bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural and Referent-Based Effects on Prosodic Expression in Russian
Authors: Luchkina Tatiana , Cole Jennifer S. 
Published: February 2017

AbstractThis study examines prosody in read productions of two published narratives by 15 Russian speakers. Two distinct sources of variation in acoustic-prosodic expression are considered: structural and referent-based. Structural effects refer to the particular linearization of words in a sentence or phrase. Referent-based effects relate to the semantic and pragmatic characteristics of the discourse referent of a word, and to grammatical roles that are partially dependent on referent characteristics. Here, we examine referent animacy and the related grammatical function of subjecthood, and the relative accessibility or information status of a word. We document patterns of prosodic augmentation and prosodic reduction due to structural and referent-based factors, as evident from change in values of acoustic-prosodic measures mean intensity, duration and f0 range. Prosodic augmentation due to structural effects is observed for words positioned ex-situ, independent of their semantic, grammatical or pragmatic features. Prosodic augmentation due to referent-based effects is observed for words that are grammatical subjects with animate referents. Prosodic expression is further affected by referent information status. Discourse-given and discourse-new information show greater prosodic augmentation than inferable information. A closer look at individual speakers' production styles reveals that structural and referent-based variations occur in combination and interact.
Perspectives on Speech Timing: Coupled Oscillator Modeling of Polish and Finnish
Authors: Malisz Zofia , O’Dell Michael , Nieminen Tommi , Wagner Petra 
Published: February 2017

AbstractThis stud y was ai med at analyzing empirical duration data for Polish spoken at different tempos using an updated version of the Coupled Oscillator Model of speech timing and rhythm variability (O'Dell and Nieminen, 1999, 2009). We use Bayesian inference on parameters relating to speech rate to investigate how tempo affects timing in Polish. The model parameters found are then compared with parameters obtained for equivalent material in Finnish to shed light on which of the effects represent general speech rate mechanisms and which are specific to Polish. We discuss the model and its predictions in the context of current perspectives on speech timing.
Identification of unique venous thromboembolism-susceptibility variants in African-Americans
Authors: Armasu Sebastian , McCauley Bryan , Kullo Iftikhar , Sicotte Hugues , Pathak Jyotishman , Chute Christopher , Gottesman Omri , Bottinger Erwin , Denny Joshua , Roden Dan , Li Rongling , Ritchie Marylyn D. , de Andrade Mariza , Heit John A. 
Published: February 2017

SummaryTo identify novel single nucleotide polymorphisms (SNPs) associated with venous thromboembolism (VTE) in African-Americans (AAs), we performed a genome-wide association study (GWAS) of VTE in AAs using the Electronic Medical Records and Genomics (eMERGE) Network, comprised of seven sites each with DNA biobanks (total ~39,200 unique DNA samples) with genome-wide SNP data (imputed to 1000 Genomes Project cosmopolitan reference panel) and linked to electronic health records (EHRs). Using a validated EHR-driven phenotype extraction algorithm, we identified VTE cases and controls and tested for an association between each SNP and VTE using unconditional logistic regression, adjusted for age, sex, stroke, site-platform combination and sickle cell risk genotype. Among 393 AA VTE cases and 4,941 AA controls, three intragenic SNPs reached genome-wide significance: LEMD3 rs138916004 (OR=3.2; p=1.3E-08), LY86 rs3804476 (OR=1.8; p=2E-08) and LOC100130298 rs142143628 (OR=4.5; p=4.4E-08); all three SNPs validated using internal cross-validation, parametric bootstrap and meta-analysis methods. LEMD3 rs138916004 and LOC100130298 rs142143628 are only present in Africans (1000G data). LEMD3 showed a significant differential expression in both NCBI Gene Expression Omnibus (GEO) and the Mayo Clinic gene expression data, LOC100130298 showed a significant differential expression only in the GEO expression data, and LY86 showed a significant differential expression only in the Mayo expression data. LEMD3 encodes for an antagonist of TGF-β-induced cell proliferation arrest. LY86 encodes for MD-1 which down-regulates the pro-inflammatory response to lipopolysaccharide; LY86 variation was previously associated with VTE in white women; LOC100130298 is a non-coding RNA gene with unknown regulatory activity in gene expression and epigenetics.Supplementary Material to this article is available online at www.thrombosis-online.com.
Severe Hypertriglyceridemia Induced by Sirolimus Treated With Medical Management Without Plasmapheresis: A Case Report
Authors: Kido Kazuhiko , Evans Rickey A. , Gopinath Anil , Flynn Jeremy D. 
Published: February 2017

Summary: Hypertriglyceridemia and hyperlipidemia are the most remarkable metabolic complications seen with long-term sirolimus therapy. We report the case of a 36-year-old woman status post bilateral lung transplantation on a maintenance immunosuppression regimen of sirolimus, tacrolimus, and prednisone who presented with status migrainosus, chest pain, abdominal discomfort, and triglyceride levels greater than 4425 mg/dL. In previously reported cases of severe hypertriglyceridemia that developed on maintenance sirolimus therapy, plasmapheresis has been utilized as an early strategy to rapidly lower triglycerides in order to minimize the risk of acute complications such as pancreatitis, but our case was managed medically without plasmapheresis. The most recent triglyceride was down to 520 mg/dL 2 months after discontinuation of sirolimus. We estimate the probability of this reaction to sirolimus as probable based on a score of 5 points on the Naranjo scale. This is the first case report to our knowledge that highlights the sole use of oral lipid-lowering drug agents to treat severe hypertriglyceridemia secondary to sirolimus without the use of plasmapheresis. Conclusion: Sirolimus-induced severe hypertriglyceridemia can be managed with oral lipid-lowering agents without plasmapheresis. Clinician needs to be aware of the importance of baseline and regular triglyceride monitoring in patients on sirolimus.
Relation between cathodoluminescence and trace-element distribution of magmatic topaz from the Ary-Bulak massif, Russia
Authors: Agangi Andrea , Gucsik Arnold , Nishido Hirotsugu , Ninagawa Kiyotaka , Kamenetsky Vadim S. 
Published: February 2017

AbstractIn order to define the cathodoluminescence (CL) properties of magmatic topaz and its relation with trace-element composition, we studied topaz phenocrysts from the Ary-Bulak ongonite massif, Russia using a wide array of analytical techniques. Scanning electron microscopy CL panchromatic images reveal strong variations, which define micrometre-scale euhedral growth textures. Several truncations of these growth textures occur in single grains implying multiple growth and resorption events. The CL-spectra of both CLbright and -dark domains have a major peak in the near-ultraviolet centred at 393 nm. Cathodoluminescence images taken after several minutes of electron bombardment show decreasing emission intensity. Electron microprobe analyses indicate high F concentrations (average OH/(OH + F) = 0.04 calculated by difference, 100 wt.% – total from electron probe microanalyses), consistent with what has been found previously in topaz-bearing granites, and the OH stretching vibration (∼3653 cm–1) was detected in Raman spectra. Laser ablation inductively-coupled plasma mass spectrometry traverses performed across the CL textures detected trace elements at ppm to thousands of ppm levels, including: Fe, Mn, Li, Be, B, P, Nb, Ta, W, Ti, Ga, light rare-earth elements, Th and U. Lithium, W, Nb and Ta appear to be correlated with CL intensity, suggesting a role for some of these elements in the activation of CL in topaz. In contrast, no clear correlation was found between CL intensity and F contents, despite the fact that the replacement of OH for F is known to affect the cell parameters of topaz.
From structure topology to chemical composition. XX. Titanium silicates: the crystal structure of hejtmanite, Ba2Mn4Ti2(Si2O7)2O2(OH)2F2, a Group-II TS-block mineral
Authors: Sokolova E. , Cámara F. , Hawthorne F. C. , Pautov L. A. 
Published: February 2017

AbstractThe crystal structure of hejtmanite, Ba2Mn4Ti2(Si2O7)2O2(OH)2F2, from Mbolve Hill, Mkushi River area, Central Province, Zambia (holotype material) has been refined on a twinned crystal to R1 = 1.88% on the basis of 4539 [|F| > 4|F|] reflections. Hejtmanite is triclinic, C1̅, a = 10.716(2), b = 13.795(3), c = 11.778 (2) , = 90.07(3), = 112.24(3), = 90.03(3), V = 1612(2) 3. Chemical analysis (electron microprobe) gives: Ta2O5 0.09, Nb2O5 1.27, ZrO2 0.65, TiO2 14.35, SiO2 23.13, BaO 26.68, SrO 0.19, FeO 11.28, MnO 15.12, Cs2O 0.05, K2O 0.33, F 3.82, H2Ocalc. 1.63, O = F 1.61, total 97.10 wt.%, where the H2O content was calculated from the crystal-structure refinement, with (OH F) = 4 apfu. The empirical formula, calculated on the basis of 20 (O F) anions, is of the form (Si2O7)2(XO)4(XP)2, Z=4: (Ba1.82K0.07 Sr0.02)Σ1.91(Mn2.33Zr0.04Mg0.03)Σ3.95(Ti1.88Nb0.10Zr0.02)Σ2(Si2.02O7)2O2[(OH)1.89 F0.11]Σ2F2. The crystal structure is a combination of a TS (Titanium Silicate) block and an I (intermediate) block. The TS block consists of HOH sheets (H heteropolyhedral, O octahedral). The topology of the TS block is as in Group-II TS-block minerals: Ti ( Nb) = 2 apfu per (Si2O7)2 [as defined by Sokolova (2006)]. In the O sheet, five [6]MO sites are occupied mainly by Mn, less Fe2 and minor Zr and Mg, with <MOφ> = 2.198 (φ = O,OH), ideally giving Mn4 apfu. In the H sheet, two [6]MH sites are occupied mainly by Ti, with <MHφ> = 1.962 (φ = O,F), ideally giving Ti2 apfu; four [4]Si sites are occupied by Si, with < SiO> = 1.625 . The MH octahedra and Si2O7 groups constitute the H sheet. The two [12]Ba-dominant AP(1,2) sites, with <APφ> = 2.984 (φ = O, F), ideally give Ba2 apfu. Two (1,2) and two (1,2) sites are occupied by O atoms and OH groups with minor F, respectively, ideally giving (XO)4 = ()2 ()2=O2(OH)2 pfu. Two (1,2) sites are occupied by F, giving F2 apfu. TS blocks link via a layer of Ba atoms which constitute the I block. Simplified and end-member formulae of hejtmanite are Ba2(Mn,Fe2)4Ti2 (Si2O7)2O2(OH,F)2 F2 and Ba2Mn4Ti2(Si2O7)2O2(OH)2F2, Z = 4. Hejtmanite is a Mn-analogue of bafertisite, Ba2 4 Ti2(Si2O7)2O2(OH)2F2.
The crystal structure of gianellaite, [(NHg2)2](SO4)(H2O)x, a framework of (NHg4) tetrahedra with ordered (SO4) groups in the interstices
Authors: Cooper M. A. , Abdu Y. A. , Hawthorne F. C. , Kampf Anthony R. 
Published: February 2017

AbstractThe crystal structure of gianellaite, [(NHg2)2](SO4)(H2O)x, cubic,F4̄3m, a = 9.521(6) ÅV= 863.1(1.6) Å3,Z= 4, was solved by direct methods and refined to anR1index of 2.1% based on 167 unique observed reflections collected on a three-circle rotating-anode (MoKα X-radiation) diffractometer equipped with multilayer optics and an APEX-II detector. In the structure of gianellaite, nitrogen-centred (NHg4)5+tetrahedra share all corners to form a framework of tetrahedra with an ordered arrangement of interstitial (SO4)2–tetrahedra that show strong orientational disorder. Infrared spectroscopy in the principal O–H stretching region shows peaks at ∼3300 and 1600 cm–1, indicating the presence of (H2O), the position(s) of which could not be discerned in difference-Fourier maps.
Crystal structure of adamite at high temperature
Authors: Zema M. , Tarantino S. C. , Boiocchi M. , Callegari A. M. 
Published: February 2017

AbstractStructural modifications with temperature of adamite, Zn2(AsO4)(OH), were determined by single-crystal X-ray diffraction up to dehydration and collapse of the crystal structure. In the temperature range 25–400°C, adamite shows positive and linear expansion. Axial thermal expansion coefficients, determined over this temperature range, are αa= 1.06(2) × 10–5K–1, αb= 1.99(2) × 10–5K–1, αc= 3.7(1) × 10–6K–1and αV= 3.43(3) × 10–5K–1. Axial expansion is then strongly anisotropic withαa:αb:αc= 2.86: 5.38 : 1. Structure refinements of X-ray diffraction data collected at different temperatures allowed us to characterize the mechanisms by which the adamite structure accommodates variations in temperature. Expansion is limited mainly by edge sharing Zn(2) dimers along a and by edge sharing Zn(1) octahedra chains along c; on the other hand, connections of polyhedra along b, the direction of maximum expansion, is governed by corner sharing. Increasing temperature induces mainly an axial expansion of Zn(1) octahedron, which becomes more elongated, and no significant variations of the Zn(2) trigonal bipyramids and As tetrahedra. Starting from 400°C, deviation from a linear evolution of unit-cell parameters is observed, associated with some deterioration of the crystal, a sign of incipient dehydration. The process leads to the formation of Zn4(AsO4)2O.
Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL
Authors: Erdmann Tabea , Klener Pavel , Lynch James T. , Grau Michael , Vočková Petra , Molinsky Jan , Tuskova Diana , Hudson Kevin , Polanska Urszula M. , Grondine Michael , Mayo Michele , Dai Beiying , Pfeifer Matthias , Erdmann Kristian , Schwammbach Daniela , Zapukhlyak Myroslav , Staiger Annette M. , Ott German , Berdel Wolfgang E. , Davies Barry R. , Cruzalegui Francisco , Trneny Marek , Lenz Peter , Barry Simon T. , Lenz Georg 
Published: February 2017

Key Points
PI3Kα/δ inhibition induces cytotoxicity in ABC DLBCLs through downregulation of NF-κB signaling. Inhibition of AKT induces cytotoxicity by downregulation of MYC in PTEN-deficient DLBCL models in vivo and in vitro.
A Role for Adrenergic Receptors in the Uterotonic Effects of Ergometrine in Isolated Human Term Nonlaboring Myometrium
Authors: Fanning Rebecca A. , Sheehan Florike , Leyden Claire , Duffy Niamh , Iglesias-Martinez Luis F. , Carey Michael F. , Campion Deirdre P. , O’Connor John J. 
Published: February 2017

BACKGROUND:
Ergometrine is a uterotonic agent that is recommended in the prevention and management of postpartum hemorrhage. Despite its long-standing use, the mechanism by which it acts in humans has never been elucidated fully. The objective of this study was to investigate the role of adrenoreceptors in ergometrine’s mechanism of action in human myometrium. The study examined the hypothesis that α-adrenoreceptor antagonism would result in the reversal of the uterotonic effects of ergometrine.

METHODS:
Myometrial samples were obtained from women undergoing elective cesarean delivery. The samples were then dissected into strips and mounted in organ bath chambers. After the generation of an ergometrine concentration–response curve (10–15 to 10–5 M), strips were treated with increasing concentrations of ergometrine (10–15 to 10–7 M) alone and ergometrine (10–7 to 10–5 M) in the presence of phentolamine (10–7 M), prazosin (10–7 M), propranolol (10–6 M), or yohimbine (10–6 M). The effects of adding ergometrine and the effect of drug combinations were analyzed using linear mixed effects models with measures of amplitude (g), frequency (contractions/10 min), and motility index (g×contractions/10 min).

RESULTS:
A total of 157 experiments were completed on samples obtained from 33 women. There was a significant increase in the motility index (adding 0.342 g × counts/10 min/μM; 95% confidence interval [CI], 0.253–0.431, P < .001), amplitude (0.078 g/μM; 95% CI, 0.0344–0.121, P = 5e-04), and frequency (0.051 counts/10 min/μM; 95% CI, 0.038–0.063, P < .001) in the presence of ergometrine. The α-adrenergic antagonist phentolamine and the more selective α1-adrenergic antagonist prazosin inhibited the ergometrine mediated increase in motility index, amplitude, and frequency (−1.63 g × counts/10 min/μM and −16.70 g × counts/10 min/μM for motility index, respectively).

CONCLUSIONS:
These results provide novel evidence for a role for α-adrenergic signaling mechanisms in the action of ergometrine on human myometrial smooth muscle in the in vitro setting. Information that sheds light on the mechanism of action of ergometrine may have implications for the development of further uterotonic agents.
A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells
Authors: Goicoechea Silvia M. , Zinn Ashtyn , Awadia Sahezeel S. , Snyder Kyle , Garcia-Mata Rafael 
Published: February 2017

ABSTRACT
One of the hallmarks of cancer is the ability of tumor cells to invade surrounding tissues and metastasize. During metastasis, cancer cells degrade the extracellular matrix, which acts as a physical barrier, by developing specialized actin-rich membrane protrusion structures called invadopodia. The formation of invadopodia is regulated by Rho GTPases, a family of proteins that regulates the actin cytoskeleton. Here, we describe a novel role for RhoG in the regulation of invadopodia disassembly in human breast cancer cells. Our results show that RhoG and Rac1 have independent and opposite roles in the regulation of invadopodia dynamics. We also show that SGEF (also known as ARHGEF26) is the exchange factor responsible for the activation of RhoG during invadopodia disassembly. When the expression of either RhoG or SGEF is silenced, invadopodia are more stable and have a longer lifetime than in control cells. Our findings also demonstrate that RhoG and SGEF modulate the phosphorylation of paxillin, which plays a key role during invadopodia disassembly. In summary, we have identified a novel signaling pathway involving SGEF, RhoG and paxillin phosphorylation, which functions in the regulation of invadopodia disassembly in breast cancer cells.
Oxidized phagosomal NOX2 complex is replenished from lysosomes
Authors: Dingjan Ilse , Linders Peter T. A. , van den Bekerom Luuk , Baranov Maksim V. , Halder Partho , ter Beest Martin , van den Bogaart Geert 
Published: February 2017

ABSTRACT
In dendritic cells, the NADPH oxidase 2 complex (NOX2) is recruited to the phagosomal membrane during antigen uptake. NOX2 produces reactive oxygen species (ROS) in the lumen of the phagosome that kill ingested pathogens, delay antigen breakdown and alter the peptide repertoire for presentation to T cells. How the integral membrane component of NOX2, cytochrome b558 (which comprises CYBB and CYBA), traffics to phagosomes is incompletely understood. In this study, we show in dendritic cells derived from human blood-isolated monocytes that cytochrome b558 is initially recruited to the phagosome from the plasma membrane during phagosome formation. Cytochrome b558 also traffics from a lysosomal pool to phagosomes and this is required to replenish oxidatively damaged NOX2. We identified syntaxin-7, SNAP23 and VAMP8 as the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins mediating this process. Our data describe a key mechanism of how dendritic cells sustain ROS production after antigen uptake that is required to initiate T cell responses.
Chenodeoxycholic acid stimulates glucagon‐like peptide‐1 secretion in patients after Roux‐en‐Y gastric bypass
Authors: Nielsen Signe , Svane Maria S. , Kuhre Rune E. , Clausen Trine R. , Kristiansen Viggo B. , Rehfeld Jens F. , Holst Jens J. , Madsbad Sten , Bojsen‐Moller Kirstine N. 
Published: February 2017

AbstractPostprandial secretion of glucagon‐like peptide‐1 (GLP‐1) is enhanced after Roux‐en‐Y gastric bypass (RYGB), but the precise molecular mechanisms explaining this remain poorly understood. Plasma concentrations of bile acids (BAs) increase after RYGB, and BAs may act as molecular enhancers of GLP‐1 secretion through activation of TGR5‐receptors. We aimed to evaluate GLP‐1 secretion after oral administration of the primary bile acid chenodeoxycholic acid (CDCA) and the secondary bile acid ursodeoxycholic acid (UDCA) (which are available for oral use) in RYGB‐operated participants. Eleven participants (BMI 29.1 ± 1.2, age 37.0 ± 3.2 years, time from RYGB 32.3 ± 1.1 months, weight loss after RYGB 37.0 ± 3.1 kg) were studied in a placebo‐controlled, crossover‐study. On three different days, participants ingested (1) placebo (water), (2) UDCA 750 mg, (3) CDCA 1250 mg (highest recommended doses). Oral intake of CDCA increased plasma concentrations of GLP‐1, C‐peptide, glucagon, peptide YY, neurotensin, total bile acids, and fibroblast growth factor 19 significantly compared with placebo (all P < 0.05 for peak and positive incremental area‐under‐the‐curve (piAUC)). All plasma hormone concentrations were unaffected by UDCA. Neither UDCA nor CDCA changed glucose, cholecystokinin or glucose‐dependent insulinotropic polypeptide (GIP) concentrations. In conclusion, our findings demonstrate that the primary bile acid chenodeoxycholic acid is able to enhance secretion of gut hormones when administered orally in RYGB‐operated patients—even in the absence of nutrients.
To report or not to report: a proposal on how to deal with altered test results in hemolytic samples
Authors: Cadamuro Janne , Mrazek Cornelia , Haschke-Becher Elisabeth , Sandberg Sverre 
Published: February 2017

Abstract
Preanalytically altered test results are a challenge every laboratory has to face. The release of such results may be to the harm of the patient by triggering wrong clinical decision making in monitoring or treatment. On the other hand, their deletion also might be to the harm of the patient by delaying the time to decision making as the exact value sometimes is not even necessary but rather an answer to the question “Is it raised or lowered”. Based on this dilemma and forced to produce laboratory values without any clinical information on the respective patient, laboratories have developed their own preferred way on how to deal with preanalytically altered test results. Some release the value with a comment, some reject the value with or without a comment and others again provide only general information about the hemolytic sample. To date there is no guideline or standardization to this postanalytical topic. Therefore, with this opinion paper, we want to start the scientific discussion on this important issue by providing one possible method to overcome the lack of clinical information which the laboratory would need to correctly decide whether or not to release an altered test result. We suggest providing the clinician with all the information on the hemolytic sample and its impact on the respective parameter needed to make his/her own decision on the usage of the respective test result. We believe that reporting a preanalytically altered laboratory value including a respective comment is preferable to not reporting it.