bluuebunny/crossref_metadata_2025_split huggingface dataset:
Money Following Trust: Evidence from China’s High‐Value Payment System
Authors: Qian Xianhang , Zhang Guangli , Cao Tingqiu 
Published: January 2018

AbstractThis study enriches the economic consequence of trust from the perspective of cash flow. It analyzes the impact of trust on interprovincial cash flow using matching data pertaining to Chinese provincial trust and the high‐value payment system in 2006–2010. It further investigates trust’s effect in different legal protection scenarios to explore the interactive role of formal and informal institutions. The results indicate that trust can significantly promote interprovincial cash flow and it persists after addressing endogeneity concerns and across different methods. However, this effect is only significant or much larger in provinces with less legal protection, indicating the alternative roles played by trust and formal institutions.
Brief report: Exploring the benefits of a peer‐tutored physical education programme among high school students with intellectual disability
Authors: Gobbi Erica , Greguol Márcia , Carraro Attilio 
Published: January 2018

BackgroundThe purpose of this study was to explore possible benefits of a peer‐tutored physical education programme (PTPE) in comparison with school physical education (SPE) in high school students with intellectual disability.MethodNineteen students with intellectual disabilities (15 boys, mean age 17.4 ± 1.7 years) were monitored during three PTPE and three SPE classes. A factorial RM‐ANOVA was used to test differences on objective measured physical activity (PA), enjoyment and exertion during the two conditions, considering participants’ weight condition as independent factor.ResultsDuring PTPE, participants reported higher light intensity PA, enjoyment and exertion than during SPE. Participants with overweight showed less inactive time and higher light intensity PA during PTPE than during SPE.ConclusionsThe peer‐tutored programme was beneficial for adolescents with intellectual disability, particularly for those in overweight condition. The higher enjoyment found during PTPE may encourage exercise participation of students with intellectual disability.
Maternal sensitivity to distress, attachment and the development of callous‐unemotional traits in young children
Authors: Wright Nicola , Hill Jonathan , Sharp Helen , Pickles Andrew 
Published: January 2018

BackgroundCallous‐unemotional (CU) traits are characterized by a lack of responsiveness to the emotions of others, particularly negative emotions. A parenting environment where the child's own distress emotions are sensitively responded to may help foster the child's ability to respond to the emotions of others. We tested whether maternal sensitivity to distress, and other parenting characteristics, were associated with CU traits over the preschool period, and examined whether this was mediated via infant attachment status.MethodIn an epidemiological cohort, CU traits were assessed at age 2.5, 3.5, and 5.0 years by mother report. Dimensions of parenting were assessed in free play at age 29 weeks in a stratified subsample of 272, and attachment status at 14 months (n = 265). Structural equation modelling with maximum likelihood estimation was used to examine predictions from parenting dimensions and attachment status.ResultsA parenting factor comprised of sensitivity to distress (n = 207), sensitivity to non‐distress, positive regard toward the infant (or warmth), and intrusiveness, predicted child CU traits (p = .023). This effect was accounted for mainly by sensitivity to distress (p = .008) and positive regard (p = .023) which showed a synergistic effect as evidenced by a significant interaction (p = .01). This arose because the combination of low sensitivity to distress and low positive regard created the risk for elevated CU traits. Although sensitivity and positive regard predicted attachment security and disorganization, there were no associations between attachment status and CU traits.ConclusionsThe finding of contributions from both sensitivity to distress and positive regard to reduced CU traits suggests that children's responsiveness to others’ emotions may be increased by their own mothers’ responsiveness to them and their mothers’ warmth. There was no evidence that this was mediated via attachment status. Implications for intervention and future directions are discussed.
Corneal confocal microscopy detects severe small fiber neuropathy in diabetic patients with Charcot neuroarthropathy
Authors: Khan Adnan , Petropoulos Ioannis N , Ponirakis Georgios , Menzies Robert A , Chidiac Omar , Pasquier Jennifer , Abi Khalil Charbel , Talal Talal K , Malik Rayaz A 
Published: January 2018

AbstractAims/IntroductionThe aim of the present study was to identify the extent of small fiber neuropathy in diabetic patients with Charcot neuroarthropathy (CN).Materials and MethodsA total of 20 patients with CN were compared with 20 age‐ and diabetes duration‐matched patients with type 2 diabetes and 20 age‐matched control participants. All patients underwent corneal confocal microscopy with quantification of corneal nerve morphology and assessment for vibration perception threshold, and a subset of patients with CN underwent assessment of sudomotor function and neuropathic pain.ResultsIn patients with CN compared with type 2 diabetes patients and control participants, there was a significant reduction in corneal nerve fiber density (14.94 ± 8.23 vs 23.86 ± 7.71, P = 0.004 vs 34.84 ± 9.13, P < 0.001), corneal nerve branch density (18.61 ± 16.7 vs 41.62 ± 22.67, P = 0.032 vs 76.47 ± 38.44, P < 0.001) and corneal nerve fiber length (8.40 ± 4.83 vs 14.87 ± 4.76, P = 0.001 vs 21.24 ± 6.48, P < 0.001), electrochemical skin conductance on the feet (20.57 ± 13.99 vs 61.50 ± 22.26, P < 0.001 vs 76.23 ± 12.01, P < 0.001) and hands (30.86 ± 18.10 vs 61.13 ± 19.14, P = 0.001 vs 68.31 ± 11.96, P < 0.001), and a significant increase in the vibration perception threshold in the feet (38.46 ± 15.10 vs 14.15 ± 10.25, P < 0.001 vs 7.75 ± 4.01, P < 0.001).ConclusionsPatients with diabetes and CN have severe large and particularly small fiber neuropathy.
Development and validation of risk models to predict the 7‐year risk of type 2 diabetes: The Japan Epidemiology Collaboration on Occupational Health Study
Authors: Hu Huanhuan , Nakagawa Tohru , Yamamoto Shuichiro , Honda Toru , Okazaki Hiroko , Uehara Akihiko , Yamamoto Makoto , Miyamoto Toshiaki , Kochi Takeshi , Eguchi Masafumi , Murakami Taizo , Shimizu Makiko , Tomita Kentaro , Nagahama Satsue , Imai Teppei , Nishihara Akiko , Sasaki Naoko , Ogasawara Takayuki , Hori Ai , Nanri Akiko , Akter Shamima , Kuwahara Keisuke , Kashino Ikuko , Kabe Isamu , Mizoue Tetsuya , Sone Tomofumi , Dohi Seitaro ,   the Japan Epidemiology Collaboration on Occupational Health Study Group
Published: January 2018

AbstractAims/IntroductionWe previously developed a 3‐year diabetes risk score in the working population. The objective of the present study was to develop and validate flexible risk models that can predict the risk of diabetes for any arbitrary time‐point during 7 years.Materials and MethodsThe participants were 46,198 Japanese employees aged 30–59 years, without diabetes at baseline and with a maximum follow‐up period of 8 years. Incident diabetes was defined according to the American Diabetes Association criteria. With routine health checkup data (age, sex, abdominal obesity, body mass index, smoking status, hypertension status, dyslipidemia, glycated hemoglobin and fasting plasma glucose), we developed non‐invasive and invasive risk models based on the Cox proportional hazards regression model among a random two‐thirds of the participants, and used another one‐third for validation.ResultsThe range of the area under the receiver operating characteristic curve increased from 0.73 (95% confidence interval 0.72–0.74) for the non‐invasive prediction model to 0.89 (95% confidence interval 0.89–0.90) for the invasive prediction model containing dyslipidemia, glycated hemoglobin and fasting plasma glucose. The invasive models showed improved integrated discrimination and reclassification performance, as compared with the non‐invasive model. Calibration appeared good between the predicted and observed risks. These models performed well in the validation cohort.ConclusionsThe present non‐invasive and invasive models for the prediction of diabetes risk up to 7 years showed fair and excellent performance, respectively. The invasive models can be used to identify high‐risk individuals, who would benefit greatly from lifestyle modification for the prevention or delay of diabetes.
Thinking about complexity in health: A systematic review of the key systems thinking and complexity ideas in health
Authors: Rusoja Evan , Haynie Deson , Sievers Jessica , Mustafee Navonil , Nelson Fred , Reynolds Martin , Sarriot Eric , Swanson Robert Chad , Williams Bob 
Published: January 2018

AbstractRationale, aims, and objectivesAs the Sustainable Development Goals are rolled out worldwide, development leaders will be looking to the experiences of the past to improve implementation in the future. Systems thinking and complexity science (ST/CS) propose that health and the health system are composed of dynamic actors constantly evolving in response to each other and their context. While offering practical guidance for steering the next development agenda, there is no consensus as to how these important ideas are discussed in relation to health. This systematic review sought to identify and describe some of the key terms, concepts, and methods in recent ST/CS literature.MethodUsing the search terms “systems thinkin * AND health OR complexity theor* AND health OR complex adaptive system* AND health,” we identified 516 relevant full texts out of 3982 titles across the search period (2002‐2015).ResultsThe peak number of articles were published in 2014 (83) with journals specifically focused on medicine/healthcare (265) and particularly the Journal of Evaluation in Clinical Practice (37) representing the largest number by volume. Dynamic/dynamical systems (n = 332), emergence (n = 294), complex adaptive system(s) (n = 270), and interdependent/interconnected (n = 263) were the most common terms with systems dynamic modelling (58) and agent‐based modelling (43) as the most common methods.ConclusionsThe review offered several important conclusions. First, while there was no core ST/CS “canon,” certain terms appeared frequently across the reviewed texts. Second, even as these ideas are gaining traction in academic and practitioner communities, most are concentrated in a few journals. Finally, articles on ST/CS remain largely theoretical illustrating the need for further study and practical application. Given the challenge posed by the next phase of development, gaining a better understanding of ST/CS ideas and their use may lead to improvements in the implementation and practice of the Sustainable Development Goals.
Evaluation of enumeration and MPN prediction methods for Staphylococcus aureus
Authors: Hait Jennifer , Tallent Sandra , Ferguson Martine 
Published: January 2018

AbstractStaphylococcal food poisoning is among the most prevalent causes of foodborne intoxication. To monitor the safety and quality of food, rapid and reliable enumeration procedures for Staphylococcus aureus are essential. Here, we assess culture‐based methods for the isolation and enumeration of S. aureus, testing different pre‐enrichment broths, plated media, and the automated TEMPO instrument. We evaluated enumeration of S. aureus in seven different food commodities, including two naturally contaminated foods, at levels ranging between 100 and 1,500 cfu/g of inoculated target and nontarget organisms. Sixty‐four food samples were analyzed. Duplicate test portions of 25 g each were homogenized with 225 ml of Butterfield's phosphate buffer (1:10). Five tube most probable number (MPN) predictions comparing two pre‐enrichment broths, tryptic soy broth containing 10% NaCl and 1% sodium pyruvate (PTSBS) and modified Giolitti and Cantoni (GC) were assessed alongside the TEMPO STA card and the direct plate count method. The direct plate count method using Baird Parker agar and BP with Rabbit Plasma Fibrinogen versus TEMPO STA demonstrated the highest proportion of agreement at 89.19%. The two different pre‐enrichment broths assessed, PTSBS versus GC exhibited the lowest proportion of agreement at 47.5%. The TEMPO STA yielded results in 24 hr versus the current 4‐day PTSBS MPN method for S. aureus, with an 84.62% agreement.Practical applicationsOverall food quality, recalls, and other regulatory decisions are often contingent upon enumeration results. A prompt turnaround time can assist in expediting the release of unadulterated foods, and the swift removal of adulterated foods out of the food supply chain. This is paramount to the microbiology and food safety community who must consider which methods will provide more accurate and timely assessments of food contamination.
Sofosbuvir plus ribavirin with or without peginterferon for the treatment of hepatitis C virus: Results from a phase 3b study in China
Authors: Wei Lai , Xie Qing , Hou Jin Lin , Jia Jidong , Li Wu , Xu Min , Li Jun , Wu Shanming , Cheng Jun , Jiang Jianning , Wang Guiqiang , Yang Yongfeng , Mou Zhuangbo , Gao Zhi Liang , Gong Guozhong , Niu Jun Qi , Hu Peng , Tang Hong , Lin Feng , Dou Xiaoguang , Li Lanjuan , Zhang Lun Li , Nan Yuemin , Massetto Benedetta , Yang Jenny C , Knox Steven J , Kersey Kathryn , German Polina , Mo Hongmei , Jiang Deyuan , Brainard Diana M , Jiang Jiaji , Ning Qin , Duan Zhongping 
Published: January 2018

AbstractBackground and AimSofosbuvir is a nucleotide analog inhibitor of the hepatitis C virus (HCV) NS5B RNA polymerase with pangenotypic potency. This phase 3b study evaluated the safety and efficacy of sofosbuvir + ribavirin ± peginterferon in Chinese patients infected with HCV genotype 1, 2, 3, or 6.MethodsPatients with genotype 1 or 6 received sofosbuvir + peginterferon/ribavirin for 12 weeks or sofosbuvir + ribavirin for 24 weeks, depending on prior treatment and interferon eligibility. Patients with genotype 2 or 3 received sofosbuvir + ribavirin for 12 or 24 weeks, respectively. The primary endpoint was sustained virologic response at 12 weeks after the end of treatment (SVR12).ResultsOf 389 patients, 42% had genotype 1, 16% genotype 2, 32% genotype 3, and 9% genotype 6. Half were male, 58% were treatment‐naïve, and 15% had cirrhosis. SVR12 rates for patients receiving 12 weeks of sofosbuvir + peginterferon/ribavirin were 94% (95% confidence interval [CI], 87–98%) for HCV genotype 1 and 97% (95% CI, 84–100%) for genotype 6. SVR12 rates for those receiving sofosbuvir + ribavirin for 24 weeks were 95% (95% CI, 87–99%) for genotype 1, 100% (95% CI, 40–100%) for genotype 6, and 95% (95% CI, 90–98%) for genotype 3. For genotype 2 patients receiving sofosbuvir + ribavirin for 12 weeks, the SVR12 rate was 92% (95% CI, 83–97%). Twenty patients (5%) relapsed. Ten (3%) experienced serious adverse events. Three (< 1%) discontinued treatment because of adverse events, of whom one died because of treatment‐unrelated adverse events.ConclusionsSofosbuvir‐based regimens were highly effective and safe in Chinese patients with HCV genotype 1, 2, 3, or 6, suggesting sofosbuvir could serve as the backbone for HCV treatment in China irrespective of genotype.
Non‐invasive assessments for liver fibrosis: The crystal ball we long for
Authors: Wong Grace Lai‐Hung 
Published: January 2018

AbstractNon‐invasive assessment of liver fibrosis has been one of the most rapidly advancing fields in hepatology in the last decade. Progressive liver fibrosis results in cirrhosis, hepatocellular carcinoma (HCC), and various liver‐related complications in essentially all chronic liver diseases. Assessment of liver fibrosis allows clinicians to determine the prognosis, need of treatment, disease progression, and response to treatment in patients with chronic liver disease. Liver biopsy has been the gold standard in last few decades and most adopted diagnostic tool in clinical trials. Nonetheless, it is impractical to apply the test in a large number of patients or to do it serially. Hence, various non‐invasive assessments have been developed and adopted in some international management guidelines. Liver stiffness measurement (LSM) with transient elastography is one of the most widely validated non‐invasive assessments for liver fibrosis. It is an accurate and reproducible method to predict advanced fibrosis in chronic hepatitis B. Using transient elastography, it is possible to perform repeated liver fibrosis assessments on a large number of asymptomatic patients. The key challenge of his tool is the confounding effect of alanine aminotransferase (ALT) level, such that decrease in LSM may only reflect ALT normalization, hence not accurate enough to indicate regression of liver fibrosis. This may be partially handled by combining LSM with a serum‐based formula, which is independent of ALT such as the Forns index and enhanced liver fibrosis test. An LSM‐based HCC risk score is useful to prioritize patients for HCC surveillance.
Life Cycle Assessment of Aerogel Manufacture on Small and Large Scales: Weighing the Use of Advanced Materials in Oil Spill Remediation
Authors: Karatum Osman , Bhuiya Md Mainul H. , Carroll Mary K. , Anderson Ann M. , Plata Desiree L. 
Published: January 2018

SummaryRecent studies demonstrated that advanced aerogel composites (Aspen Aerogels® Spaceloft® [SL]) have the potential to transform oil remediation via high oil uptake capacity and selectivity, excellent reusability, and high mechanical strength. Understanding the life cycle environmental impacts of advanced aerogels can enable a more holistic decision‐making process when considering oil recovery technologies following a spill. Here, we perform a cradle‐to‐grave streamlined life cycle assessment (LCA) following International Organization for Standardization (ISO) 14040 2006 for SL weighed against the conventional oil sorbent material, polyurethane foam. The model included alternative use and disposal scenarios, such as single or multiple uses, and landfill, incinerator, and waste‐to‐energy (WTE) approaches for cleaning 1 cubic meter (m3) of light crude oil. Results showed that the ideal case for SL application was comprised of multiple use and WTE incineration (68% reduction in material use, approximately 7 × 103 megajoules [MJ] of energy recovery from WTE), but SL offered energy and materials savings even when used once and disposed of via traditional means (i.e., landfill). In addition to evaluating these already‐scaled processes, we performed an anticipatory LCA for the laboratory‐scaled aerogel fabrication process that might inform the sustainable design of next‐generation aerogels. In particular, the model compared rapid supercritical extraction (RSCE) with two conventional supercritical extraction methods—alcohol and carbon dioxide supercritical extraction (ASCE and CSCE, respectively)—for silica aerogel monoliths. Our results showed that RSCE yielded a cumulative energy savings of more than 76 × 103 and 100 × 103 MJ for 1 m3 of monolithic silica aerogel manufacturing compared to ASCE and CSCE, respectively.
Molecular genetic identification of isolates of the hepatitis A virus (HAV) from monkeys at Adler Primate Center
Authors: Dogadov Dmitriy I. , Korzaya Lydia I. , Karlsen Anastasia A. , Kyuregyan Karen K. 
Published: January 2018

AbstractBackgroundThe aim of this study was to assess prevalence and genetic variability of hepatitis A virus (HAV) isolates in monkeys born and kept at Adler Primate Center, as well as in imported animals.MethodsThe fecal samples from various species of monkeys (n = 119) were studied using reverse transcription seminested PCR, sequencing, and phylogenetic analysis.ResultsHAV RNA was detected in 2 Macaca mulatta and 1 Macaca fascicularis (3.8%) kept at Adler Primate Center (n = 79) and in 11 (27.5%) Chlorocebus pygerythrus (n = 40) imported from Tanzania. Phylogenetic analysis demonstrated that all HAV strains belonged to simian genotype V, but differed from the prototype genotype V strain (AGM‐27) by 5.4%‐5.5%. Sequences isolated in this study differed by only 0.1%, suggesting a common source of infection.ConclusionsThis study demonstrated the asymptomatic circulation of HAV genotype V among the monkeys at Adler Primate Center, and it indicated the significant genetic diversity within this HAV genotype.
Clinical and genetic features of Charcot‐Marie‐Tooth disease 2F and hereditary motor neuropathy 2B in Japan
Authors: Tanabe Hajime , Higuchi Yujiro , Yuan Jun‐Hui , Hashiguchi Akihiro , Yoshimura Akiko , Ishihara Satoshi , Nozuma Satoshi , Okamoto Yuji , Matsuura Eiji , Ishiura Hiroyuki , Mitsui Jun , Takashima Ryotaro , Kokubun Norito , Maeda Kengo , Asano Yuri , Sunami Yoko , Kono Yu , Ishigaki Yasunori , Yanamoto Shosaburo , Fukae Jiro , Kida Hiroshi , Morita Mitsuya , Tsuji Shoji , Takashima Hiroshi 
Published: January 2018

AbstractMutations in small heat shock protein beta‐1 (HspB1) have been linked to Charcot‐Marie‐Tooth (CMT) disease type 2F and distal hereditary motor neuropathy type 2B. Only four cases with HSPB1 mutations have been reported to date in Japan. In this study between April 2007 and October 2014, we conducted gene panel sequencing in a case series of 1,030 patients with inherited peripheral neuropathies (IPNs) using DNA microarray, targeted resequencing, and whole‐exome sequencing. We identified HSPB1 variants in 1.3% (13 of 1,030) of the patients with IPNs, who exhibited a male predominance. Based on neurological and electrophysiological findings, seven patients were diagnosed with CMT disease type 2F, whereas the remaining six patients were diagnosed with distal hereditary motor neuropathy type 2B. P39L, R127W, S135C, R140G, K141Q, T151I, and P182A mutations identified in 12 patients were described previously, whereas a novel K123* variant with unknown significance was found in 1 patient. Diabetes and impaired glucose tolerance were detected in 6 of the 13 patients. Our findings suggest that HSPB1 mutations result in two phenotypes of inherited neuropathies and extend the phenotypic spectrum of HSPB1‐related disorders.
The 100 most cited articles on oral cancer
Authors: Pena‐Cristóbal Maite , Diniz‐Freitas Márcio , Monteiro Luis , Diz Dios Pedro , Warnakulasuriya Saman 
Published: January 2018

BackgroundCitations analysis is one of the most widely used bibliometric tools to evaluate the academic importance of a study in a specific area of knowledge. The objective of this study was to identify the 100 most cited articles on oral cancer and to analyse their principal characteristics.MethodsWe performed a literature search in the Web of Science database using the Science Citation Index Expanded tool to determine the number of citations of all articles on oral cancer identified up to 10 August 2017. The 100 most referenced articles were then selected, and the following information was gathered: ranking based on the number of citations; citation density; citations in Scopus; number and names of the authors; language and year of publication; country and institution of origin; financial support; journal of publication, with its impact factor, category and quartile; type of research; evidence level; and area of study.ResultsThe number of citations of the 100 articles varied from 1959 to 165, and the number of authors varied from a single author to 23. The oldest article was from 1948, and the most recent was from 2013. All the studies were published in English, the majority (56%) was from the United States, and 80% were published in journals in the first quartile.ConclusionsThe majority of articles were of studies that had received financial support, were published in journals with a high impact factor and were focussed on the aetiology and pathogenesis of oral cancer.