bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the influence of environmental indicators and forecasting influenza incidence using ARIMAX models
Authors: Zheng Xiaoyan , Chen Qingquan , Sun Mengcai , Zhou Quan , Shi Huanhuan , Zhang Xiaoyang , Xu Youqiong 
Published: September 2024

BackgroundInfluenza is a respiratory infection that poses a significant health burden worldwide. Environmental indicators, such as air pollutants and meteorological factors, play a role in the onset and propagation of influenza. Accurate predictions of influenza incidence and understanding the factors influencing it are crucial for public health interventions. Our study aims to investigate the impact of various environmental indicators on influenza incidence and apply the ARIMAX model to integrate these exogenous variables to enhance the accuracy of influenza incidence predictions.MethodDescriptive statistics and time series analysis were employed to illustrate changes in influenza incidence, air pollutants, and meteorological indicators. Cross correlation function (CCF) was used to evaluate the correlation between environmental indicators and the influenza incidence. We used ARIMA and ARIMAX models to perform predictive analysis of influenza incidence.ResultsFrom January 2014 to September 2023, a total of 21,573 cases of influenza were reported in Fuzhou, with a noticeable year-by-year increase in incidence. The peak of influenza typically occurred around January each year. The results of CCF analysis showed that all 10 environmental indicators had a significant impact on the incidence of influenza. The ARIMAX(0, 0, 1) (1, 0, 0)12 with PM10(lag5) model exhibited the best prediction performance, as indicated by the lowest AIC, AICc, and BIC values, which were 529.740, 530.360, and 542.910, respectively. The model achieved a fitting RMSE of 2.999 and a predicting RMSE of 12.033.ConclusionThis study provides insights into the impact of environmental indicators on influenza incidence in Fuzhou. The ARIMAX(0, 0, 1) (1, 0, 0)12 with PM10(lag5) model could provide a scientific basis for formulating influenza control policies and public health interventions. Timely prediction of influenza incidence is essential for effective epidemic control strategies and minimizing disease transmission risks.
Interactions between muscle volume and body mass index on brain structure in the UK Biobank
Authors: Lu Alicia , Than Stephanie , Beare Richard , La Hood Alexandra , Collyer Taya Annabelle , Srikanth Velandai , Moran Chris 
Published: September 2024

BackgroundLow skeletal muscle volume may increase dementia risk through mechanisms affecting brain structure. However, it is unclear whether this relationship exists outside of sarcopenia and/or varies by other factors. We aimed to study the interplay between skeletal muscle volume and factors, such as age, sex, and body mass index (BMI), in explaining brain structure at midlife in a cohort without sarcopenia.MethodsWe used abdominal and brain magnetic resonance imaging (MRI) data from a population-based cohort enrolled in the UK Biobank. The following measures were derived: thigh fat-free muscle volume (FFMV), total brain volume (TBV), gray matter volume (GMV), white matter volume (WMV), total hippocampal volume (THV), and white matter hyperintensity volume (WMHV). Participants below sex-based grip strength thresholds suggesting probable sarcopenia were excluded. Linear regression analysis was used to study the interaction or mediation effects of age, sex, and BMI on the associations between FFMV and brain volumes.ResultsData were available for 20,353 participants (median age 64 years, 53% female). We found interactions between thigh FFMV, BMI, and age (all p &lt; 0.05). Greater thigh FFMV was associated with better brain volumes in those aged &lt;64 years with normal (TBV: β = 2.0 ml/L, p = 0.004; GMV: β = 0.8 ml/L, p = 0.04; WMV: β = 1.1 ml/L, p = 0.006; WMHV: β = −0.2 ml/L, p = 3.7 × 10−5) or low BMI (TBV: β = 21.2 ml/L, p = 0.003; WMV: β = 13.3 ml/L, p = 0.002, WMHV: β = −1.1 ml/L, p = 0.04).ConclusionGreater thigh muscle volume correlates with better brain volumes at midlife in people without sarcopenia, but this relationship weakens with greater age and BMI. Further study is required to investigate the underlying mechanisms to understand which components of body composition are potentially modifiable risk factors for dementia.
Childhood growth of singletons conceived following intracytoplasmic sperm injection – irrelevance of gonadotropin stimulation
Authors: Minger M. A. , Sommer G. , Mitter V. R. , Purtschert L. A. , von Wolff M. , Kohl Schwartz A. S. 
Published: September 2024

BackgroundIn conventional, gonadotropin stimulated, in vitro fertilization or intracytoplasmic sperm injection (c-IVF/ICSI) growth and development of multiple follicles is induced by gonadotropins, combined with gonadotropin-releasing hormone agonist or antagonist. In recent studies, singletons conceived after c-IVF/ICSI cycles had lower birth weight not only than spontaneously conceived children but also children born after unstimulated natural IVF/ICSI cycles (NC-IVF/ICSI). Lower birth weight is associated with a catch-up growth within the first years of life. Following the Barker hypothesis accelerated growth has been associated with a higher risk of cardiovascular diseases later in life. The aim of the study is to assess, if children conceived with NC-IVF/ICSI have a higher birthweight and therefore do not show a catch-up growth within the first two years. Therefore, we assume that children born after NC-IVF/ICSI have a better long-term cardiometabolic risk profile. Whether the weight- and height gain is comparable to spontaneously conceived children is unknown, since to our knowledge we are the first study to investigate the longitudinal growth of children born after unstimulated natural cycle ICSI (NC-ICSI).Material and methodsWe conducted a single-center, prospective cohort study (2010-2017) including children (n = 139) born after NC-ICSI or c-ICSI treatment. Growth parameters up to 24 months were collected. Standard deviation scores based on growth references were calculated.ResultsThe study included 98 children in the NC-ICSI and 41 children in the c-ICSI group. The median birth weight in NC-ICSI children was 3.4 kg [0.1 standard deviation score (SDS)] compared to 3.3 kg (−0.3 SDS) in c-ICSI children (p = 0.61). Median length at birth was 50 cm in both groups (NC-ICSI (−0.5 SDS), c-ICSI children (−0.8 SDS), p = 0.48). At age 24 months, median weight in NC-ICSI children was 12.2 kg (0.3 SDS) versus 12.2 kg (0.2 SDS) in c-ICSI children (p = 0.82) and median length 87.5 cm (0.1 SDS) versus 88.0 cm (0.4 SDS) (p = 0.43).ConclusionWe found no difference in growth between children conceived after stimulated and unstimulated ICSI. Growth parameters of both treatment groups did not differ from Swiss national growth references (N = 8500). One of the main limitations of our study was the small sample size (N = 139) of complete data sets over time and the high drop-out rate of 49% (68/139). Nevertheless, with the increasing number of children born after IVF/ICSI every year it is of immense importance to search for possibilities to reduce their long-term cardiometabolic risk and we want our data to contribute to this discussion.
Financial analysis of a locomotor exercise trial for post-stroke recovery: insights from the HIT Stroke Trial
Authors: Hazen Emily M. , Bartsch Bria L. , Billinger Sandra A. 
Published: September 2024

BackgroundNavigating the complexities of post-stroke recovery trials requires addressing challenges in participant recruitment and retention and effective resource management to ensure trial success. The aim of this study was to examine the financial requirements associated with conducting the Moderate-Intensity Exercise vs. High-Intensity Interval Training to Recover Walking Post-Stroke (HIT Stroke Trial) at a single site encompassing a wide catchment area, recognizing the intricate challenges of participant recruitment and retention inherent in post-stroke recovery trials.MethodsTo determine cost, study expense reports were gathered and divided into seven categories: recruitment, screening assessments, baseline assessments, intervention, outcome assessments, retention, and oversight. Categories were then further divided into chronological order for initial contact and prescreening, consenting, initial screening, and baseline testing. The 12-week intervention was divided into 4-week blocks: intervention block 1, post 4-week outcome testing, intervention block 2, post 8-week outcome testing, intervention block 3, and post 12-week outcome testing.ResultsTotal direct cost for site execution was $539,768 with cost per participant approximated as $35,984. Oversight costs accounted for 65.8% of the budget at $355,661. To achieve goals related to inclusive participant recruitment ($21,923) and retention ($28,009), our site costs totaled $49,932. Direct study-related costs included screening assessments ($5,905), baseline assessments ($15,028), intervention ($76,952), and outcome assessments ($36,288).DiscussionClinical trials focusing on walking rehabilitation and exercise, particularly those requiring multiple assessment visits, demand rigorous oversight. This cost analysis provides important and critical insight into the expenses required to successfully execute an exercise-based walking rehabilitation trial in the United States.
The impact of information acquisition ability on consumers' trust in eco-labels in China: insight of food sustainability
Authors: Yang Yanyan , Xue Fang , Qiao Guanghua 
Published: September 2024

IntroductionThe lack of trust in eco-labels is a significant reason for the slow growth in demand for sustainable food, and reducing the information gap between relevant parties is a crucial means to improve consumer trust in eco-labels.MethodsIn order to investigate the influence and driving pathways of consumers' information acquisition abilities on their trust in eco-labels, a total of 1,072 urban and rural consumers in Inner Mongolia, China were surveyed in this study, with an analysis conducted using the structural equation model.ResultsIt was found that information acquisition ability, institutional trust, and label knowledge have significant direct impacts on eco-label trust, with impact effects of 0.270, 0.351, and 0.357, respectively. Additionally, information acquisition ability has indirect effect of 0.085 and 0.127 on label trust through institutional trust and label knowledge. Furthermore, information discernment awareness has a significant negative moderating effect between information acquisition ability and label trust.DiscussionTherefore, when publicizing the certification system and label knowledge, cultivating consumers' information acquisition ability effectively enhances eco-label trust. Moreover, strengthening media supervision to ensure the authenticity and objectivity of information transmission is an important measure to protect trust in eco-labels. This study enriches relevant research in the field of food sustainability and provides valuable recommendations to promote sustainable food consumption.
Enhancing laying performance and immunity via probiotic and vitamin additives during induced molting
Authors: Wang Chunyang , Xiao Sa , Yang Zengqi 
Published: September 2024

IntroductionMolting is induced in commercial laying hens to rejuvenate the reproductive system and increase egg production. However, this process causes stress and reduces bird health and performance.MethodsThe experiment was conducted to study the effect of multi probiotics and vitamin additives on induced molting in 240 ISA Brown hens. Hens were randomly divided into four groups receiving probiotic and vitamin additives (I–IV) during different period of molting. During the whole molting process, the laying performance indexes such as egg laying rate, egg quality, ovary weight and oviduct lengths were measured, and the spleen index, serum immunoglobulin, immune response of NDV and AIV vaccine were monitored.ResultsMolted hens resumed 50% egg production in just 37 days, with 1.62% mortality. Egg quality such as egg weight, yolk color, Haugh unit, eggshell strength and protein height were significantly improved. After the second production peak, the reproductive organs and immune organs returned to normal, and the immune antibody titer of NDV vaccine increased significantly.DiscussionMolting with probiotic and vitamin additives improve the laying performance and egg quality, reduce mortality, significantly improve immune function and vaccine titer, and help to enhance disease resistance and maintain production performance of aged laying hens.
Regenerative treatment of canine osteogenic lesions with Platelet-Rich Plasma and hydroxyapatite: a case report
Authors: Barbaro Katia , Marconi Giorgio , Innocenzi Elisa , Altigeri Annalisa , Zepparoni Alessia , Monteleone Valentina , Alimonti Cristian , Marcoccia Daniele , Ghisellini Paola , Rando Cristina , Ottoboni Stefano , Rau Julietta V. , Eggenhöffner Roberto , Scicluna Maria Teresa 
Published: September 2024

IntroductionThis study examined the efficacy of a therapy based on a combination of Platelet Rich Plasma and hydroxyapatite nanoparticles in a severe clinical case involving a young Rottweiler with a complex spiral fracture of the tibia.MethodFollowing a worsening of the lesion after traditional surgical intervention, the subject was treated with the combined therapy. X-rays were taken at the following stages: immediately post-surgery, four weeks post-surgery, and 10 days post-treatment. Fracture gap and callus density measurements were obtained using ImageJ analysis, allowing for a detailed quantitative assessment of bone regeneration over time.ResultsPost-operative radiographs indicated a clinical worsening of the fracture, revealing an increased fracture gap due to bone loss. However, significant improvements were observed ten days following the treatment, with a marked reduction in fracture gaps and increased callus density. These results demonstrated a notable acceleration in bone healing and callus formation compared to typical recovery times for similar lesions.ConclusionThe method showed potential for enhancing osteogenic regeneration, facilitating faster healing of serious orthopedic injuries compared to traditional methods.
The impact of Codonopsis Pilosulae and Astragalus Membranaceus extract on growth performance, immunity function, antioxidant capacity and intestinal development of weaned piglets
Authors: Guo Rongxia , Zhang Hao , Jiang Chenghui , Niu Chun , Chen Baoxia , Yuan Ziwen , Wei Yanming , Hua Yongli 
Published: September 2024

IntroductionThe objective of this study was to examine the impact of Codonopsis pilosula and Astragalus membranaceus extract (CA) on the growth performance, diarrhea rate, immune function, antioxidant capacity, gut microbiota, and short-chain fatty acids (SCFAs) in weaned piglets.MethodsA total of forty-eight 31-day-old weaned piglets, were divided into four groups randomly based on the treatment type: control group (CON), low dose group (LCA, 0.5% CA), medium dose group (MCA, 1.0% CA), and high dose group (HCA, 1.5% CA), and were fed for a duration of 28 days. On the morning of the 1st and 29th day, the piglets were assessed by weighing them on an empty stomach, recording their daily feed intake and diarrhea rate.ResultsCA increased the average daily weight gain and reduced F/G without significant differences, and the diarrhea rate was reduced in the LCA and MCA groups. Furthermore, the levels of T-AOC, SOD, GSH-Px, and MDA were increased. The levels of T-AOC in the LCA group and the MCA group, SOD in the MCA group, and GSH-Px in the HCA group were significantly higher compared with the CON group (p &lt; 0.05). Additionally, CA significantly increased IgM, IgG, and IgA levels (p &lt; 0.05). The results of gut microbiota analysis showed that the bacterial population and diversity of faeces were changed with the addition of CA to basal diets. CA increased the abundance of the beneficial bacterial Firmicutes and Lactobacillus. Additionally, Compared with the CON group, CA significantly increased the SCFAs content of weaned piglets (p &lt; 0.05).DiscussionCA can alleviate oxidative stress, improve immunity and antioxidant capacity, increase the abundance of beneficial bacteria, and the content of SCFAs for improving the intestinal barrier of piglets, thus promoting growth and reducing diarrhea rate in weaned piglets.
Higher Nodal expression is often associated with poorer survival in patients diagnosed with melanoma and treated with anti-PD1 therapy
Authors: Gascard Philippe D. , Wang Xianhong , Nosrati Mehdi , Kim Kevin B. , Kashani-Sabet Mohammed , Tlsty Thea D. , Leong Stanley P. , Hendrix Mary J. C. 
Published: September 2024

Advanced melanoma is considered the most aggressive and deadly form of skin cancer whose incidence has been rising over the past three decades. In the absence of treatment, the median overall survival for advanced-stage metastatic disease is less than 6 months. Although most melanomas detected at an early stage can be cured with surgery, a subset of these eventually metastasize. Therefore, a critical need exists to identify unique molecular features that would be predictive of long-term outcome and response to specific therapies. Recent promising therapeutic regimens have included the use of immune checkpoint inhibitors, such as anti-PD1 antibodies. However, the ability to identify responders and non-responders to this therapy remains elusive. To address this challenge at the molecular level, previously our laboratory identified the emergence of a stem cell phenotype associated with advanced melanoma and other aggressive forms of cancer. Underlying this phenotype is the aberrant re-expression of the embryonic morphogen “Nodal”. Particularly noteworthy, we have observed Nodal to remain in advanced tumors of non-responders to standard-of-care therapies (i.e., BRAFi). This pilot study is the first proof-of-principle attempt to predict treatment response survival outcome in a small cohort of melanoma patients receiving anti-PD1 immune checkpoint inhibitor therapy – based on their Nodal expression profile. Using advanced multiplex immunohistochemistry-based digital pathology, the major finding of this preliminary study indicates that higher Nodal expression is often associated with poorer overall survival after anti-PD1 therapy, reaching nearly statistical relevance.
O impacto da acne na qualidade de vida de estudantes de medicina: um estudo observacional transversal
Authors: Bessa Beatriz Lopes , Viana Tiago Guedes de Oliveira , Salomão Paula de Rezende , Vianna Glaucia dos Santos 
Published: September 2024

Objetivo: Compreender o impacto e as consequências da presença de acne nos diferentes aspectos da qualidade de vida de acadêmicos de medicina. Métodos: Trata-se de um estudo observacional transversal realizado a partir da aplicação do teste Dermatology Life Quality Index (DLQI) em uma amostra de 320 indivíduos que cursam medicina em uma faculdade particular de Minas Gerais. Resultados: A partir da análise das respostas ao teste aplicado, observou-se que 23,7% dos participantes se mostraram “bastante” ou “muito” envergonhados/ preocupados com sua aparência por causa da acne na semana anterior à aplicação do teste. Ademais, 12,5% dos participantes relataram que sua pele estava “muito” ou “bastante” sensível e/ou dolorida. Porém, no que se refere a problemas sexuais, observou-se menor impacto, uma vez que 94% dos indivíduos responderam que a acne não afetou “nada”. Acerca da prática de esportes e do ambiente de trabalho/estudo, 91% e 96% dos entrevistados, respectivamente, alegaram que a acne não impediu “nada” a realização das atividades. Conclusão: As esferas mais impactadas pela dermatose foram a preocupação com a aparência e a sensibilidade da pele, enquanto a vida sexual, a prática de esportes e o ambiente de trabalho/estudo foram as menos afetadas. Portanto, conclui-se que a acne afeta de maneira heterogênea os diferentes âmbitos da vida dos acadêmicos de medicina.
Relação entre a Síndrome de Alice no País das Maravilhas e transtornos mentais: uma revisão bibliográfica
Authors: Oku Renata Maria Godê , Carassa Beatriz Pereira , Lima Mariana Machado 
Published: September 2024

Objetivo: Relacionar a Síndrome de Alice no País das Maravilhas com os Transtornos Mentais. Métodos: Este estudo é uma revisão integrativa da literatura, baseada em artigos disponíveis nas bases de dados Scientific Electronic Library Online, United States National Library of Medicine, Biblioteca Virtual em Saúde, Portal Capes, Literatura Latino-Americana e do Caribe em Ciências da Saúde e Google Scholar. Resultados/Revisão Bibliográfica: Dos 88 artigos revisados, um total de 9 foram incluídos neste estudo. A Síndrome de Alice no País das Maravilhas pode ser considerada tanto causa quanto consequência dos transtornos mentais. Teorias envolvendo distorções temporais e espaciais podem elucidar a conexão entre esses diagnósticos. Conclusão/Considerações finais: Este estudo compila relatos de casos em que a Síndrome de Alice no País das Maravilhas coexiste com transtornos mentais (transtornos de ansiedade, depressão ou bipolar), destacando a necessidade de mais pesquisas sobre critérios diagnósticos e estratégias de tratamento. Além disso, esta pesquisa contribui para a escassa literatura médica a respeito da Síndrome de Alice no País das Maravilhas.
THE IMPACT OF SMALL AND MEDIUM-SIZED TOURISM ENTERPRISES DIGITAL TRANSFORMATION ON THEIR COMPETITIVENESS
Authors: Xu Shiqiang , Xiao Xuan 
Published: September 2024

At present, China's economy has shifted from a high-speed growth stage to a high-quality development stage. At the macro level, high-quality development takes the form of high-quality economic development, while at the micro level, it manifests as high-quality enterprise development. High-quality enterprise development is the foundation of high-quality economic development.

This study explores the mechanism of the digital transformation of small and medium-sized tourism enterprises in terms of their competitiveness and analyzes the regulatory role of environmental uncertainty in the relationship between digital transformation and corporate competitiveness. From the perspective of tourism enterprises, it is necessary to improve the level of data application capabilities, build a digital talent training system, and transform organizational culture and management models; from the perspective of the government, it is necessary to improve the top-level design of digital transformation, build a favorable digital environment, and increase government support.