bluuebunny/crossref_metadata_2025_split huggingface dataset:
One‐year quality of life and functional outcomes of transoral robotic surgery for carcinoma of unknown primary
Authors: Ozbay Isa , Yumusakhuylu Ali Cemal , Sethia Rishabh , Wei Lai , Old Matthew , Agrawal Amit , Teknos Theodoros , Ozer Enver 
Published: May 2017

AbstractBackgroundThe purpose of this study was to assess the quality of life (QOL) outcomes in patients who underwent transoral robotic surgery (TORS) for carcinoma of unknown primary (CUP).MethodsTwenty‐nine patients with CUP were administered the Head and Neck Cancer Inventory (HNCI) prospectively to evaluate QOL preoperatively and postoperatively.ResultsThere was statistically and clinically significant deterioration in 2 of 4 domains (eating and social disruption) in the immediate aftermath of TORS. There was statistically and clinically meaningful deterioration in all 4 domains at 3 months relative to baseline, and there remained statistically and clinically meaningful deterioration in 2 of 4 domains at 6 months compared to baseline. These 2 domains remained statistically and clinically worse than baseline at 12 months. Speech and aesthetics domain scores were comparable at baseline and 12 months.ConclusionPatients reported difficulties with eating and social disruption over the course of 1 year, but problems with speech and appearance abated.
Salvage of postcranioplasty implant exposure using free tissue transfer
Authors: Chou Pang‐Yun , Lin Cheng‐Hung , Hsu Chung‐Chen , Yang Wei‐Hsun , Kane Alex A. , Lin Chih‐Hung 
Published: May 2017

AbstractBackgroundRefractory implant exposure is frustrating after cranioplasty. The purpose of this study was for the authors to present their experience with free tissue transfer for salvage of postcranioplasty implant exposure.MethodsA retrospective medical chart review was conducted on all free tissue transfers performed for exposed implant coverage after cranioplasty between January 2004 and February 2016.ResultsTwelve free flaps were performed in 11 patients who underwent postcranioplasty with implant exposure, and whose attempted implant coverage using locoregional flaps had failed. The free flaps used included anterolateral thigh flap, radial forearm flap, anteromedial thigh and rectus femoris chimeric flap, latissimus dorsi flap, gracilis flap, and Juri flap. The flap survival rate was 100%, and 10 of 11 implants (91%) were salvaged without removal.ConclusionsFree tissue transfer should be considered as the preferred reconstructive option for postcranioplasty exposed implant salvage. High rate of implant salvage (>90%) is possible even with chronic implant exposure (>3 months).
Flow and heat transfer of a Giesekus fluid in plane and 3D ducts
Authors: Al Melhi S. , Filali A. , Khezzar L. , Alshehhi M. 
Published: May 2017

AbstractThis study aims to investigate the Graetz problem of Newtonian and viscoelastic fluid obeying Giesekus model using ANSYS Polyflow solver. The non‐isothermal flow in straight ducts of circular and noncircular cross‐sections under the constant heat flux boundary conditions is considered. The effect of the mobility parameter (α), fluid elasticity defined by Weissenberg number (We) and Reynolds number (Re) on the flow field, secondary flows, and the fully developed and developing Nusselt number along the ducts length are investigated for all geometries. The obtained results are of great importance for practical application in the polymer industries such as polymer melt.
Accelerated melting of PCM in a multitube annulus‐type thermal storage unit using lattice Boltzmann simulation
Authors: Jourabian Mahmoud , Farhadi Mousa , Rabienataj Darzi Ahmad Ali 
Published: May 2017

AbstractMelting of the ice/water as the phase change material in a horizontal single‐tube annulus is sluggish when the stable stratification exists at the bottom of the configuration. To obviate this problem, three heat transfer enhancement techniques could be implemented using the enthalpy‐based lattice Boltzmann method with the double distribution function method to accelerate the process. The multifarious arrangements of the tubes in this horizontal annulus are investigated to expand the region affected by the natural convection. Also, the dispersion of the Cu nanoparticles in the base PCM could boost the thermal conductivity and melting rate. Finally, the metallic porous matrix made of nickel–steel alloys and saturated with the base PCM could be used to enhance the thermal conductivity of the base PCM. The solid–liquid phase change process is defined as the constrained melting of ice‐water in the tube heating mode. There is a thermal equilibrium between ice/water and the nickel–steel porous matrix and the Cu nanoparticles. The Prandtl number, Stefan number, Rayleigh number, and Darcy number are 6.2, 1, 104–105, and 10−3, respectively. The volumetric concentric of the nanoparticles is between 0 and 0.02 and the porosity ranging from 1 to 0.9 in the representative elementary volume scale.
Potential role and prognostic importance of dishevelled‐2 in epithelial ovarian cancer
Authors: Liu Rong , Cheng Jialin , Chen Yannan , Wang Wei , Chen Jie , Mao Guoxin 
Published: May 2017

AbstractObjectiveTo investigate the role and prognostic importance of Dvl2 in human epithelial ovarian cancer (EOC).MethodsA multimethod study was undertaken including patients with pathologically confirmed non‐metastatic EOC who underwent surgery for maximum tumor resection at a center in China. Dvl2 expression was assessed by western blot using fresh EOC tissues and normal ovarian tissues obtained between June 2014 and January 2015. Additionally, retrospective data were obtained for patients treated between April 2004 and September 2009. Their tumor specimens were used in immunohistochemistry analysis. Kaplan–Meier survival plots were constructed to estimate the overall survival by Dvl2 expression, and a Cox proportional hazards model was used to analyze prognostic factors. Alterations in Dvl2 expression during the cell cycle were assessed by a starvation and refeeding assay.ResultsDvl2 expression was higher in EOC samples than in normal tissues on western blot. Overall, 124 patients were included in immunohistochemistry analysis, and Dvl2 expression level was significantly associated with the tumor grade and Ki‐67 expression. Overexpression of Dvl2 was correlated with poor prognosis. The pattern of Dvl2 expression throughout the cell cycle matched that of the cell proliferation marker cyclin D1.ConclusionDvl2 could play a part in EOC progression and might be an independent prognostic factor. Additionally, it might be a prospective therapeutic target in the treatment of EOC.
Network Meta‐Analysis on the Effects of DNA Damage Response‐Related Gene Mutations on Overall Survival of Breast Cancer Based on TCGA Database
Authors: Liu Chang , Chang Hong , Li Xiao‐Han , Qi Ya‐Fei , Wang Jin‐Ou , Zhang Ying , Yang Xiang‐Hong 
Published: May 2017

ABSTRACTThe study was conducted for comparing the effects of 12 DNA damage response gene mutations (CHEK1, CHEK2, RAD51, BRCA1, BRCA2, MLH1, MSH2, ATM, ATR, MDC1, PARP1, and FANCF) on the overall survival (OS) of breast cancer (BC) patients. We searched the Cancer Genome Atlas (TCGA) database from inception to September 2016. Studies that investigated the association between 12 DNA damage responses related genes and BC consolidated into this Network meta‐analysis, by comparing directly or indirectly to evaluate the hazard rate (HR) value and the surface under the cumulative sequence ranking curves (SUCRA). In total four articles were involved. Our results demonstrated 12 DNA damage response gene mutations were associated to the poor prognosis of BC patients (CHEK1: HR = 9.9, 95%CI = 3.6–26.0; CHEK2: HR = 6.9, 95%CI = 3.1–15.0; RAD51: HR = 5.8, 95%CI = 2.2–15.0; BRCA1: HR = 2.8, 95%CI = 1.3–6.1; BRCA2: HR = 3.9, 95%CI = 2.0–7.7; MLH1: HR = 11.0, 95%CI = 3.4–33.0; MSH2: HR = 6.5, 95%CI = 2.1–20.0; ATM: HR = 5.6, 95%CI = 2.6–12.0; ATR: HR = 2.9, 95%CI = 1.3–6.9; MDC1: HR = 15.0, 95%CI = 5.0–45.0; PARP1: HR = 3.4, 95%CI = 1.8–6.6; FANCF: HR = 6.0, 95%CI = 1.8–20.0). SUCRA results revealed that the mutation of MDC1 gene was related to the worst prognosis in patients with BC (SUCRA = 17.32%). DNA damage response gene mutations were associated to the poor prognosis in patients with BC and the BC patients with MDC1 gene mutation had the worst prognosis. J. Cell. Biochem. 118: 4728–4734, 2017. © 2017 Wiley Periodicals, Inc.
LncRNA PTCSC3/miR‐574‐5p Governs Cell Proliferation and Migration of Papillary Thyroid Carcinoma via Wnt/β‐Catenin Signaling
Authors: Wang Xiaoming , Lu Xiubo , Geng Zushi , Yang Guoyu , Shi Yang 
Published: May 2017

ABSTRACTThe distance metastases of papillary thyroid carcinoma (PTC) were a major threaten for PTC patients, thus, to study the potential mechanism for the treatment of PTC was essential. Previous studies have shown that PTCSC3 (Thyroid Carcinoma Susceptibility Candidate 3), miR‐574‐5p and Wnt/β‐catenin were involved in PTC, but the potential pathogenic mechanism among them was still unclear. Real‐time PCR and Western blot were used to detect genes expression. Luciferase reporter assay was used to detect the combination of miR‐574‐5p and suppressor of cancer cell invasion (SCAI), as well as the ratio of TOP/FOP. RNA Pull‐down assay verified the bound of PTCSC3 and miR‐574‐5p. MTT assay, Transwell assay, and wound scratch assay were used to detect cell viability and cell migration. The expression of PTCSC3 and SCAI were decreased, while miR‐574‐5p and β‐catenin were increased in PTC tissues and cells. Overexpressed PTCSC3 suppressed cell proliferation and migration, promoted the expression of SCAI, but inhibited β‐catenin. PTCSC3 absorbed miR‐574‐5p, and miR‐574‐5p targeted to SCAI; SCAI could regulate the activity of Wnt/β‐catenin. PTCSC3/miR‐574‐5p regulated the activity of Wnt/β‐catenin via SCAI and mediated cell proliferation and migration of PTC‐1. In vivo experiments verified the fact that overexpressed PTCSC3 inhibited tumor growth. The signaling PTCSC3‐miR‐574‐5p‐SCAI‐Wnt/β‐catenin mediated the proliferation and migration of PTC‐1 cells, which was vital for the further PTC therapy and prognosis. J. Cell. Biochem. 118: 4745–4752, 2017. © 2017 Wiley Periodicals, Inc.
Effect of Steady‐State Faldaprevir on Pharmacokinetics of Atorvastatin or Rosuvastatin in Healthy Volunteers: A Prospective Open‐Label, Fixed‐Sequence Crossover Study
Authors: Huang Fenglei , Marzin Kristell , Koenen Rüdiger , Kammerer Klaus Peter , Strelkowa Natalja , Elgadi Mabrouk , Quinson Anne‐Marie , Haertter Sebastian 
Published: May 2017

AbstractFaldaprevir (FDV) is a potent, orally administered inhibitor of hepatitis C virus protease. It inhibits multiple cytochrome P‐450 enzymes and multiple membrane transporters. The objective of this study was to evaluate the effect of steady‐state faldaprevir on the pharmacokinetics (PK) of a single dose of atorvastatin or rosuvastatin. In this single‐center, open‐label, fixed‐sequence crossover study, 33 healthy adult male and female volunteers were given either atorvastatin 10 mg (n = 16) or rosuvastatin 10 mg (n = 17) on day 1. Subjects subsequently received 240 mg twice daily of faldaprevir (loading dose) on day 5, followed by 240 mg faldaprevir once daily from day 6 to day 10, with an additional single dose of atorvastatin (10 mg) or rosuvastatin (10 mg) given on day 10. PK samples for the statins were collected on days 1–3 and days 10–12. Concomitant administration with faldaprevir led to approximately 9‐fold and 34‐fold increases in AUC0–∞ and Cmax, respectively, of atorvastatin and approximately 15‐fold and 33‐fold increases in AUC0–∞ and Cmax, respectively, of rosuvastatin, compared with the statins given alone. Exposure to the major metabolites (ortho‐hydroxyatorvastatin and N‐desmethylrosuvastatin) was increased to a similar magnitude as that of the parent compounds. The marked drug–drug interaction observed is most likely related to the inhibitory effects of faldaprevir on transporters, particularly hepatic uptake transporters such as OTAP1B1 and OATP1B3. Given the significant increase in exposure to statins in healthy volunteers, coadministration of faldaprevir with statins should be avoided.
Assessment of nonarteritic anterior ischemic optic neuropathy with intravoxel incoherent motion diffusion‐weighted imaging using readout‐segmented echo‐planar imaging, parallel imaging, and 2D navigator‐based reacquisition
Authors: Lu Ping , Sha Yan , Wan Hailin , Wang Feng , Tian Guohong , Tang Wenlin 
Published: May 2017

PurposeTo determine the feasibility of intravoxel incoherent motion (IVIM) for characterizing perfusion properties and its potential diagnostic utility for nonarteritic anterior ischemic optic neuropathy (NAION). IVIM diffusion‐weighted imaging is a promising technique that can measure perfusion and diffusion characteristics simultaneously in a noninvasive manner.Materials and MethodsOrbital IVIM in a 3.0T scanner was performed on 33 patients with NAION and 15 controls using readout‐segmented echo‐planar imaging, parallel imaging, and 2D navigator‐based reacquisition (RESOLVE‐IVIM). Both visual field (VF) and visual acuity (VA) examinations were performed in 19 of the patients. The vascular volume fraction (f), diffusion coefficient (D), and pseudodiffusion coefficient (D*) were calculated for quantitative analysis. Additionally, correlation analyses of IVIM parameters with visual function were also performed.ResultsAffected optic nerves showed significantly lower f values than both unaffected contralateral nerves of the patients and nerves of the controls (P < 0.0001), and no significant difference for f was found between unaffected contralateral nerves and nerves of the controls (P = 0.1602). In addition, D and D* values showed no significant differences among the three groups (P = 0.0979, 0.0600, 0.6136 for D and 0.1779, 0.6253, 0.4743 for D*). Correlation analysis only demonstrated significant correlations between f values and the mean deviation of the visual field (r = 0.576, P = 0.0051).ConclusionRESOLVE‐IVIM measurement may reflect the perfusion abnormality and visual function impairment in NAION patients, demonstrating its potential application for the diagnosis and clinical evaluation of NAION.Level of Evidence: 1Technical Efficacy: Stage 3J. Magn. Reson. Imaging 2017;46:1760–1766.
Neoformation of pedogenic carbonate and conservation of lithogenic carbonate by farming practices and their contribution to carbon sequestration in soil
Authors: Bughio Mansoor Ahmed , Wang Panlei , Meng Fanqiao , Chen Qing , Li Ji , Shaikh Toqueer A. 
Published: May 2017

AbstractLand use change, tillage practices and straw incorporation are known to affect soil organic carbon (SOC) as well as soil inorganic carbon (SIC) turnover in agricultural soils. SOC and SIC, particularly pedogenic carbonates (PC), were assessed in a semi‐humid region of China to a depth of 160 cm. δ13C values were used to calculate the percentage of PC and lithogenic carbonates (LC) in the total SIC. Over the 39‐y period of intensive agriculture including 14 y of tillage × straw experiment, three treatments, i.e., tillage with wheat and maize straw return (TWM), tillage with wheat straw return (TW), and wheat and maize straw return with no‐tillage (WM) showed an increase of PC compared to a native plantation plot (NP). The significantly higher SOC stock via no‐tillage was limited to top 1 m soil and there was no significant difference between tillage and no‐tillage treatments at 0–160 cm depth. The changes of SOC caused by the tillage and maize straw addition were negligible compared to the gain in PC. Tillage, crop residues incorporation and irrigation played an important role in the turnover of PC and LC. SIC accumulation resulted from combination of neoformation of PC and conservation of LC. Neoformation of silicatic PC sequestered at least 0.49, 0.47, and 0.29 Mg C ha−1 y−1 in TWM, TW, and WM treatments, respectively, with reference to NP plot. We concluded that to evaluate the long term impacts of land use and farming practices on soil C storage, change of pedogenic and lithogenic carbonates and soil organic carbon in deeper soil profiles should be integrated on regional and global scales.
China’s financial system: Resolving the constraints for sustained growth
Authors: Wahed Mohammad Shakil 
Published: May 2017

AbstractAlthough analyses based on recent data suggest that China has made progress in its financial system after 2005, certain areas still require further substantial improvements. While improvements have taken place in areas like non‐performing loans, the legal and regulatory framework, financial deepening and widening, institution building, excessive dominance of the state‐controlled banks over China’s financial system, and the still underdeveloped capital market still need radical reforms. Moreover, the informal financial sector has indeed been a blessing for the Chinese economy, but governing it is of vital importance in order to contain the potential risk elements.
Early neurocognitive improvements following parathyroidectomy for primary hyperparathyroidism
Authors: Shah‐Becker Shivani , Derr Jonathan , Oberman Benjamin S. , Baker Aaron , Saunders Brian , Carr Michele M. , Goldenberg David 
Published: May 2017

ObjectivesTo establish a time frame for postoperative improvements in neurocognitive function in patients who undergo parathyroidectomy for primary hyperparathyroidism by utilizing repeat neuropsychological assessment at multiple time points before and after surgery.Study DesignProspective cohort study.MethodsA prospective study was conducted at a tertiary academic medical center between August 2014 and December 2015, including 50 patients with primary hyperparathyroidism who underwent parathyroidectomy. A panel of neurocognitive tests was administered at two separate time points: preoperative and 1‐week postoperative. Validated neuropsychological assessment tools were utilized, including Rey Auditory‐Verbal Learning Test, Trail Making Test A and B, Benton Controlled Oral Word Association, WAIS‐IV Digit Span, Hospital Anxiety and Depression Scale, Positive and Negative Affect Schedule, and Insomnia Severity Index. Barona Information Sheet was used to collect demographic data. Paired t tests were to compare pre‐ and postoperative scores.ResultsThirty‐five patients completed the preoperative and 1‐week postoperative testing. In cognitive testing, significant improvement was noted in immediate recall (P < 0.001), working memory (P = 0.011), and attention (P = 0.008) at 1‐week postoperative. In mood testing, depression (P < 0.001), anxiety (P < 0.001), and negative affect (P = 0.001) scores were significantly improved at 1‐week postoperative. Insomnia scores also were significantly improved at 1 week (P < 0.001).ConclusionObjective improvements in neurocognitive function following parathyroidectomy for primary hyperparathyroidism were noted as early as 1 week after surgery, which is earlier than previously reported.Level of Evidence2b. Laryngoscope, 128:775–780, 2018
Small dual‐band inverted F antenna using series resonator
Authors: Kim Jae Hee , Ahn Chi‐Hyung 
Published: May 2017

AbstractDesign procedure of a small dual‐band Inverted F Antenna (IFA) using a series resonator is proposed. A series resonator was loaded to the right end of the IFA to make different loading effects according to the resonant frequency of the antenna. When the resonant frequency of the series resonator is between the first and second resonance frequency of the designed antenna, the first resonance has capacitor loading effect while the second resonance has inductor loading effect. These loading effects lead small antenna size at the dual‐band. Both frequency tuning and impedance matching techniques are also proposed. The proposed antenna was simulated and fabricated to be able to resonate at 2.4 GHz and 5.8 GHz and the antenna proved to have had the bandwidth 200 MHz at 2.4 GHz and 400 MHz at 5.8 GHz with the size of 0.12 λ × 0.05 λ. As a result of measuring radiation pattern, maximum efficiency was 88% at 2.4 GHz and 90% at 5.8 GHz.
Bandwidth enhancement of a miniaturized reflectarray antenna using sub‐wavelength meander‐line cells
Authors: Jo Eon‐Seok , Cho Soo‐Bean , Kim Dongho 
Published: May 2017

AbstractWe propose a new way to enlarge gain bandwidth of a miniaturized reflectarray antenna (MRA), a new type of reflectarray antenna (RA) with significantly reduced volume. To extend the gain bandwidth, we have used meander‐line based sub‐wavelength elements as reflectarray cells, which can fully cover a required reflection phase range ideally, 360°. As a result, we have accomplished a three times wider gain bandwidth than that of our previous MRAs. In addition, the proposed MRA can also provide high gain with good aperture efficiency even though a main beam directs toward a tilted direction. Furthermore, remarkably reduced electrical volume, which is 700 times smaller than the smallest conventional RAs, is still maintained. Measured aperture efficiency of the proposed MRA is 41.1% which is comparable with conventional RAs. And the measurement results show that the main lobe direction is very stable around the target direction within the given −1 dB gain bandwidth without any degradation in other performances. As a result, the proposed MRAs with wide gain bandwidth stands out as a good alternative of the conventional RAs.
Split quadrilateral multiband microstrip patch antenna design for modern communication system
Authors: Alam Md. Jubaer , Faruque M. R. I. , Islam M. T. 
Published: May 2017

AbstractIn this article, a mixed split quadrilateral multiband microstrip antenna is designed and its measurement results in terms of different parameters are given. This patch antenna is designed to support modes with resonances at 6.3, 7.1, 7.5, 8.7, 12.8, 17, and 21.3 GHz. FR‐4 (lossy) is used as substrate to design the recommended antenna which has a firm dimension of 11 × 15 mm2 (0.23λ × 0.31λ). This antenna operates at C, X, Ku, and K band with moderate bandwidth because of its design and feedline. This mixed quadrilateral‐shaped multiband antenna has directivity gain of 1.65, 1.26, 2.4, 3.2, 4.57, 4.03, and 3.46 dBi at resonating frequencies and is suitable for a modern communication system. The proposed split multiband quadrilateral antenna results are obtained in terms of return loss, voltage standing wave ratio (VSWR), gain, and radiation pattern which have admissible values of return loss less than −10 dB, VSWR less than 2 at each resonant frequency, and gain more than 3 dB. A suitable radiation pattern and an emerging gain make the recommended antenna suitable for the use in a modern communication system.
Cavity‐backed self‐phased circularly polarized antenna based on stepped‐width dipole with wide axial ratio beamwidth
Authors: Zheng Dong‐Ze , Luo Yu , Chu Qing‐Xin 
Published: May 2017

AbstractA cavity‐backed self‐phased circularly polarized (CP) antenna based on stepped‐width dipoles with wide axial ratio beamwidth is proposed for global positioning system (GPS) applications. The radiator of the antenna consists of two pairs of stepped‐width dipoles, contributing to the CP radiation. The working principle of CP radiation is elaborated by using two simplified models. Then, a feeding network consisting of a Y‐shaped structure and two pairs of identical coplanar striplines (CPSs) is utilized to feed the radiator. Moreover, a cavity‐backed reflector is employed in this antenna to achieve a unidirectional radiation with wide axial ratio (AR) beamwidth. Measured results show that the proposed antenna achieves a wide impedance bandwidth of 43% from 1.37 to 2.12 GHz with Return Loss > 15 dB, and a 3‐dB axial ratio (AR) bandwidth of 6.98% from 1.52 to 1.63 GHz. Particularly, the antenna shows a right‐hand circular polarization (RHCP) radiation with wide 3‐dB AR beamwidth of 205° and 215° in the XOZ and YOZ plane at the center frequency of 1.575 GHz, respectively.