bluuebunny/crossref_metadata_2025_split huggingface dataset:
PREVALENSI DEPRESI DAN GAMBARAN STRESSOR PSIKOLOSOSIAL PADA REMAJA SEKOLAH MENENGAH UMUM DI WILAYAH KOTAMADYA MALANG
Authors: Asmika Asmika , Harijanto Harijanto , Handayani Nina 
Published: January 2017

During the mental development process, the adolescent will be exposed tonumerous events that might act asÂ psychosocial stressors. These stressors might contribute to the prevalence of depression in adolescent. ThisÂ study aimed to determine the prevalence of depression description of psychosocial stressor, and theÂ relationship between psychosocial stressors and depression in adolescent. A cross sectional descriptiveÂ analytic study was conducted using 458 particiapants from three representative Senior High Schools inÂ Malang district. The depression level was measured Â using Beck Depression Inventory while Holmes andÂ Rahe Stress Scale for Youth was used to mesure the Â level of psychosocial stressor. It was found thatÂ prevalence of depression were as follows 32,5% of respondents with mild depression; 28,2% with moderateÂ depression; and the remaining 11,1% withsevere depression. Of all particiapants, 59,6% experience a highÂ level stressor, while the other 40,4% have low level stressor. The study identify a significant correlationÂ (p<0.001)between depression level and level of psychosocial stressor. . The risk of having depression is 5.87Â higher in respondents with high level of psychosocial stressor compare to those with low level psychosocialÂ stressor (OR=5.87). Therefore, a cooperation between school, community and parent is highly advised toprovide a favourable environment for mental development in adolescent. In addition parents, school need toÂ prepare the adolescent in order to anticipate numeros events that influence their mental health.
KEMAMPUAN DARI Lactobacillus plantarum GALUR IS-10506 DAN IS-20506 DALAM MENGHAMBAT AKTIVASI NFkB, MEREGULASI TURUN TNF-RECEPTOR 1 (TNF-R1) DAN OPOPTOSIS PADA BRUSH SEL EPITEL BORDER Rattus novergicus YANG DIINDUKSI LPS
Authors: Kusuma Titis Sari , Riawan Wibi , Gunadi Ranuh I Gusti Made Reza , S. Surono Ingrid 
Published: January 2017

Probiotic bacteria have a beneficial effect on diarrhea. In this study, we have examined effect of LactobacillusÂ plantarum Strain IS-10506 (LIS-10506) and IS-20506 Â (LIS-20506) on inhibition of NFÎºB activation,Â downregulation TNF Receptor-1 (TNF-R1) and Apoptosis in Epithelial Brush Border of Rattus novergicusÂ induced with LPS. On the first day, LPS was inducedto Rattus novergicus per oral. At the 3rdday,Â Lactobacillus plantarum Strain IS-10506 and LIS20506 separately were supplemented for 7 days (the 3rddayÂ up to the 9thday). Rat was sacrificed after anaesthetizing with ether to assess NFÎºB activation, TNFR1 andÂ apoptosis. Result showed the decreases of activation NFÎºB in LIS-10506 group as well as in LIS-20506Â group, significantly different, in NFÎºB activation at group with only LPS (average 14.33+4.509) compared toÂ group with LIS-10506 induction (average 2.00+1.732)and LIS-20506 induction (average 1.33+1.528), at p(Â p<0.000). Downregulation of TNF-R1 was significant Â at LPS group compared to LIS-10506 induction as wellÂ as LIS-20506 induction. The index of apoptosis showed significant of degradation (p<0.000) after induced byÂ LIS, where LPS group (14.67+2.517), LIS-10506 induction (6.33+2.309) and LIS-20506 inductionÂ (6.00+3.000). As a conclusion, supplementation of LIS-10506 and LIS-20506 separately will inhibit theNFÎºBÂ activation, and although the mechanism was not sure, what by significant degrade the expression TNF-R1(Â as ekuivalen of activity TNFÎ±), and the mentioned give the implication that happened by the degradation ofÂ occurence apoptosis at cell of epitel bush border intestine.
PROFIL KADAR SOLUBLE UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR (suPAR) PADA SERUM PENDERITA TUBERKULOSIS PARU (SEBAGAI MONITORING TERAPI)
Authors: Astuti Triwahju , MR Tri Yudani , Riawan Wibi , Muktiati Nunuk Sri , Widjajanto Edy 
Published: January 2017

Dutch study shows that Upar expression content is significantly higher in tubercolusis patientâ€™s psiphsyÂ monosit compared to those in the healthy control group. So far, there is no biologic marker used whichcanÂ accurately observe response improvement in the treatment of lung tubercolusis. The aim of this research is toÂ investigate whether the serum level of soluble utokinase plasminogen activator receptor (suPAR) carriesÂ information in monitoring TB treatment for Lung Tuberculosis patients. suPAR was measured by ELISA in 21Â individuals at the time of enrolment into observational cross sectional based on active tuberculosis Â and 5Â individuals as healthy control. There were 3 groups, 1). patients who had not started treatment (n=7),2).Â patients who had been treated for 2 months (n=7), Â 3). patients who had been treated for 6 months (n=7).Â Among groups, there were no difference in mean of body mass index, erythrocyte sedimentation rate andÂ monocyte count. Patients positive for TB on direct Â microscopy were 29% ( 6 from 21 patients) , 2 patientsÂ each groups. The suPAR levels were elevated in patients with active TB compared to healthy controlÂ (P<0,001). suPAR levels were highest in patients positive for TB on direct microscopy ( mean suPAR 4.455Â ng/ml).
PERAN LEPTIN TERHADAP AKTIVITAS MATURATION-PROMOTING FACTOR(MPF) PADA MATURASI OOSIT
Authors: Kakisina Pieter , Indra Rasyad 
Published: January 2017

Oocyte maturation is mediated by active Maturation Â Promoting Factor (MPF) in ooplasma. MaturationÂ Promoting Factor (MPF) is heterodimer protein consists of sub catalytic unit p34cdc2 and sub regulatorunit ofÂ cyclin-B. The regulation of maturation promoting factor (MPF) occures throught phosphorylation andÂ dephosphorilation Cdc2 while its activities are controlled by the accumulation and periodical degradation fromÂ Cyclin-B during cell cycles development. Leptin inknown has role on oocyte maturation that works atÂ mitogen activated protein kinase (MAPK). MAPK belongs to protein kinase family Ser/Thr that interact withÂ MPF in arranging the progresivennes of oocyte meiosis through the help of c-mos. This interaction is initiatedÂ phosphorilation of Ser-369 and Thr-577 in p90rsk.Â Key words:leptin, MPF, and oocyte maturation.
ARTERIOGENESIS DAN ANGIOGENESIS PADA STROKE HEMORAGIK:MEMPERTAJAM KONSEP UNTUK MEMPEROLEH MANFAAT TERBAIK NEOVASKULARISASI *
Authors: Lyrawati Diana 
Published: January 2017

Arteriogenesis and angiogenesis contribute both to Â the damage and repair in hemorrhagic stroke.Â Understanding and unraveling the fundamental and mechanisms of these processes should facilitate theÂ development of treatment strategies to improve outcome after stroke. This article describes briefly the basicÂ principles of arteriogenesis and angiogenesis completed with some key molecular players, followed by aperspective of the author on how to use those neovascularization to benefit repair and recovery processes inÂ post-hemorrhagic stroke.Â Key Words : arteriogenesis, angiogenesis, hemorrhagic, stroke
HASIL SATU TAHUN INTERVENSI JARINGAN PENANGGULANGAN TUBERKULOSIS PARU KECAMATAN ILIR BARAT II KOTA PALEMBANG
Authors: Tjekyan R.M. Suryadi 
Published: January 2017

AsÂ ofÂ nearlyÂ theÂ endÂ ofÂ 2007,Â NationalÂ TuberculosisÂ ProgramÂ haveÂ notÂ achievedÂ Â Â MDGâ€™SÂ indicatorÂ timely especiallyÂ inÂ SouthÂ Sumatera.Â ThisÂ wasÂ causedÂ byÂ LocalÂ andÂ NationalÂ TuberculosisÂ ControlÂ Program administeredÂ merelyÂ byÂ governmentsÂ withÂ minimalÂ privateÂ sectorÂ andÂ communityÂ participation.Â AÂ NetworkÂ of Pulmonary Tuberculosis Eradication Program was established in Ilir Barat II District of South Sumatera. This networkÂ isÂ directedÂ byÂ fourÂ componentsÂ ofÂ TBÂ control:Â cadres,Â PhysicianÂ Practitioner,Â HeadÂ ofÂ subdistrict, district local authority, and district tuberculosis program. The Network aims at accelerating TB Contol Program since first October 2006 until first October 2007. The final goal is to have â€œDistrict Free TBâ€. Theâ€Networkâ€ was foundedÂ byÂ decreeÂ ofÂ theÂ MayorÂ ofÂ IlirÂ BaratÂ IIÂ DistricÂ .Â TheÂ resultÂ ofÂ oneÂ yearÂ implementationÂ indicated significant increased of the Indicator of TB program, more than the MDGâ€™starget.Â If the networkÂ is applied at PalembangÂ cityÂ andÂ allÂ SouthÂ Sumatera,Â thoseÂ areasÂ willÂ reachÂ 100%Â conversionÂ rateÂ Â Â byÂ theÂ endÂ ofÂ Â Â 2008 and 100% case detection rate by the end of 2010. Â Keywords:Â TuberculosisÂ ControlÂ Program,Â NetworkingÂ Model,Â HealthÂ Cadre,Â PrivateÂ Physician,Â LocalÂ Government, Millenium Development Goalâ€™s
DISTRIBUSI MAST CELL PADA MESENTERIUM TIKUS
Authors: N Ibrahim Mohamad , Widjajanto Edi , Rosita Rita 
Published: January 2017

Mast cell are derived from haematopoietic progenitors in the bonemarrow. Developing mast cell subsequently migrate to peripheral tissues, such as the skin, mucosa and air way, where they terminate their differentiation underÂ theÂ influenceÂ ofÂ factorsÂ inÂ theÂ tissueÂ micro-enviroment.Â ThisÂ studyÂ aimedÂ toÂ knowÂ distributionÂ and strucutre of mast cell on rat mesentery. The mesentery was stained with a 1 % safranine solution or toluidine blueÂ onÂ theÂ aÂ peparedÂ slide.Â TheÂ preparedÂ slidesÂ wereÂ immediatelyÂ viewedÂ byÂ aÂ observerÂ throughÂ a microscope.Â TheÂ resultÂ showedÂ thatÂ mastÂ cellsÂ stainedÂ withÂ safranineÂ orÂ toluidineÂ blueÂ wereÂ closely associated with postcapillary in the rat mesentery. Keywords : mast cell, mesentery
PENGARUH PEMBERIAN CORNMEAL DAN CORNMEAL-SOY TERHADAP KADAR KOLESTEROL DALAM SERUM TIKUS
Authors: Harti Leny Budhi , Rudijanto Achmad , Kristianto Yohanes 
Published: January 2017

CoronaryÂ HeartÂ DiseasesÂ (CHD)Â areÂ aÂ seriousÂ healthÂ problemÂ thatÂ commonlyÂ occurÂ notÂ onlyÂ inÂ modern countries, but asloÂ in developing countries likeÂ Indonesia. The high cholesterol level inÂ blood isÂ a risk factor thatÂ mayÂ causeÂ CHDÂ byÂ atherosclerosisÂ mecanism.Â dietaryÂ fiberÂ mayÂ beÂ usedÂ toÂ preventÂ atherosclerosis. Cornmeal and cornmeal-soy are products of corn, that rich in fiber. This research was aimed to study about theÂ effectÂ ofÂ cornmealÂ andÂ cornmeal-soyÂ onÂ serumÂ cholesterolÂ levelÂ ofÂ 6-8Â mounthsÂ maleÂ wistarÂ rats.Â The subjectsÂ areÂ 25Â maleÂ wistarÂ rats.Â TheseÂ miceÂ willÂ beÂ providedÂ intoÂ fiveÂ groups.Â (1)Â gruopÂ thatÂ given atherogenicÂ dietÂ only,Â (2)Â gruopÂ thatÂ givenÂ atherogenicÂ dietÂ withÂ cornmealÂ 3.4Â g/day,Â (3)Â gruopÂ thatÂ given atherogenic diet with cornmeal 6.8 g/day, (4) gruop that given atherogenic diet with cornmeal-soy 3.6 g/day, (5)Â gruopÂ thatÂ givenÂ atherogenicÂ dietÂ withÂ cornmeal-soyÂ 7.2Â g/day.Â DataÂ collectingÂ includeÂ firstÂ weight,Â last weight,Â weightÂ gain,Â nutrientÂ intake,Â andÂ serumÂ lipid.Â StatisticÂ analysisÂ thatÂ beÂ usedÂ isÂ ANOVAÂ oneÂ way. Results showed thatÂ wistar rats which given atherogenic diet with cornmeal and cornmeal-soyÂ had trend to increaseÂ cholesterolÂ andÂ LDLÂ level.Â AccordingÂ toÂ statisticÂ analysis,Â cholesterolÂ andÂ LDLÂ levelÂ amongÂ groups were not significant (p > 0.05). However wistar rats which given atherogenic with cornmeal and cornmeal-soy inÂ highÂ doses,
EFEK KOMBINASI ARTEMISININ DAN N-acetylcysteineTERHADAP KADAR Malondialdehyde(MDA) OTAK DAN PARU MENCIT GALUR Balb/c YANG DIINFEKSI Plasmodium berghei
Authors: Fitri Loeki Enggar , Iskandar Agustin , Permatasari Nur , Gunawan Joko Agus , Indrawan Khadafi 
Published: January 2017

Cerebral and lung damage during malaria infection is believed to be caused by free radicals activitiesthat areÂ produced during immunology process. The free radicals react with lipid component of cellular membraneÂ which generates malondialdehyde (MDA) as its end-product. The aim of the research was to determineÂ whether combination of artemisinin and NAC was moreeffective in decreasing cerebral and lung MDA levelÂ compared to artemisinin mono-therapy . The researchwas post-test-control-only design using 5 groupsÂ consisted of group A (negative control group), group B mice which infected with P.berghei without therapyÂ (positive control group), group C mice which infected with P.berghei and received artemisinin mono-therapyÂ (0.04 mg/g BW for 7 days), group D mice which infected with P.berghei and received artemisinin inÂ combination with NAC (1 mg/g BW for 7 days) and group E mice which infected with P.berghei and receivedÂ artemisinin in combination with NAC (1 mg/g BW for 3 days and tapered into Â½ mg/g BW for 4 days). On theÂ 3rd, 5th,and 7thday, 3 mice from each group were scarified and assayed for MDA level. On the 3rdÂ day, aÂ decreasing trend of cerebral and lung MDA level wasobserved on all treatment groups. On the 5thday, aÂ decreasing trend of cerebral and lung MDA level wasobserved in group that received artemisinin and NACÂ whereas groupâ€™s that received artemisinin mono-therapy increased. Cerebral and lung MDA level of groupthat received artemisinin mono-therapy was significantly different with group that received combination ofÂ artemisinin and NAC in constant dose (p = 0.014) and with group that received combination artemisinin Â andÂ NAC in tapering dose (p = 0.004).
ANALISIS LOSS OF HETEROZYGOSITYGEN RAR Î²2 PADA PATOGENESIS KANKER PAYUDARA
Authors: Muliartha I Ketut Gede , Riawan Wibi , Hidayat Asnah , Armania Fitri 
Published: January 2017

The aim of this research was to investigate the event of loss of heterozygosity of retinoid acid receptor (RARÂ Î²2) gene on the chromosom 3p24 in the pathogenesis ofbreast cancer. The breast cancer is the mostÂ malignant tumor that leads the second cause of death among the female. The recent concept of the theory ofÂ pathogenesis breast cancer is molecular genetic approaches such as apoptosis gene, oncogen, suppressorgene, and growth promoting factor gene. However, the diagnostic and therapy of breast cancer are still notÂ satisfied. The lost or decreased in the expressionof RAR Â Î²2gene on 3p24 chromosome via loss ofÂ heterozygosity (LOH) mechanism are the role of pathogenesis of breast cancer. Design of the research is byÂ experimental and observational. Human female breastcancer and blood samples were gained from publicÂ hospital RSUD dr. Saiful Anwar, Malang. DNA was extracted from lymphocyte and tissue using Macherey-Nagel system kit. Loss of heterozygosity (LOH) incident in 3p24 chromosome was detected by PCR andÂ Chromogenic in situ Hybridization (CISH) method.
EFEK 17Î²-ESTRADIOL TERHADAP DENSITAS RESEPTOR ADRENERGIK-Î±IDDAN KONTRAKTILITAS OTOT POLOS PEMBULUH DARAH TIKUS
Authors: Nurdiana Nurdiana 
Published: January 2017

The incidence of hypertension in menopausal and post menopausal women related to plasma estrogen leveland sympathetic nervous activity. Estrogen may have a specific effect to modulate adrenergicÂ vasoconstriction by modulating adrenergic receptors. Blood vessels contractility is regulated mainly by theÂ sympathetic nervous system, in aorta mediated particularly by Â Î±1Dadrenergic receptor.We hypothesize thatÂ 17Î²estradiol decreases vascular smooth muscle contractility by decreasing Â Î±1Dadrenergic receptor density.Â To prove the above mechanism in the present study we performed several interrelated assays, i.e bioassayÂ using isolated organ and protein blotting. An isolated rat aortic ring without endothelium (2-3 month,150-200Â gram) was incubated in 17Î²-estradiol (10-5M, 10-4M,and 10-3M ) for two hours prior to stimulation usingÂ phenylephrine as Î±1Dadrenergic receptor agonist. The response of the rat aortic ring to the stimulation of Î±1Dadrenergic receptor agonist was measured as the subsequent change on aortic contractility using bioassay,Â and the change of Â Î±1Dadrenergic receptor density using Western and dotblot.
PEMBERIAN ETANOL JANGKA PANJANG MENURUNKAN MEMORI KERJA SPASIAL PADA TIKUS
Authors: Aswin Soedjono , Mustofa Mustofa 
Published: January 2017

Long term ethanol administration may cause morphological changes in the hippocampus, followed by deficit inÂ theÂ hippocampalÂ functionÂ includingÂ theÂ impairmentÂ ofÂ memory.Â TheÂ aimÂ ofÂ thisÂ studyÂ isÂ toÂ investigateÂ the changes of spatial working memory of rats after chronic ethanol administration at adolescent age. Twenty five adolescentÂ (30Â daysÂ ofÂ age)Â maleÂ ratsÂ (RattusÂ novergicus)Â dividedÂ randomlyÂ intoÂ 5Â groupsÂ :Â controlÂ without treatment (C1), control with treatment (C2), treatment 1 (T1), treatment 2 (T2), treatment 3 (T3) group. Each group consist of 5 rats. C2 group was given physiologic saline, T1, T2, and T3 group were given ethanol with dosesÂ 1,Â 2,Â andÂ 3Â g/kg/dayÂ forÂ 30Â daysÂ byÂ intraperitonealÂ injection.Â AfterÂ chronicÂ ethanolÂ administrationÂ the spatialÂ workingÂ memoryÂ ofÂ 5Â groupsÂ wereÂ testedÂ byÂ usingÂ 8Â armÂ radialÂ mazeÂ forÂ 12Â days.Â SpatialÂ working memory measured by total number of entered arm maze and error A type. The results of this study showed thatÂ chronicÂ ethanolÂ administrationÂ atÂ adolescentÂ ageÂ causedÂ decreasingÂ ofÂ spatialÂ workingÂ memoryÂ ofÂ the rats. The total number of entered arms maze and error A type for treatment group (especially P3 ) is higher thanÂ controlÂ groupsÂ (p<0,05).Â ItÂ isÂ concludedÂ thatÂ inÂ rats,Â chronicÂ ethanolÂ administrationÂ atÂ adolescentÂ age caused decreasing spatial working memory.Â Â Key words : Ethanol, Spatial working memory, Adolescent
JUMLAH SEL TROFOBLAS YANG MENGALAMI APOPTOSIS PADA PRE EKLAMPSIA/EKLAMPSIA LEBIH TINGGI DIBANDINGKAN KEHAMILAN NORMAL
Authors: Keman Kusnarman , Prasetyorini Nugrahanti , Langgar Madeline J. 
Published: January 2017

Hypoxia exposed trophoblast cells will cause apoptotic process, that correlate with up-regulation of p53 andÂ Bax protein expression; and down-regulation of anti-apoptotic Bcl-2 protein. Apoptotic process and up-regulation of p52, and down-regulation of anti-apoptotic Bcl-2; also find both on trophoblastic samplefromÂ preeclampsia/ eclampsia complicated pregnancy, and Â normal pregnancy. The aim of this study is, to proveÂ that the amount of apoptotic trophoblast cells on trophoblast tissue sample from preeclampsia/ ecclampsiaÂ complicated pregnancy, were higher then those of normal pregnancy. This research was laboratory crossÂ sectional study, that observed immunohystochemically, p53 and BCl-2 protein expression; also the DNA-fragmented technically (TUNEL) to detect apoptotic Â cells on trophoblastic samples from preeclampsia/Â eclampsia complicated pregnancy, compare by the normal pregnancy. On this study, we found that theÂ amount of trophoblast cells that expressed of p53 protein (22.70 Â± 2.90), were higher then those of normalÂ pregnancy. (8.2 Â± 4.99). The different was statistically significant. (t test; p Â â‰¤0.000). We also found that anÂ apoptotic process on trophoblast cells of preeclampsia/ eclampsia placenta (15.3 Â± 3,56) were higher Â thenÂ those of normal pregnancy (4.7 Â± 1.89). The different was statistically significant. (t test; p â‰¤0.000).
EFEK EKSTRAK BUAH TOMAT (Licopersicum pyriforme) TERHADAP EKSP KOLAGEN TIPE 1, MMP-1 DAN MMP-3 PADA PENUAAN KULIT
Authors: Wahyono Poncojari 
Published: January 2017

ABSTRACT ManyÂ theoryÂ andÂ researchÂ wasÂ tryingÂ toÂ explainÂ theÂ agingÂ process.Â FreeÂ radicalÂ theoryÂ explainedÂ thatÂ allnormal metabolism process in the body can produce free radical.These free radical can destroy the skin cell,andÂ thanÂ theÂ skinÂ willÂ startÂ theÂ agingÂ process.Â TheÂ tomatoÂ extractÂ hasÂ antioxidantÂ suchÂ asÂ lycopene,Â Î²-caroteneÂ andÂ vitaminÂ C.Â TheseÂ antioxidantÂ willÂ preventÂ theÂ activityÂ ofÂ freeÂ radical,Â soÂ thatÂ skinÂ cellÂ willÂ notdamage.Â TheÂ aimsÂ ofÂ thisÂ researchÂ wereÂ toÂ studyÂ effectÂ ofÂ tomatoÂ extractÂ juiceÂ inÂ preventingÂ skinÂ agingÂ onwistar rats. Total of 25 rats were divided into 5 groups, consisted of 5 rats each. Group one was control groupD-0) rats were four months old, and the group two control of group rats were taken care of 4 months old until7Â monthsÂ oldÂ (D-1),Â theÂ otherÂ groupÂ whichÂ wereÂ underÂ treatmentÂ classifiedÂ intoÂ 3Â groups.Â GroupÂ threeÂ wereed 7 g/kg/day/ body weight of tomato fruit extract, then taken care of 4 months old until 7 months old (D-2),group four were fed 11 g/kg/day/ body weight of tomato extract fruit, then taken care of 4 months old until 7months old (D-3) and group five were fed 15 g/kg/day/ body weigh of tomato fruit extract, then taken care of 4monthsÂ oldÂ untilÂ 7Â monthsÂ oldÂ (D-4).
ADIPONEKTIN MEREGULASI TURUN EKSPRESI iNOS PADA KULTUR HUVECâ€™s YANG DIPAPAR LIPO POLYSACCHARIDE (LPS)
Authors: Hernani Yully Endang 
Published: January 2017

ABSTRACT AdiponectinÂ isÂ aÂ adipocyteÂ derivateÂ proteinÂ involvesÂ inÂ sensitivityÂ ofÂ insulin,Â anti-inflamation,Â andÂ anti-atherogenicÂ foundÂ largelyÂ inÂ plasma.Â TheÂ decreaseÂ ofÂ adiponectinÂ inÂ theÂ plasmaÂ isÂ relatedÂ toÂ obesity, cardiovascular diseases, type II diabetes, hypertension and vascular injuries in nice. In vivo research on strain balb/c mice showed that excessive Adiponectin expression inhibits atherosclerosis with Apo E deficiency. The aimÂ ofÂ thisÂ researchÂ isÂ toÂ findÂ protectiveÂ mechanismsÂ ofÂ adiponectinÂ onÂ vascularÂ utilizingÂ in-vitroÂ Infected HUVECâ€™sÂ culture.Â ThereÂ wereÂ 5Â groupsÂ :(A)Â controlÂ negativeÂ groupÂ orÂ normalÂ HUVECâ€™s,
IDENTIFIKASI MUTASI GEN CYSTATIONINE-Î² SYNTHASE (CBS) DAN GEN METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) PADA PENDERITA PREMATUR INFARK MIOKARD AKUT DENGAN HIPERHOMOSISTEINEMI
Authors: Muliartha I Ketut Gede , Sargowo Djanggan , Iskandar Abdillah 
Published: January 2017

ABSTRACT Hyperhomocysteinemia appears to be an independent risk factor for coronary heart disease. Elevated levels ofÂ plasmaÂ totalÂ homocysteineÂ (tHcy)Â wasÂ causedÂ byÂ geneticÂ orÂ nutrient-relatedÂ disturbancesÂ inÂ the transsulfurationÂ orÂ remethylationÂ pathwaysÂ forÂ homocysteineÂ metabolism.Â ThisÂ studyÂ observedÂ premature myocardÂ infarctÂ acuteÂ patientsÂ withÂ hyperhomocysteinemia.TheÂ aimÂ ofÂ theÂ researchÂ wasÂ toÂ determine Cystarhionine-Î²Â SynthaseÂ andÂ MethylenetetrahydrofolateÂ ReductaseÂ genesÂ mutationsÂ inÂ prematureÂ acute myocardÂ infarctÂ patientsÂ withÂ hyperhomocysteinemia.ThisÂ studyÂ wasÂ aÂ crossÂ sectionalÂ studyÂ inÂ premature acute myocard infarct patients. Twenty three patients were examined for plasma total homocysteine, vitamin B6, vitamin B12 folic acid and lipid profile. Total DNA isolated from patients with hyperhomocystememia and normalÂ folicÂ acid,Â vitaminÂ B6,Â vitaminÂ B12Â levelsÂ andÂ lipidÂ profile.Â FiveÂ patientsÂ wereÂ assayedÂ for Cystathionine-Î²Â SynthaseÂ andÂ genÂ MethylenetetrahydrofolateÂ ReductaseÂ geneseÂ mutationsÂ byÂ Polymerase ChainÂ ReactionsÂ (PCR).Â FiveÂ fromÂ 23Â patientsÂ (Â 21,7%Â )Â plasmaÂ total
STUDI KUALITATIF PENGAMBILAN KEPUTUSAN DALAM KELUARGA TERKAIT DENGAN KOMPLIKASI PERINATAL DI KABUPATEN CIANJUR JAWA BARAT
Authors: Melani Asti 
Published: January 2017

ABSTRACT The high number of maternal mortality rate caused by 3 complex problems. One of those problems was delay identificationÂ byÂ theÂ familyÂ onÂ theÂ riskÂ factorsÂ ofÂ theÂ maternalÂ andÂ makeÂ decisionÂ inÂ seekingÂ helpÂ relatedÂ to their problem. The goal of this study was to identify how the family involvement role, especially their husband, to the maternal health and how the decision making pattern in the family, related to the perinatal complication. ThisÂ studyÂ isÂ qualitativeÂ researchÂ usingÂ phenomenologyÂ approach.Â TheÂ numberÂ ofÂ participantÂ inÂ thisÂ study were six couples husband and wife in Bojongherang, Cianjur, West Java. The findings identified that most of the decision maker in the family were the husbands, except those wife who are the carrier woman. In general, the process of decision making start with discussion from both husband and wife before the decision making is made. Some other is decided by their husband instead. The most influenced factors to the decision making process were socio-economic, accessibility to the health insurance and the family knowledge on the perinatal complications.Â TheÂ otherÂ lessÂ influencedÂ factorsÂ wereÂ gender,Â educationalÂ backgroundÂ andÂ cultural background. Â Key words : Decision making in the family,perinatal complication, maternal health.