bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy
Authors: Tang Shirong , Luo Zhong , Qiu Xiaowei , Zhang Yanke , Lu Xi , huang Hao , Xu Zhongxiang , Xu Zucai 
Published: December 2017

AbstractGrowth hormone releasing hormone (GHRH) has recently been shown to increase the level of γ-aminobutyric acid (GABA) and activate GABA receptors (GABARs) in the cerebral cortex. GABA is an inhibitory neurotransmitter that can inhibit seizures. Does GHRH enhance the inhibitory effect of GABA to prevent epilepsy by increasing the GABA level and activating GABARs? In this study, patients with epilepsy and C57/BL6 mice with epilepsy induced by kainic acid (KA) or pentylenetetrazol (PTZ) served as the research subjects. Western blots were used to observe the differences in GHRH expression between the normal group and the epilepsy group, immunofluorescence was performed to explore the localization of GHRH in the brain, and coimmunoprecipitation was used to observe the interaction between GHRH and GABARs. GHRH expression was significantly increased in both patients with temporal lobe epilepsy (TLE) and in two mouse models induced by KA or PTZ compared with that in the normal groups (P < 0.05 or P < 0.01). GHRH was expressed in neurons in both humans and mice. Additionally, GHRH co-localized with presynaptic and postsynaptic sites of inhibitory neurons. Coimmunoprecipitation confirmed that GHRH interacted with GABAAα1 and GABAAβ2 + 3. GHRH may play an important role in inhibiting seizures by activating GABAARs.
A curated mammography data set for use in computer-aided detection and diagnosis research
Authors: Lee Rebecca Sawyer , Gimenez Francisco , Hoogi Assaf , Miyake Kanae Kawai , Gorovoy Mia , Rubin Daniel L. 
Published: December 2017

AbstractPublished research results are difficult to replicate due to the lack of a standard evaluation data set in the area of decision support systems in mammography; most computer-aided diagnosis (CADx) and detection (CADe) algorithms for breast cancer in mammography are evaluated on private data sets or on unspecified subsets of public databases. This causes an inability to directly compare the performance of methods or to replicate prior results. We seek to resolve this substantial challenge by releasing an updated and standardized version of the Digital Database for Screening Mammography (DDSM) for evaluation of future CADx and CADe systems (sometimes referred to generally as CAD) research in mammography. Our data set, the CBIS-DDSM (Curated Breast Imaging Subset of DDSM), includes decompressed images, data selection and curation by trained mammographers, updated mass segmentation and bounding boxes, and pathologic diagnosis for training data, formatted similarly to modern computer vision data sets. The data set contains 753 calcification cases and 891 mass cases, providing a data-set size capable of analyzing decision support systems in mammography.
Take-off engine particle emission indices for in-service aircraft at Los Angeles International Airport
Authors: Moore Richard H. , Shook Michael A. , Ziemba Luke D. , DiGangi Joshua P. , Winstead Edward L. , Rauch Bastian , Jurkat Tina , Thornhill Kenneth L. , Crosbie Ewan C. , Robinson Claire , Shingler Taylor J. , Anderson Bruce E. 
Published: December 2017

AbstractWe present ground-based, advected aircraft engine emissions from flights taking off at Los Angeles International Airport. 275 discrete engine take-off plumes were observed on 18 and 25 May 2014 at a distance of 400 m downwind of the runway. CO2 measurements are used to convert the aerosol data into plume-average emissions indices that are suitable for modelling aircraft emissions. Total and non-volatile particle number EIs are of order 1016–1017 kg−1 and 1014–1016 kg−1, respectively. Black-carbon-equivalent particle mass EIs vary between 175–941 mg kg−1 (except for the GE GEnx engines at 46 mg kg−1). Aircraft tail numbers recorded for each take-off event are used to incorporate aircraft- and engine-specific parameters into the data set. Data acquisition and processing follow standard methods for quality assurance. A unique aspect of the data set is the mapping of aerosol concentration time series to integrated plume EIs, aircraft and engine specifications, and manufacturer-reported engine emissions certifications. The integrated data enable future studies seeking to understand and model aircraft emissions and their impact on air quality.
The lithium-rotation connection in the 125 Myr-old Pleiades cluster
Authors: Bouvier J. , Barrado D. , Moraux E. , Stauffer J. , Rebull L. , Hillenbrand L. , Bayo A. , Boisse I. , Bouy H. , DiFolco E. , Lillo-Box J. , Morales Calderón M. 
Published: December 2017

Context. The evolution of lithium abundance over a star’s lifetime is indicative of transport processes operating in the stellar interior. Aims. We revisit the relationship between lithium content and rotation rate previously reported for cool dwarfs in the Pleiades cluster.
Methods. We derive new LiI 670.8 nm equivalent width measurements from high-resolution spectra obtained for low-mass Pleiades members. We combine these new measurements with previously published ones, and use the Kepler K2 rotational periods recently derived for Pleiades cool dwarfs to investigate the lithium-rotation connection in this 125 Myr-old cluster.
Results. The new data confirm the correlation between lithium equivalent width and stellar spin rate for a sample of 51 early K-type members of the cluster, where fast rotating stars are systematically lithium-rich compared to slowly rotating ones. The correlation is valid for all stars over the (J–Ks) color range 0.50–0.70 mag, corresponding to a mass range from about 0.75 to 0.90 M⊙, and may extend down to lower masses.
Conclusions. We argue that the dispersion in lithium equivalent widths observed for cool dwarfs in the Pleiades cluster reflects an intrinsic scatter in lithium abundances, and suggest that the physical origin of the lithium dispersion pattern is to be found in the pre-main sequence rotational history of solar-type stars.
A tail like no other
Authors: Volwerk Martin , Goetz Charlotte , Richter Ingo , Delva Magda , Ostaszewski Katharina , Schwingenschuh Konrad , Glassmeier Karl-Heinz 
Published: December 2017

Context. The Rosetta Plasma Consortium (RPC) magnetometer (MAG) data during the tail excursion in March–April 2016 are used to investigate the magnetic structure of and activity in the tail region of the weakly outgassing comet 67P/Churyumov–Gerasimenko (67P).
Aims. The goal of this study is to compare the large scale (near) tail structure with that of earlier missions to strong outgassing comets, and the small scale turbulent energy cascade (un)related to the singing comet phenomenon.
Methods. The usual methods of space plasma physics are used to analyse the magnetometer data, such as minimum variance analysis, spectral analysis, and power law fitting. Also the cone angle and clock angle of the magnetic field are calculated to interpret the data.
Results. It is found that comet 67P does not have a classical draped magnetic field and no bi-lobal tail structure at this late stage of the mission when the comet is already at 2.7 AU distance from the Sun. The main magnetic field direction seems to be more across the tail direction, which may implicate an asymmetric pick-up cloud. During periods of singing comet activity the propagation direction of the waves is at large angles with respect to the magnetic field and to the radial direction towards the comet. Turbulent cascade of magnetic energy from large to small scales is different in the presence of singing as without it.
A Novel 18F-Labeling Method for the Synthesis of [18F]-Piperidine-Containing Ligands as Potential PET Radiotracers for σ Receptors
Authors: Li Zibo , Wang Qiu , Ortiz Gerardo , Chansaenpak Kantapat , Wang Mengzhe , Ma Xiaofen , Wang Hui 
Published: December 2017

We report a novel 18F-labeling method for the preparation of 18F-containing piperidine derivatives. This method is demonstrated on the design and synthesis of 18F-labeled potential PET radiotracers of σ receptors for initial biological evaluations.1	Introduction2	Design and Synthesis of Novel [19F]-3 and [
19F]-3′
3	Radiosynthesis of Novel [18F]-3 and [18F]-3′
4	In vivo Uptake and Pharmacokinetics of [18F]-3 and [18F]-3′
5	Conclusion
Management of Destructive Colon Injuries after Damage Control Surgery
Authors: Prakash Priya , Symons William , Chamieh Jad 
Published: December 2017

AbstractAfter the World War II, fecal diversion became the standard of care for colon injuries, although medical, logistic, and technical advancements have challenged this approach. Damage control surgery serves to temporize immediately life-threatening conditions, and definitive management of destructive colon injuries is delayed until after appropriate resuscitation. The bowel can be left in discontinuity for up to 3 days before edema ensues, but the optimal repair window remains within 12 to 48 hours. Delayed anastomosis performed at the take-back operation or stoma formation has been reported with variable results. Studies have revealed good outcomes in those undergoing anastomosis after damage control surgery; however, they point to a subgroup of trauma patients considered to be “high risk” that may benefit from fecal diversion. Risk factors influencing morbidity and mortality rates include hypotension, massive transfusion, the degree of intra-abdominal contamination, associated organ injuries, shock, left-sided colon injury, and multiple comorbid conditions. Patients who are not suitable for anastomosis by 36 hours after damage control may be best managed with a diverting stoma. Failures are more likely related to ongoing instability, and the management strategy of colorectal injury should be based mainly on the patient's overall condition.
Whole Exon Deletion in the GFAP Gene Is a Novel Molecular Mechanism Causing Alexander Disease
Authors: Green Lydia , Berry Ian , Childs Anne-Marie , McCullagh Helen , Jose Sandhya , Warren Dan , Craven Ian , Camm Nick , Prescott Katrina , van der Knaap Marjo , Sheridan Eamonn , Livingston John 
Published: December 2017

AbstractAlexander disease (AD) is a leukodystrophy caused by heterozygous mutations in the gene encoding the glial fibrillary acidic protein (GFAP). Currently, de novo heterozygous missense mutations in the GFAP gene are identified in over 95% of patients with AD. However, patients with biopsy-proven AD have been reported in whom no GFAP mutation has been identified. We report identical twin boys presenting in infancy with seizures and developmental delay in whom MR appearances were suggestive of AD with the exception of an unusual, bilateral, arc of calcification at the frontal white–gray junction. Initial mutation screening of the GFAP gene did not identify a mutation. Whole exome sequencing in both brothers revealed a de novo heterozygous in-frame deletion of the whole of exon 5 of the GFAP gene. Mutations in the GFAP gene are thought to result in a toxic effect of mutant GFAP disrupting the formation of the normal intermediate filament network and resulting in Rosenthal fiber formation, which has hitherto not been linked to exonic scale copy number variants in GFAP. Further studies on mutation negative AD patients are warranted to determine whether a similar mechanism underlies their disease.
Comparison of Cervicovaginal Cytopathological Samples Collected in Basic Health Units and in Private Clinics in the Midwest of Santa Catarina
Authors: Dallazem Bárbara , Dambrós Bibiana Paula , Gamba Conrado de Oliveira , Perazzoli Marcelo , Kirschnick Alexandre 
Published: December 2017

Objective To compare the quality of cervicovaginal samples obtained from basic health units (BHUs) of the Unified Health System (SUS) and those obtained from private clinics to screen precursor lesions of cervical cancer.
Methods It was an intervention study whose investigated variables were: adequacy of the samples; presence of epithelia in the samples, and cytopathological results. A total of 940 forms containing the analysis of the biological samples were examined: 470 forms of women attended at BHUs of the SUS and 470 forms of women examined in private clinics in January and February of 2016.
Results All the unsatisfactory samples were collected at BHUs and corresponded to 4% of the total in this sector (p < 0.0001). There was a higher percentage of samples containing only squamous cells in the SUS (43.9%). There was squamocolumnar junction (SJC) representativeness in 82.1% of the samples from the private clinics (p < 0.0001). Regarding negative results for intraepithelial lesions and/or malignancies, the percentages obtained were 95.9% and 99.1% (p < 0.0049) in the exams collected in the private system and SUS, respectively. Less serious lesions corresponded to 0.89% of the samples from the SUS and 2.56% of the tests from the private sector; more serious lesions were not represented in the samples obtained from BHUs, whereas the percentage was 1.49% in private institutions.
Conclusion Unsatisfactory cervical samples were observed only in exams performed at the SUS. There is a need for guidance and training of professionals who perform this procedure to achieve higher reliability in the results and more safety for women who undergo this preventive test.
Staging des Lungenkarzinoms nach der revidierten TNM-Klassifikation
Authors: Niehoff Julius , Diederich Stefan , Höink Anna 
Published: December 2017

ZusammenfassungDas Lungenkarzinom ist eine der häufigsten Krebserkrankungen des Menschen. Die komplexen und häufig multimodalen Therapiekonzepte dieses Krankheitsbildes setzen eine exakte Klassifikation jedes Tumors anhand von Tumorgröße (T), Lymphknotenstatus (N) und Fernmetastasen (M) voraus. Die TNM-Klassifikation für Lungentumoren ist von der International Association for the Study of Lung Cancer (IASLC) kürzlich in der 8. Auflage veröffentlicht worden.
Neurodevelopmental Outcome in Children With Single Ventricle After Total Cavopulmonary Connection
Authors: Vahsen Nicole , Bröder Arndt , Hraska Viktor , Schneider Martin 
Published: December 2017

Abstract
Background The purpose of the present study was to assess a broad range of neuropsychological outcome variables in children with functionally single ventricle hearts after a total cavopulmonary connection and to examine potential risk factors for impaired neurodevelopment.
Patients & Method A total of 104 patients aged 2 to 20 years underwent follow-up standardized psychological testing, including measures of intelligence, motor function, visuospatial abilities, behavioural outcome and health-related quality of life.
Results With a mean fluid intelligence score of 93.0 and a mean crystallized intelligence score of 92.3, patients scored significantly lower on tests of intelligence compared to the general population (p<0.001). Reduced motor function was found in 34% of the patients (p<0.001), impaired visuospatial abilities in 51%; parents reported significantly more behavioural problems (p<0.001). There was no difference in the self-reported quality of life compared to the general population. Risk factors for reduced fluid intelligence were deep hypothermic circulatory arrest times (p=0.03) and complications causing suboptimal brain perfusion prior to the total cavopulmonary connection (e. g. seizures; p=0.04).
Conclusions Patients with functionally single ventricle hearts palliated with a total cavopulmonary connection are at an increased risk of neurodevelopmental delays and behavioural disorders. Nevertheless, they adapt well in terms of quality of life. Early diagnostics and interventions are necessary when developmental delays are suspected.
Code of Conduct Digital Health der Deutschen Diabetes Gesellschaft
Authors: Müller-Wieland Dirk , Ickrath Manuel 
Published: December 2017

ZUSAMMENFASSUNGDie „digitale Transformation“ verändert alle Gesellschafts- und Lebensbereiche – und damit auch die Medizin und Diabetologie. Eine medizinisch-wissenschaftliche Fachgesellschaft, wie die Deutsche Diabetes Gesellschaft (DDG), sollte den wissenschaftlich und ethisch basierten „medizinischen Standard“ für diesen primär durch Technik getriebenen Wandel formulieren. Forderungen, die sich daraus ergeben, müssen erkennbar zusammengefasst werden und damit einen „Handlungsrahmen“ für Akteure im Gesundheitswesen definieren: Dies soll der „Code of Conduct Digital Health“ (CoC DH) der DDG leisten.
Herausforderung Leichte Sprache
Authors: Rosenkötter Nicole , Borrmann Brigitte 
Published: December 2017

Zusammenfassung
Hintergrund und Methoden In der Behindertenrechtskonvention der Vereinten Nationen wird u. a. das Recht auf den Zugang zu Informationen festgelegt. Texte sollen in zugänglichen Formaten und Technologien für Menschen mit unterschiedlichen Arten der Behinderung verfügbar gemacht werden. Für Menschen mit Lese- und Lernschwierigkeiten stellt v. a. die Sprache eine Barriere dar. Aus diesem Grund wurden Teile des aktuellen nordrhein-westfälischen Landesgesundheitsberichts in Leichte Sprache übersetzt.Die Übersetzung wurde durch ein professionelles Übersetzungsbüro in Kooperation mit einer Prüfgruppe, zusammengesetzt aus einer Gruppe von Menschen mit Lernschwierigkeiten, sowie dem Landeszentrum Gesundheit NRW (LZG.NRW) durchgeführt. Hierbei zeigten sich aus Sicht der Gesundheitsberichterstattung verschiedene Übersetzungsprobleme. Deren Art und die gewählten Lösungsansätze werden in diesem Artikel näher beschrieben.
Ergebnisse Insgesamt wurden 3 Problembereiche im Übersetzungsprozess besonders deutlich: (1) (Hohe) Zahlen und Raten sind Hauptbestandteile der Gesundheitsberichterstattung, in der Leichten Sprache sollten diese jedoch vermieden werden. (2) Die Beschreibung der Altersstandardisierung und die damit zusammenhängenden Effekte sind schwer in Leichte Sprache zu fassen. (3) Das Finden der richtigen Balance zwischen Einflüssen des individuellen Lebensstils und weiterer Gesundheitsdeterminanten sowie die Entwicklung einer nicht diskriminierenden Ausdrucksweise bei der Beschreibung von sozialen Einflussfaktoren stellen besondere Herausforderungen dar.Den Übersetzungsproblemen wurde folgendermaßen begegnet: (1) Zahlen und Raten wurden in der Übersetzung vermieden. Wenn dies nicht möglich war, wurden grobe Anteile benannt, die in der Einleitung anhand einer Infografik visualisiert wurden. (2) In der Übersetzung wurden zeitliche Entwicklungen nur in wenigen Einzelfällen benannt. Hierbei wurde die Entwicklung von rohen Raten dargestellt und, falls nötig, wurden Erklärungen (z. B. demografischer Wandel) in Leichter Sprache hinzugefügt. Bei Geschlechterunterschieden mit einer unterschiedlichen Ausprägung in der rohen und altersstandardisierten Rate wurden die altersstandardisierte Verteilung beschrieben. (3) Die Relativierung von plakativen Darstellungen bezüglich des Einflusses sozialer Gesundheitsdeterminanten und die Einbeziehung von Handlungsspielräumen der Verhältnisprävention mussten erkannt und bewusst in den Text eingearbeitet werden.
Schlussfolgerung Die Übersetzung eines Gesundheitsberichts in Leichter Sprache ist ein komplexer und langwieriger Prozess. Eine gute Kooperation zwischen Übersetzern, Prüfgruppen und der Gesundheitsberichterstattung ist für das Gelingen zwingend erforderlich.
Pilzberatung als Aufgabe des Öffentlichen Gesundheitsdienstes (ÖGD) in Mecklenburg-Vorpommern
Authors: Duty Oliver 
Published: December 2017

ZusammenfassungDie Beratung der Bürger über die Essbarkeit von Pilzen erfolgt in Mecklenburg-Vorpommern durch Pilzberater, die im Auftrag des Öffentlichen Gesundheitsdienstes tätig sind. Land und Kommune teilen sich dabei die Aufgaben. Wie diese Arbeitsteilung funktioniert, welche rechtlichen Grundlagen existieren und welche Aufgaben durch die Verantwortlichen wahrgenommen werden, ist Bestandteil dieser Arbeit.
Purse-string transoral outlet reduction (TORe) is effective at inducing weight loss and improvement in metabolic comorbidities after Roux-en-Y gastric bypass
Authors: Jirapinyo Pichamol , Kröner Paul , Thompson Christopher 
Published: December 2017

Abstract
Background and study aims Transoral outlet reduction (TORe), performed using a traditional interrupted or a recently described purse-string suture pattern, is effective at inducing short- and mid-term weight loss in patients with weight regain after Roux-en-Y gastric bypass (RYGB). We aimed to determine the technical feasibility and safety of purse-string TORe and to assess its impact on weight and metabolic profiles.
Patients and methods RYGB patients undergoing purse-string TORe were included. The gastrojejunal anastomosis (GJA) was ablated using argon plasma coagulation or dissected using endoscopic submucosal dissection. A suture was used to place stitches around the GJA in a continuous ring fashion. The suture was cinched over a balloon (8 – 12 mm). The primary outcome was technical feasibility. Secondary outcomes were the percentage of total body weight lost (%TWL), adverse events, impact on comorbidities, and predictors of weight loss.
Results 252 RYGB patients underwent 260 purse-string TORes. They had regained 52.6 ± 46.4 % of lost weight and weighed 107.6 ± 24.6 kg. The technical success rate was 100 %. At 6 and 12 months, %TWL was 9.6 ± 6.3 and 8.4 ± 8.2. Two serious adverse events (0.8 %) occurred: gastrointestinal bleeding and GJA stenosis. At 12 months, blood pressure, hemoglobin A1c, and ALT had improved. Prior weight regain was associated with %TWL at 12 months (β = 0.07, P = 0.007) after controlling for BMI, pouch size, and number of purse-string rings.
Conclusion Purse-string TORe to treat weight regain after RYGB is technically feasible and safe. Additionally, it is associated with improvement in weight and comorbidity profiles up to 12 months post-procedure.
Psychosomatosen und die Holy seven
Authors: Schmid Eva 
Published: December 2017

SummaryAnfang der 1950er-Jahre beschrieb der Mitbegründer der psychosomatischen Medizin Franz Alexander, ein Arzt und Psychoanalytiker, sieben klassische psychosomatische Erkrankungen. Er nahm an, dass „spezifische Konflikte“ in großem Maße verantwortlich sind für deren Entstehung. Später wurden diese Erkrankungen als die sogenannten „Holy seven“ bekannt.
Auf dem Weg zum Closed-Loop – Ziel und Realität
Authors: Biester Torben , Danne Thomas , Kordonouri Olga 
Published: December 2017

ZusammenfassungEine vollständig automatisierte Insulindosierung ist der Wunschtraum von Behandlern und Patienten mit Typ-1-Diabetes. Schon jetzt können sensorunterstützte Insulinpumpen reduzierend in die Insulinzufuhr eingreifen. Ziel von Forschungsarbeiten ist es, in das Zusammenspiel aus Pumpe und Sensor einen Algorithmus zu integrieren, der die automatische Abgabe des Insulins im Sinne eines vollständigen Regelkreislaufs (Closed-Loop) reguliert.
Flugangst: Die Muskeln entspannen in wenigen Sekunden
Authors: Krefting R , Bayaz A 
Published: December 2017

SummaryAngst zuzulassen muss nicht bedeuten, bei der Panik zu enden. Wir können lernen das Angstgeschehen zu beeinflussen, es bis zu einem gewissen Grad zu kontrollieren und den Aufschaukelungsprozess zu verhindern – und staunend wahrnehmen, dass die übrig gebliebene Angst durchaus zu ertragen ist und uns nicht länger zur Hilflosigkeit verurteilt. Angst, also auch Flugangst, geht einher mit Verspannungen der Muskeln.
RETRACTED: Analysis and Research on Spatial Data Storage Model Based on Cloud Computing Platform
Authors: Hu Yong 
Published: December 2017

Abstract
In this paper, the data processing and storage characteristics of cloud computing are analyzed and studied. On this basis, a cloud computing data storage model based on BP neural network is proposed. In this data storage model, it can carry out the choice of server cluster according to the different attributes of the data, so as to complete the spatial data storage model with load balancing function, and have certain feasibility and application advantages.