bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Potential Role of Sophora alopecuroides L. in Inflammation of Bovine Mammary Epithelial Cells Induced by Lipoteichoic Acid Based
on Network Pharmacology and Experimental Validation
Authors: Yuan Ziwen , Li Fang , Zhang Wenfei , Wei Yanming , Hua Yongli 
Published: September 2024

Aim:
This study aimed to investigate the anti-inflammatory effect and mechanism of
Sophora alopecuroides L. (KDZ) on lipoteichoic acid (LTA)-induced inflammation in Bovine
Mammary Epithelial Cells (BMEC).

Method:
The KDZ active ingredient database was established by using ultra-high-performance
liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) to detect
the chemical components of KDZ and combine it with the TCMSP database. Furthermore,
potential targets of KDZ active ingredients were collected through the UniProt database, and
mastitis-related targets were screened through the OMIM, Genecard, and DisGeNET databases.
Furthermore, common targets were identified between ingredient targets and disease targets, and
protein-protein interaction analysis was performed on them using the STRING platform. Furthermore,
the protein interaction network was constructed using Cytoscape software. Core targets
were screened through network topology analysis. On this basis, GO and KEGG enrichment
analyses were performed on the common target, and molecular simulation docking analysis was
conducted on the main active ingredients and core targets. Finally, the accuracy of the network
analysis results was validated using in vitro cell experiments.

Result:
The results of UPLC-QTOF-MS detection and network pharmacology analysis showed
that KDZ could intervene in signaling pathways, such as the IL-17 signaling pathway, TNF signaling
pathway, MAPK signaling pathway, etc., by acting on 80 common targets through 15 potential
active ingredients, thereby regulating biological processes, such as positive regulation of
peptidyl serine physiology, apoptotic process, and inflammatory response, to treat mastitis. Besides,
molecular simulation docking analysis also showed that the main active ingredients in
KDZ, such as quercetin, matrine, calycosin, etc., can form stable bindings with 11 core targets
(TNF-α, IL-6, IL-1β, etc.) through hydrogen bonding. Further in vitro validation experiments
confirmed that KDZ intervention could inhibit the IL-17 signaling pathway by inhibiting the expression
of GSK3β and subsequently inhibiting the production of downstream inflammatory cytokines
IL-8, IL-6, IL-1β, and TNF-α, thereby alleviating LTA-induced BMEC inflammatory
damage.

Conclusion:
KDZ can alleviate LTA-induced BMEC inflammatory damage by inhibiting the IL-
17 signaling pathway. This study can provide a scientific basis for the clinical application of
KDZ and lay the foundation for the development of new therapeutic drugs for mastitis.
A Comprehensive Review on Nephrolithiasis: Etiology Recent Advances and Clinical Trials
Authors: Pal Karan , Verma Sushma , Agarwal Chhaya , Sharma Deep Shikha 
Published: September 2024

Abstract:
Kidney stone disease, or nephrolithiasis, is a common condition with high morbidity
that affects people all over the world. It is important to comprehend the etiology and contemporary
developments in its management to enhance patient results. In this study, we describe a thorough
analysis of nephrolithiasis, with particular attention to its etiology, current developments in
treatment modalities, and ongoing clinical studies by utilizing electronic databases. A thorough
search of the literature was carried out to find pertinent papers published through 2024 and the genesis
of nephrolithiasis, new treatment developments, and ongoing clinical trials. The review clarifies
the complex interplay between dietary variables, metabolic disorders, and genetic susceptibility
that leads to nephrolithiasis. The most recent developments in treatment modalities, such as minimally
invasive operations and medication therapies, are examined. Furthermore, ongoing clinical
trials examining new treatments and preventative measures are emphasized. A multidisciplinary
approach is necessary for the optimal care of nephrolithiasis because it is a complex condition influenced
by a variety of factors. While ongoing clinical trials hold promise for additional innovation
in nephrolithiasis therapy and prevention, recent therapeutic developments offer promising
pathways for enhanced patient care. Addressing the difficulties brought on by this common ailment
requires cooperation and ongoing study.
National Trends in the Prevalence of Unmet Health Care and Dental Care Needs During the COVID-19 Pandemic: Longitudinal Study in South Korea, 2009-2022
Authors: Kim Yeji , Kim Soeun , Lee Somin , Park Jaeyu , Koyanagi Ai , Smith Lee , Kim Min Seo , Fond Guillaume , Boyer Laurent , López Sánchez Guillermo Felipe , Dragioti Elena , Kim Hyeon Jin , Lee Hayeon , Son Yejun , Kim Minji , Kim Sunyoung , Yon Dong Keon 
Published: September 2024

Background
Although previous studies have investigated trends in unmet health care and dental care needs, most have focused on specific groups, such as patients with chronic conditions and older adults, and have been limited by smaller data sets.

Objective
This study aims to investigate the trends and relative risk factors for unmet health care and dental care needs, as well as the impact of the COVID-19 pandemic on these needs.

Methods
We assessed unmet health care and dental care needs from 2009 to 2022 using data from the Korea Community Health Survey (KCHS). Our analysis included responses from 2,750,212 individuals. Unmet health care or dental care needs were defined as instances of not receiving medical or dental services deemed necessary by experts or desired by patients.

Results
From 2009 to 2022, the study included 2,700,705 individuals (1,229,671 men, 45.53%; 673,780, 24.95%, aged 19-39 years). Unmet health care needs decreased before the COVID-19 pandemic; however, during the pandemic, there was a noticeable increase (βdiff 0.10, 95% CI 0.09-0.11). Unmet dental care needs declined before the pandemic and continued to decrease during the pandemic (βdiff 0.23, 95% CI 0.22-0.24). Overall, the prevalence of unmet dental care needs was significantly higher than that for unmet health care needs. While the prevalence of unmet health care needs generally decreased over time, the β difference during the pandemic increased compared with prepandemic values.

Conclusions
Our study is the first to analyze national unmet health care and dental care needs in South Korea using nationally representative, long-term, and large-scale data from the KCHS. We found that while unmet health care needs decreased during COVID-19, the decline was slower compared with previous periods. This suggests a need for more targeted interventions to prevent unmet health care and dental care needs.
Assessing the Evidence for Nonobstetric Risk Factors for Deformational Plagiocephaly: Systematic Review and Meta-Analysis (Preprint)
Authors: Hillyar Christopher Robert Timothy , Bishop Natalie , Nibber Anjan , Bell-Davies Frances Jean , Ong Juling 
Published: September 2024

BACKGROUND

Plagiocephaly is defined as an asymmetrical distortion of the skull, resulting in an oblique trapezoid or parallelogram head shape. Deformational plagiocephaly (DP) is caused by forces acting on one side of the back of the head, distorting normal skull symmetry.

OBJECTIVE

The aims of this systematic review and meta-analysis were to critically assess the evidence for nonobstetric risk factors for DP and to make evidence-based recommendations for reducing the prevalence of DP.

METHODS

The selection criterion was studies reporting risk factors for DP. Case reviews, case series, expert opinions, and systematic reviews were excluded. PubMed and Web of Science were searched from August 21, 2010, to August 21, 2022. Publication bias was assessed using funnel plots. Meta-analyses were presented using forest plots.

RESULTS

A total of 19 studies (cohort studies: n=13, 68%; case-control studies: n=5, 26%; and cross-sectional studies: n=1, 5%) with a total of 14,808 participants were included. Of the 43 investigated potential nonobstetric factors, 16 (37%) were associated with DP. Of these 16 factors, 12 (75%) had odds ratios (ORs) with 95% CIs not crossing 1: insufficient vitamin D intake (OR 7.15, 95% CI 3.77-13.54), head position preference (OR 4.75, 95% CI 3.36-6.73), bottle-only feeding (OR 4.65, 95% CI 2.70-8.00), reduced tummy time (OR 3.51, 95% CI 1.71-7.21), sleeping position (OR 3.12, 95% CI 2.21-4.39), fewer motor milestones reached by the age of 6 months (OR 2.56, 95% CI 1.66-3.96), obesity (OR 2.45, 95% CI 1.02-5.90), maternal education level (OR 1.66, 95% CI 1.17-2.37), male sex (OR 1.51, 95% CI 1.07-2.12), formula feeding (OR 1.51, 95% CI 1.00-2.27), head circumference (OR 1.22, 95% CI 1.06-1.40), and mechanical ventilation (OR 1.10, 95% CI 1.00-1.14). No evidence of publication bias was detected.

CONCLUSIONS

This study provides a comprehensive assessment of the nonobstetric factors associated with DP and presents 11 evidence-based recommendations for reducing its prevalence. The primary limitation is that only publication bias was assessed.

CLINICALTRIAL

PROSPERO CRD42020204979; https://www.crd.york.ac.uk/prospero/display_record.php? ID=CRD42020204979
Rancang Bangun Sistem Informasi Akuntansi Berbasis Web P- Toko Sparepart Sepeda Motor
Authors: Selaningrum Ika Fitria 
Published: September 2024

Penelitian ini bertujuan untuk merancang Sistem Informasi Akuntansi (SIA) untuk pelaporan keuangan Toko Sparepart Sepeda Motor. Objek penelitian ini adalah Toko Lancar Motor 2, di kota Bekasi. Penelitian ini dibatasi pada luaran Sistem Informasi Akuntansi yaitu laporan arus kas. Unit analisis adalah bukti transaksi berupa bukti penerimaan dan pengeluaran kas dari data pemilik toko. Pada penelitian ini dirancang sistem informasi akuntansi laporan keuangan berbasis web pada Toko Lancar Motor 2 dengan menggunakan perancangan sistem diagram UML. Pada tahap ini, tiga jenis diagram UML akan digunakan yaitu use case diagram, activity diagram, dan sequence diagram. Lalu dilakukan perancangan antarmuka pengguna yang intuitif, user-friendly, dan memudahkan pengguna dengan aplikasi desain Figma. Hasil dari penelitian ini adalah rancangan sistem informasi akuntansi yang mengatasi masalah-masalah yang diidentifikasi sebelumnya. Sistem ini diharapkan dapat mempercepat dan memudahkan proses pengelolaan laporan keuangan serta menghasilkan data yang akurat dan up-to-date bagi Toko Lancar Motor 2.
<i>Spongia officinalis</i> -Associated <i>Pseudomonas fluorescens</i> as a Reservoir of Bioactive Compounds: A Novel Source of Natural Anticancer Compounds
Authors: Subbiah Usharani , Dinakarkumar Yuvaraj , Jeyaraman Madhusudhanan 
Published: September 2024

Marine sponges are an important source of chemical variety and a repository of biodiversity. In this study, the microbial communities found in the marine sponge Spongia officinalis that was taken from the Kanyakumari coast in India were explored. We identified, characterized, and evaluated the bioactive potential of the sponge-associated bacteria. A total of 12 bacterial isolates were obtained, primarily consisting of gram-positive rods and some gram-negative rods and cocci. These bacterial isolates showed a variety of bioactive substances when their secondary metabolites were extracted, including phenols, flavonoids, alkaloids, saponins, terpenoids, and steroids. These chemical compounds are well-known for their numerous biological activity and health benefits. The antioxidant and anticancer effects of these metabolites were also investigated. Isolate 6 showed significant antioxidant activity, suggesting it may be able to treat cancer. With an IC50 value of 55.32 g/ml, this isolate also displayed impressive anticancer activity against HeLa cells. The screened isolate was identified as Pseudomonas fluorescens strain ATCC 13525 using 16S rRNA sequencing. This discovery emphasizes the importance of bacteria associated with marine sponges as a source of bioactive compounds with medicinal potential. The conclusion of this research highlights the diverse microbial communities found in marine sponges and their potential for use in biotechnology and medication development. Pseudomonas fluorescens was found to be a prolific generator of bioactive byproducts, including strong antioxidants and anticancer agents, which emphasizes the significance of additional marine resource exploitation for pharmacologically relevant chemicals.
Implementation of a midline catheter service in a regional setting
Authors: Jones Paul 
Published: September 2024

Abstract

Introduction:
Midline catheters have been reported to be an effective and safe means of providing patients with intravenous access within the hospital and community setting. With minimal experience in the introduction of a midline service across the local health network, a regional hospital pursued this task. This observational study assesses the provision of a safe clinical framework for midline insertion, and the improvement of patient care and experiences by avoiding treatment interruptions and unnecessary cannulation attempts from failed traditional peripheral vascular access devices.

Methods:
From the introduction of the midline service in June 2018, outcome measures of all patients who received a midline over the following two-year period were documented including rate of line success, complication rates, dwell time, and the number of insertion attempts.

Results:
The midline service provided 207 lines over a two-year period with a total dwell time of 1,585 days. Project goals were achieved with 85% (Aim ≥ 85%) of all lines completing treatment prior to removal. First attempt insertion was 86% (Aim ≥ 80%) with a maximum insertion attempt of two. Rates of line-related complications were less than 8%, with five documented cases of phlebitis (2.5%) and one deep vein thrombosis with no infections documented.

Conclusion:
Despite limited resources, a successful midline service was introduced. Future expansion will see an increase in insertor numbers providing improved access to the service.
CAT Study: Pediatric Catheter-Associated Thrombosis: A Retrospective Electronic Record Review
Authors: Rejtar Marketa , McGrath Ellen , Rabe Megan , Ranstrom Lee , Sutcliffe Abigail , Rogers Laura , Morrison Pamela , Berbert Laura , Lajoie Debra , Jaksic Tom 
Published: September 2024

Highlights
CAT is a significant problem in pediatric patients with CVCs and other risk factors. CAT was found in 4% of the sample with estimated 0.23 events per 1,000 CVC days. Incidence of CAT was lower than anticipated but consistent with published evidence. Median LOS was substantial in the CAT group suggesting increased disease burden. Specific clinical modifiers and CVC factors were more common in the CAT group. Findings provide valuable foundation for future CAT research and risk models. Clinicians and researchers should collaborate to reduce CAT incidence.

Abstract

Background:
Catheter-associated thrombosis (CAT) is a serious condition, especially among pediatric surgical patients. This study describes the CAT incidence rate and clinical, demographic, and central venous catheter (CVC)-specific risk factors that may be associated with CAT, for a cohort of pediatric surgical patients.

Methods:
An electronic record review of 124 pediatric surgical patients with indwelling CVCs receiving parenteral nutrition (PN) cared for in a single pediatric hospital between 2016 and 2018 was performed.

Results:
Of the 297 CVCs, 4% of patients (n = 5) developed CAT, resulting in an estimated incidence rate of 0.23 events per 1,000 CVC days (95% confidence interval 0.15–0.31). Patients diagnosed with CAT had a higher burden of anemia, blood product administration, chronic lung disease, congenital heart disease, sepsis, prolonged mechanical ventilation, extracorporeal membrane oxygenation use, increased surgical complexity, and longer hospital stays. They also had a higher frequency of peripherally inserted central catheters, small caliber size CVCs, double lumen CVCs, extended PN and lipid course, lack of ethanol prophylaxis, higher rates of intravenous antibiotics, lower rates of treatment-dose heparin, and prolonged CVC duration.

Conclusion:
The incidence of CAT in this study was consistent with published rates for hospitalized pediatric patients with CVCs. The study provides additional foundational evidence about clinical, demographic, and CVC-specific risk factors associated with CAT in pediatric surgical patients with CVCs. It can help guide future research and collaborative efforts to develop risk assessment and other preventative strategies to reduce CAT incidence and improve patient care outcomes.
Endovascular Reconstruction of Type 3 Central Venous Obstruction: A Case Report
Authors: Bazzocchi Maria Vittoria , Andreone Andrea , Multinu Roberta , Paladini Ilaria , Cinque Antonio De , Capurri Giulia , Epifani Enrico 
Published: September 2024

Highlights

Abstract
Superior vena cava (SVC) syndrome with central thoracic vein occlusion associated with the use of intravascular devices is increasing and involves younger patients.
Hemodialysis patients are at higher risk for central vein occlusion and symptomatic SVC syndrome. It is imperative to preserve venous access, particularly for younger patients who will rely on dialysis for an extended duration. Endovascular venous reconstruction is the recommended treatment but there are not standardized guidelines about the type of stent and technique.
In the present case report the primary objective was to resolve the central vein occlusion and maintain vein patency through double barrel and Y technique together, employing bare metal and covered stents.
Standards of Care for Peripheral Intravenous Catheters: Evidence-Based Expert Consensus
Authors: Thompson Judy , Steinheiser Marlene M. , Hotchkiss J. Blake , Davis James , DeVries Michelle , Frate Katie , Helm Robert , Jungkans Chris W. , Kakani Swapna , Lau Sean , Lindell Karen , Landrum Kristen McNiff , McQuillan Karen A. , Shannon DJ , Wuerz Lorelle , Pitts Stephanie 
Published: September 2024

Highlights

Abstract

Background:
The insertion of a peripheral intravenous catheter (PIVC) is the most commonly performed invasive procedure in healthcare. Despite its frequency in placement in hospitalized patients, PIVCs are generally perceived as being safe; however, the prevalence of failure ranges from 35%-50%. Additionally, complications are common and often deemed “acceptable” by clinicians. Healthcare provider and clinician foundational knowledge and competency is lacking nationally. Considering the mere volume of PIVCs placed, the failure and complication rates, the human impact is significant.

Methods:
The Association for Vascular Access (AVA) has led a collaborative effort with representatives from the Infusion Nurses Society (INS), the American Association of Critical Care Nurses (AACN), ECRI, and content experts representing nursing vascular access, infusion therapy, infection prevention, critical care, pediatrics, healthcare leadership, a physician, and a patient representative. Our aim is to provide concise guidance that will enhance and standardize practices related to peripheral intravenous catheters (PIVC). By consolidating current standards of practice into a comprehensive document, our framework seeks to advance the quality of care and improve patient safety.

Results:
This document has undergone meticulous scrutiny to ensure its quality; including incorporation of current standards, methodology for consensus from the expert panel, and input received from public comments.

Conclusions:
We anticipate that this work will have a significant impact on healthcare professionals, policymakers, and, most importantly, patients’ experiences by the promotion of consistent, high-quality treatment, safety, and comfort for patients receiving a PIVC.
Vitalii Ivanovich Startsev, an Outstanding Researcher of the Political History of Twentieth-Century Russia and the Russian Revolution of 1917 Review of Politicheskaya istoriya Rossii XX veka: k 90-letiyu professora Vitaliya Ivanovicha Startseva: Sbornik vospominanii i nauchnykh statei [Political history of twentieth-century Russia: On the 90thanniversary of Professor Vitalii I. Startsev: A collection of memoirs and scientific articles], edited by A.B. Nikolaev et al. (St Petersburg: Asterion, 2023)
Authors: Руднева С.Е. 
Published: September 2024

Рецензент анализирует сборник научных статей «Политическая история России XX века», изданный по материалам международной научной конференции, посвященной 90-летию профессора Виталия Иванович Старцева, которую 14–15 сентября 2021 г. провела кафедра русской истории (XIX–XXI вв.) Института истории и социальных наук РГПУ им. А.И. Герцена. В рецензии рассматриваются воспоминания о В.И. Старцеве и ключевые статьи сборника, затрагивающие проблемы, находившиеся в сфере его интересов. Отмечено значение рецензируемого сборника с историографической и источниковедческой точек зрения. Подчеркнуто, что опубликованные в сборнике статьи помогают оценить личный вклад выдающегося историка В.И. Старцева в изучение проблем политической истории России XX века и российской революции 1917 г., вносят новизну в трактовку событий революционного периода, способствуют переосмыслению некоторых прежних историографических положений. Кроме того, во многих статьях сборника впервые вводятся в научный оборот новые источники по различным аспектам политической истории России начала XX века.
The reviewer analyzes a collection of scientific articles Political History of Twentieth-Century Russia. The collection contains the proceedings of the international scientific conference dedicated to the 90th anniversary of Professor Vitalii I. Startsev, which was held on September 14–15, 2021 by the Department of Russian History (19th–21stCenturies) of the Institute of History and Social Sciences of the Herzen State Pedagogical University. The reviewer considers the recollections of V. Startsev and the key articles in the collection on problems that were in the focus of his attention and notes the importance of the collection under review from historiographical and source-study points of view. It is emphasized that the articles included in the collection help to evaluate the contribution of outstanding historian V. Startsev to the study of the problems of political history of twentieth-century Russia and the Russian revolution of 1917, introduce novelty into the interpretation of the events of the revolutionary period, and contribute to the rethinking of some previous historiographical provisions. In addition, in many articles of the collection, new sources on various aspects of the political history of Russia of the early 20thcentury are introduced into scientific circulation for the first time.