bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glass ceramics sealants for SOFC interconnects based on a high chromium sinter alloy
Authors: Schilm Jochen , Rost Axel , Kusnezoff Mihails , Megel Stefan , Michaelis Alexander 
Published: October 2017

AbstractThe operation of solid oxide fuel cells requires gas tight and stable sealing materials. Glass ceramic materials have been established to seal different stack designs and can be optimized to match the requirements of components and joining conditions. It is known that glass‐based sealants are sensitive to the formation of undesired chromia species in contact with ferritic steels used as interconnects. Their formation depends on the earth alkaline type and content in the glass as well as the chromium content of the interconnect. A robust interconnect material is the chromium‐based sinter alloy CFY with >93 wt.% chromium what in turn enforces the formation of chromia phases. SOFC stacks with chromium‐based interconnects and electrolyte supported cells with 10SCSZ electrolyte are candidates for SOFC systems with high efficiency in a wide power range. This study presents results on the development of sealing glasses adapted for the CFY by optimizing the glass components BaO, CaO, SiO2, and Al2O3. Depending properties like crystallization behavior, thermal expansion, adhesion and reactivity in contact with CFY have been regarded. The glass has been tested under operating conditions of SOFC (dual atmosphere, electric potentials) in samples as well as in real stacks. It has been shown that optimized glass compositions, especially regarding a limited BaO content combine a good joining behavior and minimized BaCrO4 formation in contact with the CFY alloy.
Comparing the performance of three panels rules of blood smear review criteria on an Italian multicenter evaluation
Authors: Pipitone S. , Germagnoli L. , Da Rin G. , Di Fabio A. , Fanelli A. , Fiorini F. , Francione S. , Marini A. , Papa A. , Benegiamo A. , Lari T. , Siviero F. , Lorubbio M. , Borin M. , Seghezzi M. , Ciardelli M. L. , Dima F. , Gioia M. , Buoro S. 
Published: October 2017

AbstractBackgroundThe aims of this study were to compare the diagnostic accuracy of blood smear review criteria, by means of three different panel rules, those proposed by: the International Consensus Group for Hematology [41‐ICGH rules], the Italian Survey [IS rules] and the Working Group on Hematology‐SIBioC (WGH) consensus rules (WGH rules).MethodsThis study is based on 2707 peripheral blood (PB) samples referred for routine hematological testing to the WGH‐associated laboratories displaced all over the Italian territory. The PB samples were processed on seven different hematology analyzers (HAs): Advia 2120i, XE‐2100, BC‐6800, ABX Pentra, XN‐1000, Cell‐DYN Sapphire, and DxH800, respectively. All the results provided by the HAs were analyzed through the application of three different blood smear review criteria: that is, the 41‐ICGH, IS, and WGH rules. Finally, data were compared with those obtained by optical microscopy (OM), as the current gold standard.ResultsThe overall the agreement OM classification with ICGH, IS, and WGH panel rules is 0.83, 0.83, and 0.85, respectively. The false negatives are 2.1%, 3.0%, and 2.9%, while false positives are 15.1%, 13.7%, and 11.7%, respectively. All the seven HAs showed variable interinstrument performance, as three different criteria for OM review were adopted on each of them from time to time.ConclusionThese results presented show that the customization of validation rules is necessary for enhancing the quality of hematological testing and optimizing workflow.
Comparison of an automated chemiluminescent assay to a manual ELISA assay for determination of von Willebrand Factor collagen binding activity on VWD plasma patients previously diagnosed through molecular analysis of VWF
Authors: Jousselme E. , Jourdy Y. , Rugeri L. , Négrier C. , Nougier C. 
Published: October 2017

AbstractIntroductionThe correct diagnosis and classification of VWD (von Willebrand disease) is crucial and must be optimized by including the collagen binding assay (VWF:CB). VWF:CB remains an under‐recognized tool, not fully automated. The objective of this study was to evaluate and to compare the previously evaluated automated chemiluminescent assay (HemosIL AcuStar VWF:CB) to the ELISA ASSERACHROM® assay used routinely in our laboratory in patients with molecular diagnosis of VWD.MethodsA plasma sample from 49 patients previously diagnosed with VWD (type 1; type 2A, type 2M, type 2B) through phenotype and VWF (von Willebrand factor) analysis and 15 healthy controls was analysed. The VWF ristocetin cofactor activity (VWF:Rco) and VWF antigen (VWF:Ag) were performed simultaneously on the VWD plasma samples, and VWF:CB/VWF:Ag ratios were calculated.ResultsThe AcuStar VWF:CB assay was quickly performed with Pearson's correlation coefficient (r²) of .9571 between assays and a bias of +5.1U/dL (AcuStar > ELISA). Discrepancies of VWF:CB/VWF:Ag ratio were observed in type 2M‐2A‐like VWD (ratio <0.6 with AcuStar assay in 4/5 samples).ConclusionThe AcuStar VWF:CB assay has demonstrated good performance to detect VWF mutational changes with capacity to discriminate quickly principal types of VWD.
A ten‐color tube with dried antibody reagents for the screening of hematological malignancies
Authors: Correia R. P. , Rajab A. , Bento L. C. , Alexandre A. M. , Vaz A. C. , Schimidell D. , Pedro E. C. , Perin F. S. , Nozawa S. T. , Barroso R. S. , Bacal N. S. 
Published: October 2017

AbstractIntroductionThe workflow in clinical flow cytometry laboratories must constantly be reviewed to develop technical procedures that improve quality and productivity and reduce costs. Using the Beckman Coulter dry coating technology, we customized a ten‐color tube with dried antibody reagents, designated the Duraclone screening tube (DST), for screening hematological malignancies. Here, we compared the applicability, clinical and numerical equivalence, and cost and time required for the technical procedures between the liquid reagents and the DST.MethodsThe DST contains CD4 + Kappa‐FITC, CD8 + Lambda‐PE, CD3 + CD14‐ECD, CD33‐PE‐Cy5.5, CD20 + CD56‐PE‐Cy7, CD34‐APC, CD19‐APC‐AlexaFluor700, CD10‐APC‐AlexaFluor750, CD5‐Pacific Blue, and CD45‐Krome Orange. We evaluated 20 bone marrow samples, 13 peripheral blood samples, 6 lymph node biopsy samples, 5 fine‐needle aspirate samples, 5 cerebrospinal fluid samples, and 1 pleural fluid sample.ResultsThe DST was useful for more than 60% of our samples. It was able to enumerate the majority of the populations in all types of samples with a statistically acceptable correlation with the liquid reagents. The use of the DST translated into significant time and cost savings of 15.8% and 12.3%, respectively, compared with the use of the liquid reagent. The cost was reduced by $14.36 per sample.ConclusionsThe DST is an efficient solution for screening hematological malignancies with improved quality, productivity, standardization, and sustainability. These improvements could benefit patients by providing faster diagnoses using a higher quality and lower cost reagent.
Pyroelectric properties of Mn‐doped Aurivillius ceramics with different pseudo‐perovskite layers
Authors: Tang Yanxue , Shen Zong‐Yang , Zhao Xiangyong , Wang Feifei , Shi Wangzhou , Sun Dazhi , Zhou Zhiyong , Zhang Shujun 
Published: October 2017

AbstractThe pyroelectric properties of Mn‐doped Aurivillius ceramics with different pseudo‐perovskite layers were investigated. The pyroelectric coefficients for 0.2 wt% Mn‐doped two‐layer CaBi2Nb2O9 (CBN–Mn), three‐layer Bi4Ti2.85Nb0.15O12 (BTN–Mn), and four‐layer CaBi4Ti3.95Nb0.05O15 (CBTN–Mn) ferroelectric ceramics were found to be on the order of 26.0, 54.4, 84.4 μC/m2K at room temperature, respectively. These values were closely associated with the number of octahedral layers in the pseudo‐perovskite blocks. The high pyroelectric coefficient, together with low dielectric permittivity and loss (tan δ < 0.003), results in to high figures of merit for the current responsivity, voltage responsivity, and detectivity. The excellent pyroelectric properties and high Curie temperatures (TC > 660°C) make the Aurivillius ceramics potential candidates for pyroelectric devices over a broad temperature range.
High‐volume continuous venovenous hemodiafiltration plus resin hemoperfusion improves severe metformin‐associated toxicity
Authors: Liu Shuangxin , Xu Lixia , Ma Jianchao , Huang Renwei , Lin Ting , Li Zhuo , Liang Huabang , Li Sijia , Li Ruizhao , Zhang Li , Tao Yiming , Li Zhilian , Chen Yuanhan , Ye Zhiming , Zhang Bin , Wang Wenjian , Xiao Houqing , Liang Xinling , Shi Wei 
Published: October 2017

AbstractWe present the case of a 42‐year‐old female patient who attempted suicide by taking approximately 100 tablets of metformin (500 mg). Laboratory tests revealed severe lactic acidosis with lactate levels of 24 mmol/L and pH of 7.09. The patient was treated with high‐volume continuous venovenous hemodiafiltration (CVVH) and resin‐sorbent hemoperfusion. Metformin concentrations were measured by high‐performance liquid chromatography during CVVH and hemoperfusion treatment. Before extracorporeal treatment, the plasma metformin concentration was 208.5 mg/L. After CVVH treatment for 24 h, the plasma metformin concentration had decreased to 13.9 mg/L. Resin‐based sorbent hemoperfusion plus CVVH treatment had reduced the metformin plasma concentration by 61.8% after 3 h. After 7 days, the patient's laboratory tests and clinical syndrome were improved, and she was discharged from hospital. We provide evidence that CVVH plus hemoperfusion is effective in eliminating metformins and metabolic products.
Terlipressin: Current and emerging indications in chronic liver disease
Authors: Papaluca Timothy , Gow Paul 
Published: October 2017

AbstractTerlipressin is an analogue of vasopressin that has potent vasoactive properties and has been available for use in most countries for nearly two decades. It has both established roles and emerging indications in the management of complications of decompensated chronic liver disease. We explore historic and emerging literature regarding the use of terlipressin for a range of indications including hepatorenal syndrome, portal hypertensive bleeding, and disruptions in sodium homeostasis. Novel methods of infusion‐based terlipressin administration including the beneficial effect in reduction of adverse events are explored, in addition to new indications for the use of terlipressin in decompensated cirrhosis in an outpatient setting.
Therapeutic potency of heat-shock protein-90 pharmacological inhibitors in the treatment of gastrointestinal cancer, current status and perspectives
Authors: Boroumand Nadia , Saghi Hossein , Avan Amir , Bahreyni Amirhossein , Ryzhikov Mikhail , Khazaei Majid , Hassanian Seyed Mahdi 
Published: October 2017

Abstract

Objectives
Heat-shock protein-90 (HSP90) chaperone machinery is critical to the folding, stability and activity of several client proteins including many responsible for tumour initiation, progression and metastasis. Overexpression of HSP90 is correlated with poor prognosis of GI cancer.

Key findings
Pharmacological inhibitors of HSP90 suppress tumorigenic effects of HSP90 by suppressing angiogenesis, survival, metastasis and drug resistance in GI cancer. This review summarizes the role of HSP90 inhibitors in the treatment of GI cancer.

Summary
We have presented different antitumour mechanisms of HSP90 inhibitors in cancer treatment. Suppression of HSP90 signalling via specific and novel pharmacological inhibitors is a potentially novel therapeutic approach for patients with GI cancer for a better understanding and hence a better management of this disease.
Coins, Forts and Commercial Exchanges in the Sixth‐ and Early Seventh‐Century Balkans
Authors: Curta Florin 
Published: October 2017

SummaryThe nature of settlements in the sixth‐century Balkans is a matter of current debate. Amphorae and hoards of iron implements and weapons have been discussed in relation to this controversy. A key problem is that of the use of coins in an economic environment without any large‐scale agricultural production. While hoards of coins have been analyzed in relation to the presence of the military in the Balkans, single finds of coins remain a category of archaeological evidence commonly neglected in discussions of the sixth‐century economy. The article offers an explanation connected with the quaestura exercitus implemented in 536, and its conclusion is that the small copper denominations discovered on hilltop sites in the Balkans were not obtained on the market (none existed in any of the many hilltop sites known so far), but piggybacked on transports of annona.
What are the Limits of Protest Theology? A Review EssayPious Irreverence: Confronting God in Rabbinic Judaism, DovWeiss, University of Pennsylvania Press, 2017 (ISBN 978‐0‐8122‐4835‐7), xii + 287pp., hb $69.95Facing the Abusing God: A Theology of Protest, David R.Blumenthal, Westminster/John Knox, Louisville, 1993 (ISBN 978‐0664254643), xxviii + 319 pp., pb $40
Authors: Blumenthal David R. 
Published: October 2017

AbstractPious Irreverence presents the classic rabbinic traditions that embody, or allow, protest of God's actions as well as the anti‐protest tradition that opposed criticism of God. By arranging this material chronologically, Weiss is able to analyze the development of both traditions. He concludes that the rabbis expanded the anthropomorphic and anthropopathic semantic field and, in so doing, allowed very deep criticism of God as a sign of God's intimacy with the Jewish people. Blumenthal, reflecting on Facing the Abusing God: A Theology of Protest, twenty‐five years after its publication, in light of the new material brought forth by Weiss, enters into a dialogue in which he shares second thoughts about his earlier work.
Carbonate and silicate biomineralization in a hypersaline microbial mat (Mesaieed sabkha, Qatar): Roles of bacteria, extracellular polymeric substances and viruses
Authors: Perri Edoardo , Tucker Maurice E. , Słowakiewicz Mirosław , Whitaker Fiona , Bowen Leon , Perrotta Ida D. 
Published: October 2017

AbstractIn a modern peritidal microbial mat from Qatar, both biomediated carbonates and Mg‐rich clay minerals (palygorskite) were identified. The mat, ca 5 cm thick, shows a clear lamination reflecting different microbial communities. The initial precipitates within the top millimetres of the mat are composed of Ca–Mg–Si–Al–S amorphous nanoparticles (few tens of nanometres) that replace the ultrastructure of extracellular polymeric substances. The extracellular polymeric substances are enriched in the same cations and act as a substrate for mineral nucleation. Successively, crystallites of palygorskite fibres associated with carbonate nanocrystals develop, commonly surrounding bacterial bodies. Micron‐sized crystals of low‐Mg calcite are the most common precipitates, together with subordinate aragonite, very high‐Mg calcite/dolomite and ankerite. Pyrite nanocrystals and framboids are present in the deeper layers of the mat. Calcite crystallites form conical structures, circular to triangular/hexagonal in cross‐section, evolving to crystals with rhombohedral terminations; some crystallite bundles develop into dumb‐bell and stellate forms. Spheroidal organo‐mineral structures are also common within the mat. Nanospheres, a few tens of nanometres in diameter, occur attached to coccoid bacteria and within their cells; these are interpreted as permineralized viruses and could be significant as nuclei for crystallite‐crystal precipitation. Microspheres, 1 to 10 μm in diameter, result from intracellular permineralization within bacteria or the mineralization of the bacteria themselves. Carbonates and clay minerals are commonly aggregated to form peloids, tens of microns in size, surrounded by residual organic matter. Magnesium silicate and carbonate precipitation are likely to have been driven by pH – saturation index – redox changes within the mat, related to microenvironmental chemical changes induced by the microbes – extracellular polymeric substances – viruses and their degradation.
The Evolving Singaporean Welfare State
Authors: Lee Soo Ann , Qian Jiwei 
Published: October 2017

AbstractEast Asian welfare states are regarded as a welfare regime that supports ‘productivism’, in which social policies play a supportive role for economic policies. However, recent dramatic social and economic challenges persist, including ageing and change of labour market structure. Whether welfare states in East Asia can evolve with these changes remains uncertain. The social policies in Singapore, which have been designed to accommodate the political rationale and economic growth strategy in the economic, political and social contexts, are discussed in this article. This research contributes to the literature by interpreting the welfare regime in Singapore from a broad and dynamic political and economic context. Furthermore, this article considers the policy responses in Singapore to the change of the economic and social conditions in evolving welfare states by reviewing recent developments of the country's social policies.
Identification of Chlamydomonas reinhardtii endogenous genic flanking sequences for improved transgene expression
Authors: López‐Paz Cristina , Liu Dianyi , Geng Sa , Umen James G. 
Published: October 2017

SummaryChlamydomonas reinhardtii is a unicellular green alga that has attracted interest due to its potential biotechnological applications, and as a model for algal biofuel and energy metabolism. Despite all the advantages that this unicellular alga offers, poor and inconsistent expression of nuclear transgenes remains an obstacle for basic and applied research. We used a data‐mining strategy to identify highly expressed genes in Chlamydomonas whose flanking sequences were tested for the ability to drive heterologous nuclear transgene expression. Candidates identified in this search included two ribosomal protein genes, RPL35a and RPL23, and ferredoxin, FDX1, whose flanking regions including promoters, terminators and untranslated sequences could drive stable luciferase transgene expression to significantly higher levels than the commonly used Hsp70A‐RBCS2 (AR) hybrid promoter/terminator sequences. The RPL23 flanking sequences were further tested using the zeocin resistance gene sh‐ble as a reporter in monocistronic and dicistronic constructs, and consistently yielded higher numbers of zeocin‐resistant transformants and higher levels of resistance than AR‐ or PSAD‐based vectors. Chlamydomonas RPL23 sequences also enabled transgene expression in Volvox carteri. Our study provides an additional benchmark for strong constitutive expression of transgenes in Chlamydomonas, and develops a general approach for identifying flanking sequences that can be used to drive transgene expression for any organism where transcriptome data are available.
Experimental Determination of the Effect of Bow Shape on the Wave Drift Load
Authors: Boorsma Anne , Aalbers Kees , van ‘t Veer Riaan , Huijsmans René 
Published: October 2017

In the last forty years wave drift loads have been calculated with methods based on the near-field theory (hull pressure integration, Pinkster [4]) and/or the far field method (linear momentum theory). Both methods use linear theory and through its formulation ignore the ship’s hull form above the mean water line. It is evident that in survival sea-states the small motion assumptions are violated and the hull form above the mean water line can affect the motion characteristics of the ship and the drift loads. In order to get more insight in this effect, SBM has conducted a systematic model test campaign at the TU Delft using an Aframax size tanker.
The campaign included tests with two different bow shapes: the original bow with flare, and a wall-sided bow. Horizontal loads on the complete vessel and a section of the bow only were measured accompanied by measurements of the ship motions and relative wave heights. Measurements were performed for various wave heights and periods. Numerous repeat tests were conducted to establish the confidence level of the measurement data.
Measurements have shown motions and relative wave heights are dependent on wave height. It was suggested that viscous damping may play a part in this.
The relative wave height in high waves is affected by bow shape; namely the finite draft, the flare and the bulb. How this departure from linear theory affects the forces on the vessel should be investigated further.
Thruster-Wave Interaction During DP Stationkeeping: Model Tests in Open Water and Under a Ship Hull
Authors: Cozijn Hans , Choi Jin Woo , You Young-Jun 
Published: October 2017

Wave orbital motions may cause variations in the inflow conditions of thrusters, resulting in variations in thrust and torque. Physical scale model tests were carried out to investigate these thruster-wave interaction effects, with an azimuthing thruster running at constant RPMs. The observed effects include a change in mean thrust and torque values, as well as wave frequency variations. The test conditions were systematically varied to investigate the effects of the incoming waves, the presence of the hull and the vessel motions.
First, measurements were carried out on an azimuthing thruster in open water conditions. The thrust and torque in regular waves were compared with bollard pull conditions.
Second, measurements were carried out on the azimuthing thruster under the hull of a vessel, which was rigidly connected to the basin carriage. Again, regular wave tests were performed, showing the effect of the presence of the hull.
Third, measurements were carried out on the same azimuthing thruster under the hull of the vessel in a soft-mooring system. This kept the vessel in position and at the required heading, while allowing unrestricted wave frequency motions. Again, regular wave tests were performed, now showing the combined effects of the passing waves, the presence of the vessel hull and the vessel motions.
Study of Offshore Jacket Platform Attached With Tuned Liquid Column Gas Damper
Authors: Sathish P. , Sajith A. S. 
Published: October 2017

With increase in need of energy, scarcity of natural resources also increases. Need for energy has led the people to move into the ocean since they contain abundant natural resources. Offshore platforms play a major role in exploring and exploiting these resources. Jacket platform being a fixed offshore jacket platform is used in water depths 300 to 400 m. The study of behavior of these offshore structures is vital part in the design since they are subjected to dynamic loading of waves, wind, earthquake, ice etc. These structures in hostile environment are subjected to heavy loads. There is need for controlling the response of these structures. This can be achieved by providing external dampers.
There are various dampers available to control the response of structures. Tuned liquid dampers (TLD)s and Tuned Liquid Column Damper (TLCD)s use liquid inside to tune its frequency to natural frequency of structure. Tuned Liquid Column Gas Damper (TLCGD) is latest version of dampers. It has a unique flexibility of tuning frequency compared to all other dampers.
In the present study, jacket platform is modeled as Multi degree of freedom (MDOF) system. At later stage, for simplistic analysis, MDOF system is reduced to SDOF system using static condensation. Performance of TLCGD for both the systems is compared. Airy’s wave theory is used for wave force excitation. Equations of motions for Jacket platform models attached with TLCGD are developed and solved using Newmarks β method in MATLAB. TLCGD is found to be very flexible in tuning the frequency and maximum reductions in response, 21.3% and 23.14% are observed at 0.3 MPa for MDOF and SDOF systems respectively. Work done shows that the results for MDOF and SDOF are comparable and hence, jacket as SDOF can be used for analysis for reducing the complexities.