Genetic analysis of over one million people identifies 535 novel loci for blood pressure
Authors: Evangelou Evangelos , Warren Helen R , Mosen-Ansorena David , Mifsud Borbala , Pazoki Raha , Gao He , Ntritsos Georgios , Dimou Niki , Cabrera Claudia P , Karaman Ibrahim , Ng Fu Liang , Evangelou Marina , Witkowska Katarzyna , Tzanis Evan , Hellwege Jacklyn N , Giri Ayush , Velez Edwards Digna R , Sun Yan V , Cho Kelly , Gaziano J.Michael , Wilson Peter WF , Tsao Philip S , Kovesdy Csaba P , Esko Tonu , Mägi Reedik , Milani Lili , Almgren Peter , Boutin Thibaud , Debette Stéphanie , Ding Jun , Giulianini Franco , Holliday Elizabeth G , Jackson Anne U , Li-Gao Ruifang , Lin Wei-Yu , Luan Jian'an , Mangino Massimo , Oldmeadow Christopher , Prins Bram , Qian Yong , Sargurupremraj Muralidharan , Shah Nabi , Surendran Praveen , Thériault Sébastien , Verweij Niek , Willems Sara M , Zhao Jing-Hua , Amouyel Philippe , Connell John , de Mutsert Renée , Doney Alex SF , Farrall Martin , Menni Cristina , Morris Andrew D , Noordam Raymond , Paré Guillaume , Poulter Neil R , Shields Denis C , Stanton Alice , Thom Simon , Abecasis Gonçalo , Amin Najaf , Arking Dan E , Ayers Kristin L , Barbieri Caterina M , Batini Chiara , Bis Joshua C , Blake Tineka , Bochud Murielle , Boehnke Michael , Boerwinkle Eric , Boomsma Dorret I , Bottinger Erwin P , Braund Peter S , Brumat Marco , Campbell Archie , Campbell Harry , Chakravarti Aravinda , Chambers John C , Chauhan Ganesh , Ciullo Marina , Cocca Massimiliano , Collins Francis , Cordell Heather J , Davies Gail , de Borst Martin H , de Geus Eco J , Deary Ian J , Deelen Joris , Del Greco Fabiola M , Demirkale Cumhur Yusuf , Dörr Marcus , Ehret Georg B , Elosua Roberto , Enroth Stefan , Erzurumluoglu A.Mesut , Ferreira Teresa , Frånberg Mattias , Franco Oscar H , Gandin Ilaria , Gasparini Paolo , Giedraitis Vilmantas , Gieger Christian , Girotto Giorgia , Goel Anuj , Gow Alan J , Gudnason Vilmundur , Guo Xiuqing , Gyllensten Ulf , Hamsten Anders , Harris Tamara B , Harris Sarah E , Hartman Catharina A , Havulinna Aki S , Hicks Andrew A , Hofer Edith , Hofman Albert , Hottenga Jouke-Jan , Huffman Jennifer E , Hwang Shih-Jen , Ingelsson Erik , James Alan , Jansen Rick , Jarvelin Marjo-Riitta , Joehanes Roby , Johansson Åsa , Johnson Andrew D , Joshi Peter K , Jousilahti Pekka , Jukema J Wouter , Jula Antti , Kähönen Mika , Kathiresan Sekar , Keavney Bernard D , Khaw Kay-Tee , Knekt Paul , Knight Joanne , Kolcic Ivana , Kooner Jaspal S , Koskinen Seppo , Kristiansson Kati , Kutalik Zoltan , Laan Maris , Larson Marty , Launer Lenore J , Lehne Benjamin C , Lehtimäki Terho , Levy Daniel , Liewald David CM , Lin Li , Lind Lars , Lindgren Cecilia M , Liu Yongmei , Loos Ruth JF , Lopez Lorna M , Lu Lingchan , Lyytikäinen Leo-Pekka , Mahajan Anubha , Mamasoula Chrysovalanto , Marrugat Jaume , Marten Jonathan , Milaneschi Yuri , Morgan Anna , Morris Andrew P , Morrison Alanna C , Munson Peter J , Nalls Mike A , Nandakumar Priyanka , Nelson Christopher P , Newton-Cheh Christopher , Niiranen Teemu , Nolte Ilja M , Nutile Teresa , Oldehinkel Albertine J , Oostra Ben A , O'Reilly Paul F , Org Elin , Padmanabhan Sandosh , Palmas Walter , Palotie Arno , Pattie Alison , Penninx Brenda WJH , Perola Markus , Peters Annette , Polasek Ozren , Pramstaller Peter P , Quang Tri Nguyen , Raitakari Olli T , Ren Meixia , Rettig Rainer , Rice Kenneth , Ridker Paul M , Reid Janina S , Riese Harriëtte , Ripatti Samuli , Robino Antonietta , Rose Lynda M , Rotter Jerome I , Rudan Igor , Ruggiero Daniella , Saba Yasaman , Sala Cinzia F , Salomaa Veikko , Samani Nilesh J , Sarin Antti-Pekka , Schmidt Rheinhold , Schmidt Helena , Shrine Nick , Siscovick David , Smith Albert V , Schneider Harold , Sõber Siim , Sorice Rossella , Starr John M , Stott David J , Strachan David P , Strawbridge Rona J , Sundström Johan , Swertz Morris A , Taylor Kent D , Teumer Alexander , Tobin Martin D , Toniolo Daniela , Traglia Michela , Trompet Stella , Tuomilehto Jaakko , Tzourio Christophe , Uitterlinden André G , Vaez Ahmad , van der Most Peter J , van Duijn Cornelia M , Vergnaud Anne-Claire , Verwoert Germaine C , Vitart Veronique , Völker Uwe , Vollenweider Peter , Vuckovic Dragana , Watkins Hugh , Wild Sarah H , Willemsen Gonneke , Wilson James F , Wright Alan F , Yao Jie , Zemunik Tatijana , Zhang Weihua , Attia John R , Butterworth Adam S , Chasman Dan , Conen David , Cucca Francesco , Danesh John , Hayward Caroline , Howson Joanna MM , Laakso Markku , Lakatta Edward G , Langenberg Claudia , Melander Ollie , Mook-Kanamori Dennis O , Munroe Patricia B , Palmer Colin NA , Risch Lorenz , Scott Robert A , Scott Rodney J , Sever Peter , Spector Tim D , van der Harst Pim , Wareham Nicholas J , Zeggini Eleftheria , Brown Morris J , Metspalu Andres , Hung Adriana M , O'Donnell Christopher J , Edwards Todd L ,   on behalf of the Million Veteran Program, Psaty Bruce M. , Tzoulaki Ioanna , Barnes Michael R , Wain Louise V , Elliott Paul , Caulfield Mark J 
Published: October 2017

AbstractHigh blood pressure is the foremost heritable global risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits to date (systolic, diastolic, pulse pressure) in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared loci influencing lifestyle exposures. Our findings offer the potential for a precision medicine strategy for future cardiovascular disease prevention.