bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming
Authors: Gritti Ilaria , Wan Jinkai , Weeresekara Vajira , Vaz Joel M. , Tarantino Giuseppe , Bryde Tenna Holgersen , Vijay Vindhya , Kammula Ashwin V. , Kattel Prabhat , Zhu Songli , Vu Phuong , Chan Marina , Wu Meng-Ju , Gordan John D. , Patra Krushna C. , Silveira Vanessa S. , Manguso Robert T. , Wein Marc N. , Ott Christopher J. , Qi Jun , Liu David , Sakamoto Kei , Gujral Taranjit S. , Bardeesy Nabeel 
Published: September 2024

Abstract
Fibrolamellar carcinoma (FLC) is a liver cancer of adolescents and young adults characterized by fusions of the genes encoding the protein kinase A catalytic subunit, PRKACA, and heat shock protein, DNAJB1. The chimeric DNAJB1-PRKACA protein has increased kinase activity and is essential for FLC xenograft growth. Here, we explore the critical oncogenic pathways controlled by DNAJB1-PRKACA using patient-derived FLC models, engineered systems, and patient samples. We show that a core function of DNAJB1-PRKACA is the phosphorylation and inactivation of salt-inducible kinases (SIKs). This leads to deregulation of the CRTC2 transcriptional coactivator and p300 acetyltransferase, resulting in transcriptional reprogramming and increased global histone acetylation, driving malignant growth. Our studies establish a central oncogenic mechanism of DNAJB1-PRKACA and suggest the potential of targeting CRTC2/p300 in FLC. Notably, these findings link this rare cancer’s signature fusion oncoprotein to more common cancer gene alterations involving STK11 and GNAS, which also function via SIK suppression.

Significance:
This work combines functional studies in model systems and examination of human tumor specimens to define a central oncogenic pathway driven by DNAJB1-PRKACA fusions in FLC. DNAJB1-PRKACA-mediated inactivation of the SIK stimulates CRTC2-p300-mediated transcription to drive tumor growth. The findings illuminate pathogenic mechanisms and inform therapeutic development.
Preference and plasticity in selection of host for oviposition in Black Marsh Dart Onychargia atrocyana Selys, 1865 (Odonata: Zygoptera: Platycnemididae)
Authors: Jana Pathik K. , Mallick Priyanka Halder , Bhattacharya Tanmay 
Published: September 2024

An experimental study was conducted in a natural pond to investigate host plant preference and plasticity in damselfly Onychargia atrocyana. The hypothesis was that this species has a host preference for oviposition and also sufficient plasticity to use other hosts in the absence of the preferred host. After mating, tandems were observed landing on plants in search of suitable oviposition substrates. The majority of landings occurred on Alternanthera philoxeroides, followed by Colocasia esculenta and Commelina diffusa. The frequency of landings on A. philoxeroides and C. esculenta was not significantly different, while landings on C. esculenta and C. diffusa did differ significantly. In the absence of emergent littoral plants, the damselflies exhibited plasticity in host preference and shifted ovipositional substrate by laying eggs on submerged areas of petioles of free-floating Eichhornia crassipes. Females of O. atrocyana exhibited a flexible oviposition strategy, transitioning from a combination of emergent and submerged oviposition to primarily selecting emergent oviposition in most cases. Additionally, they divided oviposition events into multiple phases when required to ensure successful reproduction. E. crassipes supported a higher rate of oviposition compared to other plants. A multiple regression analysis demonstrated that during submerged oviposition water temperature and pH were significant predictors of the duration of submergence.
Government Fragmentation and Economic Growth
Authors: Cassidy Traviss , Velayudhan Tejaswi 
Published: September 2024

Abstract
We estimate the impact of local government fragmentation on economic activity in Indonesia over 2000–2014, when the number of districts increased by 50 percent. Exploiting idiosyncratic variation in the timing of district splits, we find that fragmentation reduces district GDP in the short termdespite large increases in central transfers. The GDP decline is larger in “child” districts that acquire a new capital and government. Furthermore, splitting districts focus spending on administration without improving public services or reducing red tape and corruption. The downsides of fragmentation due to economies of scale and low bureaucratic capacity outweigh potential upsides.
Disentangling the Effects of the 2018-2019 Tariffs on a Globally Connected U.S. Manufacturing Sector
Authors: Flaaen Aaron , Pierce Justin 
Published: September 2024

Abstract
This paper estimates the relationship between the U.S. tariff increases of 2018-2019 and outcomes in domestic manufacturing. Despite being intended to boost manufacturing activity, we find U.S. industries more exposed to tariff increases experience relative reductions in employment, as a small positive effect from import protection is offset by larger negative effects from rising input costs and retaliatory tariffs. Higher tariffs are also associated with relative increases in producer prices due to rising input costs. Lastly, we document broader labor market impacts, as counties more exposed to rising tariffs exhibit relative increases in unemployment and declines in labor force participation.
Random Subspace Local Projections
Authors: Dinh Viet Hoang , Nibbering Didier , Wong Benjamin 
Published: September 2024

Abstract
We show how random subspace methods can be adapted to estimating local projections with many controls. Random subspace methods have their roots in the machine learning literature and are implemented by averaging over regressions estimated over different combinations of subsets of these controls. We document three key results: (i) Our approach can successfully recover the impulse response functions across Monte Carlo experiments representative of different macroeconomic settings and identification schemes. (ii) Our results suggest that random subspace methods are more accurate than other dimension reduction methods if the underlying large dataset has a factor structure similar to typical macroeconomic datasets such as FRED-MD. (iii) Our approach leads to differences in the estimated impulse response functions relative to benchmark methods when applied to two widely studied empirical applications.
Social Preferences and Redistributive Politics
Authors: Fehr Ernst , Epper Thomas , Senn Julien 
Published: September 2024

Abstract
We study the link between social preferences and a behaviorally validated measure of support for redistribution. We uncover three fundamentally distinct social preference types: predominantly selfish, inequality averse and altruistic individuals. Inequality averse and altruistic individuals display a much stronger support for redistribution, particularly if they are more affluent. Beliefs about the role of effort and luck for success play no role for selfish individuals but are highly relevant for other-regarding individuals. Finally, while inequality averse individuals display strong support for policies aimed at reducing the incomes of the rich, altruistic individuals are considerably less supportive of these policies.
Gender Relations in Late Sixteenth-Century German Jest Narratives
Authors: Classen Albrecht 
Published: September 2024

Abstract
Social historians have often overlooked the evidence of popular literature as a reflection of common cultural conditions and the history of everyday life. But if we want to understand sixteenth-century society, such as in the Holy Roman Empire where the Protestant Reformation had brought about major upheavals, we would be well advised to consider the value of jest narratives that appealed to wider audiences, and this well into the seventeenth century. One of the issues in recent social-historical research has been gender relationships, whether we think of love, sexuality, marriage, or divorce. To shed light on this concern, relevant for all adults throughout early modern society, this article examines the statements about women and their relationships with their husbands in the Lalebuch (first printed in 1597) to gain a better understanding of the dominant patriarchal concepts and their challenges. Even though the anonymous author did not intend, as far as we can tell, to provide specific information about the gender relationship, in the background of the narrative we can discover numerous references of relevance for the exploration of the everyday life situation at the end of the sixteenth century concerning women’s roles within marriage and within their community.
Zu den Bezeichnungen für ‘Hügel’ im Niederländischen und Deutschen
Authors: Quak Arend 
Published: September 2024

Abstract
This article deals with the terms for ‘hill, hillock’ in Dutch and German. The common word in Modern Dutch (heuvel) has equivalents in Old Dutch and Old Saxon, especially in place names. The claim that it was imported into Dutch from eastern dialects is untenable. It is more likely that it originated in a Frankish dialect. In Modern German the term Bühel was generally used until it was replaced by the younger form Hügel, orginating in the Low or Middle German. It is furthermore suggested that the forms *huƀil-, *hugil- and *hukil- ‘hill, hillock’ are variants of one and the same word in the various dialects of Dutch and Low German.
To Sever the Limbs of US Imperialism: North Korean Support for Latin American Guerrilla Movements in the 1960s
Authors: Taylor Moe 
Published: September 2024

Abstract
During the 1960s North Korea was connected to at least nine armed leftist rebel groups in seven countries in Latin America. Pyongyang primarily supported the revolutionary aims of these groups by providing them with military training inside the dprk. This agenda stemmed from the dprk leadership’s analysis of the international situation, one heavily influenced by its experience in the Korean War and Lenin’s theory of imperialism. This analysis identified the defeat of US imperialism as the primary task of the international Left, and that this could be achieved by the proliferation of armed insurgencies throughout the global South. By contrast, the Latin American militants who travelled to the dprk to undergo intensive military training were in search of personal transformation. Inspired by the Cuban Revolution and its doctrine of foquismo, these young radicals sought a transformative experience that would facilitate their evolution from “ordinary” civilians into revolutionary guerrillas.
Socioeconomic Inequality in Accessing Professional Higher Education in India: New Evidence from a Household Survey
Authors: Choudhury Pradeep Kumar , Kumar Amit 
Published: September 2024

Using the latest National Statistical Office (NSO) education round data, we investigate the role of gender, caste and economic status of households in explaining the variations in access to professional higher education (PHE) in India. Overall, our results show significant gender and socioeconomic inequality in access to PHE courses such as engineering, management, medicine and law. For instance, we find that male students are 12.6 per cent more likely to enrol in PHE courses than their female counterparts, and this pro-male preference is more pronounced for poor households. In addition, youth belonging to scheduled caste and scheduled tribe backgrounds are less likely to access PHE than upper caste counterparts, and a considerable portion of this difference can be removed by controls for households’ economic status. These findings are significant for the recently adopted National Education Policy 2020 , which aims to make the Indian higher education system egalitarian and inclusive. JEL Codes: I21, I24
Endothelial Damage Due to Ischemia and Reperfusion is Prevented with SIN-1
Authors: Johnson D. , Freischlag J. A. , Lesniak R. , Kelly H. , Mudaliar J. H. , Cambria R. A. , Seabrook M. D. G. R. , Towne J. B. 
Published: September 2024

Background: Acute ischemia followed by reperfusion results in direct endothelial damage characterized by cell swelling, increased permeability and loss of acetylcholine-mediated vasorelaxation. Ischemia followed by reperfusion in a New Zealand white rabbit hindlimb has been shown to result in loss of acetylcholine-induced relaxation of superficial femoral arteries. This loss of relaxation in response to acetylcholine is a reflection of the decreased nitric oxide availability that occurs with reperfusion injury. The purpose of this investigation was to evaluate the effect of SIN-1. a direct nitric oxide donor, on this endothelial injury. Methods: New Zealand white rabbits underwent complete ischemia of the right hindlimb for 3 h followed by 2 h of reperfusion. Aliquots of 20 ml of either 0.88-mM S1N-1 or normal saline was infused via a lateral branch of the right common iliac artery during the first 20 min of reperfusion. Sham vessels were subjected to the 5-h operative intervention to control for anesthetic effect. Control vessels were harvested from rabbits not exposed to ischemia or reperfusion. Superficial femoral artery rings were evaluated in vitro for endothelial cell-mediated relaxation. Rings were contracted with potassium chloride and norepinephrine and then exposed to standardized incremental doses of acetylcholine to measure percent relaxation. Artery sections were sent for hematoxylin and eosin staining. Results: No significant differences were seen in contraction caused by either potassium chloride or norepinephrine in ail four experimental groups. Saline infused vessel rings relaxed a mean of 8.42 ± 2.39% and 49.57 ± 8.65% in response to acetylcholine doses of 3 × 10−8 M and 1 × 10−7M, respectively. In contrast, SIN-1 infused vessels relaxed a mean of 57.82 ± 2.65% and 100.23 ± 1.53% to the same doses of acetylcholine. Control and sham arteries showed a similar relaxation response as compared with SIN-1 infused vessels. Differences in relaxation when comparing saline infused vessels with SIN-1 infused, sham and control arteries, were significantly different at each dose of acetylcholine from 3 × 10−8M to 1 × 10−7M ( P < 0.05, ANOVA). Histologic examination of the vessels revealed no morphologic differences among the experimental groups. All vessels were structurally normal with an intact endothelium. Conclusion: In this model of rabbit hindlimb ischemia, preservation of endothelial cell-mediated vasorelaxation occurs with administration of intra-arterial SIN-1 during reperfusion. This preservation of endothelial function cannot be explained by histologic changes in the arterial wall or attributed to altered arterial contractility in response to potassium chloride or norepinephrine.
Outcomes and patient satisfaction after Penuma silicone implant surgery via two surgical approaches
Authors: Salkowski Morgan , Levine Laurence A. 
Published: September 2024

Background: The Penuma is a soft silicone penile implant designed for cosmetic enhancement of the flaccid penis in men who have normal erections. Objectives: The goal of this study is to report outcomes on patient satisfaction at least 6 months after Penuma subcutaneous penile implant for cosmetic enhancement of the penis, and to determine if modifications in surgical approach resulted in reduction in postoperative complications. Design: Penile measurements, adverse events, and patient satisfaction were compared between patients undergoing the new lateral scrotal incision versus the traditional infrapubic approach. Methods: A retrospective chart review was performed on all patients who underwent a Penuma implant by a single surgeon from April 2019 to December 2022. A 26-item non-validated device-specific questionnaire was sent to patients at least 6 months after the date of their initial surgery. Results: A total of 92 cases were performed by a single surgeon. The average increase in flaccid length was 2.5 cm (±2.2), representing a 44% increase ( p < 0.01). The average increase in girth was 3.1 cm (±1.8 cm), a 32% change ( p < 0.01). Seroma requiring drainage occurred in 12%. 7% of patients required operative revision of the implant. When assessed by surgical approach, the revision rate was significantly higher in infrapubic patients (13% vs 2%, p < 0.05). The implant removal rate was also significantly higher when the infrapubic approach was used (21% vs 6%, p < 0.05). 82% of patients reported being satisfied or very satisfied with their postoperative penile appearance. 75% of patients would undergo surgery again. Conclusion: The subcutaneous Penuma penile implant appears to improve satisfaction with regard to the appearance of the penis and is a viable option for men who desire to enhance flaccid penile length and girth. Furthermore, the lateral scrotal surgical approach appears to have a lower postoperative complication rate.
Determinants of STI Risk Behaviors as a Function of Alcohol use and Incarceration History Among Male Adolescent Offenders
Authors: Stephens Torrance 
Published: September 2024

Aims: The purpose of this analysis was to identify bivariate correlates of history of prior incarceration, and self-reported risky sexual practices among a sample of adolescent male detainees. Methods: The current analyses included 139 male adolescent offenders enrolled in an AOD/HIV prevention intervention conducted in a juvenile detention facility in a major Southeastern city in the USA. Significance tests were conducted using univariate logistic regressions to examine the independent associations of prior arrest history, and self-reported risky behaviors prior to this recent incarceration. Results: Adolescents who identified as having a prior arrest history were more likely to report they had willingly had sex with a prostitute (OR = 2.78, 95% CI = 1.29–5.95), used alcohol or other drugs to get a desired effect (OR = 3.39, 95% CI = 1.18–9.68), had tattoos (OR = 4.18, 95% CI = 1.78–9.78) and were addicted to AODs (OR = 2.51, 95% CI = 0.77–8.16). Conclusion: Findings suggest that risk practices that increase risk for STIs among adolescent male offenders, maybe a function of incarceration history.
Open Pectoralis Major Repair: Endobutton Fixation
Authors: Tadepalli Vaibhav R. , Schwartz Joshua M. , Tagliero Adam J. , Goodloe J. Brett , Gwathmey F. Winston , Brockmeier Stephen F. , Werner Brian C. 
Published: September 2024

Background: Rupture of the pectoralis major is most commonly seen with eccentric contraction mechanisms, and surgical options in the setting of acute tear include direct repair, endocortical buttons, suture anchors, and transosseous tunnel fixation. This technique video will detail repair using a unicortical endobutton fixation construct. Indications: Surgical repair is indicated for acute, complete pectoralis major tears; incomplete tears involving rupture of the sternal head with intact clavicular head; and tears in the young, active, high-demand demographic. Delay in diagnosis increases the risk of tendon retraction and fatty atrophy. Recent literature has shown that acute repair is superior to chronic repair in functional outcome, pain relief, and overall cosmesis. Technique Description: A beach-chair position and a deltopectoral approach are used to identify and mobilize the torn and retracted sternal head of the pectoralis major. A No. 2 SutureTape is then passed through the disrupted sternal head in a Krackow fashion to allow for a 6-strand repair. Two of the suture strands are then shuttled through the endocortical button. A drill is used to create a corticectomy for endobutton placement, which is secured into place by sequentially tightening each limb. Two additional endobuttons are placed in a similar fashion to complete the construct. Results: Outcomes studies regarding patients with pectoralis major tendon ruptures who underwent endocortical button fixation reveal that 83% of patients had good or excellent outcomes in a recent systematic review. Another study showed no significant difference in functional outcomes, return to activity, or complication rate with endocortical button fixation compared with other mechanisms of fixation. Discussion/Conclusion: Unicortical endobutton fixation can provide another fixation strategy for acute pectoralis major tears in young, active high-demand individuals. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
EASIX and m-EASIX predict CRS and ICANS in pediatric and AYA patients after CD19-CAR T-cell therapy
Authors: Zandaki Dua’a , Selukar Subodh , Bi Yu , Li Ying , Zinsky Megan , Bonifant Challice L. , Epperly Rebecca , Keerthi Dinesh , Triplett Brandon M. , Gottschalk Stephen , Naik Swati , Talleur Aimee C. 
Published: September 2024

Abstract
Cytokine release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS) are complications of CD19-directed chimeric antigen receptor (CD19-CAR) T-cell therapy. The Endothelial Activation and Stress Index (EASIX) and modified EASIX (m-EASIX) scores have been retrospectively proven to be predictive of CRS and ICANS in adult CAR T-cell recipients. However, these scores have not been evaluated in pediatric cohorts. We retrospectively report on 76 pediatric and adolescent and young adult (AYA) patients with relapsed/refractory B-cell acute lymphoblastic leukemia treated with CD19-CAR T cells at St. Jude Children’s Research Hospital or Johns Hopkins Hospital. Data included patient, disease, and treatment characteristics. EASIX and m-EASIX scores were calculated at days –5 before, 0, and +3 after CAR T-cell infusion. CRS and ICANS occurred in 47 and 17 patients, respectively. At all evaluated time points, the median EASIX scores were higher for patients who developed severe CRS and any grade ICANS, and the median m-EASIX scores were higher in patients who developed severe CRS and severe ICANS than those with no/mild CRS/ICANS. Receiver operating characteristic curve analysis showed that both scores were strong predictors of CRS, especially severe CRS, at all time points. Any grade and severe ICANS were best predicted by both scores at day +3. m-EASIX uniformly outperformed EASIX, except for predicting any grade ICANS. Our results validate the potential utility of EASIX and m-EASIX scores for predicting CAR T-cell–related complications for pediatric and AYA patients.