bluuebunny/crossref_metadata_2025_split huggingface dataset:
Copper‐Catalyzed Tandem Amide N‐Arylation and Regioselective Cyclization of 2‐Alkynylbenzamides
Authors: Minami Hideki , Sueda Takuya , Okamoto Noriko , Miwa Yoshihisa , Ishikura Minoru , Yanada Reiko 
Published: December 2015

AbstractA new approach to form iminoisocoumarins from readily available and stable 2‐alkynylbenzamides was developed by using a tandem copper‐catalyzed N‐arylation and regioselective 6‐endo‐dig cyclization in the presence of diaryliodonium salts, a copper catalyst, and 2,6‐di‐tert‐butylpyridine. The arylation occurred at the nitrogen atom rather than the oxygen atom of the amide group, the alkynyl carbon, or the benzene ring of the benzamide. Cyclization occurred through a preferential nucleophilic attack by the oxygen rather than the nitrogen atom of the amide group to produce iminoisocoumarin derivatives in good to moderate yields.
A Simple Heterogeneous Catalyst for Phosphite Addition on Carbonyl Groups
Authors: Santacroce Veronica , Paris Emanuele , Cauzzi Daniele , Maggi Raimondo , Maestri Giovanni 
Published: December 2015

AbstractA cheap and easily recoverable heterogeneous catalyst could efficiently trigger C–P bond formation by selective addition of phosphites to the carbonyl group of aldehydes and ketones. The reactions afford the desired products in good to excellent yields and do not require the presence of a solvent. Furthermore, nearly stoichiometric amounts of reagents could be used as the hydrotalcite catalyst does not cause the condensation of the carbonyl derivatives, even when aliphatic aldehydes are employed.
The Role of Non‐suicidal Self‐Injury and Binge‐Eating/Purging Behaviours in the Caregiving Experience Among Mothers and Fathers of Adolescents with Eating Disorders
Authors: Depestele Lies , Lemmens Gilbert M. D. , Dierckx Eva , Baetens Imke , Schoevaerts Katrien , Claes Laurence 
Published: December 2015

AbstractThis study investigated the caregiving experiences of mothers and fathers of restrictive and binge‐eating/purging eating disordered (ED) inpatients with and without non‐suicidal self‐injury (NSSI). Sixty‐five mothers and 65 fathers completed the Experience of Caregiving Inventory. All inpatients completed the Self‐Injury Questionnaire—Treatment Related to assess NSSI and the Eating Disorder Evaluation Scale to assess eating disorder symptoms. Mothers reported significant more negative and more positive caregiving experiences compared with fathers. Mothers (but not fathers) of restrictive ED patients reported more positive caregiving experiences compared with mothers of binge‐eating/purging patients. The presence of NSSI in ED patients was associated with more negative caregiving experiences of both parents. Mothers and fathers of ED inpatients differ in caregiving experiences, and both binge‐eating behaviours and NSSI negatively affect their caregiving experience. Therefore, supportive interventions for parents of ED patients are necessary, especially of those patients who engage in NSSI. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association.
The Effect of Maltreatment Type on Adolescent Executive Functioning and Inner Speech
Authors: Kirke‐Smith Mimi , Henry Lucy A. , Messer David 
Published: December 2015

There are indications that different types of maltreatment can lead to different cognitive and behavioural outcomes. This study investigated whether maltreatment type was related to executive functioning (EF) abilities and the use of inner speech. Forty maltreated adolescents and a comparison group of 40 non‐maltreated typically developing adolescents completed a battery of tasks designed to assess both their EF abilities and their vulnerability to disruptions to inner speech. They also completed an IQ test. Multivariate analysis of covariance (MANCOVA) and ANCOVA analyses were carried out to examine potential effects of maltreatment type (abuse alone; neglect alone; abuse/neglect combined and no maltreatment) on EF and use of inner speech.Maltreatment type was related to EF abilities. In particular, abuse only and abuse/neglect combined had a greater negative impact on EF than neglect only. However, the neglect alone group was more vulnerable to disruptions to inner speech than the other two maltreatment groups, suggesting that they may be more reliant on the use of inner speech. These findings provide new insights into the differential impact of maltreatment type on EF and the use of inner speech in adolescence and could be used to improve the educational outcomes of these vulnerable young people. Copyright © 2015 John Wiley & Sons, Ltd.
Placenta Mesenchymal Stem Cell Derived Exosomes Confer Plasticity on Fibroblasts
Authors: Tooi Masayuki , Komaki Motohiro , Morioka Chikako , Honda Izumi , Iwasaki Kengo , Yokoyama Naoki , Ayame Hirohito , Izumi Yuichi , Morita Ikuo 
Published: December 2015

ABSTRACTMesenchymal stem cell (MSC)‐conditioned medium (MSC‐CM) has been reported to enhance wound healing. Exosomes contain nucleic acids, proteins, and lipids, and function as an intercellular communication vehicle for mediating some paracrine effects. However, the function of MSC‐derived exosomes (MSC‐exo) remains elusive. In this study, we isolated human placenta MSC (PlaMSC)‐derived exosomes (PlaMSC‐exo) and examined their function in vitro. PlaMSCs were isolated from human term placenta using enzymatic digestion. PlaMSC‐exo were prepared from the conditioned medium of PlaMSC (PlaMSC‐CM) by ultracentrifugation. The expression of stemness‐related genes, such as OCT4 and NANOG, in normal adult human dermal fibroblasts (NHDF) after incubation with PlaMSC‐exo was measured by real‐time reverse transcriptase PCR analysis (real‐time PCR). The effect of PlaMSC‐exo on OCT4 transcription activity was assessed using Oct4‐EGFP reporter mice‐derived dermal fibroblasts. The stimulating effects of PlaMSC‐exo on osteoblastic and adipocyte‐differentiation of NHDF were evaluated by alkaline phosphatase (ALP), and Alizarin red S‐ and oil red O‐staining, respectively. The expression of osteoblast‐ and adipocyte‐related genes was also assessed by real‐time PCR. The treatment of NHDF with PlaMSC‐exo significantly upregulated OCT4 and NANOG mRNA expression. PlaMSC‐exo also enhanced OCT4 transcription. The NHDF treated with PlaMSC‐exo exhibited osteoblastic and adipocyte‐differentiation in osteogenic and adipogenic induction media. PlaMSC‐exo increase the expression of OCT4 and NANOG mRNA in fibroblasts. As a result, PlaMSC‐exo influence the differentiation competence of fibroblasts to both osteoblastic and adipocyte‐differentiation. It shows a new feature of MSCs and the possibility of clinical application of MSC‐exo. J. Cell. Biochem. 117: 1658–1670, 2016. © 2015 Wiley Periodicals, Inc.
Histomorphological changes in testes of broad‐snouted caimans (Caiman latirostris) associated with in ovo exposure to endocrine‐disrupting chemicals
Authors: Durando Milena , Canesini Guillermina , Cocito Laura L. , Galoppo Germán H. , Zayas Marcelo A. , Luque Enrique H. , Muñoz‐de‐Toro Mónica 
Published: December 2015

ABSTRACTStudies regarding the effects of endocrine‐disrupting chemicals (EDCs) on the reproductive functions of wild animals have raised increasing concern. Thus, here we evaluated the consequences of in ovo exposure to endosulfan (END) and bisphenol A (BPA) in testes from neonatal to juvenile (Juv) caimans (Caiman latirostris). Caiman eggs were collected from areas with low to moderate anthropogenic intervention and incubated at male‐producing temperature. At stage 20 of embryonic development (previous to gonad sex determination), eggs were exposed to either END (20 ppm) or BPA (1.4 ppm) and male gonad histomorphology examined in 10‐day‐old, 90‐day‐old, and Juv caimans. The relative seminiferous tubular area (RTA) was measured in testes and the proliferation index and the expression of estrogen receptor alpha (ERα) were quantified in intratubular cells. Regardless of the treatment, all eggs resulted in male hatchlings. The testes of EDC‐exposed caimans presented tortuous seminiferous tubules with empty tubular lumens. The RTA of 10‐day‐old caimans exposed to BPA was decreased. The percentage of cells expressing ERα was not different after in ovo treatment with EDCs (compared to the Control group), although caimans exposed to END showed a different ERα distribution pattern. The proliferation index was lower in 90‐day‐old caimans exposed to END, and higher in Juv caimans exposed to BPA. In ovo exposure to END or BPA modified sensitive parameters of C. latirostris male gonads. The alterations described here might compromise not only the sexual maturation but also the reproductive performance of adult caimans. J. Exp. Zool. 325A:84–96, 2016. © 2015 Wiley Periodicals, Inc.
Automated design of bandpass filters based on open complementary split ring resonators (OCSRRs) using aggressive space mapping (ASM) optimization
Authors: Rodríguez Ana , Selga Jordi , Sans Marc , Martín Ferran , Boria Vicente 
Published: December 2015

AbstractThis paper is focused on the design of bandpass filters based on open complementary split ring resonators (OCSRRs) in microstrip technology. The filters are obtained by coupling the corresponding shunt resonators (OCSRRs) through admittance inverters (quarter wavelength transmission line sections). Different undesirable effects derived from the chosen topology are taken into account and are compensated at the design level. These effects include the reduction in bandwidth (caused by the narrowband functionality of the line sections acting as admittance inverters), and the presence of a spurious band above the filter passband. The proposed technique is based on the well‐known aggressive space mapping algorithm, which is a powerful tool for the synthesis and design of microwave components. The design of the OCSRR‐based filter is provided in a fully automated way as the main result of this paper. Copyright © 2015 John Wiley & Sons, Ltd.
The place and role of (moral) anger in organizational behavior studies
Authors: Lindebaum Dirk , Geddes Deanna 
Published: December 2015

SummaryThe aim of this article is to conceptually delineate moral anger from other related constructs. Drawing upon social functional accounts of anger, we contend that distilling the finer nuances of morally motivated anger and its expression can increase the precision with which we examine prosocial forms of anger (e.g., redressing injustice), in general, and moral anger, in particular. Without this differentiation, we assert that (i) moral anger remains theoretically elusive, (ii) that this thwarts our ability to methodologically capture the unique variance moral anger can explain in important work outcomes, and that (iii) this can promote ill‐informed organizational policies and practice. We offer a four‐factor definition of moral anger and demonstrate the utility of this characterization as a distinct construct with application for workplace phenomena such as, but not limited to, whistle‐blowing. Next, we outline a future research agenda, including how to operationalize the construct and address issues of construct, discriminant, and convergent validity. Finally, we argue for greater appreciation of anger's prosocial functions and concomitant understanding that many anger displays can be justified andlackharmful intent. If allowed and addressed with interest and concern, these emotional displays can lead to improved organizational practice. © 2015 The Authors Journal of Organizational Behavior Published by John Wiley & Sons Ltd.
Poly(methyl methacrylate)/Graphene Microparticles Having a Core/Shell Structure Prepared with Carboxylated Graphene as a Pickering Stabilizer
Authors: Erdenedelger Gansukh , Dao Trung Dung , Jeong Han Mo 
Published: December 2015

Two kinds of carboxylated thermally reduced graphenes (carboxylated TRGs) with different lateral sizes are examined as a Pickering stabilizer in the suspension polymerization of methyl methacrylate. The size and the shape of the prepared composite particles are irregular due to agglomeration, more evidently when the larger carboxylated TRG is used. In addition, carboxylated TRG is distributed not only on the surface but also inside the composite particles. It indicates that the carboxylated TRG alone is not a stable Pickering agent. However, a very small dosage of acrylic acid remedies all these issues because acrylic acid interacts with carboxylated TRG and synergizes the stabilizing effect. The compression molded composite of the core/shell poly(methyl methacrylate)/carboxylated TRG particles exhibits a very low percolation threshold of electrical conductivity of 0.03 vol%. It demonstrates that the carboxylated TRG shells of the composite particles effectively form a segregated conductive network throughout the composite.
image
The relative contributions of function, perceived psychological burden and partner support to cognitive distress in bladder cancer
Authors: Heyes Susan M. , Bond Malcolm J. , Harrington Ann , Belan Ingrid 
Published: December 2015

AbstractObjectiveBladder cancer is a genitourinary disease of increasing incidence. Despite improvements in treatment, outcomes remain equivocal with high recurrence rates. It is associated with poor psychosocial outcomes due to reduced functioning of the genitourinary system. The objective of these analyses was to query whether reported loss of function or the perception of psychological burden caused by this functional impedance was the key to understanding psychosocial outcomes.MethodsThe sample comprised 119 participants with a confirmed diagnosis of bladder cancer. They completed a self‐report questionnaire comprising the Bladder Cancer Index, Mini‐mental Adjustment to Cancer Scale, Psychosocial Adjustment to Illness Scale and standard sociodemographic details. Simple mediation and serial mediation were used to explore the potential for psychological burden to mediate associations between loss of function and cognitive distress, and the potential additional contribution of positive partner support on these relationships. Age and duration of cancer were considered as covariates.ResultsSimple mediation demonstrated that the association between function and cognitive distress was fully mediated by perceived psychological burden. Serial mediation, which allowed for the addition of partner support, again demonstrated full mediation, with partner support being the key predictive variable.ConclusionsThese analyses emphasise the importance of an appreciation of individuals' interpretation of the burden occasioned by bladder cancer and the role of a supportive partner. The implications for management discussions and support services in alleviating negative psychological outcomes in bladder cancer are highlighted. Copyright © 2015 John Wiley & Sons, Ltd.
Nanostructured clathrates and clathrate‐based nanocomposites
Authors: Christian R. , Ikeda M. , Lientschnig G. , Prochaska L. , Prokofiev A. , Tomeš P. , Yan X. , Zolriasatein A. , Bernardi J. , Schachinger T. , Schwarz S. , Steiger‐Thirsfeld A. , Rogl P. , Populoh S. , Weidenkaff A. , Paschen S. 
Published: December 2015

AbstractIntermetallic clathrates are candidate materials for thermoelectric applications above room temperature. Here, we explore whether their intrinsically low lattice thermal conductivities can be further reduced by nanostructuring and whether this can further enhance their thermoelectric performance. As bulk nanostructuring routes we studied melt spinning and ball milling. To optimize the compaction process and/or stabilize the nanostructure we varied the process parameters, used additives, and studied clathrate‐based composites. Initial results on clathate nanowires as simpler model nanostructures are also presented.
Rapid profiling of antimicrobial compounds characterising B. subtilis TR50 cell‐free filtrate by high‐performance liquid chromatography coupled to high‐resolution Orbitrap™ mass spectrometry
Authors: Monaci Linda , Quintieri Laura , Caputo Leonardo , Visconti Angelo , Baruzzi Federico 
Published: December 2015

RationaleSeveral Bacillus strains, typically isolated from different food sources, represent renowned producers of a multitude of low and high molecular weight compounds, including lipopeptides and macrolactones, with an importance for their antimicrobial activity. The high homology shared by many of these compounds also occurring as closely related isoforms poses a challenge in their prompt detection.MethodsIdentification and structural elucidation is generally achieved by matrix‐assisted laser desorption/ionization (MALDI) or liquid chromatography (LC) coupled to mass spectrometry (MS) after a pre‐fractionation and/or purification step of the extract. In this paper we report the application of a method based on LC separation and high‐resolution Orbitrap™‐based MS for the rapid screening of raw filtrate of the strain Bacillus subtilis TR50 endowed with antimicrobial activity, without requiring any sample pre‐treatment.ResultsUpon direct analysis of the cell‐free filtrate of Bacillus subtilis TR50 by high‐resolution mass spectrometry (HRMS), different compounds families, that proved to exert a remarked antimicrobial activity against several foodborne pathogens, can be readily displayed along the chromatographic run. Among them, three different classes were identified and characterized belonging to the iturin, fengycin and surfactin groups. The high resolving power and accurate mass accuracy provided by the HRMS system in use ensured an enhanced selectivity compared to other mass spectrometers. In addition, after activation of the HCD cell, the HR‐MS/MS spectra can provide insights in the structural elucidation of several compounds.ConclusionsThe acquisition of HRMS spectra of raw filtrates of subtilis strains allows untargeted analysis of the major classes of compounds produced to be performed, thus facilitating identification of other unknown bioactive molecules after retrospective analysis. These features make this approach a fast tool applicable to the rapid screening and further identification of antimicrobial compounds released by Bacillus strains in raw filtrates. Copyright © 2015 John Wiley & Sons, Ltd.
Structures of polymeric pigments in red wine and their derived quantification markers revealed by high‐resolution quadrupole time‐of‐flight mass spectrometry
Authors: Zeng Liming , Teissèdre Pierre‐Louis , Jourdes Michaël 
Published: December 2015

RationaleThe quantification of polymeric pigment families in red wine through their derived quantification markers released during phloroglucinolysis will allow the understanding of their formation kinetics and evolutions during aging which has not been achieved until now and is in urgent need. The identification of these quantification markers was achieved by high‐resolution mass spectrometry (HRMS) in this study.MethodsHRMS was used to clarify the fragmentation patterns in positive mode of polymeric pigments and identify their derived quantification markers released during phloroglucinolysis.ResultsWith HRMS, identification of (epi)catechin‐malvidin‐3‐O‐glucoside adducts was simplified to MS/MS, and the fragmentation pattern of malvidin‐3‐O‐glucoside‐(epi)catechin adducts was clearly demonstrated. The attribution of four detected ions at m/z 1071.2765 in red wine to the trimeric structure of (epi)catechin‐[malvidin‐3‐O‐glucoside‐A type linkage‐(epi)catechin] and [malvidin‐3‐O‐glucoside‐A type linkage‐(epi)catechin]‐(epi)catechin was achieved for the first time by MS/MS and evidence given by phloroglucinolysis. Moreover, four kinds of derived quantification markers released from polymeric pigments during phloroglucinolysis were also identified.ConclusionsThe fragmentation pathways of polymeric pigments in red wine and their derived quantification markers released during acidic chemical depolymerisation were clarified which will allow their quantification in red wine. Copyright © 2015 John Wiley & Sons, Ltd.
Apparent activation of H2O and elimination of H2 from gas‐phase mixed‐metal complexes containing silver, calcium and deprotonated glycine
Authors: Osburn Sandra , Plaviak Alexandra , Pestok Jordan , Van Stipdonk Michael J. 
Published: December 2015

RationaleIon trap mass spectrometry was used to study the reactivity of species derived from gas‐phase, mixed‐metal complexes, [Ag2Xx(Gly‐H)3]+, where Xx = Ca, Mg, Sr and Ag, and in particular the apparent activation of an H2O ligand added during an ion‐molecule reaction.MethodsPrecursor [Ag2Xx(Gly‐H)3]+ complexes were formed by electrospray ionization (ESI) using spray solutions in which AgNO3, XxNO3 and glycine were mixed in a 1:1:3 molar ratio. Specific species for study of ion‐molecule reactions were created in a “top down” fashion using collision‐induced dissociation (CID). Ion‐molecule reactions were performed by selective isolation and storage in a linear ion trap, where reactions with adventitious H2O can occur.ResultsMultiple stages of CID of [Ag2Ca(Gly‐H)3]+ resulted in the formation of [AgHCa(Gly‐H)]+. An ion‐molecule reaction of this ion produced a peak 16 mass units higher which is hypothesized to be a result of addition of H2O followed by loss of H2. This reaction was studied further by replacing Ca with Mg, Sr and Ag; as well as by incorporating deuterium‐labelled glycine into the complex.ConclusionsThe experimental results showed the following pattern for the apparent rates of reaction: Mg > Sr > Ca. When silver is the only metal present there is an addition of water but no loss of H2. DFT and MP2 calculations help identify plausible pathways for decomposition of H2O and formation of H2. Copyright © 2015 John Wiley & Sons, Ltd.
A comparison of freeze‐drying and oven‐drying preparation methods for bulk and compound‐specific carbon stable isotope analyses: examples using the benthic macroinvertebrates Stenopsyche marmorata and Epeorus latifolium
Authors: Akamatsu Fumikazu , Suzuki Yaeko , Kato Yoshikazu , Yoshimizu Chikage , Tayasu Ichiro 
Published: December 2015

RationaleCarbon stable isotope analysis of bulk samples and fatty acids is an established method for tracing carbon flow pathways and reconstructing trophic interactions, but there is no consensus on which sample drying method should be used for sample preparation. The aim of this study was to determine if freeze‐drying and oven‐drying treatments used to prepare samples of the benthic macroinvertebrates Stenopsyche marmorata and Epeorus latifolium for bulk and fatty‐acid‐specific carbon stable isotope analysis yield different isotopic ratio values.MethodsFive individuals each from two species were split in half; one half was freeze‐dried and the other half was oven‐dried. The samples were ground and the δ13C values of the bulk samples and eight fatty acids were measured following combustion using an isotope ratio mass spectrometer coupled to an elemental analyzer or gas chromatography system.ResultsThe mean difference in the bulk and fatty acid δ13C values between freeze‐dried and oven‐dried samples was small (≤0.1‰ in both cases), although relatively large variations were observed in individual fatty‐acid‐specific δ13C values (maximum of ≤0.9 ‰). There were no significant differences in either bulk sample or fatty‐acid‐specific δ13C values between freeze‐dried or oven‐dried samples of the same species.ConclusionsFreeze‐drying and oven‐drying are equally acceptable methods for preparing freshly caught S. marmorata and E. latifolium samples for bulk and fatty‐acid‐specific carbon stable isotope analyses. Copyright © 2015 John Wiley & Sons, Ltd.