bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgery of patellar fractures using a medial parapatellar approach
Authors: Yoon Yong-Cheol , Sim Jae-Ang , Hong Jin-Hun 
Published: July 2017

Purpose: The general surgical approach for patellar fractures has a significant weakness, in that the articular facet is invisible because the fixation is performed using radiation amplifiers after exposing the fracture site through vertical or transverse dissection on the anterior patella. We report excellent outcomes in the surgical treatment of patellar fractures, using a medial parapatellar approach. Methods: This study evaluated 20 patients who underwent surgery between August 2008 and April 2014 to correct patellar fractures with comminution or with displacement of the articular facet of ≥2 mm and who had ≥1 year of follow-up. Surgery was performed using anatomical reduction with direct exposure of the articular facet of the patella via a medial parapatellar approach. Bone union, severity of displacement, range of motion (ROM) of the patella, and complications were evaluated after surgery, and patellar function was evaluated using the Lysholm knee score. Results: Bone union was achieved in all cases, and average displacement of the articular facet decreased from 3.2 mm (range: 1.2–7.3 mm) preoperatively to 0.2 mm (range: 0–0.5 mm) postoperatively. No particular postsurgical complication was observed. All cases had a normal ROM, and the average Lysholm score at final follow-up was 96.2 points. Conclusion: Anatomical fixation of the articular facet via a medial parapatellar approach appears to be suitable for patellar fractures, which are intra-articular.
STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production
Authors: Clemens Regina A. , Chong Joshua , Grimes Derayvia , Hu Yongmei , Lowell Clifford A. 
Published: July 2017

Key PointsSTIM1 and STIM2 cooperatively regulate neutrophil SOCE. The interaction of oxidative stress and calcium signaling pathways imparts a specific role for STIM2 in neutrophil cytokine synthesis.
Treated secondary acute myeloid leukemia: a distinct high-risk subset of AML with adverse prognosis
Authors: Boddu Prajwal , Kantarjian Hagop M. , Garcia-Manero Guillermo , Ravandi Farhad , Verstovsek Srdan , Jabbour Elias , Borthakur Gautam , Konopleva Marina , Bhalla Kapil N. , Daver Naval , DiNardo Courtney D. , Benton Christopher B. , Takahashi Koichi , Estrov Zeev , Pierce Sherry R. , Andreeff Michael , Cortes Jorge E. , Kadia Tapan M. 
Published: July 2017

Key Pointsts-AML (arising from treated antecedent hematological disorder) is less responsive to currently applied treatment strategies. Future trial designs should accommodate this entity as a distinct category, and patients would be best evaluated on investigational therapies.
Carbon Black Nanoparticles Inhibit Aromatase Expression and Estradiol Secretion in Human Granulosa Cells Through the ERK1/2 Pathway
Authors: Simon Violaine , Avet Charlotte , Grange-Messent Valérie , Wargnier Richard , Denoyelle Chantal , Pierre Alice , Dairou Julien , Dupret Jean-Marie , Cohen-Tannoudji Joëlle 
Published: July 2017

AbstractSecretion of 17-β-estradiol (E2) by human granulosa cells can be disrupted by various environmental toxicants. In the current study, we investigated whether carbon black nanoparticles (CB NPs) affect the steroidogenic activity of cultured human granulosa cells. The human granulosa cell line KGN and granulosa cells from patients undergoing in vitro fertilization were treated with increasing concentrations of CB NPs (1 to 100 µg/mL) together or not with follicle-stimulating hormone (FSH). We observed that CB NPs are internalized in KGN cells without affecting cell viability. CB NPs could be localized in the cytoplasm, within mitochondria and in association with the outer face of the endoplasmic reticulum membrane. In both cell types, CB NPs reduced in a dose-dependent manner the activity of aromatase enzyme, as reflected by a decrease in E2 secretion. A significant decrease was observed in response to CB NPs concentrations from 25 and 50 µg/mL in KGN cell line and primary cultures, respectively. Furthermore, CB NPs decreased aromatase protein levels in both cells and reduced aromatase transcript levels in KGN cells. CB NPs rapidly activated extracellular signal-regulated kinase 1 and 2 in KGN cells and pharmacological inhibition of this signaling pathway using PD 98059 significantly attenuated the inhibitory effects of CB NPs on CYP19A1 gene expression and aromatase activity. CB NPs also inhibited the stimulatory effect of FSH on aromatase expression and activity. Altogether, our study on cultured ovarian granulosa cells reveals that CB NPs decrease estrogens production and highlights possible detrimental effect of these common NPs on female reproductive health.
Place-based collaboration: Leadership for a changing world
Authors: Hambleton Robin 
Published: July 2017

Abstract
Placeless power, meaning the exercise of power by decision-makers who are unconcerned about the impact of their decisions on communities living in particular places, has grown significantly in the last thirty years. A consequence is that societies are becoming more unequal. Even in the wealthy global cities modern capitalism is increasing inequality at a formidable rate. In a new book the author provides an international, comparative analysis of the efforts being made by place-based leaders to create inclusive, sustainable cities. This article draws on the evidence presented in the book to suggest that place-based leaders can play a significant role in advancing social justice, promoting care for the environment and bolstering community empowerment. An opening section introduces the idea of place-based power, providing a context for the subsequent discussion. A second section sets out a new way of conceptualising the roles of place-based leaders in any given context, a framework described as the New Civic Leadership. This distinguishes five different realms of civic leadership. The third section provides an example of place-based leadership in action. It outlines the way local leadership has brought about a remarkable transformation of the central area of Melbourne, Australia. A final section presents a comparative discussion of three themes relating to place-based leadership and local collaboration: (i) the changing possibilities for place-based leadership in our rapidly globalising world, (ii) the need for outward-facing local government leadership given the changing nature of public policy challenges and (iii) the role of place-based leadership in bringing about radical public innovation.
Shared services – shared necessity: Austerity, reformed local government and reduced budgets1
Authors: Lloyd Greg 
Published: July 2017

Abstract
Shared services are now established as a core delivery model in local and regional governance arrangements. Shared services have emerged as a ‘common sense’ delivery vehicle with attendant efficiency and effectiveness gains. There is, however, a more complex intellectual provenance to a reliance on shared services. In essence, shared services are the logical outcome of the deliberate turn to neo-liberal thinking and the various iterations of the new public managerialism methodology which has progressively established itself in local and regional governance over the past thirty years or so. This paper explores the neo-liberal provenance of shared services and considers the consequential vulnerabilities to austerity, administrative reform and reduced public sector budgets. The central proposition of the paper is that while neo-liberal ideas have created the justification for shared services, this has embedded a set of systemic tensions in the delivery model.
Possible impacts of zoosporic parasites in diseases of commercially important marine mollusc species: part I. Perkinsozoa
Authors: Gleason Frank H. , Lilje Osu , Dang Cecile , Geraci-Yee Sabrina , Collier Jackie L. 
Published: July 2017

AbstractThe phylum Perkinsozoa includes well-known parasites of commercially important species of molluscs in aquaculture, such as
One-pot synthesis of annulated 1,8-naphthyridines
Authors: Bardasov Ivan N. , Alekseeva Anastasiya U. , Yaschenko Nataliya N. , Zhitar Svetlana V. , Lyshchikov Anatoliy N. 
Published: July 2017

Abstract
Annulated 1,8-naphthyridines were synthesized by one-pot reaction of aromatic aldehyde, malononitrile dimer and enehydrazinoketone.
Impact of spatial correlations on the surface estimation based on terrestrial laser scanning
Authors: Jurek Tobias , Kuhlmann Heiner , Holst Christoph 
Published: July 2017

Abstract
In terms of high precision requested deformation analyses, evaluating laser scan data requires the exact knowledge of the functional and stochastic model. If this is not given, a parameter estimation leads to insufficient results. Simulating a laser scanning scene provides the knowledge of the exact functional model of the surface. Thus, it is possible to investigate the impact of neglecting spatial correlations in the stochastic model. Here, this impact is quantified through statistical analysis.
The correlation function, the number of scanning points and the ratio of colored noise in the measurements determine the covariances in the simulated observations. It is shown that even for short correlation lengths of less than 10 cm and a low ratio of colored noise the global test as well as the parameter test are rejected. This indicates a bias and inconsistency in the parameter estimation. These results are transferable to similar tasks of laser scanner based surface approximation.
Segmentation of Brain Tumour Based on Clustering Technique: Performance Analysis
Authors: Agrawal Ritu , Sharma Manisha , Singh Bikesh Kumar 
Published: July 2017

AbstractManual detection and analysis of brain tumours is an exhaustive and time-consuming process. Further, it is subject to intra-observer and inter-observer variabilities. Automated brain tumour segmentation and analysis has thus gained much attention in recent years. However, the existing segmentation techniques do not meet the requirements of real-time use due to limitations posed by poor image quality and image complexity. This article proposes a hybrid approach for image segmentation by combining biorthogonal wavelet transform, skull stripping, fuzzy c-means threshold clustering, Canny edge detection, and morphological operations. Biorthogonal wavelet transform and skull stripping are essential pre-processing steps for analysis of brain images. Initially, biorthogonal wavelet transform is used to remove impulsive noise and skull stripping is employed to eliminate non-cerebral tissue regions from the acquired images, followed by segmentation using fuzzy c-means threshold clustering, Canny edge detection, and morphological processing. The performance of the proposed automated system is tested on standard datasets using performance measures such as Jaccard index, Dice similarity coefficient, execution time, and entropy. The proposed method achieves a Jaccard index and Dice similarity coefficient of 0.886 and 0.935, respectively, which indicate better overlap between the automated segmentation method and manual segmentation method performed by an expert radiologist. The average execution time and average entropy values obtained are 1.001 s and 0.202, respectively. The results obtained are discussed in view of some reported studies in terms of execution time and tumour area. Further work is needed to evaluate the proposed method in routine clinical practice and its effect on radiologists’ performances.
Radiochemical separation of 231Pa from siliceous cake prior to its determination by gamma ray spectrometry
Authors: Dalvi Aditi A. , Verma Rakesh 
Published: July 2017

Abstract
A simple and fast radiochemical method for the separation of protactinium (231Pa) from siliceous cake for its determination by gamma ray spectrometry is described. The method involves (a) a novel approach, the fusion of the siliceous cake with sodium peroxide, (b) the dissolution of the fused mass in nitric acid and (c) the co-precipitation of 231Pa with manganese dioxide formed in-situ by the addition of solid manganous sulfate and potassium permanganate to the solution. The fusion, effected in a single step, is simpler and highly effective in comparison to methods reported hitherto in literature. The radiochemical yield of 231Pa, determined using 311.9 keV gamma ray of 233Pa radiotracer is quantitative (~90%). The decontamination factors calculated using gamma ray spectrometry and energy dispersive X-ray fluorescence measurements show that the separation from the interfering radionuclides is high whereas separation from major and minor elements is good. Separation by ion-exchange method in hydrochloric acid, hydrofluoric acid and oxalic acid media have comparatively much lower yields. The concentration of 231Pa in the siliceous cake measured using interference-free 283.6 keV gamma ray was found to be (6.4±0.33) μg kg−1. The measured concentration of 231Pa was well above the limit of quantitation whereas the coefficient of variation was ~5%. The improvement in the limit of detection was due to the reduction in spectral background. Systematic evaluation of various uncertainty parameters showed that the major contributors to the combined uncertainty were efficiency of the high purity germanium detector and the counting statistics. The present sample decomposition and separation methods are robust, simple to perform and can be effectively used for the determination and hence source prospecting of protactinium.
On the concept of “sign” in the Hebrew Bible
Authors: Cantor Robert 
Published: July 2017

AbstractIn this paper, we examine the use of signs as instruments of thought in Semitic languages of the ancient Near East. We employ a Peircean concept of “sign” together with derived typologies based upon Categorical (after Peirce), temporal, and effectual relations between events, as conceived by the intended interpreter. Following a brief discussion of the “sign” concept as attested in extinct Semitic languages and in Biblical Hebrew, we perform a typological analysis of the use of signs in Biblical narrative. On this basis, we infer that some Biblical writers had a tacit awareness of a tripartite concept of “sign.” Furthermore, we demonstrate that different Biblical writers had different preferences for the use of signs: symbolic (abstract) signs were favored in the Torah and iconic (embodied) signs were favored by the Major Prophets.
Semiotics of textscapes and cultures
Authors: Stockinger Peter 
Published: July 2017

Abstract
This article presents a general outline of a theoretical and methodological framework for analyzing textscapes. Textscapes are signifying perceptual surfaces that form the interface with the meaning universe of a semiotic eco-system (of, for instance, the life-world of a social actor such as a person, a social group, a community, etc.). In this sense, textscape descriptions and comparisons are of central importance for a semiotics of cultures understood as a text- or discourse-based approach to the description of meaning systems that possess a constitutive and normative status for a semiotic eco-system. The description of such meaning configurations composing the doxa (visions, beliefs, values and norms, know-how, etc.) of a social actor has to rely on a structured approach for dealing adequately with textscapes as the principal data to be studied. Research tasks include the identification of relevant textscapes, the techniques for collecting and conserving them, the analysis of corpora of textscapes or the experimentation with textscapes. In order to illustrate our purpose, we will study two examples of textscapes in a broad sense, understood as signifying 3D-surfaces of the lifeworld of social actors: a typical European open market in Vienna and a middle-class European kitchen. A third example in Hong Kong studies a modern urban communicational textscape.
Bells and the Problem of Realism in Ravel’s Early Piano Music
Authors: Kieffer Alexandra 
Published: July 2017

Early in his career Maurice Ravel composed two pieces that take bells as their subject: “Entre Cloches” from Sites auriculaires, composed in 1897, and “La vallée des cloches,” the final movement of the 1905 work Miroirs. Although these pieces can be contextualized within a nineteenth-century lineage of French piano pieces that depict bell peals, they also set themselves apart by virtue of their heightened attention to the particularities of bell sonorities. Relying heavily on repetitive ostinato patterns, quartal harmonies, and intense dissonances, these pieces play in the nebulous space between transcription and composition.
Ravel’s experimentation with bell sonorities in his piano music can be understood in relation to a broader discourse surrounding the sound of bells in nineteenth-century France. A complex sonic object, bell resonance lent itself to different modes of listening: the harmoniousness of bell peals was a common refrain among romantic poets, Catholic clergy, and campanarian historians, but toward the end of the century it became increasingly common for physicists and popular-science publications to complain that bells were inherently discordant. In this context Ravel’s depictions of bells in “Entre cloches” and “La vallée des cloches” suggest a shift in the place of musical listening in nineteenth- and early twentieth-century cultures of aurality. Ravel’s musical listening entailed heightened attentiveness to the empirical qualities of non-musical sound; his pieces negotiate in new ways the boundary between musical composition and the protean sonic world outside of music. This reorientation of musical listening participates in a broader questioning by early twentieth-century modernists of the nature of music and its sonic material.
Constructing a Plan for Survival: Scientology as Cold War Psychology
Authors: Genter Robert 
Published: July 2017

AbstractDeveloped in the early 1950s by science fiction writer L. Ron Hubbard, Scientology was part of the larger postwar therapeutic culture that blended religion and psychology in a search for mental well-being. Unlike contemporaneous self-help gurus such as Norman Vincent Peale and Harry Overstreet, however, Hubbard painted a much bleaker portrait of modern life, one rife with forces of psychological and social control. Railing against communists, homosexuals, and feminists as well as against the decay of the family and the rise of the welfare state, Hubbard argued that Americans suffered from a waning sense of ontological security, living in a world that provided no support for self-identity. Hubbard refused, however, to shrink from such changes and lapse into nostalgia for a pre-modern, pre-technological world like Peale and others did; instead, he offered a way for individuals to appropriate the dynamism of modernity for themselves. As advanced industrialization erased distances between societies, revolutionized transportation, and computerized information systems, Hubbard reimagined the self as spiritual being possessing precisely those powers to manipulate time and space and to remake the world at large. Borrowing freely from Eastern religious ideas, cybernetic theory, and German idealism, Hubbard produced a philosophy that was staunchly libertarian, spiritual, and future-oriented, one that tapped into Cold War fears about psychological manipulation and waning personal autonomy and into dreams about the immanent power of human beings.
Childhood thyroid function, body composition and cardiovascular function
Authors: Barjaktarovic Mirjana , Korevaar Tim I M , Gaillard Romy , de Rijke Yolanda B , Visser Theo J , Jaddoe Vincent W V , Peeters Robin P 
Published: July 2017

ObjectiveThe cardiovascular system is a known target for thyroid hormone. Early-life cardiovascular alterations may lead to a higher risk of cardiovascular disease in adulthood. Little is known about the effects of thyroid hormone on cardiovascular function during childhood, including the role of body composition in this association.DesignPopulation-based prospective cohort of children (n = 4251, median age 6 years, 95% range: 5.7–8.0 years).MethodsThyroid-stimulating hormone (TSH) and free thyroxine (FT4) concentrations were measured to assess thyroid function. Left ventricular (LV) mass was assessed with echocardiography. Arterial stiffness was assessed with carotid-femoral pulse wave velocity (CFPWV). Systolic and diastolic blood pressure (BP) was measured. Body composition was assessed by dual-energy X-ray absorptiometry scan.ResultsFT4 was inversely associated with LV mass (P = 0.002), and with lean body mass (P < 0.0001). The association of FT4 with LV mass was partially mediated through variability in lean body mass (55% mediated effect). TSH was inversely associated with LV mass (P = 0.010), predominantly in boys. TSH was positively associated with systolic and diastolic BP (bothP < 0.001). FT4 was positively associated with CFPWV and diastolic BP (P < 0.0001,P = 0.008, respectively), and the latter association attenuated after adjustment for CFPWV.ConclusionsAt the age of 6 years, higher FT4 is associated with lower LV mass (partially through effects on lean body mass) and with higher arterial stiffness, which may lead to higher BP. Our data also suggest different mechanisms via which TSH and FT4 are associated with cardiovascular function during early childhood.
OPTIMALISASI PENGATURAN PERIKANAN LEMURU BERDASARKAN MEKANISME SUPPLY DAN DEMAND DI SELAT BALI
Authors: Sari Yesi Dewita , Koeshendrajana Sonny , Nababan Benny Osta 
Published: July 2017

Penelitian ini bertujuan untuk menentukan jumlah alat tangkap yang dioperasikan pada perikanan lemuru di Selat Bali, yang didasarkan pada mekanisme keseimbangan supply dan demand. Pendugaan parameter biologi dilakukan menggunakan model CYP, pendugaan kurva supply menggunakan model Clark dan pendugaan kurva demand menggunakan model Salvatore. Hasil analisis menunjukkan bahwa keseimbangan supply dan demand terjadi pada tingkat harga Rp 5.889 dengan jumlah produksi 10.149 ton per tahun. Sementara itu, berdasarkan hasil survei diperoleh data bahwa harga ikan lemuru berkisar antara Rp 1.500 – 2.000 dengan rata-rata jumlah produksi (tahun 1990-2007) 30.254 ton dengan rata-rata upaya penangkapan 16.934 trip per tahun. Pada kondisi Maximum Sustainable Yield diperoleh maksimum jumlah tangkapan adalah 21.418 ton per tahun dengan jumlah upaya penangkapan 8.023 trip per tahun. Jumlah upaya penangkapan ini setara dengan 81 unit purse seine dengan asumsi setiap unit purse seine memiliki 99 trip per tahun. Mengacu kepada jumlah produksi pada kondisi MSY, maka dengan jumlah produksi 10.149 ton per tahun pada kondisi keseimbangan supply dan demand, hanya 38 unit purse seine yang diperlukan di Selat Bali. Kebijakan pembatasan jumlah upaya penangkapan di lokasi tersebut diharapkan mampu memulihkan sumberdaya ikan lemuru, dan dalam jangka panjang eksploitasi dapat dilakukan secara optimal. Tittle: Optimalization of Governing ‘Lemuru’ Fishery Based on the Supply and Demand Mechanism in the Bali Strait.This research aimed to know amount of fishing effort for capturing lemuru in the Bali Strait based on supply demand equilibrium. Biology parameters were estimated by using CYP model, supply curve was estimated using Clark model and demand curve wos estimated using Salvatore model. Results show that supply demand equilibrium is reached at Rp 5,889 of price and 10,149 MT per year of harvest. Based on survey, price of lemuru was around Rp 1,500 – 2,000 with average of harvest (1990-2007) was 30,254 MT per year. At maximum sustainable yield (MSY), maximum harvest were 21,418 MT per year and fishing effort 8,023 trip per year. Fishing effort at MSY were 81 unit purse seine assuming that one unit purse seine operated 99 trips per year. Based on fishing effort and harvested fish at the MSY, with 10,149 ton per years at the equilibrium point of supply and demand of that particular fish, it required 38 units of purse seine in the Bali Strait. Limiting number of fishing effort in the Bali Strait is to be expected by which enabling to recover lemuru required in the long-run optimal exploitation rate of the lemuru.