bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of migraine interictal burden: The hidden role of subjective memory complaints
Authors: Sotero Filipa Dourado , Nobre João , Vicente Beatriz Nunes , Martins Isabel Pavão 
Published: September 2024

AbstractBackgroundThe “interictal burden of migraine” (MIB) is a new concept that encompasses the overall impact of the disease between migraine episodes. However, the factors that contribute to this interictal burden are still unclear.ObjectiveThis study aimed to identify explanatory factors of interictal burden in patients with migraine.MethodsThis prospective cross‐sectional observational including 200 patients with migraine (92% [n = 184] female, with a mean [standard deviation] age of 44.8 [12] years, 53% [n = 106] with chronic migraine) completed a clinical and questionnaire assessment targeting MIB, migraine impact, and depressive and cognitive complaints.ResultsMore than three‐fourths (76% [n = 152]) of patients had moderate‐to‐severe interictal burden. Higher interictal burden (MIB Scale ≥2) was associated with higher headache frequency (eight vs. 14, p = 0.001) and intensity (headache index score 17.0 vs. 30.0, p = 0.002), higher headache impact (six‐item Headache Impact Test score 59.2 vs. 63.9, p = 0.001), and more subjective memory complaints (Subjective Memory Complaints Questionnaire [SMC] score 9.0 vs. 4.5, p = 0.001), as well as anxiety (Hospital Anxiety and Depression Scale (HADS)‐Anxiety score 5 vs. 10, p < 0.001) and depression symptoms (HADS‐Depression score 5 vs. 8, p < 0.001). Once accounted for these potential explanatory variables, subjective memory complaints and impact of headache during ictal phase remained as individual determinants of the interictal burden, with SMC explaining 15% (odds ratio 1.15, 95% confidence interval 1.03–1.28; p = 0.010) of the interictal burden.ConclusionThis finding highlights the need to consider cognitive complaints as part of the construct of interictal burden of these patients to refine the focus of their management.
BRCA1‐associated‐protein‐1 inactivated melanocytic tumours: characterisation of the clinicopathological spectrum and immunohistochemical expression pattern of preferentially expressed antigen in melanoma
Authors: Xu Yitong , Gru Alejandro A , Brenn Thomas , Wiedemeyer Katharina 
Published: September 2024

AimsBRCA1‐associaed protein‐1 (BAP1) inactivated tumours (BIMT) are rare melanocytic tumours that may be mistaken for Spitz tumours or melanoma. They occur sporadically or in association with the BAP1 tumour predisposition syndrome (BAP1–TPDS), which may be complicated by uveal or cutaneous melanoma, mesothelioma, basal cell carcinoma and renal cell carcinoma. The aim of this study was to characterise the clinicopathological features and the immunohistochemical expression pattern of preferentially expressed antigen in melanoma (PRAME) of BIMT in a large patient cohort.Methods and resultsEthical approval was obtained, haematoxylin and eosin‐stained slides were reviewed, PRAME immunohistochemistry was performed and clinical follow‐up was obtained from patient records. Sixty‐five BIMT from 38 patients (F:M = 4.4:1) were identified. BIMT were typically located on the trunk and head and neck (median size = 0.5 cm). Seven patients with BAP1–TPDS (range = 16–66 years, median = 25) had multiple BIMT (median = 5), while sporadic BIMT were solitary (median patient age = 39 years). One of seven patients with BAP1–TPDS developed additional malignancies (mesothelioma and cutaneous spindle cell melanoma) and died of complications of mesothelioma. All other patients are alive without recurrence of BIMT (median follow‐up = 42 months). BIMT presented as intradermal, nodular aggregates of epithelioid melanocytes with low mitotic activity and moderate to severe cytological atypia in 63% of cases. A background conventional naevus was present in 64%. PRAME immunohistochemistry showed negative or weakly patchy positive staining in all BIMT.ConclusionsBIMT are more common in a sporadic setting and behave indolently, despite worrying cytological atypia. PRAME immunohistochemistry is a reassuring tool in distinguishing BIMT from melanoma.
Chemometric classification of Vietnamese green tea (Camellia sinensis) varieties and origins using elemental profiling and FTIR spectroscopy
Authors: Minh Truong Ngoc , Van Thinh Pham , Anh Hoang Le Tuan , Anh Le Viet , Khanh Nguyen Hoang , Van Nhan Le , Trung Nguyen Quang , Dat Nguyen Tien 
Published: September 2024

SummaryThe objective of this study was to employ multi‐elemental analysis and chemometric multivariate data analysis for identifying the geographical origin of Camellia sinensis cultivated in Vietnam's northeastern region. Ninety‐two tea leaf samples encompassing four distinct varieties were sourced from Bac Can and Thai Nguyen provinces. These samples underwent analysis through Fourier transform infrared (FTIR) spectroscopy and chemometrics, while elemental quantification was achieved via inductively coupled plasma mass spectrometry (ICP‐MS), utilising mixed standards for 26 elements. The FTIR spectra exhibited characteristic peaks, denoting the functional groups of the potential compounds present. ICP/MS analysis identified the presence of 14 elements in the tea samples, revealing significant variations in content across the four varieties. principal component analysis (PCA) of the FTIR data illustrated that the initial two principal components accounted for 91.26% of the total variance, effectively segregating the four green tea varieties into distinct clusters. Conversely, PCA of the ICP‐MS spectra also distinguished the four varieties, albeit Trung Du and Hybrid F1 exhibited a proximate distribution. This closeness may be incidental and not indicative of correlation, considering the limited variable set. Our findings ascertain that ICP/MS and FTIR, augmented by chemometric software, serve as efficacious tools for ascertaining the geographical origins of tea.
Frozen/Thawed Samples Can Replace Fresh Samples for Assignment of ISI to Secondary Thromboplastin Standards for Multiple Reagent/Instrument Combinations: Data to Support Possible Revision of WHO Guidelines
Authors: Kitchen Matthew , Bryant Michelle , Brown Paula , Woolley Anita , Kitchen Steve 
Published: September 2024

ABSTRACTBackgroundCalibration of thromboplastins is required for accurate calculation of the international normalised ratio (INR). Accurate INR results are required for optimal dosing of vitamin K antagonists. Decreases in vitamin K antagonist usage have made the recruitment of sample sets for international sensitivity index (ISI) calibrations more difficult. A possible solution to this would be to allow the use of frozen–thawed samples in place of fresh plasmas in the calibration of secondary standards.ObjectivesWe investigated the effect of freezing and thawing samples before usage in ISI calibrations of secondary standards.MethodsMultiple reagent/instruments were tested to identify the degree of difference between a fresh sample ISI calibration and one performed on frozen–thawed samples. Where possible, the two ISI calibrations were performed on the same sample set. Alternatively, a separate set of samples from different patients was used.ResultsThe difference in ISI values was <3% for those datasets where the same samples were used, and <6% for those datasets where two sample sets were used. Additionally, other parameters required for a valid ISI calibration showed only minor differences—some calibrations showed fewer outliers in the frozen–thawed datasets. Mean normal prothrombin time for the international reference thromboplastins was <3.5% different across four different calibrations (two for rabbit thromboplastin and two for recombinant human thromboplastin).ConclusionsThis modification to the WHO guidelines would facilitate the recruitment of test plasmas in advance of calibration solving the problem of requiring availability of fresh patient samples with a range of INRs in a 5‐h window.Trial Registration: Not a part of any clinical trial.
Evaluation of crack initiation load of silica glass surfaces formed during subcritical crack growth
Authors: Endo Jun , Sekine Tomomi , Shimizu Souta , Yoshida Satoshi 
Published: September 2024

AbstractThe crack initiation load of freshly fractured surfaces for silica glass was evaluated with ball indentation. The fracture surfaces were formed during subcritical crack growth in the regions I, II, and III of the stress intensity factor (KI)—crack velocity (V) curve. From the KI–V curve, we linked the obtained fracture surfaces with the ones in the regions I, II, and III. It was found that the crack‐forming probability was the lowest for the fracture surface formed in the region III of the KI–V curve. In order to understand the controlling factors of the crack formation, some properties which are topography, relative nonbridging oxygens (NBO), hydrogen concentrations, and Si–O three‐ or four‐membered ring structures, of the fracture surfaces were measured by atomic force microscopy, X‐ray photoelectron spectroscopy, dynamic secondary ion mass spectroscopy, and Raman spectroscopy, respectively. No distinct difference in NBO and hydrogen concentrations nor the ring structures were found among the fracture surfaces formed in different regions in the KI–V curve. The peak‐to‐valley height of the fracture surface, however, decreased with increasing crack velocity. It is concluded that the roughness or topography of the freshly fractured surface is one of the controlling factors which reduce the intrinsic strength of silica glass.
Thermal shock behavior of andalusite‐based refractories: Microstructural investigation of crack bridging and grain‐matrix interactions
Authors: Hahn Dominik , Shin Jong‐Won , Tissen David , Sax Almuth , Quirmbach Peter 
Published: September 2024

AbstractAndalusite‐based refractories are characterized by superior thermal shock resistance. Although the demand for alternative raw materials is increasing, it is proving difficult to replicate the thermal shock behavior of andalusite with alternative materials. The physico‐mechanical properties of andalusite refractories are well‐studied. However, comprehensive chemical and microstructural analysis is still needed to fully understand factors influencing the thermal shock resistance. This investigation highlights the use of complementary microstructural techniques (3D digital microscopy, scanning electron microscopy–energy‐dispersive X‐ray spectroscopy, and micro‐X‐ray fluorescence) to analyze crack propagation as well as glass bridge formation and composition in aluminosilicate‐based refractory castables. Andalusite‐based refractories are compared with chamotte 45 and chamotte 60, before and after a thermal shock, as well as after an additional firing. Factors influencing the thermal shock resistance of aluminosilicate refractory castables include (1) crack shape, size, occurrence, and propagation (2) glass bridge formation, size, occurrence, and composition, and (3) aggregate‐matrix interactions.
Magnetic and dielectric properties of low‐loss MnZn ferrites with wide temperature stability
Authors: Ying Yao , Chen Guo , Li Zhaocheng , Zheng Jingwu , Yu Jing , Qiao Liang , Li Wangchang , Li Juan , Wakiya Naoki , Yamaguchi Masahiro , Che Shenglei 
Published: September 2024

AbstractTo meet the needs for higher energy efficiency and a wide operating temperature range of electric vehicles, the low‐loss MnZn ferrites in a wide temperature range have been developed by optimizing the Fe content and the oxygen partial pressure (PO2) during the sintering process in this work. For the optimal sample, power loss at 300 kHz/100mT is 204 kW/m3 at 25°C and remains below 290 kW/m3 in the wide temperature range from ‐10 to 120°C. The loss separation method was employed to clarify the effects of the Fe content and PO2 on power loss. The equivalent circuit model has been employed to fit the complex impedance and it is found that the increase of PO2 enhances both the grain resistance Rg and the grain boundary resistance Rgb. The enhancement of Rgb is mainly responsible for the reduction of eddy current loss and consequently power loss. Dielectric permittivity is as large as about 15000 in this series of samples due to the electric polarization at the rich grain boundaries. Dielectric loss is very low between ‐50 and 150°C and has little contribution to the energy loss.
AI and Responsibility: No Gap, but Abundance
Authors: Kiener Maximilian 
Published: September 2024

ABSTRACTThe best‐performing AI systems, such as deep neural networks, tend to be the ones that are most difficult to control and understand. For this reason, scholars worry that the use of AI would lead to so‐called responsibility gaps, that is, situations in which no one is morally responsible for the harm caused by AI, because no one satisfies the so‐called control condition and epistemic condition of moral responsibility. In this article, I acknowledge that there is a significant challenge around responsibility and AI. Yet I don't think that this challenge is best captured in terms of a responsibility gap. Instead, I argue for the opposite view, namely that there is responsibility abundance, that is, a situation in which numerous agents are responsible for the harm caused by AI, and that the challenge comes from the difficulties of dealing with such abundance in practice. I conclude by arguing that reframing the challenge in this way offers distinct dialectic and theoretical advantages, promising to help overcome some obstacles in the current debate surrounding ‘responsibility gaps’.
Inhibition of sodium‐glucose cotransporter‐2 improves anaemia in mice and humans with sickle cell disease, and reduces infarct size in a murine stroke model
Authors: Wang Jintao , Silaghi Paul , Guo Chiao , Harro David , Eitzman Daniel T. 
Published: September 2024

AbstractSodium‐glucose cotransporter‐2 (SGLT‐2) is expressed in the kidney and may contribute to anaemia and cardiovascular diseases. The effect of SGLT‐2 inhibition on anaemia and vascular endpoints in sickle cell disease (SCD) is unknown. A murine model of SCD was studied to determine the effects of the SGLT‐2 inhibitor, empagliflozin, on anaemia and stroke size. The University of Michigan's Precision Health Database was used to evaluate the effect of SGLT‐2 inhibitors on anaemia in humans with SCD. SCD mice treated with daily empagliflozin for 8 weeks demonstrated increases in haemoglobin, haematocrit, erythrocyte counts, reticulocyte percentage and erythropoietin compared to vehicle‐treated mice. Following photochemical‐induced thrombosis of the middle cerebral artery, mice treated with empagliflozin demonstrated reduced stroke size compared to vehicle treated mice. In the electronic health records analysis, haemoglobin, haematocrit and erythrocyte counts increased in human SCD subjects treated with an SGLT‐2 inhibitor. SGLT‐2 inhibitor treatment of humans and mice with SCD is associated with improvement in anaemic parameters. Empagliflozin treatment is also associated with reduced stroke size in SCD mice suggesting SGLT‐2 inhibitor treatment may be beneficial with regard to both anaemia and vascular complications in SCD patients.
Lessons in cognition: A review of maze designs and procedures used to measure spatial learning in fish
Authors: Munson Amelia , DePasquale Cairsty 
Published: September 2024

AbstractThe use of different mazes to assess spatial learning has become more common in fish behavior studies in recent decades. This increase in fish cognition research has opened the door to numerous possibilities for exciting and diverse questions, such as identifying ecological drivers of spatial cognition and understanding the role individual variation plays in navigational abilities. There are many different types of mazes, each with its own specific considerations, making it challenging to determine exactly which spatial test is the most relevant and appropriate for a particular experiment. Many spatial mazes, such as the T‐maze and Y‐maze, have been successfully adapted from rodent studies, particularly with respect to zebrafish, a widely accepted non‐mammalian model in biomedical studies. Standardization across studies is increasing with these easily accessible maze designs, validating them for use in fish; however, variations in design (e.g., length of arms and scale) and procedure still exist, and the impact of these variations on results is largely unknown. The efforts to standardize mazes outside zebrafish work are also more limited. Other mazes have been developed specifically for use on fish, with design modifications varying widely, making it difficult to draw comparisons. In this review, we have highlighted the many design and procedural elements that should be considered for the acquisition of reliable behavioral data, with the goal of drawing readers' attention to aspects of experimentation that are often not given the careful consideration that they deserve. We then argue that additional focused research and reporting is needed to produce more reliable methods in spatial learning research across a broader range of subjects.
Evaluation of the potential probiotic Bacillus subtilis isolated from darkbarbel catfish (Pelteobagrus fulvidraco) on growth performance, serum immunity, and disease resistance of Aeromonas hydrophila
Authors: Hou Tinglong , Tang Zhengxian , Wang Zuobo , Li Chuntao 
Published: September 2024

AbstractThis study aimed to identify potential probiotic strains of Bacillus subtilis from healthy fish gut microbiota for application in aquaculture. The effects of dietary B. subtilis administration on growth performance, serum enzyme activity, immune gene expression, and disease resistance in darkbarbel catfish (Pelteobagrus fulvidraco) were investigated. The isolate, identified through gene sequencing and biochemical tests, demonstrated resilience to pH 3.0% and 6.0% bile, and exhibited extracellular protease, cellulose, lipase, and amylase production. Darkbarbel catfish were fed diets with varying B. subtilis concentrations (0 CFU/kg [T0], 107 CFU/kg [T1], 108 CFU/kg [T2], and 109 CFU/kg [T3]). After 8 weeks, significant increases (p < 0.05) were observed in final body weight, weight gain rate, specific growth rate, serum lysozyme, serum superoxide dismutase, alkaline phosphatase, and total antioxidant capacity, whereas malondialdehyde levels significantly decreased. Feeding darkbarbel catfish with B. subtilis diets increased immunoglobulin M (IgM) and C3 gene expression (p < 0.05), indicating a positive impact on the fish's immune system. The strain upregulated interleukin 10 (IL‐10) and transforming growth factor‐β (TGF‐β) expression and downregulated TNF‐α and IL‐1β, suggesting potential anti‐inflammatory effects. Following a 7‐day challenge with Aeromonas hydrophila, fish fed with B. subtilis exhibited lower mortality, with higher survival rates in the T2 and T3 groups. In conclusion, supplementing darkbarbel catfish diets with B. subtilis effectively enhances growth performance, immune response, and disease resistance.
Antimicrobial Efficacy of Peroxyacetic Acid Spray for Beef Carcasses and Cuts at Beef Processing Plants
Authors: Yang Xianqin , Wang Hui 
Published: September 2024

ABSTRACTThe objective of this study was to assess the antimicrobial efficacy of peroxyacetic acid (PAA) for beef in processing facilities. Inactivation of a wildtype Escherichia coli strain by up to 400 ppm PAA in solutions with different organic loads was determined. The microbial efficacy of PAA was assessed at two commercial beef plants for carcasses and cuts during routine production. The wild type E. coli strain was reduced by >7 log CFU upon exposing to PAA for 15 s at >100 and 200 ppm in low and high organic load solutions, respectively. PAA spray significantly reduced coliforms and E. coli by 1.7–2.0 log units on carcasses artificially inoculated with fecal slurry at one plant, and reduced aerobes and coliforms by 1.7 and 1.0 log units on naturally contaminated carcasses at the other plant. The reduction by PAA spray of aerobes (p < 0.05) on artificially inoculated carcasses was <0.5 log. Significant and consistent reduction of aerobes and coliforms on cuts by PAA was observed for fat surface at both beef plants, but not for lean cut surface. However, fewer cuts sprayed with PAA were positive for E. coli, regardless of cut type, compared with those that were not sprayed. Taken together, PAA can be effective for reducing microbial contamination of beef carcasses and cuts in commercial practice.
vNOTES scarless and painless endometrial cancer staging surgery
Authors: Şimşek Erkan , Yıldız Özge Akdeniz , Gündüz Sadık , Karakaş Sema , Yaşar Levent 
Published: September 2024

AbstractAimsSentinel lymph node dissection is performed in endometrial cancer surgery instead of staging surgery, particularly when the disease is advanced and confined to the uterus. The aim of this study is to share our sentinel lymph node detection rates via the vaginal natural orifice transluminal endoscopic surgery method with the literature and to demonstrate a safer and more comfortable surgical treatment process.MethodsThe analysis includes the patients who underwent surgery sentinel lymph node dissection for endometrial cancer utilizing indociyanin green in our center between January 2022 and June 2024.ResultsIn all, of 24 endometrial cancer patients underwent surgery sentinel lymph node dissection, nonendometrioid (serous) pathology was observed in only 1 (4%) patient, our other patients (96%) had endometrioid adenocarcinoma pathology. The rates of our sentinel lymph node dissection bilateral and symmetric are 96% (23/24), 94% (22/24), and 79% (19/24), respectively. We would like to emphasize that we successfully used vaginal natural orifice transluminal endoscopic surgery approach on four of our patients who were unsuitable for laparoscopic and robotic surgery due to pain scores of 2 at the 12th hour after surgery and low lung capacity.ConclusionsVaginal natural orifice transluminal endoscopic surgery and sentinel lymph node dissection will be considered as surgical options in other gynecological cancers due to the comfort it brings to the patient in endometrial cancer.
“I Am Because We Are”: The Role of Sub‐Saharan Africa's Collectivist Culture in Achieving Traceability and Global Supply Chain Resilience
Authors: Razak Ghadafi M. , Stevenson Mark , Hendry Linda C. 
Published: September 2024

ABSTRACTPrior studies on traceability as an enabler of supply chain resilience (SCRes) have focused on large‐scale disruptions and developed country contexts. Few studies have focused on developing countries where chronic, small‐scale disruptions are common and resource scarcity means advanced digital technologies are rarely adopted. This research explores how traceability is achieved across upstream actors in two Ghanaian agri‐food supply chains and how this affects global SCRes. Social characteristics are shown to influence the risks inherent in supply chains, while traceability is both a direct and indirect SCRes enabler. Informed by the relational view, the roles of relation‐specific assets and governance mechanisms in maintaining traceability are explored. Supply chain‐wide relation‐specific assets are prioritized over dyadic relation‐specific assets. This original finding is explained by the importance of maintaining social ties over short‐term economic gains in a collectivist culture, leading to greater relational rents in the long term. A novel, informal third‐party governance mechanism that reduces formal contracting costs and provides flexibility and continuity to interfirm relationships is also identified, further facilitating the attainment of relational rents. The findings are explained in light of sub‐Saharan Africa's collectivist culture, encapsulated in the philosophy of ubuntu. Overall, the research theorizes on achieving supply chain traceability and thus enhancing global SCRes as a sociotechnical system incorporating technological and nontechnological systems that are socially embedded in the local context.