bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management and Outcome in Patients with Advanced Juvenile Nasopharyngeal Angiofibroma
Authors: Rupa Vedantam , Mani Sunithi , Backianathan Selvamani , Rajshekhar Vedantam 
Published: November 2017

Objective To report the management outcome in a series of patients with advanced juvenile nasopharyngeal angiofibroma (JNA).
Design Retrospective study.
Setting Tertiary care teaching hospital.
Participants Forty-five patients classified as Radkowski stage IIIA or IIIB who presented to us over the past 10 years.
Main Outcome Measures Surgical approaches used and disease free outcomes in patients with advanced JNA.
Results Surgical access for the extracranial component included open (41.9%) and expanded endonasal approaches (58.1%). Craniotomy (16.3%), endoscopy-assisted open approach (7%), or expanded endonasal approach (20.9%) was performed to excise the skull base or intracranial component. Follow up ranged from 4 to 96 months (mean, 20.3 months). Of 35 patients who underwent imaging at the first postoperative follow up, 25 (71.4%) had negative scans. Three symptomatic patients with residual disease underwent endoscopic excision and had negative scans thereafter. Of two others who had radiation therapy, one was disease free and the other lost to follow up. Five others had stable, residual disease. Three patients (8.6%) with recurrent disease underwent surgical excision, of whom two had minimal, stable residual disease. At the last follow-up, 27 (77.1%) patients had negative scans, and 7 (20%) had stable residual disease with one (2.9%) patient lost to follow-up.
Conclusions Advanced JNA may be successfully treated in most cases with expanded endonasal/endoscopy assisted ± craniotomy approach after appropriate preoperative evaluation. At follow-up, only symptomatic patients or those with enlarging residue require treatment; periodic imaging surveillance is adequate for those with stable disease.
Vastus Lateralis Muscle Free Flap for Skull Base Osteoradionecrosis in Nasopharyngeal Carcinoma
Authors: Vlantis Alexander , Wong Eddy , Chiu Tor , Chan Jason 
Published: November 2017

Objectives To describe the first experience with a free vastus lateralis muscle-only flap to be used to cover and protect the exposed skull base and carotid artery from radiotherapy-induced skull base osteoradionecrosis (ORN).
Design Retrospective review of a case series.
Setting Tertiary academic medical center.
Participants Post treatment nasopharyngeal carcinoma patients with skull base ORN.
Main Outcome Measures Coverage of the internal carotid artery (ICA).
Results Four patients underwent the procedure. Following the procedure, all patients were documented to have adequate viable soft tissue covering their ICA. Topical nasal steroids were prescribed to all patients as florid granulation tissue was noted to occur overlying the muscle flap in the early postoperative period. There were no flap failures. All patients noted an improvement in speech, cacosmia, and nasal crusting. No significant epistaxis occurred following surgery. Choanal stenosis was noted in three patients.
Conclusion For skull base ORN resulting from the treatment of nasopharyngeal carcinoma (NPC) with radiotherapy that fails conservative management, an open approach to the nasopharynx, that allows debridement then placement of a vastus lateralis muscle-only free flap for coverage, offers a unique and viable approach to the management of this challenging condition.
Is Ovarian Cancer Prevention Currently Still a recommendation of Our Grandparents?
Authors: Jammal Millena Prata , Lima Cid Almeida de , Murta Eddie Fernando Candido , Nomelini Rosekeila Simões 
Published: November 2017

AbstractOvarian cancer is the leading cause of death among gynecologic tumors because in most of the cases (75%), the disease is diagnosed in advanced stages. Screening methods are not available since the disease is rare, and the tested methods, such as ultrasound and CA125, were not able to decrease the mortality rate for this type of cancer. This article discusses the main risk factors for ovarian cancer, and the potential clinical and surgical strategies for the prevention of this disease.
Surgical Approach to Anorectal Melanoma with PET-CT Staging: A Case Report
Authors: Bulut Nilufer , Dagıstanlı Sevinc , Yılmaz Burcak , Atay O. 
Published: November 2017

AbstractRectal hemorrhage should be evaluated within a wide spectrum ranging from benign diseases to a malignant process. Especially, the melanomas of rectum are detected at an advanced stage when diagnosed since the present symptoms of rectal melanomas are similar. The question of what will be the surgical approach with MR, CT, and PET-CT imaging methods performed after histopathological diagnosis still conserves its topicality. PET-CT is a good imaging method for determination of distant metastasis and lymphatic involvement. In the present case, a patient with early-stage rectal melanoma was treated with APR. No relapse/metastasis was detected during the 18-month follow-up. The aggressive course of the disease and its low response rates to medical treatments may cause the surgical approaches to be more extensive.
Modic Type 1 Changes: Detection Performance of Fat-Suppressed Fluid-Sensitive MRI Sequences
Authors: Finkenstaedt Tim , Del Grande Filippo , Bolog Nicolae , Ulrich Nils , Tok Sina , Kolokythas Orpheus , Steurer Johann , Andreisek Gustav , Winklhofer Sebastian ,   on behalf of the LSOS Study Group
Published: November 2017

Purpose To assess the performance of fat-suppressed fluid-sensitive MRI sequences compared to T1-weighted (T1w) / T2w sequences for the detection of Modic 1 end-plate changes on lumbar spine MRI.
Materials and Methods Sagittal T1w, T2w, and fat-suppressed fluid-sensitive MRI images of 100 consecutive patients (consequently 500 vertebral segments; 52 female, mean age 74 ± 7.4 years; 48 male, mean age 71 ± 6.3 years) were retrospectively evaluated. We recorded the presence (yes/no) and extension (i. e., Likert-scale of height, volume, and end-plate extension) of Modic I changes in T1w/T2w sequences and compared the results to fat-suppressed fluid-sensitive sequences (McNemar/Wilcoxon-signed-rank test).
Results Fat-suppressed fluid-sensitive sequences revealed significantly more Modic I changes compared to T1w/T2w sequences (156 vs. 93 segments, respectively; p < 0.001). The extension of Modic I changes in fat-suppressed fluid-sensitive sequences was significantly larger compared to T1w/T2w sequences (height: 2.53 ± 0.82 vs. 2.27 ± 0.79, volume: 2.35 ± 0.76 vs. 2.1 ± 0.65, end-plate: 2.46 ± 0.76 vs. 2.19 ± 0.81), (p < 0.05). Modic I changes that were only visible in fat-suppressed fluid-sensitive sequences but not in T1w/T2w sequences were significantly smaller compared to Modic I changes that were also visible in T1w/T2w sequences (p < 0.05).
Conclusion In conclusion, fat-suppressed fluid-sensitive MRI sequences revealed significantly more Modic I end-plate changes and demonstrated a greater extent compared to standard T1w/T2w imaging.
Key Points
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Personal Preference of Mode of Delivery. What do Urogynaecologists choose? Preliminary Results of the DECISION Study
Authors: Bihler Julia , Tunn Ralf , Reisenauer Christl , Pauluschke-Fröhlich Jan , Wagner Philipp , Abele Harald , Rall Katharina , Naumann Gert , Wallwiener Markus , Brucker Sara , Hübner Markus 
Published: November 2017

Abstract
Introduction Currently, almost every third child in Germany is delivered by caesarean section. Apart from straightforward and clear indications for caesarean section which account for approx. 10%, the large proportion of relative indications in particular needs to be critically reviewed if the current C-section rate is to be effectively lowered. It is more than doubtful, however, whether this can be a realistic goal in Germany, especially in the context of international developments. All studies on this topic demonstrate that the personal attitude of the obstetric team has a considerable influence on the pregnant womanʼs personally preferred mode of delivery. Therefore, in the first part of the DECISION study, the personal preferences of urogynaecologists were evaluated regarding the best suitable mode of delivery.
Material and Methods All 432 delegates at the 9th German Urogynaecology Congress in Stuttgart in April 2017 were invited to participate in an online questionnaire study. The questionnaire was developed especially for this study.
Results Of the 432 registered delegates, 189 (43.8%) participated in the survey. 84.7% (n = 160) of the study participants would prefer a vaginal delivery, in an otherwise uncomplicated pregnancy. Only 12.2% (n = 23) opted for an elective caesarean section. The main reasons stated for this decision were concerns about incontinence (87.5%) and pelvic floor trauma (79.2%). Amongst the study participants, 83.6% would like to be part of a risk stratification system presented in the questionnaire which, with the aid of specific parameters, is intended to allow early identification of a population with a high risk of developing pelvic floor disorders. There was also great interest in postpartum pelvic floor recovery (97.8%) and an associated optional pessary therapy (64.4%). The type of delivery already experienced (vaginal delivery vs. primary caesarean section) and parity also reveals to have a significant influence on the personal preferred mode of delivery as well.
Conclusions Urogynaecologists prefer vaginal delivery for themselves. There is a great interest to participate in a risk stratification process in order to approach childbirth in an individualized and risk-adapted manner.
Vitreomakuläres Traktionssyndrom im Rahmen der Anti-VEGF-Therapie – 2 Kasuistiken
Authors: Wallraf Sophie Helene , Markova Kristina , Haritoglou Christos 
Published: November 2017

ZusammenfassungDas vitreomakuläre Traktionssyndrom (VMTS) wird definiert als partielle hintere Glaskörperabhebung mit persistierender vitreomakulärer Anhaftung. Bisher wurden traktive Veränderungen im Rahmen der Anwendung von VEGF-Hemmern im Wesentlichen im Sinne vitreoretinaler Traktionen im Rahmen der Therapie proliferativer ischämischer Netzhauterkrankungen wie der proliferativen diabetischen Retinopathie (PDR) beschrieben. In dieser Kasuistik werden 2 Fälle vorgestellt, bei denen Patienten mit einer altersbedingten neovaskulären Makuladegeneration und einem diabetischen Makulaödem als Folge einer Therapie mit VEGF-Hemmern ein ausgeprägtes VMTS entwickelten. Ein VMTS im Rahmen einer Anti-VEGF-Behandlung bei einer exsudativen Makulaerkrankung ist selten. Der genaue Pathomechanismus ist bisher unklar. Es wird diskutiert, dass die Anwendung von VEGF-Hemmern und die damit verbundene Fibrosierung bei noch anliegendem Glaskörper zu ausgeprägten Traktionen im vitreoretinalen Interface führen.
Progranulin and insulin-like Growth Factor Binding Protein-2 as Biomarkers of Disease Activity and Pathological Changes in Lupus Nephritis
Authors: Goma Samar , Abdelaziz Marwa , El-Hakeim Eman , El Zohri Mona , Sayed Sohair 
Published: November 2017

Abstract
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease, characterised by the production of auto-antibodies and the formation of immune complexes due to the polyclonal activation of T and B lymphocytes, which results in tissue and organ damage. During inflammation, neutrophils and macrophages release serine proteases to cleave progranulin (PGRN) into granulin, which exerts its pro-inflammatory effects that counteract the anti-inflammatory effects of intact PGRN. It is suggested that insulin-like growth factor binding protein-2 (IGFBP-2) is a dependable biomarker of renal deterioration but it is still unclear if it has high sensitivity and specificity for discriminating SLE-caused kidney disease from other-cause kidney disease.This study aimed to investigate the diagnostic value of PGRN and ILGFBP-2 in patients with lupus nephritis (LN) and the correlation of these biomarkers with disease activity and renal biopsy pathology.
Patients and methods Patients with SLE (n=25) and chronic kidney disease (CKD) (n=25), and age- and sex-matched controls (n=25) were enrolled in the study. Serum PGRN and ILGFBP-2 levels were measured for each group.
Results Disease duration was 4.78±4.26 years in the SLE patients. The mean SLE Disease Activity Index score was 15.04±7.54. All renal biopsy results were class 2, 3, and 5 with a percentage of 32, 24, and 44% respectively. PGRN and ILGFBP-2 were significantly higher in SLE patients (p<0.001 all) than in the CKD and control groups. All patients with high levels of biomarkers showed higher values of SLE disease activity. No significant difference was noted between active and inactive LN or classes of renal biopsy with PGRN and ILGFBP-2.
Conclusion PGRN and ILGFBP-2 are significantly elevated in SLE compared to CKD and the general population and were associated with the SLE Disease Activity Index but not with active LN or classes of renal biopsy.
Solving visual correspondence between the two eyes via domain-based population encoding in nonhuman primates
Authors: Chen Gang , Lu Haidong D. , Tanigawa Hisashi , Roe Anna W. 
Published: November 2017

Significance
A long-standing problem in visual depth perception is how corresponding features between the two eyes are matched (the “binocular correspondence problem”). Here, we show, using optical imaging in monkey visual cortex, that this computation occurs in the near and far disparity domains of V2, and that functional organization in V2 might facilitate the pooling of disparity signals that can reduce false matches to solve the binocular correspondence problem.
SUMOylation and ubiquitination reciprocally regulate α-synuclein degradation and pathological aggregation
Authors: Rott Ruth , Szargel Raymonde , Shani Vered , Hamza Haya , Savyon Mor , Abd Elghani Fatimah , Bandopadhyay Rina , Engelender Simone 
Published: November 2017

Significance
Our work uncovers SUMOylation as a major regulator of α-synuclein fate and pathological aggregation. SUMOylation promotes α-synuclein accumulation by counteracting α-synuclein ubiquitination and inhibiting its degradation. SUMOylation also directly causes aggregation of α-synuclein in vitro and in cells, and the effects are much more prominent with the α-synuclein disease mutants. Most importantly, levels of SUMOylated α-synuclein and components of the SUMOylation machinery increase severalfold in Parkinson’s disease (PD) brains and are present in Lewy bodies. Our data indicate a major role of SUMOylation in the pathological aggregation of α-synuclein and Lewy body formation. Therefore, SUMOylation blockers provide a strategy to prevent intracellular α-synuclein accumulation, aggregation, and spreading in PD.
Def1 interacts with TFIIH and modulates RNA polymerase II transcription
Authors: Damodaren Nivedita , Van Eeuwen Trevor , Zamel Joanna , Lin-Shiao Enrique , Kalisman Nir , Murakami Kenji 
Published: November 2017

Significance
All eukaryotes respond to DNA damage by polyubiquitylation and degradation of the largest subunit of RNA polymerase II (pol II), facilitated by the Elongin-Cullin ubiquitin ligase. In yeast, the recruitment of the ubiquitin ligase to pol II is dependent on Def1. We report a finding made in the course of isolating TFIIH-Def1 from yeast that suggests a potential novel function of Def1 as a transcription regulator in response to cellular stress. The function of Def1 in transcription regulation is demonstrably separable from its role in coordinating pol II stability in response to cellular stress.
Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival
Authors: Gao Hong , Zhao Lu , Wang Hao , Xie Enjun , Wang Xinhui , Wu Qian , Yu Yingying , He Xuyan , Ji Hongbin , Rink Lothar , Min Junxia , Wang Fudi 
Published: November 2017

Significance
Zn is essential for maintaining the integrity of the immune system, and Zn homeostasis is tightly regulated by two families of ion transporters, SLC39A and SLC30A. Worldwide, an estimated two billion people have Zn deficiency, a condition that can impair immune function and increase susceptibility to a variety of infections. Despite their important roles in health and disease, the molecular mechanisms that underlie Zn transport and Zn homeostasis in macrophages are poorly understood. Here, we report that SLC39A10 plays an essential role in Zn homeostasis in macrophages, regulating the immune response following inflammatory stimuli. Specifically, we identified a role for SLC39A10 in regulating the survival of macrophages via a Zn/p53-dependent axis during the inflammatory response.
Proton movement and coupling in the POT family of peptide transporters
Authors: Parker Joanne L. , Li Chenghan , Brinth Allete , Wang Zhi , Vogeley Lutz , Solcan Nicolae , Ledderboge-Vucinic Gregory , Swanson Jessica M. J. , Caffrey Martin , Voth Gregory A. , Newstead Simon 
Published: November 2017

Significance
The uptake of nutrients from the environment is an essential process that is achieved in most cells through the use of secondary active transporters. The POT family of proton-coupled peptide transporters are one of the most diverse nutrient uptake systems, recognizing amino acids, peptides, nitrate, and seed-defense compounds. A long-standing question is how this family achieves such ligand diversity. A high-resolution crystal structure combined with multiscale molecular dynamics simulations demonstrate water molecules are able to shuttle protons using a Grotthuss-type mechanism, suggesting a separation of ligand recognition from proton movement. This would have clear advantages for a transporter family that must accommodate chemically diverse ligands while retaining the ability to couple transport to the proton electrochemical gradient.
Development of self-protective biases in response to social evaluative feedback
Authors: Rodman Alexandra M. , Powers Katherine E. , Somerville Leah H. 
Published: November 2017

Significance
The growing popularity of social media, especially among youth, has resulted in peer feedback (including rejection) pervading everyday life. Given that peer ostracism has been linked to depression and suicide, it is critical to understand the psychological impact of peer feedback from a developmental perspective. We demonstrate that adolescents and adults use peer feedback to inform views of themselves and of others in very different ways. Of particular interest, early adolescents internalized rejection from peers and felt worse about themselves, whereas adults exhibited evidence of self-protective biases that preserved positive self-views. This work advances theoretical insights into how development shapes social-evaluative experiences and informs sources of vulnerability that could put adolescents at unique risk for negative mental health outcomes.
Fishnet model for failure probability tail of nacre-like imbricated lamellar materials
Authors: Luo Wen , Bažant Zdeněk P. 
Published: November 2017

Significance
The astonishing strength enhancement in the nacre of pearl oyster, compared with its main constituent, the aragonite, has recently been explained by the nanostructure of overlapping nanoscale platelets—but only deterministically. It is also necessary to know the stress value for which the failure probability does not exceed 1 in a million. It is shown that, at such a low-failure probability, the nacre-like structures exhibit additional advantages. The strength increases by about 10%, while at fixed, correspondingly low, stress, the failure probability decreases by 1 to 2 orders of magnitude, compared with the standard (Weibullian) extrapolation from the deterministic prediction and coefficient of variation. These are advantages important for biomimetic engineering applications.
The compliment response strategies of Egyptian Arabic-English bilinguals
Authors: Salam El-Dakhs Dina Abdel 
Published: November 2017

Abstract
The present study examined the compliment response behaviour of Egyptian Arabic-English bilinguals in both spoken Egyptian Arabic and English. A total of 433 undergraduates completed the Arabic and English versions of a Discourse Completion Task comprising 12 imaginary situations that varied in topic and in the relation between the interlocutors. The results revealed the participants’ preference for agreement and additional response types in both Arabic and English to varying extents while non-agreement responses were rarely used. Significant differences were noted for language type, gender, social distance, social dominance and topic while exposure to the foreign language resulted in minimal differences. Results are interpreted within a pragmatic and sociolinguistic framework and implications are proposed.
The language of Akan herbal drug sellers and advertisers
Authors: Agyekum Kofi 
Published: November 2017

Abstract
This paper addresses the language and pragmatic strategies used by Akan herbal drug sellers to persuade would-be-buyers. It adopts the theoretical framework of Weigand’s Mixed Game Model (MGM) and defines persuasion as a variable of competence-in-performance, and language use as the basis of dialogic interaction. It investigates how sellers employ politeness, honorifics, humour, digression, personification, proverbs, metaphors and hyperbole in dialogic action games. The herbal drug sellers are grouped into three: (a) those normally plying on Ghana’s major roads and at bus stations, (b) those who are on radio and TV and (c) those who advertise on radio and TV. We will discuss excerpts of five recordings in the Akan language and translated into English.
Biodegradation of high concentrations of formaldehyde using Escherichia coli expressing the formaldehyde dismutase gene of Methylobacterium sp. FD1
Authors: Yonemitsu Hiroshi , Kikuchi Yuta 
Published: November 2017

Abstract
In the present study, formaldehyde dismutase from Methylobacterium sp. FD1 was partially purified and analyzed by nanoLC–MS/MS; it was then cloned from the genomic DNA of FD1 by PCR. The open reading frame of the formaldehyde dismutase gene of FD1 was estimated to be 1203 bp in length. The molecular weight and pI of formaldehyde dismutase (401 aa), as deduced from the FD1 gene, were calculated at 42,877.32 and 6.56, respectively. NAD(H)-binding residues and zinc-binding residues were found in the amino acid sequence of the deduced formaldehyde dismutase of FD1 by BLAST search. The resting Escherichia coli cells that were transformed with the FD1 formaldehyde dismutase gene degraded high concentrations of formaldehyde and produced formic acid and methanol that were molar equivalents of one-half of the degraded formaldehyde. The lyophilized cells of the recombinant E. coli also degraded high concentrations of formaldehyde.