bluuebunny/crossref_metadata_2025_split huggingface dataset:
ICD – Primärprävention: Was ist neu?
Authors: Bettin Markus , Reinke Florian , Köbe Julia , Eckardt Lars 
Published: June 2017

ZusammenfassungDie Primärprävention des plötzlichen Herztods bleibt eine große Herausforderung. Verschiedene Studien konnten eine Risikoreduktion für den plötzlichen Herztod bei Patienten mit hochgradig eingeschränkter linksventrikulärer Funktion nach Myokardinfarkt und bei Patienten mit Herzinsuffizienz zeigen. Die aktuellen ECS-Leitlinien diskutieren intensiv die Indikationen für eine Primärprävention. Ein Großteil der zur Verfügung stehenden Daten ist verhältnismäßig alt und neue Daten stellen den Nutzen der ICD-Primärprävention bei Patienten mit z. B. dilatativer Kardiomyopathie infrage. Die Identifikation der Patienten, die tatsächlich von der primärprophylaktischen ICD-Implantation profitieren, ist eine wesentliche zukünftige Aufgabe.
Using two-alternative forced choice tasks and Thurstone’s law of comparative judgments for code-switching research
Authors: Stadthagen-González Hans , López Luis , Parafita Couto M. Carmen , Párraga C. Alejandro 
Published: June 2017

Abstract
This article argues that 2-alternative forced choice tasks and Thurstone’s law of comparative judgments (Thurstone, 1927) are well suited to investigate code-switching competence by means of acceptability judgments. We compare this method with commonly used Likert scale judgments and find that the 2-alternative forced choice task provides granular details that remain invisible in a Likert scale experiment. In order to compare and contrast both methods, we examined the syntactic phenomenon usually referred to as the Adjacency Condition (AC) (apud Stowell, 1981), which imposes a condition of adjacency between verb and object. Our interest in the AC comes from the fact that it is a subtle feature of English grammar which is absent in Spanish, and this provides an excellent springboard to create minimal code-switched pairs that allow us to formulate a clear research question that can be tested using both methods.
Comparison of Size, Terminal Fall Velocity, and Density of Bighead Carp, Silver Carp, and Grass Carp Eggs for Use in Drift Modeling
Authors: George Amy E. , Garcia Tatiana , Chapman Duane C. 
Published: June 2017

AbstractInvasive Asian carp established in the United States spawn in the turbulent water of rivers, and their eggs and early larvae develop while drifting in the current. The eggs, which are believed to perish if they settle before hatching, are slightly denser than water and are held in suspension by water turbulence. It is possible to use egg drift modeling to assess the capability of a river to support the survival of Asian carp eggs. Detection of spawning and estimation of egg abundance in the drift are typically assessed by ichthyoplankton trawls. Correct sampling design and interpretation of trawl data require knowledge of the vertical distribution of eggs in the drift, which can be accomplished with particle transport models. Data that are required to populate models of egg drift and vertical distribution include physical properties of assessed rivers and information on egg size, density, and terminal fall velocity, but data on these egg characteristics have not been previously available. Physical characteristics of the eggs are presented as a function of postfertilization time. We recorded mean egg diameter and terminal fall velocity for eggs from each Asian carp species during the first 5 h of development and at approximately 12 and 22 h postfertilization. Eggs of all species reached their maximum size before 4 h. Water‐hardened eggs of Silver Carp Hypophthalmichthys molitrix and Grass Carp Ctenopharyngodon idella were similarly sized in our trials, and water‐hardened eggs of Bighead Carp H. nobilis were the largest. After water hardening, Silver Carp eggs sank slowest, and Bighead Carp eggs sank fastest. For a given species, smaller‐diameter eggs generally had faster terminal fall velocities and higher specific gravity than larger eggs. We provide regression models of egg density and diameter for all three species, discuss usage of these data in modeling the drift and dispersion of Asian carp eggs, and discuss implications for egg sampling design.Received December 1, 2015; accepted March 20, 2017 Published online June 20, 2017
Key comparison BIPM.RI(I)-K6 of the standards for absorbed dose to water of the VSL, Netherlands and the BIPM in accelerator photon beams
Authors: Picard S , Burns D T , Roger P , Prez L A de , Jansen B J , Pooter J A 
Published: June 2017

A comparison of the dosimetry for accelerator photon beams was carried out between the Dutch Metrology Institute (VSL) and the Bureau International des Poids et Mesures (BIPM) from 23 September to 20 October 2014. The comparison was based on the determination of absorbed dose to water for three radiation qualities of the medical accelerator facilities of the National Physical Laboratory (United Kingdom). After establishing Draft B, the VSL discovered an error in the calculation of the correction factor for excess-heat linked to the VSL glass vessel used in the measurements at the NPL. The comparison results for the revised standard, reported as ratios of the VSL and the BIPM evaluations (and with the combined standard uncertainties given in parentheses), are 0.9959 (54) at 6 MV, 0.9958 (64) at 10 MV and 0.9991 (75) at 25 MV. This result is part of the on-going BIPM.RI(I)-K6 series of comparisons.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
New Patterns of the Two-Dimensional Rogue Waves: (2+1)-Dimensional Maccari System*
Authors: Wang Gai-Hua , Wang Li-Hong , Rao Ji-Guang , He Jing-Song 
Published: June 2017

Abstract

The ocean rogue wave is one kind of puzzled destructive phenomenon that has not been understood thoroughly so far. The two-dimensional nature of this wave has inspired the vast endeavors on the recognizing new patterns of the rogue waves based on the dynamical equations with two-spatial variables and one-temporal variable, which is a very crucial step to prevent this disaster event at the earliest stage. Along this issue, we present twelve new patterns of the two-dimensional rogue waves, which are reduced from a rational and explicit formula of the solutions for a (2+1)-dimensional Maccari system. The extreme points (lines) of the first-order lumps (rogue waves) are discussed according to their analytical formulas. For the lower-order rogue waves, we show clearly in formula that parameter b
2
plays a significant role to control these patterns.
The Minimal Clinically Important Difference of the Anterior Skull Base Nasal Inventory-12
Authors: Gravbrot Nicholas , Kelly Daniel F , Milligan John , Griffiths Chester F , Barkhoudarian Garni , Jahnke Heidi , White William L , Little Andrew S 
Published: June 2017

Abstract

BACKGROUND
The minimal clinically important difference (MCID) is defined as the smallest change in health-related quality of life (QOL) that patients consider meaningful. The MCID is essential for determining clinically significant changes, rather than simply statistically significant changes, in QOL scores. The Anterior Skull Base Nasal Inventory-12 (ASK Nasal-12), a site-specific sinonasal QOL instrument, has emerged as a standard instrument for assessing QOL in patients who have undergone endonasal transsphenoidal surgery.

OBJECTIVE
To determine the MCID for the ASK Nasal-12.

METHODS
Distribution- and anchor-based methods were used to determine the MCID for the ASK Nasal-12 based on raw data from a multicenter prospective QOL study of 218 patients.

RESULTS
Two distribution-based statistical methods, the one-half standard deviation method and the effect-size method, both yielded MCIDs of 0.37 (medium effect). The first anchor-based method, using the 2-wk postoperative overall nasal functioning item as the anchor, yielded an MCID of 0.31. The second anchor-based method, using the 2-wk postoperative Short Form Health Survey 8 bodily pain item as the anchor, yielded an MCID of 0.29.

CONCLUSION
The largest MCID obtained for the ASK Nasal-12 using 4 statistical methods 2 wk postoperatively was 0.37. This information provides clinicians with an essential context for determining the clinical significance of changes in QOL scores after interventions. Our results will help clinicians better interpret QOL scores and design future studies that are powered to detect meaningful QOL changes.
No Impact of Preadmission Anti-Inflammatory Drug Use on Risk of Depression and Anxiety After Critical Illness*
Authors: Medici Clara R. , Gradus Jaimie L. , Pedersen Lars , Sørensen Henrik T. , Østergaard Søren D. , Christiansen Christian F. 
Published: June 2017

Objectives:
Risk of depression and anxiety is elevated after intensive care. Drugs with anti-inflammatory properties may have antidepressant and anxiolytic effects. The aim of this study was to investigate the association between preadmission use of drugs with anti-inflammatory effects and risk of new-onset depression and anxiety among adult patients admitted to an ICU.

Design:
Propensity score–matched, population-based cohort study.

Setting:
All ICUs in Denmark from 2005 to 2013.

Patients:
Adults receiving mechanical ventilation in an ICU.

Interventions:
None.

Measurements and Main Results:
A total of 48,207 ICU patients were included. Exposures were preadmission single-agent or combined use of statins, nonsteroidal anti-inflammatory drugs, or glucocorticoids. Outcomes were cumulative incidence (risk) and risk ratio of new-onset psychiatrist-diagnosed depression or anxiety or prescriptions for antidepressants or anxiolytics. Propensity score matching yielded 6,088 statin user pairs, 2,886 nonsteroidal anti-inflammatory drug user pairs, 1,440 glucocorticoid user pairs, and 1,743 combination drug user pairs. The cumulative incidence of anxiety and depression during the 3 years following intensive care was 18.0% (95% CI, 17.0–19.0%) for statin users, 21.3% (95% CI, 19.8–22.9%) for nonsteroidal anti-inflammatory drug users, 17.4% (95% CI, 15.4–19.5%) for glucocorticoid users, and 19.0% (95% CI, 16.3–20.2%) for combination users. The cumulative incidence was similar in nonusers compared with users in all drug groups. The risk ratio of depression and anxiety 3 years after admission to ICU was 1.04 (95% CI, 0.96–1.13) for statin users, 1.00 (95% CI, 0.90–1.11) for nonsteroidal anti-inflammatory drug users, 0.97 (95% CI, 0.82–1.14) for glucocorticoid users, and 1.05 (95% CI, 0.90–1.21) for combination users, compared with nonusers. Results were consistent across subgroups (gender, age, preadmission diseases, type of admission) and sensitivity analyses (depression and anxiety separately).

Conclusions:
Preadmission use of statins, nonsteroidal anti-inflammatory drugs, glucocorticoids, or combinations did not alter the risk of depression and anxiety after critical illness.
Predictors of Local Recurrence in Patients With Myxofibrosarcoma
Authors: Odei Bismarck , Rwigema Jean-Claude , Eilber Frederick R. , Eilber Fritz C. , Selch Michael , Singh Arun , Chmielowski Bartosz , Nelson Scott D. , Wang Pin-Chieh , Steinberg Michael , Kamrava Mitchell 
Published: June 2017

Objectives:
Myxofibrosarcoma (MFS) is reported to have a higher risk of local recurrence (LR) following definitive surgical excision relative to other soft tissue sarcomas. We reviewed our clinical experience treating MFS to investigate predictors of LR.

Materials and Methods:
We retrospectively reviewed treatment outcomes for MFS patients treated at our institution between 1999 and 2015. A total of 52 patients were identified. Median age was 65 years (range, 21 to 86 y). Site of disease was: upper extremity (27%), lower extremity (46%), trunk (15%), pelvic (8%), and head and neck (4%). Patients had low, intermediate, high-grade, and unknown grade in: 23%, 8%, 67%, and 2% of tumors, respectively. Tumors were categorized as ≤5 cm (35%), >5 cm (56%), or unknown size (9%). In total, 71% received radiotherapy: 19% preoperative, 50% postoperative, and 2% both. All patients underwent surgery. Margins were negative in 71%, close/positive in 21%, and unknown in 8%. In total, 27% of patients received chemotherapy. Univariate Cox regression analysis was utilized to determine associations between clinical and treatment factors with LR.

Results:
Median follow-up time was 2.9 years (range, 0.4 to 14.3 y). The 3-year actuarial LR, distant metastasis, and overall survival were: 31%, 15%, and 87%, respectively. Predictors of LR were patient age greater than or equal to the median of 65 years (hazard ratio, 13.46, 95% confidence interval, 1.71-106.18, P=0.013), and having close/positive tumor margins (hazard ratio, 3.4, 95% confidence interval, 1-11.53, P=0.049).

Conclusions:
In this institutional series of MFS older age and positive/close margins were significantly associated with a higher risk of LR.
Parent Education is Changing
Authors: Davis Deborah Winders , Logsdon M. Cynthia , Vogt Krista , Rushton Jeff , Myers John , Lauf Adrian , Hogan Felicia 
Published: June 2017

Abstract

Purpose:
The purpose was to critique existing parenting apps using established criteria and health literacy guidelines.

Study Design:
Descriptive methodology was used.

Methods:
The Apple App Store was searched using the terms parenting, child health, and infant health. To be included, the apps had to have relevant content (parenting, child health, or infant health), be in English, and contain parent education. After eliminating apps that failed to meet inclusion criteria from the original 203 apps, 46 apps were reviewed. The Patient Education Materials Assessment Tool was used to evaluate the health literacy subscales called Understandability and Actionability. Content analysis included Authority, Objectivity, Accuracy, Timeliness, and Usability.

Results:
The majority of the apps (70%) were in English only. The price ranged from free to $4.99. The purpose, target audience, and topics varied. Although all included apps were for parents, some were for more targeted groups of parents. The source of the information was not presented in 26% of the apps. Most apps took the user to a Web site or an article to read. Functionality of the apps was limited, with none of them providing a customized experience.

Clinical Implications:
Much development and research is needed before mobile health (mHealth) solutions can be recommended by nurses caring for new parents. It is critical that consumers and interdisciplinary professionals be involved in the early design phase of the product to ensure that the end product is acceptable and usable and that it will lead to healthy behaviors.
Prevalence and Predictors of Posttraumatic Stress and Depression Symptoms Among Syrian Refugees in a Refugee Camp
Authors: Acarturk Ceren , Cetinkaya Mustafa , Senay Ibrahim , Gulen Birgul , Aker Tamer , Hinton Devon 
Published: June 2017

Abstract
Turkey is hosting the majority of Syrian refugees. The current study investigates the prevalence of probable posttraumatic stress disorder (PTSD) and depression among adult Syrians residing in a camp (N = 781) and potential predictors. The Impact of Event Scale–Revised was used to measure PTSD and the Beck Depression Inventory depression. Probable PTSD prevalence was 83.4%, with predictors being female sex (odds ratio [OR], 4.1), previous mental health problems (OR, 4.5), life threat (OR, 3.0), and injury of a loved one (OR, 1.8). Probable depression prevalence was 37.4%, with predictors being female sex (OR, 5.1), previous mental health problems (OR, 2.9), having a loved one who was tortured (OR, 1.7), and not being satisfied at the camp (OR, 1.7). The current study reveals high rates of probable PTSD and depression among Syrian refugees and highlights vulnerabilities such as great risk for women of having psychopathology.
Childhood Precursors of the Narcissistic Personality
Authors: Cramer Phebe 
Published: June 2017

Abstract
This research identifies the childhood personality characteristics that predict the presence of narcissism in adulthood. Using data from the longitudinal study of Block and Block (The California Child Q-set. Palo Alto, CA: Consulting Psychologists Press, 1980), childhood personality characteristics were assessed at age 11 (N = 100) using the California Child Q-set. A number of these were shown to differentially predict the presence of grandiose or vulnerable narcissism at age 23. Factor analyses of the Child Q-set items showed that the presence of Grandiose Narcissism was positively related to childhood factors representing social presence and negatively related to planfulness. In contrast, vulnerable narcissism was positively related to childhood impulsivity and negatively related to stable self-esteem. Both types of narcissism were positively related to childhood factors representing need for control.
High Prevalence of Concurrent Male-Male Partnerships in the Context of Low Human Immunodeficiency Virus Testing Among Men Who Have Sex With Men in Bamako, Mali
Authors: Hakim Avi , Patnaik Padmaja , Telly Nouhoum , Ballo Tako , Traore Bouyagui , Doumbia Seydou , Lahuerta Maria 
Published: June 2017

Background
Concurrent male-male sexual partnerships have been understudied in sub-Saharan Africa and are especially important because human immunodeficiency virus (HIV) prevalence and acquisition probability are higher among men who have sex with men (MSM) than among heterosexual men and women.

Methods
We conducted a respondent-driven sampling survey of 552 men who have sex with men in Bamako, Mali from October 2014 to February 2015. Eligibility criteria included 18 years or older, history of oral or anal sex with another man in the last 6 months, residence in or around Bamako in the last 6 months, ability to communicate in French.

Results
HIV prevalence was 13.7%, with 86.7% of MSM with HIV unaware of their infection. Concurrent male-male sexual partnerships were common, with 60.6% of MSM having a concurrent male sexual partnerships or believing their sex partner did in the last 6 months, and 27.3% having a concurrent male sexual partnerships and believing their sex partner did in the last 6 months. Over half (52.5%) of MSM had sex with women, and 30.8% had concurrent male partnerships and sex with a woman in the last 6 months. Concurrency was more likely among MSM with limited education, telling only MSM of same-sex behaviors, high social cohesion, and not knowing anyone with HIV.

Conclusions
The high proportion of HIV-infected MSM in Bamako who are unaware of their HIV infection and the high prevalence of concurrent partnerships could further the spread of HIV in Bamako. Increasing testing through peer educators conducting mobile testing could improve awareness of HIV status and limit the spread of HIV in concurrent partnerships.
Itraq-Based Quantitative Proteomic Analysis of Lungs in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment
Authors: Bian Yingxue , Qin Chao , Xin Yuchang , Yu Yang , Chen Hongguang , Wang Guolin , Xie Keliang , Yu Yonghao 
Published: June 2017

ABSTRACT
Sepsis-associated acute lung injury (ALI), which carries a high morbidity and mortality in patients, has no effective therapeutic strategies to date. Our group has already reported that hydrogen gas (H2) exerts a protective effect against sepsis in mice. However, the molecular mechanisms underlying H2 treatment are not fully understood. This study investigated the effects of H2 on lung injuries in septic mice through the isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomic analysis. Male ICR mice used in this study were subjected to cecal ligation and puncture (CLP) or sham operation. And 2% H2 was inhaled for 1 h beginning at 1 and 6 h after sham or CLP operation. The iTRAQ-based liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis was preformed to investigate lung proteomics. Sepsis-challenged animals had decreased survival rate, as well as had increased bacterial burden in blood, peritoneal lavage, and lung sample, which were significantly ameliorated by H2 treatment. Moreover, a total of 4,472 proteins were quantified, and 192 differentially expressed proteins were related to the protective mechanism of H2 against sepsis. Functional enrichment analysis showed that H2-related differential proteins could be related to muscle contraction, oxygen transport, protein synthesis, collagen barrier membranes, cell adhesion, and coagulation function. These proteins were significantly enriched in four signaling pathways, and two of which are associated with coagulation. In addition, H2 alleviates ALI in septic mice through downregulating the expression of Sema 7A, OTULIN, and MAP3K1 as well as upregulating the expression of Transferrin. Thus, our findings provide an insight into the mechanism of H2 treatment in sepsis by proteomic approach, which may be helpful to the clinic application of H2 in patients with sepsis.
Early fever after trauma: Does it matter?
Authors: Hinson Holly E. , Rowell Susan , Morris Cynthia , Lin Amber L. , Schreiber Martin A. 
Published: June 2017

BACKGROUND
Fever is strongly associated with poor outcome after traumatic brain injury (TBI). We hypothesized that early fever is a direct result of brain injury and thus would be more common in TBI than in patients without brain injury and associated with inflammation.

METHODS
We prospectively enrolled patients with major trauma with and without TBI from a busy Level I trauma center intensive care unit (ICU). Patients were assigned to one of four groups based on their presenting Head Abbreviated Injury Severity Scale scores: multiple injuries: head Abbreviated Injury Scale (AIS) score greater than 2, one other region greater than 2; isolated head: head AIS score greater than 2, all other regions less than 3; isolated body: one region greater than 2, excluding head/face; minor injury: no region with AIS greater than 2. Early fever was defined as at least one recorded temperature greater than 38.3°C in the first 48 hours after admission. Outcome measures included neurologic deterioration, length of stay in the ICU, hospital mortality, discharge Glasgow Outcome Scale-Extended, and plasma levels of seven key cytokines at admission and 24 hours (exploratory).

RESULTS
Two hundred sixty-eight patients were enrolled, including subjects with multiple injuries (n = 59), isolated head (n = 97), isolated body (n = 100), and minor trauma (n = 12). The incidence of fever was similar in all groups irrespective of injury (11–24%). In all groups, there was a significant association between the presence of early fever and death in the hospital (6–18% vs. 0–3%), as well as longer median ICU stays (3–7 days vs. 2–3 days). Fever was significantly associated with elevated IL-6 at admission (50.7 pg/dL vs. 16.9 pg/dL, p = 0.0067) and at 24 hours (83.1 pg/dL vs. 17.1 pg/dL, p = 0.0025) in the isolated head injury group.

CONCLUSION
Contrary to our hypothesis, early fever was not more common in patients with brain injury, though fever was associated with longer ICU stays and death in all groups. Additionally, fever was associated with elevated IL-6 levels in isolated head injury.

LEVEL OF EVIDENCE
Prognostic and Epidemiological study, level III.