bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of leucocyte and platelet‐rich fibrin in socket management and ridge preservation: a split‐mouth, randomized, controlled clinical trial
Authors: Temmerman Andy , Vandessel Jeroen , Castro Ana , Jacobs Reinhilde , Teughels Wim , Pinto Nelson , Quirynen Marc 
Published: August 2016

AbstractAimTo investigate the influence of the use L‐PRF as a socket filling material and its ridge preservation properties.Materials and MethodsTwenty‐two patients in need of single bilateral and closely symmetrical tooth extractions in the maxilla or mandible were included in a split‐mouth RCT. Treatments were randomly assigned (L‐PRF socket filling versus natural healing). CBCT scans were obtained after tooth extraction and three months. Scans were evaluated by superimposition using the original DICOM data. Mean ridge width differences between timepoints were measured at three levels below the crest on both the buccal and lingual sides (crest −1 mm (primary outcome variable), −3 mm and −5 mm).ResultsMean vertical height changes at the buccal were −1.5 mm (±1.3) for control sites and 0.5 mm (±2.3) for test sites (p < 0.005). At the buccal side, control sites values were, respectively, −2.1 (±2.5), −0.3 mm (±0.3) (p < 0.005) and −0.1 mm (±0.0), and test sites values were, respectively, −0.6 mm (±2.2) (p < 0.005), −0.1 mm (±0.3) and 0.0 mm (±0.1). Significant differences (p < 0.005) were found for total width reduction between test (−22.84%) and control sites (−51.92%) at 1 mm below crest level. Significant differences were found for socket fill (visible mineralized bone) between test (94.7%) and control sites (63.3%).ConclusionThe use of L‐PRF as a socket filling material to achieve preservation of horizontal and vertical ridge dimension at three months after tooth extraction is beneficial.
Needs among persons with human immunodeficiency virus and intellectual and developmental disabilities in community mental health care: a cross‐sectional study
Authors: Durbin A. , Sirotich F. , Lunsky Y. , Roesslein K. , Durbin J. 
Published: August 2016

AbstractBackgroundThe experience of having human immunodeficiency virus (HIV) is often associated with co‐occurring mental health issues. Community mental health services are an important source of support for persons with HIV living in the community. Persons with intellectual disability (ID) are vulnerable to HIV and may have unique support needs beyond those without ID receiving community care. This study compared support needs of men with HIV in community mental health programmes, with and without ID.MethodsThe sample was composed of 138 HIV‐positive men with and without ID receiving mental health case management from one community organisation in Ontario, Canada, on 31 March 2013. Staff‐rated needs across 16 domains grouped into four clusters were measured using the Camberwell Assessment of Need: Basic needs (accommodation, food, public transportation, money and benefits); self‐care/functional needs (looking after the home, self‐care and daytime activities); health/safety needs (physical health, psychological distress, psychotic symptoms, safety to self and safety to others); and social needs (company, intimate relationships and sexual expression). Adjusted logistic regression models examined the association between ID and each need domain.ResultsOne‐quarter of the sample (n = 34/138, 24.6%) had co‐occurring ID. Those with ID were more likely to have needs in the basic cluster [odds ratios: food 4.05 (1.14, 14.44), P:0.031; benefits 2.58 (1.05, 6.32), P:0.038)] and self‐care/functional cluster [looking after the home (2.75 (1.17, 6.49), P:0.021); self‐care (2.72 (1.18, 6.27), P:0.019)], but were less likely to have need for sexual expression: 0.35 (0.14,0.90), P:0.030) (social cluster). There were no differences in the domains in the health/safety cluster.ConclusionDespite elevated cognitive needs in the basic and self‐care/functional clusters for the ID group, limited other differences suggest that with moderate additional targeting, community mental health programmes for persons with HIV may be appropriate for men with ID.
Homocysteine metabolism is associated with cerebrospinal fluid levels of soluble amyloid precursor protein and amyloid beta
Authors: Oikonomidi Aikaterini , Lewczuk Piotr , Kornhuber Johannes , Smulders Yvo , Linnebank Michael , Semmler Alexander , Popp Julius 
Published: August 2016

AbstractDisturbed homocysteine metabolism may contribute to amyloidogenesis by modulating the amyloid precursor protein (APP) production and processing. The objective of this study was to investigate the relationships between cerebral amyloid production and both blood and cerebrospinal fluid (CSF) markers of the homocysteine metabolism. We assessed CSF concentrations of soluble APPα, soluble APPβ, and amyloid β1‐42 (Aβ1‐42), as well as plasma levels of homocysteine (Hcys), total vitamin B12, and folate, and CSF concentrations of homocysteine (Hcys‐CSF), 5‐methyltetrahydrofolate (5‐MTHF), S‐adenosylmethionine (SAM), and S‐adenosylhomocysteine (SAH) in 59 subjects with normal cognition. Linear regression analyses were performed to assess associations between homocysteine metabolism parameters and amyloid production. The study was approved by the Ethical Committee of the University of Bonn. After controlling for age, gender, APOEe4 status, and albumin ratio (Qalb), higher Aβ1‐42 CSF levels were associated with high Hcys and low vitamin B12 plasma levels as well as with high Hcys, high SAH, and low 5‐MTHF CSF levels. Higher CSF concentrations of sAPPα and sAPPβ were associated with high SAH levels. The results suggest that disturbed homocysteine metabolism is related to increased CSF levels of sAPP forms and Aβ1‐42, and may contribute to the accumulation of amyloid pathology in the brain.
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Disturbed homocysteine metabolism may contribute to amyloidogenesis by modulating the amyloid precursor protein (APP) production and processing. We found associations between CSF levels of soluble APP forms and Aβ1‐42, and markers of the homocysteine metabolism in both plasma and CSF in adults with normal cognition. Disturbed homocysteine metabolism may represent a target for preventive and early disease‐modifying interventions in Alzheimer's disease.
Work engagement–team performance relationship: shared job crafting as a moderator
Authors: Mäkikangas Anne , Aunola Kaisa , Seppälä Piia , Hakanen Jari 
Published: August 2016

The aims of this study were twofold: first, to investigate whether both individual and team work engagement are associated with team members' perceived team performance, and, second, to explore whether shared job crafting within teams moderates the relationship between work engagement and team members' perceived team performance. Data were collected from 1,074 Finnish educational sector employees working in 102 teams. Multilevel analysis revealed that both individual and team work engagement were associated with high levels of perceived team performance. The association between work engagement (both individual and team) and perceived team performance, however, varied across teams. The variation in the individual work engagement–perceived team performance relation was explained by shared job crafting of resources (but not of challenging demands): The higher the level of increasing structural and social job resources in the team, the stronger the association between individuals' work engagement and perceived team performance in that team. To conclude, shared job crafting in a team promotes a team climate in which, by increasing individual work engagement, it is possible to enhance team performance.Practitioner points

Both individual and team work engagement contribute to a team's performance.

Engaged employees are able to boost team performance, especially in teams where job crafting is common.

Job crafting behaviour should be promoted at both the individual and team level in order to contribute to team performance.
Older Rural‐ and Urban‐Dwelling Appalachian Adults With Mild Cognitive Impairment
Authors: Mattos Meghan K. , Snitz Beth E. , Lingler Jennifer H. , Burke Lora E. , Novosel Lorraine M. , Sereika Susan M. 
Published: August 2016

AbstractPurposeMild cognitive impairment (MCI) is a well‐recognized risk state for Alzheimer's disease and other dementias. MCI is rapidly increasing among older adults in general and has not yet been examined in older adults within the Appalachian region. Our objective was to compare MCI symptom severity among older rural and urban Appalachian adults with MCI at an initial neuropsychological testing visit.MethodsA cross‐sectional, descriptive study of older Appalachian adults with MCI was conducted using data from the National Alzheimer's Coordinating Center Uniform Data Set. Symptom severity was conceptualized as neuropsychological composite scores across 4 cognitive domains and Clinical Dementia Rating‐Sum of Boxes (CDR‐SOB) score. For group comparisons, MANCOVA was used for cognitive domains and ANCOVA for CDR‐SOB.ResultsThe sample (N = 289) was about half male (54.3%), predominantly white (91.7%), and living with others (83.5%), with a mean (±SD) 74.6 ± 6.2 years of age and 15.4 ± 3.0 years of education. Rural and urban groups differed significantly in years since onset of cognitive symptoms (2.98 ± 1.91 in rural and 3.89 ± 2.70 in urban adults,t[260] = –2.23,P= .03), but they did not differ across sociodemographic features or comorbid conditions. Rural and urban participants were similar across the 4 cognitive domains and CDR‐SOB (P≥ .05).DiscussionNo differences were found between rural and urban Appalachian residents on MCI symptom severity. However, urban residents reported a longer time lapse from symptom identification to diagnosis than their rural counterparts. Future studies using more representative population samples of Appalachian and non‐Appalachian adults will provide an important next step to identifying disparate cognitive health outcomes in this traditionally underserved region.
Structure influence on mechanical and acoustic properties of freeze‐dried gels obtained with the use of hydrocolloids
Authors: Ciurzyńska Agnieszka , Marzec Agata , Mieszkowska Arleta , Lenart Andrzej 
Published: August 2016

AbstractThe influence of the structure formed by the type of hydrocolloids (low‐methoxyl pectin, the mixture of xanthan gum, and locust bean gum, and mixture of xanthan gum, and guar gum) and the aeration time (3, 5, 7, and 9 min) on textural properties of freeze‐dried gels were investigated. The hardest texture generating the strongest acoustic emission was obtained by freeze‐dried pectin gel, characterised by the lowest porosity and the largest pore diameter. Aeration time significantly affected mechanical and acoustic properties of the pectin gel lyophilisate. No effect of gel aeration time on tested characteristics of samples with mixture of hydrocolloids was observed. Strong positive correlations between acoustic energy as well as the maximum force and work and negative ones between porosity and pore diameter indicate that greater resilience and stronger acoustic emission of freeze‐dried gels was caused by the reduction of porosity and the increase in the pore size of the material.Practical applicationsThe research is expected to show the phenomenon of structure formation when preparing and freeze‐drying gels and explain the influence of the process parameters (time of aeration, the type of hydrocolloids) on the formation of the internal structure and physical properties of a dried product, especially mechanical and acoustic properties. This achievement will contribute to the development of the science of food and human nutrition, especially within the context of the popular research on aerated diet products. The expected result will be the ability to develop a new technology for producing food with a delicate texture, using the phenomenon of sublimation. As a result, designing changes in the structure of freeze‐dried fruit gels with a delicate structure will be possible due to the choice of ingredients and aeration parameters in order to develop innovative food characterised by favorable nutritional, health and functional properties, which will be attractive for the consumers.
The addition effect of Tunisian date seed fibers on the quality of chocolate spreads
Authors: Bouaziz Mohamed Ali , Abbes Fatma , Mokni Abir , Blecker Christophe , Attia Hamadi , Besbes Souhail 
Published: August 2016

AbstractNovel chocolate spreads were enriched by soluble and insoluble dietary fibers from Tunisian Deglet Nour date seeds at 1, 2, 3, 4, and 5% levels in the conventional chocolate spread. Defatted Deglet Nour date seeds, date seed soluble fiber concentrate (DSSFC) and date seed insoluble fiber concentrate (DSIFC) were characterized by high levels of dietary fibers (80–90%). Chocolate spread enriched with 5% of DSSFC presented the highest oil binding capacity (304.62%) compared to the control (102%). Whatever the DSIFC and DSSFC incorporation levels, no significant difference was recorded between the firmness, chewiness, and adhesiveness of prepared chocolate spreads compared to the control (p < .05). Sensory evaluation revealed that all prepared chocolate spreads enriched by DSIFC and DSSFC were accepted by panelists. These results indicated the value of date seeds as new source of dietary fibers to develop chocolate spread and could also improve health benefits and functional properties.Paractical applicationTunisia is considered to be one of the dates‐producing countries. The mean annual yield of date fruits is about 200,000 tons. From this, around 20,000 tons of date seeds could be collected. This by‐product of date processing industries could be regarded as an excellent source of dietary fiber with interesting technological functionality and many beneficial effects on human health. Then, date seeds could present a value addition by extraction and use of date seed fiber concentrate in chocolate spread formulation.
Fruits and vegetables are incorporated into home cuisine in different ways that are relevant to promoting increased consumption
Authors: Penny Mary E. , Meza Krysty S. , Creed‐Kanashiro Hilary M. , Marin R. Margot , Donovan Jason 
Published: August 2016

AbstractFruits and vegetables are essential for healthy life. We examined the fruits and vegetables consumption by 240 caregivers and their children aged 1–17 years in peri‐urban Lima, and the ways that they were incorporated into local cuisine. A randomized cross‐sectional household survey collected information on the weight of all foods eaten the previous day (24 h) including fruits and vegetables, their preparation and serving sizes. Fruit and vegetable consumption was low and very variable: fruit intake was mean 185.2 ± 171.5 g day−1, median 138 g day−1 for caregivers and 203.6 ± 190.6 g day−1 and 159 g day−1 for children, vegetable intake was mean 116.9 ± 94.0 g day−1 median 92 g day−1 for caregivers, mean 89.3 ± 84.7 g day−1 median 60 g day−1 for children. Only 23.8% of children and 26.2% of caregivers met the recommended ≥400 g of fruit or vegetable/day. Vegetables were mainly eaten either as ingredients of the main course recipe, eaten by about 80% of caregivers and children, or as salads eaten by 47% of caregivers and 42% of children. Fruits were most commonly eaten as whole fresh fruits eaten by 68% of caregivers and 75% of children. In multivariate analysis of the extent to which different presentations contributed to daily fruit and vegetable consumption, main courses contributed most to determining vegetable intake for caregivers, and for children, main course and salads had similar contributions. For fruit intake, the amount eaten as whole fruit determined total fruit and total fruit plus vegetable intake for both caregivers and children. Local cuisine should be considered in interventions to promote fruit and vegetable consumption. © 2016 John Wiley & Sons Ltd
In vitro effects of different sources of fibrinogen supplementation on clot initiation and stability in a model of dilutional coagulopathy
Authors: Schäfer N. , Driessen A. , Bauerfeind U. , Fröhlich M. , Ofir J. , Stürmer E. K. , Maegele M. 
Published: August 2016

SUMMARYObjectivesTo analyse which fibrinogen source may improve coagulation using an in vitro 33% dilutional coagulopathy model.BackgroundUncritical volume resuscitation in the context of trauma haemorrhage contributes to the iatrogenic arm of the acute trauma‐induced coagulopathy through dilution and depletion of coagulation factors, with fibrinogen reaching critical levels first.Materials and MethodsBy using an experimental model of 33% dilutional coagulopathy, we have analysed which fibrinogen source may exert superior effects on improving haemocoagulative capacities and correcting depleted fibrinogen levels. As fibrinogen sources, we supplemented (i) fresh frozen plasma (FFP), (ii) fibrinogen concentrate low‐dose (Fiblow) and (iii) fibrinogen concentrate high‐dose (Fibhigh), the latter both in the presence and absence of additional FXIII.ResultsThe dilution was associated with decreased haemoglobin and haematocrit levels. Fibrinogen supplementation with fibrinogen‐containing formulations led to increased fibrinogen levels (FFP: 172·2 ± 17·4 mg dL−1; Fiblow: 211·5 ± 20·61 mg dL−1; Fibhigh: 255·8 ± 21·4 mg dL−1) than in a diluted‐only sample (155·5 ± 19·7 mg dL−1). Extrinsically activated assay with tissue factor (EXTEM) clot formation times, α‐angles and maximum clot firmness significantly improved in the groups of Fiblow + FXIII (79 ± 12·2 s; 74·3 ± 2·4°; 62 ± 2·3 mm), Fibhigh (70·8 ± 10·6 s; 76·2 ± 2·7°; 64·3 ± 2·3 mm) and Fibhigh + FXIII (69·8 ± 11·5 s; 77·5 ± 2·7°; 64·33 ± 2·5 mm) compared with the dilution groups (104·2 ± 19 s; 69·7 ± 2·9°; 56·5 ± 3·1 mm). In contrast, rotational thromboelastometric trace (ROTEM) measures of samples supplemented with FFP largely remained unchanged.ConclusionFibrinogen concentrates corrected and improved haemodilution‐induced changes in blood clotting in vitro. High‐dose fibrinogen supplementation was associated with correction and improvement in clot dynamics and stability.
IL‐4 downregulates expression of the target receptor CD30 in neoplastic canine mast cells
Authors: Bauer K. , Hadzijusufovic E. , Cerny‐Reiterer S. , Hoermann G. , Reifinger M. , Pirker A. , Valent P. , Willmann M. 
Published: August 2016

AbstractCD30 is a novel therapeutic target in human mast cell (MC) neoplasms. In this ‘comparative oncology’ study, we examined CD30 expression and regulation in neoplastic canine MC using a panel of immunomodulatory cytokines [interleukin‐2 (IL‐2), IL‐4, IL‐5, IL‐6, IL‐13 and stem cell factor (SCF)] and the canine mastocytoma cell lines NI‐1 and C2. Of all cytokines tested IL‐4 was found to downregulate expression of CD30 in NI‐1 and C2 cells. We also found that the CD30‐targeting antibody‐conjugate brentuximab vedotin induces growth inhibition and apoptosis in both MC lines. Next, we asked whether IL‐4‐induced downregulation of CD30 interferes with brentuximab vedotin‐effects. Indeed, pre‐incubation of NI‐1 cells with IL‐4 decreased responsiveness towards brentuximab vedotin. To overcome IL‐4‐mediated resistance, we applied drug combinations and found that brentuximab vedotin synergizes with the Kit‐targeting drugs masitinib and PKC412 in inhibiting growth of NI‐1 and C2 cells. In summary, CD30 is a new marker and IL‐4‐regulated target in neoplastic canine MC.
Validation of the Accutrend Plus point‐of‐care triglyceride analyzer in horses, ponies, and donkeys
Authors: Pongratz Michaela C. , Junge Hannah K. , Riond Barbara , Schwarzwald Colin C. 
Published: August 2016

AbstractObjectiveTo assess the accuracy and reliability of a point‐of‐care (POC) triglyceride analyzer and to establish reference intervals for blood ([TRIG]POC/WB) and plasma triglyceride concentrations ([TRIG]POC/PL) in horses, ponies, and donkeys.DesignProspective study.SettingUniversity teaching hospital.Animals120 adult healthy equids (78 horses and ponies, 42 donkeys) and 79 equids suffering from hypertriglyceridemia (73 horses and ponies, 6 donkeys).InterventionsNone.Measurements and Main Results[TRIG]POC/WB and [TRIG]POC/PL were measured using a POC analyzer and plasma triglyceride concentrations were measured using a standard laboratory assay ([TRIG]LAB/PL). Reference intervals were determined. Test accuracy was assessed by Bland–Altman comparison of POC measurements with standard laboratory measurements and by evaluating linearity of dilutional series. Test reliability was assessed by repeated serial measurements.[TRIG]POC/WB and [TRIG]POC/PL were below the analytic range of the POC assay (<0.8 mmol/L [<70 mg/dL]) in healthy horses and ponies, whereas the reference intervals were 0.82–3.14 mmol/L (73–278 mg/dL) and 0.87–3.02 mmol/L (77–267 mg/dL), respectively, in donkeys. The POC analyzer systematically overestimated triglyceride concentrations when compared to a standard laboratory assay. The difference between [TRIG]POC/WB and [TRIG]POC/PL was small and clinically negligible. The coefficient of variation of repeated measures performed on the POC analyzer was below 10% for [TRIG]POC/WB and [TRIG]POC/PL, both in horses and donkeys and at all concentration ranges.ConclusionsThe POC analyzer allows accurate and reliable measurement of [TRIG]POC/WB and [TRIG]POC/PL in horses, ponies, and donkeys in clinical settings. Assay‐specific reference intervals should be determined for diagnosis and clinical monitoring of hypertriglyceridemia in equids.
The Elaboration Model in Adapted Activity Research: Increasing the Programmatic Value of Program Evaluations
Authors: Hunter I. Roy , Reynolds Ronald P. , Williams M. Laura 
Published: August 2016

The purpose of this article is to introduce practitioners involved in the provision of adapted activity service to the elaboration model of data analysis. The authors contend that the use of the elaboration model for the analysis of program evaluation data: (a) can be used by activity specialists who do not have extensive training in statistics, and (b) can increase the potential for the production of empirically based programmatic recommendations from such data.The example presented herein involves the secondary analysis of data collected during the evaluation of a child life activity program. The original study concluded that the children studied showed less regressive behavior on nights that the child life program was offered. The findings from the secondary analysis enabled the identification of children who were: (a) more likely to experience regressive behavior, and (b) more likely to be responsive to existing child life programs. It was concluded that the use of the elaboration model significantly increased the value of recommendations which were derived from the data.
Comparison of Isometric Portable Fixed Dynamometry to Isokinetic Dynamometry for Assessment of Hip Strength
Authors: Kollock Roger O. , Van Lunen Bonnie , Linza Jennifer L. , Onate James A. 
Published: August 2016

Context:Assessment of hip strength can be performed with either isokinetic or isometric testing procedures, but the degree of association between values derived from the alternative testing methods has not been previously documented.Objective:To investigate the relationship between isometric peak torque and isokinetic peak torque at 60°·s-1 for various hip motions.Participants:Eighteen physically active males (N = 9) and females (N = 9) participated (22 ± 3 years, 173.0 ± 10.5 cm, 73.8 ± 16.7 kg).Intervention(s):Three isokinetic repetitions at 60°·s-1 and three isometric contractions of 5 s each for the hip fexors (HFs), hip extensors (HEs), hip abductors (ABs), hip adductors (ADs), hip external rotators (ERs), and hip internal rotators (IRs).Outcome Measures:Pearson correlation coefficients and coefficients of determination were calculated for both absolute and allometric-scaled peak torque values.Results:Meaningful associations between isometric and isokinetic peak torque values were found for each hip motion. Allometric-scaled strength values demonstrated stronger correlations than absolute strength values.Conclusions:The results suggest that portable fixed isometric testing of hip strength is an alternative to isokinetic testing at 60°·s-1.