bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolomics integrated with network pharmacology of blood-entry constituents reveals the bioactive component of Xuefu Zhuyu decoction and its angiogenic effects in treating traumatic brain injury
Authors: Li Teng , Zhang Lianglin , Cheng Menghan , Hu En , Yan Qiuju , Wu Yao , Luo Weikang , Su Hong , Yu Zhe , Guo Xin , Chen Quan , Zheng Fei , Li Haigang , Zhang Wei , Tang Tao , Luo Jiekun , Wang Yang 
Published: September 2024

Abstract
Background
Xuefu Zhuyu decoction (XFZYD) has been extensively utilized to treat traumatic brain injury (TBI). However, the bioactive compounds and the underlying mechanisms have not yet been elucidated.

Objectives
This study aimed to investigate the bioactive constituents of XFYZD that are absorbed in the blood and the mechanisms in treating TBI.

Methods
The study presents an integrated strategy in three steps to investigate the material basis and pharmacological mechanisms of XFZYD. The first step involves: (1) performing metabolomics analysis of XFZYD to obtain the main functions and targets; (2) screening the blood-entry ingredients and targets of XFZYD from databases; (3) obtaining the potential components targeting the key functions by integrated analysis of metabolomics and network pharmacology. The second step involves screening pharmacological effects with active ingredients in vitro. In the third step, the effects of the top active compound were validated in vivo, and the mechanisms were explored by protein antagonist experiments.

Results
Metabolomics analysis revealed that XFZYD treated TBI mice mainly through affecting the functions of blood vessels. We screened 62 blood-entry ingredients of XFZYD by network pharmacology. Then, we focused on 39 blood-entry ingredients related to vascular genes enriched by XFZYD-responsive metabolites. Performing the natural products library, we verified that hydroxysafflor yellow A (HSYA), vanillin, ligustilide, paeoniflorin, and other substances promoted endothelial cell proliferation significantly compared to the control group. Among them, the efficacy of HSYA was superior. Further animal studies demonstrated that HSYA treatment alleviated neurological dysfunction in TBI mice by mNSS and foot fault test, and decreased neuronal damage by HE, nissl, and TUNEL staining. HSYA increased the density of cerebral microvessels, raised the expression of angiogenesis marker proteins VEGFA and CD34, and activated the PI3K/Akt/mTOR signaling pathway significantly. The angiogenic effects disappeared after the intervention of PI3K antagonist LY294002.

Conclusion
By applying a novel strategy of integrating network pharmacology of constituents absorbed in blood with metabolomics, the research screened HSYA as one of the top bioactive constituents of XFZYD, which stimulates angiogenesis by activating the PI3K/Akt/mTOR signaling pathway after TBI.
Thalattosauria in time and space: a review of thalattosaur spatiotemporal occurrences, presumed evolutionary relationships and current ecological hypotheses
Authors: Bastiaans Dylan 
Published: September 2024

AbstractIn the wake of the greatest mass extinction in Earth’s history, the End-Permian Mass Extinction, the Triassic was a time of recovery and innovation. Aided by warm climatic conditions and favorable ecological circumstances, many reptilian clades originated and rapidly diversified during this time. This set the stage for numerous independent invasions of the marine realm by several reptilian clades, such as Ichthyosauriformes and Sauropterygia, shaping the oceanic ecosystems for the entire Mesozoic. Although comparatively less speciose, and temporally and latitudinally more restricted, another marine reptile clade, the Thalattosauriformes, stands out because of their unusual and highly disparate cranial, dental and skeletal morphology. Research on Thalattosauriformes has been hampered by a historic dearth of material, with the exception of rare material from Lagerstätten and highly fossiliferous localities, such as that from the UNESCO world heritage site of Monte San Giorgio. Consequently, their evolutionary origins and paleobiology remain poorly understood. The recent influx of new material from southwestern China and North America has renewed interest in this enigmatic group prompting the need for a detailed review of historic work and current views. The earliest representatives of the group may have been present from the late Early Triassic onwards in British Columbia. By the Ladinian the group had achieved a wide distribution across the northern hemisphere, spanning the eastern Panthalassic as well as the eastern and western Tethyan provinces. Distinct morphological and likely ecological differences exist between the two major clades of Thalattosauriformes, the Askeptosauroidea and the Thalattosauroidea, with the latter showing a higher degree of cranial and skeletal morphological disparity. In-group relationships remain poorly resolved beyond this bipartition. Overall, thalattosaurs may be closely related to other marine reptile groups such as ichthyopterygians and sauropterygians. However, their exact position within Diapsida remains elusive. Future focal points should utilize modern digital paleontological approaches to explore the many fragmentary specimens of otherwise poorly sampled localities.
Improving contraceptive care for minors in Israel: practice, policy, and training gaps among OBGYNs
Authors: Peled-Raz Maya , Goldstick Orly 
Published: September 2024

Abstract
Background
Sexually active adolescents sometimes seek contraceptives without parental consent, posing challenges due to minors' confidentiality and consent regulations. This is especially the case under the un-nuanced Israeli legal scheme regarding adolescents' care.

Methods
Israeli OBGYNs were contacted through mailing lists and social media groups and asked to fill an online questionnaire regarding their experience and protocols concerning prescription of contraceptives to minors. They were also asked about their comprehension of the relevant legal obligations, the importance they ascribe to different ethical interests and considerations, as well as their training.

Results
Of the 177 responding gynecologists, 132 (74.58%) consulted minors about contraceptives during the past year, regardless of a vast lack of training on providing care to minors. More than a third of respondents believed that there is no legal requirement to involve parents in the process, and only 8% assumed a legal obligation for parental involvement in all minors under the age of 18. Three quarters would "almost always" prescribe contraceptives without parental knowledge, if requested, while 20% never would. No correlation was found between respondents' practices and their perception of the relevant legal obligations. Participants agreed that the risk to the health of the minor as a result of having sex without contraceptives is of utmost importance. Yet, those willing to prescribe gave greater weight to this consideration, while those who do not prescribe were more concerned with the legal ramifications of such an act. The majority identified the age of 15 as the threshold for consistently prescribing contraceptives to minors without parental involvement.

Conclusion
This study highlights the significant gaps in both the legal framework and the training of Israeli OBGYNs, and further supports confidential prescription of contraceptives to minors 15 years and older, via Article 6 of the Israeli Legal Competence and Guardianship Law. Legislative reform, professional guidelines and education and training programs are all needed to ensure consistent and legally sound practices, that safeguard the health and rights of minors. It is imperative to guide healthcare providers, including OBGYNs prescribing contraceptives to minors, on managing the care of minors refusing parental involvement, clarifying the legal framework and ethical considerations involved.
Current status of the sterile insect technique for the suppression of mosquito populations on a global scale
Authors: Bouyer Jérémy 
Published: September 2024

AbstractBackgroundThe World Health Organization (WHO) has emphasized the urgent need for alternative strategies to chemical insecticides for controlling mosquito populations, particularly the invasiveAedesspecies, which are known vectors of arboviruses. Among these alternative approaches, the sterile insect technique (SIT) is experiencing rapid development, with numerous pilot trials being conducted worldwide.Main textThis review aims to elucidate the principles of SIT and highlight the significant recent advancements that have facilitated its scalability. I also employ a phased conditional approach to categorize the progression of 39 projects, drawing on peer reviewed studies, press releases and direct communication with project managers. This review indicates that a substantial number of projects illustrate the efficacy of SIT in suppressingAedespopulations, with one project even demonstrating a reduction in dengue incidence. I offer several recommendations to mitigate potential failures and address the challenges of compensation and overcompensation when implementing SIT field trials. Furthermore, I examine the potential implications of male mating harassment on the effectiveness of SIT in reducing disease transmission.ConclusionsThis comprehensive assessment underscores the promise of SIT as a viable strategy for mosquito control. The insights gained from these trials not only contribute to the understanding of SIT’s effectiveness but also highlight the importance of careful project management and ecological considerations in the pursuit of public health objectives.Graphical Abstract
Association of Maternal Short Sleep Duration With Neurodevelopmental Delay in Offspring: A Prospective Cohort Study
Authors: Zhang Lei , Wang Hai-xia , Li Wen-xiang , Zhu Yuan-yuan , Ma Rui-rui , Wang Yu-hong , Zhang Yu , Zhu Dao-min , Zhu Peng 
Published: September 2024

AbstractContextTo investigate how short sleep duration (SSD) during pregnancy is related to neurodevelopmental delays in offspring, we aimed to inform pregnancy sleep guidelines and promote maternal health and child development.ObjectiveTo identify the associations between SSD during pregnancy and offspring neurodevelopmental delay and to determine whether fetal glucose metabolism plays a role in SSD and neurodevelopmental delays.MethodsThis cohort study followed 7059 mother–child pairs from the Maternal & Infants Health in Hefei cohort, and collected sleep data during pregnancy via the Pittsburgh Sleep Quality Index at weeks 24 to 28 and 32 to 36. Neurodevelopmental outcomes from 6 to 36 months postpartum were assessed via the Denver Developmental Screening Test-II and the Gesell Development Diagnosis Scale. Cox proportional hazard regression was used to analyze the link between maternal SSD and neurodevelopmental delay risk. Mediation analysis was used to evaluate the role of cord blood serum C-peptide levels. Three hospitals and children's health centers in Hefei were involved.ResultsThe stratified analysis revealed a significant association between mothers with SSD during midpregnancy and neurodevelopmental delay in boys (adjusted HR 2.05, 95% CI 1.29, 3.25). Cord blood marker analysis revealed a positive relationship between cord blood serum C-peptide levels and neurodevelopmental delay in offspring (RR 0.04, 95% CI 0.00, 0.08). The proportion of the association between SSD and neurodevelopmental delay mediated by cord blood C-peptide was 11.05%.ConclusionMaternal SSD during pregnancy was continuously associated with an increased incidence of neurodevelopmental delay with sex differences among offspring. This association may be mediated in part by increased higher levels of cord C-peptide.
Family Planning and Children's Human Capital: Experimental Evidence From Urban Malawi
Authors: Maggio Daniel , Karra Mahesh , Canning David 
Published: September 2024

Abstract
We conduct a randomized controlled trial that provides pregnant and immediate postpartum women with improved access to family planning through counseling, free transportation to a clinic, and financial reimbursement for family planning services over two years. We study the effects of our intervention on child growth and development outcomes among 1,034 children born to participating women directly before the intervention rollout. We find that children born to mothers assigned to the family planning intervention arm were 0.28–0.34 standard deviations taller for their age and 10.7–12.0 percentage points less likely to be stunted within a year of exposure to the intervention. Children born to mothers assigned to the intervention arm also scored 0.17–0.20 standard deviations higher on a caregiver-reported measure of cognitive development after two years of intervention exposure. Although the nonmeasurement of children is a challenge in our study, our estimates are robust to multiple methods of correcting for potential attrition bias. Our results are consistent with models of fertility that link couples’ fertility decisions to child health and human capital. Our results also suggest that improved access to family planning might have positive downstream effects on child health beyond contraceptive use and fertility outcomes.
The Effect of Transpedicular Injection of Recombinant Human Bone Morphogenetic Protein-2/Beta‐Tricalcium Phosphate Carrier on the Prevention of Proximal Junctional Kyphosis in Adult Spinal Deformity Surgery: A Pilot Study
Authors: Park Jin-Ho , Choi Jun-Young , Kwon Ohsang , Yeom Jin S. , Park Sang-Min , Song Wonho , Kim Ho-Joong 
Published: September 2024

BACKGROUND AND OBJECTIVES:
Several studies have explored strategies to prevent proximal junctional kyphosis (PJK) which is the unresolved issue in adult spinal deformity (ASD) surgery. This study aimed to investigate the preventive effects of upper instrumented vertebrae (UIV) recombinant human bone morphogenetic protein-2 (rhBMP-2) with beta‐tricalcium phosphate (β-TCP) carrier injection on PJK.

METHODS:
This study was conducted through a retrospective analysis of data collected both prospectively and retrospectively. In the rhBMP-2 group, consisting of 25 patients with ASD, rhBMP-2 along with β-TCP carrier was administered to the UIV through the pedicle. To minimize time-related bias, control-1 included 66 patients who had undergone ASD surgery by the same surgeon in the year preceding the commencement of the study. Control-2 consisted of 63 patients who had undergone ASD surgery by the same surgeon during the year after the end of the study. The primary outcome is the occurrence of PJK within one year postsurgery, and the secondary outcome is the change in Hounsfield unit of the UIV one year after the surgery.

RESULTS:
When comparing baseline characteristics with control groups, a significant difference was observed only in body mass index, with control-1 (P = .006) and control-total (control-1 + control-2, P = .026) having a higher body mass index than the study group. In the rhBMP-2 group, there were 3 cases (PJK rate, 12.0%) of PJK, whereas control-1 and control-2 had 26 cases (PJK rate, 39.4%, P = .012) and 20 cases (PJK rate, 31.7%, P = .057), respectively. In the control-total, there were 46 cases (PJK rate, 35.7%, P = .020) of PJK. The UIV that received rhBMP-2 showed a statistically significant increase in Hounsfield unit measurements compared to preoperative values 1 year after surgery (P = .001).

CONCLUSION:
The transpedicular injection of rhBMP-2/β-TCP carrier at the UIV significantly contributed to the prevention of PJK and effectively increased trabecular bone density at the UIV.
Community involvement as a mediating variable: How social media marketing activities affects customer loyalty?
Authors: Yasmin Annisa , Helmi Arief , Komaladewi Rita , Deborah Irene , Naufal Ariq Zulfahmi 
Published: September 2024

The cosmetics industry in Indonesia has great potential, posing great challenges to maintain competitiveness. This research examines community engagement's role as a mediating factor between social media marketing activities and customer loyalty. 194 respondents completed questionnaires to provide study data, which was then analyzed using Smart PLS version 3.0. The findings showed the beneficial effects of social media marketing activities on community engagement and customer loyalty. Furthermore, it has been demonstrated that community engagement increases customer loyalty. However, the results show that community engagement does not mediate between social media marketing activities and customer loyalty. This research highlights the importance of integrating social media into marketing campaigns to foster customer relationships and boost loyalty.
Technology acceptance model theory on intention to use e-recruitment
Authors: Azzatillah Azzatillah , Nada Lifatin , Rahmadina Dean Seshar , Chairunnisa Chairunnisa , Savira Dhelvianti Azni 
Published: September 2024

Currently, e-recruitment activities are human resource digitalization activities that not only change the perspective of job seekers about finding and applying for jobs but also change the way organizations attract new candidates to job positions. This study examines and analyzes the intention to use e-recruitment using the development of the theory of technology acceptance model 2. The quantitative method is the research method used in this study. The sample collection used purposive random sampling through an online questionnaire to obtain a sample of 177 respondents. The analysis in this study uses a variant-based structural equation model with partial least squares. The analysis results indirectly show that someone with a subjective norm will have a higher perceived usefulness of e-recruitment, affecting the higher intention to use e-recruitment. This also happens to someone who has a perceived ease of use of e-recruitment, which will increase the perceived usefulness of e-recruitment, increasing the intention to use e-recruitment. Subjective norm will directly affect someone's intention to use and perceived usefulness of e-recruitment; perceived usefulness will affect intention to use e-recruitment; and perceived ease of use will influence perceived usefulness and intention to use e-recruitment.
Família, morte e cultura material na era das rebeliões
Authors: Belmonte Alexandre 
Published: September 2024

A complexa e gigantesca máquina burocrática da administração espanhola de suas colônias deixou de legado um dos mais importantes espólios documentais do ponto de vista de como a sociedade hispano-americana se pensava, que bens seus diversos segmentos sociais possuíam, como lidavam com questões legais e de legitimidade, e como estavam constituídas as famílias. Trata-se dos testamentos e inventários de bens. São documentos legais, de natureza tanto espiritual quanto jurídica, escritos por um escrivão em papel timbrado do estado, conformados por diversas cláusulas que versam, dentre outras coisas, sobre a salvação da alma, o reconhecimento de filhos ilegítimos e a distribuição de bens na forma de herança. De acordo com as cláusulas dos testamentos, se podem perceber e analisar uma série de aspectos da vida cotidiana da sociedade colonial: se reconhece a proveniência geográfica e étnica do testador, sua idade, seu endereço e conformação familiar, seu estado de saúde, sua religiosidade, práticas funerárias e de enterro, seu estado civil e descendência, os bens materiais que possuía, suas relações familiares e sociais, sua relação com a Igreja etc. Evidentemente, nem todos esses elementos estão presentes o tempo todo em todos os testamentos. O objetivo desta pesquisa é analisar as diferentes configurações familiares depreendidas a partir dos testamentos, determinando a relação do testador com a morte iminente, bem como suas condições de vida enquanto indígenas, pela análise dos bens que deixa a seus herdeiros. A documentação selecionada para esta pesquisa é constituída por 30 testamentos de indígenas; 12 testamentos e inventários de criollos e padres espanhóis, da Audiência de Charcas, entre as décadas de 1750 e 1790; e 10 testamentos variados dos séculos XVI e XVII. O material foi identificado, recolhido e adquirido no Archivo y Biblioteca Nacionales de Bolivia e no Archivo Histórico de Potosí-Casa de la Moneda, entre 2019 e 2021.
Validity of handgrip strength for assessing cognition and psychotic symptoms in hospitalized patients with stable schizophrenia
Authors: Pu Jianlin , Wang Binyou , Wang Yilin 
Published: September 2024

Background and objectives
A correlation between low handgrip strength (HGS), HGS asymmetry, and low cognitive performance has been demonstrated. However, it remains unclear whether low HGS is associated with psychotic symptoms and whether HGS asymmetry is associated with cognitive and psychotic symptoms in hospitalized patients with schizophrenia. This study aimed to investigate the validity of HGS as a measure for assessing cognition and psychotic symptoms in hospitalized patients with stable schizophrenia.

Methods
A total of 235 inpatients with stable schizophrenia were recruited between August 1, 2023, and August 31, 2023. The highest HGS values from three tests on the dominant hand were used to determine low HGS (male < 28 kg, female < 18 kg), and HGS asymmetry was identified when the non-dominant HGS/dominant HGS ratio was outside 0.9–1.1. Cognition and psychotic symptoms were assessed using the Chinese Montreal Cognitive Assessment (MoCA-C) and Positive and Negative Syndrome Scale (PANSS). Generalized linear model analyses examined the relationship between HGS and scale scores.

Results
Covariate-adjusted generalized linear models confirmed a strong association between low HGS alone and the MoCA-C score (OR = 0.819, 95% CI = 0.710‒0.945, p = 0.006) and PANSS score (OR = 1.113, 95% CI = 1.036‒1.239, p = 0.006). Similarly, the combination of low and asymmetric HGS was strongly associated with both MoCA-C (OR = 0.748, 95% CI = 0.653‒0.857, p<0.001) and PANSS scores (OR = 1.118, 95% CI = 1.032‒1.211, p = 0.006).

Conclusions
The results suggest that hospitalized patients with schizophrenia and low HGS, with or without asymmetry, are likely to have lower MoCA-C scores and higher PANSS scores. Screening stable schizophrenia patients with low HGS, with or without asymmetry, could be a valuable and straightforward approach to identifying those with lower cognition and severe psychotic symptoms.