bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maintenance pharmacotherapy after electroconvulsive therapy in inpatients with major depressive disorder: 198 prescriptions in a real-world clinical setting
Authors: Igarashi Shun , Tsuboi Takashi , Hasegawa Naomi , Ochi Shinichiro , Ohi Kazutaka , Fukumoto Kentaro , Iga Jun-ichi , Muraoka Hiroyuki , Iida Hitoshi , Kodaka Fumitoshi , Numata Shusuke , Ichihashi Kayo , Kashiwagi Hiroko , Nakamura Toshinori , Yamagata Hirotaka , Takeshima Masahiro , Nagasawa Tatsuya , Matsumoto Junya , Yamada Hisashi , Hori Hikaru , Inada Ken , Yasui-Furukori Norio , Hashimoto Ryota , Watanabe Koichiro 
Published: September 2024

Abstract

Background: Although antidepressant monotherapy is recommended for patients with major depressive disorder (MDD), they often do not respond to it, necessitating alternatives such as electroconvulsive therapy (ECT). However, maintenance pharmacotherapy after ECT has remained unestablished. With the aim of exploring real-world post-ECT maintenance pharmacotherapy, we conducted a large-scale retrospective observational study to investigate the prescription patterns at discharge in hospitalized patients with MDD.
Methods: The study was implemented as part of the EGUIDE (Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment) project, which has been published in several previous studies, and was conducted between 2016 and 2019 at 240 facilities throughout Japan that participated in the project. The 3,794 patients with MDD included in this study were divided into two groups, one that underwent ECT during hospitalization (ECT group, N = 521) and another that did not (non-ECT group, N = 3,273), for the comparison of clinical characteristics and prescription details at discharge. Statistical analyses were performed using IBM SPSS Statistics 28.0.0 (190) (IBM Japan, Tokyo, Japan). Student's t-test and chi-square test were used for statistical analysis. Bonferroni's correction was used to adjust for multiple comparisons in all chi-square tests, and a p-value of less than 1.4 x 10-3 was defined as significant.
Results: We identified 198 prescription patterns involving antidepressants in the ECT group. Analysis by drug category revealed distinctive patterns: there was no statistically significant difference in prescription rates for antidepressant monotherapy between the ECT and non-ECT groups (N = 118, 22.6% vs. N = 932, 28.4%), while the prescription rate for the combination of antidepressant monotherapy and lithium monotherapy in the ECT group was significantly higher than in the non-ECT group (N = 30, 5.7% vs. N = 35, 1.0%). Regarding the combination treatment with antidepressants and atypical antipsychotics, the ECT group (N = 188, 36.0%) was significantly higher than the non-ECT group (N = 941, 28.7%).
Conclusions: These findings highlight the complexity of treatment decisions managing of MDD after ECT and emphasize the need for structured prospective research on the effectiveness of specific maintenance pharmacotherapies after ECT.
Measurement of Copper, Zinc, Lead, and Chromium in Marine Mud Samples by Microwave Digestion ICP-OES Using Chemometric t- Test
Authors: Wang Shujia , Guan Jinan , Wan Lihua , Lu Jingsheng , Zheng Qiaoqing , Chen Kaiyue 
Published: September 2024

Abstract

Establishing an analytical method to interpret trace element changes is crucial for methane hydrate seepage tracking, exploration, and exploitation. However, research on this important issue is still limited, posing a challenge for trace element determination in marine mud samples. In this study, we first applied t-tests on independent samples for XRF tests with soil QC samples and sea mud samples. The results showed no statistically significant difference between sea mud samples and soil QC samples. Thus, soil QC samples were used for the methodology study.
We investigated the microwave digestion procedure, the selection of spectral line wavelengths for analytical tests, the limit of detection (LOD) and quantification (LOQ), spiked recoveries, precision, accuracy, and the interference of coexisting elements on spectral line selection. Results indicated that the use of inverse aqua regia and 1 mL HF as a mixed acid system is effective. Copper and zinc elements require temperatures above 150 °C, lead and cadmium above 180 °C, and chromium should not exceed 210 °C to avoid volatilization. Analytical spectra for copper, zinc, chromium, and lead were selected at 324.752, 213.857, 267.716, and 220.353 nm wavelengths. The correlation coefficients of the standard curves were above 0.9997, with detection limits ranging from 0.0004 to 0.0105 mg/L and quantification limits from 0.0017 to 0.0419 mg/L. Spiked recoveries ranged from 95.5% to 103.7%. The method's accuracy was verified using soil standard samples (GSS-4 and GSS-5). The ICP-MS method tested sea mud samples for t-test comparison, and statistical results showed no significant difference.
Unexpected hearing thresholds in a diving bird: biological relevance and methodological implications
Authors: Rößler Helen , May Anne , Dähne Michael 
Published: September 2024

Abstract

Many animals alternate between different media, such as air and water, thanks to specific adaptations. Among birds, penguins (Sphenisciformes) have the most extreme morphological, physiological, and behavioural adaptations to their amphibious lifestyle. Their auditory perception of sound, potentially matching different impedances in air and under water, is largely unknown particularly in terms of whether their underwater adaptations may have affected their in-air hearing capacity. In this context, we investigated the hearing ability of four captive Humboldt penguins (Spheniscus humboldti) in air using psychophysical hearing tests. The 50% hit rate was found to be below 76 dB rms re 20 µPa between 0.250 kHz and 10 kHz, with most sensitive hearing at 2 kHz (mean threshold of 15.3 dB rms re 20 µPa, SD = 10.6 dB, n = 4). The four penguins showed large inter-individual variation in sensitivity at a given frequency but within a common audiogram shape. Despite the variability, penguins detected 0.250 kHz at comparably low sound levels (mean ± SD = 36.8 dB rms re 20µPa ± 2.4 dB, n = 3) after a rapid decline of sensitivity at 0.500 kHz (mean ± SD = 64.1 dB rms re 20 µPa ± 9 dB, n = 4). This finding was unexpected, and it is therefore difficult to interpret whether it is an artefact of the methods or a biologically relevant finding. An extensive discussion is presented and suggests that this finding may be biologically relevant but would need further investigation to reveal the underlying mechanisms.
I-Paver QR-based OPC UA architecture for IoT retail security
Authors: R Kumar Raja D , G Hemanth Kumar , K Ayyappaswamy , C Ravindramurthy , Abas Zuraidaa Abal , B Jagadesh 
Published: September 2024

Abstract

QR code access is required for payment transactions, these details should be protected with enhanced security. Implementation of IoT devices in retail needs to have good interoperability, but it was not achieved during the transfer of data among functional units due to its large network and function. Hence, a novel technique namely, I-Paver QR-based OPC UA Architecture for IoT Retail Security is proposed to achieve effective interoperability in data transmission with knowledge of IoT devices. To obtain better interoperability a novel Psyops Products (PS) is integrated with the Open Platform Communications Unified Architecture (OPC UA) network architecture, which scans the unique characteristics of IoT devices connected in a network and prevents the generation of spatial data. In the retail counter, QR code access is the required function and there are several security challenges because of using a lot of commits such as command, acceptance, or validation services in the existing systems. To protect the data with enhanced security with minimum commits a novel method named I-PaverQR is used. To prevent the dictionary attack to avoid ineffective automation a novel Sniper- sparse code- Static prevention framework is used. This framework checks network traffic related to any attacks and vulnerability of leaked data due to dictionary attacks. Overall, the proposed method achieves more effective interoperability in data transmission than the existing systems by acquiring 98% sensitivity and Specificity, 98.62% accuracy, 99.27% precision, 99.32% Recall, and 99.48% F1-Score with knowledge of IoT devices, minimum commits to secure QR codes and protect the whole automation software from dictionary attacks.
Melittin enhances the cytotoxic effect of the targeted anticancer monoclonal antibodies on cancer cell lines
Authors: Kamal Shaimaa F. , Zedan Hamdallah , Ali Mohammed E. , Abdel-Hakeem Mohamed S. 
Published: September 2024

Abstract

Monoclonal antibodies, such as bevacizumab and cetuximab, have revolutionized targeted immunotherapy and have shown promising results in treating lung and hepatocellular carcinoma. However, a range of side effects are observed, urging the development of approaches to minimize mAb’s side effects while preserving their efficacy. Melittin, the main constituent of BV, has been recently proposed as a promising natural product for combination with immunotherapy to reduce the effective dose used. Here, we studied the impact of combining melittin with bevacizumab and cetuximab on lowering the therapeutic doses of these mAbs. We measured the effects of bevacizumab and cetuximab alone or in combination with melittin on lung and hepatocellular carcinoma cell lines (A549 and HepG2, respectively). Our results revealed enhanced cytotoxicity of bevacizumab and cetuximab in both the A549 and HepG2 cancer cell lines when either agent was combined with melittin, as calculated by the combination index from the MTT assay. These results were confirmed via histopathological examination and apoptosis analysis via flow cytometry. Mechanistically, RT‒qPCR revealed that this synergism was associated with significant changes in the gene expression of CASPASE3, Bcl2, VEGFR2, and EGFR. Our findings suggest combining melittin with bevacizumab and cetuximab enhances their effectiveness against carcinoma cell lines.
Spatially variable response of Antarctica's ice sheets to orbital forcing during the Pliocene
Authors: Patterson Molly , Rosenberg Christiana , Seki Osamu , Yamamoto Masanobu , Romero Oscar , Nelissen Mei , Sangiorgi Francesca , Golledge Nick , Grant Georgia , Arnuk William , Keisling Benjamin , Naish Tim , Levy Richard , Meyers Stephen , Sullivan Nicholas , Ash Jeanine , Kulhanek Denise , Romans Brian , Varela Natalia , Jones Harold , Beny François , Browne Imogene , Cortese Giuseppe , de Sousa Isabela Cordeiro , Dodd Justin , Esper Oliver , Gales Jenny , Harwood David , Ishino Saki , Kim Sookwan , Kim Sunghan , Laberg Jan Sverre , Leckie R. , Müller J. , Shevenell Amelia , Singh Shiv , Sugisaki Saiko , de Flierdt Tina van , Peer Tim van , Xiao Wenshen , De Santis Laura , McKay Robert 
Published: September 2024

Abstract

Variations in Earth’s orbit pace global ice-volume/sea-level changes, but the variability in the response for different sectors of the Antarctic Ice Sheet (AIS) to orbitally-forced climate change remains unclear. We present geological records of iceberg-rafted debris (IBRD) and other proxies from locations adjacent to the West Antarctic Ice Sheet (WAIS) and East Antarctic Ice Sheet (EAIS) spanning ~3.3-2.3 Ma. Iceberg calving events from the WAIS recorded in Ross Sea sediment cores show a linear response to orbital forcing at timescales corresponding to obliquity (40 kyr) and precession (23-19 kyr) modulated by eccentricity (100 kyr). This contrasts with records adjacent to the EAIS, which lack obliquity pacing. Geological data and ice sheet model sensitivity tests show the WAIS is highly dynamic and responsive to oceanic melt driven by changes in Southern Ocean circulation, together with atmospheric forcing through variations in local insolation. Conversely, the EAIS appears less responsive to oceanic forcing, despite being the dominant source of meltwater to the global ocean during the mid-Pliocene. Our results imply a significant role for atmospheric warming on mid-Pliocene sea-level.
A multi-species corridor between the Andean Amazonian and Amazon floodplain landscapes: prioritizing ecological connectivity areas for jaguar and threatened ungulates in the north-eastern of South America
Authors: Mosquera-Guerra Federico , Barreto Sebastian , Palencia-Rivera Juan D. , Velásquez-Valencia Alexander , Mantilla-Meluk Hugo , Bruges-Morales Gustavo A. , Jiménez-Ortega Alex M. , Trujillo Fernando , Armenteras-Pascual Dolors 
Published: September 2024

Abstract

The spatial heterogeneity and variability of environmental conditions in the Colombian Amazon, located in north-eastern South America, are key factors explaining the high diversity of mammal species, representing 49% of those reported for Colombia. In recent decades, the Amazon forest system has experienced accelerated transformation due to deforestation, forest fires, extensive cattle ranching, and road infrastructure development, leading to degraded natural habitats and reduced connectivity among populations of large mammals in areas ecologically important for these species. However, there has been a lack of functional connectivity analysis in the Andean Amazonian and Amazon floodplain landscapes using a multi-species approach that considers predator-prey relationships among representative groups such as large felids and wild ungulate species. To address this gap, we utilized occurrence data for focal species including the jaguar, lowland tapir, white-lipped, and collared peccaries. We developed potential distribution models, conducted binarization processes, analyzed spatial morphological patterns, and constructed a resistance matrix. This information was used to model dispersal corridors and identify nodes connecting core habitats of the focal species using the randomized shortest path algorithm, along with quantifying weighted global connectivity metrics. Our findings indicate the presence of an integrated corridor comprising potential low-cost dispersal routes for the focal species, primarily associated with the hydric network of the upper and middle Caquetá River basin. These corridors connect key protected areas such as Alto Fragua Indi Wasi, La Paya, and Serranía del Chiribiquete National Natural Parks, as well as the Cerro Páramo de Miraflores Rigoberto Urriago, Miraflores, and Picachos Regional Parks.
Concept of a Demand-Response Model for Smart Community Construction: A Case Study in Ningbo, China
Authors: Gao Chong , Zhao Xiaolong 
Published: September 2024

Abstract

Under the background of urban digital transformation in China, the construction of smart communities can add significant social values. This paper studies the needs of residents, managers, and workers of the community, and proposes a user-oriented model to increase requirement suitability and management efficiency. A case study has been carried out in Ningbo, China, to understand the user needs and the strategies adopted in the community’s digital construction process. This paper reports the study results and discusses the opportunity of using a Demand-Response Model as a universal mode for smart community construction.
Optimization of a ternary composite of CuFe2O4/CuO@rGO and its electrochemical evaluation as an electrode material for supercapacitor application
Authors: Gayathri R , Sharmila R , Vadivel S , M.Khaled jamal 
Published: September 2024

Abstract

In this study, CuFe₂O₄/CuO@rGO nanocomposites were prepared using the hydrothermal technique. In order to investigate these nanocomposite electrochemical properties, researchers constructed two-electrode and three-electrode cell configurations (asymmetric cells). The nanocomposite CuFe₂O₄/CuO@rGO showed an impressive specific capacitance that exceeded 2110 Fg−1 at a current density of 1 Ag−1. This asymmetric cell showed an impressive 40.44 Wh kg−1 energy density at a power density of 780 Wkg−1, with activated carbon (AC) acting as the anode and CuFe₂O₄/CuO@ rGO as the cathode. It also had a prolonged cycle life, with 93% retention after 10,000 cycles. By illuminating light-emitting diode (LED) lights, the asymmetric cell demonstrated the practical use of this nanocomposite as an active electrode material. By keeping its electrochemical activity steady over a variety of twisting angles, this gadget also proved its structural resilience. As far as we are aware, the synthesized nanocomposite outperformed both commercial supercapacitors and the published CuFe₂O₄/CuO@rGO-based composites when used as an active electrode material. The impressive electrochemical capability of the produced nanocomposite makes it an attractive electrode material for use in high-performance supercapacitors.
Green synthesis and characterization of zinc oxide nanoparticles using Alpinia officinarum rhizome extract for antimicrobial, antioxidant, and anti-biofilm applications
Authors: Krishnamoorthy Nishkala , Gomathi Palanisamy , Wabaidur Saikh Mohammad , Dhanusuraman Ragupathy 
Published: September 2024

Abstract

In the present study, Alphinia officinarum rhizome extract and zinc nitrate hexahydrate were utilized to synthesize eco-friendly and cost-effective zinc oxide (ZnO) nanoparticles (NPs). Nanoparticles of Zinc oxide have attained unique research interest among various metal oxides. Morphological characterizations of the ZnO NPs were analyzed using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscope (SEM) were used to characterize the ZnO NPs. FTIR spectrum revealed the presence of functional groups in ZnO NPs. XRD, scanning electron microscope, analyses confirmed the crystal structure and average size of ZnO NPs. The antimicrobial activities of ZnO NPs were tested on microorganisms, that is, P. aeruginosa ATCC 25619, MRSA ATCC 43300, and C. albicans ATCC 10231. Moreover, the antibiofilm activity of ZnO NPs was performed against P. aeruginosa ATCC 25619, MRSA ATCC 43300, and C. albicans ATCC 10231. ZnO NPs have shown effective antimicrobial and antibiofilm activities against tested microorganisms. The results elucidated that eco-friendly and cost-effectively produced ZnO NPs could be used as coating materials and in a wide range of industrial applications, such as pharmaceutical industries and cosmetics.
Rapid detection of N-lactoyl-phenylalanine for exercise evaluation using dual DNA biosensors based on solution-gated graphene field-effect transistor
Authors: Li Jiacheng , Zhang Ming , Zhang Cailing , Zhang Yin , Chen Wenbin , Liu Jian , Qu Hao , Wang Lu 
Published: September 2024

Abstract

As obesity rates continue to rise, there is an increasing focus on reducing obesity through exercise. People are becoming more aware of the importance of weight loss through physical activity. However, the effectiveness of exercise can vary significantly among individuals, making it challenging to evaluate its impact. Therefore, establishing a reliable method for assessing exercise effectiveness is crucial for enhancing exercise quality and reducing obesity risk. In this study, we developed a N-lactoyl-phenylalanine (N-Lac-Phe) biosensor by detecting L-lactic acid (L-Lac) and L-phenylalanine (L-Phe) based on Solution-Gated Graphene Field-Effect Transistors (SGGT). Our findings showed that the L-Lac and L-Phe biosensors exhibited excellent linearity within concentration ranges of 300 pM to 300 nM for L-Lac and 3 nM to 1000 nM for L-Phe, with R² values of 0.99 and 0.98. The detection accuracies for these two types of SGGT biosensors were 91.63 ± 6.97% and 99.39 ± 8.53%, respectively. Using the established N-Lac-Phe, L-Lac, and L-Phe relationship model (NLL model), we calculated the concentration of N-Lac-Phe in the RAW264.7 culture medium based on the concentrations of L-Lac and L-Phe. The biosensors demonstrated excellent accuracy, and selectivity, indicating their potential for rapidly evaluating the effectiveness of exercise.
The place of subjective emptiness in the structure of personality
Authors: Hopwood Christopher J. , Gjorgjieva Julija 
Published: September 2024

Abstract

Background
Subjective emptiness is a transdiagnostic clinical dimension related to suicide, distress, and other maladaptive outcomes. Although it is typically conceptualized as a symptom of borderline personality disorder, it has a different pattern of correlates than other symptoms of that phenotype and is present in individuals with other diagnoses. The goals of this study were to replicate and extend previous findings regarding the place of emptiness as a standalone construct within a relatively comprehensive array of personality features.
Method
A sample of 992 anonymous participants (M = 45.37 years, SD = 16.53) who were census-matched to the US population completed an online survey including measures of emptiness, normal-range and maladaptive traits, domains and aspects, and traits, values, and problems.
Results
Overall, the pattern of correlations suggests that people who report feelings of emptiness tend to have negative emotions, be socially withdrawn, and are low in energy.
Conclusion
These findings highlight the relevance of subjective emptiness beyond the borderline category, replicate previous findings regarding the personality and psychopathology correlates of subjective emptiness, and portray a particular profile of personality that represents a risk factor for the experience of subjective emptiness.
Measuring the Permeability of Seaweed as a New Sustainable Material in the Presence of Temperature
Authors: GÜNERİ Esra 
Published: September 2024

Abstract

The existing engineering properties of soils cannot always provide sufficient strength and optimization, resulting in the need for soil improvement. There are many methods and additive materials currently used in soil improvement. However, if the method to be used includes an alternative additive material, the material's sustainability, environmental friendliness and low cost play a major role considering the increasing world population and energy need. At the same time, the increasing population's demand for energy and the resulting increase in the number of energy structures increase the interaction of the soils with temperature. When all these are evaluated together, seaweed-added mixtures, terminologically known as "Zostera marina", were created within the scope of this study and their hydraulic conductivity behavior was examined under room and high temperatures. Dried seaweed is a sustainable, low-cost marine plant that has been used for thermal insulation for years in countries with a cold climate, such as Denmark. In this study, seaweed additive was added to zeolite-bentonite mixtures and hydraulic conductivity tests of the mixtures were determined under room and high temperatures (40°C). Thus, the effects of additive and temperature effects on permeability were examined separately. The test results showed that the seaweed additive had a reducing effect on hydraulic conductivity behavior at room temperature, while permeability increased under high temperature, parallel to the literature.