bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microchannel plate fabrication using glass capillary arrays with Atomic Layer Deposition films for resistance and gain
Authors: Popecki M. A. , Adams B. , Craven C. A. , Cremer T. , Foley M. R. , Lyashenko A. , O'Mahony A. , Minot M. J. , Aviles M. , Bond J. L. , Stochaj M. E. , Worstell W. , Elam J. W. , Mane A. U. , Siegmund O. H. W. , Ertley C. , Kistler L. M. , Granoff M. S. 
Published: July 2016

AbstractMicrochannel plates (MCPs) have been used for many years in space flight instrumentation as fast, lightweight electron multipliers. A new MCP fabrication method combines a glass substrate composed of hollow glass capillary arrays with thin film coatings to provide the resistive and secondary electron emissive properties. Using this technique, the gain, resistance, and glass properties may be chosen independently. Large‐area MCPs are available at moderate cost. Secondary emission films of Al2O3 and MgO provide sustained high gain as charge is extracted from the MCP. Long lifetimes are possible, and a total extracted charge of 7 C/cm2 has been demonstrated. Background rates are low because the glass substrate has little radioactive potassium 40. Curved MCPs are easily fabricated with this technique to suit instrument symmetries, simplifying secondary electron steering and smoothing azimuthal efficiency.
Mitigation of narrowband interferences by means of a reconfigurable stepped frequency GPR system
Authors: Persico Raffaele , Dei Devis , Parrini Filippo , Matera Loredana 
Published: July 2016

AbstractThis paper proposes a new technique for the mitigation of narrowband interferences by making use of an innovative stepped frequency Ground Penetrating Radar (GPR) system, based on the modulation of the integration time of the harmonic components of the signal. This can allow a good rejection of the interference signal without filtering out part of the band of the useful signal (which would involve a loss of information) and without increasing the power of the transmitted signal (which might saturate the receiver and make illegal the level of transmitted power). The price paid for this is an extension of the time needed in order to perform the measurements. We will show that this necessary drawback can be contained by making use of a prototypal reconfigurable stepped frequency GPR system.
Rapport‐Building in Investigative Interviews of Alleged Child Sexual Abuse Victims
Authors: Price Eleanor A. , Ahern Elizabeth C. , Lamb Michael E. 
Published: July 2016

SummaryResearch shows that both utterance type and rapport‐building can affect children's productivity during the substantive phase of investigative interviews. However, few researchers have examined the effects of utterance type and content on children's productivity within the rapport‐building phase. In the present study, transcripts of interviews with 94 4‐ to 13‐year‐old alleged victims were examined. Interviews were conducted using either the National Institute of Child Health and Human Development (NICHD) Protocol or the Memorandum of Good Practice (MoGP). The NICHD Protocol interviews contained more invitations and questions about events and hobbies/likes than the MoGP interviews. Children's productivity was associated with utterance type and topic, showing both the benefits of invitations and questions asking about past events. Our findings complement research focusing on the substantive phase of child forensic interviews, suggesting that both utterance type and prompt content during the rapport‐building phase can affect children's immediate productivity. Copyright © 2016 John Wiley & Sons, Ltd.
Methods for Influencing Social Policy: The Role of Social Experiments
Authors: Shinn Marybeth 
Published: July 2016

AbstractResearch methods in community psychology have grown more diverse since the Swampscott conference, but rigorous social experiments maintain a place among the multiplicity of methods that can promote community psychology values. They are particularly influential in policy circles. Two examples of social experiments to end homelessness for different populations illustrate their role. Both studies show that offering extremely poor and disenfranchised people autonomy and the resources they seek works better than “helping” them to overcome deficits in ways designed by well‐meaning service providers. Experiments are neither the first nor the last method community psychologists should employ, but are a critical part of the field's armamentarium for systems change.
Copper‐Catalyzed Enantioselective Allyl–Allyl Coupling between Allylic Boronates and Phosphates with a Phenol/N‐Heterocyclic Carbene Chiral Ligand
Authors: Yasuda Yuto , Ohmiya Hirohisa , Sawamura Masaya 
Published: July 2016

AbstractCopper‐catalyzed enantioselective allyl–allyl coupling between allylboronates and either Z‐acyclic or cyclic allylic phosphates using a new chiral N‐heterocyclic carbene ligand, bearing a phenolic hydroxy, is reported. This reaction occurs with exceptional SN2′‐type regioselectivities and high enantioselectivities to deliver chiral 1,5‐diene derivatives with a tertiary stereogenic center at the allylic/homoallylic position.
Ageing properties of polyurethane methacrylate and off‐stoichiometry thiol‐ene polymers after nitrogen and argon plasma treatment
Authors: Chen Tiam Foo , Siow Kim Shyong , Ng Pei Yuen , Nai Mui Hoon , Lim Chwee Teck , Yeop Majlis Burhanuddin 
Published: July 2016

ABSTRACTProprietary mixture of polyurethane methacrylate (PUMA) and off‐stoichiometry thiol‐ene (OSTE‐80) are evaluated as two possible polymeric substrates to prototype microfluidic biochips. Because of their lack of biocompatibility, PUMA and OSTE‐80 are modified by argon (Ar) or nitrogen (N2) plasma treatment to introduce nitrogen moieties that are highly polar and conducive for cell attachment and growth. XPS and water contact angle measurement show that these nitrogen groups are relatively stable in the plasma‐treated PUMA and OSTE‐80 in spite of the hydrophobic recovery and volatilization of nitrogen moieties during air ageing for 15 days. This stability can be attributed to their high degree crosslinking that is reflected by the increase of elastic modulus of PUMA and OSTE‐80 during their air ageing. These results show that Ar and N2 plasma‐treated PUMA and OSTE‐80 possess the necessary physical and chemical properties to be evaluated further to develop microfluidic biochips for biological applications. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44107.
Light scattering materials with tunable optical properties by controlling refractive index of the dispersed phase
Authors: Liu Xiao , Dong Xianming , Xiong Ying , Yi Ping , Ren Yikun , Guo Shaoyun 
Published: July 2016

ABSTRACTTraditionally, the morphologies of the dispersed phase in Polycarbonate (PC)/poly(styrene‐co‐acrylonitrile) (SAN) blends were strongly influenced if AN content in SAN changed significantly even under constant processing conditions. This would hinder the pure research intended to study the effect of the refractive index difference between the polymer host and the polymeric dispersed particles on the optical properties tough. Therefore, we respectively prepared different PC/SAN light diffusion sheets with four types of SAN containing different AN content ranging just from 20 to 25 wt %, a narrow range that sufficiently ensures the relatively stable morphology of different SAN in PC matrix. The results suggest that the refractive index of SAN increases with an decreasing AN content, thus narrowing the refractive index difference between PC and SAN and producing PC/SAN(70/30) light diffusion sheets with an increasing transmittance and decreasing haze. The interesting phenomenon is further analyzed using Mie scattering theory. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44156.
Retarding hydrolytic degradation of polylactic acid: Effect of induced crystallinity and graphene addition
Authors: Finniss Adam , Agarwal Sushant , Gupta Rakesh 
Published: July 2016

ABSTRACTThe combination of elevated temperature and humidity leads to rapid degradation of polylactic acid (PLA) because of hydrolysis. Consequently, PLA, which is a bio‐derived and biodegradable polymer, is not currently used for durable applications since properties cannot always be maintained over time. In this work, the ability of polymer crystals to reduce the rate of degradation during accelerated aging tests was studied. Also examined was the influence of addition of 2 wt % graphene nanoplatelets to act as moisture transport barriers in the polymer. PLA samples were immersed in aqueous media of different pH or exposed to 100% relative humidity at 50 °C for different lengths of time to study the hydrolytic degradation behavior. In addition to monitoring the loss in mass of the samples, the values of crystallinity, melt viscosity, and mechanical properties, among others, were measured as functions of aging time using techniques such as DSC and rheometry. It was found that both crystallization and graphene addition are able to slow down the rate of degradation at short times, but significant degradation of PLA still occurs at long times. This is because PLA crystallites and graphene nanoplatelets can only reduce, but not eliminate, moisture diffusion into the polymer sample. Between the use of nanoplatelets and crystals, though, the former approach may be the better choice since enhanced crystallization tends to make PLA brittle. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44166.
Determination of epacadostat, a novel IDO1 inhibitor in mouse plasma by LC–MS/MS and its application to a pharmacokinetic study in mice
Authors: Dhiman Vinay , Giri Kalpesh Kumar , S Suresh P. , Zainuddin Mohd , Rajagopal Sriram , Mullangi Ramesh 
Published: July 2016

AbstractA sensitive, specific and rapid LC‐ESI‐MS/MS method has been developed and validated for the quantification of epacadostat in mouse plasma using tolbutamide as an internal standard (IS) as per regulatory guidelines. Sample preparation was accomplished through a protein precipitation. Chromatographic separation was performed on an Atlantis dC18 column using a binary gradient using mobile phase A (acetonitrile) and B (0.2% formic acid in water) at a flow rate of 0.90 mL/min. Elution of epacadostat and IS occurred at ~2.41 and 2.51 min, respectively. The total chromatographic run time was 3.2 min. A linear response function was established in the concentration range of 1.07–533 ng/mL. The intra‐ and inter‐day accuracy and precision were in the ranges of 1.81–12.9 and 3.80–11.1%, respectively. This novel method has been applied to a pharmacokinetic study in mice.
Trends in phase III randomized controlled clinical trials on the treatment of advanced non‐small‐cell lung cancer
Authors: Fernández‐López Cristina , Expósito‐Hernández José , Arrebola‐Moreno Juan Pedro , Calleja‐Hernández Miguel Ángel , Expósito‐Ruíz Manuela , Guerrero‐Tejada Rosa , Linares Isabel , Cabeza‐Barrera José 
Published: July 2016

AbstractThe objective of this review was to analyze trends in outcomes and in the quality of phase III randomized controlled trials on advanced NSCLC published between 2000 and 2012, selecting 76 trials from a total of 122 retrieved in a structured search. Over the study period, the number of randomized patients per trial increased by 14 per year (P = 0.178). The sample size significantly increased between 2000 and 2012 in trials of targeted agents (460.1 vs. 740.8 patients, P = 0.009), trials of >1 drug (360.4 vs. 584.8, P = 0.014), and those including patients with good performance status (675.3 vs. 425.6; P = 0.003). Quality of life was assessed in 46 trials (60.5%), and significant improvements were reported in 10 of these (21.7%). Platinum‐based regimens were the most frequently investigated (86.8% of trials). Molecular‐targeted agents were studied in 25.0% of chemotherapy arms, and the percentage of trials including these agents increased each year. The median (interquartile range) overall survival (MOS) was 9.90 (3.5) months with an increase of 0.384 months per year of publication (P < 0.001). A statistically significant improvement in MOS was obtained in only 13 (18.8%) trials. The median progression‐free survival was 4.9 (1.9) months, with a nonsignificant increase of 0.026 months per year (P > 0.05). There has been a continuous but modest improvement in the survival of patients with advanced NSCLC over the past 12 years. Nevertheless, the quality of clinical trials and the benefit in outcomes should be carefully considered before the incorporation of novel approaches into clinical practice.
Chemical Polymorphism of Origanum compactum Grown in All Natural Habitats in Morocco
Authors: Aboukhalid Kaoutar , Lamiri Abdeslam , Agacka‐Mołdoch Monika , Doroszewska Teresa , Douaik Ahmed , Bakha Mohamed , Casanova Joseph , Tomi Félix , Machon Nathalie , Faiz Chaouki Al 
Published: July 2016

Origanum compactum L. (Lamiaceae) is one of the most important medicinal species in term of ethnobotany in Morocco. It is considered as a very threatened species as it is heavily exploited. Its domestication remains the most efficient way to safeguard it for future generations. For this purpose, wide evaluation of the existing variability in all over the Moroccan territory is required. The essential oils of 527 individual plants belonging to 88 populations collected from the whole distribution area of the species in Morocco were analyzed by GC/MS. The dominant constituents were carvacrol (0 – 96.3%), thymol (0 – 80.7%), p‐cymene (0.2 – 58.6%), γ‐terpinene (0 – 35.2%), carvacryl methyl ether (0 – 36.2%), and α‐terpineol (0 – 25.8%). While in the Middle Atlas region and the Central Morocco mainly carvacrol type samples were found, much higher chemotypic diversity was encountered within samples from the north part of Morocco (occidental and central Rif regions). The high chemical polymorphism of plants offers a wide range for selection of valuable chemotypes, as a part of breeding and domestication programs of this threatened species.
Variation of Chemical Composition in Flowers and Leaves Essential Oils Among Natural Population of Tunisian Glebionis coronaria (L.) Tzvelev (Asteraceae)
Authors: Haouas Dalila , Cioni Pier Luigi , Flamini Guido , Ben Halima‐Kamel Monia , Ben Hamouda Mohamed Habib 
Published: July 2016

The aim of this study was to assess the percentage and constituents variations in flowers and leaves essential oil of three Glebionis coronaria (L.) Tzvelev population, growing wildly in three different ecotypes (Utique, M'saken, and Sahara Lektar) in Tunisia. The chemical compositions of these essential oils were analyzed by the GC and GC/MS systems. Qualitative and quantitative differences were recorded between essential oils extracted from plants collected from the three geographical provinces and between organs of the same plant (leaves and flowers). In fact, 161 components representing 87.2 – 96.5% of the whole oils were identified. Myrcene (3.2 – 35.7%), (Z)‐β‐ocimene (0.6 – 23.0%), camphor (0.6 – 17.2%), cis‐chrysanthenol (0 – 6.9%), cis‐chrysanthenyl acetate (1.1 – 17.9%), isobornyl acetate (1.6 – 3.5%), (E)‐β‐farnesene (0 – 6.0%), germacrene D (0 – 8.7%), and (E,E)‐α‐farnesene (0.7 – 12.4%) were the predominant components in the oils. These major constituents occur in different amounts depending on the organs (leaves or flowers) and the geographical origin of the plant. The chemotaxonomic usefulness of these data was discussed according to results of principal component analysis (PCA). The scores, together with the loadings, revealed a different chemical pattern for each population.
Chemical Composition and in vitro Biological Activities of Essential Oils from Conchocarpus fontanesianus (A. St.‐Hil.) Kallunki & Pirani (Rutaceae)
Authors: Cabral Rodrigo S. , Suffredini Ivana B. , Young Maria C. M. 
Published: July 2016

This study aimed at assessing the chemical composition of the essential oils from leaves and fruits of Conchocarpus fontanesianus, an endemic Brazilian species of Rutaceae. The plant material was harvested from two regions of the Atlantic rainforest in the State of São Paulo. The volatile compounds in the essential oils were extracted by hydrodistillation (HD), and analyzed by GC/FID and GC/MS, allowing the quantification and identification of 54 components in total, which comprise about 97% of the total oil composition. From the leaves collected in Caraguatatuba and Juréia‐Itatins, the major volatile compounds identified were as follows: spathulenol (22.32% and 16.67%) and α‐cadinol (9.7% and 14.76%). However, β‐myrcene (34.56%), (+)‐epi‐bicyclosesquiphellandrene (8.71%), and bicyclogermacrene (5.80%) were dominant in the fruits collected only in Juréia‐Itatins. The in vitro biological activities were tested to evaluate the cytotoxic, antifungal, and antioxidant potential of essential oils from leaves and fruits.
Phytochemical Compounds from the Crop Byproducts of Tunisian Globe Artichoke Cultivars
Authors: Dabbou Sihem , Dabbou Samia , Flamini Guido , Pandino Gaetano , Gasco Laura , Helal Ahmed Noureddine 
Published: July 2016

The phytochemical composition in two Tunisian globe artichoke cultivars (bracts, leaves, and floral stems) was evaluated in the plant byproducts. The results indicated that the bracts contain the highest levels of total phenols, o‐diphenols, and flavonoids, whereas tannins seem to be more abundant in the leaves. Bracts from the ‘Violet d'Hyères’ cultivar possessed more total phenols (160.8 mg/g DW), flavonoids (64.9 mg/g DW), and anthocyanins (15.3 μg/g DW) than the ‘Blanc d'Oran’ bracts (134.5 mg/g DW, 51.2 mg/g DW, and 8.3 μg/g DW, resp.). Sixty‐four volatile compounds were identified in the headspace of globe artichoke material, particularly in the bracts. The volatile profile showed that sesquiterpene hydrocarbons and non‐terpene derivatives were the main volatiles emitted by the bracts in both cultivars. These results suggest that globe artichoke byproducts might represent a potential source of natural compounds, which could be used as nutraceuticals or as ingredients in the design of functional foods.
Synthesis and Biological Evaluation of Matijin‐Su Derivatives as Potential Antihepatitis B Virus and Anticancer Agents
Authors: Qiu Jingying , Xu Bixue , Gong Qineng , Pan Weidong , Liu Changxiao , Huang Zhengming , Gu Xiaoke , Liang Guangyi 
Published: July 2016

A series of Matijin‐Su (MTS, (2S)‐2‐{[(2S)‐2‐benzamido‐3‐phenylpropanoyl]amino}‐3‐phenylpropyl acetate) derivatives were synthesized and evaluated for their anti‐HBV and cytotoxic activities in vitro. Six compounds (4g, 4j, 5c, 5g, 5h and 5i) showed significant inhibition against HBV DNA replication with the IC50 values in range of 2.18 – 8.55 μm, which were much lower than that of positive control lamivudine (IC50 82.42 μm). In particular, compounds 5h (IC50 2.18 μm; SI 151.59) and 5j (IC50 5.65 μm; SI 51.16) displayed relatively low cytotoxicities, resulting in high SI values. Notably, besides the anti‐HBV DNA replication activity, compound 4j also exhibited more potent in vitro cytotoxic activity than 5‐fluorouracil in two hepatocellular carcinoma cell (HCC) lines (QGY‐7701 and SMMC‐7721), indicating that 4j may be a promising lead for the exploration of drugs with dual therapeutic effects on HBV infection and HBV‐induced HCC.
Four New Kaurane Diterpenoids from the Chinese Liverwort Jungermannia comata Nees
Authors: Li Rui‐Juan , Wang Song , Li Gang , Zhou Jin‐Chuan , Zhang Jiao‐Zhen , Zhang You‐Ming , Shi Guo‐Sheng , Lou Hong‐Xiang 
Published: July 2016

In our continuing program to find new bioactive compounds from the Chinese liverworts, four new kaurane‐type diterpenoids, (6β)‐kaur‐16‐ene‐6,9‐diol (1), (6β,12β)‐kaur‐16‐ene‐6,9,12‐triol (2), (6β)‐kaur‐16‐ene‐5,6,9‐triol (3), and kaur‐16‐ene‐9,19‐diol (4), have been isolated from the Chinese liverwort Jungermannia comata Nees. Five known kaurane‐type diterpenoids (5 – 9) and four known trachylobane‐type diterpenoids (10 – 13) were also obtained. The structures of the new compounds were established unequivocally on the basis of spectroscopic data. The absolute configuration of compound 1 was established by comparing experimental and calculated electronic circular dichroism spectra.
Chemical Composition and Antimicrobial Activity of the Essential Oil from Aerial Parts and Roots of Eryngium barrelieri Boiss. and Eryngium glomeratum Lam. from Tunisia
Authors: Landoulsi Ameni , Roumy Vincent , Duhal Nathalie , Skhiri Fethia Harzallah , Rivière Céline , Sahpaz Sevser , Neut Christel , Benhamida Jeannette , Hennebelle Thierry 
Published: July 2016

The study of chemical composition and biological activity of unexplored essential oils may open new perspectives on their potential use in facing major health concerns such as drug‐resistant infections. The present study investigates the chemical composition and antimicrobial effects of previously unstudied essential oils obtained from genus Eryngium: Eryngium glomeratum Lam. and Eryngium barrelieri Boiss. The chemical compositions of the essential oils from aerial parts and roots of both species were studied using GC and GC/MS analytical technics. The analysis led to the identification of 102 compounds totalizing 85 – 94% of all detected compounds. Essential oils were characterized by the predominance of oxygenated sesquiterpenes. The oils obtained from aerial parts were tested against 36 microbial strains by agar dilution method and showed minimum inhibitory concentrations (MIC) in the range of 2 – 625 μg/ml. A strong antibacterial activity against multiresistant Pseudomonas aeruginosa was observed especially from E. glomeratum essential oil with MIC value up to 2 μg/ml. These findings give significant information about the pharmacological activity of these essential oils, which suggest their potential use to develop new remedies, or as sources of active compounds.
Fusaproliferin, Terpestacin and Their Derivatives Display Variable Allelopathic Activity Against Some Ascomycetous Fungi
Authors: Cimmino Alessio , Sarrocco Sabrina , Masi Marco , Diquattro Stefania , Evidente Marco , Vannacci Giovanni , Evidente Antonio 
Published: July 2016

Herbivorous mammal dung supports a large variety of fimicolous fungi able to produce different bioactive secondary metabolites to compete with other organisms. Recently, the organic extracts of the Solid State Fermentation (SSF) cultures of Cleistothelebolus nipigonensis and Neogymnomyces virgineus, showing strong antifungal activity, were preliminarily investigated. This manuscript reports the isolation of the main metabolites identified, using spectroscopic and optical methods, as fusaproliferin (1) and terpestacin (2). Furthermore, some key hemisynthetic derivatives were prepared and their antifungal activity was tested against the same fungi previously reported to be affected by the organic extracts obtained from SSF. These metabolites and their derivatives resulted able to reduce the growth of Alternaria brassicicola, Botrytis cinerea and Fusarium graminearum in a variable extent strongly dependent from chemical modifications and test fungi. The hydroxy enolic group at C(17) appeared to be a structural feature important to impart activity. This study represents the first report of these secondary metabolites produced by C. nipigonensis and N. virgineus.