bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Disease Characteristics, Organ Damage, and Survival in Patients with Juvenile-onset and Adult-onset Systemic Lupus Erythematosus in a Combined Cohort from 2 Tertiary Centers in Turkey
Authors: Artim-Esen Bahar , Şahin Sezgin , Çene Erhan , Şahinkaya Yasemin , Barut Kenan , Adrovic Amra , Özlük Yasemin , Kılıçaslan Işın , Omma Ahmet , Gül Ahmet , Öcal Lale , Kasapçopur Özgür , İnanç Murat 
Published: March 2017

Objective.Age at onset has been shown to affect the clinical course and outcome of systemic lupus erythematosus (SLE). Herein, we aimed to define the differences in clinical characteristics, organ damage, and survival between patients with juvenile-onset (jSLE) and adult-onset SLE (aSLE).Methods.For the study, 719 patients (76.9%) with aSLE and 216 (23.1%) with jSLE were examined. Comparisons between the groups were made for demographic characteristics, clinical features, auto-antibody profiles, damage, and survival rates.Results.These results were significantly more frequent in jSLE: photosensitivity, malar rash, oral ulcers, renal involvement, neuropsychiatric (NP) manifestations, and autoimmune hemolytic anemia (AIHA). Of the autoantibodies, a higher frequency of anti-dsDNA and anticardiolipin IgG and IgM were observed in the jSLE group. A significant proportion of patients with aSLE had anti-Sm positivity and pleuritis. The proportion of patients with jSLE who developed organ damage was comparable to that of patients with aSLE (53% vs 47%) and the mean damage scores were similar in both groups. Renal damage was significantly more frequent in jSLE while musculoskeletal and cardiovascular system damage and diabetes mellitus were more prominent in aSLE. Comparison of survival rates of the 2 groups did not reveal any significant differences.Conclusion.We report a higher frequency in the jSLE group of renal involvement, cutaneous symptoms, oral ulcers, NP manifestations, AIHA, and anti-dsDNA positivity. A significant proportion of patients in the jSLE group had damage, most prominently in the renal domain. Our findings might support different genetic/environmental backgrounds for these 2 subgroups.
Ultrasound Evaluation of the Entheses in Daily Clinical Practice during Tumor Necrosis Factor-α Blocking Therapy in Patients with Ankylosing Spondylitis
Authors: Wink Fréke , Bruyn George A. , Maas Fiona , Griep Ed N. , van der Veer Eveline , Bootsma Hendrika , Brouwer Elisabeth , Arends Suzanne , Spoorenberg Anneke 
Published: March 2017

Objective.To assess structural and inflammatory ultrasound (US) lesions of entheses in ankylosing spondylitis (AS) patients with active disease and to evaluate inflammatory lesions after 6 months of tumor necrosis factor (TNF-α) blocking therapy, in daily clinical practice.Methods.Consecutive patients with AS were clinically evaluated and underwent US examination of 9 bilateral entheses before and after 6 months of TNF-α blocking therapy. US examination included the following as inflammatory lesions: bone erosions/cortical irregularities, enthesophytes, calcifications as structural lesions; adjacent bursitis, effusion, increased tendon hypoechogenicity or thickness; and positive power Doppler (PD) signal.Results.At baseline, 105 (95%) of 111 included patients showed US abnormalities. Structural lesions were seen in 74 patients (67%) and inflammatory lesions in 88 (79%). Enthesophytes and positive PD signal were the most prevalent structural and inflammatory lesions, respectively. Most lesions were found at the lower extremities. Additionally, inflammatory lesions occurred at the lateral epicondyle of the elbow. Patients with structural lesions at baseline were significantly older, had longer disease duration, higher modified Stoke AS Spine score, and higher C-reactive protein. Individually, there was a great diversity in changes of inflammatory entheseal lesions during treatment, but on the group level no significant decrease was found.Conclusion.This prospective observational cohort study in daily clinical practice shows a high prevalence of structural and inflammatory US lesions in AS patients with longstanding and active disease. Positive PD signal was the most common inflammatory feature. No significant change in inflammatory US lesions was found after 6 months of TNF-α blocking therapy.
OMERACT Quality-adjusted Life-years (QALY) Working Group: Do Current QALY Measures Capture What Matters to Patients?
Authors: Trenaman Logan , Boonen Annelies , Guillemin Francis , Hiligsmann Mickael , Hoens Alison , Marra Carlo , Taylor Will , Barton Jennifer , Tugwell Peter , Wells George , Bansback Nick 
Published: March 2017

Objective.To understand the limitations with current patient-reported outcome measures (PROM) used to generate quality-adjusted life-years (QALY) in rheumatology, and set a research agenda.Methods.Two activities were undertaken. The first was a scoping review of published studies that have used PROM to generate QALY in rheumatology between 2011 and 2016. The second was an interactive “eyeball test” exercise at Outcome Measures in Rheumatology 13 that compared subdomains of widely used generic PROM, as identified through the scoping review, to subdomains of the Assessment of SpondyloArthritis Health Index (ASAS-HI) condition-specific PROM for ankylosing spondylitis.Results.The scoping review included 39 studies. Five different PROM have been used to generate QALY in rheumatology; however, the EQ-5D and Short Form 6 Dimensions (SF-6D) were used most frequently (in 32 and 9 of included studies, respectively). Special interest group participants identified energy/drive and sleep as 2 key subdomains of the ASAS-HI instrument that may be missed by the EQ-5D, and sexual function as potentially missed by the SF-6D. Participants also expressed concerns that aspects of the process of care and non-health outcomes may be missed. Three ways of incorporating additional subdomains were discussed, including using an alternative generic PROM, modifying an existing generic PROM with “bolt-on” subdomain(s), and generating societal weights for a condition-specific PROM.Conclusion.Three priorities for future research were identified: understanding whether the EQ-5D and SF-6D identify what matters to patients with different rheumatic conditions, analyzing how much patients value process or non-health outcomes, and identifying which approaches to incorporating a greater number of subdomains into the QALY are being undertaken in other disease areas.
Comment le genre s’invite dans nos cabinets
Authors: Blanc Élise 
Published: March 2017

Cet article s’appuie sur les aspects théoriques développés dans la première partie : « Le genre, regard de psy » paru dans ce même numéro. « Il s’agit de construire une posture de thérapeute martien capable d’écouter et de comprendre nos patients dans des zones restées jusqu’à présent invisibles », écrit Élise Blanc à la fin de cette première partie. Cette posture est ici largement interrogée et analysée à l’aide de concepts d’analyse transactionnelle. Où mettre le curseur entre le sain, le pathologique et la norme ? Comment respecter la demande du patient en laissant de côté nos préjugés et croyances ? Comment concilier visée thérapeutique et éthique ? Une vignette clinique enrichit notre réflexion déjà bien sollicitée par le contenu de cet écrit. F.H.
« Désolée, je ne peux rien pour vous »
Authors: Le Berre Rozenn 
Published: March 2017

Manque de personnel, stress au travail, absence de pause, heures supplémentaires non récupérées, risques psychosociaux non pris en compte… Pour les salarié·e·s travaillant dans des structures d’aide aux étrangers, la liste des entraves au droit du travail est longue. Et pourtant, peu de revendications émergent, chacun·e semblant accepter son sort sans broncher. Quand des voix s’élèvent, c’est souvent pour dénoncer les conditions d’accueil réservées aux étrangers, pas leurs conditions de travail. Témoignage d’une ex-travailleuse sociale employée au « tri des mineurs ».
Précarité en miroir au guichet de l’État social
Authors: Martin Pascal 
Published: March 2017

Avec la mise en place de la CMU, l’assurance maladie s’est vu confier une nouvelle mission : l’assistance, soit la prise en charge de bénéficiaires non cotisants. Pour faire face à l’arrivée de ces publics précaires, « étrangers » ou perçus comme tels, à ses guichets, sans obérer la « performance économique » de ce service public devenu « gestionnaire », le choix a été fait de sous-traiter l’assistance à des opérateurs privés. Avec des conséquences sur l’emploi et le service.
EVALUATING TWO RAINWATER HARVESTING SYSTEMS IN AN URBAN SETTING IN OREGON'S WILLAMETTE VALLEY
Authors: Olsen Conner , Kowalewski Alexander , Gould Micah , Lambrinos John 
Published: March 2017

INTRODUCTION The recent trend toward more extreme periods of drought has been a shock to the residents of the Pacific Northwest – many of whom have relied upon heavy wateruse in the summer months in order to make a living (i.e. producers of grass seed and sod, berries, or nursery crops), or to maintain their landscapes at high levels (i.e. certain homeowners, recreational facilities, or commercial properties). Furthermore, population growth has reached the point where even an average year of precipitation has proven insufficient for urbanities that had not previously experienced issues with water scarcity (McDonald et al., 2011). This modern climate scenario has forced people of the Pacific Northwest, and people from all around the world, to rethink their water-use strategies, as the global trend has shifted toward greater sustainability (Tilman, 2001; McDonald et al., 2011). One potential mitigation strategy for cool-humid regions, such as Oregon's Willamette Valley, is to utilize rainwater-harvesting systems to alleviate freshwater demand (Kinkade-Levario, 2007). Rainwater harvesting is a logical choice for this climate zone because the average annual precipitation (42.7-in for Corvallis, OR) is sufficient for the majority of its crop production, however, this precipitation occurs almost exclusively in a nine-month period spanning from fall to spring (US Climate Data, 1981–2010). Although annual precipitation is adequate, irrigation is still required for at least three months of every year. This study considered rainwater harvesting to be ideally suited for the cool-humid Willamette Valley; the excess rainfall in the wet season that could be stored for use in the summer months, thus decreasing demand for municipal water by an equivalent amount. It should be stated that rainwater harvesting is not a novel idea; there have been studies dating back to the 1980's and earlier that have shown significant watersavings when retrofitting homes with new features like rainwater-harvesting systems (Boers et al., 1982, Karpisack et al., 1990). Even before that, golf courses, sporting complexes, and industrial sites alike were making use of this strategy. However, their methods typically consisted of catching rainwater via surface runoff and storing it in retention ponds (Ferguson, 1998), which is a strategy that is less applicable to the small-acreage homeowner who wants to irrigate their property without having to turn half of their backyard into a pond. Fortunately, there are alternative methods of rainwater harvesting that make a lot more sense in a residential setting, where irrigated land is small in relation to the roof-area for which rain can be easily harvested. This study documents the construction of two distinct rainwater-harvesting systems (an aboveground cistern and a belowground AQUABLOX™ matrix storage system), and gives insight into their advantages and disadvantages.
THE WALWORTH ALTERNATIVE: RETAINING AND ENHANCING BRITAIN'S SOCIAL HOUSING ESTATES UTILISING CONTEMPORARY TIMBER CONSTRUCTION
Authors: Kane Mike , Yee Ron 
Published: March 2017

INTRODUCTION This paper describes the research designs of London South Bank University (LSBU) Masters of Architecture students who investigated the future housing needs of expanding cities, focusing in detail on the Walworth area of South London as a potential model for application elsewhere. The students then proposed innovative ideas on how to expand and remodel the Aylesbury Housing Estate through the use of contemporary timber construction without resorting to wholescale demolition. The study is part of ongoing research into resource efficient architecture and planning by the M. Arch - Resource Studio 22 tutored by Mike Kane and Ron Yee at LSBU. The field of study was inspired by the Metsäwood's Plan B research program of case studies on iconic buildings, such as the Empire State Building in New York and the Colosseum in Rome, that re-engineered them in timber. (a) During the study period LSBU with the support of Metsäwood organised the “Urban Wood” seminar where 3 renowned architects were invited to speak about building advanced engineered timber buildings within dense urban London locations.
MULTIFAMILY AFFORDABLE HOUSING THAT IS HEALTHY, EFFICIENT, COST EFFECTIVE AND LEED PLATINUM
Authors: Grant Sharon Patterson 
Published: March 2017

INTRODUCTION A developer who had chronic asthma as a child built the first LEED® (Leadership in Energy and Environmental Design) Platinum certified apartment complex in Idaho. He has also heard from two residents that their asthma no longer resulted in attacks due to eliminating triggers in the interior environment. Eight years and a dozen multifamily affordable housing projects later, the LEED consultant on these projects has gathered insight on best practices, lessons learned and strategies that result in resident, owner and project team satisfaction. Ten projects have achieved LEED Platinum certification (two more are still under construction, but are on track for Platinum), and the HERS (Home Energy Rating System) scores are as low as 48. Feedback has been collected on what works, what doesn't and what matters most: from low energy bills to living in a healthy home and not having asthma attacks. These projects debunk the assumptions that energy efficiency adds too much cost or that green homes are only for the wealthy.
BUILDING PERFORMANCE SIMULATION AS AN EARLY INTERVENTION OR LATE VERIFICATION IN ARCHITECTURAL DESIGN: SAME PERFORMANCE OUTCOME BUT DIFFERENT DESIGN SOLUTIONS
Authors: Xie Xiaohuan , Gou Zhonghua 
Published: March 2017

INTRODUCTIONCurrent green building practice has been largely advanced by an integrated design process. This integrated design process involves multiple disciplines, such as architecture, civil, mechanical, and electrical engineering. The design method heavily relies on utilizing building performance simulation to illustrate how design parameters affect the energy consumption and quality of the indoor environment before actual design decisions are made (Anderson, 2014). The architectural design tools in the integrated design process supersede traditional geometrical exploration instruments, such as Sketchup, Revit, ArchiCad, and Rhino (Negendahl, 2015). More building performance simulating tools, such as Ecotect, Computational Fluid Dynamics (CFD), Radiance, and EnergyPlus, have been developed to help architects measure building performance (e.g., natural ventilation, daylighting, solar radiation, and energy uses) in the design process and attain green building standards such as Leadership in Energy and Environmental Design (LEED). The information presented by these tools guide architects at a certain level in achieving green building goals. However, building simulation is generally beyond the architect's knowledge domain. Many architects have difficulty in understanding these technical terms and models, as well as their design implications. Therefore, specific consultants have emerged to help architects grasp the meanings of these numbers and models, which require architects to implement a high level of design collaboration and coordination (Aksamija, 2015; Gou & Lau, 2014). Simulation consultants can work in parallel with architects at the early design stage to intervene in the conceptual and schematic design; they may also work behind architects to verify the building performance after the design is finished and make their design green through technical alterations.Most existing literature argues for an early intervention of building performance simulation in the architectural design process and explores different algorithms or models for optimal intervention (Degens, Scholzen, & Odenbreit, 2015; Sick, Schade, Mourtada, Uh, & Grausam, 2014; Svetlana Olbina & Yvan Beliveau, 2007). However, the difference between early intervention and late verification is often not investigated. Few qualitative studies can help understand how the building performance simulation is actually implemented, and how it influences the quality of design solutions in addition to the quantity of performance outcomes. The current research presents two case studies that compare building performance simulation as an early intervention and a late verification tool in the architectural design process, which contextualizes the building simulation research in real building practices.
The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages
Authors: Hannemann Nicole , Jordan Jutta , Paul Sushmita , Reid Stephen , Baenkler Hanns-Wolf , Sonnewald Sophia , Bäuerle Tobias , Vera Julio , Schett Georg , Bozec Aline 
Published: March 2017

Abstract
Activation of proinflammatory macrophages is associated with the inflammatory state of rheumatoid arthritis. Their polarization and activation are controlled by transcription factors such as NF-κB and the AP-1 transcription factor member c-Fos. Surprisingly, little is known about the role of the AP-1 transcription factor c-Jun in macrophage activation. In this study, we show that mRNA and protein levels of c-Jun are increased in macrophages following pro- or anti-inflammatory stimulations. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment cluster analyses of microarray data using wild-type and c-Jun–deleted macrophages highlight the central function of c-Jun in macrophages, in particular for immune responses, IL production, and hypoxia pathways. Mice deficient for c-Jun in macrophages show an amelioration of inflammation and bone destruction in the serum-induced arthritis model. In vivo and in vitro gene profiling, together with chromatin immunoprecipitation analysis of macrophages, revealed direct activation of the proinflammatory factor cyclooxygenase-2 and indirect inhibition of the anti-inflammatory factor arginase-1 by c-Jun. Thus, c-Jun regulates the activation state of macrophages and promotes arthritis via differentially regulating cyclooxygenase-2 and arginase-1 levels.
Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity
Authors: Shah Nirav G. , Tulapurkar Mohan E. , Ramarathnam Aparna , Brophy Amanda , Martinez Ramon , Hom Kellie , Hodges Theresa , Samadani Ramin , Singh Ishwar S. , MacKerell Alexander D. , Shapiro Paul , Hasday Jeffrey D. 
Published: March 2017

AbstractThe p38 MAPK family is composed of four kinases of which p38α/MAPK14 is the major proinflammatory member. These kinases contribute to many inflammatory diseases, but the currently available p38 catalytic inhibitors (e.g., SB203580) are poorly effective and cause toxicity. We reasoned that the failure of catalytic p38 inhibitors may derive from their activity against noninflammatory p38 isoforms (e.g., p38β/MAPK11) and loss of all p38α-dependent responses, including anti-inflammatory, counterregulatory responses via mitogen- and stress-activated kinase (MSK) 1/2 and Smad3. We used computer-aided drug design to target small molecules to a pocket near the p38α glutamate–aspartate (ED) substrate-docking site rather than the catalytic site, the sequence of which had only modest homology among p38 isoforms. We identified a lead compound, UM101, that was at least as effective as SB203580 in stabilizing endothelial barrier function, reducing inflammation, and mitigating LPS-induced mouse lung injury. Differential scanning fluorimetry and saturation transfer difference–nuclear magnetic resonance demonstrated specific binding of UM101 to the computer-aided drug design–targeted pockets in p38α but not p38β. RNA sequencing analysis of TNF-α–stimulated gene expression revealed that UM101 inhibited only 28 of 61 SB203580-inhibited genes and 7 of 15 SB203580-inhibited transcription factors, but spared the anti-inflammatory MSK1/2 pathway. We provide proof of principle that small molecules that target the ED substrate-docking site may exert anti-inflammatory effects similar to the catalytic p38 inhibitors, but their isoform specificity and substrate selectivity may confer inherent advantages over catalytic inhibitors for treating inflammatory diseases.
The Induction of Pro–IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production
Authors: Zasłona Zbigniew , Pålsson-McDermott Eva M. , Menon Deepthi , Haneklaus Moritz , Flis Ewelina , Prendeville Hannah , Corcoran Sarah E. , Peters-Golden Marc , O’Neill Luke A. J. 
Published: March 2017

Abstract
PGE2 has been shown to increase the transcription of pro–IL-1β. However, recently it has been demonstrated that PGE2 can block the maturation of IL-1β by inhibiting the NLRP3 inflammasome in macrophages. These apparently conflicting results have led us to reexamine the effect of PGE2 on IL-1β production. We have found that in murine bone marrow–derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1β transcription, as well as boosting the ability of LPS to induce IL-1β mRNA and pro–IL-1β while inhibiting the production of TNF-α. This results in an increase in mature IL-1β production in macrophages treated with ATP. We also examined the effect of endogenously produced PGE2 on IL-1β production. By blocking PGE2 production with indomethacin, we made a striking finding that endogenous PGE2 is essential for LPS-induced pro–IL-1β production, suggesting a positive feedback loop. The effect of endogenous PGE2 was mediated by EP2 receptor. In primary human monocytes, where LPS alone is sufficient to induce mature IL-1β, PGE2 boosted LPS-induced IL-1β production. PGE2 did not inhibit ATP-induced mature IL-1β production in monocytes. Because PGE2 mediates the pyrogenic effect of IL-1β, these effects might be especially relevant for the role of monocytes in the induction of fever. A positive feedback loop from IL-1β and back to PGE2, which itself is induced by IL-1β, is likely to be operating. Furthermore, fever might therefore occur in the absence of a septic shock response because of the inhibiting effect of PGE2 on TNF-α production.
Jovens estudantes e seus professores: Interação social e currículo dialógico
Authors: Vasconcelos Ivar César Oliveira de , Gomes Candido Alberto da Costa 
Published: March 2017

As mudanças da universidade têm levado a certa frustração quando o professor não consegue atender às exigências por informações atualizadas, ainda mais se este jáse conscientizou de que educar não ésóinformar, mas formar. Então, torna-se imperativa a articulação entre conteúdos e destes com valores. Por que tem predominado o currículo que prioriza aspectos informativos da educação, portanto, menos dialógico? Nesta perspectiva, investiga-se a interação entre experiências sociaisconstruídas por estudantes e professores, visando a compreender como concretizar, cada vez mais, o currículo dialógico. Um estudo de casos múltiplos revelou o hábito de culpar o outro pelo insucesso acadêmico, a negação da capacidade de crítica dos sujeitos e a tendência a cultivar relações autoritárias.