bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the effects of mobile bottom fishing on benthic carbon processing and storage: a systematic review protocol
Authors: Felgate Stacey L. , Aldridge John , Bolam Stefan G. , Breimann Sarah , de Borger Emil , Claes Jolien , Depestele Jochen , Epstein Graham , Garcia Clement , Hicks Natalie , Kaiser Michel , Laverick Jack H. , Lessin Gennadi , O’Neill Finbarr G. , Paradis Sarah , Parker Ruth , Pereira Ryan , Poulton Alex J. , Powell Claire , Smeaton Craig , Snelgrove Paul , Tiano Justin , van der Molen Johan , van de Velde Sebastiaan , Sciberras Marija 
Published: October 2024

Abstract
Background
Marine sediments represent one of the planet’s largest carbon stores. Bottom trawl fisheries constitute the most widespread physical disturbance to seabed habitats, which exert a large influence over the oceanic carbon dioxide (CO2) sink. Recent research has sparked concern that seabed disturbance from trawling can therefore turn marine sediments into a large source of CO2, but the calculations involved carry a high degree of uncertainty. This is primarily due to a lack of quantitative understanding of how trawling mixes and resuspends sediments, how it alters bioturbation, bioirrigation, and oxygenation rates, and how these processes translate into carbon fluxes into or out of sediments.

Methods
The primary question addressed by this review protocol is: how does mobile bottom fishing affect benthic carbon processing and storage? This question will be split into the following secondary questions: what is the effect of mobile bottom fishing on: (i) the amount and type of carbon found in benthic sediments; (ii) the magnitude and direction of benthic-pelagic carbon fluxes; (iii) the biogeochemical, biological, and physical parameters that control the fate of benthic carbon; and (iv) the biogeochemical, biological, and physical parameters that control the fate of resuspended carbon. Literature searches will be conducted in Web of Science, SCOPUS, PROQUEST, and a range of grey and specialist sources. An initial scoping search in Web of Science informed the final search string, which has been formulated according to Population Intervention Comparator Outcome (PICO) principles. Eligible studies must contain data concerning a change in a population of interest caused by mobile bottom fishing. Eligible study designs are Before and After, Control and Impact, and Gradient studies. Studies included at full-text screening will be critically appraised, and study findings will be extracted.Extracted data will be stored in an Excel spreadsheet. Results will be reported in narrative and quantitative syntheses using a variety of visual tools including forest plots. Meta-analysis will be conducted where sufficient data exists.
What does e-invoice data bring to SNA and real-time economy?
Authors: Akagi Kaya 
Published: October 2024

AbstractThis paper explores the potential of electronic invoice data to enhance the System of National Accounts (SNA) and facilitate a Real-Time Economy (RTE). The rise of data science and advancements in information and communication technologies have increased the use of big data in economic statistics. E-invoice data is being digitized in Europe to detect VAT fraud, but it also contains a vast amount of information on economic entities that make up the SNA. This study focuses on integrating electronic accounting information to improve the coverage, granularity, and update speed of SNA. The paper examines the concept of RTE, which emphasizes real-time data processing and automation, particularly in Estonia and Finland. It also highlights the benefits and challenges of using invoice data for economic statistics, including issues related to data storage formats, legislative systems, and the coordination of data linkages. The research demonstrates invoice data’s theoretical and practical applications for constructing Input–Output Tables (IOTs) and monitoring financial situations. Despite the technical and institutional hurdles, the study suggests integrating invoice data can significantly transform economic statistics.
Emerging and ecofriendly biological methods for agricultural wastewater treatment
Authors: Abonyi Matthew Ndubuisi , Obi Christopher Chiedozie , Nwabanne Joseph Tagbo , Aniagor Chukwunonso Onyeka 
Published: October 2024

AbstractThe quest for sustainable agricultural practices has led to a surge in research focused on innovative wastewater treatment methods. This review explores the emerging biological treatment approaches designed to address the challenges of eco-friendly agricultural wastewater treatment and subsequent reuse. The investigation centers around three novel techniques: constructed wetlands, algae-based systems, and microbial fuel cells. Constructed wetlands (CWs) mimic natural processes to treat agricultural wastewater, providing habitat for various plant species that collaboratively remove contaminants. Algae-based systems(ABs) harness the photosynthetic prowess of algae to absorb nutrients and pollutants, producing biomass that can be repurposed. Meanwhile, microbial fuel cells (MFCs) employ microorganisms to break down organic matter in wastewater while generating electricity as a valuable byproduct. This review aims to provide insights into the potential of these biological treatment methods to revolutionize wastewater management in agriculture. By mitigating environmental impact, conserving water resources, and yielding reusable outputs, these techniques will offer a sustainable pathway towards addressing the pressing challenges of agricultural wastewater treatment and enhancing the overall ecological balance.
BRD4 inhibitor reduces exhaustion and blocks terminal differentiation in CAR-T cells by modulating BATF and EGR1
Authors: Sui Songnan , Zhong Mengjun , Zhong Shuxin , Peng Xueting , Mao Lipeng , Chen Cunte , Zeng Chengwu , Luo Oscar Junhong , Li Yangqiu 
Published: October 2024

Abstract
Background
Exhaustion is a key factor that influences the efficacy of chimeric antigen receptor T (CAR-T) cells. Our previous study demonstrated that a bromodomain protein 4 (BRD4) inhibitor can revise the phenotype and function of exhausted T cells from leukemia patients. This study aims to elucidate the mechanism by which a BRD4 inhibitor reduces CAR-T cell exhaustion using single-cell RNA sequencing (scRNA-Seq).

Methods
Exhausted CD123-specific CAR-T cells were prepared by co-culture with CD123 antigen-positive MV411 cells. After elimination of MV411 cells and upregulation of inhibitory receptors on the surface, exhausted CAR-T cells were treated with a BRD4 inhibitor (JQ1) for 72 h. The CAR-T cells were subsequently isolated, and scRNA-Seq was conducted to characterize phenotypic and functional changes in JQ1-treated cells.

Results
Both the proportion of exhausted CD8+ CAR-T cells and the exhausted score of CAR-T cells decreased in JQ1-treated compared with control-treated cells. Moreover, JQ1 treatment led to a higher proportion of naïve, memory, and progenitor exhausted CD8+ CAR-T cells as opposed to terminal exhausted CD8+ CAR-T cells accompanied by enhanced proliferation, differentiation, and activation capacities. Additionally, with JQ1 treatment, BATF activity and expression in naïve, memory, and progenitor exhausted CD8+ CAR-T cells decreased, whereas EGR1 activity and expression increased. Interestingly, AML patients with higher EGR1 and EGR1 target gene ssGSEA scores, coupled with lower BATF and BATF target gene ssGSEA scores, had the best prognosis.

Conclusions
Our study reveals that a BRD4 inhibitor can reduce CAR-T cell exhaustion and block exhausted T cell terminal differentiation by downregulating BATF activity and expression together with upregulating EGR1 activity and expression, presenting an approach for improving the effectiveness of CAR-T cell therapy.
Evaluation of size-dependent uptake, transport and cytotoxicity of polystyrene microplastic in a blood-brain barrier (BBB) model
Authors: Cho Yeongseon , Seo Eun U , Hwang Kyeong Seob , Kim Hyelim , Choi Jonghoon , Kim Hong Nam 
Published: October 2024

AbstractMicroplastics, particularly those in the micrometer scale, have been shown to enter the human body through ingestion, inhalation, and dermal contact. Recent research indicates that microplastics can potentially impact the central nervous system (CNS) by crossing the blood-brain barrier (BBB). However, the exact mechanisms of their transport, uptake, and subsequent toxicity at BBB remain unclear. In this study, we evaluated the size-dependent uptake and cytotoxicity of polystyrene microparticles using an engineered BBB model. Our findings demonstrate that 0.2 μm polystyrene microparticles exhibit significantly higher uptake and transendothelial transport compared to 1.0 μm polystyrene microparticles, leading to increased permeability and cellular damage. After 24 h of exposure, permeability increased by 15.6-fold for the 0.2 μm particles and 2-fold for the 1.0 μm particles compared to the control. After 72 h of exposure, permeability further increased by 27.3-fold for the 0.2 μm particles and a 4.5-fold for the 1.0 μm particles compared to the control. Notably, microplastics administration following TNF-α treatment resulted in enhanced absorption and greater BBB damage compared to non-stimulated conditions. Additionally, the size-dependent toxicity observed differently between 2D cultured cells and 3D BBB models, highlighting the importance of testing models in evaluating environmental toxicity.
Graphical Abstract
Individual and community-level factors associated with adequate antenatal care service utilization in sub-Saharan Africa
Authors: Fenta Setegn Muche , Fenta Haile Mekonnen , Yilema Seyifemickael Amare , Chen Ding-Geng , Mekonnin Amsalu Worku 
Published: October 2024

Abstract
Background
Sub-Saharan Africa (sSA) continues to rank among the regions in the world with the highest rates of maternal mortality and the lowest rates of utilization of maternal health care. The risk of death for women in sSA is 268 times higher than that of women in high-income nations. Adequate antenatal care (ANC) services utilization is essential to the mother's and the baby's survival and well-being. This study aimed to identify both individual and community-level factors associated with adequate antenatal care services utilization in sSA.

Method
We used data from the most recent Health and Demographic Surveys (DHS), which were carried out between 2012 and 2022 in 33 sSA countries. A total of 240,792 women were included in this study. The two-level mixed-effects logistic regression model was used to identify the individual and community-level factors associated with the use of adequate ANC service.

Results
The pooled prevalence of adequate ANC service utilization in sSA was 55.48% (95% CI: 55.28–55.68). The study showed that secondary and above-educated women (AOR = 2.13, 95% CI 2.07–2.19, secondary and above-educated husbands (AOR = 1.55, 95% CI 1.51–1.60), rich women AOR = 1.26, 95% CI 1.24–1.29), women 35–49 years of age (AOR = 1.36, 95% CI 1.32–1.41) and distance to a health facility is not a big problem (AOR = 1.13; 95% CI 1.11–1.16) was significantly and positively correlated with the use of adequate ANC services. However, rural women (AOR = 0.80; 95% CI 0.78–0.82), not having mass media access (AOR = 0.74, 95% CI 0.72–0.75), 5 and above birth order (AOR = 0.73, 95% CI 0.68–0.78) were significantly and negatively correlated with the use of adequate ANC services. Additionally, the random effects model showed that variables at the community and individual levels were responsible for approximately 62.60% of the variation in the use of adequate ANC services.

Conclusion
The sSA countries had a low prevalence of adequate utilization of ANC with a significant variation among countries. Moreover, public health initiatives should focus on rural women, poor women, and uneducated women to enhance maternal health services utilization. Furthermore, policies and programs that address cluster variations in the utilization of adequate ANC services must be developed, and their implementation must be vigorously pursued.
The role of electronic health records in improving pediatric nursing care: a systematic review
Authors: Al-Shammari Moustafa A. , Jaafar Jaafar Sadiq , Elfeshawy Reda 
Published: October 2024

Abstract
Background
The adoption of electronic health records (EHRs) has revolutionized healthcare delivery, offering potential benefits for enhancing the quality and safety of pediatric nursing care. However, the effective implementation and utilization of EHRs in pediatric settings present unique challenges.

Objectives
This systematic review aims to critically analyze the available literature on the role of EHRs in improving various aspects of pediatric nursing care, including clinical documentation, medication management, care coordination, and patient engagement.

Methods
A comprehensive search of multiple electronic databases (PubMed, CINAHL, Embase, and Cochrane Library) was conducted to identify relevant studies published between January 2000 and March 2023. Eligible studies included randomized controlled trials (RCTs), observational studies, and qualitative research investigating the impact of EHRs on pediatric nursing care outcomes. Study selection, data extraction, and quality assessment were performed by two independent reviewers.

Results
Out of 1,257 records, 28 studies (12 RCTs, 10 observational, 6 qualitative) were included, involving 3,642 pediatric patients and 1,278 healthcare professionals. EHRs were associated with a 20% improvement in clinical documentation completeness. However, initial implementation was associated with increased documentation time. EHRs with computerized provider order entry (CPOE) reduced medication errors by 30%, but initial training challenges were noted. Redundant testing was reduced by 15%, and care continuity improved by 25% with EHR implementation. Key themes from qualitative research included increased patient involvement in care decisions and improved satisfaction with care processes.

Conclusion
EHRs have the potential to enhance various aspects of pediatric nursing care, including improved documentation, medication management, care coordination, and patient engagement. Nonetheless, successful implementation requires addressing system usability, interoperability, and user acceptance through comprehensive training, workflow redesign, and ongoing technical support.

Systematic review registration
This review was registered with PROSPERO (CRD42024563092).
Predictors of breast cancer HER2-receptor positivity by MRI intuitive imaging features
Authors: Bayoumi Dalia , ELagamy Ahmed Alaa EL-Din , Salem Hesham Sabry Mohamed , Elboghdady Aya 
Published: October 2024

Abstract
Background
Today, breast cancer is the most diagnosed cancer worldwide. There are many different clinical presentations, radiological characteristics, and histological types of breast cancer. HER2 is overexpressed in a significant number of breast cancer cases reaching 20% of all breast cancers, and its overexpression is seen directly proportionate with a poor outcome and prognosis.

Methods
We started this cross-sectional research from January 2022–December 2023 on 202 breast cancer patients who had 220 lesions. The molecular subtypes of the different lesions were determined in all the included cases. Magnetic resonance imaging (MRI) studies were conducted in all included cases. The MRI parameters included conventional MRI, diffusion-weighted analysis, and dynamic post-contrast T1-weighted imaging.

Results
The prevalence of irregular margins (P < 0.001), linear and segmental distribution (P = 0.044), heterogeneous pattern (P < 0.001), and type 2 curve was statistically significantly higher in the HER2-positive lesions. Nipple infiltration incidence showed statistically significant elevation in the HER2-positive lesions (P = 0.017). The lesions’ ADC and perilesional ADC in the HER2-positive lesions were also statistically significantly elevated. The best cutoff point of ADC to detect lesions with positive HER2 expression was > 0.885 × 10–3 mm2/s, with 65.7% sensitivity and 60% specificity, with a statistically significant value (p = 0.005).

Conclusions
Magnetic resonance imaging of breast imaging is a promising noninvasive method for identifying breast tumors with the HER2 molecular subtype. Combining various radiological features by MRI may provide a conclusion for recognizing positive HER2 lesions.
Necessity for a global patient co-owned cloud (GPOC)
Authors: Lidströmer Niklas , Davids Joe , ElSharkawy Mohamed , Ashrafian Hutan , Herlenius Eric 
Published: October 2024

Abstract
Background
The use of Cloud-based storage of personal health records has increased globally. The GPOC Series introduces the concept of a Global Patient co-Owned Cloud (GPOC) of personal health records. Here, we present the GPOC Series’ international survey on the necessity of a GPOC.

Methods
Online global survey with invitations sent to health ministries and major organisations. It received answers from health ministries and affiliated advisors of all 193 United Nations (UN) member states, 2 UN observer states (Holy See & Palestine) and 1 de facto UN non-member state (Taiwan) and from 18 major international organisations. The survey examined a dozen aspects encompassing demographics, privacy, sharing, movability, co-ownership, research, company usage, regulation and the necessity of a GPOC.

Results
The GPOC Survey elicited responses from 267 individuals from 214 entities, including all UN member states, and major international organisations. Twelve domains were identified, covering demographics, correctness, privacy, commercial use, medical and non-medical research, co-ownership, data sharing, record movement, ownership centralisation, patient rights, environmental concerns, and foundation creation. Results show high agreement on most issues, including support for co-ownership (89%) and movement of personal health records (84%). Disagreement was prominent regarding centralised ownership by the state (64%) and data sharing without consent (85%). Additionally, respondents expressed interest in a neutral, decentralised foundation for regulation (73%) and the environmental sustainability of electronic health records (84%).

Conclusions
A Global Patient co-Owned Cloud (GPOC) of personal health records could significantly enhance patient independence and involvement in health management, supported by the near consensus agreement across various domains identified in our survey. This consensus underscores the potential of GPOC to democratise healthcare and align with UN Sustainable Development Goals (SDGs). The survey results demonstrate strong support for GPOC’s role in promoting evidence-based patient management, reducing information silos, and fostering ethical data sharing. Moreover, the overwhelming agreement on key principles of co-ownership, data sharing, and environmental sustainability highlights the global inclination for a decentralised, patient-controlled PHR platform. This platform stands to empower patients worldwide, advance precision medicine, and contribute to the global development and dissemination of artificial intelligence in healthcare.
HIV-1 assembly – when virology meets biophysics
Authors: Lacouture Claire , Carrio Baptiste , Favard Cyril , Muriaux Delphine 
Published: October 2024

ABSTRACT
Cells naturally produce vesicles that bud from different lipid membranes using dedicated molecular machineries. Enveloped RNA viruses, including human immunodeficiency virus type 1 (HIV-1), also generate particles that bud from host cell membranes by hijacking cellular factors and signaling pathways similar to those involved in the budding of extracellular vesicles. HIV-1 buds from the host cell plasma membrane mainly via the self-assembly of Gag, a structural protein. Gag is a polyprotein that forms assembly complexes containing viral genomic RNA (gRNA), host cell lipids and proteins. HIV-1 Gag binds and segregates host cell plasma membrane lipids while self-assembling simultaneously on the gRNA and the plasma membrane. This self-assembly causes membrane bending and formation of a new viral particle with the help of host cell proteins, likely including cortical actin-associated factors. However, it is unclear whether the energy of Gag self-assembly is sufficient to generate new HIV-1 particles. In this Review, we discuss these processes in the light of the past and recent virology literature, incorporating lessons from studies on the quantitative biophysics of viral self-assembly, and explore how Gag might reorganize the plasma membrane and divert host cell membrane curving proteins and cortical actin-related factors to achieve particle assembly and budding.
Toxic Chief Executive Officers; Environmental, Social, and Governance Institutional Investors as Watchdogs; and the Labor Market Outcomes
Authors: Lel Ugur 
Published: October 2024

I examine changes in chief executive officer (CEO) labor market outcomes following corporate environmental failures. CEOs of firms subject to Environmental Protection Agency enforcements experience a decline in labor market opportunities as outside directors and a higher likelihood of dismissal as CEOs. They also receive less shareholder support in directorial elections. These effects are mostly visible in recent years and in firms with significant socially responsible investments (SRIs), and they are robust to using state environmental regulations for identification. Shareholders exhibit particular concern over environmental violations that may subject firms to future legal liabilities. Overall, these results point to significant reputational repercussions of environmental failures to CEOs and the disciplinary role of SRIs. This paper was accepted by Camelia Kuhnen, finance. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.02372 .
An Integrated Approach to Improving Itinerary Completion in Coordinated Care Networks
Authors: Liu Yiqiu , Shi Pengyi , Helm Jonathan E. , Van Oyen Mark P. , Ying Lei , Hucshka Todd 
Published: October 2024

Problem definition: Coordinated care network (CCN) is a burgeoning paradigm where patients’ diagnosis and treatment plans are developed based on collaboration between multiple, colocated medical specialties to holistically address patients’ health needs. A primary performance metric for CCNs is how quickly patients can complete their itinerary of appointments at multiple medical services in the network. Rapid completion is critical to care delivery but also presents a major operational challenge. Because information about a patient’s condition and treatment options evolves over the course of the itinerary, care paths are not known a priori. Thus, appointments (except for the first one) cannot be reserved in advance, which may result in significant delays if capacity is not allocated properly. Methodology/results: We study capacity allocation for the patient’s first (root) appointment as the primary operational lever to achieve rapid itinerary completion in CCNs. We develop a novel queueing-based analytical framework to optimize this root appointment allocation, maximizing the proportion of patients completing care by prespecified deadlines. Our framework accounts for the complex interactions among all patients in the network through the blocking process, which contrasts with conventional siloed planning. We provide an exact characterization of the itinerary time and develop a mean-field approximation with convergence guarantees that permits tractable solutions for large-scale network problems. In a simulation case study of Mayo Clinic, our solution improves on-time completion from 60% under the current plan to more than 93%. Managerial implications: We demonstrate that root appointment allocation is a multifaceted problem and that ignoring any of those facets can lead to poor performance. Simultaneously accounting for all of these complexities makes manual template design or traditional optimization methods inadequate, highlighting the significance of our integrated approach. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.0649 .