bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economy and fashion: analysing the use of simulated leather upholstery in a nineteenth century Australian coach
Authors: Ison Natalie , Wain Alison , Hoogewerff Jurian 
Published: February 2017

Abstract
The Ranken coach is a landau style horse-drawn vehicle brought to the Australian colony of New South Wales in the 1820s, and now held in the National Historical Collection of the National Museum of Australia. At some point, or points, in the vehicle’s history the roof structure has been altered and parts of its original interior and exterior upholstery have been replaced with black coated fabrics resembling imitation leather. Three data sources were brought together to support the hypothesis that the alterations to the coach were made between 1923 and 1938. Two of these sources were historical research on the vehicle and research on materials used to simulate leather in the times when the coach was likely to have been altered. These were used to determine the likely dates for these changes, as well as the types of materials available at the time. The third source involved physical means of investigation to study the chemical composition of the coatings. These included visual inspection, Ultraviolet fluorescence evaluation, solubility tests, the diphenylamine spot test, Fourier transform infrared spectroscopy, and pyrolysis gas chromatography, mass spectroscopy. The hypothesis formed was that the fabric used for the new interior upholstery was probably coated with an alkyd-based formulation, and that the fabric used for the new roof coating was probably coated with a cellulose nitrate based formulation. One of the key findings of this research was that the composition of the alkyd-based material does not exactly mirror modern formulations. This could be due to age-related deterioration, to the lack of standardisation in early formulations, or the fact that at the period in question, it appears to have been common to mix concoctions at the point of application. The physical analyses also supported hints in the historical documentation that topical “varnishes” may have been applied separately over the coated fabrics to improve their appearance and weatherproofing.
Optimal selection of operating parameters in end milling of Al-6061 work materials using multi-objective approach
Authors: Shaik Jakeer Hussain , J Srinivas 
Published: February 2017

Abstract
Background
Machining using vertical CNC end mill is popular in the modern material removal industries because of its ability to remove the material at a fast rate with a reasonably good surface quality.

Methods
In this work, the influence of important common machining process variables like feed, cutting speed and axial depth of cut on the output parameters such as surface roughness and amplitude of tool vibration levels in Al-6061 workpieces has been studied. With the use of experimental result analysis and mathematical modelling, correlations between the cutting process conditions and process outputs are studied in detail. The cutting experiments are planned with response surface methodology (RSM) using Box-Behnken design (BBD).

Results
This work proposes a multi-objective optimization approach based on genetic algorithms using experimental data so as to simultaneously minimize the tool vibration amplitudes and work-piece surface roughness. The optimum combination of process variable is further verified by the radial basis neural network model.

Conclusions
Finally, based on the multi-objective optimization approach and neural network models an interactive platform is developed to obtain the correct combination of process parameters.
Perforator-based flaps for the treatment of burn scar contractures: a review
Authors: Stekelenburg C. M. , Marck R. E. , Verhaegen P. D. H. M. , Marck K. W. , van Zuijlen P. P. M. 
Published: February 2017

Abstract
Patients with burn scars often experience functional problems because of scar contractures. Surgical treatment may be indicated for those burn scar contractures. If the contractures are small and linear, the contraction bands can be treated with local transposition flaps like the Z-plasty. Broader, diffuse contractures are more challenging and require a different surgical approach, such as the use of local tissue. The use of perforator-based flaps is promising; however, their true clinical significance for this type of burn reconstructions still needs to be determined. Therefore, we performed a review to evaluate the role of perforator-based flaps for burn scar contracture treatment. Electronic databases were searched using a predefined search strategy. Studies evaluating the long-term outcome of perforator-based flaps for the treatment of burn scar contractures were included. The methodological quality was tested and data was summarized. Five hundred and ten papers were identified of which eleven met the inclusion criteria. One study was a randomized controlled trial; ten were cohort studies of a pre-postoperative design. The papers described outcomes of free flaps and local flaps. Most studies had methodological shortcomings and used inappropriate statistical methods. Perforator-based interposition flaps appear to be highly relevant for burn scar contracture treatment. However, due to the paucity and low quality of the studies that were assessed, no definitive conclusions about the true clinical significance could be reached. And therefore, only recommendations could be given for improvement of the quality of further primary research on the effectiveness of perforator-based flaps for burn scar contracture release.
Evidence of Stage Shift in Women Diagnosed With Ovarian Cancer During Phase II of the United Kingdom Familial Ovarian Cancer Screening Study
Authors: Rosenthal Adam N. , Fraser Lindsay S.M. , Philpott Susan , Manchanda Ranjit , Burnell Matthew , Badman Philip , Hadwin Richard , Rizzuto Ivana , Benjamin Elizabeth , Singh Naveena , Evans D. Gareth , Eccles Diana M. , Ryan Andy , Liston Robert , Dawnay Anne , Ford Jeremy , Gunu Richard , Mackay James , Skates Steven J. , Menon Usha , Jacobs Ian J. ,   on behalf of the United Kingdom Familial Ovarian Cancer Screening Study collaborators
Published: February 2017

Purpose To establish the performance of screening with serum cancer antigen 125 (CA-125), interpreted using the risk of ovarian cancer algorithm (ROCA), and transvaginal sonography (TVS) for women at high risk of ovarian cancer (OC) or fallopian tube cancer (FTC). Patients and Methods Women whose estimated lifetime risk of OC/FTC was ≥ 10% were recruited at 42 centers in the United Kingdom and underwent ROCA screening every 4 months. TVS occurred annually if ROCA results were normal or within 2 months of an abnormal ROCA result. Risk-reducing salpingo-oophorectomy (RRSO) was encouraged throughout the study. Participants were observed via cancer registries, questionnaires, and notification by centers. Performance was calculated after censoring 365 days after prior screen, with modeling of occult cancers detected at RRSO. Results Between June 14, 2007, and May 15, 2012, 4,348 women underwent 13,728 women-years of screening. The median follow-up time was 4.8 years. Nineteen patients were diagnosed with invasive OC/FTC within 1 year of prior screening (13 diagnoses were screen-detected and six were occult at RRSO). No symptomatic interval cancers occurred. Ten (52.6%) of the total 19 diagnoses were stage I to II OC/FTC (CI, 28.9% to 75.6%). Of the 13 screen-detected cancers, five (38.5%) were stage I to II (CI, 13.9% to 68.4%). Of the six occult cancers, five (83.3%) were stage I to II (CI, 35.9% to 99.6%). Modeled sensitivity, positive predictive value, and negative predictive value for OC/FTC detection within 1 year were 94.7% (CI, 74.0% to 99.9%), 10.8% (6.5% to 16.5%), and 100% (CI, 100% to 100%), respectively. Seven (36.8%) of the 19 cancers diagnosed < 1 year after prior screen were stage IIIb to IV (CI, 16.3% to 61.6%) compared with 17 (94.4%) of 18 cancers diagnosed > 1 year after screening ended (CI, 72.7% to 99.9%; P < .001). Eighteen (94.8%) of 19 cancers diagnosed < 1 year after prior screen had zero residual disease (with lower surgical complexity, P = .16) (CI, 74.0% to 99.9%) compared with 13 (72.2%) of 18 cancers subsequently diagnosed (CI, 46.5% to 90.3%; P = .09). Conclusion ROCA-based screening is an option for women at high risk of OC/FTC who defer or decline RRSO, given its high sensitivity and significant stage shift. However, it remains unknown whether this strategy would improve survival in screened high-risk women.
Multi-Institutional Assessment of Adverse Health Outcomes Among North American Testicular Cancer Survivors After Modern Cisplatin-Based Chemotherapy
Authors: Fung Chunkit , Sesso Howard D. , Williams Annalynn M. , Kerns Sarah L. , Monahan Patrick , Abu Zaid Mohammad , Feldman Darren R. , Hamilton Robert J. , Vaughn David J. , Beard Clair J. , Kollmannsberger Christian K. , Cook Ryan , Althouse Sandra , Ardeshir-Rouhani-Fard Shirin , Lipshultz Steve E. , Einhorn Lawrence H. , Fossa Sophie D. , Travis Lois B. ,   for the Platinum Study Group
Published: February 2017

PurposeTo provide new information on adverse health outcomes (AHOs) in testicular cancer survivors (TCSs) after four cycles of etoposide and cisplatin (EPX4) or three or four cycles of bleomycin, etoposide, cisplatin (BEPX3/BEPX4).MethodsNine hundred fifty-two TCSs > 1 year postchemotherapy underwent physical examination and completed a questionnaire. Multinomial logistic regression estimated AHOs odds ratios (ORs) in relation to age, cumulative cisplatin and/or bleomycin dose, time since chemotherapy, sociodemographic factors, and health behaviors.ResultsMedian age at evaluation was 37 years; median time since chemotherapy was 4.3 years. Chemotherapy consisted largely of BEPX3 (38.2%), EPX4 (30.9%), and BEPX4 (17.9%). None, one to two, three to four, or five or more AHOs were reported by 20.4%, 42.0%, 25.1%, and 12.5% of TCSs, respectively. Median number after EPX4 or BEPX3 was two (range, zero to nine and zero to 11, respectively; P > .05) and two (range, zero to 10) after BEPX4. When comparing individual AHOs for EPX4 versus BEPX3, Raynaud phenomenon (11.6% v 21.4%; P < .01), peripheral neuropathy (29.2% v 21.4%; P = .02), and obesity (25.5% v 33.0%; P = .04) differed. Larger cumulative bleomycin doses (OR, 1.44 per 90,000 IU) were significantly associated with five or more AHOs. Increasing age was a significant risk factor for one to two, three to four, or five or more AHOs versus zero AHOs (OR, 1.22, 1.50, and 1.87 per 5 years, respectively; P < .01); vigorous physical activity was protective (OR, 0.62, 0.51, and 0.41, respectively; P < .05). Significant risk factors for three to four and five or more AHOs included current (OR, 3.05 and 3.73) or former (OR, 1.61 and 1.76) smoking ( P < .05). Self-reported health was excellent/very good in 59.9% of TCSs but decreased as AHOs increased ( P < .001).ConclusionNumbers of AHOs after EPX4 or BEPX3 appear similar, with median follow-up of 4.3 years. A healthy lifestyle was associated with reduced number of AHOs.
Phase I Trial of the Human Double Minute 2 Inhibitor MK-8242 in Patients With Advanced Solid Tumors
Authors: Wagner Andrew J. , Banerji Udai , Mahipal Amit , Somaiah Neeta , Hirsch Heather , Fancourt Craig , Johnson-Levonas Amy O. , Lam Raymond , Meister Amy K. , Russo Giuseppe , Knox Clayton D. , Rose Shelonitda , Hong David S. 
Published: February 2017

PurposeTo evaluate MK-8242 in patients with wild-type TP53 advanced solid tumors.Patients and MethodsMK-8242 was administered orally twice a day on days 1 to 7 in 21-day cycles. The recommended phase II dose (RP2D) was determined on the basis of safety, tolerability, pharmacokinetics (PK), and by mRNA expression of the p53 target gene pleckstrin homology-like domain, family A, member 3 ( PHLDA3). Other objectives were to characterize the PK/pharmacodynamic (PD) relationship, correlate biomarkers with response, and assess tumor response.ResultsForty-seven patients received MK-8242 across eight doses that ranged from 60 to 500 mg. Initially, six patients developed dose-limiting toxicities (DLTs): grade (G) 2 nausea at 120 mg; G3 fatigue at 250 mg; G2 nausea and G4 thrombocytopenia at 350 mg; and G3 vomiting and G3 diarrhea at 500 mg. DLT criteria were revised to permit management of GI toxicities. Dosing was resumed at 400 mg, and four additional DLTs were observed: G4 neutropenia and G4 thrombocytopenia at 400 mg and G4 thrombocytopenia (two patients) at 500 mg. Other drug-related G3 and G4 events included anemia, leukopenia, pancytopenia, nausea, hyperbilirubinemia, hypophosphatemia, and anorexia. On the basis of safety, tolerability, PK, and PD, the RP2D was established at 400 mg (15 evaluable patients experienced two DLTs). PK for 400 mg (day 7) showed Cmax 3.07 μM, Tmax 3.0 hours, t1/2 (half-life) 6.6 hours, CL/F (apparent clearance) 28.9 L/h, and Vd/F (apparent volume) 274 L. Blood PHLDA3 mRNA expression correlated with drug exposure ( R2= 0.68; P < .001). In 41 patients with postbaseline scans, three patients with liposarcoma achieved a partial response (at 250, 400, and 500 mg), 31 showed stable disease, and eight had progressive disease. In total, 27 patients with liposarcoma had a median progression-free survival of 237 days.ConclusionAt the RP2D of 400 mg twice a day, MK-8242 activated the p53 pathway with an acceptable safety and tolerability profile. The observed clinical activity (partial response and prolonged progression-free survival) provides an impetus for further study of HDM2 inhibitors in liposarcoma.
Managing Production-Inventory Systems with Scarce Resources
Authors: Benjaafar Saif , Chen David , Wang Rowan 
Published: February 2017

We consider the problem of managing production in a production-inventory system where a firm is subject to an allowance (a limit) on either the amount of input it can use or the amount of output it can produce over a specified compliance period (in addition to being subject to a constraint on the production capacity). Examples of such settings are numerous and include those where limits are placed on the use of scarce natural resources as input or on the amount of waste or harmful pollution generated by production as output. We study the structure of the optimal production policy for such systems and show that it is determined by dynamic thresholds that depend only on the sum of the on-hand inventory level and the remaining allowance. We provide an effective approximate solution approach that can compute these thresholds efficiently while retaining their essential properties. We examine the differences between how an allowance constraint and a constraint on production capacity affect production decisions and show that they exhibit opposite effects over time. We also examine, in the context of an extended version of the problem where both the allowance amount and the production capacity are endogenous, optimal investments in allowance and production capacity and the impact of both on firm profit. We also consider the optimal demand fulfillment policy in settings where the firm can decide whether to back-order or to reject demand that cannot be satisfied from on-hand inventory. The online appendix is available at https://doi.org/10.1287/msom.2016.0603 .
Effectivity of BS4 enzyme complex on the performance of laying hens fed with different ingredients
Authors: Sinurat Arnold P. , Purwadaria Tresnawati , Haryati Tuti 
Published: February 2017

<p class="abstrak2">An experiment was carried out to evaluate the effectivity of an enzyme complex produced by Eupenicilium javanicum BS4 on the performance of laying hens fed with different feed ingredients. Three diets were formulated with similar nutrients (protein, ME, digestible amino acids, Ca and available P) value to meet the nutrient requirement of laying hens. Diets were formulated based on maize, palm kernel cake (PKC) or rice bran. The diets were either supplemented or not with BS4 enzyme complex and fed to Isa Brown pullet from 19 to 37 weeks old. Each diet was fed to 24 birds and the performances were recorded. Data were analysed statistically with 2 X 3 factorial design with six replicates. Results showed that supplementation of BS4 enzyme into laying hens diet did not influence body weight change, feed intake, mortalities, egg weight and egg shell thickness but significantly increased egg production (P&lt;0.05) and the FCR (P&lt;0.01) in any feedstuff tested. It also improved egg yolk colour score on diet contained 20% PKC. Laying hens fed 20% PKC produced more eggs than those fed maize or rice bran. The egg shell of laying hens fed rice bran were thicker than those fed with maize or PKC. It is concluded that BS4 enzyme complex is effective when supplemented into laying hens diet.</p>
In vitro rumen fermentation characteristics and microbes of thin tail sheep given sweet potato (Ipomoea batatas L) biomass
Authors: Sudarman Asep , Hayashida M. , Miralestari M. 
Published: February 2017

<p class="abstrak2">Sweet potato plant is produced in Indonesia in large quantities. Sweet potato leaves and stems can be used as a source of protein and the tuber can be used as an energy source. This study was aimed to analyze the effect of feeding of sweet potato biomass on the rumen fermentation characteristics, digestibility of dry matter and organic matter as well as rumen microbial population of thin tail sheep. This study used a randomized block design by applying four feed treatments, i.e., T0 (100% Napier grass), T1 (70% of Napier grass + 30% concentrate), T2 (50% of Napier grass + 50% sweet potato leaves), and T3 (70% sweet potato leaves + 30% sweet potato tuber) with three replicates. Rumen fluid samples were taken with stomach tube method using a vacuum pump. Results showed that the T3 diet has higher (P&lt;0.05) digestibility of dry matter and organic matter, concentration of NH<sub>3</sub> and VFA, and rumen bacterial population than those of T0 and T1diets but similar to that of T2 diet. Rumen pH and protozoa population was not different among the treatments. It can be concluded that the use of sweet potato biomass can improve the quality of rumen fermentation of sheep.</p>
New Trends in Tourism Destination Branding by Means of Digital Marketing
Authors: Parlov Natalija , Perkov Davor , Sičaja Željko 
Published: February 2017

AbstractContemporary business is largely based on digital information. Traditional media forms lose battle in a new global surrounding. Therefore, knowing specific terminology and postulates of new conditions in the digital information market is essential. Globalization is an inevitable process overtaking all economic activities, including tourism sector intertwined with various advertising activities in order to place and sell its products and services. Digital marketing is thus more and more used. In that context, world tourism organizations and national tourist agencies play a role of communicator, trying to create desired mental image of a specific country as a tourism destination in the minds of final consumers. They use branding to make one country uniquely recognizable in the market. The aim of this paper is to present new trends in tourism destination branding process by using the means of digital marketing. The main purpose of this research was to analyse marketing activities and communication strategies of European countries, perceived as the largest tourism market, and compare them with the tourism promotion of Croatia in various markets. The results of the analysis of Croatian activities in promoting its tourism destinations imply there is still a large potential to improve implementation of digital marketing means by preparing the strategy of integrated market communication. The analysis of marketing activities of tourism developed countries shows trends in digital marketing that can serve as a model for development of Croatian tourism brand in global digital surrounding.
Comparative Analysis of American and European Yachtsman Profile for Better Marketing Placement of Croatia as Tourism Destination
Authors: Andrijanić Ivo , Parlov Natalija 
Published: February 2017

AbstractCountries develop their nautical tourism depending on their nature potentials and resources and in line with their national economic strategies. The main development determinant is a national strategy as the basis of all plans and activities. The nautical tourism development encourages tourism destination development and impacts on economic and social sustainability. Nautical tourism is a specific form of modern tourism trends whose extremely important and highly profitable economic influence is largely visible in numerous multiplicative effects. Renown world researches prove that nautical tourism is one of the most important economic activities in tourism sector, perceived in Croatia as one of the most competitive tourism products. The objective of this paper is to point at the necessity of differentiation of communication strategy and marketing placements towards target markets focused on attracting yachtsmen taking into account their different demographic and sociographic profile. The research and comparative analysis conducted in American and European yacht clubs showed significant differences in selection of tourism destinations based on demographic and sociographic profile of yachtsmen in specific geolocation. The purpose of this work is to prepare the comparative analysis of the European and American yachtsmen profiles, which will serve to create targeted strategic marketing model of attracting foreign yachtsmen in selection of their holiday tourism destination. The conclusions of this research show that Croatia has still not fully capitalized its potential in the nautical tourism sector and that the more comprehensive market segmentation is necessary in the process of planning how to attract foreign yachtsmen.
Down the Rabbit Hole 11/22/63: Stephen King’s Historical Changeling
Authors: Latham Betty 
Published: February 2017

Abstract
Once something becomes a story and it is appropriated in some way, that story experiences an additional, altered life. The adaptation might echo the original, but it does so in such a way that the original is forever changed. The original becomes a “changeling.” On a personal level we view events that we have “witnessed” through the lens of our own experiences. This is even true when one revisits the past through fiction. The reader or spectator experiences the past through the lens of the adapter. Stephen King admitted to being emotionally invested in the events surrounding the assassination of President John Fitzgerald Kennedy in 1963, and this emotional investment is reflected in his adaptation. Stephen King’s novel, 11-22-63, and its TV adaptation, serve as compelling examples of how emotional responses to the past can inform their adaptations, alter how their audiences explore and re-visit the past, and demonstrate how history and adaptations become changelings. King’s adaptation additionally demonstrates his ability to integrate the Kennedy assassination back into popular culture, inviting and allowing a “new” younger audience (who were not alive at the time of the assassination) to “experience” history by accompanying his characters down the rabbit hole of history.