bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expansion of Umbilical Cord Blood Aldehyde Dehydrogenase Expressing Cells Generates Myeloid Progenitor Cells that Stimulate Limb Revascularization
Authors: Putman David M. , Cooper Tyler T. , Sherman Stephen E. , Seneviratne Ayesh K. , Hewitt Mark , Bell Gillian I. , Hess David A. 
Published: June 2017

Abstract
Uncompromised by chronic disease-related comorbidities, human umbilical cord blood (UCB) progenitor cells with high aldehyde dehydrogenase activity (ALDHhi cells) stimulate blood vessel regeneration after intra-muscular transplantation. However, implementation of cellular therapies using UCB ALDHhi cells for critical limb ischemia, the most severe form of severe peripheral artery disease, is limited by the rarity (&lt;0.5%) of these cells. Our goal was to generate a clinically-translatable, allogeneic cell population for vessel regenerative therapies, via ex vivo expansion of UCB ALDHhi cells without loss of pro-angiogenic potency. Purified UCB ALDHhi cells were expanded &gt;18-fold over 6-days under serum-free conditions. Consistent with the concept that ALDH-activity is decreased as progenitor cells differentiate, only 15.1% ± 1.3% of progeny maintained high ALDH-activity after culture. However, compared to fresh UCB cells, expansion increased the total number of ALDHhi cells (2.7-fold), CD34+/CD133+ cells (2.8-fold), and hematopoietic colony forming cells (7.7-fold). Remarkably, injection of expanded progeny accelerated recovery of perfusion and improved limb usage in immunodeficient mice with femoral artery ligation-induced limb ischemia. At 7 or 28 days post-transplantation, mice transplanted with expanded ALDHhi cells showed augmented endothelial cell proliferation and increased capillary density compared to controls. Expanded cells maintained pro-angiogenic mRNA expression and secreted angiogenesis-associated growth factors, chemokines, and matrix modifying proteins. Coculture with expanded cells augmented human microvascular endothelial cell survival and tubule formation under serum-starved, growth factor-reduced conditions. Expanded UCB-derived ALDHhi cells represent an alternative to autologous bone marrow as an accessible source of pro-angiogenic hematopoietic progenitor cells for the refinement of vascular regeneration-inductive therapies.
Retrospective Study of the Correlation Between Pathological Tumor Size and Survival After Curative Resection of T3 Pancreatic Adenocarcinoma: Proposal for Reclassification of the Tumor Extending Beyond the Pancreas Based on Tumor Size
Authors: Kurata Masanao , Honda Goro , Murakami Yoshiaki , Uemura Kenichiro , Satoi Sohei , Motoi Fuyuhiko , Sho Masayuki , Matsumoto Ippei , Kawai Manabu , Yanagimoto Hiroaki , Fukumoto Takumi , Nagai Minako , Gosho Masahiko , Unno Michiaki , Yamaue Hiroki ,   for the Multicenter Study Group of Pancreatobiliary Surgery (MSG‐PBS)
Published: June 2017

AbstractBackgroundEven though most patients who undergo resection of pancreatic adenocarcinoma have T3 disease with extra‐pancreatic tumor extension, T3 disease is not currently classified by tumor size. The aim of this study was to modify the current TNM classification of pancreatic adenocarcinoma to reflect the influence of tumor size.MethodsA total of 847 consecutive pancreatectomy patients were recruited from multiple centers. Optimum tumor size cutoff values were calculated by receiver operating characteristics analysis for tumors limited to the pancreas (T1/2) and for T3 tumors. In our modified TNM classification, stage II was divided into stages IIA (T3aN0M0), IIB (T3bN0M0), and IIC (T1‐3bN1M0) using tumor size cutoff values. The usefulness of the new classification was compared with that of the current classification using Akaike’s information criterion (AIC).ResultsThe optimum tumor size cutoff value distinguishing T1 and T2 was 2 cm, while T3 was divided into T3a and T3b at a tumor size of 3 cm. The median survival time of the stages IIA, IIB, and IIC were 44.7, 27.6, and 20.3 months, respectively. There were significant differences of survival between stages IIA and IIB (P = 0.02) and between stages IIB and IIC (P = 0.03). The new classification showed better performance compared with the current classification based on the AIC value.ConclusionsThis proposed new TNM classification reflects the influence of tumor size in patients with extra‐pancreatic tumor extension (T3 disease), and the classification is useful for predicting mortality.
Impact of premix antimicrobial preparation and time to administration in septic patients
Authors: Kufel Wesley D. , Seabury Robert W. , Meola Gregory M. , Darko William , Probst Luke A. , Miller Christopher D. 
Published: June 2017

ABSTRACTObjectiveStrategies that reduce the time to antimicrobial administration, such as the availability of premix antimicrobials (PMAs) in the emergency department (ED), may better align with the goals of the Surviving Sepsis Campaign and improve outcomes in septic patients. The objective of this study was to evaluate the impact of antimicrobial preparation on time to administration in septic patients located in the emergency department (ED).MethodsThis was a retrospective, single-center, cohort study and adult patients with a diagnosis of sepsis who received at least one initial intravenous (IV) antimicrobial in the ED were included. Time to complete an empiric antimicrobial therapy was defined as the time between prescriber order entry and the infusion initiation time of the final antimicrobial agent of a patient’s antimicrobial regimen. Appropriate, empiric antimicrobial therapy was based on treatment recommendations by nationally accepted guidelines for the specific indication.ResultsThe first antimicrobial was initiated earlier when available as a PMA preparation (median (IQR): premix 25 minutes (16.5-42.3) vs. non-premix 46 minutes (20-102), p=0.027). When comparing complete, empiric antimicrobial regimen administration, there was no difference in time to administration between regimens containing one or more non-premix antimicrobials and regimens containing all PMAs (median (IQR): premix 69 minutes (21-115) vs. non-premix 65 minutes (38.5-133.8); p=0.455).ConclusionsPMA preparations significantly reduced time to administration of the first antimicrobial agent for septic patients treated in the ED, but time to administration of subsequent antimicrobials were not improved.
Healthcare Antibiotic Resistance Prevalence – DC (HARP-DC): A Regional Prevalence Assessment of Carbapenem-Resistant Enterobacteriaceae (CRE) in Healthcare Facilities in Washington, District of Columbia
Authors: Reuben Jacqueline , Donegan Nancy , Wortmann Glenn , DeBiasi Roberta , Song Xiaoyan , Kumar Princy , McFadden Mary , Clagon Sylvia , Mirdamadi Janet , White Diane , Harris Jo Ellen , Browne Angella , Hooker Jane , Yochelson Michael , Walker Milena , Little Gary , Jernigan Gail , Hansen Kathleen , Dockery Brenda , Sinatro Brendan , Blaylock Morris , Harmon Kimary , Iyengar Preetha , Wagner Trevor , Nelson Jo Anne ,   HARP Study Team
Published: June 2017

OBJECTIVECarbapenem-resistant Enterobacteriaceae (CRE) are a significant clinical and public health concern. Understanding the distribution of CRE colonization and developing a coordinated approach are key components of control efforts. The prevalence of CRE in the District of Columbia is unknown. We sought to determine the CRE colonization prevalence within healthcare facilities (HCFs) in the District of Columbia using a collaborative, regional approach.DESIGNPoint-prevalence study.SETTINGThis study included 16 HCFs in the District of Columbia: all 8 acute-care hospitals (ACHs), 5 of 19 skilled nursing facilities, 2 (both) long-term acute-care facilities, and 1 (the sole) inpatient rehabilitation facility.PATIENTSInpatients on all units excluding psychiatry and obstetrics-gynecology.METHODSCRE identification was performed on perianal swab samples using real-time polymerase chain reaction, culture, and antimicrobial susceptibility testing (AST). Prevalence was calculated by facility and unit type as the number of patients with a positive result divided by the total number tested. Prevalence ratios were compared using the Poisson distribution.RESULTSOf 1,022 completed tests, 53 samples tested positive for CRE, yielding a prevalence of 5.2% (95% CI, 3.9%–6.8%). Of 726 tests from ACHs, 36 (5.0%; 95% CI, 3.5%–6.9%) were positive. Of 244 tests from long-term-care facilities, 17 (7.0%; 95% CI, 4.1%–11.2%) were positive. The relative prevalence ratios by facility type were 0.9 (95% CI, 0.5–1.5) and 1.5 (95% CI, 0.9–2.6), respectively. No CRE were identified from the inpatient rehabilitation facility.CONCLUSIONA baseline CRE prevalence was established, revealing endemicity across healthcare settings in the District of Columbia. Our study establishes a framework for interfacility collaboration to reduce CRE transmission and infection.Infect Control Hosp Epidemiol 2017;38:921–929
Service users’ experiences of mental health tribunals in Ireland: a qualitative analysis
Authors: Murphy R. , McGuinness D. , Bainbridge E. , Brosnan L. , Keys M. , Felzmann H. , Murphy K. , Hallahan B. , Higgins A. , McDonald C. 
Published: June 2017

ObjectivesTo explore the mental health tribunal experiences of people admitted involuntarily under the Mental Health Act 2001.MethodsEmploying a qualitative descriptive study design, data were collected from 23 service users who had experienced mental health tribunals during a recent involuntary admission. Face-to-face semi-structured interviews were conducted ~3 months post-revocation of their involuntary admission order. Data were analysed using an inductive thematic process.ResultsThe majority of participants reported mixed experiences comprising positive and negative aspects in relation to information provision, emotional support and an inclusive atmosphere. Some participants reported receiving accessible information about the tribunal process, felt emotionally supported throughout, and encountered respectful and dignifying practices during the tribunal proceedings. However, many participants described experiencing non-inclusive practices, reported feeling ill-informed regarding the tribunal process, emotionally unsupported during and after the tribunal, and distressed by what they perceived as adversarial tribunal proceedings.ConclusionsSystemic changes could ensure that the positive experiences encountered by the minority of participants in this study are more consistently experienced. Ongoing education and training of stakeholders in the provision of inclusive tribunal practices, and the provision of accessible information and emotional support to service users through the stages of the involuntary admission process appear likely to be beneficial. Service users should automatically be offered the option of having a support person of their choosing present during tribunals.
Multivariate and conditioned statistics of velocity and wall pressure fluctuations induced by a jet interacting with a flat plate
Authors: Mancinelli Matteo , Di Marco Alessandro , Camussi Roberto 
Published: June 2017

The increasing size of aircraft engines is leading to reconsideration of their conventional integration in the under-wing configuration due to the strong interaction between the jet and the airframe components. As a consequence, more insight is needed into the complex mechanisms underlying the interaction phenomenon between the jet flow and a surface. The objective of this paper is to carry out a series of experimental tests on a simplified laboratory-scale model to approach/deepen the problem. This analysis is the continuation of a previous study (Di Marco et al., J. Fluid Mech., vol. 770, 2015, pp. 247–272) on a rigid flat plate installed tangentially to the axis of an incompressible jet. In the present work, the velocity and wall pressure fields were simultaneously measured for different radial distances of the plate from the nozzle axis. Pointwise hot-wire anemometer measurements were carried out to characterize the effect of the plate on the velocity field statistics up to the fourth-order moment. The analysis revealed that the presence of the plate brings about a deflection of the mean aerodynamic field over the surface and a reduction of the turbulence intensity. Wall pressure fluctuations induced by the jet flow over the plate were measured by a linear array of cavity-mounted microphones placed along the streamwise direction. The velocity/pressure cross-statistics are achieved in the time and frequency domains using cross-correlations and Fourier analysis. A wavelet-based conditional sampling procedure is applied as well to characterize the flow signatures related to the velocity and wall pressure fluctuations, revealing that the surface induces the breakdown of the large-scale turbulent structures. The dependence of the multivariate and conditioned statistics on the plate distance from the jet as well as on the streamwise and crosswise probe positions is extensively discussed. Different organized flow motions over the surface are found based on the wall pressure events detected. A scaling criterion for velocity signatures is also presented addressing the governing parameters of the jet–plate interaction phenomenon.
Expressing harmonic sums as fractions
Authors: Jameson G. J. O. 
Published: June 2017

As usual, writeIn [1], it is shown, by an elegant method, that for all n ⩾ 2, Hn is not an integer. The method can be traced back at least to [2, Exercise 251, p. 159]. Actually, rather more is shown: if Hn is expressed as a fraction an/bn in its lowest terms, then for all n ⩾ 2, bn is even. One way of looking at this is to say that once the term has entered the sum, the factor 2 persists in the denominator from then on. This suggests the following question:(Q1) for primes p ⩾ 3, is bn a multiple of p for all n ⩾ p?and more generally:(Q2) for any prime p, is bn a multiple of pm for all n ⩾ pm?In other words, once 1/pm has entered the sum, does the factor pm persist in the denominator?Let dn denote the lowest common multiple of 1, 2, … , n. This number can be described as follows: for each prime p ⩽ n, let mp be the largest integer m such that pm ⩽ n. Then . Hence a positive answer to (Q2) would imply that bn simply equals dn.
Some alternative derivations of Craig's formula
Authors: Stewart Seán M. 
Published: June 2017

In the performance of digital communication systems over fading channels, the error analysis is typically modelled using a Gaussian probability distribution. One function central to the analysis is what engineers routinely refer to as the (Gaussian) Q-function and is defined by1This is the canonical representation used for the function. In this paper a number of derivations of an important alternative representation for the Q-function known as Craig's formula will be given.
Radiocarbon Ecology of the Land Snail Helix Melanostoma in Northeastern Libya
Authors: Hill E A , Reimer P J , Hunt C O , Prendergast A L , Barker G W 
Published: June 2017

AbstractTerrestrial gastropods are problematical for radiocarbon (14C) measurement because they tend to incorporate carbon from ancient sources as a result of their dietary behavior. The 14C ecology of the pulmonate land snail, Helix melanostoma in Cyrenaica, northeastern Libya, was investigated as part of a wider study on the potential of using terrestrial mollusk shell for 14C dating of archaeological deposits. H. melanostoma was selected out of the species available in the region as it has the most predictable 14C ecology and also had a ubiquitous presence within the local archaeology. The ecological observations indicate that H. melanostoma has a very homogenous 14C ecology with consistent variations in F14C across sample sites controlled by availability of dietary vegetation. The majority of dated specimens from non-urbanized sample locations have only a small old-carbon effect, weighted mean of 476±48 14C yr, with between ~1% and 9% of dietary F14C from non-organic carbonate sources. Observed instabilities in the 14C ecology can all be attributed to the results of intense human activity not present before the Roman Period. Therefore, H. melanostoma and species with similar ecological behavior are suitable for 14C dating of archaeological and geological deposits with the use of a suitable offset.
Community-wide stable isotope analysis reveals two distinct trophic groups in a service-providing carabid community
Authors: Kamenova S. , Leroux C. , Polin S.E. , Plantegenest M. 
Published: June 2017

AbstractDisentangling trophic interactions among species is important for elucidating mechanisms underlying ecosystem functioning and services. Carabid beetles are an important guild of predators that may regulate pest populations in arable landscapes, but their generalist feeding behavior hinders predictions about their actual contribution to pest control. In order to assess carabids’ potential for pest control, we simultaneously analyzed the carbon and nitrogen stable isotope ratios of a community of 45 co-occurring species in wheat and oilseed rape fields. With the expectation to identify distinct trophic groups based on the mean and the variance of carabid isotopic signatures, we observed a high degree of overlap in trophic positions between species. However, we also observed that species could be successfully categorized into two groups according to whether or not their carbon signatures varied independently from variations in the crop baseline. We interpret these results as differential primary resource uptake or by differential mobility aptitude in foraging. Accordingly, we propose that the isotopic signal can inform us on the presence/absence of links between generalist predators and cultivated plants through the trophic networks they belong to, and consequently on their potential role as pest natural enemies. We therefore suggest the complementarity of stable isotope analysis for obtaining a time-integrated assessment of carabid trophic behavior that may be combined with more direct molecular diet analysis allowing the simultaneous quantification of specific trophic links within agricultural landscapes.
LITIGATING INDIGENOUS PEOPLES’ RIGHTS IN AFRICA: POTENTIALS, CHALLENGES AND LIMITATIONS
Authors: Gilbert Jérémie 
Published: June 2017

AbstractAdopting a comparative analysis, this article examines some recent litigation which has focused on indigenous peoples’ rights across the African continent. The aim is to explore both the potential and the challenges and limitations of litigation as a tool for supporting the rights of indigenous peoples. The article explores the extent to which a specific African jurisprudence is emerging on issues that are essential to indigenous peoples such as non-discrimination, self-identification, land rights and development. It also focuses on the practical issues that arise when engaging with litigation in order to explore the extent to which litigation can contribute to the legal empowerment of some of the most marginalized indigenous communities in Africa.
DIFFERENTIAL RESPONSES IN FIRST BIRTH BEHAVIOUR TO ECONOMIC RECESSION IN THE UNITED KINGDOM
Authors: Lyons-Amos Mark , Schoon Ingrid 
Published: June 2017

SummaryEconomic conditions have dramatic influences on fertility. This paper evaluates the effect of the 2008 ‘Great Recession’ in the UK on first birth rate, which is the fertility behaviour most susceptible to external economic conditions. The key aim of the study was to assess the effect of the recession on fertility by individual-level characteristics, enabling variation in responses to economic hardship to be observed. Data were from the nationally representative UK Household Longitudinal Study (UK-HLS). Cumulative transition models were used to model the probability of first birth for women between the ages of 17 and 30 in three UK birth cohorts. The effect of the recession was captured using direct measures (local unemployment rates and individual unemployment status) and a pre-/post-comparison, capturing indirect effects. In general, higher birth rates were observed among more disadvantaged women compared with advantaged groups. The effect of the recession was disaggregated by social strata; the overall effect was counter-cyclical although at a slower rate among disadvantaged women.
Market Penetration, Institutional Niches and Job Searches in Reforming China
Authors: Huang Xianbi 
Published: June 2017

AbstractUsing an institutional perspective, this paper explores coexisting job search methods in reforming China. Analysis of the 2003 Chinese General Social Survey data shows that China's labour markets are segmented into institutional niches by two key factors: the type of ownership of work organization and the status of the work organization in the market. The effectiveness of job search methods varies across the different institutional niches. Hierarchical arrangements and social networks remain powerful means of obtaining jobs in the state sector, including both monopolistic and competitive work organizations, while job searches using a market-oriented method are comparatively useful for winning jobs in the non-state sector irrespective of whether organizations are competitive or monopolistic in terms of market competition. This paper not only illustrates the value of an institutional approach to labour market research but also reveals the scope of market penetration in China's emerging labour markets.
The epidemiology of invasive pneumococcal disease in older adults in the post-PCV era. Has there been a herd effect?
Authors: CORCORAN M. , VICKERS I. , MERECKIENE J. , MURCHAN S. , COTTER S. , FITZGERALD M. , MCELLIGOTT M. , CAFFERKEY M. , O'FLANAGAN D. , CUNNEY R. , HUMPHREYS H. 
Published: June 2017

SUMMARYThe 7 and 13-valent pneumococcal conjugate vaccines (PCVs) have reduced the incidence of invasive pneumococcal disease (IPD) in children in many countries. The objective of this work was to assess the impact of PCVs and potential herd-protection in older adults in Ireland. IPD notification and typing data from adults ⩾65 years of age from July 2007 to June 2016 was assessed using national surveillance data. There was a 94% reduction in PCV7 serotypes from 2007–2008 to 2015–2016, incidence rate ratio (IRR 0·05, P < 0·0001). However, there was no decline in the additional PCV13 (PCV13-7) serotypes over the same period (IRR 0·90) nor in comparison with the pre-PCV13 period 2009–2010 (IRR 0·92). The incidence of serotypes in the 23-valent pneumococcal polysaccharide vaccine only (PPV23-PCV13) and non-vaccine types (NVTs) increased significantly (IRR 2·17, P = 0·0002 and IRR 3·43, P = 0·0001 respectively). Consequently, the overall IPD incidence rate in adults has remained relatively unchanged (from 28·66/100 000 to 28·88/100 000, IRR 1·01, P = 0·9477). Serotype 19A and NVTs were mainly responsible for penicillin resistance in recent years. The decline of PCV7 serotypes indicate that the introduction of PCV7 resulted in herd-protection for adults. However, increases in PPV23-PCV13 and NVTs suggest that changes in vaccination strategy amongst older adults are needed to build on the success of PCVs in children.
Down syndrome and transposition of the great arteries
Authors: McCrossan Brian , McCay Nicola 
Published: June 2017

AbstractThere is an old adage in paediatric cardiology that, despite the high prevalence and wide spectrum of CHD, transposition of the great arteries does not occur in trisomy 21. We present a case of transposition of the great arteries, ventricular septal defect, and pulmonary stenosis in a patient with trisomy 21.