bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrencia y tamizaje de cáncer de mama: reporte de caso en paciente HER2+
Authors: Avila-Monteverde Enrique , Vásquez-Galaz Alexia M. , Névarez-López Ana C. , Sánchez-González Ángel M. , Montiel-Celaya Sofía 
Published: October 2024

El cáncer de mama es una enfermedad maligna caracterizada por crecimiento anormal del tejido mamario. Es la neoplasia más prevalente y mortal en México. El diagnóstico se fundamenta en la exploración física, ultrasonido y mastografía. El tamizaje se inicia a los 40 años. El tratamiento es multidisciplinario e incluye: cirugía radical o conservadora con disección ganglionar axilar o ganglio centinela, radioterapia, quimioterapia, entre otras. El riesgo de recurrencia es prolongado y persiste durante más de una década tras el tratamiento.
Se presenta el caso de una mujer de 51 años con antecedentes familiares de cáncer de mama y antecedentes de cuadrantectomía, laparoscopía por endometriosis y resección de nódulos mamarios. Experimentó recurrencia del cáncer de mama que llevó a mastectomía radical izquierda y ocho ciclos de quimioterapia. Se destaca la rápida recurrencia posterior a la última valoración de seguimiento.
Se realizó una revisión de las Guías de Práctica Clínica del Centro Nacional de Excelencia Tecnológica en Salud (CENETEC) y se consultaron bases de datos como PubMed, Scielo e INEGI. El enfoque fue retrospectivo, analizando los expedientes médicos y resultados de laboratorio de la paciente. Se resalta la importancia de la detección temprana y seguimiento adecuado en pacientes con antecedentes de importancia.
Abstract
Generalized pustular psoriasis (GPP) is a multisystem, acute and severe variant of psoriasis with a clinical presentation of erythematous and edematous plaques on which multiple pustules appear. Systemic manifestations are frequent and often severe. Complications that can develop include sepsis and kidney, liver, respiratory, and heart failure. 50% of patients require hospitalization. Reported mortality rates are 2 to 16%.
We present the case of a 21-year-old female patient with history of plaque psoriasis, located in the lower extremities, with 3 years of evolution and with poor adherence to treatment based on topical steroids. The patient began suffering from the condition 48 hours prior to her admission to the emergency department with pustular, painful, erythematous-based lesions that covered 100% of the total body surface, in addition to multiple systemic conditions such as shock, tachycardia, tachypnea, hypotension and fever. The diagnosis of GPP was confirmed by the skin biopsy that reported morphological changes consistent with psoriasiform dermatitis. Treatment with vasopressors and biological agents was initiated, achieving remission of the clinical case.
تمييز جريمة الإرهاب عن الجريمة العادية دراسة فقهية مقارنة -
Authors: ا م د منذر عبيس متعب  
Published: October 2024

الحمد لله رب العالمين وصلى الله على محمد واله الطاهرين الهداة الميامين.
من نعم الله تعالى على خلقه نعمة الامن التي بفقدها تفقد الحياة اهم مقوم من مقوماتها. ولما كنا في زمن تشعبت فيه أسباب تهديد الامن وتكثرت عنواناتها بل صار الخطر امرا واقعا بسبب الجرائم الإرهابية التي انتشرت في بقاع الأرض وابتلي مجتمعنا بالثقل الأكبر منها ، فقد صار لزاما على كل من يمتلك وسيلة لمواجهة هذا الخطر ان يتصدى دفاعا عن الامة ومقدساتها وعن وجوده الشخصي ومصالحه .
ومن اهم وسائل المواجهة هي كشف وبيان حقيقة الإرهاب بعدما حاول أعداء الإسلام واعداء الإنسانية نسبته الى الإسلام الحنيف والفكر الديني، وكذلك بيان سبل مواجهته والتشريعات الجزائية التي تعالجه، ولما كنا في بلد يعاني من اثار هذا البلاء المدمر ونحن نعيش في مرحلة التاسيس لدولة تمتلك مقومات الدولة المعاصرة وتحترم عقيدة شعبها وانتماءه فان من الضروري بيان رأي الشريعة الإسلامية في توصيف جريمة الإرهاب وتمييزها عن الجناية العادية؛ وموقف القانون الوضعي منها .
ولهذه الاهمية فقد اخترت موضوع تمييز جريمة الإرهاب عن الجريمة العادية، للبحث كمساهمة في المؤتمر العلمي الثاني الذي تقيمه كلية الامام الكاظم عليه السلام العتيدة المباركة.
وقد انتظم البحث في مبحث تمهيدي يتناول مفهوم الإرهاب في اللغة واصطلاح فقهاء المسلمين والقانون الوضعي، والمقارنة بين الحرابة والإرهاب في انطباق التوصيف على الجريمة، ومبحث اول تناول خصائص جريمة الإرهاب عند فقهاء المسلمين لمختلف المدارس الفقهية وفي القانون الوضعي ، ومبحث ثان تناول خصائص مرتكب جريمة الإرهاب ؛ مركزا على فقه مدرسة اهل البيت صلوات الله عليهم و قانون العقوبات العراقي وقانون الإرهاب النافذ ، ثم يستعرض نتائج المباحث ويثبت التوصيات التي تسهم في معالجة هذه الظاهرة الخطيرة.
والحمد لله رب العالمين وصلى الله على محمد وال محمد
والسلام عليكم ورحمة الله وبركاته
Electroconvulsive Therapy Regulates the Interhemispheric Functional Connectivity of the Dorsomedial Prefrontal Cortex in Depressive Patients: Evidence from 2 Independent Samples
Authors: Zhang Loufeng , Guo Yuanyuan , Bai Tongjian , Zu Meidan , Wei Qiang , Wu Yue , Ji Gongjun , Lv Huaming , Xie Wen , Wang Kai , Tian Yanghua , Su Jingyong 
Published: October 2024

Background: The dorsomedial prefrontal cortex (dmPFC) is considered a crucial node in emotional and cognitive processes. Voxel-mirrored homotopic connectivity (VMHC) is a validated methodology for investigating interhemispheric coordination. This study aims to elucidate the effects of electroconvulsive therapy (ECT) on the interhemispheric connectivity of the dmPFC in patients with depression, using VMHC as a measure of bilateral neural coordination.
Methods: Thirty-three patients with depression, screened at the University of Science and Technology of China (USTC), and thirty-five patients with depression, screened at Anhui Medical University (AHMU), were selected as the subjects of this study. VMHC was employed to investigate the effects of ECT on bilateral hemispheric functional connectivity. The Hamilton Depression Rating Scale (HAMD) was used to assess depressive symptoms, and the relationships between changes in HAMD scores and VMHC values were examined.
Results: Following ECT, the depressive symptoms of all participants decreased (p < 0.001). The VMHC values in the dmPFC were significantly increased in both groups after ECT (p < 0.01). No significant correlation was found between the increasing VMHC values in the dmPFC and the changes in HAMD scores in depressed patients (p > 0.05).
Conclusion: These results show that ECT regulates interhemispheric functional connectivity in depressed patients, and significantly increases the VMHC values in the dmPFC. Our findings may provide a useful method for optimizing the treatment of depression.
Prevalence and Correlations of Premenstrual Dysphoric Disorder: A Sample of Adult Working Women
Authors: Wu Heng , Yang Yang , Shen Weichen 
Published: October 2024

Background: Premenstrual dysphoric disorder (PMDD) represents a significant psychiatric condition affecting women of reproductive age. It is characterized by cyclical emotional and physical symptoms that considerably impair psychosocial functioning. This study aims to investigate the prevalence of PMDD among adult working women and identify associated etiological factors.
Methods: From January 2022 to March 2022, a cross-sectional study utilizing cluster sampling methodology was conducted to investigate the prevalence of PMDD among adult working women in six communities in Hangzhou (China). A total of 1710 participants were selected for research through a questionnaire-based survey. To elucidate the factors associated with PMDD, logistic regression analysis was employed.
Results: Among 1710 working women, 52 had PMDD, representing an incidence of 3.04%. Age (odds ratio (OR) = 3.196, p = 0.002), age at menarche (OR = 0.362, p = 0.011), income (OR = 0.449, p = 0.043), menstrual cycle (OR = 2.352, p = 0.022), menstrual symptoms (OR = 0.317, p = 0.003), physical activity (OR = 2.234, p = 0.028), and caffeine intake (OR = 2.318, p = 0.022) were independent influencing factors of PMDD in adult working women.
Conclusions: The study highlights that PMDD, which has a prevalence of 3.04% in the surveyed population, is a notable concern among adult working women. Key factors, such as age, age at menarche, income level, menstrual cycle characteristics, menstrual symptom presence, physical activity, and caffeine intake, significantly contribute to the likelihood of developing PMDD. These findings underscore the importance of recognizing and monitoring the above risk factors by clinicians to identify and manage PMDD in working women.
Calycosin-7-O-β-D-Glucoside Ameliorates Palmitate-Induced Lipid Accumulation in HT22 Cells
Authors: Xu Yanming , Li Dalong , Xue Ao , Gu Jiaming , Ren Yifan , Zhu Siyu , Lei Xia , Liu Jianxin , Zhao Jihui , Geng Fang , Zhang Ning 
Published: October 2024

Background: The pathogenesis of Alzheimer's disease (AD) is complex. Recent research suggests that AD patients have early disorders in brain cholesterol metabolism. Cholesterol and its derivatives accumulate in neurons, leading to p-Tau overproduction and synaptic dysfunction, initiating AD progression. Calycosin-7-O-β-D-glucoside (CG), a distinctive constituent of Astragali Radix, holds a representative position. Many clinical trials have demonstrated that CG can attenuate cerebral ischemia/reperfusion injury and preserve the structural integrity of the blood-brain barrier. However, whether CG alleviates tau-mediated neurodegeneration by increasing cholesterol efflux after lipid accumulation remains unexplored.
Methods: Ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) and multivariate data analysis were employed to investigate metabolic changes in HT22 cells induced by sodium palmitate following 24 hours of CG treatment. The potential therapeutic mechanisms of CG on AD were further examined through Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis.
Results: Metabolomic analysis characterized 24 potential biomarkers, revealing that CG could ameliorate cholesterol metabolic pathways. The results of cell experiments revealed that CG can increase the expression of enzyme cholesterol 24-hydroxylase (CYP46A1) (p < 0.05) and the level of 24 hydroxycholesterol (24-OHC) (p < 0.05), reduce the expression of p-Tau (Thr231)/Tau (p < 0.01), inhibit the formation of lipid droplets.
Conclusion: CG may inhibit the accumulation of cholesterol and its derivatives in neurons by affecting the CYP46A1-CE-Tau axis, offering a potential therapeutic strategy for AD.
The Relationship between Campus Bullying and Depression: The Mediating Role of Personality
Authors: Ni Xiaomin , Yin Changchun , Gao Ru 
Published: October 2024

Background: School bullying and depression have a great negative psychological impact on college students, and personality analysis is the key to the detection of psychopathological states. Therefore, this study aimed to explore the mediating effect of school bullying on depression and personality in college students.
Method: This cross-sectional study investigated the bullying situation in colleges and universities by using the Olweus Scale, the Self-Rating Depression Scale (SDS) and the Eysenck Personality Questionnaire. The participants were 1200 college students. Spearman correlation analysis was used to analyze the data and the mediating effect of exposure, and the mediating effect was tested.
Results: Spearman correlation analysis showed that bullying experience was associated with introversion (r = 0.702), neuroticism (r = 0.219) and depressive symptoms (r = 0.600), but was negatively correlated with extraversion (r = –0.537). Depressive symptoms were positively correlated with neuroticism (r = 0.279) and introversion (r = 0.611), but negatively correlated with extraversion (r = –0.469). In relationship between bullying and depression, neuroticism showed positively partially mediating effect and mediating effect ratio was 4.39% (β = 0.161, p < 0.05), and introversion had an obvious mediating effect and the ratio was 40% (β = 0.611, p < 0.001). Otherwise, extraversion partially mediated between campus bullying and depression adversely and mediating ratio is 8.75% (β = –0.359, p < 0.05).
Conclusion: Campus bullying is significantly associated with depression and personality, and personality has a remarkable mediating effect in campus bullying and depression.
ĐÁNH GIÁ MỨC ĐỘ PHÁT THẢI KHÍ NHÀ KÍNH TỪ HOẠT ĐỘNG CANH TÁC LÚA TRÊN ĐỊA BÀN TỈNH BẮC GIANG VÀ ĐỀ XUẤT GIẢI PHÁP QUẢN LÝ
Authors: Hoàng Tú Linh , Bùi Thị Thu Trang 
Published: October 2024

Bài báo trình bày kết quả tính toán mức độ phát thải khí nhà kính từ hoạt động canh tác lúa trên địa bàn tỉnh Bắc Giang, đồng thời đề xuất một số giải pháp nâng cao hiệu quả trong việc giảm phát thải khí nhà kính trong lĩnh vực trồng lúa tại khu vực, dựa vào phương pháp thu thập số liệu tính toán theo hướng dẫn của IPCC 2006 về kiểm kê khí nhà kính quốc gia, báo cáo kỹ thuật đóng góp do quốc gia tự quyết định của Việt Nam 2020. Tổng lượng phát thải khí nhà kính CH4 trong lĩnh vực trồng lúa năm 2022 tỉnh Bắc Giang là 25.548 tấn CH4/năm. Trong giai đoạn 2018 - 2022, lượng phát thải có xu hướng giảm từ 27.133 tấn CH4/ năm xuống còn 25.548 tấn CH4/ năm. Trong đó, huyện Lục Nam có lượng phát thải lớn nhất (4.181 tấn CH4/ năm), tiếp theo đó là huyện Hiệp Hoà (4.153 tấn CH4/năm). Khu vực có lượng phát thải nhỏ nhất là huyện Lục Ngạn (392 tấn/ năm). Tổng lượng phát thải dự tính năm 2030: Tổng phát thải CH4 từ canh tác lúa của tỉnh Bắc Giang là 25.247 tấn CH4; Kết quả tính toán phát thải CO2tđ, năm 2022, tổng lượng phát thải CO2tđ từ hoạt động canh tác lúa trong tỉnh Bắc Giang đã đạt mức 712.836 tấn CO2tđ/năm. Dự báo phát thải năm 2030, tổng phát thải CO2tđ là 706.915,8 tấn CO2tđ, giảm 5.921 tấn CO2tđ so với năm 2022. Phát thải trong lĩnh vực trồng lúa có xu hướng giảm là do chính sách chuyển đổi mục đích sử dụng đất của huyện, từ đất trồng lúa sang đất trồng cây ăn quả và đất thổ cư. Nghiên cứu đã đề xuất các biện pháp phù hợp đối với việc canh tác lúa tại khu vực: Giải pháp kỹ thuật tưới nước - khô xen kẽ (AWD), quản lý cây trồng tổng hợp (ICM), thay thế phân Ure bằng phân SA, sản xuất than sinh hoạt từ phế phẩm và rút nước giữa vụ. Điều này thực sự rất cần thiết cho hoạt động canh tác lúa nhằm giảm thiểu tối đa lượng phát thải khí nhà kính tại khu vực nói chung và ngành trồng lúa nói riêng.
Plastic Pollution Unveiled: Causes, Impacts, and Effective Prevention Methods
Authors: Shinwari Saifullah , Mukhlis Sifatullah , Elmi Fazalkarim , Mirzakhil Attullah , Kochai Khdaidad , Sharafmal Din mohammad , Ihsan Ihsanullah 
Published: October 2024

‌‌Environmental pollution is considered a global issue nowadays and immense efforts are being made to prevent it. Plastic pollution has become one of the most pressing environmental issues as plastics are accumulating worldwide on land and in oceans due to rapid population growth and urbanization. The amount of plastic garbage created has grown due to the fast population development, creating significant problems for its disposal. Plastic products are made up of various elements such as carbon, hydrogen, oxygen, nitrogen, chlorine, and sulfur. Plastics and natural materials such as rubber or cellulose are composed of very large molecules, or polymers, through a process called polymerization. Plastics are produced under specific and appropriate temperature and pressure conditions, additional plastics from industrial and municipal sources have caused headaches for agencies tasked with handling them. There are various methods for processing these materials. Various common methods to prevent plastic pollution have been investigated through this literature research. The result of the research revealed that there are two common ways to prevent the pollution of plastic products, one of which is to bury them and burn them, and the second way is the process of recycling, which can be used as a secondary product, gas, or oil. It can serve as an energy source.
Pedal Vessel Calcification and Risk of Major Adverse Foot Events in the Diabetic Neuropathic, Nephropathic Foot
Authors: Jones Michael A. , Bullock Garrett S. , Crowfoot Meghan M. , Sinacore David R. 
Published: October 2024

Background: We aimed to determine the relative risk of pedal vessel calcification (PVC) on major adverse foot events (MAFEs) and chronic kidney disease (CKD) stage in patients with diabetes mellitus (DM) and peripheral neuropathy (PN).
Methods: We retrospectively reviewed electronic medical records of 152 patients with diagnoses of DM, PN, and CKD stages one to five who had at least one foot radiograph obtained. PVC was scored (from 0–4) based on foot anatomic location and radiology reported MAFEs, which includes foot fracture, Charcot neuroarthropathy, foot ulcer, osteomyelitis, or minor amputation. Risk ratios (RR) with 95% confidence intervals (95% CI) and Poisson regressions were performed assessing the risk of sustaining MAFEs with number of PVCs and stage of CKD.
Results: The risk of any MAFE increased as PVC score increased (RR = 1.23); the risk of any MAFE increased as CKD stage increased (RR = 1.35); and risk of any PVC increased as CKD stage increased (RR = 1.71).
Conclusions: Pedal vessel calcification on a foot radiograph increases the risk of any MAFE and increases with progressive stage of CKD. Pedal vessel calcification may serve as a gateway to prompt investigation, treatment, or referral for at-risk diabetic neuropathic, nephropathic patients.
Phase relationship between ULF waves and drift‐bounce resonant ions: A statistical study
Authors: Ren Jie , Zong Q. G. , Zhou X. Z. , Rankin R. , Wang Y. F. , Gu S. J. , Zhu Y. F. 
Published: June 2017

AbstractWe explore the phase relationship between the poloidal mode ULF wave electric field oscillations and drift‐bounce resonant oxygen ions under the resonant condition of N = 2 at the magnetic equator. Using Cluster data from 2001 to 2004, we identify 55 fundamental poloidal mode wave events, among which 42 show “negative slope” pitch angle dispersion signatures in the southern hemisphere, 11 show “positive slope” dispersion in the northern hemisphere, and two near‐equatorial events are associated with in‐phase field‐aligned signatures. For each event, the off‐equatorial resonant ions are traced along their bouncing trajectories to determine the last time they moved across the equator. The resulting time series of the resonant oxygen ion fluxes at the equator are found to be statistically in antiphase with the wave electric fields. The resonant ion flux variation depends on both ion energy change and radial transportation. This antiphase relationship in statistics suggests two possibilities: (1) the fundamental poloidal mode wave electric fields are generally characterized by electric field intensity peaking near the magnetic equator if the flux variation is mainly caused by energy change and (2) the radial gradient of phase space density is positive if the flux variation caused by radial transportation is dominant.
Development of upwelling on pathway and freshwater transport of Pearl River plume in northeastern South China Sea
Authors: Chen Zhaoyun , Jiang Yuwu , Liu James T. , Gong Wenping 
Published: June 2017

AbstractIn situ observations, satellite images, and numerical modeling results have shown that the Pearl River plume axis extends alongshore and passes through two separate upwelling regions—one off the Guangdong and Fujian coasts (the Yuedong upwelling) and the other in the Taiwan Bank during the initial and medium stages of the Yuedong upwelling, while it is directed offshore when the Yuedong upwelling is strong. Model experiments are conducted to examine the effects of wind strength and baroclinicity on the upwelling and the corresponding pathway and freshwater transport of the Pearl River plume. The baroclinic effect is important to intensifying the horizontal velocity at the upwelling front and freshwater transport in the northeastern South China Sea. The freshwater transport flux is further decomposed into advection, vertical shear, and tidal pumping components, and advection is the dominant contributor. As the Yuedong upwelling develops, the zone with a relatively high‐pressure gradient moves offshore due to offshore Ekman transport and the shift in the upwelling front, which is responsible for the offshore transport of the river plume. When the river plume is transported to the outer‐shelf, sometimes it can be further entrained into eddies, allowing its export to the open sea.
Mineralogy of an active eolian sediment from the Namib dune, Gale crater, Mars
Authors: Achilles C. N. , Downs R. T. , Ming D. W. , Rampe E. B. , Morris R. V. , Treiman A. H. , Morrison S. M. , Blake D. F. , Vaniman D. T. , Ewing R. C. , Chipera S. J. , Yen A. S. , Bristow T. F. , Ehlmann B. L. , Gellert R. , Hazen R. M. , Fendrich K. V. , Craig P. I. , Grotzinger J. P. , Des Marais D. J. , Farmer J. D. , Sarrazin P. C. , Morookian J. M. 
Published: June 2017

AbstractThe Mars Science Laboratory rover, Curiosity, is using a comprehensive scientific payload to explore rocks and soils in Gale crater, Mars. Recent investigations of the Bagnold Dune Field provided the first in situ assessment of an active dune on Mars. The Chemistry and Mineralogy (CheMin) X‐ray diffraction instrument on Curiosity performed quantitative mineralogical analyses of the <150 μm size fraction of the Namib dune at a location called Gobabeb. Gobabeb is dominated by basaltic minerals. Plagioclase, Fo56 olivine, and two Ca‐Mg‐Fe pyroxenes account for the majority of crystalline phases along with minor magnetite, quartz, hematite, and anhydrite. In addition to the crystalline phases, a minimum ~42 wt % of the Gobabeb sample is X‐ray amorphous. Mineralogical analysis of the Gobabeb data set provides insights into the origin(s) and geologic history of the dune material and offers an important opportunity for ground truth of orbital observations. CheMin's analysis of the mineralogy and phase chemistry of modern and ancient Gale crater dune fields, together with other measurements by Curiosity's science payload, provides new insights into present and past eolian processes on Mars.
Decarboxylative Aminocatalytic Cascade for the Synthesis of Dihydroxanthones
Authors: Albrecht Anna , Bojanowski Jan 
Published: June 2017

AbstractA novel decarboxylative aminocatalytic strategy for the synthesis of 4,4a‐dihydroxanthones is described. It was realized by employing dienamine activation and utilizes readily available β,β‐disubstituted enals and chromone‐3‐carboxylic acids as starting materials. A decarboxylation reaction is the key step of the cascade making the aminocatalyst turnover possible.magnified image
Development and characterisation of functionalised AL‐MCM‐41 reinforced caprolactam toughened DGEBA epoxy‐cyanate ester polymer nanocomposites
Authors: Jayasree Muthu Rajamani , Anandakumar Srinivasan , Alagar Muthukaruppan 
Published: June 2017

AbstractThe present work aims at the toughening of DGEBA epoxy‐cyanate ester hybrid with caprolactam and its subsequent reinforcement with different weight percentages of (1, 3, 5, and 7 wt%) 3‐glycidylpropoxytrimethoxysilane functionalized Al‐MCM‐41 (F‐Al‐MCM‐41) to fabricate F‐Al‐MCM‐41 reinforced caprolactam toughened DGEBA epoxy‐cyanate ester polymer nanocomposites. 1H NMR and 13C NMR data confirmed the formation of epoxy cyanate ester. Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) results ascertained the curing behaviour of polymer composites. Data from thermal and dielectric studies reveal that 7 wt% F‐Al‐MCM‐41 reinforced caprolactam toughened DGEBA epoxy‐cyanate ester exhibits superior thermal stability and dielectric constant than that of a neat composite. The SEM‐ EDAX analysis investigated the surface morphology of polymer composites. Data obtained from DMA showed that 7 wt% polymer nanocomposite possesses the highest storage modulus among the samples.