bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stress fractures in older athletes: a case report and literature review
Authors: Barros André , Karmali Samir , Rosa Bárbara , Gonçalves Ricardo 
Published: April 2017

Key Clinical MessageThe incidence of stress injuries in older athletes is increasing, associated with a more active older population. The same principles apply for its prevention and treatment, but older athletes usually present a more adverse outcome. It is mandatory to raise awareness to this common, but frequently neglected pathology.
A presentation of postcardiac injury syndrome after successful chronic total occlusion percutaneous coronary intervention using dissection re‐entry techniques
Authors: Elbaz‐Greener Gabby , Wijeysundera Harindra C. 
Published: April 2017

Key Clinical MessageRetrograde dissection re‐entry can cause pericardial trauma of sufficient degree to lead to the development of an auto‐immune postpericardial injury syndrome. Clinical suspicion for this condition should be high in the event of fever, symptoms, pericardial/pleural effusion, and pleuritic chest pain following chronic total occlusion (CTO) Post cardiac injury syndromes (PCI).
Error Analysis of Improved Current‐Bridge Method for Accurate Low‐Impedance Measurement
Authors: KON SEITARO , YAMADA TATSUJI 
Published: April 2017

SUMMARYThe improved current‐bridge method and its mathematical mode are proposed for accurate low‐impedance measurement. To realize the accurate measurements of shunt resistors smaller than 1 mΩ, the expansion of current ratio of a current transformer and a current comparator, the use of low‐value resistance for reference impedance, and the development of a buffer amplifier which have flat load characteristics are required. The improved current bridge‐method has the possibility for accurate measurement of shunt resistors up to 10 μΩ.
Analysis of Physiological Effect of Reading Books by Paper and Electronic Medium
Authors: BANDO SHIZUKA , ASANO HIROTOSHI , NOZAWA AKIO 
Published: April 2017

SUMMARYDigital books have become popular as electronic media has become more common. An evaluation that includes not only a subjective assessment of readability or usability, but also an objective assessment of psychometric health impact is needed. The goal of this study is an objective assessment of the physiological and psychological effects of reading books using electronic or paper media. This paper focuses on hemodynamic parameters. The measurement items include VAS and POMS as a psychological index and hemodynamic parameters as a physiological index. As a result, low levels of vigor and limited readability were recognized as significant (p < 0.05) when reading a book using electronic media as compared to paper media. The cardiovascular system was actively engaged in coping because of sympathetic hyperactivity in the hemodynamic reaction. By contrast, using electronic media was not seen to involve stress coping. We also found that the parasympathetic nervous system activity was enhanced by the illegibility of sentences and fatigue due to using electronic media. Based on all of these results, we identified a difference in how people react physiologically when reading a book using electronic and paper media.
Study on Temperature Measurement Using MRI during Acupuncture and Moxibustion
Authors: NAKAMURA SUGURU , NAKAMURA MASAMICHI , MAEDA EIICHI , NIKAWA YOSHIO 
Published: April 2017

SUMMARYIn the field of traditional oriental medicine, two types of treatment style, which are acupuncture treatment and moxibustion treatment, have been performed. These treatments are used and effected by doctors or acupuncturists in their clinic or hospital and widely spread. Although such a general treatment, mechanism of heat transfer modality and temperature distribution in the treatment of moxibustion is not deeply discussed. Also, temperature distribution of deep human tissue during acupuncture treatment is not discussed. It is derived from the difficulty of noninvasive measurement of internal human body with small change of electromagnetic wave signals noninvasively. In this study, a temperature distribution for acupuncture and moxibustion treatment is measured and analyzed using thermography and MRI by measuring the phase of longitudinal relaxation time of protons. The experimental results of measured temperature distribution under the human legs have been demonstrated. The result of temperature analysis in the human body is also reported.
Comparison of Switching Loss of Single‐Phase Step‐Up/Step‐Down Bidirectional Converter with Voltage‐Fed/Current‐Fed Hybrid‐Type Operation
Authors: HOSOKAWA SHOJI , MOTEGI SHIN‐ICHI , NISHIDA YASUYUKI 
Published: April 2017

SUMMARYElectric energy storage systems are very important as one of the solutions to global warming. Step‐up/step‐down characteristics are required for electric energy storage systems. In addition, such systems must have high efficiency, low cost, and small scale. Therefore, the authors proposed a single‐phase step‐up/step‐down bidirectional converter with voltage‐fed and current‐fed hybrid‐type operation. The proposed converter consists of a two‐quadrant dc–dc converter and a single‐phase voltage‐fed converter. The circuit has several advantages such as low switching loss, use of very small capacitance, and so on. In this paper, the authors compare a comparison of the switching losses with a simple analysis.
Toxicity of sediment-associated substituted phenylamine antioxidants on the early life stages of Pimephales promelas and a characterization of effects on freshwater organisms
Authors: Prosser Ryan S. , Parrott Joanne L. , Galicia Melissa , Shires Kallie , Sullivan Cheryl , Toito John , Bartlett Adrienne J. , Milani Danielle , Gillis Patty L. , Balakrishnan Vimal K. 
Published: April 2017

Abstract

Substituted phenylamine antioxidants (SPAs) are high production volume chemicals that are incorporated into a variety of commercial products (e.g., polymers, dyes, lubricants). There are few data on chronic toxicity of SPAs to fish and no data on the toxicity of SPAs to the early life stages of fish. The physicochemical properties of SPAs would suggest that if they were to enter an aquatic ecosystem they would partition into sediment. Therefore, the present study focused on investigating the chronic effect of sediment-associated SPAs to the early life stages of the fathead minnow (Pimephales promelas). Eggs and larvae were exposed to sediment spiked with diphenylamine (DPA), N-phenyl-1-napthylamine (PNA), N-(1,3-dimethylbutyl)-N′-phenyl-1,4-phenylenediamine (DPPDA), or 4,4′-methylene-bis[N-sec-butylaniline] (MBA). The most sensitive endpoint for DPA, PNA, and DPPDA was total survival with 21-d median lethal concentrations (LC50s) based on concentration in overlying water of 1920, 74, and 35 μg/L, respectively. The most sensitive endpoint for MBA was growth with a 21-d median effective concentration (EC50) of 71 μg/L. The same endpoints were the most sensitive in terms of concentrations of DPA, PNA, DPPDA, and MBA in sediment (101, 54, 111, and 76 μg/g dry wt, respectively). Species sensitivity distributions (SSDs) were constructed for each SPA based on acute and chronic toxicity data generated in the present study and found in the literature. Overall, P. promelas was in the midrange of chronic sensitivity, with the most sensitive species being Tubifex tubifex. The SSDs indicate that DPA based on concentration in water is the least toxic to aquatic biota of the 4 SPAs investigated. The constructed SSDs indicate that a concentration in water and sediment of 1 μg/L and 1 μg/g dry weight, respectively, would be protective of &gt;95% of the aquatic species tested. Environ Toxicol Chem 2017;36:2730–2738. © 2017 SETAC
A fluorescence in situ hybridization‐based screen allows rapid detection of adverse cytogenetic alterations in patients with acute myeloid leukemia
Authors: Sandhöfer Nadine , Metzeler Klaus H. , Kakadia Purvi M. , Pasalic Zlatana , Hiddemann Wolfgang , Neusser Michaela , Steinlein Ortrud , Fiegl Michael , Subklewe Marion , Spiekermann Karsten , Bohlander Stefan K. , Schneider Stephanie , Braess Jan 
Published: April 2017

AbstractIn adult acute myeloid leukemia (AML), the karyotype of the leukemic cell is among the strongest prognostic factors. The Medical Research Council (MRC) and the European LeukemiaNet (ELN) classifications distinguish between favorable, intermediate and adverse cytogenetic risk patients who differ in their treatment response and overall survival. Conventional cytogenetic analyses are a mandatory component of AML diagnostics but they are time‐consuming; therefore, therapeutic decisions in elderly patients are often delayed. We investigated whether a screening approach using a panel of seven fluorescence in situ hybridization (FISH) probes would allow rapid identification of adverse chromosomal changes. In a cohort of 334 AML patients, our targeted FISH screening approach identified 80% of adverse risk AML patients with a specificity of 99%. Incorporating FISH screening into diagnostic workup has the potential to accelerate risk stratification and treatment selection, particularly in older patients. This approach may allow therapeutic decisions more quickly, which benefits both patients and physicians and might save costs.
Enhanced phototoxicity of photodynamic treatment by Cx26‐composed GJIC via ROS‐, calcium‐ and lipid peroxide‐mediated pathways
Authors: Wu Deng‐Pan , Lin Tian‐Yu , Bai Li‐Ru , Huang Jin‐Lan , Zhou Yan , Zhou Nan , Zhong Sheng‐Lei , Gao Shan , Yin Xiao‐Xing 
Published: April 2017

AbstractIn spite of the promising initial treatment responses presented by photodynamic therapy (PDT), 5‐year recurrence rates remain high level. Therefore, improvement in the efficacy of PDT is needed. There are reports showing that connexin(Cx) 26‐composed gap junctional intercellular communication (GJIC) enhances the intercellular propagation of “death signal”, thereby increasing chemotherapeutic cytotoxicity. However, it is unclear whether Cx26‐formed GJIC has an effect on PDT phototoxicity. The results in the present study showed that Cx26‐composed GJ formation at high density enhances the phototoxicity of Photofrin‐PDT. When the Cx26 is not expressed or Cx26 channels are blocked, the phototoxicity in high‐density cultures substantially reduces, indicating that the enhanced PDT phototoxicity at high density is mediated by Cx26‐composed GJIC. The GJIC‐mediated increase in PDT phototoxicity was associated with ROS, calcium and lipid peroxide‐mediated stress signaling pathways. The work presents the ability of Cx26‐composed GJIC to enhance the sensitivity of malignant cells to PDT, and indicates that maintenance or increase of Cx26‐formed GJIC may be a profitable strategy towards the enhancement of PDT therapeutic efficiency. Picture: The survival response of Photofrin‐PDT in Dox‐treated (Cx26 expressing, GJ‐formed) and Dox‐untreated cells (Cx26 non‐expressing, GJ‐unformed) at high‐cell density condition.
One or two circular shapes? A binary detection for electrical capacitance tomography sensors
Authors: Oussar Yacine , Lucas Jérôme , Holé Stéphane 
Published: April 2017

AbstractImage reconstruction using engine electrical capacitance tomography sensors rises several drawbacks. Recently, the authors proposed a novel methodology dedicated to a fast detection of the configuration: size and position, of a single circular form using basic algebraic operations. However, this technique is efficient when a single form is present in the sensor cross‐section under interest. The present work proposes 2 different techniques that determine if the sensor cross‐section contains 1 or 2 circular shapes. Both methods are applied to simulated measurements. They operate much differently, and each comes with its own pros and cons. The first method considers that the sensor signal presents an axis of symmetry if a single circular object lies in the sensor. Otherwise, the symmetry is broken. It achieves a recognition rate of 73.9%. In the second method, machine‐learning techniques are used to perform a binary supervised classification. Promising rates of recognition over 99% are obtained. The present study also reveals that a 4‐electrode sensor leads to the best recognition rates with both methods. This result was also established by the authors in a different framework when dealing with physical limitations on spatial resolution in electrical capacitance tomography sensors.
Pressure dependence of peak positions, half widths, and peak intensities of methane Raman bands (ν2, 2ν4, ν1, ν3, and 2ν2)
Authors: Petrov Dmitry V. 
Published: April 2017

Results of investigation of changing peak positions, half widths, and peak intensities of Q‐branches of the ν2, 2ν4, ν1, ν3, and 2ν2 methane Raman bands are presented at pressures in the range 1–55 bar and а temperature of 298 K. The peak position of the ν2 band remains practically unchanged, and peak positions of all other bands, by analogy with the ν1 band, are shifted toward lower wavenumbers with pressure increase. It is demonstrated that the peak intensity ratio of any pair of the previously enumerated bands (except the pair of 2ν4 and 2ν2) is sensitive to pressure changes. When pressure increases, the decreased peak intensities of Q‐branches of depolarized ν2 and ν3 bands are caused by broadening of their rotational–vibrational lines, and the increased peak intensities of Q‐branches of the 2ν4 and 2ν2 bands are most likely caused by their increased interaction with the ν1 and ν3 bands. A set of data obtained will be useful for the Raman analysis of natural gas and can also be used for determination of the pressure of methane‐containing media. Copyright © 2017 John Wiley & Sons, Ltd.
New pixel driving circuit using self‐discharging compensation method for high‐resolution OLED micro displays on a silicon backplane
Authors: Kimura Kei , Onoyama Yusuke , Tanaka Taizo , Toyomura Naobumi , Kitagawa Hideyuki 
Published: April 2017

AbstractA new 4T2C pixel circuit formed on a silicon substrate is proposed to realize a high‐resolution 7.8‐μm pixel pitch AMOLED microdisplay. In order to achieve high luminance uniformity, the pixel circuit compensates its Vth variation of the MOSFET for the driving transistor internally by using self‐discharging method. Also presented are 0.5‐in Quad‐VGA and 1.25‐in wide Quad‐XGA microdisplays with the proposed pixel circuit.
Perspective correct occlusion‐capable augmented reality displays using cloaking optics constraints
Authors: Howlett Isela D. , Smithwick Quinn 
Published: April 2017

AbstractPerspective‐correct occlusion‐capable augmented reality displays are generalized using an optical cloak constraint for ray transfer analysis or simulations; any ray entering the optical system exits at the height and angle as if it passed through empty space. We analyze several systems with two‐lens, three‐lens, and four‐lens looped groups in inline, folded, and looped configurations. We design and demonstrate a four‐lens folded optical cloak and a three‐lens inverted cloak with an erecting prism.
A new path in defining light parameters for hair growth: Discovery and modulation of photoreceptors in human hair follicle
Authors: Buscone Serena , Mardaryev Andrei N. , Raafs Bianca , Bikker Jan W. , Sticht Carsten , Gretz Norbert , Farjo Nilofer , Uzunbajakava Natallia E. , Botchkareva Natalia V. 
Published: April 2017

Background and ObjectiveThough devices for hair growth based on low levels of light have shown encouraging results, further improvements of their efficacy is impeded by a lack of knowledge on the exact molecular targets that mediate physiological response in skin and hair follicle. The aim of this study was to investigate the expression of selected light‐sensitive receptors in the human hair follicle and to study the impact of UV‐free blue light on hair growth ex vivo.Material and MethodsThe expression of Opsin receptors in human skin and hair follicles has been characterized using RT‐qPCR and immunofluorescence approaches. The functional significance of Opsin 3 was assessed by silencing its expression in the hair follicle cells followed by a transcriptomic profiling. Proprietary LED‐based devices emitting two discrete visible wavelengths were used to access the effects of selected optical parameters on hair growth ex vivo and outer root sheath cells in vitro.ResultsThe expression of OPN2 (Rhodopsin) and OPN3 (Panopsin, Encephalopsin) was detected in the distinct compartments of skin and anagen hair follicle. Treatment with 3.2 J/cm2 of blue light with 453 nm central wavelength significantly prolonged anagen phase in hair follicles ex vivo that was correlated with sustained proliferation in the light‐treated samples. In contrast, hair follicle treatment with 3.2 J/cm2 of 689 nm light (red light) did not significantly affect hair growth ex vivo. Silencing of OPN3 in the hair follicle outer root sheath cells resulted in the altered expression of genes involved in the control of proliferation and apoptosis, and abrogated stimulatory effects of blue light (3.2 J/cm2; 453 nm) on proliferation in the outer root sheath cells.ConclusionsWe provide the first evidence that (i) OPN2 and OPN3 are expressed in human hair follicle, and (ii) A 453 nm blue light at low radiant exposure exerts a positive effect on hair growth ex vivo, potentially via interaction with OPN3. Lasers Surg. Med. 49:705–718, 2017. © 2017 Wiley Periodicals, Inc.
Assisted reproductive technology in Japan: a summary report of 1992–2014 by the Ethics Committee, Japan Society of Obstetrics and Gynecology
Authors: Irahara Minoru , Kuwahara Akira , Iwasa Takeshi , Ishikawa Tomonori , Ishihara Osamu , Kugu Koji , Sawa Rintaro , Banno Kouji , Saito Hidekazu 
Published: April 2017

AbstractAimThe Japan Society of Obstetrics and Gynecology implemented a registry report system for the clinical practice of assisted reproductive technology in 1986. The aggregated results from 1992 to 2014 are reported herein.Methods and ResultsThe total number of registered treatments was 393 745 cycles, of which 66 550 were pregnancy cycles and 46 008 were cycles with a live birth. Compared to the number of registered treatments in 2008, when the cycle‐based registry was newly introduced, there was a 2.07‐fold increase in the total number of treatments and a 2.25‐fold increase in the number of cycles with a live birth. As the average age of patients who receive assisted reproductive technology has become markedly higher year by year, the most common age of those patients who received assisted reproductive technology in 2014 was 40 years.ConclusionThe total numbers of both assisted reproductive technology treatments and assisted reproductive technology live births are likely to be higher in the future. In addition, the trend toward aging patients seems to be continuing into the future.
Morphological Effect in Photocatalytic Degradation of Direct Blue over Mesoporous TiO2 catalysts
Authors: Zhang Han , Zhang Hui , Zhu Pengfei , Huang Fei 
Published: April 2017

AbstractThe correlation of photo‐catalyst morphological structure and catalytic performance is one of the biggest challenges in the photo‐catalysis field. This work address a thorough investigation on the relationship between catalyst morphological structure and catalytic performance for the degradation of Direct Blue under ultraviolet light illumination. Four anatase Titanium dioxide catalysts with a slice‐, bipyramids‐, daisy‐, and sphere‐like morphologies were prepared by hydrothermal methods and well characterized by a serial of characterization techniques. By evaluating the photo‐catalytic performance over four kinds of TiO2 with different morphologies, the structure‐performance relationship of degradation of Direct Blue could be well illustrated. The degradation efficiency of TiO2 catalyst did much depend on the structure of catalyst shapes. The daisy‐like TiO2 catalyst exhibited the most excellent catalytic performance for the degradation of DB, which was attributed to the lowest band gap energy evidenced by UV‐vis spectrum.
Phylogenetic Insight into Zika and Emerging Viruses for a Perspective on Potential Hosts
Authors: Weber Diana S. , Alroy Karen A. , Scheiner Samuel M. 
Published: April 2017

Abstract
Global viral diversity is substantial, but viruses that contribute little to the public health burden or to agricultural damage receive minimal attention until a seemingly unimportant virus becomes a threat. The Zika virus (ZIKV) illustrated this, as there was limited information and awareness of the virus when it was identified as a public health emergency in February 2016. Predicting which virus may pose a future threat is difficult. This is in part because significant knowledge gaps in the basic biology and ecology of an emerging virus can impede policy development, delay decision making, and hinder public health action. We suggest using a phylogenetic framework of pathogens and their infected host species for insight into which animals may serve as reservoirs. For example, examining flaviviruses closely related to ZIKV, the phylogenetic framework indicates New World monkeys are the most likely candidates to be potential reservoirs for ZIKV. Secondarily, mammals that are in close proximity to humans should be considered because of the increased opportunity for pathogen exchange. The increase in human-mediated environmental change is accelerating the probability of another previously overlooked virus becoming a significant concern. By investing in basic science research and organizing our knowledge into an evolutionary framework, we will be better prepared to respond to the next emerging infectious disease.
The psychoactive drug 25B-NBOMe recapitulates rhabdomyolysis in zebrafish larvae
Authors: Kawahara Genri , Maeda Hideyuki , Kikura-Hanajiri Ruri , Yoshida Ken-ichi , Hayashi Yukiko K. 
Published: April 2017

AbstractN-Benzyl-substituted 2C class phenethylamines (NBOMes) are psychoactive designer drugs, with strong hallucinogenic and stimulant effects, even at low doses. The designer drug, 2-(4-bromo-2, 5-dimethoxyphenyl)-N-(2-methoxybenzyl) ethanamine (25B-NBOMe) is considered to be one of the most potent agonists of the serotonin-2A (5-HT2A) receptor. Recently, we reported the first lethal case of 25B-NBOMe intoxication with severe rhabdomyolysis, concluded by clinical, pathological and toxicological analyses. There are currently no good animal models that closely recapitulate serotonin receptor-dependent rhabdomyolysis. In the present study, we created animal models of rhabdomyolysis using zebrafish larvae to study the pathomechanism of rhabdomyolysis, and demonstrated that 25B-NBOMe can simulate lethal rhabdomyolysis in this animal. Treatment of the larvae with 25B-NBOMe decreased their survival rate, locomotion, altered birefringence of the skeletal muscle and immunostainings for dystroglycan (a myoseptal protein) and myosin heavy chain (a myofibril protein), which were consistent with rhabdomyolysis. This 25B-NBOMe-induced rhabdomyolysis was inhibited by the 5-HT2Areceptor antagonists ritanserin and aripirazole, but not by the 5-HT1A + 5-HT1Breceptor antagonist propranolol and the 5-HT3receptor antagonist granisetron, indicating 5-HT2A-dependent rhabdomyolysis. The 25B-NBOMe-treated zebrafish is, therefore, a highly useful model of rhabdomyolysis for studying the pathomechanism of rhabdomyolysis as well as for therapeutic drug screening.
Numerical Analysis of Welding Residual Stress Relaxation in High-Strength Multilayer Weldment Under Fatigue Loads
Authors: Yi Hui-Jun , Lee Yong-Jun 
Published: April 2017

Abstract
The primary purpose of this investigation was to study welding residual stress relaxation by repeated loading. A coupling finite element analysis model for prediction of the welding residual stress and the mechanical stress relaxation after external repeated loads was presented. The accuracy of this model was verified through experiments. Also, it is found that the residual stress of weldment is relaxed by external loads, and the greatest amount of relaxation was obtained by early repeated loads. As the repetition count increased, the amount of relaxation became smaller than the amount of relaxation in the early stage.