bluuebunny/crossref_metadata_2025_split huggingface dataset:
Which Classification of Cavernous Sinus Syndrome is Better - Ishikawa or Jefferson? A Prospective Study of 73 Patients
Authors: Bhatkar Sanat , Goyal Manoj Kumar , Takkar Aastha , Modi Manish , Mukherjee Kanchan K. , Singh Paramjeet , Radotra Bishan Das , Singh Ramandeep , Lal Vivek 
Published: December 2016

ABSTRACT
Introduction: Ishikawa and Jefferson are the two most commonly used systems used for the classification of cavernous sinus syndrome (CSS). However, relative utilities of these two classification systems have not been evaluated in detail in developing countries. In this study, we compared relative utilities of these two classification schemes in the evaluation of CSS. Objective: To compare the utility of Jefferson and Ishikawa classifications in the evaluation of CSS. Patients and Methods: A total of 73 consecutive patients of CSS were prospectively classified using either Ishikawa or Jefferson classification and relative utility of these two classification schemes in determining etiology of CSS was compared. Results: While only 46.6% of patients could be classified using Jefferson classification, 95.5% of patients could be classified using Ishikawa scheme. CSS was classified as anterior, middle, and posterior in 17.8%, 21.9%, and 8.2% of patients, respectively, as per the Jefferson classification. As per the Ishikawa classification, 37% of patients each showed anterior and posterior CSS, 16.4% showed middle CSS, whereas 4.1% had whole CSS. Middle CSS was significantly associated with the presence of fungal infections (P = 0.045) as per Jefferson classifications, and anterior CSS was significantly associated with a vascular etiology (P = 0.005) as per Ishikawa classification. Overall, inflammatory causes were the most common cause for anterior CSS, while tumors accounted for maximum cases of posterior CSS. Conclusion: Although more number of patients could be classified using Ishikawa classification, there was no advantage of Ishikawa classification over Jefferson with regard to determination of etiology of CSS.
Use of Frameless Stereotactic Neuronavigation and O-arm for Transoral Transpalatal Odontoidectomy to Treat a Very High Basilar Invagination
Authors: Moorthy Skanda , Raheja Amol , Agrawal Deepak 
Published: December 2016

ABSTRACTFrameless stereotactic neuronavigation system has been in wide use since many years for precise localization of cranial tumors and navigation for spinal instrumentation. We present its usage in the localization of odontoid process in a very high basilar invagination for a transoral transpalatal resection of the same. We discuss the technical aspects of assembly of neuronavigation system, O-arm and Mayfield head frame on Allen spine system to achieve precise and accurate localization of high riding odontoid process through an extremely narrow operative corridor.
Pilocytic Midbrain Astrocytoma Presenting with Fresh Bleed after Twenty-one-years Survival Following First Surgery: A Unique Case of Longest Brainstem Glioma Survival
Authors: Satyarthee Guru Dutta , Sudhan M. D. , Mehta V. S. 
Published: December 2016

ABSTRACTBrainstem glioma usually carries a poor prognosis and prolonged survival is very infrequent. In a detailed Pubmed, Medline search for prolonged survival, authors could got a longest survival only up to seventeen years, reported by Umehara et al, who was subjected to gamma knife therapy and got symptomatic, MRI brain reveled large tumor growth during pregnancy necessitating emergency surgery and histopathological diagnosis was pilocytic astrocytoma. Authors report an interesting case of midbrain glioma diagnosed 21 years back, who underwent gross resection in the year 1993, histopathology was pilocytic astrocytoma, WHO grade I, and received gamma knife surgery for residual subsequently and he presented with sudden onset left sided hemiplegia on the current admission. The cranial MRI imaging revealed an infarct involving right hemi midbrain, contrast MRI brain revealed no residual glioma. To the best knowledge of authors such prolonged survival is not reported with a case of brainstem glioma survived twenty- one years with non residual tumor on the last imaging study represents first case of its kind in the western literature and probably developed hemiplegia due to bleed, highlighting bleed as delayed complication following gamma knife therapy for cranial tumors
Association of Serum Calcium Levels with Infarct Size in Acute Ischemic Stroke: Observations from Northeast India
Authors: Borah Meghna , Dhar Sriparna , Gogoi Dipankar Mall , Ruram Alice Abraham 
Published: December 2016

ABSTRACT
Background: Calcium is known to be major mediator in ischemic neuronal cell death. Recent studies have shown that elevated serum calcium levels at admission in patients with stroke have been associated with less severe clinical deficits and with better outcomes. Aim: The aim of this to determine the correlation between serum calcium (total, corrected, and ionized) and infarct size (IS) in patients with acute ischemic stroke. Materials and Methods: Data were collected from 61 patients presenting with acute ischemic stroke from May 2015 to April 2016 at a tertiary care institute in Northeast India. Only patients aged ≥40 years and diagnosed as having acute ischemic cerebrovascular stroke with clinical examination and confirmed by a computed tomography scan were included in the study. Serum calcium levels (total, albumin corrected, and ionized) were collapsed into quartiles, and these quartile versions were used for calculating correlation. Pearson’s correlation coefficient was used for comparing calcium levels with IS. Results: Total calcium, albumin-corrected calcium, and ionized calcium had a statistically significant negative correlation with IS with r = −0.578, −0.5396, and −0.5335, respectively. Total and ionized calcium showed a significant negative correlation with IS across all four quartiles. Albumin-corrected calcium levels showed a significant negative correlation with IS only across the lowest and highest quartiles. Conclusion: The findings in our study suggest that serum calcium can be used as a prognostic indicator in ischemic stroke as its levels directly correlates with the IS.
Ewing’s Sarcoma of the Cranial Vault
Authors: Narayanan Geetha , Sreelesh K. P. , Somanathan Thara , Soman Lali V. 
Published: December 2016

ABSTRACTPrimary Ewing’s sarcoma (EWS) arising from cranial bones is rare and accounts for only 1%–4% of all EWS. We report the case of a 15-year-old girl with EWS of the frontoparietal region of the skull. She underwent excision following which she received combination chemotherapy with vincristine, doxorubicin, cyclophosphamide alternating with ifosfamide, and VP16 and local radiation of 45 Gy. She is alive in complete remission at 40 months.
Role of Thalamus in Recovery of Traumatic Brain Injury
Authors: Munivenkatappa Ashok , Agrawal Amit 
Published: December 2016

ABSTRACTDegree of recovery after traumatic brain injury is highly variable that lasts for many weeks to months. The evidence of brain structures involved in recovery mechanisms is limited. This review highlights evidence of the brain structure particularly thalamus in neuroplasticity mechanism. Thalamus with its complex global networking has potential role in refining the cortical and other brain structures. Thalamic nuclei activation both naturally or by neurorehabilitation in injured brain can enhance and facilitate the improvement of posttraumatic symptoms. This review provides evidence from literature that thalamus plays a key role in recovery mechanism after injury. The study also emphasize that thalamus should be specifically targeted in neurorehabilitation following brain injury.
Study of Sleep Disorders and Polysomnographic Evaluation among Primary Chronic Daily Headache Patients
Authors: Verma Rajesh , Nagar Kamal Kumar , Garg Ravindra Kumar , Uniyal Ravi , Sharma Praveen Kumar , Pandey Sweta 
Published: December 2016

ABSTRACT
Objective: Studies related to sleep disorders and polysomnography (PSG) among chronic daily headache patients are rare. We studied this and compared chronic migraine (CM) with chronic tension-type headache. Methods: Eighty-three patients were recruited. They were evaluated by semi-structured interview, headache, and sleep diaries along with Epworth Sleepiness Scale score and insomnia symptom score. Overnight PSG was performed and data compared. Results: Chronic tension-type headache was more common than CM, both having female preponderance. Insomnia followed by excessive daytime sleepiness was prevalent sleep disorder. Sleep efficiency and Stage 3 sleep were lower in CM compared to chronic tension-type. ESSS was significantly increased among chronic tension-type patients. No significant correlation was found among PSG parameters in patients with or without sleep disorders. Conclusion: Insomnia being most common sleep disorder among chronic headache population. Chronic tension-type headache had slightly better slow-wave sleep than CM and significantly increased daytime sleepiness.
Pattern Reversal Visual Evoked Potential and Cognitive Functions in Subclinical Hypothyroid Subjects
Authors: Jaiswal Pooja , Saxena Yogesh , Gupta Rani , Kaushik Rajeev Mohan 
Published: December 2016

ABSTRACT
Background: Central nervous system (CNS) involvement is insidious and may occur early in subclinical hypothyroid (SCH) state which can be picked up by electrophysiological study. This study aims to record visual evoked potential (VEP), event-related latency and cognitive functions, and find their association with the levels of serum thyroid-stimulating hormone (TSH) in patients with SCH. Materials and Methods: In this cross-sectional study, 36 adult SCH patients and an equal number of age- and sex-matched euthyroid controls were included. Pattern reversal VEP, visual reaction time (RT), digit spanning test, and AB clock test (ABCT) were done in both SCH cases and euthyroid controls. The observed values were analyzed for comparison of mean values between the groups and correlation of recorded variables with the levels of serum TSH. Results: SCH cases showed a higher P100 (VEP) latency in both the right (103.2 ± 12.3 vs. 102.7 ± 6.8 ms) and left eye (101.1 ± 9.1 vs. 96.2 ± 10.7 ms) as compared to controls, but the difference was statistically insignificant. A significant delay in RT was observed on visible spectra of light in SCH cases (P < 0.001). Digit spanning score (forward and backward) in SCH cases was significantly lower than controls (P < 0.001), and a lower standardized score (<124 or <95th percentile) was significantly associated with SCH state (P = 0.027). No significant difference was observed in visuospatial domain by ABCT between both the groups although the median score was lower in SCH cases. Only digit spanning score showed a significant negative correlation with TSH levels (r = −0.4; P = 0.001). Conclusion: Decline in working memory and RT to visual stimuli is an evidence of the involvement of CNS in SCH. Prolonged latency in VEP may depend on the duration of SCH.
Variação na concordância verbal de “nós” no presente e pretérito perfeito em verbos regulares de 1a e 2a conjugação: produtiva no sudeste paranaense?
Authors: Pereira Ivelã , Coelho Izete Lehmkuhl , Loregian-Penkal Loremi 
Published: December 2016

O tema deste artigo é a variação morfêmica na P4 (nós) em verbos regulares de 1a e 2a conjugação, objetivando a descrição e análise das formas canônicas e não canônicas – como -a-mo(s) versus -e-mo(s), além de -e-mo(s) versus -i-mo(s) – na mesorregião sudeste do Paraná. Para tanto, fundamentou-se em Labov (2008 [1972]; 1994) e Weinreich, Labov e Herzog (2006 [1968]), Amaral ([1920]), Câmara Junior ([1970]), Castilho (1992) e outros. A pesquisa utilizou-se de metodologia qualitativa, analisando dados de fala e de escrita nas cidades Irati e Mallet, do sudeste paranaense. A partir dos resultados, con rmou-se a hipótese de produtividade da variante não canônica nessa região.
Trunnion Corrosion in Metal-on-Polyethylene Total Hip Arthroplasty: A Case Series
Authors: Raju Sivashanmugam , Chinnakkannu Karthikeyan , Puttaswamy Mohan K. , Phillips Matthew J. 
Published: December 2016

Introduction:
Modular total hip arthroplasty implants can help the operating surgeon reproduce the optimum limb length and offset; however, the modularity can lead to fretting and corrosion with associated metal-related problems. Although metal-on-metal bearings are often reported to have problems, recent case reports suggest that the problems can occur with any articulation, usually as a result of problems at the head/neck junction.

Methods:
We retrospectively reviewed three cases of a specific implant combination with nontraumatic trunnion failure, with two cases presenting as acute complete dissociation of the femoral head from the neck.

Results:
All three cases had failure of the Accolade TMZF plus stem and trunnion (Stryker) that progressed rapidly from the onset of symptoms. The most likely contributing factors to failure were large femoral head size, high horizontal offset, a low angled neck, and a β titanium alloy taper with a cobalt-chromium head.

Conclusion:
We recommend regular follow-up of all patients with Accolade TMZF stems, and patients should be advised to seek immediate medical attention if they have any new mechanical symptoms in a metal-on-polyethylene total hip arthroplasty. Providers should specifically look for any alteration of alignment between the femoral head and neck in follow-up radiographs.
Preclinical formulation for the pharmacokinetics and efficacy of GBO-006, a selective polo like kinase 2 (PLK2) inhibitor for the treatment of triple negative breast cancer
Authors: Maddi Srinivas , Akkireddy Ravi , Lenkalapelly Srinivas , Srivastava Pratima , Boruwa Joshodeep , Deb Chandra , Chowdhury Arnab Roy , Jeyaraj Duraiswamy A. , Reddy Ramana , Reddy Premkumar , Maniar Manoj , Bansal Sachin , Gupta Jang B. 
Published: December 2016

<p class="ADMETabstracttext">GBO-006 was shown to be a highly specific and selective PLK2 inhibitor that promoted mitotic arrest in various cancer cell lines, subsequently resulting in their apoptotic death. Intraperitoneal alternate day dosing of GBO-006 using 100 % DMSO as formulation showed significant tumor regression in xenograft models, demonstrating proof of concept of PLK2 inhibition in vivo. These studies necessitated the development of a suitable and GRAS (generally considered as safe) preformulation for pharmacokinetic and efficacy studies. GBO-006 possesses challenging physicochemical and biopharmaceutical properties like poor solubility in aqueous media, low permeability and a crystalline nature. Different methods like cosolvency, complexation and micellar solubilization were employed to improve the solubility of GBO-006. A strategy of co-solvency is used to solubilize the GBO-006 up to 10 mg/mL. A formulation with 20 % DMSO, 40 % PEG 400, 30 % of 100 mM citrate buffer (pH 3.0) and 10 % solutol displayed clear solution without any visual precipitation of the drug even after 2 weeks of storage. GBO-006 showed moderate clearance in rat and high systemic clearance in mouse and dog. It showed poor oral bioavailability across all species. Intraperitoneal dosing of GBO-006 demonstrated the linear exposure. GBO-006 showed significant inhibition of tumor progression. </p><p><span style="font-family: Calibri; font-size: medium;"> </span></p><p><span style="font-family: Calibri; font-size: medium;"> </span></p>
Amplified North Atlantic warming in the late Pliocene by changes in Arctic gateways
Authors: Otto‐Bliesner Bette L. , Jahn Alexandra , Feng Ran , Brady Esther C. , Hu Aixue , Löfverström Marcus 
Published: December 2016

AbstractUnder previous reconstructions of late Pliocene boundary conditions, climate models have failed to reproduce the warm sea surface temperatures reconstructed in the North Atlantic. Using a reconstruction of mid‐Piacenzian paleogeography that has the Bering Strait and Canadian Arctic Archipelago Straits closed, however, improves the simulation of the proxy‐indicated warm sea surface temperatures in the North Atlantic in the Community Climate System Model. We find that the closure of these small Arctic gateways strengthens the Atlantic Meridional Overturning Circulation, by inhibiting freshwater transport from the Pacific to the Arctic Ocean and from the Arctic Ocean to the Labrador Sea, leading to warmer sea surface temperatures in the North Atlantic. This indicates that the state of the Arctic gateways may influence the sensitivity of the North Atlantic climate in complex ways, and better understanding of the state of these Arctic gateways for past time periods is needed.
Raising the Gangdese Mountains in southern Tibet
Authors: Zhu Di‐Cheng , Wang Qing , Cawood Peter A. , Zhao Zhi‐Dan , Mo Xuan‐Xue 
Published: December 2016

AbstractThe surface uplift of mountain belts is in large part controlled by the effects of crustal thickening and mantle dynamic processes (e.g., lithospheric delamination or slab breakoff). Understanding the history and driving mechanism of uplift of the southern Tibetan Plateau requires accurate knowledge on crustal thickening over time. Here we determine spatial and temporal variations in crustal thickness using whole‐rock La/Yb ratios of intermediate intrusive rocks from the Gangdese arc. Our results show that the crust was likely of normal thickness prior to approximately 70 Ma (~37 km) but began to thicken locally at approximately 70–60 Ma. The crust reached (58–50) ± 10 km at 55–45 Ma extending over 400 km along the strike of the arc. This thickening was likely due to magmatic underplating as a consequence of rollback and then breakoff of the subducting Neo‐Tethyan slab. The crust attained a thickness of 68 ± 12 km at approximately 20–10 Ma, as a consequence of underthrusting of India and associated thrust faulting. The Gangdese Mountains in southern Tibet broadly attained an elevation of >4000 m at approximately 55–45 Ma as a result of isostatic surface uplift driven by crustal thickening and slab breakoff and reached their present‐day elevation by 20–10 Ma. Our paleoelevation estimates are consistent not only with the C–O isotope‐based paleoaltimetry but also with the carbonate‐clumped isotope paleothermometer, exemplifying the promise of reconstructing paleoelevation in time and space for ancient orogens through a combination of magmatic composition and Airy isostatic compensation.
Modeling of natural fracture initiation and propagation in basin sedimentation context
Authors: Ouraga Zady , Guy Nicolas , Pouya Amade 
Published: December 2016

AbstractDuring sedimentation, buried rocks are subjected to an increase in vertical stress. This increase leads to a decrease of porosity that is commonly called mechanical compaction. Indeed, the mechanical compaction depending on its rate and on the permeability of the burden rocks can induce significant overpressures. Thus, a competition is initiated between the dissipation of fluid overpressure and sedimentation rate and may result in fracture initiation. The present study deals with the initiation and propagation of natural fracture in sealing formations. A particular emphasis is put on mode I fracture propagation. An analytical solution of the pressure and stresses in a sealing formation is proposed under sedimentation by superposing two problems of poroelasticity. This analytical solution and a damage criterion are used to predict the initiation and propagation of the fracture. The damage parameter affects both the mechanical and hydraulic openings of the fracture, and the flow in the fracture is described by Poseuille's law. The fracture propagation and growth are studied by numerical simulations based on a finite element code dedicated to fractured porous media calledPorofis. Interactions between hydraulic and mechanical processes are also studied, and a sensitivity study is carried out in order to find the most important parameters involved in natural fracturing under sedimentation.
Parameter sensitivity analysis and optimization for a satellite‐based evapotranspiration model across multiple sites using Moderate Resolution Imaging Spectroradiometer and flux data
Authors: Zhang Kun , Ma Jinzhu , Zhu Gaofeng , Ma Ting , Han Tuo , Feng Li Li 
Published: December 2016

AbstractGlobal and regional estimates of daily evapotranspiration are essential to our understanding of the hydrologic cycle and climate change. In this study, we selected the radiation‐based Priestly‐Taylor Jet Propulsion Laboratory (PT‐JPL) model and assessed it at a daily time scale by using 44 flux towers. These towers distributed in a wide range of ecological systems: croplands, deciduous broadleaf forest, evergreen broadleaf forest, evergreen needleleaf forest, grasslands, mixed forests, savannas, and shrublands. A regional land surface evapotranspiration model with a relatively simple structure, the PT‐JPL model largely uses ecophysiologically‐based formulation and parameters to relate potential evapotranspiration to actual evapotranspiration. The results using the original model indicate that the model always overestimates evapotranspiration in arid regions. This likely results from the misrepresentation of water limitation and energy partition in the model. By analyzing physiological processes and determining the sensitive parameters, we identified a series of parameter sets that can increase model performance. The model with optimized parameters showed better performance (R2 = 0.2–0.87; Nash‐Sutcliffe efficiency (NSE) = 0.1–0.87) at each site than the original model (R2 = 0.19–0.87; NSE = −12.14–0.85). The results of the optimization indicated that the parameter β (water control of soil evaporation) was much lower in arid regions than in relatively humid regions. Furthermore, the optimized value of parameter m1 (plant control of canopy transpiration) was mostly between 1 to 1.3, slightly lower than the original value. Also, the optimized parameter Topt correlated well to the actual environmental temperature at each site. We suggest that using optimized parameters with the PT‐JPL model could provide an efficient way to improve the model performance.
Evidence for enhanced convection of North Pacific Intermediate Water to the low‐latitude Pacific under glacial conditions
Authors: Max L. , Rippert N. , Lembke‐Jene L. , Mackensen A. , Nürnberg D. , Tiedemann R. 
Published: December 2016

AbstractWe provide high‐resolution foraminiferal stable carbon isotope (δ13C) records from the subarctic Pacific and Eastern Equatorial Pacific (EEP) to investigate circulation dynamics between the extratropical and tropical North Pacific during the past 60 kyr. We measured the δ13C composition of the epibenthic foraminiferal species Cibicides lobatulus from a shallow sediment core recovered from the western Bering Sea (SO201‐2‐101KL; 58°52.52′N, 170°41.45′E; 630 m water depth) to reconstruct past ventilation changes close to the source region of Glacial North Pacific Intermediate Water (GNPIW). Information regarding glacial changes in the δ13C of subthermocline water masses in the EEP is derived from the deep‐dwelling planktonic foraminifera Globorotaloides hexagonus at ODP Site 1240 (00°01.31′N, 82°27.76′W; 2921 m water depth). Apparent similarities in the long‐term evolution of δ13C between GNPIW, intermediate waters in the eastern tropical North Pacific and subthermocline water masses in the EEP suggest the expansion of relatively 13C‐depleted, nutrient‐enriched, and northern sourced intermediate waters to the equatorial Pacific under glacial conditions. Further, it appears that additional influence of GNPIW to the tropical Pacific is consistent with changes in nutrient distribution and biological productivity in surface waters of the glacial EEP. Our findings highlight potential links between North Pacific mid‐depth circulation changes, nutrient cycling, and biological productivity in the equatorial Pacific under glacial boundary conditions.