bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internet-Delivered Self-management Support for Improving Coronary Heart Disease and Self-management–Related Outcomes
Authors: Palacios Jorge , Lee Geraldine A. , Duaso Maria , Clifton Abigail , Norman Ian J. , Richards Derek , Barley Elizabeth Alexandra 
Published: January 2017

Introduction:
Coronary heart disease (CHD) is associated with significant morbidity and mortality, including mental health comorbidity, which is associated with poor outcomes. Self-management is key, but there is limited access to self-management support. Internet-delivered interventions may increase access.

Objective:
The aim of this study was to conduct a systematic review to (1) determine the effectiveness of Internet-delivered CHD self-management support for improving CHD, mood, and self-management related outcomes and (2) identify and describe essential components for effectiveness.

Method:
Randomized controlled trials that met prespecified eligibility criteria were identified using a systematic search of 3 healthcare databases (Medline, PsychINFO, and Embase).

Results:
Seven trials, which included 1321 CHD patients, were eligible for inclusion. There was considerable heterogeneity between studies in terms of the intervention content, outcomes measured, and study quality. All 7 of the studies reported significant positive between-group effects, in particular for lifestyle-related outcomes. Personalization of interventions and provision of support to promote engagement may be associated with improved outcomes, although more data are required to confirm this. The theoretical basis of interventions was poorly developed though evidence-based behavior change interventions were used.

Conclusion:
More well-designed randomized controlled trials are needed. These should also explore how interventions work and how to improve participant retention and satisfaction and examine the role of personalization and support within interventions.
Home-based drainage of refractory ascites by a permanent-tunneled peritoneal catheter can safely replace large-volume paracentesis
Authors: Solbach Philipp , Höner zu Siederdissen Christoph , Taubert Richard , Ziegert Szilvia , Port Kerstin , Schneider Andrea , Hueper Katja , Manns Michael P. , Wedemeyer Heiner , Jaeckel Elmar 
Published: January 2017

Background and aim
Refractory ascites has a poor prognosis. Recurrent large-volume paracentesis is the current standard of care; however, it results in circulatory dysfunction and renal dysfunction, and hospitalization is commonly required. Transjugular intrahepatic portosystemic shunt placement is not an option in a substantial number of patients because of contraindications. The placement of a tunneled peritoneal drainage catheter has been shown to be effective in patients with malignant ascites. However, data in patients with nonmalignant refractory ascites are rare.

Patients and methods
We followed 24 consecutive patients in whom tunneled peritoneal drainage catheters were placed in the Endoscopy Unit at Hannover Medical School between June 2013 and December 2014.

Results
Catheters were placed in 24 patients with refractory ascites in end-stage liver disease and with a contraindication to transjugular intrahepatic portosystemic shunt placement. Placement was technically successful in all patients. The dosage of diuretics could be reduced significantly. The number of paracentesis decreased from 2.2±1 to 0 per week, although the volume of daily ascites removal remained stable (2 l). Despite frequent drainage of ascites, kidney function, serum sodium, and serum albumin remained stable. Seven adverse events occurred in six (25%) patients. Five patients listed for liver transplantation underwent successful transplantation without a negative impact.

Conclusion
The tunneled peritoneal drainage catheter placement is a viable and effective treatment alternative in patients with refractory ascites because of end-stage liver disease, reducing diuretic intake and the need for paracentesis. The procedure avoids hyponatremia, worsening kidney function, and albumin infusions without an increased risk of spontaneous bacterial peritonitis.
Two-dimensional shear-wave elastography: a new method comparable to acoustic radiation force impulse imaging?
Authors: Schellhaas Barbara , Strobel Deike , Wildner Dane , Goertz Ruediger S. , Neurath Markus F. , Pfeifer Lukas 
Published: January 2017

Objectives
Two-dimensional shear-wave elastography (2D-SWE) is an ultrasound-based technique for the noninvasive assessment of tissue stiffness. In contrast to the well-established point-shear-wave elastography (pSWE) method acoustic radiation force impulse imaging, there is little evidence on the performance and usefulness of 2D-SWE in the assessment of liver stiffness. Thus, the aim of our study was to compare 2D-SWE versus pSWE.

Materials and methods
2D-SWE and pSWE were performed in 20 cirrhotic patients, 20 healthy individuals and an elasticity phantom. Stiffness values, examination time and number of measurements were compared. For 2D-SWE, the influence of size of the region of interest (ROI) was assessed.

Results
Elastography values in healthy individuals were slightly higher for 2D-SWE versus pSWE (1.4 m/s, range: 1.21–1.68 vs. 1.23 m/s, range: 1.07–1.39). In cirrhotic patients, there were no significant differences (3.06 m/s, range: 1.83–5.35 vs. 3 m/s, range: 1.67–4.37 m/s). Examination times were significantly longer for 2D-SWE in both patient groups (mean values for healthy/cirrhotic patients: 129.6/157.1 vs. 75/71.6 s). For 2D-SWE, variation of ROI size (5, 10, 20 mm) produced comparable results. After eight measurements, 90% of cirrhotic patients showed less than 5% of deviation from the results after the gold standard of 10 measurements; for healthy individuals, this was observed after six measurements.

Conclusion
2D-SWE seems to be comparable to pSWE (acoustic radiation force impulse-imaging) in cirrhotic patients, with slightly higher values in healthy individuals. 2D-SWE measurements require considerably more time. For 2D-SWE, ROI size seems to be of minor importance; multiple measurements should be obtained as single measurements differ. These preliminary results should be confirmed in larger patient collectives with histology as the reference standard.
Liver Stiffness Measured by Shear‐wave Elastography for Evaluating Intrahepatic Portal Hypertension in Children
Authors: Yoon Hee Mang , Kim So Yeon , Kim Kyung Mo , Oh Seak Hee , Ko Gi‐Young , Park Yangsoon , Lee Jin Seong , Jung Ah Young , Cho Young Ah 
Published: January 2017

ABSTRACTObjectives:The aim of the study was to correlate liver stiffness (LS) and hepatic venous‐pressure gradient (HVPG) and to evaluate the diagnostic performance of shear‐wave elastography (SWE) for predicting clinically significant portal hypertension in children with suspected liver diseases, in consideration of the reliability criteria.Methods:We identified 33 SWEs from 32 children who underwent HVPG measurement within 2 weeks between June 2012 and October 2015. The correlation between LS and HVPG was assessed. The diagnostic performance for predicting clinically significant portal hypertension (HVPG ≥ 10 mmHg) was assessed using the receiver‐operating characteristic curve. Reliable measurement was evaluated based on the coefficient of variation (CV).Results:LS was significantly correlated with HVPG (r = 0.742, P < 0.001). The area under the receiver‐operating characteristic curve for predicting clinically significant portal hypertension was 0.914, and the best cutoff value of 18.4 kPa showed sensitivity of 87.5% and specificity of 84.0%. LS measurements having CV ⩽ 0.2 were significantly correlated with HVPG (r = 0.774, P < .001), whereas those having CV > 0.2 did not show a significant correlation with HVPG (r = 0.598, P = 0.089).Conclusions:SWE had excellent diagnostic performance for predicting clinically significant portal hypertension in children with suspected liver diseases. LS measurements having CV ⩽ 0.2 may possibly be used as a reliability criterion in SWE measurement.
Enhancements in Confidence, Acceptance, and Friendship at a Summer Camp for Children With Inflammatory Bowel Disease
Authors: McCombie Andrew , Gearry Richard B. , Lopez Robert N. , Lönnfors Sanna , Day Andrew S. 
Published: January 2017

ABSTRACTInflammatory bowel disease (IBD) affects many children and adolescents in terms of their confidence, acceptance, and ability to build friendships. New Zealand held its first summer camp for children with IBD in January 2015. We obtained feedback from the campers (ages 10–18 years) in terms of their confidence, acceptance, and quality of life. We also asked what experience was most beneficial to them, whether they made new friends with IBD, and if they would attend the camp again. Thirty‐six campers responded (81.8% response rate; median age 14 years [range 10–18]; 83.3% Crohn disease; 41.7% girls). Most reported that the camp improved their confidence (86.1%), acceptance (83.3%), and overall quality of life (75.0%) relating to IBD. Moreover, most reported that meeting their fellow campers was the most beneficial experience to come from the camp (72.2%). Overall, these results emphasize the importance and relevance of such an undertaking.
The Dyadic Effects of Family Cohesion and Communication on Health-Related Quality of Life: The Moderating Role of Sex
Authors: Lim Jung-won , Shon En-jung 
Published: January 2017

Background:
Spouses’ ability to care for survivors can be particularly challenging because patients and spouses are interdependent and mutually influence one another. Family functioning such as family cohesion and communication may play a primary role in improving the health-related quality of life (HRQOL) of couples, given that cancer can influence family dynamics.

Objective:
The aims of this study were to investigate the mediating effect of family communication on the relationship between family cohesion and HRQOL and examine the moderating effect of sex on this relationship among cancer survivor–spouse dyads.

Methods:
A total of 91 cancer survivors with a diagnosis of breast, colorectal, or prostate cancer and their spouses were recruited from the University Hospital Registry in Cleveland, Ohio. The dyadic data were analyzed using structural equation modeling with the actor-partner interdependence mediation model.

Results:
Findings demonstrated that the spouses’ own perceived family communication mediated the associations between their own family cohesion and physical HRQOL and between the survivors’ family cohesion and physical HRQOL. The spouse actor effects between family communication and HRQOL significantly differed by sex.

Conclusions:
Enhancing family cohesion and communication within the family can improve the spouses’ HRQOL. Findings regarding sex differences serve as a rationale for gender-based approaches to improving HRQOL in survivorship care in the family context.

Implications for Practice:
Couple- and/or family-based interventions should be designed to enhance family cohesion and improve family communication skills for effective adjustments within couples and families. Supportive care within the family context can be promoted to address the diverse challenges of survivorship care.
Overweight Kidney Transplant Recipients Are at Risk of Being Overdosed Following Standard Bodyweight-Based Tacrolimus Starting Dose
Authors: Andrews Louise M. , de Winter Brenda C.M. , Tang Jiang-Tao , Shuker Nauras , Bouamar Rachida , van Schaik Ron H.N. , Koch Birgit C.P. , van Gelder Teun , Hesselink Dennis A. 
Published: January 2017

Background
Bodyweight-based dosing of tacrolimus (Tac) is considered standard care, even though the available evidence is thin. An increasing proportion of transplant recipients is overweight, prompting the question if the starting dose should always be based on bodyweight.

Methods
For this analysis, data were used from a randomized-controlled trial in which patients received either a standard Tac starting dose or a dose that was based on CYP3A5 genotype. The hypothesis was that overweight patients would have Tac overexposure following standard bodyweight-based dosing.

Results
Data were available for 203 kidney transplant recipients, with a median body mass index (BMI) of 25.6 (range, 17.2-42.2). More than 50% of the overweight or obese patients had a Tac predose concentration above the target range. The CYP3A5 nonexpressers tended to be above target when they weighed more than 67.5 kg or had a BMI of 24.5 or higher. Dosing guidelines were proposed with a decrease up to 40% in Tac starting doses for different BMI groups. The dosing guideline for patients with an unknown genotype was validated using the fixed-dose versus concentration controlled data set.

Conclusions
This study demonstrates that dosing Tac solely on bodyweight results in overexposure in more than half of overweight or obese patients.
A New Hyperprior Distribution for Bayesian Regression Model with Application in Genomics
Authors: Silva Renato Rodrigues 
Published: January 2017

AbstractIn the regression analysis, there are situations where the model have more predictor variables than observations of dependent variable, resulting in the problem known as “large p small n”. In the last fifteen years, this problem has been received a lot of attention, specially in the genome-wide context. Here we purposed the bayes H model, a bayesian regression model using mixture of two scaled inverse chi square as hyperprior distribution of variance for each regression coefficient. This model is implemented in the R package BayesH.
Cortical elasticity determines the geometry of prospective mesoderm constriction inDrosophila melanogaster
Authors: Doubrovinski Konstantin 
Published: January 2017

1SummaryAn animal embryo begins its life as a ball of epithelial cells. In the course of development, invariably, this cellular ball will undergo a process of gastrulation to form a multilayered structure with the different germ layers designated to form organs with different shapes and functions. In the fruit flyDrosophia melanogaster, gastrulation begins with the constriction of mesodermal cells that make up a rectangular domain in the ventral part of the embryo. A remarkable aspect of this morphogenetic event is its anisotropy - the mesoderm constricts much more along one axis than along the other. In this paper we propose an explanation of this observed anisotropy. Specifically, we show that tissue contraction must be anisotropic, provided that the tissue is elastic and that the contractile domain is elongated (e.g. rectangular as opposed to square). This conclusion is generic in the sense that it does not depend on the specific values of model parameters. Since our recent study demonstrated that embryonic tissue is elastic on a developmentally relevant time-scale, it appears likely that the anisotropy of mesoderm contraction is an elastic effect. Our model makes a number of specific predictions that appear in close agreement with the available data.
Unjani “clinics in a container”: social franchising in South Africa
Authors: Sutherland Margie , Krige Kerryn 
Published: January 2017

Subject area
This case study focuses on social entrepreneurship in emerging markets, looking at what is social entrepreneurship, theories of market failure, opportunity generation through effectuation, social franchising and funding.

Study level/applicability
Students of social entrepreneurship, development studies, sustainable livelihoods and asset-based development. It is useful for customised or short programmes or for students with a background in business (e.g. Diploma in Business Administration/MBA/custom programmes) wanting to understand social enterprise and blended theories of social and economic change.

Case overview
The case tells the story of Unjani container clinics which are providing affordable, quality access to people who struggle to access South Africa’s crumbling public health system. Dr Iain Barton recognised the role that nurses can play to relieve pressure on the system, by providing primary healthcare. He piloted Unjani using shipping containers as clinics with support from his company, Imperial Health Sciences. The story of Unjani is therefore one of startup and sustainable growth, partnership and building independent, self-sustaining social enterprises in a franchising system. The theory explored includes the importance of context, the role of market failure in spotting opportunity, developing opportunity through effectuation, defining social entrepreneurship and funding and growing the organisation.

Expected learning outcomes
The teaching objectives are framed by Mair (2010) who finds that where social entrepreneurs operate affects what they do and how they do it. Objective 1: Explores the influence of context on social entrepreneurship helping students frame a definition of social entrepreneurship. Objective 2: Students are able to connect the theory of market failure to opportunity identification and effectuation for social entrepreneurs. Objective 3: Students apply the definition of social entrepreneurship based on Santos’ (2010) Positive Theory. Objective 4: Students will be able to apply knowledge of social franchising models, as an approach to scaling. Objective 5: Students understand the principles of resource dependency theory and are able to use the funding spectrum as a tool to identify funding types.

Supplementary materials
Links to two videos are provided in the case. Recommendations are also made for materials to be used in the class, e.g. Global Competitiveness Index and Gapminder World, which are excellent tools to demonstrate the social and economic growth divide.

Subject code
CSS 3: Entrepreneurship.
A comprehensive internal quality assurance system at University of Minho
Authors: Santos Isabel M. , Dias Graciete 
Published: January 2017

Purpose
The European Standards and Guidelines (ESG) for quality assurance (QA) adopted at the Bergen Ministerial Meeting in 2005 in the scope of the Bologna process call upon higher education institutions to take up a systematic approach to internal QA. Standard 1.1 of the ESG establishes that institutions should have a policy and associated procedures for the assurance of the quality and standards of their programmes and awards. University of Minho (UMinho) has a longstanding experience on innovative methods for the coordination and management of the teaching and learning processes, including, since 1991, systematic mechanisms for the evaluation of teaching. However, to fulfil the new demands raised by the ESG UMinho felt the need to define a formal institutional quality policy, building upon the existing procedures and mechanisms in order to set up a comprehensive internal QA system (SIGAQ-UM) fully compatible with the ESG. The purpose of this paper is to present the distinctive features of SIGAQ-UM, the procedures involved in its certification by Agency for Assessment and Accreditation of Higher Education (A3ES), as well as on the perceived impact on the university’s activities, including some comments on the difficulties to develop and consolidate a quality culture embedded in all the academic community.

Design/methodology/approach
Case study approach.

Findings
SIGAQ-UM is a fully operational comprehensive internal QA system certified by the Portuguese Agency A3ES in January 2013, with considerable impact on the university’s operation.

Originality/value
Disclosure of best practices on QA in higher education.
Supply chain management practices and firms’ operational performance
Authors: Truong Huy Quang , Sameiro Maria , Fernandes Ana Cristina , Sampaio Paulo , Duong Binh An Thi , Duong Hiep Hoang , Vilhenac Estela 
Published: January 2017

PurposeThe purpose of this paper is to provide an empirical evidence about the relationship between practices of supply chain management (SCM) and operational performance (OP).Design/methodology/approachBased on a comprehensive literature review, a set of SCM practices has been identified and selected to develop a conceptual model as well as to establish their relationship to companies’ OP. The measurement scales of the practices were developed in four steps: identification and development of initial instrument; personal interviews and Q-sort; large-scale data collection; and large-scale analysis in order to ensure unidimensionality, reliability and validity. Structural equation modeling was used to validate the model with the data were collected in Vietnamese garment enterprises.FindingsThe study consolidated relationships between the SCM practices and OP. According to the research results, these practices have a “resonant” influence on OP that can explain 52.6 percent variance of this output concept. In particular, customer focus and supplier management both direct and indirect impact on OP while top management support and process control/improvement only have indirect and direct influences on OP, respectively.Research limitations/implicationsThere are some limitations that can guide academics to new lines of future research: to extend the scope of the survey to include different countries and new situations, so results can be generalized; to consider the impacts of the SCM practices on the entire supply chain performance; and to explore additional factors that can further explain OP, such as operational environment, capital, technology, human resource, etc.Practical implicationsThe authors suggest that the SCM practices should be implemented as an integrated system rather than independent practices, in which they interact with each other and improve OP.Originality/valueThe empirical results of this study provide an evidence to consider the SCM practices as reliable predictors for OP. According to the research, these practices interact with each other and have both direct and indirect effects on OP. In other words, through the mutual interaction among the SCM practices, they have the “resonant” influence on improving OP. Moreover, the proposed research model analyzing the relationship among SCM practices and OP and its validation using the Vietnam garment industry provided valuable insights both from theoretical and practical perspectives.
A standard proposal for biological resources centres
Authors: Martins Anabela , Lima Nelson , Sampaio Paulo 
Published: January 2017

PurposeThe purpose of this paper is to contribute to develop a standard providing requirements for managing the quality and competence of the biological resource centres (BRC).Design/methodology/approachThe methodology for the standard setting was based on the principles of credibility, transparency, alignment and consistency. A justification study was performed to establish its objectives and scope, avoid overlap and prevent the risks in implementation. International documents providing rules for standard development were taken into consideration. Requirements were assembled from several standards and participation of interested parties was promoted.FindingsNo relevant international document exists covering fundamental issues for BRC operation. It is possible to develop a consistent and aligned standard, under a credible and transparent process that fits BRC purposes.Practical implicationsThis standard will strengthen the BRC technical competence increasing its capability to provide authenticated high-quality biological materials – a crucial factor for biotechnological developments in the fields of health, agriculture and environment. It will serve as a basis for the BRC compliance assessment and the launch pad for establishing the global BRC network.Originality/valueOriginal paper.