bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Glucuronidation Genotypes and Urinary NNAL Metabolic Phenotypes in Smokers
Authors: Chen Gang , Luo Shaman , Kozlovich Shannon , Lazarus Philip 
Published: May 2016

Abstract
Background: The most abundant and potent carcinogenic tobacco-specific nitrosamine in tobacco and tobacco smoke is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). In vivo, NNK is rapidly metabolized to both the (R)- and (S)-enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), which possesses similar carcinogenic properties as NNK. The major detoxification pathway for both NNAL enantiomers is glucuronidation by UDP-glucuronosyltransferase (UGT) enzymes including UGT2B10 and UGT2B17. The goal of the present study was to directly examine the role of UGT genotypes on urinary levels of NNAL glucuronides in smokers.
Methods: NNAL-N-Gluc, (R)-NNAL-O-Gluc, (S)-NNAL-O-Gluc, and free NNAL were simultaneously and directly quantified in the urine of smokers by LC/MS analysis. Genotypes were determined by TaqMan assay using genomic DNA.
Results: The functional knockout polymorphism in the UGT2B10 gene at codon 67 (Asp&gt;Tyr) was significantly (P &lt; 0.0001) associated with a 93% decrease in creatinine-adjusted NNAL-N-Gluc. The polymorphic whole-gene deletion of the UGT2B17 gene was associated with significant (P = 0.0048) decreases in the levels of creatinine-adjusted (R)-NNAL-O-Gluc, with a 32% decrease in the levels of urinary (R)-NNAL-O-Gluc/(S)-NNAL-O-Gluc among subjects with the UGT2B17 (*2/*2) genotype as compared to subjects with the UGT2B17 (*1/*1) genotype.
Conclusions: These results suggest that functional polymorphisms in UGT2B10 and UGT2B17 are associated with a reduced detoxification capacity against NNAL and may therefore affect individual cancer risk upon exposure to tobacco.
Impact: This is the first report to clearly demonstrate strong genotype–phenotype associations between both the UGT2B10 codon 67 Asp&lt;Tyr genotype and urinary NNAL-N-Gluc levels and between the UGT2B17 copy number variant and urinary (R)-NNAL-O-Gluc levels in smokers. Cancer Epidemiol Biomarkers Prev; 25(7); 1175–84. ©2016 AACR.
ХАРАКТЕРИСТИКА ПОРУШЕНЬ ЛІПІДНОГО ОБМІНУ У ПАЦІЄНТІВ З АРТЕРІАЛЬНОЮ ГІПЕРТЕНЗІЄЮ ТА МЕТАБОЛІЧНИМ СИНДРОМОМ
Authors: Ananʹyeva O. V. , Kazanzhy D. V. 
Published: May 2016

<p>Актуальність. Пацієнти з артеріальною гіпертензією (АГ) та метаболічним синдромом (МС) належать до групи високого кардіоваскулярного ризику та потребують активної модифікації усіх факторів ризику, насамперед дисліпідемії.</p>
ОСОБЛИВОСТІ МІНЕРАЛЬНОЇ ЩІЛЬНОСТІ КІСТКОВОЇ ТКАНИНИ У ХВОРИХ НА КОМОРБІДНУ ПАТОЛОГІЮ ОРГАНІВ ТРАВЛЕННЯ ОСІБ ЖІНОЧОЇ СТАТІ
Authors: Boyko T. V. , Lykhatsʹka H. V. , Lykhatsʹka V. O. , Boyko V. I. 
Published: May 2016

<p>Вступ. В останні роки проблема остеопорозу (ОП) набула особливого звучання внаслідок двох тісно пов’язаних демографічних процесів: різкого<br />збільшення в популяції старих людей і, відповідно, кількості жінок у постменопаузі. Приблизно в кожної третьої жінки після 65 років трапляється<br />один остеопоротичний перелом. Переломи стегнової кістки приводять до зменшення тривалості життя на 12−15 років. Хронічні запальні захворювання гастродуоденопанкреатичної зони і печінки супроводжуються зниженням абсорбції мінералів і вітаміну D в кишечнику, внаслідок чого знижується мінеральна щільність кісткової тканини (МЩКТ), що часто призводить до інвалідизації хворих.</p>
РОЛЬ ПЕРВИННОЇ ЛАНКИ У ПРОФІЛАКТИЦІ АРТЕРІАЛЬНОЇ ГІПЕРТЕНЗІЇ СЕРЕД ДОРОСЛОГО НАСЕЛЕННЯ
Authors: Boyko T. Ya. 
Published: May 2016

<p>Вступ. Як відомо, артеріальна гіпертензія (АГ) у структурі загальної захворюваності та смертності займає одне з провідних місць.<br />На АГ хворіє близько 25 % дорослого населення світу, поширеність АГ серед населення у світі, за прогнозами, у 2025 р. зросте до 1,5 млрд осіб<br />(ВООЗ). В Україні налічують майже 12 млн осіб із АГ, що становить близько 30 % дорослого населення. Окрім тяжких ускладнень з боку серцевосудинної, сечовидільної систем, гіпертензія є супутньою патологією при ожирінні, цукровому діабеті, атеросклерозі.</p>
ПОЗИТИВНИЙ ВПЛИВ ШРОТІВ НА ГІПЕРУРИКЕМІЮ ЯК СКЛАДОВИЙ КОМПОНЕНТ МЕТАБОЛІЧНОГО СИНДРОМУ
Authors: Garkusha S. L. 
Published: May 2016

<p>Цілий ряд проведених досліджень вказують на кореляцію між гіперурикемією (ГУ) та такими складовими частинами метаболічного синдрому (МС) як ожиріння (Ож), артеріальна гіпертензія (АГ), дисліпідемія (ДЛП), гіперглікемія (ГГ), інсу-<br />лінорезистентність (ІР), цукровий діабет (ЦД). ГУ розглядають як один з маркерів і водночас патогенетичних чинників розвитку ІР та ССЗ.</p>
ЗАСТОСУВАННЯ АПЛІКАТОРІВ ЛЯПКА У КОМПЛЕКСНІЙ ТЕРАПІЇ БОЛЬОВОГО СИНДРОМУ У ХВОРИХ НА ХРОНІЧНИЙ ПАНКРЕАТИТ
Authors: Zakharchuk U. M. , Babinets L. S. , Pidruchnyy M. S. 
Published: May 2016

<p>Вступ. Специфічний больовий синдром є одним із найхарактерніших проявів хронічного панкреатиту (ХП), який часто призводить до розвитку<br />цукрового діабету (ЦД). У світовій практиці з успіхом використовують альтернативні методи лікування. Метою нашого дослідження було оцінити<br />ефективність застосування поверхневої багатоголчастої різнометалевої аплікації у комплексній терапії больового синдрому хворих на ХП+ЦД.</p>
ВЗАЄМОЗВ'ЯЗОК ТРИВОЖНО-ДЕПРЕСИВНИХ РОЗЛАДІВ ЗІ СТУПЕНЕМ КОМПЕНСАЦІЇ ЦД 2 ТИПУ У ХВОРИХ НА ІХС
Authors: Melʹnyk A. I. , Zelenina O. O. 
Published: May 2016

<p>У пацієнтів з ЦД 2 типу та рівнем HbA1с≥6,5% спостерігається збільшення частоти і ступеня вираженості ТДР за шкалою HADS, які асоціюються з більш вираженими порушеннями<br />ліпідного спектра і зниженням якості життя за даними SAQ.</p>
ВПЛИВ КОМПЕНСАЦІЇ ЗАХВОРЮВАННЯ НА ВМІСТ РЕЗИСТИНУ У ХВОРИХ НА ЦУКРОВИЙ ДІАБЕТ 2 ТИПУ
Authors: Urbanovych A. M. 
Published: May 2016

<p>Дослідження, які ведуться із вісімдесятих років минулого століття, мають на<br />меті з’ясування ролі гормонів жирової тканини у патогенезі ЦД 2 типу та його ускладнень. Доведено, що низка біологічно активних сполук<br />жирової тканини, зокрема резистин, мають прозапальний потенціал, проте мало відомо про його взаємозв’язок із ступенем компенсації ЦД 2 типу.</p>
Autobiografía, identidad y memoria familiar. Apuntes sobre Conjeturas sobre la memoria de mi tribu de José Donoso
Authors: Lombardo Martín 
Published: May 2016

A partir de los desarrollos propuestos por Philippe Lejeune sobre el pacto y el espacio autobiográfico así como la reflexión de Agamben en torno a la creación y a la figura de la excepción, el presente artículo se propone analizar el libro Conjeturas sobre la memoria de mi tribu de José Donoso. En particular, el artículo centra su análisis en la manera en que se concibe el surgimiento de la figura del escritor, en la configuración de la identidad a través de la historia familiar y en la importancia del espacio familiar y del tiempo en la obra de Donoso.
Role of Radiative–Convective Feedbacks in Spontaneous Tropical Cyclogenesis in Idealized Numerical Simulations
Authors: Wing Allison A. , Camargo Suzana J. , Sobel Adam H. 
Published: May 2016

AbstractThe authors perform 3D cloud-resolving simulations of radiative–convective equilibrium (RCE) in a rotating framework, with interactive radiation and surface fluxes and fixed sea surface temperature. A tropical cyclone is allowed to develop spontaneously from a homogeneous environment, rather than initializing the circulation with a weak vortex or moist bubble (as is often done in numerical simulations of tropical cyclones). The resulting tropical cyclogenesis is compared to the self-aggregation of convection that occurs in nonrotating RCE simulations. The feedbacks leading to cyclogenesis are quantified using a variance budget equation for the column-integrated frozen moist static energy. In the initial development of a broad circulation, feedbacks involving longwave radiation and surface enthalpy fluxes dominate, which is similar to the initial phase of nonrotating self-aggregation. Mechanism denial experiments are also performed to determine the extent to which the radiative feedbacks that are essential to nonrotating self-aggregation are important for tropical cyclogenesis. Results show that radiative feedbacks aid cyclogenesis but are not strictly necessary.
Early Summer Response of the East Asian Summer Monsoon to Atmospheric CO2 Forcing and Subsequent Sea Surface Warming
Authors: Chen Jinqiang , Bordoni Simona 
Published: May 2016

Abstract
The early summer regional climate change of the East Asian summer monsoon (EASM) is investigated in the phase 5 of the Coupled Model Intercomparison Project (CMIP5) archive. In the greenhouse gas–forced scenario, reduction of radiative cooling and increase in continental surface temperature occur much more rapidly than changes in sea surface temperatures (SSTs). Without changes in SSTs, the early summer rainfall in the monsoon region decreases (increases) over ocean (land) in most models. On longer time scales, as SSTs increase, rainfall changes are opposite. The total response to atmospheric CO2 forcing and subsequent SST warming is a large (modest) increase in rainfall over ocean (land) in the EASM region. Dynamic changes, in spite of significant contributions from the thermodynamic component, play an important role in setting up the spatial pattern of precipitation changes. Early summer rainfall anomalies over east China are a direct consequence of local land–sea contrast, while changes in the large-scale oceanic rainfall band are closely associated with the displacement of the larger-scale North Pacific subtropical high (NPSH). Ad hoc numerical simulations with the AM2.1 general circulation model show that topography and SST patterns play an important role in early summer rainfall changes in the EASM region.
Forensic and Anthropological Application of Body Asymmetry: A Comment on Gutnik et al. (2015)
Authors: Krishan Kewal , Kanchan Tanuj 
Published: May 2016

The present communication describes the application of bilateral asymmetry in forensic casework and anthropological research. Bilateral asymmetry is normal in the human body. The body’s asymmetry is attributable to genetic and environmental (evolutionary) reasons. Handedness is a factor related to bilateral asymmetry. Gutnik et al. (2015) supported previous research, showing that the dominant side of the body is stronger than the other side due to additional stress and strain, and thus has augmented musculature and increased mass. The note is intended to elaborate on the applications of body asymmetry in forensic and anthropological practice.
Early Patient Satisfaction Results on a Modern Generation Fixed-Bearing Total Ankle Arthroplasty
Authors: Oliver Shelley M. , Coetzee J. Chris , Nilsson Lawrence J. , Samuelson Kathryn M. , Stone Rebecca M. , Fritz Jacquelyn E. , Giveans M. Russell 
Published: May 2016

Background: This study presents patient-reported outcomes and patient satisfaction data for the largest series of US patients undergoing modern fixed-bearing total ankle arthroplasty (TAA). Methods: We retrospectively reviewed the records of 300 consecutive patients who underwent 321 modern, fixed-bearing TAAs at a single institution. Veterans Rand 12-Item Health Survey (VR-12), Ankle Osteoarthritis Scale (AOS), and the American Orthopaedic Foot & Ankle Society (AOFAS) Hindfoot score were collected preoperatively and at subsequent follow-up appointments. A patient satisfaction survey was also distributed to each patient postoperatively. Of the 321 TAAs, 245 (232 patients) had a minimum of 2-year follow-up and a complete data set. Furthermore, 192 patients underwent concomitant procedures. The average follow-up was 38.9 months (24-84.5). Eight patients have been lost to follow-up (7 deceased and 1 refused further follow-up). Results: The mean AOFAS score preoperatively was 41.1 and at latest follow-up was 84.6 ( P < .01). The mean VR-12 score was 29.7 (Physical) and 54.1 (Mental) preoperatively and 42.7 (Physical) and 55.7 (Mental) at latest follow-up ( P < .01 and P > .05, respectively). AOS pain and disability scores improved significantly after TAA ( P < .01). The patient satisfaction survey indicated that 84% experienced very good to excellent pain relief, 78% reported improved ability to perform daily tasks, and 54% indicated improvement in their ability to perform heavy work or recreational activities. In addition, 94% would probably or definitely have the procedure on the contralateral ankle. Two patients underwent revision TAA at a minimum of 36 months; 8 patients failed the primary TAA and were converted to ankle fusions at a mean of 20.1 months (6.1-46.1). Conclusion: Early results of a large series of a modern TAA system demonstrate improvement in patient satisfaction, quality of life, activity, and pain for patients with end-stage ankle arthritis. Early revision was due to infection or loosening of the tibial component. Level of Evidence: Level IV, case series.
Effect of single and dual renin-angiotensin blockade on stroke in patients with and without diabetes in VALIANT
Authors: Abdul-Rahim Azmil H , Docherty Kieran F , Skali Hicham , Køber Lars , Dickstein Kenneth , Maggioni Aldo P , Mareev Viacheslav , Zannad Faiez , Velazquez Eric J , Califf Robert M , Pfeffer Marc A , Solomon Scott D , Lees Kennedy R , McMurray John JV 
Published: May 2016

Introduction Concern has been raised about a possible increase in risk of stroke in patients with diabetes treated with the combination of the renin-inhibitor aliskiren and an angiotensin converting enzyme inhibitor or angiotensin receptor blocker. We compared the rate of stroke in patients with and without diabetes treated with single or dual renin-angiotensin system blockade after acute myocardial infarction. Patients and methods We performed a post hoc analysis of the Valsartan in Acute Myocardial Infarction trial in which 14,703 patients with heart failure, left ventricular systolic dysfunction or both, were randomised to captopril (C), valsartan (V) or both (C + V) after 0.5–10 days after acute myocardial infarction and followed for a median of 2.1 years. We used Cox proportional-hazard regression to estimate the hazard ratios [HR (95% CI)] of stroke in each treatment group. Results Among patients with diabetes, 60/1303 (4.6%) receiving captopril, 60/1337 (4.5%) valsartan and 41/1340 (3.1%) valsartan plus captopril suffered a stroke: V + C versus V or C HR 0.68 (0.47–0.96), p = 0.03. The corresponding numbers in patients without diabetes were 106/3606 (2.9%), 97/3572 (2.7%) and 99/3545 (2.8%): V + C versus V or C HR 0.99 (0.78–1.26), p = 0.92 (interaction p = 0.08). Conclusion The risk of stroke after myocardial infarction in patients with diabetes was lower in patients treated with both an angiotensin converting enzyme inhibitor and angiotensin receptor blocker than in patients receiving either monotherapy.
Targeted Therapy for Metastatic Urothelial Cancer: A Work in Progress
Authors: Plimack Elizabeth R. , Geynisman Daniel M. 
Published: May 2016

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. A 64-year-old man presented to the clinic to discuss treatment options for progressive metastatic urothelial carcinoma (UC). At age 57 years, he underwent cystoprostatectomy for bacillus Calmette-Guérin–refractory, high-grade noninvasive UC. He was well until age 61 years, when he developed a left upper-tract UC. He underwent left nephroureterectomy, revealing locally advanced high-grade UC invading the renal parenchyma (pT3). Postoperatively, his renal function precluded adjuvant cisplatin-based chemotherapy. He enrolled onto a clinical trial of autologous cellular immunotherapy targeting human epidermal growth factor receptor 2, for which he was eligible on the basis of human epidermal growth factor receptor 2 positivity (≥ 1+ by immunohistochemistry) in his nephrectomy tumor specimen. He was randomly assigned to observation. Two years later, he developed a left pelvic mass. Biopsy confirmed metastatic high-grade UC. He was briefly treated with gemcitabine and carboplatin, but this was discontinued as a result of rapid symptomatic and radiographic progression at 8 weeks. He underwent palliative radiation to the left pelvic mass to relieve symptoms of pain and leg edema and subsequently elected to enroll onto a clinical trial of a programmed death 1 inhibitor. Concurrently, his previously obtained pelvic mass biopsy sample was sent for panel-based genomic profiling. He now returns for his first restaging evaluation. Imaging shows marked progression on study with new metastases to the liver as well as progressive edema and pain in the left leg, limiting ambulation. Review of his now-available genomic testing results reveals alterations in HRAS (G12D) and ATR (S296, Q257). He elected to enroll onto a single-arm, open-label trial of a farnesyl transferase inhibitor for patients with HRAS mutations.
pyGeno: A Python package for precision medicine and proteogenomics
Authors: Daouda Tariq , Perreault Claude , Lemieux Sébastien 
Published: May 2016

pyGeno is a Python package mainly intended for precision medicine applications that revolve around genomics and proteomics. It integrates reference sequences and annotations from Ensembl, genomic polymorphisms from the dbSNP database and data from next-gen sequencing into an easy to use, memory-efficient and fast framework, therefore allowing the user to easily explore subject-specific genomes and proteomes. Compared to a standaloneprogram, pyGeno gives the user access to the complete expressivity of Python, a general programming language. Its range of application therefore encompasses both short scripts and large scale genome-wide studies.
Optimization of the variables selection in the process of real estate markets rating
Authors: Renigier-Biłozor Małgorzata , Biłozor Andrzej 
Published: May 2016

The growing significance of the real estate market prompts investors to search for factors and variables which support cohesive analyses of real estate markets, market comparisons based on diverse criteria and determination of market potential. The specificity of the real estate market is determined by the unique attributes of property. The Authors assume that developing real estate market ratings identifies the types of information and factors which affect decision-making on real estate markets. The main objective of real estate market ratings is to create a universal and standardized classification system for evaluating the real estate market. One of the most important problems in this area is collecting appropriate features of real estate market and development dataset. The main problem involves the selection and application of appropriate features, which would be relevant to the specificity of information related to the real estate market and create a kind of coherent system aiding the decision-making process. The main aim of this study is the optimization of set of variables that were used to develop the real estate market ratings. For this purpose, Hellwig’s method of integral capacity of information was applied. In this particular case, the method shows what set of variables provides information most sufficiently. The results lead to obtaining the necessary set of features that constitute essential information which describes the situation on the local real estate market.
Review of hereditary angioedema
Authors: Fu Lisa W. , Freedman-Kalchman Tamlyn , Betschel Stephen , Sussman Gordon 
Published: May 2016

Hereditary angioedema (HAE) is a rare disease caused by deficiency of C1 esterase inhibitor (C1-INH). It is an autosomal dominant disease caused by a variety of mutations in the C1-INH gene. C1-INH is an important regulator of several pathways. One pathway it affects is the kallikrein–kinin pathway, which results in the generation of bradykinin. Bradykinin is an important mediator of edema. Diagnosis is based on low levels of C1-INH. HAE with normal C1-INH is also recognized in the literature and the pathophysiology is due to another aspect of the pathway being affected leading to increased bradykinin level. Bradykinin results in intermittent swelling of the cutaneous and mucosal surfaces. The swelling usually evolves over several hours and lasts a few days. Location of the swelling can involve any part of the body including fatal laryngeal edema. Newer treatments exist to treat acute attacks and reduce the frequency of future attacks. Earlier diagnosis and treatment of hereditary angioedema can prevent HAE-associated mortality. Statement of novelty: New treatments are used to treat these attacks. These treatments are aimed at patients having a more normal life with hereditary angioedema.
Epochenverschleppung als Innovationsfaktor
Authors: Malo Markus 
Published: May 2016

Zusammenfassung:
Die Einführung von RFID an Bibliotheken hat mittlerweile keinerlei Sensationswert mehr. Der Fokus dieses Beitrags liegt stattdessen auf der Einbettung der RFID-Einführung an der UB Stuttgart in ein strategisches Konzept, das konkrete universitäre Handlungs- und Problemfelder an der Universität Stuttgart benennt und in allgemeine Überlegungen zum strategischen Zukunftsmanagement eingebettet ist. Der methodische Ansatz des Verfassers ist dabei dem ursprünglichen Vortragscharakter des Beitrags bei einer Fortbildung des VDB Bayern zum Thema „10 Jahre RFID – Was hat sich bewährt, wie geht es weiter?“ geschuldet und eher feuilletonistischer Natur denn an wirtschaftswissenschaftlichen Methoden oder technischen Aspekten orientiert.
Sorption properties of sheep wool irradiated by accelerated electron beam
Authors: Hanzlíková Zuzana , Braniša Jana , Hybler Peter , Šprinclová Ivana , Jomová Klaudia , Porubská Mária 
Published: May 2016

AbstractElectron beam (EB) irradiated wool was examined for sorption of chromic ions. Sorption increased with the adsorbed dose non-monotonously, which is a result of the generation of S-oxidized groups, secondary structure variation, and the breaking of the keratin backbone. For a dose of 400 kGy, an increase by 120 % was observed at the cystine dioxide and cysteine acid amounts. Examining sorption of unexposed wool and that irradiated with doses of 25 kGy and 40 kGy for basic, methylene blue (MB), or acidic, pyrogallol red (PR) dyes revealed that such low doses have no effect on the carboxylic or amino groups of keratin. Sorption of MB is independent of the EB treatment and is identical for both samples due to the interaction of MB amino groups with the carboxylic groups of wool; however, the sorption capacity for PR is a function of the EB treatment. The sample irradiated with the dose of 25 kGy showed higher PR sorption than that with the EB dose of 40 kGy, which was equal to that of unexposed wool. While the 25 kGy sample provided more active sites for PR interaction compared with the unexposed one, the 40 kGy sample contained already enough active sites to generate intra- and intermolecular interactions inside wool. Thus, PR adherence to the 40 kGy sample was restricted and comparable to the level of unexposed wool.