bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influencing factors on compliance of timely visits among patients with proliferative diabetic retinopathy in southern China: a qualitative study
Authors: Duan Fang , Liu Yuhong , Chen Xiang , Congdon Nathan , Zhang Jian , Chen Qianyun , Chen Lingling , Chen Xi , Zhang Xiulan , Yu Chengpu , Liu Yizhi 
Published: March 2017

ObjectiveTo identify the reasons for low adherence among patients with diabetic retinopathy (DR) in southern China using a qualitative method.MethodsExploratory indepth interviews were conducted in 27 diabetic patients with proliferative diabetic retinopathy who required vitrectomy surgery at Zhongshan Ophthalmic Centre, Sun Yat-sen University, from March to August 2015. Qualitative data analysis and research software (ATLAS.ti7) was used for data processing and analysis.ResultsFactors influencing the occurrence of timely visits included lack of DR related knowledge, fear and worries about insulin, interactions between patients and society combined with the complexity of emotions and social culture, and the economic burden of treatment.ConclusionsAlthough the reasons for low adherence involved social, emotional, cultural and economic factors, the key issue was the lack of awareness and knowledge of DR. Our findings have several practical implications for health policymakers and programme planners in China.
Improving swallowing outcomes in patients with head and neck cancer using a theory-based pretreatment swallowing intervention package: protocol for a randomised feasibility study
Authors: Govender Roganie , Smith Christina H , Gardner Benjamin , Barratt Helen , Taylor Stuart A 
Published: March 2017

IntroductionThe incidence of head and neck cancer (HNC) in the UK is rising, with an average of 31 people diagnosed daily. Patients affected by HNC suffer significant short-term and long-term post-treatment morbidity as a result of dysphagia, which affects daily functioning and quality of life (QOL). Pretreatment swallowing exercises may provide additional benefit over standard rehabilitation in managing dysphagia after primary HNC treatments, but uncertainty about their effectiveness persists. This study was preceded by an intervention development phase to produce an optimised swallowing intervention package (SIP). The aim of the current study is to assess the feasibility of this new intervention and research processes within a National Health Service (NHS) setting.Method and analysisA two-arm non-blinded randomised controlled feasibility study will be carried out at one tertiary referral NHS centre providing specialist services in HNC. Patients newly diagnosed with stage III and IV disease undergoing planned surgery and/or chemoradiation treatments will be eligible. The SIP will be delivered pre treatment, and a range of swallowing-related and QOL measures will be collected at baseline, 1, 3 and 6 months post-treatment. Outcomes will test the feasibility of a future randomised controlled trial (RCT), detailing rate of recruitment and patient acceptance to participation and randomisation. Salient information relating to protocol implementation will be collated and study material such as the case report form will be tested. A range of candidate outcome measures will be examined for suitability in a larger RCT.Ethics and disseminationEthical approval was obtained from an NHS Research Ethics Committee. Findings will be published open access in a peer-reviewed journal, and presented at relevant conferences and research meetings.Trial registration numberISRCTN40215425; Pre-results.
No effects of functional exercise therapy on walking biomechanics in patients with knee osteoarthritis: exploratory outcome analyses from a randomised trial
Authors: Henriksen Marius , Klokker Louise , Bartholdy Cecilie , Schjoedt-Jorgensen Tanja , Bandak Elisabeth , Bliddal Henning 
Published: March 2017

AimTo assess the effects of a functional and individualised exercise programme on gait biomechanics during walking in people with knee OA.MethodsSixty participants were randomised to 12 weeks of facility-based functional and individualised neuromuscular exercise therapy (ET), 3 sessions per week supervised by trained physical therapists, or a no attention control group (CG). Three-dimensional gait analyses were used, from which a comprehensive list of conventional gait variables were extracted (totally 52 kinematic, kinetic and spatiotemporal variables). According to the protocol, the analyses were based on the ‘Per-Protocol’ population (defined as participants following the protocol with complete and valid gait analyses). Analysis of covariance adjusting for the level at baseline was used to determine differences between groups (95% CIs) in the changes from baseline at follow-up.ResultsThe per-protocol population included 46 participants (24 ET/22 CG). There were no group differences in the analysed gait variables, except for a significant group difference in the second peak knee flexor moment and second peak vertical ground reaction force.ConclusionWhile plausible we have limited confidence in the findings due to multiple statistical tests and lack of biomechanical logics. Therefore we conclude that a 12-week supervised individualised neuromuscular exercise programme has no effects on gait biomechanics. Future studies should focus on exercise programmes specifically designed to alter gait patterns, or include other measures of mobility, such as walking on stairs or inclined surfaces.Trial registration numberClinicalTrials.gov:NCT01545258.
Adjunctive interpulmonary isthmus ablation has no added effects on atrial fibrillation recurrence
Authors: Higashiya Shunichi , Yamaji Hirosuke , Murakami Takashi , Hina Kazuyoshi , Kawamura Hiroshi , Murakami Masaaki , Kamikawa Shigeshi , Komatsubara Issei , Kusachi Shozo 
Published: March 2017

ObjectiveData on the efficacy of adjunctive interpulmonary isthmus ablation following completion of extensive encircling pulmonary vein isolation (EEPVI) on atrial fibrillation (AF) recurrence have still been insufficient. We aimed to compare the AF recurrence between EEPVI with and without adjunctive interpulmonary isthmus ablation.MethodsWe enrolled 200 consecutive patients with paroxysmal AF (first session) who underwent EEPVI with double-Lasso technique. Patients were prospectively randomised into two groups: EEPVI with (group 1) and without (group 2) adjunctive interpulmonary isthmus ablation.ResultsNo differences were found in patients’ clinical and echocardiographic backgrounds, including arrhythmia status, between the two groups. No differences were also observed in complications (two groin haematoma in both groups). All patients in both groups reached the EEPVI endpoint. The AF recurrence rate between groups 1 (32/100, 32%) and 2 (33/100, 33%; p=1.0) was quite similar during the follow-up period (45±5 months; 36–54 months). The two groups showed identical Kaplan-Meier AF-free curves (p=0.460; NS). Similar pulmonary vein (PV) reconnection incidence was observed in both groups during the second session. Durable isolation between the superior and inferior PVs was confirmed in 88% (21/27) of patients in group 1, indicating that interpulmonary isthmus ablation maintained a non-conducting state in a considerable number of patients. Nevertheless, AF recurrence was identical between the two groups.ConclusionThe results of our study showed similar AF recurrence rates between the two groups, indicating that adjunctive interpulmonary isthmus ablation with EEPVI has no obvious effects on AF recurrence.
Taxonomic review of Stictophaula (Orthoptera: Phaneropterinae) with the description of one new species from Brunei Darussalam
Authors: TAN MING KAI , WAHAB RODZAY BIN HAJI ABDUL 
Published: March 2017

Stictophaula Hebard, 1922 is a genus of katydid from the subfamily Phaneropterinae, and most similar to Arnobia Stål, 1876. A review of the genus Stictophaula reveals 26 species from Southeast Asia. One new species, Stictophaula bruneii sp. nov., is described from Brunei Darussalam. Nomenclature change is also verified: Arnobia ocellata comb. nov. An illustrated key to species is presented.
The experience of voice hearing and the role of self-help group: An interpretative phenomenological analysis
Authors: Rácz József , Kaló Zsuzsa , Kassai Szilvia , Kiss Márta , Pintér Judit Nóra 
Published: March 2017

Background: Auditory verbal hallucinations (AVHs) played an important role in the psychiatric diagnostics, but in the last few decades the diagnostic-free complex phenomenological understanding of the phenomena of voice hearing became the focus of studies. Materials: Six semi-structured interviews with recovering voice hearers were conducted and analysed using interpretative phenomenological analysis (IPA). Discussion: The self-help group gives significant help in identification and dealing with the voices; therefore, it serves as turning point in the life story of voice hearers. Conclusion: Applying self-help group in clinical context contributes to better outcomes in treatment of voice hearers.
Analysis of the Relationship between the Location of the Anterior Ethmoid Artery and Keros Classification
Authors: Poteet Perry S. , Cox Matthew D. , Wang Ran A. , Fitzgerald Ryan T. , Kanaan Alissa 
Published: March 2017

ObjectiveWe sought to identify a relationship between skull base height and anterior ethmoid artery (AEA) anatomy.Study DesignRetrospective radiologic chart review.SettingUniversity of Arkansas for Medical Sciences.SubjectsPatients seen in a tertiary rhinology clinic between September 2014 and October 2015.MethodsReview of 101 maxillofacial computed tomography scans with institutional review board approval. Skull base height and AEA locations were measured on each side. Prevalence of the AEA outside of the skull base and distance of the AEA from skull base were calculated and compared with Keros classification using χ2 testing. Comparisons of skull base height between sexes and age and distance between skull base and the AEA among Keros 2 and Keros 3 patients were made using an unpaired, 2‐tailed t test.ResultsThe AEA was located below the skull base in 25.7% of cases and more often in Keros type 3 (55%) than in Keros type 2 (29.5%) or Keros type 1 (0%) (P <. 05). Male patients were significantly more likely to have a greater average skull base height (5.25 vs 4.28 mm) and to have AEAs below the skull base (38.4% vs 14.8%). In addition, the distance of the AEA from the skull base was significantly higher in Keros type 3 patients compared with Keros type 2 patients (4.55 vs 3.42 mm, P =. 001).ConclusionsVariations in the AEA pathway occur more in male patients and those with higher Keros classifications. The distance between the variant AEA and the skull base increases with higher Keros classification. Keros classification can yield insight to the location of the AEA.
Diagnostic performance of breast ultrasonography and MRI in the prediction of lymph node status after neoadjuvant chemotherapy for breast cancer
Authors: Ha Su Min , Cha Joo Hee , Kim Hak Hee , Shin Hee Jung , Chae Eun Young , Choi Woo Jung 
Published: March 2017

Background Neoadjuvant chemotherapy (NAC) is widely used to treat breast cancer. Sentinel lymph node biopsy has replaced axillary lymph node dissection in patients who convert to node-negative status after NAC. However, few studies have evaluated the diagnostic performance of ultrasonography and magnetic resonance imaging (MRI) in determining axillary lymph node status after NAC. Purpose To evaluate the diagnostic performance of breast ultrasonography and MRI in determining residual metastatic axillary lymph node status after NAC for breast cancer and to identify histopathological factors affecting radiological performance. Material and Methods This study included 157 patients who underwent initial and follow-up preoperative breast ultrasonography and MRI before NAC between January and December 2010. The sensitivity, specificity, negative and positive predictive values, and accuracy of ultrasonography, MRI, and their combinations were evaluated. Results The sensitivity of ultrasonography, MRI, and their combination in post-NAC axillary imaging was 60.00%, 57.33%, and 65.33%, respectively; the specificity was 60.47%, 72.09%, and 60.47%, respectively. The positive predictive value was highest with MRI (78.18%). On univariate analysis, positive estrogen receptor status was associated with misdiagnosis by ultrasonography ( P = 0.002), MRI ( P = 0.002), and their combination ( P = 0.001). When residual metastatic lymph nodes were present, lymph nodes with macrometastasis (>2.0 mm) were associated with correct ultrasonography-based diagnosis ( P = 0.0027). Conclusion Imaging assists in predicting axillary lymph node status in patients undergoing NAC; however, is imprudent to omit sentinel lymph node biopsy or axillary lymph node dissection for staging in women determined to be node-positive.
Immunohistochemical evaluation of the activation of hepatic progenitor cells and their niche in feline lymphocytic cholangitis
Authors: Otte Corma MA , Valtolina Chiara , Vreman Sandra , Hubers Siobhan , van Wolferen Monique E , Favier Robert P , Rothuizen Jan , Penning Louis C 
Published: March 2017

Objectives The aim of the study was to compare the hepatic progenitor cell niche in healthy feline livers and the liver tissue of cats with lymphocytic cholangitis. Methods Immunohistochemical stainings for vimentin, laminin, beta (β)-catenin and Notch1 intracellular domain (NICD) were used on formalin-fixed liver biopsies from affected (n = 12) and unaffected cats (n = 2). Results All immunohistochemical markers used were expressed in more cells, or more intensely, in the liver tissue of cats with lymphocytic cholangitis than in the liver tissue of unaffected cats. Conclusions and relevance Enhanced expression of vimentin, laminin, cytoplasmic/nuclear β-catenin and NICD in liver biopsies from cats with lymphocytic cholangitis indicates that the hepatic progenitor cell (HPC) niche is remodelled and activated. HPCs might provide insights into new regenerative treatment options for lymphocytic cholangitis in cats in the future.
The evolution of publication hotspots in the field of telemedicine from 1962 to 2015 and differences among six countries
Authors: Wang Yanjun , Zhao Ye , Zheng Jianzhong , Zhang Ailian , Dong Haiyuan 
Published: March 2017

Introduction Telemedicine has been implemented in many countries and has captured the attention of many researchers. Herein, we aim to quantify publication hotspots in the field of telemedicine, analyse their evolution, compare them in different countries, and provide visual representations. Methods We used software tools to process PubMed entries for a 54-year period and identified publication hotspots using keyword frequency analysis. We employed a keyword co-occurrence analysis, principal component analysis, multidimensional scaling analysis, and network visualization technology. Results The number of Medical Subject Heading (MeSH) terms increased with time. The most common subcategories of telemedicine between 1962 and 2015 were Remote Consultation, Teleradiology, and Telepathology. The most popular information communication technologies in telemedicine publications were related to the Internet and cell phones. The topics of Patient Satisfaction, Treatment Outcomes, and Home Care Services associated with telemedicine were highlighted after the 1990s. Use frequency of the terms Cell Phones and Self-Care increased drastically in the past six years, and the publication focus in six countries that had the highest output was different. Knowledge network maps and perceptual maps show the relationship between high-frequency MeSH terms. Discussion The telemedicine field has experienced significant growth and expansion in knowledge and innovation in the last 54 years. Publication hotspots for telemedicine lean towards clinical treatment, home care services, and personal care, and countries emphasize publishing in areas related to their national characteristics. This study quantitatively discusses publication hotspots, provides an objective and systematic understanding of this field, and suggests directions for future telemedicine research.
Fine Particulate Matter and Total Mortality in Cancer Prevention Study Cohort Reanalysis
Authors: Enstrom James E. 
Published: March 2017

Background: In 1997 the US Environmental Protection Agency (EPA) established the National Ambient Air Quality Standard (NAAQS) for fine particulate matter (PM2.5), largely because of its positive relationship to total mortality in the 1982 American Cancer Society Cancer Prevention Study (CPS II) cohort. Subsequently, EPA has used this relationship as the primary justification for many costly regulations, most recently the Clean Power Plan. An independent analysis of the CPS II data was conducted in order to test the validity of this relationship. Methods: The original CPS II questionnaire data, including 1982 to 1988 mortality follow-up, were analyzed using Cox proportional hazards regression. Results were obtained for 292 277 participants in 85 counties with 1979-1983 EPA Inhalable Particulate Network PM2.5 measurements, as well as for 212 370 participants in the 50 counties used in the original 1995 analysis. Results: The 1982 to 1988 relative risk (RR) of death from all causes and 95% confidence interval adjusted for age, sex, race, education, and smoking status was 1.023 (0.997-1.049) for a 10 µg/m3 increase in PM2.5 in 85 counties and 1.025 (0.990-1.061) in the 50 original counties. The fully adjusted RR was null in the western and eastern portions of the United States, including in areas with somewhat higher PM2.5 levels, particularly 5 Ohio Valley states and California. Conclusion: No significant relationship between PM2.5 and total mortality in the CPS II cohort was found when the best available PM2.5 data were used. The original 1995 analysis found a positive relationship by selective use of CPS II and PM2.5 data. This independent analysis of underlying data raises serious doubts about the CPS II epidemiologic evidence supporting the PM2.5 NAAQS. These findings provide strong justification for further independent analysis of the CPS II data.
Factors associated with the achievement of mucosal healing in Crohn’s disease: the benefit of endoscopic monitoring in treating to target
Authors: Mao Ren , Qiu Yun , Chen Bai-Li , Zhang Sheng-Hong , Feng Rui , He Yao , Zeng Zhi- Rong , Ben-Horin Shomron , Chen Min-Hu 
Published: March 2017

Background: Mucosal healing (MH), the proposed treat to target in Crohn’s disease (CD), is associated with improved disease outcomes. There are still scant data on factors associated with achieving MH in clinical practice. We evaluated the probability of achieving MH and identified factors predictive of subsequent MH in patients with CD. Methods: This was a retrospective, observational cohort study. A total of 272 patients with CD with serial endoscopy assessment and subsequent therapeutic management were reviewed. The primary outcome was MH. The cumulative incidence of MH and endoscopic improvement was estimated using the Kaplan–Meier method. Factors independently associated with MH were identified using the Cox proportional hazards model. Results: Of the 272 patients, 126 (46.32%) achieved MH after a median follow-up period of 33 months (interquartile range: 27–38 months). Factors independently associated with MH by multivariate analysis were time between endoscopic procedures within 26 weeks (hazard ratio [HR]: 1.56; 95% confidence interval [CI]: 1.05–3.39), adjustment of medical therapy when MH was not achieved (HR: 2.07; 95% CI: 1.26–2.33), prior enteric fistula (HR: 0.22; 95% CI: 0.06–0.91), perianal disease at CD diagnosis (HR: 0.58; 95% CI: 0.35–0.95), and C-reactive protein normalization within 12 weeks (HR: 3.23; 95% CI: 1.82–5.88). Similar factors have also been identified for endoscopic improvement. Conclusions: Performing serial endoscopic procedures at a 26-week interval and subsequent adjustment in medical treatment are helpful in achieving MH. Endoscopic monitoring plays an important role in the treating to target of CD.
Effects of environmental change on population nutrition and health: A comprehensive framework with a focus on fruits and vegetables
Authors: Tuomisto Hanna L. , Scheelbeek Pauline F.D. , Chalabi Zaid , Green Rosemary , Smith Richard D. , Haines Andy , Dangour Alan D. 
Published: March 2017

Environmental changes are likely to affect agricultural production over the next 20–30 years. The interactions between environmental change, agricultural yields and crop quality, and the critical pathways to future diets and health outcomes remain largely undefined. There are currently no quantitative models to test the impact of multiple environmental changes on nutrition and health outcomes. Using an interdisciplinary approach, we developed a framework to link the multiple interactions between environmental change, agricultural productivity and crop quality, population-level food availability, dietary intake and health outcomes, with a specific focus on fruits and vegetables. The main components of the framework consist of: i) socio-economic and societal factors, ii) environmental change stressors, iii) interventions and policies, iv) food system activities, v) food and nutrition security, and vi) health and well-being outcomes. The framework, based on currently available evidence, provides an overview of the multidimensional and complex interactions between environmental change, diets and health, and forms the analytical baseline for future modelling and scenario testing. The framework identifies the inter-sectoral datasets and models that need to be defined and populated to assess the impacts of environmental change on agricultural production, food availability, nutrition and population health.
Extruded talus treated with reimplantation and primary tibiotalocalcaneal arthrodesis
Authors: Mohammad HR , A’Court J , Pillai A 
Published: March 2017

Extruded talus is a rare serious result from a high-energy injury to a supinated and plantar flexed foot. Treatment remains controversial with a lack of congruent evidence for talar reimplantation. A 34-year-old woman was involved in a road traffic accident at 40 mph. Imaging revealed a left talus extruded anterolaterally with a talar neck fracture. Additional injuries included right acetabular fracture, transverse process fractures and rib fractures, which were treated conservatively. The talus was reimplanted and the talar neck fixed with a cortical screw. A hindfoot nail was used to fuse the calcaneus, talus and tibia. Follow-up at two years showed solid tibiotalocalcaneal fusion, with no evidence of avascular development, and the patient was fully weight bearing without pain. We believe this is the first published case of successful primary tibiotalocalcaneal fusion for extruded talus injuries.
Análise temporal (2002-2014) da expansão da espécie de samambaia dicranopteris flexuosa no Vale do Pati (Brasil) utilizando técnicas de classificação de imagens de satélite
Authors: Leite Cândida Caroline Souza de Santana , Santos Sarah Moura Batista dos , Franca Washington De Jesus Sant’anna da , Vasconcelos Rodrigo Nogueira 
Published: March 2017

Afim de analisar as áreas ocupadas pela espécie de samambaia invasora Dicranopteris flexuosa no período entre 2002 e 2014, no Vale do Pati (Bahia-Brasil), foram utilizadas técnicas de classificação de imagens de satélite multiespectrais a partir dos algoritmos de classificação supervisionada Redes Neurais e Máxima Verossimilhança. Os resultados apontam que a espécie tende a se expandir rapidamente, impedindo a regeneração da flora nativa. O algoritmo que apresentou maior confiabilidade para tal foi o Redes Neurais. https://doi.org/10.14195/1647-7723_24_10