bluuebunny/crossref_metadata_2025_split huggingface dataset:
The breakthrough of oxide pathway mechanism in stability and scaling relationship for water oxidation
Authors: Yin Zhao-Hua , Liu Hong , Hu Jin-Song , Wang Jian-Jun 
Published: October 2024

ABSTRACT
An in-depth understanding of electrocatalytic mechanisms is essential for advancing electrocatalysts for the oxygen evolution reaction (OER). The emerging oxide pathway mechanism (OPM) streamlines direct O–O radical coupling, circumventing the formation of oxygen vacancy defects featured in the lattice oxygen mechanism (LOM) and bypassing additional reaction intermediates (*OOH) inherent to the adsorbate evolution mechanism (AEM). With only *O and *OH as intermediates, OPM-driven electrocatalysts stand out for their ability to disrupt traditional scaling relationships while ensuring stability. This review compiles the latest significant advances in OPM-based electrocatalysis, detailing design principles, synthetic methods, and sophisticated techniques to identify active sites and pathways. We conclude with prospective challenges and opportunities for OPM-driven electrocatalysts, aiming to advance the field into a new era by overcoming traditional constraints.
Rethinking economic socialization: the intersection of culture, gender and economic life in a religious enclave
Authors: Hayes Adam S , Miletzky Yehudit 
Published: October 2024

AbstractThis article explores how economic socialization serves as a bridge between individual economic behaviors and the broader social and cultural contexts that shape them. Drawing on a post-functionalist approach to socialization, the study examines the ultra-Orthodox Jewish (Haredi) community in Israel, where distinct gender roles, cultural norms and patterns of economic participation create a unique context for investigating divergent economic socialization pathways. Comparing four groups within the Haredi community—average/below-average and high-income women, men with work experience, and men who study at religious seminaries (Yeshiva/Kollel)—analysis of an original survey study reveals how differential exposure to economic life leads to significant variations in financial risk-taking, loss-aversion, financial literacy and competitiveness. The findings problematize explanations attributing economic gender gaps to innate differences, instead highlighting the profound impact of the cultural framing of gender roles vis-à-vis economic integration. By foregrounding economic socialization as a sociological phenomenon, the study contributes to discourses on culture’s role in economic behavior and opens new avenues for examining how individuals acquire economic dispositions through socialization pathways shaped by structural constraints and power relations.
Novel gene therapies for sickle cell disease, Duchenne muscular dystrophy, and hemophilia A
Authors: Solano Laura 
Published: October 2024

ABSTRACT
This article discusses novel genetic therapies for sickle cell disease, Duchenne muscular dystrophy, and hemophilia A. Gene therapies have the potential to deliver more targeted and effective approaches to treatment, especially for rare diseases for which the availability of approved therapies is limited. This article describes the first FDA-approved CRISPR/Cas9 treatment and the treatment protocols, indications, warnings, precautions, cost, and contraindications of four novel genetic therapies.
T-cell Clonality in Pleomorphic Dermal Sarcoma in Male Veterans: A Report of 2 Cases and a Review of the Literature
Authors: Oh Kei Shing , Mahalingam Meera 
Published: October 2024

Abstract:
The standard treatment of choice for pleomorphic dermal sarcoma (PDS), a relatively uncommon soft tissue sarcoma and 1 morphologically similar to atypical fibroxanthoma, is wide local excision with close clinical follow-up. Studies regarding management of advanced/metastatic PDS with immune checkpoint inhibitors are limited as most STSs have historically been viewed as being immunologically inert. Contradicting this belief, in this report, we describe 2 cases of PDS with a robust host response. Histopathology of both cases revealed a dermal neoplasm comprising mitotically active, pleomorphic, spindled-to-ovoid cells, which were immunohistochemically negative for keratinocytic, melanocytic, and smooth muscle markers. An unusual feature in both cases was the presence of a brisk host response. Additional workup of the infiltrating lymphocyte population revealed an abnormal CD4:CD8 ratio in both cases, with the proportion of CD8+ lymphocytes surpassing (case 1) and equaling (case 2) that of the CD4+ T-lymphocyte population. The increased proportion of CD8+ lymphocytes prompted the additional workup of TCR gene rearrangement, which revealed a clonal population of T lymphocytes in both cases. The robust and clonal T-lymphocyte host response in both of our cases suggests that PDS appears to fit the classic model of an inflammatory-type tumor and may be a candidate for checkpoint inhibition. Future work includes additional reports of cases of PDS with an infiltrating clonal T-lymphocyte population and detailing the function and specificity of the infiltrating T lymphocytes to ascertain whether they have the potential to recognize and lyse the tumors they colonize.
Vulvar Skin Metastasis From Cervical Adenocarcinoma
Authors: Deng Zhongyun , Li Wenjie , Tang Xiaomin , Zhao Bei , Li Juan , Rang Zhen , Yang Ge , Liu Wei , Cui Fan 
Published: October 2024

Abstract:
Cervical cancer stands as one of the most common gynecologic malignancies in developing countries; however, cutaneous metastasis from cervical cancer is a rare occurrence. In this study, we present a case involving a 44-year-old woman diagnosed with International Federation of Gynecology and Obstetrics stage IIA gastric-type endocervical adenocarcinoma. Two years later, after undergoing radical hysterectomy and chemoradiation therapy, she exhibited cutaneous metastasis in the vulvar region.
LMNA::NTRK1 and PRDX1::NTRK1 Atypical Spitz Tumor: A Report of Two Additional Cases With Histological, Immunohistochemical, and Molecular Insights
Authors: Cazzato Gerardo , Colagrande Anna , Resta Leonardo , Trilli Irma , Lupo Carmelo , Ingravallo Giuseppe , Caporusso Concetta , Giovannoni Isabella , Barresi Sabina 
Published: October 2024

Abstract:
Over the past decade, advancements in molecular biology have contributed to changes in the diagnostic classification of Spitz neoplasms, including Spitz nevi, atypical Spitz tumors, and Spitz melanomas. The recent World Health Organization classification of skin tumors identifies fusion kinases, including NTRK1, NTRK2, and NTRK3, as critical drivers of these lesions. New fusion genes have continued to expand the spectrum of known molecular alterations, particularly within the category of Spitz NTRK-rearranged lesions. We present 2 new cases of NTRK-rearranged Spitz lesions: an atypical Spitz tumor with common LMNA::NTRK1 fusion and an atypical Spitz tumor with a rare PRDX1::NTRK1 fusion. Clinical, histopathological, immunohistochemical, and molecular analyses were performed to diagnose these patients. This report adds to the growing body of knowledge on NTRK-rearranged Spitz lesions and underscores the importance of integrating molecular findings with morphological and immunohistochemical data for the accurate classification and understanding of these neoplasms.
Comparison of intraocular lens power formulas for negative diopter intraocular lens implantation for high myopia
Authors: Whang Woong-Joo , Koh Kyungmin , Hoffer Kenneth J. , Schiano-Lomoriello Domenico , Lupardi Enrico , Taroni Leonardo , Tchah Hungwon , Savini Giacomo 
Published: October 2024

Purpose:
To compare the accuracy of intraocular lens (IOL) power calculation formulas for myopic eyes requiring negative diopter-powered IOLs.

Design:
Retrospective case series.

Setting:
Kim's Eye Hospital, College of Medicine, Konyang University, Seoul, South Korea and Yeouido St. Mary Hospital, Seoul, South Korea.

Methods:
61 eyes that underwent phacoemulsification with implantation of a negative power IOL were investigated. The trueness, precision, and accuracy of IOL power calculation were assessed for the Barrett Universal II (BUII), EVO 2.0, Haigis, Hoffer QST, Holladay 1, and SRK/T formulas using the Eyetemis online tool. The analysis was performed using (1) the ULIB IOL constants and (2) after constant optimization.

Results:
With ULIB constants, the Haigis, Holladay 1, and SRK/T resulted in a hyperopic mean prediction error (PE) >1.00 diopter (D), which was significantly different from zero (adjusted P < .05). The mean PE of the remaining formulas was closer to zero. The absolute PE was significantly higher with the Holladay 1 and SRK/T (adjusted P < .05) with respect to the remaining formulas. After constant optimization, the outcomes of traditional formulas improved and no statistically significant differences were found among any of the formulas in trueness, precision, and accuracy. The percentage of eyes with an absolute PE within 0.50 D was low (<50%) even after constant optimization.

Conclusions:
With ULIB constants, the BUII, EVO 2.0, and Hoffer QST were more accurate than traditional formulas in eyes with negative diopter IOLs. The results of IOL power calculation in these eyes remain poor even after constant optimization.
Whole blood viscosity and its association with the presence and severity of hearing loss and other microangiopathies in Indian patients with type 2 diabetes mellitus
Authors: Mendonca Jane , Boloor Archith , Manoj Matthew A. , Singh Tanya , Correa Tulio L. 
Published: October 2024

Abstract

Background/Aims:
Although studies correlating idiopathic sensorineural hearing loss (SNHL) to whole blood viscosity (WBV) have been conducted, no such study has been done in diabetic patients in whom WBV is said to be altered. Therefore, we aimed to investigate the potential association between calculated WBV and the presence and severity of SNHL and other microangiopathies in Indian patients with type 2 diabetes mellitus (T2DM).

Methods:
A cross-sectional study was carried out in the Kasturba Medical College (KMC) group of hospitals among individuals who were older than 18 years and had T2DM. The included patients underwent pure-tone audiometry, ophthalmoscopy, monofilament test, and routine blood investigations for diabetes. WBV was derived using hematocrit and total protein with a validated formula.

Results:
Of the total 60 participants, 73.3% had SNHL, which was predominantly bilateral and moderate. There was a statistically significant association between glycemic control and the degree of SNHL. The associations between SNHL and HbA1C levels and random plasma glucose were both statistically significant (P = .001). The statistical association between WBV and the degree of SNHL was not significant (P = .056). Although higher mean blood viscosity was noted in individuals with diabetic retinopathy and neuropathy than those without, the associations between blood viscosity and the presence of retinopathy, neuropathy, and nephropathy were not statistically significant (P = .238, P = .621, and P = .656; respectively). Finally, the associations between WBV and glycemic control were also not significant (P = .652 for random plasma glucose and P = .928 for HbA1C).

Conclusion:
This study concludes that SNHL is highly prevalent in diabetes, and poor glycemic control is associated with its worsening. Elevations in WBV, if present, are not affected by poor glycemic control and do not appear to significantly contribute to the development of complications of the microvasculature in T2DM.
A New Model to Advance a Collaborative Clinical Education Placement Process: A Consortium Core Network
Authors: Bayliss Jamie , Berg-Carramusa Cara A. , Both Amy , Knettle Mari , Reynolds Emily 
Published: October 2024

Background and Purpose.
The 2014 Clinical Education (CE) Summit and subsequent scholarly work prompted development of collaborative, mutually beneficial, innovative processes to mitigate CE challenges and inefficiencies. Contemporary practice advocates for collaboration among physical therapist (PT) academic programs (Programs) and clinical partners (Partners) to create a sustainable placement process with mutual benefits for stakeholders. The purpose of this article is to describe the design and implementation of the Ohio Kentucky Consortium of Physical Therapy Educators (Consortium) Consortium Core Network's (CCN) centralized PT CE Placement Process (PT-CEPP) model and share participants' experience perspectives.

Methods/Model Description and Evaluation.
The Consortium established the CCN and a Steering Committee, representing stakeholders, and designed a novel 5-phase centralized PT-CEPP model, in Exxat, an educational management platform. The phases included Request, Offer, Placement, Reallocation, and Confirmation and Release. A postimplementation Qualtrics survey was disseminated to obtain participant perspectives. Open-text survey responses were compiled, reviewed, thematically analyzed, and presented in this article (part 1). The resulting quantitative CCN PT-CEPP analyses were deferred to a companion article (part 2).

Outcomes.
The CCN participation included invited Partners (n = 101/364; 28%) and Programs (n = 14/14; 100%). During initial PT-CEPP implementation, 1,005 offers resulted in 549 CE placements. Participant perspectives from 20 of 101 SCCEs (20%) and eight of 14 DCEs (57%) were dichotomized into “Benefits and What Worked Well” and “Challenges and What Did Not Work Well.” Perspectives were unique to participant roles, with partners valuing “centralization” and Programs “process.”

Discussion and Conclusions.
Lessons gleaned from the PT-CEPP paradigm shift to a CCN-centralized model may optimize processes and improve sustainability with future iterations.
Icodec ONWARDS: A review of the first once-weekly diabetes treatment for nurse practitioners and physician assistants
Authors: Kruger Davida , Magwire Melissa , Urquhart Scott 
Published: October 2024

Background:
Diabetes management is challenged by the complexity of treatment regimens and the need for frequent injections, affecting patient adherence and quality of life. Insulin icodec, a once-weekly basal insulin analog, represents a significant innovation, potentially simplifying diabetes care and improving outcomes.

Objectives:
This review aims to evaluate the safety, efficacy, and clinical implications of insulin icodec for individuals with type 1 and type 2 diabetes, highlighting its potential to affect current treatment paradigms.

Data Sources:
A review was conducted comparing once-weekly insulin icodec with daily basal insulin analogs using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to ensure transparent reporting of systematic reviews. A search was performed in the following databases: PubMed, Google Scholar, Embase, and ClinicalTrials.gov, focusing on efficacy and safety outcomes.

Conclusions:
Insulin icodec has demonstrated effective glycemic management and a safety profile comparable to daily basal insulins. Its extended half-life and steady-state glucose-lowering effect have the potential to reduce the burden of daily injections and improve patient adherence.

Implications for Practice:
The introduction of once-weekly insulin icodec represents an advancement in diabetes care. For front-line clinicians, this innovation aligns with the need for more straightforward medication regimens. Coupled with continuous glucose monitoring systems, it enables a more personalized and efficient approach to diabetes management, with the potential to improve patient satisfaction and clinical outcomes. This underscores the impact of integrating such advancements into practice, highlighting the role of nurse practitioners and physician assistants in adopting these innovations to optimize patient care.
Bedside to bench and back again-translational research in interventional pulmonology
Authors: Iqbal Beenish , Choi Hee Jae , Kanellakis Nikolaos I. , Akulian Jason , Rahman Najib M. 
Published: October 2024

Purpose of review
Translational research in Interventional Pulmonology has made significant advances in recent years, ranging from novel biomarkers and imaging to practice-changing clinical trials in lung cancer and pleural disease. This review article aims to summarize key research studies in the field to understand the latest published evidence and to highlight areas of growing academic interest.

Recent findings
In lung cancer, the role of novel imaging and biomarkers and their potential utility in early lung cancer diagnosis will be highlighted. In pleural disease, less invasive/conservative treatment in pneumothorax, early aggressive treatment in pleural infection along with novel biomarkers, and the shift beyond drainage strategies in malignant pleural effusion and mesothelioma will be discussed.

Summary
This overview of translational research in the field of interventional pulmonology will ultimately help to highlight the gaps in current evidence to promote research in areas of clinical significance.
Efficacy and Safety of Ibrutinib as Monotherapy or Combination Therapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL): A Systematic Review and Meta-analysis
Authors: Li Yin , Li Chunfan , Lv Kebing , Wang Shixuan , Li Fei 
Published: October 2024

Background:
Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous disease group. Ibrutinib's monotherapy or combination therapy is effective in relapsed/refractory (R/R) DLBCL. However, the treatment response in R/R DLBCL varies from 15% to 90% with different regimens, and the tolerance remains controversial.

Areas of Uncertainty:
The efficacy and safety of ibrutinib monotherapy or combination therapy in patients with R/R DLBCL remain uncertain.

Data Sources:
The PubMed, CBM, MEDLINE, Cochrane Library, and Embase databases were searched from their inception to July 2021.

Therapeutic Advances:
The total complete remission rate (CRR) and overall response rate in R/R DLBCL patients treated with ibrutinib were 26% and 49%, respectively. The CRR of ibrutinib combination therapy was significantly higher than the ibrutinib monotherapy (45% vs. 19%). Moreover, the CRR of patients was 40% in double expressing lymphoma, 35% in central nervous system lymphoma, and 33% in nongerminal center B-cell–like (non-GCB) DLBCL, which was higher than the 8% in those with the GCB subtype. The pooled median PFS and overall survival were 5.57 and 10.17 months, respectively. GCB-DLBCL had the worst overall survival (5.1 months). Nevertheless, we found that combination regimens had no survival advantage compared with monotherapy (P > 0.05), indicating that combination therapy was only a transitional treatment and bridge for chimeric antigen receptor T cells or other treatments. Moreover, 12% of patients on ibrutinib combination therapy had ≥grade 3 adverse events compared with 9% on ibrutinib monotherapy.

Conclusions:
Ibrutinib monotherapy or combination therapy was safe and effective in treating R/R DLBCL with tolerable adverse reactions.
Application of 18F-fluorodeoxyglucose PET/computed tomography in the diagnosis of infiltrative subsolid nodules in lung adenocarcinoma
Authors: Jiang Chunting , Zhao Meixin , Zhang Weifang 
Published: October 2024

Purpose
To investigate the diagnostic value of 18F-fluorodeoxyglucose(FDG) PET/computed tomography (CT) for infiltrative subsolid nodules at different stages of lung adenocarcinoma and to explore predictive factors for invasive adenocarcinoma, providing compelling evidence for timely intervention.

Methods
A retrospective analysis was conducted on PET/CT imaging data of 170 subsolid nodules lesions confirmed postoperatively as lung adenocarcinoma or precursor glandular lesions. Lesions were categorized into preinvasive lesions including atypical adenomatous hyperplasia and adenocarcinoma in situ, microinvasive adenocarcinoma, and invasive adenocarcinoma. Compared the differences in imaging features and metabolic parameters among different groups and used a multifactor logistic regression model and receiver operating characteristic curve analysis to identify predictive factors for invasive adenocarcinoma.

Results
From preinvasive lesions through microinvasive adenocarcinoma to invasive adenocarcinoma, there was a gradual increase in nodule diameter, nodule area, and proportion of part-solid nodule. Statistical significance (P < 0.05) was observed in the rates of spiculation and pleural indentation between preinvasive lesions versus microinvasive adenocarcinoma and invasive adenocarcinoma groups. The maximum standardized uptake value and maximum standardized uptake ratio show statistically significant differences (P < 0.05) between the invasive adenocarcinoma group and the other groups. Logistic regression analysis indicated that nodule composition, nodule diameter, and maximum standardized uptake ratio were predictive factors for invasive adenocarcinoma (P < 0.05). For part-solid nodules, the longest diameter of the solid component has a high diagnostic value.

Conclusion
The imaging features of 18F-FDG PET/CT contribute to the diagnosis of infiltrative subsolid nodules at different stages of lung adenocarcinoma, providing robust evidence for timely intervention.
Diagnostic value of baseline 18F-FDG PET/CT and peripheral blood inflammatory markers for aggressive lymphoma in non-Hodgkin’s lymphoma
Authors: Jia Qichen , Wang Aihui , Liu Yuang , Fan Yishuo , Zhou Xiaohong , Liu Yupeng , WU Liying , Ouyang Xiaohui , Su Jiagui , Shi Baolong , Liu Xiaofei 
Published: October 2024

Purpose
This study aims to investigate the diagnostic value of baseline F18 fluorodeoxyglucose (FDG) PET/computed tomography (CT) parameters and peripheral blood inflammatory markers in aggressive lymphoma of non-Hodgkin lymphoma (NHL) and the correlation between peripheral blood inflammatory markers and maximum standardized uptake value (SUVmax).

Patients and methods
We conducted a retrospective analysis including 121 patients with NHL. Patients were divided into aggressive lymphoma group and indolent lymphoma group. Mann–Whitney U test, chi-square test and multivariate stepwise logistic regression were used to analyse. Subsequently, receiver operating characteristic (ROC) curve analysis was conducted to evaluate the diagnostic performance. Additionally, Spearman correlation analysis was utilized to explore the correlation between peripheral blood inflammatory markers and SUVmax.

Results
Leptin mass criterion uptake value (SUL)max, SUVmax, SUVavg, SUVpeak, focal SUVmax/liver SUVmax, focal SUVmax/ mediastinal SUVmax, SULavg, SULpeak, systemic immune-inflammation, neutrophil ratio, total lesion glycolysis, neutrophils versus lymphocyte ratio, platelet-to-lymphocyte ratio, hemoglobin-to-white blood cell ratio, lactate dehydrogenase and lymphocyte ratio between two groups were statistically significant (P < 0.05). SUVmax was an independent influencing factor, and the area under the ROC curve was 0.862. There was a positive correlation between the platelet-to-lymphocyte ratio and SUVmax (r = 0.239; P = 0.008).

Conclusion
PET/CT parameters and peripheral blood inflammatory markers have certain value in the diagnosis of aggressive lymphoma in NHL, among which SUVmax is an independent influencing marker and is positively correlated with PLR.