bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain functional connectivity abnormalities in attention‐deficit hyperactivity disorder
Authors: Silberstein Richard B. , Pipingas Andrew , Farrow Maree , Levy Florence , Stough Con K. , Camfield David A. 
Published: September 2016

AbstractIntroductionRecent evidence suggests that attention‐deficit hyperactivity disorder (ADHD) is associated with brain functional connectivity (FC) abnormalities.MethodsIn this study, we use steady‐state visually evoked potential event‐related partial coherence as a measure of brain FC to examine functional connectivity differences between a typically developing (TD) group of 25 boys and an age/IQ‐matched group of 42 drug naive boys newly diagnosed with ADHD (ADHD group). Functional connectivity was estimated while both groups performed a low‐demand reference task and the A‐X version of the continuous performance task (CPT A‐X).ResultsWhile the TD and ADHD groups exhibited similar prefrontal FC increases prior to the appearance of the target in the reference task, these groups demonstrated significant FC differences in the interval preceding the appearance of the target in the CPT A‐X task. Specifically, the ADHD group exhibited robust prefrontal and parieto‐frontal FC increases that were not apparent in the TD group.ConclusionThe FC differences observed in the ADHD group are discussed in the context of inadequate suppression of cortical networks that may interfere with task performance.
Copper Complexes of New Redox‐Active 4,5‐Bisguanidino‐Substituted Benzodioxole Ligands: Control of the Electronic Structure by Counter‐Ligands, Solvent, and Temperature
Authors: Schrempp David Fridolin , Kaifer Elisabeth , Wadepohl Hubert , Himmel Hans‐Jörg 
Published: September 2016

AbstractHerein, we analyze the possibility of controlling the electronic structure of mononuclear copper complexes featuring new redox‐active 4,5‐bisguanidino‐substituted benzodioxole ligands. The nature of the guanidino groups, the anionic counter‐ligands, the applied solvent (polarity), and the temperature are the parameters that decide if a CuII complex with neutral ligand unit or a CuI complex with radical monocationic ligand unit is the adequate description. Under special conditions, a temperature‐dependent equilibrium of the two valence tautomeric forms (CuII/neutral ligand and CuI/radical monocationic ligand) is achieved. Removal of a ligand‐centered electron from a paramagnetic CuII complex with a neutral ligand unit leads to a diamagnetic CuI complex with a dicationic ligand unit through a redox‐induced electron‐transfer (RIET) process.
Luminescent Dinuclear Bis‐Cyclometalated Gold(III) Alkynyls and Their Solvent‐Dependent Morphologies through Supramolecular Self‐Assembly
Authors: Yim King‐Chin , Au Vonika Ka‐Man , Hung Ling‐Ling , Wong Keith Man‐Chung , Yam Vivian Wing‐Wah 
Published: September 2016

AbstractA series of luminescent bis‐cyclometalated gold(III) complexes containing bridging alkynyl ligands of different natures has been synthesised and characterised. The photophysical properties of the complexes have been investigated through electronic absorption spectroscopy and emission studies. The vibronic emission bands are found to originate from the triplet intraligand (IL) π–π* excited states of the bis‐cyclometalating ligands with some mixing of 3IL π–π* character of the alkynyl ligands. The electrochemical study of a nonsymmetric dinuclear complex shows two successive reduction processes originating from the reductions of the two different cyclometalating ligands. The complexes are found to undergo supramolecular self‐assembly processes driven by π–π stacking and hydrophobic/hydrophilic interactions to give honeycomb nanostructures, as revealed from the SEM images. Solvent‐dependent morphological transformations have also been observed, which have been studied by SEM and 1H NMR spectroscopy.
Synthesis of Triptycene‐Substituted Azapentacene and Azahexacene Derivatives
Authors: Biegger Philipp , Tverskoy Olena , Rominger Frank , Bunz Uwe H. F. 
Published: September 2016

AbstractWe describe the synthesis and characterization of novel iptycene‐substituted azaacenes by using either a classic condensation route (diamine plus ortho‐quinone) and/or a Pd‐catalyzed coupling of an aromatic diamine with an aromatic dihalide. The attachment of an iptycene unit leads to a significant blueshift (15 nm) in the UV/Vis spectra of these azaacenes. The iptycene unit stabilizes a hexaazahexacene with a λmax abs of 833 nm. By employing 5,6‐diamino(benzothiadiazole) as a synthon for tetraaminobenzene, we could prepare the symmetrical bis‐triptycene‐substituted tetraazapentacene in high yields.
ChemInform Abstract: Crystal Structure of LaSr3Fe3O8 (OH)2·xH2O.
Authors: Oeygarden Vegar , Fjellvaag Helmer , Soerby Magnus H. , Sjaastad Anja O. 
Published: September 2016

AbstractThe hydrated Ruddlesden—Popper phase of title is prepared by hydrothermal treatment of LaSr3Fe3O9 with degassed H2O (or D2O) in a separate compartment (autoclave, 50 °C, 12 h).
ChemInform Abstract: A new One‐dimensional Strontium Vanadium Tellurite, Sr7V4Te12O41.
Authors: Kim Sun Woo , Emge Thomas J. , Greenblatt Martha 
Published: September 2016

AbstractSingle crystals of Sr7V4Te12O41 are obtained from melts of equimolar amounts of SrTeO4 and VO2 (evacuated quartz tubes, 973 K, 1 d).
ChemInform Abstract: Yb9+CuMg4‐ (x = 0.034): A ϰ‐Phase Formed by Lanthanoids.
Authors: De Negri Serena , Romaka Vitaliy , Solokha Pavlo , Saccone Adriana , Giester Gerald , Michor Herwig , Rogl Peter F. 
Published: September 2016

AbstractThe crystal structures of Yb2Cu1.83Mg (I) and Yb9.034CuMg3.966 (II) are determined by powder and single crystal XRD, respectively.
ChemInform Abstract: Zn2NF and Related Analogues of ZnO.
Authors: Lingampalli Srinivasa Rao , Manjunath Krishnappa , Shenoy Sandhya , Waghmare Umesh V. , Rao C. N. R. 
Published: September 2016

AbstractVariation of the band gap of ZnO is achieved by progressive substitution of O by N and F.
ChemInform Abstract: Synthesis and Catalytic Asymmetric Applications of Quinazolinol Ligands.
Authors: Karakaya Idris , Karabuga Semistan , Mart Mehmet , Altundas Ramazan , Ulukanli Sabri 
Published: September 2016

AbstractA range of synthesized chiral quinazolinol ligands is investigated for the catalytic activity in both the asymmetric phenylation of aryl aldehydes and the asymmetric epoxidation of chalcones.
ChemInform Abstract: Lactamization of sp2 C—H Bonds with CO2: Transition‐Metal‐Free and Redox‐Neutral.
Authors: Zhang Zhen , Liao Li‐Li , Yan Si‐Shun , Wang Lei , He Yun‐Qi , Ye Jian‐Heng , Li Jing , Zhi Yong‐Gang , Yu Da‐Gang 
Published: September 2016

AbstractThe use of CO2 as convenient carbonyl source and excess (3 to 4.5 eq.) NaOtBu as base allows the efficient cyclization of variously substituted 2‐alkyl substituted anilines to 2‐quinolinones.
ChemInform Abstract: Palladium Complexes of Anionic N‐Heterocyclic Carbenes Derived from Sydnones in Catalysis.
Authors: Lucke Ana‐Luiza , Wiechmann Sascha , Freese Tyll , Guan Zong , Schmidt Andreas 
Published: September 2016

AbstractA Pd‐complex derived from 4‐bromo‐3‐phenylsydnone proves to be active as catalyst in Suzuki—Miyaura reactions.
ChemInform Abstract: Eco‐Friendly Synthesis of Benzoxazepine and Malonamide Derivatives in Aqueous Media.
Authors: Babazadeh Mirzaagha , Hosseinzadeh‐Khanmiri Rahim , Zakhireh Solmaz 
Published: September 2016

AbstractThe catalytic system, H5PW10V2O40/MCM‐48, can be easily recovered by simple filtration and reused up to four times without significant loss of activity.
ChemInform Abstract: Polystyrene Supported N‐Phenylpiperazine—Cu(II) Complex: An Efficient and Reusable Catalyst for KA2‐Coupling Reactions under Solvent‐Free Conditions.
Authors: Perumgani Pullaiah C. , Keesara Srinivas , Parvathaneni Saiprathima , Mandapati Mohan Rao 
Published: September 2016

AbstractA polymer supported N‐phenylpiperazine—Cu(II) complex efficiently catalyzes the multicomponent reaction of a ketone (I), an alkyne and an amine furnishing propargylamines in good to excellent yields.
ChemInform Abstract: Generation of the Methoxycarbonyl Radical by Visible‐Light Photoredox Catalysis and Its Conjugate Addition with Electron‐Deficient Olefins
Authors: Slutskyy Yuriy , Overman Larry E. 
Published: September 2016

Abstractfor the direct and regioselective construction of a 1,4‐dicarbonyl structural motif
ChemInform Abstract: Ligand‐Free, Cu‐ and Fe‐Catalyzed Selective Ring‐Opening Arylations of Benzoxazoles with Aryl Iodides.
Authors: He Yue , Mao Jincheng , Rong Guangwei , Yan Hong , Zhang Guoqi 
Published: September 2016

AbstractThe copper‐catalyzed reaction of benzoxazoles with aryl iodides leads to 2‐(diarylamino)phenols, whilst the iron‐catalyzed reaction affords 2‐(arylamino)phenols.
ChemInform Abstract: Highly Selective Copper‐Catalyzed Oxidation of Benzyl Alcohols to Aromatic Aldehydes in Water at Room Temperature.
Authors: Wu Jianglong , Liu Yan , Ma Xiaowei , Liu Ping , Gu Chengzhi , Dai Bin 
Published: September 2016

AbstractThe catalytic system exhibits a wide substrate scope with high functional group tolerance and recyclability for two runs.
ChemInform Abstract: Regioselective Construction of Diverse and Multifunctionalized 2‐Hydroxybenzophenones for Sun Protection by Indium(III)‐Catalyzed Benzannulation.
Authors: Cai Hongyun , Xia Likai , Lee Yong Rok 
Published: September 2016

AbstractThe title compounds are prepared by the highly regioselective indium(III)‐catalyzed benzannulation reaction between benzopyran derivatives and β‐enaminoesters or ‐enamino ketones.
ChemInform Abstract: Organocatalytic Asymmetric Synthesis of trans‐Configured Trispirooxindoles Through a Cascade Michael‐Cyclization Reaction.
Authors: Wu Chaoling , Jing Linhai , Qin Dabin , Yin Mingxing , He Qiuzuo 
Published: September 2016

AbstractA novel stereoselective Michael cyclization reaction of cyclic methyleneindolinones and 3‐isothiocyanatooxindoles is presented furnishing chiral trispirooxindoles in good yield and enantioselectivities.
ChemInform Abstract: Sulfamic Acid as Energy Efficient Catalyst for Synthesis of Flurophores, 1‐H‐Spiro[isoindoline‐1,2′‐quinazoline]‐3,4′(3′H)‐diones.
Authors: Mane Mansing M. , Pore Dattaprasad M. 
Published: September 2016

AbstractThe title spiro compounds are prepared by sulfamic acid‐catalyzed reaction of anthranilamide with cyclic carbonyl compounds.
ChemInform Abstract: Iron‐Mediated Oxidative C—H Coupling of Arenes and Alkenes Directed by Sulfur: An Expedient Route to Dihydrobenzofurans.
Authors: Cavanagh Craig W. , Aukland Miles H. , Laurent Quentin , Hennessy Alan , Procter David J. 
Published: September 2016

AbstractThe sulfur‐directed oxidative C—H ortho‐coupling of arenes with alkenes gives rise to chlorides (III) in moderate yields.
ChemInform Abstract: Synthesis, Biochemistry, and Computational Studies of Brominated Thienyl Chalcones: A New Class of Reversible MAO‐B Inhibitors.
Authors: Mathew Bijo , Haridas Abitha , Ucar Guelberk , Baysal Ipek , Joy Monu , Mathew Githa E. , Lakshmanan Baskar , Jayaprakash Venkatesan 
Published: September 2016

AbstractThe title chalcones are prepared and tested for their inhibitory activities towards human monoamine oxidase (hMAO).
ChemInform Abstract: Base‐Catalyzed Controllable Reaction of 3‐Ylideneoxindoles with O‐Boc Hydroxycarbamates for the Synthesis of Amidoacrylates and Spiroaziridine Oxindoles.
Authors: Liu Yi‐Yin , Duan Shu‐Wen , Zhang Rui , Liu Yun‐Hang , Chen Jia‐Rong , Xiao Wen‐Jing 
Published: September 2016

AbstractThe direction of the reaction of 3‐ylideneoxindole with O‐Boc hydroxycarbamate depends on the catalyst used leading to amidoacrylates, bispirooxindole, or spiroaziridine.
ChemInform Abstract: The Synthesis and Biological Evaluation of Unsymmetrical 2,2‐Di(1H‐indol‐3‐yl)‐N‐phenylacetamide Derivatives.
Authors: Li Ren‐Jun , Zhou Yan , Zheng Yang , Hai Li , Wu Yong 
Published: September 2016

AbstractThe title compounds are prepared by regioselective Friedel—Crafts alkylation of alcohols (I) and (IV) with various indoles.
ChemInform Abstract: I2—DMSO Promoted Metal Free Oxidative Cyclization for the Synthesis of Substituted Indoles and Pyrroles.
Authors: Ramakrishnam Raju Addada , Venkata Reddy Regalla , Mallikarjuna Rao Vajja , Venkata Naresh Vema , Venkateswara Rao Anna 
Published: September 2016

AbstractA mild and operationally simple method is presented for the cyclization reactions of 2‐aminoacetophenones or enamines with phenylalkynes to form indoles and pyrroles, respectively.
ChemInform Abstract: Ru‐Catalyzed Highly Site‐Selective C—H Bond Arylation of 9‐(Pyrimidin‐2‐yl)‐9H‐carbazole.
Authors: Reddy K. Harsha Vardhan , Kumar R. Uday , Reddy V. Prakash , Satish G. , Nanubolu Jagadeesh Babu , Nageswar Y. V. D. 
Published: September 2016

AbstractThe ortho‐arylation of the title compounds is carried out using aryl boronic acids to afford the target compounds in moderate to good yields and with good functional group tolerance.
ChemInform Abstract: Facile Access to 3,7‐Dialkyltetrahydro‐1H,5H‐[1,2,4]triazolo[1,2‐a] [1,2,4]triazole‐1,5‐dithiones.
Authors: Saeed Aamer , Channar Pervaiz Ali , Larik Fayaz Ali , Floerke Ulrich 
Published: September 2016

AbstractThe title triazole derivatives are prepared from thiosemicarbazide and aliphatic aldehydes via formation and intramoleculare cyclization of thiosemicarbazone in good yields.
ChemInform Abstract: Facile Synthesis of 3‐Amino‐5‐aryl‐1,2,4‐oxadiazoles via PIDA‐Mediated Intramolecular Oxidative Cyclization.
Authors: Lu Kuan , Duan Liancheng , Xu Boxuan , Yin Weile , Wu Di , Zhao Yanfang , Gong Ping 
Published: September 2016

AbstractThe title oxadiazoles are prepared by intramolecular cyclization of aromatic N‐acylguanidines using PhI(OAc)2 as oxidant in moderate to good yields.
ChemInform Abstract: Cyclization of 4‐Phenoxy‐2‐coumarins and 2‐Pyrones via a Double C—H Activation.
Authors: Mackey Katrina , Pardo Leticia M. , Prendergast Aisling M. , Nolan Marie‐T. , Bateman Lorraine M. , McGlacken Gerard P. 
Published: September 2016

AbstractThe aryl‐heteroaryl coupling‐method avoids the need of activating groups.
ChemInform Abstract: Synthesis of 2‐Substituted Furo[2,3‐b]‐ and Furo[3,2‐c]quinolines via Heterogeneous Palladium‐Catalyzed Heteroannulation.
Authors: Park Hee Jung , Yang Ok‐Kyung , Park Young Chul , Yum Eul Kgun 
Published: September 2016

AbstractTitle compounds are synthesized starting from o‐halohydroxyquinolines [(I) or (IV), resp.] and terminal alkynes (II) with Pd(OAc)2 supported by nanosized pore carbon balls as catalyst.
ChemInform Abstract: Tandem Allylic Alcohol Isomerization/Oxo‐Michael Addition Reaction Promoted by Re2O7.
Authors: Lai Yisheng , et al.  
Published: September 2016

AbstractA regioselective and stereoselective isomerization of cyclohexadienone‐tethered allylic alcohols followed by diastereoselective ring‐closure via oxa‐Michael addition leads to bicyclic enones.
ChemInform Abstract: Nano‐Ferrite Supported Glutathione as a Reusable Nano‐Organocatalyst for the Synthesis of Phthalazine‐Trione and Dione Derivatives under Solvent‐Free Conditions.
Authors: Dam Binoyargha , Saha Mithu , Jamatia Ramen , Pal Amarta Kumar 
Published: September 2016

AbstractThe catalyst can be recycled by an external magnet and reused in five more consecutive runs without significant loss of activity.
ChemInform Abstract: Magnetically Recyclable Copper Modified GO/Fe3O4 Catalyst for Efficient Synthesis of Quinazolinones.
Authors: Kong Lu‐Lu , Fan Li‐Yan 
Published: September 2016

AbstractBioactive quinazolinones (III) are effectively synthesized by condensation of iodobenzamides (I) with amino acids (II) in good yields using magnetically recyclable and reusable Fe3O4/graphene oxide‐CuI as catalyst.
ChemInform Abstract: Dipolar Dyes with a Pyrrolo[2,3‐b]quinoxaline Skeleton Containing a Cyano Group and a Bridged Tertiary Amino Group: Synthesis, Solvatofluorochromism, and Bioimaging.
Authors: Lukasiewicz Lukasz G. , Deperasinska Irena , Poronik Yevgen M. , Jun Yong Woong , Banasiewicz Marzena , Kozankiewicz Boleslaw , Ahn Kyo Han , Gryko Daniel T. 
Published: September 2016

AbstractDipolar dye (IV) is successfully used in the two‐photon imaging of mouse organ tissues.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Hydrosilylation of Styrene and Its Derivatives with Chiral Phosphoramidite Ligands Containing Chiral Ferrocenyl Amine.
Authors: Park Hyun‐Sub , Kim Min Young , Ahn Hyo Jin , Han Jin Wook 
Published: September 2016

AbstractAsymmetric hydrosilylation of styrene and its derivatives (I) is accomplished using a palladium catalyst with the title ligand.
ChemInform Abstract: Two New Diterpenoids from the Endophytic Fungus Trichoderma sp. Xy24 Isolated from Mangrove Plant Xylocarpus granatum.
Authors: Dai Jun‐Gui , et al.  
Published: September 2016

AbstractTwo harziane diterpenoids, named (9R,10R)‐dihydro‐harzianone (I) and harzianelactone (II) are isolated from the endophytic fungus Trichoderma sp.
ChemInform Abstract: Carbon Nanotubes as Electrically Active Nanoreactors for Multi‐Step Inorganic Synthesis: Sequential Transformations of Molecules to Nanoclusters and Nanoclusters to Nanoribbons.
Authors: Botos Akos , Biskupek Johannes , Chamberlain Thomas W. , Rance Graham A. , Stoppiello Craig T. , Sloan Jeremy , Liu Zheng , Suenaga Kazutomo , Kaiser Ute , Khlobystov Andrei N. 
Published: September 2016

AbstractConfinement in the nanoscale cavities of single‐walled carbon nanotubes (SWNTs) is used for multistep inorganic synthesis within the same nanotube.
ChemInform Abstract: Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid‐State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs
Authors: Baghel Shrawan , Cathcart Helen , O'Reilly Niall J. 
Published: September 2016

AbstractReview: 217 refs.
Microwave‐Assisted Syntheses of Benzimidazole‐Containing Selenadiazole Derivatives That Induce Cell‐Cycle Arrest and Apoptosis in Human Breast Cancer Cells by Activation of the ROS/AKT Pathway
Authors: Liang Yuanwei , Zhou Yangliang , Deng Shulin , Chen Tianfeng 
Published: September 2016

AbstractThe use of selenium‐containing heterocyclic compounds as potent cancer chemopreventive and chemotherapeutic agents has been well documented by a large number of clinical studies. In this study we developed a new approach to synthesize four benzimidazole‐containing selenadiazole derivatives (BSeDs). The method uses a combination of peptide coupling reagents and microwave irradiation. This strategy features milder reaction conditions, higher yields, and shorter reaction times. The synthetic BSeDs were identified as potent antiproliferative agents against the human MCF‐7 and MDA‐MB‐231 breast cancer cell lines. Compounds 1 b (5‐(6‐methyl‐1H‐benzo[d]imidazol‐2‐yl)benzo[c][1,2,5]selenadiazole), 1 c (5‐(6‐chloro‐1H‐benzo[d]imidazol‐2‐yl)benzo[c][1,2,5]selenadiazole), and 1 d (5‐(6‐bromo‐1H‐benzo[d]imidazol‐2‐yl)benzo[c][1,2,5]selenadiazole) were found to show greater cytotoxicity against the triple‐negative breast cancer cell line MDA‐MB‐231 than MCF‐7, and to exhibit dose‐dependent inhibition of cell migration, in which a significant decrease in the zone of cell monolayer wound closure was observed relative to untreated controls. Our results demonstrate that BSeDs can cause cell‐cycle arrest and apoptosis in MDA‐MB‐231 cells by inducing DNA damage, inhibiting protein kinase B (AKT), and activating mitogen‐activated protein kinase (MAPK) family members through the overproduction of reactive oxygen species (ROS). Taken together, the results of this study provide a facile microwave‐assisted strategy for the synthesis of selenium‐containing organic compounds that exhibit a high level of anticancer efficacy.
Clinical presentation and outcomes for adult ependymoma patients
Authors: Acquaye Alvina A. , Vera Elizabeth , Gilbert Mark R. , Armstrong Terri S. 
Published: September 2016

BACKGROUNDOutcomes projects can be a catalyst for determining disease‐ and treatment‐related consequences for patients with rare tumors. The Adult Ependymoma Outcomes (AEO) survey uses self‐reported experience to evaluate how this tumor affects patient groups throughout the illness trajectory.METHODSPatients completed the AEO survey via a Web‐based portal. The survey included questions on treatment, tumor recurrence, and current health status; the MD Anderson Symptom Inventory Brain Tumor and Spine Tumor modules; and the Medical Outcomes Study 36‐Item Short Form Health Survey (SF‐36).RESULTSThe sample included 264 participants (57% female) with a median age of 46 years (range, 18‐77 years). Radiation treatment was commonly used for patients who had brain involvement (χ2(1) = 20.7; P < .001), underwent a partial resection (43%; χ2(3) = 15.4; P < .001), or had a grade 3 tumor (41%; χ2(2) = 18.8; P < .001). Recurrence occurred in a small group (29%), with grade 1 tumor patients 2.6 times more likely and grade 3 tumor patients 2.5 times more likely to experience recurrence than those with grade 2 tumors. Spine tumor patients had a higher symptom burden (mean, 2.8; scale, 0‐10) than brain tumor patients (t(247) = −4.0), and they reported more moderate to severe symptoms (rating ≥ 5; 29%) than their counterparts (18%). Within the physical health portion of the SF‐36, spine tumor patients reported worse health with respect to bodily pain (t(249) = 6.8; P < .001), physical functioning (t(252) = 4.1; P < .001), and vitality (t(202.2) = 3.0; P < .003).CONCLUSIONSThese results demonstrate the feasibility of implementing outcomes projects that report on the clinical and demographic characteristics of a rare patient population, and they underscore the importance of outcomes data in understanding disease‐related issues. Cancer 2017;123:494–501. © 2016 American Cancer Society.
Vibrational Response of Methylammonium Lead Iodide: From Cation Dynamics to Phonon–Phonon Interactions
Authors: Ivanovska Tanja , Quarti Claudio , Grancini Giulia , Petrozza Annamaria , De Angelis Filippo , Milani Alberto , Ruani Giampiero 
Published: September 2016

AbstractThe dynamic evolution of the vibrational interactions in the prototypical CH3NH3PbI3 was studied through a comprehensive experimental and theoretical investigation with a focus on the interactions between the organic cations and the inorganic cage. To date, no clear picture has emerged on the critical and fundamental interactions between the two perovskite components, despite the relevance of phonons to the electronic properties of several classes of perovskites. For the first time, we have monitored the IR and nonresonant Raman response in the broad frequency range 30–3400 cm−1 and in the temperature interval 80–360 K. Strong changes in the energies of different vibrational modes with temperature are observed and examined in the framework of phonon–phonon interactions considering a significant anharmonic contribution to the phonon relaxation process. The vibrational relaxation of the bending modes and their reorientation activation energies identify that such mechanisms are governed by medium‐to‐strong hydrogen bonds in the orthorhombic phase; however, any ferroelectric ordering in the orthorhombic phase is governed mostly by dipole interactions. These changes imply that charge localization mechanisms play a primary role, and our study enriches the fundamental knowledge of phonon interactions and charge transport in CH3NH3PbI3 for the further development of optoelectronic applications.