bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entwicklung und Aufbau eines Probenhalters für die Emissionsgradmessung an semitransparenten Materialien
Authors: Gieseler Julian , Monte Christian , Adibekyan Albert , Hollandt Jörg , Kersting Robert 
Published: November 2017

Zusammenfassung
An der Physikalisch-Technischen Bundesanstalt (PTB) wurden die vorhandenen Messanlagen zur Emissionsgradmessung um die
Möglichkeit der Messung des Emissionsgrads an semitransparenten Materialien erweitert. Ein für diesen Zweck
geeigneter Probenhalter wurde entworfen, durch Simulationen optimiert und realisiert. Einige Bauteile, die teilweise eine
komplexe interne Struktur aufweisen, wurden durch selektives Laserschmelzen im Pulverbett (SLM) gefertigt. Zur Auswertung
der mit dem neuen Probenhalter gewonnenen Daten wurde ein vereinfachtes Strahlungstransportmodell aufgestellt.
Influence of Team Rating on Running Performance in Elite Gaelic Football
Authors: Mangan Shane , Malone Shane , Ryan Martin , Mc Gahan Jason , Warne Joe , Martin Denise , O'Neill Cian , Burns Con , Collins Kieran 
Published: November 2017

Abstract
Mangan, S, Malone, S, Ryan, M, Mc Gahan, J, Warne, J, Martin, D, O'Neill, C, Burns, C, and Collins, K. Influence of team rating on running performance in elite Gaelic football. J Strength Cond Res 32(9): 2584–2591, 2017—It is currently unknown how team rating influences running performance in Gaelic football. Global positioning system technologies were used to quantify match-running performance within 5 elite Gaelic football teams over a period of 5 years (2012–2016). In total 780 player data sets were collected over 95 matches. Running performance variables included total distance, high-speed distance (≥17 km·h−1), and the percentage of high-speed distance. Team ratings were determined objectively using the Elo rating system for Gaelic football. Reference team rating had trivial effects on total distance (p = 0.011, partial η2 = 0.008) and high-speed distance (p = 0.011, partial η2 = 0.008). Opposition team rating had small effects on total distance (p = 0.005, partial η2 = 0.016) and high-speed distance (p = 0.001, partial η2 = 0.020). Top-tier teams cover greater total distances and high-speed distance than lower tier teams. Players cover considerably less total distance and high-speed distance against tier-3 and tier-4 teams. Tier-1 players ran a significantly higher percentage of distance at high speed than players who played for tier-2 teams (p = 0.020). The competitive advantage of top-tier Gaelic football teams is closely linked with their ability to demonstrate a higher physical intensity than lower tier teams.
Sequencing Effects of Neuromuscular Training on Physical Fitness in Youth Elite Tennis Players
Authors: Fernandez-Fernandez Jaime , Granacher Urs , Sanz-Rivas David , Sarabia Marín Jose Manuel , Hernandez-Davo Jose Luis , Moya Manuel 
Published: November 2017

Abstract
Fernandez-Fernandez, J, Granacher, U, Sanz-Rivas, D, Sarabia Marín, JM, Hernandez-Davo, JL, and Moya, M. Sequencing effects of neuromuscular training on physical fitness in youth elite tennis players. J Strength Cond Res 32(3): 849–856, 2018—The aim of this study was to analyze the effects of a 5-week neuromuscular training (NMT) implemented before or after a tennis session in prepubertal players on selected components of physical fitness. Sixteen high-level tennis players with a mean age of 12.9 ± 0.4 years participated in this study, and were assigned to either a training group performing NMT before tennis-specific training (BT; n = 8) or a group that conducted NMT after tennis-specific training (AT; n = 8). Pretest and posttest included: speed (5, 10, and 20 m); modified 5-0-5 agility test; countermovement jump (CMJ); overhead medicine ball throw (MBT); and serve velocity (SV). Results showed that the BT group achieved positive effects from pretest to posttest measures in speed (d = 0.52, 0.32, and 1.08 for 5, 10, and 20 m respectively), 5-0-5 (d = 0.22), CMJ (d = 0.29), MBT (d = 0.51), and SV (d = 0.32), whereas trivial (10 m, 20 m, CMJ, SV, and MBT) or negative effects (d = −0.19 and −0.24 for 5 m and 5-0-5, respectively) were reported for the AT group. The inclusion of an NMT session before the regular tennis training led to positive effects from pretest to posttest measures in performance-related variables (i.e., jump, sprint, change of direction capacity, as well as upper-body power), whereas conducting the same exercise sessions after the regular tennis training was not accompanied by the same improvements.
Effect of Cold-Water Immersion on Elbow Flexors Muscle Thickness After Resistance Training
Authors: Matos Filipe , Neves Eduardo B. , Rosa Claudio , Reis Victor M. , Saavedra Francisco , Silva Severiano , Tavares Francisco , Vilaça-Alves José 
Published: November 2017

Abstract
Matos, F, Neves, EB, Rosa, C, Reis, VM, Saavedra, F, Silva, S, Tavares, F, and Vilaça-Alves, J. Effect of cold-water immersion on elbow flexors muscle thickness after resistance training. J Strength Cond Res 32(3): 756–763, 2018—Cold-water immersion (CWI) is commonly applied to speed up the recovery process after exercise. Muscle damage may induce a performance reduction and consequence of the intramuscular pressure induced by the muscular swelling. The aim of the study was to verify the CWI effects on muscle thickness (MT) behavior of the elbow flexors after a strength training (ST) protocol. Eleven men were submitted to an ST, performed in 2 different weeks. In one of the weeks, subjects experienced a passive recovery. In the other, subjects were submitted to a CWI (20 minutes at 5–10° C). Ultrasound (US) images were taken before, after, as well as 24, 48, and 72 hours after exercise, to evaluate the MT. Muscle thickness in both exercise arm (EA) and control arm (CA) was significantly higher 48 and 72 hours after exercise when subjects were submitted to a passive recovery compared with the CWI (p = 0.029, p = 0.028, p = 0.009, and p = 0.001, 48 hours, 72 hours, EA, and CA, respectively). When each arm was analyzed with or without using CWI individually, significantly higher MT was observed in the EA with CWI: before exercise in relation to 72 hours after exercise (p = 0.042) and after exercise in relation to the other measurements (p = 0.003, p = 0.003, p = 0.038, and p < 0.0001, before exercise and 24, 48, 72 hours after exercise, respectively). The evaluation of MT by US provides evidence that CWI after ST (and 24 hours after exercise) may reduce muscle swelling in the postexercise days when compared with a passive recovery. Seems to be a paradox between the uses of CWI for an acute reduction of muscle swelling.
Validity and Reliability of a New Test of Planned Agility in Elite Taekwondo Athletes
Authors: Chaabene Helmi , Negra Yassine , Capranica Laura , Bouguezzi Raja , Hachana Younés , Rouahi Mohamed Ali , Mkaouer Bessem 
Published: November 2017

Abstract
Chaabene, H, Negra, Y, Capranica, L, Bouguezzi, R, Hachana, Y, Rouahi, MA, and Mkaouer, B. Validity and reliability of a new test of planned agility in elite taekwondo athletes. J Strength Cond Res 32(9): 2542–2547, 2018—This study aimed to examine the validity, reliability, and sensitivity of a new test of planned agility in elite taekwondo athletes and to establish its relationship with sprint-time, jumping ability, and dynamic balance. Twenty-seven (20 males and 7 females) taekwondo athletes participated in this study. They performed taekwondo-specific agility test (TSAT) in 2 occasions (i.e., test-retest). In addition, they performed jumping ability (i.e., squat jump, countermovement jump, standing long jump, and 3-hop jump), sprint-time (5- and 20-m dash), and dynamic balance (i.e., Y-test) tests along with a planned agility test (i.e., T-test). To establish TSAT's construct validity, 2 subgroups were identified based on their international and national taekwondo results: top elite (9 males and 2 females) and elite (11 males and 2 females). Taekwondo-specific agility test showed high relative and absolute reliability as well as a good ability to detect small and meaningful performance change. Top-elite athletes showed greater (p < 0.001) TSAT performances (4.5 ± 0.4 seconds) compared with their elite (5.3 ± 0.4 seconds) counterparts. Receiving operating characteristic (ROC) analysis showed that TSAT was able to discriminate athletes of different competitive level as revealed by an area under the ROC curve of 0.94 (95% confidence interval: 0.76–0.99). Taekwondo-specific agility test demonstrated significant association with the T-test (r = 0.71; shared variance = 50%), which is considered as a gold-standard planned agility test. In addition, results showed moderate-to-large associations between TSAT and jumping ability, sprint-time, and dynamic balance tests. The TSAT might be considered as a valid and reliable test to evaluate specific agility of taekwondo athletes.
Acute Capsaicin Supplementation Improves 1,500-m Running Time-Trial Performance and Rate of Perceived Exertion in Physically Active Adults
Authors: de Freitas Marcelo Conrado , Cholewa Jason M. , Gobbo Luis A. , de Oliveira João V.N.S. , Lira Fabio S. , Rossi Fabrício E. 
Published: November 2017

Abstract
de Freitas, MC, Cholewa, JM, Gobbo, LA, de Oliveira, JVNS, Lira, FS, and Rossi, FE. Acute capsaicin supplementation improves 1,500-m running time-trial performance and rate of perceived exertion in physically active adults. J Strength Cond Res 32(2): 572–577, 2018—The purpose of this study was to investigate the acute effect of capsaicin supplementation on performance, rate of perceived exertion (RPE), and blood lactate concentrations during short-duration running in physically active adults. Ten physically active men (age = 23.5 ± 1.9 years, mass = 78.3 ± 12.4 kg, and height = 177.9 ± 5.9 cm) completed 2 randomized, double-blind trials: Capsaicin condition (12 mg) or a placebo condition. Forty-five minutes after supplement consumption, the participants performed a 1,500-m running time trial. Time (in seconds) was recorded. Blood lactate concentration was analyzed at rest, immediately after exercise, after 5, 10, and 30 minutes during recovery and the RPE was collected after exercise. The time was significantly (t = 3.316, p = 0.009) lower in the capsaicin (371.6 ± 40.8 seconds) compared with placebo (376.7 ± 39 seconds). Rate of perceived exertion was significantly (t = 2.753, p = 0.022) less in the capsaicin (18.0 ± 1.9) compared with the placebo (18.8 ± 1.3). Lactate increased across time for both conditions without significant differences between (p > 0.05). In summary, acute capsaicin supplementation improves middle distance running (1,500 m) performance and reduced RPE in physically active adults.
A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau MutationsIn Vivo
Authors: Bardai Farah H. , Wang Liqun , Mutreja Yamini , Yenjerla Mythili , Gamblin T. Chris , Feany Mel B. 
Published: November 2017

The microtubule binding protein tau is strongly implicated in multiple neurodegenerative disorders, including frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), which is caused by mutations in tau.In vitro, FTDP-17 mutant versions of tau can reduce microtubule binding and increase the aggregation of tau, but the mechanism by which these mutations promote diseasein vivois not clear. Here we take a combined biochemical andin vivomodeling approach to define functional properties of tau driving neurotoxicityin vivo. We express wild-type human tau and five FTDP-17 mutant forms of tau inDrosophilausing a site-directed insertion strategy to ensure equivalent levels of expression. We then analyze multiple markers of neurodegeneration and neurotoxicity in transgenic animals, including analysis of both males and females. We find that FTDP-17 mutations act to enhance phosphorylation of tau and thus promote neurotoxicity in anin vivosetting. Further, we demonstrate that phosphorylation-dependent excess stabilization of the actin cytoskeleton is a key phosphorylation-dependent mediator of the toxicity of wild-type tau and of all the FTDP-17 mutants tested. Finally, we show that important downstream pathways, including autophagy and the unfolded protein response, are coregulated with neurotoxicity and actin cytoskeletal stabilization in brains of flies expressing wild-type human and various FTDP-17 tau mutants, supporting a conserved mechanism of neurotoxicity of wild-type tau and FTDP-17 mutant tau in disease pathogenesis.SIGNIFICANCE STATEMENTThe microtubule protein tau aggregates and forms insoluble inclusion bodies known as neurofibrillary tangles in the brain tissue of patients with a variety of neurodegenerative disorders, including Alzheimer's disease. The tau protein is thus widely felt to play a key role in promoting neurodegeneration. However, precisely how tau becomes toxic is unclear. Here we capitalize on an “experiment of nature” in which rare missense mutations in tau cause familial neurodegeneration and neurofibrillary tangle formation. By comparing the biochemical activities of different tau mutations with theirin vivotoxicity in a well controlledDrosophilamodel system, we find that all mutations tested increase phosphorylation of tau and trigger a cascade of neurotoxicity critically impinging on the integrity of the actin cytoskeleton.
Complex History and Differentiation Patterns of the t-Haplotype, a Mouse Meiotic Driver
Authors: Kelemen Reka K , Vicoso Beatriz 
Published: November 2017

Abstract
The t-haplotype, a mouse meiotic driver found on chromosome 17, has been a model for autosomal segregation distortion for close to a century, but several questions remain regarding its biology and evolutionary history. A recently published set of population genomics resources for wild mice includes several individuals heterozygous for the t-haplotype, which we use to characterize this selfish element at the genomic and transcriptomic level. Our results show that large sections of the t-haplotype have been replaced by standard homologous sequences, possibly due to occasional events of recombination, and that this complicates the inference of its history. As expected for a long genomic segment of very low recombination, the t-haplotype carries an excess of fixed nonsynonymous mutations compared to the standard chromosome. This excess is stronger for regions that have not undergone recent recombination, suggesting that occasional gene flow between the t and the standard chromosome may provide a mechanism to regenerate coding sequences that have accumulated deleterious mutations. Finally, we find that t-complex genes with altered expression largely overlap with deleted or amplified regions, and that carrying a t-haplotype alters the testis expression of genes outside of the t-complex, providing new leads into the pathways involved in the biology of this segregation distorter.
Infant Neuromotor Development and Childhood Problem Behavior
Authors: Serdarevic Fadila , Ghassabian Akhgar , van Batenburg-Eddes Tamara , Tahirovic Emin , White Tonya , Jaddoe Vincent W.V. , Verhulst Frank C. , Tiemeier Henning 
Published: November 2017

BACKGROUND:
Research of adults and school-aged children suggest a neurodevelopmental basis for psychiatric disorders. We examined whether infant neuromotor development predicted internalizing and externalizing problems in young children.

METHODS:
In Generation R, a population-based cohort in the Netherlands (2002–2006), trained research assistants evaluated the neuromotor development of 4006 infants aged 2 to 5 months by using an adapted version of Touwen’s Neurodevelopmental Examination (tone, responses, and senses and other observations). We defined nonoptimal neuromotor development as scores in the highest tertile. Mothers and fathers rated their children’s behavior at ages 1.5, 3, 6, and 10 years with the Child Behavior Checklist (n = 3474, response: 86.7%). The associations were tested with generalized linear mixed models.

RESULTS:
Overall, neuromotor development predicted internalizing scores, but no association was observed with externalizing scores. Nonoptimal muscle tone was associated with higher internalizing scores (mothers’ report: β = .07; 95% confidence interval [CI]: 0.01 to 0.13; fathers’ report: β = .09, 95% CI: 0.00 to 0.16). In particular, nonoptimal low muscle tone was associated with higher internalizing scores (mothers’ report: β = .11; 95% CI: 0.05 to 0.18; fathers’ report: β = .13; 95% CI: 0.04 to 0.22). We also observed an association between senses and other observations with internalizing scores. There was no relationship between high muscle tone or reflexes and internalizing scores.

CONCLUSIONS:
Common emotional problems in childhood have a neurodevelopmental basis in infancy. Neuromotor assessment in infancy may help identify vulnerability to early internalizing symptoms and offer the opportunity for targeted interventions.
First Prospective Multicenter Italian Study on the Impact of the 21-Gene Recurrence Score in Adjuvant Clinical Decisions for Patients with ER Positive/HER2 Negative Breast Cancer
Authors: Dieci Maria Vittoria , Guarneri Valentina , Giarratano Tommaso , Mion Marta , Tortora Giampaolo , De Rossi Costanza , Gori Stefania , Oliani Cristina , Merlini Laura , Pasini Felice , Bonciarelli Giorgio , Griguolo Gaia , Orvieto Enrico , Michieletto Silvia , Saibene Tania , Del Bianco Paola , De Salvo Gian Luca , Conte PierFranco 
Published: November 2017

Abstract

Background
The Breast DX Italy prospective study evaluated the impact of the 21-gene recurrence score (RS) result on adjuvant treatment decisions for patients with early breast cancer.

Materials and Methods
Nine centers (two Hub and seven Spoke centers of the Veneto Oncology Network) participated. Consecutive patients with estrogen receptor positive, human epidermal growth receptor negative, T1–T3, N0–N1 early breast cancer were prospectively registered; only those meeting protocol-defined clinicopathological “intermediate risk” criteria were eligible for the RS test. Pre-RS and post-RS physicians’ treatment recommendations and treatment actually received were collected.

Results
A total of n = 124 N0 and n = 126 N1 patients underwent the RS assay. The majority had Grade 2 tumors (71%); median age was 55 years, median tumor size was 16 mm, and median Ki67 expression was 20%. Patients enrolled at Hub centers presented higher-risk features. The distribution of RS results was &lt;18 (60.8%), 18–30 (32.4%), and &gt;30 (6.8%). The indication before RS was hormonal therapy (HT) alone in 52% of cases. An indication before RS of chemotherapy (CT)+HT was more frequent for patients with N1 versus N0 tumors (57% vs. 39%, p = .0035) and for patients enrolled at Hub versus Spoke centers (54% vs. 36%, p = .007).
The overall rate of change in treatment decision was 16% (n = 40), mostly from CT+HT to HT (n = 30). According to nodal status, rate of change in treatment decision was 12% for the N0 cohort and 20% for the N1 cohort. The proportion of patients recommended to CT+HT was significantly reduced from before to after RS (48% to 40%, p &lt; .0016), especially in the N1 cohort (57% to 45%, p = .0027) and at Hub centers (54% to 44%, p = .001).

Conclusion
Despite frequent indication of HT before RS, the use of the RS assay further contributed to sparing CT, especially for patients with N1 tumors and at Hub centers.

Implications for Practice
This study shows that, although a high proportion of patients were recommended to receive endocrine treatment alone before knowing the recurrence score (RS) assay, the RS test further contributed in sparing chemotherapy for some of these patients, especially in case of the N1 stage or for patients enrolled at referral centers. These data highlight the need for further work in collaboration with health authorities and companies in order to define strategies for the implementation of the use of RS testing in clinical practice in the Italian setting.
Phase II Study of Bevacizumab and Vorinostat for Patients with Recurrent World Health Organization Grade 4 Malignant Glioma
Authors: Ghiaseddin Ashley , Reardon David , Massey Woody , Mannerino Alex , Lipp Eric S. , Herndon James E. , McSherry Frances , Desjardins Annick , Randazzo Dina , Friedman Henry S. , Peters Katherine B. 
Published: November 2017

Abstract

Lessons Learned
Combination regimen with bevacizumab (BEV) and vorinostat is well tolerated in patients with recurrent glioblastoma. Treatment of recurrent glioblastoma remains challenging as this study and others attempt to improve progression-free survival and overall survival with BEV-containing regimens.

Background
Recurrent glioblastoma (GBM; World Health Organization grade 4) continues to have a very poor prognosis. Bevacizumab (BEV) has been shown to improve progression-free survival (PFS) in recurrent GBM and is approved by the U.S. Food and Drug Administration for the treatment of recurrent GBM. Combination regimens have been explored, and in this phase II nonrandomized trial, we evaluated the efficacy of BEV combined with histone deacetylase inhibitor vorinostat (VOR) in recurrent GBM.

Materials and Methods
In this phase II, single-center, nonrandomized study, subjects with recurrent GBM received BEV 10 mg/kg intravenously (IV) every 2 weeks combined with VOR 400 mg p.o. daily for 7 days on, 7 days off, in a 28-day cycle. The primary endpoint was 6-month PFS (PFS6).

Results
Forty patients with recurrent GBM were enrolled and evaluated. PFS6 was 30.0% (95% confidence interval [CI] 16.8%–44.4%). Median overall survival (OS) was 10.4 months (95% CI 7.6–12.8 months). Overall radiographic response rate was 22.5% based on 9 partial responses. The most common grade 2 and above treatment-related adverse events were lymphopenia (55%), leukopenia (45%), neutropenia (35%), and hypertension (33%). Grade 4 adverse events were leukopenia (3%), neutropenia (3%), sinus bradycardia (3%), and venous thromboembolism (3%). Two deaths occurred in this study, with one due to tumor progression and another possibly related as death not otherwise specified.

Conclusion
Combination treatment of BEV and VOR was well tolerated. This combination therapy for this study population did not improve PFS6 or median OS when compared with BEV monotherapy.
Vanaf die Dekaan / From the Dean
Authors: Smit Nicola 
Published: November 2017

Die Fakulteit Regte is nou halfpad na ŉ honderdjarige. Weens haar ouderdom is sy diep begrond en strek haar takke en vrugte wyd. Ten spyte van haar ouderdom is sy egter steeds speels met baie planne en vol entoesiasme vir die toekoms. Ons is dankbaar dat ons hierdie mylpaal kon bereik, maar tyd is relatief en daar is immers die ou waarheid dat kosbare gedagtes ewig is en nooit oud sal word nie. Daar is talle gedagtes van ons vorige personeelkorpse verewig in joernale en boeke oor die afgelope 50 jaar en hierdie bundel bou daarop voort.The Faculty of Law is halfway in her journey to becoming a centenarian. Her age ensures that she is a well-grounded and well-respected dame with the fruits of her labour stretching far and wide. Yet, despite her age, she is still sprightly and filled with enthusiasm for the future. We are grateful that she could reach this milestone, but time, like so many things, is relative and the ancient truth remains that precious thoughts are everlasting and will never decay, diminish or grow old. The thoughts and ideas of our previous staff members have been immortalised in journals, books and publications during the past 50 years, and this collection builds on this fine tradition.
Cine y pedagogía: aristas de la relación
Authors: Rodríguez Humberto Alexis 
Published: November 2017

En este artículo se analizan las relaciones entre cine, escuela y pedagogía desde la perspectiva de cinco momentos cinematográficos. Se ilustran con estas piezas una serie de interrogantes sobre la alteración de la mirada, que implica la mediación de la cámara cinematográfica (el caso de Blow-Up, de Antonioni); se plantean (con Pizarras y con La clase) algunas preguntas sobre la representación que el cine hace de la escuela y de los docentes y sus funciones; igualmente, se extiende (con Doce monos y, finalmente, desde The Matrix) la mirada a los horizontes de una educación abocada a enfrentar nuevas fuentes de imaginarios.