bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Subtypes Are Associated With Clinical Benefit in Cisplatin-Treated Metastatic Urothelial Cancer Patients
Authors: Holmsten Karin , Sjödahl Gottfrid , Abrahamsson Johan , Bernardo Carina , Eriksson Pontus , Höglund Mattias , Liedberg Fredrik , Ullén Anders 
Published: September 2024

PURPOSE
Cisplatin-based combination chemotherapy (CHT) is standard of care in metastatic urothelial cancer (mUC); however, no predictive molecular biomarkers are available for clinical use. The aim of this study was to investigate the impact of molecular subtypes in relation to treatment response and survival in patients with mUC treated with first-line CHT.

PATIENTS AND METHODS
Molecular subtype classification according to the Lund Taxonomy (LundTax) was performed by tumor transcriptomic profiling and immunostaining in a retrospective cohort. Molecular subtypes were investigated in relation to the primary end point overall response rate (ORR) and secondary end points progression-free survival (PFS) and overall survival (OS). Differential gene expression and association to treatment response were explored.

RESULTS

Ninety-five patients with mUC were classified into urothelial-like (Uro, 43%), genomically unstable (GU, 26%), basal squamous-like (Ba/Sq, 20%), mesenchymal-like (Mes-like, 8%), and small cell neuroendocrine-like (Sc/NE, 3%) subtypes. Patients with Mes-like tumors had lower ORR (14%) compared with Uro (70%), GU (77%), Ba/Sq (75%), and Sc/NE (67%; odds ratio, 0.06 [95% CI, 0.01 to 0.54],
P
= .012). Furthermore, patients with Mes-like tumors had significantly shorter PFS (hazard ratio [HR], 5.18 [95% CI, 2.28 to 11.76],
P
< .001) and OS (HR, 3.19 [95% CI, 1.45 to 7.03],
P
= .004). Patients with Uro and GU showed the longest survival. In responders, an enrichment of downregulated stromal- and immune-related genes was seen. Downregulation of interferon-induced transmembrane protein 2 was associated with increased ORR and improved OS.

CONCLUSION
This study identifies different CHT responses by LundTax molecular subtypes in patients with mUC, where the Mes-like subtype was associated with lower response rate and shorter survival.
Learning in Inverse Optimization: Incenter Cost, Augmented Suboptimality Loss, and Algorithms
Authors: Zattoni Scroccaro Pedro , Atasoy Bilge , Mohajerin Esfahani Peyman 
Published: September 2024

Enhancing the Efficiency and Accuracy of Inverse Optimization Inverse optimization (IO) is used to model the behavior of decision-making agents who solve optimization problems in response to external signals. Inspired by the geometry of IO problems, in “Learning in Inverse Optimization: Incenter Cost, Augmented Suboptimality Loss, and Algorithms,” Zattoni Scroccaro, Atasoy, and Mohajerin Esfahani propose the “incenter” concept to solve IO problems, which unlike previously proposed approaches, can be used to derive computationally tractable solutions to this modeling problem. Moreover, they also propose a novel loss function for IO problems and a tailored optimization algorithm to optimize it. Extensive numerical experiments showcase the improved efficiency and accuracy of the proposed IO formulations and algorithm.
Challenging and encouraging halal certification in handicraft MSMEs
Authors: Mamduh Muhammad Faiz , Saputra Deky Chandra , Pertiwi Soraya Noer , Widiastuti Tika 
Published: September 2024

Halal certification, a crucial aspect of the halal product industry in Indonesia, is mandatory for food and beverage products. However, awareness and understanding of halal certification remain low among Handicraft MSMEs (Micro, Small, and Medium Enterprises). This research explores the perceptions, understanding, awareness, and challenges Handicraft MSMEs face regarding halal certification. A qualitative approach with semi-structured interviews was employed as the data collection method, followed by NVivo software analysis. The results indicate that Handicraft MSMEs lack an understanding of the importance of halal certification and are unaware of the obligations and procedures involved. We identified insufficient socialization as a significant obstacle, underscoring the urgent need for more awareness campaigns and educational programs. The complexity of the certification process and lack of coordination among halal institutions are also significant obstacles. This research provides profound insights into the challenges and opportunities in implementing halal certification for Handicraft MSMEs, emphasizing the crucial role of the government in promoting and facilitating halal certification implementation for Handicraft MSMEs to support growth and competitiveness in the market.

Keywords: Halal certification, Handicraft MSMEs, NVivo
Analysis of the effect of fermentation duration on the organoleptic properties of dried cocoa beans (Theobroma cacao L.) at Nglanggeran Agricultural Technology Park
Authors: Permata Annisa , Hidayah Nurul 
Published: September 2024

The post-harvest process of cocoa fruits includes fruit harvesting, cracking, wet bean sorting, fermentation, drying, dry bean sorting, and packaging. One of the post-harvest processes that significantly affects the quality of cocoa beans is fermentation. The fermentation process, facilitated by acetic acid and lactic acid bacteria, aims to reduce moisture content, enhance aroma and flavor, and improve the quality of cocoa beans. Acetic acid bacteria, such as Acetobacter and Gluconobacter, contribute to acetic acid production, giving cocoa beans their characteristic flavor. These bacteria convert alcohol into acetic acid, a process crucial for developing the beans' flavor. On the other hand, lactic acid bacteria, like Lactobacillus and Pediococcus, play a role in the breakdown of complex compounds, enhancing the aroma. These bacteria produce lactic acid, which contributes to the beans' aroma. One factor that influences the success of cocoa fruit fermentation is the duration of fermentation. The optimal fermentation time for cocoa fruits is 5 – 6 days. If it is less or exceeds the optimal time, the fermentation of cocoa fruits will not be perfect. The duration of cocoa fruit fermentation has been proven to affect the aroma, taste, texture, and color of dried cocoa beans.

Keywords: Cocoa, Fermentation, Post-harvest process of cocoa, Organoleptic
Effect Iron Oxide (Fe2O3) nanoparticles synthesis by Teucrium polium L. on Cryptococcus neformans isolated from environmental sources in Kirkuk city, Iraq
Authors: Abbood Hussein Abdulrazzaq , Zainalabden Salah Salman 
Published: September 2024

This study isolated 60 samples from various locations in Kirkuk, including areas with high numbers of pigeons, and birds, residential backyards where chicken breeding takes place, and chicken selling markets where positive samples for Cryptococcus neoformans were identified. Five antifungals were used in different concentrations (Ketoconazole, Griseofulvin, Fluconazole, Nystatin, Clotrimazole), (0.02 g/mL, 0.04 g/mL, and 0.06 g/mL) the sensitivity of the drug to the spread method against isolates of the Cryptococcus neformans. The results showed that the fungal isolates were sensitive to antifungals. This study showed that nystatin has a greater inhibitory ability and a broad spectrum of activity than other antifungals, while griseofulvin did not show any inhibitory ability. Iron oxide nanoparticles (Fe2O3 NPs) are produced by the Teucrium polium L. extract as a reducing agent. We used an X-ray diffraction analysis and an SEM to confirm if these nano-oxides were present. The antifungal properties of Fe2O3 NPs against Cryptococcus neformans were investigated by the well diffusion method. With the increase in concentration of (Fe2O3 NPs). The diameter of inhibition growth zones of the fungal strains became greater; the Cryptococcus neformans growth inhibition zone was 32. 6 ± 0.6 mm, 31.2 ± 0.6 mm, 26 ± 0.5 mm, 24. 4 ± 0.4 mm and 21 ± 0.3 mm and 17.1 ± 0.0 for concentrations 6 mg/mL, 5 mg/mL, 4 mg/mL, 3 mg/mL, 2 mg/mL and 1 mg/mL respectively. Thus, we can conclude that the concentration of the solution of nanoparticles and antifungals directly affects the ability to inhibit the growth of fungi.
Broadcasting Umrah through the Hadith of Hajj Badal in the COVID-19 Pandemic Era.
Authors: Dewi Subkhani Kusuma , Akmaluddin Muhammad 
Published: September 2024

This article delves into an extensive project concerning the development of the umrah industry in Indonesia and its relationship with the interpretation of Hadith. Specifically, it examines the impact of the pandemic on this brief pilgrimage practice in Indonesia, a predominantly Muslim society. Despite the economic setbacks, the pandemic has significantly influenced the widespread use of social media globally. Indonesian Muslims, being active netizens, have shown a strong desire to reconnect with the sacred sites in Mecca and Medina. This article employs a multifaceted approach to investigate the utilization of social media by Indonesian muṭawwifs-vloggers, employing intersecting methodologies. Firstly, it conducts a textual study focusing on thematic badal Umrah. Secondly, it involves (online) observations and participation in the activities of various muṭawwifs vloggers based in Saudi Arabia. The result of this research is that cyber-mediated Umrah experiences cannot fully substitute the physical pilgrimage journey. Badal Umrah, primarily rooted in the badal Hajj Hadiths. It emerges as a crucial practice during times of crises and being used as legitimacy inoffering assistance to those who are physically unable to undertake the journey. Consequently, there has been an increased acceptance of Hadiths related to Hajj and Umrah during the pandemic, ." In addition, Muṭawwifs play a pivotal role in facilitating communication between i forced mobility of aspiring pilgrims during the pandemic, thereby emphasizing the importance of ethical considerations. Lastly, the activities in the cyber-space realm align with three essential dimensions: providing an imaginative travel experience for dispersed audiences, engaging muṭawwifs as navigators in the cyber-space, and addressing ethical considerations concerning badal Umrah amidst health and financial challenges.
Revisiting The Critical Edition of the Qur'an: Historical Perspectives and Contemporary Challenges
Authors: Khusna Farida  
Published: September 2024

The concept of a critical edition of the Qur'an resurfaced following earlier attempts by western scholars such as Bergstresser (w. 1351 AH/1933 AD), Jeffery (w. 1378 AH/1959 AD), and Pretzl (w. 1360 AH/1941 AD), who were supported by Fischer (w. 1369 H/1949 M), Baumstark (w. 1368 AH/1948 AD), Ritter (w. 1391 AH/1971 AD), and Kahle (w. 1384 AH/1964 AD). In a conference at the University of Notre Dame in April 2005, Gabriel Said Reynolds proposed “The New Reading of the Qur`an” for updating textual reseacrh on the Qur`an, after various manuscripts were discovered as research material for the Qur`an. Additionally, among those who contributed to the conceptualization of the Critical Edition of the Qur'ān is Taufik Adnan Amal, a Muslim scholar. This qualitative-historical research, I examine the ideas of the Bergstresser, Jeffery, dan Pretzl’s version of the Critical Edition of the Qur`a and Taufik Adnan Amal’s version to find out whether both of them are same or different. As well, this study aims to answer the possibility of the existence of a contemporary Critical Edition of the Qur'an as implied by both of them. Even though they use the same term, their Critical Edition of Quran do not only have similarities, but also have differences. As for the possibility of using the ikhtiyâr technique at the present time to produce a Critical Edition for the Qur`an, many factors must be considered and should comply with the conditions that apply. One of them, if it is still possible, there are maqbûl readings outside the ten. The reciters who perform ikhtiyâr must also have a sanadreaching to Rasulullah saw.
Potensi Minyak Bumi Indonesia di Laut Timor dalam Rangka Pencarian Sumber Energi Alternatif
Authors: Tais Muhammad Sultan Audi , Dyota Demetrius , Shebahi Fikky Itsbatul Waqiey Esh , Yulianti Dina , Sari Deasy Silvya 
Published: September 2024

Indonesia sebagai negara kepulauan memiliki perairan yang sangat luas, oleh karenanya minyak dan gas yang ada di dasar laut di belum sepenuhnya dieksplorasi. Saat ini Indonesia masih banyak melakukan impor minyak bumi dari negara tetangga, dan Indonesia mengalami penurunan cadangan minyak dari tahun ke tahun. Sehingga pengelolaan minyak bumi perlu lebih ditingkatkan lagi agar selaras dengan blue economy. Blue economy memiliki tujuan untuk menciptakan pertumbuhan ekonomi yang memaksimalkan pengelolaan laut. Laut Timor menjadi wilayah yang kaya akan minyaknya namun belum dieksplorasi sepenuhnya. Eksplorasi dan pemanfaatan migas di laut dapat menjadi salah satu cara bagi Indonesia untuk memenuhi kebutuhan energi yang kian meningkat. Penelitian ini merupakan penelitian kualitatif yang bertujuan untuk menjelaskan bagaimana migas di Laut Timor dapat menjadi salah satu sektor penting bagi blue economy indonesia. Penelitian ini diteliti memakai konsep keamanan energi, terutama 4A dari keamanan energi (availability, accessibility, acceptability dan affordability). Hasil dari penelitian ini menunjukkan bahwa minyak bumi Indonesia di wilayah Laut Timor belum tereksploitasi sepenuhnya, dimana melalui 4A keamanan energi, potensi minyak bumi di Laut Timor tersebut jika dapat dikelola dengan optimal dapat meningkatkan keamanan energi Indonesia dalam jangka panjang.
Molecular docking analysis of subtilisin-like alkaline serine protease (SLASP) and laccase with natural biopolymers
Authors: Narayanaswamy Radhakrishnan , Prabhakaran Vasantha-Srinivasan , Al-Otibi Fatimah Oleyan , Alharbi Raedah Ibrahim , Ibrahim Kalibulla Syed 
Published: September 2024

Abstract
Alkaline serine proteases (ASPs) and laccases (Lacs) have been reported to possess several industrial applications, particularly in the food, cosmetic, and leather industries. Thus, in the present study, eighteen natural biopolymers, including agar, agarose, alginate, kappa carrageenan, cellulose, chitosan pentamer, chitosan oligosaccharide, chondroitin sulfate, dextran, fucoidan, heparin, hyaluronan, lignin, mannan, pectin, phytic acid, pullulan and starch soluble, were studied for their docking behavior, such as subtilisin-like alkaline serine protease (SLASP) KP-43 and Bacillus subtilis laccase (Bs Lac), using the SwissDock method. Additionally, the toxicity toward honey bees and human liver was determined by utilizing the free Bee-Tox and pkCSM web servers, respectively. Bee-Tox analysis demonstrated that four ligands (namely, agar, cellulose, lignin, and pullulan) exhibited acute oral toxicity toward honey bees (Apis mellifera). The docking study revealed that chitosan pentamer and lignin exhibited maximum binding energies of −9.67 and −11.37 kcal/mol against the target proteins SLASP (KP-43) and Lac (Bs Lac), respectively. Interestingly, in the present study, agarose was shown to interact with the His68 and Ser255 amino acid residues of SLASP (KP-43) from KSM-KP43 Bacillus sp. Thus, the current investigation showed the potential of eighteen natural biopolymers as immobilizing agents to prepare ASP and Lac nanoparticles for biomedical applications.
Experiences of Adult Learners Engaged in Blended Learning beyond COVID-19 in Ghana
Authors: Biney Isaac Kofi , Azaglo Janet 
Published: September 2024

Abstract
The COVID-19 pandemic has transformed the educational landscape, making exploration of blended learning (BL) instructional delivery important. Higher education institutions are navigating the effects of the COVID-19 crisis on instructional delivery. Using Accra Learning Centre as a case study, this article explores the experiences of adult learners engaged in BL after the COVID-19 crisis in Ghana. A qualitative research method was employed, and a purposive sampling procedure was used to select 15 adult learners. An in-depth interview guide was developed to garner data. Thematic, narrative, and interpretivist analytical approaches were adopted in presenting the results. Participants’ voices, experiences, and meanings were sought. It emerged that BL promotes inquiry-based, self-directed, and constructivist learning rather than using conventional face-to-face teaching and learning, though conventional teaching and learning cannot be discounted, BL fosters self-paced learning among adult learners. It recommends that faculty continue to sharpen their skills in BL instructional delivery and adult learners should be equipped with skills in time management, and effective digital tools used to engage in BL.
Experimental studies on insulating oils for power transformer applications
Authors: Khandai Sujit , D. Jasper , Roy Nirmal K. 
Published: September 2024

Abstract
In recent days, ester-based alternatives like natural and synthetic oils are preferred as an alternative to mineral oil by the power industry due to its higher bio-degradability, superior thermal conductivity, and fire resistance than mineral oil. In addition to this, blended oils are quite attractive because of its low dielectric loss and a low ratio of degradation. The present research deals with the experimental studies on different insulating oils like mineral oil, synthetic ester oil, coconut oil, blended oils, and nanofluids, which are developed from ZnO and TiO2 nanoparticle doped at 0.01 vol% in different insulating oils through ultrasonication process. In this experiment, the critical properties like electrical and physicochemical properties are examined according to International Electrotechnical Commission and American Society for Testing and Materials standards. Results show that ZnO and TiO2 nano-powder enhances the AC breakdown voltage (BDV), dielectric permittivity, and DC resistivity properties of different insulating oils with improved flash and fire resistance. Remarkably, it is found that mineral oil-based TiO2 nanofluid shows an enhancement of 55.8 % in AC BDV, 9.1 % in permittivity, and 15 % in flash resistance. Moreover, mineral oil based ZnO and TiO2 nanofluid results exhibit remarkable decrement in loss tangent with increased DC resistance property. Finally, it is observed that the influence of TiO2 nano-powder at 0.01 vol% remarkably enhances the electrical and physicochemical properties in different insulating oils compared to ZnO nanofluids. Hence, mineral oil and green insulating based synthetic ester oil (which is based on TiO2 nanofluids) have been considered as a potential candidate to make alternatives to traditional insulating oil for power transformer applications. The findings offer critical insights for the future of transformer insulation systems, guiding industry standards and fostering innovation in material science.
The crystal structure of (E)-1-phenyl-3-(p-tolylthio)but-2-en-1-one, C17H16OS
Authors: Tang Jinpeng , Wang Cheng , Long Xiang , Wu Xiongwei , Zhu Xiaoming , Zhang Fuxing 
Published: September 2024

Abstract
C17H16OS, monoclinic, P21/n (no. 14), a = 5.4605(12) Å, b = 19.767(4) Å, c = 13.357(4) Å, β = 92.834(3)°, V = 1,439.9(6) Å3, Z = 4, R
gt(F) = 0.0398, wR
ref(F
2) = 0.1144, T = 296(2) K.
REGIONAL COMPETITIVENESS THROUGH THE LENS OF REGIONAL ECONOMIC INDICATORS (Case Study of Nizhny Novgorod Oblast)
Authors: Яковлева П.Э. , Корнилова Ю.С. 
Published: September 2024

В статье представлен комплексный подход к оценке уровня конкурен­тоспособности региона. Приведены основные концепции оценки конку­рентоспособности. На основе их обобщения был сформулирован подход к анализу, предполагающий применение коэффициентов локализации, анализ структурных сдвигов и оценку открытости экономики региона путем расчета коэффициентов ввоза, вывоза и товарообмена. С по­мощью этих методов определяются преимущества региона, которые могут стать основой для улучшения его экономического состояния, по­скольку обладая точными характеристиками региональной экономики, зная ее сильные стороны и уязвимые места, можно построить намного более точный сценарий дальнейшего развития региона. В качестве при­мера для апробирования подхода была выбрана Нижегородская область. Результаты применения комплексного подхода были сопоставлены с по­казателями экономического положения Нижегородской области в ряде рейтингов. В итоге комплексный анализ конкурентных преимуществ од­ного региона Российской Федерации позволил определить его флагман­ские отрасли и потенциальные сферы развития.
The article presents a comprehensive approach to assessing the level of regional competitiveness. It outlines the main concepts of competitiveness assessment, leading to an approach that involves the use of localization coef­ficients, the analysis of structural shifts, and the evaluation of the openness of the regional economy by calculating import, export, and commodity exchange coefficients. These methods help identify the region’s advantages, which can serve as a foundation for improving its economic condition, because with accurate characteristics of the regional economy and knowing its strengths and vulnerabilities, it is possible to draw up a more precise deve­lopment scenario for the region. Nizhny Novgorod Oblast was chosen as a case study to test this approach. The integrated approach results have been com­pared with the economic position indicators of Nizhny Novgorod Oblast in several rankings. Consequently, this comprehensive analysis of the competi­tive advantages of one region in the Russian Federation enables the identi­fication of its flagship industries and potential areas for development.
Development and validation of RP-HPLC method with UV-DAD detection for simultaneous determination of acesulfame K, sodium saccharin and aspartame in beverages
Authors: Jankulovska Mirjana S. , Josimovska Teodora , Velkoska-Markovska Lenche 
Published: September 2024

AbstractArtificial sweeteners are low-calorie substances used as food additives with aim to impart a sweet taste to beverages without adding significant calories. Due to the regulatory compliance regarding the type and the amount of artificial sweetener, and due to the large consumption of beverages and the effects of artificial sweeteners on human health, their identification and quantification is of a great importance. In this research simultaneous determination of acesulfame K (ACE-K), sodium saccharin (Na-SAC) and aspartame (ASP) as the most commonly used sweeteners in beverages was performed with a reversed – phase high performance liquid chromatography (RP – HPLC) with diode array detection (DAD). The best separation of the analytes was achieved on a Poroshell 120 EC-C18 (3.0 × 50 mm, 2.7 µm) column and isocratic elution with a mobile phase consisted of acetonitrile and diluted phosphoric acid (pH = 3.8) with 7/93 volume ratio (V/V), and flow rate of 1 mL min−1. The chromatographic process was followed at 195, 220 and 230 nm, under constant column temperature (25 °C). Under these chromatographic conditions, the total time of analysis was less than 5 min. The developed method was validated for linearity, precision, accuracy, limit of detection (LOD) and limit of quantification (LOQ). The LOD under established chromatographic conditions was 0.03, 0.07 and 0.17 mg L−1 for Na-SAC, ACE-K and ASP, respectively. The amount of artificial sweeteners in analyzed samples ranged from 30.32 to 148.37 mg L−1 for ACE-K, from 16.10 to 93.05 for Na-SAC, and from 6.06 to 512.72 for ASP. The validated method was successfully applied for determination of analytes in different commercially available beverages.