bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of cellular thermal shift assay (CETSA) to study Crizotinib resistance in ALK-expressing human cancers
Authors: Alshareef Abdulraheem , Zhang Hai-Feng , Huang Yung-Hsing , Wu Chengsheng , Zhang Jing Dong , Wang Peng , El-Sehemy Ahmed , Fares Mohamed , Lai Raymond 
Published: September 2016

AbstractVarious forms of oncogenic ALK proteins have been identified in various types of human cancers. While Crizotinib, an ALK inhibitor, has been found to be therapeutically useful against a subset of ALK+ tumours, clinical resistance to this drug has been well recognized and the mechanism of this phenomenon is incompletely understood. Using the cellular thermal shift assay (CETSA), we measured the Crizotinib—ALK binding in a panel of ALK+ cell lines, and correlated the findings with the ALK structure and its interactions with specific binding proteins. The Crizotinib IC50 significantly correlated with Crizotinib—ALK binding. The suboptimal Crizotinib—ALK binding in Crizotinib-resistant cells is not due to the cell-specific environment, since transfection of NPM-ALK into these cells revealed substantial Crizotinib—NPM-ALK binding. Interestingly, we found that the resistant cells expressed higher protein level of β-catenin and siRNA knockdown restored Crizotinib—ALK binding (correlated with a significant lowering of IC50). Computational analysis of the crystal structures suggests that β-catenin exerts steric hindrance to the Crizotinib—ALK binding. In conclusion, the Crizotinib—ALK binding measurable by CETSA is useful in predicting Crizotinib sensitivity, and Crizotinib—ALK binding is in turn dictated by the structure of ALK and some of its binding partners.
Direct Tumor Embolization of Sinonasal Unclassified Spindle Cell Sarcoma with Onyx
Authors: Srinet Prateek , Manes Richard Peter , Kansal Ankit 
Published: September 2016

Objectives To evaluate the use of a new tumor embolization agent, Onyx (Covidien, Dublin, Ireland), for the use of intraoperative embolization of a sinonasal unclassified spindle cell sarcoma.
Methods A 45-year-old female patient presented to the rhinology clinic with a nasal mass. A biopsy revealed a highly vascular mass consistent with a sinonasal unclassified spindle cell sarcoma. Secondary to its extensive vascularity, the patient underwent preoperative transarterial embolization (TAE) before definitive resection. Due to complex vascular anatomy including feeding vessels emanating from intracranial circulation, incomplete embolization was achieved. Subsequently, intraoperative embolization with Onyx at the time of resection was performed.
Results Intraoperative Onyx use resulted in almost complete devascularization of the tumor with decreased risk of intracranial embolization.
Conclusions Intraoperative embolization with Onyx after an incomplete TAE can be a safe and effective method of achieving near-total embolization of sinonasal tumors.
Risiken und präventive Maßnahmen angesichts der Sonnenfinsternis März 2015
Authors: Tsatsos M. , MacGregor C. , Gousia D. , Moschos M. , Detorakis E. 
Published: September 2016

ZusammenfassungDie Sonnenfinsternis ist ein beeindruckendes Naturphänomen, welches in Europa zuletzt 2006 erlebt wurde. Am 20. März 2015 konnte eine Sonnenfinsternis in einem großen Teil Europas beobachtet werden. Ohne geeigneten Augenschutz sollte jedoch eine Sonnenfinsternis nicht betrachtet werden, da dadurch Solarretinopathie verursacht werden kann. Die öffentliche Bildung über das Verhalten bei einer Sonnenfinsternis zeigt sich intensiver. In dieser Studie wurden die Aufklärungskampagnen von Zeitungen vor der letzten Sonnenfinsternis in verschiedenen EU-Ländern miteinander verglichen.
Methoden: 31 Onlinezeitungsausgaben aus 6 Ländern, in denen die Sonnenfinsternis am meisten sichtbar war, wurden geprüft. Die Aufklärung über das Solarretinopathierisiko, die Methoden einer sicheren Beobachtung und die sichere Anwendung der neuen Technologien wurden bewertet.
Ergebnisse: In allen geprüften Zeitungen wird die Sonnenfinsternis erwähnt sowie die damit verbundene Gefahr für die Sehkraft und verschiedene Augenschutzmethoden. Von den meisten Zeitungen werden Sonnensichtbrillen empfohlen. Die Hinweise auf die Schutzmaßnahmen für Kinder als Hochrisikogruppe sind zwischen den Ländern unterschiedlich.
Diskussion: Die Aufklärung seitens der Medien hat sich seit der Sonnenfinsternis von 2006 intensiviert. Die Augenschutzmethoden haben sich die letzten Jahre nicht geändert, neue Technologien, wie Handy-Kameras und der Selfie-Trend, können jedoch das Risiko einer Solarretinopathie erhöhen.
Prävalenz erhöhter Lipoprotein(a)-Spiegel bei unter 60-jährigen Patienten mit venösen retinalen Gefäßverschlüssen
Authors: Kuhli-Hattenbach C. , Hellstern P. , Miesbach W. , Kohnen T. , Hattenbach L.-O. 
Published: September 2016

Zusammenfassung
Hintergrund: Die Bedeutung einer Lipoprotein(a)-Erhöhung [Lp(a)] im Hinblick auf Alter und andere Risikofaktoren für die Entstehung venöser retinaler Gefäßverschlüsse wurde bisher wenig untersucht.
Patienten und Methoden: In einer retrospektiven Fall-Kontroll-Studie verglichen wir die Ergebnisse eines umfassenden Thrombophiliescreenings von 106 jungen Patienten mit venösen retinalen Gefäßverschlüssen (< 60 Jahre zum Zeitpunkt der Erkrankung oder eines früheren thromboembolischen Ereignisses) mit denen von 76 gesunden Probanden.
Ergebnisse: 31 der 106 (29,2 %) Patienten wiesen eine Lp(a)-Erhöhung auf verglichen mit 7 der 76 (9,2 %) gesunden Probanden (p = 0,0009). Die durchschnittlich gemessenen Lp(a)-Spiegel waren in der Patientengruppe signifikant höher als in der gesunden Vergleichsgruppe (p = 0,012). Innerhalb der Patientengruppe beobachteten wir eine signifikante Assoziation von Lp(a) mit einer auffälligen Eigen- oder Familienanamnese hinsichtlich thromboembolischer Ereignisse (p = 0,03). Darüber hinaus zeigte sich innerhalb der Patientengruppe eine Lp(a)-Erhöhung signifikant häufiger in Kombination mit zusätzlichen thrombophilen Risikofaktoren als in der Vergleichsgruppe (p = 0,005). Die logistische Regression mit Abbau bestätigte Lp(a) als unabhängigen Risikofaktor für die Entstehung venöser retinaler Gefäßverschlüsse (p = 0,003).
Schlussfolgerung: Unsere Ergebnisse weisen darauf hin, dass erhöhten Lp(a)-Spiegeln bei jungen Patienten mit venösen retinalen Gefäßverschlüssen eine pathogenetische Bedeutung zukommt. Eine positive Eigen- oder Familienanamnese hinsichtlich thromboembolischer Ereignisse weist signifikant häufiger auf diesen genetisch determinierten Parameter hin.
Brand management in a situation of an economic crisis
Authors: Drewniak Rafał , Karaszewski Robert 
Published: September 2016

Purpose
The purpose of this paper is to present modern marketing tools used by today’s businesses to maintain or strengthen the value of their brands in the conditions of deteriorating economic situation. The specific purpose is an analysis of activities that might be attempted by companies in emerging markets in order to increase the strength of their brands.

Design/methodology/approach
The paper presents the determinants of the development of brand value. An analysis has also been made of activities connected with the development of the brand based on the experience of the best brands in the world. Considerations are based on secondary sources, from national and international journals, books, magazines and specialist reports, as well as were supported by research results of the most valuable brands in the world.

Findings
The paper provides the insight of marketing activities, that may favor building brand value in the time of recession. It was suggested that recession may be a good time for some companies to invest in the brand. However, today’s competition conditions are forcing companies to used more modern marketing techniques in order to build a positive brand image. In addition, customers increasingly expect to be able to engage in brand and wish to influence its image.

Practical implications
The paper includes implications for companies in emerging markets, through which it is possible to effectively manage brand value in the time of crisis. These proposals are an important course of action for companies from emerging markets, which tend to increase the strength of its brand.

Originality/value
Due to the fact that the considerations in the paper relate to general proposals for action, the results can constitute a starting point for in-depth research in the future. An interesting issue would be to assess the effectiveness of the proposed activities in emerging markets.
The impact of country-of-origin image on brand loyalty: evidence from Iran
Authors: Esmaeilpour Fariba , Abdolvand Mohammad Ali 
Published: September 2016

Purpose
The purpose of this paper is to examine the effects of country-of-origin (COO) image on brand attitude and brand loyalty of Generation Y’s consumers toward two categories of luxury fashion brands.

Design/methodology/approach
First, a structural equation modeling method was employed based on data collected from 419 individuals born between 1977 and 1994 in Iran. In next steps, analysis was conducted using hierarchical regression analysis with a two-way interaction and a slope analysis. Watches and sunglasses are two luxury product categories chosen in this study.

Findings
The findings of the study reveal that consumers’ perception from COO technology advancement is the determinant of attitude toward luxury brands. COO technology advancement also, mediated by brand attitude, has an indirect positive effect on luxury brand loyalty. Moreover, the interaction between COO technology advancement and product-origin congruency has a significant and positive effect on consumers’ brand attitude.

Originality/value
This study has tried to investigate the impact of the constructs of the COO image on attitude and loyalty toward luxury brands in Generation Y. It has also dealt with the effect of product-origin congruency on the relationship between each one of the constructs of the COO image and brand attitude.
Construction by Contour Crafting using sulfur concrete with planetary applications
Authors: Khoshnevis Behrokh , Yuan Xiao , Zahiri Behnam , Zhang Jing , Xia Bin 
Published: September 2016

Purpose
This paper aims to report on the experiments with the Contour Crafting Automated Construction process using sulfur concrete as the choice of construction material.

Design/methodology/approach
Several experiments have been performed at centimeter and meter scales. A finite element analysis simulation model for the behavior of sulfur concrete-based structures has been developed. Experimental results were compared with the results of simulation.

Findings
Sulfur concrete has numerous terrestrial applications and is potentially an ideal construction material for planetary construction.

Originality/value
Experimental samples of sulfur concrete were fabricated using a novel mixer/extrusion system. The mechanism was proven to be durable and stable after more than 500 h of work.
Designing passive dynamic walking robots for additive manufacture
Authors: Stöckli Fritz , Modica Fabio , Shea Kristina 
Published: September 2016

Purpose
Ongoing research in computational design synthesis of passive dynamic systems aims to automatically generate robotic configurations based on a given task. However, an automated design-to-fabrication process also requires a flexible fabrication method. This paper aims to explore designing and fabricating passive dynamic walking robots and all necessary components using single-material fused deposition modeling (FDM). Being able to fabricate all components of a robot using FDM is a step toward the goal of automated design and fabrication of passive dynamic robots.

Design/methodology/approach
Two different configurations of passive dynamic walking robots are re-designed to be fabricated using FDM. Different robotic joint assemblies are designed and tested. To arrive at feasible solutions, a modular design approach is chosen and adjustability of components after printing is integrated in the design.

Findings
The suitability of FDM for printing passive dynamic robots is shown to depend heavily on the sensitivity of the configuration. For one robot configuration, all components are printed in one job and only little assembly is needed after printing. For the second robot configuration, which has a more sensitive gait, a metal bearing is found to increase the performance substantially.

Originality/value
Printable, monolithic mechatronic systems require multi-material printing, including electronics. In contrast, passive dynamic systems not only have the potential to save energy and component cost compared to actuated systems but can also be fabricated using single-material FDM as demonstrated in this paper.
Public spaces protection orders – an “attack of vagueness”
Authors: O’Brien Brendan 
Published: September 2016

Purpose
The purpose of this paper is to highlight legislative and procedural problems with the implementation across England and Wales of Public Spaces Protection Orders (PSPOs).

Design/methodology/approach
Through a review of current and planned PSPOs across England and Wales.

Findings
A patchwork quilt of unenforceable and vague legislation will only cause enforcement agencies to become confused and for potentially innocent people to be convicted.

Originality/value
The author does not believe any similar papers have been published.
The anti-social behaviour, crime and policing act in practice – a practitioner perspective
Authors: Varley Kirsty 
Published: September 2016

Purpose
The purpose of this paper is to offer a practitioner’s perspective to the Anti-Social Behaviour Crime and Policing Act 2014. Many of the new sections are now in force and three in particular have been of interest to me in the last 12-18 months.

Design/methodology/approach
The paper is written on the basis of the author’s own knowledge, experience and cases that the author has dealt with under the new legislation. Where cases have been published the author has included the relevant links to press coverage.

Findings
The financial limitations upon registered provides of social housing (RPs) will affect the way in which they conduct litigation and so might mean that RPs are less likely to want to take risks in court. The new grounds have not faced meaningful challenge yet, and so their use might be limited until case law is developed and settled to provide more certainty in this area.

Originality/value
The perspective is the author’s own and has been written solely by the author for this specific purpose. It is hoped that this will offer insight into the development of anti-social behaviour/housing law and how practitioners view the changes now that they are in force.
Jumping Together: A Fatal Suicide Pact
Authors: Sikary Asit Kumar , Swain Rajanikanta , Dhaka Shivani , Gupta Sudhir K , Yadav Abhishek 
Published: September 2016

AbstractIn suicide pact, two or more victims mutually agree and execute to end their lives together by predetermined method, preferably by hanging, drowning, gunshot, or poisoning. The victims are usually spouses, lovers, or friends, and the reasons behind such steps are various. In this reported suicide pact, husband–wife duo jumped from the terrace of a 12‐meter‐high building with their wrist bound to each other. Although they jumped together, the injury patterns were completely different. The man landed on head sustaining mainly craniocerebral injuries, and the wife landed on feet sustaining long bone injuries. They left a suicide note pointing out sudden demise of their only child as the reason for the suicide, and it was signed by both of them. Jumping from a height in suicide pact has not been reported in the scientific literature yet.
Ricochet Behavior on Glass—Critical Ricochet Angles, Ricochet Angles, and Deflection Angles
Authors: Mattijssen Erwin J. A. T. , Pater K. Dieter H. , Stoel Reinoud D. 
Published: September 2016

AbstractFor shooting scene reconstruction purposes, knowledge about the ricochet behavior of bullets provides valuable information. In this study, the critical ricochet angles of four cartridge types were established on plain float glass. The estimates of the critical ricochet angles varied between cartridge types and were 21.0° for .32 Auto FMJ bullets, 15.8° for 9 mm Luger FMJ bullets, 17.6° for .45 Auto FMJ bullets, and 21.3° for 9 mm Luger, Action NP bullets. The corresponding ricochet and deflection angles per incidence angle varied depending on the state of the ricocheted bullets. The mean ricochet angles are always lower than the corresponding angles of incidence, and the mean ricochet angles for the FMJ bullets with undamaged jackets are lower than those of bullets where the jacket is either damaged or the bullet partially ricocheted and partially perforated. Mean ricochet angles are lower for undamaged FMJ bullets than for undamaged Action NP bullets.
Using RNA‐Seq SNP data to reveal potential causal mutations related to pig production traits and RNA editing
Authors: Martínez‐Montes A. M. , Fernández A. , Pérez‐Montarelo D. , Alves E. , Benítez R. M. , Nuñez Y. , Óvilo C. , Ibañez‐Escriche N. , Folch J. M. , Fernández A. I. 
Published: September 2016

SummaryRNA‐Seq technology is widely used in quantitative gene expression studies and identification of non‐annotated transcripts. However this technology also can be used for polymorphism detection and RNA editing in transcribed regions in an efficient and cost‐effective way. This study used SNP data from an RNA‐Seq assay to identify genes and mutations underlying production trait variations in an experimental pig population. The hypothalamic and hepatic transcriptomes of nine extreme animals for growth and fatness from an (Iberian × Landrace) × Landrace backcross were analyzed by RNA‐Seq methodology, and SNP calling was conducted. More than 125 000 single nucleotide variants (SNVs) were identified in each tissue, and 78% were considered to be potential SNPs, those SNVs segregating in the context of this study. Potential informative SNPs were detected by considering those showing a homozygous or heterozygous genotype in one extreme group and the alternative genotype in the other group. In this way, 4396 and 1862 informative SNPs were detected in hypothalamus and liver respectively. Out of the 32 SNPs selected for validation, 25 (80%) were confirmed as actual SNPs. Association analyses for growth, fatness and premium cut yields with 19 selected SNPs were carried out, and four potential causal genes (RETSAT, COPA, RNMT and PALMD) were identified. Interestingly, new RNA editing modifications were detected and validated for the NR3C1:g.102797 (ss1985401074) and ACSM2B:g.13374 (ss1985401075) positions and for the COG3:g3.4525 (ss1985401087) modification previously identified across vertebrates, which could lead to phenotypic variation and should be further investigated.
ASXL1 and JAK2V617F gene mutation screening in Iranian patients with chronic myeloid leukemia
Authors: Valikhani Amir , Poopak Behzad , Ferdowsi Shirin , Azizi Tabesh Ghasem , Ghaffari Seyed H , Saraf Kazeruoni Ehsan , Rezaei Negar , Farshchi Alireza , Amirizadeh Naser 
Published: September 2016

AbstractAimIn recent years, a few cases of chronic myeloid leukemia (CML) have been reported with both BCR‐ABL and JAK2V617F mutations. Moreover, mutations in the additional sex comb‐like 1 (ASXL1) gene were recently shown in various myeloid malignancies.There were no previous studies investigating the incidence of the ASXL1 and JAK2V617F mutations in Iranian patients with CML. Consequently, this study focuses on the analysis of these mutations in patients with CML.MethodsIn total, 66 patients with a clinical diagnosis of CML were examined at the time of diagnosis. Thirty healthy subjects were checked as controls. Exon 12 of ASXL1 was amplified from genomic DNA and bidirectionally sequenced. We also performed JAK2V617F screening by amplification refractory mutation system‐polymerase chain reaction and sequencing.ResultsMutations in the ASXL1 gene were found in five out of 66 CML patients (7.6%). We identified a novel variant (c.1968G > A, p.Asp656Asn) in one of the patients that has not been reported before. We also identified BCR‐ABL and JAK2V617F mutations simultaneously in four patients (6%).ConclusionOur demonstration of ASXL1 mutation, a putative tumor suppressor gene, represents an important molecular abnormality in CML. We also showed that concomitant detection of BCR‐ABL and JAK2V617F mutations has a relatively high incidence in Iranian patients.
Global fishing capacity and fishing effort from 1950 to 2012
Authors: Bell Justin D , Watson Reg A , Ye Yimin 
Published: September 2016

AbstractGlobal marine wild‐capture landings have remained relatively stable for >20 years; however, there is a lack of credible fishing capacity and effort information required to assess the sustainability and efficiency of the global fleet. As such, we estimated global fishing capacity and effort from 1950 to 2012 using a relatively comprehensive database developed by the FAO, supplemented by other data sources. Using random sampling techniques, we estimated the uncertainty surrounding many of our estimates enabling the identification of deficiencies and limitations. Global fishing capacity and effort increased rapidly from the late 1970s through to around 2010 before stabilizing. The Asian fleet is more than an order of magnitude larger than any other region in both capacity and effort, and continues to increase. Most other regions have stabilized, and there have been considerable declines in Europe and, to a lesser extent, in North America. Developed nations, as a whole, have decreased in both measures in the recent years and are responsible for the stabilization of the global trend. Developing and undeveloped countries are still increasing with the former having the largest fleet and showing the greatest relative increase with the socioeconomic impacts of reversing these trends likely to be high. The efficiency of the global fleet, in terms of watt days of fishing effort per tonnage of wild marine catch, is now less than in 1950 despite the considerable technological advances, and expansion throughout the world's oceans, that has occurred during this period of time.