bluuebunny/crossref_metadata_2025_split huggingface dataset:
An analogue of Vosper's theorem for extension fields
Authors: BACHOC CHRISTINE , SERRA ORIOL , ZÉMOR GILLES 
Published: January 2017

AbstractWe are interested in characterising pairs S, T of F-linear subspaces in a field extension L/F such that the linear span ST of the set of products of elements of S and of elements of T has small dimension. Our central result is a linear analogue of Vosper's Theorem, which gives the structure of vector spaces S, T in a prime extension L of a finite field F for which
\begin{linenomath}$$
\dim_FST =\dim_F S+\dim_F T-1,
$$\end{linenomath}
when dimFS, dimFT ⩾ 2 and dimFST ⩽ [L : F] − 2.
Impact of dietary fat composition on prediabetes: a 12-year follow-up study
Authors: Krishnan Sridevi , Steffen Lyn M , Paton Chad M , Cooper Jamie A 
Published: January 2017

AbstractObjectiveDietary fatty acid composition likely affects prediabetic conditions such as isolated impaired fasting glucose (IFG) or impaired glucose tolerance (IGT); however, this risk has not been evaluated in a large population nor has it been followed prospectively.DesignDiet, physical activity, anthropometric, socio-economic and blood glucose data from the Atherosclerosis Risk in Communities (ARIC) study were obtained from BioLINCC. Cox proportional hazards regression models were used to evaluate associations of dietary SFA, MUFA, PUFA,n-3 fatty acid (FA) andn-6 FA intakes with incidence of one (isolated IFG) or two (IFG with IGT) prediabetic conditions at the end of 12-year follow-up.SettingStudy volunteers were from counties in North Carolina, Mississippi, Minnesota and Maryland, USA.SubjectsData from 5288 volunteers who participated in the ARIC study were used for all analyses reported herein.ResultsThe study population was 62% male and 84 % white, mean age 53·5 (sd5·7) years and mean BMI 26·2 (sd4·6) kg/m2. A moderately high intake of dietary MUFA (10–15 % of total daily energy) was associated with a 10 % reduced risk of isolated IFG incidence, while a high intake ofn-3 FA (>0·15 % of total daily energy) was associated with a 10 % increase in risk. Curiously, moderately high intake ofn-6 PUFA (4–5 % of total daily energy) was associated with a 12 % reduction in IFG and IGT incidence.ConclusionsMUFA,n-3 andn-6 FA contribute differently to the development of isolated IFGv. IFG with IGT; and their mechanism may be more complex than originally proposed.
Unintended targeting of Dmp1-Cre reveals a critical role for Bmpr1a signaling in the gastrointestinal mesenchyme of adult mice
Authors: Lim Joohyun , Burclaff Joseph , He Guangxu , Mills Jason C , Long Fanxin 
Published: January 2017

AbstractCre/loxP technology has been widely used to study cell type-specific functions of genes. Proper interpretation of such data critically depends on a clear understanding of the tissue specificity of Cre expression. The Dmp1-Cre mouse, expressing Cre from a 14-kb DNA fragment of the mouse Dmp1 gene, has become a common tool for studying gene function in osteocytes, but the presumed cell specificity is yet to be fully established. By using the Ai9 reporter line that expresses a red fluorescent protein upon Cre recombination, we find that in 2-month-old mice, Dmp1-Cre targets not only osteocytes within the bone matrix but also osteoblasts on the bone surface and preosteoblasts at the metaphyseal chondro-osseous junction. In the bone marrow, Cre activity is evident in certain stromal cells adjacent to the blood vessels, but not in adipocytes. Outside the skeleton, Dmp1-Cre marks not only the skeletal muscle fibers, certain cells in the cerebellum and the hindbrain but also gastric and intestinal mesenchymal cells that express Pdgfra. Confirming the utility of Dmp1-Cre in the gastrointestinal mesenchyme, deletion of Bmpr1a with Dmp1-Cre causes numerous large polyps along the gastrointestinal tract, consistent with prior work involving inhibition of BMP signaling. Thus, caution needs to be exercised when using Dmp1-Cre because it targets not only the osteoblast lineage at an earlier stage than previously appreciated, but also a number of non-skeletal cell types.
Dynamic behaviour of human neuroepithelial cells in the developing forebrain
Authors: Subramanian Lakshmi , Bershteyn Marina , Paredes Mercedes F. , Kriegstein Arnold R. 
Published: January 2017

AbstractTo understand how diverse progenitor cells contribute to human neocortex development, we examined forebrain progenitor behaviour using timelapse imaging. Here we find that cell cycle dynamics of human neuroepithelial (NE) cells differ from radial glial (RG) cells in both primary tissue and in stem cell-derived organoids. NE cells undergoing proliferative, symmetric divisions retract their basal processes, and both daughter cells regrow a new process following cytokinesis. The mitotic retraction of the basal process is recapitulated by NE cells in cerebral organoids generated from human-induced pluripotent stem cells. In contrast, RG cells undergoing vertical cleavage retain their basal fibres throughout mitosis, both in primary tissue and in older organoids. Our findings highlight developmentally regulated changes in mitotic behaviour that may relate to the role of RG cells to provide a stable scaffold for neuronal migration, and suggest that the transition in mitotic dynamics can be studied in organoid models.
Evidence of preserved collagen in an Early Jurassic sauropodomorph dinosaur revealed by synchrotron FTIR microspectroscopy
Authors: Lee Yao-Chang , Chiang Cheng-Cheng , Huang Pei-Yu , Chung Chao-Yu , Huang Timothy D. , Wang Chun-Chieh , Chen Ching-Iue , Chang Rong-Seng , Liao Cheng-Hao , Reisz Robert R. 
Published: January 2017

AbstractFossilized organic remains are important sources of information because they provide a unique form of biological and evolutionary information, and have the long-term potential for genomic explorations. Here we report evidence of protein preservation in a terrestrial vertebrate found inside the vascular canals of a rib of a 195-million-year-old sauropodomorph dinosaur, where blood vessels and nerves would normally have been present in the living organism. The in situ synchrotron radiation-based Fourier transform infrared (SR-FTIR) spectra exhibit the characteristic infrared absorption bands for amide A and B, amide I, II and III of collagen. Aggregated haematite particles (α-Fe2O3) about 6∼8 μm in diameter are also identified inside the vascular canals using confocal Raman microscopy, where the organic remains were preserved. We propose that these particles likely had a crucial role in the preservation of the proteins, and may be remnants partially contributed from haemoglobin and other iron-rich proteins from the original blood.
Tailoring the photon spin via light–matter interaction in liquid-crystal-based twisting structures
Authors: Ming Yang , Chen Peng , Ji Wei , Wei Bing-yan , Lee Chun-hong , Lin Tsung-hsien , Hu Wei , Lu Yan-qing 
Published: January 2017

AbstractWe demonstrate the photonic spin Hall effect in a system comprising designable liquid crystal materials. The photoalignment technique provides an effective approach to control the directors of the liquid crystal molecules. Twisting structures with different transverse distributions are conveniently introduced into the liquid crystal plates for tailoring the spin–orbit coupling process to present various photonic spin Hall effect phenomena. The light–matter interaction in the twisting mediums is described with a Schrödinger-like equation. The photonic spin Hall effect considered in the study is explained as the result of an effective magnetic field acting on a pseudospin. Moreover, owing to the designability of the liquid crystal system, it is a potential platform for Hamiltonian engineering. Several valuable multiple quantum systems are possible to be presented in classical analogies.
Skeletal Site-specific Effects of Zoledronate on in vivo Bone Remodeling and in vitro BMSCs Osteogenic Activity
Authors: Gong Xue , Yu Wanlu , Zhao Hang , Su Jiansheng , Sheng Qing 
Published: January 2017

AbstractBisphosphonate-related osteonecrosis of the jaw (BRONJ) has been associated with long-term oral or intravenous administration of nitrogen-containing bisphosphonates (BPs). However, the pathogenesis of BRONJ remains unknown, and definitively effective treatment has not yet been established. Bisphosphonate-related osteonecrosis (BRON) tends to occur in maxillofacial bones. Why this occurs is still unclear. Here we show that zoledronate (Zol) treatment suppresses alveolar bone remodeling after tooth typical clinical and radiographic hallmarks of the human BRONJ, whereas enhances peripheral bone quantity in bone remodeling following injury in the same individuals, shown as increased cortical bone thickness, increased trabecular bone formation and accelerated bone defect repair. We find that the RANKL/OPG ratio and Wnt-3a expression are suppressed at the extracted alveolar sites in Zol-treated rats compared with those at the injured sites of peripheral bones. We also show that Zol-treated bone marrow stromal cell (BMSCs) derived from jaw and peripheral bones exhibit differences in cell proliferation, alkaline phosphatase (ALP) activity, expression of osteogenic and chondrogenic related marker genes, and in vivo bone formation capacity. Hopefully, this study will help us better understand the pathogenesis of BRONJ, and deepen the theoretical research.
SNP variants associated with non-Hodgkin lymphoma (NHL) correlate with human leukocyte antigen (HLA) class II expression
Authors: Ten Lik-Chin , Chin Yoon-Ming , Tai Mei-Chee , Chin Edmund Fui-Min , Lim Yat-Yuen , Suthandiram Sujatha , Chang Kian-Meng , Ong Tee-Chuan , Bee Ping-Chong , Mohamed Zahurin , Gan Gin-Gin , Ng Ching-Ching 
Published: January 2017

AbstractLarge consortia efforts and genome-wide association studies (GWASs) have linked a number of genetic variants within the 6p21 chromosomal region to non-Hodgkin lymphoma (NHL). Complementing these efforts, we genotyped previously reported SNPs in the human leukocyte antigen (HLA) class I (rs6457327) and class II (rs9271100, rs2647012 and rs10484561) regions in a total of 1,145 subjects (567 NHL cases and 578 healthy controls) from two major ethnic groups in Malaysia, the Malays and the Chinese. We identified a NHL-associated (PNHL_add = 0.0008; ORNHL_add = 0.54; 95% CI = 0.37–0.77) and B-cell associated (PBcell_add = 0.0007; ORBcell_add = 0.51; 95% CI = 0.35–0.76) SNP rs2647012 in the Malaysian Malays. In silico cis-eQTL analysis of rs2647012 suggests potential regulatory function of nearby HLA class II molecules. Minor allele rs2647012-T is linked to higher expression of HLA-DQB1, rendering a protective effect to NHL risk. Our findings suggest that the HLA class II region plays an important role in NHL etiology.
The hypothalamic NPVF circuit modulates ventral raphe activity during nociception
Authors: Madelaine Romain , Lovett-Barron Matthew , Halluin Caroline , Andalman Aaron S. , Liang Jin , Skariah Gemini M. , Leung Louis C. , Burns Vanessa M. , Mourrain Philippe 
Published: January 2017

AbstractRFamide neuropeptide VF (NPVF) is expressed by neurons in the hypothalamus and has been implicated in nociception, but the circuit mechanisms remain unexplored. Here, we studied the structural and functional connections from NPVF neurons to downstream targets in the context of nociception, using novel transgenic lines, optogenetics, and calcium imaging in behaving larval zebrafish. We found a specific projection from NPVF neurons to serotonergic neurons in the ventral raphe nucleus (vRN). We showed NPVF neurons and vRN are suppressed and excited by noxious stimuli, respectively. We combined optogenetics with calcium imaging and pharmacology to demonstrate that stimulation of NPVF cells suppresses neuronal activity in vRN. During noxious stimuli, serotonergic neurons activation was due to a suppression of an inhibitory NPVF-ventral raphe peptidergic projection. This study reveals a novel NPVF-vRN functional circuit modulated by noxious stimuli in vertebrates.
Midcontinental Native American population dynamics and late Holocene hydroclimate extremes
Authors: Bird Broxton W. , Wilson Jeremy J. , Gilhooly III William P. , Steinman Byron A. , Stamps Lucas 
Published: January 2017

AbstractClimate’s influence on late Pre-Columbian (pre-1492 CE), maize-dependent Native American populations in the midcontinental United States (US) is poorly understood as regional paleoclimate records are sparse and/or provide conflicting perspectives. Here, we reconstruct regional changes in precipitation source and seasonality and local changes in warm-season duration and rainstorm events related to the Pacific North American pattern (PNA) using a 2100-year-long multi-proxy lake-sediment record from the midcontinental US. Wet midcontinental climate reflecting negative PNA-like conditions occurred during the Medieval Climate Anomaly (950–1250 CE) as Native American populations adopted intensive maize agriculture, facilitating population aggregation and the development of urban centers between 1000–1200 CE. Intensifying midcontinental socio-political instability and warfare between 1250–1350 CE corresponded with drier positive PNA-like conditions, culminating in the staggered abandonment of many major Native American river valley settlements and large urban centers between 1350–1450 CE during an especially severe warm-season drought. We hypothesize that this sustained drought interval rendered it difficult to support dense populations and large urban centers in the midcontinental US by destabilizing regional agricultural systems, thereby contributing to the host of socio-political factors that led to population reorganization and migration in the midcontinent and neighboring regions shortly before European contact.
Rewiring carotenoid biosynthesis in plants using a viral vector
Authors: Majer Eszter , Llorente Briardo , Rodríguez-Concepción Manuel , Daròs José-Antonio 
Published: January 2017

AbstractPlants can be engineered to sustainably produce compounds of nutritional, industrial or pharmaceutical relevance. This is, however, a challenging task as extensive regulation of biosynthetic pathways often hampers major metabolic changes. Here we describe the use of a viral vector derived from Tobacco etch virus to express a whole heterologous metabolic pathway that produces the health-promoting carotenoid lycopene in tobacco tissues. The pathway consisted in three enzymes from the soil bacteria Pantoea ananatis. Lycopene is present at undetectable levels in chloroplasts of non-infected leaves. In tissues infected with the viral vector, however, lycopene comprised approximately 10% of the total carotenoid content. Our research further showed that plant viruses that express P. ananatis phytoene synthase (crtB), one of the three enzymes of the heterologous pathway, trigger an accumulation of endogenous carotenoids, which together with a reduction in chlorophylls eventually result in a bright yellow pigmentation of infected tissues in various host-virus combinations. So, besides illustrating the potential of viral vectors for engineering complex metabolic pathways, we also show a yellow carotenoid-based reporter that can be used to visually track infection dynamics of plant viruses either alone or in combination with other visual markers.
Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis
Authors: Pasanen Anu , Karjalainen Minna K. , Bont Louis , Piippo-Savolainen Eija , Ruotsalainen Marja , Goksör Emma , Kumawat Kuldeep , Hodemaekers Hennie , Nuolivirta Kirsi , Jartti Tuomas , Wennergren Göran , Hallman Mikko , Rämet Mika , Korppi Matti 
Published: January 2017

AbstractBronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic background of bronchiolitis is not well characterized. To identify polymorphisms associated with bronchiolitis, we conducted a genome-wide association study (GWAS) in which 5,300,000 single nucleotide polymorphisms (SNPs) were tested for association in a Finnish–Swedish population of 217 children hospitalized for bronchiolitis and 778 controls. The most promising SNPs (n = 77) were genotyped in a Dutch replication population of 416 cases and 432 controls. Finally, we used a set of 202 Finnish bronchiolitis cases to further investigate candidate SNPs. We did not detect genome-wide significant associations, but several suggestive association signals (p < 10−5) were observed in the GWAS. In the replication population, three SNPs were nominally associated (p < 0.05). Of them, rs269094 was an expression quantitative trait locus (eQTL) for KCND3, previously shown to be associated with occupational asthma. In the additional set of Finnish cases, the association for another SNP (rs9591920) within a noncoding RNA locus was further strengthened. Our results provide a first genome-wide examination of the genetics underlying bronchiolitis. These preliminary findings require further validation in a larger sample size.
Macroscopic liquid-state molecular hydrodynamics
Authors: Keanini R. G. , Tkacik Peter T. , Fleischhauer Eric , Shahinian Hossein , Sholar Jodie , Azimi Farzad , Mullany Brid 
Published: January 2017

AbstractExperimental evidence and theoretical modeling suggest that piles of confined, high-restitution grains, subject to low-amplitude vibration, can serve as experimentally-accessible analogs for studying a range of liquid-state molecular hydrodynamic processes. Experiments expose single-grain and multiple-grain, collective dynamic features that mimic those either observed or predicted in molecular-scale, liquid state systems, including: (i) near-collision-time-scale hydrodynamic organization of single-molecule dynamics, (ii) nonequilibrium, long-time-scale excitation of collective/hydrodynamic modes, and (iii) long-time-scale emergence of continuum, viscous flow. In order to connect directly observable macroscale granular dynamics to inaccessible and/or indirectly measured molecular hydrodynamic processes, we recast traditional microscale equilibrium and nonequilibrium statistical mechanics for dense, interacting microscale systems into self-consistent, macroscale form. The proposed macroscopic models, which appear to be new with respect to granular physics, and which differ significantly from traditional kinetic-theory-based, macroscale statistical mechanics models, are used to rigorously derive the continuum equations governing viscous, liquid-like granular flow. The models allow physically-consistent interpretation and prediction of observed equilibrium and non-equilibrium, single-grain, and collective, multiple-grain dynamics.
Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome
Authors: Chen Zhifang , Li Xiao , Zhou Jingjing , Yuan Bo , Yu Bin , Tong Dali , Cheng Cheng , Shao Yinqi , Xia Shengnan , Zhang Ran , Lyu Jingwen , Yu Xiuya , Dong Chen , Zhou Wen-Hao , Qiu Zilong 
Published: January 2017

AbstractDuplications of Methyl CpG binding protein 2 (MECP2) -containing segments lead to the MECP2 duplication syndrome, in which severe autistic symptoms were identified. Whether adult neurogenesis may play a role in pathogenesis of autism and the role of MECP2 on state determination of adult neural stem cells (NSCs) remain largely unclear. Using a MECP2 transgenic (TG) mouse model for the MECP2 duplication syndrome, we found that adult hippocampal quiescent NSCs were significantly accumulated in TG mice comparing to wild type (WT) mice, the neural progenitor cells (NPCs) were reduced and the neuroblasts were increased in adult hippocampi of MECP2 TG mice. Interestingly, we found that parvalbumin (PV) positive interneurons were significantly decreased in MECP2 TG mice, which were critical for determining fates of adult hippocampal NSCs between the quiescence and activation. In summary, we found that MeCP2 plays a critical role in regulating fate determination of adult NSCs. These evidences further suggest that abnormal development of NSCs may play a role in the pathogenesis of the MECP2 duplication syndrome.
Beyond Slurry-Cast Supercapacitor Electrodes: PAN/MWNT Heteromat-Mediated Ultrahigh Capacitance Electrode Sheets
Authors: Lee Jung Han , Kim Jeong A , Kim Ju-Myung , Lee Sun-Young , Yeon Sun-Hwa , Lee Sang-Young 
Published: January 2017

AbstractSupercapacitors (SCs) have garnered considerable attention as an appealing power source for forthcoming smart energy era. An ultimate challenge facing the SCs is the acquisition of higher energy density without impairing their other electrochemical properties. Herein, we demonstrate a new class of polyacrylonitrile (PAN)/multi-walled carbon tube (MWNT) heteromat-mediated ultrahigh capacitance electrode sheets as an unusual electrode architecture strategy to address the aforementioned issue. Vanadium pentoxide (V2O5) is chosen as a model electrode material to explore the feasibility of the suggested concept. The heteromat V2O5 electrode sheets are produced through one-pot fabrication based on concurrent electrospraying (for V2O5 precursor/MWNT) and electrospinning (for PAN nanofiber) followed by calcination, leading to compact packing of V2O5 materials in intimate contact with MWNTs and PAN nanofibers. As a consequence, the heteromat V2O5 electrode sheets offer three-dimensionally bicontinuous electron (arising from MWNT networks)/ion (from spatially reticulated interstitial voids to be filled with liquid electrolytes) conduction pathways, thereby facilitating redox reaction kinetics of V2O5 materials. In addition, elimination of heavy metallic foil current collectors, in combination with the dense packing of V2O5 materials, significantly increases (electrode sheet-based) specific capacitances far beyond those accessible with conventional slurry-cast electrodes.
Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation
Authors: Lee Minho , Lee Na Young , Chung Kyung-Sook , Cheon Se-Yun , Lee Kyung-Tae , An Hyo-Jin 
Published: January 2017

AbstractRoxatidine is an active metabolite of roxatidine acetate hydrochloride which is a histamine H2-receptor antagonist that is used to treat gastric and duodenal ulcers. In this study, we investigated the anti-allergic inflammatory effects and the underlying molecular mechanism of roxatidine in phorbol 12-myristate 13-acetate and calcium ionophore (PMACI)-stimulated human mast cells-1 (HMC-1), compound 48/80-induced anaphylactic animal model and chemical allergen-induced contact hypersensitivity (CHS) models. Roxatidine suppressed the mRNA and protein expression of inflammatory cytokines such as TNF-α, IL-6, and IL-1β in PMACI-stimulated HMC-1 and compound 48/80-induced anaphylactic mice. In addition, roxatidine attenuated PMACI-induced nuclear translocation of NF-κB and the phosphorylation of MKK3/6 and MK2, which are both involved in the p38 MAPK pathway. Furthermore, we observed that roxatidine suppressed the activation of caspase-1, an IL-1β converting enzyme, in PMACI-stimulated HMC-1 and compound 48/80-induced anaphylactic mice. In CHS model, roxatidine significantly reduced ear swelling, increased number of mast cells, production levels of cytokines and migration of dendritic cells. Our findings provide evidence that the anti-allergic inflammatory properties of roxatidine are mediated by the inhibition of NF-κB and caspase-1 activation, p38 MAPK pathway and mast cell-derived cytokine production. Taken together, the in vitro and in vivo anti-allergic inflammatory effects suggest a possible therapeutic application of roxatidine in allergic inflammatory diseases.