bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Japanese version of the patient perceptions of deprescribing – Short form
Authors: Kushibuchi Mio , Ie Kenya , Takahashi Masaki , Linsky Amy M. , Albert Steven M. 
Published: October 2024

AbstractBackgroundDeprescribing is a critical component of clinical practice, especially in geriatric medicine. Nevertheless, the attributes of patients who are prepared for, interested in, and could potentially benefit from deprescribing have not been well examined. The Patient Perceptions of Deprescribing (PPoD) evaluates patients' overall readiness for deprescribing and is complemented by an 11‐item validated short form (SF‐PPoD). The objective of this study was to develop a Japanese version of the SF‐PPoD and assess its reliability and validity within Japanese older adults with polypharmacy.MethodsThe SF‐PPoD was translated, back‐translated, and assessed in a cognitive interview. We conducted a cross‐sectional survey with 196 patients aged 65 years or older with five or more medications using the Japanese version to test for reliability and validity. We examined internal consistency and construct validity to determine if the Japanese sample responses reproduce the two subscales in the original SF‐PPoD. Finally, we examined intra‐person replicability using the intraclass correlation coefficient, in which 100 participants were invited and 93 participated.Results118 males and 78 females, with a mean age of 79.2 [SD 6.5] years, completed the survey. Confirmatory factor analysis of the Japanese version of SF‐PPoD revealed satisfactory structural validity with two‐dimensional structure, “Motivation for Deprescribing” and “Primary Care Physician Relationship.” Cronbach's alpha showed good internal consistency, and test–retest demonstrated acceptable intra‐rater reliability.ConclusionsWe developed and validated a Japanese version of SF‐PPoD with an 11‐item, two‐dimensional structure consistent with the original SF‐PPoD. This scale may facilitate shared decision‐making for medication optimization among older adults living with multimorbidity.
On a conjecture that strengthens Kundu's k <math xmlns="http://www.w3.org/1998/Math/MathML" altimg="urn:x-wiley:03649024:media:jgt23177:jgt23177-math-0001" wiley:location="equation/jgt23177-math-0001.png"><mrow><mrow><mi>k</mi></mrow></mrow></math>‐factor theorem
Authors: Shook James M. 
Published: October 2024

AbstractLet be a nonincreasing degree sequence with even . In 1974, Kundu showed that if is graphic, then some realization of has a ‐factor. For , Busch et al. and later Seacrest for showed that if and is graphic, then there is a realization with a ‐factor whose edges can be partitioned into a ‐factor and edge‐disjoint 1‐factors. We improve this to any . In 1978, Brualdi and then Busch et al. in 2012, conjectured that . The conjecture is still open for . However, Busch et al. showed the conjecture is true when or . We explore this conjecture by first developing new tools that generalize edge‐exchanges. With these new tools, we can drop the assumption is graphic and show that if then has a realization with edge‐disjoint 1‐factors. From this we confirm the conjecture when or when is graphic and .
Shrimp allergy leading to severe transfusion reaction: A case report
Authors: Sonneveld Myrthe E. , Bernelot Moens Sophie J. , van den Akker Jolanda , Vos Josephine M. I. , Kwakernaak Arjan J. 
Published: October 2024

AbstractBackgroundTransfusion reactions occur at an estimated incidence of 2 per 1.000 transfused products. Anaphylactic transfusion reactions are rarer, and seen in 1 per 10.000 transfusions, and are mostly related to platelet transfusions. Here, we describe a rare cause of a transfusion reaction.Case presentationA 19‐year‐old man underwent an allogeneic haematopoietic stem cell transplantation for sickle cell disease and developed an anaphylactic shock following a platelet transfusion, after excluding all common causes. The patient reported a shrimp allergy, and one of the blood/platelet donors had consumed shrimp the day before donation. Elevated levels of specific immunoglobulin E (IgE) directed against shrimp and tropomyosin allergens were found in the patient. Subsequent transfusions were performed with apheresis platelets from selected donors who were instructed to avoid shrimp consumption, and these transfusions were uneventfully.ConclusionWhen a severe transfusion reaction occurs in a patient with a known food allergy, an IgE‐mediated (food‐related) transfusion reaction should be considered after excluding other causes.
High efficacy of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in Black adults in the United States, including those with pre‐existing HIV resistance and suboptimal adherence
Authors: Andreatta Kristen , D'Antoni Michelle L. , Chang Silvia , Parvangada Aiyappa , Martin Ross , Blair Christiana , Hagins Debbie , Kumar Princy , Hindman Jason T. , Martin Hal , Callebaut Christian 
Published: October 2024

AbstractBRAAVE (NCT03631732), a Phase 3b, multicenter, open‐label US study, demonstrated the efficacy of switching to bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) among Black individuals with suppressed HIV through 48 weeks. Here, 72‐week resistance, adherence, and virologic outcomes are presented. Enrollment criteria permitted nonnucleoside reverse transcriptase inhibitor (NNRTI)–resistance (R), protease inhibitor (PI)–R, and certain nucleos(t)ide reverse transcriptase inhibitor (NRTI)–R (M184V/I allowed; ≥3 thymidine analog mutations [TAMs] excluded); but excluded primary integrase strand transfer inhibitor (INSTI)‐R. Pre‐existing resistance was determined using historical genotypes and retrospective baseline proviral DNA genotyping. Adherence, virologic outcomes, and viral blips were assessed. Of 489 participants receiving B/F/TAF with ≥1 post‐switch HIV‐1 RNA measurement: pre‐existing NRTI‐R (15% of participants), M184V/I (11%), ≥1 TAMs (8%), NNRTI‐R (22%), and PI‐R (13%) were observed; pre‐existing INSTI‐R substitutions (2%) were detected post‐randomization; mean viral blip frequency was 0.9% across all timepoints (unassociated with virologic failure); 24% of participants had <95% adherence (98% of whom had HIV‐1 RNA <50 copies/mL at last visit); none had treatment‐emergent study‐drug resistance. Overall, 99% of participants, including all with baseline NRTI‐R/INSTI‐R, had HIV‐1 RNA <50 copies/mL at the last visit, demonstrating that B/F/TAF maintained virologic suppression through 72 weeks regardless of pre‐existing resistance, viral blips, and suboptimal adherence.
Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis
Authors: Tan Qing , Yang Hongli , He Yong , Shen Xia , Sun Lin , Du Xiaoyan , Lin Gangqiang , Zhou Na , Wang Nishi , Zhou Qian , Liu Dan , Xu Xiaoyan , Zhao Libo , Xie Peng 
Published: October 2024

AbstractBorna disease virus 1 (BoDV‐1) is a neurotropic RNA virus that has been linked to fatal BoDV‐1 encephalitis (BVE) in humans. Ferroptosis represents a newly recognized kind of programmed cell death that marked by iron overload and lipid peroxidation. Various viral infections are closely related to ferroptosis. However, the link between BoDV‐1 infection and ferroptosis, as well as its role in BVE pathogenesis, remains inadequately understood. Herein, we used primary rat cortical neurons, human microglial HMC3 cells, and Sprague‒Dawley rats as models. BoDV‐1 infection induced ferroptosis, as ferroptosis characteristics were detected (iron overload, reactive oxygen species buildup, decreased antioxidant capacity, lipid peroxidation, and mitochondrial damage). Analysis via qRT‐PCR and Western blot demonstrated that BoDV‐1‐induced ferroptosis was mediated through Nrf2/HO‐1/SLC7a11/GPX4 antioxidant pathway suppression. Nrf2 downregulation was due to BoDV‐1 infection promoting Nrf2 ubiquitination and degradation. Following BoDV‐1‐induced ferroptosis, the PTGS2/PGE2 signaling pathway was activated, and various intracellular lipid peroxidation products and damage‐associated molecular patterns were released, contributing to BVE occurrence and progression. More importantly, inhibiting ferroptosis or the ubiquitin‒proteasome system effectively alleviated BVE. Collectively, these findings demonstrate the interaction between BoDV‐1 infection and ferroptosis and reveal BoDV‐1‐induced ferroptosis as an underlying pathogenic mechanism of BVE.
Analytical modeling of STFET biosensor using modulated dielectric for ultrasensitive detection of biomolecules
Authors: Kumar B. Prashanth , Vinod A. , Jena Biswajit , Arivarasi A. , Bahadur Jitendra 
Published: October 2024

AbstractThis paper proposed analytical modeling of a Schottky tunnel field‐effect transistor (STFET)—based biosensor with adjusted gate oxide. This model is developed by resolving the Poisson's equation and calculating the parabolic potential lateral to the channel depth. The special property of the bio‐transistor, which serves as a biosensor, is then included in the analytical modeling of drain current. After the biomolecule interacts with the bio‐transistor, a change in the drain current was employed as a metric to determine the sensitivity. The advanced analytical modeling explored several device restrictions. A device simulation is used to maintain and validate the established and planned characteristic trend. Consequently, the suggested model can be the right solution for the best design and fabrication of a biosensor.
Ascending Vagal Sensory and Central Noradrenergic Pathways Modulate Retrieval of Passive Avoidance Memory in Male Rats
Authors: Edwards Caitlyn M. , Guerrero Inge Estefania , Thompson Danielle , Dolezel Tyla , Rinaman Linda 
Published: October 2024

ABSTRACTVisceral feedback from the body is often subconscious, but plays an important role in guiding motivated behaviors. Vagal sensory neurons relay “gut feelings” to noradrenergic (NA) neurons in the caudal nucleus of the solitary tract (cNTS), which in turn project to the anterior ventrolateral bed nucleus of the stria terminalis (vlBNST) and other hypothalamic‐limbic forebrain regions. Prior work supports a role for these circuits in modulating memory consolidation and extinction, but a potential role in retrieval of conditioned avoidance remains untested. To examine this, adult male rats underwent passive avoidance conditioning. We then lesioned gut‐sensing vagal afferents by injecting cholecystokinin‐conjugated saporin toxin (CSAP) into the vagal nodose ganglia (Experiment 1), or lesioned NA inputs to the vlBNST by injecting saporin toxin conjugated to an antibody against dopamine‐beta hydroxylase (DSAP) into the vlBNST (Experiment 2). When avoidance behavior was later assessed, rats with vagal CSAP lesions or NA DSAP lesions displayed significantly increased conditioned passive avoidance. These new findings support the view that gut vagal afferents and the cNTSNA‐to‐vlBNST circuit play a role in modulating the expression/retrieval of learned passive avoidance. Overall, our data suggest a dynamic modulatory role of vagal sensory feedback to the limbic forebrain in integrating interoceptive signals with contextual cues that elicit conditioned avoidance behavior.
2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation
Authors: Tzeis Stylianos , Gerstenfeld Edward P. , Kalman Jonathan , Saad Eduardo B. , Sepehri Shamloo Alireza , Andrade Jason G. , Barbhaiya Chirag R. , Baykaner Tina , Boveda Serge , Calkins Hugh , Chan Ngai‐Yin , Chen Minglong , Chen Shih‐Ann , Dagres Nikolaos , Damiano Ralph J. , De Potter Tom , Deisenhofer Isabel , Derval Nicolas , Di Biase Luigi , Duytschaever Mattias , Dyrda Katia , Hindricks Gerhard , Hocini Meleze , Kim Young‐Hoon , la Meir Mark , Merino Jose Luis , Michaud Gregory F. , Natale Andrea , Nault Isabelle , Nava Santiago , Nitta Takashi , O’Neill Mark , Pak Hui‐Nam , Piccini Jonathan P. , Pürerfellner Helmut , Reichlin Tobias , Saenz Luis Carlos , Sanders Prashanthan , Schilling Richard , Schmidt Boris , Supple Gregory E. , Thomas Kevin L. , Tondo Claudio , Verma Atul , Wan Elaine Y. 
Published: October 2024

AbstractIn the last three decades, ablation of atrial fibrillation (AF) has become an evidence‐based safe and efficacious treatment for managing the most common cardiac arrhythmia. In 2007, the first joint expert consensus document was issued, guiding healthcare professionals involved in catheter or surgical AF ablation. Mounting research evidence and technological advances have resulted in a rapidly changing landscape in the field of catheter and surgical AF ablation, thus stressing the need for regularly updated versions of this partnership which were issued in 2012 and 2017. Seven years after the last consensus, an updated document was considered necessary to define a contemporary framework for selection and management of patients considered for or undergoing catheter or surgical AF ablation. This consensus is a joint effort from collaborating cardiac electrophysiology societies, namely the European Heart Rhythm Association, the Heart Rhythm Society, the Asia Pacific Heart Rhythm Society, and the Latin American Heart Rhythm Society
Impact of inflammatory bowel diseases on the intimate lives of youths: Creating a brief screening questionnaire
Authors: Mancheron Alexandre , Dumas Agnès , Martinez‐Vinson Christine , Bourmaud Aurélie 
Published: October 2024

AbstractObjectivesThe objectives were to describe the challenges faced by youths with inflammatory bowel disease (IBD) in their intimate lives before the onset of sexual activity and develop a screening tool to detect early difficulties.MethodsWe conducted a cross‐sectional qualitative study via semi‐structured interviews with 15–19‐year‐olds diagnosed with IBD. To be eligible for inclusion, these adolescents had to respond having not yet started their sexual life. This led to a collaborative development of a detection tool with a multidisciplinary team to evaluate adolescents' intimate life stage and to early screen difficulties.ResultsFifteen subjects were recruited. Among them eight were males, 10 were followed for Crohn's disease while five were followed for ulcerative colitis. The median age was 16 years. Nine out of 15 teenagers felt unprepared and reluctant for intimate relationship. Teenagers who have started their romantic journey, expressed satisfaction with their intimate lives, but the possibility of experiencing diarrhea or abdominal pain during intimate moments may be a concern.ConclusionThe study highlights a general reluctance among adolescents with IBD to engage in intimate relationships, and IBD symptoms may be a concern for intimate life. It resulted in the creation of a brief detection tool allowing clinicians to early screen and address intimate life issues, fostering better support for this vulnerable group's challenges.
Combining capillary electrophoresis and chemometric tools for the straightforward determination of imidazolinone herbicides in plant‐based milks
Authors: Aguilera Ángela Y. , Almeida Valber E. , da Silva Oliveira Nadja Maria , de Brito Paulo Ferreira , Mendes Enia Aguiar , Veras Germano , Springer Valeria 
Published: October 2024

AbstractBACKGROUNDHighly polar herbicides, such as imidazolinones, are used for weed control to increase agricultural productivity and crop quality. However, their misapplication can lead to residues in ready‐to‐eat food with a potential health risk for consumers. Hence, the fast determination of these herbicides is necessary for timely action. In this work, an eco‐friendly method based on capillary zone electrophoresis combined with chemometrics was used for the determination of imazapyr and imazamox in vegetable‐based beverages such as soy and quinoa milk.RESULTSThe analytical strategy consisted of only three steps: (i) protein precipitation prior to sample injection (ii) data pre‐processing to reduce the background and make corrections on electrophoretic times shift, and (iii) resolution of fully overlapped capillary electrophoresis (CE) peaks by the well‐known partial least square (PLS) algorithm, which extracts quantitative information attributed to the analytes. The method was successfully applied in the concentration range between 1.00 and 100 μg L−1 with coefficient of determination of the calibration (R2cal) and prediction (R2pred) > 0.90, residual prediction deviation of calibration (RPDcal) and of prediction (RPDpred) > 3, and relative error of prediction (REP) > 11 in the analyzed sample matrices, in the three built methods (quinoa samples, soy samples, and joint quinoa and soy samples).CONCLUSIONThe proposed methodology offers a simple and quick alternative for determining imidazolinones at trace concentrations in vegetable beverages, such as quinoa and soy milk, without complex sample preparation. The results were consistent with those obtained using more complex techniques, confirming the applicability of this method. © 2024 Society of Chemical Industry.
Influencing Factors on Tourists’ Intentions for Sustainable Tourism Destinations: Moderating Effects of Financial Constraints and Moral Reflectiveness
Authors: Laachach Abderrahim , Alhemimah Arej 
Published: October 2024

ABSTRACTThis study investigates the relationships between environmental awareness, travel motivations, tourism knowledge, and intentions to choose sustainable destinations. Using a survey of 495 participants and Partial Least Squares Structural Equation Modeling (PLS‐SEM), we examine how financial constraints and moral reflectiveness moderate these relationships. Our findings indicate a strong positive correlation between environmental values and support for sustainable tourism. Travel motivations, knowledge about sustainable tourism, and a positive environmental attitude all significantly contribute to a tourist's intention to travel sustainably. Interestingly, gender moderates the influence of travel motivations on environmental values, while moral reflection moderates the link between environmental values and the intention to support sustainable tourism. Financial constraints did not have a significant moderating effect. Our study provides valuable insights for stakeholders in the tourism industry, highlighting the importance of aligning strategies with tourist motivations and emphasizing environmental benefits to encourage responsible travel practices.
Transforming Event Experiences: The Role of Application Technology in Shaping Behavioral Intentions and Attachment to Places
Authors: Habachi Salma , Palau‐Saumell Ramon , Matute Jorge 
Published: October 2024

ABSTRACTThis study develops an integrated model that investigates the impact of app technology on event experiences and subsequent consumer behaviors—place attachment, affective commitment, and behavioral intentions. In the context of sports tourism events, data were collected from 219 international participants during the 12th Transpyr race in 2022. Results suggest that perceived usefulness, information value, and perceived enjoyment are drivers of users' app satisfaction, though perceived ease of use did not directly impact app satisfaction. App satisfaction positively impacted event experiences, fostering place attachment, behavioral intention (intention to participate, word‐of‐mouth, electronic word‐of‐mouth), and affective commitment. Affective commitment also influenced behavioral intentions positively, unlike place attachment. This study extends the tourism and consumer behaviors literature. It also presents a new perspective on the TAM model by measuring the users' online experience and its impact on the event experience. Additionally, it provides event organizers with guidelines for building successful experiences.
Consumer Adoption of Mobile Payment Systems: A Lens Into Smartphone‐Enabled Tourism
Authors: Hameed Irfan , Zainab Bibi , Khan Kamran 
Published: October 2024

ABSTRACTThis research examines the factors influencing the success or failure of mobile payment systems (MPSs) in the travel sector. The research makes use of components from innovation resistance theory (IRT), coping theory (CP), and the unified theory of acceptance and use of technology (UTAUT 2). The data were gathered from 503 travelers in Malaysia, and Statistical Package for Social Sciences (SPSS) and SmartPLS were used to analyze the data. Usage, risk, and tradition barriers from IRT significantly influenced tourists' intention to use MPS. Furthermore, all direct hypotheses for CP components were supported, except for the mediating role of satisfaction. Additionally, effort expectancy, hedonic motivation, and habit (UTAUT 2) were identified as critical factors shaping tourists' intention to use MPS. These findings are crucial for tourist operators, banks, and governmental agencies to facilitate smooth and trackable financial transactions in the travel and tourism sector.
Swallowing Kinematics in Male Patients with Total Laryngectomy
Authors: Gölaç Hakan , Aydınlı Fatma E. , Dumbak Aydan B. , İncebay Önal , Enver Necati , Yapar Dilek , Düzlü Mehmet , Bulut Elif G. , Süslü Nilda S. , Yılmaz Metin 
Published: October 2024

ObjectiveThe present study aimed to investigate the symptomatic swallowing complaints in individuals with total laryngectomy (TL) and reveal how swallowing kinematics differs between those with and without symptomatic dysphagia complaints.MethodsA total of 34 subjects with TL were included in the study. Swallowing kinematics of those with symptomatic swallowing complaints (Group 1) were compared to those without (Group 2). Kinematic parameters including pharyngeal transit duration (PTD), maximum pharyngeal constriction ratio (MPCR), upper esophageal sphincter opening ratio (UESOR), upper esophageal sphincter opening duration (UESOD), and bolus clearance ratio (BCR) were investigated from Videofluoroscopic Swallowing Study (VFSS) records via ImageJ software.ResultsSymptomatic swallowing complaints were determined in 47.1% of the subjects (n = 16). Difficulty while swallowing solid foods and pills, diminished pleasure of eating, food getting stuck in the throat, and increased level of stress during swallowing were among the major swallowing complaints in the present cohort. PTD, MPCR, and BCR parameters were significantly higher in subjects with symptomatic swallowing complaints than those without.ConclusionThese preliminary findings indicate that almost half of individuals with TL may have symptomatic swallowing complaints. The underlying pathophysiology of this phenomenon may be the devianced kinematic parameters including PTD, MPCR, and BCR in this population. Therefore, it is recommended to include the kinematic measurements in the dysphagia evaluation protocol in individuals with TL, most notably in those with symptomatic swallowing complaints.Level of Evidence3 Laryngoscope, 135:809–817, 2025