bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jugaad Culture Amidst COVID-19: A Time to Step Up for Innovation in Low-Income Countries.
Authors: Baral Suman 
Published: September 2024

More than four months have already elapsed after the world first encountered Coronavirus claimed to originate from Wuhan, China. Scientifically, termed sudden acute respiratory syndrome corona virus (SARS-CoV-2), that causes Coronavirus disease of 2019 (COVID-19), this deadly pathogen has already claimed about 2.83 lakhs casualties with four million infected and 1.5 million recovered as of 11 May 2020. Different preventive measures like hand washing, social distancing, nation-wide lock down from March 23 have been practised inNepal which has definitely dwindled the number of positive cases. they have helped flatten the curve and procure time for preparation for forthcoming disaster. Total documented positive cases have been 120 till date (11 May 2020) with zero mortality in Nepal. However, the scenario might be out of control in coming days where claims of inadequate testing due to lack of diagnostic kits have been a major issue. Whatever be the outcome in upcoming days, for an economically poor country like Nepal, preparation seems satisfactory despite challenges to outsourcing the necessary kits like Personal Protective Equipment (PPE) and diagnostic Polymerase Chain Reaction (PCR) machines etc.
Coping with COVID-19
Authors: Nepal Bhagavat 
Published: September 2024

Severe acute respiratory syndrome corona virus (SARS-CoV-2) virus made its first appearance in Wuhan, China in December 2019. It has since spread like a wild fire across the globe with over five million corona virus disease (COVID-19) confirmed cases and almost three hundred fifty thousand deaths at the time of writing this article. This could however be only the tip of the iceberg considering the contagious nature of the SARS-CoV-2 virus and the rate at which it is spreading across the globe. China did well to contain the virus with strict lockdown measures, sealing the affected areas, active case finding, tracing, tracking and treating the COVID-19 cases at an astonishing speed. In the absence of specific treatment available as yet, treatment consists of mainly symptomatic management with some experimental medications. Antivirals, specifically Remdesivir has been a strong candidate for the treatment of COVID-19. However, it has yet to receive universal acceptance for the treatment of COVID-19. Chloroquine and Hydroxychloroquine seem to be effective in limiting the replication of SARS-CoV-2 virus in vitro. COVID-19 is highly pandemic in countries where malaria is least prevalent and least pandemic in countries where malaria is highly prevalent. These findings suggest the hypothesis that anti-malarial drugs have efficacy in the treatment of COVID-19.
Comparison between effects of reverse curve of Spee nickel titanium archwire and stainless steel archwires with and without torque on the lower incisors in deep overbite treatment: a randomized control study
Authors: Shakhtour Farah , Al-Nimri Kazem 
Published: September 2024

ABSTRACT

Objectives
To compare the effect between three different reverse curve of Spee (RCOS) archwires: 0.016 × 0.022-inch Nickel-Titanium and 0.019 × 0.025-inch stainless steel (SS) with and without crown labial torque (CLT) on lower incisors during deep overbite treatment.

Materials and Methods
Eighty subjects with deep overbite were randomly divided into three groups: the first group (mean age: 20.5 years) received SS RCOS with CLT, the second group (mean age: 19.4 years) was treated with 0.019 × 0.025-inch SS RCOS with zero CLT, the third group (mean age: 18.2 years) was treated with rocking-chair nickel-titanium (NiTi) 0.016 × 0.022-inch with RCOS. Two lateral cephalometric images were taken for each patient, one after alignment and the second after deep bite correction. These images were superimposed using the corpus axis to study the lower incisor horizontal and vertical changes.

Results
The lower incisor angular change was significantly smaller in Group II (−0.3°) compared to Group I (4.8°) and Group III (6.0°, P ≤ .001). Lower incisor anterior movement was reduced in Group II compared to Group I (P = .014) and Group III (P = .008). Group III showed significantly more downward movement of the lower Incisors (P ≤ .001). The three groups showed comparable amounts of true intrusion (1 mm, P = .536).

Conclusions
0.016 × 0.022-inch NiTi and 0.019 × 0.025-inch SS with crown labial torque RCOS archwires resulted in similar proclination and forward movement of the lower incisors. Removal of anterior crown labial torque from the 0.019 × 0.025-inch SS RCOS archwire prevents lower incisor proclination and forward movement.
Effectiveness of PBL Learning Model with Letter Card Interactive Media Approach in Improving Reading Skills of Grade II Learners in Elementary School
Authors: Azzahra Tasya Nur , Fatayan Arum 
Published: September 2024

Elementary schools still have many problems, such as the need for more effectiveness in using models and media to improve reading skills. This study aims to determine the efficacy of a problem-based learning model with a letter card interactive media approach in enhancing the reading skills of grade II students. Type of research: Pre-experiment with a quantitative approach. The research design is One Group Pretest-Postest. The population of this study was all grade II students; 28 students of class II A were selected using the nonprobability sampling technique, a purposive sampling approach. Pre-tests and post-tests were given to determine the level of reading skills. The data collected was processed by paired sample t-test and effect size because the data was expected. This study concludes that using a problem-based learning model with a letter card interactive media approach is practical enough to improve reading skills in grade II. The sig value. 0.000 <0.05 indicates a difference before and after treatment, and the effect size test result is 0.298 with a reasonably effective category. Therefore, it is stated that the initial hypothesis is rejected, and the alternative hypothesis is accepted.Keywords: Problem Based Learning, Letter Card, Reading Skills
Peran Kepemimpinan Kepala Sekolah Dalam Pengambilan Keputusan dan Pengaruhnya Terhadap Disiplin Kerja Guru Taman Kanak-kanak
Authors: Kamtini Kamtini , Zainuddin Zainuddin , Mudjisusatyo Yuniarto , Pangaribuan Wanapri 
Published: September 2024

Kepala sekolah memegang peran penting terhadap situasi pembelajaran di sekolah, hal tersebutdipengaruhi oleh bagaimana kemampuan kepala sekolah dalam pengambilan keputusan. Setiap pengambilan keputusan yang diambil oleh kepala sekolah dapat menentukan bagaimana warga sekolah khususnya guru untuk dapat menjalankan aturan- aturan yang tersedia, seperti kedisiplinan. Artikel ini menggunakan penelitian kualitatif dengan menggunakan dokumen referensi yang berkaitan dengan kepemimpinan kepala sekolah, pengambilan keputusan dan disiplin kerja guru.Keywords: Kepala Sekolah, Pengambilan Keputusan, Disiplin Guru
Penurunan Trigliserida dengan Suplemen Omega-3 pada Pasien Dislipidemia
Authors: Lorensia Amelia , Diputra I Nyoman Yoga 
Published: September 2024

Overweight dan obesitas terkait dengan berbagai penyakit pada sistem kardiovaskular, Trigliserida (TG) menjadi salah satu tanda klinis dari terjadi obesitas. Asam lemak omega-3 direkomendasikan untuk menurunkan TG pada hipertrigliseridemia. Tujuan penelitian adalah mengetahui efektifitas suplemen omega-3 dan menurunkan kadar TG pada dislipidemia. Rancangan penelitian yang digunakan adalah one grup pretest-posttest design, dengan menganalisa pemberian omega-3 dengan dosis 1 g/hari selama 4 minggu terhadap kadar TG pasien. Lokasi penelitian di sebuah rumah sakit di Sidoarjo, Jawa Timur, Indonesia, mulai bulan April-Agustus 2022. Variabel penelitian adalah suplemen omega-3 dan kadar TG. Responden adalah semua pasien dewasa dengan overweight/obesitas, yang menjalani rawat jalan di rumah sakit tersebut, dengan menggunakan teknik yaitu consecutive sampling dan purposive sampling. Analisa perbedaan kadar TG sebelum dan sesudah terapi suplemen omega-3 menggunakan uji t-test berpasangan (rasio) dan uji chi-square (ordinal). Jumlah responden yang terlibat dalam penelitian adalah 36 orang. Nilai Sig.(2-tailed) dengan nilai-P sebesar 0,421>0,05, yang berarti tidak ada perbedaan antara sebelum dan sesudah pemberian suplemen omega-3. Adanya kecenderungan penurunan kadar TG setelah pemberian suplemen omega-3 dan rata-rata penurunannya adalah 9,44 mg/dL. Oleh karena itu , perlu dianalisa lebih lanjut terhadap parameter lipid lainnya dan faktor-faktor yang mempengaruhi TG, seperti genetic dan indeks massa tubuh (IMT).
Studi Disolusi Terbanding dari Tablet Febuxostat dengan Variasi Perbandingan Konsentrasi Hidroksipropil Selulosa dan Natrium Kroskarmelos
Authors: Hambali Luthfi Fathiinah , Soewandhi Sundani Nurono , Satrialdi Satrialdi 
Published: September 2024

Febuxostat merupakan obat golongan anti asam urat, obat ini adalah turunan 2-arylthiazole yang bekerja dengan menurunkan kadar serum asam urat dengan penghambatan secara selektif pada xanthine oxidase (XO). Dalam beberapa penelitian yang telah dilakukan sebelumnya menunjukkan bahwa Febuxostat memiliki efikasi dan keamanan yang lebih baik dibandingkan Allopurinol. Febuxostat masih merupakan obat yang menjanjikan untuk dikembangkan di Indonesia dikarenakan berdasarkan data Badan Pengawas Obat dan Makanan (BPOM) hingga saat ini hanya terdapat 1 kompetitor obat copy generic berlogo yang beredar. Uji disolusi terbanding merupakan pengujian secara in vitro untuk membuktikan similaritas obat copy yang dibandingkan terhadap produk innovator, dimana similaritas tersebut merupakan salah satu syarat registrasi obat, suatu obat copy dinyatakan similar terhadap produk innovator bila hasil perhitungan F2 pada uji disolusi terbanding > 50%. Uji disolusi terbanding dilakukan pada 3 pH yaitu 1,2; 4,5; dan 6,8. Pada penelitian ini dilakukan pengembangan tablet Febuxostat dengan beberapa perbandingan konsentrasi hidroksipropil selulosa (HPS) dan natirum kroskarmelos (NKK). Desain percobaan dibuat dengan desain faktorial penuh menggunakan aplikasi Minitab 21. Konsentrasi hidroksipropil selulosa dioptimasi pada konsentrasi 3 dan 5% sedangkan natrium kroskarmelose dioptimasi pada konsentrasi 1 dan 4%. HPSNKKTujuan dari penelitian ini adalah menemukan kombinasi HPS HPSdanNKK NKK yang tepat, untuk menghasilkan produk tablet yang memenuhi uji disolusi terbanding pada ketiga pH. Berdasarkan hasil penelitian, konsentrasi HPSNKK HPS : NKK (3:1) menghasilkan uji disolusi terbanding yang similar di ketiga pH, dimana nilai similaritas pada pH 1,2; 4,5; dan 6,8 berturut-turut sebesar 65,62; 74,72; dan 80,82.
CHARACTERISTICS OF CHINA'S FOREIGN AFFAIRS REPORTS IN THE MATERIALS OF NEW YORK TIMES
Authors: Чэньжань Лю. 
Published: September 2024

Статья посвящена исследованию особенностей освещения внешней политики КНР в американской публикации New York Times. В эпоху все более тесных связей между различными странами развитие Китая привлекло внимание всего мира. Внешняя политика также больше не ограничивается политической областью, а пересекается со многими факторами. В настоящее время, когда информационная война стала важным средством политической игры, анализ освещения внешней политики Китая в ведущих американских СМИ позволяет лучше понять роль и влияние СМИ в международных отношениях.
HYDRONYMY OF LUGANSK REGION (GENERAL CHARACTERISTIC)
Authors: Брайловская Ю.П. 
Published: September 2024

В статье рассматриваются лексико-семантические аспекты наименований гидронимов Луганского края, с целью становления их общих признаков семантики. Актуальность заключается в том, что гидронимия Луганского края непосредственно никем не изучалась. Научная работа предполагает описание лексико-семантических групп гидронимов, их региональных особенностей.
PPROACHES TO THE DEFINITION OF THE CONCEPT FAKE NEWS APPLICABLE TO MASS COMMUNICATION
Authors: Свиридова А.А. 
Published: September 2024

Исследование посвящено изучению подходов к определению дефиниции «фейкньюс» (fake news) применительно к медиа и сетевому пространству. Рассмотрены взгляды многих отечественных и зарубежных исследователей (Верстраете М., Дерек Э. и Джейн Р. Бамбуэры, Ильченко С.Н., Распопова С.С., Суходолов А.П. и др.). На основе анализа автором предпринята попытка разграничения понятий «дезинформация» и «фейкньюс», отражающих подходы к изучению в научном дискурсе данного феномена. Вывод: на сегодняшний день в научном сообществе не сформировалось единого взгляда к определению фейкньюс» (fake news).
LEGAL DISCOURSE AS A SUBJECT OF SCIENTIFIC RESEARCH
Authors: Татуев А.Т. 
Published: September 2024

На основе проделанного обзора исследований, посвященных юридическому дискурсу нами сделан вывод, что по системообразующим признакам он относится к категории институциональных и его особенностью является отнесение к очень обширной многогранной денотативной области права, правоприменения и правового сознания, которая требует соблюдения строгой законности. Этот факт и определяет прагматико-коммуникативное использование языковых средств, отличающихся концептуальным, дискурсивным, стилистическим своеобразием.
Scaling Up Organic Agricultural Enterprises: An Empirical Study of the Role of Associations of Micro Producers
Authors: Božić Jasmina 
Published: September 2024

Abstract

Background
Development of organic agricultural entrepreneurship often requires “scaling up” from a multitude of individual, largely disconnected micro organic enterprises with haphazard achievements, toward more integrated units, operating more systematically and allowing for replication of their achievements on a larger territorial and temporal scale.

Objectives
The current states of activity, sectoral and inter-sectoral cooperation of Croatian associations of micro organic producers are assessed with a view to instigate and facilitate scaling up processes.

Methods/Approach
The inquiry is based on thematic analysis of qualitative data collected through semi-structured interviews with representatives of Croatian associations of micro organic producers.

Results
Lessening of tension between farmers’ strivings for autonomy and their need for mutual cooperation, trust in interpersonal relationships and organizational structures, and integration through value-based supply chains (VBSCs) are identified as important aspects of scaling-up.

Conclusions
Scaling-up processes are distinctly path-dependent and, although examples of earlier working practices are welcome, they can seldom be carbon copied in different developmental contexts. Conceptualization of scaling up as intensification of relational interdependencies among various organizational units at several levels of aggregation underlines the need for strengthening the role of associations of micro producers as intermediaries between family farms and other, more complex, inter-sectoral organizational forms.
Comparing the process of converting land use purposes between socio-economic regions in Vietnam from 2007 to 2020
Authors: Tuan Nguyen Tran 
Published: September 2024

Abstract
Reporting land use changes over time is important for evaluating land resource management. This study applied GIS technology to determine land use fluctuations for the entire mainland territory in Vietnam. In particular, the research focused on two main issues: (1) spatial fluctuations of some main land groups in Vietnam, and(2) the rate of land use change in socio-economic regions in the two periods 2007–2016 and 2016–2020. Research results showed that the Forests land group showed a growth of over 14% and spatial fluctuations took place in all regions, except for two regions with little change in this land group: Red River Delta (RRD) and Mekong River Delta (MRD). Meanwhile, crops decreased by over 16% from 2007–2020 and appeared heavily in the Northern Midlands and Mountains (NMR), North Central and Central Coast regions (NCR), and Central Highlands region (CHR). Urban land group increased by 3% during 2007–2020. The speed of land use conversion also showed different results between economic regions and inthe two research periods. The results showed that the recent research period witnessed a higher rate of land use conversion in the regions compared to the period 2007–2016. In particular, the NMR region showed that the conversion rate was the largest in both stages.
Beach and dune deposits on the Mediterranean coast of Andalusia (Spain) in the light of morphoscopic analysis of quartz grains
Authors: Dulias Renata 
Published: September 2024

Abstract
This work aimed to investigate the abrasion of quartz grains from beach and dune deposits on the Mediterranean coast of Andalusia. Five sites were established on the coasts of Malaga and Almeria provinces: Genoveses, Monsul, Carraca, Malagueta, and Artola. Grain size and mineral composition were determined for 15 samples taken from beaches (6) and dunes (9). Quartz abrasion was established using the morphoscopic method. Investigated deposits, with two exceptions, are primarily medium-grained and moderate sorting. The share of quartz is relatively small – in aeolian sands, it is on average 38.3% and is higher than in beach sands (average 26.4%). The average proportion of fresh and angular NU grains is significantly higher in aeolian sands (58.9%) than beach sands (43.4%), indicating morphoselection’s important role during wind transport. In beach sands, there are, on average, 32.4% of grains with aeolian abrasion (RM and EM/RM), which is twice as much as in dune sands (15.5%). The multiple predominances of EM/RM grains over RM grains indicate a relatively short aeolian activity.
Supply chain perspectives for achieving economic growth and environmental sustainability
Authors: Kovačič Lukman Rebeka , Brglez Kristijan , Fošner Maja 
Published: September 2024

Abstract
A resilient supply chain is crucial for economic growth and the well-being of economies. However, it contributes to environmental challenges, such as resource extraction, material usage, climate change and biodiversity. This Special Volume of the Journal of Logistics, Supply Chain, Sustainability, and Global Challenges explores current research directions and challenges while offering solutions for sustainable supply chains. The volume examines existing European policy directives and strategies to comprehensively understand sustainable supply chain requirements. It conducts a content analysis of the current research in the field. The authors present valuable theoretical insights and empirical case studies addressing the interplay between sustainable supply chains, economic growth, and environmental impact mitigation. The papers in this Special Volume highlight the holistic and interconnected nature of the supply chain field and emphasise that there is still significant potential for improving supply chain processes to enhance their sustainability.
4E Analysis of solar photovoltaic, wind, and hybrid power systems in southern Pakistan: energy, exergy, economic, and environmental perspectives
Authors: Uzair Yousuf Muhammad , Malik Muhammad Hamza , Umair Muhammad 
Published: September 2024

Pakistan faces significant challenges in its energy sector, including a persistent supply-demand gap and heavy reliance on imported fossil fuels, leading to high costs, environmental degradation, and energy insecurity. This study examines the potential of solar Photovoltaic Systems (PVS), Wind Turbine Systems (WTS), and solar Photovoltaic and Wind Turbine Hybrid Systems (PVWHS) in the southern region of Pakistan through a comprehensive 4E analysis, encompassing energy, exergy, economic, and environmental perspectives. Initially, the data on Global Horizontal Irradiation (GHI) was sourced from Meteonorm, while wind data was obtained from the Energy Sector Management Assistance Program of the World Bank. A hypothetical 50 MW powerplant is considered in this study. For PV potential, PVsyst software is utilized to simulate various panels from Tier-1 Photovoltaic (PV) manufacturers covering mono-Si, poly-Si, and thin-film (Cd–Te) technologies. For wind system analysis, Google Earth Pro is used to design the wind farm layout, and the PyWake library is utilized to evaluate the wind system performance and energy generation. In this study, the Bastankhah wake deficit model, along with the weighted sum superposition model, is applied to assess the wind turbine performance. The remaining analyses, including exergy, economic, and environmental assessments, are conducted using MATLAB and Excel. All four sites – Tando-Ghulam Ali, Sanghar, Sujawal, and Umerkot – demonstrated promising energy generation capacities for solar PVS, WTS, and PVWHS. Tando Ghulam Ali emerges as the optimal site with thin-film PVS systems exhibiting the lowest Levelized Cost of Energy (LCOE) and significant Net Present Value (NPV). A weighted score analysis using the Factor Rating Method (FRM) identifies a 40 MW PVS and 9 MW WTS combination as the most feasible mix, offering substantial energy generation and carbon emissions reduction benefits. These findings provide actionable insights for stakeholders and policymakers aiming to enhance renewable energy adoption in Pakistan.
Brain Cancer Treatment with Gene Editing
Authors: Qiu Zihan , Liu Chunjing 
Published: September 2024

The first method is used gene editing to knock out the PD-L1 receptor located on the T cell surface so that PD-1 on the cancer cell surface cannot combine with the PD-L1, in that case, T cell can identify the abnormal cell and kill it. At the beginning, researchers use protein-guided editing technology, but it is not easy to control and not specific enough, so they choose to use CRISPR-Cas9 to edit the target gene. Comparing with the traditional protein-guided nucleases, CRISPR-Cas9 system is more easy-handle, highly specific, and it is an more efficient tool for engineering eukaryotic genomes; because CRISPR-Cas9 system aims to edit the targeting genes by tiny RNAs guiding the Cas9 nuclease to the target site by base pairing.The second treatment is mainly used “fighting cancer with cancer”.Because living tumor cells have the ability to home and target tumors, thus, if those living tumor cells can be engineered to secrete therapeutic agents, the tumor cells can be effectively cured. Shah’s team picked the agent interferon-β (IFN-β). However, this idea of treatment is limited by the premature cell death due to autocrine toxicity.The researchers solved this problem by first using CRISPR Cas9 to knock out the IFN-β–specific receptor (IFNAR1) in inherently IFN-β–sensitive syngeneic tumor cells, and subsequently engineered them to constitutively produce IFN-β for tumor cell targeting and simultaneous immunomodulation. These therapeutic cells are further designed to coexpress granulocyte-macrophage colony-stimulating factor (GM-CSF) that facilitates the differentiation, proliferation, and recruitment of dendritic cells (DCs). The last approach can stop cancer cell repairing their DNA when it gets damaged.