bluuebunny/crossref_metadata_2025_split huggingface dataset:
An enhanced bilinear pairing based authenticated key agreement protocol for multiserver environment
Authors: Sureshkumar Venkatasamy , Amin Ruhul , Anitha R 
Published: June 2017

SummaryTo circumvent using of multiple single servers, the theory of multiserver communication exists and numerous authentication protocols put forward for providing secure communication. Very recently, Amin‐Biswas proposes bilinear pairing–based multiserver scheme by describing some security pitfalls of Hsieh‐Leu protocol and claims that it is secured against related security threats. However, this paper claims that Amin‐Biswas protocol is still susceptible to off‐line identity and password guessing attack, user untraceability attack, and server masquerading attack. The cryptographic protocol should be attacks‐free for real‐time application. To achieve attacks‐free security, we put forward smart card–based multiserver authentication protocol by using the concept of bilinear pairing operation. The formal method strand space model has been used to prove the correctness of the proposed scheme. Additionally, rigorous security analysis ensures pliability of common security threats. The performance and security features of our scheme are also compared with that of the similar existing schemes. The comparison results show that our protocol achieves more security features with less complexity.
Aptamer‐based Biosensor Developed to Monitor MUC1 Released by Prostate Cancer Cells
Authors: Karpik Agnieszka E. , Crulhas Bruno P. , Rodrigues Carolina B. , Castro Gustavo R. , Pedrosa Valber A. 
Published: June 2017

AbstractElectrochemical aptasensors can detect cancer biomarkers such as mucin 1 (MUC1) to provide point‐of‐care diagnosis that is low‐cost, specific and sensitive. Herein, a DNA hairpin containing MUC1 aptamer was thiolated, conjugated with methylene blue (MB) redox tag, and immobilized on a gold electrode by self‐assembly. The fabrication process was characterized by scanning electron microscopy, X‐ray spectroscopy analysis and electrochemistry techniques. The results evidenced a stable and sensitivity sensor presenting wide linear detection range (0.65–110 ng/mL). Therefore, it was able to precisely detect MUC1 production patterns in normal (RWPE‐1) and prostate cancer cells (LNCaP and PC3). The biosensor has ability to detect MUC1 in complex samples being an efficient and useful platform for cancer diagnosing in early stages and for physiological applications such as cancer treatment monitoring.
Analysis of response behavior of people in fire incidents where residential fire alarms successfully worked
Authors: Sekizawa Ai , Mizuno Masayuki 
Published: June 2017

SummaryAll residential homes in Japan have been required to install residential fire alarms since 2006. According to a survey by Tokyo Fire Department in 2011, the installation rate of residential fire alarms per household within the jurisdiction of the Tokyo Fire Department is 80.6%. The authors carried out an analysis of reports of cases, where residential fire alarms successfully worked. The information in these real fire incident reports is very useful for us to understand the actual circumstances as well as the behavior of the people involved in and nearby a fire incident. In many cases of successful activation of fire alarms for fires originating in a living room and bedroom, the occupants were likely to be in sleeping in the room of fire origin and did not become aware of the fire alarm, even if it sounded. By contrast, other family members and/or neighbors outside the room of fire origin were more likely to hear the sound and initiated the response activity to the fire incident. This indicates the potential for persons in the room of fire origin at the time of fire to be saved by others nearby because of the activation of residential fire alarms, even if they are sleeping and do not respond by themselves to the alarm sound. Copyright © 2017 John Wiley & Sons, Ltd.
Pivotal role of hMT+ in long‐range disambiguation of interhemispheric bistable surface motion
Authors: Duarte João Valente , Costa Gabriel Nascimento , Martins Ricardo , Castelo‐Branco Miguel 
Published: June 2017

AbstractIt remains an open question whether long‐range disambiguation of ambiguous surface motion can be achieved in early visual cortex or instead in higher level regions, which concerns object/surface segmentation/integration mechanisms. We used a bistable moving stimulus that can be perceived as a pattern comprehending both visual hemi‐fields moving coherently downward or as two widely segregated nonoverlapping component objects (in each visual hemi‐field) moving separately inward. This paradigm requires long‐range integration across the vertical meridian leading to interhemispheric binding. Our fMRI study (n = 30) revealed a close relation between activity in hMT+ and perceptual switches involving interhemispheric segregation/integration of motion signals, crucially under nonlocal conditions where components do not overlap and belong to distinct hemispheres. Higher signal changes were found in hMT+ in response to spatially segregated component (incoherent) percepts than to pattern (coherent) percepts. This did not occur in early visual cortex, unlike apparent motion, which does not entail surface segmentation. We also identified a role for top–down mechanisms in state transitions. Deconvolution analysis of switch‐related changes revealed prefrontal, insula, and cingulate areas, with the right superior parietal lobule (SPL) being particularly involved. We observed that directed influences could emerge either from left or right hMT+ during bistable motion integration/segregation. SPL also exhibited significant directed functional connectivity with hMT+, during perceptual state maintenance (Granger causality analysis). Our results suggest that long‐range interhemispheric binding of ambiguous motion representations mainly reflect bottom–up processes from hMT+ during perceptual state maintenance. In contrast, state transitions maybe influenced by high‐level regions such as the SPL. Hum Brain Mapp 38:4882–4897, 2017. © 2017 Wiley Periodicals, Inc.
fMRI capture of auditory hallucinations: Validation of the two‐steps method
Authors: Leroy Arnaud , Foucher Jack R. , Pins Delphine , Delmaire Christine , Thomas Pierre , Roser Mathilde M. , Lefebvre Stéphanie , Amad Ali , Fovet Thomas , Jaafari Nemat , Jardri Renaud 
Published: June 2017

AbstractOur purpose was to validate a reliable method to capture brain activity concomitant with hallucinatory events, which constitute frequent and disabling experiences in schizophrenia. Capturing hallucinations using functional magnetic resonance imaging (fMRI) remains very challenging. We previously developed a method based on a two‐steps strategy including (1) multivariate data‐driven analysis of per‐hallucinatory fMRI recording and (2) selection of the components of interest based on a post‐fMRI interview. However, two tests still need to be conducted to rule out critical pitfalls of conventional fMRI capture methods before this two‐steps strategy can be adopted in hallucination research: replication of these findings on an independent sample and assessment of the reliability of the hallucination‐related patterns at the subject level. To do so, we recruited a sample of 45 schizophrenia patients suffering from frequent hallucinations, 20 schizophrenia patients without hallucinations and 20 matched healthy volunteers; all participants underwent four different experiments. The main findings are (1) high accuracy in reporting unexpected sensory stimuli in an MRI setting; (2) good detection concordance between hypothesis‐driven and data‐driven analysis methods (as used in the two‐steps strategy) when controlled unexpected sensory stimuli are presented; (3) good agreement of the two‐steps method with the online button‐press approach to capture hallucinatory events; (4) high spatial consistency of hallucinatory‐related networks detected using the two‐steps method on two independent samples. By validating the two‐steps method, we advance toward the possible transfer of such technology to new image‐based therapies for hallucinations. Hum Brain Mapp 38:4966–4979, 2017. © 2017 Wiley Periodicals, Inc.
Factors associated with the pricing of childhood vaccines in the U.S. public sector
Authors: Chen Weiwei , Messonnier Mark , Zhou Fangjun 
Published: June 2017

SummaryVaccine purchase cost has grown substantially over the last few decades. A closer look at vaccine prices reveals that not all vaccines shared the same increasing pattern. Various factors, such as vaccine attributes, competition, and supply shortages, could relate to price changes. In this study, we examined whether a variety of factors influenced the prices of noninfluenza childhood vaccines purchased in the public sector from 1996 to 2014. The association differed among price‐capped vaccines and combination vaccines. There was an increasing time trend in real prices for non‐price‐capped vaccines, which was mostly offset by the effect of market longevity. The effect of competition in lowering prices was more pronounced among non‐price‐capped vaccines when manufacturer and vaccine component fixed effects were excluded. Supply shortage, manufacturer name change, and number of vaccine doses in series showed no effect. The results may help policy makers better understand price behaviors and make more informed decisions in vaccine planning and financing.
Activation of CaMKKβ/AMPKα pathway by 2‐AG in human platelets
Authors: Signorello Maria Grazia , Leoncini Giuliana 
Published: June 2017

AbstractThe objective of this study was to determine whether AMPK is activated by 2‐arachidonoylglycerol (2‐AG) and participates to the cytoskeleton control in human platelets. We found that 2‐AG stimulates the AMPKα activation through a Ca2+/Calmodulin‐dependent pathway as the specific inhibition of the CaMKKβ by STO‐609 inhibits the AMPKα phosphorylation/activation. Moreover, the CaMKKβ/AMPKα pathway activated by 2‐AG is involved in the phosphorylation of cofilin, vasodilator stimulated phosphoprotein (VASP), and myosin light chain (MLCs). These proteins participate to actin cytoskeletal remodelling during aggregation. We found that the phosphorylation/activation inhibition of these proteins is associated with a significant reduction in actin polymerization, aggregation, ATP, and α‐granule secretion. Finally, AMPKα activation, Cofilin, VASP, and MLCs phosphorylation are significantly reduced by SR141716, the specific inhibitor of type 1 cannabinoid (CB1) receptor, suggesting that the CB1 receptor is involved in the 2‐AG effect. In conclusion, we have shown that the CaMKKβ/AMPKα pathway is activated by 2‐AG in human platelets and controls the phosphorylation of key proteins involved in actin polymerization and aggregation.
A comparison of temporal variability of observed and model‐based pan evaporation over Uruguay (1973–2014)
Authors: Vicente‐Serrano Sergio M. , Bidegain Mario , Tomas‐Burguera Miquel , Dominguez‐Castro Fernando , El Kenawy Ahmed , McVicar Tim R. , Azorin‐Molina Cesar , López‐Moreno Juan I. , Nieto Raquel , Gimeno Luis , Giménez Agustín 
Published: June 2017

ABSTRACTThis study analyses variability and trends of atmospheric evaporative demand (AED) across Uruguay in the past four decades. Changes were assessed using pan evaporation measurements from 10 meteorological stations and compared to PenPan model calculations, which is a physically based model that employs meteorological data as input. Results demonstrate a high agreement between the observed AED and those estimated from the PenPan model. Both observations and model estimations agree on a high interannual variability in AED, though being statistically insignificant (p > 0.05) at seasonal and annual scales. Given that AED shows high sensitivity to changes in relative humidity and sunshine duration, as a surrogate of solar radiation, the lack of significant trends in the AED observations and estimations over Uruguay can be linked to the insignificant trend found for these climate variables for the period from 1973 to 2014. This is the first study that reports Pan evaporation trends for this part of the world, helping to infill gaps for mid‐latitude Southern Hemisphere areas, which are poorly represented in Pan evaporation trends.
Physical activity participation and the association with work‐related upper quadrant disorders (WRUQDs): A systematic review
Authors: Mansfield Michael , Thacker Michael , Smith Toby 
Published: June 2017

AbstractBackgroundWorkers in various occupations often report work‐related upper quadrant disorders (WRUQDs). Research has shown that associative factors for WRUQDs include psychosocial and environmental elements, gender and physical activity levels. To date, no review has investigated whether physical activity participation is associated with and/or predicts the development of WRUQDs, so the present study set out to determine this.MethodsA systematic review was conducted including searches of PubMed (MEDLINE), EMBASE and CINAHL from inception to 31 March 2017. Quantitative studies, including any outcome measure of physical activity participation and its association with and/or prediction of WRUQDs, were included. One reviewer conducted the search and two reviewers independently assessed eligibility and completed methodological quality assessment using a modified Downs and Black checklist. Data were analysed narratively.ResultsEight studies were eligible for inclusion in the final review. The quality of these ranged from moderate to high quality. Three studies reported no statistical difference between physical activity participation and the risk of developing WRUQD. Three studies reported a negative and one study a positive association between physical activity participation and WRUQDs. One study reported that little or no physical exercise participation was a risk factor for WRUQD.ConclusionsThere is limited evidence for a negative association between physical activity participation and the development of WRUQDs. However, this was not a consistent finding across all studies included. Further research is indicated in standardizing diagnostic criteria and the measurement of physical activity participation in this patient population.
Stress and strain fields for overdamped slug tests in aquifer materials, and resulting conservation equation
Authors: Chapuis Robert P. 
Published: June 2017

SummaryTwo theories may be used to analyze overdamped variable‐head (slug) tests in aquifer materials. The first theory assumes that the solid matrix strain has a negligible influence. The second theory takes into account some elastic and immediate strain. Something is wrong with these theories because they yield different hydraulic conductivity values. This paper explains what is wrong after establishing the strain‐stress elastic equations for a slug test in 2 ideal conditions: plane strain and spherical symmetry. The equations show that the radial contraction (or elongation) and tangential elongation (or contraction) yield a null volumetric strain. As a result, the conservation is described by the Laplace equation, which is used by the first theory. This first theory is the only one to yield correct solutions. The diffusion equation, with storativity, which is used by the second theory, is physically ill founded for slug tests in aquifers. This new proof scientifically confirms previously raised doubts and experimental proofs that the second theory is ill founded.
X‐ray photoelectron study of oxides formed on Ni metal and Ni‐Cr alloy surfaces under electrochemical control at 25 °C and 150 °C
Authors: Payne B. P. , Keech P. G. , McIntyre N. S. 
Published: June 2017

AbstractThe oxide chemical composition on metallic Ni and NiCr alloy electrodes has been studied for changes in simulated reactor coolant solution chemistry, through a range of oxidizing potentials and pH settings at 25 °C and 150 °C. Even under strongly reducing conditions, the Ni surface has a 2‐nm layer of oxide and hydroxide from which further oxides form, depending on the subsequent oxidative step. For basic (normal operating) pH conditions and under oxidation potentials near 0 volts (vs. SCE), a predominantly Ni(OH)2 layer is formed that appears to remain relatively stable up to at least 48 hours of oxidation at 150 °C. For the NiCr alloy, similar stability is imparted by a thin film of Cr(OH)3/ Cr2O3 and Ni(OH)2./NiO. Under milder oxidizing (but still basic) conditions, the surface is stabilized by a thin film that is mostly Ni(OH)2/NiO. Under neutral solution conditions, the same oxide/ hydroxide films do not seem to be as effective in stabilizing the surface. Copyright © 2017 John Wiley & Sons, Ltd.
Gentherapie zur Behandlung von Netzhauterkrankungen
Authors: Ochakovski G. Alex , Bartz-Schmidt Karl Ulrich , Fischer M. Dominik 
Published: June 2017

Zusammenfassung
Eine Reihe von Netzhauterkrankungen hat bekannte genetische Ursachen, die prinzipiell durch Gentherapie behandelt werden können. Diese Übersicht stellt das Prinzip und die Besonderheiten der okulären Gentherapie dar, fasst den aktuellen Stand der Forschung bis hin zur klinischen Anwendung zusammen und gibt einen Ausblick auf aktuelle Entwicklungen der Gentherapie am Auge.
How Evacuees Obtained Health Care Information After the Great East Japan Earthquake: A Qualitative Interview Study
Authors: Ota Haruka , Miyazaki Kikuko , Nakayama Takeo 
Published: June 2017

AbstractObjectiveTo explore how evacuees obtained health care information at their evacuation destinations after the Great East Japan Earthquake.MethodsWe conducted semi-structured interviews of 11 evacuees who moved to City A in Kyoto Prefecture following the Great East Japan Earthquake. The interviews explored how the evacuees obtained health care information, including the main factors of influence. The interviews were transcribed and analyzed to identify trends by using the constant comparative method.ResultsFour categories emerged from 6 concepts. Mother-children evacuees and family evacuees tended to obtain health care information in different ways. Family evacuees had moved as a family unit and had obtained their health care information from local neighbors. Mother-children evacuees were mothers who had moved with their children, leaving behind other family members. These evacuees tended to obtain information from other mother-children evacuees. At the time of evacuation, we found 2 factors, emotions and systems, influencing how mother-children evacuees obtained health care information.ConclusionsWe found 2 different ways of obtaining health care information among mother-children evacuees and other evacuees. At the time of evacuation, 2 factors, emotions and systems, influenced how mother-children evacuees obtained health care information. Community-building support should be a priority from an early stage after a disaster for health care management. (Disaster Med Public Health Preparedness. 2017;11:729–734)
Prussian Palimpsests: Historic Architecture and Urban Spaces in East Germany, 1945–1961
Authors: Colla Marcus 
Published: June 2017

AbstractThis article considers the fate of Prussian buildings and memorials in East Germany between 1945 and 1961. Analyzing a number of case studies from Berlin and Potsdam, it places the treatment of these structures within the broader contours of history management practices. Although this era was characterized by a strong anti-Prussian sentiment in the GDR's historical discourse, it also witnessed a complex interaction between the SED and its historical inheritance. This interaction often influenced decisions about the fate of Prussian structures in the GDR as much as any animosity toward Prussia as a historical entity did.
Measurement of KM Projects: a Practical Guide for Librarians
Authors: Russell Hélène 
Published: June 2017

AbstractThis article written by Hélène Russell aims to look at the measurement of Knowledge projects and activities in a simple, practical way, with the aim of helping busy law firm librarians understand whether their various Knowledge Management (KM) projects and activities are having a positive effect and are value for money in a general sense. Be forewarned: the benefits of KM are often intangible and the way that KM affects tangibles can be complex, so measurement is difficult. However, that does not mean that you cannot approximate an answer which is useful for informing business decisions.
MicroRNA-29a induces loss of 5-hydroxymethylcytosine and promotes metastasis of hepatocellular carcinoma through a TET–SOCS1–MMP9 signaling axis
Authors: Chen Qing , Yin Dan , Zhang Yong , Yu Lei , Li Xue-Dong , Zhou Zheng-Jun , Zhou Shao-Lai , Gao Dong-Mei , Hu Jie , Jin Cheng , Wang Zheng , Shi Ying-Hong , Cao Ya , Fan Jia , Dai Zhi , Zhou Jian 
Published: June 2017

AbstractTen eleven translocation (TET) enzymes convert 5-methylcytosine (5-mC) to 5-hydroxy-methylcytosine (5-hmC) and have crucial roles in biological and pathological processes by mediating DNA demethylation, however, the functional role of this epigenetic mark and the related enzymes in hepatocellular carcinoma (HCC) progression remains unknown. Here, we demonstrated that TET-family enzymes downregulation was one likely mechanism underlying 5-hmC loss in HCC. We found that miR-29a overexpression increased DNA methylation of suppressor of cytokine signaling 1 (SOCS1) promoter was associated with HCC metastasis in vitro and in vivo. Furthermore, miR-29a silenced anti-metastatic SOCS1 through direct TET-family targeting, resulting in SOCS1 promoter demethylation inhibition. Chromatin immunoprecipitation analyses confirmed that TET1 regulated SOCS1 expression through binding to the promoter region of SOCS1. Finally, miR-29a overexpression correlated with poor clinical outcomes and TET–SOCS1–matrix metalloproteinase (MMP) 9 axis silencing in HCC patients. In conclusion, our findings demonstrate that 5-hmC loss is an epigenetic hallmark of HCC, and miR-29a is an important epigenetic modifier, promoting HCC metastasis through TET–SOCS1–MMP9 axis silencing. The results offer a new strategy for epigenetic cancer therapy.
Virtual Screening, pharmacophore development and structure based similarity search to identify inhibitors against IdeR, a transcription factor of Mycobacterium tuberculosis
Authors: Rohilla Akshay , Khare Garima , Tyagi Anil K. 
Published: June 2017

AbstractideR, an essential gene ofMycobacterium tuberculosis, is an attractive drug target as its conditional knockout displayed attenuated growth phenotypein vitroandin vivo. To the best of our knowledge, no inhibitors of IdeR are identified. We carried out virtual screening of NCI database against the IdeR DNA binding domain followed by inhibition studies using EMSA. Nine compounds exhibited potent inhibition with NSC 281033 (I-20) and NSC 12453 (I-42) exhibiting IC50values of 2 µg/ml and 1 µg/ml, respectively. We then attempted to optimize the leads firstly by structure based similarity search resulting in a class of inhibitors based on I-42 containing benzene sulfonic acid, 4-hydroxy-3-[(2-hydroxy-1-naphthalenyl) azo] scaffold with 4 molecules exhibiting IC50 ≤ 10 µg/ml. Secondly, optimization included development of energy based pharmacophore and screening of ZINC database followed by docking studies, yielding a molecule with IC50of 60 µg/ml. More importantly, a five-point pharmacophore model provided insight into the features essential for IdeR inhibition. Five molecules with promising IC50values also inhibitedM. tuberculosisgrowth in broth culture with MIC90ranging from 17.5 µg/ml to 100 µg/ml and negligible cytotoxicity in various cell lines. We believe our work opens up avenues for further optimization studies.