bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Alumina‐Supported Copper Iodide: An Efficient and Recyclable Catalyst for Microwave‐Assisted Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles via Three‐Component Reaction in Water.
Authors: Agalave Sandip G. , Pharande Shrikant G. , Gade Swapna M. , Pore Vandana S. 
Published: December 2015

AbstractThe reaction proceeds well with benzyl halides and arylalkynes while halobenzenes fail and alkylalkynes (e.g., 1‐hexyne and cyclohexylalkyne) give complex mixtures.
ChemInform Abstract: Palladium‐Catalyzed Arylation of 2H‐Chromene: A New Entry to Pyrano[2,3‐c]carbazoles.
Authors: Ranjith Reddy K. , Siva Reddy A. , Dhaked Devendra K. , Rasheed S. K. , Pathania Anup Singh , Shankar Ravi , Malik Fayaz , Das Parthasarathi 
Published: December 2015

AbstractSuzuki—Miyaura cross‐coupling of (het)arylboronic acids with chromene derivative (I) provides the corresponding 5‐(het)arylated chromenes that can be subjected to Cadogan reaction to give the title compounds.
ChemInform Abstract: Asymmetric Addition of Pyridyl Aluminum Reagents to Aldehydes Catalyzed by a Titanium(IV) Catalytic System of (R)‐H8‐BINOLate.
Authors: Zhang Lijun , Tu Bing , Ge Min , Li Yimei , Chen Liangyu , Wang Wei , Zhou Shuangliu 
Published: December 2015

AbstractA series of optically active pyridyl methanols is available with the title reaction.
ChemInform Abstract: Poly(N‐bromo‐N‐ethyl‐benzene‐1,3‐disulfonamide) [PBBS] and N,N,N′,N′‐Tetrabromobenzene‐1,3‐disulfonamide [TBBDA] as New Efficient Reagents for One‐Pot Synthesis of Furano and Pyrano Pyrimidinones (Thiones).
Authors: Ghorbani‐Vaghei Ramin , Maghbooli Yaser , Mahmoodi Jafar , Shahriari Azadeh 
Published: December 2015

AbstractTBBDA gives slightly better yields than the corresponding PBBS reagent.
ChemInform Abstract: Subergane‐Type Sesquiterpenes from Gorgonian Coral Subergorgia suberosa with Antibacterial Activities.
Authors: Huang Qixi , Cheng Wei , Long Hailin , Liu Huagang , van Ofwegen Leen , Lin Wenhan 
Published: December 2015

AbstractEpoxysubergorgic acid (I) is isolated from the gorgonian coral Subergorgia suberosa along with seven known sesquiterpenes.
ChemInform Abstract: A New Cyclopropyl‐Triterpenoid from Ochradenus arabicus.
Authors: Ali Liaqat , Ahmad Riaz , Ur Rehman Najeeb , Latif Khan Abdul , Hassan Zahid , Shamim Rizvi Tania , Al‐Harrasi Ahmed , Khan Shinwari Zabta , Hussain Javid 
Published: December 2015

AbstractThe new cyclopropyl‐triterpenoid is isolated along with four known compounds from the aerial parts of Ochradenus arabicus.
ChemInform Abstract: Palladium‐Catalyzed Formal Insertion of Carbenoids into Aminals via C—N Bond Activation.
Authors: Qin Guiping , Li Lixin , Li Jiawen , Huang Hanmin 
Published: December 2015

AbstractThis method gives α,β‐diamino acid esters with tertiary and quaternary α‐carbon‐centers in good yields and under mild conditions.
ChemInform Abstract: A New Fusarielin Analogue(I) from Penicillium sp. Isolated from the Mediterranean Sponge Ircinia oros.
Authors: Chen Huiqin , Aktas Nihal , Konuklugil Belma , Mandi Attila , Daletos Georgios , Lin Wenhan , Dai Haofu , Kurtan Tibor , Proksch Peter 
Published: December 2015

Abstractisolation, structure elucidation, and cellular cytotoxicity
ChemInform Abstract: Stereochemistry of Phenylpiracetam and Its Methyl Derivative: Improvement of the Pharmacological Profile
Authors: Veinberg Grigory , Vavers Edijs , Orlova Natalja , Kuznecovs Jevgenijs , Domracheva Ilona , Vorona Maxim , Zvejniece Liga , Dambrova Maija 
Published: December 2015

AbstractReview: 29 refs.
Spiegelbildliche Nukleinsäuren als pharmakologische Wirkstoffe
Authors: Hoehlig Kai , Klussmann Sven 
Published: December 2015

AbstractIn den vergangenen Jahrzehnten wurde eine Reihe von Methoden entwickelt, die den Einsatz von Nukleinsäuren für therapeutische Zwecke ermöglichen. Mit Hilfe spezieller kurzer RNA‐ und DNA‐Moleküle kann die Expression einzelner Gene gezielt unterdrückt werden (gene silencing). Aptamere bieten eine Alternative zu monoklonalen Antikörpern. Eine Voraussetzung für die pharmakologische Verwendung von Nukleinsäuren ist eine hohe Stabilität gegenüber abbauenden körpereigenen Enzymen. Dies kann durch den Einsatz nicht‐natürlicher spiegelbildlicher Nukleinsäuren erreicht werden. Der Artikel beschreibt die Prinzipien der Stereochemie, die diesem Ansatz zugrunde liegen und zeigt, wie diese für die Identifizierung spiegelbildlicher Aptamere genutzt werden. Gleichzeitigt wird erläutert, warum die Stereospezifität der Watson‐Crick‐Basenpaarungen den Einsatz spiegelbildlicher Nukleinsäuren beim gene silencing verhindert und welche neuen Ansätze dies in Zukunft überwinden könnten.
Nobelpreis für Chemie 2015
Authors: Kaina Bernd 
Published: December 2015

AbstractEr war überfällig. Und es war sicherlich keine einfache Entscheidung für das Nobel‐Komitee, die Kandidaten herauszufiltern, deren Arbeiten auf dem großen Gebiet der DNA‐Reparatur eine Schlüsselstellung einnehmen.
Young investigator challenge: Cytomorphologic analysis of cerebrospinal fluid in 70 pediatric patients with medulloblastoma and review of the literature focusing on novel diagnostic and prognostic tests
Authors: Damiani Domenico , Suciu Voichita , Andreiuolo Felipe , Calderaro Julien , Vielh Philippe 
Published: December 2015

BACKGROUNDMedulloblastoma (MB) is the most common malignant pediatric brain tumor and is currently treated with combined therapies. Recent advances in genetics and protein expression in this entity have led to the elaboration of a new molecular classification, and novel targeted therapies are currently under trial. This objective of this study was to describe the cytomorphologic features of MB in cerebrospinal fluid (CSF).METHODSThe authors conducted a retrospective study of 194 CSF samples from 70 pediatric patients who had a history of primary MB. The samples consisted of CSF cytospins that were stained according to the May‐Grunwald Giemsa and/or Papanicolaou methods.RESULTSIn 32 patients, it was possible to establish a confident diagnosis of metastatic MB. Common morphologic features included cell clustering, nuclear irregularity, molding and enlargement, and prominent nucleoli. Multinucleation as well as mitotic and apoptotic figures were less frequently observed. Fifteen samples that presented neither cell clustering nor nuclear molding were classified as suspicious.CONCLUSIONSCell clustering with nuclear molding is a key feature for the diagnosis of leptomeningeal metastasis of MB. Cancer (Cancer Cytopathol) 2015;123:644–649. © 2015 American Cancer Society.
Space‐discretization error analysis and stabilization schemes for conduction velocity in cardiac electrophysiology
Authors: Pezzuto S. , Hake J. , Sundnes J. 
Published: December 2015

SummaryIn cardiac electrophysiology, the propagation of the action potential may be described by a set of reaction–diffusion equations known as the bidomain model. The shape of the solution is determined by a balance of a strong reaction and a relatively weak diffusion, which leads to steep variations in space and time. From a numerical point of view, the sharp spatial gradients may be seen as particularly problematic, because computational grid resolution on the order of 0.1 mm or less is required, yielding considerable computational efforts on human geometries. In this paper, we discuss a number of well‐known numerical schemes for the bidomain equation and show how the quality of the solution is affected by the spatial discretization. In particular, we study in detail the effect of discretization on the conduction velocity (CV), which is an important quantity from a physiological point of view. We show that commonly applied finite element techniques tend to overestimate the CV on coarse grids, while it tends to be underestimated by finite difference schemes. Furthermore, the choice of interpolation and discretization scheme for the nonlinear reaction term has a strong impact on the CV. Finally, we exploit the results of the error analysis to propose improved numerical methods, including a stabilized scheme that tends to correct the CV on coarse grids but converges to the correct solution as the grid is refined. Copyright © 2016 John Wiley & Sons, Ltd.
Intercontinental correlation of organic carbon and carbonate stable isotope records: evidence of climate and sea‐level change during the Turonian (Cretaceous)
Authors: Jarvis Ian , Trabucho‐Alexandre João , Gröcke Darren R. , Uličný David , Laurin Jiří 
Published: December 2015

AbstractCarbon (δ13Corg, δ13Ccarb) and oxygen (δ18Ocarb) isotope records are presented for an expanded Upper Cretaceous (Turonian–Coniacian) hemipelagic succession cored in the central Bohemian Cretaceous Basin, Czech Republic. Geophysical logs, biostratigraphy and stable carbon isotope chemostratigraphy provide a high‐resolution stratigraphic framework. The δ13Ccarb and δ13Corg profiles are compared, and the time series correlated with published coeval marine and non‐marine isotope records from Europe, North America and Japan. All previously named Turonian carbon isotope events are identified and correlated at high‐resolution between multiple sections, in different facies, basins and continents. The viability of using both carbonate and organic matter carbon isotope chemostratigraphy for improved stratigraphic resolution, for placing stage boundaries, and for intercontinental correlation is demonstrated, but anchoring the time series using biostratigraphic data is essential. An Early to Middle Turonian thermal maximum followed by a synchronous episode of stepped cooling throughout Europe during the Middle to Late Turonian is evidenced by bulk carbonate and brachiopod shell δ18Ocarb data, and regional changes in the distribution and composition of macrofaunal assemblages. The Late Turonian Cool Phase in Europe was coincident with a period of long‐term sea‐level fall, with significant water‐mass reorganization occurring during the mid‐Late Turonian maximum lowstand. Falling Δ13C (δ13Ccarb – δ13Corg) trends coincident with two major cooling pulses, point to pCO2 drawdown accompanying cooling, but the use of paired carbon isotopes as a high‐resolution pCO2 proxy is compromised in the low‐carbonate sediments of the Bohemian Basin study section by diagenetic overprinting of the δ13Ccarb record. Carbon isotope chemostratigraphy is confirmed as a powerful tool for testing and refining intercontinental and marine to terrestrial correlations.
Effects of early adolescent environmental enrichment on cognitive dysfunction, prefrontal cortex development, and inflammatory cytokines after early life stress
Authors: do Prado Carine H. , Narahari Tanya , Holland Freedom H. , Lee Ha‐Neul , Murthy Shashi K. , Brenhouse Heather C. 
Published: December 2015

ABSTRACTEarly postnatal stress such as maternal separation causes cognitive dysfunction later in life, including working memory deficits that are largely mediated by the prefrontal cortex. Maternal separation in male rats also yields a loss of parvalbumin‐containing prefrontal cortex interneurons in adolescence, which may occur via inflammatory or oxidative stress mechanisms. Environmental enrichment can prevent several effects of maternal separation; however, effects of enrichment on prefrontal cortex development are not well understood. Here, we report that enrichment prevented cognitive dysfunction in maternally separated males and females, and prevented elevated circulating pro‐inflammatory cytokines that was evident in maternally separated males, but not females. However, enrichment did not prevent parvalbumin loss or adolescent measures of oxidative stress. Significant correlations indicated that adolescents with higher oxidative damage and less prefrontal cortex parvalbumin in adolescence committed more errors on the win‐shift task; therefore, maternal separation may affect cognitive dysfunction via aberrant interneuron development. © 2015 Wiley Periodicals, Inc. Dev Psychobiol 58: 482–491, 2016.
Photocurrent Response of Two ­Metal(II) Complexes Based on Rigid Ligands
Authors: Zhang Pan , Gong Yun , Lin Jian‐Hua 
Published: December 2015

AbstractTwo metal(II) complexes formulated as Cd3L(L1)3(H2O) (1) and Zn3L(BTC)2(H2O)·7H2O (2) {L = 4‐[4‐(1H‐imidazol‐1‐yl)phenyl]‐2,6‐di(pyridin‐4‐yl)pyridine, H2L1 = 2,5‐bis(3′‐carboxylphenyl)pyridine, H3BTC = 1,3,5‐benzenetricarboxylic acid} were synthesized and structurally characterized by single‐crystal X‐ray diffraction. Complex 1 displays a two‐nodal (3,7)‐connected 3D architecture with a novel (4.62)(48.610.83) topology, in which a Cd3 unit with a Cd···Cd separation of 3.5 Å is observed. Complex 2 possesses two kinds of Zn2 units, and it shows a (3,4,7)‐connected 3D architecture with a novel (4.62)6(43.66.811.10)2(64.82) topology. Complexes 1 and 2 both exhibit quasireversible redox properties, and a photocurrent could be produced on the two complexes upon visible‐light illumination (650 nm > λ > 350 nm). However, different photocurrent responses were observed on the two complexes, and complex 1 yielded a photocurrent density that was higher than that of the bare Si wafer and complex 2, probably because of different charge‐transfer impedances at the interfaces and charge‐carrier concentrations in the photoelectrodes.
The Synthesis of Quinolone Natural Products from Pseudonocardia sp.
Authors: Salvaggio Flavia , Hodgkinson James T. , Carro Laura , Geddis Stephen M. , Galloway Warren R. J. D. , Welch Martin , Spring David R. 
Published: December 2015

AbstractThe synthesis of four quinolone natural products from the actinomycete Pseudonocardia sp. is reported. The key step involved a sp2–sp3 Suzuki–Miyaura reaction between a common boronic ester lateral chain and various functionalised quinolone cores. The quinolones slowed growth of E. coli and S. aureus by inducing extended lag phases.
Sciatic endometriosis induces mechanical hypersensitivity, segmental nerve damage, and robust local inflammation in rats
Authors: Chen S. , Xie W. , Strong J.A. , Jiang J. , Zhang J.‐M. 
Published: December 2015

AbstractBackgroundEndometriosis is a common cause of pain including radicular pain. Ectopic endometrial tissue may directly affect peripheral nerves including the sciatic, which has not been modelled in animals.MethodsWe developed a rat model for sciatic endometriosis by grafting a piece of autologous uterine tissue around the sciatic nerve. Control animals underwent a similar surgery but received a graft of pelvic fat tissue.ResultsThe uterine grafts survived and developed fluid‐filled cysts; the adjacent nerve showed signs of swelling and damage. Mechanical and cold hypersensitivity and allodynia of the ipsilateral hindpaw developed gradually over the first 2 weeks after the surgery, peaked at 2–5 weeks, and was almost resolved by 7 weeks. Control animals showed only minor changes in these pain behaviours. Histological signs of inflammation in the uterine graft and in the adjacent nerve were observed at 3 weeks but were resolving by 7 weeks. In vivo fibre recording showed increased spontaneous activity, especially of C‐fibres, in sciatic nerve proximal to the uterine graft. Several pro‐inflammatory cytokines including interluekin‐18, VEGF, fractalkine, and MIP‐1α, were elevated in the uterine graft plus sciatic nerve samples, compared to samples from normal nerve or nerve plus fat graft. Growth associated protein 43 (GAP43), a marker of regenerating nerve fibres, was observed in the adjacent sciatic nerve as well as in the uterine graft.ConclusionsThis model shared many features with other rat models of endometriosis, but also had some unique features more closely related to neuropathic pain models.What does this study/review addSome especially painful forms of endometriosis are essentially neuropathic, because peripheral nerves are directly affected by nearby ectopic endometrial tissue. We modelled endometriosis by implanting autologous uterine tissue around rat sciatic nerve. We observed mechanical and cold pain behaviours along with signs of inflammation and nerve damage and increased pro‐inflammatory cytokines at the implant site. Pain behaviours correlated with signs of nerve inflammation and damage rather than with cyst survival.
Development and assessment of damage‐to‐loss models for moment‐frame reinforced concrete buildings
Authors: Martins Luís , Silva Vítor , Marques Mário , Crowley Helen , Delgado Raimundo 
Published: December 2015

SummaryThe assessment of earthquake loss often requires the definition of a relation between a measure of damage and a quantity of loss, usually achieved through the employment of a damage‐to‐loss model. These models are frequently characterized by a large variability, which inevitably increases the uncertainty in the vulnerability assessment and earthquake loss estimation. This study provides an insight on the development of damage‐to‐loss functions for moment‐frame reinforced concrete buildings through an analytical methodology. Tri‐dimensional finite element models of existing reinforced concrete buildings were subjected to a number of ground motion records compatible with the seismicity in the region of interest, through nonlinear dynamic analysis. These results were used to assess, for a number of damage states, the probability distribution of loss ratio, taking into consideration member damage and different repair techniques, as well as to derive sets of fragility functions. Then, a vulnerability model (in terms of the ratio of cost of repair to cost of replacement, conditional on the level of ground shaking intensity) was derived and compared with the vulnerability functions obtained through the combination of various damage‐to‐loss models with the set of fragility functions developed herein. In order to provide realistic estimates of economic losses due to seismic action, a comprehensive study on repair costs using current Portuguese market values was also carried out. The results of this study highlight important issues in the derivation of vulnerability functions, which are a fundamental component for an adequate seismic risk assessment. © 2015 The Authors. Earthquake Engineering & Structural Dynamics published by John Wiley & Sons Ltd.
Study of phase behavior and physical properties of a natural gas reservoir with high carbon dioxide content
Authors: Chen Hao , Yang Shenglai , Zhang Xiansong , Ren Shuangshuang , Dong Kai , Li Ying , Meng Zhan , Wang Lu , Lei Hao , Ma Quanzheng 
Published: December 2015

AbstractThe discovery of natural gas reservoirs with high and varying CO2 content (5% to 98%) in China has attracted worldwide attention. In this paper, the phase diagram of natural gas with different CO2 content was calculated and drawn by PVT Sim 100 which was fitted by experimental data based on the Ruska PVT 2730 apparatus. Both the real critical parameters and the pseudo‐critical para­meters were calculated and compared. Also, the phase state of natural gas along the wellbore in a representative well under both shut‐in and flowing conditions was analyzed. In addition, to clarifying the phase transition process, videos of a gas sample showed variation between supercritical state to gas‐liquid state with isobaric cooling and heating up between 35°C and 25°C. Moreover, the compressibility factor (Z‐factor) of the natural gas with different CO2 content was chosen as one of the key physical parameters of natural gas to measure at pressures ranging from atmospheric pressure to 45 MPa and temperatures ranging from 40°C to 140°C experimentally. Results show that the Z factor decreases with the increase of CO2 content in natural gas at isothermal conditions, and increases with the increase of temperature. Furthermore, a new model is proposed to predict pressure and Z factor. The varying CO2‐CH4 concentrations of this reservoir are relevant to gas compositions which may arise in depleted natural gas reservoirs used for geologic carbon sequestration. © 2015 Society of Chemical Industry and John Wiley & Sons, Ltd
Lifespan anxiety is reflected in human amygdala cortical connectivity
Authors: He Ye , Xu Ting , Zhang Wei , Zuo Xi‐Nian 
Published: December 2015

AbstractThe amygdala plays a pivotal role in processing anxiety and connects to large‐scale brain networks. However, intrinsic functional connectivity (iFC) between amygdala and these networks has rarely been examined in relation to anxiety, especially across the lifespan. We employed resting‐state functional MRI data from 280 healthy adults (18–83.5 yrs) to elucidate the relationship between anxiety and amygdala iFC with common cortical networks including the visual network, somatomotor network, dorsal attention network, ventral attention network, limbic network, frontoparietal network, and default network. Global and network‐specific iFC were separately computed as mean iFC of amygdala with the entire cerebral cortex and each cortical network. We detected negative correlation between global positive amygdala iFC and trait anxiety. Network‐specific associations between amygdala iFC and anxiety were also detectable. Specifically, the higher iFC strength between the left amygdala and the limbic network predicted lower state anxiety. For the trait anxiety, left amygdala anxiety–connectivity correlation was observed in both somatomotor and dorsal attention networks, whereas the right amygdala anxiety–connectivity correlation was primarily distributed in the frontoparietal and ventral attention networks. Ventral attention network exhibited significant anxiety–gender interactions on its iFC with amygdala. Together with findings from additional vertex‐wise analysis, these data clearly indicated that both low‐level sensory networks and high‐level associative networks could contribute to detectable predictions of anxiety behaviors by their iFC profiles with the amygdala. This set of systems neuroscience findings could lead to novel functional network models on neural correlates of human anxiety and provide targets for novel treatment strategies on anxiety disorders. Hum Brain Mapp 37:1178–1193, 2016. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
Greater loss of object than spatial mnemonic discrimination in aged adults
Authors: Reagh Zachariah M. , Ho Huy D. , Leal Stephanie L. , Noche Jessica A. , Chun Amanda , Murray Elizabeth A. , Yassa Michael A. 
Published: December 2015

ABSTRACTPrevious studies across species have established that the aging process adversely affects certain memory‐related brain regions earlier than others. Behavioral tasks targeted at the function of vulnerable regions can provide noninvasive methods for assessing the integrity of particular components of memory throughout the lifespan. The present study modified a previous task designed to separately but concurrently test detailed memory for object identity and spatial location. Memory for objects or items is thought to rely on perirhinal and lateral entorhinal cortices, among the first targets of Alzheimer's related neurodegeneration. In line with prior work, we split an aged adult sample into “impaired” and “unimpaired” groups on the basis of a standardized word‐learning task. The “impaired” group showed widespread difficulty with memory discrimination, whereas the “unimpaired” group showed difficulty with object, but not spatial memory discrimination. These findings support the hypothesized greater age‐related impacts on memory for objects or items in older adults, perhaps even with healthy aging. © 2015 Wiley Periodicals, Inc.