bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myeloid-derived suppressor cells contribute to systemic lupus erythaematosus by regulating differentiation of Th17 cells and Tregs
Authors: Ji Jianjian , Xu Jingjing , Zhao Shuli , Liu Fei , Qi Jingjing , Song Yuxian , Ren Jing , Wang Tingting , Dou Huan , Hou Yayi 
Published: May 2016

Although major advancements have made in investigating the aetiology of SLE (systemic lupus erythaematosus), the role of MDSCs (myeloid-derived suppressor cells) in SLE progression remains confused. Recently, some studies have revealed that MDSCs play an important role in lupus mice. However, the proportion and function of MDSCs in lupus mice and SLE patients are still poorly understood. In the present study, we investigated the proportion and function of MDSCs using different stages of MRL/lpr lupus mice and specimens from SLE patients with different activity. Results showed that splenic granulocytic (G-)MDSCs were significantly expanded by increasing the expression of CCR1 (CC chemokine receptor 1) in diseased MRL/lpr lupus mice and in high-disease-activity SLE patients. However, the proportion of monocytic (M-)MDSCs remains similar in MRL/lpr lupus mice and SLE patients. G-MDSCs produce high levels of ROS (reactive oxygen species) through increasing gp91phox expression, and activated TLR2 (Toll-like receptor 2) and AIM2 (absent in melanoma 2) inflammasome in M-MDSCs lead to IL-1β (interleukin 1β) expression in diseased MRL/lpr mice and high-disease-activity SLE patients. Previous study has revealed that MDSCs could alter the plasticity of Th17 (T helper 17) cells and Tregs (regulatory T-cells) via ROS and IL-1β. Co-culture experiments showed that G-MDSCs impaired Treg differentiation via ROS and M-MDSCs promoted Th17 cell polarization by IL-1β in vitro. Furthermore, adoptive transfer or antibody depletion of MDSCs in MRL/lpr mice confirmed that MDSCs influenced the imbalance of Tregs and Th17 cells in vivo. Our results indicate that MDSCs with the capacity to regulate Th17 cell/Treg balance may be a critical pathogenic factor in SLE.
Catch and Exploitation of Shoal Bass in the Flint River, Georgia, USA: Implications for Harvest Restrictions
Authors: Sammons Steven M. 
Published: May 2016

Abstract
Shoal Bass Micropterus cataractae are endemic to the Apalachicola River basin (Alabama, Florida, and Georgia) and support popular fisheries, yet little is known about the population dynamics or angler harvest of this species. To estimate the annual exploitation rate (u), 376 Shoal Bass were tagged at 16 sites over a 208-km stretch of the Flint River, Georgia, during 2008–2011. Mean annual u varied from 0.22 to 0.26, but because of the high movement rates of tagged fish, it was not possible to calculate true u for specific sites along the Flint River. The catch rate of tagged, sedentary Shoal Bass was relatively similar between areas that were accessible by motorboat (0.38) and those accessible only by canoe or kayak (0.32); however, u was 2.5 times higher in the motorboat-accessible areas (0.22) than in motorboat-inaccessible areas (0.09). The effects of three length limits (the current minimum length limit [MLL] of 305 mm TL; an MLL of 381 mm TL; and a protected slot limit of 356–432 mm TL) on the Shoal Bass population were explored by using an age-structured model. Results indicated that growth overfishing did not occur with the current (305-mm) MLL under the observed range of u, but few fish (≤3%) reached 457 mm, indicating that the population's size structure was likely limited by harvest. The 381-mm MLL was predicted to cause little decline in yield while (1) decreasing the number of harvested Shoal Bass by 41–42% and (2) increasing the number reaching 457 mm by 37–66%. Performance of the slot limit was similar to that of the 381-mm MLL in terms of yield and the number of fish reaching 457 mm, but the slot limit was predicted to increase the number of harvested fish by 15–17% relative to the 305-mm MLL and by almost two-fold relative to the 381-mm MLL. The Flint River Shoal Bass fishery is unlikely to achieve a trophy component under the 305-mm MLL at the observed levels of u. Based on the results of this study, the Georgia Department of Natural Resources adopted a 381-mm MLL for this reach of the Flint River on September 17, 2014.
Received May 27, 2015; accepted January 19, 2016 Published online May 26, 2016
Two-Stage Boosted Regression Tree Model to Characterize Southern Flounder Distribution in Texas Estuaries at Varying Population Sizes
Authors: Froeschke John T. , Froeschke Bridgette F. 
Published: May 2016

Abstract
Linking trends in fish population abundance to environmental characteristics is often difficult because fish use a variety of habitats throughout their ontogeny and may exhibit large interannual fluctuations in abundance. We developed a two-stage boosted regression tree model to investigate spatiotemporal patterns of Southern Flounder Paralichthys lethostigma abundance and distribution in Texas estuaries. We used a 36-year fishery-independent data set (1977–2012) to correlate distribution with environmental conditions and seasonal or long-term changes in abundance. Adult Southern Flounder were sampled with gill nets using a random-stratified design. Predictions of abundance were made to grids of environmental data to identify “hot spots” as well as seasonal or decadal shifts in distribution. Models were fit using cross validation, and variance was estimated using nonparametric bootstrapping. Depth, temperature, distance to a tidal inlet, and salinity were the primary environmental determinants of Southern Flounder distribution and abundance. Because distribution and response to environmental conditions can depend on population abundance, we also developed a standardized index of annual abundance using the same two-stage boosted regression tree model. The index identifies a long-term decline in abundance punctuated by recent recovery (possibly in response to management actions). Mapped results identify a coastwide decline in abundance between 1980–1984 and 2005–2009 but the magnitude varied substantially, suggesting disproportionate changes in abundance across the study area.
Received April 10, 2015; accepted July 28, 2015
Cosmological N-body simulations with suppressed variance
Authors: Angulo Raul E. , Pontzen Andrew 
Published: May 2016

Abstract
We present and test a method that dramatically reduces variance arising from the sparse sampling of wavemodes in cosmological simulations. The method uses two simulations which are fixed (the initial Fourier mode amplitudes are fixed to the ensemble average power spectrum) and paired (with initial modes exactly out of phase). We measure the power spectrum, monopole and quadrupole redshift-space correlation functions, halo mass function and reduced bispectrum at z = 1. By these measures, predictions from a fixed pair can be as precise on non-linear scales as an average over 50 traditional simulations. The fixing procedure introduces a non-Gaussian correction to the initial conditions; we give an analytic argument showing why the simulations are still able to predict the mean properties of the Gaussian ensemble. We anticipate that the method will drive down the computational time requirements for accurate large-scale explorations of galaxy bias and clustering statistics, and facilitating the use of numerical simulations in cosmological data interpretation.
The Influence of Patient and Provider Communication on Diabetes Care Delivery
Authors: Young Staci A. , Azam Laila S. , Meurer John R. , Hill Renee S. , Cui Chen 
Published: May 2016

Purpose:
To elicit the perspective of patients with type 2 diabetes, specific to communication with providers and health care teams.

Methods:
We conducted 21 focus groups with 115 adults in Midwestern primary care, endocrinology, and bariatric surgery clinics. Facilitators analyzed the transcripts using an iterative coding method.

Results:
The themes of encouragement and motivation, relationship building, compassion, and communication preferences highlighted effective strategies consistent with the core components of patient-centered care.

Conclusions:
Patients and providers benefit from systems in which patients are efficiently and compassionately supported in self-management within their abilities and in partnership with their support networks.
The Influence of Different OK Lens Designs on Peripheral Refraction
Authors: Kang Pauline , Swarbrick Helen 
Published: May 2016

ABSTRACT

Purpose
To compare peripheral refraction changes along the horizontal and vertical meridians induced by three different orthokeratology (OK) lens designs: BE, Paragon CRT, and Contex lenses.

Methods
Nineteen subjects (6M, 13F, mean age 28 ± 7 years) were initially fitted with BE OK lenses in both eyes which were worn overnight for 14 days. Central and peripheral refraction and corneal topography were measured at baseline and after 14 nights of lens wear. After a minimum 2-week washout period, one randomly selected eye was re-fitted with a Paragon CRT lens and the other eye with a Contex OK lens. Measurements were repeated before and after 14 nights of lens wear.

Results
The three different OK lenses caused significant changes in peripheral refraction along both the horizontal and vertical visual fields (VFs). BE and Paragon CRT lenses induced a significant hyperopic shift within the central ±20° along the horizontal VF and at all positions along the vertical meridian except at 30° in the superior VF. There were no significant differences in peripheral refraction changes induced between BE and Paragon CRT lenses. When comparing BE and Contex OK lens designs, BE caused greater hyperopic shifts at 10° and 30° in the temporal VF and at center, 10°, and 20° in the superior VF along the vertical meridian. Furthermore, BE lenses caused greater reduction in Flat and Steep K values compared to Contex OK.

Conclusions
OK lenses induced significant changes in peripheral refraction along the horizontal and vertical meridians. Despite the clinically significant difference in central corneal flattening induced by BE and Contex OK lenses, relative peripheral refraction changes differed minimally between the three OK lens designs. If the peripheral retina influences refractive error development, these results suggest that myopia control effects are likely to be similar between different OK lens designs.
Heavy Alcohol Use Is Associated With Worse Retention in HIV Care
Authors: Monroe Anne K. , Lau Bryan , Mugavero Michael J. , Mathews William C. , Mayer Kenneth H. , Napravnik Sonia , Hutton Heidi E. , Kim Hongseok S. , Jabour Sarah , Moore Richard D. , McCaul Mary E. , Christopoulos Katerina A. , Crane Heidi C. , Chander Geetanjali 
Published: May 2016

Background:
Poor retention in HIV care is associated with worse clinical outcomes and increased HIV transmission. We examined the relationship between self-reported alcohol use, a potentially modifiable behavior, and retention.

Methods:
A total of 9694 people living with HIV from 7 participating US HIV clinical sites (the Centers for AIDS Research Network of Integrated Clinical Systems) contributed 23,225 observations from January 2011 to June 2014. The retention outcomes were (1) Institute of Medicine (IOM) retention: 2 visits within 1 year at least 90 days apart and (2) visit adherence [proportion of kept visits/(scheduled + kept visits)]. Alcohol use was measured with Alcohol Use Disorders Identification Test-C, generating drinking (never, moderate, and heavy) and binge frequency (never, monthly/less than monthly, weekly/daily) categories. Adjusted multivariable logistic models, accounting for repeat measures, were generated.

Results:
Of our sample, 82% was men, 46% white, 35% black, and 14% Hispanic. At first assessment, 37% of participants reported never drinking, 38% moderate, and 25% heavy, and 89% of the patients were retained (IOM retention measure). Participants' mean (SD) visit adherence was 84% (25%). Heavy alcohol use was associated with inferior IOM-defined retention (adjusted odds ratio 0.78, 95% confidence interval: 0.69 to 0.88), and daily/weekly binge drinking was associated with lower visit adherence (adjusted odds ratio = 0.90, 95% confidence interval: 0.82 to 0.98).

Conclusions:
Both heavy drinking and frequent binge drinking were associated with worse retention in HIV care. Increased identification and treatment of heavy and binge drinking in HIV clinical care settings may improve retention in HIV care, with downstream effects of improved clinical outcomes and decreased HIV transmission.
Operations and maintenance issues in the offshore wind energy sector
Authors: Baagøe-Engels Victoria , Stentoft Jan 
Published: May 2016

Purpose
There is increasing research interest in the expansion of the offshore wind energy sector. Recent research shows that operations and maintenance (O&M) account for around 20-35 per cent of the total energy costs in this sector. The purpose of this paper is to provide an overview of O&M issues in the offshore wind energy sector to propose initiatives that can help reduce the cost of energy used by offshore wind farms.

Design/methodology/approach
The paper is based on an in-depth literature review and a Delphi study of a panel of 16 experts on O&M.

Findings
Consisting primarily of conceptual papers and/or modelling papers, the extant literature identifies several challenges for O&M in the offshore wind energy sector. These challenges can be grouped into four categories: issues related with industry immatureness; distance/water depth; weather window; and policy issues. The Delphi study identified three other major issues that lead to increased O&M costs: too many predefined rules that limit development; lack of coordinated planning of the different services offered at the wind farms; and lack of a common approach on how O&M should be managed strategically.

Research limitations/implications
The present study is based only on Danish respondents. Future research needs to include various respondents from different countries to identify country-specific contingencies.

Practical implications
The paper provides an overview of the O&M issues in the offshore wind energy sector to prioritize where future resources should be invested and, thus, reduce O&M costs.

Originality/value
This is the first paper on O&M issues that bridges both literature studies and industry expert opinions.
Corporate social entrepreneurship in India
Authors: Agrawal Anirudh , Sahasranamam Sreevas 
Published: May 2016

Purpose– The purpose of this paper is to analyze how corporations create social and economic value through corporate social entrepreneurial activities.Design/methodology/approach– This paper employs a multiple case study approach. The selected cases cover companies that have a clear corporate social enterprise model in operation and address different prevailing social problems.Findings– This study reveals that corporate social entrepreneurship (CSE) is driven by the environmental dynamics, organizational antecedents, and organizational outcomes. In addition, the authors found that CSE provides companies with both implicit and explicit strategic benefits. Based on the findings the authors propose an integrated model of CSE.Research limitations/implications– As all cases originate from India the authors cannot rule out the possibility that the conclusions are only valid for a certain institutional and socio-economical context.Practical implications– The developed model is useful for companies operating in complex environments in developing markets as it provides recommendations on how to strengthen social and public legitimacy and earn returns on their business investments. Moreover, the developed model helps companies operating in antagonistic environments with prevailing social problems to position themselves favorably.Social implications– The study attempts to legitimize the practice of CSE by highlighting the positive financial, social, and political outcomes.Originality/value– This study presents an integrated model of CSE in the Indian context and outlines how corporations can draw implicit and explicit benefits.
Comparative genomic, proteomic and exoproteomic analyses of three Pseudomonas strains reveals novel insights into the phosphorus scavenging capabilities of soil bacteria
Authors: Lidbury Ian D. E. A. , Murphy Andrew R. J. , Scanlan David J. , Bending Gary D. , Jones Alexandra M. E. , Moore Jonathan D. , Goodall Andrew , Hammond John P. , Wellington Elizabeth M. H. 
Published: May 2016

SummaryBacteria that inhabit the rhizosphere of agricultural crops can have a beneficial effect on crop growth. One such mechanism is the microbial‐driven solubilization and remineralization of complex forms of phosphorus (P). It is known that bacteria secrete various phosphatases in response to low P conditions. However, our understanding of their global proteomic response to P stress is limited. Here, exoproteomic analysis of Pseudomonas putida BIRD‐1 (BIRD‐1), Pseudomonas fluorescens SBW25 and Pseudomonas stutzeri DSM4166 was performed in unison with whole‐cell proteomic analysis of BIRD‐1 grown under phosphate (Pi) replete and Pi deplete conditions. Comparative exoproteomics revealed marked heterogeneity in the exoproteomes of each Pseudomonas strain in response to Pi depletion. In addition to well‐characterized members of the PHO regulon such as alkaline phosphatases, several proteins, previously not associated with the response to Pi depletion, were also identified. These included putative nucleases, phosphotriesterases, putative phosphonate transporters and outer membrane proteins. Moreover, in BIRD‐1, mutagenesis of the master regulator, phoBR, led us to confirm the addition of several novel PHO‐dependent proteins. Our data expands knowledge of the Pseudomonas PHO regulon, including species that are frequently used as bioinoculants, opening up the potential for more efficient and complete use of soil complexed P.
Biogenic Amines in Dairy Products: Origin, Incidence, and Control Means
Authors: Benkerroum Noreddine 
Published: May 2016

AbstractBiogenic amines (BAs) are toxic compounds produced by a number of microorganisms (bacteria, yeasts, and molds) as a result of the metabolism of some amino acid, usually decarboxylation reactions. BA‐producing microorganisms are not necessarily pathogenic, such as lactic acid bacteria, which are, on the contrary, among the most beneficial microbiota to human beings and some of which even have probiotic properties. However, the incidence of BAs in dairy products and their possible implication in serious dairy‐borne intoxications has long been overlooked. Consequently, the implementation of control measures to limit such an incidence has not been considered among the priorities of the food safety authorities. Nonetheless, there is a growing concern with regard to the presence of BAs in dairy products, because their toxicological status as toxins that may have serious acute and/or chronic adverse health effects is becoming increasingly evident and well‐documented. The main BAs associated with dairy products are reviewed herein from the perspective of their incidence in these food products, and to draw the attention of readers to the shortage in data to perform pertinent risk assessment, which is considered to be a key action to provide efficient control means and to help decision makers issue appropriate legislative and regulatory measures.
Spectroscopic determination of ecologically relevant plant secondary metabolites
Authors: Couture John J. , Singh Aditya , Rubert‐Nason Kennedy F. , Serbin Shawn P. , Lindroth Richard L. , Townsend Philip A. 
Published: May 2016

Summary

Spectroscopy has recently emerged as an effective method to accurately characterize leaf biochemistry in living tissue through the application of chemometric approaches to foliar optical data, but this approach has not been widely used for plant secondary metabolites. Here, we examine the ability of reflectance spectroscopy to quantify specific phenolic compounds in trembling aspen (Populus tremuloides) and paper birch (Betula papyrifera) that play influential roles in ecosystem functioning related to trophic‐level interactions and nutrient cycling.

Spectral measurements on live aspen and birch leaves were collected, after which concentrations of condensed tannins (aspen and birch) and salicinoids (aspen only) were determined using standard analytical approaches in the laboratory. Predictive models were then constructed using jackknifed, partial least squares regression (PLSR). Model performance was evaluated using coefficient of determination (R2), root‐mean‐square error (RMSE) and the per cent RMSE of the data range (%RMSE).

Condensed tannins of aspen and birch were well predicted from both combined (R2 = 0·86, RMSE = 2·4, %RMSE = 7%)‐ and individual‐species models (aspen: R2 = 0·86, RMSE = 2·4, %RMSE = 6%; birch: R2 = 0·81, RMSE = 1·9, %RMSE = 10%). Aspen total salicinoids were better predicted than individual salicinoids (total: R2 = 0·76, RMSE = 2·4, %RMSE = 8%; salicortin: R2 = 0·57, RMSE = 1·9, %RMSE = 11%; tremulacin: R2 = 0·72, RMSE = 1·1, %RMSE = 11%), and spectra collected from dry leaves produced better models for both aspen tannins (R2 = 0·92, RMSE = 1·7, %RMSE = 5%) and salicinoids (R2 = 0·84, RMSE = 1·4, %RMSE = 5%) compared with spectra from fresh leaves. The decline in prediction performance from total to individual salicinoids and from dry to fresh measurements was marginal, however, given the increase in detailed salicinoid information acquired and the time saved by avoiding drying and grinding leaf samples.

Reflectance spectroscopy can successfully characterize specific secondary metabolites in living plant tissue and provide detailed information on individual compounds within a constituent group. The ability to simultaneously measure multiple plant traits is a powerful attribute of reflectance spectroscopy because of its potential for in situ–in vivo field deployment using portable spectrometers. The suite of traits currently estimable, however, needs to expand to include specific secondary metabolites that play influential roles in ecosystem functioning if we are to advance the integration of chemical, landscape and ecosystem ecology.
Analysis of the association of HOTAIR single nucleotide polymorphism (rs920778) and risk of cervical cancer
Authors: Qiu Haifeng , Liu Qiuli , Li Juan , Wang Xiujuan , Wang Yuan , Yuan Zhongfu , Li Jing , Pei Dong‐Sheng 
Published: May 2016

We recently demonstrated that overexpression of HOTAIR (Hox transcript antisense intergenic RNA) was associated with tumor progression and radio‐resistance in human cervical cancer. Considering the single nucleotide polymorphism (SNP) rs920778 (C>T) could influence HOTAIR expression and cancer predisposition in other malignancies, we herein investigated the association between rs920778 status and cervical cancer susceptibility in a Chinese population. Using the specific TaqMan PCR assay, we genotyped rs920778 in 215 cervical cancer patients and 430 age‐matched healthy controls. As shown in our data, TT genotype of rs920778 was significantly correlated with the upregulation of HOTAIR (p = 0.008). Compared with the healthy control, TT genotype and T allele notably indicated a much higher risk of cervical cancer [TT genotype: odds ratio (OR) = 2.186, 95% confidence interval (CI) = 1.378–3.466, p = 0.003; T allele: OR = 1.556, 95% CI = 1.221–1.981]. In addition, we also found that the TT genotype of rs920778 was correlated with advanced tumor stage (p = 0.039), highly histological grade (p = 0.013), lympho node metastasis (p < 0.001) and positive infection of high risk HPV (p < 0.001). Among the patients who underwent concurrent chemo‐radiotherapy, TT genotype carriers present notably resistance to the combination of EBRT + ICBT + cisplatin (p = 0.023). In conclusion, we firstly reported that TT genotype of HOTAIR rs920778 was significantly associated with the cervical cancer susceptibility. Moreover, the TT genotype of rs920778 might be a potent prognostic marker in cervical cancer patients.