bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring low‐ and high‐order functional connectivity in chronic ankle instability through resting‐state fMRI
Authors: Li Yajie , Wang Zhifeng , Yang Yang , Deng Yan , Shen Yiyuan , Wang Xu , Wang Weiwei , Liu Hanqiu 
Published: October 2024

AbstractBackgroundThe functional connectivity (FC) has emerged as a valuable tool for comprehending the cerebral operational mechanism. Understanding the FC changes in patients with chronic ankle instability (CAI) helps reveal the underlying central nervous system mechanisms of the disease and provides clues for developing personalized treatment plans.ObjectivesTo explore differences between low‐ and high‐order FC in patients with CAI and healthy controls, as well as the correlation among the feature connections and clinical data.MethodsIn our study, we recruited 40 patients with CAI and 42 healthy individuals who had not experienced ankle injuries. All participants underwent clinical assessments of ankle joints, collected the number of ankle sprains within the past 6 months, and performed resting‐state functional magnetic resonance imaging (rs‐fMRI) scans. Pearson correlation and matrix variate normal distribution (MVND) were used to construct low‐order and high‐order FC networks, respectively. Feature selections between groups were performed by two‐sample t‐tests, and a multi‐kernel support vector machine (MK‐SVM) was subsequently applied to combine the multiple connection patterns for the classification. Using leave‐one‐out cross‐validation (LOOCV) to assess classification performance and identify the consensus connections contributing most to classification.ResultsFC was reduced in certain brain regions of CAI patients. More consensus connections were recognized in low‐order FC network than in high‐order FC network. The highest classification accuracy of 91.30% was achieved by combining three connection patterns. The most discriminating functional connections were primarily centered on the default mode network and spanned the visual network, sensorimotor network, ventral attention network, and central executive network. In addition, FC strength in the left cingulate and paracingulate gyrus (DCG.L) and right superior temporal gyrus (STG.R) was negatively correlated with the number of ankle sprains in the past 6 months in all FC networks (p < 0.05).ConclusionsAbnormalities in connectivity in patients with CAI were observed in both low‐ and high‐order FC networks. The adaptive changes in the brain related to CAI may extend beyond the sensorimotor networks, primarily involving higher‐level default mode networks associated with attention. Moreover, the FC strength between DCG.L and STG.R may predict the risk of ankle re‐sprains and help clinicians develop personalized treatment plans.
Outcome of childhood ALK‐positive anaplastic large cell lymphoma relapses: Real‐life experience of the French Society of Pediatric Oncology (SFCE) cohort of 75 French children
Authors: Pereira Victor , Barthoulot Maël , Aladjidi Nathalie , Contet Audrey , Dalle Jean‐Hugues , Dourthe Marie Émilie , Garnier Nathalie , Bruno Bénédicte , Leruste Amaury , Pellier Isabelle , Simonin Matthieu , Paillard Catherine , Verschuur Arnauld , Ducassou Stéphane , Lamant Laurence , Brugieres Laurence , Deley Marie‐Cécile Le , Rigaud Charlotte 
Published: October 2024

AbstractObjectiveTo describe treatments and outcomes of French children treated for relapsed/refractory anaplastic lymphoma kinase‐positive anaplastic large cell lymphoma (ALK+ ALCL).MethodsWe conducted the analysis of a series of 75 French children treated for a first relapsed/refractory ALK+ ALCL between 1999 and 2017.ResultsThe median time to first relapse was 8.1 months from initial diagnosis (2.9 after end of treatment), with 12 relapses during frontline treatment or within 1 month of the end of treatment. Treatment of the first relapse varied according to the period of time and risk factors: 48 received multiagent chemotherapy, including 21 and 19 consolidated with allogeneic stem cell transplantation (SCT) and autologous‐SCT, respectively. Twenty‐one patients received weekly vinblastine, and six received ALK inhibitors (ALKi). Overall, 64/75 patients reached a second complete remission (CR2). Eight out of 11 patients who did not reach CR2 died and the other three were rescued with ALKi, vinblastine, and nivolumab. With a median follow‐up of 8.2 years, 60 patients are alive, 43 in CR2, 15 in CR3, two in CR4; and 15 patients died, six from toxicity and nine from disease progression. The 5‐year event‐free survival and overall survival after first relapse were 51.7% (95% confidence interval [CI]: 39.6%–62.6%) and 80.7% (95% CI: 69.6%–88.1%), respectively. Time to relapse greater than 12 months from initial diagnosis was proven to be a prognostic factor in relapsed/refractory ALK+ ALCL.ConclusionIn relapsed ALK+ ALCL, high survival rate can be reached with various therapeutic strategies. The main challenge remains to prevent subsequent relapses, and to lower long‐term morbidity.
Nanocellulose‐polypropylene composites with novel antimicrobial complex salt
Authors: Zielińska Daria , Wyrwas Bogdan , Ławniczak Łukasz , Borysiak Sławomir 
Published: October 2024

AbstractPolypropylene composites with different contents of zinc‐ammonium salts (3, 5 and 7 wt%) and nanocellulose (1 wt%) after enzymatic bioconversion were characterized by structural, dispersion‐morphological, thermal, antimicrobial and mechanical analysis. It was shown that the use of a newly synthesized salt significantly affected the formation of the supermolecular structure of the polymer matrix and increased the nucleation activity, thermostability and flexibility of the composite materials. Moreover, the addition of the inorganic filler allowed to obtain composites with very good antimicrobial properties against Staphylococcus aureus, Escherichia coli and Candida albicans. An interesting relationship between the degree of filler dispersion in the polymer matrix and the formation of polymorphic varieties was elucidated in the study, which contributes to the improvement of final performance characteristics of composite materials. It is noteworthy that a hybrid filler in the form of nanometric cellulose and a biocidal additive containing zinc‐ammonium complex salt was used for the first time. Research has shown that such polymer composites can find application during the manufacture of smart packaging materials with enhanced barrier properties against oxygen and water vapor as well as improved biocidal characteristics, which will notably extend food storage time. At the same time, the presented process of obtaining the innovative composite materials is an excellent example of sustainable technologies for the design of antimicrobial treatments, while guaranteeing the possibility of further processing of these composite materials through material recycling.Highlights
Zinc‐ammonium complex with antimicrobial properties was obtained
The strength properties and thermal stability of the composites were improved
Degree of filler dispersion in polymer affects formation of polymorphic varieties
The composites can be applied in the production of smart packaging materials
High‐performance triboelectric nanogenerators boosted by synergistically aligned piezoelectric/conductive composite nanofibers
Authors: Yan Jing , Zhang Xiaojing , Zhu Ning , Qin Yuebin , Yang Guang 
Published: October 2024

AbstractTo address the need for efficient, flexible, and wearable power sources for portable electronics, a high performance triboelectric nanogenerator (TENG) was proposed by incorporating vertically‐aligned barium titanate (BaTiO3)/antimony tin oxide (ATO) nanofibers in polydimethylsiloxane (PDMS) negative triboelectric layer, where BaTiO3 served as piezoelectric material, and ATO served as conductive filler. Silver‐coated conductive fabric was used as electrode to ensure integrability and wearability. By strategically coupling the triboelectric effect of PDMS, the piezoelectric effect of BaTiO3 nanofibers, and the charge transfer effect of ATO nanofibers, the TENG exhibited the optimum output voltage and current of approximately 119 V and 28 μA, and power density of 11.74 μW/cm2, respectively. This device demonstrates its potential applications in energy supply by effectively illuminating 174 commercial green LEDs and charging capacitors for powering electronics. Additionally, the successful integration of the TENG into a smart fencing jacket highlights its utility in practical applications.Highlights
TENGs with vertically‐aligned BaTiO3/ATO composite nanofibers was constructed.
The output performance of TENGs were enhanced by coupling triboelectric and piezoelectric effects.
Conductive ATO nanofibers were incorporated to enhance charge transfer for performance enhancement.
A smart fencing jacket with scoring system was developed using the wearable TENG.
Ultrasound visualization of Botulinum toxin injection: Identifying clinical correlates to optimize outcomes in spasticity management
Authors: Harris Kristen A. , Jou Stacey , Kasselman Lora , Escaldi Steven V. 
Published: October 2024

AbstractBackgroundBotulinum toxin injections are well established and commonly used for spasticity management. Clinicians strive to optimize outcomes from toxin injections. One potential complication is toxin spread beyond the intended muscle, which can lead to unwanted weakness. The utilization of ultrasound allows direct visualization of target muscles and identification of toxin leakage from the target muscle. Ultrasound evaluation of clinical factors that correlate to toxin leakage have not been studied.ObjectiveTo identify cases of botulinum toxin injectate leak beyond the targeted muscle during ultrasound‐guided spasticity injections and associate cases of leak with predictive clinical factors, which include muscle size, fibroadipose changes, and number of previous injections.DesignThis was a prospective observational study.SettingAn outpatient clinic in an academic medical center.PatientsPatients who demonstrated wrist flexor spasticity warranting intervention were invited to participate.InterventionsPatients received standard‐of‐care spasticity management with injection of onabotulinumtoxinA into the flexor carpi radialis muscle based upon clinical presentation and prescribing guidelines. Ultrasound video was recorded, and a blinded review was conducted by the study team.Main Outcome MeasuresThe primary outcome measure was visualized leak of injectate on recorded ultrasound video. Documented leak was then associated with clinical factors including diameter of the flexor carpi radialis, volume of injectate used, history of prior injections, and fibrotic change of the muscle.OutcomesThe study included 54 patients, 77.8% of whom had an underlying diagnosis of cerebrovascular accident. Injectate leak was observed in 18.5% of injections and could not be confirmed in 9.3% of injections. Multivariable analysis demonstrated increased odds of leak with higher Modified Heckmatt Scale score. No statistically significant increase in leak was noted with higher volume of injectate or smaller muscle diameter.ConclusionExtramuscular leak of botulinum toxin injection may be associated with fibroadipose muscle change.
A Modified Reentrant Metamaterial with Equal and Enhanced Orthogonal Elastic Properties
Authors: Wang Tingwei , Jia Meng , Cheng Xiaosheng , Dai Ning 
Published: October 2024

Herein, an improved mechanical metamaterial is proposed, which is derived from the decomposition, rotation, and reassembly of reentrant structures. The structure is parametric, allowing for rapid redesign. The study focuses on the variations in equivalent stiffness and Poisson's ratio of the structure within the linear elastic range when internal rib angle θ changes. First, based on homogenization simulation analyses, it has been verified that this design achieves the tailorable equivalent elastic modulus and Poisson's ratio over a wide range, meanwhile, maintaining equal elastic properties in the orthogonal direction at all times. Second, to reduce future repetitive experiments, an interpolation model is established to expand the design domain. The fitting formula indicates that by modifying θ and relative wall thickness t/L0, the elastic performance of the structures can be tailored. Additionally, the impact of boundary conditions is discussed to minimize experimental costs. Finally, the accuracy of the simulations is validated through uniaxial compression tests.
MALDI versus DESI mass spectrometry imaging of lipids in atherosclerotic plaque
Authors: Slijkhuis Nuria , Towers Mark , Claude Emmanuelle , van Soest Gijs 
Published: October 2024

Mass spectrometry imaging (MSI) is a powerful tool for detecting lipids in tissue sections, with matrix‐assisted laser desorption/ionization (MALDI) and desorption electrospray ionization (DESI) as its key ionization techniques. In this study, we examine how MALDI compares with state‐of‐the‐art DESI ionization in identifying lipids in heterogeneous samples, specifically atherosclerotic plaques. Carotid plaques (n = 4) from patients undergoing endarterectomy were snap‐frozen, stored at −80°C, and then sectioned for MSI analysis and H&E staining. Measurements were conducted using a SYNAPT XS mass spectrometer in positive ion mode, employing MALDI with a 2,5‐dihydroxybenzoic acid (DHB) matrix and DESI with a methanol: water (98:2) (v/v) solvent. Our comparison covered spectral profiles, sensitivity, and image quality generated by these two techniques. We found that both MALDI and DESI are highly suitable techniques for detecting a wide range of lipids in atherosclerotic plaque sections. DESI‐MSI exhibited higher ion counts for most lipid classes than MALDI‐MSI and provided sharper images. MALDI detected larger amounts of ceramide and hexosylceramide species, possibly due to its efficient generation of dehydrated ions. In contrast, DESI showed greater peak intensities of cholesteryl ester and triacylglyceride species than MALDI, consistent with reduced fragmentation. These findings establish the relative merits of DESI and MALDI and demonstrate their complementarity as techniques for lipid research in MSI.
Weak Randomness in Graphons and Theons
Authors: Coregliano Leonardo N. , Malliaris Maryanthe 
Published: October 2024

ABSTRACTCall a hereditary family of graphs strongly persistent if there exists a graphon such that in all subgraphons of , is precisely the class of finite graphs that have positive density in . Our first result is a complete characterization of the hereditary families of graphs that are strongly persistent as precisely those that are closed under substitutions. We call graphons with the self‐similarity property above weakly random. A hereditary family is said to have the weakly random Erdős–Hajnal property () if every graphon that is a limit of graphs in has a weakly random subgraphon. Among families of graphs that are closed under substitutions, we completely characterize the families that belong to as those with “few” prime graphs. We also extend some of the results above to structures in finite relational languages by using the theory of theons.
Synthesis and characterization of aluminum oxide nanoparticles (Al2O3‐NPs) and analysis of their antimicrobial efficacy against selected pathogenic microbes
Authors: Farhat Masuoda , Alarbii Fatma , Fenniche Fares , Khane Yasmina 
Published: October 2024

AbstractThis present paper assesses the chemical synthesis of aluminum oxide nanoparticles (Al2O3‐NPs) using a modified sol–gel process. Aluminum nitrate and citric acid were heated to 180 °C until a gel was produced. After that, the dehydrated amorphous gel was sintered at 800 °C for 2 h. The formation of nano‐sized α‐Al2O3 particles was investigated using several characterized methodologies, encompassing Fourier transform infrared spectroscopy, X‐ray diffraction (XRD), dynamic light scattering, and X‐ray fluorescence (XRF). Then, the antibacterial and antifungal activity of synthesized nanoscale Al2O3 particles against pathogens like Escherichia coli, Staphylococcus aureus, and Trichophyton rubrum has been investigated. The successful synthesis of alumina nanoparticles has been validated by several analytical techniques. Nanoparticles of Al2O3‐NPs with a rhombohedral structure and an average crystallite size of 26 nm were revealed by XRD research. Their zeta potential was −8.65 mV, and their size distribution measured 68.6 nm in diameter. The elemental composition of sample was identified with the use of XRF, which indicates that the Al2O3‐NPs powder is quite pure. Furthermore, the antimicrobial experiment showed that the Al2O3‐NPs exhibited the greatest antibacterial efficacy, S. aureus, E. Coli, and T. rubrum exhibited significant inhibition zones with diameters of 13, and 15 mm, and a high inhibition percentage of 70% when exposed to 100 mg/mL of Al2O3 nanoparticles.
The impact of reservoirs on the soils of adjacent areas: overview of global and local aspects
Authors: Ladyka Maryna , Wu Ruofan 
Published: October 2024

AbstractThis study aims to analyze the impact of reservoirs on the soils of surrounding areas to elucidate potential ecological consequences. To achieve this goal, a territorial analysis of the soil surrounding such reservoirs as the Kyiv, Kaniv, Kremenchuk, and Kakhovka, which constitute the Dnieper Cascade of Reservoirs, was conducted. The study found that the average soil pH changes in reservoirs range from 6.0 to 7.5, while nitrogen and phosphorus content in the soil varies from 0.2% to 1.5% and from 0.1% to 0.5%, respectively. Average changes in the content of humic substances and fulvic acids in the reservoirs range from 1.0 to 3.5 and from 0.2 to 1.5 mg/L, respectively. Furthermore, it was found that the creation of large reservoirs on the Dnieper River is accompanied by significant consequences for shoreline soils. The geomorphological study of the reservoirs within the Dnieper Cascade revealed their diversity in terms of shoreline types. Some have more erodible shores, indicating vulnerability to erosion, as observed in the Kakhovka Reservoir, while others have more neutral shores less susceptible to erosion, such as the Kremenchuk Reservoir. The distribution of humic substances in the reservoirs of the Dnieper Cascade is determined by the hydrological structure and water inflows, with the highest concentrations in the upper regions. Decreased flow velocity in the lower part of the cascade leads to the deposition of humic substances in bottom sediments. The threat to ecological systems is exacerbated by incidents such as the catastrophe at the Kakhovka Hydroelectric Power Station in 2023, which triggered a serious ecological crisis with a wide range of consequences. Consequently, the application of a comprehensive approach to water resource management and environmental protection becomes crucial. This entails meticulous planning of construction, implementation of ecological technologies, and engaging the public in the water resource management process.
Dreams, Remembering, and Remembering Dreams: An Intentionalist, Direct Realist, Acquaintance Account
Authors: Copenhaver Rebecca 
Published: October 2024

AbstractI present a generic version of intentionalism to show that intentionalism is motivated by and consistent with direct realism. I also present a theoretically neutral account of acquaintance as direct awareness. I apply intentionalism and an acquaintance view of memory to two questions. First, do dreams acquaint us with the objects, properties, persons, and events they represent? I argue that they don’t. When dreams represent events from your past, they don’t acquaint you with events, even if the events happened. Second, do memory experiences of dreams of events that really happened acquaint us with those events? I argue that they don’t. The memory experience of an event that you dreamed about can’t renew acquaintance, even if the event happened, because dreams don’t acquaint us with events. When you have a memory experience of having dreamed of an event that happened, it is a memory experience, but not a memory: it is a veridical confabulation.
Sonic Ecology and the Role of Sound Art in Creating a Healthy Urban Environment
Authors: Cobussen Marcel 
Published: October 2024

AbstractThis chapter on “Sonic Ecology and the Role of Sound Art in Creating a Healthy Urban Environment” focuses on the influence sound has on collective health and social well-being in general. This implies that sound will be connected to social, economic, cultural, ecological, political, ethical, and aesthetic issues. Thus, the emphasis is on the positive role sound can play. The idea being developed here is that an important opportunity for improvement can be found in sound’s supportive role in establishing more attentive interactions between human (and non-human) beings and their (sonic) environment.
Adverse Childhood Experiences in Parental History and how they Relate to Subsequent Observed Parent–Child Interaction: A Systematic Review
Authors: Weistra Sabina R. , van Bakel Hedwig J. A. , Mathijssen Jolanda J. P. 
Published: October 2024

Abstract
Background
Adverse childhood experiences (ACEs) in parental history have been associated with higher self-reported rates of negative parenting behaviors and lower self-reported rates of positive parenting behaviors. Further research is needed to explore the association between parental ACEs and the observed parent–child interaction quality. Parent–child interactions are a potential pathway behind the continuity of ACEs across generations.

Objective
This review aimed to expand on existing literature by synthesizing evidence on the associations between parental ACEs and parent–child interactions, assessed through videotaped observations, the gold standard for interaction assessment.

Methods
A systematic literature search conducted in October 2022 in Medline, EMBASE, and PsycInfo identified twenty-four articles. The studies assessed parental childhood adversity and the quality of parent–child interaction across high- and low-risk samples.

Results
In 79% of studies, higher rates of childhood adversity were related to lower quality of observed parent–child interaction. Childhood abuse and neglect were linked to fewer positive and more negative parenting behaviors. Among household challenges, only witnessing family violence negatively impacted interaction quality. In 58% of studies, ACEs directly influenced interaction, while in 21% this effect was mediated by other factors. This pattern held across different sample types.

Conclusions
The evidence suggesting a relationship between parental ACEs and lower quality of parent–child interaction is robust, given the reliability and validity of observational measures. Considering the influence of the quality of parent–child interaction on a child’s development, interventions and prevention programs focusing on parent–child interaction should consider screening for parental ACEs.
Nudging law enforcement: evidence from low priority initiatives
Authors: DeAngelo Gregory , Narender Rainita , Romaniuc Rustam 
Published: October 2024

AbstractThe effect of non-binding guidelines (nudges) on citizens’ compliance with law has been studied theoretically and empirically in behavioral law and economics. Less is known about the impact of non-binding guidelines on the behavior of law enforcement agents and prosecution. Our work fills this gap. We study whether non-binding guidelines affect law enforcement and prosecution practices when the guidelines are not necessarily aligned with legal actors’ preferences. Our empirical analysis focuses on the impact of the adoption of a low priority initiative (LPI) on police and prosecutor behavior in Los Angeles County. Our results suggest that following the introduction of an LPI there is a rise in the number of misdemeanor arrests, but not in the rate that misdemeanor marijuana offenses are dismissed. We conclude that law enforcement preferences have a counterbalancing effect given that police officers may have strong punitive preferences. Prosecutors do not appear to respond to non-binding guidelines as evidenced by no change in the rate of dismissing cases.