bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sentinel visits in emergency department patients with diabetes mellitus as a warning sign for hyperglycemic emergencies
Authors: Yan Justin W. , Gushulak Katherine M. , Columbus Melanie P. , Hamelin Alexandra L. , Wells George A. , Stiell Ian G. 
Published: July 2017

ABSTRACTObjectivesPatients with poorly controlled diabetes mellitus may have a sentinel emergency department (ED) visit for a precipitating condition prior to presenting for a hyperglycemic emergency, such as diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS). This study’s objective was to describe the epidemiology and outcomes of patients with a sentinel ED visit prior to their hyperglycemic emergency visit.MethodsThis was a 1-year health records review of patients≥18 years old presenting to one of four tertiary care EDs with a discharge diagnosis of hyperglycemia, DKA, or HHS. Trained research personnel collected data on patient characteristics, management, disposition, and determined whether patients came to the ED within the 14 days prior to their hyperglycemia visit. Descriptive statistics were used to summarize the data.ResultsOf 833 visits for hyperglycemia, 142 (17.0%; 95% CI: 14.5% to 19.6%) had a sentinel ED presentation within the preceding 14 days. Mean (SD) age was 50.5 (19.0) years and 54.4% were male; 104 (73.2%) were discharged from this initial visit, and 98/104 (94.2%) were discharged either without their glucose checked or with an elevated blood glucose (>11.0 mmol/L). Of the sentinel visits, 93 (65.5%) were for hyperglycemia and 22 (15.5%) for infection. Upon returning to the ED, 61/142 (43.0%) were admitted for severe hyperglycemia, DKA, or HHS.ConclusionIn this unique ED-based study, diabetic patients with a sentinel ED visit often returned and required subsequent admission for hyperglycemia. Clinicians should be vigilant in checking blood glucose and provide clear discharge instructions for follow-up and glucose management to prevent further hyperglycemic emergencies from occurring.
Collateral Scoring on CT Angiogram Must Evaluate Phase and Regional Pattern
Authors: Casault Colin , Al Sultan Abdulaziz S. , Trivedi Anurag , Sohn Sung Il , Qazi Emmad , Bokyo Matthew , Almekhlafi Mohammed , d’Esterre Christopher , Goyal Mayank , Demchuk Andrew M. , Menon Bijoy K. 
Published: July 2017

AbstractPurpose: We measured anterior cerebral artery (ACA)-middle cerebral artery (MCA) and posterior cerebral artery (PCA)-MCA pial filling on single-phase computed tomography angiograms (sCTAs) in acute ischemic stroke and correlate with the CTA-based Massachusetts General Hospital (MGH) and digital subtraction angiography (DSA)-based American Society of Interventional and Therapeutic Neuroradiology (ASITN) score. Methods: Patients with acute stroke and M1 MCA±intracranial internal carotid artery occlusion on baseline CTA were included. Baseline sCTA was assessed for phase of image acquisition. An evaluator assessed collaterals using the Calgary Collateral (CC) Score (measures pial arterial filling in ACA-MCA and PCA-MCA regions separately), the CTA-based MGH score, and on DSA using the ASITN score. Infarct volumes were measured on 24- to 48-hour magnetic resonance imaging/ computed tomography. Results: Of 106 patients, baseline sCTA was acquired in early arterial phase in 9.9%, peak arterial in 50.7%, equilibrium in 32.4%, early venous in 5.6%, and late venous in 1.4%. Variance in ACA-MCA collaterals explained only 32% of variance in PCA-MCA collaterals on the CC score (Spearman’s correlation coefficient rho [rho]=0.56). Correlation between ACA-MCA collaterals and the MGH score was strong (rho=0.8); correlation between PCA-MCA collaterals and this score was modest (rho=0.54). Correlation between ACA-MCA collaterals and the ASITN score was modest (n=53, rho=0.43); and correlation between PCA-MCA collaterals and ASITN score was poor (rho=0.33). Of the CTA-based scores, the CC Score (Akaike [AIC] 1022) was better at predicting follow-up infarct volumes than was the MGH score (AIC 1029). Conclusion: Collateral assessments in acute ischemic stroke are best done using CTA with temporal resolution and by assessing regional variability. ACA-MCA and MCA-PCA collaterals should be evaluated separately.
Analysis of a Rotating Disk System with Axial Cooling Air
Authors: Jiao Z. , Fu S. , Kawakubo T. , Ohuchida S. , Tamaki H. 
Published: July 2017

AbstractIn this article, a series of simulations of a rotating disk system with air cooling is introduced. These simulations are performed with the realizable k-ε eddy-viscosity model. Computational results illustrate the effect of the cooling air and disk rotation on the temperature of the disk surface. The maximum rotating disk speed reaches about 78300 rpm and the range of Reynolds numbers based on rotation speed is from about 0.7 × 106to 3 × 106. The present work shows that the flow structure in the gap, which is on the opposite side of the cooling air, is rather similar to different cooling air flows. The temperature goes up as the rotating speed increases. The temperature in this gap will first decrease when the cooling air increases under lower mass flow rate. But when the cooling air continues to increase, the temperature will rise up indicating the existence of an optimum value of the cooling flow rate.
Social network and temporal discounting
Authors: BURT RONALD S. 
Published: July 2017

AbstractFor reasons of social influence and social logistics, people in closed networks are expected to experience time compression: The more closed a person's network, the steeper the person's discount function, and the more narrow the expected time horizon within which the person deliberates events and behavior. Consistent with the hypothesis, data on managers at the top of three organizations show network closure associated with a social life compressed into daily contact with colleagues. Further, language in closed networks is predominantly about current activities, ignoring the future. Further still, discount functions employed by executive MBA students show more severe discounting by students in more closed networks. Inattention to the future can be argued to impair achievement, however, I find no evidence across the managers of daily contact diminishing the achievement associated with network advantage. I close with comments on replication and extrapolation to language more generally, within-person variation, and select cognitive patterns (closure bias, end of history, and felt status loss).
Antarctic snow melt detection based on the synergy of SSM/I and QuikSCAT
Authors: Li Xinwu , Wang Xingdong , Wang Cheng , Zhang Lu 
Published: July 2017

AbstractMicrowave radiometer SSM/I (Special Sensor Microwave Imager) data and scatterometer QuikSCAT (Quick Scatterometer) data have been widely used for near-surface snow melt detection based on their sensitivity to liquid water present in snow. The SSM/I data have high reliability and the QuikSCAT data have high spatial resolution. In order to improve the accuracy of Antarctic near-surface snow melt detection, we propose a new method based on the synergy of SSM/I and QuikSCAT data, i.e. the snow melt physical model incorporates the complementary advantages of both datasets. Based on comparisons with temperature data from three automatic weather stations, the proposed algorithm improved the accuracy of snow melt detection. The algorithm could also be applied to other regions, which would provide further evidence to support its use and additional data to document changes in the Antarctic due to global climate change.
Uh, bueno, em… : Filled pauses as a site of contact-induced change in Boston Spanish
Authors: Erker Daniel , Bruso Joanna 
Published: July 2017

AbstractThere is mounting evidence that the filled pauses that pervade spontaneous speech constitute a rich site of linguistic inquiry. The present study uses a comparative variationist method to explore possible effects of language contact on pause behavior, examining 3810 filled pauses produced by 24 Spanish-speaking residents of Boston, Massachusetts. Interspeaker differences in pause behavior correlate with intensity of contact. Participants who have lived in the United States for a larger fraction of their lives, who use English more frequently, and who do so more proficiently fill pauses differently when speaking Spanish than do those who have spent less time in the contact setting and whose English skills and usage are more restricted. Results show that a greater degree of contact corresponds to increased use of centralized vowels in phonologically filled pauses (i.e., more frequent use of [a(m)] and [ə(m)] at the expense of [e(m)]). This pattern is interpreted as evidence of contact-induced change.
Large changes in the avifauna in an extant hotspot of farmland biodiversity in the Alps
Authors: KORNER PIUS , GRAF ROMAN , JENNI LUKAS 
Published: July 2017

SummaryLarge declines of farmland bird species have been observed in the lowlands of Western Europe, whereas important populations of some of these species have survived in parts of Eastern and Southern Europe and in small areas within Western Europe, e.g. in parts of the Alps. However, such extant hotspots of farmland biodiversity are at risk: The economic and technical developments threaten to erode biodiversity in existing hotspots, potentially repeating the collapse previously observed in Western Europe. We here present changes in the abundance of farmland birds in the Engadin in the Swiss Alps. Farmland birds such as WhinchatSaxicola rubetraand SkylarkAlauda arvensiswere still numerous in 1987/1988 when we first censused the area. During our second census period in 2009/2010, we noticed strong declines of such open country species, while several hedge and tree breeders as well as some species preferring warmer climate increased. We observed a good correlation between the change in the vegetation and in the birds. Both these changes were especially pronounced in areas with a recent agricultural improvement project. Thus, we believe that the change in farmland practices, which affected our mountainous study area much later than the lowlands, and possibly climate change, have led to a profound change in the regional avifauna. Using our data as a case study, we argue that similar, and similarly fast, changes may be on-going or imminent in many other areas with extant important populations of farmland species such as Whinchat and Skylark. Thus, our data add to the repeatedly declared urgency to adjust the advancement of agricultural subsidy systems to better accommodate biodiversity considerations, both in depauperated areas as well as in extant hotspots.
Unsettling Brian Eno'sMusic for Airports
Authors: SZABO VICTOR 
Published: July 2017

AbstractIn the liner notes to his albumAmbient 1: Music for Airports(1978), Brian Eno (1948–) defined Ambient music in contradistinction to Muzak's ‘derivative’ instrumental pop arrangements. Ambient music's historians and critics have often followed Eno by describing Ambient music as an alternative to conventional ‘background’ or ‘programmed’ music for commercial spaces. Such descriptions can be misleading, however, given that Ambient music's dominant mode of reception is selective personal consumption, not public administration. This article investigates the aesthetics of Eno'sAirports, and elucidates the organizing role of the Ambient genre, within their primary reception context of personal recorded music listening. A comparison with The Black Dog'sMusic for Real Airports(2010) shows how Ambient music then and now reflexively affords atmospheric use by translating a sense of physical dwelling and passage into mixed musical moods. By expressing ambivalenceaboutthe reality of airports and air travel, these Ambient records characteristically convey apprehension about the technological administration of human experience – a phenomenon that includes personal recorded music listening.
Functional Detection of TNF Receptor Family Members by Affinity-Labeled Ligands
Authors: Xu Yang , Chang Lingmo , Huang Anliang , Liu Xiaojun , Liu Xinyu , Zhou Hong , Liang Joshua G. , Liang Peng 
Published: July 2017

AbstractAberrant expression of TNF family of cytokines has been linked to human diseases, and biologics targeting their signaling have become the best selling drugs globally. However, functional detection with labeled ligands for accurate detection of TNFR family of receptor-expressing target tissues or cell types remains to be developed. Here we show that TNF receptor family members are heat-stable and can be recognized both in vitro and in vivo by their ligands labeled with alkaline phosphatase. Such an approach may be used in lieu of antibodies for the identification of the cell types involved in receptor signaling during disease onset and progression.
Molecular and Physical Mechanisms of Fibrinolysis and Thrombolysis from Mathematical Modeling and Experiments
Authors: Bannish Brittany E. , Chernysh Irina N. , Keener James P. , Fogelson Aaron L. , Weisel John W. 
Published: July 2017

AbstractDespite the common use of thrombolytic drugs, especially in stroke treatment, there are many conflicting studies on factors affecting fibrinolysis. Because of the complexity of the fibrinolytic system, mathematical models closely tied with experiments can be used to understand relationships within the system. When tPA is introduced at the clot or thrombus edge, lysis proceeds as a front. We developed a multiscale model of fibrinolysis that includes the main chemical reactions: the microscale model represents a single fiber cross-section; the macroscale model represents a three-dimensional fibrin clot. The model successfully simulates the spatial and temporal locations of all components and elucidates how lysis rates are determined by the interplay between the number of tPA molecules in the system and clot structure. We used the model to identify kinetic conditions necessary for fibrinolysis to proceed as a front. We found that plasmin regulates the local concentration of tPA through forced unbinding via degradation of fibrin and tPA release. The mechanism of action of tPA is affected by the number of molecules present with respect to fibrin fibers. The physical mechanism of plasmin action (crawling) and avoidance of inhibition is defined. Many of these new findings have significant implications for thrombolytic treatment.
UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization
Authors: Nakashima Ryota , Goto Yoko , Koyasu Sho , Kobayashi Minoru , Morinibu Akiyo , Yoshimura Michio , Hiraoka Masahiro , Hammond Ester M. , Harada Hiroshi 
Published: July 2017

AbstractHypoxia-inducible factor 1 (HIF-1) has been recognized as an important mediator of the reprogramming of carbohydrate metabolic pathways from oxidative phosphorylation to accelerated glycolysis. Although this reprogramming has been associated with the antioxidant and radioresistant properties of cancer cells, gene networks triggering the HIF-1-mediated reprogramming and molecular mechanisms linking the reprogramming with radioresistance remain to be determined. Here, we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1), which we previously identified as a novel HIF-1 activator, increased the radioresistance of cancer cells by producing an antioxidant, reduced glutathione (GSH), through HIF-1-mediated metabolic reprogramming. A luciferase assay to monitor HIF-1 activity demonstrated that the overexpression of UCHL1, but not its deubiquitination activity-deficient mutant (UCHL1 C90S), upregulated HIF-1 activity by stabilizing the regulatory subunit of HIF-1 (HIF-1α) in a murine breast cancer cell line, EMT6. UCHL1 overexpression induced the reprogramming of carbohydrate metabolism and increased NADPH levels in a pentose phosphate pathway (PPP)-dependent manner. The UCHL1-mediated reprogramming elevated intracellular GSH levels, and consequently induced a radioresistant phenotype in a HIF-1-dependent manner. The pharmacological inhibition of PPP canceled the UCHL1-mediated radioresistance. These results collectively suggest that cancer cells acquire antioxidant and radioresistant phenotypes through UCHL1-HIF-1-mediated metabolic reprogramming including the activation of PPP and provide a rational basis for targeting this gene network for radiosensitization.
Hearables: Multimodal physiological in-ear sensing
Authors: Goverdovsky Valentin , von Rosenberg Wilhelm , Nakamura Takashi , Looney David , Sharp David J. , Papavassiliou Christos , Morrell Mary J. , Mandic Danilo P. 
Published: July 2017

AbstractFuture health systems require the means to assess and track the neural and physiological function of a user over long periods of time, and in the community. Human body responses are manifested through multiple, interacting modalities – the mechanical, electrical and chemical; yet, current physiological monitors (e.g. actigraphy, heart rate) largely lack in cross-modal ability, are inconvenient and/or stigmatizing. We address these challenges through an inconspicuous earpiece, which benefits from the relatively stable position of the ear canal with respect to vital organs. Equipped with miniature multimodal sensors, it robustly measures the brain, cardiac and respiratory functions. Comprehensive experiments validate each modality within the proposed earpiece, while its potential in wearable health monitoring is illustrated through case studies spanning these three functions. We further demonstrate how combining data from multiple sensors within such an integrated wearable device improves both the accuracy of measurements and the ability to deal with artifacts in real-world scenarios.
Shift of EMT gradient in 3D spheroid MSCs for activation of mesenchymal niche function
Authors: Jeon Sohee , Lee Ho-Sun , Lee Ga-Young , Park Gyeongsin , Kim Tae-Min , Shin Jihye , Lee Cheolju , Oh Il-Hoan 
Published: July 2017

AbstractDespite the wide use of mesenchymal stromal cells (MSCs) for paracrine support in clinical trials, their variable and heterogeneous supporting activity pose major challenges. While three-dimensional (3D) MSC cultures are emerging as alternative approaches, key changes in cellular characteristics during 3D-spheroid formation remain unclear. Here, we show that MSCs in 3D spheroids undergo further progression towards the epithelial-mesenchymal transition (EMT), driven by upregulation of EMT-promoting microRNAs and suppression of EMT-inhibitory miRNAs. The shift of EMT in MSCs is associated with widespread histone modifications mimicking the epigenetic reprogramming towards enhanced chromatin dynamics and stem cell-like properties, but without changes in their surface phenotype. Notably, these molecular shifts towards EMT in 3D MSCs caused enhanced stem cell niche activity, resulting in higher stimulation of hematopoietic progenitor self-renewal and cancer stem cell metastasis. Moreover, miRNA-mediated induction of EMT in 2D MSCs were sufficient to mimic the enhanced niche activity of 3D spheroid MSCs. Thus, the molecular hierarchy in the EMT gradient among phenotypically indistinguishable MSCs revealed the previously unrecognized functional parameters in MSCs, and the EMT-enhanced “naïve” mesenchymal state represents an ‘activated mesenchymal niche’ in 3D spheroid MSCs.
TEPAPA: a novel in silico feature learning pipeline for mining prognostic and associative factors from text-based electronic medical records
Authors: Lin Frank Po-Yen , Pokorny Adrian , Teng Christina , Epstein Richard J. 
Published: July 2017

AbstractVast amounts of clinically relevant text-based variables lie undiscovered and unexploited in electronic medical records (EMR). To exploit this untapped resource, and thus facilitate the discovery of informative covariates from unstructured clinical narratives, we have built a novel computational pipeline termed Text-based Exploratory Pattern Analyser for Prognosticator and Associator discovery (TEPAPA). This pipeline combines semantic-free natural language processing (NLP), regular expression induction, and statistical association testing to identify conserved text patterns associated with outcome variables of clinical interest. When we applied TEPAPA to a cohort of head and neck squamous cell carcinoma patients, plausible concepts known to be correlated with human papilloma virus (HPV) status were identified from the EMR text, including site of primary disease, tumour stage, pathologic characteristics, and treatment modalities. Similarly, correlates of other variables (including gender, nodal status, recurrent disease, smoking and alcohol status) were also reliably recovered. Using highly-associated patterns as covariates, a patient’s HPV status was classifiable using a bootstrap analysis with a mean area under the ROC curve of 0.861, suggesting its predictive utility in supporting EMR-based phenotyping tasks. These data support using this integrative approach to efficiently identify disease-associated factors from unstructured EMR narratives, and thus to efficiently generate testable hypotheses.
Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis
Authors: Kuramoto Nobuo , Ohmura Koichiro , Ikari Katsunori , Yano Koichiro , Furu Moritoshi , Yamakawa Noriyuki , Hashimoto Motomu , Ito Hiromu , Fujii Takao , Murakami Kosaku , Nakashima Ran , Imura Yoshitaka , Yukawa Naoichiro , Yoshifuji Hajime , Taniguchi Atsuo , Momohara Shigeki , Yamanaka Hisashi , Matsuda Fumihiko , Mimori Tsuneyo , Terao Chikashi 
Published: July 2017

AbstractAnti-centromere antibody (ACA) is one of the classical anti-nuclear antibody (ANA) staining patterns. However, characteristics of ACA in comparison with the other ANA patterns and clinical features of ACA-positive subjects have not been elucidated. Here, we examined all ANA patterns by indirect immunofluorescence for 859 rheumatoid arthritis (RA) patients. Together with the ANA data of 9,575 healthy volunteers, we compared distributions of the ANA levels. ACA was the only ANA that demonstrated a definite bimodal distribution of levels. ACA showed significantly higher levels than the other ANA staining patterns in both RA and healthy population (p < 0.0001). ACA-positivity was associated with old age and was observed more in females. We further recruited another cohort of 3,353 RA patients and confirmed the findings. ACA was also associated with Raynaud’s phenomenon (p = 6.8 × 10−11) in RA. As a conclusion, ACA displays a specific ANA staining pattern with a bimodal distribution, and ACA-positive RA may constitute a distinct subset with specific clinical features.
A 4D view on the evolution of metamorphic dehydration reactions
Authors: Bedford John , Fusseis Florian , Leclère Henri , Wheeler John , Faulkner Daniel 
Published: July 2017

AbstractMetamorphic reactions influence the evolution of the Earth’s crust in a range of tectonic settings. For example hydrous mineral dehydration in a subducting slab can produce fluid overpressures which may trigger seismicity. During reaction the mechanisms of chemical transport, including water expulsion, will dictate the rate of transformation and hence the evolution of physical properties such as fluid pressure. Despite the importance of such processes, direct observation of mineral changes due to chemical transport during metamorphism has been previously impossible both in nature and in experiment. Using time-resolved (4D) synchrotron X-ray microtomography we have imaged a complete metamorphic reaction and show how chemical transport evolves during reaction. We analyse the dehydration of gypsum to form bassanite and H2O which, like most dehydration reactions, produces a solid volume reduction leading to the formation of pore space. This porosity surrounds new bassanite grains producing fluid-filled moats, across which transport of dissolved ions to the growing grains occurs via diffusion. As moats grow in width, diffusion and hence reaction rate slow down. Our results demonstrate how, with new insights into the chemical transport mechanisms, we can move towards a more fundamental understanding of the hydraulic and chemical evolution of natural dehydrating systems.