bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Return to Sport Following Distal Femoral Varus Osteotomy
Authors: Voleti Pramod B. , Wu Isabella T. , Degen Ryan M. , Tetreault Danielle M. , Krych Aaron J. , Williams Riley J. 
Published: December 2017

Objective Distal femoral varus osteotomy (DFVO) is an effective treatment for unloading valgus knee malalignment; however, there is limited evidence on the ability for patients to return to athletics following this procedure. The purpose of this study is to report the functional outcomes and rate of return to sport for athletes that underwent DFVO. Design A consecutive series of athletes that had undergone DFVO were retrospectively reviewed. Radiographs were assessed to determine preoperative and postoperative alignment. Institutional registries were used to collect preoperative and postoperative Marx Activity Scale, International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form scores, and return to sport. Results Thirteen patients (8 males, 5 females) with a mean age of 24 years (range 17-35 years) and a mean follow-up of 43 months (range 24-74 months) were included in the study. Six patients underwent medial closing wedge DFVO versus 7 patients who underwent lateral opening wedge DFVO. Nine of 13 had concomitant chondral, meniscal, or ligamentous procedures performed. The mean alignment correction was 8° (range 5°-13°). All patients were able to successfully return to sport at a mean of 11 months (range 9-13 months). Furthermore, all 13 patients demonstrated an improvement in both Marx Activity Scale (4-11; P < 0.01) and IKDC scores (53-89; P < 0.01) after surgery. Conclusions Correction of valgus knee malalignment through DFVO—either medial closing wedge or lateral opening wedge—can reliably result in improvement in function and return to sport. Concomitant chondral, meniscal, and ligamentous pathology should be addressed.
An Innovative Laboratory Procedure to Expand Chondrocytes with Reduced Dedifferentiation
Authors: Mao Yong , Hoffman Tyler , Wu Amy , Kohn Joachim 
Published: December 2017

Objective In vitro expansion of chondrocytes is required for cartilage tissue engineering and clinical cell-based cartilage repair practices. However, the dedifferentiation of chondrocytes during in vitro expansion continues to be a challenge. This study focuses on identifying a cell culture surface to support chondrocyte expansion with reduced dedifferentiation. Design A less adhesive culture surface, non–tissue culture treated surface (NTC), was tested for its suitability for culturing chondrocytes. The cell expansion and the expression of chondrocyte markers were monitored for at least 2 passages on NTC in comparison with conventional tissue culture treated polystyrene surface (TCP). The ability of expanded chondrocytes to form cartilage tissues was evaluated using pellet culturing and subcutaneous implantation in nude mice. Results NTC supported bovine chondrocyte proliferation to a clinically relevant expansion requirement within 2 passages. Chondrocyte phenotypes were better maintained when cultured on NTC than on TCP. In vitro pellet culture studies showed that chondrocytes expanded on NTC expressed a higher level of chondrocyte extracellular matrix. Furthermore, the cells expanded on NTC or TCP were implanted subcutaneously as pellets in nude mice for 6 weeks. The recovered pellets showed cartilage-like tissue formation from cells expanded on NTC but not from the cells expanded on TCP. Conclusions This study presents an innovative and easy culturing procedure to expand chondrocytes with reduced dedifferentiation. This procedure has potential to be developed to expand chondrocytes in vitro for basic research, tissue engineering, and possibly for clinical applications.
Diffusion-weighted imaging of normal appearing corticospinal tracts in patients with multiple sclerosis
Authors: Yalçın-Şafak Kadihan , Akça Ahmet , Elibol Özlem , Sarı İrem 
Published: December 2017

Aim To determine if there are differences in ADC values between normal appearing corticospinal tracks in patients with MS compared to ADC values in controls. Material and methods The study population comprised 62 consecutive MS patients (36 women and 26 men; mean age 36.45±8.63 years). 50 control subjects with no neurological disabilities or intracranial were included the study (32 women and 18 men; mean age 40.18±12.25 years). All ADC maps were independently evaluated by two experienced radiologists. ROI of approximately 15–18 mm2 in capsula interna and 10–12 mm2 in mesencephalon were placed bilaterally for measurement of ADC values. Three circular ROIs were placed-one each side for internal capsule-and 6 total ROIs from right and left internal capsule were averaged for each patient. Mesencephelon ADC measurements were performed similarly. Result The mean ADC values of the left internal capsule in MS patients were significiantly lower than the control group (p:0.002). No statistically significant difference was found between the MS patients and control group mean ADC values of the right internal capsule (p>0.05). The mean ADC values of the right and left mesencephalon in MS patients were significiantly lower than the control group (respectively; p:0.031, p<0.001). The mean ADC values of the left internal capsule were significiantly lower than the right internal capsule in MS patients (p<0.001). The mean ADC values of the left mesencephalon were significiantly lower than the right mesencephalon in MS patients (p<0.001). Conclusion The mean ADC values of the normal-appearing corticospinal tract in MS patients were significantly lower than the control group except for the right internal capsule.
Physical condition, nutritional status, fatigue, and quality of life in oncological out-patients
Authors: Schulz Karl-Heinz , Patra Stefan , Spielmann Hannah , Klapdor Silke , Schlüter Kathrin , van Eckert Sandra 
Published: December 2017

Objective: Early detection of limited physical activity and nutritional deficiencies in cancer survivors could contribute to early treatment and preservation of quality of life. The aim of this study is to describe the association of physical condition and nutritional status with fatigue and quality of life in oncological out-patients. Methods: Data in this descriptive study was collected on bioelectrical impedance analysis, postural stability (stability index), body mass index, Karnofsky Index, quality of life (Short-Form 36-Item Health Survey) and fatigue (multidimensional fatigue inventory-20) in a consecutive sample of 203 oncological out-patients. Phase angle was calculated from bioelectrical impedance analysis. Values were intercorrelated and compared to appropriate standard values. Results: Phase angle and stability index outcomes were far below the values of a healthy population of similar age (p < 0.001). Quality of life was significantly lower than in the normal population (p < 0.001), and the level of fatigue was significantly higher (p < 0.001). Phase angle correlated with Karnofsky Index (p = 0.002) and Short-Form 36-Item Health Survey Summary physical function (p < 0.001). Furthermore, multidimensional fatigue inventory-20 scales ‘physical fatigue’ and ‘reduced activity’ were significantly associated with phase angle (p = 0.04, p = 0.005). Stability indices correlated with Short-Form 36-Item Health Survey physical function. Conclusion: The physical condition and the nutritional status are key components determining the individual quality of life of oncological out-patients. These variables also showed an association with the manifestation of fatigue. Results highlight the need for interdisciplinary cooperation to detect physical, nutritional and psychological deficiencies in oncological out-patients.
Venous Thromboembolism Within Professional American Sport Leagues
Authors: Bishop Meghan , Astolfi Matthew , Padegimas Eric , DeLuca Peter , Hammoud Sommer 
Published: December 2017

Background: Numerous reports have described players in professional American sports leagues who have been sidelined with a deep vein thrombosis (DVT) or a pulmonary embolism (PE), but little is known about the clinical implications of these events in professional athletes. Purpose: To conduct a retrospective review of injury reports from the National Hockey League (NHL), Major League Baseball (MLB), the National Basketball Association (NBA), and the National Football League (NFL) to take a closer look at the incidence of DVT/PE, current treatment approaches, and estimated time to return to play in professional athletes. Study Design: Descriptive epidemiology study. Methods: An online search of all team injury and media reports of DVT/PE in NHL, MLB, NBA, and NFL players available for public record was conducted by use of Google, PubMed, and SPORTDiscus. Searches were conducted using the professional team name combined with blood clot, pulmonary embolism, and deep vein thrombosis. Results: A total of 55 venous thromboembolism (VTE) events were identified from 1999 through 2016 (NHL, n = 22; MLB, n = 16; NFL, n = 12; NBA, n = 5). Nineteen athletes were reported to have an upper extremity DVT, 15 had a lower extremity DVT, 15 had a PE, and 6 had DVT with PE. Six athletes sustained more than 1 VTE. The mean age at time of VTE was 29.3 years (range, 19-42 years). Mean (±SD) time lost from play was 6.7 ± 4.9 months (range, 3 days to career end). Seven athletes did not return to play. Players with upper extremity DVT had a faster return to play (mean ± SD, 4.3 ± 2.7 months) than those with lower extremity DVT (5.9 ± 3.8 months), PE (10.8 ± 6.8 months), or DVT with PE (8.2 ± 2.6 months) ( F = 5.69, P = .002). No significant difference was found regarding time of return to play between sports. Conclusion: VTE in professional athletes led to an average of 6.7 months lost from play. The majority of athletes were able to return to play after a period of anticoagulation or surgery. Those with an upper extremity DVT returned to play faster than those with other types of VTE. Further study is needed to look into modifiable risk factors for these events and to establish treatment and return-to-play guidelines to ensure the safety of these athletes.
Identification of jellyfish neuropeptides that act directly as oocyte maturation-inducing hormones
Authors: Takeda Noriyo , Kon Yota , Quiroga Artigas Gonzalo , Lapébie Pascal , Barreau Carine , Koizumi Osamu , Kishimoto Takeo , Tachibana Kazunori , Houliston Evelyn , Deguchi Ryusaku 
Published: December 2017

ABSTRACT
Oocyte meiotic maturation is crucial for sexually reproducing animals, and its core cytoplasmic regulators are highly conserved between species. By contrast, the few known maturation-inducing hormones (MIHs) that act on oocytes to initiate this process are highly variable in their molecular nature. Using the hydrozoan jellyfish species Clytia and Cladonema, which undergo oocyte maturation in response to dark-light and light-dark transitions, respectively, we deduced amidated tetrapeptide sequences from gonad transcriptome data and found that synthetic peptides could induce maturation of isolated oocytes at nanomolar concentrations. Antibody preabsorption experiments conclusively demonstrated that these W/RPRPamide-related neuropeptides account for endogenous MIH activity produced by isolated gonads. We show that the MIH peptides are synthesised by neural-type cells in the gonad, are released following dark-light/light-dark transitions, and probably act on the oocyte surface. They are produced by male as well as female jellyfish and can trigger both sperm and egg release, suggesting a role in spawning coordination. We propose an evolutionary link between hydrozoan MIHs and the neuropeptide hormones that regulate reproduction upstream of MIHs in bilaterian species.
Changes in acceptance and suppression of negative
and positive emotions in patients with depressive
disorders: a longitudinal study
Authors: Pastuszak-Draxler Anna , Gierowski Józef Krzysztof 
Published: December 2017

Aim of the studyDifficulties with emotion regulation can be found in most mental disorders. However, we know little about the changes in negative and positive emotions during the treatment process. The presented longitudinal study, therefore focuses such changes and investigates acceptance and suppression, separately for negative and positive emotions during the treatment process.
The goals were to investigate if there is a measurable change of acceptance and suppression of negative and positive emotions during the course of treatment of depressive patients and to investigate how the results of such patients at the end of their treatment compare to those of healthy controls.Subject or material and methodsSubjects were 40 depressive patients and 29 healthy controls. The Beck-Depression-Inventory and the State-Trait-Anxiety Inventory were used to assess the level of symptoms. The Emotion Acceptance Questionnaire - to assess acceptance and suppression of negative and positive emotions - was used twice: once at the beginning and once at the end of the inpatients’ treatment.ResultsDepressive patients reported reduced acceptance of positive and negative emotions compared to controls, but they additionally suppressed emotions more intensively. Suppression of negative and positive emotions throughout the study was related to the level of depression and anxiety symptoms.DiscussionThe analysis showed a significant improvement of emotion regulation strategies, towards the end of treatment. However, patients did not reach the same level of capabilities as healthy controls.ConclusionsFor future research, we suggest to extend the study by observing the specifics of emotion regulation changes over a longer period of time.
Devon air ambulance: a case example
Authors: Holt Heléna 
Published: December 2017

The first thing a patient in need of emergency treatment may recognize is the red flight suit of a South Western Ambulance Service NHS paramedic operating from the Devon Air Ambulance. This would be one of the specially trained and highly committed band of 12 full time paramedics who work on the air ambulance. While each of these air crew paramedics will insist that the bright red helicopter is treated just the same as any other ambulance, but one with rotor blades instead of tyres, each appears to have forged a special relationship with the work of the Devon Air Ambulance Trust and each supports it in a variety of ways above and beyond the call of duty
Mechanism of ligand binding – PDZ domain taken as example
Authors: Dułak Dawid , Banach Mateusz , Wiśniowski Zdzisław , Konieczny Leszek , Roterman Irena 
Published: December 2017

Abstract
The mechanism of specific ligand binding by proteins is discussed using the PDZ domain complexing the pentapeptide. This process is critical for clustering the membrane ion channel. The traditional model based on the Beta-sheet extension by complexed pentapeptide is interpreted as a hydrophobic core extension supported by additional Beta-strand generated by complexed pentapeptide. The explanation is based on the fuzzy oil drop model applied to the crystal structure of PDZ-pentapeptide.
Expansion for cubes in the Heisenberg group
Authors: Hegyvári Norbert , Hennecart François 
Published: December 2017

Abstract
In the last decade the growth in groups focused the interest of many researchers in the domain of additive combinatorics.
In this note, we investigate the special case of the Heisenberg group

ℋ

{\mathcal{H}}

of order 3 on different fields R, namely,

R
=
𝐑

{R=\mathbf{R}}

and

R
=

𝐅
p

{R=\mathbf{F}_{p}}

.
Denoting by

[
x
,
y
,
z
]

{[x,y,z]}

the elements of

ℋ

{\mathcal{H}}

, a cube is a subset of the type

[
A
,
B
,
C
]

{[A,B,C]}

, with

A
,
B
,
C

⊂
R

{A,B,C\subset R}

.
This study relies to the well-known sum-product problem and its extensions, from which we obtain strong lower bounds for the size of the square

[
A
,
B
,
C
]

2

{[A,B,C]^{2}}

of cubes in

ℋ

{\mathcal{H}}

.
In the final section, we also consider the problem of counting the subsets of

ℋ

{\mathcal{H}}

of the type

[
A
,
B
,
C
]

2

{[A,B,C]^{2}}

.
Insomnia and depression: Japanese hospital workers questionnaire survey
Authors: Koyama Fumihiko , Yoda Takeshi , Hirao Tomohiro 
Published: December 2017

Abstract

Objectives
This study aimed to identify a correlation between insomnia and the occurrence of depression among Japanese hospital employees using the data obtained from a self-reported questionnaire.

Methods
A self-administered questionnaire on sleeping patterns, depression, fatigue, lifestyle-related diseases, and chronic pain was given to 7690 employees aged 20-60 years, and 5,083 employees responded.

Results
An insomnia score of >2 was observed in 840 (13%) respondents. Chronic insomnia correlated significantly with gender, occupation, overtime work, metabolic syndrome, chronic pain, fatigue, and depression. Moreover, significant negative effects on depression scores were observed in males aged 30-39 (partial regression coefficient: b=0.357, p=0.016), females aged 20-29 (b=0.494, p<0.001), male administrative staff (b=0.475, p=0.003), males with metabolic syndrome (b=0.258, p=0.023), and both genders with chronic insomnia (male; b=0.480, p<0.001: female; b=0.485, p<0.001), and fatigue (male; b=1.180, p<0.001: female; b=1.151, p<0.001).

Discussion
Insomnia is a risk factor for depression and for other lifestyle-related diseases. The insomnia score may be useful in preventative care settings because it is associated with a wide spectrum of diseases and serves as a valuable marker for early detection of depression. Thus, our future studies will focus on establishing a method for early detection of depression symptoms among workers across various job profiles.
Rare earth-rich cadmium compounds RE
10
TCd3 (RE=Y, Tb, Dy, Ho, Er, Tm, Lu; T=Rh, Pd, Ir, Pt) with an ordered Co2Al5-type structure
Authors: Block Theresa , Klenner Steffen , Heletta Lukas , Pöttgen Rainer 
Published: December 2017

Abstract
Eighteen new rare earth-rich intermetallic phases RE
10
TCd3 (RE=Y, Tb, Dy, Ho, Er, Tm, Lu; T=Rh, Pd, Ir, Pt) were obtained by induction melting of the elements in sealed niobium ampoules followed by annealing in muffle furnaces. All samples were characterized by X-ray powder diffraction. The structures of four representatives were refined from single-crystal X-ray diffractometer data: ordered Co2Al5 type, P63/mmc, a=951.2(1), c=962.9(2) pm, wR=0.0460, 595 F
2 values, 20 parameters for Er10RhCd3; a=945.17(4), c=943.33(4), wR=0.0395, 582 F
2 values, 21 parameters for Lu9.89PdCd3.11; a=964.16(6), c=974.93(6) pm, wR=0.0463, 614 F
2 values, 21 parameters for Y10Ir1.09Cd2.91; a=955.33(3), c=974.56(3) pm, wR=0.0508, 607 F
2 values, 22 refined parameters for Dy9.92IrCd3.08. Refinements of the occupancy parameters revealed small homogeneity ranges resulting from RE/Cd, respectively T/Cd mixing. The basic building units of the RE
10
TCd3 phases are transition metal-centered RE
6 trigonal prisms (TP) that are condensed with double-pairs of empty RE
6 octahedra via common triangular faces. A second type of rods is formed by slightly distorted RE3@Cd6
RE
6 icosahedra which are condensed via Cd3 triangular faces. The shortest interatomic distances occur for RE–T, compatible with strong covalent bonding interactions. Temperature dependent magnetic susceptibility measurements were performed for RE
10RhCd3 (RE=Dy–Tm, Lu), RE
10IrCd3 (RE=Er, Tm, Lu) and RE
10PtCd3 (RE=Y, Lu). While Y10PtCd3 and Lu10
TCd3 (T=Rh, Ir, Pt) show Pauli paramagnetic behavior, the compounds containing paramagnetic rare earth elements show Curie-Weiss behavior (the experimental magnetic moments indicate stable trivalent RE
3+) and magnetic ordering at low temperatures: T
C=80.5 K for Dy10RhCd3 and Neél temperatures of 42.1, 23.3, 12.6, 5.9, 10.0 K for Ho10RhCd3, Er10RhCd3, Er10IrCd3, Tm10RhCd3, Tm10IrCd3, respectively.
Changes in bone marrow in malaria-a prospective study of 47 cases
Authors: Rastogi Nupur , Rehman Neha 
Published: December 2017

Background: Bone marrow aspiration done in cases of repeated fever, fever of unknown origin, pancytopenia to detect Malaria parasite in bone marrow. The study was undertaken to evaluate the role of bone marrow aspiration in establishing the etiology of Plasmodium vivax in cases of pancytopenia or thrombocytopenia in recurrent fever or fever of unknown origin.Methods: Patients of different age groups presenting with recurrent fever or fever of unknown origin with pancytopenia or thrombocytopenia from Jan 2015 to Oct 2017. Out of the 108 bone marrow aspirations abiding the above criteria 47 showed presence of Plasmodium vivax trophozoites in bone marrow.Results: The age of patients varied from 8 months to 65 years. 47 cases showed presence of Plasmodium vivax trophozoites, mainly with hyperplastic marrow showing normoblastic and megaloblastic hyperplasia, presence of hemophagocytosis in 6 cases and also 2 cases showing increase in plasma cells.Conclusions: Bone marrow aspiration studies are of vital importance in diagnosing malarial infection in endemic areas as being one of the cause of pancytopenia or thrombocytopenia.
A study to assess awareness about HIV/AIDS among rural population of central India
Authors: Kawale Shailesh K. , Sharma Vivek , Thaware Prafulla P. , Mohankar Atul D. 
Published: December 2017

Background: Prevention and control of HIV/AIDS depends on general knowledge and attitude towards HIV/AIDS. So the present study was conducted with the aim to assess knowledge, attitude, and preventive practices regarding HIV infection and AIDS among rural peoples.Methods: A cross sectional study was conducted among peoples age more than 15 years in a villages which comes under field practice area of rural health training centre (RHTC) of our medical college. Total 396 individuals were interviewed during March 2015 to April 2015 by using predesigned and pretested questionnaire after taking written informed consent.Results: 71.5% knows uninfected faithful partner and 82.1% thinks use of condom will prevent transmission of HIV/AIDS to their partners. 46.7% thinks mosquito bite, 37.6% thinks sharing food transmit HIV/AIDS. 83.1% knows pregnancy and 79.3% knows breastfeeding transmit HIV to their children. 61.1% willing for not to keep HIV status secret, 81.6% willing to take care of relatives having HIV, 88.6% allow HIV positive teachers to continue teaching and 68.4% will buy vegetables from HIV positive shopkeeper. 36.8% knows nearby place where condoms are available and 49.7% knows nearby place for HIV testing.Conclusions:People have good knowledge about HIV transmission i.e. faithful partner, condom use, pregnancy and breast feeding. Still some misconceptions need to be address regarding mosquito bite and sharing food with person having HIV/AIDS. Participants have poor knowledge about nearby availability of services related to HIV/AIDS.