bluuebunny/crossref_metadata_2025_split huggingface dataset:
Binary response panel data models with sample selection and self‐selection
Authors: Semykina Anastasia , Wooldridge Jeffrey M. 
Published: August 2017

SummaryWe consider estimating binary response models on an unbalanced panel, where the outcome of the dependent variable may be missing due to nonrandom selection, or there is self‐selection into a treatment. In the present paper, we first consider estimation of sample selection models and treatment effects using a fully parametric approach, where the error distribution is assumed to be normal in both primary and selection equations. Arbitrary time dependence in errors is permitted. Estimation of both coefficients and partial effects, as well as tests for selection bias, are discussed. Furthermore, we consider a semiparametric estimator of binary response panel data models with sample selection that is robust to a variety of error distributions. The estimator employs a control function approach to account for endogenous selection and permits consistent estimation of scaled coefficients and relative effects.
A Full Regioselective and Stereoselective Synthesis of 4‐Nitroisoxazolidines via Stepwise [3 + 2] Cycloaddition Reactions between (Z)‐C‐(9‐Anthryl)‐N‐arylnitrones and (E)‐3,3,3‐Trichloro‐1‐nitroprop‐1‐ene: Comprehensive Experimental and Theoretical Study
Authors: Jasiński Radomir , Żmigrodzka Magdalena , Dresler Ewa , Kula Karolina 
Published: August 2017

In the contrast to all known [3 + 2] cycloadditions between nitrones and conjugated nitroalkenes, reactions of (E)‐3,3,3‐trichloro‐1‐nitroprop‐1‐ene with (Z)‐C‐(9‐anthryl)‐N‐arylnitrones are proceeding in a fully regioselective and stereoselective manner. Additionally, density functional theory calculations suggest stepwise, zwitterionic mechanism of these cycloadditions.
Magnetically‐actuated drug delivery device (MADDD) for minimally invasive treatment of prostate cancer: An in vivo animal pilot study
Authors: Struss Werner J. , Tan Zheng , Zachkani Payam , Moskalev Igor , Jackson John K. , Shademani Ali , D'Costa Ninadh M. , Raven Peter A. , Frees Sebastian , Chavez‐Munoz Claudia , Chiao Mu , So Alan I. 
Published: August 2017

BackgroundThe vast majority of prostate cancer presents clinically localized to the prostate without evidence of metastasis. Currently, there are several modalities available to treat this particular disease. Despite radical prostatectomy demonstrating a modest prostate cancer specific mortality benefit in the PIVOT trial, several novel modalities have emerged to treat localized prostate cancer in patients that are either not eligible for surgery or that prefer an alternative approach.MethodsAthymic nude mice were subcutaneously inoculated with prostate cancer cells. The mice were divided into four cohorts, one cohort untreated, two cohorts received docetaxel (10 mg/kg) either subcutaneously (SC) or intravenously (IV) and the fourth cohort was treated using the magnetically‐actuated docetaxel delivery device (MADDD), dispensing 1.5 μg of docetaxel per 30 min treatment session. Treatment in all three therapeutic arms (SC, IV, and MADDD) was administered once weekly for 6 weeks. Treatment efficacy was measured once a week according to tumor volume using ultrasound. In addition, calipers were used to assess tumor volume.ResultsAnimals implanted with the device demonstrated no signs of distress or discomfort, neither local nor systemic symptoms of inflammation and infection. Using an independent sample t‐test, the tumor growth rate of the treated tumors was significant when compared to the control. Post hoc Tukey HSD test results showed that the mean tumor growth rate of our device cohort was significantly lower than SC and control cohorts. Moreover, IV cohort showed slight reduction in mean tumor growth rates than the ones from the device cohort, however, there was no statistical significance in tumor growth rate between these two cohorts. Furthermore, immunohistochemistry demonstrated an increased cellular apoptosis in the MADDD treated tumors and a decreased proliferation when compared to the other cohorts. In addition, IV cohort showed increased treatment side effects (weight loss) when compared to the device cohort. Finally, MADDD showed minimal expression of CD45 comparable to the control cohort, suggesting no signs of chronic inflammation.ConclusionsIn conclusion, this study showed for the first time that MADDD, clearly suppressed tumor growth in local prostate cancer tumors. This could potentially be a novel clinical treatment approach for localized prostate cancer.
Seven‐year monitoring of pyrethroid resistance in the pollen beetle (Brassicogethes aeneus F.) during implementation of insect resistance management
Authors: Stará Jitka , Kocourek František 
Published: August 2017

AbstractBACKGROUNDAn increase in the spread of pyrethroid resistance in the pollen beetle has been documented in many European countries. Pyrethroid resistance in the pollen beetle in the Czech Republic has been detected using a topical application bioassay. Resistance monitoring has been carried out during the implementation of insect resistance management.RESULTSThe susceptibilities of nine pollen beetle populations to four pyrethroids in 2009 − 2015 in the Czech Republic are presented in this paper. The highest resistance ratio (RR) values [based on the lethal dose for 50% of the population (LD50)] obtained for deltamethrin, lambda‐cyhalothrin, tau‐fluvalinate and etofenprox were 500, 299, 108 and 66.9, respectively. Pollen beetle mortality after application of deltamethrin or lambda‐cyhalothrin gradually decreased from 2009 to 2013. High cross‐resistance between lambda‐cyhalothrin and deltamethrin and low cross‐resistance between lambda‐cyhalothrin and etofenprox were demonstrated. A kdr mutation known to cause resistance in the pollen beetle was not detected.CONCLUSIONA high level of resistance was recorded in most of the nine populations of the pollen beetle in 2013. In the following 2 years, a decrease in resistance associated with a population density decrease of the pollen beetle was observed in all nine populations as a result of insect resistance management based on pyrethroid reduction in winter oilseed rape. © 2017 Society of Chemical Industry
Highly Compressible Integrated Supercapacitor–Piezoresistance‐Sensor System with CNT–PDMS Sponge for Health Monitoring
Authors: Song Yu , Chen Haotian , Su Zongming , Chen Xuexian , Miao Liming , Zhang Jinxin , Cheng Xiaoliang , Zhang Haixia 
Published: August 2017

AbstractRapid improvement of wearable electronics stimulates the demands for the matched functional devices and energy storage devices. Meanwhile, wearable microsystem requires every parts possessing high compressibility to accommodate large‐scale mechanical deformations and complex conditions. In this work, a general carbon nanotube–polydimethylsiloxane (CNT–PDMS) sponge electrode is fabricated as the elementary component of the compressible system. CNT–PDMS sponge performs high sensitivity as a piezoresistance sensor, which is capable of detecting stress repeatedly and owns great electrochemical performance as a compressible supercapacitor which maintains stably under compressive strains, respectively. Assembled with the piezoresistance sensor and the compressible supercapacitor, such highly compressible integrated system can power and modulate the low‐power electronic devices reliably. More importantly, attached to the epidermal skin or clothes, it can detect human motions, ranging from speech recognition to breathing record, thus showing feasibility in real‐time health monitor and human–machine interfaces.
Inhibitory effect of ucha‐shinki‐hwan on cold‐mediated response in human dermal microvascular endothelial cells
Authors: Lee Kangwook , Cho Sung‐Gook , Lee Gyu Ri , Choi Yu‐Jeong , Go Ho Yeon , Sun Seung‐Ho , Kim Tae‐Hun , Park Jong‐Hyeong , Choi You‐Kyung , Lee Hesol , Jung Ki‐Yong , Song Yun‐Kyung , Jeon Chan‐Yong , Ko Seong Gyu 
Published: August 2017

ABSTRACTAimRaynaud's phenomenon is characterized by prolonged vasoconstriction in cutaneous capillaries on cold stress. RhoA activity would be a therapeutic target for treating Raynaud's phenomenon. A traditional herbal medicine, ucha‐shinki‐hwan, has been used to promote vasodilation, but the biological mechanism of ucha‐shinki‐hwan is still unclear. Thus, we hypothesized that ucha‐shinki‐hwan is able to be used for treatment of Raynaud's phenomenon and that ucha‐shinki‐hwan inhibits cold‐induced vasoconstriction by targeting RhoA GTPase.MethodsHuman dermal microvascular endothelial cells were pretreated with ucha‐shinki‐hwan for 30 min, followed by incubation in room temperature (37 ± 2°C) or a lower temperature (25 ± 2°C) for 30 min. Expression of active RhoA was measured on western blot. Endothelin‐1 and nitric oxide production were examined on enzyme‐linked immunosorbent assay. The formation of stress fiber and focal adhesion complex was analyzed using immunocytochemistry.ResultsCold exposure activated RhoA GTPase whereas ucha‐shinki‐hwan treatment suppressed its activation in human dermal microvascular endothelial cells. Moreover, ucha‐shinki‐hwan decreased cold‐induced endothelin‐1 and nitric oxide production. In addition, ucha‐shinki‐hwan treatment inhibited the formation of stress fiber and focal adhesion complex with downregulation of focal adhesion kinase (FAK), SRC kinase and extracellular regulated kinases (ERK) phosphorylation.ConclusionUcha‐shinki‐hwan inhibits contraction of cold‐exposed human dermal microvascular endothelial cells by targeting RhoA activation. This in vitro study is therefore the first to suggest that ucha‐shinki‐hwan is likely to be effective for inhibiting cold‐induced response in vascular endothelial cells.
Cropping system intensification: vegetable pea can replace fallow between rainfed monsoon rice and irrigated spring rice
Authors: MALIK A. I. , NASIM M. , FLOWER K. , HOSSAIN M. A. , RAHMAN M. S. , ANWAR B. , ALI M. O. , RAHMAN M. M. , ERSKINE W. 
Published: August 2017

SUMMARYThe Eastern Gangetic Plain is among the world's most intensively farmed regions, where rainfed and irrigated agriculture coexist. While the region and especially Bangladesh is a major producer of rice (Oryza sativaL. ssp.indica), there is potential to further develop sustainable rice production systems. Specifically, there is scope to include a replacement crop for the short fallow between rice crops in the dominant cropping pattern of rainfed monsoon rice harvest followed by irrigated spring rice. The aim of the current research was to identify a suitable cool-season legume crop – pea (Pisum sativumL.) or lentil (Lens culinarisMedik. ssp.culinaris) – that could be grown in the brief period between rice crops. The study comprised four crop sequence experiments comparing legume cultivars differing in maturity grown in between both long and short duration rice cultivars. These experiments were done at the Bangladesh Rice Research Institute regional station at Rajshahi over three cropping cycles. This was followed by an evaluation of pea vs. fallow between rice crops on three farmers’ fields in one cropping cycle. Here it is demonstrated that green pod vegetable pea is one of the best options to intensify the rainfed monsoon rice–fallow–spring irrigated rice cropping system, notwithstanding other remunerative rabi cropping options that could displace boro rice. The inclusion of an extra crop, pea as green pod vegetable, increased farm productivity by 1·4-fold over the dominant cropping sequence (rice–fallow–rice) and farm net income by fourfold. The study highlighted the advantages in total system productivity and monetary return of crop intensification with the inclusion of a pea crop between successive rice crops instead of a fallow period.
The word(s) the Spirit gives: Lutheran and Reformed exegesis of 1 Corinthians 2:13
Authors: Harris Steven Edward 
Published: August 2017

AbstractDistinctive Lutheran and Reformed theologies of the relationship between Word and Spirit influenced the history of Protestant exegesis of 1 Corinthians 2:13, which states, ‘we speak not in words taught by human wisdom, but in those taught by the Spirit’. The interpretation of the time of the Spirit's teaching (past or present) and the identity of the words taught (scripture or preaching/teaching) are seen to depend upon and develop these respective Lutheran and Reformed theologies. The essay concludes with a brief evaluation of the adequacy of these interpretations in light of the divine economy and some ecumenical considerations.
Neither Centre nor Local: Community-Driven Experimentalist Governance in China
Authors: Shin Kyoung 
Published: August 2017

AbstractBased on findings from three years of site-intensive fieldwork at the local level, this article presents evidence to suggest that binary governance frameworks like centre–local relations are insufficient to understand certain local regulatory outcomes in contemporary China. I seek to specify a distinct type of local governance that has been emerging in recent years, which blurs existing binary concepts. It can be distinguished along two main dimensions: ostensible structure and modalities of governance. Two cases are analysed to illustrate the ways in which it impacts local regulatory outcomes. The analyses point to the need for expanding our portfolio of approaches to understanding local governance in contemporary China.
Implementation of Pollution Control Targets in China: Has a Centralized Enforcement Approach Worked?
Authors: Zhang Xuehua 
Published: August 2017

AbstractThe scholarly work on China's environmental regulations in the context of “central–local” relations is dominated by the preference for a centralized approach. This article examines a centrally imposed and executed verification programme of locally reported pollution data, a rare and sustained central effort to enforce an environmental policy, namely the national pollution reduction target system. The programme was established in 2007 to curtail perceived widespread data falsification and to enhance the quality of emission data, the basis for assessing local compliance with targets. Based on an analysis of official documents and interviews with environmental officials and industry representatives, this article found that the verification programme appears to have reduced the overreporting problem with emission data, enhanced local monitoring and enforcement capacity, and to a certain degree deterred violations due to the increased frequency of national and local inspections. Nevertheless, significant challenges remain. Verification is highly resource intensive, it has involved little external oversight and public participation, the central authority has exerted significant yet unchecked discretionary powers, and poor data quality has remained an issue. Over time, the verification programme appears to have turned into essentially a “numbers game.” All those challenges indicate that a centralized enforcement approach is arguably ineffective in addressing China's long-standing problem of weak environmental policy implementation. This study also sheds lights on the classical “principal-agent” theory in the study of public bureaucracy. Not only does the principal distrust the agent, which is the main concern of the theory, but the agent also distrusts the principal.
Periurban outbreaks of bovine calf scours in Northern India caused byCryptosporidiumin association with other enteropathogens
Authors: BRAR A. P. S. , SOOD N. K. , KAUR P. , SINGLA L. D. , SANDHU B. S. , GUPTA K. , NARANG D. , SINGH C. K. , CHANDRA M. 
Published: August 2017

SUMMARYBovine calf scours reported to be caused by multiple aetiologies resulting in heavy mortality in unweaned calves and huge economic loss to the dairy farmers. Among these, cryptosporidiosis is an emerging waterborne zoonoses and one of the important causes of neonatal calf diarrhoea. Poor immune response coupled with primary cryptosporidial infections predispose neonatal calves to multiple secondary infections resulting in their deaths. In the present study, faecal samples from 100 diarrhoeic calves randomly picked up out of 17 outbreaks of bovine calf diarrhoea in periurban Ludhiana, Punjab in Northern India were subjected to conventional (microscopy, modified Zeihl–Neelsen (mZN) staining) and immunological and molecular techniques (faecal antigen capture ELISA and PCR) for detection of primaryCryptosporidium parvuminfection as well as other frequently reported concurrent pathogens,viz. rotavirus and coronavirus,Salmonellaspp.,Escherichia coli,Clostridium perfringensandEimeriaspp. The faecal antigen capture ELISA and PCR revealed 35% prevalence ofC. parvumin contrast to 25% by mZN staining with a relatively higher prevalence (66·7%) in younger (8–14-day-old) calves. The detection rate of the other enteropathogens associated withC. parvumwas 45·71% forC. perfringensfollowed bySalmonellaspp (40·0%), rotavirus (36·0%), coronavirus (16·0%),E. coli(12·0%) andEimeriaspp (4·0%) The sensitivity for detection ofC. parvumby ELISA and mZN staining in comparison to PCR was 97·14% and 72·72%, respectively. An important finding of the study was thatC. parvumalone was found in only 10% of the diarrhoeic faecal samples, whereas, majority of the samples (90%) showed mixed infections ranging from a combination of two to five agents. This is the first documentary proof ofC. parvumand associated pathogens responsible for severe periurban outbreaks of bovine calf diarrhoea culminating in heavy mortality from Northern India.
Genital HPV infection among heterosexual and homosexual male attendees of sexually transmitted diseases clinic in Beijing, China
Authors: XIN H.N. , LI H.J. , LI Z. , LI X.W. , LI M.F. , ZHANG H.R. , FENG B.X. , LUN W.H. , YAN H.W. , LONG J. , GAO L. 
Published: August 2017

SUMMARYHuman papillomavirus (HPV) has been identified as etiologic agent of various cancers for both men and women. However, HPV vaccine has not been recommended for men in China by far. To provide more evidences to promote HPV vaccination among males at high-risk of infection, this study investigated genital HPV genotypes among male attendees of sexually transmitted disease (STD) clinic. Male attendees (⩾18 years old) were recruited from STD clinic of Beijing Ditan Hospital. Data on sociodemographic characteristics and self-reported sexual behaviors were collected based on questionnaire. Genital swab specimens were collected for HPV genotypes. Finally, a total of 198 eligible participants were included in the study. Nearly half of them were infected with at least one type of HPV. The prevalence of genital infection among participants with only heterosexual behaviors (50·91%, 56/110) was significantly higher than those with only homosexual behaviors (36·36%, 32/88) (P< 0·001). However, the distribution pattern of the most frequently observed HPV subtypes were found to be similar between these two subgroups. HPV31, HPV18, HPV16 and HPV58 were the most frequently identified high-risk types and HPV11, HPV6, HPV81 and HPV61 were the most frequently observed low-risk types. Our results, although need further verification by larger sample size, suggested that currently available HPV vaccines covered most prevalent HPV types observed in Chinese men. As HPV vaccine has been approved for application in females in China, molecular epidemiological studies and intervention studies among high-risk males should be promoted as well.
Pulmonary vasodilator therapy in tetralogy of Fallot with pulmonary atresia and major aortopulmonary collaterals: case series and review of literature
Authors: Apostolopoulou Sotiria C. , Vagenakis George , Rammos Spyridon 
Published: August 2017

AbstractWe present the use of pulmonary vasodilators in three adult patients with unrepaired tetralogy of Fallot, pulmonary atresia, aortopulmonary collaterals, and segmental pulmonary arterial hypertension. Patients improved by 1–2 NYHA classes with modest exercise-tolerance increase, and remained stable without side effects during 2.5, 10, and 14 years. Literature review revealed five studies with pulmonary vasodilators in heterogeneous, mostly repaired patient populations.
Perinatal and early postnatal outcomes for fetuses with prenatally diagnosed d-transposition of the great arteries: a prospective cohort study assessing the effect of standardised prenatal consultation
Authors: Qu Yanji , Wen Shusheng , Liu Xiaoqing , Pan Wei , Han Fengzhen , Mai Jinzhuang , Ou Yanqiu , Nie Zhiqiang , Gao Xiangmin , Wu Yong , Ohye Richard G. , Chen Jimei , Zhuang Jian 
Published: August 2017

AbstractBackgroundThe aim of this study was to explore perinatal and early postnatal outcomes in fetuses with prenatally diagnosed d-transposition of the great arteries and impacts of standardised prenatal consultation.MethodsAll fetuses with prenatally diagnosed d-transposition of the great arteries prospectively enrolled at South China cardiac centre from 2011 to 2015. Standardised prenatal consultation was introduced in 2013 and comprehensive measures were implemented, such as establishing fetal CHD Outpatient Consultation Service, performing standard prenatal consultation according to specifications, and establishing a multidisciplinary team with senior specialists performing in-person consultations. Continuous follow-up investigation was conducted. Perinatal and postnatal outcomes were compared before and after consultation including live birth, elective termination of pregnancy, spontaneous fetal death, stillbirths, referral for surgery, and survival.ResultsIn all, 146 fetuses were enrolled with 41 (28%) lost to follow-up. Among 105 remaining fetuses, 29 (28%) were live births and 76 (72%) were terminated. After consultation, live birth rate was higher (50 versus 33%) and termination rate was lower (50 versus 76%), although there was no statistical significance. Excluding three live births without postnatal d-transposition of the great arteries, 65% (17/26) underwent arterial switch operation within 30 days. A total of three in-hospital deaths occurred and during the 10-month follow-up period, one death was observed. In one case, the switch procedure was performed at 13 months and the infant survived. Out of eight infants without arterial switch operation, two died.ConclusionsLive birth rate increased after consultation; however, termination remained high. Combining termination, patients without arterial switch operation, and operative mortality, outcomes of d-transposition of the great arteries infants can be improved. Standard consultation, multidisciplinary collaboration, and improved perinatal care are important to improve outcomes.
Coronary artery spasm in a neonate with transposition of great arteries: a rare complication and reason for heart transplant
Authors: Bansal Neha , Delius Ralph E. , Aggarwal Sanjeev 
Published: August 2017

AbstractArterial switch operation has become the standard of care for d-transposition of great arteries and has excellent short- and long-term outcomes. We report the case of a newborn with a diagnosis of d-transposition of great arteries with intact ventricular septum and a low-risk coronary artery anatomy who developed coronary artery vasospasm while coming off bypass following arterial switch operation in the operating room. The coronary artery spasm led to severe biventricular dysfunction and need for extracorporeal membranous oxygenation support. Despite extracorporeal membranous oxygenation and inotropic support, there was no improvement in the left ventricular function, and cardiac transplantation was performed after 8 days. The explanted heart showed extensive infarction of both ventricles. Both the coronary ostei were patent with no evidence of thrombus, suggesting coronary artery vasospasm rather than embolus or thrombus formation. This is the first case of coronary artery vasospasm in a neonate with d-transposition of great arteries leading to cardiac transplantation. We speculate that early identification of patients who are at a high risk for coronary vasospasm and prophylactic or timely infusion of papaverine directly into the coronary arteries may be beneficial in this condition.