bluuebunny/crossref_metadata_2025_split huggingface dataset:
A qualitative study exploring participants experiences of the Mental Imagery for Suicidality in Students Trial
Authors: Duxbury Paula , Taylor Peter James , Palmier‐Claus Jasper , Boardman Bradley , Pratt Daniel , Parker Sophie , Lobban Fiona 
Published: September 2024

AbstractObjectivesHigher education students experience elevated levels of suicidal ideation, but often face barriers in accessing support. The Mental Imagery for Suicidality in Students Trial (MISST; ISRCTN13621293; NCT05296538) tested the feasibility and acceptability of a six‐session imagery‐based approach called Broad‐Minded Affective Coping (BMAC). This qualitative evaluation explored the experiences of MISST participants and staff.DesignA qualitative study using one‐to‐one qualitative interviews with participants and staff recruited from MISST. Reflexive thematic analysis was used to explore trial participant and staff experiences to inform a future definitive trial.MethodsStudent participants (n = 16), research assistants (n = 4) and the trial therapist (n = 1) were interviewed and transcripts analysed using reflexive thematic analysis.ResultsFour key themes were identified. The first theme highlights the value and challenges for students in talking about suicide. The ways in which communication and rapport can be built to facilitate this conversation are explored in theme 2. Theme 3 explains how working with the BMAC therapist increased participants’ awareness of their current mood, drew their attention to positive moments in their lives and helped them to actively recall these moments to interrupt negative cycles of rumination and suicidal ideation. The extent to which the BMAC is ‘fit for purpose’ is outlined in theme 4, generating specific recommendations for future intervention development.ConclusionsThe BMAC offers a positive, time‐limited, structured intervention that is well suited to meet the needs of higher education students experiencing suicidal ideation. Further research is needed to test the effectiveness on mental health and suicide‐related outcomes.
RETRACTED: Preliminary Evaluation of the Value of a Small‐Molecule Probe Targeting DNMT1 in Detecting the Methylation of PAX1 in Cervical Cancer
Authors: Yang Baohua , Cheng Qunxian , Hong Xiaoqian , Zhu Xiuxiang , Xia Ziyin , Chen Wei , Xu Ling 
Published: September 2024

ABSTRACTBackgroundTo investigate the screening value of a small‐molecule probe to assess the methylation of PAX1 in cervical cancer.Materials and MethodsThe diagnostic threshold of the grayscale values for cervical lesions was assessed by plotting the Receiver Operating Characteristic (ROC) curve of subjects. Grayscale values were significantly different among the four groups (p < 0.05). Compared with the LSIL and cervicitis groups, a considerably higher grayscale value was found in the CA and high‐grade squamous intraepithelial lesion (HSIL) groups (both p < 0.05).ResultsThe differential ROC curves of the grayscale values showed that the diagnostic Area Under Curve of the probe for cervicitis and low‐grade squamous intraepithelial lesion (LSIL) was 0.8724 (95% CI = 0.7762–0.9685, p < 0.0001), for cervicitis and CA was 1.0000 (p < 0.0001), for the LSIL and HSIL was 0.5484 (95% CI = 0.3826–0.7142, p = 0.5755), and for the LSIL and CA was 0.7724 (95% CI = 0.6016–0.9432, p = 0.0138).ConclusionThe small molecular probe has certain application value in differentiating the type of cervical lesions and has better efficacy in distinguishing cervical inflammatory and precancerous lesions from carcinogenesis, but less efficacy in determining the type of precancerous lesions.
The auronidin flavonoid pigments of the liverwort Marchantia polymorpha form polymers that modify cell wall properties
Authors: Jibran Rubina , Hill Stefan J. , Lampugnani Edwin R. , Hao Pengfei , Doblin Monika S. , Bacic Antony , Vaidya Alankar A. , O'Donoghue Erin M. , McGhie Tony K. , Albert Nick W. , Zhou Yanfei , Raymond Laura G. , Schwinn Kathy E. , Jordan Brian R. , Bowman John L. , Davies Kevin M. , Brummell David A. 
Published: September 2024

SUMMARYPlant adaptation from aquatic to terrestrial environments required modifications to cell wall structure and function to provide tolerance to new abiotic and biotic stressors. Here, we investigate the nature and function of red auronidin pigment accumulation in the cell wall of the liverwort Marchantia polymorpha. Transgenic plants with auronidin production either constitutive or absent were analysed for their cell wall properties, including fractionation of polysaccharide and phenolic components. While small amounts of auronidin and other flavonoids were loosely associated with the cell wall, the majority of the pigments were tightly associated, similar to what is observed in angiosperms for polyphenolics such as lignin. No evidence of covalent binding to a polysaccharide component was found: we propose auronidin is present in the wall as a physically entrapped large molecular weight polymer. The results suggested auronidin is a dual function molecule that can both screen excess light and increase wall strength, hydrophobicity and resistance to enzymatic degradation by pathogens. Thus, liverworts have expanded the core phenylpropanoid toolkit that was present in the ancestor of all land plants, to deliver a lineage‐specific solution to some of the environmental stresses faced from a terrestrial lifestyle.
Quantitative MRI for brain lesion diagnosis in dogs and cats: A comprehensive overview
Authors: Céré Cassandra , Curcio Valentina , Dorez Hugo , Debreuque Maud , Franconi Florence , Rousseau David 
Published: September 2024

AbstractMRI is widely used for the detection and characterization of brain lesions. There is a growing interest in the potential benefits of quantitative MRI (qMRI) in veterinary brain lesion diagnosis. Yet, the use of data processing tools in the veterinary field is not as democratized as for the diagnosis of human brain pathologies. Several reviews have addressed the characterization of brain lesions in cats and dogs. None of them is specifically focused on quantitative MRI data processing techniques for the diagnosis of brain lesions in the veterinary field. This paper aims to provide an overview of the evolution of qMRI on cats and dogs both in the clinical and preclinical fields. We analyze the achievements in the field as well as the remaining challenges in the diffusion of data processing tools for veterinary brain lesions characterization.
CT findings in a dog with chronic giant hypertrophic gastritis: Ménétrier‐like disease
Authors: Rifiova Jesika El , Schiborra Frederike , Mäntylä Noble Peter‐John , Vigevani Nina , Blundell Richard J. , Guillem James 
Published: September 2024

AbstractA 9‐year‐old male's entire Boston Terrier was presented with persistent hyporexia and weight loss for 6 weeks prior to referral admission. A CT scan showed marked hypertrophy of the rugal folds protruding into the gastric lumen, which had a cerebriform appearance. Changes were consistent with the ultrasonographic findings, which showed marked hyperechogenicity of the gastric mucosa, mucosal cysts, and otherwise normal wall layering. Histopathology of the fundic gastric mucosa showed foveolar hyperplasia and cystic dilation which were findings consistent with Ménétrier‐like disease. Based on the reviewed literature, this is the first case report describing CT findings of Ménétrier‐like disease in a dog.
Detection of Lubricating Film Breakdown in Mechanical Seals
Authors: Anderson William B. , Salant Richard F. , Jarzynski Jacek 
Published: September 2024

Abstract
Mechanical seals generally fail as the result of the collapse of the lubricating film between the two seal faces. A system to detect the collapse of the film before mechanical and thermal damage is sustained is being developed. The approach involves placing piezoelectric transducers behind the seal faces. One of the transducers is used as a receiver, while the other is used as a source. A continuous series of ultrasonic wave packets of a specified primary frequency and amplitude are generated by the source, using a wave generator. When the lubricating film collapses, mechanical contact between the two seal faces occurs, providing a transmission path for ultrasonic waves. The signal amplitude detected by the receiver therefore indicates whether or not mechanical contact between the seal faces has occurred. The advantage of this approach is it is relatively independent of the particular seal characteristics. Furthermore, since the amplitude and frequency of the signal generated by the source can be controlled, it can be distinguished from machinery noise.
Roller Bearing Defect Detection With Multiple Sensors
Authors: Billington S. A. , Li Y. , Kurfess T. R. , Liang S. Y. , Danyluk S. 
Published: September 2024

Abstract
Three levels of bearing outer race damage were tested over varying rotational speed and radial load. An acoustic emission sensor (AE) and accelerometer were used to record acoustic emission and vibration levels, respectively. The high frequency resonance technique (HFRT) and Adaptive Line Enhancer (ALE) were employed to process vibration signals. The primary metric of vibration level in this research is the Root-mean-square (RMS). The HFRT and ALE signal processing combination is effective in isolating deterministic defect frequencies. Finally a multi-layer perceptron neural network using accelerometer and AE RMS values was demonstrated as being successful in bearing defect level classification given operating conditions.
The Neural Network Identification of the Electro-Hydraulic Servo System
Authors: Hong He , Entao Zhou , Wei Sun , Shichang Zhou , Weixiang Shi , Tingqi Lin 
Published: September 2024

Abstract
A new kind of neural network based on RBFN and CMAC is proposed in this paper. The learning speed is very fast so that it can be used to identify the hydraulic servo system on line. A new model structure used for the identification of the hydraulic servo system with large alternating disturbance is also proposed in this paper. The simulation results are very satisfactory.
Adaptive Repetitive Control Design With Application to an Electrohydraulic Servo
Authors: Sun Zongxuan , Tsao Tsu-Chin 
Published: September 2024

Abstract
This paper addresses the discrete-time adaptive control design which incorporates internal model principle for asymptotic tracking performance of systems with parametric uncertainties, unmodeled dynamics and noise. The indirect adaptive control system applies projection or least squares parameter adaptation algorithm with dead zone, and frozen time stabilizing control. The global stability of the system is ensured under certain assumptions. The adaptive algorithm is applied to an electrohydraulic servo with periodic disturbances and reference trajectory. A frozen time stabilizing repetitive control is applied in parallel to the parameter adaptation algorithm. Experimental results show that the adaptive systems can tolerate parameter mismatch and unmodeled dynamics while maintaining stability and asymptotic tracking performance.
Experimental Validation of Pipeline Models for Laminar and Turbulent Transient Flow
Authors: Taylor Sue E. M. , Johnston D. Nigel , Longmore Derek K. 
Published: September 2024

Abstract
Work has been carried out on the time domain simulation of hydraulic pipelines. A new method of approximating frequency dependent friction has been developed (Sanada et al., 1993). The new optimised friction model has been incorporated into time domain simulation models. The results are validated by experimental tests. Transient test rigs have been designed for both laminar and turbulent flows. In both cases the levels of damping shown by the simulations corresponded favorably to the experimental results obtained.
A Modular Design Scheme for Servo-Drives Control, With Application to Pneumatic System
Authors: Refaat S. , Dransfield P. 
Published: September 2024

Abstract
A unified approach for control system design of single input-single output (SISO) mechatronic systems is presented. The approach is based on combining off-line identification, pole placement, composite adaptive control, sliding control, static nonlinearity compensation, gain scheduling, and plant on-line parameter estimation, each as a module. The approach is presented as modules added one after the other. Consequently, the effect of each of the modules and its integration with the other modules are demonstrated. The automation and plant-independence of these design steps are also shown. A nonlinear pneumatic long cylinder servo-system is used to test the approach experimentally. The approach is equally suitable for electric or hydraulic servo-drive technologies, in both position control and force control applications.
Fluid Power Systems in Downhole Seismic Exploration
Authors: Cole Jack H. 
Published: September 2024

Abstract
High-resolution subsurface seismic imaging that places sources and receivers in wellbores is an emerging exploration technology that can help petroleum companies find and recover more oil and gas. Success-commercialization of this enabling technology requires the development of stronger downhole seismic sources. New and larger downhole fluid power systems are playing a major role in such development. An extensive R&D effort has produced an electrohydraulic vertical shear wave source that is ready for commercial use. Research is continuing on other fluid power source concepts.
A Two-Compartment Membrane Limited Model of Molecular Transport Through Nano-Scale Pores With a Metal-Actuated Switch
Authors: Russo Michael J. , Friedman Simon H. , Karlsson Jens O. M. , Toner Mehmet 
Published: September 2024

Abstract
We have previously demonstrated that we can reversibly alter the transport selectivity of the plasma membrane to small molecules (∼1000 Da) by treating cells with H5, a genetic mutant of the pore-forming protein Staphylococcus aureus α-toxin, designed to be equipped with a metal-actuated switch. Toward the development of a plasma membrane permeabilization technique for both clinical and basic research applications, we have developed a simple model of molecular transport through the H5 pore. This model in combination with hindered transport models predicts the rate of transport of our marker molecules, carboxycalcein blue (CCB) and sucrose, and provides an approximation of the number of pores in the plasma membrane. Model predictions are also in reasonable agreement with experimental measurements of CCB and sucrose transport through the H5 treated plasma membranes of 3T3 fibroblasts. This model allows us to analyze quantitatively the selectivity of the H5 pore and by extension to use genetically designed pore forming proteins to advance the understanding of hindered transport in pores.
Changes in Osteoblasts Under Time Averaged Microgravity Conditions
Authors: Hung Clark T. , Johnston Eric D. , Allen Fred , Litt Mitchell , Pollack Solomon R. , Meaney David F. 
Published: September 2024

Abstract
Subtle alterations in mechanical stimuli can promote changes in mammalian cells ranging from cell realignment and intracellular signaling to immediate early gene expression. In this study, we examined the cellular growth and phenotypic activity of primary rat osteoblasts exposed to a simulated microgravity environment. We developed a method to produce time averaged microgravity conditions in tissue culture flasks and compared the response of cells in this environment to cells grown in conditions of unit gravity, both with and without hydrostatic pressure load. Three responses were measured after 6 days exposure to time averaged microgravity — degree of confluence, cell proliferation (assessed by DNA content (LaBarca and Paegan, 1980)), and normalized alkaline phosphatase (AP) activity, a marker of the cell phenotypic activity (Lowry et al., 1954).
Results show that time averaged microgravity conditions decrease the degree of cell confluence over stationary, unit gravity controls. Moreover, the cellular proliferation was increased in simulated microgravity conditions (n = 27 flasks/group; p &lt; .05). Interestingly, the normalized AP activity changed significantly under the simulated microgravity conditions examined in these tests, indicating that the phenotypic activity was modified under simulated microgravity conditions. Further tests with additional phenotype markers will augment these studies.
Together, this study begins a series of experiments for studying the effects of microgravity in primary cultured bone cells. The ultimate goal of these studies will be to elucidate the mechanisms responsible for cellular changes under microgravity, as well as determining the optimal conditions for cell and tissue growth in these conditions.
Engineered Substrates for Controlling Cell-Cell Interactions
Authors: Bhatia Sangeeta N. , Yarmush Martin L. , Toner Mehmet 
Published: September 2024

Abstract
Biomaterials have been previously engineered to serve a variety of different functions: precise degradation in vivo (Kimura, 1993), modulation of cell physiology via binding to specific ligands (Hubbell et al, 1992), and selective permeability of certain solutes (Lysaght et al, 1994). However, in complex tissues, where cell-cell interactions strongly influence tissue function, biomaterials which modulate this fundamental parameter have not been available. In this study, we describe a technique which allows control over cell-cell interactions by using semiconductor-based microfabrication, silane derivatization of borosilicate, and immobilization of specific biomolecules. We have focused on liver tissues due to the clinical significance of liver disease and the potential utility of a highly functional in vitro substitute for the liver (Rozga et al, 1994). Previous studies have reported that co-culture of primary hepatocytes with mesenchymal cells induces up-regulation of liver-specific functions in the hepatocyte population (Guguen-Guillouzo et al, 1983). Using microfabricated techniques to pattern co-cultures, we have demonstrated the importance of local cell-cell interactions in overall tissue function. Specifically, we show that the level of heterotypic interaction modulates the kinetics of up-regulation of liver-specific functions when compared to unpatterned controls. This approach will have applications in many areas including tissue engineering, developmental biology, and transplantation.
Determination of the Safe Touch Temperature for Various Surface Configurations and Materials
Authors: Subramanian Balakrishnan , Chato John C. 
Published: September 2024

Abstract
A finite difference heat transfer model has been developed to predict the Safe Touch Temperatures of objects with different material and geometric properties. The uncertainties in the physiological and thermal properties of human skin and tissue are accounted for by making conservative assumptions in the model. The damage function criteria developed by Henriques and Moritz are used to quantify thermal injury. The results indicate a strong dependence of Safe Touch Temperatures on the thickness dimension of the material, in addition to it’s thermal properties.
Finite-Element Codes to Model Electrical Heating and Non-Linear Thermal Transport in Biological Media
Authors: Humphries Stanley , Platt Robert C. , Ryan Thomas P. 
Published: September 2024

Abstract
ETherm is a versatile finite-element software system to model heating in biological media for electrosurgery and other medical applications. The electrical field component calculates penetration of RF radiation into conductive dielectrics. The thermal solver finds time-dependent or steady-state solutions using stable diffusion methods with automatic time step adjustment. An important feature is the capacity to treat non-linear diffusion with temperature-dependent thermal properties such as blood perfusion to represent physical changes of tissues. The program also evaluates Arrhenius damage integrals by maintaining temperature integrals over tissue elements.
Estimation of Blood Perfusion Using a Minimally Invasive Blood Perfusion Probe
Authors: Scott Elaine P. , Robinson Paul , Diller Thomas E. 
Published: September 2024

Abstract
This work is part of an ongoing research effort in which parameter estimation techniques have been utilized in the noninvasive measurement of blood perfusion using measurements from a new surface probe. The key element of the probe is a sensor which provides time-resolved signals representing heat flux and temperature. The probe incorporates a thin sensor, which is placed in contact with the tissue. For safety reasons no electric power or heating is applied to the probe; its low level signals are generated by the small temperature difference produced by air cooling. The probe is placed directly on the surface of the skin, and both temperature and heat flux are measured simultaneously at the surface while the probe is cooled by air jets. The small, light-weight probe can be taped to the skin, much like a surface electrode, for repeated measurements. A combination of analytical and experimental methods is being used for the development of the measurement system. A mathematical model of the probe and tissue during operation was developed previously to calculate temperature and heat flux at the surface of the skin. The design of the probe was first optimized using this model to maximize the sensitivity of the data for the determination of blood perfusion. Parameter estimation techniques were then developed to estimate blood perfusion and also the thermal contact resistance between the probe and the tissue. Here, both measured data and corresponding calculated data from the model are incorporated into an objective function which is minimized to simultaneously estimate the unknown properties. A probe of optimum design is being constructed and will be tested with appropriate phantoms. The final goal of this research is to develop a practical, noninvasive probe that will be clinically useful in the determination of blood perfusion.
Design, Analysis, and Optimization of Composite Leaf Springs for Light Vehicle Applications
Authors: Gratton Mathieu , Sancaktar Erol 
Published: September 2024

Abstract
Design and manufacture of a functional composite spring for a solar powered light vehicle is described. The objective is not to compare composite spring systems using different types of springs such as rubber disks, air shocks, etc., but to provide an understanding of the manufacture, use, and capabilities of composite leaf springs produced by using unidirectional E-glass roving impregnated by an epoxy resin for light vehicle applications where the vehicle weight is of primery concern. The current design application involves a solar powered car.