bluuebunny/crossref_metadata_2025_split huggingface dataset:
Periostin Upregulates Wnt/β-Catenin Signaling to Promote the
Osteogenesis of CTLA4-Modified Human Bone
Marrow-Mesenchymal Stem Cells
Authors: Zhang Fei , Luo Keyu , Rong Zhigang , Wang Zhengdong , Luo Fei , Zhang Zehua , Sun Dong , Dong Shiwu , Xu Jianzhong , Dai Fei 
Published: January 2017

AbstractThe enhanced osteogenesis of mesenchymal stem cells (MSCs) modified by
expression of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) has been shown in
previous studies, but the mechanism remains unknown. Here we found that the bone
repair effect of CTLA4-modified MSCs in
demineralized bone matrix (DBM) in a rabbit radius defect model was significantly
better than that observed for unmodified MSCs in DBM or DBM alone, and the periostin
(POSTN) expression in CTLA4-modified MSCs was
significantly higher than that in unmodified MSCs both in
vivo and in vitro. In addition, we
also found that treatment of CTLA4-modified MSCs
with soluble POSTN could inhibit the glycogen synthase kinase-3β activity and
increase β-catenin expression through up-regulation of lipoprotein-related protein-6
phosphorylation to promote osteogenic differentiation, but blocking of integrin
αvβ3, a receptor of POSTN, could suppress these effects. Our data demonstrated that
POSTN expressed in response to CTLA4 can promote the osteogenesis of
xenotransplanted MSCs through interaction with Wnt/β-catenin pathway.
Differentiation of Club Cells to Alveolar Epithelial Cells In Vitro
Authors: Zheng Dahai , Soh Boon-Seng , Yin Lu , Hu Guangan , Chen Qingfeng , Choi Hyungwon , Han Jongyoon , Chow Vincent T. K. , Chen Jianzhu 
Published: January 2017

AbstractClub cells are known to function as regional progenitor cells to repair the bronchiolar epithelium in response to lung damage. By lineage tracing in mice, we have shown recently that club cells also give rise to alveolar type 2 cells (AT2s) and alveolar type 1 cells (AT1s) during the repair of the damaged alveolar epithelium. Here, we show that when highly purified, anatomically and phenotypically confirmed club cells are seeded in 3-dimensional culture either in bulk or individually, they proliferate and differentiate into both AT2- and AT1-like cells and form alveolar-like structures. This differentiation was further confirmed by transcriptomic analysis of freshly isolated club cells and their cultured progeny. Freshly isolated club cells express Sca-1 and integrin α6, markers commonly used to characterize lung stem/progenitor cells. Together, current study for the first time isolated highly purified club cells for in vitro study and demonstrated club cells’ capacity to differentiate into alveolar epithelial cells at the single-cell level.
Control of switched reluctance motor by current profiling under normal and open phase operating condition
Authors: Dúbravka Peter , Rafajdus Pavol , Makyš Pavol , Szabó Loránd 
Published: January 2017

This study is focused on a new approach of current profile computation to minimise switched reluctance motor (SRM) torque ripple both in healthy and one open phase fault condition. The analysis of static parameters by means of finite element method is carried out and it is verified by measurements. The mathematical model of SRM is described to simulate all transients. The new current profiling method is applied and tested for normal and faulty operation of a real SRM. The torque ripple is measured at a 10 kHz switching frequency. Lower torque ripple is obtained when compared with standard control methods, both under normal and open phase conditions. The simulations of diverse dynamic states are carried out and compared with experimental results.
Destination management and visitor management: non-convergent literatures but complementary activities and issues.
Authors: Pearce D. G. 
Published: January 2017

Abstract

This chapter systematically explores the relationship between destination management and visitor management (VM) by investigating and comparing the goals, policies and implementation activities associated with each of them. By bridging the two streams of literature, this chapter thus lays a foundation for the appreciation of VM research at the different levels of a destination in this book.
The relevance of visitors' national park affinity for effective visitor management in protected areas.
Authors: Bayer J. , Fehringer A. , Lehar G. , Jurgeit F. , Leitner T. 
Published: January 2017

Abstract

This chapter introduces the concept of visitor affinity to the visitor management (VM) literature. It illustrates the basic possibilities and limits of segmentation by visitor affinity, within the framework of visitor monitoring in protected areas. For this purpose, different methodological procedures are identified and discussed in order to allow a better comparison between protected areas. Hereupon, guiding strategies for a target group-oriented VM are formulated. The Hohe Tauern National Park, Austria, is used as a case study for empirical research.
Using heritage interpretation to manage film-induced tourism at heritage visitor attractions.
Authors: Bakiewicz J. , Leask A. , Barron P. , Rakic T. 
Published: January 2017

Abstract

This chapter shows the potential value of heritage interpretation in the context of addressing a range of potential visitor management (VM) challenges at heritage visitor attractions (HVAs) where film-induced tourism has occurred. Its empirical discussions explore management challenges at one such HVA, Alnwick Castle in the UK, and pay particular attention to (post-film exposure) visitors' expectations and the influence these have had on heritage interpretation at the site. The chapter argues that, in the context of film-induced tourism at HVAs, heritage interpretation can be a particularly valuable VM tool and one which is increasingly considered to be an essential part of the overall quality of visitors' experiences.
Islam - spiritual journey in Islam: the Qur'anic Cognitive Model.
Authors: Elhadary T. 
Published: January 2017

Abstract

This chapter has two objectives. First, to acquaint the reader with certain Islamic matters which they should grasp before embarking on an Islamic-related religious journey, or more specifically visiting Muslim religious historical places, if they wish to reach a more than superficial understanding of the Qur'an. Second, the chapter illuminates the major tenets of faith referred to in the Qur'an. Thus, the chapter attempts to clarify the concept of pilgrimage in Islam and to address questions about Islam that commonly arise in the mind of the non-Muslim tourist (and/or pilgrim). These notions are drawn out and explored by utilizing the Qur'anic Cognitive Model (or QCM), thus presenting the basic claims of the Qur'an and thereby minimizing the degree of deviation from mainstream Islam.
A defence of anti-criterialism
Authors: Langford Simon 
Published: January 2017

AbstractAccording to philosophical orthodoxy, there are informative criteria of identity over time. Anti-criterialism rejects this orthodoxy and claims that there are no such criteria. This paper examines anti-criterialism in the light of recent attacks on the thesis by Matt Duncan, Sydney Shoemaker and Dean Zimmerman. It is argued that those attacks are not successful. Along the way, a novel strategy to defend anti-criterialism against the critics’ most challenging objection is developed. Under-appreciated difficulties for criterialism are also raised which, I claim, there is no obvious way to solve. It is concluded that anti-criterialism may be a much stronger rival to criterialism than is often supposed.
Cell proliferation depends on the direct binding between PKM2 and AKAP-Lbc
Authors: Chen Xinping , Carnegie Graeme K. 
Published: January 2017

AbstractThe M2 form of the glycolytic enzyme pyruvate kinase (PKM2) has generated much interest recently due to its important role in tumor metabolism. A yeast two-hybrid screen carried out by the Alliance for Cell Signaling suggests that PKM2 interacts with A-Kinase Anchoring Protein (AKAP)-Lbc.AKAP-Lbc (also known as AKAP13) is a scaffold protein that integrates signaling through multiple enzymes including protein kinases A and D and the small G protein Rho. AKAP-Lbc was originally identified in leukemic blast cells, and multiple reports implicate AKAP-Lbc in breast, prostate and thyroid cancers, however the role of AKAP-Lbc in cancer biology is not understood.Co-immunoprecipitation, pulldown and Bimolecular Fluorescence Complementation (BiFC) data indicate that PKM2 interacts with AKAP-Lbc. Mapping experiments indicate that PKM2 directly interacts with amino acid residues 1923-2817 of AKAP-Lbc. By disrupting the interaction between the two proteins with the expression of the AKAP-Lbc fragments, our data suggest that the binding between PKM2 and PKA plays a critical role in cell proliferation. The work indicates that the binding between AKAP-Lbc and PKM2 may be an important target to treat some cancers by reducing the cell proliferation.
Contemporary evolution of a Lepidopteran species,Heliothis virescens, in response to modern agricultural practices
Authors: Fritz Megan L , DeYonke Alexandra M , Papanicolaou Alexie , Micinski Stephen , Westbrook John , Gould Fred 
Published: January 2017

AbstractAdaptation to human-induced environmental change has the potential to profoundly influence the genomic architecture of affected species. This is particularly true in agricultural ecosystems, where anthropogenic selection pressure is strong.Heliothis virescensfeeds on cotton in its larval stages and US populations have been declining since the widespread planting of transgenic cotton, which endogenously express proteins derivedBacillus thuringiensis(Bt). No physiological adaptation to Bt toxin has been found in the field, so adaptation to this altered environment could involve: 1) shifts in host plant selection mechanisms to avoid cotton, 2) changes in detoxification mechanisms required for cotton-feeding versus feeding on other host plants, or 3) loss of resistance to previously used management practices including insecticides. Here we begin to address the question of whether such changes occurred inH. virescenspopulations between the years 1997 and 2012. As part of our study, we produced anH. virescensgenome assembly and used this in concert with a ddRAD-seq enabled genome scan to identify loci with significant allele frequency changes over the 15 year period after Bt crops became widespread in the agricultural landscape. Confirmation that a known genetic change at a previously describedH. virescenstarget of selection was detectable in our genome scan increased our confidence in this methodology. We quantified the strength of selection required to elicit the observed allele frequency changes at loci under selection. Potential contributions of genes near the loci under selection to adaptive phenotypes in theH. virescenscotton system are discussed.
The mitochondrial genomes of the acoelomorph wormsParatomella rubraandIsodiametra pulchra
Authors: Robertson Helen E , Lapraz François , Egger Bernhard , Telford Maximilian J , Schiffer Philipp H. 
Published: January 2017

AbstractAcoels are small, ubiquitous, but understudied, marine worms with a very simple body plan. Their internal phylogeny is still in parts unresolved, and the position of their proposed phylum Xenacoelomorpha (Xenoturbella+Acoela) is still debated.Here we describe mitochondrial genome sequences from two acoel species:Paratomella rubraandIsodiametra pulchra. The 14,954 nucleotide-longP. rubrasequence is typical for metazoans in size and gene content. The largerI. pulchramitochondrial genome contains both ribosomal genes, 21 tRNAs, but only 11 protein-coding genes. We find evidence suggesting a duplicated sequence in theI. pulchramitochondrial genome.Mitochondrial sequences for bothP. rubraandI. pulchrahave a unique genome organisation in comparison to other published metazoan mitochondrial genomes. We found a large degree of protein-coding gene and tRNA overlap inP. rubra, with little non-coding sequence making the genome compact. Conversely, theI. pulchramitochondrial genome has many long non-coding sequences between genes, likely driving the genome size expansion. Phylogenetic trees inferred from concatenated alignments of mitochondrial genes grouped the fast-evolving Acoela and Tunicata, almost certainly due to the systematic error of long branch attraction: a reconstruction artefact that is probably compounded by the fast substitution rate of mitochondrial genes in this taxon.
Assembly line design considering line balancing and part feeding
Authors: Nourmohammadi Amir , Eskandari Hamidreza 
Published: January 2017

Purpose
This paper aims to optimize the configuration of assembly lines (ALs) considering the two long-term decision problems within the line balancing and part feeding (PF) contexts, when the supermarket concept is applied in PF.

Design/methodology/approach
To this purpose, a bi-level mathematical model is proposed to deal with the assembly line balancing problem (ALBP) and supermarket location problem (SLP) during the strategic decision-making phase of ALs’ configuration. The proposed model is applied on the known test problems taken from the ALBP literature to verify its performance.

Findings
The computational results verify that when the proposed structure is applied, the resulting AL configurations are optimized from both ALBP and SLP considerations in terms of the number of stations and line efficiency as well as supermarket transportation and installation costs.

Originality/value
No study has yet dealt with the long-term decision problem of configuring ALs considering both ALBP and SLP. Also, this study validates the effect of the ALBP on the SLP solutions as two long-term interrelated decision problems.
Field oriented predictive control strategy for induction machine drives
Authors: Qi Xin , Wu Lin , Zhou Xiaomin , Ma Xianghua 
Published: January 2017

Purpose
This study aims to drive the induction machine system with a low switching frequency.

Design/methodology/approach
An unconventional inverter control strategy – field-oriented predictive control (FOPC) – is presented. The strategy limits current distortion by setting a boundary circle. The voltage vector, which could keep current trajectories in boundary, is selected to obtain a low switching frequency.

Findings
A dual simulation step technique is developed to investigate the influence of sampling frequency on current distortion control and switching frequency. Current control distortion can be improved, i.e. reduced, by increasing the sampling frequency; however, the switching frequency will also increase. Such a law is discovered by the dual simulation step technique and finally verified by experiments.

Originality/value
A new predictive control method, FOPC, is derived from the rotor filed coordinate machine model and presented in this paper. FOPC circumvents derivative calculations, and thus avoids high-frequency noise amplification.
Humans’ relationship to nature – framing sustainable marketing
Authors: Löbler Helge 
Published: January 2017

Purpose
Although humans are part of nature, the relationship between humans and nature is not well understood, neither in sustainable marketing nor in relationship marketing. Nature is damaged by humans, and a lot of natural resources coming from nature are taken for granted. The services provided by nature are also often taken for granted. However, humans cannot live without these services, but nature can probably survive without humans, especially man-made (artificial) services. The paper aims to offer a frame that allows aligning marketers and academics’ understanding of service with that of sustainability for sustainable marketing.

Design/methodology/approach
A literature review of different literature streams, biological, ecological and service literature shows that service is a much broader phenomenon as discussed in the service literature. The paper will show that a fundamental relationship between either humans or humans and nature is service as defined here. Service is understood here as an ongoing process of exchange and change. Service as proposed here is a form of coexistence.

Findings
Service will be defined as an ongoing process of exchange and change (transfer and transformation) of resources. This understanding integrates human and natural service without connecting it only to human intentions, wishes or needs as causation for service. The process of service as conceptualized here is in line with the understanding of sustainability, as it is discussed nowadays. Aligning marketers’ understanding of service with that of sustainability gives a new frame for sustainable marketing.

Research limitations/implications
The work may be understood as a step toward a sustainable marketing by framing sustainable processes from a service perspective. The holistic understanding of sustainable marketing offers new chances not only for further research but also for a better (more sustainable) understanding of day-to-day practices.

Practical implications
If humans understand the fundamental relationship with nature, it can help to act in harmony with nature and not against it to improve sustainable development based on a better understanding of human’s relationship with nature.

Social implications
Mainstream sustainable marketing is sometimes based on a strong anthropocentrism. This paper balances the role of humans toward nature.

Originality/value
It is the first paper in relationship marketing looking at the relationship with nature and uses this view to frame this concept of sustainable marketing.
The importance of CSR in forming customer–company identification and long-term loyalty
Authors: Huang Min-Hsin , Cheng Zhao-Hong , Chen I-Chun 
Published: January 2017

Purpose
Promoting customer–company identification (CCI) has become a crucial relationship marketing strategy for service firms. The purpose of this study is to examine how customers’ perceptions of service quality and corporate social responsibility (CSR) affect CCI over time. More importantly, a comparative analysis is conducted to compare the long-term effectiveness of service quality versus CSR in forming CCI.

Design/methodology/approach
A conceptual framework is developed and then empirically examined using latent growth curve modeling. The study data were collected from restaurant customers in Taiwan in four waves of 213 repeated measures.

Findings
The results of this study show that customers’ perceptions of both service quality and CSR affect CCI. Particularly, the results of this study indicate that compared with service quality, customers’ perceived CSR has a stronger effect in the promotion of CCI over time.

Practical implications
This study offers a new insight for service marketing practitioners who are planning and implementing strategies for enhancing CCI. The findings suggest that relationship investments are more effective over the long term when service firms shift their investment priority over time from achieving high service quality to increasing consumers’ belief in the firm’s commitment to CSR.

Originality/value
Though previous research has explored the various drivers of CCI, longitudinal examinations are surprisingly scarce in this context. Using latent growth curve modeling, this study examines how CCI antecedents influence changes in CCI over time. More importantly, this study reveals that CSR has a stronger long-term impact on CCI than service quality.
From relationship marketing to total relationship marketing and beyond
Authors: Gummesson Evert 
Published: January 2017

Purpose
This paper aims to emphasize the need for generation of more general, abstract and grand theory in marketing by synthesizing relationship marketing and other developments and to address complexity instead of fragmented bits of marketing.

Design/methodology/approach
This study is a discourse based on new theoretical developments, literature and personal reflection.

Findings
Relationships, networks and interaction constitute the core of marketing.

Research limitations/implications
Future focus on theory generation and complexity through case study research and not on fragmented quantitative surveys and hypotheses testing. When complexity is better understood, boil it down to actionable simplicity in the form of mid-range theory.

Practical implications
Research in marketing is there to be used in real life; it is not an academic parlor game. The paper addresses complexity instead of shunning it, search for the core of marketing and offer simplification as mid-range theory (checklists, heuristics, etc.) and with focus on decisions, action and results.

Originality/value
Going from the current fragmented approach of marketing to a holistic and theory-based approach, linking theory with practice.
Role stressors and coping strategies among nurse managers
Authors: Udod Sonia , Cummings Greta G. , Care W. Dean , Jenkins Megan 
Published: January 2017

Purpose
The purpose of this paper is to share preliminary evidence about nurse managers’ (NMs) role stressors and coping strategies in acute health-care facilities in Western Canada.

Design/methodology/approach
A qualitative exploratory inquiry provides deeper insight into NMs’ perceptions of their role stressors, coping strategies and factors and practices in the organizational context that facilitate and hinder their work. A purposeful sample of 17 NMs participated in this study. Data were collected through individual interviews and a focus group interview. Braun and Clarke’s (2006) six phase approach to thematic analysis guided data analysis.

Findings
Evidence demonstrates that individual factors, organizational practices and structures affect NMs stress creating an evolving role with unrealistic expectations, responding to continuous organizational change, a fragmented ability to effectively process decisions because of work overload, shifting organizational priorities and being at risk for stress-related ill health.

Practical implications
These findings have implications for organizational support, intervention programs that enhance leadership approaches, address individual factors and work processes and redesigning the role in consideration of the role stress and work complexity affecting NMs health.

Originality/value
It is anticipated that health-care leaders would find these results concerning and inspire them to take action to support NMs to do meaningful work as a way to retain existing managers and attract front line nurses to positions of leadership.
Responsible leader behavior in health sectors
Authors: Longest Beaufort 
Published: January 2017

Purpose
The purpose of this paper is to expand attention to responsible leader behavior in the world’s health sectors by explaining how this concept applies to health sectors, considering why health sector leaders should behave responsibly, reviewing how they can do so, and asserting potential impact through an applied example.

Design/methodology/approach
This paper is a viewpoint, reflecting conceptualizations rooted in leadership literature which are then specifically applied to health sectors. A definition of responsible leader behavior is affirmed and applied specifically in health sectors. Conceptualizations and viewpoints about practice of responsible leader behavior in health sectors and potential consequences are then discussed and asserted.

Findings
Leadership failures and debacles found in health, but more so in other sectors, have led leadership researchers to offer insights, many of them empirical, into the challenges of leadership especially by more clearly delineating responsible leader behavior.

Practical implications
Much of what has been learned in the research about responsible leader behavior offers pathways for health sector leaders to more fully practice responsible leadership.

Social implications
This paper asserts and provides a supporting example that greater levels of responsible leader behavior in health sectors hold potentially important societal benefits.

Originality/value
This paper is the first to apply emerging conceptualizations and early empirical findings about responsible leader behavior specifically to leaders in health sectors.