bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short- and long-term debt determinants in Swedish SMEs
Authors: Öhman Peter , Yazdanfar Darush 
Published: February 2017

Purpose
This paper aims to empirically investigate the capital structure determinants of small and medium-sized enterprises (SMEs) with a particular focus on short- and long-term debt.

Design/methodology/approach
Several methods were used to analyse a sample of 15,897 Swedish SMEs for which complete financial information was available for a four-year period following the 2008 financial crisis, i.e. the 2009-2012 period.

Findings
The results indicate that eight explanatory variables – i.e. size, age, growth, profitability, liquidity, asset tangibility, non-debt tax shields and industry affiliation – are associated to various extents with SME debt policy.

Research limitations/implications
The current study is limited to examining a sample of Swedish SMEs in five industry sectors covering the 2009-2012 period. Further research could examine the generalizability of the present results by considering other countries, industry sectors and periods.

Practical implications
As debt policy influences firm performance, value and survival, SME owners and managers, regulators and financial institutions may benefit from studies considering a relatively large number of capital structure determinants, several of which are linked to short- and long-term debt in various ways.

Originality/value
This study is one of the few to examine the determinants of short- and long-term debt in SMEs, which play a fundamental role in the economy, using a large-scale cross-sectional database covering a period following the 2008 financial crisis.
Repeat Coronary Artery Dissection in Pregnancy: A Case Report and Review of the Literature
Authors: Bitting Casey P. , Zumwalt Ross E. 
Published: February 2017

AbstractNon‐atherosclerotic spontaneous coronary artery dissection (NA‐SCAD) is a rare cause of morbidity and mortality with a propensity for young, healthy, and often peripartum women. NA‐SCAD etiology is poorly understood, with possible hormonal and hereditary mechanisms. Current treatment strategies range from conservative management (often showing resolution on angiographic follow‐up) to invasive angiographic procedures. Rarely, NA‐SCAD has recurred in another coronary artery, ranging hours to years later. We report NA‐SCAD of the right coronary artery (RCA) in a 30‐year old, 3‐month postpartum female with an additional autopsy finding of remote myocardial infarction (MI) in the left anterior descending (LAD) coronary artery territory. The remote MI is consistent with prior NA‐SCAD of the LAD and, given the medical history, may have occurred in the peripartum period of the decedent first pregnancy 3 years earlier. As such, to the best of our knowledge, this may represent the first reported case of NA‐SCAD recurrence in a subsequent pregnancy.
Bilateral lung metastasectomy in carcinoma of the ampulla of Vater
Authors: Pih Gyu Young , Kim Dong Kwan , Park Kwang‐Min , Chang Heung‐Moon 
Published: February 2017

AbstractThe efficacy of lung metastasectomy is well established in several cancers, including colorectal cancer. However, little is known about the result of lung metastasectomy in carcinoma of the ampulla of Vater. Only two case reports have reported the efficacy of metastasectomy in ampullary cancer patients with pulmonary metastasis. We report the result of bilateral lung metastasectomy in a patient with ampullary cancer. A 63‐year‐old woman underwent pylorus‐preserving pancreaticoduodenectomy for carcinoma of the ampulla of Vater. About three years after the surgery, two non‐calcified lung nodules in the right lower and left upper lobes had developed. Wedge resections of both lung nodules were performed and the pathological examination showed that the lung nodules were pulmonary metastases from the ampullary cancer. Ten years after the lung surgery, the patient is well and there is no evidence of recurrence. Surgical resection could be considered in patients with pulmonary metastasis from ampulla of Vater cancer, even when the metastases are bilateral.
Vedolizumab exposure in pregnancy: outcomes from clinical studies in inflammatory bowel disease
Authors: Mahadevan U. , Vermeire S. , Lasch K. , Abhyankar B. , Bhayat F. , Blake A. , Dubinsky M. 
Published: February 2017

SummaryBackgroundVedolizumab is a gut‐selective immunoglobulin G1 monoclonal antibody to α4β7 integrin for the treatment of Crohn's disease (CD) and ulcerative colitis (UC). Prospective clinical studies of vedolizumab in pregnancy have not been conducted; therefore, existing safety data of vedolizumab in pregnancy were examined.AimTo assess pregnancy outcomes in females and partners of males who received vedolizumab.MethodsAll pregnancy data collected during the clinical programme (from 14 May 2007 to 27 June 2013) and in the post‐marketing setting (to 19 November 2015) were analysed.ResultsAcross six studies, there were 27 pregnancies in female participants and 19 pregnancies in partners of male participants. Among 24 vedolizumab‐treated females (23 with CD/UC, one healthy volunteer), there were 11 live births, five elective terminations, four spontaneous abortions and four undocumented outcomes. A congenital corpus callosum agenesis anomaly was reported in one live birth from a healthy volunteer with extensive obstetric history exposed to single‐dose vedolizumab 79 days before estimated conception. Of 19 pregnancies in partners of male participants, there were 11 live births, two spontaneous abortions, three elective terminations and three undocumented outcomes. Post‐marketing reports recorded 81 pregnancies, resulting in four live births, 11 spontaneous abortions and 66 pregnancies that were on‐going or reported undocumented outcomes.ConclusionsInitial analysis, limited by sample size and follow‐up, identified no new safety concerns for pregnancy outcomes in females directly or indirectly exposed to vedolizumab. However, vedolizumab should be used during pregnancy only if the benefits to the mother outweigh the risks to the mother/unborn child.
Impact of accelerometer and pedometer use on physical activity and glycaemic control in people with Type 2 diabetes: a systematic review and meta‐analysis
Authors: Baskerville R. , Ricci‐Cabello I. , Roberts N. , Farmer A. 
Published: February 2017

AbstractBackgroundSelf‐directed pedometer use increases physical activity levels in the general population; however, evidence of benefit for Type 2 diabetes is unclear and has not been systematically reviewed for accelerometers.AimTo examine the impact of using physical activity monitoring devices (pedometers and accelerometers) on free‐living physical activity and HbA1c levels in people with Type 2 diabetes.MethodsWe conducted a systematic literature review. Bibliographic databases included Medline, Embase, Web of Science, CINAHL, SportDiscus and the Cochrane Central Register of Controlled Trials. We included controlled trials evaluating interventions based on the use of pedometers or accelerometers to promote physical activity in people with Type 2 diabetes. Primary outcomes were physical activity (min/week or steps) and HbA1c [mmol/mol (%)]. Secondary outcomes were weight, blood pressure and lipid profile.ResultsTwelve trials (1458 participants) were identified, of which nine studied pedometers and three accelerometers. Random‐effects meta‐analysis showed an overall increase in physical activity (standardized mean difference 0.57, 95% CI 0.24, 0.91) in the intervention groups. Accelerometers and pedometers produced a similar effect size. No significant differences were observed in HbA1c, BMI, blood pressure or lipid profile.ConclusionsPeople with Type 2 diabetes, provided with an accelerometer or pedometer, substantially increased their free‐living physical activity. There is no evidence that monitor use alone improves HbA1c or other clinical outcomes. Further trials are needed to compare the relative effects of activity monitors within differing complex interventions.
Decreased biventricular longitudinal strain shortly after congenital heart defect surgery
Authors: de Boer Jonne M. , Kuipers Irene M. , Klitsie Liselotte M. , Blom Nico A. , ten Harkel Arend D. J. 
Published: February 2017

ObjectiveImpaired ventricular performance in patients who underwent surgery for congenital heart defect (CHD) may ultimately result in clinical heart failure. It is therefore important to regularly evaluate the left ventricular (LV) and right ventricular (RV) performance. We evaluated tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE) before and after surgical correction of a CHD.Study designPatients with CHD undergoing biventricular corrective surgery were included in this retrospective study. In addition, a group of healthy controls was included. The performance of LV, RV and interventricular septum (IVS) was assessed using mitral inflow velocities, TDI peak systolic (S′), peak early (E′) and peak late (A′) diastolic velocity. LV and RV global longitudinal strain (GLS) were assessed using STE. Measurements were performed preoperatively and at discharge.ResultsA total of 204 patients and 78 controls were included. All TDI measurements were significantly decreased after surgery. Nonetheless, LV S′ and A′ were still within normal limits. LV and RV GLS were significantly reduced after surgery and significantly lower compared to controls. A longer aortic cross‐clamp time and cardiopulmonary bypass (CPB) time were associated with significantly lower TDI and strain parameters in the RV and IVS, but not in the LV.ConclusionTDI and STE results generally imply a significantly lower ventricular performance in patients with CHD postoperatively. Furthermore, a negative correlation was observed between aortic cross‐clamping and CPB time and several RV performance parameters. As this association was not observed in the LV, this could implicate less vulnerability of the LV to cardiopulmonary bypass.
Words versus Deeds: Evidence from Post‐Call Manager Trades
Authors: Brockman Paul , Cicon James E. , Li Xu , Price S. McKay 
Published: February 2017

AbstractWe examine the impact of conference call tones on the direction and magnitude of subsequent manager trades. Our univariate results show that corporate insiders buy company shares following negative‐tone conference calls and sell shares following positive‐tone conference calls. This inverse call tone–trading pattern holds for both managers’ introductory sessions and subsequent question‐and‐answer (Q&A) sessions. Our multivariate results confirm the univariate call tone–trading patterns and show that contrarian manager trades are mostly driven by managerial selling activity. In contrast to the consistent and strong evidence of managers trading in the opposite direction of their call tones, we find no evidence of managers trading in the same direction of their call tones. We also examine the impact of analyst Q&A challenges on post‐call manager trades. Our findings suggest that managers learn from analyst feedback and adjust their post‐call trades accordingly.
Periodontal disease, tooth loss and dementia: Is there a link? A systematic review
Authors: Tonsekar Pallavi P. , Jiang Shuying S. , Yue Gang 
Published: February 2017

BackgroundIt has been suggested that dementia is caused by neuronal damage due to chronic inflammation from peripheral sources such as the oral cavity in periodontal disease.ObjectiveThe aim of our review was to assess the risk of dementia or cognitive impairment associated with chronic periodontitis and multiple tooth loss.Materials and methodsAn extensive search of electronic databases of articles on the relation between periodontitis, tooth loss and dementia published on or before April 2016 was conducted. Experimental and human studies that provided a description consistent with multiple tooth loss, chronic periodontal disease and cognitive impairment obtained by validated methods were selected. The data extracted from the articles included study design, country of origin, sample size, methods used to assess periodontitis and cognition, average age at the baseline and number of years of follow‐up. The Newcastle‐Ottawa scale was used to assess the quality of human studies.ResultsThe literature search yielded 756 articles which were independently screened, and 16 articles were included in the review. Four human studies reported an association of subsequent dementia with multiple tooth loss. One human study reported that chronic periodontal disease was associated with dementia. Eight experimental studies demonstrated an association between cognitive impairment and tooth loss.ConclusionThe literature on chronic periodontitis and multiple tooth loss as risk factors to dementia remains inconclusive. More randomised clinical trials on the association between periodontitis and dementia with uniform criteria for evaluation and diagnosis of periodontitis are warranted.
The assessment of organizational culture in cross‐cultural settings: Investigating the psychometric quality and cultural equivalence of three quantitative instruments
Authors: Puppatz Martin , Burmeister Anne , Deller Juergen 
Published: February 2017

AbstractThis study tested the psychometric quality and cultural equivalence of the German versions of three instruments for measuring organizational culture: the Denison Organizational Culture Survey (DOCS), the Organizational Culture Profile (OCP), and the Global leadership & organizational behavior effectiveness survey (GLOBE). Using an organizational sample from the banking industry, we analyzed the metric equivalence (by means of assessing the psychometric quality), the conceptual equivalence (by means of assessing the construct validity) as well as the linguistic and functional equivalence of the three instruments. The results indicate that the psychometric properties and the equivalence of the DOCS and the OCP can be summarized as satisfactory. In contrast, reliability indices of the GLOBE scales were far below recommended thresholds and results regarding its construct validity were unsatisfying. Conceptual equivalence could therefore not be assumed. Avenues for future research and implications for practitioners are discussed. In addition, the authors created and tested a German translation of the OCP scales and an adapted version of the German DOCS scales.
Applying organizational justice theory to admission into higher education: Admission from a student perspective
Authors: Niessen A. Susan M. , Meijer Rob R. , Tendeiro Jorge N. 
Published: February 2017

AbstractApplicant perceptions of methods used in admission procedures to higher education were investigated using organizational justice theory. Applicants to a psychology study program completed a questionnaire about several admission methods. General favorability, ratings on justice dimensions, relationships between general favorability and these dimensions, and differences in perceptions based on gender and on the aim of the admission procedure (selection or matching) were studied. In addition, the relationship between favorability and test performance, and the relationship between favorability and behavioral outcomes were investigated. Applicants rated interviews and trial‐studying tests most favorably. Contrary to expectations based on the existing literature, high school grades were perceived least favorably and there was no relationship between applicant perceptions and enrollment decisions. In line with previous research in the employment literature, general favorability was most strongly related to face validity, study‐relatedness, applicant differentiation, the chance to show skills, perceived scientific evidence, and perceived wide‐spread use. We found no differences in applicant perceptions based on gender and small differences based on the aim of admission procedures. These results extend the applicant perceptions literature to educational admission and the results are useful for administrators when choosing methods to admit students.
A deskilling and challenging journey: the lived experience of Indonesian nurse returnees
Authors: Kurniati A. , Chen C.‐M. , Efendi F. , Ogawa R. 
Published: February 2017

AimTo illuminate the lived experiences of Indonesian nurses who previously worked as caregivers in Japanese residential care facilities, by exploring the journey of becoming returnees.BackgroundThe creation of bilateral agreements between Indonesia and Japan has facilitated the movement of Indonesian nurses to work as caregivers in Japan since 2008. While this decision raised concerns with regard to the degradation of nursing skills, little is known about this issue from the perspective of nurse returnees and how the experience affects their life.MethodA hermeneutic phenomenological method was employed for this study. A purposive sample of 15 Indonesian nurse returnees participated in this study. Semi‐structured interviews were conducted in four of Indonesia's provinces between August and October 2015. Data were analysed thematically, supported by QSR NVIVO 10 software.FindingsFour key themes emerged from the data analysis: (i) returning home; (ii) going back to zero; (iii) walking through a difficult journey; and (iv) overcoming barriers. These findings described the lived experiences of nurse returnees when they got back to the country of origin.ConclusionIndonesian nurse returnees experienced deskilling and struggled to re‐enter the nursing profession or to find other non‐nursing jobs. The significant impact of this migration on individual nurses with regard to maximizing the benefits of return migration deserves further investigation.Implication for nursing and health policyThe Indonesian government, jointly with other stakeholders, should develop a brain gain strategy to align returnees’ expertise with the needs of the national labour market. The public‐private partnership should be strengthened to utilize returnees in healthcare services.
The influence of reference effect on pricing strategies in revenue management settings
Authors: Yang Hui , Zhang Ding , Zhang Chen 
Published: February 2017

AbstractThis paper studies the reference effect on dynamic pricing in revenue management for cases with limited capacity and stochastic demand. We first present a single‐period fixed pricing (FP) model in finite horizon with fixed capacity and stochastic demand, and show that there is a unique optimal solution. The model is then extended to a discrete‐time dynamic pricing (DP) model as a benchmark case. We subsequently propose a DP model with reference effect (DPR), investigate the properties of the revenue function, and present a computational scheme to compute the dynamic optimal price. Numerical experiments are conducted to exhibit how the reference effect may influence the initial price, pricing trend, price dispersion, and expected revenue, with the FP, DP, and DPR policies in the same environment of a fixed capacity facing stochastic demand. We also present, through numerical examples, a comparison between deterministic demand and stochastic demand scenarios under reference effect, and with a fixed initial price versus a variable initial price.
The European Parliament as a Forum of National Interest? A Transnationalist Critique of Jürgen Habermas' Reconstruction of Degressive Proportionality
Authors: von Achenbach Jelena 
Published: February 2017

AbstractArguing from a transnationalist perspective, this contribution contests Jürgen Habermas' reconstruction of degressive proportionality according to which the principle is justified as a mechanism empowering national interest. The critique is developed on legal, empirical and normative grounds. In the first step, the article demonstrates that the European Parliament (EP) is legally designed to serve as a medium of transnational political alignments. Based on empirical studies, it then shows that the members of the EP exercise their representative role as advocates of political platforms of a cross‐border nature. Normatively, the contribution argues that it is possible to reconstruct degressive proportionality from a transnationalist, European perspective: The purpose of this complex legal construction is to establish the conditions of an open, fair and pluralistic transnational discourse in the EP. Degressive proportionality allows for heterogeneity and diversity within the Union citizenry, which remains – for the time being – divided in national constituencies, to be articulated politically.
Promising therapeutic efficacy of a novel reduced expression in immortalized cells/dickkopf‐3 expressing adenoviral vector for hepatocellular carcinoma
Authors: Sawahara Hiroaki , Shiraha Hidenori , Uchida Daisuke , Kato Hironari , Kato Ryo , Oyama Atsushi , Nagahara Teruya , Iwamuro Masaya , Horiguchi Shigeru , Tsutsumi Koichiro , Mandai Mari , Mimura Tetsushige , Wada Nozomu , Takeuchi Yasuto , Kuwaki Kenji , Onishi Hideki , Nakamura Shinichiro , Watanabe Masami , Sakaguchi Masakiyo , Takaki Akinobu , Nouso Kazuhiro , Yagi Takahito , Nasu Yasutomo , Kumon Hiromi , Okada Hiroyuki 
Published: February 2017

AbstractBackground and AimReduced expression in immortalized cells (REIC)/dickkopf‐3 (Dkk‐3) is a tumor suppressor gene that is downregulated in various cancers. In our previous study of prostate cancer, the REIC/Dkk‐3‐expressing adenoviral vector (Ad‐REIC) was found to induce cancer‐selective apoptosis. This study recently developed a novel super gene expression (SGE) system and used this system to re‐construct an Ad‐REIC vector, termed the Ad‐SGE‐REIC, to achieve more effective therapeutic outcomes. In this study, the therapeutic effects of Ad‐SGE‐REIC on hepatocellular carcinoma (HCC) was assessed.MethodsHuman HCC cell lines (HLE, Huh7, HepG2, HLF, SK‐Hep1, and PLC), human HCC tissues, and mouse HCC cell line (Hepa1‐6) were used in this study. REIC/Dkk‐3 expression was assessed by immunoblotting and immunohistochemistry. The relative cell viability and the apoptotic effect were examined in vitro, and the anti‐tumor effects of Ad‐SGE‐REIC treatment were analyzed in the mouse xenograft model. This study additionally assessed anti‐tumor immunological effects on the immunocompetent mice.ResultsREIC/Dkk‐3 expression was decreased in HCC cell lines and HCC tissues. Ad‐SGE‐REIC reduced cell viability and induced apoptosis in HCC cell lines (HLE and Huh7), inhibited tumor growth in the mouse xenograft model, and demonstrated in vivo anti‐cancer immunostimulatory effects on the HCC cell line (Hepa1‐6).ConclusionsAd‐SGE‐REIC treatment not only enhanced cell killing effects in vitro but also elicited significant therapeutic effects, with tumor growth suppression, in vivo. REIC/Dkk‐3 gene therapy using Ad‐SGE‐REIC potentially represents an innovative new therapeutic tool for HCC.
Diatom life cycles and ecology in the Cretaceous
Authors: Jewson David H. , Harwood David M. 
Published: February 2017

The earliest known diatom fossils with well‐preserved siliceous frustules are from Lower Cretaceous neritic marine deposits in Antarctica. In this study, we analyzed the cell wall structure to establish whether their cell and life cycles were similar to modern forms. At least two filamentous species (Basilicostephanus ornatus and Archepyrgus melosiroides) had girdle band structures that functioned during cell division in a similar way to present day Aulacoseira species. Also, size analyses of cell diameter indicated that the cyclic process of size decline and size restoration used to time modern diatom life cycles was present in five species from the Lower Cretaceous (B. ornatus, A. melosiroides, Gladius antiquus, Ancylopyrgus reticulatus, Kreagra forfex) as well as two species from Upper Cretaceous deposits (Trinacria anissimowii and Eunotogramma fueloepi) from the Southwest Pacific. The results indicate that the “Diatom Sex Clock” was present from an early evolutionary stage. Other ecological adaptations included changes in mantle height and coiling. Overall, the results suggest that at least some of the species in these early assemblages are on a direct ancestral line to modern forms.