bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Messinian sea-level fall in the western Black Sea: small or large? Insights from offshore Romania
Authors: Krezsek C. , Schleder Z. , Bega Z. , Ionescu G. , Tari G. 
Published: June 2016

The Messinian sea-level fall in the western Black Sea is poorly understood and often debated. We provide evidence for the sea-level fall, offshore Romania. There, the Messinian sedimentation is closely related to the gravitational collapse of the basin margin above the Maykop shales. This thin-skinned system controlled the Messinian lowstand depocentres. We estimated about 500–600 m of sea-level drop based on the erosional valleys cut into the formed lower Pontian slope and the Messinian erosional surface (MES).
The Messinian lowstand sediments are delimited by the basal erosional surface (BES) formed at the onset of the sea-level fall and by the MES related to transgressive wave erosion during the initial slow rise in sea level. Subsequent rapid sea-level rise drowned the remaining erosional topography on the lower Pontian palaeo-shelf. Similar features have been described in the Mediterranean Basin.
Early geological studies and mapping in Sweden
Authors: Sundquist Björn 
Published: June 2016

Abstract
Geological research and teaching in a modern sense started in Sweden around 1820 with the establishment of a school of mining in Falun, central Sweden. Before that time, geology-related studies were carried out by individual people at the Board of Mines and the universities in Uppsala, Lund and Åbo, along with studies in chemistry, mining, mineralogy, agriculture, or just by curiosity triggered by natural phenomena, such as the enigmatic ‘diminution of water’. In 1694, Urban Hiärne wrote and initiated the distribution of a questionnaire with the purpose of collecting information about Sweden's natural resources, some results of which he summarized a decade later. Hiärne, Magnus von Bromell, Christopher Polhem, Emanuel Swedenborg and others were the precursors who, in a sense, prepared the way for the following decades or even century of chemical, mineralogical and, eventually, geological research. The followers were Georg Brandt, Anton von Swab, Carl von Linné, Johan Gottschalk Wallerius, Axel Fredrik Cronstedt, Torbern Bergman, Carl Wilhelm Scheele, Johan Gottlieb Gahn and Wilhelm Hisinger, just to mention some of the most renowned. Samuel Gustaf Hermelin was the first person in Sweden to publish a geological map (1767), followed in 1797 by Wilhelm Hisinger, who was the first to publish an illuminated geological map.
Stratigraphic evolution of an estuarine fill succession and the reservoir characterization of inclined heterolithic strata, Cretaceous of southern Utah, USA
Authors: Johnson Cari L. , Stright L. , Purcell R. , Durkin P. 
Published: June 2016

Abstract
This study documented the architecture of a paralic succession using outcrops of the Upper Cretaceous John Henry Member of the Straight Cliffs Formation, southern Utah (USA). The 65 m thick interval of interest includes a basal succession of elongate tidal bars, which sits unconformably on the Calico Bed of the Smoky Hollow Member. These barforms are overlain by carbonaceous estuarine bay fill with tidal deposits, a bayhead delta and, ultimately, a coastal plain succession. The estuarine succession demonstrates a decreasing tidal influence through time and this is interpreted to reflect evolution from a mixed-energy to a wave-dominated estuary as a result of the changing morphology of the estuary and/or the migration of barrier islands across its mouth. The regional correlations are also discussed, with implications for sequence stratigraphic interpretations. A detailed interpretation of the ancient bayhead delta highlights the internal architecture and provides data for statistical comparison between this feature, which is dominated by inclined heterolithic strata, and a previously published study of fluvial point bar inclined heterolithic strata. The results emphasize distinct grain size trends from these two examples, as well as differences in the continuity and spatial distribution of mudstone drapes, which act as both baffles and barriers to fluid flow.
Transgressive successions of the Mahakam Delta Province, Indonesia
Authors: Lambiase Joseph J. , Riadi Ridha S. , Nirsal Nadia , Husein Salahuddin 
Published: June 2016

Abstract
Sedimentological and stratigraphic analysis of outcrops and subsurface data in the Mahakam Delta province, combined with concepts of transgressive sedimentary processes derived from a study of the modern Mahakam Delta, indicate that a significant portion of the palaeo-Mahakam Delta succession was deposited during transgressive phases. Some of the transgressive successions resulted from major transgressions and are regionally extensive, but many reflect small, short-lived transgressions within dominantly progradational phases.
Two sandstone facies with significant reservoir potential are common within the transgressive successions. Backfilled distributary sandstones occur in outcrop as 10–20 m thick, fining-upward channel sands that become more marine upward and in the subsurface as elongate, coastline-perpendicular sand bodies with a back-stepping stratigraphic architecture and highly variable thickness. Transgressive shoreline sandstones also fine upward, but they are shoreline-parallel, their lateral extent is controlled by the pre-transgression delta morphology and their thickness depends on the rate of relative sea-level rise.
Both types of transgressive sandstone can be difficult to distinguish from specific progradational sandstones with wireline log data, especially when they occur within predominantly progradational successions. However, their sand body geometries, volumetrics and connectivity are much different from the stratigraphically adjacent sandstones deposited during progradational phases of deltaic deposition.
Analysis of floodplain sedimentation, avulsion style and channelized fluvial sandbody distribution in an upper coastal plain reservoir: Middle Jurassic Ness Formation, Brent Field, UK North Sea
Authors: Flood Yvette S. , Hampson Gary J. 
Published: June 2016

Abstract

Numerical models and recent outcrop case studies of alluvial-to-coastal-plain strata suggest that autogenic avulsion can control the stacking density and architecture of channelized fluvial sandbodies. The application of these models to subsurface well data was tested by the analysis of upper coastal plain deposits of the late Bajocian Ness Formation in the Brent Field reservoir, UK North Sea. These coastal plain deposits accumulated during the progradation and retrogradation of the wave-dominated ‘Brent Delta’. Sedimentological facies analysis and palaeosol characterization in cores were used to interpret the styles of palaeochannel avulsion. These results were then compared with the dimensions and distributions of channelized fluvial sandbodies that had been quantified by spatial statistical tools (lacunarity, Besag's
L
function) applied to interpretative correlation panels between closely spaced wells. The results indicate that the distributions of channelized sandbodies may plausibly have been generated by avulsions and that they influence sandbody connectivity and pressure depletion patterns. Intervals of upper coastal plain strata with relatively wide sandbodies that display some clustering in their stratigraphic architecture are associated with a high proportion of avulsions by incision and annexation in core samples. Such intervals display relatively good vertical pressure communication and relatively slow, uniform pressure depletion.
c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer
Authors: Nebbioso Angela , Carafa Vincenzo , Conte Mariarosaria , Tambaro Francesco Paolo , Abbondanza Ciro , Martens Joost , Nees Matthias , Benedetti Rosaria , Pallavicini Isabella , Minucci Saverio , Garcia-Manero Guillermo , Iovino Francesco , Lania Gabriella , Ingenito Concetta , Belsito Petrizzi Valeria , Stunnenberg Hendrik G. , Altucci Lucia 
Published: June 2016

Abstract
Purpose: Histone deacetylase inhibitors (HDACi) are promising anticancer drugs. Although some HDACi have entered the clinic, the mechanism(s) underlying their tumor selectivity are poorly understood.
Experimental Design and Results: Using gene expression analysis, we define a core set of six genes commonly regulated in acute myeloid leukemia (AML) blasts and cell lines. MYC, the most prominently modulated, is preferentially altered in leukemia. Upon HDACi treatment, c-Myc is acetylated at lysine 323 and its expression decreases, leading to TRAIL activation and apoptosis. c-Myc binds to the TRAIL promoter on the proximal GC box through SP1 or MIZ1, impairing TRAIL activation. HDACi exposure triggers TRAIL expression, altering c-Myc-TRAIL binding. These events do not occur in normal cells. Excitingly, this inverse correlation between TRAIL and c-Myc is supported by HDACi treatment ex vivo of AML blasts and primary human breast cancer cells. The predictive value of c-Myc to HDACi responsiveness is confirmed in vivo in AML patients undergoing HDACi-based clinical trials.
Conclusions: Collectively, our findings identify a key role for c-Myc in TRAIL deregulation and as a biomarker of the anticancer action of HDACi in AML. The potential improved patient stratification could pave the way toward personalized therapies. Clin Cancer Res; 23(10); 2542–55. ©2016 AACR.
XPO1 Inhibition using Selinexor Synergizes with Chemotherapy in Acute Myeloid Leukemia by Targeting DNA Repair and Restoring Topoisomerase IIα to the Nucleus
Authors: Ranganathan Parvathi , Kashyap Trinayan , Yu Xueyan , Meng Xiaomei , Lai Tzung-Huei , McNeil Betina , Bhatnagar Bhavana , Shacham Sharon , Kauffman Michael , Dorrance Adrienne M. , Blum William , Sampath Deepa , Landesman Yosef , Garzon Ramiro 
Published: June 2016

Abstract
Purpose: Selinexor, a selective inhibitor of XPO1, is currently being tested as single agent in clinical trials in acute myeloid leukemia (AML). However, considering the molecular complexity of AML, it is unlikely that AML can be cured with monotherapy. Therefore, we asked whether adding already established effective drugs such as topoisomerase (Topo) II inhibitors to selinexor will enhance its anti-leukemic effects in AML.
Experimental Design: The efficacy of combinatorial drug treatment using Topo II inhibitors (idarubicin, daunorubicin, mitoxantrone, etoposide) and selinexor was evaluated in established cellular and animal models of AML.
Results: Concomitant treatment with selinexor and Topo II inhibitors resulted in therapeutic synergy in AML cell lines and patient samples. Using a xenograft MV4-11 AML mouse model, we show that treatment with selinexor and idarubicin significantly prolongs survival of leukemic mice compared with each single therapy.
Conclusions: Aberrant nuclear export and cytoplasmic localization of Topo IIα has been identified as one of the mechanisms leading to drug resistance in cancer. Here, we show that in a subset of patients with AML that express cytoplasmic Topo IIα, selinexor treatment results in nuclear retention of Topo IIα protein, resulting in increased sensitivity to idarubicin. Selinexor treatment of AML cells resulted in a c-MYC–dependent reduction of DNA damage repair genes (Rad51 and Chk1) mRNA and protein expression and subsequent inhibition of homologous recombination repair and increased sensitivity to Topo II inhibitors. The preclinical data reported here support further clinical studies using selinexor and Topo II inhibitors in combination to treat AML. Clin Cancer Res; 22(24); 6142–52. ©2016 AACR.
An Aggressive Subtype of Stage I Lung Adenocarcinoma with Molecular and Prognostic Characteristics Typical of Advanced Lung Cancers
Authors: Dama Elisa , Melocchi Valentina , Dezi Fabio , Pirroni Stefania , Carletti Rose Mary , Brambilla Daniela , Bertalot Giovanni , Casiraghi Monica , Maisonneuve Patrick , Barberis Massimo , Viale Giuseppe , Vecchi Manuela , Spaggiari Lorenzo , Bianchi Fabrizio , Di Fiore Pier Paolo 
Published: June 2016

Abstract
Purpose: The National Lung Cancer Screening Trial has confirmed that lung cancer mortality can be reduced if tumors are diagnosed early, that is, at stage I. However, a substantial fraction of stage I lung cancer patients still develop metastatic disease within 5 years from surgery. Prognostic biomarkers are therefore needed to identify patients at risk of an adverse outcome, who might benefit from multimodality treatment.
Experimental Design: We extensively validated a 10-gene prognostic signature in a cohort of 507 lung adenocarcinoma patients using formalin-fixed paraffin-embedded samples. Furthermore, we performed an integrated analysis of gene expression, methylation, somatic mutations, copy number variations, and proteomic profiles on an independent cohort of 468 patients from The Cancer Genome Atlas (TCGA).
Results: Stage I lung cancer patients (N = 351) identified as high-risk by the 10-gene signature displayed a 4-fold increased risk of death [HR = 3.98; 95% confidence interval (CI), 1.73–9.14], with a 3-year overall survival of 84.2% (95% CI, 78.7–89.7) compared with 95.6% (92.4–98.8) in low-risk patients. The analysis of TCGA cohort revealed that the 10-gene signature identifies a subgroup of stage I lung adenocarcinomas displaying distinct molecular characteristics and associated with aggressive behavior and poor outcome.
Conclusions: We validated a 10-gene prognostic signature capable of identifying a molecular subtype of stage I lung adenocarcinoma with characteristics remarkably similar to those of advanced lung cancer. We propose that our signature might aid the identification of stage I patients who would benefit from multimodality treatment. Clin Cancer Res; 23(1); 62–72. ©2016 AACR.
Discrimination between Winter Precipitation Types Based on Spectral-Bin Microphysical Modeling
Authors: Reeves Heather Dawn , Ryzhkov Alexander V. , Krause J. 
Published: June 2016

AbstractA new approach for distinguishing precipitation types at the surface, the spectral bin classifier (SBC), is presented. This algorithm diagnoses six categories of precipitation: rain (RA), snow (SN), a rain–snow mix (RASN), freezing rain (FZRA), ice pellets (PL), and a freezing rain–ice pellet mix (FZRAPL). It works by calculating the liquid-water fraction fw for a spectrum of falling hydrometeors given a prescribed temperature T and relative humidity profile. Demonstrations of the SBC output show that it provides reasonable estimates of fw of various-sized hydrometeors for the different categories of precipitation. The SBC also faithfully represents the horizontal distribution of precipitation type inasmuch as the model analyses and surface observations are consistent with each other. When applied to a collection of observed soundings associated with RA, SN, FZRA, and PL, the classifier has probabilities of detection (PODs) that range from 62.4% to 98.3%. The PODs do decrease when the effects of model uncertainty are accounted for. This decrease is modest for RA, SN, and PL but is large for FZRA as a result of the fact that this form of precipitation is very sensitive to small changes in the thermal profile. The effects of the choice of the degree of riming above the melting layer, the drop size distribution, and the assumed temperature at which ice nucleates are also examined. Recommendations on how to mitigate all forms of uncertainty are discussed. These include the use of dual-polarized radar observations, incorporating output from the microphysical parameterization scheme, and the use of ensemble model forecasts.
A CloudSat Perspective on the Cloud Climatology and Its Association with Aerosol Perturbations in the Vertical over Eastern China
Authors: Chen Tianmeng , Guo Jianping , Li Zhanqing , Zhao Chuanfeng , Liu Huan , Cribb Maureen , Wang Fu , He Jing 
Published: June 2016

Abstract
Many efforts have been taken to investigate aerosol–cloud interactions from space, but only a few studies have examined the response of vertical cloud structure to aerosol perturbations. Three-dimensional cloud climatologies of eight different cloud types identified from the CloudSat level-2 cloud product during the warm season (May–September) in 2008–10 over eastern China were first generated and analyzed. Using visibility as a proxy for cloud condensation nuclei, in combination with satellite-observed radar reflectivity, normalized contoured frequency by altitude diagrams of the differences in cloud radar reflectivity Z profiles under polluted and clean conditions were constructed. For shallow cumulus clouds (shallow Cu) Z tends to be inhibited, and it is enhanced in the upper layers for deep cumulus (deep Cu), nimbostratus (Ns), and deep convective clouds (DCC) under polluted conditions. Overall, analyses of the modified center of gravity (MCOG) and cloud-top height (CTH) also point to a similar aerosol effect, except for the nonsignificant changes in MCOGs and CTHs in deep Cu. The impacts of environmental factors such as lower-tropospheric stability and vertical velocity are also discussed for these types of clouds. Although consistent aerosol-induced elevations in MCOGs and CTHs for Ns and DCC clouds are observed, the effect of meteorology cannot be completely ruled out, which merits further analysis.
Interdecadal Variability of Southeastern South America Rainfall and Moisture Sources during the Austral Summertime
Authors: Martín-Gómez Verónica , Hernández-Garcia Emilio , Barreiro Marcelo , López Cristóbal 
Published: June 2016

AbstractSea surface temperature (SST) anomalies over the tropical oceans are able to generate extratropical atmospheric circulation anomalies that can induce rainfall variability and changes in the sources of moisture. The work reported here evaluates the interdecadal changes in the moisture sources for southeastern South America (SESA) during austral summer, and it is divided into two complementary parts. In the first part the authors construct a climate network to detect synchronization periods among the tropical oceans and the precipitation over SESA. Afterward, taking into account these results, the authors select two periods with different degrees of synchronization to compare the spatial distribution of the SESA moisture sources.Results show that during the last century there were three synchronization periods among the tropical oceans and the precipitation over SESA (during the 1930s, 1970s, and 1990s) and suggest that the main moisture sources of SESA are the recycling over the region, the central-eastern shore of Brazil together with the surrounding Atlantic Ocean, and the southwestern South Atlantic surrounding the SESA domain. Comparison of SESA moisture sources for the 1980s (a period of nonsignificant synchronization) and the 1990s (a synchronized period) shows that the principal differences are in the intensity of the recycling and in the strength of the central-eastern shore of Brazil. Moreover, the authors find that a region centered at (20°S, 300°E) is a moisture source for SESA only during the 1990s. These differences can be associated with the development of a low-level anticyclonic (cyclonic) anomaly circulation over central-eastern Brazil that favors the transport of moisture from central Brazil (central-eastern shore of Brazil) toward SESA in the 1990s (1980s).
Celecoxib Versus Placebo in Tonsillectomy
Authors: Van Daele Douglas J. , Bodeker Kellie L. , Trask Douglas K. 
Published: June 2016

Objectives: Celecoxib is a cyclooxygenase-2-specific inhibitor indicated to treat acute pain and pain secondary to osteoarthritis and rheumatoid arthritis. Surgical models of acute pain have demonstrated superior pain relief to placebo. The objective of this study was to test the safety and efficacy of celecoxib for pain relief after tonsillectomy compared to placebo. Methods: Adult subjects were randomized to 200 mg celecoxib versus placebo with a loading dose the night before surgery then twice daily for 10 days. Subjects were instructed to supplement the study drug with hydrocodone/acetaminophen liquid or acetaminophen for pain as needed. Subjects completed a daily diary regarding their pain, nausea, vomiting, diet, and activity. Results: Seventeen subjects enrolled. Intraoperative blood loss was similar between groups, and no subject had postoperative bleeding. Three patients returned to the emergency department for treatment, and 2 patients could not complete the diaries, all in the placebo group. Subjects in the placebo group required statistically significant ( P < .05) higher doses of narcotic and acetaminophen to control pain. Pain and diet rating scores were slightly better in the celecoxib group compared to placebo. Conclusions: In this small cohort, celecoxib reduced postoperative narcotic and acetaminophen requirements compared to placebo without complications.
Laryngeal Framework Surgery in the Irradiated Neck
Authors: Kubik Mark , Rosen Clark 
Published: June 2016

Background: Laryngeal framework surgery (LFS) remains a cornerstone treatment in the management of glottic insufficiency. Traditionally, a history of radiation to the neck has been considered a relative contraindication to LFS. Methods: A retrospective matched cohort study was performed to study LFS outcomes in patients with and without a history of radiation. Variables studied included radiation specifics, surgical time, operative difficulty, complications, need for revision surgery, and Voice Handicap Index-10 (VHI-10) scores. Results: A total of 298 patients were studied. Fourteen patients with a history of neck irradiation were matched with 14 nonirradiated controls. No complications were encountered in the nonirradiated cohort. In the irradiated cohort, there were 2 minor wound complications and 1 admission for stridor treated medically. No cases of implant extrusion were observed. The VHI-10 scores were improved in both cohorts relative to preoperative baseline ( P = .001). Posttreatment VHI-10 scores were better in the nonirradiated cohort ( P = .03). There was no difference between cohorts with respect to complication rates, surgical time, surgical difficulty, length of stay, use of a surgical drain, or need for revision surgery. Conclusion: Laryngeal framework surgery is safe and associated with improved voice outcomes in patients with a history of neck irradiation.
Markets or Hierarchies? Transaction Costs, Institutional Environment and the Foreign Collaboration Decision in India
Authors: Shankar Pragya 
Published: June 2016

Over the past few years, a growing volume of literature has analysed the forms of foreign investment to developing countries from the perspective of institutional economics, following their attempts to shift from centralised planning to a market oriented system of exchange. This article carries forward this literature and examines the relevance of the institutional factors—transaction cost theory and institutional environment—in empirically determining the modes of foreign investment and technology transfer (or foreign collaborations in India) in India. The results of this exercise show that market institutional factors like transaction costs and government policies (institutional environment) play a significant role in influencing the forms of foreign collaborations in India. However, the pattern of foreign collaborations also show a trend for higher control modes, refuting the basic hypothesis of transaction costs theory that posits a low level of ownership, unless proven otherwise. These observations can be linked to considerable market imperfections, like weak conditions relating to contract enforcement, property rights protection and ease of exit and also foreign monopoly power that hinder the market mechanism, and call for the need for strengthening the role of supporting institutions required for facilitating market exchange of transactions. JEL Classification: L22