bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana
Authors: Yeboah Kwame , Kyei-Baafour Eric , Antwi Daniel A. , Asare-Anane Henry , Gyan Ben , Amoah Albert G. B. 
Published: October 2016

Abstract
Background
Impaired angiogenesis is amongst the underlining mechanisms of organ damage in diabetes and hypertensive patients. In diabetes and hypertensive patients without proteinuria and overt CVDs, we studied the levels of angiogenic growth factors, angiopoietin (Ang)-1, Ang-2 and vascular endothelial growth factor (VEGF), and the relationship between these angiogenic growth factors and renal function, measured as estimated glomerular filtration rate (eGFR).

Method
In a case control design, 107 type 2 diabetes (T2DM) patients and 93 non-diabetes controls were recruited into the study. Levels of plasma glucose, lipids, creatinine and angiogenic growth factors; Ang-1, Ang-2 and VEGF measured from fasting blood samples. Estimated glomerular filtration rate (eGFR) was computed using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) algorithm and eGFR < 60 ml/min/1.73 m2 was considered to be low. Multivariable logistic regression was used to assess the odds of change in angiogenic growth factors among patients with diabetes and hypertension, and patients with low eGFR, compared to those without these conditions.

Results
In a total of 200 participants with 49 % females and mean age of 54.1 ± 10.2 years, 22.7 % of T2DM patients and 13.3 % of non-diabetes participant had low eGFR. The levels of Ang-1 and Ang-2 were highest in hypertensive T2DM patients, followed by patients with either T2DM or hypertension alone, with the controls having the lowest levels. The odds of change in circulating Ang-2 levels increased in patients with both diabetes and hypertension [11.76 (7.97–16.63), p < 0.01] compared to patients with either diabetes [5.45 (3.31–9.71), p = 0.02] or hypertension [5.45 (3.31–9.71), p = 0.02] alone. Compared to those with normal eGFR, the odds of change in serum Ang-2 levels were increased in patients with low eGFR in both the crude [1.26 (1.08–2.110), p = 0.023] and adjusted [1.14 (1.03–2.34), p = 0.043] regression models.

Conclusion
In our study population, having diabetes and hypertension increased the levels of Ang-1 and Ang-2. Also, low eGFR status was associated with increased levels of Ang-2 after adjustment for other risk factors.
Reconsidering Pye’s theory of making through digital craft practice: A theoretical framework towards continuous designing
Authors: Loh Paul , Burry Jane , Wagenfeld Malte 
Published: October 2016

Abstract
The term ‘Digital Craft’ is commonly applied in the context of craft as exercised with the aid of digital technology. If the application of digital tools and techniques merits the term digital craft, then where does the craft lie in Computer Numeric Control (CNC) making? This article takes the position that craft practice is rooted in the relationship between materials, tools and techniques as an intricate workflow. We suggest that the workflow can be considered as autopoietic in nature, in that it is both self-referential and self-making, at the same time as continuously designing. Through this, digital fabrication can be seen as a practice that co-evolves technology and material systems. The first author took a step back and reconsidered David Pye’s theory of making in relationship to digital craft practice. This is later cross-examined with a series of semi-structured interviews with contemporary craft practitioners, to devise a systematic approach to the analysis of craft practices. This research stems from the first author’s background in architecture, whose design practice is craft based using digital fabrication technology. Through this research, we examined making as a means of generating design knowledge in the process. The article suggests that the authenticity of craft lies within the deeper structure of the practice: the formation of repertoire where its social and cultural meaning is derived through coupling the practice with other systems.
Craft of inauthenticity: Notes on originality, media and craft exhibitions
Authors: Myzelev Alla 
Published: October 2016

Abstract
This position article argues that authenticity of craft objects hardly matters when we discuss the idea of crafts’ digital representation. Using three recent exhibitions as examples of representation of authenticity and craft in the digital realm the author demonstrates that, while the notions of identity, technique, material and the changes of the objects’ consumption continue to be important in audiences’ and scholars’ understanding of craft culture, the notion of the authentic has become irrelevant. The idea is that authenticity, when related to objects, is always a constructed notion located outside of the craft object. Given that, this article argues that in the era of constant change of the images through digital transformation, the notion of originality and its authenticity is less important while the path of transformation has gained significance.
On the horns of glocalization: A case study in the needlecraft industry – Coats Turkey
Authors: Soylu Yasemin , Er Özlem 
Published: October 2016

Abstract
This article summarizes the findings of a long-term marketing research project whose objective was to determine existing consumption patterns in the needlecrafts industry in Turkey. The research was carried out by one of the authors while working at Coats Turkey (CT), the world’s largest manufacturer and supplier of sewing and embroidery threads, as the Crafts Marketing Manager. A mini-case study of the company is therefore also included in the article. The main research questions addressed during the field study were ‘why and how do the thread consumers practice the needlecrafts?’ On the basis of the findings obtained from the long-term analysis of consumer attitudes, a consumer segmentation pattern has been proposed. The pattern has been revealed through interviews and face-to-face surveys, with more than 1000 embroidery teachers working at vocational high schools and public education centres and their students attending classes between 2000 and 2009 in Turkey. The pattern depicts the segmentation of motives for doing needlecrafts and suggests a distribution based on Maslow’s hierarchy of needs: as the socio-economical level of the consumer increases, the main motivation for doing needlecrafts stems from psychological rather than physical needs. Focusing more on the psychological needs of consumers, the company redesigned some of the experiences it offered to needlecraft consumers. Therefore, this article also elaborates on designing experiences for the needlecrafts industry and suggests that there may be opportunities for other crafts companies to implement such an approach, because as the competition gets intensive, product and service differentiation becomes more challenging and inadequate in terms of maintaining a sustainable business. Addressing psychological needs by means of designing experiences and focusing on experiential marketing seems to be one solution. Further research is needed to explore how other industries may benefit from focusing more on psychological needs by means of creating positive experiences.
Social Responses to Nature; Citizen Empowerment through Design
Authors: Phillips Robert , Brown Michael , Baurley Sharon 
Published: October 2016

Abstract
Traditionally, design content creation has remained within professional practice and manufacturing industries. Open Design (OD) utilizes accessible fabrication, enabling lay users to create and reappropriate content. Citizen Science encompasses activities where communities gather contextual environmental data for scientific or community purposes. The paradigm combination provides opportunities for communities, grass-roots projects and social initiatives with opportunities to create ‘products’ addressing personal and global issues. Social design (SD) combines OD/Citizen Science practices, empowering responses by fostering ‘innovations that are both good for society and enhance society’s capacity to act’. This article highlights a SD case study that applied OD/Citizen Science to beekeeping. The ‘Bee Lab’ project empowered participants to construct data-gathering devices, embodying Manzini’s SD approach. The case study aided motivated participants to address local/global issues, facing Apis mellifera (the honey bee). The project yielded insights into motivation, community leveraging, public engagement for social good and more. Insights have been distilled into repeatable stages for analogous activities. The results offer applications for communities, design agents or organizations wishing to address the burgeoning challenges facing social responses to nature.
Contemporary art by Chinese diaspora in a global age
Authors: Karetzky Patricia Eichenbaum 
Published: October 2016

Abstract
The art of overseas Chinese with its obvious connections with homeland culture is characteristic of the diaspora ethos. Traditional themes regularly appear: landscapes usually executed in traditional monochrome brush and ink, rock gardens, Chinese characters and calligraphy, historical references, and cultural emblems. In addition, it seems as though such artists are impelled to introduce the world to the merits of their heritage. Living among foreigners and experiencing western culture, new digital media, Internet access, freedom of expression, educational opportunities and global markets has broadened their perspective and their art. For this reason, their work does not look traditional: it makes use of new media, venues and forms of presentation and addresses a global rather than national arena. Although a wave of the most successful diaspora artists returned to China, they maintain a base of operation in the West and their art retains the characteristics they acquired living abroad.
Review
Authors: Conrad Harald 
Published: October 2016

Abstract
TŌKAIDŌ TEXTS AND TALES – TŌKAIDŌ GOJŪSAN TSUI, BY KUNIYOSHI, HIROSHIGE, AND KUNISADA, ANDREAS MARKS (ED.), LAURA ALLEN AND ANN WEHMEYER (2015) 1st ed., Gainesville: University of Florida Press, 216 pp., ISBN: 0813060214, h/bk, $80.00
Re-Enchantment in the Museum: Gaṇeśa, Hindu Art and the Living Divine
Authors: Pai Gita V. 
Published: October 2016

Abstract
Two statues of the elephant-headed Hindu god Gaṇeśa belong to the collections of San Francisco’s Asian Art Museum and New York’s Asia Society. These decommissioned temple idols from India were first displayed according to standard museological standards, but visitors began to make offerings and regard them with devotion. Considering the sculptures religiously, rather than artistically or historically, subverted the disciplined regimen of the museums’ spaces. In this article, I argue against Max Weber’s ‘disenchantment’ of the modern world that proposed a gulf between religious faith and scientific rationality. Instead, the example of these Gaṇeśa sculptures suggests a more intimate proximity between devotion and rationality in current instances of ‘museum re-enchantment’ by which visitors reclaim the spiritual significance of temple artefacts in museum contexts. In turn, curators have created strategies to maintain the conservation of artworks while accommodating practices of veneration.
Effect of exogenous IAA on tension wood formation by facilitating polar auxin transport and cellulose biosynthesis in hybrid poplar (Populus deltoids × Populus nigra) wood
Authors: Yu Min , Liu Kai , Liu Shengquan , Chen Haiyan , Zhou Liang , Liu Yamei 
Published: October 2016

Abstract
Auxins as phytohormons, responsible for coordination of growing processes, also contribute to the formation of tension wood (TW) in trees, but the mechanism of this process is still unclear. In this study, it has been tried to induce TW formation in erect hybrid poplar trees (in opposite to inclined or bended trees) by treatment with exogenous indole-3-acetic acid (IAA, as one of the auxins) or N-1-naphthylphthalamic acid (NPA) as an auxin transport inhibitor. The treatment with IAA resulted in TW formation and, as expected, NPA treatment did not. The gelatinous fiber formation and higher cellulose content in the cell wall were unambiguous indicators for TW formation. Real-time polymerase chain reaction (PCR) analysis revealed that genes of PIN1, ABCB1, and AUX2 involved in polar auxin transport were highly expressed in trees treated with exogenous IAA. Moreover, expressions of cellulose biosynthesis related genes of UGP1, UGP2 and CesA13 were strongly up-regulated. These observations indicate that the accelerated intercellular polar auxin transport caused by exogenous IAA is accounted for TW formation, i.e. the signal transduction of auxin is affected, which then facilitates cellulose biosynthesis. In contrast, the transcript abundances of PIN1 and all selected cellulose synthases (CesAs) were decreased after NPA treatment via inhibiting the cellular auxin efflux with negative effects on plant’s primary growth. These results are interpreted that TW formation is closely associated with the acceleration of intercellular polar auxin transport.
Estimation of Various Properties of CaO–“FeO”–SiO2 System at 1,673 K by Mass Triangle Model
Authors: Wang Yaxian , Wang Lijun , Chou Kuo-chih 
Published: October 2016

AbstractIn consideration of great need for the physicochemical properties of slag systems in metallurgical process estimation, this work examined the possibility of predicting multi-properties by one model. The mass triangle model was applied to evaluate the density, viscosity, surface tension and sulfide capacity of CaO–“FeO”–SiO2 system at 1,673 K. Good agreements were achieved between calculated data and experimental data in the various properties. Meanwhile, the calculated contour lines successfully predicted the properties of slag within the limited solubility area. The new model thus is competitive and flexible when an integrated knowledge of a certain system is necessary.
The Role of Vision and Auditory Distraction on the Temporal Congruence Between Physical Execution and Motor Imagery
Authors: Hohmann Tanja , Exner Martin , Schott Nadja 
Published: October 2016

Abstract
The study investigated the effect of vision and auditory distraction on the quality of motor imagery (MI). Sixty participants (M age 24.07 ± 3.64 years) completed the experimental task (modified version of Timed-Up-and-Go-Test (mTUG)) under three conditions: (A) baseline (no distraction), (B) positive and (C) negative auditory stimuli. Subjects were required to physically execute or imagine 10 series of the mTUG in each condition either with open/closed eyes. Results revealed better mental chronometry with open eyes whereas auditory distraction negatively affect performance. Findings imply that vision and auditory distraction should be taken into account as factors that influence MI quality.
Efficacy of growth hormone therapy in Kearns-Sayre syndrome: the KIGS experience
Authors: Quintos Jose Bernardo , Hodax Juanita K. , Gonzales-Ellis Bryn A. , Phornphutkul Chanika , Wajnrajch Michael P. , Boney Charlotte M. 
Published: October 2016

AbstractKearns-Sayre syndrome (KSS) is characterized by external ophthalmoplegia, retinal pigmentation and cardiac conduction defects due to mitochondrial DNA (mtDNA) deletions. Short stature and growth hormone (GH) deficiency have been reported in KSS, but data on GH treatment is limited. We describe the clinical presentation, phenotype evolution, and response to GH in a patient with KSS and report data on eight additional KSS patients from the KIGS database. Our patient with KSS and GH deficiency achieved a final adult height at −0.8 SDS. In the KIGS database GH treatment resulted in mean improvement in height from −3.9 to −2.9 SDS in patients with KSS. Two patients did not show growth improvement. Our data shows improvement in height SDS in our patient and mixed results in eight additional patients from the KIGS database after treatment with GH. Heterogeneity in responsiveness may relate to presence of GH deficiency or severity of underlying mitochondrial dysfunction.
Structure and bonding of 2,2,2-trichloroethylacetate: An experimental gas phase and computational study
Authors: Blomeyer Sebastian , Reuter Christian G. , Gil Diego M. , Tuttolomondo María E. , Altabef Aída Ben , Mitzel Norbert W. 
Published: October 2016

AbstractThe structural and conformational properties of 2,2,2-trichloroethylacetate, H3CCO2CH2CCl3, have been determined in the gas phase using gas electron diffraction (GED). The experimental measurements were complemented by MP2 and DFT quantum-chemical calculations. Two conformers separated by a shallow rotational barrier have been identified, one ofC1(syn-gauche) and the other ofCssymmetry (syn-anti). All calculations indicate thatsyn-gaucheis preferred in terms of enthalpy, whereassyn-antiseems to be slightly more stable regarding Gibbs free energy. In the gas-phase structure determination, dynamic models based on different potential energy surface scans were used. The one from dispersion-corrected density functional theory, predicting a preference ofsyn-gaucheby 1.7kJmol−1, was found to describe the experimental data best. One- and two-conformer models had to be rejected due to correlations and unrealistically large amplitudes. Experimentally determined structural parameters are in good agreement with both, quantum-chemical calculations as well as GED data for related compounds. Interacting quantum atoms (IQA) analyses revealed that interplay between the carbonyl group and the hydrogen as well as chlorine atoms of the trichloroethyl group accounts for most of the stabilisation of theC1conformer. With intramolecular symmetry-adapted perturbation theory (I-SAPT) analyses it was possible to further elucidate the nature of dominant interactions in the two conformers. Herein, preference ofsyn-gauchecan for the most part be attributed to electrostatic and to some extent to induction and dispersion interplays. In contrast this conformer is severely destabilised through steric repulsion. These results were supported by NBO analyses.
Synthesis, crystal structures and blue emission of zinc(II) halide complexes of 1-alkyl-imidazole and (–)-nicotine
Authors: Hobbollahi Elnaz , Veselkova Barbora , List Manuela , Redhammer Günther , Monkowius Uwe 
Published: October 2016

Abstract
Zn(II) halide complexes of the form L2ZnX2 (X=Cl, Br, I) containing bio-relevant or bio-related ligands like 1-alkyl-imidazoles (alkyl=methyl, ethyl and iso-propyl) or (–)-nicotine are presented. All complexes were characterized by 1H NMR spectroscopy, mass spectrometry and elemental analysis. The molecular structures of the majority of complexes were determined by single crystal X-ray diffraction. The zinc ion exists in a tetrahedral environment coordinated by two halide anions and two nitrogen atoms of the N-heterocycles. Upon photoexcitation the nicotine complexes feature a blue emission which we tentatively assign to phosphorescence.
One-Pot Synthesis of Cationic Gold Nanoparticles by Differential Reduction
Authors: Sperling Ralph A. , García-Fernández Lorena , Ojea-Jiménez Isaac , Piella Jordi , Bastús Neus G. , Puntes Víctor 
Published: October 2016

Abstract
The size-controlled synthesis of cationic particles by differential reduction of HAuCl4 precursor in the presence of NaBH4 and 1-aminoundecane-12-thiol (AUT) is reported. The number of seed particles is determined by the fraction of the initially Au precursor reduced by NaBH4 present in the reaction mixture, which are then grown larger by the AUT, acting as both weak reducing agent and stabilizing surfactant. By this methodology, size controlled synthesis is achieved in a two-step one-pot synthesis at room temperature.
Discovering Single Nucleotide Polymorphisms Regulating Human Gene Expression Using Allele Specific Expression from RNA-seq Data
Authors: Kang Eun Yong , Martin Lisa J , Mangul Serghei , Isvilanonda Warin , Zou Jennifer , Ben-David Eyal , Han Buhm , Lusis Aldons J , Shifman Sagiv , Eskin Eleazar 
Published: October 2016

AbstractThe study of the genetics of gene expression is of considerable importance to understanding the nature of common, complex diseases. The most widely applied approach to identifying relationships between genetic variation and gene expression is the expression quantitative trait loci (eQTL) approach. Here, we increased the computational power of eQTL with an alternative and complementary approach based on analyzing allele specific expression (ASE). We designed a novel analytical method to identify cis-acting regulatory variants based on genome sequencing and measurements of ASE from RNA-sequencing (RNA-seq) data. We evaluated the power and resolution of our method using simulated data. We then applied the method to map regulatory variants affecting gene expression in lymphoblastoid cell lines (LCLs) from 77 unrelated northern and western European individuals (CEU), which were part of the HapMap project. A total of 2309 SNPs were identified as being associated with ASE patterns. The SNPs associated with ASE were enriched within promoter regions and were significantly more likely to signal strong evidence for a regulatory role. Finally, among the candidate regulatory SNPs, we identified 108 SNPs that were previously associated with human immune diseases. With further improvements in quantifying ASE from RNA-seq, the application of our method to other datasets is expected to accelerate our understanding of the biological basis of common diseases.
ГИСТОХИМИЧЕСКАЯ ХАРАКТЕРИСТИКА ГИПОФИЗА КРУПНОГО РОГАТОГО СКОТА
Authors: Zaika S.S. 
Published: October 2016

Histochemical studies allowed to investigate the main aspects of the chemical statics and dynamics of the pituitary gland: location and nature of the reaction to the contents of nucleic acids, proteins, and lipids in cattle of different ages.It is installed the increased intensity of histochemical reactions to identify DNA and RNA. This indicates about the nucleic nature of the colloid, which is produced by the body and is a carrier of hormonal substances. The greatest concentration of nucleic acids was observed in the adenohypophysis of animals of 6 months of age. Here they are accumulated more in the adenocytes nuclei. The cells of a connective–tissue capsule of the pituitary gland have increased intensity of histochemical reactions to identify nucleic acids. Common proteins found in all histoststructure of the pituitary gland, but sometimes the preferential localization of the total protein in the pituitary gland of cattle in the age aspect is the anterior pituitary. The lipid in microstructures of the pituitary gland contained in all its parts. The intermediate fraction and the capsule of the pituitary gland are rich by them. Fat cells in the structures of the pituitary gland have not been identified because they usually are contained in the form of biocomplexity connections.The nature of the histochemical features of the pituitary gland of cattle depends on the age of the animals, and we studied the histochemical reactions of the colloid allow to characterize it as a mucopolysaccharide with impurities of proteins and a small amount of lipids.