bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of Chemotherapy Treatments for Breast Cancer Patients at Bhayangkara Tk.1 Pudsdokkes Polri Hospital, Jakarta
Authors: Febriani Amelia , Pujiastuti Fitria , Teodhora Teodhora 
Published: September 2024

Background: Breast cancer is a malignant breast tumor that develops in the ductal or lobular epithelium and usually attacks women. Chemotherapy is a cornerstone of breast cancer treatment, particularly for patients with advanced disease or those who are not candidates for surgery or radiation therapy. This research aims to observe the use of chemotherapy drugs for breast cancer patients in terms of chemotherapy regimens and cycles at Bhayangkara Tk.1 Pudsdokkes Polri Hospital. Methods: This study employs descriptive quantitative approaches. Data were gathered retrospectively from medical records of breast cancer patients receiving chemotherapy at Bhayangkara Tk.1 Pudsdokkes Polri Hospital Jakarta from July to December 2021. Results: From 110 patients, 86 (78.18%) patients used the CAF regimen, 18 (16.36%) patients used the AC regimen, and 3 (2.73%) patients used the TAC regimen, while the regimen that did not comply with the guidelines was 2 (1.82%) patients using the combination of paclitaxel and epirubicin, 1 patient utilizing the combination of paclitaxel and doxorubicin. Forty-six (41.82%) patients with the CAF regimen had completed six cycles of chemotherapy with intervals of 3 weeks or 21 days, while only 5 patients (3.63%) completed four cycles of the AC regimen at 3-week or 21-day intervals. At the time of data collection, 11 patients, and 1 patient utilizing the AC regimen. This was because 59 patients had not yet finished the chemotherapy cycle, specifically in the advanced stage. Conclusions: The CAF regimen was the most commonly used chemotherapy regimen, followed by the AC and TAC regimens. This finding aligns with current clinical guidelines for breast cancer treatment. A significant number of patients had not yet completed their chemotherapy cycles, particularly those with advanced-stage breast cancer. This highlights the challenges associated with treating advanced disease and the need for more effective and less toxic treatment options.
Characterization of Classic Meningioma with Use of Conventional Magnetic Resonance and Diffusion Tensor Imaging
Authors: Fatmawati Heni , Adji Novan Krisno , Bumi Candra , Putri Komang Yunita Wiryaning 
Published: September 2024

Introduction: The conventional magnetic resonance imaging (MRI) method is widely considered ‘with limited success’ in differentiating the meningioma types but may fail to localize the tumor occupation of white-matter fiber bundles accurately. Diffusion tensor imaging (DTI) is considered as an imaging modality that may elucidate the microstructure of brain tumors. We provide characteristics of meningioma using DTI-based-three-dimensional tracing of white matter to portray meningioma in a noninvasive approach and its structural contact to contiguous tumors and elucidate the influence of occupying lesions on white-matter fiber bundles. Case Presentation: A 28-year-old female presented with visuospatial disturbances and persistent headaches for 2 years. Conventional and advanced MRI studies were performed. Diffusion-weighted Images (DWI) and Apparent Diffusion Coefficient (ADC) values were measured in the lesion using routine MRI sequences. Advanced MRI using DTI was also performed. Conventional MRI outcomes showed tumor parenchyma, peritumoral edema, and compression on the circumnavigated brain tissue. There was hyperintense on DW trace image and isointense on ADC map. On T2-weighted image (T2WI) and Fluid-Attenuated Inversion Recovery (FLAIR) images, there was an increased signal intensity that demonstrated an extra-axial lesion, while T1-weighted imaging signals showed hypointensity. DTI fractional anisotropy (FA) marker is an unclear optic radiation in the concerned area, indicating the shift or destruction of the optic radiation. The mean FA values of solid-enhancing areas of meningioma were 0.28 ± 0.17. Mean ADC values (103 mm2/s) were 0.764 ± 0.172. Conclusions: Classic meningioma in this case has low intratumoral FA and high ADC. DTI displayed that intratumoral microscopic water motion is disorganized.
Exogenous Reactive Oxygen Species Augments SMAD4 Expression And TGF-β Paradox in Human Breast Cancer
Authors: Roy Avany Vinod , Padmanabhan Renjini Ambika , Ramachandran Rajesh 
Published: September 2024

Background: The Transforming growth factor-β (TGF-β) functions to induce apoptosis, cell cycle arrest, and differentiation is central to sustaining tissue homeostasis and maintaining genomic stability. TGF-β normally, an effective tumor-suppressor that restricts the uncontrolled division of cells augments the development and progression of human malignancies when cytostatic activities of TGF-β are resisted by genetic and epigenetic events caused by tumorigenesis. This dichotomic nature of TGF-β during oncogenesis termed as “TGF-β Paradox,” persists to be the most crucial and puzzling query regarding its physio-pathological function and the role of cellular antioxidant status is highly interrelated which warrants more studies on the role of endogenous reactive oxygen species (ROS) in deciding epithelial-mesenchymal transition (EMT) process. The objective of the study was to check whether enhanced ROS augments the TGF-β pathway facilitating EMT. Methods: In vitro toxicity assay was performed to assess the appropriate concentration of hydrogen peroxide (H2O2) imparting oxidative stress. Comet assay and 8-OHdG (8-hydroxy-2’-deoxyguanosine) enzyme-linked immunosorbent assay (ELISA) were performed to check the extent of DNA damage and adduct production respectively. Mitogen-activated protein kinase (MAPK) p38 ELISA and mRNA gene expression analysis of TGF-β and SMAD were done to verify the effect of H2O2 on these signaling. Results: The objective of the study was to check whether enhanced ROS augments the TGF-β pathway facilitating EMT. Along with morphological alterations, a dose-dependent decrease in cell viability was seen at 300µM of H2O2 compared to 75µM. DCFDA labeling discovered the dose-dependent gradation of intracellular ROS generation and this was correlated to increased cellular DNA damage and DNA adduct production which was increased linearly with increasing H2O2 as evident with comet test and 8-OHdG ELISA. Significantly reduced MAPK p38 activity revealed by indirect ELISA analysis suggests lessened suppression of cell growth. Conclusions: The study establishes that higher intracellular ROS will facilitate the TGF-β paradox leading to epithelial mesenchymal transition which can adversely affect therapeutic strategies targeting EMT
Epidural Analgesia for Palliative Pain Management for A Patient with An Advanced Stage Prostate Cancer: A Case Report
Authors: Susilo Astrid Pratidina , Pryambodho Pryambodho 
Published: September 2024

Introduction: Patients with advanced-stage cancer should be able to stay at home with their families without suffering from pain. This case report aims to discuss challenges in pain management of a patient with bone metastasis of prostate cancer who received epidural analgesia at home. Challenges were related to the patients, health professionals, and system. Understanding each factor will bring insights to develop a workable pain management program in the palliative setting. Case Presentation: A 66-year-old male was diagnosed with left sacroiliac joint pain due to metastatic prostate cancer. After a three-year history of prostate cancer and ineffective chemotherapy, the patient complained of pain in the left hip that did not improve with conventional medications (paracetamol, tramadol, and Morphine Sustained Release/MST). In response, the consideration of an epidural implant emerged as a potential solution, offering the prospect of home-based care and autonomous medication administration through an epidural continuous block with intermittent drug injection. Conclusions: This case highlights home-based interventional pain management for cancer, addressing challenges at the patient, health professional, and system level. Overcoming these challenges requires a multidisciplinary approach and robust institutional policies. The insights gained offer valuable lessons for hospitals aiming to enhance the competence of pain and palliative care teams and establish comprehensive support systems in hospital and home settings.
The Role of Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma Patients: A Literature Review
Authors: Giselvania Angela , Sekarutami Sri Mutya , Munandar Arie , Halim Devina Adella , Wijovi Felix 
Published: September 2024

Background: Globally, hepatocellular carcinoma (HCC) is the most prevalent kind of primary liver cancer. Treatment options for HCC include radiotherapy, immunotherapy, surgery, targeted therapy, transarterial chemoembolization, and hepatic arterial infusion chemotherapy. Limited efficacy was observed since 70-80% of cases are diagnosed late and unresectable. Growing evidence reported that SBRT is a viable option for locoregional treatments like radiofrequency ablation (RFA) or transarterial chemoembolization (TACE) for patients who did not respond to those treatments. Methods: A thorough search of electronic databases including PubMed, Cochrane Library, and Embase was conducted for studies on Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma published in English over the past 10 years. The review process followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to ensure a systematic approach. Inclusion criteria encompassed studies focusing on SBRT use in HCC treatment, with extracted data synthesized to provide a comprehensive overview of current evidence. Any discrepancies during the review were resolved through consultation with a third reviewer when necessary. Results: In comparison to conventional radiation therapy, Stereotactic Body Radiation Therapy (SBRT) offers precise administration of the high dose of radiotherapy, given in fewer fractions, and may be used in conjunction with other therapy modalities. Global guidelines, including in Indonesia, have proposed the implementation of SBRT. Local control was reportedly achieved in around 90–95% of HCC patients. Multimodal therapies, combined with TACE, showed superior results regarding the local control and overall survival. SBRT may eventually become the definitive treatment for early-stage HCC patients and has a critical role as a transitional therapy for patients awaiting liver transplantation. Improved outcomes and quality of life were also observed in patients with portal vein thrombosis (PVT) and extrahepatic metastases who underwent SBRT. Conclusions: SBRT results in promising local control, raises overall survival, and improves the quality of life in HCC patients with various stages.
HALP and PNI Score as Predictors of Nutritional Status in the Incidence of Incisional Hernia after Laparotomy in Colorectal Cancer Patients: A Case-Control Study
Authors: Nurasti Wawan Suci , Handaya Adeodatus Yuda , Barmawi Agus , Anwar Sumadi Lukman 
Published: September 2024

Background: Colorectal cancer ranks as the third most common cancer in the world. If patients can still be resected, surgical therapy is carried out. An incisional hernia is one of the complications after laparotomy surgery. Nutritional status can influence the incidence of incisional hernias after laparotomy. Colorectal cancer patients must have their nutritional status assessed using a simple scoring. This research aims to evaluate Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) and Prognostic Nutritional Index (PNI) scores as a predictor of incisional hernia after laparotomy surgery in colorectal cancer patients at Dr. Sardjito General Hospital, Yogyakarta. Methods: This study uses a case-control study design which consisted of two groups, a case group of colorectal cancer patients with incisional hernias after laparotomy surgery and a control group of colorectal cancer patients without incisional hernias. The independent variable was nutritional status which was assessed by HALP and PNI score, and the dependent variable was incisional hernia. This research by taking data from laboratory patients at Dr. Sardjito General Hospital, Yogyakarta. For multivariate analysis, a logistic regression test was used with a significance value of p 0.05. Results: There is a relationship between the stage of cancer and the comorbid diabetes mellitus with the incidence of incisional hernias after laparotomy, this can be seen in the results of the chi-square test. Advanced stage has an OR of 13 (P=.001; OR=13; 95% CI 3.551-47.597), while comorbid diabetes mellitus has an OR of 6.571 (P=.002; OR=6.571; 95% CI 2.109-20.479). However, there is no correlation between the HALP and PNI score with the incidence of incisional hernia after laparotomy. The multivariate analysis results in HALP score have a significant correlation between the nutritional status and the incidence of incisional hernia with OR=17.981 (p= 0.037 OR=17; 95% CI 1.198-269.803). Conclusions: The HALP score can be used as a screening predictor in the incidence of incisional hernia after laparotomy for colorectal cancer patients.
Educação Inclusiva no ensino de Ciências e Biologia: Uma perspectiva a partir da formação docente
Authors: Viana Rosângela Silva de Araújo , Almeida Delma Holanda de 
Published: September 2024

O artigo apresenta uma análise sobre a educação inclusiva no ensino de Ciências e Biologia, contextualiza historicamente o desenvolvimento da educação inclusiva no Brasil e internacionalmente, destacando marcos como a criação de instituições para pessoas com deficiência e a influência de documentos como a Declaração Universal dos Direitos Humanos e a Lei de Diretrizes e Bases da Educação Nacional. O estudo enfatiza a importância da participação ativa dos alunos no processo de aprendizagem, com ênfase na formação docente como elemento-chave para promover uma educação inclusiva. A metodologia adotada envolve uma revisão bibliográfica qualitativa, tendo o objetivo de buscar artigos relacionados à formação de professores de Ciências/Biologia na perspectiva da educação inclusiva. Os resultados e discussão destacam a importância das disciplinas de Ciências e Biologia no currículo escolar e a necessidade de adaptar as práticas de ensino para atender às necessidades individuais dos alunos, especialmente aqueles com deficiência. São abordados desafios enfrentados pelos educadores, como a falta de formação inicial em educação inclusiva e a escassez de recursos didáticos adequados. A formação contínua dos professores é ressaltada como fundamental para superar esses obstáculos e promover uma prática pedagógica mais eficaz e inclusiva. A pesquisa destaca também a dimensão política da educação e a importância de promover debates abrangentes e contínuos sobre a inclusão escolar. Em suma, o artigo enfatiza a urgência de adotar abordagens inclusivas e adaptativas para garantir uma educação de qualidade para todos, reconhecendo a necessidade de esforços coletivos para alcançar esse objetivo.
ON TOPICAL PROBLEMS OF THE MODERN SCHOOL: TEACHERS’ OPINION IN THE KOSTROMA REGION
Authors: Belova Natalia A.  
Published: September 2024

This article presents the findings of a survey among school teachers conducted in Kostroma between April and May 2024. The objective of the study was to ascertain the level of satisfaction with their profession among teachers and to identify the most significant challenges they face in their work. The concerns expressed by the respondents could be grouped into the following categories: low income and low salaries, excessive teaching workload and a lack of free time; insufficient material and technical resources in schools in the region; and weak moral incentives for teachers. The results of the survey indicate that, in addition to financial concerns, teachers are also dissatisfied with the decline in their authority and status within society. Furthermore, the survey demonstrated that the material aspect is a significant but not a primary source of discontent among teachers. Their social status, which does not align with their qualifications, is a notable concern. It is also important that in underprivileged regions, the shortage of personnel has intensified, particularly in mathematics and the Russian language. Based on statistical data, media reports, and field observations, there seems to be a reluctance among young individuals to pursue careers in education. The teachers who participated in the survey reached a unanimous consensus on the necessity of implementing measures to enhance the material well-being of educators, upgrade the material and technical infrastructure of educational institutions, and reinstate the esteemed status of teaching professionals in society.
A dynamically loaded ex vivo model to study neocartilage and integration in human cartilage repair
Authors: Trengove Anna , Caballero Aguilar Lilith M. , Di Bella Claudia , Onofrillo Carmine , Duchi Serena , O’Connor Andrea J. 
Published: September 2024

Articular cartilage injuries in the knee can lead to post-traumatic osteoarthritis if untreated, causing debilitating problems later in life. Standard surgical treatments fail to ensure long lasting repair of damaged cartilage, often resulting in fibrotic tissue. While there is a vast amount of research into cartilage regeneration, integrating engineered implants with cartilage remains a challenge. As cartilage is a load bearing tissue, it is imperative to evaluate tissue repair strategies and their ability to integrate under mechanical loading. This work established a dynamically loaded ex vivo model of cartilage repair using human cartilage explants. The model was used to assess the efficacy of a stem cell therapy delivered in a bioadhesive hydrogel comprised of photocrosslinkable gelatin methacryloyl (GelMA) and microbial transglutaminase to repair the model defect. Extensive neocartilage production and integration were observed via histology and immunohistochemistry after 28 days chondrogenic culture. Analysis of culture media allowed monitoring of glycosaminoglycan and type II collagen production over time. A mechanical assessment of integration via a push out test showed a 15-fold increase in push out strength over the culture duration. The model was successful in exhibiting robust chondrogenesis with transglutaminase or without, and under both culture conditions. The work also highlights several limitations of ex vivo models and challenges of working with bioreactors that must be overcome to increase their utility. This ex vivo model has the potential to delay the need for costly pre-clinical studies and provide a more nuanced assessment of cartilage repair strategies than is possible in vivo.
Synthesis of the modified SBA-15 mesoporous silica with TAN ligand to preconcentrate and determine trace amounts of Ni (II) ions in water and wastewater samples
Authors: Amouzad Mahdirajeh Taha , Mirabi Ali , Habibi Juybari Mohammad , Zafar Mehrabian Ramin , Jalilian Hamid Reza 
Published: September 2024

The synthesis of modified mesoporous silica (SBA-15), a powerful and highly effective adsorbent, was provided for the preconcentration, extraction, separation, and determination of trace amounts of Ni (II) ions. In this method, SBA-15 modified with 1-(2-thiazolylazo)-2-naphthol (TAN) was used as a suitable absorbent. The absorption of Ni (II) ions was studied using the FAAS technique. Transmission electron microscopy (TEM), thermogravimetric analysis (TGA), Brunauer–Emmett–Teller (BET), energy-dispersive spectroscopy (EDS), Fourier-transform infrared (FT-IR) spectroscopy, and CHNS elemental analysis techniques were used to assess the characteristics of SBA-15 and TAN/SBA-15. Effective parameters (pH, amount of nanocomposite, extraction time, and type of recovery solvent) for extracting Ni (II) ions via TAN/SBA-15 were investigated. The merit figures of the method were obtained with appropriate results, such as detection limit, accuracy, enrichment factor, and preconcentration factor. The calibration curve was linear within the range of 5.0–50 ng mL-1 with a detection limit of 1.8 ng mL-1. High preconcentration, small relative standard deviations, and enrichment factors (approximately 100) were represented by the statistical analysis. The proposed method for measuring Ni (II) ions was used at trace levels in real samples, such as seawater, river water, well water, and wastewater from a textile factory, an electrical power station, an MDF factory, and a food industrial company, with satisfactory results.
Risk factors and predictive model for nosocomial infections by extensively drug-resistant Acinetobacter baumannii
Authors: Shi Jingchao , Mao Xiaoting , Cheng Jianghao , Shao Lijia , Shan Xiaoyun , Zhu Yijun 
Published: September 2024

BackgroundExtensively drug-resistant Acinetobacter baumannii (XDRAB) has become a significant pathogen in hospital environments, particularly in intensive care units (ICUs). XDRAB’s resistance to conventional antimicrobial treatments and ability to survive on various surfaces pose a substantial threat to patient health, often resulting in severe infections such as ventilator-associated pneumonia (VAP) and bloodstream infections (BSI).MethodsWe retrospectively analyzed clinical data from 559 patients with XDRAB infections admitted to Jinhua Central Hospital between January 2021 and December 2023. Patients were randomly divided into a training set (391 cases) and a testing set (168 cases). Variables were selected using Lasso regression and logistic regression analysis, and a predictive model was constructed and validated internally and externally. Model performance and clinical utility were evaluated using the Hosmer-Lemeshow test, C-index, ROC curve, decision curve analysis (DCA), and clinical impact curve (CIC).ResultsLasso regression analysis was used to screen 35 variables, selecting features through 10-fold cross-validation. We chose lambda.1se=0.03450 (log(lambda.1se)=-3.367), including 10 non-zero coefficient features. These features were then included in a multivariate logistic regression analysis, identifying 8 independent risk factors for XDRAB infection: ICU stay of 1-7 days (OR=3.970, 95%CI=1.586-9.937), ICU stay &gt;7 days (OR=12.316, 95%CI=5.661-26.793), hypoproteinemia (OR=3.249, 95%CI=1.679-6.291), glucocorticoid use (OR=2.371, 95%CI=1.231-4.564), urinary catheterization (OR=2.148, 95%CI=1.120-4.120), mechanical ventilation (OR=2.737, 95%CI=1.367-5.482), diabetes mellitus (OR=2.435, 95%CI=1.050-5.646), carbapenem use (OR=6.649, 95%CI=2.321-19.048), and β-lactamase inhibitor use (OR=4.146, 95%CI=2.145-8.014). These 8 factors were used to construct a predictive model visualized through a nomogram. The model validation showed a C-index of 0.932 for the training set and 0.929 for the testing set, with a Hosmer-Lemeshow test p-value of 0.47, indicating good calibration. Furthermore, the DCA curve demonstrated good clinical decision-making performance, and the CIC curve confirmed the model’s reliable clinical impact.ConclusionRegression analysis identified ICU stay duration, hypoproteinemia, glucocorticoid use, urinary catheterization, mechanical ventilation, diabetes mellitus, carbapenem use, and β-lactamase inhibitor use as independent risk factors for XDRAB infection. The corresponding predictive model demonstrated high accuracy and stability.