bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel opioid/pramipexole combination treatment for the management of acute pain: a pilot study
Authors: Girardi Cara , Duronio Joseph , Patton Ryan , O’Brien Kevin , Clemens Stefan , Brewer Kori L. 
Published: September 2024

PurposeDespite their dangerous side effects, opioid drugs remain a standard of care for moderate to severe pain with few alternatives. Strategies to maintain the analgesic effects of opioids while minimizing the associated risks are needed. Pre-clinical studies have shown using a dopamine 3 receptor (D3R) agonist as an adjuvant to morphine provides superior analgesia against painful stimuli compared to morphine alone. Our objective was to test if adjunct treatment with a D3R agonist can lead to a reduction in opioid use while maintaining effective analgesia.Patients and methodsThis study was set up as a double-blinded, placebo-controlled randomized trial. Enrollment included acute renal colic patients presenting to the emergency department, from which patients were randomized to either the “control” or “study arm”. The control group received standard treatment of care (morphine, 0.1 mg/kg; i.v.) and an oral placebo pill. The experimental group received half-dosed morphine and oral pramipexole pill (0.25 mg). Pain measurements including a numerical pain scale and visual analog scale were collected from enrollees at baseline and every subsequent 15 min.ResultsA total of 19 patients completed the study, 10 in the experimental arm and 9 in the control arm. During the study period, effective analgesia (50% decrease from baseline) was achieved in 80% of patients in the experimental arm vs. 33.3% in the control arm.ConclusionOur pilot clinical trial demonstrated that D3R recruitment can serve as an effective adjuvant to low-dose morphine for control of renal colic pain and potentially other acute pain conditions.
Clinical Trial RegistrationClinicalTrials.gov, identifier, (NCT04160520).
Lithocarpus polystachyus Rehd. ameliorates cerebral ischemia/reperfusion injury through inhibiting PI3K/AKT/NF-κB pathway and regulating NLRP3-mediated pyroptosis
Authors: Liu Daifang , Wu Wendan , Wang Tingting , Zhan Guiyu , Zhang Yuandong , Gao Jianmei , Gong Qihai 
Published: September 2024

IntroductionIschemic stroke (IS) is a serious threat to human life and health, and cerebral ischemia/reperfusion injury (CIRI) exacerbates IS by enhancing neuroinflammation and oxidative stress. Sweet tea (ST) comprises several bioactive components, such as phlorizin, trilobatin, and phloretin, with diverse pharmacological activities. However, it remains uncertain whether ST can confer protection against CIRI. In this study, we aimed to investigate the impact and potential underlying mechanism of ST in the context of CIRI.MethodsCIRI model were established in male sprague dawley (SD) rats. The neurobehavioral assessment, the volume of cerebral infarction and the morphology of neurons were measured to complete the preliminary pharmacodynamic study. The therapeutic targets and pathways of ST on IS were obtained by protein-protein interaction, molecular docking and Metascape database. The predicted results were further verified in vivo.ResultsOur results revealed that ST treatment significantly ameliorated brain damage in rats subjected to CIRI by mitigating mitochondrial oxidative stress and neuroinflammation. Additionally, we identified the PI3K/AKT/NF-κB pathway and the NLRP3-mediated pyroptosis axis as crucial processes, with molecular docking suggested direct interactions between the main compounds of ST and NLRP3.ConclusionST safeguards against CIRI-induced neuronal loss, neuroinflammation and oxidative stress through the inhibition of the PI3K/AKT/NF-κB pathway and the regulation of NLRP3-mediated pyroptosis.
SAL0114: a novel deuterated dextromethorphan-bupropion combination with improved antidepressant efficacy and safety profile
Authors: Xiao Ying , Hu Xuefeng , Xing Wei , Yan Jie , Wang Ruhuan , Li Xiaoqing , Li Jiahuan , Zhang Zhixin , Sun Jingchao , Wu Junjun 
Published: September 2024

BackgroundEsketamine, the first Food and Drug Administration-approved fast-acting antidepressant, has limited use because of its addictive properties. Although the combination of dextromethorphan and bupropion partially addresses the limitations of esketamine, concerns remain regarding neurologic side effects related to dextromethorphan metabolites, and seizure risks associated with high-dose bupropion. SAL0114, a novel formulation combining deuterated dextromethorphan (in which hydrogen atoms are replaced with deuterium) with bupropion, seeks to enhance dextromethorphan stability through deuteration of its metabolic sites. This approach is expected to increase antidepressant efficacy, reduce metabolite-induced safety issues, and allow for lower bupropion dosages.MethodsRadioligand competition binding assays were used to evaluate the impact of deuterium substitution on the in vitro activity of dextromethorphan and its metabolite, dextrorphan. In vitro hepatic microsomal stability and in vivo mouse pharmacokinetic assays were performed to assess the effects of deuteration on dextromethorphan stability. Two mouse models of behavioral despair were used to determine the antidepressant and synergistic effects of deuterated dextromethorphan and bupropion. Additionally, a reserpine-induced hypothermia rat model and an ammonia-induced cough mouse model were used to assess the in vivo effects from a pathological perspective.ResultsDeuterated dextromethorphan maintained the same in vitro activity as dextromethorphan while exhibiting twice the metabolic stability both in vitro and in vivo. Combination with bupropion further improved its in vivo stability, increasing the exposure by 2.4 times. The combination demonstrated efficacy and synergistic effects in all tested animal models, showing superior efficacy compared with the dextromethorphan-bupropion combination.ConclusionDeuteration improved dextromethorphan metabolic stability without altering its in vitro activity. Bupropion enhanced this stability and synergistically boosted the antidepressant effect by increasing deuterated dextromethorphan exposure in vivo. This enhanced metabolic stability suggests a reduction in dextromethorphan metabolites associated with clinical neurological side effects. Consequently, SAL0114 is hypothesized to offer improved efficacy and safety compared with the non-deuterated combination, potentially allowing for lower bupropion dosages. Further clinical studies are required to confirm these preclinical findings.
Protonophore treatment augments energy expenditure in mice housed at thermoneutrality
Authors: Sadler Daniel G. , Landes Reid D. , Treas Lillie , Sikes James , Porter Craig 
Published: September 2024

BackgroundSub-thermoneutral housing increases facultative thermogenesis in mice, which may mask the pre-clinical efficacy of anti-obesity strategies that target energy expenditure (EE). Here, we quantified the impact of protonophore treatment on whole-body energetics in mice housed at 30°C.MethodsC57BL/6J mice (n = 48, 24M/24F) were housed at 24°C for 2 weeks; 32 (16M/16F) were then transitioned to 30°C for a further 4 weeks. Following 2 weeks acclimation at 30°C, mice (n = 16 per group, 8M/8F) received either normal (0 mg/L; Control) or supplemented (400 mg/L; 2,4-Dinitrophenol [DNP]) drinking water. Mice were singly housed in metabolic cages to determine total EE (TEE) and its components via respiratory gas exchange. Mitochondrial respiratory function of permeabilized liver tissue was determined by high-resolution respirometry.ResultsTransitioning mice from 24°C to 30°C reduced TEE and basal EE (BEE) by 16% and 41%, respectively (both P &lt; 0.001). Compared to 30°C controls, TEE was 2.6 kcal/day greater in DNP-treated mice (95% CI: 1.6–3.6 kcal/day, P &lt; 0.001), which was partly due to a 1.2 kcal/day higher BEE in DNP-treated mice (95% CI: 0.6–1.7 kcal/day, P &lt; 0.001). The absolute TEE of 30°C DNP-treated mice was lower than that of mice housed at 24°C in the absence of DNP (DNP: 9.4 ± 0.7 kcal/day vs. 24°C control: 10.4 ± 1.5 kcal/day). DNP treatment reduced overall body fat of females by 2.9 percentage points versus sex-matched controls (95% CI: 1.3%–4.5%, P &lt; 0.001), which was at least partly due to a reduction in inguinal white fat mass.ConclusionProtonophore treatment markedly increases EE in mice housed at 30°C. The magnitude of change in TEE of mice receiving protonophore treatment at 30°C was smaller than that brought about by transitioning mice from 24°C to 30°C, emphasizing that housing temperature must be considered when assessing anti-obesity strategies that target EE in mice.
The relationship between work–family conflict and job burnout among primary and secondary school teachers: the role of depression and cognitive reappraisal
Authors: Li Yue , Ni Xingcan , Zhang Wei , Wang Jianping , Yu Chengfu , Zou Hongyu 
Published: September 2024

BackgroundPrimary and secondary school teachers are a high-risk group for job burnout, and how to alleviate their job burnout has become an increasingly urgent issue. Previous studies have paid less attention to the differential effects of the bidirectional interaction between work and family on the job burnout of the teachers. This study aim to explore the different impact of work–family conflict and family–work conflict on job burnout among primary and secondary school teachers, as well as its underlying mechanisms.MethodsThis study selected 2,184 primary and secondary school teachers in China (Mage = 37.26; SD = 9.40) as participants using a random sampling method. Using the SPSS Process 4.0 macro plugin constructed a moderated mediation model, the study explored the relationships between two different forms of work–family conflict, depression, cognitive reappraisal, and job burnout.ResultsThe study results indicated that both forms of work–family conflict were significantly positively related to the job burnout, and this relationship was influenced by the mediating role of depression. Furthermore, cognitive reappraisal moderated the relationship between depression and job burnout.ConclusionThis study revealed the potential pathways influencing job burnout among primary and secondary school teachers in the Chinese cultural context. Focusing on and alleviating work–family conflicts for primary and secondary school teachers is crucial for mitigating their occupational burnout. Additionally, teachers should also carefully and reasonably use cognitive reappraisal as an emotional regulation strategy to adjust the impact of depression on occupational burnout.
Association between aromatic amines and serum neurofilament light chain as a biomarker of neural damage: a cross-sectional study from NHANES
Authors: Lin Tong , Mao Haiyan , Huang Shanshan , Chen Jialu 
Published: September 2024

BackgroundAromatic amines (AAs) are a group of compounds widely found in chemical industry, tobacco smoke, and during food processing, with established carcinogenic properties. To date, there have been no reports on the potential neurotoxic effects of adult exposure to AAs. Serum neurofilament light chain (sNfL) is a protein released into the bloodstream following nerve axon injury and has been validated as a reliable biomarker for various neurological diseases. However, there has been no research to investigate the relationship between AAs exposure and sNfL.MethodsIn this study, we selected adults (aged ≥20 years) with data on both AAs and sNfL from the National Health and Nutrition Examination Survey (NHANES) conducted in 2013–2014. We used multivariable linear regression models to explore the correlation between urinary AAs and sNfL.ResultsIn total, 510 adult participants with an average age of 43.58 ± 14.74 years were included in the study. Our findings indicate that, based on univariate linear regression and between-group comparative analyses, 1-Aminonaphthalene (1-AN), 2-Aminonaphthalene (2-AN), 4-Aminobiphenyl (4-AN) and o-Anisidine (o-ANI) showed a positive correlation with serum neurofilament light chain (P &lt; 0.05). However, multiple linear regression analysis revealed that only 2-AN exhibited a positive correlation with serum neurofilament light chain (P &lt; 0.05), while the correlations of other compounds with serum neurofilament light chain became non-significant.ConclusionAlthough our cross-sectional study fails to establish causal relationships or determine clinical significance, the findings indicate a potential association between adult exposure to AAs, notably 2-AN, and nerve damage. Consequently, further research is needed to explore the connection between AAs exposure, sNfL, and neurological conditions in adults.
Association between Internet use and depression among older adults in China: the chain-mediating role of volunteer activity participation and friend network
Authors: Liu Yujiang , Li Fang , Sun Jian 
Published: September 2024

BackgroundDepression is a significant burden on individuals and society, which requires our attention and action. As the aging wave collides with digitalization, further research is needed to understand how internet use relates to depression in older adults. This study aimed to investigate whether volunteer activity participation and friend networks played a chain mediating role in this relationship from the perspective of the socioemotional selectivity theory.MethodThis study’s data was derived from the 2018 China Longitudinal Aging Social Survey (CLASS), comprising 5,558 samples. The study employed the OLS model for benchmark regression and multiple robust check methods, including altering variable settings and utilizing the instrumental variable model. In addition, the generalized structural equation model (GSEM) was used to analyze the mechanism.ResultUsing the internet was significantly associated with reduced depression in older adults (coefficient = −0.9321, p &lt; 0.001). The instrumental variable model confirmed this reduction (coefficient = −0.9200, p &lt; 0.001). Moreover, we found that there were three indirect pathways of Internet use on depression among older adults: the mediating role of volunteer activity participation (all p-values &lt;0.001), the mediating role of friend network (all p-values &lt;0.001), and the chain mediating role of both factors (all p-values &lt;0.001).ConclusionBased on the research findings, we suggest mobilizing tech-savvy older adults to assist others in adopting digital technology and using the internet. We also suggest that the government could assist in creating older adult-friendly communities. Social workers could collaborate with tech-savvy older adults to organize various voluntary activities, encouraging more senior citizens to participate. In addition, we recommend that the community should consider the form of activities to help older adults make friends first rather than solely focusing on voluntary activities.
Water Resources Management for Multi-Source Ecological Restoration Goals in an Oasis: A Case Study of Bohu County Irrigation Area in Xinjiang, China
Authors: Guo Chenyu , Liu Tie , Niu Yaxuan , Pan Xiaohui 
Published: September 2024

Oases in arid regions consist of river–lake–groundwater systems characterized by complex hydrological cycles and fragile ecosystems. Sustainable water resource management, aimed at multi-source ecological restoration, is crucial for oasis ecological protection and represents a current research challenge. This study focuses on the Bohu irrigation area, using ecological water levels, the MIKE-SHE hydrological model, and the water balance equation to propose a multi-objective groundwater and surface water regulation scheme that meets both the ecological safety requirements of the irrigation area and the ecological water demands of the Small Lake. Key findings include the following: (1) The regional ecological water level ranges from 1.69 m to 4 m, with about 74% of the area exceeding this range, threatening local ecology. (2) The proposed regulation method adjusts 91.25% of areas exceeding the ecological water level to within the acceptable range. (3) Under various planting scenarios, the minimum water distribution from the west branch of the BLSM water diversion hub should be 824.632 × 106 m3/a to meet Small Lake ecological demands. When this volume exceeds 831.902 × 106 m3/a, both groundwater regulation and Small Lake ecological demands are satisfied. This paper quantifies the water cycle mechanisms in complex hydrological interaction areas, providing specific solutions to regional ecological problems, which holds significant practical relevance.
Numerical methods for optimizing logistics systems in the process of inventory management
Authors: Chebotarev Stanislav S. , Khaitbaev Valery A. , Butchenko Viktor V. 
Published: September 2024

Scientists have always faced the task of evaluating the effectiveness of the functioning of complex systems, which unambiguously include logistics systems of transport (water, air, rail, automobile and their combinations) and stocks of products (goods), which (stocks of goods) are in static (warehouses) and dynamic (transport) states over time. A huge amount of theoretical material has been accumulated in this field of knowledge, which has been repeatedly tested and successfully applied, especially in relation to logistics systems. However, as is known, on the basis of an efficiency assessment, similar systems are compared, the operation of the systems is promptly evaluated, the system's compliance with its purpose is checked, the presence or absence of targeted targeting is found out, etc.
Hence, the relevance of the mathematical apparatus (numerical methods) for optimizing stocks of products (goods) is determined as a calculation for reasoned decision-making on effective inventory management using transport and storage capacities on an economic basis: the objective function is to minimize costs. Cost reduction in the processes of functioning of logistics systems due to the action of two basic laws – the law of saving time and the law of conservation of energy is one of the main modern directions for increasing their efficiency as complex systems [1-5].
Therefore, the optimization of logistics systems according to the criterion of costs (losses) in the processes of their functioning is defined as the formulation of the research task.
The aim of the work is to develop the application of numerical methods for optimizing logistics systems in the process of inventory management. The novelty consists in the application of numerical methods and the calculated ratios obtained, which can be used in the practice of the logistics system of water, air, rail and road transport for inventory management by optimizing the determined losses (costs).
The result consists in the developed method of studying theoretically calculated losses occurring in the processes of functioning of logistics systems of all types of transport and their combinations (hereinafter transport).
The theoretical significance of the results obtained is the development of the application of numerical methods for optimizing logistics systems in the process of inventory management, including: a set of factors and criteria for optimizing logistics processes; a method for modeling and optimizing the processes of functioning of logistics transport systems; a method for analyzing losses in the processes of functioning of logistics transport systems. These theoretical provisions make it possible to optimize the processes of functioning of logistics transport systems and, ultimately, to increase the efficiency of providing consumers, which is of important socio-economic importance.
Explicit estimates of the number of distinct prime divisors of binomial coefficients
Authors: Berkane Djamel , Sadaoui Boualem , Dusart Pierre 
Published: September 2024

UDC 511
We propose explicit estimates of the number of distinct prime divisors of a binomial coefficient through the explicit generalizations of some principal existing results. We also prove interesting number-theoretical propositions for the terms of a sequence of primes.
Mittag-Leffler stability and stabilization of some classes of time-varying fractional systems
Authors: Omri Faouzi 
Published: September 2024

UDC 517.9
We consider some classes of time-varying fractional systems and study the problem of stabilization for these systems with norm-bounded controls. We use time-varying Lyapunov functions to analyze the Mittag-Leffler stability of these systems. A numerical example is given to illustrate the efficiency of the obtained result.
A generalization for the kinematics of sliding-rolling motion in the semi-euclidean space

ℝ
ε
3
Authors: Şahin Tevfik , Orbay Keziban , Özdemir Zehra 
Published: September 2024

UDC 531
We propose a generalization for the sliding-rolling motion, which leads to meaningful physical and mathematical results as the general metric includes the time dimension. We also investigate the kinematics of the relative motion of two rigid objects, which maintain sliding-rolling contact, by using the general adjoint approach in the semi-Euclidean space

ℝ
ε
3

,

where

ε
∈

{
0,1
}

.

This generalization gives the geometric kinematic equations of the sliding-rolling motion in Minkowski and Euclidean spaces. In these spaces, we get a set of overconstrained equations. Solving this system, we determine translational and angular velocities of the moving surface.
Finally, we illustrate the results by two examples.
Spatial Variation of eDNA Detection Across an Invasion Gradient for Invasive Species Monitoring Programs
Authors: Peterman Laura , Tuttle-Lau Maren , DeHaan Patrick W. , Coulter David P. , Spear Stephen F. , Erickson Richard A. 
Published: September 2024

Abstract
Spatial and temporal distribution data provide critical information for invasive species management. For example, distribution data can help managers with early detection and to guide other response actions. Environmental DNA (eDNA)-based sampling exists as one tool for monitoring invasive species. As part of bigheaded carp Hypophthalmichthys spp. monitoring efforts in the Illinois River, United States, we compared eDNA-based sampling results at multiple habitats across an invasion gradient in 2015. Greater densities of carp occurred downriver in the Illinois River, and lower densities occurred upriver. We sampled from five locations along this gradient and from three habitat types (backwater, main channel, and shoreline) within each location. We sampled each location in April and June. A priori, we hypothesized that 1) more eDNA detections would occur downriver, where higher densities of carp occur, 2) more eDNA detections would occur in backwater habitats than in areas of the river with more fish movement, and 3) more eDNA detections would occur in April because bigheaded carps are thought to use our sampling areas more during the spring. We compared the proportion of samples positive across this gradient, the habitat type, and the two sampling time periods. The most downriver location had the highest proportion of samples with eDNA detections, the backwater habitats had the highest proportion of samples with eDNA detections, and April had more positive detections than June. Our results highlight the importance of sampling across multiple habitat types and across time to gain a clear understanding of distribution when using eDNA-based sampling. Thus, being cognizant of the interactions between seasonal habitat use and eDNA-based detections is important for managers who rely on eDNA-based monitoring.