bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Validation of Post-Treatment Outcomes of Adults Who Stutter Who Participated in the Blank Center CARE™Model Treatment: Replication and Extension
Authors: Coalson Geoffrey A. , Byrd Courtney T. 
Published: October 2024

AbstractPurposeSocial validation of treatment outcomes provides external validity of treatment from the perspective of untrained observers. To date, clinical efficacy studies of the Blank Center CARE Model indicate post-treatment gains in communication competence from the perspective of the participants and clinicians. An initial social validation study corroborated positive self- and clinician-rated treatment ratings with ratings from the general public for a single participant. The present study was designed to replicate and extend these findings by assessing clinical outcomes from the perspective of untrained observers across multiple participants and contexts.MethodTen adults who stutter provided communication samples one week before and after completing the Blank Center CARE Model treatment. A total of 1,110 untrained observers were recruited. Each untrained observer rated only one participant at one timepoint (pre-treatment or post-treatment) in one context (dyad or presentation), and each participant was asked to provide only one rating (communication competence or stuttering severity).ResultsA significant interaction indicated that post-treatment gains were observed for communication competence, but not stuttering severity, for both contexts.ConclusionsPresent findings provide further social validation of the Blank Center CARE Model of treatment. Untrained observers confirmed that participation in this strengths-based approach significantly enhances communication competence. Notably, these changes were observed regardless of pre- to post-treatment stuttering severity, lending additional support to the premise that communication and fluency are independent constructs.
Mutations of schizophrenia risk geneSETD1Adysregulate synaptic function in human neurons
Authors: Su Xiao , Zhang Hanwen , Hong Yan , Yang Qian , Wang Le , Le Tiffany , Liu Jiayi , Cheruvu Lasya , Labour Emily , Zhang Siwei , Mendez-Maldonado Karla , Kreimer Anat , Song Hongjun , Ming Guo-li , Duan Jubao , Pang Zhiping P. 
Published: October 2024

AbstractSchizophrenia (SCZ) is a complex neuropsychiatric disorder associated with both common risk variants of small effect sizes and rare risk variants of high penetrance. Rare protein truncating variants (PTVs) inSETD1A(SET Domain Containing 1A) show a strong association with SCZ; however, it remains largely unclear how rare PTVs inSETD1Acontribute to the pathophysiology of SCZ. To understand the impact ofSETD1Arare PTVs in human neurons, we CRISPR/Cas9-engineered five isogenic pairs of human induced pluripotent stem cells (iPSCs), with a recurrent heterozygous patient-specific PTV mutation c.4582-2delAG in two donor lines and a heterozygous frameshift mutation c.4596_4597insG (p. Leu1533fs) in three donor lines. These two mutations are predicted to cause a premature stop codon in exon 16 ofSETD1A, leading to the loss of the conserved SET domain that is critical for its histone methyltransferase activity. We found that these presumably loss-of-function (LoF) mutations caused theSETD1AmRNAs to be degraded by nonsense-mediated decay (NMD), accompanied by a reduction of full-length SETD1A protein level in iPSCs. We then characterized the morphological, electrophysiological, and transcriptomic impacts of theSETD1A+/-LoF mutations in iPSC-derived human excitatory neurons induced by NGN2. We found that theSETD1A+/-exon-16 LoF mutations altered dendrite complexity, dysregulated synaptic transmission, and synaptic plasticity, likely by dysregulating genes involved in synaptic function. These results provide mechanistic insights into howSETD1A+/-exon-16 patient-specific LoF mutations affect neuron phenotypes that may be relevant to the pathophysiology of SCZ.
Live-HPF CLEM using the HPM Live µ: Finding back all needles in every haystack. The last frontier in CLEM
Authors: Heiligenstein Xavier , Kodera Chie , Bret Yann , Eyraud Frederic , Muczynski Vincent , Heiligenstein Jérôme , Belle Martin 
Published: October 2024

AbstractCorrelative light and electron microscopy is a scientific method that encompasses several technologies and workflows. One of the pioneering workflows consisted in vitrifying by high pressure freezing a sample, shortly after live observation1. Despite its extraordinary potential, it did not turn into a routine technique for practical reasons. We redesigned the entire tool set, from the sample carrier to the high-pressure freezing machine, to standardize and democratise the technique. In our manuscript, we present all the technological developments that lead to a routine workflow for live to HPF CLEM. We demonstrate our ability to track rapidly moving endosomes live and retrieve them at the electron microscopy level, in three dimensions, with high confidence.
Apical clathrin-coated pits control the location, timing, and scale of microvillar growth
Authors: Perkins Olivia L. , Mulligan Alexandra G. , Krystofiak Evan S. , Peebles K. Elkie , Nagarajan Rekha N. , Meenderink Leslie M. , Millis Bryan A. , Tyska Matthew J. 
Published: October 2024

SUMMARYEpithelial cells from diverse contexts assemble apical specializations to serve tissue-specific functions. In virtually all cases, these features consist of arrays of microvilli: micron-scale, actin bundle-supported protrusions that mediate biochemical and physical interactions with the external environment. Despite their importance for epithelial physiology, how microvilli grow during cellular differentiation remains poorly understood. Using genetic and small molecule perturbations, we found that an epithelial cell’s potential for growing microvilli of normal size is limited by an adjacent actin-dependent process: apical clathrin-mediated endocytosis. Unexpectedly, timelapse imaging of individual microvillar growth events revealed tight spatial and temporal coupling to sites of clathrin-mediated endocytosis. Ultrastructural characterization of undifferentiated epithelial monolayers also showed that most nascent microvilli are in contact with an apical endocytic pit. Finally, inhibition of the Arp2/3 branched nucleation complex, which drives actin polymerization on coated pits, significantly reduced the accumulation of new microvilli on the surface of differentiating epithelial cells. Based on these discoveries, we conclude that clathrin-mediated endocytosis and its associated Arp2/3-based actin nucleation activity control the timing and location of microvillar growth, as well as the dimensions of the resulting protrusions.
A numerical study of double flow focusing micro-jets
Authors: Zahoor Rizwan , Bajt Saša , Šarler Božidar 
Published: October 2024

Purpose
Double flow-focusing nozzles (DFFNs) form a coaxial flow of primary liquid with micro-crystalline samples, surrounded by secondary liquid and focusing gas. This paper aims to develop an experimentally validated numerical model and assess the performance of micro-jets from a DFFN as a function of various operating parameters for the water–ethanol–helium system, revealing the jet's stability, diameter, length and velocity.

Design/methodology/approach
The physical model is formulated in the mixture-continuum formulation, which includes coupled mass, momentum and species transport equations. The model is numerically formulated within the finite volume method–volume of fluid approach and implemented in OpenFOAM to allow for a non-linear variation of the fluid's material properties as a function of the mixture concentration. The numerical results are compared with the experimental data.

Findings
A sensitivity study of jets with Reynolds numbers between 12 and 60, Weber numbers between 4 and 120 and capillary numbers between 0.2 and 2.0 was performed. It was observed that jet diameters and lengths get larger with increased primary and secondary fluid flow rates. Increasing gas flow rates produces thinner, shorter and faster jets. Previously considered pre-mixed and linear mixing models substantially differ from the accurate representation of the water–ethanol mixing dynamics in DFFNs. The authors demonstrated that Jouyban–Acree mixing model fits the experimental data much better.

Originality/value
The mixing of primary and secondary liquids in the jet produced by DFFN is numerically modelled for the first time. This study provides novel insights into mixing dynamics in such micro-jets, which can be used to improve the design of DFFNs.
Mired in tasks: how daily workplace multitasking shapes employee service innovation behavior
Authors: Xie Peng , Tian Fen Fen 
Published: October 2024

Purpose
Drawing on conservation of resources theory, this paper aims to propose that daily multitasking increases employees’ daily role pressure, ultimately hindering their service innovation behavior. Furthermore, we suggest that trait mindfulness may mitigate this negative impact.

Design/methodology/approach
To empirically test the study hypotheses, this paper conducted a multilevel diary field study, collecting data from 64 employees over 10 working days to comprehensively validate the theoretical model.

Findings
The findings indicate that daily multitasking indirectly reduces daily service innovation behavior by increasing employee role pressure. Notably, this indirect effect is more pronounced among employees with lower trait mindfulness, while it is less significant for those with higher trait mindfulness.

Practical implications
Hotels should manage multitasking, reduce employee stress and promote service innovation by optimizing task allocation and redesigning work processes. Additionally, hotel management should adopt a multifaceted and innovative approach to foster mindfulness traits.

Originality/value
This study contributes to the literature on multitasking and innovation by examining how and when daily multitasking influences employee service innovation behavior.
A self-organizing map clustering adaptive artificial neural network model for analysis critical success factors in different phases of MTO projects case study: electrical equipment manufacturer and supplier in Iran
Authors: Shirouyehzad Hadi , Kashian Elham , Emadi Saeed 
Published: October 2024

PurposeThe purpose of this paper is to investigate the benefit of critical success factors (CSFs) clustering in different phases of make-to-order (MTO) projects and develop standards for management.Design/methodology/approachThis study is based on a questionnaire survey. First of all, collecting data by structured interviews, relying on a questionnaire and second from leader contractors who are active in the engineering and steel industry (in Iran). So, the requirements and objective of the research are presented to the top management of MTO projects to gain their support in data collection. Then 20 CSFs were identified by the literature review so a questionnaire survey was prepared for the CSFs assessment and interview with the experts. Finally analyzing the importance and performance of CSFs in project phases and cluster them in different project phases with self-organizing map as one of the artificial neural network (ANN) approaches due to high predictive accuracy. Review the research result with the top management of MTO project and examine the results obtained from neural networks and validation indices.FindingsCluster analysis shows that the implementation phase is the most important stage in MTO organizations and the other phases like feasibility and start-up, design and planning, delivery and end-phase should be also considered as effective phases in determining the level of organization performance. Different industries with additional data at different periodic times will verify the result. Furthermore, testing the other ANN model will improve risk analysis and could shift this classification approach to a regression type.Research limitations/implicationsThe main limitation of the research is related to the sample. Research findings are limited to the time of data collection so validity is limited to the mentioned time. Different industries with additional data will verify the result. Furthermore, testing different ANN models such as K-MEANS, non-negative matrix factorization (NMF) analyses will improve risk analysis and could meet different classification results to find gaps.Practical implicationsIn this paper, CSF and project phase dimensions are viewed together which is necessary to meet better results for simplifying social and economic benefits. Merge the new findings and latest technologies could prepare the best results and enable managers to create a better framework or implement key factors for minimizing waste.Originality/valueThis paper moves the definition of MTO organizations beyond measuring cost, complexity and financial variables by clustering CSFs in different phases of projects. So, the results enable managers to use this concept in their daily production to minimize waste and could be implemented to efficiently choose factors.
Adoption of cloud-based accounting solutions in micro, small and medium-sized enterprises: insights from the Kingdom of Saudi Arabia
Authors: Alshenaifi Zeyad , El Sayad Samar 
Published: October 2024

Purpose
This study aims to explore the extent to which micro, small and medium-sized enterprises (MSMEs) in Saudi Arabia are adopting cloud-based accounting systems, what cloud accounting technologies MSMEs are using and the factors that affect cloud accounting system adoption. The technology, organizational and environmental model was used to assess the factors that affect the adoption of cloud accounting systems.

Design/methodology/approach
Data were collected via a survey distributed to MSME owners, directors and chief executives in Saudi Arabia. The final sample comprised 174 participants. Descriptive statistics, multiple response analysis and logistic regression were used to analyze the data.

Findings
This study’s findings show that many MSMEs currently do not use cloud accounting. The findings also show that Sage One and Xero Accounting are the main cloud accounting technologies MSMEs use. Perceived benefits, security concerns, organizational readiness, government support and vendor support were found to significantly influence the adoption of cloud accounting systems, while compatibility, firm size, top management support and intensity of the competition were not found to affect MSMEs adoption of cloud accounting technologies.

Originality/value
To the best of the authors’ knowledge, this study is the first to explore cloud accounting adoption by MSMEs in Saudi Arabia. It empirically shows the extent to which cloud-based accounting systems are used in MSMEs and the significant factors influencing the adoption of these systems.
From social media marketing to sustainable tourism development: how functionalities and destination image support sustainable tourism development
Authors: Fathy Doaa , Naguib Hend M. , Elsharnouby Mohamed H. , Shazly Rana Essam 
Published: October 2024

PurposeThis study investigates the influence of social media marketing (SMM) functionalities on perceived destination image (DI) and its dimensions, which in turn impact residents’ support for sustainable tourism development (SSTD). The study also examines the moderated mediation effect of the residency length and resident’s income in the indirect relationship between SMM and SSTD through the DI.Design/methodology/approachThe best technique found appropriate for this study was the survey approach. To gather empirical data, people who currently reside in Alexandria completed 351 questionnaires via an online survey. The questionnaire was translated into Arabic while adhering to back-translation guidelines. SPSS and AMOS software were used to analyze the collected data.FindingsIt is found that there is a direct effect of SMM and its functionalities on overall DI and its dimensions. In addition, DI mediates the relationship between SMM and SSTD. These results hold valuable insights for academicians and practitioners in the tourism industry, potentially informing SMM strategies to support tourism activities.Originality/valueThis research introduces a novel framework emphasizing the functionalities of the SMM as a tool for enhancing both affective and cognitive DI and supporting sustainable tourism development. It contributes to the SMM and SSTD literature by examining the links between SMM functionalities and sustainable tourism development in emerging countries such as Egypt.
Mentoring student teachers during practicum: exploring experiences and limitations
Authors: Mpate Hawa Mohamed 
Published: October 2024

PurposeThis study aims to delve into experiences and challenges impeding effective mentoring in three secondary schools where student teachers were placed for their practicum in Tanzania.Design/methodology/approachThe study adopted a qualitative approach, employing interviews and focus group discussions to gather data from 31 participants, including mentor teachers, heads of schools, supervisors and student teachers.FindingsThe findings revealed that poor communication, inadequate understanding of effective mentoring practices, improper mentor-teacher recruitment processes, mentors’ unwillingness to engage in mentoring and divergence of expectations were significant challenges to effective mentoring on practicum.Originality/valueThe study gives new insights into the existing research on the potential challenges impeding mentoring and appropriate solutions to address them and improve the practicum experience in the Tanzanian teacher education system.
Bringing brain into the game: introducing the brain-based view of dynamic capabilities
Authors: Kaur Vaneet 
Published: October 2024

Purpose
Change lies at the heart of the dynamic capability theory; however, the essence of concept of change is antithetical to the brain's predominant mode of operation i.e. maintenance of internal homeostasis. Since very little is known about the connection between neurology and dynamic capabilities, the present study aims to open this black box and propose a novel brain-based view of developing dynamic capabilities.

Design/methodology/approach
This study draws on the insights from neuroscience to offer propositions that not only provide realistic approaches for building dynamic capabilities, but also explain what would cause the brain to enter a state of plasticity to facilitate the development of managerial dynamic capabilities.

Findings
This study explains that dynamic capabilities are shaped by both lower-level neural processes and higher-level organizational processes, and that both these levels must be brought together to provide a holistic explanation about the complex phenomena of dynamic capabilities.

Originality/value
This study proposes a novel brain-based view of dynamic capabilities that provides neuroscientific explanations regarding how managerial capabilities can be leveraged to form organization-level capabilities without holding a priori assumptions about the application of the aggregation principle.
Oral administration of ruxolitinib in psoriasis vulgaris: A case report of plaque psoriasis accompanied by myelofibrosis secondary to polisitemia vera successfully treated with oral ruxolitinib
Authors: Çetinarslan Tubanur , Aydoğdu İsmet , Ermertcan Aylin Türel 
Published: October 2024

AbstractPsoriasis is a chronic inflammatory skin disease characterized by keratinocyte hyperproliferation and immune cell infiltration. Various therapies have been discovered for psoriasis, including topical treatments, phototherapy, conventional systemic agents such as methotrexate, retinoids and ciclosporine, as well as biologics. Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway inhibitors targeting Tumor Necrosis Factor alpha (TNF‐α), interleukin (IL)‐23 and IL‐17 can be effective in psoriasis. Ruxolitinib is a US Food and Drug Administration‐approved first‐generation Janus kinase inhibitor for polycythemia vera, myelofibrosis, and acute graft‐versus‐host disease. Ruxolitinib cream has been investigated in various dermatologic diseases, including atopic dermatitis, vitiligo, psoriasis, and alopecia areata. However, there is limited data on the efficacy of oral ruxolitinib in patients with psoriasis vulgaris. Here, we report a patient diagnosed with myelofibrosis coexisting with psoriasis vulgaris, successfully treated with oral ruxolitinib.
The potential for species distribution models to distinguish source populations from sinks
Authors: Şen Bilgecan , Che‐Castaldo Christian , Akçakaya H. Reşit 
Published: October 2024

Abstract

While species distribution models (SDM) are frequently used to predict species occurrences to help inform conservation management, there is limited evidence evaluating whether habitat suitability can reliably predict intrinsic growth rates or distinguish source populations from sinks. Filling this knowledge gap is critical for conservation science, as applications of SDMs for management purposes ultimately depend on these typically unobserved population or metapopulation dynamics.

Using linear regression, we associated previously published population level estimates of intrinsic growth and abundance derived from a Bayesian analysis of mark‐recapture data for 17 bird species found in the contiguous United States with SDM habitat suitability estimates fitted here to opportunistic data for these same species. We then used the area under the ROC curve (AUC) to measure how well SDMs can distinguish populations categorized as sources and sinks. We built SDMs using two different approaches, boosted regression trees (BRT) and generalized linear models (GLM), and compared their source/sink predictive performance. Each SDM was built with presence points obtained from eBird (a web‐available database) and 10 environmental variables previously selected to model intrinsic growth rates and abundance for these species.

We show that SDMs built with opportunistic data are poor predictors of species demography in general; both BRT and GLM explained very little spatial variation of intrinsic growth rate and population abundance (median R2 across 17 species was close to 0.1 for both SDM methods). SDMs, however, estimated higher suitability for source populations as compared to sinks. Out of 13 species which had both source and sink populations, both BRT and GLM had AUC values greater than 0.7 for 7 species when discriminating between sources and sinks.

Habitat suitability have the potential to be a useful measure to indicate a population's ability to sustain itself as a source population; however more research on a diverse set of taxa is essential to fully explore this potential. This interpretation of habitat suitability can be particularly useful for conservation practice, and identification of explicit cases of when and how SDMs fail to match population demography can be informative for advancing ecological theory.