bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complications and compliance in professionally-managed and self-managed contact lenses compared with non-contact lens wearers
Authors: Gantz Liat , Weissman Barry A. , Ifrah Reut 
Published: September 2024

Purpose
To test the impact of professional management of soft contact lens wear on symptoms and ocular complications.

Methods
Subjective symptoms and ocular complications of soft CL users who did not seek professional follow-up care (self-managed, SM), were compared to users who were prescribed CLs and their care professionally managed in optometry practices (PM), and to a control group of non-CL wearers. Habitual visual acuity, subjective dry-eye symptoms, and corneal abnormalities were assessed in all participants. CL wearers filled-out a usage habits questionnaire, and their CL fit was assessed. Outcomes were compared using Kruskal-Wallis and Chi Squared tests.

Results
The SM, PM, and non-CL wearers cohorts included 127 (mean age:24.3±5.1, median:23, range:16–45 years,104 female), 132 (mean age:25.5±6.2, median:23, range:18–43 years,103 female), and 56 (mean age:22.3±3.5, median:21, range:18–39 years,36 female) participants, respectively. Meibomian gland dysfunction grade (p = 0.004, p<0.0001), limbal redness (both p = 0.04), corneal neovascularization (both p = 0.003), and papillary conjunctivitis (p<0.0001,p = 0.005) were significantly worse in SM CL wearers compared with both the non-CL wearers and PM CL wearers, respectively. Conjunctival staining was significantly worse in the SM cohort compared with the PM cohort (p = 0.01). 38.6% of the SM compared with 22.8% of the PM CL wearers, had an inappropriate refractive correction (p = 0.006). SM CL wearers wore CLs significantly more years (mean and median 1 year,p = 0.008), for more daily hours (mean and median of 2 hours,p<0.00001), and tended to nap or sleep with their CLs compared with the PM CL wearers (47 vs. 29,p = 0.02). The cohorts did not differ in their subjective symptoms.

Conclusions
Complications are significantly more prevalent in SM CL wearers compared with PM CL wearers, and SM CL wearers tend to wear CLs with incorrect powers, and are less compliant with napping or sleeping with the CLs compared with PM CL wearers. These findings emphasize the importance of fitting, patient education and follow-ups in CL wearers.
Maggot extract accelerates skin wound healing of diabetic rats via enhancing STAT3 signaling
Authors: Wu Mo-Li , Yang Zhe-Ming , Dong Hai-Chao , Zhang Hong , Zheng Xu , Yuan Bo , Yang Yang , Liu Jia , Li Pei-Nan 
Published: September 2024

Background
Diabetic skin wound is a complex problem due to the disruption of normal repairing program and lack of effective remedy. Lucilia sericata larvae (maggot) is a folk method to treat chronic skin wound, while its therapeutic effects on that caused by diabetic remains unknown.

Objective
This study aims to investigate the therapeutic effects of maggot extract (M.E.) on diabetic skin wound and its molecular mechanism by establishing the skin wound model of diabetic Sprague Dawley (SD) rats.

Methods
Diabetic model was established by injecting intraperitoneally streptozotocin in SD rats under specific pathogen-free (SPF) conditions. The rat fasting blood glucose values were ≧16.7 mmol/L 72 hours after intraperitoneal streptozotocin (60mg/kg body weight) injection. The rats were divided into five groups (n = 10/group): normal group: normal SD rats without any treatment, diabetic blank group: the diabetic rats without any treatment, Vaseline group: the diabetic rats dressed with Vaseline, recombinant human epidermal-growth-factor (rhEGF) group: the diabetic rats dressed with a mixture of Vaseline and 200 μg/g rhEGF, M.E. group: the diabetic rats dressed with a mixture of Vaseline and 150 μg/ml maggot extract. The round open wounds (1.0 cm in diameter) down to the muscle fascia were made on both sides of rat dorsa by removing the skin layer (epidermis and dermis) and were daily photographed for calculating their healing rates. Hematoxylin-eosin (HE) and Masson’s trichrome staining were performed on skin wound sections to analyze re-epithelialization and granulation tissue formation. Immunohistochemical (IHC), immunofluorescent (IF) stainings and Western blotting were conducted to analyze the statuses of STAT3 signaling.

Results
The average wound healing rates on the 14th day were 91.7% in the normal, 79.6% in M.E., 71% in rhEGF, 55.1% in vaseline and 43.3% in the diabetes blank group. Morphological staining showed more active granulation tissue formation, re-epithelialization and neovascularization in M.E.-group than those in the blank and the vaseline-treated groups. Decreased p-STAT3 nuclear tranlocation and down-regulated Bcl-2, CyclinD1 and vascular endothelial growth factor (VEGF) expression were evidenced in the diabetic rats, which could be improved by rhEGF and especially M.E.

Conclusion
Maggot extract would be an alternative and/or adjuvant candidate for the better management of diabetic skin wounds because of its activity in enhancing STAT3 activation.
Beyond the healthcare system: The societal and contextual factors impacting parents’ participation in decision-making for neonates with life-threatening conditions
Authors: Oskouie Fatemeh , Khanjari Sedigheh , Banazadeh Marjan 
Published: September 2024

BackgroundParents of neonates with life-threatening conditions and professionals, bear the burden of making complex decisions. Parents may not be fully involved in decision-making, and there is a paucity of evidence regarding the influence of social context on parents’ participation. We aimed to explore factors that extended beyond the healthcare system and impacted parents’ participation in decision-making for neonates with life-threatening conditions.Materials and methodsThis qualitative research was carried out in 2019 in four level-III Iranian NICUs, (neonatal intensive care units) where twenty-three face-to-face semi-structured interviews were conducted, transcribed, and analyzed using a conventional content analysis technique. Interviews were condensed into meaningful units during the coding phase, resulting in 206 open codes. These codes were then categorized into eleven categories based on commonalities and distinctions. This iterative process continued until 4 main subcategories were established.ResultsThe main categories and sub-categories were “unmodified regulations according to the neonatology advances” (lack of regulations to modify ineffective treatments, lack of a legally documented do not resuscitate order, lack of a defined regional neonatal viability threshold, and lack of maternal guardianship of child medical care), “deficiencies of the health insurance system”(covering the cost of ineffective treatments and lack of insurance covering for palliative care services), “treatment-oriented culture in society” (expecting a miracle for medical science, difficult acceptance of neonatal death and difficult acceptance of home death), and “physician-oriented culture in society”(excessive respect for physicians’ decision-making eligibility and social position of physicians).ConclusionThe findings revealed concepts surrounding parents’ participation in decision-making for life-threatening conditions neonates are influenced by social, legal, cultural, and financial aspects. To bridge the gap between healthcare professionals’ attitudes and cultural and religious beliefs, fatwas, and laws, a collaborative approach is necessary. To address the complex challenges of decision-making for these neonates, involving stakeholders like clinicians, legal experts, Islamic scholars, sociologists, jurists, judges, and medical ethicists is crucial for modifying laws to align with neonatology advancements.
Au plus près du “différend”
Authors: OST François 
Published: September 2024

Ce colloque pose la question radicale de notre temps : la diffraction sociale et culturelle actuelle, la revendication identitaire des minorités, la mise en avant systématique du « droit à la différence » ne discréditent-elles pas définitivement les grandes entreprises de médiation collective que sont le droit et la traduction - autrement dit, l’empire de la norme qui fait lien, et l’emprise du langage qui assure la reconnaissance ?Mon constat est celui de l’isomorphie de ces mises en question ; mon intuition est celle d’une pareille isomorphie des manières dont il convient de les prendre au sérieux et de les traiter (les traiter, c’est-à-dire les assumer, et non les résoudre comme si on pouvait les dissoudre); mon souhait est de tenir le plus longtemps possible les deux bouts de la question : ne rien lâcher quant à la nécessité de la médiation et de la traduction tant du langage que du droit, tout en me tenant au plus près du « différend ». Comment donc faire droit aux revendications du particulier, et en même temps plaider en faveur des ressources médiatrices – mieux innovatrices – du langage et des valeurs à prétention générale ? Comment penser un jeu à somme positive ? Comment imaginer un dispositif social à « propriété émergente » où le tout est plus grand que la somme des parties ?
Schillers Turandot zwischen Maskenspiel und Ideendrama: Betrachtungen zu einer Chinoiserie als eurasische Verschränkung
Authors: Deng Jialai , Ren Weidong 
Published: September 2024

Zusammenfassung
Die literarische Darstellung einer Fremdkultur vollzieht sich als eine transformative Konfiguration. Indem das dargestellte Fremde als Gedankenfigur erscheint, wird die substanzielle Alterität zu einer diskursiven. Dabei steht die Dichtung mit anderen Textgenres in einem reziproken, aber nicht explikativen Verhältnis. Sie eröffnet der diskursiven Alterität neue Dimensionen, indem sie in ihrer Eigendynamik auf das Fremde Bezug nimmt und zugleich über das Eigene reflektiert. Ausgehend von dieser Grundposition kann Friedrich Schillers Turandot. Prinzessin von China bis zu einem gewissen Grad als ein dramaturgischer Versuch interkulturellen Schreibens gelesen werden. Schillers Sublimation der Commedia dell’arte findet in einem dreifachen Kontext statt: dem Geschlechterdiskurs, dem Chinabild seit der Aufklärung sowie der Entwicklung des Turandot-Stoffs in den Prätexten. Schiller bedient sich seiner idealisierten Kenntnisse durch Lektüren von Übersetzungen literarischer und geo-historiographischer Beschreibungen über China als eine landwirtschaftliche Zivilisation, schafft daraus eine chinesische Prinzessin als eurasische Verschränkung: Turandot tritt im orientalischen Kolorit auf, verkündet jedoch einen Kampf wider die konventionelle Frauenrolle für die eigene Autonomie. Es ist nicht nur ihre Schönheit, sondern vor allem die Würde ihrer Freiheitsgesinnung, welche die Liebe bei Kalaf hervorruft, eine Liebe, welche die märchenhafte Repetition von Rätsellösung und Tötung überwindet und die schöne Seele als Inbegriff der Humanität erscheinen lässt.
Refrachor (F) – seventy-year-old tool and a contemporary observation: estimation of equilibrium compositions of 1H- and 2H-tautomers of tetrazole and 1,2,3-triazole and imine–amine composition of acetaldimine–vinylamine tautomerism
Authors: Rachuru Sanjeev , Vandanapu Jagannadham 
Published: September 2024

Abstract
Refrachor with a symbol F a new physical constant proposed for the first time in 1951 by Joshi and Tuli defined by the equation F = –P log(

n
D
20

${n}_{\mathrm{D}}^{20}$

–1) where P is the parachor and

n
D
20

${n}_{\mathrm{D}}^{20}$

is the refractive index, is now used in our present work to calculate the percentage composition of 1H- and 2H-tautomers of tetrazole, 1,2,3-triazole, and imine-enamine tautomerism of acetaldimine in their equilibrium mixtures.
Predictors of Abnormal Renal Ultrasonography in Children With Urinary Tract Infection
Authors: Leahy Catharine , Hanson Keith A. , Desai Janki , Alvarez Alvaro , Rainey Shane C. 
Published: September 2024

BACKGROUND AND OBJECTIVES
The 2011 American Academy of Pediatrics guidelines recommended a renal and bladder ultrasound (RBUS) after the first febrile urinary tract infection (UTI) in infants. Abnormal RBUS findings may be due to inflammation from the acute UTI or from vesicoureteral reflux (VUR), which may require a voiding cystourethrogram (VCUG) to diagnose, increasing health care costs. Our objective was to evaluate the effect of timing of imaging relative to the acute illness on abnormal dilation on RBUS and VCUG findings.

METHODS
Multicenter, retrospective study of patients aged 2 to 24 months presenting with first UTI and RBUS from January 1, 2015, to December 31, 2019. Demographics, isolated pathogen, and timing of RBUS and VCUG relative to urine culture date were recorded and compared.

RESULTS
A total of 227 patients were included. On multivariable logistic regression, increased time in days to RBUS was associated with decreased odds of abnormal dilation (adjusted odds ratio, 0.980; P = .018) in those patients meeting culture criteria for UTI (for each additional day of delay in obtaining RBUS, the adjusted odds of detecting dilation decreased by ∼2%). There was no significant association between timing of imaging and VUR on VCUG. Additionally, 32% of patients underwent RBUS who did not meet UTI culture criteria but had similar rates of abnormal dilation and VUR to those meeting UTI culture criteria.

CONCLUSIONS
Increased time to RBUS led to decreased odds of abnormal dilation, suggesting that delaying RBUS may lead to fewer false-positive results, which may limit unnecessary additional testing and reduce health care costs. Additionally, a significant number of patients who did not meet UTI culture criteria underwent RBUS but had similar results to those meeting criteria, suggesting that the previous colony-forming unit definition for UTI may be suboptimal.
Perceived Effects of COVID-19 on Vaccine Hesitancy and Clinician Discussion: A Qualitative Study
Authors: Gurfinkel Dennis , Tietbohl Caroline , Clark Emma , Saville Alison , Albertin Christina , O’Leary Sean T. , Szilagyi Peter G. , Kempe Allison 
Published: September 2024

BACKGROUND AND OBJECTIVES
Studies note a high prevalence of pediatric coronavirus disease 2019 (COVID-19)-specific vaccine hesitancy in the United States. Our objective was to assess whether clinicians perceive a spillover effect of COVID-19 vaccine hesitancy onto other vaccines, and the impact of this spillover on their general recommendation behavior.

METHODS
We conducted semistructured interviews with pediatricians in California and Colorado pediatric practices (January–March 2023). We transcribed, coded, and analyzed interviews using content analysis.

RESULTS
We interviewed 21 pediatricians (10 in California, 11 in Colorado). Clinicians observed some spillover effect of vaccine-favorable changes among some parents and greater hesitancy among others regarding the risks and benefits of childhood vaccination in general. This spillover was informed by 2 divergent patterns of parental trust in health systems and individual clinicians caused by the COVID-19 pandemic. Factors driving perceived changes included media coverage, greater knowledge about vaccination, and misinformation. Some clinicians felt that their approach to vaccine recommendations became more patient-centered, whereas others reported declining engagement in persuading hesitant parents about vaccination.

CONCLUSIONS
Clinicians described a hardening of parental views toward vaccines in both directions, which impacted their recommendation behavior. There is a need for vaccine hesitancy monitoring and better training and support for clinicians facing vaccine hesitant parents.
A New Find of Anorthoclase Crystals-lined Vug in a Deep-sea Basalt, Central Indian Ocean Basin
Authors: Iyer Sridhar D. , Amonkar Ankeeta , Kalangutkar Niyati G. , Das Pranab 
Published: September 2024

ABSTRACTWe detail a new and first find of a vug in a deep-sea basalt that is lined with well-formed anorthoclase crystals. The specimen was dredged from the seafloor (water depth 4,440 m) near a seamount in the Central Indian Ocean Basin. The basalt has a thin veneer of glass covered with ferromanganese (FeMn) oxides while the interior is quite fresh. The geochemical analysis of the basalt depicts different degrees of alteration that vary from the outermost layer with FeMn oxides to the interior of the specimen. In general, the TiO2 (&lt;1.5 wt%) and MgO (~5 wt%) contents are low while CaO, Na2O, K2O and P2O5 contents change within the specimen. The FeMn oxides have Fe2O3 (21 wt%) and MnO (8–27 wt%) and appear as botryoids and occur near and/or over the anorthoclase crystals. The trace and rare earth elements do not show significant variations from the outer to the interior of the specimen. Microscopy (binocular and scanning electron) and energy dispersive spectrometry of the vug revealed a dominance of drusy anorthoclase crystals. The formation of the anorthoclase crystals is ascribed to precipitation from hydrothermal solutions that seeped into the basalt through cracks. This is attested by the co-existing crystals of phillipsite and feldspar and FeMn oxides.
Renal denervation benefits in chronic kidney disease: An updated review
Authors: Habas Elmukhtar M. , Alarbi Khaled , Habas Ala , Baghi Mohamed , Habas Eshrak , Rayani Amnna , Said Abdusslam , Farfar Kalifa , Errayes AlMehdi , Alfitori Gamal , Habas Aml , Elzouki Abdel Naser 
Published: September 2024

Hypertension (HTN) may not be properly controlled despite the ideal blood pressure (BP)-lowering drugs and good patient compliance. These scenarios emphasize the need for innovative approaches to treat HTN cases that are difficult to manage pharmaceutically. Numerous recent studies have documented the effectiveness of renal denervation (RDN) therapy in reducing sympathetic nerve system (SNS) overactivity. Although this therapy is invasive and expensive, its appropriate use in specific cases is still being refined.SNS overactivity is documented in HTN, chronic kidney disease (CKD), and end-stage renal disease patients. Over the past decade, RDN therapy has been used in different countries to treat HTN, with a positive response in most cases. However, some hospitals have no resources or interventionists to perform these procedures. Nonetheless, there is an increased number of physicians expressing interest in using RDN in sustained HTN therapy and prevention of CKD progression. There are no consensus guidelines worldwide; however, some societies have developed guidelines for using RDN based on updated information covering the BP-lowering mechanism, efficacy, patient selection, post- and preprocedural assessment, and procedural safety. In this review, we aimed to evaluate the effectiveness of the RDN procedure for treating HTN and prevention of CKD development and progression.
Diagnostic approach to pleural effusion based on pathogenesis and radiological findings: A narrative review
Authors: Habas Elmukhtar M. , Habas Ala , Said Abdusslam , Rayani Amnna , Farfar Kalifa , Habas Eshrak , Alfitori Gamal , Errayes Almehdi , Habas Aml , Elzouki Abdel Naser 
Published: September 2024

Pleural effusion (PE) is a common feature of various diseases. The most common causes of PEs are infection, pulmonary embolism, and heart failure. Other diseases include rheumatological diseases, ovarian hyperstimulation syndrome, liver cirrhosis, hypoalbuminemia, and nephrotic syndrome.The principle of PE pathogenesis is either increased fluid production or decreased fluid removal from the pleural cavity, mainly by the parietal pleural layer. According to the underlying cause, the pathogenesis could be due to increased permeability, decreased oncotic pressure or increased hydrostatic pressure of parietal pleural capillaries, increased fluid oncotic pressure, tumor invasion to the pleura, increased lymphatic vessel hydrostatic pressure, lung inflammation, and increased lung interstitial fluid content.Exploring the underlying cause and pathogenic mechanism is the best approach and is immensely helpful in planning the treatment of PE. Treating the underlying cause is the primary approach in treating PEs; thoracocentesis, pleurodesis, pleurectomy, and other possible modalities are applied when indicated, mainly to relieve symptoms. Hence, this review article will discuss the conceivable pathophysiological mechanisms of PEs, common etiologies, radiological diagnostic modalities, and the available therapeutic options.
Shedding Light on tRNA-Derived Fragment Repertoire in Facs Blood Cells
Authors: Artamonov Alexander Andreevich , Kondratov Kirill , Bystritsky Egor , Nikitin Yuriy , Velmiskina Anastasiya , Mosenko Sergei , Polkovnikova Irina , Asinovskaya Anna , Apalko Svetlana , Sushentseva Natalya , Ivanov Andrej Mixajlovich , Shcherbak Sergey 
Published: September 2024

tRNA-derived fragments function as markers additionally to playing the role key of signalling molecules in a number of disorders. It is known that the repertoire of these molecules differs greatly in different cell types and varies depending on the physiological condition. The aim of our research was to compare the pattern of tRF expression in the main blood cell types and to determine how the composition of these molecules changes during COVID-19-induced cytokine storm. Erythrocytes, monocytes, lymphocytes, neutrophils, basophils, and eosinophils from control donors and patients with severe COVID-19 were obtained by fluorescence sorting. We extracted RNA from FACS sorted cells and performed NGS of short RNAs. The composition of tRNA-derived fragments was analysed applying a semi-custom bioinformatic pipeline. In this study, we assessed the length and type distribution of TRFs and reported the 150 most prevalent TRF sequences across all cell types. Additionally we demonstrate a significant (p&lt;0.05, fold change&gt;16) change in the pattern of tRFs in erythrocytes (21 downregulated, 12 upregulated), monocytes (53 downregulated, 38 upregulated) and lymphocytes (49 upregulated) in patients with severe COVID-19. Thus, different blood cell types exhibit a significant variety of TRFs and react to cytokine storm by dramatically changing their differential expression patterns. We suppose that the observed phenomenon occurs due to the regulation of nucleotide modifications and alterations in activity of various Rnases.
Synthesis Process and Nutritional Evaluation of Plantain as a Supplementary Food for Toddlers in Sierra Leone: A Study Utilizing Biuret’s, Benedict’s, and Iodine Solution Test
Authors: Koroma Lahai , Senesie James Kuiva , Baion Florence Wuyah , Lukulay Baindu Miata , Kallon Massah Badiwuloi 
Published: September 2024

Research on developing plantain fruit into juice, jam, ice cream, and fritters as a food supplement for toddlers was conducted in Sierra Leone. The work was done at the Mosoudo section of Daru village, Jawie Chiefdom, in Kailahun District. Four bunches of plantains were harvested from Jawei Chiefdom and stored in Mosoudo. Two bundles of the raw plantain were peeled, dried, and ground into powder, while the other two left to ripen at room temperature for nine days. Test were conducted using Iodine solution, Benedict solution, and Biuret test to check the presence of starch, glucose, and protein, respectively, in both the powdered and ripe plantain. The ripe plantains were then made into juice, jam, ice cream, and fritters. Fifty mothers/caregivers, along with their children, were randomly selected to evaluate the color, taste, smell, and texture of the four plantain products. The sensory evaluation results showed high acceptance levels: color (53.5%), taste (59.0%), smell (61%) and texture (59.9%). The results suggest that the project could successfully provide nutritious and appealing food supplements for toddlers in Sierra Leone. It was recommended that the government and NGOs promote the cultivation of plantains instead of importing food supplements for children in Sierra Leone.