bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of OSA on hypoxic and inflammatory markers during CPAP withdrawal: Further evidence from three randomized control trials
Authors: Turnbull Chris D. , Rossi Valentina A. , Santer Peter , Schwarz Esther I. , Stradling John R. , Petousi Nayia , Kohler Malcolm 
Published: November 2016

ABSTRACT
Background and objectiveObstructive sleep apnoea (OSA) is associated with cardiovascular disease. Intermittent hypoxia, endothelial dysfunction and adipose tissue‐mediated inflammation have all been linked to cardiovascular disease in OSA. We therefore explored the effect of OSA on relevant associated blood markers: adrenomedullin (ADM), endocan, endothelin‐1 (ET‐1), resistin and vascular endothelial growth factor (VEGF).MethodsPatients with OSA, established on and compliant with continuous positive airways pressure (CPAP) therapy for >1 year were included from three randomized controlled trials, conducted at two centres. Patients were randomized to either continued therapeutic CPAP or sham CPAP (CPAP withdrawal) for 2 weeks. Blood markers were measured at baseline and at 14 days and the treatment effect between sham CPAP and therapeutic CPAP was analysed.ResultsA total of 109 patients were studied (therapeutic CPAP n = 54, sham CPAP n = 55). Sham CPAP was associated with a return of OSA (between‐group difference in oxygen desaturation index (ODI) 36.0/h, 95% CI 29.9–42.2, P < 0.001). Sham CPAP was associated with a reduction in ADM levels at 14 days (−26.0 pg/mL, 95% CI −47.8 to −4.3, P = 0.02), compared to therapeutic CPAP. Return of OSA was not associated with changes in endocan, ET‐1, resistin or VEGF.ConclusionWhilst CPAP withdrawal was associated with return of OSA, it was associated with an unexpected significant reduction in the vasodilator ADM and not with expected increases in hypoxia‐induced markers, markers of endothelial function or resistin. We propose that the vascular effects occurring in OSA may be brought about by other mechanisms, perhaps partly through a reduction in ADM.
A Coverage Theory for Least Squares
Authors: Carè Algo , Garatti Simone , Campi Marco C. 
Published: November 2016

SummaryA sensible use of an estimation method requires that assessment criteria for the quality of the estimate be available. We present a coverage theory for the least squares estimate. By suitably modifying the empirical costs, one constructs statistics that are guaranteed to cover with known probability the cost associated with a next, still unseen, member of the population. All results of this paper are distribution free and can be applied to least squares problems in use across a variety of fields.
The Albian–Cenomanian transition and Oceanic Anoxic Event 1d – an example from the Boreal Realm
Authors: Bornemann André , Erbacher Jochen , Heldt Matthias , Kollaske Tina , Wilmsen Markus , Lübke Nathalie , Huck Stefan , Vollmar Nele M. , Wonik Thomas 
Published: November 2016

AbstractThe upper Albian to lower Cenomanian interval in the Hanover area (Germany) is characterized by a well‐developed lithological transition from upper Albian monotonous (marly) claystones of several hundred metres thickness, which become enriched in biosilica in the topmost Albian, to increasingly CaCO3‐rich marls and limestones in the lower and middle Cenomanian. This study presents a new 165 m thick composite record spanning the latest Albian to mid‐early Cenomanian (ca 103·0 to 97·5 Ma) based on two core drillings at Anderten in the central Lower Saxony Basin (east of Hanover), which is a sub‐basin of the North German Basin. Due to the lack or delayed occurrences of Tethyan biostratigraphic markers for the late Albian and early Cenomanian in the Boreal Realm, the definition of the Albian–Cenomanian boundary, as based on the lowest occurrence of Thalmanninella globotruncanoides, is not applicable. In order to overcome this issue, an integrated biostratigraphic–chemostratigraphic approach has been employed. In addition to biostratigraphy (calcareous nannofossils, ostracods, planktonic foraminifera and inoceramids), the Anderten succession has been studied using sedimentary geochemistry (CaCO3, total organic carbon, δ13C and δ18O), γ‐ray logging and X‐ray fluorescence core scanning. This approach enabled successful correlation of the composite Anderten record to European reference sections in England, south‐east France and Italy, as well as to further low‐resolution records from the Lower Saxony Basin (Wunstorf and Konrad 101 core). This work has made it possible to identify the δ13Ccarb expression of: (i) the Oceanic Anoxic Event 1d; (ii) the Albian–Cenomanian boundary interval; and (iii) potentially the Lower Cenomanian Event(s). Chemostratigraphic age assignments are supported by biostratigraphic results. Calcareous nannofossils indicate an extended Upper Cretaceous 0 (UC0) zone (upper Albian) up to Upper Cretaceous 2 (UC2; upper lower Cenomanian), and the occurrence of the ostracod Physocythere steghausi supports an early Cenomanian age for most of the upper part of the composite record. Notably, influxes of the planktonic foraminifer Thalmanninella aff. reicheli have previously been described from this area and the first appearance of this taxon is usually used to define the base of the middle Cenomanian Substage. However, findings from the Anderten cores and elsewhere suggest that this taxon has an apparently earlier first appearance, questioning previous age assignments from the Boreal Realm solely based on planktonic foraminifera. Due to both moderately well‐preserved microfossils and high sedimentation rates, the drilled succession of Anderten is considered as a potential Boreal reference section for the Albian–Cenomanian transition.
Red cell volume response to exercise training: Association with aging
Authors: Montero D. , Lundby C. 
Published: November 2016

Red blood cell volume (RBCV) is a main determinant of cardiorespiratory fitness in healthy individuals. However, it remains controversial to what extent exercise training (ExT) enhances RBCV. Therefore, we sought to systematically review and determine the effect of ExT on RBCV in healthy individuals across all ages. We conducted a systematic search of MEDLINE, Scopus, and Web of Science, since their inceptions until February 2016 for articles assessing the effect of ExT interventions (not including hypoxic training) on blood volumes in healthy individuals. A meta‐analysis was performed to determine the mean difference (MD) in RBCV between post‐ and pre‐ExT measurements. Thirty studies were included after systematic review, comprising a total of 299 healthy individuals (mean age = 19–71 years, 271 males). Exercise training programs primarily consisted in lower limb endurance training interventions (mean duration = 15.2 weeks). After data pooling, RBCV was not increased following ExT (MD = 49 mL, 95% CI = −11, 108; P = 0.11). In subgroup analyses, RBCV was increased after ExT in young and middle‐aged individuals (mean age <60 year) (n = 106, MD = 81 mL, 95% CI = 0, 162; P < 0.05) but not in older study participants (mean age ≥60 year) (n = 110, MD = 13 mL, 95% CI = −76, 102; P = 0.77). Heterogeneity was not detected among studies in young and middle‐aged (I2 = 0%) and older individuals (I2 = 0%). In conclusion, RBCV is moderately, yet consistently, enhanced by ExT in young and middle‐aged but not in older healthy individuals. Therefore, RBCV adaptations to ExT appear to be age dependent.
Patients' outcome after rescue plerixafor administration for autologous stem cell mobilization: a single‐center retrospective analysis
Authors: Spoerl Silvia , Peter Robert , Wäscher Dagmar , Götze Katharina , Verbeek Mareike , Peschel Christian , Krackhardt Angela M. 
Published: November 2016

BACKGROUNDPlerixafor is predominantly used for patients mobilizing inadequate stem cell numbers for autologous transplantation after stimulation with granulocyte–colony‐stimulating factor (G‐CSF).STUDY DESIGN AND METHODSWe here report on 300 patients undergoing stem cell mobilization with G‐CSF, among them 36 poor mobilizers (CD34+ cell counts < 50 × 106/L blood) receiving G‐CSF alone and 49 receiving G‐CSF in combination with plerixafor for rescue intervention. Mobilization efficacy and short‐time outcome after autologous stem cell transplantation were analyzed and compared in the respective subgroups.RESULTSOut of 49 patients treated with plerixafor and G‐CSF, 46 (94%) collected sufficient hematopoietic stem cell numbers although the number was clearly inferior in poor mobilizers. Compared to good mobilizers, viability of CD34+ cells analyzed after collection was slightly reduced in poor mobilizers independent of the application of plerixafor. A total of 232 patients underwent autologous stem cell transplantation, among them 26 poor mobilizers who received only G‐CSF and 31 patients who received G‐CSF in combination with plerixafor. Time until neutrophil engraftment was in median 1 day later in poor mobilizers irrespective of the application of plerixafor. Platelet engraftment was in median 2 days delayed in patients mobilized with G‐CSF and plerixafor compared to 1 day in poor mobilizers treated with G‐CSF only. Frequency of detected CD38+ CD138+ CD45– CD56+ plasma cells in the apheresis products of myeloma patients was comparable for all groups.CONCLUSIONOur data demonstrate that plerixafor is highly effective as rescue measurement after mobilization failure with G‐CSF alone and short‐term clinical outcome after stem cell transplantation is comparable.
ACOUSTICAL STANDARDS NEWS
Authors: Stremmel Neil B. , Struck Christopher J. 
Published: November 2016

American National Standards (ANSI Standards) developed by Accredited Standards Committees S1, S2, S3, S3/SC 1, and S12 in the areas of acoustics, mechanical vibration and shock, bioacoustics, animal bioacoustics, and noise, respectively, are published by the Acoustical Society of America (ASA). In addition to these standards, ASA publishes a catalog of Acoustical American National Standards. To receive a copy of the latest Standards catalog, please contact Neil Stremmel.
Comments are welcomed on all material in Acoustical Standards News.
This Acoustical Standards News section in JASA and other information on the Standards Program of the Acoustical Society of America are available via the ASA home page: http://acousticalsociety.org.
Complete Genome Sequences of Pseudomonas aeruginosa Phages vB_PaeP_PcyII-10_P3P1 and vB_PaeM_PcyII-10_PII10A
Authors: Pourcel Christine , Midoux Cédric , Latino Libera , Petit Marie-Agnès , Vergnaud Gilles 
Published: November 2016

ABSTRACT

vB_PaeP_PcyII-10_P3P1 and vB_PaeM_PcyII-10_PII10A are
Pseudomonas aeruginosa
bacteriophages belonging, respectively, to the
Lit1virus
genus of the
Podoviridae
family and the
Pbunavirus
genus of the
Myoviridae
family. Their genomes are 72,778 bp and 65,712 bp long, containing 94 and 93 predicted open reading frames, respectively.
Draft Genome Sequence of Lactobacillus plantarum Kanjika 2007, Isolated from Kanjika, a South Indian Traditional Food
Authors: Divyashri G. , Rajagopal K. , Prapulla S. G. 
Published: November 2016

ABSTRACT

The draft genome sequence of
Lactobacillus plantarum
Kanjika 2007, isolated from the South Indian staple, medicinal, and traditional food kanjika, is reported here. The whole genome consists of 3.16 Mb with a G+C content of 44.7% and 3,009 protein-coding genes, 78 tRNAs, and 4rRNAs (5S-23S-16S).
Complete Genome Sequence of the Siphoviral Bacteriophage Ec-ZZ2, Which Is Capable of Lysing Enterococcus faecium
Authors: Li Jinghua , Shi Hongyan , Zhao Chunyan , Hao Yuchong , He Yingze , Sun Yanbo 
Published: November 2016

ABSTRACT

A virulent bacteriophage (Ec-ZZ2) that infects
Enterococcus faecium
was isolated from sewage. The bacteriophage belongs to the family
Siphoviridae
and has a linear double-stranded DNA genome, with a length of 41,170 bp and a 34.59% G+C content, which is highly similar to
Enterococcus
phage IME-EF4.
Draft Genome Sequence for a Urinary Isolate of Nosocomiicoccus ampullae
Authors: Hilt Evann E. , Price Travis K. , Diebel Katherine , Putonti Catherine , Wolfe Alan J. 
Published: November 2016

ABSTRACT

A draft genome sequence for a urinary isolate of
Nosocomiicoccus ampullae
(UMB0853) was investigated. The size of the genome was 1,578,043 bp, with an observed G+C content of 36.1%. Annotation revealed 10 rRNA sequences, 40 tRNA genes, and 1,532 protein-coding sequences. Genome coverage was 727× and consisted of 32 contigs, with an
N
50
of 109,831 bp.
Complete Plastome Sequence of
Ludwigia octovalvis
(Onagraceae), a Globally Distributed Wetland Plant
Authors: Liu Shih-Hui , Edwards Christine , Hoch Peter C. , Raven Peter H. , Barber Janet C. 
Published: November 2016

ABSTRACT

Here, we present the first plastome of
Ludwigia octovalvis
(Onagraceae, Myrtales) as well as the first plastome in the subfamily Ludwigioideae. This genome is notable for its contracted inverted repeat regions and an expanded small single-copy region compared to other species in the orders Myrtales and Geraniales.
Draft Genome Sequence of Robinsoniella peoriensis 6600698, a Confounder of Clostridium difficile Diagnosis
Authors: Roberts Chrissy h. , Shaw Helen Alexandra , Ferguson Natalie , Holland Mark , Wren Brendan W. , Stabler Richard A. 
Published: November 2016

ABSTRACT

Robinsoniella peoriensis
is a Gram-positive, strictly anaerobic, spore-forming, rod-shaped organism. Here, we report the draft genome of
R. peoriensis
6600698, initially classified as
Clostridium difficile
due to growth on selective agar, a fecal
gdh
PCR-positive result, and clinical symptoms.
R. peoriensis
is a potential confounder of
C. difficile
diagnosis.
Genome Sequences of Three Species of
Hanseniaspora
Isolated from Spontaneous Wine Fermentations
Authors: Sternes Peter R. , Lee Danna , Kutyna Dariusz R. , Borneman Anthony R. 
Published: November 2016

ABSTRACT

Members of the genus
Hanseniaspora
represent a significant proportion of the normal flora of grape berries and play a significant role in wine fermentation. Here, we present genome sequences for three species of
Hanseniaspora
,
H. opuntiae
,
H. osmophila
, and
H. uvarum
, which were isolated from spontaneous Chardonnay wine fermentation.
Genome Sequences of Two Salmonella enterica Serovar Kentucky Isolates Recovered from Poultry Carcasses in the United States
Authors: Haley Bradd J. , Kim Seon Woo , Liljebjelke Karen , Guard Jean , Van Kessel Jo Ann S. 
Published: November 2016

ABSTRACT

We report here the draft genome sequences of two
Salmonella enterica
serovar Kentucky eBurstGroup 15 isolates collected from poultry carcasses in Georgia (USA).
Genome Sequence of an Acinetobacter baumannii Strain Carrying Three Acquired Carbapenemase Genes
Authors: Oinuma Ken-Ichi , Suzuki Masato , Sato Kanako , Nakaie Kiyotaka , Niki Makoto , Takizawa Etsuko , Niki Mamiko , Shibayama Keigo , Yamada Koichi , Kakeya Hiroshi , Kaneko Yukihiro 
Published: November 2016

ABSTRACT

The emergence of multiple-carbapenemase-producing
Acinetobacter
strains has been a serious concern during the past decade. Here, we report the draft genome sequence of an
Acinetobacter baumannii
strain isolated from a Japanese patient with three acquired carbapenemase genes:
bla
NDM-1
,
bla
TMB-1
, and
bla
OXA-58
.
Draft Genome Sequence of Marine-Derived Aeromonas caviae CHZ306, a Potential Chitinase Producer Strain
Authors: Cardozo Flávio Augusto , Zimpel Cristina Kraemer , Guimaraes Ana Marcia Sa , Pessoa Adalberto , Rivera Irma Nelly Gutierrez 
Published: November 2016

ABSTRACT

We report here a draft genome sequence of
Aeromonas caviae
CHZ306, a marine-derived bacterium with the ability to hydrolyze chitin and express high levels of chitinases. The assembly resulted in 65 scaffolds with approximately 4.78 Mb. Genomic analysis revealed different genes encoding chitin-degrading enzymes that can be used for chitin derivative production.
Interventions for paediatric surgery patients with comorbid autism spectrum disorder: a systematic literature review
Authors: Koski Scott , Gabriels Robin L , Beresford Carol 
Published: November 2016

AimsTo survey perioperative management practices for paediatric patients diagnosed with autism spectrum disorder (ASD).MethodsA systematic review was carried out of empirical studies and case reports published in peer-reviewed journals of current best practices and behavioural interventions for paediatric patients with ASD who had undergone surgery.ResultsThe final sample included 11 articles published between 1997 and 2016 that met broad inclusion criteria of surveying perioperative interventions for the ASD population. There is broad endorsement across the scant publications on this topic of the following practices: increased attention to individual patient needs, rehearsal and other desensitisation efforts, departure from a sole focus on sedation or restraint of the combative or uncooperative patient and engaging caregivers in tuning perioperative management to individual needs.ConclusionsThis review supports the need for an individualised structure and approach to the perioperative care of these unique patients.
Assessment of CardiOvascular Remodelling following Endovascular aortic repair through imaging and computation: the CORE prospective observational cohort study protocol
Authors: Nauta Foeke J H , Kamman Arnoud V , Ibrahim El-Sayed H , Agarwal Prachi P , Yang Bo , Kim Karen , Williams David M , van Herwaarden Joost A , Moll Frans L , Eagle Kim A , Trimarchi Santi , Patel Himanshu J , Figueroa C Alberto 
Published: November 2016

IntroductionThoracic aortic stent grafts are orders of magnitude stiffer than the native aorta. These devices have been associated with acute hypertension, elevated pulse pressure, cardiac remodelling and reduced coronary perfusion. However, a systematic assessment of such cardiovascular effects of thoracic endovascular aortic repair (TEVAR) is missing. TheCardiOvascularRemodelling followingEndovascular aortic repair (CORE) study aims to (1) quantify cardiovascular remodelling following TEVAR and compare echocardiography against MRI, the reference method; (2) validate computational modelling of cardiovascular haemodynamics following TEVAR using clinical measurements, and virtually assess the impact of more compliant stent grafts on cardiovascular haemodynamics; and (3) investigate diagnostic accuracy of ECG and serum biomarkers for cardiac remodelling compared to MRI.Methods and analysisThis is a prospective, nonrandomised, observational cohort study. We will use MRI, CT, echocardiography, intraluminal pressures, ECG, computational modelling and serum biomarkers to assess cardiovascular remodelling in two groups of patients with degenerative thoracic aneurysms or penetrating aortic ulcers: (1) patients managed with TEVAR and (2) control patients managed with medical therapy alone. Power analysis revealed a minimum total sample size of 20 patients (α=0.05, power=0.97) to observe significant left ventricular mass increase following TEVAR after 1 year. Consequently, we will include 12 patients in both groups. Advanced MRI sequences will be used to assess myocardial and aortic strain and distensibility, myocardial perfusion and aortic flow. ECG, echocardiography and serum biomarkers will be collected and compared against the imaging data. Computational models will be constructed from each patient imaging data, analysed and validated. All measurements will be collected at baseline (prior to TEVAR) and 1-year follow-up. The expected study period is 3 years.Ethics and disseminationThis study has been approved by the University of Michigan IRB. The results will be disseminated through scientific journals and conference presentations.Trial registration numberNCT02735720.
Prognostic factors of idiopathic inflammatory myopathies complicated with interstitial lung disease: protocol for a systematic review and meta-analysis
Authors: Kamiya Hiroyuki , Panlaqui Ogee Mer , Izumi Shinyu , Sozu Takashi 
Published: November 2016

IntroductionIdiopathic inflammatory myopathies may be an overlapping disease complex. Although interstitial lung disease affects the mortality and the morbidity of the disease, a clinical course and the prognosis of the disease complicated with interstitial lung disease are diverse among individuals and prognostic factors have yet to be clarified. This article aims to report the rationale and the methodology of a future intended systematic review and meta-analysis of prognostic factors of idiopathic inflammatory myopathies complicated with interstitial lung disease.Methods and analysisParticipants are eligible if they are diagnosed as polymyositis/dermatomyositis, clinically amyopathic dermatomyositis or antisynthetase syndrome complicated with interstitial lung disease. Primary outcomes are all-cause and pulmonary-cause mortality and secondary outcomes include a progression of the disease and a deterioration of health-related quality of life. All primary studies of any design aside from case reports or case series are included. 2 reviewers will search electronic databases such as the MEDLINE, the EMBASE and the Science Citation Index Expanded and extract relevant data independently. A risk of bias in individual studies is evaluated based on the Quality in Prognostic Studies tool. Meta-analysis will be conducted if 3 or more studies are available for each outcome and pooled effects will be presented by the odds ratio (OR). Where combining data is inappropriate due to a small number of studies or substantial heterogeneity, the result is reported qualitatively. Subgroup and sensitivity analysis are also considered based on clinical and methodological differences such as clinical manifestations, study designs and the quality of studies. The evidence level is assessed following the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) method.Ethics and disseminationThis study raises no ethical issues as it is based on the findings of previously published articles. The result will be reported in a peer-reviewed medical journal.Trial registration numberCRD42016036999.
Cohort study of growth patterns by gestational age in preterm infants developing morbidity
Authors: Klevebro S , Lundgren P , Hammar U , Smith L E , Bottai M , Domellöf M , Löfqvist C , Hallberg B , Hellström A 
Published: November 2016

ObjectivesTo examine differences in growth patterns in preterm infants developing major morbidities including retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), necrotising enterocolitis (NEC) and intraventricular haemorrhage (IVH).Study designCohort study of 2521 infants born at a gestational age (GA) of 23–30 weeks from 11 level III neonatal intensive care units in USA and Canada, and 3 Swedish population-based cohorts.OutcomesBirth weight and postnatal weight gain were examined relative to birth GA and ROP, BPD, NEC and IVH development.ResultsAmong infants with a birth GA of 25–30 weeks, birth weight SD score and postnatal weight were lower in those developing ROP and BPD. Infants developing ROP showed lower growth rates during postnatal weeks 7–9 in the 23–24 weeks GA group, during weeks 4–6 in the 25–26 weeks GA group and during weeks 1–5 in the 27–30 weeks GA group. Infants with BPD born at 27–30 weeks GA showed lower growth rates during postnatal weeks 3–5. Infants with NEC had lower growth rates after postnatal week 6 in all GA groups, with no significant differences in birth weight SD score. IVH was not associated with prenatal or postnatal growth.ConclusionsIn this cohort study of extremely preterm infants, we found that the postnatal growth pattern was associated with morbidities such as ROP, BPD and NEC as well as with gestational age at birth.