bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of CT imaging in addressing resectability issues in differentiated thyroid cancer: imaging-based Mahajan grading system for TI and ETE
Authors: Mahajan Abhishek , Rastogi Shivam , Shukla Shreya , Agarwal Ujjwal , Vaish Richa , Chakrabarty Nivedita , Ashtekar Renuka , Deokar Shonal , Shaikh Atif , Pai Prathamesh , Chaturvedi Pankaj , Ghosh Laskar Sarbani , Smriti Vasundhara , Rane Swapnil U. , Bal Munita , Patil Asawari , Mittal Neha , Noronha Vanita , Patil Vijay , Prabhash Kumar , Dcruz Anil K. 
Published: September 2024

Background and objectiveExtrathyroidal extension (ETE) is the term used to describe the growth of the primary thyroid tumor beyond the thyroid capsule. ETE is a critical prognostic marker for thyroid tumors, necessitating accurate preoperative assessment. This study aims to evaluate the diagnostic performance of computed tomography (CT)-based grading for ETE and tracheal invasion (TI) for preoperative prediction in patients with differentiated papillary thyroid carcinoma (PTC) and compare the diagnostic accuracy with ultrasound (US).Materials and methodsThis retrospective study was approved by our institutional review board. Preoperative US and CT were performed for 83 patients who underwent surgery for PTC between 1 January 2010 and 31 December 2020. The US and CT features of ETE and TI of each case were retrospectively and independently investigated by two radiologists. The diagnostic performances of US and CT, including their specificity, sensitivity, positive predictive value (PPV), and negative predictive value (NPV) for ETE, and their accuracy in predicting ETE and TI were analyzed. As per the grading for ETE on USG and CT, lesions were graded into three grades and Mahajan grading was also devised on CT to predict the TI and graded into four grades.ResultsThe accuracy and specificity of CT are relatively good for identifying tumor infiltration into the adjacent structures and range from 82% to 87% and 95% to 98%, respectively. It, however, has a low sensitivity, between 14.3% and 77.78%, when compared to US, which suggests that in case of any doubt regarding CT evidence of tumor infiltration into surrounding structures, additional clinical examination must be performed. CT showed better sensitivity (78%) and specificity (75%) in detecting TI compared to previous studies. The diagnostic accuracy of CT Mahajan grading was 91.5% with p &lt;0.005 in the prediction of TI.ConclusionPreoperative US should be regarded as a first-line imaging modality for predicting minimal ETE, and CT should be additionally performed for the evaluation of maximal ETE. The specificity and PPV of CT are higher than those of US in detecting overall ETE and TI of PTC. The US- and CT-based grading systems have the potential to optimize preoperative surgical planning.
USP7 regulates growth and maintains the stemness of p53-mutant colorectal cancer cells via stabilizing of mutant p53
Authors: Li Xue , Pan Jie , Zheng Pengcheng 
Published: September 2024

IntroductionTP53 is one of the most frequently mutated genes among all cancers, and TP53 mutants occur more than 40% in colorectal cancers (CRCs). Accumulation of mutant p53 may augment colorectal cancer stem cells (CCSCs) phenotype and enhance colorectal tumorigenesis. Thus, reducing the level of mutant p53 protein is an attractive anticancer strategy.MethodsCSC-enriched cancer cells were obtained by tumor sphere formation assay. The effects of USP7 on the proliferation of cancer cells were determined by MTS and colony formation assays. Wound healing assay was used to test cell migratory abilities. qPCR and western blotting assays were performed to verify the mRNA and protein levels of CSC markers, USP7 and p53. Co-immunoprecipitation assay was used to test the interaction effects between USP7 and p53.ResultsIn this study, we found that USP7 and mutant p53 were dramatically elevated in CSC-enriched colorectal cancer cells and USP7 expression was positively associated with self-renewal and maintenance of CCSCs. USP7 regulated cell growth, stemness and migration of colorectal cancer cells. USP7 depletion significantly reduced proliferation of cancer cells and suppressed the self-renewal of CSC-enriched colorectal cancer cells. Further studies indicated that USP7 knockdown could significantly decrease mutant p53 protein levels both in CRCs and CSC-enriched colorectal cancer cells. Moreover, mutant p53 was stabilized by USP7 and they interacted with each other. Furthermore, USP7 inhibitor P5091 also diminished CCSCs self-renewal and reduced mutant p53 levels.ConclusionTaken together, our findings demonstrated that USP7 involved in the modulation of CCSCs stemness, as well as a critical target for clinical treatment of cancers with different p53 mutations.
Cleft lip and palate transmembrane protein 1-like is a putative regulator of tumorigenesis and sensitization of cervical cancer cells to cisplatin
Authors: Liu Weipeng , Huang Fengdan , Yao Yueting , Liang Yan , Yan Zhiling , Guo Lili , Zhang Xinwen , Shi Li , Yao Yufeng 
Published: September 2024

BackgroundCervical cancer stands as one of the leading causes of cancer-related mortality in women worldwide, yet the precise functions of host genes implicated in its pathogenesis remain elusive. Genome-wide association studies (GWAS) have revealed a significant association between the CLPTM1L locus and cervical cancer risk in European women, and aberrant expression of CLPTM1L has been noted in various malignant tumors. However, the role of CLPTM1L in cervical cancer remains largely unexplored.MethodsThe expression of CLPTM1L in cervical cancer cells and tissues was detected by RT-qPCR. Furthermore, the potential biological functions of CLPTM1L in the context of cervical cancer were explored via RNA sequencing. Cell proliferation rates and the responsiveness of cervical cancer cells to cisplatin were evaluated using the CCK-8 assay, while cell apoptosis was quantified through the utilization of flow cytometry. Nude mouse xenograft models were utilized to explore the impact of CLPTM1L on tumor formation in vivo.ResultsOur findings demonstrated a significant increase in CLPTM1L mRNA expression levels in HeLa and C33A cells, as well as in cervical carcinoma tissues, compared to ECT1/E6E7 cells and adjacent normal tissues. Genes related to CLPTM1L were found to be enriched in the Hedgehog signaling pathway. In vitro and in vivo studies showed that reducing CLPTM1L expression markedly inhibited cell proliferation via downstream candidate genes BOC and LRP2. Furthermore, the downregulation of CLPTM1L was found to enhance cisplatin-induced cell apoptosis and increase the susceptibility of cervical cancer cells to cisplatin through DAP1.ConclusionsCLPTM1L could impact cervical cancer cell proliferation and cisplatin-induced cell apoptosis, as well as cisplatin susceptibility in cervical cancer cells. This investigation has bestowed upon us novel insights into the pathogenesis of cervical cancer, underscoring the potential of CLPTM1L as a promising target for chemotherapeutic sensitization in the management of this malignancy.
Research trends on chemotherapy induced nausea and vomiting: a bibliometric analysis
Authors: Ning Chunhui , Yan Yunzi , Wang Yansong , Li Rui , Liu Wenjie , Qiu Linjie , Sun Lingyun , Yang Yufei 
Published: September 2024

BackgroundCINV is a frequent adverse response to cancer treatment. There is still much to learn about the pathophysiology and initiating event of CINV, which necessitates continued research despite decades of effort. Identifying the current foci of the complex disease and assessing the scientific impact of pertinent study are made more difficult by the abundance of publications on CINV. Therefore, our goals in this article are to evaluate developments in this field, examine patterns in research domains, and gauge the expansion of CINV research production globally.MethodsArticles about CINV published between 2012 and 2022 were found by searching the Web of Science Core Collection of Clarivate Analytics. The number of publications over time was visualized using Microsoft Office Excel 2019. CiteSpace and VOSviewer were utilized to create knowledge maps that analyzed collaborations between nations, organizations, and writers. They also presented the history of CINV research and highlighted its current areas of focus.ResultsIn this study, 846 papers in all were assessed. Most publications (237, 28.01%) came from the United States. University of Toronto was the most productive institution (34, 4.01%). With 25 articles published, or 2.96% of the total, Aapro Matti published the most. The most frequently published journal was found to be Supportive Care (158, 18.68%). “Palonosetron,” “Moderately emetogenic chemotherapy,” “5-HT3 receptor antagonist,” and “Neurokinin 1 receptor antagonists” were considered the hot topics. It can be seen that the research focus is on the drug treatment of chemotherapy-induced nausea and vomiting.ConclusionThrough bibliometric analysis, we were able to gain profound insights into CINV research for the first time. Researchers looking to uncover research frontiers and comprehend important information in this discipline may find the study’s findings useful.
Exploring medication self-management in polypharmacy: a qualitative systematic review of patients and healthcare providers perspectives
Authors: Jin Ran , Liu Caiyan , Chen Jinghao , Cui Mengjiao , Xu Bo , Yuan Ping , Chen Lu 
Published: September 2024

Purpose: Polypharmacy presents many challenges to patient medication self-management. This study aims to explore the self-management processes of medication in polypharmacy from the perspectives of both patients and healthcare providers, which can help identify barriers and facilitators to effective management.Methods: A systematic review of qualitative studies was performed by searching seven databases: PubMed, Web of Science, Cochrane Library, Embase, CINAHL, PsycINFO, and MEDLINE, from their establishment until August 2024. The Critical Appraisal Skills Programme (CASP) tool was employed to evaluate the quality of the studies included. The extracted data were then analysed thematically and integrated into The Taxonomy of Everyday Self-management Strategies (TEDSS) framework.Results: A total of 16 studies were included, involving 403 patients and 119 healthcare providers. Patient management measures were mapped into TEDSS framework, including categories such as medical management, support-oriented domains, and emotional and role management.Conclusion: Enhancing patients’ proactive health awareness, improving medication literacy, balancing lifestyle adjustments with medication therapy, dynamically reviewing and optimizing medications, strengthening patients’ social support networks, and helping patients integrate medication management into their daily life are the key elements that can effectively assist patients in self-managing their medications. Future interventions to improve patient medication self-management ability should be designed for these issues.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024524742.
Optimizing daylily (Hemerocallis citrina Baroni) cultivation: integrating physiological modeling and planting patterns for enhanced yield and resource efficiency
Authors: Li Weijia , Zhang Kun , Liu Jianxia , Wu Juan , Zhang Yue , Henke Michael 
Published: September 2024

IntroductionOptimizing the dynamics of daylily (Hemerocallis citrina Baroni) growth under various planting patterns is critical for enhancing production efficiency. This study presents a comprehensive model to simulate daylily growth and optimize planting patterns to maximize bud yield while minimizing land resource utilization.MethodsThe model incorporates source-sink relationship specific to daylilies into physiological process modeling, considering environmental factors such as micro-light and temperature climate, and CO2 concentration. Spatial factors, including planting pattern, row spacing, plant spacing, and plant density were examined for their impact on light interception, photosynthesis, and resource efficiency. Employing partial least square path modeling (PLS-PM), we analyzed the interrelations and causal relationships between planting configurations and physiological traits of daylily canopy leaves and buds. Through in situ simulations of 36 planting scenarios, we identified an optimal configuration (Scenario ID5) with a density of 83,000 plants·ha−1, row spacing of 0.8 m, and equidistant planting with a plant spacing of 0.15 m.Results and discussionOur research findings indicate that increased Wide+Narrow row spacing can enhance yield to a certain extent. Although planting patterns influence daylily yield, their overall impact is relatively minor, and there is no clear pattern regarding the impact of plant spacing on individual plant yield. This modeling approach provides valuable insights into daylily plant growth dynamics and planting patterns optimization, offering practical guidance for both farmers and policymakers to enhance daylily productivity while minimizing land use.
Adaptations to family-based treatment for Medicaid-insured adolescents with anorexia nervosa
Authors: Borges Renee , Crest Peyton , Landsverk John , Accurso Erin C. 
Published: September 2024

BackgroundFamily-based treatment (FBT) is the leading intervention for adolescents with anorexia nervosa (AN); however, it is under researched in socioeconomically disadvantaged and racially diverse youth.MethodsSemi-structured interviews were completed with ten FBT clinicians who practice in publicly-funded settings. Interview questions were focused on implementation challenges, overall acceptability and appropriateness of FBT, and naturally-occurring treatment adaptations.ResultsContent analysis revealed common themes relating to the implementation of FBT in publicly-funded, community-based settings: acceptability and appropriateness, complexity and learnability, perceived core components of FBT, cultural adaptations, socioeconomic factors, logistical considerations, organizational and systemic barriers, training acceptability, participant’s self-efficacy, and telehealth accommodations.ConclusionThe discussed themes offer insights into the implementation of FBT for settings with limited resources, aligning with prior research on clinical adaptations for multicultural patients. Recognizing these themes can guide clinical adjustments and refine the adapted treatment model in real-world settings for patients facing systemic barriers.
How to improve emotional regulation in breast cancer survivors? A psychological intervention
Authors: Sebri Valeria , Policardo Giulia Rosa , Pravettoni Gabriella 
Published: September 2024

ObjectivePsychological interventions are pivotal in enhancing the Quality of Life for breast cancer survivors, with a primary focus on addressing affective and cognitive challenges through group discussions among those diagnosed with the disease. While the influence of Body Image on overall well-being is well-documented, research on interventions specifically designed to address Body Image concerns in this demographic remains scarce. The present study aimed to fill this gap by evaluating the outcomes of a psychological intervention focused on fostering a positive Body Image among 25 breast cancer survivors.MethodParticipants were divided into an experimental group, which received the intervention (n = 13), and a control group that did not receive any psychological support (n = 12).ResultsOur findings highlight significant disparities in emotional regulation strategies, specifically cognitive reappraisal and expressive suppression, with the intervention group reporting enhanced emotional regulation. Contrary to initial hypotheses, the analysis unveiled statistically significant differences in both negative (social physique anxiety) and positive (functionality appreciation) body image dimensions, indicating elevated levels of social physique anxiety and reduced functionality appreciation among intervention participants.ConclusionThe total results may suggest that the intervention, while effective in enhancing emotional regulation, heightened awareness of body image issues, leading to increased social physique anxiety and diminished functionality appreciation. The paper further discusses practical implications arising from these insights.
Psychological capital and music performance anxiety: the mediating role of self-esteem and flow experience
Authors: Jiang Xin , Tong Yanli 
Published: September 2024

BackgroundThis study aimed to explore the correlation between psychological capital and music performance anxiety among Chinese college students majoring in music. Additionally, the study evaluated the chain mediating effects of self-esteem and flow experience.MethodsThree hundred twenty-nine college students pursuing a music major from institutions in Eastern China participated in the study. They were asked to complete the Psychological Capital, Self-Esteem, Flow Experience, and Music Performance Anxiety Scales. Descriptive statistics and correlation analysis were performed, and sophisticated mediation models were created.ResultsThe results suggest that self-esteem and flow experience play a role in connecting psychological capital and music performance anxiety. Moreover, the ultimate model elucidates significant connections linking psychological capital to self-esteem and flow experience in music performance anxiety.ConclusionThis study offers useful insights for future interventions aimed at mitigating music performance anxiety through the cultivation of students’ psychological capital, self-esteem, and flow experiences.
Impact of exercise type, duration, and intensity on depressive symptoms in older adults: a systematic review and meta-analysis
Authors: Li Xinglu , He Shaokai , Liu Tao , Zhang Xinxin , Zhu Wenfei , Wang Chao , Sun Yuliang 
Published: September 2024

ObjectiveThis systematic review and meta-analysis assessed the effects of three types of physical exercise (resistance exercise, aerobic exercise, and group exercise), different exercise intervention times (3 months, 6 months), and different exercise intensities (low, moderate, and high) on the improvement of depressive symptoms in older adults aged ≥60 years, as well as to explore the impact of the sustainability of these physical exercise intervention programs on depressive symptoms in older adults.MethodsThe randomized controlled trials (RCTs) on the effect of physical exercise on depressive symptoms in older adults were retrieved from Cochrane Library, Web of Science, PubMed, and Embase Data. The retrieval time limit is from establishing the database to January 7, 2024. We conducted a meta-analysis using a 95% confidence interval (95% CI) and the standardized mean differences (SMD). The I2 statistic was used to assess the heterogeneity of the outcomes of the studies. When I2 &lt; 50%, we used the fixed-effects model, and when I2 &gt; 50%, we used the random-effects model. Subgroup and sensitivity analyses investigated heterogeneity origins.ResultsThere are 15 articles reported 20 studies, with a total of 1,346 patients, including 689 in the control group and 657 in the experimental group. The findings demonstrated a notable improvement in depression symptoms among older persons as an immediate result of engaging in physical exercise [SMD = −0.82, 95% CI (−1.19, −0.45)]. The subgroup analysis showed that moderate-intensity physical exercise [SMD = −0.25, 95% CI (−0.47, −0.03)], high-intensity physical exercise [SMD = −0.94, 95% CI (−1.37, −0.51)], resistance exercise [SMD = −0.70, 95% CI (−1.20, −0.20)], and group exercise [SMD = −0.97, 95% CI (−1.89, −0.05)], and the exercise intervention time was 3 months [SMD = −0.81, 95% CI (−1.38, −0.23)] or 6 months [SMD = −0.93, 95% CI (−1.46, −0.41)] were more effective in improving depressive symptoms in older adults.ConclusionThe sustainable resistance and group exercise have a better effect on improving depressive symptoms in older adults. Appropriate exercise intervention time can also ensure the sustainable improvement effect of exercise.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/record_email.php, identifier CRD42023405525.
Effects of different exercise interventions on executive function in children with autism spectrum disorder: a network meta-analysis
Authors: Hou Yaoqi , Wang Yan , Deng Jiaqi , Song Xiangqin 
Published: September 2024

BackgroundA large body of research has identified the positive effects of physical activity on children with autism spectrum disorders (ASD). However, the specific benefits of different types of sports on executive functioning in children with ASD remain unclear. The aim of this study was to further analyze the effects of different sports on executive functioning in children with ASD using reticulated meta-analysis and to establish their effectiveness ranking.MethodsThis study conducted a comprehensive online search in Web of Science, PubMed, Cochrane, Embase, and CNKI databases. It included randomized controlled trials and quasi-experimental studies, and synthesized the data using a Bayesian framework.ResultsSeveral relevant studies were included. The results showed that physical activity significantly improved all three dimensions of executive functioning (inhibitory control, cognitive flexibility, and working memory) in children with ASD. The improvement in cognitive flexibility and inhibitory control both reached a medium effect size. However, the improvement in inhibitory control was better than that in cognitive flexibility, while the improvement in working memory did not reach the level of a medium effect. Mini Basketball was effective in improving inhibitory control and cognitive flexibility, but not working memory. Ping Pong was more effective in cognitive flexibility and working memory, but weaker in inhibitory control. Fixed Bicycle was less effective in all three dimensions. Among other interventions, Learning Bicycles, Animal-assisted therapy, and Exergaming performed better in cognitive flexibility. SPARK, Neiyang Gong, and Martial Arts were also effective in improving inhibitory control. However, SPARK and Fixed Bicycle were not significant in improving working memory.ConclusionPhysical activity as an intervention can significantly improve the executive function of children with ASD. The intervention effects of different sports on different dimensions of executive function vary. Mini Basketball was outstanding in improving inhibitory control and cognitive flexibility. Ping Pong was effective in improving cognitive flexibility and working memory. Fixed Bicycle was not effective in any dimension.
The effect of the Smart Health Continuous Feedback For Elderly Exercise (SHe CoFFEE) program on mobility: a randomized controlled pilot study
Authors: Yi Jungeun , Lee Sunhee , Lee Seon Heui 
Published: September 2024

ObjectivesThis study determined the effectiveness of a comprehensive home-based online exercise program called “Smart Health Continuous Feedback for elderly exercise (SHe CoFFEE)” on mobility.MethodsSixty community-dwelling seniors were randomized in a 1:1 ratio to intervention or control group. Intervention was an 8-week “SHe CoFFEE” program, featuring continuous feedback, self-monitoring, and fall prevention exercises. The primary outcome was mobility, measured at 8 weeks with the Timed Up and Go (TUG) test. Secondary outcomes included TUG at 4 weeks, 10 m walking test, 30-s chair stand test, falls efficacy scale, activity-specific balance confidence, and Euro Quality of Life 5 Dimensions 5 Levels.ResultsAt 8 weeks, the intervention group showed improved TUG scores compared with the control group (MD = −1.87, 95% CI, −2.60 to −1.14; ηp2 = 0.326) in the adjusted intention-to-treat analysis. The per-protocol analysis data showed similar results. All secondary outcomes apart from quality of life improved with intervention to a greater degree than in control.ConclusionSmart healthcare and self-managed exercise programs may be viable for community-based health promotion and fall prevention in older adults unfamiliar with online technology.