Abstract P2-13-03: Complications following total skin-sparing mastectomy and expander-implant reconstruction: Effects of radiation therapy on the stages of reconstruction
Authors: Sears M , Warren Peled A , Wang F , Foster RD , Alvarado M , Wong J , Ewing CA , Esserman LJ , Sbitany H , Fowble B 
Published: May 2016

Abstract
BACKGROUND
With increasing numbers of patients requiring post-mastectomy radiation therapy (PMRT), many patients undergoing total-skin sparing mastectomy (TSSM) and immediate two-staged expander-implant (TE-I) reconstruction will receive radiation therapy (XRT) during the course of their reconstruction. Additionally, many patients undergoing TSSM for recurrent cancer have a history of prior lumpectomy and XRT. While the increased risk of reconstructive complications in the setting of XRT has been well-documented, few studies have looked at the impact of XRT on the stages of TE-I reconstruction.
METHODS
All patients undergoing TSSM and immediate two-staged TE-I reconstruction between 2006 and 2013 were identified from a prospectively maintained database. The incidences of TE-I loss and severe infection requiring admission for IV antibiotics were assessed in the subsets of patients with a prior history of XRT and those who received PMRT. Complications were divided into those following the first stage of reconstruction (TSSM and TE placement) and those following the second stage (TE-I exchange).
RESULTS
A total of 218 TSSM and TE-I reconstruction cases were included in the analysis, 85 (39%) with prior XRT and 133 (61%) with PMRT, all of whom who received PMRT prior to TE-I exchange. Mean follow-up time was 2.5 years. Nearly all cases of prior XRT occurred in patients who developed a local recurrence and then underwent TSSM; mean time from prior XRT to TSSM was 7 years (range: 2 months to 22 years). Patients with prior XRT were much more likely to develop complications following the first stage of reconstruction than after the second stage (TE-I loss: 15% vs. 4%, p = 0.02; infection: 20% vs. 8%, p = 0.02). Patients who received PMRT had low rates of complications following the first stage of reconstruction, when they had not yet received any radiation exposure (TE-I loss: 3%; infection: 8%). However, rates increased significantly following TE-I exchange, with an 18% TE-I loss and 30% rate of infection, which was nearly 4-fold higher than patients with a prior history of XRT.
CONCLUSIONS
Patients with prior XRT are at significantly increased risk of reconstructive complications following the first stage of TE-I reconstruction after TSSM, even with a remote history of XRT. However, if these patients are able to successfully maintain their reconstruction through tissue expansion, their risk of complications at the second stage is comparable to patients without radiation exposure and significantly lower than patients receiving PMRT. Careful patient selection and appropriate pre-operative counseling for TSSM and TE-I reconstruction is critical to optimize outcomes and set appropriate expectations.
Citation Format: Sears M, Warren Peled A, Wang F, Foster RD, Alvarado M, Wong J, Ewing CA, Esserman LJ, Sbitany H, Fowble B. Complications following total skin-sparing mastectomy and expander-implant reconstruction: Effects of radiation therapy on the stages of reconstruction. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P2-13-03.