bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les Portugais dans l'entourage de la duchesse de Bourgogne Isabelle de Portugal (1430-1471).
Authors: Sommé Monique 
Published: April 2016

The Portuguese Familiars of the Duchess of Burgundy, Isabelle de Portugal (1430-1471).
The presence of Portuguese fellowmen, arrived with her in 1430 or later around 1450, among Isabelle de Portugal's familiar is revealed by the Burgundy accounts and the mortgage-bond entry of her mansion. The men hold offices that place them in the duchess's vicinity, they are paid regular wages and some of them are awarded a charge in her property. The maids of honour, who are also paid wages after 1445, are richly endowed and given in marriage by Isabelle, according to their rank. Jean, Jacques and Béatrice de Coïmbre, her nephews and niece who had taken refuge in Flanders, benefited from her protection and generosity, especially Béatrice, as demonstrated by her marriage contract with Adolphe de Clèves in 1453, edited in Annex.
A 12-YEAR ACTIVITY CYCLE FOR THE NEARBY PLANET HOST STAR HD 219134
Authors: Johnson Marshall C. , Endl Michael , Cochran William D. , Meschiari Stefano , Robertson Paul , MacQueen Phillip J. , Brugamyer Erik J. , Caldwell Caroline , Hatzes Artie P. , Ramírez Ivan , Wittenmyer Robert A. 
Published: April 2016

ABSTRACT
The nearby (6.5 pc) star HD 219134 was recently shown by Motalebi et al. and Vogt et al. to host several planets, the innermost of which is transiting. We present 27 years of radial velocity (RV) observations of this star from the McDonald Observatory Planet Search program, and 19 years of stellar activity data. We detect a long-period activity cycle measured in the Ca ii
S
HK index, with a period of 4230 ± 100 days (11.7 years), very similar to the 11 year solar activity cycle. Although the period of the Saturn-mass planet HD 219134 h is close to half that of the activity cycle, we argue that it is not an artifact due to stellar activity. We also find a significant periodicity in the S
HK data due to stellar rotation with a period of 22.8 days. This is identical to the period of planet f identified by Vogt et al., suggesting that this RV signal might be caused by rotational modulation of stellar activity rather than a planet. Analysis of our RVs allows us to detect the long-period planet HD 219134 h and the transiting super-Earth HD 219134 b. Finally, we use our long time baseline to constrain the presence of longer period planets in the system, excluding to

1
σ

objects with

M
sin
i
>
0.36

M

J

at 12 years (corresponding to the orbital period of Jupiter) and

M
sin
i
>
0.72

M

J

at a period of 16.4 years (assuming a circular orbit for an outer companion).
AN ADVANCED LEAKAGE SCHEME FOR NEUTRINO TREATMENT IN ASTROPHYSICAL SIMULATIONS
Authors: Perego A. , Cabezón R. M. , Käppeli R. 
Published: April 2016

ABSTRACT
We present an Advanced Spectral Leakage (ASL) scheme to model neutrinos in the context of core-collapse supernovae (CCSNe) and compact binary mergers. Based on previous gray leakage schemes, the ASL scheme computes the neutrino cooling rates by interpolating local production and diffusion rates (relevant in optically thin and thick regimes, respectively) separately for discretized values of the neutrino energy. Neutrino trapped components are also modeled, based on equilibrium and timescale arguments. The better accuracy achieved by the spectral treatment allows a more reliable computation of neutrino heating rates in optically thin conditions. The scheme has been calibrated and tested against Boltzmann transport in the context of Newtonian spherically symmetric models of CCSNe. ASL shows a very good qualitative and a partial quantitative agreement for key quantities from collapse to a few hundreds of milliseconds after core bounce. We have proved the adaptability and flexibility of our ASL scheme, coupling it to an axisymmetric Eulerian and to a three-dimensional smoothed particle hydrodynamics code to simulate core collapse. Therefore, the neutrino treatment presented here is ideal for large parameter-space explorations, parametric studies, high-resolution tests, code developments, and long-term modeling of asymmetric configurations, where more detailed neutrino treatments are not available or are currently computationally too expensive.
La rue parisienne au xix e siècle : standardisation et contrôle ?
Authors: Barles Sabine 
Published: April 2016

Au xix e siècle, la voirie parisienne est profondément transformée par les deux préfectures qui en assurent la gestion, de Police et de la Seine, mais aussi par la diversification des véhicules et l’intensification de la circulation qui viennent ajouter à l’encombrement chronique de l’espace public. La reconfiguration du réseau viaire – rues plus larges, plus lisses, revêtues, dotées de trottoirs, éclairées, débarrassées des activités jugées inutiles – est associée au développement d’une réglementation pléthorique visant à encadrer les usages de la rue et à organiser le torrent circulatoire. Cependant, la rue et ses usagers résistent à cette standardisation et à cette mise en ordre : la rue demeure très animée, parfois violente, toujours bruyante.
mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production
Authors: Chen Feidi , Cao Anthony , Yao Suxia , Evans-Marin Heather L. , Liu Han , Wu Wei , Carlsen Eric D. , Dann Sara M. , Soong Lynn , Sun Jiaren , Zhao Qihong , Cong Yingzi 
Published: April 2016

Abstract
It has been shown recently that neutrophils are able to produce IL-22 and IL-17, which differentially regulate the pathogenesis of inflammatory bowel disease. However, it is still largely unknown how the neutrophil production of IL-22 and IL-17 is regulated, and their role in the pathogenesis of inflammatory bowel disease. In this study, we found that IL-23 promoted neutrophil production of IL-17 and IL-22. IL-23 stimulated the neutrophil expression of IL-23R as well as rorc and ahr. Retinoid acid receptor–related orphan receptor γ t and aryl-hydrocarbon receptor differentially regulated IL-23 induction of neutrophil IL-17 and IL-22. In addition, IL-23 induced the activation of mTOR in neutrophils. Blockade of the mTOR pathway inhibited IL-23–induced expression of rorc and ahr, as well as IL-17 and IL-22 production. By using a microbiota Ag-specific T cell–mediated colitis model, we demonstrated that depletion of neutrophils, as well as blockade of IL-22, resulted in a significant increase in the severity of colitis, thereby indicating a protective role of neutrophils and IL-22 in chronic colitis. Collectively, our data revealed that neutrophils negatively regulate microbiota Ag-specific T cell induction of colitis, and IL-23 induces neutrophil production of IL-22 and IL-17 through induction of rorc and ahr, which is mediated by the mTOR pathway.
Nonrhabdomyosarcomatous abdominopelvic sarcomas: Analysis of prognostic factors
Authors: Iqbal Nida , Shukla Nootan K , Deo S. V. S. , Agarwala Sandeep , Sharma D , Sharma Meher C , Bakhshi Sameer 
Published: April 2016

Abstract
Background: Data concerning treatment outcome and prognostic factors in sarcomas of abdomen and pelvis are sparse in literature.Methods and Results: Of 696 patients with nonrhabdomyosarcomatous soft tissue sarcoma registered at our center between June 2003 and December 2012, 112 (16%) patients of sarcomas arising from abdomen and pelvis were identified, of which 88 patients were analyzed for treatment outcome and prognostic factors. The median age was 40 years (range: 1–78 years) with a male: female ratio of 0.7:1. Twenty-one (24%) patients were metastatic at baseline. The most common tumor sites were retroperitoneum in 70% patients and abdominal wall in 18% patients. Leiomyosarcoma was the most common histological subtype in 36% patients followed by liposarcoma in 17% patients. Thirty-five (40%) patients had Grade III tumors. Forty-six (52%) patients underwent surgical resection. At a median follow-up of 43 months (range: 2–94 months), the 5-year event-free survival (EFS) and overall survival (OS) were 35% and 42%, with a median of 22 months and 43 months, respectively. Multivariate analysis identified male gender (P - 0.03, hazard ratio [HR] - 0.46, 95% confidence interval [CI] - 0.23–0.92), baseline metastatic disease (P - 0.01, HR - 2.98, 95% CI - 1.27–6.98) and Grade III tumors (P - 0.02, HR - 1.84, 95% CI - 1.08–3.13) as factors associated with poor EFS, whereas baseline metastatic disease (P < 0.001, HR - 5.45, 95% CI - 2.31–12.87) and unresectability (P - 0.01, HR - 2.72, 95% CI - 1.27–5.83) were associated with poor OS. Conclusion: This is a single-institutional study of patients with abdominopelvic sarcomas where gender was identified as a new factor affecting survival apart from baseline presentation, histologic grade, and surgical resection.
Incidence of bone metastasis in carcinoma buccal mucosa
Authors: Bhandari Virendra 
Published: April 2016

Abstract
Introduction: Head and neck cancer is a leading health problem in India due to the habit of chewing tobacco and bad oral and dental hygiene. Carcinoma buccal mucosa is more common and is 2.5% of all malignancies at our center. Most of the patients present in stage III and IV and the survival in these cases is not very good. Bone metastasis in advanced cases of carcinoma buccal mucosa is rarely reported in the world literature. Materials and Methods: We present here cases developing bone metastasis in carcinoma buccal mucosa in last 5 years. These patients were young with loco-regionally advanced disease where bone metastasis developed within 1-year of definitive treatment. Results: The flat bones and vertebrae were mainly involved and the survival was also short after diagnosis of metastasis despite the treatment with local Radiotherapy and chemotherapy. Conclusion: The exact cause of metastasis cannot be proved, but the probability of subclinical seedling of malignant cells before the eradication of the primary tumor should be considered along with advanced local and nodal disease with high grade of tumor.
A cross-sectional observation study regarding patients and their physician willingness to wait for driver mutation report in nonsmall-cell lung cancer
Authors: Joshi Amit , Patil Vijay M , Noronha Vanita , Ghosh Joydeep , Bhattacharjee Atanu , Prabhash Kumar 
Published: April 2016

Abstract
Background: Palliative chemotherapy +/− targeted therapy in accordance with mutation profile is the norm in nonsmall-cell lung cancer (NSCLC). The objective of this audit was to determine the proportion of patients and physicians, who are unwilling to wait for the mutation report and the reasons thereof. Materials and Methods: All newly diagnosed NSCLC patients, post biopsy, seen at our center between November 2014 and January 2015 were included. The relationship between patient and physician decision and objective factors was explored by Fisher's exact test. The factors considered were Eastern Cooperative Oncology Group performance status (ECOG PS), the presence of a cough, hemoptysis, fatigue, and breathlessness. The agreement between patients and physician decision was tested by contingency table. Results: Out of 168 patients, 57 were unwilling to wait for driver mutation report (33.9% 95% confidence interval [CI] 27.2-41.4%). The most common reason provided by patients was symptomatic status (23, 40.1%). No other objective factor except PS (P = 0.00) was associated with patient's decision. In 56 patients (33.4% 95% CI 26.6-40.7%), physicians were unwilling to wait. Among the tested factors ECOG PS (P = 0.000), breathlessness (P = 0.00) and fatigue (P = 0.00) were associated with the decision of not waiting for the report. The percentage corrected value of contingency between patients and physician decision was 78.74%. Conclusion: At present, in our setup, nearly one-third of our NSCLC patients opt for immediate chemotherapy treatment and are unwilling to wait for mutation analysis report. The major reasons for such attitude is poor symptom control and deteriorating general condition.
Breast relapse after metastatic alveolar rhabdomyosarcoma: Is it an incurable entity?
Authors: Iniesta Silvia López , Cereceda Maria Tasso , Adams Chevorn Suzette , Menor Carlos Esquembre 
Published: April 2016

AbstractMetastatic breast disease is a very rare condition in children. Rhabdomyosarcoma (RMS) is the most common solid primary tumor in children, but only a few cases of breast metastases have been described. We present the case of a young female with a primary pelvic metastatic alveolar RMS, which metastasized to the breast twice and achieved prolonged complete remission with a multimodal approach.
Comparative evaluation of various cytomorphological grading systems in breast carcinoma
Authors: Arul P , Masilamani Suresh 
Published: April 2016

Abstract
Background: The diagnosis of breast carcinoma can be reliably made by fine needle aspiration cytology (FNAC). Grading usually done in histological samples for the selection of therapy but not in cytology. Various cytological grading systems have been proposed; however, none of them is presently considered the gold standard to predict the prognosis. Aim: This study was undertaken to evaluate various 3-tier cytological grading systems and to determine the best possible system corresponds to the histological grading proposed by Elston and Ellis based on the method by Nottingham modification of Scarff-Bloom-Richardson (SBR) method. Materials and Methods: In this retrospective study, 94 cases of breast carcinoma FNACs were graded using six cytological grading systems and compared with SBR method. Concordance, association, and correlation studies were done to select best possible cytological grading system. The interobserver reproducibility among the six grading systems was also assessed. Results: Robinson method showed best correlation (r = 0.801; P = 0.0001 and t = 0.783; P = 0.0001), maximum percent agreement (83/94 cases; 88.3%), and a substantial kappa value of agreement (k = 0.737) with the Nottingham modification of SBR grading system followed by Mouriguand method. Taniguchi system showed better interobserver agreement (87.2%; k= 0.738). Conclusions: This study showed that all six cytological grading systems correlated positively with SBR method. However, Robinson's grading system demonstrated the best concordance, correlation, and substantial Kappa value of the agreement with the histological grading by SBR method in comparison to other 3-tier cytological grading systems. Hence, in conclusion, this grading should be routinely incorporated in the cytology reports as it correlates well with histological grade. Despite various cytological grading systems, Robinson's method is simple, more objective, and reproducible, hence being preferable for routine use.
Effect of folate status and methylenetetrahydrofolate reductase genotypes on the complications and outcome of high dose methotrexate chemotherapy in north Indian children with acute lymphoblastic leukemia
Authors: Moulik Nirmalya Roy , Kumar Archana , Agrawal Suraksha , Mahdi Abbas Ali , Kumar Ashutosh 
Published: April 2016

Abstract
Purpose: The genes of the folate metabolic pathway have been associated with toxicities during high dose methotrexate therapy for childhood ALL, however, the importance of intrinsic folate status in this regard is unclear. Methods: In the present study the effect of precourse folate levels and MTHFR genotypes on the complications during high dose methotrexate chemotherapy in children with ALL were examined. Results: Twenty-one children were studied. Folate deficiency was associated with higher incidence of neutropenia (P = 0.03) and longer duration of chemotherapy interruption (P = 0.009). Children with MTHFR1298 mutations needed more red cell transfusion (P = 0.03). All 3 deaths encountered were seen in folate deficient children. Conclusions: Folate deficiency was associated with higher complications during high dose methotrexate therapy, the implications of which are important especially in resource poor settings with high prevalence of folate deficiency.
Adjuvant brachytherapy for Stage IB Grade 2 endometrial carcinoma: Multivariate analysis of a single institution experience
Authors: Tokar Margarita , Meirovich Michael , Bobilev Dmitri , Mermershtain Wilmosh 
Published: April 2016

Abstract
Objective: The aim was to investigate the value of postoperative brachytherapy for patients with Stage IB, Grade 2 endometrial carcinoma. Patients and Methods: Forty-six patients with Stage IB, Grade 2 endometrial carcinoma, were treated with simple hysterectomy and bilateral oophorectomy in our institution. The mean age was 63 (range, 42-81). Surgical staging, defined as peritoneal washing and pelvic lymph node sampling was performed in 73% of patients. Twenty-two patients (47%) received a postoperative intravaginal brachytherapy (IVRT), and 24 patients (53%) were followed-up without additional treatment. Results: The median follow-up was 60 months. The 5-year overall survival for irradiated and nonirradiated patients, was 83.5 and 94.7%, respectively. Four patients (8.7%) developed relapse, two in the group of postoperative IVRT and 2 in the follow-up only group. Multivariate analysis demonstrated a borderline association (P = 0.06) between lower uterine segment involvement and poor pelvic-vaginal control. The presence of GOG #99 high-risk features did not affect the pelvic control rate. Conclusion: According to our experience and previously published data, most patients with FIGO Stage IB, Grade 2 endometrial carcinoma may be cured with surgery alone.
Divergence-Free WENO Reconstruction-Based Finite Volume Scheme for Solving Ideal MHD Equations on Triangular Meshes
Authors: Xu Zhiliang , Balsara Dinshaw S. , Du Huijing 
Published: April 2016

AbstractIn this paper, we introduce a high-order accurate constrained transport type finite volume method to solve ideal magnetohydrodynamic equations on two-dimensional triangular meshes. A new divergence-free WENO-based reconstruction method is developed to maintain exactly divergence-free evolution of the numerical magnetic field. In this formulation, the normal component of the magnetic field at each face of a triangle is reconstructed uniquely and with the desired order of accuracy. Additionally, a new weighted flux interpolation approach is also developed to compute the z-component of the electric field at vertices of grid cells. We also present numerical examples to demonstrate the accuracy and robustness of the proposed scheme.
A Two-Stage Image Segmentation Model for Multi-Channel Images
Authors: Li Zhi , Zeng Tieyong 
Published: April 2016

AbstractThis paper introduces a two-stage model for multi-channel image segmentation, which is motivated by minimal surface theory. Indeed, in the first stage, we acquire a smooth solutionufrom a convex variational model related to minimal surface property and different data fidelity terms are considered. This minimization problem is solved efficiently by the classical primal-dual approach. In the second stage, we adopt thresholding to segment the smoothed imageu. Here, instead of using K-means to determine the thresholds, we propose a more stable hill-climbing procedure to locate the peaks on the 3D histogram ofuas thresholds, in the meantime, this algorithm can also detect the number of segments. Finally, numerical results demonstrate that the proposed method is very robust against noise and superior to other image segmentation approaches.
Mechanical design, analysis and testing of a large-range compliant microgripper
Authors: Liu Yilin , Xu Qingsong 
Published: April 2016

Abstract. This paper presents the mechanical design, analysis, fabrication, and testing procedures of a new large-range microgripper which is based on a flexible hinge structure. The uniqueness of the gripper is that the gripper arms not only provide large gripping range but also deliver approximately rectilinear movement as the displacement in nonworking direction is extremely small. The large gripping range is enabled by a mechanism design based on dual-stage flexure amplifier to magnify the stroke of piezoelectric actuator. The first-stage amplifier is a modified version of the Scott Russell (SR) mechanism and the second-stage amplifier contains a parallel mechanism. The displacement amplification ratio of the modified SR mechanism in the gripper has been enlarged to 3.56 times of the conventional design. Analytical static models of the gripper mechanism are developed and validated through finite-element analysis (FEA) simulation. Results show that the gripping range is over 720 µm with a resonant frequency of 70.7 Hz and negligible displacement in nonworking direction. The total amplification ratio of the input displacement is 16.13. Moreover, a prototype of the gripper is developed by using aluminium 7075 for experimental testing. Experimental results validate the analytical model and FEA simulation results. The proposed microgripper can be employed in various microassembly applications such as pick-and-place of optical fibre.
Characteristics of mesoscale-convective-system-produced extreme rainfall over southeastern South Korea: 7 July 2009
Authors: Jeong Jong-Hoon , Lee Dong-In , Wang Chung-Chieh , Han In-Seong 
Published: April 2016

Abstract. An extreme-rainfall-producing mesoscale convective system (MCS) associated with the Changma front in southeastern South Korea was investigated using observational data. This event recorded historic rainfall and led to devastating flash floods and landslides in the Busan metropolitan area on 7 July 2009. The aim of the present study is to analyse the influences for the synoptic and mesoscale environment, and the reasons that the quasi-stationary MCS causes extreme rainfall. Synoptic and mesoscale analyses indicate that the MCS and heavy rainfall occurred in association with a stationary front which resembled a warm front in structure. A strong southwesterly low-level jet (LLJ) transported warm and humid air and supplied the moisture toward the front, and the air rose upwards above the frontal surface. As the moist air was conditionally unstable, repeated upstream initiation of deep convection by back-building occurred at the coastline, while old cells moved downstream parallel to the convective line with training effect. Because the motion of convective cells nearly opposed the backward propagation, the system as a whole moved slowly. The back-building behaviour was linked to the convectively generated cold pool and its outflow boundary, which played a role in the propagation and maintenance of the rainfall system. As a result, the quasi-stationary MCS caused a prolonged duration of heavy rainfall, leading to extreme rainfall over the Busan metropolitan area.