bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of imidacloprid on new queens of imported fire ants, Solenopsis invicta (Hymenoptera: Formicidae)
Authors: Wang Lei , Zeng Ling , Chen Jian 
Published: December 2015

AbstractNeonicotinoid insecticides are commonly used in managing pest insects, including the imported fire ant, Solenopsis invicta Buren. There is increasing evidence that neonicotinoid insecticides at sublethal concentrations have profound effects on social insects. However, the sublethal effect of neonicotinoids on S. invicta has never been investigated. In this study, the newly mated queens were fed with water containing 0.01 or 0.25 μg/ml imidacloprid. Imidacloprid at both concentrations did not cause any increase in queen mortality during the founding stage; however, it significantly reduced queens’ brood tending ability. In the 0.25 μg/ml imidacloprid treatment, the time to larval emergence was significantly delayed and no pupae or adult workers were produced. This study provides clear evidence that imidacloprid at sublethal concentrations has a significant detrimental impact on S. invicta queens and the development of incipient colonies.
Cell culture-derived HCV cannot infect synovial fibroblasts
Authors: Abd-Elshafy Dina N. , Pietschmann Thomas , Müller-Ladner Ulf , Neumann Elena , Anggakusuma  , Bahgat Mahmoud M. , Pessler Frank , Behrendt Patrick 
Published: December 2015

AbstractWorldwide 170 million individuals are infected with hepatitis C virus (HCV), up to 45 million of whom are affected by arthropathy. It is unclear whether this is due to viral infection of synovial cells or immune-mediated mechanisms. We tested the capacity of primary synovial fibroblasts to support HCV propagation. Out of the four critical HCV receptors, only CD81 was expressed to any significant extent in OASF and RASF. Consistent with this, pseudotyped HCV particles were unable to infect these cells. Permissiveness for HCV replication was investigated by transfecting cells with a subgenomic replicon of HCV encoding a luciferase reporter. OASF and RASF did not support replication of HCV, possibly due to low expression levels of miR-122. In conclusion, primary human synovial fibroblasts are unable to support propagation of HCV in vitro. HCV-related arthropathy is unlikely due to direct infection of these cells.
Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing
Authors: Chen Shixuan , Shi Junbin , Zhang Min , Chen Yinghua , Wang Xueer , Zhang Lei , Tian Zhihui , Yan Yuan , Li Qinglin , Zhong Wen , Xing Malcolm , Zhang Lu , Zhang Lin 
Published: December 2015

AbstractThe purpose of this study was to permit bone marrow mesenchymal stem cells (BMSCs) to reach their full potential in the treatment of chronic wounds. A biocompatible multifunctional crosslinker based temperature sensitive hydrogel was developed to deliver BMSCs, which improve the chronic inflammation microenvironments of wounds. A detailed in vitro investigation found that the hydrogel is suitable for BMSC encapsulation and can promote BMSC secretion of TGF-β1 and bFGF. In vivo, full-thickness skin defects were made on the backs of db/db mice to mimic diabetic ulcers. It was revealed that the hydrogel can inhibit pro-inflammatory M1 macrophage expression. After hydrogel association with BMSCs treated the wound, significantly greater wound contraction was observed in the hydrogel + BMSCs group. Histology and immunohistochemistry results confirmed that this treatment contributed to the rapid healing of diabetic skin wounds by promoting granulation tissue formation, angiogenesis, extracellular matrix secretion, wound contraction and re-epithelialization. These results show that a hydrogel laden with BMSCs may be a promising therapeutic strategy for the management of diabetic ulcers.
Knockdown of the partner protein OsNAR2.1 for high-affinity nitrate transport represses lateral root formation in a nitrate-dependent manner
Authors: Huang Shuangjie , Chen Si , Liang Zhihao , Zhang Chenming , Yan Ming , Chen Jingguang , Xu Guohua , Fan Xiaorong , Zhang Yali 
Published: December 2015

AbstractThe morphological plasticity of root systems is critical for plant survival and understanding the mechanisms underlying root adaptation to nitrogen (N) fluctuation is critical for sustainable agriculture; however, the molecular mechanism of N-dependent root growth in rice remains unclear. This study aimed to identify the role of the complementary high-affinity NO3− transport protein OsNAR2.1 in NO3−-regulated rice root growth. Comparisons with wild-type (WT) plants showed that knockdown of OsNAR2.1 inhibited lateral root (LR) formation under low NO3− concentrations, but not under low NH4+ concentrations. 15N-labelling NO3− supplies (provided at concentrations of 0–10 mM) demonstrated that (i) defects in LR formation in mutants subjected to low external NO3− concentrations resulted from impaired NO3− uptake and (ii) the mutants had significantly fewer LRs than the WT plants when root N contents were similar between genotypes. LR formation in osnar2.1 mutants was less sensitive to localised NO3− supply than LR formation in WT plants, suggesting that OsNAR2.1 may be involved in a NO3−-signalling pathway that controls LR formation. Knockdown of OsNAR2.1 inhibited LR formation by decreasing auxin transport from shoots to roots. Thus, OsNAR2.1 probably functions in both NO3− uptake and NO3−-signalling.
Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders
Authors: Frye M A , Nassan M , Jenkins G D , Kung S , Veldic M , Palmer B A , Feeder S E , Tye S J , Choi D S , Biernacka J M 
Published: December 2015

AbstractThe objective of this study was to determine whether proteomic profiling in serum samples can be utilized in identifying and differentiating mood disorders. A consecutive sample of patients with a confirmed diagnosis of unipolar (UPn=52) or bipolar depression (BP-In=46, BP-IIn=49) and controls (n=141) were recruited. A 7.5-ml blood sample was drawn for proteomic multiplex profiling of 320 proteins utilizing the Myriad RBM Discovery Multi-Analyte Profiling platform. After correcting for multiple testing and adjusting for covariates, growth differentiation factor 15 (GDF-15), hemopexin (HPX), hepsin (HPN), matrix metalloproteinase-7 (MMP-7), retinol-binding protein 4 (RBP-4) and transthyretin (TTR) all showed statistically significant differences among groups. In a series of threepost hocanalyses correcting for multiple testing, MMP-7 was significantly different in mood disorder (BP-I+BP-II+UP) vs controls, MMP-7, GDF-15, HPN were significantly different in bipolar cases (BP-I+BP-II) vs controls, and GDF-15, HPX, HPN, RBP-4 and TTR proteins were all significantly different in BP-I vs controls. Good diagnostic accuracy (ROC-AUC⩾0.8) was obtained most notably for GDF-15, RBP-4 and TTR when comparing BP-I vs controls. While based on a small sample not adjusted for medication state, this discovery sample with a conservative method of correction suggests feasibility in using proteomic panels to assist in identifying and distinguishing mood disorders, in particular bipolar I disorder. Replication studies for confirmation, consideration of state vs trait serial assays to delineate proteomic expression of bipolar depression vs previous mania, and utility studies to assess proteomic expression profiling as an advanced decision making tool or companion diagnostic are encouraged.
Balkan War of Apologies
Authors: Vuković Milica , Bratić Vesna 
Published: December 2015

After the war in ex-Yugoslavia subsided in the mid-90s, another war – this time a virtual one – broke out: the war of Balkan apologies. It refers to a decade-long series of apologies for participation in the conflict and the crimes committed during the war, as well as demanding the other parties to counter-apologise. The paper analyses all 19 apologies delivered by the top-ranking statesmen for their country’s/nation’s role in the conflict, which were delivered between 2000 and 2010. Their content is critically examined and wider social and political context is taken into account. The analysis points to the strengths and weaknesses of the apologies issued and dwells on their functions and the factors that have shaped them. The conclusion is that although the apologies are lacking in a number of ways, both contents-wise and regarding the manner they were delivered in, they might have been beneficial and could have had a role in reconciliating the ghosts of the past, present and future.
Synchronic requirements and diachronic permissions
Authors: Broome John 
Published: December 2015

AbstractReasoning is an activity of ours by which we come to satisfy synchronic requirements of rationality. However, reasoning itself is regulated by diachronic permissions of rationality. For each synchronic requirement there appears to be a corresponding diachronic permission, but the requirements and permissions are not related to each other in a systematic way. It is therefore a puzzle how reasoning according to permissions can systematically bring us to satisfy requirements.
Revisiting knowledge sharing from the organizational change perspective
Authors: Park Sunyoung , Kim Eun-Jee 
Published: December 2015

Purpose– The purpose of this study is to identify how knowledge sharing literature has discussed task, structure, technology and people as elements of organizational change and to examine the interactions between the four elements of knowledge sharing.Design/methodology/approach– The research questions guiding the study are: How do organizational change elements influence knowledge sharing? and What are the critical elements of organizational change in relation to knowledge sharing? Based on Leavitt’s (1965) organizational change model, 133 articles published between 2000 and 2012 from 13 journals were reviewed and analyzed.Findings– The total number of articles covering task, structure, technology and people in knowledge sharing was 49, 79, 49 and 97, respectively. Of all references, 97 articles (72 per cent) discussed the important aspects of people, and 79 articles (59 per cent) emphasized the influential role of organizational structure in knowledge sharing. The highest frequency of interactions (48 articles) was the interaction between structure and people (Interaction 5).Research limitations/implications– To capture broader phenomena on knowledge sharing in organizational change, multiple data sources and a variety of journals with a longer timeframe should be collected and a more comprehensive review should be conducted. All perspectives of organizational change were not applied to this study. Theoretically, this study attempted to illuminate how knowledge sharing has been explored through the lens of four elements in organizational change and the interactions between the elements. This study attempted to expand the use of Leavitt’s (1965) model by applying interactive relationships among the elements to knowledge sharing.Practical implications– The findings can advance strategic and managerial practice by informing the planning and development of knowledge sharing associated with change in organizations. A key question is how to identify the major component of change which will trigger the other changes in the current architecture of knowledge sharing in their organizations. This study suggests that elements of structure and people, when organization face either planned or unplanned change, are critical for successful knowledge sharing by making the interactive connections with other components of change.Originality/value– The contributions of this study are that it provides an integrative review in selected journals of knowledge sharing in terms of organizational change. By examining how knowledge sharing studies have addressed the four change factors and multi component changes, this study explains one change in knowledge sharing leads to multi-component changes. Additional contribution is that it makes connections between knowledge sharing and organizational change.
The Triple P – Positive Parenting Programme: the effectiveness of group Triple P and brief parent discussion group in school settings in Hong Kong
Authors: Chung Selina , Leung Cynthia , Sanders Matthew 
Published: December 2015

Purpose– The purpose of this paper is to evaluate and compare the effectiveness of two intervention formats of the Positive Parenting Programme (Triple P) – Level 4 Group Triple P (TP) and brief parent discussion group (DI) with the waitlist control group (WL).Design/methodology/approach– Participants included 91 Chinese parents with preschool children in Hong Kong from eight preschools, who were randomised into the two intervention conditions (TP and DI) and a waitlist control group (WL). Parent participants completed measures on child behaviours and parenting stress before and after intervention.Findings– Results indicated that there was a significant decrease in post-intervention child behavioural problems in the TP group, with a medium effect size when compared to the WL group. There was a decrease in post-intervention child behaviour problems in the DI group, compared with the WL group. No significant difference was found in post-intervention child behaviour problems between the TP group and the DI group.Practical implications– The positive results in the present study support the extension of the implementation of Triple P interventions to the preschool setting in Hong Kong. The effectiveness of the brief parent discussion group in reducing parental report of child behaviour problems provides preliminary support for its potential as a universal preventive parenting intervention in the local context.Originality/value– The study was the first evaluation of the Level-4 Triple P programme in a local school context as well as the first evaluation of effectiveness of the brief parent discussion group in the local context at the time of the study.
Putting your mind at ease: findings from the Mindfulness Ambassador Council programme in Toronto area schools
Authors: Smith-Carrier Tracy , Koffler Theo , Mishna Faye , Wallwork Anna , Daciuk Joanne , Zeger Jasmin 
Published: December 2015

Purpose
– The purpose of this paper is to gain understanding of the benefits and limitations of mindfulness training among secondary school students and teachers in Toronto, Ontario, Canada.

Design/methodology/approach
– Using a case study methodology, the authors analysed programme evaluation forms and conducted thematic analyses of focus groups with Catholic secondary school teachers and students that participated in the Mindfulness Ambassador Council programme.

Findings
– The findings suggest that mindfulness training may provide participants with opportunities for personal growth, specifically in the areas of stress reduction, relaxation, social awareness, self-discovery and relationship building.

Research limitations/implications
– This study confirms existing literature that training in mindfulness practice may be beneficial in strengthening relationships, reducing stress and anxiety and promoting inner well-being and social-emotional learning in youth. To test these findings empirically, future research should examine mindfulness training in schools using a robust randomised controlled trial design.

Practical implications
– Given the current state of research on mindfulness-based interventions specifically with the adolescent population, the study provides useful and timely data on participants
'
experiences with mindfulness training, and discusses how such training can be effectively harnessed within secondary school settings.

Originality/value
– There is growing evidence that the regular practice of mindfulness has myriad psychological, therapeutic and health benefits, and contributes to heightened emotional intelligence and improved performance in a host of activities. Relatively little is known, however, about the effects of mindfulness interventions on child and adolescent populations. The study contributes to the emerging evidence on mindfulness practice with students in school settings.
How standards and modularity can improve humanitarian supply chain responsiveness
Authors: Jahre Marianne , Fabbe-Costes Nathalie 
Published: December 2015

Purpose– The purpose of this paper is to increase understanding of the use of standards and modularity for improving responsiveness in the humanitarian context.Design/methodology/approach– Based on a conceptual framework and a systematic literature review, the authors conducted a longitudinal, explorative case on the Emergency Response Unit (ERU) concept in the International Federation of Red Cross Red Crescent Society (IFRC), focussing particularly on the Health ERU in the Norwegian Red Cross.Findings– The authors found that the ERU concept makes use of many types of standards that complement and influence each other, and that the focus on modularity is increasing due to a growing need for responsiveness. Main challenges are trade-offs between autonomy and adaptability to the context resulting in more modularization which may be in danger of breaking the concept.Research limitations/implications– Results from this study could be refined by surveying staff involved in all types of ERU deployments. To explore the generalizability of the findings and test the propositions developed, more studies should be conducted.Practical implications– The study provides more understanding of the use of standards and modularity for improving responsiveness. Practitioners can use the framework as a check-list to identify potential means for improvements. The case can be used for training, discussions, and reflections. The research feeds into IFRC’s and NORCROSS ongoing work to their global response tools.Social implications– The results of the study can support improvements in humanitarian supply chains, thereby providing affected people with cost-efficient, rapid, and better-adapted responses.Originality/value– The authors develop a framework for categorization of standards and modularity in the humanitarian context. The authors provide the first empirical study on how humanitarian organizations use standards and modularity to improve responsiveness concluding with a set of propositions on how the concepts are linked.
Hybrid simulation modeling for humanitarian relief chain coordination
Authors: Krejci Caroline C 
Published: December 2015

Purpose
– The purpose of this paper is to present a conceptual framework for a hybrid simulation model that can be used to study the decision making and behaviors of humanitarian logistics actors to determine how/whether certain coordination mechanisms enable better relief chain efficiency and effectiveness over time.

Design/methodology/approach
– The agent-based portion of the model is used to represent human decision making and interactions in a more realistic way than has been done previously, and the discrete-event simulation (DES) portion of the model allows the movement of vehicles, materials, and information throughout a supply network to be represented in a way that allows for dynamic and stochastic behavior.

Findings
– Coordinated efforts by actors in humanitarian logistics operations involve complex interactions and adaptations over time, which can be capture and explored via hybrid agent-based model (ABM)-DES modeling.

Research limitations/implications
– This paper describes a framework for a hybrid ABM-DES model. The actual development and implementation of the model, including input data collection and analysis, model development, experimentation, and output data collection and analysis, will be the subject of future work.

Practical implications
– The hybrid model framework provides other researchers with a starting point for model development.

Social implications
– This paper provides a basis for future modeling and assessment of coordination in humanitarian logistics, an area that is in need of research.

Originality/value
– The hybrid simulation modeling framework presented in this paper is a novel application of a new modeling methodology to the problem of coordination in humanitarian logistics.
Twenty years of the WTO Appellate Body’s “fragmentation jurisprudence”
Authors: Lang Andrew 
Published: December 2015

Purpose
– This paper aims to reflect on the first 20 years of the World Trade Organization (WTO) Appellate Body’s jurisprudence, specifically as it relates to questions of normative fragmentation. It provides an overview of some of the highlights of the WTO’s jurisprudence as it pertains to fragmentation, with particular focus on the use of general public international law in the context of the WTO dispute settlement.

Design/methodology/approach
– The paper adopts a traditional interpretive legal method, applied to the case law of the WTO.

Findings
– The paper suggests that the Appellate Body’s approach has not been driven by the institutional myopia and normative closure of which they are sometimes accused, but rather a judicial sensibility which (rightly or wrongly) valorises the virtues of modesty, caution and self-restraint.

Originality/value
– The paper contributes to the literature on the causes of fragmentation, drawing attention in particular to the importance of international lawyers and tribunals in contributing to fragmentation, not just responding to it. The fragmentation of international law is, in part, the product of ongoing boundary work, and the “fragmentation jurisprudence” of the Appellate Body has predictably involved boundary work of a particularly intense kind.
Changes in the jurisprudence of the WTO Appellate Body during the past twenty years
Authors: Roessler Frieder 
Published: December 2015

Purpose– This paper aims to examine changes in the jurisprudence of the World Trade Organization Appellate Body in three areas of law (judicial economy, the identification of the measure to be examined under Article XX of the General Agreement on Tariffs and Trade and other duties and import charges), and concludes that the Appellate Body failed to acknowledge and cogently explain in each of these areas, the changes it made.Design/methodology/approach– The paper asks two key questions: what has the Appellate Body done when its own rulings in past cases stood in the way of a legally sound ruling in a new case, and how should it handle such instances in the future?Findings– The paper concludes that all changes in jurisprudence reduce predictability, but that predictability suffers even more when the changes are made in disguise because panels and Members then receive confused or conflicting normative signals.Originality/value– The paper argues that the Appellate Body should seek consistency of jurisprudence wherever possible. It should handle changes in jurisprudence more transparently and adopt internal procedures that make the need for them less likely.