bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-Life Use of 3 Direct-Acting Antiviral Regimen in a Large Cohort of Patients with Genotype-1b HCV Compensated Cirrhosis
Authors: Gheorghe Liana , Iacob Speranta , Curescu Manuela , Brisc Ciprian , Cijevschi Cristina , Caruntu Florin , Stanciu Carol , Simionov Iulia , Sporea Ioan , Gheorghe Cristian , Iacob Razvan , Arama Victoria , Sirli Roxana , Trifan Anca 
Published: September 2017

Background & Aims: Ombitasvir/Paritaprevir/ritonavir/Dasabuvir (OBV/PTV/r+DSV) is one of the elective direct-acting antivirals (DAAs) recommended by international guidelines and the only one covered by the National Insurance System in Romania until November 2016. Our aim was to present the first prospective Romanian cohort evaluating the effectiveness and safety in clinical practice of this 3DAA combination in patients with HCV genotype-1b Child A liver cirrhosis.Methods: 681 patients received OBV/PTV/r+DSV+RBV for 12 weeks and were assessed clinically and biologically at baseline, week 4, 8, 12 (end of treatment, EOT), and 12 weeks after therapy (sustained viral response, SVR).Results: Per protocol, EOT virological response was 99.8% and SVR12 rate was 99.4%. Adverse events were present in 36.4% of patients. Permanent discontinuation of 3DAA regimen due to side effects was reported in 11 patients (1.6%). In 47.6% (185/389) of patients, Transient Elastography values were >20kPa (defined as clinically significant portal hypertension, CSPH) at baseline. Independent variables associated with CSPH were: baseline cholesterol level (p=0.003), platelet count <120,000/mm³ (p=0.02), MELD score (p=0.01).Liver stiffness measurement has significantly improved between baseline (26.6±12.7kPa) and SVR12 (21.6±11.8kPa) (p<0.0001). The same was true for APRI score (2.66±0.15 at baseline vs 0.85±0.02 at SVR12, p<0.0001) and FIB4 score (5.53±0.28 vs 3.24±0.08, p<0.0001), but not for Lok score (0.57±0.01 vs 0.63±0.01, p<0.0001).Conclusions: We report a high efficacy of the 3DAA regimen in a homogeneous compensated HCV genotype-1b liver cirrhosis population, in a real-life setting. Noninvasive fibrosis scores significantly improved at SVR12.Abbreviations: AE: adverse effect; AFP: alpha feto-protein; CSPH: clinically significant portal hypertension; DAA: direct-acting antiviral; EOT: end of treatment; GT: genotype; HCV: hepatitis C virus; HCC: hepatocellular carcinoma; LSM: liver stiffness measurement; MELD: Model of end stage liver disease; NHIA: National Health Insurance Agency; OBV/PTV/r+DSV: Ombitasvir/Paritaprevir/ritonavir/Dasabuvir; RBV: ribavirin; SAE: serious adverse effect; SVR: sustained viral response; TE: transient elastography.
Association of microRNA Polymorphisms with the Risk of Gastric Cancer in a Romanian Population
Authors: Rogoveanu Ion , Burada Florin , Cucu Mihai Gabriel , Vere Cristin Constantin , Ioana Mihai , Cîmpeanu Raluca Alexandra 
Published: September 2017

Background & Aims: MicroRNAs (miRNAs) play an important role in the occurrence and progression of human cancers, including gastric cancer. Our hospital-based case-control study aimed to investigate whether four commonly studied single nucleotide polymorphisms (SNPs) have effects on susceptibility to gastric cancer in a Romanian population.Method: We genotyped the miR-27a rs895819, miR-146a rs2910164, miR-196a2 rs11614913 and miR-499 rs3746444 SNPs by real-time PCR using predesignated TaqMan assays in 430 individuals (142 gastric cancer patients and 288 age and gender matched cancer-free controls). The associations between the investigated miRNA SNPs and gastric cancer risk were assessed by odds ratio (OR) with 95% confidence interval (CI) using logistic regression analysis.Results: A higher frequency of the miR-27a rs895819 CC genotype (OR 1.98, 95% CI: 1.05-3.73, p=0.036) was found in the patients with gastric cancer compared with the controls. Similar results were observed in a recessive model, the CC genotype was correlated with gastric cancer susceptibility (OR 1.95, 95% CI: 1.07-3.55, p=0.032). In the stratified analysis, the association between miR-27a rs895819 SNP and gastric cancer risk was limited to noncardia (OR 2.08, 95% CI: 1.10-3.94, p=0.027) and intestinal (OR 2.27, 95% CI: 1.05-4.92, p=0.042) subgroups. However, after Bonferroni correction, all associations described above lost statistical significance. No correlation was observed for the remaining SNPs and risk of gastric cancer in any genetic model studied.Conclusion: This study showed no association of the investigated miRNA SNPs with the risk of gastric cancer in a Romanian population.Key words: – – – .Abbreviations: GC: gastric cancer; miRNA: microRNA; SNP: single nucleotide polymorphism.
António Feliciano de Castilho, cronista de um século tão destruidor como criador
Authors: Da Cruz Eduardo 
Published: September 2017

António Feliciano de Castilho (1800-1875), reconhecido como poeta, também teve importante atuação no meio jornalístico. Como redator da Revista Universal Lisbonense entre janeiro de 1842 e junho de 1845, ele transformou o projeto editorial familiar num periódico de sucesso, vendido e assinado em todo Portugal e também no Brasil. Além de divulgação de “conhecimentos úteis” e de novas composições literárias, sua revista possuía uma seção de notícias. Nesse espaço, Castilho transformava os relatos dos casos que recebia em crônicas que deixam transparecer seu olhar sobre a sociedade que se transformava em meados do século XIX. Aqui apresentamos alguns dos principais temas e o estilo de construção de suas crônicas.********************************************************************Hora de tirar o espartilho – Women’s issues in the short storiesof Lygia Fagundes TellesAbstract: This paper considers how womens’ issues are presented in Lygia Fagundes Telles’ short stories, evaluating narrative procedures and thematic choices, such as wickedness, dependence, conservatism, emancipation, loneliness, vanity or decrepitude. This study analyses the originality and modernity of Telles’ prose, noting the cautious distance of her vision of the feminine condition from any contemporary trends or labeling. Finally, the paper also aims to study the portrayal of women by Lygia Fagundes Telles. This simplies careful examination of how women occupy the role of the self, or subject, and to what degree Telles’ omens’ characters are individualized figures, facing different conflicts, in a variety of social, familial and affective situations.Keywords: short stories; Lygia Fagundes Telles; feminine condition.
A construção da memória da Guerra Colonial em Os cus de Judas, de Lobo Antunes
Authors: Rommel Leonardo Von Pfeil , Sparemberger Alfeu 
Published: September 2017

O presente artigo analisa o romance Os cus de Judas, de autoria do escritor português António Lobo Antunes quanto à sua particularidade em estabelecer a construção de uma memória coletiva sobre a Guerra Colonial. Segundo romance do autor, publicado em 1979 em um contexto pós-colonial apenas quatro anos após a Revolução dos Cravos, a narrativa remete à abordagem da exploração da experiência do autor durante sua participação na Guerra Colonial, em Angola, no início da década de 70. Após a Revolução dos Cravos, em abril de 1974, a sociedade portuguesa tenta apagar o passado traumático ligado à guerra e ao Estado Novo a fim de iniciar um movimento de superação de seu passado problemático e aproximar-se da Europa. A produção ficcional apresenta-se como possibilidade de interpretação da dinâmica política e social existente na construção de um novo Portugal após a Guerra Colonial, a Revolução dos Cravos e a descolonização dos territórios ultramarinos. A literatura assume um papel de destaque no Portugal pós-colonial, pois almeja a construção de uma memória coletiva sobre os últimos capítulos do império português.********************************************************************The construction of the Colonial War memory in Os cus de Judas, of Lobo AntunesAbstract: The present article analyzes the novel Os cus de Judas, written by the portuguese writter António Lobo Antunes for their particularity to estabilish the construction of a collective memory about the Colonial War. Second novel of the author published in 1979 in a post-colonial context, just four years after the Carnation Revolution, the narrative refer to approach the exploration of the author’s experience during his participation in the Colonial War in Angola, in the early 1970. After the Carnation Revolution in April 1974, the portuguese society tries to erase the traumatic past linked to the war and the Estado Novo to start a movement of overcoming his troubled past and move closer to Europe. The fictional production is presented as a possible interpretation of the dynamics political and social context in building a new Portugal after the Colonial War, the Carnation Revolution and decolonization of overseas territories. The literature plays an important role in Portugal post-colonial since aims to build a collective memory of the last chapter of the portuguese empire.Keywords: Os cus de Judas; Colonial War; Memory; Post-colonialism
Mia Couto: viajante e afinador de identidades
Authors: Ribeiro Orquidea Maria Moreira , Moreira Fernando Alberto Torres 
Published: September 2017

A identidade cultural moçambicana forja-se pela força do diálogo e da articulação funcional de diferentes identidades. Neste particular, a obra de Mia Couto destaca-se pelo modo único como congrega a riqueza desse mecanismo, afirmando-se como um interlocutor original no processo de construção da identidade nacional para o qual concorrem diversos elementos identitários que formam a especificidade moçambicana no conjunto da africanidade. Viajante do tempo, Mia Couto faz a história (e a identidade) moçambicana pela soma de um enorme conjunto de estórias, marca de um conhecimento ancestral que se revela necessário para a construção de um novo paradigma identitário – uma identidade que se constrói no compromisso entre o passado e o presente – que o autor vai afinando em cada nova obra porque se reconhece como “mulato de existências” que anseia pela esperança do futuro.********************************************************************Mia Couto: traveler and tuner of identitiesAbstract: Mozambique's cultural identity is forged by the force of dialogue and functional articulation of different identities. In this regard, Mia Couto’s work is distinguished by the unique way he brings together the wealth of this mechanism, asserting itself as an original party in the national identity building process to which many identity elements contribute to form the Mozambican specificity in set of Africanness. Time traveler, Mia Couto makes Mozambican history (and identity) summing up a huge set of stories, marks of an ancestral knowledge that proves necessary for the construction of a new identity paradigm – an identity that is built on a compromise between past and present – that the author tunes in each new work because he is recognized as "mulatto of existences" that yearns for future hope.Keywords: Mozambique; Mia Couto; Identity; Tradition; Hybridity
Temperature Dependence of Primary Species G(values) Formed from Radiolysis of Water by Interaction of Tritium β-Particles
Authors: Butarbutar Sofia Loren , Sriyono Sriyono , Sunaryo Geni Rina 
Published: September 2017

TEMPERATURE DEPENDENCE OF PRIMARY SPECIES G(VALUES) FORMED FROM RADIOLYSIS OF WATER BY INTERACTION OF TRITIUM β-PARTICLES. G(values) are important to understand the effect of radiolysis of Nuclear Power Plant (NPP) cooling water. Since direct measurements are difficult, hence modeling and computer simulation were carried out to predict radiation chemistry in and around reactor core. G(values) are required to calculate the radiation chemistry. Monte Carlo simulations were used to calculate the G(values) of primary species , H•, H2, •OH dan H2O2 formed from the radiolysis of tritium β low energy electron. These radiolytic products can degrade the reactor components and cause corrosion under the reactor operating conditions. G(values) prediction can indirectly contribute to maintain the material reliability. G(values) were calculated at 10-8, 10-7, 10-6 and 10-5 s after ionization at temperature ranges. The calculation were compared with the G(values) of g-ray 60Co. The work aimed to understand temperature effect on the water radiolysis mechanism by the tritium β electron. The results show that the trend similarity was found on the temperature dependence of G(values) of tritium β electron and g-ray 60Co. For tritium β electron, G(values) for free radical were lower than g-ray 60Co, but higher for molecular products as temperature raise at 10-8 and 10-7. The significant differences for these two type of radiations were on G(H2), G(•OH) and G(H•) at 10-6and 10-5 s above 200 oC.
Pengaruh Penambahan Zeolit pada Proses Pelletizing Limbah Penetasan Terhadap Kandungan Coliform dan Salmonella Produk Pellet
Authors: Wardana Bakhtiar Ali , Sulistiyanto Bambang , Sumarsih Sri 
Published: September 2017

ABSTRAK. Penelitian untuk mengkajipengaruh penambahan zeolit pada proses pelletizing limbah penetasan, terhadap total Coliform dan Salmonella,telah dilaksanakan di Laboratorium Teknologi Pakan, Fakultas Peternakan dan Pertanian, Universitas Diponegoro. Zeolit dilaporkan mampu mengikat berbagai senyawa kimia, termasuk senyawa beracun, serta mampu mempengaruhi aktivitas mikrobia. Penambahan zeolit dalam pelletizing limbah penetasan diharapkan mampu menurunkan total Coliform dan Salmonella dalam produk pellet, sehingga dapat meningkatkan keamanan produk pellet sebagai bahan pakan alternatif. Dosis penambahan zeolit pada pembuatan pellet yaitu: 0, 2, 4 dan 6%. Data dianalisis dengan analisis ragam dan dilanjutkan dengan uji jarak berganda Duncan. Hasil penelitian menunjukkan penambahan zeolit dalam proses Pelletizing limbah penetasan berpengaruh sangat nyata (P0,01) terhadap penurunan total Coliform. Peningkatan dosis zeolite dapat menurunkan Total Coliform dan bakteri Salmonella tidak terdekteksi pada pellet limbah penetasan. Dapat disimpulkan bahwa pelletizing limbah penetasan dengan dosis zeolit hingga 6% terbuktimampu menurunkan kandungan Coliform dan Salmonella pada produk pellet. (Effect administering zeolite in the pelletizing of hatchery waste to contents of coliform and salmonella of the pellet products) ABSTRACT. Experiment to study effect of administering zeolite in the pelletizing hatchery wastes on the total Coliform and Salmonella was done in the Laboratory of Feed Technology, Faculty of Animal Science and Agriculture, University of Diponegoro. Zeolite has been reported have binding capacity on wide range of chemicals, including toxic compounds, and interfere the activity of microbes. Administration zeolite in the pelletizing of hatchery wastes are expected to reduce the total Coliform and Salmonella in the pellet products, therefore improved the safety of the pellet products as an alternative feed ingredients. Doses of zeolite administration in the pelletizing are 0, 2, 4 and 6%. Data were analyzed by analysis of variance (ANOVA) followed by Duncan's multiple range test. The results showed, effect of administering zeolite in the pelletizing hatchery wastes was significant to the total Coliform (P 0.01). Increasing doses of zeolite reduced the Total Coliform and the Salmonella was not detected in the hatchery waste pellets. It could be concluded that pelletizing hatchery waste with a dose of zeolite of up to 6% proven to reduce the content of Coliform and Salmonella in the pellet products.
Efek Suhu dan Masa Simpan Terhadap Aktivitas Antimikroba Susu Fermentasi dengan Lactobacillus casei
Authors: Mirdalisa Cut Afria , Zakaria Yusdar , Nurliana Nurliana 
Published: September 2017

ABSTRAK. Susu fermentasi merupakan susu hasil pengasaman melalui aktivitas bakteri asam laktat yang menyebabkan perubahan kimia, sensorik dan mikrobiologi dalam produk susu fermentasi. Lactobacillus casei merupakan bakteri yang mampu menghasilkan senyawa organik dan hydrogen peroksida yang bersifat antibakteri. Senyawa antibakteri ini adalah senyawa kimiawi atau biologis yang dapat menghambat pertumbuhan dan aktivitas bakteri patogen yang dapat merusak kualitas susu fermentasi. Penelitian ini bertujuan untuk mengetahui pengaruh suhu dan lama penyimpanan terhadap kualitas susu fermentasi dengan Lactobacillus casei. Suhu dan lama penyimpanan pada susu fermentasi Lactobacillus casei pengaruh sangat nyata (P0,01) dan dapat menekan pertumbuhan terhadap bakteri E.coli dan Staphylococcus aureus. Aktivitas antimikroba susu fermentasi Lactobacillus casei pada suhu penyimpanan 5⁰C dengan lama penyimpanan 30 hari dapat menekan pertumbuhan bakteri Staphylococcus aureus. (Effects of temperature and storage time on the antimicrobial activity fermented milk with Lactobacillus casei) ABSTRACT. Fermented milk is milk acidification results through the activity of lactic acid bacteria that causes chemical changes, sensory and microbiological in fermented milk products. Lactobacillus casei is a bacteria that can produce organic compounds and hydrogen peroxide which is antibacterial. The antibacterial compound is a chemical or biological compound that can inhibit the growth and activity of pathogenic bacteria that can damage the quality of fermented milk. The study has been conducted to determine the effect of temperature and storage time on the quality of fermented milk with Lactobacillus casei. the temperature and duration of storage time of fermented milk with Lactobacillus casei highly significant (P 0.01) affected and can suppress the growth of bacteria E.coli and Staphylococcus aureus. The antimicrobial activity of Lactobacillus casei fermented milk at the storage temperature of 5⁰C with a storage time of 30 days can suppress the growth of Staphylococcus aureus.
Hubungan Paritas, Lingkar Dada dan Umur Kebuntingan dengan Produksi Susu Sapi Friesian Holstein di BBPTU-HPT Baturraden
Authors: Filian Bagus Velly , Santoso Sri Agus Bambang , Harjanti Dian Wahyu , Prastiwi Wahyu Dyah 
Published: September 2017

ABSTRAK. Penelitian ini bertujuan untuk mengkaji hubungan paritas, lingkar dada dan umur kebuntingan dengan produksi susu. Penelitian telah dilaksanakan tanggal 28 Desember 2015-30 Maret 2016 di Balai Besar Pembibitan Ternak Unggul dan Hijauan Pakan Ternak Baturraden, Banyumas Jawa Tengah. Materi yang digunakan adalah 34 ekor sapi Friesian Holstein dalam masa laktasi bunting. Metode penelitian yang digunakan adalah metode observasional dengan teknik purposive sampling. Analisis data menggunakan analisis regresi dan uji korelasi dengan bantuan program SPSS versi 16. Variabel independen terdiri dari paritas, lingkar dada dan umur kebuntingan serta variabel dependen terdiri dari produksi susu rata- rata harian dan satu masa laktasi. Hasil penelitian menunjukkan bahwa ukuran lingkar dada rata-rata dari paritas I sampai V berturut turut adalah 180 ± 7,8 cm, 199 ± 9,7 cm, 201 ± 9,4 cm, 207 ± 11,7 cm dan 200 ± 4,2 cm. Produksi susu rata - rata satu masa laktasi 4025,2 + 1395,6 kg (13,2 ± 4,6 kg/hari). Paritas, lingkar dada dan umur kebuntingan tidak memiliki hubungan yang nyata dengan produksi susu (p 0,05). Kesimpulan dari penelitian ini menunjukkan bahwa produksi susu tidak memiliki hubungan dengan paritas, lingkar dada dan umur kebuntingan. (The relationship between parity, chest circumference and gestational age with milk yield of Friesian Holstein in BBPTU-HPT Baturraden) ABSTRACT. This study investigated the relationship between milk yield and parity, chest circumference, gestation age in lactating pregnant dairy cow. Research was conducted in December 28, 2015-March 30, 2016 at the Balai Besar Pembibitan Ternak Unggul dan Hijauan Pakan Ternak Baturraden, Banyumas, Central Java. Recording data from 34 pregnant dairy cows were used in this study. The observational method with purposive sampling technique was used. The data were analyzed using regression analysis and correlation with SPSS version 16. The independent variables were parity, chest circumference and gestation age, whereas the dependent variable was milk yield. The result showed that the chest circumference of the cow were 180 ± 7,8 cm, 199 ± 9,7 cm, 201 ± 9,4 cm, 207 ± 11,7 cm and 200 ± 4,2 cm for the 1st to 5th parity, respectively. Total milk yield for 305 days of lactation period was 4025,2 ± 1395,6 kg (13,2 ± 4,6 kg/d). There were no significant correlations between parity, chest circumference and gestational age with milk yield (p0.05). It is suggested that milk yield is not strongly related to parity, chest circumference and gestational age.
Analisis Kepuasan Konsumen Terhadap Kue Baytat Bengkulu
Authors: Kurniati Eka , Silvia Evanila , Efendi Zulman 
Published: September 2017

The aim of research was to identify the attributes that baytat consumers want, determine the customer satisfaction of baytat cake and get a map attributes of baytat cake. Locations were selected intentionally (purposive). Variables and attributes used are: 1) quality of product (color of cake, aroma of cake, texture of cake, taste of cake, and the shelf life of product), 2) packaging products (appeal illustration, color packaging, capabilities of packaging to protect the product, practicality packaging) and 3) price of product. Identify the attributes that consumers want analyzed by validity and reliability test; used 22 respondents. Level of customer satisfaction was analyzed by CSI (Customer Satisfaction Index) and map attributes were analyzed using Importance Performance Analysis (IPA); total respondents are 100 consumers with convenience sampling technique. The results showed that the attributes that consumers want baytat is an attraction illustration, color packaging, packaging capabilities protect products, practical packaging, the color of the cake, cake aroma, the texture of the cake, cake flavor, shelf life of products and product prices. CSI analysis results indicate the level of customer satisfaction with cake baytat of 80.41%. Map quadrant of the following attributes: quadrant 1 (the color of the cake and the price of the product), Quadrant II (cake flavor, aroma of cookies and texture of the cake), Quadrant III (packaging capabilities, appeal of the packaging and packaging color) and Quadrant IV (the shelf life of product and practicality packaging).