bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance
Authors: Chen Ping , Lee Nathan V. , Hu Wenyue , Xu Meirong , Ferre Rose Ann , Lam Hieu , Bergqvist Simon , Solowiej James , Diehl Wade , He You-Ai , Yu Xiu , Nagata Asako , VanArsdale Todd , Murray Brion W. 
Published: August 2016

Abstract
Therapeutically targeting aberrant intracellular kinase signaling is attractive from a biological perspective but drug development is often hindered by toxicities and inadequate efficacy. Predicting drug behaviors using cellular and animal models is confounded by redundant kinase activities, a lack of unique substrates, and cell-specific signaling networks. Cyclin-dependent kinase (CDK) drugs exemplify this phenomenon because they are reported to target common processes yet have distinct clinical activities. Tumor cell studies of ATP-competitive CDK drugs (dinaciclib, AG-024322, abemaciclib, palbociclib, ribociclib) indicate similar pharmacology while analyses in untransformed cells illuminates significant differences. To resolve this apparent disconnect, drug behaviors are described at the molecular level. Nonkinase binding studies and kinome interaction analysis (recombinant and endogenous kinases) reveal that proteins outside of the CDK family appear to have little role in dinaciclib/palbociclib/ribociclib pharmacology, may contribute for abemaciclib, and confounds AG-024322 analysis. CDK2 and CDK6 cocrystal structures with the drugs identify the molecular interactions responsible for potency and kinase selectivity. Efficient drug binding to the unique hinge architecture of CDKs enables selectivity toward most of the human kinome. Selectivity between CDK family members is achieved through interactions with nonconserved elements of the ATP-binding pocket. Integrating clinical drug exposures into the analysis predicts that both palbociclib and ribociclib are CDK4/6 inhibitors, abemaciclib inhibits CDK4/6/9, and dinaciclib is a broad-spectrum CDK inhibitor (CDK2/3/4/6/9). Understanding the molecular components of potency and selectivity also facilitates rational design of future generations of kinase-directed drugs. Mol Cancer Ther; 15(10); 2273–81. ©2016 AACR.
Echocardiographic Predictors of Sudden Cardiac Death
Authors: Konety Suma H. , Koene Ryan J. , Norby Faye L. , Wilsdon Tony , Alonso Alvaro , Siscovick David , Sotoodehnia Nona , Gottdiener John , Fox Ervin R. , Chen Lin Y. , Adabag Selcuk , Folsom Aaron R. 
Published: August 2016

Background—
This study assessed the echocardiographic predictors of sudden cardiac death (SCD) within 2 population-based cohorts.

Methods and Results—
Echocardiograms were obtained on 2383 participants (1993–1995) from the ARIC study (Atherosclerosis Risk in Communities; 100% black) and 5366 participants (1987–1989 and 1994–1995) from the CHS (Cardiovascular Health Study). The main outcome was physician-adjudicated SCD. We used Cox proportional-hazards models with incident coronary heart disease and heart failure as time-dependent covariates to assess the association between echocardiographic variables and SCD, adjusting for Framingham risk score variables, coronary heart disease, and renal function. Cohort-specific results were meta-analyzed. During a median follow-up of 7.3 and 13.1 years, 44 ARIC study participants and 275 CHS participants had SCD, respectively. In the meta-analyzed results, the adjusted hazard ratios (95% confidence intervals) for predictors of SCD were 3.07 (2.29–4.11) for reduced left ventricular ejection fraction; 1.85 (1.36–2.52) for mitral annular calcification; 1.64 (1.07–2.51) for mitral E/A >1.5, and 1.52 (1.14–2.02) for mitral E/A <0.7 (versus mitral E/A 0.7–1.5); 1.30 (1.15–1.48) per 1 SD increase in left ventricular mass; and 1.15 (1.02–1.30) per 1 SD increase in left atrial diameter. A receiver-operating characteristic model for prediction of SCD using Framingham risk score variables had a C statistic of 0.61 for ARIC study and 0.67 for CHS; the full multivariable model including all echocardiographic variables had a C statistic of 0.76 for ARIC study and 0.74 for CHS.

Conclusions—
In addition to reduced left ventricular ejection fraction, we identified other echocardiographic-derived variables predictive for SCD that provided incremental value compared with clinical risk factors.
Long-Term Outcomes of the Ross Procedure Versus Mechanical Aortic Valve Replacement
Authors: Mazine Amine , David Tirone E. , Rao Vivek , Hickey Edward J. , Christie Shakira , Manlhiot Cedric , Ouzounian Maral 
Published: August 2016

Background:
The ideal aortic valve substitute in young and middle-aged adults remains unknown. We sought to compare the long-term outcomes of patients undergoing the Ross procedure and those receiving a mechanical aortic valve replacement (AVR).

Methods:
From 1990 to 2014, 258 patients underwent a Ross procedure and 1444 had a mechanical AVR at a single institution. Patients were matched into 208 pairs through the use of a propensity score. Mean age was 37.2±10.2 years, and 63% were male. Mean follow-up was 14.2±6.5 years.

Results:

Overall survival was equivalent (Ross versus AVR: hazard ratio, 0.91, 95% confidence interval, 0.38–2.16;
P
=0.83), although freedom from cardiac- and valve-related mortality was improved in the Ross group (Ross versus AVR: hazard ratio, 0.22; 95% confidence interval, 0.034–0.86;
P
=0.03). Freedom from reintervention was equivalent after both procedures (Ross versus AVR: hazard ratio, 1.86; 95% confidence interval, 0.76–4.94;
P
=0.18). Long-term freedom from stroke or major bleeding was superior after the Ross procedure (Ross versus AVR: hazard ratio, 0.09; 95% confidence interval, 0.02–0.31;
P
<0.001).

Conclusions:
Long-term survival and freedom from reintervention were comparable between the Ross procedure and mechanical AVR. However, the Ross procedure was associated with improved freedom from cardiac- and valve-related mortality and a significant reduction in the incidence of stroke and major bleeding. In specialized centers, the Ross procedure represents an excellent option and should be considered for young and middle-aged adults undergoing AVR.
Nations in the bubble of social reality: language and all that
Authors: Kamusella Tomasz 
Published: August 2016

Nations in the bubble of social reality: language and all that In the last century and a half scholars from different disciplines began to distinguish between material reality (the universe), the biosphere, and social reality (the semiosphere), as three important heuristic categories. In the latter half of the 20th century, the philosophers John L. Austin and John Searle proposed that language and its use enable humans to generate social reality. They also analyzed the mechanisms of the process. From another perspective, the evolutionary anthropologist Robin Dunbar offered an explanation of how language was selected in the process of human evolution, and argued that its primary function is group-building, that is, the generation of social cohesion. Drawing on these insights, the article proposes that the dilemma of whether nations exist objectively or are subjective entities can be resolved by analyzing this problem in the light of Searle’s distinction between ontological objectivity / subjectivity and epistemic objectivity / subjectivity. Narody w koronie rzeczywistości społecznej widziane z perspektywy językaOd półtora stulecia badacze z zakresu różnych dyscyplin zaczęli wyraźnie rozróżniać pomiędzy rzeczywistością materialną (tj. wszechświatem, ogółem bytów materialnych), biosferą oraz rzeczywistością społeczną (semiosferą), jako powiązanymi ze sobą trzema kategoriami analizy heurystycznej. W drugiej połowie XX stulecia filozofowie języka John L. Austin i John Searle dali tezę, iż to język oraz jego użycie pozwala ludziom generować rzeczywistość społeczną. Obydwaj również badali mechanizmy rządzące tym procesem generacji. Z kolei psycholog ewolucyjny Robin Dunbar przedstawił model wyjaśniający, jak język (tzn. biologiczna zdolność językowa) został wyselekcjonowany w procesie ewolucji. Na tej podstawie postawił on tezę, iż prymarną funkcją języka jest umożliwianie budowania grup ludzkich, czyli innymi słowy, generowanie potrzebnej ku temu spójności społecznej. Korzystając z powyżej wymienionych ustaleń, artykuł proponuje nowe podejście do szeroko dyskutowanej kwestii czy narody istnieją obiektywnie lub są subiektywnymi bytami, analizując to zagadnienie w świetle zaproponowanego przez J. Searle’a rozróżnienia pomiędzy ontyczną obiektywnością/subiektywnością a epistemiczną obiektywnością/subiektywnością.
The Princip cult and what it evokes in Hungary
Authors: Weaver Eric Beckett 
Published: August 2016

The Princip cult and what it evokes in HungaryOn the 28th of June, 1914, a consumptive student, Gavrilo Princip, shot and killed prince Franz Ferdinand, the heir to the throne of the Austro-Hungarian Monarchy. The prince’s wife Sofia was also killed by a stray bullet. In the century that has passed since the assassination, the memory of Princip and the cult constructed around him has been distorted beyond recognition. As local and international politics were altered, so changed Princip’s image. The memory of Princip now evokes strong reactions not only in the South Slav lands, but in Hungary as well. In what follows, we will examine possible sources for the strong reactions evoked by Princip’s memory among Hungarians a century after his act. Kult Principa i co on ewokuje na WęgrzechW dniu 28 czerwca 1914 roku chory na gruźlicę student Gavrilo Princip zastrzelił księcia Franciszka Ferdynanda, następcę tronu monarchii austro-węgierskiej. Od zbłąkanej kuli zginęła także żona księcia, Zofia. W okresie stulecia, które minęło od tego zabójstwa, pamięć o Principie i kult zbudowany wokół niego przeobraziły się diametralnie. Wraz z przemianami polityki lokalnej i międzynarodowej zmieniało się także postrzeganie Principa. Obecnie pamięć o Principie wywołuje silne reakcje nie tylko na ziemiach południowosłowiańskich, ale również na Węgrzech. Autor artykułu docieka, skąd mogą wypływać silne reakcje, jakie pamięć Principa wywołuje u Węgrów sto lat po jego czynie.
No Austrians in South Tyrol? Why the German-speaking community in Italy’s South Tyrol (Alto Adige) province is not usually called an Austrian minority
Authors: Volkmer Michael Julian Emanuel 
Published: August 2016

No Austrians in South Tyrol? Why the German-speaking community in Italy’s South Tyrol (Alto Adige) province is not usually called an Austrian minorityThe article discusses the question why the German-speakers in Northern Italy’s South Tyrol province are only very rarely referred to as an Austrian minority, in spite of the fact that they were split off from Austria, and not Germany, in the aftermath of World War I. An analysis of the naming of German-speaking South Tyroleans in German, Austrian, Italian and English-speaking news media, which demonstrates a preference for terms such as “German-speaking minority” or “German minority” over “Austrian minority and equivalents, is followed by a discussion of three hypotheses to account for the situation. The author shows how the question of how to name the German-speaking South Tyroleans is closely intertwined with the issue of Austrian national identity and its re-orientation away from Germany in the aftermath of the Second World War. The author comes to the conclusion that the minority is not usually referred to as Austrian both due to the fact that it is difficult to include them in the young (civic) Austrian nation in a logically consistent manner, and due to the German-speaking South Tyroleans’ own inconsistent self-identification as Austrians. Nie ma Austriaków w Tyrolu Południowym? Dlaczego niemieckojęzyczna wspólnota we włoskiej prowincji Tyrol Południowy (Alto Adige) zwykle nie jest nazywana mniejszością austriackąArtykuł podejmuje kwestię, dlaczego niemieckojęzyczna ludność północnowłoskiej prowincji Tyrol Południowy rzadko bywa nazywana mniejszością austriacką, pomimo tego że w efekcie I wojny światowej odłączona została ona od Austrii, a nie od Niemiec. Analiza nazewnictwa odnoszonego do niemieckojęzycznej ludności Tyrolu Południowego, które występuje w informacyjnych środkach przekazu: niemiecko-, austriacko-, włosko- i anglojęzycznych pozwala stwierdzić, że preferowane są określenia takie jak „mniejszość niemieckojęzyczna” lub „mniejszość niemiecka”, zamiast „mniejszość austriacka” i terminy ekwiwalentne. Następnie omówione został trzy hipotezy mogące wyjaśnić tę sytuację. Autor ukazuje, jak ściśle współzależą od siebie kwestia nazewnictwa niemieckojęzycznej ludności Tyrolu Południowego i kwestia austriackiej tożsamości narodowej oraz jej odchodzenia od Niemiec w następstwie II wojny światowej. Autor dochodzi do wniosku, że omawiana tu mniejszość zwykle nie jest uznawana za austriacką zarówno z tego powodu, iż trudno jest umiejscowić ją w młodym (obywatelskim) narodzie austriackim w sposób logicznie konsekwentny, jak i z racji własnej niekonsekwentnej samoidentyfikacji niemieckojęzycznych Tyrolczyków Południowych jako Austriacy.
Między patriotyzmem i nacjonalizmem na tle popnacjonalizmu w muzyce rockowej
Authors: Mazurkiewicz Michał Maurycy 
Published: August 2016

Between patriotism and nationalism: pop-nationalism in rock musicThis article addresses issues which can be seen in the manifestation of ethno-nationalism in rock music. Concepts of nationalism and patriotism are illustrated by references to the literature on the subject. Polish national ideology is formed, for example, on a pragmatic concept of nationalism. A new direction in this work is an examination of pop-nationalism of rock music on the example of the Polish band “Horytnica”. Między patriotyzmem i nacjonalizmem na tle popnacjonalizmu w muzyce rockowejW artykule zajmuję się problematyką popnacjonalizmu przejawiającą się w muzyce rockowej. Ze względu na złożoność pojęć nacjonalizmu i patriotyzmu przytaczam interesujące nas tu opinie na ten temat w literaturze przedmiotu. Pojęcie nacjonalizmu ustalam pragmatycznie na przykładzie deklaracji ideowych polskich organizacji narodowych. Novum w niniejszej pracy stanowi problem popnacjonalizmu w muzyce rockowej, przedstawiony na przykładzie twórczości zespołu „Horytnica”, odwołującej się do wspomnianych idei.
Wielokulturowość: lekcje przeszłości
Authors: Surman Jan 
Published: August 2016

Multiculturalism: lessons from the pastReview: Understanding Multiculturalism. The Habsburg Central European Experience, ed. Johannes Feichtinger, Gary B. Cohen, Berghahn, Oxford–New York, 2014 (Austrian and Habsburg Studies 17), pp. 246While recently the concept of multiculturalism has been an object of strong criticism from the political side, the book under review takes another turn scrutinizing and historicizing it. Looking at Central Europe through the lenses of nonessentialism, postcolonialism or national indifference, multiple authors propose not only new ways of reading the history of the region, but also of establishing categories for the future research in historical cultural studies. Wielokulturowość: lekcje przeszłościRecenzja: Understanding Multiculturalism. The Habsburg Central European Experience, red. Johannes Feichtinger, Gary B. Cohen, Berghahn, Oxford–New York, 2014 (Austrian and Habsburg Studies 17), ss. 246.Podczas gdy koncept wielokulturowości był w ostatnim czasie obiektem mocnej krytyki, szczególnie ze strony polityki, recenzowana książka obiera inną pozycję, analizując i historyzując go. Spoglądając na Europe Środkową z użyciem nieesecjalizujących czy postkolonialnych koncepcji, autorzy proponują nie tylko nowe sposoby odczytania historii regionu, lecz także nowe kategorie dla przyszłych badań historii kulturowej.
Association of serum chemerin concentrations with the presence of atrial fibrillation
Authors: Zhang Guowei , Xiao Mochao , Zhang Lili , Zhao Yue , Yang Qinghui 
Published: August 2016

Objective Chemerin, a newly discovered adipokine, is correlated with hypertension, diabetes and coronary heart disease. The aim of this study is to investigate the association of serum chemerin concentrations with the presence of atrial fibrillation. Methods Serum chemerin concentrations were determined in 256 patients with atrial fibrillation and 146 healthy subjects. Atrial fibrillation patients were then divided into paroxysmal, persistent and permanent atrial fibrillation. Results Serum chemerin concentrations were significantly higher in atrial fibrillation patients compared with healthy controls. In subgroup studies, patients with permanent atrial fibrillation had higher serum chemerin concentrations than those with persistent and paroxysmal atrial fibrillation. Furthermore, significant higher serum chemerin concentrations were observed in persistent atrial fibrillation patients compared with paroxysmal atrial fibrillation subjects. Serum chemerin concentrations were associated with the presence of atrial fibrillation after logistic regression analysis. Pearson correlation analysis revealed a positive relation of serum chemerin concentrations with body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, low-density lipoprotein cholesterol, blood urea nitrogen, creatinine, C-reactive protein and left atrial diameter. Conclusion Serum chemerin concentrations are associated with the presence of atrial fibrillation and atrial remodelling.
Effects of time and temperature on 48 routine chemistry, haematology and coagulation analytes in whole blood samples
Authors: van Balveren Jasmijn A , Huijskens Mirelle JAJ , Gemen Eugenie FA , Péquériaux Nathalie CV , Kusters Ron 
Published: August 2016

Background Phlebotomy for the purpose of blood analysis is often performed at remote locations, and samples are usually temporarily stored before transport to a central laboratory for analysis. The circumstances during storage and shipment may not meet the necessary requirements. If analysed anyway, false results may be generated. We therefore examined the influence of precentrifugation time and temperature of the most frequently requested tests in whole blood. Methods Healthy volunteers donated blood in which 48 analytes were tested. Routine chemistry was performed in lithium heparin tubes, haematology in ethylenediaminetetraacetic acid tubes, coagulation in citrate tubes and glucose in sodium fluoride tubes. One tube was measured directly. The others were kept at different temperatures (4, 8, 20 or 30℃) and stored for 4, 6, 8 or 24 h before analysis. Additionally, some analytes were examined at 12, 16, 24 and 28℃. The mean percentage deviation was compared with different decision levels, including the total allowable error. Results When using the total allowable error as an acceptable limit, most of the investigated analytes remained stable. However, bicarbonate is unstable at almost all tested time-points and temperatures. Calcium, lactate dehydrogenase, potassium and sodium are particularly affected at low temperatures, while phosphate is mainly affected at and above room temperature after 8 h. Conclusion We established the influence of time and temperature on a broad range of analytes, which may be applied to set the limits in transportation and storage of whole blood samples.
Reforming the nations: a global study of the Need for Future Managerial Reforms in public administration
Authors: Vigoda-Gadot Eran , Cohen Noam , Tsfati Yariv 
Published: August 2016

This study deals with the Need for Future Managerial Reforms (NFMR) in public administration as perceived by university professors from around the globe. We explore and validate a new NFMR scale based on traditional principles of the New Public Management (NPM) doctrine (e.g. downsizing government, debureaucratization, decentralization, managerialism, and privatization). We also propose a global professional selection (GPS) approach to the study of need for future managerial reforms, validating it with a theoretical model, eight propositions, and four hypotheses. According to the model, managerial quality, satisfaction with public services, trust in public services and NFMR are mutually related but should be considered within the cultural dimensions of each nation. Using data from a sample of 2995 faculty members in 191 major universities from 45 nations, we demonstrate the validity of the NFMR scale and of several direct and indirect hypotheses based on the theoretical model, as well as the advantage of the GPS-controlled mediating model over a simple mediating model. The findings are discussed theoretically and practically, with their implications for the study of future NPM-style reforms and the recent trends in modern governance. Points for practitioners This study suggests that greater calls for managerial reforms, especially from the knowledgeable community, are valuable inputs that should be heard and echoed in government halls. Improving managerial quality may reduce calls for managerial reforms. Public managers should invest in increasing citizens’ satisfaction and trust as they reduce pressures on policy makers to initiate expensive reforms. Cross-country transitions of lessons and knowledge about managerial reforms should be carried out with caution as values and traditions affect the type of required reforms and their meaning for the public.
Improving patient-centered communication while using an electronic health record
Authors: Fogarty Colleen T , Winters Paul , Farah Subrina 
Published: August 2016

Introduction Researchers and clinicians are concerned about the impact of electronic health record use and patient-centered communication. Training about patient-centered clinical communication skills with the electronic health record may help clinicians adapt and remain patient-centered. Methods We developed an interactive workshop eliciting challenges and opportunities of working with the electronic health record in clinical practice, introduction of specific patient-centered behaviors and mindful practice techniques, and video demonstrating contrasts in common behavior and “better practices.” One hundred thirty-nine resident physicians and faculty supervisors in five residency training programs at the University of Rochester Medical Center participated in the workshops. Participants were asked to complete an 11-item survey of behaviors related to their use of the electronic health record prior to training and after attending training. We used paired t-tests to assess changes in self-reported behavior from pre-intervention to post-intervention. Results We trained 139 clinicians in the workshops; 110 participants completed the baseline assessment and 39 completed both the baseline and post-intervention assessment. Data from post-curriculum respondents found a statistically significant increase in “I told the patient when turning my attention from the patient to the computer,” from 60% of the time prior to the training to 70% of the time after. Discussion Data from our program evaluation demonstrated improvement in one communication behavior. Sample size limited the detection of other changes; further research should investigate effective training techniques for patient-centered communication while using the electronic health record.