bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of platelet function in patients receiving tirofiban early after primary coronary intervention
Authors: Kupó Péter , Aradi Dániel , Tornyos Adrienn , Tőkés-Füzesi Margit , Komócsi András 
Published: December 2016

Background
Following percutaneous coronary intervention, combined antiplatelet therapy is necessary. Platelet function testing (PFT) has prognostic value and may be applied in the risk assessment of acute coronary syndrome. In case of combined antiplatelet therapy, PFT may require special laboratory methods, as different antiplatelet agents may influence test results.

Materials and methods
Platelet functions were measured in stent thrombosis-segment elevation myocardial infarction patients receiving aspirin, clopidogrel, and tirofiban. The first sampling was obtained immediately after the termination of administration of tirofiban. The second sample was drawn at a randomly assigned time between 1 and 6 h. The third sampling was done after a minimum of 24 h of tirofiban cessation. Adenosine diphosphate (ADP)- and thrombin receptor-activating peptide (TRAP)-induced aggregations were measured.

Results
Thirty-seven patients were included. Both TRAP- and ADP-induced aggregation values were significantly lower immediately after tirofiban termination, than after 24 h [TRAP: 26.41 ± 25.00 units (U) vs. 109.86 ± 23.69 U, p < 0.0001; ADP: 17.43 ± 10.10 U vs. 43.92 ± 23.35 U, p ≤ 0.0001]. Elimination half-life of tirofiban and clopidogrel were 1.34 ± 0.49 and 1.269 ± 0.78, respectively.

Conclusion
ADP-induced residual platelet reactivity is significantly influenced by the presence of concurrent glycoprotein IIb/IIIa inhibitor. In patients receiving combined antiplatelet treatment, ADP-receptor-specific efficiency measurements are valid only after total elimination of GPIIb/IIIa inhibitors.
Lipidek és az agyérbetegség – Új lehetőségek az LDL-koleszterin-szint csökkentésére
Authors: Lovadi Emese , Csécsei Péter , Lovig Csenge , Karádi Zsófia , Szapáry László 
Published: December 2016

Abstract: Stroke is the third most common cause of death worldwide following myocardial infaction and malignancies, furthermore, its functional outcome is the worst of all conditions. Cholesterol, especially LDL-cholesterol plays a key role in the formation of atherosclerotic plaques. It has been verified recently that escalating incidence and mortality of cerebrovascular diseases are proportional to increased levels of LDL-cholesterol. Statin therapy undeniably reduces the risk of stroke, however other methods for decreasing lipid levels have not been proved significantly effective. Preventive effect of high-dose statin treatment is without doubt, although administration of such high dosage might require special precautions for patients with prior intracerebral hemorrhage and it also risks development of incident diabetes. The recently published IMPROVE-IT study is the first to prove that the addition of ezetimibe as a non-statin type drug, to statin treatment contributes to further reduction of LDL-cholesterol. The combination treatment results in additional decrease in the incidence and mortality of cerebrovascular events, without any expansion in the number or adverse effects. These results confirm the importance of any further reduction of LDL-cholesterol levels. Achieving target values with statin-ezetimibe combination allows administration of low to moderate dose of statin, which decreases risks of adverse effects related to high-dose statin therapy. Orv. Hetil., 2016, 157(52), 2059–2065.
Reliability of Oronasal Fistula Classification
Authors: Sitzman Thomas J. , Allori Alexander C. , Matic Damir B. , Beals Stephen P. , Fisher David M. , Samson Thomas D. , Marcus Jeffrey R. , Tse Raymond W. ,   The Americleft Task Force Surgeon Subgroup
Published: December 2016

Objective: Oronasal fistula is an important complication of cleft palate repair that is frequently used to evaluate surgical quality, yet reliability of fistula classification has never been examined. The objective of this study was to determine the reliability of oronasal fistula classification both within individual surgeons and between multiple surgeons. Design: Using intraoral photographs of children with repaired cleft palate, surgeons rated the location of palatal fistulae using the Pittsburgh Fistula Classification System. Intrarater and interrater reliability scores were calculated for each region of the palate. Participants: Eight cleft surgeons rated photographs obtained from 29 children. Results: Within individual surgeons reliability for each region of the Pittsburgh classification ranged from moderate to almost perfect (κ = .60-.96). By contrast, reliability between surgeons was lower, ranging from fair to substantial (κ = .23-.70). Between-surgeon reliability was lowest for the junction of the soft and hard palates (κ = .23). Within-surgeon and between-surgeon reliability were almost perfect for the more general classification of fistula in the secondary palate (κ = .95 and κ = .83, respectively). Conclusions: This is the first reliability study of fistula classification. We show that the Pittsburgh Fistula Classification System is reliable when used by an individual surgeon, but less reliable when used among multiple surgeons. Comparisons of fistula occurrence among surgeons may be subject to less bias if they use the more general classification of “presence or absence of fistula of the secondary palate” rather than the Pittsburgh Fistula Classification System.
PEMANFAATAN TEKNOLOGI GOOLE MAPS API UNTUK APLIKASI LAPORAN KRIMINAL BERBASIS ANDROID PADA POLRESTABES MAKASSAR
Authors: Rismayani Rismayani 
Published: December 2016

<p>Polrestabes Makassar adalah institusi negara yang berada di bawah naungan kepolisian daerah Sulawesi Selatan yang memiliki tugas dan tanggung jawab untuk melayani masyarakat kota Makassar dalam proses penanganan berbagai macam permasalahan keamanan dan kriminalitas pada masyarakat kota Makassar. Adapun permasalahan pada penelitian ini adalah bagaimana masyarakat dapat melaporkan tindak kriminal yang terjadi di sekitar mereka tanpa harus datang ke kantor polisi dan bagaimana aparat dapat menerima langsung laporan kriminal dari masyarakat tanpa harus bertemu dan dapat melihat kejadian dari foto yang dikirimkan serta dapat mengetahui lokasi kejadian tindak kriminal di wilayah kota Makassar. Tujuan dari penelitian ini adalah membuat aplikasi berbasis android dengan memanfaatkan teknologi Google Maps API untuk mengirim laporan kriminal dalah bentuk foto serta mengirimkan lokasi kejadian tindak kriminal dari masyarakat ke aparat kepolisian. Adapun metode atau teknologi yang digunakan adalah Google Maps API dan berbasis Android, google maps api adalah adalah sebuah jasa peta global virtual gratis dan online yangdisediakan oleh perusahaan Google. Google Maps yang dapat ditemukan di alamat http://maps.google.com dan berbasis android adalah sistem operasi berbasis Linux yang dirancang untuk perangkat bergerak layar sentuh seperti telepon pintar dan komputer tablet. Hasil dari penelitian ini adalah dengan adanya aplikasi tersebut maka masyarakat dapat melaporkan tindak kriminal yang terjadi di sekitar mereka tanpa harus datang ke kantor polisi dan memudahkan para aparat kepolisian untuk melihat laporan kriminal dari masyarakat dengan melihat gambar dan lokasi kejadian kriminal.</p>
Clinical and laboratory profile of children with tubercular meningitis admitted in tertiary care centre of Kumaun region, Uttarakhand, India
Authors: Goyal Garima , Arya Ajay Kumar 
Published: December 2016

Background: Tuberculous meningitis (TBM) is an important cause of hospital admission, death and neurological disability in India. Delay in diagnosis is an important cause of morbidity and mortality.Methods: 80 cases with meningitis 1 month-16 year were enrolled, 44 diagnosed as TBM, studied in detail about clinical and laboratory profile. The data was analyzed by statistical test SPSS 21 and Chi square test was applied.Results: Peak age incidence 11-16 year. Youngest patient 3 month. Male: female ratio 0.8:1. Majority of patients had fever, altered sensorium, vomiting, headache, seizures. Neurological deficit found was loss of speech, right sided weakness, and diplopia. 36.3% patients were comatose. Cranial nerve palsy was present in 57% cases, 6th nerve being the commonest. Papilloedema common than optic atrophy. Motor deficit like hemiplegia (4.5%). Maximum cases were in stage III BMRC. CSF findings were reduced glucose level in 47.7% of cases (mean 54.5 mg/dl), elevated protein (mean 116.9 mg/dl), lymphocytic pleocytosis (mean value 102.46) (>60% lymphocytes). CT scan abnormality in 75% cases. Hydrocephalus being the most common finding.Conclusions: TBM one of most serious illness. Majority patients presented in stage 3 with neurological deficit, as this are tertiary care centre and due to difficult geographic terrain patient presents at late stage. High index of suspicion to diagnose TBM at early stage. CSF analysis continues to be a key in establishing the diagnosis. One should not wait for the microbiological proof to start the therapy. Mantoux and radiological tests can be good supportive investigation. Early diagnosis and treatment can make complete recovery even in comatose patients.
Predictors of meningitis in children presenting with first episode of febrile seizure
Authors: D. Suresh Reddy , S. Habib Khan , Hegde Pavan 
Published: December 2016

Background: Febrile seizure is the most common cause of seizures in infants and toddlers presenting to the paediatric emergency department. Two to five percent of children experience at least one or more episodes of febrile seizures. Simple febrile seizures are benign and self-limiting. They have good prognosis and carry very low risk for epilepsy. Probability of acute bacterial meningitis presenting as fever with seizures varies from 0.6% to 6.7%. The American Academy of Paediatrics (AAP) strongly recommends lumbar puncture (for CSF analysis) in the work up of every child under 18 months of age with a first episode of febrile seizure to rule out acute bacterial meningitis. The objective of this study was to determine the occurrence of meningitis in children who presented with first episode of seizure and fever and also the predictors of meningitis among them.Methods: The records of children admitted to Father Muller Medical College and Hospital between 1st January 2014 to 31st December 2015 were reviewed. All children between 6 months to 6 years of age having first episode of convulsions, associated with fever were included in the study and subjected to retrospective analysis of data collected from the case sheets. Results: Our study included 105 children with febrile seizures, 49 children had simple febrile seizures (SFS) and 56 children presented as atypical febrile seizures (AFS). Lumbar puncture was performed in 43 children (15 with SFS and 28 with AFS). The CSF analysis was normal in all the children who presented as simple febrile seizures. There was 25.87% prevalence of meningitis in children with atypical febrile seizures who underwent lumbar puncture. The CSF yield suggestive of bacterial meningitis was as high as 50% in children below 1 year in whom lumbar puncture was done.Conclusions: Children presenting with Atypical/Complex febrile seizures who were treated with antibiotics have more likelihood of having meningitis rather than those presenting with simple febrile seizures.
To study the correlation of high sensitivity C reactive protein levels with asthma control in children
Authors: Ramakrishnan Nithiyanantham , Sivathanu Shobhana , Sampath Sowmya , JH Suresh David , Mohan Thuthi 
Published: December 2016

Background: Childhood asthma appears to be increasing in prevalence despite advancements in the care of asthma. In asthma, local as well as systemic inflammation contributes to the pathogenesis. Thus successful management depends on controlling this inflammation by appropriate doses of inhaled corticosteroids. High sensitivity C reactive protein (hsCRP) is an easily measurable marker of inflammation and its level can be used as a diagnostic tool in assessing control of asthma. The objective of this study was study the correlation of serum hsCRP levels with asthma control in childrenMethods: It is an observational study conducted in the Pediatric asthma clinic of a Government Medical College in south India. The study population consisted of 75 asthmatic children aged 5-15 years. Children with persistent asthma were classified into three groups based on GINA guidelines. Serum hsCRP levels were measured in all the three groups.Results: Among the 75 children 33% belonged to controlled group, 35% to uncontrolled group and 33% to partly controlled group. There was a significant difference in hsCRP levels between controlled and uncontrolled groups. The mean value of hsCRP in controlled group was 0.93±1.3 mg/L whereas in the uncontrolled group it was 2.73±2.46 mg/L. Higher levels of hsCRP were found in the uncontrolled asthma group.Conclusions: There is an inverse correlation between hsCRP levels and asthma control in children. High hsCRP levels have a potential to be used as a surrogate marker for poor control of asthma and can thus be used as a guide for adjustment of dosage of inhaled corticosteroids.
Study of risk factors of neonatal thrombocytopenia
Authors: Tirupathi Keerthi , Swarnkar Keerti , Vagha Jayant 
Published: December 2016

Background: Neonatal thrombocytopenia (platelet count < 1.5 lac/µl) is the commonest haematological abnormality encountered in neonatal intensive care unit (NICU). Thrombocytopenia if not detected can result in devastating complications. Determining the risk factors of thrombocytopenia enables us to prevent the inevitable and irreversible complications. The present study highlights the pattern, severity and risk factors of neonatal thrombocytopenia in our hospital.Methods: Prospective observational study was conducted on 200 neonates with thrombocytopenia admitted in NICU of our hospital. Maternal and neonatal risk factors were recorded. Neonates were grouped based on the severity of thrombocytopenia. The risk factors were compared with severity of thrombocytopenia.Results: 200 neonates with thrombocytopenia were divided into three groups based on severity of thrombocytopenia. 81% of babies had moderate to severe thrombocytopenia. The most common maternal predisposing factors were pregnancy induced hypertension (PIH), premature rupture of membranes (PROM) and anemia.62.5% babies were low birth weight babies and they had severe thrombocytopenia. 56% babies had late onset neonatal thrombocytopenia and 44% had early onset thrombocytopenia. The most common neonatal risk factors were sepsis in 48.5% babies and birth asphyxia in 20% babies.Conclusions: The severity of neonatal thrombocytopenia in our NICU was moderate to severe type. PIH, PROM and anemia were the commonest maternal risk factors. Preterm and low birth weight babies had severe thrombocytopenia. Sepsis and birth asphyxia were the commonest neonatal risk factors. Birth asphyxia was associated with early onset neonatal thrombocytopenia and sepsis was associated with late onset thrombocytopenia. Severe thrombocytopenia can be used as a prognostic indicator in sick neonates.
Knowledge and attitude about sexually transmitted infections among women in reproductive age group residing in the urban slums
Authors: Sharma Prajna , Sherkhane Mayur S. 
Published: December 2016

Background: Sexually transmitted diseases (STDs) are group of disease primarily affecting sexually active population and has lead to a major public health problem in the reproductive age group (15-45 years), which are largely acquired through sexual act or close contact with genitals leading to potentially devastating effects. Aims and Objectives: To assess the knowledge and attitude towards STDs among women of reproductive age group residing in urban slums and also to provide an insight to the reproductive and sexual health needs through health education sessions.Methods: It is a community based cross sectional study and was conducted in the urban slums attached to a tertiary care hospital. House to house survey was done and women of reproductive age group residing in urban slums were selected and data was collected using predesigned and pretested proforma. Results: A total of 180 women were enrolled, of which 87.78% opined blood transfusion as major mode of transmission and 86.11% as unprotected sexual intercourse. 32.78% women told that fever is the commonest symptom, followed by menstrual irregularities (38.89%). 72.78% told that STDs can be diagnosed by blood examination. 32.78% opined that STDs can be prevented by using condoms and 27.22% told by giving sex education. 68.89% were willing to get screened for STDs. Overall literates were more aware about STDs compared to illiterates (p<0.001)Conclusions:Information, Education and Communication (IEC) activities should be promoted, so that it reaches the mass at a negligible cost.
A community based cross-sectional study to assess malnutrition among elderly population residing in urban and rural areas of a district in Karnataka, India
Authors: B. G. Ananthesh , Bathija Geeta V. , Bant Dattatraya D. 
Published: December 2016

Background: The geriatric age group is the fastest-growing segment of the population in most of the countries. Malnutrition has emerged as an important problem among elderly. Nutritional status of the elderly population is seldom focused upon. This study was conducted to evaluate malnutrition among elderly population and its association with sociodemographic correlates and to compare the nutritional status of elderly living in the urban and rural areas of a district in Karnataka. Methods:A cross-sectional study was conducted among 102 urban and 102 rural residents of Dharwad district for a period of 4 months using pre-designed and structured questionnaire which include details of sociodemographic data and nutritional status which was assessed using the Mini Nutritional Assessment (MNA) questionnaire.Results: The prevalence of malnutrition was found to be 18.6 %. Among 204 subjects, 42.6% were well nourished and 38.7% were at risk of malnutrition. Elderly living in rural are more malnourished than urban areas. And 12.7% of elderly living in urban area were obese, whereas only 7.8% of rural elderly were obese. A significant association was found between nutritional status with age, literacy and the socioeconomic status of the elderly.Conclusions:High prevalence of under-nutrition (at risk of malnutrition and malnutrition) was found in our study. With higher percentages in elderly living in rural area, among illiterates and with low socioeconomic status. This study emphasizes increased need to give attention to the nutritional needs of elderly and also to screen and support elderly with malnutrition.
An educational intervention on the risk factors of lifestyle diseases among men aged 30-50 years in an urban slum in Coimbatore, Tamil Nadu, India
Authors: S. Hamsaa Nandini , S. Karthikeyan 
Published: December 2016

Background: Lifestyle diseases like hypertension, atherosclerosis, coronary heart disease (CAD), type –II diabetes mellitus, ischemic stroke are Non -communicable diseases leading to premature sickness, disability and death. To determine the risk factors of lifestyle diseases like hypertension and diabetes mellitus and to impart health education on the risk factors of lifestyle diseases and to determine the impact of health education.Methods: A educational interventional study was conducted in a randomly selected urban slum in Peelamedu, Coimbatore funded by ICMR STS.100 Men in the age group of 30-50 years were administered questionnaire to determine the risk factors of lifestyle diseases. Health education was given to the respondents regarding risk factors. The same questionnaire was given to the respondents after the health education to determine the impact of health education. Statistical analysis was performed by using SPSS version 20. Prevalence of risk factors was presented in percentage. Paired T test was used to find out the effectiveness of Health Education.Results: Among the study population, the risk factors for life style diseases in our study are smoking (39%), alcohol intake (27%), lack of physical activity (40%), overweight (36%), obesity (14%). The impact of health education on risk factors of lifestyle disease and it was statistically significant with smoking (p=.000), alcohol (p=.02), physical activity (p=.001) and not significant with BMI (p=.71).Conclusions: Regular health checks can be done to improve the frequency of preventive care and support for behavior change. Effective implementation of lifestyle modifications behavior like healthy diet intake, avoidance of high caloric foods, promoting physical activity help in preventing future complications as a part of primary preventive strategies at primary care level. The importance of lifestyle modifications should be reinforced.
Frequency of supplement and multi-vitamins uses rate among Ardabil medical students, Iran
Authors: Ojaghi Habib , Abbasi Vahid , Masoumi Rahim , Barak Manouchehr , Kahnamouei-aghdam Fariba 
Published: December 2016

Background: Today, the tendency to use supplements such as multivitamins and minerals in different communities and especially among young people and students has been increased. The aim of this study was to investigate the consumption rate of supplements and multi-vitamin pills among Ardabil medical college students.Methods: Methods: This descriptive-analytical study has been done on 100 students which selected randomly from Ardabil medical university. Data Collected by a questionnaire and analyzed by statistical methods in SPSS.16.Results: 47% of students were male and the mean age of them were 20.8±1.6. 90% of all students were single and 62% have moderate economic level. 47% of students used the supplement and multi-vitamin pills in recent year which 42.6% of them pointed to “lack of vitamin” as the main reason for their use. 38.3% of students which used supplement pills pointed that their own physician have main role in their supplements usage.Conclusions: Results showed that the prevalence of using supplement and multi-vitamin pills among medical students were in moderate level which need for doing more research and educational interventions in future for decreasing rate of supplement usage among them.
Substance abuse pattern among medical college students in Tumkur, Karnataka, India: a cross sectional study
Authors: Mir Ashiq Rashid , S. H. Mahesh , M. S. Rajanna , J. Ashok , Singh Debeshwar 
Published: December 2016

Background: Globally, there are 2 billion alcohol users, 1.3 billion smokers and 185 million are drug users. These are accounting for 12.4% of all deaths worldwide. The doctors are vulnerable to substance abuse due to their ready accessibility to the substance of abuse. Medical training is identified as full of stress and it is also observed that students undergo tremendous stress during various years of medical training. Repeated use of drugs can damage essential decision making and effect judgment of actions. This could be disastrous if substance abusers are medical professionals who have direct dealing with human lives. Methods: A cross sectional study was conducted at a medical college in Tumkur district of Karnataka. A semi structured questionnaire was used to interview 379 medical students who were willing to participate.Results: Prevalence of substance abuse among the students was found to be 25.9%. Substance abuse was highest among VII term students (IIIrd year) which was 25.3%. Alcohol was the single most preferred substance of abuse which was used by 36.40% of students. Curiosity for experience (42.4%) was major reason for initiation of substance abuse. Majority of students (45.5%) attained the harmful substances through friends. 76.6% of hostellers used harmful substances.Conclusions: Prevalence of substance abuse among medical college students was high. Students preferred alcohol products and tobacco most. Hosteller students are more likely to be exposed to substance abuse.