bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrolental cohesive ophthalmic viscoelastic injection for severe subluxated cataracts: a prospective study
Authors: Iannetta Danilo , Romano Vito , Valsecchi Nicola , Grendele Arianna , Febbraro Simone , Marenco Marco , Moramarco Antonio , Lambiase Alessandro , Fontana Luigi 
Published: September 2024

Abstract
Background
To assess anatomical and functional outcomes of retrolental cohesive ophthalmic viscoelastic injection (“Viscolift technique”) in patients with severely subluxated cataracts.

Methods
In the present prospective study, we included patients older than 18 years with severely subluxated cataracts and phacodonesis. Full medical history was obtained at the baseline ophthalmological assessment. A single 25-gauge valved trocar was inserted 4 mm from the limbus and a 27G angled cannula was introduced through the trocar into the retrolental space, while cohesive viscoelastic was progressively injected, in order to center and elevate the cataract to facilitate capsulorhexis. After complete phacoemulsification, a 3-piece intraocular lens (IOL) with a scleral fixated Cionni ring or FIL-SSF scleral fixated IOL was implanted. Patients follow-up interval was 6 months after surgery.

Results
Thirteen eyes of 13 patients were enrolled in the study, mean age was 61.5 ± 9.4 years and 53.8% were females. The “Viscolift technique” resulted in centered and more stable cataracts in all cases (100%). After complete phacoemulsification, 61.5% of patients were implanted with a 3-piece IOL with Cionni ring, and 38.5% with a FIL-SSF scleral fixated IOL after complete 25G vitrectomy. Mean BCVA improved from 0.5 ± 0.1 LogMar (20/63 Snellen) to 0.1 ± 0.1 LogMar (20/25 Snellen) (p < 0.001) at the last follow-up. No major complications were noted.

Conclusions
The “Viscolift technique” proved to be a safe and effective surgical approach for recentering and elevating subluxated cataracts, thus allowing the surgeon to perform an easier and better-centered capsulorhexis.
Search efforts and face recognition: the role of expectations of encounter and within-person variability in prospective person memory
Authors: Moore Kara N. , Nesmith Blake L. , Zwemer Dara U. , Yu Chenxin 
Published: September 2024

AbstractPeople perform poorly at sighting missing and wanted persons in simulated searches due to attention and face recognition failures. We manipulated participants’ expectations of encountering a target person and the within-person variability of the targets’ photographs studied in a laboratory-based and a field-based prospective person memory task. We hypothesized that within-person variability and expectations of encounter would impact prospective person memory performance, and that expectations would interact with within-person variability to mitigate the effect of variability. Surprisingly, low within-person variability resulted in better performance on the search task than high within-person variability in Experiment one possibly due to the study–test images being rated as more similar in the low variability condition. We found the expected effect of high variability producing more hits for the target whose study–test images were equally similar across variability conditions. There was no effect of variability in Experiment two. Expectations affected performance only in the field-based study (Experiment two), possibly because performance is typically poor in field-based studies. Our research demonstrates some nuance to the effect of within-person variability on search performance and extends existing research demonstrating expectations affect search performance.
Mediation/moderation effects of engagement, foreign language enjoyment, and ambiguity tolerance in metaverse-based foreign language learning
Authors: Zhang Qi 
Published: September 2024

AbstractThis study investigates how engagement (E), foreign language enjoyment (FLE), and ambiguity tolerance (AT) exert mediation/moderation in metaverse-based foreign language learning (FLL). Featuring augment/simulation-based experiences and self-fulfillment/external-control-oriented mechanics, metaverse provides virtualized interactive circumstances involving individuals’ embodied presence/behaviors, aligning with FLL that emphasizes social interaction. Based on the quantified survey data, partial least squares structural equation modeling (PLS-SEM) analyses investigate the significance and positivity of the mediation/moderation relations. According to the results, E exerts fully positive mediation in the effect of intrinsic motivation (IM) on learning effectiveness (LE), FLE exerts partially positive mediation in the effect of classroom social climate (CSC) on E, and AT exerts negative moderation in the positive effect of E on LE. Notably, FLE exerts insignificant mediation in the effect of growth mindset (GM) on E. Therefore, efficient metaverse-based FLL requires synergies of affective factors, i.e., intrinsic motivation, perceptions of classroom social climate, moderate degrees of ambiguity tolerance, and engagement, for sustainable and long-term language learning progress in virtual interactive experiences. At the theoretical level, the findings extend the FLL-related models and advance the understanding of FLL. At the practical level, the findings provide references for more efficient metaverse implementations in FLL.
Demand-driven capacity building for public health nutrition research in Lao PDR
Authors: Shively Gerald , Ambikapathi Ramya , Eddens Kate , Ghosh Susmita , Gunaratna Nilupa S. , Khamphouxay Kelley , Oula Ratthiphone , Ratsavong Kethmany , Saylath Thipphakesone , Siengsounthone Latsamy , Sipes Patricia , Sychareun Vanphanom , Tekwe Carmen , Thompson Leah , Thongmixay Souksamone , Vongxay Maikho , Vongxay Viengnakhone , Zoh Roger 
Published: September 2024

AbstractIn Laos, rates of undernutrition, especially among children under 5 years of age, remain high. In response, a large multidisciplinary team embarked on a multi-year project in Laos beginning in 2019 with the purpose of institutional strengthening around public health nutrition research. This paper summarizes the Applied Nutrition Research Capacity Building project’s activities, immediate project results, and prospects for sustaining impacts into the future. Eight primary activities were undertaken, including back-office strengthening, mentored research, and curriculum review and development. Requested training and skill development in areas related to public health nutrition, anthropometry, and research methods reached more than 1000 professionals. The first edition of a Lao-English Nutrition Glossary was produced, as was the country’s first National Nutrition Research Agenda, a document which sets locally-identified priorities for future research. Project success was achieved by focusing on the priorities of project partners and the Lao government, as articulated in the Lao National Nutrition Strategy and Action Plan. Project design elements that could guide similar efforts undertaken elsewhere include multi-year engagement, an emphasis on sustained peer mentorship, and the use of an extended period of pre-planning in collaboration with project stakeholders prior to the start of activities.
Accelerating HPV vaccination in Africa for health equity
Authors: Asempah Eric , Ikpebe Ene 
Published: September 2024

AbstractCervical cancer is a preventable disease that continues to burden socioeconomically underserved regions, especially in Africa. Vaccination of adolescents who have never had sex with prophylactic human papillomavirus (HPV) vaccines proves effective in preventing the disease. However, vaccine accessibility and availability are two persistent challenges in low-resource settings. For this commentary, a trend analysis is conducted for national HPV vaccination and coverage rates in Africa, a region with high burden of the disease. This is in consideration of the World Health Organization (WHO) strategy to vaccinate 90% of adolescent girls by the age of 15, as part of strategy to eliminate cervical cancer by 2030. The analysis estimated that the rate of incorporating HPV vaccination in national immunization programs in Africa occurs slowly, at a mean wait time of 12 years with estimated coverage rate of 52%. A policy change that harnesses strategic approaches, such as a regionalized vaccination program, is recommended to hasten HPV vaccination for the rest of African countries without a national program.
Health-related quality of life among women diagnosed with in situ or invasive breast cancer and age-matched controls: a population-based study
Authors: Bøhn Synne K. H. , Svendsen Karianne , Balto A. , Gjelsvik Ylva Maria , Myklebust Tor Åge , Børøsund Elin , Eriksen Hege R. , Meland A. , Østby K. , Nes L. Solberg , Kiserud Cecilie E. , Reinertsen Kristin V. , Ursin G. 
Published: September 2024

Abstract
Purpose
A breast cancer (BC) diagnosis may negatively affect health-related quality of life (HRQoL). However, there are few comparisons of HRQoL at several time points for women with BC, and particular when subdivided into invasive and in situ tumors. The purpose of this study was to investigate various aspects of HRQoL in women recently diagnosed with invasive BC or ductal carcinoma in situ (in situ) compared to age-matched BC free controls in a population-wide sample recruited through the Cancer Registry of Norway.

Methods
This cross-sectional study utilized HRQoL data collected in 2020–2022 from a digital survey including 4117 cases (3867 women with invasive BC and 430 with in situ) and 2911 controls. HRQoL was assessed ≥ 21 days after diagnosis, using EORTC QLQ-C30. This includes scores assessing global quality of life (gHRQoL) and HRQoL functions and symptoms. Multivariable regression analyses were used to compare HRQoL between cases and controls and to identify factors associated with gHRQoL and fatigue. Additionally, HRQoL 14 months after diagnosis was analyzed in 1989 of the included cases and in 1212 of the controls. Score differences of ≥ 10 points were considered clinically relevant and thus presented in the results.

Results
Invasive BC cases had lower gHRQoL, role- and social functioning in addition to more fatigue than controls. In situ cases had lower role—and social functioning than controls. Invasive BC cases scored worse than in situ on all domains, but the differences were not considered clinically relevant. Physical activity was associated with better gHRQoL and less fatigue in invasive BC, in situ and controls. Both invasive BC and in situ cases improved their role- and social functioning scores from diagnosis to 14 months follow-up, however no improvement was seen for fatigue.

Conclusion
Women with invasive BC and in situ reported lower role- and social functioning scores than controls right after diagnosis with improvements 14 months after diagnosis. Physical activity was associated with better gHRQoL and less fatigue and should, whenever possible, play a key role in the care for BC patients.
Comparison of pulmonary vein isolation between two commercially available cryoballoon systems
Authors: Filipovic Karlo , Sultan Arian , Lüker Jakob , van den Bruck Jan-Hendrik , Wörmann Jonas , Scheurlen Cornelia , Schipper Jan-Hendrik , Dittrich Sebastian , Steven Daniel 
Published: September 2024

Abstract
Background
Pulmonary vein isolation (PVI) using cryoballoon (CB) ablation has comparable efficacy and safety to the gold standard of radiofrequency ablation in the treatment of symptomatic atrial fibrillation (AF). Initial randomized control trials were performed using Arctic Front Advance Pro™ (AFr) (Medtronic, Dublin, Ireland) CB system. Novel CB systems have recently become available, including the POLARx™ (Px) (Boston Scientific, Marlborough, Massachusetts, USA) system. We aimed to compare PVI using the Px and the AFr CB systems in our patient population in terms of efficacy, safety and procedure characteristics in a routine clinical setting.

Methods
We performed a retrospective analysis of our internal AF ablation registry, containing 452 consecutive patients (pts) that underwent first procedure cryo-PVI for symptomatic AF. Primary endpoints were AF recurrence after 3 and 12 months, complication rate, procedure duration, fluoroscopy time and fluoroscopy dose. Secondary endpoints were minimal freeze temperature, time to isolation (TTI) and temperature at TTI for each of the pulmonary veins as well as minimal esophageal temperature during the procedure.

Results
The primary efficacy endpoints of AF recurrence after 3 and 12 months were similar between the AFr and the Px systems (25.5% vs 21.3%, p = 0.416 and 22.2% vs 20.6%, p = 0.794, respectively). Complication rates were similar (3.9% vs 6.8%, p = 0.18) between groups and consisted mostly of mild vascular complications. The AFr group showed a significantly shorter procedural duration (68 (55–77) vs 73 (60–80) min, p = 0.002), and lower fluoroscopy dose compared to the Px system. Fluoroscopy times remained similar, however. Minimal freeze temperatures and temperatures at time of isolation were significantly lower in the Px group. However, the time to isolation and minimal procedural esophageal temperature were similar in both groups.

Conclusion
PVI using the AFr and the Px systems showed comparable safety and efficacy. Procedural times were longer for the Px system. The Px system showed lower freeze temperature measurements but seemed to have a comparable biological effect.
Mechanism of renal cyst formation in a child with tuberous sclerosis complex: a case report
Authors: Koç Ece , Leventoğlu Emre , Kavgacı Akif , Karaduman Alev Elçi , Hirfanoğlu Tuğba , Fidan Kibriya 
Published: September 2024

Abstract
Background
Tuberous sclerosis complex (TSC) is a multisystem genetic disorder characterized by the development of benign tumors in various organs, including the brain, kidneys, heart, lungs, skin, and eyes. Herein, an infant who was followed up with a diagnosis of TSC and multiple cysts which were found in the kidneys was presented, and the mechanism of renal cyst formation in TSC was elucidated.

Case presentation
An infant was referred to our hospital after delivery due to multiple cardiac homogeneous echogenicity in the antenatal period. Transthoracic echocardiography showed multiple rhabdomyomas in both ventricles. Three months later, she started to have seizures 1–3 times a day. Electroencephalography was compatible with active multifocal epileptic disorder and hypsarrhythmia. Brain magnetic resonance imaging revealed a thin corpus callosum, cortical and subcortical tubercles, and multiple subependymal nodules. Abdominal ultrasound revealed a multiloculated cyst reaching 1 cm in size in the liver, and multiple cortical cysts smaller than 6 mm were observed in both kidneys, in accordance with autosomal dominant polycystic kidney disease (ADPKD). Pathogenic deletions between 31–42 exons in TSC2 gene and 28–46 exons in PKD1 gene were detected, and the patient was diagnosed as PKD1/TSC2 contiguous gene deletion syndrome.

Conclusion
The coexistence of TSC and ADPKD is a rare occurrence but has been documented. Regular follow-up visits with healthcare providers, including nephrologists, cardiologist, neurologists, dermatologists, and other specialists as needed, are essential for the comprehensive management of coexistence of TSC and ADPKD. Individualized treatment plans should be developed based on the specific needs and manifestations of each patient, with a focus on optimizing outcomes and improving quality of life.
Analysis of third and fourth corneal high-order aberrations before and after small incision lenticule extraction (SMILE) in myopic and myopic astigmatic eyes using ray tracing aberrometry
Authors: Belgacem Sarra , Habani Saoussene , Guernazi Daoud , Kail Fatiha , Chiali Selma 
Published: September 2024

Abstract
Background
Aim is to analyze alterations in third and fourth corneal higher-order aberrations using a ray tracing aberrometer (iTrace) induced by SMILE (small incision lenticule extraction) refractive surgery on Algerian patients; and also to investigate how corneal aberrations vary with spherical equivalent (SE), corneal central thickness (CCT), and age. Design Prospective, non-randomized case series that were carried out at the Chiali Smile Center, Algiers, Algeria.

Participants
A total of 219 eyes from 110 myopic patients, with and without astigmatism, successfully concluded the ultimate follow-up. Participants exhibited an average age of 32.48 years, with preoperative mean corneal high-order aberrations (CHOA) measuring 0.005 ± 0.036 μm.

Methods
A tracking trend analysis of high-order aberrations (HOAs) was conducted on the three groups of patients, assessing total corneal high-order aberrations after SMILE over periods of two, six, and twelve months.

Results
A substantial increase in total corneal high-order aberrations following SMILE, with a P value < 0.05. Conversely, there was a noteworthy and significant decrease in vertical trefoil for all groups (P value = 0.000). Interestingly, the corneal higher-order aberrations were more pronounced after two months compared to the six and twelve-month intervals. Spherical aberration demonstrated a significant increase with the extent of preoperative myopia and preoperative spherical equivalent both before and after SMILE surgery (P < 0.05), particularly in cases of high myopia. Moreover, there were significant reductions in preoperative and postoperative vertical coma (P = 0.047, P = 0.004, respectively) corresponding to the degree of preoperative myopia, with a more substantial decrease in vertical coma observed in cases of low myopia.

Conclusion
In the post-SMILE period, a notable increase in vertical coma and spherical aberrations was observed, accompanied by a significant decrease in vertical trefoil across all eyes. These aberration changes were identified to be closely associated with the spherical equivalent.
Exploring of biological activity and diverse metabolites in hemp (Cannabis sativa) seed oil by GC/MS, GC–FID, and LC–HRMS chromatographies
Authors: Gulcin İlhami , Ozden Eda Mehtap , Mutlu Muzaffer , Mirzaee Ziba , Bingol Zeynebe , Köksal Ekrem , Alwasel Saleh , Goren Ahmet C. 
Published: September 2024

Abstract
Background
This study investigated the antidiabetic and antioxidant properties of hemp seed oil using various bioanalytical methods. Furthermore, this study determined the suppressive properties of hemp seed oil on α-amylase, acetylcholinesterase and carbonic anhydrase II that purified by the sepharose-4B-L-Tyrosine-sulfanilamide affinity chromatoghraphy, all of which are related to different metabolic diseases. Moreover, the phenolic concentration in the essential oil was quantified through LC–HRMS chromatography. Thirteen distinct phenolic compounds were detected in hemp seed oil. Additionally, both the chemical components and quantity of essential oils within hemp seed oil were assessed through GC–FID and GC/MS analyses.

Results
The predominant essential oils in hemp seed oil included linoleoyl chloride (34.62%), linoleic acid (33.21%), and 2-4-di-tert-butylphenol (5.79%). Hemp seed oil's ability to scavenge radicals was studied through the use of 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) and 1,1-diphenyl-2-picrylhydrazil bioanalytical radical scavenging methods. The results unveiled its potent radical-scavenging properties, with an 46.20 μg/mL for 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radicals and IC50 of 9.76 μg/mL for 1,1-diphenyl-2-picrylhydrazil radicals. The investigation also extended to explore the reducing capabilities of Fe3+-2,4,6-tri(2-pyridyl)-S-triazine, copper (Cu2+), and iron (Fe3+). Hemp seed oil demonstrated notable inhibitory effect against α-amylase (IC50: 545.66 μg/mL), achethylcholinesterase (IC50: 28.00 μg/mL), and carbonic anhydrase II (IC50: 322.62 μg/mL).

Conclusions
This interdisciplinary research will prove valuable and set the stage for future investigations into the antioxidant characteristics and enzyme inhibition patterns of plants and plants oils that hold medical and industrial significance.
Associations between early experiences of thought interference and auditory-verbal hallucinations with first-rank symptoms and suicidality in adulthood
Authors: Gofton Hannah , Rodriguez Henrietta , Sheridan-Guest Trinity , Baker Daniel H. , Humpston Clara S. 
Published: September 2024

Background
Suicide is one of the major causes of premature death in patients diagnosed with a schizophrenia-spectrum psychotic disorder. However, associations between psychotic-like experiences in youth and suicidality in later life remain under-researched.

Aims
We aimed to investigate any associations between early experiences of thought interference and auditory-verbal hallucinations (AVHs) with first-rank symptoms of schizophrenia and suicidal thoughts and behaviours in adulthood.

Method
This study used data from the Avon Longitudinal Study of Parents and Children (ALSPAC). We calculated combined thought interference score at ages 11 years 8 months, 13 years 1 month, 14 years 1 month and 16 years 6 months. We also assessed AVHs at the same age points. For outcome variables, we used specific variables measuring delusions of control, AVHs and suicidality at 24 years of age. We carried out logistic regressions and mediation analyses to assess the relationships among these variables.

Results
Thought interference and AVHs at all ages throughout childhood and adolescence were associated with suicidal thoughts and behaviours, and also with clinically more significant symptoms of delusions of control and AVHs at age 24. Substance use-induced psychotic-like experiences mediated a large proportion of the relationship between early psychotic-like experiences and suicidality in later life.

Conclusions
Thought interference and AVHs in childhood and adolescence are associated with first-rank symptoms and suicidality in adulthood. Mental health interventions in children and adolescents need to take into account the impact of specific psychotic-like experiences and allow for the early detection of thought interference and AVH-related symptoms.