bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corneal Collagen Crosslinking for Corneal Ectasias: A Review
Authors: O’Brart David P.S. 
Published: December 2016

Purpose To review the published literature on corneal collagen crosslinking (CXL). Methods Importance has been placed on seminal publications, systemic reviews, meta-analyses, and randomized controlled clinical trials. Where such evidence was not available, cohort studies, case-controlled studies, and case series with follow-up greater than 12 months were examined. Results Corneal collagen crosslinking with riboflavin and ultraviolet A (UVA) 370 nm radiation appears to be capable of arresting the progression of ectatic corneal disorders, with most studies reporting significant improvements in visual, keratometric, and topographic measurements. Its mode of action at the molecular level is undetermined. Follow-up is limited to 5-10 years but suggests sustained stability and enhancement in corneal shape with time. Nearly all published long-term data and comparative studies are with epithelium-off techniques. Epithelium-on investigations suggest some efficacy but less than with epithelium-off treatments and long-term data are unavailable. Accelerated techniques with higher UVA fluencies and shorter treatments times, delivering the same UVA energy dosage, are the subject of recent investigation, with some laboratory and clinical studies suggesting reduced efficacy compared to the standard 3 mW/cm2 for 30 minutes irradiation procedure. Combined methodologies of CXL with techniques such as photorefractive keratectomy and intrastromal rings show promise but long-term follow-up is indicated. Sight-threatening complications of CXL are rare. Conclusions Studies of epithelium-off CXL with irradiation at 3 mW/cm2 for 30 minutes support its efficacy. Refinement in techniques may allow for safer and more rapid procedures with less patient discomfort but require further investigation.
Fulminant Idiopathic Intracranial Hypertension and Venous Stasis Retinopathy Resulting in Severe Bilateral Visual Impairment
Authors: Voldman Alexander , Durbin Breanna , Nguyen John , Ellis Brian , Leys Monique 
Published: December 2016

Purpose To report a complicated case of fulminant idiopathic intracranial hypertension and concomitant venous stasis retinopathy leading to postpapilledema optic atrophy. Methods Case report. Results A 34-year-old morbidly obese woman with a history of idiopathic intracranial hypertension (IIH) presented with a 1-month history of bilateral vision loss, diplopia, and left eye pain after being lost to follow-up for 6 years. Fundus examination revealed florid papilledema with venous tortuosity bilaterally. Brain and orbit magnetic resonance imaging showed bilateral globe flattening, intraocular optic nerve swelling in both eyes, and no abnormality on magnetic resonance venography. After additional workup including lumbar puncture with an opening pressure of 55 cm H2O, a diagnosis of IIH was confirmed. Medical treatment with oral carbonic anhydrase inhibitors was initiated, followed by same-day bilateral optic nerve sheath decompression and ventriculoperitoneal shunt placement the following week. Fundus examination 2 months later revealed a persistent blood and thunder fundus suggestive of bilateral central retinal vein occlusions. Over the course of 6 months, both eyes displayed postpapilledema optic atrophy with light perception and hand motion vision in the right and left eyes, respectively. On Goldmann perimetry, the patient had vague limited isolated responses in both eyes to the largest target. Conclusions Fulminant IIH can present with profoundly blinding complications recalcitrant to aggressive medical and surgical intervention. Central retinal vein occlusion is an uncommon blinding complication of IIH.
Dexamethasone Intravitreal Implant at the Time of Cataract Surgery in Eyes with Diabetic Macular Edema
Authors: Panozzo Giacomo A. , Gusson Elena , Panozzo Giorgio , Dalla Mura Giulia 
Published: December 2016

Purpose To determine the potential role of intraoperative dexamethasone intravitreal implant (DEX-I) in reducing diabetic macular edema (DME) worsening after phacoemulsification. Methods This was a prospective study on 19 eyes of 19 patients with type 2 diabetes mellitus with DME and cataract. Mean preoperative Early Treatment Diabetic Retinopathy Study visual acuity (VA) was 16.7 letters. Mean foveal thickness (FT) was 451 μm. The DME was naive in 11 eyes and refractory in 8 eyes. All eyes underwent a standard phacoemulsification and intraocular lens implantation; DEX-I was injected at the end of surgery. Follow-up was performed at 1 week and then monthly until DME recurrence (up to 8 months). Results At 1 week, mean VA improved by 15 letters (range 0-29 letters) and mean FT decreased by 147 μm (range 69-236 μm). Improvement consolidated at month 1, with a mean VA improvement of 18 letters (range 3-32 letters) and a mean improvement in FT of 193 μm (range 76-304 μm), remaining stable at month 2 after surgery in all eyes. The DME recurred in 1 eye at month 3, in 14 eyes (73.8%) between months 4 and 5, and after month 6 in 4 eyes (21%). Refractory DMEs demonstrated the same benefit but recurred earlier than naive ones (4 months versus 5.8 months, p<0.01). Conclusions Intraoperative DEX-I prevents DME worsening after phacoemulsification. Its positive effects last for at least 3 months.
Sleep Quality and Risk Factors of Atherosclerosis in Predialysis Chronic Kidney Disease
Authors: Guney Ibrahim , Akgul Yavuz S. S. , Gencer Vedat , Aydemir Harun , Asian Uysaler , Ecirli Samil 
Published: December 2016

Introduction Chronic kidney disease (CKD) patients have more frequent sleep disorders and cardiovascular disease than normals. Since arterial stiffness as a risk factor of atherosclerosis can be evaluated with pulse wave velocity (PWV), we aimed to investigate the prevalance of sleep quality (SQ) and the relationship between SQ and risk factors of atherosclerosis and whether there is a relationship between SQ and PWV (the indicator of arterial stiffness) in predialysis CKD patients. Methods This cross-sectional study was carried out in CKD patients followed at the Nephrology Department in Konya, Turkey, between November 2014 and March 2015. A total of 484 CKD patients were screened. Of the 484 patients, 285 patients were excluded. The remaining 199 CKD patients without cardiovascular disease at stage 3, 4, and 5 (predialysis) were included in the final study. The SQ of the patients was evaluated by the Pittsburgh Sleep Quality Index (PSQI). PWV was measured by using a single-cuff arteriography device (Mobil-O-Graph PWA, a model pulse wave analysis device; IEM). Results A total of 199 predialysis CKD patients were included in the study, 73 of whom (36.7%) were ‘poor sleepers’ (global PSQI >5). Patients with poor SQ were older than those with good SQ (p = 0.077). SQ was worse in female patients compered to male patients (p = 0.001). SQ was worse in obese patients. As laboratory parameters, serum phosphorus, LDL cholesterol, and triglycerides levels correlated positively with SQ (respectively; r = 0.245, p<0.001; r = 0.142, p = 0.049; r = 0.142, p = 0.048). The indicator of arterial stiffness, PWV, was higher in patients with poor SQ (p = 0.033). Hyperphosphatemia and female gender are determined as risk factors for poor SQ in multivariate analysis (p = 0.049, ExpB = 1.477; p = 0.009, ExpB = 0,429, respectively). Conclusions Our study showed for the first time that there is a relationship between SQ and risk factors of atherosclerosis in predialysis CKD patients.
Development of Polymeric Functionally Graded Scaffolds: A Brief Review
Authors: Scaffaro Roberto , Lopresti Francesco , Maio Andrea , Sutera Fiorenza , Botta Luigi 
Published: December 2016

Over recent years, there has been a growing interest in multilayer scaffolds fabrication approaches. In fact, functionally graded scaffolds (FGSs) provide biological and mechanical functions potentially similar to those of native tissues. Based on the final application of the scaffold, there are different properties (physical, mechanical, biochemical, etc.) which need to gradually change in space. Therefore, a number of different technologies have been investigated, and often combined, to customize each region of the scaffolds as much as possible, aiming at achieving the best regenerative performance. In general, FGSs can be categorized as bilayered or multilayered, depending on the number of layers in the whole structure. In other cases, scaffolds are characterized by a continuous gradient of 1 or more specific properties that cannot be related to the presence of clearly distinguished layers. Since each traditional approach presents peculiar advantages and disadvantages, FGSs are good candidates to overcome the limitations of current treatment options. In contrast to the reviews reported in the literature, which usually focus on the application of FGS, this brief review provides an overview of the most common strategies adopted to prepare FGS.
Up-Regulation of Long Noncoding RNA CCAL Predicts Poor Patient Prognosis and Promotes Tumor Metastasis in Osteosarcoma
Authors: Zhou Da-Kai , Yang Xi-Wang , Li Huining , Yang Yongbo , Zhu Zhen-Jun , Wu Na 
Published: December 2016

Background Long noncoding RNAs (IncRNAs) play essential roles in tumor progression. Aberrant colorectal cancer-associated IncRNA (CCAL) has been found in colorectal cancer. However, the function of IncRNA CCAL in osteosarcoma (OS) remains unclear. Methods Quantitative real-time PCR (qRT-PCR) was performed to measure CCAL expression in OS tissues and adjacent nontumor tissues. The correlation betweent CCAL expression and clinicopathological features and prognosis was also analyzed. In addition, the function of CCAL was further evaluated by cell proliferation, migration and invasion assays. Results We showed that CCAL was significantly up-regulated in OS tissues compared with adjacent nontumor tissues. Increased expression of CCAL was correlated with advanced TNM stage and metastasis. Kaplan-Meier analysis demonstrated that patients with high CCAL expression had lower overall survival than those with low CCAL expression. Multivariate Cox regression analysis indicated that CCAL expression might be an independent prognostic factor for OS patients. In addition, functional assays showed that decreased CCAL expression could inhibit OS cell proliferation, migration and invasion ability. Conclusions Our findings suggested that CCAL plays critical roles in OS progression and could act as a therapeutic target in the treatment of OS.
Increased Level of Annexin A1 in Bronchoalveolar Lavage Fluid as a Potential Diagnostic Indicator for Lung Cancer
Authors: Biaoxue Rong , Xiguang Cai , Hua Liu , Tian Fu , Wenlong Gao 
Published: December 2016

Background Annexin A1 has been implicated in various tumor types, but few studies have investigated its involvement in lung cancer. The purpose of this investigation was to quantify the annexin A1 level in bronchoalveolar lavage fluid (BALF) and analyze its usefulness in lung cancer diagnosis. Methods Annexin A1 expression was measured by immunohistochemistry and enzyme immunoassay. The sensitivity and specificity of annexin A1 for distinguishing lung cancer were determined by receiver operator characteristic (ROC) curves. Results Tumor tissues, BALF and serum of patients with lung cancer contained higher levels of annexin A1 than those of the control group of patients with benign lung diseases. Moreover, an increased level of BALF annexin A1 was closely correlated with lymphatic invasion and malignant progression of lung cancer. The sensitivity and specificity of BALF annexin A1 for distinguishing lung cancer were 94.2% and 90.2%, respectively. Conclusions Increased annexin A1 in BALF was correlated with lymphatic invasion and malignant progression of lung cancer, suggesting that it could be an indicator for discerning lung cancer and predicting outcome.
Genetic Polymorphisms of Vitamin D Receptor (VDR), CYP27B1 and CYP24A1 Genes and the Risk of Colorectal Cancer
Authors: Vidigal Verônica Marques , Silva Tiago Donizetti , de Oliveira Juliana , Pimenta Célia Aparecida Marques , Felipe Aledson Vitor , Forones Nora Manoukian 
Published: December 2016

Introduction Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC). The objective of this study was to investigate the relationship between the risk of CRC and polymorphisms in VDR, CYP27B1 and CYP24A1, lifestyle and dietary habits. Methods The study included 152 patients with CRC and 321 controls. All participants answered a questionnaire on their dietary habits, alcohol consumption and smoking habits. DNA was extracted from peripheral blood. Polymorphisms of BsmI and ApaI were identified by performing PCR-RFLP. Identification of CYP24A1 (rs6013897, rs158552 and rs17217119) and CYP27B1 (rs10877012) polymorphisms was performed by gene sequencing. Results Smoking, alcohol use, and low or no consumption of fruit, cereals and dairy products were associated with an increased risk of CRC. A heterozygous genotype Aa or an association genotype aa + Aa of the VDR ApaI polymorphism increased the risk of CRC. The VDR BsmI polymorphism was not significantly associated with the risk of CRC. Multivariate analysis showed that heterozygous and association genotype AT + AA of the rs6013897 polymorphism, genotype CT of the rs158552 polymorphism, association genotype CT + CC and genotypes AA and GG of the rs17217119 polymorphism of CYP24A1, and heterozygous genotype GT and association genotype GT + TT of the rs10877012 polymorphism in CYP27B1 were associated with a higher risk of CRC. Conclusions Dietary habits, lifestyle, and polymorphisms in VDR (ApaI), CYP24A1 (rs6013897, rs158552, rs17217119) and CYP27B1 (rs10877012) were associated with a higher risk of CRC.
Synchronous Pancreatic and Pulmonary Metastases from Solitary Fibrous Tumor of the Pleura: Report of a Case
Authors: Tamburini Nicola , Fabbri Nicolò , Anania Gabriele , Maniscalco Pio , Quarantotto Francesco , Rinaldi Rosa , Cavallesco Giorgio 
Published: December 2016

Introduction Solitary fibrous tumor of the pleura is an uncommon tumor with an indolent course and a good prognosis after surgical resection. However, the tumor occasionally follows an unpredictable clinical course and malignant transformation has been reported to increase the rate of local recurrence. Solitary extrathoracic metastasis from solitary fibrous tumor of the pleura is an uncommon finding. Case Presentation In this case report we present the first case of a synchronous single pulmonary and pancreatic metastasis treated with minimally invasive surgery. Conclusions Pancreatic recurrence should be considered in the postoperative follow-up in patients with solitary fibrous tumor of the pleura.
Multiple Chromophobe and Clear Cell Renal Cancer in A Patient Affected by Birt-Hogg-Dubè Syndrome: A Case Report
Authors: Castellucci Roberto , Marchioni Michele , Valenti Sergio , Sortino Giuseppe , Borgonovo Giulio , Pesenti Nicola , Vismara Alberto C.A. , Circo Maria C. , Sessa Barbara , Micheli Emanuele , Lembo Antonino 
Published: December 2016

Objectives Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant characterized by the presence of fibrofolliculomas and/or trichodiscomas, pulmonary cysts, spontaneous pneumothorax, and renal tumors. The syndrome is linked to mutations in the FLCN gene, which is preferentially expressed in the skin, kidney, and lung. The aim of our paper is to describe a case of multiple bilateral renal cancer in a patient affected by BHDS. Case Presentation Patient subjected to enucleoresection seven kidney tumors discovered right after ultrasound performed for other reasons. Definitive histologic examination were as follows: multifocal type chromophobe renal cell carcinoma and clear cell. After 1 month, the patient was readmitted for spontaneous pneumothorax. After about a year, the patient was again subjected to resection of multiple renal tumors left. Histological examination proved that it was multifocal renal cell carcinoma, clear cell varieties. The genome analysis highlighted positive for mutation c. 1379_1380 of FLCN gene, BHDS gene. Currently, the patient is under close follow-up. After 1 year, the chest computed tomography (CT) confirmed the presence of minute air bubbles scattered on both sides. Instead, the abdominal CT was positive for a small round lesion 6 mm exophytic. Conclusions The BHDS is a rare syndrome whose management is extremely complex both in terms of oncological and functional. Kidney tumors associated with BHDS usually have a favorable clinical course. Present evidence suggests a close follow-up of the carriers of the genetic mutation patients whether or not they have expressed the lesions of disease given the high rate of recurrence of renal lesions.
Análise das tendências temáticas de artigos publicados na Revista de Educação Especial: 2010 – 2013
Authors: Buzetti Miryan Cristina , Barbosa Regiane Da Silva , Costa Maria Da Piedade Resende da 
Published: December 2016

O objetivo do presente trabalho é verificar as tendências de pesquisa na Revista Educação Especial nos anos de 2010 a 2013 e identificar os temas de pesquisa mais desenvolvidos nos últimos anos; identificando também os temas pouco explorados ou ausentes nos últimos quatro anos. A escolha da revista se justifica por ser uma revista de ampla divulgação consolidada e que apresenta somente artigos sobre Educação Especial. Trata-se de uma pesquisa bibliográfica de caráter qualitativo e quantitativo. Os artigos analisados foram acessados pelo site da revista totalizando 134 artigos. As informações coletadas foram organizadas em quadros descrevendo os temas desenvolvidos e pontuando o número de artigos discorrendo sobre cada tema, também foi tabulada a instituição de origem e se o artigo apresentava participantes ou não e quem eram os participantes. Os resultados demonstram que as instituições que mais publicam na revista são a Universidade Federal de São Carlos e a Universidade Federal de Santa Maria, a maioria das pesquisas não apresentam participantes, seguida de artigos com intervenções realizadas com profissionais. Os temas mais publicados são Educação Especial e Inclusão Escolar, os menos publicados são prevenção e definição de deficiência. Notamos que algumas deficiências ainda são pouco estudadas ou não apresentam intervenções efetivas, como no caso do transtorno global do desenvolvimento, nota-se uma preocupação muito grande em trabalhar com o autista, mas, pouco ou quase nada é apresentado sobre as demais demandas que se enquadram dentro desse grupo. Outro exemplo é em relação aos artigos voltados ao tema da surdez, no qual podemos constatar apenas um dentre doze relacionados ao implante coclear.
De l’appropriation à la propriété : John Locke et la fécondité d’un malentendu devenu classique
Authors: Fabri Eric 
Published: December 2016

Le cinquième chapitre du Second traité du gouvernement de John Locke a été l’objet de nombreuses mésinterprétations dont l’origine est à chercher dans la volonté des commentateurs d’y trouver une « théorie de la propriété », là où ne se trouvait qu’une « théorie de l’appropriation ». Après une présentation du texte et de ses interprétations (Macpherson, Nozick, Tully et Spitz), l’article étudie le contexte d’écriture des Deux traités du gouvernement et la place qu’y occupe le cinquième chapitre pour démontrer que l’intention de Locke dans ce chapitre était restreinte : il ne s’agissait que de légitimer l’appropriation originelle dans l’état de nature en vue de poser les jalons indispensables à la démonstration aboutissant au droit de résistance. La distinction faite entre « théorie de la propriété » et « théorie de l’appropriation » permet alors de comprendre comment les interprètes ont extrapolé les écrits de Locke et quels problèmes cette extrapolation pose aux théories modernes de la propriété d’inspiration lockéenne (et en particulier à l’Entitlement Theory de Robert Nozick).
Esthétique et événement
Authors: Mees Martin 
Published: December 2016

Cet article propose une réévaluation de la notion d’« événement » en matière d’esthétique, ce qui nécessite de s’interroger plus spécifiquement sur la temporalité propre au concept de « sublime », associé traditionnellement à une fulgurance, un instant sidérant qui ferait justementévénement. Le développement s’appuie sur l’Analytiquekantienne du sublime qui, en diverses occasions, met en avant le caractère paradoxal d’un sublime qui ne semble pouvoir se déployer qu’au prix d’une temporalité double, qualifiée ultimement derégressive. Je défendrai ici la thèse que le sublime renvoie en réalité à une expérience esthétique de l’événement comme tel, à même de nous faire penser une certaine « Idée esthétique » du temps. Une telle expérience semble d’ailleurs pouvoir trouverformedans différentes productions poétiques de notre modernité.
Les élections sont-elles essentielles à la démocratie ?
Authors: Pourtois Hervé 
Published: December 2016

En dépit de débats nourris sur la délibération et la représentation démocratiques, la question de la justification de l’élection comme mode de désignation des gouvernants a été peu abordée par la philosophie politique contemporaine. Cette question est pourtant importante. Une confrontation avec l’alternative que pourrait constituer le tirage au sort d’une assemblée représentative permet d’identifier les vertus spécifiques de l’élection au regard de quatre critères de légitimité démocratique : le consentement et la responsabilité des gouvernés, l’inclusion égalitaire des citoyens, le contrôle des décideurs et la contestabilité des décisions, la qualité épistémique de la décision. L’analyse conduit à conclure au caractère essentiel de l’élection dans des démocraties de masse. C’est à partir d’elle, et non en dépit d’elle, que doit être surmontée la crise de la représentation.
Visages de la paternité au Québec, 1900-19601
Authors: Gossage Peter 
Published: December 2016

L’auteur poursuit une réflexion historique sur les pères et la paternité au Québec entre 1900 et 1960, inspirée par l’historiographie internationale dans ce domaine et alimentée par quatre corpus des sources distincts et complémentaires. S’inscrivant dans le cadre de cette réflexion et de cette recherche plus larges, son propos ici vise dans un premier temps à offrir une esquisse rapide d’un schéma en trois « modèles » successifs – le père pourvoyeur, le père éducateur et le nouveau père – qui structurent, selon sa lecture, l’historiographie des pères au Québec depuis le XIXe siècle. Par la suite, il propose le concept des « visages de la paternité » comme nouvelle grille d’analyse, empruntée aux historiens John Demos et Robert Rutherdale, qui favorise une interprétation plus riche, plus nuancée et moins linéaire de cette histoire. Au final, l’auteur puise dans deux corpus de sources, à savoir les récits de vie et les annonces publicitaires, pour démontrer à partir de quatre exemples (le père spirituel, le père disciplinaire, le père prévoyant et le père sportif) à quel point ce concept des visages permet de faire avancer la discussion. C’est dire en même temps qu’il est nécessaire et très possible de situer les pères québécois par rapport à une gamme de rôles, d’attentes et de responsabilités dynamique dans le temps, variable dans l’espace social ou géographique et beaucoup plus vaste et complexe que généralement reconnue.