bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retinal Organoids from Induced Pluripotent Stem Cells of Patients with Inherited Retinal Diseases: A Systematic Review
Authors: Lee Yoo Jin , Jo Dong Hyun 
Published: October 2024

Abstract

Background
Currently, most inherited retinal diseases lack curative interventions, and available treatment modalities are constrained to symptomatic approaches. Retinal organoid technology has emerged as a method for treating inherited retinal diseases, with growing academic interest in recent years. The purpose of this review was to systematically organize the current protocols for generating retinal organoids using induced pluripotent stem cells from patients with inherited retinal disease and to investigate the application of retinal organoids in inherited retinal disease research.

Methods
Data were collected from the PubMed, Scopus, and Web of Science databases using a keyword search. The main search term used was “retinal organoid,” accompanied by secondary keywords such as “optic cup,” “three-dimensional,” and “self-organizing.” The final search was conducted on October 2, 2024.

Results
Of the 2,129 studies retrieved, 130 were included in the qualitative synthesis. The protocols for the generation of retinal organoids in inherited retinal disease research use five major approaches, categorized into 3D and a combination of 2D/3D approaches, implemented with modifications. Disease phenotypes have been successfully reproduced via the generation of retinal organoids from the induced pluripotent stem cells of individuals with inherited retinal diseases, facilitating the progression of research into novel therapeutic developments. Cells have been obtained from retinal organoids for cell therapy, and progress toward their potential integration into clinical practice is underway. Considering their potential applications, retinal organoid technology has shown promise across various domains.

Conclusion
In this systematic review, we organized protocols for generating retinal organoids using induced pluripotent stem cells from patients with inherited retinal diseases. Retinal organoid technology has various applications including disease modeling, screening for novel therapies, and cell replacement therapy. Further advancements would make this technology a clinically significant tool for patients with inherited retinal diseases.

Graphical Abstract
Chaos in Bitcoin Cryptocurrency Metrics: Analysis and Forecasts
Authors: Gezer Ali 
Published: October 2024

AbstractCryptocurrencies, particularly Bitcoin have attracted a lot of attention in the last decades of humanity. Analyzing cryptocurrencies algorithmic differences, chaotic behavior and self-similarity in cryptocurrency metrics might give significant insights for identifying risks and opportunities. Determining the degree of chaos in crypto metrics is critical for understanding complexity, improving prediction capabilities, and supporting decision-making. This study focuses on the analysis of chaos and self-similarity in Bitcoin dynamics for predictability perspective. Return, rate of return and volume quantities in different scales are analyzed with using rescaled range method to reveal the degree of self-similarity. Hurst parameter extracts a comprehensive summary providing information on how current values depend on previous ones to reveal any persistence in Bitcoin metrics. Daily rate of return and return give Hurst degree around 0.64 while they are in between 0.52–0.55 for minutely and hourly based prices. However, an increasing persistence is observed with the increasing time window. Although the largest Lyapunov exponents stay in the positive region for prices and returns of Bitcoin, they are approximately zero for inspected statistics. Periodic characteristics of Bitcoin are also investigated to reveal any dependencies on halving mechanism of Bitcoin. Detailed self-similarity analysis on specific periods shows that bull and bear market seasons don’t make any significant effect on the degree of Hurst parameter. Due to nonlinear and unpredictable characteristics of Bitcoin metrics, distribution fittings are applied to characterize BTC return and rate of return. While Wakeby distribution gives best fitting for daily return, Cauchy distribution gives best for hourly returns.
Improving the Science of Adolescent Social Media and Mental Health: Challenges and Opportunities of Smartphone-Based Mobile Sensing and Digital Phenotyping
Authors: Hamilton Jessica L. , Dreier Melissa J. , Caproni Bianca , Fedor Jennifer , Durica Krina C. , Low Carissa A. 
Published: October 2024

AbstractThe impact of social media (SM) use (‘screentime’) on adolescent mental health has been the focus of increasing concern, despite mixed findings from empirical research. Current methodological approaches rely on self-reported SM use, which has limited accuracy and obscure the dynamic interplay of SM use and mental health. Smartphone-based mobile sensing offers new opportunities to gain insights into adolescents’ SM use patterns and behaviors, particularly at an idiographic level. Considerations and challenges of smartphone sensing methods for capturing adolescents’ SM use patterns and behaviors in clinical psychological science are discussed in the context of a pilot study using smartphone-based sensing with adolescents. The pilot study included 19 adolescents (Mean age = 15.84; 68% boys; 79% White) who installed a passive monitoring application (AWARE) on their phones for 31 (SD = 5.6) days. Descriptive data of sensing acceptability and feasibility are presented based on participant ratings and data yield ratio of usable data (74.18%). Sensing yielded 10,038 hourly observations collected from the ‘application foreground’ sensor across all participants from social media apps, and a total of 645 applications used. Categorization of SM apps were coded (kappa >.90) into ‘social networking’ (N = 20 apps) and ‘broader SM’ (N = 41) and compared to both Play Store-defined SM apps (N = 26) and popular SM apps based on Common Sense Media Survey (N = 9). Descriptive data on extracted behavioral features (duration, checking) from SM use categories (binned hourly and daily) are presented. Challenges, opportunities, and future directions of sensing methods for SM use are discussed to inform our understanding of its impacts on mental health and to improve the rigor of SM research in clinical psychological science.
Real-world experience of emicizumab prophylaxis in Korean children with severe hemophilia A without inhibitors
Authors: Kim Sung Eun , Kim Ji Yoon , Park Jeong A , Lyu Chuhl Joo , Hahn Seung Min , Han Jung Woo , Park Young Shil 
Published: October 2024

Abstract
Purpose
Hemophilia A is a genetic disorder characterized by a lack of factor VIII (FVIII). Emicizumab, a recombinant humanized bispecific monoclonal antibody, mimics the function of FVIII. In this article, we present data on an initial real-world evaluation of emicizumab use in Korean children with severe hemophilia A without inhibitors.

Methods
This study was conducted from June 2020 to March 2024 at 4 centers in Korea. The participants were pediatric patients with severe hemophilia A without inhibitors who had received emicizumab treatment for over 6 months. The mean and median annualized bleeding rates (ABRs) and mean and median annual joint bleeding rates (AJBRs) were compared.

Results
Each of the 21 patients in the study received an emicizumab loading regimen of 3 mg/kg weekly for 4 weeks, followed by a modified maintenance regimen of which 2 patients (9.5%) received a 1.5 mg/kg weekly dose, 3 patients (14.3%) received a 6 mg/kg dose every 4 weeks, and the remaining 16 patients (76.2%) received a 3 mg/kg dose every 2 weeks. Before emicizumab prophylaxis initiation, the mean and median ABRs for all patients were 7.04 (SD ± 5.83) and 6.52 (range 0–21.74), respectively. After receiving emicizumab treatment, the mean and mediam ABRs decreased to 0.41 and zero, respectively. Additionally, 85.7% of the patients achieved no bleeding events within 6 months of starting the treatment.

Conclusion
These first real-world data in Korea indicate that emicizumab is effective and safe for pediatric patients with severe hemophilia A without inhibitors.
Negotiating Common Goals Among Diverse Stakeholders: An Ethnography of the Czech Environmental Education’s Organisational Field
Authors: Cuker Ivan , Hájek Martin 
Published: October 2024

AbstractThe development of environmental education (EE) goals has rarely been problematised. To shed light on this process, we focused on EE in the Czech Republic. Non-governmental organisations (NGOs) play a key role there, facilitating the process in coordination with government institutions, schools and for-profit companies. Drawing on three theoretical perspectives that explain the formation of organisational goals (consensus building, community of discourse and practice and governmentality), we examined how different stakeholders contribute to the definition of common goals for EE. Through ethnographic research in an NGO and at EE events, complemented by interviews with lecturers and leaders, our research revealed that despite the high diversity of stakeholder positions and interests, the organisational field of EE is highly inclusive and shows few internal conflicts. Using chosen theoretical perspectives, we explain how vaguely defined common goals and weak manifestations of conflict contribute to the sharing of knowledge, practices and ethical responsibilities in the EE field.
Reclaiming what is ours: Elite continuity and revanchism
Authors: Snegovaya Maria , Lanoszka Alexander 
Published: October 2024

Abstract
What explains the revanchism of (post-)imperial states? This question has renewed salience amid Russia’s expanded war against Ukraine in 2022. In this article, we conceptualise revanchism as a foreign policy preference that involves reclaiming territory once controlled. We also advance a new explanation for revanchism that emphasises elite continuity in those states that experience territorial loss. Elite continuity matters because the ruling political class in (post-)imperial states, which was socialised under the old regime, preserves certain beliefs about world politics and the perceived legitimacy of their territorial claims. We show that elite continuity between the Soviet and post-Soviet political leadership in Moscow helps explain Russia’s revanchism better than those alternative explanations that we derive from the International Relations literature. To substantiate our argument, we compile a novel dataset to operationalise elite continuity across regimes and use discursive evidence and other indicators of elite attitudes towards the desirability of reclaiming lost territory. We also discuss the applicability of our theory to other cases.
Financial literacy in the DNB Household Survey: insights from innovative data collection
Authors: van Rooij Maarten , Alessie Rob , Lusardi Annamaria 
Published: October 2024

AbstractThis paper surveys what we have learned on financial literacy and its relation to financial behavior from data collected in the Dutch Central Bank (DNB) Household Survey, a project done in collaboration with academics. A pioneering survey fielded in 2005 included an extensive set of financial literacy questions and questions that can serve as instruments for financial literacy in regression analyses to assess the causal effect of financial literacy on behavior. We describe how this survey spurred a series of research papers demonstrating the crucial role of financial literacy in stock market participation, retirement planning, and wealth accumulation. This inspired various follow-up studies and experiments based on new data collections in the DNB Household Survey. Researchers worldwide have used these data for innovative studies, and other surveys have included similar questions. This case study exemplifies the essential role of data in empirical research, showing how innovative data collections can inspire new research initiatives and significantly contribute to our understanding of household financial decision-making.
Peer counseling for perinatal depression in low- and middle-income countries: A scoping review
Authors: Cuncannon Alexander , Seitz Kailyn , Brar Aneel Singh , Dosani Aliyah 
Published: October 2024

Abstract
Perinatal depression is associated with adverse maternal, newborn and child health outcomes. Treatment gaps and sociocultural factors contribute to its disproportionate burden in low- and middle-income countries (LMICs). Task-sharing approaches, such as peer counseling, have been developed to improve access to mental health services. We conducted a scoping review to map the current literature on peer counseling for perinatal women experiencing depression in LMICs. We searched CINAHL, MEDLINE, APA PsycINFO, Global Health and EMBASE for literature with no date limits. We included 73 records in our analysis, with most being systematic reviews and meta-analyses, randomized controlled trials and qualitative studies. Most studies were conducted in India and Pakistan and published from 2020 onward. The Thinking Healthy Program (THP) and its Peer-Delivered (THPP) adaptation were the most common interventions. Studies suggested effectiveness, feasibility, acceptability and transferability of peer counseling, particularly within the THPP, for perinatal depression. Studies indicated that local women, as peers and lay counselors, are preferred and effective implementation agents. Gaps in the evidence include those relating to understanding perinatal depression (e.g., contextual understandings of the etiology, comorbidity and heterogeneity and social conditions of psychosocial distress including long-term impacts on relationships and children’s development) and understanding and improving implementation. Further research on the adaptation, scaling up and integration of peer-delivered approaches with other approaches to improve impact are needed. There are also gaps in understanding the perspectives and experiences of peer counselors. Evidence gaps may stem from an emphasis on conventional public health approaches and measures derived from Western psychiatry, such as randomized controlled trials. There is relatively little research or implementation that prioritizes peer counselors in terms of understanding their perspectives and experiences (e.g., of professionalization), despite them being central to peer-delivered models. Task sharing has the potential to both empower peer counselors through mental health benefits and professional opportunities but also render peer counselors susceptible to vicarious exposure to traumatic stories and difficult situations amid limitations in available support. Better understanding counselors’ and perinatal women’s experiences can help decolonize the evidence base and improve implementation.
Acceptability and feasibility of a brief intervention to enhance resilience among young people and their families in India and Kenya
Authors: Bhui Kamaldeep , Basu Debasish , Nagpal Sugandha , Mutiso Victoria , Pillai Renjith , Hadfield Kristin , Lauwrens Zelna , Ndetei David 
Published: October 2024

Abstract
Enhancing resilience is one way to prevent future mental illnesses and encourage recovery in the face of adversity. To develop and test the acceptability and feasibility (A&F) of a combined family and individual resilience intervention in two rural/semi-rural low-income settings in India and Kenya. We developed a five-session intervention including Life Skills Education (LSE) and a model of family resiliency. Among adolescents aged 14–16 years and their families in India and Kenya, we collected socio-demographics and audio records of delivery and undertook a process evaluation. Due to COVID-19, we developed a hybrid intervention. The facilitators and participants preferred the in-person model. India: Of 17 families, 10 fully completed the intervention. They identified three critical components: 1) story-telling, 2) cooperation and working together and 3) expressing feelings. Kenya: All 15 families completed the intervention. Critical elements were 1) seeing social value in learning to make good decisions, 2) promoting an optimistic view of life, 3) hearing stories that resonated with their situation and 4) enhancing family performance through knowledge-building. We mapped the active ingredients, showing fidelity and acceptability. The intervention showed promising A&F parameters. Flexibility and local adaptation were important for delivery.
Against the clock to address plastic pollution: Critical challenges to elaborate a comprehensive and ambitious Plastic Treaty
Authors: Gonçalves Leandra R. , Webster D. G. , Grilli Natalia M. , Elliff Carla I. , Scrich Vitoria M. , Lopes Giovanna S. R. , Turra Alexander 
Published: October 2024

Abstract
To address the global challenge of plastic waste, 175 UN Member States are negotiating a legally binding instrument, the Plastic Treaty, aimed at ending plastic pollution. This ambitious framework, targeting both terrestrial and marine sources, is being developed through Intergovernmental Negotiating Committee meetings scheduled to conclude by 2025. Amidst uncertainties and power dynamics influencing state positions, this research identifies 10 critical, yet unresolved, points within the treaty negotiations (i.e., the scope of the treaty, equity and differentiation, involvement of non-state actors, integration with existing agreements, standards and specifications, trade implications, monitoring and reporting, responsibility and historical contributions, binding vs. non-binding commitments, and financing and technology transfer). The findings suggest potential compromises in the treaty’s environmental provisions, influenced by domestic interests and international power disparities. As negotiations progress, the imperative for cooperation and decisive action against plastic pollution becomes increasingly pressing, challenging member states to prioritize global environmental integrity over national interests.
WELL-POSEDNESS RESULTS FOR GENERAL REACTION–DIFFUSION TRANSPORT OF OXYGEN IN ENCAPSULATED CELLS
Authors: NAKAMURA YUMA , PUTRI KHARISMA SURYA , STERK ALEF EDOU , DE JONG THOMAS GEERT 
Published: October 2024

AbstractWe provide well-posedness results for nonlinear parabolic partial differential equations (PDEs) given by reaction–diffusion equations describing the concentration of oxygen in encapsulated cells. The cells are described in terms of a core and a shell, which introduces a discontinuous diffusion coefficient as the material properties of the core and shell differ. In addition, the cells are subject to general nonlinear consumption of oxygen. As no monotonicity condition is imposed on the consumption, monotone operator theory cannot be used. Moreover, the discontinuity in the diffusion coefficient bars us from applying classical results on strong solutions. However, by directly applying a Galerkin method, we obtain uniqueness and existence of the strong form solution. These results provide the basis to study the dynamics of cells in critical states.
Increased physiologic dead space fraction is associated with mortality after comprehensive stage 2 operation
Authors: Hardisky Dariya , Satija Divyaam , Yates Andrew R. , Clark Tamara , Alexander Robin , Galantowicz Mark , Carrillo Sergio A. 
Published: October 2024

AbstractObjective:Our objective was to assess the predictive value of physiologic dead space fraction for mortality in patients undergoing the comprehensive stage 2 operation.Methods:This was a single-centre retrospective observational study conducted at a quaternary free-standing children’s hospital specialising in hybrid palliation of single ventricle cardiac disease. 180 patients underwent the comprehensive stage 2 operation. 76 patients (42%) underwent early extubation, 59 (33%) standard extubation, and 45 (25%) delayed extubation. We measured time to extubation, post-operative outcomes, length of stay and utilised Fine gray models, Youden’s J statistic, cumulative incidence function, and logistic regression to analyse outcomes.Results:Delayed extubation group suffered significantly higher rates of mortality (31.1% vs. 6.8%), cardiac arrest (40.0% vs. 10.2%), stroke (37.8% vs. 11.9%), and need for catheter (28.9% vs. 5.1%) and surgical intervention (24.4% vs. 8.5%) (P < 0.001). Physiologic dead space fraction was significantly higher in the delayed extubation group and in non-survivors with a value of 0.3, which was found to be the discriminatory point by Youden’s J statistic. For a 0.1 unit increase in physiologic dead space fraction on post-operative day 1, the odds of a patient expiring increase by a factor of 2.26 (95% CI 1.41–3.97, p < 0.001) and by a factor of 3.79 (95% CI 1.65–11.7, p 0.01) on post-operative day 3.Conclusions:Delayed extubation impacts morbidity and mortality in patients undergoing the comprehensive stage 2 operation. Increased physiologic dead space fraction in the first 60 hours after arrival to the ICU is associated with higher mortality.
Improving skin-tone inclusivity in patient information leaflets for radiotherapy skin reactions: a literature review
Authors: Knight S. , Macwan S. 
Published: October 2024

Abstract

Introduction:
Radiotherapy is a common treatment modality for cancer patients. Unfortunately, the treatment can result in skin reactions that may affect their quality of life and clinical outcomes. PILs can provide guidance on managing early symptoms and reduce unscheduled treatment breaks. Evaluating PILs is not frequently evidence-based, and research into evaluating PILs’ inclusiveness for radiotherapy skin reactions does not exist. This study aims to contribute to the knowledge base to better serve the whole radiotherapy population.

Methods:
A constructivist methodology was developed to evaluate skin-tone inclusivity in the author’s local PILs, and a literature review was conducted to assess the knowledge base and facilitate providing recommendations for improvement.

Results:
Publication, diagnostic, language and educational bias were identified in the literature. The content analysis found the author’s departmental PILs were not inclusive of medium and dark-skinned patients.

Conclusions:
Further research into radiotherapy PILs inclusivity is warranted. The creation or amendments to existing radiotherapy skin reaction diagnostic tools are needed to cater for the whole population. Diverse educational resources are needed to contribute to the reduction of health inequalities faced by radiotherapy patients.
Long-Term Relationship over Litigation: Mediation in WTO Dispute Settlement Proceedings
Authors: Lee Jaemin 
Published: October 2024

AbstractThe Dispute Settlement Mechanism (DSM), once regarded as the jewel in the crown of the World Trade Organization (WTO), has been facing a variety of serious criticisms for its inherent limitations and problems while its appellate review function has been paralyzed. Discussions on the reform of the WTO DSM have been under way for several years now. Many key items are on the reform agenda, one of which is to introduce Alternative Dispute Resolution (ADR) proceedings to the WTO DSM. Among several options of ADR, ‘mediation’ can offer an important set of tools for the WTO and its Members to resolve disputes in a more efficient and prompt manner. If properly structured, mediation can complement the existing binding proceedings of panels and the Appellate Body. At the same time, introduction of mediation to the WTO DSM may also cause additional legal and practical problems. It may cause further delays, confidentiality traps, due process myriads, and enforcement loopholes. It is vital to introduce mediation provisions to address those critical problems. Systematized and structuralized mediation in the WTO DSM will be able to offer a viable alternative path to resolve certain complex and sensitive disputes.