bluuebunny/crossref_metadata_2025_split huggingface dataset:
Copy number loss in the region of the ASPN gene in patients with acetabular dysplasia
Authors: Sekimoto T. , Ishii M. , Emi M. , Kurogi S. , Funamoto T. , Yonezawa Y. , Tajima T. , Sakamoto T. , Hamada H. , Chosa E. 
Published: July 2017

Objectives We have previously investigated an association between the genome copy number variation (CNV) and acetabular dysplasia (AD). Hip osteoarthritis is associated with a genetic polymorphism in the aspartic acid repeat in the N-terminal region of the asporin (ASPN) gene; therefore, the present study aimed to investigate whether the CNV of ASPN is involved in the pathogenesis of AD. Methods Acetabular coverage of all subjects was evaluated using radiological findings (Sharp angle, centre-edge (CE) angle, acetabular roof obliquity (ARO) angle, and minimum joint space width). Genomic DNA was extracted from peripheral blood leukocytes. Agilent’s region-targeted high-density oligonucleotide tiling microarray was used to analyse 64 female AD patients and 32 female control subjects. All statistical analyses were performed using EZR software (Fisher’s exact probability test, Pearson’s correlation test, and Student’s t-test). Results CNV analysis of the ASPN gene revealed a copy number loss in significantly more AD patients (9/64) than control subjects (0/32; p = 0.0212). This loss occurred within a 60 kb region on 9q22.31, which harbours the gene for ASPN. The mean radiological parameters of these AD patients were significantly worse than those of the other subjects (Sharp angle, p = 0.0056; CE angle, p = 0.0076; ARO angle, p = 0.0065), and all nine patients required operative therapy such as total hip arthroplasty or pelvic osteotomy. Moreover, six of these nine patients had a history of operative or conservative therapy for developmental dysplasia of the hip. Conclusions Copy number loss within the region harbouring the ASPN gene on 9q22.31 is associated with severe AD. A copy number loss in the ASPN gene region may play a role in the aetiology of severe AD. Cite this article: T. Sekimoto, M. Ishii, M. Emi, S. Kurogi, T. Funamoto, Y. Yonezawa, T. Tajima, T. Sakamoto, H. Hamada, E. Chosa. Copy number loss in the region of the ASPN gene in patients with acetabular dysplasia: ASPN CNV in acetabular dysplasia. Bone Joint Res 2017;6:439–445. DOI: 10.1302/2046-3758.67.BJR-2016-0094.R1.
Digitale Archivierung im Hessischen Landesarchiv
Authors: Schieber Sigrid 
Published: July 2017

Zusammenfassung
Am Beispiel eines deutschen Staatsarchivs, das 2011 mit der digitalen Archivierung begonnen hat, versucht dieser Artikel die wesentlichen Herausforderungen der digitalen Archivierung in einem typischen Archiv herauszuarbeiten. Da wir nach wie vor am Anfang dieser Aufgabe stehen, liegt der Fokus auf der Übernahme digitalen Materials (Ingest) – wie kann archivwürdiges digitales Material ausfindig gemacht werden, wie wird es in archivfähige Dateiformate und Datenstrukturen übertragen, wie werden die Integrität der Daten und der Datenschutz bei der Datenübermittlung sichergestellt etc. Der Artikel konzentriert sich dabei auf drei Formen digitaler Unterlagen: strukturierte Informationen aus Datenbanken, elektronische Akten und Dateiablagen und endet mit einem Exkurs zu den Fragen der Erhaltung und (späteren) Nutzung dieser Unterlagen.
Contested Practice: Political Activism in Nursing and Implications for Nursing Education
Authors: Buck-McFadyen Ellen , MacDonnell Judith 
Published: July 2017

AbstractCanadian nurses have a social mandate to address health inequities for the populations they serve, as well as to speak out on professional and broader social issues. Although Canadian nursing education supports the role of nurses as advocates for social justice and leadership for health care reform, little is known about how nurse educators understand activism and how this translates in the classroom. A comparative life history study using purposeful sampling and a critical feminist lens was undertaken to explore political activism in nursing and how nurse educators foster political practice among their students. Findings from interviews and focus groups with 26 Ontario nurse educators and nursing students suggested that neoliberal dynamics in both the practice setting and in higher education have constrained nurses’ activist practice and favour a technical rational approach to nursing education. Implications and strategies to inspire political action in nursing education are discussed.
Multinodular goiter in children: treatment controversies
Authors: García-García Emilio , López-González Mercedes , Cabello-Laureano Rosa , Navarro-González Elena 
Published: July 2017

AbstractBackground:Multinodular goiter (MG) is very common in adults. MG may occur in children in some exceptional circumstances. The objective of this study was to examine two cases of MG in children who relapsed soon after surgery and to discuss the treatment options in pediatric ages.Methods:Two girls consulted for euthyroid colloid goiter, uninodular goiter and bilateral MG. They were intervened by hemithyroidectomy and total thyroidectomy, respectively, due to the existence of local symptoms.Results:Goiters reappeared 3 years after intervention in both cases. They already appeared as bilaterally MG, and patients underwent a total thyroidectomy, in one case after 1 year of treatment with levothyroxine (LT4).Conclusions:MG treatment remains controversial. There is an increasing trend to a more radical surgery decreasing recurrence risk. Treatment with LT4 may be tested but it is rarely effective. Regardless of the therapeutic option, these children should be followed up and they should know about the possibility of goiter regeneration and the need for reintervention.
Concentrations of leptin, adiponectin and other metabolic parameters in non-obese children with Down syndrome
Authors: Tenneti Nikhil , Dayal Devi , Sharda Sheetal , Panigrahi Inusha , Didi Mohammed , Attri Savita Verma , Sachdeva Naresh , Bhalla Anil Kumar 
Published: July 2017

AbstractBackground:Recent data indicates that adults with Down syndrome (DS) are at increased risk for cardiovascular disease (CVD) that significantly contributes to their morbidity and mortality. Although identification of cardiometabolic risk factors during childhood is desirable to design preventive interventions, the data on such risk factors in children with DS is scarce. The aim of this study was to study the cardiometabolic risk factors such as insulin resistance (IR), leptin and adiponectin concentrations, lipid abnormalities and leptin resistance in non-obese children with DS.Methods:This cross-sectional case control study included karyotype confirmed trisomy-21 DS children aged 2–12 years and their matched healthy controls. After detailed anthropometry, weight, height and body mass index (BMI) standard deviation scores (SDSs) were calculated with reference data. Laboratory evaluation included determination of fasting lipid parameters, insulin, glucose, leptin and adiponectin concentrations. The homeostasis model assessment method (HOMA-IR) was used to assess IR and the ratio of leptin to BMI was used as an index of leptin resistance.Results:Seventy-seven children (39 with DS and 38 controls) comprised the study cohort. The anthropometric parameters were similar in the two groups. Children with DS showed significantly higher mean leptin concentrations (2.098±1.68 ng/mL vs. 1.44±0.52 ng/mL, p-value: 0.00) and higher indices of leptin resistance (0.127±0.085 vs. 0.09±0.03, p-value: 0.001) as compared to controls. Fasting adiponectin concentrations were lower (20.64±19.87 ng/mL vs. 32.58±34.25 ng/mL, p-value: 0.21) and fasting glucose higher (89.25±8.12 mg/dL vs. 85.71±5.52 mg/dL, p-value: 0.06) in the DS group as compared to the controls but the differences did not reach statistical significance. The concentrations of insulin, various lipid parameters and calculated HOMA-IR values were similar in the two groups. In the DS group, five children were identified to have high (>75th centile) leptin levels and four as impaired fasting glucose as compared to none in the controls.Conclusions:Alterations of several cardiometabolic risk factors, in particular, leptin concentrations and leptin resistance are present in children with DS. The presence of hyperleptinemia without hyperinsulinemia suggests a probable inherent genetic basis for increased leptin resistance in patients with DS. There is a need for larger studies to further understand increased leptin resistance in DS that may contribute to increased CVD related morbidity and mortality in these patients.
Manners of Performing Terrorist Attacks
Authors: Bąk Tomasz 
Published: July 2017

Abstract
The article below presents the evolution of terrorist tactics over the years. It describes the basic types of terrorist attacks divided by the place of attack and by means used to execute it. The recent ways of performing terrorist attacks by terrorist organizations have been presented on the basis of accessible sources and statistics. The last part of the article is dedicated to expected changes of terrorist attack tactics in the future.
Constellation of Cubesats to Monitor the Environment for the Benefit of Europe
Authors: Dimitrov Ivan , Dimitrov Miroslav , Baev Georgi 
Published: July 2017

Abstract
In our project we are going to present a concept for the creation, launching, usage and exploiting of an innovative system of semi-autonomous, grouped in “swarm” satellites from one type with 24/7 link to Earth-based facilities and stations for control, transfer and analysis of space-gathered data. The innovation in our mission is the usage of a group of apparatuses that can work both like a structured group with one directed goal or like a loosely-chained system of autonomous machines, each with a different task or mission given by the control center on Earth.
Modern Approaches in the Training of Military Police Cadets at Vassil Levski National Military University
Authors: Krastev Krastyu 
Published: July 2017

Abstract
The mission of the Vasil Levski National Military University is to build its students morally, mentally and physically, to indoctrinate them with the ideals of patriotism, duty and honour, to form them as individuals and leaders. The graduated students have to possess leadership qualities, be able to develop and apply scientific knowledge, manage public and special structures in peacetime and crises and to participate in national and multinational projects aiming at maintaining security, peace and development of society. The present paper describes some results of the implementation of the modern person centered educational approaches to training of the Military police cadets.
Security, Defence and Armed Forces - Public View
Authors: Libor Frank 
Published: July 2017

Abstract
The paper deals with the interpretation of public opinion polls in the Czech Republic related to security, defence and armed forces. In recent years, we can observe concern about the security situation development in the relatively close vicinity of the Czech Republic. In particular, information regarding the activities of the so-called Islamic State, the conflict in Ukraine and media presentation of recent terrorist attacks, as well as the dominant securitization of migration, have a major impact on the public opinion and the level of support for specific steps of the government in the field of security and defence policy. In the surveys, we can trace not only the growing public concern, but also the increasing support for higher defence spending and possible reintroduction of some form of compulsory military service. Special attention is paid to the public perception of the armed forces and the interpretation of the latest public opinion polls at the turn of 2016/2017. The growing support for the military and the increasing willingness of the public to engage in the Active Reserve System are positive factors that can be used to meet the recruiting goals of the Czech Armed Forces.
Criteria Determination for Obstacle Effectivenes Evaluation
Authors: Palasiewicz Tibor , Kyjovský Jan 
Published: July 2017

Abstract
Up to date concept of warfare is characterized by a high mobility of units, in spite of this counter-mobility is currently disregarded. However, military engineers try to keep and develop this capability. One of the most important elements for the development in the field of counter-mobility is man-made obstacles effectiveness evaluation. The process of evaluation is applicable to the obstacle employment design, to the estimation of a battle progress as well as to the development of mine-laying means, including mines and explosives for obstacle creating. The article is focused on determination of the appropriate obstacles effectiveness evaluation criteria. The criteria can be applied within planning of barriers as well as other complexes of obstacles (obstacle areas, zones, belts), which allows to optimize the engagement of engineer units and means to fulfil the engineer tasks.
Diplomacy and Security
Authors: Pop Ștefan 
Published: July 2017

Abstract
Changes in diplomacy are especially visible by the involvement of many new actors in the area of international cooperation. A fast developing international system opened doors to many new actors, including international organizations, transnational corporations, and important interest groups.Diplomacy that, from the middle of the 15th century, was known as an important tool of foreign policy became wider in the post-Cold War era. In fact, the transformation of diplomacy has not been completed yet. Nowadays, for instance, governmental diplomacy must deal with various nonstate actors that shape its agenda.
Brexit – Major Consequences on the Process of European Military Integration?
Authors: Pricopi Marius 
Published: July 2017

Abstract
The United Kingdom’s choice to withdraw from the European Union (Brexit) took many by surprise, including a good part of the „Leave“ voters. The repercussions of this vote are in full display and affect each and every area of the community life. Considering different indicators (such as the number of troops deployed by the United Kingdom to military operations conducted by the European Union or the British contributions to the Battlegroups), in this paper we submit to analysis the United Kingdom’s stance in the process of military integration within the European Union in the period before the Brexit Referendum (2011-2015); we mainly argue that - although regrettable - Brexit will not significantly affect the day-to-day activities and projects conducted within the Common Security and Defence Policy.
Intelligence Preparation of the Battlefield as a Part of Knowledge Development
Authors: Skalický Pavel , Palasiewicz Tibor 
Published: July 2017

Abstract
The aim of this article is to introduce an approach to intelligence preparation of the battlefield (IPB) as a part of knowledge development in conditions of the Army of the Czech Republic (ACR). Numerous of NATO publications and Stanags has been analyzed as well as Czech national documents. Based on results of the analyses and personal experience of authors, the current state of IPB applied in ACR has been outlined and main imperfections of this process have been emphasized such as a disregard of dynamic changes of terrain in time and so on. It the closing section of the article a few possible ways of IPB development have been suggested. Those suggestions show possible form of this process for needs in 21st century.
The Drones and Issues Connected with Their Use in Contemporary Conflicts
Authors: Stojar Richard 
Published: July 2017

Abstract
The text deals with the development and methods of use of Drones or Unmanned Aerial Vehicles in contemporary conflicts or special operations. The contribution tries to present the main advantages of these vehicles as being the main reasons for their current use in armed forces of state as well as non-state actors and their dynamic proliferation in global space in past years. We can observe a new trend in the armed conflict in the last two decades - use of advanced systems of unmanned vehicles in such a range that many military and academic experts talk about a new wave of revolutionary changes in the military affairs. This wave, or we could even talk about militarytechnological breakthrough should lead to imminent use of these systems in contemporary as well as future conflicts which would result in the partial or complex robotization of the battlefield. Specific attention is dedicated to controversies tied to the use of Drones/Unmanned Aerial Vehicles in socalled Drone Warfare and current discussion in the context of cultural or societal dimension of their use and perspectives for further development.
Considerations on the Necessity of Modernization of Engineer Forces from NATO Members Countries
Authors: Vladu Mircea , Popa Ioan-Dan 
Published: July 2017

Abstract
The engineer branch has been established at a certain stage of historical evolution of the armed forces to provide engineer support to the combat forces, as well as to support civil societies to achieve, develop and maintain the necessary infrastructure elements in order to conduct of economic and social activities. Having in mind all these elements and taking into account the structural perspective and the endowment, the evolution of engineer forces should have been made in accordance with the evolution of the common combat joint forces, keeping the same rhythm of development. Unfortunately, the engineer forces within the armies of the NATO member states did not evolve under the aforementioned aspects, even if some commitments have been made at the various summits held over time at different levels. As a result of these realities, in this paper we present some considerations about what should be the way ahead in the evolution of the engineer forces until the horizon of 2050.
The Role of Computer Systems in the Management of Hotels in Veliko Tarnovo Region, Bulgaria
Authors: Mancheva-Ali Olga , Dimitrova Vanya 
Published: July 2017

Abstract
This study presents the essence, importance and role of hotel computer systems used in Veliko Tarnovo region. The attached questionnaire presents a method of analyzing systems and their role in the management process. The study shows the most used local systems, their advantages and disadvantages and possible steps and recommendations for the improvement of their effectiveness.
Empirical Study Regarding the Influence of Communication Upon the Purchasing Decision
Authors: Popescu Dan , Dinu Alina , State Cristina , Picu Cătălina 
Published: July 2017

Abstract
The aim of the present study is to emphasize the influence of communication upon the customer’s purchasing decision. This objective is translated through determining the change of products in the sales’ structure using communication by omission. The study is focused upon the purchasing selection between two similar products by the subjects included in the study. The difference between the two products lies in the customers’ care for the environment. Thus, one of the two products does not pollute, in the conditions in which the application with care and attention is applied (this being expressed through a price difference compared to the other, polluting, product). The study has two phases in order to compare the sales structure in the situations in which it is used the communication through omission (in the second phase of the study) with the sales structure when the communication through omission is not used. The hypothesis according to which the purchasing process takes place according to the care for the environment and not necessarily according to the direct utility allocated to some apparently similar products has been tested through econometric instruments.
Some Aspects Concerning The Communication in Multinational Corporations Existing on The Romanian Market
Authors: Niţă Monica , Stanciu Radu D. 
Published: July 2017

Abstract
The proposed topic presents a high interest at least from two points of view. Economically speaking, the multinational corporations define to a considerable extent the economic performance of Romania. As communication, these corporations with entire or prevailing foreign capital could be considered as models for what it means intercultural communication and cultural adapting. The research of the aspects connected to communication in an intercultural framework allows the drawing of some pertinent conclusions concerning the role of communication as a key factor of success or on the contrary an important barrier. At the same time, the approach of communication process needs not only the study of communication itself but also the mentalities, the attitudes, and the behaviors. The present paper refers mostly to internal communication and less to promotional communication. In the same time, it refers to the way act the organizational cultures existing in those corporations, if there is a closed connection between communication and organizational culture.
The International Image of Ion I. C. Brătianu in 1919
Authors: Calcan Gheorghe 
Published: July 2017

Abstract
Our paper aims to present how Ion I. C. Brătianu was perceived outside national borders in a very important moment of the Romanian national history, namely the international recognition of the Great Union, within the Peace Conference at Paris-Versailles in 1919 -1920. Ion I. C. Brătianu was at that moment Prime Minister and the leader of the Romanian delegation at Versailles. Foreign countries perceived him as a very powerful personality, capable to influence other states with similar interests in Central and South Eastern Europe. Brătianu stoutly and patriotically defended the Romanian interests. Therefore, although his position was correct, it came into conflict with the interests of the great powers. Brătianu would not give up his principles and decided to leave the Peace Conference. French media was objective in their accounts and proved favourable to the Romanian position.
A Study of Nutrition and The Nutritional Status of Servicemen, Assessed on The Basis of Anthropometric Indicators
Authors: Glushkov Pavlin Ivanov 
Published: July 2017

Abstract
The modern food industry has the potential to produce and offers "unlimited" quantities of all sorts tempting foods in response to the expectations of consumers. The development of powerful marketing and promotional campaigns in pursuance of the objective to boost sales creates the perfect conditions for the modification of the eating patterns of the population. In addition, this makes it possible for foods, whose everyday use would increase the risk of non-communicable diseases, to permanently find their place on the menu in every household.
A Preliminary Study of Empathy in Romanian College Students
Authors: Lupu Valentin 
Published: July 2017

Keywords
The Interpersonal Reactivity Index is a self-report instrument used for assessing empathy. The theoretical model of empathy for IRI assumes that empathy is multidimensional in nature containing affective aspects (Empathic Concern and Personal Distress) and cognitive aspects (Perspective Taking and Fantasy). The objective of this study was to compare the level of empathy in Romanian college students to the level of empathy in American college students and to compare empathy in college students based on gender and field of study. The IRI was administered to a sample of 216 Romanian college students. We were interested only on Empathic Concern and Perspective Taking scales. The results revealed that Empathic Concern in Romanian college students is lower than in American college students, women score higher than men on the two scales used and students studying at humanities colleges have a higher Perspective Taking than students studying at science colleges. Our suggestion as a result of this study is to introduce more classes in the curriculum at the elementary school level to teach children empathy using diverse methods.