bluuebunny/crossref_metadata_2025_split huggingface dataset:
Actin-related protein 2/3 complex subunit 1B promotes ovarian cancer progression by regulating the AKT/PI3K/mTOR signaling pathway
Authors: Ke Miao , Zhu Huimin , Lin Yu , Zhang Ying , Tang Tao , Xie Yuhao , Chen Zhe-Sheng , Wang Xiaoyu , Shen Yuan 
Published: October 2024

Abstract

Background and Objectives
Actin-related protein 2/3 complex subunit 1B (ARPC1B) is an essential subunit of the actin-related protein 2/3 (Arp2/3) complex. While there have been numerous research reports on Arp2/3 in relation to tumors, there needs to be more research on ARPC1B and its role in tumors, particularly at the pan-cancer level.

Methods
Utilizing data from the cancer genome atlas (TCGA) and genotype-tissue expression (GTEx) databases, we analyzed ARPC1B expression differences in normal, tumor, and adjacent tissues, investigating its correlation with prognosis and clinical stages in various cancers. We conducted gene enrichment analysis and explored ARPC1B’s connection to the tumor immune microenvironment and its impact on anti-tumor drug resistance. In addition, in vivo and in vitro experiments have also been carried out to find the mechanism of ARPC1B on ovarian cancer (OV) proliferation and invasion.

Results
ARPC1B was highly expressed in 33 tumor types, suggesting its role as a tumor-promoting factor. Its expression correlated with poor prognosis and served as a clinical staging marker in over 10 tumor types. ARPC1B is implicated in various biological processes and signaling pathways, uniquely associated with tumor immunity, indicating immunosuppressive conditions in high-expression cases. High ARPC1B expression was linked to resistance to six anti-tumor drugs. Further experiments showed that ARPC1B can affect the proliferation, apoptosis, migration, and invasion of OV cells through the AKT/PI3K/mTOR pathway.

Conclusion
ARPC1B is a biomarker for immune suppression, prognosis, clinical staging, and drug resistance, providing new insights for cancer therapeutics.
The Procedure for Admitting New Members to the European Union: Legal Aspect
Authors: Mazaeva N. N. , Astapenko I. V. 
Published: October 2024

INTRODUCTION. The article is devoted to the process of accession of new states to the European Union (EU). The authors try to demonstrate the evolution of the procedure for admitting new members since the formation of the European Communities and identify the main subjects of this procedure.MATERIALS AND METHODS. The current research is based on various international legal documents, including the founding treaties of the European Union, as well as acts of EU institutions and doctrinal sources.RESEARCH RESULTS. The research represents a retrospective analysis of the formation of the procedure for accession of new members to the European Communities/EU. It was found out that the norms of the founding agreement set only the general legal framework of the procedure, and its specific content differed through out the existence of the European integration project. The actual content of the accession process is determined by the member states, which, through the institutions of the Communities/Union, primarily the Council and the European Council, formulate the criteria and principles of accession. The Commission also plays a significant role in the process. The role of the European Parliament in this procedure is insignificant, although this institution tries to increase its influence throughout the negotiation process. DISCUSSION AND COCLUSION. To sum up, the accession procedure is typologically close to a special legislative procedure. Since its origin the accession of new states to the EU has been transformed from a rule-making procedure enshrined in the founding treaties to a set of various instruments and practices, including non-legal (political) ones.
Electronic Word of Mouth dan Citra Merek The Originote di Kalangan Generasi Z
Authors: Christina Christina , Sari Wulan Purnama 
Published: October 2024

Nowadays, skincare products are widely promoted on social media. This is an example of the impact from social media development. Marketing that was done through conventional media is now starting to utilize the existence of social media and choosing Generation Z as the target market because this generation dominates the use of social media in this era. Electronic Word of Mouth marketing communication makes The Originote brand become increasingly recognized and attracts so much attention since 2022. This research aims to determine how is the impact of Electronic Word of Mouth on The Originote’s brand image. This research uses quantitative method and utilizes survey as the data-collector method. The data that has been collected from 124 respondents then tested with validity test, reliability test, and normality test. The results show the measuring instrument and data is valid, reliable, and normally distributed. The answers then processed with T-test, simple linear regression analysis and coefficient of determination. The result of T-test is 13.634 > 1.9796. The simple linear regression analysis indicates that the significance is less than 0.05. The coefficient of determination is 0.604 or 60,4%. Research result shows that Electronic Word of Mouth can helps business in creating Brand Image effectively.
Produk perawatan kulit yang kini marak dipromosikan di media sosial merupakan salah satu contoh dampak perkembangan media sosial. Pemasaran yang awalnya dilakukan melalui media konvensional kini mulai memanfaatkan keberadaan media sosial dengan menetapkan Generasi Z sebagai target pasar. Komunikasi pemasaran Electronic Word of Mouth yang terjadi terhadap merek The Originote membuat merek ini menjadi semakin dikenal dan menarik perhatian para peminat skincare. Mengetahui apakah Electronic Word of Mouth mempengaruhi citra merek The Originote adalah tujuan penelitian ini dilakukan. Penelitian ini dilakukan dengan pendekatan kuantitatif dengan metode pengumpulan data berupa survei. Data yang telah terkumpul dari 124 responden selanjutnya diuji keabsahannya dengan uji validitas, uji reliabilitas, dan uji normalitas. Hasilnya, alat ukur dan data dinyatakan valid, reliabel, dan berdistribusi secara normal. Jawaban responden selanjutnya diolah melalui uji T, analisis regresi linear sederhana, dan koefisien determinasi. Hasil uji T adalah 13,634 > 1,9796. Analisis regresi linear sederhana menunjukkan signifikansi lebih kecil dari 0,05. Koefisien determinasi menunjukkan angka 0,604. Disimpulkan bahwa Electronic Word of Mouth secara cukup kuat berpengaruh terhadap citra merek The Originote sebesar 60,4%. Maka, dapat dikatakan pemanfaatan Electronic Word of Mouth secara efektif membantu pelaku bisnis dalam membentuk citra merek.
Some Geometric Properties of Close- to- Convex Functions
Authors: Alhily Shatha S. 
Published: October 2024

The objective of this paper is to present some geometric properties of the close to convex function f when f is an analytic, univalent self-conformal mapping defined in the open unit disk D={z∈C: |z|<1}, and on the boundary of D. One of the goals of this work was determining the sharp bound for the function of form f(z)=z/(1-z)^2δ , 0<δ<1, when R(f^'/g^' (w_1))≥-2+δ/w_1 , for a some w_1∈∂D And another, if f has angular limit at p∈∂D . Then the inequality |(f^' (z))/(g^' (z) )|≥(-(1-2δ))/2(1+ δ) is sharp with extremal functions f(z)=z/(1-z)^2δ , and g(z)=z/(1+z), where 0<δ<1. Finally, if f is extended continuously to the boundary of D , then | (f^'/g^' )(p)|≥ |1-2δ|(|1-2δ|-2)/|p-δ | ; 0<δ<1.
Spectrophotometric determination of Salicylamide one of the novel COVID -19 protocols via new design Flow Injection with Merging-Zone Technique
Authors: Al-Badri Shurooq Badri , Muhamad Yasmeen H. 
Published: October 2024

Recently, attention has turned to drugs like salicylamide for treating COVID-19. Several studies have reported simple, fast, and sensitive methods for measuring salicylamide levels. However, potential limitations remain regarding interference from other drugs and accuracy of results. To tackle this issue, researchers combined the standard addition technique with flow injection analysis. As part of this investigation, the reaction involving Fe (III), salicylamide, and 1,10-phenanthroline at a temperature of 55°C was examined using a spectrophotometer set at a wavelength of 528 nm. Thus, the new design was able to show an excellent linearity over the concentration range of (2-30 μg/mL) and (25-300 μg/mL), with correlation coefficients ( ) of 0.9669 and 0.9781, respectively. In addition, physical and chemical variables were optimized to obtain the best results. There was a significant positive correlation between the new design and NIR micro-spectrometers device (handheld) outcomes.
Pemanfaatan Ma-Llow (Maternity Pillow) sebagai Upaya Peningkatan Kesehatan Fisik dan Psikis Masa Kehamilan dan Persalinan di Wilayah Puskesmas Rowosari
Authors: Munafiah Durrotun , Maftuchah Maftuchah , Ulya Fitria Hikmatul , Suhud Hargokendar , Sari Novita 
Published: October 2024

Kehamilan dan persalinan merupakan suatu periode yang special bagi wanita dan keluarganya. Periode ini dapat menghadirkan berbagai macam emosi pada wanita, alah satunya adalah kecemasan. Kecemasan dan rasa takut yang dialami oleh ibu bersalin sangat bervariasi. Kondisi ini dapat terjadi sebagai akibat dari perubahan-perubahan yang terjadi pada proses persalinan, sekitar 5-20% wanita hamil merasa takut saat proses persalinan. Berdasarkan hasil penelitian kualitatif sebagian besar ibu mengatakan bahwa persalinan identik dengan pengalaman yang menakutkan dan sakit. Salah satu cara untuk mengatasi kecemasan adalah terapi nonfarmakologi, yaitu dengan teknik distraksi. Teknik distraksi merupakan pengalihan dari fokus perhatian seseorang ke stimulus lain sehingga dapat menurunkan kecemasan. Teknik distraksi dengan menggunakan metode nonfarmakologis salah satunya dengan terapi Inovasi Ma-Llow (Maternity Pillow). Penggunaan Ma-Llow (maternity pillow) yang berhubungan dengan sistem limbik terstimulasi sehingga menghasilkan perasaan dan ekspresi. Hormon endorphine yang keluar setelah penggunaan Ma-Llow akan berguna mengurangi nyeri dan mengurangi kecemasan. Edukasi kesehatan tentang terapi nonfarmakologi Ma-Llow masih diperlukan untuk meningkatkan kesehatan fisik dan psikis pada hamil dan bersalin. Penggunaan metode seperti ceramah, demonstrasi membantu meningkatkan pengetahuan, sikap dan perilaku masyarakat. Edukasi kesehatan dilakukan pad tanggal 24 dan 31 Agustus 2024 di Puskesmas Rowosari, partisipan dalam kegiatan ini adalah 50 orang ibu hamil. Kegiatan terdiri atas 4 tahap kegiatan, yaitu: (1) pembukaan; (2) Pre Test; (3) Materi tentang Sehat Fisik dan Psikis masa kehamilan, persalinan dengan Ma-Llow; (4) diskusi; (4) penutup. Penggunaan Ma-Llow pada ibu hamil dan bersalin dapat meningkatkan kesehatan fisik dan psikis masa kehamilan dan persalinan.
A Paradigm Shift in Understanding Overuse Running-Related Injuries: Findings From the Garmin-RUNSAFE Study Point to a Sudden Not Gradual Onset
Authors: Frandsen Jesper Schuster Brandt , Simonsen Nina Sjoerup , Hulme Adam , Jacobsen Julie Sandell , Nielsen Rasmus Østergaard 
Published: October 2024

OBJECTIVES: To investigate the proportion of running-related injuries that can be classified as (1) being based on overload with an acute mechanism with a sudden onset, (2) being overuse in the sense they are based on a repetitive mechanism with a sudden onset; and (3) being overuse in the sense that runners gradually develop problems that lead to an injury. DESIGN: Cohort study with an 18-month follow-up. METHODS: English-speaking runners aged at least 18 years who were tracking running activities were included. Running-related injury during follow-up categorized into 3 groups: (1) those with overload injury, (2) those with a running-related problem 7 to 28 days prior to reporting a running-related injury, and (3) those sustaining a running-related injury without any preceding problems. RESULTS: Overload injury accounted for 467 of 1666 injuries (28%), while 1199 injuries were overuse (72%). Among overuse injuries, the proportion of runners having a problem prior to injury occurrence was 6.9% (95% confidence interval [CI]: 5.5%, 8.4%) 7 days prior to injury and 11.1% (95% CI: 9.4%, 13.0%) 28 days prior to injury. CONCLUSION: Most of the overuse injuries occurring in adult runners may be classified as sudden repetitive overuse injuries rather than injuries that are based on a gradual onset. JOSPT Open 2025;3(1):85-92. Epub 1 October 2024. doi:10.2519/josptopen.2024.0075
Optimizing Civil Construction Litigation In Indonesia: A Comprehensive Framework For Efficiency, Expertise, And Equity In Dispute Resolution
Authors: Azizan Akmal , Sophia Sally , Zahra Salma , Perai Nurajam 
Published: October 2024

Delays, excessive expenses, and a decline in public confidence come from the specialized nature of civil construction litigation in Indonesia. Several efforts have been made to improve civil construction litigation in Indonesia, such as introducing procedural reforms to expedite case processing times, increasing access to mediation and alternative dispute resolution (ADR), and the occasional involvement of technical experts to assist judges in understanding complex construction issues. Unresolved problems continue despite current attempts; a complete system redesign is required. This paper attempts to fill such knowledge gaps and provide fresh approaches to civil construction litigation in Indonesia. This study provides a comprehensive strategy to improve litigation effectiveness, efficiency, and professionalism by incorporating worldwide best practices and offering practical solutions. The research takes a methodical look at effective models in the UK, Germany, France, and Japan. It identifies critical issues in the Indonesian setting and develops specialized procedural tools like "Case Management Information Tables" and "Case Management Plan Tables." A long-term vision for the legal framework is also discussed, along with strategic approaches to expert evidence, creating a qualification and assessment system, the participation of active-standing technical advisors, and more. The study produces a versatile and all-encompassing structure for civil construction litigation in Indonesia. The research fills a need in the literature by providing valuable resources and fresh ideas for improving efficiency in legal procedures, bolstering the credibility of expert testimony, establishing stringent qualifying criteria, and encouraging long-term flexibility. The public's faith and confidence in the Indonesian legal system are bolstered due to these contributions, which increase the process's efficiency and justice.
دور القيادة الإدارية في إدارة الأزمات بالمستشفيات الحكومية بالمملكة العربية السعودية أثناء جائحة كورونا
Authors: الشمري هذلول صالح 
Published: October 2024

هدفت الدراسة إلى التعرف على أثر القيادة الإدارية على إدارة الأزمات بالمستشفيات الحكومية بالمملكة العربية السعودية أثناء جائحة كورونا. وتمثلت مشكلة الدراسة في السؤال الرئيس التالي: هل للقيادة الإدارية دور في إدارة الأزمات بالمستشفيات الحكومية بالمملكة العربية السعودية أثناء جائحة كورونا؟ استندت الدراسة على عدة فرضيات منها وجود علاقة ذات دلالة إحصائية بين القيادة الإدارية وإدارة الأزمات بالمستشفيات الحكومية بالمملكة العربية السعودية أثناء جائحة كورونا. وتأتي اهمية الدراسة في أثراء المكتبات بمادة علمية وتعتبر إضافة للرصيد الفكري والمعرفي. استخدم المنهج الوصفي، جمعت البيانات من عينة غير احتمالية (ميسرة)، وصممت استبانة لجمع البيانات تم توزيع عدد 150 استبانة، حيث بلغت نسبة الاسترداد 146 استبانة بنسبة 97%، تم بناء نموذج الدراسة وفرضياتها اعتماداً على أدبيات الدارسات السابقة. وكذلك تم الاعتماد على نمذجة المعادلة البنائية (SEM) وفيها استخدم برنامج Amos)) وتم استخدام اختبار ألفا كرنباخ للاعتمادية وأسلوب تحليل المسار لاختبار فرضيات الدارسة. توصلت الدراسة إلى وجود علاقة إيجابية بين القيادة الاوتوقراطية، وإدارة الأزمات بعد (تفتيت الأزمة)، في المستشفيات محل الدراسة، حيث بلغت قيمة بيتا (.398) بمستوى دلالة (011.). ووجود علاقة إيجابية بين القيادة الاوتوقراطية، وإدارة الأزمات بعد (احتواء الأزمة)، في المستشفيات محل الدراسة، حيث بلغت قيمة بيتا (.398) بمستوى دلالة (011.)، أوصت الدراسة بضرورة الاهتمام بتدريب العاملين وتوفير وسائل المعرفة وخلق فرص الإبداع والابتكار وتحسين الوضع النفسى والمادي لهم.
THE EFFECTIVENESS OF USING BLENDED LEARNING STRATEGY IN THE ACADEMIC ACHIEVEMENT BY SEVENTH-GRADE BASIC STUDENTS IN THE SUBJECT OF KURDISH LANGUAGE
Authors: Saeed Diyar 
Published: October 2024

The current study aims to identify the effectiveness of using the blended learning strategy in the academic achievement of seventh-grade students in the Kurdish language subject.
The research sample consisted of (114) male and female students from the seventh grade in basic education schools for boys and girls in the city of Zakho for the academic year (2022-2023). It was chosen intentionally by stratified random method from the research community according to the gender variable, then the researcher divided the sample into four equal groups in several variables based on the factorial experimental design (2X2) in the variables of teaching method and gender. The two experimental groups studied the Kurdish language subject according to the blended learning strategy, while the two control groups studied the same subject traditionally. The researcher verified the validity of the content of the test and extracted its psychometric characteristics as well as its stability. After collecting data from the research sample and processing it statistically using the two-way factor analysis of variance test according to the variables of gender, teaching method, and the interaction between them, the results indicated:
1- There is a statistically significant difference at the level (0.05) between the averages of the Kurdish language achievement among the members of the research groups according to the gender variable in favor of females and the method in favor of the blended learning strategy.
2- There is no statistically significant difference at the level (0.05) between the averages of the members of the research groups in the achievement of the Kurdish language according to the interaction of the variables of gender and method.
In light of the results, the researcher came out with several conclusions, including the possibility of applying the blended learning strategy in teaching the Kurdish language to students in basic education. The researcher also put forward some recommendations and proposals in the form of titles for future research.
Corn-Cob-Waste-Based Fe2.75Mn0.25O4/rGO Nanocomposite Application as Anti-Radar Coatings
Authors: Saefullah Lalu , Kormil Saputra  , Wida Puteri Agista  , Masruroh  , Dionysius J. D. H. Santjojo  , Istiroyah  
Published: October 2024

Radar-absorbent materials (RAMs) have become essential technologies in fields that require them, such as the military. Their working principle is that they absorb electromagnetic waves and prevent their reflection. In developing the manufacturing of RAMs, high-performance materials are needed for effective use as RAMs. In general, RAMs possess two essential properties: magnetic and dielectric. This research reports the author’s successful synthesis of an Fe2.75Mn0.25O4/rGO nanocomposite as an anti-radar material using the coprecipitation method. Interestingly, the main precursors used were natural materials, namely iron sand and corn cob waste. XRD, FTIR, and SEM-EDX characterized the research samples to determine the nanocomposite’s structure and phase, functional groups, and morphology after doping. XRD characterization results showed that Fe2.75Mn0.25O4/rGO nanoparticles had a cubic crystal structure and that there were no new peaks, which indicates that Mn had been successfully substituted into Fe. FTIR test results showed that the Fe2.75Mn0.25O4/rGO nanocomposite had Mn and Fe-O functional groups in octahedral and tetrahedral positions at wave numbers of 418 480 cm-1 and that there were C=C functional groups at the wave number of 1629 cm-1. SEM results showed that the nanocomposite comprised Fe2.75Mn0.25O4/rGO particles in agglomerated spheres and corn-cob-based rGO in sheet form, with a grain size of around 26–31 nm. EDX test results showed the appearance of Fe, Mn, O, and C elements. It was also found that the 3-mm-thick Fe2.75Mn0.25O4/rGO nanocomposite sample achieved the highest reflection loss (RL) value of -43.6 dB at a frequency of 8.5 GHz, indicating a significant radar wave absorption capability.
Analisis Nilai Sejarah Nyai Ageng Dewi Maduretno di Desa Pocong Bangkalan
Authors: Hija Qois Masholichul , Pratikno Ahmad Sudi 
Published: October 2024

<span>Penelitian ini bertujuan untuk mengetahui nilai-nilai sejarah yang ada dalam sejarah makam Nyai Ageng Dewi Maduretno. Penelitian ini merupakan penelitian istoris. Penelitian historis meneliti tentang sebuah fakta sejarah yang ada di suatu tempat. Teknik pengumpulan data yang digunakan yaitu: observasi, dokumentasi dan wawancara, Subjek penelitian berupa kompleks pemakaman N yai Ageng Dewi Maduretno yang berada di Bangkalan. Hasil penelitian ini menunjukkan bahwa, kisah hidup Nyai Ageng Dewi Maduretno berkaitan dengan masa kejayaan Majapahit, dimana Nyai Ageng Dewi Maduretno merupakan keturunan dari panglima perang kerajaan majapahit yaitu Empu Nala. Selain itu berkaitan juga dengan sejarah makam Nyai Ageng Dewi Maduretno yang menjadi asal usul dari sumber air kehidupan yang ada di Desa Pocong, Kabupaten Bangkalan</span>
Investigating the Impact of Economic Growth on Pollution Index in Emerging Market Countries
Authors: Sutikno . , Royali Ahmad S. , Sholiha Farra U. , Suliswanto M. S. Wahyudi 
Published: October 2024

This research aims to provide answers to two problems: to analyze the influence of economic, ecological, and demographic variables on environmental quality and which variables of the three have more influence on environmental quality. Using panel data analysis, with 24 Emerging Markets countries as the research objects and a series for the period between 2013 to 2022, it was found that: (a) the variables of economic growth, greenhouse gases, petrol consumption, and population influence the pollution index, while carbon emissions have no significant effect on the Pollution Index in Emerging Market countries; (b) the variables that have the greatest influence on the pollution index in emerging market countries are ecological and demographic variables compared to economic variables. Based on the findings, the implications for policy implementation are: (a) providing understanding to the public about ecology; (b) increasing population must be balanced with increasing education for the community to provide information about maintaining environmental quality; and (c) directing a sustainable economic development model in all countries through an appropriate and consistent policy framework. Theoretically, this research contributes to sharpening and understanding the flow of thinking of the Environmental Kuznets Curve (EKC) theory. Doi: 10.28991/HEF-2024-05-03-07 Full Text: PDF