bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of QT prolongation and torsade de pointes associated with exposure to hydroxyzine: re‐evaluation of an established drug
Authors: Schlit Anne‐Françoise , Delaunois Annie , Colomar Aurore , Claudio Branderley , Cariolato Luca , Boev Rossen , Valentin Jean‐Pierre , Peters Christopher , Sloan Victor S. , Bentz Jürgen W. G. 
Published: April 2017

AbstractSeveral noncardiac drugs have been linked to cardiac safety concerns, highlighting the importance of post‐marketing surveillance and continued evaluation of the benefit‐risk of long‐established drugs. Here, we examine the risk of QT prolongation and/or torsade de pointes (TdP) associated with the use of hydroxyzine, a first generation sedating antihistamine. We have used a combined methodological approach to re‐evaluate the cardiac safety profile of hydroxyzine, including: (1) a full review of the sponsor pharmacovigilance safety database to examine real‐world data on the risk of QT prolongation and/or TdP associated with hydroxyzine use and (2) nonclinical electrophysiological studies to examine concentration‐dependent effects of hydroxyzine on a range of human cardiac ion channels. Based on a review of pharmacovigilance data between 14th December 1955 and 1st August 2016, we identified 59 reports of QT prolongation and/or TdP potentially linked to hydroxyzine use. Aside from intentional overdose, all cases involved underlying medical conditions or concomitant medications that constituted at least 1 additional risk factor for such events. The combination of cardiovascular disorders plus concomitant treatment of drugs known to induce arrhythmia was identified as the greatest combined risk factor. Parallel patch‐clamp studies demonstrated hydroxyzine concentration‐dependent inhibition of several human cardiac ion channels, including the ether‐a‐go‐go‐related gene (hERG) potassium ion channels. Results from this analysis support the listing of hydroxyzine as a drug with “conditional risk of TdP” and are in line with recommendations to limit hydroxyzine use in patients with known underlying risk factors for QT prolongation and/or TdP.
Shear capacity prediction of steel plate shear walls with precompression from columns
Authors: Lv Yang , Li Zhong‐Xian , Lu Guoxing 
Published: April 2017

SummaryThis paper investigates the shear capacity of the unstiffened steel plate shear walls with gravity loads from the adjacent boundary columns that is produced during the construction process. The distribution and transferring of gravity loads between boundary columns and the infill steel plate are proposed. Then, the infill steel plate is partitioned into 3 zones bounded on the effective length, the inclination angle, and shear capacity of each zone that is proposed and discussed, and the shear capacity of the infill steel plate is summed over the 3 zones. Finally, based on the three specimens tested by Park et al. (2007), shear capacity prediction of 18 more numerical steel plate shear wall specimens with the axial stresses of the boundary columns equal to 50 MPa, 100 MPa, 150 MPa, 200 MPa, 250 MPa, and 300 MPa are analyzed.
Combined Preoperative Portal and Hepatic Vein Embolization (Biembolization) to Improve Liver Regeneration Before Major Liver Resection: A Preliminary Report
Authors: Le Roy Bertrand , Perrey Antoine , Fontarensky Mikael , Gagnière Johan , Abergel Armand , Pereira Bruno , Lambert Celine , Boyer Louis , Pezet Denis , Chabrot Pascal , Buc Emmanuel 
Published: April 2017

AbstractBackgroundInsufficient volume of the future liver remnant (FLR) is a major cause of non‐resectable disease in patients presenting with primary or metastatic liver tumours. The objective of this study was to evaluate the safety and efficacy of the combined preoperative portal and hepatic vein embolization (biembolization) before extended right liver resections.MethodsThis retrospective study was performed in a tertiary centre between 2014 and 2015. Combined right portal and hepatic vein embolization (biembolization) was proposed, as an alternative to ALPPS procedure, for all patients with primary or metastatic liver tumour, before right extended hepatectomy. CT scan liver volumetry was assessed before biembolization, three weeks after biembolization and one week after surgery.ResultsSeven patients underwent biembolization. All patients had right portal vein embolization (PVE) combined with right hepatic vein embolization (HVE, n = 4), median HVE (n = 2) and right + median HVE (n = 1). Three patients had preoperative liver disease and two received preoperative chemotherapy. No biembolization procedure‐related complications occurred. The mean FLR regeneration rate was 52.6% (range: 18.2–187.9) after the biembolization. One patient with gallbladder carcinoma was not operated because of peritoneal carcinomatosis diagnosed after the biembolization. The remnant six patients did not develop postoperative liver failure.ConclusionsBiembolization seems to induce safe, reproducible and effective FLR growth before extended right hepatectomy, in patients with primary or metastatic liver tumour.
Minimally Invasive Research Strategies in Huron-Wendat Archaeology
Authors: Glencross Bonnie , Warrick Gary , Eastaugh Edward , Hawkins Alicia , Hodgetts Lisa , Lesage Louis 
Published: April 2017

ABSTRACTThe rapid pace of economic, political, and social change over the past 150 years has framed and reframed archaeological practice in Ontario. Indigenous groups have become increasingly involved in and critical of archaeological research. Indigenous peoples who value archaeological investigation of ancestral sites, but also desire to protect their buried ancestors, have restricted archaeological excavation and the analysis of remains. Over the last decade, research and consulting archaeologists in Ontario, Canada, have worked collaboratively with Indigenous peoples with an eye to developing sustainable archaeology practices. In the spirit of sustainable archaeology, a comprehensive research project and field school run by Wilfrid Laurier University is training the next generation of archaeologists to adopt investigative techniques that minimize disturbance of ancestral sites. Here we present the results of our surface, magnetic susceptibility, and metal detecting surveys of a Huron-Wendat village site, which pose minimally invasive solutions for investigating village sites in wooded areas. The water-sieving of midden soils in an attempt to recover 100 percent of cultural materials, and the analysis of archived collections also honor the values of Indigenous descendant communities by limiting additional invasive excavation.
Beam halo study on the electron storage ring
Authors: Wang D. , Bambade P. , Naito T. , Yokoya K. , Gao J. 
Published: April 2017

AbstractHalo distribution is a key topic for background study. This paper has developed an analytical method to give an estimation of beam halo distribution in storage rings. This is a creative new theory. As an example, the equilibrium particle distribution of the beam tail in the Accelerator Test Facility damping ring is calculated analytically with different emittance and different vacuum degree. The analytical results agree the measurements very well. This is a general method, which can be applied to any electron rings.
The efficacy of primary care chaplaincy compared with antidepressants: a retrospective study comparing chaplaincy with antidepressants
Authors: Macdonald Gordon 
Published: April 2017

AimTo determine the effectiveness of primary care chaplaincy (PCC) when used as the sole intervention, with outcomes being compared directly with those of antidepressants. This was to be carried out in a homogenous study population reflective of certain demographics in the United Kingdom.BackgroundIncreasing numbers of patients are living with long-term conditions and ‘modern maladies’ and are experiencing loss of well-being and depression. There is an increasing move to utilise non-pharmacological interventions such as ‘talking therapies’ within this context. Chaplaincy is one such ‘talking therapy’ but within primary care its evidence base is sparse with only one quantitative study to date. There is therefore a need to evaluate PCC excluding those co-prescribed antidepressants, as this is not evidenced in the literature as yet. PCC also needs to be directly compared with the use of antidepressants to justify its use as a valid alternative treatment for loss of well-being and depression.MethodsThis was a retrospective observational study based on routinely collected data. There were 107 patients in the PCC group and 106 in the antidepressant group. Socio-demographic data were collected. Their pre- and post-intervention (either chaplaincy or antidepressant) well-being was assessed, by the Warwick-Edinburgh Mental Well-being Scale (WEMWBS) which is a validated Likert scale.FindingsThe majority of both groups were female with both groups showing marked ethnic homogeneity. PCC was associated with a significant and clinically meaningful improvement in well-being at a mean follow-up of 80 days. This treatment effect was maintained after those co-prescribed antidepressants were removed. PCC was associated with an improvement in well-being similar to that of antidepressants with no significant difference between the two groups.
Eigenvector Centrality is a Metric of Elastomer Modulus, Heterogeneity, and Damage
Authors: Welch P. M. , Welch C. F. 
Published: April 2017

AbstractWe present an application of eigenvector centrality to encode the connectivity of polymer networks resolved at the micro- and meso-scopic length scales. This method captures the relative importance of different nodes within the network structure and provides a route toward the development of a statistical mechanics model that correlates connectivity with mechanical response. This scheme may be informed by analytical and semi-analytical models for the network structure, or through direct experimental examination. It may be used to predict the reduction in mechanical performance for heterogeneous materials subjected to specific modes of damage. Here, we develop the method and demonstrate that it leads to the prediction of established trends in elastomers. We also apply the model to the case of a self-healing polymer network reported in the literature, extracting insight about the fraction of bonds broken and re-formed during strain and recovery.
Multi-functional Ultrasonic Micro-elastography Imaging System
Authors: Qian Xuejun , Ma Teng , Yu Mingyue , Chen Xiaoyang , Shung K. Kirk , Zhou Qifa 
Published: April 2017

AbstractIn clinical decision making, in addition to anatomical information, biomechanical properties of soft tissues may provide additional clues for disease diagnosis. Given the fact that most of diseases are originated from micron sized structures, an elastography imaging system of fine resolution (~100 µm) and deep penetration depth capable of providing both qualitative and quantitative measurements of biomechanical properties is desired. Here, we report a newly developed multi-functional ultrasonic micro-elastography imaging system in which acoustic radiation force impulse imaging (ARFI) and shear wave elasticity imaging (SWEI) are implemented. To accomplish this, the 4.5 MHz/40 MHz transducer were used as the excitation/detection source, respectively. The imaging system was tested with tissue-mimicking phantoms and an ex vivo chicken liver through 2D/3D imaging. The measured lateral/axial elastography resolution and field of view are 223.7 ± 20.1/109.8 ± 6.9 µm and 1.5 mm for ARFI, 543.6 ± 39.3/117.6 ± 8.7 µm and 2 mm for SWEI, respectively. These results demonstrate that the promising capability of this high resolution elastography imaging system for characterizing tissue biomechanical properties at microscale level and its translational potential into clinical practice.
Effectiveness of Immersive Videos in Inducing Awe: An Experimental Study
Authors: Chirico Alice , Cipresso Pietro , Yaden David B. , Biassoni Federica , Riva Giuseppe , Gaggioli Andrea 
Published: April 2017

AbstractAwe, a complex emotion composed by the appraisal components of vastness and need for accommodation, is a profound and often meaningful experience. Despite its importance, psychologists have only recently begun empirical study of awe. At the experimental level, a main issue concerns how to elicit high intensity awe experiences in the lab. To address this issue, Virtual Reality (VR) has been proposed as a potential solution. Here, we considered the highest realistic form of VR: immersive videos. 42 participants watched at immersive and normal 2D videos displaying an awe or a neutral content. After the experience, they rated their level of awe and sense of presence. Participants’ psychophysiological responses (BVP, SC, sEMG) were recorded during the whole video exposure. We hypothesized that the immersive video condition would increase the intensity of awe experienced compared to 2D screen videos. Results indicated that immersive videos significantly enhanced the self-reported intensity of awe as well as the sense of presence. Immersive videos displaying an awe content also led to higher parasympathetic activation. These findings indicate the advantages of using VR in the experimental study of awe, with methodological implications for the study of other emotions.
Contrasting response of rainfall extremes to increase in surface air and dewpoint temperatures at urban locations in India
Authors: Ali Haider , Mishra Vimal 
Published: April 2017

AbstractRainfall extremes are projected to increase under the warming climate. The Clausius-Clapeyron (C-C) relationship provides a physical basis to understand the sensitivity of rainfall extremes in response to warming, however, relationships between rainfall extremes and air temperature over tropical regions remain uncertain. Here, using station based observations and remotely sensed rainfall, we show that at a majority of urban locations, rainfall extremes show a negative scaling relationship against surface air temperature (SAT) in India. The negative relationship between rainfall extremes and SAT in India can be attributed to cooling (SAT) due to the monsoon season rain events in India, suggesting that SAT alone is not a good predictor of rainfall extremes in India. In contrast, a strong (higher than C-C rate) positive relationship between rainfall extremes and dew point (DPT) and tropospheric temperature (T850) is shown for most of the stations, which was previously unexplored. Subsequently, DPT and T850 were used as covariates for non-stationary daily design storms. Higher magnitude design storms were obtained under the assumption of a non-stationary climate. The contrasting relationship between rainfall extremes with SAT and DPT has implications for understanding the changes in rainfall extremes in India under the projected climate.
Heat shock protein70 is implicated in modulating NF-κB activation in alveolar macrophages of patients with active pulmonary tuberculosis
Authors: Wang Chun-Hua , Chou Pai-Chien , Chung Fu-Tsai , Lin Horng-Chyuan , Huang Kuo-Hsiung , Kuo Han-Pin 
Published: April 2017

AbstractHeat shock proteins (HSPs) have been shown to modulate NF-κB activation. It is unknown whether HSP70 plays a role in modulating NF-κB-mediated pro-inflammatory cytokines released from alveolar macrophage (AM) of patients with active pulmonary tuberculosis (TB). Peripheral blood monocytes (PBMs) and AM were sampled from nineteen active TB patients and 14 healthy individuals. HSP70 expression was 3-fold higher in AMs of active TB patients than normal subjects, and declined after receiving 3-month anti-TB treatment. Overexpression of HSP70 by transfection with HSP70 plasmid decreased p-IκBα and p65 NF-κB activities. Inhibition of NF-κB activation using NF-κB or MAPK inhibitors increased HSP70 expression in AM of TB patients. Blocking p38- or ERK-MAPK decreased NF-κB and IκB activities, leading to up-regulated HSP70 expression. Overexpression of HSP70 alone or with p38 or ERK inhibitors decreased TNF-α (57%, 83% and 74%, respectively) and IL-6 (53%, 70%, and 67%, respectively) release from macrophages of TB patients. In conclusion, HSP70 modulates NF-κB activation in AM of TB patients, through inhibiting IκB-α phosphorylation or acting as a chaperon molecule to prevent NF-κB binding to the target genes by facilitating degradation. The upregulated HSP70 may suppress the release of pro-inflammatory cytokines during active PTB infection, and prevent overwhelming tissue damage.
New Bicyclic Cembranoids from the South China Sea Soft Coral Sarcophyton trocheliophorum
Authors: Liang Lin-Fu , Chen Wen-Ting , Li Xu-Wen , Wang He-Yao , Guo Yue-Wei 
Published: April 2017

AbstractNine new bicyclic cembranoids, sarcophytrols M–U(1–9), were isolated from the South China Sea soft coral Sarcophyton trocheliophorum as minor components, along with one known related cembranoid 10. Their structures were elucidated by detailed spectroscopic analysis and chemical conversion. The chemical structures of these metabolites are characterized by the different patterns of the additional cyclization within the 14-member skeleton, which leading to the formation of furan, pyran, oxepane, and peroxyl rings, respectively. Among them, sarcophytrols R and S(6 and 7) share a rare decaryiol skeleton with an unusual C12/C15 cyclization. In addition, the absolute configurations of sarcophytrols M and T(1 and 8) were determined by the modified Mosher’s method. The research of these new secondary metabolites provided a further understanding of the diversity of cyclized cembranoids from the title species.
MicroRNA-26a targets MAPK6 to inhibit smooth muscle cell proliferation and vein graft neointimal hyperplasia
Authors: Tan Juanjuan , Yang Liguo , Liu Cuicui , Yan Zhiqiang 
Published: April 2017

AbstractNeointima formation is the major reason for vein graft failure. However, the underlying mechanism is unclear. The aim of this study was to determine the role of miR-26a in the development of neointimal hyperplasia of autogenous vein grafts. Using autologous jugular vein grafts in the rat carotid artery as a model, we found that miR-26a was significantly downregulated in grafted veins as well as proliferating vascular smooth muscle cells (VSMCs) stimulated with platelet-derived growth factor-BB (PDGF-BB). Overexpression of miR-26a reduced the proliferation and migration of VSMCs. Further analysis revealed that the effects of miR-26a in VSMCs were mediated by targeting MAPK6 at the mRNA and protein levels. Luciferase assays showed that miR-26a repressed wild type (WT) MAPK6-3′-UTR-luciferase activity but not mutant MAPK6-3′-UTR-luciferease reporter. MAPK6 deficiency reduced proliferation and migration; in contrast, overexpression of MAPK6 enhanced the proliferation and migration of VSMCs. This study confirmed that neointimal hyperplasia in vein grafts was reduced in vivo by up-regulated miR-26a expression. In conclusion, our results showed that miR-26a is an important regulator of VSMC functions and neointimal hyperplasia, suggesting that miR-26a may be a potential therapeutic target for autologous vein graft diseases.
Fabrication, characterization, and biological evaluation of anti-HER2 indocyanine green-doxorubicin-encapsulated PEG-b-PLGA copolymeric nanoparticles for targeted photochemotherapy of breast cancer cells
Authors: Lee Yu-Hsiang , Chang Da-Sheng 
Published: April 2017

AbstractIn this study, we aimed to develop anti-human epidermal growth factor receptor 2 (HER2) indocyanine green (ICG)-doxorubicin (DOX)-encapsulated polyethylene glycol-poly(lactic-co-glycolic acid) diblock copolymeric nanoparticles (HIDPPNPs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer, a highly aggressive and medicine-resistant breast carcinoma. The HIDPPNPs were fabricated using a solvent evaporation technique followed by carbodiimide-mediated antibody conjugation on the nanoparticle surface. Compared with freely dissolved ICG, the HIDPPNPs conferred enhanced thermal stability to the entrapped ICG, were able to generate a hyperthermia effect at concentrations ≥1 μM ICG equivalent and provided increased production of singlet oxygen under 808-nm laser irradiation with an intensity of 6 W/cm2. Furthermore, the uptake efficiency of the HIDPPNPs in MDA-MB-453/HER2(+) cells was approximately 2-fold higher than that in MCF7/HER2(−) cells, demonstrating that the HIDPPNPs specifically target HER2-expressing cells. Based on the viability analysis, the HIDPPNPs exhibited effective cytotoxicity upon light exposure (808 nm; 6 W/cm2), and the resulting cell death rate was even higher than that caused by using twice amount of encapsulated DOX or ICG alone. These results indicate that the developed HIDPPNPs may serve as a feasible tool for use in anti-HER2 breast cancer therapy with reduced chemotoxicity.
Imaging genetics approach to Parkinson’s disease and its correlation with clinical score
Authors: Kim Mansu , Kim Jonghoon , Lee Seung-Hak , Park Hyunjin 
Published: April 2017

AbstractParkinson’s disease (PD) is a progressive neurodegenerative disorder associated with both underlying genetic factors and neuroimaging findings. Existing neuroimaging studies related to the genome in PD have mostly focused on certain candidate genes. The aim of our study was to construct a linear regression model using both genetic and neuroimaging features to better predict clinical scores compared to conventional approaches. We obtained neuroimaging and DNA genotyping data from a research database. Connectivity analysis was applied to identify neuroimaging features that could differentiate between healthy control (HC) and PD groups. A joint analysis of genetic and imaging information known as imaging genetics was applied to investigate genetic variants. We then compared the utility of combining different genetic variants and neuroimaging features for predicting the Movement Disorder Society-sponsored unified Parkinson’s disease rating scale (MDS-UPDRS) in a regression framework. The associative cortex, motor cortex, thalamus, and pallidum showed significantly different connectivity between the HC and PD groups. Imaging genetics analysis identified PARK2, PARK7, HtrA2, GIGYRF2, and SNCA as genetic variants that are significantly associated with imaging phenotypes. A linear regression model combining genetic and neuroimaging features predicted the MDS-UPDRS with lower error and higher correlation with the actual MDS-UPDRS compared to other models using only genetic or neuroimaging information alone.
Treatment of Posttubercular Syringomyelia Not Responsive to Antitubercular Therapy: Case Report and Review of Literature
Authors: Canova Giuseppe , Boaro Alessandro , Giordan Enrico , Longatti Pierluigi 
Published: April 2017

AbstractPosttubercular adhesive arachnoiditis is a rare, late complication of tubercular meningitis. Syringomyelia can develop as a consequence of intramedullary cystic lesions and cerebrospinal fluid (CSF) flow disturbance around the spinal cord, even after successful chemotherapy. We reviewed the literature related to posttubercular syringomyelia treatment and suggest a new combined surgical approach. A 25-year-old Nigerian male patient presented with legs numbness, urinary disturbance, and legs weakness. Spinal magnetic resonance revealed a T5-T7 syringomyelia, secondary to adhesive spinal arachnoiditis related to a history of tuberculous meningitis. Adhesiolysis by direct visualization with a flexible endoscope was performed and a handmade S-italic syringe-subdural shunt was placed to restore CSF flow. During the postoperative course, the neurological deficits improved together with the resolution of the syrinx. Long-term magnetic resonance imaging follow-up documented no recurrences or shunt displacements. We suggest that, when antitubercular therapy is not effective to resolve postarachnoiditis syrinx, arachnolysis with a flexible endoscope together with the placement of an S-italic shunt allowed free CSF communication between the syrinx and the subarachnoid space. Furthermore, we support that the use of an s-shaped shunt could prevent displacement or migration of the device and allows an easier revision in case of acute or late complications.