bluuebunny/crossref_metadata_2025_split huggingface dataset:
A melanoma és az agyi áttétképződés molekuláris háttere
Authors: Katona Frida , Murnyák Balázs , Marko-Varga György , Hortobágyi Tibor 
Published: July 2017

Abstract: Malignant melanoma is one of the most aggressive tumors which often gives metastasis to distant organs thereby limiting the chances of survival. Brain metastasis occurs in nearly half of the advanced tumors. In order to improve outcome early diagnosis is important. The discovery and better understanding of genetic and epigenetic changes is essential for developing new effective therapies, which can designate promising therapeutic targets. Melanoma most often is caused by gene mutations of the mitogen-activated protein kinase pathway, the phosphatidylinositol 3-kinase signaling pathway, and the cell cycle regulatory molecules, respectively. The molecular process of brain metastasis has not been fully elucidated. In our review we summarize the genetic alterations and molecular mechanisms playing a role in the development of melanoma and its brain metastasis. Orv Hetil. 2017; 158(28): 1083–1091.
IDENTIFIKASI PERMASALAHAN DAN PELUANG PERBAIKAN PENGEMBANGAN KAWASAN MINAPOLITAN DI KABUPATEN GOWA
Authors: Apriliani Tenny , Kurniawan Tikkyrino , Hikmah Hikmah 
Published: July 2017

Kementerian Kelautan dan Perikanan (KKP) telah menetapkan kebijakan pengembangan kawasan minapolitan di perdesaan. Minapolitan menjadi relevan dengan wilayah pengembangan perdesaan karena pada umumnya sektor perikanan dan pemanfaatan sumberdaya perikanan merupakan mata pencaharian utama dari sebagian besar masyarakat. Penerapan kebijakan ini menghadapi berbagai hambatan dan tantangan dalam pengembangannya. Penelitian ini dilakukan dengan tujuan mengidentifikasi permasalahan yang dihadapi serta peluang perbaikan pengembangan kawasan minapolitan di Kabupaten Gowa. Penelitian dilakukan pada bulan Agustus dan Oktober Tahun 2010. Jenis data yang digunakan berupa data primer dan sekunder. Data yang dikumpulkan diolah dan dianalisa secara deskriptif. Beberapa permasalahan utama yang dihadapi dalam pengembangan minapolitan adalah terkait dengan aspek infrastruktur dan pemasaran. Permasalahan tersebut perlu segera ditindaklanjuti diantaranya berupa perbaikan dan pengadaan infrastruktur seperti irigasi dan jalan serta peran aktif dari pemerintah baik pusat maupun daerah untuk memberikan informasi pasar kepada pembudidaya. Tittle:Identification of Problems and Opportunities for Improving the Minapolitan Area Development in the Regency of GowaMinistry of Marine Affairs and Fisheries (MMAF) has established a policy called Minapolitan in the rural areas development. Minapolitan is relevant to the development of rural areas because in general the fisheries sector and utilization of fishery resources is a major livelihood of most people. Implementation of this policy is facing various obstacles and challenges in its development. Therefore this study was to conducted to identify problems faced and opportunities for improvement in the development MInapolitan in Gowa region. This research was conducted in August and October 2010. Primary and secondary data were used in this study. Data collected were processed and analyzed descriptively. Several major problems faced in the development Minapolitan were related to infrastructure and marketing. The problem need to be immediately followed up in the form of maintaining and developing infrastructure, such as irrigation and roads, and encouraging active role of both central and local government to establish market information to fish farmers.
ANALISIS PENDAPATAN USAHA TANGKAP NELAYAN DAN FAKTOR-FAKTOR YANG MEMPENGARUHINYA DI WILAYAH PESISIR PANTAI SULAWESI SELATAN
Authors: Rahim Abdul 
Published: July 2017

Penelitian yang dilakukan di wilayah pesisir pantai Sulawesi Selatan bertujuan untuk menghitung besarnya perbedaan pendapatan usaha tangkap nelayan dan menganalisis faktor-faktor yang mempengaruhinya. Metode yang digunakan adalah deskriptif dan eksplanatori. Berdasarkan dimensi waktu digunakan data cross-section yang bersumber pada data primer. Responden nelayan diambil secara stratified sampling sedangkan kabupaten secara purposive sampling. Hasil penelitian menemukan bahwa pendapatan usaha tangkap nelayan perahu motor dan perahu tanpa motor di Kabupaten Jeneponto lebih besar dari nelayan Kabupaten Barru dan Sinjai. Besar-kecilnya pendapatan usaha tangkap nelayan perahu motor per trip di wilayah pesisir pantai Sulawesi Selatan dipengaruhi secara positif oleh harga minyak tanah, produktivitas, umur, dan alat tangkap rawai tetap, sedangkan secara negatif dipengaruhi oleh harga bensin, lama melaut, dan perbedaan wilayah penangkapan. Pendapatan nelayan perahu tanpa motor per trip di Sulawesi Selatan dipengaruhi secara positif oleh produktivitas jaring insang tetap dan perbedaan wilayah. Selama setahun, pendapatan nelayan perahu motor dipengaruhi secara positif oleh harga minyak tanah, dan produktivitas secara nyata positif; sedangkan secara negatif dipengaruhi oleh harga bensin, lama melaut, trip, dan perbedaan wilayah. Pendapatan nelayan perahu tanpa motor secara positif dipengaruhi oleh produktivitas, tanggungan keluarga, jaring insang tetap, dan perbedaan wilayah. Tittle: Analysis of Fisher’s Fishing Income and its Various Factors Influence in Coastal Area of South Sulawesi.Research was conducted in coastal area region of South Sulawesi which aimed to calculate the level of difference fisher’s fishing income from each region of coastal area and analysis the various factors influencing it. Research method was used descriptive and explanatory. cross-section data of the primary data. Fisher’s responder were sampled stratifiecally indicate that is fishing income of motorized boat were used and non-motorized boat in regency Jeneponto bigger than is Barru and Sinjai. Then its motorized boat fisher’s fishing income per trip in coastal area of South Sulawesi influenced positively by kerosene price, productivity, age, and set long line, while negatively influenced by gasoline price,fishing day per trip, and difference of fishing areas. Then fishing income non-motorized boat fisher’s per trip in South Sulawesi influenced positively by productivity, set gill net remain to and regional difference. Other only a annual fishing income motorized boat fisher’s influenced positively by kerosene price, and productivity positive manifestly, while negatively influenced by gasoline price, fishing day per trip, number of trip, and fishing area difference. Then fishing income non-motorized boat fisher’s influenced positively by productivity, family responsibility, set gill net, and fishing area difference.
Evaluation of mortality and morbidity in patients with secondary peritonitis using predictive score of mortality in perforated peptic ulcer
Authors: Kumar Navin , Sahu Shantanu Kumar , Bedi Karamjot Singh 
Published: July 2017

Background: Gastrointestinal tract perforation is one of the common surgical emergency all over the world. Menekse et al devised POMPP score (predictive score of mortality in perforated peptic ulcer) to predict the morbidity and mortality in peptic ulcer perforation. The objective of this study was to assess the validity of POMPP score in peptic ulcer perforation and to assess its usefulness in gastrointestinal perforation due to causes other than the peptic ulcer.Methods: Fifty consecutive cases, who had undergone exploratory laparotomy for gastrointestinal perforation peritonitis, were included in the study. “These patients were assessed at the time of admission on the basis of Age >65 years, BUN >45mg/dl (Blood Urea Nitrogen) and Albumin <1.5g/L and a score of 1 point each had been given”. The total score was compared with the outcome of the disease in relation with mortality.Results: In our study, 42% of gastrointestinal perforation were due to peptic ulcer, 22 % due to small bowel perforations (18% Ileal and 4 % Jejunal), 14 % due to trauma and 22 % due to miscellaneous causes. Morbidity is common after gastrointestinal perforation and it ranges from 17-63% whereas mortality ranges from 6-14%.Conclusions: POMPP score is easy and valid scoring system for peptic ulcer perforation. Early detection of high risk peptic perforation cases, allow other supportive treatment modality apart from surgery which can decrease the mortality. However, this score is not valid in perforation due to causes other than peptic ulcer.
EFFECT OF A SHORT PERIOD WHOLE BODY VIBRATION WITH 10 HZ ON BLOOD BIOMARKERS IN WISTAR RATS
Authors: Monteiro Milena de Oliveira Bravo , Sá-Caputo Danúbia da Cunha de , Moreira-Marconi Eloá , Frederico Éric Heleno Freire Ferreira , Sousa-Gonçalves Cintia Renata de , Bernardo Luciana Camargo , Guimarães Carlos Alberto Sampaio , Bernardo-Filho Mario 
Published: July 2017

Background: Exposure to whole body vibration exercises (WBVE), besides some biological effects, causes alterations
in the concentration of some blood biomarkers. The aim of this study is to evaluate the action of vibration (10 Hz) of
WBVE on the concentration of blood biomarkers in Wistar rats.
Materials and Methods: Wistar rats were divided in 2 groups. The experimental group (EG) was subjected to
vibrations of 10Hz (one min per day, one week, total time of seven min), while the control group (CG) has not
experienced vibration. Samples of whole blood were drawn for biochemical analysis of the concentration of total
cholesterol, triglycerides, HDL, LDL, VLDL, glucose, CPK, albumin, alkaline phosphates, TGP, TGO, γGT, lipase,
amylase, urea and creatinine.
Results: White blood cell count and a platelet-hemogram were also performed. Significant (p
ANTI-VIRAL EFFECTS OF MEDICINAL PLANTS IN THE MANAGEMENT OF DENGUE: A SYSTEMATIC REVIEW
Authors: Frederico Éric Heleno Freira Ferreira , Dionísio Cardoso André Luiz Bandeira , Moreira- Marconi Eloá , De Sá-Caputo Danúbia da Cunha , Sampaio Guimarães Carlos Alberto , Fontoura Dionello Carla da , Morel Danielle Soares , Paineiras-Domingos Laisa Liane , De Souza Patricia Lopes , Brandão-Sobrinho-Neto Samuel , Carvalho-Lima Rafaelle Pacheco , Guedes-Aguiar Eliane de Oliveira , Costa-Cavalcanti Rebeca Graça , Kutter Cristiane Ribeiro , Bernardo-Filho Mario 
Published: July 2017

Background: Dengue is considered as an important arboviral disease. Safe, low-cost, and effective drugs that possess
inhibitory activity against dengue virus (DENV) are mostly needed to try to combat the dengue infection worldwide.
Medicinal plants have been considered as an important alternative to manage several diseases, such as dengue. As
authors have demonstrated the antiviral effect of medicinal plants against DENV, the aim of this study was to review
systematically the published research concerning the use of medicinal plants in the management of dengue using the
PubMed database.
Materials and Methods: Search and selection of publications were made using the PubMed database following the
guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA statement).
Results: Six publications met the inclusion criteria and were included in the final selection after thorough analysis.
Conclusion: It is suggested that medicinal plants’ products could be used as potential anti-DENV agents.
Compositional Reservoir-Flow Simulation for Organic-Rich Gas Shale
Authors: Olorode O. M. , Akkutlu I. Y. , Efendiev Y.. 
Published: July 2017

Summary
A new-generation compositional reservoir-flow-simulation model is presented for gas-bearing organic-rich source rocks, including convective/diffusive mass-balance equations for each hydrocarbon component in the organic (kerogen), inorganic, and fracture continua. The model accounts for the presence of dispersed kerogen with sorbed-gas corrected dynamic porosity. The Maxwell-Stefan theory is used to predict pressure- and composition-dependence of molecular diffusion in the formation. The equations are discretized and solved numerically by use of the control-volume finite-element method (CVFEM).
The simulation is derived from a new multiscale conceptual flow model. We consider that kerogen is dispersed at a fine scale in the inorganic matrix and that it will be the discontinuous component of total porosity at the reservoir-simulation scale, which could be up to six orders of magnitude larger. A simple mass-balance equation is introduced to enable kerogen to transfer gas to the inorganic matrix that is collocated in the same gridblock. The convective/diffusive transport takes place between neighboring gridblocks only in the inorganic matrix.
The simulation results show that the multiscale nature of the rock is important and should not be ignored because this could result in an overestimation of the contribution of the discontinuous kerogen. We also observe that although adsorbed fluid could contribute significantly to storage in the shale formation, its contribution to production could be severely limited by the lack of kerogen continuity at the reservoir scale and by a low degree of coupling between the organic and inorganic pores. The contribution of the Maxwell-Stefan diffusion to the overall transport in the shale formation increases as the inorganic matrix permeability is reduced because of pressure decline during production.
ANALISIS KUANTITAS PEMESANAN EKONOMIS DAN SISTEM PRODUKSI TEPAT WAKTU PADA PROSES PERAWATAN ALAT BERAT DI PT. HARITA NICKEL
Authors: Rahim Taufik , Saroso Dana S. 
Published: July 2017

Permasalahan persediaan merupakan konsekuensi yang timbul dari sebuah proses produksi, persediaan berkaitan dengan stock inventory, lead time dan modal investasi untuk persediaan. Penelitian ini bertujuan untuk menganalisa masalah penurunan physical availability equipment yang diakibatkan ketidaktersediaan spare part dan waktu pengiriman yang lama . Jenis penelitian ini adalah deskriptif analistis yang menggambarkan realitas pada obyek yang diteliti secara obyektif dengan menekankan pada variabel ketersediaan alat untuk siap beroperasi, kategori breakdown yang diakibatkan menunggu spare part, dan Lead Time delivery spare part. sedangkan metode yang digunakan adalah mengklasifikasikan spare part (stock class) selanjutnya mengimplementasikan metode EOQ dan JIT . Metode ini merupakan sebuah strategi dan perhitungan yang dilakukan untuk mengetahui jumlah ekonomis spare part yang harus di order dan kapan waktu pengorderan, sedangkan JIT menghasilkan sebuah strategi persediaan yang menghilangkan lead time dan meminimalkan modal investasi awal persediaan dengan kerjasama dengan supplier dan OEM, sehingga service level supplier menjadi baik.
Choreography of the Past: Accounting and the Writing of Christine de Pizan
Authors: Miley Frances , Read Andrew 
Published: July 2017

ABSTRACT

This research discusses The Treasure of the City of Ladies, a manuscript written by Christine de Pizan in France during the early 15th century to give guidance on account keeping and budgeting. Christine de Pizan was born in Italy but raised in the French royal court. Her manuscript gives the keeping of accounts and budget management a religious imperative. She describes them as functions where the three divine virtues of reason, rectitude, and justice are applied. Christine de Pizan describes how demonstrating these virtues through the proper keeping of accounts and budgets is a way to demonstrate love of God. Although historical accounting records show how accounting was done, this manuscript explains why it was done. In giving a rationale for single-entry bookkeeping and budgeting, the manuscript provides a source that prevents present-mindedness when attempting to undertake contemporary analyses of accounting records from this historical period.
Professionalism and Politics in the Procurement Process: United States Civil War Early Years
Authors: Lippman Ellen , McMahon Martin 
Published: July 2017

ABSTRACT

The start of the United States Civil War in 1861 necessitated an increase in the U.S. military force from a population of approximately 16,000 men just prior to the beginning of the war to 700,000 men in less than one year. By the completion of the war four years later, an estimated 2,000,000 soldiers fought for the Union. The dramatic increase in manpower required a rapid response to supply the soldiers with clothing, equipment, and food. This paper analyzes the procurement process and its challenges during the early years of the war, from the initial rush to obtain a large number of supplies when established purchasing procedures were ignored, to the implementation of formalized internal controls and the adoption of the False Claims Act that was used to punish frauds carried out by procurement officers and outside contractors. This paper considers the political influences affecting procurement and finds that politics played only a small role in procurement, although a greater role in oversight of the procurement department.
„jogfosztás” margójára
Authors: Fázsi László , Fedor Anett 
Published: July 2017

Under the topic of long-term criminal processes the study focuses on the role of the defenders, regarding the delays, in connection with Section 275 and 281 of the Criminal Process Code (Act XIX of 1998), amended by the Act CLXXXIII of 2010.
Due to the authors, the misuse of the principle „right of defense”, is one of the significant reasons of the delays in criminal processes. Therefore they agree with the modifications, came into force as of March 1, 2011, which made more difficult to misuse the above mentioned principle. According to the modifications, now it is prohibited to postpone the hearing at the court because, no matter why, the defender could not take part at it.
However, beside the positive evaluation of these modifications, the authors draw the attention of the legislator to the problems arising in the practice when the new rules will be applied. They highlight that the Subsection 3, Section 282 of the Criminal Process Code should have been modified, as well, and further amendments would also be necessary.
It is said that the modifications, either already in force or still to be drafted, are of a high importance, beacause on one hand they warrant that the right of defense would not be misused from this point of view any more, and on the other hand they also support to maintain and ensure the fair criminal process and the attorneys’ respect, further on.
SOFIA/GREAT Discovery of Terahertz Water Masers∗
Authors: Neufeld David A. , Melnick Gary J. , Kaufman Michael J. , Wiesemeyer Helmut , Güsten Rolf , Kraus Alex , Menten Karl M. , Ricken Oliver , Faure Alexandre 
Published: July 2017

Abstract
We report the discovery of water maser emission at frequencies above 1 THz. Using the GREAT instrument on SOFIA, we have detected emission in the 1.296411 THz

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transition of water toward three oxygen-rich evolved stars: W Hya, U Her, and VY CMa. An upper limit on the 1.296 THz line flux was obtained toward R Aql. Near-simultaneous observations of the 22.23508 GHz

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water maser transition were carried out toward all four sources using the Effelsberg 100 m telescope. The measured line fluxes imply 22 GHz/1.296 THz photon luminosity ratios of 0.012, 0.12, and 0.83, respectively, for W Hya, U Her, and VY CMa, values that confirm the 22 GHz maser transition to be unsaturated in W Hya and U Her. We also detected the 1.884888 THz

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transition toward W Hya and VY CMa, and the 1.278266 THz

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transition toward VY CMa. Like the 22 GHz maser transition, all three of the THz emission lines detected here originate from the ortho-H2O spin isomer. Based upon a model for the circumstellar envelope of W Hya, we estimate that stimulated emission is responsible for ∼85% of the observed 1.296 THz line emission, and thus that this transition may be properly described as a terahertz-frequency maser. In the case of the 1.885 THz transition, by contrast, our W Hya model indicates that the observed emission is dominated by spontaneous radiative decay, even though a population inversion exists.
Changing trend in bacterial etiology and antibiotic resistance in sepsis of intramural neonates at a tertiary care hospital
Authors: Roy MP , Bhatt M , Maurya V , Arya S , Gaind R , Chellani HK 
Published: July 2017

Background:
Septicemia is an important cause of neonatal morbidity and mortality. However, organized data on causative organisms and their resistant pattern are scanty from developing countries. The changing trend in causative organisms and their antibiotic resistance is yet to be documented in India. The present study examines the trends in bacterial profile and antibiotic resistance of the organisms causing sepsis in hospitalized neonates.

Materials and Methods:
A retrospective laboratory-based analysis of blood cultures obtained from Neonatal Intensive Care Unit of a tertiary care hospital in New Delhi was done for the period of 1999–2014, divided into five phases.

Results:
A total of 4700 isolates were considered. Over time, Gram-negative organisms have replaced Gram-positives as frequent isolates. Initially, there was predominance of Klebsiella pneumoniae, then of Staphylococcus aureus which recently has been changed with coagulase negative-Staphylococcus and Acinetobacter. Growing resistance against the first and second line of drugs has been noted, including methicillin-resistant S. aureus and vancomycin-resistant Enterococcus.

Conclusion:
The etiological profile of neonatal sepsis has changed tremendously in the past 15 years. High resistance against common drugs necessitates continued surveillance and review of empirical antibiotic policy for neonatal sepsis. These steps are important to effectively curtail the surge of further antibiotic resistance.
Deranged regulatory T-cells and transforming growth factor-β1 levels in type 1 diabetes patients with associated autoimmune diseases
Authors: Kaur N , Minz RW , Bhadada SK , Dayal D , Singh J , Anand S 
Published: July 2017

Aim:
This study was designed to enumerate regulatory T-cells (Tregs) and estimate transforming growth factor-β1 (TGF-β1) levels in type 1 diabetic (T1D) patients with respect to disease duration and associated autoimmune diseases.

Methods:
One hundred and fifty patients and twenty healthy controls were recruited in the study. The patients were subcategorized into eight categories on the basis of disease duration (new onset [NO] and long standing [LS]) and associated diseases, i.e., celiac disease (CD) and autoimmune thyroid disease (AiTD). Treg cells were assessed as CD4+ CD25hi+, FOXP3+ cells and serum TGF-β1 levels were assessed by ELISA.

Results:
The frequency of Tregs and levels of TGF-β1 were significantly increased in the patients compared to the healthy controls. Among the different categories of the patients, no significant differences were seen for TGF- β1 levels, but for Tregs in patients with T1D and AiTD (P = 0.035). A significant correlation was also found between percentage count of Tregs and TGF-β1 levels in NO cases in all disease subcategories, but not in LS patients.

Conclusion:
Thus, there was an increased percentage of Tregs and serum levels of TGF-β1 in T1D patients, irrespective of the disease duration and associated autoimmune diseases. The significant correlation in these two parameters at the onset of the disease, but not in LS disease, indicates that the immunological milieu in LS autoimmune diseases is more complicated with disease-associated conditions such as prolonged hyperglycemia, insulin therapy, and/or continued gluten in diet. Treatment and modulation of these long-term complications for improving immunological parameters require further research.