bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac thrombus detected by cardiac computed tomography angiography in patients with acute ischemic stroke: a meta-analysis
Authors: Xu Buyun , Du Ye , Yu Zhangjie , Sun Yong , Xiang Meixiang 
Published: September 2024

BackgroundDetecting cardiac thrombus in patients with acute ischemic stroke is crucial in determine stroke etiology and predict prognosis. However, the prevalence of cardiac thrombus in patients with acute ischemic stroke is unclear.ObjectThis study aimed to evaluate the prevalence of cardiac thrombus detected by cardiac computed tomography angiography (CCTA) in patients with acute ischemic stroke through a meta-analysis.MethodsEmbase, Web of Science, MEDLINE, and CENTRAL were searched from January 1, 2000, to May 1, 2024. We included observational studies enrolling patients who underwent CCTA within 1 month following acute ischemic stroke, and reporting the incidence of cardiac thrombi on CCTA. Meta-analysis was performed using random effects models.ResultsTwenty-six studies involving 4,516 patients were identified. The pooled prevalence of cardiac thrombus detected on CCTA in patients with acute ischemic stroke was 0.08 (95% confidence interval [CI]: 0.06–0.11). Inter-study heterogeneity was high (I2 = 88%). Among stroke type, the prevalence of atrial fibrillation, timing of CCTA and CCTA technology, the prevalence of atrial fibrillation was the only factor associated with cardiac thrombi prevalence detected by CCTA. However, atrial fibrillation was not documented in 41.5% of the patients with cardiac thrombi.ConclusionCCTA is a useful non-invasive imaging approach for detecting cardiac thrombus in patients with acute ischemic stroke, which might be helpful to determine the stroke etiology.
The degenerate coding of psychometric profiles through functional connectivity archetypes
Authors: Di Plinio Simone , Northoff Georg , Ebisch Sjoerd 
Published: September 2024

IntroductionDegeneracy in the brain-behavior code refers to the brain’s ability to utilize different neural configurations to support similar functions, reflecting its adaptability and robustness. This study aims to explore degeneracy by investigating the non-linear associations between psychometric profiles and resting-state functional connectivity (RSFC).MethodsThe study analyzed RSFC data from 500 subjects to uncover the underlying neural configurations associated with various psychometric outcomes. Self-organized maps (SOM), a type of unsupervised machine learning algorithm, were employed to cluster the RSFC data. And identify distinct archetypal connectivity profiles characterized by unique within- and between-network connectivity patterns.ResultsThe clustering analysis using SOM revealed several distinct archetypal connectivity profiles within the RSFC data. Each archetype exhibited unique connectivity patterns that correlated with various cognitive, physical, and socioemotional outcomes. Notably, the interaction between different SOM dimensions was significantly associated with specific psychometric profiles.DiscussionThis study underscores the complexity of brain-behavior interactions and the brain’s capacity for degeneracy, where different neural configurations can lead to similar behavioral outcomes. These findings highlight the existence of multiple brain architectures capable of producing similar behavioral outcomes, illustrating the concept of neural degeneracy, and advance our understanding of neural degeneracy and its implications for cognitive and emotional health.
Asymmetry and rehabilitation of the subjective visual vertical in unilateral vestibular hypofunction patients
Authors: Haijoub Souad , Hautefort Charlotte , Toupet Michel , Lacour Michel 
Published: September 2024

AimsPatients with acute unilateral peripheral vestibular hypofunction (AUVP) show postural, ocular motor, and perceptive signs on the diseased side. The subjective visual vertical (SVV) test measures the perceived bias in earth-vertical orientation with a laser line in darkness. This study was aimed at (1) examining whether SVV bias could depend on preset line orientation and angles, and (2) investigating whether vestibular rehabilitation (VR) can improve SVV normalization. To our knowledge, SVV symmetry/asymmetry and impact of VR on SVV normalization have never been documented in the literature.Participants and methodsWe investigated the SVV bias in a retrospective study (Study 1: n = 42 AUVP patients) comparing the data recorded for line orientation to the ipsilateral and contralateral sides at preset angles of 15° and 30°. We investigated the effects of VR on SVV normalization in a prospective study (Study 2: n = 20 AUPV patients) in which patients were tilted in the roll plane using a support tilted to the hypofunction side with the same amplitude as the SVV bias. This VR protocol was performed twice a week for 4 weeks. Supplementary data on body weight distribution and medio-lateral position of the center of foot pressure (CoP) were obtained using posturography recordings.ResultsStudy 1 showed asymmetrical values of the SVV bias. On average, the SVV errors were significantly higher for ipsilateral compared to contralateral line orientation (6.98° ± 3.7° vs. 4.95° ± 3.6°; p &lt; 0.0001), and for 30° compared to 15° preset angle (6.76° ± 4.2° vs. 5.66° ± 3.3°; p &lt; 0.0001). Study 2 showed a fast SVV normalization with VR. Non-pathological SVV bias (below ±2°) was found after only 3 to 5 VR sessions while pathological SVV values were still observed at the same time after symptoms onset in patients without VR (1.25° ± 1.46° vs. 4.32° ± 2.81°, respectively; p &lt; 0.0001). A close temporal correlation was observed in the time course of body weight distribution, mediolateral CoP position, and SVV bias over time, suggesting beneficial effects of the VR protocol at both the perceptive and postural levels.ConclusionWe recommend routine assessment of the ipsilateral and contralateral SVV bias separately for a better evaluation of otolith organs imbalance that can trigger chronic instability and dizziness. The SVV bias and the postural impairment caused by the imbalanced otolith inputs after unilateral vestibular loss can be rapidly normalized by tilting the patients in the roll plane, an additional means in the physiotherapist’s toolbox. The protocol likely reweights the visual and somatosensory cues involved in the perception of verticality.
Whole-exome sequencing reveals Kawasaki disease susceptibility genes and their association with coronary artery lesion
Authors: Wang Yazhou , Chen Xuepeng , Zhang Dufei , Chen Renwei , Alifu Ailixiati 
Published: September 2024

ObjectiveThis study aimed to explore Kawasaki disease (KD) susceptibility genes and their complications like coronary artery lesions (CAL) using whole exome sequencing (WES).MethodsBetween April 1, 2021, and December 31, 2022, our study included 55 pediatric patients diagnosed KD at our center, alongside a cohort of healthy children who sought medical care at our institution during the same timeframe. We extracted peripheral blood DNA from all participants and employed the advanced high-throughput Illumina Next-Generation Sequencing technology for comprehensive analysis. Through bioinformatics evaluation, we identified potential susceptibility genes. Moreover, from the 55 KD patients, we selected 15 for the CAL group and 40 for the non-CAL group. We aimed to investigate whether there were significant differences in the allele frequencies of the targeted susceptibility genes between these subgroups, to explore the risk alleles associated with the development of CAL in KD.ResultsHLA-DRB1 rs17882084 and IL6ST rs781455079 genotypes and alleles differed significantly between KD and non-KD (P &lt; 0.05). No differences existed for IL17RC rs143781415 and VEGFB rs776229557 (P &gt; 0.05). No differences in HLA-DRB1 rs17882084, IL6ST rs781455079, and VEGFB rs776229557 genotypes existed between CAL and non-CAL groups (P &gt; 0.05). However, the IL17RC rs143781415 genotype differed significantly between them (P &lt; 0.05).ConclusionsHLA-DRB1 rs17882084 and IL6ST rs781455079 genotypes may be potential KD susceptibility gene candidates. Specifically, HLA-DRB1 rs17882084 GA genotype and A allele, and IL6ST rs781455079 TC genotype and C allele may increase KD risk. Additionally, the IL17RC rs143781415 genotype may increase CAL risk in KD patients.
Novel evidence of CNV deletion in KCTD13 related to the severity of isolated hypospadias in Chinese population
Authors: Chen Yijing , Zhou Lijun , Chen Fang , Chen Zhongzhong , Huang Yichen , Lv Yiqing , Wu Min , Lin Xiaoling , Xie Hua 
Published: September 2024

BackgroundCNV in KCTD13 has been identified to influence androgen receptor function via its changes in gene dosage, which might contribute to hypospadias. However, there is lack of population-level evidence to assess the contribution of KCTD13 CNV to hypospadias.Methods349 isolated hypospadias patients were recruited and their genotyping was performed using real-time qPCR. We use Database of Genomic Variants (DGV) and CNV calls from SNP-array intensity data in 1,008 Chinese healthy men as reference.Results11.17% of patients were identified to have KCTD13 CNV deletion, significantly higher than 0.05% in DGV (P &lt; 0.001), but no cases found to have CNV duplication. Meanwhile, no CNV calls encompassing KCTD13 region were detected in Chinese healthy men. Incidence of KCTD13 CNV deletion was significantly increased with the severity of hypospadias, P_trend = 9.00 × 10−6. Compared to distal hypospadias, ORs for the proximal and midshaft were 10.07 (2.91–34.84) and 6.08 (1.69–21.84) respectively. In addition, the association between genital characteristics (stretched penile length and glans width) and KCTD13 CNV showed no significance in hypospadias children (P &gt; 0.05).ConclusionsWe demonstrate KCTD13 CNV deletion is strongly associated with hypospadias and its severity, but duplication is not, characterizing KCTD13 genetic variation in more detail than previously described.
Potentially inappropriate prescribing in polymedicated older adults with atrial fibrillation and multimorbidity: a Swedish national register-based cohort study
Authors: Amrouch Cheima , Vetrano Davide Liborio , Damiano Cecilia , Dai Lu , Calderón-Larrañaga Amaia , Grymonprez Maxim , Proietti Marco , Lip Gregory Y. H. , Johnsen Søren P. , Wastesson Jonas W. , Johnell Kristina , De Smedt Delphine , Petrovic Mirko 
Published: September 2024

IntroductionCurrent research on potentially inappropriate prescribing (PIP) in polymedicated older adults with atrial fibrillation (AF) and multimorbidity is predominantly focused on PIP of oral anticoagulants (OAC). Our study aimed to assess (i) the overall prevalence of PIP in older multimorbid adults with AF, (ii) potential associated factors of PIP, and (iii) the association of PIP with adverse health outcomes in a nationwide sample of Swedish older adults.MethodsSwedish national registries were linked to establish a cohort with a 2-year follow-up of older adults (≥65y) who, on 1 January 2017, had a diagnosis of AF and had at least one comorbidity (n = 203,042). PIP was assessed using the reduced STOPP/START version 2 screening tool. The STOPP criteria identify potentially inappropriate prescribed medications (PIM), while the START criteria identify potential prescribing omissions (PPO). PIP is identified as having at least one PIM and/or PPO. Cox regression analyses were conducted to examine the association between PIP and adverse health outcomes: mortality, hospitalisation, stroke, bleeding, and falls.ResultsPIP was highly prevalent in older adults with AF, with both polypharmacy (69.6%) and excessive polypharmacy (85.9%). In the study population, benzodiazepines (22.9%), hypnotic Z-medications (17.8%) and analgesics (8.7%) were the most frequent PIM. Anticoagulants (34.3%), statins (11.1%), vitamin D and calcium (13.4%) were the most frequent PPO. Demographic factors and polypharmacy were associated with different PIM and PPO categories, with the nature of these associations differing based on the specific type of PIM and PPO. The co-occurrence of PIM and PPO, compared to appropriate prescribing, was associated with an increased risk of adverse health outcomes compared to all appropriately prescribed medications: cardiovascular (CV) (Hazard ratio (HR) [95% confidence interval] = 1.97 [1.88–2.07]) and overall mortality (HR = 2.09 [2.03–2.16]), CV (HR = 1.34 [1.30–1.37]) and overall hospitalisation (HR = 1.48 [1.46–1.51]), stroke (HR = 1.93 [1.78–2.10]), bleeding (HR = 1.10 [1.01–1.21]), and falls (HR = 1.63 [1.56–1.71]).ConclusionThe present study reports a high prevalence of PIP in multimorbid polymedicated older adults with AF. Additionally, a nuanced relationship between prescribing patterns, patient characteristics, and adverse health outcomes was observed. These findings emphasise the importance of implementing tailored interventions to optimise medication management in this patient population.
Burnout and moral injuries after foreign deployment among medical personnel of the German armed forces: a pre-post study
Authors: Langner Franziska , Börke Anna Katharina , Muschner Patric , Muther Maria , Reichelt Andreas , Willmund Gerd-Dieter , Wesemann Ulrich , Zimmermann Peter Lutz , Schönsee Isabel 
Published: September 2024

IntroductionGiven a high amount of workplace stressors, burnout syndrome, as a depression-related syndrome, is highly relevant for medical service soldiers. This study aims to examine their effects with regard to moral injuries and personal values following foreign deployment.Materials and methodsThis longitudinal study included 91 soldiers of the German Armed Forces Medical Service. Participants completed the Maslach Burnout Inventory (MBI) and the Portrait-Value-Questionnaire (PVQ) before and after a foreign deployment as well as the Moral Injury Scale (SMBE) after deployment. Analysis has been conducted using t-tests to assess potential changes in MBI and PVQ scales between pre-test - t1 (2-4 weeks before deployment) and post-test – t2 (up to 6 months after deployment). In addition, correlations were examined between moral injuries (MI) after deployment and MBI scores at t1 and t2 as well as between personal values (PVQ t1) and MBI scores at t1 and t2.ResultsThe MBI subscales showed mild to moderate burnout symptoms at both pre- and post-tests, with a slight deterioration during the study period, albeit not significant. There were no significant mean differences in PVQ between measurement points. Nevertheless, PVQ self-direction and tradition at t1 correlated negatively with MBI INV at t2 (PVQ SD r = -.21, p = .043) and MBI PA at t2 (PVQ TR r = -.23, p = .027). Furthermore, the subscale PVQ power at t1 correlated positively with MBI PA at t2 (PVQ PO r = .28, p = .006), meanwhile PVQ universalism at t1 correlated positively with MBI INV at t1 (PVQ UN r = .25, p = .018). Furthermore, positive correlations were found between moral injuries at t2 (SMBE total score, SMBE_Sub1, SMBE_Sub2) and MBI subscales Emotional Exhaustion (EE; r = -.54, p = .001), Depersonalization (DP; r = .38, p = .001), and Involvement (INV; r = .30, p = .004) before and after the deployment period. No correlation was found between MI and MBI subscale Personal Accomplishment (PA).ConclusionThe results indicate that medical service soldiers exhibit mild to moderate burnout symptoms even before deployment. Significant associations between moral injuries and burnout were found in 3 out of 4 MBI subscales (EE, DP, INV). There was a significant association with a stronger moral injury and higher burnout levels, persisting both before and after the study period. Furthermore, our results suggest that personal value orientations might be meaningful predictors of burnout. Hence, causal questions regarding general work stress among medical service soldiers should be further explored in more detailed studies. Further research could lay the foundation for future approaches in psychotherapy as well as primary and secondary prevention in this field.
The direct effects of media exposure on behaviors aimed at preventing COVID-19 and its indirect effects as mediated by interpersonal communication: a longitudinal study in Japan
Authors: Okada Hiroko , Okuhara Tsuyoshi , Kiuchi Takahiro 
Published: September 2024

ObjectiveWe aimed to examine the direct effects of exposure to media information about infection-preventing behavior and its indirect effects via interpersonal communication at two time points during the pandemic.MethodsIn August 2020 and August 2021, a web-based survey of Japanese people under a declared state of emergency was conducted. We collected sociodemographic data and data on seven types of exposure to media information, three types of exposure to interpersonal communication, and six types of infection-preventing behavior.ResultsA total of 784 participants completed both surveys. Exposure to information in the mass media decreased over the year, while interpersonal communication about COVID-19-related topics increased. The direct effect of exposure to information in the media about preventive behaviors was statistically significant in the pandemic’s early stages, but this was no longer true after 1 year. The indirect effect via interpersonal communication was statistically significant at both time points.ConclusionOur results suggest that the influence of media information on infection-preventing behavior during the pandemic was maintained over time as an indirect effect via interpersonal communication. For risk communication media strategies during pandemics, adopting strategies to generate interpersonal communication will have a sustained effect on preventive behavior.
Whitefly Detected: LED Traps Enhance Monitoring of Trialeurodes vaporariorum in Greenhouse-Grown Tomato
Authors: Grupe Björn , Meyhöfer Rainer 
Published: September 2024

Yellow sticky traps (YSTs) are common tools for monitoring the greenhouse whitefly (GWF), Trialeurodes vaporariorum Westwood (Hemiptera: Aleyrodidae), which can cause significant yield reduction in different greenhouse crops such as cucumber and tomato. In recent years, sticky traps equipped with green light-emitting diodes (LEDs) have also been (successfully) tested for catching GWFs. However, no study has observed GWF population dynamics at low population densities using such LED traps for early pest detection in crop stands. Therefore, a greenhouse experiment was conducted aiming to investigate the correlation between GWF populations on tomato crops (Solanum lycopersicum L. (Solanaceae)) and the numbers caught on yellow sticky traps and green LED traps, respectively. A small number of whiteflies was released into two pest-free greenhouse cabins, and populations on plants and traps were monitored for the duration of two months. The results show that the GWFs caught on LED traps correlate significantly positive with the population density on the tomato crops. Such a correlation was not found for standard YSTs. Moreover, the results indicate the possibility of early pest detection using LED traps. The findings are discussed in the context of the whiteflies’ ecology and population dynamics in greenhouses.
Encefalite de Rasmussen e seus desdobramentos: uma revisão bibliográfica
Authors: Souza Yuri Antonio de Melo , Andrade Isabela de Oliveira , Souza Rafaela Ferreira de 
Published: September 2024

Introdução: A encefalite de Rasmussen (RE)configura-se como uma encefalopatia inflamatória, possui a idade média de apresentação aos 6 anos, afetando principalmente crianças em desenvolvimento. Metodologia: Trabalho de revisão de literatura desenvolvido a partir de uma revisão bibliográfica baseada em estudos disponibilizados nas plataformas conceituadas: Pubmed, Lilacs e SciELO. Resultados e Discussão: A ER tem etiologia desconhecida, porém, estudos mais recentes classificam-na como uma doença imunomediada, caracterizada pelo envolvimento consistente de células T. A doença afeta normalmente crianças em desenvolvimento. A apresentação clínica da ER é assentada em dois aspetos: epilepsia e deterioração das funções neurológicas dependentes do hemisfério afetado. O tratamento da ER deve visar os sintomas, reduzindo a gravidade e frequência das crises de forma a melhorar o prognóstico de longo-prazo. Considerações finais: Devido a complexidade da etiologia, manejo e tratamento da ER, além do aumento do número de diagnósticos, ressalta-se a importância do conhecimento de tal síndrome para que os pacientes com ER possam ter uma vida relativamente normal.
Informatização de prontuários eletrônicos na atenção primária
Authors: Oliveira Maycon Denner Porcaro de , Silva Thávila dos Santos 
Published: September 2024

Este artigo pretende contribuir para o avanço tanto do processo de trabalho, quanto do processo avaliativo de serviços básicos em saúde, buscar entender como está distribuído o prontuário eletrônico em todo território nacional, comparar ambos os prontuários existentes, físico e digital e seus pontos negativos e positivos, com a intenção de melhorar os registros e ter uma melhor qualidade de informação que ajude na elaboração de novas políticas e programas de saúde, facilitando e auxiliando a rotina dos profissionais para melhor atender seus pacientes nas unidades de saúde. Métodos: realizado uma breve comparação entre os prontuários já existentes, enfatizando pontos positivos e negativos entre eles, elaborando uma revisão sobre o assunto, com o auxílio dos dados encontrados em artigos e teses na literatura, disponíveis em sites como: scielo, google acadêmico, biblioteca virtual online, site da Secretaria de Atenção Primária à Saúde, em painéis de indicadores, sobre a implantação desses serviços de informatização de prontuários eletrônicos no Brasil, delimitando a situação que se encontra esses avanços importantes em cada unidade federativa, para discorremos do quanto já está difundido na sociedade essa ferramenta. Resultados: obteve-se que, ainda se encontram desafios acerca da implementação dessa ferramenta no território nacional, sobretudo nas regiões menos desenvolvidas economicamente, como Norte e Nordeste, atrás de regiões mais desenvolvidas, como região centro-oeste, sul e sudeste, pois o acesso à essa tecnologia demanda um grande investimento financeiro. Conclusão: a informatização nas unidades básicas de saúde é um desafio, o qual pode ser superado com planejamento eficiente, investimento financeiro, educação digital e comprometimento das equipes que desempenharam a prática do prontuário eletrônico do paciente.