bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of survivals between sublobar resection and lobar resection for patients with clinical stage I non‐small cell lung cancer and interstitial lung disease: a propensity score matching analysis
Authors: Matsushima Ryohei , Fujino Kosuke , Motooka Yamato , Yamada Hiroyuki , Shirakami Chika , Shinchi Yusuke , Osumi Hironobu , Yamada Tatsuya , Yoshimoto Kentaro , Ikeda Koei , Kubota Ichiro , Suzuki Makoto 
Published: September 2024

AbstractBackgroundPatients with early‐stage lung cancer and interstitial lung disease have a poorer prognosis than those without interstitial lung disease. This study aimed to compare the long‐term outcomes of lobar and sublobar resections in these patients.MethodsWe retrospectively analyzed 138 consecutive patients with clinical stage I non‐small cell lung cancer and interstitial lung disease who underwent surgical treatment at two institutions between January 2010 and December 2020. Propensity score matching analysis was performed to adjust for baseline characteristics.ResultsThirty‐six patients underwent sublobar resection and 102 underwent lobar resection. The median follow‐up was 45.7 months. In all patients, 5‐year overall survival (OS) rates were 33.2% and 73.2%, and 5‐year recurrence‐free survival (RFS) rates were 24.2% and 60.1% in the sublobar and lobar resection groups, respectively (p < 0.01, <0.01). Death due to lung cancer and locoregional recurrence were significantly more frequent in the sublobar resection group than in the lobar resection group (p = 0.034, <0.01, respectively). On propensity score matching analysis, the 5‐year OS rates of the 19 matched pairs were 46.3% and 73.2%, and the RFS rates were 31.6% and 67.6% in the sublobar and lobar resection groups, respectively (p = 0.036, <0.01). The Cox proportional hazards model demonstrated a significant association between lobar resection and improved survival (p = 0.047).ConclusionThe patients in the lobar resection group had better survival rates than those in the sublobar resection group. In terms of long‐term prognosis, deliberately limited surgery may not be necessary for patients who tolerate lobectomy.
Clinical manifestation and outcome of lung cancer patients with ocular metastasis: 16 case reports and systematic review
Authors: Liu Yunxin , Feng Xiaoyi , Xu Yan , Yu Siyuan , Wang Mengzhao 
Published: September 2024

AbstractOcular metastasis is a rare type of distant metastasis of lung cancer. Limited information is available regarding ocular symptoms, diagnosis, treatment, and prognosis. We reported 16 patients diagnosed with ocular metastasis from lung cancer treated at our hospital from January 1988 to March 2024 and conducted a systematic review of 100 patients retrieved from the PubMed database from January 2014 to December 2023. A pooled analysis was performed using individual‐level patient data to generate the hazard ratio (HR) of the association between patient characteristics and overall survival. A total of 116 patients, 100 patients from the literature and 16 patients from our center, diagnosed with ocular metastasis from lung cancer were included in this study. Choroid metastasis was presented in 77 (66.4%) patients and was significantly associated with the onset of lung cancer with ocular symptoms and decreased vision; iris metastasis was significantly associated with small cell lung cancer (SCLC), high intraocular pressure, and ocular pain. Multivariate analyses revealed that males (HR, 2.488; 95% confidence interval [CI], 1.127–5.495), age ≥ 60 years (HR, 3.196; 95% CI, 1.391–7.341), and onset with ocular symptoms (HR, 4.312; 95% CI, 1.675–11.099) were significantly associated with overall survival. For non‐SCLC (NSCLC) patients, compared with chemotherapy, targeted therapy (HR, 0.238; 95% CI, 0.087–0.651) and combined therapy (HR, 0.133; 95% CI, 0.017–0.822) have greater therapeutic efficacy. Chemotherapy combined with immunotherapy and targeted therapy are more effective than chemotherapy alone for ocular metastatic NSCLC patients. For patients with targetable mutations, new‐generation tyrosine kinase inhibitors (TKIs) are preferred.
Long guidewire peripheral intravenous catheters in emergency departments for management of difficult intravenous access: A multicenter, pragmatic, randomized controlled trial
Authors: Xu Hui (Grace) , Corley Amanda , Young Emily R. , Doubrovsky Anna , Ware Robert S. , Afoakwah Clifford , Wang Carrie , Stirling Scott , Marsh Nicole 
Published: September 2024

AbstractBackgroundA quarter of patients who present to emergency departments (EDs) have difficult intravenous access (DIVA), making it challenging for clinicians to successfully place a peripheral intravenous catheter (PIVC). Some literature suggests that guidewire PIVC improves first‐insertion success rate.AimThe aim was to determine the clinical and cost‐effectiveness of a novel long PIVC (5.8 cm) with a retractable coiled guidewire (GW‐PIVC) for patients with DIVA, compared with standard care PIVCs.MethodsA pragmatic randomized controlled trial was conducted in two Australian EDs. Eligible participants were adults assessed as meeting DIVA criteria. Participants were randomized (1:1 ratio; stratified by hospital) to either GW‐PIVC (long) or standard care group (short or long PIVC). The use of ultrasound was discretionary in the standard care group and was recommended in the GW‐PIVC group due to the pragmatic design that was primarily testing the GW‐PIVC rather than the ultrasound use. Primary outcome was first‐insertion success and secondary outcomes included all‐cause device failure, patient and staff satisfaction, and cost‐effectiveness. The analysis was intention to treat.ResultsA total of 446 participants were randomized and 409 received PIVCs. The use of GW‐PIVC, compared with standard PIVC, had a lower first‐insertion success rate (68% vs. 77%, odds ratio [OR] 0.65, 95% confidence interval [CI] 0.43–0.99, p < 0.05). There was no difference in PIVC failure (134.0 per 1000 catheter days [GW‐PIVC] vs. 111.8 [standard PIVC] per 1000 catheter days, hazard ratio 1.18, 95% CI 0.72–1.95). Both participant (8/10 vs. 9/10, median difference [MD] −1.00, 95% CI −1.37 to −0.63) and clinician (8/10 vs. 10/10, MD −2.00, 95% CI −2.37 to −1.63) satisfaction was lower with GW‐PIVCs compared with standard PIVCs. More nurses inserted standard PIVCs than GW‐PIVCs (56.9% vs. 36.5%) and had less confidence in their ultrasound skills (28.0% vs. 46.6% self‐claimed as advanced/expert users). The cost per participant of GW‐PIVC insertions was 2.46 times greater than standard PIVC insertions ($AU80.24 vs. $AU32.57).ConclusionsGW‐PIVCs had significantly lower first‐insertion success and non–significantly higher all‐cause catheter failure. Additional training and device design familiar to clinicians are vital factors to enhance the likelihood of successful future implementation of GW‐PIVCs.
The influence of upward social comparison on status consumption in clothing, eating, living, and travelling: The mediating effects of perceived self‐improvement and perceived superiority
Authors: Liang Geying , Li Yan , Song Wu , Wang Yiwen 
Published: September 2024

AbstractCompensatory consumption theory posits that individuals tend to engage in status consumption as a response to experiencing upward social comparison. However, it is unclear whether upward social comparison can influence status consumption in four lifestyle domains: clothing, eating, living, and travelling. Therefore, we conducted two separate studies with a sample of Chinese consumers. In Study 1, we investigated the effects of upward social comparison on status consumption in four domains by comparing participants with a specific individual. In Study 2, we examined the effects of upward social comparison on status consumption in four domains by comparing participants with a group. Additionally, Study 2 examined the mediating role of perceived self‐improvement and perceived superiority. The results revealed that participants exhibited higher purchase intentions and preferences for status products and services in four consumption domains when exposed to upward social comparison. Furthermore, the results also indicated that perceived self‐improvement and perceived superiority mediated the positive effects of status consumption in four domains under upward social comparison. These findings contribute to the broader applicability of compensatory consumption theory.
Letter: Social work and clinical synergy—Optimising health interventions for elderly DGBI populations
Authors: Zhang Rui , Wei Hua , Liu Ming 
Published: September 2024

LINKED CONTENTThis article is linked to Sperber et al papers. To view these articles, visit https://doi.org/10.1111/apt.18103 and https://doi.org/10.1111/apt.18252
Letter: Social work and clinical synergy—Optimizing health interventions for elderly DGBI populations: Authors' reply
Authors: Sperber Ami D. , Freud Tamar , Palsson Olafur S. , Bangdiwala Shrikant I. , Simren Magnus 
Published: September 2024

LINKED CONTENTThis article is linked to Sperber et al papers. To view these articles, visit https://doi.org/10.1111/apt.18103 and https://doi.org/10.1111/apt.18225
Associations between negative sexual messaging in childhood and sex guilt in adulthood
Authors: Yang T. Ariel , Dolan Abby , Hernandez Valeria , Kaufman Ava , Kruk Mary , Robbins Katherine , Conley Terri D. 
Published: September 2024

AbstractSex guilt refers to a feeling of shame or anxiety induced by sexual behavior due to the inconsistency between a person's value and their sexuality. Sex guilt often stems from traditional, gender stereotypical sexual views and attitudes. In this study, we inquired what factors could be predicting sex guilt. Negative sexual messaging (NSM) refers to the promotion of abstinence and the glorification of virginity, representing a set of sex‐negatives views. We evaluated the relationships between NSM in childhood and sex guilt in adulthood. We include childhood sexual abuse as an alternative predictor of sex guilt to anchor our results with NSM. Participants were recruited through undergraduate groups and online platforms (total N = 1322) and completed an online survey regarding about their sexual experience. We found that NSM was a strong, persistent predictor of sex guilt. Those who experienced more NSM reported higher sex guilt. Our findings could be particularly informative for educators and policy maker who creates sex education curricula. Further study is needed to clarify the mechanisms through which NSM are associated with sex guilt.
A novel single‐port robotic proximal gastrectomy with right‐sided overlap and single‐flap valvuloplasty (RPG‐ROSF) to treat gastroesophageal cancer: A case report
Authors: Tou Laizhen , Jiang Chuan , Wu Dan , Zheng Jingjing , Luo Desheng , Que Haifeng , Sun Zheng , Wang Chuanguang , Wang Yue , Tao Xudong , Wang Jiaxun , Li Chengchang , Li Shuling , Zhu Xiaoxiao , Xu Hongtao 
Published: September 2024

AbstractRobotic surgery has been widely used in surgical gastric cancer treatments, including proximal gastrectomy. Single‐port robotic system is gaining more popularity in robotic surgery, but there has been no report on its application in robotic proximal gastrectomy with right‐sided overlap and single‐flap valvuloplasty (RPG‐ROSF). Here, we report an RPG‐ROSF using a novel single‐port robotic system in a 51‐year‐old male patient with an early‐stage gastroesophageal cancer detected by gastroscopy. It took 90 min for robotic setup, 143 min for dissection, and 161 min for digestive tract reconstruction. There was no complication during and after the surgery. The patient was discharged in 8 days postsurgery. The pathological staging of the adenocarcinoma was pT1aN0M0. This preliminary study demonstrated the feasibility and safety of a novel single‐port robot in RPG‐ROSF.
Clinical characteristics and risk factors for antituberculosis drug‐induced hypersensitivity
Authors: Liu Quanxian , Guo Dingtao , Yu Mei , Tang Daoyan , Zhang Yongxian , Luo Mei , He Jianqing 
Published: September 2024

AbstractAimsThe aim of this study was to explore the clinical characteristics and risk factors for hypersensitivity reactions induced by antituberculosis drugs.MethodsA retrospective analysis was conducted on the medical records of patients with active tuberculosis (TB) treated in the TB ward at West China Hospital, Sichuan University, from November 2010 to April 2020.ResultsOut of 7106 patients with active tuberculosis, 205 experienced hypersensitivity reactions to antituberculosis drugs; the incidence of hypersensitivity was 2.9%. The predominant clinical manifestation was a rash, observed in 57.1% (117/205) of these cases. Additionally, 19.0% (39/205) of patients presented with concurrent liver injury. The laboratory parameters white blood cell count, total lymphocyte count, monocyte count, eosinophil count, basophil count, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase were significantly elevated in patients with hypersensitivity compared to those without. In 38 patients who tested positive for oral antituberculosis drug provocation, 14 (36.8%) were allergic to more than two antituberculosis drugs. Significant risk factors included being female (odds ratio [OR] = 1.387, 95% confidence intervals [CI]: 1.016–1.894), under 65 years of age (OR = 1.826, 95% CI: 1.145–2.913), existing liver disease (OR = 2.464, 95% CI: 1.822–3.333) and a history of allergic diseases (OR = 6.633, 95% CI: 2.681–16.406) and were significantly correlated with hypersensitivity to antituberculosis drugs.ConclusionsHypersensitivity reactions to antituberculosis drugs primarily affect the skin, with significant associations observed with liver injury. Females, individuals younger than 65 years, those with pre‐existing liver disease and patients with a history of allergic diseases are at elevated risk for hypersensitivity.
Incidence of new fractures in older patients with osteoporosis receiving biosimilar teriparatide or reference products: A retrospective cohort study
Authors: Sato So , Sasabuchi Yusuke , Okada Akira , Yasunaga Hideo 
Published: September 2024

AimsBiosimilar products have clinical characteristics similar to those of brand‐name products and can reduce medical costs. However, the use of biosimilar products for osteoporosis treatments remains limited due to concerns regarding its safety and efficacy. We aimed to clarify the effectiveness and safety of the biosimilar teriparatide compared with those of the reference product using the incidence of new fractures and osteosarcoma as outcomes in osteoporosis patients.MethodsThis study used the DeSC database, which contains medical claims data for various insurers in Japan. We included patients with osteoporosis aged ≥65 years who newly received either biosimilar teriparatide or the reference products between April 2019 and November 2022. Competing risk analyses were performed with adjustments for patient characteristics. The primary and secondary outcomes were the occurrence of new fractures and osteosarcoma, respectively.ResultsAmong 45 861 included patients, 3613 and 42 248 were in the biosimilar and reference product groups, respectively. The median follow‐up duration was 439 days. New fractures occurred in 6.7% of patients. Cumulative incidence function curves showed similar risks of new fractures over time in both groups. The cause‐specific hazard ratio for new fractures was 0.95 (95% confidence interval: 0.82–1.11) for the biosimilar group compared with that of the reference product group. The incidence of osteosarcoma did not differ significantly between the groups (P = .559).ConclusionsThe biosimilar teriparatide showed effectiveness and safety comparable with those of the reference products in treating osteoporosis patients. Our results suggest that clinicians need not hesitate to prescribe biosimilar teriparatide for osteoporosis patients.
Ecological interactions in glacier environments: a review of studies on a model Alpine glacier
Authors: Crosta Arianna , Valle Barbara , Caccianiga Marco , Gobbi Mauro , Ficetola Francesco Gentile , Pittino Francesca , Franzetti Andrea , Azzoni Roberto Sergio , Lencioni Valeria , Senese Antonella , Corlatti Luca , Buda Jakub , Poniecka Ewa , Novotná Jaroměřská Tereza , Zawierucha Krzysztof , Ambrosini Roberto 
Published: September 2024

ABSTRACTGlaciers host a variety of cold‐adapted taxa, many of which have not yet been described. Interactions among glacier organisms are even less clear. Understanding ecological interactions is crucial to unravelling the functioning of glacier ecosystems, particularly in light of current glacier retreat. Through a review of the existing literature, we aim to provide a first overview of the biodiversity, primary production, trophic networks, and matter flow of a glacier ecosystem. We use the Forni Glacier (Central Italian Alps) – one of the best studied alpine glaciers in the world – as a model system for our literature review and integrate additional original data. We reveal the importance of allochthonous organic matter inputs, of Cyanobacteria and eukaryotic green algae in primary production, and the key role of springtails (Vertagopus glacialis) on the glacier surface in sustaining populations of two apex terrestrial predators: Nebria castanea (Coleoptera: Carabidae) and Pardosa saturatior (Araneae: Lycosidae). The cryophilic tardigrade Cryobiotus klebelsbergi is the apex consumer in cryoconite holes. This short food web highlights the fragility of nodes represented by invertebrates, contrasting with structured microbial communities in all glacier habitats. Although further research is necessary to quantify the ecological interactions of glacier organisms, this review summarises and integrates existing knowledge about the ecological processes on alpine glaciers and supports the importance of glacier‐adapted organisms in providing ecosystem services.
The self‐memory system: Exploring developmental links between self and memory across early to late childhood
Authors: Ross Josephine , Hutchison Jacqui , Cunningham Sheila J. 
Published: September 2024

AbstractThis study tests whether developments in self‐knowledge and autobiographical memory across early to late childhood are related. Self‐descriptions and autobiographical memory reports were collected from 379 three‐ to eleven‐year‐old predominantly white Scottish children, Mage = 90.3 months, SD = 31.1, 54% female. Episodic memory was measured in an enactment task involving recall and source monitoring of performed and witnessed actions. The volume and complexity of self‐knowledge and autobiographical memory reports increased with age, as did source monitoring ability and recall bias for own actions. Regression analyses and structural equation modeling confirmed a close association between these developments. These results inform our theoretical understanding of the development of the self‐memory system in childhood, which may contribute to the gradual offset of childhood amnesia.
Exploring the Relationships Between Clinical Examination Findings, Subjective Reported Symptoms and Objective Nasal Patency Measures in Nasal Obstruction: A Baseline NAIROS Sub‐Study Analysis
Authors: Maniam Pavithran , Bray Alison , Drinnan Michael , Fouweather Tony , Teare M. Dawn , Carrie Sean , O'Hara James 
Published: September 2024

ABSTRACTBackgroundThe role of objective nasal airflow measures using peak nasal inspiratory flow (PNIF) and rhinospirometry in supporting clinical examination findings when offering patients septoplasty remain undefined.ObjectiveTo explore the baseline relationships between clinical examination findings, subjective reported symptoms and objective nasal patency measures in nasal obstruction.MethodsThis is a sub‐study of the NAIROS trial. Participants with nasal obstruction secondary to septal deviation were included in this NAIROS sub‐study. The side of septal deviation, enlargement of inferior turbinate (IT), the need for IT reduction if septoplasty was being performed, the area of septum deflecting into the airway and observer rated airway block (ORAB–arbitrarily divided by <50% and >50% blockage) were assessed by clinicians. The subjective score of nasal obstruction was assessed using the Double Ordinal Assessed Subjective Scale (DOASS). Objective nasal patency measures (e.g., nasal partitioning ratio, [NPR] and PNIF) were measured using PNIF and rhinospirometry.ResultsThe mean NPR for left‐sided, both‐sided and right‐sided septal deviation was −0.35, −0.02 and 0.51, respectively (p < 0.001). There was very weak correlation between the requirement for IT reduction and PNIF change (0.13, p < 0.01). There was no difference in mean PNIF (94 L/min vs. 93 L/min) and mean DOASS (0.33 vs. 0.38) for participants with ORAB rated <50% and >50%. The mean NPR for participants with ORAB >50% was higher than for those with ORAB <50% (0.51 vs. 0.41, p = 0.002). There was strong correlation between the DOASS and NPR (+0.737, p < 0.001). The mean DOASS score for right‐sided, both‐sided and left‐sided septal deviation was 0.32, 0.05 and −0.29, respectively (p < 0.001).ConclusionThis study identified strong relationships between the clinician rated side of septal deflection, the patient reported DOASS and the objective NPR measurements. NPR and the clinician rated degree of airway blockage were concordant.
Association of sodium‐glucose cotransporter 2 inhibitors with risk of incident dementia and all‐cause mortality in older patients with type 2 diabetes: A retrospective cohort study using the TriNetX US collaborative networks
Authors: Pai Yen‐Wei , Chen I‐Chieh , Lin Jun‐Fu , Chen Xiao‐Hui , Chen Hsin‐Hua , Chang Ming‐Hong , Huang Jin‐An , Lin Ching‐Heng 
Published: September 2024

AbstractBackgroundLimited evidence exists to support any specific medication over others to prevent dementia in older patients with type 2 diabetes (T2D). We investigated whether treatment with sodium‐glucose cotransporter 2 (SGLT‐2) inhibitors is associated with a lower risk of incident dementia and all‐cause mortality, relative to dipeptidyl peptidase‐4 (DPP‐4) inhibitors and glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA).MethodsIn this retrospective, active‐comparator cohort study, we used data from the TriNetX electronic health records network. Our primary cohort comprised patients with T2D aged ≥50 years, registered between January 2012 and December 2022. Patients with a history of dementia were excluded. We used Kaplan–Meier survival analysis to estimate the incidence of dementia and all‐cause mortality in our cohort after they had used glucose‐lowering drugs for at least 12 months. Propensity score matching was performed to balance the SGLT‐2 inhibitor, DPP‐4 inhibitor and GLP‐1 RA cohorts. Subgroup analyses for sex and age were also conducted.ResultsOur first cohort comprised 193 948 patients treated with metformin and SGLT‐2 inhibitors and an equal number of patients treated with metformin and DPP‐4 inhibitors. In this cohort, the risk of dementia and all‐cause mortality was lower in patients treated with SGLT‐2 inhibitors than in those treated with DPP‐4 inhibitors (hazard ratio [HR]: 0.62, 95% confidence interval [CI]: 0.59–0.65, for dementia; HR: 0.54, 95% CI: 0.52–0.56, for all‐cause mortality).Our second cohort comprised 165 566 patients treated with metformin and SGLT‐2 inhibitors and an equal number of patients treated with metformin and GLP‐1 RAs. In this cohort, the risk of dementia and all‐cause mortality was lower in those treated with SGLT‐2 inhibitors than in those treated with GLP‐1 RAs (HR: 0.92, 95% CI: 0.87–0.98, for dementia; HR: 0.88, 95% CI: 0.85–0.91, for all‐cause mortality).ConclusionsThe use of SGLT‐2 inhibitor was associated with a lower risk of incident dementia and all‐cause mortality in older adults with T2D compared to DPP‐4 inhibitor and GLP‐1 RA.