bluuebunny/crossref_metadata_2025_split huggingface dataset:
Love, Lust, Life and Landscape
Authors: Muller Vivienne 
Published: August 2016

Brisbane is the kind of city that if it did not exist would have to be invented — and indeed it has by many of its writers. Its history of settlement and its political conservatism of the slash, burn and bulldoze variety has urged writers like Sam Watson in his novel The Kadaitcha Sung to depict it as a place of punishment, violence, racism and red-necked parochialism. The same sense of oppression informs David Malouf's mixed nostalgic references to the city as a place of beauty and boredom, a city you can love and hate in Johnno. In similar vein, Jessica Anderson in Tirra Lirra by the River, Angelika Fremd in The Glass Inferno and Janette Turner Hospital in both short stories and novels, depict Brisbane as a place one needs to leave but also a place where epiphanies are possible, and where the past haunts the present with a ferocious insistence. For novelists Rosie Scott, Janette Turner Hospital and Venero Armanno, Brisbane is simultaneously Paradise Lost and Paradise Regained. Many writers depict Brisbane as a great place to grow up in but you wouldn't want to live there — unless you are Hugh Lunn. Brisbane has been, and arguably still is by some writers, seen both favourably and unfavourably as a provincial backwater, unsophisticated and straight — still a frontier town in the popular and literary imagination if not in reality, a place where it is likely that you will know somebody who knows somebody you know. This is pointed out repeatedly by John Birmingham, author of the whimsical He Died With a Felafel in his Hand, by way of a distinguishing feature of flat life in Brisbane in contrast to other (Southern) capitals. In Brisbane, Birmingham writes:

Everyone's stories intersect, crossing over and through each other like sticky strands of destiny and DNA. (Birmingham, 42)
Rural Reading or Reading the Rural
Authors: Cryle Denis , Cosgrove Betty 
Published: August 2016

This article derives from an ongoing project to map regional print culture in twentieth-century Queensland. An essentially qualitative methodology combined survey questionnaires with selected follow-up interviews. Conscious of the focus on metropolitan reading within existing Australia Council studies (1990, 1995), we were keen to explore issues of cultural consumption, distribution, exchange and community identity in a regional context. Subsequently, however, we interrogated the notion of regionality itself and identified a reading sub-group within the larger sample of fifty responses, living outside larger regional centres like Rockhampton and Townsville. The study documents and explores reading patterns of this rural group whose experiences can all too easily be subsumed within the broader ‘regional’ category. Lyons' and Taksa's valuable study of New South Wales, Australian Readers Remember, makes this assumption, admitting to ‘a definite bias in favour of Sydney at the expense of country districts’ while acknowledging that ‘cultural attitudes differ in rural environments’ (1992: 22–23).
Can Brisbane Remain a Subtropical City?
Authors: Spearritt Peter 
Published: August 2016

'As the seasons change, public and private gardens become a riot of colour. Winter shows the scarlet flags of poinsettia – Brisbane's emblem, which, if really a Mexican beauty, has made itself very much at home. The lavender glow of jacaranda and the gold of laburnum, the green umbrella of poinciana crowned with gleaming scarlet, the massed magnificence of magenta bougainvillea, the creamy blossoms and heavy tropical scent of frangipani filling the air with sweetness, the glare of cannas, the pink and white of bauhinia, the old-gold feathers of silky oak and the red and green of hibiscus – these are but a few of the array of colours.'
C. C. D. Brammall

Brisbane has been relentlessly cleared since the first British soldiers and convicts set up at Redcliffe and then moved to the site we know as Brisbane today. As in other Australian colonies the new settlers were keen to grow crops and to exploit the timber both as a building material and later as a rich source of export income. While early explorers and botanists recorded the richness of the vegetation most new settlers saw the landscape as a resource to be exploited, not a pristine environment to be treated with respect.
'The Mighty Byronian Olympus'
Authors: Taylor Cheryl 
Published: August 2016

Archibald Meston (b. 1851) is remembered as the framer in Queensland of the 1897 Aboriginal Protection Act, legislation which he later helped to implement as Southern Protector. From 1870 until his death in 1924, he published hundreds of articles, stories, poems and letters in Queensland and New South Wales newspapers. While by no means distinguished as literature, this mass of material invites attention not only for its diverse discourses on Indigenous people, but also because it helped to shape the idea of Queensland held by residents and outsiders. The state's history, natural history and geography are Meston's most frequent subjects. This essay seeks to understand further the ideological significance of his journalistic construction of Queensland by examining the connections cultivated in his writings with the poetry of the Romantics, Byron and Shelley, and their American successors, Longfellow and Poe.
Transformative Moments
Authors: McKay Belinda 
Published: August 2016

Janette Turner Hospital is the author of eight novels, four collections of short stories, a novella published only in French, and a crime thriller under the pseudonym Alex Juniper. Her work has been published in 20 countries, and in 12 languages other than English. She is the recipient of a number of overseas literary awards, and both Griffith University (in 1996) and the University of Queensland (in 2003) have conferred honorary doctorates upon her. In 2003 she won the Queensland Premier's Literary Award for Best Fiction Book for her most recent novel, Due Preparations for the Plague, and the Patrick White Award for Lifetime Literary Achievement.
100 Years of Women's Suffrage in Queensland 1905–2005
Authors: McCulloch John 
Published: August 2016

The year 2005 is an important one for Queensland women for three reasons. It is the centenary of women getting the vote (25 January 1905). It is the 90th anniversary of women getting the right to stand for Parliament (23 November 1915). Finally, it is the 76th anniversary of the first woman being elected to the Queensland Parliament (11 May 1929).
The Leisure Pursuits of Brisbane Children During the 1930s Depression
Authors: Leach Carolyn 
Published: August 2016

Over the last 30 years, many books have appeared on different aspects of childhood in Australia. There has not, however, been an authoritative published history of childhood that is specific to the Depression years. Sue Fabian and Morag Loh's Children in Australia: An Outline History and Jan Kociumbas's Australian Childhood: A History include chapters that offer overviews of Australian childhood during the Depression, and Lynette Finch's special issue of Queensland Review, Young in a Warm Climate, is the only major study specific to children in Queensland. This paper makes a contribution to Queensland Depression historiography and the history of Queensland children by exploring how the children of Brisbane's working-class unemployed spent their leisure hours, and what effect — if any — the Depression exerted over the choices that were made. It will show mat there was neither uniformity of experience nor a sharp discontinuity between the Depression years and those that preceded and followed this decade.
David Malouf, 'Typewriter Music', St Lucia: University of Queensland Press, 2007, 85 pp, ISBN 9 7807 0223 6310, $29.95. - David Malouf, 'Revolving Days', St Lucia: University of Queensland Press, 2008, 198 pp, ISBN 9 7807 0223 6358, $26.95
Authors: Buckridge Patrick 
Published: August 2016

David Malouf, Typewriter Music, St Lucia: University of Queensland Press, 2007, 85 pp, ISBN 9 7807 0223 6310, $29.95
David Malouf, Revolving Days, St Lucia: University of Queensland Press, 2008, 198 pp, ISBN 9 7807 0223 6358, $26.95
Bronwyn Lea, 'The Other Way Out'. Sydney: Giramondo, 2008, ISBN 978 1 920882 48 8, 96 pp, A$22.00
Authors: Neilsen Philip 
Published: August 2016

Bronwyn Lea, The Other Way Out, Sydney: Giramondo, 2008, ISBN 978 1 920882 48 8, 96 pp, A$22.00
Building the Queenslander
Authors: Symes Colin 
Published: August 2016

The material practices of school, as they relate to the child, have not figured prominently in the repertoire of educational inquiry. They have been examined only in so far that their understanding might result in optimising the conditions of learning or provide systematic explanations as to why school processes are inadequate. Any idea that the practices themselves might encode and instantiate visions of childhood and pedagogy contingent on broader schemes of social planning and ideas of the public good, does not appear to have entered the purview of those writing about education. Under the impact of the nouvelle histoire of Philippe Ariès and Michel Foucault, this situation is being redressed and there is an evolving body of literature devoted to the genealogy of classroom practice, with a specific focus on its origins and underpinning logics. Of special significance to such practice is the venue in which it takes place, namely, the school, which is a specialised form of architecture, housing a range of furnishings and facilities designed to enhance the positions of teacher and child in such a way as to advance the cause of education.
Coding Desire
Authors: Smaal Yorick 
Published: August 2016

Dropsy is a puff. It is not the first time he has done it. I can bring a witness who will swear that he got ten bob from a black fellow that stuffed him. I knew what he wanted when he went up the stairs so I followed him … there are plenty of others in Brisbane who do it besides us mob, so I am not the first.
— Conversation between Albert McNamara and Police Constable Lipp, Brisbane, 1905
Writing from the Hinterland
Authors: McKay Belinda 
Published: August 2016

Eleanor Dark's years in Montville represent an unusual moment in the history of Queensland literature: it was one of the rare instances, until recent times, of an established professional writer moving to Queensland and pursuing her career in a small rural community. Since the 1980s, the Sunshine Coast and its hinterland have become something of a mecca for writers. None of the later arrivals, however, has pursued Dark's project of viewing the wider world from the hinterland. In Lantana Lane she intertwines meticulous observation of local life, in which she participated as a farmer, with wider cultural and political concerns. She transforms the apparently inauspicious location of the hinterland into a vantage point from which to reflect on modes of production, from the agricultural to the literary.
Maternal micronutrient consumption periconceptionally and during pregnancy: a prospective cohort study
Authors: Livock Michelle , Anderson Peter J , Lewis Sharon , Bowden Stephen , Muggli Evelyne , Halliday Jane 
Published: August 2016

AbstractObjectiveTo examine overall micronutrient intake periconceptionally and throughout pregnancy in a population-based cohort of Australian women.DesignIn a prospective cohort study, micronutrient dosages were extracted from self-reported maternal supplement use, recorded pre-conception, and for each trimester of pregnancy. A food frequency scale (DQESv2) captured usual maternal diet for gestational weeks 14–26. The influence of sociodemographic and lifestyle factors associated with supplement use was examined using logistic regression, and changes in micronutrient intakes prior to and throughout pregnancy were assessed using repeated-measures ANOVA analyses.SettingMetropolitan hospital sites in Melbourne, Australia.SubjectsWomen with a viable singleton pregnancy were recruited at less than 19 weeks’ gestation (n2146).ResultsCompared with non-users, women using supplements during pregnancy were more likely to have planned their pregnancy, be >25 years old, primiparous, Caucasian, non-smokers, have a tertiary education and be consuming a folate-rich diet. Intakes of folate, Fe and Zn were significantly lower in the periconceptional period, compared with other periods (P<0·001). Intakes below Recommended Daily Intake levels were common both periconceptionally and throughout pregnancy, with 19–46 % of women not meeting the Recommended Daily Intake for folate, 68–82 % for Fe and 17–36 % for Zn. Conversely, 15–19 % of women consumed beyond the recommended Upper Limit for folate and 11–24 % for Fe.ConclusionsThe study highlights the need for improved public health education on nutritional needs during pregnancy, especially among women with lower educational achievements and income.
MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
Authors: Moretti Irene , Ciciliot Stefano , Dyar Kenneth A. , Abraham Reimar , Murgia Marta , Agatea Lisa , Akimoto Takayuki , Bicciato Silvio , Forcato Mattia , Pierre Philippe , Uhlenhaut N. Henriette , Rigby Peter W. J. , Carvajal Jaime J. , Blaauw Bert , Calabria Elisa , Schiaffino Stefano 
Published: August 2016

AbstractThe myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy. This effect is accompanied by increased protein synthesis and widespread activation of muscle-specific genes, many of which are targets of MEF2 transcription factors. MEF2-dependent genes represent the top-ranking gene set enriched after Mrf4 RNAi and a MEF2 reporter is inhibited by co-transfected MRF4 and activated by Mrf4 RNAi. The Mrf4 RNAi-dependent increase in fibre size is prevented by dominant negative MEF2, while constitutively active MEF2 is able to induce myofibre hypertrophy. The nuclear localization of the MEF2 corepressor HDAC4 is impaired by Mrf4 knockdown, suggesting that MRF4 acts by stabilizing a repressor complex that controls MEF2 activity. These findings open new perspectives in the search for therapeutic targets to prevent muscle wasting, in particular sarcopenia and cachexia.
High fat diet-induced TGF-β/Gbb signaling provokes insulin resistance through the tribbles expression
Authors: Hong Seung-Hyun , Kang Moonyoung , Lee Kyu-Sun , Yu Kweon 
Published: August 2016

AbstractHyperglycemia, hyperlipidemia, and insulin resistance are hallmarks of obesity-induced type 2 diabetes, which is often caused by a high-fat diet (HFD). However, the molecular mechanisms underlying HFD-induced insulin resistance have not been elucidated in detail. In this study, we established a Drosophila model to investigate the molecular mechanisms of HFD-induced diabetes. HFD model flies recapitulate mammalian diabetic phenotypes including elevated triglyceride and circulating glucose levels, as well as insulin resistance. Expression of glass bottom boat (gbb), a Drosophila homolog of mammalian transforming growth factor-β (TGF-β), is elevated under HFD conditions. Furthermore, overexpression of gbb in the fat body produced obese and insulin-resistant phenotypes similar to those of HFD-fed flies, whereas inhibition of Gbb signaling significantly ameliorated HFD-induced metabolic phenotypes. We also discovered that tribbles, a negative regulator of AKT, is a target gene of Gbb signaling in the fat body. Overexpression of tribbles in flies in the fat body phenocopied the metabolic defects associated with HFD conditions or Gbb overexpression, whereas tribbles knockdown rescued these metabolic phenotypes. These results indicate that HFD-induced TGF-β/Gbb signaling provokes insulin resistance by increasing tribbles expression.
Pre-Clinical Study of a Novel Recombinant Botulinum Neurotoxin Derivative Engineered for Improved Safety
Authors: Vazquez-Cintron Edwin , Tenezaca Luis , Angeles Christopher , Syngkon Aurelia , Liublinska Victoria , Ichtchenko Konstantin , Band Philip 
Published: August 2016

AbstractCyto-012 is a recombinant derivative of Botulinum neurotoxin Type A (BoNT/A). It primarily differs from wild type (wt) BoNT/A1 in that it incorporates two amino acid substitutions in the catalytic domain of the light chain (LC) metalloprotease (E224 > A and Y366 > A), designed to provide a safer clinical profile. Cyto-012 is specifically internalized into rat cortical and hippocampal neurons, and cleaves Synaptosomal-Associated Protein 25 (SNAP-25), the substrate of wt BoNT/A, but exhibits slower cleavage kinetics and therefore requires a higher absolute dose to exhibit pharmacologic activity. The pharmacodynamics of Cyto-012 and wt BoNT/A have similar onset and duration of action using the Digital Abduction Assay (DAS). Intramuscular LD50 values for Cyto-012 and wt BoNT/A respectively, were 0.63 ug (95% CI = 0.61, 0.66) and 6.22 pg (95% CI = 5.42, 7.02). ED50 values for Cyto-012 and wt BoNT/A were respectively, 0.030 ug (95% CI = 0.026, 0.034) and 0.592 pg (95% CI = 0.488, 0.696). The safety margin (intramuscular LD50/ED50 ratio) for Cyto-012 was found to be improved 2-fold relative to wt BoNT/A (p < 0.001). The DAS response to Cyto-012 was diminished when a second injection was administered 32 days after the first. These data suggest that the safety margin of BoNT/A can be improved by modulating their activity towards SNAP-25.
The Microbiome of Aseptically Collected Human Breast Tissue in Benign and Malignant Disease
Authors: Hieken Tina J. , Chen Jun , Hoskin Tanya L. , Walther-Antonio Marina , Johnson Stephen , Ramaker Sheri , Xiao Jian , Radisky Derek C. , Knutson Keith L. , Kalari Krishna R. , Yao Janet Z. , Baddour Larry M. , Chia Nicholas , Degnim Amy C. 
Published: August 2016

AbstractGlobally breast cancer is the leading cause of cancer death among women. The breast consists of epithelium, stroma and a mucosal immune system that make up a complex microenvironment. Growing awareness of the role of microbes in the microenvironment recently has led to a series of findings important for human health. The microbiome has been implicated in cancer development and progression at a variety of body sites including stomach, colon, liver, lung and skin. In this study, we assessed breast tissue microbial signatures in intraoperatively obtained samples using 16S rDNA hypervariable tag sequencing. Our results indicate a distinct breast tissue microbiome that is different from the microbiota of breast skin tissue, breast skin swabs and buccal swabs. Furthermore, we identify distinct microbial communities in breast tissues from women with cancer as compared to women with benign breast disease. Malignancy correlated with enrichment in taxa of lower abundance including the genera Fusobacterium, Atopobium, Gluconacetobacter, Hydrogenophaga and Lactobacillus. This work confirms the existence of a distinct breast microbiome and differences between the breast tissue microbiome in benign and malignant disease. These data provide a foundation for future investigation on the role of the breast microbiome in breast carcinogenesis and breast cancer prevention.
Frontotemporal dementia and language networks: cortical thickness reduction is driven by dyslexia susceptibility genes
Authors: Paternicó Donata , Manes Marta , Premi Enrico , Cosseddu Maura , Gazzina Stefano , Alberici Antonella , Archetti Silvana , Bonomi Elisa , Cotelli Maria Sofia , Cotelli Maria , Turla Marinella , Micheli Anna , Gasparotti Roberto , Padovani Alessandro , Borroni Barbara 
Published: August 2016

AbstractVariations within genes associated with dyslexia result in a language network vulnerability, and in patients with Frontotemporal Dementia (FTD), language disturbances represent a disease core feature. Here we explored whether variations within three related-dyslexia genes, namely KIAA0319, DCDC2, and CNTNAP, might affect cortical thickness measures in FTD patients. 112 FTD patients underwent clinical and neuropsychological examination, genetic analyses and brain Magnetic Resonance Imaging (MRI). KIAA0319 rs17243157 G/A, DCDC2 rs793842 A/G and CNTNAP2 rs17236239 A/G genetic variations were assessed. Cortical thickness was analysed by Freesurfer. Patients carrying KIAA0319 A*(AG or AA) carriers showed greater cortical thickness atrophy in the left fusiform and inferior temporal gyri, compared to KIAA0319 GG (p ≤ 0.001). Patients carrying CNTNAP2 G*(GA or GG) showed reduced cortical thickness in the left insula thenCNTNAP2 AA carriers (p≤0.001). When patients with both at-risk polymorphisms were considered (KIAA0319 A* and CNTNAP2 G*), greater and addictive cortical thickness atrophy of the left insula and the inferior temporal gyrus was demonstrated (p ≤ 0.001). No significant effect of DCDC2 was found. In FTD, variations of KIAA0319 and CNTNAP2 genes were related to cortical thickness abnormalities in those brain areas involved in language abilities. These findings shed light on genetic predisposition in defining phenotypic variability in FTD.
Composite alginate gels for tunable cellular microenvironment mechanics
Authors: Khavari Adele , Nydén Magnus , Weitz David A. , Ehrlicher Allen J. 
Published: August 2016

AbstractThe mechanics of the cellular microenvironment can be as critical as biochemistry in directing cell behavior. Many commonly utilized materials derived from extra-cellular-matrix create excellent scaffolds for cell growth, however, evaluating the relative mechanical and biochemical effects independently in 3D environments has been difficult in frequently used biopolymer matrices. Here we present 3D sodium alginate hydrogel microenvironments over a physiological range of stiffness (E = 1.85 to 5.29 kPa), with and without RGD binding sites or collagen fibers. We use confocal microscopy to measure the growth of multi-cellular aggregates (MCAs), of increasing metastatic potential in different elastic moduli of hydrogels, with and without binding factors. We find that the hydrogel stiffness regulates the growth and morphology of these cell clusters; MCAs grow larger and faster in the more rigid environments similar to cancerous breast tissue (E = 4–12 kPa) as compared to healthy tissue (E = 0.4–2 kpa). Adding binding factors from collagen and RGD peptides increases growth rates, and change maximum MCA sizes. These findings demonstrate the utility of these independently tunable mechanical/biochemistry gels, and that mechanical confinement in stiffer microenvironments may increase cell proliferation.
Control of fibrotic changes through the synergistic effects of anti-fibronectin antibody and an RGDS-tagged form of the same antibody
Authors: Tiwari Anil , Kumar Rajendra , Ram Jagat , Sharma Maryada , Luthra-Guptasarma Manni 
Published: August 2016

AbstractTGF-β and myofibroblasts play a key role in fibrosis, characterized by aberrant synthesis and deposition of extracellular matrix (ECM) proteins, such as fibronectin (Fn) and collagen type I. There are two major roles played by integrins in the fibrotic pathology: (i) Fn-integrin interaction, coupled with cytokines like TGF-β, facilitates the self-polymerization of Fn and regulates cell–matrix fibrillar adhesions, thereby promoting fibrillogenesis; (ii) Integrin interaction with an RGD (arginine-glycine–aspartic) consensus sequence in the latent TGF-β, resulting in its activation. This study describes an anti-fibrotic strategy using a combination of two antibodies: Fn52 (targeted against the N-terminal 30 kDa region of fibronectin, a major site for Fn self-association) and its engineered form, Fn52RGDS (which binds to integrins). Interestingly, a synergistic effect of the cocktail in causing a decline in fibrotic features was confirmed in the context of fibrotic posterior capsular opacification (PCO), mediated by the lens epithelial cells (left behind after cataract surgery). Inclusion of Fn52RGDS to Fn52 aids in better diffusion of the antibodies; such combination therapies could be useful in the context of pathologies involving extensive remodeling of the fibronectin matrix, where the thick ECM offers a major challenge for efficient drug delivery.