bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of radiological risk to workers and members of the public from the operation of a groundwater treatment plant in Jordan
Authors: Alomari Ahmad , Carvalho Fernando P. , Saleh Muneer Aziz , Bilbeisi Eman , Abusalim Faten , Alsayaheen Amal , BaniKhalaf Refaat , Naser Heba Bani , Jaffal Alaa , Al-Sharat Diana , Abuzaitoun Ibrahim , Tarakhan Alaa , Naddaf Zainab , Alradaideh Jafar 
Published: October 2024

ABSTRACT

The study aimed to evaluate the radiation doses received by workers at a pilot water treatment plant (WTP) in Jordan. It also examined the concentrations of gross alpha, gross beta, and radium activities in both groundwater and treated water, along with a radiological risk assessment for the waste generated by the treatment process. The radioactivity levels of gross alpha and gross beta in the groundwater were found to exceed the established drinking water limits. In the pilot WTP, two methods were applied for water treatment, namely, ceramic ultra-filtration (CUF) and reverse osmosis (RO), both of which produced treated water that met drinking water quality standards. The annual effective dose from external radiation exposure to the WTP workers was found to be less than 0.007 mSv y−1 (during the filters backwash operation). However, the average annual dose from internal radiation due to inhalation of radon released from groundwater reached 3.2 mSv y−1, exceeding the 1 mSv y−1 limit. Therefore, monitoring radon levels in workplaces is recommended. Radioisotope concentrations in the waste (sludge) stockpiles exceeded clearance levels, requiring them to be treated as radioactive waste. Overall, the WTP successfully produced drinking water that met quality standards, and the methods used could be replicated in other locations.
Comparing the hydrological performance of blue green infrastructure design strategies in urban/semi-urban catchments for stormwater management
Authors: Adhikari Utsav , Broekhuizen I. , Pons V. , Sun Z. , Sjöman J. Deak , Randrup T. B. , Viklander M. , Blecken G.-T. 
Published: October 2024

ABSTRACT

Blue green infrastructure (BGI), in recent decades, have been increasingly recognized as robust stormwater control measures to reduce urban flooding, promote infiltration, and restore a catchment's flow to its pre-development stage. However, studies comparing the hydrological benefits of BGI alternatives at catchment scale are often limited to single catchment or single/few BGI options scaled over a catchment. This study designed a set of BGI alternatives as a combination of different BGI facilities in terms of the following: (a) spatial distribution scale (end-of-pipe vs. decentralized) and (b) naturalness scale (less engineered vs. more engineered), in three different urban catchments representing an inner city, a residential suburb, and a new urban housing. In addition, their hydrological performances were compared. A 10-year return period design rain and a continuous rain series of 11 years were modelled for each BGI alternative using the computer model stormwater management model (SWMM). It was observed that in most catchments, decentralized alternatives (both engineered and natural) showed better potential to reduce the magnitude and frequency of flooding than centralized measures. Similarly, the tested decentralized natural, less engineered alternatives showed higher potential to increase infiltration than the decentralized engineered alternatives in all three catchments. Meanwhile, infiltration-based BGI alternatives showed similar potential to mimic pre-development flow as other decentralized BGI alternatives.
Acceptability and Usability of Mobile Health Application for Enhancing Treatment Adherence in Latent TB Patients
Authors: Kumar Rohitashwa , Singhal Manmohan , Sinha Abhijeet P. , Islam KM Monirul 
Published: October 2024

Background:
Mobile health interventions showcase effectiveness for improving treatment adherence among Latent TB Infection (LTBI) patients. However, there
is a paucity of evidence regarding their acceptability and usability. This study aimed to assess the initial acceptability and usability of a mobile
health application that has been designed to ensure treatment adherence in LTBI patients.

Methods:
A descriptive study was conducted to assess the acceptability and usability of a mobile health application, “My Treatment Friend”. A total of 82
LTBI patients were selected, and access to the application was given to them. This application provides support to LTBI patients in reporting daily
medication and side effects. The basic demographic characteristics of the participants were collected through a Google form-based questionnaire.
The acceptability and usability of the application were assessed using the Likert scale questionnaire and SUS tool, with samples of n=44 and n=20
participants, respectively.

Results:
LTBI patients found the mobile application acceptable and feasible, with an SUS score of 73, which comes under Grade B as per the SUS score
sheet. The majority believed that the app was very simple to use and easy to understand. However, there is a requirement to add more features that
can enhance the acceptability and usability of the application.

Conclusion:
The study showed the importance and usefulness of mobile applications to assist LTBI patients in finishing their prescribed treatment courses of
action. Additionally, it highlights how crucial it is to build future applications using user-centered design. User-centered design may play an
important role in designing mobile applications and ensuring effective engagement and satisfaction among users.
Capgras Syndrome in Dementia: A Systematic Review of Case Studies
Authors: Margariti Charikleia , Mircea Margareta-Theodora 
Published: October 2024

Background:
In an ageing population, dementia has become an imminent healthcare
emergency. Capgras syndrome, the most common delusion of misidentification (DMS), is frequently
found alongside dementia. Previous research showed that Capgras syndrome has significant
negative effects on people living with dementia and their carers due to its complex presentation
and impact on their lives. This qualitative systematic review explores the evidence base of the
effective management and treatment of Capgras syndrome in dementia.

Aims:
As per our knowledge, this is the first systematic review exploring the symptomatology of
Capgras syndrome across different types of dementia. Additionally, it aims to identify the treatments
used and their efficacy.

Methods:
Four databases (EMBASE, MEDLINE, PsycINFO, and CINHAL) were screened in
March, 2023. Twenty-six studies met the inclusion criteria and were included in the review. Thematic
analysis was performed to explore and synthesise the qualitative findings of the studies.

Results:
Three conceptual themes were identified: diagnostic tools, Capgras syndrome symptomatology,
and Capgras syndrome treatment. Results showed that Capgras syndrome in dementia is
not diagnosed and treated in a standardised manner. Following the pharmacological intervention,
28% of cases showed resolution of symptoms, and another 28% experienced improvement. However,
7% of cases reported worsening symptoms, and 10.7% experienced no change. While some
patients had positive outcomes with specific medications, others either did not respond or experienced
a deterioration of their condition.

Conclusion:
The results highlight that there is no single treatment approach for Capgras syndrome
in people living with dementia. This underscores the need for person-centred care, where treatment
is tailored to individual needs. The review also reveals a heavy reliance on antipsychotic
medications and a noticeable lack of psychosocial interventions. Given the limited benefits and
significant risks associated with antipsychotics, future research should prioritise developing and
testing psychosocial approaches. Additionally, establishing standardised diagnostic criteria and
consistent outcome measures for Capgras syndrome in dementia is crucial for evaluating treatment
effectiveness and improving care.
Head Space GC-MS/MS Method for Quantification of Five Nitrosoamine- Genotoxic Impurities in Metformin HCl
Authors: Tummala Sambasiva Rao , Gorrepati Naveena , Tatapudi Hemant Kumar 
Published: October 2024

Background:
N-nitrosamines have recently been discovered in metformin hydrochloride
and other generic drugs. To quantify the five N-nitrosamines in metformin hydrochloride,
we devised sensitive and reliable multiple reactions monitoring mode-based GCMS/
MS technique, particularly, N-nitrosodiethy amine (NDEA), N-nitroso ethyl isopropylamine
(NEIPA), N-nitrosodiisopropylamine (NDIPA), N-nitrosodipropylamine (NDPA), as
well as N-nitrosodibutylamine (NDBA).

Objective:
To develop a sensitive, precise, and accurate MRM mode based GC-MS/MS method
for the quantification of five N-nitrosamines in metformin hydrochloride and valídate as per
ICH guidelines.

Methods:
The settings for mass spectrometry and gas chromatography were optimized. With
the linearity, sensitivity, specificity, accuracy, and precision of the parameter, the procedure
was as per the recommendation of ICH: International Council for Harmonization guidelines.

Results:
N-nitrosamines in metformin hydrochloride had detection and quantification limits of
0.001 ppm and 0.004 ppm, correspondingly. The obtained results were within the sensitivity
limitations issued by the US Food and Drug Administration. The calibration curve's regression
coefficients for five N-nitrosamines were over 0.99, demonstrating the process's good linearity.
The retrievals of N-nitrosamines in metformin hydrochloride between 97.1 – 127.4 %. The
RSD (Relative Standard Deviation) was lower than 10 % for both inter-day and intra-day precision
studies.

Conclusion:
The proposed method exhibited a rapid analysis capability, high accuracy, sensitivity,
and precision, making it a trustworthy method for monitoring N-nitrosamines in metformin
hydrochloride.
Hypoxia-inducible Factor-1α Pathway in Cerebral Ischemia: From Molecular Mechanisms to Therapeutic Targets
Authors: Sharma Veerta , Singh Thakur Gurjeet 
Published: October 2024

Introduction:
Ischemic injury to the brain can result in a variety of life-threatening conditions,
mortality, or varying degrees of disability. Hypoxia-inducible factor 1α (HIF 1α), an oxygen-
sensitive transcription factor that controls the adaptive metabolic response to hypoxia, is a critical
constituent of cerebral ischemia. It participates in numerous processes, such as metabolism, proliferation,
and angiogenesis, and plays a major role in cerebral ischemia.

Methods:
Through the use of a number of different search engines like Scopus, PubMed, Bentham,
and Elsevier databases, a literature review was carried out for investigating the pharmacological
modulation of HIF-1α pathways for the treatment of cerebral ischemia.

Results:
Various signalling pathways, such as Mitogen-activated protein kinase (MAPK), Janus kinase/
signal transducers and activators (JAK/STAT), Phosphoinositide-3-kinase (PI3-K), and cAMPresponse
element binding protein (CREB) play a vital role in modulation of HIF-1α pathway, which
helps in preventing the pathogenesis of cerebral ischemia.

Conclusion:
The pharmacological modulation of the HIF-1α pathway via various molecular signalling
pathways, such as PI3-K, MAPK, CREB, and JAK/STAT activators, offer a promising prospect
for future interventions and treatment for cerebral ischemia.
Exploring the Role of Deutetrabenazine in the Treatment of Chorea Linked with Huntington's Disease
Authors: Tripathi Siddhant , Sharma Yashika , Kumar Dileep 
Published: October 2024

Background:
This review investigates the efficacy of deutetrabenazine in the management
of chorea related to HD. Motor, psychological, and cognitive symptoms characterize HD, a
neurodegenerative disease. One prominent movement disorder associated with HD is chorea,
which results in uncontrollably jerky movements of the muscles. HD has no known cure; instead,
symptom management with a variety of medication options is the main goal. Effective management
is essential because chorea has a significant impact on patients' quality of life. Dutetrabenazine
is the first deuterated medication to receive approval from the US Food and Drug Administration
(FDA) for the therapeutic treatment of chorea in Huntington's disease (HD).

Objectives:
Treating chorea associated with HD may benefit from the use of deutetrabenazine.
The novel compound deutetrabenazine contains deuterium. It inhibits CYP2D6 metabolism, prolongs
the half-lives of active metabolites, and may cause persistent systemic exposure while maintaining
significant pharmacological action. Deutetrabenazine decreases the release of
monoamines, including dopamine, in the synaptic cleft by inhibiting the VMAT2 vesicular
monoamine transporter. For chorea, this mechanism has a therapeutic effect. For the treatment of
choreiform movement and tardive dyskinesia in HD, the FDA approved deutetrabenazine in 2017.

Conclusion:
Here we highlight, Deutetrabenazine as a promising new treatment for Huntington's
disease chorea, for patients with chorea, deutetrabenazine offers hope for an enhanced quality of
life. To completely understand its effectiveness and potential advantages, additional research is necessary,
including direct comparison studies, as a result of the mixed study results.
Optimalisasi sosiometri melalui bimbingan kelompok untuk meningkatkan motivasi melanjutkan studi pada siswa MTs
Authors: Prasetianto Takas 
Published: October 2024

Madrasah Mu’allimin merupakan sekolah kader 6 tahun yang membutuhkan komitmen dari jenjang MTs hingga MA. Penelitian ini dilakukan bertujuan mencari model untuk menekan angka siswa yang tidak melanjutkan MA dengan melakukan optimalisasi sosiometri melalui bimbingan kelompok untuk meninkatkan motivasi melanjutkan studi. Motivasi siswa menjadi penting untuk dilakukan sebab akan menjadi penentu sikap untuk melanjutkan studi atau tidak. Hal ini dikarenakan motivasi merupakan kekuatan dalam diri individu, yang menyebabkan individu tersebut bertindak dan berbuat (Uno, 2017). Bimbingan kelompok menjadi salah satu layanan bimbingan yang memungkinkan peserta didik secara bersama-sama mendapatkan pertimbangan dalam pengambilan keputusan (Sukardi, 2008). Sosiometri digunakan sebagai teknik pengumpulan data mengenai hubungan dan tingkah laku sosial siswa (Harum et al., 2015). Penggunaan sosiometri dalam studi ini menghasilkan siswa yang terisolir dan yang terpopuler (Devianti Sari, 2020). Dimana yang terpopuler biasanya akan memiliki pengaruh di kalangan siswa. Metode Penelitian Tindakan Kelas (PTK) memberikan tindakan berupa penggunaan instrumen sosiometri sebagai basis bimbingan kelompok pada siswa kelas 3G MTs. Peneliti memberikan penguatan motivasi dengan kolaborasi bersama siswa populer sebagai role model untuk memberikan penguatan kepada siswa lain. Tindakan ini telah menghasilkan peningkatan motivasi siswa sebanyak 6% yang akan melanjutkan studi ke jenjang MA. Peningkatan ini menandakan keberhasilan penggunaan sosiometri sebagai dasar bimbingan kelompok untuk penguatan komitmen motivasi keberlanjutan studi siswa. Kata kunci: sosiometri, bimbingan kelompok, motivasi, keberlanjutan studi, bimbingan konseling
Using the Person-Based Approach to Co-Create and Optimize an App-Based Intervention to Support Better Sleep for Adolescents in the United Kingdom: Mixed Methods Study
Authors: Bennett Sarah E , Johnston Milly H , Treneman-Evans Georgia , Denison-Day James , Duffy Anthony , Brigden Amberly , Kuberka Paula , Christoforou Nicholas , Ritterband Lee , Koh Jewel , Meadows Robert , Alamoudi Doaa , Nabney Ian , Yardley Lucy 
Published: October 2024

Background
Poor sleep is a common problem in adolescents aged 14 to 18 years. Difficulties with sleep have been found to have a bidirectional link to mental health problems.

Objective
This new research sought to involve young people in the co-creation of a new app, particularly those from underserved communities. The Sleep Solved app uses science-based advice to improve sleep-related behaviors and well-being. The app was developed using the person-based approach, underpinned by the social cognitive theory and the social-ecological model of sleep health.

Methods
Young people (aged 14-18 y) were recruited from across the United Kingdom to contribute to patient and public involvement (PPI) activities. In partnership with our peer researcher (MHJ), we used a multitude of methods to engage with PPI contributors, including web-based workshops, surveys, think-aloud interviews, focus groups, and app beta testing.

Results
A total of 85 young people provided PPI feedback: 54 (64%) young women, 27 (32%) young men, 2 (2%) genderfluid people, 1 (1%) nonbinary person, and 1 (1%) who reported “prefer not to say.” Their levels of deprivation ranged from among the 40% most deprived to the 20% least deprived areas. Most had self-identified sleep problems, ranging from 2 to 3 times per week to >4 times per week. Attitudes toward the app were positive, with praise for its usability and use of science-based yet accessible information. Think-aloud interviews and a focus group identified a range of elements that may influence the use of the app, including the need to pay attention to language choices and readability. User experiences in the form of narrated audio clips were used to normalize sleep problems and provide examples of how the app had helped these users.

Conclusions
Young people were interested in using an app to better support their sleep and mental health. The app was co-created with strong links to theory- and evidence-based sleep hygiene behaviors. Future work to establish the effectiveness of the intervention, perhaps in a randomized controlled trial, would provide support for potential UK-wide rollout.
Optimalisasi Strategi Idarah: Studi Kasus Pengelolaan Masjid Agung Kauman di Kota Semarang
Authors: Fadilah Miftahul , Asy'arie Bima Fandi , Latif Abdul 
Published: October 2024

A mosque is a building built with certain limits to worship Allah Almighty. In this modern era, the existence of a mosque also requires blood so that it can be managed optimally; the meaning of the blood has meanings called “management,” “arrangement,” and “management.” This research method is field research with a qualitative approach. As for how to collect data through observation, in-depth interviews, and documentation. This study aims to find out how (1) the blood strategy of the Great Mosque of Kauman Semarang and (2) Supporting and inhibiting factors in the blood of the Great Mosque of Kauman in Semarang City. The data obtained are: First, the blood of the Great Mosque of Kauman Semarang can be said to be good, because from the data collected with the daily mosque secretary there are security guards and marbots who handle mosque security and administration runs in an orderly manner. Second, the supporting factor of the Great Kauman Semarang mosque is its very strategic location, the management always considers that the mosque building is always in good condition, funding is obtained from other sources, and the mosque function is used for positive activities. However, the inhibiting factors that researchers found were a lack of coordination in physical management in the long run, youth reluctant to contribute, and delays in working on financial statements.
Cultural Heritage And City Branding: The Role of Masjid Agung Kubah Timah in Pangkalpinang
Authors: Sri Rezeki Nadia , Haprinda Monica , Juhaini Juhaini , Amin Mat , Tuha Panca Tuah , Aklil Maulan 
Published: October 2024

Bangka Island is famous as the largest tin producer in Indonesia. It has a distinctive history, culture, and religious diversity while upholding tolerance. However, the existence of tin on Bangka Island is not so felt as a symbol or characteristic in Pangkalpinang City as the Capital of the Province of Bangka Belitung Islands. Establishing the Great Mosque of the Tin Dome is currently the city branding of Pangkalpinang City. This study examines how the combination of resources, history, culture, and customs can become city branding. This research uses a descriptive qualitative method. Where the concentration of theoretical focus used is the development of a three-dimensional theoretical model that examines important elements in determining the elements, measurements, and equity of city branding. The data sources are obtained from interviews, secondary data, and also photographs of documentation. The results of the study show that the Great Mosque of the Tin Dome has met the requirements of city branding, namely 1) city brand elementshave met the history, process, graphics, and symbols; 2) city brand measurement is a process that starts from discussion, planning, narrative analysis, and visuals in its construction; and 3) city brand impact is very much felt by the identity, social and economic impact of the mosque's presence.
Pelatihan Pembuatan Ekoenzim dari Limbah Organik Rumah Tangga di Gampong Kopelma Darussalam, Banda Aceh
Authors: Chamzurni Tjut , Jauharlina Jauharlina , Sriwati Rina , Mukhriza Teuku , Oktarina Hartati 
Published: October 2024

Ecoenzyme is the result of fermentation of organic kitchen waste such as fruit and vegetable pulp, sugar and water. Ecoenzyme acts as various purposes such as pesticide and disinfectant. Therefore, we conducted community service activities aimed at providing a training in making ecoenzymes from household organic waste. Ecoenzyme-making training was given to the Family Welfare Development Group (PKK) in Gampong Kopelma Darussalam, Banda Aceh. The participants were lectured about ecoenzyme and its benefits and followed by discussion. It was then followed by a practical session on ecoenzymen-making activity. From this activity, the PKK group in Gampong Kopelma Darussalam, Banda Aceh, gained knowledge about a method to manage household organic waste become useful products. Furthermore, these skills can also be a source of additional income for local residents. During the training, the service team brought ready-made ecoenzymes and plants so they could provide examples of how to apply ecoenzymes to plants. The ecoenzyme and plants were given as souvenirs to the training participants.
Pengenalan Profesi Arsitek dan Perencana Kota melalui Kelas Hibrid Interaktif pada Masa Pandemi Covid-19 bagi Siswa SD di Banda Aceh
Authors: Agustina Sylvia , Edytia Muhammad Heru Arie , Zahrah Aghnia , Burhan Issana Meria , Harahap Sri Anggina 
Published: October 2024

This article reports on the design and implementation of thematic extracurricular activities for primary school students regarding the introduction of two professions : architect and urban planner. The program was carried out during the pandemic with all the limitations for direct physical interaction. This report elaborated methods for combining materials and ways to manage interactions in such situation. The combination of materials is expected to provide an introduction to the professions and introduce knowledge about the field in an interesting and age-appropriate way for children. It also act as a proxy to reach parents and schools with architectural design and urban planning issues. Implementation that combines offline and online methods is an alternative model for implementing other activities both during the pandemic and in normal situations. The results of the activity show that students and parents were very interested and actively involved. The main obstacle faced and worth anticipating in implementing similar activities is the level of familiarity with online interactions (with was new at the time) and finding mechanisms for activities to develop scientific interests at an early age, not incidentally but on a regular basis.