bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors for Early Implant-Related Surgical Site Infection
Authors: Kok Ta Wei Kevin , Agrawal Nikunj , Sathappan SS , Chen Weijing Kelven 
Published: October 2016

Purpose. To identify the risk factors and microbes associated with early implant-related surgical site infection (SSI). Methods. Records of 193 implant-related SSIs secondary to primary orthopaedic surgery were reviewed. Early and late SSI was defined as infection diagnosed within and after 3 months of surgery, respectively. Results. Of the 193 implant-related SSIs, 29 were superficial incisional, 127 were deep incisional, and 37 were organ/space-related. 144 (90%) out of 160 SSIs used cefazolin in their prophylactic antibiotic regimen. In univariate analysis, early SSI was associated with diabetes mellitus, American Society of Anesthesiologists (ASA) score of >2, emergency procedures, and lack of antibiotic prophylaxis. In multivariable analysis, early SSI was associated with an ASA score of >2 (p=0.016). Conclusion. It is important to cross-check ASA score with co-morbidities to reduce early SSIs. Perioperative optimisation and antibiotic prophylaxis should be administered prior to surgery. Appropriate modification of antibiotic prophylaxis should be considered.
Wrist Fusion through Centralisation of the Ulna for Recurrent Giant Cell Tumour of the Distal Radius
Authors: Meena Dinesh Kumar , Thalanki Srikiran , Sharma Shiv Bhagwan 
Published: October 2016

Purpose. To review the outcome of wide resection and wrist fusion through centralisation of the ulna for recurrent giant cell tumour (GCT) of the distal radius in 10 patients. Methods. Records of 7 women and 3 men aged 25 to 40 years who underwent wide resection and wrist fusion through centralisation of the ulna for grade I (n=6) and grade II (n=4) recurrent GCT of the distal radius were reviewed. Functional outcome was evaluated using the modified Musculoskeletal Tumor Society scoring system. Grip strength and range of motion of the metacarpophalangeal joint were also assessed. Results. The mean follow-up period was 45 (range, 30–60) months. All tumours were benign and there was no evidence of metastasis. The mean grip strength was 45% (range, 30–70%) of the contralateral side. All patients achieved normal range of motion of the metacarpophalangeal and interphalangeal joints, but 4 patients had an extensor lag of the thumb. The mean time to wrist fusion was 6 (range, 4–8) months: 3 to 4 months for the 6 patients with bone grafting and 5 to 6 months for the 4 patients without bone grafting who developed painful subluxation necessitating total wrist arthrodesis using a plate and morcellised bone grafts. Conclusion. Wrist fusion through centralisation of the ulna for recurrent GCT of the distal radius is a viable option, despite a loss of wrist motion.
Cage Subsidence after Anterior Cervical Discectomy and Fusion Using a Cage Alone or Combined with Anterior Plate Fixation
Authors: Pinder Elizabeth M , Sharp David J 
Published: October 2016

Purpose. To compare the extent of cage subsidence after anterior cervical discectomy and fusion (ACDF) using a cage alone or combined with anterior plate fixation, and to assess the effect of end plate removal on cage subsidence. Methods. Records of 23 men and 13 women aged 32 to 82 (mean, 54) years who underwent ACDF for 61 levels using the Solis cage alone (n=46) or combined with anterior plate fixation (n=15) were reviewed. The extent of cage subsidence was determined by comparing immediately postoperative (within one week) with final follow-up radiographs. Cage subsidence was defined as the sum subsidence of the superior and inferior part of the cage into the vertebral body. Mild and major cage subsidence was defined as ≤2 mm and >2 mm, respectively. Results. Patients who underwent ACDF using a cage alone or combined with anterior plate fixation were comparable in terms of age, gender, follow-up duration, and number of levels decompressed. Cage subsidence occurred in 33 (54%) of the 61 levels decompressed. In the cage alone group, the extent of cage subsidence was greater (1.68 vs. 0.57 mm, p=0.039) and the rate of major cage subsidence was higher (28% vs. 7%, p=0.08). The inferior part of the cage was more vulnerable to subsidence compared with the superior part (median subsidence: 3.0 vs. 1.4 mm, p<0.0001). Cage subsidence occurred more often when the end plate was removed rather than preserved (58% vs. 18%, p<0.002). Conclusion. The extent of cage subsidence was greater after ACDF with cage alone. Cage subsidence occurred more often when the end plate was removed. Additional anterior plate fixation is recommended when the end plate is removed.
Expression of Inflammation/Pain-Related Genes in the Dorsal Root Ganglion following Disc Puncture in Rats
Authors: Fujioka Yuki , Stahlberg Anders , Ochi Mitsuo , Olmarker Kjell 
Published: October 2016

Purpose. To determine the expression of inflammation- and pain-related genes at days 1 and 3 in the dorsal root ganglion (DRG) of rats with or without disc puncture, using real-time quantitative polymerase chain reaction (RT-qPCR) with the TaqMan low-density array (TLDA). Methods. 53 female Sprague-Dawley rats were used. The left facet joint between L4 and L5 was removed, and the DRG and intervertebral disc between the vertebrae were exposed. The L4–5 intervertebral disc was punctured using a 0.4-mm diameter injection needle (disc puncture group) or left unpunctured (sham group). After one or 3 days, the 53 DRGs were harvested, frozen, and assessed for expression of inflammation-related genes. Total RNA was isolated from the DRGs. Expression of 119 genes related to inflammation and pain in the DRG after disc puncture were analysed using RT-qPCR with the TLDA. Results. Of the 95 inflammation-related genes, 78 genes were reliably detected. Two genes were significantly up-regulated: cysteinyl leukotriene receptor 1 (CYSLTR1) at day 3 and interleukin 2 receptor gamma (IL2RG) at day 1, and one gene was significantly down-regulated: phospholipase C beta 3 (PLCB3) at day 1. Of the 24 pain-related genes, 18 genes were reliably detected. Two genes were significantly up-regulated: nitric oxide synthase 1 (NOS1) at days 1 and 3 and 5-HT2A receptor (HTR2A) at day 1. Conclusion. Disc puncture may elicit changes in the expression of a variety of genes. Gene expression profiling is a useful tool for detecting new potential pharmaceutical targets for spinal pain syndromes.
2016 Roger A. Mann Award - Comparison of All-Inside Arthroscopic and Open Techniques in Treatment for Chronic Lateral Ankle Instability
Authors: Lee Young Koo , Yeo Eui Dong , Lee Kyung Tae , Lee Sun Geon 
Published: October 2016

Category: Sports. Introduction/Purpose: The modified Broström operation (MBO) is frequently used to treat chronic lateral ankle instability. The open MBO is currently the gold standard procedure for treatment of chronic lateral ankle instability. The all-inside arthroscopic MBO has been developed for chronic lateral ankle instability. Clinical outcome of all-inside arthroscopic MBO was reported as good or excellent. Biomechanically, the stiffness, torque to failure, and degree to failure of all-inside arthroscopic MBO and open MBO have the same results. But there were no report about comparison of clinical outcome between all-inside arthroscopic MBO and open MBO for chronic lateral ankle instability. The purpose of this study is to compare the clinical outcomes of the all- inside arthroscopic MBO and open MBO for chronic lateral ankle instability. Methods: From September 2013 to August 2014, MBO was performed in 87 patients. Of these, 50 consecutive patients were included in terms of inclusion criteria. All patients had giving way, persistent pain and an inability to resume one’s preinjury activity level for more than 6 months. Patients were randomized into 2 groups: all-inside arthroscopic MBO and open MBO using permuted block randomization method. Evaluation was performed preoperatively, at 6 weeks and 6 months postoperatively, and at a final follow-up a minimum of 12 months postoperatively using the Karlsson score, the American Orthopedic Foot and Ankle Society (AOFAS) hindfoot ankle score, pain Visual Analogue Scale (VAS), anterior talar translation, and talar tilt angle. Results: After randomization, 25 ankles were allocated in the all-inside arthroscopic MBO group, and 25 ankles were placed in the open MBO group. Two ankles in the open MBO group were excluded from analysis due to loss of follow-up. Therefore the evaluation was performed for 25 ankles in the all-inside arthroscopic MBO group and 23 ankles in the open MBO group. There were no differences in age, sex, symptom duration, preoperative Karlsson, AOFAS, and VAS scores between the 2 groups (P >.05). At final follow-up, the Karlsson, AOFAS, and VAS scores were significantly improved in both groups (P < .001). There were no differences in the Karlsson, AOFAS, VAS scores, anterior talar translation and talar tilt angle between the 2 groups at final follow-up (P >.05). Conclusion: There was no difference in the clinical evaluation and radiologic evaluation between all-inside arthroscopic MBO group and open MBO group at a minimum 12 months follow-up. All-inside arthroscopic MBO should be carefully considered as a reasonable alternative method in patients who have chronic lateral ankle instability.
Wound Complications Following 760 Total Ankle Replacements
Authors: Gross Christopher E. , Hamid Kamran S. , Green Cynthia , Adams Samuel B. , DeOrio James K. , Easley Mark E. , Nunley James A. 
Published: October 2016

Category: Ankle Arthritis. Introduction/Purpose: Wound complications following total ankle replacement (TAR) potentially lead to devastating consequences. The aim of this study is to compare the surgical and demographic differences in those with and without wounds which require operative management. We hypothesize that increased tourniquet and surgical time negatively influences wound healing. Methods: We retrospectively identified a consecutive series of 760 primary TARs performed between January 1998 and December 2014 whose data was prospectively collected. We then identified patients who required a secondary surgery to treat wound complications (ie operative debridement, split-thickness skin grafting, soft tissue reconstruction). All patients had operative wound debridement. We then compared demographics, surgical characteristics, and functional scores to see if there were any differences between the two groups. Clinical outcomes including secondary procedures and implant failure rate were recorded. Results: Twenty-seven patients (3.6%) had a total of 50 procedures to treat wound issues. 18 patients had flaps and 13 had split- thickness skin grafts. The mean time to operatively treating the wound was 12.6 weeks after the index TAR. The follow-up time from wound procedure was 28 months. Compared to the control group, patients with major wounds had a significantly longer surgery (215.6 vs. 189.2 min, p=.028) and tourniquet time (150.9 vs. 140 min, p=.0037). The control patients were more likely to have post-traumatic arthritis, whereas those with wound complications were more likely to have osteoarthritis (p=.002). Post- operatively, only the FAOS pain score was worse in patients with wounds (p=.047). There were seven failures in the major wound complication cohort (25.9%), including 2 BKAs. Conclusion: Ankle wounds which require operative management have high failure rates and may result in devastating outcomes. Given our data, we recommend limiting tourniquet time.
Effect of First Metatarsophalangeal Joint Arthrodesis on PROMIS Functional Outcomes and Radiographic Alignment for Hallux Rigidus
Authors: Dekker Robert G. , Alshouli Mohammed , Alvarez Andrew P. , Kadakia Anish R. 
Published: October 2016

Category: Midfoot/Forefoot Introduction/Purpose: Improvement in first ray alignment after arthrodesis of the arthritic first metatarsophalangeal (MTP) joint has been shown, yet few studies have attempted to correlate radiographic alignment with functional outcomes. The purpose of this study was to determine if 1st MTP joint deformity due to hallux rigidus correlates with patient reported pain and function, and whether there is a correlation between outcomes and radiographic measurements made before and after surgery. We also sought to determine how 1st MTP joint arthrodesis affects patient reported pain and function in a series of patients with hallux rigidus using a validated outcome measure. Methods: We conducted a retrospective study on patients treated with 1st MTP joint arthrodesis for diagnosis of hallux rigidus from 2012 to 2014 using a single surgical technique. The hallux-valgus angle (HVA), intermetatarsal angle (1-2 IMA) and lateral talar first metatarsal angle (L1TMTA) were measured independently by the senior author and an Orthopaedic Surgery fellow on pre- and post-operative radiographs. Inter-observer and intra-observer coefficients of repeatability were calculated. Pre- and post- operative physical function and pain scores were generated using the Patient Reported Outcome Measurement Information System (PROMIS). Paired t-test was used to detect differences. Bivariate analysis was used to assess radiographic measurement and PROMIS score correlation. Results: 30 subjects met inclusion criteria for radiographic analysis. Mean pre- and post-operative IMA, HVA and LT1MTA are shown in Table I. 23 subjects had pre-operative PROMIS data. Mean pre-operative pain and function were 72.7 and 32.0. Only pre-operative HVA significantly correlated with pre-operative physical function scores, with Pearson correlation value of 0.507 (p = 0.014). 7 subjects had pre- and post-fusion PROMIS data with average follow up 173 days post-fusion (minimum 130, maximum 196). Mean change in pain and function were -9.14 (p = 0.094) and 6.57 (p = 0.31), respectively. Only change in patient reported pain significantly correlated with change in HVA, with a Pearson correlation value of -0.76 (p = 0.05). Interclass correlation coeffecients for interoperator reliability ranged from 0.835 to 0.998. Conclusion: 1st MTP joint arthrodesis significantly improved radiographic IMA, HVA and LT1MTA for patients with hallux rigidus. In a small series of patients, arthrodesis improved patient reported pain and function, but this was not significant. Only pre-operative HVA correlated with pre-operative physical function, while only change in HVA correlated with change in patient reported pain after arthrodesis. Special attention should be paid to the HVA for the patient undergoing 1st MTP arthrodesis for hallux rigidus.
Partial Calcanectomy for Heel Ulcers Revisited – a Possible Solution to a Difficult Problem
Authors: Gellman Yechiel N. , Leibner Efraim D. , Haze Amir , Khaimov Nissim , London Eli , Elishoov Ofer 
Published: October 2016

Category: Diabetes Introduction/Purpose: Diabetic heel ulcers are a major problem, often leading to amputations. Partial or total calcanectomy has been described as a possible salvage procedure, by allowing soft tissue coverage after debridement of necrotic and infected tissue, and possibly allowing walking. We report on our experience with this technique which is not commonly used Methods: Fourteen patients, who presented with diabetic heel ulcers between 2010-15, and who were BKA candidates, underwent debridement and partial calcanectomy. Average age was 67.8 ±12.7 years, M:F ratio was 6:1 Extent of procedures, need for additional procedures and complications were noted. Outcome assessment included wound closure and walking status. No patients were lost to follow up. Results: Nine patients underwent partial calcanectomy as the initial procedure while others underwent prior debridement. Calcanectomies were subtotal (1), wedge (5) or partial (8). Primary closure was mostly achieved (11), the remainder requiring local skin graft (2) or myocutaneous flap (1). Ten patients underwent re-vascularization prior to calcanectomy, either angiographic (8) or bypass (2). Most calcanectomies (9/14) healed successfully, while five subsequently required amputations. Most failures were noticed within 24 days, with similar prevalence in wedge and partial calcanectomies. One patient had wound complications requiring BKA. At one year, the nine patients had full wound closure and could bear weight. Five patients regained full ambulatory status wearing specially modified shoes with custom fillers. Conclusion: Partial calcanectomy is a little-known procedure, that is a viable alternative to BKA. We present our positive experience with this procedure, which in a majority of cases not only prevented BKA, but also allowed weight bearing. Poor vascular supply is not necessarily a contraindication, as re-vascularization prior to calcanectomy is a viable option.
Hyaluronic Acid Dressing in the Treatment of Diabetic Foot Ulcer
Authors: Hwang Yeokgu , Park Yoo Jung , Shim Dong-Woo , Lee Moses , Park Kwang Hwan , Suh Jae Wan , Han Seung Hwan , Choi Woo Jin , Lee Jin Woo 
Published: October 2016

Category: Diabetes Introduction/Purpose: Fast and complete healing of a diabetic foot ulcer (DFU) is challenging due to the hostile wound healing environment of the diabetic patients. As a part of a multimodal treatment approach, advanced dressing material using hyaluronic acid (HA) has been found to be effective. However, previous studies have used HA with additional biologics, which interferes in determining the true clinical effect of HA in DFU. The purpose of this study is to examine the effectiveness and safety of a new HA dressing material in the treatment of DFU. Methods: This study was a prospective, randomized, placebo-controlled, single-center study conducted between September 2012 and January 2014. The inclusion criteria were type 1 or 2 diabetes, a ulcer size ≥ 1.0 cm2 that did not exhibit signs of healing for 6 weeks, Wagner grade 1 or 2, and palpable pulses at the ankle. The assessments of DFU included size, microbial culture study, detailed description of the DFU, and clinical photos. Patients in the study group were treated with an HA dressing material (hyaluronic acid 80 ± 5% and poloxamer 10 ± 5%), while patients in the control group were treated with a conventional moisture- retentive dressing (petrolatum gauze). Weekly follow-up was conducted with the dressing change up to maximum 12 weeks. Complete ulcer healing rate was evaluated as a primary endpoint. Additionally, healing velocity and the mean duration for achieving a 50% ulcer size reduction was compared between the two groups as a secondary endpoint. Results: Twenty-five patients were included in the final analysis (study group: 13, control group: 12). There were no significant differences between two groups regarding demographic factors and baseline DFU characteristics. The study group presented a significantly higher complete healing rate as compared to that in the control group [84.6% (11/13), 41.6% (5/12), respectively, P = 0.041]. Faster ulcer healing velocity and shorter mean duration for achieving a 50% ulcer size reduction were observed in the study group (P = 0.022, P = 0.004, respectively). The Kaplan-Meier analysis for the median time for 50% ulcer healing rate also showed a significantly shorter duration in the study group (21 days vs 39 days, P = 0.012). There were no adverse events related to the dressing materials. Conclusion: This study supports that a HA dressing without additional substances may offer a safe and effective treatment for DFU.
Outcomes of Iliac Crest Bone Marrow Aspirate Injection for the Treatment of Recalcitrant Non- Insertional Achilles Tendinitis
Authors: Talusan Paul G. , Dein Eric J. , Tan Eric W. , Zahoor Talal A. , Friedman Guy , Schon Lew C. 
Published: October 2016

Category: Sports Introduction/Purpose: Non-insertional Achilles tendinitis is a common cause of posterior ankle and heel pain in active and sedentary patients. Though the majority of patients respond to first-line non-operative management including activity modification, immobilization, orthotics, and physical therapy with tendon stretching, there is no consensus for patients that fail these treatments. We evaluate the role of iliac crest bone marrow aspirate concentrate (BMAC) as a safe and effective treatment option for recalcitrant cases. Methods: A retrospective chart review was conducted of patients with greater than 12 months of non-insertional Achilles tendinitis symptoms despite appropriate conservative treatment. Each patient had BMA harvested from the iliac crest, concentrated by centrifugation, and then injected into the Achilles tendon. Symptoms were assessed using the Visual Analogue Scale (VAS) pain score, collected at the preoperative office visit and at 6 weeks, 12 weeks, and 24 weeks after the procedure. Co- morbidities, concurrent procedures, and complications were also recorded. Results: A total of 21 patients (22 feet) were treated with iliac crest BMA concentrate injections. Preoperatively, the average VAS pain score was 6.8 (SD 2.0). Postoperatively, the average VAS was 4.0 (SD 2.5) at 6 weeks, 2.7 (SD 2.1) at 12 weeks, and 2.2 (SD 2.1) at 24 weeks. At 24 weeks postoperatively, there was a statistically significant decrease VAS score from baseline (p < 0.001), with a mean decrease by 4.6 (SD 3.1). There were no adverse effects reported at the surgical site or donor site morbidity at the iliac crest such as wound infection, hematoma, or persistent pain. Conclusion: Iliac crest BMAC appears to be a safe, effective, and potentially lasting treatment option for patients with intractable, non-insertional Achilles tendinitis. Patients demonstrated a statistically significant decrease in VAS pain score postoperatively with no complications at the donor or injection site.