bluuebunny/crossref_metadata_2025_split huggingface dataset:
An experience of therapy with nintedanib in patients with idiopathic pulmonary fibrosis
Authors: Akhmedov V. A. , Petrov D. V. , Gaus O. V. , Ovsyannikov N. V. , Kochetov A. M. , Mashurov M. V. , Moiseenko F. P. 
Published: May 2017

Idiopathic pulmonary fibrosis (IPF) is the most common clinical variant of idiopathic interstitial pneumonia. Pathophysiology of IPF involves recurrent damage of the alveolar epithelium with fibroblast excessive proliferation as aberrant reparative activity of the lung interstitium. Currently, a treatment approach to this disease has been revised. Given new knowledge on pathogenesis of IPF, an international evidencebased clinical guideline published in 2015 recommends antifibrotic agents as the basic therapy of IPF. The only antifibrotic agent registered in Russia is niintedanib. A clinical case of IPF with the first experience of therapy with nintedanib in Omsk region has been reported in the article.
A comparative study of pulmonary function between smokers and nonsmokers of rural population of Katihar, Bihar, India
Authors: Kumar Rakesh , Suman Shanker 
Published: May 2017

Background: In India, where majority of the population lives by agriculture and linked occupations in rural areas despite of rapid increase in urban population, the pulmonary function is expected to vary between smokers and non-smokers.Methods: This study was carried out in the rural population of Katihar, Bihar in 100 participants. Prior consent was obtained from the Ethical committee for the study. Computerized spirometer RMS Helios 701 was used for the study.Results: This study was done for a better understanding of effects of smoking in the rural population of Katihar. In rural non-smokers, the observed value of pulmonary functions in mean±standard deviation, FVC was 3.28±1.04 litres, FEV1 was 2.72±0.97 litres, FEV1% was 85.24±28.24, PEFR was 7.8±1.98 litres/minute, FEF25-75% was 4.28±0.99 litres. The observed value of pulmonary functions in rural smoker population in mean±standard deviation, FVC was 2.56±0.86 litres, FEV1 was 2.21±0.96 litres, FEV1% was 86.00±23.73, PEFR was 5.65±2.18 litres/minute, FEF25-75% was 3.34±1.37 litres.Conclusions: The comparative study of pulmonary function between rural smokers and rural non-smokers showed significant decreased value (p value < 0.05) in smokers of rural population.
Mulheres Negras e a Discussão de Gênero na Construção das Narrativas nos Museus de Salvador
Authors: Flores Silva Joana Angélica 
Published: May 2017

O artigo trata da representação das mulheres negras nos museus históricos de Salvador, a partir dos vieses em gênero, raça e classe ao analisar o lugar que as mesmas ocupam nas exposições de longa duração, levando em consideração a teia de relações estabelecidas na tríade HomemXObjetoXRealidade. A abordagem se debruça sobre o discurso construído pelos museus ao atribuir à mulher branca o papel de protagonista na historiografia do país, enquanto que concede a figura da escravizada à mulher negra nesse mesmo contexto histórico, o que retroalimenta o imaginário coletivo quando lhe outorga a condição de subalterna. Com base na práxis museológica, a pesquisa deter-se-á no âmbito da reinterpretação dos signos, no processo de musealização dos objetos que representam o universo feminino. Assim, o estudo traz como contribuição, a reflexão acerca da construção de novas narrativas que evidenciem de forma não discriminatória a participação dos sujeitos nos espaços de memória.
Palavras-Chave: Museus de Salvador; Museologia; Gênero; Mulheres negras; Representações

ABSTRACT

The article deals this the representation of black women in the historical museums of Salvador, starting in the gender, race and class. Analyzing the place they occupy in long - term exhibit, taking into account of relationships established in the triad Man x Object x Reality. The approach focuses on the discourse constructed by the museums in assigning the white woman the role of protagonist in the historiography of the country, while granting the figure of the enslaved to the black woman, in this same historical context, which feeds the collective imaginary when it grantates the subordinate condition. Based on the museological praxis, the research will focus on the reinterpretation of signs, in the process of musealization of objects that represent the feminine universe. Therefore, this article bring forward a contribution, the reflection about the construction of new narratives that evidence in a non-discriminatory way the participation of the subjects in the memory spaces.
Keywords: Museums of Salvador; Museology; Genre; Black Women; Representations
Quantitative Structure – Pharmacokinetic Relationships for Plasma Clearance of Basic Drugs with Consideration of the Major Elimination Pathway
Authors: Zhivkova Zvetanka Dobreva 
Published: May 2017

Purpose. The success of a new drug candidate is determined not only by its efficacy and safety, but also by proper pharmacokinetic behavior. The early prediction of pharmacokinetic parameters could save time and resources and accelerate drug development process. Plasma clearance (CL) is one of the key determinants of drug dosing regimen. The aim of the study is development of quantitative structure – pharmacokinetics relationships (QSPkRs) for the CL. Methods. A dataset consisted of 263 basic drugs, which chemical structures were described by 154 descriptors. Genetic algorithm, stepwise regression and multiple linear regression were used for variable selection and model development. Predictive ability of the models was assessed by internal and external validation. Results. A number of significant QSPkR models for the CL were derived with respect to the primary elimination pathway (renal excretion, metabolism, or CYP3A4 mediated biotransformation), as well for the unbound clearance (CLu). The models were able to predict 52 – 80% of the drugs from external validation sets within the 2-fold error of the experimental values with geometric mean fold error 1.57 – 2.00. Conclusions. Plasma protein binding was the major restrictive factor for the CL of drugs, primarily cleared by metabolism. The clearance was favored by lipophilicity and several structural features like OH-groups, aromatic rings, large hydrophobic centers, aliphatic groups, connected with electro-negative atoms, and non-substituted aromatic C-atoms. The presence of Cl-atoms and abundance of 6-member aromatic rings or fused rings had negative effect. The presence of ether O-atoms contributed negatively to the CL of both metabolism and renally excreted drugs, and urine excretion was favored by the presence of 3-valence N-atoms. These findings give insight on the main structural features governing plasma CL of basic drugs and could serve as a guide for lead optimization in the drug development process. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
A Super (A,D)-Bm-Antimagic Total Covering of Ageneralized Amalgamation of Fan Graphs
Authors: Agustin Ika Hesti , Dafik Dafik , Latifah Siti , Prihandini Rafiantika Megahnia 
Published: May 2017

All graph in this paper are finite, simple and undirected. Let G, H be two graphs. A graph G is said to be an (a,d)-H-antimagic total graph if there exist a bijective function such that for all subgraphs H’ isomorphic to H, the total H-weights form an arithmetic progression where a, d 0 are integers and m is the number of all subgraphs H’ isomorphic to H. An (a, d)-H-antimagic total labeling f is called super if the smallest labels appear in the vertices. In this paper, we will study a super (a, d)-Bm-antimagicness of a connected and disconnected generalized amalgamation of fan graphs on which a path is a terminal.
Almost Surjective Epsilon-Isometry in The Reflexive Banach Spaces
Authors: Rohman Minanur 
Published: May 2017

In this paper, we will discuss some applications of almost surjective epsilon-isometry mapping, one of them is in Lorentz space ( L_(p,q)-space). Furthermore, using some classical theorems of w star-topology and concept of closed subspace -complemented, for every almost surjective epsilon-isometry mapping f : X to Y, where Y is a reflexive Banach space, then there exists a bounded linear operator T : Y to X with such that for every x in X.
INFLUENCE OF JAMU MADURA “EMPOT SUPER” ON THE VAGINAL EPITHELIUM THICKNESS OF WHITE MICE (Rattus norvegicus) – AN IN VIVO STUDY
Authors: Listiyana Anik 
Published: May 2017

<p><em>The aim of this research is to determine the influence of jamu Madura “Empot Super” (JMES) on the vaginal epithelium thickness of Rattus norvegicus in vivo. This research is kind of “true experimental-post test only control group design”. The rats were given drinking JMES once daily PS (Per-Sonde) for a month, then the vagina was taken to be sample for HE colouring. The sample was observed by the binocular microscope (100 times magnification) to identify the changes in the thickness of their vaginal epithelium. Calculation of the vaginal epithelium thickness was counted on the 10 field of view chosen randomly by the blind method. The result show that the vaginal epithelium thickness increased with dose 0,17mg/BW, 0,34mg/BW, and 0,68mg/BW of JMES compared with negative control group. But, the vaginal epithelium thickness decrease at the dose 0,51mg/BW compared with negative control group.</em></p><p> </p><p><strong>Keywords</strong><strong>: </strong>Jamu Madura “Empot Super” (JMES), vaginal epithelium thickness, white mice (<em>Rattus norvegicus</em>), In Vivo study</p>
Detection of Green Mould Rot Infection of Citrus Fruit by X-ray Scanning Non-Destructive Technology
Authors: Gadgile Dhondiram Panditrao , JOSHI CHANDRAKANT PADMAKAR , SHINDE VIKAS MADHUKARRAO , KACHARE PARSHURAM BABARAO 
Published: May 2017

<p><strong>ABSTRACT</strong> <strong></strong></p><p>Green mould rot is important post-harvest fungal disease of citrus. It is caused by <em>Penicillium digitatum. </em>To study the detection of fungal infection in citrus fruit by X-ray scanning technique<strong>, </strong>the spore suspension of <em>Penicillium </em><em>digitatum </em>was inoculated by sterilized disposable syringe in citrus fruit in aseptic condition. Healthy citrus without inoculation was treated as control. Infection of green mould rot was detected by X-ray scanning nondestructive technology.</p><p><strong>Key words:</strong> <em>Penicillium digitatum</em>, Citrus, X-ray scanning, Post-harvest disease. </p>
Sandro Borelli e a dramaturgia da violência
Authors: Doria Gisela 
Published: May 2017

Esse artigo problematiza aspectos ligados à dramaturgia na dança contemporânea, tendo como eixo três obras do coreógrafo paulista Sandro Borelli. Em seu extenso diálogo com a obra de Kafka, Borelli levou para a cena seis coreografias inspiradas em textos originais. Foi feito um recorte a partir da Trilogia Kafka, composta pelas coreografias inspiradas nas obras homônimas: Metamorfose, Carta ao Pai e O processo.
Tensões entre o não saber, o saber e o fazer no canto cênico
Authors: Chaves Marcos 
Published: May 2017

O presente artigo dialoga sobre a tensão entre o saber e o fazer, a partir do “não saber”, um olhar sobre barreiras encontradas/demonstradas pelos atores na prática do canto em encenações teatrais. Cruzamentos que passam pela educaçãoem nossa cultura, que é visual, observando pontuações de Silvia Davini. Na comunicação, uma visão sobre o processo de criação de espetáculos que compunham a trilogia As Três Batidas de Molière, do grupo Farsa, de Porto Alegre-RS.
Uma escuta sensível: a teatralidade contemporânea na performance O Semeador de Poesias
Authors: Gonçalves Luiz Davi Vieira 
Published: May 2017

O presente artigo visa a apresentar uma investigação desenvolvida dentro do Corpo Cênico: Núcleo de Pesquisa e Experimentações Artísticas, do Centro de EducaçãoProfissional em Artes Basileu França, em Goiânia-GO (CEPABF/GO), intitulada O Semeador de Poesias. A obra surgiu a partir da experiência cênica com o arquétipo da Mandala, com vivências em espaços públicos e reflexões sobre o corpo do ator e suas poéticas.
Driving at Full Employment of Youth of India – Reflecting on Concrete Experience and Abstract Conceptualizing an Action Plan
Authors: Purushothaman P 
Published: May 2017

<div><p><em>The unemployment of youth in India is on the rise. The employability of fresh graduates in India is very low. The general productivity of workforce is also very low. Proper and more interventions, positive actions are required to address the above problems. Solutions may be possible through the four elements of psychological capital development of youth namely, confidence, optimism, perseverance and bouncing back. This paper attempts first mapping the author's own concrete life-long experience with PysCap elements. Then attempting to abstract conceptualizing an action plan, as a learner. This has given some insights, particularly taking the Indian context of spirituality, large population of unemployed youth and how they could be given proper orientation on industry expectation and developing networks through mentors from industry, as one of the best method of effective skill training is by the employer whether formal or informal training, as the industry can not reject the educated youth, after they complete their education. In addition, the paper presents a learner produced integrated PsyCap schematic diagram and recommends an action plan which can be taken up for further participatory-action research. The paper can be used as a case study learning material for development students as this covers developmental psychology, adult education, traditional apprenticeship, gurukula, formal education, distance mode and self directed learning. The positive PsyCap development is not one time exercise, but spreads from young age to old age, as we can not waste the human resources of our country at this critical time of providing and meeting sustainable development goals. </em></p></div>
Need to Restructure Teacher Education in India with reference to Globalization and Localization
Authors: Srivastava Sangeeta , Srivastava P.K. 
Published: May 2017

<div><p><em>Globalization is a feeling that the individual is not only a member of his/her state, but a citizen of the world</em><em> and subsequently teacher education should reflect this global outlook. Now the question arises:</em><em> How teachers' education can be transformed from a traditional country bound training program to a new globalized teachers’ education? </em><em> One of the global challenges which are appearing in this context is to have a gestalt development of any country with all its special cultural identity together with globalization. Only globalization of education is inadequate without localization to pay attention towards the preserving of cultures. It should treat each unique culture and society with due respect, realizing that global education is not only learning about all innovations occurred globally, but also studying different cultures of the world and maintaining them as a cultural heritage of universe. This paper is an attempt to analyze the present position of teacher education in the context of globalization and to explore the need and ways to restructure and redefine teacher education with reference to globalization and localization. It concludes that restructuring teachers' education with reference to globalization and localization is an urgent need so that we may get such teachers who not only will possess world class knowledge but also right attitude to work and live with open mindedness, and will take them forward in global scenario for the welfare of mankind. </em></p></div>
Pradyumnapur: The First Capital of Malla Dynasty: Mallabhum
Authors: Majumder Sukanta 
Published: May 2017

<div><p><em>Nirsinghadev was a great king of Pradyumnapur. In 694 AD (Bengali 101 Abdo), in Indradadashi Tithi, Raghunath’s coronation had done at Pradyumnapur in front of God Indra and Panchanan Ghosal gave him the title as ‘Malla’ and Raghunath was known as Raghunath Malla. From that time started a new era ’Mallabdo’ and Kingdome was known as Mallabhum. After 300 years and eighteen rulers of Mallabhum kingdom, capital was transferred from Pradyumnapur to Bishnupur.</em></p></div>
Problems of North-East People in Metro Cities of India: Need of Human Values for Happy and Healthy Life
Authors: Aamareswaran N. 
Published: May 2017

<div><p><em>In the present liberalized, privatized, globalized, scientific, technological, and digit world the life styles of human beings are changing from time to time. A man need values, principles and culture to become human. The main aim of education is all-round development i.e., physical, mental, spiritual, social, political, technological, and economic development of an individual. Education is a key for development. The people from North-East India in general and tribes in particular are migrating to the metro cities of India for better education, health and employment. Because of their physical features and geographical influence people from North-East India are facing problems at metro cities. Sometimes these problems are diverting or converting into a racial discrimination also. The real citizens of India are not treating as citizens of their own country people. It is a painful and not helpful for national integration. Lack of human values in individual is the only single reason behind these problems. In the present paper an attempt has been made to find the different types of problems and causes of problems. It is also suggested the valuable things to do to solve all types of problems for happy and healthy life. </em></p></div>
A Survey on the Usage of ICT in Pedagogy of Science
Authors: Chakravarty Ritu Tripathi 
Published: May 2017

<div><p><em>Information Communication Technology ICT has impacted the learning world. Educational systems have witnessed changes in the pedagogical approaches with the advent of ICT.</em></p><p><em>The survey of ten science teachers of ten different schools of Lucknow was done to the how ICT is being used as in the classroom pedagogy. The self prepare questionnaire was used. The data was collected from the science teachers. The findings are interesting. It was found that few science subjects the ICT and its applications are used optimally but some others were very less benefited by ICT. The findings also discusses the readiness of the science teachers for the usage of different types of ICT in teaching and management role in engaging and encouraging the opportunities for the usage of ICT in science teachings were explored.</em></p></div>
Student’s Perception towards Subject Teachers: A Contributing Factors for School Attendance
Authors: Chauhan Daxesh S. , Mishra S.D. 
Published: May 2017

<div><p><em>This paper based on study of SMCs’ awareness about Right to Education Act 2009.As per 86<sup>th</sup> amendment of the Indian constitution Right to Education Act 2009 is considered inseparable parts of children’s right. In RTE act there are special provisions for appointment of qualified subject’s teachers, and about pupils’ teachers’ ratio of Primary school. For germination of small plants require sufficient air, water, sunlight &amp; adequate fertilizer without its plant can’t germinate. In same way children also want to germinate and developed themselves so that they can admitted in primary school .Appointment of various subject teacher play a role of fertilizer in germination and development of children. In this study data were collected by means of a questionnaire on SMCs’ members of various primary schools of Anand district and analysed through SPSS using exploratory cum descriptive statistics. Present study found that participants (SMCs’) were neither satisfied nor unsatisfied with appointment of subject teachers and their teaching methods. Chi-square test and karl-pearson correlation helped to find out the relation between the variables. During statistics analysis researcher found very significant relationship between appointment of subject teachers, teachers completed curriculum within specific period, teachers’ motivation and child feel happy to go to schools. </em></p></div>
PREVENTION OF MENINGOCOCCAL INFECTION
Authors: FRIDMAN I. V. , KHARIT S. M. 
Published: May 2017

The article presents data on the relevance of meningococcal infection and the possibility of its prevention by vaccination. Spend a literary analysis of the efficacy and safety of vaccines against meningococcal disease. The results of the epidemiological effectiveness of vaccination at mass use of conjugated vaccines.
ROTAVIRUS INFECTION IN CHILDREN IN THE RF: DIAGNOSTIC AND TREATMENT CHALLENGES TODAY
Authors: BECHTEREVA M. K. , KOMAROVA A. M. , USKOV A. N. 
Published: May 2017

Acute infectious diarrhea in children is a global healthcare challenge [1]. In 2015, the incidence of acute intestinal infections (AII) in the Russian Federation amounted to 545.89 per 100 thousand people; that is almost exactly the same as in 2014. AII of unknown etiology account for 63.44% of cases. There are still significant differences in the effectiveness of the etiological diagnosis of AII in different areas of the Russian Federation. Along with a reduction in the incidence of separate nosologies, the incidence of campylobacteriosis increased by 30.3%, rotavirus by 14% and norovirus by 26.4% [2].
THE ROLE OF LASER DOPPLER FLOWMETRY IN THE STUDY OF SKIN MICROCIRCULATION IN DIFFUSE LIVER DISEASES
Authors: TITARENKO Y. B. , LEVITAN B. N. , SKVORTSOV V. V. 
Published: May 2017

Among the most important links in the pathogenesis of diffuse liver diseases (DLD) are macro- and microhemodynamic disorders that can develop in the liver and in the systemic circulation [2, 3, 7, 12]. Chronic hepatitis (CH) and especially liver cirrhosis (LC) are accompanied by disorders of the portal and systemic circulation, development of portal hypertension which leads to the emergence of portosystemic collaterals and hyperdynamic circulation [2, 3, 7, 12]. The resulting rheological changes in the blood, disorders of systemic hemodynamics run in parallel with the microcirculatory (MC) pathology. [8, 9, 12] In this condition, the inflammatory and reparative processes, maintainance of the adequate level of biochemical reactions in the tissues, cellular functions and changes in blood coagulation system are determined by the microcirculation (MC) status [2, 3, 12].
EFFECTIVE PREVENTION AND TREATMENT OF CHRONIC HEPATITIS B IN THE CONTEMPORARY PRACTICE OF HEPATOLOGY
Authors: MYAZIN R. G. 
Published: May 2017

Modern approaches to the prevention and treatment of chronic hepatitis B are based on the use of vaccination of the population, on the one hand, and rational choice of antiviral therapy schemes in patients - on the other. This allows the physician to predict results of treatment and preventive measures. Modern analogues of nucleosides, in particular, Entecavir, has high efficacy, good tolerance and high safety profile when used in long term conditions.
HIV INTEGRASE INHIBITORS: THE BASIS OF EFFECTIVE AND SAFE ANTIRETROVIRAL THERAPY
Authors: SHAKHGILDYAN V. I. 
Published: May 2017

The article examines the efficacy and safety of HIV integrase inhibitors (raltegravir, dolutegravir) in antiretroviral therapy (ART) regimens in various groups of HIV-infected patients: patients with high HIV RNA blood levels, patients with low CD4-lymphocytes blood count, pregnant women, patients with tuberculosis or chronic hepatitis C, and patients in later years and /or with high cardiovascular risk, neurocognitive disorders. Particular attention is paid to the minimal risk of developing delayed ART complications in using raltegravir in ART regimens and combining raltegravir and drugs of various classes.