bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspectives and challenges in performance assessment of model predictive control
Authors: Botelho Viviane , Trierweiler Jorge Otávio , Farenzena Marcelo , Duraiski Ricardo 
Published: April 2016

AbstractThe longevity of each MPC application is strongly related to its performance maintenance. This work provides an overview of the methodologies available to fulfill this task, including a discussion about some special requirements of performance assessment methodologies for typical industrial MPC applications. The available methodologies were compared using these requirements. The best approaches were selected and compared to a new method proposed by the authors. These techniques have been applied in two case studies: the Shell benchmark process and the quadruple‐tank process. The results show that the control policy (setpoint, soft constraints, targets) followed in the MPC application should be the determining factor in selecting the methodology for performance assessment.
Performance of Cu/TiO2‐SiO2 catalysts in hydrogenation of furfural to furfuryl alcohol
Authors: Li Feng , Cao Bo , Ma Rui , Liang Jinrong , Song Hualin , Song Hua 
Published: April 2016

AbstractA series of Cu/TiO2‐SiO2 catalysts were prepared by a sol‐gel hydrothermal method and characterized by BET, SEM, TEM, XRD, XPS, and H2‐TPR. The catalysts were used for selective hydrogenation of furfural to furfuryl alcohol. Results show that based on the Cu/SiO2 catalyst, introducing a part of TiO2 into the carrier while keeping very large specific surface area would promote the reduction of CuO, inhibit the growth of Cu crystal particles, and improve the dispersity of Cu particles in the catalyst. The electronegativity of Cu is enhanced in the double‐loaded Cu/TiO2‐SiO2 catalyst, compared with single‐loaded Cu/SiO2 or Cu/TiO2 catalysts. The Cu/TiO2‐SiO2 catalyst containing 0.40 g/g (40 wt%) TiO2 in the carrier shows high furfural hydrogenation performance.
Updated results of the Gothenburg Trial of Mammographic Screening
Authors: Bjurstam Nils G. , Björneld Lena M. , Duffy Stephen W. 
Published: April 2016

BACKGROUNDThere remain uncertainties about age‐specific effects of breast cancer screening on mortality due to the disease.METHODSIn 1982, a randomized trial of mammographic screening every 18 months was started in Gothenburg, Sweden. Women between the ages of 39 and 49 years were randomized to an invitation to screening (intervention group; n = 11,792) or to usual care (the control group; n = 14,321). The corresponding numbers for women between the ages of 50 and 59 years were 10,112 and 15,997. Follow‐up data for breast cancer mortality were available up to the end of 2007. Data were analyzed by Poisson regression with conservative variance estimates.RESULTSThere were 79 breast cancer deaths in the intervention arm and 156 in the control arm, and this meant a significant 30% reduction in breast cancer mortality with the offer of screening (relative risk [RR], 0.70; 95% confidence interval [CI], 0.53‐0.93; P = .01). In women aged 39 to 49 years, there was a significant 40% reduction in breast cancer mortality (RR, 0.60; 95% CI, 0.43‐0.85; P = .003). In the 50‐ to 59‐year age group, there was a nonsignificant 18% breast cancer mortality reduction (RR, 0.82; 95% CI, 0.54‐1.26; P = .4).CONCLUSIONSThe policy of offering mammographic screening substantially reduces breast cancer mortality and can do so in women younger than 50 years. Cancer 2016;122:1832–5. © 2016 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.
Nonrandomized comparison of neurofibromatosis type 1 and non–neurofibromatosis type 1 children who received carboplatin and vincristine for progressive low‐grade glioma: A report from the Children's Oncology Group
Authors: Ater Joann L. , Xia Caihong , Mazewski Claire M. , Booth Timothy N. , Freyer David R. , Packer Roger J. , Sposto Richard , Vezina Gilbert , Pollack Ian F. 
Published: April 2016

BACKGROUNDTo evaluate tumor responses, event‐free survival (EFS), overall survival (OS), and toxicity of chemotherapy, children with neurofibromatosis type 1 (NF1) and progressive low‐grade glioma were enrolled into the Children's Oncology Group (COG) A9952 protocol and treated with carboplatin and vincristine (CV).METHODSNon‐NF1 patients were randomized to CV or thioguanine, procarbazine, 1‐(2‐chloroethyl)‐3‐cyclohexyl‐1‐nitrosourea, and vincristine in COG A9952. NF1 patients were assigned to CV only. NF1 patients and non‐NF1 patients who were treated with CV were compared with respect to baseline characteristics, toxicity, tumor responses, EFS, and OS.RESULTSA total of 127 eligible patients with NF1 were nonrandomly assigned to CV: 42 NF1 patients (33%) had events, and 6 (4.7%) died. The 5‐year EFS rate was 69% ± 4% for the CV‐NF1 group and 39% ± 4% for the CV–non‐NF1 group (P < .001). In a univariate analysis, NF1 children had a significantly higher tumor response rate and superior EFS and OS in comparison with CV‐treated children without NF1. NF1 patients and non‐NF1 patients differed significantly in amount of residual tumor, extent of resection, tumor location, and pathology. According to a multivariate analysis, NF1 was independently associated with better EFS (P < .001) but not with OS. NF1 patients also had a decreased risk of grade 3 or 4 toxicities in comparison with non‐NF1 patients. Three second malignant neoplasms occurred in NF1 patients receiving CV (CV‐NF1 group) at a median of 7.8 years (range, 7.3‐9.4 years) after enrollment, but there were none in the non‐NF1 group.CONCLUSIONSChildren with NF1 tolerated CV well and had tumor response rates and EFS that were superior to those for children without NF1. Cancer 2016;122:1928–36. © 2016 American Cancer Society.
3D time‐varying simulations of Ca2+ dynamics in arterial coupled cells: A massively parallel implementation
Authors: Zakkaroff Constantine , Moore Stephen , Dowding Stewart , David Tim 
Published: April 2016

SummaryPreferential locations of atherosclerotic plaque are strongly associated with the areas of low wall shear stress and disturbed haemodynamic characteristics such as flow detachment, flow recirculation and oscillatory flow. The areas of low wall shear stress are also associated with the reduced production of adenosine triphosphate in the endothelial layer, as well as the resulting reduced production of inositol trisphosphate (IP3). The subsequent variation in Ca2+ signalling and nitric oxide synthesis could lead to the impairment of the atheroprotective function played by nitric oxide. In previous studies, it has been suggested that the reduced IP3 and Ca2+ signalling can explain the correlation of atherosclerosis with induced low WSS and disturbed flow characteristics. The massively parallel implementation described in this article provides insight into the dynamics of coupled smooth muscle cells and endothelial cells mapped onto the surface of an idealised arterial bifurcation. We show that variations in coupling parameters, which model normal and pathological conditions, provide vastly different smooth muscle cell Ca2+ dynamics and wave propagation profiles. The extensibility of the coupled cells model and scalability of the implementation provide a solid framework for in silico investigations of the interaction between complex cellular chemistry and the macro‐scale processes determined by fluid dynamics. © 2016 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd.
Organometallic Hydrogels
Authors: Zheng Yunhui , Li Guanying , Zhang Ye 
Published: April 2016

AbstractHydrogels are soft materials with distinct three dimensional (3D) networks capturing a large water content. The similarity of hydrogels to natural tissue has made them the most promising biomaterials for use in human bodies. During the past several decades, hydrogels have attracted considerable attention from scientists in different research fields. With their contributions, the research in this field has experienced significant advances both in content and in style. Organometallic hydrogels, one special category of hydrogels in which metal ions participate in the 3D networks, have become one of the pioneering types of soft materials. Endowed with the unique properties of metal ions and coordination chemistry's structural diversity, this type of material has shown great potential for intelligent materials as part of a smart future. In this review, we focus on the state‐of‐the‐art achievements in organometallic hydrogels and provide bottom‐up insights from structure to applications.
Singularities of Solutions to Quadratic Vector Equations on the Complex Upper Half‐Plane
Authors: Ajanki Oskari , Krüger Torben , ERDŐS LÁszlÓ 
Published: April 2016

Let S be a positivity‐preserving symmetric linear operator acting on bounded functions. The nonlinear equation with a parameter z in the complex upper half‐plane ℍ has a unique solution m with values in ℍ. We show that the z‐dependence of this solution can be represented as the Stieltjes transforms of a family of probability measures v on ℝ. Under suitable conditions on S, we show that v has a real analytic density apart from finitely many algebraic singularities of degree at most 3.Our motivation comes from large random matrices. The solution m determines the density of eigenvalues of two prominent matrix ensembles: (i) matrices with centered independent entries whose variances are given by S and (ii) matrices with correlated entries with a translation‐invariant correlation structure. Our analysis shows that the limiting eigenvalue density has only square root singularities or cubic root cusps; no other singularities occur.© 2016 Wiley Periodicals, Inc.
Large Deviations for Diffusions Interacting Through Their Ranks
Authors: Dembo Amir , Shkolnikov Mykhaylo , Varadhan S. R. Srinivasa , Zeitouni Ofer 
Published: April 2016

AbstractWe prove a large deviations principle (LDP) for systems of diffusions (particles) interacting through their ranks when the number of particles tends to infinity. We show that the limiting particle density is given by the unique solution of the appropriate McKean‐Vlasov equation and that the corresponding cumulative distribution function evolves according to a nondegenerate generalized porous medium equation with convection. The large deviations rate function is provided in explicit form. This is the first instance of an LDP for interacting diffusions where the interaction occurs both through the drift and the diffusion coefficients and where the rate function can be given explicitly. In the course of the proof, we obtain new regularity results for tilted versions of such a generalized porous medium equation.© 2016 Wiley Periodicals, Inc.
Identifying long tail term from large‐scale candidate pairs for big data‐oriented patent analysis
Authors: Qu Peng , Zhang Junsheng , Yao Changqing , Zeng Wen 
Published: April 2016

SummaryPatent is a very important and valuable type of scientific and technical big data. This paper presents how to mine patent text to obtain valuable information/knowledge from large‐scale candidates obtained from these patents based on massive patent texts. We firstly propose a patent term extraction method using co‐occurrence in the abstract and first‐claim sections of patent records. There are three steps: (1) we extract candidate strings according to our definition of a term; (2) we propose an assumption to verify whether a candidate string is a qualified term or not by using the co‐occurrence of terms in the abstract and first claim; and (3) we use term frequency–inverse document frequencyAUTHOR: TF‐IDF has been defined as “term frequency–inverse document frequency”. Please check if correct. or mutual information to rank and select candidate terms. Secondly, we propose a new method to obtain valuable long tail term from patents. To fulfill the purpose, (1) we firstly build long tail term–common term pair as candidate set; (2) then we evaluate each candidate pair's value; and finally, (3) to demonstrate our method, we give an example on our result. This study provides a new perspective in extracting terms from free texts of patent records and also proposes a new method to obtain valuable long term to aid information analysis with massive patent texts. Copyright © 2016 John Wiley & Sons, Ltd.
SimMon: a toolkit for simulation of monitoring mechanisms in cloud computing environment
Authors: Zhao Xinkui , Yin Jianwei , Zhi Chen , Chen Zuoning 
Published: April 2016

SummaryMonitoring is a precondition for intelligent management in cloud computing environment, such as dynamic resource allocation. Typically, working as an auxiliary tool, a monitoring system is expected to incur the least additional resource usage, thus the strategies to improve the efficiency of monitoring mechanisms become significant. Yet the scale and monitoring requirement of different data centers vary, we cannot determine whether a monitoring mechanism would work well in a new data center before it serves the data center. To evaluate monitoring mechanisms, we propose SimMon, a toolkit for simulating monitoring mechanisms in cloud computing environments. SimMon is designed to simulate the topologies, actions, and strategies in data collection, dissemination, storage, and management processes. SimMon provides a controllable and repeatable way to evaluate monitoring mechanisms. In this paper, we describe the requirements analysis, design, implementation, and evaluation of SimMon. We simulate several different monitoring systems and compare their cost on time and resource to evaluate the efficiency of SimMon. We reproduce two usage scenarios from former literatures to demonstrate the effectiveness of SimMon on monitoring mechanisms simulation and evaluation. We build a real‐world working environment to validate the capability of SimMon on mimicking the characteristics of cloud monitoring systems. Copyright © 2016 John Wiley & Sons, Ltd.
Parallel multi‐core hyper‐heuristic GRASP to solve permutation flow‐shop problem
Authors: Alekseeva Ekaterina , Mezmaz Mohand , Tuyttens Daniel , Melab Nouredine 
Published: April 2016

SummaryIn this paper, we aim to propose a parallel multi‐core hyper‐heuristic based on greedy randomized adaptive search procedure (GRASP) for the permutation flow‐shop problem with the makespan criterion. The GRASP is a well‐known two‐phase metaheuristic. First, a construction phase builds a complete solution iteratively, component by component, by a greedy randomized algorithm. After that, a local search phase improves this solution. The choice of a component and the order in which it is added in a solution mostly depend on its incremental cost. Thus, a basic GRASP configuration is defined by a cost function, a probabilistic parameter of greediness and a neighbourhood structure. We consider five cost functions and seven well‐known neighbourhood structures. In this paper a cost function based on a bounding operator is integrated in GRASP for the first time. Mechanisms that investigate automatically algorithm configurations refer to hyper‐heuristics. Our hyper‐heuristic investigates 315 GRASP configurations and reports which one produces better results. Parallel multi‐core computing is used as a way to efficiently implement the hyper‐heuristic. Taillard's benchmark instances are used to test the hyper‐heuristic for the permutation flow‐shop problem. Copyright © 2016 John Wiley & Sons, Ltd.
A Set of Efficient nD NMR Protocols for Resonance Assignments of Intrinsically Disordered Proteins
Authors: Wiedemann Christoph , Bellstedt Peter , Häfner Sabine , Herbst Christian , Bordusa Frank , Görlach Matthias , Ohlenschläger Oliver , Ramachandran Ramadurai 
Published: April 2016

AbstractThe RF pulse scheme RN[N‐CA HEHAHA]NH, which provides a convenient approach to the acquisition of different multidimensional chemical shift correlation NMR spectra leading to backbone resonance assignments, including those of the proline residues of intrinsically disordered proteins (IDPs), is experimentally demonstrated. Depending on the type of correlation data required, the method involves the generation of in‐phase (15N)x magnetisation via different magnetisation transfer pathways such as H→N→CO→N, HA→CA→CO→N, H→N→CA→N and H→CA→N, the subsequent application of 15N‐13Cα heteronuclear Hartmann‐Hahn mixing over a period of ≈100 ms, chemical‐shift labelling of relevant nuclei before and after the heteronuclear mixing step and amide proton detection in the acquisition dimension. It makes use of the favourable relaxation properties of IDPs and the presence of 1JCαN and 2JCαN couplings to achieve efficient correlation of the backbone resonances of each amino acid residue “i” with the backbone amide resonances of residues “i−1” and “i+1”. It can be implemented in a straightforward way through simple modifications of the RF pulse schemes commonly employed in protein NMR studies. The efficacy of the approach is demonstrated using a uniformly (15N,13C) labelled sample of α‐synuclein. The different possibilities for obtaining the amino‐acid‐type information, simultaneously with the connectivity data between the backbone resonances of sequentially neighbouring residues, have also been outlined.
Reverse Anomeric Effect in Large‐Amplitude Pyridinium Amide‐Containing Mannosyl [2]Rotaxane Molecular Shuttles
Authors: Riss‐Yaw Benjamin , Waelès Philip , Coutrot Frédéric 
Published: April 2016

AbstractThe reverse anomeric effect (RAE) was investigated in different mannosyl [2]rotaxane molecular shuttle isomers that contain dibenzo‐24‐crown‐8 (DB24C8) as the macrocycle, and anilinium and pyridinium amide as molecular stations. The switching on or off of the RAE was possible depending on both the pyridinium amide motif and the localization of the DB24C8 along the thread. The 1C4 mannopyranosyl chair‐like conformation was observed in all the non‐interlocked molecules because the anomeric carbon of the mannose is linked to the positively charged nitrogen of the pyridinium unit. In the protonated rotaxanes, the 1C4 chair conformation of the mannose end remains because the DB24C8 resides around the best anilinium station, which is located at the other end of the axle. Upon deprotonation of the anilinium, the DB24C8 shuttles with a large‐amplitude motion toward the pyridinium amide stations, where it interacts in a different fashion depending on the pyridinium motif. In one molecular shuttle, the RAE could be switched on or off with control at one end of the encircled thread upon protonation/deprotonation of the other end, through shuttling of the DB24C8.
Therapeutic Alliance in Internet‐Delivered Cognitive Behaviour Therapy for Depression or Generalized Anxiety
Authors: Hadjistavropoulos Heather D. , Pugh Nicole E. , Hesser Hugo , Andersson Gerhard 
Published: April 2016

There has been limited research on therapeutic alliance in the context of therapist‐assisted Internet‐delivered cognitive behaviour therapy (ICBT) when delivered in clinical practice. The present study investigated therapeutic alliance in ICBT delivered to patients seeking treatment for symptoms of depression (n = 83) or generalized anxiety (n = 112) as part of an open dissemination trial. ICBT was provided by 27 registered therapists or 28 graduate students working in six geographically dispersed clinics; therapist‐assistance was delivered primarily through secure messages and occasionally telephone calls. The Generalized Anxiety Disorder‐7 and Patient Health Questionnaire‐9 were collected pre‐, mid‐ and post‐treatment, and the Therapeutic Alliance Questionnaire was assessed mid‐ and post‐treatment. Therapeutic alliance ratings were high both at mid‐treatment and post‐treatment (above 80%). There was no relationship between therapeutic alliance ratings and improvement on primary outcomes. Among patients treated for depression, lower ratings of mid‐treatment alliance were associated with concurrent treatment by a psychiatrist and fewer phone calls and emails from their therapist. Among patients treated for generalized anxiety, ratings of mid‐treatment alliance were higher among registered providers as compared to graduate students. Multiple directions for future research on therapeutic alliance in ICBT are offered, including suggestions for developing a new measure of therapeutic alliance specific to ICBT and measuring therapeutic alliance throughout the treatment process. Copyright © 2016 John Wiley & Sons, Ltd.Key Practitioner Message

This research demonstrated that therapeutic alliance ratings were very strong at both mid‐ and post‐treatment among patients who received Internet‐delivered cognitive behaviour therapy (ICBT) for depression or anxiety in clinical practice.
Among patients receiving ICBT for depression, lower ratings of therapeutic alliance were associated with patients reporting concurrent treatment by a psychiatrist and with the receipt of fewer phone calls and emails from the therapist.
Among patients receiving ICBT for generalized anxiety, ratings of alliance were higher when patients were treated by registered providers as compared to graduate students.
Therapeutic alliance ratings did not predict outcome in ICBT for depression or anxiety.
Practitioners have reason to be confident that a therapeutic relationship can be formed in ICBT when delivered in clinical practice.
New Insights into CO2 Absorption Mechanisms with Amino‐Acid Ionic Liquids
Authors: Yang Qiwei , Wang Zhiping , Bao Zongbi , Zhang Zhiguo , Yang Yiwen , Ren Qilong , Xing Huabin , Dai Sheng 
Published: April 2016

AbstractThe last decade saw an explosion of interest in using amine‐functionalized materials for CO2 capture and conversion, and it is of great importance to elucidate the relationship between the molecular structure of amine‐functionalized materials and their CO2 capacity. In this work, based on a new quantitative analysis method for the CO2 absorption mechanism of amino‐acid ionic liquids (ILs) and quantum chemical calculations, we show that the small difference in the local structure of amine groups in ILs could lead to much different CO2 absorption mechanisms, which provides an opportunity for achieving higher CO2 capacity by structure design. This work revealed that the actual CO2 absorption mechanism by amino‐acid ILs goes beyond the apparent CO2/amine stoichiometry; a rigid ring structure around the amine group in ILs creates a unique electrostatic environment that inhibits the deprotonation of carbamic acid and enables actually equimolar CO2/amine absorption.
Nanostructurally Controlled Hydrogel Based on Small‐Diameter Native Chitin Nanofibers: Preparation, Structure, and Properties
Authors: Mushi Ngesa Ezekiel , Kochumalayil Joby , Cervin Nicholas Tchang , Zhou Qi , Berglund Lars A. 
Published: April 2016

AbstractChitin nanofibers of unique structure and properties can be obtained from crustacean and fishery waste. These chitin nanofibers have roughly 4 nm diameters, aspect ratios between 25–250, a high degree of acetylation and preserved crystallinity, and can be potentially applied in hydrogels. Hydrogels with a chitin nanofiber content of 0.4, 0.6, 0.8, 1.0, 2.0, and 3.0 wt % were successfully prepared. The methodology for preparation is new, environmentally friendly, and simple as gelation is induced by neutralization of the charged colloidal mixture, inducing precipitation and secondary bond interaction between nanofibers. Pore structure and pore size distributions of corresponding aerogels are characterized using auto‐porosimetry, revealing a substantial fraction of nanoscale pores. To the best of our knowledge, the values for storage (13 kPa at 3 wt %) and compression modulus (309 kPa at 2 wt %) are the highest reported for chitin nanofibers hydrogels.