bluuebunny/crossref_metadata_2025_split huggingface dataset:
Astroglial MicroRNA-219-5p in the Ventral Tegmental Area Regulates Nociception in Rats
Authors: Zhang Song , Yang Xiao-Na , Zang Ting , Luo Jun , Pan Zhiqiang , Wang Lei , Liu He , Liu Di , Li Yan-Qiang , Zhang Yao-Dong , Zhang Hongxing , Ding Hai-Lei , Cao Jun-Li 
Published: June 2017

Abstract

Background
The authors previously reported that noncoding microRNA miR-219-5p is down-regulated in the spinal cord in a nociceptive state. The ventral tegmental area also plays critical roles in modulating nociception, although the underlying mechanism remains unknown. The authors hypothesized that miR-219-5p in the ventral tegmental area also may modulate nociception.

Methods
The authors studied the bidirectional regulatory role of ventral tegmental area miR-219-5p in a rat complete Freund’s adjuvant model of inflammatory nociception by measuring paw withdrawal latencies. Using molecular biology technologies, the authors measured the effects of astroglial coiled-coil and C2 domain containing 1A/nuclear factor κB cascade and dopamine neuron activity on the down-regulation of ventral tegmental area miR-219-5p–induced nociceptive responses.

Results
MiR-219-5p expression in the ventral tegmental area was reduced in rats with thermal hyperalgesia. Viral overexpression of ventral tegmental area miR-219-5p attenuated complete Freund’s adjuvant–induced nociception from 7 days after complete Freund’s adjuvant injection (paw withdrawal latencies: 6.09 ± 0.83 s vs. 3.96 ± 0.76 s; n = 6/group). Down-regulation of ventral tegmental area miR-219-5p in naïve rats was sufficient to induce thermal hyperalgesia from 7 days after lentivirus injection (paw withdrawal latencies: 7.09 ± 1.54 s vs. 11.75 ± 2.15 s; n = 8/group), which was accompanied by increased glial fibrillary acidic protein (fold change: 2.81 ± 0.38; n = 3/group) and reversed by intraventral tegmental area injection of the astroglial inhibitor fluorocitrate. The nociceptive responses induced by astroglial miR-219-5p down-regulation were inhibited by interfering with astroglial coiled-coil and C2 domain containing 1A/nuclear factor-κB signaling. Finally, pharmacologic inhibition of ventral tegmental area dopamine neurons alleviated this hyperalgesia.

Conclusions
Down-regulation of astroglial miR-219-5p in ventral tegmental area induced nociceptive responses are mediated by astroglial coiled-coil and C2 domain containing 1A/nuclear factor-κB signaling and elevated dopamine neuron activity.
Euroscore Performance in Minimally Invasive Cardiac Surgery
Authors: Margaryan Rafik , Moscarelli Marco , Gasbarri Tommaso , Bianchi Giacomo , Kallushi Enkel , Giuseppe Cerillo Alfredo , Farneti Pierandrea , Solinas Marco 
Published: June 2017

Objective Prediction of operative risk in adults undergoing cardiac surgery remains a challenge. The European System for Cardiac Operative Risk Evaluation (EuroSCORE) is one of the most commonly used in clinical settings. Recently, the new EuroSCORE II was published attempting to improve the accuracy of risk prediction. We sought to assess the predictive value of EuroSCORE or EuroSCORE II in selected field of minimally invasive cardiac surgery. Methods Patients who underwent cardiac surgery operation with minimally invasive approach from 2007 to 2013 identified from prospective cardiac surgical database. Additional variables included in EuroSCORE II, but not in original EuroSCORE, were retrospectively collected via electronic health records reviewing. The C-statistic was calculated for the EuroSCORE (additive and logistic) and EuroSCORE II. The Hosmer-Lemeshow test was used to assess model calibration by comparing observed and expected morality in number of risk strata. Results There were 39 hospitals deaths (1.6%). A total of 2472 patients were identified from the main database. The mean ± SD logistic EuroSCORE was 7.6 ± 8.3, mean ± SD additive EuroSCORE was 6.1 ± 2.7, and mean ± SD EuroSCORE II was 2.9 ± 4.2. EuroSCORE logistic model performed with substantial accuracy of 0.78, EuroSCORE additive performed with accuracy of 0.78, and EuroSCORE II performed as almost perfect 0.82. Model calibration was poor in EuroSCORE II (χ2 = 17.57, P = 0.02), calibration for logistic EuroSCORE was also poor (χ2 = 140.58, P < 0.01), and additive model also (χ2 = 94.95, P < 0.01). The area under the curve was high in all algorithms; logistic EuroSCORE was 0.78 (95% confidence interval = 0.71–0.85), additive EuroSCORE was 0.79 (95% confidence interval = 0.71–0.86), and EuroSCORE II was 0.82 (95% confidence interval = 0.75–0.89). Conclusions In overall settings, original EuroSCORE and EuroSCORE II perform poorly in minimally invasive operation conditions. Data suggest that EuroSCORE could not be used for estimating operative risks correctly. New risk score should be explored, developed, and implemented for selective minimally invasive cohorts.
Update in the management of pediatric psoriasis
Authors: Tangtatco Jennifer Aileen Ang , Lara-Corrales Irene 
Published: June 2017

Purpose of review
Psoriasis is a multifactorial, chronic, inflammatory skin disease that may represent a therapeutic challenge in children. This review aims to provide a framework for the management of pediatric psoriasis, emphasizing in new insights and considerations for management. It will focus on new disease associations and innovative treatment modalities that challenge current approach of psoriasis in children.

Recent findings
There is an increasing body of literature both in adults and in children linking psoriasis with different comorbidities. This new evidence points to the need of addressing psoriasis as a systemic disease and suggests the need for screening and creating awareness of possible associations. In a similar manner, newer medications are also being investigated in children. Recent publications report on the efficacy and safety of biologics for psoriasis in pediatric patients.

Summary
The review provides better understanding of present and future risks of untreated and uncontrolled psoriasis in children and at the same time the benefits and risks of new treatments available.
Probiotics for the Prevention of Nosocomial Diarrhea in Children
Authors: Hojsak Iva , Szajewska Hania , Canani Roberto B. , Guarino Alfredo , Indrio Flavia , Kolacek Sanja , Orel Rok , Shamir Raanan , Vandenplas Yvan , van Goudoever Johannes B. , Weizman Zvi ,   ESPGHAN Working Group for Probiotics/Prebiotics
Published: June 2017

ABSTRACTThis document provides recommendations developed by the ESPGHAN Working Group on Probiotics and Prebiotics on the role of probiotics in the prevention of nosocomial diarrhea in children based on a systematic review of previously completed systematic reviews and of subsequently published randomized controlled trials. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation guidelines. Recommendations were given only if at least 2 randomized controlled trials examined the same probiotic strain. Based on currently available evidence the Working Group recommends using Lactobacillus rhamnosus GG if the use of probiotics for preventing nosocomial diarrhea in children is considered.
Introducing the International Confederation of Plastic Surgery Societies: ICOPLAST
Authors: Rakhorst Hinne A. , Badran Hassan , Clarke Howard M. , Cooter Rodney , Evans Gregory R. D. , Kirschbaum Julio Daniel , Koh Kyung Suk , Lazier Carol , Murphy Robert X. , Nakatsuka Takashi , Piccolo Nelson Sarto , Perks Graeme 
Published: June 2017

Summary:
This article describes the formation of the International Confederation of Plastic Surgery Societies (ICOPLAST) as a novel, transparent, dynamic, and proactive confederation of national plastic surgery societies. ICOPLAST aspires to provide a voice for the entire international community of plastic surgeons. ICOPLAST has been designed to benefit the patient, plastic surgery as a profession, and each individual plastic surgeon. Its principal objective is to enhance international communication, education, and advocacy processes to ultimately improve patient outcomes for plastic surgery patients globally. The new ICOPLAST’s focus is to add true value for patients. ICOPLAST’s evolution, philosophy, governance, and bylaws are explained and all societies worldwide are encouraged and cordially invited to join. An open and warm invitation is provided. Additional information is found at www.ICOPLAST.org.
Five Operations That Give the Best Results after Brachial Plexus Injury
Authors: Maldonado Andrés A. , Bishop Allen T. , Spinner Robert J. , Shin Alexander Y. 
Published: June 2017

Summary:
Treatment of brachial plexus injuries has improved slowly over the past 45 years. Changes in strategy, techniques, microsurgical equipment, and technology have expanded the surgical options for reconstructing these life-altering, highly complex injuries. The surgical techniques available include neurolysis, nerve repair, nerve grafting, nerve transfers, tendon transfer, muscle transfer, and other soft- and bony-tissue procedures. In this article, the authors have selected five surgical procedures (i.e., Oberlin procedure, Leechavengvongs procedure, free functional muscle transfer, radial nerve tendon transfers, and C5-C6 nerve grafting in obstetric birth palsy) that have consistently yielded good results in patients who require surgical reconstruction.
Current Clinical Applications of Fat Grafting
Authors: Khouri Roger K. , Khouri Roger K. 
Published: June 2017

Learning Objectives:
After reading this article, the participant should be able to: 1. Understand the theory and principles behind successful avascular fat transfer; 2. Apply these principles into techniques that yield safe and successful fat grafting operations; 3. Identify the well-established indications and limitations of the various fat grafting operations as well as the indications that require additional clinical and translational research.

Summary:
In this article, the authors summarize the established principles and techniques of fat grafting, discuss debated topics, and present both the well-established and the novel clinical applications of fat grafting.
Is it the End for Urologic Pelvic Laparoscopic Surgery?
Authors: Athanasiadis Grigorios , Bourdoumis Andreas , Masood Junaid 
Published: June 2017

Aim:
To scrutinize the rapid development of robotic versus traditional laparoscopic technique in pelvic urologic surgery.

Introduction:
In the last few decades, advances in research and development have led to tremendous progress in medical diagnostics and treatment of disease. Minimally invasive surgery has moved from experimental to becoming the dominant form of surgical management across the surgical specialties. Laparoscopy is nowadays used widely in abdominal surgery, from simple diagnostic laparoscopy to complex colorectal and gynecologic cancer procedures.

Methods:
A literature search of electronic databases (PubMed, Medscape, Embase) using the key words: “pelvic laparoscopy, urologic oncology, robotic surgery, minimally invasive access” was performed for all relevant articles in the English language. Data were extrapolated from the abstracts alone to avoid subjective bias in drawing conclusions.

Results:
Telemedicine and telesurgery, the diagnostic and operative process is conducted from a distance. The surgeon uses computer-assisted surgery away from the bedside via a robotic system and performs the surgical task at hand. In pelvic urological cancer surgery the use of robotic technique expands to female and reconstructive procedures as well. The leap forward is so massive, that traditional laparoscopic surgery is starting to be considered less, with a growing number of organizations being now more interested in developing a robotic service. Minimally invasive surgical techniques aim to improve surgical outcome in conjunction with delivery of high-quality patient care. Quality studies demonstrating superiority and cost effectiveness are lacking, however.

Conclusions:
Although tremendous accomplishments took place over a few years, there is still a lot of ground to be covered in standardizing the learning process and evaluating the outcome from the application of new technologies in the field of robotic pelvic surgery.
Ephemeral-habitat colonization and neotropical species richness ofCaenorhabditisnematodes
Authors: Ferrari Céline , Salle Romain , Callemeyn-Torre Nicolas , Jovelin Richard , Cutter Asher D. , Braendle Christian 
Published: June 2017

AbstractBackgroundThe drivers of species co-existence in local communities are especially enigmatic for assemblages of morphologically cryptic species. Here we characterize the colonization dynamics and abundance of nine species ofCaenorhabditisnematodes in neotropical French Guiana, the most speciose known assemblage of this genus, with resource use overlap and notoriously similar outward morphology despite deep genomic divergence.MethodsTo characterize the dynamics and specificity of colonization and exploitation of ephemeral resource patches, we conducted manipulative field experiments and the largest sampling effort to date forCaenorhabditisoutside of Europe. This effort provides the first in-depth quantitative analysis of substrate specificity forCaenorhabditisin natural, unperturbed habitats.ResultsWe amassed a total of 626 strain isolates from nine species ofCaenorhabditisamong 2865 substrate samples. With the two new species described here (C. astrocaryaandC. dolens), we estimate that our sampling procedures will discover few additional species of these microbivorous animals in this tropical rainforest system. We demonstrate experimentally that the two most prevalent species (C. nouraguensisandC. tropicalis) rapidly colonize fresh resource patches, whereas at least one rarer species shows specialist micro-habitat fidelity.DiscussionDespite the potential to colonize rapidly, these ephemeral patchy resources of rotting fruits and flowers are likely to often remain uncolonized byCaenorhabditisprior to their complete decay, implying dispersal-limited resource exploitation. We hypothesize that a combination of rapid colonization, high ephemerality of resource patches, and species heterogeneity in degree of specialization on micro-habitats and life histories enables dynamic co-existence of so many morphologically cryptic species ofCaenorhabditis.
Causal modeling dissects tumour-microenvironment interactions in breast cancer
Authors: Chlon Leon , Markowetz Florian 
Published: June 2017

AbstractElucidating interactions between cancer cells and their microenvironment is a key goal of cancer research with implications for understanding cancer evolution and improving immunotherapy. Previous studies used association-based approaches to infer relationships in transcriptomic data, but could not infer the direction of interaction. Here we present a causal modeling approach that infers directed interactions between signaling pathway activity and immune activity by anchoring the analysis on somatic genomic changes. Our approach integrates copy number profiles, transcriptomic data, image data and a protein-protein interaction network to infer directed relationships. As a result, we propose 11 novel genomic drivers of T cell phenotypes in the breast cancer tumour microenvironment and validate them in independent cohorts and orthogonal data types. Our framework is flexible and provides a generally applicable way to extend association-based analysis in other cancer types and to other data and clinical parameters.
Integrating lean and visual management in facilities management using design science and action research
Authors: Schultz Audrey Lynn 
Published: June 2017

Purpose
The purpose of this paper is to create a value-based facilities management (FM) workplace by integrating lean principles, lean concepts, and specifically visual management technologies to improve efficiency, transparency, and value in the built environment.

Design/methodology/approach
The original research methodology used design science research framework with an action research (AR) approach. The chosen qualitative research methods included questionnaires, unstructured and semi-structured interviews, and participatory observation in action.

Findings
The facilities asset management department needs to align itself more strategically with organization leadership by understanding core business values, mission, and vision. It is essential they become a partner in creating a value-based contribution to the organizations bottom line and strategic plan. This can be established by embracing lean principles, concepts, and visual technologies, strategically linking the FM and asset management department to the organization holistically. The research acknowledged that a lean visual workplace management system could be introduced in facilities asset management with success. The findings suggest that change management should form part of the lean journey.

Research limitations/implications
The original research was limited in scope to one UK university estates and property services department’s lean journey and their third party outsourced FM service provider.

Originality/value
By using the visual workplace management system to integrate lean and visual management technologies in FM asset management systems value-based FM services and recognition from the C-suite will be achieved. Additionally, a new design science framework with an AR approach was developed as a research method
Positive leadership and adding value – a lifelong journey
Authors: Cameron Kim , Quinn Robert E. , Caldwell Cam 
Published: June 2017

Purpose
Kim Cameron and Robert Quinn are two widely admired world class scholars at the University of Michigan’s Ross School of Business. The purpose of this paper is to explore their personal views about positive leadership and added values over the traditional approach to organizations and leadership.

Design/methodology/approach
This interview was designed to obtain personal insights to positive leadership from world renowned leadership scholars.

Findings
Most people do have something to give that is worthwhile, when they address the question of positive leadership over traditional leadership. The moment we orient people to their highest purpose, there is an incentive for them to close their integrity gap.

Originality/value
Obtaining personal insights from lifelong scholars of leadership by means of personal interviews is paramount in the professional field of leadership.
Who and what set the price of walnuts for small-scale farmers in Southwest China?
Authors: Yan Mei , Terheggen Anne , Mithöfer Dagmar 
Published: June 2017

PurposeDomestic demand for walnuts has been on the rise for the last decades. Consumption outstrips domestic production capacities, which led to increasing prices until recently. Small-scale farmers are at the centre of walnut tree planting and walnut collection efforts. Farmers are now integrated into rapidly expanding agrifood value chains. The purpose of this paper is to investigate the walnut value chain originating in Yunnan (the dominant producer of walnuts in China). The authors are especially interested in the position of small-scale farmers in the chain and the factors affecting the price that they receive.Design/methodology/approachPrice and intra-chain governance information were collected through structured interviews with value chain actors like certified and conventional small-scale farmers, traders, processors, food manufacturers and wholesalers. The resultant price data set was analysed using a multiple regression analysis.FindingsTiming of harvest, distance to market and sales volume are correlated with the village-level price. Farmers are in a market governance segment of the chain. Lead firms (e.g. supermarkets) are price-setters and determine the value distribution, with farmers receiving a smaller share relative to downstream actors’ shares.Research limitations/implicationsImproved connectivity to markets, transparency of standards and price (formation), processing and certification could improve farmers’ profits.Originality/valueThe authors contribute to the growing literature of value chain studies focussing on farmers’ integration into food systems at different scales. The authors investigated the price determinants at the village level and additionally provide information on an organic marketing arrangement.
Convergence in the UK direct real estate market
Authors: Lee Stephen 
Published: June 2017

Purpose
The purpose of this paper is to empirically examine the issue of convergence in the monthly returns, rental growth and yields for ten market segments in the UK direct real estate market, using monthly data over the period from January 1987 to December 2014.

Design/methodology/approach
The methodology used to determine convergence is principal component analysis as it provides an assessment of the extent to which the variance of the market segments can be represented by a single common factor, explaining their long-run behaviour, and the degree of independence between the market segments.

Findings
The results suggest that there is strong evidence of convergence over the entire sample period in relation to monthly returns and yields but less evidence of convergence in rental growth, which confirms the findings in previous studies in international markets.

Practical implications
The evidence also suggests that convergence has increased over the sample period and that convergence is period specific and was particularly strong during and after the period of the Global Financial Crisis, which implies that the UK direct real estate market is largely integrated and as a consequence the extent of diversification potential in the market is still severely limited.

Social implications
The convergence in returns has crucial implications for investors as it leaves investors exposed to the same structural shocks and so magnifies the importance of volatility spillover effects, limits their ability to create well-diversified portfolios and make it more difficult for fund managers to outperform the market.

Originality/value
This is the first paper to examine the convergence in the UK direct real estate market.
How long is UK property cycle?
Authors: Jadevicius Arvydas , Huston Simon Hugh 
Published: June 2017

PurposeThe purpose of this paper is to assess the duration of the UK commercial property cycles, their volatility and persistence to gauge future market direction.Design/methodology/approachThe study employs a novel approach to dissect cycles in a form of a three-step algorithm. First, the Hodrick-Prescott de-trends the selected variables. Second, volatility (measured by the variance) screens periods of atypical fluctuations in the series. Finally, the series is regressed against its past values to assess the level of persistence. The sequential steps screen the length of the cycles in UK commercial property market to facilitate interpretation.FindingsThe estimates suggest that UK commercial property market follows an eight-year cycle. Combined modelling results indicate that the current market trend is likely to change over the coming year. The modelling suggests increasing probability of a market correction in late 2016/early 2017.Practical implicationsThis updated appreciation of the UK commercial property cycle duration allows for better market timing and investment decision making.Originality/valueThe paper adds additional evidence on the contested issue of UK commercial property cycle duration.