bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Fixation Technique on Continuous Interscalene Nerve Block Catheter Success: A Randomized, Double-Blind Trial
Authors: Auyong David B. , Cantor David Asher , Green Cynthia , Hanson Neil A. 
Published: February 2017

BACKGROUND:
Continuous peripheral nerve blocks offer advantages over single-injection blocks, including extended analgesia and reduction in opioid consumption. These benefits require that the perineural catheter remain intact for the duration of the planned local anesthetic infusion. Mechanical displacement of catheters, leaking, and consequent failure are known complications. The aim of this study was to evaluate continuous perineural catheter tip-to-nerve apposition in vivo over 48 hours comparing 2 different simple fixation strategies.

METHODS:
Subjects presenting for a continuous interscalene nerve block were randomized to perineural catheter fixation with 1 of 2 types of adhesive: Dermabond (2-octylcyanoacrylate) or Mastisol (alcohol 23A, gum mastic, storax, and methyl salicylate), covered with a simple transparent dressing. The primary outcome was the evaluation of catheter-to-nerve apposition maintenance over 48 hours via both a blinded ultrasound evaluation of local anesthetic distribution and a blinded clinical assessment. Secondary outcomes included leakage at the catheter site, pain scores, opioid consumption, catheter-to-skin migration at the insertion site, and patient satisfaction.

RESULTS:
Sixty-six subjects were recruited and randomized to compare adhesive group catheter tip-to-nerve apposition on postoperative day 2 (POD 2). Within the intention-to-treat cohort, a statistically significant decrease of perineural catheter tip-to-nerve apposition in the Mastisol group (64.7%) compared with the Dermabond group (90.6%) on POD 2 (odds ratios [OR] 0.19; 95% confidence interval [CI] 0.05–0.75; P = .012) was observed. Similar results were observed on POD 1 (OR 0.19; 95% CI 0.03–1.38; P = NS) and POD 2 (OR 0.14; 95% CI 0.02–0.97; P = .008) within the as-treated cohort. Catheter leakage (OR 67; 95% CI 7.3–589) and median catheter migration difference at the skin insertion site (2.0 cm; 95% CI 0.5–2.5) were also significantly greater in the Mastisol group than in the Dermabond group from POD 0 to POD 2 (P < .001). Median postoperative opioid consumption difference in morphine equivalents (3.2 mg; 95% CI – 9.0 to 14.2) was not significantly different between the Dermabond and the Mastisol groups through POD 2 (P = .542).

CONCLUSIONS:
Perineural catheter fixation with Dermabond in continuous interscalene nerve block improves maintenance of catheter-to-nerve apposition when compared with Mastisol.
Epidemiology of Cardiac Arrest During Hospitalization for Delivery in Canada: A Nationwide Study
Authors: Balki Mrinalini , Liu Shiliang , León Juan Andrés , Baghirzada Leyla 
Published: February 2017

BACKGROUND:
Cardiac arrest in pregnancy is a rare and devastating condition with high mortality and morbidity. The objective of this study was to generate information about maternal cardiac arrest in Canada by examining the frequency, temporal incidence, associated conditions, potential etiologies, and survival rates.

METHODS:
This retrospective population-based study used hospitalization data from the discharge abstract database of the Canadian Institute for Health Information relating to obstetric deliveries in Canada from April 1, 2002, to March 31, 2015. The data were accessed through the Public Health Agency of Canada’s (PHAC) Canadian Perinatal Surveillance System. Cases of cardiac arrest were identified using the diagnostic and intervention codes from the International Statistical Classification of Diseases and the Canadian Classification of Health Interventions, respectively. Data on patient demographics, medical and obstetrical conditions, and potential etiologies of cardiac arrest were collected. Multivariable logistic regression analysis was used to identify conditions associated with cardiac arrest.

RESULTS:
There were 286 cases of maternal cardiac arrest among 3,568,597 hospitalizations for delivery during the 13-year period. A total of 204 (71.3%) women survived to hospital discharge (95% confidence interval, 65.7%–76.5%). There was no significant variation in the incidence of cardiac arrest or survival from arrest over time or across provinces. Among the pre-existing conditions, hypertensive disorders of pregnancy, gestational diabetes, malignancy, and diseases of the respiratory and nervous system were found to be significantly associated with cardiac arrest. Among the obstetrical conditions, placental abnormalities and polyhydramnios were associated with cardiac arrest. The common potential etiologies included postpartum hemorrhage, heart failure, amniotic fluid embolism, and complications of anesthesia.

CONCLUSIONS:
In this first Canadian study, the incidence of cardiac arrest during pregnancy was found to be 1:12,500 deliveries. The survival rate reported in our study is higher than reported previously in other countries. Our study findings contribute to better inform the development and implementation of policies and programs in an effort to prevent and manage this condition.
Study Design Rigor in Animal-Experimental Research Published in Anesthesia Journals
Authors: Hoerauf Janine M. , Moss Angela F. , Fernandez-Bustamante Ana , Bartels Karsten 
Published: February 2017

BACKGROUND:
Lack of reproducibility of preclinical studies has been identified as an impediment for translation of basic mechanistic research into effective clinical therapies. Indeed, the National Institutes of Health has revised its grant application process to require more rigorous study design, including sample size calculations, blinding procedures, and randomization steps. We hypothesized that the reporting of such metrics of study design rigor has increased over time for animal-experimental research published in anesthesia journals.

METHODS:
PubMed was searched for animal-experimental studies published in 2005, 2010, and 2015 in primarily English-language anesthesia journals. A total of 1466 publications were graded on the performance of sample size estimation, randomization, and blinding. Cochran–Armitage test was used to assess linear trends over time for the primary outcome of whether or not a metric was reported. Interrater agreement for each of the 3 metrics (power, randomization, and blinding) was assessed using the weighted κ coefficient in a 10% random sample of articles rerated by a second investigator blinded to the ratings of the first investigator.

RESULTS:
A total of 1466 manuscripts were analyzed. Reporting for all 3 metrics of experimental design rigor increased over time (2005 to 2010 to 2015): for power analysis, from 5% (27/516), to 12% (59/485), to 17% (77/465); for randomization, from 41% (213/516), to 50% (243/485), to 54% (253/465); and for blinding, from 26% (135/516), to 38% (186/485), to 47% (217/465). The weighted κ coefficients and 98.3% confidence interval indicate almost perfect agreement between the 2 raters beyond that which occurs by chance alone (power, 0.93 [0.85, 1.0], randomization, 0.91 [0.85, 0.98], and blinding, 0.90 [0.84, 0.96]).

CONCLUSIONS:
Our hypothesis that reported metrics of rigor in animal-experimental studies in anesthesia journals have increased during the past decade was confirmed. More consistent reporting, or explicit justification for absence, of sample size calculations, blinding techniques, and randomization procedures could better enable readers to evaluate potential sources of bias in animal-experimental research manuscripts. Future studies should assess whether such steps lead to improved translation of animal-experimental anesthesia research into successful clinical trials.
Severe Intraoperative Hyperglycemia Is Independently Associated With Postoperative Composite Infection After Craniotomy: An Observational Study
Authors: Gruenbaum Shaun E. , Toscani Laura , Fomberstein Kenneth M. , Ruskin Keith J. , Dai Feng , Qeva Ega , Rosa Giovanni , Meng Lingzhong , Bilotta Federico 
Published: February 2017

BACKGROUND:
Postoperative infection after craniotomy carries an increased risk of morbidity and mortality. Identification and correction of the risk factors should be prioritized. The association of intraoperative hyperglycemia with postoperative infections in patients undergoing craniotomy is inadequately studied.

METHODS:
A total of 224 patients were prospectively enrolled in 2 major medical centers to assess whether severe intraoperative hyperglycemia (SIH, blood glucose ≥180 mg/dL) is associated with an increased risk of postoperative infection in patients undergoing craniotomy. Arterial blood samples were drawn and analyzed immediately after anesthetic induction and again before tracheal extubation. The new onset of any type of infection within 7 days after craniotomy was determined.

RESULTS:
The incidence of new postoperative composite infection was 10% (n = 22) within the first week after craniotomy. Weight, sex, American Society of Anesthesiologists score, preoperative and/or intraoperative steroid use, and diabetes mellitus were not associated with postoperative infection. SIH was independently associated with postoperative infection (odds ratio [95% confidence interval], 4.17 [1.50–11.56], P = .006) after fitting a multiple logistic regression model to adjust for emergency surgery, length of surgery, and age ≥65 years.

CONCLUSIONS:
SIH is independently associated with postoperative new-onset composite infections in patients undergoing craniotomy. Whether prevention of SIH during craniotomy results in a reduced postoperative risk of infection is unknown and needs to be appraised by further study.
Enhancement of fracture healing in the rat, modulated by compounds that stimulate inducible nitric oxide synthase
Authors: Rajfer R. A. , Kilic A. , Neviaser A. S. , Schulte L. M. , Hlaing S. M. , Landeros J. , Ferrini M. G. , Ebramzadeh E. , Park S-H. 
Published: February 2017

ObjectivesWe investigated the effects on fracture healing of two up-regulators of inducible nitric oxide synthase (iNOS) in a rat model of an open femoral osteotomy: tadalafil, a phosphodiesterase inhibitor, and the recently reported nutraceutical, COMB-4 (consisting of L-citrulline, Paullinia cupana, ginger and muira puama), given orally for either 14 or 42 days.Materials and MethodsUnilateral femoral osteotomies were created in 58 male rats and fixed with an intramedullary compression nail. Rats were treated daily either with vehicle, tadalafil or COMB-4. Biomechanical testing of the healed fracture was performed on day 42. The volume, mineral content and bone density of the callus were measured by quantitative CT on days 14 and 42. Expression of iNOS was measured by immunohistochemistry.ResultsWhen compared with the control group, the COMB-4 group exhibited 46% higher maximum strength (t-test, p = 0.029) and 92% higher stiffness (t-test, p = 0.023), but no significant changes were observed in the tadalafil group. At days 14 and 42, there was no significant difference between the three groups with respect to callus volume, mineral content and bone density. Expression of iNOS at day 14 was significantly higher in the COMB-4 group which, as expected, had returned to baseline levels at day 42.ConclusionThis study demonstrates an enhancement in fracture healing by an oral natural product known to augment iNOS expression. Cite this article: R. A. Rajfer, A. Kilic, A. S. Neviaser, L. M. Schulte, S. M. Hlaing, J. Landeros, M. G. Ferrini, E. Ebramzadeh, S-H. Park. Enhancement of fracture healing in the rat, modulated by compounds that stimulate inducible nitric oxide synthase: Acceleration of fracture healing via inducible nitric oxide synthase. Bone Joint Res 2017:6:–97. DOI: 10.1302/2046-3758.62.BJR-2016-0164.R2.
Multicenter Evaluation of Cystatin C Measurement after Assay Standardization
Authors: Bargnoux Anne-Sophie , Piéroni Laurence , Cristol Jean-Paul , Kuster Nils , Delanaye Pierre , Carlier Marie-Christine , Fellahi Soraya , Boutten Anne , Lombard Christine , González-Antuña Ana , Delatour Vincent , Cavalier Etienne 
Published: February 2017

Abstract

BACKGROUND
Since 2010, a certified reference material ERM-DA471/IFCC has been available for cystatin C (CysC). This study aimed to assess the sources of uncertainty in results for clinical samples measured using standardized assays.

METHODS
This evaluation was performed in 2015 and involved 7 clinical laboratories located in France and Belgium. CysC was measured in a panel of 4 serum pools using 8 automated assays and a candidate isotope dilution mass spectrometry reference measurement procedure. Sources of uncertainty (imprecision and bias) were evaluated to calculate the relative expanded combined uncertainty for each CysC assay. Uncertainty was judged against the performance specifications derived from the biological variation model.

RESULTS
Only Siemens reagents on the Siemens systems and, to a lesser extent, DiaSys reagents on the Cobas system, provided results that met the minimum performance criterion calculated according to the intraindividual and interindividual biological variations. Although the imprecision was acceptable for almost all assays, an increase in the bias with concentration was observed for Gentian reagents, and unacceptably high biases were observed for Abbott and Roche reagents on their own systems.

CONCLUSIONS
This comprehensive picture of the market situation since the release of ERM-DA471/IFCC shows that bias remains the major component of the combined uncertainty because of possible problems associated with the implementation of traceability. Although some manufacturers have clearly improved their calibration protocols relative to ERM-DA471, most of them failed to meet the criteria for acceptable CysC measurements.
Cannabis Edibles: Blood and Oral Fluid Cannabinoid Pharmacokinetics and Evaluation of Oral Fluid Screening Devices for Predicting Δ9-Tetrahydrocannabinol in Blood and Oral Fluid following Cannabis Brownie Administration
Authors: Newmeyer Matthew N , Swortwood Madeleine J , Andersson Maria , Abulseoud Osama A , Scheidweiler Karl B , Huestis Marilyn A 
Published: February 2017

AbstractBACKGROUNDRoadside oral fluid (OF) Δ9-tetrahydrocannabinol (THC) detection indicates recent cannabis intake. OF and blood THC pharmacokinetic data are limited and there are no on-site OF screening performance evaluations after controlled edible cannabis.CONTENTWe reviewed OF and blood cannabinoid pharmacokinetics and performance evaluations of the Draeger DrugTest®5000 (DT5000) and Alere™ DDS®2 (DDS2) on-site OF screening devices. We also present data from a controlled oral cannabis administration session.SUMMARYOF THC maximum concentrations (Cmax) were similar in frequent as compared to occasional smokers, while blood THC Cmax were higher in frequent [mean (range) 17.7 (8.0–36.1) μg/L] smokers compared to occasional [8.2 (3.2–14.3) μg/L] smokers. Minor cannabinoids Δ9-tetrahydrocannabivarin and cannabigerol were never detected in blood, and not in OF by 5 or 8 h, respectively, with 0.3 μg/L cutoffs. Recommended performance (analytical sensitivity, specificity, and efficiency) criteria for screening devices of ≥80% are difficult to meet when maximizing true positive (TP) results with confirmation cutoffs below the screening cutoff. TPs were greatest with OF confirmation cutoffs of THC ≥1 and ≥2 μg/L, but analytical sensitivities were &lt;80% due to false negative tests arising from confirmation cutoffs below the DT5000 and DDS2 screening cutoffs; all criteria were &gt;80% with an OF THC ≥5 μg/L cutoff. Performance criteria also were &gt;80% with a blood THC ≥5 μg/L confirmation cutoff; however, positive OF screening results might not confirm due to the time required to collect blood after a crash or police stop. OF confirmation is recommended for roadside OF screening.ClinicalTrials.gov identification number: NCT02177513
Chemical Innovation in Plant Nutrition in a Historical Continuum from Ancient Greece and Rome until Modern Times
Authors: Antonkiewicz Jacek , Łabętowicz Jan 
Published: February 2017

Abstract
This monograph aims to present how arduously views on plant nutrition shaped over centuries and how the foundation of environmental knowledge concerning these issues was created. This publication also presents current problems and trends in studies concerning plant nutrition, showing their new dimension. This new dimension is determined, on one hand, by the need to feed the world population increasing in geometric progression, and on the other hand by growing environmental problems connected with intensification of agricultural production.
Are Future Chemistry Teachers Prepared to Perform Chemical Experiments at Primary and Secondary Schools?
Authors: Drozdíková Anna , Prokša Miroslav 
Published: February 2017

Abstract
Our contribution is devoted to study the ability of future chemistry teachers to organise pupils’ observation of chemical phenomena. In this article measuring of multi-level means is described, which should denote a readiness of probands to perform an observation during carrying out chemical experiment. It is based on the assumption that well-prepared observers are able to work actively and to propose alternative solutions, because of their deep understanding of a procedure. In next part of this article the results of a research carried out at Faculty of Natural Sciences in Bratislava are analysed. The research was also aimed to detect if students are prepared to perform chemical experiments without a risk that they will be confused by a procedure or different course of experiment as they had expected.
Innovative Educational Program for Biogas Production Carried Out at University of Hradec Králové (CZ) and at University of Opole (PL)
Authors: Loskot Jan , Smolík Marek , Hyšplerová Lidmila , Radocha Karol , Kříž Jan , Eminger Stanislav , Dołhańczuk-Śródka Agnieszka , Ziembik Zbigniew , Wacławek Maria 
Published: February 2017

Abstract
Recently, there is a growing pressure on a rapid construction of agricultural biogas plants, particularly in the Czech-Polish border region. It is an area with large expanses of agricultural land which can serve to supply biogas plants with biomass. This strategy should contribute to harmonize the common agricultural policy of the European Union. A need for qualified operators of these stations on this territory is also increasing. Therefore we first include a demonstration of an education program for students in the field of agricultural waste anaerobic fermentation and biogas production. We present here the first part of an innovative approach which we use in the teaching program “Physico-technical Measurements and Computer Technology” at the Faculty of Science at the University of Hradec Kralove and also in the education of internshipers from the Faculty of Natural Sciences and Technology at the University of Opole. There are requirements to fulfil labour market expectations and to make this subject more attractive for the students. Students’ theoretical and practical preparation constitutes a comprehensive source of knowledge and skills required in a real life job. Joined theoretical and practical knowledge gained by students, reinforced by the skills developed during task analysis followed by their solution, provides the future graduate higher quality abilities and better position in the labour market.
The Effect of Point Emitter Geometric Parameters on Dustfall
Authors: Wierzbińska Monika 
Published: February 2017

Abstract
In this paper, the modeling results are presented of point emitter geometric parameters determining the dispersion of dust pollution in the atmospheric air and finally also dustfall. The parameters include: the height and diameter of the emitter. Using the maps generated by “Ek100w” programme of Atmoterm company from Opole, Poland, an analysis of the PM10 dustfall value distribution on the analyzed area has been made. Fraction of dust - PM10 - was emitted from emitters of various working parameters. Three situations were analyzed: emission from a one-family (detached) building, from and industrial plant and from a power plant. Different heights and diameters for the above cases were analyzed. What results from the work, is that the mentioned parameters have a significant influence on the value of dustfall on the area surface at different distances from the emitter. With the increase of the height and diameter of the emitter, the values of dustfall decrease. The distance of the maximal values occurrence also increases. Results of similar analysis and available tools allow to design emission in practice, and thus allow a maximal limitation of ambient concentration of pollution and dustfall in areas especially exposed to industrial and superficial emission.
Determination of Ammonium Concentration in Post-Process Waters from Underground Coal Gasification
Authors: Cykowska Malwina , Bebek Małgorzata , Strugała-Wilczek Aleksandra 
Published: February 2017

Abstract
A flow injection analysis method for spectrophotometric determination of ammonium in waters produced during underground coal gasification (UCG) of lignite and hard coal was described. The analysis of UCG water samples is very difficult because of their very complicated matrix and colour. Due to a huge content of organic and inorganic substances and intensive colour of samples (sometimes yellow, quite often dark brown or even black), most analytical methods are not suitable for practical application. Flow injection analysis (FIA) is based on diffusion of ammonia through a hydrophobic gas permeable membrane from an alkaline solution stream into an acid-base indicator solution stream. Diffused ammonia causes a colour change of indicator solution, and ammonia is subsequently quantified spectrophotometrically at 590 nm wavelength. The reliability of the results provided by applied method was evaluated by checking validation parameters like accuracy and precision. Accuracy was evaluated by recovery studies using multiple standard addition method. Precision as repeatability was expressed as a coefficient of variation (CV).
The Comparison of Cellulolytic Activity of the Modified Soil Treated with Roundup
Authors: Krzyśko-Łupicka Teresa , Kręcidło Łukasz , Kręcidło Magdalena 
Published: February 2017

Abstract
The activity of soil microorganisms affects soil fertility and structure, what leads to satisfactory crop yields, thanks to changes in the decay of organic matter. Their activity may be impaired as a result of application by farmers both fertilizers and pesticides. The degradation of cellulosic biomass represents an important part of the carbon cycle within the biosphere. Cellulolitic microorganisms are responsible for this decomposition, as they produced the enzymes of the cellulase complex. The aim of the study was to compare the cellulolytic activity of soil with Roundup and modified using urea phosphate and / or manure. The pot experiment was conducted under laboratory conditions. The studied material was brown soil (pH of 5.5) fertilized with manure and/or urea phosphate. To each earthenware vase were fed 0.5 kg of the tested soil supplemented with 1% carboxymethyl cellulose. The cellulolytic activities of soil in different experimental variants were expressed in % of C using a colorimetric Petkov method. Modification of soil cellulolytic activity varied considerably depending on the additive manure and/or urea phosphate and Roundup. The lowest soil cellulolytic activity was observed in the presence of manure and urea phosphate, and the highest in the soil with manure and Roundup. The objects of Roundup independently of the other additives urea phosphate stimulate the activity of the cellulolytic microflora compared to objects containing only urea phosphate. The presence of manure in soil treated with Roundup clearly accelerated degradation of cellulose, what can be used in agriculture in the degradation of crop residues. The study shows that pesticides and fertilizers have a big impact on cellulolytic activity in soil. Changes in cellulolytic activity can be used as an ecological indicator of soil pollution level.