bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Barcelona Hospital Clínic therapeutic apheresis database
Authors: Cid Joan , Carbassé Gloria , Cid‐Caballero Marc , López‐Púa Yolanda , Alba Cristina , Perea Dolores , Lozano Miguel 
Published: September 2017

IntroductionA therapeutic apheresis (TA) database helps to increase knowledge about indications and type of apheresis procedures that are performed in clinical practice. The objective of the present report was to describe the type and number of TA procedures that were performed at our institution in a 10‐year period, from 2007 to 2016.Material and methodsThe TA electronic database was created by transferring patient data from electronic medical records and consultation forms into a Microsoft Access database developed exclusively for this purpose. Since 2007, prospective data from every TA procedure were entered in the database.ResultsA total of 5940 TA procedures were performed: 3762 (63.3%) plasma exchange (PE) procedures, 1096 (18.5%) hematopoietic progenitor cell (HPC) collections, and 1082 (18.2%) TA procedures other than PEs and HPC collections. The overall trend for the time‐period was progressive increase in total number of TA procedures performed each year (from 483 TA procedures in 2007 to 822 in 2016). The tracking trend of each procedure during the 10‐year period was different: the number of PE and other type of TA procedures increased 22% and 2818%, respectively, and the number of HPC collections decreased 28%.ConclusionThe TA database helped us to increase our knowledge about various indications and type of TA procedures that were performed in our current practice. We also believe that this database could serve as a model that other institutions can use to track service metrics.
Comparing leukapheresis protocols for an AML patient with symptomatic leukostasis
Authors: Cline Abigail , Jajosky Ryan , Shikle James , Bollag Roni 
Published: September 2017

BackgroundAcute myeloid leukemia (AML) is a malignancy characterized by rapid clonal proliferation of myeloid precursors, which can result in hyperleukocytosis. Leukapheresis can be used to rapidly reduce the white blood cell count (WBC). However, the only FDA cleared device for WBC depletion, the COBE Spectra, will no longer be supported by the manufacturer in 2017, and there are few studies comparing different methods of leukapheresis.Case reportA 68‐year‐old African American female was admitted to the hospital for relapse of her AML. Laboratory data demonstrated a WBC count of 291 600/μL and flow cytometry of the peripheral blood demonstrated 85% myeloid blasts. Leukapheresis was ordered to help treat the leukostasis.MethodsThree different apheresis protocols were used to achieve cytoreduction: Spectra Optia mononuclear collection (MNC) protocol, Spectra Optia granulocyte collection (PMN) protocol, and Therakos CELLEX buffy coat collection without return. Due to different inlet flow rates, the procedures were evaluated based on the number of WBCs collected and volume of blood processed (VBP).ResultsThe Spectra Optia PMN collected the most WBCs and collected nearly as many WBCs per VBP as the Therakos CELLEX, which had the highest value.ConclusionTo our knowledge, we are reporting the first use of Therakos CELLEX and Spectra Optia PMN protocol for WBC depletion. While the Spectra Optia granulocyte protocol showed the best performance for this AML patient, further studies will be needed to compare the Spectra Optia PMN protocol to the MNC protocol for AML patients.
Evaluation of a newly developed chemiluminescence immunoassay for detecting cardiac troponin T
Authors: Wang Jingkun , Fang Yizhen , Li Peihua , Lin Huayue , Jin Hongwei , Gao Lei , Ge Shengxiang , Zhang Zhong‐Ying 
Published: September 2017

BackgroundTo evaluate the performance of a chemiluminescence detection kit for cardiac troponin T (cTnT).MethodsAccording to the “Guiding principles on performance analysis of diagnostic reagents in vitro” and the Clinical and Laboratory Standards Institute (CLSI) Guidelines, we assessed the detection limit, linear range, reportable range, accuracy, precision, cross reactivity, interference factors, and matrix effect of the kit, and compared these parameters with that of the commercial electrochemiluminescence detection kit for cTnT (Roche).ResultsThe minimum detection limit of the kit was 0.01 ng/mL. The linear range was 0.01 ng/mL‐25 ng/mL. The reportable range was from 0.01 ng/mL to 100 ng/mL. Precision within the batch was 2.9%‐6.4%, and precision between batches was 6.0%; the accuracy was good and the recovery rate reached 96.2%. The cross‐reaction test demonstrated that there was no reactivity between cTnT and a variety of troponins. Test results deviated by less than ±10% in the presence of hemoglobin ≤1000 μg/mL, bilirubin ≤250 μg/mL, triglycerides ≤11.25 mg/mL, and rheumatoid factor ≤206 U/mL, suggesting that kit results were not significantly interfered with these factors. Results from the matrix‐effect assessment revealed absence of a matrix effect in the tested serum samples. Correlation study revealed that the performance of the kit was very consistent with that of the Roche electrochemiluminescence detection kit (Kappa = 0.900, P < .001) with a high correlation (r = .903, P < .001) and a total matching rate of 95.00%.ConclusionThe performance of the evaluated chemiluminescence immunoquantitation kit for cTnT detection was acceptable in all tested parameters, fulfilling requirements for clinical applications.
Repeated‐Dose Oral N‐Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress
Authors: Coles Lisa D. , Tuite Paul J. , Öz Gülin , Mishra Usha R. , Kartha Reena V. , Sullivan Kathleen M. , Cloyd James C. , Terpstra Melissa 
Published: September 2017

AbstractParkinson's disease (PD) is associated with oxidative stress and decreased nigral glutathione (GSH), suggesting that therapies that boost GSH may have a disease‐modifying effect. Intravenous administration of a high dose of N‐acetylcysteine (NAC), a well‐known antioxidant and GSH precursor, increases blood and brain GSH in individuals with PD and with Gaucher disease and in healthy controls. To characterize the pharmacokinetics of repeated high oral doses of NAC and their effect on brain and blood oxidative stress measures, we conducted a 4‐week open‐label prospective study of oral NAC in individuals with PD (n = 5) and in healthy controls (n = 3). Brain GSH was measured in the occipital cortex using 1H‐MRS at 3 and 7 tesla before and after 28 days of 6000 mg NAC/day. Blood was collected prior to dosing and at predetermined collection times before and after the last dose to assess NAC, cysteine, GSH, catalase, malondialdehyde (MDA) and 4‐hydroxynonenal (4‐HNE) concentrations and the reduced‐to‐oxidized GSH ratio (GSH/ glutathione disulfide [GSSG]). Symptomatic adverse events were reported by 3 of the 5 subjects with PD. NAC plasma concentration–time profiles were described by a first‐order absorption, 1‐compartment pharmacokinetic model. Although peripheral antioxidant measures (catalase and GSH/GSSG) increased significantly relative to baseline, indicators of oxidative damage, that is, measures of lipid peroxidation (4‐HNE and MDA) were unchanged. There were no significant increases in brain GSH, which may be related to low oral NAC bioavailability and small fractional GSH/GSSG blood responses. Additional studies are needed to further characterize side effects and explore the differential effects of NAC on measures of antioxidant defense and oxidative damage.
Retraction: Association Between 5‐HTR2C –759C/T (rs3813929) and –697G/C (rs518147) Gene Polymorphisms and Risperidone‐Induced Insulin Resistance Syndrome in an Indian Population
Authors: Das Saibal , Dey Jayanta Kumar , Prabhu Niranjan , David Sachin , Kumar Aniket , Braganza Deepa , Shanthi Margaret 
Published: September 2017

AbstractThe above article from the Journal of Clinical Pharmacology, first published online on 22 September 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement among the authors, the journal Editor in Chief, Joseph Bertino, and Wiley Periodicals, Inc. The retraction has been agreed upon due to the article having been submitted by the lead author without agreement from all co‐authors. Having been alerted to this irregularity, the journal was also advised by the Senior Author of inaccuracies in the genotyping data.ReferenceDas, S., Dey, J. K., Prabhu SS, N., David, S., Kumar, A., Braganza, D. and Shanthi FX, M. (2017), Association Between 5‐HTR2C –759C/T (rs3813929) and –697G/C (rs518147) Gene Polymorphisms and Risperidone‐Induced Insulin Resistance Syndrome in an Indian Population. The Journal of Clinical Pharmacology. doi:10.1002/jcph.1012
Improvement of the bioelectrochemical hydrogen production from food waste fermentation effluent using a novel start‐up strategy
Authors: Cardeña René , Moreno‐Andrade Iván , Buitrón Germán 
Published: September 2017

AbstractBACKGROUNDFood waste is a valuable source of hydrogen by dark fermentation. Dark fermentation effluent contains volatile fatty acids that can be further converted into more hydrogen using microbial electrolysis cells (MECs). In this process, the anodic potential (Ean) has a significant influence on the MEC performance as well as the effluent composition. The objective of this study was to evaluate the effects of variation of the anode potential and substrate composition (food waste fermentation effluent) on the performance of hydrogen production using two‐chamber MECs.RESULTSColonization was conducted using an Ean of 0.5 V vs Ag/AgCl. After 38 days, the Ean had decreased to 0.3 V, resulting in an increase in the hydrogen production rate (from 287 to 482 mL H2 L‐1cat d‐1). A maximum hydrogen production rate of 685 mL H2 L‐1cat d‐1 was observed when effluent that contained the highest acetate concentration was utilized. Cathodic hydrogen recovery was higher than 93%, and hydrogen yield was greater than 873 mL H2 g‐1 COD.CONCLUSIONThe start‐up strategy in which Ean is decreased after the formation of an electroactive biofilm resulted in increased hydrogen production. The composition of the food waste fermented effluent influences the hydrogen production rate. © 2017 Society of Chemical Industry
An Evaluation Toolkit for Small NGOs in Water‐based Development
Authors: Lu Stephanie K. , Elliott Susan J. , Majowicz Shannon E. , Perlman Christopher M. 
Published: September 2017

AbstractSmall NGOs in international development have a unique advantage when it comes to engaging communities, establishing partnerships and advocating rights. However, studies suggest that small NGOs are disadvantaged when it comes to demonstrating evidence‐based impact. Small NGOs are less likely to invest in development evaluation as they lack expertise and/or feel strongly about funding programmes and not processes, given the increased demand for accountability to donors. To explore the challenge NGOs face in moving from a single project‐based entity to a vision‐led professional entity, we have documented the creation of low‐cost evaluation tools using a case study in water‐based development. Copyright © 2017 John Wiley & Sons, Ltd.
Screening of exon methylation biomarkers for colorectal cancer via LC‐MS/MS strategy
Authors: Huang Qionglin , Yang Qingjin , Mo Mingming , Ye Xiaoxia , Zhang Junjie , Zhang Lijian , Chen Bin , Li Jian , Cai Chun 
Published: September 2017

AbstractThe identification of biomarkers would be of benefit for the diagnosis and treatment of colorectal cancer. DNA methylation in specific genomic regions, which had shown strongly association with disease genotypes, was an effective indicator to reveal the occurrence and development of cancers. To screen out methylation biomarkers for colorectal cancer (CRC), genomic DNA was isolated from colorectal cancerous and corresponding cancer‐adjacent tissues collected from 30 CRC patients and then bisulfite‐converted. The exon regions of 5 targeted genes (CNRIP1, HIC1, RUNX3, p15, and SFRP2) were amplified by using nested polymerase chain reaction with specific primers, and the amplicon was purified and hydrolyzed. The methylation levels of these specific regions were detected by liquid chromatography tandem mass spectrometry (LC‐MS/MS). The results showed that 5 targeted exon regions were successfully amplified and confirmed by sequencing. The methodological validations indicated that LC‐MS/MS was highly sensitive and accurate. The methylation levels of CNRIP1 and RUNX3 were remarkably high in CRC tissues with statistical difference when compared with corresponding cancer‐adjacent individuals, while that of HIC1, p15, and SFRP2 had no difference between 2 subjects. These findings supported CNRIP1 and RUNX3 as potential DNA methylation biomarkers for CRC diagnosis and treatment, and our LC‐MS/MS approach exhibited great advantages in the identification of regional DNA methylation biomarkers.
Vegetation response to abrupt climate changes in Western Europe from 45 to 14.7k cal a BP: the Bergsee lacustrine record (Black Forest, Germany)
Authors: Duprat‐Oualid Fanny , Rius Damien , Bégeot Carole , Magny Michel , Millet Laurent , Wulf Sabine , Appelt Oona 
Published: September 2017

ABSTRACTBetween 45 and 14.7k cal a BP, the North Atlantic climate was characterized by a succession of short‐lived Greenland Stadials (GS)/Interstadials (GI), which impacted terrestrial environments. We present a new pollen record from the Bergsee (47°34′20″N, 7°56′11″E), which was ice free during the Last Glacial. We constructed a robust chronology for the period 45–14.7k cal a BP based on 14 accelerator mass spectrometry radiocarbon dates and a tephra attributed to the Laacher See Tephra. Vegetation history was reconstructed at the sub‐millennial scale using pollen analysis. At millennial timescale, a 45–30k cal a BP period shows relatively high tree percentages and marked forest developments, consistent with warmer and more humid conditions during Marine Isotope Stage (MIS) 3. This contrasts with a 30–14.7k cal a BP period of steppe conditions, favoured by a colder/more arid MIS 2. In detail, vegetation seems to respond to GIs and GSs with the successive development of steppes and boreal forests. The impact of Heinrich events is also recorded with a marked development of Artemisia. Comparison with European records shows the contribution of the Bergsee pollen record to understanding impacts of the North Atlantic climate variability on landscapes across longitudinal and latitudinal gradients.
Fortified tuna bone powder supplementation increases bone mineral density of lactating rats and their offspring
Authors: Suntornsaratoon Panan , Charoenphandhu Narattaphol , Krishnamra Nateetip 
Published: September 2017

AbstractBACKGROUNDBreastfeeding leads to bone calcium loss for milk production, resulting in progressive maternal osteopenia. Calcium supplement from natural sources has been postulated to be more beneficial to bone health than purified CaCO3 because natural sources also contain other nutrients such as certain amino acids that might enhance calcium metabolism. Herein, we examined the effect of calcium supplementation from tuna bone powder and CaCO3 on bones of dams and the offspring.RESULTSBoth forms of calcium supplement, i.e. tuna bone powder and CaCO3, increased maternal bone mineral density (BMD). However, bone histomorphometry revealed that only tuna bone had beneficial effect on maternal bone microstructure, i.e. increased bone formation, decreased bone resorption and increased in bone volume. Regarding the mechanical properties, the decreased ultimate load in non‐supplement lactating mothers was restored to the load seen in nulliparous animals by calcium supplementation. Moreover, both tuna bone and CaCO3 supplementation in mothers led to increased milk calcium concentration and consequently increased BMD in the growing offspring.CONCLUSIONCalcium supplement from tuna bone powder was effective in preventing maternal osteopenia. Tuna bone, which is a readily available fishing industrial waste, is a good alternative source of calcium supplement that increases BMD in both lactating mothers and the neonates. © 2017 Society of Chemical Industry
Distribution network management under electricity deregulation using evolutionary many‐objective optimization
Authors: Sekizaki Shinya , Nishizaki Ichiro , Hayashida Tomohiro 
Published: September 2017

AbstractA distribution network operator can reconfigure the network topology by operating section switches to improve multiple objective functions, that is, the line losses and the lifespan of transformers. In the context of long term network management, the impact of future electricity deregulation should be taken into account. Because the related literature has not addressed the above problems, this paper presents a multicriteria optimization approach for efficient distribution network management under electricity market deregulation. The main contributions of this paper can be summarized as follows: (a) the time‐variable (time dependent) and nonconvex issues for the distribution network management are formulated such that the time series variations of the line losses and the transformers mechanical operations are modelled, (b) an electricity consumption model under the deregulation, in which consumers flexibly respond to electricity prices, is taken into account, and (c) from the practical viewpoint, the proposed evolutionary many‐objective optimization approach is applied to find approximated Pareto optimal solutions of the nonconvex large‐scale problem within practical operating time. It can be seen from the computational experiment that the proposed method enables the network operator to easily identify a better network topology, which adequately meets the multiple requirements of the operator.
Progression of MDS‐UPDRS Scores Over Five Years in De Novo Parkinson Disease from the Parkinson's Progression Markers Initiative Cohort
Authors: Holden Samantha K. , Finseth Taylor , Sillau Stefan H. , Berman Brian D. 
Published: September 2017

AbstractBackgroundThe Movement Disorder Society‐Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) is a commonly used tool to measure progression in patients with Parkinson's disease (PD). Longitudinal changes in MDS‐UPDRS scores in patients with de novo PD have not been established. The objective of this study was to determine progression rates of MDS‐UPDRS scores in de novo PD.MethodsIn total, 362 participants from the Parkinson's Progression Markers Initiative, a multicenter, longitudinal cohort study of de novo PD, were included. Longitudinal progression of MDS‐UPDRS total and subscale scores were modeled using mixed model regression.ResultsMDS‐UPDRS scores increased in a linear fashion over 5 years in patients with de novo PD. MDS‐UPDRS total scores increased an estimated 4.7 points per year, Part I scores increased 0.92 points per year, Part II scores increased 0.99 points per year, and Part III scores increased 2.4 points per year.ConclusionsThe expected average progression of MDS‐UPDRS scores in patients with de novo PD from this study can assist in clinical monitoring and provide comparative data for the detection of disease modification in treatment trials.
Quasi‐planar substrate integrated waveguide pyramidal horn antenna for Ku‐band applications
Authors: Ashraf Syed Ali , Singh Soni , Sahu Bhagirath , Singh S. P. 
Published: September 2017

AbstractIn this paper, a novel quasi‐planar substrate integrated waveguide (SIW) pyramidal horn antenna for Ku‐band applications is presented. The proposed antenna provides wider multiple frequency sub‐bands in Ku‐band and improved E‐plane half power beamwidth. Although the proposed design affects the planarity of the antenna to some extent but by and large it maintains the compactness of the antenna. In addition, the proposed horn is easy to fabricate and preserves two most important characteristics of SIW technology, namely compactness and easy manufacturing. Dimension optimization of the antenna and simulation studies of its input and radiation characteristics were performed using Ansys HFSS software. Further, a prototype of the proposed antenna was fabricated on FR4 substrate of dimensions 35 mm × 35 mm × 3.2 mm and antenna characteristics were determined experimentally. It is found that simulated antenna characteristics are nearly in agreement with the corresponding experimental ones, which verify the proposed antenna concept.
Design of inverse Class‐F power amplifier based on dual transmission line with 87.4% drain efficiency
Authors: Huang Hang , Zhang Bo , Yu Cuiping , Gao Jinchun , Wu Yongle , Liu Yuanan 
Published: September 2017

AbstractIn this paper, an inverse Class‐F power amplifier (PA) based on dual transmission line (DTL) is presented. The output matching network (OMN) with DTL has a simple and compact circuit topology compared with other harmonic‐tuned OMNs with open/short shunt stubs and provides up to 6th harmonic suppression. In addition, the DTL structure is equivalent to a quarter wavelength transformer for fundamental matching. A GaN HEMT is adopted to achieve high output power and high drain efficiency in the proposed inverse Class‐F PA. Finally, a 2.4 GHz inverse Class‐F PA is designed and fabricated. The experimental results show the highest drain efficiency of 87.4% in the operating frequency with the corresponding output power of 44.5 dBm, and adjacent channel power ratio (ACPR) of −50.8/‐51.6 dBc with digital predistortion technique (DPD) at 2.4 GHz.
A phase correction technique based on spatial movements of antennas in real‐time for designing self‐adapting conformal array antennas
Authors: Roy Sayan , Sajal Sayeed , Braaten Benjamin D. 
Published: September 2017

AbstractThis article presents a real‐time adaptive phase correction technique for flexible phased array antennas on conformal surfaces of variable shapes. Previously reported pattern correctional methods for flexible phased array antennas require prior knowledge on the possible non‐planar shapes in which the array may adapt for conformal applications. For the first time, this initial requirement of shape curvature knowledge is no longer needed and the instantaneous information on the relative location of array elements is used here for developing a geometrical model based on a set of Bézier curves. Specifically, by using an array of inclinometer sensors and an adaptive phase‐correctional algorithm, it has been shown that the proposed geometrical model can successfully predict different conformal orientations of a 1‐by‐4 array antenna in real‐time without the requirement of knowing the shape‐changing characteristics of the surface the array is attached upon. Moreover, the phase correction technique is validated by determining the field patterns and broadside gain of the 1‐by‐4 array antenna on 4 different conformal surfaces with multiple points of curvatures. Throughout this work, measurements are shown to agree with the analytical solutions and full‐wave simulations.
Three‐dimensional‐printed tapered cavity‐backed flush‐mountable wideband antenna for UAV
Authors: Lee Seongkyu , Jeoung Guho , Choi Jaehoon 
Published: September 2017

AbstractA 3D‐printed tapered cavity‐backed flush‐mountable wideband antenna for UAV applications is proposed. The antenna consists of a mono‐cone and an exponentially tapered cavity, which are fabricated using 3D printing technology. Performance degradation caused by the resonance of a conventional cavity is reduced by tapering the cavity. The antenna has the overall dimensions of 224 mm × 224 mm × 34 mm. The measured 10‐dB return loss bandwidth of the antenna is 24.4 GHz ranging from 1.3 GHz to 25.7 GHz (180%). The measured radiation pattern has an omnidirectional characteristic over the operating frequency band.