bluuebunny/crossref_metadata_2025_split huggingface dataset:
Die Kosten von MRSA in der stationären geriatrischen Versorgung von Patienten am Lebensende (End-of-Life Care)
Authors: Adelhardt Thomas , Hessemer Stefanie , Docter Katrin , Sieber Cornel , Ostgathe Christoph , Schöffski Oliver 
Published: May 2017

Zusammenfassung
Ziel Die vorliegende Studie beschäftigt sich mit der Frage, welche finanziellen Auswirkungen das Auftreten von MRSA in einer geriatrischen Abteilung eines deutschen Krankenhauses bei Patienten am Ende des Lebens hat. Dabei sollen die Hauptkostentreiber identifiziert sowie die Kosten beziffert werden.
Methodik Eine retrospektive Analyse in einem Zeitraum von einem Jahr wurde für eine geriatrische Abteilung in einem Krankenhaus der Schwerpunktversorgung durchgeführt. Hierbei wurden neben der Verweildauer und den Gesamtkosten des Falls auch einzelne Kostenkategorien wie Personal- und Sachkosten erfasst. Um einen Kostenvergleich von MRSA-positiven und -negativen Patienten zu ermöglichen, wurde ein Matching-Verfahren durchgeführt.
Ergebnisse Insgesamt wurden 107 Fälle betrachtet, wovon bei 27 Fällen ein positiver MRSA-Befund vorlag. Bei Patienten mit positivem Befund konnte eine höhere durchschnittliche Verweildauer (16,93 vs. 15,05 Tage) und höhere durchschnittliche Gesamtkosten (6 601,32 vs. 5 984,78 €) des Falls beobachtet werden. Die beobachteten Unterschiede bei der Verweildauer zwischen Patienten mit positivem und negativem MRSA-Befund waren dabei jedoch nicht statistisch signifikant. Bei MRSA-Patienten konnten signifikant höhere Personalkosten des Pflegedienstes pro Tag in der Fallgruppe der Patienten mit unterdurchschnittlich hohen Gesamtkosten gezeigt werden. Diese lagen bei den MRSA-Patienten bei 97,18 € bzw. bei Nicht-MRSA-Patienten bei 80,44 €. Gegenläufige Tendenzen zeigten sich für die Personalkosten des ärztlichen Dienstes, des medizinisch-technischen Dienstes und den Sach- und Personalkosten der nichtmedizinischen Infrastruktur.
Schlussfolgerung Obwohl wir zeigen konnten, dass MRSA-Patienten auf der geriatrischen Station eine längere Verweildauer sowie höhere Gesamtkosten aufweisen, ergaben sich keine statistisch signifikanten Unterschiede zwischen MRSA-positiven und -negativen Patienten. Als ein Hauptkostentreiber in der Versorgung von Patienten mit MRSA konnten die Personalkosten des Pflegedienstes pro Tag identifiziert werden. Daher kann ein Ansatzpunkt zur effektiveren und effizienteren Versorgung in einer Analyse der Prozesse in Hinblick auf die Pflege von MRSA-positiven Patienten liegen. Die Versorgung von MRSA-Patienten war auf der betrachteten geriatrischen Station nicht in jeder betrachteten Kostenkategorie zwingend mit höheren Kosten im Vergleich zu Nicht-MRSA Patienten verbunden.
Morbus Castleman – eine harmlose Differenzialdiagnose einer Lymphadenitis colli? – Eine Fallserie
Authors: Riepl Ricarda , Hoffmann Thomas , Greve Jens 
Published: May 2017

Zusammenfassung
Der sehr seltene Morbus Castleman kann als potentiell schwerwiegende lymphoproliferative Erkrankung in Form einer zervikalen Lymphadenopathie manifest werden. Dem HNO-Arzt kommt dann eine entscheidende Rolle in der Diagnostik und Therapie zu. Ziel dieser Arbeit ist es, anhand einer Fallserie die Symptomatik, den Krankheitsverlauf bis zur Diagnosestellung und Nachsorge vor dem Hintergrund bestehender Evidenz zu beleuchten.
Eingeschlossen wurden Patienten, bei denen in den Jahren 2011–2015 die Erstdiagnose eines Morbus Castleman in der HNO-Klinik der Universität Ulm gestellt wurde. Evaluiert wurden u. a. die Dauer der bestehenden Symptome sowie die diagnostischen und therapeutischen Maßnahmen.
Gefunden wurden 5 Patienten (3 männlich, 2 weiblich) im Alter zwischen 15 und 43 Jahren. Die Dauer der wenig ausgeprägten Symptome war inkongruent und lag zwischen 14 Tagen und 14 Jahren. Bei allen Patienten konnte nach diagnostischer Exstirpation der Nachweis der hyalin-vaskulären Variante eines Morbus Castleman erbracht werden. In einem der 5 Fälle lag ein multizentrischer Typ mit zusätzlichem axillärem Befall vor, die anderen Fälle waren monozentrisch. Die diagnostische Exstirpation war in allen Fällen immer zugleich auch suffiziente Therapie ohne zusätzliche medikamentöse Adjuvanz. Zum Zeitpunkt der Veröffentlichung befinden sich alle Patienten in Remission (medianes Follow up=27 Monate).
Dem HNO-Arzt begegnet der Morbus Castleman zumeist als therapieresistente und längerfristig bestehende zervikale Lymphadenopathie mit wenig ausgeprägter Begleitsymptomatik und meist fehlenden laborchemischen Auffälligkeiten. Aufgrund der potentiell ungünstigen Verläufe ist eine zügige diagnostische Lymphknotenexstirpation in Vollnarkose indiziert, welche in den meisten Fällen gleichzeitig die suffiziente Therapie darstellt.
Effects of Synchronous Whole Body Vibration Training on a Soft, Unstable Surface in Athletes with Chronic Ankle Instability
Authors: Sierra-Guzmán Rafael , Jiménez Jose , Ramírez Carlos , Esteban Paula , Abián-Vicén Javier 
Published: May 2017

AbstractThe aim of this study was to evaluate the effects of a 6-week WBV training program, performed on a soft, unstable surface, on peak torque, reaction time and the electrical activity of ankle muscles in recreational athletes with chronic ankle instability (CAI). 50 recreational athletes with self-reported unilateral CAI were randomly assigned to a vibration group (VIB), non-vibration group (N-VIB) or control group. The VIB and N-VIB groups performed unilateral balance training on the unstable ankle on a BOSU® Balance Trainer 3 times weekly for 6 weeks. The VIB group trained on a vibration platform, and the N-VIB group trained on the floor. Muscle reaction times and electrical activity of the peroneus brevis (PB), peroneus longus (PL) and tibialis anterior (TA) muscles were assessed in response to sudden inversion, isokinetic peak torque and isokinetic strength ratios of the ankle evertor muscles. After 6 weeks of training, a significant improvement was shown in reaction times of the PB (Pre=60.99±9.17 ms, Post1=54.90±6.99 ms, p=0.003), PL (Pre=61.20±10.72 ms, Post1=55.21±9.04 ms, p=0.007) and TA (Pre=65.31±11.78 ms, Post1=59.07±9.99 ms, p=0.007) muscles in the VIB group, whereas no significant changes were found in the N-VIB group or the control group. There were no significant changes in electrical activity, peak torque and eccentric-concentric ratio for any of the groups after training. In conclusion, a 6-week WBV training program on a soft, unstable surface improves the reaction times of the PB, PL and TA muscles in recreational athletes with CAI.
Trial registration: ClinicalTrials.gov NCT02794194
Ein multimediales Programm zum Trainieren der Schilddrüsensonografie für Medizinstudenten
Authors: Ritter Julia , Wolfram Maximilian , Schuler Stefan , Guntinas-Lichius Orlando 
Published: May 2017

Zusammenfassung
Ärzte in Ausbildung haben häufig bei Berufseintritt aufgrund mangelnder Trainingsangebote im Rahmen ihres Medizinstudiums kaum Erfahrung in der Anwendung und Beurteilung der Sonografie. Daher sollte ein multimediales Programm für das schrittweise Erlernen und das Training der Schilddrüsensonografie entwickelt werden.
Es wurde eine Software zur Gestaltung eines multimedialen Lernprogrammes für ein tragbares Ultraschallsystem genutzt. Die Software erlaubt die Darstellung von Texten und Bildmaterial parallel zur Untersuchung, um eigene Befunde mit Beispielen aus einer Datenbank vergleichen zu können. Das fertiggestellte Tutorial wurde durch 8 Studierende evaluiert und mit einem Tutor-geführten Training verglichen.
Es wurde eine strukturierte, stufenweise Anleitung zur Schilddrüsensonografie mit einer Vielzahl von Beispiel-Sonografien in verschiedenen Schnittbildebenen gestaltet, die der Nutzer parallel am Probanden mit dem Ultraschallgerät nachstellt. Der Informationsgehalt des Tutorials und die Nachvollziehbarkeit der Untersuchungsschritte wurden positiv eingeschätzt. Die Übersichtlichkeit, die Eignung für Anwender mit fehlender Erfahrung und somit auch der Lernerfolg wurden hingegen unterschiedlich bewertet.
Das Tutorial zum Erlernen und zum Training der Schilddrüsensonografie ist ein Instrument zum Selbstlernen und zur Verbesserung der praktischen Ausbildung. In der nächsten Version wird die Untersuchungsanleitung noch detaillierter aufgebaut sein.
Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors
Authors: Trigos Anna S. , Pearson Richard B. , Papenfuss Anthony T. , Goode David L. 
Published: May 2017

Significance
Cancer represents a breakdown of molecular mechanisms evolved by multicellular life to impose constraints on cell growth, resulting in more “primitive” proliferative cellular phenotypes. This suggests interpreting the activity of genes in cancer according to their evolutionary origins may provide insights into common mechanisms driving tumorigenesis. We incorporated phylogenetic and interaction data into expression analysis of seven solid tumors, revealing universal strong preferential expression of genes shared with unicellular species in tumors, alongside widespread disruption of links between unicellular and multicellular components of gene regulatory networks. Considering how the constraints imposed on these networks by evolution were altered in tumors identified molecular processes that could be manipulated for therapeutic benefit in cancer and uncovered several promising drug targets.
Chromosome-level genome assembly and transcriptome of the green algaChromochloris zofingiensisilluminates astaxanthin production
Authors: Roth Melissa S. , Cokus Shawn J. , Gallaher Sean D. , Walter Andreas , Lopez David , Erickson Erika , Endelman Benjamin , Westcott Daniel , Larabell Carolyn A. , Merchant Sabeeha S. , Pellegrini Matteo , Niyogi Krishna K. 
Published: May 2017

SignificanceThe growing human population generates increasing demand for food and energy. Microalgae are a promising source of sustainable bioproducts whose production may not exacerbate worsening environmental problems. The green algaChromochloris zofingiensishas potential as a biofuel feedstock and source of high-value nutraceutical molecules, including the carotenoid astaxanthin. We present a high-quality, chromosome-level assembly of the genome by using a hybrid sequencing approach with independent validation by optical mapping. Our analyses of the genome and transcriptome, in addition to experiments characterizing astaxanthin production, advance understanding of the green lineage and carotenoid production, and enhance prospects for improving commercial production ofC. zofingiensis.
mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells
Authors: Beirowski Bogdan , Wong Keit Men , Babetto Elisabetta , Milbrandt Jeffrey 
Published: May 2017

Significance
The myelination of axons is essential for neuronal wiring and normal nervous system functions. In the peripheral nervous system, Schwann cells (SCs) form myelin sheaths around axons during nerve development. Such myelination is compromised in a number of diseases. Hence, identification and understanding of the key pathways regulating SC development and myelinogenesis are essential for therapeutic progress. Here we uncover two separate roles of the cellular signaling node mTORC1 (mechanistic target of rapamycin complex 1) for regulating the development of SCs and subsequently the growth of myelin sheaths. Moreover, we demonstrate that defective SCs possess a remarkable plasticity to remyelinate axons via mTORC1. Thus, manipulating mTORC1 activity in diseased SCs could be therapeutically beneficial.
Advanced and intermediate EFL learners’ perceptions and practices of autonomous learning
Authors: Jafari Sakineh , Ketabi Saeed , Tavakoli Mansoor 
Published: May 2017

Abstract
This study examined Persian intermediate and advanced EFL learners’ perceptions regarding (a) their own and their teachers’ responsibility in learning language autonomously; (b) their decision making ability in learning language autonomously; and (c) their autonomous learning activities inside and outside the classroom. To this end, a questionnaire designed by Chan, Spratt, and Humphrey (2002) was distributed among 67 intermediate and 65 advanced EFL learners. Statistical analysis of students’ answers showed that overall, advanced learners tended to assume more responsibility for their own learning, to perceive themselves to be highly capable of autonomous learning, and to practice more autonomous learning activities compared to the intermediate learners. In addition, data collected through the interviews with some of the participants suggested that learners’ perceptions were greatly affected by their previous educational experiences. Since intermediate learners were not largely engaged in making decisions related to educational materials and activities used in their classrooms, they considered themselves as less responsible for and consequently less capable of choosing learning materials and activities. The findings of the study, along with the pedagogical implications, are discussed.
The space for strategic manoeuvring in adjudicating a freedom of speech case in the Netherlands
Authors: Jansen Henrike 
Published: May 2017

Abstract
In this article it is shown that the institutional preconditions of the activity type adjudicating a freedom of speech case leave much room for strategic manoeuvring with topical selection. To this end, an analysis is presented of the argumentation of the District Court in a case against the Dutch anti-immigration politician Geert Wilders. In order to show the space for manoeuvring, this argumentation, resulting in acquittal, is compared with the argumentation put forward by the Court of Appeal, which had ordered, after the Public Prosecution Service’s refusal to do so, that Wilders be prosecuted. The analysis shows that the District Court made ample use of the space for manoeuvring provided at the normative level concerning the interpretation of legal rules and case law, and the space provided at the factual level of classifying the contested facts in light of the previously identified meaning of a rule.
Do adult-children dialogical interactions leave space for a full development of argumentation?
Authors: Greco Sara , Mehmeti Teuta , Perret-Clermont Anne-Nelly 
Published: May 2017

AbstractThis paper sets out to analyse a case study of adult-children interaction in an educational context from a perspective of argumentation. We select a case in which 3 argumentative discussions are opened and we analyse them with the aim of understanding whether they are fully developed from a point of view of argumentation; or whether they are cut short and why. Our focus is not on the children’s individual productions but on the process of interaction. We assume the pragma-dialectical model of argumentation and the AMT as a theoretical framework. Our findings show that none of the discussions opened gets to a concluding stage, either because the teacher shifts the discussion on a different issue, or because the opening stage is not clear, or because the argumentation stage is not adequately developed. These findings contribute to conceptual clarification about how to interpret the role of a teacher.
Competition and conflict between communicative norms
Authors: Hoppmann Michael 
Published: May 2017

AbstractWhen engaging with each other, discussants navigate a complex set of communicative norms that aim at very different goals. Within argumentation theory naturally the most studied set of norms are those aiming at reasonableness, of which I take the pragma-dialectical rule set to be a representative example. They are however far from the only norms that guide communicative behavior. This paper offers an analysis of the areas of intersection and potential conflict of reasonableness (as understood by pragma-dialectics) with other communicative norms in general and rules of politeness (as presented by Geoffrey Leech) in particular.
The case for alveolar fricative rhotics with evidence from Nusu
Authors: Ikeda Elissa , Lew Sigrid 
Published: May 2017

AbstractCross-linguistically, fricatives are the rarest types of rhotics, found in a few African and European languages (Ladefoged & Maddieson 1996) and as allophones in some Romance languages (Jesus & Shadle 2005;Recasens 2002;Bradley 2006;Colantoni 2006). Acoustic data from Nusu, phonotactic reasoning, and a cognate comparison demonstrate the presence of alveolar fricative rhotics in Tibeto-Burman. The Nusu rhotic appears in syllable-initial position as the first or second consonant and can be realized as alveolar approximants [ɹ] or [ɹʲ], non-sibilant voiced and voiceless fricatives [ɹ̝, ɹ̥], as well as voiced sibilant [ʐ]. In other studies on Nusu, these fricative rhotics have sometimes been reported as retroflex voiced sibilants (Sun & Lu 1986;Fu 1991), but intra-speaker and cross-variety comparison point to classification as rhotics. Evidence from other Tibeto-Burman languages suggests that alveolar fricative rhotics are not limited to Nusu. Together these data challenge the tradition of generally interpreting alveolar fricatives as sibilants.
Kiranti double negation
Authors: van der Auwera Johan , Vossen Frens 
Published: May 2017

AbstractIt is shown how Kiranti languages often express a semantically single clausal negation of a declarative verbal main clause with two clausal negators. We conjecture that the second negator has its origin in a copula and that the reinterpretation and integration of the copula into a negative construction follows the scenario known as a “Jespersen Cycle”.
On the origin of Gamale Kham labial-palatal approximants
Authors: Wilde Christopher P. 
Published: May 2017

AbstractThe development of the Gamale Kham labial-palatal approximants /ɥ/ and /ɥ̊/ has previously been attributed to the loss of the Proto-Kham initial *p- or the coda *-p. The vowels /i/ and /e/ which occurred in the adjacent syllable nucleus were rounded, resulting in the front rounded vowels /y/ and /ø/. Following this development, /w/ and /j/ merged to /ɥ/ in Gamale and Eastern Parbate Kham (Watters 2002;2004;2005). This study evaluates this theory and suggests two alternative explanations: that Proto-Kham may have had either two front rounded vowels *y and *ø, or a *ɥ phoneme. In the second case, the work refers to a possible correspondence between a Proto-Kham *ɥ and the Proto-Tibeto-Burman complex *jw.
Factors Influencing Nest Survival in Florida Bass
Authors: Slagle Z. , Allen M. S. , Shaw S. L. 
Published: May 2017

AbstractAngling nesting Florida Bass Micropterus salmoides floridanus may influence the survival of the brood and could negatively affect bass populations. Our objectives were to estimate daily nest survival for Florida Bass and to examine factors that influence nest survival to the swim‐up fry stage. Snorkelers examined a total of 259 nests in a small, mesotrophic lake in north‐central Florida from 2010 to 2012. We compared nest survival rates with accumulated degree‐days, largest temperature drop following nest discovery, nest score, presence of a guarding male bass, and size of the guarding male. The most important factor in determining nest survival was the presence of a male bass. However, guarding male fish were only observed on 66% of active nests despite multiple visits to each nest, indicating a lower tendency to remain with the brood than has been reported in other Micropterus species. Florida Bass have displayed lower nest guarding behaviors in other studies; a prolonged spawning season and the presence of top predators in southern bass populations may influence decreased nest fidelity and nest guarding behavior. Individual nesting attempts may be less important for successful Florida Bass recruitment.Received September 28, 2016; accepted February 28, 2017 Published online May 12, 2017
Purification and characterization of hemolysin from periodontopathogenic bacterium Eikenella corrodens strain 1073
Authors: Jasin Mansur Fariha , Takahara Sari , Yamamoto Mihoko , Shimatani Masafumi , Minnatul Karim Mohammad , Noiri Yuichiro , Ebisu Shigeyuki , Azakami Hiroyuki 
Published: May 2017

Abstract
Eikenella corrodens 1073 was found to show hemolytic activity when grown on sheep blood agar. A high and dose-dependent hemolytic activity was detected in the cell envelope fraction, which was further purified by ion-exchange and gel-filtration chromatography. Consequently, a 65-kDa protein with hemolytic activity was obtained, suggesting that this protein might be a hemolysin. Its N-terminal amino acid sequence was nearly identical to that of X-prolyl aminopeptidase from E. corrodens ATCC 23834. To confirm that X-prolyl aminopeptidase functions as a hemolytic factor, we expressed the hlyA gene, encoding X-prolyl aminopeptidase, in Escherichia coli. After induction with isopropyl β-D-1-thiogalactopyranoside, a protein of about 65 kDa was purified on a Ni column, and its hemolytic activity was confirmed. Meanwhile, a strain with a disrupted hlyA gene, which was constructed by homologous recombination, did not show any hemolytic activity. These results suggested that X-prolyl aminopeptidase might function as a hemolysin in E. corrodens.
Final report on the EURAMET.M.FF-K4.2.2014 volume comparison at 100 μL—calibration of micropipettes
Authors: Batista Elsa , Matus Michael , Metaxiotou Zoe , Tudor Maria , Lenard Elzbieta , Buker Oliver , Wennergren Per , Piluri Erinda , Miteva Mariana , Vicarova Martina , Vospĕlová Alena , Turnsek Urska , Micic Ljiljana , Grue Lise-Lote , Mihailovic Mirjana , Sarevska Anastazija 
Published: May 2017

During the EURAMET TC-F meeting of 2014 and following the finalization of CCM.FF-K4.2.2011 comparison, it was agreed to start a Regional Key Comparison (KC) on volume measurements using two 100 μL micropipettes (piston pipettes) allowing the participating laboratories to assess the agreement of their results and uncertainties.
Two 100 μL micropipettes were tested by 15 participants. One participant was not a member or associate member of the BIPM and was be removed from this report. The comparison started in July 2015 and ended in March 2016. The Volume and Flow Laboratory of the Portuguese Institute for Quality (IPQ) was the pilot laboratory and performed the initial and final measurements of the micropipettes. The micropipettes showed a stable volume during the whole comparison, which was confirmed by the results from the pilot laboratory.
The original results of all participant NMIs were corrected to the standard atmospheric pressure in order to compare results under the same calibration conditions, and the contribution of the 'process-related handling contribution' was added to the uncertainty budget of each participant.
In general the declared CMCs are in accordance with the KCDB. For the micropipette 354828Z, two laboratories had inconsistent results. For micropipette 354853Z, three laboratories had inconsistent results.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
The Effects of Tomato Suspension Agreements on Market Price Dynamics and Farm Revenue
Authors: Wu Feng , Guan Zhengfei , Suh Dong Hee 
Published: May 2017

AbstractSince 1996 there have been several suspension agreements between the United States and Mexico that set reference prices for imported Mexican tomatoes. The 2013 suspension agreement raised the reference prices of Mexican tomatoes by 43%. This study conducts an econometric analysis to examine the effects of reference prices on the dynamics of tomato price and farm revenue. Findings indicate that the suspension agreements have resulted in significant adjustments in the U.S. and Mexican tomato prices, and that the two prices are now more interdependent under the 2013 agreement. Although the 2013 suspension agreement has boosted the prices of U.S. tomatoes, simulation analysis shows that the Mexican industry reaps most of the benefits from increased prices under the 2013 suspension agreement. The findings in this study could inform future trade negotiations.