bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paradoxical bleeding and thrombotic episodes of dysprothrombinaemia due to a homozygous Arg382His mutation
Authors: Ding Qiulan , Yang Likui , Zhao Xiaoqing , Wu Wenman , Wang Xuefeng , Rezaie Alireza R. 
Published: December 2016

SummaryWe have characterised the pathogenic basis of dysprothrombinaemia in a patient exhibiting paradoxical bleeding and thrombotic defects during pregnancy and postpartum. Genetic analysis revealed that the proband is homozygous for the prothrombin Arg382His mutation, possessing only ~1 % clotting activity. The proband experienced severe bleeding episodes during her pregnancy, which required treatment with prothrombin complex concentrates, and then pulmonary embolism and deep-vein thrombosis at 28 days postpartum, which required treatment with LMWH and fresh frozen plasma. Analysis of haemostatic parameters revealed that the subject had elevated FDP and DD and decreased fibrinogen levels, indicating the presence of hyperfibrinolysis. Thrombin generation and clotting assays with the proband’s plasma in the presence of soluble thrombomodulin and tissue-type plasminogen activator indicated a defect in activation of both protein C and thrombin activatable fibrinolysis inhibitor (TAFI). Unlike normal plasma, no TAFI activation could be detected in the patient’s plasma. The expression and characterisation of recombinant prothrombin Arg382His indicated that zymogen activation by prothrombinase was markedly impaired and the activation of protein C and TAFI by thrombin-Arg382His was impaired 600-fold and 2500-fold, respectively. The recombinant thrombin mutant exhibited impaired catalytic activity toward both fibrinogen and PAR1 as determined by clotting and signalling assays. However, the mutant activated factor XI normally in both the absence and presence of polyphosphates. Arg382 is a key residue on (pro)exosite-1 of prothrombin and kinetic analysis of substrate activation suggested that the poor zymogenic activity of the mutant is due to its inability to bind factor Va in the prothrombinase complex.Supplementary Material to this article is available online at www.thrombosis-online.com.
Positive Trend in the Antarctic Sea Ice Cover and Associated Changes in Surface Temperature
Authors: Comiso Josefino C. , Gersten Robert A. , Stock Larry V. , Turner John , Perez Gay J. , Cho Kohei 
Published: December 2016

Abstract
The Antarctic sea ice extent has been slowly increasing contrary to expected trends due to global warming and results from coupled climate models. After a record high extent in 2012 the extent was even higher in 2014 when the magnitude exceeded 20 × 106 km2 for the first time during the satellite era. The positive trend is confirmed with newly reprocessed sea ice data that addressed inconsistency issues in the time series. The variability in sea ice extent and ice area was studied alongside surface ice temperature for the 34-yr period starting in 1981, and the results of the analysis show a strong correlation of −0.94 during the growth season and −0.86 during the melt season. The correlation coefficients are even stronger with a one-month lag in surface temperature at −0.96 during the growth season and −0.98 during the melt season, suggesting that the trend in sea ice cover is strongly influenced by the trend in surface temperature. The correlation with atmospheric circulation as represented by the southern annular mode (SAM) index appears to be relatively weak. A case study comparing the record high in 2014 with a relatively low ice extent in 2015 also shows strong sensitivity to changes in surface temperature. The results suggest that the positive trend is a consequence of the spatial variability of global trends in surface temperature and that the ability of current climate models to forecast sea ice trend can be improved through better performance in reproducing observed surface temperatures in the Antarctic region.
Evaluation of Statistical Downscaling of North American Multimodel Ensemble Forecasts over the Western United States
Authors: Barbero Renaud , Abatzoglou John T. , Hegewisch Katherine C. 
Published: December 2016

AbstractThe skill of two statistical downscaled seasonal temperature and precipitation forecasts from the North American Multimodel Ensemble (NMME) was evaluated across the western United States at spatial scales relevant to local decision-making. Both statistical downscaling approaches, spatial disaggregation (SD) and bias correction spatial disaggregation (BCSD), exhibited similar correlative skill measures; however, the BCSD method showed superior tercile-based skill measures since it corrects for variance deflation in NMME ensemble averages. Geographic and seasonal variations in downscaled forecast skill revealed patterns across the complex topography of the western United States not evident using coarse-scale skill assessments, particularly in regions subject to inversions and variability in orographic precipitation ratios. Similarly, differences in the skill of cool-season temperature and precipitation forecasts issued when the fall El Niño–Southern Oscillation (ENSO) signal was strong versus ENSO-neutral years were evident across topographic gradients in the northwestern United States.
Experiencing and Responding to Everyday Weather in Darwin, Australia: The Important Role of Tolerance
Authors: de Vet Eliza 
Published: December 2016

Abstract
Climates are changing, yet the everyday implications for societies and cultures are unclear. Until recently, weather and climate (change) have been largely represented quantitatively and discussed at broad spatial and social scales. Qualitative weather research is helping to reconnect weather with its diverse local meanings and to explain how climate change may alter future representational and behavioral understands of weather (herein called “weather-relations”) in the hope of furthering climate change action. Responding to the need for greater research into weather-relations, particularly in industrialized urban areas, this paper examines the role of weather in everyday life in tropical Darwin, Australia. It identifies a willingness among participants to stay “weather-connected” despite challenging weather conditions and access to air conditioning. This willingness is driven by desires to remain acclimatized in order to enhance positive weather sensations, retain outdoor lifestyles, and reduce financial and environmental costs associated with resource-intensive technologies. In delving into weather adjustment strategies that facilitate weather-connectedness along with possible climate change implications, greater potential for weather-relations research is recognized. By drawing attention to weather experiences and understandings alongside resource efficient weather responses, this paper uncovered a substantial capacity among participants to respond sustainably to environmental change. These capacities are the outcome of adjustment practices relating to food, clothing, laundering, physical and outdoor activities, and domestic comfort and a previously unrecognized coping strategy—expressions of tolerance. Findings suggest that by recognizing and fostering existing adjustment capabilities of societies and cultures and the local values that afford their reproduction, communities would be better placed to adapt to future climate change.
SwitchFinder – a novel method and query facility for discovering dynamic gene expression patterns
Authors: Bulashevska Svetlana , Priest Colin , Speicher Daniel , Zimmermann Jörg , Westermann Frank , Cremers Armin B. 
Published: December 2016

AbstractBackgroundBiological systems and processes are highly dynamic. To gain insights into their functioning time-resolved measurements are necessary. Time-resolved gene expression data captures temporal behaviour of the genes genome-wide under various biological conditions: in response to stimuli, during cell cycle, differentiation or developmental programs. Dissecting dynamic gene expression patterns from this data may shed light on the functioning of the gene regulatory system. The present approach facilitates this discovery. The fundamental idea behind it is the following: there are change-points (switches) in the gene behaviour separating intervals of increasing and decreasing activity, whereas the intervals may have different durations. Elucidating the switch-points is important for the identification of biologically meanigfull features and patterns of the gene dynamics.ResultsWe developed a statistical method, called SwitchFinder, for the analysis of time-series data, in particular gene expression data, based on a change-point model. Fitting the model to the gene expression time-courses indicates switch-points between increasing and decreasing activities of each gene. Two types of the model - based on linear and on generalized logistic function - were used to capture the data between the switch-points. Model inference was facilitated with the Bayesian methodology using Markov chain Monte Carlo (MCMC) technique Gibbs sampling. Further on, we introduced features of the switch-points:growth,decay,spikeandcleft, which reflect important dynamic aspects. With this, the gene expression profiles are represented in a qualitative manner - as sets of the dynamic features at their onset-times. We developed a Web application of the approach, enabling to put queries to the gene expression time-courses and to deduce groups of genes with common dynamic patterns.SwitchFinder was applied to our original data - the gene expression time-series measured in neuroblastoma cell line upon treatment with all-transretinoic acid (ATRA). The analysis revealed eight patterns of the gene expression responses to ATRA, indicating the induction of the BMP, WNT, Notch, FGF and NTRK-receptor signaling pathways involved in cell differentiation, as well as the repression of the cell-cycle related genes.ConclusionsSwitchFinder is a novel approach to the analysis of biological time-series data, supporting inference and interactive exploration of its inherent dynamic patterns, hence facilitating biological discovery process. SwitchFinder is freely available at https://newbioinformatics.eu/switchfinder.
A retrospective analysis of personality disorder presentations in a Canadian university-affiliated hospital's emergency department
Authors: Penfold Sarah , Groll Dianne , Mauer-Vakil Dane , Pikard Jennifer , Yang Megan , Mazhar Mir Nadeem 
Published: December 2016

BackgroundIndividuals with personality disorders often have extensive involvement with healthcare services including frequent utilisation of emergency departments.AimsThe aim of this study was to identify factors associated with emergency department presentations by individuals with personality disorders.MethodA 12-month retrospective data analysis of all mental-health-related emergency department visits was performed. Age, gender, time and season of presentation, length of stay, mode of arrival and discharge arrangements for individuals with personality disorders were compared to individuals with other psychiatric diagnoses.ResultsThere were 336 visits by individuals with personality disorders and 5290 visits by individuals with other psychiatric diagnoses.Individuals with personality disorders were significantly more likely to be female, young adults, brought in by police, arrive in the evening, discharged home and have a longer median length of stay.ConclusionKnowing what factors are associated with emergency department presentations by individuals with personality disorders can help ensure that appropriately trained support staff are available.
A Randomized Controlled Trial of Music Use During Epidural Catheter Placement on Laboring Parturient Anxiety, Pain, and Satisfaction
Authors: Drzymalski Dan M. , Tsen Lawrence C. , Palanisamy Arvind , Zhou Jie , Huang Chuan-Chin , Kodali Bhavani S. 
Published: December 2016

BACKGROUND:
Although music is frequently used to promote a relaxing environment during labor and delivery, the effect of its use during the placement of neuraxial techniques is unknown. Our study sought to determine the effects of music use on laboring parturients during epidural catheter placement, with the hypothesis that music use would result in lower anxiety, lower pain, and greater patient satisfaction.

METHODS:
We conducted a prospective, randomized, controlled trial of laboring parturients undergoing epidural catheter placement with or without music. The music group listened to the patient’s preferred music on a Pandora® station broadcast through an external amplified speaker; the control group listened to no music. All women received a standardized epidural technique and local anesthetic dose. The primary outcomes were 3 measures of anxiety. Secondary outcomes included pain, patient satisfaction, hemodynamic parameters, obstetric parameters, neonatal outcomes, and anesthesia provider anxiety. Intention-to-treat analysis with Bonferroni correction was used for the primary outcomes. For secondary outcomes, a P value of <.001 was considered statistically significant.

RESULTS:
A total of 100 parturients were randomly assigned, with 99 included in the intention-to-treat analysis. Patient characteristics were similar in both groups; in the music group, the duration of music use was 31.1 ± 7.7 minutes (mean ± SD). The music group experienced higher anxiety as measured by Numeric Rating Scale scores immediately after epidural catheter placement (2.9 ± 3.3 vs 1.4 ± 1.7, mean difference 1.5 [95% confidence interval {CI} 0.2–2.7], P = .02), and as measured by fewer parturients being “very much relaxed” 1 hour after epidural catheter placement (51% vs 78%, odds ratio {OR} 0.3 [95% CI 0.1–0.9], P = .02). No differences in mean pain scores immediately after placement or patient satisfaction with the overall epidural placement experience were observed; however, the desire for music use with future epidural catheter placements was higher in the music group (84% vs 45%, OR 6.4 [95% CI 2.5–16.5], P < .0001). No differences in the difficulty with the epidural catheter placement or in the rate of cesarean delivery were observed.

CONCLUSIONS:
Music use during epidural catheter placement in laboring parturients is associated with higher postprocedure anxiety and no improvement in pain or satisfaction; however, a stronger desire for music with future epidural catheter placements was observed. Further investigation is needed to determine the effect of music use in parturients requesting and using epidural labor analgesia.
CRISIS: METAPHOR OR ESSENCE
Authors: Морозов Сергей , Morozov Sergey , Погодин Михаил , Pogodin Mikhail 
Published: December 2016

The purpose of this article is to establish the contextual environment of the concept of &#34;crisis&#34; in economic and socio-philosophical context.
To achieve objectives the methods are used to estimate economic models and theories on the basis of socio-philosophical approach.
As a result of the conclusions that are logically correct term &#34;crisis&#34; is only possible in local areas of knowledge, and a comprehensive interpretation of the crises is not productive. In the Russian context special direction of research crises dominates - in the framework of anti-crisis enterprise management.
Partial conclusions and recommendations of economic science in relation to crises do not meet the criteria reentrancy for different socio – economic conditions or types of objects. Diagnosis of the crisis confirms the ambiguity of findings regarding a crisis situation.
Relative to global economic theories given the conclusion that the challenges to anticipate and overcome the crisis cannot be solved within existing economic theory methods.

Development of mathematical apparatus, the introduction in the model of logical and qualitative indicators, the construction of behavioral models developed understanding of socio-economic systems and processes. But it is not allowed to create a universal economic theory of sustainable development and crises. The effectiveness of local approaches and global insolvency is discovered. Conclusion: in the framework of economic theory there cannot be formulated the minimum and sufficient set of consistent axioms required for solving problems of crisis.

Partial conclusion is made that the main issue of crisis management is the question of ownership of the company, as well as its obligations to external agents.

The scope of the results – socio-economic system, crisis management.
Safety and effectiveness of therapeutic magnetic resonance in diabetic foot ulcers: a prospective randomised controlled trial
Authors: Piaggesi A. , Sambataro M. , Nicoletti C , Goretti C. , Lacopi E. , Coppelli A. 
Published: December 2016

Objective: To test the efficacy and safety of therapeutic magnetic resonance (TMR) in the management of diabetic foot ulcers (DFU), the authors designed a prospective randomised controlled trial in three highly specialised diabetic foot clinics. Method: All the patients consecutively visited in a period of 18 months were screened according to the inclusion (presence of an ulcer >1 cm2 in the foot lasting at least 6 weeks; ABPI>0.6; consent to participate in the study) and exclusion (Charcot's foot; local or systemic infections; chronic renal failure; any wearable electrically-driven life-supporting device) criteria. Patients, who were treated according to international guideline protocols, were randomised into two groups: group A received for four weeks the sham application of TMR, while group B received the active TMR for the same period. People were followed-up to 10 weeks and healing rate (HR), healing time (HT), rate of granulation tissue on wound bed (% GT), reduction of the area of the lesion (∆AL) and a score (0–3) evaluating erythema, oedema, pain and tenderness, respectively, were measured. Adverse events (AE) were registered and monitored throughout the study. Results: No differences were observed in HR, HT and ∆AL between the two groups during follow-up, while % GT and the scores for erythema, oedema and pain at 10 weeks showed significant (p<0.05) improvements in group B compared with group A and versus baseline. When restricted to non-ischaemic patients (ABPI>0.8), ∆AL was significantly (p<0.05) more pronounced in group B than in group A. No difference in AE occurrence was observed between the two groups. Conclusion: Our study, despite not being able to demonstrate the effectiveness of TMR on healing rate at 10 weeks, with 4 weeks of active treatment in neuro-ischaemic DFUs, shows positive effects on clinical aspects of the DFU and is associated with a significant increase of GT in the wound bed. Declaration of interest: The study has been fully sponsored by Thereson S.p.A., manufacturer of TMR devices.
Aprendizaje Basado en Problemas mediante un modelo de Teleenseñanza
Authors: Martinez Garcia Miriam , Romero Faz David 
Published: December 2016

Durante los cursos académicos 2009-10, 2010-11, 2011-12, 2012-13 y 2013-14 se han aplicado técnicas de Aprendizaje Basado en Problemas junto con la utilización de un Modelo de Sistema de Teleenseñanza (e-learning) junto con un modelo de acción tutorial, con grupos de alumnos voluntarios de los últimos cursos de la Escuela Técnica Superior de Ingeniería Civil de la Universidad Politécnica de Madrid, logrando incrementar el tiempo de dedicación e implicación con las asignaturas. La experiencia se ha desarrollado con alumnos voluntarios matriculados en las asignaturas de Caminos (Grado), Caminos I (Antigua Ing. Téc.) y Caminos II (Antigua Ing. Téc.), ya que estas son asignaturas que históricamente han obtenido tasas de aprobados y eficiencia muy bajos, del entorno del 25%.El trabajo realizado ha consistido, en un primer lugar, en conocer las expectativas que los alumnos tienen sobre la acción tutorial, tanto al comienzo del curso como una vez finalizado este, y posteriormente trabajar con alumnos voluntarios aplicando el Aprendizaje Basado en Problemas (ABP) para la adquisición de conocimientos apoyándose en un sistema de acción tutorial basado en la tele-enseñanza.La utilización de estas técnicas de aprendizaje han hecho que los resultados obtenidos a lo largo de la investigación sean mucho más satisfactorias que las obtenidas sin la aplicación de estas técnicas, ya que ha dado lugar a un número de aprobados cercano al 100%, con mejores calificaciones, destacando la reducción que se ha producido en las tasas de abandono en las asignaturas estudiadas, llegando a obtener niveles despreciables.
Evaluation of pixel-wise geometric constraint-based phase-unwrapping method for low signal-to-noise-ratio (SNR) phase
Authors: An Yatong , Liu Ziping , Zhang Song 
Published: December 2016

Abstract
This paper evaluates the robustness of our recently proposed geometric constraint-based phase-unwrapping method to unwrap a low-signal-to-noise ratio (SNR) phase. Instead of capturing additional images for absolute phase unwrapping, the new phase-unwrapping algorithm uses geometric constraints of the digital fringe projection (DFP) system to create a virtual reference phase map to unwrap the phase pixel by pixel. Both simulation and experimental results demonstrate that this new phase-unwrapping method can even successfully unwrap low-SNR phase maps that bring difficulties for conventional multi-frequency phase-unwrapping methods.
Δμ-sets and ∇μ-sets in generalized topological spaces
Authors: Jeyanthi Pon , Nalayini Periadurai , Noiri Takashi 
Published: December 2016

Abstract
In this paper, we introduce and study some properties of the sets, namely

Δ
μ

{\Delta_{\mu}}

-sets,

∇
μ

{\nabla_{\mu}}

-sets and

Δ
μ
*

{\Delta_{\mu}^{*}}

-closed sets in a generalized topological space.
Assessing Reactive Strength Measures in Jumping and Hopping Using the Optojump™ System
Authors: Healy Robin , Kenny Ian C. , Harrison Andrew J. 
Published: December 2016

Abstract
The aim of this study was to assess the concurrent validity of the Optojump™ system (Microgate, Bolzano, Italy) versus a force platform in the estimation of temporal and reactive strength measures. In two separate investigations, twenty physically active males performed double-leg and single-leg drop jumps from a box height of 0.3 m and a 10 s vertical bilateral hopping test. Contact time, flight time and total time (the sum of contact and flight time) were concurrently assessed during single and double-leg drop jumps and during hopping. Jump height, the reactive strength index and the reactive strength ratio were also calculated from contact time and flight time. Despite intraclass correlation coefficients (ICCs) for all variables being close to 1 (ICC > 0.975), a significant overestimation was found in contact time (0.005 ± 0.002 s) and underestimations in flight time (0.005 ± 0.003 s), the reactive strength index (0.04 ± 0.02 m·s-1) and the reactive strength ratio (0.07 ± 0.04). Overestimations in contact time and underestimations in flight time were attributed to the physical design of the Optojump™ system as the transmitter and receiver units were positioned 0.003 m above the floor level. The Optojump™ demonstrated excellent overall temporal validity with no differences found between systems for total time. Coaches are advised to be consistent with the instrumentation used to assess athletes, however, in the case of comparison between reactive strength values collected with the Optojump™ and values collected with a force platform, regression equations are provided.