bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical, emotional and sexual adolescent abuse victimisation in South Africa: prevalence, incidence, perpetrators and locations
Authors: Meinck Franziska , Cluver Lucie D , Boyes Mark E , Loening-Voysey Heidi 
Published: June 2016

BackgroundPhysical, emotional and sexual abuse of children is a major problem in South Africa, with severe negative outcomes for survivors. To date, no known studies have used data directly obtained from community-based samples of children to investigate prevalence, incidence, locations and perpetrators of child abuse victimisation. This study aims to investigate prevalence and incidence, perpetrators, and locations of child abuse victimisation in South Africa using a multicommunity sample.Methods3515 children aged 10–17 years (56.6% female) were interviewed from all households in randomly selected census enumeration areas in two South African provinces. Child self-report questionnaires were completed at baseline and at 1-year follow-up (96.7% retention).ResultsPrevalence was 56.3% for lifetime physical abuse (18.2% past-year incidence), 35.5% for lifetime emotional abuse (12.1% incidence) and 9% for lifetime sexual abuse (5.3% incidence). 68.9% of children reported any type of lifetime victimisation and 27.1% reported lifetime multiple abuse victimisation. Main perpetrators of abuse were reported: for physical abuse, primary caregivers and teachers; for emotional abuse, primary caregivers and relatives; and for sexual abuse, girlfriend/boyfriends or other peers.ConclusionsThis is the first study assessing current self-reported child abuse through a large, community-based sample in South Africa. Findings of high rates of physical, emotional and sexual abuse demonstrate the need for targeted and effective interventions to prevent incidence and re-victimisation.
Entrepreneurial Intention among Freshmen Students — Application of the Theory of Planned Behaviour in Saudi Context
Authors: Aloulou Wassim J. 
Published: June 2016

This research aims to investigate whether attitude towards entrepreneurship, perceived entrepreneurial self-efficacy, social norm and gender predict entrepreneurial intentions of Saudi Freshmen students. Starting from the findings of GEM report in Kelley & al. (2010), entrepreneurial intention of Saudi people was recorded as the lowest rate of 1% among 59 countries. This research focuses on studying factors explaining intentions. Based on a literature review, we use a theoretical model of intention based on the Theory of Planned Behavior (Ajzen, 1991) which was tested earlier by Boissin et al. (2007a) to French context. We intend to retest it in Saudi context. We add gender as control variable and a potential predictor of intention. Then, we conduct a research survey from Autumn 2013 to Autumn 2014 of 289 Saudi (183 males and 106 females) students. The collected data was analyzed using the Structural Equation Modeling (SEM) through Partial Least Squares (PLS) technique. Then, results are shown and discussed, and finally, some recommendations are presented.
Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma
Authors: Dawkins Joshua B.N. , Wang Jun , Maniati Eleni , Heward James A. , Koniali Lola , Kocher Hemant M. , Martin Sarah A. , Chelala Claude , Balkwill Frances R. , Fitzgibbon Jude , Grose Richard P. 
Published: June 2016

Abstract
Genes encoding the histone H3 lysine 4 methyltransferases KMT2C and KMT2D are subject to deletion and mutation in pancreatic ductal adenocarcinoma (PDAC), where these lesions identify a group of patients with a more favorable prognosis. In this study, we demonstrate that low KMT2C and KMT2D expression in biopsies also defines better outcome groups, with median survivals of 15.9 versus 9.2 months (P = 0.029) and 19.9 versus 11.8 months (P = 0.001), respectively. Experiments with eight human pancreatic cell lines showed attenuated cell proliferation when these methyltransferases were depleted, suggesting that this improved outcome may reflect a cell-cycle block with diminished progression from G0–G1. RNA-seq analysis of PDAC cell lines following KMT2C or KMT2D knockdown identified 31 and 124 differentially expressed genes, respectively, with 19 genes in common. Gene-set enrichment analysis revealed significant downregulation of genes related to cell-cycle and growth. These data were corroborated independently by examining KMT2C/D signatures extracted from the International Cancer Genome Consortium and The Cancer Genome Atlas datasets. Furthermore, these experiments highlighted a potential role for NCAPD3, a condensin II complex subunit, as an outcome predictor in PDAC using existing gene expression series. Kmt2d depletion in KC/KPC cell lines also led to an increased response to the nucleoside analogue 5-fluorouracil, suggesting that lower levels of this methyltransferase may mediate the sensitivity of PDAC to particular treatments. Therefore, it may also be therapeutically beneficial to target these methyltransferases in PDAC, especially in those patients demonstrating higher KTM2C/D expression. Cancer Res; 76(16); 4861–71. ©2016 AACR.
A Novel HSP90 Inhibitor–Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer
Authors: Gaponova Anna V. , Nikonova Anna S. , Deneka Alexander Y. , Kopp Meghan C. , Kudinov Alexander E. , Skobeleva Natalia , Khazak Vladimir , Ogawa Luisa S. , Cai Kathy Q. , Duncan Kelly E. , Duncan James S. , Egleston Brian L. , Proia David A. , Boumber Yanis , Golemis Erica A. 
Published: June 2016

Abstract
Purpose: Small cell lung cancer (SCLC) is a highly aggressive disease representing 12% to 13% of total lung cancers, with median survival of &lt;2 years. No targeted therapies have proven effective in SCLC. Although most patients respond initially to cytotoxic chemotherapies, resistance rapidly emerges, response to second-line agents is limited, and dose-limiting toxicities (DLT) are a major issue. This study performs preclinical evaluation of a new compound, STA-8666, in SCLC.
Experimental Design: To avoid DLT for useful cytotoxic agents, the recently developed drug STA-8666 combines a chemical moiety targeting active HSP90 (concentrated in tumors) fused via cleavable linker to SN38, the active metabolite of irinotecan. We compare potency and mechanism of action of STA-8666 and irinotecan in vitro and in vivo.
Results: In two SCLC xenograft and patient-derived xenograft models, STA-8666 was tolerated without side effects up to 150 mg/kg. At this dose, STA-8666 controlled or eliminated established tumors whether used in a first-line setting or in tumors that had progressed following treatment on standard first- and second-line agents for SCLC. At 50 mg/kg, STA-8666 strongly enhanced the action of carboplatin. Pharmacokinetic profiling confirmed durable STA-8666 exposure in tumors compared with irinotecan. STA-8666 induced a more rapid, robust, and stable induction of cell-cycle arrest, expression of signaling proteins associated with DNA damage and cell-cycle checkpoints, and apoptosis in vitro and in vivo, in comparison with irinotecan.
Conclusions: Together, these results strongly support clinical development of STA-8666 for use in the first- or second-line setting for SCLC. Clin Cancer Res; 22(20); 5120–9. ©2016 AACR.
An FGFR3 Autocrine Loop Sustains Acquired Resistance to Trastuzumab in Gastric Cancer Patients
Authors: Piro Geny , Carbone Carmine , Cataldo Ivana , Di Nicolantonio Federica , Giacopuzzi Simone , Aprile Giuseppe , Simionato Francesca , Boschi Federico , Zanotto Marco , Mina Maria Mihaela , Santoro Raffaela , Merz Valeria , Sbarbati Andrea , de Manzoni Giovanni , Scarpa Aldo , Tortora Giampaolo , Melisi Davide 
Published: June 2016

Abstract
Purpose: The majority of gastric cancer patients who achieve an initial response to trastuzumab-based regimens develop resistance within 1 year of treatment. This study was aimed at identifying the molecular mechanisms responsible for resistance.
Experimental Design: A HER2+-trastuzumab sensitive NCI-N87 gastric cancer orthotopic nude mouse model was treated with trastuzumab until resistance emerged. Differentially expressed transcripts between trastuzumab-resistant and sensitive gastric cancer cell lines were annotated for functional interrelatedness by Ingenuity Pathway Analysis software. Immunohistochemical analyses were performed in pretreatment versus posttreatment biopsies from gastric cancer patients receiving trastuzumab-based treatments. All statistical tests were two-sided.
Results: Four NCI-N87 trastuzumab-resistant (N87-TR) cell lines were established. Microarray analysis showed HER2 downregulation, induction of epithelial-to-mesenchymal transition, and indicated fibroblast growth factor receptor 3 (FGFR3) as one of the top upregulated genes in N87-TR cell lines. In vitro, N87-TR cell lines demonstrated a higher sensitivity than did trastuzumab-sensitive parental cells to the FGFR3 inhibitor dovitinib, which reduced expression of pAKT, ZEB1, and cell migration. Oral dovitinib significantly (P = 0.0006) reduced tumor burden and prolonged mice survival duration in N87-TR mouse models. A higher expression of FGFR3, phosphorylated AKT, and ZEB1 were observed in biopsies from patients progressing under trastuzumab-based therapies if compared with matched pretreatment biopsies.
Conclusions: This study identified the FGFR3/AKT axis as an escape pathway responsible for trastuzumab resistance in gastric cancer, thus indicating the inhibition of FGFR3 as a potential strategy to modulate this resistance. Clin Cancer Res; 22(24); 6164–75. ©2016 AACR.
Prehospital Acute Stroke Severity Scale to Predict Large Artery Occlusion
Authors: Hastrup Sidsel , Damgaard Dorte , Johnsen Søren Paaske , Andersen Grethe 
Published: June 2016

Background and Purpose—
We designed and validated a simple prehospital stroke scale to identify emergent large vessel occlusion (ELVO) in patients with acute ischemic stroke and compared the scale to other published scales for prediction of ELVO.

Methods—
A national historical test cohort of 3127 patients with information on intracranial vessel status (angiography) before reperfusion therapy was identified. National Institutes of Health Stroke Scale (NIHSS) items with the highest predictive value of occlusion of a large intracranial artery were identified, and the most optimal combination meeting predefined criteria to ensure usefulness in the prehospital phase was determined. The predictive performance of Prehospital Acute Stroke Severity (PASS) scale was compared with other published scales for ELVO.

Results—
The PASS scale was composed of 3 NIHSS scores: level of consciousness (month/age), gaze palsy/deviation, and arm weakness. In derivation of PASS 2/3 of the test cohort was used and showed accuracy (area under the curve) of 0.76 for detecting large arterial occlusion. Optimal cut point ≥2 abnormal scores showed: sensitivity=0.66 (95% CI, 0.62–0.69), specificity=0.83 (0.81–0.85), and area under the curve=0.74 (0.72–0.76). Validation on 1/3 of the test cohort showed similar performance. Patients with a large artery occlusion on angiography with PASS ≥2 had a median NIHSS score of 17 (interquartile range=6) as opposed to PASS <2 with a median NIHSS score of 6 (interquartile range=5). The PASS scale showed equal performance although more simple when compared with other scales predicting ELVO.

Conclusions—
The PASS scale is simple and has promising accuracy for prediction of ELVO in the field.
Effect of temperature treatment on survival of Heterodera glycines and its associated fungi and bacteria
Authors: Hu Weiming , Chen Senyu , Liu Xingzhong 
Published: June 2016

In studies of nematode-suppressive soil and plant-parasitic nematode management, it is often desirable to kill nematodes in the soil but keep the microbial community alive. The effect of temperature treatment on survival ofHeterodera glycines, the soybean cyst nematode (SCN), and associated fungi and bacteria was investigated. Extracted eggs and cysts, and cysts in soil were subjected to treatments of temperatures ranging from −80 to 55°C for 1 to 24 h. Nematode survival was determined by hatchingin vitroand by infectivity and development in soybean, and fungal survival was determined by plating the eggs or cysts on potato dextrose agar. The nematodes survived well between −20 and 45°C, but could not survive at −80 or 48°C and above, while some nematodes were killed after heat treatment of 46°C. By contrast, fungi survived well in the cysts at −80°C, and also much better than nematodes at the high temperatures. Glasshouse studies demonstrated that both bacteria and fungi survived well in the soil treated with −80°C. Transferring 5% of −80°C-treated soil to autoclaved soil could effectively establish nematode suppressiveness. Our study demonstrated that freezing soil at −80°C can kill SCN but maintain nematode suppressiveness, and the soil treatment can improve the method for nematode-suppressive soil evaluation.
A reappraisal of leaf morphology in Aponogeton natans (Aponogetonaceae)
Authors: MANAWADUGE CHAPA G. , YAKANDAWALA DEEPTHI , LES DONALD H. 
Published: June 2016

The aquatic monocotyledon genus Aponogeton L.f. (Aponogetonaceae) consists of about 57 species distributed mainly in the tropical or subtropical regions of the Old world. Aponogeton natans (L.) Engler & Krause is the type species of the genus and occurs in India, Pakistan and Sri Lanka. During recent field work, which focused exclusively on Sri Lankan Aponogeton, we were unable to satisfactorily reconcile our collections of A. natans with the morphological descriptions given in several previously published accounts globally, as all description indicated the presence of submersed leaves. Detail investigation carried out with literature and the type specimens revealed that the presences of submersed leaves is only a misconception that was propagated by a misinterpretation of the Latin description provided by Krause & Engler in 1906. To clarify the nature of the foliage in A. natans we provide here a revised morphological description of this taxon along with an illustration and images.
The Ontario Winter Lake-Effect Systems Field Campaign: Scientific and Educational Adventures to Further Our Knowledge and Prediction of Lake-Effect Storms
Authors: Kristovich David A. R. , Clark Richard D. , Frame Jeffrey , Geerts Bart , Knupp Kevin R. , Kosiba Karen A. , Laird Neil F. , Metz Nicholas D. , Minder Justin R. , Sikora Todd D. , Steenburgh W. James , Steiger Scott M. , Wurman Joshua , Young George S. 
Published: June 2016

Abstract
Intense lake-effect snowstorms regularly develop over the eastern Great Lakes, resulting in extreme winter weather conditions with snowfalls sometimes exceeding 1 m. The Ontario Winter Lake-effect Systems (OWLeS) field campaign sought to obtain unprecedented observations of these highly complex winter storms.
OWLeS employed an extensive and diverse array of instrumentation, including the University of Wyoming King Air research aircraft, five university-owned upper-air sounding systems, three Center for Severe Weather Research Doppler on Wheels radars, a wind profiler, profiling cloud and precipitation radars, an airborne lidar, mobile mesonets, deployable weather Pods, and snowfall and particle measuring systems. Close collaborations with National Weather Service Forecast Offices during and following OWLeS have provided a direct pathway for results of observational and numerical modeling analyses to improve the prediction of severe lake-effect snowstorm evolution. The roles of atmospheric boundary layer processes over heterogeneous surfaces (water, ice, and land), mixed-phase microphysics within shallow convection, topography, and mesoscale convective structures are being explored.
More than 75 students representing nine institutions participated in a wide variety of data collection efforts, including the operation of radars, radiosonde systems, mobile mesonets, and snow observation equipment in challenging and severe winter weather environments.
Linking Meteorology, Turbulence, and Air Chemistry in the Amazon Rain Forest
Authors: Fuentes Jose D. , Chamecki Marcelo , Nascimento dos Santos Rosa Maria , Von Randow Celso , Stoy Paul C. , Katul Gabriel , Fitzjarrald David , Manzi Antonio , Gerken Tobias , Trowbridge Amy , Souza Freire Livia , Ruiz-Plancarte Jesus , Furtunato Maia Jair Max , Tóta Julio , Dias Nelson , Fisch Gilberto , Schumacher Courtney , Acevedo Otavio , Rezende Mercer Juliane , Yañez-Serrano Ana Maria 
Published: June 2016

Abstract
We describe the salient features of a field study whose goals are to quantify the vertical distribution of plant-emitted hydrocarbons and their contribution to aerosol and cloud condensation nuclei production above a central Amazonian rain forest. Using observing systems deployed on a 50-m meteorological tower, complemented with tethered balloon deployments, the vertical distribution of hydrocarbons and aerosols was determined under different boundary layer thermodynamic states. The rain forest emits sufficient reactive hydrocarbons, such as isoprene and monoterpenes, to provide precursors of secondary organic aerosols and cloud condensation nuclei. Mesoscale convective systems transport ozone from the middle troposphere, enriching the atmospheric boundary layer as well as the forest canopy and surface layer. Through multiple chemical transformations, the ozone-enriched atmospheric surface layer can oxidize rain forest–emitted hydrocarbons. One conclusion derived from the field studies is that the rain forest produces the necessary chemical species and in sufficient amounts to undergo oxidation and generate aerosols that subsequently activate into cloud condensation nuclei.
What is Missing from the Prescription of Hydrology for Land Surface Schemes?
Authors: Davison Bruce , Pietroniro Alain , Fortin Vincent , Leconte Robert , Mamo Moges , Yau M. K. 
Published: June 2016

AbstractLand surface schemes (LSSs) are of potential interest both to hydrologists looking for innovative ways to simulate river flow and the land surface water balance and to atmospheric scientists looking to improve weather and climate predictions. This paper discusses three ideas, which are grounded in hydrological science, to improve LSS predictions of streamflow and latent heat fluxes. These three possibilities are 1) improved representation of lateral flow processes, 2) the appropriate representation of surface heterogeneity, and 3) calibration to streamflow as a way to account for parameter uncertainty. The current understanding of lateral hydrological processes is described along with their representation of a selected group of LSSs. Issues around spatial heterogeneity are discussed, and calibration in hydrologic models and LSSs is examined. A case study of an evapotranspiration-dominated basin with over 10 years of extensive observations in central Canada is presented. The results indicate that in this particular basin, calibration of streamflow presents atmospheric modelers with a unique opportunity to improve upon the current practice of using lookup tables to define parameter values. More studies are needed to determine if model calibration to streamflow is an appropriate method for generally improving LSS-modeled heat fluxes around the globe.
The Occurrence, Drivers, and Implications of Submesoscale Eddies on the Martha’s Vineyard Inner Shelf
Authors: Kirincich Anthony 
Published: June 2016

AbstractThe occurrence, drivers, and implications of small-scale O(2–5) km diameter coherent vortices, referred to as submesoscale eddies, over the inner shelf south of Martha’s Vineyard, Massachusetts, are examined using high-frequency (HF), radar-based, high-resolution (400 m) observations of surface currents. Within the 300 km2 study area, eddies occurred at rates of 1 and 4 day−1 in winter and summer, respectively. Most were less than 5 h in duration, smaller than 4 km in diameter, and rotated less than once over their lifespan; 60% of the eddies formed along the eastern edge of study area, adjacent to Wasque Shoal, and moved westward into the interior, often with relative vorticity greater than f. Eddy generation was linked to vortex stretching on the ebb and flood tide as well as the interaction of the spatially variable tide and the wind-driven currents; however, these features had complex patterns of surface divergence and stretching. Eddies located away from Wasque Shoal were related to the movement of wind-driven surface currents, as wind direction controlled where eddies formed as well as density effects. Using an analysis of particles advected within the radar-based surface currents, the observed eddies were found to be generally leaky, losing 60%–80% of particles over their lifespan, but still more retentive than the background flow. As a result, the combined translation and rotational effects of the observed eddies were an important source of lateral exchange for surface waters over the inner shelf.
Investigation of models of the yarn-bobbin drying process by determination of their parameters using genetic algorithm
Authors: Susantez Çiğdem , Hacıhafızoğlu Oktay , Kahveci Kamil 
Published: June 2016

In the first part of this study, the drying behavior of wool-acrylic yarn bobbins was investigated by a theoretical model and genetic algorithm method. Each candidate solution for Do, D1 and D2 was presented on a single chromosome. The values of Do, D1 and D2 yielding the best fit between the experimental and predicted moisture contents were obtained using the genetic algorithm. In the second part of this study, the suitability of various empirical and semiempirical models in the modeling of the drying process was investigated by the genetic algorithm. The population number was taken as 30 and the tournament selection method was used. The calculations were performed until the 20th generation for the theoretical model and 100th generation for the empirical and semiempirical models. The results show that the genetic algorithm can be successfully used in the modeling of the drying process of yarn bobbins. The results also show that the Verma et al. and Diffusion Approach models yield the best fit with experimental data.