bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of cross-orientation suppression and size tuning and the role of experience
Authors: Popović Marjena , Stacy Andrea K. , Kang Mihwa , Nanu Roshan , Oettgen Charlotte E. , Wise Derek L. , Fiser József , Van Hooser Stephen D. 
Published: October 2017

AbstractMany sensory neural circuits exhibit response normalization, which occurs when the response of a neuron to a combination of multiple stimuli is less than the sum of the responses to the individual stimuli presented alone. In the visual cortex, normalization takes the forms of cross-orientation suppression and surround suppression. At the onset of visual experience, visual circuits are partially developed and exhibit some mature features such as orientation selectivity, but it is unknown whether cross-orientation suppression or surround suppression are present at the onset of visual experience or require visual experience for their emergence. We characterized the development of these properties and their dependence on visual experience in ferrets. Visual experience was varied across three conditions: typical rearing, dark rearing, and dark rearing with daily exposure to simple sinusoidal gratings (14-16 hours total). Cross-orientation suppression and surround suppression were noted in the earliest observations, and did not vary considerably with experience. We also observed evidence of continued maturation of receptive field properties in the second month of visual experience: substantial length summation was observed only in the oldest animals (postnatal day 90); evoked firing rates were greatly increased in older animals; and direction selectivity required experience, but declined slightly in older animals. These results constrain the space of possible circuit implementations of these features.Significance StatementThe development of the brain depends on both nature – factors that are independent of the experience of an individual animal – and nurture – factors that depend on experience. While orientation selectivity, one of the major response properties of neurons in visual cortex, is already present at the onset of visual experience, it is unknown if response properties that depend on interactions among multiple stimuli develop without experience. We find that the properties of crossorientation suppression and surround suppression are present at eye opening, and do not depend on visual experience. Our results are consistent with the idea that a majority of the basic properties of sensory neurons in primary visual cortex are derived independent of the experience of an individual animal.
Government digital information discovery and exploration: the case of unraveling tourism-led-growth paradox in China
Authors: Hsu Maxwell K. , Zhang Junzhou , Ahmad Yamin 
Published: October 2017

PurposeThis study aims to examine the relationship between tourism development and economic growth while considering exports simultaneously. Governments in many countries have been developing and deploying strategies to attract tourism receipts as a means for economic growth. However, assessing the potential impact of tourism on economic growth among large economies is still in its infancy.Design/methodology/approachUsing a vector error correction model framework, this study examines the relationship among exports, gross domestic product (GDP) and tourism receipts (including international tourism receipts and domestic tourism receipts in two separate models) with macro data that covers two recent decades (1994-2013) in China.FindingsThe empirical findings confirm the existence of a long-term equilibrium relationship in each of these two tri-variate models. The empirical findings reveal that (1) both tourism-led-growth and export-led-growth hypotheses are supported, (2) the growth rate of tourism receipts exhibit a higher relevance with GDP growth than export growth and (3) the growth rate of international tourism shows a higher relevance with GDP growth than domestic tourism growth.Originality/valueUsing macroeconomic data collected by the Chinese government, the current study employs an advanced econometric methodology to explore the potential benefits of tourism on economic growth in China.
Pre-paradigmatic status of industrial sustainability: a systematic review
Authors: Smart Palie , Hemel Stefan , Lettice Fiona , Adams Richard , Evans Stephen 
Published: October 2017

Purpose
The purpose of this paper is to progress operations management theory and practice by organising contributions to knowledge production, in industrial sustainability, from disparate researcher communities. It addresses the principal question “What scholarly dialogues can be explicated in the emerging research field of industrial sustainability?” and sub-questions: what are the descriptive characteristics of the evidence base? and what thematic lines of scientific inquiry underpin the body of knowledge?

Design/methodology/approach
Using an evidenced-based approach, a systematic review (SR) of 574 articles from 62 peer-reviewed scientific journals associated with industrial sustainability is conducted.

Findings
This paper distinguishes three prevailing dialogues in the field of industrial sustainability, and uses Kuhn’s theory of paradigms to propose its pre-paradigmatic scientific status. The three dialogues: “productivity and innovation”, “corporate citizenship” and “economic resilience” are conjectured to privilege efficiency strategies as a mode of incremental reductionism. Industrial sustainability espouses the grand vision of a generative, restorative and net positive economy, and calls for a future research trajectory to address institutional and systemic issues regarding scaling-up and transition, through transformative strategies.

Research limitations/implications
The review is limited by the nature of the inquiries addressed in the literatures by specific researcher communities between 1992 and 2014.

Originality/value
This study performs the first SR in the field of industrial sustainability, synthesises prevailing scholarly dialogues and provides an evaluation of the scientific status of the field.
Skin flap vaginal augmentation helps prevent and cure post obstetric fistula repair urine leakage: a critical anatomical analysis
Authors: Browning A , Williams G , Petros P 
Published: October 2017

Our aim was to describe a new surgical method for prophylaxis/cure of post obstetric fistula repair leakage based on restoring vaginal elasticity with Singapore skin flap. The rationale for this operation was based on the integral theory: scarring removes elasticity required for independent function of oppositely acting urethral closure forces so they become ‘tethered, forcibly opening the urethra when give the signal to close'. Skin graft restores elasticity and closure. Used prophylactically with Goh type 4 fistula (n = 45), 46% were dry against an expected 19%. In patients with successful fistula closure, still with severe leakage (n = 24), 71% were dry against an expected 26%.Tweetable abstractSingapore skin flap restores elasticity and prevents and treats incontinence in patients with successful obstetric fistula repair.
Information Access and Smallholder Farmers’ Market Participation in Peru
Authors: Fan Qin , Salas Garcia Vania B. 
Published: October 2017

AbstractPrevious studies have documented the effect of information and communications technology (ICT) on farmers’ market participation. We employ a triple‐hurdle model to examine the effect of internet and phones on Peruvian smallholder farmers’ market participation, marketplace choice, and volume decisions using household‐level data from the IV National Agricultural Census of Peru in 2012. Double matching at the district‐ and household‐levels is implemented to address potential selection bias. Results indicate a positive direct effect of internet and phones on farmers’ market participation and volume decisions on the national market. Those with ICT access are more likely to sell on the foreign market than those without ICT access. The marginal effects suggest that internet access tends to have larger impacts on volume decisions than phones. In addition to direct effects, we find that internet access has significant and positive spillover effects on market participation and volume decisions in the national market. Without implementing matching procedures, the magnitude of the ICT effect tends to be smaller. Results provide empirical support for policies and social programmes that promote ICT especially internet usage in rural Peru to improve smallholder farmers’ marketing performance.
Urban commons are more‐than‐property
Authors: Williams Miriam J. 
Published: October 2017

AbstractUrban commons are characterised in the literature as collectively shared property in the city shaped by a context of scarce resources, population density, and the interaction of strangers. In the broader commons literature, commons appears as a verb, a noun, and a process made by practices of commoning—albeit still with a focus on property. In this paper, I argue that an understanding of urban commons as more‐than‐property is needed to recognise how present but elusive urban commons are. I use examples from interviews and observations conducted at a Women's Library to discuss how the access, use, benefit, care, responsibility, and ownership of this urban commons bring it into being through particular practices of commoning. By questioning current ways of defining urban commons, urban scholars gain a grounded understanding of the role of property, and other practices, in maintaining an urban commons over time.
‘My mite for its protection’: The Conservative Woman as Action Hero in the Writings of Charlotte West
Authors: Russo Stephanie 
Published: October 2017

AbstractCharlotte West's A Ten Years' Residence in France (1821) forms part of a tradition of writing about the French Revolution, yet its idiosyncratic narrator renders the text unusual. The text is a blend of travel narrative, memoir and quasi‐Gothic adventure novel. West's presentation of herself as a royalist heroine constitutes a re‐imagining of women's role within the public sphere. Her privileging of the active female political agent might seem to sit uneasily with her royalist politics, but it is within its blend of radical feminism and political conservatism that the significance of this text lies.
BDNF and BMI effects on brain structures of bipolar offspring: results from the global mood and brain science initiative
Authors: Mansur R. B. , Brietzke E. , McIntyre R. S. , Cao B. , Lee Y. , Japiassú L. , Chen K. , Lu R. , Lu W. , Li T. , Xu G. , Lin K. 
Published: October 2017

ObjectiveTo compare brain‐derived neurotrophic factor (BDNF) levels between offspring of individuals with bipolar disorders (BD) and healthy controls (HCs) and investigate the effects of BDNF levels and body mass index (BMI) on brain structures.MethodSixty‐seven bipolar offspring and 45 HCs were included (ages 8‐28). Structural images were acquired using 3.0 Tesla magnetic resonance imaging. Serum BDNF levels were measured using enzyme‐linked immunosorbent assay. Multivariate and univariate analyses of covariance were conducted.ResultsSignificantly higher BDNF levels were observed among bipolar offspring, relative to HCs (P > 0.025). Offspring status moderated the association between BDNF and BMI (F1=4.636, P = 0.034). After adjustment for relevant covariates, there was a trend for a significant interaction of group and BDNF on neuroimaging parameters (Wilks’λ F56,94=1.463, P = 0.052), with significant effects on cerebellar white matter and superior and middle frontal regions. Brain volume and BDNF were positively correlated among HCs and negatively correlated among bipolar offspring. Interactions between BDNF and BMI on brain volumes were non‐significant among HCs (Wilks’λ F28,2=2.229, P = 0.357), but significant among bipolar offspring (Wilks’λ F28,12=2.899, P = 0.028).ConclusionOffspring status and BMI moderate the association between BDNF levels and brain structures among bipolar offspring, underscoring BDNF regulation and overweight/obesity as key moderators of BD pathogenesis.
The need to exercise caution in accepting addiction as a reason for performing euthanasia
Authors: Hall Wayne , Parker Malcolm 
Published: October 2017

AbstractThe recent practice in Belgium and the Netherlands of accepting addiction as a reason for performing euthanasia raises important issues for the field of addiction and the practice of euthanasia. In this paper we outline some of these issues. We also argue that physicians making decisions about whether to accept requests for euthanasia from people with an allegedly untreatable addiction should consider two issues carefully. They should ensure that: (1) the person has the capacity to give free and informed consent to undergo euthanasia; and (2) their request is the outcome of a deliberative process in which all reasonable treatment options and harm reduction measures have been offered to and considered by the person.
Molecular characterization of the llama FGF5 gene and identification of putative loss of function mutations
Authors: Daverio M. S. , Vidal‐Rioja L. , Frank E. N. , Di Rocco F. 
Published: October 2017

SummaryLlama, the most numerous domestic camelid in Argentina, has good fiber‐production ability. Although a few genes related to other productive traits have been characterized, the molecular genetic basis of fiber growth control in camelids is still poorly understood. Fibroblast growth factor 5 (FGF5) is a secreted signaling protein that controls hair growth in humans and other mammals. Mutations in the FGF5 gene have been associated with long‐hair phenotypes in several species. Here, we sequenced the llama FGF5 gene, which consists of three exons encoding 813 bp. cDNA analysis from hair follicles revealed the expression of two FGF5 alternative spliced transcripts, in one of which exon 2 is absent. DNA variation analysis showed four polymorphisms in the coding region: a synonymous SNP (c.210A>G), a single base deletion (c.348delA), a 12‐bp insertion (c.351_352insCATATAACATAG) and a non‐sense mutation (c.499C>T). The deletion was always found together with the insertion forming a haplotype and producing a putative truncated protein of 123 amino acids. The c.499C>T mutation also leads to a premature stop codon at position 168. In both cases, critical functional domains of FGF5, including one heparin binding site, are lost. All animals analyzed were homozygous for one of the deleterious mutations or compound heterozygous for both (i.e. c.348delA, c.351_352insCATATAACATAG/c.499T). Sequencing of guanaco samples showed that the FGF5 gene encodes a full‐length 270‐amino acid protein. These results suggest that FGF5 is likely functional in short‐haired wild species and non‐functional in the domestic fiber‐producing species, the llama.
Laparoscopic pancreaticoduodenectomy in Brisbane, Australia: an initial experience
Authors: Patel Bhavik , Leung Universe , Lee Jerry , Bryant Richard , O'Rourke Nicholas , Cavallucci David 
Published: October 2017

BackgroundThe role of minimally invasive approach for pancreaticoduodenectomy has not yet been well defined in Australia. We present our early experience with laparoscopic pancreaticoduodenectomy (LPD) from Brisbane, Australia.MethodsRetrospective review in a prospectively collected database of patients undergoing LPD between 2006 and 2016 was performed. Patients who underwent a hybrid LPD (HLPD) mobilization approach and resection followed by open reconstruction and totally LPD (TLPD) approach were included in this study. Operative characteristics, perioperative outcomes, pathological and survival data were collected.ResultsTwenty‐seven patients underwent LPD including 17 HLPD (63%) and 10 TLPD (37%) patients. HLPD patients were mostly converted to open for planned reconstruction or vascular resection. With increasing experience, more TLPDs were performed, including laparoscopic anastomoses. Median operating time was 462 min (504 min for TLPD). Median length of hospital stay was 10 days. Histology showed 21 invasive malignancies, two neuroendocrine tumours, two intraductal papillary mucinous neoplasms and two benign lesions. Median nodal harvest was 22. Margin negative resection was achieved in 84% of patients. Twenty‐two percent of patients developed a Grade 3/4 complication, including 19% clinically significant pancreatic fistula. There was one perioperative mortality (4%) due to pancreatic fistula, post‐operative haemorrhage and sepsis.ConclusionsLPD is a technically challenging operation with a steep learning curve. The early oncological outcomes appear satisfactory. It remains to be determined whether the minimally invasive approach to pancreaticoduodenectomy offers benefits to patients
Hepatic cystic echinococcosis in Australia: an update on diagnosis and management
Authors: Keong Ben , Wilkie Bruce , Sutherland Tom , Fox Adrian 
Published: October 2017

BackgroundEchinococcosis is an uncommonly encountered zoonotic disease caused by the taeniid Echinococcus. The only endemic species in Australia, Echinococcus granulosus, forms cysts in the liver in 70% of cases. The aim of this study was to review the literature to provide an evidence‐based narrative update on the diagnosis and management of hepatic cystic echinococcosis in Australia.MethodsWe reviewed the literature, utilizing multiple research databases and citation tracking. Original research and review articles examining the diagnosis and management of hydatid disease in adults, published prior to 2016 and in the English language were included in our review.ResultsUltrasound is the gold‐standard screening test, whilst computed tomography has a role in emergency presentations and screening for multi‐organ involvement. Magnetic resonance imaging is the preferred second‐line imaging and better demonstrates biliary involvement. Medical therapy or PAIR (percutaneous aspiration, irrigation with scolicide and re‐aspiration) may be appropriate in selected cases; however, surgery remains the definitive treatment for active, large (>5 cm), symptomatic or complicated cysts. A variety of surgical techniques have been described, including conservative, radical and minimally invasive procedures. There is currently no consensus approach; surgical modality should be tailored to patient factors, relevant anatomy, local facilities and surgeons’ expertise.ConclusionDiagnosis and therapy in hepatic hydatid cysts have been significantly advanced by imaging, interventional radiology and surgical approaches in recent years. Surgery remains the mainstay of treatment for large, active, complicated or symptomatic hepatic hydatid cysts.
The differences in the eyelids microstructure and the conjunctiva‐associated lymphoid tissue between selected ornamental and wild birds as a result of adaptation to their habitat
Authors: Klećkowska‐Nawrot Joanna E. , Goździewska‐Harłajczuk Karolina , Łupicki Dariusz , Marycz Krzysztof , Nawara Tomasz , Barszcz Karolina , Kowalczyk Artur , Rosenberger Joanna , Łukaszewicz Ewa 
Published: October 2017

AbstractThe aim of the study was to describe the morphology of the upper, lower and third eyelid and characterize the organized lymphoid follicles and diffuse lymphocytes from ornamental and wild birds. The goal of these examinations was also to identify avian conjunctiva‐associated lymphoid tissue (CALT) and lymphoid tissue that contained specialized high endothelial venules. The upper, lower and third eyelid from 30 species of ornamental and wild birds representing 21 families were examined under light microscopy and using scanning electron microscopy. The third eyelid in all of the examined birds was composed of a free margin, which was divided into two parts. The largest tarsal plate of the third eyelid was observed in the greater rhea (Rheimorphae), the white‐tailed eagle and steppe eagle (Accipitrimorphae) and was approximately 13–15 mm wide and 9–11 mm long, respectively. In all of the examined birds, the CALT was associated with a rich network of small vessels. In addition, the presence of characteristic high endothelial venules and roundish bright endothelial cells was confirmed in the upper and lower eyelids or only in the lower eyelid (Phoenicopterimorphae, Procellariimorphae and Strigimorphae).
Higher Levels of Cystatin C in HIV/AIDS Patients with Metabolic Syndrome
Authors: Dragović Gordana , Srdić Danica , Al Musalhi Khawla , Soldatović Ivan , Kušić Jovana , Jevtović Djordje , Nair Devaki 
Published: October 2017

AbstractData about Cystatin‐C levels in HIV‐infected patients with metabolic syndrome (MetS) are still limited. Therefore, the aim of this study was to evaluate the possible correlations of serum levels of Cystatin‐C in HIV/AIDS patients treated with combined antiretroviral therapy (cART) with or without MetS. This cross‐sectional study included 89 HIV/AIDS Caucasian patients receiving cART at the HIV/AIDS Centre Belgrade, Serbia, divided into two groups according to the presence of MetS. Cystatin‐C and other biochemical parameters were measured using Cytokine‐Array‐I, Metabolic‐Array‐I and Metabolic‐Array‐II, at the Department of Clinical Biochemistry, Royal Free Hospital and University College London, UK. A linear regression model was performed to evaluate which clinical and laboratory variables had an independent effect on Cystatin‐C levels in HIV/AIDS patients. There were 33 (37%) patients with MetS and 56 (63%) without MetS. Patients with and without MetS were homogenous for age, duration of cART, number of cART combinations and CD4+ T cell count. Statistically increased Cystatin‐C levels were observed in HIV/AIDS patients with MetS (p = 0.017), when compared to patients without MetS. Data showed a positive correlation of Cystatin‐C and C‐reactive protein (r = 0.349, p = 0.001). Using linear regression modelling, significant correlations were obtained between Cystatin‐C and MetS in univariate analysis (p < 0.001). Cystatin‐C levels were significantly higher in HIV/AIDS patients with MetS versus without MetS. Early assessment of MetS using Cystatin‐C as a marker may ultimately help increase the lifespan of HIV/AIDS patients, as these patients appear to be at high risk of cardiovascular diseases.
Disrupted cortico‐limbic connectivity during reward processing in remitted bipolar I disorder
Authors: Dutra Sunny J , Man Vincent , Kober Hedy , Cunningham William A , Gruber June 
Published: October 2017

ObjectivesBipolar disorder (BD) is associated with elevated reward sensitivity and persistent positive affect, yet the neural mechanisms underlying these patterns are not well understood. In the present study, we examined putative disruptions in communication within a well‐known cortico‐limbic reward circuit during reward processing as a potential contributing mechanism to these symptoms.MethodsThe present investigation employed a within‐ and between‐subjects design utilizing a monetary and social incentive delay task among adults with bipolar disorder type I (BD; N = 24) and a healthy non‐psychiatric control group (HC; N = 25) during functional magnetic resonance imaging (fMRI). Participants in the BD group were remitted at the time of testing.ResultsFunctional connectivity analyses revealed increased connectivity between the ventral striatum (VS) seed region and orbitofrontal cortex (OFC) as well as the amygdala during processing of reward receipt in the BD group. After omission of expected rewards, the BD group showed decreased functional connectivity between the VS and a medial frontopolar cortex (mFPC) region associated with consideration of behavioral alternatives. Follow‐up analyses within the BD group showed that increased VS‐OFC connectivity after reward receipt, and decreased VS‐mFPC connected after reward omission, were associated with higher levels of subthreshold mania symptoms.ConclusionsResults point toward potential mechanisms implicated in elevated reward sensitivity in BD. Enhanced VS‐OFC connectivity after reward receipt may be involved in elevated valuation of rewards whereas blunted VS‐mFPC connectivity after reward omission may reflect a failure to consider behavioral alternatives to reward pursuit.