bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring polyoxometalate speciation: the interplay of concentration, ionic strength, and buffer composition
Authors: Ždrnja Maja , Gumerova Nadiia I. , Rompel Annette 
Published: September 2024

This study investigates the concentration-dependent speciation and stability of Keggin-type [PVWVI12O40]3–(PW12) and Wells-Dawson type [α-PV2WVI18O62]6–(P2W18) polyoxotungstates across the pH range from two to eight and buffer systems including acetic acid-sodium acetate, citric acid-sodium citrate, sodium phosphate, Tris-HCl and HEPES. Utilizing 31P Nuclear Magnetic Resonance spectroscopy for detailed analysis, we quantified the stability and hydrolysis patterns of PW12 and P2W18 in various buffer solutions at concentrations of 3, and 15 mM, and compared with previously published data for 10 mM solutions. Our research shows that higher concentrations of PW12 and P2W18 in solutions improve their stability in neutral to moderately alkaline environments (pH seven and above), making them less prone to hydrolysis. This pronounced effect underscores the crucial role of concentration in optimizing the behavior of polyoxometalates under varying pH levels, revealing a strong link between concentration and stability across various buffers and highlighting how ionic strength, buffer composition, and pH crucially interact to influence POM stability. Research on how ionic strength affects the speciation of 3 mM solutions shows that the stability of P2W18 decreases as the pH approaches neutrality and as ionic strength increases, indicating heightened hydrolysis and reduced stability. For the inherently less stable PW12, the findings indicate a shift in hydrolysis pathways—different concentrations of the hydrolysis products, a change likely driven by the increased ionic strength. These findings emphatically underscore the critical importance of meticulously selecting the right buffer and concentration to fully unlock the potential of polyoxometalates such as PW12 and P2W18. Strategic choices are essential for leveraging these compounds as pivotal elements in groundbreaking applications, poised to revolutionize scientific and technological landscapes.
Design and synthesis new indole-based aromatase/iNOS inhibitors with apoptotic antiproliferative activity
Authors: Al-Wahaibi Lamya H. , Abou-Zied Hesham A. , Abdelrahman Mostafa H. , Morcoss Martha M. , Trembleau Laurent , Youssif Bahaa G. M. , Bräse Stefan 
Published: September 2024

The present study details the design, synthesis, and bio-evaluation of indoles 3–16 as dual inhibitors of aromatase and inducible nitric oxide synthase (iNOS)with antiproliferative activity. The study evaluates the antiproliferative efficacy of 3–16 against various cancer cell lines, highlighting hybrids 12 and 16 for their exceptional activity with GI50 values of 25 nM and 28 nM, respectively. The inhibitory effects of the most active hybrids 5, 7, 12, and 16, on both aromatase and iNOS were evaluated. Compounds 12 and 16 were investigated for their apoptotic potential activity, and the results showed that the studied compounds enhance apoptosis by activating caspase-3, 8, and Bax and down-regulating the anti-apoptotic Bcl-2. Molecular docking studies are intricately discussed to confirm most active hybrids’ 12- and 16-binding interactions with the aromatase active site. Additionally, our novel study discussed the ADME characteristics of derivatives 8–16, highlighting their potential as therapeutic agents with reduced toxicity.
Development of self-administered questionnaire on barriers, prescription practices, and guideline adherence of osteoporosis management among tertiary care clinicians: content validity and reliability analysis
Authors: Muhamad Jamil Nur Khadijah , Mohamed Isa Naina , Mokhtar Sabarul Afian , Leong Juzaily Fekry , Kamudin Nur Azree Ferdaus , Muhammad Norliza 
Published: September 2024

ObjectiveThis study outlined the development of the barriers, prescribing practices, and guideline adherence for osteoporosis management according to the Clinicians’ Osteoporosis Questionnaire (COQ) followed by an assessment of the content validity index and reliability test.MethodsThe development of the COQ was performed in two stages. Stage I involved the development of the COQ, and stage II involved judgmental evidence and quantification of the questionnaire. Five panel experts related to the study area and five clinicians participated in the validity of the COQ assessment. Fifty clinicians took part in the reliability test evaluation by filling out the questionnaire twice at 2-week intervals. The content validity index (CVI) and content validity ratio (CVR) were analyzed using Microsoft Excel, while Cohen’s kappa statistic was used to determine the test–retest reliability using SPSS version 29.ResultsForty items and three domains, namely, barriers, prescribing practices, and guideline adherence for osteoporosis management, were identified in the COQ (version 4.0). The scale-level CVI (S-CVI/Ave) for every domain was above 0.9, which is considered acceptable. The CVRs for all the items were above 0.7, except for two items in the barrier domain and two items in the guideline adherence domain. Two items were revised to improve the clarity of the item, and other items were retained based on consensus among the expert panel. Between the test and retest, the reliability of individual items ranged from moderate to almost perfect for the barrier domain (k = 0.42–0.86), prescribing practice domain (k = 0.79–0.87), and guideline adherence domain (k = 0.46–1). None of the items had “fair” or “poor” agreement. Thus, the 40-item COQ (version 4.0) was finalized following the content and face validity analysis.ConclusionsThrough an iterative process, the development and assessment of the COQ showed a high degree of content validity and reliability in measuring the barriers, prescribing practices, and guideline adherence among clinicians managing osteoporosis. Future studies should aim to further validate this instrument across different populations and settings, as well as explore methods to enhance its reliability and validity.
Chimeric antigen receptor T-cell therapy in relapsed or refractory mantle cell lymphoma: a systematic review and meta-analysis
Authors: Wan Haixiang , Weng Songqin , Sheng Sumei , Kuang Zilin , Wang Qingming , Hu Linhui 
Published: September 2024

BackgroundChimeric antigen receptor (CAR) T-cell therapy (CAR-T therapy) has demonstrated significant efficacy in the ZUMA-2 study. After regulatory approvals, several clinical trials and real-world studies on CAR-T therapy for relapsed or refractory mantle cell lymphoma (R/R MCL) were conducted. However, data on clinical safety and efficacy are inconsistent. In this study, we aimed to conduct a systematic analysis of the effectiveness and safety of CAR-T therapy across a wider and more representative cohort of patients with R/R MCL.MethodsWe performed a systematic review and meta-analysis of studies on patients with R/R MCL who received CAR-T cell therapy. Data were extracted and consolidated, with primary focus on the evaluation of safety and efficacy outcome measures. This study has not been registered with PROSPERO.ResultsThis meta-analysis identified and included 16 studies with 984 patients. The pooled estimate for overall response rate (ORR) was 89%; complete remission (CR) rate was 74%. The 6-month and 12-month progression-free survival (PFS) rates were 69% and 53%, respectively, while the overall survival (OS) rates were 80% and 69%, respectively. Cytokine release syndrome (CRS) of grade 3 or higher was observed in 8% of patients, whereas neurotoxicity of grade 3 or higher was observed in 22% of patients. The risk of bias was assessed as low in 9 studies and moderate in 7 studies.ConclusionCAR-T therapy exhibited promising efficacy and manageable adverse reactions in patients with R/R MCL.
Effect of propofol versus midazolam on short-term outcomes in patients with sepsis-associated acute kidney injury
Authors: Li Yuanjie , Guo Taipu , Yang Zhenkun , Zhang Rui , Wang Zhi , Li Yize 
Published: September 2024

BackgroundPropofol and midazolam are commonly used sedative drugs in mechanically ventilated patients in the Intensive Care Unit (ICU). However, there is still a lack of relevant studies exploring the influence of midazolam and propofol on the prognosis of patients with Sepsis-associated Acute Kidney Injury (S-AKI).Patients and methodsA statistical analysis was conducted on 3,745 patients with S-AKI in the Medical Information Mart for Intensive Care IV database. The patients’ baseline characteristics were grouped based on the use of either propofol or midazolam as sedatives. Cox proportional hazards models, logistic regression models, and subgroup analyses were used to compare the effects of propofol and midazolam on the short-term prognosis of S-AKI patients, including 30-day mortality, ICU mortality, and duration of mechanical ventilation.ResultsIn the statistical analysis, a total of 3,745 patients were included, with 649 patients using midazolam and 3,096 patients using propofol. In terms of the 30-day mortality, compared to patients using midazolam, S-AKI patients using propofol had a lower ICU mortality (hazard ratio = 0.62, 95% confidence interval: 0.52–0.74, p &lt; 0.001), lower 30-day mortality (hazard ratio = 0.56, 95% confidence interval: 0.47–0.67, p &lt; 0.001), and shorter mechanical ventilation time (odds ratio = 0.72, 95% confidence interval: 0.59–0.88, p &lt; 0.001). Kaplan–Meier curves showed lower survival probabilities in the midazolam group (p &lt; 0.001). Subgroup analyses showed that propofol was strongly protective of short-term prognosis in older, male, smaller SOFA score CCI score, no heart failure, and comorbid chronic kidney disease patients with S-AKI.ConclusionCompared to midazolam, propofol was considered a protective factor for short-term mortality risk and ICU mortality risk in S-AKI patients. Additionally, S-AKI patients using propofol had a lower risk of requiring prolonged mechanical ventilation. Overall, propofol may be more beneficial for the short-term prognosis of S-AKI patients compared to midazolam.
Utility of next-generation sequencing in identifying congenital erythrocytosis in patients with idiopathic erythrocytosis
Authors: Anžej Doma Saša , Kraljić Nika , Kristan Aleša , Debeljak Nataša , Maver Aleš , Pajič Tadej , Preložnik Zupan Irena 
Published: September 2024

BackgroundCongenital erythrocytosis (CE) is increasingly recognized as the cause of erythrocytosis in patients in whom polycythemia vera and secondary acquired causes have been excluded. The aim of our study was to determine possible genetic background in patients with idiopathic erythrocytosis.Methods40 patients with idiopathic erythrocytosis, referred to our institution in a 5-year period, were analyzed. We collected data on erythropoietin (Epo) levels, hemoglobin (Hgb), hematocrit (Hct), erythrocyte count, age, gender, past thrombotic events, concomitant diseases, and smoking status. CE was tested using next-generation sequencing (NGS), in the majority of patients also measurement of P50 and Hgb electrophoresis were performed. Patients with signs of iron overload were tested for genetic variants in the HFE gene.ResultsThe median patient age at analysis was 46.5 years (range 22–73), with 37 out of 40 being males (93 %). The median Hgb, Hct and red blood cells count were 180 g/L, 0.51, 5.985 x 1012/L in men and 171 g/L, 0.50 and 5.68 x 1012/L in women, respectively. Epo levels were decreased in three, increased in one patient and within the normal range in the rest (median 7.55 mIU/mL; range 2.90–19.50). Eight patients (20 %) smoked. 32 (80 %) were treated with low-dose aspirin, and 20 (50 %) underwent at least one phlebotomy. Thromboembolic events were recorded in 2 patients (5 %). P50 was measured in 20 out of 40 patients, and it was above 24 mm Hg (3.12 kPa) in all of them. Hemoglobin electrophoresis was performed in 73 % of patients, with no abnormal Hgb detected. Variants in the HFE gene were found in 8 out of 40 patients (20 %), but in only one patient the results were associated with an increased risk for hemochromatosis. Although no pathogenic variants for CE were detected by NGS, two variants of uncertain significance, namely EGLN1 (NM_022051.2):c.1072C&gt;T (p.(Pro358Ser)) and EGLN1 (NM_022051.2):c.1124A&gt;G (p.(Glu375Gly)) were identified as strong etiologic candidates.ConclusionCE is an extremely rare condition. Genetic testing is advised in young individuals with a long-standing persistent erythrocytosis, possibly with a family history and after exclusion of more frequent secondary causes and polycytemia vera.
Effect of BF839 + earthworm protein supplement on motor and some non-motor symptoms of Parkinson’s disease: a randomized clinical trial
Authors: Zeng Ting , Lin Chuhui , Deng Yuhong , Zhu Weiwen 
Published: September 2024

IntroductionSome studies have found that probiotics have the potential to treat PD, and earthworm protein is a traditional Chinese medicine used for the treatment of PD. The purpose of this study was to evaluate the safety and efficacy of Bacteroides fragilis 839 (BF839) + earthworm protein supplement as an adjunctive therapy for PD and to observe changes in the gut microbiota.MethodsForty-six patients with PD were recruited for a 12-week 1:1 randomized, double-blind, placebo-controlled clinical trial to evaluate changes in motor and some non-motor symptom scores and detect metagenomic changes in the gut microbiota.ResultsFrom baseline to 12 weeks, compared with placebo, the trial group showed significant reductions in the United Parkinson’s Disease Rate Scale (UPDRS) total score (−7.74 ± 5.92 vs. –1.83 ± 4.14, p &lt; 0.001), UPDRS part I (−0.72 ± 0.81 vs. –0.20 ± 0.72, p = 0.026), UPDRS part II (−2.50 ± 2.24 vs. –0.22 ± 1.98, p = 0.001), UPDRS part III (−3.43 ± 3.42 vs. –1.33 ± 2.65, p = 0.024), and UPDRS part IV (−1.13 ± 1.19 vs. –0.15 ± 0.57, p = 0.001). Significant reductions in the Hamilton Depression Scale-24 score (−3.91 ± 3.99 vs. +1.15 ± 3.42, p &lt; 0.001), Self-Rating Anxiety Scale scores (−7.04 ± 5.71 vs. –1.23 ± 2.34, p &lt; 0.001), and Constipation scoring system scores (−8.59 ± 4.75 vs. 0.27 ± 1.24, p &lt; 0.001), were also noted. In the trial group, one patient experienced mild eczema and one suffered low blood pressure, which could not be conclusively attributed to supplementation. Compared to the placebo group, the trial group showed a marked increase in Enterococcus faecium and a decrease in Klebsiella.ConclusionThis study is the first to report that probiotics plus earthworm protein can remarkably improve the motor and some non-motor symptoms of PD without serious adverse effects. However, further clinical trials and exploration of the underlying mechanisms are required.Clinical trial registrationClinical trial registry http://www.chictr.org.cn/, Identification No: ChiCTR2000035122.
Advances and trends in the application of functional near-infrared spectroscopy for pediatric assessments: a bibliometric analysis
Authors: Gao Lin , Lin Qianqi , Tian Dong , Zhu Siying , Tai Xiantao 
Published: September 2024

ObjectiveThe objective is to elucidate the collaboration and current research status in the pediatric field of fNIRS using bibliometric analysis, and to discuss future directions.MethodBibliometric analysis was conducted on publications related to pediatric fNIRS research published before June 2024 in the Web of Science Core Collection using VOSviewer software and R language.ResultsA total of 761 documents were retrieved, published by 2,686 authors from 893 institutions across 44 countries in 239 journals. The number of publications has significantly increased since 2012. The United States is the country with the highest number of publications, University College London is the institution with the most publications, Lloyd-Fox Sarah is the author with the most publications and significant influence, and “Neurophotonics” is the journal with the most publications. The current hotspots mainly involve using fNIRS to study executive functions and autism spectrum disorders in children.ConclusionThe study provides useful reference information for researchers by analyzing publication numbers, collaborative networks, publishing journals, and research hotspots. In the future, there should be an emphasis on enhancing interdisciplinary and international collaboration to collectively dedicate efforts toward the advancement of fNIRS technology and the standardization of research.
Exploring the use of bimodal transcranial direct current stimulation to enhance movement in individuals with patellofemoral pain—A sham-controlled double blinded pilot study
Authors: Ho Kai-Yu , Wallace Connan , Aquino Jeno , Broadwell Bryce , Whimple Makenzie , Liang Jing Nong 
Published: September 2024

IntroductionIn individuals with patellofemoral pain (PFP), addressing increased knee valgus during weight-bearing activities typically involves strengthening weak hip muscles. However, recent literature highlights the role of altered descending central control in abnormal movements associated with PFP. While transcranial direct current stimulation (tDCS) has demonstrated the capacity to enhance neuroplasticity, its application targeting the corticomotor function of gluteal muscles in PFP remains unexplored. This study aimed to investigate the effects of combining bimodal tDCS with exercise on frontal plane kinematics in individuals with PFP. The hypothesis was that bimodal tDCS, specifically targeting the corticomotor function of the gluteal muscles, would augment the effectiveness of exercise interventions in improving frontal plane kinematics compared to sham stimulation.MethodsTen participants with PFP participated in two sessions involving either bimodal tDCS or sham stimulation, concurrently with hip strengthening exercises. Weight-bearing tasks, including single leg squat, single leg landing, single leg hopping, forward step-down, and lateral step-down, were performed and recorded before and after each session. Pain visual analog scale (VAS) scores were also documented. A one-way ANOVA with repeated measures was employed to compare kinematics, while a Friedman test was used to compare VAS across the three conditions (pre-test, post-tDCS, and post-Sham).ResultsWe observed no significant differences in trunk lean angle, hip and knee frontal plane projection angles, or dynamic valgus index among the three conditions during the five weight-bearing tasks. VAS scores did not differ across the three conditions.Discussion and conclusionA single session of tDCS did not demonstrate immediate efficacy in enhancing frontal plane kinematics or relieving pain in individuals with PFP. Considering observed positive outcomes in other neurological and orthopedic populations with multi-session tDCS applications, suggesting potential cumulative effects, further research is essential to explore the effects of multi-session tDCS on weight-bearing movement and underlying neurophysiology in individuals with PFP.
Life course and mental health: a thematic and systematic review
Authors: Zhang Yuhu , Shaojun Chen , Akintunde Tosin Yinka , Okagbue Ekene Francis , Isangha Stanley Oloji , Musa Taha Hussein 
Published: September 2024

ObjectiveThis study explored the influence of the life course on mental health by identifying key trends, seminal works, and themes in existing research. Additionally, it highlights the major discussions at the intersection of life course and mental health.MethodsDocuments were extracted from the Web of Science Core Collection (WoSCC), to systematically analyze themes on mental health outcomes across the life course. The analysis was based on key bibliometric tools, including VOSviewer 1.6.11, R Studio software, and GraphPad Prism 9 to analyze the evolution and impact of scholarly contributions in this domain.ResultsThe accumulated body of research concerning the life course’s impact on mental health, which began to emerge around 1990 displayed a consistently upward trend. Predominant contributions originate from developed nations and frequently look into the psychosocial determinants of mental health over life course. Life course and mental health studies have been extensively infused with biopsychosocial frameworks that consider the role of genetic makeup, neurodevelopment, cognition, affect, sociocultural dynamics, and interpersonal relationships. Life course theory application in mental health highlight the substantive effects of accumulated adversities, notably social determinants of health, adverse childhood experiences (ACEs), and their implications for subsequent mental health outcomes.ConclusionThe nexus of life course and mental health outcomes demands further scholarly interrogation, particularly within underserved regions, to strengthen protective mechanisms for vulnerable populations.
The effects of mindfulness enhanced Tai Chi Chuan training on mental and physical health among beginners: a randomized controlled trial
Authors: Qu Ping , Zhu Xiaoqing , Zhou Hui , Kang Zhengyu , Li Ran , Wen Jingsi , Pan Feng , Liu Yang , Zhu Ting , Cao Qian , Wang Xiaoyan , Wang Yuyin 
Published: September 2024

IntroductionTai Chi Chuan (TCC) is a traditional Chinese mind–body exercise widely adopted in Chinese communities and colleges. However, the mindful essence of TCC is rarely emphasized during popularization. This makes it difficult for beginners to benefit from it. The present study aimed to examine the effects of a Mindfulness-enhanced Tai Chi Chuan (MTCC) intervention, which enhances mindfulness components embedded within TCC, on mental and physical health among beginners.MethodsA randomized controlled trial was conducted with 119 healthy college students new to Tai Chi Chuan training. Participants were assigned to either the MTCC group or the TCC group. Both interventions consisted of 10 weekly 90-min training sessions, with the MTCC group emphasizing and enhancing mindfulness components. Outcome measures included mindfulness, depression, anxiety, stress, and physical fitness, assessed at baseline and post-intervention.ResultsThe results showed that the MTCC group had significantly greater improvements than the TCC group in mindfulness, anxiety, stress, and health—and skill-related physical fitness. There were no significant differences between the two groups in depression.ConclusionThe findings suggest that compared to TCC, MTCC can effectively promote individuals’ physical fitness and provide additional benefits to mental well-being. MTCC can be recommended as an accessible and beneficial intervention for beginners to improve mental health and strengthen their bodies.Clinical review registrationhttps://www.chictr.org.cn/, identifier ChiCTR2200058175.
Religion, culture, and cancer: insights from a qualitative study on coping experiences of Filipino patients
Authors: Ahmadi Fereshteh , Zandi Saeid , Poblete Mae-Lanie 
Published: September 2024

IntroductionMeaning-making coping is used by people with cancer to help them deal with the stress and emotional turmoil associated with their diagnosis. It is a multifaceted approach that can be influenced by cultural, existential, and personal factors. Research on meaning-making coping among Filipinos diagnosed with cancer is sparse. This study examines how a sample of Filipino people with cancer cope with their illnesses.MethodsWe employed a qualitative approach. The study involved 20 participants with various types of cancer in the Philippines who were selected through purposive sampling and agreed to be interviewed.ResultsThe thematic analysis of the interviews revealed the application of both religious and secular meaning-making coping by participants. The study also confirmed the potential influence of culture on coping strategies.DiscussionThe results indicate that religion plays a significant role in Filipino coping mechanisms, given that the Philippines is predominantly a Christian nation. Additionally, the findings highlight the importance of close family ties in Filipino culture and how it contributes to coping with cancer.