bluuebunny/crossref_metadata_2025_split huggingface dataset:
O controle de constitucionalidade das políticas públicas no Brasil e a importação de modelos de controle de constitucionalidade pela Constituição de 1988
Authors: Cury Soares Hector 
Published: August 2017

O presente artigo tem como objetivos centrais apresentar o modelo de controle constitucionalidade adotado pela Constituição brasileira, bem como a origem desses modelos e os reflexos (ou possíveis) no controle da constitucionalidade. Em especial o controle da constitucionalidade das políticas públicas no Brasil. Da mesma forma, busca mostrar os possíveis limites que possam ser estabelecidos e os efeitos que, porventura, possa ter esse controle, em relação às políticas públicas. Por conseguinte, estabelece-se uma linha que permita identificar os principais problemas da importação desses modelos e tracejar critérios que possam ser universalizáveis ao controle das polí cas públicas no Brasil, carência evidenciada no direito administrativo.
Direitos humanos, povos indígenas e desenvolvimento na expansão da fronteira agrícola na Amazônia brasileira
Authors: Prado Rafael Clemente Oliveira 
Published: August 2017

O obje vo deste trabalho é analisar os mecanismos e o papel desempenhado pelas prin- cipais organizações internacionais na proteção dos direitos dos povos indígenas, enten- dendo-os como parte do rol dos direitos humanos e mencionando de forma especial o direito ao desenvolvimento dos povos indígenas, sob o recorte da expansão da fronteira na Amazônia brasileira. O método adotado para a elaboração deste trabalho é o descritivo-analítico, aplicando-se a análise documental baseada em fontes bibliográficas primárias, dando prioridade àquelas advindas de robusta doutrina e de documentos jurídicos a res- peito da matéria. O presente trabalho parte do pressuposto de que o direito dos povos indígenas de a ngirem o desenvolvimento faz parte do rol indivisível dos direitos humanos e que as organizações internacionais possuem formalmente um papel preponderante na necessidade de resguardar e proteger a universalidade e indivisibilidade dos direitos humanos dos povos indígenas, mediante os mecanismos adequados. Ademais, para que não ocorra o fenômeno de letra morta, se discu rá como esses mecanismos podem a ngir e cazmente a região da fronteira, despossuída de respeito pelos direitos humanos.
Associations Between Treatment Satisfaction, Medication Beliefs, and Adherence to Disease-Modifying Therapies in Patients with Multiple Sclerosis
Authors: Thach Andrew V. , Brown Carolyn M. , Herrera Vivian , Sasane Rahul , Barner Jamie C. , Ford Kentya C. , Lawson Kenneth A. 
Published: August 2017

AbstractBackground:Adherence to disease-modifying therapy (DMT) remains problematic for many patients with multiple sclerosis (MS). An improved understanding of factors affecting DMT adherence may inform effective interventions. This study examined associations between treatment satisfaction, medication beliefs, and DMT adherence.Methods:A survey was mailed in 2016 to 600 adult patients with relapsing-remitting MS taking an injectable or oral DMT. Patients were sampled from the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry. The survey measured self-reported DMT adherence (doses taken divided by doses prescribed during previous 2-week period—adherence ≥0.80), DMT satisfaction using the Treatment Satisfaction Questionnaire for Medication version II, medication beliefs using the Beliefs About Medicines Questionnaire, and demographic and clinical covariates. Relationships between variables were examined using multivariate logistic regression.Results:Final analyses included 489 usable surveys. Mean ± SD participant age was 60.5 ± 8.3 years. Most respondents were white (93.8%), female (86.6%), taking an injectable DMT (66.9%), and adherent to DMT (92.8%). Significant predictors of DMT adherence were age (odds ratio [OR], 1.086; 95% CI, 1.020–1.158; P = .011), type of DMT (oral vs. injectable; OR, 23.350; 95% CI, 2.254–241.892; P = .008), and DMT experience (naive vs. experienced; OR, 2.831; 95% CI, 1.018–7.878; P = .046).Conclusions:In patients with MS sampled from a patient registry, treatment satisfaction and medication beliefs were not significantly associated with DMT adherence. Based on significant predictors, younger patients, patients taking injectable DMTs, and patients with previous experience with another DMT(s) are at higher risk for nonadherence. Future research is warranted to assess relationships between variables in more diverse MS populations.
An Imaged-Based Three-Dimensional Study of First Metatarsal Protrusion Distance in Women with and Without Hallux Valgus
Authors: Rodriguez Michael W. , Pioske Kara E. , Glasoe Ward M. 
Published: August 2017

Background:First metatarsal protrusion distance (MPD) has been commonly studied as a characteristic of hallux valgus deformity. To date, the majority of investigations have used radiographic methods, with most reporting first metatarsal (ray) protrusion to be associated with deformity. As an alternative, this study used a three-dimensional (3-D) image acquisition and data analysis method to quantify MPD.Methods:Magnetic resonance images were acquired in weightbearing on 29 women (19 with hallux valgus; 10 controls). After the 3-D images were reconstructed into virtual bone models, two examiners measured MPD in relation to the navicular. In addition to a reliability analysis, a t test assessed for group differences in demographics, foot posture (hallux valgus, intermetatarsal angles), and MPD.Results:Group demographics were not different, while measures of hallux valgus and intermetatarsal angles were different (P &lt; 0.01) between groups. The measurement of MPD was highly reliable (ICC 0.99; SEM 0.78 mm). Metatarsal protrusion averaged approximately –2.0 mm in both groups. There was no statistical group difference (P = 0.89) in MPD.Conclusions:The reconstructed image datasets captured the 3-D spatial relationship of the anatomy. Measurements of MPD were reliable. The first ray measured 2 mm shorter than the second ray in both the hallux valgus and control groups. Though unexpected, this result may prompt future study of the pathokinematics associated with hallux valgus that include the quantification of metatarsal protrusion with 3-D methods, instead of relying solely on single-plane radiograph reports.
A cross-sectional study of chiropractic students' research readiness using the Academic Self-Concept Analysis Scale
Authors: Whillier Stephney , Au Kent , Feng Louie , Su Helen 
Published: August 2017

Objective:The shift toward evidence-based health care has reoriented tertiary clinical education in a way that necessitates and incorporates research. This study assesses the inclination and suitability of chiropractic students for research over a 5-year educational program.Methods:Research attributes of chiropractic students were assessed in this cross-sectional study using a validated and modified academic self-concept analysis scale. Students in first and final year were assessed in 4 domains: creativity, motivation, self-regulation, and general intellectual ability. Univariable differences were assessed using Welch 2-sample t tests, and multivariable analysis was carried out with multiple linear regression models.Results:The response rate was 71% (n = 165). First- and fifth-year students scored highly on all 4 domains (80% to 96%). Compared to first-year students, fifth-year students rated themselves significantly lower in 3 of the domains: general intellectual abilities (t[126] = −2.01; p = 0.047), motivation (t[115] = −4.82; p &lt; 0.001), and creativity (t[136] = −3.00; p = 0.003).Conclusion:Research suitability is high in chiropractic students. Both cohorts scored high in all domains despite the disparity between first and fifth years. First-year students outperformed fifth-year students in 3 domains, indicating a potential decline in the inclination to do research over time. However, unaccounted factors, such as the Dunning-Kruger effect, life changes, and “burnout,” may have contributed to these differences. Future studies should include questions about stress, fatigue, clinical orientation, and educational environment to inform the interpretation of findings.
Changes in adjustment force, speed, and direction factors in chiropractic students after 10 weeks undergoing standard technique training
Authors: Owens Edward F. , Russell Brent S. , Hosek Ronald S. , Sullivan Stephanie G.B. , Dever Lydia L. , Mullin Linda 
Published: August 2017

Objective:
To assess the force profiles of high-velocity low-amplitude thrusts delivered to a mannequin on a force platform by novice students given only verbal instructions.

Methods:
Student volunteers untrained in adjusting delivered a series of adjustments to a mannequin on a force platform. Participants performed 3 light, 3 normal, and 3 heavy thrusts on 5 listings specifying contact point, hand, and direction. Force profiles were analyzed for speed and amplitude, consistency, and force discrimination. Two recording sessions occurred 10 weeks apart.

Results:
Sixteen participants (11 females, 5 male) completed the study. Peak forces ranged from 880 to 202 N for heavy thrusts and 322- to 66 N for light thrusts. Thrust rate was from 8.1 to 1.8 Newtons per millisecond. Average coefficients of variability (CV = STD/mean) at each load level (initial/final) were heavy: 17%/15%; normal: 16%/15%; and light: 20%/20%, with 0 as ideal. A force ratio measured students' abilities to distinguish thrust magnitude. The heavy/normal ratio (initial/final) was 1.35/1.39, and the light/normal ratio was 0.70/0.67.

Conclusions:
At this point, without force feedback being used in the classroom, novice students can produce thrusts that look like those of their teachers and of experienced practitioners, but they may not produce similar speed and force values. They are consistent within and between sessions and can discriminate between light and heavy loads. A natural next step in our educational research will be to measure adjustment factors on more experienced cohorts of students with and without the presence of force-feedback training apparatus.
Mpox Clinical Presentation, Diagnostic Approaches, and Treatment Strategies
Authors: Titanji Boghuma K. , Hazra Aniruddha , Zucker Jason 
Published: October 2024

ImportanceA global outbreak of clade IIb Monkeypox virus (MPXV) infections spread rapidly across at least 118 countries resulting in a Public Health Emergency of International Concern (PHEIC) from July 2022 to May 2023. This outbreak affected more than 99 000 persons worldwide and caused more than 33 000 infections and 60 deaths in the US. In 2024, there have been approximately 200 new infections per month in the US. On August 14, 2024, the World Health Organization declared mpox a PHEIC for a second time due to a rapid increase in infections with clade I MPXV in Central Africa.ObservationsMpox is primarily acquired through direct skin to skin contact with MPXV. With clade IIb MPXV, infections are most commonly associated with sexual activity among individuals who are gay, bisexual, and other men who have sex with men. After a median incubation period of 7 to 10 days, prodromal symptoms include fever (62%-72%), lymphadenopathy (56%-86%), myalgias (31%-55%), malaise (23%-57%), and headache (25%-55%). Skin lesions progress through 4 well-defined stages (macules, papules, vesicles, and pustules) over 2 to 4 weeks. Clade IIb MPXV is typically a self-limited illness with a low mortality rate (&amp;lt;0.2% in the US); however, severe illness and death may occur in immunocompromised individuals, especially those with advanced HIV (CD4 count &amp;lt;200 cells/μL). Mpox should be suspected in patients with potential exposure to MPXV who have skin lesions, and the diagnosis is confirmed with polymerase chain reaction testing of lesions. Management is supportive and focuses on skin care and symptom relief with analgesics. While no antiviral treatments are currently approved for mpox by the US Food and Drug Administration, several therapeutics, such as tecovirimat, brincidofovir, and vaccinia immune globulin intravenous, are available through expanded access programs or clinical trials. Vaccination with the 2-dose Modified Vaccinia Ankara-Bavarian Nordic vaccine is recommended for high-incidence populations and has an efficacy of 66% to 86%.Conclusions and RelevanceMpox is a viral infection transmitted primarily through close skin to skin contact that typically causes a self-resolving illness but can result in severe illness and death in immunocompromised individuals. First-line therapy is supportive care, although patients with severe mpox infection may be treated with advanced therapeutics. Mpox vaccination is effective and, if available, should be offered to individuals at risk of exposure to mpox.
Free Summer Programming and Body Mass Index Among Schoolchildren From Low-Income Households
Authors: Beets Michael W. , Burkart Sarah , Pfledderer Christopher , Adams Elizabeth , Weaver R. Glenn , Armstrong Bridget , Brazendale Keith , Zhu Xuanxuan , Chen Brian , McLain Alexander 
Published: October 2024

ImportanceChildren experience accelerated gains in body mass index (BMI) during the summer months when school is not in session. Children from low-income households are most susceptible. Accelerated BMI gain in summer may be due to the removal of the health-promoting structure provided by schools. During summer, a common form of health-promoting structure is summer day camps (SDCs). Summer day camps are predominately fee for service, which creates a financial barrier for children from low-income households. One solution to mitigate accelerated BMI gain is providing free access to an existing SDC.ObjectiveTo investigate whether providing free access to an existing community SDC can mitigate accelerated BMI z score (zBMI) gain in elementary school–age children.Design, Setting, and ParticipantsThis randomized clinical trial was conducted during the summers of 2021, 2022, and 2023 in the southeastern United States. Participants were children (kindergarten through fourth grade) from predominantly low-income households who were randomized to attend an SDC operated by a parks and recreation commission or continue summer as usual (control).InterventionFree SDC every weekday (Monday through Friday) for 8 to 10 weeks.Main Outcomes and MeasuresThe primary outcome was between-group differences in change of zBMI measured before school ended (May) and on return to school from summer (late August). Secondary analyses examined the dose response of zBMI change with parent-reported child attendance at SDCs during the summer for all children (intervention and control).ResultsA total of 422 children (mean [SD] age, 8.2 [1.5] years; 202 [48%] female, 220 [52%] male, 292 [69%] at or below 200% federal poverty level, 127 [30%] with food insecurity) were randomized to 1 of 2 conditions: summer as usual (control, n = 199) or free SDC (n = 223). Intent-to-treat analysis indicated mean (SE) change in zBMI at the end of the summer was 0.046 (0.027) for the control and −0.048 (0.025) for the intervention group, representing a significant between-group difference of −0.094 (95% CI, −0.166 to −0.022). Dose-response analyses indicated that every 1 day per week increase in attending an SDC resulted in a −0.034 to −0.018 zBMI reduction, which translates to a gain of 0.046 to 0.080 zBMI for children never attending summer programming vs −0.09 to −0.04 zBMI reduction for children attending summer programming every weekday.Conclusions and RelevanceProviding children free access to existing community summer programming can have a meaningful effect on children’s zBMI gain during the summer. Future studies should replicate these findings across different regions and identify the optimal dose of programming to mitigate unhealthy zBMI gains.Trial RegistrationClinicalTrials.gov Identifier: NCT04072549
Hippocampal tau‐induced GRIN3A deficiency in Alzheimer's disease
Authors: Lee Sang‐Eun , Park Soomin , Kang Rian , Lee Taehoon , Yu Won Jong , Chang Sunghoe , Park Jong‐Chan 
Published: October 2024

Alzheimer's disease (AD) is characterized by significant alterations in hippocampal function and structure, but the molecular mechanisms underlying the hippocampal region remain elusive. We integrated multiple transcriptome datasets including human or rat hippocampus (GSE173955, GSE129051, GSE84422) to identify candidate genes. Subsequent analyses including gene ontology analysis and protein–protein interaction mapping were performed to identify key genes and pathways. We found that glutamate ionotropic receptor NMDA‐type subunit 3A (GRIN3A) and glutamate metabotropic receptor 8 (GRM8), which are related to the glutamatergic system, were the top two annotated genes and directly related to MAPT, which encodes a tau protein. Since there is no direct evidence of interaction between tauopathy and these genes in AD, further transcriptomic data (GSE125957, GSE56772) from tau transgenic mice and experimental validations through primary rat hippocampal neurons and induced pluripotent stem cell (iPSC)‐derived brain organoids were performed. Interestingly, we identified that decreased NR3A (encoded by GRIN3A) and mGluR8 (encoded by GRM8) are correlated with tauopathy and loss of postsynaptic function in AD. Taken together, our results identified a novel tauopathy biomarker GRIN3A in AD. Furthermore, our findings suggest that an integrated approach combining public databases and diverse experimental validations can contribute to the advancement of precision medicine therapies.
Stream‐breeding salamander use of headwater stream networks in managed forests of western Washington, USA
Authors: Ojala‐Barbour Reed , McIntyre Aimee P. , Lund Eric M. , Hayes Marc P. 
Published: October 2024

Abstract

Stream‐associated amphibians are sensitive bioindicators in headwater streams across the Pacific Northwest moist coniferous forests of North America. Much of this landscape is intensively managed for timber. Forest Practice (FP) rules determine harvest prescriptions on most private lands in Washington State and cover over 3.7 million hectares. Under these rules, non‐fish‐bearing headwater streams receive buffers on at least 50% of the stream length, including FP Sensitive Sites that receive 15–17 m radius no‐cut patch buffers.

We evaluated how torrent (Rhyacotriton spp.) and giant (Dicamptodon spp.) salamander relative abundance is influenced by headwater stream network features that correspond to FP Sensitive Sites. In particular, we examined how salamander relative abundance in the two most common FP Sensitive Sites, tributary junctions (TJs) and perennial initiation points (PIPs), compared to densities in non‐Sensitive Site stream reaches, hereafter branches. We also evaluated salamander relative abundance and two hydrologic characteristics, dry channel and seeps. We analysed data collected in 2006 and 2007 from 17 amphibian‐occupied, non‐fish‐bearing basins in Western Washington with managed forest ages 30–80.

We found no relationship between torrent salamander relative abundance and PIPs and TJs or between giant salamander relative abundance and TJs compared to branches. Consistent with expectations, giant salamander relative abundance was less in PIPs than in TJs and branches, and less in first‐order than second‐ and third‐order streams. Conversely, torrent salamander relative abundance lacked a clear relationship to stream order. Giant and torrent salamander relative abundance showed a negative relationship with the proportion of dry channels, but torrent salamanders were observed in short reaches of surface water located in predominantly dry channels.

Importantly, reaches with seeps had 123% (CI: +103% to +146%) and 81% (CI: +49% to +121%) greater relative abundance of torrent and giant salamanders, respectively, than reaches without seeps.

Practical implication: Current FP rules protect select side‐slope seeps as another category of Sensitive Sites but may too narrowly define the criteria of seeps to protect the full range of those being utilized by stream‐breeding salamanders. Studies focused on seeps and adjacent stream channel characteristics may better inform features important to stream‐breeding salamanders.
Clinical Presentation, Care Pathways, and Delays in Access to Specialized Care in Patients With Systemic Lupus Erythematosus: A Study From Lupus Midwest Network (LUMEN)
Authors: Sanchez‐Rodriguez Alain , Meade‐Aguilar Jose Antonio , Yang Jeffrey X. , Figueroa‐Parra Gabriel , Hanson Andrew C. , Langenfeld Hannah E. , Thanarajasingam Uma , Chamberlain Alanna M. , Greenlund Kurt J. , Barbour Kamil E. , Crowson Cynthia S. , Duarte‐García Alí 
Published: October 2024

ObjectiveWe aimed to characterize presentation and care pathways of patients with systemic lupus erythematosus (SLE), and delays in access to SLE‐specialized care.MethodsWe included patients with incident SLE from the Lupus Midwest Network registry. Time from the first medical encounter for SLE clinical manifestation to access to SLE‐specialized care, physician diagnosis, and treatment was estimated. Delays were defined as ≥6 months to access specialized care. We compared SLE manifestations, disease activity, and Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage indexes (SDI) between patients with and without delays. Logistic regression models assessed associations with delays.ResultsThe study included 373 patients with SLE. The median time to access SLE‐specialized care was 1.1 (95% confidence interval [CI] 0.9–1.5) months, time to diagnosis was 30.6 (95% CI 18.9–48.1) months, and time to treatment initiation was 4.7 (95% CI 3.9–8.4) months. Approximately 25% of patients (93 out of 373) experienced delays accessing specialized care, which were associated with fewer SLE manifestations at first SLE‐related encounter (fewer than two SLE domains; 92% vs 72%, P < 0.001). Patients with mucocutaneous or musculoskeletal manifestations were less likely to experience delays, whereas hematologic (odds ratio [OR] 1.71, 95% CI 1.03–2.84) or antiphospholipid antibodies domains (OR 6.05, 95% CI 2.46–14.88) were associated with delays. Delays were associated with damage at first access to SLE‐specialized care (SDI ≥1; 30% vs 7%, P < 0.001).ConclusionPatients follow a heterogeneous pathway to receive care. One‐fourth of patients experienced delays accessing SLE‐specialized care, which was associated with disease‐related damage. Fewer manifestations, hematologic manifestations, or antiphospholipid antibodies were associated with delays.image