bluuebunny/crossref_metadata_2025_split huggingface dataset:
A real-world observational study to evaluate the safety & effectiveness of Naftifine 2% cream in patients with superficial fungal skin infection
Authors: Chinda Monika , Godse Kiran , Vidya T S , Adhikari Pankaj , Prasad AK , Raj Chinmoy , Bhaskar Gaurav , Mapare Arjun , Jaiswal Ashok D 
Published: September 2024

Naftifine hydrochloride, an allylamine, is a topical agent used in treating superficial fungal infections, especially dermatophytosis. The objective of this study was to assess the safety and effectiveness of naftifine 2% cream in Indian patients with superficial fungal skin infection. A real-world observational study to evaluate the safety & effectiveness of Naftifine 2% cream in patients with superficial fungal skin infection.It was an open-label, multi-centric, observational, prospective real-world study conducted on Indian patients, where subjects were advised to apply naftifine 2% cream on the affected area at the discretion of the treating physician. Effectiveness was determined by assessing the clinical cure (absence of signs and symptoms) and/or mycological cure (negative microscopic KOH test) at the end of the treatment. Safety & tolerability were evaluated based on the presence of adverse events and their severity. The patient compliance was recorded based on the investigator's assessment.A total of 463 patients were enrolled in the study, out of which 82.07% achieved a clinical cure at the end of the treatment. The skin scraping for microscopic KOH mounting was available for 94 patients out of which the mycological cure was observed in 89 patients (94.6%) (p&#60;0.0001) at the end of the treatment. Our study recorded a lower incidence of adverse events (2.4%), commonly including dermatitis, pruritis, skin irritation at the application site, and erythema. The reported adverse events were mild or moderate and were cured within 2-7 days. The naftifine 2% cream was well tolerated by 70.8% of the patients. Upon completion of the treatment, 296 patients (64.1%) exhibited 100% compliance to the study drug.Topical Naftifine 2% cream was safe and effective in Indian patients with tinea cruris and tinea corporis.
A cross sectional study optimizing platelet rich plasma preparation using various centrifugation speeds and its effects on the platelet yield
Authors: Makwana Vaishali Sanket , Rachchha Zeal Jayeshbhai , Lathiya Sandip Labhubhai , Pandya Nehalben Manishbhai 
Published: September 2024

Platelet-rich plasma (PRP) is an autologous preparation of platelets in concentrated plasma (with usually &#62;1,000,000 platelets/μL or 2–7 times the concentration in whole blood), prepared by a process known as differential centrifugation. The therapeutic efficacy of a PRP preparation is largely determined by its platelet concentration. Although PRP has been used for many years, there is no standard preparation protocol. This study was conducted to compare different protocols to determine which spin variation produces the highest platelet yield.A cross sectional study was conducted at a tertiary care hospital with 35 patients. We included the data of the patients that were enrolled in PRP therapy for various dermatological indications. We analysed the data for PRP prepared using different centrifugation protocols and then compared the platelet count of PRP with the baseline platelet count of whole blood to obtain the platelet yield. The platelet yields for different protocols were compared using statistical analysis (IBM SPSS software).After comparing the platelet yield of different protocols, we observed that centrifugation at 1300rpm/246 g for 20 minutes followed by 1600 rpm/373 g for 20 minutes achieved the highest platelet yield-4.6468 times as compared to the mean platelet count in the whole blood and the difference was statistically significant.Multiple parameters influence the platelet concentration obtained in PRP. Therefore, the practitioner must consider the method of PRP preparation that gives the optimum platelet yield to deliver the best therapeutic results to the patients.
Anhydrotic ectodermal dysplasia at tertiary care centre in western region of India
Authors: Rime Monica , Modha Jay Dhirajlal , Bhuptani Neela V , Patel Bharti K 
Published: September 2024

Anhydrotic Ectodermal Dysplasia, a rare genodermatosis, results in developmental anomalies affecting structures derived from the ectoderm. This condition is characterized by a clinical triad encompassing hypodontia, hypotrichosis, and anhidrosis, alongside additional symptoms Anhydrotic. We conducted a retrospective review of the medical records of patients diagnosed with Anhydrotic Ectodermal Dysplasia at the Department of Dermatology, PDU Govt Medical College and Hospital Rajkot over the duration of 14 years from june 2008 to june 2022 Clinical presentations, family history details, and the initial symptoms prompting medical attention were carefully documented.In this case series,total 6 patients 5 males and 1 female of Anhydrotic Ectodermal dysplasia were identified. Clinical triad was present in all the patients. Family history was positive in 5 patient where 2 males were from the same family. Three patients were born out of consanguineous marriage.Initial presentations most commonly noted were intolerance to heat, recurrent fever, dry skin and abnormal dentition. Anhydrotic Ectodermal dysplasia is a rare genodermatoses which is invariably characterized by its clinical triad. Early diagnosis is important in order to improve the quality of life.
Evaluating the use of an advance lotion for addressing skin hyperpigmentation
Authors: Choudhary Sanjay , Joshi Rajiv , Sen Dyotona 
Published: September 2024

Localized hyperpigmented spots on the skin can cause concern due to their associated aesthetic implications. Skin types higher on the Fitzpatrick scale are particularly more susceptible to the development of hyperpigmentation. Several studies focusing on the pathophysiology of hyperpigmentation reveal that exposure to ultraviolet radiation can trigger or further exacerbate the condition. Many topical formulations are available in the market, consisting of either individual or a combination of agents. Of late, there has been an increased interest in botanical extracts as safer alternatives to traditional skin-brightening agents. However, there is a paucity of human trials evaluating the outcomes associated with such combination products.This study examined the efficacy and safety aspects related to the use of Advance Lotion, which contains , licorice, kojic acid, arbutin, and vitamin E as key ingredients, for addressing skin hyperpigmentation. The outcomes were evaluated using instrumental variables that are well-established indicators of skin pigmentation and based on self-assessment by study participants. The results revealed a significant reduction in skin pigmentation and cumulative improvements upon the continued use of Advance Lotion. There were no associated cases of skin intolerance as observed in the clinical examination or reported by the study participants. These promising results indicate the effectiveness of this product in visibly reducing pigmentation.
A study of functional outcome of bimalleolar fracture with syndesmotic injury after open reduction and internal fixation in young adults
Authors: Thoudam Solemn , Sharma Yogesh , Garg Rahul , Das Samay , Kevadiya Milan , Gupta Aniket 
Published: September 2024

Malleolar injuries when combined with syndesmotic injuries are widely regarded as some of the most common and severe fractures that affect the lower extremities. These injuries are of great significance because the ankle joint bears the weight of the body, making it prone to instability and difficulty in locomotion. Open reduction and internal fixation have become the preferred treatment option for the majority of unstable bimalleolar fractures, as this surgical method restores the ankle's anatomy, biomechanics, and contact loading characteristics.Prospective study of 20 patients of bimalleolar fracture was done in MMIMSR, Mullana, Ambala who were surgically managed by TBW/screw for medial malleolus fixation and plating for fibula.: According to Baird and Jackson scores, out of 20 cases 65% had good to excellent result, 55% had fair result and 10% had poor functional outcomeAchieving accurate anatomical reduction, restoring articular congruity, and timely surgical fixation using appropriate implants can lead to favourable functional outcomes.
Functional and radiological outcome of using proximal femoral nail for intertrochanteric fractures of femur among geriatric population in a tertiary care hospital: An evaluation study
Authors: Srinivasan Velmurugan , Pandiyan Saravana , Priya Hema 
Published: September 2024

The intertrochanteric (IT) fracture of the femur is an extra-capsular fracture that occurs between the greater and lesser trochanters. The introduction of proximal femoral nailing (PFN) is one of the fixation modalities for proximal femoral fractures that has shown positive results with relatively lesser intraoperative complications and considerably low post-operative complication rates. Hence, this study intends to analyse the functional and radiological outcomes of proximal femur fractures surgically managed with Proximal Femoral Nail.A prospective study was done among 45 patients above 65 years from June 2022 to June 2023. The functional outcome was measured by Harris Hip Score (HHS), the radiological outcome by the time of fracture union, and the pain scores by Visual Analogue Scale (VAS). Patients were followed up at regular intervals for 6 months post-surgery. There were no post-operative complications observed. The average time of union was 18.5 (±4.1) weeks. The mean HHS and VAS Score at the end of 6 months was 86.978±4.0 and 0.4±0.49. The Comparison of mean VAS at different intervals was statistically significant. There was a significant association between age and VAS scores at 6 weeks, 3 months, and 6 months.PFN has the advantage of requiring shorter exposure time and a lower likelihood of morbidity and operating time. Thus the treatment of intertrochanteric fracture with PFN has a more favourable outcome and it is one of the implants of choice for intertrochanteric fractures at present.
Effect of posterior femoral condylar offset (PCO) on clinical results of multi-radius (MR) femoral design implant/component in posterior stabilized total knee arthroplasty (PS TKA)
Authors: Patni Aaditya , Mahawar Deep Kunwar , Dodiyar Piyush 
Published: September 2024

When a posterior condylar offset (PCO) is properly reconstructed in a Total Knee Arthroplasty (TKA), a larger posterior clearance can be achieved, which helps delay impingement posteriorly and maximizes the range of flexion (ROF). This study was conducted to investigate the effect of PCO on clinical outcomes using Multi-radius (MR) femoral design components in PS TKA. This hospital-based prospective observational study was conducted between January 1, 2018, and December 31, 2018, with a 6-month follow-up. A total of fifty patients were operated on with a MR PS design. The PCO, flexion, and knee society scoring (KSS) system were measured preoperatively and postoperatively.: The average age of the patients was 66.8 (range 58.3 to 75.3) years. The average preoperative and postoperative PCO was 27.5 (range 25.3 to 29.7) and 29.2 (range 26.2 to 32.2) mm, respectively. The average preoperative and postoperative non-weight-bearing flexion was 106.5 (range 93.7 to 119.3) and 119.9 (range 116.6 to 123.2) degrees, respectively. The average preoperative and postoperative weight-bearing flexion was 96.7 (range 86.6 to 106.8) and 123.6 (range 120.7 to 126.5) degrees, respectively. The average preoperative KSS knee score was 55.9 (range 52.6 to 59.2), and the average preoperative KSS function score was 29.4 (range 17.3 to 41.5). The average postoperative KSS knee score was 83 (range 80.5 to 85.4), and the average postoperative KSS function score was 83.2 (range 78.5 to 87.9). Among them, sixteen knees (32%) showed excellent KSS knee and function scores, while 34 knees (68%) showed good scores. There were statistically significant differences for all variables.: There was a significant increase in PCO, flexion (both weight-bearing and non-weight-bearing), KSS knee score, and function scores.
Management and outcome of gap non-union of tibia by ilizarov ring fixator
Authors: Pandey Divyam , Sharma Jayant , Shukla Abhishek Kumar 
Published: September 2024

Road traffic accidents are of growing public health importance worldwide, contributing significantly to the global disease burden. Associated bone tissue defect and infection, commonly result in development of infected non-union. Non-union of long bones especially tibia when associated with infection has always been a challenge to orthopaedic surgeons. Bony union is not usually contained until the infection has been eradicated and there are usually coexisting problems of deformity. The objective of the study was, to evaluate Ilizarov fixator method in the treatment of gap non-union. A descriptive study was conducted on 25 patients admitted in Orthopaedic Department of Index Medical College, Hospital & Research centre, Indore from November 2022 to February 2024. Pre operative & post operative x-rays were done in each case. Debridement followed by fixator assembly and Uni-focal or bi-focal osteotomy followed by transport was done. Out of 25patients, 23 were male and 2 were female. The mean age of patients was 38years, with 60% being in 30-40years age group. The patients with grade II open fractures 11, grade IIIA were 6, grade I were 5 and patients with closed fracture were 3. Maximum of non-union were in the region of diaphysis and metaphysis. Our results showed that 76% of the patients has excellent or good results, of bone union. There were 48% excellent, 28% good, 16% fair and 08% poor functional results in our study. There were no failures in our study. Most common post-operative complications we came across is pin tract infection and equinus. Nearly all the complications were managed and outcome was good in these cases except for 2 cases wherein there were non-union, in which results were poor. Ilizarov ring fixator is an excellent treatment modality for gap non-union of tibia, in terms of union.
Spirituality in the Workplace: Enhanced Job Satisfaction Through Employee Well-being and Work-life Balance
Authors: Nikensari Galuh Amilia , Yudhistira Putu Gde Arie 
Published: September 2024

Objective: This study examines the relationship between workplace spirituality and job satisfaction mediated by employee well-being and moderated by work-life balance in the travel industry.
Design/Methods/Approach: The data was collected using a questionnaire using purposive sampling. A total of 415 respondents working in conventional travel agent services participated in the study. Data analysis was performed using the Partial Least Square Structural Equation Model (PLS-SEM) via outer and inner models using SmartPLS 4.
Findings: This study identifies that workplace spirituality positively has a direct and indirect impact on job satisfaction with the mediating effect of employee well-being and the moderating effect of work-life balance.
Originality/Value: The study provides new insights by examining both the direct and indirect impacts of workplace spirituality on job satisfaction within the travel agent industry. The study also identifies the moderating effect of work-life balance and the mediating effect of employee well-being formulated into a comprehensive model.
Practical/Policy implication: This study provides managerial implications, suggesting managers can leverage workplace spirituality as a competitive advantage. Managers can enhance employees' job satisfaction by implementing well-being programs that consider employees' spiritual needs and work-life balance.
Stress-related psychosocial intervention among pregnant woman with history of miscarriage: A scoping review
Authors: Karisa Putri , Rukmasari Ema Arum , Al Fajar Muhamad Gustaf 
Published: September 2024

Introduction: Miscarriage is a traumatic experience for the mother and can lead to stress due to lack of family and social support. This event can be harmful to the woman as it can lead to pregnancy trauma and more severe psychological disorders such as depression and suicide. Providing psychosocial support to women experiencing miscarriage can be a positive supportive care option. This article aimed to identify psychosocial interventions to reduce stress levels in pregnant women with a history of miscarriage.
Method: A scoping review was conducted using PubMed, Google Scholar, Science Direct, and SAGE Journal databases. Keywords used include psychosocial intervention, stress level, and pregnancy. Articles were selected based on the criteria of publication year 2017-2022, English language, randomized controlled trial research design and research results according to the topic.
Results: The results obtained 6 articles that met the criteria. Psychosocial interventions to reduce stress levels in pregnant women with a history of miscarriage can be done through mindfulness therapy, supportive care, family support, brief supportive psychotherapy, cognitive narrative intervention, and happiness counseling programs.
Conclusions: Psychosocial-based interventions can be used as supportive therapy to improve the psychological well-being of women with a history of miscarriage.
Keywords: miscarriage; pregnancy; psychosocial intervention; stress level
Choice of Acromioclavicular Dislocation Treatment Should Not Be Influenced by Risk of Development of Acromioclavicular Osteoarthritis
Authors: Vossen Roderick J.M. , Verstift Daniel , Van Etten-Jamaludin Faridi S. , Hamans Bryan J. , van den Bekerom Michel P.J. , Verweij Lukas P.E. 
Published: September 2024

Background:
It is currently unknown to what degree surgical or nonoperative treatment of acromioclavicular (AC) dislocation influences the development of osteoarthritis (OA). The aim of this study was to evaluate AC OA after surgical and nonoperative treatment for AC dislocations, compare OA prevalence between treatment options, and compare OA prevalence between the injured and contralateral shoulder.

Methods:
Articles reporting on the prevalence of OA after surgical or nonoperative treatment of an AC dislocation with a minimal 2-year follow-up were included. AC OA presence was extracted for the injured and contralateral shoulder. Treatment categories were defined based on anatomical variation in the reattachment of ligaments: AC fixation, coracoclavicular (CC) fixation, AC and CC fixation, Bosworth screw synthetic graft, tendon graft, and conservative. Study quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS) criteria.

Results:
Ninety-four articles were included for qualitative analysis, and 7 articles were included for meta-analysis (n = 3,812; follow-up = 2.0-24.2 years; mean age 37.6 ± 10.4 years). A total of 3,483 patients underwent surgical treatment, and 329 patients underwent conservative treatment. OA prevalence ranged from 6.7%-29.3% between 7 pooled treatment categories. Most included studies had a follow-up <10 years (94%) and OA prevalence increased with time, regardless of treatment option. There was no difference in OA prevalence between the injured and contralateral shoulder (p = 0.120). MINORS scores were varied, ranging from poor to very good.

Conclusion:
The pooled AC OA prevalence of the 7 treatment categories ranged from 6.7% for the CC fixation surgical group to 29.3% for the conservative treatment group. However, the included studies were predominantly of low quality and had varying follow-up periods, with most having relatively short follow-up durations. No difference in AC OA prevalence was found between the injured and contralateral shoulder. Based on the available evidence, treatment choice for AC dislocation should not be influenced by the potential development of AC AO.

Level of Evidence:

Level IV. See Instructions for Authors for a complete description of levels of evidence.
Water-Alternating CO2 Injection in Carbonate Reservoirs: A Review of Fluid-Rock Interaction Studies
Authors: Marçon Diogo Reato , Iglesias Rodrigo Sebastian , Novaes Aline Machado de Azevedo , de Faria Rafaella Magliano Balbi 
Published: September 2024

SummaryWater-alternating-CO2 (CO2-WAG) injection is a well-established method for enhanced oil recovery (EOR) and a promising option for geological carbon storage. The alternating injection of this gas with water also increases carbonate rock reactivity, which is higher than that in siliciclastic reservoirs, affecting the porosity and permeability near the well, thereby impacting the injectivity and well integrity. The composition of the produced water is also affected, increasing the potential for inorganic scaling. Moreover, reactivity also changes the pH of the produced water, thereby affecting material selection for producer wells. The characterization and modeling of such fluid-rock interaction effects are challenging but valuable for designing and optimizing the CO2-WAG process. To assess the current knowledge on this topic, we present a review encompassing laboratory- and field-scale studies of fluid-rock interactions resulting from CO2-WAG processes, particularly those pertaining to changes in the porosity, permeability, and produced water composition. Numerous studies within this scope have been published. This review summarizes the most pertinent findings and identifies opportunities for further research. In laboratory-scale studies, the main necessity is to expand the range of experimental conditions and parameters, either by conducting experiments with different mineralogies under representative reservoir conditions (e.g., pressure, temperature, and hydrodynamics) or by incorporating an oil phase, as such studies yield data essential for field-scale simulations, thereby enhancing their reliability. Addressing gaps in field-scale studies involves integrating the phenomenon of relative permeability hysteresis when assessing the impact of carbonate rock dissolution on the injectivity during CO2-WAG, as these phenomena are concurrent. Finally, we advocate for studies that establish an upscaling methodology for translating laboratory results into field-scale reactive transport simulations.