bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary Arterial Hypertension as a Predictor of Severity of Chronic Kidney Disease and Correlation with Its Various Stages
Authors: Sethi Mahim , Srinath K. M. , Madhu B. , Sethi Suresh Kumar , Singh Ankit 
Published: October 2024

Abstract

Background:
Pulmonary arterial hypertension (PAH) pulmonary hypertension (PH) presents a complex pathobiology. Individuals with end-stage kidney disease, particularly those undergoing hemodialysis (HD), face an elevated risk of PH development. Early identification of PH severity in chronic kidney disease (CKD) can facilitate timely interventions to mitigate cardiovascular mortality. Our study aimed to determine the prevalence of PAH in CKD patients and explored its association with different CKD stages.

Materials and Methods:
A hospital-based cross-sectional study involving 60 CKD patients was conducted. Pulmonary arterial pressures were assessed using Doppler echocardiography, and patients were stratified into groups based on PH severity.

Results:
In our study, 86.7% of CKD patients had PAH, and their mean pulmonary arterial systolic pressure (PASP) was 50.83 ± 9.779 mmHg. There was a significant increase in PH prevalence with advancing CKD stages (P < 0.001). Patients undergoing HD exhibited a substantial PH prevalence (63.5%) (P < 0.001) as compared to those receiving conservative treatment. Furthermore, pulmonary arterial pressures were greater in HD patients with an arteriovenous fistula (AVF) (44.2%) (P < 0.001) than in individuals with a femoral or jugular vein HD catheter.

Conclusion:
Nearly four-fifth of CKD patients had PAH. In addition, individuals undergoing dialysis with an AVF demonstrated significantly elevated pulmonary arterial pressures compared to those using a femoral or jugular vein HD catheter.
A Comparative Analysis to Evaluate the Outcome and Effectiveness of Increasing the Therapeutic Agents for the Treatment of Acne Vulgaris
Authors: Nagar Rahul , Rai Anamika 
Published: October 2024

Abstract

Background:
Acne vulgaris is a long-term inflammatory condition impacting the pilosebaceous units. The guidelines largely rely on expert opinions in light of certain facets of acne treatment. Before initiating our study, we conducted a prescription analysis involving 100 patients diagnosed with acne vulgaris. We noted that in the majority of these cases, the established guidelines were not adhered to. Therefore, we decided to conduct this study at our institute to see if there is any additional benefit of adding multiple drugs to the treatment regimen and to find out if there is a way to rationalize the same.

Materials and Methods:
For the study, 120 patients with acne vulgaris, graded 2 and 3 according to the Investigator’s Global Assessment (IGA) Scale, were enrolled and divided into four groups. Patients were followed up for 8 weeks with visits at 4, 6, and 8 weeks. Group A was given clindamycin gel, Group B was given clindamycin gel + benzoyl peroxide gel (BPO) (2.5%), Group C was given clindamycin gel + BPO gel (2.5%) + oral doxycycline 100 mg, and Group D was given clindamycin gel + BPO gel (2.5%) + oral isotretinoin 20 mg.

Results:
This study showed that combination therapy with isotretinoin showed maximum reduction in IGA as well as in the total number of inflammatory lesions. Group C had similar efficacy to combination therapy with Group D as the results were not significantly different.

Conclusions:
The guidelines recommend adhering to protocols, specifically reserving isotretinoin for cases of very severe and treatment-resistant acne.
Relationship between Nutritional Status and Activities of Daily Living on Geriatric Depression among the Elderly Attending Primary Health Centers in Southern Karnataka
Authors: Pragadesh R , Kulkarni Praveen , Basheer Sayana 
Published: October 2024

Abstract

Introduction:
The population of the planet is aging quickly. According to the World Health Organization, the percentage of elderly individuals above 60 years of age worldwide is predicted to be doubled, from 12% in 2015 to 22% by 2050. Depression is the most common psychiatric disorder among the elderly which has a larger influence on their physical and emotional well-being. It is important to recognize the unique physical and mental health issues experienced by older adults.

Materials and Methods:
A community-based analytical cross-sectional study was conducted among elderly above 60 years of age attending two Primary Health Centres in the field practice areas of JSS Medical College, Mysuru. Based on inclusion and exclusion criteria, 130 elderly people were selected. Pretested semi-structured questionnaire on sociodemographic characteristics was administered, and a Geriatric Depression Scale (short form), Mini Nutritional Assessment Scale of the elderly, and Katz scale of independence were used. Statistical tests such as the Chi-square test and Spearman’s correlation test were used.

Results:
The prevalence of geriatric depression was 34.6%. Along with that, 5% were malnourished and 60% were at risk of malnutrition. The prevalence of physical dependency was 10%. Malnutrition and daily living activities were significantly associated with depression. Nutritional status and daily living activities show a negative correlation with geriatric depression and among them, nutritional status shows significant negative correlation with geriatric depression.

Conclusion:
Most of the elderly with poor nutritional status were depressed. Proper nutrition and adequate physical activity can cause a reduction in depression among the elderly.
Awareness of Rehabilitation Services Related to Dysphagia among Speech-language Pathologist
Authors: Kumar Santosh , Singh Alok Kumar , Sharma Mukesh , Ranjan Rajesh 
Published: October 2024

Abstract

Background:
Feeding is the process which includes preparation of food in the mouth, sucking, munching, and swallowing. Dysphagia is a difficulty in swallowing. Speech-language pathologist (SLP) has an important role in the evaluation and rehabilitation of dysphagia.

Objective:
The objective of the study was to carry out the survey on awareness of rehabilitation services related to dysphagia among SLPs.

Methodology:
Fifty SLPs who have completed postgradation and have minimum 1 year of experience were selected for the study. A questionnaire having 10 closed-ended questions related to dysphagia was given to the participants. Responses were collected and analyzed.

Results:
SLPs were working in the different setups and have seen different types of cases. They have used a variety of instruments and techniques for the assessment and management of dysphagia.

Conclusion:
SLPs are there to help in dysphagia rehabilitation that addresses the requirement of dysphagia management. Management of dysphagia is a developing trend in states and SLPs accept this new trend and accountability of rehabilitation with this population.
Role of Cytokeratin 19 Fragment Antigen 21-1 (CYFRA 21-1) in Early Diagnosis of Oral Squamous Cell Carcinoma
Authors: Sayed Aneesa Banu , Hendre Anup , Gudur Anand , Kakade Satish 
Published: October 2024

Abstract

Objective:
Oral cancer is considered one of the most common and rising cancers in India. Cytokeratin (CK) 21-1 (CYFRA 21-1) fragments are known to be a potential biomarker for the detection and diagnosis of potentially malignant lesion disorders (PMLDs) and oral squamous cell carcinoma (OSCC). In this study, we estimated CYFRA 21-1 levels in tobacco abusers/smokers, PMLD patients, and OSCC patients and compared with the samples of healthy controls to estimate their role in early diagnosis of OSCC.

Materials and Methods:
Serum CYFRA 21-1 was done by sandwich ELISA method. The kits were purchased from Everon Life Sciences.

Results:
Serum CYFRA 21-1 levels were seen to be raised in the PMLD and OSCC groups when compared with the healthy controls.

Conclusion:
Serum CYFRA 21-1 levels were raised in PML and OSCC group when compared with the healthy control. CYFRA 21-1 can be used as an essential biomarker for an early diagnosis of OSCC.
A Study on the Outcome of Pediatric Traumatic Brain Injuries in a Rural Tertiary Care Facility
Authors: Kumar Bharat , Faheem Mohd , Singh Shailendra Pal , Yadav Anurag 
Published: October 2024

Abstract

Background:
Traumatic brain injuries are the leading cause of death and disability in children. Approximately 70%–80% of accidental deaths in the pediatric age group are directly attributable to injuries to the central nervous system.

Purpose:
To study the clinico-radiological outcome of traumatic brain injury in a pediatric population in a rural tertiary center.

Materials and Methods:
A total of 103 children with a diagnosis of traumatic brain injury who met the inclusion or exclusion criteria were considered for the study. Traumatic brain contusions, subdural hematoma, extradural hematoma (EDH), and skull fractures were treated either conservatively or surgically; accordingly, their Glasgow Coma Scale (GCS) at the time of initial presentation was compared with the GCS at discharge, and the cases were followed-up at 1 month and 3 months after discharge.

Results:
There were 56 males (54.37%) and 47 females (45.63%) with a male-to-female ratio of 81.19:1. The most common mode of injury was fall from height (n = 82, 79.61%), followed by road traffic accident (n = 20, 19.42%). The majority of patients presented with loss of consciousness (n = 76, 73.79%), followed by vomiting (n = 68, 66.02%) and ear nose throat bleeding. Mild traumatic brain injury with GCS = 13–15 was observed in 64 cases (62.14%); our series has a mortality of 1.94% (n = 2). A significant association between Glasgow Outcome Scale (GOS) and GCS was found in patients with fractures and EDH. A significant association between GOS and GCS was found in patients with contusions. Good recovery was more likely to be observed with higher GCS scores. GOS was significantly associated with GCS score on admission.

Conclusion:
The motility rate was 1.94% in the study population. Most patients had a GCS score of 13–15 with mild injuries. The outcome on radiological features such as fracture, EDH, and contusion was significantly associated with GCS score on admission.
ST-segment elevation myocardial infarction mimics: The differential diagnosis of nonacute coronary syndrome causes of ST-segment/T-wave abnormalities in the chest pain patient
Authors: Moak James H. , Muck Andrew E. , Brady William J. 
Published: October 2024

Abstract
The evaluation of adult patients suspected of ST-segment elevation myocardial infarction (STEMI) includes a focused history and examination, 12-lead electrocardiogram (ECG), and cardiac serum marker analysis. The ECG plays a pivotal role in the early diagnosis and management of STEMI. A number of ECG entities in this patient population will present with ST-segment elevation and other electrocardiographic abnormalities which can mimic STEMI. In this article, we review the most frequent STEMI mimic patterns, highlight their ECG characteristics, and compare these individual ECG entities to the electrocardiographic abnormalities present with STEMI.
The efficacy and application of tranexamic acid in emergency medicine: Emergency Medicine Association of Türkiye clinical policy- 2024
Authors: Aksel Gökhan , Çorbacıoğlu Şeref Kerem , İslam Mehmet Muzaffer , Şener Alp , Karaarslan Fatma Nur , Satıcı Merve Osoydan , Ademoğlu Enis , Çinpolat Resul , Akoğlu Haldun , Danış Faruk , Doğan Fatma Sarı , Kudu Emre , Kaya Murtaza , Ünal Emir , Kayayurt Kamil 
Published: October 2024

Abstract
The clinical policy of the Emergency Medicine Association of Türkiye (EMAT) provides guidance on the use of tranexamic acid (TXA) in emergency settings. TXA, an antifibrinolytic drug, is used to control bleeding by inhibiting plasminogen. Its applications have expanded from hemophilia and severe menstrual bleeding to include various forms of trauma and surgery-related bleeding. Despite its potential benefits, the use of TXA in emergency settings must be carefully evaluated due to its associated risks, including venous thromboembolism. This policy aimed to offer evidence-based recommendations on the indications and contraindications of TXA in different clinical scenarios encountered in the emergency departments. The guidelines were developed using the “Grading of Recommendations, Assessment, Development, and Evaluations” approach, incorporating systematic literature reviews, and expert consensus from the EMAT Research Committee. This document focuses on critical clinical questions regarding the efficacy and safety of TXA in situations such as gastrointestinal bleeding, multitrauma, traumatic brain injury, nontraumatic intracranial hemorrhage, hemoptysis, and epistaxis. By addressing these issues, the policy seeks to assist emergency physicians in making informed decisions about the use of TXA, ultimately aiming to improve the patient outcomes.
A Probabilistic Descent Ensemble for Malware Prediction Using Deep Learning
Authors: Kumar R. Vinoth , Suguna R. 
Published: October 2024

INTRODUCTION: Introducing a Probabilistic Descent Ensemble (PDE) approach for enhancing malware prediction through deep learning leverages the power of multiple neural network models with distinct architectures and training strategies to achieve superior accuracy while minimizing false positives. OBJECTIVES: Combining Stochastic Gradient Descent (SGD) with early stopping is a potent approach to optimising deep learning model training. Early stopping, a vital component, monitors a validation metric and halts training if it stops improving or degrades, guarding against overfitting.
METHODS: This synergy between SGD and early stopping creates a dynamic framework for achieving optimal model performance adaptable to diverse tasks and datasets, with potential benefits including reduced training time and enhanced generalization capabilities.
RESULTS: The proposed work involves training a Gaussian NB classifier with SGD as the optimization algorithm. Gaussian NB is a probabilistic classifier that assumes the features follow a Gaussian (normal) distribution. SGD is an optimization algorithm that iteratively updates model parameters to minimize a loss function.
CONCLUSION: The proposed work gives an accuracy of 99% in malware prediction and is free from overfitting and local minima.
Demographic and Clinical Features of Visceral Leishmaniasis in Chad: A Prospective Cross-Sectional Survey
Authors: Israël Demba Kodindo , Coulibaly Cheick Amadou , Joël Vourchakbé , Fesuh Nono Betrand , Vincent Gonnonta , Kamhawi Shaden , Doumbia Seydou 
Published: October 2024

ABSTRACT.
Visceral leishmaniasis (VL), caused by the protozoan Leishmania donovani complex, is endemic in many parts of the world. Little known in Chad, VL has been recently documented from previously nonendemic areas. We report an epidemiological investigation of VL in the Léré district hospital in southwestern Chad. After informed consent, 40 VL patients were enrolled in the study. Diagnosis made using the formalin serological test was confirmed by polymerase chain reaction on blood samples. Clinical parameters were obtained from the physician or nurse caregiver, and from patients. Of a total of 40 serology positive patients, L. donovani DNA was found in 33 (82.5%), with 55% being male patients. The most affected age groups were 15–29 (47.5%) and 0–14 (32.5%) years. Fever, weight loss, and pallor were frequent symptoms. Notably, splenomegaly and hepatomegaly were uncommon clinical signs. Common comorbidities included malaria (25%) and hepatitis B (15%), followed by gastric ulcer (10%) and tuberculosis (7.5%). These comorbidities were concurrent with VL and were diagnosed microscopically in blood and serum for malaria and tuberculosis, respectively, and by the rapid diagnostic test using serum for hepatitis B and gastric ulcer. Thirty-five percent of cases were treated with meglumine antimoniate, and three patients (7.5%), all with comorbidities, died. Sixty percent of patients lived close to the main town. Our data demonstrate that VL is endemic in the health district of Léré. Improving health education regarding L. donovani infection in endemic areas of Chad and providing training of health workers on early detection and management of VL are needed to help save lives.
Digital Literacy Practice: Pedagogical Approach with CoPORA Model on Students’ Performances in Writing Classroom
Authors: Hafidz Moh. , Retnaningdyah Pratiwi , Mustofa Ali 
Published: October 2024

Objective: This study aims to describe the impact of the CoPORA model on EFL university students’ performances in accessing, communicating, integrating, evaluating, and creating information using social media in a writing classroom. Method: Data were collected using interview techniques from EFL university students and analyzed descriptively to achieve the study's objectives. Results: The CoPORA model in pedagogical digital literacy practices enables students to master English vocabulary, be motivated to communicate, develop social identity, and manage and evaluate information effectively. Key performances included creating and communicating argumentative texts with readers on social media platforms. Social media usage facilitated checking trusted sources and contents, communicating information with friends, lecturers, and followers, making cross-references among digital content and facts, proving the truth of contents, and writing and communicating argumentative texts. Novelty: The study found that pedagogical digital literacy practices using the CoPORA model positively contribute to students' mutual contributions to language learning, cognition, and social interaction in English essay-writing classrooms.
Analysis of the Development of Image Media Use on Science Learning Outcomes in Primary Schools In the period 2018-2023
Authors: Meliyana Meliyana , Rohmani Rohmani 
Published: October 2024

Objective: Technological developments regarding image media have increased quite significantly in the last six years, where the impact of the use of visual media on science learning outcomes at both middle school and high school levels, especially elementary school, is very popular, and there has been an increase in research on both theses and SINTA articles. The goal of this study is to find out how much the usage of visual media affects science learning outcomes. Topics covered in elementary school. Method: A Systematic Literature Review (SLR) methodology is used in this investigation. This methodology makes the examination and synthesis of recent research findings in primary school education possible. Using the PRISMA methodology, the study carried out a systematic literature review, covering steps like identification, screening, eligibility assessment, and inclusion criteria. The literature sources covering 2018 to 2023 came from the Google Scholar or Google Scholar database. The conclusions of this research come from database searches carried out using the terms Image Media, Science Learning Results, and Primary School. Results: Once the literature search was completed, the analysis yielded ten articles that met the requirements for inclusion in the detailed analysis. This is selected and included. Novelty: To ensure students achieve the highest academic success, the application of appropriate media in learning science subjects in elementary grades can positively impact their learning activities.
Assessing Business Viability for a Production Joint Venture in the Indonesian Medical Device Industry
Authors: Maryadi Martya Putri , Damayanti Sylviana Maya 
Published: October 2024

Research Aims: This study examines the viability of a joint venture between Daenamic Health Inc., a South Korean medical device manufacturer, and PT. Kenari Jaya Perkasa, an Indonesian medical device importer, to establish a local production facility for high-end medical devices in Indonesia.
Design/methodology/approach: The research follows a structured approach involving the analysis of business model compatibility, external market dynamics, and the financial and operational viability of the joint venture. Employing qualitative analysis from discussions, VRIO Framework, and quantitative analysis from Analytic Hierarchy Process (AHP), the study evaluates market conditions and strategic fit between the partners.
Research Findings: Findings indicate that Daenamic Health Inc. and PT. Kenari possess complementary strengths, forming a synergistic partnership poised to become a leading local brand for high end medical technology, as well as enabling access to more export market. Motivated by the need to reduce Indonesia's dependency on import, especially highlighted during the COVID-19 pandemic, this venture aligns with government policies to enhance local manufacturing and healthcare infrastructure. However, challenges such as navigating regulatory landscapes, managing a layered cost structure, and training local human capital must be addressed.
Theoretical Contribution/Originality: Preliminary assessment for the joint venture’s establishment helps the partners to comprehensively assess their internal situation both as individual business and as future partners, prior to capitalizing the opportunity that comes with Indonesia’s vision towards healthcare self-sufficiency. As a result, partners’ synergistic strengths and aligned individual business needs positions the venture for competitive pricing and expansion in Southeast Asia and beyond.
Keywords: Medical Devices; Joint Venture; Local Manufacturing; Market Dynamics; Strategic Fit
Towards SDG Digital Quality Learning: a Conceptual DLR based Model for Online Language Encoding-Skill Enhancement
Authors: Jumanto Jumanto , Asmarani Rahmanti , Triwibowo Febri Dhani , Pamungkas Hery , Ramayanti Ismarita , Harunasari Siti Yulidhar , Adi AB Prabowo Kusumo 
Published: October 2024

Objectives: This present research has objectives to encourage digital quality learning as part of SDG quality education through proposing a DLR-based model on Zoom and WhatsApp as the main digital learning platforms for enhancing language encoding skills, i.e. the speaking and writing skills, within online learning activities. DLR refers to digital learning resources.

Method: This qualitative research model is interpretatively descriptive and digitally creative. The research design consists of a system model which consists of Input, Throughput or Process, and Output, with Zoom and WhatsApp as the main platforms, and other digital platforms as digital learning resources to support the endeavor. The Zoom main platform is mainly used for observing the spoken activities, while the other WhatsApp main platform is used for observing the written interactions or communication.

Results and Discussion: The novelty or the strengths of this presently proposed DLR-based model for enhancing the learners’ speaking and writing skills are on the comprehensive surveys to include the speaking and writing tests, on the learners’ online learning independence or their flexible ways or styles of online learning, on the equally sufficient opportunities for the learners’ speaking and writing activities, and on the inclusive and encouraging roles of the digitally-literate teachers.

Research Implications: The presently proposed DLR-based model is aimed at enhancing the speaking and writing skills within online learning platforms for any language learners or research subjects, not necessarily high-school teachers as the previous model suggested.

Originality/Value: This conceptual DLR-based model for learning language encoding skills is, therefore, promoting the world endeavor for digital quality learning, thus encouraging the quality education within the United Nations’ 17 Goals of Sustainable Development.