bluuebunny/crossref_metadata_2025_split huggingface dataset:
The in vivo efficacy of neuraminidase inhibitors cannot be determined from the decay rates of influenza viral titers observed in treated patients
Authors: Palmer John , Dobrovolny Hana M. , Beauchemin Catherine A. A. 
Published: January 2017

AbstractAntiviral therapy is a first line of defence against new influenza strains. Current pandemic preparations involve stock- piling oseltamivir, an oral neuraminidase inhibitor (NAI), so rapidly determining the effectiveness of NAIs against new viral strains is vital for deciding how to use the stockpile. Previous studies have shown that it is possible to extract the drug efficacy of antivirals from the viral decay rate of chronic infections. In the present work, we use a nonlinear mathematical model representing the course of an influenza infection to explore the possibility of extracting NAI drug efficacy using only the observed viral titer decay rates seen in patients. We first show that the effect of a time-varying antiviral concentration can be accurately approximated by a constant efficacy. We derive a relationship relating the true treatment dose and time elapsed between doses to the constant drug dose required to approximate the time- varying dose. Unfortunately, even with the simplification of a constant drug efficacy, we show that the viral decay rate depends not just on drug efficacy, but also on several viral infection parameters, such as infection and production rate, so that it is not possible to extract drug efficacy from viral decay rate alone.
Photonic crystal nanocavity assisted rejection ratio tunable notch microwave photonic filter
Authors: Long Yun , Xia Jinsong , Zhang Yong , Dong Jianji , Wang Jian 
Published: January 2017

AbstractDriven by the increasing demand on handing microwave signals with compact device, low power consumption, high efficiency and high reliability, it is highly desired to generate, distribute, and process microwave signals using photonic integrated circuits. Silicon photonics offers a promising platform facilitating ultracompact microwave photonic signal processing assisted by silicon nanophotonic devices. In this paper, we propose, theoretically analyze and experimentally demonstrate a simple scheme to realize ultracompact rejection ratio tunable notch microwave photonic filter (MPF) based on a silicon photonic crystal (PhC) nanocavity with fixed extinction ratio. Using a conventional modulation scheme with only a single phase modulator (PM), the rejection ratio of the presented MPF can be tuned from about 10 dB to beyond 60 dB. Moreover, the central frequency tunable operation in the high rejection ratio region is also demonstrated in the experiment.
Widespread temporo-occipital lobe dysfunction in amyotrophic lateral sclerosis
Authors: Loewe Kristian , Machts Judith , Kaufmann Jörn , Petri Susanne , Heinze Hans-Jochen , Borgelt Christian , Harris Joseph Allen , Vielhaber Stefan , Schoenfeld Mircea Ariel 
Published: January 2017

AbstractRecent studies suggest that amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) lie on a single clinical continuum. However, previous neuroimaging studies have found only limited involvement of temporal lobe regions in ALS. To better delineate possible temporal lobe involvement in ALS, the present study aimed to examine changes in functional connectivity across the whole brain, particularly with regard to extra-motor regions, in a group of 64 non-demented ALS patients and 38 healthy controls. To assess between-group differences in connectivity, we computed edge-level statistics across subject-specific graphs derived from resting-state functional MRI data. In addition to expected ALS-related decreases in functional connectivity in motor-related areas, we observed extensive changes in connectivity across the temporo-occipital cortex. Although ALS patients with comorbid FTD were deliberately excluded from this study, the pattern of connectivity alterations closely resembles patterns of cerebral degeneration typically seen in FTD. This evidence for subclinical temporal dysfunction supports the idea of a common pathology in ALS and FTD.
Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study
Authors: Funayama Takashi , Tamura Yoshifumi , Takeno Kageumi , Kawaguchi Minako , Kakehi Saori , Watanabe Takahiro , Furukawa Yasuhiko , Kaga Hideyoshi , Yamamoto Risako , Kanazawa Akio , Fujitani Yoshio , Kawamori Ryuzo , Watada Hirotaka 
Published: January 2017

AbstractIt has been demonstrated that moderate alcohol consumption provides protection against the development of type 2 diabetes. However, several other reports suggested that moderate alcohol intake may increase the risk of type 2 diabetes in non-obese Japanese. The aim of present study was to investigate the effect of 1-week alcohol abstinence on hepatic insulin sensitivity and fasting plasma glucose (FPG) in non-obese Japanese men. We recruited 8 non-obese Japanese men with mildly elevated FPG and drinking habits alcohol (mean frequency; 5.6 ± 2.5 times/week, mean alcohol consumption; 32.1 ± 20.0 g/day). Before and after the 1-week alcohol abstinence, we used the 2-step hyperinsulinemic-euglycemic clamp to measure endogenous glucose production (EGP) and insulin sensitivity (IS) in muscle and liver. One-week alcohol abstinence significantly reduced both FPG by 7% (from 105.5 ± 11.7 to 98.2 ± 7.8 mg/dl, P < 0.01) and fasting EGP by 6% (from 84.1 ± 4.2 to 77.6 ± 1.6 mg/m2 per min, P < 0.01), respectively. Two–step clamp study showed that alcohol abstinence significantly improved hepatic-IS, but not muscle-IS. In conclusion, one week alcohol abstinence improved hepatic IS and FPG in non-obese Japanese men with mildly elevated FPG and drinking habits alcohol.
Residential exposure to chlorinated hydrocarbons from groundwater contamination and the impairment of renal function-An ecological study
Authors: Chen Hui-Ming , Wu Ming-Tsang 
Published: January 2017

AbstractGroundwater pollution from the petrochemical industry causes serious deterioration of soil and groundwater quality and impacts on human health worldwide. However, few studies have examined the effect of residential exposure to petrochemical chlorinated hydrocarbon-contaminated groundwater on renal function impairment in humans. We conducted an ecological study to investigate the two. A polyvinyl chloride (PVC) plant was located in one of the six villages, the study area, in Kaohsiung city of southwestern Taiwan. Based on the direction of groundwater flow and previous groundwater measurements of chlorinated hydrocarbons from Taiwan Environmental Protection Bureau, we divided the six villages into highly-polluted villages, moderately-polluted villages, and a non-polluted village. All inhabitants in those six villages were invited to receive free health examinations between May-June, 2010. In total, 4,432 study subjects ≥18 yrs old were analyzed. Compared to those in the non-polluted village, subjects in highly-polluted villages had 1.89- and 1.46-fold the risk of impaired estimated glomerular filtration rate (eGFR) and proteinuria (95% CI = 1.15–1.85 and 1.09–3.28, respectively) after adjusting for other covariates. Given this relative large sample size, we found that groundwater chlorinated hydrocarbon pollution can cause kidney damage in adults.
Topography-associated thermal gradient predicts warming effects on woody plant structural diversity in a subtropical forest
Authors: He Siyan , Zhong Yonglin , Sun Yudan , Su Zhiyao , Jia Xiaorong , Hu Yanqiu , Zhou Qing 
Published: January 2017

AbstractUnderstanding global warming effects on forest ecosystems will help policy-makers and forest managers design forest management and biodiversity conservation strategies. We examined the change in woody plant structural diversity in response to topography-associated thermal gradients in a subtropical forest with diverse abundance patterns. We found that energy distribution in a warming trend across slopes had significant effects on woody plant structural diversity. Except for total basal area of the adult trees, plant structural diversity significantly decreased with the increase of heat load. Heat load is significantly and negatively correlated with number of stems, number of species, and the number of stems of the most abundant species (Nmax) for seedlings, saplings, and individuals of all sizes. For the adult trees, heat load is significantly and positively correlated with number of stems and Nmax, and negatively but not significantly with number of species, indicating that large trees may not be as sensitive as seedlings and saplings to warming. Partial correlation analysis, having controlled for elevation, strengthened those relations in most cases. Our results reveal that warming will increase community productivity by enhancing the growth of large trees, but decrease species diversity and inhibit the regeneration of tree seedlings and saplings.
Strong, ductile, and thermally stable Cu-based metal-intermetallic nanostructured composites
Authors: Dusoe Keith J. , Vijayan Sriram , Bissell Thomas R. , Chen Jie , Morley Jack E. , Valencia Leopolodo , Dongare Avinash M. , Aindow Mark , Lee Seok-Woo 
Published: January 2017

AbstractBulk metallic glasses (BMGs) and nanocrystalline metals (NMs) have been extensively investigated due to their superior strengths and elastic limits. Despite these excellent mechanical properties, low ductility at room temperature and poor microstructural stability at elevated temperatures often limit their practical applications. Thus, there is a need for a metallic material system that can overcome these performance limits of BMGs and NMs. Here, we present novel Cu-based metal-intermetallic nanostructured composites (MINCs), which exhibit high ultimate compressive strengths (over 2 GPa), high compressive failure strain (over 20%), and superior microstructural stability even at temperatures above the glass transition temperature of Cu-based BMGs. Rapid solidification produces a unique ultra-fine microstructure that contains a large volume fraction of Cu5Zr superlattice intermetallic compound; this contributes to the high strength and superior thermal stability. Mechanical and microstructural characterizations reveal that substantial accumulation of phase boundary sliding at metal/intermetallic interfaces accounts for the extensive ductility observed.
Impact of a Type D Personality on Clinical and Psychometric Properties in a Sample of Turkish Patients With a First Myocardial Infarction
Authors: ANNAGÜR BILGE B. , DEMIR KENAN , AVCI AHMET , UYGUR ÖMER FARUK 
Published: January 2017

Background:
Recent studies have shown that a Type D personality is associated with an increased risk of cardiac mortality.

Objective:
This study aimed to examine the impact of a Type D personality on clinical and psychometric properties in a sample of Turkish patients with a first myocardial infarction (MI).

Method:
The study included 131 patients who were admitted to the coronary care unit of a hospital. All of the patients underwent a psychiatric assessment within 2 to 6 months after their MI. Psychiatric interviews were conducted using the Structured Clinical Interview for DSM-IV (SCID-I). Patients also completed the Beck Depression Inventory, the Spielberger State-Trait Anxiety Inventory, the Health Anxiety Inventory, and the Type D personality scale.

Results:
The patients were divided into 2 groups on the basis of the presence or absence of Type D personality. There was a 38.2% prevalence of Type D personality in the patients with a first MI. Those with this type of personality had a significantly higher frequency of hypertension and stressful life events. The Type D patients also had more psychiatric disorders, including depressive and anxiety disorders, than the non-Type D patients.

Conclusions:
Our findings suggest that Type D personality traits may increase the risk of hypertension and the risk of psychiatric morbidity in patients with a first MI. We suggest that this type of personality is a contributor to depression and anxiety disorders. These findings emphasize the importance of screening for Type D personality as both a cardiovascular and psychiatric risk marker in patients who have had an MI.
Saccadic suppression as a perceptual consequence of efficient sensorimotor estimation
Authors: Crevecoeur F. , Kording K. P. 
Published: January 2017

AbstractHumans perform saccadic eye movements two to three times per second. When doing so, the nervous system strongly suppresses sensory feedback for extended periods of time in comparison with the movement time. Why does the brain discard so much visual information? Here we suggest that perceptual suppression may arise from efficient sensorimotor computations, assuming that perception and control are fundamentally linked. More precisely, we show that a Bayesian estimator should reduce the weight of sensory information around the time of saccades, as a result of signal dependent noise and of sensorimotor delays. Such reduction parallels the behavioral suppression occurring prior to and during saccades, and the reduction in neural responses to visual stimuli observed across the visual hierarchy. We suggest that saccadic suppression originates from efficient sensorimotor processing, indicating that the brain shares neural resources for perception and control.
Robust prediction of CO2 corrosion rate in extraction and production hydrocarbon industry
Authors: Hosseini Seyed Mohammad Kazem 
Published: January 2017

Purpose
CO2 corrosion rate prediction is regarded as the backbone of materials selection in upstream hydrocarbon industry. This study aims to identify common types of errors in CO2 rate calculation and to give guidelines on how to avoid them.

Design/methodology/approach
For the purpose of this study, 15 different “corrosion study and materials selection reports” carried out previously in upstream hydrocarbon industry were selected, and their predicted CO2 corrosion rates were evaluated using various corrosion models. Errors captured in the original materials selection reports were categorized based on their type and nature.

Findings
The errors identified in the present study are classified into the following four main types: using inadequate or false data as the input to the model, failing to address factors which may have significant influence on corrosion rate, utilizing corrosion models beyond their validity range and utilizing a corrosion model for a specific set of input, where the model is considered to be inaccurate even though the input lies within the software’s range of validity.

Research limitations/implications
This study is mainly based on the use of various corrosion models, and except few cases for which some actual field corrosion monitoring data were available, no laboratory tests were performed to verify the predicted data.

Practical implications
The paper provides a checklist of common types of errors in CO2 corrosion rate prediction and the guidelines on how to avoid them.

Originality/value
CO2 corrosion rate calculation is regarded as the backbone of materials selection in hydrocarbon industry. In this work, the source of errors in terms of corrosion modeling tool and human factors were identified.
Micro and small business innovation in a traditional industry
Authors: Duarte Alonso Abel , Bressan Alessandro 
Published: January 2017

Purpose
The purpose of this paper is to explore innovation among micro and small business operators in Italy’s wine industry. Moreover, in adopting the theory of innovation, the study examines winery operators’ perceptions on innovation, ways in which wineries are innovating and whether participants’ responses vary based on demographic characteristics.

Design/methodology/approach
An online questionnaire designed for this study gathered the responses of 211 participants, composed by owners, winemakers, directors and business partners.

Findings
Innovation is fundamentally associated with minimising ecological footprint, investments, making improvements in the winery, adapting to trends and new consumer demands and, importantly, with maintaining traditions while enhancing the quality of the wines. Further, participants primarily agree with involvement in wine tourism and adoption of social media as predominant forms of innovating. Several inter-group differences particularly based on levels of wine production and size of the winery emerged. Overall, the findings align with the dimensions of the theory of innovation, namely, benefits, costs, resources and discounting factors.

Originality/value
Despite the significance of Italy’s wine industry, in terms of exports and consumption on a global scale, academic research focusing on this industry’s innovative practices has been limited. Similarly, there is scant research on innovation among micro and small firms, or on industries relevant to countries’ socio-economic capital. This exploratory study provides an element of originality and value, exploring and contributing to the literature on these under-researched areas.
An innovative approach to mitigating horizon mismatch
Authors: Chakrabarty Anindya , Dubey Rameshwar , De Anupam 
Published: January 2017

Purpose
This paper aims to propose an innovative approach to risk measurement for the abolition of selection bias arising from the specious selection of different horizons for investment and risk computation of equity-linked-saving schemes (ELSS).

Design/methodology/approach
ELSS has a lock-in period of three years, but shorter horizons’ (daily/weekly/monthly) return data are preferred, in practice, for risk computation. This results in horizon mismatch. This paper studies the consequences of this mismatch and provides a noble solution to diminish its effect on investors’ decision-making. To accomplish this objective, the paper uses an innovative methodology, maximal overlap discrete wavelet transformation, to segregate the price movements across different horizons. Risk across all horizons is measured using Cornish-Fisher expected shortfall and Cornish-Fisher value-at-risk methods.

Findings
The degree of consistency of risk-based rankings across horizons is examined by means of the Spearman and Kendall’s rank correlation tests. The risk-based ranking of ELSS is found to vary significantly with the change in investor’s horizon. Precisely, the rankings formulated using daily net asset values are significantly different from the rankings developed using fluctuations over longer horizons (two-four and four-eight years).

Originality/value
This finding indicates that the ranking exercise may mislead investors if horizon correction is not done while developing such rankings.
Analysis of co-generation combustion chamber inlet line
Authors: Eldho Shibu Melvin , K.S. Jithish 
Published: January 2017

Purpose
The catastrophic failures of these thick-wall cylinders are mainly due to the presence of inherent cracks in the material. The present study aims to deal with the analysis of stress for a given range of inside pressure. The paper deals with the calculation of radial and tangential stresses for various external pressure-to-internal pressure ratios and external radius to internal radius of the thick-walled cylinder.

Design/methodology/approach
The inlet line to the combustion chamber normally has an internal diameter of 150 mm and has a thickness of 25 mm. Normal temperature of the working fluid is about 80°C and the outside temperature is kept as room temperature. The present work deals with the stress analysis of the inlet line with and without internal crack. Also the stress intensity factors are calculated to check with the fracture toughness. Analysis is done both theoretically and by FEM by using the well-known software ANSYS.

Findings
Results show that the radial stress is independent of the external radius-to-internal radius ratio, while the tangential stress increases.

Practical implications
In process industries like nuclear or chemical, etc., structures in the form of thick-walled cylinders play a vital role, as its failure can affect humans and the environment. Because of this, the design and analysis of the above cylinders are of much significance.

Originality/value
Due to constant or cyclic operating pressure of pressure vessels and its corresponding pipelines usually in the form of thick-walled cylinders, reliability of the materials and structures used is of critical importance, as its failure can be deadly and possess lethal dangers when the cylinder contains flammable, toxic or reactive working fluid. The major ruling factors for the failure are none other than stress-related defects and presence of cracks.
Research on architecture of security video surveillance network cascade system with big data
Authors: Li Zhihua , Tang Zianfei , Yang Yihua 
Published: January 2017

Purpose
The high-efficient processing of mass data is a primary issue in building and maintaining security video surveillance system. This paper aims to focus on the architecture of security video surveillance system, which was based on Hadoop parallel processing technology in big data environment.

Design/methodology/approach
A hardware framework of security video surveillance network cascaded system (SVSNCS) was constructed on the basis of Internet of Things, network cascade technology and Hadoop platform. Then, the architecture model of SVSNCS was proposed using the Hadoop and big data processing platform.

Findings
Finally, we suggested the procedure of video processing according to the cascade network characteristics.

Originality/value
Our paper, which focused on the architecture of security video surveillance system in big data environment on the basis of Hadoop parallel processing technology, provided high-quality video surveillance services for security area.
Impact of integrated HSE management system on power generation in Iran by a unique mathematical programming approach
Authors: Azadeh A. , Motevali Haghighi S. , Hosseinabadi Farahani M. , Yazdanparast R. 
Published: January 2017

Purpose
Concern for health, safety and environment (HSE) is increasing in many developing countries, especially in energy industries. Improving power plants efficiencies in terms of HSE issues requires considering these issues in performance assessment of power generation units. This study aims to discuss the use of data envelopment analysis methodology for the performance assessment of electrical power plants in Iran by considering HSE and conventional indicators.

Design/methodology/approach
Installed capacity, fuel consumption, labor cost, internal power, forced outage hours, operating hours and total power generation along with HSE indices are taken into consideration for determining the efficiency of 20 electric power plants or decision-making units (DMUs). Moreover, DMUs are ranked based on their relative efficiency scores.

Findings
Results show that HSE factors are significant in performance assessment of the power plants studied in this research, and among HSE factors, health has the most powerful impact on the efficiency of the power plants.

Originality/value
The approach of this study could be used for continuous improvement of combined HSE and conventional factors. It would also help managers to have better comprehension of key shaping factors in terms of HSE.