bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ancient Maya and the modern forest
Authors: Brokaw Nicholas , Ward Sheila E. , Beach Timothy , Luzzadder‐Beach Sheryl , Walling Stanley , Cortes‐Rincon Marisol , Valdez Fred 
Published: September 2024

AbstractThe land use of the ancient Maya strongly affected the environment of the previously forested Maya Lowlands. A forest grew back after the Maya “collapse”, some 1100 years ago. Two activities of the ancient Maya could have had widespread effects on the tree species composition of the regrown, modern forest. First, in areas with topographic relief Maya agriculture caused substantial soil erosion and accumulation, changing soil depth and character. Soil character is associated with differential distributions and abundances of many tree species in the Maya Lowlands. To the extent that soil character on the modern landscape differs from that on the pre‐Maya landscape, regrown forests on the modern landscape would differ from pre‐Maya forests. Second, the ancient Maya cleared much forest but likely also cultivated or favored certain tree species in home gardens, regenerating farm plots, and patches of older growth. A rigorous study suggests that descendants of favored tree species persist in elevated abundance in some areas of the modern forest but not in other areas. After c. 1100 years of regrowth in some places, the legacy of the ancient Maya in the modern forest likely ranges from strong to absent across the varied landscape of the Lowlands. An ancient mosaic of forest patches would have provided a species‐rich, multiple‐point source for forest regrowth. Such a mosaic is lacking in modern deforested tropical landscapes, likely inhibiting recovery of a species‐rich forest.
Topical Anti‐Inflammatory Treatments for Eczema: A Cochrane Systematic Review and Network Meta‐Analysis
Authors: Lax Stephanie J. , Van Vogt Eleanor , Candy Bridget , Steele Lloyd , Reynolds Clare , Stuart Beth , Parker Roses , Axon Emma , Roberts Amanda , Doyle Megan , Chu Derek K. , Futamura Masaki , Santer Miriam , Williams Hywel C. , Cro Suzie , Drucker Aaron M. , Boyle Robert J. 
Published: September 2024

ABSTRACTObjectiveEczema is the most burdensome skin condition worldwide and topical anti‐inflammatory treatments are commonly used to control symptoms. The relative effectiveness and safety of different topical anti‐inflammatory treatments is uncertain.DesignNetwork meta‐analysis performed within a Cochrane systematic review to compare and statistically rank efficacy and safety of topical anti‐inflammatory eczema treatments.Data SourcesCochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase and trial registries to June 2023.Eligibility Criteria for Selected TrialsIncluded trials were within‐participant or between‐participant randomised controlled trials. Participants had eczema that was not clinically infected and was not contact dermatitis, seborrheic eczema or hand eczema. Interventions were topical anti‐inflammatory treatments but not complementary treatments, antibiotics alone, wet wraps, phototherapy or systemic treatments. Comparators were no treatment/vehicle or another topical anti‐inflammatory.ResultsWe identified 291 trials (45,846 participants), mainly in high‐income countries. Most were industry‐funded with median 3 weeks treatment duration. Risk of bias assessed using the Cochrane Risk of Bias 2.0 tool was high in 89% of trials, mainly due to risk of selective reporting. Network meta‐analysis of binary outcomes ranked potent and/or very potent topical steroids, tacrolimus 0.1% and ruxolitinib 1.5% among the most effective treatments for improving patient‐reported symptoms (40 trials, all low confidence) and clinician‐reported signs (32 trials, all moderate confidence). For investigator global assessment, the Janus kinas inhibitors ruxolitinib 1.5%, delgocitinib 0.5% or 0.25%, very potent/potent topical steroids and tacrolimus 0.1% were ranked as most effective (140 trials, all moderate confidence). Continuous outcome data were mixed. Local application site reactions were most common with tacrolimus 0.1% (moderate confidence) and crisaborole 2% (high confidence) and least common with topical steroids (moderate confidence). Skin thinning was not increased with short‐term use of any topical steroid potency (low confidence) but skin thinning was reported in 6/2044 (0.3%) participants treated with longer‐term (6–60 months) topical steroids.ConclusionPotent topical steroids, Janus kinase inhibitors and tacrolimus 0.1% were consistently ranked as among the most effective topical anti‐inflammatory treatments for eczema.
Multiple congenital anomalies in two fetuses with glutathione‐synthetase deficit (GSS)
Authors: Jury Jeanne , Benoist Jean‐François , Joubert Madeleine , Quelin Chloé , Besnard Thomas , Conrad Solène , Le Vaillant Claudine , Bézieau Stéphane , Isidor Bertrand , Attié‐Bitach Tania , Cogné Benjamin , Vincent Marie 
Published: September 2024

AbstractGlutathione synthetase deficiency is a rare inborn metabolic disease usually caused by biallelic variants in GSS. Clinical severity varies from isolated hemolytic anemia, sometimes associated with chronic metabolic acidosis and 5‐oxoprolinuria, to severe neurological phenotypes with neonatal lethality. Here we report on two fetal siblings from two pregnancies with glutathione synthetase deficiency exhibiting similar multiple congenital anomalies associating phocomelia, cleft palate, intra‐uterine growth retardation, genito‐urinary malformations, and congenital heart defect. Genome sequencing showed that both fetuses were compound heterozygous for two GSS variants: the previously reported pathogenic missense substitution NM_000178.4 c.800G>A p.(Arg267Gln), and a 2.4 kb intragenic deletion NC_000020.11:g.34944530_34946833del. RNA‐seq on brain tissue revealed the out‐of‐frame deletion of the exon 3 and an almost monoallelic expression of the missense variant (88%), suggesting degradation of the deletion‐harboring allele by nonsense‐mediated mRNA decay. 5‐oxoproline (pyroglutamic acid) levels in amniotic fluid were elevated, suggesting an alteration of the gamma‐glutamyl cycle, and corroborating the pathogenicity of the two GSS variants. Only one case of glutathione synthetase deficiency with limb malformations has previously been reported, in a newborn homozygous for the c.800G>A variant. Thus, our data allow us to discuss a potential phenotypic extension of glutathione synthetase deficiency, with a possible involvement of the c.800G>A variant.
Fathers' transformative caring experiences of engaging in music and singing with their children
Authors: Damsgaard Janne Brammer , Dyring Rasmus , Brinkmann Svend 
Published: September 2024

AbstractThis study explores the role of music and singing in fostering transformative caring relationships between fathers and their children. It aims to understand how these interactions contribute to fatherhood identity and relational dynamics, filling a significant gap in research on musical fatherhood. Employing a phenomenological‐hermeneutic approach, the study conducted open‐ended interviews with eight fathers, analysing data through the lens of Paul Ricoeur's theory of interpretation. Findings reveal that musical activities enable fathers to engage intuitively and responsively with their children, facilitating a pre‐verbal form of communication that deepens emotional bonds and enhances paternal identity. Music and singing emerge as powerful tools that transcend traditional parenting roles, allowing fathers to experience and express a potentiated sense of fatherhood marked by empathy, connection and care. This study highlights the profound impact of musical engagement on father–child relationships and suggests broader implications for emotional intelligence and gender roles in parenting.
CircSMAD3 represses VSMC phenotype switching and neointima formation via promoting hnRNPA1 ubiquitination degradation
Authors: Mei Shuai , Ma Xiaozhu , Zhou Li , Wuyun Qidamugai , Cai Ziyang , Yan Jiangtao , Ding Hu 
Published: September 2024

AbstractCircular RNAs (circRNAs) are novel regulatory RNAs with high evolutionary conservation and stability, which makes them effective therapeutic agents for various vascular diseases. The SMAD family is a downstream mediator of the canonical transforming growth factor beta (TGF‐β) signalling pathway and has been considered as a critical regulator in vascular injury. However, the role of circRNAs derived from the SMAD family members in vascular physiology remains unclear. In this study, we initially identified potential functional circRNAs originating from the SMAD family using integrated transcriptome screening. circSMAD3, derived from the SMAD3 gene, was identified to be significantly downregulated in vascular injury and atherosclerosis. Transcriptome analysis was conducted to comprehensively illustrate the pathways modulated by circRNAs. Functionally, circSMAD3 repressed vascular smooth muscle cell (VSMC) proliferation and phenotype switching in vitro evidenced by morphological assays, and ameliorated arterial injury‐induced neointima formation in vivo. Mechanistically, circSMAD3 interacted with heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) within the nucleus, enhanced its interaction with E3 ligase WD repeat domain 76 to promote hnRNPA1 ubiquitination degradation, facilitated p53 pre‐RNA splicing, activated the p53γ signalling pathway, and finally suppressed VSMC proliferation and phenotype switching. Our study identifies circSMAD3 as a novel epigenetic regulator that suppresses VSMC proliferation and phenotype switching, thereby attenuating vascular remodelling and providing a new circRNA‐based therapeutic strategy for cardiovascular diseases.
Education for Robust Self‐Respect in an Unjust World†
Authors: Li Shiying 
Published: September 2024

AbstractPhilosophical work on self‐respect has distinguished between various kinds of self‐respect. In this paper, Shiying Li begins by introducing important kinds of self‐respect and exploring the conceptual and empirical relations among them. She then discusses the value and political significance of social bases of self‐respect for both individuals and society. While political theory on this topic, especially from the Rawlsian tradition, has focused on the social bases of self‐respect in a well‐ordered society, Li takes on the task of uncovering the social bases of self‐respect in an unjust society marked by structural injustices such as racism, sexism, social stigmas, and economic and other social inequalities. She provides arguments, including public reason arguments, for the political priority and urgency of securing robust self‐respect for all in an unjust society, and thus paves the way for a discussion of the role that education, especially schooling, can and should play in securing robust self‐respect. Li concludes by offering reasons to direct special attention to specific aspects of schooling and by making suggestions regarding a curriculum and pedagogy aimed at securing robust self‐respect for all.
Buoyancy and vertical distribution of haddock (Melanogrammus aeglefinus) eggs during embryonic development: A comparison with cod (Gadus morhua)
Authors: Stenevik Erling Kåre , Sundby Svein , Ådlandsvik Bjørn , Thorsen Anders 
Published: September 2024

AbstractVertical egg distributions are needed knowledge for understanding exposure to physical forcing, predation pressure, and modelling initial transport from the spawning areas. Egg density and size are the biotic factors determining vertical distributions while the ambient salinity and turbulent mixing are the physical factors contributing to their vertical distributions. Egg buoyancies and densities of Atlantic cod (Gadus morhua) have been extensively studied, while limited information on haddock (Melanogrammus aeglefinus) egg density is available. This is the first comprehensive study on haddock egg densities in Norwegian waters. Eggs were collected from pairs of spawning fish caught at the coast of western Norway and inserted into a density gradient column where density was measured. The haddock eggs were neutrally buoyant at salinities ranging from 28.5 to 31. The density changed during egg development, and the results from the measurements were used to model the vertical distribution of the eggs. The simulations showed that the changes in buoyancy substantially affected vertical distributions. A comparison to previously published data on cod eggs showed that haddock eggs are considerably more buoyant than the cod eggs and are—particularly during calm wind conditions—confined to the surface layer to a larger extent than the cod eggs. The more buoyant attribute of the haddock eggs, together with the lipophilic surface of the egg membrane, is suggested to make haddock eggs more vulnerable to buoyant pollutants, like hydrocarbons.
Sex differences in the clinical manifestations and treatment outcomes in a large cohort of spontaneous intracranial hypotension
Authors: Lin Po‐Tso , Hseu Shu‐Shya , Fuh Jong‐Ling , Lirng Jiing‐Feng , Chen Shih‐Pin , Chen Wei‐Ta , Wang Shuu‐Jiun , Wang Yen‐Feng 
Published: September 2024

AbstractObjectiveTo determine sex differences in clinical profiles and treatment outcomes in patients with spontaneous intracranial hypotension.BackgroundSpontaneous intracranial hypotension is associated with considerable functional disability and potentially fatal complications, and it is uncertain whether males and females should be managed differently.MethodsThis was a cohort study of consecutive patients with spontaneous intracranial hypotension enrolled from a medical center. Medical records and imaging findings were reviewed. The outcome of treatment responses to epidural blood patches and risks of subdural hematoma were measured.ResultsIn total, 442 patients with spontaneous intracranial hypotension (165 males, 277 females) were included in the analysis. Males were more likely to have a delayed (>30 days) initial presentation than females (32.1% [53/165] vs. 19.9% [55/277], p = 0.004), and males were less likely to have nausea (55.8% [92/165] vs. 67.1% [186/277], p = 0.016), vomiting (43.0% [71/165] vs. 54.2% [150/277], p = 0.024), photophobia (9.7% [16/165] vs. 17.0% [47/277], p = 0.034), and tinnitus (26.7% [44/165] vs. 39.7% [110/277], p = 0.005) compared with females despite comparable radiologic findings. Among the 374 patients treated with epidural blood patches, males were more likely to be nonresponders to the first epidural blood patch (58.0% [80/138] vs. 39.0% [92/236], OR = 2.2, 95% CI = 1.4–3.3, p < 0.001). Males were at a higher risk of having subdural hematoma (29.7% [49/165] vs. 10.8% [30/277], OR = 3.5, 95% CI = 2.1–5.8, p < 0.001). Among patients with subdural hematoma, males had greater thickness (12.8 ± 4.3 vs. 8.1 ± 5.9 mm, p < 0.001) and were more likely to receive surgical drainage (55.1% [27/49] vs. 10.0% [3/30], OR = 11.0, 95% CI = 3.0–41.3, p < 0.001) than females.ConclusionIn the present study, spontaneous intracranial hypotension in males was characterized by a delayed presentation, poorer response to the first epidural blood patch, and a higher risk of subdural hematoma. Caution should be exercised in the management of males with spontaneous intracranial hypotension. The generalizability of the findings needs to be further confirmed.
Pornography consumption and its effect on sexual performance in young men: Urology point of view
Authors: Lucumi Yorlavi , Nieva‐Posso Daniel Andrés , García‐Perdomo Herney Andrés 
Published: September 2024

AbstractChronic pornography use is a public health problem that has considerable effects on men's health, especially on their sexual performance, having effects that can be encompassed from a biological, social, and psychological approach. Our objective was to conduct a literature review to evaluate the consequences in terms of sexual performance of young men who have chronic consumption of pornography. Chronic pornography consumption was related to erectile dysfunction, premature ejaculation, and alterations in genital anatomy and physiology. Social and psychological effects were also found, such as increased rates of violence towards women, problems with partners, and intimacy. However, benefits of controlled consumption of pornography have also been identified, such as reaffirmation of sexual orientation, stimulation of self‐discovery of the body, and improved communication with partners. Chronic consumption of pornography has direct effects on the sexual performance of young people and should be evaluated by a multidisciplinary team that includes physiological, social, and psychological elements. However, its use may be recommended for people with psychological problems, urological problems, and urological cancer.
Belief in conspiracy theories and satisfaction in interpersonal relationships
Authors: Toribio‐Flórez Daniel , Green Ricky , Douglas Karen M. 
Published: September 2024

AbstractResearchers have theorized about how belief in conspiracy theories can negatively affect interpersonal relationships. However, despite growing anecdotal evidence of the effects that conspiracy theories seem to have on people's relationships, a systematic assessment of these effects is lacking. In seven studies (six of them preregistered, N = 2526), we examined whether people's perceptions of others' conspiracy beliefs were negatively associated with their actual (or anticipated) relationship satisfaction with those others. We found that participants' perceptions of their social contacts' beliefs in general (Pilot Studies 1–2) and specific conspiracy theories (Study 1) were negatively associated with their relationship satisfaction with those contacts. Using a hypothetical scenario, we further observed that participants anticipated that their relationship satisfaction would worsen when one of these social contacts explicitly endorsed (vs. opposed) a conspiracy theory (Studies 2, 3a, and 3b). Finally, participants expected lower relationship satisfaction with a stranger who endorsed (vs. opposed) a conspiracy theory in their online dating profile (Study 4). Importantly, across all studies we observed that participants' own conspiracy beliefs moderated the association between others' conspiracy beliefs and relationship satisfaction, revealing a similarity–dissimilarity pattern: although the association was negative among participants with weaker conspiracy beliefs, we observed signals of reversal among participants with stronger conspiracy beliefs. Our findings further suggest that a process of attitudinal distancing (among other relational changes) could explain why perceived conspiracy beliefs negatively predicted relationship satisfaction. Taken together, this research provides evidence that conspiracy beliefs have the potential to harm interpersonal relationships.
A Randomized Controlled Trial on the Timing of Soft‐Tissue Augmentation in Immediate Implant Placement: Hard‐Tissue Changes and Clinical Outcome
Authors: Cosyn Jan , Struys Thibault , Van Hove Pieter‐Jan , De Buyser Stefanie , De Bruyckere Thomas 
Published: September 2024

ABSTRACTAimTo assess the impact of the timing of soft‐tissue augmentation (STA) on mean buccal bone changes following immediate implant placement (IPP) in the anterior maxilla.Materials and MethodsPatients with a failing tooth and intact buccal bone wall in the anterior maxilla (15–25) were enrolled in this randomized controlled trial. Following single IIP and socket grafting, they were randomly allocated to the control group (immediate STA performed during the same surgical procedure) or the test group (delayed STA performed 3 months later). Implants were placed with a surgical guide and immediately restored with an implant‐supported provisional crown. Changes in bone dimensions were assessed using superimposed CBCT images taken prior to surgery and at 1‐year follow‐up. Clinical outcomes were registered at 1‐year follow‐up.ResultsTwenty patients were randomized to each group (control: 16 females, 4 males, mean age 57.6; test: 9 females, 11 males, mean age 54.2). Ten patients in the control group and 13 patients in the test group had a thick bone wall phenotype. Estimated marginal mean horizontal buccal bone loss at 1 mm below the implant shoulder was −0.553 and −0.898 mm for the control and test group, respectively. The estimated mean difference of 0.344 mm in favour of the control group was not significant (95% CI: −0.415 to 1.104; p = 0.363). Also at all other horizontal and vertical levels, no significant differences could be observed between the groups. The combination of socket grafting and STA enabled counteraction of any buccal soft‐tissue loss (≥ 0 mm) at 1 mm below the implant shoulder in 82% of the patients in the control group and in 75% of the patients in the test group (p = 1.000). The clinical outcome was favourable in both groups, yet implants in the control group demonstrated slightly less marginal bone loss (median difference 0.20 mm; 95% CI: 0.00–0.44; p = 0.028).ConclusionIn patients with an intact and mainly thick buccal bone wall in the anterior maxilla, the timing of STA following IIP had no significant impact on mean buccal bone loss.Trial RegistrationClinicalTrials.gov identifier: NCT05537545
Gottman's sound relationship house and relational resilience through infertility for couples
Authors: Brigance Clayton A. , Waalkes Phillip L. , Freedle Agata , Kim So Rin 
Published: September 2024

AbstractSome couples report that their relationship satisfaction increases through the experience of infertility. Few studies exist which explain how this phenomenon occurs through specific variables. We hypothesized that John Gottman's constructs of friendship and intimacy as well as shared meaning could explain how couples can achieve increased relationship satisfaction. We examined a regression analysis of cross‐sectional retrospective individual data for couples who are either experiencing infertility currently or have done so in the recent past. In our nonclinical sample (n = 903), mediation analyses indicated significant influencing pathways for the Gottman shared meaning system, indicating that this construct may explain how couples achieve greater emotional bonding and couple satisfaction through infertility. These findings provide couple therapists with potential areas of focus for couples navigating infertility through the lens of Gottman Method Couple Therapy, including ways to encourage deeper mutual shared meaning amidst the infertility experience.