bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pd/Mengphos-Catalyzed High-Order [4+4] Cycloaddition for Efficient Synthesis of Oxazocines
Authors: Meng Yinggao , Han Xin , Xu Mengya , Xia Yingying , Mei Huiwen , Bi Xiucheng , Zhou Xin 
Published: October 2024

AbstractThe development of new catalytic systems that enable regio- and chemoselective construction of diversely functionalized oxazocines is an important topic in organic synthesis and pharmacochemistry. Herein, a novel Pd/Mengphos complex was designed and applied in a palladium-catalyzed high-order [4+4] cycloaddition of 2-substituted allylic carbonates to α,β-unsaturated imines, allowing facile access to versatile oxazocines in good yields with excellent b/l and Z/E selectivities (up to 92% yield and complete b/l and Z/E selectivities). The reaction exhibited a broad substrate scope, mild reaction conditions, and good functional group compatibility. In addition, an asymmetric version has also been tested, affording the desired oxazocines in moderate to good enantioselectivity.
19F-Labeled NMR Probes for the Detection and Discrimination of Nitrogen-Containing Analytes
Authors: Zhao Yanchuan , Gu Guangxing , Wang Chenyang 
Published: October 2024

AbstractThe development of 19F-labeled NMR probes has become a pivotal tool in analytical chemistry. Recent advancements in probe design enable precise identification of nitrogen-containing analytes, significantly enhancing the analysis of these biologically important analytes in complex mixtures. This short review highlights recent progress with probes based on covalent derivatization and dynamic exchange strategies, which yield distinct 19F NMR signals for each nitrogen-containing analyte. These strategies facilitate separation-free multicomponent analysis and chiral discrimination. Discussions will cover design principles, scope, limitations, and strategies to enhance the sensitivity and resolving ability. By addressing current challenges, 19F-labeled NMR probes hold the potential to revolutionize the detection of biologically relevant molecules, catalyzing new discoveries in chemical and biochemical research.1	Introduction2	19F-Labeled Probes Based on Covalent Derivatization2.1	Non-Chiral 19F-Labeled Probes Based on Covalent Derivatization2.2	Chiral 19F-Labeled Probes Based on Covalent Derivatization3	19F-Labeled Probes Based on Dynamic Ligand Exchange3.1	Non-Chiral 19F-Labeled Probes Based on Dynamic Ligand Exchange3.2	Chiral 19F-Labeled Probes Based on Dynamic Ligand Exchange4	Conclusion and Outlook
Chemical Capture and Sensing of Bovine Serum Albumin with Phenothiazinylcarbaldehyde-Labeled 2′-Deoxyuridine
Authors: Bag Subhendu , Kapdi Anant R. , Sahu Rajesh , Sanghvi Yogesh S. , Gunturu Krishna Chaitanya 
Published: October 2024

AbstractChemical-capture-mediated sensing has had a great impact on proteomic research. Toward this end, we demonstrate the chemical trapping of BSA by the reactive formyl functionality of a newly developed fluorescent nucleoside probe, formylphenothiazine-labeled-2′-deoxyuridine. The probe is capable of trapping BSA via Schiff base formation leading to fluorescence ‘switch-on’ sensing with a large hypsochromic shift of ca. 100 nm. The α-amylase does not show any significant change in fluorescence response, demonstrating the efficiency of the probe in selective sensing of BSA. Docking studies suggest the preferential interaction of the phenothiazinylcarbaldehyde-labeled dU with the residual amino acids in site I of the BSA protein as compared to site II.
Visible-Light-Mediated Photoredox Radical Cyclization Reaction with Alkyl Boronic Acids Using Molecular Oxygen as a Sole Oxidant
Authors: Wang Xia , Gui Qing-Wen , Qin Xuanlin , Yan Jingting , Guo Li , Yao Jie , Shang Yanxue , Liu Yuxuan , Chen Xi 
Published: October 2024

AbstractIndolo[2,1-b]quinazolin-12(6H)-one derivatives are prevalent in many synthetic intermediates, pharmaceuticals, and organic materials. Herein, we developed a photoredox radical cascade cyclization reaction that uses visible light as the primary energy input to promote the reaction, leading to a series of indolo[2,1-b]quinazolin-12(6H)-one derivatives under oxygen conditions.
Protective Effect of Lavandula officinalis on Pentylenetetrazol-Induced Epilepsy in Mice: Expression of NOS Genes and Caspase-3
Authors: Ahghari Parisa , Afshar Saeid , Dastan Dara , Yazdi Amirhossein Ahmadieh 
Published: October 2024

Abstract
Objective Given the incidence of epilepsy and the adverse effects of unconventional antiepileptic medicines, there is a need for a novel medical treatment strategy for epileptic patients.
Materials and Methods The current study involved the selection of 80 male mice, which were then separated into 10 experimental groups: pentylenetetrazol (PTZ), negative control which received normal saline, treatment which received Lavandula officinalis in two doses of 200 and 400 mg/kg, L. officinalis 200 mg/kg and 1400 w, L. officinalis 200 mg/kg and 7-NI, L. officinalis 200 mg/kg and diphenylene iodonium chloride (DPI), L. officinalis 400 mg/kg and 1400 w, L. officinalis 400 mg/kg and 7-nitroindazole (7-NI) and group which received L. officinalis 400 mg/kg and DPI. Each group was stimulated with an 11-day injection cycle (every 48 hours) of PTZ at a dosage of 35 mg/kg. All groups underwent PTZ challenge dosage (75 mg/kg) testing during the 12th injection. Ultimately, the brains of all mice were extracted, and the activity of genes related to neuronal nitric oxide, inducible nitric oxide, and endothelial nitric oxide was assessed. The enzyme-linked immunosorbent assay (ELISA) method was used to assess the quantity of caspase-3 in the groups.
Results Lavandula officinalis decreased the severity of seizures. The findings of our study demonstrated that the extract had a suppressive effect on the expression of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; p < 0.05), while it had a stimulatory effect on endothelial NOS (eNOS; p < 0.05). In addition, L. officinalis reduced caspase-3 levels in the groups who were administered the extract.
Conclusion The hydroalcoholic extract of L. officinalis has been found to be effective. Lavandula officinalis enhanced the expression of endothelial nitric oxide and reduced the levels of neuronal and inducible nitric oxide to a greater extent in brain tissue affected by epilepsy. The groups receiving extract derived from L. officinalis exhibited a reduction in the level of caspase-3.
The Potential Impact of Heat on Athletes' Sleep at the Paris 2024 Olympics and Paralympics Games
Authors: Rosa João Paulo Pereira , Silva Andressa , Lira Claudio Andre Barbosa de , Mello Marco Tulio de 
Published: October 2024

AbstractIn 2024, Paris will host the Olympic (during July and August) and Paralympic (during September) Summer Games. Despite temperatures often exceeding 40°C in Paris in July, the International Olympic Committee (IOC) has indicated that there will be no installation of air conditioning in the athletes' rooms. High ambient temperatures can impair the quantity and quality of sleep and, consequently, impair athletic performance. In this overview, we present the rationale behind and explain the process of how a warm environment is unfavorable to the sleep of Olympic and Paralympic athletes, as well as offer practical recommendations on how to mitigate the effects of environment heat for a restful and effective night's sleep during the Paris 2024 Olympics and Paralympics Games.
Lifetime Violence and Perinatal Sleep Quality: A Scoping Review
Authors: Agarwal Nandini , Halim Nafisa 
Published: October 2024

Abstract
Introduction In-utero experience of violence through maternal experience of intimate partner violence (IPV) is a risk factor for adverse pregnancy outcomes via ‘biological programming,’ whose effect can be mediated by sleep. We conducted a scoping review to synthesize the current evidence of the association between experiences of violence and sleep in women.
Methods Between August and October 2023, we conducted a search in four databases (PubMed, APA PsycInfo, Embase, and Web of Science) for peer-reviewed articles, using 11 inclusion and exclusion criteria. Any study published in English in peer-reviewed journals that conducted original research on the association between exposure to violence (lifetime IPV, IPV during the previous year, during and 1 year after pregnancy, as well as adverse childhood experiences) and poor sleep outcomes (sleep disturbances, insomnia, poor sleep quality, and longer time to fall asleep) in the perinatal population were included.
Results The synthesis of the 12 included studies revealed a positive association between exposure to violence and poor sleep, and between adverse childhood experiences and sleep disturbances or poor sleep during pregnancy. Moreover, IPV in the postpartum period was associated with poor sleep.
Conclusion Most of the evidence synthesized comprises data from high-income countries, resulting in lack of cultural context. However, it is evident that the experience of violence throughout life is a risk for poor perinatal sleep quality. Thus, there is a growing need to study this association, especially in resource-limited settings, where data on sleep health is largely absent, inform pregnancy care and maternal and child health policies.
Prescribing Pattern and Medication Adherence in Patients with Epilepsy in a Tertiary Neuro-Center, Kathmandu
Authors: Pant Poonam , Thapa Sarita , Karkee Shiba Bahadur , Pandey Sudip 
Published: October 2024

AbstractBackground Epilepsy is a chronic condition characterized by unusual, frequent, excessive, and self-terminating neuronal firing. Adherence to medication is crucial to achieve the intended therapeutic outcome. However, not much research has been done on drug adherence in our context. Thus, the purpose of this study is to investigate the antiseizure medication prescribing pattern, medication adherence, and associated factors.Materials and Methods A cross-sectional, analytical research was done on randomly selected epileptic patients through interview and documentary analysis using a semi-structured interview schedule and the eight-item Morisky Medication Adherence Scale (MMAS-8). The clinical and demographic characteristics were described using descriptive statistics (median, interquartile range [IQR], frequency, and percentage). The Shapiro–Wilk and chi-squared tests were used to examine the factors influencing medication adherence and the relationships between research variables. The analysis was performed using SPSS version 16.Results From a total of 104 patients, 77.3% were males, the median age was 29 years (IQR: 16), the majority (42.3%) had higher secondary education, 15.4% had secondary education and 5.8% were illiterate, 25% were job holders, 26% were laborers, 41.3% were from province 3, and 16.3% were from province 4. Two-thirds (63.5%) of the patients were highly adherent to antiseizure medication and 54.8% were seizure free for more than 2 years.The most common type of epilepsy diagnosed was generalized epilepsy (54.8%). Seizures were usually treated with monotherapy (65.4%), with sodium valproate being the most often used single antiseizure medicine (26.8%), followed by carbamazepine (16.3%) and levetiracetam (15.4%). Additionally, sodium valproate was the medication most frequently used in polytherapy for epilepsy. There was a strong association established between adherence and drug therapy type, age, adverse drug reaction, and seizure control. The study revealed that adherence was not significantly associated with factors such as gender, occupation, regional distribution, or type of epilepsy.Conclusion Low adherence was observed in 36.5% of patients. As a significant association was observed between medication adherence and seizure control, health care providers should focus on improving medication adherence. Evaluation of adherence needs to be a regular component of managing epilepsy. Further patients who do not stick to their drug regimens should receive more attention and assistance. It will support better therapy results.
Is Trochlear Dysplasia Associated with a High Prevalence of Repaired Anterior Medial Portal Lesions in Anterior Cruciate Ligament-Deficient Knees?
Authors: Kumar Naveen , Ghimire Pradip , Shukla Shrikant , Meena Pradeep Kumar , Saxena Sudhir , Saran Sonal 
Published: October 2024

Abstract
Introduction Meniscal tears, especially in the medial meniscus, are common in anterior cruciate ligament (ACL) injuries. Repaired anterior medial portal (RAMP) lesions, specific meniscal injuries associated with ACL ruptures, affect the peripheral attachment of the posterior horn of the medial meniscus. While the relationship between femoral trochlear morphology and ACL tears is established, its association with RAMP lesions remains unexplored. This study investigates the association between femoral trochlear morphology and RAMP lesions in ACL-deficient knees using magnetic resonance imaging (MRI) and evaluates MRI's accuracy against arthroscopy.
Methods This hospital-based, cross-sectional observational study was conducted in a tertiary care center over 18 months. It included 126 adult patients who underwent arthroscopic ACL reconstruction and had preoperative MRI. Variables included age, gender, body mass index, trauma nature, and various MRI parameters, including femoral trochlear morphology and presence of RAMP lesions. MRI findings were compared to arthroscopic findings to evaluate diagnostic accuracy.
Results RAMP lesions were detected in 21 participants (16.7%) via MRI and 28 participants (22.2%) via arthroscopy. MRI showed 71.4% sensitivity and 99.0% specificity for detecting RAMP lesions. No significant association was found between femoral trochlear morphology and RAMP lesions. However, medial tibial slope (TS) and posterior medial tibial bone edema (PMTBE) were significantly associated with RAMP lesions. The agreement between MRI and arthroscopy was high (Cohen's kappa = 0.773, p < 0.001).
Conclusion This study found no significant association between femoral trochlear morphology and RAMP lesions in ACL-deficient knees. Instead, medial TS and PMTBE were significant predictors. MRI proved to have high specificity but moderate sensitivity compared to arthroscopy.
A Case of Coronary Artery Aneurysm Occurring After Drug-Coated Balloon Intervention for De Novo Chronic Total Occlusion
Authors: Syah Pangeran Akbar , Loong Chong Wei , Dewangga Raditya , Wibawa Kevin , Sumajaya I Dewa Gde Dwi , Liew Houng Bang 
Published: October 2024

AbstractDrug-coated balloons (DCBs) have been proposed as a viable alternative to drug-eluting stents (DES) for managing chronic total occlusion (CTO), reducing adverse reactions associated with DES. However, adverse events after DCB treatment are rarely reported. We present a case of coronary artery aneurysm (CAA) formation after DCB treatment. A 55-year-old active smoker presented with exertional chest pain and positive ischemic response on the exercise stress test. Diagnostic coronary angiography revealed CTO in the mid-left anterior descending (mid-LAD) coronary artery with collateral circulation arising from the contralateral side. The patient underwent DCB treatment using a paclitaxel-coated balloon after predilatation with a noncutting balloon and a semi-compliant balloon. The final angiogram showed minimal recoil, type B coronary dissection nonflow limiting, and thrombolysis in myocardial infarction (TIMI) grade 3 flow. A follow-up coronary angiogram at 6 months revealed a fusiform aneurysm at the treated lesion with DCB. Despite the asymptomatic nature of the patient, good distal flow in the LAD, and the patient achieving a TIMI grade 3 flow, a decision was made to observe and closely monitor the patient. Despite potential risks, DCB remains a viable alternative to DES in CTO cases. Our case suggests that, although CAA occurred, it did not lead to significant adverse cardiac events. Further research is needed to understand the predictors and long-term outcomes of CAA.
Thrombosis in Antiphospholipid Syndrome: Current Perspectives and Challenges in Laboratory Testing for Antiphospholipid Antibodies
Authors: Devreese Katrien M.J. 
Published: October 2024

AbstractAntiphospholipid syndrome (APS) diagnosis hinges on identifying antiphospholipid antibodies (aPL). Currently, laboratory testing encompasses lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2-glycoprotein I antibodies (aβ2GPI) IgG or IgM, which are included in the APS classification criteria. All the assays needed to detect aPL antibodies have methodological concerns. LA testing remains challenging due to its complexity and susceptibility to interference from anticoagulant therapy. Solid phase assays for aCL and aβ2GPI exhibit discrepancies between different assays. Antibody profiles aid in identifying the patients at risk for thrombosis through integrated interpretation of all positive aPL tests. Antibodies targeting domain I of β2-glycoprotein and antiphosphatidylserine–prothrombin antibodies have been evaluated for their role in thrombotic APS but are not yet included in the APS criteria. Detecting these antibodies may help patients with incomplete antibody profiles and stratify the risk of APS patients. The added diagnostic value of other methodologies and measurements of other APS-associated antibodies are inconsistent. This manuscript describes laboratory parameters useful in the diagnosis of thrombotic APS and will concentrate on the laboratory aspects, clinical significance of assays, and interpretation of aPL results in the diagnosis of thrombotic APS.
A History of the Eastern Economic Association: 50 Years of Finding Space for Pluralism and Inclusion in Economics
Authors: Small Sarah F. , Beltran Figueroa Laura , Masci Leah , Mehrish Nishu , Riddiford Graham Iris , Pressman Steven 
Published: October 2024

AbstractDrawing on archival data and oral histories, this paper examines the history of the Eastern Economic Association from its beginnings in 1974 to its 50th anniversary in 2024. It sheds light on the ideological, social, and political motivations behind the EEA’s founding, focusing on its commitment to addressing the narrowness of the economics profession and the marginalization of women and underrepresented minorities. It also documents some of the problems that the Eastern Economic Association and the Eastern Economic Journal faced over time and how they have resolved these problems. Based on this history and analysis, the paper contributes to a deeper understanding of the EEA’s enduring impact on the field of economics and its continuing relevance in fostering a more inclusive and pluralistic academic community.
Simultaneous co-axial multi-modal inspection using a laser driven x-ray and neutron source
Authors: Armstrong C. D. , Scott G. G. , Richards S. , Fedorov K. , Laker-Illoul A. , Hull G. , Patel J. K. , Booth N. , Clarke R. , Rajeev P. P. , Simpson R. , Ma T. , Hernandez-Gomez C. 
Published: October 2024

Laser-plasma interactions have been demonstrated to produce bright sources of energetic radiation including ions, electrons, photons across the electro-magnetic spectrum, and neutrons. Combinations of species can significantly increase information from non-destructive imaging. Here we demonstrate single-shot co-axial radiography with both x-ray and fast-neutron radiation from a laser-driven source using a pair of gated microchannel plate photomultiplier tube channels and a fast scintillator medium. The outlined system demonstrates recovery full-width-half-maximum of (18 ± 3) ns, which is sufficient to isolate x-rays from neutrons up to (72 ± 20) MeV and could be isolated only a short distance (2 m) from the target.
InP-based strain engineered InAs(Sb)/InAsPSb multiple quantum wells with tunable emission and high internal quantum efficiency enabled by Sb incorporation
Authors: Nguyen P. D. , Kim D. , Jung H. J. , Kang T. I. , Park S. , Kim J. S. , Chun B. S. , Lee S. J. 
Published: October 2024

A type I InAs(Sb)/InAsPSb strain engineered multiple quantum wells light emitting diodes system has been demonstrated. Tensile InAsPSb quantum barriers with a high degree of band offset (∆EC = 116–123 meV, ∆EV = 193–250 meV) were used to compensate for the high compressive strain of the InAs(Sb) quantum wells. The structure was grown on the n+-InAsxP1−x metamorphic buffer with a high degree of relaxation (98%), low surface roughness (0.69 nm), and low dislocation density. Through careful strain engineering design, the compressive strain of InAs(Sb) reaches 0.57%–1.52% without strain relaxation. The incorporation of Sb into the multiple quantum wells not only reduces the bandgap but also improves the interface quality by acting as an effective surfactant. Structural analysis reveals superior quality in InAsSb/InAsPSb multiple quantum wells compared to InAs/InAsPSb multiple quantum wells, demonstrating significantly reduced interface roughness and suppression of the Stranski–Krastanov growth mode. Room temperature electroluminescence measurements show a tunable emission wavelength ranging from 2.7 to 3.3 μm, accompanied by a narrow full width at half maximum value of 45 meV. Photoluminescence analysis indicates that the internal quantum efficiency of InAsSb/InAsPSb multiple quantum wells is 5.5%, which is 7 times higher than that of InAs/InAsPSb.
Phase-selective growth of κ- vs β-Ga2O3 and (InxGa1−x)2O3 by In-mediated metal exchange catalysis in plasma-assisted molecular beam epitaxy
Authors: Ardenghi A. , Bierwagen O. , Lähnemann J. , Luna E. , Kler J. , Falkenstein A. , Martin M. , Sacchi A. , Mazzolini P. 
Published: October 2024

Its large intrinsic polarization makes the metastable κ-Ga2O3 polymorph appealing for multiple applications, and the In-incorporation into both κ and β-Ga2O3 allows us to engineer their bandgap on the low-end side. In this work, we provide practical guidelines to grow thin films of single phase κ-, β-Ga2O3 as well as their (InxGa1−x)2O3 alloys up to x = 0.14 and x = 0.17, respectively, using In-mediated metal exchange catalysis in plasma-assisted molecular beam epitaxy (MEXCAT-MBE). The role of substrate temperature, oxidizing power, growth rate, and choice of substrate on phase formation and In-incorporation is investigated. As a result, the κ phase can be stabilized in a narrow deposition window irrespective of the choice of substrate [(i) α-Al2O3 (0001), (ii) 20 nm of (2̄01) β-Ga2O3 on α-Al2O3 (0001), and (iii) (2̄01) β-Ga2O3 single crystal]. Low growth rates/metal fluxes as well as growth temperatures above 700 °C tend to stabilize the β-phase independently. Lower growth temperatures and/or O-richer deposition atmospheres allow to increase the In-incorporation in both polymorphs. Finally, we also demonstrate the possibility to grow (2̄01) β-Ga2O3 on top of α-Al2O3 (0001) at temperatures at least 100 °C above those achievable with conventional non-catalyzed MBE, opening the road for better crystal quality in heteroepitaxy.
Alternative and simple method to determine the refractive index of human dentin
Authors: Márquez-Islas Roberto , Mendiola-Rojas Diego , Pérez-Pacheco Argelia 
Published: October 2024

Determining a substance’s refractive index (RI) is of great importance in a wide variety of disciplines, such as chemistry, biomedicine, engineering, and optics, to name just a few. This work utilizes critical-angle reflectometry to measure the refractive index of dentin, a biological tissue characterized by its high RI and complex structure. We fabricated a hollow semicircular prism and filled it with bromonaphthalene (1-B), allowing us to measure RIs up to 1.65. We used 5 tooth samples with exposed dentin and a laser diode beam (λ = 650 nm) incident on interface 1-B/Dentine; the reflectance curve was measured from 60° to 75°. The critical angle is determined, and dentin RI is calculated. The real part of the calculated dentine’s RI coincided well with those determined by other more expensive and specialized techniques with high technical support.