bluuebunny/crossref_metadata_2025_split huggingface dataset:
An ancient FMRFamide-related peptide-receptor pair induces defense behavior in a brachiopod larva
Authors: Thiel Daniel , Bauknecht Philipp , Jékely Gáspár , Hejnol Andreas 
Published: March 2017

AbstractAnimals show different behaviors that can consist of various spatially or temporally separated sub-reactions. Even less complex organisms, like ciliated larvae that display important behaviors (e.g. metamorphosis, defense, feeding), need to coordinate coherent sub-reactions with their simple nervous system. These behaviors can be triggered by neuropeptides, which are short signaling peptides. Despite the high diversity of neuropeptides in animals, and although their immunoreactivity is widely used in morphological studies of animal nervous systems (e.g. FMRFamide), their function and role in trochozoan larval behavior has so far only been tested in a few cases. When mechanically disturbed, the planktonic larvae of the brachiopodTerebratalia transversaprotrude their stiff and pointy chaetae in a defensive manner and sink down slowly: a startle reaction that is known from different chaetous trochozoan larvae. We found that both of these reactions can be induced simultaneously by the FMRFamide-related neuropeptide FLRFamide. We deorphanized theTerebrataliaFLRFamide receptor and found its expression spatially separated in the apical lobe at the prototroch of the larvae and in the trunk musculature, which correlates with the tissues that are responsible to perform the two sub-reactions. A behavioral assay showed a decreasing efficiency of modified peptides in triggering this behavior, which correlates with the decreasing efficiency of activating the FLRFamide receptor in transfected CHO-K1 cells. Immunohistochemistry andin situhybridization show FLRFamidergic neurons in the apical lobe as well as next to the trunk musculature. Our results show that the single neuropeptide FLRFamide can specifically induce the two coherent sub-reactions of theT. transversastartle behavior.
IT usage for enhancing trade show performance: evidence from the aviation services
Authors: Singh Jaywant , Shukla Paurav , Kalafatis Stavros P. 
Published: March 2017

Purpose
While trade shows remain an important customer relationship management (CRM) tool, recent advancements in information technology (IT) have raised concerns about the future of trade shows. This study aims to examine the antecedents and consequences of IT integration into trade shows.

Design/methodology/approach
The study uses a questionnaire-based survey with senior and middle managers in the aviation services, resulting in 135 valid responses from industry professionals. The data were analyzed using partial least squares structural equation modelling.

Findings
The findings demonstrate differential but significant impact of perceptions toward website design and firm motivations toward the integration IT in the three stages of trade shows marketing. The results also show significant impact of IT usage on the perceptions toward the accomplishment of trade show objectives. Further, the results vary according to the levels of experience of the professionals.

Research limitations/implications
This study did not account for the differences in perceptions toward IT implementation across personnel from different departments, such as IT, finance and operations management. In addition, it did not examine situational factors and individual characteristics as additional antecedents of IT usage in trade shows, including pricing, return on investment, convenience and the social media.

Practical implications
Exhibitors are advised to integrate IT in supporting pre-trade show activities to approach potential customers. Exhibitors should integrate electronic interactions and personal communications during the show to reduce the amount of unanswered customer queries, focusing on timeliness and accuracy of information content, ease of navigation and graphic attractiveness of corporate websites, as effective CRM tools.

Originality/value
This paper offers novel insights into hitherto unknown aspects of trade show performance. The results have managerial implications for adopting IT as a CRM tool for effective trade show management.
Exploring Big Five personality traits and gender as predictors of entrepreneurs’ cognitive adaptability
Authors: Bajwa Sami Ullah , Shahzad Khuram , Aslam Haris 
Published: March 2017

PurposeThe purpose of this study was to explore the predictive role of personality and gender in cognitive adaptability of entrepreneurs. By using the theories of personality development, social learning, situated cognition and meta-cognition, a logical relationship between personality traits, gender difference and entrepreneurs’ cognitive adaptability was established.Design/methodology/approachQuantitative strategy and cross-sectional survey method was then deployed to empirically investigate the purposed relationships between variables of interest. Randomly selected 443 working entrepreneurs responded to the survey.FindingsFactor analyzed structural equation modeling estimated cognitive adaptability as a second-order factor, with extroversion and neuroticism having a significant impact on cognitive adaptability. Multi-group moderation revealed a significant difference among females and males against the same two personality traits.Originality/valueThis study in its nature is the first attempt to link Big Five personality traits with cognitive adaptability of entrepreneurs.
Categorizing product attributes efficiently in QFD-Kano: a case analysis in telecommunication
Authors: Suef Mokh , Suparno Suparno , Singgih Moses Laksono 
Published: March 2017

Purpose
The purpose of this paper is to propose a methodology to use complaints, claims and company innovation as an internal data source of customer needs for product development using the quality function deployment (QFD)-Kano approach instead of an ordinary customer survey.

Design/methodology/approach
This paper confirms that the customer complaints and claims and company innovations from the internal data source are equivalent to the Kano model’s product attributes. Data were selected from the company’s documents. To investigate the data category, a Kano questionnaire was designed and tested with 100 random respondents. Based on their answers, categories for the quality characteristics were determined and compared with the initial data categories. A second survey using professional customer respondents was conducted to increase the results’ reliability.

Findings
The approach was shown to be effective in employing complaints, claims and innovations as an alternative source of customer needs in the QFD-Kano approach.

Research limitations/implications
It is assumed that companies document their customer complaints and claims, as well as their strategic innovation plans. The complaint and claim data need to be extracted to reveal their quality characteristics. For future research, data extraction using text or data mining may be useful to bridge this gap.

Practical implications
The product development team may ascertain customer needs as duly classified. This voice of the customer is more accurate and requires less time.

Originality/value
The paper may be of value to researchers and practitioners involved in product design and development, since it offers a new source of customer need data obtained internally as an alternative to customer surveys.
TQM implementation in a least developed country: an exploratory study of Yemen
Authors: Aamer Ammar Mohamed , Al-Awlaqi Mohmmed A. , Alkibsi Sharaf M. 
Published: March 2017

Purpose
The purpose of this paper is to assess the TQM readiness level of Yemeni Organizations. In addition, this study compares the level of readiness between the various Yemeni organizations.

Design/methodology/approach
Based on the TQM literature, related and relevant information had been gathered to develop an assessment tool used in this research. The main content of the assessment focused on statements related to the most common TQM principles. Data were collected by an assessment team and analyzed using quantitative methods to answer the related research questions.

Findings
The analysis results showed some of the TQM principles were being practiced by Yemeni organizations, to some extent, and with variant levels. The most widely practiced principle was customer focus, and the lowest principle practiced was continuous improvement. Also, the data showed the level of TQM readiness in Yemeni organizations was 58.93 percent. This level of TQM readiness indicates there is a potential for successful adoption of quality management standards and models in Yemeni organizations.

Research limitations/implications
This study extends previous limited research in TQM readiness level measurement. It also adds to the body of TQM knowledge within the context of Yemen. In addition, this study contributes to the understanding of TQM implementation in an least developed countries (LDC) environment, where LDC organizational culture has its particularities on implementing TQM.

Originality/value
This paper contributes to a better understanding of TQM in an LDC country, which is Yemen. The paper points out which of the TQM principles are important to potential adoption of quality management standards and models. This study could further expand research, regarding the TQM in Yemen.
Sliding on the surface: bacterial spreading without an active motor
Authors: Hölscher Theresa , Kovács Ákos T. 
Published: March 2017

SummaryBacteria are able to translocate over surfaces using different types of active and passive motility mechanisms. Sliding is one of the passive types of movement since it is powered by the pushing force of dividing cells and additional factors facilitating the expansion over surfaces. In this review, we describe the sliding proficient bacteria that were previously investigated in details highlighting the sliding facilitating compounds and the regulation of sliding motility. Besides surfactants that reduce the friction between cells and substratum, other compounds including exopolysaccharides, hydrophobic proteins, or glycopeptidolipids where discovered to promote sliding. Therefore, we present the sliding bacteria in three groups depending on the additional compound required for sliding. Despite recent accomplishments in sliding research there are still many open questions about the mechanisms underlying sliding motility and its regulation in diverse bacterial species.
Physiological and proteomic characterization of light adaptations in marine Synechococcus
Authors: Mackey Katherine R. M. , Post Anton F. , McIlvin Matthew R. , Saito Mak A. 
Published: March 2017

SummaryMarine Synechococcus thrive over a range of light regimes in the ocean. We examined the proteomic, genomic and physiological responses of seven Synechococcus isolates to moderate irradiances (5–80 μE m−2 s−1), and show that Synechococcus spans a continuum of light responses ranging from low light optimized (LLO) to high light optimized (HLO). These light responses are linked to phylogeny and pigmentation. Marine sub‐cluster 5.1A isolates with higher phycouribilin: phycoerythrobilin ratios fell toward the LLO end of the continuum, while sub‐cluster 5.1B, 5.2 and estuarine Synechococcus with less phycouribilin fell toward the HLO end of the continuum. Global proteomes were highly responsive to light, with > 50% of abundant proteins varying more than twofold between the lowest and highest irradiance. All strains downregulated phycobilisome proteins with increasing irradiance. Regulation of proteins involved in photosynthetic electron transport, carbon fixation, oxidative stress protection (superoxide dismutases) and iron and nitrogen metabolism varied among strains, as did the number of high light inducible protein (Hlip) and DNA photolyase genes in their genomes. All but one LLO strain possessed the photoprotective orange carotenoid protein (OCP). The unique combinations of light responses in each strain gives rise to distinct photophysiological phenotypes that may affect Synechococcus distributions in the ocean.
The Syrian Humanitarian Disaster: Understanding Perceptions and Aspirations in Jordan, Lebanon and Turkey
Authors: Chatty Dawn 
Published: March 2017

AbstractThe modern architecture of international humanitarian assistance has established a template of provisioning for refugees fleeing armed conflict which is based on notions of encampment and vulnerability. The narrowness of that assistance framework coupled with an unsustainable policy of regional containment have created greater poverty and misery for Syrians fleeing the armed conflict in their country. How this has been allowed to happen on the eastern shores of the Mediterranean Sea – where extraordinary social linkages and networks have existed for centuries – lies mainly in the disparities between perceptions, aspirations and behaviour among refugees, practitioners and policy makers in Jordan, Lebanon and Turkey.
Humanitarian Rescue/Sovereign Capture and the Policing of Possible Responses to Violent Borders
Authors: Pallister‐Wilkins Polly 
Published: March 2017

AbstractPractices of rescue and assistance based on humanitarian concerns for life have increasingly come to shape both state and non‐state action that responds to the mobility of people on the move at the borders of Europe. These processes of rescue are presented as counter to processes of border control concerned with preventing and policing migratory flows. Presented and articulated as an alternative response to the increasingly restrictive and militarised practices that make‐up ‘Fortress Europe’, this humanitarian intervention concerned with saving lives both masks the violence of the border that renders people vulnerable in the first instance and masks the intimate relationship practices of rescue have with processes of capture more traditionally associated with border policing. The ascendancy of rescue as the primary response to irregular mobility also works to police the boundaries of what is considered ethical politics and the possible responses that result. Rescue does this through framing such events as unforeseen tragedies, erasing the structures of the violent border in the process and rendering counter‐narratives mute.
Reversal of hepatorenal syndrome type 1 with terlipressin plus albumin vs. placebo plus albumin in a pooled analysis of the OT‐0401 and REVERSE randomised clinical studies
Authors: Sanyal A. J. , Boyer T. D. , Frederick R. T. , Wong F. , Rossaro L. , Araya V. , Vargas H. E. , Reddy K. R. , Pappas S. C. , Teuber P. , Escalante S. , Jamil K. 
Published: March 2017

SummaryBackgroundThe goal of hepatorenal syndrome type 1 (HRS‐1) treatment is to improve renal function. Terlipressin, a synthetic vasopressin analogue, is a systemic vasoconstrictor used for the treatment of HRS‐1, where it is available.AimTo compare the efficacy of terlipressin plus albumin vs. placebo plus albumin in patients with HRS‐1.MethodsPooled patient‐level data from two large phase 3, randomised, placebo‐controlled studies were analysed for HRS reversal [serum creatinine (SCr) value ≤133 μmol/L], 90‐day survival, need for renal replacement therapy and predictors of HRS reversal. Patients received intravenous terlipressin 1–2 mg every 6 hours plus albumin or placebo plus albumin up to 14 days.ResultsThe pooled analysis comprised 308 patients (terlipressin: n = 153; placebo: n = 155). HRS reversal was significantly more frequent with terlipressin vs. placebo (27% vs. 14%; P = 0.004). Terlipressin was associated with a more significant improvement in renal function from baseline until end of treatment, with a mean between‐group difference in SCr concentration of −53.0 μmol/L (P < 0.0001). Lower SCr, lower mean arterial pressure and lower total bilirubin and absence of known precipitating factors for HRS were independent predictors of HRS reversal and longer survival in terlipressin‐treated patients.ConclusionsTerlipressin plus albumin resulted in a significantly higher rate of HRS reversal vs. albumin alone in patients with HRS‐1. Terlipressin treatment is associated with improved renal function. (ClinicalTrials.gov identifier: OT‐0401, NCT00089570; REVERSE, NCT01143246).
Polycystic ovary syndrome with hyperandrogenism as a risk factor for non‐obese non‐alcoholic fatty liver disease
Authors: Kim J. J. , Kim D. , Yim J. Y. , Kang J. H. , Han K. H. , Kim S. M. , Hwang K. R. , Ku S. Y. , Suh C. S. , Kim S. H. , Choi Y. M. 
Published: March 2017

SummaryBackgroundNon‐alcoholic fatty liver disease (NAFLD) is known to be associated with polycystic ovary syndrome (PCOS). However, most studies investigated the prevalence of NAFLD in obese PCOS patients.AimTo compare the prevalence of non‐obese NAFLD in women with or without PCOS, and to assess an independent association between PCOS and NAFLD in a non‐obese Asian cohort.MethodsThis was a case–control study using a prospective PCOS cohort. After subjects with other potential causes of chronic liver disease were excluded, 275 non‐obese women with PCOS and 892 non‐obese controls were enrolled. NAFLD was determined by hepatic ultrasonography. Main outcomes were the prevalence of NAFLD on hepatic ultrasonography between non‐obese women with or without PCOS, and an independent association between non‐obese NAFLD and PCOS.ResultsNon‐obese women with PCOS had a significantly higher prevalence of NAFLD than those without PCOS (5.5% vs. 2.8%, P = 0.027). PCOS was associated with non‐obese NAFLD (odds ratio: 2.62, 95% confidence intervals: 1.25–5.48) after adjustment for age and body mass index (BMI). In women with PCOS, the level of androgenicity represented by free testosterone or free androgen index was associated with NAFLD after adjustment for age, BMI, lipid profile, insulin resistance or glycaemic status.ConclusionsNon‐obese NAFLD is more prevalent in women with polycystic ovary syndrome than in those without. In non‐obese patients with polycystic ovary syndrome, hyperandrogenemia may be an independent risk factor for non‐obese NAFLD.
Biased agonism and allosteric modulation of G protein‐coupled receptor 183 – a 7TM receptor also known as Epstein–Barr virus‐induced gene 2
Authors: Daugvilaite Viktorija , Madsen Christian Medom , Lückmann Michael , Echeverria Clara Castello , Sailer Andreas Walter , Frimurer Thomas Michael , Rosenkilde Mette Marie , Benned‐Jensen Tau 
Published: March 2017

AbstractBackground and PurposeThe GPCR Epstein–Barr virus‐induced gene 2 (EBI2, also known as GPR183) is activated by oxysterols and plays a pivotal role in the regulation of B cell migration during immune responses. While the molecular basis of agonist binding has been addressed in several studies, the concept of biased agonism of the EBI2 receptor has not been explored.Experimental ApproachWe investigated the effects of the EBI2 endogenous agonist 7α,25‐dihydroxycholesterol (7α,25‐OHC) on G protein‐dependent and ‐independent pathways as well as sodium ion allosterism using site‐directed mutagenesis and functional studies. Moreover, we generated a homology model of the EBI2 receptor to investigate the structural basis of the allosteric modulation by sodium.Key ResultsResidue N114, located in the middle of transmembrane‐III at position III:11/3.35, was found to function as an efficacy switch. Thus, substituting N114 with an alanine (N114A) completely abolished heterotrimeric G protein subunit Gi α activation by 7α,25‐OHC even though the specific binding of [3H]‐7α,25‐OHC increased. In contrast, the N114A mutant was still able to recruit β‐arrestin and even had an enhanced potency (18.7‐fold) compared with EBI2 wild type. Sodium had a negative allosteric effect on oxysterol binding that was mediated via N114, verifying the key role of N114. This was further supported by molecular modelling of the ion binding site based on a EBI2 receptor homology model.Conclusions and ImplicationsCollectively, our data point to N114 as a key residue for EBI2 signalling controlling the balance between G protein‐dependent and ‐independent pathways and facilitating sodium binding.
National time trend changes in psychotropic medication of child and adolescent psychiatric inpatients across Finland
Authors: Kronström Kim , Kuosmanen Lauri , Ellilä Heikki , Kaljonen Anne , Sourander Andre 
Published: March 2017

BackgroundThere have been no comprehensive studies on trends in psychotropic medication use in child and adolescent inpatient settings. The aim of this nationwide study was to report changes in the psychotropic medication given to child and adolescent psychiatric inpatients across Finland and the factors associated with those changes.MethodsWe asked the psychiatrist responsible for each inpatient to complete a questionnaire that included questions about the pharmacological treatment and background information. The data were collected on all inpatients on one selected study day in 2000 and 2011. Changes in the use of regular psychotropic medication were studied by comparing the data on 504 patients in 2000 and 412 patients in 2011.ResultsThe study showed that there had been a significant increase in the use of psychotropic medication from 2000 to 2011. According to the multivariate analysis, the increase in psychotropic medication was associated with the study year (in 2000 39%, in 2011 58%), but could not be explained by changes in diagnostic profiles, age distribution, suicidality, violence or the Children′s Global Assessment Scale scores. The use of combined psychotropic medication increased from 9% in 2000 to 25% in 2011. The increase in the use of antipsychotics among child inpatients was particularly noteworthy, with an increase from 10% to 32%.ConclusionsThere is a need for evidence‐based studies to clarify recommendations for indications and treatment practices when using psychotropic medication in children and adolescents. Cross‐cultural studies of the use of psychotropic medication are warranted.
Faster insulin action is associated with improved glycaemic outcomes during closed‐loop insulin delivery and sensor‐augmented pump therapy in adults with type 1 diabetes
Authors: Ruan Yue , Thabit Hood , Leelarathna Lalantha , Hartnell Sara , Wilinska Malgorzata E. , Tauschmann Martin , Dellweg Sibylle , Benesch Carsten , Mader Julia K. , Holzer Manuel , Kojzar Harald , Evans Mark L. , Pieber Thomas R. , Arnolds Sabine , Hovorka Roman ,   on behalf of AP@home consortium
Published: March 2017

We aimed to evaluate the relationship between insulin pharmacodynamics and glycaemic outcomes during closed‐loop insulin delivery and sensor‐augmented pump therapy. We retrospectively analysed data from a multicentre randomized control trial involving 32 adults with type 1 diabetes receiving day‐and‐night closed‐loop insulin delivery and sensor‐augmented pump therapy over 12 weeks. We estimated time‐to‐peak insulin action (t
max,

IA
) and insulin sensitivity (
S

I
) during both interventions, and correlated these with demographic factors and glycaemic outcomes. During both interventions, t
max,

IA
was positively correlated with pre‐ and post‐intervention HbA1c (r = 0.50‐0.52,
P
< .01) and mean glucose (r = 0.45‐0.62,
P
< .05), and inversely correlated with time sensor glucose, which was in target range 3.9 to 10 mmol/L (r = −0.64 to −0.47,
P
< .05). Increased body mass index was associated with higher t
max,

I
and lower
S

I
(both
P
< .05). During closed‐loop insulin delivery, t
max,

IA
was positively correlated with glucose variability (
P
< .05). Faster insulin action is associated with improved glycaemic control during closed‐loop insulin delivery and sensor‐augmented pump therapy.