bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rethinking the origins of autism: Ida Frye and the unraveling of children's inner world in the Netherlands in the late 1930s
Authors: Van Drenth Annemieke 
Published: December 2017

AbstractHistoriographies on the phenomenon of “autism” display Leo Kanner and Hans Asperger as the great pioneers. The recent controversy on who was first in “discovering” autism urges research into the question of how scientific discoveries relate to processes of academic reflection and social intervention. The Netherlands provide an interesting case in pioneering work in autism, since Dutch experts described autism in children already in the late 1930s, preceding the first publications on autism in children by Kanner and Asperger. This paper examines the Dutch origins of autism by focusing on Ida Frye's contribution to the teamwork at the Paedological Institute in Nijmegen, which resulted in descriptions of children with autism. The theoretical aim of this paper is to underline the importance of the productive interplay between social interventions and scientific efforts concerning the complex inner world of special children.
From Hohenschönhausen to Guantanamo Bay: Psychology's role in the secret services of the GDR and the United States
Authors: Michels Moritz , Wieser Martin 
Published: December 2017

AbstractThis paper presents a historical analysis of the genesis, context, and function of “Operative Psychology,” a little‐known branch of applied psychology developed by employees of the Ministry of State Security in the German Democratic Republic. For 25 years, theories and practices of Operative Psychology were taught to elite agents at the Juridical Academy in Potsdam, introducing them to various “silent” psychological techniques of persuasion, interrogation, and repression. After highlighting the economic and political context that increased the need for “silent” techniques of observation and repression, an overview of the topics that were taught and researched at the chair for Operative Psychology is given. Examples of how these techniques were put into practice are provided and the consequences for the victims of Operative Psychology are discussed. Furthermore, commonalities and differences between Operative Psychology and the use of psychological torture by the CIA during the “war on terror” are discussed and questions regarding the relation between methodological and moral strategies of justification are addressed.
Roles of neutrophils in cancer growth and progression
Authors: Galdiero Maria Rosaria , Varricchi Gilda , Loffredo Stefania , Mantovani Alberto , Marone Gianni 
Published: December 2017

Abstract
Chronic inflammation is a well-known tumor-enabling capacity, which allows nascent tumors to acquire all the hallmark capabilities, including the escape from immunosurveillance. Soluble and cellular inflammatory mediators constitute the complex network of the tumor microenvironment, in which tumors grow and with which constantly interact. Myeloid cells (e.g., tumor associated macrophages) are pivotal players of the tumor microenvironment and are characterized by plasticity, which consists of the ability to acquire distinct phenotypes in response to the microenvironment in which they reside. Neutrophils are emerging as important players of tumor microenvironment, given their heterogeneity and plasticity. Increasing evidence suggests a dual role for neutrophils in modulating tumor behavior and highlights the need for a reassessment of neutrophil functions in cancer initiation and progression.
Evaluation of Umbilical Vein Blood Volume Flow in Preeclampsia by Angle‐Independent 3D Sonography
Authors: Pinter Stephen Z. , Kripfgans Oliver D. , Treadwell Marjorie C. , Kneitel Anna W. , Fowlkes J. Brian , Rubin Jonathan M. 
Published: December 2017

ObjectivesTo investigate the association between umbilical vein blood volume flow and the condition of preeclampsia in an at‐risk maternal patient cohort. Umbilical vein volume flow was quantified by a 3‐dimensional (3D) sonographic technique that overcomes several limitations of standard sonographic flow measurement methods.MethodsA total of 35 patients, each with a singleton pregnancy, were recruited to provide 5 patients with preeclampsia, derived as a subset from a 26‐patient at‐risk group, and 9 patients with normal pregnancies. An ultrasound system equipped with a 2.0–8.0‐MHz transducer was used to acquire multivolume 3D color flow and power mode data sets to compute the mean umbilical vein volume flow in patients with normal pregnancies and preeclampsia.ResultsThe gestational ages of the pregnancies ranged from 29.7 to 34.3 weeks in the patients with preeclampsia and from 25.9 to 34.7 weeks in the patients with normal pregnancies. Comparisons between patients with normal pregnancies and those with preeclampsia showed weight‐normalized flow with a moderately high separation between groups (P = .11) and depth‐corrected, weight‐normalized flow with a statistically significant difference between groups (P = .035). Umbilical vein volume flow measurements were highly reproducible in the mean estimate, with an intrapatient relative SE of 12.1% ± 5.9% and an intrameasurement relative SE of 5.6% ± 1.9 %. In patients who developed pregnancy‐induced hypertension or severe pregnancy‐induced hypertension, umbilical vein volume flow suggested gestational hypertensive disorder before clinical diagnosis.ConclusionsResults indicate that mean depth‐corrected, weight‐normalized umbilical vein volume flow is reduced in pregnancies complicated by preeclampsia and that volume flow may indicate hypertensive disorder earlier in gestation. Volume flow measurements are highly reproducible, and further study in a larger clinical population is encouraged to determine whether 3D volume flow can complement the management of preeclampsia and, in general, at‐risk pregnancy.
The effectiveness of platelet‐rich plasma in an anosmia‐induced mice model
Authors: Yasak Ahmet Gorkem , Yigit Ozgur , Araz Server Ela , Durna Dastan Sevgi , Gul Mehmet 
Published: December 2017

ObjectiveIn this study, we aimed to functionally and morphologically demonstrate the effectiveness of platelet‐rich plasma (PRP) on anosmia in a mouse model of anosmia.Study DesignAnimal study.MethodsA total of 16 male mice were included. When selecting the mice, the food‐finding test (FFT) was used to make sure that the animals could smell, and anosmia was induced by administration of intraperitoneal 3‐methylindole. The mice were randomly divided into two groups of eight (groups A and B). After 1 week, topical PRP was administered to the mice in group A and topical saline was administered to the mice in group B. The FFT was again administered at 7, 14, and 21 days. The mice were sacrificed on day 21, the olfactory neuroepithelium was histopathologically examined, and the epithelial damage scores and epithelial thickness were measured.ResultsAfter topical administration of PRP and saline, the difference in the average FFT values of the groups was statistically significant at 7, 14, and 21 days (P < 0,005). During the histopathological examination, the epithelial damage score was statistically significantly lower in the PRP group (P = 0.001) than in the saline group, and epithelial thickness was statistically significantly greater in the PRP group compared to the saline group (P = 0.003).ConclusionWe showed that PRP administration has a curative effect on olfactory functions in an anosmia‐induced mice model. However, there is a need for further research before PRP can be considered for use in patients with anosmia in clinical practice.Level of EvidenceNA. Laryngoscope, 128:E157–E162, 2018
The diagnostic pathway of oropharyngeal squamous cell carcinoma in a large U.S. healthcare system
Authors: Gilde Jason , Song Brian , Masroor Farzad , Darbinian Jeanne A. , Ritterman Weintraub Miranda L. , Salazar James , Yang Eleanor , Gurushanthaiah Deepak , Wang Kevin H. 
Published: December 2017

ObjectiveTo examine the current diagnostic pathway of oropharyngeal squamous cell carcinoma (OPSCC) and identify factors associated with time to diagnosis.MethodsRetrospective cohort study of patients with OPSCC in an integrated healthcare system from January 1, 2013, to December 31, 2013. Patient demographics, tobacco and alcohol use, chief complaint, tumor stage, human papilloma virus (HPV) status, physician factors (diagnosis, antibiotic prescription, performance of endoscopic exam, biopsy), and time intervals were examined. Time variations by patient characteristics and physician practice were assessed.ResultsWe identified 152 patients with OPSCC. Of those, 90% had stage III to IV disease. The cohort was largely male (85%), white (79%), with HPV‐positive tumors (84%). Most common chief complaints were neck mass (52%) and sore throat (20%). Among those with neck a mass, 94% had HPV‐positive tumors. Prescription of antibiotics was associated with longer time to first otolaryngology evaluation. Median time from symptom onset to first primary care physician (PCP) contact was 3.0 weeks; from PCP to otolaryngologist was 1.1 weeks, and from otolaryngologist to tissue diagnosis was 0.4 weeks. At the first otolaryngology visit, 82% underwent in‐office flexible endoscopy and 58% had same‐day biopsy, resulting in rapid time to tissue diagnosis. Diagnostic time intervals did not differ by HPV status.ConclusionThe overall diagnostic process was efficient, although initial antibiotic treatment resulted in longer time to first otolaryngology visit. Tumor HPV status was associated with presenting findings but not time to diagnosis. The variation in diagnostic delay time and impact on survival outcomes is unknown and merits further investigation.Level of Evidence4. Laryngoscope, 1867–1873, 2018
Sustainable open access for scholarly journals in 6 years – the incubator model at Utrecht University Library Open Access Journals
Authors: Sondervan Jeroen , Stigter Fleur 
Published: December 2017

Key points
Humanities and the social science journals need flexible funding models.
Pragmatism and collaboration are key to transforming traditional publishing initiatives.
The Uopen Journals model sets a 6‐year development target for developing sustainable journals.
Actively involved editors are key to a journal's success.
Thermophilic bacterial communities inhabiting the microbial mats of “indifferent” and chalybeate (iron‐rich) thermal springs: Diversity and biotechnological analysis
Authors: Selvarajan Ramganesh , Sibanda Timothy , Tekere Memory 
Published: December 2017

AbstractMicrobial mats are occasionally reported in thermal springs and information on such mats is very scarce. In this study, microbial mats were collected from two hot springs (Brandvlei (BV) and Calitzdorp (CA)), South Africa and subjected to scanning electron microscopy (SEM) and targeted 16S rRNA gene amplicon analysis using Next Generation Sequencing (NGS). Spring water temperature was 55°C for Brandvlei and 58°C for Calitzdorp while the pH of both springs was slightly acidic, with an almost identical pH range (6.2–6.3). NGS analysis resulted in a total of 4943 reads, 517 and 736 OTUs for BV and CA at, respectively, a combined total of 14 different phyla in both samples, 88 genera in CA compared to 45 in BV and 37.64% unclassified sequences in CA compared to 27.32% recorded in BV. Dominant bacterial genera in CA microbial mat were Proteobacteria (29.19%), Bacteroidetes (9.41%), Firmicutes (9.01%), Cyanobacteria (6.89%), Actinobacteria (2.65%), Deinococcus‐Thermus (2.57%), and Planctomycetes (1.94%) while the BV microbial mat was dominated by Bacteroidetes (47.3%), Deinococcus‐Thermus (12.35%), Proteobacteria (7.98%), and Planctomycetes (2.97%). Scanning electron microscopy results showed the presence of microbial filaments possibly resembling cyanobacteria, coccids, rod‐shaped bacteria and diatoms in both microbial mats. Dominant genera that were detected in this study have been linked to different biotechnological applications including hydrocarbon degradation, glycerol fermentation, anoxic‐fermentation, dehalogenation, and biomining processes. Overall, the results of this study exhibited thermophilic bacterial community structures with high diversity in microbial mats, which have a potential for biotechnological exploitation.
Interventions developed with the Intervention Mapping protocol in the field of cancer: A systematic review
Authors: Lamort‐Bouché Marion , Sarnin Philippe , Kok Gerjo , Rouat Sabrina , Péron Julien , Letrilliart Laurent , Fassier Jean‐Baptiste 
Published: December 2017

AbstractObjectivesThe Intervention Mapping (IM) protocol provides a structured framework to develop, implement, and evaluate complex interventions. The main objective of this review was to identify and describe the content of the interventions developed in the field of cancer with the IM protocol. Secondary objectives were to assess their fidelity to the IM protocol and to review their theoretical frameworks.MethodsMedline, Web of Science, PsycINFO, PASCAL, FRANCIS, and BDSP databases were searched. All titles and abstracts were reviewed. A standardized extraction form was developed. All included studies were reviewed by 2 reviewers blinded to each other.ResultsSixteen studies were identified, and these reported 15 interventions. The objectives were to increase cancer screening participation (n = 7), early consultation (n = 1), and aftercare/quality of life among cancer survivors (n = 7). Six reported a complete participatory planning group, and 7 described a complete logic model of the problem. Ten studies described a complete logic model of change. The main theoretical frameworks used were the theory of planned behaviour (n = 8), the transtheoretical model (n = 6), the health belief model (n = 6), and the social cognitive theory (n = 6). The environment was rarely integrated in the interventions (n = 4). Five interventions were reported as effective.ConclusionsCulturally relevant interventions were developed with the IM protocol that were effective to increase cancer screening and reduce social disparities, particularly when they were developed through a participative approach and integrated the environment. Stakeholders' involvement and the role of the environment were heterogeneously integrated in the interventions.
Penetration into membrane of amino‐terminal region of SecA when associated with SecYEG in active complexes
Authors: Findik Bahar T. , Smith Virginia F. , Randall Linda L. 
Published: December 2017

AbstractThe general secretory (Sec) system of Escherichia coli translocates both periplasmic and outer membrane proteins through the cytoplasmic membrane. The pathway through the membrane is provided by a highly conserved translocon, which in E. coli comprises two heterotrimeric integral membrane complexes, SecY, SecE, and SecG (SecYEG), and SecD, SecF, and YajC (SecDF/YajC). SecA is an associated ATPase that is essential to the function of the Sec system. SecA plays two roles, it targets precursors to the translocon with the help of SecB and it provides energy via hydrolysis of ATP. SecA exists both free in the cytoplasm and integrally membrane associated. Here we describe details of association of the amino‐terminal region of SecA with membrane. We use site‐directed spin labelling and electron paramagnetic resonance spectroscopy to show that when SecA is co‐assembled into lipids with SecYEG to yield highly active translocons, the N‐terminal region of SecA penetrates the membrane and lies at the interface between the polar and the hydrophobic regions, parallel to the plane of the membrane at a depth of approximately 5 Å. When SecA is bound to SecYEG, preassembled into proteoliposomes, or nonspecifically bound to lipids in the absence of SecYEG, the N‐terminal region penetrates more deeply (8 Å). Implications of partitioning of the SecA N‐terminal region into lipids on the complex between SecB carrying a precursor and SecA are discussed.
Fast, autonomous flight in GPS‐denied and cluttered environments
Authors: Mohta Kartik , Watterson Michael , Mulgaonkar Yash , Liu Sikang , Qu Chao , Makineni Anurag , Saulnier Kelsey , Sun Ke , Zhu Alex , Delmerico Jeffrey , Karydis Konstantinos , Atanasov Nikolay , Loianno Giuseppe , Scaramuzza Davide , Daniilidis Kostas , Taylor Camillo Jose , Kumar Vijay 
Published: December 2017

AbstractOne of the most challenging tasks for a flying robot is to autonomously navigate between target locations quickly and reliably while avoiding obstacles in its path, and with little to no a priori knowledge of the operating environment. This challenge is addressed in the present paper. We describe the system design and software architecture of our proposed solution and showcase how all the distinct components can be integrated to enable smooth robot operation. We provide critical insight on hardware and software component selection and development and present results from extensive experimental testing in real‐world warehouse environments. Experimental testing reveals that our proposed solution can deliver fast and robust aerial robot autonomous navigation in cluttered, GPS‐denied environments.
Effects of Extreme Hydrologic Regimes on Juvenile Chinook Salmon Prey Resources and Diet Composition in a Large River Floodplain
Authors: Goertler Pascale , Jones Kristopher , Cordell Jeffery , Schreier Brian , Sommer Ted 
Published: December 2017

AbstractClimate and hydrologic variability are defining characteristics of California rivers. Recently, the region experienced an unprecedented drought, and the probability of similarly warm, dry conditions is predicted to increase. In addition to warming air and water temperatures, climate change projections predict increased flooding and sea level rise, likely aggravating the water resource issues that already challenge the western United States. Water managers balance many public interests, including the conservation of native fishes, such as the Chinook Salmon Oncorhynchus tshawytscha. Given projected changes in climate and hydrology, there is an urgent need to understand how salmon respond to these conditions. In this study, we examined how young salmon responded to extreme drought (2012–2015) versus flood (1998–1999) conditions in the Yolo Bypass, a floodplain–tidal slough complex of the Sacramento River, California. We found that the diets of juvenile Chinook Salmon were dominated by aquatic–riparian insects during flooding and were dominated by zooplankton during the drought. Although juvenile salmon that were caught during the drought seemed to have eaten a higher number of prey items on average, they also had higher metabolic costs. Therefore, it is likely that juvenile salmon must augment their foraging behavior to offset higher temperatures and prey shifts. Finally, preferentially consumed, calorically valuable prey (i.e., larger zooplankton and aquatic–riparian insects) have become rare due to habitat degradation and biological invasions, and resource managers must consider re‐establishing productive off‐channel habitats, such as riparian corridors, floodplains, and wetlands.
Dermal fibroblast in cutaneous development and healing
Authors: Thulabandu Venkata , Chen Demeng , Atit Radhika P. 
Published: December 2017

The skin is the largest organ of the body and is composed of two layers: the overlying epidermis and the underlying dermis. The dermal fibroblasts originate from distinct locations of the embryo and contain the positional identity and patterning information in the skin. The dermal fibroblast progenitors differentiate into various cell types that are fated to perform specific functions such as hair follicle initiation and scar formation during wound healing. Recent studies have revealed the heterogeneity and plasticity of dermal fibroblasts within skin, which has implications for skin disease and tissue engineering. The objective of this review is to frame our current understanding and provide new insights on the origin and differentiation of dermal fibroblasts and their function during cutaneous development and healing. WIREs Dev Biol 2018, 7:e307. doi: 10.1002/wdev.307This article is categorized under:

Birth Defects > Organ Anomalies
Signaling Pathways > Cell Fate Signaling
Adult Stem Cells, Tissue Renewal, and Regeneration > Regeneration
Nervous System Development > Vertebrates: Regional Development
A history of genome editing in Saccharomyces cerevisiae
Authors: Alexander William G. 
Published: December 2017

AbstractGenome editing is a form of highly precise genetic engineering which produces alterations to an organism's genome as small as a single base pair with no incidental or auxiliary modifications; this technique is crucial to the field of synthetic biology, which requires such precision in the installation of novel genetic circuits into host genomes. While a new methodology for most organisms, genome editing capabilities have been used in the budding yeast Saccharomyces cerevisiae for decades. In this review, I will present a brief history of genome editing in S. cerevisiae, discuss the current gold standard method of Cas9‐mediated genome editing, and speculate on future directions of the field.
Congenital rectovaginal fistula with anorectal agenesis
Authors: Tiwari Charu , Shah Hemanshi , Bothra Jyoti , Sandlas Gursev 
Published: December 2017

Background:
Rectovaginal fistula is a rare type of anorectal malformation; the incidence being less than 1%. We describe five cases of rectovaginal fistula managed at our institution.

Materials and methods:
Case records of five female neonates with rectovaginal fistula managed at our institute between 2010 and 2016 were reviewed and analysed with respect to age at presentation, clinical presentations, physical findings, investigations, management and outcome.

Results:
The age at presentation varied from 1 day to 2 years of age. Three of them presented in the neonatal period, one presented at 1 month of age and one at two years of age with sigmoid loop colostomy done elsewhere. All had absent anal opening; two neonates passed small amounts of stools through vagina, but little in amounts. The one-month old patient had history of passing stools through vaginal orifice, but had presented to us with obstruction. All patients underwent high sigmoid loop colostomy followed by definitive procedure at a later date – Posterior Sagittal Anorectoplasty. One patient is awaiting definitive repair.

Conclusion:
Rectovaginal fistula is a rare anorectal malformation and needs thorough investigation and appropriate management for good outcome.