bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vitro Anti-inflammatory Effects of Larch Turpentine, Turpentine Oil, Eucalyptus Oil, and Their Mixture as Contained in a Marketed Ointment
Authors: Appel Kurt , Rose Thorsten , Zimmermann Christian , Günnewich Nils 
Published: September 2024

AbstractAn ointment containing larch turpentine, turpentine oil, and eucalyptus oil has been used for almost a century for the symptomatic treatment of mild, localized, purulent inflammations of the skin. Its clinical efficacy in the treatment of skin infections has been shown in clinical trials, but the mode of action of the active ingredients on inflammation is not known. We studied the anti-inflammatory properties of the active ingredients of the ointment and their mixture in a human monocyte cell model, in which the cells were stimulated with lipopolysaccharide and incubated with the test substances. The cytotoxic threshold of each test substance and the mixture was identified using the alamarBlue assay, and their anti-inflammatory activity was assessed by measuring the release of interleukins IL-1β, IL-6, IL-8, monocyte chemoattractant protein-1, prostaglandin E2, and TNF-α. Cell toxicity was observed at a mixture concentration of 10 µg/mL. All
immunological assays were carried out at nontoxic concentrations. Larch turpentine decreased IL-1β, monocyte chemoattractant protein-1, and prostaglandin E2 release at a concentration of 3.9 µg/mL and TNF-α at concentrations > 1.95 µg/mL, whereas eucalyptus oil and turpentine oil had no relevant inhibitory effects. The mixture dose-dependently inhibited IL-1β, IL-6, monocyte chemoattractant protein-1, prostaglandin E2, and TNF-α release at concentrations > 1 µg/mL. IL-8 release was only marginally affected. The anti-inflammatory activity of the herbal ingredients and their mixture was confirmed in this model. This effect seems to be mediated mainly by larch turpentine, with turpentine oil and eucalyptus oil exerting an additive or possibly synergistic function.
Hepatitis C Virus Infection in Pregnant Individuals with Opioid Use Disorder and Its Association with Preterm Birth
Authors: Cheedalla Aneesha , Berry Marissa , Abdelwahab Mahmoud , Cowen Jamie , Stiles Alexandra , Mason Isabelle , Honegger Jonathan R. , Rood Kara M. 
Published: September 2024

Objective Both hepatitis C virus (HCV) and opioid use disorder (OUD) have been associated with higher rates of preterm birth (PTB). It is unknown whether the higher prevalence of HCV in individuals with OUD may contribute to this association. The objective of this study is to evaluate the association between HCV and PTB in pregnant individuals with OUD.
Study Design We conducted a retrospective cohort of pregnant individuals with OUD who participated in more than three visits in a co-located multidisciplinary program. Inclusion criteria were a diagnosis of OUD, participation in treatment/prenatal care program, and laboratory evaluation of HCV status. The primary exposure was the presence of HCV antibodies, and secondarily, a detectable viral load (viremia). The primary outcome was PTB, which was further classified as spontaneous or iatrogenic. Multivariable logistic regression was used to detect associations while adjusting for race, history of prior PTB, and tobacco use.
Results A total of 941 individuals were included in the study, 404 with HCV and 537 without. Rates of PTB did not differ between those with compared to those without HCV (20.3 vs. 23.8%, adjusted odds ratio [aOR] = 0.75 [95% confidence interval (CI): 0.53–1.07]). There were similar rates of spontaneous PTB (13.1 vs. 16.2%, aOR = 0.79 [95% CI: 0.43–1.45]) and iatrogenic PTB (7.2 vs. 7.6%, aOR = 1.26 [95% CI: 0.69–2.30]). Comparing those with viremia to those without, there were also similar rates of overall PTB (21.6 vs. 17.9%, aOR = 0.86 [95% CI: 0.52–1.44]), spontaneous PTB (13.3 vs. 12.9%, aOR = 0.97 [95% CI: 0.52–1.87]), and iatrogenic PTB (8.3 vs. 5.0%, aOR = 1.83 [95% CI: 0.76–4.94]).
Conclusion HCV does not appear to be associated with spontaneous or iatrogenic PTB in pregnant persons with OUD who are engaged in treatment and prenatal care. The role of co-located multidisciplinary prenatal and addiction programs in the association between HCV and PTB warrants further investigation.
Key Points
Unfavorably Altered Fibrin Clot Phenotype in Women Following Postpartum Hemorrhage of Unknown Cause: Effect of Lower Coagulation Factors
Authors: Piróg Magdalena , Ząbczyk Michał , Natorska Joanna , Broniatowska Elżbieta , Jach Robert , Undas Anetta 
Published: September 2024

Background Increased clot permeability and susceptibility to lysis have been reported in women with heavy menstrual bleeding. We hypothesized that similar alterations in fibrin clot properties may also be present in women with postpartum hemorrhage (PPH) of unknown cause.
Objective To determine fibrin clot properties and their determinants in women after PPH of unknown cause.
Methods We studied 52 consecutive women, aged 35 years (27–40), after at least 3 months since PPH of unknown cause and 52 matched controls for age, weight, and fibrinogen. Coagulation factors (F), antithrombin, thrombin generation, along with a comprehensive plasma fibrin clot analysis including fibrin polymerization, clot permeability (K
s), and fibrinolysis efficiency were determined.
Results Women with PPH showed reduced activity of FII (−10.3%), FV (−6.6%), FIX (−6.5%), FX (−7.2%), and FXI (−5.7%) compared with the controls, though all values were within ranges (all p < 0.05). There were no intergroup differences in fibrinogen, FVIII, FXIII, and thrombin generation. The PPH group formed with a delay looser plasma fibrin network (K
s; +16.3%, p = 0.008) with lower maximum absorbance and shorter clot lysis time (CLT; −13.5%, p = 0.001) compared with the controls. On multivariable logistic regression, PPH was independently associated with higher C-reactive protein (per 1 mg/L, odds ratio [OR] = 1.70, 95% confidence interval [CI]: 1.09–2.68), lower FII (per 1%, OR = 0.93, 95% CI: 0.89–0.98), lower FV (per 1%, OR = 0.93, 95% CI: 0.89–0.97), and shorter CLT (per 1 minute, OR = 0.94, 95% CI: 0.90–0.98).
Conclusion Prohemorrhagic fibrin clot properties, with lower, though normal coagulation factors, characterize women with PPH of unknown cause, which suggests novel mechanisms contributing to this type of bleeding.
Assessing the Quality and Readability of Online Patient Information: ENT UK Patient Information e-Leaflets versus Responses by a Generative Artificial Intelligence
Authors: Shamil Eamon , Ko Tsz Ki , Fan Ka Siu , Schuster-Bruce James , Jaafar Mustafa , Khwaja Sadie , Eynon-Lewis Nicholas , D'Souza Alwyn , Andrews Peter 
Published: September 2024

Abstract
Background The evolution of artificial intelligence has introduced new ways to disseminate health information, including natural language processing models like ChatGPT. However, the quality and readability of such digitally generated information remains understudied. This study is the first to compare the quality and readability of digitally generated health information against leaflets produced by professionals.
Methodology Patient information leaflets from five ENT UK leaflets and their corresponding ChatGPT responses were extracted from the Internet. Assessors with various degrees of medical knowledge evaluated the content using the Ensuring Quality Information for Patients (EQIP) tool and readability tools including the Flesch-Kincaid Grade Level (FKGL). Statistical analysis was performed to identify differences between leaflets, assessors, and sources of information.
Results ENT UK leaflets were of moderate quality, scoring a median EQIP of 23. Statistically significant differences in overall EQIP score were identified between ENT UK leaflets, but ChatGPT responses were of uniform quality. Nonspecialist doctors rated the highest EQIP scores, while medical students scored the lowest. The mean readability of ENT UK leaflets was higher than ChatGPT responses. The information metrics of ENT UK leaflets were moderate and varied between topics. Equivalent ChatGPT information provided comparable content quality, but with reduced readability.
Conclusion ChatGPT patient information and professionally produced leaflets had comparable content, but large language model content required a higher reading age. With the increasing use of online health resources, this study highlights the need for a balanced approach that considers both the quality and readability of patient education materials.
Nasal Tip Reshaping in Orthognathic Surgery: A Novel Intraoral Minimally Invasive Approach
Authors: Santagata Mario , Boschetti Ciro Emiliano , Chagas-Junior Otacilio Luiz , Gualdi Alessandro , Rugge Luigi , Tartaro Gianpaolo , Chirico Fabrizio 
Published: September 2024

AbstractCurrent concepts in orthognathic surgery focus on not just rectifying dentoskeletal irregularities but also improving facial aesthetic and function. In this respect, nasal reshaping holds extraordinary significance in determining surgery effectiveness and patient satisfaction. Facial preoperative evaluations emphasize the paramount functional and aesthetic impacts of caudal septum in tip reshaping. Deviations in this anatomical subunit could lead to significant nasal obstructions and aesthetic changes as twisted nasal tip, affecting projection, rotation, and columellar–alar relationship. These considerations are essential in orthofacial surgery, as maxillary movements might exacerbate or worsen preexisting nasal tip deformity. In this paper, we aim to describe a novel and innovative minimally invasive approach presenting a detailed account of a rhinoseptoplasty in which the entire nasal tip reshaping procedure was performed intraorally during orthognathic surgery. The technique focused on achieving optimal nasal tip projection and rotation, centering, and stabilization through strategic maneuvers such as incremental dissection of maxillary spine chondroperiosteal junction, superoposterior strut preservation, vertical and caudal septum resection, and anterior nasal spine tip support. Techniques including subnasal drilling and septal stabilization suture are detailed. Specific attention is given to addressing deficiencies in posterior septal angle and labiocolumellar relationship. Postoperative care is described and subjective evaluations were performed to assess patient and surgeon satisfaction with facial symmetry and overall aesthetic improvements. In our experience, the described approach offers valuable surgical finesse to orthognathic surgery, effectively targeting caudal septum deviations and nasal tip droopy. Its unique perspective enhances both functional and aesthetic results, particularly in the context of profiloplasty. No external nasal incision was performed and the totality of nasal tip reshaping was scarless and performed through an intraoral approach. Surgical precision in execution of this novel and tailored surgical approach has been shown to have a profound impact for enhancing outcomes of orthofacial surgery procedure.
Patellar Tendon Ruptures after Total Knee Arthroplasty
Authors: Swartz Gabrielle , Bonanni Sean , Hameed Daniel , Dubin Jeremy A. , Bains Sandeep S. , Patel Deepak V. , Mont Michael A. , Delanois Ronald E. , Scuderi Giles R. 
Published: September 2024

AbstractPatellar tendon (PT) rupture following total knee arthroplasty (TKA) is a rare, but devastating complication. These injuries occur most frequently in the acute period following TKA due to trauma to the knee. PT ruptures that disrupt the extensor mechanism create a marked functional deficit, impacting every facet of daily life. In complete ruptures of the PT, repair or reconstruction is typically indicated; however, complication rates following intervention remain high. Operative intervention remains the mainstay of treatment, with only certain specific situations where nonoperative intervention is appropriate. Operative techniques are chosen based on the acuity, location of disruption, and status of the residual soft tissues. Treatment options include repair with or without augmentation or reconstruction. Augmentation does reduce the high risk of complications, bringing rates down from 63 to 25%. Augmentation options include autografts, allografts, synthetic grafts, or synthetic meshes. Despite advancements, outcomes are unpredictable and complications are common, highlighting the need for further research to improve treatment protocols. This article provides an overview of PT ruptures following TKA, the various treatment options, and the recommendations of the M.M., R.D., G.S. for each common type of PT injury encountered.
Elevated Thrombin Generation and Venous Thromboembolism Incidence in Patients Undergoing Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy Compared with Minimally Invasive Rectal Surgery
Authors: Lundbech Mikkel , Krag Andreas E. , Iversen Lene H. , Brandsborg Birgitte , Madsen Nina , Hvas Anne-Mette 
Published: September 2024

Introduction Surgical treatment of colorectal cancer carries a risk for venous thromboembolism (VTE). We investigated changes in coagulation and fibrinolysis and the VTE incidence within 30 days in patients undergoing open cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) for peritoneal metastases from colorectal cancer and minimally invasive surgery (MIS) for localized rectal cancer.
Methods This cohort study included 45 CRS + HIPEC and 45 MIS patients. Blood samples were obtained preoperatively, at the end of surgery, and postoperative day (POD) 1, 3 to 4, and 5 to 7. Systematic ultrasonographic screening for VTE was performed between POD 3 and 7. Computed tomography scan was performed if complications were suspected. The primary endpoint was the difference in mean change (Δ) with [95% confidence intervals] from preoperative to end of surgery in prothrombin fragment 1 + 2 (F1 + 2) levels. Secondary endpoints were the difference in mean change in biomarkers of coagulation and fibrinolysis from preoperative to POD 5 to 7 and the VTE incidence.
Results F1 + 2 levels increased from preoperative to the end of surgery in both groups. The mean increase from preoperative to end of surgery in F1 + 2 levels was significantly greater in CRS + HIPEC patients than MIS patients: Δ1,322 [1,040:1,604] pmol/L, p < 0.01. The VTE incidence was significantly higher after CRS + HIPEC than MIS (24 vs. 5%, p = 0.01).
Conclusion F1 + 2 levels were increased after both procedures, but to a far greater extent following CRS + HIPEC. The VTE incidence within 30 days was significantly higher in patients treated with CRS + HIPEC than in MIS patients.
Photoinduced Stereoselective Giese Addition on Coumarins
Authors: Singh Ravi P. , Singh Shashank 
Published: September 2024

AbstractDiastereoselective Giese addition on coumarin-3-carboxylate bearing a chiral auxiliary with N-hydroxyphthalimide ester to generate the corresponding alkylated adduct has been explored. Among screened chiral auxiliaries, bulkier one with appropriate steric hindrance is better for diastereoselective addition. Mechanistic studies involving fluorescence studies and On/Off experiments shed insight onto the plausible reaction pathway.
Focuses and Trends of Research on Platelet-Rich Fibrin: A Bibliometric and Visual Analysis
Authors: Zhao Ying , Dong Chen , Fan Liumeizi , Lei Ting , Ge Xin , Yu Zhou , Hu Sheng 
Published: September 2024

Abstract
Background A rapid expansion of study on platelet-rich fibrin (PRF) has gained more attention in the subject. In this study, bibliometrics were used to assess the outputs and trends of relevant PRF studies. An in-depth analysis of the publication patterns and progress in PRF research worldwide was conducted for the purpose of filling in this research gap.
Materials and Methods The analysis included 946 papers sourced from Web of Science that included 842 original articles and 104 reviews. A number of factors including country/region, institution, journal, and author were taken into account. Research on PRF development trends was mapped using the frequency of keywords.
Results In terms of the total number of publications, China ranked first with 199 papers, whereas the United States ranked first on the H-index with 37. PRF is an active research area in stomatology and craniomaxillofacial surgery. Keywords provided by the authors were designated to three clusters: red, green, and blue. “Growth factor,” “platelet-rich plasma,” and “bone regeneration” were the most frequent keywords in each cluster, which reflect the current interests in corresponding fields. Bone regeneration post-dental extractions is one of the main application directions in the field of oral and maxillofacial surgery. “Membrane,” “injectable PRF (I-PRF),” “case report,” and “advanced PRF (A-PRF)” were relative recent keywords in all clusters, indicating that manufacturing processes and new applications are promising research hotspots in the field.
Conclusion In the future, the applications of modified PRF, such as I-PRF, are promising research hotspots. Moreover, strict randomized controlled trials on PRF deserve more attention. The results of this analysis may be helpful for all scholars seeking to expand researches and innovations in the field of PRF.
Perioperative Complications of Oblique Lumbar Interbody Fusion (OLIF): 5 Years of Experience with OLIF
Authors: Johnson Alex T. , Kumar Ganesh , Mohapatra Bibhudendu , Mahajan Rajat 
Published: September 2024

Abstract
Objective The objective of this study was to share our early experience with oblique lumbar interbody fusion (OLIF), with emphasis on the perioperative complications and determine clinical outcomes following OLIF.
Materials and Methods It was a retrospective prospective study performed at a single institute from March 2019 to August 2023. A total of 56 consecutive patients who had undergone OLIF for degenerative spine disorders were enrolled in the study. Pre-, intra-, and postoperative data on these patients were collected. All the patients were followed up at regular intervals with an evaluation of Visual Analog Scale (VAS), Oswestry Disability Index (ODI), neurological parameters, and X-rays to look for fusion, screw loosening, pseudoarthrosis, and cage slippage. Statistical analysis was done with the odds ratio, chi-square test, and Student's t-test. A p-value of < 0.05 was considered significant.
Results The overall incidence of complications was 25%, with no mortality. Intraoperative complications were noted in 10.7% of cases. This included endplate fractures (n = 3), peritoneal lacerations (n = 2), and ureteric injury (n = 1). The most common early postoperative complications were postoperative ileus (n = 6), followed by anterior thigh or groin numbness (n = 3), ipsilateral psoas weakness (n = 2), and superficial surgical site infection (n = 2). Of the late postoperative complications, cage subsidence was the most common, which occurred in 4 patients, followed by adjacent segment degeneration (n = 2) and loss of indirect decompression (n = 1). The mean ODI and VAS scores showed significant improvement (p < 0.05) at the final follow-up.
Conclusion OLIF is a promising surgical technique with the potential to treat a variety of degenerative conditions of the lumbar spine with a good clinical outcome. Despite its various benefits, OLIF can lead to complications in rare instances, which every spine surgeon should be aware of.
A real options approach to data valuation
Authors: Coyle Diane , Gamberi Luca 
Published: September 2024

AbstractValuing data assets presents a significant challenge in the modern business environment, even though it is widely accepted that data have significant value for commercial outcomes. Data are an intangible asset with non-rival characteristics and moreover its future uses may be highly uncertain as the market environment and technology change. In this paper, we propose one practical and flexible solution for valuing business data using well-established real option pricing theory. We discuss how to best select the appropriate proxy for each variable involved. As an illustration of our method, we present a calculation (using only publicly available data) of the initial option value of setting up a supermarket loyalty card scheme for customer data. The value resulting from the calculation is reasonably close to the recently reported realized sales figure for the supermarket data. The easy-to-use tool we propose can serve practitioners as a starting point for strategic decision-making regarding investing in their data assets, even in situations where their use cases are not fully known, and future project outcomes are uncertain.
Low-energy N+ ion beam induced chemical vapor deposition using tetraethyl orthosilicate, hexamethyldisiloxane, or hexamethyldigermane
Authors: Yoshimura Satoru , Takeuchi Takae , Kiuchi Masato 
Published: September 2024

In this study, we conducted an experiment in which a source material was sprayed onto a substrate with simultaneous N+ ion beam injections. Hexamethyldisiloxane (HMDSO) or tetraethyl orthosilicate (TEOS) was used as a source material. The energy of N+ ions was set at 100 eV. The substrate temperature was set at room temperature. As a result of each trial, a film was deposited on the substrate in both HMDSO and TEOS cases. The film was analyzed by x-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) spectroscopy. We found that the film was silicon dioxide and nitrogen atoms (2–4 at. %) were included in the film. For comparison, a trial was also conducted in which hexamethyldigermane (HMDG) was sprayed onto a substrate with simultaneous 30 eV N+ ion beam injections. Although HMDG had no oxygen atoms in its molecule, XPS and FTIR results showed that the film was germanium oxide containing nitrogen (2 at. %).
Sharp boundary concentration for a two-dimensional nonlinear Neumann problem*
Authors: De Marchis Francesca , Fourti Habib , Ianni Isabella 
Published: September 2024

Abstract
We consider the elliptic equation

−
Δ
u
+
u
=
0

in a bounded, smooth domain

Ω
⊂

R

2

subject to the nonlinear Neumann boundary condition

∂
u

/

∂
ν
=

|

u

|

p
−
1

u

on

∂
Ω

and study the asymptotic behaviour as the exponent

p
→
+
∞

of families of positive solutions up
satisfying uniform energy bounds. We prove energy quantisation and characterise the boundary concentration. In particular we describe the local asymptotic profile of the solutions around each concentration point and get sharp convergence results for the

L

∞

-norm.
Gravitational music: a mathematical-musical model for the popularization of gravitational waves
Authors: Bile Alessandro , Santoboni Riccardo , Frasca Sergio , Astone Pia 
Published: September 2024

Abstract
Nowadays scientific research, supported by technological development, proceeds at an inexorable speed. Thus, technical features could be difficult to understand for many of the population. Therefore, the research for a universal language has now become fundamental. At the same time, in the post-digital era, artistic research approached technology. The link between art and science has very ancient roots but in recent years has reached a complete overlap. For example, this is the case of the sonification process, which consists of the use of un-speech audio to transmit information. In this paper, we present Gravitational Music, an installation able to translate the physical phenomenon of gravitational waves propagation into sound, by exploiting an artistic approach. Gravitational Music is an efficient teaching tool that can be used for both school and adult purposes to simplify the complex language of science.