bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary Leiomyosarcoma of the Pancreas—a Case Report and a Comprehensive Review
Authors: Søreide Jon Arne , Undersrud Erling Sandøy , Al-Saiddi Mohammed S. S. , Tholfsen Tore , Søreide Kjetil 
Published: September 2016

Abstract
Purpose
Primary mesenchymal tumors of the pancreas are rare, with leiomyosarcomas the most encountered entities among the pancreatic sarcomas. With few exceptions, single case reports published over the last six decades constitute the entire scientific literature on this topic. Thus, evidence regarding clinical decision-making is scant.

Methods
Based on a case report and an extensive literature search in PubMed, we discuss the clinical aspects and current management of this rare malignancy.

Results
We identified only two papers with more than a single case presentation; these institutional patient series were limited to five and nine patients. Additionally, a few papers sought to summarize the individual case reports published in the English and/or Chinese language. The clinical presentation is rather non-specific. Moreover, modern imaging modalities are insufficiently accurate to diagnose leiomyosarcoma of the pancreas. Treatment goals include a complete resection with free margins. Proper morphologic examination using immunohistochemistry and the application of a grading system are clinically important for prognostication. The efficacy of adjuvant treatments has not been established.

Conclusion
Primary pancreatic leiomyosarcoma is extremely rare, and the scientific literature is primarily based on single case reports. Conclusions on management and prognosis should be drawn with caution. A multidisciplinary team consultation is warranted to discuss a thorough individual treatment plan based on the available scientific literature, despite its low evidence level.
MYH9-related disorder, a probable May-Hegglin anomaly case series
Authors: Kamath Vandana , Gnanasekaran Kiruthiga Kala , Mammen Joy 
Published: September 2016

Objective/background:
May-Hegglin anomaly (MHA) is a rare familial bleeding disorder characterized by a triad of thrombocytopenia, giant platelets, and Döhle-like inclusion bodies within the leukocytes. The clinical spectrum as well as the pathophysiology of this entity is not well defined. The objective of this work is to present a series of three cases of MHA diagnosed in our hospital, where the patients presented with variable bleeding manifestations, thrombocytopenia, and giant platelets.

Materials and Methods:
We studied three cases of possible MHA. In addition to the clinical examination, complete hemogram, and peripheral blood smear examination, these patients were also subjected to coagulation studies. Although bleeding symptoms varied among these patients, platelet aggregation tests with various agonists showed a normal response.

Results:
Consistent findings of this entity noted in our patients were mild-to-moderate thrombocytopenia, giant platelets, and Döhle-like inclusions within the leukocytes.

Conclusion:
A diagnosis of MHA could be made based on a thorough peripheral blood smear examination, which also helps to avoid a misdiagnosis of immune thrombocytopenia.
Regional differences in the prevalence of underweight, overweight and obesity among 13-year-old adolescents in Greece
Authors: Poulimeneas Dimitrios , Grammatikopoulou Maria G. , Dimitrakopoulos Leonidas , Kotsias Emma , Gerothanasi Dina , Kiranas Efstratios R. , Tsigga Maria 
Published: September 2016

Background and objectives:
To assess regional differences in the weight status and abdominal obesity among 13-year-old Greek adolescents.

Design and setting:
Cross-sectional, nationwide study in Greece.

Patients and methods:
A representative sample of 4833 13-year-old adolescents (50.7% boys) was recruited throughout the nine regional districts of Greece from 2010 to 2012. Basic anthropometry measurements (weight, height, and waist circumference) were obtained. Abdominal obesity and weight status were assessed according to the International Obesity Task Force criteria.

Results:
The majority of the sample had a healthy body weight (60.3%), 4.1% were underweight, 27.2% were overweight, and 8.5% were obese. For boys, the highest prevalence of underweight was recorded in Epirus, normal body weight on the Ionian Islands, overweight in Central Greece and Macedonia, and obesity on the Ionian Islands. Among girls, the highest underweight prevalence was on the Ionian Islands, normal body weight in Macedonia, overweight in Central Greece and Macedonia, and obesity in Crete. Abdominal obesity affected 12.9% of the sample, with the greatest prevalence among Cretan boys and Thracian girls. Additionally, residing on the Greek islands was associated with a higher prevalence of central adiposity.

Conclusion:
Greek 13-year-old adolescents who are subjected to geographical changes exhibit high obesity and abdominal obesity rates. This study provides evidence to design regionally tailored interventions that aim to tackle and prevent the disease among the nine regional districts in Greece.
Local conduction during acute myocardial infarction in rats: Interplay between central sympathetic activation and endothelin
Authors: Kolettis Theofilos M. , Kontonika Marianthi , La Rocca Vassilios , Vlahos Antonios P. , Baltogiannis Giannis G. , Kyriakides Zenon S. 
Published: September 2016

AbstractWe investigated the effects of autonomic dysfunction and endothelin on local conduction and arrhythmogenesis during myocardial infarction. We recorded ventricular tachyarrhythmias, monophasic action potentials, and activation sequences in wild‐type and ETB‐deficient rats displaying high endothelin levels. Central sympathetic inputs were examined after clonidine administration. Clonidine mitigated early and delayed arrhythmogenesis in ETB‐deficient and wild‐type rats, respectively. The right ventricular activation delay increased in clonidine‐treated ETB‐deficient rats and slightly decreased in wild‐type rats. The left ventricular voltage rise decreased in all groups, whereas the activation delay increased mainly in clonidine‐treated ETB‐deficient rats. Central sympathetic activation and endothelin modulate ischemia‐induced arrhythmogenesis. Ischemia alters excitability, whereas endothelin impairs local conduction, an action partly counterbalanced by central sympathetic activity.
San Gregorio Magno, viaje entre memorias e identidad. Estudio socioantropológico de una comunidad del Mezzogiorno italiano
Authors: Re Arianna 
Published: September 2016

Historias de vida y biografías guían el viaje de la memoria y sus procesos, especialmente a través de la aculturación y los cambios que ha provocado. En un ciclo anual de rituales y fiestas populares, este estudio recorre la vida, las costumbres y el contexto social de la comunidad, explorando así la supuesta continuidad de las tradiciones que redefinen en el tiempo las identidades y los valores de pertenencia.
Modelling the response of ice shelf basal melting to different ocean cavity environmental regimes
Authors: Gwyther David E. , Cougnon Eva A. , Galton-Fenzi Benjamin K. , Roberts Jason L. , Hunter John R. , Dinniman Michael S. 
Published: September 2016

ABSTRACTWe present simulation results from a version of the Regional Ocean Modeling System modified for ice shelf/ocean interaction, including the parameterisation of basal melting by molecular diffusion alone. Simulations investigate the differences in melting for an idealised ice shelf experiencing a range of cold to hot ocean cavity conditions. Both the pattern of melt and the location of maximum melt shift due to changes in the buoyancy-driven circulation, in a different way to previous studies. Tidal forcing increases both the circulation strength and melting, with the strongest impact on the cold cavity case. Our results highlight the importance of including a complete melt parameterisation and tidal forcing. In response to the 2.4°C ocean warming initially applied to a cold cavity ice shelf, we find that melting will increase by about an order of magnitude (24 × with tides and 41 × without tides).
Comparison of trimethoprim-sulfamethoxazole versus placebo for uncomplicated
skin abscesses
Authors: Gottlieb Michael 
Published: September 2016

Clinical question
In patients with uncomplicated abscesses receiving incision and drainage,
does the addition of trimethoprim-sulfamethoxazole result in improved clinical
resolution at 7 to 14 days after treatment when compared with placebo?

Article chosen
Talan DA, Mower WR, Krishnadasan A, et al. Trimethoprim-sulfamethoxazole
versus placebo for uncomplicated skin abscess. N Engl J
Med 2016;374(9):823-32.

Objective
The primary objective of this study was to compare the clinical cure rates
at 7 to 14 days after the end of the treatment period among patients receiving
either trimethoprim-sulfamethoxazole (TMP-SMX) or placebo. Secondary outcomes
included composite cure; surgical drainage procedures; change in erythema size;
presence of swelling, induration, or tenderness; invasive infections; skin
infections at the same site and different sites; hospitalizations; similar
infections in household contacts; days missed from normal activities; days
missed from school or work; and days of analgesic use.
Pandemic H1N1 Vaccination and Incidence of Acute Disseminated Encephalomyelitis in Manitoba
Authors: Jackson Alan C. , Mostaço-Guidolin Luiz C. , Sinnock Hasantha , Bozat-Emre Songul , Routledge Michael , Mahmud Salaheddin M. 
Published: September 2016

AbstractBackground: An increased incidence of hospital admissions coded as acute disseminated encephalomyelitis (ADEM) was noted in Winnipeg, Manitoba, Canada, during the second wave of the influenza pandemic from October 2009 to March 2010. However, it was not clear whether this was due to heightened awareness of potential neurological complications of influenza or influenza vaccination or an actual increase in the number of cases. Methods: We extracted data from the charts of 139 patients hospitalized with an International Classification of Diseases-10 discharge code indicating ADEM (G04.0) or unspecified noninfectious encephalitis or myelitis (G04.8, G04.9) between January 2006 and December 2012. Clinical and laboratory data were reviewed by a neurologist, and diagnoses were determined using the Brighton criteria. Results: Over the entire study period, there were 22 cases of ADEM. During the peak pandemic period (April-December 2009), seven patients were hospitalized with ADEM, corresponding to a rate of 7.8/million/year; 4.7 (95% confidence interval: 1.9-11.4) times higher than the rate before or after the pandemic period. Only one patient with ADEM had received the monovalent A(H1N1)pdm09 vaccine within 12 weeks of hospitalization. Conclusions: We have found an increased incidence of ADEM during the pandemic period that may be related, at least in part, to the increased incidence of influenza during that period. However, there was no temporal relationship with the administration of A(H1N1)pdm09 or seasonal influenza vaccines. Our study provides reassurance that use of these vaccines was not associated with increased risk of ADEM.
PEER DISAGREEMENT AND THE DUNNING-KRUGER EFFECT
Authors: Wiland Eric 
Published: September 2016

ABSTRACTI argue that recent evidence about our self-serving biases has radical implications for the epistemology of peer disagreement. I conclude that much of the time when you are disagreeing with someone you regard as your epistemic peer, you should not merely move halfway to her judgment, as The Equal Weight View has it. That is not conciliatory enough. Surprisingly often, you should be at least weakly confident that you are wrong, and that your disputant is right.
A Model-Based Strategy to Control the Spread of Carbapenem-Resistant Enterobacteriaceae: Simulate and Implement
Authors: DalBen Mirian de Freitas , Teixeira Mendes Elisa , Moura Maria Luisa , Abdel Rahman Dania , Peixoto Driele , Alves dos Santos Sania , Barcelos de Figueiredo Walquiria , Vitale Mendes Pedro , Utino Taniguchi Leandro , Bezerra Coutinho Francisco Antonio , Massad Eduardo , Levin Anna Sara 
Published: September 2016

OBJECTIVETo reduce transmission of carbapenem-resistant Enterobacteriaceae (CRE) in an intensive care unit with interventions based on simulations by a developed mathematical model.DESIGNBefore-after trial with a 44-week baseline period and 24-week intervention period.SETTINGMedical intensive care unit of a tertiary care teaching hospital.PARTICIPANTSAll patients admitted to the unit.METHODSWe developed a model of transmission of CRE in an intensive care unit and measured all necessary parameters for the model input. Goals of compliance with hand hygiene and with isolation precautions were established on the basis of the simulations and an intervention was focused on reaching those metrics as goals. Weekly auditing and giving feedback were conducted.RESULTSThe goals for compliance with hand hygiene and contact precautions were reached on the third week of the intervention period. During the baseline period, the calculated R0 was 11; the median prevalence of patients colonized by CRE in the unit was 33%, and 3 times it exceeded 50%. In the intervention period, the median prevalence of colonized CRE patients went to 21%, with a median weekly Rn of 0.42 (range, 0–2.1).CONCLUSIONSThe simulations helped establish and achieve specific goals to control the high prevalence rates of CRE and reduce CRE transmission within the unit. The model was able to predict the observed outcomes. To our knowledge, this is the first study in infection control to measure most variables of a model in real life and to apply the model as a decision support tool for intervention.Infect Control Hosp Epidemiol2016;1–8
Design and Reliability Assessment of Novel 3D-IC Packaging
Authors: Su Y.-F. , Chiang K.-N. , Liang Steven Y. 
Published: September 2016

AbstractPresently, physical limitations are restricting the development of the microelectronic industry driven by Moore's law. To achieve high-performance, small form factor, and lightweight applications, new electronic packaging methods have exceeded Moore's law. This research proposes a double-chip stacking structure in an embedded fan-out wafer-level packaging with double-sided interconnections. The overall reliability of the solder joints and redistributed lines is assessed through finite element analysis. The application of soft lamination material and selection of a carrier material whose coefficient of thermal expansion (CTE) is close to that of the printed circuit board can effectively enhance the reliability of solder joints over more than 1,000 cycles. A trace/pad junction whose direction is parallel to the major direction of the CTE mismatch is recommended, and the curved portion of trace lines can absorb the expansion of metal lines and filler material. Design-on-simulation methodology is necessary to develop novel packaging structures in the electronic packaging industry.
The Australian Square Kilometre Array Pathfinder: Performance of the Boolardy Engineering Test Array
Authors: McConnell D. , Allison J. R. , Bannister K. , Bell M. E. , Bignall H. E. , Chippendale A. P. , Edwards P. G. , Harvey-Smith L. , Hegarty S. , Heywood I. , Hotan A. W. , Indermuehle B. T. , Lenc E. , Marvil J. , Popping A. , Raja W. , Reynolds J. E. , Sault R. J. , Serra P. , Voronkov M. A. , Whiting M. , Amy S. W. , Axtens P. , Ball L. , Bateman T. J. , Bock D. C.-J. , Bolton R. , Brodrick D. , Brothers M. , Brown A. J. , Bunton J. D. , Cheng W. , Cornwell T. , DeBoer D. , Feain I. , Gough R. , Gupta N. , Guzman J. C. , Hampson G. A. , Hay S. , Hayman D. B. , Hoyle S. , Humphreys B. , Jacka C. , Jackson C. A. , Jackson S. , Jeganathan K. , Joseph J. , Koribalski B. S. , Leach M. , Lensson E. S. , MacLeod A. , Mackay S. , Marquarding M. , McClure-Griffiths N. M. , Mirtschin P. , Mitchell D. , Neuhold S. , Ng A. , Norris R. , Pearce S. , Qiao R. Y. , Schinckel A. E. T. , Shields M. , Shimwell T. W. , Storey M. , Troup E. , Turner B. , Tuthill J. , Tzioumis A. , Wark R. M. , Westmeier T. , Wilson C. , Wilson T. 
Published: September 2016

AbstractWe describe the performance of the Boolardy Engineering Test Array, the prototype for the Australian Square Kilometre Array Pathfinder telescope. Boolardy Engineering Test Array is the first aperture synthesis radio telescope to use phased array feed technology, giving it the ability to electronically form up to nine dual-polarisation beams. We report the methods developed for forming and measuring the beams, and the adaptations that have been made to the traditional calibration and imaging procedures in order to allow BETA to function as a multi-beam aperture synthesis telescope. We describe the commissioning of the instrument and present details of Boolardy Engineering Test Array’s performance: sensitivity, beam characteristics, polarimetric properties, and image quality. We summarise the astronomical science that it has produced and draw lessons from operating Boolardy Engineering Test Array that will be relevant to the commissioning and operation of the final Australian Square Kilometre Array Path telescope.
Precise Orbital Solutions for KEPLER Eclipsing Binaries of W UMa Type Showing Total Eclipses
Authors: Şenavcı H. V. , Doğruel M. B. , Nelson R. H. , Yılmaz M. , Selam S. O. 
Published: September 2016

AbstractWe aim to discover the accuracy of photometric mass ratios (qph) determined for eclipsing binary stars, in the case of the system having at least one ‘flat bottom’ as a minimum profile, as well as the accuracy of data used in that sense. Within this context, we present the results of two-dimensional grid search (q – i) for some W UMa-type eclipsing binaries showing total eclipses, based on the high precision photometric data provided by the KEPLER Mission. The radial velocity data obtained for KIC10618253 in this study, enables us to compare both qph and the corresponding spectroscopic mass ratio (qsp) values. The results indicate that the high precision photometric data for overcontact eclipsing binaries showing total eclipses allow us to obtain the photometric mass ratios as accurate as the spectroscopic values.
Successfully Dating Rock Art in Southern Africa Using Improved Sampling Methods and New Characterization and Pretreatment Protocols
Authors: Bonneau A , Staff R A , Higham T , Brock F , Pearce D G , Mitchell P J 
Published: September 2016

AbstractWorldwide, dating rock art is difficult to achieve because of the frequent lack of datable material and the difficulty of removing contamination from samples. Our research aimed to select the paints that would be the most likely to be successfully radiocarbon dated and to estimate the quantity of paint needed depending on the nature of the paint and the weathering and alteration products associated with it. To achieve this aim, a two-step sampling strategy, coupled with a multi-instrument characterization (including SEM-EDS, Raman spectroscopy, and FTIR spectroscopy analysis) and a modified acid-base-acid (ABA) pretreatment, was created. In total, 41 samples were dated from 14 sites in three separate regions of southern Africa. These novel protocols ensure that the14C chronology produced was robust and could also be subsequently applied to different regions with possible variations in paint preparation, geology, weathering conditions, and contaminants.
Speed Dating: A Rapid Way to Determine the Radiocarbon Age of Wood by EA-AMS
Authors: Sookdeo Adam , Wacker Lukas , Fahrni Simon , McIntyre Cameron P , Friedrich Michael , Reinig Frederick , Nievergelt Daniel , Tegel Willy , Kromer Bernd , Büntgen Ulf 
Published: September 2016

AbstractRadiocarbon measurements in tree rings can be used to estimate atmospheric 14C concentration and thereby used to create a 14C calibration curve. When wood is discovered in construction sites, rivers, buildings, and lake sediments, it is unclear if the wood could fill gaps in the 14C calibration curve or if the wood is of historical interest until the age is determined by dendrochronology or 14C dating. However, dendrochronological dating is subjected to many requirements and 14C dating is costly and time consuming, both of which can be frivolous endeavors if the samples are not in the age range of interest. A simplified 14C dating technique, called Speed Dating, was thus developed. It can be used to quickly obtain 14C ages as wood samples are neither chemically treated nor graphitized. Instead, wood is combusted in an elemental analyzer (EA) and the CO2 produced is carried into an accelerator mass spectrometer (AMS) with a gas ion source. Within a day, 75 samples can be measured with uncertainties between 0.5–2% depending on the age, preservation, and contaminants on the material and Speed Dating costs about one-third of conventional AMS dates.
The introduction of emergency cricothyroidotomy simulation training in Zimbabwe contributed to the saving of two lives
Authors: Avnstorp M B , Jensen P V F , Dzongodza T , Matinhira N , Chidziva C , Melchiors J , Von Buchwald C 
Published: September 2016

AbstractBackground:In developing countries with limited access to ENT services, performing emergency cricothyroidotomy in patients with upper airway obstruction may be a life-saving last resort. An established Danish–Zimbabwean collaboration of otorhinolaryngologists enrolled Zimbabwean doctors into a video-guided simulation training programme on emergency cricothyroidotomy. This paper presents the positive effect of this training, illustrated by two case reports.Case reports:A 56-year-old female presented with upper airway obstruction due to a rapidly progressing infectious swelling of the head and neck progressing to cardiac arrest. Cardiopulmonary resuscitation was initiated and a secure surgical airway was established via an emergency cricothyroidotomy, saving the patient. A 70-year-old male presented with upper airway obstruction secondary to intubation for an elective procedure. When extubated, the patient exhibited severe stridor followed by respiratory arrest. Re-intubation attempts were unsuccessful and emergency cricothyroidotomy was performed to secure the airway, preserving the life of the patient.Conclusion:Emergency cricothyroidotomy training should be considered for all surgeons, anaesthetists and, eventually, emergency and recovery room personnel in developing countries. A video-guided simulation training programme on emergency cricothyroidotomy in Zimbabwe proved its value in this regard.
Temporal variability in copepod gut pigments over the central western continental shelf of India
Authors: D'souza Analiza Maria , Gauns Mangesh Uttam 
Published: September 2016

The Indian Western continental shelf (IWCS) is amongst the most productive regions of the world, being noteworthy for upwelling (south-west monsoon) and downwelling (north-east monsoon) that tunes the water biogeochemistry. The present study provides baseline information on temporal variation of in situ copepod gut pigments from IWCS. The copepods were collected between November 2011 and October 2013 and gut pigment contents and composition were estimated using the gut fluorescence method. Results revealed that copepods procured high gut pigment content in monsoon that coincided with ambient water pigment credited to discrete upwelling. Fluorometric analyses of copepod orders revealed presence of gut chlorophyll a (Chl a) throughout the study with highest gut Chl a (0.31 ± 0.25 ng copepod−1; N = 21) and total gut pigments (2.01 ± 2.15 ng copepod−1; N = 21) recorded in Calanoida. Consecutively, Calanoida and Poecilostomatoida chiefly consumed autotrophic biomass that was evident from presence of canthaxanthin and astaxanthin as dominant gut pigments. Interestingly, the marker pigment of Cryptophyceae was present only in Calanoida during monsoon and post-monsoon. Collectively these results conclude that copepods predominantly showed omnivory with discrete temporal variability by grazing upon autotrophic biomass that in turn probably supports the fishery.