bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of human resource capital information disclosure on investors’ share investment intentions
Authors: Mariappanadar Sugumar , Kairouz Alma 
Published: March 2017

PurposeThe purpose of this paper is to apply the strategic human resource management (HRM) perspective to investigate the schematic relationship between the dimensions of human resource (HR) capital information and intentions to use such information in individual investors’ decisions relating to investing equities in the banking industry.Design/methodology/approachA two-stage empirical study was conducted in 2010 using a four-part HR capital disclosure questionnaire, which was developed and validated in stage 1 (n=145) of the study. In stage 2 (n=157), current or previous shareholders in one of the Australian banking sector corporations participated in the study. The collected data were analyzed using confirmatory factor and logistic regression analyses.FindingsThe findings of this explorative study highlight that the individual investors’ perception on the importance of performance management dimension of HR capital information has varied impacts on their intentions to use such information in investment decisions to buy, hold on to, or sell stocks.Practical implicationsThis study has made an important contribution to the strategic HRM and behavioral finance literature that the human capital information facilitates the propensity to avoid regrets in selling shares too early (dispositional effect bias) to achieve utility benefits in future which is different from the findings of financial information disclosure study.Originality/valueA recent critical review of HR disclosure indicated that most of the published articles on HR capital have used company annual reports for data source. However, this is the first study that attempts to understand the impact of HR capital disclosure information on investment intentions from individual investors’ schema rather than drawing data from company annual reports.
Air pollution and short‐term clinical outcomes of patients with acute myocardial infarction
Authors: Lee Min Woo , Choi Byoung Geol , Kim Suhng Wook , Rha Seung‐Woon , Shim Min Suk , Kim Dae Jin , Seo Hong Seog , Oh Dong Joo , Jeong Myung ho ,   Other Korea Acute Myocardial Infarction Registry (KAMIR) investigators
Published: March 2017

SummaryAmbient air pollution is well‐known to be a serious risk factor for cardiovascular diseases, stroke, and death. However, the association between air pollutants (AP) exposure and short‐term clinical outcomes in acute myocardial infarction (AMI) patients (pts) has not been elucidated well. In the present study, 37 880 AMI pts were enrolled from October 2005 to December 2013 in a nationwide large‐scale, prospective, multicentre Korea AMI registry (KAMIR registry; http://www.kamir.or.kr). We obtained data on AP (e.g., NO2, SO2, CO, O3 and PM10) from the Korean National Institute of Environmental Research (NIER; http://www.nier.go.kr). Clinical endpoints included death, recurrent myocardial infarction (Re‐MI), any revascularization and composite of all‐cause death and Re‐MI. Exposure to AP is defined as the average exposure to AP within 24 hours before AMI admission. We observed that a 0.01 part per million (ppm) increase in NO2 concentration, 0.001 ppm increase in SO2 concentration, and 0.1 ppm increase in CO concentration each increased the risk of total death by 9.7% (95% CI, 6.2%‐13.4%), 1.9% (95% CI, 0.3%‐3.6%), and 2.1% (95% CI, 0.5%‐3.9%), respectively. Exceptionally, O3 decreased the risk of total death by 0.6% (95% CI −0.2% to −1.0%) per 0.01 ppm increase. PM10 was not related to any cardiovascular events. AP were each stratified into five quintiles according to ranges of AP levels. After adjusting analysis for risk variables, only high quintiles (Q4, Q5) of NO2 were positively associated with total death, cardiac death and MI, while SO2, CO, O3 and PM10 were shown to be not related to any cardiovascular events at all levels. In AMI patients, each AP and its concentration has shown a different effect to short‐term mortality and cardiovascular events.
Amplification of FSH signalling by CFTR and nuclear soluble adenylyl cyclase in the ovary
Authors: Chen Hui , Chan Hsiao Chang 
Published: March 2017

SummaryThe cAMP/PKA pathway is one of the most important signalling pathways widely distributed in most eukaryotic cells. The activation of the canonical cAMP/PKA pathway depends on transmembrane adenylyl cyclase (tmAC). Recently, soluble adenylyl cyclase (sAC), which is activated by HCO3− or Ca2+, emerges to provide an alternative way to activate cAMP/PKA pathway with the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP‐activated Cl−/HCO3−‐conducting anion channel, as a key player. This review summarizes new progress in the investigation of the CFTR/HCO3−‐dependent sAC signalling and its essential role in various reproductive processes, particularly in ovarian functions. We present the evidence for a CFTR/HCO3−‐dependent nuclear sAC signalling cascade that amplifies the FSH‐stimulated cAMP/PKA pathway, traditionally thought to involve tmAC, in granulosa for the regulation of oestrogen production and granulosa cell proliferation. The implication of the CFTR/HCO3−/sAC pathway in amplifying other receptor‐activated cAMP/PKA signalling in a wide variety of cell types and pathophysiological processes, including aging, is also discussed.
Geographic Disparities in Availability of Opioid Use Disorder Treatment for Medicaid Enrollees
Authors: Abraham Amanda J. , Andrews Christina M. , Yingling Marissa E. , Shannon Jerry 
Published: March 2017

ObjectiveTo examine county‐level geographic variation in treatment admissions among opioid treatment programs (OTPs) that accept Medicaid in the continental United States.Data Sources/Study SettingData come from the 2012 National Survey of Substance Abuse Treatment Services.Study Design/Data CollectionWe used local measures of spatial autocorrelation (LISA) analysis to identify (1) clusters of counties with higher and lower than average rates of opioid use disorders and (2) clusters of counties with higher and lower than average treatment admissions among OTPs that accept Medicaid, adjusting for county population size.Principal FindingsOur results reveal several clusters of counties with higher than average rates of opioid use disorder (OUD) and lower than average treatment admissions among OTPs that accept Medicaid. These clusters are highly concentrated in the Southeast region of the country and include Arkansas, Kentucky, Louisiana, Mississippi, and Tennessee.ConclusionsMedicaid enrollees in areas in the Southeast have the largest gaps between county‐level OUD rates and estimated county‐level capacity for treatment, as measured by county‐level total treatment admissions among OTPs that accept Medicaid. Policy makers should consider strategies to increase the availability of OTPs with the capacity to serve Medicaid enrollees.
Adapting Evaluations of Alternative Payment Models to a Changing Environment
Authors: Grannemann Thomas W. , Brown Randall S. 
Published: March 2017

ObjectiveTo identify the most robust methods for evaluating alternative payment models (APMs) in the emerging health care delivery system environment.Study Design (Approach)We assess the impact of widespread testing of alternative payment models on the ability to find credible comparison groups. We consider the applicability of factorial research designs for assessing the effects of these models.Principal FindingsThe widespread adoption of alternative payment models could effectively eliminate the possibility of comparing APM results with a “pure” control or comparison group unaffected by other interventions. In this new environment, factorial experiments have distinct advantages over the single‐model experimental or quasi‐experimental designs that have been the mainstay of recent tests of Medicare payment and delivery models.ConclusionsThe best prospects for producing definitive evidence of the effects of payment incentives for APMs include fractional factorial experiments that systematically vary requirements and payment provisions within a payment model.
Physician Competition in the Era of Accountable Care Organizations
Authors: Richards Michael R. , Smith Catherine T. , Graves Amy J. , Buntin Melinda B. , Resnick Matthew J. 
Published: March 2017

ObjectiveTo calculate physician concentration levels for all U.S. markets using detailed data on integration and accountable care organization (ACO) participation.Data Source2015 SK&A office‐based physician survey linked to all commercial and public payer ACOs.Study DesignWe construct three separate Herfindahl–Hirschman Index (HHI) measures and plot their distributions. We then investigate how prevailing levels of concentration change when incorporating more detailed organizational features into the HHI measure.Principal FindingsHorizontal and vertical integration strongly influences measures of physician concentration; however, ACOs have limited impact overall. ACOs are often present in competitive markets, and only in a minority of these markets do ACOs substantively increase physician concentration.ConclusionsMonitoring ACO effects on physician competition will likely have to proceed on a case‐by‐case basis.
Effects of Catechins and Their Related Compounds on Cellular Accumulation and Efflux Transport of Mitoxantrone in Caco‐2 Cell Monolayers
Authors: Sugihara Narumi , Kuroda Norihiko , Watanabe Fumiya , Choshi Tominari , Kamishikiryo Jun , Seo Makoto 
Published: March 2017

AbstractThe ability of catechins and their related compounds to inhibit breast cancer resistance protein (BCRP) function in Caco‐2 cell monolayers was investigated with mitoxantrone as a BCRP substrate. The gallate or pyrogallol moiety on the catechin structure seemed to promote increased cellular accumulation and inhibit efflux transport of mitoxantrone. The ability of gallate catechins such as (−)‐epigallocatechin gallate (EGCG) and (−)‐epicatechin gallate (ECG) to increase cellular accumulation and inhibit efflux transport of mitoxantrone was greater than that of nongallate catechins. Gallic acid octyl ester (GAO) also increased intracellular mitoxantrone accumulation. Experiments using GAO derivatives indicated that the gallate moiety required the presence of a long carbon chain for BCRP inhibition. Cellular accumulation and reduced efflux transport of mitoxantrone were greater with epigallocatechin 3‐(3″‐O‐butyl) gallate than with EGCG. EGCG inhibition of BCRP seemed to be restricted by hydrophobicity. The co‐administration of catechins, particularly EGCG and related compounds, with greater hydrophobicity may increase the therapeutic activities of BCRP substrates such as mitoxantrone.
Primary intestinal lymphangiectasia: Multiple detector computed tomography findings after direct lymphangiography
Authors: Sun Xiaoli , Shen Wenbin , Chen Xiaobai , Wen Tingguo , Duan Yongli , Wang Rengui 
Published: March 2017

AbstractIntroductionTo analyse the findings of multiple detector computed tomography (MDCT) after direct lymphangiography in primary intestinal lymphangiectasia (PIL).MethodsFifty‐five patients with PIL were retrospectively reviewed. All patients underwent MDCT after direct lymphangiography. The pathologies of 16 patients were confirmed by surgery and the remaining 39 patients were confirmed by gastroendoscopy and/or capsule endoscopy.ResultsAfter direct lymphangiography, MDCT found intra‐ and extraintestinal as well as lymphatic vessel abnormalities. Among the intra‐ and extraintestinal disorders, 49 patients had varying degrees of intestinal dilatation, 46 had small bowel wall thickening, 9 had pleural and pericardial effusions, 21 had ascites, 41 had mesenteric oedema, 20 had mesenteric nodules and 9 had abdominal lymphatic cysts. Features of lymphatic vessel abnormalities included intestinal trunk reflux (43.6%, n = 24), lumbar trunk reflux (89.1%, n = 49), pleural and pulmonary lymph reflux (14.5%, n = 8), pericardial and mediastinal lymph reflux (16.4%, n = 9), mediastinal and pulmonary lymph reflux (18.2%, n = 10), and thoracic duct outlet obstruction (90.9%, n = 50).ConclusionsMultiple detector computed tomography after direct lymphangiography provides a safe and accurate examination method and is an excellent tool for the diagnosis of PIL.
Overall evaluability of low dose protocol for computed tomography angiography of thoracic aorta using 80 kV and iterative reconstruction algorithm using different concentration contrast media
Authors: Annoni Andrea Daniele , Mancini Maria E , Andreini Daniele , Formenti Alberto , Mushtaq Saima , Nobili Enrica , Guglielmo Marco , Baggiano Andrea , Conte Edoardo , Pepi Mauro 
Published: March 2017

AbstractIntroductionMultidetector Computed Tomography Angiography (MDCTA) is presently the imaging modality of choice for aortic disease. However, the effective radiation dose and the risk related to the use of contrast agents associated with MDCTA is an issue of concern. Aim of this study was to assess image quality of a low dose ECG‐gated MDCTA of thoracic aorta using different concentration contrast media without tailored injection protocol.MethodsTwo‐hundred patients were randomised into four different scan protocols: Group A (Iodixanol 320 and 80 Kvp tube voltage), Group B (Iodixanol 320 and 100 Kvp tube voltage), Group C (Iomeprol 400 and 80 Kvp tube voltage) and Group D (Iomeprol 400 and 100 Kvp tube voltage). Image quality, noise, signal‐to‐noise ratio (SNR), contrast‐to‐noise ratio (CNR) and effective dose (ED) were compared among groups.ResultsNo significant differences in image noise, SNR and CNR between groups with the same tube voltage. Significant differences in SNR and CNR were found among groups with 80 kV versus groups using 100 kV but without differences in terms of image quality. ED was significantly lower in groups with 80 kV.ConclusionsMultidetector Computed Tomography Angiography protocols using 80 kV and low concentration contrast media are feasible without need of tailored injection protocols.
Effects of T‐loop modification on the PII‐signalling protein: structure of uridylylated Escherichia coli GlnB bound to ATP
Authors: Palanca Carles , Rubio Vicente 
Published: March 2017

SummaryTo adapt to environments with variable nitrogen sources and richness, the widely distributed homotrimeric PII signalling proteins bind their allosteric effectors ADP/ATP/2‐oxoglutarate, and experience nitrogen‐sensitive uridylylation of their flexible T‐loops at Tyr51, regulating their interactions with effector proteins. To clarify whether uridylylation triggers a given T‐loop conformation, we determined the crystal structure of the classical paradigm of PII protein, Escherichia coli GlnB (EcGlnB), in fully uridylylated form (EcGlnB‐UMP3). This is the first structure of a postranslationally modified PII protein. This required recombinant production and purification of the uridylylating enzyme GlnD and its use for full uridylylation of large amounts of recombinantly produced pure EcGlnB. Unlike crystalline non‐uridylylated EcGlnB, in which T‐loops are fixed, uridylylation rendered the T‐loop highly mobile because of loss of contacts mediated by Tyr51, with concomitant abolition of T‐loop anchoring via Arg38 on the ATP site. This site was occupied by ATP, providing the first, long‐sought snapshot of the EcGlnB‐ATP complex, connecting ATP binding with T‐loop changes. Inferences are made on the mechanisms of PII selectivity for ATP and of PII‐UMP3 signalling, proposing a model for the architecture of the complex of EcGlnB‐UMP3 with the uridylylation‐sensitive PII target ATase (which adenylylates/deadenylylates glutamine synthetase [GS]) and with GS.
Screening for malnutrition in hospitalised older people: Comparison of the Mini Nutritional Assessment with its short‐form versions
Authors: Dent Elsa , Chapman Ian , Piantadosi Cynthia , Visvanathan Renuka 
Published: March 2017

ObjectiveTo determine how well the Mini Nutritional Assessment (MNA) Short Form (MNA‐SF) performed as a nutritional screening tool when calf circumference replaced body mass index (BMI) as the included anthropometric measurement.MethodsA total of 100 patients ≥70 years were recruited from a Geriatric Evaluation and Management Unit.ResultsMean age of patients was 85.2 (6.1) years. By the full MNA, 40% of patients were malnourished. The MNA correlated highly with both of its short‐form versions (r = 0.87 and r = 0.90 for the BMI and calf circumference versions, respectively). Both MNA‐SF versions also showed high accuracy in identifying malnutrition (auROC values >0.89).ConclusionsThe MNA‐SF is a rapid and accurate way to screen for malnutrition in hospitalised older adults. Substitution of BMI measurement with the time‐efficient calf circumference measurement maintained MNA‐SF accuracy. It is recommended that calf circumference measurement be used for nutritional screening by MNA‐SF in a hospital setting.
Neospora caninumin beef herds in New South Wales, Australia. 2: analysis of risk factors
Authors: Moloney BJ , Heuer C , Kirkland PD 
Published: March 2017

ObjectiveTo determine the influence of farm‐level and animal‐level factors on the seroprevalence of antibodies toNeospora caninumand associations between seropositivity and reproductive outcomes.MethodsA questionnaire for a cross‐sectional survey was posted to the 63 properties with a herd size ≥50 beef breeding cows that had participated in a previous seroprevalence study. Correspondence analysis, which does not appear to have been used previously in any Australian studies of livestock diseases, was used in conjunction with logistic regression to analyse the data.ResultsGeographic factors that increased the risk of seropositivity included higher rainfall North Coast location. Herd management factors that increased the risk of seropositivity included the use ofBos indicusgenetics, cross‐breeding and running several breeds in the one herd. Using fox control measures was found to be protective against infection withN. caninum. The risk of abortion was 12‐fold greater in individual animals that were seropositive forN. caninum.Within a herd, the calving rate was 10.4% lower in herds with one or moreN. caninum‐positive animals (P = 0.03), but the difference in abortion rate was not significant between seropositive and seronegative herds (0.3% higher, P > 0.3).ConclusionsThis study confirmed previous observations of increased risks forN. caninumseropositivity with being located in the coastal subtropics, some styles of herd management and canid exposure. In addition, it suggested that cross‐breeding and proximity to an urban area may increase the risk, and that having pet dogs may reduce the risk of seropositivity.
Congenital bilateral anterior nasal atresia in 16 half‐sibling Holstein‐Friesian calves
Authors: McGowan M , Smith C , Ferguson A , Stone B , Vankan D , Allavena R 
Published: March 2017

Case reportCases of bilateral anterior nasal atresia, sometimes referred to as arhinia or partial arhinia, are extremely rare in cattle and have only been reported as single events. This report describes the birth of 16 Holstein Friesian calves over a 3‐month period, all affected with bilateral atresia of the nares and anterior nasal cavity, with 2 calves having additional severe deviation of the nasomaxillary bones and nasal septum. One affected calf was born with an anatomically normal twin. Parentage testing demonstrated that a single Holstein Friesian bull sired all cases tested.ConclusionThis is the first report of multiple cases of bilateral anterior nasal atresia in cattle with evidence that demonstrates a heritable condition.
Pharmacokinetics and safety of letermovir, a novel anti‐human cytomegalovirus drug, in patients with renal impairment
Authors: Kropeit Dirk , Scheuenpflug Jürgen , Erb‐Zohar Katharina , Halabi Atef , Stobernack Hans‐Peter , Hulskotte Ellen G. J. , van Schanke Arne , Zimmermann Holger , Rübsamen‐Schaeff Helga 
Published: March 2017

AimsHuman cytomegalovirus remains a significant issue for immunocompromised patients and existing viral polymerase targeting therapies are associated with significant toxicity. Accordingly, the viral terminase complex inhibitor, letermovir, is in development. We assessed letermovir pharmacokinetics in renal impairment.MethodsThis was a Phase 1, open‐label, nonrandomised trial. Estimated glomerular filtration rate based on the Modification of Diet Renal Disease equation was used to create three groups of eight subjects: healthy function (estimated glomerular filtration rate ≥ 90 ml min–1 1.73m–2), moderate (30–59 ml min–1 1.73m–2) and severe (<30 ml min–1 1.73m–2) impairment. Oral letermovir 120 mg was dosed once‐daily for 8 days and blood collected for pharmacokinetic analyses.ResultsAll 24 subjects enrolled completed the trial. Moderate and severe renal impairment increased mean unbound letermovir fractions by 11% and 26%, respectively, vs. healthy subjects. Exposure (AUCτ,ss and Css,max) was increased with renal impairment [least square mean ratios (90% confidence intervals) total letermovir vs. healthy subjects, AUCτ,ss 192% (143–258%) and 142% (83–243%) for moderate and severe impairment, respectively; Css,max 125% (87–182%) and 106% (75–151%), respectively]. Clearance was decreased vs. healthy subjects. Correlation analyses indicated a correlation between decreasing renal function and increased unbound letermovir concentration (R2 = 0.5076, P < 0.0001). Correlations were identified between decreased clearance with both decreased renal function (R2 = 0.0662, P = 0.2249 and R2 = 0.1861, P = 0.0353 total and unbound clearance, respectively) and increased age (R2 = 0.3548, P = 0.0021 and R2 = 0.3166, P = 0.0042 total and unbound clearance, respectively). Multiple‐dose letermovir 120 mg was well tolerated across groups.ConclusionsRenal impairment increased exposure to letermovir, although age was a confounding factor.