bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intestinal adenocarcinoma in ponies: Clinical and pathological findings
Authors: Völker I. , Puschmann T. , Michutta J. , Ohnesorge B. , Wohlsein P. 
Published: March 2017

SummaryIntestinal adenocarcinomas (IACs) are rarely described in horses, particularly in ponies. Here, the clinical and pathomorphological findings of three mature ponies withIACs are reported. All animals had a history of recurrent colic, and displayed hyperfibrinogenaemia. Clinical investigations could not confirm intestinal neoplasia. On gross post‐mortem examination, papillary colonic neoplastic masses partially obliterated the intestinal lumen. In two cases, metastases were present. Histologically,IACs were classified as tubulo‐acinar subtypes with occasional stromal osseous metaplasia. In one case, prestenotic impaction had resulted in rupture of the colon with secondary septic peritonitis. In mature ponies suffering from recurrent colic intestinal neoplasia should be considered as a differential diagnosis.
Patterns of care among patients receiving sequential targeted therapies for advanced renal cell carcinoma: A retrospective chart review in the USA
Authors: Pal Sumanta K , Signorovitch James E , Li Nanxin , Zichlin Miriam L , Liu Zhimei , Ghate Sameer R , Perez Jose Ricardo , Vogelzang Nicholas J 
Published: March 2017

ObjectivesTo assess real‐world treatment patterns of targeted therapies after failure of first‐line tyrosine kinase inhibitors in patients with advanced renal cell carcinoma.MethodsA large, retrospective review of medical charts of patients with advanced renal cell carcinoma in the USA was carried out. Descriptive statistics were used to summarize physicians’ and patients’ characteristics, treatment sequences, and reasons for treatment choices. P‐values were calculated using χ2‐tests for categorical variables and Wilcoxon rank‐sum tests for continuous variables. A descriptive comparison was carried out between current results and those of a previous treatment pattern study conducted in 2012 to identify changes in treatment patterns over time.ResultsSunitinib and everolimus remained the most commonly‐used first and second targeted therapies, respectively. Among patients who continued to a third targeted therapy, everolimus and axitinib were the most commonly‐used treatments after second targeted therapy with a tyrosine kinase inhibitor and a mammalian target of rapamycin inhibitor, respectively. The use of pazopanib as first targeted therapy, and of axitinib and sorafenib as second targeted therapies, increased over time. Efficacy, treatment guidelines and a different mechanism of action were the main reasons given by physicians for choosing among second targeted therapies after failure of a first tyrosine kinase inhibitor.ConclusionsThe results of the present study document patterns of care during a period of rapid and ongoing therapeutic advancement in advanced renal cell carcinoma. Sequencing of therapies warrants ongoing analysis in light of new agents entering the advanced renal cell carcinoma treatment landscape.
Outsource planning with asymmetric supply cost information through a menu of option contracts
Authors: Nosoohi Iman , Nookabadi Ali Shahandeh 
Published: March 2017

AbstractThis paper investigates a supply contract design by a dominant manufacturer who faces a stochastic demand during a selling season. The manufacturer has several estimations of the supplier's cost with corresponding probabilities, that is, asymmetric cost information. The manufacturer designs a menu of call option contracts that include three variables: a supply order, an option, and an exercise price. We determine the optimal negative correlation between option and exercise prices as well as closed‐form formulas for the optimal supply orders. The results show that in the optimal menu of contracts either the option or the exercise price may be omitted from the menu, whereas the supply orders should always be customized for each supplier type. We show that in this problem, optimal profit assignment between contract partners under put and bidirectional option contracts is the same as call option contract studied. Numerical analysis including managerial insights is presented.
High Qm values and humidity effect on the electrical properties of (K, Na)NbO3 lead‐free piezoceramics doped with B2O3–CuO mixed oxides
Authors: Zhen Yuhua , Li Linling , Lin Yaning , Wang Ke , Zhu Fangyuan , Jia Kaili 
Published: March 2017

AbstractTo greatly enhance the mechanical quality factor (Qm) of piezoceramic materials, B2O3–CuO mixed oxides were added to a K0.48Na0.52NbO3‐based lead‐free piezoceramic (abbreviated as BC‐KNN). The results suggest that the B2O3–CuO additives effectively improved the sinterability and Qm value of the piezoceramic. An optimal Qm value as high as 2128 was obtained, which is 35 times higher than that of pure KNN ceramic. Interestingly, we found that the Qm value was sensitive to humidity of the surrounding environment. As the relative humidity (RH) increased from 25% RH to 78% RH, the Qm value of the BC‐KNN ceramics decreased from 2128 to 267. We found that the dependence of the Qm value on humidity was closely related to the instability of the relative dielectric constant (ɛr). Our results show that a dense microstructure is critical for maintaining a stable high Qm performance in a humid environment.
High Nd3+→Yb3+ energy transfer efficiency in tungsten‐tellurite glass: A promising converter for solar cells
Authors: Costa Francine Bettio , Yukimitu Keizo , Nunes Luiz Antonio de Oliveira , Figueiredo Marcio da Silva , Silva Junior Reis , Andrade Luis Humberto da Cunha , Lima Sandro Marcio , Moraes João Carlos Silos 
Published: March 2017

AbstractThis work reports on the energy transfer efficiency for Nd3+/Yb3+ co‐doped tellurite glasses (80TO2‐20WO3, in mol%,). The correlation between Yb3+ ion concentration and the downconversion mechanism was investigated using optical and thermal lens spectroscopies, which enabled investigation of the radiative and nonradiative processes, respectively, involved in energy transfer from neodymium to ytterbium. The Nd3+ near‐infrared fluorescence disappeared almost entirely when the maximum concentration of Yb3+ ions (4 mol%) was doped into the host. In contrast, there was a corresponding increase in the ytterbium emission at around 980 nm. When ytterbium was added, there was also a simultaneous reduction in the amount of heat generated by the sample due to a reduction in the nonradiative decay rate, corroborating the suspected high energy transfer efficiency of Nd3+→Yb3+. The results indicate that tungsten‐tellurite glasses may be of potential use in solar cells for matching the solar emission spectrum to the semiconductor cell.
Hepatitis C virus and its cutaneous manifestations: treatment in the direct‐acting antiviral era
Authors: Wiznia L.E. , Laird M.E. , Franks A.G. 
Published: March 2017

AbstractNew all‐oral direct‐acting antivirals (DAA) have changed the hepatitis C virus (HCV) treatment landscape. Given that dermatologists frequently encounter HCV‐infected patients, knowledge of the current treatment options and their utility in treating HCV‐associated dermatologic disorders is important. In addition to highlighting the new treatment options, we review four classically HCV‐associated dermatologic disorders – mixed cryoglobulinaemia (MC), lichen planus (LP), porphyria cutanea tarda (PCT) and necrolytic acral erythema (NAE) – and examine the role for all‐oral direct‐acting antiviral (DAA) regimens in their treatment. A literature search of English‐language publications was conducted of the PubMed and EMBASE databases using search terms including ‘hepatitis C’, ‘direct acting antivirals’, ‘cutaneous’, ‘mixed cryoglobulinemia’, ‘necrolytic acral erythema’, ‘lichen planus’, ‘porphyria cutanea tarda’, ‘rash’, as well as specific drug names, related terms and abbreviations. Currently, limited data exist on the use of DAAs in HCV‐infected patients with cutaneous side‐effects, although treatment of the underlying HCV is now recommended for nearly all patients, with the new drugs offering much‐improved dosage schedules and side‐effect profiles. The most data exist for MC, in which several studies suggest that DAAs and achievement of sustained virologic response (SVR) improve cutaneous symptoms. Studies of both older and newer regimens are limited by their small size, retrospective nature, lack of appropriate controls and wide variability in study protocols. Given the strong association, screening for HCV should be considered in patients with MC, LP, PCT and NAE.
Analysis of the German DRG data for livedoid vasculopathy and calciphylaxis
Authors: Renner R. , Dissemond J. , Goerge T. , Hoff N. , Kröger K. , Erfurt‐Berge C. 
Published: March 2017

AbstractBackgroundLivedoid vasculopathy and calciphylaxis are rare skin disorders. Large cohorts of patients have been missing so far for detailed analysis.Patients and methodsData from diagnosis‐related groups (DRGs) of hospitalized cases of livedoid vasculopathy (ntotal = 1357) and calciphylaxis (ntotal = 699) were analysed for the years 2008‐2013 concerning sex, age and frequency of diagnosis. To avoid deviations to non‐relevant secondary diagnosis and due to changes in ICD‐10 indices, we selected the two most recent available years 2013 and 2014 for evaluation of the accompanying diagnoses for both, livedoid vasculopathy (n = 519) and calciphylaxis (n = 324). Those were additionally evaluated as possible comorbidity.ResultsThe male–female ratio for livedoid vasculopathy was 2.1:1. Patients older than 45 years comprehended 74.7% of all patients with peaks between the ages of 45–50 and 70–75. Livedoid vasculopathy patients suffered from cardiovascular and renal diseases. Coding of coagulation disorders was found rarely in our analysis. For calciphylaxis, we calculated a male–female ratio of 1.7:1. Most of the patients were at an age between 65 and 80 years. Diagnosis at an age under 35 years was rare. In general, most calciphylaxis patients showed end‐stage renal disease with need of dialysis and presented with the resulting complications.ConclusionsOur data analysis shows relevant comorbidity and cofactors of these rare diseases like livedoid vasculopathy and calciphylaxis in Germany by a large number of cases.
Theorizing the Decision‐Making Process for Divorce or Reconciliation
Authors: Allen Sarah , Hawkins Alan J. 
Published: March 2017

AbstractDivorce is commonplace in the United States, with an abundant scholarship on the phenomenon. Most research has focused on predictors of divorce, associations between divorce and family member well‐being, and interventions and policies for divorcing couples and children. Although this scholarship tells us much about why couples get divorced and the impact divorce has, it has little to say about how individuals think about and couples talk about and make meaning of their decision‐making process regarding divorce or reconciliation. The purpose of this article is to examine and critique existing theoretical frameworks used to understand decision‐making processes both generally in the field and specifically in the context of divorce ideation. Our goal is to propose future research and theory directions that are better suited to capturing the complexity of decision‐making processes within the liminal space of the lives of individuals who are married but facing the proximate possibility of divorce.
The effect of rehabilitation exercises combined with direct vagina low voltage low frequency electric stimulation on pelvic nerve electrophysiology and tissue function in primiparous women: A randomised controlled trial
Authors: Yang Sumian , Sang Wenshu , Feng Jing , Zhao Haifeng , Li Xian , Li Ping , Fan Hongfang , Tang Zengjun , Gao Lina 
Published: March 2017

Aim and ObjectiveTo evaluate the effect of rehabilitation exercises combined with Direct Vagina Low Voltage Low Frequency Electric Stimulation (DES) on pelvic nerve electrophysiology and tissue function after delivery.BackgroundWhether and how DES effects pelvic floor dysfunction (PFD) are not known clearly.DesignThis was a randomised, controlled clinical trial.MethodsThe 189 primiparous women 20–35 years old and with an episiotomy or second degree episiotomy tear were divided into three groups: the control group (n = 60) received routine postpartum guidance 2 hr postpartum, the training group (n = 63) performed rehabilitation exercises (Kegel exercises and pelvic movements) from 2 days postpartum until 3 months postpartum, and the combination group (n = 66) received DES 15 times (3 times a week for 30 min at a time) beginning at the sixth week postpartum in addition to performing rehabilitation exercises. Adopt international standard scale and score method to inspect maternal life treatment, such as pelvic organ prolapse situation (POP‐Q division), the degree of incontinence score and pelvic floor muscle intensity of muscular contraction. Data were collected during the third month after delivery.ResultsThree months postpartum, there were differences among the three groups in the POP‐Q grade, the degree of incontinence score, the Oxford grade for pelvic floor muscle strength and the pelvic floor muscle electrophysiology condition. Additionally, there were significant differences regarding the pubic symphysis clearance. Rehabilitation exercises can promote healing of the maternal pubic symphysis and recovery of the pelvis. The total electrical value, type I muscle fibre strength and type II muscle fibre strength were significantly increased in the combination group after treatment than before treatment.ConclusionRehabilitation exercises combined with DES were beneficial to the recovery of postpartum pelvic nerve tissue function, and a synergistic effect was observed when the two methods were combined.Relevance to clinical practiceThese conclusions justify that rehabilitation exercise combined with DES can better relieve uncomfortable symptoms postpartum and improve the women's quality of life.
Measuring quality: caries‐related emergency department visits and follow‐up among children
Authors: Herndon Jill Boylston , Crall James J. , Carden Donna L. , Catalanotto Frank A. , Tomar Scott L. , Aravamudhan Krishna , Light Jennifer K. , Shenkman Elizabeth A. 
Published: March 2017

AbstractObjectiveThis study validated two Dental Quality Alliance system‐level measures of oral healthcare quality for children – caries‐related emergency department (ED) visits and timely follow‐up of those visits with a dentist – including formal validation of diagnosis codes used to identify caries‐related ED visits and measurement of follow‐up care.MethodsThe measures were specified for implementation with administrative claims data and validated using data from the Florida and Texas Medicaid and Children's Health Insurance Programs. Measure specification testing and measure score validation used administrative data for 7,007,765 children. We validated the diagnosis codes in claims data by comparisons with manual reviews of 300 records from a Florida hospital ED and calculation of the kappa statistic, sensitivity, and specificity.ResultsOverall agreement in caries‐related ED visit classifications between the claims data and record reviews was 87.7 percent with kappa = 0.71, sensitivity = 82 percent, and specificity = 90 percent. The calculated measure scores using administrative data found more than four‐fold variation between programs with the lowest and highest caries‐related ED visit rates (6.90/100,000 member months and 30.68/100,000 member months). The percentage of follow‐up visits within 7 days and 30 days ranged from 22‐39 percent and 34‐49 percent, respectively.ConclusionsThese National Quality Forum endorsed measures provide valid methodologies for assessing the rate of caries‐related ED visits, an important system‐level outcome indicator of outpatient prevention and disease management, and the timeliness of follow‐up with a dentist. There is significant variation in caries‐related ED visits among state Medicaid programs, and most ED visits do not have follow‐up with a dentist within 30 days.
Priming recognition in good sleepers and in insomniacs
Authors: Giganti Fiorenza , Aisa Beatrice , Arzilli Cinzia , Viggiano Maria Pia , Cerasuolo Mariangela , Conte Francesca , Ficca Gianluca 
Published: March 2017

SummaryInsomniacs often report memory and concentration problems, but these complaints have not been consistently supported by performance measurements. Furthermore, while the majority of studies have addressed explicit memory, few have investigated the implicit domain, and very little is known concerning other types of implicit memory besides procedural memory, such as priming. Thus, the purpose of the study was to investigate priming effect for visual stimuli in insomniacs and good sleepers. Twenty‐three insomniacs and 20 good sleepers performed a visual priming task in which they were asked to name new and old pictures presented at nine ascending levels of spatial filtering. Both neutral and sleep‐related stimuli were used, as previous research evidenced an attentional bias for sleep‐related stimuli. Visual priming effect was observed in both groups, suggesting that poor sleep quality does not affect this type of implicit memory. However, the identification process in insomniacs is influenced by the nature of the stimulus to identify: insomniacs recognized both new and old sleep‐related stimuli at lower spatial frequencies compared with good sleepers. The tendency to selectively attend to sleep‐related stimuli may influence top‐down processes occurring during identification of filtering stimuli, by determining a pre‐allocation of attentional resources and facilitating identification processes even when sensorial information is scant. Differences in the identification processes of sleep‐related stimuli compared with neutral ones should be carefully taken into account as possible pre‐clinical markers of insomnia in poor sleepers.
Critical conversations with children's literature: how cultural and political vignettes (CPVs) support young readers
Authors: Darvin Jacqueline 
Published: March 2017

AbstractYoung children today have greater access to culturally and politically sensitive information than at any other time in history. Although there are many positive aspects of children having greater access, negative consequences can also result, especially when they do not have sufficient structured and supportive opportunities to question, discuss and analyse the information they are receiving. Presently, teachers are faced with a multitude of intricate social phenomena in their classrooms, many of which leave them feeling apprehensive and unprepared. Some teachers of young learners need guidance, pedagogical practices and strategies to help their students address their questions and concerns about sensitive social issues in healthy, constructive ways that lead to positive, transformative action.
Emotion dysregulation and autonomic responses to film, rumination, and body awareness: Extending psychophysiological research to a naturalistic clinical setting and a chemically dependent female sample
Authors: Crowell Sheila E. , Price Cynthia J. , Puzia Megan E. , Yaptangco Mona , Cheng Sunny Chieh 
Published: March 2017

AbstractSubstance use is a complex clinical problem characterized by emotion dysregulation and daily challenges that can interfere with laboratory research. Thus, few psychophysiological studies examine autonomic and self‐report measures of emotion dysregulation with multidiagnostic, chemically dependent samples or extend this work into naturalistic settings. In this study, we used a within‐subject design to examine changes in respiratory sinus arrhythmia (RSA), electrodermal activity (EDA), and self‐reported affect across three tasks designed to elicit distinct psychophysiological and emotional response patterns. We also examined emotion dysregulation as a moderator of psychophysiological responses. Participants include 116 women with multiple comorbid mental health conditions enrolled in substance use treatment, many of whom also reported high emotion dysregulation. Participants were assessed in the treatment setting and completed three tasks: watching a sad movie clip, rumination on a stressful event, and a mindful interoceptive awareness meditation. Multilevel models were used to examine changes from resting baselines to the tasks. During the film, results indicate a significant decrease in RSA and an increase in EDA. For the rumination task, participants showed a decrease in RSA but no EDA response. For the body awareness task, there was an increase in RSA and a decrease in EDA. Emotion dysregulation was associated with differences in baseline RSA but not with EDA or with the slope of response patterns across tasks. Self‐reported affect was largely consistent with autonomic patterns. Findings add to the literature on emotion dysregulation, substance use, and the translation of psychophysiological measurements into clinical settings with complex samples.
Linking vitamin D status, executive functioning and self‐perceived mental health in adolescents through multivariate analysis: A randomized double‐blind placebo control trial
Authors: Grung Bjørn , Sandvik Asle M. , Hjelle Kay , Dahl Lisbeth , Frøyland Livar , Nygård Irene , Hansen Anita L. 
Published: March 2017

The aim of the present randomized double‐blind placebo control trial was to investigate if vitamin D supplementation had an effect on vitamin D status, executive functioning and self‐perceived mental health in a group of Norwegian adolescents during winter time. Fifty adolescents were randomly assigned into an intervention group (vitamin D pearls) or a control group (placebo pearls). Before (pre‐test in December/January) and after (post‐test in April/May) the intervention period the participants were exposed to a test procedure, consisting of blood draw, completion of cognitive tests (Tower of Hanoi and Tower of London), and the Youth Self‐report version of the Child Behavior Checklist. Multivariate data analysis showed that participants with low vitamin D status scored worse on the Tower of London tests and the more difficult sub‐tasks on the Tower of Hanoi tests. They also had a tendency to report higher frequency of externalizing behavior problems and attention deficit. At pre‐test, the overall mean vitamin D status measured as 25‐hydroxy vitamin D was 42 nmol/L, defining deficiency (Intervention group = 44 nmol/L, Control group = 39 nmol/L). However, vitamin D supplementation caused a significant increase in vitamin D status resulting in a sufficient level in the Intervention group at post‐test (mean 62 nmol/L). The results also revealed that the intervention group improved their performance on the most demanding sub‐tasks on the ToH. Overall, the study indicates that vitamin D status in adolescents may be important for both executive functioning and mental health.
Early lineages of Vespidae (Hymenoptera) in Cretaceous amber
Authors: PERRARD ADRIEN , GRIMALDI DAVID , CARPENTER JAMES M. 
Published: March 2017

AbstractThree wasp (Hymenoptera: Vespidae) fossils in Cretaceous amber (Late Albian) of northern Myanmar are described. Two are new species of the Mesozoic genusCuriosivespa(Rasnitsyn):C. zigrasisp.n.andC. striatasp.n.The third species,Protovespa haxaireigen.n. et sp.n., has a combination of features unique among Mesozoic Priorvespinae and the extant subfamilies. These well preserved fossils provide new morphological data for a cladistic analysis of the basal lineages of Vespidae. Results suggest that Euparagiinae is the sister group of all other Vespidae. The new genusProtovespaappears more closely related to extant Masarinae, Eumeninae and social wasps than to Priorvespinae. We assign it to a new subfamily: Protovespinae. Finally, fossil information combined with a phylogenetic tree shows that the main groups of Vespidae probably evolved during the Early Cretaceous.This published work has been registered in ZooBank,http://zoobank.org/urn:lsid:zoobank.org:pub:1E7E4796‐6E70‐4D81‐BB34‐0FEEA765DC25.