bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seeing Speech Production Through the Window of Complex Interactions: Introduction to the Supplement of Select Papers From the 10th International Seminar on Speech Production (ISSP) in Cologne
Authors: Fuchs Susanne , Lancia Leonardo 
Published: December 2016

Purpose
As the famous linguist and anthropologist C. Hockett noted about 30 years ago, “What one sees of language, as of anything, depends on the angle of view, and different explorers approach from different directions. Unfortunately, sometimes they become so enamored of their particular approach that they incline to scoff at any other, so that instead of everybody being the richer for the variety, everybody loses. … It is obviously impossible to see all of anything from a single vantage point. So it is never inappropriate to seek new perspectives” (Hockett, 1987, p. 1). This supplement takes such a broad perspective and contains a selection of peer-reviewed papers seeing speech production through the window of complex interactions between physical, linguistic, social, and communicative factors. Papers were presented at the 10th International Seminar on Speech Production in Cologne. We hope to encourage the reader to continue working in this exciting direction.
Second‐order sliding mode control for power optimisation of DFIG‐based variable speed wind turbine
Authors: Liu Xiangjie , Han Yaozhen , Wang Chengcheng 
Published: December 2016

Power optimisation is quite important for the doubly‐fed induction generator (DFIG)‐based variable speed wind turbine (VSWT) in the modern renewable power generation system. However, the VSWTs are generally non‐linear and uncertain systems. This study proposes a super‐twisting second‐order sliding mode (SOSM) control scheme to maximise the wind energy capture of a DFIG‐based VSWT system, and regulate the stator reactive power to follow the grid requirements. By regulating the generator rotor voltage, the designed SOSM controller makes the wind turbine rotor speed track the optimal speed to maximise the power generation, and controls the rotor current to follow the external reference to regulate the stator reactive power. A quadratic form Lyapunov function is adopted to determine the range of controller parameters and guarantee the finite time stability. Simulation results on a 1.5 MW DFIG‐based VSWT demonstrate the effectiveness of the proposed control strategy.
Prenatal Ultrasonographic Diagnosis of Cataract: In Utero Manifestations of Cryptic Disease
Authors: Ashwal Eran , Achiron Asaf , Gilboa Yinon , Berkenstadt Michal , Rosner Mordecai , Achiron Reuven 
Published: December 2016

Abstract
Purpose To report and review our experience with antenatal evaluation for fetuses diagnosed with congenital cataract.
Materials and Methods We retrospectively identified pregnancies diagnosed with fetal cataract during antenatal ultrasound. Evaluation of fetal eyes included intraocular anatomy and biometry. Data on fetal malformations, serology and fetal karyotype were collected.
Results 8 cases, identified over the course of 10 years, were reviewed. Week 15 was the mean time for diagnosis (range 11 – 34). Extraocular anomalies were demonstrated in 6 cases (central nervous system, cardiac and renal systems). Additional intraocular abnormalities were detected in two cases: one fetus had persistent hyperplastic primary vitreous and another had bilateral retinal detachment. All cases but one involved cataracts in both eyes. The unilateral case was associated with microphthalmic aphakia. All cases had negative serology for TORCHs. 7 out of the 8 fetuses were terminated. The only one who survived developed in utero cataracts secondary to maternal steroid therapy. He underwent bilateral cataract extraction during the first weeks of life and ophthalmologic evaluation at 2 years of age was unremarkable, without any visual impairment.
Conclusion In most cases, fetal cataract was associated with additional abnormalities, both intra- and extra-ocular. In instances when cataracts are isolated, we suggest conducting a detailed and thorough in utero ophthalmic examination in order to improve antenatal parental counselling.
Marktdurchdringung von neuen Arzneimitteln
Authors: de Millas Christoph , Höer Ariane , Zimmermann Anne , Häussler Bertram 
Published: December 2016

Zusammenfassung
Zielsetzung Mit dem Arzneimittelmarktneuordnungsgesetz (AMNOG) wurde 2011 die frühe Nutzenbewertung in Deutschland eingeführt. Die vorliegende Analyse untersucht, ob in den ersten zwei Jahren nach Markteinführung ein Unterschied in der Marktdurchdringung für Neueinführungen vor und nach AMNOG besteht und ob die Höhe des Zusatznutzens die Marktdurchdringung beeinflusst.
Methodik Die Analyse betrachtet 65 bzw. 40 Wirkstoffe, die vor bzw. nach Einführung der frühen Nutzenbewertung in den Markt kamen (Prä- bzw. Post-AMNOG-Wirkstoffe). Markteinführung der Wirkstoffe war zwischen Januar 2005 und Dezember 2013. Die Marktdurchdringung wurde berechnet als Anteil des realen ambulanten Verbrauchs in der gesetzlichen Krankenversicherung gemessen in definierten Tagesdosen (DDD – „defined daily dose“) am zu erwartenden Verbrauch auf der Grundlage der Zielpopulation. Zur Operationalisierung des Zusatznutzens wurden die Beschlüsse des Gemeinsamen Bundesausschusses abhängig von Zusatznutzen und Ergebnissicherheit auf einer Ordinalskala bewertet.
Ergebnisse Über alle Wirkstoffe hinweg erreichten die Post- im Vergleich zu den Prä-AMNOG-Wirkstoffen im Durchschnitt eine numerisch höhere Marktdurchdringung. Der Unterschied war nicht statistisch signifikant. An zwei Anwendungsgebieten wird beispielhaft gezeigt, dass die Marktdurchdringung von den spezifischen Marktgegebenheiten abhing. Es konnte kein Zusammenhang zwischen dem Ergebnis der Nutzenbewertung und der Höhe der Marktdurchdringung nachgewiesen werden.
Schlussfolgerung Die Ergebnisse der Analyse geben weder einen Hinweis darauf, dass die frühe Nutzenbewertung die Anwendung neuer Arzneimittel fördert, noch dass sie diese behindert.
Die Gestaltung von Zielvereinbarungen in Chefarztverträgen unter Berücksichtigung von regulatorischen Vorgaben
Authors: Lohmann Christian 
Published: December 2016

Zusammenfassung
Zielsetzung Der Einsatz von Zielvereinbarungen als Grundlage der variablen Vergütung von Chefärzten wird durch die regulatorischen Bestimmungen des § 135c SGB V n. F. sowie berufsrechtliche Vorgaben erheblich eingeschränkt. Der vorliegende Beitrag analysiert die Auswirkungen auf die Zweckmäßigkeit sowie den zukünftigen Einsatz von Zielvereinbarungen im Krankenhaus.
Methodik Die Analyse basiert auf einer empirischen Auswertung der von der Koordinierungsstelle „Zielvereinbarungen in Chefarztverträgen“ bewerteten Zulässigkeit von Zielvereinbarungen sowie auf einer konzeptionellen Auseinandersetzung mit den Problembereichen der zulässigen Zielvereinbarungen aus der Perspektive des Krankenhauses.
Ergebnisse Während leistungsbezogene Zielvereinbarungen von der Koordinierungsstelle „Zielvereinbarungen in Chefarztverträgen“ als nicht akzeptabel angesehen werden, sind andersartige Zielvereinbarungen aus der Perspektive des Krankenhauses ebenfalls als problembehaftet einzustufen.
Schlussfolgerung Aufgrund der regulatorischen Vorgaben sind die möglichen Zielvereinbarungen als zu einseitig zu beurteilen, da sie die Ziele des Krankenhauses nicht in ihrer Gesamtheit wiedergeben. Unter Beachtung der regulatorischen Vorgaben erscheint die Nutzung von Zielvorgaben als Personalführungsinstrument als nicht zweckmäßig.
Multimode optomechanical system in the quantum regime
Authors: Nielsen William Hvidtfelt Padkær , Tsaturyan Yeghishe , Møller Christoffer Bo , Polzik Eugene S. , Schliesser Albert 
Published: December 2016

Significance
Optomechanics is the field of research studying the interaction of light and mechanical motion of mesoscopic objects. Recently, the quantum mechanical character of this interaction has been of particular interest. So far, experimental research, especially in the quantum regime, has focused on canonical systems with only one optical and mechanical degree of freedom—or mode—, respectively. In this work, we introduce a simple and robust optomechanical system featuring many, highly coherent mechanical modes. We evidence and investigate strong quantum correlations in this system, generated by the presence of this multitude of mechanical modes. This represents a key step toward multimode quantum optomechanics, which offers richer dynamics, new quantum phenomena, and a more accurate representation of real-world mechanical sensors.
Block models and personalized PageRank
Authors: Kloumann Isabel M. , Ugander Johan , Kleinberg Jon 
Published: December 2016

SignificanceMethods based on PageRank have been fundamental to work on identifying communities in networks, but, to date, there has been little formal basis for the effectiveness of these methods. We establish a surprising connection between the personalized PageRank algorithm and the stochastic block model for random graphs, showing that personalized PageRank, in fact, provides the optimal geometric discriminant function for separating the communities in stochastic block models over a wide class of functions. Building on this result, we develop stronger classifiers that, although scalable, are competitive with computationally much more demanding methods such as belief propagation.
Chiral twist drives raft formation and organization in membranes composed of rod-like particles
Authors: Kang Louis , Lubensky Tom C. 
Published: December 2016

Significance
Chiral objects are different from their mirror images and have properties that are physically forbidden for achiral objects. We show theoretically how one of these properties, the preference for chiral rods to adopt twisted configurations, generates an array of rafts in membranes formed by rod-like particles. Our theory can predict the composition, size, and interactions of these rafts based on measurable attributes of the rods, and its agreement with experimental data from a virus-based system supports its validity. Moreover, it proposes a mechanism for the stabilization of rafts in cell membranes, which are composed of chiral molecules. These lipid rafts are hypothesized to have important biological functions, and their manipulation may rely on a command of molecular chirality.
Jung’s psychoid concept: an hermeneutic understanding
Authors: Addison Ann 
Published: December 2016

ABSTRACTJung’s psychoid concept is not one of his most widely published ideas but it is one of his most fundamental, and his thinking on the subject occupied him for most of his career. Theoretically, he grounded the concept in the history of vitalism, but his ideas also had hermeneutic origins, in his self-experimentation and active imagination, as described in The Red Book. This paper reviews such hermeneutic background, and its value for informing a clinically relevant understanding of the psychoid concept.
Generalized food deception
Authors: Johnson Steven D. , Schiestl Florian P. 
Published: December 2016

AbstractThe majority of rewardless plant species are not specific mimics of the flowers of other species; instead, they deploy a generalized set of floral signals to attract pollinators. These generalized food-deceptive (GFD) species have a number of unique evolutionary and ecological properties that are discussed in this chapter. The success of GFD plants needs to be understood in light of the fact that flower-visiting animals regularly encounter reward-depleted flowers during their foraging bouts. The evolutionary strategy of GFD species succeeds because the process whereby flower visitors learn to avoid deceptive species is sometimes slow and uncertain and depends on a number of factors. Most of the known GFD species are orchids, but the principles outlined in this chapter apply broadly to other deceptive plant–pollinator interactions and underline the relative ease by which plants can manipulate food-seeking insects.
Virgil’s First Patron
Authors: Syme Ronald 
Published: December 2016

Abstract
The paper provides a full discussion of the place of Asinius Pollio in Virgil’s early work and of the connection between the poet and Maecenas. Virgil’s early work is set within the context of Triumviral Italy and of the political turmoil of the period. Much use is made, often in a heavily critical way, of the evidence provided by the late antique commentators of Virgil. The main contention of this study is that the development of Virgil’s political allegiances may be traced by a close reading of the work that he produced between the late forties and the early thirties of the first century bc.
Biomartr: genomic data retrieval with R
Authors: Drost Hajk-Georg , Paszkowski Jerzy 
Published: December 2016

Abstract

Motivation
Retrieval and reproducible functional annotation of genomic data are crucial in biology. However, the current poor usability and transparency of retrieval methods hinders reproducibility. Here we present an open source R package, biomartr, which provides a comprehensive easy-to-use framework for automating data retrieval and functional annotation for meta-genomic approaches. The functions of biomartr achieve a high degree of clarity, transparency and reproducibility of analyses.

Results
The biomartr package implements straightforward functions for bulk retrieval of all genomic data or data for selected genomes, proteomes, coding sequences and annotation files present in databases hosted by the National Center for Biotechnology Information (NCBI) and European Bioinformatics Institute (EMBL-EBI). In addition, biomartr communicates with the BioMart database for functional annotation of retrieved sequences. Comprehensive documentation of biomartr functions and five tutorial vignettes provide step-by-step instructions on how to use the package in a reproducible manner.

Availability and Implementation
The open source biomartr package is available at https://github.com/HajkD/biomartr and https://cran.r-project.org/web/packages/biomartr/index.html.

Supplementary information
Supplementary data are available at Bioinformatics online.
Capsaicin 8% Patch Repeat Treatment in Nondiabetic Peripheral Neuropathic Pain
Authors: Gálvez Rafael , Navez Marie-Louise , Moyle Graeme , Maihöfner Christian , Stoker Malcolm , Ernault Etienne , Nurmikko Turo J. , Attal Nadine 
Published: December 2016

Objectives:
To investigate the long-term safety and tolerability of capsaicin 8% patch repeat treatment in nondiabetic patients with peripheral neuropathic pain.

Methods:
A prospective, open-label, observational study in patients with postherpetic neuralgia, posttraumatic or postsurgical nerve injury, HIV-associated distal sensory polyneuropathy, or other peripheral neuropathic pain, and average daily pain score ≥4, who received ≤6 capsaicin 8% patch treatments over 52 weeks according to clinical need (retreatment at 9 to 12 wk intervals). Sensory testing and analgesic effectiveness were assessed using “bedside tests” and Brief Pain Inventory (question 5).

Results:
Overall, 306 patients received treatment. Treatment-emergent adverse events (TEAEs) and drug-related TEAEs were reported by 252 (82.4%) and 207 (67.6%) patients. Application site pain was the most common drug-related TEAE (n=112, 36.6%); no drug-related serious TEAEs were reported. Sensory category shift analyses from baseline to end of study (EoS) in patients attending at least 2 sensory visits (n=278 for all tests except warm, n=277) found sensory deterioration/loss in at least 1 modality in 50.4% (n=140); deterioration/loss in 1, 2, 3, 4, or 5 modalities occurred in 26.6% (n=74), 14.0% (n=39), 5.8% (n=16), 2.5% (n=7), and 1.4% (n=4) cases. Newly emergent hyperesthesia or allodynia was apparent in 1.1% to 3.6% of the cases (depending on modality) by EoS. Between 25.2% and 32.0% of patients reported improvement in a sensory modality by EoS. Average daily pain was 6.6 and 4.7 at baseline and month 12.

Conclusions:
Generally, capsaicin 8% patch repeat treatment over 52 weeks was well tolerated, with variable alteration in sensory function and minimal chance of complete sensory loss.
Repair of Large Abdominal Wall Defects Using Total Anterior Aponeurotic Flap: Anatomical Feasibility Study and Comparison with Ramirez’s Technique
Authors: Staszewicz Wojciech , Assalino Michela , Morel Philippe , Fasel Jean H. D. , Stimec Bojan V. , Tobalem Mickael 
Published: December 2016

Summary:
In this cadaveric study, we explored the feasibility of a maximal mobilization of the superficial abdominal fascia, in a continuous flap, to achieve a tension-free covering of midline defects. The aponeurosis of the external oblique muscle was incised along the anterior axillary line and then detached up to the anterior rectus sheath. The latter was opened between the external and the internal oblique aponeurosis while keeping the continuity with the external oblique fascia. The obtained flap was solid and uninterrupted. The width gain reached 15 ± 3 cm on each sides, providing tissue advancement 60% longer than Ramirez’s technique (n = 8). The described technique allows large covering with respect to the anatomical planes. Further clinical tests should evaluate the validity of such concept in the repair of giant and asymmetrical hernias.
The Use of a Hyaluronic Acid–Carboxymethylcellulose Membrane as an Adhesion Barrier during Nipple Delay before Nipple-preserving Mastectomy
Authors: Lamelas Andreas M. , Jablonka Eric M. , Harmaty Marco A. , Torina Philip J. 
Published: December 2016

Summary:
The desire for nipple-preserving mastectomies has increased over the past decade as studies have proven that the procedure has comparable oncologic risk as a traditional mastectomy in both therapeutic and prophylactic cases. Partial or complete nipple necrosis is a well-known complication of this procedure with rates in the literature ranging between 1% and 9%. In high-risk patients, surgeons are performing a delay procedure before the mastectomy to help improve nipple vascularity and decrease necrosis rates. We present a technique of using a short-lasting bioresorbable hyaluronate–carboxymethylcellulose membrane (Seprafilm; Genzyme, Cambridge, Mass.) during the delay procedure as an interpositional sheet, which prevents adhesion of the anterior breast skin from the underlying gland to both block revascularization to improve nipple perfusion and prevent the need for redissection of the previously created plane during the final mastectomy.
Wet-Peeling Technique of Deep Anterior Lamellar Keratoplasty With Hypotonic Water and Blunt Dissection for Healed Hydrops
Authors: Zhao Zelin , Li Jinyang , Zheng Qinxiang , Lin Wei , Jhanji Vishal , Chen Wei 
Published: December 2016

Purpose:
To describe the surgical technique and outcomes of “wet-peeling” deep anterior lamellar keratoplasty (DALK) using sterile water and blunt dissection in cases with corneal scarring after healed corneal hydrops.

Methods:
Manual DALK using a “wet-peeling” technique was performed in 20 eyes of 20 consecutive patients with healed corneal hydrops between June 2011 and October 2013.

Results:
Intraoperative microperforations were encountered in 2 (10%) cases. None of the cases required conversion to penetrating keratoplasty. There was significant improvement in mean best-corrected visual acuity at the end of 24 months postoperatively (0.99 ± 0.30 logMAR vs. 0.20 ± 0.11 logMAR; P < 0.001). The postoperative mean residual stromal bed thickness was 48.9 ± 5.9 μm, and mean central corneal thickness was 557.2 ± 50.3 μm. The mean endothelial density was 2021 ± 236 cells/mm2 at the final follow-up.

Conclusions:
Manual DALK using sterile water can be successfully performed in corneas with healed hydrops. Favorable visual outcomes may be attributed to thin residual bed thickness postoperatively.
Associations Between Spatial and Temporal Contrast Sensitivity and Reading
Authors: Brussee Tamara , van den Berg Thomas J. T. P. , van Nispen Ruth M. A. , van Rens Ger H. M. B. 
Published: December 2016

ABSTRACT

Purpose
To gain insight into the association between optical and neural components of contrast sensitivity (CS), operationalized as spatial CS (optical and neural) or temporal CS (solely neural), and reading speed in a clinical sample of healthy adults of various ages. Furthermore, precision and agreement of the two methods were assessed.

Methods
The Mars test and the temporal CS implementation of the C-Quant device were used to measure spatial CS and temporal CS, respectively. Tests were performed with 71 normally sighted adults: mean age 55 (range 18–86) years. Pearson’s correlation analyses were performed between spatial CS or temporal CS, and reading speed and partial correlations controlled for age are presented. Precision of the measurement was defined by the coefficient of repeatability and repeated measures standard deviations. Differences between spatial CS and temporal CS values were determined with 95% limits of agreement.

Results
A correlation was found between reading speed and both spatial CS (r = 0.470; P < .001) and temporal CS (r = 0.258; P = .04); partial correlations controlled for age were r = 0.175 (P = .17) and r = 0.152 (P = .24), respectively. Coefficient of repeatability was 0.13 log units and 0.24 log units for spatial CS and temporal CS test, respectively. A proportional difference of 0.1 log units was found between spatial CS and temporal CS measurements.

Conclusions
A significant correlation was found between both spatial CS and temporal CS and reading speed indicating that, besides optical components, neural aspects may be important in defining reading speed. The stronger correlation between spatial CS and reading speed is suggested to reflect a deterioration of both optical and neural factors with increasing age. The coefficients of repeatability for spatial CS and temporal CS found in the present study are in agreement with previous research, and the difference found between the two methods might be attributed to the psychometric differences between the methods.
Reconstruction of the Irradiated Breast: A National Claims-Based Assessment of Postoperative Morbidity
Authors: Chetta Matthew D. , Aliu Oluseyi , Zhong Lin , Sears Erika D. , Waljee Jennifer F. , Chung Kevin C. , Momoh Adeyiza O. 
Published: December 2016

Background:
Implant-based reconstruction rates have risen among irradiation-treated breast cancer patients in the United States. This study aims to assess the morbidity associated with various breast reconstruction techniques in irradiated patients.

Methods:
From the MarketScan Commercial Claims and Encounters database, the authors selected breast cancer patients who had undergone mastectomy, irradiation, and breast reconstruction from 2009 to 2012. Demographic and clinical treatment data, including data on the timing of irradiation relative to breast reconstruction were recorded. Complications and failures after implant and autologous reconstruction were also recorded. A multivariable logistic regression model was developed with postoperative complications as the dependent variable and patient demographic and clinical variables as independent variables.

Results:
Four thousand seven hundred eighty-one irradiated patients who met the inclusion criteria were selected. A majority of the patients [n = 3846 (80 percent)] underwent reconstruction with implants. Overall complication rates were 45.3 percent and 30.8 percent for patients with implant and autologous reconstruction, respectively. Failure of reconstruction occurred in 29.4 percent of patients with implant reconstruction compared with 4.3 percent of patients with autologous reconstruction. In multivariable logistic regression, irradiated patients with implant reconstruction had two times the odds of having any complication and 11 times the odds of failure relative to patients with autologous reconstruction.

Conclusions:
Implant-based breast reconstruction in the irradiated patient, although popular, is associated with significant morbidity. Failures of reconstruction with implants in these patients approach 30 percent in the short term, suggesting a need for careful shared decision-making, with full disclosure of the potential morbidity.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, III.