bluuebunny/crossref_metadata_2025_split huggingface dataset:
Address‐Based Sampling for Recruiting Rural Subpopulations: A 2‐Phase, Multimode Approach
Authors: Thomson Tiffany L. , Nemeth Julianna M. , Peng Juan , Lu Bo , Ferketich Amy K. , Paskett Electra D. , Wewers Mary Ellen 
Published: July 2017

AbstractPurposeThis article describes recruitment of a subpopulation of women in a rural area, extending an existing method of a 2‐phase address‐based sampling protocol to include a mixed‐mode approach.MethodsPhase 1 included a household enumeration questionnaire mailed to randomly selected households (n = 1,950) in 3 Ohio Appalachian counties to identify members of the eligible subgroup. The second phase of recruitment involved contacting 1 randomly selected eligible woman enumerated by each household, based on return of the questionnaire. These women (n = 599) were invited by field interviewers to participate in a one‐time in‐person health survey.FindingsOf the women invited to participate, a total of 408 completed the interview. Based on American Association for Public Opinion Research Response Rate 1 calculations, the response rates were 44.4% and 70.3% for phases 1 and 2, respectively. Response rates in this study were encouraging, especially for the second phase in‐person interview.ConclusionWe discuss implications for future research using a mixed‐mode approach in this subpopulation.
Rural and Appalachian Disparities in Neonatal Abstinence Syndrome Incidence and Access to Opioid Abuse Treatment
Authors: Brown Joshua D. , Goodin Amie J. , Talbert Jeffery C. 
Published: July 2017

AbstractObjectiveIncidence of neonatal abstinence syndrome (NAS) is increasing due to the rise in opioid use. Rural states like Kentucky have been disproportionally impacted by opioid abuse, and this study determines NAS burden nationally and in Kentucky while quantifying differences in access to care between Appalachian and non‐Appalachian counties.MethodsNAS rates were calculated using National (2013) and Kentucky (2008‐2014) National Inpatient Sample discharge data. Births were identified using International Classification of Diseases v9 code 779.5 and live birth codes V30.x‐V38.x. Counties were classified as rural, micropolitan, or metropolitan using census data. Proximity analysis was conducted via mapping from ZIP code centroid to nearest opioid treatment facility. Distance to treatment facilities was calculated and then compared using nonparametric testing for counties by rural and Appalachian status.ResultsNAS cases tripled from 2008 to 2014 in Kentucky counties, with a 2013 NAS rate more than double the national NAS rate. Rural and Appalachian counties experienced an NAS increase per 1,000 births that was 2‐2.5 times higher than urban/non‐Appalachian counties, with a greater number of NAS births overall in Appalachian counties. All opioid treatment facility types were further from rural patients than micropolitan/metropolitan patients (P < .001), as well as further for Appalachians versus non‐Appalachians (P < .001, all facility types).ConclusionsNAS burden disparately affects rural and Appalachian Kentucky counties, while treatment options are disproportionately further away for these residents. Policy efforts to increase NAS prevention and encourage opioid abuse treatment uptake in pregnant women should address rural and Appalachian disparities.
Correlates of Injection Drug Use Among Rural Appalachian Women
Authors: Staton Michele , Ciciurkaite Gabriele , Havens Jennifer , Tillson Martha , Leukefeld Carl , Webster Matthew , Oser Carrie , Peteet Bridgette 
Published: July 2017

AbstractBackgroundLimited research has focused on correlates of injection drug use (IDU) among high‐risk subgroups of drug users, particularly women, who may be at increased risk for transmission of infectious diseases such as HIV and Hepatitis C. The purpose of this study is to better understand the contextual and health correlates of IDU among women living in rural Appalachia by examining (1) differences between injectors and noninjectors, and (2) the unique correlates of recent IDU and past IDU.MethodsThis study involved random selection, screening, and face‐to‐face interviews with 400 rural Appalachian women from jails in one state. Analyses included descriptive statistics, multinomial logistic regression, and stepwise regression to identify significant correlates of recent IDU and past IDU compared to never injecting.ResultsFindings indicated that 75.3% of this randomly selected sample reported lifetime injection of drugs. Contextual factors including drug use severity (RRR = 8.66, P < .001), more male sex partners (RRR = 1.01, P < .05), and having injecting partners (RRR = 7.60, P < .001) were robust correlates of recent injection practices.ConclusionsThis study makes an important contribution to understanding factors associated with IDU among rural Appalachian women drug users, which are strongly associated with both relational and health factors. Study findings on the specific factors associated with IDU risk have important implications for tailoring and targeting interventions that should include a focus on the relationship context reducing high‐risk injection practices.
Otomanguean historical linguistics: Exploring the subgroups
Authors: Campbell Eric W. 
Published: July 2017

AbstractThis is the second of two articles that survey and assess progress and prospects in the historical linguistics of the Otomanguean language family, which is the most widely distributed and most diverse linguistic lineage of Mesoamerica. While considerable progress has been made in understanding the linguistic and cultural history of Otomanguean, in some ways, it remains the Mesoamerican language family about which we know the least. It consists of eight major subgroups: Mè'phàà‐Subtiaba, Chorotegan, Oto‐Pamean, Chinantec, Mixtecan, Amuzgo, Zapotecan, and Popolocan. While the first article of this series addressed the historical linguistics of the higher levels of the Otomanguean family, this article focuses on the eight major subgroups, especially progress in their reconstruction, internal subgrouping, and areas in need of further research.
Fundamentals of inferencing during reading
Authors: Cook Anne E. , O'Brien Edward J. 
Published: July 2017

AbstractOver the last few decades, research on inferencing in comprehension has advanced considerably—across several cross‐disciplinary domains of study and levels of analysis. The goal of this paper was to review major theoretical approaches to inferencing, and discourse comprehension in general, as well as the evidence that these approaches generated. We then turn our focus to challenges for existing accounts of inferencing, and in doing so, we propose a new theoretical framework—the RI‐Val model. It is our hope that the points raised here will provide new directions for research in the field.
Diapause and overwintering of two spruce bark beetle species
Authors: Schebeck Martin , Hansen E. Matthew , Schopf Axel , Ragland Gregory J. , Stauffer Christian , Bentz Barbara J. 
Published: July 2017

AbstractDiapause, a strategy to endure unfavourable conditions (e.g. cold winters) is commonly found in ectothermic organisms and is characterized by an arrest of development and reproduction, a reduction of metabolic rate, and an increased resistance to adversity. Diapause, in addition to adaptations for surviving low winter temperatures, significantly influences phenology, voltinism and ultimately population growth. We review the literature on diapause and overwintering behaviour of two bark beetle species that affect spruce‐dominated forests in the northern hemisphere, and describe and compare how these strategies can influence population dynamics. The European spruce bark beetle Ips typographus (L.) (Coleoptera, Curculionidae) is the most important forest pest of Norway spruce in Europe. It enters an adult reproductive diapause that might be either facultative or obligate. Obligate diapausing beetles are considered strictly univoltine, entering this dormancy type regardless of environmental cues. Facultative diapausing individuals enter diapause induced by photoperiod, modified by temperature, thus being potentially multivoltine. The spruce beetle Dendroctonus rufipennis (Kirby) (Coleoptera: Curculionidae) infests all spruce species in its natural range in North America. A facultative prepupal diapause is averted by relatively warm temperatures, resulting in a univoltine life cycle, whereas cool temperatures induce prepupal diapause leading to a semivoltine cycle. An adult obligate diapause in D. rufipennis could limit bi‐ or multivoltinism. We discuss and compare the influence of diapause and overwinter survival on voltinism and population dynamics of these two species in a changing climate and provide an outlook on future research.
RANTES levels as a determinant of falciparum malaria severity or recovery
Authors: Bujarbaruah D. , Kalita M. P. , Baruah V. , Basumatary T. K. , Hazarika S. , Begum R. H. , Medhi S. , Bose S. 
Published: July 2017

SummaryThe study explored the role of differential RANTES concentrations, its receptor CCR5 expression and resulting immunomodulation in the pathogenesis and/or recovery from falciparum malaria. The study population included cases of uncomplicated malaria (UC‐M, N=128, enrolled on follow‐up basis), severe malaria (SM, N=25), and healthy controls (N=112). Serum RANTES and TNF‐α levels were evaluated by ELISA. Monocyte levels and activation profile were studied by flow cytometry. Differential mRNA expression profile was studied by real‐time PCR. Blood parasite count was evaluated by registered pathologists. RANTES concentration was significantly downregulated in SM cases compared to UC‐M (P=.046) and controls (P<.001). Expression of monocyte marker mCD14, activation markers CCR5 and CD40, and downstream effector cytokine TNF‐α was significantly higher in malaria cases compared to controls, in SM cases compared to UC‐M. TNF‐α expression correlated positively with CD40 and CCR5 expressions. Follow‐up‐based analysis showed that RANTES concentrations increased on recovery compared to baseline in UC‐M cases (P=.106) and inversely correlated with malaria parasite load, mCD14, CCR5 and CD40, and TNF‐α expressions. These findings suggest an important association of RANTES concentrations in Plasmodium falciparum malaria disease pathogenesis, as well as recovery, mediated through differential modulation and regulated activation of monocytes and cytokine TNF‐α.
Practicing a Virtuous Politics: Bill Bolling and the Atlanta Community Food Bank
Authors: Thomas John Clayton 
Published: July 2017

AbstractBill Bolling created the Atlanta Community Food Bank (ACFB) in 1979 and, as its executive director from then until 2015, transformed a fledgling effort in a church basement into the “equivalent of a $100 million company.” This article tells the story of how Bolling built the ACFB from scratch, arguing that his accomplishments can be traced to his effectiveness as a political leader. The article explains how Bolling practiced a virtuous politics in building informal sources of power and in developing and applying political skills on behalf of the ACFB. In the process, the article challenges the traditional critical scholarly view of political leadership, offering Bolling as a case illustration of an emerging theory of a benevolent and effective form of political leadership.
Iridociliary cysts masquerading as neoplasia in cats: a morphologic review of 14 cases
Authors: Fragola Jessica A. , Dubielzig Richard R. , Bentley Ellison , Teixeira Leandro B. C. 
Published: July 2017

AbstractObjectiveTo report 14 neoplasia‐free feline eyes enucleated for suspected intraocular neoplasia containing only iridociliary cysts. To analyze clinical findings that may have led veterinarians to suspect neoplasia in these globes.ProceduresThe archives at the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) were searched to identify neoplasia‐free feline globes enucleated for suspected neoplasia. Clinical data were obtained from medical records, veterinarian surveys, and COPLOW submission forms. All samples were examined grossly and histologically.ResultsAll eyes were free of neoplasia and contained one or more iridociliary cysts. Nine of 14 globes were enucleated by or based on the recommendation of a board‐certified veterinary ophthalmologist. In eight of 14 cases, the submitting clinician listed melanoma as the only suspected diagnosis; in six of 14 cases, ‘tumor’ or ‘mass’ was listed. Clinical examination revealed a darkly pigmented intraocular mass in 11 of 14 cases. The mass was clinically perceived to be within the iris in seven of 14 cases. When examined histologically, 11 of 14 eyes contained multiple cysts, 13 of 14 contained multiloculated cysts, eight of 14 had a hyperplastic iris pigmented epithelium or cysts with thick black walls, and five of 14 had cysts prolapsed into the anterior chamber.ConclusionsAlthough most iridociliary cysts in cats are easily diagnosed on clinical examination, a subset may be mistaken for neoplasia. In cases of suspected iris melanoma, iridociliary cysts should be considered as a differential diagnosis, especially if a mass appears to emanate from behind the iris, dyscoria is present, or if similar changes are noted in the contralateral eye.
Complete Genome Sequences of Three Representative Mycobacterium tuberculosis Beijing Family Strains Belonging to Distinct Genotype Clusters in Hanoi, Vietnam, during 2007 to 2009
Authors: Wada Takayuki , Hijikata Minako , Maeda Shinji , Hang Nguyen Thi Le , Thuong Pham Huu , Hoang Nguyen Phuong , Hung Nguyen Van , Keicho Naoto 
Published: July 2017

ABSTRACT

We present here three complete genome sequences of
Mycobacterium tuberculosis
Beijing family strains isolated in Hanoi, Vietnam. These three strains were selected from major genotypic clusters (15-MIRU-VNTR) identified in a previous population-based study. We emphasize their importance and potential as reference strains in this Asian region.
Genome Sequence of Oxalobacter formigenes Strain HC-1
Authors: Hatch Marguerite , Allison Milton J. , Yu Fahong , Farmerie William 
Published: July 2017

ABSTRACT

The lack of
Oxalobacter formigenes
colonization of the human gut has been correlated with the formation of calcium oxalate kidney stones and also with the number of recurrent kidney stone episodes. Here, we present the genome sequence of HC-1, a human strain isolated from an individual residing in Iowa, USA.
Draft Genome Sequence of Lactobacillus paracasei DmW181, a Bacterium Isolated from Wild
Drosophila
Authors: Hammer Austin J. , Walters Amber , Carroll Courtney , Newell Peter D. , Chaston John M. 
Published: July 2017

ABSTRACT

The draft genome sequence of
Lactobacillus paracasei
DmW181, an anaerobic bacterium isolate from wild
Drosophila
flies, is reported here. Strain DmW181 possesses genes for sialic acid and mannose metabolism. The assembled genome is 3,201,429 bp, with 3,454 predicted genes.
Complete Genome Sequences of 15 Chikungunya Virus Isolates from Puerto Rico
Authors: Sanders Wes A. , Long Kristin , Rivera Brenda , Vincent Heather A. , Heise Mark T. , Rodriguez-Orengo Jose F. , Moorman Nathaniel J. 
Published: July 2017

ABSTRACT
Here, we report the complete genome sequences of 15 chikungunya virus strains isolated from human plasma from infected patients in Puerto Rico. The results show that currently circulating chikungunya strains in Puerto Rico are closely related.
Risk factors for exertional rhabdomyolysis with renal stress
Authors: Apeland Terje , Danielsen Tore , Staal Eva M , Åsberg Anders , Thorsen Inga S , Dalsrud Tom Ole , Ørn Stein 
Published: July 2017

BackgroundExercise-induced rhabdomyolysis denotes the exertional damage of myocytes with leakage of sarcoplasmic content into the circulation. The purpose of this study was to determine important risk factors for the development of exertional rhabdomyolysis in a temperate climate and to study the renal effects of myoglobinuria.MethodsA cluster of eight military recruits was admitted to hospital due to exertional rhabdomyolysis with myoglobinuria. The patients were treated according to current guidelines with isotonic saline and alkalinisation of the urine. The eight patients were compared with a randomly selected control group of 26 healthy fellow recruits. All subjects responded to a standardised questionnaire.ResultsThere were little differences in baseline characteristics between patients and controls. In the present study, exercise intensity, duration and type were all significant determinants of exertional rhabdomyolysis in univariate models. However, in a multivariate model, high exercise intensity on day −1 was the only significant predictor of rhabdomyolysis (p=0.02). All patients had a stable serum creatinine and cystatin C. There was a significant increase in serum neutrophil gelatinase-associated lipocalin (NGAL) in the patients, suggesting renal stress.ConclusionsSustained maximal intensity exercise is a crucial risk factor for rhabdomyolysis with gross pigmenturia. Elevated serum NGAL concentrations indicate the presence of renal stress. It appears to be possible to quantify the risk of rhabdomyolysis by means of a simple questionnaire. In the future, this may be used as a tool to prevent rhabdomyolysis.
The Challenges at JSW Steel: Brand Valuation and Corporate Governance Issues
Authors: Mohanty Pitabas , Stephen Tina 
Published: July 2017

The shareholders of JSW Steel received a list of 24 items that would be put to vote in the AGM of the company, to be held on 31 July, 2014 along with the annual report of the company for the 2013–14 fiscal year. Item No. 23 of this list was a surprising addition, as the company stated that the brand name ‘JSW’ belongs to a private company called JSW Investments Private Limited (JSWIPL), promoted by Ms. Sangeeta Jindal, the wife of Mr. Sajjan Jindal, the Managing Director of JSW Jindal. It further stated that henceforth JSW Steel would pay 0.25% of the net consolidated turnover to JSWIPL for the use and promotion of the brand. The stock price fell in reaction to this news. JSW Steel justified its move by arguing that payment of royalties for the use of brand name is a common practice followed by Indian business groups. Many corporate governance experts, however, called this an abusive transaction and advised the shareholders to vote against the proposal. This case allows the examination of issues such as related party transactions and their corporate governance implications and the relevance of brand valuation for a steel company.
The Panjal Traps
Authors: Shellnutt J. Gregory 
Published: July 2017

Abstract

The Early Permian (290 Ma) Panjal Traps are the largest contiguous outcropping of volcanic (basaltic, andesitic and silicic) rocks within the Himalaya that are associated with the Late Palaeozoic break-up of Gondwana. The basaltic Panjal Traps have compositional characteristics that range from continental tholeiite to ocean-floor basalt but it is clear that crustal contamination has played a role in their genesis. The basalts that show limited evidence for contamination have Sr–Nd isotopes (
87
Sr/
86
Sr
i
= 0.7043–0.7073; ϵ
Nd
(
t
) = 0 ± 1) similar to a chondritic (subcontinental lithospheric mantle) source, whereas the remaining basaltic rocks have a wide range of Nd (ϵ
Nd
(
t
) = −6.1 to +4.3) and Sr (
87
Sr/
86
Sr
i
= 0.7051–0.7185) isotopic values. The primary melt composition of the low-Ti Panjal Traps is picritic with mantle potential temperatures (
T
P
= 1400°C to 1450°C) similar to ambient mantle. The silicic volcanic rocks were derived by partial melting of the crust, whereas the andesitic rocks were derived by mingling between crustal and mantle melts. The Panjal Traps initially erupted within a continental rift setting. The rift eventually transitioned into a nascent ocean basin that led to seafloor spreading and the formation of the Neotethys Ocean and the ribbon-like continent Cimmeria.
The carotid baroreflex modifies the pressor threshold of the muscle metaboreflex in humans
Authors: Ichinose Masashi , Ichinose-Kuwahara Tomoko , Watanabe Kazuhito , Kondo Narihiko , Nishiyasu Takeshi 
Published: July 2017

The purpose of the present study was to test our hypothesis that unloading the carotid baroreceptors alters the threshold and gain of the muscle metaboreflex in humans. Ten healthy subjects performed a static handgrip exercise at 50% of maximum voluntary contraction. Contraction was sustained for 15, 30, 45, and 60 s and was followed by 3 min of forearm circulatory arrest, during which forearm muscular pH is known to decrease linearly with increasing contraction time. The carotid baroreceptors were unloaded by applying 0.1-Hz sinusoidal neck pressure (oscillating from +15 to +50 mmHg) during ischemia. We estimated the threshold and gain of the muscle metaboreflex by analyzing the relationship between the cardiovascular responses during ischemia and the amount of work done during the exercise. In the condition with unloading of the carotid baroreceptors, the muscle metaboreflex thresholds for mean arterial blood pressure (MAP) and total vascular resistance (TVR) corresponded to significantly lower work levels than the control condition (threshold for MAP: 795 ± 102 vs. 662 ± 208 mmHg and threshold for TVR: 818 ± 213 vs. 572 ± 292 kg·s, P < 0.05), but the gains did not differ between the two conditions (gain for MAP: 4.9 ± 1.7 vs. 4.4 ± 1.6 mmHg·kg·s−1·100 and gain for TVR: 1.3 ± 0.8 vs. 1.3 ± 0.7 mmHg·l−1·min−1·kg·s−1·100). We conclude that the carotid baroreflex modifies the muscle metaboreflex threshold in humans. Our results suggest the carotid baroreflex brakes the muscle metaboreflex, thereby inhibiting muscle metaboreflex-mediated pressor and vasoconstriction responses. NEW & NOTEWORTHY We found that unloading the carotid baroreceptors shifts the pressor threshold of the muscle metaboreflex toward lower metabolic stimulation levels in humans. This finding indicates that, in the normal loading state, the carotid baroreflex inhibits the muscle metaboreflex pressor response by shifting the reflex threshold to higher metabolic stimulation levels.
Immunodeficiency in Pancreatic Adenocarcinoma with Diabetes Revealed by Comparative Genomics
Authors: Yan Yuanqing , Gao Ruli , Trinh Thao L.P. , Grant Maria B. 
Published: July 2017

AbstractPurpose: Pancreatic adenocarcinomas (PAAD) often are not diagnosed until their late stages, leaving no effective treatments. Currently, immunotherapy provides a promising treatment option against this malignancy. However, a set of immunotherapy agents benefit patients with many types of cancer, but not PAAD. Sharing the origin in the same organ, diabetes and PAAD tend to occur concurrently. We aimed to identify the impact of diabetes on immunotherapy of PAAD by conducting a comparative genomics analysis.Experimental Design: We analyzed level 3 PAAD genomics data (RNAseq, miRNAseq, DNA methylation, somatic copy number, and somatic mutation) from The Cancer Genome Atlas (TCGA) and Firehose. The differential molecular profiles in PAAD with/out diabetes were performed by the differential gene expression, pathway analysis, epigenetic regulation, somatic copy-number alteration, and somatic gene mutation.Results: Differential gene expression analysis revealed a strong enrichment of immunogenic signature genes in diabetic individuals, including PD-1 and CTLA4, that were currently targetable for immunotherapy. Pathway analysis further implied that diabetic individuals were defective in immune modulation genes. Somatic copy-number aberration (SCNA) analysis showed a higher frequency of amplification and deletion occurred in the cohort without diabetes. Integrative analysis revealed strong association between differential gene expression, and epigenetic regulations, however, seemed not affected by SCNAs. Importantly, our somatic mutation analysis showed that the occurrence of diabetes in PAAD was associated with a large set of gene mutations encoding genes participating in immune modulation.Conclusions: Our analysis reveals the impact of diabetes on immunodeficiency in PAAD patients and provides novel insights into new therapeutic opportunities. Clin Cancer Res; 23(20); 6363–73. ©2017 AACR.