bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research Note: A simple method of image solution for a sphere of constant electrical potential in a conducting half‐space: implications for the applied potential method
Authors: Butler S.L. 
Published: February 2017

ABSTRACTThe applied potential, or mise‐à‐la‐masse, method is used in mineral exploration and environmental applications to constrain the shape and extent of conductive anomalies. However, few simple calculations exist to help gain understanding and intuition regarding the pattern of measured electrical potential at the ground surface. While it makes intuitive sense that the conductor must come close to the ground surface in order for the lateral extent of the potential anomaly to be affected by the dimensions of the conductor rather than simply by the depth, no simple calculation exists to quantify this effect. In this contribution, a simple method of images solution for the case of a sphere of constant electrical potential in a conducting half‐space is presented. The solution consists of an infinite series where the first term is the same as the method of images solution for a point current source in an infinite half‐space. The higher order terms result from the interaction of the constant potential sphere with the no‐flux boundary condition representing the ground surface and cause the change in the shape of the potential anomaly that is of interest in the applied potential method. The calculation is relevant to applied potentials when the conductive anomaly is limited in all three space dimensions and is highly conductive. Using the derived formula, it is shown that, while the electrical potential at the ground surface caused by the sphere is affected even when the sphere is quite deep, the ratio of the potential to the current, a quantity that is more relevant to the applied potential method, is not affected until the centre of the sphere is within two radii of the ground surface. An expression for the contact resistance of the sphere as a function of depth is also given, and the contact resistance is shown to increase by roughly 45% as the sphere is moved from great depth to the ground surface.
Transcriptomic and virulence factors analyses of Cryptococcus neoformans hypoxia response
Authors: Kong Qingtao , Yang Rui , Wang Zhen , Zhou Wenquan , Du Xue , Huang Suyang , Jiang Yuan , Liu Weida , Sang Hong 
Published: February 2017

Cryptococcus neoformans is an environmental pathogen requiring atmospheric levels of oxygen for optimal growth. Upon inhalation, C. neoformans disseminates to the brain and causes meningoencephalitis. However, the mechanisms by which the pathogen adapts to the low‐oxygen environment in the brain have not been investigated. We isolated a C. neoformans strain with a small capsule from a host tissue, although this strain produces large capsules in normoxic conditions. We hypothesize that this difference in capsule size is attributed to hypoxia caused by chronic inflammatory response. This study investigated the effect of hypoxia on virulence factors (including capsule, melanin, urease, and phospholipase) of C. neoformans and conducted transcriptomic analyses of the virulence‐associated genes. We found that C. neoformans grew under hypoxic condition, albeit slowly, and that hypoxia may have inhibited the capsule size, melanin production, and phospholipase and urease activities in C. neoformans.
When Cooperation and Compromise Fail: Distrusting and Denigrating the Moral Character of Those Who Disagree
Authors: Hughes Jamie S. 
Published: February 2017

AbstractPeople tend to view adversaries with dissimilar opinions as irrational, biased, and negatively motivated. However, when adversaries show honest attempts to compromise evaluations should become more positive. Unfortunately, the evidence presented here does not support this idea. Across five studies using different attitudinal issues perceivers believed dissimilar attitude targets were negatively motivated, untrustworthy, and less moral compared to similar attitude targets. Further, moral character judgments mediated the relationship between attitude target and trust. Fortunately, the strong association between motives and morality provided an opportunity to intervene. Those explicitly told that an attitude target held positive rather than negative long‐term motives evaluated those with dissimilar and similar attitudes positively. Discussion focuses on the importance of these findings for theory and public policy.
Self‐management interventions in pediatric epilepsy: What is the level of evidence?
Authors: Wagner Janelle L. , Modi Avani C. , Johnson Erica K. , Shegog Ross , Escoffery Cam , Bamps Yvan , Austin Joan K. , Schultz Rebecca J. , MapelLentz Sarah , Smith Gigi 
Published: February 2017

SummaryObjectiveTo respond to recommendations put forth by the Institute of Medicine to improve self‐management resources for youth with epilepsy by conducting a systematic review of the self‐management literature in pediatric epilepsy.MethodsInclusion criteria: youth birth to 18 years with a seizure disorder or an epilepsy diagnosis and/or their caregivers, published 1985–2014 in English, and conducted in countries with a very high human development index. Abstract and keywords had to explicitly refer to “self‐care” (pre‐1996) and/or self‐management (post‐1996). The review was conducted in seven phases: (1) identification of bibliographical search criteria and databases; (2) abstract assessment; (3) full article review; (4) organization of final citations into instrument development, intervention, factors associated with self‐management categories; (5) American Academy of Neurology level of evidence (LOE) assessment for intervention studies; (6) CONsolidated Standards of Reporting Trials (CONSORT) evaluation of LOE level III articles utilizing a control group; and (7) categorization of intervention outcomes across four self‐management domains.ResultsOf the 87 articles that met eligibility criteria, 24 were interventions and received LOE scores of level III or IV. Most studies (n = 20, 80%) were scored at level III; however, only eight had a control group and adhered to CONSORT guidelines. They largely neglected information on intervention components (e.g., implementation, treatment fidelity), randomization, participant flow, missing data, and effect size or confidence intervals. The 24 intervention studies reported significant impact in four domains: individual (n = 13), family (n = 6), health care system (n = 3), and community (n = 2).SignificanceThere are no level I or II studies. No study met full CONSORT guidelines. Outcomes were well described; however, the nature of self‐management interventions (e.g., multiple foci, skills targeted) and the observed heterogeneity in outcomes complicates comparisons across studies. Randomized controlled trials (RCTs) that include large sample sizes, impact of the intervention, treatment fidelity, and power analyses are necessary to further this evidence base.
Expanding the view of Clock and cycle gene evolution in Diptera
Authors: Chahad‐Ehlers S. , Arthur L. P. , Lima A. L. A. , Gesto J. S. M. , Torres F. R. , Peixoto A. A. , de Brito R. A. 
Published: February 2017

AbstractWe expanded the view of Clock (Clk) and cycle (cyc) gene evolution in Diptera by studying the fruit fly Anastrepha fraterculus (Afra), a Brachycera. Despite the high conservation of clock genes amongst insect groups, striking structural and functional differences of some clocks have appeared throughout evolution. Clk and cyc nucleotide sequences and corresponding proteins were characterized, along with their mRNA expression data, to provide an evolutionary overview in the two major groups of Diptera: Lower Diptera and Higher Brachycera. We found that AfraCYC lacks the BMAL (Brain and muscle ARNT‐like) C‐terminus region (BCTR) domain and is constitutively expressed, suggesting that AfraCLK has the main transactivation function, which is corroborated by the presence of poly‐Q repeats and an oscillatory pattern. Our analysis suggests that the loss of BCTR in CYC is not exclusive of drosophilids, as it also occurs in other Acalyptratae flies such as tephritids and drosophilids, however, but it is also present in some Calyptratae, such as Muscidae, Calliphoridae and Sarcophagidae. This indicates that BCTR is missing from CYC of all higher‐level Brachycera and that it was lost during the evolution of Lower Brachycera. Thus, we can infer that CLK protein may play the main role in the CLK\CYC transcription complex in these flies, like in its Drosophila orthologues.
Land Market Restrictions, Women's Labour Force Participation and Wages in a Rural Economy
Authors: Emran M. Shahe , Shilpi Forhad 
Published: February 2017

AbstractWe analyse the effects of land market restrictions on the rural labour market outcomes for women. The existing literature emphasizes two mechanisms through which land restrictions can affect economic outcomes: collateral value of land, and (in)security of property rights. Our analysis focuses on an alternative mechanism where land restrictions increase costs of migration out of villages. Testable prediction of collateral channel is that wages remain unchanged, but the effects on labour force participation are ambiguous. Insecurity of property rights in land reduces labour force participation, but leaves wages undisturbed. In contrast, if land restrictions work primarily through higher migration costs, labour force participation increases, while wages decline. For identification, we exploit a natural experiment in Sri Lanka where historical malaria played a unique role in land policy. We provide robust evidence of a positive effect of land restrictions on women's labour force participation, but a negative effect on female wages. The empirical results thus contradict a collateral or insecure property rights effect, but supports migration costs as the primary mechanism.
Knowledge and attitudes of women regarding gynaecological cancer prevention in an urban area of Greece in financial crisis
Authors: Saridi Maria , Kapogeorgou Eleni , Rekleiti Maria , Geitona Maria , Souliotis Kyriakos 
Published: February 2017

IntroductionPreventive gynaecological examinations (PGEs) are the main means of monitoring gynaecological cancers across the developed world. The purpose of this study was to investigate the perceptions and attitudes of women of a regional municipality of Greece, regarding preventive gynaecological examinations amid economic crisis.Material and methodsThe study included 360 women aged 20–70 years, who lived in an urban area of Greece. A specialised, valid and anonymous questionnaire that included questions about perceptions and attitudes regarding preventive gynaecological examinations was used. The data analysis was performed using the statistical package spss 21.ResultsIt was found that women who lived in less developed areas had had lower educational levels and higher abstinence rates from medical examinations. The main source of information about sexually transmitted diseases was their social circle (48%), but the gynaecologist is the one preferred (54.8) to inform about preventive gynaecological examinations. Thirty per cent of the participants had never have a mammogram, while 33.9% of the sample did not show the same result, although considered the Pap test necessary. The main cause of women's abstention of preventive gynaecological examinations is the financial crisis.ConclusionsThe current financial crisis has negatively affected the women's ability to afford gynaecological examinations. Therefore, it is necessary to inform the population about the necessity of preventive gynaecological examinations starting from school age and at the same time, health information and promotion campaigns should be launched at a national level.
Draft Genome Sequence of Bifidobacterium lemurum DSM 28807
T
Isolated from the Gastrointestinal Tracts of Ring-Tailed Lemurs (
Lemur catta
)
Authors: Toh Hidehiro , Matsubara Takehiro , Tomida Shuta , Mimura Iyo , Arakawa Kensuke , Kikusui Takefumi , Morita Hidetoshi 
Published: February 2017

ABSTRACT

Bifidobacterium lemurum
DSM 28807
T
was isolated from the gastrointestinal tracts of ring-tailed lemurs (
Lemur catta
). Here, we report the first draft genome sequence of this organism.
Isostasy as a tool to validate interpretations of regional geophysical datasets – application to the mid-Norwegian continental margin
Authors: Gradmann Sofie , Haase Claudia , Ebbing Jörg 
Published: February 2017

Abstract
Isostasy is a well understood concept, yet rarely applied to its full capacity in regional interpretations of crustal structures. In this study, we utilize a recent density model for the entire NE Atlantic, based on refraction seismic data and gravity inversion, to calculate isostatically balanced bathymetry along the mid-Norwegian margin. Since gravity and isostatically balanced elevation are independent observables but both depend on the underlying density model, consistencies and discrepancies point towards model deficits, erroneously interpreted or poorly understood areas.
Four areas of large isostatic residuals are identified. Along the outer Vøring Margin, a mass deficit points to more extensive high-density bodies or a shallower Moho than currently mapped. Farther seaward, along the Vøring Marginal High, a mass excess indicates inaccurate mapping of the continent–ocean boundary and surrounding structures. A number of eclogitic bodies along the proximal mid-Norwegian margin have been described in recent publications and their presence is now also confirmed by isostatic calculations. Major elevation and gravity residuals along the transition between the Vøring and Møre margins signify that the structure of this region is poorly understood and modifications to the mapped continent–ocean transition may be required.
The Fourth Way
Authors: Blake Anthony 
Published: February 2017

This essay describes the ideas, practices, and purposes of the “Fourth Way,” introduced by G. I. Gurdjieff a hundred years ago. It does so, through the eyes of the author, via a narrative largely based on his experiences with one of Gurdjieff’s leading exponents named John Bennett. The author expresses his own unfolding understanding of the Fourth Way rather than attempting to sum up or define it. The many illustrations included give a more concrete flavor than words alone can provide. This article covers the decade 1960–1970, and is the first part of a longer autobiographical work that will resume the story from 1970 until the present day.
Physical activity, sedentary behaviour and sleep in COPD guidelines: A systematic review
Authors: Lewthwaite Hayley , Effing Tanja W , Olds Timothy , Williams Marie T 
Published: February 2017

Objectives: Physical activity, sedentary and sleep behaviours have strong associations with health. This systematic review aimed to identify how clinical practice guidelines (CPGs) for the management of chronic obstructive pulmonary disease (COPD) report specific recommendations and strategies for these movement behaviours. Methods: A systematic search of databases (Medline, Scopus, CiNAHL, EMbase, Clinical Guideline), reference lists and websites identified current versions of CPGs published since 2005. Specific recommendations and strategies concerning physical activity, sedentary behaviour and sleep were extracted verbatim. The proportions of CPGs providing specific recommendations and strategies were reported. Results: From 2370 citations identified, 35 CPGs were eligible for inclusion. Of these, 21 (60%) provided specific recommendations for physical activity, while none provided specific recommendations for sedentary behaviour or sleep. The most commonly suggested strategies to improve movement behaviours were encouragement from a healthcare provider (physical activity n = 20; sedentary behaviour n = 2) and referral for a diagnostic sleep study (sleep n = 4). Conclusion: Since optimal physical activity, sedentary behaviour and sleep durations and patterns are likely to be associated with mitigating the effects of COPD, as well as with general health and well-being, there is a need for further COPD-specific research, consensus and incorporation of recommendations and strategies into CPGs.
Polloneite, a new complex Pb(-Ag)-As-Sb sulfosalt from the Pollone mine, Apuan Alps, Tuscany, Italy
Authors: Topa Dan , Keutsch Frank N. , Makovicky Emil , Kolitsch Uwe , Paar Werner 
Published: February 2017

AbstractPolloneite, ideally AgPb46As26Sb23S120, is a new N = 4 member of the sartorite homologous series. It occurs in a matrix of baryte from the Pizzone level of the Pollone baryte-pyrite-(Pb-Zn-Ag) deposit at Valdicastello Carducci, near Pietrasanta, in the Apuan Alps, Tuscany, Italy, as anhedral grains up to 0.5 mm across. The mineral is opaque, greyish black with a metallic lustre. In reflected light polloneite is white, bireflectance is moderate. Internal reflections are absent. Under crossed polars, anisotropism is moderate with rotation tints in brown-violet and deep grey. The reflectance data (%, air) are: 30.2, 42.4 at 470 nm, 28.8, 41.0 at 546 nm, 27.9, 39.8 at 589 nm and 26.0, 37.4 at 650 nm. Mohs hardness is 3–3½, microhardness VHN50exhibits a mean value of 200 kg mm-2. The average results of 15 electronmicroprobe analyses of three grains are Ag 0.71(5), Pb 52.05(21), As 10.61(22), Sb 15.40(12), S 21.16(8), total 99.92(15) wt.%, corresponding to Ag1.20Pb45.76As25.79Sb23.04S120.21(on the basis of Me + S = 216 apfu). The simplified formula AgPb46As26Sb23S120is in accordance with the results of a crystal structure determination. The calculated density is 5.77 g cm–3. Polloneite is monoclinic, space group P21, a = 8.413(2), b = 25.901(5), c = 23.818(5) Å, β = 90.01(3)°, V = 5189.8(18)Å3, Z = 1. The strongest eight lines in the calculated powder-diffraction pattern [d in Å(I)hkl] are 3.795(100)(026), 3.414(60)(233), 3.238(69)(080), 3.020(97)(253), 2.922(82)(066), 2.738(73)(236), 2.375(79)(290) and 2.103(64)(400). Polloneite is a new N = 4 member of the sartorite homologous series with substantial Sb and small, but important, Ag content. It is a three-fold superstructure with a tripled unit-cell parameter, 7.9 Å, of sartorite homologues. In the As-Sb rich slabs, several types of crankshaft chains and isolated (As,Sb)–S polyhedra occur. A sequence of three different, tightly bonded double-layer fragments (broad ribbons) contains two asymmetric fragments with long crankshaft chains whereas the third fragment type, with Ag, contains small mirror-symmetrical metalloid groups and no crankshaft chains. This configuration can potentially cause order-disorder phenomena in the structure. The threefold superstructure and the mixed As-Sb character distinguish polloneite from veenite and from dufrénoysite, respectively.
Design and results of phase I cancer clinical trials: three-year experience at M.D. Anderson Cancer Center.
Authors: Smith T L , Lee J J , Kantarjian H M , Legha S S , Raber M N 
Published: February 2017

PURPOSE Alternatives to the standard design for conducting phase I trials are proposed with increasing frequency. This study was undertaken to determine how phase I trials are currently conducted and to provide a basis for evaluation of evolving methodology. SUBJECTS AND METHODS All published phase I trials from a single institution over a 3-year period were reviewed to determine the method of selection of the recommended dose for a phase II trial of a new agent, type and extent of toxicity, number of patients treated at the recommended dose, and clinical response. RESULTS All 23 published trials used the standard method of entering cohorts of patients at increasing dose levels and observing toxic effects to determine the dose recommended for phase II study. Among 610 patients, 26% were treated at or within 10% of the recommended dose and 35% were treated with less than 50% of the recommended dose or on a trial that yielded no recommended dose. Among 18 trials using agents previously tested in humans, fewer patients were treated at much less than the recommended dose. For trials in which myelosuppression was dose-limiting, the estimated probability of serious myelosuppression associated with the recommended dose ranged from 23% to 66%. Nineteen patients (3%) responded to therapy. CONCLUSION This summary of phase I trials recently conducted at M.D. Anderson Cancer Center confirms the need for alternative methods, provides baseline information against which alternatively conducted trials can be compared, and demonstrates some practical clinical trial issues not generally considered when alternative methods are proposed.
Clinical experience with oral methadone administration in the treatment of pain in 196 advanced cancer patients.
Authors: De Conno F , Groff L , Brunelli C , Zecca E , Ventafridda V , Ripamonti C 
Published: February 2017

PURPOSE The aims of this study were to describe the analgesia, side effects, and dosage and the causes of suspension of treatment in a large sample of advanced cancer patients with pain after treatment with oral methadone from 7 to 90 days. PATIENTS AND METHODS In a retrospective study, data collected for 196 advanced cancer outpatients with moderate to severe pain treated at 8-hour intervals with oral methadone in solution form from February 1993 to February 1995 were analyzed at baseline (time 0) and then at 7, 15, 30, 45, 60, and 90 days. The following parameters were assessed: Karnofsky Performance Status, intensity of pain (using the Integrated Pain Score [IPS], intensity of pain, insomnia, drowsiness, confusion, dry mouth, nausea, vomiting, constipation, and dyspnea (using the Therapy Impact Questionnaire [TIQ], mean daily dose of drug administered, and reasons for withdrawal from study. The period when pain was reduced by > or = 35% with respect to baseline was evaluated with the Palliation Index. The association of the degree of palliation of pain with the age of the patients, tumor site, analgesic treatment taken at baseline, and daily mean dose of methadone administered during the follow-up period was analyzed by means of the Kruskal-Wallis test. RESULTS A reduction in pain intensity with respect to baseline occurred at each analysis time, and in 55.1% of the patients the reduction during the follow-up period was > or = 35% according to the Palliation Index. The mean dose of oral methadone ranged from 14 mg at day 7 to 23.65 mg at day 90. There was an overall worsening of the other symptoms, but a high percentage of the patients reported an amelioration of insomnia with respect to baseline. There was a statistically significant association (P < .0001) between the Palliation Index and the analgesic therapy administered at baseline. Only 11.2% of the patients withdrew from the study due to analgesic inefficacy and 6.6% due to methadone-related side effects (10 patients with drowsiness and three with severe constipation. CONCLUSION Oral methadone administered every 8 hours was shown to be an appropriate analgesic therapy in the treatment of advanced cancer-related pain. The worsening of the other symptoms under study can be considered linked to the progression of the disease, and in fact, only a small percentage of the patients reported methadone-related side effects that warranted suspension of treatment. We consider oral methadone to be a useful analgesic therapy, and it should be considered in clinical practice for the treatment of cancer pain.