bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pricing and Mispricing of Accounting Fundamentals in the Time‐Series and in the Cross Section
Authors: Nichols D. Craig , Wahlen James M. , Wieland Matthew M. 
Published: May 2017

AbstractThis study examines the extent to which parsimonious and general cross‐sectional valuation models, restricted to include only publicly available historical accounting information, explain share prices in the cross section, identify periods when market mispricing may be more pervasive, and also identify which shares within those cross sections are more likely to be mispriced. Our model simply includes historical book value, earnings, dividends, and growth, but it explains on average over 60 percent of the cross‐sectional variation in share prices in annual estimations across 1975–2011. We also examine the extent to which the residuals indicate mispricing. The quintile of stocks picked by our model as most likely underpriced outperform the quintile of stocks picked as most likely overpriced by an average of 9.9 percent over the following 12 months, after controlling for size. We also predict and find that value residuals are better predictors of future abnormal returns: (i) among firms that are not covered by analysts; (ii) among firms that face fewer accounting measurement challenges; and (iii) when we estimate value model parameters by industry/year. We also predict and find our approach works better in periods when the mapping of fundamentals into prices is weaker. This study contributes a novel and straightforward approach to map accounting fundamentals into share prices in order to identify mispricing in time‐series and in the cross section.
Effects of sleep on substance use in adolescents: a longitudinal perspective
Authors: Nguyen‐Louie Tam T. , Brumback Ty , Worley Matthew J. , Colrain Ian M. , Matt Georg E. , Squeglia Lindsay M. , Tapert Susan F. 
Published: May 2017

AbstractSubstance use (SU) and sleep problems appear interrelated, but few studies have examined the influence of adolescent sleep patterns on development of SU disorders. This study prospectively examined the influence of sleep habits on subsequent SU in youth who later transitioned into heavy drinking. At time 1 (T1), participants (n = 95) were substance‐naive 12‐ to 14‐year‐olds. Path‐analytic models examined whether the effects of T1 risk factors (familial SU disorder, inhibition control, and externalizing and internalizing traits) on time 3 (M = 19.8 years old) tobacco, alcohol, and cannabis were mediated by time 2 (M = 15.1 years old) sleep chronotype, daytime sleepiness, and erratic sleep/wake behaviors. Significant direct path effects of T1 risk factors and time 2 sleep behaviors on time 3 SU were found, Ps < 0.05. In models that examined the effect of each individual sleep behavior separately on SU, more erratic sleep/wake and greater daytime sleepiness predicted higher lifetime use events for all substances (Ps < 0.01). Higher evening chronotype tendencies predicted lower tobacco and higher alcohol and cannabis lifetime use events (Ps < 0.01). Erratic sleep/wake behaviors mediated the effect of inhibitory control on subsequent SU; less erratic sleep/wake behaviors predicted better inhibition control (
= −0.20, P < 0.05). Early‐mid adolescent psychiatric health and sleep behaviors prior to drinking onset predicted greater SU 5 years later. Participants were substance‐naïve at baseline, allowing for the examination of temporal order in the relationship between sleep problems and alcohol use. Early adolescent sleep problems may be an important risk factor for SU in later life.
Nucleus accumbens functional connectivity at age 20 is associated with trajectory of adolescent cannabis use and predicts psychosocial functioning in young adulthood
Authors: Lichenstein Sarah D. , Musselman Samuel , Shaw Daniel S. , Sitnick Stephanie , Forbes Erika E. 
Published: May 2017

AbstractAims(1) To identify trajectories of cannabis use across adolescence, (2) to measure the influence of cannabis use characteristics on functional connectivity of the nucleus accumbens (NAcc) and (3) to assess whether patterns of functional connectivity related to cannabis use are associated with psychosocial functioning 2 years later.DesignThe Pitt Mother and Child Project (PMCP) is a prospective, longitudinal study of male youth at high risk for psychopathology based on family income and gender.SettingParticipants were recruited between age 6 and 17 months from the Women, Infants and Children Nutritional Supplement program (WIC) in the Pittsburgh, Pennsylvania area.ParticipantsA total of 158 PMCP young men contributed functional magnetic resonance imaging (fMRI) and substance use data at age 20 years.MeasurementsLatent class growth analysis was used to determine trajectories of cannabis use frequency from age 14 to 19 years. Psychophysiological interaction (PPI) analysis was used to measure functional connectivity between the NAcc and prefrontal cortex (PFC). Adolescent cannabis use trajectory, recent frequency of use and age of initiation were considered as developmental factors. We also tested whether functional connectivity was associated with depressive symptoms, anhedonia and educational attainment at age 22.FindingsWe identified three distinct trajectories of adolescent cannabis use, characterized by stable high, escalating or stable low use. The cannabis use trajectory group had a significant effect on NAcc functional connectivity to the medial PFC (F = 11.32, Z = 4.04, Pfamily‐wise error‐corrected (FWE‐corr) = 0.000). The escalating trajectory group displayed a pattern of negative NAcc‐mPFC connectivity that was linked to higher levels of depressive symptoms (r = –0.17, P < .05), anhedonia (r = –0.19, P < .05) and lower educational attainment (t = –2.77, P < .01) at age 22.ConclusionsPattern of cannabis use frequency across adolescence in US youth could have consequences for mood symptoms and educational attainment in early adulthood via altered function in neural reward circuitry.
Malnutrition risk of older people across district health board community, hospital and residential care settings in New Zealand
Authors: Wham Carol , Fraser Emily , Buhs‐Catterall Julia , Watkin Rebecca , Gammon Cheryl , Allen Jacqui 
Published: May 2017

ObjectiveTo determine the prevalence of malnutrition risk in older people across three settings.MethodsOlder people living in the community or newly admitted to hospital or residential care were assessed for malnutrition risk using the validated Mini‐Nutritional Assessment – Short Form and dysphagia risk using the Eating Assessment Tool‐10. Demographic, physical and health data were collected.ResultsOf 167 participants, 23% were malnourished and 35% were at high risk of malnutrition. Those recently admitted to residential care versus a hospital or living in the community had a higher prevalence of malnourishment (47% vs 23% and 2%) (P < 0.001). Risk of dysphagia differed with settings (P < 0.001) with highest risk in residential care. Hospitalised and residential care participants were significantly more likely to have ≥4 comorbidities, take ≥5 medications and have below normal cognition compared to community participants.ConclusionChoice of nutrition intervention is setting dependent.
Projections of the number of Australians with disability aged 65 and over eligible for the National Disability Insurance Scheme: 2017–2026
Authors: Biddle Nicholas , Crawford Heather 
Published: May 2017

ObjectiveTo develop projections of the size of the Australian population aged 65 years and over eligible for disability support through the National Disability Insurance Scheme (NDIS) for the decade following its introduction, to support planning and costing of the scheme.MethodsWe estimate disability and mortality transition probabilities and develop projections of the NDIS‐eligible, ageing population from 2017 to 2026.ResultsAn estimated 8000 men and 10 200 women aged 65 years and over will be eligible for support through the NDIS in 2017 (the scheme's first full year), increasing to 48 800 men and 56 900 women in 2026.ConclusionsGrowth in the NDIS‐eligible, ageing population has implications for relative budget allocations between the NDIS and the aged‐care system, and projections of the size of this population are useful for calculating the overall cost of the NDIS.
Conservation value of disturbed and secondary forests for ferns and lycophytes along an elevational gradient in Mexico
Authors: Carvajal‐Hernández César I. , Krömer Thorsten , López‐Acosta Juan Carlos , Gómez‐Díaz Jorge A. , Kessler Michael 
Published: May 2017

AbstractQuestionsHow do species richness and composition of fern assemblages change with elevation and, within elevational belts, in differently impacted forest habitats? Is there a relationship between fern assemblages and microclimate, both along gradients of elevation and disturbance? Which species are most sensitive to habitat disturbance and microclimatic changes?LocationFrom sea level close to the Gulf of Mexico 81 km away in a direct line on the eastern slopes of the Cofre de Perote at 3500 m, central Veracruz, Mexico.MethodsWe studied the richness and composition of fern assemblages in 120 study plots at eight elevations from 20–3500 m in three forest types: natural forest (NF), disturbed forest (DF) subjected to timber extraction and grazing, and secondary forest (SF) regrown after total clearance 15–20 yr ago. In addition, we measured microclimatic conditions in the three forest types at five elevations over a year.ResultsFern richness peaked in humid montane forests at mid‐elevations and was low in the drier habitats at the ends of the gradient. Humid montane forests were most sensitive to disturbance, showing increases in mean annual temperatures by about 1 °C and reduction in relative air humidity by about 20% in DF and SF compared to NF. This was together with a reduction in fern species richness of 5–60% and marked changes in species composition. In contrast, drought‐deciduous forests at low elevations and coniferous forests at high elevations already had low humidity and high light intensity in NF and were less affected by human impact: their microclimatic conditions and fern assemblages did not change markedly in DF and SF.ConclusionsThe conservation of much of the humidity‐dependent biota (ferns and presumably also groups such as bryophytes and amphibians) in humid montane forests depends on the protection of natural fragments without human disturbance. In contrast, the naturally open forests at the ends of the gradient can be subjected to some exploitation while conserving much of their fern flora as long as a general forest structure is maintained.
Initial multicentre experience of 68gallium‐PSMA PET/CT guided robot‐assisted salvage lymphadenectomy: acceptable safety profile but oncological benefit appears limited
Authors: Siriwardana Amila , Thompson James , van Leeuwen Pim J. , Doig Shaela , Kalsbeek Anton , Emmett Louise , Delprado Warick , Wong David , Samaratunga Hemamali , Haynes Anne‐Maree , Coughlin Geoff , Stricker Phillip 
Published: May 2017

ObjectivesTo evaluate the safety and short‐term oncological outcomes of 68gallium‐labelled prostate‐specific membrane antigen (68Ga‐PSMA) positron‐emission tomography (PET)/computed tomography (CT)‐directed robot‐assisted salvage node dissection (RASND) for prostate cancer oligometastatic nodal recurrence.Materials and MethodsBetween February 2014 and April 2016, 35 patients across two centres underwent RASND for 68Ga‐PSMA PET/CT‐detected oligometastatic nodal recurrence. RASND was performed using targeted pelvic dissection, unilateral extended pelvic template or bilateral extended pelvic template dissection, depending on previous pelvic treatment and extent/location of nodal disease. Complications were reported using the Clavien–Dindo classification system. Definitions of prostate‐specific antigen (PSA) treatment response to RASND were defined as 6‐week PSA <0.2 ng/mL (broad definition) or PSA <0.05 ng/mL (strict definition) in those who had undergone primary prostatectomy, and 6‐week PSA level < post‐radiotherapy nadir in those who had undergone primary radiotherapy. Biochemical recurrence (BCR) after RASND was defined as a PSA >0.2 ng/mL or PSA > nadir, for those who had undergone primary prostatectomy and primary radiotherapy, respectively. Predictors of treatment response were analysed using univariate binary logistic regression.ResultsA total of 58 lesions suspicious for lymph node metastases (LNM) in 35 patients were detected on 68Ga‐PSMA imaging. A total of 32 patients (91%) had histopathologically proven LNM at RASND, with a total of 87 LNM and a median (interquartile range) of 2 (1–3) LNM per patient. In all, eight patients (23%) experienced complications, all Clavien–Dindo grade ≤2. Treatment response was seen in 15 (43%) and 11 patients (31%), using the broad and strict definitions, respectively. BCR‐free survival and clinical recurrence‐free survival at a median follow‐up of 12 months were 23% and 66%, respectively, for the entire cohort. Bilateral template dissection was the only significant univariate predictor of treatment response in our cohort.ConclusionsAlthough RASND appears safe and feasible, less than half of our cohort had a treatment response, and less than a quarter experienced BCR‐free survival at 12‐month median follow‐up. 68Ga‐PSMA imaging underestimates micro‐metastatic disease, therefore RASND will rarely be curative. Strict patient selection and restricting RASND to clinical trials is recommended. Long‐term follow‐up from such trials is required to further assess potential quality of life and mortality benefits.
Endoplasmic reticulum stress in the heart: insights into mechanisms and drug targets
Authors: Wang Shunyao , Binder Pablo , Fang Qiru , Wang Zhenzhong , Xiao Wei , Liu Wei , Wang Xin 
Published: May 2017

The endoplasmic reticulum (ER) serves several essential cellular functions including protein synthesis, protein folding, protein translocation, calcium homoeostasis and lipid biosynthesis. Physiological or pathological stimuli, which disrupt ER homoeostasis and disturb its functions, lead to an accumulation of misfolded and unfolded proteins, a condition referred to as ER stress. ER stress triggers the unfolded protein response to restore the homoeostasis of ER, through activating transcriptional and translational pathways. However, prolonged ER stress will lead to cell dysfunction and apoptosis. Recent evidence revealed that ER stress is involved in the development and progression of various heart diseases, such as cardiac hypertrophy, ischaemic heart diseases and heart failure. Therefore, improved understanding of the molecular mechanisms of ER stress in heart disease will help to investigate more potential targets for new therapeutic interventions and drug discovery.Linked ArticlesThis article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc
Development of protein degradation inducers of oncogenic BCR‐ABL protein by conjugation of ABL kinase inhibitors and IAP ligands
Authors: Shibata Norihito , Miyamoto Naoki , Nagai Katsunori , Shimokawa Kenichiro , Sameshima Tomoya , Ohoka Nobumichi , Hattori Takayuki , Imaeda Yasuhiro , Nara Hiroshi , Cho Nobuo , Naito Mikihiko 
Published: May 2017

Chromosomal translocation occurs in some cancer cells, which results in the expression of aberrant oncogenic fusion proteins that include BCR‐ABL in chronic myelogenous leukemia (CML). Inhibitors of ABL tyrosine kinase, such as imatinib and dasatinib, exhibit remarkable therapeutic effects, although emergence of drug resistance hampers the therapy during long‐term treatment. An alternative approach to treat CML is to downregulate the BCR‐ABL protein. We have devised a protein knockdown system by hybrid molecules named Specific and Non‐genetic inhibitor of apoptosis protein [IAP]‐dependent Protein Erasers (SNIPER), which is designed to induce IAP‐mediated ubiquitylation and proteasomal degradation of target proteins, and a couple of SNIPER(ABL) against BCR‐ABL protein have been developed recently. In this study, we tested various combinations of ABL inhibitors and IAP ligands, and the linker was optimized for protein knockdown activity of SNIPER(ABL). The resulting SNIPER(ABL)‐39, in which dasatinib is conjugated to an IAP ligand LCL161 derivative by polyethylene glycol (PEG) × 3 linker, shows a potent activity to degrade the BCR‐ABL protein. Mechanistic analysis suggested that both cellular inhibitor of apoptosis protein 1 (cIAP1) and X‐linked inhibitor of apoptosis protein (XIAP) play a role in the degradation of BCR‐ABL protein. Consistent with the degradation of BCR‐ABL protein, the SNIPER(ABL)‐39 inhibited the phosphorylation of signal transducer and activator of transcription 5 (STAT5) and Crk like proto‐oncogene (CrkL), and suppressed the growth of BCR‐ABL‐positive CML cells. These results suggest that SNIPER(ABL)‐39 could be a candidate for a degradation‐based novel anti‐cancer drug against BCR‐ABL‐positive CML.
Examining the psychological and social impact of relative age in primary school children: a cross‐sectional survey
Authors: Price A. , Allen K. , Ukoumunne O. C. , Hayes R. , Ford T. 
Published: May 2017

SummaryBackgroundA number of studies demonstrate that children who are younger within their school year have poorer academic attainment and are more likely to have special educational needs. Few, however, have considered the impact relative age may have on child mental health, behaviour and happiness in school.MethodsThis paper utilized data from the Supporting Teachers and Children in Schools study (2075 pupils aged 5 to 9 years from 80 primary schools) to explore the relationship among relative age, behaviour and happiness in school. Behavioural and emotional development was assessed by using the teacher‐reported and parent‐reported Strengths and Difficulties Questionnaire and the Pupil Behaviour Questionnaire. Children's happiness within school was assessed by using the How I Feel About My School Questionnaire.ResultsRelatively younger children had higher Total Difficulties scores on the Strengths and Difficulties Questionnaire than their peers. There was a mean increase per 30‐day decrease in relative age of 0.09 (95% CI: 0.03 to 0.16; p = 0.007) in teacher‐reported and 0.08 (0.001 to 0.16; p = 0.05) in parent‐reported scores. There was little evidence of a relationship between relative age and children's behaviour and happiness in school.ConclusionsFor children with complex difficulties, being relatively young for their school year may be an additional stressor that may undermine mental health.
Sequential Associations Between Caregiver Talk and Child Play in Autism Spectrum Disorder and Typical Development
Authors: Bottema‐Beutel Kristen , Malloy Caitlin , Lloyd Blair P. , Louick Rebecca , Joffe‐Nelson Linnea , Watson Linda R. , Yoder Paul J. 
Published: May 2017

This study examined sequential associations between child play and caregiver talk in 98 caregiver–child dyads (Mmental age = 14 months). Fifty dyads included a child with autism spectrum disorder (ASD). Analyses revealed sequential associations between child play and caregiver follow‐in (FI) utterances (utterances related to the child's attentional focus) were stronger in the ASD as compared to the typically developing (TD) group. FI utterances were more likely to elicit functional play than caregiver‐focused utterances, and more so in the ASD group. Across groups, FI directives were more likely to elicit functional play than FI comments. These findings have important implications for research involving caregiver–child play as an early intervention context for children with ASD.
The additional utility of two‐dimensional strain in detection of coronary artery disease presence and localization in patients undergoing dobutamine stress echocardiogram
Authors: Roushdy Alaa , Abou el Seoud Yomna , Abd Elrahman Mohamed , Wadeaa Basem , Eletriby Adel , Abd el Salam Zainab 
Published: May 2017

BackgroundDobutamine stress echocardiogram (DSE) is a feasible and safe exercise‐independent stress modality for diagnoses of coronary artery disease (CAD), but it is subjective, and operator dependant. Two‐dimensional strain at peak stress could overcome these limitations and thus increase the accuracy of DSE.Methods and ResultsThis was a prospective observational study in which 80 patients underwent DSE, two‐dimensional strain at peak stress, and coronary angiography. Global longitudinal strains (GLS) cutoff point of −16.75 had 77.42% sensitivity and 83.33% specificity to detect significant CAD. Global circumferential strain (GCS) cutoff point of −20.75 had 93.55% sensitivity and 66.67% specificity to detect significant CAD (P=.003, areas under the curve [AUC]=0.73). The average territorial strain cutoff point for significant left anterior descending (LAD) lesion was −15.4 with 77.78% sensitivity and 82.86% specificity (P=.0001, AUC=0.78) and for non‐LAD lesion was −16.9 with 82.93% sensitivity and 53.85% specificity (P=.0009, AUC=0.69). Two‐dimensional strain at peak stress showed better agreement than DSE as regard number of vessels affected (K=0.579 vs 0.107), LAD lesion detection (K=0.783 vs 0.438), and non‐LAD lesion detection (K=0.699 vs 0.233). Global longitudinal strain (GLS) at peak stress reduced DSE false positivity by 83%; the number of false‐positive patients was reduced from 18 patients to only three patients.ConclusionTwo‐dimensional strain at peak stress had an incremental value over DSE visual assessment/ wall‐motion score index (WMSI) in reducing false‐positive results of DSE. Two‐dimensional strain at peak stress had greater accuracy than DSE alone not only in detection of significant CAD but also in detection of number of vessels with significant lesion as well as CAD localization.
The effects of intransitive competition on coexistence
Authors: Gallien Laure , Zimmermann Niklaus E. , Levine Jonathan M. , Adler Peter B. 
Published: May 2017

AbstractCoexistence theory has been developed with an almost exclusive focus on interactions between two species, often ignoring more complex and indirect interactions, such as intransitive loops, that can emerge in competition networks. In fact, intransitive competition has typically been studied in isolation from other pairwise stabilising processes, and thus little is known about how intransitivity interacts with more traditional drivers of species coexistence such as niche partitioning. To integrate intransitivity into traditional coexistence theory, we developed a metric of growth rate when rare, , to identify and quantify the impact of intransitive competition against a backdrop of pairwise stabilising niche differences. Using this index with simulations of community dynamics, we demonstrate that intransitive loops can both stabilise or destabilise species coexistence, but the strength and importance of intransitive interactions are significantly affected by the length and the topology of these loops. We conclude by showing how can be used to evaluate effects of intransitivity in empirical studies. Our results emphasise the need to integrate complex mechanisms emerging from diverse interactions into our understanding of species coexistence.