bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carvacrol Ameliorates Ligation‐Induced Periodontitis in Rats
Authors: Kuo Po‐Jan , Hung Tsung‐Fu , Lin Chi‐Yu , Hsiao Hsiang‐Yin , Fu Min‐Wen , Hong Po‐Da , Chiu Hsien‐Chung , Fu Earl 
Published: April 2017

Background: This study aims to evaluate the ameliorative effect of carvacrol, an anti‐inflammatory monoterpenoid phenol and a major component of Plectranthus amboinicus, on periodontal damage in an experimental rat model of periodontitis.Methods: Forty Sprague‐Dawley rats were divided into ligation (Lig), non‐ligation (n‐Lig), and two ligation plus carvacrol (Lig+C) groups. Carvacrol (17.5 or 35.0 mg/kg body weight/day) was administered intragastrically from 1 day before ligation. On day 8, dental alveolar bone loss and gingival inflammation in periodontal specimens were examined by dental radiography, microcomputed tomography, and histology. Expressions of tumor necrosis factor‐α, interleukin (IL)‐1β, IL‐6, and inducible nitric oxide synthase messenger (m)RNAs, and levels of matrix metalloproteinase (MMP)‐2 and MMP‐9 in gingiva were examined by reverse transcription‐polymerase chain reaction and zymography.Results: Dental radiography revealed periodontal bone‐supporting ratios in Lig and Lig+C groups were lower than the n‐Lig group, with Lig group ratios being lowest. Compared with the n‐Lig group, the cemento‐enamel junction–bone distance was significantly longer in Lig and Lig+C groups, with Lig+C groups showing shorter distances regardless of radiographic methods used. Histology and histometry showed less inflammatory area and stronger connective tissue attachment in Lig+C groups than in the Lig group. Cytokine/mediator mRNA expression and MMP‐9 levels were reduced in the Lig+C groups.Conclusions: Carvacrol reduced tissue damage and bone loss caused by ligation‐induced periodontitis. The present results indicate that carvacrol might reduce tissue destruction by downregulating expression of proinflammatory mediators and MMP‐9.
The association of the IL-1β-31 polymorphism and the development of neuroinfections
Authors: Biesiada Grażyna , Czepiel Jacek , Piątek Anna , Birczyńska Malwina , Żurańska Justyna , Wołkow Paweł , Perucki William , Jędrychowski Michał , Garlicki Aleskander 
Published: April 2017

Introduction. Inflammation of the meninges can have various clinical courses, from mild, self‑limiting in some viral neuroinfections to severe, sometimes ending in death. The pro‑inflammatory cascade and defects in the inhibitors of the inflammatory response play an important prognostic role. Single nucleotide polymorphisms (SNPs) of the genes encoding cytokines, influence the severity of the inflammatory response.Aim. The aim of this study was to evaluate the effect of selected polymorphisms of proinflammatory cytokines IL-1β, TNF‑α and IL-8 on the development of neuroinfections.Material and Methods. We evaluated the laboratory results of 30 patients treated for bacterial and viral meningitis and compared those to 30 healthy volunteers. The following 4 variants were analyzed for occurrence of genetic polymorphism in patients with meningitis versus the control group: IL-1β 3953, IL-1β -31, TNF‑α -308, and IL-8 781. Then, we assessed the association between these genetic polymorphisms and the inflammatory response during the course of meningitis.Results and Conclusions. We observed that polymorphism of the IL-1β-31 significantly differs between patients and healthy subjects, the IL-1β -31AA polymorphism existed only in healthy individuals (p < 0.001). The WBC count was dependent on the TNF‑α -308 polymorphism with a statistically significant difference (p = 0.021) occurring among persons with variants AA and AG. In conclusion the study showed that the presence of the AA genotype of IL-1β-31polymorphism may have a protective effect on the development of meningitis. This polymorphism was not observed in any patient with meningitis.
Ischemia‑modified albumin in migraine patients during interictal period
Authors: Michalak Slawomir , Osztynowicz Krystyna , Płóciniczak Alicja , Myszka Waldemar , Nowicki Marcin , Węgrzyn Danuta , Drzewiecka Małgorzata , Kapecka Kinga , Kozubski Wojciech 
Published: April 2017

Aim. Ischemia‑modified albumin (IMA) is a marker of myocardial ischemia and may be affected by ischemia occurring in other tissues. Migraine has been reported as a risk factor of ischemic stroke or cardiovascular events. Dysfunction of endothelial cells, as well as association with arteriopathies was evidenced in migraine patients. The aim of this study was to evaluate interictal IMA in migraine patients.Material and Methods. Fifty migraineurs aged 38 ± 9 years were included in the study. The control group consisted of 25 healthy volunteers aged 37 ± 8 years. In all subjects neurological examination was carried on, as well as clinimetric evaluation with the use of: MIDAS, MIGSEV, QVM, VAS and VRS. Ischemia‑modified albumin was evaluated by means of spectrophotometric method with the use of cobalt chloride. The concentrations of total cholesterol, HDL- and LDL‑cholesterol, triglycerides, homocysteine, C‑reactive protein and Lp(a) were analyzed with routine spectrophotometric methods.Results. IMA was significantly (P = 0.0108) higher in migraine patients (0.101; 0.00–0.327 O.D.) than in controls (0.00; 0.00–0.102 O.D.; median; interquartile range). Migraineurs with aura have also higher IMA than controls. IMA correlated (rS = 0.383, P = 0.0073) with VAS and with homocysteine concentration (rS = 0.430, P = 0.0026). Multiple regression analysis of IMA and atherosclerosis risk factors showed significant correlation (P = 0.0247) with HDL cholesterol (R = 0.2958) and triglycerides concentrations (R = 0.3285).Conclusions. IMA formation in migraine patients, as a marker of oxidative stress even during interictal period in patients with hyperhomocysteinemia and/or hypertriacylglyceridemia can reflect a milieu of factors which further increases the risk for cardiovascular complications.
Perspectives for gallotannins neuroprotective potential - current experimental evidences
Authors: Kujawski Radosław , Kujawska Małgorzata , Ożarowski Marcin , Baraniak Justyna , Laskowska Halina , Nowocień Tamara , Borowska Magdalena , Szulc Michał , Sobczak Agnieszka , Mikołajczak Przemysław 
Published: April 2017

Gallotannins are class of hydrolyzable tannins consisting of gallic acid and a sugar moiety. Currently, there is growing interest around a possible neuroprotective effect of this class of phytochemicals, which is suggested to be a result of their active metabolites. Evidence from experimental studies has suggested that tannin‑rich plant preparations might be effective at reversing neurodegenerative pathology and age‑related declines in neurocognitive performance. This mini‑review summarizes, based on experimental studies, current knowledge about diverse neuroprotective abilities of gallotannins, mostly via antioxidant properties and some mechanisms of the effect are proposed including blocking accumulation of nitrites, inhibiting expression and activity of heme oxygenase 1(HO-1), and decreasing degradation of poly(ADP‑ribose) glycohydrolase (PARP).
A study of ofloxacin and levofloxacin photostability in aqueous solutions
Authors: Frąckowiak Anita , Kamiński Bartosz , Urbaniak Bartosz , Dereziński Paweł , Klupczyńska Agnieszka , Darul‑Duszkiewicz Monika , Kokot Zenon J. 
Published: April 2017

Introduction. The photostability is one of the most important properties of drugs. A comprehensive study of ofloxacin (OFX) and levofloxacin (LVX) photostability in aqueous solutions was performed. Ofloxacin is a chemotherapeutic agent belonging to the second generation fluoroquinolones and is a racemate of (R)-(+)-ofloxacin and (S)-(-)-ofloxacin (LVX).Material and Methods. Samples of OFX and LVX were subjected to stress conditions of UV irradiation using a mercury‑vapor lamp. The study involved development of enantioselective high‑performance liquid chromatography (HPLC) and high‑performance capillary electrophoresis (HPCE) methods for separation of OFX enantiomers and their degradation products. These methods were used to monitor the degradation process of OFX and LVX under irradiation and to determine the kinetics of degradation of these antibacterial agents. Moreover, the identification of photoproducts was also attempted. The structure of the main photoproducts was examined by mass spectrometry (MS).Results and Conclusions. Using HPLC method it was possible to observe two products of OFX degradation and only one for LVX, while using HPCE method eight products of OFX degradation and six of LVX were observed. Some of the photoproducts retain character of optically active compounds. The trend of the photodegradation of both tested compounds was described by autocatalytic reaction proceeding according to the Prout‑Tompkins model. Some of the products of the decomposition catalyze this reaction. The rate of degradation was similar for both enantiomers but t0.5 was slightly longer for LVX than OFX. Based on MS experiments the photodegradation products of the studied fluoroquinolones and possible pathways of UV induced decay were identified.
Proteomic and metabolomic strategy of searching for biomarkers of genital cancer diseases using mass spectrometry methods
Authors: Matysiak Jan , Dereziński Paweł , Klupczyńska Agnieszka , Hajduk Joanna , Światły Agata , Plewa Szymon , Horała Agnieszka , Jaźwiński Patryk , Banach Paulina , Nowak-Markwitz Ewa , Kokot Zenon J. 
Published: April 2017

The project entitled ”Proteomic and metabolomic strategy of searching for biomarkers of genital cancer diseases using mass spectrometry methods” is a study based on novel omics techniques. The main assumption of this research is the development of innovative model of searching of biomarkers in ovarian and prostate cancers using proteomics and metabolomics methodologies supported by bioinformatics analysis. The innovatory strategy based on the latest achievements in the field of mass spectrometry will allow for the implementation of the unique studies for discovery new biomarkers, which are useful in prediction, diagnosis and treatment of the genital cancers. To date, there is no comprehensive data including set of proteins and other endogenous compounds involved in the development and differentiation of these diseases. Therefore, the proposed approach may contribute to the discovery of biomarkers with high sensitivity and specificity, which will provide new information about genital cancers characterization.
Can a healthcare worker be a source of an infection of a patient – a risk of transmitting the chickenpox and shingles virus VZV by the staff of hospital wards – preliminary research findings.
Authors: Stryczyńska-Kazubska Joanna , Małecka Ilona , Biskupska Maria , Bilski Bartosz , Pietrzycka Dorota , Wysocki Jacek 
Published: April 2017

Introduction. Chickenpox is a highly infectious disease, caused by the Varicella-zoster virus. An infection during pregnancy poses particular risk, as it may have serious consequences for both the pregnant woman and the fetus. The only effective and safe method of preventing chickenpox is protective vaccination.Aim. This study aims to assess the risk of contracting the Varicella-zoster infection in a selected population of hospital workers, as well as the further transmission of the virus to newborns, mothers and older children.Materials and Methods. A survey was conducted in September 2014 in three public hospitals in Poznań, among nurses and midwives working in paediatric, neonatal and maternity wards. 136 nurses and midwives participated in the survey.Results. The analysis of the findings reveals that 114 staff members of the hospital wards, i.e. 83.82%, have had chickenpox in the past, 14 respondents (10.29%) have never had this illness, and 8 (5.88%) do not know if they have been ill, which means that 16% of the respondents could potentially contract chickenpox. For the majority of nurses and midwives (103) the infection had taken place before they started work. However, 11 respondents (8,08) were infected during employment.Conclusions. 1) Nearly one out of 4 hospital staff members had no history of chickenpox contraction at the beginning of their employment. 2) Nearly 15% of the workers confirm that at the beginning of employment their immunity status was established on the basis of an interview. 3) The majority of employees negatively interviewed for chickenpox history have not been recommended to be vaccinated against this disease.
Assessment of women’s awareness about reproductive and breast cancers
Authors: Kosińska Karina Weronika , Lubawa Weronika Maria , Szczęśniak Magdalena , Plagens-Rotman Katarzyna , Miechowicz Izabella , Bączyk Grażyna , Ulatowska Agnieszka , Umbreit Michał 
Published: April 2017

Introduction. The aspect of prevention and treatment of malignant tumours is a key problem of public health in Poland, posing a great challenge for the health care system. A perfect method of fighting against neoplasms is prevention. Its widespread use may allow reduction in the risk of developing cervical and breast cancer. Aim. The aim of the paper was to assess women’s awareness about prophylaxis and risk factors related to the development of reproductive and breast cancers among women subject to the survey. Materials and Methods. The analysis comprised a group of 154 women at the age from 17 to 70. The study was conducted between 17 March and 30 July 2015. The research tool used in the study was an independently prepared survey questionnaire. Results. The biggest group of respondents (48.70%) was made up of women at the age from 20 to 30. 68.83% of the women had a secondary level education, 42.20% were women from cities of between 51.000 to 100.000 inhabitants and only 1.94% represented large cities of over 500.000 inhabitants. A change in the size or shape of the breast (88.96%) and changes in the look of the nipple (86.36%) were quoted as the most frequent symptom of breast cancer.Conclusions. The knowledge about reproductive organs and breast cancer prevention among women is not fully satisfactory and needs to be broadened. Media (internet, television) were the most popular source of information on cancer prevention among the respondents. It is necessary for family doctors and midwives to intensify health-care activities aimed especially at women who are the age associated with an increased risk for cancer.
Products of plant origin – benefits and the potential risk for the consumer
Authors: Karasiewicz Monika , Bogacz Anna , Krzysztoszek Jana , Pędziwiatr Daniel , Czerny Bogusław 
Published: April 2017

Phytochemical compounds are widely used in traditional medicine in the treatment of many ailments. In recent years, an increasing interest is observed in the use of new natural bioactive substances and whole standardized extracts in the prevention and therapy of diseases. Some of these are the components of the diet, diet supplements or at higher doses are used as herbal medicines. Many phytochemicals have documented a beneficial effect on health, but they must be used properly. Therefore, it is important to inform about differentiating between herbal medicine and dietary supplement. Further, the possibility of interactions with synthetic drugs and the mechanisms of these effects is necessary to describe for the safety of phytotherapy. The goal of our paper is to show high prophylactic and medicinal potential of natural active compounds of plant origin. We also want to draw attention to the safety of their use by the consumer. Therefore, we present some studies on the benefical properties of natural active compounds, mainly in the prevention and treatment of cancers and neurodegenerative diseases. The results of the described studies are extensively discussed and their suitability for further testing in vivo and in clinical trials is examined. At the same time we show selected interaction of common medicinal plants or their raw materials with synthetic drugs.
Endoleaks after endovascular abdominal aortic aneurysm repair
Authors: Kramek Jakub Tomasz , Stępak Hubert , Oszkinis Grzegorz 
Published: April 2017

Traditional surgical repair and endovascular repair (EVAR) are the treatment options for abdominal aortic aneurysm repair. EVAR as less invasive becomes a significant and widely accepted way of treatment aortic aneurysms with expanding number of procedures. This technique has a lover short-term mortality and a shorter hospital stay but is not free from complications. The most common complication after EVAR are endoleaks. For the first time summarised and assessed in 1997. Although it is often asymptomatic but may cause aneurysm expanding and rupture. Endoleak is defined as persistent blood flow into the aneurysm sac. It can be revealed intra-operatively or during the follow up – CT; arteriography, angio-MRI enables endoleak diagnosis. Usage of duplex sonography is questionable. In this mini-review we summarise endolek diagnostic, classification and treatment options.
Major adverse cardiovascular events in patients after acute myocardial infarction treated invasively and different patterns of glucometabolic disturbances evaluated at mid-term follow-up
Authors: Francuz Paweł , Podolecki Tomasz , Kozieł Monika , Kalarus Zbigniew , Kowalczyk Jacek 
Published: April 2017

Objective: To assess the impact of glucometabolic status (GS) evaluated at hospital discharge and at mid-term follow-up visit (FU-visit) on major adverse cardiovascular events (MACE) in patients (pts) with acute myocardial infarction (AMI) treated invasively.Material and Methods: Study encompassed 368 AMI-pts treated invasively, in whom GS was assessed by 2-hour post load glycemia at hospital discharge and at FU-visit after 6 months. Patients were divided into two groups with respect to GS at hospital discharge: abnormal glucose tolerance (AGT, n=149), normal glucose tolerance (NGT, n=219). Each of those groups was divided into two subgroups with respect to GS at FU-visit: persistent AGT (pAGT, n=101), transient AGT (tAGT, n=48), newly detected AGT (newAGT, n=114), persistent NGT (pNGT, n=105). Median follow-up duration after FU-visit was 24.5 months.Results: There was a trend towards more subjects with MACE in AGT than NGT group (24.2% vs. 16%; p=0.051). More AGT-pts were hospitalized due to decompensated heart failure (6% vs. 0.5%; p=0.002). However, there were no significant differences in MACE between subjects with pAGT and tAGT, including heart failure hospitalizations. Among NGT-pts there were no significant differences in particular MACE between newAGT-pts and pNGT-pts.Conclusions: In AMI-pts treated invasively, who had abnormal glucose tolerance at hospital discharge, the improvement in glucometabolic status after 6 months was not related to lower risk of hospitalization due to decompensated heart failure.
Cognitive functioning of women in pregnancy and early postpartum
Authors: Płotek Włodzimierz , Czarnecka-Iwańczuk Marta , Grześkowiak Małgorzata 
Published: April 2017

Pregnancy and early postpartum is an extremely stressful time in a woman’s life. Emotional and cognitive functioning are mutually interconnected. The psyche also influences the physical health on the functional and physical basis. The physiological hormonal changes adapt woman to the development and labour of a child and reflect in the central nervous system functioning. In the presented manuscript, the basic psychological problems accompanying women in this period, as well as mutual relationships between the hormonal and central nervous systems during pregnancy and early postpartum have been presented.
Factors associated with overhydration in peritoneal dialysis patients
Authors: Sikorska Dorota , Pawlaczyk Krzysztof , Olewicz-Gawlik Anna , Roszak Magdalena , Samborski Włodzimierz , Baum Ewa , Kałużna Małgorzata , Wanic-Kossowska Maria , Lindholm Bengt , Oko Andrzej 
Published: April 2017

Aim. Overhydration is a prevalent problem in peritoneal dialysis (PD) patients. The aim of the study was to evaluate the effect of several factors on the development of overhydration in PD patients. Material and Methods. The study was performed on 74 PD patients, who were divided into two groups according to bioimpedance analysis hydration status (OHBIA): Group A OHBIA < 1.1 L (n = 40) and Group B OHBIA ? 1.1 L (n = 34). The assessments of the adequacy of the dialysis dosage were based on the Kt/V ratio as well as weekly creatinine clearance. To evaluate the permeability of the peritoneal membrane a standard peritoneal equilibration test was used.Results. A statistically significant difference between the groups was found in: the average age of patients (53 ± 18 vs. 62 ± 14 years; p < 0.03), the prevalence of diabetes (27.5% vs. 55.9%; p < 0.02) and residual diuresis (1.7 ± 0.8 vs 1.2 ± 0.9 L; p < 0.05). There was no statistically significant difference in gender distribution, although attention is paid to the greater participation of male in overhydrated group. The study found no statistically significant differences between PD vintage, type of PD, assessment of adequacy of PD and other parameters describing the PD method. Logistic regression model selected diabetes (p < 0.03) as a significant risk factor for the occurrence of hypervolemia.Conclusions. Diabetes and older age are potential predisposing factors for the development of overhydration in PD patients. Overhydrated PD patients may have relatively high parameters regarding adequacy of dialysis therapy. Probably the most important protective factor in PD patients is residual diuresis
Surgery of early stage breast cancer in older women – multicenter study and review of 143 cases
Authors: Saad Abdalla Abdalla , Adamczyk Beata 
Published: April 2017

Most of breast cancers are diagnosed in females over 50 years of age, however it is found that about 30% of the disease diagnosed with women above 70 years. Generally speaking, those patients is treated with a smaller range of treatment which usually offered to the younger group of patients. Despite the presence of many comorbidities, however the patient may still have a good physiological reserve, which make offering a radical surgery of the cancer very possible. Age should not be a determinant for quality of care in breast cancer. In this paper, we looked to 143 breast cancer patients with age >70 years had been operated. The oldest was 86. ASA assessment tool used Pre-operatively. Mastectomy done in 70% where 30% underwent Breast Conservation Surgery. Axillary surgery done in 94% of cases (52% Sentinel lymph node biopsy and 42% axillary clearance). The histology of the removed cancers showed invasive ductal carcinoma in 76% of cases, invasive lobular carcinoma in 11%, with DCIS in 06%. After surgery, every patient has been offered the individual suitable adjuvant treatment as chemotherapy, radiotherapy, Herceptin or hormonal manipulation. As those patients can stand the radical surgery and live with a good life quality after treatment, we advise to extend the screening program beyond the current recommended age. Also we recommend further research to understand more about the biology of the breast cancer in the older age group and disseminate geriatric assessment tool as Adult Co-morbidity Evaluation (ACE-27) to provide a proper evaluation of the patient status prior to final management decision.