bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Characteristics of Oleogel Prepared from Sunflower Oil with β‐Sitosterol and Stearic Acid
Authors: Yang Shu , Li Guode , Saleh Ahmed S. M. , Yang Hongli , Wang Na , Wang Peng , Yue Xiqing , Xiao Zhigang 
Published: August 2017

Abstractβ‐Sitosterol (Sit) and stearic acid (SA) were combined at varying ratios (w/w) and added to sunflower oil (SFO) at the concentration of 20 g/100 g oil for preparing edible fat‐like oleogel. The oleogel was characterized using an optical microscope, Fourier transform infrared spectroscopy (FTIR), X‐ray diffractometer (XRD), differential scanning calorimeter, and texture analyzer. The oil‐binding capacity, melting temperature, and firmness of the oleogel increased with the increase in the amount of SA in the gelator combination (Sit:SA, w/w). The microscopic analysis showed that the gel network formed based on the crystallization and self‐organization of gelator molecules, and both gelators showed an independent crystalline behavior in the oleogel. In addition, the FTIR spectra showed that the gel network formed via physical entanglements and was stabilized by non‐covalent interactions such as hydrogen bonding. Furthermore, XRD diffraction patterns indicated high lateral packing of molecular layers in oleogel prepared with the Sit and SA combination compared with oleogel prepared with a single gelator. On the other hand, for studying the effect of varying concentrations of gelator combinations, the Sit3:SA2 (w/w) combination was added to SFO at concentrations of 10, 15, 20, 25, and 30 g/100 g oil. Specific characteristics such as the oil‐binding capacity and firmness of the oleogel improved as the concentration of the gelator combination (Sit3:SA2) increased from 10 up to 30 g/100 g oil. Therefore, it can be concluded that the saturated fat alternative oleogel can be prepared from SFO with a specific Sit and SA combination ratio and concentration.
Efficacy and Tolerability of Delayed-release Dimethyl Fumarate in Black, Hispanic, and Asian Patients with Relapsing-Remitting Multiple Sclerosis: Post Hoc Integrated Analysis of DEFINE and CONFIRM
Authors: Fox Robert J. , Gold Ralf , Phillips J. Theodore , Okwuokenye Macaulay , Zhang Annie , Marantz Jing L. 
Published: August 2017

Abstract
Introduction
Clinical course and treatment response may vary according to race/ethnicity in multiple sclerosis (MS) patients. Delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) demonstrated significant efficacy and a favorable benefit–risk profile in relapsing-remitting MS (RRMS) patients in the 2-year phase III DEFINE/CONFIRM studies.

Methods
In this post hoc analysis of integrated data from DEFINE/CONFIRM, we assessed clinical efficacy and safety/tolerability in black, Hispanic, and Asian patients treated with DMF 240 mg twice daily (approved dosage) or placebo. Eligible patients were 18–55 years of age with an Expanded Disability Status Scale score of 0–5.0. In the integrated intention-to-treat population, 769 and 771 patients were treated with DMF or placebo, respectively, of whom 10 and 19 were black, 31 and 23 were Hispanic, and 66 and 70 were Asian.

Results
In the black, Hispanic, and Asian subgroups, DMF was associated with lower annualized relapse rates at 2 years compared with placebo [rate ratio (95% confidence interval (CI)), 0.05 (0.00–1.07); 0.31 (0.10–0.95); and 0.64 (0.30–1.34), respectively]. The percentage of black, Hispanic, and Asian patients with 12-week confirmed disability progression was lower with DMF (43%, 8%, and 20%, respectively) compared with placebo [57%, 30%, and 25%, respectively; hazard ratio (95% CI), 0.53 (0.02–1.39); 0.17 (0.00–0.60); and 0.71 (0.32–1.58), respectively]. The safety/tolerability profile of DMF was generally consistent with that in the overall population of DEFINE/CONFIRM. The incidence of adverse events leading to treatment discontinuation in black, Hispanic, and Asian patients was 2/10, 2/31, and 3/66, respectively, with DMF, and 2/19, 1/23, and 8/70, respectively, with placebo.

Conclusion
DMF may be an efficacious treatment with a favorable benefit–risk profile in black, Hispanic, and Asian patients with RRMS. Further clinical studies are needed to characterize differences in MS presentation and treatment outcomes across ethnic and racial groups.

Funding
Biogen.

Trial Registration
DEFINE: ClinicalTrials.gov identifier NCT00420212; CONFIRM ClinicalTrials.gov identifier NCT00451451.
Stress, attention deficit hyperactivity disorder (ADHD) symptoms and tobacco smoking: The i-Share study
Authors: Galéra C. , Salla J. , Montagni I. , Hanne-Poujade S. , Salamon R. , Grondin O. , Guichard E. , Bouvard M.P. , Tzourio C. , Michel G. 
Published: August 2017

AbstractBackground:The contribution of mental health to the risk of smoking is increasingly acknowledged but still insufficiently studied during the key period of student life. In particular, the simultaneous action of stress and Attention Deficit Hyperactivity Disorder (ADHD) symptoms on the risk of smoking remains poorly understood.Aims:To assess the effects of stress and ADHD symptoms on tobacco smoking.Method:Multivariate modeling was conducted on the French i-Share study (n = 8110, median age 20.3 years, 74.8% females, 32.9% regular/occasional smokers) to evaluate the associations between stress, ADHD symptoms and tobacco smoking, adjusting for potential family/socio-demographic confounders.Results:Students with high levels of stress were more likely to smoke > 10 cigarettes/day (adjusted odds ratio (aOR): 1.48, 95% CI: 1.12–1.96) than those with low levels of stress. Students with high levels of ADHD symptoms were more likely to smoke > 10 cigarettes/day (aOR: 2.08, 95% CI: 1.58–2.75) than those with low levels of ADHD symptoms.Conclusions:Stress and ADHD contribute independently to the risk of smoking. Interventions targeting each condition are likely to reduce the burden of tobacco use in students.
Client personal recovery and recovery orientation of an Irish suicide intervention charity
Authors: Conway C. , Surgenor P. W. G. , Thekiso T. B. , Moore A. , Campion A. , Tormey A. , Rush G. 
Published: August 2017

BackgroundRecovery is a key goal for individuals, and services’ recovery orientation can facilitate this process. The independent mental health sector is increasingly important in Ireland, particularly in counselling and suicide prevention. We aimed to evaluate Pieta House as a recovery-oriented service through clients’ self-rated recovery; and clients’ and therapists’ evaluation of the service.MethodsClients completing therapy over a 3-month period were invited to complete the Recovery Assessment Scale (RAS) and the Recovery Self Assessment-Revised (RSA-R). Therapists completed the RSA-R staff version.ResultsResponse rate was 36.7% for clients (n=88), 98% for therapists (n=49). Personal recovery was endorsed by 73.8% of clients, with highest agreement for factors ‘Willingness to Ask for Help’ (84.5%), and ‘Reliance on Others’ (82.1%). A smaller number agreed with factors ‘Personal Confidence and Hope’ (61.3%) and ‘No Domination by Symptoms’ (66.6%). Clients’ and therapists’ evaluation of the service showed high levels of agreement with factors of ‘Choice’ (90.9% clients, 100% therapists); ‘Life Goals’ (84.1% clients, 98% therapists) and ‘Individually Tailored Services’ (80.6% clients, 79.6% therapists). Client involvement in service management had the lowest level of agreement (36.4% clients, 30.6% therapists). Clients’ self-rated recovery correlated with their rating of the service (correlation value 0.993,p=0.01).ConclusionsClients’ self-rated recovery and the recovery orientation of Pieta House were rated highly, with areas for improvement in service user involvement, peer support and advocacy. The correlation of personal recovery and recovery orientation of the service may merit further study.
A ~6000 yr diatom record of mid- to late Holocene fluctuations in the level of Lago Wiñaymarca, Lake Titicaca (Peru/Bolivia)
Authors: Weide D. Marie , Fritz Sherilyn C. , Hastorf Christine A. , Bruno Maria C. , Baker Paul A. , Guedron Stephane , Salenbien Wout 
Published: August 2017

AbstractA multidecadal-scale lake-level reconstruction for Lago Wiñaymarca, the southern basin of Lake Titicaca, has been generated from diatom species abundance data. These data suggest that ~6500 cal yr BP Lago Wiñaymarca was dry, as indicated by a sediment unconformity. At ~4400 cal yr BP, the basin began to fill, as indicated by the dominance of shallow epiphytic species. It remained somewhat saline with extensive wetlands and abundant aquatic plants until ~3800 cal yr BP, when epiphytic species were replaced by planktic saline-indifferent species, suggesting a saline shallow lake. Wiñaymarca remained a relatively shallow lake that fluctuated on a multidecadal scale until ~1250 cal yr BP, when freshwater planktic species increased, suggesting a rise in lake level with a concomitant decrease in salinity. The lake became gradually fresher, dominated by deep, freshwater species from ~850 cal yr BP. By ~80 cal yr BP, saline-tolerant species were rare, and the lake was dominated by freshwater planktic diatoms, resembling the fresh and deep lake of today. These results reveal a more dynamic and chronologically specific record of lake-level fluctuations and associated ecological conditions that provide important new data for paleoclimatologists and archaeologists, to better understand human-environmental dynamics during the mid- to late Holocene.
Early Jurassic adakitic rocks in the southern Lhasa sub-terrane, southern Tibet: petrogenesis and geodynamic implications
Authors: SHUI XINFANG , HE ZHENYU , KLEMD REINER , ZHANG ZEMING , LU TIANYU , YAN LILI 
Published: August 2017

AbstractCretaceous–Miocene adakitic rocks in the southern Lhasa sub-terrane have been intensively investigated, while possible Early Jurassic adakitic rocks in this area have been largely neglected. Petrological and geochemical studies revealed adakitic affinities of an Early Jurassic quartz diorite intrusion with mafic enclaves and three tonalite bodies from the Jiacha area in the southern Lhasa sub-terrane. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) zircon U–Pb dating suggests crystallization ages of 199–179 Ma for these rocks. Both quartz diorites and tonalites have typical adakitic geochemical characteristics such as high Al2O3 (15.14–18.22 wt.%) and Sr (363–530 ppm) contents, low Y (4.46–15.9 ppm) and Yb (0.51–1.74 ppm) contents and high Sr/Y ratios of 27–106. The adakitic quartz diorites are further characterized by high MgO (2.63–3.46 wt.%), Mg# (48–54) and εHf(t) (6.6–13.4) values, which were probably produced by partial melting of a subducted oceanic slab with a mantle contribution. The adakitic tonalites have very low abundances of compatible elements and relatively low εHf(t) values (3.5–10.3), and are interpreted to have formed by partial melting of Neoproterozoic mafic lower crust. Upwelling asthenosphere, triggered by rollback of the subducting Bangong–Nujiang (Meso-Tethys) oceanic plate, provided the necessary heat for slab and lower crust melting, resulting in the geochemical diversity of the coexisting felsic intrusive rocks. Contrary to other models, this study further demonstrates that the Bangong–Nujiang oceanic plate was subducted southward beneath the Lhasa terrane during the Early Jurassic.
Testing the early Late Ordovician cool-water hypothesis with oxygen isotopes from conodont apatite
Authors: QUINTON PAGE C. , LAW STACEY , MACLEOD KENNETH G. , HERRMANN ACHIM D. , HAYNES JOHN T. , LESLIE STEPHEN A. 
Published: August 2017

AbstractLatest Sandbian to early Katian sequences across Laurentia's epicontinental sea exhibit a transition from lithologies characterized as ‘warm-water’ carbonates to those characterized as ‘cool-water'carbonates. This shift occurs across the regionally recognized M4/M5 sequence stratigraphic boundary and has been attributed to climatic cooling and glaciation, basin reorganization and upwelling of open ocean water, and/or increased water turbidity and terrigenous input associated with the Taconic tectophase. Documentation of oxygen isotopic trends across the M4/M5 and through bracketing strata provides a potential means of distinguishing among these alternative scenarios; however, oxygen isotopic records generated to date have failed to settle the debate. This lack of resolution is because δ18O records are open to multiple interpretations and potentially confounding factors related to local environmental conditions have not been tested by examining the critical interval in multiple areas and different depositional settings. To begin to address this shortcoming, we present new species-specific and mixed assemblage conodont δ18O values in samples spanning the M4/M5 boundary from the Upper Mississippi Valley, Alabama, and Virginia. The new results are combined with previous studies, providing a record of δ18O variability across SE Laurentia. The combined dataset allows us to test for regional trends at a resolution not previously available. Our results document a ~1.5‰ decrease in values across Laurentia instead of increasing δ18O values across the M4/M5 as predicted in various ‘cool-water’ scenarios. In short, these results do not support a shift to ‘cool-water’ conditions as an explanation for changes in early Katian carbonates across the M4/M5.
Colonial State Formation Without Integration: Tax Capacity and Labour Regimes in Portuguese Mozambique (1890s–1970s)
Authors: Alexopoulou Kleoniki , Juif Dácil 
Published: August 2017

AbstractSamir Amin (1972) divided the African continent into three “macro-regions of colonial influence” with distinct socio-economic systems and labour practices: Africa of the colonial trade or peasant economy, Africa of the concession-owning companies, and Africa of the labour reserves. We argue that Mozambique encompassed all three different “macro-regions” in a single colony. We reconstruct government revenue (direct/indirect taxes) raised at a district level between 1930 and 1973 and find persisting differences in the “tax capacity” of the three regions throughout the colonial period. The tax systems, we claim, developed in response to existing local geographic and economic conditions, particularly to labour practices. Portuguese colonial rule adapted to and promoted labour practices such as migration and forced labour to maximize revenue. The extent to which the lack of integration played a role in the post-colonial state and fiscal failure should be studied further.
Parallels with the hate speech debate: the pros and cons of criminalising harmful securitising requests
Authors: Floyd Rita 
Published: August 2017

AbstractThis article argues that public expressions of Islamophobia are best understood assecuritising requests(that is, calls on powerful figures/bodies to treat an issue in security mode so that extraordinary measures can be used to combat it), especially in those cases where Muslims are feared and disliked because of the perception that Islamic people are prone to terrorism. This article argues that harmful and derogatory securitising requests targeting racial, ethnic, or religious minorities are on par with hate speech and it highlights the fact that many contemporary societies are now seeking legal protections against such security speech (expressed most notably in the desire to ban Islamophobia). It is from this perspective that this article poses an important research question: With a view to protecting those adversely affected, are legal protections against harmful and offensive securitising requests justified? The research question can be answered by drawing parallels to the existing hate speech debate in legal and political theory. The research reveals that, although the case against legal protections of harmful and defamatory security speech is ultimately more convincing, security speech alone can be so damaging that it should be informed by a number of ethical considerations. This article goes on to suggest three criteria for governing the ethics of requesting securitisation. As such this article fills a lacuna in the ‘positive/negative debate’ on the ethics of security that has engaged with securitisation, but that has failed to consider the ethics of speaking security.
Purinergic modulation of frog electroretinographic responses: The role of the ionotropic receptor P2X7
Authors: KUPENOVA PETIA , POPOVA ELKA , VITANOVA LILIYA 
Published: August 2017

AbstractThe contribution of the purinergic receptors P2X7 (P2X7Rs) to the electroretinographic (ERG) responses was studied by testing the effects of the selective P2X7R antagonist A438079 and the selective P2X7R agonist Bz-ATP on the electroretinograms obtained in perfused frog (Rana ridibunda) eyecup preparations under a variety of stimulation conditions. The P2X7R blockade by 200 µM A438079 diminished the amplitude of the photoreceptor components: the a-wave and the pharmacologically isolated mass receptor potential. In the pure rod-driven and pure cone-driven responses, the amplitude of the postreceptoral ON (b-wave) and OFF (d-wave) components was also diminished. The OFF responses were affected to a greater extent compared to the ON responses. In the mixed rod- and cone-driven responses, obtained in the mesopic intensity range, the b-wave amplitude was increased, while the d-wave amplitude was decreased. The amplitude of the oscillatory potentials was diminished. The relative amplitude changes produced by the P2X7R blockade were greater in the dark-adapted compared to the light-adapted eyes. The application of 100 µM Bz-ATP produced small effects opposite to those of the antagonist, while a prolonged (>20 min) treatment with 1 mM Bz-ATP resulted in a significant amplitude reduction or even abolishment of b- and d-waves. Our results show that endogenous ATP through its P2X7Rs exerts significant, mostly potentiating effects on the ERG photoreceptor and postreceptoral responses. There is a clear ON/OFF asymmetry of the effects on the ERG postreceptoral responses favoring OFF responses: they are always strongly potentiated, while the ON responses are either less potentiated (in the rod-driven and most of the cone-driven responses) or even inhibited (in the mixed rod- and cone-driven responses). The overstimulation of P2X7Rs can produce acute pathological changes, that is, a decrease or abolishment of the ERG responses.
Expectations and limitations of ovarian tissue transplantation
Authors: Donfack N.J. , Alves K.A. , Araújo V.R. , Cordova A. , Figueiredo J.R. , Smitz J. , Rodrigues A.P.R. 
Published: August 2017

SummaryConstant progress in the diagnosis and treatment of cancer disease has increased the number and prognosis of cancer survivors. However, the toxic effects of chemotherapy and radiotherapy on ovarian function have resulted in premature ovarian failure. Patients are, therefore, still expecting methods to be developed to preserve their fertility successfully. Several potential options are available to preserve fertility in patients who face premature ovarian failure, including immature or mature oocyte and embryo cryopreservation. However, for children or prepubertal women needing immediate chemotherapy, cryopreservation of ovarian tissue is the only alternative. The ultimate aim of this strategy is to implant ovarian tissue into the pelvic cavity (orthotopic site) or in a heterotopic site once oncological treatment is completed and the patient is disease free. Transplantation of ovarian tissue with sufficiently large numbers of follicles could potentially restore endocrine function and allow multiple cycles for conception. However, the success of ovarian tissue transplantation still has multiple challenges, such as the low number of follicles in the graft that may affect their longevity as well as the survival of the tissue during ex vivo processing and subsequent transplantation. Therefore, this review aims to summarize the achievements of ovary grafting and the potential techniques that have been developed to improve ovarian graft survival.
Comparative Environmental Federalism: Subsidiarity and Central Regulation in the United States and China
Authors: Zhao Huiyu , Percival Robert 
Published: August 2017

AbstractThe proper division of responsibility for environmental protection between national and state governments has long been the subject of fierce debate. During the 1970s the United States Congress decided to shift the most important environmental responsibilities from state governments to the federal government. The main reason for this decision was to prevent a ‘race to the bottom’ in that states competing for industries could otherwise be lax in implementing and enforcing federal environmental standards. Yet, some scholars have argued that there could just as easily be a ‘race to the top’ among states as they compete to attract people and businesses concerned with environmental protection. China, in turn, is plagued with severe air and water pollution and soil contamination, which is attributed largely to ineffective enforcement of its national environmental laws. This article investigates whether China’s experience confirms the race-to-the-bottom theory. It demonstrates that devolution of responsibility for environmental protection to lower levels of government tends to result in lax implementation and enforcement of national environmental laws, particularly where national governments also create strong incentives for economic growth. It concludes that China’s highly devolved system of environmental governance is consistent with this theory, even if it does not provide conclusive evidence of its correctness.
Zhamanshin astrobleme provides evidence for carbonaceous chondrite and post-impact exchange between ejecta and Earth’s atmosphere
Authors: Magna Tomáš , Žák Karel , Pack Andreas , Moynier Frédéric , Mougel Bérengère , Peters Stefan , Skála Roman , Jonášová Šárka , Mizera Jiří , Řanda Zdeněk 
Published: August 2017

AbstractChemical fingerprints of impacts are usually compromised by extreme conditions in the impact plume, and the contribution of projectile matter to impactites does not often exceed a fraction of per cent. Here we use chromium and oxygen isotopes to identify the impactor and impact-plume processes for Zhamanshin astrobleme, Kazakhstan. ε54Cr values up to 1.54 in irghizites, part of the fallback ejecta, represent the54Cr-rich extremity of the Solar System range and suggest a CI-like chondrite impactor. Δ17O values as low as −0.22‰ in irghizites, however, are incompatible with a CI-like impactor. We suggest that the observed17O depletion in irghizites relative to the terrestrial range is caused by partial isotope exchange with atmospheric oxygen (Δ17O = −0.47‰) following material ejection. In contrast, combined Δ17O–ε54Cr data for central European tektites (distal ejecta) fall into the terrestrial range and neither impactor fingerprint nor oxygen isotope exchange with the atmosphere are indicated.