bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competencias transversales del tutor clínico de las especializaciones en Enfermería: resultados de la autoevaluación
Authors: Montero-Díaz Rodrigo , González-Juárez Graciela , Ponce-Gómez Gandhy 
Published: September 2024

Objective: Analyze the transversal competencies of clinical tutors through diagnostic self-assessment to identify strengths and areas of opportunity in clinical tutoring.
Material and methods: This is a quantitative, descriptive and cross-sectional study. The sample consisted of 95 clinical tutors hired to teach academic activities related to clinical practice in the specializations and who were willing to participate. A self assessment scale was designed that contains three dimensions and subdimensions of transversal competence and was validated by expert judging and a pilot study. It was applied through the Google Forms platform. The total variable was calculated and the corresponding percentages were obtained.
Results: A differentiated diagnosis was made in strengths and areas of opportunity in the transversal competencies of the clinical tutor. In general, the self-assessment demonstrates that high percentages in the dimensions considered with not significant variations in these.
Conclusions: The transversal competencies of the clinical tutor demand differentiated training to achieve a profile that contributes to the development of transversal competencies such as the ability to design learning scenarios, specialized care and the ability to evaluate learning in real practice scenarios.
Keywords: Mentor; Preceptorship, Tutor; Competency-based education.
EFFECT OF MORINGA (Moringa oleifera) LEAF EXTRACT ON IN VITRO INHIBITION OF Candida albicans BIOFILM
Authors: Sulistyani Herastuti , Sulastri Siti , Agustina Dewi , A'yun Quroti 
Published: September 2024

Background: Oral candidiasis is an opportunistic infection in the oral cavity. This infection is caused by the fungus Candida albicans. The most important virulent attribute of this fungus is its ability to form biofilms, which can adhere to mucosa, epithelial lining, organs, prostheses or dentures. The formed biofilm is resistant to antifungal drugs. Objectives: The purpose of this study was to determine the effect of Moringa (Moringa oleifera) leaf extract on the inhibition of Candida albicans biofilm formation in vitro. Methods: This type of research is experimental study using post tests with control group design. Fungus used in this study was Candida albicans ATCC 10231. Determination of minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) were conducted by microdilution method. Inhibition test of C. albicans biofilm formation was carried out using the polystyrene microplate assay method. Concentration of extracts used in this study were 12.5%, 6.25%, 3.13% and 1.57%. Inhibitory activity of biofilm was measured using a crystal violet (CV) assay. Results: The results showed that MIC of Moringa leaf extract against the fungus C. albicans was at a concentration of 6.25%. Moringa leaf extract starting at a concentration of 3.13% already has had ability to inhibit formation of C. albicans biofilm. Conclusion: It can be concluded that Moringa leaf extract can inhibit formation of Candida albicans biofilm, so it can be developed as an alternative herbal ingredient to prevent oral candidiasis.EFFECT OF MORINGA (Moringa oleifera) LEAF EXTRACT ON IN VITRO INHIBITION OF Candida albicans BIOFILM
Exploring intra-specific variability as an adaptive strategy to climate change: Response of 21 grapevine cultivars grown under drought conditions
Authors: Serrano Parra Argimiro Sergio , Martínez Gascueña Jesús , Alonso Gonzalo L. , Cebrián Tarancón Cristina , Mena Morales Adela , Chacón Vozmediano Juan L. 
Published: September 2024

In recent decades, as a consequence of climate change, grape ripening is occurring under warmer and drier conditions, resulting in losses in the yield and quality of wine grapes. Several alternatives may reduce these negative effects. One that stands out for its potential for long-term adaptation is the selection of better-adapted plant material. For this purpose, during two consecutive years, several agronomic and quality parameters were recorded in 21 grapevine cultivars grown under two water stress levels (moderate and severe). The results revealed that some cultivars considered a minority, as well as others recently recovered from the viticultural heritage that had almost become extinct, could offer a similar and even better response to drought than other widespread cultivars. In particular, Maquías, Montonera del Casar, and Tortozona Tinta stood out for their high total acidity; Tinto Fragoso and Tinto Velasco for their high anthocyanin concentration; and Albillo Dorado and Moscatel Serrano for their high varietal aromatic potential. These cultivars could contribute to diversifying varietal offerings and to maintaining the sustainability of the wine sector in the coming decades.
Monitoring Macroinvertebrates as Bioindicators and Water Physicochemical Parameters in the Tambak Rejo River, Sidoarjo.
Authors: Robbi Adinda Atthiyatur , Munfarida Ida , Oktorina Sarita , Suprayogi Dedy , Setyowati Rr Diah Nugraheni 
Published: September 2024

Sungai Tambak Rejo merupakan sungai yang berada di desa Tambak Rejo, Kabupaten Sidoarjo. Sungai Tambak Rejo, merupakan sungai utama yang mengaliri tiga kelurahan yaitu tambak sumur, tambak rejo dan tambak sawah. Berbagai karakteristik lokasi menjadikan sungai ini memiliki berbagai limbah yang dihasilkan baik limbah domestik, limbah industri dan limbah pertanian. Hal ini tentunya dapat menyebabkan penurunan kuaitas air sungai, apabila limbah yang dihasilkan tidak diolah dengan benar. Pemantauan makroinvertebrata sebagai bioindikator kualitas air sungai merupakan tujuan penelitian ini, dimana biota ini dapat digunakan sebagai indikator biologis karena adanya habitat dan keberadaannya sangat dipengaruhi secara langsung di dalam perairan. Pengukuran parameter fisik-kimia air juga dilakukan untuk menyesuaikan kualitas air sungai dengan baku mutu yang telah ditetapkan, paramet yang diukur ialah Ph, Suhu, TSS, BOD, COD dan Kadar mangan. analisis makroinvertebrata menggunakan dua metode yakni, metode indeks biotilik dan metode indeks biotik, Pada Indeks Biotilik, Titik I dan Titik II dikategorikan sebagai sungai tercemar sedang dan Titik III diktegorikan sebagai sungai tercemar ringan. Pada Indeks Biotik, Titik I tergolong pada perairan kotor sedang Titik II tergolong pada perairan kotor sedang dan berat. beberapa parameter fisika-kimia yang tidak sesuai dengan baku mutu, yakni BOD, pada titik I, titik II. COD, pada titik I-III.
Levels of Synovial Fluid Inflammatory Biomarkers on Day of Arthroscopic Partial Meniscectomy Predict Long-Term Outcomes and Conversion to TKA
Authors: Moore Michael R. , DeClouette Brittany , Wolfe Isabel , Kingery Matthew T. , Sandoval-Hernandez Carlos , Isber Ryan , Kirsch Thorsten , Strauss Eric J. 
Published: September 2024

Background:
The purpose of the present study was to evaluate the relationships of the concentrations of pro- and anti-inflammatory biomarkers in the knee synovial fluid at the time of arthroscopic partial meniscectomy (APM) to long-term patient-reported outcomes (PROs) and conversion to total knee arthroplasty (TKA).

Methods:
A database of patients who underwent APM for isolated meniscal injury was analyzed. Synovial fluid had been aspirated from the operatively treated knee prior to the surgical incision, and concentrations of pro- and anti-inflammatory biomarkers (RANTES, IL-6, MCP-1, MIP-1β, VEGF, TIMP-1, TIMP-2, IL-1RA, MMP-3, and bFGF) were quantified. Prior to surgery and again at the time of final follow-up, patients were asked to complete a survey that included a visual analog scale (VAS) for pain and Lysholm, Tegner, and Knee injury and Osteoarthritis Outcome Score-Physical Function Short Form (KOOS-PS) questionnaires. Clustering analysis of the 10 biomarkers of interest was carried out with the k-means algorithm.

Results:
Of the 82 patients who met the inclusion criteria for the study, 59 had not undergone subsequent ipsilateral TKA or APM, and 43 (73%) of the 59 completed PRO questionnaires at long-term follow-up. The mean follow-up time was 10.6 ± 1.3 years (range, 8.7 to 12.4 years). Higher concentrations of individual pro-inflammatory biomarkers including MCP-1 (β = 13.672, p = 0.017) and MIP-1β (β = −0.385, p = 0.012) were associated with worse VAS pain and Tegner scores, respectively. K-means clustering analysis separated the cohort of 82 patients into 2 groups, one with exclusively higher levels of pro-inflammatory biomarkers than the second group. The “pro-inflammatory phenotype” cohort had a significantly higher VAS pain score (p = 0.024) and significantly lower Lysholm (p = 0.022), KOOS-PS (p = 0.047), and Tegner (p = 0.009) scores at the time of final follow-up compared with the “anti-inflammatory phenotype” cohort. The rate of conversion to TKA was higher in the pro-inflammatory cohort (29.4% versus 12.2%, p = 0.064). Logistic regression analysis demonstrated that the pro-inflammatory phenotype was significantly correlated with conversion to TKA (odds ratio = 7.220, 95% confidence interval = 1.028 to 50.720, p = 0.047).

Conclusions:
The concentrations of synovial fluid biomarkers on the day of APM can be used to cluster patients into pro- and anti-inflammatory cohorts that are predictive of PROs and conversion to TKA at long-term follow-up.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Sostenibilidad y Destinos Turísticos Inteligentes: un análisis bibliométrico.
Authors: RAMÍREZ CRUZ AMANDA KATHERIN , AGUILERA AVILA LIANET , ESCALONA MIRANDA ALEXANDER 
Published: September 2024

El turismo como sector económico depende en gran medida de los recursos territoriales que brindan los destinos; de ahí que se apueste por el desarrollo de productos turísticos más sostenibles. Mientras tanto, los Destinos Turístico Inteligentes se vienen a posicionar como nuevos modelos de gestión para hacer frente a los avances tecnológicos y a un cliente cada vez más “digital”. El objetivo de la presente investigación es analizar la producción científica sobre Sostenibilidad Turística y Destinos Turísticos Inteligentes indexada en la base de datos Scopus e identificar tendencias, brechas y futuras líneas de investigación. Para ello se ha empleado el método de estudio bibliométrico y los softwares Biblioshiny® y VOSviewer®, obteniéndose finalmente un total de 71 investigaciones, de las cuales 42 han sido artículos de revisión que analizan indicadores de productividad por año, autores, países, revistas y palabras claves. Como resultado se ha podido constatar un aumento progresivo del número de investigaciones ciertamente importante en la última década, si bien con una alta dispersión temática y geográfica en la producción científica. Como conclusiones se exponen las aplicaciones teóricas y de gestión de los resultados obtenidos.
Palabras clave: destinos turísticos inteligentes; estudio bibliométrico; Scopus; sostenibilidad
Assessment of flood vulnerability in a coastal metropolitan city for sustainable environmental using Machine Learning methods
Authors: V Nivedita , S Sabarunisha Begum , U Sakthi , V Sellam , C Navaneethan , Sikkandar Mohamed Yacin , T Jayasankar , S Vivek 
Published: September 2024

Abstract

Floods are very destructive natural catastrophes that significantly harm people, the environment, and structures. Due to their dynamic nature, flash flood-prone locations are difficult to predict. We used cutting-edge machine learning algorithms for early flash flood detection to overcome this. To evaluate flood vulnerability in Chennai, Tamil Nadu, India, we employed and evaluated two combined ensemble models: the Artificial Neural Network (ANN) and Random Forest (RF). To put these models into practice, we built a GIS framework out of 280 historical flooding sites and twelve flood-related parameters. Using information gain ratio and multicollinearity diagnostic tests, we evaluated the association between flood occurrences and pertinent factors. Statistical criteria like "Freidman" were used to compare the prediction abilities of ANN and RF models. Both ANN and RF models performed better than expected when simulating flood susceptibility. In order to reduce flood-related hazards and create efficient mitigation plans, state and local authorities, as well as policymakers, will benefit from the study's findings and methodology. Flood susceptibility percentages were 18% very low, 16% low, 13% moderate, 22% high, and 31% extremely very high, according to the research of ANN. While this was going on, RF revealed that the likelihood of flooding was 7% very low, 11% low, 34% moderate, 31% high, and 18% extremely very high. Maintaining a strong drainage system, using regulated building techniques in sensitive regions, setting up early warning systems, creating resilient infrastructure, and educating people are all necessary to reduce floods in Chennai. For resource allocation, disaster response, and readiness exercises, effective coordination between government agencies, non-governmental organizations (NGOs), and local populations is essential. Chennai's resistance to floods depends on a multi-pronged approach that includes infrastructure improvement, pro-active planning, and public awareness.
Application of indocyanine green–human serum albumin complex in fluorescence image-guided laparoscopic anatomical liver resection: study protocol for a randomized controlled trial
Authors: Xie QingYun , Gao Fengwei , Ran Xiaoyun , Zhao Xin , Yang Manyu , Jiang Kangyi , Mao Tianyang , Yang Jiayin , Li Kun , Wu Hong 
Published: September 2024

Abstract

Background
Indocyanine green (ICG) is a near-infrared fluorescent dye widely used for intraoperative navigation during liver surgeries because of its non-radioactive nature, high safety, and minimal impact on liver function. However, variability in its dosage and concentration and its low imaging success rates have limited its widespread application. To address these issues, we developed a novel ICG–human serum albumin (ICG-HSA) complex to enhance fluorescence visualization during laparoscopic anatomical liver resection.
Methods
This prospective, double-blind, single-center, randomized controlled trial will compare the fluorescence navigation effects of the novel ICG-HSA complex with the guideline-recommended ICG administration scheme. The study will involve patients aged 18 to 75 years with malignant liver tumors. The participants will undergo evaluations at specified time points, and data will be collected using an internet-based electronic data capture system. The primary outcome will be the effectiveness of intraoperative fluorescence imaging, assessed by three independent experts. The secondary outcomes will be conversion to open surgery, the total operative time, intraoperative blood loss, and long-term survival rates.
Discussion
The aim of using this novel ICG-HSA complex will be to improve the success rate of fluorescence navigation in liver resection by ensuring better stability and a longer liver retention time compared with free ICG. This study seeks to validate the clinical value of ICG-HSA in enhancing surgical precision and outcomes, ultimately promoting its broader clinical application. The results are expected to provide high-level evidence supporting the safety and efficacy of this new fluorescence imaging agent.
Trial registration
Clinicaltrial.gov, NCT06219096. Registered on 1 December 2024.
Numerical investigation of miniature vortex generators on an airfoil
Authors: Szabó András , Nagy Péter Tamás , Kulcsár Márton , de Baets Gilles , Vanierschot Maarten , Paál György 
Published: September 2024

Abstract

Miniature vortex generators (MVGs) have a large potential to reduce the friction drag by delaying laminar–turbulent transition in boundary layer flows with attenuating the growth of the Tollmien–Schlichting (TS) waves. This study is concerned with the modal stability analysis of the streamwise elongated streaks in the boundary layer on the suction side of an aerodynamic body — the Bluepoint solar car of the Innoptus solar team. Two MVG configurations are investigated: one that was the focus of previous experimental studies and another one that is the recommendation of Szabó et al. (Computers & Fluids, 269, 106123, 2024). Using the methodology of Szabó et al., the stationary flow is calculated with three–dimensional CFD simulation and the boundary region equations, while the modal stability of the flow is modeled using BiGlobal and parabolized stability equations. It is shown that because of the low curvature, in the base flow calculation, curvature effects can be accounted for by incorporating the pressure gradient in the modeling equations. Furthermore, the curvature can also be neglected in the stability calculations, while non–local effects have a more substantial influence on the stability of the flow. Finally, it is shown that in the case of the streamlined body, the recommendations of Szabó et al. derived in the flat-plate boundary layer are not superior, which reveals the need for further research efforts.
Are fibrous cortical defect (FCD) and non-ossifying fibroma (NOF) only a radiological finding? Relationship between radiological/clinical findings and physical activity in children and adolescents: A cross-sectional study
Authors: Berk Erhan , Baykara Rabia Aydogan 
Published: September 2024

Abstract

Background: Fibrous cortical defect (FCD) and non-ossifying fibroma (NOF) are incidentally recognised and benign developmental lesions. The objective of this study was to ascertain the clinical manifestations and symptoms of FCD/NOF in children and adolescent patients, to characterise the lesions radiologically using X-ray and MRI techniques, and to determine the relationship between physical activity and the condition.
Materials and Methods: The study included patients under the age of 18 with radiological lesions on their extremities. The lesions were classified as FKD or NOF in accordance with the distinctive imaging features. For each lesion, the bone involved, the site involved, the size of the lesion, and the type of lesion according to the Ritschl classification were recorded. In the anamnesis, the patient's presenting complaint, the character of the pain, if any, and the level of activity were investigated. Pain was quantified using the visual analogue scale (VAS) and the 21-Numbered Circle VAS.(21-NCVAS) The 21-Numbered Circle Activity Scale(21-NCAS) and the International Physical Activity Questionnaire (IPAQ) were employed for the assessment of physical activity.
Results: 34 lesions in 28 children (14 girls/14 boys) were included in the study. Age was not different between girls and boys (p = 0.45). According to Ritschl classification, 18 (52.9%) lesions were stage A, 9 (26.5%) were stage B and 7 (20.6%) were stage C. The lesion size increased with increasing Ritschl stage (p<0.02). The main presenting complaint was pain (n = 13, 49.9%). In 21.4% of the children (n=6), lesions were detected incidentally on radiographs. According to IPAQ, 39.3% of the children were physically inactive. There was a significant negative correlation between 21-NCAS and Ritschls stage (r= -.51, p<.05). Activity decreased as the Ritschl stage increased. There was a significant negative correlation between 21-NCAS and VAS (r=-.69, p<.05).
Conclusion: Spontaneous pain was observed in 49.9% of patients diagnosed with FCD/NOF. No correlation was identified between lesion size and the presence or severity of pain. As the severity of pain and Ritschl stage increased, there was a corresponding decrease in physical activity.
The Value of PET/CT Radiomics for Predicting Survival Outcomes in Patients with Pancreatic Ductal Adenocarcinoma
Authors: Kang Yeon-koo , Ha Seunggyun , Jeong Ji Bong , Oh So Won 
Published: September 2024

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis even without distant metastases, necessitating in-depth characterization of primary tumours for survival prediction. We assessed the feasibility of using FDG-PET/CT radiomics to predict overall survival (OS) in PDAC. This retrospective study included PDAC patients without distant metastasis who underwent FDG-PET/CT for initial staging. Primary tumours were segmented from FDG-PET/CT images, extracting 222 radiomics features. A radiomics-based risk score (Rad-score) was developed using Cox proportional hazards regression with LASSO to predict OS. The prognostic performance of the Rad-score was compared with a clinical model (demographics, disease stage, laboratory results) using Harrell's concordance index (C-index) and bootstrapping. 140 patients were included, with a mortality rate was 72.9% during follow-up (total population, 19.5 ± 19.2 months; survivors, 34.4 ± 28.8 months). Eleven radiomics features were significant for survival prediction. The Rad-score predicted OS with a C-index of 0.681 [95% CI, 0.632–0.731]. A model integrating clinical parameters and Rad-score outperformed the clinical-only model in predicting OS (C-index 0.736 [0.727–0.812] vs. 0.667 [0.648–0.750]; C-index difference 0.069 [0.028–0.117]; P < 0.001). These findings suggest that incorporating FDG-PET/CT radiomics into preexisting prognotic stratification paradiagm may enhance survival prediction in PDAC, warranting large-scale studies to confirm its applicability in clinical practice.
The impact of Insulin Resistance evaluated by 20/ (fasting blood glucose × fasting C-peptide) on cognitive declined Japanese Type 2 Diabetes Patient
Authors: Nonaka Takahiro , Kono Kenichi , Ishii Hideaki , Owari Go , Watabe Yuto , Takemoto Minoru , Nishida Yusuke 
Published: September 2024

Abstract

This study investigates the mechanisms by which type 2 diabetes affects brain parenchyma and impairs higher brain functions, focusing on insulin resistance. The analysis included 20 participants with an average age of 72.5 years and an average diabetes duration of 12 years. The study found a significant positive correlation between insulin resistance (CPR-IR) and general cognitive function (MoCA-J), but no significant correlations with executive function (FAB) or attention function (TMT-A and TMT-B). These findings suggest that insulin resistance contributes to cognitive decline in diabetic patients, likely due to impaired insulin signaling in the brain. This study highlights the importance of evaluating and addressing both insulin resistance and secretion capacity in diabetes treatment, particularly for Japanese patients who often have lower insulin secretion. The results underscore the potential benefits of exercise therapy in improving cognitive functions and suggest that designing treatment programs to enhance behavioral modifications could be beneficial for diabetes management. Future research should involve larger sample sizes and more detailed evaluation items to further explore these relationships and improve therapeutic strategies for cognitive decline in diabetic patients.