bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of skeletal muscle contractile duration throughout the whole day: reducing sedentary time and promoting universal physical activity in all people
Authors: Hamilton Marc T. 
Published: June 2017

AbstractA shared goal of many researchers has been to discover how to improve health and prevent disease, through safely replacing a large amount of daily sedentary time with physical activity in everyone, regardless of age and current health status. This involves contrasting how different muscle contractile activity patterns regulate the underlying molecular and physiological responses impacting health‐related processes. It also requires an equal attention to behavioural feasibility studies in extremely unfit and sedentary people. A sound scientific principle is that the body is constantly sensing and responding to changes in skeletal muscle metabolism induced by contractile activity. Because of that, the rapid time course of health‐related responses to physical inactivity/activity patterns are caused in large part directly because of the variable amounts of muscle inactivity/activity throughout the day. However, traditional modes and doses of exercise fall far short of replacing most of the sedentary time in the modern lifestyle, because both the weekly frequency and the weekly duration of exercise time are an order of magnitude less than those for people sitting inactive. This can explain why high amounts of sedentary time produce distinct metabolic and cardiovascular responses through inactivity physiology that are not sufficiently prevented by low doses of exercise. For these reasons, we hypothesize that maintaining a high metabolic rate over the majority of the day, through safe and sustainable types of muscular activity, will be the optimal way to create a healthy active lifestyle over the whole lifespan.
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Diffusion MRI Phenotypes Predict Overall Survival Benefit from Anti-VEGF Monotherapy in Recurrent Glioblastoma: Converging Evidence from Phase II Trials
Authors: Ellingson Benjamin M. , Gerstner Elizabeth R. , Smits Marion , Huang Raymond Y. , Colen Rivka , Abrey Lauren E. , Aftab Dana T. , Schwab Gisela M. , Hessel Colin , Harris Robert J. , Chakhoyan Ararat , Gahrmann Renske , Pope Whitney B. , Leu Kevin , Raymond Catalina , Woodworth Davis C. , de Groot John , Wen Patrick Y. , Batchelor Tracy T. , van den Bent Martin J. , Cloughesy Timothy F. 
Published: June 2017

Abstract
Purpose: Anti-VEGF therapies remain controversial in the treatment of recurrent glioblastoma (GBM). In the current study, we demonstrate that recurrent GBM patients with a specific diffusion MR imaging signature have an overall survival (OS) advantage when treated with cediranib, bevacizumab, cabozantinib, or aflibercept monotherapy at first or second recurrence. These findings were validated using a separate trial comparing bevacizumab with lomustine.
Experimental Design: Patients with recurrent GBM and diffusion MRI from the monotherapy arms of 5 separate phase II clinical trials were included: (i) cediranib (NCT00035656); (ii) bevacizumab (BRAIN Trial, AVF3708g; NCT00345163); (iii) cabozantinib (XL184-201; NCT00704288); (iv) aflibercept (VEGF Trap; NCT00369590); and (v) bevacizumab or lomustine (BELOB; NTR1929). Apparent diffusion coefficient (ADC) histogram analysis was performed prior to therapy to estimate “ADCL,” the mean of the lower ADC distribution. Pretreatment ADCL, enhancing volume, and clinical variables were tested as independent prognostic factors for OS.
Results: The coefficient of variance (COV) in double baseline ADCL measurements was 2.5% and did not significantly differ (P = 0.4537). An ADCL threshold of 1.24 μm2/ms produced the largest OS differences between patients (HR ∼ 0.5), and patients with an ADCL &gt; 1.24 μm2/ms had close to double the OS in all anti-VEGF therapeutic scenarios tested. Training and validation data confirmed that baseline ADCL was an independent predictive biomarker for OS in anti-VEGF therapies, but not in lomustine, after accounting for age and baseline enhancing tumor volume.
Conclusions: Pretreatment diffusion MRI is a predictive imaging biomarker for OS in patients with recurrent GBM treated with anti-VEGF monotherapy at first or second relapse. Clin Cancer Res; 23(19); 5745–56. ©2017 AACR.
BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity
Authors: Emery Caroline M. , Monaco Kelli-Ann , Wang Ping , Balak Marissa , Freeman Alyson , Meltzer Jodi , Delach Scott M. , Rakiec Daniel , Ruddy David A. , Korn Joshua M. , Haling Jacob , Acker Michael G. , Caponigro Giordano 
Published: June 2017

Abstract
Alterations in MEK1/2 occur in cancers, both in the treatment-naïve state and following targeted therapies, most notably BRAF and MEK inhibitors in BRAF-V600E–mutant melanoma and colorectal cancer. Efforts were undertaken to understand the effects of these mutations, based upon protein structural location, and MEK1/2 activity. Two categories of MEK1/2 alterations were evaluated, those associated with either the allosteric pocket or helix-A. Clinically, MEK1/2 alterations of the allosteric pocket are rare and we demonstrate that they confer resistance to MEK inhibitors, while retaining sensitivity to BRAF inhibition. Most mutations described in patients fall within, or are associated with, helix-A. Mutations in this region reduce sensitivity to both BRAF and MEK inhibition and display elevated phospho-ERK1/2 levels, independent from increases in phospho-MEK1/2. Biochemical experiments with a representative helix-A variant, MEK1-Q56P, reveal both increased catalytic efficiency of the activated enzyme, and phosphorylation-independent activity relative to wild-type MEK1. Consistent with these findings, MEK1/2 alterations in helix A retain sensitivity to downstream antagonism via pharmacologic inhibition of ERK1/2. This work highlights the importance of classifying mutations based on structural and phenotypic consequences, both in terms of pathway signaling output and response to pharmacologic inhibition.
Implications: This study suggests that alternate modes of target inhibition, such as ERK inhibition, will be required to effectively treat tumors harboring these MEK1/2-resistant alleles. Mol Cancer Res; 15(10); 1431–44. ©2017 AACR.
Geographic Variation in the Use of Oral Anticoagulation Therapy in Stroke Prevention in Atrial Fibrillation
Authors: Hernandez Inmaculada , Saba Samir , Zhang Yuting 
Published: June 2017

Background and Purpose—
Underuse of oral anticoagulation in stroke prevention in atrial fibrillation is common; however, it remains unknown how it varies geographically. The objective of this study was to evaluate geographic variation in oral anticoagulation use and in the initiation of new oral anticoagulants (NOACs).

Methods—
Using 2013 to 2014 claims data from a 5% random sample of Medicare beneficiaries, we identified patients newly diagnosed with atrial fibrillation who initiated NOACs (n=8659), warfarin (n=11 771) or no oral anticoagulation therapy (n=18 226) in 2013 to 2014. Each patient was assigned to 1 of the 306 Dartmouth hospital-referral regions based on his/her zip code. We constructed logistic regressions to calculate the mean adjusted probability of initiating oral anticoagulation and the mean adjusted probability of initiating an NOAC among patients on oral anticoagulation in each hospital-referral region, after adjustment for demographic, clinical, and provider characteristics and type of insurance. Finally, we computed the correlation between 2 probabilities.

Results—

Higher in the Midwest (0.54) and Northeast (0.54) and lowest in the South (0.47), the mean adjusted probability of initiating oral anticoagulation was 0.51, ranging from 0.32 to 0.72. The mean adjusted probability of being prescribed an NOAC among those on oral anticoagulation was 0.42 and was highest in the South (0.50) and lowest in the Midwest (0.36) and Northeast (0.39). In areas with the lower use of oral anticoagulation, patients on any oral anticoagulation therapy had a higher likelihood of being prescribed an NOAC (correlation coefficient, −0.16;
P
=0.006).

Conclusions—
Large geographic variation exists in oral anticoagulation use in atrial fibrillation. The use of oral anticoagulation is lower in the South, where the rates of stroke are unusually high. In the future, it will be important to analyze whether the high rates of stroke in the South can be partially attributed to the underuse of oral anticoagulation in this region.
Improved Consistency of Climate Projections over Europe after Accounting for Atmospheric Circulation Variability
Authors: Saffioti Claudio , Fischer Erich M. , Knutti Reto 
Published: June 2017

Abstract
The influence of atmospheric circulation on winter temperature and precipitation trends over Europe in the period 2006–50 is investigated in a 21-member initial condition ensemble from a fully coupled global climate model and in a multimodel framework consisting of 40 different models. Five versions of a dynamical adjustment method based on empirical orthogonal function analysis of sea level pressure are introduced, and their performance in removing the effect of atmospheric circulation on temperature and precipitation is tested. The differences in atmospheric circulation as simulated by different models in their control runs and under the historical and representative concentration pathway 8.5 (RCP8.5) forcing scenarios are investigated. Dynamical adjustment is applied to the multimodel ensemble to demonstrate that a substantial fraction of the uncertainty in projected European temperature and precipitation trends is explained by atmospheric circulation variability. A statistically significant response of sea level pressure to anthropogenic forcing is identified in the multimodel ensemble under the RCP8.5 scenario. This forced response in atmospheric circulation is associated with a dynamical contribution to the long-term multimodel mean temperature and precipitation trends. The results highlight the importance of accounting for the impact of atmospheric circulation variability on trends in regional climate projections.
Tutorial on rotational seismology and its applications in exploration geophysics
Authors: Li Zhenhua , van der Baan Mirko 
Published: June 2017

Traditionally, seismological interpretations are based on the measurement of only translational motions, such as particle displacement, velocity, and/or acceleration, possibly combined with pressure changes; yet theory indicates that rotational motions should also be observed for a complete description of all ground motions. The recent and ongoing development of rotational sensors renders a full analysis of the translational and rotational ground motion possible. We have developed the basic mathematical theory related to rotational motion. And we also evaluated several instruments used to directly measure the rotational ground motion, which may be applicable for exploration geophysics. Finally, we made several applications of rotational motion in exploration geophysics, namely, (1) P- and S-wavefield separation, (2) wavefield reconstruction, (3) ground-roll removal, (4) microseismic event localization and reflection seismic migration by wavefield extrapolation, and (5) moment tensor inversion. The cited research shows that in particular, the information on the spatial gradient of the wavefield obtained by rotational sensors is beneficial for many purposes. This tutorial is meant to (1) enhance familiarity with the concept of rotational seismology, (2) lead to additional applications, and (3) fast track the continued development of rotational sensors for global and exploration geophysical use.
Formation of Doubly Nitrosyl-Bridged Diruthenium Complex Bearing Tridentate Ethylbis(2-pyridylethyl)amine via Conversion of Nitrate
Authors: Suzuki Tomoyo , Hemmi Shohei , Kazama Yuka , Oyama Dai , Nagao Hirotaka 
Published: June 2017

Abstract
A doubly nitrosyl-bridged dinuclear ruthenium complex, {Ru2(µ-NO)2}, bearing tridentate ethylbis(2-pyridylethyl)amine (ebpea) and acetonitrile as supporting and co-existing ligands, respectively, [{Ru(µ-NO)(ebpea)(NCMe)}2]2+ ([1]2+) has been synthesized by a reaction of tris(acetonitrile)ruthenium(II) complex with sodium nitrate in ethanol. The ebpea ligand coordinated with two pyridyl- and one amine-nitrogen atoms in a meridional mode. The dinuclear ruthenium complex containing two nitrosyl ligands bridging between two ruthenium centers as a bending mode, showed two stepwise one-electron oxidation waves at 0.03 and 0.57 V vs. Ag|0.01 M AgNO3 in MeCN and a strong characteristic NO stretching vibrational mode ν(NO) at 1336 cm−1, indicating the electronic structure of the {RuNO}-moieties was an octahedral {RuNO}8-type. The dinuclear ruthenium complex reacted with acid to give mononuclear ruthenium complexes with evolution of dinitrogen oxide.
Sustainable operations management and benchmarking in brewing: A factor weighting approach
Authors: Bumblauskas Daniel P. 
Published: June 2017

The brewing industry has been moving towards more efficient use of energy, water reuse and stewardship, and the tracking of greenhouse gas (GHG) emissions to better manage environmental and social responsibility. Commercial breweries use a great deal of water and energy to convert one gallon (liter) of water into one gallon (liter) of beer. An analysis was conducted on sustainable operations and supply chain management at various United States and international breweries, specifically Europe, to benchmark brewery performance and establish common metrics for sustainability in the beer supply chain. The primary research questions explored in this article are whether water reclamation and GHG emissions can be properly monitored and measured and if processes can be created to help control waste (lean) and emissions. Additional questions include how we can use operations management strategies and techniques such as the Factor-Weighted Method (FWM) in industries such as brewing to develop sustainability scorecards.
PROSPECTS FOR THE DEVELOPMENT OF THE SINGLE-WINDOW SYSTEM IN THE SPHERE OF FOREIGN TRADE IN THE KYRGYZ REPUBLIC
Authors: Абдынасыров Уран , Abdynasyrov Uran 
Published: June 2017

The article considers issues of the prospective development
of the «single window system» in the foreign arena of the Kyrgyz
Republic. The main directions and methods to improve the
system and tentative implementation results are considered. The
successful implementation of this system will expand the scope of
foreign trade of the Kyrgyz Republic, which is the current task of
an adaptation in the Eurasian Economic Union, as well as interaction
with the «Silk Road Economic Belt» project.
MANAGEMENT PROBLEMS OF INVESTMENTCONSTRUCTION COMPLEX DEVELOPMENT IN VOLGOGRAD REGION
Authors: Чернецкова Анна , Cherneckova Anna , Борисова Наталья , Borisova Natal'ya , Борисов Алексей , Borisov Alexey 
Published: June 2017

This article discusses the development of the management
problems of investment-building complex in the Volgograd
region. The state of investment-building complex in the region is
analyzed, a comparison with the general trend of development of
investment and construction of the complex in Russia is provided.
To solve the problem area of advanced development in the territory
of the Volgograd region is proposed, and options for building clusters
in the Volgograd agglomeration area are discussed.
Performance of Loaded Thermal Storage Unit with a Commercial Phase Change Materials based on Energy and Exergy Analysis
Authors: Olimat Abdullah Nasrallh , Awad Ahmad S , Abo shaban Nabil 
Published: June 2017

This work presents an energy/exergy analysis to investige performance of thermal storage unit which loaded with a commercial phase change material (Plus ICE H190). The influence of fluid parameters on the energy/exergy effectiveness was examined. The temporal changes of the energy and exergy rate and performace of the storage unit are obtained in the results. Latent heat principle is considered an efficient method to gain a higher effectiveness of system from an energy and exergy aspects. The fluid mass flow rate during charging and discharging periods were 2.50 kg/min and 1.26 kg/min, respectively. The results showed a significant increase of thermal resistance on the thermal storage unit performance. Fluid and phase change material show significant temperature difference on the rate of energy/exergy quantites and the time of melting or soldification. Ther results indicated that the average rate of energy and exergy were 1.3 kW and 0.54 kW, respectively. Wheras, energy and exergy average rate during discarging periods were 1.1 kW and 0.31 kW, respectively. Also, the global rate during the experimetal periods were about 84% and 54%, respectively.
Genome-Wide Associations for Water-Soluble Carbohydrate Concentration and Relative Maturity in Wheat Using SNP and DArT Marker Arrays
Authors: Ovenden Ben , Milgate Andrew , Wade Len J , Rebetzke Greg J , Holland James B 
Published: June 2017

AbstractImproving water-use efficiency by incorporating drought avoidance traits into new wheat varieties is an important objective for wheat breeding in water-limited environments. This study uses genome wide association studies (GWAS) to identify candidate loci for water-soluble carbohydrate accumulation—an important drought-avoidance characteristic in wheat. Phenotypes from a multi-environment trial with experiments differing in water availability and separate single nucleotide polymorphism (SNP) and diversity arrays technology (DArT) marker sets were used to perform the analyses. Significant associations for water-soluble carbohydrate accumulation were identified on chromosomes 1A, 1B, 1D, 2D, and 4A. Notably, these loci did not collocate with the major loci identified for relative maturity. Loci on chromosome 1D collocated with markers previously associated with the high molecular weight glutenin Glu-D1 locus. Genetic × environmental interactions impacted the results strongly, with significant associations for carbohydrate accumulation identified only in the water-deficit experiments. The markers associated with carbohydrate accumulation may be useful for marker-assisted selection of drought tolerance in wheat.
Determinants of placenta previa: a case-control study
Authors: Shobeiri Fatemeh , Jenabi Ensiyeh , Karami Manoochehr , Karimi Simin 
Published: June 2017

Background: The risk factors of placenta previa differ around the world. This study evaluated risk factors of pregnancies complicated with placenta previa during a 5-year period in a referral center in Hamadan, Iran.
Methods: This case control study was conducted in Hamadan city (Hamadan Province of Iran) from April 2013 to March 2017. The cases were women whose deliveries were complicated by placenta previa and the controls were those who delivered without placenta previa. We recruited 130 cases and 130 controls. Multivariate unconditional logistic regression analysis was conducted, and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
Results: The OR of placenta previa was 4.08 (95% CI= 1.44, 11.58) by maternal age, 4.08 (95% CI =1.44, 11.58) by preterm labor, and 6.64 (95% CI =1.09, 40.45) by prior operations of the uterine cavity, compared to normal deliveries and after adjusting for other variables. Multiparity, prior spontaneous abortions, and prior cesarean sections were not statistically significant risk factors for placenta previa, when adjusted for other variables.
Conclusion: Our study suggests that high maternal age and prior operations of the uterine cavity are risk factors for placenta previa.
35 años del Seminario de Biotecnología en la Universidad Nacional de Colombia y 30 años del IBUN
Authors: Montoya Castaño Dolly 
Published: June 2017

Este año celebramos treinta y cinco años de trabajo de una comunidad interdisciplinaria empeñada desde 1982 en impulsar el desarrollo de la biotecnología en Colombia, que exigía un espacio académico articulador de disciplinas de ciencias básicas y de las ingenierías. Esta comunidad se propuso crear el Instituto de Biotecnología en la Universidad Nacional de Colombia (IBUN) y después de cinco años de trabajo continuo logró hace 30 años, en 1987, su creación. El fortalecimiento del IBUN ha estado íntimamente ligado a la cualificación y al crecimiento de nuestra comunidad universitaria, conformada por investigadores (senior y junior), estudiantes de todos los niveles de formación y funcionarios administrativos.
О формировании познавательного интереса в процессе обучения
Authors: Шонин Максим Юрьевич 
Published: June 2017

<p class="MsoNormal" style="margin-top: 0cm; margin-right: 9.2pt; margin-bottom: 10.0pt; margin-left: -1.0cm; text-align: justify; text-indent: 35.45pt; line-height: normal;"><span style="font-size: 14.0pt; font-family: 'Times New Roman'; background: white;">В данной статье раскрываются понятия «интерес» и <span style="mso-spacerun: yes;"> </span>«познавательный интерес», показана их взаимосвязь через «инициативность». Описаны<span style="mso-spacerun: yes;"> </span>условия, направленные на развитие познавательного интереса, а также рассматриваются его уровни. В заключении был проведен эксперимент, направленный на определение уровня познавательного интереса по «методики конвертов».</span></p>
Экоустойчивость человека и динамичность цифрового мира
Authors: Ярославцева Елена Ивановна 
Published: June 2017

<p>Фундаментальные проблемы современной философии, ставшей более творческой, свободной в поиске, создают возможность нахождения решений для новых, весьма сложных задач общества XXI века. Особенно важно то, что философский дискурс сочетается с технологическим мышлением, позволяющим не просто увидеть целостный мир, но и понимать, как он будет существовать, впитывая в себя современный Hi-tech, насыщаясь постоянными технологическими новшествами, создаваемыми человеком. Возникающая динамичная устойчивость человека фактически определяет контуры будущего. И важно создать устройство мира, собственно культуру и социальную среду, которые могли бы в перспективе эффективно использовать творческую энергию развивающегося индивида.</p>
MORTALIDADE POR QUEDAS DE LEITOS HOSPITALARES: ESTUDO RETROSPECTIVO
Authors: Bausch Amanda Bierhals , Waterkemper Roberta , Linch Graciele Fernanda da Costa , Paz Adriana Aparecida , Pelegrini Alísia Helena Weis 
Published: June 2017

<p>Objetivo: Identificar a prevalência e caracterizar os óbitos por quedas de leito hospitalar em Porto Alegre, no Rio Grande do Sul e no Brasil. Método: Estudo retrospectivo, com dados do Departamento de Informática do Sistema Único de Saúde (DATASUS), realizado em 2015. Utilizou-se a classificação CID-10: W06 Queda de um leito. Calculou-se frequência relativa, razão de sexos e taxas de letalidade. Resultados: Na distribuição por faixa etária verifica-se maior número de óbitos a partir dos 60 anos. O sexo feminino predomina no número total de óbitos, mas até os 70 anos morreram mais homens. Os coeficientes de letalidade aumentaram progressivamente nas três esferas governamentais. Conclusão: Considerando os coeficientes de letalidade houve aumento nos valores. Maior número de óbitos em idosos do sexo feminino. Verifica-se que a promoção de segurança do paciente e prevenção de quedas são um desafio e a enfermagem emerge como fundamental nesse processo.</p><p> </p><p><strong>Descritores:</strong> Sistemas de informação em saúde; Acidentes por quedas; Enfermagem.<strong> </strong></p>
Congratulations! The Best Paper Award 2014
Authors: Office Editorial 
Published: June 2017

The fifth Best Paper Award 2014 ceremony was held in Kasumigaseki, Tokyo, Japan, on August 1, 2014, attended by the winner and IJAT committee members who took part in the selection process. The Best Paper was severely selected from among 84 papers published in Vol.7 (2013). The Best Paper Award winner was given a certificate with a nearly US$1,000 honorarium.
We congratulate the winner and sincerely wish for his future success.

Title: Positioning Characteristics of a MEMS Linear Motor Utilizing a Thin Film Permanent Magnet and DLC Coating
Authors: Ryogen Fujiwara, Tadahiko Shinshi, and Minoru Uehara
Int. J. of Automation Technology Vol.7 No.2, March, 2013