bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eye‐sparing multidisciplinary approach for the management of lacrimal gland carcinoma
Authors: Esmaeli Bita , Yin Vivian T. , Hanna Ehab Y. , Kies Merrill S. , William William N. , Bell Diana , Frank Steven J. 
Published: March 2016

AbstractBackgroundWe analyzed local control and early ocular toxicity after eye‐sparing management of lacrimal gland carcinoma.MethodsFor consecutive patients with lacrimal gland carcinoma treated during 2007 to 2014, we reviewed tumor characteristics, treatment details, ocular toxic effects, and recurrence.ResultsTwenty patients, median age 55 years, were treated for lacrimal gland carcinoma during the study period; 11 had globe‐sparing surgery. Seven patients had adenoid cystic carcinoma, 2 had carcinoma ex pleomorphic adenoma, and 1 each had high‐grade and low‐grade adenocarcinoma. Ten patients underwent postoperative radiotherapy, median 60 Gy (range, 52–64 Gy), 6 with concurrent chemotherapy. At a median of 30 months after radiation, all patients had dry eye syndrome, and 1 patient had severe corneal and conjunctival damage leading to enucleation. All 11 patients were disease free at last contact, median follow‐up after surgery of 33 months.ConclusionAn eye‐sparing approach with surgery followed by adjuvant radiotherapy or chemoradiotherapy is feasible for selected patients with lacrimal gland carcinoma and is associated with a reasonable locoregional control and ocular toxicity profile. © 2016 Wiley Periodicals, Inc. Head Neck 38:1258–1262, 2016
Using the Verifiability lie Detection Approach in an Insurance Claim Setting
Authors: Vrij Aldert , Nahari Galit , Isitt Rebecca , Leal Sharon 
Published: March 2016

AbstractIn this experiment, we tested the verifiability approach in an insurance claim setting. Core of the verifiability approach is that truth tellers give more details that can be verified than liars. Fifty undergraduate students took part, who produced true and false insurance claim statements related to theft, loss, or damage. These statements were coded in terms of verifiability (the number of details that could be checked by an investigator) and witness factors (friends, police, other officials and CCTV cameras). Truth tellers provided more verifiable details than liars and liars provided more unverifiable details than truth tellers. In addition, truth tellers (versus liars) more frequently informed their friends about the incident or referred to CCTV footage of the incident. The potential and limitations of using the verifiability approach in insurance settings are discussed. Copyright © 2016 John Wiley & Sons, Ltd.
Mixed‐mode chromatography integrated with high‐performance liquid chromatography for protein analysis and separation: Using bovine serum albumin and lysozyme as the model target
Authors: Xia Hai‐Feng , Don Bin‐Bin , Zheng Meng‐Jie 
Published: March 2016

A type of mixed‐mode chromatography was integrated with high‐performance liquid chromatography for protein analysis and separation. The chromatographic behavior was tested using bovine serum albumin and lysozyme as model proteins. For the mixed‐mode column, the silica beads were activated with γ‐(2,3‐epoxypropoxy)‐propytrimethoxysilane and coupled with 4‐mercaptopyridine as the functional ligand. The effects of pH, salt, and the organic solvent conditions of the mobile phase on the retention behavior were studied, which provided valuable clues for separation strategy. When eluted with a suitable pH gradient, salt concentration gradient, and acetonitrile content gradient, the separation behavior of bovine serum albumin and lysozyme could be controlled by altering the conditions of the mobile phase. The results indicated this type of chromatography might be a useful method for protein analysis and separation.
Effects of Biochar and Marble mud on Mine Waste Properties to Reclaim Tailing Ponds
Authors: Muñoz Maria Angeles , Guzman Jose German , Zornoza Raul , Moreno Fabian , Faz Angel , Lal Rattan 
Published: March 2016

AbstractThe effects of biochar addition in improving soil physical properties are not clearly understood in mining tailings. The objective of this study was to determine the effects of three different types of biochars, in addition to marble mud (MM) and their mixtures, on the structural stability and water retention of mine wastes in Cartagena, Spain. Biochars were produced at 500 °C from pig manure (PM), cotton (Gossipium hirsutum L.) crop residues (CR) and municipal solid waste (MSW). Biochars were added to the mine waste (MW) along with MM and a control (no amendments added). These mixtures were incubated in cores for 90 days (25 °C). PM and CR mixed with MM decreased soil bulk density (from 0 · 98 g cm‐3 to 0 · 89 and 0 · 84 g cm−3, respectively). Amendments had no significant effect on total porosity whereas they increased gas diffusion by 100%, except for MSW. MM improved the plant available water from 0 · 59 to 2 · 56 cm as its combination with biochars, extremely relevant in water scarce climates. The micropores were likely replaced by mesopores when application of PM, CR, MM, and biochars + MM and they improved water retention. Total carbon (TC) and total nitrogen (TN) increased by using biochars and MM and no significant effects were assessed on aggregates. In general, MM mixed with PM and CR derived biochar improved the structural stability and exhibited a strong impact in reclaiming physical quality on mine tailings. Copyright © 2016 John Wiley & Sons, Ltd.
Retracted: Dental hard tissue ablation using mid‐infrared tunable nanosecond pulsed Cr:CdSe laser
Authors: Lin Taichen , Aoki Akira , Saito Norihito , Yumoto Masaki , Nakajima Sadahiro , Nagasaka Keigo , Ichinose Shizuko , Mizutani Koji , Wada Satoshi , Izumi Yuichi 
Published: March 2016

Background and ObjectiveMid‐infrared erbium: yttrium‐aluminum‐garnet (Er:YAG) and erbium, chromium: yttrium‐scandium‐gallium‐garnet (Er,Cr:YSGG) lasers (2.94‐ and 2.78‐μm, respectively) are utilized for effective dental hard tissue treatment because of their high absorption in water, hydroxide ion, or both. Recently, a mid‐infrared tunable, nanosecond pulsed, all‐solid‐state chromium‐doped: cadmium‐selenide (Cr:CdSe) laser system was developed, which enables laser oscillation in the broad spectral range around 2.9 μm. The purpose of this study was to evaluate the ablation of dental hard tissue by the nanosecond pulsed Cr:CdSe laser at a wavelength range of 2.76–3.00 μm.Study Design/Materials and MethodsEnamel, dentin, and cementum tissue were irradiated at a spot or line at a fluence of 0–11.20 J/cm2/pulse (energy output: 0–2.00 mJ/pulse) with a repetition rate of 10 Hz and beam diameter of ∼150 μm on the target (pulse width ∼250 ns). After irradiation, morphological changes, ablation threshold, depth, and efficiency, and thickness of the structurally and thermally affected layer of irradiated surfaces were analyzed using stereomicroscopy, scanning electron microscopy (SEM), and light microscopy of non‐decalcified histological sections.ResultsThe nanosecond pulsed irradiation without water spray effectively ablated dental hard tissue with no visible thermal damage such as carbonization. The SEM analysis revealed characteristic micro‐irregularities without major melting and cracks in the lased tissue. The ablation threshold of dentin was the lowest at 2.76 μm and the highest at 3.00 μm. The histological analysis revealed minimal thermal and structural changes ∼20 μm wide on the irradiated dentin surfaces with no significant differences between wavelengths. The efficiency of dentin ablation gradually increased from 3.00 to 2.76 μm, at which point the highest ablation efficiency was observed.ConclusionThe nanosecond pulsed Cr:CdSe laser demonstrated an effective ablation ability of hard dental tissues, which was remarkably wavelength‐dependent on dentin at the spectral range of 2.76–3.00 μm. These results demonstrate the potential feasibility of the use of pulsed Cr:CdSe laser as a novel laser system for dental treatment. Lasers Surg. Med. 48:965–977, 2016. © 2016 Wiley Periodicals, Inc.
Comparison of anti‐inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis
Authors: Kim Hyemee , Banerjee Nivedita , Ivanov Ivan , Pfent Catherine M. , Prudhomme Kalan R. , Bisson William H. , Dashwood Roderick H. , Talcott Stephen T. , Mertens‐Talcott Susanne U. 
Published: March 2016

ScopeTannin‐rich fruits have been evaluated as alternative prevention strategies for colorectal cancer based on their anti‐inflammatory properties. This study compared tannin‐rich preparations from mango (rich in gallotannins) and pomegranate (rich in ellagitannins) in the dextran sodium sulfate‐induced colitis model.Methods and resultsIn rats, mango and pomegranate beverages decreased intestinal inflammation and the levels of pro‐inflammatory cytokines in mucosa and serum. The mango beverage suppressed the ratio of phosphorylated/total protein expression of the IGF‐1R‐AKT/mTOR axis and downregulated mRNA expression of Igf1, Insr, and pik3cv. Pomegranate decreased p70S6K and RPS6, as well as Rps6ka2, Map2k2, and Mapk1 mRNA. In silico modeling indicated a high binding of docked of gallic acid to the catalytic domain of IGF‐1R, which may suppress the activity of the enzyme. Ellagic acid docked effectively into the catalytic domains of both IGF‐1R and EGFR. In vitro assays with lipopolysaccharide‐treated CCD‐18Co cells using polyphenolic extracts from each beverage, as well as pure compounds, corroborated the predictions made in silico.ConclusionMango polyphenols inhibited the IGF‐1R‐ AKT/mTOR axis, and pomegranate polyphenols downregulate the mTOR downstream pathway through reductions in ERK1/2. These results suggest that extracts rich in gallo‐ and ellagitannins act on different molecular targets in the protection against ulcerative colitis.
Vasoactive intestinal peptide promotes differentiation and clock gene expression in granulosa cells from prehierarchal follicles
Authors: Kim Dongwon , Johnson Alan L. 
Published: March 2016

SUMMARYVasoactive intestinal peptide (VIP) signaling via cyclic adenosine monophosphate (cAMP) is reported to stimulate steroidogenesis in ovarian granulosa cells from a variety of vertebrate species, including the domestic hen. Prior to follicle selection in the hen ovary (i.e., cyclic recruitment) follicle‐stimulating‐hormone (FSH)‐induced cAMP signaling is absent within the granulosa layer until immediately following follicle selection. As a consequence, granulosa cells remain in an undifferentiated state and are unable to initiate FSH‐induced steroidogenesis. VIP receptors (VPAC1 and VPAC2), like the FSH receptor, are G protein‐coupled receptors, so we predicted that VIP signaling in granulosa cells is also absent in follicles that have not yet been selected into the preovulatory hierarchy. Initial studies established that mRNA encoding VPAC1 and VPAC2 are expressed within the granulosa cells throughout follicle development. Nevertheless, undifferentiated granulosa cells from prehierarchal (6–8 mm) follicles do not accumulate cAMP in response to a 4‐hr incubation with chicken VIP; the capacity for such receptor signaling is attained only following selection within actively differentiating granulosa cells. VIP treatment did, however, increase expression of mRNA encoding the Gallus circadian clock protein, BMAL1—but only in granulosa cells collected from selected follicles. These findings provide evidence that, at follicle selection, the acquisition of VIP‐induced cAMP cell signaling helps initiate and promote the differentiation of of granulosa cells. Furthermore, we propose that VIP signaling may regulate BMAL1 expression and, thus, a daily rhythmicity within granulosa cells of preovulatory follicles. Mol. Reprod. Dev. 83: 455–463, 2016. © 2016 Wiley Periodicals, Inc.
Autonomic response during bladder hydrodistention reflects the severity of symptoms in patients with bladder pain syndrome/interstitial cystitis
Authors: Kim Sang Woon , Son Hee Seo , Troya Irela Soto , Kim Ji Yu , Kim Myoung Joo , Fraser Matthew O. , Kim Jang Hwan 
Published: March 2016

AimsTo evaluate the correlation between symptom severity of bladder pain syndrome/interstitial cystitis (BPS/IC) and autonomic nervous system activity, we examined autonomic responses during bladder hydrodistention.MethodsMedical records were collected from a prospective database for patients who underwent bladder hydrodistention with a fixed protocol from March 2012 to December 2013. A total of 40 patients (16 males, 24 females) were included for the analysis. Hydrodistention was performed under general anesthesia (31 patients), spinal anesthesia (six patients), and both types of anesthesia (three patients) at different times. Twenty‐five patients who underwent holmium laser enucleation of the prostate served as controls. Pulse rate (PR), systolic (SBP), and diastolic blood pressure (BP) were measured pre‐hydrodistention, during hydrodistention, and after drainage.ResultsThe spinal anesthesia and control groups exhibited little change in BP and PR during hydrodistention, while a significant increase was demonstrated in the general anesthesia group (e.g., ΔSBP 4.89 ± 4.80, 10.40 ± 19.03, and 56.26 ± 30.38 mm Hg, respectively, P < 0.001). Under general anesthesia, autonomic response during hydrodistention was more prominent in patients with preoperative visual analogue scale (VAS) pain score ≥7, Hunner's lesion, and glomerulation grade 4. Preoperative maximal cystometric capacity negatively correlated with changes in SBP during hydrodistention (R2 = 0.294, P = 0.009), while VAS score and interstitial cystitis problem index demonstrated a positive correlation with the changes (R2 = 0.208, P = 0.012; R2 = 0.173, P = 0.015).ConclusionsUnder general anesthesia, exaggerated autonomic responses to bladder hydrodistention were demonstrated in BPS/IC patients, which reflected the severity of symptoms. These results support the hypothesis of altered activity of autonomic system in BPS/IC. Neurourol. Urodynam. 36:677–682, 2017. © 2016 Wiley Periodicals, Inc.
Treatment of Cannabis Use Disorder: Current Science and Future Outlook
Authors: Sherman Brian J. , McRae‐Clark Aimee L. 
Published: March 2016

Cannabis is the most commonly used illicit substance in the United States. Rates of cannabis use and cannabis use disorder (CUD) have increased in the past decade, paralleling changes in the legal and political climate favoring legalization. Almost 20 million people 12 years or older report past‐month cannabis use, and 8 million report daily or near‐daily use. Concurrently, the perception that cannabis use poses a significant risk of negative consequences has decreased. Contrary to this perception, heavy cannabis use is associated with cognitive impairment, increased risk for psychotic disorders and other mental health problems, lower education attainment, and unemployment. Clinical trials of various treatments for CUD have likewise increased, focusing primarily on psychotherapy treatments, specifically motivational enhancement therapy, cognitive behavioral therapy, and contingency management. Their findings suggest that a combination of these three modalities produces the best abstinence outcomes, although abstinence rates remain modest and decline after treatment. More recently, pharmacotherapy trials have been conducted as adjunctive interventions to psychosocial treatment. N‐acetylcysteine and gabapentin are two of the most promising medications, although no pharmacologic treatment has emerged as clearly efficacious. In this review, we provide a detailed summary of clinical trials that evaluated psychotherapy and pharmacotherapy for treating CUD and discuss emerging areas of clinical research and cannabis‐specific barriers to treatment.
Fabrication and characterization of Au/Zn composite electrode on p‐CdZnTe (111) B plane
Authors: Liang Xiao‐yan , Min Jia‐hua , Yang Liu‐qing , Zhang Ji‐jun , Wang Lin‐jun , Zhao Yue 
Published: March 2016

AbstractElectrode fabrication is a key procedure for preparation of high‐performance CdZnTe detectors, and the metal–semiconductor contact contributes greatly to the performance of detectors. In the present paper, a vacuum evaporation method was used to deposit a Au/Zn composite electrode on the (111) plane of p‐CdZnTe. Based on the AFM, SEM, current–voltage testing and the barrier‐height calculations, the effects of an Au/Zn contact on CdZnTe detector properties were investigated. The results showed that a lower Schottky barrier height was attained by depositing a Au layer on p‐CdZnTe(111) A plane and a Au/Zn double layers on (111) B plane, decreasing the influence of the Te‐enriched surface on the metal–semiconductor contact, and suggesting a better ohmic contact for CdZnTe detectors. (© 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A Dinuclear Ruthenium(II) Schiff Base Complex with Dissimilar Coordination: Synthesis, Characterization, and Biological Activity
Authors: Kahrović Emira , Zahirović Adnan , Turkušić Emir , Bektaš Sabaheta 
Published: March 2016

AbstractA dinuclear Schiff base RuII complex derived from 5‐chlorosalicylaldehyde and 2‐aminopyridine was synthesized. The structure of the compound was analyzed by mass spectrometry as well as IR, UV/Vis, and 1H NMR spectroscopy, along with chemical analysis,as well as magnetic, cyclovoltammetric and conductivity measurements. Two RuII atoms are octahedrally coordinated by azomethine and pyridine nitrogen atoms from two tridentate monobasic Schiff bases and bridging phenol oxygen atoms. The formula of the complex is [Ru2L2Cl2(Et2NH)(H2O)] [L = N‐(2‐pyridyl)‐5‐chlorosalicylideneimine and Et2NH = isodiethylamine]. The RuII atoms in the dinuclear neutral complex species have different coordination environments, RuN3O2Cl and RuN2O3Cl. Interaction with CT DNA showed moderate hydrophobic binding. The compound demonstrates strong activity against methicillin‐resistant Staphylococcus aureus, methicillin‐sensitive Staphylococcus aureus, and especially Enterococcus faecalis. Microbiological tests showed significant inhibition of growth and ability to kill pathogens, similar or even improved compared to reference antibiotics vancomycin.
Erythrocyte‐mediated delivery of recombinant enzymes
Authors: Leuzzi Vincenzo , Rossi Luigia , Gabucci Claudia , Nardecchia Francesca , Magnani Mauro 
Published: March 2016

AbstractThe possibility to clone, express and purify recombinant enzymes have originated the opportunity to dispose of a virtually infinite array of proteins that could be used in the clinics to treat several inherited and acquired pathological conditions. However, the direct administration of these recombinant proteins faces some intrinsic difficulties, such as degradation by circulating proteases and/or inactivation by the patient immune system. The use of drug delivery systems may overcome these limitations. Concerning recombinant enzyme therapy, the present review will mainly focus on the exploitation of erythrocytes as a carrier system for enzymes removing potentially noxious metabolites from the circulation, either as limiting treatment strategy for auxotrophic tumours or as a detoxing approach for some intoxication type inherited metabolic disorders. Moreover, the possibility of using RBCs as a potential delivering system addressing the enzymes to the monocyte–macrophages of reticular endothelial system for the treatment of diseases associated with this cell lineage, e.g. lysosome storage diseases, will be briefly discussed.
Physical Characteristics of Peanut Butter Influenced by Fully Hydrogenated Flixweed Seed Oil (Descurainia sophia L.) as a Stabilizer
Authors: Ahmadi Latifeh , Shahmir Fariba 
Published: March 2016

AbstractThe functional benefits provided by flixweed seed oil (FSO) warrant its application as an alternative to current commercial stabilizers used in peanut butter. The extracted FSO was fully hydrogenated and added to the lab‐made peanut butter in quantities of 1, 1.5, and 2 % (w/w). Samples were stored at 4, 21, and 40 °C, and tested at 2, 6, 16, and 24 weeks for oil separation tests and texture characteristics including hardness, adhesiveness, cohesiveness, and gumminess. Fully hydrogenated flixweed seed oil (FHFO) improved the oil holding capacity of peanut butter at 1, 1.5 and 2 % (w/w). Peanut butter containing FHFO, at a quantity of 2 % (w/w), showed the least oil separation and had comparable or less oil separation than the sample containing 1.5 % commercial stabilizer. Other physical properties were comparable between these two samples.
The Relationship Between Body Image and Domains of Sexual Functioning Among Heterosexual, Emerging Adult Women
Authors: Quinn-Nilas Christopher , Benson Lindsay , Milhausen Robin R. , Buchholz Andrea C. , Goncalves Melissa 
Published: March 2016

Abstract

Introduction
Research suggests that body image affects sexual functioning, but the relationship between specific types of body image (evaluative, affective, and behavioral) and domains of sexual functioning (desire, arousal, and orgasm) has not been investigated.

Aim
To determine whether, and to what degree, body image concerns (evaluative, affective, and behavioral) influence aspects of women’s sexual functioning (desire, arousal, and orgasm).

Methods
Eighty-eight sexually active women in heterosexual romantic relationships completed surveys assessing evaluative, affective, and behavioral body image and sexual functioning. Body composition data also were collected using dual energy x-ray absorptiometry.

Main Outcome Measures
Sexual functioning was assessed using the desire, arousal, and orgasm subscales of the Female Sexual Functioning Index.

Results
Hierarchical multiple regression analysis indicated that poor evaluative, affective, and behavioral body image were detrimental to women's sexual functioning. Specifically, dissatisfaction with one's body predicted decrements in desire (β = −0.31, P &lt; .05) and arousal (β = −0.35, P &lt; .01). Similarly, feeling that others evaluate one's body negatively predicted decrements in desire (β = 0.22, P &lt; .05) and arousal (β = 0.35, P &lt; .01). Feeling negatively about one’s appearance predicted decrements in arousal (β = 0.26, P &lt; .05). Negative thoughts and feelings about one’s body during a sexual encounter (body image self-consciousness) predicted decrements in arousal (β = −0.37, P &lt; .01) and orgasm (β = −0.25, P &lt; .05).

Conclusion
Findings from this study suggest important linkages between body image and sexual functioning constructs and indicates that interventions to improve body image could have concomitant benefits related to sexual experience.
A life‐cycle perspective of professionalism in services
Authors: Lawrence Benjamin , Zhang Jie J. , Heineke Janelle 
Published: March 2016

AbstractIn this article, we develop a professional service life cycle model to describe the changes in professional work over time. We explore the drivers of these changes through an in‐depth longitudinal case study of one specific professional service – Leadership in Energy & Environmental Design (LEED) consulting. We focus on understanding the evolutionary path of LEED consulting work as a result of its knowledge base, community and response to market and technological forces. Case evidence demonstrates an inherent tension between innovation and commodification resulting from multiple demands through various developmental stages. The life cycle model has important implications for value‐creation in professional service operations management. First, it broadens the theoretical investigation of professional services to consider all processes and people along the professional continuum – from most innovative to commodified. Coordinated effort along the professional continuum is the key to delivering both effectiveness and efficiency. Second, proactively managing the transitions along the evolutionary path is both possible and desirable. Standardization and specialization improve talent allocation and boost future innovation. We suggest future opportunities to test and enrich the model.