bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coronary pressure and flow relationships in humans: phasic analysis of normal and pathological vessels and the implications for stenosis assessment: a report from the Iberian–Dutch–English (IDEAL) collaborators
Authors: Nijjer Sukhjinder S. , de Waard Guus A. , Sen Sayan , van de Hoef Tim P. , Petraco Ricardo , Echavarría-Pinto Mauro , van Lavieren Martijn A. , Meuwissen Martijn , Danad Ibrahim , Knaapen Paul , Escaned Javier , Piek Jan J. , Davies Justin E. , van Royen Niels 
Published: November 2015

Abstract

Background
Our understanding of human coronary physiological behaviour is derived from animal models. We sought to describe physiological behaviour across a large collection of invasive pressure and flow velocity measurements, to provide a better understanding of the relationships between these physiological parameters and to evaluate the rationale for resting stenosis assessment.

Methods and results
Five hundred and sixty-seven simultaneous intracoronary pressure and flow velocity assessments from 301 patients were analysed for coronary flow velocity, trans-stenotic pressure gradient (TG), and microvascular resistance (MVR). Measurements were made during baseline and hyperaemic conditions. The whole cardiac cycle and the diastolic wave-free period were assessed. Stenoses were assessed according to fractional flow reserve (FFR) and quantitative coronary angiography DS%. With progressive worsening of stenoses, from unobstructed angiographic normal vessels to those with FFR ≤ 0.50, hyperaemic flow falls significantly from 45 to 19 cm/s, Ptrend &lt; 0.001 in a curvilinear pattern. Resting flow was unaffected by stenosis severity and was consistent across all strata of stenosis ( Ptrend &gt; 0.05 for all). Trans-stenotic pressure gradient rose with stenosis severity for both rest and hyperaemic measures ( Ptrend &lt; 0.001 for both). Microvascular resistance declines with stenosis severity under resting conditions ( Ptrend &lt; 0.001), but was unchanged at hyperaemia (2.3 ± 1.1 mmHg/cm/s; Ptrend = 0.19).

Conclusions
With progressive stenosis severity, TG rises. However, while hyperaemic flow falls significantly, resting coronary flow is maintained by compensatory reduction of MVR, demonstrating coronary auto-regulation. These data support the translation of coronary physiological concepts derived from animals to patients with coronary artery disease and furthermore, suggest that resting pressure indices can be used to detect the haemodynamic significance of coronary artery stenoses.
Projecting marine fish production and catch potential in Bangladesh in the 21st century under long-term environmental change and management scenarios
Authors: Fernandes Jose A. , Kay Susan , Hossain Mostafa A. R. , Ahmed Munir , Cheung William W. L. , Lazar Attila N. , Barange Manuel 
Published: November 2015

AbstractThe fisheries sector is crucial to the Bangladeshi economy and wellbeing, accounting for 4.4% of national gross domestic product and 22.8% of agriculture sector production, and supplying ca. 60% of the national animal protein intake. Fish is vital to the 16 million Bangladeshis living near the coast, a number that has doubled since the 1980s. Here, we develop and apply tools to project the long-term productive capacity of Bangladesh marine fisheries under climate and fisheries management scenarios, based on downscaling a global climate model, using associated river flow and nutrient loading estimates, projecting high-resolution changes in physical and biochemical ocean properties, and eventually projecting fish production and catch potential under different fishing mortality targets. We place particular interest on Hilsa shad (Tenualosa ilisha), which accounts for ca. 11% of total catches, and Bombay duck (Harpadon nehereus), a low price fish that is the second highest catch in Bangladesh and is highly consumed by low-income communities. It is concluded that the impacts of climate change, under greenhouse emissions scenario A1B, are likely to reduce the potential fish production in the Bangladesh exclusive economic zone by &lt;10%. However, these impacts are larger for the two target species. Under sustainable management practices, we expect Hilsa shad catches to show a minor decline in potential catch by 2030 but a significant (25%) decline by 2060. However, if overexploitation is allowed, catches are projected to fall much further, by almost 95% by 2060, compared with the Business as Usual scenario for the start of the 21st century. For Bombay duck, potential catches by 2060 under sustainable scenarios will produce a decline of &lt;20% compared with current catches. The results demonstrate that management can mitigate or exacerbate the effects of climate change on ecosystem productivity.
Ghost in the time series: no planet for Alpha Cen B
Authors: Rajpaul V. , Aigrain S. , Roberts S. 
Published: November 2015

Abstract
We re-analyse the publicly available radial velocity (RV) measurements for Alpha Cen B, a star hosting an Earth-mass planet candidate, Alpha Cen Bb, with 3.24 d orbital period. We demonstrate that the 3.24 d signal observed in the Alpha Cen B data almost certainly arises from the window function (time sampling) of the original data. We show that when stellar activity signals are removed from the RV variations, other significant peaks in the power spectrum of the window function are coincidentally suppressed, leaving behind a spurious yet apparently significant ‘ghost’ of a signal that was present in the window function's power spectrum ab initio. Even when fitting synthetic data with time sampling identical to the original data, but devoid of any genuine periodicities close to that of the planet candidate, the original model used to infer the presence of Alpha Cen Bb leads to identical conclusions: viz., the 3σ detection of a half-a-metre-per-second signal with 3.236 d period. Our analysis underscores the difficulty of detecting weak planetary signals in RV data, and the importance of understanding in detail how every component of an RV data set, including its time sampling, influences final statistical inference.
A phylogenetically diverse class of “blind” type 1 opsins
Authors: Becker Erin A. , Yao Andrew I. , Seitzer Phillip M. , Kind Tobias , Wang Ting , Eigenheer Rich , Shao Katie S. Y. , Yarov-Yarovoy Vladimir , Facciotti Marc T. 
Published: November 2015

AbstractOpsins are photosensitive proteins catalyzing light-dependent processes across the tree of life. For both microbial (type 1) and metazoan (type 2) opsins, photosensing depends upon covalent interaction between a retinal chromophore and a conserved lysine residue. Despite recent discoveries of potential opsin homologs lacking this residue, phylogenetic dispersal and functional significance of these abnormal sequences have not yet been investigated. We report discovery of a large group of putatively non-retinal binding opsins, present in a number of fungal and microbial genomes and comprising nearly 30% of opsins in theHalobacteriacea, a model clade for opsin photobiology. Based on phylogenetic analyses, structural modeling, genomic context and biochemistry, we propose that these abnormal opsin homologs represent a novel family of sensory opsins which may be involved in taxis response to one or more non-light stimuli. This finding challenges current understanding of microbial opsins as a light-specific sensory family, and provides a potential analogy with the highly diverse signaling capabilities of the eukaryotic G-protein coupled receptors (GPCRs), of which metazoan type 2 opsins are a light-specific sub-clade.
The COBRA fixed-wing georeferenced imagery dataset
Authors: Saeedi Sajad , Thibault Carl , Trentini Michael , Li Howard 
Published: November 2015

Purpose
– The purpose of this paper is to present a localization and mapping data set acquired by a fixed-wing unmanned aerial vehicle (UAV). The data set was collected for educational and research purposes: to save time in dealing with hardware and to compare the results with a benchmark data set. The data were collected in standard Robot Operating System (ROS) format. The environment, fixed-wing, and sensor configuration are explained in detail. GPS coordinates of the fixed-wing are also available as ground truth. The data set is available for download (www.ece.unb.ca/COBRA/open_source.htm).

Design/methodology/approach
– The data were collected in standard ROS format. The environment, fixed-wing, and sensor configuration are explained in detail.

Findings
– The data set can be used for target localization and mapping. The data were collected to assist algorithm developments and help researchers to compare their results. Robotic data sets are specifically important when they are related to unmanned systems such as fixed-wing aircraft.

Originality/value
– The Robotics Data Set Repository (RADISH) by A. Howard and N. Roy hosts 41 well-known data sets with different sensors; however, there is no fixed-wing data set in RADISH. This work presents two data sets collected by a fixed-wing aircraft using ROS standards. The data sets can be used for target localization and SLAM.
Comment sifting: pragmatic qualitative analysis of LibQUAL + Comments
Authors: Luther Michael 
Published: November 2015

Purpose
– The purpose of this paper is to present a practical, low-tech and adaptable methodology for converting large amounts of comment data into actionable, qualitative analysis.

Design/methodology/approach
– In 2013, the Horace W. Sturgis Library of Kennesaw State University conducted the LibQUAL+ survey, receiving 1,653 open-ended comments. In a home-grown approach to comment analysis, the Sturgis Library targeted specific areas of operational significance (chat, ILL, etc.) to analyze in depth. Keywords and synonyms were identified, comments containing these terms were evaluated and a document known as a mini-report summarized the analysis for each area.

Findings
– Over the summer of 2013, two librarians created 12 mini-reports. The mini-report format allowed investigators to build up their understanding of the organization incrementally and proved a valuable means of summarizing qualitative analysis and sharing it with various stakeholders.

Research limitations/implications
– Not all comments are coded, and therefore, potentially valuable information is lost. By limiting focus to specific operational areas, the methodology does not capture themes that are diffused throughout the organization. Some areas of operational significance are difficult to isolate by keywords.

Originality/value
– This paper contributes to the literature on pragmatic qualitative analysis. Many existing models of qualitative analysis are resource intensive, in terms of time, technology and staff training. This paper presents a variation on a methodology that is more adaptable, allowing the researchers to explore within large pools of comment data without having to code and analyze every comment.
Google classroom for librarians: features and opportunities
Authors: Izenstark Amanda , Leahy Katie L. 
Published: November 2015

Purpose
– The purpose of this paper is to share possible opportunities for librarians, faculty and students with access to Google Classroom, and it includes a discussion of its application and functionality in information literacy sessions.

Design/methodology/approach
– This paper describes the functionality of Google Classroom with a review of its capabilities for providing information literacy instruction based on hands-on use in several classes and observation.

Findings
– Google Classroom streamlined delivery of materials with students in one-time and multi-meeting classes. Students appreciated its seamless integration with their university email accounts.

Originality/value
– Librarians teaching classes often need to share introductory information, exercises and supplemental materials with students. Google Classroom offers a simple platform for this purpose.
National Hockey League guaranteed contracts
Authors: Landry Jon , Edgar David , Harris John , Grant Kevin 
Published: November 2015

Purpose
– This paper aims to investigate, through the lens of the principal–agent problem, the relationship between payment of National Hockey League (NHL) salaries and player performance during the period of 2005-2011 and explore the inherent issues within the NHL player compensation and incentive structure.

Design/methodology/approach
– The research adopts a pragmatic philosophy with deductive reasoning. This paper focuses on the NHL season 2005-2011 and undertake analysis of historical player contracts and performance data of 670 players across 29 clubs to undertake liner regression analysis.

Findings
– This paper quantifies potential inefficiencies of NHL league contracts and defines the parameters of the principal–agent problem. It is identifies that player performance generally increases with salary, is higher in the first year of a contract and despite decreasing over the life of the contract, will usually peak again in the final year of the contract.

Research limitations/implications
– The research is based around figures from 2005-2011 and secondary statistical data. The study captures quantitative data but does not allow for an exploration of the qualitative perspective to the problem.

Practical implications
– Entry-level or first contracts are good for all teams and players because they provide incentive to perform and a reduction of risk to the team should a player not perform to expectations. The same can be said for players at the other end of the spectrum. Although not typically used much, performance bonuses for players over the age of 35 allow clubs to “take a chance” on a player and the player can benefit by reaching attainable bonuses. These findings therefore provide contributions to the practicing managers and coaches of NHL teams who can consider the results to help shape their approach to management of players and the planning of teams and succession planning for talent.

Originality/value
– The paper presents a comprehensive and current perspective of the principal–agent problem in NHL and extends the work of Purcell (2009) and Gannon (2009) in understanding player performance enhancement.
Financial distress at Comercial Mexicana, 2008-2011
Authors: Trejo-Pech Carlos Omar , White Susan , Noguera Magdy 
Published: November 2015

Synopsis
Controladora Comercial Mexicana, a Mexican retailer, had successfully managed the bankruptcy process and was ready to emerge from its problems, primarily caused by speculation and excessive debt, and begin operations anew. Was the restructured Comerci capable of regaining its position as a premier retailer, and more importantly, was the firm capable of repaying the high level of debt that it carried following bankruptcy reorganization? How strong was the reorganized firm? Had Comerci truly left its problems behind in bankruptcy court, or would history repeat itself? How could Comerci raise funds needed for growth – through additional debt? Though asset sales?

Research methodology
This case was researched using publicly available information, including the company's financial statements, bankruptcy filings, news stories about the bankruptcy and financial data bases (e.g. ISI Emerging Markets, Economática, Capital IQ, etc.) to obtain information about the competitors and from financial analysts.

Relevant courses and levels
This case is intended for advanced undergraduate or MBA electives in finance. Students should have a basic understanding of valuation and financing before attempting this case. The case could also be used in a corporate finance or banking class to illustrate bankruptcy and credit risk, or could be used in an international business class to illustrate the differences between USA and international bankruptcies.
Kumnandzi Macadamia Importers: cracking the nut of self-identity
Authors: Timmerman John , Morris Frank , Lovvorn Al 
Published: November 2015

Synopsis
Steve Holder had already worked with Matsapha College for ten years as the organization matured its macadamia orchard to the point of yielding sufficient proceeds to assist in the support of the colleges educational endeavors in Swaziland. Now Matsapha College was entertaining the possibility of launching a separate entity, Kumnandzi Macadamia Importers, to be a stateside distributor of both Matsapha's macadamia nuts and that of other growers in the region, with the prospect of producing additional revenue to help sponsor education. The Board of Matsapha College is interested in the idea of having the College prosper from added macadamia sales, but members have mixed opinions about the direction and form this growth should take. Before any major decisions are made, Steve learns that the organization should do some self-reflection and decide what Kumnandzi Macadamia Importers is all about before proceeding. Specifically, the Matsapha College Board of Directors needs to articulate its vision for the proposed new entity, as well as craft the entity's mission statement and value proposition.

Research methodology
The case was based upon extensive interviews with the President of the organization being described.

Relevant courses and levels
This case is targeted to both undergraduate and graduate students in Strategic Management, but may include Marketing Principles, Marketing Management, Strategic Marketing, and Entrepreneurship, especially if the course includes the task of building a business plan or marketing plan that incorporates vision and mission statements as well as a customer value proposition.
Eastern Truss Company: the technology adoption decision
Authors: Ritchie William , Williamson Dusty , Ni John , Shahzad Ali , Young George 
Published: November 2015

Synopsis
Located in the Mid-Atlantic region of the United States, Eastern Truss Company produced trusses used in construction of both large warehouses and custom homes. This case presents the student with the opportunity to analyze the critical factors associated with the decision of whether Eastern should adopt a new production technology and whether cash flows from reduction of temporary workers will cover adoption coasts. The student must evaluate the decision to adopt the production technology through the lens of operations management tools. This case is appropriate for undergraduate business studies in the field of operations management.

Research methodology
Case study.

Relevant courses and levels
Undergraduate operations management.
Mystic landscaping: selecting a form of business ownership
Authors: Vega Gina 
Published: November 2015

Synopsis
This case provides information about the start-up of a successful landscaping/snow plowing business by a high school student. A description of some of the characteristics of the entrepreneur, his method of gaining start-up funds, and suggestions about the way he focused himself on his goals offer food for thought to students about the start-up process and selection of an appropriate form of business ownership.

Research methodology
Primary research.

Relevant courses and levels
This case is designed for use by undergraduates in introduction to entrepreneurship, entrepreneurial finance, or introduction to business classes. It can be introduced early in the term to encourage discussion of launching a business.
Isoform‐specific regulation of transforming growth factor‐β mRNA expression in macrophages in response to adrenoceptor stimulation
Authors: Yanagawa Yoshiki , Hiraide Sachiko , Iizuka Kenji 
Published: November 2015

ABSTRACTTransforming growth factor‐beta (TGF‐β) is a multifunctional cytokine responsible for both immune regulation and tissue repair. Although TGF‐β consists of TGF‐β1, ‐β2, and ‐β3 in mammals, isoform‐selective transcriptional regulation is less well documented in myeloid linage cells such as macrophages. In the present study, the effect of the stress‐related catecholamine adrenaline on the expression of TGF‐β isoforms in RAW264.7 macrophages and murine bone marrow‐derived macrophages was examined. Treatment with adrenaline markedly increased the mRNA expression of TGF‐β3 but not of TGF‐β1 and ‐β2. Agonist and antagonist studies indicated that adrenaline‐induced TGF‐β3 mRNA expression is mediated via β2‐adrenoceptor. Protein kinase A (PKA) inhibitor H89 was found to block an increase in adrenoceptor‐mediated TGF‐β3 mRNA expression. The membrane‐permeable cAMP analog 8‐Br‐cAMP increased the mRNA expression of TGF‐β3 but not of TGF‐β1 and ‐β2. Thus, the β2‐adrenoceptor‐mediated cAMP‐PKA pathway appears to enhance TGF‐β3 mRNA expression in macrophages. Adrenoceptor‐mediated TGF‐β3 expression by macrophages may influence immune regulation and tissue repair in conditions of stress, during which the sympathetic‐nervous system releases catecholamines.
A 350‐million‐year legacy of fire adaptation among conifers
Authors: He Tianhua , Belcher Claire M. , Lamont Byron B. , Lim Sim L. 
Published: November 2015

Summary

Current phylogenetic evidence shows that fire began shaping the evolution of land plants 125 Ma, although the fossil charcoal record indicates that fire has a much longer history (>350 Ma). Serotiny (on‐plant seed storage) is generally accepted as an adaptation to fire among woody plants.

We developed a conceptual model of the requirements for the evolution of serotiny, and propose that serotiny is only expressed in the presence of a woody rachis as supporting structure, compact scales covering seeds as protective structure, seed wing as dispersal structure, and crown fire as the agent of selection and mechanism for seed release. This model is strongly supported by empirical data for modern ecosystems.

We reconstructed the evolutionary history of intrinsic structural states required for the expression of serotiny in conifers, and show that these were diagnostic for early (‘transitional’) conifers from 332 Ma (late‐Carboniferous).

We assessed the likely flammable characteristics of early conifers and found that scale‐leaved conifers burn rapidly and with high intensity, supporting the idea that crown fire regimes may have dominated early conifer ecosystems.

Synthesis. Coupled with strong evidence for frequent fire throughout the Permian‐Carboniferous and fossil evidence for other fire‐related traits, we conclude that many early conifers were serotinous in response to intense crown fires, indicating that fire may have had a major impact on the evolution of plant traits as far back as 350 Ma.
Sensory quality of unheated and heated Mozzarella‐style cheeses with different fat, salt and calcium levels
Authors: Henneberry Sarah , O'Sullivan Maurice G , Kilcawley Kieran N , Kelly Philip M , Wilkinson Martin G , Guinee Timothy P 
Published: November 2015

The current study evaluated the effects of reducing fat from 23w/w to 11w/w and salt from 1.8 to 1.0w/w on the texture profile attributes, volatile compounds and sensory characteristics of unheated and heated (95 °C) mozzarella‐style cheese after 15 and 35 days of storage at 4 °C. Reducing fat content significantly impaired sensory acceptability, mainly because of associated increases in firmness, rubberiness and chewiness, and reductions in fat flavour and cheese flavour in the unheated and heated cheeses. Reducing salt content had relatively minor effects. Reducing calcium content counteracted some of the negative sensory attributes associated with reduced‐fat cheese.