bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED ARTICLE: BCORL1 is an independent prognostic marker and contributes to cell migration and invasion in human hepatocellular carcinoma
Authors: Yin Guozhi , Liu Zhikui , Wang Yufeng , Dou Changwei , Li Chao , Yang Wei , Yao Yingmin , Liu Qingguang , Tu Kangsheng 
Published: February 2016

Abstract
Background
The deregulation of E-cadherin has been considered as a leading cause of hepatocellular carcinoma (HCC) metastasis. BCL6 corepressor-like 1 (BCORL1) is a transcriptional corepressor and contributes to the repression of E-cadherin. However, the clinical significance of BCORL1 and its role in the metastasis of HCC remain unknown.

Methods
Differentially expressed BCORL1 between HCC and matched tumor-adjacent tissues, HCC cell lines and normal hepatic cell line were detected by Western blot. The expression of BCORL1 was altered by siRNAs or lentivirus-mediated vectors. Transwell assays were performed to determine HCC cell invasion and migration.

Results
Increased expression of BCORL1 protein was detected in HCC specimens and cell lines. Clinical association analysis showed that BCORL1 protein was expressed at significant higher levels in HCC patients with multiple tumor nodes, venous infiltration and advanced TNM tumor stage. Survival analysis indicated that high expression of BCORL1 protein conferred shorter overall survival (OS) and recurrence-free survival (RFS) of HCC patients. Multivariate Cox regression analysis disclosed that BCORL1 expression was an independent prognostic marker for predicting survival of HCC patients. Our in vitro studies demonstrated that BCORL1 prominently promoted HCC cell migration and invasion. Otherwise, an inverse correlation between BCORL1 and E-cadherin expression was observed in HCC tissues. BCORL1 inversely regulated E-cadherin abundance and subsequently facilitated epithelial-mesenchymal transition (EMT) in HCC cells. Notably, the effect of BCORL1 knockdown on HCC cells was abrogated by E-cadherin silencing.

Conclusions
BCORL1 may be a novel prognostic factor and promotes cell migration and invasion through E-cadherin repression-induced EMT in HCC.
Formal specification and analysis of take-off procedure using VDM-SL
Authors: Zafar Nazir Ahmad 
Published: February 2016

Abstract

Purpose
Air traffic management system is a complex adaptive and safety critical system which requires considerable attention for its modelling and verification. Currently Air traffic control (ATC) systems are heavily dependent upon human intervention at airport causing accidents and delays because of failure of communication. The purpose of this study is to develop, plan, manage and verify aircrafts movement procedures at the airport surface that prevent delays and collisions.

Methods
The airport surface is decomposed into blocks and represented by the graph relation. The state space of the system is described by identifying all the possible components of the system. The ground and local controls monitor queues of the aircrafts moving from taxiway to take-off. It is insured that once an aircraft is inserted into a queue, it is eventually removed from it after the next queue has become available. The take-off procedure is provided using graph theory and Vienna Development Method Specification Language (VDM-SL) and analyzed using VDM-SL toolbox.

Results
Formal specification of graph-based model, taxiways, aircrafts, runways and controllers is provided in static part of the model. The state space analysis describing take-off algorithms is provided by defining optimal paths and possible operations in dynamic model expediting the departure procedure. The model is developed by a series of refinements following the stepwise development approach.

Conclusions
The delays at airport surface require effective safety and guidance protocols to control air traffic at the airport. In static model, the safety criteria are described in terms of invariants over the data types carrying critical information. The safety is insured by defining pre/post conditions in description of operations for changing state space of the system. Although the proposed study is focussed more on the safety component, however, the efficiency is not ignored.
Use of novel high-resolution 3D marine seismic technology to evaluate Quaternary fluvial valley development and geologic controls on shallow gas distribution, inner shelf, Gulf of Mexico
Authors: Meckel Timothy A. , Mulcahy Francis J. 
Published: February 2016

The first deployment of the P-Cable™ high-resolution 3D (HR3D) seismic acquisition system in the Gulf of Mexico has provided unprecedented resolution of depositional, architectural, and structural features related to relative sea-level change recorded in the Quaternary stratigraphy. These details are typically beyond conventional 3D seismic resolution and/or excluded from commercial surveys, which are generally optimized for deeper targets. Such HR3D data are valuable for detailed studies of reservoir analogs, sediment delivery systems, fluid-migration systems, and geotechnical hazard assessment (i.e., drilling and infrastructure). The HR3D survey ([Formula: see text]) collected on the inner shelf ([Formula: see text] water depth) offshore San Luis Pass, Texas, imaged the upper 500 m of stratigraphy using peak frequency of 150 Hz and [Formula: see text] bin size. These data provided an exceptionally well-imaged example of shallow subsurface depositional system and stratigraphic architecture development during a lowstand period. The system evolved from a meandering channel with isolated point-bar deposits to a transgressive estuary characterized by dendritic erosional features that were eventually flooded. In addition, HR3D data have identified a previously unidentified seismically discontinuous zone interpreted to be a gas chimney system emanating from a tested (drilled) nonproductive, three-way structure in the lower Miocene (1.5 km depth). Within the shallowest intervals ([Formula: see text]) and at the top of the chimney zone, seismic attribute analysis revealed several high-amplitude anomalies up to [Formula: see text]. The anomalies were interpreted as reaccumulated thermogenic gas, and their distribution conforms to the stratigraphy and structure of the Quaternary interval, in that they occupy local fault-bounded footwall highs within remnant coarser-grained interfluvial zones, which are overlain by finer grained, transgressive deposits.
Rulers, businessmen, suspicious people, institutions and corruption: the origin of chaos
Authors: De Oliveira Artur Gomes , Nunes Paulo Roberto de Carvalho , Oliveira Francisco Correia 
Published: February 2016

Through the comparison between the actions and accomplishments of the Baron of Mauá at the time of the Brazilian Empire and some current events, like the links among suspected citizens, politicians and businessmen, this teaching case aims to highlight that institutions, whether formal or informal, have been playing a significant role in society and have, over time, been influenced by several events and people. The case serves as a pedagogical instrument to show, in practice, the applicability of theoretical concepts in disciplines related to Theory of Chaos, entry into new markets, Strategy (Resource-Based View, Industry-Based View, Institutions–Based View) and Governance.DOI: 10.12660/gvcasosv5n2c10http://dx.doi.org/10.12660/gvcasosv5n2c10
Ocean Films: os desafios de uma empresa de production services
Authors: Matta João Ricardo Nobre , De Mello Renato Cotta , Bellini Luciana Penna 
Published: February 2016

Com sede na cidade do Rio de Janeiro, a Ocean Films é uma empresa em expansão, que atua no setor de economia criativa, no segmento de production services. Ela provê toda a infraestrutura necessária a produtoras de filmes cinematográficos, televisivos e publicitários. Criada para atender, exclusivamente, às demandas oriundas do mercado internacional, a empresa é líder nesse segmento no Brasil, e nos últimos dois anos passou a produzir, também, alguns poucos conteúdos para emissoras de TV nacionais. Hoje, ela se encontra diante de uma importante tomada de decisão com relação ao seu crescimento futuro: como expandir seus negócios internacionais? Deveria a empresa dedicar-se também ao mercado brasileiro? O caso destina-se a uso em programas de pós-graduação stricto e lato sensu, em disciplinas de Marketing Internacional, Empreendedorismo Internacional e Negócios Internacionais. Pode também ser utilizado em programas de executivos voltados para o setor de serviços e, especificamente, para o setor de audiovisual. DOI: 10.12660/gvcasosv5n2c14http://dx.doi.org/10.12660/gvcasosv5n2c14
Αλεξάνδρου Δ. Ζάννα, Αναμνήσεις από τον Α' Παγκόσμιο Πόλεμο. Η παλινόστησις των ομήρων της Ανατολικής Μακεδονίας
Authors: Παπαστάθης Χαράλαμπος Κ. 
Published: February 2016

<p>No abstract </p>
The Status of Microvascular Reactivity in Infertile and Fertile Patients with Chronic Prostatitis
Authors: Полунин  , Polunin A. , Садретдинов  , Sadretdinov R. , Воронина  , Voronina L. 
Published: February 2016

The study covered 280 patients with chronic prostatitis (CP) on the background of sexually
transmitted infections. Patients with chronic prostatitis were divided into 2 patient groups: infertile males
(140) and fertile males (140). The control group consisted of 50 somatically healthy males of a reproductive
age. To assess the functional state of skin microvessels in the projection of the prostate gland, the authors
used the method of laser Doppler flowmetry supplemented by iontophoretic probes with sodium nitroprusside
and acetylcholine. It has been proved that the development of infertility in patients with chronic prostatitis
is associated with a number of microvascular disorders. In the infertile male group with chronic prostatitis
the authors observed a marked inflammatory hyperemia and a decrease in the microvascular response
to a sympathetic and tonic stimulation. Not only was the direct microvascular vasodilation under the influence
of sodium nitroprusside reduced, but the production of their own vasodilators under the influence of
acetylcholine as well, indicating the development of endothelial dysfunction. The peculiarity of the microvascular
endothelial reaction to iontophoresis of endothelium‐dependent vasodilator (acetylcholine) in the
infertile patients with chronic prostatitis was the slowdown of the development of vasodilation with its
quicker cessation, unlike the fertile patients who, on the contrary, developed vasodilation faster than the
control group.
The Aexperience of the Organization and the Screening of Pregnant Women for the Purpose of Detecting Sexually Transmitted Infections, in the Framework of the Regional Program of the Tula Region
Authors: Анисимова  , Anisimova N. , Долгова  , Dolgova T. , Суханова  , Sukhanova L. , Руднева  , Rudneva N. , Гущин  , Gushchin A. 
Published: February 2016

Sexually transmitted infections (STIs) have a negative impact on the reproductive health of
women, complicate pregnancy, leading to ante ‐ and perinatal losses, worsen demographic situation. The
greatest role in the development of complications due to STIs is given a chlamydial, gonococcal, Trichomonas,
Mycoplasma, infections, which often lead to miscarriage, premature birth, stillbirth, prenatal rupture of
amniotic membranes, to the birth of a child with low birth weight, intrauterine infections, postnatal endometritis.
Organization of massive screening of pregnant women for early STIs detection is a relevant problem of
public health. The use of modern methods of molecular diagnostics with the use of multiprime research allows
to examining the greatest number of pregnant women in a short time. Early STIs diagnosis in pregnant
women, timely treatment of infected women provides an opportunity to prevent complications during preg nancy and neonatal period. In this study the analysis of the prevalence of chlamydia, gonorrhea, Trichomonas
and Mycoplasma infection among pregnant women of the Tula region and the comparison the effectiveness
of diagnosing gonorrhea and Trichomonas infections in microscopic and molecular‐biological research
as a result of the screening in the framework of realization of the regional program were carried out.
The Effects of Individual Vitamin and Mineral Complex on Some Parameters of Physical Capacity and Blood Oxidative Metabolism in Athletes
Authors: Мартусевич  , Martusevich A. , Карузин  , Karuzin K. 
Published: February 2016

The purpose of this work was the estimation of the effects of the individual technology of metabolic
correction on the parameters of the physical capacity and blood oxidative processes in athletes. The
authors studied physical capacity indexes and blood oxidative metabolism (by total antioxidant capacity and
activity of superoxide dismutase) in 24 athletes of main group (with vitamin and mineral complex) and 30
sportsmen, which got a placebo. It was stated the positive effect of investigated complex on the physical capacity,
is realized through the directed optimization of the blood oxidative metabolism, first of all – antioxidant
enzymes.
Healthcare law and ethics, 1: a general introduction
Authors: Barber Chris 
Published: February 2016

Healthcare law and healthcare ethics are major aspects of the working lives of all healthcare professionals, including healthcare assistants (HCAs) and, given the nature of the healthcare world in which these healthcare professionals work, are likely to be increasingly important. This new series on healthcare law and healthcare ethics will explore the relevance and importance of such law and ethics within the working lives of HCAs. This first article aims to set the scene.
The NHS Wales Skills and Career Framework for Healthcare Support Workers
Authors: Callaghan Tessa , Groves Krysia , Hargest Liz , Middlemiss Charlette 
Published: February 2016

Workforce Education and Development Services (WEDS) supports NHS Wales and the Welsh Government to ensure Wales has a skilled workforce that meets the demands of modern healthcare. It has developed an important workforce resource to support and ensure that HCSWs in Wales are highly skilled and fully competent to deliver care to patients/service users. Welsh Government minister for health and social services, Mark Drakeford AM, launched the academically accredited Skills and Career Framework for Healthcare Support Workers (HCSWs) in November 2015. The framework supports HCSWs, from initial induction, through their career progression, to retirement. It will be introduced across NHS Wales from April 2016 for all new HCSWs, and will be mandated for all existing HCSWs from 2018. Corporate and clinical induction will now have to be successfully completed before any newly recruited HCSW can start working in a clinical area.
Late costal osteomyelitis with a cutaneous fistula after flame burns: a case report
Authors: Gaucher S. , Bobbio A. , Mansuet-Lupo A. , Hamelin-Canny E. , Hautier A. , Nicolas C. , Alifano M. 
Published: February 2016

Chest wall defects are an unusual complication of burn injury, generally seen after high-voltage electrical burns. Here we report the case of a 57-year-old man who developed costal chondritis and osteomyelitis 23 months after flame injury, which covered 50% of the total body surface area. Management included the resection of two ribs and coverage with an omental flap, overlaid by a split-thickness skin graft during the same surgical procedure. Declaration of interest: The authors have no conflict of interest to declare.
Photoacoustic imaging of real-time oxygen changes in chronic leg ulcers after topical application of a haemoglobin spray: a pilot study
Authors: Petri M. , Stoffels I. , Jose J. , Leyh J. , Schulz A. , Dissemond J. , Schadendorf D. , Klode J. 
Published: February 2016

Objective: To use a non-invasive measurement of oxygen saturation in chronic leg ulcers after the application of a topical haemoglobin spray to investigate if photoacoustic tomography is able to measure the oxygen saturation and if the stimulated oxygen increase can be demonstrated. Method: We measured the oxygen saturation of the ulcer tissue in five patients with chronic leg ulcers before application and 5 and 20 minutes after application of the haemoglobin spray, using photoacoustic tomography as a new method to assess oxygenation in real-time. Results: The average oxygen saturation showed a significant increase from 56.4% before to 69% (p=0.042) after 5 minutes and 78.8% (p=0.043) 20 minutes after the topical haemoglobin application. Conclusion: The oxygenation status of chronic, hard-to-heal wounds is gaining increasing interest in modern wound therapy. Topical haemoglobin spray is a new and effective method to increase the oxygenation in the ulcer tissue, but until now the link between clinical results and the mode of action was unclear. We were able to show for the first time that the use of a topical haemoglobin spray leads to an increase in oxygen saturation in vivo using photoacoustic tomography. Declaration of interest: Joachim Dissemond received financial support from the company SastoMed for several scientific projects as well as for lectures and as an advisor. The haemoglobin spray was provided by SastoMed GmbH (Georgsmarienhütte, Germany).
Healing of chronic sickle cell disease-associated foot and ankle wounds using transdermal continuous oxygen therapy
Authors: Massenburg B. B. , Himel H. N. 
Published: February 2016

Objective Sickle cell disease (SCD) is a complex cause of capillary stasis that can lead to lower extremity venous ulcers. Since SCD is characterised by impaired oxygen delivery that can be exacerbated by lower extremity venous stasis, we sought to determine if direct delivery of oxygen to a lower extremity ulcer associated with SCD could augment healing. Method We performed a pilot study of a portable device that delivers oxygen directly to the wound site to assess this possibility. The device was assessed in a single patient with three longstanding wounds of the lower extremities associated with SCD: the lateral right ankle, the medial aspect of the distal left leg, and the dorsal left foot. The left leg and left foot wounds received 15 weeks of treatment each. Results Both left lower extremity wounds healed, and neither wound has relapsed in the 42 months since the treatment was completed. At 36 months from the completion of treatment, the patient presented to the hospital with renal failure, and with the 27 days of complete bed rest and wound elevation, the right ankle wound shrunk to 55% of the original wound surface area. Transdermal oxygen appears to have assisted in healing and to have provided a sustained benefit that has delayed relapse of the two SCD-associated leg ulcers that received an extended course of treatment. Similarly, complete bed rest appears to aid in the healing of SCD-associated leg ulcers. Further study is needed to determine the mechanism of action and the optimal method of use of the transdermal continuous oxygen delivery device for SCD-associated lower extremity ulcers. Declaration of interest: No competing financial interests exist for any author. The content of this article was expressly written by the authors listed. No ghostwriters were used to write this article.
Comparative characterization of Macaranga species collected from secondary forests in East Kalimantan for biorefinery of unutilized fast growing wood
Authors: AMIRTA RUDIANTO , NAFITRI SYAFFIYA ISNU , WULANDARI RETNO , YULIANSYAH YULIANSYAH , SUWINARTI WIWIN , CANDRA KRISHNA PURNAWAN , WATANABE TAKASHI 
Published: February 2016

Amirta R, Nafitri SI, Wulandari R, Yuliansyah, Suwinarti W, Candra KP, Watanabe T. 2016. Comparative characterization of Macaranga species collected from secondary forests in East Kalimantan for biorefinery of unutilized fast growing wood. Biodiversitas 17: 116-123. Wood species for industrial forest plantation has been selected to produce construction wood materials, boards and papers,and unutilized fast growing wood as a source for biofuel production has been out of the scope for selection. Macaranga Thouars (Euphorbiaceae)Â
is widely distributed in the tropics and importance of the genus has been recognized due to its high level of growth rateand adaptability to constitute forest ecosystem. However, potency of the genus as a source for bioethanol production has not beensystematically studied. We herein first report differential properties of six Macaranga wood species collected in East Kalimantan,Indonesia, as a raw feedstock for enzymatic saccharification for bioethanol production. Among the wood species examined, the highestsugar yield 48.6% (weight of original wood basis), which corresponds to 315 mL ethanol/kg biomass, was obtained with 5.0% NaOH at 160ÂºC for M. hypoleuca. Significant differences in the sensitivity to alkaline concentration and temperature have been found among the species. A high sugar yield, 40.4% was obtained for M. winkleri with a low alkaline concentration, 3.5% NaOH at 150ÂºC, while M. motleyana gave the sugar yield 12.8% under the same condition. M. motleyana required a set of the conditions with higher NaOH concentration 5.0% and temperatures over 160ÂºC. The harsh condition with 5.0% NaOH at 170ÂºC promoted delignification of all the species but M. hypoleuca decreased the saccharification yield by raising the temperature from 160ÂºC to 170ÂºC, probably due to decomposition of carbohydrate cores. This temperature-dependent negative effect was not observed with 3.5% NaOH for M. hypoleuca. These results indicate that differences in the balance between disintegration effects and excess degradation of carbohydrates are differentÂ among the species and the variation should be taken into account on screening. Thus, we found a wide range of diversity in the susceptibility to alkaline pretreatment in the genus Macaranga and selected the wood species giving high productivity of fermentable sugars.
The politics of pity and the individual heroine syndrome: Mukhtaran Mai and Malala Yousafzai of Pakistan
Authors: Afzal-Khan Fawzia 
Published: February 2016

Abstract
Using Lilie Chouliarki’s questions regarding the ethical responsibilities of spectators towards visual suffering in our mediatized age as a start-off point, wherein she states, ‘the mediation between spectator and sufferer is a crucial political space because the relationship between the two of them maps on to distinct geopolitical territories that reflect the global distribution of power’, this article looks at a recently staged operatic performance in NYC about the story of Mukhtar Mai’s rape called Thumbprint, as well as the performative memoir I am Malala (2013) by Malala Yousafzai and Christina Lamb. This article raises the following questions: is Thumbprint a ‘spectacular performance’? Does it reproduce the image of the ‘third-world woman as monolith’ – or did it allow for the figure of Mukhtaran (as she is sometimes called) to speak to the audience assembled at Baruch Performing Arts Center in ways that brought forth the historical context of Pakistani and US politics? Does Malala’s self-representation in her memoir, her staging of herself as the ‘voice’ of a Pakistani young woman, similarly exemplify the competing motives animating the spectacle of being placed in the center of a supposedly ‘universalist’ human rights discursive framework? How far do these two women’s performances of Self/Voicing (as presented in the theatre of the West) – force us to ask anew, ‘Can the Subaltern Speak?’. To what extent do these two performative instances of ‘voicing the other’ call attention to the West’s ongoing obsession with ‘the cultural politics of recognition’, which, based on an ‘identity-based politics of visibility’, has dominated western liberal feminism since the end of the twentieth century, and been responsible for directing ‘public attention away from the regressive politics and growth of global capitalism’– and which in turn is implacably intertwined with the politics of US Empire in the twenty-first century? How do these two performances of individual women refusing victimhood feed, paradoxically, into a neo-liberal politics of redemption?