bluuebunny/crossref_metadata_2025_split huggingface dataset:
Goats are more susceptible to Haemonchus contortus infection than sheep under similar experimental settings
Authors: Risa Desta , Mamo Gezahegne , Waktole Hika , Haile Geremew , Terefe Getachew 
Published: October 2024

AbstractDue to differences in their feeding behavior, sheep and goats are often assumed to respond differently to helminth infections. The present study compared Haemonchus contortus infection profile between sheep and goats under the same experimental setting. Experimental infection was conducted using a randomized block design in four groups of intact sheep (InfSH and ConSH) and goats (InfG, and ConG). Groups InfSH and InfG (N = 7 each) received 10,000L3 of H. contortus whereas the control groups ConSH and ConG (N = 7 each) remained uninfected. Faecal egg counts and PCV were measured from Day 0 to day 56 post infection (PI). On day 56 PI, animals were humanely slaughtered and abomasal contents were recovered to measure worm burden, worm length and in utero egg count. The findings show that: (1) Haemonchus infected animals showed an increase in FEC starting from day 21 PI, (2) progressive reduction in PCV was registered from day 7 PI and continued to the end of the experiment while this remained at pre-infection levels in control groups, (3) FEC was much higher (P < 0.001) and PCV was significantly lower (P < 0.05) in infected goats than in infected sheep, (4) at necropsy, total worm burden with worm establishment rates of 63% and 28.87% were registered respectively for infected goats and sheep with significant difference (P < 0.05), (5) Female worms were significantly longer (P < 0.05) in InfG (22.8(± 1.2) compared to InfSH (20.5 ± 0.67 mm) while (6) Mean worm fecundity was 974.8 ± 239.4 and 1162.5 ± 89.4 respectively for groups InfSH and InfG with no significant difference (P = 0.07), and (7) Parasite traits such as worm burden, FEC and female worm length were well correlated in sheep whereas few such patterns were observed in goats. In conclusion, under the same experimental infection, Arsi-Bale goats are more susceptible to H. contortus infection than Arsi-Bale sheep and hence deserve special attention when they are forced to live on grazing rather than browsing.
Impact of met-haemoglobin and oxidative stress on endothelial function in patients with transfusion dependent β-thalassemia
Authors: Rabie Maha Abubakr Feissal , El Benhawy Sanaa A. , Masoud Inas M. , Arab Amal R. R. , Saleh Sally A. M. 
Published: October 2024

AbstractTransfusion dependent β-thalassemia is a genetic blood disorder characterized by chronic anaemia. Blood transfusion is lifesaving but comes at a cost. Iron overload emerges as a prime culprit as a free radicals damage endothelial cells. Chronic anaemia further disrupts oxygen delivery, exacerbating the oxidative stress. Increased levels of met-haemoglobin and malondialdehyde compromise endothelial function. This research sheds light on the impact of met-haemoglobin and oxidative stress on endothelial function in 50 patients with transfusion dependent β-thalassemia major compared to 50 healthy individuals as control. Blood samples were collected & subjected to CBC, biochemical analysis including creatinine, ferritin, CRP, LDH, and HCV antibodies. Oxidative stress was assessed using met-haemoglobin & malondialdehyde. Endothelial dysfunction was evaluated by endothelial activation and stress index (EASIX). EASIX, met-haemoglobin and malondialdehyde were significantly increased in patients (1.44 ± 0.75, 2.07 ± 0.2, 4.8 ± 0.63; respectively) compared to the control (0.52 ± 0.24,0.88 ± 0.34,0.8 ± 0.34; respectively). Significant strong positive correlation was found between EASIX and met-haemoglobin, malondialdehyde, serum ferritin and CRP (P = 0.00, r = 0.904, P = 0.00, r = 0.948, P = 0.00, r = 0.772, P = 0.00, r = 0.971; respectively. Met-haemoglobin as well as EASIX should be routinely estimated to assess endothelial function especially before the decision of splenectomy. Antioxidant drugs should be supplemented.
Rapid Campimetry in glaucoma – correspondence with standard perimetry and OCT
Authors: Djouoma Nidele , Müller Fabian , Stolle Francie H. , Hoffmann Friedrich , Thieme Hagen , Hoffmann Michael B. , Al-Nosairy Khaldoon O. 
Published: October 2024

AbstractThe Rapid Campimetry (RC), a kinetic visual field test proved to reliably detect visual field defects within the central 10° degrees, the most crucial part for visual acuity and quality of life, affected even at very early stages of glaucoma, within a short measurement epoch, ~ 1 min. This study aims to further investigate RC correspondence with standard tests in glaucoma, namely standard automated perimetry (SAP) and optical coherence tomography (OCT) within 10° of visual field (VF). For this purpose, we included 41 participants, [21 glaucoma (GLA, mean age: 65.9 ± 12.4; 12 preperimetric eyes and 11 with VF defects) and 20 healthy controls (HC; mean age: 65.0 ± 10.3); 20 eyes]. At first, we compared the rate of detection/exclusion of VF defects in RC vs. SAP. Then, for those with VF defects (11 eyes), we investigated the 68-pointwise correspondence of 10 − 2 layout of RC and SAP. For functional and structural (SF) correspondence, pointwise correspondence of RC, SAP vs. OCTmacula [ macular ganglion cell thickness (GCL)] was also performed. Further, we compared sector-based correspondence of RC, SAP vs. OCTmacula accounting for GCL displacement at the fovea as well as sector-based correspondence with OCTdisc [peripapillary retinal nerve fiber layer thickness (pRNFL)]. Agreement estimates were reported along with Cohen Kappa ($$\:\kappa\:$$) statistic. For overall performance, RC and SAP showed 100% agreement ($$\:\kappa\:=1$$) for the exclusion of VF defects (HC and preperimetric GLA) and for detection of VF defects [11 eyes of 9 GLA, ($$\:\kappa\:=1)$$]. Further, RC outperformed SAP in detection of arcuate scotomas, 7 vs. 5, respectively. Pointwise correspondence of VF defects (11 eyes), RC-SAP agreement reached 90% accuracy ($$\:\kappa\:=0.77,\:substantial\:agreement$$). For SF correspondence, RC [SAP] showed 62% [69%] pointwise agreement with OCTmacula, ($$\:\kappa\:=0.10\:\left[0.33\right]$$). For macular sector-based correspondence, SF correspondence improved and reached 83% [83%] agreement, ($$\:\kappa\:=0.57\:\left[0.57\right]$$). For OCTdisc sector-based analysis, SF correspondence was highest, 100% [100%] agreement, ($$\:\kappa\:=1\:\left[1\right]$$). Rapid Campimetry gave reproducible results in comparison to SAP and OCT with high potential as a screening VF method given its short testing duration, ~ 1 min in screening mode, and compatibility with telemedicine technologies upon future optimization and automation.
In situ decorated pd NPs on Triazin-encapsulated Fe3O4/SiO2-NH2 as magnetic catalyst for the synthesis of diaryl ethers and oxidation of sulfides
Authors: Singh Durgesh , Singh Kamini , Sharma Pawan , Jadeja Yashwantsinh , MGM Johar , Singh Priyanka , Kaur Kiranjeet , Atif M. , El-Meligy Mohammed A. , Husseen Beneen 
Published: October 2024

AbstractThis article is devoted to the synthesis of a new magnetic palladium catalyst that has been immobilized on A-TT-Pd coated-magnetic Fe3O4 nanoparticles. Such surface functionalization of magnetic particles is a promising method to bridge the gap between heterogeneous and homogeneous catalysis approaches. The structure, morphology, and physicochemical properties of the particles were characterized through different analytical techniques, including TEM, FT-IR, XRD, SEM, EDS, TGA-DTG, ICP, and VSM techniques. The obtained Fe3O4@SiO2@A-TT-Pd performance can show excellent catalytic activity for the synthesis of diaryl ethers and oxidation of sulfides, and the corresponding products were obtained with high yields. The advantages of this catalyst include a simple test method, green reaction conditions, no use of dangerous solvents, short reaction time, low catalyst loading, and reusability. Also, the nanocatalyst was easily separated from the reaction mixture with the help of a bar magnet and recovered and reused several times without loss of stability and activity.
Selected somatic parameters and body composition as predictors of cardiorespiratory fitness among Polish adolescents aged 11–14
Authors: Marks Karolina , Kopeć Dorota , Lenik Justyna , Lenik Paweł , Dziadek Bartosz 
Published: October 2024

AbstractThe aim of the study was to verify whether selected somatic parameters and components of body composition were significant predictors of cardiorespiratory fitness (CRF) among a potentially healthy Polish population of adolescents aged 11–14 years. The cross-sectional study was conducted on a group of 375 subjects (164 girls, and 211 boys). A 20 m shuttle run test (20 m SRT) was used to assess CRF. The total number of rounds was taken into account. Basic somatic parameters were measured: body mass (BM), body height (BH), waist circumference (WC), hip circumference (HC), body mass index (BMI), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR), and body composition components: body fat percentage (FM%), fat mass (FM kg), total body water (TBW), fat-free mass (FFM). Statistical analyses included basic statistical measures (mean and standard deviation) and Spearman rank correlation coefficient. Multiple linear regression analysis was performed to detect significant predictors of CRF. In each proposed model, the dependent variable was the number of rounds, and the independent variables were selected somatic parameters and components of body composition. More than half (65%) of the subjects had an average or lower level of CRF, and 35% of the population presented a good or above good level of CRF. The study showed a statistically significant negative correlation between BM, FM%, FM kg, HC, WC, BMI, WHR, WHtR and the number of laps in the total sample. The strongest correlation in the group of girls was noted for age (r = 0.34) and in the group of boys for FM% (r = $$-0.52$$

-
0.52

). Each regression model presented proved to be statistically significant, and the significant predictors of CRF in the group of girls were age ($$R^2$$

R
2

= 16%) and FM% ($$R^2$$

R
2

= 6%). In the group of boys, the significant predictors of CRF were WHtR ($$R^2$$

R
2

= 8%) and age ($$R^2$$

R
2

= 2%). Estimating body fat distribution is useful in assessing cardiorespiratory fitness, and this in turn indicates its usefulness in preventive screening of school-aged adolescents.
On the efficiency of paired ranked set sampling for estimating the population mean in the presence of non-response
Authors: Rehman Syed Abdul , Al-Essa Laila A. , Shabbir Javid , Khan Zaheen 
Published: October 2024

AbstractNon-response is a common problem faced by surveyors while conducting surveys; this introduces a potential bias in the estimates of population parameters. One method of dealing with non-response is subsampling of the non-respondents, which increases precision in estimates by increasing the sample size. This study proposes an unbiased mean estimator in the presence of non-response using the Paired Ranked Set Sampling (PRSS) technique. The proposed estimator is based on a suggested strategy for adapting the subsampled units into the initial sample. Variance of the proposed estimator is derived, and conditions are provided for which the proposed estimator performs better than existing estimators. We conduct a simulation study to evaluate the precision of the proposed estimator in comparison with other existing estimators for estimating the population mean. In simulation, we assume populations based on normal distribution, exponential distribution, and real-life data on abalone. Simulation results show that the proposed mean estimator exhibits a higher probability of precisely estimating the finite population mean.
Early ablation leads to better outcome in patients < 55 years with persistent atrial fibrillation
Authors: Erhard Nico , Bahlke Fabian , Neuner Bruno , Popa Miruna , Krafft Hannah , Tunsch-Martinez Alexander , Syväri Jan , Tydecks Madeleine , Abdiu Edison , Telishevska Marta , Lengauer Sarah , Hessling Gabriele , Deisenhofer Isabel , Englert Florian 
Published: October 2024

AbstractThe question of optimal timing for catheter ablation of atrial fibrillation (AF) to achieve best outcomes remains a crucial clinical issue. As AF occurs less frequently in younger patients, data regarding Diagnosis-to-Ablation Time (DAT) is especially limited in patients under the age of 55 years with persistent AF. We therefore analyzed the temporal relationship between initial AF presentation and timing of catheter ablation in this cohort. We conducted a retrospective single-centre study of patients ≤ 55 years with persistent AF who underwent first-time catheter ablation at our center. The cohort was divided into patients that underwent catheter ablation after diagnosis of persistent AF within a DAT of ≤ 12 months and patients with a DAT of > 12 months. A total of 101 patients (median age 51 years; female n = 19 (18.8%)) with persistent AF were included. Ablation was performed within 12 months (“early DAT”) in 51 patients and > 12 months (“late DAT”) in 50 patients. Pulmonary vein isolation was performed using high-power short-duration (HPSD) radiofrequency ablation. Median DAT was 5 months (1–12 months) in the early ablation group and 36 months (13–240 months) in the late ablation group. The median follow-up was 11.3 months (0.03–37.1 months). The rate of any atrial arrhythmia recurrence after a 30-day blanking period was significantly lower in the early DAT group (13/51 patients; 25.5%) as compared to the late DAT group (26/50 patients; 52.0%) (log rank test; p = 0.003). Catheter ablation performed > 12 months after the initial AF diagnosis was an independent predictor for the occurrence of any atrial arrythmia (OR: 2.58; (95%-CI: 1.32–5.07). Early first-time catheter ablation (DAT ≤ 12 months) in patients ≤ 55 years with persistent AF is associated with a significantly lower rate of arrhythmia recurrence.
A single nucleotide substitution introducing premature stop codon within CsTFL1 explains the determinate-2 phenotype in cucumber (Cucumis sativus L.)
Authors: Biernacik Bartosz , Słomnicka Renata , Kaźmińska Karolina , Mużacz Szymon , Bartoszewski Grzegorz 
Published: October 2024

AbstractThe determinate growth habit of plants reduces the number of internodes and shortens the main stem by terminating the shoot apical meristem through a transition to inflorescence. Understanding the genetic basis of this habit can help optimize crop yield and cultivation technology for vegetable breeding. This study aimed to identify the determinate-2 (de-2) gene responsible for the determinate growth habit in the W-sk cucumber line. Termination of the main stem in the W-sk line occurred between 14 and 23 internodes, depending on cultivation conditions. Resequencing of the W-sk genome identified a novel SNP in the cucumber TERMINAL FLOWER1 (CsTFL1) gene, explaining the de-2 phenotype. This was verified with a CAPS-T marker cosegregation with determinate growth in the F2:3 population, and this polymorphism is unique among genotyped indeterminate cucumber cultivars or breeding lines. Crossing the W-sk line with the G421 line with the determinate (de) gene confirmed the allelism of both genes. An SNP in CsTFL1 in the W-sk line introduced a premature stop codon, resulting in the putative deletion of 13 amino acids, possibly causing determinate growth habit. Overall, this study provides insights into the genetic basis of cucumber plant growth architecture and advances in cucumber breeding.
Accelerated ensemble optimization using momentum methods
Authors: Nilsen Mathias M. , Stordal Andreas S. , Lorentzen Rolf J. , Raanes Patrick N. , Eikrem Kjersti S. 
Published: October 2024

AbstractWe investigate the use of various momentum methods in combination with an ensemble approximation of gradients, for accelerated optimization. Although momentum gradient descent methods are popular in machine learning, it is unclear how they perform when applied to time-consuming dynamic problems such as production optimization for petroleum reservoir management. Four different momentum methods are extensively tested on a reservoir test case in one deterministic and one robust setting. The numerical experiments show that momentum strategies yield, on average, a higher net present value with fewer simulations needed.
Transport mechanism of DgoT, a bacterial homolog of SLC17 organic anion transporters
Authors: Dmitrieva Natalia , Gholami Samira , Alleva Claudia , Carloni Paolo , Alfonso-Prieto Mercedes , Fahlke Christoph 
Published: October 2024

AbstractThe solute carrier 17 (SLC17) family contains anion transporters that accumulate neurotransmitters in secretory vesicles, remove carboxylated monosaccharides from lysosomes, or extrude organic anions from the kidneys and liver. We combined classical molecular dynamics simulations, Markov state modeling and hybrid first principles quantum mechanical/classical mechanical (QM/MM) simulations with experimental approaches to describe the transport mechanisms of a model bacterial protein, the d-galactonate transporter DgoT, at atomic resolution. We found that protonation of D46 and E133 precedes galactonate binding and that substrate binding induces closure of the extracellular gate, with the conserved R47 coupling substrate binding to transmembrane helix movement. After isomerization to an inward-facing conformation, deprotonation of E133 and subsequent proton transfer from D46 to E133 opens the intracellular gate and permits galactonate dissociation either in its unprotonated form or after proton transfer from E133. After release of the second proton, apo DgoT returns to the outward-facing conformation. Our results provide a framework to understand how various SLC17 transport functions with distinct transport stoichiometries can be attained through subtle variations in proton and substrate binding/unbinding.
Feature selection and data‐driven model for predicting the remaining useful life of lithium‐ion batteries
Authors: Zhang Yuhao , Han Yunfei , Cai Tao , Xie Jia , Cheng Shijie 
Published: October 2024

AbstractTo ensure long and reliable operation of lithium‐ion battery storage workstations, accurate, fast, and stable lifetime prediction is crucial. However, due to the complex and interrelated ageing mechanisms of Li‐ion batteries, using physical model‐based methods for accurate description is challenging. Therefore, building data‐driven models based on direct measurement data (voltage, current, capacity, etc.) during battery operation may be a more effective approach. This paper employs a time series analysis of discharge capacity/voltage curves to perform feature predication. The goal is to predict the state of health using a short‐term model and the remaining useful life of batteries using a long‐term iterative model. The validity of this method is verified using the open‐source MIT battery dataset. Comparisons with models reported in the literature demonstrate that this method is generalisable and ensures accuracy across a wider range of predictions.
Study on transient electric shock characteristics between human body and metal clothes hanger on residential platform near UHV AC transmission lines
Authors: He Wangling , Zhang Ke , Wan Baoquan , Zhao Jun , Zhang Yinlu , Liu Yunpeng , Zhou Dasen , Zhang Tianyu 
Published: October 2024

AbstractWith the development of ultra‐high‐voltage (UHV) and extra‐high‐voltage transmission lines in China, the transmission lines are gradually approaching the residential areas. The phenomenon of induced electric shock caused by electrostatic induction effect can cause dissatisfaction and complaints from nearby residents. In this paper, a full‐size steel‐framed residential test platform was constructed near a 1000‐kV UHV alternating current (AC) transmission line, the transient shock characteristics of human bodies and metal hangers in different scenarios was investigated, then the relationship between transient shock energy and subjective perception of the human body was discussed. In addition, the shielding effect of shielding wires for transient electric shock situations is analyzed. It was found that the worst‐case scenario occurred when the grounded human body came into contact with the insulated metal clothes hanger, even eliciting a noticeable sensation of pain. In addition, increasing metal shielding wire number has a significant effect on weakening induced electric shocks.
Real‐time reliability evaluation method for IGBT module in MMC based on junction temperature and bond wire failure online monitoring
Authors: Dongye Zhonghao , Zhang Wuyu , Qi Lei , Gu Bowen , Shen Hong , Zhang Xiangyu , Cui Xiang 
Published: October 2024

AbstractThe lack of an MMC reliability evaluation approach that incorporates data on essential components' health monitoring in the already related research prevents reliability from being further improved. Therefore, this article proposes a real‐time reliability evaluation method of the multi‐state IGBT module in MMC through iterative calculation of the Markov chain model. The degradation process of the IGBT module is divided into multiple states based on the monitored bond wire failure, and the failure rate of the IGBT module is updated in real time using the accumulated monitoring data of junction temperature. The proposed method can more accurately reflect the real state of MMC compared with the binary state evaluation method. Besides, a multi‐channel high‐speed data acquisition board is designed to measuring the gate voltage and collector voltage of the IGBT for the health evaluation of IGBT modules in MMC; the typically measured results validate the effectiveness of the data acquisition board.
An optimal parameter design method for cascaded H‐bridge multi‐level converter in wind farm
Authors: Xiao Huagen , Zhang Yongxi 
Published: October 2024

AbstractThe cascaded H‐bridge multi‐level converter is the main topology of high‐voltage and high‐capacity converter in renewable energy power generation, energy storage system and reactive power compensation equipment. The parameter design of cascaded H‐bridge multi‐level converters directly determines the material cost and performance. Taking the output current distortion rate and the ripple voltage of the capacitor of the cascaded H‐bridge multi‐level converter as the constraint conditions, this paper proposes an overall parameter optimal design method of the cascaded H‐bridge multi‐level converter based on the optimization of the total material cost. Finally, the effectiveness of the proposed parameter design method is verified by the simulation result.