bluuebunny/crossref_metadata_2025_split huggingface dataset:
Participation and Intellectual Disability: A Review of the Literature
Authors: Dean Evan E. , Fisher Kim W. , Shogren Karrie A. , Wehmeyer Michael L. 
Published: November 2016

Abstract
Participation is a central aspect of human functioning and a key focus of research and practice in the intellectual disability field. However, there is not an accepted definition of participation that guides research and practice. To inform the development of a definition, a scoping review of the intellectual disability literature from 2001−2015 was conducted. Findings suggest that existing research rarely uses definitions of participation, but does examine participation across multiple domains and addresses issues of access and inclusion. Less focus was placed on individual aspects of participation such as meaning, responsibility, and choice. Based on the findings, implications for future research and practice are provided.
Women's Pathways to Abortion Care in South Carolina: A Qualitative Study of Obstacles and Supports
Authors: Margo Judy , McCloskey Lois , Gupte Gouri , Zurek Melanie , Bhakta Seema , Feinberg Emily 
Published: November 2016

AbstractCONTEXTWomen seeking timely and affordable abortion care may face myriad challenges, including high out‐of‐pocket costs, transportation demands, scheduling difficulties and stigma. State‐level regulations may exacerbate these burdens and impede women's access to a full range of care. Women's reports of their experiences can inform efforts to improve pathways to abortion care.METHODSIn 2014, semistructured qualitative interviews were conducted with 45 women obtaining abortions in South Carolina, which has a restrictive abortion environment. Interviews elicited information about women's pathways to abortion, including how they learned about and obtained care, whether they received professional referrals, and the supports and obstacles they experienced. Transcripts were examined using thematic analysis to identify key themes along the pathways, and a process map was constructed to depict women's experiences.RESULTSTwenty participants reported having had contact with a health professional or crisis pregnancy center staff for pregnancy confirmation, and seven of them received an abortion referral. Women located abortion clinics through online searches, previous experience, and friends or family. Financial strain was the most frequently cited obstacle, followed by transportation challenges. Women reported experiencing emotional strain, stress and stigma, and described the value of receiving social support. Because of financial pressures, the regulation with the greatest impact was the one prohibiting most insurance plans from covering abortion care.CONCLUSIONSFurther research on experiences of women seeking abortion services, and how these individuals are affected by evolving state policy environments, will help shape initiatives to support timely, affordable and safe abortion care in a climate of increasing restrictions.
Model dan Metoda Arsitektur pada Sistem Tanya Jawab Medis
Authors: Suwarningsih Wiwin , Supriana Iping , Purwarianti Ayu 
Published: November 2016

Pada makalah ini, akan dilakukan survey beberapa penelitian yang membahas mengenai sistem tanya jawab dengan domain pada bidang medis (medical question answering = MedQuAn). Sistem MedQuAn mengolah pertanyaan yang diajukan dalam bentuk teks bahasa alami dan kemudian sistem akan memberikan jawaban yang relevan. Makalah ini mencoba menelaah modul konseptual MedQuAn, bahwa sistem tanya jawab terdiri dari tiga komponen inti yang berbeda beserta metoda/ pendekatan yang digunakan. Ketiga komponen inti tersebut adalah klasifikasi pertanyaan, pencarian dokumen, dan ekstraksi jawaban. Hasil akhir dari survey ini adalah sebuah kontribusi untuk pengembangan penelitian di masa mendatang di domain MedQuAn khususnya untuk sistem tanya jawab medis dengan menggunakan bahasa Indonesia.
Metoda Adaptive Beamforming untuk Cognitive Radio
Authors: Subekti Agus 
Published: November 2016

Salah satu peluang pemanfaatan spektrum secara bersama antara secondary users dan primary users adalah dengan memanfaatkan perbedaan sudut datang sinyal (Angle of Arrival- AoA). Dengan aplikasi multi antena, arah berkas dari masing-masing dibentuk dan dapat diatur sehingga terfokus dan tidak saling mengganggu karena memberikan interferensi. Pada tulisan ini diusulkan teknik beamforming di sisi penerima. Arah berkas dari larik dibuat maksimum pada arah datang sinyal dan minimum pada arah referensi. Dengan algoritma LMS (Least Mean Square), pembobot dihitung secara iteratif agar memberikan nilai MSE (Minimum Square Error) dari sinyal keluaran larik dan sinyal referensi yang minimum. Algoritma yang diusulkan selanjutnya dicoba disimulasikan untuk beberapa nilai parameter step size.
Model Pengukuran Proses Bisnis CRM Berbasis eTom dan IT-IL
Authors: Saragih Lihardo Ranjaliba , Suprayitno Gendut , Dahlan Dahmir 
Published: November 2016

Saat ini perusahaan Telekomunikasi melakukan transformasi model bisnis melalui Manage service, untuk mengurangi beban biaya perusahaan. Perusahaan telekomunikasi sangat melekat dengan teknologi mutakhir dan padat modal, maka transformasi perlu dilakukan dengan pendekatan khusus sehingga dapat mempertahankan daya saing, bukan sekedar outsourcing karyawan umumnya. Hal ini kemudian mengubah paradigma outsourcing dalam industri telekomunikasi global dalam sebuah istilah Manage service.Perusahaan menyadari bahwa Manage service ternyatarumit didefinisikan apalagi dieksekusi, sehingga perlu dilakukan pengukuran tingkat kematangan dalam skala aktivitas atau proses bisnis yang akan dialihdayakan. Penelitian dilakukan untuk mengukur tingkat kematangan proses bisnis dalam Manage services, menghasilkan penataan ulang model bisnis perusahaan.Peneliti menggunakan framework eTOM dan IT-IL dalam mengukur unit bisnis "Customer Relationship Management - Customer Care" yang akan menerapkan Manage service. Hasil studi adalah berbagai aspek identifikasi terkait dengan layanan potensial outsourcing yang dikelola, saran restrukturisasi tata kelola sesuai dengan referensi tingkat kematangan, dan memberikan rekomendasi kebijakan yang tepat.
CIELab Color Moments: Alternative Descriptors for LANDSAT Images Classification System
Authors: Kusumaningrum Retno , Manurung Hisar Maruli , Arymurthy Aniati Murni 
Published: November 2016

This study compares the image classification system based on normalized difference vegetation index (NDVI) and Latent Dirichlet Allocation (LDA) using CIELab color moments as image descriptors. It was implemented for LANDSAT images classification by evaluating the accuracy values of classification systems. The aim of this study is to evaluate whether the CIELab color moments can be used as an alternatif descriptor replacing NDVI when it is implemented using LDA-based classification model. The result shows that the LDA-based image classification system using CIELab color moments provides better performance accuracy than the NDVI-based image classification system, i.e 87.43% and 86.25% for LDA-based and NDVI-based respectively. Therefore, we conclude that the CIELab color moments which are implemented under the LDA-based image classification system can be assigned as alternative image descriptors for the remote sensing image classification systems with the limited data availability, especially when the data only available in true color composite images.
AS TRANSFORMAÇÕES ADMINISTRATIVAS, POLÍTICAS PÚBLICAS E A EXECUÇÃO DO ORÇAMENTO GERAL DA UNIÃO – A FUNÇÃO DA CAIXA ECONÔMICA FEDERAL – CEF
Authors: Limberger Têmis , Quevedo Marcelo 
Published: November 2016

A Caixa Econômica Federal (CEF) passou gradativamentea atuar como braço operacional do governo federal na efetivaçãodas políticas públicas. O surgimento dessa atividade peculiar, nãotipicamente financeira\bancária, está intimamente relacionada aoesforço do Estado para produzir respostas capazes de enfrentaros desafios advindos das constantes e profundas transformaçõessocioeconômicas que marcam o pós Constituição de 1988. A atuaçãoda empresa na atividade econômica tem se fundamentadona realização de um duplo interesse coletivo, com uma funçãosocial econômica e outra eminentemente social. Essa inovadoraforma de prestação de serviços públicos tem permitido a superaçãoda cultura patrimonialista e incorporado importantes valoresda visão gerencial sem abdicar do controle público sobre a operacionalização das políticas, balizando-se pela consecução dosobjetivos Constitucionais de forma a assegurar a centralidadedos direitos individuais e sociais, afastando a atuação da administraçãopública dos desvios de modelos baseados principalmente no interesse econômico privado.
Universal Credit to Basic Income: A Politically Feasible Transition?
Authors: Martin Josh 
Published: November 2016

AbstractUniversal Credit, the UK working-age benefit, attempts to address issues of complexity, inflexibility, and work disincentivisation within the benefits system. However, the UK coalition government’s delayed rollout and emphasis on conditionality raise questions over its applicability to twenty-first century labour market problems. Instead, universal basic income tackles similar goals and arguably better addresses labour market changes. But is this transition politically feasible? Through interviews with policy actors from four UK political parties, arguments for and against the likelihood of this transition are presented by utilising theories of welfare state development.
Pharmacogenetic studies: a tool to improve antidepressant therapy
Authors: Ramos Marta , Berrogain Cecilia , Concha Julia , Lomba Laura , García Cristina Belén , Ribate Mª Pilar 
Published: November 2016

Abstract
The World Health Organization (WHO) predicts that major depressive disorder (MDD) will be the second leading cause of death and disability by 2020. Nowadays, approximately 60–70% of patients with this disorder have shown the lack of effectiveness and tolerability of the therapy with antidepressants. The US Food and Drug Administration (FDA) and the European Medicine Agency (EMA) are including pharmacogenetic information in the labeling of several antidepressants. The presence of this information represents the relevance of genetic polymorphisms in drug response. These pharmacogenetic studies have been based on the knowledge of genes involved in pharmacokinetic (CYP2D6, CYP2C19 and ABCB1) and pharmacodynamic (SLC6A4, HTR2A, BDNF, GNB3 and FKBP5) processes of antidepressant medications. The knowledge of the genotype of patients with MDD is an important tool for personalized therapy that can improve their clinical response to treatment. In this review, we highlight the most relevant genes involved in the metabolism of antidepressants (ADs) or the genes related to the presence of adverse reactions.
microRNA assays for acute coronary syndromes
Authors: Shirvani Samani Omid , Meder Benjamin 
Published: November 2016

AbstractmicroRNAs are promising biomarkers for diverse cardiovascular diseases. While quantification of the small non-coding RNAs is routinely performed in the research laboratory, clinical-grade assessment of microRNAs in central laboratory environments or point-of-care testing is still in its infancy. In this review, we provide an overview on microRNAs as biomarkers for acute coronary syndromes and highlight promising technical approaches for microRNA-based assays systems.
Heterocyclization of 5,6-disubstituted 3-alkenyl-2-thioxothieno[2,3-d]pyrimidin-4-one with p-alkoxyphenyltellurium trichloride
Authors: Kut Mykola , Onysko Mikhajlo , Lendel Vasyl 
Published: November 2016

Abstract
Electrophilic heterocyclization of 5,6-disubstituted 3-alkenyl-2-thioxothieno[2,3-d]pyrimidin-4-ones by treatment with p-alkoxyphenyltellurium trichlorides leads to annulation of the thiazoline moiety with the formation of 6,7-disubstituted-2-[dichloro-(p-alkoxyphenyl)telluromethyl]-2,3-dihydro-5Н-[1,3]thiazolo[3,2-а]thieno[2,3-d]pyrimidin-5-one hydrochlorides.
Using Relative Statistics and Approximate Disease Prevalence to Compare Screening Tests
Authors: Samuelson Frank , Abbey Craig 
Published: November 2016

Abstract:
Schatzkin et al. and other authors demonstrated that the ratios of some conditional statistics such as the true positive fraction are equal to the ratios of unconditional statistics, such as disease detection rates, and therefore we can calculate these ratios between two screening tests on the same population even if negative test patients are not followed with a reference procedure and the true and false negative rates are unknown. We demonstrate that this same property applies to an expected utility metric. We also demonstrate that while simple estimates of relative specificities and relative areas under ROC curves (AUC) do depend on the unknown negative rates, we can write these ratios in terms of disease prevalence, and the dependence of these ratios on a posited prevalence is often weak particularly if that prevalence is small or the performance of the two screening tests is similar. Therefore we can estimate relative specificity or AUC with little loss of accuracy, if we use an approximate value of disease prevalence.
Semi-Parametric Estimation and Inference for the Mean Outcome of the Single Time-Point Intervention in a Causally Connected Population
Authors: Sofrygin Oleg , van der Laan Mark J. 
Published: November 2016

Abstract
We study the framework for semi-parametric estimation and statistical inference for the sample average treatment-specific mean effects in observational settings where data are collected on a single network of possibly dependent units (e.g., in the presence of interference or spillover). Despite recent advances, many of the current statistical methods rely on estimation techniques that assume a particular parametric model for the outcome, even though some of the important statistical assumptions required by these methods are often violated in observational network settings. In this work we rely on recent methodological advances in the field of targeted maximum likelihood estimation (TMLE) and describe an estimation approach that permits for more realistic classes of data-generative models while providing valid inference in the context of observational network-dependent data. We start by assuming that the true data-generating distribution belongs to a large class of semi-parametric statistical models. We then impose some restrictions on the possible set of such distributions. For example, we assume that the dependence among the observed outcomes can be fully described by an observed network. We then show that under our modeling assumptions, our estimand can be described as a functional of the mixture of the observed data-generating distribution. With this key insight in mind, we describe the TMLE for possibly-dependent units as an iid data algorithm and we demonstrate the validity of our approach with a simulation study. Finally, we extend prior work towards estimation of novel causal parameters such as the unit-specific indirect and direct treatment effects under interference and the effects of interventions that modify the structure of the network.
Mucosal Protective Compounds in the Treatment of Gastroesophageal Reflux Disease. A Position Paper Based on Evidence of the Romanian Society of Neurogastroenterology
Authors: Surdea-Blaga Teodora , Băncilă Ion , Dobru Daniela , Drug Vasile , Frățilă Ovidiu , Goldiș Adrian , Grad Simona M. , Mureșan Crina , Nedelcu Laurențiu , Porr Paul J. , Sporea Ioan , Dumitrașcu Dan L. 
Published: November 2016

Background & Aims: Gastroesophageal reflux disease (GERD) therapy is challenging and suppression of acid secretion or prokinetics do not cure all cases. Some drugs with protective action on the esophageal mucosa have been used alternatively or in association with proton pump inhibitors (PPIs) and/or prokinetics. The Romanian Society of Neurogastroenterology undertook an Evidence-Based analysis, from which this position paper evolved.
Methods: We performed a systematic literature search in PubMed until October 2015, using the terms: sucralfate, guaiazulene, gaiazulene, dimethicone, alginate, antacids and gastroesophageal reflux. Forty-seven papers were included and analyzed. Several statements were elaborated regarding the use of these drugs in GERD. The evidence and recommendations were discussed between the authors.
Results: There is evidence in the medical literature suggesting the benefit of these drugs in GERD. In patients with persistent or mild reflux symptoms antacids rapidly relieve heartburn. Alginate-antacid combination is superior both over placebo and antacids to treat mild reflux symptoms, and can be used to treat persistent reflux symptoms despite acid suppressant therapy. Sucralfate is superior over placebo in alleviating GERD symptoms and can be used as maintenance therapy. Guaiazulene-dimethicone improves the quality of life in patients with GERD.
Conclusions: Drugs used to protect the esophageal mucosa against acid are useful in alleviating chronic heartburn, especially in patients with mild reflux symptoms.
Abbreviations: CS: Chondroitin sulfate; DA: Double Action; EE : Erosive esophagitis ; GERD: Gastroesophageal reflux disease; HA: Hyaluronic acid; H2RA: Histamine 2 receptor antagonist; ITT: Intention to treat; IM: Irsogladine maleate; NERD: Non-erosive reflux disease; PPIs: Proton pump inhibitors; RCT: Randomized controlled trial; RDQ: Reflux disease questionnaire; QoL: Quality of life.
Treatment Targets in Inflammatory Bowel Disease: Current Status in Daily Practice
Authors: Römkens Tessa E.H. , Gijsbers Kim , Kievit Wietske , Hoentjen Frank , Drenth Joost P.H. 
Published: November 2016

Background & Aims: Recently, treatment goals in inflammatory bowel disease (IBD) in clinical trials have shifted from mainly symptom-based to more mucosa-driven. Real world data on treatment priorities are lacking. We aimed to investigate the current practice and most commonly used definitions of IBD treatment targets among Dutch gastroenterologists.
Methods: Dutch gastroenterologists were asked to participate in a computer-based nation-wide survey. We asked questions on demographics, opinion and current practice regarding IBD treatment targets.
Results: Twenty-four percent (134/556) of the respondents completed the survey. For both Crohn’s disease (CD) (47.3%, 61/129) and ulcerative colitis (UC)(45%, 58/129) the main treatment goal was to achieve and maintain deep remission, defined as clinical, biochemical and endoscopic remission. Seventy-six percent of the participants use mucosal healing (MH) as a potential treatment target for IBD, whereas 22.6% use histological remission. There is no single definition for MH in IBD. The majority use Mayo score ≤ 1 in UC (52%) and ‘macroscopic normal mucosa’ in CD (66%).
Conclusion: More stringent and mucosa-driven treatment targets as ‘deep remission’ and ‘mucosal healing’ have found traction in clinical practice. The most commonly used definition for MH in routine practice is endoscopic MAYO score ≤ 1 in UC and ‘macroscopic normal mucosa’ in CD.
Abbreviations: CD: Crohn’s disease; CDEIS: Crohn‘s Disease Endoscopic Index of Severity; IBD: Inflammatory Bowel Disease; IBDU: IBD unclassified; IOIBD: International Organization for the Study of Inflammatory Bowel Diseases; MH: Mucosal healing; MMH: Microscopic mucosal healing; PROMS: Patient reported outcome measures; SES-CD: Simple endoscopic score for Crohn’s disease; UC: ulcerative colitis; UCEIS: Ulcerative Colitis Endoscopic Index of Severity.
Microbiota Small RNAs in Inflammatory Bowel Disease
Authors: Filip Anca T. , Balacescu Ovidiu , Marian Catalin , Anghel Andrei 
Published: November 2016

MiRNAs are a class of potential gene regulators of critical importance in Inflammatory Bowel Disease (IBD). This review aims to present the connection between gut microbiota, probiotics administration and microRNA (miRNA) expression in IBD. It also brings into question cross-kingdom RNAi (RNA interference). Not only that gut host cells garden the intestinal microbiome via miRNA, but also strong evidence supports the idea that different species of bacteria have an impact on the intestinal immune response by modulating miRNA expression. Cross-kingdom RNAi refers to RNA silencing signals that travel between two unrelated, interacting organisms. RNAs communication between prokaryotes and eukaryotes (bacteria and nematodes) via RNAs transfer has been proved. Some authors also support the idea that non-coding RNAs are being transferred by bacterial pathogens to the host cells as part of the intracellular infection process. Further studies are required in order to clarify whether the mechanism by which bacteria modulate miRNA expression concerns RNAs transfer. These findings may lead to a different approach to IBD therapy in the future.
Abbreviations: AChE: Acetylcholinesterase; AIEC: Adherent-invasive E coli; ATF: Activating transcription factor; Bcl-2: B-cell lymphoma 2; BMDC: Bone marrow-derived dendritic cells; C elegans: Caenorhabditis elegans; CCL: Chemokine C-C motif ligand; CD: Crohn’s disease; CDC42: Cell division control protein 42 homolog; CXCL: Chemokine (C-X-C motif) ligand; DC: Dendritic cells; E Coli: Escherichia coli; EcN: E coli Nissle; EPEC: Entheropathogenic E coli; FOXO3: Forkhead box protein O3; GF: Germ-free; IBD: Inflammatory bowel disease; IECs: Intestinal epithelial cells; IGLC: Immunoglobulin Lambda Constant Region; IkB: Inhibitor of NF-Kb; IL: Interleukin; IRGM: Immunity-related GTPase family M protein; L del: Lactobacillus delbrueckii; LGG: Lactobacillus rhamnosus GG; MAPK: Mitogen-activated protein kinases; miRNA: MicroRNA; mRNA: Messenger RNA; MyD88: Myeloid differentiation primary response gene 88; NF-kB: Nuclear factor kappa B; NOD2: Nucleotide-binding oligomerization domain-containing protein 2; PAR: Partitioning defective protein; RhoB: Ras Homolog Family Member B; RISC: RNA induced silencing complex; RNAi: RNA interference; SHH: Sonic hedgehog (gene); SPF: Specific-pathogen-free; SRNA: Small RNA; STAT3: Signal transducer and activator of transcription 3; TGF: Transforming growth factor; Th17: T helper 17 cells; TJ: Tight junction; TLR: Toll like receptor; TNF: Tumor necrosis factor; UC: Ulcerative colitis; Xcv: Xanthomonas campestris pv. Vesicatoria; ZO-2: Zonula occludens-2.
Noninvasive Assessment of Liver Diseases using 2D Shear Wave Elastography
Authors: Lupșor-Platon Monica , Badea Radu , Gersak Mirela , Maniu Anca , Rusu Ioana , Suciu Alina , Vicas Cristian , Stefănescu Horia , Urs Radu , Al Hajjar Nadim 
Published: November 2016

There has been great interest in the development of non-invasive techniques for the diagnosis of liver fibrosis in chronic liver diseases, including ultrasound elastographic methods. Some of these methods have already been adequately studied for the non-invasive assessment of diffuse liver diseases. Others, however, such as two-dimensional Shear Wave Elastography (SWE), of more recent appearance, have yet to be validated and some aspects are for the moment incompletely elucidated. This review discusses some of the aspects related to two-dimensional SWE: the examination technique, the examination performance indicators, intra and interobserver agreement and clinical applications. Recommendations for a high-quality examination technique are formulated.
Key words: – – – Two-dimensional Shear Wave Elastography.
Abbreviations: 2D- SWE: Two-dimensional Shear Wave Elastography; 3D- SWE: Three-dimensional Shear Wave Elastography; AUROC: area under the receiver operating characteristic curves; ARFI Acoustic Radiation Force Impulse Elastography; EFSUMB: European Federation of Societies for Ultrasound in Medicine and Biology; HVPG: hepatic venous pressure gradient; LS: liver stiffness; LR: likelihood ratio; NPV: negative predictive value; PPV: positive predictive value; ROI: region of interest; RT-E: Real Time-Elastography; Se: sensitivity; Sp: specificity; TE: Transient Elastography; US: ultrasound; VM: valid measurement; E: Young’s modulus