bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Preterm Birth in Pakistan: A Systematic Review and Meta-Analysis
Authors: Hanif Asif , Ashraf Tahira , Waheed Khadija , Sajid Mirza Rizwan , Güler Nesrin , Pervaiz Muhammad Khalid 
Published: August 2017

<p><strong>Objective: </strong>This study is designed to systematically review the prevalence of preterm birth from previously published studies of Pakistan and to find pooled prevalence from available local data.</p><p><strong>Methodology:</strong><strong> </strong>Targeted literature was searched with specific key words such as “preterm birth, prematurity, prevalence and mortality in preterm birth in Pakistan”. Studies with copyright and/or permission issues were excluded. A total of 300 studies were found initially that were somewhat related to the topic, after careful screening only 5 studies met inclusion criteria for current study. To test the null hypothesis for all studies evaluating effect Cochran's <em>Q</em> was used and P-values with a level of significance of 5%were considered significant.</p><p><strong>Results:</strong><strong> </strong>The pooled prevalence of Preterm Birth was found to be 18.89% using fixed effect, 16.81% using random effect and 18.89% using fixed effect heterogeneity. I-squared for each effect model was &gt; 75%. On applying Chi<sup>2</sup> test we obtained significant p-value i.e. p-value &lt; 0.01.</p><p><strong>Conclusion:</strong><strong> </strong>Through this meta-analysis we found one of the highest pooled prevalence of preterm birth in Pakistan. Reducing preterm birth can result in improvement of overall neonatal health and significantly reduce neonatal mortality in future.</p>
Effect of Company during Academic Years on Habit of Cigarette Smoking among Doctors
Authors: Mustafa Awais , Jawad Shahbano , Khosa Shahid Hameed , Zafar Humaira 
Published: August 2017

<p><strong>Objective:</strong><strong> </strong>To assess the effect of company during academic years on the habit of cigarette smoking.<em></em></p><p><strong>Materials and Methods:</strong><strong> </strong>This Cross-sectional descriptive study was conducted in 130 doctors from three different hospitals of Lahore. Written consent was taken; participants were questioned about smoking habit. Data was analyzed using SPSS20.</p><p><strong>Result:</strong><strong> </strong>Doctors (all smokers) were questioned about smoking habits. Response rate was 100%. The greatest percentage of Doctors started smoking due to influence of friends and family (65%). Majority of them stayed in private hostels (58%) and flats (29%) during their academic years. These doctors showed greater tendency towards smoking than the doctors that stayed with their family/children (15%).</p><p><strong>Conclusion:</strong><strong> </strong>Our results showed a marked tendency of tobacco smoking in doctors living without their families/children in Lahore. Majorities have the smokers in their friend’s circle and had started smoking under influence of them. Doctors who lived in private flats/ hostels showed increase in tobacco use than who lived in the houses.</p>
Adoptive Immunotherapy for B-cell Malignancies Using CD19- Targeted Chimeric Antigen Receptor T-Cells: A Systematic Review of Efficacy and Safety
Authors: Hao Lu , Li Tongtong , Chang Lung-Ji , Chen Xiaochuan 
Published: August 2017

Background:Adoptive infusion of chimeric antigen receptor transduced T- cells (CAR-T) is a powerful tool of immunotherapy for hematological malignancies, as evidenced by recently published and unpublished clinical results.Objective:In this report, we performed a meta-analysis to evaluate the efficacy and side effects of CAR-T on refractory and/or relapsed B-cell malignancies, including leukemia and lymphoma.Methods:Clinical studies investigating efficacy and safety of CAR-T in acute and chronic lymphocytic leukemia and lymphoma were identified by searching PubMed and EMBASE. Outcomes of efficacy subjected to analysis were the rates of complete remission (CR) and partial remission (PR). The safety parameters were the prevalence of adverse effects including fever, hypotension, and acute renal failure. Meta analyses were performed using R software. Weighted hazard ratio (HR) with 95% confidence intervals was calculated for each outcome. Fixed or random-effects models were employed depending on the heterogeneity across the included studies.Results:Nineteen published clinical studies with a total of 391 patients were included for the meta-analysis. The pooled rate of complete remission was 55% (95% CI 41%-69%); the pooled rate of partial remission was 25% (95% CI: 19%-33%). The prevalence of fever was 62% (95% CI: 41%-79%), the hypotension was 22% (95% CI: 15%-31%), and the acute renal failure was 24% (95% CI: 16%-34%). All adverse effects were manageable and no death was reported due to toxicity.Conclusion:CD19-targeted CAR-T is an effective modality in treating refractory B-cell malignancies including leukemia and lymphoma. However, there is still a need to develop strategies to improve the safety in its clinical use.
Targeting Protective Catalase of Tumor Cells with Cold Atmospheric Plasma- Activated Medium (PAM)
Authors: Bauer Georg 
Published: August 2017

Background:
Application of cold atmospheric plasma to medium generates “plasma-activated
medium” that induces apoptosis selectively in tumor cells and that has an antitumor effect in vivo. The underlying
mechanisms are not well understood.

Objective:
Elucidation of potential chemical interactions within plasma-activated medium and of reactions of
medium components with specific target structures of tumor cells should allow to define the active principle in
plasma activated medium.

Methods:
Established knowledge of intercellular apoptosis-inducing reactive oxygen/nitrogen species-dependent
signaling and its control by membrane-associated catalase and SOD was reviewed. Model experiments using
extracellular singlet oxygen were analyzed with respect to catalase inactivation and their relevance for the
antitumor action of cold atmospheric plasma. Potential interactions of this tumor cell-specific control system
with components of plasma-activated medium or its reaction products were discussed within the scope of the
reviewed signaling principles.

Results:
None of the long-lived species found in plasma-activated medium, such as nitrite and H2O2, nor OCl- or
.NO seemed to have the potential to interfere with catalase-dependent control of apoptosis-inducing signaling of
tumor cells when acting alone. However, the combination of H2O2 and nitrite might generate peroxynitrite. The
protonation of peroxnitrite to peroxynitrous acid allows for the generation of hydroxyl radicals that react with
H2O2, leading to the formation of hydroperoxide radicals. These allow for singlet oxygen generation and inactivation
of membrane-associated catalase through an autoamplificatory mechanism, followed by intercellular
apoptosis-inducing signaling.

Conclusion:
Nitrite and H2O2 in plasma-activated medium establish singlet oxygen-dependent interference
selectively with the control system of tumor cells.
Synergistic Antitumor Effect of Genitinib (Iressa®) with Flavonoids from the Scutellaria baicalensis Root on the Non-Small Cell Lung Cells
Authors: Hirata Y. , Tatsu M. , Amano C. , Kawaratani Y. , Hirata M. , Ohmomo Y. , Nagaoka Y. , Shibano M. , Sasaki T. , Uesato S. , Taniguchi M. 
Published: August 2017

Background:
As was reported, gefitinib (Iressa®) showed a strong growth inhibitory effect on non-small-cell lung cancer PC-9 cells with mutant EGFR, but did not so much on A549 cells with wild-type EGFR.

Observation:
We here demonstrated by isobolograms and combination index analyses that the paired combinations of gefitinib with flavonoids from Wogon (Scutellaria baicalensis root): wogonin, oroxylin A and chrysin exerted synergistic anti-tumor effects against A549 cells.

Result:
The cell cycle analyses revealed that the combination of gefitinib and oroxylin A in A549 cells induced more apoptotic cells than other paired combinations as well as gefitinib alone. Thus, it is anticipated that oroxylin A could help to enhance the remission rate in the gefitinib therapy for the patients with non-small cell cancer cells with wild-type EGFR which provide a poor prognosis.

Conclusion:
Since the Wogon flavonoids, wogonin, oroxylin A and chrysin, accelerated the acetylation of Lysine residues of histone proteins, it is suggested that they put forth anti-tumor activities through inhibition of histone deacetylases which mediated the post-translational modification of histones.
Utilizing Soft Computing for Determining Protein Deficiency
Authors: Hartati Sri , Nurdiati Sri 
Published: August 2017

Abstract— In recent years, the occurrence of protein shortage of children under 5 years old in many poor area has dramatically increased. Since this situation can cause serious problem to children like a delay in their growth, delay in their development and also disfigurement, disability, dependency, the early diagnose of protein shortage is vital. Many applications have been developed in performing disease detection such as an expert system for diagnosing diabetics and artificial neural network (ANN) applications for diagnosing breast cancer, acidosis diseases, and lung cancer. This paper is mainly focusing on the development of protein shortage disease diagnosing application using Backpropagation Neural Network (BPNN) technique. It covers two classes of protein shortage that are Heavy Protein Deficiency. On top of this, a BPNN model is constructed based on result analysis of the training and testing from the developed application. The model has been successfully tested using new data set. It shows that the BPNN is able to early diagnose heavy protein deficiency accurately. Keywords— Artificial Neural Network, Backpropagation Neural Network, Protein Deficiency.
Deteksi Dini Retinopati Diabetik dengan Pengolahan Citra Berbasis Morfologi Matematika
Authors: Heryawan Lukman 
Published: August 2017

Diabetic retinopathy is a complication caused by diabetes mellitus. Diabetic retinopathy, if not handled properly can lead to blindness. A necessary step to prevent blindness is early detection. Early detection can be done by finding the initial symptoms that microaneurysm. In this research, a system made to detect diabetic retinopathy using algorithms detection microaneurysm with mathematical morphology. The algorithm is divided into three stages of preprocessing, detecting candidate microaneurysm and postprocessing. In this research, the system will be made by using a raspberry pi as the media. To see how well the system detects diabetic retinopathy, the test will be done. in the tests performed, system obtained an accuracy of 90%, sensitivity 90, and specificity of 55% using data diaretdb1. While testing using data from e-ophtha obtained results with an accuracy of 70.5%, a sensitivity of 80% and a specificity of 60%.
Keanekaragaman Serangga Sebagai Pakan Alami Katak Tegalan (Fejervarya Limnocharis, Gravenhorst) pada Ekosistem Sawah di Desa Panggungharjo, Kecamatan Sewon, Kabupaten Bantul
Authors: Kuswantoro Farid , Soesilohadi R.C. Hidayat 
Published: August 2017

Paddy field was a dynamic and biodiversity rich ecosystems. Insect diversity in paddy field ecosystem was infected by paddy plant growth stages. Grass frog (Fejervarya limnocharis) ate insects as their natural prey. Insect population dynamics during vegetative, generative and reproductive stage of paddy plants infected F. limnocharis natural prey. This research aims were to study insect diversity and F. limnocharis insect prey diversity of vegetative, reproductive and generative paddy plant growth stages at Panggungharjo village, Sewon, Bantul. Insect sampling was conducted by direct survey method while F. limnocharis collection conducted by Visual Encounter Survey (VES) method. Ninety eight insect species from 51 different families and nine orders of insect were found. The orders were Coleoptera, Diptera, Hymenoptera, Odonata, Orthoptera, Dictyoptera, Dermaptera, Hemiptera and Lepidoptera. Stomachs analysis indicated F. limnocharis ate nine insect orders. The orders were Coleoptera, Diptera, Hymenoptera, Orthoptera, Dictyoptera, Dermaptera, Hemiptera, Lepidoptera and Isoptera. Most commonly insect prey in vegetative, reproductive and generative phase paddy growth stage were the members of the Order Coleoptera, Family Acrididae (Orthoptera) and Family Formicidae (Hymenoptera) respectively. This study concluded F. limnocharis main natural prey was the easily found and easily perceived insects.
Identifikasi Sifat dan Distribusi Sel Endokrin Ghrelin di Lambung Tikus (Rattus Norvegicus): Studi Immunohis-Tokimia pada Kondisi Obesitas
Authors: Budipitojo Teguh , Wihadmadyatami Hevi , Aristya Ganies Riza 
Published: August 2017

Obesity is one of major nutritional problems in the world. Obesity is very dangerous, especially when concentrated in the abdomen, because it is closely linked to various diseases such as diabetes, hypertension, heart disease, which can to causing death. This study aims to identify the nature and distribution of ghrelin on gastric endocrine cells in the obese rat (Rattus norvegicus) by using immunohistochemical techniques. The results will strengthen the understanding of the role and function of ghrelin as an alternative therapeutic target on obesity. The research used gastric tissues of ten obese and control rats which were stained with avidin-biotin-peroxidase complex method of immunohistochemistry. The results showed the existence of two types of ghrelin-producing cells (open and closed types) on the gastric mucosa of control rats, and only one type of ghrelin producing cells (open type) in obese rats. The intensity of ghrelin immunoreactive positive cells was detected weak in obese rats, but very strong in control rats. Ghrelin endocrine cells mainly distributed in the basal part of the gastric mucosa of the fundus parts, with a very small number in obese rats, but highly abundant in control rats. This study confirmed the decrease of the ghrelin synthesis and secretion in obese rat (Rattus norvegicus) at the cellular level. The decrease of ghrelin synthesis is characterized by a reduction on the number of ghrelin producing cells, the disappearance of the close type of ghrelin producing cells, and the low activity of protein synthesis in the ghrelin producing cells. Ghrelin endocrine cells distributed mainly in the basal part of the gastric mucosa, especially in the fundus parts.
Isolation and Characterization of Lactic Acid Bacteria from Inasua
Authors: Mahulette Ferymon , Mubarik Nisa Rachmania , Suwanto Antonius , Widanarni Widanarni 
Published: August 2017

Inasua is a traditionally product of wet salt fish fermentation produced by Teon, Nila and Serua (TNS) Communities in Central Maluku, Indonesia. The community made this fermented fish to anticipate the lean time when fisherman could not go to sea. The fish that used as inasua raw material is demersal fishes that live around coral reefs, such as Samandar fish (Siganatus guttatus), Gala-gala fish (Lutjanus sp.) and Sikuda fish (Lethrinus ornatus). The objective of the research was to isolate and characterize of bacterial indigenous in Inasua from three producers in Seram Island. The measurement of pH from inasua samples were 5.9, 5.0 and 5.8, respectively. The highest number of lactic acid bacteria was found from Gala – gala inasua was 2,5x107 cfu/g sample. Isolation of all isolates bacteria from inasua showed that a total of 7 isolates of bacteria was obtained from Samadar inasua, 9 isolates from Gala-gala inasua, and 7 isolates from Sikuda inasua. From a total of 23 isolates, only 6 isolates had characteristic as lactic acid bacteria that were Gram positive, negative catalase, and cocci shape. The microscopic characteristics of the isolates are coccid in pairs or uniforms which combine to form tetrads. Carbohydrate utilization test of selected isolate by using API 50 CHB kit indicated that 13 carbohydrates are fermented by these isolates after incubation for 48 hours. The research was concluded that the dominant bacteria in inasua sample is cocci-lactic acid bacteria.Keywords : fermented fish, inasua, lactic acid bacteria, MRSA medium
Identidad psicológica y cultural de los sonorenses
Authors: Vera Noriega José Ángel , Laborín Álvarez Jesús Francisco , Domínguez Ibáñez Sandra Elvia , Peña Ramos Martha Olivia 
Published: August 2017

A partir de un estudio sobre la población en el centro del país en el que se emplearon las escalas de bienestar subjetivo (Anguas, 1997), autoconcepto (La Rosa, 1986), locus de control (La Rosa, Díaz y Andrade, 1986), orientación al logro (Díaz, Andrade y La Rosa, 1989), evitación al éxito (Espinosa y Reyes, 1991) y enfrentamiento a los problemas (Góngora, 1998), se procedió a investigar su validez y las diferencias por género, edad y educación en el estado de Sonora. Mediante un muestreo por cuota, edad , sexo y socialización, se seleccionaron 1000 personas pertenecientes a cinco grupos de edad: adolescentes (14-18), adolescentes tardíos (19-22), jóvenes adultos (23-30), adultos (31-38) y adultos tardíos (39-55). Los resultados evidenciaron la sensibilidad y precisión de las escalas, así como diferencias por grupo de edad, sexo, ocupación y escolaridad. Finalmente, se reafirma el papel que juega el bienestar subjetivo en la percepción de control y en los estilos de enfrentamiento que la persona manifiesta en las distintas situaciones o escenarios en los que participa.
Teknik Pengembangan Industri Ekotourisme Kota Batu Propinsi Jawa Timur Dalam Perspektif Kebijakan
Authors: Krisno Budiyanto Moch. Agus 
Published: August 2017

From the previous researches, the typology development of Batu City ecotourism potency (Budiyanto, 2006), ecotourism potency of Canggar (Budiyanto, 2005-a). Nevertheless, the technical for ecotourism development industries in Batu City based on policy perspective has not been explored further. For this reason, this research aims at finding the the development of Batu City ecotourism in policy perspective. To achieve this aim, the scopes of this research is the technical for ecotourism development industries in Batu City based on policy perspective. The design of research used in this research is qualitative research (fenomenologys). The subject is adalah Batu City Planing dan Development Office and Batu City Tourism Office. The data collection method used is documentation and interview. The data was analyzed qualitatively (Content Analysis) by means of interactive model from Miles and Huberman (Miles & Huberman, 1994). The result of the analysis was presented in the form of cross tabulation and the narration from the phenomena. From the research finding the technical for ecotourism development industries in Batu City bassed on policy perspective included The International Ecotoursm Society and Mader is good. Generaly The International Ecotourism Society and Mader indicator was development in policy perspective.
Prioritas Pengembangan Industri Dengan Pendekatan Competitive Priorities
Authors: Lasalewo Trifandi 
Published: August 2017

In the process of developing competitive advantages of industry in one area, it is required that order of priority of industrial development policies be based on certain criteria/dimensions in which this order is based on the orientation and development plan according to the perspective of the stakeholders in that area. The competitive advantages are related to the purposes of industry in achieving its best performance and the strategy to be applied so that an industry possesses characteristics of competitive advantages that can survive/win business competition. As a new area, Gorontalo Province requires a scale of priority that can be made as a reference and industrial development plan in the future. The research model constitutes the results of several models of competitive priorities that have been established in several new industrialized countries; meanwhile the research object was focused on Small Medium Industry (SMIs) considering that SMIs are the biggest industrial group in Gorontalo Province. Based on the survey and results of data processing using. The Law of Comparative Judgment (LCJ) method, there are 7 (seven) dominant dimensions that should be considered in developing industry;namely, Quality, Cost/Price, Delivery, Customer Focus, Flexibility, Innovativeness and MarketOrientation. This order of competitive priorities can also be applied in other areas consideringthat the characters of SMI that are the object of the research are in principle the same as thoseof the SMI in other areas of Indonesia.
Pencapaian Performa Pada Katup Variabel Timing Fixed Timing Untuk Mesin Yang Optimal
Authors: Astawa Ketut 
Published: August 2017

Problems will be discussed in this research is how differences in exhaust emissions generated by engine with variable valve timing and valve timing on a fixed volume of motor vehicle cylinder 1300 cc. Variable valve timing technology, which is set when opening and closing the intake valve (intake valve) electronic fuel according to engine conditions. This will make mixing air and fuel that enters into an efficient machine that will produce great power, fuel economy and low emissions. Research emissions (CO, CO2, HC, O2) was performedwith dynamic testing, where the vehicle in a state of the load lifted and given transmission. Unlike the testing generally performed with a static test, in which the vehicle is at rest and without a load. This test is performed to determine how the condition of exhaust gases when the vehicle dynamic (analogous to the vehicle running). In general, machines with variable valve timing to produce better emissions than engines with fixed valve timing. The higher the spin machine and load transmission system will result in CO and HC emissions are decreased and O2 and CO2 increased. Engine with variable valve timing control the suction valve opening times to achieve optimum engine performance at various driving conditions. And set out the engineoutput as needed.
Perancangan Sasaran Mutu Lembaga Sertifikasi Personel Dengan Balance Scorecard
Authors: Sumaedi Sik , Yarmen Medi 
Published: August 2017

ISO/IEC 17024 directs Bodies Operating Certification of Person to adopt documented quality management system according to ISO 9001:2008. Bodies Operating Certification of Person that implement ISO 9001 documentation system should have quality objective. Quality objective is wished to be appropriated with institution performance indicators.Therefore, when quality objective is achieved, the institution performance is also good. The problem is quality objective in ISO 9001 is generally explained. This condition pushes Bodies Operating Certification of Person to identify the appropriate quality objective framework. Balance Score Card, a strategic performance measurement management framework that consist of 4 perspectives (financial, customer, internal process, learning and growth) that effectively proven could be solution for that problem. This research is to implement Balance Score Card performance management framework in Bodies Operating Certification of Person’s quality objective. This research is important considering there is no previous research that implement Balance Score Card in a Bodies Operating Certification of Person. The research result shows Balance Score Card based quality objective design with totally 12 quality objectives that consist of 1 financial perspective’s quality objective, 5 customer perspective’s quality objectives, 3 internal process perspective’s quality objectives, and 3 learning and growth perspective’s quality objectives.