bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of Anti-Type II Collagen Antibodies in Patients With Chronic Gouty Arthritis
Authors: Kim Hyun Ah , Seo Young-Il , Lee Jisoo , Jung Young Ok 
Published: September 2016

Objective
We hypothesized that chronic gouty arthritis patients would develop an immune response to type II collagen that would be revealed by the presence of anti-type II collagen (CII) antibodies in serum, which may in turn be involved in progression to non-remitting arthritis.

Methods
Chronic gouty arthritis was defined as crystal-confirmed gout in patients with no pain-free intercritical period, with or without the presence of tophi, who did not have clinical features of other forms of chronic arthritis. Age-matched gout patients suffering acute gouty attacks who had definite intercritical periods were selected as a control group. Four RA patients who had active disease were enrolled as a positive control group. Anti-CII antibodies were quantified in patient sera via ELISA using a human IgG anti-CII antibody assay kit. Correlations between anti-CII levels and clinical parameters were sought.

Results
Fifteen chronic gouty arthritis patients were identified. The anti-CII level was significantly higher among subjects with chronic gout compared to controls, but did not significantly differ in control gout patients during acute attacks and in the intercritical periods. Five patients with chronic gouty arthritis had anti-CII antibody levels higher than 200 AU/mL, whereas only one control gout patient exhibited this feature. Two of four patients with active RA had anti-CII antibody levels higher than 200 U/mL.
Patients with tophi had significantly higher anti-CII levels than those without, whereas patients showing radiographic erosion tended to have higher anti-CII levels than those without.

Conclusion
Patients with chronic gouty arthritis had significantly higher levels of anti-CII antibodies than control gout patients. Such antibody production would be triggered by initiation of cartilage damage but may also play a role in perpetuation of inflammation.
A critical review of the use and performance of different function types for modeling temperature-dependent development of arthropod larvae
Authors: Quinn Brady K. 
Published: September 2016

ABSTRACTTemperature-dependent development influences production rates of arthropods, including crustaceans important to fisheries and agricultural pests. Numerous candidate equation types (development functions) exist to describe the effect of temperature on development time, yet most studies use only a single type of equation and there is no consensus as to which, if any model predicts development rates better than the others, nor what the consequences of selecting a potentially incorrect model equation are on predicted development times. In this study, a literature search was performed of studies fitting development functions to development of arthropod larvae (99 species). The published data of most (79) of these species were then fit with 33 commonly-used development functions. Overall performance of each function type and consequences of using a function other than the best one to model data were assessed. Performance was also related to taxonomy and the range of temperatures examined. The majority (91.1 %) of studies were found to not use the best function out of those tested. Using the incorrect model lead to significantly less accurate (e.g., mean difference ± SE 85.9 ± 27.4 %, range: −1.7 to 1725.5 %) predictions of development times than the best function. Overall, more complex functions performed poorly relative to simpler ones. However, performance of some complex functions improved when wide temperature ranges were tested, which tended to be confined to studies of insects or arachnids compared with those of crustaceans. Results indicate the biological significance of choosing the best-fitting model to describe temperature-dependent development time data.HighlightsTemperature-dependent development functions of arthropod larvae were reviewed79 published datasets were re-tested and fit with 33 different function types91.1 % of published studies did not fit their data with the best function of those testedPerformance differed among functions and was related to taxon and temperature range testedFunction type impacted predicted development times, so using the best function matters
Pre-metazoan origin of animal miRNAs
Authors: Bråte Jon , Neumann Ralf S. , Fromm Bastian , Haraldsen Arthur A. B. , Grini Paul E. , Shalchian-Tabrizi Kamran 
Published: September 2016

AbstractmicroRNAs (miRNAs) are integrated parts of the developmental toolkit in animals. The evolutionary history and origins of animal miRNAs is however unclear, and it is not known when they evolved and on how many occasions. We have therefore investigated the presence of miRNAs and the necessary miRNA biogenesis machinery in a large group of unicellular relatives of animals, Ichthyosporea. By small RNA sequencing we find evidence for at least four genes in the genusSphaeroformathat satisfy the criteria for the annotation of animal miRNA genes. Three of these miRNAs are conserved and expressed across sphaeroformid species. Furthermore, we identify homologues of the animal miRNA biogenesis genes across a wide range of ichthyosporeans, includingDroshaandPashawhich make up the animal specific Microprocessor complex. Taken together we report the first evidence forbona fidemiRNA genes and the presence of the miRNA-processing pathway in unicellular Choanozoa, implying that the origin of animal miRNAs and the Microprocessor complex predates multicellular animals.
DynOmics to identify delays and co-expression patterns across time course experiments
Authors: Straube Jasmin , Huang Bevan Emma , Lê Cao Kim-Anh 
Published: September 2016

ABSTRACTDynamic changes in biological systems can be captured by measuring molecular expression from different levels (e.g., genes and proteins) across time. Integration of such data aims to identify molecules that show similar expression changes over time; such molecules may be co-regulated and thus involved in similar biological processes. Combining data sources presents a systematic approach to study molecular behaviour. It can compensate for missing data in one source, and can reduce false positives when multiple sources highlight the same pathways. However, integrative approaches must accommodate the challenges inherent in ‘omics’ data, including high-dimensionality, noise, and timing differences in expression. As current methods for identification of co-expression cannot cope with this level of complexity, we developed a novel algorithm called DynOmics. DynOmics is based on the fast Fourier transform, from which the difference in expression initiation between trajectories can be estimated. This delay can then be used to realign the trajectories and identify those which show a high degree of correlation. Through extensive simulations, we demonstrate that DynOmics is efficient and accurate compared to existing approaches. We consider two case studies highlighting its application, identifying regulatory relationships across ‘omics’ data within an organism and for comparative gene expression analysis across organisms.
The RNA-binding protein RBP10 controls a regulatory cascade that defines bloodstream-form trypanosome identity
Authors: Mugo Elisha , Clayton Christine 
Published: September 2016

AbstractGene expression control in the pathogenTrypanosoma bruceirelies almost exclusively on post-transcriptional mechanisms, so RNA binding proteins must assume the burden that is usually borne by transcription factors.T. bruceimultiply in the blood of mammals as bloodstream forms, and in the midgut of Tsetse flies as procyclic forms. We show here that a single RNA-binding protein, RBP10, defines the bloodstream-form trypanosome differentiation state. Depletion of RBP10 from bloodstream-form trypanosomes gives cells that can grow only as procyclic forms; conversely, expression of RBP10 in procyclic forms converts them to bloodstream forms. RBP10 binds to procyclic-specific mRNAs containing an UAUUUUUU motif, targeting them for translation repression and destruction. Products of RBP10 target mRNAs include not only the major procyclic surface protein and enzymes of energy metabolism, but also protein kinases and stage-specific RNA-binding proteins: consequently, alterations in RBP10 trigger a regulatory cascade.
A comprehensive evaluation of multiband-accelerated sequences and their effects on statistical outcome measures in fMRI
Authors: Demetriou Lysia , Kowalczyk Oliwia S , Tyson Gabriella , Bello Thomas , Newbould Rexford D , Wall Matthew B 
Published: September 2016

AbstractAccelerated functional Magnetic Resonance Imaging (fMRI) with ‘multiband’ sequences is now relatively widespread. These sequences can be used to dramatically reduce the repetition time (TR) and produce a time-series sampled at a higher temporal resolution. We tested the effects of higher temporal resolutions for fMRI on statistical outcome measures in a comprehensive manner on two different MRI scanner platforms. Experiment 1 tested a range of acceleration factors (1-6) against a standard EPI sequence on a single composite task that maps a number of basic sensory, motor, and cognitive networks. Experiment 2 compared the standard sequence with acceleration factors of 2 and 3 on both resting-state and two task paradigms (an N-back task, and faces/places task), with a number of different analysis approaches. Results from experiment 1 showed modest but relatively inconsistent effects of the higher sampling rate on statistical outcome measures. Experiment 2 showed strong benefits of the multiband sequences on results derived from resting-state data, but more varied effects on results from the task paradigms. Notably, the multiband sequences were superior when Multi-Voxel Pattern Analysis was used to interrogate the faces/places data, but showed less benefit in conventional General Linear Model analyses of the same data. In general, ROI-derived measures of statistical effects benefitted relatively little from higher sampling resolution, with decrements even seen in one task (N-back). Across both experiments, results from the two scanner platforms were broadly comparable. The statistical benefits of high temporal resolution fMRI with multiband sequences may therefore depend on a number of factors, including the nature of the investigation (resting-state vs. task-based), the experimental design, the particular statistical outcome measure, and the type of analysis used. Higher sampling rates in fMRI are not a panacea, and it is recommended that researchers use multiband acquisition sequences conservatively.
Critiquing the marginalised place of research on women within international business
Authors: Michailova Snejina , Hutchings Kate 
Published: September 2016

PurposeThis paper aims to provide a critical perspective of how the theme of women, and more broadly gender, have been treated in extant international business (IB) literature. It also suggests meaningful and promising avenues in this research space.Design/methodology/approachThis paper is not intended to provide a comprehensive literature review; rather, it offers a critical and reflective view on the development of the IB stream of literature in which discussion of women has been largely marginalised.FindingsWhile women and gender have been topics of considerable discussion across a range of disciplines in the social sciences, they have received limited examination in the IB literature despite this discipline being most suitable for such, given its socio-cultural analyses across international borders and organisations.Research limitations/implicationsSeveral themes are suggested as fertile future research avenues. These themes identify gaps in existing knowledge but, more importantly, also problematize prevailing views that IB scholars tend to hold about women and gender. The future research themes suggest that the very context of IB signifies the need for systematic gender analysis which might advance current understanding of women specifically and gender, more broadly, in the IB field.Originality/valueThis paper makes a salient and timely contribution to the IB field in providing an original, erstwhile unexamined critique of the marginal reflection on women and gender within extant IB research.
Propensity score analysis: an alternative statistical approach for HRD researchers
Authors: Keiffer Greggory L. , Lane Forrest C. 
Published: September 2016

Purpose
This paper aims to introduce matching in propensity score analysis (PSA) as an alternative statistical approach for researchers looking to make causal inferences using intact groups.

Design/methodology/approach
An illustrative example demonstrated the varying results of analysis of variance, analysis of covariance and PSA on a heuristic data set. The three approaches were compared by results and violations of statistical assumptions.

Findings
Through the illustrative example, it is demonstrated how different statistical approaches can produce varied results. Only PSA mitigated pre-existing group differences without violating the assumption of independence.

Originality/value
This paper attempts to answer calls in the literature for more robust statistical methodologies to better inform human resource development practice and theory.
Contending claims to causality: a critical review of mediation research in HRD
Authors: Ghosh Rajashi , Jacobson Seth 
Published: September 2016

Purpose
The purpose of this paper is to conduct a critical review of the mediation studies published in the field of Human Resource Development (HRD) to discern if the study designs, the nature of data collection and the choice of statistical methods justify the causal claims made in those studies.

Design/methodology/approach
This paper conducts a critical review of published refereed articles that examined mediation in Human Resource Development Quarterly, Human Resource Development International, Advances in Developing Human Resources and European Journal of Training and Development. Mediation studies published in these journals from 2000 to 2015 were identified and coded. The four journals sampled were chosen to provide breadth of coverage of the different types of empirical studies published in the field of HRD.

Findings
The review findings imply that HRD scholars are not employing experimental or longitudinal designs in their studies when randomized experiments and longitudinal studies with at least three waves of data collection are regarded as the golden standards of causal research. Further, the findings indicate that sophisticated statistical modeling approaches like structural equation modeling are widely used to examine mediation in cross-sectional studies and most importantly, a large number of such studies do not acknowledge that cross-sectional data does not allow definite causal claims.

Research limitations/implications
Although the findings urge us to rethink the inferences of mediation effects reported over the past 15 years in the field of HRD, this study also serves as a guide in thinking about framing and testing causal mediation models in future HRD research and even argues for a paradigm shift from a positivist orientation to critical and postmodern perspectives that can accommodate mixed methods designs for mediation research in HRD.

Originality/value
This paper presents a critical review of the trends in examining mediation models in the HRD discipline, suggests best practices for researchers examining the causal process of mediation and directs readers to recent methodological articles that have discussed causal issues in mediation studies.
Regression discontinuity design: a guide for strengthening causal inference in HRD
Authors: Chambers Silvana 
Published: September 2016

Purpose
Regression discontinuity (RD) design is a sophisticated quasi-experimental approach used for inferring causal relationships and estimating treatment effects. This paper aims to educate human resource development (HRD) researchers and practitioners on the implementation of RD design as an ethical alternative for making causal claims about training interventions.

Design/methodology/approach
To demonstrate the key features of RD designs, a simulated data set was generated from actual pre-test and post-test diversity training scores of 276 participants from three organizations in the USA. Parametric and non-parametric analyses were conducted, and graphical presentations were produced.

Findings
This study found that RD design can be used for evaluating training interventions. The results of the simulated data set yielded statistically significant results for the treatment effects, showing a positive causal effect of the training intervention. The analyses found support for the use of RD models with retrospective training intervention data, eliminating ethical concerns from random group assignment. The results of the non-parametric model provided evidence of the plausibility of finding the right balance between precision of estimates and generalizable results, making it an alternative to experimental designs.

Practical implications
This study contributes to the HRD field by explicating the implementation of a sophisticated, statistical tool to strengthen causal claims, contributing to an evidence-based HRD approach to practice and providing the R syntax for replicating the analyses contained herein.

Originality/value
Despite the growing number of scholarly articles being published in HRD journals, very few have used experimental or quasi-experimental design approaches. Therefore, a very limited amount of research has been devoted to uncovering causal relationships.
Employability and performance: a comparison of baby boomers and veterans in The Netherlands
Authors: Hennekam Sophie 
Published: September 2016

PurposeThe purpose of this paper is to examine how the baby boomer generation and the veteran generation in the Netherlands perceive their own employability and how this is related to their self-reported job performance.Design/methodology/approachIn total, 973 workers in employment aged 45 and over filled out a survey measuring self-perceived employability and self-reported job performance. Data were analyzed by the use oft-tests and multiple regression.FindingsBased on the human capital theory, it was found that self-perceived employability was positively related to self-reported job performance. However, in contradiction with our expectations, the veterans perceived their internal and external employability as more positive than the baby boomers.Originality/valueThis study distinguishes between two generations that are part of the group “older workers”. Moreover, we show that a positive relationship exists between one’s perception of one’s own employability and their self-reported performance.
Australian universities and the commemoration of the First World War
Authors: Darian-Smith Kate , Waghorne James 
Published: September 2016

Purpose
The purpose of this paper is to examine how Australian universities commemorated the First World War, with a focus on the University of Melbourne as an institution with a particularly rich history of wartime participation and of diverse forms of memorialisation.

Design/methodology/approach
A case study approach is taken, with an overview of the range of war memorials at the University of Melbourne. These include memorials which acknowledged the wartime role of individuals or groups associated with the University, and took the form of architectural features, and named scholarships or academic positions. Three cross-campus war memorials are examined in depth.

Findings
This paper demonstrates that there was a range of war memorials at Australian universities, indicating the range of views about the First World War, and its legacies, within university communities of students, graduates and staff.

Originality/value
University war commemoration in Australia has not been well documented. This study examines the way in which the particular character of the community at the University of Melbourne was to influence the forms of First World War commemoration.
Studying the influence of strategic human resource competencies on the adoption of green human resource management practices
Authors: Yong Jing Yi , Mohd-Yusoff Yusliza 
Published: September 2016

Purpose
The purpose of this paper is to examine the influence of strategic human resource (HR) competencies of HR professionals on the adoption of green human resource management (HRM) practices.

Design/methodology/approach
A quantitative research approach using survey was employed to get insights from 87 HR professionals from Malaysian manufacturing and service companies.

Findings
The findings revealed that only strategic positioner and change champion are significantly related to green HRM practices. Specifically, strategic positioner associates positively with all green HRM practices including green analysis and description of job position, green recruitment, green selection, green training, green performance assessment, and green rewards. Additionally, change champion is positively related to green analysis and description of job position, and green rewards.

Originality/value
The extant literature suggests HR professionals’ competencies can play a key role in adopting green HRM. However, examining the relationship between strategic HR competencies and each of the green HRM practices has been limited. As such, this study is timely to address the existing gap in the literature and provide fresh insights and implications in this regard.
Honour based violence as a global public health problem: a critical review of literature
Authors: Bhanbhro Sadiq , Cronin de Chavez Anna , Lusambili Adelaide 
Published: September 2016

Purpose“Honour”-based violence (HBV), a form of gender-based violence (GBV), has received increasing interest from media, human rights organisations, academics and the public. A significant increase in the occurrence and reporting of HBV in many parts of the world and its detrimental impact on the health and well-being of women, girls, communities and wider society; marks it as a major public health concern. However, awareness and recognition of HBV in the field of public health is low in many countries and there is little known about its nature, roots and distribution. The paper aims to discuss these issues.Design/methodology/approachThe literature was searched using the Scopus database and a series of search terms related to HBV, GBV and health and well-being.FindingsDefinition of HBV and its forms is varied across cultures. There is a lack of consensus on how HBV can be identified over other forms of violence and no explicit theoretical perspectives have been sufficiently developed to deepen the understanding of HBV. Although the findings from the review suggest that HBV forms and patterns may be regionally distinct, causes emanate from gender-based and socio-economic inequalities.Research limitations/implicationsThis review has limitations in that it included only English and Spanish language papers and those accessed through Scopus; it therefore may have excluded papers from other languages, countries and databases. Another major weakness in this review was a lack of papers specifically dedicated to HBV. Despite these weaknesses the paper is an attempt to raise awareness and recognition of HBV in public health research, policy and practice domain.Originality/valueThe findings from the review highlight the complexity of tackling HBV in a globalised world. They also provide insights on how a public health model can be used to analyse both the causes and prevention of HBV. Further, a non-culturalised, unprejudiced and inclusive definition is required to flag-up and record HBV cases.