bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydropower reservoir sediment and water quality assessment
Authors: Estigoni Marcus Vinicius , Miranda Renato Billia , Mauad Frederico Fabio 
Published: December 2016

Purpose
Finer sediment particles (silt and clay) transported by rivers carry the major part of nutrient loads by absorption; thus, sediment settling can remove nutrients from the water column. The purpose of this paper is to analyze the relation between reservoir sedimentation and water quality by assessing the reservoir sedimentation process and the sediments’ characteristics.

Design/methodology/approach
Bathymetric surveys from 2004 to 2014 were analyzed to assess the sedimentation process. Core samples provided information on a layer-by-layer basis of the sediment deposits, and water samples near the surface and near the bottom provided information on sediment concentration, and adsorbed and dissolved nutrients.

Findings
The upstream region of a reservoir is already silted. From 2004 to 2014, the delta evoluted approximately 500 m downstream and the deposits were mainly composed of clay. An area of approximately 1,000 m between the delta and the dam should still be able to continue allowing sediment deposition in the coming years. Most of the nutrients were absorbed into the sediment particles, except for the nitrogen measured in the dry season.

Research limitations/implications
Although analyses of the full cycle of the nutrients were not carried out, the constant sediment trapping of finer sediments and the high rate of absorbed nutrients in the suspended sediment support the hypothesis that the reservoir has removed nutrients from aqueous media by adsorption into sediments.

Practical implications
In the studied case, reservoir sedimentation has led to better water quality downstream.

Originality/value
It is shown in this study that reservoir sedimentation may have positive effects on river water quality.
Valuing the Redevelopment Option Component of Urban Land Values
Authors: Munneke Henry J. , Womack Kiplan S. 
Published: December 2016

AbstractThis study draws from the redevelopment, real option, and urban spatial growth literatures to explore the spatial dynamics of the components of house prices. More specifically, the paper proposes that the capitalized value of the option to redevelop housing at the property level can be estimated by incorporating the likelihood of exercising the redevelopment option (the probability of redevelopment) into spatial and nonspatial hedonic house price models. Accordingly, option values are estimated for properties across the spectrum of the housing life cycle. Results from the study reveal a substantial level of spatial variation and clustering in the predicted option values, indicating that location is a major determinant of redevelopment and real option values. Furthermore, the results provide new evidence in support of the theoretical construct that properties purchased for immediate redevelopment are only valued for the underlying land.
Peritoneal Dialysis Registry With 2013 Survey Report
Authors: Masakane Ikuto , Hasegawa Takeshi , Ogata Satoshi , Kimata Naoki , Nakai Shigeru , Hanafusa Norio , Hamano Takayuki , Wakai Kenji , Wada Atsushi , Nitta Kosaku 
Published: December 2016

AbstractSince 2009, the peritoneal dialysis (PD) registry has been carried out as part of the annual nationwide survey conducted by the Statistical Survey Committee of the Japanese Society for Dialysis Therapy with the cooperation of the Japanese Society for Peritoneal Dialysis. In this study, the current status of PD patients is reported on the basis of the results of the survey conducted at the end of 2013. The subjects were PD patients who lived in Japan and participated in the 2013 survey. Descriptive analysis was performed for various items including the current status of the combined use of PD and another dialysis method such as hemodialysis (HD) or hemodiafiltration (HDF), the method of exchanging dialysate, the use of an automated peritoneal dialysis (APD) machine, and the incidences of peritonitis and catheter exit‐site infection. From the results of the facility survey in 2013, the number of PD patients was 9392, a decrease of 122 from that in 2012. Among the entire dialysis patient population, 3.0% were PD patients, a decrease of 0.1%. Among the studied patients, 292 had a peritoneal catheter and underwent peritoneal lavage, 174 were started on PD in 2013 but introduced to other blood purification methods in 2013, and 1920 underwent both PD and another dialysis method such as HD or HDF. The percentage of patients who underwent PD and another dialysis method increased with the number of years on PD: <1 year, 3.5%; 1 to < 2 years, 8.4%; 2 to < 4 years, 15.3%; 4 to < 6 years, 27.1%; 6 to < 8 years, 39.3%; 8 to < 10 years, 47.1%; and ≥ 10 years, 57.5%. The percentage of PD patients for whom the dialysate was completely manually exchanged was 31.6%, whereas the percentages of PD patients who used a bag‐exchange device based on ultraviolet‐light irradiation and that based on thermal sterile joint systems were 52.1 and 14.9%, respectively. The mean incidence of peritonitis was 0.22 per patient per year (once per 54.5 patients per month). The mean incidence of catheter exit‐site infection was 0.34 per patient per year (once per 35.3 patients per month).
Interleukin‐4 cytokine single nucleotide polymorphisms in kawasaki disease: a case‐control study and a review of knowledge
Authors: Assari Raheleh , Aghighi Yahya , Ziaee Vahid , Sadr Maryam , Rezaei Arezou , Rahmani Farzaneh , Sadr Zeinab , Raeeskarami Seyed Reza , Moradinejad Mohammad Hassan , Rezaei Nima 
Published: December 2016

AbstractAimKawasaki disease (KD) is a systemic vasculitis of medium‐sized arteries. High levels of interleukin 4 (IL‐4) and the dominance of Th2 cytokines seem to be a key feature in the acute phase of KD. In this study, the role of IL‐4 and IL‐4R gene polymorphisms were investigated in Iranian children with KD.MethodsFifty‐five patients with KD and 140 healthy subjects as a control group were enrolled in this study. Single nucleotide polymorphisms (SNPs) of IL‐4 gene at positions −1098 (rs2243248), −590 (rs2243250) and −33 (rs2070874), as well as IL‐4RA gene at position +1902 (rs180275) were assessed in patients and the control group.ResultsThe C allele and CC genotype of IL‐4 gene at position −590 and at position −33 had positive associations and the CT genotype at −590 was negatively associated with KD (odds ratio (95% CI) = 0.04 [0.01–0.09]). The haplotype TCC was more frequent among the patients, while the haplotypes TTT and TTC had a negative association with KD.ConclusionIL‐4 polymorphisms might be associated with KD in an Iranian population.
Identifying barriers to the care of the rheumatoid hand in China: comparing attitudes of rheumatologists and hand surgeons
Authors: Franzblau Lauren E. , Wang Keming , Liang Xuebing , Guo Yang , Li Yingni , Lin Yu‐chieh (Jay) , Lee Sunghee , Pennell Beth‐Ellen , Shauver Melissa J. , Chung Kevin C. 
Published: December 2016

AbstractAimIn China, hand surgeons treat fewer rheumatoid arthritis (RA) patients compared to other countries. We investigated whether physician and surgeon knowledge, attitudes and practices regarding RA hand deformities reflect current evidence and may contribute to the low utilization of surgery.MethodWe surveyed hand surgeons and rheumatologists at three tertiary hospitals in Beijing, China. Questionnaires were developed from literature and expert review to assess their knowledge, attitudes and practice patterns related to rheumatoid hand surgery.ResultsThirty‐five hand surgeons and 59 rheumatologists completed the survey. Roughly one‐third felt that the rheumatologists and hand surgeons agree on how to manage RA hand deformities. One‐fifth of rheumatologists and 29% of hand surgeons believed that drug therapy can correct hand deformities, which contradicts current evidence. Likewise, 30% and 14%, respectively, recommended surgery for early‐stage hand sequelae that do not meet current indications for surgery. Over 80% of surgeons and rheumatologists had no exposure to the other specialty during training and felt their training on the treatment of rheumatoid hand deformities was inadequate.ConclusionAlthough we found similar interspeciality disagreement in China as is seen in the United States, there appears to be less interaction through training and consultations. Our results also indicate potential deficits in training and unawareness of evidence and indications for rheumatoid hand surgery. These findings help to explain why surgery for rheumatoid hand deformities is rare in China; doctors have fewer opportunities to collaborate across specialties and may not be able to select appropriate candidates for surgery.
The Age‐Varying Association of Student Status with Excessive Alcohol Use: Ages 18 to 30 Years
Authors: Evans‐Polce Rebecca J. , Maggs Jennifer L. , Staff Jeremy , Lanza Stephanie T. 
Published: December 2016

BackgroundThere is a well‐known link between attending college and engaging in excessive alcohol use. This study examines in a national sample how the association between student status and excessive alcohol use changes from late adolescence through young adulthood and whether the association of student status with excessive alcohol use is different for students residing with versus away from parents during the school year.MethodsThis study used cross‐sectional data from the National Epidemiologic Survey on Alcohol and Related Conditions, a nationally representative sample of noninstitutionalized civilian adults residing in the United States. Our analyses included nonhigh school young adults who were ages 18 to 30 years (n = 8,645). Excessive alcohol use included past‐year (i) high‐intensity drinking (men: ≥10 standard drinks; women: ≥8) and (ii) exceeding weekly drinking guidelines (men: >14 drinks per week; women: >7). Students who resided away from their parents and students who lived with their parents during the school year were compared to nonstudents.ResultsAnalyses using time‐varying effect modeling showed that the relationship of student status with excessive alcohol use varied as a function of age. Overall student status lost its association with excessive alcohol use in the early 20s, after controlling for demographics and other adult social roles. The association between student status and excessive alcohol use also varied considerably across age and depending on whether the student was residing with or away from parents.ConclusionsThe association of student status with excessive alcohol use is heterogeneous in terms of both age and living arrangements, suggesting opportunities for interventions targeting problematic alcohol use. Future research should examine additional sources of heterogeneity of students in their risk for excessive alcohol use.
Elevated tumour necrosis factor‐alpha was associated with intima thickening in obese children
Authors: Bo Luo , Yi‐Can Yang , Qing Zhou , Xiao‐Hui Wu , Ke Huang , Chao‐Chun Zou 
Published: December 2016

AbstractAimThis study investigated the relationship between intima‐media thickness (IMT) and immune parameters in obese children from five to 16 years of age.MethodsWe enrolled 185 obese children with a mean age of 10.65 ± 2.10 years and 211 controls with a mean age of 10.32 ± 1.81 years. Glycometabolism, lipid metabolism, sex hormones, immune indices and carotid IMT were measured.ResultsSerum interleukin (IL)‐6, IL‐10, tumour necrosis factor (TNF)‐alpha, white blood cells and common and internal carotid artery IMTs in the obese group were higher than those in the control group (p < 0.05, respectively). Bivariate correlation analysis showed that the common carotid arterial IMT was positively correlated with alanine aminotransferase, triglyceride, uric acid, apolipoprotein B, IL‐6, IL‐10, TNF‐alpha, follicle‐stimulating hormone and testosterone. Internal carotid artery IMT was positively correlated with alanine aminotransferase and follicle‐stimulating hormone. Both common and internal carotid artery IMTs were inversely correlated with apolipoprotein A1 (p < 0.05, respectively). Stepwise multiple regression analysis showed that testosterone, alanine aminotransferase and TNF‐alpha were the independent determinants of common carotid arterial IMT.ConclusionTumour necrosis factor‐alpha, alanine aminotransferase and testosterone were associated with intima thickening in the early life in obese children and may increase later risks of premature atherogenicity and adult cardio‐cerebrovascular diseases.
High salivary testosterone‐to‐androstenedione ratio and adverse metabolic phenotypes in women with polycystic ovary syndrome
Authors: Münzker J. , Lindheim L. , Adaway J. , Trummer C. , Lerchbaum E. , Pieber T.R. , Keevil B. , Obermayer‐Pietsch B. 
Published: December 2016

SummaryBackgroundPolycystic ovary syndrome (PCOS) is characterized by a combination of hormonal and metabolic disturbances, such as insulin resistance, glucose intolerance, anovulation and hyperandrogenism. Clinical phenotypes of PCOS show different patterns of steroid hormones that have been investigated to some extent. This study aimed to establish a liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method for the quantification of salivary testosterone and androstenedione and to describe the salivary testosterone‐to‐androstenedione (T/A4) ratio as a new tool for the assessment of hyperandrogenism and metabolic health.Material and methodsSaliva and serum samples of 274 patients with PCOS and 51 healthy women were used for the quantification of steroid hormones. A comprehensive clinical and metabolic assessment was performed. Salivary testosterone and androstenedione were measured via LC‐MS/MS. The salivary T/A4 ratio was calculated and correlated with hormones and metabolic parameters.ResultsSalivary testosterone (P < 0·001), androstenedione (P < 0·001) and the salivary T/A4 ratio (P < 0·001) were significantly higher in patients with patients compared to healthy women. In patients with PCOS, a high salivary T/A4 ratio was associated with an adverse metabolic phenotype, that is glucose intolerance (P = 0·019), insulin resistance (P < 0·001), metabolic syndrome (P < 0·001), obesity (P < 0·001) and oligo‐/anovulation (P = 0·001). Significant correlations of the salivary T/A4 ratio with adverse metabolic parameters were found.ConclusionQuantification of salivary androgens provides an attractive alternative to serum analysis and helps in characterizing metabolic health in women with PCOS. Our data show a strong link between a high salivary T/A4 ratio and an adverse metabolic phenotype in patients with PCOS.
Hearing impairment in a female infant with interstitial deletion of 2q24.1q24.3
Authors: Ono Hiroaki , Kurosawa Kenji , Wakamatsu Nobuaki , Masuda Shin 
Published: December 2016

AbstractPatients with interstitial deletions in 2q24.1q24.3 are rarely reported. These patients manifest a variety of clinical features in addition to intellectual disability, depending on the size and location of the deletion. We report a female patient with interstitial deletion of 5.5 Mb in 2q24.1q24.3, who showed intrauterine growth retardation, hypotonia, global developmental delay, microcephaly, and characteristic facial appearance. In addition, she had hearing impairment, with no auditory brainstem response. Case of 2q24.1q24.3 deletion with hearing impairment is quite rare. We suspect that hearing impairment is caused by bilateral cochlear nerve deficiency due to cochlear nerve canal stenosis. Further studies are necessary to evaluate hearing impairment as a clinical feature in patients with de novo heterozygous 2q24.1q24.3 deletion.
Evaluating Agricultural Economists within Colleges and Faculties of Agriculture
Authors: Ker Alan P. 
Published: December 2016

There is an increasing tendency for individual faculty evaluations, in whole or in part, to be done outside the department. Historically, this was not true. College committees acted only to uphold standards, ensure equity, and monitor procedural correctness within a department's evaluation process. Deans tended not to participate in routine faculty evaluations. Financial metrics like return on investment were not calculated on an individual faculty basis. Incentives from all administrative levels tended to be consistent with disciplinary success. These are no longer true for many agricultural economics departments. Both department and faculty responses have been mixed. At the department level, some have not responded while others have embraced a life science model. At the individual faculty level, some have not responded while others have chased money, impact factors, and publication counts. I explore the consequences of these changes for agricultural economists in a college dominated by life sciences with two caveats. First, this is an opinion article and represents my perceptions of general tendencies; there exist many exceptions in either direction. Second, I have biases which are undoubtedly reflected throughout.Il y a une tendance croissante aux évaluations individuelles des professeurs, en tout ou en partie. Ces évaluations sont réalisées de l'extérieur du département. Historiquement, ce n′était pas vrai. Les comités des collèges agissaient uniquement pour respecter les normes, assurer l′équité et surveiller l'exactitude procédurale au sein du processus d′évaluation d'un département. Les doyens universitaires ont tendance à ne pas participer aux évaluations routines de la faculté académique. Les statistiques financières, comme le rendement du capital investi, n'ont pas été calculées individuellement au niveau de la faculté. Les mesures incitatives de tous les niveaux administratifs ont tendance à être liées avec la réussite dans le domaine en question. Ceci n'est plus vrai pour de nombreux départements d’économie agricoles universitaires. Les réponses des départements et du corps professoral ont été mitigées. Au niveau départemental, certains n'ont pas répondu alors que d'autres ont adopté le modèle des sciences de la vie. Au niveau de la faculté individuelle, certains n'ont pas répondu alors que d'autres ont chassé de l'argent, des facteurs d'impact et une quantité de publication. J'explore les conséquences de ces changements pour les économistes agricoles dans un collège dominé par les sciences de la vie. Je souligne deux mises en garde. Premièrement, il s'agit d'un article d'opinion et représente ma perception des tendances générales; Il existe de nombreuses exceptions dans les deux directions. Deuxièmement, j'ai des préjugés qui seront reflétés tout au long.
Why do patients die after a liver transplantation?
Authors: Daniel Kim E. , Eickhoff Jens , Lucey Michael R. 
Published: December 2016

AbstractBackgroundAs more patients achieve long‐term survival, it has become important to understand mortality in liver transplantation (LT) recipients.MethodsWe conducted retrospective reviews of long‐term outcome in two adult LT cohorts: 85 031 in the United Network for Organ Sharing (UNOS) database and 1458 transplanted at the University of Wisconsin (UW).ResultsDuring median follow‐up of 3.2 years (UNOS) and 6.6 years (UW), 35.1% of UNOS patients and 44.2% of UW patients died; 43.1% of all UNOS deaths occurred in year 1 compared to 25.1% in the UW cohort. Deaths due to infection (other than viral hepatitis) or cardiovascular (CV) causes were most frequent in year 1 in both cohorts and then persisted at lower rates. In contrast, death from malignancy increased after year 1 to peak in years 1‐5. Deaths due to rejection, hepatitis, or graft failure were infrequent. In the UW cohort, de novo malignancy was more common than recurrent tumor and correlated with smoking history.ConclusionsA coordinated holistic approach that focuses on limiting immunosuppression, infection, risky behaviors, and CV risks, while screening for cancer, is needed to extend the healthy lives of LT recipients.
Impact of physical activity on cardiovascular status in obesity
Authors: Lind Lars , Carlsson Axel C. , Siegbahn Agneta , Sundström Johan , Ärnlöv Johan 
Published: December 2016

AbstractBackgroundWe have recently shown that being physically active (PA) counteracts, but not eliminates the increased risk of future cardiovascular disease in overweight and obese subjects. To investigate this further, we studied the impact of being normal weight, overweight and obese on multiple markers of subclinical cardiovascular disease in relation to physical activity.Materials and methodsAt age 70, 1016 subjects were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Being PA was defined as performing regular heavy exercise (self‐reported). According to body mass index (BMI)/PA groups, the participants were categorized as PA/normal weight (BMI < 25 kg/m2, n = 104), non‐PA/normal weight (n = 234), PA/overweight (BMI 25–29·9 kg/m2, n = 133), non‐PA/overweight (n = 295), PA/obese (BMI ≥ 30 kg/m2, n = 54) and non‐PA/obese (n = 169). Several different measurements of endothelial reactivity and arterial compliance (plethysmography and ultrasound), cartotid artery atherosclerosis and echocardiography were performed, and seven markers of coagulation/fibrinolysis were measured.ResultsPhysically active subjects with obesity showed impaired vasoreactivity in the forearm resistance vessels, increased left ventricular mass and impaired left ventricular systolic and diastolic functions, together with impaired coagulation/fibrinolysis when compared to PA/normal‐weight subjects (P < 0·05 to <0·001). The majority of these disturbances were seen also in PA/overweight subjects when compared to PA/normal‐weight subjects (P < 0·05 to <0·001).ConclusionsOur data provide additional support for the notion that an increased level of self‐reported physical activity does not fully eliminate the deleterious cardiovascular consequences associated with overweight and obesity.
Prognostic impact of CD5 expression in diffuse large B‐cell lymphoma in patients treated with rituximab‐EPOCH
Authors: Thakral Beenu , Medeiros L. Jeffrey , Desai Parth , Lin Pei , Yin C. Cameron , Tang Guilin , Khoury Joseph D. , Hu Shimin , Xu Jie , Loghavi Sanam , Hu Bei , Oki Yasuhiro , Li Shaoying 
Published: December 2016

AbstractObjectivesCD5‐positive (CD5+) diffuse large B‐cell lymphoma (DLBCL) represents 5%‐10% of all DLBCL cases, which has been associated with a poorer prognosis in patients treated with R‐CHOP. Prognostic impact of CD5 expression in patients with DLBCL treated with R‐EPOCH has not been evaluated.MethodsWe studied 130 patients with de novo DLBCL who received frontline R‐EPOCH therapy. The clinicopathologic features and overall survival (OS) were compared between patients with CD5+ and CD5‐ DLBCL. MYC, BCL2, and BCL6 rearrangements were examined by fluorescent in situ hybridization.ResultsSixteen (12.3%) of 130 DLBCLs were CD5+. Most clinicopathologic features including cell of origin and frequency of MYC, BCL2, and BCL6 rearrangements were similar between CD5+ and CD5− groups. Patients with CD5+ DLBCL, however, showed higher rate of central nervous system relapse (33.3% vs 15.6%; P<.01) and a higher Ki67 proliferative index compared with CD5‐ patients. The median OS was significantly worse in CD5+ than CD5‐ patients (28.13 months vs not reached, P=.006). CD5 expression was an independent prognostic factor for OS in multivariate analysis.ConclusionsR‐EPOCH therapy does not seem to impact the known poorer prognosis of patients with de novo CD5+ DLBCL, and CD5 expression was still an independent prognostic factor in R‐EPOCH‐treated patients with DLBCL.