bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of novel pQTL‐SNPs associated with lung adenocarcinoma risk: A multi‐stage study
Authors: Wu Yutong , Xu Huiwen , Mao Liping , Zhao Rongrong , Chu Junfeng , Huang Lili , Zhang Wendi , Liu Yiran , Chen Qiong , Tao Xiaobo , Li Siqi , Zhou Shenxuan , Ning Anhui , Li Zhenyu , Tian Tian , Zhang Lei , Cui Jiahua , Tian Guangyu , Chu Minjie 
Published: September 2024

AbstractBackground and ObjectiveTo explore the association between protein quantitative trait loci (pQTL‐SNPs) and the risk of LUAD.Methods“Blood +” high depth blood proteomics analysis was performed on plasma from female LUAD patients and female healthy controls, and combined with proteomics data from tumors and adjacent non‐tumor tissues of female LUAD patients to screen proteins uniformly expressed in plasma and tissues. pQTL‐SNPs were then screened through multiple databases and subjected to multilevel screening. The associations between selected pQTL‐SNPs and LUAD risk were evaluated by Female Lung Cancer Consortium in Asia GWAS (FLCCA GWAS). Enzyme linked immunosorbent assay (ELISA) is used to determine the levels of candidate protein.ResultsA total of 7 pQTL‐SNPs were significantly associated with altered LUAD risk (p < 0.05). Meanwhile, the expression of their corresponding target proteins were all decreased in both plasma and tumor tissues of LUAD cases, which may play a role of tumor suppressor proteins. After mutation of 3 pQTL‐SNPs (rs7683000, rs73224660, and rs2776937), the expression of corresponding target proteins BST1 and NRP1 decreased, and as potential tumor suppressor proteins, which may promote tumorigenesis and further increasing the risk of developing LUAD (OR >1, p < 0.05); while after mutation the other pQTL‐SNP rs62069916, the corresponding target protein APOH expression was increased, while as a potential tumor suppressor protein, which may inhibit tumorigenesis and further reduced the risk of developing LUAD (OR <1, p < 0.05). In addition, the expression of NRP1 and APOH were significant decreased in LUAD cell lines and validated in plasma of LUAD patients.ConclusionA total of 4 pQTL‐SNPs (rs7683000, rs73224660, rs2776937, and rs62069916) may associate with altered LUAD risk by regulating the expression of target proteins (BST1, NRP1, and APOH) after mutation.
Decoding millennials and generation Z consumers' brand behaviors in the Metaverse: The relationships among avatar identification, self‐presence, and psychological dynamics
Authors: Kim Mikyoung , Oh Hyun Jung , Choi Ji Hye , Jung Yumi 
Published: September 2024

AbstractThis study investigated the impact of consumer avatar identification on purchase intentions in the Metaverse, examining the roles of self‐presence, emotional closeness, and perceived appropriateness of brand strategies. A total of 312 individuals aged 18–42 years old (comprising millennials and Generation Z) participated in an online survey. The findings indicated that wishful identification significantly fosters self‐presence and emotional closeness compared to similarity identification. Moreover, the heightened emotional closeness to avatars positively influences the perceived appropriateness of brand strategies, subsequently influencing purchase intentions. The study reinforced the importance of understanding consumer avatar relationships in virtual environments for effective brand engagement, suggesting that wishful identification might be more influential in shaping brand perceptions and consumer behaviors in the Metaverse. This study contributes to the existing literature on consumer behavior by investigating the dynamics of consumer behavior of the Metaverse, where consumers' brand experiences are predominantly mediated through avatars.
Comparative long‐term efficacy and safety of two paclitaxel‐coated balloons with different coating strategies for the treatment of drug‐eluting coronary stent restenosis
Authors: Koch Tobias , Lenz Tobias , Rheude Tobias , Cassese Salvatore , Xhepa Erion , Joner Michael , Mehilli Julinda , Schunkert Heribert , Kastrati Adnan , Kufner Sebastian 
Published: September 2024

AbstractBackgroundWe previously showed non‐inferiority of a low‐dose paclitaxel‐coated balloon (PCB) with citrate excipient (Agent PCB) as compared to normal‐dose iopromide excipient (SeQuent Please PCB) in terms of angiographic and clinical endpoints at 12 months. The long‐term clinical efficacy and safety of Agent PCB is not defined.Methods262 patients (323 DES‐ISR lesions) were enrolled in this study and treated with either Agent PCB (125 patients, 151 lesions) in the ISAR‐DESIRE 3a trial or with SeQuent Please PCB (137 patients, 172 lesions) in the setting of the randomized ISAR‐DESIRE 3 trial with similar in‐ and exclusion criteria serving as historical control arm. The follow‐up period was extended to 7 years. The efficacy and safety endpoints of this analysis were target‐lesion revascularization (TLR), death, myocardial infarction (MI) and target lesion thrombosis (TLT) at 7 years.ResultsAt 7 years, 206 patients (78.6%) were alive. The risks of TLR (hazard ratio [HR]: 1.29, 95% confidence interval [CI]: 0.87–1.90; p = 0.205), death (HR: 1.38, 95% CI: 0.82‐2.35; p = 0.227), MI (HR: 1.10, 95% CI: 0.39–3.15; p = 0.852) and TLT (HR: 2.18, 95% CI: 0.20–24.10; p = 0.523) were comparable between Agent PCB and SeQuent PCB. Multivariate analysis showed comparable risks of TLR, death and MI between both PCB devices.ConclusionsIn patients treated for DES‐ISR by angioplasty with Agent PCB and SeQuent Please PCB, there was no statistically significant difference in TLR at 7 years. Randomized trials with standardized lesion preparation and long‐term follow‐up are warranted to further evaluate comparative efficacy of both devices. (ClinicalTrials. gov Identifier: NCT02367495).
Complex Biophysical and Computational Analyses of G‐Quadruplex Ligands: The Porphyrin Stacks Back
Authors: Satta Giuseppe , Trajkovski Marko , Cantara Alessio , Mura Monica , Meloni Claudia , Olla Giulia , Dobrovolná Michaela , Pisano Luisa , Gaspa Silvia , Salis Andrea , De Luca Lidia , Mocci Francesca , Brazda Vaclav , Plavec Janez , Carraro Massimo 
Published: September 2024

AbstractG‐quadruplexes (G4 s), as non‐canonical DNA structures, attract a great deal of research interest in the molecular biology as well as in the material science fields. The use of small molecules as ligands for G‐quadruplexes has emerged as a tool to regulate gene expression and telomeres maintenance. Meso‐tetrakis‐(N‐methyl‐4‐pyridyl) porphyrin (TMPyP4) was shown as one of the first ligands for G‐quadruplexes and it is still widely used. We report an investigation comprising molecular docking and dynamics, synthesis and multiple spectroscopic and spectrometric determinations on simple cationic porphyrins and their interaction with different DNA sequences. This study enabled the synthesis of tetracationic porphyrin derivatives that exhibited binding and stabilizing capacity against G‐quadruplex structures; the detailed characterization has shown that the presence of amide groups at the periphery improves selectivity for parallel G4 s binding over other structures. Taking into account the ease of synthesis, 5,10,15,20‐tetrakis‐(1‐acetamido‐4‐pyridyl) porphyrin bromide could be considered a better alternative to TMPyP4 in studies involving G4 binding.
An Imine‐Functionalized Silicone‐Based Epoxy Coating with Stable Adhesion and Controllable Degradation for Enhanced Marine Antifouling and Anticorrosion Properties
Authors: Gao Duanhui , Liu Hongyi , Zheng Yanling , Shi Zhekun , Hu Jiankun , Meng Fandong , Zhan Xiaoli , Liu Quan , Zhang Qinghua 
Published: September 2024

AbstractBiofouling and corrosion of submerged equipment caused by marine organisms severely restrict the rapid development of the marine industry. Traditional antifouling or anticorrosion coatings typically serve a sole purpose and exhibit limited degradability upon failure, rendering them inadequate for current demands. Herein, a novel imine‐functionalized command‐degradable bio‐based epoxy coating (SAHPEP‐DDM) with enhanced integrated antifouling and anticorrosion performances was synthesized utilizing 1,3‐bis (3‐aminopropyl)‐1,1,3,3‐tetramethyldisiloxane and syringaldehyde. Compared with commercial epoxy resins (E51‐DDM) and polydimethylsiloxanes (PDMS), the SAHPEP‐DDM coating exhibits superior antifouling and anticorrosion properties due to the existence of –C=N‐ and Si−O−Si chain segments in the cross‐linking network. The coating achieves resistance rates of 99.59 % and 99.20 % against E. coli and S. aureus, respectively, and shows promising resistance against algae and proteins, as well as excellent corrosion resistance in artificial seawater (with |Z|0.01 Hz and arc radius of about 1011 Ω and exceeding 1010 Ω respectively). The coating also exhibits excellent chemical resistance in organic solvents as well as neutral and alkaline environments. Moreover, its controlled degradation after coating failure can be achieved in acid aqueous solutions through temperature and acidity adjustments, facilitated by the presence of –C=N‐. This work presents a novel degradable coating successfully coupled the dual functions of antifouling and anticorrosion coatings, avoiding the employment of intermediate coat, indicating vast potential for application in various marine engineering fields.
Gold‐Catalyzed Synthesis of 5H‐Benzo[b]indeno[2,1‐d]silines by Insertion of Vinyl Carbocations into the Si−H Bond
Authors: Sekine Kohei , Fuji Kazuto , Kawashima Kyohei , Mori Toshifumi , Kuninobu Yoichiro 
Published: September 2024

AbstractWe have developed a gold‐catalyzed cascade reaction of aryldiynes bearing a hydrosilyl group to afford a variety of unexplored 5H‐benzo[b]indeno[2,1‐d]silines. The reaction system is applicable to the synthesis of bidirectionally π‐extended silacycles from tetra(alkynyl)aryl compounds. Computational studies suggest that 5H‐benzo[b]indeno[2,1‐d]silines are formed via the insertion of a vinyl carbocation intermediate into the Si−H bond.
Intelligent design of nerve guidance conduits: An artificial intelligence‐driven fluid structure interaction study on modelling and optimization of nerve growth
Authors: Hassani Faridoddin , Golshani Ali , Mehrabi Raman , Kouhkord Afshin , Guilani Mojtaba , Sharbatdar Mahkame 
Published: September 2024

AbstractNerve guidance conduits (NGCs) have been shown to be effective in promoting nerve regeneration in a variety of clinical applications, including nerve defects resulting from a trauma or surgery. By providing a conducive environment for nerve growth, NGCs can help to restore function in nerve‐damaged patients. Challenges include limited repair length, difficulty replicating natural nerve, and rapid substance degradation affecting neurotrophic factor delivery. Considering these issues with mass transfer and fluid structure interaction (FSI) emphasizes the need for enhancing nerve regeneration efficiency. To facilitate nerve growth and deliver appropriate amount of growth factors, these conduits need to be designed with specific topological, mechanical, and biological properties. Additionally, considerations must be given to functional mass transfer FSI design. An intelligent NGC design is proposed as an evaluation‐optimization and AI‐based method. It is found that design parameters significantly impact the physical properties being optimized, including hydraulic pressure, porosity, diffusivity, water absorption, and maximum stress. The mathematical surrogate model obtained from data‐based modelling is used for artificial intelligence (AI) optimization algorithms, differential evolution (DE), and non‐dominated sorting genetic algorithm II (NSGA‐II). It is revealed that both DE and NSGA algorithms generate nearly identical solutions, ensuring the robustness of ML optimization. Our results show that NGC with the thickness of 750 μm results in more than 170% augmentation of porosity. Moreover, at a constant ovality, increasing the channel thickness results in more than 39.2% augmentation of the maximum stress. The accurate forecasting of physical characteristics on NGC regarding nerve growth factors enables a hopeful outlook for the future clinical treatment of nerve injuries and advanced tissue engineering.
Reduction of Tertiary Carbon Radicals via Asymmetric Hydrogen Atom Transfer (AHAT)†
Authors: Han Xue , He Chuan 
Published: September 2024

Comprehensive SummaryIn the past two decades, the development of asymmetric radical reactions has achieved tremendous progress, which has emerged as a powerful tool for the synthesis of chiral molecules in synthetic chemistry. Among the diverse array of radical processes, the transfer of hydrogen atoms to tertiary carbon radicals offers the potential for constructing chiral tertiary carbon centers in a stereoselective fashion. Notwithstanding the challenges associated with the reactive and evanescent nature of radical species, the use of chiral reagents or mediators has enabled the stereocontrol of the asymmetric hydrogen atom transfer (AHAT), which provides novel avenues for advancing the field of asymmetric synthesis.
Key Scientists
Effect of mowing timing and clipping collection practices on azoxystrobin distribution, persistence, and efficacy
Authors: Freund Daniel R. , Kerns James P. , Butler E. Lee , Ahmed Khalied A. , Gannon Travis W. 
Published: September 2024

AbstractPrevious research suggests mowing practices following azoxystrobin application alter pest control and residue fate. Azoxystrobin, an acropetal penetrant quinone outside inhibitor fungicide, is commonly applied in turfgrass and other agricultural settings, protecting desired plants from fungal pathogens by inhibiting fungal growth. Field research was initiated in Raleigh, NC, and repeated in time to assess the effect of post‐application mowing timing and clipping collection practices on azoxystrobin residue persistence in tall fescue (Schedonorus arundinaceus Schreb.). At trial initiation, azoxystrobin was applied at the maximum single application rate (0.61 kg ai ha−1) to tall fescue plots. To determine the effect of initial mowing timing, plots were mowed (9.5 cm) at 0, 1, 2, 3, 7, or 14 days after application (DAA). To determine the effect of clipping removal, plots were mowed at 3, 10, and 17 DAA and clippings were either returned to the canopy or bagged and removed. Concurrently, soil cores (92 cm2) were collected at 3, 7, 14, and 21 DAA and then segmented into remaining aboveground vegetation and soil (0.0‐ to 2.5‐cm depth) for residue analyses. Mowing timing affected azoxystrobin residue in the vegetation and in soil. When clippings were returned to the canopy, 5% more azoxystrobin was detected in the vegetation at 7 and 14 DAA. At 3 and 7 DAA, in the soil, returning clippings resulted in >3% more of the applied azoxystrobin compared to removing clippings. Data from this research may allow for extended fungicide intervals for brown patch suppression and demonstrate the importance of returning clipping to turf systems to retain azoxystrobin residues.
The effect of corporate social responsibility on customer engagement and citizenship behavior
Authors: Mubushar Muhammad , Cerchione Roberto , Rasool Shahid , Centobelli Piera , Morelli Mariarosaria 
Published: September 2024

AbstractDue to the hybrid‐competitive market and the economic crisis, consumers are more ethically concerned about companies failing to adhere to environmental and human rights standards. Thus, companies have implemented corporate social responsibility (CSR) initiatives to improve their ethical performance and establish the groundwork for sustainable growth and competitive advantage. Relationship marketing orientation (RMO) contributes to strengthen customers relationships and value co‐creation. Drawing from the stakeholder theory, this study aims to examine how CSR initiatives, that is, customer‐oriented and employee‐oriented, affect customer participation behavior (CPB) and customer citizenship behavior (CCB) in the banking sector. The main findings highlight a significant correlation between the CSR initiatives and customer value co‐creation behavior. Finally, by triangulating CSR, RMO, and value co‐creation, this study aims to provide more insights on RMO and CSR strategies for academicians and practitioners.
Sampling fish gut microbiota ‐ A genome‐resolved metagenomic approach
Authors: Thormar Eiríkur A. , Hansen Søren B. , Jørgensen Louise von Gersdorff , Limborg Morten T. 
Published: September 2024

AbstractDespite a surge in microbiota‐focused studies in teleosts, few have reported functional data on whole metagenomes as it has proven difficult to extract high biomass microbial DNA from fish intestinal samples. The zebrafish is a promising model organism in functional microbiota research, yet studies on the functional landscape of the zebrafish gut microbiota through shotgun based metagenomics remain scarce. Thus, a consensus on an appropriate sampling method accurately representing the zebrafish gut microbiota, or any fish species is lacking. Addressing this, we systematically tested four methods of sampling the zebrafish gut microbiota: collection of faeces from the tank, the whole gut, intestinal content, and the application of ventral pressure to facilitate extrusion of gut material. Additionally, we included water samples as an environmental control to address the potential influence of the environmental microbiota on each sample type. To compare these sampling methods, we employed a combination of genome‐resolved metagenomics and 16S metabarcoding techniques. We observed differences among sample types on all levels including sampling, bioinformatic processing, metagenome co‐assemblies, generation of metagenome‐assembled genomes (MAGs), functional potential, MAG coverage, and population level microdiversity. Comparison to the environmental control highlighted the potential impact of the environmental contamination on data interpretation. While all sample types tested are informative about the zebrafish gut microbiota, the results show that optimal sample type for studying fish microbiomes depends on the specific objectives of the study, and here we provide a guide on what factors to consider for designing functional metagenome‐based studies on teleost microbiomes.
Isomerism in Molecular Metal Carbonyl Clusters
Authors: Cesari Cristiana , Femoni Cristina , Forti Francesca , Iapalucci Maria Carmela , Scorzoni Giorgia , Zacchini Stefano 
Published: September 2024

AbstractThe present microreview focuses on different typologies of isomerism documented along the years for metal carbonyl clusters (MCCs), and outlines their analogies to other classes of ligand‐protected molecular clusters and nanoclusters. Isomerism in molecular MCCs is discussed within two main categories, that is, surface isomerism and core isomerism. The first Section presents some representative examples of surface isomerism involving inorganic (carbonyls and hydrides) and organic ligands, as well as isomerism due to ML fragments decorating the cluster surface. The second Section focuses on three major categories of core isomerism, that is: (1) isomers that mainly differ on M–M distances; (2) isomers displaying different structures of the metal kernels; (3) isomers possessing almost identical metal kernels and ligand shells, but differing for the positions of different types of metal atoms within the metal kernel. The third Section briefly discusses two related and very rare cases of isomerism, that is, polymerisation and coordination isomerism. General conclusions are outlined in the final Section.
Iridium‐Pyrazolato Complex Catalyzed Dehydrogenative Alkylation of Ketones and Arylacetonitriles with Primary Alcohols
Authors: Panda Surajit , Maharana Suraj Kumar , Saha Ratnakar , Bagh Bidraha 
Published: September 2024

AbstractHerein, we report the use of an air‐stable iridium pyrazolato complex as an effective catalyst for the α‐alkylation of ketones and arylacetonitriles with primary alcohols, employing borrowing hydrogen strategy. The alkylation reactions were efficiently conducted at 120 °C in toluene utilizing a very low catalyst loading (0.1 mol %). A broad range of ketones and arylacetonitriles, in combination with various aromatic and aliphatic primary alcohols, were successfully transformed into the corresponding α‐alkylated products. Additionally, quinoline derivatives were synthesized from 2‐aminobenzylalcohol and ketones using dehydrogenative coupling strategy. A mechanistic investigation unveiled that the key step involved alcohol activation via metal‐ligand cooperation.
Impaired somatosensory habituation in older adults with chronic pain during an affective oddball task
Authors: Dorado Alejandro , Sitges Carolina , van der Meulen Marian , González‐Roldán Ana M. 
Published: September 2024

AbstractBackgroundChronic pain is one of the most common health conditions among older adults, triggering various disruptions in information processing across attentional, emotional, and somatosensory domains. However, there is insufficient information about how these aspects interact and their potential contribution to the vulnerability of older adults to chronic pain. This study aimed to investigate potential alterations induced by chronic pain during aging in attentional aspects of tactile stimulation and to observe the influence of affective context.MethodTwenty‐six older adults with chronic pain (70.00 ± 5.07 years; 11 males), 28 pain‐free older adults (69.57 ± 3.96 years; 13 males) and 27 healthy younger adults (21.48 ± 1.80 years; 14 males) participated in the study. We compared the somatosensory evoked potentials elicited by frequent and deviant stimulation (probability 14%) applied when participants were viewing blocks of pleasant, unpleasant, and neutral images from the International Affective Picture System.ResultsDuring frequent stimulation, older adults with chronic pain showed higher P50 and N100 amplitudes compared to pain‐free older adults and younger individuals. Furthermore, the older group with pain exhibited higher P300 amplitude during emotional contexts compared to neutral scenarios. During deviant stimulation, older adults with chronic pain exhibited higher P50 and N100 amplitudes compared to pain‐free older adults but displayed typical age‐related flattening during P300.ConclusionsThese findings indicate that chronic pain leads to a decline in the ability to habituate to non‐painful irrelevant somatosensory stimuli, especially when it is presented in an emotional context.Significance StatementIn the present study, we have observed how older individuals suffering from chronic pain exhibit a decline in the habituation capacity of irrelevant somatosensory information. Furthermore, we have observed how the affective context in which these individuals are situated leads to an exacerbation of this deficit. Enhancing our comprehension of how aging and chronic pain interact to impact somatosensory processing could facilitate the tailoring of novel intervention strategies.