bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers to Parent Support for Physical Activity in Appalachia
Authors: Nolan Jill A. , Lilly Christa L. , Leary Janie M. , Meeteer Wesley , Campbell Hugh D. , Dino Geri A. , Cotrell Leslie 
Published: June 2016

Background:Parent support for child physical activity is a consistent predictor of increased childhood activity. Little is known about factors that prevent or facilitate support. The purpose of this research was to identify barriers to parent support for child physical activity in Appalachian parents.Methods:A cross-sectional study assessed parents whose children participated in Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) screenings in a rural Appalachian state. Barriers to parental support for physical activity, demographics, geographic location, and parental support for activity were measured.Results:A total of 475 parents completed surveys. The majority were mothers (86.7%), parents of kindergarteners (49.5%), white (89.3%), and living in a nonrural area (70.5%). Community-level factors were most frequently cited as barriers, particularly those related to the built environment. Rural and low-income parents reported significantly higher barriers. Community, interpersonal, and intrapersonal barriers were negatively correlated with parent support for child physical activity. Parents of girls reported a higher percentage of barriers related to safety.Conclusions:Reported barriers in this sample differed from those reported elsewhere (Davison, 2009). Specific groups such as low-income and rural parents should be targeted in intervention efforts. Future research should explore gender differences in reported barriers to determine the influence of cultural stereotypes.
Parental Perception of Neighborhood Safety and Children’s Physical Activity
Authors: Galaviz Karla I. , Zytnick Deena , Kegler Michelle C. , Cunningham Solveig A. 
Published: June 2016

Background:We examined the relationship between parents’ perception of neighborhood safety and children’s physical activity and use of recreation facilities in a US nationally representative sample of fifth grade children.Methods:We used data from the Early Childhood Longitudinal Study Kindergarten cohort, fifth grade sample (N = 9827). Multivariate logistic and linear regression models were used to examine associations between parents’ perception of neighborhood safety for outside play and number of days children engage in physical activity, as well as children’s use of recreational facilities for physical activity.Results:Children who used recreational facilities engaged in physical activity on more days of the week compared with children who did not use a facility (3.3 days vs. 3.8 days, P < .0001). Children from neighborhoods perceived as unsafe by parents engaged in almost 1 less day per week in physical activity (β = –.89, P < .0001). Children from neighborhoods perceived as unsafe were less likely to use recreational facilities compared with children from neighborhoods perceived as safe (odds ratio = 0.72, P < .0001). Children from less affluent families across rural and urban areas had half the odds of using recreational facilities compared with children from the wealthiest families living in urban areas.Conclusions:Parents’ perception of neighborhood safety for outside play can deter or promote children’s physical activity and use of recreational facilities. Children from less affluent families are less likely to use facilities than children from wealthy families, regardless of place of residence.
Epigenetic balance of gene expression by Polycomb and COMPASS families
Authors: Piunti Andrea , Shilatifard Ali 
Published: June 2016

A balancing act in modifying chromatin
Chromatin modifiers add chemical groups to histones, the proteins that package DNA. These modifications are central to cellular development, and mutations in their molecular machinery are linked to a variety of human diseases. Piunti and Shilatifard review the balance between the prototypic chromatin modifiers Polycomb and COMPASS complexes and their role in gene regulation and normal development. Although originally identified as indispensible regulators of fruit fly development, related roles have been identified in other organisms. Furthermore, mutations in human homologs have been implicated in various cancers. As such, these complexes may serve as effective targets for epigenetic therapies.

Science
, this issue p.
10.1126/science.aad9780
PCR-Based Serotyping of Streptococcus pneumoniae from Culture-Negative Specimens: Novel Primers for Detection of Serotypes within Serogroup 18
Authors: Tanmoy Arif M. , Saha Senjuti , Darmstadt Gary L. , Whitney Cynthia G. , Saha Samir K. 
Published: June 2016

ABSTRACT

Six multiplex-compatible PCR primers were designed to distinguish
Streptococcus pneumoniae
serotypes within serogroup 18 from culturable/nonculturable pneumococcal specimens, with no cross-reactivity with other serotypes and respiratory organisms. These primers will aid in the generation of better data on vaccine/nonvaccine serotypes in invasive and carriage pneumococcal surveillance and contribute to future vaccine formulation and impact studies.
Time-Dependent Rate Phenomenon in Viruses
Authors: Aiewsakun Pakorn , Katzourakis Aris 
Published: June 2016

ABSTRACT
Among the most fundamental questions in viral evolutionary biology are how fast viruses evolve and how evolutionary rates differ among viruses and fluctuate through time. Traditionally, viruses are loosely classed into two groups: slow-evolving DNA viruses and fast-evolving RNA viruses. As viral evolutionary rate estimates become more available, it appears that the rates are negatively correlated with the measurement timescales and that the boundary between the rates of DNA and RNA viruses might not be as clear as previously thought. In this study, we collected 396 viral evolutionary rate estimates across almost all viral genome types and replication strategies, and we examined their rate dynamics. We showed that the time-dependent rate phenomenon exists across multiple levels of viral taxonomy, from the Baltimore classification viral groups to genera. We also showed that, by taking the rate decay dynamics into account, a clear division between the rates of DNA and RNA viruses as well as reverse-transcribing viruses could be recovered. Surprisingly, despite large differences in their biology, our analyses suggested that the rate decay speed is independent of viral types and thus might be useful for better estimation of the evolutionary time scale of any virus. To illustrate this, we used our model to reestimate the evolutionary timescales of extant lentiviruses, which were previously suggested to be very young by standard phylogenetic analyses. Our analyses suggested that these viruses are millions of years old, in agreement with paleovirological evidence, and therefore, for the first time, reconciled molecular analyses of ancient and extant viruses.

IMPORTANCE
This work provides direct evidence that viral evolutionary rate estimates decay with their measurement timescales and that the rate decay speeds do not differ significantly among viruses despite the vast differences in their molecular features. After adjustment for the rate decay dynamics, the division between the rates of double-stranded DNA (dsDNA), single-stranded RNA (ssRNA), and ssDNA/reverse-transcribing viruses could be seen more clearly than before. Our results provide a guideline for further improvement of the molecular clock. As a demonstration of this, we used our model to reestimate the timescales of modern lentiviruses, which were previously thought to be very young, and concluded that they are millions of years old. This result matches the estimate from paleovirological analyses, thus bridging the gap between ancient and extant viral evolutionary studies.
Recent volcanic resurfacing of Venusian craters
Authors: Whitten Jennifer L. , Campbell Bruce A. 
Published: June 2016

Abstract
Ejecta from impact craters on Venus are a major source of fine-grained materials across the planet, and crater spatial distribution has been studied as a guide to the relative age and resurfacing rates of large regions. Of particular interest is the potential intersection of distal crater deposits and tesserae, highly deformed landforms that may be the oldest materials on Venus. The composition of tesserae is unknown, but is key to understanding whether water played a role in crustal differentiation. Thus, tesserae are ideal sites for future landed missions to identify possible felsic materials, but the short lifespan of surface landers means that efforts must be made to avoid contaminating surface materials from craters. Here we develop a method to detect distal crater ejecta on tessera terrain across Venus using NASA Magellan radar data. Our results show that fine-grained ejecta are unevenly distributed in the tesserae with respect to nearby craters. Many tesserae within a few hundred kilometers of plains craters do not have evidence for thick (&gt;5–10 cm) mantling material, indicating that eolian or mass-wasting processes have moved the debris off the highland ridge slopes. At Sudenitsa Tesserae, within the young Beta-Atla-Themis region, we observe a radar signature of mantling debris, but there is no apparent source crater to which this material can be traced. We infer that the source crater has been resurfaced by volcanic activity within the past 80 m.y., and suggest that similar fine-grained ejecta deposits may have built up over time in other tesserae across Venus.
Clinical outcomes of a scapular-focused treatment in patients with subacromial pain syndrome: a systematic review
Authors: Reijneveld Elja A E , Noten Suzie , Michener Lori A , Cools Ann , Struyf Filip 
Published: June 2016

ObjectiveTo systematically review the literature on the clinical outcomes of scapular-focused treatments in participants with subacromial pain syndrome (SPS).DesignSystematic literature review. Studies were appraised by two reviewers using the Physiotherapy Evidence Database (PEDro) scale, and a best-evidence synthesis was performed.Data sourcesThe literature search was conducted in the databases PubMed, Embase and Cinahl up to February 2015.Eligibility criteria for selecting studiesRandomised controlled trials evaluating the clinical outcomes of a physiotherapeutic scapular-focused treatment in participants with SPS.ResultsFour studies were included describing various scapular-focused interventions, including scapular-focused exercise therapy, scapular mobilisation and scapular taping. All included studies had a PEDro score of 6 or higher, indicating low risk of bias. There was moderate evidence that scapular-focused treatment compared with other physiotherapeutic treatment is effective in improving scapular muscle strength in participants with SPS. Conflicting evidence was found for improvements in pain, function and clinical measures of scapular positioning. No evidence was found for improvements in shoulder range of motion or rotator cuff muscle strength.ConclusionsThere is some support for the use of scapular-focused exercise therapy in patients with SPS. Owing to the low number of studies, no firm conclusions can be drawn. Therefore, more randomised controlled trials are needed to determine the clinical outcomes of scapular-focused exercise therapy, scapular mobilisation techniques and scapular taping in patients with SPS.
Current state of concussion prevention strategies: a systematic review and meta-analysis of prospective, controlled studies
Authors: Schneider Daniel K , Grandhi Ravi K , Bansal Purnima , Kuntz George E , Webster Kate E , Logan Kelsey , Barber Foss Kim D , Myer Gregory D 
Published: June 2016

ObjectiveThe aim of the current review was to systematically identify, evaluate and synthesise trials that examine concussion prevention via equipment, educational programmes and training programmes.Data sourcesPubMed and EBSCO host (CINAHL, MEDLINE, SPORTDiscus).Eligibility criteria for selecting studiesThe electronic databases PubMed and EBSCO were searched using the phrases:concussion prevention equipment,concussion prevention trainingandconcussion prevention education. Included studies utilised a prospective study design to evaluate the preventative effect of: (1) equipment, (2) training or (3) educational programmes on the incidence of concussions in comparison to a control group.Data extractionDemographic data and intervention methods were recorded. Intervention and control group concussion rates and superficial head injury rates were extracted and combined using random-effects relative risk meta-analysis.Results14 studies evaluated interventions of novel protective equipment. One prospective investigation evaluated an educational programme. The relative risk of concussion for participants enrolled in the interventional arms of trials was not significantly different from that in standard practice arms (RR=0.78, 95% CI 0.55 to 1.11, χ2=1.8, p=0.17; I2=85.3%, 95% CI 71.5% to 90.8%). The relative risk of concussion for participants wearing protective equipment (ie, headgear, full face shields) relative to their counterparts wearing standard or no equipment, calculated from seven available reports, showed no effect of intervention (RR=0.82, 95% CI 0.56 to 1.20, χ2=1.06, p=0.30; I2=86.7%, 95% CI 73.3% to 91.8%). The relative risk of superficial head injury for participants wearing protective equipment relative to their counterparts, calculated from three reports, showed a significant risk reduction (RR=0.41, 95% CI 0.31 to 0.56, χ2=34.13, p<0.0001; I2=53.1%, 95% CI 0% to 85.2%).ConclusionsProspective controlled studies indicate that certain protective equipment may prevent superficial head injury, but these items are suboptimal for concussion prevention in sport.
Effectiveness of a structured educational intervention using psychological delivery methods in children and adolescents with poorly controlled type 1 diabetes: a cluster-randomized controlled trial of the CASCADE intervention
Authors: Christie Deborah , Thompson Rebecca , Sawtell Mary , Allen Elizabeth , Cairns John , Smith Felicity , Jamieson Elizabeth , Hargreaves Katrina , Ingold Anne , Brooks Lucy , Wiggins Meg , Oliver Sandy , Jones Rebecca , Elbourne Diana , Santos Andreia , Wong Ian C K , O'Neil Simon , Strange Vicki , Hindmarsh Peter , Annan Francesca , Viner Russell M 
Published: June 2016

IntroductionType 1 diabetes (T1D) in children and adolescents is increasing worldwide with a particular increase in children <5 years. Fewer than 1 in 6 children and adolescents achieve recommended glycated hemoglobin (HbA1c) values.MethodsA pragmatic, cluster-randomized controlled trial assessed the efficacy of a clinic-based structured educational group incorporating psychological approaches to improve long-term glycemic control, quality of life and psychosocial functioning in children and adolescents with T1D. 28 pediatric diabetes services were randomized to deliver the intervention or standard care. 362 children (8–16 years) with HbA1c≥8.5% were recruited. Outcomes were HbA1c at 12 and 24 months, hypoglycemia, admissions, self-management skills, intervention compliance, emotional and behavioral adjustment, and quality of life. A process evaluation collected data from key stakeholder groups in order to evaluate the feasibility of delivering the intervention.Results298/362 patients (82.3%) provided HbA1c at 12 months and 284/362 (78.5%) at 24 months. The intervention did not improve HbA1c at 12 months (intervention effect 0.11, 95% CI −0.28 to 0.50, p=0.584), or 24 months (intervention effect 0.03, 95% CI −0.36 to 0.41, p=0.891). There were no significant changes in remaining outcomes. 96/180 (53%) families in the intervention arm attended at least 1 module. The number of modules attended did not affect outcome. Reasons for low uptake included difficulties organizing groups and work and school commitments. Those with highest HbA1cs were less likely to attend. Mean cost of the intervention was £683 per child.ConclusionsSignificant challenges in the delivery of a structured education intervention using psychological techniques to enhance engagement and behavior change delivered by diabetes nurses and dietitians in routine clinical practice were found. The intervention did not improve HbA1c in children and adolescents with poor control.Trial registration numberISRCTN52537669, results.
Nivolumab and Pembrolizumab for Non–Small Cell Lung Cancer
Authors: Morgensztern Daniel , Herbst Roy S. 
Published: June 2016

Abstract
The outcomes for patients with previously treated advanced stage non–small lung cancer (NSCLC) are very poor, with a modest benefit from chemotherapy over best supportive care. Immunotherapy offers a novel approach for the treatment of these patients, with two anti-programmed death 1 (PD-1) checkpoint inhibitors, nivolumab and pembrolizumab, recently approved by the FDA based on large randomized clinical trials showing increased overall survival compared with standard second-line docetaxel. Although only a subset of patients benefit from these drugs, the treatment is usually well tolerated and the responses are often durable, with an unprecedented number of survivors 3 years after starting the therapy. The next steps should be the identification of reliable predictors for benefit from immunotherapy with checkpoint inhibitors and the pursuit of well-designed combination therapies. In this article, we review the rationale for the use of checkpoint inhibitors in NSCLC, the data from phase I and randomized clinical trials, and future directions. Clin Cancer Res; 22(15); 3713–7. ©2016 AACR.
Prognostic relevance of circulating endothelial progenitor cells in patients with chronic heart failure
Authors: Koller Lorenz , Hohensinner Philipp , Sulzgruber Patrick , Blum Steffen , Maurer Gerald , Wojta Johann , Hülsmann Martin , Niessner Alexander 
Published: June 2016

SummaryNovel strategies for a tailored risk prediction in chronic heart failure (CHF) are crucial to identify patients at very high risk for an improved patient management and to specify treatment regimens. Endothelial progenitor cells (EPCs) are an important endogenous repair mechanism with the ability to counteract endothelial injury and the possibility of new vessel formation. We hypothesised that exhaustion of circulating EPCs may be a suitable prognostic biomarker in patients with CHF. EPCs, defined as CD34+CD45dimKDR+ cells, were analysed using fluorescence-activated cell sorting. EPCs were measured in 185 patients with CHF including 87 (47%) patients with ischaemic aetiology and 98 (53%) patients with non-ischaemic CHF and followed for a median time of 2.7 years. During this period, 34.7% of patients experienced the primary study endpoint all-cause mortality. EPC count was a significant and independent inverse predictor of mortality with an hazard ratio hazard ratio (HR) per increase of one standard deviation (1-SD) of 0.47 (95% confidence interval [CI]: 0.35–0.61; p<0.001) and remained significant after multivariable adjustment for a comprehensive set of cardiovascular risk factors and potential confounders with a HR per 1-SD of 0.54 (95% CI: 0.4–0.73; p<0.001). EPCs further demonstrated additional prognostic information indicated by improvements in C-statistic, net reclassification index and integrated discrimination increment. In conclusion, in our study circulating EPCs turned out as strong and independent inverse predictors of mortality underlining the importance of an impaired endothelial repair mechanism in the pathophysiology and progression of CHF.Supplementary Material to this article is available online at www.thrombosis-online.com.
On roman letters and other stories
Authors: Lock Charles 
Published: June 2016

This essay questions the assumption that the roman alphabet is more purely phonetic than any other, and that other scripts and writing-systems are less efficient, whether for the production of texts or for their comprehension. Those who habitually use roman letters are asked to consider their competence to understand other writing systems. The work of Stanley Morison emphasizes the ideological significance of alphabets and of particular letter-forms. M.B. Parkes and Paul B. Saenger are cited to indicate how punctuation and spacing are aspects of the roman-letter writing system that cannot be treated as purely phonetic. Beyond the world of roman letters there is a focus on Syriac and the Xi’an stele, which was printed by Athanasius Kircher in 1667 and marks the first publication in the west of a substantial text in Chinese.
Volatility Dynamics in Oil and Oilseeds Spot and Futures Market in India
Authors: Malhotra Meenakshi , Sharma Dinesh Kumar 
Published: June 2016

Executive Summary India occupies the fifth position in the vegetable oil economy of the world. The demand for oilseeds and vegetable oil has far exceeded the domestic output necessitating huge imports. Futures market helps to bring price stability for the development of the underlying physical market. The present study investigates the volatility dynamics in spot and futures markets of select oil and oilseeds commodities. The objectives of this article are to study (a) the information transmission process between spot and futures markets, also called volatility spillover and (b) the impact of futures trading activity on the volatility of physical market prices. The commodities selected from oil and oilseeds segment are refined soya oil, mustard seed, crude palm oil, and mentha oil. The study uses basic Generalized Autoregressive Conditional Heteroscedasticity (GARCH) model to capture volatility in prices of the selected commodities. Bivariate GARCH model makes use of information in the history of two different markets for testing volatility spillover between two markets of the same underlying commodity. The relationship between futures trading activity and spot price volatility is investigated for examining the impact of futures trading activity on the volatility of underlying spot market. Two variables, viz., futures trading volume and open interest are decomposed into expected and unexpected components and are taken as a proxy for the level of trading activity. The contemporaneous and dynamic relationships are studied with the help of augmented GARCH model and Granger causality, respectively. It is observed that there is an efficient transmission of information between spot and futures markets but it is the spot market which leads to the flow of information to futures and hence causes greater spillover of volatility. The spot market has a greater impact on the volatility of futures market, indicating that informational efficiency of oilseeds spot market is stronger than that of the futures market. The contemporaneous and dynamic relationship between spot price volatility and futures trading activity tested with econometric models provide evidence of the destabilizing impact of an unexpected increase in futures trading activity (volume or open interest) on the spot price volatility in three out of four commodities studied. This indicates that badly informed traders present in futures market are destabilizing the underlying spot market by inducing noise and lowering the information content of prices.