bluuebunny/crossref_metadata_2025_split huggingface dataset:
Binge‐eating disorder in the Swedish national registers: Somatic comorbidity
Authors: Thornton Laura M. , Watson Hunna J. , Jangmo Andreas , Welch Elisabeth , Wiklund Camilla , von Hausswolff‐Juhlin Yvonne , Norring Claes , Herman Barry K. , Larsson Henrik , Bulik Cynthia M. 
Published: September 2016

ABSTRACTObjectiveTo evaluate associations between binge‐eating disorder (BED) and somatic illnesses and determine whether medical comorbidities are more common in individuals who present with BED and comorbid obesity.MethodCases (n = 850) were individuals with a BED diagnosis in the Swedish eating disorders quality registers. Ten community controls were matched to each case on sex, and year, month, and county of birth. Associations of BED status with neurologic, immune, respiratory, gastrointestinal, skin, musculoskeletal, genitourinary, circulatory, and endocrine system diseases were evaluated using conditional logistic regression models. We further examined these associations by adjusting for lifetime psychiatric comorbidity. Amongst individuals with BED, we explored whether comorbid obesity was associated with risk of somatic disorders.ResultsBED was associated with most classes of diseases evaluated; strongest associations were with diabetes [odds ratio (95% confidence interval) = 5.7 (3.8; 8.7)] and circulatory systems [1.9 (1.3; 2.7)], likely indexing components of metabolic syndrome. Amongst individuals with BED, those with comorbid obesity were more likely to have a lifetime history of respiratory [1.5 (1.1; 2.1)] and gastrointestinal [2.6 (1.7; 4.1)] diseases than those without comorbid obesity. Increased risk of some somatic disease classes in individuals with BED was not simply due to obesity or other lifetime psychiatric comorbidity.DiscussionThe association of BED with many somatic illnesses highlights the morbidity experienced by individuals with BED. Clinicians treating patients with BED should be vigilant for medical comorbidities. Nonpsychiatric providers may be the first clinical contact for those with BED underscoring the importance of screening in primary care. © 2016 The Authors International Journal of Eating Disorders Published by Wiley Periodicals, Inc. (Int J Eat Disord 2017; 50:58–65)
Insufficient reduction in heart rate during hospitalization despite beta‐blocker treatment in acute decompensated heart failure: insights from the ASCEND‐HF trial
Authors: Kitai Takeshi , Grodin Justin L. , Mentz Robert J. , Hernandez Adrian F. , Butler Javed , Metra Marco , McMurray John J. , Armstrong Paul W. , Starling Randall C. , O'Connor Christopher M. , Swedberg Karl , Tang W.H. Wilson 
Published: September 2016

AimsHeart failure (HF) can be associated with a higher resting heart rate (HR), and an elevated HR is associated with adverse long‐term events. However, the mechanistic and causal role of HR in HF is unclear. This study aimed to investigate changes in HR during hospitalization, and the association between discharge HR and clinical outcomes as well as an interaction with beta‐blocker therapy in patients with acute decompensated HF (ADHF).Methods and resultsWe studied 2906 patients with an LVEF ≤35%, without AF, who were enrolled in the ASCEND‐HF trial. A total of 2492 (85.8%) patients had a HR ≥70 b.p.m. at baseline and 1580 (54.4%) patients were on beta‐blocker treatment. Although HR was gradually reduced from baseline to discharge (85.5 ± 15.9 b.p.m. at baseline, 81.7 ± 14.1 b.p.m. at 24 h from treatment initiation, and 79.1 ± 12.2 b.p.m. at discharge), 80.2% of the patients still had a HR ≥70 b.p.m. at discharge. Patients with a HR ≥70 b.p.m. at discharge had significantly lower survival rates than those with a HR <70 b.p.m. (adjusted hazard ratio 1.02, 95% confidence interval 1.01–1.04, P = 0.002). Moreover, HR at discharge had a curvilinear association with mortality, and had no significant interaction effect with beta‐blocker therapy at discharge (P = 0.82).ConclusionsDespite current beta‐blocker therapy, many patients with hospitalized ADHF with reduced LVEF have relatively high discharge HR, and discharge HR is associated with higher mortality. Further studies are warranted to determine the optimal strategy for HR control to improve outcomes.
Effects of the herbicide surfactant MON 0818 on oviposition and viability of eggs of the ramshorn snail (Planorbella pilsbryi)
Authors: Prosser Ryan S. , Rodriguez-Gil Jose L. , Solomon Keith R. , Sibley Paul K. , Poirier David G. 
Published: September 2016

Abstract

The surfactant mixture MON 0818 is an adjuvant in various commercial formulations of the herbicide glyphosate. Initial studies have shown that MON 0818 is more toxic to aquatic animals than the active ingredient. However, few studies have examined the effect of exposure to MON 0818 on species of mollusks, and no studies have examined the effect on gastropods. The present study investigated the effect of acute exposure (96 h) of MON 0818 to the eggs, juveniles, and adults of the file ramshorn snail (Planorbella pilsbryi). Concentrations of MON 0818 up to 9.9 mg/L did not have a significant effect on the viability of eggs (p &gt; 0.05). Juvenile snails (50% lethal concentration [LC50] = 4.0 mg/L) were more sensitive than adult snails (LC50 = 4.9–9.1 mg/L). Oviposition was inhibited by exposure to MON 0818 (median effective concentration [EC50] = 0.4–2.0 mg/L). However, oviposition resumed when snails were removed to clean water, even after 96-h exposure to up to 4.9 mg/L of MON 0818. Exposure to a concentration ≥2.7 mg/L caused visible damage to the tentacles of adult snails, which could potentially impact chemoreception. A deterministic hazard assessment indicated that environmentally relevant concentrations of MON 0818 could pose a hazard to the deposition of eggs. However, because of the relatively short half-life of MON 0818 in aquatic systems and the ability of snails to resume oviposition following the dissipation of MON 0818, environmentally relevant concentrations of MON 0818 likely pose a de minimis risk to populations of ramshorn snails. Environ Toxicol Chem 2017;36:522–531. © 2016 SETAC
Hybrid precoding with compressive sensing based limited feedback in massive MIMO systems
Authors: Jiang Dongmei , Natarajan Balasubramaniam 
Published: September 2016

ABSTRACTMassive multiple‐input multiple‐output (MIMO) systems are an enabling technology for high capacity 5G cellular networks. However, the high hardware complexity and power consumption make it difficult to apply conventional MIMO precoding schemes in massive MIMO. Additionally, thanks to the large channel dimension, applying traditional limited feedback schemes for obtaining channel state information at the transmitter is a challenge. In this paper, we develop a low‐complexity hybrid precoding scheme for multiuser massive MIMO system in mmWave communication. We design the analog beamformer as the conjugate transpose of the downlink channel from base station to the users. Then zero‐forcing baseband processing is applied over the effective channel. We get the optimal power allocation policy and compare its performance with average power allocation based on channel state information at transmitter. The channel state information at transmitter is obtained via a compressive sensing based limited feedback strategy. The effectiveness of hybrid precoding relies on the feedback quality of channel state information, which relies on the compression ratio. We quantify the impact of compression ratio on precoder performance and derive an upper bound on the sum rate. Simulation results illustrate the performance of our proposed scheme and the effect of compressive sensing based limited feedback.
Serum free immunoglobulin light chain fingerprint identifies a subset of newly diagnosed multiple myeloma patients with worse outcome
Authors: Avivi Irit , Cohen Yael C. , Joffe Erel , Benyamini Noam , Held‐Kuznetsov Viki , Trestman Svetlana , Terpos Evangelos , Dimopoulos Meletios A. , Kastritis Efstathios 
Published: September 2016

AbstractMultiple myeloma (MM) is a multi–subclonal malignancy with relatively high heterogeneity. Patients who initially presented with both monoclonal‐protein (MP) and free light chain (FLC) secretion but then relapsed with a light chain escape pattern have been shown to reflect disease clonal evolution and to bare a worse prognosis. We hypothesized that a discordant MP/FLC pattern at diagnosis may reflect a similar clonal evolution that had occurred prior to diagnosis of active myeloma, conferring a worse outcome. We analyzed 255 consecutive newly diagnosed MM patients who received first line bortezomib‐based therapy between 2007 and 2014, hypothesizing that their MP/FLC fingerprint at diagnosis reflects clonal heterogeneity and, therefore, affects outcome. An involved FLC level ≥ 700 mg/L and MP ≥ 2.5 g/L were used as cutoffs for low vs high FLC and MP levels, respectively. Patients were divided into 4 subgroups according to their involved FLC and MP blood levels at diagnosis: HiLC and HiMP for patients with either a predominant FLC or a predominant MP, respectively, and HiLC‐MP and LoLC‐MP when both FLC and MP were increased or decreased, respectively. There were 68 (27%) patients with HiLC, which presented more often with International Staging System‐3 stage (P < .0001). Multivariate analysis showed that HiLC was associated with a 5.1‐fold risk for mortality in a multivariate model (95% confidence interval [CI], 1.34‐19.68). Both HiLC and HiLC‐MP phenotypes were associated with shorter progression‐free survival (hazard ratio of 2.66 [95% CI, 1.33‐5.32] and 2.82 [95% CI, 1.37‐5.83], respectively), independently of other prognostic factors, including the use of autograft. Thus, we identified an LC predominant secretory fingerprint (HiLC phenotype) at diagnosis as a potential independent risk factor that may affect disease control and survival in newly diagnosed MM patients treated with bortezomib‐based induction therapy; this may represent increased subclonal heterogeneity.
Agricultural land management options after the Chernobyl and Fukushima accidents: The articulation of science, technology, and society
Authors: Vandenhove Hildegarde , Turcanu Catrinel 
Published: September 2016

Abstract
The options adopted for recovery of agricultural land after the Chernobyl and Fukushima accidents are compared by examining their technical and socio-economic aspects. The analysis highlights commonalities such as the implementation of tillage and other types of countermeasures and differences in approach, such as preferences for topsoil removal in Fukushima and the application of K fertilizers in Chernobyl. This analysis shows that the recovery approach needs to be context-specific to best suit the physical, social, and political environment. The complex nature of the decision problem calls for a formal process for engaging stakeholders and the development of adequate decision support tools. Integr Environ Assess Manag 2016;12:662–666. © 2016 SETAC
The importance of early investigation and publishing in an emergent health and environment crisis
Authors: Murase Kaori 
Published: September 2016

Abstract
To minimize the damage resulting from a long-term environmental disaster such as the 2011 Fukushima nuclear accident in Japan, early disclosure of research data by scientists and prompt decision making by government authorities are required in place of careful, time-consuming research and deliberation about the consequences and cause of the accident. A Bayesian approach with flexible statistical modeling helps scientists and encourages government authorities to make decisions based on environmental data available in the early stages of a disaster. It is evident from Fukushima and similar accidents that classical research methods involving statistical methodologies that require rigorous experimental design and complex data sets are too cumbersome and delay important actions that may be critical in the early stages of an environmental disaster. Integr Environ Assess Manag 2016;12:680–682. © 2016 SETAC.
The need to integrate laboratory- and ecosystem-level research for assessment of the ecological impact of radiation
Authors: Bréchignac François 
Published: September 2016

Abstract
Despite the fact that the Chernobyl and Fukushima accidents have both stimulated research on the environmental impact of radiation, interpretations about the occurrence of ecological effects in the contaminated areas still do not converge. In an effort to improve the situation and progress toward better general scientific understanding of ecological impacts of radiation, reasons that may explain the disagreements and discrepancies are explored. The divergence in interpretations of the impacts from both nuclear accidents arises from differences in methodological and conceptual inference strategies (a cultural issue) more so than fundamental differences in the processes governing ecological harm. Improved integration of scientific communities that use different study approaches should be encouraged to better understand and monitor the determination of the ecological impacts of radiation. Integr Environ Assess Manag 2016;12:673–676. © 2016 SETAC.
Linear Programming Application for Irrigation Network Management–Implementation in the Irrigation Network Region of Pinios (Central Greece)
Authors: Sakellariou‐Makrantonaki M. , Tzimopoulos C. , Giouvanis V. 
Published: September 2016

AbstractThe purpose of this study is to find the optimal economical organization of agricultural production, by minimizing the use of available water resources. This purpose can be achieved by combining operational research and hydrology for the development of the appropriate methodology. For the study, the area of the Local Organization for Land Reclamation (LOLR) of Pinios was chosen, as this is a representative part of the plain of Thessaly and the findings could contribute to the total gross value of production in the region (central Greece). The method of linear programming was used for the optimization of agricultural production. The first results obtained within the predefined constraints led us to crop restructuring, while economic profit was increased by 41.7% and water saving reached 4.2%. Copyright © 2016 John Wiley & Sons, Ltd.
Toxic effects of 4‐methylthio‐3‐butenyl isothiocyanate (Raphasatin) in the rat urinary bladder without genotoxicity
Authors: Suzuki Isamu , Cho Young‐Man , Hirata Tadashi , Toyoda Takeshi , Akagi Jun‐ichi , Nakamura Yasushi , Sasaki Azusa , Nakamura Takako , Okamoto Shigehisa , Shirota Koji , Suetome Noboru , Nishikawa Akiyoshi , Ogawa Kumiko 
Published: September 2016

AbstractWe recently reported that 4‐methylthio‐3‐butenyl isothiocyanate (MTBITC) exerts chemopreventive effects on the rat esophageal carcinogenesis model at a low dose of 80 ppm in a diet. In contrast, some isothiocyanates (ITCs) have been reported to cause toxic effects, promotion activity, and/or carcinogenic potential in the urinary bladder of rats. In the present study, we investigated whether MTBITC had toxic effects in the urinary bladder similar to other ITCs, such as phenethyl ITC (PEITC). First, to examine the early toxicity of MTBITC, rats were fed a diet supplemented with 100, 300 or 1000 ppm MTBITC for 14 days. Treatment with 1000 ppm MTBITC caused increased organ weights and histopathological changes in the urinary bladder, producing lesions similar to those of 1000 ppm PEITC. In contrast, rats treated with 100 or 300 ppm MTBITC showed no signs of toxicity. Additionally, we performed in vivo genotoxicity studies to clarify whether MTBITC may exhibit a carcinogenic potential through a genotoxic mechanism in rats. Rats were treated with MTBITC for 3 days at doses of 10, 30 or 90 mg kg−1 body weight by gavage, and comet assays in the urinary bladder and micronucleus assays in the bone marrow were performed. No genotoxic changes were observed after treatment with MTBITC at all doses. Overall, these results suggested that the effects of MTBITC in the rat urinary bladder are less than those of PEITC, but that MTBITC could have toxic effects through a nongenotoxic mechanism in the urinary bladder of rats at high doses. Copyright © 2016 John Wiley & Sons, Ltd.
Hydrotreating and hydrothermal treatment of alkaline lignin as technological valorization options for future biorefinery concepts: a review
Authors: Rutten Cathelijne , Ramírez Andrea , Posada Duque John 
Published: September 2016

AbstractLignin has the potential to be a sustainable resource for producing biobased chemicals (e.g. phenols, aromatic hydrocarbons, vanillin) for multiple applications. However, given its heterogeneous and rigid structure, its efficient conversion to value‐added products remains one of the most important limiting factors for the successful viability of the biobased economy. Hydrotreating and hydrothermal treatment (including liquefaction, gasification and wet oxidation) are promising technologies that can convert lignin into biobased products. This review article provides a literature overview of how key process parameters of hydrotreating and hydrothermal treatment (operating conditions, catalysts, solvents, type of starting lignin) may influence the conversion of alkaline lignin into valuable chemical products. It was observed that low selectivity to products (and subsequent required separation and purification) and char formation are the main hurdles for effective conversion of alkaline lignin. However, experimental work in alternative catalytic systems, solvents and hydrogen sources has shown that promising opportunities exist to overcome these drawbacks. Certain catalysts (e.g. Ru/Al2O3) have been found to improve selectivity and the use of alcohol solvents (especially methanol or ethanol) as a hydrogen source has been found to improve product yields and reduce char formation at lower working temperatures and pressures. © 2016 Society of Chemical Industry
Oximetric angiosome imaging in diabetic feet
Authors: Zheng Jie , Muccigrosso David , Zhang Xiaodong , An Hongyu , Coggan Andrew R. , Adil Bashir , Hildebolt Charles F. , Vemuri Chandu , Geraghty Patrick , Hastings Mary K. , Mueller Michael J. 
Published: September 2016

PurposeTo develop a noncontrast oximetric angiosome imaging approach to assess skeletal muscle oxygenation in diabetic feet.Materials and MethodsIn four healthy and five subjects with diabetes, the feasibility of foot oximetry was examined using a 3T clinical magnetic resonance imaging (MRI) scanner. The subjects' feet were scanned at rest and during a toe‐flexion isometric exercise. The oxygen extraction fraction of skeletal muscle was measured using a susceptibility‐based MRI method. Our newly developed MR foot oximetric angiosome model was compared with the traditional angiosome model in the assessment of the distribution of oxygen extraction fraction.ResultsUsing the traditional angiosome during the toe‐flexion exercise, the oxygen extraction fraction in the medial foot of healthy subjects increased (4.9 ± 3%) and decreased (–2.7 ± 4.4%) in subjects with diabetes (difference = 7.6%; 95% confidence interval = –13.7 ± 1.4; P = 0.02). Using the oximetric angiosome, the percent difference in the areas of oxygen extraction fraction within the 0.7–1.0 range (expected oxygen extraction fraction during exercise) between rest and exercise was higher in healthy subjects (8 ± 4%) than in subjects with diabetes (4 ± 4%; P = 0.02).ConclusionThis study demonstrates the feasibility of measuring skeletal muscle oxygen extraction fraction in the foot muscle during a toe‐flexion isometric exercise. Instead of assessing oxygen extraction fraction in a foot muscle region linked to a supplying artery (traditional angiosome), the foot oximetric angiosome model assesses oxygen extraction fraction by its different levels in all foot muscle regions and thus may be more appropriate for assessing local ischemia in ulcerated diabetic feet. J. Magn. Reson. Imaging 2016. J. MAGN. RESON. IMAGING 2016;44:1–1.
A nomogram predicting contralateral central neck lymph node metastasis for papillary thyroid carcinoma
Authors: Hei Hu , Song Yongping , Qin Jianwu 
Published: September 2016

Background and ObjectivesCentral compartment neck dissection (CCND) is recommended for patients with papillary thyroid carcinoma (PTC). However, whether to perform contralateral CCND remains unclear. An individualized estimation of the contralateral central neck metastasis (CNM) risk would assist in the tailoring of treatment for PTC patients.MethodsConsecutive patients who underwent bilateral CCND for unilateral PTC between 2012 and 2014 in a tertiary center were identified. The clinicopathological data of 142 patients were analyzed retrospectively. The variables that had clinical significance in the final multivariate logistic regression model were built into a nomogram to assess the risk of metastasis of the contralateral central compartment. This model was internally validated using bootstrap resampling.ResultsThis nomogram demonstrated good calibration and discrimination, with a concordance index of 0.834 (bootstrap corrected, 0.824). The variables with the greatest influence on the risk of contralateral CNM in this model included tumor size, the number of positive lymph nodes, and extranodal extension in the ipsilateral central neck.ConclusionsThis nomogram integrates three variables to estimate an individualized risk of contralateral CNM in unilateral PTC patients. This model may assist in individual decision‐making regarding contralateral CCND and help avoid the over‐ and under‐treatment of PTC. J. Surg. Oncol. 2016;114:703–707. © 2016 Wiley Periodicals, Inc.
Surgical excision margin for primary acral melanoma
Authors: Lee Kyeong‐Tae , Kim Eun‐Ji , Lee Dong‐Youn , Kim Jung‐Han , Jang Kee‐Taek , Mun Goo‐Hyun 
Published: September 2016

Background and ObjectivesThis study aimed to evaluate treatment outcomes of acral melanoma (AM) based on the excision margin.MethodsA retrospective cohort study was conducted for patients with primary AM, analyzing recurrence rates, local and in‐transit recurrence‐free survival (LITRFS), disease‐free survival (DFS), and melanoma‐specific survival (MSS).ResultsData from 129 patients of AM were analyzed. In 53 patients with thin AM (thickness ≤1 mm), neither recurrence nor mortality occurred regardless of whether the excision margin was >1 cm or not. Seventy‐six patients had thick AM (thickness >1 mm), including 36 treated with a <2 cm excision margin and 40 with a 2 cm margin. Multivariate analyses revealed that a 2 cm margin was associated with a reduced rate of local recurrence (HR, 0.120; P‐value = 0.023) and LITR (HR, 0.187; P‐value = 0.013) compared with a <2 cm margin. DFS and MSS did not differ between the two groups.ConclusionsThin AM were successfully treated with a 1 cm excision margin. For thick AM, a 2 cm excision margin provided improved local control, compared with a <2 cm margin; however, this benefit did not translate into a survival gain. J. Surg. Oncol. 2016;114:933–939. © 2016 Wiley Periodicals, Inc.