bluuebunny/crossref_metadata_2025_split huggingface dataset:
HISTOPATHOLOGICAL SCALE AND SYNOVITIS ALGORITHM – 15 YEARS OF EXPERIENCE: EVALUATION AND FOLLOWING PROGRESS
Authors: Krenn V. , Perino G. , Rüther W. , Krenn V. T. , Huber M. , Hügle T. , Najm А. , Müller S. , Boettner F. , Pessler F. , Waldstein W. , Kriegsmann J. , Häupl T. , Wienert S. , Krukemeyer M. G. , Sesselmann S. , Tikhilov R. M. , Morawietz L. 
Published: July 2017

The diagnostic histopathology scales are mainly the multilevel evaluation systems. The same principle is lying in the basis of synovitis scale elaboration. This scale gradually and semi-quantitatively assesses the inflammatory and immunological changes in case of synovitis considering three synovial components: thickness of synovial cellular layer, cellular stroma density and severity of inflammatory infiltration. The scale comprises four semi-quantitative grades: normal 0, mild, moderate and severe. Scale points from 0 to 9 are summated. Such sum evaluation allows to identify high and low degree synovitis. Scale points from 1 to ≤4 correspond to low degree synovitis which determines and includes the following diagnosis: arthritis associated synovitis; synovitis associated with meniscus pathology; hemochromatosis associated synovitis. Scale points from ≥5 to 9 determine high degree synovitis including diagnosis like rheumatoid arthritis; psoriatic arthritis; Lyme arthritis; post infection (reactive) arthritis and peripheral arthritis in Bekhterev’s disease. Thus, the synovitis scale allows to assess degenerative or posttraumatic (low degree synovitis) and inflammatoryrheumatoid pathology (high degree synovitis) based on histopathological diagnostics with sensitivity of 61,7% and specificity of 96,1%. The scale is characterized by a good diagnostics significance by ROC analysis (area under curve: 0,8–0,9). Two versions of synovitis scale was published: first in 2002, second reworked in 2006 and the latter includes the concept of subdivision into two groups of high and low degree synovitis. Thanking to both versions a national and international recognition of histological evaluation during 15 years was gained. To clarity diagnosis description using synovitis scale particularly in rheumatology various inflammatory antigens were suggested for immunohistochemical analysis (including Ki-67, CD68-, CD3-, CD15и CD20). This immunohistochemical scale and subdivision into low and high degree synovitis provided a possibility to assess the risk of development and biological sensitivity of rheumatoid arthritis. Thus, an important histological input was made into primary rheumatology diagnostics which did not consider tissue changes. Due to formal integration of synovitis scale into the algorithm of synovial pathology diagnostics a comprehensive classification was developed specifically for differentiated orthopaedics diagnostics.
MINIMALLY INVASIVE LUMBAR-PELVIC STABILIZATION FOR UNSTABLE PELVIC RING INJURIES
Authors: Dulaev A. K. , Kazhanov I. V. , Manukovsky V. A. , Mikityuk S. I. , Presnov R. A. , Gavrishchyuk Y. V. 
Published: July 2017

Reconstructive operations for unstable pelvic ring injuries in most cases are performed at later date after trauma (period of complete stabilization of the vital functions). The paper presents treatment outcomes of three patients with vertically unstable pelvic ring injuries where minimally invasive lumbar-pelvic fixation with pedicle screws was applied. The morphology of sacrum injury determined a configuration of the lumbar-pelvic transpedicular system. In all cases the final surgery was performed in the early period of traumatic disease, which made it possible to restore the anatomy of the pelvic ring and obtain good functional outcomes.
SYNOVIAL CYST IN THE PROJECTION OF TIBIAL TUNNEL AFTER ACL RECONSTRUCTION (CASE REPORT)
Authors: Bogatov V. B. , Sadykov R. S. , Ponamarev I. R. 
Published: July 2017

ACL tears are the most widespread lesions among isolated trauma of knee ligaments that require early surgical treatment especially in young active patients. There are various ACL reconstruction techniques where femur and tibia tunnels are formed and graft is fixed by cannulated interference screws. One of the possible complications is the formation of a postoperative soft tissue cyst in the projection of tibial tunnel. The nature as well as mechanism of cyst formation is still unclear.A relevant clinical case of cyst formation in a patient five years after ACL grating is described in this publication. MRI findings demonstrated that the origin of the cyst was hole of the tibial interference screw.Conclusion. The authors observed that synovial cyst was formed due to use of cannulated interference screws where synovial fluid was leaking from joint cavity through screw holes. Cystectomy and autografting of tibial bone tunnel allowed to reduce such complication.
SYNOVIAL FLUID D-LACTATE — BACTERIAL-SPECIFIC MARKER FOR INFECTION OF NATIVE AND PROSTHETIC JOINTS
Authors: Karbysheva S. B. , Grigoricheva L. G. , Zhyltsov I. V. , Semenov V. M. , Zolovkina A. G. , Veremei I. S. , Trampuz А. 
Published: July 2017

Infection of native and prosthetic joints remains a critical disease, associated with both significant mortality and morbidity. The diagnosis of joints infection is extremely difficult since presentation and preoperative tests are not always obvious and precise, while correct and timely diagnosis of septic etiology is crucial. In this case a rapid and accurate test would be helpful.Purpose of the study — тo evaluate the analytical performance and diagnostic capabilities of measuring the synovial fluid D-lactate for early diagnosis of infection in native and prosthetic joints.Material and methods. Test group of patients (n = 86) contained two subgroups – patients with periprosthetic infection (PPI) (n = 58) and patients with bacterial arthritis (BA) (n = 28). Control group (n = 104) also included two subgroups – patients with aseptic instability of implant components (n = 75) and patients with osteoarthritis (OA) (n = 29).Results. The authors observed that SF D-lactate ≥1,2 mmol/l was the optimal cutoff value for identifying patients with bacterial causes. The higher SF levels of D-lactate were observed in patients with BA compared to aseptic causes, (p0,0001), as well as in patients with PJI in contrast to aseptic loosening of prosthesis (p0,0001). In patients with native joints, SF D-lactate had better sensitivity (92,8%) compared to SF leucocytes (66,6%) and percentage of neutrophils (44,4%). D-lactate had better sensitivity for diagnosis of PJI (96,5%, 89,6% and 60,3% respectively). There were no significant differences in SF D-lactate levels due to different bacterial strains.Conclusion. The study demonstrated high analytical performance and diagnostic capabilities of measuring of synovial fluid D-lactate for diagnosis of BA and PJI. It is a rapid and accurate test for differentiating bacterial joint infection from the aseptic inflammatory joint diseases. This procedure can be carried out within less than one hour and be helpful in outpatient setting.
OSTEOID OSTEOMA OF THE HAMATE AS A CAUSE OF COMPRESSION NEUROPATHY OF THE ULNAR NERVE IN GUYON CANAL (CASE REPORT)
Authors: Semenkin O. M. , Izmalkov S. N. , Solopikhina E. B. , Doskovskaya E. M. , Balakleyets S. V. 
Published: July 2017

Osteoid osteoma of the wrist bones is rare and its diagnostics is complicated. A clinical case of the surgical treatment of the patient with osteoid osteoma is presented. The clinical manifestations included pain, extensors tenosynovitis and neuropathy of the ulnar nerve in guyon’s canal. The diagnosis was confirmed by computer tomography, ultrasonography and electromyography. Partial resection of the hamate including pathology area, and mobilization of the ulnar nerve in the wrist enabled authors to obtain a good functional outcome.
A Moralidade Bíblica
Authors: De Oliveira Ricardo Mendes 
Published: July 2017

Esse estudo se dedicou à origem do bem e do mal na Bíblia. Com o intuito dedesmistificar a moralidade bíblica, foram utilizadas fontes literárias e históricas que remontama esse documento. As histórias nela contida foram comparadas às histórias pagãs. Utilizou-sea Bíblia e a obra Paradise Lost de John Milton, para um paralelo entre o Deus existente nessas duas obras. O resultado foi que Deus mente e é complacente com a mentira, então a moralidade da Bíblia é mito
Crítica a la autoridad burocrática en Tras la virtud: MacIntyre contra Weber y con Weber
Authors: Serrano del Pozo Ignacio A. 
Published: July 2017

<p>Recibido: 27/04/2016 • Aceptado: 02/02/2017</p><p> </p><p><span>Tras la virtud </span>contiene una poderosa crítica a la autoridad burocrática o gerencial de base weberiana. En ella Alasdair MacIntyre ataca el carácter ficticio de los dos atributos que poseería esta forma de dominación: la eficacia organizativa y la predictibilidad de sus resultados. El objetivo de este trabajo es mostrar que la «autoridad burocrática» es la principal ideología de dominación del tiempo presente detectada por MacIntyre. Sin embargo, lejos de implicar esta postura un distanciamiento de las tesis weberianas, nuestra intención es demostrar que buena parte de los análisis que realiza el sociólogo alemán le servirán a MacIntyre para perfilar –por oposición– su idea de virtud moral, centrada en la excelencia de las prácticas y en el carácter narrativo de la vida.</p><p> </p>
New Tools for Easing System Integration, Deployment, Monitoring and Maintenance of Ocean Energy Devices
Authors: E. Omerdic  , D. Toal  , P. Finn  
Published: July 2017

This paper describes a set of novel aiding tools and technologies for system integration, deployment, monitoring and maintenance of ocean energy devices. The main component of the system is smart remotely operated vehicle ROVLATIS– a novel, multi-mode of operation marine robotics vehicle, developed at Mobile & Marine Robotics Research Centre (MMRRC), UL for operational flexibility in high-resolution near seabed survey from shallow inshore waters out to the continental shelf edge. The assistive visualisation and control tools, proposed in this paper, allow operators to have better situation awareness and enhanced vehicle control in presence of disturbances. Flexible design of these tools enables their use as separate modules, as well as their integration into unique system. Ocean energy technologies play an important part in meeting target that third of Irish electricity is generated from renewable sources by 2020. Proposed assistive tools could help developers of ocean energy devices in meeting this target during different stages of design, deployment and operation.
WIND ENERGY-GRID STABILIZATION USING A DYNAMIC FILTER COMPENSATOR
Authors: Mohamed A. El-Sayed  , Adel M. Sharaf  
Published: July 2017

Economic electric energy generation using wind energy production has been rapidly growing for the last three decades. However, the integration of a large wind scheme can pose inherent voltage instability and power quality problems. The paper presents the impact of a Novel Dynamic FACTS Compensator Scheme DFCS developed by the Second Author on voltage level stabilization and power quality enhancement of Wind-Grid connected green energy system. The Wind Energy Conversion System comprises four key parts. The wind farm, induction generator and DFCS scheme and the novel Multi loop dynamic error driven coordinated controller developed by the second Author to ensure voltage stabilization, power quality enhancement and minimal inrush transients and excursions under normal operation , wind velocity excursions and hybrid motorized-linear –nonlinear load disturbances. The integrated wind-grid scheme with four subsystems has been digitally simulated using the Matlab Simulink/Sim-Power software environment. The DFCS scheme with the coordinated dynamic error driven hybrid controller developed was fully validated. The digital simulation results have indicated that the novel new DFCS Filter Architecture and Multi loop controller did maintain voltage stabilization, enhance power quality and improve energy utilization.
Design of a PFC rectifier with fast start up response and low input current distortion
Authors: A. Amirahmadi  , A. Dastfan  , S. M. R. Rafiei  
Published: July 2017

For a PFC rectifier, normally designing of the PI compensator is based on the frequency domain model which is derived from the dynamic model of the rectifier, so it cannot guarantee a fast start up response. As the high input current quality and fast start up response are conflicting objectives and with improving one of them, another is degraded, for designing a PI controller which can provide both of them, a Multi-Objective optimization approach can be implemented. In this paper, for the first time, Strength Pareto Evolutionary Algorithm which is based on Pareto Optimality concept is used to gain a fast start up response as well as low input current distortion. In order to validate the proposed PI controller, simulation results are presented.
Cost Benefit Analysis to select clean energy solutions in dairy farm milk collection posts in Azores.
Authors: A. Rodrigues  , T. Dentinho  , C. Silva  , E. Azevedo  
Published: July 2017

The aim of this paper is to evaluate the possibility of implementation of alternative renewable energy micro-generation installations in dairy farm milk collection posts, from the technical, economical and environmental perspectives. This work was performed through a dairy farm milk collection post energy audit, to perform energy profile characterization and demand requirements. Following that, a study of the weather conditions was done and the obtained data (through CLIMAAT and MacSIMAR projects) [11] was introduced in a renewable energy solutions calculator (HOMER). Moreover, a system design from the available portfolio of micro-generation devices was defined and a cost benefit analysis of the selected alternatives was done. In the end a comparison of the current implemented solution with alternative designs was performed. Results show that from the analyzed solutions for this case, the set of PV (20Kw) and Wind (3KW) with no batteries is the best one, since it presents the least cost of energy, the smallest initial capital and the highest Net Present Cost. The sensitivity analysis derive that wind micro-turbines should be installed except if the solar radiation is on its maximum value and that in no case the use of batteries is an advantage for the system operation. For systems requiring a certain degree of energy (in this case with an average of 350 kW/day), the implementation of micro generation systems, like the ones evaluated, will never be economically viable in terms of Total Economic Value, even with generous feed-in tariff schemes. It is preferable that the grid operator makes investments in renewable energy production. To improve the system energy performance, the options should be focused on energy efficiency measures.
Sensitivity analysis for thermo-hydraulics model of a Westinghouse type PWR: verification of the simulation results
Authors: Farahani A. Z. , Yousefpour F. , Hoseyni S. M. 
Published: July 2017

Abstract
Development of a steady-state model is the first step in nuclear safety analysis. The developed model should be qualitatively analyzed first, then a sensitivity analysis is required on the number of nodes for models of different systems to ensure the reliability of the obtained results. This contribution aims to show through sensitivity analysis, the independence of modeling results to the number of nodes in a qualified MELCOR model for a Westinghouse type pressurized power plant. For this purpose, and to minimize user error, the nuclear analysis software, SNAP, is employed. Different sensitivity cases were developed by modification of the existing model and refinement of the nodes for the simulated systems including steam generators, reactor coolant system and also reactor core and its connecting flow paths. By comparing the obtained results to those of the original model no significant difference is observed which is indicative of the model independence to the finer nodes.
Helpful strategies for GPs seeing patients with medically unexplained physical symptoms: a focus group study
Authors: Aamland Aase , Fosse Anette , Ree Eline , Abildsnes Eirik , Malterud Kirsti 
Published: July 2017

BackgroundPatients with long-lasting and disabling medically unexplained physical symptoms (MUPS) are common in general practice. GPs have previously described the challenges regarding management and treatment of patients with MUPS.AimTo explore GPs’ experiences of the strategies perceived as helpful when seeing patients with MUPS.Design and settingThree focus group interviews with a purposive sample of 24 experienced GPs were held in southern Norway.MethodDiscussions were audiotaped and transcribed. Systematic text condensation was used for analysis.ResultsSeveral strategies were considered helpful during consultations with patients with MUPS. A comprehensive outline of the patient’s medical past and present could serve as the foundation of the dialogue. Reviewing the patient’s records and sharing relevant information with them or conducting a thorough clinical examination could offer ‘golden moments’ of trust and common understanding. A very concrete exchange of symptoms and diagnosis interpretation sometimes created a space for explanations and action, and confrontations could even strengthen the alliance between the GP and the patient. Bypassing conventional answers and transcending tensions by negotiating innovative explanations could help patients resolve symptoms and establish innovative understanding.ConclusionGPs use tangible, down-to-earth strategies in consultations with patients with MUPS. Important strategies were: thorough investigation of the patient’s symptoms and story; sharing of interpretations; and negotiation of different explanations. Sharing helpful strategies with colleagues in a field in which frustration and dissatisfaction are not uncommon can encourage GPs to develop sustainable responsibility and innovative solutions.
Peritoneal Dialysis in Very Low Birth Weight Neonates
Authors: Stojanović Vesna D. , Bukarica Svetlana S. , Antić Jelena B. , Doronjski Aleksandra D. 
Published: July 2017

Background The aim of this retrospective study is to evaluate clinical characteristics and outcomes of very low birth weight (VLBW) neonates with acute kidney injury (AKI) treated with peritoneal dialysis (PD). Methods This retrospective study included 10 VLBW neonates treated with PD. Intravenous (IV) cannula and umbilical venous catheter were used for the peritoneal access. Results Mean age at the moment of starting PD was 14.9 ± 9.3 days. Mean body weight (BW) was 825 ± 215 g. The average gestational age was 26.3 ± 1.1 weeks. The average duration of dialysis was 20.5 ± 14.7 h. The average ultrafiltration was 7.7 ± 4.2 mL/kg/h. At the moment of starting PD, the average BW was 302 ± 317g (22 ± 13%), higher than at birth (in patients who had PD started in first 2 weeks of their lives) or higher than the BW before AKI was diagnosed (patients who had PD started when they were older than 2 weeks). The main cause of AKI was sepsis ( n = 8/10). Dialysate leak was registered in 2 patients, 1 patient had peritonitis and the other had a blocked PD catheter. Six patients died during PD (severe sepsis), 1 died due to hypoxic encephalopathy and coma, and 2 patients survived. One patient (with hypoxic encephalopathy and coma) died 10 days after PD was stopped due to sepsis. The overall mortality was 80%. Conclusion Acute PD is still an appropriate treatment choice for VLBW neonates with AKI. In VLBW neonates, PD can be performed with an improvised PD system and catheters.
Absence of Post-Transplantation Encapsulating Peritoneal Sclerosis after Relatively Short Exposure to Peritoneal Dialysis: Prospective Analysis Using Repeated Abdominal Ct Scanning
Authors: Abrahams Alferso C. , van Gelder Maaike K. , van der Veer Jan Willem , de Jong Pim A. , van Leeuwen Maarten S. , Boer Walther H. 
Published: July 2017

Background Encapsulating peritoneal sclerosis (EPS) is the most severe complication of peritoneal dialysis (PD). Several retrospective reports published between 2007 and 2009 have suggested an increasing incidence of EPS occurring after kidney transplantation. We conducted a prospective observational study to determine the incidence of post-transplantation EPS and identify possible risk factors. Methods Consecutive PD patients undergoing kidney transplantation between 2009 and 2013 were included. Encapsulating peritoneal sclerosis was defined as gastrointestinal obstruction combined with radiological evidence of EPS. Gastrointestinal symptoms were assessed using a self-administered Gastrointestinal Symptom Rating Scale (GSRS) questionnaire. Abdominal computed tomography (CT) was performed prospectively at 6 and 18 months post-transplantation. The primary end point was EPS during follow-up. Results Fifty-three PD patients were included (age 51 ± 14 years). Mean PD duration was 31.3 months. Peritoneal dialysis solutions low in glucose degradation products and icodextrin were used by 86.8% of patients. A fast or average-fast transport status was documented in 83.0%. After a median follow-up of 19 months, complete data of 47 patients were available for analysis. None of the patients developed clinical or radiological signs of EPS. The GSRS score improved from 1.87 to 1.55 ( p = 0.024) and body weight increased from 75.9 to 78.3 kg ( p = 0.003). Only 1 patient had new onset localized (< 20%) peritoneal thickening on CT 22 months post-transplantation. Conclusion Post-transplantation EPS did not develop in this cohort of patients with a relatively short time of PD exposure. This suggests that these patients can be transplanted safely without concern for the development of EPS, at least within the follow-up period of 19 months.
Geographical distribution of Brucella melitensis inferred from rpoB gene variation
Authors: Tan Kim-Kee , Tan Yung-Chie , Chang Li-Yen , Lee Kok Wei , Nor'e Siti Sarah , Yee Wai-Yan , Hoh Chee-Choong , AbuBakar Sazaly 
Published: July 2017

Introduction: Currently available tests have limitations for the identification of Brucella species and strains, and their genetic lineage. The genome sequence of the rpoB gene encoding the β-subunit of DNA-dependent RNA polymerase was investigated for its use in genotyping Brucella melitensis.
Methodology: Complete rpoB gene sequences of globally distributed Brucella melitensis strains were analyzed. Single nucleotides polymorphisms (SNPs) of the rpoB gene sequences were identified and used to type Brucella melitensis strains.
Results: Six DNA polymorphisms were identified, of which two (nucleotides 3201 and 558) were novel. Analysis of the geographical distribution of the strains revealed a spatial clustering pattern with rpoB type 1 representing European and American strains, rpoB type 2 representing European, African, and Asian strains, rpoB type 3 representing Mediterranean strains, and rpoB type 4 representing African (C3201T) and European (C3201T/T558A) strains.
Conclusions: We report the discovery of two novel SNPs of rpoB gene that can serve as useful markers for epidemiology and geographical tracking of B. melitensis.