bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan E-Modul Berbasis CTL Materi Suhu dan Kalor Di Kelas XI SMA Negeri 1 Torjun
Authors: Biroso Syaidin Joyo , Saputro Sigit Dwi 
Published: October 2024

Buku merupakan sumber belajar yang memegang peranan penting kesuksesan dari peserta didik. Banyaknya visualisasi pada pembahasan suhu dan kalor tidak dapat difasilitasi oleh buku teks. Modul elektronik (E-Modul) menjadi penting untuk dapat menjelaskan suhu dan kalor secara kontekstual. Penelitian ini bertujuan untuk mengembangan modul elektronik berbasis CTL (Contextual Teaching and Learning) materi suhu dan kalor di kelas XI SMA. Penelitian ini menggunakan model penelitian ADDIE yang mempunyai beberapa tahapan seperti Analysis (analisis), Design (perencanaan), Development (pengembangan), Implementation (penerapan), Evaluation (evaluasi). Subjek penelitian siswa kelas XI SMAN 1 Torjun dengan instrument penelitian meliputi lembar validasi dan angket respon siswa. Hasil dari penelitian ini memiliki kriteri sangat valid karena mendapatkan 88% dari ahli media, 84% dari ahli materi, 94,78% dari ahli konstruk, sedangkan dari uji coba kelompok kecil mendapatkan hasil 82.7% dan uji kelompok besar mendapatkan hasil 87,9% dengan kriteria interpretasi sangat baik. Dapat disimpulkan bahwa pengembangan E-Modul berbasis CTL materi suhu dan kalor di kelas XI SMA layak digunakan.
Mechanism and Data Fusion Method for Predicting Wear and Life of Polycrystalline Diamond Compact Bits Based on the Gaussian Process Regression
Authors: Yan Zhi , Fan Honghai , Song Xianzhi , Zhang Hongbao , Zhu Zhaopeng , Liu Yuhan , Diao Haoyu , Ye Yuguang 
Published: October 2024

Summary
Subterranean oil and gas reserves are abundant, offering significant potential for exploration and development. However, oil and gas drilling often suffers from low efficiency due to the dense rock layers encountered. A major cause of this inefficiency is the rapid wear of bits, which significantly reduces their performance. This not only increases the time spent on inefficient drilling but also leads to frequent bit changes, adding to nonproductive time.
Therefore, this study focuses on the wear prediction of the widely used polycrystalline diamond compact (PDC) bit in oil and gas drilling operations. In this study, we focused on exploring and validating the smooth wear failure mode of PDC bits in sandstone and mudstone formations. Based on this pattern, we modified the traditional wear mechanism model to suit a data-driven approach and integrated the nonparametric intelligent algorithm, Gaussian process regression (GPR), which performs well with small sample data, for characterizing bit performance. Finally, we applied an adaptive differential evolution (ADE) algorithm to extract the cumulative wear characteristics curve that leads to the degradation of bit performance.
This method has been applied to multiple wells in the southwestern China block and the South China Sea block, achieving more than 90% accuracy in model predictions with small sample data. Furthermore, when this method is incorporated into an engineering parameter optimization model, it further unlocks the potential for bit penetration. In practical field applications, it not only enhances the bit footage but also significantly improves overall time efficiency by 11% and 59%, respectively. The application of this method can assist field engineers in identifying inefficient states in oil and gas drilling operations, thereby reducing nonproductive operation time and guiding engineering parameters to enhance drilling efficiency.
Identification of channel shifting patterns and bank erosion-prone sites and challenges of riverine livelihood in the lower Tista River Basin, India
Authors: Mitra Rajib , Das Jayanta 
Published: October 2024

Abstract

River channels shifting and bank erosion behaviour in fluvial environments often vary and are caused by both physical and anthropogenic elements. Riverine hazards like bank erosion and course alterations offer severe issues to the riparian villages along the lower basin of the Tista River in Jalpaiguri and Koch Bihar District of India, which substantially influence the livelihoods and essential satisfaction of people living there. This research addressed river channel shifting tendency and identified major bank erosion-prone villages along the lower course of the Tista River and challenges to the livelihoods of the riparian inhabitants. Along with these, land use and land cover changes of the riparian villages since 1993–2023 have been assessed with accuracy testing based on Kappa co-efficient. The results of this study observed that on the right bank of the Tista River, migration is occurring at a rapid pace. Due to the consequences of numerous riverine hazards, the demographic profile of the riparian villages (viz., Case Study-I: Domohani village in Jalpaiguri District) exhibited a negative tendency in the rate of population growth. The study of the riparian villages' changes in land use and cover reveals 20% decrease in vegetation cover, and both sandbars and water bodies witnessed a declining quantity. The household survey was conducted based on Cochran's method (1963); acquired results demonstrated that floods, bank erosion, and the Tista River's channel shifting behaviour negatively impacted the majority (more than 80%) of the inhabitant's income. The continuous erosion threatens the stability of the riparian villages and necessitates measures to protect riverbanks and prevent further damage. By acknowledging these hazards and implementing appropriate measures, riparian villages can enhance their resilience, protect their livelihoods, and ensure the well-being of their communities in the face of these natural threats.
The Australian clinical trial landscape: Perceptions of rural, regional, and remote health service capacity and capability
Authors: Pinchbeck Jenna , Johnston Karen , Farrington Alison , McPhail Steven , Larkins Sarah 
Published: October 2024

Abstract

Background: Access to clinical trials by rural, regional, and remote Australians is limited, adding to the current health inequity between rural and metropolitan populations. The Australasian Teletrial Model was developed to bring clinical trials ‘closer to home’. In 2020, the Australian Teletrial Program was funded to expand and support the uptake of the model across six Australian states and territories. The aim of this study was to explore and describe the clinical trial landscape in Australia prior to the implementation of the Australian Teletrial Program with a particular focus on rural, regional and remote health services.
Methods: This qualitative study provides a descriptive exploration of the clinical trial landscape across rural, regional, and remote Australia. Data were obtained from semi-structured interviews (n=33) and one focus group (n=5) involving clinical trial stakeholders between August 2022 and May 2023. Deductive then inductive thematic analysis used the broad topic areas of the interview schedule as a framework, as follows: education and training, workforce, equipment and services, clinical trial sites, participant recruitment and clinical trial approval process.
Results: This study identified barriers that are generalizable to the Australian clinical trial landscape and those specific to the rural, regional, and remote health service context. The main barriers to conducting clinical trials in rural, regional, and remote areas were lack of investment and engagement by health service executives, workforce limitations, inconsistent training, lack of physical infrastructure and competing clinical priorities. Despite these challenges, clinicians reported enthusiasm to conduct clinical trials and opportunities were reported for these health services to partner with larger metropolitan/regional health services, regional universities, and communities to support the growth of clinical trial capability and capacity.
Conclusions: The clinical trial landscape in Australian health services varies in terms of quality and availability of training, workforce capacity, executive support, site capability, and approval processes. The ATP has an immense opportunity to overcome some of the reported challenges by supporting capacity and capability building. Ultimately, however, sustainable reform to bring trials closer to home requires a collaborative approach that considers implementation strategies across all levels of the health service and government, alongside other initiatives.
The effect of timing on handgrip strength test in the determination of malnutrition status in patients undergoing haemodialysis therapy
Authors: Cremona Alexandra , McCarthy Rachel , Fitzgerald Jane , Kilkelly Alex , Hayes Kevin , Reddan Donal 
Published: October 2024

Abstract

Background
The incidence of end-stage renal disease (ESRD) in Ireland has increased by 2.3% annually over the last decade. Patients undergoing haemodialysis are particularly susceptible to protein-energy malnutrition (PEM), a critical predictor of morbidity and mortality. The subjective global assessment (SGA) tool is commonly used to assess nutritional status, but its effectiveness in detecting malnutrition within this cohort remains uncertain. Similarly, handgrip strength (HGS) has been proposed as an indicator of PEM due to its association with poorer renal outcomes. However, there is no standardized protocol for HGS measurement, and data on the optimal timing of assessment are limited.
Aim
This study aims to determine the optimal timing for HGS measurement to assess malnutrition status in patients receiving haemodialysis treatment.
Methods
A total of 101 participants were recruited from dialysis units in Galway, Ireland. The SGA tool and three repeated HGS measures were administered to each patient before, during, and after dialysis. Malnutrition status was assessed using the SGA tool and the Irish Nutrition and Dietetic Institute (INDI) HGS reference values.
Results
The sample comprised 101 participants (64.4% males, 35.6% females) with a median age of 69 years (range: 30–95). Pre-dialysis HGS measurements were higher than those recorded during dialysis (median: 23.5kg [IQR: 16.3] vs. 22.7kg [IQR: 14.7], p < 0.0001). No significant difference was found between pre- and post-dialysis measurements (23.5kg [IQR: 16.3] vs. 23.0kg [IQR: 14.8], p = 0.052). HGS values during dialysis were lower than post-dialysis (22.7kg [IQR: 14.7] vs. 23.0kg [IQR: 14.8], p = 0.047). The SGA identified 18.8% (n = 19) of participants as malnourished, with 16.8% (n = 17) being mildly/moderately malnourished and 2% (n = 2) severely malnourished. In contrast, 64.4% (n = 65) were considered at risk of PEM according to the INDI reference values for HGS.
Conclusions
Pre-dialysis HGS measurements were the highest among the three time points, indicating that HGS should be measured before haemodialysis to assess nutritional status accurately. The SGA tool showed limited sensitivity in detecting malnutrition compared to the INDI reference values for HGS.
Prevalence of Fatigue and Perceived Fatigability in Older Adults: A Systematic Review and Meta-analysis
Authors: Hu Ting , Wang Feiling , Duan Qiuchen , Zhao Xueyang , Yang Fen 
Published: October 2024

Abstract

Fatigue is a common health complaint in older adults, but its prevalence varies widely among studies due to differences in populations and assessment tools. The object of this review is to systematically evaluate the prevalence of fatigue and perceived fatigability in older adults. Four major public databases (PubMed, Embase, Web of Science (WoS), and Cochran Library) were searched for eligible studies on the prevalence of fatigue and perceived fatigability in older adults from January 1, 2000 to December 27, 2023. Cochrane Q tests and the I2 statistic were used to assess between-study heterogeneity via Stata16.0. A total of 21 studies involving 17843 participants were included in this study. The prevalence of fatigue in older adults was 42.6%, and the prevalence of perceived physical fatigability and mental fatigability was 58.2% and 24.0%. Meta-analysis showed that the prevalence of perceived physical fatigability among older adults was very high, which varied with regional economic development level, age of the subjects, sample size and representativeness of the subjects. Fatigue is a health dilemma faced by most older adults. To improve quality of life, early and regular fatigue assessment should be part of routine health screening for older adults.
Rare Presentation of Cervical Choriocarcinoma with Metastasis: A Case Report
Authors: Haider Javeria , Mahmood Humera , Faheem Muhammad , Khurshid Shaista , MBBS Abdullah 
Published: October 2024

Abstract

Introduction:
Choriocarcinoma of the cervix is an extremely rare sporadic disease with an incidence of 0.76 to 4%. This malignant form of gestational trophoblastic disease typically originates in the uterus but can occasionally arise in the vagina, fallopian tubes, vulva, cervix, or pelvic region.
Case Presentation:
Our patient presented with heavy menstrual bleeding and elevated B-HCG levels. She underwent total hysterectomy with bilateral salpingo-oophorectomy (TAH + BSO). Histopathological diagnosis confirmed choriocarcinoma and a post-treatment CT scan revealed lung metastasis. Treatment usually involves combination chemotherapy, which is highly effective, with cure rates reaching 100% in low-risk patients and 80–90% in high-risk patients.
Conclusion:
This report highlights the importance of a meticulous, multidisciplinary approach in managing patients who present with choriocarcinoma at unusual sites like cervix that can easily be missed and misdiagnosed.
Carfilzomib Prescribing Patterns and Outcomes for Relapsed or Refractory Multiple Myeloma: A Real-World Analysis
Authors: Kaur Gurbakhash , Dong Sharlene , Banerjee Rahul , Khan Adeel , Wang Mengru , Wang Xiaoliang , Afghahi Anosheh , Afrough Aimaz , Janakiram Murali , Wang Bo , Cowan Andrew , Sperling Adam , Anderson Larry , Rajkumar S 
Published: October 2024

Abstract

Despite the widespread use of carfilzomib (K) in relapsed/refractory multiple myeloma (RRMM), there is no consensus on optimal K dose in milligrams per square meter (mg/m2) or dosing schedule. We assessed three modern K prescribing patterns in RRMM using a large United States electronic health record-derived database. Our final cohort (n = 486) included 136 patients (28.0%) who received K 56 mg/m2 once weekly (K56-1x), 86 (17.7%) who received 56 mg/m2 twice weekly (K56-2x), and 264 (54.3%) who received 70 mg/m2 once weekly (K70-1x). Between 2016 and 2023, once-weekly dosing became more common: K70-1x proportions changed from 21.1% in 2016 to 50.6% in 2023, K56-1x from 15.8% to 37.0%, and K56-2x from 63.2% to 12.3%. Median real-world progression-free survival was 13.0 months [95% confidence interval (CI) 11.2-20.7] for K56-1x, 13.2 months (95% CI 9.0-28.1 months) for K56-2x, and 10.9 months (95% CI 9.9-15.3 months) for K70-1x; these differences were not statistically significant (log-rank p = 0.46). The prevalence of heart failure was comparable (<5% in all cohorts). In summary, our findings do not support improved outcomes with twice-weekly carfilzomib in RRMM. K56-1x may provide the best balance of efficacy, safety, and avoidance of time toxicity from frequent infusions.
Brain Metabolism in Pre-frontal Cortex and Insula Areas in Patients With Occlusal Splint for Temporomandibular Muscle Disorders
Authors: Cabezas-Bernhardt Gerson Oswaldo , Villavicencio-Caparo Ebingen , Tay Lidia Yileng 
Published: October 2024

Abstract

Background: There is a relationship between anxiety/depression and the development of disorders in the temporomandibular joint (TMJ), but it is unknown whether treatment for these conditions could have any effect on emotional symptoms. The aim of the present study was to compare brain metabolism in the prefrontal cortex and insula before and after occlusal splint placement in patients with TMJ muscle disorders with anxiety and/or depression. Methods: An experimental study evaluated 23 patients with anxiety and/or depression confirmed by the Hospital Anxiety and Depression Scale (HADS) questionnaire and with TMJ muscle disorders diagnosed by means of clinical examination and the Research Diagnostic Criteria for Temporomandibular Disorders questionnaire. (RDC/TMD), an occlusal splint was then made for condylar decompression 2 mm greater than the mandibular rest space, as confirmed by panoramic radiography before and after the placement of the occlusal splint. Brain metabolism in response to a positive or negative stimulus was evaluated by functional magnetic resonance imaging (fMRI), both with and without occlusal splints.
Results: In both the prefrontal cortex and insula, a statistically significant difference (p <0.001 Wilcoxon test) was found between the stimulus reading without a splint and the stimulus reading with an occlusal splint.
Conclusion: There was a significant difference in brain metabolism in both the prefrontal cortex and insula area, either with positive or negative stimulation before and after occlusal splint placement, between patients with TMJ muscle disorders.
TCF7L2 promotes tumor progression by regulating hypoxia-inducible factor 1 alpha through activating the PI3K/AKT signaling pathway in colorectal carcinoma
Authors: Cheng Yong , Tang Kang , Gong Jianping , Li Yang 
Published: October 2024

Abstract

Hypoxia is a critical pathogenic factor in cancer development and metastasis. The pivotal role of hypoxia-inducible factor 1α (HIF-1α) in tumor progression under hypoxic conditions is well-documented. However, the specific mechanisms by which HIF-1α contributes to colorectal cancer (CRC) progression remain inadequately elucidated. In this study, we observed an upregulation of Transcription Factor 7-like 2 (TCF7L2) in CRC cells under hypoxic conditions. Meanwhile, hypoxia-induced overexpression of TCF7L2 plays a pivotal role in the proliferation, apoptosis, cell cycle arrest, migration, invasion, epithelial-mesenchymal transition (EMT), and cancer stem cell (CSC) characteristics of colorectal cancer (CRC) cells in vitro. Additionally, our findings indicate that the inhibition of TCF7L2 results in a significant reduction of tumor growth in vivo. Mechanistically, hypoxia-induced up-regulation of TCF7L2 expression occurs in a HIF-1α-dependent manner. Chromatin immunoprecipitation (ChIP) assays demonstrated increased HIF-1α binding to the promoter sequence of TCF7L2 following hypoxic stimulation. Furthermore, our findings indicate that TCF7L2 plays an oncogenic role in colorectal cancer (CRC) by activating the PI3K/AKT signaling pathway. Additionally, we observed that elevated expression levels of both HIF-1α and TCF7L2 in CRC specimens are associated with aberrant clinicopathological features. Co-expression of TCF7L2 and HIF-1α predicts a poor prognosis in CRC patients. Targeting TCF7L2 is a promising approach to colorectal cancer therapy.
Establishment of a nomogram prediction model for severe primary lower limb lymphedema
Authors: Li Xingpeng , Zhang Yimeng , Liu Mengke , Wang Jingru , Guo Jia , Ren Jie , Shen Wenbin , Yue Yunlong , Wang Rengui 
Published: October 2024

Abstract

Background
The International Society of Lymphology (ISL) guidelines have established grading criteria for primary lower limb lymphedema (PLEL), but there is a lack of model on a unified standard for assessing the severity of the disease.
Purpose
The aim of this study was to establish and validate a predictive model for evaluating severe PLEL.
Methods and Materials:
This retrospective study included 226 patients with unilateral PLEL from 2018 to 2023, who were divided into non-severe (143 cases) and severe (83 cases) groups according to the ISL grading criteria. The two groups of patients had a total of 26 MRI and 15 clinical features recorded. One-way ANOVA was performed first, followed by multi-factor ANOVA, and logistic regression was used to construct a nomogram prediction model. The model’s performance was evaluated via the area under the receiver operating characteristic (ROC) curve (AUC), decision curve analysis, and internal validation.
Results
The predictive model identified six independent risk factors associated with the severity of PLEL, including the parallel line sign, crescent sign, longitudinal range, band sign thickness, fat area, and fat diameter. The nomogram model established based on the above six factors predicts a training set AUC of 0.908 (95% CI: 0.868–0.947) for severe PLEL, with a sensitivity of 0.868, specificity of 0.832, accuracy of 0.845, precision of 0.75. The AUC of the validation set was 0.891 (95% CI: 0.847 ~ 0.935), the sensitivity was 0.831, the specificity was 0.825, the accuracy was 0.827, the precision was 0.734. In decision curve analysis, more net benefit can be achieved when the threshold probability is between 1% and 90%.
Conclusions
The severity risk prediction model based on MRI and clinical practice has good discriminatory power and accuracy in evaluating the severity of PLEL which can provide a reference for individualized clinical prediction of PLEL.
Two dramatically different clinical scenarios of neonatal Echovirus-11 infection in late preterm male twins: a case report and review of the literature
Authors: Perniciaro Simona , Proietti Caterina , bossi Angela , maragliano Roberta , facco Carla , novazzi Federica , mancini Nicasio , agosti Massimo Agostino 
Published: October 2024

Abstract

Background
Enterovirus is a well-known cause of infection in all age groups, with particular importance for neonates with both vertically and horizontally transmission. Neonatal clinical manifestations are highly variable and mostly is asymptomatic, but severe infections are described such as myocarditis, meningitis, encephalitis, hepatitis, coagulopathy, pneumonia and viral sepsis.
Since 2022, The World Health Organization (WHO) has recently reported an increasing number of severe neonatal infection associated with a new variant of Echovirus 11 (E-11).
Many of the infants described with E-11infections in a case reports series were preterm, male and twins. Despite the criticality of neonatal disease, the clinical management remains primarily supportive and therapeutic options are unfortunately few.
Case presentation
We present the case of male dichorionic diamniotic (DCDA) late-preterm twins, born in December 2023 at Filippo del Ponte Hospital in Varese (Northen Italy) with early Echovirus 11 infection. They had two dramatically different clinical scenarios and one of them developed a severe and fatal hemorrhage-hepatitis syndrome.
Conclusion
Our experience has the purpose to emphasize public health attention to Echovirus 11 neonatal infections and their rare dramatically neonatal clinical presentations. Prematurity, host genetic predisposition and vertical transmission seem to be strong risk factors for severe infections, but it still need to be elucidated. According toprevious Italian report, a surveillance protocols in all cases with unexpected clinical presentations and sequencing complete genome in order to better understand typing and molecular characterization of emerging and re-emerging pathogenic variants and new strains are strongly recommend in Italy.