bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-Talk Between Mitochondrial Fusion and the Hippo Pathway in Controlling Cell Proliferation DuringDrosophilaDevelopment
Authors: Deng Qiannan , Guo Ting , Zhou Xiu , Xi Yongmei , Yang Xiaohang , Ge Wanzhong 
Published: June 2016

AbstractCell proliferation and tissue growth depend on the coordinated regulation of multiple signaling molecules and pathways during animal development. Previous studies have linked mitochondrial function and the Hippo signaling pathway in growth control. However, the underlying molecular mechanisms are not fully understood. Here we identify a Drosophila mitochondrial inner membrane protein ChChd3 as a novel regulator for tissue growth. Loss of ChChd3 leads to tissue undergrowth and cell proliferation defects. ChChd3 is required for mitochondrial fusion and removal of ChChd3 increases mitochondrial fragmentation. ChChd3 is another mitochondrial target of the Hippo pathway, although it is only partially required for Hippo pathway-mediated overgrowth. Interestingly, lack of ChChd3 leads to inactivation of Hippo activity under normal development, which is also dependent on the transcriptional coactivator Yorkie (Yki). Furthermore, loss of ChChd3 induces oxidative stress and activates the JNK pathway. In addition, depletion of other mitochondrial fusion components, Opa1 or Marf, inactivates the Hippo pathway as well. Taken together, we propose that there is a cross-talk between mitochondrial fusion and the Hippo pathway, which is essential in controlling cell proliferation and tissue homeostasis in Drosophila.
Covariance Association Test (CVAT) Identifies Genetic Markers Associated with Schizophrenia in Functionally Associated Biological Processes
Authors: Rohde Palle Duun , Demontis Ditte , Cuyabano Beatriz Castro Dias ,   The Genomic Medicine for Schizophrenia Group, Børglum Anders D , Sørensen Peter 
Published: June 2016

Abstract
Schizophrenia is a psychiatric disorder with large personal and social costs, and understanding the genetic etiology is important. Such knowledge can be obtained by testing the association between a disease phenotype and individual genetic markers; however, such single-marker methods have limited power to detect genetic markers with small effects. Instead, aggregating genetic markers based on biological information might increase the power to identify sets of genetic markers of etiological significance. Several set test methods have been proposed: Here we propose a new set test derived from genomic best linear unbiased prediction (GBLUP), the covariance association test (CVAT). We compared the performance of CVAT to other commonly used set tests. The comparison was conducted using a simulated study population having the same genetic parameters as for schizophrenia. We found that CVAT was among the top performers. When extending CVAT to utilize a mixture of SNP effects, we found an increase in power to detect the causal sets. Applying the methods to a Danish schizophrenia case–control data set, we found genomic evidence for association of schizophrenia with vitamin A metabolism and immunological responses, which previously have been implicated with schizophrenia based on experimental and observational studies.
Montenegrin Teachers’ Perception of the Acquisition of Literary Terms in Primary School/Mišljenja učitelja o usvajanju književnoteorijskih pojmova u nižim razredima osnovane škole u Crnoj Gori
Authors: Vučković Dijana Lj 
Published: June 2016

Abstract This paper discusses a teaching methodology approach to the acquisition of literary terms in the lower grades (1 to 5) of primary schools in Montenegro. In the first part of the paper, the author presents the theoretical framework of the research problem, giving a short analysis of the curriculum. The objective of this study was to identify teachers' opinions on the adoption of literary terms in the lower grades. The technique of focus interviewing was used on a sample of 45 classroom teachers. The research results have proved that teachers fail to devote enough attention to literary and theoretical concepts. Their personal opinion is that they are not satisfied with the cognitive effects of teaching literature. Some of the reasons given can be categorized as objective difficulties, while there are those that should be recognized as a need for additional training for teachers. The results of this study correspond with findings reported by numerous authors and with nearly unanimous assessment of experts that teaching literature must be reformed in many ways if we wish the crisis of reading as a global phenomenon to start being systematically treated from the very beginning of compulsory education.Key words: curriculum; literary genres and subgenres; student; teaching methodology approach; workbook. --- SažetakU radu se razmatra metodički pristup usvajanju književnoteorijskih pojmova u nižim razredima (1. do 5.) osnovane škole u Crnoj Gori. U uvodnom dijelu prezentirane su teorijske osnovae istraživačkog problema i dana je kratka analiza kurikula. Cilj istraživanja bio je identificirati mišljenja učitelja o usvajanju književnoteorijskih pojmova u nižim razredima. Primijenjena je tehnika fokus intervjuiranja, a uzorak čini 45 učitelja razredne nastave. Rezultati istraživanja pokazuju da učitelji ne uspijevaju u nastavi dovoljno pozornosti posvetiti književnoteorijskim pojmovima. Njihova je osobna ocjena da nisu zadovoljni spoznajnim učinkom nastave književnosti. Neki od razloga koje su naveli mogu se kategorizirati kao objektivne poteškoće, a ima i onih koje bismo morali prepoznati kao potrebu za dodatnim obraziranjem nastavnog kadra. Rezultati ovog istraživanja korespondiraju s rezultatima mnogih autora i s gotovo jednodušnom ocjenom stručnjaka da nastava književnosti u mnogo čemu mora biti reformirana ako želimo da se kriza čitanja kao globalni fenomen napokon počne sustavno tretirati još od samog početka obvezne edukacije. Ključne riječi: čitanka; književni rodovi i vrste; metodički pristup; nastavni program; učenik.
The Journey from the Inferno to the Purgatory: Eliot’s Religious Odyssey
Authors: Hammad Iman Morshed 
Published: June 2016

The poetry of T.S. Eliot is akin to a full term conception of spiritual faith that inevitably ushers in the birth of spiritual salvation after a long period of suffering and labour. This pattern is not perceived in one single poem or a specific collection of poems, but rather in the entire corpus of Eliot’s poetry. It is rendered tangible when we trace the process of questing for spiritual faith in his early poetry where the need for faith is the sorest after the panorama of suffering that the human beings brought upon themselves. Throughout his poetic career, Eliot attributed this suffering to mere futility, greedy materialism and loveless existence marred by lechery rather than genuine feelings. This paper tries to prove that Eliot’s poetry delineates a mental process that takes the reader from the inferno of contemporary life to the purgatory of religious faith which is potentially capable of lifting Man before falling into the abyss of loss. This being said, the paper aims at drawing the features of Eliot’s perception of salvation which seems similar to a piece of mosaic which gets clearer and clearer as every piece is put in its proper place.
On the Relationship between Willingness to Communicate and Decultuartion
Authors: Nasiri Mahdi , Suzani Mojde , Babamoradi Parvin , Mohammadi Nasrin 
Published: June 2016

Language learning issues coupled with cultural concerns have been the focus of language researchers within the last decades. This study makes an innovative attempt to scrutinize a new concept in cultural issues, i.e. deculturation. Hence, the relationship between willingness to communicate (WTC), one of the most controversial issues in language learning circles, and deculturation was the matter of research in this study. As far as the sample of current study was concerned, 50 upper- intermediate female English students were selected from among 80 participants from Radmehr English Language Centre in Shariar, Iran. The data was collected by means of two kinds of questionnaires, a Home Culture Attachment Scale (HCAS) and Willingness to Communicate (WTC) questionnaire. The results of the study revealed that there were meaningful relationships between the underlying constructs of the deculturation questionnaire (consisting constructs such as Religious, Iranian, Cultural, Artistic and Western Attachments) and WTC. One of the correlations demonstrated that Deculturation applied mostly for those who were willing to communicate inside the classroom. The implications of this study will best suit language practitioners and language policy makers.
Identificação de impactos ambientais em emprendimento ou atividade de indústria química
Authors: Freitas G. P. , Silva K. A. , Sá G. B. , Rodrigues Segundo S. T. L. , Dantas M. K. L. 
Published: June 2016

<p class="Default"><strong>Resumo: </strong>A indústria química apresenta uma enorme variedade de processos e produtos, podendo ser considerado o setor mais diversificado da área industrial. É também o setor industrial sobre o qual se concentram de maneira mais intensa as preocupações quanto à contaminação ambiental. Objetivou-se com o trabalho destacar os aspectos ambientais dessa atividade e identificando os principais impactos ambientais provenientes deste empreendimento decorrentes das fases de planejamento, implantação e operação. Foi realizada uma revisão da literatura acerca de indústrias químicas e consultas a EIA/RIMAs, apresentando seus principais impactos potenciais e significativos (positivos e negativos), nas diversas fases do empreendimento. Tais impactos foram identificados a partir do método de Avaliação de Impactos Ambientais, listagem de controle simples (<em>Check lists</em>). Os principais impactos identificados foram compactação do solo, alteração nas características do solo, contaminação de rios e aquíferos, aumento da geração de empregos e aumento da perspectiva de vida da população. </p><pre><strong><em>Identification of environmental impacts in</em></strong> <strong><em>enterprise or chemical industry activity</em></strong></pre><pre><strong>Abstract: </strong>The chemical industry has a wide range of processes and products, and can be considered the most diverse sector of the industrial area. It is also the industrial sector on which they focus more intensively concerns about environmental contamination. From information gathered, the literature, the aim of this study is to highlight the importance of the chemical industry, as well as out on the environmental aspects of this activity and identify and assess the main environmental impacts from this development resulting from the stages of planning, implementation and operation of the enterprise. The methodology was carried out a literature review about chemical industries and consultations EIA / RIMA, with its major potential and significant impacts (positive and negative) in the various stages of the project. These impacts were identified from the Environmental Impact Assessment method, simple control Listing (check lists). The main impacts were identified soil compaction, changes in soil characteristics, pollution of rivers and aquifers, increased employment generation and increase in population life expectancy.</pre>
Uso eficiente da água de chuva armazenada em cisterna para produção de hortaliças no Semiárido pernambucano
Authors: Ferreira Elvis Pantaleão , Brito Luiza Teixeira de Lima , Nascimento Tarcizio , Rolim Neto Fernando Cartaxo , Cavalcanti Nilton De Brito 
Published: June 2016

<p>O Semiárido brasileiro requer uma particular atenção, dada à irregularidade das precipitações pluviométricas que ocorrem na a região. A cisterna tipo Calçadão do programa Uma Terra e Duas Águas – P1+2 assegura melhoria na dieta alimentar das famílias rurais, por permitir a inserção de alimentação. Com o presente trabalho objetivou-se avaliar o uso eficiente da água empregada sob diferentes lâminas durante todo o ano de 2014, visando a produção de hortaliças no Semiárido pernambucano, com água de chuva armazenada em cisterna do P1+2. Para tanto, foram construídos dois canteiros, denominados 1 e 2, cada um com área de 4 m<sup>2</sup>, para produção de hortaliças, sendo aplicadas, respectivamente, lâminas de 8 mm dia<sup>-1 </sup>e 4 mm dia<sup>-1</sup>, durante todo o ano. Á água foi aplicada de forma manual, utilizando-se regador plástico. A melhor relação água/produção foi obtida com a aplicação de uma lâmina de 4 mm dia<sup>-1</sup>, suficiente para proporcionar o consumo diário de 33,71 gramas de hortaliças na alimentação de uma família.</p><p align="center"><strong><em>Efficient use of stored rain water in cistern to vegetable production in Semiarid pernambucano</em></strong></p><p><strong>Abstract</strong><strong>: </strong>The Brazilian semiarid requires particular attention, given the irregularity of rainfall occurring in the region. The cistern program One Land and Two Waters - P1 + 2 ensures improvement in the diet of rural families by allowing the power input. The present study aimed to evaluate the efficiency of water used in different depths throughout the year 2014, aimed at producing vegetables in Pernambuco semiarid, with rainwater stored in cistern of P1 + 2. For this were constructed, two bed, called 1 and 2, each with an area of 4 m2 for vegetable production, and were applied, respectively, 8 mm blades day 1 and 4 mm Day-1 during the whole year. The water was applied manually, using plastic watering. The best result water/production was obtained with the application of a lamina 4 mm per day, sufficient to provide the consumption of 33.71 grams per day in vegetables in the family diet.</p>
Catalyst
Authors: Tandoc III Amado 
Published: June 2016

The Philippine Journal of Pathology (PJP) was envisioned as a biannual publication of the Philippine Society of Pathologists, Inc. (PSP, Inc.), to serve as an avenue for research by Filipino anatomic and clinical pathologists. It was conceived in 1986 through the efforts of Drs. Antonia Cruz-Basa and Generoso Basa who saw the need for an official journal for the society where original pathology research can be published and which shall hopefully stimulate a culture of publication for the pathology community in the Philippines.
It has been a little over a year since we presented the prospects of resurrecting the Philippine Journal of Pathology at the 64th Annual Convention of the PSP. The revival of the journal would not have been possible without the full support of the current and past PSP President, Dr. Januario Veloso and Dr. Linda Tamesis, respectively, the Board of Governors, our dedicated editorial coordinator, and the members of our Core Team with whom we have begun this journey of revival back in 2012.
It only takes a spark, to get a fire going. The first issue of this journal is a push, a catalyst, to create change. You are part of this drive towards elevating our practice and informing the greater research community of pathology research in this part of the globe.
MAX GLÜCKSMANN: SUS PRIMEROS PASOS EN LA “CASA LAPAGE”. DESCUBRIENDO AL PIONERO DEL CINEMATÓGRAFO
Authors: Gómez Gabriela Ximena 
Published: June 2016

Este artículo forma parte de un trabajo más amplio en el marco de un proyecto de investigación. Este espacio se ocupa de las industrias culturales en la ciudad de Buenos Aires entre el inicio del siglo XX y el final de entreguerras. En ese contexto, lo que me interesa es observar el recorrido de un pionero de la industria del espectáculo, fotógrafo, director, productor, distribuidor, etc., el empresario austríaco Max Glücksmann. Junto a la transformación que vivió la ciudad de Buenos Aires desde finales del siglo XIX y principios del XX, y a las transformaciones en la técnica, aparecieron inmigrantes, intuitivos, emprendedores y que buscando un rédito comercial irían construyendo el mercado de entretenimientos de la Argentina.El presente trabajo intentará dar cuenta de los primeros pasos de Glücksmann, uno de estos inmigrantes, como empleado de la Casa de fotografía Lapage que se encontraba en el centro de la ciudad de Buenos Aires, para luego pasar a ser su gerente y culminar como dueño de la misma. Y transformarse desde este espacio con el correr del siglo XX en uno de los hacedores de la cinematografía y de la industria del disco en la Argentina. Para esto haremos un recorrido por fuentes gráficas de la época intentando realizar una reconstrucción del entramado del circuito cultural por donde se desenvolvía. Como también, observar el crecimiento de la ciudad, los habitantes que empiezan a circular y que aparecen como posibles consumidores de diferentes productos. A partir de la observación de los métodos de comercialización, como por ejemplo la publicidad, y del análisis de cómo estaba organizada la Casa Lapage distinguiremos el accionar de Max Glücksmann como gerente del comercio y miraremos el itinerario sobre las decisiones que tomaba y como ayudaron a delinear el naciente mercado de entretenimiento de la ciudad de Buenos Aires. DOI: 10.21665/2318-3888.v3n6p115-138
O MISSIONÁRIO E O CORONEL: UMA ICONOGRAFIA DO MÉDICO-MISSIONÁRIO GEORGE BUTLER
Authors: Veras Rogério de Carvalho 
Published: June 2016

Empreendemos um estudo sobre a inserção do protestantismo no Nordeste do Brasil por meio da biografia do médico e missionário protestante George William Butler. No âmbito de uma perspectiva micro-analítica, objetivamos compreender como ele dá sentido às suas relações sociais e ao mundo à sua volta – o Nordeste no alvorecer do século XX – bem como essa sociedade recepcionou um indivíduo portador de uma nova religiosidade. Percebendo as limitações das fontes escritas (relatórios missionários) para tais propósitos de pesquisa, buscamos uma análise iconográfica das fotos divulgadas pelo missionário e sua esposa, por meio de sua instituição: a Presbyterian Church in the United States (PCUS). Pensamos essas imagens como uma via de acesso às representações sociais que cercam as relações entre um protestante, originário do sul dos Estados Unidos, e a cultura local, por meio da investigação da produção, circulação e apropriação dessas imagens. As fotografias, cotejadas com outras fontes escritas, permitiram-nos recompor a dimensão ideológica das imagens e o esforço de manutenção do poder, em meio aos avanços e recuos da transição secularizadora e do capitalismo anglo-saxão, aliando protestantes e latifundiários, no interior pernambucano. DOI: 10.21665/2318-3888.v3n6p169-190
Reliability and Validity of Electro-Goniometric Range of Motion Measurements in Patients with Hand and Wrist Limitations
Authors: Bashardoust Tajali Siamak , MacDermid Joy C. , Grewal Ruby , Young Chris 
Published: June 2016

Study Design:
Cross-sectional reliability and validity study.

Purpose:
1. To determine intrarater, interrater and inter instrument reliabilities and validity of two digital electro goniometry to measure active wrist/finger range of motions (ROMs) in patients with limited motion. 2. To determine intrarater and interrater reliabilities of digital goniometry to measure torques of PIP passive flexion of the index finger in patients with limited motion.

Methods:
The study was designed in a randomized block plan on 44 patients (24 women, 20 men) with limited wrist or hand motions. Two experienced raters measured active wrist ROMs, and active and passive index PIP flexion using two digital goniometers. All measures were repeated by one rater 2-5 days after the initial measurements. The reliability measures were analyzed using Intraclass Correlation Coefficients (ICCs) and the construct validity was determined by correlation coefficients analysis between sub measures of scores; patient rated pain and function (PRWE) and quick Disabilities of the Arm, Shoulder and Hand (quick DASH) scores.

Results:
The intrarater, interrater and inter instrument reliabilities were high in most ROM measures (range 0.64-0.97) for both types of electro-goniometers. The 95% limit of agreements and Bland and Altman plots did not show progressive changes. There was a significant difference in force application between the raters when performing passive ROM measures for PIP index, but the same rater produced consistent force. Most of the NK and J-Tech ROM measures were moderately correlated with the patient rated pain and function scores (range 0.32-0.63).
MOJAVE. XIII. PARSEC-SCALE AGN JET KINEMATICS ANALYSIS BASED ON 19 YEARS OF VLBA OBSERVATIONS AT 15 GHz
Authors: Lister M. L. , Aller M. F. , Aller H. D. , Homan D. C. , Kellermann K. I. , Kovalev Y. Y. , Pushkarev A. B. , Richards J. L. , Ros E. , Savolainen T. 
Published: June 2016

ABSTRACT
We present 1625 new 15 GHz (2 cm) VLBA images of 295 jets associated with active galactic nuclei (AGNs) from the MOJAVE and 2 cm VLBA surveys, spanning observations between 1994 August 31 and 2013 August 20. For 274 AGNs with at least 5 VLBA epochs, we have analyzed the kinematics of 961 individual bright features in their parsec-scale jets. A total of 122 of these jets have not been previously analyzed by the MOJAVE program. In the case of 451 jet features that had at least 10 epochs, we also examined their kinematics for possible accelerations. At least half of the well-sampled features have non-radial and/or accelerating trajectories, indicating that non-ballistic motion is common in AGN jets. Since it is impossible to extrapolate any accelerations that occurred before our monitoring period, we could only determine reliable ejection dates for

of those features that had significant proper motions. The distribution of maximum apparent jet speeds in all 295 AGNs measured by our program to date is peaked below

, with very few jets with apparent speeds above

. The fastest speed in our survey is

, measured in the jet of the quasar PKS 0805−07, and is indicative of a maximum jet Lorentz factor of ∼50 in the parent population. An envelope in the maximum jet speed versus redshift distribution of our sample provides additional evidence of this upper limit to the speeds of radio-emitting regions in parsec-scale AGN jets. The Fermi-LAT-detected gamma-ray AGNs in our sample have, on average, higher jet speeds than non-LAT-detected AGNs, indicating a strong correlation between parsec-scale jet speed and the gamma-ray Doppler boosting factor. We have identified 11 moderate-redshift (

) AGNs with fast apparent speeds (

) that are strong candidates for future TeV gamma-ray detection. Of the five gamma-ray loud narrow-lined Seyfert I AGNs in our sample, three show highly superluminal jet motions, while the others have sub-luminal speeds. This indicates that some narrow-lined Seyfert I AGNs possess powerful jets with Lorentz factors in excess of 10, and viewing angles less than

, consistent with those of typical BL Lac objects and flat-spectrum radio quasars.