bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heat shock transcription factor 1 facilitates liver cancer progression by driving super‐enhancer‐mediated transcription of MYCN
Authors: Liu Yizhe , Shi Qili , Su Yue , Chen Zhiao , He Xianghuo 
Published: September 2024

AbstractBackgroundHeat shock transcription factors (HSFs) play crucial roles in the development of malignancies. However, the specific roles of HSFs in hepatocellular carcinoma (HCC) have yet to be fully elucidated.Aims:To explore the involvement of the HSF family, particularly HSF1, in the progression and prognosis of HCC.Materials & MethodsWe conducted a thorough analysis of HSF expression and copy number variations across various cancer datasets. Specifically focusing on HSF1, we examined its expression levels and prognostic implications in HCC. In vitro and in vivo experiments were carried out to evaluate the impact of HSF1 on liver cancer cell proliferation. Additionally, we utilized CUT&Tag, H3K27 acetylation enrichment, and RNA sequencing (RNA‐seq) to investigate the super‐enhancer (SE) regulatory landscapes of HSF1 in liver cancer cell lines.ResultsHSF1 expression is elevated in HCC and is linked to poor prognosis in several datasets. HSF1 stimulates liver cancer cell proliferation both in vitro and in vivo, partly through modulation of H3K27ac levels, influencing enhancer distribution. Mechanistically, our findings demonstrate that HSF1 transcriptionally activates MYCN expression by binding to its promoter and SE elements, thereby promoting liver cancer cell proliferation. Moreover, increased MYCN expression was detected in HCC tumors and correlated with unfavorable patient outcomes.DiscussionOur study sheds light on previously unexplored aspects of HSF1 biology, identifying it as a transcription factor capable of shaping the epigenetic landscape in the context of HCC. Given HSF1's potential as an epigenetic regulator, targeting the HSF1‐MYCN axis could open up new therapeutic possibilities for HCC treatment.ConclusionThe HSF1‐MYCN axis constitutes a transcription‐dependent regulatory mechanism that may function as both a prognostic indicator and a promising therapeutic target in liver cancer. Further exploration of this axis could yield valuable insights into novel treatment strategies for HCC.
Effectiveness of mobile health for exercise promotion on cardiorespiratory fitness after a cancer diagnosis: A systematic review and meta‐analysis
Authors: Gregory Megan E. , Cao Weidan , Rahurkar Saurabh , Haroun Fadi , Stock James C. , Ghazi Sanam M. , Addison Daniel 
Published: September 2024

AbstractBackgroundCancer survivors are at greater risk for cardiovascular‐related mortality. Mobile health (mHealth) is an increasingly prevalent strategy for health promotion, but whether it consistently improves cardiorespiratory outcomes after a cancer diagnosis is unknown. We sought to determine the effectiveness of mHealth fitness/physical activity interventions on cardiorespiratory fitness outcomes among cancer patients and survivors.MethodsLeveraging MEDLINE/PubMed, Scopus, and ClinicalTrials.gov, we identified studies through May 2023. Included studies provided a quantitative evaluation of an mHealth intervention in a primary or secondary capacity on cardiorespiratory fitness (6‐minute walk test, VO2max, 3‐minute step test, or systolic blood pressure; or any mention of cardiac measure) and were meta‐analyzed (using a random effects model) if they were a randomized controlled trial with sufficient quantitative information. Four coders were involved in applying inclusion/exclusion criteria, coding using a standardized data extraction sheet, and assessing study quality, with each study coded by at least two.ResultsOf 656 articles, nine (n = 392) met systematic review inclusion criteria (mean age range 19–62 years, 71.9% female, 60.9% breast cancer). Interventions included mobile apps (k = 6), smartwatches (k = 2), or a smartwatch plus a supplemental web/mobile/tablet app (k = 1); median duration of mHealth‐use was 12 weeks. Seven (n = 341) fit criteria for meta‐analysis. mHealth was associated with improved cardiorespiratory fitness (d = 0.33; 95% CI = 0.07–0.60) compared to a control group. Relationships remained after accounting for lipid‐based outcomes (d = 0.30; 95% CI = 0.03–0.56). There was no evidence for heterogeneity or publication‐bias.ConclusionsmHealth exercise interventions appear to be a viable strategy for improving cardiorespiratory fitness after a cancer diagnosis.
A Synergistic Interaction Between Citrus Hystrix Peel Essential Oil and Tetracycline and Evaluation of their Antibacterial Mechanism of Action in Vitro and in Silico Against Escherichia Coli
Authors: Aini Khairunnisa Nur , Yuandani  , Raina Nasution Halimah , Sari Utami Dinda , Frimayanti Neni , Jantan Ibrahim , Nirmal Nilesh , Wira Septama Abdi 
Published: September 2024

AbstractCitrus hystrix essential oil (CHEO) have shown various pharmacological properties including antibacterial activity. This EO also possessed antibacterial effect against foodborne pathogens. There is less information available about the synergy interaction between CHEO and tetracycline, as well as their mechanism of action. Therefore, this study was conducted to evaluate the synergistic effect of CHEO and tetracycline against clinical isolate of Escherichia coli. Antibiofilm, bacteriolytic, and efflux pump inhibitor activities were also performed. The chemical composition of CHEO was analysed using GC‐MS. Three major compounds, D‐limonene (25.02 %), β‐pinene (23.37 %), and β‐sabinene (22.20 %) were identified. CHEO exhibited moderate antibacterial activity with MIC value of 250 μg/mL. The combination of CHEO (7.8 μg/mL) and tetracycline (62.5 μg/mL) produced a synergistic effect on E. coli with fractional inhibitory concentration index of 0.5. This mixture inhibited biofilm formation in E. coli. The combination of 7.8 μg/mL CHEO and 62.5 μg/mL tetracycline demonstrated bacteriolytic activity. In addition, the CHEO at 250 μg/mL showed a significant effect in inhibiting efflux pump. D‐limonene has a binding free energy value of −20.13 kcal/mol with ompA transmembrane domain of E. coli. This finding indicates that CHEO has a potency to be developed as natural antibacterial against E. coli.
Pestiorosins A–F, New Papulacandins Isolated from the Fungus Pestalotiopsis rosea YNJ21
Authors: Lu Yue , Duan Ming‐Hua , Zhao Xue , Zhang Yang , Yang Yu , Xu Rui , Kang Ya‐Shuai , Wang Zi‐Lin , Zhang You‐Zhi , Li Chang‐Wei 
Published: September 2024

AbstractSix previously unreported papulacandins, namely pestiorosins A–F (1–6), were isolated from the fermentation products of the fungus Pestalotiopsis rosea YNJ21 isolated from the fruitbody of Amanita exitialis. The structures of these compounds, along with a known compound called pestiocandin (7), were determined using MS, NMR data, and modified Mosher's method. All compounds exhibited significant antifungal activity against Candida albicans, with MIC values ranging from 0.06 to 2.00 μg/mL. In terms of cytotoxicity assays, compounds 3 and 6 demonstrated moderate inhibitory activity against human breast cancer MCF‐7 cells with IC50 values of 24.50 and 16.83 μM, respectively. On the other hand, compound 7 displayed similar levels of inhibitory activity against mice microglial BV2 cells with an IC50 value of 24.51 μM.
Achieving Complete Conversion from Nickel Foam to Nickel Sulfide Foam for a Freestanding Hybrid‐Supercapacitor Electrode
Authors: Yi Xuerui , Kirk Caroline , Robertson Neil 
Published: September 2024

AbstractWe present a unique, one‐step, hydrothermal process to prepare nickel sulfide (Ni3S2) foam by a simple and direct conversion from nickel foam, which contributes both as a scaffold for the reaction and as reactant. The Ni3S2 foam exhibits remarkable mechanical stability, retaining the structural integrity of the foam and excellent crystallinity even after ultrasonication at 200 W for 30 mins. We document the transformation of the nickel foam template into a Ni3S2 foam, highlighting the role of synthesis duration on the phase evolution and unique morphology of Ni3S2. PXRD and SEM analyses reveal a complete transformation after 24 hours from the nickel foam to a pure Ni3S2 foam, which has a highly porous and interconnected ultra‐thin nanosheet architecture. This significantly enhances the surface area and provides many electrochemical reaction sites. In a three‐electrode cell, the capacity of the Ni3S2 foam electrode is 3.9 C cm−2 at 8 mA cm−2, which is higher than previous reports for Ni3S2. In a hybrid supercapacitor device, the Ni3S2 foam demonstrates significant increase in capacitance through 500 cycles and the capacitance plateaus after 2000 cycles. Even after 8500 continued charge‐discharge cycles, the device exhibits excellent cycle stability indicating improvement with age.
Controlling the Helical Pitch of Foldamers through Terminal Functionality: A Solid State Study
Authors: Davis Alexander R. , Ozturk Sena , Seaton Colin C. , Male Louise , Pike Sarah J. 
Published: September 2024

AbstractDeveloping new methods to control the size and shape of the helical structures adopted by foldamers is highly important as the secondary structure displayed by these supramolecular scaffolds often dictates their activity and function. Herein, we report on a systematic study demonstrating that the helical pitch of ortho‐azobenzene/2,6‐pyridyldicarboxamide foldamers can be readily controlled through the nature of the terminal functionality. Remarkably, simply through varying the end group of the foldamer, and without modifying any other structural features of the scaffold, the helical pitch can be over doubled in magnitude (from 3.4 Å–7.3 Å). Additionally, crystallographic analysis of a library ten foldamers has identified general trends in the influence of a range of terminal functionalities, including carboxylbenzyl (Cbz), diphenylcarbamyl (N(Ph)2), ferrocene (Fc) and tert‐butyloxycarbonyl (Boc), in controlling the folding behaviour of these supramolecular scaffolds. These studies could prove useful in the future development of functional foldamers which adopt specific sizes and shapes.
Post‐Synthetic Modification of a 1D Mixed‐Linker Zn(II) Coordination Polymer for Acid‐Catalyzed Alcoholysis of Epoxides
Authors: Najafi Mahnaz , Janczak Jan 
Published: September 2024

AbstractRational design of heterogeneous acid catalysts possessing uniform dispersion of active sites plays a significant role in the catalytic performance. In the present work, a coordination polymer, [Zn(4,4'‐bpy)(μ‐Hbtc)(H2O)] ⋅ 2H2O (Zn‐CP), was solvothermally synthesized using 4,4'‐bpy (=4,4'‐bipyridine) and H3btc (=1,3,5‐benzenetricarboxylic acid) mixed linkers. Single crystal X‐ray analysis of the polymer displayed that Zn‐CP chains were decorated with 4,4'‐bpy having unidentate coordination fashion. Then, the free N atom of the linker in Zn‐CP was functionalized by ‐SO3H groups to afford Zn‐CP‐SO3H with enhanced acidity. The structures were characterized by FT‐IR, thermogravimetric analysis, powder X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), temperature programmed desorption of NH3 (NH3‐TPD), and field emission scanning electron microscopy (FE‐SEM) analyses. The coordination polymer was employed as a heterogeneous catalyst for the alcoholysis of epoxides under room conditions. Zn‐CP‐SO3H exhibited excellent catalytic activity and regioselectivity in the methanolysis of styrene oxide within short reaction time.
A Zero‐Voltage Switching Three‐Level Nonisolated Bidirectional DC/DC Converter With a Lossless Passive Component Auxiliary Circuit and Design‐Oriented Analysis
Authors: Liang Yingbao , Xie Fan , Liu Yanlin , Zhang Bo , Qiu Dongyuan 
Published: September 2024

ABSTRACTA three‐level bidirectional buck/boost converter (TLBBBC) is suitable for power electronic systems with a high‐voltage DC link for its switches with half voltage. In order to achieve higher efficiency, a novel zero‐voltage switching (ZVS) TLBBBC is proposed in this paper to enable operation with higher switching frequencies. In the proposed ZVS TLBBBC, two identical ZVS cells, each composed of a resonant inductor, two snubber capacitors, and two resonant capacitors, are integrated with the conventional three‐level (TL) topology to enable soft switching in all four switches in both buck and boost modes. Here, one advantage is that soft‐switching conditions are ensured under conventional control methods without using the auxiliary switch or complex control methods. In addition, the soft‐switching region is derived, clearly illustrating the relationship between the duty cycle ratio and the power inductor current that ensures the soft‐switching condition. Hence, the soft‐switching region is beneficial for assisting in ZVS cell design and guiding the converter in running in ZVS. Then, the operation and design considerations of the proposed topology are analyzed in detail. Finally, the experimental results of an 800‐W prototype for both the boost and buck modes are presented to confirm the theoretical analysis.
Deployment options of AI components for network resource management in 5G‐enabled agile industrial production cell
Authors: Szabó Géza , Pető József , Vidács Attila 
Published: September 2024

SummaryOn‐demand manufacturing in Industry 4.0 requires flexibility of the networks which can be provided with the fifth generation (5G) of mobile communications wireless connectivity. A key component in the efficient utilization of the radio resources in a manufacturing scenario is network resource management (NRM). We show how NRM can be automated with artificial intelligence (AI). We introduce several futuristic industrial use cases that require AI in various parts of the process. We analyze the AI components' benefits and disadvantages in several deployment scenarios. The findings can be used by business stakeholders interested in deploying the 5G cellular wireless network to choose the best NRM and AI implementation strategy for a particular use case. We show that there are many viable options for the AI component in the process automation, but the cost of AI has to be considered in all cases. Also, we point out that an essential component, the standardized information flow on the status of the productivity key performance indicators (KPIs), is needed for the successful deployment and application of the 5G AI.
MicroRNA‐146a deficiency enhances host protection against murine cytomegalovirus
Authors: Wong Pamela , Leong Jeffrey W. , Sohn Hyogon , Chang Lily , Keppel Catherine R. , Neal Carly C. , Cubitt Celia C. , Yao Tony , Keppel Molly P. , Tran Jennifer , Burdi Allison , Hwang Kimberly , Fogel Leslie A. , Schappe Timothy , Marsala Lynne , Berrien‐Elliott Melissa M. , Wagner Julia A. , Schneider Stephanie E. , Sullivan Ryan P. , Pingel Jeanette T. , Cooper Megan A. , French Anthony R. , Fehniger Todd A. 
Published: September 2024

AbstractNatural killer (NK) cells are innate lymphoid cells that protect a host from viral infections and malignancies. MicroRNA‐146a (miR‐146a) is an important regulator of immune function that is highly expressed in NK cells and is further upregulated during murine cytomegalovirus (MCMV) infection. Here we utilized mice with a global targeted deletion of miR‐146a to understand its impact on the innate immune responses to MCMV infection. MiR‐146a−/− mice were protected from lethal MCMV infection, which was intrinsic to the hematopoietic compartment based on bone marrow chimera experiments. NK cell depletion abrogated this protection, implicating NK cells as critical for the miR‐146a−/− protection from MCMV. Surprisingly, NK cells from miR‐146a‐deficient mice were largely similar to control NK cells with respect to development, maturation, trafficking, and effector functions. However, miR‐146a−/− mice had increased NK cell numbers and frequency of the most mature Stage IV (CD27−CD11b+) NK cells in the liver at baseline, enhanced STAT1 phosphorylation, and increased selective expansion of Ly49H+ NK cells and T cells during MCMV infection. This study demonstrates a critical role for miR‐146a in the host response to MCMV, arising from mechanisms that include increased NK cell numbers and early T‐cell expansion.
Complex formation and stabilization of Z‐isomer‐enriched astaxanthin esters derived from Haematococcus lacustris with water‐soluble carriers via spray drying
Authors: Sakaguchi Rina , Ghosh Antara , Banik Sujan , Nishida Yasuhiro , Honda Masaki 
Published: September 2024

AbstractTo enhance the water solubility and bioavailability of astaxanthin esters, inclusion complexes of Z‐isomer‐enriched astaxanthin esters with water‐soluble carriers were prepared using a spray drying technique. A food‐grade Haematococcus alga extract was used as the source of astaxanthin esters, and the Z‐isomerization was performed via direct heating of the extract. Polyvinylpyrrolidone (PVP) and hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) were used as water‐soluble carriers. The effects of spray drying conditions on the encapsulation efficiency of astaxanthin esters in the carriers and the total Z‐isomer ratio of encapsulated astaxanthin esters were investigated, and the physical properties and storage stability of the resulting composites were evaluated. Under optimum spray drying conditions, efficient production of highly water‐soluble Z‐isomer‐rich astaxanthin esters was achieved in both carriers: >95% encapsulation efficiency and >55% total Z‐isomer ratio. The physical properties, such as surface morphology and particle size distributions, of the resulting particles differed significantly between PVP and HP‐β‐CD. Storage tests demonstrated that the formulated Z‐isomer‐rich astaxanthin esters were highly stable. Our findings will contribute to the practical applications of Z‐isomer‐rich astaxanthin materials.Practical Applications: The formulation technology developed in this study has the potential to address the industrial challenges of using astaxanthin, that is, low water solubility and low bioavailability. Furthermore, the low storage stability of astaxanthin Z‐isomers, which hinders their industrial use, can be solved simultaneously. The resulting Z‐isomer‐rich astaxanthin powders are expected to be used in a wide range of applications, including nutraceuticals, cosmetics, and animal feeds.
A preformulation study of marine alkaloid aaptamine: Physicochemical properties investigation and liposomal formulation development toward hepatocellular carcinoma treatment
Authors: Geng Tianjiao , Xue Haitao , Kong Can , He Luping , Wang Shuping , Ding Ling , Zou Xiaoyan , Gu Zhichun , Liao Hongze , Lin Houwen 
Published: September 2024

AbstractHepatocellular carcinoma (HCC) is a global health concern with high prevalence and mortality. A marine alkaloid, AP‐427, has been reported to show potential for HCC treatment. However, its use is limited by low solubility and high toxicity. We aimed to investigate the preformulation parameters and develop AP‐427 liposomes to improve its clinical suitability. A stability‐indicating HPLC assay was established, and the physicochemical properties of AP‐427 were analyzed. Afterward, AP‐427 liposomes were prepared and characterized, and their cytotoxicity was evaluated. AP‐427 had a low solubility at physiological pH, a LogD of 2.56 ± 0.03, and a basic pKa of 3.24 ± 0.12. An entrapment efficiency of 52.71 ± 3.2% was achieved after optimization. The resulting AP‐427 liposomes were 147.2 ± 3.4 nm and stable up to three months when stored in a pellet form at 4°C. The crystallization of AP‐427 in liposomes became less ordered, and AP‐427 liposomes exhibited a controlled release fitted in Korsmeyer–Peppas model, indicating the release was driven by diffusion. Furthermore, AP‐427 liposomes showed a 3.6 times reduced cytotoxicity against HepG2 cells compared with free AP‐427, potentially enhancing its antitumor efficacy. In conclusion, the precise preformulation parameters advanced the AP‐427 liposomal formulation development, which showed potential for HCC treatment.Practical Applications: The aaptamine derivative AP‐427 has shown cytotoxic effects against hepatocellular carcinoma. However, the low solubility and high toxicity limit its clinical application. The present study aims to prepare liposomal formulation to solve the current problems. Results obtained from this study shed light on challenges related to drug solubility and have paved the way for the development of an effective AP‐427 liposomal formulation with promising application in hepatocellular carcinoma therapy.
Directional aspects of crop yield correlation: Implications for insurance rating and contract design
Authors: Goodwin Barry K. , Rejesus Roderick , Harri Ardian , Coble Keith 
Published: September 2024

AbstractWe estimate directional anisotropic models of linear correlation for crop yields. We find that directional distances (i.e., the degree to which yield correlation decays depending on direction) tend to differ from one another, with east to west distances being “longer” than north to south distances (i.e., correlation tends to decline slower in the east to west direction), at least for the major crops of corn and soybeans. Results for wheat are somewhat ambiguous. However, in all cases, average yield aggregates made up of east to west linked counties tend to be more accurate than is the case for north to south linkages. Implications for rating and contract design in the US area yield federal crop insurance program are offered.
The significance of feeling needed and useful to family and friends for psychological well‐being during adolescence
Authors: Fuligni Andrew J. , Trimble Ava , Smola Xochitl Arlene 
Published: September 2024

AbstractIntroductionSocial relationships offer the opportunity to provide support and resources to others. Feeling needed and useful to others has been understudied during adolescence, despite being shown to predict health and well‐being during adulthood. The current study examined this underappreciated way in which family and peer relationships may shape psychological well‐being during adolescence.MethodA cross‐sectional sample of high school students across the United States completed an on‐line questionnaire during school hours in the fall of 2020. The sample consisted of 1301 adolescents averaging 15.94 (SD = 1.24) years in age in the ninth through twelfth grades, with 48.4% identifying as female, 47.3% as male, and 3.2% reporting either other gender identities or preferring not to answer (1%). Participants identified as Hispanic or Latino (40.2%), European American (19.8%), African American (14.7%), Multiethnic (9.2%), Asian American (7%), Other Ethnicities (7.8%), and 1.3% did not report their ethnicity.ResultsFeeling needed and useful was predicted by both helping and receiving support from others, strongly predicted better psychological well‐being, and mediated associations of helping and receiving support with well‐being. Males reported feeling more needed by their family as compared to females, and both reported higher levels of being useful to their family than those with other gender identifications.ConclusionsLike adults, adolescents have a need to contribute and feel needed in their social worlds. Studies of close relationships should incorporate the ways in which youth provide resources and support to others in their lives as well as the sense of feeling needed and useful derived from those activities.