bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Convective Drying and Far-Infrared Radiation on the Physical Properties and Microstructure of Yacón Chips (Smallanthus sonchifolius)
Authors: Baldeón Edwin O. , Bracamonte-Herrera Álvaro , Soto-Torres Andrés , Salas-Valerio Walter F. , Vidaurre-Ruiz Julio Mauricio 
Published: September 2024

Convective drying is widely used in the food industry due to its simplicity and versatility, as it allows for better temperature control and heat distribution, which is essential for maintaining product quality. However, this method can be slower compared to infrared drying. The aim of this research was to evaluate the effect of convective and infrared drying on the physical properties and microstructure of yacón chips. An infrared dryer and a convection dryer were used to this effect, setting temperatures of 60, 70, and 80 °C for both methods. The color and texture properties, as well as the microstructure, changed with the increase in temperature. The greatest color variation in the yacón samples was reported by infrared drying at a temperature of 80 ° C. Regarding texture, there were no differences between the two methods. The microstructure of the yacón samples dried by hot air exhibited more significant cell damage, especially at 60 °C, in comparison with infrared drying, which showed a more microporous and compact structure. The results indicate that the method used impacted shrinkage: infrared drying produced a higher level of shrinkage when compared to convective drying. It is important to note that this is a significant physical change that can adversely affect the quality of dehydrated food. Infrared drying produced greater rehydration in comparison with convective drying. Similarly, improved rehydration was observed at a temperature of 70 ºC. In conclusion, the infrared drying method, coupled with appropriate drying conditions, constitutes a good alternative for drying yacón chips.
From passion to knowledge
Authors: Kovács Dániel Attila 
Published: September 2024

AbstractIn this paper, I aim to situate the practical agency of the sage in an overall picture of the development of the Plotinian moral agent. This development can be seen as a gradual transition from external to internal principles of action guidance which endow the agent with autonomy and coherence in her practical actions. The transition from external to internal principles corresponds to a changing relationship between the agent's telos and particular actions. Non-virtuous agents aim at the attainment of an object of desire, while the civically virtuous person aims to perform virtuous actions irrespectively of the achievement of particular objects of desire. Finally, the telos of the sage is the contemplation of forms and she acts practically as a consequence and external activity of having achieved her goal. The analysis of Plotinus' theory of moral development shows that the sage's inward turn and detachment from external circumstances do not involve inactivity in the practical sphere but figure as a necessary condition of her making an active contribution to the order of the sensible world through her actions as opposed to passively responding to external circumstances.
“An Era More than Bleak”
Authors: Péteri Lóránt 
Published: September 2024

AbstractFerenc Farkas, a remarkable twentieth-century Hungarian composer, was one of the most influential professors of composition throughout the history of the Liszt Academy of Music, Budapest. A less known chapter of his life is his involvement in the ethnicist and anti-Semitic political movements of Hungary, during the late 1930s and early 1940s. In 1940, he was among three musicians who elaborated a proposal to establish, in line with the rise of corporatism, a Hungarian Music Chamber. One of the main aims of the new organization would have been a total exclusion of Jewish musicians from all branches of Hungarian musical culture. The Chamber was never actually founded. In 1941, Farkas left Budapest for the Transylvanian city Kolozsvár (Cluj), where he was appointed professor of composition at the Conservatory. One of his first students was György Ligeti, a native Transylvanian, born into a Hungarian family suffering under the anti-Semitic legislation of the Hungarian state. As Ligeti recollected, Farkas “wanted to teach me everything he had learned from his teacher Ottorino Respighi.” Based on archival sources, this study offers new insights into the personal and professional connection between Ligeti and Farkas during the 1940s, and also follows Farkas's post-war path from relative isolation and marginalization to the elite of state socialist music culture.
Core stability exercise for the impact of weightlifting and deadlifting on herniated nucleus pulposus (HNP): a systematic review
Authors: Hartatik Ni Made Ayu Sri , Wardhana Dewa Putu Wisnu , Dharma Bagus Diva Indra 
Published: September 2024

Background: Herniated nucleus pulposus or disc herniation is a serious medical condition, the common cause of sciatic pain, and the most common indication for spine surgery. People doing athletic sports, especially weightlifting and deadlifting, may face significant acute and overuse spinal injuries that can cause HNP. Core stability exercise (CSE) improves athletes' sports performance and can prevent injury. This systematic review aims to determine the impact of core stability exercises on weightlifting and deadlifting on herniated nucleus pulposus.
Method: According to PRISMA recommendations, a systematic review using an online database was carried out. The inclusion criteria set includes studies regarding the impact of core stability exercise on deadlifting and weightlifting to prevent HNP, using adult samples>18 years old and providing the type of CSE exercise. In contrast, the exclusion criteria were studied not available in full text and not available in Bahasa or English. Study quality assessments were done using a checklist for the Joanna Briggs Institute.
Result: Ten studies are included in this systematic review, consisting of six randomized controlled trials, two review articles, one case-control study, and one prospective cohort study. The CSE effectively improves the endurance, strength, mobility, and dynamic balance of core muscles, especially spinal muscles, which can prevent back injury, especially for weightlifters and dead lifters. Core stability exercises should be incorporated into athletes' training programs to improve sports performance and reduce the risk of back injury, especially HNP.
Conclusion: The CSE effectively improves the endurance, strength, mobility, and dynamic balance of core muscle, especially spinal muscle, which can prevent back injury in athletes, especially weightlifters and dead lifters.
Long-term assessment of functional outcome in operated cases of Hirschsprung disease
Authors: Poerwosusanta Hery , Willyanto Nathan Aditya 
Published: September 2024

Background: Hirschsprung disease (HD) is a rare congenital anomaly (1 in 5000 live births) characterized by varying levels of aganglionosis. The evolution of surgical options and outcomes for the successful management of HD has been driven by the aspiration of pediatric surgeons. Hirschsprung's disease postoperative results of pull-through procedure could be influenced by surgical and pathological proficiency and the quality of perioperative care. Controversies persist as to which technique offers the best outcome. The absence of incontinence and constipation remains the most important marker of a good outcome.
Methods: Medical records of HD children who underwent temporary colostomy procedures were analyzed retrospectively from July 2017 to June 2021. Risk factors were evaluated to determine the outcome of HD procedures.
Results: Ninety-two HD patients were included. Based on the univariate analysis, most patients in the study (58.7%) were between the ages of 2 and 12 months. The study population predominantly consisted of males (68.5%) who had low vegetable intake (65.2%) and occasionally exhibited stool stains (66.3%), but their stool consistency was mainly normal (47.8%). Further examination through bivariate analysis revealed a significant negative correlation between stool stains and SOAVE (name of the condition). Similar findings were observed for stool consistency, indicating a significant correlation. Consequently, both variables were subjected to multivariate analysis. The multivariate analysis demonstrated a significant association between stool consistency and SOAVE among patients aged 2-12 months (p=0.000, OR =2.044E-7) and those aged 1-5 years (p=0.000, OR =2.044E-7). An odds ratio (OR) value of less than 1 implies that individuals with normal stool consistency have a lower likelihood of experiencing SOAVE at a young age.
Conclusions: This study showed that children with HD correlated with low daily vegetable intake. Normal feces were associated with higher SOAVE ages and a lower possibility of experiencing SOAVE at a young age.
Terapi thrombopoietin receptor agonist pada pasien immune thrombocytopenia dengan infeksi COVID-19: sebuah laporan kasus
Authors: Permana I Gede Komang Aditya , Rena Renny Anggreni 
Published: September 2024

Background: Coronavirus disease 2019 (COVID-19) is a serious health problem in many parts of the world. COVID-19 may trigger a new presentation of Immune Thrombocytopenia (ITP) or may cause relapse in patients with chronic ITP. Treatment of ITP in COVID-19 patients has the risk of worsening the condition of COVID-19 itself.
Case presentation: A 32-year-old male with a history of chronic Immune Thrombocytopenia (ITP) was confirmed with COVID-19. The condition of ITP is controlled with low-dose steroids, presents with very low platelets, and does not respond to previous treatment; it was later discovered that the patient was infected with COVID-19. COVID-19 is known to aggravate thrombocytopenia in patients with ITP and can lead to new ITP conditions. Recent guidelines state that intravenous immunoglobulin (IvIg) is the first choice in ITP patients who have COVID-19 infection, and thrombopoietin receptor agonist (TPO-RA) was another alternative treatment, in this case, the patient received platelet transfusion therapy and TPO-RA, reported that the patient's platelets were well controlled with the use of TPO-RA and COVID-19 infection also improved with the treatment.
Conclusion: Swift diagnosis is needed to improve the quality of life of patients and minimize the occurrence of potential complications caused by COVID-19 in chronic ITP patients.

Latar Belakang: Coronavirus disease 2019 (COVID-19) merupakan masalah kesehatan yang serius di berbagai belahan dunia dan Organisasi Kesehatan Dunia (WHO) telah menetapkan COVID-19 sebagai pandemi. COVID-19 diketahui menyebabkan gejala pernafasan dengan manifestasi ringan hingga berat dan melibatkan berbagai sistem tubuh seperti hematologi, neurologi, dan sistem kekebalan tubuh.
Presentasi kasus: Seorang laki-laki berusia 32 tahun dengan riwayat Immune Thrombocytopenia (ITP) kronis terkonfirmasi mengidap COVID-19. Kondisi ITP dikendalikan dengan steroid dosis rendah dan datang dengan trombosit yang sangat rendah serta tidak merespons pengobatan sebelumnya, kemudian diketahui bahwa pasien tersebut terinfeksi COVID-19. COVID-19 diketahui memperburuk trombositopenia pada pasien ITP dan dapat menyebabkan kondisi ITP baru. Pedoman terbaru menyatakan bahwa imunoglobulin intravena (IvIg) merupakan pilihan pertama pada pasien ITP yang mengalami infeksi COVID-19, dan agonis reseptor trombopoietin (TPO-RA) merupakan pengobatan alternatif lain, dalam hal ini pasien mendapat terapi transfusi trombosit dan TPO-RA. Setelah terapi dilaporkan bahwa trombosit pasien terkontrol dengan baik dengan penggunaan TPO-RA dan infeksi COVID-19 juga membaik dengan pengobatan.
Kesimpulan: Diagnosis yang cepat diperlukan untuk meningkatkan kualitas hidup pasien dan meminimalisir terjadinya potensi komplikasi akibat COVID-19 pada pasien ITP kronis.
Uji aktivitas antibakteri ekstrak etanol daun pegagan (Centella asiatica) terhadap bakteri Streptococcus pneumoniae secara in vitro
Authors: Purba Rizky , Hendrayana Made Agus , Budayanti Ni Nyoman Sri , Fatmawati Ni Nengah Dwi 
Published: September 2024

Background: The gotu kola plant (Centella asiatica) is one of the herbal ingredients used throughout the world. This plant contains triterpenoids and saponins which have broad therapeutic functions. Streptococcus pneumoniae has become a global problem that causeing community acquired pneumonia the most in the world. Our study investigate further the antibacterial activity of ethanol extract of Centella asiatica leaves to inhibit Streptococcus pneumoniae bacteria.
Methods: The Kirby-Bauer method was used to test the antibacterial activity of gotu kola (Centella asiatica) extract in this study. This is done by measuring the diameter of the inhibition zone and its standard deviation.
Results: In the positive control group of Vancomycin 30 µg, the diameter of the inhibition zone was found to be 26.7 mm, 27.15 mm and 28.05 mm. At concentrations of 25%, 50% and 75% of gotu kola leaf (Centella asiatica) ethanol extract, no antibacterial activity was found. Meanwhile, inhibition zone diameters of 8.3 mm, 8.4 mm, and 8.1 mm were found in the ethanol extract of gotu kola leaves (Centella asiatica) with a concentration of 100%.
Conclusion: Based on the results obtained, the concentration of 100% ethanol extract of gotu kola leaves (Centella asiatica) has antimicrobial activity but is unable to inhibit the growth of Streptococcus pneumoniae bacteria.

Latar Belakang: Tanaman pegagan (Centella asiatica) merupakan salah satu bahan herbal yang digunakan di seluruh dunia. Tanaman ini memiliki kandungan utama triterpenoid dan saponin yang berfungsi sebagai terapeutiknya yang luas. Streptococcus pneumoniae adalah bakteri yang secara historis menjadi patogen paling umum yang menyebabkan pneumonia komunitas di seluruh dunia. Penelitian mengevaluasi lebih lanjut terkait aktivitas antibakteri ekstrak etanol daun pegagan terhadap bakteri Streptococcus pneumoniae.
Metode: Metode Kirby-Bauer digunakan untuk pengujian aktivitas antibakteri ekstrak pegagan (Centella asiatica) pada penelitian ini. Hal ini dilakukan dengan mengukur diameter zona hambat dan standar deviasinya.
Hasil: Pada kelompok kontrol positif Vancomycin 30 µg, ditemukan diameter zona hambat sebesar 26,7 mm, 27,15 mm, dan 28,05 mm. Pada konsentrasi ekstrak etanol daun pegagan 25%, 50%, dan 75% tidak ditemukan aktivitas antibakteri. Sedangkan, diameter zona hambat sebesar 8,3 mm, 8,4 mm, dan 8,1 mm ditemukan pada ekstrak etanol daun pegagan (Centella asiatica) konsentrasi 100%.
Kesimpulan: Penelitian ini menunjukkan bahwa konsentrasi ekstrak etanol daun pegagan (Centella asiatica) 100% mampu menunjukan aktivitas antimikroba tetapi tidak dapat menghambat pertumbuhan bakteri Streptococcus pneumoniae.
Prevalensi polimorfisme gen reseptor vitamin D FokI Rs2228570 pada penderita kusta tipe multibasiler
Authors: Rusyati Luh Made Mas , Krisnaputri Nandya Putu , Karmila I Gusti Ayu Agung Dwi 
Published: September 2024

Introduction: Leprosy is still a health problem in Indonesia. Vitamin D receptors are known to affect leprosy. Polymorphism of the VDR gene can lead to deregulation of vitamin D. The study aimed to evaluate the prevalence of polymorphism of the vitamin D receptor gene FokI rs2228570 in patients with multibacillary type leprosy.
Methods: This study was a cross-sectional study with a purposive sampling method. Patients were enrolled on an outpatient basis between October - December 2023. A total of 27 patients were selected from inclusion and exclusion criteria. Gene amplification was done by using PCR and sequencing procedures. The data was analyzed using SPSS ver. 25, and a p-value ≤ 0.05 was considered significant.
Results: Based on the results of gene sequencing, it was found that the genotype VDR FokI rs2228570 is most Ff, with 13 patients (48.14%), followed by ff and FF genotypes with 8 patients (29.62%) and 6 patients (22.22%).
Conclusion: Based on research results, the prevalence of VDR FokI rs2228570 genotype polymorphism is the most commonly found variant.

Pendahuluan: Kusta masih menjadi permasalahan kesehatan yang terjadi di Indonesia. Reseptor vitamin D diketahui berpengaruh terhadap kusta. Polimorfisme dari gen VDR dapat menyebabkan deregulasi dari vitamin D. Penelitian ini bertujuan untuk mengevaluasi prevalensi polimorfisme gen reseptor vitamin D FokI rs2228570 pada pasien kusta tipe multibasiler.
Metode: Studi ini adalah studi dengan desain obervasional retrospektif dengan metode purposive sampling. Pasien merupakan pasien sudah sedang dalam terapi kusta yang dirawat di RSUP Prof. Dr. I.G.N.G. Ngoerah antara bulan Oktober - Desember 2023. Total 27 pasien dipilih berdasarkan kriteria inklusi dan eksklusi. Amplifikasi gen dilakukan menggunakan prosedur PCR dan sekuensing. Data dianalisis menggunakan SPSS ver. 25, dan nilai p ≤ 0,05 dianggap signifikan.
Hasil: Berdasarkan hasil sekuensing gen, didapatkan bahwa genotipe gen VDR FokI rs2228570 terbanyak adalah genotipe Ff, yakni sebanyak 13 pasien (48,14%), diikuti dengan genotipe ff dan FF masing-masing sebanyak 8 pasien (29,62%) dan 6 pasien (22,22%).
Simpulan: Berdasarkan hasil penelitian, prevalensi polimorfisme gen VDR FokI rs2228570 genotipe heterozigot Ff merupakan varian yang paling banyak ditemukan.
Prevalensi keberadaan gen pslA penyandi biofilm pada isolat klinis Pseudomonas aeruginosa di RSUP Prof. Dr. I G.N.G. Ngoerah periode Juli 2022 - Juni 2023
Authors: Jonathan Viriya , Darwinata Agus Eka , Pinatih Komang Januartha Putra , Tarini Ni Made Adi 
Published: September 2024

Backgrounds: Pseudomonas aeruginosa can form a biofilm in less than 24 hours that is resistant to antibiotics. The pslA gene is exopolysaccharides involved in biofilm formation. Biofilm formed by pslA gene can increase opportunity for acquired resistance mechanisms to occur due to gene transfer between bacteria in the biofilm. This study purpose is to determine the prevalence of pslA gene in MDR and non-MDR P. aeruginosa clinical isolates at Prof. Dr. I.G.N.G. Ngoerah for period July 2022 - June 2023.
Methods: This research is qualitative descriptive study to determine the presence of pslA gene which detected using PCR method. Samples were taken using cross-sectional technique, available clinical isolates for period July 2022 - June 2023 at RSUP Prof. Dr. I.G.N.G. Ngoerah, with identification test VITEK-2 Compact and probability level ≥90%. Obtained data were analyzed descriptively by grouping based on research variables in the form of frequency distribution table.
Results: pslA gene is detected in 37 (88,09%) P. aeruginosa isolates, with 19 (90,47%) among them in MDR isolates, and 18 (85,71%) in non-MDR isolates.
Conclusion: pslA gene is found in MDR and Non-MDR P. aeruginosa isolates.

Latar Belakang: Pseudomonas aeruginosa membentuk biofilm kurang dari 24 jam yang resistan antibiotik. Gen pslA merupakan eksopolisakarida yang terlibat dalam pembentukan biofilm. Dengan adanya biofilm yang terbentuk oleh gen pslA dapat meningkatkan kesempatan terjadinya acquired resistance mechanisms akibat transfer gen antarbakteri dalam biofilm. Penelitian ini bertujuan mencari prevalensi gen pslA pada isolat klinis P. aeruginosa MDR dan non-MDR di RSUP Prof. Dr. I.G.N.G. Ngoerah Periode Juli 2022 - Juni 2023.
Metode: Penelitian adalah deskriptif kualitatif untuk mengetahui keberadaan gen pslA yang terdeteksi menggunakan metode PCR. Sampel penelitian diambil dengan teknik cross-sectional, yaitu isolat klinis yang tersedia selama periode Juli 2022 - Juni 2023 di Laboratorium Mikrobiologi RSUP Prof. Dr. I.G.N.G. Ngoerah, dengan tes identifikasi VITEK-2 Compact dan tingkat probabilitas identifikasi bakteri ≥90%. Data yang didapatkan dianalisis secara deskriptif dengan dikelompokkan berdasarkan variabel penelitian dalam bentuk tabel distribusi frekuensi.
Hasil: Terdeteksi gen pslA pada 37 (88,09%) isolat P. aeruginosa, dengan 19 (90,47%) diantaranya isolat MDR dan 18 (85,71%) pada isolat non-MDR.
Kesimpulan: Bakteri P. aeruginosa terdeteksi pada isolat klinis dari pasien di RSUP Prof. Dr. I.G.N.G. Ngoerah. Gen pslA ditemukan pada isolat P. aeruginosa MDR dan non-MDR.
Risk factor of progression of diabetic retinopathy after cataract surgery: a systematic review and meta-analysis
Authors: Saraswati Putu Putri Titamia , Nyoman Yuni Suryani Dharmaputri P  , Suryathi Ni Made Ari , Andayani Ari 
Published: September 2024

Background: Several researchers have looked into the connection between cataract surgery and the progression of diabetic retinopathy (DR) in various studies. However, the element that places a patient at risk for the advancement of diabetic retinopathy following cataract surgery is still unknown. The primary goal of this meta-analysis is to conduct a comprehensive review of the existing research discussing the factors connected to the progression of diabetic retinopathy after cataract surgery.
Methods: A literature search in scientific literature databases, including Pubmed, ScienceDirect, and Cochrane Library, was conducted. Review Manager 5.4 (Cochrane Collaboration, Oxford, UK) measured and analyzed the risk factor's role in the progression of DR after cataract surgery. A significance value below 0.05 was determined statistically significant.
Results: This review included 657 people from eight different studies. It discovered a significant impact of various parameters on the evolution of diabetic retinopathy after cataract surgery. Serum HbA1c levels (with a mean difference of 1.16; p<0.00), diabetes duration (with a mean difference of 1.89; p=0.02), age at cataract surgery (with a mean difference of -1.72; p=0.01), and insulin treatment (with an odds ratio of 3.74; p<0.00) all demonstrated significant associations with diabetic retinopathy progression after cataract surgery.
Conclusion: Our meta-analysis found that blood HbA1c level, diabetes duration, age at cataract surgery, and insulin treatment were all significant risk variables for postoperative DR progression.
Relationship between hypospadias type, age at surgery, and inflammatory index with hope score in hypospadias patients
Authors: Hery Poerwasusanta  , Adiatma Riz Sanfebrian , Meitria Syahadatina Noor  , Agung Ary Wibowo  , Hendra Sutapa  , Gusasi Sulandri , Edi Hartoyo  
Published: September 2024

Introduction: Hypospadias is a congenital anomaly of the anterior urethral opening of the penis, curved penis, and penile foreskin posterior to the penis. Hypospadias occurs in 0.4-8.2 out of 1000 babies. The aim of hypospadias surgery is to restructure the glans into a cone and straighten the penis into a slit calibre with a meatus at the top. The purpose of this research is to assess the association between the HOPE score in Hypospadias patients in Banjarmasin and the kind of hypospadias, age at surgery, NLR, and PLR.
Methods: This research used a cross-sectional design and observational analysis. The sampling used in the study was all population members with a hypospadias diagnosis according to specific criteria and through sample approval. The analysis was univariate and bivariate with the Chi-Square and Mann-Whitney tests. The significant p-value was <0.05.
Results: Thirty-eight patients diagnosed with hypospadias showed a relationship between hypospadias type and HOPE score with a p-value of 0.001, age at the surgery with a HOPE score p-value of 0.267, NLR with a HOPE score p-value of 0.896, and PLR with HOPE score p-value of 0.089.
Conclusion: The variable associated with the HOPE score in patients with hypospadias is the type of hypospadias.