bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role Of Upfront Surgery in the Management of Ileal Crohn’s Disease
Authors: Gustavo Kotze Paulo 
Published: September 2024

Crohn's disease (CD) is a chronic inflammatory disorder characterized by transmural inflammation that can affect any part of the gastrointestinal tract. Among the various phenotypes of CD, involvement of the terminal ileum, known as ileal CD, poses unique challenges in management due to its potential for complications such as strictures, fistulas, and abscesses. While medical therapy remains a cornerstone in the management of CD, the role of surgery, particularly upfront surgical intervention (early resection), has garnered increasing attention in recent years.
The decision to pursue surgical intervention at the outset of disease management, rather than relying solely on medical therapy, is a subject of ongoing debate in the field. Upfront surgery (prior to advanced medical therapies) may offer benefits such as rapid resolution of symptoms, avoidance of long-term immunosuppressive therapy and prevention of disease progression. However, concerns regarding the postoperative morbidity and potential for recurrence associated with surgical intervention warrant careful consideration.
Analisis Faktor Yang Mempengaruhi Tingkat Kecemasan Pasien Pre Operasi Di Rumah Sakit Umum Daerah Kabupaten Dompu Tahun 2023
Authors: Mukhlis Mukhlis , Ayatullah Ayatullah , Kadafi Amirul 
Published: September 2024

Anxiety is an emotional reaction that arises from uncertain and non-specific causes that can cause feelings of discomfort and feel threatened. Anxiety causes physical and emotional disturbances, increasing body temperature through hormonal and innervation stimuli. Various causes of anxiety in preoperative patients include situations such as personal, environmental, maturational, educational level, stimulus characteristics, and individual characteristics. The purpose of this study was to determine the factors that affect anxiety in preoperative patients at Dompu Regency Hospital. The research design used non-experimental with analytic survey type and cross-sectional approach. respondents experienced severe anxiety level as many as 4 (6.70%) respondents, moderate anxiety as many as 15 (24.40%) respondents, mild anxiety 28 (46.70%) respondents. The relationship between factors of age, gender, education, marital status, type of surgery, surgical experience is enough to influence respondents in deciding attitudes towards preoperative anxiety. Family support and attention calmed the respondents so that anxiety decreased.
HUBUNGAN TINGKAT PENGETAHUAN PATIENT SAFETY TERHADAP SIKAP PATIENT SAFETY PADA TENAGA KESEHATAN DI RUANG OPERASI RS PKU MUHAMMADIYAH GAMPING
Authors: Firmansyah Riyan , Tri Hapsari Listyaningrum  
Published: September 2024

Keselamatan pasien (patient safety) adalah dasar dari pelayanan kesehatan yang baik. Keselamatan pasien juga menjadi salah satu indikator dalam menilai akreditas institusi pelayanan kesehatan, oleh karena itu keselamatan pasien sangat penting. Namun, jika ditinjau dari insiden keselamatan pasien, keselamatan pasien di berbagai tingkat pelayanan kesehatan masih buruk, baik secara global maupun nasional. Penelitian ini untuk mengetahui Hubungan Tingkat Pengetahuan Patient Safety Terhadap Sikap Patient Safety Pada Tenaga Kesehatan di Ruang Operasi RS PKU Muhammadiyah Gamping. Penelitian ini menggunakan metode kuantitatif dengan desain korelasi, yaitu penelitian hubungan antara dua variabel. Teknik pengambilan sampel menggunakan total sampling, berjumlah 30 responden. Alat yang digunakan dalam pengumpulan data berupa kuesioner analisis data menggunakan uji statistik spearman rank. Penelitian ini menunjukan hasil uji korelasi yang positif hasil uji korelasi yang telah dilakukan, diketahui bahwa nilai signifikansi atau Sig (2-tailed) ialah sebesar 0,000< 0,05 dengan nilai koefisien sebesar 0.711**. Ada hubungan pengetahuan patient safety dengan sikap patient safety pada tenaga kesehatan di ruang operasi RS PKU Muhammadiyah Gamping.
Manajemen Bimbingan Dan Konseling Dalam Meningkatkan Kedisiplinan Siswa Kelas XI Di SMK Terpadu Rangganis
Authors: Sopi Fauziah  
Published: September 2024

Penelitian ini bertujuan untuk menganalisis peran manajemen bimbingan dan konseling dalam meningkatkan kedisiplinan siswa kelas XI di SMK Terpadu Rangganis. Latar belakang penelitian ini adalah rendahnya mutu pendidikan dan daya saing yang masih menjadi perhatian, sehingga diperlukan pendekatan pembelajaran yang lebih efektif dan terarah. Untuk itu, manajemen layanan bimbingan dan konseling menjadi salah satu solusi untuk meningkatkan kualitas belajar siswa. Penelitian ini menggunakan metode deskriptif kualitatif, dengan data dikumpulkan melalui wawancara, observasi, dan dokumentasi. Hasil penelitian menunjukkan bahwa perencanaan bimbingan dan konseling melibatkan penyusunan program kerja yang mencakup strategi, tujuan, struktur, dan mekanisme yang terarah. Dalam pelaksanaan, siswa yang bermasalah mendapatkan layanan bimbingan dari guru BK setelah adanya laporan dari guru atau siswa lain. Siswa kemudian diberi arahan serta diperingatkan untuk tidak mengulangi pelanggaran yang sama, dengan komitmen melalui surat pernyataan. Faktor pendukung yang ditemukan adalah kerja sama antara guru BK, wali kelas, siswa, dan orang tua, serta keterbukaan siswa terhadap guru BK. Sementara itu, faktor penghambat termasuk jarak rumah siswa yang jauh dari sekolah, rendahnya motivasi orang tua dalam menegakkan tata tertib sekolah, dan pengaruh lingkungan yang kurang kondusif. Kesimpulannya, manajemen bimbingan dan konseling di SMK Terpadu Rangganis berhasil membantu meningkatkan kedisiplinan siswa melalui perencanaan dan pelaksanaan program yang matang. Meski terdapat kendala eksternal dan internal, pendekatan yang terarah dan dukungan dari berbagai pihak dapat membantu siswa lebih disiplin dan meningkatkan prestasi akademik.
Self-Consciousness, Couple’s Satisfaction, Maternal-Fetal Attachment and Psychological Distress in Women during Pregnancy
Authors: Shawal Shaud  , Masha Asad Khan  , Tahira Jibeen   
Published: September 2024

Identification of psychological distress, especially in first time pregnant women, is fundamental due to its negative impact on physical and mental health of the mother and the child to be born. The purpose of the present study was to find out the relationship between self-consciousness, couple’s satisfaction, maternal-fetal attachment and psychological distress among first-time pregnant women. The sample (N=100) included first time pregnant women with an age range of 18-37 years (M= 26.23; SD= 3.36) from different hospitals of Lahore, Pakistan. Participants were administered Self Consciousness Scale; The Couple’s Satisfaction Index; Cranley’s Maternal- Fetal Attachment Scale; Kessler Psychological Distress Scale and Demographic Form. The Correlation research design was used. The results of regression analyses revealed that private self-consciousness and social anxiety were positive predictors of psychological distress whereas, public self-consciousness and couple satisfaction emerged to be negative predictors of psychological distress. The current findings have clear implications for mental health practitioners, researchers, and social workers wishing to identify and develop social and clinical therapeutic interventions which enhance positive well-being and decrease psychological distress in pregnant women.
Examining Generation Z Loyalty in Medan's Fashion Sector Omnichannel
Authors: Pasaribu Romindo M , Lubis Arlina Nurbaity , Rini Endang Sulistya , Sembiring Beby Karina F 
Published: September 2024

Generation Z's mobile behavior is a challenge for retailers in the fashion industry to provide and create experiences and engagement that will ultimately form loyalty. create experiences and engagement that will ultimately form customer loyalty. customers. The purpose of this study is to examine and analyze experience, customer engagement, and hedonic cultural value orientation in increasing the loyalty of generation Z customers in Medan City. This research was conducted on Generation Z in Medan City with a sample size of 440 respondents. Data analysis technique data analysis technique using SEM PLS. The results show channel integration, customer experience experience, and customer engagement have a positive and significant effect on customer loyalty variables directly and indirectly. Experience and customer engagement mediate between channel integration and customer loyalty. customer loyalty. Hedonic cultural value orientation is able to strengthen the effect of customer engagement on loyalty but is unable to strengthen the relationship between customer experience and customer loyalty. customer experience and customer loyalty. This research confirms that fashion product retailers should use multiple channels, online and offline, that are well integrated into creating the customer experience. and offline channels that are well integrated in creating customer experience and customer engagement. Information delivered across all channels should be consistent to create a seamless shopping experience online. seamless shopping experience online. Retailers should engage customers by improving communication and providing entertaining services in the form of gamification. Gamification services can create a hedonic culture for Generation Z customers.
Pengaruh Fasilitas dan Lingkungan Kerja Terhadap Kinerja Karyawan Contact Center PT. Rajawali Berdikari Indonesia
Authors: Safitri Wahyuni , Lestari Tri 
Published: September 2024

Penelitian ini dilakukan di PT. Rajawali Berdikari Indonesia yang berpusat di Depok, Jawa Barat, yang mengkhususkan diri pada Business Process Outsourcing (BPO) untuk contact center. Tujuan penelitian adalah untuk menganalisis Pengaruh Fasilitas dan Lingkungan Kerja Terhadap Kinerja karyawan Contact Center di PT. Rajawali Berdikari Indonesia, baik secara individu maupun kolektif. Populasi penelitian berjumlah 57 karyawan, dan jumlah sampel sebanyak 50 orang yang dipilih menggunakan rumus Slovin dengan teknik probabilitas sampling. Analisis data dilakukan dengan menggunakan metode statistik kuantitatif dan diolah dengan software IBM SPSS Statistics V.27. Temuan penelitian menunjukkan bahwa Fasilitas (X1) mempunyai pengaruh positif dan signifikan terhadap kinerja pegawai (Y) jika ditinjau secara independen, sedangkan Lingkungan Kerja (X2) tidak mempunyai pengaruh signifikan. Namun jika diteliti secara bersama-sama, Fasilitas (X1) dan Lingkungan Kerja (X2) berpengaruh signifikan dan positif terhadap Kinerja Pegawai (Y). Koefisien determinasi sebesar 0,312 menunjukkan bahwa kedua variabel tersebut secara bersama-sama memberikan kontribusi sebesar 31,2% terhadap variasi kinerja karyawan, dan sisanya sebesar 68,8% dipengaruhi oleh faktor lain yang tidak tercakup dalam penelitian ini.

This research was conducted at PT. Rajawali Berdikari Indonesia based in Depok, West Java, which specializes in Business Process Outsourcing (BPO) for contact centers. The aim of the research is to analyze the influence of facilities and work environment on the performance of contact center employees at PT. Rajawali Berdikari Indonesia, both individually and collectively. The research population was 57 employees, and the sample size was 50 people who were selected using the Slovin formula with probability sampling techniques. Data analysis was carried out using quantitative statistical methods and processed with IBM SPSS Statistics V.27 software. Research findings show that Facilities (X1) have a positive and significant influence on employee performance (Y) when viewed independently, while the Work Environment (X2) does not have a significant influence. However, if examined together, Facilities (X1) and Work Environment (X2) have a significant and positive effect on Employee Performance (Y). The coefficient of determination of 0.312 indicates that these two variables together contribute 31.2% to the variation in employee performance, and the remaining 68.8% is influenced by other factors not covered in this research..
Le crépuscule des idoles
Authors: O’Toole Darren 
Published: September 2024

Depuis que la Cour suprême du Canada a rendu sa décision dans R. c.
Powley en 2003, les revendications d’identité métisse ont considérablement
augmenté à chaque recensement. Plus récemment, a émergé un sous-domaine des études
métisses qui prône l’existence de communautés métisses dans les provinces de l’Est
du Canada (Ontario, Québec, Nouveau-Brunswick et Nouvelle-Écosse). Certains
chercheurs actifs dans ce sous-domaine instrumentalisent quelques extraits
sélectionnés dans les oeuvres de Louis Riel pour discréditer le nationalisme métis
« de l’Ouest » contemporain comme étant « exclusif » et pour étayer les
revendications des « Métis de l’Est » comme étant « inclusives ». Cet article se
penche sur plusieurs de ces extraits en les plaçant d’abord dans leur contexte
textuel immédiat et en considérant leur logique interne. Nous les plaçons ensuite
dans l’économie générale des projets politiques de Riel. Un examen approfondi révèle
un nationalisme beaucoup plus étroit que le nationalisme métis contemporain, que ce
soit en termes ethniques, linguistiques, religieux ou géographiques.
Trends and sensitivities of low streamflow extremes to discharge timing and magnitude in Pacific Northwest mountain streams
Authors: Kormos Patrick R. , Luce Charles H. , Wenger Seth J. , Berghuijs Wouter R. 
Published: May 2016

AbstractPath analyses of historical streamflow data from the Pacific Northwest indicate that the precipitation amount has been the dominant control on the magnitude of low streamflow extremes compared to the air temperature‐affected timing of snowmelt runoff. The relative sensitivities of low streamflow to precipitation and temperature changes have important implications for adaptation planning because global circulation models produce relatively robust estimates of air temperature changes but have large uncertainties in projected precipitation amounts in the Pacific Northwest U.S. Quantile regression analyses indicate that low streamflow extremes from the majority of catchments in this study have declined from 1948 to 2013, which may significantly affect terrestrial and aquatic ecosystems, and water resource management. Trends in the 25th percentile of mean annual streamflow have declined and the center of timing has occurred earlier. We quantify the relative influences of total precipitation and air temperature on the annual low streamflow extremes from 42 stream gauges using mean annual streamflow as a proxy for precipitation amount effects and streamflow center of timing as a proxy for temperature effects on low flow metrics, including 7q10 summer (the minimum 7 day flow during summer with a 10 year return period), mean August, mean September, mean summer, 7q10 winter, and mean winter flow metrics. These methods have the benefit of using only readily available streamflow data, which makes our results robust against systematic errors in high elevation distributed precipitation data. Winter low flow metrics are weakly tied to both mean annual streamflow and center of timing.
Magnetospheric Multiscale Mission observations and non‐force free modeling of a flux transfer event immersed in a super‐Alfvénic flow
Authors: Farrugia C. J. , Lavraud B. , Torbert R. B. , Argall M. , Kacem I. , Yu W. , Alm L. , Burch J. , Russell C. T. , Shuster J. , Dorelli J. , Eastwood J. P. , Ergun R. E. , Fuselier S. , Gershman D. , Giles B. L. , Khotyaintsev Y. V. , Lindqvist P. A. , Matsui H. , Marklund G. T. , Phan T. D. , Paulson K. , Pollock C. , Strangeway R. J. 
Published: May 2016

AbstractWe analyze plasma, magnetic field, and electric field data for a flux transfer event (FTE) to highlight improvements in our understanding of these transient reconnection signatures resulting from high‐resolution data. The ∼20 s long, reverse FTE, which occurred south of the geomagnetic equator near dusk, was immersed in super‐Alfvénic flow. The field line twist is illustrated by the behavior of flows parallel/perpendicular to the magnetic field. Four‐spacecraft timing and energetic particle pitch angle anisotropies indicate a flux rope (FR) connected to the Northern Hemisphere and moving southeast. The flow forces evidently overcame the magnetic tension. The high‐speed flows inside the FR were different from those outside. The external flows were perpendicular to the field as expected for draping of the external field around the FR. Modeling the FR analytically, we adopt a non‐force free approach since the current perpendicular to the field is nonzero. It reproduces many features of the observations.
Longitudinal improvement and stability of olfactory function in the evaluation of surgical management for chronic rhinosinusitis
Authors: Levy Joshua M. , Mace Jess C. , Sansoni E. Ritter , Soler Zachary M. , Smith Timothy L. 
Published: May 2016

BackgroundAbnormal olfaction is common with chronic rhinosinusitis (CRS) and associates with various measures of sinonasal inflammation. The Brief Smell Identification Test (BSIT) has demonstrated improvements in abnormal olfactory detection following endoscopic sinus surgery (ESS), but olfaction remains understudied using this instrument. Discerning longitudinal, postoperative durability in olfaction is critical for patient counseling.MethodsAdult participants with medically recalcitrant CRS were prospectively enrolled into a multi‐institutional cohort study and observed for 18 months after ESS. Olfaction was operationalized using BSIT scores collected at baseline, 6 months, 12 months, and 18 months postoperatively and compared using repeated measures analysis of variance (ANOVA).ResultsA total of 122 participants met inclusion criteria and were recruited between March 2011 and February 2014. Improvement in mean BSIT scores at 6‐month follow‐up were reported for all participants (p = 0.014) with greatest improvement in subjects with nasal polyposis (p = 0.001). No differences in mean BSIT scores were found between 6 months and 18 months overall; however, subjects with comorbid asthma (F(2) = 5.29; p = 0.010) and nasal polyposis (F(2) = 3.99; p = 0.033) reported significant mean worsening. Prevalence of abnormal olfaction decreased from 28% preoperatively to 17% at 6 months (p = 0.015), for all subjects, without significant change at 12 months (19%; p = 0.791) or at 18 months (21%; p = 0.581) postoperatively.ConclusionPostoperative improvement in olfaction was reported 6 months after ESS using BSIT scores, with greatest improvements in patients undergoing polypectomy. Overall improvement persisted between 6 months and 18 months after ESS for most patient subgroups; however, dysosmia worsened after initial improvement in patients with asthma and nasal polyps, highlighting the need for further identification of prognostic factors associated with abnormal olfaction in CRS.
Myeloid‐Derived Suppressor Cells Induce the Expansion of Regulatory B Cells and Ameliorate Autoimmunity in the Sanroque Mouse Model of Systemic Lupus Erythematosus
Authors: Park Min‐Jung , Lee Sung‐Hee , Kim Eun‐Kyung , Lee Eun‐Jung , Park Sung‐Hwan , Kwok Seung‐Ki , Cho Mi‐La 
Published: May 2016

ObjectiveThis study was undertaken to assess the effect of myeloid‐derived suppressor cells (MDSCs) on various B cell subsets, including regulatory B cells, as well as to assess the potential therapeutic effects of MDSC infusion in an animal model of systemic lupus erythematosus (SLE).MethodsSplenocytes were cultured with MDSCs, and the populations of various B cells and effector T cell subsets were analyzed by flow cytometry. Lupus mice (roquinsan/san mice) were treated intravenously with MDSCs obtained from C57BL/6 mice, and the levels of serum autoantibodies, degree of proteinuria, histologic changes in the kidney, and populations of various B cell and T cell subsets in the spleen were analyzed.ResultsCoculture of MDSCs with splenocytes from C57BL/6 mice resulted in an expansion of the population of interleukin‐10–producing B cells. The expansion of regulatory B cells was completely blocked by the addition of NG‐monomethyl‐l‐arginine, an inhibitor of inducible nitric oxide synthase (iNOS). Infusion of MDSCs resulted in a reduction of serum anti–double‐stranded DNA antibody levels and degree of proteinuria and an improvement in renal pathology in the roquinsan/san mice. MDSC coculture also resulted in a decrease in the population of effector B cells, such as germinal center B cells and plasma cells. Moreover, infusion of MDSCs resulted in an expansion of the regulatory B cell population as well as a decrease in follicular helper T cells, Th1 cells, and Th17 cells in the spleens of roquinsan/san mice.ConclusionOur results indicate the MDSCs induce expansion of regulatory B cells via iNOS and ameliorate autoimmunity in a murine model of SLE. These findings indicate that MDSCs may be a promising therapeutic strategy for targeting B cell–mediated autoimmune diseases.
Ein pharmakologischer Prozeß und seine stochastische Beschreibung
Authors: Herrmann H. 
Published: May 2016

AbstractDie vorliegende Erörterung, sie greift zurück auf die Dissertation des Verfassers, widmet sich der quantitativen Beschreibung des sog. Reiz‐Antwort‐Prozesees der Pharmakon‐Rezeptor‐Theorie mit Hilfe von stochastischen Modellen. Zunächst wird der pharmakologische Prozeß erfaßt durch Hypothesen über Eigenschaften und Verhalten von Pharmakon‐Molekülen und Rezeptoren und über die Art und Entstehung von Antworten. In das zu konstruierende stochastische Modell für den pharmakologiechen Vorgang geht ein zweidimensionaler homogener Geburts‐ und Todesprozeß mit nichtlinearen Übergangsintensitäten ein. Die Existenz und Eindeutigkeit von Lösungen des zugehörigen Kolmogorov'schen Vorwärtsdifferentialgleichungssystems wird nachgewiesen. Ferner wird gezeigt, daß der stochastische Prozeß ergodisch ist und so die Beschreibung des pharmakologischen Gleichgewichtszustandes erlaubt. Bei nur geringfügig geändertem Modellansatz ist es trotz nichtlinearer Übergangsintensitäten möglich, die besonders interessierenden Erwartungswert‐ und Kovarianzfunktionen als Lösungen gewisser Differentialgleichungen explizit anzugeben. Dazu ein analytischer Vergleich mit den entsprechenden Funktionen eines analogen deterministischen Modells einschließlich graphischer Darstellung.
MiRNA expression profile of ionizing radiation‐induced liver injury in mouse using deep sequencing
Authors: Lu Jike , Chen Chen , Hao Limin , Zheng Zhiqiang , Zhang Naixun , Wang Zhenyu 
Published: May 2016

AbstractIn order to investigate the potential regulatory roles of microRNAs (miRNAs) in mouse response to ionizing radiation (IR), the small RNA libraries from liver tissues of mice with or without ionizing radiation (IR) were sequenced by high‐throughput deep sequencing technology. A total of 270 miRNAs including 212 known and 58 potentially novel miRNAs were identified. Within these miRNAs, there were 48 miRNAs that were differentially expressed, including 27 known and 21 novel miRNAs. The results of quantitative RT‐polymerase chain reaction (qRT‐PCR) were in consistent with the sequencing analysis. Target gene prediction, function annotation, and pathway of the identified miRNAs were analyzed using RNAhybrid, miRanda software and Swiss‐Prot, Gene Ontology (GO), Clusters of Orthologous Groups (COG), Kyoto Encyclopedia of Genes, and Genomes (KEGG) and non‐redundant (NR) databases. These results should be useful to investigate the biological function of miRNAs under IR‐induced liver injury.
Optimal Design of a Gas‐to‐Liquids Process with a Staged Fischer‐Tropsch Reactor
Authors: Rafiee Ahmad , Panahi Mehdi 
Published: May 2016

AbstractThe optimal design of a natural gas‐to‐liquid hydrocarbons (GTL) process with a multistage cobalt‐based Fischer‐Tropsch reactor and interstage product separation is considered. The objective function is to maximize the wax (C21+) production rate at the end of the reactor path. Sectioning of the Fischer‐Tropsch reactor increases the chain growth probability inside the reactor which results in a higher production of wax. The carbon efficiency of the two‐stage reactor is distinctly higher than that of the single‐stage reactor.