bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sistema pedagógico de gestión de la calidad (SPGC) en instituciones educativas
Authors: Martínez Valle Melisa Inmaculada , Sánchez Buitrago Jorge Oswaldo 
Published: September 2024

El interés de las Instituciones Educativas (IED) de básica y media por lograr un mejoramiento significativo en la calidad de sus procesos se ha convertido en un gran reto. Una de las estrategias en este sentido, ha sido la implementación de los Sistemas de Gestión de Calidad (SGC); los cuales se han convertido en una alternativa de planificación, sistematización, ejecución y seguimiento para las IED. Sin embargo, se observa que estos sistemas no siempre consultan las realidades institucionales, porque de manera reiterada se deja a un lado la esencia pedagógica de las IED; se desconoce, incluso, dando prevalencia a racionalidades empresariales y administrativistas propias de los sistemas de calidad; lo que evidencia el desplazamiento del Discurso Pedagógico (DP) por la preponderancia desmesurada del Discurso Administrativo (DA) en las prácticas de gestión asociadas a los SGC en las IED. La novedad en este libro es sustentar que cuando un SGC se reconfigura como un SPGC (SISTEMA PEDAGÓGICO DE GESTIÓN DE LA CALIDAD), responde de mejor forma a las particularidades de las IED y contribuye al mejoramiento de la calidad integral institucional, pensada también siempre desde y en función de la esencia pedagógica propia de tales instituciones; por eso su centralidad en el DP, desde el cual se puede dotar de nuevos sentidos, principios, significados y orientaciones a la praxis de gestión en las IED; aquí los SPGC se asumen e implementan como dispositivos pedagógicos para la mejor de la calidad educativa; este el reto que se asume al proponer un SPGC.
Bioelectronic Medicines-A Novel Approach of Therapeutics in Current Epoch
Authors: Kumar Ajay , Ashawat Mahendra Singh , Pandit Vinay , Kumar Pravin 
Published: September 2024

Background:
Bioelectronic medicines aim to diagnose and treat a wide range of illnesses and ailments,
including cancer, rheumatoid arthritis, inflammatory bowel disease, obesity, diabetes, asthma, paralysis,
blindness, bleeding, ischemia, organ transplantation, cardiovascular disease, and neurodegenerative diseases.
The focus of bioelectronic medicine is on electrical signaling of the nervous system. Understanding the nervous
system's regulatory roles and developing technologies that record, activate, or inhibit neural signaling to
influence particular biological pathways.

Objective:
Bioelectronic medicine is an emerging therapeutic option with the interconnection between molecular
medicine, neuroscience, and bioengineering. The creation of nerve stimulating devices that communicate
with both the central and peripheral nervous systems has the potential to completely transform how we treat disorders.
Although early clinical applications have been largely effective across entire nerves, the ultimate goal
is to create implantable, miniature closed-loop systems that can precisely identify and modulate individual
nerve fibers to treat a wide range of disorders.

Methodology:
The data bases such as PubMed, and Clinicaltrial.gov.in were searched for scientific research,
review and clinical trials on bioelectronic medicine.

Conclusion:
The field of bioelectronic medicine is trending at present. In recent years, researchers have extended
the field’s applications, undertaken promising clinical trials, and begun delivering therapies to patients,
thus creating the groundwork for significant future advancements. Countries and organizations must collaborate
across industries and regions to establish an atmosphere and guidelines that foster the advancement of the
field and the fulfillment of its prospective advantages.
Nanocarrier-Based Delivery Approaches of Mangiferin: An Updated Review on Leveraging Biopharmaceutical Characteristics of the Bioactive
Authors: Vishwakarma Km Khushboo , Hafeez Abdul , Usmani Shazia Afzal , Noor Layba , Khan Ishma Rahela 
Published: September 2024

Abstract:
In recent years, bioactive constituents from plants have been investigated as an
alternative to synthetic approaches of therapeutics. Mangiferin (MGF) is a xanthone glycoside
extracted from Mangifera indica and has shown numerous medicinal properties, such as
antimicrobial, anti-diarrhoeal, antiviral, anti-inflammatory, antihypertensive, anti-tumours,
and anti-diabetic effects. However, there are numerous challenges to its effective therapeutic
usage, including its low water solubility, limited absorption, and poor bioavailability. Nano
formulation approaches in recent years exhibited potential for the delivery of
phytoconstituents with key benefits of high entrapment, sustained release, enhanced solubility,
stability, improved pharmacokinetics, and site-specific drug delivery. Numerous techniques
have been employed for the fabrication of MGF-loaded Nano formulations, and each
technique has its advantages and limitations. The nanocarriers that have been employed to
fabricate MGF nanoformulations for various therapeutic purposes include; polymeric
nanoparticles, nanostructure, lipid carriers, polymeric micelles, Nano emulsions,
microemulsion & self-microemulsifying drug delivery system, solid lipid nanoparticles, gold
nanoparticles, carbon nanotubes, transfersomes, nanoliposomes, ethosomes & transethosomes,
and glycethosomes. Different biopharmaceutical characteristics (size, shape, entrapment
efficiency, zeta potential, in vitro drug release, ex vivo drug permeation,, and in vivo studies)
of the mentioned MGF-loaded nanocarriers have been methodically discussed. Patent reports
are also included to further strengthen the potential of MGF in the management of diseases.
The Effect of Erythromycin in Macrolide-Resistant Bordetella pertussis: Inhibitory Effect on Growth, Toxin Expression, and Virulence
Authors: Jiang Kaichong , Luan Yang , Wang Wei , Xue Da , Tang Shuyue , Peng Xiaokang , Liu Xiaoguai , Wang Zengguo 
Published: September 2024

Introduction:
The macrolide-resistant Bordetella pertussis (MRBp) has appeared in
Asia and has even been prevalent in China. Since the antibiotic sensitivity test is not carried out
in the clinical setting, macrolide is still the first choice of antibiotic in MRBp infection. Further,
the macrolide therapy for pertussis needs to be revised. Macrolide has always shown a positive
effect on other macrolide-resistant bacterium infections in clinical applications. However, the
mechanism of macrolide on MRBp remains unclear.

Objective:
The objective of this study was to investigate the effect of virulence of MRBp under
the sub-MIC erythromycin.

Methods:
This study evaluated a representative isolate BP19147 (ptxP1/fhaB3-MRBp) under a
series of sub-inhibitory concentrations of erythromycin. We measured the growth curve, biofilm
formation, and autoaggregation assay under Stainer and Scholte (SS) broth. The relative gene
expression was detected by RT-qPCR.

Results:
The proteomics was detected by label-fee DIA. The growth ability and virulence factors
of MR isolate BP19147 were inhibited by sub-MIC of erythromycin and had a concentration-
dependent effect. From the proteomics results, the pertussis toxin, filamentous haemagglutinin,
and pertactin did not show a statistical difference (p >0.05). Other virulence factors (including
dermonecrotic toxin, Invasive Adenylate cyclase/haemolysin. etc) showed a statistical
difference (p <0.05). In the KEGG enrichment, the BvgAS system, biofilm formation, and some
adaptive systems were inhibited by erythromycin.

Conclusion:
The sub-MIC of erythromycin may reduce the virulence of MRBp, which will provide
a theoretical basis for the rational use of erythromycin for MRBp infection and help the
development of new antibiotics.
Fascin Inhibitor NP-G2-044 Decreases Cell Metastasis and Increases Overall Survival of Mice-Bearing Lung Cancers
Authors: Zhang Zhi-hua , Liu Xin-yan , Feng Jun-peng , Li Li-fang , Li Xing-bing , Guo Su-min , Liu Li-hua , Wu Shu-cai 
Published: September 2024

Aim:
Fascin is an actin-binding protein that promotes tumor metastasis. The
inhibition of fascin on the progress of non-small cell lung cancer (NSCLC) is not very
clear. Hence, this study explored the potential effect of NP-G2-044, a novel fascin
inhibitor, in human NSCLC lines and the Lewis lung cancer (LCC) mice model.

Methods:
The growth of cells was analyzed via CCK-8 assays, and the flow cytometry
was adopted for cell cycle and apoptosis analysis, as well as the migration and
invasion of NSCLC cells with or without NP-G2-044. The therapy of NP-G2-044, which
synergizes with cisplatin and PD-1, was evaluated in the established xenograft Lewis’s
lung cancer of mice.

Results:
Fascin was overexpressed in human NSCLC cells, and inhibition of fascin by
NP-G2-044 attenuated NSCLC cell growth and remarkably undermined the ability of
migration and invasion in vitro, which was related to the reduced epithelialmesenchymal
transition (EMT) including downregulation of N-cadherin and vimentin,
and upregulation of E-cadherin. Further results implied that the above changes may be
partially mediated by the Wnt/β-catenin pathway. In vivo, NP-G2-044 slowed down
tumor development and enhanced overall survival alone, leading to synergistic anticancer
effects with cisplatin or PD-1 inhibitor.

Conclusion:
Fascin inhibition could inhibit the metastasis of NSCLC and has the
potential to enhance the efficacy of cisplatin and PD-1 inhibitors by blocking the Wnt/β-
catenin pathway.
Knowledge, Attitude, and Practices for Occurrence of Weight Gain Among the Night Shift Working Professionals in Maharashtra, India: A Cross-Sectional Survey
Authors: Medithi Srujana , Shapariya Prarthana , Muley Arti 
Published: September 2024

Introduction:
The biological clock or circadian rhythm of an organism is a set of regular
oscillations. Working at night or on night shifts disrupts the circadian rhythm. When the circadian
rhythm is disrupted, concentrations of adiponectin and leptin (satiety hormones) rise at night,
leading to overeating and fat gain, while lack of sleep elevates ghrelin levels of the hunger hormone.
Thus, the current study sought to explore the knowledge, attitudes, and practices about the
dietary and lifestyle factors amongst night-shift working professionals and to assess the influence
of knowledge and attitudes on their practices.

Methods:
A cross-sectional survey was conducted among individuals working night shifts in Maharashtra.
A pre-tested questionnaire consisting of questions related to their knowledge, diet, and
lifestyle was recorded and scored.

Results:
Among the 206 participants, a maximum of them were male (57.1%). Approximately
72.8% of respondents were quite young (25-30 years) and had been working the night shift for a
period of 9-12 months. The majority (76.6%) of respondents had no medical conditions. Many
(42.7%) of the night-shift working professionals were found to be obese. Significance was observed
between knowledge and attitude among the overweight BMI category.

Conclusion:
The participants had good knowledge in terms of dietary habits and lifestyle-related
factors. However, this was not reflected in their attitudes and practices. Therefore, interventional
research targeting attitudes and behaviors is required to improve behavioral patterns among overweight/
obese people.
Physicochemical Characterization and Antioxidant Activity of Algerian Bee Pollens: Exploring Geographical Influences
Authors: Djelloul Zidane 
Published: September 2024

Abstract:
This research study offers a comprehensive physicochemical analysis and assessment
of antioxidant activity for 15 bee pollen samples collected from diverse regions of Algeria. The
analysis included a wide range of parameters such as moisture content, sugar composition (fructose,
glucose, and sucrose), ash, electrical conductivity, free acidity, pH, total flavonoid (TFC)
and phenolic (TPC) contents, as well as protein and lipid contents. Additionally, the study evaluated
the antioxidant activity using two methods: DPPH radical scavenging activity and ferricreducing
antioxidant power (FRAP).The results revealed higher values of pH, free acidity, and
electrical conductivity, indicating potential variations in the physicochemical properties of bee
pollen samples from different regions. Notably, the samples were further distinguished by high
total phenolic content (26.23 mg GAE/g), flavonoid content (4.73 mg QE/g), and protein content
(21.7%), along with a unique mineral composition. The analysis also demonstrated the
highest total antioxidant capacity and a marked correlation with total phenolics. This study
highlights the influence of geographical factors on the physicochemical properties and antioxidant
activity of Algerian bee pollen. Regional variations underscore the importance of considering
geographical factors in evaluating bee pollen quality, nutritional value, and potential health
benefits of Algerian bee pollen. This emphasizes their crucial role in functional foods and natural
health products. Understanding these variations supplies valuable insights for optimizing the
utilization of bee pollen in functional foods, dietary supplements, and pharmaceutical formulations.
Further research into environmental factors influencing bee pollen's antioxidant properties
could enhance our understanding of its therapeutic potential.

other:
Further research into environmental factors influencing bee pollen's antioxidant properties could enhance our understanding of its therapeutic potential. Additionally, exploring the potential applications of Algerian bee pollen in functional foods, dietary supplements, and pharmaceutical formulations could provide opportunities for product development and innovation in the food and healthcare industries.
Hybrid Class Balancing Approach for Chemical Compound Toxicity Prediction
Authors: Santiago-Gonzalez Felipe , Martinez-Rodriguez Jose L. , García-Perez Carlos , Juárez-Saldivar Alfredo , Camacho-Cruz Hugo E. 
Published: September 2024

Introduction:
Computational methods are crucial for efficient and cost-effective drug
toxicity prediction. Unfortunately, the data used for prediction is often imbalanced, resulting in
biased models that favor the majority class. This paper proposes an approach to apply a hybrid
class balancing technique and evaluate its performance on computational models for toxicity
prediction in Tox21 datasets.

Methods:
The process begins by converting chemical compound data structures (SMILES
strings) from various bioassay datasets into molecular descriptors that can be processed by algorithms.
Subsequently, Undersampling and Oversampling techniques are applied in two different
schemes on the training data. In the first scheme (Individual), only one balancing technique
(Oversampling or Undersampling) is used. In the second scheme (Hybrid), the training data is
divided according to a ratio (e.g., 90-10), applying a different balancing technique to each proportion.
We considered eight resampling techniques (four Oversampling and four Undersampling),
six molecular descriptors (based on MACCS, ECFP, and Mordred), and five classification
models (KNN, MLP, RF, XGB and SVM) over 10 bioassay datasets to determine the
configurations that yield the best performance.

Results:
We defined three testing scenarios: without balancing techniques (baseline), Individual,
and Hybrid. We found that using the ENN technique in the MACCS-MLP combination resulted
in a 10.01% improvement in performance. The increase for ECFP6-2048 was 16.47% after incorporating
a combination of the SMOTE (10%) and RUS (90%) techniques. Meanwhile, using
the same combination of techniques, MORDRED-XGB showed the most significant increase in
performance, achieving a 22.62% improvement.

Conclusion:
Integrating any of the class balancing schemes resulted in a minimum of 10.01%
improvement in prediction performance compared to the best baseline configuration. In this
study, Undersampling techniques were more appropriate due to the significant overlap among
samples. By eliminating specific samples from the predominant class that are close to the minority
class, this overlap is greatly reduced.
Therapeutic Efficacy of Cannabis in the Management of Chronic Pain: An Opinion Paper
Authors: Polito Giacomo , Zovi Andrea , Coluccia Adriana , Vaccaro Marcello , Bagaglini Gabriele , Capuozzo Maurizio , Langella Roberto , Zavaleta-Monestel Esteban , Quesada-Villaseñor Ricardo , Ferrara Francesco 
Published: September 2024

Abstract:
In recent years there has been increased interest in exploring the therapeutic efficacy of
cannabis for the management of chronic pain among adult patients. However, the use of cannabis for
chronic pain is still a matter of debate and uncertainty. This opinion paper carried out a short overview
of the literature with the aim of evaluating data on efficacy and safety of cannabis-based medicines,
to fill the existing gaps in understanding the role of cannabis in therapy and to identify the critical
issues associated with their use. The analysis of existing literature has clearly highlighted the potential
benefits of cannabis-based preparations for the management of chronic pain. However, several criticalities
have been identified. These include the lack of standardization of preparations and the insufficient
clinical evidence to establish cannabis as the therapy of choice for chronic pain. As a result,
although the potential benefits of cannabis preparations for the management of chronic pain are clear,
further research is needed to address existing limitations and establish a solid scientific basis, especially
through real-world data collection.
TGF-β1 Induces Endoplasmic Reticulum Stress-Dependent Apoptosis in Human Placental Mesenchymal Stem Cells of Fetal Origin through PERK
Signaling Pathway
Authors: Zhu Yongzhao , Xue Wei , Na Juan , Huang Lijuan , Cai Ruizhi , Tao Jin , Ma Shuqin 
Published: September 2024

Background:
Mesenchymal Stem Cells (MSCs) are pivotal in immunomodulation, hematopoiesis,
and tissue repair. The interplay between MSCs and the pathological microenvironment
influences their proliferation and differentiation. Transforming Growth Factor-Beta 1 (TGF-
β1) serves as a key cytokine in the MSC microenvironment. This study aimed to scrutinize the
impact of TGF-β1 on human placenta-derived MSCs of fetal origin (fPMSCs) and elucidate its underlying
mechanism.

Methods:
fPMSCs were isolated, and surface markers were identified by flow cytometry. Cell proliferation
in fPMSCs was assessed using Cell Counting Kit-8 (CCK-8) and 5-Ethynyl-2’-Deoxy
Uridine (EdU). Apoptosis was detected via Annexin V/PI staining, and apoptosis-related proteins
were detected by western blot. Endoplasmic reticulum (ER) stress-related proteins were detected
by western blot, and Flou-4 AM staining was utilized to assess intracellular Ca2+ levels under
TGF-β1 exposure. The impact of 4-PBA treatment on ER stress and apoptosis was assessed by
western blot and Annexin V/PI staining. Additionally, the PERK and p-PERK expressions were
evaluated via Western blot.

Results:
CCK-8 and EdU assays revealed inhibited proliferation of fPMSCs under TGF-β1 exposure.
Annexin V/PI staining demonstrated a significant induction of apoptosis in fPMSCs following
TGF-β1 treatment. Furthermore, TGF-β1 treatment significantly elevated intracellular Ca2+ levels
and the expressions of GRP78, p-eIF2α, and CHOP. Interruption of ER stress with 4-PBA mitigated
TGF-β1-induced apoptosis in fPMSCs. Moreover, TGF-β1 increased p-PERK expression.
Inhibition of PERK autophosphorylation with GSK2606414 suppressed TGF-β1-induced apoptosis
and ER stress in fPMSCs.

Conclusion:
Our findings indicated that TGF-β1 induced ER stress-dependent apoptosis in fPMSCs
through the PERK signaling pathway. These results offer insights into enhancing the therapeutic
efficacy of fPMSCs by modulating TGF-β1-induced apoptosis.
Antibacterial Effect of Co-Loaded Curcumin and Rutin in Mesoporous Silica Nanoparticles Compared to their Loading Alone
Authors: Memar Mohammad Yousef , Yekani Mina , Sharifi Simin , Dizaj Solmaz Maleki 
Published: September 2024

Aims:
The present study aimed to assess the antibacterial effect of co-loaded rutin and curcumin in mesoporous silica nanoparticles (Cur-Rut-MSNs).

Background:
Rutin is a nontoxic phytochemical that is present expansively in vegetables and fruits. Curcumin is an active ingredient of Curcuma longa. Curcumin and rutin have a variety of thera-peutic effects, essentially antimicrobial, anti-inflammatory, and antioxidant actions.

Objective:
Low aqueous solubility and poor bioavailability of rutin and curcumin limit their appli-cation in therapeutic goals. One of the advantageous routes to improve their bioavailability and solubility is nanoformulation. Co-delivery of therapeutic agents has been reported to have better therapeutic effects than monotherapy.

Methods:
The present study has evaluated the antibacterial properties of Cur-Rut-MSNs. The Mini-mum Inhibitory Concentration (MIC) of Cur-Rut-MSNs has been assessed against different bacteria.

Results:
Cur-Rut-MSNs exerted significantly higher antibacterial effect than curcumin-loaded MSNs (Cur-MSNs) and rutin-loaded MSNs (Rut-MSNs) against Acinetobacter baumannii, Esche-richia coli, Staphylococcus aureus, and Enterococcus faecalis (p<0.05).

Conclusion:
The antibacterial effect was enhanced by the co-loading of rutin and curcumin in MSNs. According to the findings of this study, Cur-Rut-MSNs exhibit an antibacterial effect and can be a favorable nanoformulation against planktonic bacteria.
Interaction of High- and Low-Risk Human Papillomavirus Genotypes is
Associated with a Reduced Risk of Developing Cervical Cancer
Authors: Hasanzadeh Malihe , Rejali Marzieh , khalili-tanha ghazaleh , Mehramiz Mehraneh , Yavari Negar , Nazari Elham , malakuti Parnian , Maleki Faezeh , Ghorbannezhad Ghazale , Rafiei Mahdi , Mirani Anahita , Gholampoor-Shamkani Negar , Saber Hoda , mousavi seresht leila , Emamdadi‐Aliabad Zohreh , Mahdian Zahra , Akbari Mahdieh , Ferns Gordon A. , Al Moustafa Ala-Eddin , Avan Amir 
Published: September 2024

Introduction:
Cervical cancer is among the most common types of cancer in women and
is associated with human papillomavirus (HPV) infection. The association between cervical cancer
and high-risk HPV infection has been well documented. However, the effect of simultaneous infection with high- and low-risk HPV or low-risk HPV alone on the risk of developing cervical
malignancy remains unanswered in guidelines.

Method:
We investigated the association of high and low-risk HPVs (HR or LR) genotypes with
cervical carcinoma risk and pathological and cytological information in cases recruited from a population-based cohort study of 790 patients. Correlation matrix and t-test were used for analysis.

Results:
The percentage of HR+LR and HR-HPV16/18 were 9.30% and 11.20% in class II, 7.15%
and 7.10% in class IV, and 7.15% and 5.80% in As-CUS smears.
Interestingly, concurrent infection with HR-HPV and LR-HPV types led to a significant reduction
in the risk of developing malignancy compared to the high-risk group (OR=0.3 (0.098-0.925), pvalue=0.04). The percentage of individuals with cervical malignancy was 10.2% and 28.2% within
the co-infected and the HR-HPV participants.

Conclusion:
Our findings suggest that simultaneous infection with high- and low-risk HPV may
reduce the risk of cervical malignancy.