bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Evaluation of Silorane and Nano-hybrid Resin Composite Restorations in Class II Cavities up to 3 Years
Authors: Öztürk-Bozkurt F , Toz T , Kara-Tuncer A , Gözükara-Bağ H , Özcan M 
Published: September 2016

SUMMARY
In this study, the clinical performance of a silorane-based resin composite (SC) vs a nano-hybrid resin composite (NHC) was evaluated in Class II cavities. From January 2012 to February 2013, a total of 29 patients (eight men, 21 women; mean age, 24 ± 5 years) received 29 pairs of restorations using both SC (Filtek Silorane, 3M ESPE) and NHC (Filtek Z550, 3M ESPE) materials. Patients were followed until February 2015. One operator performed all restorations using the corresponding adhesive resins according to the manufacturers' instructions. Two calibrated independent examiners evaluated the restorations at one week, six months, and then annually using the modified United States Public Health Service (USPHS) criteria for anatomic form, marginal adaptation, color match, surface roughness, marginal discoloration, secondary caries, and postoperative sensitivity. Changes in the USPHS parameters were analyzed with the McNemar test (α=0.05). The mean observation period was 31.2 months. Marginal adaptation was the only parameter that showed a significant difference and was worse for SC than NHC (p=0.012). At the final recall, 17 restorations from the SC group and five from the NHC group received a score of 1 (explorer catches). These scores were significantly different between baseline and final recall for SC (p&lt;0.001) but not for NHC (p&gt;0.05). Both NHC and SC performed similarly in Class II restorations up to three years except for marginal adaptation, for which the latter demonstrated significant deterioration at the final recall compared with baseline.
Management of Amelogenesis Imperfecta: A 15-Year Case History of Two Siblings
Authors: Dursun E , Savard E , Vargas C , Loison-Robert L , Cherifi H , Bdeoui F , Landru M-M 
Published: September 2016

SUMMARY

Objective:
Amelogenesis imperfecta (AI) is a heterogenous genetic disorder that interferes with normal enamel formation in the absence of systemic disorders. The patients' main concerns are caries susceptibility, poor esthetics, and generalized sensitivity. There is a broad clinical spectrum, from discolorations to consequent enamel alterations. This case report describes the 15-year case study and the full-mouth rehabilitation of two siblings affected by a hypocalcified AI.

Clinical Considerations:
In these two patients, conservative care with stainless steel crowns and direct composite restorations was undertaken to restore function and esthetics and to reduce sensitivities in primary and mixed dentitions. The difficulties in monitoring resulted in severe infectious complications (dental abscess with cutaneous fistula), important dental defects, and loss of spaces with subsequent malocclusion. In the young adult dentition, they were treated by extractions, root canal therapies, and new restorations: stainless steel crowns for permanent molars, direct composite restorations (with strip crowns) for incisors and maxillary canines (to improve the crown morphology as well as to mask the discolorations and the malpositions), and adjusted composite crown molds using a thermoforming procedure for premolars and the mandibular canines. The main difficulties were rapid tooth surface loss, bonding to atypical enamel, developing dentition, long-term follow-up.

Conclusion:
Restoring function and esthetics in AI-affected patients is a challenge from primary to adult dentition. Early corrections are essential to avoid dental damage and for psychological benefits. This clinical report highlights the adhesive rehabilitation for anterior and premolar areas and the difficulty of patient follow-up.
Diagnosis of Paget-Schroetter Syndrome/Primary Effort Thrombosis in a Recreational Weight Lifter
Authors: DeLisa Lucia C. , Hensley Craig P. , Jackson Steven 
Published: September 2016

Abstract

Background and Purpose
Paget-Schroetter syndrome (PSS) is a rare condition of vein thrombosis that can be manifested in athletes and laborers who overuse their upper extremities. If diagnosed early, PSS can be managed and the symptoms can be fully reversed. Venous duplex ultrasound (US), the modality most commonly used to diagnose deep vein thrombosis (DVT), has high sensitivity and specificity for detecting DVT. This case report describes the differential diagnosis and management of PSS in a weight lifter.

Case Description
The patient was a 44-year-old man who had left upper extremity (UE) swelling and discoloration after performing an incline chest press 2 months earlier. He was referred to a physical therapist for the treatment of venous thoracic outlet syndrome because US imaging results were negative for DVT. The patient's signs and symptoms did not improve after 4 physical therapist treatment sessions.

Outcomes
Repeat US revealed multiple thrombi in the patient's UE. He underwent immediate thrombolysis and subsequent first rib removal and scalenectomy. Five months after the surgical intervention, the patient had returned to work as a truck driver without limitation of UE use, although he had not yet returned to weight lifting.

Discussion
Despite the facts that the patient was seen by several health care providers and that multiple US images were obtained, the patient's UE DVT was not detected. It is important for a clinician to consider venous pathology in the shoulder even if the results of diagnostic US imaging performed in the presence of UE swelling and pain have been negative. Timely diagnosis and management of PSS are necessary for optimal recovery.
Evolution of treatment and a detailed analysis of occlusion, recurrence, and clinical outcomes in an endovascular library of 260 dural arteriovenous fistulas
Authors: Gross Bradley A. , Albuquerque Felipe C. , Moon Karam , McDougall Cameron G. 
Published: September 2016

OBJECTIVEMany small series and technical reports chronicle the evolution of endovascular techniques for cranial dural arteriovenous fistulas (dAVFs) over the past 3 decades, but reports of large patient series are lacking. The authors provide a thorough analysis of clinical and angiographic outcomes across a large patient cohort.METHODSThe authors reviewed their endovascular database from January 1996 to September 2015 to identify patients harboring cranial dAVFs who were treated initially with endovascular approaches. They extracted demographic, presentation, angiographic, detailed treatment, and long-term follow-up data, and they evaluated natural history, initial angiographic occlusion, complications, recurrence, and symptomatic resolution rates.RESULTSAcross a cohort of 251 patients with 260 distinct dAVFs, the overall initial angiographic occlusion rate was 70%; recurrence or occult residual lesions were seen on subsequent angiography in 3% of cases. The overall complication rate was 8%, with permanent neurological complications occurring in 3% of cases. Among 102 patients with dAVFs without cortical venous reflux, rates of resolution/improvement of pulsatile tinnitus and ocular symptoms were 79% and 78%, respectively. Following the introduction of Onyx during the latter half of the study period, the number of treated dAVFs doubled; the initial angiographic occlusion rate increased significantly from 60% before the use of Onyx to 76% after (p = 0.01). In addition, during the latter period compared with the pre-Onyx period, the rate of dAVFs obliterated via a transarterial-only approach was significantly greater (43% vs 23%, p = 0.002), as was the number of dAVFs obliterated via a single arterial pedicle (29% vs 11%, p = 0.002).CONCLUSIONSOverall, in the Onyx era, the rate of initial angiographic occlusion was approximately 80%, as was the rate of meaningful clinical improvement in tinnitus and/or ocular symptoms after initial endovascular treatment of cranial dAVFs.
Studies on <i>In Vitro</i> Antioxidant Activity of Methanolic Extract and Fractions of <i>Ficus Hispida</i> Lin. Fruits
Authors: Hossain M. S. , Parvin S. , Dutta S. , Mahbub M. S. I. , Islam M. E. 
Published: September 2016

The present study was designed to confirm the traditional use of the fruits of Ficus hispida Linn. (Moraceae) as an antioxidant agent. Fruits of the plant extracted with methanol and crude methanol extract (CME) were further fractionated with n-hexane, chloroform, and ethyl acetate. All the fractions, n-hexane (NHF), chloroform (CHF), ethyl acetate (EAF), aqueous (AQF) and CME were preliminary screened for in vitro antioxidant activity and total phenolic and total flavonoid content. In DPPH radical scavenging assay, CME exhibited highest scavenging activity (IC50 = 11.20 µg/mL) as compared to other fractions. In this assay, IC50 of reference standard BHT was 5.10 µg/mL. The reducing power of the samples was in the order as AQF > CME > CHF > EAF > NHF. The results for hydrogen peroxide scavenging activity indicated that CME, EAF and AQF had almost the same scavenging activity except NHF. Total antioxidant capacity of CME and other fractions were ranked as CHF > AQF > CME > EAF > NHF. In the assay of antioxidant constituents (total phenol and total flavonoids content), the CME had highest phenolic and flavonoids content. The results indicate that Ficus hispida fruits could be considered as a potential source of natural antioxidant.
Building Chronic Kidney Disease Clinical Practice Guidelines Using the openEHR Guideline Definition Language
Authors: Hung Pei-Yuan , Lin Ching-Heng , Lo Ying-Chih , Liou Der-Ming 
Published: September 2016

SummaryBackground: As a result of the disease‘s high prevalence, chronic kidney disease (CKD) has become a global public health problem. A clinical decision support system that integrates with computer-interpretable guidelines (CIGs) should improve clinical outcomes and help to ensure patient safety.Objectives: The openEHR guideline definition language (GDL) is a formal language used to represent CIGs. This study explores the feasibility of using a GDL approach for CKD; it also attempts to identify any potential gaps between the ideal concept and reality.Methods: Using the Kidney Disease Improving Global Outcomes (KDIGO) anemia guideline as material, we designed a development workflow in order to establish a series of GDL guidelines. Focus group discussions were conducted in order to identify important issues related to GDL implementation.Results: Ten GDL guidelines and 37 archetypes were established using the KDIGO guideline document. For the focus group discussions, 16 clinicians and 22 IT experts were recruited and their perceptions, opinions and attitudes towards the GDL approach were explored. Both groups provided positive feedback regarding the GDL approach, but raised various concerns about GDL implementation.Conclusions: Based on the findings of this study, we identified some potential gaps that might exist during implementation between the GDL concept and reality. Three directions remain to be investigated in the future. Two of them are related to the openEHR GDL approach. Firstly, there is a need for the editing tool to be made more sophisticated. Secondly, there needs to be integration of the present approach into non openEHR-based hospital information systems. The last direction focuses on the applicability of guidelines and involves developing a method to resolve any conflicts that occur with insurance payment regulations.
THE METAL ABUNDANCES ACROSS COSMIC TIME (




) SURVEY. I. OPTICAL SPECTROSCOPY IN THE SUBARU DEEP FIELD
Authors: Ly Chun , Malhotra Sangeeta , Malkan Matthew A. , Rigby Jane R. , Kashikawa Nobunari , de los Reyes Mithi A. , Rhoads James E. 
Published: September 2016

ABSTRACT
Deep rest-frame optical spectroscopy is critical for characterizing and understanding the physical conditions and properties of the ionized gas in galaxies. Here, we present a new spectroscopic survey called “Metal Abundances across Cosmic Time” or






, which will obtain rest-frame optical spectra for ∼3000 emission-line galaxies. This paper describes the optical spectroscopy that has been conducted with MMT/Hectospec and Keck/DEIMOS for ≈1900 z = 0.1–1 emission-line galaxies selected from our narrowband and intermediate-band imaging in the Subaru Deep Field. In addition, we present a sample of 164 galaxies for which we have measured the weak [O iii]λ4363 line (66 with at least 3σ detections and 98 with significant upper limits). This nebular emission line determines the gas-phase metallicity by measuring the electron temperature of the ionized gas. This paper presents the optical spectra, emission-line measurements, interstellar properties (e.g., metallicity, gas density), and stellar properties (e.g., star formation rates, stellar mass). Paper II of the






survey (Ly et al.) presents the first results on the stellar mass–gas metallicity relation at z ≲ 1 using the sample with [O iii]λ4363 measurements.
197 CANDIDATES AND 104 VALIDATED PLANETS IN K2's FIRST FIVE FIELDS
Authors: Crossfield Ian J. M. , Ciardi David R. , Petigura Erik A. , Sinukoff Evan , Schlieder Joshua E. , Howard Andrew W. , Beichman Charles A. , Isaacson Howard , Dressing Courtney D. , Christiansen Jessie L. , Fulton Benjamin J. , Lépine Sébastien , Weiss Lauren , Hirsch Lea , Livingston John , Baranec Christoph , Law Nicholas M. , Riddle Reed , Ziegler Carl , Howell Steve B. , Horch Elliott , Everett Mark , Teske Johanna , Martinez Arturo O. , Obermeier Christian , Benneke Björn , Scott Nic , Deacon Niall , Aller Kimberly M. , Hansen Brad M. S. , Mancini Luigi , Ciceri Simona , Brahm Rafael , Jordán Andrés , Knutson Heather A. , Henning Thomas , Bonnefoy Michaël , Liu Michael C. , Crepp Justin R. , Lothringer Joshua , Hinz Phil , Bailey Vanessa , Skemer Andrew , Defrere Denis 
Published: September 2016

ABSTRACT
We present 197 planet candidates discovered using data from the first year of the NASA K2 mission (Campaigns 0–4), along with the results of an intensive program of photometric analyses, stellar spectroscopy, high-resolution imaging, and statistical validation. We distill these candidates into sets of 104 validated planets (57 in multi-planet systems),

false positives, and 63 remaining candidates. Our validated systems span a range of properties, with median values of R

P
=

, P =

days,

=

K, and Kp =

mag. Stellar spectroscopy provides precise stellar and planetary parameters for most of these systems. We show that K2 has increased by 30% the number of small planets known to orbit moderately bright stars (1–4 R
⊕, Kp = 9–13 mag). Of particular interest are

planets smaller than 2 R
⊕,

orbiting stars brighter than Kp = 11.5 mag, 5 receiving Earth-like irradiation levels, and several multi-planet systems—including 4 planets orbiting the M dwarf K2–72 near mean-motion resonances. By quantifying the likelihood that each candidate is a planet we demonstrate that our candidate sample has an overall false positive rate of 15%–30%, with rates substantially lower for small candidates (

) and larger for candidates with radii

and/or with

. Extrapolation of the current planetary yield suggests that K2 will discover between 500 and 1000 planets in its planned four-year mission, assuming sufficient follow-up resources are available. Efficient observing and analysis, together with an organized and coherent follow-up strategy, are essential for maximizing the efficacy of planet-validation efforts for K2, TESS, and future large-scale surveys.
THE SPITZER INFRARED SPECTROGRAPH SURVEY OF PROTOPLANETARY DISKS IN ORION A. I. DISK PROPERTIES
Authors: Kim K. H. , Watson Dan M. , Manoj P. , Forrest W. J. , Furlan Elise , Najita Joan , Sargent Benjamin , Hernández Jesús , Calvet Nuria , Adame Lucía , Espaillat Catherine , Megeath S. T. , Muzerolle James , McClure M. K. 
Published: September 2016

ABSTRACT
We present our investigation of 319 Class II objects in Orion A observed by Spitzer/IRS. We also present the follow-up observations of 120 of these Class II objects in Orion A from the Infrared Telescope Facility/SpeX. We measure continuum spectral indices, equivalent widths, and integrated fluxes that pertain to disk structure and dust composition from IRS spectra of Class II objects in Orion A. We estimate mass accretion rates using hydrogen recombination lines in the SpeX spectra of our targets. Utilizing these properties, we compare the distributions of the disk and dust properties of Orion A disks with those of Taurus disks with respect to position within Orion A (Orion Nebular Cluster [ONC] and L1641) and with the subgroups by the inferred radial structures, such as transitional disks (TDs) versus radially continuous full disks (FDs). Our main findings are as follows. (1) Inner disks evolve faster than the outer disks. (2) The mass accretion rates of TDs and those of radially continuous FDs are statistically significantly displaced from each other. The median mass accretion rate of radially continuous disks in the ONC and L1641 is not very different from that in Taurus. (3) Less grain processing has occurred in the disks in the ONC compared to those in Taurus, based on analysis of the shape index of the 10 μm silicate feature (F
11.3/F
9.8). (4) The 20–31 μm continuum spectral index tracks the projected distance from the most luminous Trapezium star, θ
1 Ori C. A possible explanation is UV ablation of the outer parts of disks.
Safety and Efficacy of Sofosbuvir plus Ledipasvir with and without Ribavirin for Chronic HCV Genotype-1 Infection: A Systematic Review and Meta-Analysis
Authors: Ahmed Hussien , Elgebaly Ahmed , Abushouk Abdelrahman Ibrahim , Hammad Ali Mohamed , Attia Attia , Negida Ahmed 
Published: September 2016

Background Ledipasvir and sofosbuvir are new direct-acting antiviral agents for patients with HCV infection. Ledipasvir inhibits the HCV non-structural 5A protein, while sofosbuvir is a nucleotide polymerase inhibitor. Many studies have evaluated the safety and efficacy of ledipasvir and sofosbuvir combination with and without ribavirin for patients with chronic HCV genotype-1. Methods A computer literature search of PubMed, SCOPUS, Web of Knowledge and Cochrane CENTRAL has been conducted. Studies were screened for eligibility and data were extracted. Sustained virological response (SVR) rate and commonly reported adverse events were pooled as risk ratio (RR) using Review Manager version 5.3 for windows and OpenMeta (Analyst) software. Results Eight randomized controlled trials ( n=1,892) were pooled in the final analysis. A 12-week ledipasvir and sofosbuvir regimen achieved SVR in 97.5% and 89% of non-cirrhotic and cirrhotic patients, respectively. A 24-week ledipasvir and sofosbuvir regimen achieved SVR in 99.6% and 92.6% in non-cirrhotic and cirrhotic patients, respectively. When ribavirin was added to the treatment regiment, the SVR did not differ significantly in either of the treatment regimens (12-week SVR: 93.9% versus 96.7%, RR=0.97, P=0.19 and 24-week SVR: 94.8% versus 97.2%, RR=0.98, P=0.24). Conclusions The combination of sofosbuvir and ledipasvir achieved high SVR rates (>90%) in both cirrhotic and non-cirrhotic patients with HCV genotype-1. The addition of ribavirin to this regimen did not signifcantly increase the SVR rates.
Treatments for Lupus Nephritis: A Systematic Review and Network Metaanalysis
Authors: Singh Jasvinder A. , Hossain Alomgir , Kotb Ahmed , Oliveira Ana , Mudano Amy S. , Grossman Jennifer , Winthrop Kevin , Wells George A. 
Published: September 2016

Objective.To compare benefits and harms of lupus nephritis (LN) induction and maintenance treatments.Methods.We performed a systematic review and Bayesian network metaanalyses of randomized controlled trials (RCT) of immunosuppressive drugs or corticosteroids (CS) in LN. OR and 95% credible intervals (CrI) were calculated.Results.There were 65 RCT that met inclusion and exclusion criteria. Significantly lower risk of endstage renal disease (ESRD; 17 studies) was seen with cyclophosphamide (CYC; OR 0.49, 95% CrI 0.25–0.92) or CYC + azathioprine (AZA; OR 0.18, 95% CrI 0.05–0.57) compared with standard-dose CS, and with high-dose (HD) CYC (OR 0.16, 95% CrI 0.03–0.61) or CYC + AZA (OR 0.10, 95% CrI 0.03–0.34) compared with HD CS. HD CS was associated with higher risk of ESRD compared with CYC (OR 3.59, 95% CrI 1.30–9.86), AZA (OR 2.93, 95% CrI 1.08–8.10), or mycophenolate mofetil (MMF; OR 7.05, 95% CrI 1.66–31.91). Compared with CS, a significantly higher proportion of patients had renal response (14 studies) when treated with CYC (OR 1.98, 95% CrI 1.13–3.52), MMF (OR 2.42, 95% CrI 1.27–4.74), or tacrolimus (TAC; OR 4.20, 95% CrI 1.29–13.68). No differences were noted for the risk of malignancy (15 studies). The risk of herpes zoster (17 studies) was as follows: OR (95% CrI) MMF versus CS 4.38 (1.02–23.87), CYC versus CS 6.64 (1.97–25.71), TAC versus CS 9.11 (1.13–70.99), and CYC + AZA versus CS 8.46 (1.99–43.61).Conclusion.Renal benefits and the risk of herpes zoster were higher for immunosuppressive drugs versus CS. Data on relative and absolute differences are now available, which can be incorporated into patient-physician discussions related to systemic lupus erythematosus medication use.
Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway
Authors: Adams Andrew B. , Ford Mandy L. , Larsen Christian P. 
Published: September 2016

Abstract
T cell activation is a complex process that requires multiple cell signaling pathways, including a primary recognition signal and additional costimulatory signals. TCR signaling in the absence of costimulatory signals can lead to an abortive attempt at activation and subsequent anergy. One of the best-characterized costimulatory pathways includes the Ig superfamily members CD28 and CTLA-4 and their ligands CD80 and CD86. The development of the fusion protein CTLA-4–Ig as an experimental and subsequent therapeutic tool is one of the major success stories in modern immunology. Abatacept and belatacept are clinically approved agents for the treatment of rheumatoid arthritis and renal transplantation, respectively. Future interventions may include selective CD28 blockade to block the costimulatory potential of CD28 while exploiting the coinhibitory effects of CTLA-4.
Precise Positioning of Terfenol-D Actuator by Eliminating the Heat Generated by Coil
Authors: Ahanpanjeh M. , Ghodsi M. , Hojjat Y. 
Published: September 2016

Large displacement, large generated stress and easy fabrication process lead to the large industrial use of the magnetostrictive materials. However, the thermal expansion restricts their application in precise positioning, which is about 12 and too much to be neglected. In this research, the cooling system was exploited in order to eliminate the joule heat generated by coils under the direct current and solve inaccuracy problem. The investigation consists of two parts; first was design and fabricating the actuator of Terfenol-D with length of 30mm which offers 10 displacement under the DC current of 1A, and second was the cooling system consisting of the thermoelectric cooler, heat sink and control circuit to inhibit the Terfenol-D temperature to be increased. Without the cooling system, as the time was going on and the Terfenol-D was warming up, after about two hours the displacement reached to 68 which deteriorated the accuracy of positioning significantly. By applying the cooling system, the displacement was maintained in 10 with the tolerance of , which realized the precise positioning by the Terfenol-D actuator.