bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary patterns are associated with the prevalence of alexithymia
Authors: Honkalampi Kirsi , Ruusunen Anu , Viinamäki Heimo , Koivumaa‐Honkanen Heli , Valkonen‐Korhonen Minna , Lehto Soili M. 
Published: June 2017

Recent evidence supports the association between healthy dietary patterns and a reduced risk of depression. The objective was: (1) to examine the associations between dietary patterns and alexithymic features; and (2) investigate whether these possible associations are explained by depressive symptoms in a cross‐sectional study among the Finnish general population aged 25–65 years. The study population was a part of the population‐based Kuopio Depression Study (KUDEP) conducted in central‐eastern Finland (n = 1747). Dietary data were collected using a food frequency questionnaire and dietary patterns from 22 predefined food groups, which were extracted by factor analysis. Alexithymia was assessed using the 20‐item Toronto Alexithymia Scale (TAS‐20) and depression using the 21‐item Beck Depression Inventory (BDI‐21). Altogether, 173 of the study subjects (9.9%) were alexithymic. Three dietary patterns were identified: “prudent,” “Western” and “traditional.” Lower scores for a healthy prudent dietary pattern and higher scores for an unhealthy Western dietary pattern were associated with an increased likelihood of belonging to the alexithymic group among subjects with elevated depressive symptoms. Among subjects without depressive symptoms, alexithymia was associated with lower scores in the prudent dietary pattern, but also with higher scores in the traditional dietary pattern. General population subjects with alexithymic features may have unhealthier dietary patterns than non‐alexithymic subjects.
Babesiosis: An unusual cause of sepsis after kidney transplantation and review of the literature
Authors: Ather Imtiaz , Pourafshar Negiin , Schain Denise , Gupte Asmita , Casey Michael J. 
Published: June 2017

AbstractWe report a unique case of babesiosis presenting as sepsis after kidney transplantation. A 70‐year‐old female kidney transplant recipient presented with fever, hemolytic anemia, and acute kidney injury, and met three of four systemic inflammatory response syndrome criteria. Serology was positive for Babesia microti, confirmed by polymerase chain reaction. The patient was treated with atovaquone and azithromycin and made a full recovery. Reports of babesiosis after solid organ transplantation are rare, with only four prior cases reported in the literature. We report the first case of babesiosis, to our knowledge, presenting as sepsis that was successfully treated after solid organ transplantation.
microRNAs involved in auxin signalling modulate male sterility under high‐temperature stress in cotton (Gossypium hirsutum)
Authors: Ding Yuanhao , Ma Yizan , Liu Nian , Xu Jiao , Hu Qin , Li Yaoyao , Wu Yuanlong , Xie Sai , Zhu Longfu , Min Ling , Zhang Xianlong 
Published: June 2017

SummaryMale sterility caused by long‐term high‐temperature (HT) stress occurs widely in crops. MicroRNAs (miRNAs), a class of endogenous non‐coding small RNAs, play an important role in the plant response to various abiotic stresses. To dissect the working principle of miRNAs in male sterility under HT stress in cotton, a total of 112 known miRNAs, 270 novel miRNAs and 347 target genes were identified from anthers of HT‐insensitive (84021) and HT‐sensitive (H05) cotton cultivars under normal‐temperature and HT conditions through small RNA and degradome sequencing. Quantitative reverse transcriptase‐polymerase chain reaction and 5′‐RNA ligase‐mediated rapid amplification of cDNA ends experiments were used to validate the sequencing data. The results show that miR156 was suppressed by HT stress in both 84021 and H05; miR160 was suppressed in 84021 but induced in H05. Correspondingly, SPLs (target genes of miR156) were induced both in 84021 and H05; ARF10 and ARF17 (target genes of miR160) were induced in 84021 but suppressed in H05. Overexpressing miR160 increased cotton sensitivity to HT stress seen as anther indehiscence, associated with the suppression of ARF10 and ARF17 expression, thereby activating the auxin response that leads to anther indehiscence. Supporting this role for auxin, exogenous Indole‐3‐acetic acid (IAA) leads to a stronger male sterility phenotype both in 84021 and H05 under HT stress. Cotton plants overexpressing miR157 suppressed the auxin signal, and also showed enhanced sensitivity to HT stress, with microspore abortion and anther indehiscence. Thus, we propose that the auxin signal, mediated by miRNAs, is essential for cotton anther fertility under HT stress.
Heterogeneous effects of trade liberalisation on firm‐level markups: Evidence from China
Authors: Xiang Xunyong , Chen Feixiang , Ho Chun‐Yu , Yue Wen 
Published: June 2017

AbstractThis paper analyses how trade liberalisation affects the markups of Chinese firms based on firm‐level production data, highly disaggregated transaction‐level product trade data and tariff data at the eight‐digit Harmonised System (HS) level. Our results show that there is a pro‐competition effect of output tariff reduction, that is decreasing output tariffs relate to a lower markup, and that there is a cost‐reduction effect of input tariff reduction, that is decreasing input tariffs relate to a higher markup. Interestingly, there are heterogeneous effects of trade liberalisation on firm‐level markups. The cost‐reduction effect of input tariff reduction is partially offset by the competition effect of new firm entry in more‐concentrated industries. Furthermore, there is a weaker effect of trade liberalisation on processing trade firms and state‐owned enterprises. Finally, our results are robust to the use of an instrumental variable approach to control for the endogeneity of tariffs and sample selection.
Faktor Penentu Amalan Kitar Semula Generasi Y Di Terengganu
Authors: Cheku Noor. H. , Mamat Ibrahim , Ibrahim Mohd Yusri 
Published: June 2017

Recycling campaign in Malaysia has failed because the practice of recycling among residents is still low. Thus, the Ministry of Housing and Local Government Malaysia has relaunched the campaign in 2001. Despite the high potential of recycling, only 10 per cent the amount of waste being recycled. This rate increased slowly, an increase of 5 percent over the past 12 years. This study aimed to investigate the relationship and the contribution of attitude towards recycle, environmental concerns and recycling practiced by Y generation in Terengganu. The respondents consisted of 338 students from seven institutions of higher education that represents Y generation for each district in the State. Questionnaire on environmental attitudes, environmental concerns and recycling practices was modified from previous studies and used as a research tool. Data were analyzed using SPSS 20. The findings showed that there was a significant relationship between the attitudes towards environment and practice of recycling (r = 0.80, sig = 0.00) and environmental concerns with the practice of recycling (r = 0.82, sig = 0.00). The findings also discovered that the environmental attitudes and the concern for the environment have contributed 72.2% to the practice of recycling. This study suggests a number of strategies to increase recycling practices.
Keberkesanan Permainan Persuasif Grafik Terhadap Perubahan Sikap Pemilihan Makanan Sihat Dalam Kalangan Murid-murid Tahun Dua
Authors: Esa Norlia Mat , Mailok Ramlah , Mohamad Yatim Maizatul Hayati 
Published: June 2017

This study aims to determine the effectiveness of persuasive graphic game as compared to game without persuasive graphic on the attitude change on selection of healthy foods among year two students. This study is a quasi-experimental with pre and post test for the non-equivalent group. The study sample comprised of 62 students consisting of 32 students in treatment group and 30 students in the control group. Analysing the data set using Analysis of Covariance (ANCOVA), the results indicate that the adjusted mean (79.90) of the persuasive graphic game is statistically significantly higher (F(1,57) = 16.63, p < .001) than the adjusted mean (73.70) of the non-persuasive graphic game. The obtained effect size (ES = +0.83), which is equivalent to approximately four fifth of a standard deviation, denotes the educational significance, favouring the persuasive graphic game group.
Characterising cis-regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues
Authors: Zhang Mingfeng , Lykke-Andersen Soren , Zhu Bin , Xiao Wenming , Hoskins Jason W , Zhang Xijun , Rost Lauren M , Collins Irene , Bunt Martijn van de , Jia Jinping , Parikh Hemang , Zhang Tongwu , Song Lei , Jermusyk Ashley , Chung Charles C , Zhu Bin , Zhou Weiyin , Matters Gail L , Kurtz Robert C , Yeager Meredith , Jensen Torben Heick , Brown Kevin M , Ongen Halit , Bamlet William R , Murray Bradley A , McCarthy Mark I , Chanock Stephen J , Chatterjee Nilanjan , Wolpin Brian M , Smith Jill P , Olson Sara H , Petersen Gloria M , Shi Jianxin , Amundadottir Laufey 
Published: June 2017

ObjectiveTo elucidate the genetic architecture of gene expression in pancreatic tissues.DesignWe performed expression quantitative trait locus (eQTL) analysis in histologically normal pancreatic tissue samples (n=95) using RNA sequencing and the corresponding 1000 genomes imputed germline genotypes. Data from pancreatic tumour-derived tissue samples (n=115) from The Cancer Genome Atlas were included for comparison.ResultsWe identified 38 615 cis-eQTLs (in 484 genes) in histologically normal tissues and 39 713 cis-eQTL (in 237 genes) in tumour-derived tissues (false discovery rate <0.1), with the strongest effects seen near transcriptional start sites. Approximately 23% and 42% of genes with significant cis-eQTLs appeared to be specific for tumour-derived and normal-derived tissues, respectively. Significant enrichment of cis-eQTL variants was noted in non-coding regulatory regions, in particular for pancreatic tissues (1.53-fold to 3.12-fold, p≤0.0001), indicating tissue-specific functional relevance. A common pancreatic cancer risk locus on 9q34.2 (rs687289) was associated with ABO expression in histologically normal (p=5.8×10−8) and tumour-derived (p=8.3×10−5) tissues. The high linkage disequilibrium between this variant and the O blood group generating deletion variant in ABO (exon 6) suggested that nonsense-mediated decay (NMD) of the ‘O’ mRNA might explain this finding. However, knockdown of crucial NMD regulators did not influence decay of the ABO ‘O’ mRNA, indicating that a gene regulatory element influenced by pancreatic cancer risk alleles may underlie the eQTL.ConclusionsWe have identified cis-eQTLs representing potential functional regulatory variants in the pancreas and generated a rich data set for further studies on gene expression and its regulation in pancreatic tissues.
VBS W±W±H production at the HL-LHC and a 100 TeV pp-collider
Authors: Englert Christoph , Li Qiang , Spannowsky Michael , Wang Mengmeng , Wang Lei 
Published: June 2017

[Formula: see text] production at hadron colliders through vector boson scattering is a so far unconsidered process, which leads to a clean signature of two same-sign charged leptons and two widely separated jets. This process is sensitive to the [Formula: see text] and [Formula: see text] couplings and any deviation of these couplings from their SM predictions serves as direct evidence of new physics beyond the SM. In this paper, we perform a Monte Carlo study of this process for the [Formula: see text] LHC and a 100 TeV [Formula: see text]-collider, and provide projections of the constraints on the triple-Higgs and [Formula: see text] quartic couplings for these environments. In particular, we consider the impact of pileup on the expected sensitivity in this channel. Our analysis demonstrates that although the sensitivity to the [Formula: see text] coupling is rather low, the [Formula: see text] coupling can be constrained in this channel within [Formula: see text][Formula: see text]100% and [Formula: see text][Formula: see text]20% at 95% confidence level around the SM prediction at the HL-LHC and a 100 TeV [Formula: see text]-collider, respectively. We have also provided results with simple truncation scheme, in consideration of unitarity safety.
Timing during transitions in Bengalese finch song: implications for motor sequencing
Authors: Troyer Todd W. , Brainard Michael S. , Bouchard Kristofer E. 
Published: June 2017

To investigate mechanisms of action sequencing, we examined the relationship between timing and sequencing of syllables in Bengalese finch song. An individual’s song comprises acoustically distinct syllables organized into probabilistic sequences: a given syllable potentially can transition to several different syllables (divergence points), and several different syllables can transition to a given syllable (convergence points). In agreement with previous studies, we found that more probable transitions at divergence points occur with shorter intersyllable gaps. One intuition for this relationship is that selection between syllables reflects a competitive branching process, in which stronger links to one syllable lead to both higher probabilities and shorter latencies for transitions to that syllable vs. competing alternatives. However, we found that simulations of competitive race models result in overlapping winning-time distributions for competing outcomes and fail to replicate the strong negative correlation between probability and gap duration found in song data. Further investigation of song structure revealed strong positive correlation between gap durations for transitions that share a common convergent point. Such transitions are not related by a common competitive process, but instead reflect a common terminal syllable. In contrast to gap durations, transition probabilities were not correlated at convergence points. Together, our data suggest that syllable selection happens early during the gap, with gap timing determined chiefly by the latency to syllable initiation. This may result from a process in which probabilistic sequencing is first stabilized, followed by a shortening of the latency to syllables that are sung more often. NEW & NOTEWORTHY Bengalese finch songs consist of probabilistic sequences of syllables. Previous studies revealed a strong negative correlation between transition probability and the duration of intersyllable gaps. We show here that the negative correlation is inconsistent with previous suggestions that timing at syllable transitions is governed by a race between competing alternatives. Rather, the data suggest that syllable selection happens early during the gap, with gap timing determined chiefly by the latency to syllable initiation.
Dynamic mechanisms of visually guided 3D motion tracking
Authors: Bonnen Kathryn , Huk Alexander C. , Cormack Lawrence K. 
Published: June 2017

The continuous perception of motion-through-depth is critical for both navigation and interacting with objects in a dynamic three-dimensional (3D) world. Here we used 3D tracking to simultaneously assess the perception of motion in all directions, facilitating comparisons of responses to motion-through-depth to frontoparallel motion. Observers manually tracked a stereoscopic target as it moved in a 3D Brownian random walk. We found that continuous tracking of motion-through-depth was selectively impaired, showing different spatiotemporal properties compared with frontoparallel motion tracking. Two separate factors were found to contribute to this selective impairment. The first is the geometric constraint that motion-through-depth yields much smaller retinal projections than frontoparallel motion, given the same object speed in the 3D environment. The second factor is the sluggish nature of disparity processing, which is present even for frontoparallel motion tracking of a disparity-defined stimulus. Thus, despite the ecological importance of reacting to approaching objects, both the geometry of 3D vision and the nature of disparity processing result in considerable impairments for tracking motion-through-depth using binocular cues. NEW & NOTEWORTHY We characterize motion perception continuously in all directions using an ecologically relevant, manual target tracking paradigm we recently developed. This approach reveals a selective impairment to the perception of motion-through-depth. Geometric considerations demonstrate that this impairment is not consistent with previously observed spatial deficits (e.g., stereomotion suppression). However, results from an examination of disparity processing are consistent with the longer latencies observed in discrete, trial-based measurements of the perception of motion-through-depth.
Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes
Authors: Fleuren Emmy D.G. , Vlenterie Myrella , van der Graaf Winette T.A. , Hillebrandt-Roeffen Melissa H.S. , Blackburn James , Ma Xiuquan , Chan Howard , Magias Mandy C. , van Erp Anke , van Houdt Laurens , Cebeci Sabri A.S. , van de Ven Amy , Flucke Uta E. , Heyer Erin E. , Thomas David M. , Lord Christopher J. , Marini Kieren D. , Vaghjiani Vijesh , Mercer Tim R. , Cain Jason E. , Wu Jianmin , Versleijen-Jonkers Yvonne M.H. , Daly Roger J. 
Published: June 2017

Abstract
Despite intensive multimodal treatment of sarcomas, a heterogeneous group of malignant tumors arising from connective tissue, survival remains poor. Candidate-based targeted treatments have demonstrated limited clinical success, urging an unbiased and comprehensive analysis of oncogenic signaling networks to reveal therapeutic targets and personalized treatment strategies. Here we applied mass spectrometry–based phosphoproteomic profiling to the largest and most heterogeneous set of sarcoma cell lines characterized to date and identified novel tyrosine phosphorylation patterns, enhanced tyrosine kinases in specific subtypes, and potential driver kinases. ALK was identified as a novel driver in the Aska-SS synovial sarcoma (SS) cell line via expression of an ALK variant with a large extracellular domain deletion (ALKΔ2–17). Functional ALK dependency was confirmed in vitro and in vivo with selective inhibitors. Importantly, ALK immunopositivity was detected in 6 of 43 (14%) of SS patient specimens, one of which exhibited an ALK rearrangement. High PDGFRα phosphorylation also characterized SS cell lines, which was accompanied by enhanced MET activation in Yamato-SS cells. Although Yamato-SS cells were sensitive to crizotinib (ALK/MET-inhibitor) but not pazopanib (VEGFR/PDGFR-inhibitor) monotherapy in vitro, synergistic effects were observed upon drug combination. In vivo, both drugs were individually effective, with pazopanib efficacy likely attributable to reduced angiogenesis. MET or PDGFRα expression was detected in 58% and 84% of SS patients, respectively, with coexpression in 56%. Consequently, our integrated approach has led to the identification of ALK and MET as promising therapeutic targets in SS. Cancer Res; 77(16); 4279–92. ©2017 AACR.
Homeobox Transcription Factor NKX2-1 PromotesCyclin D1Transcription in Lung Adenocarcinomas
Authors: Harada Masanori , Sakai Satoshi , Ohhata Tatsuya , Kitagawa Kyoko , Mikamo Masashi , Nishimoto Koji , Uchida Chiharu , Niida Hiroyuki , Kotake Yojiro , Sugimura Haruhiko , Suda Takafumi , Kitagawa Masatoshi 
Published: June 2017

AbstractThe known oncogene cyclin D1 (CCND1) participates in progression of the cell cycle from G1 to S-phase. Expression of cyclin D1 is frequently promoted in multiple human cancers including non–small cell lung cancer (NSCLC). However, a relationship between cyclin D1 expression and the prognosis of NSCLC has not been confirmed. NKX2-1 is a homeobox transcription factor involved in pulmonary development as a differentiation-promoting factor. In NSCLC, it acts as a metastasis suppressor and correlates with a good prognosis. Here, NKX2-1–binding motifs were identified in the cyclin D1 promoter, but it has not been clarified whether NKX2-1 is involved in cyclin D1 expression in NSCLC. To shed light on this issue, endogenous NKX2-1 was depleted in NSCLC cell lines, which resulted in decreased cyclin D1 mRNA and protein. In contrast, forced overexpression of NKX2-1 increased cyclin D1 levels. Moreover, NKX2-1 directly bound to the cyclin D1 promoter and enhanced its activity. Finally, using human NSCLC clinical specimens, it was determined that both NKX2-1 protein and mRNA were significantly correlated with cyclin D1 expression status in adenocarcinomas. These results indicate that NKX2-1 directly and positively regulates transcription of cyclin D1. Finally, expression of NKX2-1, but not cyclin D1, was significantly associated with metastatic incidence as an independent good prognostic factor of adenocarcinoma.Implications: NKX2-1–expressing adenocarcinomas, whereas NKX2-1 promoted cyclin D1 expression, may show good prognosis features by the metastasis inhibition potency of NKX2-1 regardless cyclin D1 expression. Mol Cancer Res; 15(10); 1388–97. ©2017 AACR.
Evaluation of Eight Current Reanalyses in Simulating Land Surface Temperature from 1979 to 2003 in China
Authors: Zhou Chunlüe , Wang Kaicun , Ma Qian 
Published: June 2017

Abstract
Land surface temperature Ts provides essential supplementary information to surface air temperature, the most widely used metric in global warming studies. A lack of reliable observational Ts data makes assessing model simulations difficult. Here, the authors first examined the simulated Ts of eight current reanalyses based on homogenized Ts data collected at ~2200 weather stations from 1979 to 2003 in China. The results show that the reanalyses are skillful in simulating the interannual variance of Ts in China (r = 0.95) except over the Tibetan Plateau. ERA-Interim and MERRA land versions perform better in this respect than ERA-Interim and MERRA. Observations show that the interannual variance of Ts over the north China plain and south China is mostly influenced by surface incident solar radiation Rs, followed by precipitation frequency, whereas the opposite is true over the northwest China, northeast China, and the Tibetan Plateau. This variable relationship is well captured by ERA-Interim, ERA-Interim land, MERRA, and JRA-55. The homogenized Ts data show a warming of 0.34°C decade−1 from 1979 to 2003 in China, varying between 0.25° and 0.42°C decade−1 for the eight reanalyses. However, the reanalyses substantially underestimate the warming trend of Ts over northwest China, northeast China, and the Tibetan Plateau and significantly overestimate the warming trend of Ts over the north China plain and south China owing to their biases in simulating the Rs and precipitation frequency trends. This study provides a diagnostic method for examining the capability of current atmospheric/land reanalysis data in regional climate change studies.