bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of ultrasound, thermography and subepidermal moisture in predicting pressure ulcers: a systematic review
Authors: Oliveira A.L. , Moore Z. , O´Connor T. , Patton D. 
Published: May 2017

Objective: Our aims were to: establish the clinical significance of ultrasound, thermography, photography and subepidermal moisture (SEM) measurement; determine the accuracy of ultrasound, thermography, photography and SEM measurement in detecting skin/tissue damage; determine the relative accuracy of one of these assessment methods over another; make recommendations for practice pertaining to assessment of early skin/tissue damage. Method: The following databases, Cochrane Wounds Group Specialised Register, The Cochrane Central Register of Controlled Trials, Ovid MEDLINE, Ovid EMBASE, Elsevier version, EBSCO CINAHL, ClinicalTrials.gov , WHO International Clinical Trials Registry (ICTR) and The EU Clinical Trials Register were searched for terms including; thermography, ultrasound, subepidermal moisture, photograph and pressure ulcer. Results: We identified four SEM, one thermography and five ultrasound studies for inclusion in this review. Data analysis indicated that photography was not a method which allowed for the early prediction of PU presence. SEM values increased with increasing tissue damage, with the sacrum and the heels being the most common anatomical locations for the development of erythema and stage I PUs. Thermography identified temperature changes in tissues and skin that may give an indication of early PU development; however the data were not sufficiently robust. Ultrasound detected pockets of fluid/oedema at different levels of the skin that were comparable with tissue damage. Thus, SEM and ultrasound were the best methods for allowing a more accurate assessment of early skin/tissue damage. Using the EBL Critical Appraisal Tool the overall validities of the studies varied between 33.3–55.6%, meaning that there is potential for bias within all the included studies. All of the studies were situated at level IV, V and VII of the evidence pyramid. Although the methodological quality of the studies warrants consideration, these studies showed the potential that SEM and ultrasound have in early PU detection. Conclusion: SEM and ultrasound are promising in the detection and prediction of early tissue damage and PU presence. However, these methods should be further studied to clarify their potential for use more widely in PU prevention strategies.
Clinical outcomes and cost-effectiveness of three different compression systems in newly-diagnosed venous leg ulcers in the UK
Authors: Guest J.F. , Fuller G.W. , Vowden P. 
Published: May 2017

Objective: To assess clinical outcomes and cost-effectiveness of using a two-layer cohesive compression bandage (TLCCB; Coban 2) compared with a two-layer compression system (TLCS; KTwo) and a four-layer compression system (FLCS; Profore) in treating newly-diagnosed venous leg ulcers (VLUs) in clinical practice in the UK, from the perspective of the NHS. Method: This was a retrospective cohort analysis of the case records of patients with newly-diagnosed VLUs randomly extracted from The Health Improvement Network (THIN) database (a nationally representative database of clinical practice among patients registered with general practitioners in the UK) who were treated with either TLCCB (n=200), TLCS (n=200) or FLCS (n=200). The clinical outcomes and cost-effectiveness of the alternative compression systems were estimated over six months after starting treatment. Results: Patients' mean age was 72 years and 58% were female. Time from wound onset to the start of compression was a mean of two months, and when starting compression the wound size was a mean of 45 cm2. The distribution of healing was significantly different between the three groups; 76% of wounds in the TLCCB group healed by six months compared with 70% and 64% in the TLCS and FLCS groups, respectively (p=0.006). Time to healing was significantly less in the TLCCB group compared with the two other groups (p=0.003). Patients in the TLCCB group experienced better health-related quality of life over six months (0.413 quality-adjusted life years (QALYs) per patient), compared with the TLCS and FLCS groups (0.404 and 0.396 QALYs per patient, respectively). The mean six-month NHS management cost was £3045, £3842 and £4480 per patient in the TLCCB, TLCS and FLCS groups, respectively. Conclusion: Real-world evidence demonstrates that treating newly-diagnosed VLUs with TLCCB, compared with the other two compression systems, affords a more cost-effective use of NHS-funded resources in clinical practice since it resulted in an increased healing rate, better health-related quality of life and a reduction in NHS management cost.
When borderlands are where we live: Disgrace (Jacobs, 2008), Invictus (Eastwood, 2009) and District 9 (Blomkamp, 2009)
Authors: Moya Ana 
Published: May 2017

Abstract
This article discusses the nature and role of borderlands in Disgrace (Jacobs, 2008), Invictus (Eastwood, 2008) and District 9 (Blomkamp, 2009). Though rape, a rugby team and a group of aliens are apparently very different points of departure for a story, the article proves how these films adapt a single tale of borderlands in postapartheid South Africa, elaborating on the plurality of angles from which such a story may be told. The article discusses the poetics of the border at work in these films and the ways in which they explore the border as a site of struggle. In this sense, the article proves the extent to which borderland theory offers the necessary critical frame for a fruitful discussion of these films with the border becoming a productive epistemic angle; a suitable method for the critical discussion of global passages of people, money or objects.
Elelwani (2012): A Third Cinema analysis of a Venda tale of a young woman’s journey of self-discovery
Authors: Tager Michele 
Published: May 2017

Abstract
Elelwani directed by Wa-Luruli in 2012 is a Tshivenda film based on a novel by Titus Ntsieni Maumela. The film highlights the subjugation and oppression of women in Tshivenda culture by telling the story of a young woman who returns to her family’s rural home in Venda after completing her education, only to be informed by her parents that she is obligated to marry the King in return for the education she received, as well as to save her family from financial ruin. This article presents an analysis of Elelwani in terms of aspects of Third Cinema theory, with a view to showing how the film tells an African story and delivers its message of female empowerment.
Measuring Digitalization – Key Metrics
Authors: Kotarba Marcin 
Published: May 2017

Abstract
The article covers an analysis of metrics used to measure digitalization activities. Five main levels are analyzed - moving from the metrics of the digital economy to society, industry, enterprise, and clients. The study is based on leading public and commercial metrics used for the evaluation of the digital progress. The similarities and differences between key performance indicators on each level are discussed, forming a set of conclusions on the scope and maturity of various measurement systems and potential improvement options.
“It’s a big world in here”: Contemporary Voyage Drama and the Politics of Mobility
Authors: Wilkie Fiona 
Published: May 2017

AbstractIn Renaissance and Restoration England, many popular plays functioned as “voyage dramas,” offering opportunities for vicarious tourism to their audiences (McInnis 2012). The theatre became one site in which to receive and negotiate information about elsewhere, at a time before mass access to travel was available. The tagline of London’s Young Vic theatre – “It’s a big world in here” – suggests that something of this spirit survives in twenty-first-century performance. It is a sentiment that we find also in the festival director Mark Ball’s assertion that “theatre is my map of the world.” But the version of the world created here is necessarily skewed by a politics of mobility (Cresswell 2010): the uneven frictions, routes, speeds, levels of comfort, and power relations affecting how theatre-makers and productions move around the world. And contemporary audiences are themselves likely to come to the theatre with multiple and unequal experiences of travel. This article asks what function contemporary voyage dramas serve in a context of the widespread mobility of people, finance, goods and ideas, and what might be the political challenges of representing travel in the theatre. It investigates the claim to authenticity, the negotiation of privilege and remoteness, and the role of the performer as mediator in theatrical travel narratives. In particular, it focuses on Simon McBurney’s solo performance
The size prediction of potential inclusions embedded in the sub-surface of fused silica by damage morphology
Authors: Gao Xiang , Qiu Rong , Wang Kunpeng , Zhang Jiangmei , Zhou Guorui , Yao Ke , Jiang Yong , Zhou Qiang 
Published: May 2017

Abstract
A model for predicting the size ranges of different potential inclusions initiating damage on the surface of fused silica has been presented. This accounts for the heating of nanometric inclusions whose absorptivity is described based on Mie Theory. The depth profile of impurities has been measured by ICP-OES. By the measured temporal pulse profile on the surface of fused silica, the temperature and thermal stress has been calculated. Furthermore, considering the limit conditions of temperature and thermal stress strength for different damage morphologies, the size range of potential inclusions for fused silica is discussed.
Physical-chemical properties studying of molecular structures via topological index calculating
Authors: Wu Jianzhang , Farahani Mohammad Reza , Yu Xiao , Gao Wei 
Published: May 2017

Abstract
It’s revealed from the earlier researches that many physical-chemical properties depend heavily on the structure of corresponding moleculars. This fact provides us an approach to measure the physical-chemical characteristics of substances and materials. In our article, we report the eccentricity related indices of certain important molecular structures from mathematical standpoint. The eccentricity version indices of nanostar dendrimers are determined and the reverse eccentric connectivity index for V-phenylenic nanotorus is discussed. The conclusions we obtained mainly use the trick of distance computation and mathematical derivation, and the results can be applied in physics engineering.
Solipsism – The Leitmotif in Wittgenstein’s Life and Philosophy
Authors: Gabriel Gottfried 
Published: May 2017

AbstractThis paper will highlight the close relationship between Wittgenstein’s life and train of thought, using his treatment of solipsism as an example. The intensity with which Wittgenstein explored this theme hints towards an existential and cultural background that is further developed in a comparison of his works with the entries in his diaries. The treatment of solipsism will be presented as an expression of an inner wrestling for the correct view of world and life. The transition from early to late philosophical thought is paired with a revised understanding of the concept of a felicitous life, which in turn is reflected in an altered understanding of language. The replacement of an analysis of the general form of propositions by the description of language games and the departure from logical forms towards forms of life - from a practical point of view - corresponds with a new approach to overcoming alienation.For a systematic assessment of Wittgenstein’s initial espousal of solipsism (in the Tractatus) and his later criticism (in the Philosophical Investigations), the various types of solipsism, which Wittgenstein used as benchmarks, will be taken into consideration, in particular, Weininger’s ethical solipsism, Schopenhauer’s contemplative aesthetic solipsism as well as Descartes’ methodological solipsism.
Wittgenstein’s Natural-Historical Investigations
Authors: Guetti Edward 
Published: May 2017

AbstractIn this essay I try to sketch the difficulties that face anyone writing about Wittgenstein’s later method. I then insist that an underappreciated remark of his be taken seriously: that his method be seen as natural-historical. There are several difficulties that result from taking this stance, and I believe I address each of them after developing a fuller picture of what a “natural-historical method” will mean (and here I am broadly following lines laid out by Michael Thompson). I conclude with literary examples (Sebald’s Austerlitz and his Rings of Saturn) in order to exemplify further the recuperative and fantasy-defeating potential of a natural-historical method akin to Wittgenstein’s.
„James’s book The Varieties of Religious Experience does me a lot of good.“
Authors: Nagl Ludwig 
Published: May 2017

AbstractWittgenstein zitiert in seinen Schriften nur wenige Autoren, den amerikanischen Pragmatisten William James bis in sein Spätwerk hinein jedoch mit auffallender Häufigkeit. Das hängt - so die Leitthese des Beitrags - vor allem mit der Rolle zusammen, die James‘ Erkundungen des Religiösen für Wittgensteins Nachdenken über Religion spielen. Der intrikaten Verbindung Wittgenstein-James wird in sieben Reflexionen nachgegangen: 1. Krisis der Lebenspraxis: „The Sick Soul“ (James, Tolstoi, Wittgenstein); 2. Das existentiell dimensionierte „Paradoxon“ als rektifizierte/dekonstruierte Dialektik? Wittgensteins (beredtes?) Schweigen im Tractatus; 3. Kann Reflexion stillgestellt werden? „Therapie“ als „Ende der Philosophie“? 4. Kritische Eindämmung des „Szientismus“: Wittgensteins und James‘ Einsprüche gegen die „survival theory of religion“; 5. Exkurs zum Jamesschen Thematisierungsversuch des „Mystischen“; 6. James und Wittgenstein über das „institutionalisierte“ Religiöse: „Religion - a matter between me and God only“? - „Subjektive“ Religiosität vs. „korporative“ Religion; 7. Coda. Die (innere) Ambivalenz religiöser Motivation: Sami Pihlströms (post‐) Wittgensteinsche Reflexionen.
Structural studies of (E)-2-(benzylidene)-1-tetralone derivatives: crystal structures and Hirshfeld surface analysis
Authors: Baddeley Thomas C. , Gomes Ligia R. , Low John N. , Turner Alan B. , Wardell James L. , Watson Graeme J. R. 
Published: May 2017

Abstract
Crystal structures are reported from data collected at 100 K of (E)-2-(X-benzylidene)-1-tetralone (2: X=3-O2N; 3: X=4-O2N; 5: X=4-HO; 6: X=4-Me2N; 7: 4-NC), (E)-2-(X-benzylidene)-6-MeO-1-tetralone, 8, and (E)-2-(X-benzylidene)-5-MeO-1-tetralone 9. Also reported herein are the Hirshfeld surface calculations for these compounds as well as those of (E)-2-(X-benzylidene)-1-tetralone (1: X=H; 4: X=4-MeO), whose structures were previously reported. The molecules are not planar as shown by the dihedral angles of 45.66(5)–69.78(5)° between the phenyl groups and by the puckered cyclohexenyl rings. A common feature of the molecular conformations is the C–H···O1(carbonyl) intramolecular hydrogen bond. The carbonyl oxygen atom plays significant roles in the interactions in all compounds baring compound 8. However, there is no consistent set of intermolecular interaction in this group of compounds. Intermolecular interactions present in each compound are some of the O–H···O, C–H···A (A=O, N or π), A–O···π (A=C or N) and π···π interactions. The only compound exhibiting a classical O–H···O hydrogen bond is compound 5. C–H···π interactions are found in all compounds, and while π···π interactions are present in compounds 2, 3, 7 and 9, no consistent type of stacking arrangement is shown. The Hirshfeld surface calculations, while generally concurring with the intermolecular interactions indicated by PLATON analyses, also reveal short interactions, which fall below the PLATON cut-off parameters.
Electron transfer-induced oxidation of 2,3-dihydroquinazolin-4(1H)-ones
Authors: Memarian Hamid Reza , Ghahremani Saeideh 
Published: May 2017

Abstract
A series of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones were oxidized to quinazolin-4(3H)-ones using tetrabutylammonium peroxydisulfate. The rate and the outcome of the reaction are dependent on the type and nature of 2-substitution. An electron transfer mechanism is proposed for this study, which is supported by the retention or elimination of 2-substitution during the oxidation process.
Effects of the Inertia Barbell Training on Lumbar Muscle T2 Relaxation Time
Authors: Sun Ming-Yun , Lü Jian-Qiang , Ma Zu-Chang , Lü Jiao-Jiao , Huang Qing , Sun Yi-Ning , Liu Yu 
Published: May 2017

Abstract
Sun, M-Y, Lu, J-Q, Ma, Z-C, Lü, J-J, Huang, Q, Sun, Y-N, and Liü, Y. Effects of the inertia barbell training on lumbar muscle T2 relaxation time. J Strength Cond Res 34(12): 3454–3462, 2020—The purpose of this study was to investigate variations in T2 relaxation time in normal human lumbar muscles caused by inertia barbell training. Thirty undergraduate healthy men (mean age = 19 ± 1.2 years, body mass = 72 ± 10.0 kg, and height = 1.78 ± 0.1 m) were recruited to participate in this study. Subjects were randomly assigned into 2 groups: an inertia barbell training group (IBTG) (n = 15) and a normal barbell-training group (NBTG) (n = 15). All subjects participated in lumbar flexion and extension muscle strength training for 1 hour per time, 3 times per week for a total of 8 weeks. The lumbar area of each subject was scanned before and after the experiment using a 3.0T superconductive magnetic resonance imaging system. The T2 values measured after intervention were significantly different compared with the T2 values measured before the experiment in both the IBTG and NBTG groups (p < 0.001). After intervention, there was no significant difference in T2 values between the IBTG and NBTG groups (p = 0.17). The (∆T2)/T2 percentage was significantly different in the IBTG group (p < 0.01). This study demonstrated that 8 weeks of strength training led to significant improvements in the values for T2 relaxation time of the lumbar muscles. Furthermore, the (∆T2)/T2 percentage for IBTG was higher than that for NBTG, which suggested that lumbar muscle activity increased more with inertial barbell training.
Ladder Treadmill: A Method to Assess Locomotion in Cats with an Intact or Lesioned Spinal Cord
Authors: Escalona Manuel , Delivet-Mongrain Hugo , Kundu Aritra , Gossard Jean-Pierre , Rossignol Serge 
Published: May 2017

After lesions of the CNS, locomotor abilities of animals (mainly cats) are often assessed on a simple flat treadmill (FTM), which imposes little demands on supraspinal structures as is the case when walking on targets. Therefore, the aims of the present work were as follows: (1) to develop a treadmill allowing the assessment of locomotion of intact cats required to place the paws on the rungs of a moving ladder treadmill (LTM); (2) to assess the capability of cats after a unilateral spinal hemisection at T10 to cope with such a demanding locomotor task; and (3) to regularly train cats for 6 weeks on the LTM to determine whether such regular training improves locomotor recovery on the FTM. A significant improvement would indicate that LTM training maximizes the contribution of spinal locomotor circuits as well as remnant supraspinal inputs. Together, we used 9 cats (7 females, 2 males). Six were used to compare the EMG and kinematic locomotor characteristics during walking on the FTM and LTM. We found that the swing phase during LTM walking was slightly enhanced as well as some specific activity of knee flexor muscles. Fore-hindlimb coupling favored a more stable diagonal coupling. These 6 cats were then hemispinalized and trained for 6 weeks on the LTM, whereas the 3 other cats were hemispinalized and trained solely on the FTM to compare the two training regimens. Intensive LTM training after hemisection was found to change features of locomotion, such as the foot trajectory as well as diminished paw drag often observed after hemisection.SIGNIFICANCE STATEMENTThis paper introduces a method (ladder treadmill [LTM]) to study the locomotor ability of cats with an intact spinal cord or after a unilateral hemisection to walk with a precise foot placement on the rungs fixed to an ordinary flat treadmill (FTM). Because cats are compared in various conditions (intact or hemisected at different time points) in the same enclosure on the FTM and the LTM, the changes in averaged locomotor characteristics must reflect the specificity of the task and the neurological states. Furthermore, the ladder treadmill permits to train cats repetitively for weeks and observe whether training regimens (FTM or LTM) can induce durable changes in the parameters of locomotion.
Activity Clamp Provides Insights into Paradoxical Effects of the Anti-Seizure Drug Carbamazepine
Authors: Morris Gareth , Leite Marco , Kullmann Dimitri M. , Pavlov Ivan , Schorge Stephanie , Lignani Gabriele 
Published: May 2017

A major challenge in experimental epilepsy research is to reconcile the effects of anti-epileptic drugs (AEDs) on individual neurons with their network-level actions. Highlighting this difficulty, it is unclear why carbamazepine (CBZ), a frontline AED with a known molecular mechanism, has been reported to increase epileptiform activity in several clinical and experimental studies. We confirmed in anin vitromouse model (in both sexes) that the frequency of interictal bursts increased after CBZ perfusion. To address the underlying mechanisms, we developed a method, activity clamp, to distinguish the response of individual neurons from network-level actions of CBZ. We first recorded barrages of synaptic conductances from neurons during epileptiform activity and then replayed them in pharmacologically isolated neurons under control conditions and in the presence of CBZ. CBZ consistently decreased the reliability of the second action potential in each burst of activity. Conventional current-clamp recordings using excitatory ramp or square-step current injections failed to reveal this effect. Network modeling showed that a CBZ-induced decrease of neuron recruitment during epileptic bursts can lead to an increase in burst frequency at the network level by reducing the refractoriness of excitatory transmission. By combining activity clamp with computer simulations, the present study provides a potential explanation for the paradoxical effects of CBZ on epileptiform activity.SIGNIFICANCE STATEMENTThe effects of anti-epileptic drugs on individual neurons are difficult to separate from their network-level actions. Although carbamazepine (CBZ) has a known anti-epileptic mechanism, paradoxically, it has also been reported to increase epileptiform activity in clinical and experimental studies. To investigate this paradox during realistic neuronal epileptiform activity, we developed a method, activity clamp, to distinguish the effects of CBZ on individual neurons from network-level actions. We demonstrate that CBZ consistently decreases the reliability of the second action potential in each burst of epileptiform activity. Network modeling shows that this effect on individual neuronal responses could explain the paradoxical effect of CBZ at the network level.