bluuebunny/crossref_metadata_2025_split huggingface dataset:
Closing Remarks
Authors: Rimmerman Arie 
Published: September 2024

Abstract
Digitalization has changed society and reconfigured social relationships, and thus the dynamics and climate of inclusion. This chapter introduces five themes that are aimed at revisiting the issue of the social inclusion of people with disabilities. The first is the recognition that social inclusion has shifted toward digital inclusion, primarily during the COVID-19 pandemic. The second theme relates to the vulnerability of people with disabilities during the pandemic, as they can be digitally and socially excluded. The third theme is the need for governments to revise the policies toward people with disabilities after the pandemic. The fourth is related to children with disabilities and how authorities need to promote inclusive policies toward them and their households after the pandemic. The fifth theme sheds light on the status of social and digital exclusion of people with disabilities who live in low- and middle-income countries and the need to revise policies.
Aesthetic Ideas and Art Interpretation in Kant’s Third Critique and Schelling’s ‘System of Transcendental Idealism’
Authors: Erkan Ekin 
Published: September 2024

Abstract
This paper argues for a metacognitive reading of Kant’s doctrine of ‘aesthetic ideas’, according to which they enjoy the functional role of licensing a theory of art interpretation. I begin by offering a textualist reading of Kant’s doctrine of ‘aesthetic ideas’ and contest the received ‘semantic paradigm’ according to which aesthetic ideas either approximate the form or content of a rational idea. After showing the relationship between aesthetic ideas and artistic interpretation, I assess whether Kant’s theory delivers what we want from a theory of artistic interpretation. I subsequently show how Schelling’s conception of artistic production and reception in the System of Transcendental Idealism (1800) draws from Kant’s doctrine of ‘aesthetic ideas’. After analyzing the relationship between Kant and Schelling’s accounts of art interpretation, I evaluate which account we ought to prefer.
Replacing sperm with genotyped haploid androgenetic blastomeres to generate cattle with predetermined paternal genomes
Authors: Aguila Luis , Sampaio Rafael V , Therrien Jacinthe , Nociti Ricardo P , Labrecque Remi , Tremblay Amelie , Marras Gabrielle , Blondin Patrick , Smith Lawrence C 
Published: September 2024

Abstract

Although meiosis plays an essential role for the survival of species in natural selection, the genetic diversity resulting from sexual reproduction impedes human-driven strategies to transmit the most suitable genomes for genetic improvement, forcing breeders to select diploid genomes generated after fertilization, that is, after the encounter of sperm and oocytes carrying unknown genomes. To determine whether genomic assessment could be used before fertilization, some androgenetic haploid morula-stage bovine embryos derived from individual sperm were biopsied for genomic evaluation and others used to reconstruct “semi-cloned” (SC) diploid zygotes by the intracytoplasmic injection into parthenogenetically activated oocytes, and the resulting embryos were transferred to surrogate females to obtain gestations. Compared to controls, in vitro development to the blastocyst stage was lower and fewer surrogates became pregnant from the transfer of SC embryos. However, fetometric measurements of organs and placental membranes of all SC conceptuses were similar to controls, suggesting a normal post-implantation development. Moreover, transcript amounts of imprinted genes IGF2, IGF2R, PHLDA2, SNRPN, and KCNQ1OT1 and methylation pattern of the KCNQ1 DMR were unaltered in SC conceptuses. Overall, this study shows that sperm can be replaced by genotyped haploid embryonic-derived cells to produce bovine embryos carrying a predetermined paternal genome and viable first trimester fetuses after transfer to female recipients.

Summary Sentence
Haploid morula-stage embryonic cells derived from a single sperm can be genotyped and injected into activated oocytes to reconstruct diploid zygotes that develop both in vitro into blastocysts and in vivo into viable post-implantation bovine conceptuses with predetermined paternal genomes.
Interaction of motor behaviour, cortical oscillations and deep brain stimulation in Parkinson’s disease
Authors: Mirpour Koorosh , Pouratian Nader 
Published: September 2024

Abstract
Recent progress in the study of Parkinson’s disease has highlighted the pivotal role of beta oscillations within the basal ganglia-thalamo-cortical network in modulating motor symptoms. Predominantly manifesting as transient bursts, these beta oscillations are central to the pathophysiology of Parkinson’s disease motor symptoms, especially bradykinesia. Our central hypothesis is that increased bursting duration in cortex, coupled with kinematics of movement, disrupts the typical flow of neural information, leading to observable changes in motor behaviour in Parkinson’s disease.
To explore this hypothesis, we employed an integrative approach, analysing the interplay between moment-to-moment brain dynamics and movement kinematics and the modulation of these relationships by therapeutic deep brain stimulation (DBS). Local field potentials were recorded from the hand motor (M1) and premotor cortical (PM) areas and internal globus pallidus (GPi) in 26 patients with Parkinson’s disease undergoing DBS implantation surgery. Participants executed rapid alternating hand movements in 30-s blocks, both with and without therapeutic pallidal stimulation.
Behaviourally, the analysis revealed bradykinesia, with hand movement cycle width increasing linearly over time during DBS-OFF blocks. Crucially, there was a moment-to-moment correlation between M1 low beta burst duration and movement cycle width, a relationship that dissipated with therapeutic DBS. Further analyses suggested that high gamma activity correlates with enhanced motor performance with DBS-ON. Regardless of the nature of coupling, DBS’s modulation of cortical bursting activity appeared to amplify the brain signals’ informational content regarding instantaneous movement changes.
Our findings underscore that DBS significantly reshapes the interaction between motor behaviour and neural signals in Parkinson’s disease, not only modulating specific bands but also expanding the system’s capability to process and relay information for motor control. These insights shed light on the possible network mechanisms underlying DBS therapeutic effects, suggesting a profound impact on both neural and motor domains.
Laminar organization of visual responses in core and parabelt auditory cortex
Authors: Mackey Chase A , O’Connell Monica N , Hackett Troy A , Schroeder Charles E , Kajikawa Yoshinao 
Published: September 2024

Abstract
Audiovisual (AV) interaction has been shown in many studies of auditory cortex. However, the underlying processes and circuits are unclear because few studies have used methods that delineate the timing and laminar distribution of net excitatory and inhibitory processes within areas, much less across cortical levels. This study examined laminar profiles of neuronal activity in auditory core (AC) and parabelt (PB) cortices recorded from macaques during active discrimination of conspecific faces and vocalizations. We found modulation of multi-unit activity (MUA) in response to isolated visual stimulation, characterized by a brief deep MUA spike, putatively in white matter, followed by mid-layer MUA suppression in core auditory cortex; the later suppressive event had clear current source density concomitants, while the earlier MUA spike did not. We observed a similar facilitation-suppression sequence in the PB, with later onset latency. In combined AV stimulation, there was moderate reduction of responses to sound during the visual-evoked MUA suppression interval in both AC and PB. These data suggest a common sequence of afferent spikes, followed by synaptic inhibition; however, differences in timing and laminar location may reflect distinct visual projections to AC and PB.
A case report of systemic lupus erythematosus with severe pulmonary hypertension presenting as large pericardial effusion with early signs of cardiac tamponade: a diagnostic and therapeutic challenge
Authors: Alghamdi Abdullah Ibrahim , Shah Muhammad Azam , Alkhodair Abdullah Mohammed 
Published: September 2024

Abstract

Background
Pulmonary hypertension is defined as resting arterial pressure &gt;20 mmHg. Cardiac tamponade is a medical emergency where fluids accumulate in the pericardial sac compressing the heart pericardium leading to heart failure. Pericardiocentesis is challenging in patients with cardiac tamponade and severe pulmonary hypertension due to the risk of catastrophic haemodynamic collapse.

Case Summary
An 18-year-old female who was recently diagnosed to have systemic lupus erythematosus (SLE) presented to the emergency department with shortness of breath, chest pain, fever, and fatigue. The physical examination revealed tachycardia, muffled heart sounds, and distended jugular venous pulse. Chest X-ray showed cardiomegaly, and transthoracic echocardiography showed a large circumferential pericardial effusion with signs of cardiac tamponade. There was severe pulmonary hypertension along with a dilated right ventricle with systolic dysfunction. The right ventricular systolic pressure was around 100 mmHg. The multidisciplinary team of cardiologists and pulmonologists decided to avoid pericardiocentesis due to the high risk of haemodynamic collapse. Aggressive medical therapy targeting pulmonary hypertension and SLE was started, which resulted in complete resolution of the pericardial effusion and normalization of pulmonary artery pressure.

Discussion
A conservative approach can be an alternative strategy to manage patients with large pericardial effusion and impending pericardial tamponade in the presence of severe pulmonary arterial hypertension as pericardiocentesis carries a high risk of haemodynamic collapse.
Steroid-resistant immunoglobulin G4–related coronary arteritis: a case report
Authors: Okada Tomoaki , Takagi Wataru , Nosaka Kazumasa , Doi Masayuki 
Published: September 2024

Abstract

Background
Immunoglobulin G4 (IgG4)–related diseases are systemic fibroinflammatory disease characterized by extensive infiltration of IgG4-positive plasma cells in the affected tissue(s), with high plasma levels of IgG4. However, coronary involvement is rare.

Case summary
A 70-year-old man was diagnosed with IgG4-related coronary arteritis, pancreatitis, and cholangitis during full-body contrast computed tomography (CT) examination prior to surgery for an iliac artery aneurysm. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/CT showed increased uptake of 18F-FDG in the pancreas, extrahepatic bile ducts, and proximal right coronary artery (RCA). Despite the patient being asymptomatic, the RCA showed severe stenosis. The patient was administered a conservative treatment with prednisolone, 30 mg/day, gradually tapered to 5 mg/day, for 6 months. Two years later, contrast CT showed improvement of the pancreatic and bile duct lesions; however, the steroid therapy had not improved the coronary artery lesions, and gradual progression of the lesions was observed. Percutaneous coronary intervention was performed with a cutting balloon in the RCA, and good patency was maintained for 1 year after the procedure.

Discussion
Steroid therapy is the first-line treatment for IgG4-related diseases; however, there may be some refractory cases. The stenotic and aneurysmal types of IgG4-related coronary arteritis are life-threatening; therefore, we performed revascularization using balloon angioplasty. Determining the optimal revascularization technique for drug-refractory cases requires further investigation.
Management and follow-up strategies for patients with head and neck paraganglioma
Authors: Richter Susan , Pacak Karel , Kunst Henricus P M , Januszewicz Andrzej , Nölting Svenja , Remde Hanna , Robledo Mercedes , Eisenhofer Graeme , Timmers Henri J L M , Pamporaki Christina 
Published: September 2024

Abstract

Objective
Head-neck paragangliomas (HNPGLs) are rare tumors with approximately half arising due to germline pathogenic variants (PVs) in succinate dehydrogenase genes (SDHx). Patients with HNPGL have heterogeneous propensity to recur and metastasize. Thus, we aim to assess prevalence and predictors of recurrent (RD) and/or metastatic disease in patients with and without SDHx-related HNPGLs.

Design and methods
This cross-sectional study used retrospective data of 214 patients enrolled in six referral centers. Data included sex, age, primary tumor treatment, location, and size, biochemical phenotype, germline PVs, presence of RD (locoregional or new tumor), and/or metastasis.

Results
Patients with and without SDHx-related HNPGLs showed 74% and 40% prevalence of RD, respectively. Patients without SDHx-related HNPGLs presented with recurrent tumors only in head-neck regions. The only independent predictor for RD in the entire cohort was presence of SDHx PVs. Metastatic prevalence reached 9%-13%. For patients with SDHx-related HNPGLs, large tumor size (&gt;2.3 cm, OR:50.0, CI:2.6-977.6), young age at initial diagnosis (&lt;42years, OR:27.3, CI:1.8-407.2), and presence of SDHB PV (OR:15.6; CI:1.5-164.8) were independent predictors of metastasis. For patients without SDHx-related HNPGLs, only carotid-body location was an independent predictor of metastasis (OR:18.9, CI:2.0-182.5).

Conclusions
Patients without SDHx-related HNPGLs require long-term follow-up due to high prevalence of RD with imaging largely restricted to head-neck regions. As carotid-body HNPGLs have the highest metastatic risk among sporadic tumors, radical treatment with frequent follow-up is suggested until population-based data are available. Importantly, patients with SDHx-related HNPGLs might benefit from early radical treatment when tumors are still small to reduce metastatic risk.
International youth literature in the Chinese EFL classroom
Authors: Sun Lina , Zhang Wenzhong 
Published: September 2024

Abstract
This qualitative case study examines the role of international youth literature in enhancing the English language learning and global competence of Chinese university students. Through engaging in meaningful literacy activities, this study reveals the potential of a critical-global-literacies-based approach to foster cultural sensitivity and global awareness. By investigating how students gained knowledge of cultural diversity and developed a critical understanding of our interconnected world, this paper advocates for a dynamic approach to literature-oriented English language education, thus prompting a paradigm shift in teaching practices.
Does brain size of Asiatic toads (Bufo gargarizans) trade-off with other energetically expensive organs along altitudinal gradients?
Authors: Yao Zhongyi , Huang Kun , Qi Yin , Fu Jinzhong 
Published: September 2024

Abstract
Brain size variation is often attributed to energetic trade-offs with other metabolically expensive tissues and organs, which is a prediction of the expensive brain hypothesis (EBH). Here we examine Asiatic toads (Bufo gargarizans) along altitudinal gradients and test size trade-offs between the brain and four visceral organs (heart, liver, alimentary tract, and kidney) with altitude. Body size and scaled mass index (a proxy for total energy intake) decline with altitude, implying stronger energetic constraints at high altitudes. Relative brain size decreases along altitudinal gradients, while visceral organs mostly increase in relative sizes. Using structural equation modeling, a significant negative relationship between brain size and a latent variable “budget,” which represents the energy allocation to the four visceral organs, is detected among high-altitudinal toads. Heart appears to have the largest and most consistent response to changes in energy allocation. No such relationships are observed among toads at middle- and low-altitudes, where high energy intake may allow individuals to forego energetic trade-offs. When applying EBH to poikilotherms, a great emphasis should be placed on total energy intake in addition to energy allocation. Future research on EBH will benefit from more intra-specific comparisons and the evaluation of fitness consequences beyond energy limitation.
Care seeking during pregnancy: testing the assumptions behind service delivery redesign for maternal and newborn health in rural Kenya
Authors: Croke Kevin , Kapaon David , Opondo Kennedy , Cooper Jan , Nzinga Jacinta , Olwanda Easter , Rahim Nicholas , Kruk Margaret E 
Published: September 2024

Abstract
A health systems reform known as Service Delivery Redesign (SDR) for maternal and newborn health seeks to make high-quality delivery care universal in Kakamega County, in western Kenya, by strengthening hospital-level care and making hospital deliveries the default option for pregnant women. Using a large prospective survey of new mothers in Kakamega County, we examine several key assumptions that underpin the SDR policy’s theory of change. We analyse data on place of delivery, travel time and distance, out-of-pocket spending, and self-reported quality of care for 19 127 women prospectively enrolled during antenatal care (ANC) and surveyed two times after their delivery. We analyze changes in womens’ delivery location preferences in recent years in Kakamega, and over the course of their most recent pregnancy. We also evaluate travel time, out-of-pocket expenditures and patient satisfaction for women who deliver in public hospitals vs primary health centres. We find substantial changes in delivery location at the population level over time and for individual women over the course of pregnancy. Facility delivery has increased from 50.4% in 2010 to 89.5% in 2019; 70% of respondents deliver at a different facility than their reported intention at ANC. Out-of-pocket delivery expenditures are on average 1351 Kenyan shillings (Ksh) in hospitals compared to 964 Ksh in PHC (primary health care)s (P &lt; 0.01). Transport expenditures are 337 Ksh for PHC level deliveries vs 422 Ksh for hospitals (P &lt; 0.01). Self-reported average travel time is 51 min (PHC delivery) vs 47 min (hospital delivery) (P = 0.78). The average distance to a delivery location is 15.1 km for PHC deliveries vs 15.2 km for hospitals (P = 0.99). There were no differences in overall patient-reported quality scores, while some subcomponents of quality favoured hospitals. These findings support several key assumptions of the SDR theory of change in Kakamega County, while also highlighting important challenges that should be addressed to increase the likelihood of successful implementation.
Edward Long’s observations on Jamaican slavery and British slave trade abolition
Authors: Morgan Kenneth 
Published: September 2024

Abstract
This note presents for the first time material on Edward Long’s views on Jamaican enslavement and British slave trade abolition in 1804. His letter of that year, deposited at the William Salt Library, Stafford, shows that in old age he adapted his position from being an ardent slave trade supporter to a stance where ending the slave trade could be accepted. Long emphasized that, in circumstances where slave revolt and Jamaica’s security were concerned, the pro-slave trade argument would need to be shelved, the implementation of abolition would be acceptable and planters could then concentrate their efforts on amelioration.
Investigating MATN3 and ASPN as novel drivers of gastric cancer progression via EMT pathways
Authors: Li Jing , Xie Bo , Wang Hu , Wang QingKang , Wu YongYou 
Published: September 2024

Abstract
Gastric cancer (GC) is a leading cause of cancer-related deaths globally, necessitating the identification of novel therapeutic targets. This study investigates the roles of MATN3 and ASPN in GC progression via the epithelial-mesenchymal transition (EMT) pathway. Analysis of the Cancer Genome Atlas—Stomach Adenocarcinoma (TCGA-STAD) dataset revealed that both MATN3 and ASPN are significantly upregulated in GC tissues and correlate with poor patient survival. Protein–protein interaction and co-expression analyses confirmed a direct interaction between MATN3 and ASPN, suggesting their synergistic role in EMT activation. Functional assays demonstrated that MATN3 promotes GC cell proliferation, migration, and invasion, while its knockdown inhibits these malignant behaviors and induces apoptosis. ASPN overexpression further amplified these oncogenic effects. In vivo, studies in a mouse model corroborated that co-overexpression of MATN3 and ASPN enhances tumor growth and metastasis. These findings highlight the MATN3-ASPN axis as a potential therapeutic target in GC, offering new insights into the molecular mechanisms driving GC progression.
Gravitational Instantons, Weyl Curvature, and Conformally Kähler Geometry
Authors: Biquard Olivier , Gauduchon Paul , LeBrun Claude 
Published: September 2024

Abstract
In a previous paper [7], the first two authors classified complete Ricci-flat ALF Riemannian 4-manifolds that are toric and Hermitian, but non-Kähler. In this article, we consider general Ricci-flat metrics on these spaces that are close to a given such gravitational instanton with respect to a norm that imposes reasonable fall-off conditions at infinity. We prove that any such Ricci-flat perturbation is necessarily Hermitian and carries a bounded, non-trivial Killing vector field. With mild additional hypotheses, we are then able to show that the new Ricci-flat metric must actually be one of the known gravitational instantons classified in [7].
Introduction to the Presidential Special Issue
Authors: Chenoweth Erica , Parashar Swati 
Published: September 2024

Abstract
This Presidential Special Issue brings together a diverse array of scholars and perspectives to address contemporary challenges to the world—and to international studies. Drawing together contributions from the Sapphire Series and the 2023 International Studies Association Annual Meeting, contributors grapple with uncertainty, complexity, and the imperative of inclusivity in the field and beyond.
Impact of wearable device data and multi-scale entropy analysis on improving hospital readmission prediction
Authors: Nagarajan Vishal , Shashikumar Supreeth Prajwal , Malhotra Atul , Nemati Shamim , Wardi Gabriel 
Published: September 2024

Abstract

Objective
Unplanned readmissions following a hospitalization remain common despite significant efforts to curtail these. Wearable devices may offer help identify patients at high risk for an unplanned readmission.

Materials and Methods
We conducted a multi-center retrospective cohort study using data from the All of Us data repository. We included subjects with wearable data and developed a baseline Feedforward Neural Network (FNN) model and a Long Short-Term Memory (LSTM) time-series deep learning model to predict daily, unplanned rehospitalizations up to 90 days from discharge. In addition to demographic and laboratory data from subjects, post-discharge data input features include wearable data and multiscale entropy features based on intraday wearable time series. The most significant features in the LSTM model were determined by permutation feature importance testing.

Results
In sum, 612 patients met inclusion criteria. The complete LSTM model had a higher area under the receiver operating characteristic curve than the FNN model (0.83 vs 0.795). The 5 most important input features included variables from multiscale entropy (steps) and number of active steps per day.

Discussion
Data available from wearable devices can improve ability to predict readmissions. Prior work has focused on predictors available up to discharge or on additional data abstracted from wearable devices. Our results from 35 institutions highlight how multiscale entropy can improve readmission prediction and may impact future work in this domain.

Conclusion
Wearable data and multiscale entropy can improve prediction of a deep-learning model to predict unplanned 90-day readmissions. Prospective studies are needed to validate these findings.