bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual orientation identity and tobacco and hazardous alcohol use: findings from a cross-sectional English population survey
Authors: Shahab Lion , Brown Jamie , Hagger-Johnson Gareth , Michie Susan , Semlyen Joanna , West Robert , Meads Catherine 
Published: October 2017

ObjectivesTo assess the association between tobacco and hazardous alcohol use and sexual orientation and whether such an association could be explained by other sociodemographic characteristics.DesignCross-sectional household survey conducted in 2014–2016.SettingEngland, UK.ParticipantsRepresentative English population sample (pooled n=43 866).Main outcomesSexual orientation identity (lesbian/gay, bisexual, heterosexual, prefer-not-to-say); current tobacco and hazardous alcohol use (defined as Alcohol Use Disorders Identification Test Score ≥8). All outcomes were self-reported.ResultsDue to interactions between sexual orientation and gender for substance use, analyses were stratified by gender. Tobacco use prevalence was significantly higher among lesbian/gay (women: 24.9%, 95% CI 19.2% to 32.6%; men: 25.9%, 95% CI 21.3% to 31.0%) and bisexual participants (women: 32.4%, 95% CI 25.9% to 39.6%; men: 30.7%, 95% CI 23.7% to 30.7%) and significantly lower for prefer-not-to-say participants in women (15.5%, 95% CI 13.5% to 17.8%) but not men (22.7%, 95% CI 20.3% to 25.3%) compared with heterosexual participants (women: 17.5%, 95% CI 17.0% to 18.0%; men: 20.4%, 95% CI 19.9% to 21.0%; p<0.001 for omnibus test). Similarly, hazardous alcohol use was significantly more prevalent for lesbian/gay (women: 19.0%, 95% CI 14.0% to 25.3%; men: 30.0%, 25.2%–35.3%) and bisexual participants (women: 24.4%, 95% CI 18.7% to 31.3%; men: 24.3%, 95% CI 17.9% to 32.1%) and lower for prefer-not-to-say participants (women: 4.1%, 95% CI 3.0% to 5.4%; men: 13.7%; 95% CI 11.8% to 16.0%) compared with heterosexuals (women: 8.3%, 95% CI 7.9% to 8.7%; men: 18.4%, 95% CI 17.9% to 18.9%; p<0.001 for omnibus test). However, after adjusting for sociodemographic confounders, tobacco use was similar across all sexual orientation groups among both women and men. By contrast, sexual orientation differences in hazardous alcohol use remained even after adjustment among women but not for bisexual and gay men.ConclusionsIn England, higher rates of tobacco use among sexual minority men and women appear to be attributable to other sociodemographic factors. Higher rates of hazardous alcohol use among sexual minority men may also be attributable to these factors, whereas this is not the case for sexual minority women.
Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling
Authors: Javary Joaquim , Allain-Courtois Nathalie , Saucisse Nicolas , Costet Pierre , Heraud Capucine , Benhamed Fadila , Pierre Rémi , Bure Corinne , Pallares-Lupon Nestor , Do Cruzeiro Marcio , Postic Catherine , Cota Daniela , Dubus Pierre , Rosenbaum Jean , Benhamouche-Trouillet Samira 
Published: October 2017

ObjectiveThe AAA+ ATPase Reptin is overexpressed in hepatocellular carcinoma and preclinical studies indicate that it could be a relevant therapeutic target. However, its physiological and pathophysiological roles in vivo remain unknown. This study aimed to determine the role of Reptin in mammalian adult liver.Design and resultsWe generated an inducible liver-specific Reptin knockout (RepinLKO) mouse model. Following Reptin invalidation, mice displayed decreased body and fat mass, hypoglycaemia and hypolipidaemia. This was associated with decreased hepatic mTOR protein abundance. Further experiments in primary hepatocytes demonstrated that Reptin maintains mTOR protein level through its ATPase activity. Unexpectedly, loss or inhibition of Reptin induced an opposite effect on mTORC1 and mTORC2 signalling, with: (1) strong inhibition of hepatic mTORC1 activity, likely responsible for the reduction of hepatocytes cell size, for decreased de novo lipogenesis and cholesterol transcriptional programmes and (2) enhancement of mTORC2 activity associated with inhibition of the gluconeogenesis transcriptional programme and hepatic glucose production. Consequently, the role of hepatic Reptin in the pathogenesis of insulin resistance (IR) and non-alcoholic fatty liver disease consecutive to a high-fat diet was investigated. We found that Reptin deletion completely rescued pathological phenotypes associated with IR, including glucose intolerance, hyperglycaemia, hyperlipidaemia and hepatic steatosis.ConclusionWe show here that the AAA +ATPase Reptin is a regulator of mTOR signalling in the liver and global glucido-lipidic homeostasis. Inhibition of hepatic Reptin expression or activity represents a new therapeutic perspective for metabolic syndrome.
Exacerbation risk and characterisation of the UK’s asthma population from infants to old age
Authors: Bloom Chloe I , Nissen Francis , Douglas Ian J , Smeeth Liam , Cullinan Paul , Quint Jennifer K 
Published: October 2017

BackgroundFew studies have examined the characteristics of a general asthma population; most have focused on more severe patients or severe exacerbations.MethodsThis population-based cohort study, from April 2007 to September 2015, used linked primary and secondary care electronic healthcare records (Clinical Practice Research Datalink, Hospital Episode Statistics). Characteristics of four age cohorts, ‘Under 5s’, ‘5 to 17s’, ‘18 to 54s’, ‘55+’, were described. Exacerbation risk factors, including asthma severity (measured by the British Thoracic Society (BTS) stepwise approach), were assessed using Poisson regression.Results424 326 patients with current asthma were eligible (n, median follow-up: ‘Under 5s’=17 320, 1 year; ‘5 to 17s’=82 707, 3.3 years; ‘18 to 54s’=210 724, 4 years; ‘55+’=113 575, 5.1 years). Over 60% of the total study population had mild asthma (BTS steps 1/2). There were differences between the cohort’s characteristics, including by gender, disease severity and exacerbation pattern. The rate of exacerbations was highest in the oldest cohort and lowest in the ‘5 to 17s’ cohort (rate per 10 person-years (95% CI), ‘Under 5s’=4.27 (4.18 to 4.38), ‘5 to 17s’=1.48 (1.47 to 1.50), ‘18 to 54s’=3.22 (3.21 to 3.24), ‘55+’=9.40 (9.37 to 9.42)). In all cohorts, exacerbation rates increased with increasing asthma severity, after adjusting for confounders including gender, socioeconomic status, smoking, body mass index, atopy, rhinitis, gastro-oesophageal reflux, anxiety, depression and COPD.ConclusionThe majority of UK patients with asthma had mild asthma and did not experience an exacerbation during follow-up. Patients aged ≥55 years had the lowest proportion with mild asthma and highest rate of exacerbations; the opposite was found in patients aged between 5 and 18 years.
Prevalence and Natural History of Superficial Siderosis
Authors: Pichler Michael , Vemuri Prashanthi , Rabinstein Alejandro A. , Aakre Jeremiah , Flemming Kelly D. , Brown Robert D. , Kumar Neeraj , Kantarci Kejal , Kremers Walter , Mielke Michelle M. , Knopman David S. , Jack Clifford R. , Petersen Ronald C. , Lowe Val , Graff-Radford Jonathan 
Published: October 2017

Background and Purpose—
Superficial siderosis (SS) is characterized by hemosiderin deposition in the superficial layers of the central nervous system and can be seen during postmortem examination or with iron-sensitive magnetic resonance imaging techniques. The distribution of SS may predict the probable underlying cause. This study aimed to report the prevalence and natural history of SS in a population-based study.

Methods—
Brain magnetic resonance imaging scans from the MCSA (Mayo Clinic Study of Aging), a population-based study of residents 50 to 89 years of age in Olmsted County, Minnesota, were reviewed. Participants with imaging consistent with SS were identified from 2011 through 2016. An inverse probability weighting approach was used to convert our observed frequencies to population prevalence of SS. Additional data abstracted included amyloid positron emission tomography, Apolipoprotein E genotype, coexisting cerebral microbleeds, and extent of SS.

Results—

A total of 1412 participants had eligible magnetic resonance imaging scans. Two participants had infratentorial SS, restricted to the posterior fossa. Thirteen participants had cortical SS involving the cerebral convexities (7 focal and 6 disseminated). Only 3 of the participants with cortical SS (23%) also had cerebral microbleeds. The population prevalence of SS was 0.21% (95% confidence interval, 0–0.45) in those 50 to 69 years old and 1.43% (confidence interval, 0.53–2.34) in those over 69 years old. Apolipoprotein E ε2 allele was more common in those with SS (57.1% versus 15.0%;
P
<0.001). Compared with participants without SS, those with SS were also more likely to have a positive amyloid positron emission tomographic scan (76.9% versus 29.8%;
P
<0.001).

Conclusions—
SS may be encountered in the general elderly population. The association with increased amyloid burden and Apolipoprotein E ε2 genotype supports cerebral amyloid angiopathy as the most common mechanism. Longitudinal follow-up is needed to evaluate the risk of subsequent hemorrhage in cases of incidentally discovered SS.
On the Benefit of a Phenomenological Revision of Problem Solving
Authors: Wendt Alexander Nicolai 
Published: October 2017

AbstractProblem solving has been empirical psychology’s concern for half a century. Cognitive science’s work on this field has been stimulated especially by the computational theory of mind. As a result, most experimental research originates from a mechanistic approach that disregards genuine experience. On the occasion of a review of problem solving’s foundation, a phenomenological description offers fruitful perspectives. Yet, the mechanistic paradigm is currently dominant throughout problem solving’s established patterns of description. The review starts with a critical historical analysis of the state of problem solving in academic psychology. Subsequently, a phenomenological, contrastive approach is proposed. It questions the notion of problems as “goal-driven” behavior by making vivid experience the subject of discussion. As its given compounds, solvability, oppressiveness, and the problem’s horizon are discussed. Ultimately, an experience-based multimodal notion of the problem is elaborated that relates problems to challenges, fatalities and opportunities as different types of situations.
Public Theology and Interreligious Dialogue
Authors: Bedford-Strohm Heinrich 
Published: October 2017

Abstract
The article assesses the current intercultural and interreligious situation in Germany after the arrival of a great number of mostly Muslim refugees in 2015. It describes four approaches of interreligious dialogue and further explores the concept of Trinitarian Inclusivism. Among four different ways of defining the relationship between state and religion, the model of ‘Public Religion’ is seen as the most plausible social theoretical counterpart to such Trinitarian Inclusivism. John Rawls’ idea of an overlapping consensus provides the space for constructively exchanging strong religious or nonreligious truth claims in a lively pluralism. Finally, the article pleads for developing a public theology of the religions to contribute to the peacebuilding and reconciliatory task of the religions.
A Regime-Based Evaluation of TRMM Oceanic Precipitation Biases
Authors: Henderson David S. , Kummerow Christian D. , Marks David A. , Berg Wesley 
Published: October 2017

AbstractOver the tropical oceans, large discrepancies in TRMM passive and active microwave rainfall retrievals become apparent during El Niño–Southern Oscillation (ENSO) events. This manuscript describes the application of defined precipitation regimes to aid the validation of instantaneous rain rates from TRMM using the S-band radar located on the Kwajalein Atoll. Through the evaluation of multiple case studies, biases in rain-rate estimates from the TRMM radar (PR) and radiometer (TMI) are best explained when derived as a function of precipitation organization (e.g., isolated vs organized) and precipitation type (convective vs stratiform). When examining biases at a 1° × 1° scale, large underestimates in both TMI and PR rain rates are associated with predominately convective events in deep isolated regimes, where TMI and PR retrievals are underestimated by 37.8% and 23.4%, respectively. Further, a positive bias of 33.4% is observed in TMI rain rates within organized convective systems containing large stratiform regions. These findings were found to be consistent using additional analysis from the DYNAMO field campaign. When validating at the TMI footprint scale, TMI–PR differences are driven by stratiform rainfall variability in organized regimes; TMI overestimates this stratiform precipitation by 92.3%. Discrepancies between TMI and PR during El Niño events are related to a shift toward more organized convective systems and derived TRMM rain-rate bias estimates are able to explain 70% of TMI–PR differences during El Niño periods. An extension of the results to passive microwave retrievals reveals issues in discriminating convective and stratiform rainfall within the TMI field of view (FOV), and significant reductions in bias are found when convective fraction is constrained within the Bayesian retrieval.
Two-Year Stability and Change in Access to and Reasons for Lacking a Usual Source of Care Among Working-Age US Adults
Authors: Stransky Michelle L. 
Published: October 2017

Objective: The objective of this study was to investigate usual source of care (USC) over time. Methods: A nationally representative sample of working-age adults in the Medical Expenditure Panel Survey (Panels 16 [2011-2012] and 17 [2012-2013]) was divided into 3 groups based on USC questions asked during 2 waves: (1) those having a USC during both waves (always USC), (2) those not having a USC during either wave (never USC), and (3) those who gained or lost a USC between the 2 waves (changed USC). The study examined the sociodemographic and health characteristics associated with these groups and the main reasons for not having a USC among those who never had a USC and those who changed their USC. Results: Of the 10 792 adults in the analysis, a longitudinally weighted 18.8% reported that their USC changed during the period. Among adults in the changed USC group, those with private (odds ratio [OR] = 2.0, P = .001) or public (OR = 2.2, P = .001) health insurance and 1 (OR = 1.7, P = .04) or ≥2 (OR = 3.1, P = .02) chronic health conditions were more likely to transition to having a USC from not having a USC, compared with those who had no insurance and no chronic conditions. Compared with those in the changed USC group, those in the never USC group were more likely to report preferring not to have a USC (57.9% vs 80.1%, P < .001). Conclusions: Insurance and public health policies and programs are needed to reduce short-term changes in USC and increase the number of adults with ongoing, consistent USC.
Reducing Smoking in the US Federal Workforce: 5-Year Health and Economic Impacts From Improved Cardiovascular Disease Outcomes
Authors: Asay Garrett R. Beeler , Homa David M. , Abramsohn Erin M. , Xu Xin , O’Connor Erin L. , Wang Guijing 
Published: October 2017

Objective: We estimated the reduction in number of hospitalizations for acute myocardial infarction and stroke as well as the associated health care costs resulting from reducing the number of smokers in the US federal workforce during a 5-year period. Methods: We developed a 5-year spreadsheet-based cohort model with parameter values from past literature and analysis of national survey data. We obtained 2015 data on the federal workforce population from the US Office of Personnel Management and data on smoking prevalence among federal workers from the 2013-2015 National Health Interview Survey. We adjusted medical costs and productivity losses for inflation to 2015 US dollars, and we updated future productivity losses for growth. Because of uncertainty about the achievable reduction in smoking prevalence and input values (eg, relative risk for acute myocardial infarction and stroke, medical costs, and absenteeism), we performed a Monte Carlo simulation and sensitivity analysis. Results: We estimated smoking prevalence in the federal workforce to be 13%. A 5 percentage-point reduction in smoking prevalence could result in 1106 fewer hospitalizations for acute myocardial infarction (range, 925-1293), 799 fewer hospitalizations for stroke (range, 530-1091), and 493 fewer deaths (range, 494-598) during a 5-year period. Similarly, estimated costs averted would be $59 million (range, $49-$63 million) for medical costs, $332 million (range, $173-$490 million) for absenteeism, and $117 million (range, $93-$142 million) for productivity. Conclusion: Reductions in the prevalence of smoking in the federal workforce could substantially reduce the number of hospitalizations for acute myocardial infarction and stroke, lower medical costs, and improve productivity.
Matthew Flinders Senior (1751–1802): Surgeon and ‘man midwife’
Authors: Shields Linda , Jomeen Julie , Smyth Wendy , Stanley David 
Published: October 2017

Until the eighteenth century, midwifery was the sole domain of women, but changes in medical science saw it appropriated by medical men and the ‘man-midwife’ emerged. This paper demonstrates the work of a man-midwife in a small English village in one year, 1775, using his accounts and correspondence. The man was Matthew Flinders Senior, ‘surgeon and man-midwife’ at Donington, Lincolnshire. He was the father of Captain Matthew Flinders, the famous navigator who mapped the coast line of Australia and who coined that name. Primary sources, published as a collection by the Lincoln Record Society, were used. Flinders Senior made a good living from his midwifery, charging rates commensurate with those charged by obstetricians today (with reduced costs for the poor). His descriptions of his practice show how midwifery was conducted in rural England during the development of medicine as a high-status profession. The paper uses data from one year to provide a snap shot of the work of a rural surgeon and man-midwife, but much more is available in the published collection, providing ready access for researchers who may like to pursue such work further.
Ferritin is secreted via 2 distinct nonclassical vesicular pathways
Authors: Truman-Rosentsvit Marianna , Berenbaum Dina , Spektor Lior , Cohen Lyora A. , Belizowsky-Moshe Shirly , Lifshitz Lena , Ma Jing , Li Wei , Kesselman Ellina , Abutbul-Ionita Inbal , Danino Dganit , Gutierrez Lucia , Li Huihui , Li Kuanyu , Lou Huifang , Regoni Maria , Poli Maura , Glaser Fabian , Rouault Tracey A. , Meyron-Holtz Esther G. 
Published: October 2017

Key Points
Iron-loaded ferritin is secreted via both the nonclassical secretory autophagy and multivesicular body–exosome pathways. A motif on both ferritin subunits is involved in the regulation of ferritin secretion.
Prevalence, impact and care of foot problems in people with rheumatoid arthritis: results from a United Kingdom based cross‐sectional survey
Authors: Wilson Oonagh , Hewlett Sarah , Woodburn James , Pollock Jon , Kirwan John 
Published: October 2017

AbstractBackgroundFoot symptoms in rheumatoid arthritis (RA) derive from a combination of inflammation, altered foot mechanics, deformity and secondary skin lesions. Guidelines recommend regular review of patients' feet, but the extent to which the general population of RA patients report foot symptoms and access foot care has not been established. The aims of this study were to determine the prevalence, impact and care of foot problems in all patients with RA in one geographical area and identify factors associated with accessing foot care.MethodsCross‐sectional survey of a random sample of patients with RA, who resided within a single community‐based National Health Service (NHS) podiatry service. The questionnaire collected demographic data (age, gender, local deprivation score), clinical data (disease duration, arthritis medications, disability (Health Assessment Questionnaire (HAQ)), current foot problems, foot care accessed (podiatry, orthotics and/or orthopaedics) and care received, measures of impact (Foot Impact Scale) and ability to work.ResultsOf 1003 total eligible patients in the target population, 739 were posted survey packs. Of these 413 (56%) replied. Responders and non‐responders had similar age (63.5 yr. vs.61.5 yr), gender (74.1%F vs. 75.2%F), and highest deprivation category (13.3% vs.15.9%). Of the responders 92.1% reported current foot problems: articular 73.8%, cutaneous lesions 65.4%, structural 57.6%, extra‐articular 42.6%. Responders' median (IQR) disease duration 10 (5–20) years, HAQ 1.5 (0.75–2.0), FISIF 10 (6–14) and FISAP 16 (7–23) and 37.8% reported impacts on work. While 69.5% had accessed foot care there were differences in the route of access (by gender and whether independent or NHS provision) and were older (64.9 yr. vs 60.4 yr. p = 0.001), had longer disease duration (12 yr. vs 7 yr. p < 0.001) and had a greater proportion of females (72.2% vs 61.7% p = 0.04) than those who had not accessed care.ConclusionsCurrent foot problems were reported by 92.1% of the study sample and substantially impacted on life and work. While overall access to foot care was higher than anticipated, routes of access differed and extent of current problems suggests the provision of effective, timely and targeted care is a pressing need.
Achieving community-based postpartum follow up in eastern Uganda: the field experience from the MamaMiso Study on antenatal distribution of misoprostol
Authors: Ditai James , Frye Laura J. , Durocher Jill , Byrne Meagan E. , Ononge Sam , Winikoff Beverly , Weeks Andrew D. 
Published: October 2017

Abstract
Background
Advance provision of misoprostol to women during antenatal care aims to achieve broader access to uterotonics for the prevention of postpartum hemorrhage. Studies of this community-based approach usually involve antenatal education as well as timely postpartum follow-up visits to confirm maternal and neonatal outcomes. The MamaMiso study in Mbale, Uganda sought to assess the feasibility of conducting follow-up visits in the postpartum period following advance provision of misoprostol for postpartum hemorrhage prevention. MamaMiso recruited women during antenatal care visits. Participants were asked to contact the research team within 48 h of giving birth so that postpartum follow-up visits could be carried out at their homes. Women’s baseline and delivery characteristics were collected and analyzed with respect to follow-up time (‘on time’ ≤ 7 days, ‘late’ > 7 days, and ‘lost to follow up’). Every woman who was followed up late due to a failure to report the delivery was asked for the underlying reasons for the delay. When attempts at following up participants were unsuccessful, a file note was generated explaining the details of the failure. We abstracted data and identified themes from these notes.

Results
Of 748 recruited women, 700 (94%) were successfully followed up during the study period, 465 (62%) within the first week postpartum. The median time to follow up was 4 days and was similar for women who delivered at home or in facilities and for women who had attended or unattended births. Women recruited at the urban hospital site (as opposed to rural health clinics) were more likely to be lost to follow up or followed up late. Of the women followed up late, 202 provided a reason. File notes explaining failed attempts at follow up were generated for 164 participants. Several themes emerged from qualitative analysis of these notes including phone difficulties, inaccurate baseline information, misperceptions, postpartum travel, and the condition of the mother and neonate.

Conclusions
Keeping women connected to the health system in the postpartum period is feasible, though reaching them within the first week of their delivery is challenging. Understanding characteristics of women who are harder to reach can help tailor follow-up efforts and elucidate possible biases in postpartum study data.
Trial Registration Number ISRCTN70408620 December 28, 2011