bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-linear aeroelastic analysis in the time domain of high-aspect-ratio wings: Effect of chord and taper-ratio variation
Authors: Suleman A. , Afonso F. , Vale J. , Oliveira É. , Lau F. 
Published: September 2016

ABSTRACTCommercial jets usually have relatively low-aspect-ratio wings, in spite of the associated benefits of increasing the wing aspect-ratio, such as higher lift-to-drag ratios and ranges. This is partially explained by the fact that the wing becomes more flexible by increasing the aspect-ratio that results in higher deflections which can cause aeroelastic instability problems such as flutter. An aeroelastic computational framework capable of evaluating the effects of geometric non-linearities on the aeroelastic performance of high-aspect-ratio wings has been developed and validated using numerical and experimental data. In this work, the aeroelastic performance of a base wing model with 20 m span and 1 m chord is analysed and the effect of changing the wing chord or the taper-ratio is determined. The non-linear static aeroelastic equilibrium solutions are compared in terms of drag polar, root bending moment and natural frequencies, and the change in the flutter speed boundary is assessed as a function of aspect-ratio using a time-marching approach.
Perioperative Quality of Life in Cushing’s Disease
Authors: Ye Vincent Chen , Akagami Ryojo 
Published: September 2016

AbstractBackground: Our study evaluated the perioperative quality of life (QoL) in Cushing’s disease (CD) patients, along with correlations between patient variables and cure rate. Methods: The 36-item Short-Form Health Survey (SF)-36 questionnaire was used to assess perioperative QoL. Patients completed one survey preoperatively and two surveys postoperatively. Retrospective chart review was conducted to collect SF-36 data as well as examine variables including: age, hospital stay, size of tumour, pathological diagnosis, timing of cure, and complication rates. Statistical analysis was conducted on the scores reported by the SF-36, and were compared with the normal Canadian population values, and to a sample of QoL from nonfunctioning pituitary tumour patients. This project was approved by University of British Columbia Research Ethics Board #H15-01572. Results: In general, CD patients have relatively poor QoL that does improve as expected when cured, but not quite to normal levels. Factors associated with cure included presence of macroadenoma, confirmatory pathology, and patient age. Postoperative timing of cure appears to affect the durability of cure, with an immediate cure having a higher durability rate than delayed cure. Most recurrences occurred within 10 months postoperatively. Conclusions: This review of the perioperative QoL in CD helps to illustrate how QoL changes throughout the treatment process, how QoL compares to normal Canadian population levels, and how QoL compares to patients with nonfunctioning pituitary adenomas. As treatment outcome has such a high impact on QoL, the variables identified in this study will help to better inform patients about the treatment course.
Role of CD46 Polymorphisms in the Occurrence of Disease in Young Chinese Men With Human Adenovirus Type 55 Infection
Authors: Lv Qi , Ding Hui , Liu Zi-quan , Gao Hong-wei , Yu Bao-guo , Wu Zhou-wei , Fan Hao-jun , Hou Shi-ke 
Published: September 2016

AbstractObjectiveHuman adenovirus type 55 (HAdV-55) has recently caused multiple outbreaks. This study examined polymorphisms in CD46 to determine their involvement in HAdV-55 infection.MethodsA total of 214 study subjects infected with HAdV-55 were included in our study. The study subjects were divided into those with silent infections (n=91), minor infections (n=85), and severe infections (n=38). Ten single nucleotide polymorphisms (SNPs) from CD46 were examined.ResultsCompared with the AA genotype, the TT genotype at rs2724385 (CD46, A/T) was associated with a protective effect against disease occurrence, with an odds ratio (95% confidence interval) of 0.20 (0.04-0.97) (P=0.038). There were no significant differences between the patients with minor and severe infection and those who had silent HAdV-55 infection in the other CD46 SNPs. We next compared the polymorphisms of these genes according to disease severity in HAdV-55-infected patients with clinical symptoms. The results showed that there were no significant differences between minor infections and severe infections.ConclusionsOur results suggested that the CD46 SNP at rs2724385 is associated with the occurrence of disease in HAdV-55-infected patients. A much larger number of samples is required to understand the role of CD46 polymorphisms in the occurrence and progression of infection by HAdV-55. (Disaster Med Public Health Preparedness. 2018;12:427–430)
Global effect of local skin friction drag reduction in spatially developing turbulent boundary layer
Authors: Stroh A. , Hasegawa Y. , Schlatter P. , Frohnapfel B. 
Published: September 2016

A numerical investigation of two locally applied drag-reducing control schemes is carried out in the configuration of a spatially developing turbulent boundary layer (TBL). One control is designed to damp near-wall turbulence and the other induces constant mass flux in the wall-normal direction. Both control schemes yield similar local drag reduction rates within the control region. However, the flow development downstream of the control significantly differs: persistent drag reduction is found for the uniform blowing case, whereas drag increase is found for the turbulence damping case. In order to account for this difference, the formulation of a global drag reduction rate is suggested. It represents the reduction of the streamwise force exerted by the fluid on a plate of finite length. Furthermore, it is shown that the far-downstream development of the TBL after the control region can be described by a single quantity, namely a streamwise shift of the uncontrolled boundary layer, i.e. a changed virtual origin. Based on this result, a simple model is developed that allows the local drag reduction rate to be related to the global one without the need to conduct expensive simulations or measurements far downstream of the control region.
Morphometric and molecular analyses of Skrjabinolecithum pyriforme n. sp. (Digenea: Haploporidae) in mullet fish from the Primorsky Region, Russia
Authors: Besprozvannykh V.V. , Atopkin D.M. , Ermolenko A.V. , Beloded A.Yu. 
Published: September 2016

AbstractA new species of Skrjabinolecithum (Digenea: Waretrematinae), Skrjabinolecithum pyriforme n. sp., has been found in the intestines of Liza haematocheila and Mugil cephalus from the Primorsky Region, Russia. These worms differ from S. vitellosum and S. lobolecithum by the presence of two caeca, as do S. spasskii, S. indicum and S. bengalensis. These species differ morphologically from S. pyriforme n. sp. by a number of features, including body width, oral sucker, pharynx, eggs and ratio of length and width of the body. The most similar species to S. pyriforme n. sp. is Platydidymus flecterotestis (Zhukov, 1971) with some differences in maximal body length, testis and egg sizes. The results of molecular analysis confirmed that this new species belongs to Skrjabinolecithum on the basis of close relationships with S. spasskii-type species.
Does Internet-based guided-self-help for depression cause harm? An individual participant data meta-analysis on deterioration rates and its moderators in randomized controlled trials
Authors: Ebert D. D. , Donkin L. , Andersson G. , Andrews G. , Berger T. , Carlbring P. , Rozenthal A. , Choi I. , Laferton J. A. C. , Johansson R. , Kleiboer A. , Lange A. , Lehr D. , Reins J. A. , Funk B. , Newby J. , Perini S. , Riper H. , Ruwaard J. , Sheeber L. , Snoek F. J. , Titov N. , Ünlü Ince B. , van Bastelaar K. , Vernmark K. , van Straten A. , Warmerdam L. , Salsman N. , Cuijpers P. 
Published: September 2016

BackgroundAlmost nothing is known about the potential negative effects of Internet-based psychological treatments for depression. This study aims at investigating deterioration and its moderators within randomized trials on Internet-based guided self-help for adult depression, using an individual patient data meta-analyses (IPDMA) approach.MethodStudies were identified through systematic searches (PubMed, PsycINFO, EMBASE, Cochrane Library). Deterioration in participants was defined as a significant symptom increase according to the reliable change index (i.e. 7.68 points in the CES-D; 7.63 points in the BDI). Two-step IPDMA procedures, with a random-effects model were used to pool data.ResultsA total of 18 studies (21 comparisons, 2079 participants) contributed data to the analysis. The risk for a reliable deterioration from baseline to post-treatment was significantly lower in the interventionv. control conditions (3.36v. 7.60; relative risk 0.47, 95% confidence interval 0.29–0.75). Education moderated effects on deterioration, with patients with low education displaying a higher risk for deterioration than patients with higher education. Deterioration rates for patients with low education did not differ statistically significantly between intervention and control groups. The benefit–risk ratio for patients with low education indicated that 9.38 patients achieve a treatment response for each patient experiencing a symptom deterioration.ConclusionsInternet-based guided self-help is associated with a mean reduced risk for a symptom deterioration compared to controls. Treatment and symptom progress of patients with low education should be closely monitored, as some patients might face an increased risk for symptom deterioration. Future studies should examine predictors of deterioration in patients with low education.
Mental illness and suicide after self-harm among young adults: long-term follow-up of self-harm patients, admitted to hospital care, in a national cohort
Authors: Beckman K. , Mittendorfer-Rutz E. , Lichtenstein P. , Larsson H. , Almqvist C. , Runeson B. , Dahlin M. 
Published: September 2016

BackgroundSelf-harm among young adults is a common and increasing phenomenon in many parts of the world. The long-term prognosis after self-harm at young age is inadequately known. We aimed to estimate the risk of mental illness and suicide in adult life after self-harm in young adulthood and to identify prognostic factors for adverse outcome.MethodWe conducted a national population-based matched case-cohort study. Patients aged 18-24 years (n = 13 731) hospitalized after self-harm between 1990 and 2003 and unexposed individuals of the same age (n = 137 310 ) were followed until December 2009. Outcomes were suicide, psychiatric hospitalization and psychotropic medication in short-term (1-5 years) and long-term (>5 years) follow-up.ResultsSelf-harm implied an increased relative risk of suicide during follow-up [hazard ratio (HR) 16.4, 95% confidence interval (CI) 12.9–20.9). At long-term follow-up, 20.3% had psychiatric hospitalizations and 51.1% psychotropic medications, most commonly antidepressants and anxiolytics. There was a six-fold risk of psychiatric hospitalization (HR 6.3, 95% CI 5.8–6.8) and almost three-fold risk of psychotropic medication (HR 2.8, 95% CI 2.7–3.0) in long-term follow-up. Mental disorder at baseline, especially a psychotic disorder, and a family history of suicide were associated with adverse outcome among self-harm patients.ConclusionWe found highly increased risks of future mental illness and suicide among young adults after self-harm. A history of a mental disorder was an important indicator of long-term adverse outcome. Clinicians should consider the substantially increased risk of suicide among self-harm patients with psychotic disorders.
Great power management and ambiguous order in nineteenth-century international society
Authors: Zala Benjamin 
Published: September 2016

AbstractThis article considers what the nineteenth century can tell us about the nature of great power management under conditions of ambiguity in relation to the holders of great power status. It charts the development of an institutionalised role for the great powers as managers of international society but with a specific focus on the mutual recognition, and conferral, of status. Such a focus highlights the changing, and sometimes competing, perceptions of not only which states should be thought of as great powers, but also therefore whether the power structure of international society remained multipolar or shifted towards bipolarity or even unipolarity. The article argues that a ‘golden age’ of great power management existed during a period in which perceptions of great power status were in fact more fluid than the standard literature accounts for. This means that predictions surrounding the imminent demise of the social institution of great power management under an increasingly ambiguous interstate order today may well be misplaced.
How does poverty affect children’s nutritional status in Nairobi slums? A qualitative study of the root causes of undernutrition
Authors: Goudet Sophie M , Kimani-Murage Elizabeth W , Wekesah Frederick , Wanjohi Milka , Griffiths Paula L , Bogin Barry , Madise Nyovani J 
Published: September 2016

AbstractObjectiveChildren in slums are at high risk of undernutrition, which has long-term negative consequences on their physical growth and cognitive development. Severe undernutrition can lead to the child’s death. The present paper aimed to understand the causes of undernutrition in children as perceived by various groups of community members in Nairobi slums, Kenya.DesignAnalysis of ten focus group discussions and ten individual interviews with key informants. The main topic discussed was the root causes of child undernutrition in the slums. The focus group discussions and key informant interviews were recorded and transcribed verbatim. The transcripts were coded in NVivo by extracting concepts and using a constant comparison of data across the different categories of respondents to draw out themes to enable a thematic analysis.SettingTwo slum communities in Nairobi, Kenya.SubjectsWomen of childbearing age, community health workers, elders, leaders and other knowledgeable people in the two slum communities (n 90).ResultsParticipants demonstrated an understanding of undernutrition in children.ConclusionsFindings inform target criteria at community and household level that can be used to identify children at risk of undernutrition. To tackle the immediate and underlying causes of undernutrition, interventions recommended should aim to: (i) improve maternal health and nutrition; (ii) promote optimal infant and young children feeding practices; (iii) support mothers in their working role; (iv) increase access to family planning; (v) improve water, sanitation and hygiene (WASH); (vi) address alcohol problems at all levels; and (vii) address street food issues with infant feeding counselling.
Mortality forecasting using a modified Continuous Mortality Investigation Mortality Projections Model for China I: methodology and country-level results
Authors: Huang Fei , Browne Bridget 
Published: September 2016

AbstractIn this paper, we project future mortality rates for actuarial use with Chinese data using a modified Continuous Mortality Investigation (CMI) Mortality Projections Model. The model adopts a convergence structure from “initial” to “long-term” rates of mortality improvement as the process of projection. The initial rates of mortality improvement are derived using two-dimensional P-spline methodology. Given the short history of Chinese data, the long-term rates of mortality improvement are determined by borrowing information from international experience. K-means clustering with dynamic time warping distance is used to classify populations, which is novel in the actuarial mortality research field. The original CMI approach is deterministic, however, in this paper we make it stochastic using techniques outlined by Koller and described by Browne et al. Comparing our results with a pure extrapolative approach, we find that the CMI Mortality Projections Model is more suitable for long-term projections for China.
What Factors Moderate Self-Other Discrepancies in Decision Making? Results from a Vaccination Scenario
Authors: Petrova Dafina , Garcia-Retamero Rocio , van der Pligt Joop 
Published: September 2016

AbstractWhen we make risky decisions for others, we tend to follow social norms about risks. This often results in making different decisions for others than we would make for ourselves in a similar situation (i.e., self-other discrepancies). In an experiment, we investigated self-other discrepancies in young adults’ decisions to purchase a vaccine against a sexually-transmitted virus for themselves or for another person (i.e., the target of the decision). When the target’s preferences were in line with social norms, surrogates showed large self-other discrepancies in line with these norms. When the target’s preferences were contrary to social norms, surrogates did not show self-other discrepancies in line with these preferences; instead they still followed social norms,F(1, 140) = 21.45,p <.001, ηp2= .13. Surrogates with lower numeracy,F(2, 128) = 3.44,p =.035, ηp2= .05, and higher empathy,F(2, 128) = 3.72,p =.027, ηp2= .06, showed self-other discrepancies more in line with the target’s preferences, even when these were contrary to the norm. Surrogates whose own risk attitudes were contrary to social norms showed larger self-other discrepancies,F(1, 128) = 5.38,p =.022, ηp2= .04. These results demonstrate that perceived social norms about risk can predict self-other discrepancies in risky decisions, even when the target’s preferences are known and at odds with the social norm. Further, the surrogates’ numeracy, empathy, and propensity to take risks influence the extent to which risky decisions for others resemble risky decisions for oneself.
Impact of Participation in Decision Making on Job Satisfaction: An Organizational Communication Perspective
Authors: Xia Ying , Zhang Li , Zhao Ning 
Published: September 2016

AbstractParticipation in organizational decision-making has received considerable attention from scholars. Beyond the perspectives proposed in past studies, we offer a new account, based upon a communication perspective, to explain why and when participation in decision-making can influence job satisfaction. Drawing from social capital theory, we examine whether communication openness mediates the relationship between participation in decision-making and job satisfaction. We also investigate how information adequacy moderates this mediated process. Results from a sample of 184 employees in China showed that the four-factor model was the best fitting solution (CFI = .91, GFI = .90, RMSEA = .09). The analyses indicated that employees’ participation in decision-making positively affected their job satisfaction (β = .32,p< .001), and the effect was mediated by communication openness (direct effect became non-significant when communication openness was included: β = .06,n.s.). Results also found that decision-making information adequacy positively moderated the relationship between participation in decision-making and communication openness (β = .13,p< .05). Thus, open communication and the free flow of information within organizations should be encouraged.
Bone–cartilage crosstalk: a conversation for understanding osteoarthritis
Authors: Findlay David M , Kuliwaba Julia S 
Published: September 2016

AbstractAlthough cartilage degradation is the characteristic feature of osteoarthritis (OA), it is now recognized that the whole joint is involved in the progression of OA. In particular, the interaction (crosstalk) between cartilage and subchondral bone is thought to be a central feature of this process. The interface between articular cartilage and bone of articulating long bones is a unique zone, which comprises articular cartilage, below which is the calcified cartilage sitting on and intercalated into the subchondral bone plate. Below the subchondral plate is the trabecular bone at the end of the respective long bones. In OA, there are well-described progressive destructive changes in the articular cartilage, which parallel characteristic changes in the underlying bone. This review examines the evidence that biochemical and biomechanical signaling between these tissue compartments is important in OA disease progression and asks whether such signaling might provide possibilities for therapeutic intervention to halt or slow disease development.
Interleukin-15 promotes intestinal dysbiosis with butyrate deficiency associated with increased susceptibility to colitis
Authors: Meisel Marlies , Mayassi Toufic , Fehlner-Peach Hannah , Koval Jason C , O’Brien Sarah L , Hinterleitner Reinhard , Lesko Kathryn , Kim Sangman , Bouziat Romain , Chen Li , Weber Christopher R , Mazmanian Sarkis K , Jabri Bana , Antonopoulos Dionysios A 
Published: September 2016

Abstract
Dysbiosis resulting in gut-microbiome alterations with reduced butyrate production are thought to disrupt intestinal immune homeostasis and promote complex immune disorders. However, whether and how dysbiosis develops before the onset of overt pathology remains poorly defined. Interleukin-15 (IL-15) is upregulated in distressed tissue and its overexpression is thought to predispose susceptible individuals to and have a role in the pathogenesis of celiac disease and inflammatory bowel disease (IBD). Although the immunological roles of IL-15 have been largely studied, its potential impact on the microbiota remains unexplored. Analysis of 16S ribosomal RNA-based inventories of bacterial communities in mice overexpressing IL-15 in the intestinal epithelium (villin-IL-15 transgenic (v-IL-15tg) mice) shows distinct changes in the composition of the intestinal bacteria. Although some alterations are specific to individual intestinal compartments, others are found across the ileum, cecum and feces. In particular, IL-15 overexpression restructures the composition of the microbiota with a decrease in butyrate-producing bacteria that is associated with a reduction in luminal butyrate levels across all intestinal compartments. Fecal microbiota transplant experiments of wild-type and v-IL-15tg microbiota into germ-free mice further indicate that diminishing butyrate concentration observed in the intestinal lumen of v-IL-15tg mice is the result of intrinsic alterations in the microbiota induced by IL-15. This reconfiguration of the microbiota is associated with increased susceptibility to dextran sodium sulfate-induced colitis. Altogether, this study reveals that IL-15 impacts butyrate-producing bacteria and lowers butyrate levels in the absence of overt pathology, which represent events that precede and promote intestinal inflammatory diseases.
A dendritic disinhibitory circuit mechanism for pathway-specific gating
Authors: Yang Guangyu Robert , Murray John D. , Wang Xiao-Jing 
Published: September 2016

AbstractWhile reading a book in a noisy café, how does your brain ‘gate in’ visual information while filtering out auditory stimuli? Here we propose a mechanism for such flexible routing of information flow in a complex brain network (pathway-specific gating), tested using a network model of pyramidal neurons and three classes of interneurons with connection probabilities constrained by data. We find that if inputs from different pathways cluster on a pyramidal neuron dendrite, a pathway can be gated-on by a disinhibitory circuit motif. The branch-specific disinhibition can be achieved despite dense interneuronal connectivity, even with random connections. Moreover, clustering of input pathways on dendrites can naturally emerge through synaptic plasticity regulated by dendritic inhibition. This gating mechanism in a neural circuit is further demonstrated by performing a context-dependent decision-making task. The model suggests that cognitive flexibility engages top-down signalling of behavioural rule or context that targets specific classes of inhibitory neurons.