bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes of Peritoneal Transport Parameters with Time on Dialysis: Assessment with Sequential Peritoneal Equilibration Test
Authors: Waniewski Jacek , Antosiewicz Stefan , Baczynski Daniel , Poleszczuk Jan , Pietribiasi Mauro , Lindholm Bengt , Wankowicz Zofia 
Published: July 2017

Background Sequential peritoneal equilibration test (sPET) is based on the consecutive performance of the peritoneal equilibration test (PET, 4-hour, glucose 2.27%) and the mini-PET (1-hour, glucose 3.86%), and the estimation of peritoneal transport parameters with the 2-pore model. It enables the assessment of the functional transport barrier for fluid and small solutes. The objective of this study was to check whether the estimated model parameters can serve as better and earlier indicators of the changes in the peritoneal transport characteristics than directly measured transport indices that depend on several transport processes. Methods 17 patients were examined using sPET twice with the interval of about 8 months (230 ± 60 days). Results There was no difference between the observational parameters measured in the 2 examinations. The indices for solute transport, but not net UF, were well correlated between the examinations. Among the estimated parameters, a significant decrease between the 2 examinations was found only for hydraulic permeability LpS, and osmotic conductance for glucose, whereas the other parameters remained unchanged. These fluid transport parameters did not correlate with D/P for creatinine, although the decrease in LpS values between the examinations was observed mostly for patients with low D/P for creatinine. Conclusions We conclude that changes in fluid transport parameters, hydraulic permeability and osmotic conductance for glucose, as assessed by the pore model, may precede the changes in small solute transport. The systematic assessment of fluid transport status needs specific clinical and mathematical tools beside the standard PET tests.
Relationship between clinical toxicities and ERCC1 rs3212986 and XRCC3 rs861539 polymorphisms in cervical cancer patients
Authors: Soares Sílvia , Nogueira Augusto , Coelho Ana , Assis Joana , Pereira Deolinda , Bravo Isabel , Medeiros Rui 
Published: July 2017

Background: Several studies have suggested that there are single nucleotide polymorphisms (SNPs) that can be considered potential biomarkers in the prognosis and therapeutic response of cancer patients. The present study investigated the association between ERCC1 rs3212986 and XRCC3 rs861539 polymorphisms and clinical toxicities induced by chemoradiotherapy (CRT) in cervical cancer. Methods: This hospital-based retrospective cohort study included 260 patients with cervical cancer, FIGO stages Ib2-IVa, who underwent CRT (cisplatin). Genetic polymorphisms analysis was performed by allelic discrimination with real-time polymerase chain reaction (RT-PCR). Results: Our results indicated a link between ERCC1 rs3212986 and the onset of late gastrointestinal toxicity (p = 0.038). Furthermore, using a recessive model (AA vs. CC/CA), we found that patients carrying AA homozygous genotype presented a fourfold increased risk of developing late gastrointestinal toxicity when compared with patients with the C allele (odds ratio = 3.727, 95% confidence interval, 1.199-11.588; p = 0.017). No association was found regarding the XRCC3 rs861539 polymorphism and any clinical toxicity event. Conclusions: This is the first study evaluating the relationship between these polymorphisms and clinical toxicities in cervical cancer patients submitted to CRT with cisplatin. These results may contribute toward a better understanding of the influence of genetic polymorphisms in genes associated with DNA repair in the clinical response to CRT of patients with cervical cancer.
IQGAP1 silencing suppresses the malignant characteristics of laryngeal squamous cell carcinoma cells
Authors: Wang Xiaoxia , He Chun , Li Chaohui , Ren Benhong , Deng Qing , Gao Wei , Wang Binquan 
Published: July 2017

Background: Laryngeal squamous cell carcinoma (LSCC) has a poor prognosis due to recurrence and metastasis. IQ-domain GTPase-activating protein 1 (IQGAP1), a scaffold protein, plays an important role in tumorigenesis and malignant development. In this study, we aimed to explore the role of IQGAP1 in LSCC. Methods: Expression of IQGAP1 in human LSCC specimens was assessed by immunohistochemistry. We also evaluated the roles of IQGAP1 in cell proliferation, migration and invasion and epithelial-to-mesenchymal transition (EMT) in Hep-2 cells. Results: The expression of IQGAP1 protein was significantly up-regulated in LSCC tissues compared with normal laryngeal tissues (p = 0.002). Furthermore, the knockdown of IQGAP1 in Hep-2 cells inhibited cell growth, migration and invasion. Moreover, we found that IQGAP1 silencing reversed EMT. Conclusions: These results show for the first time that IQGAP1 is up-regulated in LSCC tissues and plays an important role in LSCC cell proliferation and invasiveness, which indicates that IQGAP1 could work as an oncogene and may serve as a promising molecular target for treatment of LSCC.
Clinical Outcomes of Salvage Chemoradiotherapy for Locally Recurrent Biliary Tract Cancer
Authors: Yu Jeong Il , Park Hee Chul , Lim Do Hoon , Park Joon Oh , Park Young Suk , Kim Seung Tae , Choi Seong Ho , Choi Dong Wook , Han In Woong , Heo Jin Seok 
Published: July 2017

Purpose The purpose of this study was to investigate the clinical outcomes and prognostic factors of concurrent chemoradiotherapy (CCRT) for locally recurrent biliary tract cancer (BTC) after curative surgical resection. Methods We performed a retrospective cohort study of patients with locally recurrent BTC treated with CCRT between October 2004 and December 2013. The study included and analyzed 42 patients with a history of curative-intent surgical resection of confirmed adenocarcinoma originating from the biliary tract. Results The median time to recurrence after surgery was 16.1 months (range, 4.5-77.8 months). Median follow-up after CCRT was 26.9 months (range, 5.2-81.9) with no grade 3 or higher gastrointestinal toxicities. Analysis of the first site of failure showed local progression (LP) developed in 20 patients (47.6%); among these, 16 (38.1%) had isolated LP. The median values were 15.8 months (range, 1.7-81.7) for LP-free survival (LPFS), 10.6 months (range, 1.7 - 81.7) for progression-free survival (PFS) and 41.2 months (range, 5.2-81.9) for overall survival (OS). Multivariate analysis showed that the level of pre-CCRT carbohydrate antigen (CA) 19-9 and the chemotherapy regimen were significant prognostic factors for LPFS and PFS; pT stage was the only significant prognostic factor for OS. Conclusions CCRT for locally recurrent BTC showed promising outcomes as a salvage modality, but LP was still frequent. The pre-CCRT CA 19-9 level and the chemotherapy regimen were prognostic factors for LPFS and PFS.
Clinical and Subclinical Cardiac Late Effects in Pediatric Hodgkin's Lymphoma Survivors
Authors: Materazzo Carlo , Massimino Maura , Schiavello Elisabetta , Podda Marta , Gandola Lorenza , Cefalo Graziella , Catania Serena , Meazza Cristina , Moschetti Ivan , Terenziani Monica 
Published: July 2017

Purpose Cardiac late effects are responsible for a significant burden of mortality and morbidity among pediatric Hodgkin's lymphoma (HL) survivors (HLS). The aim of our study was to assess clinical and subclinical cardiac sequelae in a cohort of childhood HLS treated in the 1980s with doxorubicin, bleomycin, vinblastine, and dacarbazine (the ABVD regimen) and limited-field radiotherapy (RT). Methods We retrospectively examined a series of HLS treated from 1979 to 1989. We searched for subtle cardiac abnormalities in a subgroup of asymptomatic individuals, who underwent rest and exercise echocardiography at least 20 years after completing their therapies. Their cardiac assessment included physical examination, electrocardiogram (ECG), and resting and postexercise echocardiograms. Results On thorough cardiac assessment a mean of 21 years after their diagnosis, none of the 53 unselected asymptomatic HLS showed physical signs or significant ECG abnormalities during or after the stress echo test. Twenty-two (41%) of the 53 patients revealed valvular abnormalities, with mitral regurgitation in 28%, aortic regurgitation in 9%, and both in 4%. No significant myocardial dysfunction as a result of previous combined doxorubicin treatment and chest RT was identified. Only 2 individuals had mild pericardial alterations. Conclusions The present study shows that long-term cardiac effects are common in HLS treated with the ABVD regimen and RT. The most frequent complications observed in this sample were essentially coronary artery disease and valvular abnormalities. None of the survivors in this sample showed overt congestive heart failure, a finding in contrast with larger studies.
Short Course Radiotherapy Concomitant with Temozolomide in GBM Patients: A Phase II Study
Authors: Fariselli Laura , Cuppini Lucia , Gaviani Paola , Marchetti Marcello , Pinzi Valentina , Milanesi Ida , Simonetti Giorgia , Tramacere Irene , DiMeco Francesco , Salmaggi Andrea , Silvani Antonio 
Published: July 2017

Purpose Despite recent advances, the prognosis of glioblastoma (GBM) remains poor. The aim of this study was to assess the efficacy and tolerability of multiple daily fraction radiotherapy performed with multiple temozolomide (TMZ) administrations in newly diagnosed patients with GBM. Methods This trial was a prospective, open-label, monocentric, nonrandomized, single arm, phase II study. The primary endpoint was the proportion of progression-free patients at 12 months, and the secondary endpoints were overall survival (OS) and toxicity. Thirty-five patients underwent two radiotherapy courses concomitant with TMZ after surgery. At each course, radiation was delivered 3 times daily, 2 Gy/fraction, for 5 consecutive days, and the total dose was 60 Gy; concurrent TMZ was administered in a total dose of 150-200 mg/m2/day. Results The primary endpoint failed to be applied; Macdonald criteria could be used in 16 (46%) patients with local or intracerebral recurrence (group A). In 12 patients, due to suspicion of radiation necrosis vs recurrence, Macdonald criteria were not applied (group B). The OS was 22 months, and OS probabilities at 12, 18, and 24 months were 82%, 59%, and 44%, respectively. Hematologic toxicities generally did not exceed grade 2. The quality of life and cognitive functioning did not significantly change between baseline and the first follow-up. In the multivariate analysis, necrosis and pseudoprogression were significant prognostic factors of OS. Conclusions To improve local control and OS, a more aggressive treatment schedule should be explored. The related higher necrosis risk and its implications regarding local control deserve further investigation.
Experience after 12 Cases with the Adjustable Transobturator Male Sling for Postprostatectomy Stress Urinary Incontinence
Authors: Vismara Fugini Andrea , Giovanessi Luca , Tosana Michelangelo 
Published: July 2017

Objectives The aim of the study was the prospective evaluation of the efficacy of the adjustable transobturator male system (ArgusT®) for the treatment of postprostatectomy stress urinary incontinence (PPI). Methods Twelve consecutive patients were treated with ArgusT system for PPI. All patients were comprehensively evaluated preoperatively and after 3 and 6 months regarding daily pad use, residual urine, Incontinence Quality of Life Scale (I-QoL) score and International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF) score. Cure rate was defined as no pad use or one pad (used for security reasons). Results At 3 and 6 months, we achieved a cure rate of 91%. The mean number of pads per day decreased from 4 ± 1.3 to 0.7 ± 0.9 and 0.5 ± 0.9 after 3 and 6 months, respectively (p<0.001). Only one patient showed no significant improvement. Compared with baseline, the mean ICIQ-SF score dropped from 17.3 ± 2.8 to 2.7 ± 3.8 and 2.4 ± 3.8, at 3 and 6 months, respectively (p<0.001). The mean I-QoL score also improved significantly from 53.1 ± 20.3 to 99.5 ± 11 and 96.8 ± 12.5 after 3 and 6 months, respectively (p<0.001). Postoperative acute urinary retention was seen in one patient. Conclusions In our early experience, the ArgusT system offers effective, safe and minimally invasive treatment option for PPI.
Reading Like a Jew: Chaucer's Physician's Tale and the Letter of the Law
Authors: Seal Samantha Katz 
Published: July 2017

Abstract
Drawing from medieval Christian depictions of Jewish literalism and materialist reading, this article offers a reevaluation of Chaucer's Physician and his tale's protagonist Virginius, as men who read like Jews, even though they remain distinct from the racialized characterization of the Prioress's Tale. This article argues that Chaucer depicts “reading Jewishly” as an intellectual flaw, one into which Christian and pagan men might fall, with tragic results for themselves, but potentially edifying ones for those who witness their failures of perception. The Physician's Tale is thus to be read as a narrative of conversion, and it concerns the conflict between a literalist “Jewish” hermeneutic and a figural Christian epistemology premised on faith.
Retention Models on Core–Shell Columns
Authors: Jandera Pavel , Hájek Tomáš , Růžičková Marie 
Published: July 2017

Abstract
A thin, active shell layer on core–shell columns provides high efficiency in HPLC at moderately high pressures. We revisited three models of mobile phase effects on retention for core–shell columns in mixed aqueous–organic mobile phases: linear solvent strength and Snyder–Soczewiński two-parameter models and a three-parameter model. For some compounds, two-parameter models show minor deviations from linearity due to neglect of possible minor retention in pure weak solvent, which is compensated for in the three-parameter model, which does not explicitly assume either the adsorption or the partition retention mechanism in normal- or reversed-phase systems. The model retention equation can be formulated as a function of solute retention factors of nonionic compounds in pure organic solvent and in pure water (or aqueous buffer) and of the volume fraction of an either aqueous or organic solvent component in a two-component mobile phase. With core–shell columns, the impervious solid core does not participate in the retention process. Hence, the thermodynamic retention factors, defined as the ratio of the mass of the analyte mass contained in the stationary phase to its mass in the mobile phase in the column, should not include the particle core volume. The values of the thermodynamic factors are lower than the retention factors determined using a convention including the inert core in the stationary phase. However, both conventions produce correct results if consistently used to predict the effects of changing mobile phase composition on retention. We compared three types of core–shell columns with C18-, phenyl-hexyl-, and biphenyl-bonded phases. The core–shell columns with phenyl-hexyl- and biphenyl-bonded ligands provided lower errors in two-parameter model predictions for alkylbenzenes, phenolic acids, and flavonoid compounds in comparison with C18-bonded ligands.
Uma breve análise da intervenção estatal brasileira à luz do Programa Minha Casa Minha Vida (PMCMV)
Authors: Medrado Maria José Celestino 
Published: July 2017

<p>Este trabalho realizou uma breve análise bibliográfico-documental sobre a intervenção do estado no atual programa nacional de habitação – o Minha Casa Minha Vida. Para isso, priorizou-se o período de 2009 a 2014, focalizando as ações destinadas a famílias com até três salários mínimos. Foi constatado que o Programa Minha Casa Minha Vida apresenta significante valor mercadológico, pois foi implementado em um setor de grande importância para a geração de renda e emprego. No entanto, os resultados alcançados com o programa em relação aos indicadores de avaliação de desempenho, a saber, Economicidade, Eficiência, Eficácia e Efetividade, são insatisfatórios, pois não apresentam simetria com o bem-estar social dos beneficiários ou com aspectos ambientais, além de apresentar disparidade entre os gastos governamentais destinados ao programa. Nesse sentido, o referido programa favoreceu o mercado interno, o setor de construção civil e os aspectos político-partidários. Em contrapartida, favoreceu a exclusão social, deixando à margem indivíduos que apresentam baixo nível socioeconômico, além de inobservar ações voltadas para os aspectos ambientais de conservação e preservação. </p>
AUDIÊNCIA DE CUSTÓDIA: Uma análise sob o prisma da Resolução 213 do CNJ.
Authors: Teixeira Leandro , Rios Marcos Roberto da Silva 
Published: July 2017

O presente trabalho trata da audiência de custódia, nos termos da Resolução 213 do CNJ, e sua implementação no Brasil. A metodologia utilizada foi a revisão bibliográfica que vale-se de fontes primárias e secundárias, através da análise de manuais doutrinários, artigos e legislação pertinente ao tema. O trabalho apresentado é uma dissertação acerca da audiência de custódia, seus procedimentos a serem seguidos no intuito de garantir a preservação dos direitos fundamentais da pessoa presa, os participantes que a integram e suas finalidades a serem atingidas com a implementação no território pátrio. A audiência de custódia também buscou adequar o processo penal aos tratados internacionais de direitos humanos, uma vez que, por serem normas definidoras de direitos e garantias fundamentais, referidos pactos têm aplicação imediata no território brasileiro. Finalizado o trabalho, foi possível concluir que a audiência de custódia trouxe avanços significativos no tocante à preservação dos direitos da pessoa presa, em suma, redução da prática de tortura, bem como a diminuição da população carcerária à espera de julgamento.
Skidt med årsagen, når bare vi er pålidelige. Psykiatriske diagnosers historiske indhold, udvikling og funktion
Authors: Ringø Pia 
Published: July 2017

Hvad er det videnskabelige indhold i de psykiatriske diagnosesystemer? På hvilken måde har psykiatriske diagnoser en eksemplarisk relevans, der afspejler mere grundlæggende økonomiske, politiske og samfundsmæssige transformationsprocesser, og hvad kan vi lære af fortiden? Hvorfor handler uenigheder vedrørende de psykiatriske diagnoser dels om, hvad der bør kendetegne ”god” eller ”rigtig og sand” viden, men også om moral, værdier og menneske- og samfundssyn? Det er nogle af de spørgsmål, artiklen søger svar på. I artiklen vises, gennem en historisk analyse, hvorledes psykiatriske diagnoser afspejler grundlæggende bevægelser i viden om, og synet på, menneske, samfund og sygdom. Don’t mind the causes, just be reliable: The historical content, development, and function of psychiatric diagnosesHow do shifting psychiatric diagnoses reflect our understanding of humanity and of human problems, illnesses, and unwanted conditions? In what way do psychiatric diagnoses hold an exemplary relevance that transcends the object of research of psychiatry and reflects more fundamental econom- 58 Tidsskrift for Forskning i Sygdom og Samfund, nr. 25, 57-72 ic, political, and societal transformation processes, and what can we learn from the past? Why are disagreements concerning psychiatric diagnoses partially about what ought to characterize “good” or “real and true” knowledge, but also about morals, values, and views on society and human nature? These are some of the questions that the article seeks to answer. Through a historical analysis, the article illustrates how psychiatric diagnoses reflect shifting views on society and human nature in a close welfare political and economic interaction.
LA JUSTICIA MEDIOAMBIENTAL COMO NUEVO PARADIGMA
Authors: Bas Soria José Juan 
Published: July 2017

Resumen. La justicia medioambiental como nueva forma de enfocar los problemas medioambientales representa una opción todavía inexplorada en el espacio europeo. En su origen estuvo centrada en una temática específicamente estadounidense: el grado de participación de las minorías negra e hispana en lar cargas y beneficios medioambientales, acuñando los conceptos de “injusticia medioambiental” y de “racismo medioambiental”. Sin embargo, hoy en día representa un nuevo modo de “medir” los impactos medioambientales y este artículo propone un acercamiento al concepto de la justicia medioambiental, analizando sus elementos más característicos, así como los argumentos críticos que se han esgrimido, aportando las bases para un debate científico.

Palabras clave: Medio ambiente y desarrollo; justicia; gobierno; políticas públicas.

Abstract. Environmental justice as a new approach to environmental questions constitutes a non-explored option in the European scope. It was originally focused on American topics (the fair distribution of environmental charges and benefits, especially as concerns to black and latino communities), coining the concept of “environmental injustice” and “environmental racism”. Nonetheless, at the present time, it represents a new way of measuring environmental impacts. So, this article provides an approach to environmental justice, an analysis of its most characteristic features and an exam of its critical arguments, offering new grounds to the scientific debate.

Key words: Environment and development; justice; government policy.
IMMIGRACIÓN Y POLÍTICAS DE PARTICIPACIÓN EN EL ÁREA METROPOLITANA DE VALENCIA
Authors: Kruithof Ausina Andrea 
Published: July 2017

Resumen. El objetivo de este proyecto de investigación es identificar los mecanismos de participación disponibles para la comunidad de extranjeros asentada en la ciudad de Valencia. Una breve introducción y descripción de los conceptos utilizados será seguida del análisis de la regulación local, principalmente los Planes de Integración valencianos, así como los organismos derivados de ella. La segunda fase presenta un análisis crítico de la situación, mostrando los puntos fuertes y débiles de las políticas de participación dirigidas a los inmigrantes. Este artículo intentará demostrar que el resultado de estas políticas no se corresponde con las intenciones de Planes, sugiriendo que no ha sido una prioridad para las autoridades públicas. Finalmente, se presentarán recomendaciones para el futuro, apostando por una mayor inclusión de los recién llegados en la vida pública.

Palabras clave: políticas públicas, integración, participación cívica y política.

Abstract. The purpose of this research paper is to identify the existing mechanisms of participation for the foreign community established in Valencia (Spain). A brief introduction and description of the main concepts used will be followed by the analysis of the local regulation, mainly Valencia's Integration Plans, as well as those organisms created by them. The second phase will present a critical analysis of the situation, showing the strengths and weaknesses of the policies that address the participation of immigrants. This article will try to prove that the outcome of these policies doesn't fit well with the intentions declared in the Plans, proving that it hasn't been a priority for the public authorities. Finally, some recommendations for the future will be presented, taking chance for a larger involvement of the newcomers in public life.

Key words: public politics, integration, civic and political participation.