bluuebunny/crossref_metadata_2025_split huggingface dataset:
Locally indistinguishable orthogonal product bases in arbitrary bipartite quantum system
Authors: Xu Guang-Bao , Yang Ying-Hui , Wen Qiao-Yan , Qin Su-Juan , Gao Fei 
Published: August 2016

AbstractAs we know, unextendible product basis (UPB) is an incomplete basis whose members cannot be perfectly distinguished by local operations and classical communication. However, very little is known about those incomplete and locally indistinguishable product bases that are not UPBs. In this paper, we first construct a series of orthogonal product bases that are completable but not locally distinguishable in a general m ⊗ n (m ≥ 3 and n ≥ 3) quantum system. In particular, we give so far the smallest number of locally indistinguishable states of a completable orthogonal product basis in arbitrary quantum systems. Furthermore, we construct a series of small and locally indistinguishable orthogonal product bases in m ⊗ n (m ≥ 3 and n ≥ 3). All the results lead to a better understanding of the structures of locally indistinguishable product bases in arbitrary bipartite quantum system.
Stochastic anomaly of methylome but persistent SRY hypermethylation in disorder of sex development in canine somatic cell nuclear transfer
Authors: Jeong Young-Hee , Lu Hanlin , Park Chi-Hun , Li Meiyan , Luo Huijuan , Kim Joung Joo , Liu Siyang , Ko Kyeong Hee , Huang Shujia , Hwang In Sung , Kang Mi Na , Gong Desheng , Park Kang Bae , Choi Eun Ji , Park Jung Hyun , Jeong Yeon Woo , Moon Changjong , Hyun Sang-Hwan , Kim Nam Hyung , Jeung Eui-Bae , Yang Huanming , Hwang Woo Suk , Gao Fei 
Published: August 2016

AbstractSomatic cell nuclear transfer (SCNT) provides an excellent model for studying epigenomic reprogramming during mammalian development. We mapped the whole genome and whole methylome for potential anomalies of mutations or epimutations in SCNT-generated dogs with XY chromosomal sex but complete gonadal dysgenesis, which is classified as 78, XY disorder of sex development (DSD). Whole genome sequencing revealed no potential genomic variations that could explain the pathogenesis of DSD. However, extensive but stochastic anomalies of genome-wide DNA methylation were discovered in these SCNT DSD dogs. Persistent abnormal hypermethylation of the SRY gene was observed together with its down-regulated mRNA and protein expression. Failure of SRY expression due to hypermethylation was further correlated with silencing of a serial of testis determining genes, including SOX9, SF1, SOX8, AMH and DMRT1 in an early embryonic development stage at E34 in the XYDSD gonad, and high activation of the female specific genes, including FOXL2, RSPO1, CYP19A1, WNT4, ERα and ERβ, after one postnatal year in the ovotestis. Our results demonstrate that incomplete demethylation on the SRY gene is the driving cause of XYDSD in these XY DSD dogs, indicating a central role of epigenetic regulation in sex determination.
Polydiacetylenyl β-cyclodextrin based smart vesicles for colorimetric assay of arginine and lysine
Authors: Cho Eunae , Kim Hwanhee , Choi Youngjin , Paik Seung R. , Jung Seunho 
Published: August 2016

AbstractSelective visualization of arginine and lysine has been explored among 20 amino acids using the hybrid conjugate of β-cyclodextrin (β-CD) and polydiacetylene (PDA). The mono pentacosa-10,12-diynyl aminomethyl group was successfully coupled to either the primary or the secondary face of β-CD, where mono-6-amino-6-deoxy-β-CD or mono-3-amino-3-deoxy-β-CD reacted with the N-hydroxysuccinimide ester of 10,12-pentacosadiynoic acid. In this combinatorial system, the cylindrical β-cyclodextrin functions as a channel for the introduction of the cationic amino acids to the artificial membrane. The membrane perturbation and aggregation by the target amino acids could be exclusively visualized as a blue to red color change based on the responsive polydiacetylene domain. These interesting findings demonstrated that the developed β-CD conjugated PDA system may offer a new method of cell-penetrating mechanism, a promising vector system, as well as impact the production industry of arginine or lysine.
The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise
Authors: Ogasawara Riki , Fujita Satoshi , Hornberger Troy A. , Kitaoka Yu , Makanae Yuhei , Nakazato Koichi , Naokata Ishii 
Published: August 2016

AbstractResistance exercise (RE) activates signalling by the mammalian target of rapamycin (mTOR) and it has been suggested that rapamycin-sensitive mTOR signalling controls RE-induced changes in protein synthesis, ribosome biogenesis, autophagy and the expression of peroxisome proliferator gamma coactivator 1 alpha (PGC-1α). However, direct evidence to support the aforementioned relationships is lacking. Therefore, in this study, we investigated the role of rapamycin-sensitive mTOR in the RE-induced activation of muscle protein synthesis, ribosome biogenesis, PGC-1α expression and hypertrophy. The results indicated that the inhibition of rapamycin-sensitive mTOR could prevent the induction of ribosome biogenesis by RE, but it only partially inhibited the activation of muscle protein synthesis. Likewise, the inhibition of rapamycin-sensitive mTOR only partially blocked the hypertrophic effects of chronic RE. Furthermore, both acute and chronic RE promoted an increase in PGC-1α expression and these alterations were not affected by the inhibition of rapamycin-sensitive mTOR. Combined, the results from this study not only establish that rapamycin-sensitive mTOR plays an important role in the RE-induced activation of protein synthesis and the induction of hypertrophy, but they also demonstrate that additional (rapamycin-sensitive mTOR-independent) mechanisms contribute to these fundamentally important events.
Helicity-dependent photocurrent induced by the in-plane transverse electric current in an InAs quantum well
Authors: Li J. B. , Wu X. G. , Wang G. W. , Xu Y. Q. , Niu Z. C. , Zhang X. H. 
Published: August 2016

AbstractWe report the observation of a new type of helicity-dependent photocurrent induced by an in-plane transverse direct electric current in an InAs quantum well. The amplitude of the photocurrent depends linearly on the transverse current. Moreover, the observed incident azimuth-angle dependence of this photocurrent is different from that induced by the circular photogalvanic effect. This new photocurrent appears as a result of an asymmetrical carrier distribution in both the conduction and valence bands induced by the transverse current. The photoexcited carrier density created by interband transition processes is thus modulated and leads to the observed new azimuth-angle dependence. The observed efficient generation of the helicity-dependent photocurrent offers an effective approach to manipulate electron spins in two-dimensional semiconductor systems with the added advantage of electrical control of the spin-related photocurrent in spintronic applications.
A/T Run Geometry of B-form DNA Is Independent of Bound Methyl-CpG Binding Domain, Cytosine Methylation and Flanking Sequence
Authors: Chia Jyh Yea , Tan Wen Siang , Ng Chyan Leong , Hu Nien-Jen , Foo Hooi Ling , Ho Kok Lian 
Published: August 2016

AbstractDNA methylation in a CpG context can be recognised by methyl-CpG binding protein 2 (MeCP2) via its methyl-CpG binding domain (MBD). An A/T run next to a methyl-CpG maximises the binding of MeCP2 to the methylated DNA. The A/T run characteristics are reported here with an X-ray structure of MBD A140V in complex with methylated DNA. The A/T run geometry was found to be strongly stabilised by a string of conserved water molecules regardless of its flanking nucleotide sequences, DNA methylation and bound MBD. New water molecules were found to stabilise the Rett syndrome-related E137, whose carboxylate group is salt bridged to R133. A structural comparison showed no difference between the wild type and MBD A140V. However, differential scanning calorimetry showed that the melting temperature of A140V constructs in complex with methylated DNA was reduced by ~7 °C, although circular dichroism showed no changes in the secondary structure content for A140V. A band shift analysis demonstrated that the larger fragment of MeCP2 (A140V) containing the transcriptional repression domain (TRD) destabilises the DNA binding. These results suggest that the solution structure of MBD A140V may differ from the wild-type MBD although no changes in the biochemical properties of X-ray A140V were observed.
Laparoscopic surgery on broken points for uterine sarcoma in the early stage decrease prognosis
Authors: Liu Hong , Zhu Yi , Zhang Guo-Nan , Wang Chang , Li Chao , Shi Yu 
Published: August 2016

AbstractUterine sarcoma, a rare solid tumor in uterus, is difficult to identify in the early stage from some benign uterine tumors, such as uterine fibroids. Hence, uterine sarcoma may be treated in the same way as uterine fibroids; and this may not be found until pathological diagnosis. Consequently, this can lead to tumor’s abdominal spread, planting and local invasive growth, resulting in an early uterine sarcoma, an increased relapse rate after surgery and a decreased survival. Therefore, it’s important to avoid these unintended and iatrogenic complications through an accurate diagnosis and an appropriate surgical approach. The surgical staging and a complete resection of the tumor are both important for patients’ prognosis. In this review, we will discuss the laparoscopic surgery for uterine sarcoma in the early stage and patients’ prognosis.
Homogenised daily lake surface water temperature data generated from multiple satellite sensors: A long-term case study of a large sub-Alpine lake
Authors: Pareeth Sajid , Salmaso Nico , Adrian Rita , Neteler Markus 
Published: August 2016

AbstractAvailability of remotely sensed multi-spectral images since the 1980’s, which cover three decades of voluminous data could help researchers to study the changing dynamics of bio-physical characteristics of land and water. In this study, we introduce a new methodology to develop homogenised Lake Surface Water Temperature (LSWT) from multiple polar orbiting satellites. Precisely, we developed homogenised 1 km daily LSWT maps covering the last 30 years (1986 to 2015) combining data from 13 satellites. We used a split-window technique to derive LSWT from brightness temperatures and a modified diurnal temperature cycle model to homogenise data which were acquired between 8:00 to 17:00 UTC. Gaps in the temporal LSWT data due to the presence of clouds were filled by applying Harmonic ANalysis of Time Series (HANTS). The satellite derived LSWT maps were validated based on long-term monthly in-situ bulk temperature measurements in Lake Garda, the largest lake in Italy. We found the satellite derived homogenised LSWT being significantly correlated to in-situ data. The new LSWT time series showed a significant annual rate of increase of 0.020 °C yr−1 (*P < 0.05) and of 0.036 °C yr−1 (***P < 0.001) during summer.
Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism
Authors: Lea Richard G. , Byers Andrew S. , Sumner Rebecca N. , Rhind Stewart M. , Zhang Zulin , Freeman Sarah L. , Moxon Rachel , Richardson Holly M. , Green Martin , Craigon Jim , England Gary C. W. 
Published: August 2016

AbstractAdverse temporal trends in human semen quality and cryptorchidism in infants have been associated with exposure to environmental chemicals (ECs) during development. Here we report that a population of breeding dogs exhibit a 26 year (1988–2014) decline in sperm quality and a concurrent increased incidence of cryptorchidism in male offspring (1995–2014). A decline in the number of males born relative to the number of females was also observed. ECs, including diethylhexyl phthalate (DEHP) and polychlorinated biphenyl 153 (PCB153), were detected in adult dog testes and commercial dog foods at concentrations reported to perturb reproductive function in other species. Testicular concentrations of DEHP and PCB153 perturbed sperm viability, motility and DNA integrity in vitro but did not affect LH stimulated testosterone secretion from adult testis explants. The direct effects of chemicals on sperm may therefore contribute to the decline in canine semen quality that parallels that reported in the human.
The genetics of an early Neolithic pastoralist from the Zagros, Iran
Authors: Gallego-Llorente M. , Connell S. , Jones E. R. , Merrett D. C. , Jeon Y. , Eriksson A. , Siska V. , Gamba C. , Meiklejohn C. , Beyer R. , Jeon S. , Cho Y. S. , Hofreiter M. , Bhak J. , Manica A. , Pinhasi R. 
Published: August 2016

AbstractThe agricultural transition profoundly changed human societies. We sequenced and analysed the first genome (1.39x) of an early Neolithic woman from Ganj Dareh, in the Zagros Mountains of Iran, a site with early evidence for an economy based on goat herding, ca. 10,000 BP. We show that Western Iran was inhabited by a population genetically most similar to hunter-gatherers from the Caucasus, but distinct from the Neolithic Anatolian people who later brought food production into Europe. The inhabitants of Ganj Dareh made little direct genetic contribution to modern European populations, suggesting those of the Central Zagros were somewhat isolated from other populations of the Fertile Crescent. Runs of homozygosity are of a similar length to those from Neolithic farmers, and shorter than those of Caucasus and Western Hunter-Gatherers, suggesting that the inhabitants of Ganj Dareh did not undergo the large population bottleneck suffered by their northern neighbours. While some degree of cultural diffusion between Anatolia, Western Iran and other neighbouring regions is possible, the genetic dissimilarity between early Anatolian farmers and the inhabitants of Ganj Dareh supports a model in which Neolithic societies in these areas were distinct.
Inhibitor treatment of peripheral mononuclear cells from Parkinson’s disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker
Authors: Perera G. , Ranola M. , Rowe D. B. , Halliday G. M. , Dzamko N. 
Published: August 2016

AbstractActivating mutations in leucine-rich repeat kinase 2 (LRRK2) are strongly associated with increased risk of Parkinson’s disease (PD). Thus, LRRK2 kinase inhibitors are in development as potential Parkinson’s disease therapeutics. A reduction in the constitutive levels of phosphorylation on leucine-rich repeat kinase 2 (LRRK2) is currently used to measure target engagement of LRRK2 kinase inhibitors in cell and animal models. We aimed to determine if reduced phosphorylation of LRRK2 following inhibitor treatment is also a valid measure of target engagement in peripheral mononuclear cells from Parkinson’s disease patients. Peripheral mononuclear cells from idiopathic Parkinson’s disease patients and controls were treated ex vivo with two structurally distinct inhibitors of LRRK2, at four different doses and immunoblotting was used to assess the reduction in LRRK2 phosphorylation at Ser910, Ser935, Ser955 and Ser973. Both inhibitors showed no acute toxicity in primary cells and both inhibitors reduced the constitutive phosphorylation of LRRK2 at all measured residues equally in both control and Parkinson’s disease groups. Measuring the reduction in LRRK2 phosphorylation resulting from LRRK2 kinase inhibition, is thus a valid measure of acute peripheral target engagement in Parkinson’s disease patients. This is important if LRRK2 kinase inhibitors are to be used in a clinical setting.
Association between reduced white matter integrity in the corpus callosum and serotonin transporter gene DNA methylation in medication-naive patients with major depressive disorder
Authors: Won E , Choi S , Kang J , Kim A , Han K-M , Chang H S , Tae W S , Son K R , Joe S-H , Lee M-S , Ham B-J 
Published: August 2016

AbstractPrevious evidence suggests that the serotonin transporter gene (SLC6A4) is associated with the structure of brain regions that are critically involved in dysfunctional limbic-cortical network activity associated with major depressive disorder (MDD). Diffusion tensor imaging (DTI) and tract-based spatial statistics were used to investigate changes in white matter integrity in patients with MDD compared with healthy controls. A possible association between structural alterations in white matter tracts and DNA methylation of the SLC6A4 promoter region was also assessed. Thirty-five medication-naive patients with MDD (mean age: 40.34, male/female: 10/25) and age, gender and education level matched 49 healthy controls (mean age: 41.12, male/female: 15/34) underwent DTI. SLC6A4 DNA methylation was also measured at five CpG sites of the promoter region, and the cell type used was whole-blood DNA. Patients with MDD had significantly lower fractional anisotropy (FA) values for the genu of the corpus callosum and body of the corpus callosum than that in healthy controls (family-wise error corrected, P<0.01). Significant inverse correlations were observed between SLC6A4 DNA methylation and FA (CpG3, Pearson's correlation: r=−0.493, P=0.003) and axial diffusivity (CpG3, Pearson's correlation: r=−0.478, P=0.004) values of the body of the corpus callosum in patients with MDD. These results contribute to evidence indicating an association between epigenetic gene regulation and structural brain alterations in depression. Moreover, we believe this is the first report of a correlation between DNA methylation of the SLC6A4 promoter region and white matter integrity in patients with MDD.
The importance of gene–environment interactions in human obesity
Authors: Reddon Hudson , Guéant Jean-Louis , Meyre David 
Published: August 2016

The worldwide obesity epidemic has been mainly attributed to lifestyle changes. However, who becomes obese in an obesity-prone environment is largely determined by genetic factors. In the last 20 years, important progress has been made in the elucidation of the genetic architecture of obesity. In parallel with successful gene identifications, the number of gene–environment interaction (GEI) studies has grown rapidly. This paper reviews the growing body of evidence supporting gene–environment interactions in the field of obesity. Heritability, monogenic and polygenic obesity studies provide converging evidence that obesity-predisposing genes interact with a variety of environmental, lifestyle and treatment exposures. However, some skepticism remains regarding the validity of these studies based on several issues, which include statistical modelling, confounding, low replication rate, underpowered analyses, biological assumptions and measurement precision. What follows in this review includes (1) an introduction to the study of GEI, (2) the evidence of GEI in the field of obesity, (3) an outline of the biological mechanisms that may explain these interaction effects, (4) methodological challenges associated with GEI studies and potential solutions, and (5) future directions of GEI research. Thus far, this growing body of evidence has provided a deeper understanding of GEI influencing obesity and may have tremendous applications in the emerging field of personalized medicine and individualized lifestyle recommendations.
Actively actuated all dispenser printed thermochromic smart fabric device
Authors: Ahmed Z. , Wei Y. , Torah R. , Tudor J. 
Published: August 2016

An all printed actively actuated thermochromic (TC) smart fabric device is reported for the first time using a state of the art dispenser printing technique. The device consists of an ultraviolet curable TC ink with an activation temperature of 33°C actuated by conductive track‐based printed heater. The device is printed on untreated polyester cotton fabric. It offers a significant improvement in flexibility and design freedom over the state of the art TC fabric devices. The printed device changes colour from black to green in 10.8 s using 1.46 W DC power. It is shown that the time required for the device to change colour reduces tenfold with only a threefold increase in input power. It can be fabricated on other fabric or flexible substrates and in a range of colours and activation temperatures depending on the formulation chosen. The printed device is 30 × 21.5 mm which can be scaled up or down to suit the application. It can be used as an indicator in combination with sensors for smart fabric applications.
Dual‐wideband BPF with wide upper stopband using shorted stepped‐impedance stub‐loaded lowpass filter
Authors: Yang Qian , Jiao Yong‐Chang , Zhang Zheng 
Published: August 2016

A novel dual‐wideband bandpass filter (BPF) using shorted stepped‐impedance stub‐loaded lowpass filter is proposed. The stub introduces two transmission zeros (TZs) to divide the low passband into dual‐passband. By tuning the stub dimension parameters to control the TZs, the centre frequency and bandwidth (BW) for each passband can be tuned flexibly, and wide upper stopband can be realised. For demonstration, a dual‐wideband BPF operating at 1.08 and 3.05 GHz is designed, fabricated, and measured, and its 3 dB fractional BWs are 103.2 and 48.5%, respectively. The measured results are in good agreement with the simulated ones.
Increased water deficit decreases Douglas fir growth throughout western US forests
Authors: Restaino Christina M. , Peterson David L. , Littell Jeremy 
Published: August 2016

Significance
With ongoing public concern regarding climate change and recent drought that has affected many areas of the western United States, this study provides context and direct evidence for the negative impact of water stress on forest ecosystems. The response of trees to drought is a tangible example of the impacts of climate change on terrestrial ecosystems and is understandable by the public and a broad scientific audience. Any sustained change in the growth rates of trees also affects carbon sequestration, biodiversity maintenance, and ecosystem resilience, influencing both productivity and susceptibility to other disturbances.
Pourquoi une cinquième édition d’Interpréter pour traduire de Danica Seleskovitch et Marianne Lederer ?
Authors: Lederer Marianne 
Published: August 2016

Résumé
La première publication d’Interpréter pour traduire date de 1984. Les textes qui y sont réunis jettent les fondements de la Théorie Interprétative de la Traduction, une théorie cohérente expliquant le processus de l’interprétation et de la traduction. Les avancées des sciences cognitives ont peu à peu confirmé les constatations pragmatiques des auteurs, ce qui justifie cette cinquième édition par les Belles Lettres.
De la cognition à la socio-cognition à la lumière des échanges entre traducteurs
Authors: Plassard Freddie 
Published: August 2016

Résumé
Le présent article a pour objet de faire le point sur l’exploration d’un nouveau pan de la pratique de la traduction professionnelle, celui du recours des praticiens à des listes de diffusion créées à leur propre initiative. Ce dispositif repose sur l’échange de questions et de réponses destiné à résoudre des difficultés de traduction et témoigne d’une appropriation des virtualités de l’outil informatique à des fins dites « amicales » tout en fournissant aux traductologues un nouveau poste d’observation. La pratique décrite s’inscrit dans l’ensemble aujourd’hui répertorié sous le nom de pratiques collaboratives en traduction, sans pour autant en relever à part entière. Elle sera abordée ici en termes descriptifs formels sous l’angle du cadre et des rôles participatifs puis fonctionnels en termes d’apport cognitif et sera l’occasion d’envisager les différences éventuelles entre les notions de réseau et de communauté tout en débouchant sur la mise en évidence de nouvelles modalités cognitives à la charnière de l’individuel et du collectif.