bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methotrexate encephalopathy: Two cases in adult cancer patients, who recovered with pathophysiologically based therapy
Authors: Coker Shodeinde A , Pastel David A , Davis Melissa C , Bengtson Elizabeth M , Fadul Camilo E , Lewis Lionel D 
Published: May 2017

Background/Objectives: Neurotoxicity is a serious and sometimes fatal adverse effect that can occur following methotrexate treatment. We describe two adult patients with hematological malignancies with methotrexate encephalopathy who recovered with dextromethorphan therapy. Results: Case 1: A 24-year-old male with acute lymphoblastic leukemia developed the acute onset of bilateral facial weakness and slurred speech after his first treatment with high-dose intravenous methotrexate. The clinical scenario and a head magnetic resonance imaging supported a diagnosis of methotrexate encephalopathy. Treatment with dextromethorphan was coincident with recovery. Case 2: A 65-year-old female with recurrent diffuse large B-cell lymphoma was treated with high-dose intravenous methotrexate. Two weeks after a cycle, she developed hypoactive delirium, marked lethargy, ocular ataxia, and a right-sided facial weakness. Within 2 days of starting dextromethorphan, there was improvement with clinical recovery. Conclusions: These two cases suggest that N-methyl d-aspartate receptor activation by homocysteine may play an important role in the pathogenesis of methotrexate neurotoxicity.
Caecocolic intussusception associated with a caecal polyp and concurrent hepatocellular carcinoma in a cat
Authors: Boland Lara , Lindsay Scott , Brunel Laurencie , Podadera Juan , Bennett Peter 
Published: May 2017

Case summary A 17-year-old female neutered domestic shorthair cat presented for several days of reduced faecal volume and a rectal prolapse. Physical examination revealed a 2 cm rectal prolapse, hepatomegaly and a low body condition score of 3/9. Haematology and biochemistry revealed a mild non-regenerative anaemia (haematocrit 24.5%; reference interval [RI] 30.3–52.3%), a mild mature neutrophilia (16.21 × 109/l; RI 1.48–10.29 × 109/l) and a mild increase in alanine aminotransferase activity (222 IU/l; RI 12–130 IU/l). Abdominal radiographs identified hepatomegaly. The rectal prolapse was reduced under general anaesthesia. Abdominal ultrasound identified a caecocolic intussusception and a large hepatic mass. Thoracic radiographs were unremarkable. Hepatic fine-needle aspirate cytology revealed well-differentiated hepatocytes. A typhlectomy was performed and the quadrate liver lobe, with mass, was resected. Gross examination of the caecum identified a focal polyp; histopathology showed moderate plasmacytic–lymphocytic typhlitis and reactive mucosal-associated lymphoid tissue. The hepatic mass was diagnosed as a well-differentiated hepatocellular carcinoma. Six weeks postoperatively the cat had gained 0.5 kg, had an improved body condition score of 5/9 and resolution of clinical signs. The cat died acutely 1 year later from an unknown cause. Relevance and novel information Caecocolic intussusception is rare in cats and uncommon in dogs. This is the third report in a cat and the first associated with a caecal polyp. As reported in dogs, the outcome following surgery was good. Hepatocellular carcinoma is a rarely reported feline neoplasm, which may have a good prognosis with surgical resection.
ETS‐targeted therapy: can it substitute for MEK inhibitors?
Authors: Tetsu Osamu , McCormick Frank 
Published: May 2017

AbstractBackgroundThe RAS/MAPK pathway has been intensively studied in cancer. Constitutive activation of ERK1 and ERK2 is frequently found in cancer cells from a variety of tissues. In clinical practice and clinical trials, small molecules targeting receptor tyrosine kinases or components in the MAPK cascade are used for treatment. MEK1 and MEK2 are ideal targets because these enzymes are physiologically important and have narrow substrate specificities and distinctive structural characteristics. Despite success in pre‐clinical testing, only two MEK inhibitors, trametinib and cobimetinib, have been approved, both for treatment of BRAF‐mutant melanoma. Surprisingly, the efficacy of MEK inhibitors in other tumors has been disappointing. These facts suggest the need for a different approach. We here consider transcription factor ETS1 and ETS2 as alternate therapeutic targets because they are major MAPK downstream effectors.Main textThe lack of clinical efficacy of MEK inhibitors is attributed mostly to a subsequent loss of negative feedback regulation in the MAPK pathway. To overcome this obstacle, second‐generation MEK inhibitors, so‐called “feedback busters,” have been developed. However, their efficacy is still unsatisfactory in the majority of cancers. To substitute ETS‐targeted therapy, therapeutic strategies to modulate the transcription factor in cancer must be considered. Chemical targeting of ETS1 for proteolysis is a promising strategy; Src and USP9X inhibitors might achieve this by accelerating ETS1 protein turnover. Targeting the ETS1 interface might have great therapeutic value because ETS1 dimerizes itself or with other transcription factors to regulate target genes. In addition, transcriptional cofactors, including CBP/p300 and BRD4, represent intriguing targets for both ETS1 and ETS2.ConclusionsETS‐targeted therapy appears to be promising. However, it may have a potential problem. It might inhibit autoregulatory negative feedback loops in the MAPK pathway, with consequent resistance to cell death by ERK1 and ERK2 activation. Further research is warranted to explore clinically applicable ways to inhibit ETS1 and ETS2.
A contemporary, empowered female figure? Towards a feminist reading of Frimpong-Manso’s Life and Living It and The Perfect Picture
Authors: Kwansah-Aidoo Kwamena , Owusu Joyce Osei 
Published: May 2017

Abstract
This article examines the contemporary Ghanaian female figure as portrayed in two video films by Shirley Frimpong-Manso: Life and Living It (2007) and The Perfect Picture (2009). Though the selected films individually foreground male and female subjectivities, they share similar recurring motifs in female characterization. Using the postfeminist and African feminist frameworks as conceptual lenses, we interrogate the precise ways in which the female characters are portrayed and note that the films emphasize women’s freedom and choice – individualism and self-determination; challenge male dominance; encourage female sexual empowerment; and female friendship and bonding. We conclude that, in spite of a few instances where the two films appear to uphold normative notions of femininity, they overwhelmingly portray contemporary empowered female characters, framed within African feminist and postfeminist perspectives and cultures. Ultimately, the paper seeks to show the extent to which a feminist framework can initiate new thinking and affect wider social perceptions.
Monetary policy and energy price shocks
Authors: Huynh Bao Tan 
Published: May 2017

AbstractA New Keynesian framework with endogenous energy production is proposed to investigate the role of monetary policy in addressing disturbances in energy markets. The novelty of the model lies in the endogenous production of energy with convex costs, explicit modeling of goods with different degrees of energy-dependency and sectoral price rigidities. Our analyses prescribe the desirable monetary responses to four types of energy price shocks, highlighting the distinct characteristics of each shock and affirming the need for diverse policy considerations. We also found several points of divergence in relation to previous studies on addressing energy supply shocks. In addition, we shed light on the role of sectoral price rigidities in the shocks’ propagation.
Comparative Evaluation of Spark Plasma and Conventional Sintering of NiO/YSZ Layers for Metal-Supported Solid Oxide Fuel Cells
Authors: Ivashutenko A. S. , Ionov I. V. , Maznoy A. S. , Sivkov A. A. , Solovyev A. A. 
Published: May 2017

AbstractNiO/YSZ anode layers for metal-supported solid oxide fuel cells (MS-SOFCs) were fabricated by spark plasma sintering (SPS). SPS parameters were optimized in order to achive anodes of the desired microstructure. The effect of sintering conditions on microstructure of NiO/YSZ was studied by scanning electron microscopy and X-ray diffractometry. Also NiO/YSZ layers were formed on porous metal supports by a screen-printing method and sintered in inert atmosphere and vacuum by conventional sintering technique. At temperatures above 1,200 °С in inert atmosphere and vacuum nickel oxide dissociation and its massive agglomeration are observed during conventional sintering. SPS process allows sintering of NiO/YSZ granules without NiO dissociation, Ni agglomeration and the metal substrate oxidation at 1,100 °С. SPS sintered anodes demonstrate sufficiently homogeneous distribution of NiO and YSZ making a conduction path for electrons and ions. Well-bonded metal support/anode interface was obtained.
Advancing Regional Integration in Africa through the Continental Free Trade Area (CFTA)
Authors: Ismail F. A. 
Published: May 2017

AbstractThe past decade and a half of the new millennium has ushered in dramatic changes to the architecture of world trade creating both opportunities and challenges for Africa’s development. The paper is critical of the recent paper of the World Bank that resuscitates the approach to trade liberalization and regional integration propagated by the Washington Consensus. The paper argues that African countries should adopt a “development integration” approach to regional integration that seeks to combine trade liberalization, industrial development and infrastructure development. The paper urges the World Bank and Africa’s trading partners from the north and south, such as the EU, the US and China, to work closely with the African Union to advance the negotiations and implementation of the Continental Free Trade Area (CFTA) and the African Union Agenda 2063.
Was macht der Buddha in einer altfriesischen Chronik?
Authors: Winter Franz 
Published: May 2017

Zusammenfassung
Der populäre „Laienforscher“ und „Pseudo-Gelehrte“ Herman Wirth (1885–1981) veröffentlichte 1933 eine Übersetzung und Interpretation eines Buches, das unter dem Titel Oera Linda Boek seit Ende des 19. Jh. bekannt war und ein angebliches Manuskript antiken Ursprungs zum Inhalt hatte. Darin findet sich eine phantastische Darstellung der angeblichen Frühgeschichte der Friesen, die in den Niederlanden entstand und möglicherweise von vorne herein als Parodie konzipiert worden war. In diesem Text findet sich unter anderem eine Referenz an den Buddha, der mit der Geschichte des Reiches von „Atland“ verbunden wird, einer angeblichen arischen Urheimat, wo auch der eigentliche Ursprung aller bedeutenden kulturellen und religiösen Entwicklungen liegen würde. Eine Interpretation dieser kuriosen Bezugnahme erlaubt Einblicke in Aspekte und Entwicklungen der rassischen und „völkischen“ Diskussion über und dessen Umgang mit Asien.
NS-Mystik und militanter Zen
Authors: Baier Karl 
Published: May 2017

Zusammenfassung
Der Aufsatz behandelt mit Karlfried Graf Dürckheim einen während des zweiten Weltkriegs in Japan höchst aktiven Propagandisten des Nationalsozialismus. Dürckheim verband sein Engagement für das Regime mit einer Mystik des Verschmelzens mit dem deutschen Volk und dem darin sich manifestierenden, von Dürckheim so genannten „göttlichen Weltgrund“. Während seiner Aufenthalte in Japan interessierte er sich immer mehr für den Zen, dessen militante, den japanischen Imperialismus unterstützende Ausprägung seiner NS-Mystik sehr entgegenkam. Im Fokus von Dürckheims Interesse stand seinem völkischen Denken entsprechend aber nicht diese Form des Buddhismus per se, sondern ihre positiven Auswirkungen auf das japanische Volk und den Erfolg des damaligen Regimes. Diesen Erfolg und die Machtentfaltung Japans deutet Dürckheim als Manifestation des Einklangs zwischen dem real existierenden Japan und seiner ewigen völkischen Essenz, die wiederum am Göttlichen teilhat – ein Einklang, zu dem Zen seinen Teil beiträgt.
Nun sag, wie hältst du’s mit der ‚Öffentlichkeit‘?
Authors: Jahn Sarah J. 
Published: May 2017

Zusammenfassung
Der Beitrag befasst sich mit Überlegungen zur Positionsbestimmung von Religionswissenschaft in der Öffentlichkeit. Ausgehend von Rudolphs Auseinandersetzung über die ideologiekritische Funktion von Religionswissenschaft (1978) wird anhand der Positionen von Tworuschka (2008, 2015), McCutcheon (2001), Wilke (2005), Seiwert (1998) und Klinkhammer (2001) deutlich, dass die aktuelle Gretchenfrage nicht neu ist, es im Gegenteil schon konkrete, aber auch divergente Aussagen über die Rolle von Religionswissenschaft in der Öffentlichkeit gibt. Dem Verständnis einer historisch-kritisch arbeitenden und sich methodologisch-agnostisch verstehenden Religionswissenschaft folgend, wird ein Vorschlag unterbreitet, der den einseitigen Prozess der Wissensvermittlung hin zu einem wechselseitigen auflöst.
Cardiovascular events in patients with mild autonomous cortisol secretion: analysis with artificial neural networks
Authors: Morelli Valentina , Palmieri Serena , Lania Andrea , Tresoldi Alberto , Corbetta Sabrina , Cairoli Elisa , Eller-Vainicher Cristina , Arosio Maura , Copetti Massimiliano , Grossi Enzo , Chiodini Iacopo 
Published: May 2017

Background
The independent role of mild autonomous cortisol secretion (ACS) in influencing the cardiovascular event (CVE) occurrence is a topic of interest. We investigated the role of mild ACS in the CVE occurrence in patients with adrenal incidentaloma (AI) by standard statistics and artificial neural networks (ANNs).

Methods
We analyzed a retrospective record of 518 AI patients. Data regarding cortisol levels after 1 mg dexamethasone suppression (1 mg DST) and the presence of obesity (OB), hypertension (AH), type-2 diabetes (T2DM), dyslipidemia (DL), familial CVE history, smoking habit and CVE were collected.

Results
The receiver-operating characteristic curve analysis suggested that 1 mg DST, at a cut-off of 1.8 µg/dL, had the best accuracy for detecting patients with increased CVE risk. In patients with 1 mg-DST ≥1.8 µg/dL (DST+, n = 223), age and prevalence of AH, T2DM, DL and CVE (66 years, 74.5, 25.9, 41.4 and 26.8% respectively) were higher than that of patients with 1 mg-DST ≤1.8 µg/dL (61.9 years, 60.7, 18.5, 32.9 and 10%, respectively, P < 0.05 for all). The CVE were associated with DST+ (OR: 2.46, 95% CI: 1.5–4.1, P = 0.01), regardless of T2DM, AH, DL, smoking habit, gender, observation period and age. The presence of at least two among AH, T2DM, DL and OB plus DST+ had 61.1% sensitivity in detecting patients with CVE. By using the variables selected by ANNs (familial CVE history, age, T2DM, AH, DL and DST+) 78.7% sensitivity was reached.

Conclusions
Cortisol after 1 mg-DST is independently associated with the CVE occurrence. The ANNs might help for assessing the CVE risk in AI patients.
Implicaciones de la concepción de planificación por proyectos desde la perspectiva de actores educativos venezolanos
Authors: Pasek-de Pinto Eva Lidmila , Villamil-de Vásquez Teresita , Ávila-de Vanegas Nelly 
Published: May 2017

This article is the result of a research project which aimed to infer educational, epistemological, political and transforming implications from the conceptions educational stakeholders have about planning for projects. The study was addressed from the phenomenological philosophical school perspective with a qualitative methodology based on interviews. Following Rodríguez et al. (1999), the research was conducted in four stages: the preparatory phase, the field work, the analysis, and the information phase. In-depth interviews were carried out with three principals, eight teachers, four representatives and two students. The information gathered was transcribed, organized, codified, categorized by concepts, interpreted and triangulated. The results indicated that educational stakeholders understand planning by projects like a vision, an orderly sequence of steps, a collective action, an intention of achievement, a strategy, and a goal. From these ideas derived educational, epistemological, and political implications for change. It is concluded that the conceptions of educational stakeholders on planning for projects render difficult an education for a participatory democracy, for action, and for change, limiting the formation of the new cooperative and responsible citizenship. Therefore it is suggested to train teachers for participation since they ensure the educational process.
A hyponatraemia ritka oka: McKittrick–Wheelock-szindróma
Authors: Nagy Rita , Márkus Csaba , Jáger László , Tóth Csaba , Lőcsei Zoltán 
Published: May 2017

Abstract: Authors present a case of acute renal failure and hyponatraemia caused by a secretory tubulovillous adenoma of the colon, the rare so called McKittrick-Wheelock syndrome. A 75 year old woman was in need of treatment many times on medical wards because of watery diarrhoea, severe dehydration, hydroelectrolyte disturbance. The authors keep their case to be worthy to present, owing to the syndrome’s rarity and difficulties of differential diagnosis. Orv Hetil. 2017; 158(18): 711–714.
The Paradox of Global Civil Society
Authors: Dzwończyk Joanna 
Published: May 2017

The article presents the issue of global civil society, which is often regarded as a kind of remedy for global problems. It has been pointed out that civil society is inextricably linked with the institution of the state, as well as democracy, which is not conducive to globalisation. As a strictly verbal structure, the global civil society cannot actually be brought into existence, mainly due to the lack of a universal / global axiological foundation. Referring to attempts to create a global civil society, the author points out that it can become a construct that exists ostensibly to address problems which could be addressed by entities with a real ability to act, but which cannot or do not want to. These are problems best not ignored. Referring to Roland Robertson’s concept of glocalisation, I stress the need to re-evaluate the local-global relation, which I believe will reduce the negative effects of globalisation through the local activities (i.e. operating at the level of the nationstate) of civil societies.
Prospective Evaluation of the Relationship Between Mechanical Stability and Response to Palliative Radiotherapy for Symptomatic Spinal Metastases
Authors: van der Velden Joanne M. , Versteeg Anne L. , Verkooijen Helena M. , Fisher Charles G. , Chow Edward , Oner F. Cumhur , van Vulpen Marco , Weir Lorna , Verlaan Jorrit-Jan 
Published: May 2017

Abstract

Background
A substantial number of patients with spinal metastases experience no treatment effect from palliative radiotherapy. Mechanical spinal instability, due to metastatic disease, could be associated with failed pain control following radiotherapy. This study investigates the relationship between the degree of spinal instability, as defined by the Spinal Instability Neoplastic Score (SINS), and response to radiotherapy in patients with symptomatic spinal metastases in a multi-institutional cohort.

Methods and Materials
The SINS of 155 patients with painful thoracic, lumbar, or lumbosacral metastases from two tertiary hospitals was calculated using images from radiotherapy planning CT scans. Patient-reported pain response, available for 124 patients, was prospectively assessed. Pain response was categorized, according to international guidelines, as complete, partial, indeterminate, or progression of pain. The association between SINS and pain response was estimated by multivariable logistic regression analysis, correcting for predetermined clinical variables.

Results
Of the 124 patients, 16 patients experienced a complete response and 65 patients experienced a partial response. Spinal Instability Neoplastic Score was associated with a complete pain response (adjusted odds-radio [ORadj] 0.78; 95% confidence interval [CI] 0.62–0.98), but not with an overall pain response (ORadj 0.94; 95% CI 0.81–1.10).

Conclusions
A lower SINS, indicating spinal stability, is associated with a complete pain response to radiotherapy. This supports the hypothesis that pain resulting from mechanical spinal instability responds less well to radiotherapy compared with pain from local tumor activity. No association could be determined between SINS and an overall pain response, which might indicate that this referral tool is not yet optimal for prediction of treatment outcome.
Oratio: Address to Commemorate the 2013 Martin Luther King Day at the Law Faculty, University of Michigan
Authors: Govender Karthy 
Published: May 2017

The paper commences by considering the similarity between Dr King, MK Gandhi and Nelson Mandela and argues that they are high mimetic figures who inspire us to be better. Their legacy and memory operate as a yardstick by which we can evaluate the conduct of those exercising public and private power over us. Each remains dominant in his respective society decades after passing on or leaving public life, and the paper suggests that very little societal value is had by deconstructing their lives and judging facets of their lives through the prism of latter day morality. We gain more by leaving their high mimetic status undisturbed.

There is a clear link between their various struggles with King being heavily influenced by the writings and thinking of Gandhi, who commenced his career as a liberation activist in South Africa. King was instrumental in commencing the discourse on economic sanctions to force the Apartheid government to change and the Indian government had a long and committed relationship with the ANC.

The second half of the paper turns to an analysis of how Dr King's legacy impacted directly and indirectly on developments in South Africa. One of the key objectives of the Civil Rights movement in the USA was to attain substantive equality and to improve the quality of life of all. The paper then turns to assessing the extent to which democratic South Africa has achieved these objectives and concludes that the picture is mixed. Important pioneering changes such as enabling gays and lesbians to marry have taught important lessons about taking rights seriously. However, despite important advancements, neither poverty nor inequality has been appreciably reduced. One of the major failures has been the inability to provide appropriate, effective and relevant education to African children in public schools. Effectively educating previously disadvantaged persons represents one of the few means at our disposal of reducing inequality and breaking the cycle of poverty. Fortunately, there is a general awareness in the country that something needs to be done about this crisis urgently. The paper notes comments by President Zuma that the level of wealth in white households is six times that of black households. The critique is that comments of this nature do not demonstrate an acknowledgment by the ANC that, after 19 years in power, they must also accept responsibility for statistics such as this.