bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bleeding complications and mortality in warfarin-treated VTE patients, dependence of INR variability and iTTR
Authors: Renlund Henrik , Svensson Peter J. , Själander Anders , Sandén Per 
Published: September 2016

SummaryHigh quality of warfarin treatment is important to prevent recurrence of venous thromboembolism (VTE) without bleeding complications. The aim of this study was to examine the effect of individual time in therapeutic range (iTTR) and International Normalised Ratio (INR) variability on bleeding risk and mortality in a large cohort of well-managed patients with warfarin due to VTE. A cohort of 16612 patients corresponding to 19502 treatment periods with warfarin due to VTE between January 1, 2006 and December 31, 2011 was retrieved from the Swedish national quality register AuriculA and matched with the Swedish National Patient Register for bleeding complications and background characteristics and the Cause of death register for occurrence and date of death. The rate of bleeding was 1.79 (confidence interval (CI) 95 % 1.66–1.93) per 100 treatment years among all patients. Those with poor warfarin treatment quality had a higher rate of clinically relevant bleeding, both when measured as iTTR below 70 %, 2.91 (CI 95 % 2.61–3.21) or as INR variability over the mean value 0.85, 2.61 (CI 95 % 2.36–2.86). Among those with both high INR variability and low iTTR the risk of clinically relevant bleeding was clearly increased hazard ratio (HR) 3.47 (CI 95 % 2.89–4.17). A similar result was found for all-cause mortality with a HR of 3.67 (CI 95 % 3.02–4.47). Both a low iTTR and a high INR variability increase the risk of bleeding complications or mortality. When combining the two treatment quality indicators patients at particular high risk of bleeding or death can be identified.
A randomised trial on platelet function-guided de-escalation of antiplatelet treatment in ACS patients undergoing PCI
Authors: Jacobshagen Claudius , Gross Lisa , Trenk Dietmar , Geisler Tobias , Orban Martin , Gori Tommaso , Hadamitzky Martin , Merkely Béla , Kiss Róbert , Komócsi András , Dézsi Csaba A. , Thalmeier Andreas , Löw Anja , Holdt Lesca , Teupser Daniel , Ince Hüseyin , Felix Stephan B. , Parma Radoslaw , Malek Lukasz , Horstkotte Jan , Baylacher Monika , Schwinger Robert , Rieber Johannes , Mudra Harald , Hausleiter Jörg , Huber Kurt , Neumann Franz-Josef , Koltowski Lukasz , Huczek Zenon , Mehilli Julinda , Massberg Steffen , Sibbing Dirk , Aradi Dániel ,   on behalf of the TROPICAL-ACS Investigators
Published: September 2016

SummaryOutcomes of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) have been significantly improved with the use of potent P2Y12 receptor inhibitors like prasugrel. While most of the ischaemic risk reduction for prasugrel versus clopidogrel was demonstrated in the early treatment period, the risk of bleeding became particularly prominent during the chronic course of therapy. It may therefore be a valid approach to substitute prasugrel for clopidogrel in the early phase of chronic antiplatelet treatment after PCI. In the Testing Responsiveness To Platelet Inhibition On Chronic Antiplatelet Treatment For Acute Coronary Syndromes (TROPICAL-ACS) trial, we aim to compare standard prasugrel therapy with a de-escalating antiplatelet treatment approach guided by platelet function testing (PFT). The study is an investigator-initiated European multicentre, randomised clinical trial in biomarker-positive ACS patients after successful PCI. Two thousand six hundred patients will be randomised prior to hospital discharge in a 1:1 fashion to either receive standard prasugrel therapy (control group) or de-escalating therapy (one-week prasugrel followed by one-week clopidogrel and PFT-guided maintenance therapy from day 14 after hospital discharge, monitoring group). Patients of the monitoring group with high on-clopidogrel platelet reactivity (HPR) based on Multiplate analyzer testing (HPR: ≥ 46U per consensus definition) will be switched back to prasugrel, whereas those without HPR (<46 U) will continue clopidogrel treatment. The overall study treatment duration will be one year in both groups. The primary endpoint of the study is net clinical benefit (combined incidence of cardiovascular death, myocardial infarction, stroke and bleeding ≥ grade 2 according to BARC criteria) one-year after randomisation. TROPICAL-ACS is the first large-scale, randomised controlled trial assessing the clinical value of a PFT-guided de-escalation of antiplatelet treatment in biomarker positive ACS patients undergoing PCI.ClinicalTrials.gov Identifier: NCT01959451
Distribution and losses of Tylenchulus semipenetrans in citrus orchards on reclaimed land in Egypt
Authors: Abd-Elgawad Mahfouz M.M. , Koura Faika F.H. , Montasser Sayed A. , Hammam Mostafa M.A. 
Published: September 2016

Four citrus orchards in Egypt were used in 2011 to study spread and losses of Tylenchulus semipenetrans based on a preliminary report of their infection in 2008. Soil and root samples indicated aggregated distribution and increase of nematode populations. The relationship between nematode number and lemon yield was described. When yield data of the mature groves were combined, we could construct other equations. The gain thresholds were 6.083 and 4.014 metric tons of lemon feddan−1 (= 4200 m−2) and the economic thresholds were 1810 and 141 second-stage juveniles (150 cm3 soil)−1 for cadusafos and oxamyl, respectively, based on the combined costs of nematode sampling and control to provide an actual estimate of a budget conscious choice. The use of healthy material is compulsory for tackling this problem in Egypt as a case in point. It entails setting up a citrus certification programme. Other phytosanitary measures to protect citriculture interests in Egypt are discussed.
Bottom Boundary Potential Vorticity Injection from an Oscillating Flow: A PV Pump
Authors: Ruan Xiaozhou , Thompson Andrew F. 
Published: September 2016

AbstractOceanic boundary currents over the continental slope exhibit variability with a range of time scales. Numerical studies of steady, along-slope currents over a sloping bathymetry have shown that cross-slope Ekman transport can advect buoyancy surfaces in a bottom boundary layer (BBL) so as to produce vertically sheared geostrophic flows that bring the total flow to rest: a process known as buoyancy shutdown of Ekman transport or Ekman arrest. This study considers the generation and evolution of near-bottom flows due to a barotropic, oscillating, and laterally sheared flow over a slope. The sensitivity of the boundary circulation to changes in oscillation frequency ω, background flow amplitude, bottom slope, and background stratification is explored. When ω/f ≪ 1, where f is the Coriolis frequency, oscillations allow the system to escape from the steady buoyancy shutdown scenario. The BBL is responsible for generating a secondary overturning circulation that produces vertical velocities that, combined with the potential vorticity (PV) anomalies of the imposed barotropic flow, give rise to a time-mean, rectified, vertical eddy PV flux into the ocean interior: a “PV pump.” In these idealized simulations, the PV anomalies in the BBL make a secondary contribution to the time-averaged PV flux. Numerical results show the domain-averaged eddy PV flux increases nonlinearly with ω with a peak near the inertial frequency, followed by a sharp decay for ω/f > 1. Different physical mechanisms are discussed that could give rise to the temporal variability of boundary currents.
A survey exploring self‐reported indoor and outdoor footwear habits, foot problems and fall status in people with stroke and Parkinson's
Authors: Bowen Catherine , Ashburn Ann , Cole Mark , Donovan‐Hall Margaret , Burnett Malcolm , Robison Judy , Mamode Louis , Pickering Ruth , Bader Dan , Kunkel Dorit 
Published: September 2016

AbstractBackgroundIll‐fitting shoes have been implicated as a risk factor for falls but research to date has focused on people with arthritis, diabetes and the general older population; little is known about people with neurological conditions. This survey for people with stroke and Parkinson's explored people's choice of indoor and outdoor footwear, foot problems and fall history.MethodsFollowing ethical approval, 1000 anonymous postal questionnaires were distributed to health professionals, leads of Parkinson's UK groups and stroke clubs in the wider Southampton area, UK. These collaborators handed out survey packs to people with a confirmed diagnosis of stroke or Parkinson's.ResultsThree hundred and sixty three completed surveys were returned (218 from people with Parkinson's and 145 from people with stroke). Most respondents wore slippers indoors and walking shoes outdoors and considered comfort and fit the most important factors when buying footwear. Foot problems were reported by 43 % (95 % confidence intervals 36 to 52 %; stroke) and 53 % (95 % confidence interval 46 to 59 %; Parkinson's) of respondents; over 50 % had never accessed foot care support. Fifty percent of all respondents reported falls. In comparison to non‐fallers, a greater proportion of fallers reported foot problems (57 %), with greater proportions reporting problems impacting on balance and influencing choice of footwear (p < 0.01) in comparison to non‐fallers in each case. Forty‐seven percent of fallers with foot problems had not accessed foot care support.ConclusionsMany people with stroke and Parkinson's wear slippers indoors. A high percentage of these individuals reported both foot problems and falls impacting on footwear habits and choice of footwear; however many did not receive foot care support. These findings highlight that further exploration of footwear and foot problems in these populations is warranted to provide evidence based advice on safe and appropriate footwear to support rehabilitation and fall prevention.
Skill composition of immigration flows and the measurement of education-occupation mismatch
Authors: Poot Jacques , Stillman Steven 
Published: September 2016

Abstract
Recent papers have found that often immigrants are overqualified relative to native-born workers when comparing an individual’s education to the ‘average’ education in their occupation. We show that these results are sensitive to differences in the education distribution between immigrants and the native born. Using data for New Zealand, which has an immigration policy that favours skilled immigrants, we find that this approach leads one to conclude that immigrants are, on average, overqualified for their occupation. However, once we account for the fact that immigrants are on average more skilled than natives, we find that immigrants are, in fact, less overeducated than natives.

JEL classification: F22, J21, J61
A review of M. A. K. Halliday, Aspects of Language and Learning
Authors: Yu Hui 
Published: September 2016

AbstractThis volume was published as one of the “M.A.K. Halliday Library Functional Linguistics” Series. It is based on a series of lectures given by Professor Halliday at the National University of Singapore in 1986. The theme of these lectures is to construct a linguistically informed theory of education, providing a linguistic interpretation of how people learn. The lectures as a whole provide an essential framework of Halliday’s ideas on language, knowledge and education.
PRL-3 disrupts epithelial architecture by altering the post-mitotic midbody position
Authors: Luján Pablo , Varsano Giulia , Rubio Teresa , Hennrich Marco L. , Sachsenheimer Timo , Gálvez-Santisteban Manuel , Martín-Belmonte Fernando , Gavin Anne-Claude , Brügger Britta , Köhn Maja 
Published: September 2016

ABSTRACT
Disruption of epithelial architecture is a fundamental event during epithelial tumorigenesis. We show that the expression of the cancer-promoting phosphatase PRL-3 (PTP4A3), which is overexpressed in several epithelial cancers, in polarized epithelial MDCK and Caco2 cells leads to invasion and the formation of multiple ectopic, fully polarized lumens in cysts. Both processes disrupt epithelial architecture and are hallmarks of cancer. The pathological relevance of these findings is supported by the knockdown of endogenous PRL-3 in MCF-7 breast cancer cells grown in three-dimensional branched structures, showing the rescue from multiple-lumen- to single-lumen-containing branch ends. Mechanistically, it has been previously shown that ectopic lumens can arise from midbodies that have been mislocalized through the loss of mitotic spindle orientation or through the loss of asymmetric abscission. Here, we show that PRL-3 triggers ectopic lumen formation through midbody mispositioning without altering the spindle orientation or asymmetric abscission, instead, PRL-3 accelerates cytokinesis, suggesting that this process is an alternative new mechanism for ectopic lumen formation in MDCK cysts. The disruption of epithelial architecture by PRL-3 revealed here is a newly recognized mechanism for PRL-3-promoted cancer progression.
Adolescent depression aetiology: A systematic review
Authors: Littler Nadine 
Published: September 2016

Background: Depression in adolescents is a key public health issue for children and young people, therefore in order to tackle this, we must first explore the aetiology of depression by examining the biological, environmental, sociological and psychological risk pathways. Methods: A review of the literature was undertaken between the years 2010-2015 to identify key themes and areas of development. Results: The exposure to a range of environmental and sociological factors, in addition to pre-existing biological and cognitive vulnerabilities may considerably increase the risk of adolescents developing depression. Furthermore evidence suggests distinctive male and female brain developmental trajectories during adolescence, thus highlighting the need for further research within this field, in order to educate young people, parents/carers and professionals and to promote the early identification of depression.
Digitally mediated keyboard learning: Speed of mastery, level of retention and student perspectives
Authors: Cremata Radio , Powell Bryan 
Published: September 2016

Abstract
In this study, four different media were investigated regarding learning to play keyboard instruments on beginning level musical selections. Among these were Synthesia, eMedia, YouTube piano tutorials and standard Paper Notation. A sample of 564 beginning keyboard instrument students in grades 6–12 was measured on timed learning tasks to determine speed to mastery, level of retention and perspectives. Results indicated that Synthesia was more effective than the other three learning approaches at enabling students to quickly master beginning level songs and retain that information on a post-test seven days later. These data are potentially transformative in providing open access, efficient, relevant, personalized and effective music education experiences to greater numbers of students who might be marginalized.
Revitalizing music teacher preparation with selected ‘Essential Conditions’
Authors: Gilbert Danni 
Published: September 2016

Abstract
The widespread adoption of technology makes it necessary to extend technological resources to the classroom to best prepare students for long-term success. While technology can improve many facets of learning and teaching, music educators have generally been hesitant to incorporate technology to its full potential. Partnerships with professional organizations, such as the International Society for Technology in Education (ISTE), can help music educators best reach students and achieve cultural relevancy in the digital age. Restructuring music education to integrate what ISTE calls ‘Essential Conditions’ of learning with technology, such as student-centred learning, equitable access and engaged communities, begins with undergraduate music education preparation. The purpose of this article is to identify the necessity of a synergism between music education and selected ISTE ‘Essential Conditions’ for technology-based learning, describe implications these selected conditions have on the current state of American undergraduate music education programmes, and provide recommendations for music teacher education.
Introducing technology in Cypriot primary classroom music lessons: ‘I learnt using things in music I didn’t know existed’
Authors: Konstantinou Chrysovalentini 
Published: September 2016

Abstract
This articles presents issues around the introduction and use of technology in primary music education with particular reference to a study set in Cyprus that looks at the change in teachers’ practices, thinking and concerns as they become more engaged with technology and use it more. It examines the availability and use of technology in music lessons, the development of creative thinking and teaching with technology and the elements that facilitate the introduction and use of technology in music lessons. The study examines the cases of ten primary music teachers in Cyprus and uses interviews, questionnaires, observations and teacher reflection. It was indicated that if encouraged and provided with the technology, education, support and training they need, teachers can overcome their hesitations and use technology in their lessons.
feature article: Are our malls safe? Race and neoliberal discourse in Ruben Östlund’s Play
Authors: Gullette Christian 
Published: September 2016

Abstract
This article argues that Swedish director Ruben Östlund’s much-debated film Play (2011) codes racial differentiation in discourses of neoliberal economic competitiveness, able-bodiedness and masculinity in order to negotiate anxiety over white economic privilege and futurity in the contemporary Swedish marketplace and society.
feature article: The Danish producer in an era of convergence and globalization: An interview with Meta Louise Foldager
Authors: Meir Christopher 
Published: September 2016

Abstract
Producers are seldom the focus of screen studies research, but this interview with Danish producer Meta Louise Foldager demonstrates just how useful these vital creators are to understanding the Scandinavian film and television industries, both of which currently find themselves in periods of rapid change. The interview focuses on three themes: the differing roles that the producer plays in film and television production; the state of the Danish film industry; and the burgeoning television drama industry in Denmark. Throughout these three sections, Foldager discusses how local and global forces are influencing her work and that of her colleagues in both industries.
Convex Hull Property and Exclosure Theorems
for H-Minimal Hypersurfaces in Carnot Groups
Authors: Montefalcone Francescopaolo 
Published: September 2016

Abstract
In this paper, we generalize to sub-Riemannian Carnot groups some classical results in the theory
of minimal submanifolds. Our main results are for step 2 Carnot groups. In this case, we will prove the
convex hull property and some “exclosure theorems” for H-minimal hypersurfaces of class C2 satisfying a
Hörmander-type condition.
Evaluation of the hypochromic erythrocyte and reticulocyte hemoglobin content provided by the Sysmex XE-5000 analyzer in diagnosis of iron deficiency erythropoiesis
Authors: Buttarello Mauro , Pajola Rachele , Novello Enrica , Mezzapelle Giacomo , Plebani Mario 
Published: September 2016

Abstract

Background:
Iron deficiency represents the most frequent cause of anemia. To diagnose iron deficiency some biochemical tests such as serum ferritin and the transferring saturation percent (TSAT%) are usually used. Recently, some hematological parameters such as mean reticulocyte hemoglobin content (CHr or Ret-He) and percentage of hypochromic RBCs (Hypo% or %Hypo-He) were proposed as alternative to biochemical tests. In this study, the analytic performance and the diagnostic efficiency of these two parameters provided by Sysmex XE5000 analyzer on iron deficiency patients with or without anemia (IDA and ID, respectively) were evaluated.

Methods:
One hundred and sixty-four healthy adults, 58 with IDA, 21 with iron depleted stores (ID), 23 with β-thalassemia trait, and 24 with non iron deficiency anemia were selected. The gold standard used to define iron deficiency was the coexistence of serum ferritin below 15 μg/L (12 in women) and TSAT <16%.

Results:
For %Hypo-He, the best cut-off value for both IDA and ID is 0.9% while for Ret-He is 30.6 pg. For both parameters the performance was better to diagnose IDA (AUC, 0.96 and 0.98) than ID (AUC, 0.93 and 0.95). The Ret-He behavior was always slightly better than that of %Hypo-He.

Conclusions:
The use of these two parameters is useful to detect iron deficiency conditions if the hemoglobin synthesis has already been compromised.
Spanish Preanalytical Quality Monitoring Program (SEQC), an overview of 12 years’ experience
Authors: Llopis María Antonia , Bauça Josep Miquel , Barba Nuria , Álvarez Virtudes , Ventura Montserrat , Ibarz Mercè , Gómez-Rioja Rubén , Marzana Itziar , Puente Juan Jose , Segovia Marta , Martinez Debora , Alsina María Jesús 
Published: September 2016

AbstractBackground:Preanalytical variables, such as sample collection, handling and transport, may affect patient results. Preanalytical phase quality monitoring should be established in order to minimize laboratory errors and improve patient safety.Methods:A retrospective study (2001–2013) of the results obtained through the Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC) External quality assessment (preanalytical phase) was performed to summarize data regarding the main factors affecting preanalytical phase quality. Our aim was to compare data from 2006 to 2013 with a previously published manuscript assessing the 2001–2005 period.Results:A significant decrease in rejection rates was observed both for blood and urine samples. For serum samples, the most frequent rejection causes in the first period were non-received samples (37.5%), hemolysis (29.3%) and clotted samples (14.4%). Conversely, in the second period, hemolysis was the main rejection cause (36.2%), followed by non-received samples (34.5%) and clotted samples (11.1%). For urine samples, the main rejection cause overall was a non-received sample (up to 86.1% of cases in the second period, and 81.6% in the first). For blood samples with anticoagulant, the number of rejections also decreased. While plasma-citrate-ESR still showed the highest percentages of rejections (0.980% vs. 1.473%, p<0.001), the lowest corresponded to whole-blood EDTA (0.296% vs. 0.381%, p<0.001).Conclusions:For the majority of sample types, a decrease in preanalytical errors was confirmed. Improvements in organization, implementation of standardized procedures in the preanalytical phase, and participation in a Spanish external quality assessment scheme may have notably contributed to error reduction in this phase.
An extention of Nomizu’s Theorem
–A user’s guide–
Authors: Kasuya Hisashi 
Published: September 2016

Abstract
For a simply connected solvable Lie group G with a lattice Γ, the author constructed an explicit
finite-dimensional differential graded algebra A*Γ which computes the complex valued de Rham cohomology
H*(Γ\G, C) of the solvmanifold Γ\G. In this note, we give a quick introduction to the construction of such A*Γ including a simple proof of H*(A*Γ) ≅ H*(Γ\G, C).