bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative study on energy efficient green building with conventional building
Authors: Mustafa Zakaria Ahmed Maryam , N Aravind 
Published: September 2024

Abstract
Green Building concept is an environmental building practice followed by the construction engineers since the years 2000s. Green building concept is the imperative of time with respect to economic, social and environment aspects. Green building techniques can mainly classify under six categories, waste management, water efficiency, energy efficiency, location, configuration and green materials, where under each technique countless solutions can be developed based on the requirements and the proposed project. Hence, this paper targets to redesign Barka Marina Mall, Oman as a green building considering building configuration, renewable energy and green materials, with the help of Building Information Modelling (BIM) technology and Photovoltaic System software as simulation tools. Aim of the present study is to redesign the Barka Marina Mall, Oman as a green building by considering the building configuration, renewable energy and green materials, with the help of BIM and Photovoltaic System software and compared the results with the conventional building. The criteria considered for the comparative analysis are, annual carbon emission, annual energy use, monthly fuel consumption and monthly energy consumption between the conventional and the green building. Based on the comparative study it is noticed that applying the green building concept has a great potential to save the nation’s resources and the environment by reducing the consumption as well as the cost.
Quantifying the Influence of Window-to-Wall Ratio (WWR) on Indoor Air Quality and Thermal Comfort: Classroom Study in Hot Arid Climates
Authors: Mostafa Hassieb Mai , Ragab Ayman , Farouk Mohamed Abdelaziz 
Published: September 2024

Abstract
Effective natural ventilation through well-designed windows plays a pivotal role in creating a healthy classroom environment, impacting students positively by ensuring fresh air, minimizing indoor pollutants, and maintaining comfortable temperatures. This study, conducted in educational buildings in Aswan, Egypt, investigates the influence of Window-to-Wall Ratio (WWR) on indoor air quality and thermal comfort. Utilizing the HOBO MX CO2 data logger and Design Builder simulation program, two models with WWRs of 20% and 30% were assessed. Results highlight the superiority of a 20% WWR, emphasizing the need to open windows for at least 60 minutes in the summer to achieve improved air quality and thermal comfort. The proposed enhancements, based on the findings, offer valuable insights into educational buildings in hot, arid regions.
Green campuses as pivots of sustainable development in Egypt
Authors: Ghalib Hebatullah 
Published: September 2024

Abstract
Sustainable development is a global aim to which Egypt is highly committed. This is evident in various projects and initiatives that aim to direct all activities towards more sustainable patterns and tools. Egyptian higher education institutions are an important partner and tool in enhancing sustainable development. University campuses, as the main anchors for higher education, take part in achieving this goal through developing green campuses that support the overall national sustainable development. This paper examines the presence of Egyptian universities in the global ranking of Green Campuses. It then focuses on two main case studies within the Egyptian context which are the AUC and ASU to compare their progress and identify their future priorities in Green Campus development.
Integrating Internet of Things and Big Data as an Approach for Enhancing the Quality of Life in Egyptian Cities
Authors: Elwazer Marwa N. , Ali Nessim Ashraf 
Published: September 2024

Abstract
In modern times, the concept of quality of life (QoL) has been a focal point in numerous studies, offering solutions to challenges faced by residents in new cities worldwide, including Egypt. To ensure citizens enjoy a high quality of life, cities are increasingly leveraging innovative technologies to address various aspects such as the environment, physical health, mobility, social interaction, psychological well-being, and the economy. Among these technologies, the Internet of Things (IoT) plays a significant role in enhancing people’s lives. By utilizing IoT as an information technology tool, cities can tackle their unique challenges. Consequently, the IoT method and the information obtained through Big Data (BD) analysis will enhance cities sustainability, safety, and liveability for residents. This research aims to explore the integration of IoT and BD for enhancing the quality of life in Egyptian cities. A qualitative methodology is employed to achieve this goal. Initially, a comprehensive literature review is conducted to uncover the relationship between improving quality of life in Egyptian cities and the use of IoT and BD methods. Additionally, a case study of Busan city, which has successfully implemented several IoT technologies to enhance the well-being of its inhabitants, is presented and analyzed. The findings from both the literature review and the case study highlight the positive correlation between the adoption of IoT and BD technologies and the overall quality of life in cities, spanning dimensions such as transportation, economy, social aspects, and the environment.
Integrating Real Estate Investment Environment Indicators with Sustainable Urban Development: An Evaluation Framework for Egyptian new cities
Authors: Chaarawi Z. , Elbarmelgy M. 
Published: September 2024

Abstract
The decision-making process in real estate investment is strongly linked with economic development and the real estate market, exerting a significant influence on the construction industry. In Egypt, decision-makers often prioritize responding to investment pressures to attract investors and establish projects, neglecting the alignment of investments with the principles of sustainable urban development. This study aims to identify the indicators of real estate investment environment according to the sustainable urban development, enhancing the decision-making process in the urban development of new Egyptian cities. Additionally, the research seeks to show best practices and successful global initiatives that effectively integrate real estate investment environment with sustainable urban development, emphasizing on innovative strategies and policies. The study will conclude indicators that harmonize economic progress with spatial, environmental, and social sustainability to enhance decision-making processes in urban development by adopting a more holistic and inclusive approach.
Planners as Gatekeepers: Spatial Justice Through the lens of Planning Theory in Helsinki
Authors: Hewidy H. 
Published: September 2024

Abstract
Planning practice is a device of controlling land use and ideally corresponds to societal demands. It can contribute to spatial justice through its two roles, substantive and procedural. Planning theory, on the other hand, studies both roles of planning practice focusing on the interplay of power. Helsinki witnesses a rapid and dynamic urban growth with the Finnish capital city plan adopting bold ideas aiming to create pedestrian friendly urban centers further from the inner city. Among other objectives, the city plan employs anti-segregation policy in certain areas. Ethnic retail has been emerging in Helsinki at several locations not only fulfilling socio-economic needs of immigrants but also enhancing public street life and creating urban hubs. In particular, ethnic retail is clustered at two strip malls located in two neighborhoods under urban renewal. Two competitions were organized to guide the land-use based on the objectives of the city plan. This article studies how urban planning policy and planners have steered the urban renewal outcome. The findings show that the planners can serve as gatekeepers allowing specific outcomes in favor of certain actors. The article contributes to literature analyzing planning practice through the theory lens.
Investigating the Role of Change Management in Achieving Sustainable Project Management in Construction Firms
Authors: Ahmed K N , Khodeir L M , Gadelhak M 
Published: September 2024

Abstract
Over the past years, the construction sector has seen significant transformation driven by sustainability and change management, as most construction companies strive to lower emissions, be future-proof, and slow down the rate of climate change. While these two disciplines have distinct goals, they share essential principles. Both change management and sustainable project management emphasize addressing the environmental, social, and economic aspects while maintaining ethics, transparency, and stakeholder demands. According to previous studies, incorporating sustainability concepts into project management systems could enhance organizational value, risk control, cost savings, stakeholders’ relationships, and long-term value generation. In the context of change management, integrating sustainability into project management systems strives to ensure that initiatives are not only financially feasible but also socially and ecologically responsible. Despite previous research in those fields, further investigation and application of the implementation methodologies are still recommended. The main aim of this paper is to investigate the relationship between sustainability in the project management field, its relation to change management procedures, and how it could be beneficial for the implementation process in the construction industry. A constructive literature review was adapted to develop a potential primary framework for future implementation, which facilitates future attempts at construction organization implementation processes.
A comparison between CAD system and building information modelling (BIM)
Authors: Mamdouh M , Moursy O , Hassan AA , Gerges VF 
Published: September 2024

Abstract
Building Information Modeling (BIM) has gained widespread recognition as a collaboration process in the construction industry, leading to increased investment by construction companies across all construction stages. in recent years, engineers and project managers have encountered various challenges. These challenges include communication gaps among stakeholders and decision-makers, frequent design changes during implementation resulting in repetitive work, increased project costs, delays, and compromised project quality. This research proposes a methodology that compares BIM technology with traditional CAD methods by applying both systems to the same project. It aims to highlight the problems associated with the traditional system and demonstrate how BIM resolves them. Clash detection, for instance, addresses implementation issues and reduces the need for rework. Studies have shown that BIM significantly reduces errors and omissions in documents by up to 64%, repetitive work by up to 43%, project costs and project duration. Considering these advantages, it is highly recommended to incorporate Building Information Modeling (BIM) technology in all construction projects.
Directed protein engineering identifies a human TIM-4 blocking antibody that enhances anti-tumor response to checkpoint inhibition in murine colon carcinoma
Authors: Frietze Karla K , Anumukonda Kamala , Padula Laura , Strbo Natasha , Goldstein Neil 
Published: September 2024

Abstract

Background
T-cell immunoglobulin and mucin domain containing molecule-4 (TIM-4) is a scavenger receptor best known for its role in recognizing dying cells. TIM-4 orchestrates phagocytosis allowing for cellular clearance of apoptotic cells, termed efferocytosis. It was previously shown that TIM-4 directly interacts with AMPKα1, activating the autophagy pathway, leading to degradation of ingested tumors, and effectively reducing antigen presentation.

Methods
This study sought to identify a novel human TIM-4 antibody that can prevent phagocytosis of tumor cells thereby allowing for more antigen presentation resulting in anti-tumor immunological response. Using phage display panning directed against human TIM-4, we engineered a novel human TIM-4 antibody (SKWX301). Combination of in vitro phagocytosis assays and cell viability assays were used to test functionality of SKWX301. To examine the effect of SKWX301 in mouse models, we employed a syngeneic mouse model. CT26 cells were subcutaneously injected into BALB/c mice and tumor growth and mouse survival were analyzed.

Results
SKWX301 can prevent human macrophage phagocytosis of cancer cells in vitro. Combination of low dose SKWX301 and anti-PD1 antibody significantly inhibited tumor growth and increased overall survival in mice. This demonstrates that SKWX301 is effective in both human in vitro models and mouse in vivo models.

Conclusion
Our study has demonstrated a rapid antibody discovery approach and identified a novel human TIM-4 antibody that can serve as a therapeutic for antitumor immunity to improve cancer therapy.
Culture and other direct detection methods to diagnose human granulocytic anaplasmosis
Authors: Aguero-Rosenfeld Maria E , Zentmaier Lois , Liveris Dionysios , Visintainer Paul , Schwartz Ira , Dumler J Stephen , Wormser Gary P 
Published: September 2024

Abstract

Objectives
We sought to assess the performance of 3 laboratory tests on blood specimens for direct detection of Anaplasma phagocytophilum, the cause of human granulocytic anaplasmosis (HGA), in patients tested at a single medical institution in New York State.

Methods
Direct tests included microscopic blood smear examination for intragranulocytic inclusions, polymerase chain reaction (PCR), and culture using the HL-60 cell line. The HGA cases testing positive by only 1 direct test were not included, unless HGA was confirmed by acute or convalescent serology using an indirect immunofluorescent assay.

Results
From 1997 to 2009, 71 patients with HGA were diagnosed by at least 1 of the 3 direct test methods. For the subgroup of 55 patients who were tested using all 3 methods, culture was positive for 90.9% (50/55) vs 81.8% (45/55) for PCR vs 63.6% (35/55) for blood smear (P =.002). Most cultures (79.3%) were detected as positive within 1 week of incubation.

Conclusions
Although using culture to detect A phagocytophilum is likely not amenable for implementation in most hospital laboratories, in our experience, culture had the highest yield among the direct tests evaluated.
Early overyielding in a mixed deciduous forest is driven by both above- and below-ground species-specific acclimatization
Authors: Werner Ramona , Gasser Lisa T , Steinparzer Matthias , Mayer Mathias , Ahmed Iftekhar U , Sandén Hans , Godbold Douglas L , Rewald Boris 
Published: September 2024

Abstract

Background and Aims
Mixed forest plantations are increasingly recognized for their role in mitigating the impacts of climate change and enhancing ecosystem resilience. Yet, there remains a significant gap in understanding the early-stage dynamics of species trait diversity and interspecies interactions, particularly in pure deciduous mixtures. This study aims to explore the timing and mechanisms by which trait diversity of deciduous species and competitive interactions influence yield, carbon allocation and space occupation in mixed forests, both above and below ground.

Methods
A forest inventory was conducted in planted monocultures, two-species and four-species mixtures of European Acer, Tilia, Carpinus and Quercus, representing a spectrum from acquisitive to conservative tree species. Effects of competition were assessed with linear mixed-effects models at the level of biomass and space acquisition, including leaf, canopy, stem and fine root traits.

Key Results
Early above-ground growth effects were observed 6 years post-planting, with significant biomass accumulation after 8 years, strongly influenced by species composition. Mixtures, especially with acquisitive species, exhibited above-ground overyielding, 1.5–1.9 times higher than monocultures. Fine roots showed substantial overyielding in high-diversity stands. Biomass allocation was species specific and varied markedly by tree size and the level of diversity and between acquisitive Acer and the more conservative species. No root segregation was found.

Conclusions
Our findings underscore the crucial role of species trait diversity in enhancing productivity in mixed deciduous forest plantations. Allometric changes highlight the need to differentiate between (active) acclimatizations and (passive) tree size-related changes, but illustrate major consequences of competitive interactions for the functional relationship between leaves, stem and roots. This study points towards the significant contributions of both above- and below-ground components to overall productivity of planted mixed-species forests.
Optimization and application of digital droplet PCR for the detection of SARS-CoV-2 in saliva specimen using commercially available kit
Authors: Kaisar Maria M M , Kristin Helen , Wijaya Fajar A , Rachel Clarissa , Anggraini Felicia , Ali Soegianto 
Published: September 2024

Abstract
The coronavirus disease-19 pandemic has resulted in a significant global health crisis, causing hundreds of millions of cases and millions of deaths. Despite being declared endemic, SARS-CoV-2 infection continues to pose a significant risk, particularly for immunocompromised individuals, highlighting the need for a more sensitive and specific detection. Reverse transcription digital droplet polymerase chain reaction (RT-ddPCR) possesses a sensitive and absolute quantification compared to the gold standard. This study is the first to optimize RT-ddPCR for detecting SARS-CoV-2 in saliva specimens using a commercially available RT-qPCR kit. Optimization involved the assessment of the RT-ddPCR reaction mixture, annealing temperature adjustments, and validation using 40 stored saliva specimens. RT-qPCR was used as a reference method in this study. Compatibility assessment revealed that ddPCR Supermix for Probes (no dUTP) was preferable with an optimal annealing temperature of 57.6°C. Although a 25% higher primer/probe concentration provides a higher amplitude in droplet separation of positive control, the number of copy numbers decreased. An inverse correlation between Ct value and copy number concentration was displayed, presenting that the lower the Ct value, the higher the concentration, for the N and E genes with r2 values of 0.98 and 0.85, respectively. However, ORF1ab was poorly correlated (r2 of 0.34). The sensitivity of targeted and E genes was 100% and 93.3%, respectively; as for the specificity, the percentage ranged from 80.8% to 91.3%. This study implicates the applicability of a modified method in the ddPCR platform for similar types of pathogens using saliva specimens.
Imaging of thoracic tuberculosis: pulmonary and extrapulmonary
Authors: Pattamapaspong Nuttaya , Kanthawang Thanat , Peh Wilfred C G , Hammami Nadia , Bouaziz Mouna Chelli , Ladeb Mohamed Fethi 
Published: September 2024

Abstract
Tuberculosis (TB) remains the leading cause of death from a single infectious agent globally, despite being a potentially curable disease. This disease typically affects the lungs but may involve many extrapulmonary sites, especially in patients with risk factors such as HIV infection. The clinical features of extrapulmonary TB may mimic many different disease entities, particularly at less common thoracic sites such as the heart, chest wall, and breast. Imaging has an important role in the early diagnosis of TB, helping to detect disease, guide appropriate laboratory investigation, demonstrate complications, and monitor disease progress and response to treatment. Imaging supports the clinical objective of achieving effective treatment outcome and complication prevention. This review aims to highlight the imaging spectrum of TB affecting both pulmonary and extrapulmonary sites in the thorax. We also briefly provide key background information about TB, such as epidemiology, pathogenesis, and diagnosis.
Hypoxia-responsive zinc finger E-box-binding homeobox 2 (ZEB2) regulates a network of calcium-handling genes in the injured heart
Authors: Gladka Monika M , Kohela Arwa , de Leeuw Anne E , Molenaar Bas , Versteeg Danielle , Kooijman Lieneke , van Geldorp Mariska , van Ham Willem B , Caliandro Rocco , Haigh Jody J , van Veen Toon A B , van Rooij Eva 
Published: September 2024

Abstract

Aims
Intracellular calcium (Ca2+) overload is known to play a critical role in the development of cardiac dysfunction. Despite the remarkable improvement in managing the progression of heart disease, developing effective therapies for heart failure (HF) remains a challenge. A better understanding of molecular mechanisms that maintain proper Ca2+ levels and contractility in the injured heart could be of therapeutic value.

Methods and results
Here, we report that transcription factor zinc finger E-box-binding homeobox 2 (ZEB2) is induced by hypoxia-inducible factor 1-alpha (HIF1α) in hypoxic cardiomyocytes and regulates a network of genes involved in Ca2+ handling and contractility during ischaemic heart disease. Gain- and loss-of-function studies in genetic mouse models revealed that ZEB2 expression in cardiomyocytes is necessary and sufficient to protect the heart against ischaemia-induced diastolic dysfunction and structural remodelling. Moreover, RNA sequencing of ZEB2-overexpressing (Zeb2 cTg) hearts post-injury implicated ZEB2 in regulating numerous Ca2+-handling and contractility-related genes. Mechanistically, ZEB2 overexpression increased the phosphorylation of phospholamban at both serine-16 and threonine-17, implying enhanced activity of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a), thereby augmenting SR Ca2+ uptake and contractility. Furthermore, we observed a decrease in the activity of Ca2+-dependent calcineurin/NFAT signalling in Zeb2 cTg hearts, which is the main driver of pathological cardiac remodelling. On a post-transcriptional level, we showed that ZEB2 expression can be regulated by the cardiomyocyte-specific microRNA-208a (miR-208a). Blocking the function of miR-208a with anti-miR-208a increased ZEB2 expression in the heart and effectively protected from the development of pathological cardiac hypertrophy.

Conclusion
Together, we present ZEB2 as a central regulator of contractility and Ca2+-handling components in the mammalian heart. Further mechanistic understanding of the role of ZEB2 in regulating Ca2+ homeostasis in cardiomyocytes is an essential step towards the development of improved therapies for HF.