bluuebunny/crossref_metadata_2025_split huggingface dataset:
Membrane fouling mechanisms and permeate flux decline model in soy sauce microfiltration
Authors: Sun Ye , Qin Zhen , Zhao Liming , Chen Qiming , Hou Qingyun , Lin Hua , Jiang Lihua , Liu Jinchang , Du Zheng 
Published: July 2017

AbstractMicrofiltration (MF) is a promising technology in soy sauce clarification. However, serious membrane fouling always lead to high operation costs, which restrict the application of the microfiltration technology. In this study, a spiral wound polyvinylidene fluoride membrane was used to explore the influences of processing conditions on membrane fouling mechanisms under total recycle mode in pilot scale. Results showed that the permeate soy sauce nearly preserved the whole nutrition and flavor substances, and the turbidity values remained below 2 NTU during 6 months' room temperature storage. Cake layer and concentration polarization resistance dominated the fouling resistances, which were influenced by operating conditions significantly. A semi‐empirical mathematical model was further proposed to quantitatively describe these influences. The predicted values of the model were consistent with the experimental data with a deviation about 10%. This is helpful for the application of membrane technology in soy sauce clarification process.Practical applicationsMicrofiltration provides soy sauce products with superior clarity. Meanwhile, it keeps most of the flavor and nutrition substances. The aim of this study is to clarify the membrane fouling mechanisms and reducing the membrane fouling in soy sauce clarification. The fouling resistance was analyzed to investigate the influences on membrane fouling under different operating parameters. The novel proposed mathematical model could be used to predict the permeate flux and describe the filtration status under different operating parameters. This study provides a theoretical basis in reducing the membrane fouling for process optimization in soy sauce microfiltration clarification. Moreover, it helps to improve the product quality and production efficiency in soy sauce microfiltration industrial application.
Policy and evidence: a critical analysis of the Year 1 Phonics Screening Check in England
Authors: Grundin Hans U. 
Published: July 2017

Abstract“This paper aims to present a critical analysis of the Year 1 Phonics Screening Check (PSC), with special focus on the relationship between the UK Department for Education's policy‐making and the evidence considered in the process of developing and evaluating the PSC. The reports from the in‐house Standards and Testing Agency and from commissioned external organisations with limited remits have been analysed, with emphasis on how the screening check findings have been used in DfE decision‐making. My conclusion is that the department has overestimated both the validity and the reliability of the check: partly because important sources of measurement error have not been explored, and partly because the available evidence has not been analysed in sufficient depth — or perhaps simply been ignored by the department. The whole phonics screening check seems to be the product of policy‐based evidence, rather than evidence‐based policy‐making. This has, in my view, seriously undermined the value of the PSC as a screening instrument, and one must wonder whether it is ‘fit for purpose’.
Room for improvement in breast milk feeding after very preterm birth in Europe: Results from the EPICE cohort
Authors: Wilson Emilija , Edstedt Bonamy Anna‐Karin , Bonet Mercedes , Toome Liis , Rodrigues Carina , Howell Elizabeth A. , Cuttini Marina , Zeitlin Jennifer ,   the EPICE Research Group
Published: July 2017

AbstractBreast milk feeding (BMF) is associated with lower neonatal morbidity in the very preterm infant (<32 weeks gestation) and breastfeeding is beneficial for maternal health. Previous studies show large variations in BMF after very preterm birth and recognize the need for targeted breastfeeding support in the neonatal intensive care units (NICU). In a European collaboration project about evidence‐based practices after very preterm birth, we examined the association between maternal, obstetric, and infant clinical factors; neonatal and maternal care unit policies; and BMF at discharge from the NICU. In multivariable analyses, covariates associated with feeding at discharge were first investigated as predictors of any BMF and in further analysis as predictors of exclusive or partial BMF. Overall, 58% (3,826/6,592) of the infants received any BMF at discharge, but there were large variations between regions (range 36–80%). Primiparity, administration of antenatal corticosteroids, first enteral feed <24 hr after birth, and mother's own milk at first enteral feed were predictors positively associated with any BMF at discharge. Vaginal delivery, singleton birth, and receiving mother's own milk at first enteral feed were associated with exclusive BMF at discharge. Units with a Baby Friendly Hospital accreditation improved any BMF at discharge; units with protocols for BMF and units using donor milk had higher rates of exclusive BMF at discharge. This study suggests that there is a high potential for improving BMF through policies and support in the NICU.
Habitual diet and diet quality in Irritable Bowel Syndrome: A case‐control study
Authors: Tigchelaar E. F. , Mujagic Z. , Zhernakova A. , Hesselink M. A. M. , Meijboom S. , Perenboom C. W. M. , Masclee A. A. M. , Wijmenga C. , Feskens E. J. M. , Jonkers D. M. A. E. 
Published: July 2017

AbstractBackgroundDiet is considered to be a key factor in symptom generation in Irritable Bowel Syndrome (IBS) and patients tend to exclude food products from their diet in pursue of symptom relief, which may impair diet quality.MethodsWe evaluated habitual dietary intake in IBS patients with regard to nutrients and food products using an extensive food frequency questionnaire. One hundred ninety‐four IBS patients were compared to 186 healthy controls using multiple logistic regression analysis. An overall diet quality score was calculated for each participant based on the criteria of the Dutch Healthy Diet (DHD) index.Key ResultsA lower DHD‐score was found for IBS (mean [SD]: 52.9 [9.6]) vs controls (55.1 [9.2], P=.02). The diet of patients was lower in fibers (21 g vs 25 g per day, P=.002) and fructose (14 g vs 16 g, P=.033), while higher in total fat (37% vs 36% of total energy intake, P=.010) and added sugars (46 g vs 44 g, P=.029). Differences in daily intake of food products included lower consumption of apples (40 g vs 69 g, P<.001), pasta (28 vs 37 g, P=.029) and alcoholic beverages (130 g vs 193 g, P=.024) and higher consumption of processed meat (38 g vs 29 g, P<.001). Some of these findings correlated with gastrointestinal symptoms, showing differences between IBS subtypes.Conclusions and InferencesDifferences in habitual diet were described, showing lower diet quality in IBS patients compared to controls, with increased consumption of fat and lower intake of fibers and fructose. Our data support the importance of personalized and professional nutritional guidance of IBS patients.
How to select a nanosimilar
Authors: Astier Alain , Barton Pai Amy , Bissig Marco , Crommelin Daan J.A. , Flühmann Beat , Hecq Jean‐Daniel , Knoeff Josefien , Lipp Hans‐Peter , Morell‐Baladrón Alberto , Mühlebach Stefan 
Published: July 2017

AbstractNanomedicines in the class of nonbiological complex drugs (NBCDs) are becoming increasingly available. Up to 23 nanomedicines have been approved, and approximately 50 are in clinical development. Meanwhile, the first nanosimilars have entered the market through the generic approval pathway, but clinical differences have been observed. Many healthcare professionals may be unaware of this issue and must be informed of these clinically relevant variances. This article provides a tool for rational decision making for the inclusion of nanomedicines into the hospital formulary, including defined criteria for evaluation of substitutability or interchangeability. The tool was generated by conducting a roundtable with an international panel of experts and follows the same thought process that was developed and published earlier for the selection of biologicals/biosimilars. In addition to the existing criteria for biosimilars, a set of seven criteria was identified that specifically apply to nanosimilars. These include (1) particle size and size distribution, (2) particle surface characteristics, (3) fraction of uncaptured bioactive moiety, (4) stability on storage, (5) bioactive moiety uptake and (6) distribution, and (7) stability for ready‐to‐use preparation. Pharmacists should utilize their pharmaceutical expertise to use the appropriate criteria to evaluate the comparability of the drug to decide on interchangeability or substitutability.
Ramesses III and the ‘Sea‐peoples’: Towards a New Philistine Paradigm
Authors: Ben‐Dor Evian Shirly 
Published: July 2017

SummaryThe Philistine paradigm attempts to answer fundamental questions in Philistine history, namely the how and when of Philistine settlement in the southern Levant. According to the traditional paradigm, the Philistines, among other ‘Sea‐Peoples’, came from the Aegean islands and were settled in Egyptian strongholds in the south Canaanite Coastal Plain in the eighth year of Ramesses III. Formulated on the basis of Egyptian texts and Philistine archaeological remains, the paradigm has been criticized over the reliability of both source materials. Therefore, it is the aim of the present study to conduct a methodological analysis of the pillars on which the paradigm rests and to offer a new reconstruction of the events that took place in the Levant in the twelfth century BCE.
Crusader Diet in Times of War and Peace: Arsur (Israel) as a Case Study
Authors: Pines Miriam , Sapir‐Hen Lidar , Tal Oren 
Published: July 2017

SummaryThis paper puts forward an archaeozoological analysis of two sizeable animal bone assemblages from the thirteenth‐century Crusader town of Arsur (Israel). Each represents a distinct behavioural practice, one of meat eaten in peaceful times and the other of meat consumed under stressful conditions while preparing for and undergoing a siege, when consideration was given to factors of benefits and space. Our results show that the faunal remains from before and during the Mamluk siege enunciate differences of subsistence and identity at the site at two different times and under diverse conditions.
The Autophagy Receptor Adaptor p62 is Up‐regulated by UVA Radiation in Melanocytes and in Melanoma Cells
Authors: Sample Ashley , Zhao Baozhong , Wu Chunli , Qian Steven , Shi Xianglin , Aplin Andrew , He Yu‐Ying 
Published: July 2017

AbstractUVA (315–400 nm) is the most abundant form of UV radiation in sunlight and indoor tanning beds. However, much remains to be understood about the regulation of the UVA damage response in melanocytes and melanoma. Here, we show that UVA, but not the shorter waveband UVB (280–315 nm), up‐regulates adaptor protein p62 in an Nrf2‐ and reactive oxygen species (ROS)‐dependent manner, suggesting a UVA‐specific effect on p62 regulation. UVA‐induced p62 up‐regulation was inhibited by a mitochondria‐targeted antioxidant or Nrf2 knockdown. In addition, p62 knockdown inhibited UVA‐induced ROS production and Nrf2 up‐regulation. We also report here a novel regulatory feedback loop between p62 and PTEN in melanoma cells. PTEN overexpression reduced p62 protein levels, and p62 knockdown increased PTEN protein levels. As compared with normal human skin, p62 was up‐regulated in human nevus, malignant melanoma and metastatic melanoma. Furthermore, p62 was up‐regulated in melanoma cells relative to normal human epidermal melanocytes, independent of their BRAF or NRAS mutation status. Our results demonstrated that UVA up‐regulates p62 and induces a p62‐Nrf2 positive feedback loop to counteract oxidative stress. Additionally, p62 forms a feedback loop with PTEN in melanoma cells, suggesting p62 functions as an oncogene in UVA‐associated melanoma development and progression.
Current reclamation practices after oil and gas development do not speed up succession or plant community recovery in big sagebrush ecosystems in Wyoming
Authors: Rottler Caitlin M. , Burke Ingrid C. , Palmquist Kyle A. , Bradford John B. , Lauenroth William K. 
Published: July 2017

AbstractReclamation is an application of treatment(s) following disturbance to promote succession and accelerate the return of target conditions. Previous studies have framed reclamation in the context of succession by studying its effectiveness in reestablishing late‐successional plant communities. Reestablishment of plant communities is especially important and challenging in drylands such as shrub steppe ecosystems where succession proceeds slowly. These ecosystems face threats from climate change, invasive species, altered fire regimes, and land‐use change, as well as fossil‐fuel extraction and associated disturbance. As such, the need for effective reclamation after this type of energy development is great. However, past research regarding this type of reclamation has focused on mining rather than oil and gas development. To better understand the effect of reclamation on rates of succession in dryland shrub steppe ecosystems, we sampled oil and gas wellpads and adjacent undisturbed big sagebrush plant communities in Wyoming, U.S.A., and quantified the extent of recovery for forbs, grasses, and shrubs on reclaimed and unreclaimed wellpads relative to undisturbed plant communities. Reclamation increased the recovery rate for early‐successional types, including combined forbs and grasses and perennial grasses, but did not affect recovery rate of late‐successional types, particularly big sagebrush and perennial forbs. Rather, subsequent analyses showed that recovery of late‐successional types was affected by soil texture and time since wellpad abandonment. This is consistent with studies in other ecosystems where reclamation has been implemented, suggesting that reclamation may not help reestablish late‐successional plant communities more quickly than they would reestablish naturally.
The Production Life Cycle
Authors: Li Ben G. , Liu Yibei 
Published: July 2017

AbstractTasks in production have different dynamics from individuals products. We build a general equilibrium model where three forces (i.e., offshoring, learning, and wage) interact to determine how production fragmentation evolves over time. We show that the production process follows a life cycle: its fragmentation emerges, deepens, and converges. Our model is stylized and versatile, and it can be used to tractably characterize the loci of global output, productivity, welfare, and value‐added distribution as production fragmentation progresses.
microRNA159‐targetedSlGAMYBtranscription factors are required for fruit set in tomato
Authors: da Silva Eder Marques , Silva Geraldo Felipe Ferreira e , Bidoia Débora Brussolo , da Silva Azevedo Mariana , de Jesus Frederico Almeida , Pino Lilian Ellen , Peres Lázaro Eustáquio Pereira , Carrera Esther , López‐Díaz Isabel , Nogueira Fabio Tebaldi Silveira 
Published: July 2017

SummaryThe transition from flowering to fruit production, namely fruit set, is crucial to ensure successful sexual plant reproduction. Although studies have described the importance of hormones (i.e. auxin and gibberellins) in controlling fruit set after pollination and fertilization, the role of microRNA‐based regulation during ovary development and fruit set is still poorly understood. Here we show that the microRNA159/GAMYB1and‐2pathway (the miR159/GAMYB1/2module) is crucial for tomato ovule development and fruit set. MiR159 andSlGAMYBswere expressed in preanthesis ovaries, mainly in meristematic tissues, including developing ovules.SlMIR159‐overexpressing tomato cv. Micro‐Tom plants exhibited precocious fruit initiation and obligatory parthenocarpy, without modifying fruit shape. Histological analysis showed abnormal ovule development in such plants, which led to the formation of seedless fruits.SlGAMYB1/2silencing inSlMIR159‐overexpressing plants resulted in misregulation of pathways associated with ovule and female gametophyte development and auxin signalling, includingAINTEGUMENTA‐likegenes and the miR167/SlARF8amodule. Similarly toSlMIR159‐overexpressing plants,SlGAMYB1was downregulated in ovaries of parthenocarpic mutants with altered responses to gibberellins and auxin.SlGAMYBslikely contribute to fruit initiation by modulating auxin and gibberellin responses, rather than their levels, during ovule and ovary development. Altogether, our results unveil a novel function for the miR159‐targetedSlGAMYBsin regulating an agronomically important trait, namely fruit set.
Clinical and pathological classification of canine intraocular lymphoma
Authors: Lanza Matthew R. , Musciano Ayla R. , Dubielzig Richard D. , Durham Amy C. 
Published: July 2017

AbstractThe objectives of this retrospective study of 100 dogs with intraocular lymphoma were to describe the histomorphologic and immunohistochemical features of canine intraocular lymphoma, determine the proportion of cases with presumed solitary ocular lymphoma (PSOL) compared to multicentric disease, and assess the clinical outcomes of these patients. Selected cases from Penn Vet Diagnostic Laboratory and Comparative Ocular Pathology Lab of Wisconsin (2004–2015) were evaluated and subtyped using the WHO classification system. Peripheral T‐cell lymphoma and diffuse large B‐cell lymphoma were the two most common subtypes. Questionnaires were distributed to the referring veterinarians and veterinary ophthalmologists inquiring about clinical signs at time of enucleation, staging, patient outcome, treatment, and disease progression. Cases were categorized as PSOL if only ocular involvement was noted at the time of diagnosis based on the clinical staging criteria. The majority of cases (61%) did not have systemic involvement at the time of diagnosis, and these cases did not progress postoperatively. Median survival time (MST) was significantly higher for the presumed solitary intraocular cases: 769 vs. 103 days, hazard ratio of 0.23 (95% CI: 0.077–0.68). The subtype of lymphoma did not affect survival time. The results of this study suggest two significant points of clinical interest: the majority of dogs (61%) presented without signs of systemic involvement of lymphoma at the time of enucleation, and dogs with only ocular involvement showed no disease progression postenucleation.
Metabolomic biomarkers of concussion
Authors: Paxman Eric James , Wanner Zachary , Boora Jyote , Douglas Kiss , Metz Gerlinde , Montina Tony , Debert Chantel 
Published: July 2017

ObjectiveTo determine if1H NMR spectroscopy of urine and a quantitative metabolomics approach can aid diagnostic and prognostic outcomes in patients who have suffered acute sport concussion.DesignPre-concussion urine samples were collected from WinSport athletes at the beginning of the sport season. Any athlete who experienced a head injury reported to a brain injury clinic to be tested within 72 hours of head injury. This testing included collection of a post-concussion urine sample for metabolomic analysis.SettingBrain injury clinic and metabolomics laboratory.Participants167 athletes entered the study with a total of 39 concussions occurring. Inclusion criteria: at least 18 years old, diagnosis of concussion, and concussion sustained within 72 hours. Exclusion criteria: multiple injuries coinciding with concussion and a past history of neurological pathology.Outcome measuresMetabolite concentrations were calculated in pre- and post-concussion urine samples and compared using a paired t-test and partial least squares discriminant analysis (PLS-DA) to determine which metabolites led to significant variation between samples.Main resultsThe PLS-DA model showed significant variation between baseline and post-injury sample groups and passed all permutation and cross-validation testing. A paired t-test, with cross-validation, isolated five significant metabolites of interest in the concussion group (p<0.05).ConclusionsUsing NMR spectroscopy we quantified urinary metabolites in patients before and after concussion. This revealed several metabolites that were shown to be significantly altered following injury, opening up future inquiry into both the pathways and processes involved in concussion and new avenues for personalized diagnosis and treatment.Competing interestsNone.
The role of environmental factors for the onset of restricted mobility outside the home among older adults with osteoarthritis: a prospective cohort study
Authors: Rantakokko Merja , Wilkie Ross 
Published: July 2017

ObjectivesThe study examines how environmental factors contribute to the onset of restricted mobility outside the home among older adults with osteoarthritis.MethodsThis is a prospective cohort study of adults aged 50 years and older with osteoarthritis (n=1802). Logistic regression tested the association between the onset of restricted mobility outside the home and health, sociodemographic and perceived environmental barriers (hills and steep slopes, inaccessible public buildings, poor pavement condition, lack of access to public parks or sport facilities, heavy traffic or speeding cars and poor weather). The potential moderating role of environmental barriers on the association between health factors and onset was examined using interaction terms and stratified analysis.ResultsOf 1802 participants, 13.5% (n=243) reported the onset of restricted mobility outside the home at 3-year follow-up. Walking disability, anxiety, depression, cognitive impairment and obesity and all environmental barriers were associated with onset after adjustment for confounders. Environmental barriers had an added contribution to the effect of the health conditions on onset of restricted mobility, which was attenuated when adjusted for confounders. The added contribution remained only for walking disability and the presence of hills and steep slopes; in the presence of both, the association with onset of restricted mobility was stronger (OR 7.66, 95% CI 4.64 to 12.64) than in the presence of walking disability (3.60, 2.43 to 5.32) or the presence of hills and steep slopes alone (4.55, 2.89 to 7.16).ConclusionFor older adults with osteoarthritis, environmental barriers are associated and add a contribution to that of morbidities and walking disability on the onset of restricted mobility outside the home. Awareness of environmental barriers is important when aiming to maintain mobility and activities outside the home despite health conditions in older adults.