bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal diagnosis of susceptibility loci for neurodevelopmental disorders – genetic counseling and pregnancy outcome in 57 cases
Authors: Govaerts Lutgarde , Srebniak Malgorzata , Diderich Karin , Joosten Marieke , Riedijk Sam , Knapen Maarten , Go Attie , Papatsonis Dimitri , de Graaf Katja , Toolenaar Toon , van der Steen Sanne , Huijbregts Gido , Knijnenburg Jeroen , de Vries Femke , Van Opstal Diane , Galjaard Robert‐Jan 
Published: December 2016

AbstractBackgroundWhole genome array testing not only provides an increased diagnostic yield of pathogenic causative findings, but it may also reveal so called susceptibility loci (SL) for neurodevelopmental disorders. The goal of this study was to evaluate the pregnancy outcomes in SL cases and to establish a protocol for pregnancy management, follow‐up and additional investigations.MethodsFifty seven cases were evaluated: 34 with and 23 without ultrasound anomalies at referral. Each pregnant couple received pretest counseling and extensive posttest genetic counseling.ResultsAfter diagnosis of SL, parental testing and an additional ultrasound examination were offered. The severity of the ultrasound anomalies and not the diagnosis of SL was the most important factor contributing to the decision on pregnancy continuation. In the majority of cases with milder or no ultrasound anomalies, the pregnancy was continued and a normal outcome after birth was observed.ConclusionsThe diagnosis of a SL did not seem to be a reason for termination of pregnancy. Most patients were able to cope with the uncertainty and were interested in both prenatal and postnatal actionability of SL. Long‐term follow‐up is crucial to assess the actual risks for neurodevelopmental disorders, especially in families with unremarkable history. © 2016 John Wiley & Sons, Ltd.
SGLT2 Inhibitors: A Systematic Review of Diabetic Ketoacidosis and Related Risk Factors in the Primary Literature
Authors: Burke Kelly R. , Schumacher Christine A. , Harpe Spencer E. 
Published: December 2016

Study ObjectiveCurrently only minimal information is available regarding risk factors for the development of sodium glucose cotransporter‐2 inhibitor (SGLT2i)‐related diabetic ketoacidosis (DKA). We aim to identify individual patient characteristics associated with cases of SGLT2i‐related DKA to better describe potential risk factors.DesignSystematic review of primary literature.PatientsThirty‐four case reports of patients with type 1 and type 2 diabetes mellitus who developed DKA while receiving an SGLT2i.Methods and Main ResultsThis systematic review investigated the relationship between SGLT2i and DKA in patients with diabetes. The existing literature was reviewed with a primary outcome to identify patient‐specific factors contributing to the incidence of ketoacidosis in patients with diabetes who were treated with a SGLT2i. Numerous databases were searched to identify appropriate primary literature. Search terms included canagliflozin, dapagliflozin, empagliflozin, SGLT2, sodium glucose cotransporter‐2 inhibitor, diabetic ketoacidosis, ketoacidosis, metabolic acidosis, and acidosis. Primary literature was analyzed via descriptive statistics. Thirty‐four individual case reports were identified via the primary literature search. Two‐thirds (25 cases) involved patients with a diagnosis of type 2 diabetes mellitus (T2DM). The average blood glucose on presentation for SGLT2i‐induced DKA was 265.6 ± 140.7 mg/dl (14.7 ± 7.8 mmol/L), with common symptoms including nausea, vomiting, and abdominal pain. Common precipitating factors included patients who were diagnosed with T2DM and were subsequently found to have latent autoimmune diabetes of adulthood, patients who had recently undergone major surgery, or patients who had decreased or discontinued insulin. No cases were fatal.ConclusionIn this review, episodes of DKA with SGLT2i use were characterized by lower blood glucose levels and were often caused by a precipitating factor. Understanding precipitating factors for SGLT2i‐related DKA may help providers better identify patients at risk for development of DKA.
Tri‐orthogonal polarization diversity reception for non‐geosynchronous satellite orbit ionospheric channels
Authors: Lawrence Nicholas P. , Hansen Hedley J. , Abbott Derek 
Published: December 2016

SummaryElectromagnetic signals propagating through the ionosphere are subject to path delay and the depolarizing effect of Faraday rotation. These are both dependent on global position and link geometry, which constantly vary for satellites in non‐geosynchronous orbits. These effects introduce performance error and reduce range resolution of remote sensing polarimetric measurements. Communication with ground receivers may be severely degraded by these effects. In this paper, a tri‐orthogonal approach at the receiver is introduced to enhance performance of conventional polarization diverse receive schemes. Performance is measured through a capacity metric. The work presented forms part of a large‐field‐of‐view, non‐geosynchronous satellite model exploiting tri‐orthogonal receive polarimetry as a means to enhancing link performance in a field‐of‐view. Copyright © 2016 John Wiley & Sons, Ltd.
Efficient certificate‐based encryption schemes without pairing
Authors: Le Minh‐Ha , Kim Intae , Hwang Seong Oun 
Published: December 2016

AbstractRecently, a lot of researches focused on identity‐based encryption (IBE). The advantage of this scheme is that it can reduce the cost of the public key infrastructure by simplifying certificate management. Although IBE has its own innovations, one of its weaknesses is the key escrow problem. That is, the private key generator in IBE knows decryption keys for all identities and consequently can decrypt any ciphertexts. The certificate‐based encryption (CBE) scheme proposed in EUROCRYPT 2003 provides a solution for the key escrow problem by allowing the certification authority to possess a partial decryption key that comprises the full decryption key together with the user‐generated private key. In this paper, we propose new CBE schemes without pairing and prove them to be Indistinguishability under Chosen Ciphertext Attack secure in the random oracle model based on the hardness of the computational Diffie–Hellman problem. When compared with other CBE schemes, our schemes are significantly efficient in terms of performance, which makes our schemes suitable for computation‐limited node (e.g., sensor, wearable device) networks. Copyright © 2016 John Wiley & Sons, Ltd.
Effect of Remote Ischaemic Preconditioning on Liver Injury in Patients Undergoing Major Hepatectomy for Colorectal Liver Metastasis: A Pilot Randomised Controlled Feasibility Trial
Authors: Kanoria Sanjeev , Robertson Francis P. , Mehta Naimish N. , Fusai Giuseppe , Sharma Dinesh , Davidson Brian R. 
Published: December 2016

AbstractBackgroundLiver resection produces excellent long‐term survival for patients with colorectal liver metastases but is associated with significant morbidity and mortality from ischaemia reperfusion injury (IRI). Remote ischaemic preconditioning (RIPC) can reduce the effect of IRI. This pilot randomised controlled trial evaluated RIPC in patients undergoing major hepatectomy at the Royal Free Hospital, London.MethodsSixteen patients were randomised to RIPC or sham control. RIPC was induced through three 10‐min cycles of alternate ischaemia and reperfusion to the leg. At baseline and immediately post‐resection, transaminases and indocyanine green (ICG) clearance were measured.FindingsThe RIPC group had lower ALT and AST levels immediately post‐resection (ALT: 43% lower 497 ± 165 vs 889 ± 170 IU/L; p = 0.019 AST: 54% lower 408 ± 166 vs 836 ± 167 IU/L; p = 0.001) and at 24 h (ALT: 41% lower 412 ± 144 vs 698 ± 137 IU/L; p = 0.026 AST: 50% lower 316 ± 116 vs 668 ± 115 IU/L; p = 0.02). ICG clearance was reduced in controls versus RIPC immediately after resection (ICG‐PDR: 11.1 ± 1.1 vs 16.5 ± 1.4%/min; p = 0.035).ConclusionsThis pilot study shows that RIPC has potential to reduce liver injury following hepatectomy justifying a prospective RCT powered to demonstrate clinical benefits.
A case of tetanus secondary to an odontogenic infection
Authors: Darraj Majid , Stone James , Keynan Yoav , Thompson Kristjan , Snider Carolyn 
Published: December 2016

Abstract
Tetanus is a life-threatening clinical syndrome that commonly presents with
muscular spasms, rigidity, and autonomic instability. It is considered rare in
industrialized countries, and tetanus occurring secondary to dental abscesses,
procedures, or infections has been infrequently reported. We describe the case of
a patient inadequately immunized for tetanus, who presented to the emergency
department with muscular spasms, rigidity, and autonomic instability in the
setting of an odontogenic infection. A clinical diagnosis of tetanus was made and
subsequently managed successfully.
Factors influencing the intentions of nurses and respiratory therapists to use automated external defibrillators during in-hospital cardiac arrest: a qualitative interview study
Authors: Andrews Jessica , Vaillancourt Christian , Jensen Jan , Kasaboski Ann , Charette Manya , Clement Catherine M. , Brehaut Jamie C. , Osmond Martin H. , Wells George A. , Stiell Ian G. , Grimshaw Jeremy 
Published: December 2016

AbstractObjectivesNurses and respiratory therapists are seldom allowed to use automated external defibrillators (AED) during in-hospital cardiac arrest. This can result in significant time delays before defibrillation occurs and lower survival for cardiac arrest victims. We sought to identify barriers and facilitators to AED use by nurses and respiratory therapists.MethodsWe conducted semi-structured qualitative interviews with a purposeful sample of nurses and respiratory therapists. We developed the interview guide based on the constructs of the theory of planned behaviour, which elicits salient attitudes, social influences, and control beliefs potentially influencing the intent to use an AED. Interviews were recorded, transcribed verbatim, and analysed until achieving data saturation. Two independent reviewers performed inductive analyses to identify emerging categories and themes, and ranked them by frequency of the number of participants stating the topic.ResultsDemographics for the 24 interviewees include mean age 40.5, 79.2% female, 87.5% performed cardiopulmonary resuscitation (CPR), 29.2% defibrillated a patient. Identified attitudes pertained to the timeliness of defibrillation, patient survival, simplicity of AED use, accuracy of rhythm recognition, and harm to self or others. Social influences consisted of physician and hospital administration support of AED use. Control beliefs included training on AED use, policy allowing AED use, familiarity with AED, and task burden during resuscitation.ConclusionsMost nurses and respiratory therapists intended to use an AED if permitted to do so by a medical directive. Successful implementation would require educational initiatives focusing on safety and efficacy of AEDs, support from physicians and hospital administrators, and additional training on AED use.
First Successful Pre-Distribution of Stable Iodine Tablets Under Japan’s New Policy After the Fukushima Daiichi Nuclear Accident
Authors: Ojino Mayo , Yoshida Sumito , Nagata Takashi , Ishii Masami , Akashi Makoto 
Published: December 2016

AbstractStable iodine tablets are effective in reducing internal exposure to radioactive iodine, which poses a risk for thyroid cancer and other conditions. After the Fukushima Daiichi nuclear power plant accident, the Japanese government shifted its policy on stable iodine tablet distribution from “after-the-fact” to “before-the-fact” and instructed local governments to pre-distribute stable iodine tablets to residents living within a 5-km radius of nuclear facilities. The nation’s first pre-distribution of stable iodine tablets was carried out in June and July of 2014 in Kagoshima Prefecture. Health surveys were conducted so that the medication would not be handed out to people with the possibility of side effects. Of the 4715 inhabitants in the area, 132 were found to require a physician’s judgment, mostly to exclude risks of side effects. This was considered important to prevent the misuse of the tablets in the event of a disaster. The importance of collective and individualized risk communication between physicians and inhabitants at the community health level was apparent through this study. Involvement of physicians through the regional Sendai City Medical Association was an important component of the pre-distribution. Physicians of the Sendai City Medical Association were successfully educated by using the Guidebook on Distributing and Administering Stable Iodine Tablets prepared by the Japan Medical Association and Japan Medical Association Research Institute with the collaboration of the National Institute of Radiological Sciences and the Japanese government. Thus, the physicians managed to make decisions on the dispensing of stable iodine tablets according to the health conditions of the inhabitants. All physicians nationwide should be provided continuing medical education on stable iodine tablets. (Disaster Med Public Health Preparedness. 2017;11:365–369)
Oxidative stress in major depressive and anxiety disorders, and the association with antidepressant use; results from a large adult cohort
Authors: Black C. N. , Bot M. , Scheffer P. G. , Penninx B. W. J. H. 
Published: December 2016

BackgroundOxidative stress has been implicated in the pathophysiology of major depressive disorder (MDD) and anxiety disorders and may be influenced by antidepressant use. This study investigated the association of oxidative stress, measured by plasma levels of F2-isoprostanes and 8-hydroxy-2′-deoxyguanosine (8-OHdG) reflecting oxidative lipid and DNA damage respectively, with MDD, anxiety disorders and antidepressant use in a large cohort.MethodData was derived from the Netherlands Study of Depression and Anxiety including patients with current (N = 1619) or remitted (N = 610) MDD and/or anxiety disorder(s) (of which N = 704 antidepressant users) and 612 controls. Diagnoses were established with the Composite International Diagnostic Interview. Plasma 8-OHdG and F2-isoprostanes were measured using LC-MS/MS. ANCOVA was performed adjusted for sampling, sociodemographic, health and lifestyle variables.ResultsF2-isoprostanes did not differ between controls and patients, or by antidepressant use. Patients with current disorders had lower 8-OHdG (mean 42.1 pmol/l, 95% CI 40.4–43.8) compared to controls (45.0 pmol/l, 95% CI 42.9–47.2; p < 0.001) after adjustment for sampling, sociodemographics and lifestyle, but these differences disappeared after further adjustment for antidepressant use (p = 0.562). Antidepressant users had lower 8-OHdG levels (38.2 pmol/l, 95% CI 36.5–39.9) compared to controls (44.9 pmol/l, 95% CI 43.2–46.6; Cohen's d = 0.21, p < 0.001). Results for 8-OHdG were comparable across disorders (MDD and/or anxiety disorders), and all antidepressant types (SSRIs, TCAs, other antidepressants).ConclusionContrary to previous findings this large-scale study found no increased oxidative stress in MDD and anxiety disorders. Antidepressant use was associated with lower oxidative DNA damage, suggesting antidepressants may have antioxidant effects.
A meta-analysis of acute use of alcohol and the risk of suicide attempt
Authors: Borges G. , Bagge C. L. , Cherpitel C. J. , Conner K. R. , Orozco R. , Rossow I. 
Published: December 2016

BackgroundNo review has used a meta-analytic approach to estimate common odds ratios (ORs) for the effect of acute use of alcohol (AUA) on suicide attempts. We aim to report the results of the first meta-analysis of controlled epidemiological studies on AUA and suicide attempt.MethodThe English-language literature on Medline, PsycINFO and Google Scholar was searched for original articles and critical review on AUA and suicide attempt (period 1996–2015). Studies had to report an OR estimate for this association. Common ORs and 95% confidence intervals (CIs) from random effects in meta-analyses for any AUA and two levels of alcohol use on suicide attempt were calculated.ResultsIn all, seven studies provided OR estimates for the likelihood of suicide attempt by AUA, compared with those who did not drink alcohol. Studies used case–control (n3) and case–crossover designs (n4). Meta-analysis revealed a common OR of 6.97 (95% CI 4.77–10.17) for any AUA. Using four studies, ‘low levels of acute drinking’ resulted in an OR of 2.71 (95% CI 1.56–4.71) and ‘high levels’ had an OR of 37.18 (95% CI 17.38–79.53).ConclusionsAUA is associated with increased likelihood of a suicide attempt, particularly at high doses. Such data should be incorporated into estimates of the burden of disease associated with alcohol use, which are currently limited by a consideration of only alcohol's chronic effects. Future research should focus on the mechanisms through which AUA confers risk for attempt.
The fourth face of legitimacy: Constituent power and the constitutional legitimacy of international institutions
Authors: Oates John G. 
Published: December 2016

AbstractScholars of international organisation commonly differentiate among three dimensions when studying the legitimacy of international institutions: input, throughput, and output legitimacy. I argue that the study of global governance needs to consider a fourth ‘face’ of legitimacy: constitutional legitimacy. This dimension addresses the normative and practical questions related to the constitutive justification for an institutional order – such as in whose name it is founded, whose interests it should serve, and how authority should be distributed within that institutional order. These questions are distinct from the procedural features of institutions emphasised by other dimensions and concern the constituent power that should ground the authority of governance institutions. In this article, I develop this fourth dimension of legitimacy, explore its varied expressions in world politics, and show how it has implications for the constitutional structure of global governance arrangements. I argue that different representations of constituent power shape the legitimacy of different authority relations within international institutions and illustrate these claims with an analysis of the politics of legitimacy in three cases: the ongoing effort to reform the UN Security Council, the negotiations over the founding of the International Criminal Court, and the debates over the Responsibility to Protect at the UN.
Feed restriction and insulin-like growth factor-I (IGF-I) affect the oocyte maturation in matrinxãBrycon amazonicus
Authors: Montrezor Luís Henrique , Urbinati Elisabeth Criscuolo 
Published: December 2016

SummaryThe feeding and nutrition of breeders are crucial aspects in the reproductive process. During the maturation period, metabolic changes occur aiming at mobilizing energy for growth and follicular development. The involvement of IGF-1 in metabolic and reproductive events is important. The aim of this work was to evaluate if alternate feed restriction and re-feeding have permissive effects onin vitroactions of IGF-1 on oocytes development of matrinxã.In vivoexperiments were performed during vitellogenesis period. Females (n= 60) were fed with a commercial feed (2% of biomass) and they were divided into two treatments: fish receiving food daily (control – fed), and fish submitted to cycles of 3 days of feed restriction and 2 days of re-feeding (no-fed group). For thein vitroexperiments, oocytes (n= 20) were obtained from the ovaries removed at the end of thein vivoexperiment and were divided into four groups: fed –IGF-1; fed +IGF-1; no-fed –IGF-1 and no-fed +IGF-1. Fish under restriction had lower body weights, decreased plasma glucose, increased triglycerides levels, and their final maturation and mature oocyte were reduced and the atresic ones were in higher number. Moreover, IGF-1,in vitro, increased the percentage of mature oocytes in fed females and decreased the atresic ones. In no-fed females, IGF-1 increased the final maturation and mature oocytes and reduced the atresic ones. This study demonstrates the importance of the feeding management of female breeders of matrinxã during the vitellogenesis period.
A New Solution of Non-integrated Correlative Light and Electron Microscopy Based on High-vacuum Optical Platform
Authors: Li Shuoguo , Ji Gang , Huang Xiaojun , Sun Lei , Zhang Jianguo , Xu Wei , Sun Fei 
Published: December 2016

Abstract
Correlative light and electron microscopy (CLEM) offers a means of guiding the search for the unique or rare events by fluorescence microscopy (FM) and allows electron microscopy (EM) to zoom in on them for subsequent EM examination in three-dimensions (3D) and with nanometer-scale resolution. FM visualizes the localization of specific antigens by using fluorescent tags or proteins in a large field-of-view to study their cellular function, whereas EM provides the high level of resolution for complex structures. And cryo CLEM combines the advantages of maintaining structural preservation in a near-native state throughout the entire imaging process and by avoiding potentially harmful pre-treatments, such as chemical fixation, dehydration and staining with heavy metals. Besides for frozen-hydrated biological samples, CLEM combines the advantages of a close-to-life preservation of biological materials by keeping them embedded in vitreous ice throughout the entire imaging process and the frozen-hydrated condition is very suitable to maintain fluorescent signals. In recent years, many new instruments and software which intended to optimize the workflow and to obtain better experimental results of CLEM have been presented or even commoditized. While, the specimen damage during transfer from FM to EM and the resolution of CLEM were still need to be improved.
Here we set up a High-vacuum Optical Platform to develop CLEM imaging technology (HOPE), which was designed to realize high-vacuum optical ( fluorescent) imaging for cryo-sample on EM cryo-holder (e.g. Gatan 626). A non-integrated high-vacuum cryo-optical stage, which adapted to the EM cryo holder, was fixed on epi-fluorescence microscope (or super-resolution microscope) to obtain fluorescent images. And then the EM cryo holder would be transferred to EM for collection of EM data. This protocol was aimed to minimize the specimen damage during transfer from FM to EM and it was versatile to expend to different types of light microscopy or electron microscopy. Our HOPE had already passed correlative imaging test, and the results showed that it was convenient and effective.
The long-term mental health risk associated with non-heterosexual orientation
Authors: Burns R. A. , Butterworth P. , Jorm A. F. 
Published: December 2016

Aims.Findings that describe the mental health risk associated with non-heterosexual orientation in young and middle-aged adults are from cross-sectional designs or fail to discriminate homosexual and bisexual orientations. This study examines the mental health risk of homosexual and bisexual orientation over an 8-year period.Methods.Participants were from the age-cohort study, the Personality and Total Health Through Life Project, were observed twice every 4 years, and aged 20–24 (n = 2353) and 40–44 (n = 2499) at baseline.Results.Homosexual orientation was unrelated to long-term depression risk. Risk for anxiety and depression associated with homosexual and bisexual orientations, respectively, were attenuated in fully-adjusted models. Bisexual orientation risk associated with anxiety was partially attenuated in fully-adjusted models.Conclusions.Non-heterosexual orientation was not a major risk factor for long-term mental health outcomes. Instead, those with a non-heterosexual orientation were more likely to experience other mental health risk factors, which explain most of the risk observed amongst those with a non-heterosexual orientation.