bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of advanced thyroid cancer with targeted therapies: ten years of experience
Authors: Viola David , Valerio Laura , Molinaro Eleonora , Agate Laura , Bottici Valeria , Biagini Agnese , Lorusso Loredana , Cappagli Virginia , Pieruzzi Letizia , Giani Carlotta , Sabini Elena , Passannati Paolo , Puleo Luciana , Matrone Antonio , Pontillo-Contillo Benedetta , Battaglia Valentina , Mazzeo Salvatore , Vitti Paolo , Elisei Rossella 
Published: May 2016

AbstractThyroid cancer is rare, but it is the most frequent endocrine malignancy. Its prognosis is generally favorable, especially in cases of well-differentiated thyroid cancers (DTCs), such as papillary and follicular cancers, which have survival rates of approximately 95% at 40 years. However, 15–20% of cases became radioiodine refractory (RAI-R), and until now, no other treatments have been effective. The same problems are found in cases of poorly differentiated (PDTC) and anaplastic (ATC) thyroid cancers and in at least 30% of medullary thyroid cancer (MTC) cases, which are very aggressive and not sensitive to radioiodine. Tyrosine kinase inhibitors (TKIs) represent a new approach to the treatment of advanced cases of RAI-R DTC, MTC, PDTC, and, possibly, ATC. In the past 10 years, several TKIs have been tested for the treatment of advanced, progressive, and RAI-R thyroid tumors, and some of them have been recently approved for use in clinical practice: sorafenib and lenvatinib for DTC and PDTC and vandetanib and cabozantinib for MTC. The objective of this review is to present the current status of the treatment of advanced thyroid cancer with the use of innovative targeted therapies by describing both the benefits and the limits of their use based on the experiences reported so far. A comprehensive analysis and description of the molecular basis of these therapies, as well as new therapeutic perspectives, are reported. Some practical suggestions are given for both the choice of patients to be treated and their management, with particular regard to the potential side effects.
Complex Haploinsufficiency-Based Genetic Analysis of the NDR/Lats Kinase Cbk1 Provides Insight into Its Multiple Functions in Candida albicans
Authors: Saputo Sarah , Norman Kaitlyn L , Murante Thomas , Horton Brooke N , Diaz Jacinto De La Cruz , DiDone Louis , Colquhoun Jennifer , Schroeder Jeremy W , Simmons Lyle A , Kumar Anuj , Krysan Damian J 
Published: May 2016

Abstract
Although the analysis of genetic interactions and networks is a powerful approach to understanding biology, it has not been applied widely to the pathogenic yeast Candida albicans. Here, we describe the use of both screening and directed genetic interaction studies based on complex haploinsufficiency to probe the function of the Regulation of Ace2 and Morphogenesis (RAM) pathway in C. albicans. A library of 5200 Tn7-mutagenized derivatives of a parental strain heterozygous at CBK1, the key kinase in the RAM pathway, was screened for alterations in serum-induced filamentation. Following confirmation of phenotypes and identification of insertion sites by sequencing, a set of 36 unique double heterozygous strains showing complex haploinsufficiency was obtained. In addition to a large set of genes regulated by the RAM transcription factor Ace2, genes related to cell wall biosynthesis, cell cycle, polarity, oxidative stress, and nitrogen utilization were identified. Follow-up analysis led to the first demonstration that the RAM pathway is required for oxidative stress tolerance in a manner related to the two-component-regulated kinase Chk1 and revealed a potential direct connection between the RAM pathway and the essential Mps1 spindle pole-related kinase. In addition, genetic interactions with CDC42-related genes MSB1, a putative scaffold protein, and RGD3, a putative Rho GTPase-activating protein (GAP) were identified. We also provide evidence that Rgd3 is a GAP for Cdc42 and show that its localization and phosphorylation are dependent on Cbk1.
ESTILOS DE VIDA SALUDABLES: UN DERECHO FUNDAMENTAL EN LA VIDA DEL SER HUMANO
Authors: Salas Cabrera Jorge 
Published: May 2016

El propósito del presente estudio fue evidenciar el impacto que tienen algunos estilos de vida enel diario vivir; además, se referencian varios de estos, entre los cuales se citan: el sedentarismo, laalimentación, la práctica de actividad física, el apoyo social y familiar, así como las repercusionesque tienen en la calidad de vida de las personas. Es claro que, como ser humano, el desarrollo en sudiario vivir está direccionado por deberes y derechos que condicionan las forma de convivencia. Apartir de lo anterior, todo ser humano debe gozar del derecho a una mejor calidad de vida, y paraalcanzar dicho objetivo es necesario mantener hábitos de vida saludables que generen mecanismosde protección a las personas ante el desarrollo de enfermedades crónico-degenerativas. Históricamente,se ha comprobado que las personas que mantienen hábitos de vida poco saludables llegan,con el paso del tiempo, a desarrollar enfermedades no solo del tipo hipocinéticas, sino tambiénenfermedades asociadas a problemas de tipo neurológico, como el Alzheimer y el Parkinson. Bajoeste panorama, se pretende en este escrito presentar información clara y concisa acerca de lo querepresentan los estilos de vida en el ser humano y su importancia como un derecho del que puedagozar todo aquel que decida adaptarlos a su diario vivir. AbstractThe purpose of this study was to demonstrate the impact of certain lifestyles in our daily lives, andto reference some of them, among which are a sedentary lifestyle, diet, physical activity, social andfamily support, and the impact they have on people’ quality of life. It is clear that as a human beings,the developments in everyday life are addressed by duties and rights that affect our way of living,hence all individuals should enjoy the right to a better quality of life; to achieve this, it is necessary tomaintain healthy lifestyle habits that create mechanisms to protect people against the development ofchronic degenerative diseases. Historically it has been shown that people who have unhealthy life habits
A pair rajzelemzési technika alkalmazása 8–9 éves gyermekek győzelemmel és vesztéssel kapcsolatos rajzain
Authors: Sándor Mónika , Fülöp Márta , Sebestyén Nóra 
Published: May 2016

A gyermekkori versengés jelensége sokat vizsgált terület, azonban kevés azon kutatások száma, amelyek a versengés kimeneteleinek, a győzelemnek és vesztésnek gyermeki reprezentációját kívánják mélyrehatóan feltérképezni.
Jelen vizsgálat célja a győzelem és a vesztés fogalmának, valamint a két szituációban megjelenített győztes és vesztes viszonyának a feltárása volt kisiskolások képi reprezentációjában, rámutatva esetleges nemi és iskolatípus-beli (magas tanulmányi követelményű és átlagos) különbségekre is. A vizsgálat alapját 30 kisiskolás (átlag életkor: 8,6 év) győzelemmel és vesztéssel kapcsolatos rajza képezte. A 30 győzelem és 30 vesztés rajz elemzése a PAIR módszer (Pictorial Assessment of Interpersonal Relationship, BOMBI, PINTO és CANNONI, 2007) segítségével történt, mely hat szempont (kohézió, távolítás, hasonlóság, érték, érzelmek és konfliktus) mentén vizsgálja az interperszonális kapcsolatokat.
Az eredmények alapján elmondható, hogy a 8–9 éves gyerekek képesek a győztes és a vesztes érzelmi állapotát és a győztes és a vesztes perspektíváját rajzaikban világosan elkülöníteni. A győztes és vesztes, valamint kettőjük kapcsolata másképp reprezentálódik, ha a győzelem a kontextus, mint ha a vesztés. Ez arra utal, hogy a győztes és vesztes interperszonális kapcsolata más érzelmekkel és kapcsolati törekvésekkel jár, attól függően, hogy a győztes vagy a vesztes perspektívájából éli át a gyerek.
A győzelem domináns és kiemelt pozíciót jelent a győztes számára, a győztes gyakrabban lát rá a vesztesre, szélesebb a perspektívája, mint a vesztesnek, és a győztest mind a győzelem mind a vesztés rajzokon szignifikánsan értékesebbnek ábrázolják. A győztes perspektívájából készült rajzokon a győztes értékesebbnek ábrázolódik, a győztes és a vesztes kapcsolata közelebbi, közöttük nagyobb az összetartás, mint a vesztes perspektívájából készült rajzokon. Ezzel összhangban a győzelmet a középpontba helyező ábrázolásokon a vesztes kevésbé elégedetlen, mint a vesztést a középpontba helyezőkön, és a győzelem rajzokon kevesebb konfliktust jelenítenek meg a gyerekek a győztes és a vesztes között, mint a vesztés rajzokon. A kutatás bizonyos nemi és iskolatípus-beli különbségeket is feltárt.
A Case Study of the Mann Deshi Mahila Sahakari Bank (MDMSB): A Model of Financial Capability through Social Entrepreneurship
Authors: Balkawade Minakshi 
Published: May 2016

<p>Economic development in terms of poverty alleviation and gender equity is at the root of all State-run programmes in almost all emerging economies, including India. However although the Indian government has constantly launched commendable poverty alleviation programmes for the rural poor and women, along with financial inclusion initiatives, they have met a lack-lustre success, owing to a top-down approach i.e. either finance sans application (knowledge, skill and ability) or vice-versa. This necessitated institutional capacity building i.e. development in the form of social capital at the rural level by the local people, in addition to financial inclusion programmes. Thus were born rural social entrepreneurs with their unique rural development models, with an aim to generate employment opportunities for alleviating poverty by fostering women entrepreneurship.</p><p><br />This study takes an overview of one such social entrepreneur - Chetna Gala Sinha, who promoted the Mann Deshi Mahila Sahakari Bank (MDMSB), the first ever women’s rural co-operative bank in Maharashtra, which aims at rural women entrepreneurship development through its first of its kind financial capability model.</p>
SWOT Analysis of Purchasing Markets in the Region of Asia
Authors: Shi Yangyan 
Published: May 2016

<p class="ber"><span lang="EN-GB">Due to the financial crisis 2008, many countries have faced the challenges from the economic downwards. There are many economic entities emerging from the region of Asia. Many foreign companies focus on exploring the Asian markets, due to low labor cost, cheap raw materials, and international transportation hub. This paper mainly examines purchasing markets in the region of Asia. Analyzing the economic outlook and business environment reveals the current market situation in the region of Asia. In addition, this paper highlights the key industries for each Asian country, which help international firms understand the features of industries in each country. A summary of popular exports products is also listed. The contribution of this paper is to give a comprehensive understanding overall of purchasing markets in the region of Asia. </span></p>
Outcome after Cementless Total Hip Arthroplasty for Arthritic Hip in Patients with Residual Poliomyelitis: A Case Series
Authors: Cho Yoon J. , Lee Choong H. , Chun Young S. , Rhyu Kee H. 
Published: May 2016

Purpose In this case series, we investigated the outcome of cementless total hip arthroplasty (THA) for advanced hip osteoarthritis in patients with residual poliomyelitis to evaluate its clinical usefulness for these patients. Methods 11 unilateral cementless primary THA were performed to arthritic hips in patients with residual poliomyelitis. 7 were in paralytic and 4 were in nonparalytic limbs. The mean follow-up duration was 79.9 months. Retrospective clinical evaluations with various scores and radiological evaluations were made. Results Harris Hip Score, Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Short-form (SF)-36 physical scales were significantly improved after the surgery. However, UCLA activity score and SF-36 mental scale were not. Because of remaining leg length discrepancies, all but 1 noted a residual limp. In nonparalytic hip, functional acetabular cup inclination during weight bearing significantly increased from installed inclination. Other than 1 case of posterior dislocation, no complications were observed. Conclusions Although the overall result itself is excellent, THA for these patients cannot improve limp, physical activity and mental status. Surgeons should be aware of the change of the inclination of acetabular cup during mobilisation, especially for THA in contralateral hip.
Práticas de responsabilidade social corporativa e gestão de pessoas no contexto brasileiro: uma análise das empresas modelo em sustentabilidade e melhores para trabalhar
Authors: Campos Simone Alves Pacheco de , De Andrade Taís , Estivalete Vania De Fátima Barros , Costa Vivian Flores , Stefanan Aline Armanini 
Published: May 2016

This study aims to analyses the corporate social responsibility (CSR) and human resource management practices of organizations considered model in sustainability and are best places to work. Thus, we carried out a research by analyzing the Guides Exame de Sustentabilidade e Melhores Empresas para Trabalhar, comprising the period from 2006 to 2011. In relation to practices associated to social/cultural dimension of CSR, the results shows the concern with supporting education and local development. In relation to practices related to environmental/ecological dimension of CSR, there was a predominance of practices related to the use of recyclable materials. The human resource management practices prioritized traditional actions, with less concern with social, behavioral and ethical aspects. Even organizations investigated are model in HRM and CRS, were shown gaps related to the interaction of HRM practices with CSR internally.
Construindo alianças estratégicas para a produção na sétima arte: um estudo multicasos em produtoras cinematográficas brasileiras
Authors: Gonçalves Carlos Alberto , Silva Everton Rodrigues , Lopes Daniel Paulino Teixeira 
Published: May 2016

The movie industry is characterized by the ambiguity of being an industrial activity and a symbolic to the national identity. Despite its relevance, there is a literature gap concerning the role of alliances in the national film production. We sought to understand this process through the lens of the industry structure and the resource-based view. This study was qualitative in nature on the basis of a multiple case study approach and semi-structured interviews. The findings showed that, due to the majors’ oligopolistic domain, the national industry inherited the North American pattern for revenue-sharing among participants in the production chain. However, the United States market structure is based in both vertical integration and strong ties between the movie industry and the television industry. Analyzing the Brazilian movie industry, government resignation from investing in production, reduced film lifecycles, and few projects funded privately (via incentive laws), competition between productions is fierce. We found not only that alliances are essential to the functioning of the industry (resource complementarity), but also that producers are strongly dependent to other elements in the movie value system – particularly due to power asymmetries created by the industry structure. Complementarity and dependency go hand in hand.
The Power Brokers
Authors: Lambert Jeremiah D. 
Published: May 2016

How the interplay between government regulation and the private sector has shaped the electric industry, from its nineteenth-century origins to twenty-first-century market restructuring.
For more than a century, the interplay between private, investor-owned electric utilities and government regulators has shaped the electric power industry in the United States. Provision of an essential service to largely dependent consumers invited government oversight and ever more sophisticated market intervention. The industry has sought to manage, co-opt, and profit from government regulation. In The Power Brokers, Jeremiah Lambert maps this complex interaction from the late nineteenth century to the present day.
Lambert's narrative focuses on seven important industry players: Samuel Insull, the principal industry architect and prime mover; David Lilienthal, chairman of the Tennessee Valley Authority (TVA), who waged a desperate battle for market share; Don Hodel, who presided over the Bonneville Power Administration (BPA) in its failed attempt to launch a multi-plant nuclear power program; Paul Joskow, the MIT economics professor who foresaw a restructured and competitive electric power industry; Enron's Ken Lay, master of political influence and market-rigging; Amory Lovins, a pioneer proponent of sustainable power; and Jim Rogers, head of Duke Energy, a giant coal-fired utility threatened by decarbonization. Lambert tells how Insull built an empire in a regulatory vacuum, and how the government entered the electricity marketplace by making cheap hydropower available through the TVA. He describes the failed overreach of the BPA, the rise of competitive electricity markets, Enron's market manipulation, Lovins's radical vision of a decentralized industry powered by renewables, and Rogers's remarkable effort to influence cap-and-trade legislation. Lambert shows how the power industry has sought to use regulatory change to preserve or secure market dominance and how rogue players have gamed imperfectly restructured electricity markets. Integrating regulation and competition in this industry has proven a difficult experiment.
Osteopathic Manipulative Treatment Technique Scores on the COMLEX-USA Level 2-PE: An Analysis of the Skills Assessed
Authors: Smith Larissa L. , Xu Wei , Sandella Jeanne M. , Dowling Dennis J. 
Published: May 2016

Abstract

Context: The National Board of Osteopathic Medical Examiners uses the Osteopathic Manipulative Treatment (OMT) Global Rating Tool to score candidate performance in OMT during standardized patient encounters. To the authors’ knowledge, no validity research has been published on the underlying constructs measured by this instrument to date.

Objective: To evaluate whether the OMT Global Rating Tool measures 1 holistic skill or multiple skill sets.

Methods: Structural equation models were fit to data from first-time test-takers who took the Comprehensive Osteopathic Medical Licensing Examination-USA Level 2-Performance Evaluation (COMLEX-USA Level 2-PE) between July 7, 2014, and April 30, 2015. Two theoretical models were evaluated: a model that posited a single underlying skill set, and a model that posited 2 related but distinct skill sets.

Results: The 1-factor and 2-factor models were fit to data from 4673 third- and fourth-year osteopathic medical students. Fit statistics indicated that the data were best fit by a model representing 2 factors: pre– and post–OMT technique assessment and OMT technique (r=0.47).

Conclusion: The OMT Global Rating Tool seems to measure 2 distinct but related skills. Although the results of this study are applicable to broad populations and cannot be used to provide skill-specific subscores, it might be helpful to remediation efforts to target pre– and post–OMT technique assessments and OMT techniques as distinct areas for intervention.
Reducing operation voltages by introducing a low-k switching layer in indium–tin-oxide-based resistance random access memory
Authors: Jin Fu-Yuan , Chang Kuan-Chang , Chang Ting-Chang , Tsai Tsung-Ming , Pan Chih-Hung , Lin Chih-Yang , Chen Po-Hsun , Chen Min-Chen , Huang Hui-Chun , Lo Ikai , Zheng Jin-Cheng , Sze Simon M. 
Published: May 2016

Abstract
In this letter, we inserted a low dielectric constant (low-k) or high dielectric constant (high-k) material as a switching layer in indium–tin-oxide-based resistive random-access memory. After measuring the two samples, we found that the low-k material device has very low operating voltages (−80 and 110 mV for SET and RESET operations, respectively). Current fitting results were then used with the COMSOL software package to simulate electric field distribution in the layers. After combining the electrical measurement results with simulations, a conduction model was proposed to explain resistance switching behaviors in the two structures.
An Advantageous Role of Spectral Doppler Sonography in the Evaluation of Thyroid Dysfunction During the Postpartum Period
Authors: Gaberšček Simona , Osolnik Jasna , Zaletel Katja , Pirnat Edvard , Hojker Sergej 
Published: May 2016

ObjectivesTo evaluate the diagnostic value of spectral Doppler sonography in women with thyroid dysfunction during the first postpartum year.MethodsThis prospective observational clinical study included 83 consecutive untreated women: 32 with hyperthyroid postpartum thyroiditis, 32 with hypothyroid postpartum thyroiditis, and 19 with Graves disease, which first appeared within 12 months after delivery. Thyrotropin, free thyroid hormones, thyroid peroxidase antibodies, thyroglobulin antibodies, and thyrotropin receptor antibodies were measured. With a 7.5‐MHz linear transducer, we measured the thyroid volume and peak systolic velocity (PSV) at the level of intrathyroid arteries.ResultsHyperthyroid postpartum thyroiditis appeared significantly earlier (mean ± SD, 4.4 ± 1.9 months after delivery) than hypothyroid postpartum thyroiditis (6.5 ± 2.1 months) and Graves disease (7.2 ± 2.7 months; P< .001). The thyroid volume in hyperthyroid postpartum thyroiditis (9.7 ± 6.3 mL) was significantly lower than in hypothyroid postpartum thyroiditis (14.7 ± 10.2 mL; P = .030) and Graves disease (19.4 ± 10.2 mL; P< .001). The PSV in hyperthyroid postpartum thyroiditis (9.4 ± 3.4 cm/s) was significantly lower than in hypothyroid postpartum thyroiditis (14.4 ± 3.9 cm/s; P < .001) and Graves disease (19.8 ± 7.0 cm/s; P < .001). With a cutoff level of 15 cm/s, the sensitivity and specificity of the PSV as a predictor of the correct diagnosis in hyperthyroid postpartum women were 94.7% and 96.8%, respectively. A multinomial logistic regression revealed PSV and the time after delivery at which the disorders presented as independent predictors of the differentiation between hyperthyroid postpartum thyroiditis and Graves disease (P = .003; P = .022).ConclusionsSpectral Doppler sonography was shown to be a useful and accurate method for thyroid dysfunction evaluation during the postpartum period.
Assessing the professional competencies of correctional executives' and senior‐level leaders'
Authors: Harper D.S. 
Published: May 2016

BackgroundThis non‐experimental, quantitative study, examines and validates the National Institute of Corrections' executive and senior‐level leadership competencies and predetermined experiences that should lead to identifying the right correctional leadership development. From the solicitation of correctional executives' and senior‐level leaders' own perceptions.MethodsCorrectional Executives (n = 90) completed a researcher designed measure of leaders perceptions of utilization of NIC competencies and experiences.ResultsOn‐the‐job training and progressive job assignment (serving in a role prior to appointment to a long term or permanent assignment) emerged as favorable ways for developing correctional leadership competencies. Additionally, the results of this study provided evidence supporting some highly predictive dependent variables as beneficial for first time executives in corrections and for effective correctional executive leadership.ConclusionsThe results of the study does not support separating leadership profiles for correctional executives and senior‐level leaders. Study showed that leaders agreed on certain competencies when combining leadership experiences. Finally the biological characteristic ethnicities and organizational size identified as predictable factors for the utilization competencies.
ChemInform Abstract: IR Spectra of the NO‐ 3 Anion in NaClO4, Na2SO4, NaClO3, and NaIO3 Host Structures.
Authors: HAJEK B. , MUCK A. , SMRCKOVA O. 
Published: May 2016

AbstractThe observed site symmetries of the planar NO3‐ anion (own symmetry D3h) in the four title host structures are identical with the symmetries (C2v, C3, and Cs) of the ClO4‐, ClO3‐, and IO3‐ anions in NaClO4, NaClO3, and NaIO3, respectively.