bluuebunny/crossref_metadata_2025_split huggingface dataset:
A proteomic atlas of glypican‐3 interacting partners: Identification of alpha‐fetoprotein and other extracellular proteins as potential immunotherapy targets in liver cancer
Authors: Zhang Yi‐Fan , Lin Shaoli , Xiao Zhen , Ho Mitchell 
Published: October 2024

AbstractAntibody and cell‐based therapeutics targeting cell surface receptors have emerged as a major class of immune therapeutics for treating cancer. However, the number of cell surface targets for cancer immunotherapy remains limited. Glypican‐3 (GPC3) is a cell surface proteoglycan and an oncofetal antigen. In this study, we report a large‐scale tumor‐associated GPC3 co‐immunoprecipitation‐proteomic study using liver cancer xenograft tumors in mice. We identified 153 GPC3‐associated proteins through mass spectrometry. To identify potential drug targets, we categorized GPC3‐associated proteins based on their subcellular locations using UniProt annotations, with a focus on extracellular proteins. Additionally, we annotated differentially expressed proteins in hepatocellular carcinoma versus nontumor liver samples based on the literature, analyzed expression levels in tumor versus normal tissues using TCGA and GTEx databases via GEPIA, and identified prognostic liver cancer markers according to GEPIA. Among GPC3‐associated proteins, immunoglobulin superfamily member 1, alpha‐fetoprotein (AFP), FAT atypical cadherin 1, formin 1, and guanylate cyclase 2 C, were identified as potential therapeutic targets. Furthermore, we validated the direct protein interaction between GPC3 and AFP through immunoprecipitation with purified proteins and through co‐localization imaging using immunofluorescence microscopy. This study provides large proteomic datasets related to GPC3‐associated proteins, enhancing our understanding of glypican biology in cancer cells and offering a new approach to identifying immunotherapy targets.
Evaluation of Voltage Effect on FE‐DBD Plasma for Skin Treatment: Biometrics Analysis and Hyperspectral Investigation
Authors: Charipoor Parisa , Nilforoushzadeh Mohammad Ali , Ostovarpour Farzaneh , Amirkhani Mohammad Amir , Ghasemi Erfan , Nouri Maryam , Eskandari Najmeh , Dilmaghanian Aydin , Shokri Babak , Khani Mohammadreza 
Published: October 2024

ABSTRACTIn this research, animal samples were subjected to skin rejuvenation using the floating electrode dielectric barrier discharge plasma device. Plasma processing was performed on the dorsal area of the rat's neck, covering a surface area of 18 cm2. Biometric assessments, encompassing measurements of skin surface evaporation, moisture content, melanin and erythema levels, as well as skin firmness and elasticity, were conducted before treatment initiation, immediately posttreatment, at the 4th and the 10th week during the follow‐up period. Physical examinations were employed to investigate and record the active species generated by plasma as well as the temperature of the skin surface. The skin ultrasound device was utilized to assess the density and thickness of both the epidermis and dermis.
Condition assessment and predictive maintenance for contact probe using health index and encoder‐decoder LSTM model
Authors: Luk Shun‐Sun , Jin Yanwen , Zhang Xiaoge , Ng Vincent To‐Yee , Huang Jingyuan , Wong Chak‐Nam 
Published: October 2024

AbstractContact probe is broadly used for the continuous monitoring of microelectronic components in manufacturing industries. False rejection of fine product due to defective contact probe significantly reduces the yield in production. Traditionally, defect detection for contact probes heavily depends on a valid range manually defined by engineers over the measured value of certain parameters. However, the subjective range defined according to engineer experience is prone to trigger a high rate of false alarms due to the inherent noise in the measured parameters. To address this issue, we construct a health index (HI) with the contact resistance‐directly‐related features to help monitor and assess the condition of contact probe. Based on the established HI, we develop Long Short‐Term Memory (LSTM) encoder‐decoder machine learning model to assess the condition of contact probe by forecasting the HI value in the future. Encoders from LSTM and convolutional neural network (CNN) are selected as the encoder‐decoder architecture for the sequence‐to‐sequence prediction due to their advantage in extracting the correlation of features at different scales. An explainable Artificial Intelligence (XAI) technique named Local interpretable model‐agnostic explanations (LIME) is used to quantify the contribution of each feature to the model prediction. The encoder from CNN is found to outperform the LSTM encoder in extracting the inter‐feature correlation. Finally, the predicted HI is used to signal the alarm for the maintenance action of contact probe when its value is below a predefined threshold. Comparison between the action alarm triggered by the developed HI and the actual maintenance records suggests that the proposed approach achieves at least 75% accuracy for the triggered alarm in the next 15 mins.
Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues
Authors: Hashimoto Daiki , Fujimoto Kota , Nakata Masanori , Suzuki Takuya , Kumegawa Shinji , Ueda Yuko , Suzuki Kentaro , Asamura Shinichi , Yamada Gen 
Published: October 2024

AbstractBackgroundRecent progress in molecular and signal analyses revealed essential functions of cellular signals including androgen and related growth factors such as Wnt regulators for external genitalia (ExG) development and its pathogenesis. Accumulated data showed their fundamental functions also for erectile tissue (corporal body) development and its abnormalities. The current review focuses on such signals from developmental and functional viewpoints.MethodsExperimental strategies including histological and molecular signal analyses with conditional mutant mice for androgen and Wnt signals have been extensively utilized.Main findingsEssential roles of androgen for the development of male‐type ExG and urethral formation are shown. Wnt signals are associated with androgen for male‐type ExG organogenesis. Androgen plays essential roles in the development of erectile tissue, the corporal body and it also regulates the duration time of erection. Wnt and other signals are essential for the regulation of mesenchymal cells of erectile tissue as shown by its conditional mutant mouse analyses. Stress signals, continuous erection, and the potential of lymphatic characteristics of the erectile vessels with sinusoids are also shown.ConclusionReiterated involvement of androgen, Wnt, and other regulatory factors is stated for the development and pathogenesis of ExG and erectile tissues.
Catalysts for Liquid Organic Hydrogen Carriers (LOHCs): Efficient Storage and Transport for Renewable Energy
Authors: Alghamdi Huda S. , Ali Ahsan , Ajeebi Afnan M. , Jedidi Abdesslem , Sanhoob Mohammed , Aktary Mahbuba , Shabi A. H. , Usman Mohammad , Alghamdi Wasan , Alzahrani Shahad , Abdul Aziz Md. , Shaikh M. Nasiruzzaman 
Published: October 2024

AbstractRestructuring the current energy industry towards sustainability requires transitioning from carbon based to renewable energy sources, reducing CO2 emissions. Hydrogen, is considered a significant clean energy carrier. However, it faces challenges in transportation and storage due to its high reactivity, flammability, and low density under ambient conditions. Liquid organic hydrogen carriers offer a solution for storing hydrogen because they allow for the economical and practical storage of organic compounds in regular vessels through hydrogenation and dehydrogenation. This review evaluates several hydrogen technologies aimed at addressing the challenges associated with hydrogen transportation and its economic viablity. The discussion delves into exploring the catalysts and their activity in the context of catalysts′ development. This review highlights the pivotal role of various catalyst materials in enhancing the hydrogenation and dehydrogenation activities of multiple LOHC systems, including benzene/cyclohexane, toluene/methylcyclohexane (MCH), N‐ethylcarbazole (NEC)/dodecahydro‐N‐ethylcarbazole (H12‐NEC), and dibenzyltoluene (DBT)/perhydrodibenzyltoluene (H18‐DBT). By exploring the catalytic properties of noble metals, transition metals, and multimetallic catalysts, the review provides valuable insights into their design and optimization. Also, the discussion revolved around the implementation of a hydrogen economy on a global scale, with a particular focus on the plans pertaining to Saudi Arabia and the GCC (Gulf Cooperation Council) countries. The review lays out the challenges this technology will face, including the need to increase its H2 capacity, reduce energy consumption by providing solutions, and guarantee the thermal stability of the materials.
Not all that glitters is gold: Financial access, microfinance, and female unemployment in sub‐Saharan Africa
Authors: Asongu Simplice A. , Zogo Therese E. , Mete Mariette C. N. , Mensah Barbara D. 
Published: October 2024

AbstractThe present study assesses the relevance of microfinance institutions (MFIs) in the effect of financial access on gender economic inclusion in 44 countries in sub‐Saharan Africa (SSA) for the period 2004–2018. The adopted empirical strategy is interactive quantile regressions that are tailored to account for both simultaneity and unobserved heterogeneity. Two MFI dynamics are employed: MFIs per 1,000 km2 and MFIs per 100,000 adults. Financial access is measured in terms of female bank account ownership while gender inclusion is measured in terms of reducing female unemployment. We find that MFIs per 1,000 km2 must reach thresholds of between 2.328 and 2.490 at the 90th quantile of the female unemployment distribution in order for female bank account ownership to reduce female unemployment. The partial validity of the tested hypothesis is clarified and we note a few policy implications.
Teaching Architecture in the Age of Fragility
Authors: Frattari Camillo 
Published: October 2024

AbstractThe origin of academic architectural education can be found in the inauguration of the Académie d'Architecture in 1671 in France based on the idea of knowledge as the transmission of a ‘style’. This idea continues to characterize contemporary architectural education but in a different way, through the pursuit of a personal aesthetic expression or in the satisfaction of real estate and construction market requirements as a cynic acceptance of reality. To conceive architectural education only as serving the market is to lose the meaning of architecture itself as a way to design, and improve, humanity. The contemporary age is characterized by the notion of fragility that represents the many uncertainties of our time related to different issues involved in politics, economy, energy, ecology, and demography. In the field of architecture and urban design, the main causes of fragility come from the phenomena of planetary urbanization and climate change that are visible in disaster, migration, periphery, inequality, diversity, and planetary crisis. While the ‘Academié’ model of education is founded on the knowledge of historical buildings in their aesthetical prerogatives, an architectural education focused on the contemporary issues of fragility needs to be based on the knowledge of projects that faced these challenges, to define a conceptual framework of a new agenda with new theories, technics, and references. Teaching architecture in the age of fragility means promoting the critical role of architects inside, and for, human society through projects of adaptation, hospitality, community, process, coexistence, and imaginary.
Risk, Trust and Big Beautiful Mistakes*: Keys to Innovation in Architectural Education
Authors: Gullberg Johanna S. , Rødne Gro 
Published: October 2024

AbstractBy presenting examples from Making is Thinking and other educational initiatives in the architecture programme at the Norwegian University of Science and Technology, NTNU, this paper points to why risk-taking is especially needed in architectural education today, as global crises demand new and critical ways of working with architecture. From a Scandinavian horizon, the paper problematizes the paradox that educational systems instead of promoting education as the uncertain and troublesome business it is, tend to please students in their longing for predictability. The paper describes risky learning spaces where learners start by doing, preferably in teams and off campus, thereby counteracting predictability and opening up for unexpected mishaps to occur – mishaps with innovative potential. The paper shows that such risky learning spaces introduce collective, emotional and embodied dimensions in architectural education. Moreover, the paper contributes with experience-based knowledge regarding how trust – a precondition for risk-taking and a notion underexplored in research on higher education – may be established in educational settings. Building on the idea of a fruitful tension between risk and trust in educational spaces, the paper ends with a list of gutsy proposals for a pedagogy of mistakes. *“Big beautiful mistakes” is an expression used with inspiration from architect and educator Sami Rintala.
Stumbling as a Praxis of Design Practice. A Pedagogical Experiment in “Theory and Criticism of Architectural Action”
Authors: Quaglio Caterina , Bruno Edoardo 
Published: October 2024

AbstractThe Thesis Seminar “Theory and Critique of Architectural Action” is a multidisciplinary educational experience designed to explore the methodological aspects associated with the development of a research project in architectural design, with a focus on Master’s Degree Graduation. The Seminar identifies six key methodological issues in research related to project practices and approaches them from a multidisciplinary perspective, subjecting each component to critical examination. Through lectures and Seminar meetings, each discipline challenges these issues based on its scientific status, providing specialized disciplinary insights. In doing so, the Seminar equips students with the necessary theoretical and practical tools to test the application of a robust methodological structure to address various challenges arising from the real world in their research activities. The structure of the Seminar is not intended to establish a specific sequence among the research activities object of inquiry, nor does it seek to offer exhaustive solutions to every issue raised. Instead, the Seminar’s aim is to provide students with critical and methodological instruments within a collegial space for open discussion and debate. The pedagogical objective is to enable students to critically evaluate and systematize interdisciplinary knowledge and skills acquired during their previous academic journey, allowing them to position original research programs within the broader framework of design practice.
Seeds of Architecture: Ways of Teaching
Authors: Barosio Michela 
Published: October 2024

AbstractWithin the general frame of the conference enquiring about the plurality of architecture as a discipline, the two sessions dedicated to the ways of teaching specifically addressed the different teaching approaches questioning two of the six dichotomies characterizing the contemporary debate on architectural education. The first tension explored is the supposed opposition between architecture considered as a discipline, with its specific field of knowledge and epistemology, and, on the other hand, architecture is regarded as a method, a mindset, a modus operandi that can be applied to other fields than the built environment. The second dichotomy concerns the origin of architectural education which can be grounded on the study and imitation of the Masters of Architecture, as it was when architecture was taught in the frame of the École des Beaux-arts, or can be grounded in training the student to face specific topics or burning issues of the architectural discipline.
Mountains in Motion, Visions in Nutshells. The Alpine Way for Common Living
Authors: Tognon Alisia 
Published: October 2024

AbstractArchitectural research is defined as community practice and for communities. Architecture has always been constituted as an action of territorial settlement and domestication for the community liveability of places.This article, referring to the concepts of resilience and transformability of mountain systems, proposes to reflect on how rural mountain areas have always been able to adapt to changes thanks to the ability of communities to conceive common and shared design directions.The paper reflects on the conceptualization of commons and how they can be a model for resilient development in socially inclusive contexts. For this reason, an extensive review of historical palimpsests was conducted to understand how to start from the roots of the operating models.The article includes a field approach in Trentino’s valleys. The results are exploratory, as the process cannot be concluded and requires a long time for validation. From it, some working hypotheses are derived to be explored in further studies, such as reintroducing the commons into projects and societies in transformation.Architectural research in these contexts contributes to orienting knowledge through fundamental collaboration with other disciplines, which is helpful in defining regenerative processes consistent with specific environmental contexts.
Research on Environmental Perception and Preferences of Traditional Villages from the Perspective of Local Gaze: A Chinese Case Study
Authors: Xintong Wei , Haoming Zhou 
Published: October 2024

AbstractThe advent of mass tourism has endowed traditional villages with multiple identities as heritage sites, communities, and tourist attractions. As hosts, local villagers have begun to introspect and reevaluate the village environment that was once a part of their everyday landscape, giving rise to new spatial perceptions. As the primary stakeholders in village communities, indigenous inhabitants’ perceptions, preferences, and identifications with village spaces hold significant significance in preserving rural characteristics and sustaining village vitality. Using Hongkeng Village in southwest Fujian Province, China, as a case study, this study investigated local villagers’ perception of traditional village daily life space and activity paths from three dimensions: cultural cognition, emotional preference, and behavioral activities through observation, questionnaire surveys, and cognitive maps. The results show that villagers generally have high cognitive and low emotional perceptions of the exhibition space and the former staging space; they have high emotional perceptions of the neighborhood interaction space and the collective memory place; the activity path spreads from home to the surrounding area, and there are gender differences in the scope of activities. The study suggests that the development of the tourism industry has often overlooked historical context and the spirit of places. It emphasizes the need to rekindle the identity of “home” within the Tulou clusters of Hongkeng Village while maintaining a balanced distribution of public facilities and enriching residents’ leisure lives. This study is expected to provide insights for improving the living environment of tourism-oriented villages in China.
A New Form of Practice: La Rivoluzione delle Seppie
Authors: Adamo Rita Elvira 
Published: October 2024

AbstractThe paper describes the work of La Rivoluzione delle Seppie in Belmonte Calabro, where they have regenerated places and promoted new forms of community and social cohesion. The tested and implemented strategies aim to make these so-called marginal areas competitive and attractive within local and territorial systems and globally. The experimental nature of this practice is characterized by a methodology for designing and constructing placed-based interventions tailored to the territories and carried out through the involvement and protagonism of academics, students, institutions and local communities. A methodology that enhances the local skills implemented by knowledge of global stakeholders and it uses critical issues as opportunities to generate elements of innovation necessary to qualify the relaunch and the development of the area concerned. The action of La Rivoluzione delle Seppie started in Belmonte Calabro. The group acted as an agent of change and, above all, as a facilitator between the old and the new inhabitants. Not only Belmonte, but also BelMondo!
Architectural Thresholds: Critical Theory as soglia in Teaching Architecture and Urban Design
Authors: Boano Camillo 
Published: October 2024

AbstractIn Architecture and urban design education, critique it is hard to find anymore: it does seem lost in the call for a renewed disciplinary autonomy, localised territorial interests and the sole artistic and sovereign agency of the maestro: it seems hidden in the sustainability solutionism or reduced to margins, the sole negative with its arrogant tone, stripped from the forms of seminars and discussions and forced to be ancillary to design studios extremisms. The same happen to any form of critical theory, being marxist, relegated to its obsolescence, feminist labelled as activist and anti disciplinar or decolonial, still misjudged as infused in the call of social justice and exoticism. Starting from these assumptions and grounding the reflections in the pedagogical experiences of the author, the paper ask how is then possible to reconfigure critique in the present within a planetary catastrophe in which design is always/already implicated and entangled? What visions of critique are required to intervene into the tangle of ecological, economic, cultural, and sociopolitical conditions of today? What form this could take in architectural and urban design education? Mobilising a Foucault definition of critique as gesture that arrest, disorganise, denaturalise and dehegemonise and expanding it with a partial reading of abolitionist literature.
Weak and strong solutions to nonlinear SPDEs with unbounded noise
Authors: Goodair Daniel 
Published: October 2024

AbstractWe introduce an extended variational framework for nonlinear SPDEs with unbounded noise, defining three different solution types of increasing strength along with criteria to establish their existence. The three notions can be understood as probabilistically and analytically weak, probabilistically strong and analytically weak, as well as probabilistically and analytically strong. Our framework facilitates several well-posedness results for the Navier–Stokes Equation with transport noise, equipped with the no-slip and Navier boundary conditions.
Birkhoff Conjecture for Nearly Centrally Symmetric Domains
Authors: Kaloshin V. , Koudjinan C. E. , Zhang Ke 
Published: October 2024

AbstractIn this paper we prove a perturbative version of a remarkable Bialy–Mironov (Ann. Math. 196(1):389–413, 2022) result. They prove non perturbative Birkhoff conjecture for centrally-symmetric convex domains, namely, a centrally-symmetric convex domain with integrable billiard is ellipse. We combine techniques from Bialy–Mironov (Ann. Math. 196(1):389–413, 2022) with a local result by Kaloshin–Sorrentino (Ann. Math. 188(1):315–380, 2018) and show that a domain close enough to a centrally symmetric one with integrable billiard is ellipse. To combine these results we derive a slight extension of Bialy–Mironov (Ann. Math. 196(1):389–413, 2022) by proving that a notion of rational integrability is equivalent to the C0-integrability condition used in their paper.