bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clitic climbing in the speech of Braga and Lisbon
Authors: Barbosa Pilar , de Paiva Maria da Conceição , Martins Kellen Cozine 
Published: April 2017

Abstract
In European Portuguese, clitic pronouns can be attached to the highest verb in certain verbal clusters, a process known as clitic climbing (CC). According to some authors (Magro, 2005), CC is more productive in the Northern varieties of European Portuguese. In this chapter, we present and discuss the findings of a comparative analysis of Braga and Lisbon oral speech. Our main claim is that CC is a stable variation phenomenon. By means of a multivariate analysis, we show that CC is more frequent than attachment of the clitic to the infinitive in the two varieties. Moreover, we discuss evidence in favor of the claim that this syntactic variation presents the same configuration in both varieties: it is lexically constrained and not socially marked.
Growth and maturation
Authors: Baxter-Jones Adam DG 
Published: April 2017

Abstract
As children grow they increase in size and maturity. While growth refers to changes in size and complexity of tissue composition, maturation is the progressive achievement of adult status. A child’s growth status is an important determinant of current and lifelong health. Regular physical activity is required to obtain optimal growth. Normal healthy children show the same patterns of growth in terms of attainment of size and changes in proportionality. However, growth is not a linear process; the speed of statural growth decreases during infancy, is relatively constant during childhood, and accelerates during adolescence before slowing down in emerging adulthood. Although the patterns of growth are similar in all individuals, the timing and tempo of growth shows vast variability both within and between sexes. Thus it is important to remember that the effects of growth and maturation may mask or be greater than the effects of exercise.
Motor development
Authors: Sugden David , Soucie Helen 
Published: April 2017

Abstract
The development of motor skills in the first two years of life are dramatic, and then become more subtle with time. Chapter 4 describes these changes, and explains how these changes take place. Analysis is done via neuro-maturational theories, information processing, and cognitive terms as well as more recent ecological and dynamical systems viewpoints. The bidirectional influence of other faculties like embodied cognition and movement show that motor development does not occur in isolation. Movement skills are essential to daily life and influence our social, emotional, and cognitive being. This process of evolution and refinement is a complex, dynamic, self-organizing system. Theoretical explanations of motor development involve the transaction of children’s resources, the environmental context, and the task at hand. Not all children develop typically, although the influencing parameters are the same for all; rather, it is the metrics within the parameters that differ.
Muscle strength
Authors: De Ste Croix Mark BA 
Published: April 2017

Abstract
Strength increases in boys and girls until about the age of 14 years where it begins to plateau in girls and a spurt is evident in boys. By 18 years there are few overlaps in strength between boys and girls. The exact age in which gender differences become apparent is both muscle group- and muscle action-specific. There are few well controlled longitudinal studies that have concurrently examined the influence of known variables using appropriate statistical techniques. Most studies have shown that maturation does not exert an independent effect when other factors, such as stature and body mass, are accounted for. Additionally, the assumption that muscle cross-sectional area is the most important parameter in strength production does not hold when examined with other known variables. Consistently, stature appears to play a key role in strength development and this may be attributed to changes in the muscle moment arm.
Physical activity and bone health
Authors: Kemper Han CG , Fernandes Rômulo A 
Published: April 2017

Abstract
The growth and development of the skeleton during childhood and adolescence is an important determinant of the development of osteoporosis in later life. Therefore healthy behaviours adopted in early life are crucial in the promotion of bone health in adulthood. In the last decades, the available technology to monitor bone growth parameters has become more accurate and cheaper, improving the quality of longitudinal studies undertaken over the last few years. In childhood, the engagement in daily physical activities has a relevant impact on bone formation, mainly if weight-bearing activities are incorporated into it. The physical exercise-related osteogenic effects improve the bone health of boys and girls in different maturational stages. Moreover, the practice of organized sport incorporates osteogenic aspects, while well-structured physical education classes also seem relevant to improving bone health.
The assessment of physical activity
Authors: Hildebrand Maria , Ekelund Ulf 
Published: April 2017

Abstract
Physical activity (PA) is a complex human behaviour that comprises several dimensions, including intensity, frequency, duration, type/mode, and domain. PA outcomes can be divided into two main categories: the estimation of energy expenditure, and other quantifying metrics of PA. Subjective methods, including questionnaires and diaries, are often easy to use, cost-effective and are able to assess type of PA and to rank PA levels. However, they are prone to several limitations and are not able to provide accurate estimates of PA, energy expenditure, or intensity. Objective methods, including accelerometers and heart rate monitors, provide a reasonably accurate quantification of intensity, frequency, duration, and PA energy expenditure. When choosing a method for assessing PA several factors need to be considered, including validity, reliability, accuracy, and responsiveness, as well as the purpose of the study, the population being studied, and the outcome of interest.
Exercise, physical activity, and cerebral palsy
Authors: Dallmeijer Annet J , Balemans Astrid CJ , Verschuren Olaf 
Published: April 2017

Abstract
Children with cerebral palsy have major motor impairments that lead to reduced fitness and physical activity levels. Increased energy cost of walking in combination with reduced aerobic fitness induces high levels of physical strain that can lead to fatigue complaints and limited physical activity. To assess fitness, adapted laboratory and field exercise tests with good reliability and validity are available for both ambulant and wheelchair-using children with cerebral palsy. Children with cerebral palsy show increased sedentary time and low physical activity levels which relate to increased risks for health issues and loss of functional abilities at older age. Reducing sedentary time and increasing physical activity are important to counteract the increased health risks and loss of functional abilities. Fitness training of sufficient frequency, intensity, and duration is required to maintain and optimize long-term health and functional ability in children with cerebral palsy.
Protecting child athletes
Authors: Mountjoy Margo , Kirby Sandi , Tiivas Anne 
Published: April 2017

Abstract
Members of the athlete medical/sport science support team must be confident that athletes are benefitting from treatment, and that they are not victims of medical mismanagement. Athletes must not be treated differently to any other patient in society. This chapter discusses why protection of the child athlete is necessary, and how child athletes can be subjected to psychological abuse, which may form the gateway to other types of abuse. These can include physical abuse, sexual abuse, and neglect, all of which are prevalent in all sports and at all levels. It also covers particularly vulnerable groups of child athletes, including the elite, the disabled, and the LGB (lesbian, gay, bisexual) athlete populations. It covers the many sport organizations working in the field of child athlete protection, as well as the existing statutes governing the rights and freedoms of children in sport.
Feasibility of Hip Fracture Surgery Using a No Transfusion Protocol in Elderly Patients: A Propensity Score-Matched Cohort Study
Authors: Yoon Byung-Ho , Ko Young Seung , Jang Suk-Hwan , Ha Jeong Ku 
Published: April 2017

Objectives:
To determine whether hip fracture surgery (HFS) without transfusion affects postoperative mortality and complications in elderly patients.

Design:
Retrospective comparative study.

Patients:
Three hundred fourteen patients ≥65 years of age who underwent HFS between May 2003 and December 2014. Patients were divided into 2 groups: those who consented to blood transfusion if needed and those who did not. One-to-one propensity score matching generated 50 matched pairs of patients.

Intervention:
Patients underwent HFS with or without blood transfusion. In the no transfusion group, simultaneous administration of erythropoietin and iron was used as an alternative.

Main Outcome Measurements:
The primary outcome was postoperative mortality (90-day, 1-year, overall). The secondary outcomes were hemoglobin change and the incidence of postoperative complications.

Results:
HFS using a no transfusion protocol was not associated with increased mortality at any time point. Mean hemoglobin levels were significantly different between the 2 groups on postoperative day 1 (11.0 ± 1.3 vs. 10.5 ± 1.6, P = 0.002) but levels completely recovered within 2 weeks in both groups. There was also no difference in postoperative complication rates between the 2 groups, and overall hospital stays and charges were similar.

Conclusions:
An HFS protocol without blood transfusion was not associated with increased mortality or complications in elderly patients.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Chemoprophylaxis for Venous Thromboembolism in Operative Treatment of Fractures of the Tibia and Distal Bones: A Systematic Review and Meta-analysis
Authors: Patterson Joseph T. , Morshed Saam 
Published: April 2017

Objectives:
Clinical practice has shifted from therapeutic anticoagulation of any lower extremity venous thromboembolism (VTE) to only thromboses with risk of proximal extension or embolization—clinically important VTE (CIVTE). Isolated operative fractures of the tibia or distal bone of the lower extremity are associated with low-to-intermediate VTE risk, and there is wide variability in the choice to anticoagulate as well as anticoagulant. We sought to evaluate the role for chemoprophylaxis of VTE and CIVTE in these injuries by meta-analysis of Level I evidence.

Data Sources:
Articles in English, Chinese, French, and German in MEDLINE, Biosis, and EMBASE from 1988 to 2016.

Study Selection:
Randomized controlled trials describing chemoprophylaxis of VTE after operative management of fractures of the tibia and distal bones. Independent review of 1502 citations yielded 5 studies (1181 patients) meeting inclusion criteria.

Data Extraction:
Chemoprophylaxis regimen, VTE, CIVTE, and major bleeding events were recorded. Study quality was assessed with regard to randomization, outcome assessment allocation and treatment concealment, and commercial funding.

Data Synthesis:
A random-effects model meta-analysis determined that chemoprophylaxis with a low-molecular-weight heparin (LMWH) compared with placebo or no intervention significantly reduced the risk of any VTE [pooled relative risk (RR) = 0.696, 95% confidence interval (0.490–0.989), P = 0.043; homogeneity P = 0.818, I2 = 0%]. However, chemoprophylaxis with a LMWH compared with placebo did not significantly reduce the risk of CIVTE [RR = 0.865, 95% confidence interval (pooled RR = 0.112–3.863), P = 0.790; homogeneity P = 0.718, I2 = 0%]. No major bleeding events occurred. Funnel plots did not suggest publication bias. The number needed to treat was 31 patients treated with chemoprophylaxis using a LMWH to prevent 1 VTE and 584 patients to prevent 1 CIVTE.

Conclusions:
Meta-analysis of Level I evidence suggests that routine postoperative anticoagulation after surgical management of an isolated fracture of the tibia or distal bone in patients without risk factors for VTE is unlikely to provide a clinical benefit, based on the absence of a treatment effect for preventing VTE warranting therapeutic anticoagulation.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Low-grade Cribriform Cystadenocarcinoma: A Review of the Literature and Case Report
Authors: Wakabayashi Nao , Umezawa Hiroki , Matsumoto Noriko M. , Endo Yoko , Naito Zenya , Ogawa Rei 
Published: April 2017

Summary:Low-grade cribriform cystadenocarcinoma (LGCCC) is a rare tumor of the salivary gland that most often arises from the parotid gland. A 51-year-old man developed a small mass on the right parotid gland 5 years ago. A preoperative magnetic resonance image showed abnormal intensity, an atypical characteristic for such a tumor; therefore, the diagnosis was difficult. Thus, a superficial parotidectomy was performed as a total excisional biopsy to remove the tumor. Histopathological analyses revealed that the tumor was composed of a single cyst comprising cells containing mucosal fluid, with proliferation of large cells. Also, proliferation of the tumor epithelium showed a papillary cribriform pattern of proliferation with a partial ring form, and the tissue inside the tumor was replaced by a hematoma. Mild cellular atypia was observed. Immunostaining for S-100 was positive, and the Ki-67 ratio was <5%. These histopathological findings led to a diagnosis of LGCCC of the parotid gland. At 54 months after surgery, the patient has had no recurrence or facial palsy. LGCCC is a rare neoplasm of the salivary gland and is listed in the current World Health Organization classification (2005) as a variant of cystadenocarcinoma. This case suggests that a thorough preoperative examination can lead to better diagnosis of rare tumors, including LGCCC. Thus, if a plastic surgeon is to correctly diagnose and treat parotid grand tumors, including LGCCC, then a detailed preoperative examination, including imaging, a disease course review, a physical examination, and differential diagnosis, should be considered carefully.
Genetic and environmental factors significant for the presentation and development of inflammatory bowel disease
Authors: Dragasevic Sanja , Stankovic Biljana , Milosavljevic Tomica , Sokic-Milutinovic Aleksandra , Lukic Snezana , Alempijevic Tamara , Zukic Branka , Kotur Nikola , Nikcevic Gordana , Pavlovic Sonja , Popovic Dragan 
Published: April 2017

Objectives
The aim of the study was to evaluate associations between inflammatory bowel disease (IBD) presentation and variants in NOD2, TLR4, TNF-α, IL-6, IL-1β, and IL-RN genes in order to identify possible environmental factors that may affect IBD occurrence, investigate potential predictors for surgical treatment of IBD, and correlate the presence of granulomas in biopsy specimens with clinical characteristics of Crohn’s disease (CD) patients.

Patients and methods
We genotyped 167 IBD patients using PCR-based methodology and tested for disease genotype–phenotype associations.

Results
In CD patients ileal localization of disease was more frequent in NOD2 variant carriers. Ileal CD was associated with IL-6 GC+CC genotypes, identifying C allele as a possible marker of increased risk for ileal CD. In CD patients a positive family history for IBD was related to earlier onset of disease, higher risk for CD-related surgery, and appendectomy. CD patients who are TLR4 299Gly carriers are at higher risk for surgery at onset of the disease compared with TLR4 299Asp variant carriers. The presence of granuloma in biopsy specimens was more frequent in patients in whom a diagnosis of CD was made during emergency surgery. Multivariate analysis showed that CD carriers of the 299Gly allele had a 4.6-fold higher risk for emergency surgery before CD diagnosis is established compared with noncarriers, suggesting an aggressive disease course. Granuloma in endoscopic biopsies is detected 5.4-fold more frequently in patients treated surgically at the time of diagnosis.

Conclusion
Genetic variants together with epidemiological and clinical data of IBD patients could potentially be used as predictors of the disease course.
Duodenal histopathology and laboratory deficiencies related to bone metabolism in coeliac disease
Authors: Posthumus Lotte , Al-Toma Abdul 
Published: April 2017

Objectives
Coeliac disease (CD) is a chronic immune-mediated small intestine enteropathy precipitated by gluten in genetically predisposed individuals. Adult presentation is often atypical and malabsorption of vitamins and minerals is common, with a consequent disturbance of bone metabolism. We aim to evaluate laboratory deficiencies related to bone metabolism and the relationship between severity of histological damage and degree of bone mass loss at diagnosis of CD.

Materials and methods
A retrospective cross-sectional study of 176 adult coeliac patients was carried out. All patients fulfilled the histopathological criteria for CD. Biochemical data were analysed (calcium/phosphate/alkaline-phosphatase/vitamin D/parathormone). Duodenal histology was classified according to the Marsh classification. Bone mass density (BMD) at the lumbar and femoral regions measured by dual X-ray absorptiometry. A P-value of less than 0.05 was considered significant.

Results
No correlation was found between the presence of gastrointestinal symptoms and the Marsh histopathological stage (P>0.05). Vitamin D deficiency was most common (44.5%), whereas only 5.7% had hypocalcaemia. Calcium was lower (P<0.05) and parathormone was higher (P=0.01) in patients with Marsh III. These patients had lower lumbar T-score (P<0.05). Although low BMD occurred in all age groups, most osteoporotic patients were aged 45–49 years (81.8%). A multiple regression analysis showed that the Marsh histopathological stage could be a predictor of lower lumbar BMD (r=0.322, B=−1.146, P<0.05).

Conclusion
Laboratory deficiencies and decreased BMD could be severe and unrelated to the presence of gastrointestinal symptoms. At diagnosis, the Marsh histopathological stage could predict the occurrence of low BMD, which carries a risk of developing into osteoporosis. In coeliac patients older than 30 years, evaluation of bone biomarkers and dual X-ray absorptiometry examination should be considered.
Retinotopic Organization of Scene Areas in Macaque Inferior Temporal Cortex
Authors: Arcaro Michael J. , Livingstone Margaret S. 
Published: April 2017

ABSTRACTPrimates have specialized domains in inferior temporal (IT) cortex that are responsive to particular image categories. Though IT traditionally has been regarded as lacking retinotopy, several recent studies in monkeys have shown that retinotopic maps extend to face patches along the lower bank of the superior temporal sulcus (STS) in IT cortex. Here, we confirm the presence of visual field maps within and around the lower bank of the STS and extend these prior findings to scene-selective cortex in the ventral-most regions of IT. Within the occipito-temporal sulcus (OTS), we identified two retinotopic areas, OTS1 and OTS2. The polar angle representation of OTS2 was a mirror reversal of the OTS1 representation. These regions contained representations of the contralateral periphery and were selectively active for scene vs. face, body, or object images. The extent of this retinotopy parallels that in humans and shows that the organization of the scene network is preserved across primate species. In addition retinotopic maps were identified in dorsal extrastriate, posterior parietal, and frontal cortex as well as the thalamus, including both the LGN and pulvinar. Taken together, it appears that most, if not all, of the macaque visual system contains organized representations of visual space.SIGNIFICANCE STATEMENTPrimates have specialized domains in inferior temporal (IT) cortex that are responsive to particular image categories. Though retinotopic maps are considered a fundamental organizing principle of posterior visual cortex, IT traditionally has been regarded as lacking retinotopy. Recent imaging studies have demonstrated the presence of several visual field maps within lateral IT. Using neuroimaging, we found multiple representations of visual space within ventral IT cortex of macaques that included scene-selective IT cortex. The scene domains were biased towards the peripheral visual field. These data demonstrate the prevalence of visual field maps throughout the primate visual system, including late stages in the ventral visual hierarchy, and support the idea that domains representing different categories are biased towards different parts of the visual field.
Big data in the Danish industry: application and value creation
Authors: Müller Sune Dueholm , Jensen Preben 
Published: April 2017

Purpose
The development within storage and processing technologies combined with the growing collection of data has created opportunities for companies to create value through the application of big data. The purpose of this paper is to focus on how small and medium-sized companies in Denmark are using big data to create value.

Design/methodology/approach
The research is based on a literature review and on data collected from 457 Danish companies through an online survey. The paper looks at big data from the perspective of SMEs in order to answer the following research question: to what extent does the application of big data create value for small and medium-sized companies.

Findings
The findings show clear links between the application of big data and value creation. The analysis also shows that the value created through big data does not arise from data or technology alone but is dependent on the organizational context and managerial action. A holistic perspective on big data is advocated, not only focusing on the capture, storage, and analysis of data, but also leadership through goal setting and alignment of business strategies and goals, IT capabilities, and analytical skills. Managers are advised to communicate the business value of big data, adapt business processes to data-driven business opportunities, and in general act on the basis of data.

Originality/value
The paper provides researchers and practitioners with empirically based insights into how the application of big data creates value for SMEs.
Big data integration with business processes: a literature review
Authors: Fosso Wamba Samuel , Mishra Deepa 
Published: April 2017

Purpose
The purpose of this paper is to improve the understanding of the integration of business process management (BPM), business process re-engineering (BPR) and business process innovation (BPI) with big data. It focusses on synthesizing research published in the period 2006-2016 to establish both what the authors know and do not know about this topic, identifying areas for future research.

Design/methodology/approach
The research is based on a review of 49 published papers on big data, BPM, BPR and BPI in the top journals in the field 2006-2016.

Findings
In this paper, the authors have identified the most influential works based on citations and PageRank methods. Through network analysis the authors identify four major clusters that provide potential opportunities for future investigation.

Practical implications
It is important for practitioners to be aware of the benefits of big data, BPM, BPR and BPI integration. This paper provides valuable insights for practitioners.

Originality/value
This paper is based on a comprehensive literature review, which gives big data researchers the opportunity to understand business processes in depth. In addition, highlighting many gaps in the current literature and developing an agenda for future research, will save time and effort for readers looking to research topics within big data and business processes.