bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ordinary Interactions Challenge Proposals That Maternal Verbal Responses Shape Infant Vocal Development
Authors: Fagan Mary K. , Doveikis Kate N. 
Published: October 2017

Purpose
This study tested proposals that maternal verbal responses shape infant vocal development, proposals based in part on evidence that infants modified their vocalizations to match mothers' experimentally manipulated vowel or consonant–vowel responses to most (i.e., 70%–80%) infant vocalizations. We tested the proposal in ordinary rather than experimentally manipulated interactions.

Method
Response-based proposals were tested in a cross-sectional study of 35 infants, ages 4 to 14 months, engaged in everyday interactions in their homes with their mothers using a standard set of toys and picture books.

Results
Mothers responded to 30% of infant vocalizations with vocal behaviors of their own, far fewer than experimentally manipulated response rates. Moreover, mothers produced comparatively few vowel and consonant–vowel models and responded to infants' vowel and consonant–vowel vocalizations in similar numbers. Infants showed little evidence of systematically modifying their vocal forms to match maternal responses in these interactions. Instead, consonant–vowel vocalizations increased significantly with infant age.

Conclusions
Results obtained in ordinary interactions, rather than response manipulation, did not provide substantial support for response-based mechanisms of infant vocal development. Consistent with other research, however, consonant–vowel productions increased with infant age.
Architecture of the Suprahyoid Muscles: A Volumetric Musculoaponeurotic Analysis
Authors: Shaw Stephanie M. , Martino Rosemary , Mahdi Ali , Sawyer Forrest Kip , Mathur Sunita , Hope Andrew , Agur Anne M. 
Published: October 2017

PurposeSuprahyoid muscles play a critical role in swallowing. The arrangement of the fiber bundles and aponeuroses has not been investigated volumetrically, even though muscle architecture is an important determinant of function. Thus, the purpose was to digitize, model in three dimensions, and quantify the architectural parameters of the suprahyoid muscles to determine and compare their relative functional capabilities.MethodFiber bundles and aponeuroses from 11 formalin-embalmed specimens were serially dissected and digitized in situ. Data were reconstructed in three dimensions using Autodesk Maya. Architectural parameters were quantified, and data were compared using independent samplest-tests and analyses of variance.ResultsBased on architecture and attachment sites, suprahyoid muscles were divided into 3 groups: anteromedial, superolateral, and superoposterior. Architectural parameters differed significantly (p< .05) across muscles and across the 3 groups, suggesting differential roles in hyoid movement during swallowing. When activated simultaneously, anteromedial and superoposterior muscle groups could work together to elevate the hyoid.ConclusionsThe results suggest that the suprahyoid muscles can have individualized roles in hyoid excursion during swallowing. Muscle balance may be important for identifying and treating hyolaryngeal dysfunction in patients with dysphagia.
Limb and Flap Salvage in Gustilo IIIC Injuries Treated by Vascular Repair and Emergency Free Flap Transfer
Authors: Papa Giovanni , Ramella Vittorio , Novati Federico , Ahcan Uros , Stocco Chiara , Arnež Zoran 
Published: October 2017

Background Gustilo classification system defines IIIC fractures as open fractures associated with an arterial injury that requires repair. The aim of our study was to analyze the early outcome in terms of limb and flap salvage, early amputation, and early complication rate in patients with Gustilo IIIC open fractures treated in an emergency setup.
Methods We retrospectively reviewed 20 patients with Gustilo IIIC injuries treated by the “fix and flap” principle during the first surgical procedure in the first 24 hours after injury (emergency free flap transfer). All patients underwent surgery with radical debridement, wound irrigation, skeletal stabilization, vascular repair, and immediate free flap coverage.
Results In this study, 18 patients were men (90%) and 2 were women (10%). In all patients, a vascular repair was performed and in 17 cases (85%), the lower limb/foot was avascular and limb salvage was performed. Three patients had one vessels injured (15%) and 17 had two or three vessels injured (85%). In 9 out of 20 (45%), a revision surgery was needed for arterial (10%, 2 patients), arterial–venous (15%, 3 patients), and venous thrombosis (20%, 4 patients), while 4 patients required an early amputation (20%) and 1, a late one (5%). In three patients (15%), a flap loss occurred. Superficial infection occurred in seven cases (35%) and deep infection (osteomyelitis) in one (5%).
Conclusion A single-stage procedure performed in an emergency operating room could lead to an effective outcome with a high rate of limb salvage and satisfying long-term results.
Men’s Involvement in a Parenting Programme to Reduce Child Maltreatment and Gender-Based Violence: Formative Evaluation in Uganda
Authors: Siu Godfrey E. , Wight Daniel , Seeley Janet , Namutebi Carolyn , Sekiwunga Richard , Zalwango Flavia , Kasule Sarah 
Published: October 2017

AbstractParenting programmes involving fathers can reduce child maltreatment and gender-based violence. However, most parenting programmes find it difficult to recruit fathers. We piloted a 21 session parenting intervention, ‘Parenting for Respectability’, with fathers and mothers near Kampala, Uganda. Sixty-one fathers and 83 mothers were recruited initially and 52 fathers and 76 mothers retained to the end. We interviewed with 24 fathers and 16 mothers. Data were analysed thematically. Success in involving fathers was probably due to (a) the first 10 sessions being father-only, allowing them to share experiences before participating in mixed-sex sessions; (b) exploiting men’s pre-existing motivation to improve their children’s behaviour, thereby enhancing family respectability; and (c) the interactive, participatory delivery. Mixed sessions enabled couples to clarify conflicting perspectives regarding spousal relationships and gendered norms. However, men experienced social pressure to conform to conventional masculinity, suggesting the need to instil intervention values at community level.
Prairie strips improve biodiversity and the delivery of multiple ecosystem services from corn–soybean croplands
Authors: Schulte Lisa A. , Niemi Jarad , Helmers Matthew J. , Liebman Matt , Arbuckle J. Gordon , James David E. , Kolka Randall K. , O’Neal Matthew E. , Tomer Mark D. , Tyndall John C. , Asbjornsen Heidi , Drobney Pauline , Neal Jeri , Van Ryswyk Gary , Witte Chris 
Published: October 2017

Significance
Prairie strips are a new conservation technology designed to alleviate biodiversity loss and environmental damage associated with row-crop agriculture. Results from a multiyear, catchment-scale experiment comparing corn and soybean fields with and without prairie vegetation indicated prairie strips raised pollinator and bird abundance, decreased water runoff, and increased soil and nutrient retention. These benefits accrued at levels disproportionately greater than the land area occupied by prairie strips. Social surveys revealed demand among both farm and nonfarm populations for the outcomes prairie strips produced. We estimated prairie strips could be used to improve biodiversity and ecosystem services across 3.9 million ha of cropland in Iowa and a large portion of the 69 million ha under similar management in the United States.
Stress attenuates the flexible updating of aversive value
Authors: Raio Candace M. , Hartley Catherine A. , Orederu Temidayo A. , Li Jian , Phelps Elizabeth A. 
Published: October 2017

Significance
A primary goal of translational affective science is to gain a more mechanistic understanding of how stress renders individuals vulnerable to maladaptive threat responses that lead to affective psychopathology. Here, we examined how exposure to acute stress influences the flexible modulation of threat response using reversal learning, a canonical assay of behavioral flexibility. We found that stress exposure led to marked deficits in updating affective responses to shifting sources of threat and that this deficit emerged from a failure to adjust learning rates to accurately reflect new patterns of aversive reinforcement. Our findings point to stress exposure as playing a causal role in reducing affective flexibility through selective learning mechanisms and have implications for healthy and clinical populations alike.
CTCF prevents genomic instability by promoting homologous recombination-directed DNA double-strand break repair
Authors: Lang Fengchao , Li Xin , Zheng Wenhai , Li Zhuoran , Lu Danfeng , Chen Guijun , Gong Daohua , Yang Liping , Fu Jinlin , Shi Peng , Zhou Jumin 
Published: October 2017

Significance
CTCF interacts with the genome through thousands of sites and organizes the genome into topological domains, but whether CTCF has direct functions in the maintenance of genome stability is not known. Here, we report that CTCF depletion increases chromosomal instability and activates the DNA damage response. We show that CTCF is recruited to sites of DNA lesions in a process that depends on DNA damage signaling and the DNA-binding domain of CTCF, and that CTCF participates in homologous recombination repair of DNA double-strand breaks by interacting with Rad51 and promoting Rad51 repair foci formation. Thus, CTCF maintains genome stability by participating in DNA repair, highlighting a potential link between genome organization and genome stability.
CRISPR-Cas9–based treatment of myocilin-associated glaucoma
Authors: Jain Ankur , Zode Gulab , Kasetti Ramesh B. , Ran Fei A. , Yan Winston , Sharma Tasneem P. , Bugge Kevin , Searby Charles C. , Fingert John H. , Zhang Feng , Clark Abbot F. , Sheffield Val C. 
Published: October 2017

Significance
A mutation in myocilin is the most common known genetic cause of primary open-angle glaucoma (POAG). These mutations, which are dominant in nature, affect trabecular meshwork (TM) health and/or function and cause elevated intraocular pressure. Using in vitro human trabecular meshwork cells, an in vivo mouse model, and ex vivo human eyes, our study demonstrates the potential of clustered regularly interspaced short palindromic repeats (CRISPR)-mediated genome editing in human myocilin-associated POAG. By disrupting the mutant myocilin gene and its function using CRISPR-Cas9, we were able to reduce associated endoplasmic reticulum stress, lower intraocular pressure, and prevent further glaucomatous damage in mouse eyes. We also show the feasibility of using the CRISPR-Cas9 system in cultured human eyes.
Principles for computational design of binding antibodies
Authors: Baran Dror , Pszolla M. Gabriele , Lapidoth Gideon D. , Norn Christoffer , Dym Orly , Unger Tamar , Albeck Shira , Tyka Michael D. , Fleishman Sarel J. 
Published: October 2017

Significance
Antibodies are the most versatile class of binding molecule known, and have numerous applications in biomedicine. Computational design of antibodies, however, poses unusual difficulties relative to previously designed proteins, as antibodies comprise multiple nonideal features, such as long and unstructured loops and buried charges and polar interaction networks. We developed an algorithm that uses information on backbone conformations and sequence-conservation patterns observed in natural antibodies to design new antibody binders. Designed antibodies were very different in sequence from natural ones, but had similarly desirable properties of affinity and stability, and molecular structures showed high accuracy relative to the design models. The design principles we implemented can be used to design other functional folds, including many enzyme classes.
Framework for gradual progression of cell ontogeny in the
Arabidopsis
root meristem
Authors: Wendrich Jos R. , Möller Barbara K. , Li Song , Saiga Shunsuke , Sozzani Rosangela , Benfey Philip N. , De Rybel Bert , Weijers Dolf 
Published: October 2017

Significance
Plants have the ability to live and grow for many thousands of years due to the activity of groups of cells called meristems. Meristems contain stem cells that can survive the entire life of the plant and ensure the continuous supply of new cells. Stem cells are thought to be qualitatively different compared with their neighboring daughter cells. Here we show that in the case of the proximal root meristem, there does not seem to be such an on-off type of organization. We show that the majority of transcripts, together with other cellular properties, gradually transition from stem cell activity to differentiation, by opposing gradients. This impacts our understanding of meristem organization and will determine the direction of future research.
Katabatic winds diminish precipitation contribution to the Antarctic ice mass balance
Authors: Grazioli Jacopo , Madeleine Jean-Baptiste , Gallée Hubert , Forbes Richard M. , Genthon Christophe , Krinner Gerhard , Berne Alexis 
Published: October 2017

Significance
Precipitation over Antarctica remains largely unknown, despite its crucial role in the surface mass balance of the Antarctic ice sheet. Using unprecedented observations covering an entire year, this work describes a previously unknown mechanism that leads to the sublimation of a large fraction of snowfall in the lower atmosphere, resulting from the interaction of precipitation and katabatic winds. Snowfall sublimation in the atmosphere, caused by katabatic winds, is in the order of 35% in the margins of East Antarctica. This process critically affects the interpretation of satellite-based remote sensing observations close to the ground and suggests that snowfall sublimation in a warming climate may counterbalance the expected increase of precipitation.
Universal poroelastic mechanism for hydraulic signals in biomimetic and natural branches
Authors: Louf J.-F. , Guéna G. , Badel E. , Forterre Y. 
Published: October 2017

SignificancePlants are sessile organisms without nerves. As such, they have developed specific mechanisms to carry information rapidly throughout their body in response to mechanical stimuli. Recently, it has been suggested that the first stage of this long-distance signaling could be the propagation of hydraulic signals induced by the mechanical deformation of the plant tissue (bending), but the physical origin of this hydromechanical coupling remains a conundrum. Here, we address this issue by combining experiments on natural tree branches and soft biomimetic beams with modeling. We reveal a generic nonlinear mechanism responsible for the generation of hydraulic pulses induced by bending in poroelastic branches. Our study gives a physical basis for long-distance communication in plants based on fast hydraulic signals.
A protean clamp guides membrane targeting of tail-anchored proteins
Authors: Chio Un Seng , Chung SangYoon , Weiss Shimon , Shan Shu-ou 
Published: October 2017

Significance
To maintain cellular organization, many chaperones and targeting factors escort nascent proteins to membrane destinations. It was generally thought that substrate proteins preferably bind conformationally closed chaperones. Here, we used single-molecule spectroscopy to study the conformation and dynamics of the ATPase guided entry of tail-anchored protein 3 (Get3), which delivers an essential class of tail-anchored proteins (TAs) to the endoplasmic reticulum. Contrary to previous models, TA-bound Get3 rapidly fluctuates between open and closed conformations, forming a “protean clamp” that stably traps substrates. Biochemical data showed that this dynamic opening primes Get3 for targeting of TAs to membrane receptor sites. Analogous protean traps may operate in other chaperones, targeting factors, and transporters, providing a dual mechanism to both stably retain substrates and vectorially drive cellular processes.
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
Authors: Dang Bobo , Wu Haifan , Mulligan Vikram Khipple , Mravic Marco , Wu Yibing , Lemmin Thomas , Ford Alexander , Silva Daniel-Adriano , Baker David , DeGrado William F. 
Published: October 2017

Significance
The incorporation of a small organic molecule into a protein core opens the door to create previously inaccessible three-dimensional structures. When combined with modern computational methods, we show that CovCore proteins can be designed with predictable folds. The small organic molecule is incorporated as an intrinsic part of the protein core, forming both covalent and noncovalent interactions, which help define the unique tertiary structures. The design methodology and experimental strategies are compatible with combinatorial library screening methods and hence hold promise for a variety of applications including inhibitors of protein–protein interactions.
Mediator subunit MED25 links the jasmonate receptor to transcriptionally active chromatin
Authors: An Chunpeng , Li Lin , Zhai Qingzhe , You Yanrong , Deng Lei , Wu Fangming , Chen Rong , Jiang Hongling , Wang Hang , Chen Qian , Li Chuanyou 
Published: October 2017

Significance
Sensing of the plant hormone jasmonate (JA) by the F-box protein CORONATINE INSENSITIVE 1 (COI1) triggers profound transcriptional changes that are regulated by the master regulator MYC2. However, it remains unclear how COI1 communicates with the general transcription machinery and chromatin. Here, we show that MED25, a subunit of the Mediator coactivator complex, physically and functionally interacts with COI1 on the promoters of MYC2 targets. MED25 also physically and functionally interacts with HISTONE ACETYLTRANSFERASE1 (HAC1), which selectively regulates histone (H) 3 lysine (K) 9 acetylation of MYC2 targets. Therefore, MED25 integrates regulatory signals that converge on the promoters of MYC2 targets. Our results reveal a fundamental mechanism by which Mediator coordinates the actions of both genetic and epigenetic regulators into a concerted transcriptional program.
Echolocating bats rely on audiovocal feedback to adapt sonar signal design
Authors: Luo Jinhong , Moss Cynthia F. 
Published: October 2017

Significance
Echolocating animals are well known for their capability to extract rich information about the environment from echo returns. However, past research has not determined whether audiovocal feedback contributes to sonar call design. Audiovocal feedback is the process whereby an animal listens to the sounds it is producing and is used by both nonecholocating animals and humans to control their ongoing vocalizations. Here, we show that echolocating bats rely on audiovocal feedback, instead of echo feedback, to adapt their sonar call design in response to acoustic jamming signals. Our findings demonstrate that bats, like birds and humans, not only use audiovocal feedback to fine-tune the features of their calls, but also do so on a rapid timescale.
Fluctuation-enhanced electric conductivity in electrolyte solutions
Authors: Péraud Jean-Philippe , Nonaka Andrew J. , Bell John B. , Donev Aleksandar , Garcia Alejandro L. 
Published: October 2017

Significance
Using fluctuating hydrodynamics, we demonstrate that thermal fluctuations contribute to charge transport in binary electrolyte solutions. We show the existence of an enhancement, or renormalization, of the electric conductivity due to the coupling between fluctuations of charge and fluid velocity. This coupling results in nontrivial corrections to the classical Poisson–Nernst–Planck equations, which are of the order of the square root of the salt concentration and therefore significant even for dilute solutions. Our calculations predict a cation–anion cross-diffusion coefficient that is in quantitative agreement with experimental measurements. Our findings have important implications for the fields of both mesoscale hydrodynamics and electrolyte transport.
Mapping allele with resolved carrier status of Robertsonian and reciprocal translocation in human preimplantation embryos
Authors: Xu Jiawei , Zhang Zhen , Niu Wenbin , Yang Qingling , Yao Guidong , Shi Senlin , Jin Haixia , Song Wenyan , Chen Lei , Zhang Xiangyang , Guo Yihong , Su Yingchun , Hu Linli , Zhai Jun , Zhang Yile , Dong Fangli , Gao Yumei , Li Wenhui , Bo Shiping , Hu Mintao , Ren Jun , Huang Lei , Lu Sijia , Xie X. Sunney , Sun Yingpu 
Published: October 2017

Significance
In in vitro fertilization, it is difficult, if not impossible, with current methods to determine whether an embryo carries a chromosomal translocation. We have established a method for diagnosing chromosome abnormality named “Mapping Allele with Resolved Carrier Status” (MaReCs), which enables simultaneous screening of chromosomal ploidy and translocation in an embryo by next-generation sequencing. We demonstrate and validate that MaReCs allows accurate selection of translocation-free embryos, preventing the transmission of chromosomal translocations to future generations.
Anchoring dialogue interpreting in principles of teaching and learning
Authors: Angelelli Claudia V. 
Published: October 2017

Abstract
In today’s multilingual societies cross-linguistic communication is increasingly frequent, especially when it relates to accessing services. When providers and clients do not share a language, an interpreter, either face-to-face or remotely, steps in to enable communication. This generally occurs in the form of a dialogue in which at least three interlocutors participate. The need for learning and teaching dialogue interpreting (DI) has increased exponentially in the last decades, given the current mobility of individual providers and users as well as social phenomena such as geographic displacement of large linguistic groups. In this chapter, we build on the basic principles of teaching and learning from education and applied linguistics (specifically language pedagogy) to discuss the curriculum design of DI. Grounded on principles of student-centeredness, interpreting pedagogy and Vygotskian views on education, this chapter is a space to explore some critical areas in DI programme design such as content, staff and assessment.
It’s not about the interpreter
Authors: Ozolins Uldis 
Published: October 2017

Abstract
While a central objective of any interpreter training is to develop professional language transfer skills, dialogue interpreting sets additional challenges in coping with the interpersonal dynamics and often significantly divergent institutional status, discourse styles and communicative intent of participants. An interpreted encounter exists not for the interpreter, but for these other two or more parties, and the interpreter must perform an often complex act of transferring meaning between two parties with perhaps quite varying dispositions and expectations. Achieving this synthesis of translation competence, interpersonal performance and contextual knowledge describes the objectives of dialogue interpreting education. Such preparation differs in degree and in kind from preparation in other interpreting fields, demanding focus on social and interactional as much as on linguistic features of encounters.
Sign language interpreting education
Authors: Hammer Annemiek , van den Bogaerde Beppie 
Published: October 2017

Abstract
We present a description of our didactic approach to train undergraduate sign language interpreters on their interpersonal and reflective skills. Based predominantly on the theory of role-space by Llewellyn-Jones and Lee (2014), we argue that dialogue settings require a dynamic role of the interpreter in which s/he constantly makes choices based on contextual, interpersonal and intrapersonal factors. Reflection on the interpreter’s interpersonal skills (IPS) is essential to improve the interpreter’s behaviour. We developed several courses of Interpreting Skills (INS) offered during a four-year tertiary education programme, based on the concepts of competency-based learning and teaching. We provide a short description of one course in particular, INS7, and give some examples of practice (role-play) and (self)assessment.