bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract LB-178: The impact of the gut microbiome on the antitumor effects of radiotherapy
Authors: Facciabene Andrea , Rafail Stavros , Uribe-Herranz Mireia , Pierini Stefano , Bittinger Kile , Verginadis Iannis , Koumenis Costas , Maity Amit 
Published: July 2017

Abstract
The sheer enormity of the microbial biomass in the human intestinal tract, the co-evolution between humans and the microbiota, and the established function of the gut microbes in regulating normal host physiologic functions, are all consistent with the idea that alterations in gut microbial ecology play a role in the pathophysiology of several conditions including cancer. Radiotherapy (RT) is an established curative and palliative cancer treatment regimen, with approximately half of cancer patients with solid tumors receiving RT some time during their disease. Mounting evidence also suggests that high-dose (hypofractionated) radiation exerts potent immune modulatory effects, prompting immunological active tumor cell death inducing tumor associated antigen (TAA) cross priming with elicitation of anti-tumor CD8+ T cells, and abscopal effects. Although there have been groundbreaking responses to immunotherapy in certain malignancies such as lung cancer and melanomas, so far, immunotherapy is effective only in a portion of patients19. This raises the issue of whether there are additional important regulators of T cell function that are relevant to tumor control and could be harnessed to enhance radiotherapy. In support of this hypothesis, we have generated preliminary results demonstrating that: a) Treatment with vancomycin, an antibiotic with action in the gut mostly against Gram+ bacteria, significantly increased the presence of overall tumor infiltrating T cells or cytotoxic CD8+ cells in tumors from mice treated with RT/vancomycin combination compared to RT alone; b) vancomycin caused a significant enhancement of the tumor inhibitory effect of targeted radiation. c) Vancomycin enhanced the ability of RT to increase the expression of IFN-g in CD8+ infiltrating T cells and antigen presentation in the tumor draining lymph nodes and d) the observed synergy between vancomycin and RT in eliciting an anti-tumor immune response and inhibiting tumor growth was abrogated in IFN-g KO animals or by CD8+ cell depletion.
Citation Format: Andrea Facciabene, Stavros Rafail, Mireia Uribe-Herranz, Stefano Pierini, Kile Bittinger, Iannis Verginadis, Costas Koumenis, Amit Maity. The impact of the gut microbiome on the antitumor effects of radiotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr LB-178. doi:10.1158/1538-7445.AM2017-LB-178
Association Between High‐Sensitivity Cardiac Troponin I and Cardiac Events in Elderly Women
Authors: Lewis Joshua R. , Lim Wai H. , Wong Germaine , Abbs Samuel , Zhu Kun , Lim Ee M. , Thompson Peter L. , Prince Richard L. 
Published: July 2017

Background

Elderly women are at high risk of coronary heart disease (
CHD
) and heart failure. High‐sensitivity assays allow detection of cardiac troponin I (hsTnI) well below diagnostic cutoffs for acute coronary syndrome. We investigated the association between these levels with future cardiac events in community‐based ambulant white women aged over 70 years initially recruited for a 5‐year randomized, controlled trial of calcium supplements.

Methods and Results

This was a prospective study of 1081 elderly women without clinical
CHD
at baseline (1998) or hsTnI above the diagnostic cutoffs for acute coronary syndrome with 14.5‐year follow‐up hospitalization and mortality (events). Two hundred forty‐three (22%) women had
CHD
events, 163 (15%) myocardial infarction or
CHD
death (hard
CHD
), and 109 (10%) heart failure. In 99.6% of available serum samples, hsTnI was above the level of detection (median, 4.5 ng/L; interquartile range, 3.6–5.8). After adjusting for Framingham risk factors, each
SD
natural log‐transformed hsTnI increase was associated with an increased hazard for
CHD
(hazard ratio, 1.34; 95%
CI
, 1.18–1.53;
P
<0.001) hard
CHD
(hazard ratio, 1.51; 95%
CI
, 1.29–1.76;
P
<0.001), and heart failure (hazard ratio, 1.65; 95%
CI
, 1.36–1.99;
P
<0.001). Step‐wise increases in relative hazards were observed with increasing quartiles of hsTnI (
P
for trend, <0.001), whereas the addition of hsTnI to conventional risk factors modestly improved discrimination indices: Harrell's c‐statistic, net reclassification, and integrated discrimination (
P
<0.05).

Conclusions
Cardiac troponin I is independently associated with future cardiac events in elderly women without apparent clinical manifestations. The addition of cardiac troponin I to conventional risk factors may modestly improve risk prediction in this setting.
Using the Artificial Tracer e90 to Examine Present and Future UTLS Tracer Transport in WACCM
Authors: Abalos Marta , Randel William J. , Kinnison Douglas E. , Garcia Rolando R. 
Published: July 2017

Abstract
Large-scale tracer transport in the upper troposphere and lower stratosphere (UTLS) is investigated using simulations of the Whole Atmosphere Community Climate Model (WACCM) over the period 1955–2099. The analyses are based on e90, an artificial passive tracer with constant emissions and atmospheric loss rates. The separate contributions of advection by the residual circulation, eddy mixing, and subgrid convection to total transport are explicitly evaluated. The results highlight distinct large-scale transport regimes in the tropics, characterized by efficient vertical tracer transport, and the extratropics, dominated by isentropic mixing. One novel result is the important role of vertical eddy mixing in the tropical upper troposphere. It is shown that interannual variability in e90 is largely driven by El Niño–Southern Oscillation and the quasi-biennial oscillation. The long-term trends emphasize a strong impact of a rising tropopause with climate change on UTLS dynamics and tracer transport. The analyses directly attribute the e90 trends to changes in the different transport components. Stronger residual circulation in the future leads to increased tracer concentrations in the tropical lower stratosphere. Enhanced eddy mixing increases e90 in the extratropical lowermost stratosphere, linked to an upward shift of wave dissipation tied to the tropopause rise. In the troposphere, reduced concentrations in the future are due to weaker convective transport out of the boundary layer and weaker extratropical isentropic eddy mixing.
Effects of Koshu Seamount on the Development of Baroclinic Instability Leading to the Kuroshio Large Meander
Authors: Tanaka Yuki , Hibiya Toshiyuki 
Published: July 2017

AbstractThe Kuroshio south of Japan shows bimodal path fluctuations between the large meander (LM) path and the nonlarge meander (NLM) path. The transition from the NLM path to the LM path is triggered by a small meander generated off southwestern Japan. The small meander first propagates eastward (downstream) along the Kuroshio and then rapidly amplifies over Koshu Seamount, located about 200 km south of Japan, leading to the formation of the LM path of the Kuroshio. Although Koshu Seamount is essential for the rapid amplification of the small meander, the underlying physical mechanism is not fully understood. In this study, the role of Koshu Seamount is revisited using a two-layer quasi-geostrophic model that takes into account the effects of bottom topography. Numerical experiments show that the transition from the NLM path to the LM path can be successfully reproduced only when bottom topography mimicking Koshu Seamount is incorporated. In this case, the upper-layer meander trough is rapidly amplified together with a lower-layer anticyclone by baroclinic instability during their passage over the northern slope of Koshu Seamount. A linear stability analysis shows that baroclinic instability over a seamount is caused by resonant coupling between the upper-layer Rossby wave in the eastward background flow and the lower-layer seamount-trapped wave during their eastward propagation over the northern slope of the seamount. The spatial scale and structure of this baroclinically unstable mode are close to those of the numerically reproduced small meander in its early amplification stage over the seamount.
Validation of fatigue damage model for composites made of various fiber types and configurations
Authors: Shahzad Asim , Nasir Sana Ullah 
Published: July 2017

Empirical model for predicting fatigue damage behavior of composite materials developed recently has been applied to composite materials made of different fibers in various configurations: carbon and glass fiber noncrimp fabric reinforced epoxy composites, chopped strand mat glass fiber-reinforced polyester composites, randomly oriented nonwoven hemp fiber-reinforced polyester composites, and glass/hemp fiber-reinforced polyester hybrid composites. The fatigue properties were evaluated in tension–tension mode at stress ratio R = 0.1 and frequency of 1 Hz. The experimental fatigue data were used to determine the material parameters required for the model. It has been found that the model accurately predicts the degradation of fatigue life of composites with an increase in number of fatigue cycles. The scope of applicability of this model has thus been broadened by using the fatigue data of natural fiber and noncrimp fabric composites.
Efficacy of parecoxib sodium on postoperative shivering: meta-analysis of clinical trials
Authors: Zhu Yu , Zhou Chengmao , Yang Yuting , Chen Yijian 
Published: July 2017

Objective To evaluate the effect of parecoxib on preventing postoperative shivering. Methods Main outcomes were the relative risk (odds ratio, OR) and 95% confidence interval (CI) relative to the incidence of shivering. Results Fourteen trials with 1,175 patients were analyzed. The pooled evidence suggested that parecoxib sodium, given before anesthesia or postoperatively (only 4 cases), had the potential to prevent postoperative shivering (OR = 0.21, 95% CI, 0.16, 0.29). Compared with the placebo, parecoxib sodium significantly lowered the incidence of postoperative shivering as follows: mild shivering [OR = 0.51, 95% CI (0.35, 0.74)]; moderate shivering [OR = 0.28, 95% CI (0.18, 0.45)]; severe shivering [OR = 0.18, 95% CI (0.10, 0.33)]. Compared with placebo, there was no significant association of parecoxib sodium with restlessness [OR = 0.95, 95% CI (0.59, 1.52)] or nausea/vomiting [OR = 0.24, 95% CI (0.09, 0.66)]. In addition, pethidine rescue was used significantly more often in the control group than in the parecoxib sodium group [OR = 0.22, 95% CI (0.09, 0.53)]. Conclusions Parecoxib sodium may be an effective strategy for preventing postoperative shivering.
A picture-based carbohydrate-counting resource for Somalis
Authors: Sunni Muna , Brunzell Carol , Kyllo Jennifer , Purcell Loren , Plager Phillip , Moran Antoinette 
Published: July 2017

Objective Carbohydrate counting is essential for effective management of type 1 diabetes (T1D). Somali diet-specific carbohydrate-counting references are lacking, creating an additional barrier to effective diabetes control. We developed a picture-based carbohydrate-counting resource for Somalis with T1D. Methods Traditional Somali foods were selected using a variety of methods. Serving sizes and carbohydrate calculations were tabulated using the United States Department of Agriculture National Nutrient Database for Standard Reference. Carbohydrate contents of home-prepared foods were calculated by measuring the total yield and total carbohydrates of ingredients in the recipe divided by the number of servings to be consumed. When available, recipes were used for food preparation and analysis for more accurate carbohydrate estimation. Results Photographs of prepared Somali foods were compiled into a PDF file. While introductions are written in text, the resource is primarily picture-based to bypass limited literacy. The resource is shared free of charge via the following link: http://journals.sagepub.com/doi/suppl/10.1177/0300060517718732 . The link will be updated annually with new information. Conclusion There is a necessity to tailor educational materials to address the needs of Somalis with diabetes. We have created a picture-based nutrition resource for carbohydrate counting of traditional Somali foods and have made this freely available to individuals worldwide.
Clinical profile of unclassifiable interstitial lung disease: Comparison with chronic fibrosing idiopathic interstitial pneumonias
Authors: Traila Daniel , Oancea Cristian , Tudorache Emanuela , Mladinescu Ovidiu Fira , Timar Bogdan , Tudorache Voicu 
Published: July 2017

Objective Unclassifiable interstitial lung disease (ILD) is a common problem in clinical practice. These patients pose a distinct challenge with regard to appropriate evaluation and management. We investigated the clinical features and prognosis of unclassifiable ILD and compared its clinical profile with that of idiopathic pulmonary fibrosis (IPF) and idiopathic nonspecific interstitial pneumonia (NSIP). Methods Patients with IPF (n = 40), NSIP (n = 14), and unclassifiable ILD (n = 27) were selected from an ongoing database. Baseline clinical features, pulmonary function, and the extent of fibrosis on high-resolution computed tomography (HRCT) were evaluated. Mortality was estimated based on the ILD–Gender, Age, Physiology (ILD-GAP) index and composite physiologic index (CPI). Results IPF was associated with the worst survival (hazard ratio [HR] = 4.361 compared with NSIP), followed by unclassifiable cases (HR = 1.251 compared with NSIP). Increasing mortality was significantly impacted by age (HR = 1.04 per 1-year increase), lower carbon monoxide diffusing capacity of the lung (HR = 0.97), HRCT interstitial score (HR = 1.119 per 1-point increase), ILD-GAP score (HR = 1.570 per 1-point increase), and CPI (HR = 1.039 per 1-point increase). Conclusions Patients with unclassifiable ILD had an intermediate prognosis between that of IPF and NSIP. Patients at high risk of mortality can be identified using baseline clinical, physiological, and radiological features.
Dehydroepiandrosterone supplementation in women undergoing assisted reproductive technology with poor ovarian response. A prospective case-control study
Authors: Al-Turki Haifa A. 
Published: July 2017

Objective The effects of dehydroepiandrosterone (DHEA) supplementation in Saudi Arabian women with poor ovarian response (POR) is presently unknown. The present study aimed to assess the benefits of DHEA supplementation in women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Methods This was a prospective case-control study involving 62 women who were diagnosed with POR and underwent IVF/ICSI between January 2012 and June 2016. The positive influence of DHEA in 34 women, compared with 28 women without supplementation, was defined as improvements in the number of oocytes retrieved, the fertilization rate, the number of grade I embryos generated and the pregnancy rate. Results Both groups were evenly matched for age, body mass index and laboratory test parameters. There were statistically significant differences between the groups with and without DHEA supplementation for oocyte yield (6.35 ± 2.41 versus 3.98 ± 3.2), Grade I embryos generated (55% versus 30%), positive pregnancy rate (21/34 versus 10/28), and live birth rate (18/34 versus 4/28). Conclusion DHEA supplementation in women with POR had a positive effect on hormonal profiles, the quality of the endometrium, the number of oocytes retrieved, the quality of embryos, and the pregnancy and live birth rates.
Double-plating fixation of comminuted femoral shaft fractures with concomitant thoracic trauma
Authors: Cheng Tao , Xia Ronggang , Yan Xiaoyu , Luo Congfeng 
Published: July 2017

Objective This study was performed to evaluate the clinical outcomes in adult polytraumatized patients with thoracic injury and femoral shaft fractures treated with double-plating fixation. Methods From November 2010 to October 2014, 15 polytraumatized patients with femoral shaft fractures were enrolled in this retrospective study. Radiographic findings and functional outcomes were assessed at 1, 3, 6, and 12 months postoperatively. Results Fourteen (93%) of the 15 femoral shaft fractures achieved bony union, with a mean time to union of 9.2 months. The mean Nonarthritic Hip Score and Lysholm Knee Score was 89.4 and 87.2 points, respectively. The range of motion of the knee joint was comparable between the injured and uninjured legs (116° and 121°, respectively). Conclusions Our findings suggest that lower limb function returns to normal after orthogonal double-plating fixation, which is an alternative technique to intramedullary nailing for femoral diaphyseal fractures in patients with severe chest injury.
Pregnancy outcome after anti-migraine triptan use: A prospective observational cohort study
Authors: Spielmann Kevin , Kayser Angela , Beck Evelin , Meister Reinhard , Schaefer Christof 
Published: July 2017

Objective The objective of our study is to assess the impact of triptan exposure on pregnancy outcome. Methods We performed a prospective observational cohort study with 432 pregnant women exposed to triptans and enrolled by the German Embryotox system. Pregnancy outcomes were compared with a migraine and a non-migraine comparison cohort. Primary objectives were major birth defects and spontaneous abortion; secondary endpoints were preterm delivery, birth weight, pregnancy complications and the rate of electively terminated pregnancies. Results Compared to a non-migraine cohort the rates of major birth defects (ORadj 0.84; 95% CI 0.4–1.9), spontaneous abortions (ORadj 1.20; 95% CI 0.9–1.7), preterm delivery (ORadj 1.01; 95% CI 0.7–1.5), and preeclampsia (ORadj 1.33; 95% CI 0.7–2.5) were not increased in triptan-exposed pregnancies. Conclusions Our findings support the evidence that triptans are not major teratogens. When compellingly needed during pregnancy, sumatriptan as the best studied triptan appears an acceptable treatment option. A detailed fetal ultrasound should be offered in cases of first trimester exposure to less well-studied triptans. Trial registration number in German Clinical Trials Register: DRKS00007660
Factors Influencing the Prevalence of Stunting Among Children Aged Below Five Years in Bangladesh
Authors: Sarma Haribondhu , Khan Jahidur Rahman , Asaduzzaman Mohammad , Uddin Fakhar , Tarannum Sayeeda , Hasan Md. Mehedi , Rahman Ahmed Shafiqur , Ahmed Tahmeed 
Published: July 2017

Background: Poor nutrition during childhood impedes physical and mental development of children, which propagate the vicious cycle of intergenerational under nutrition. This paper is aimed at understanding the determinants of stunting among children aged 0 to 59 months in Bangladesh. Methods: The study used Bangladesh Demographic and Health Survey 2011 data and a multistage stratified cluster-sampling design. Anthropometric data (for height and weight) were collected and analysis was limited to 7647 children. Multiple binary logistic regression analysis was performed to assess the association of stunting with potential socioeconomic and demographic factors. Results: The prevalence of stunting has been found to be about 41% among children aged less than 60 months and higher in rural setting than in urban areas (43% vs 36%). Adjusted model revealed that several factors were influencing stunting. The children living in moderately food-insecure households had higher odds of becoming stunted (odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.05-1.54, P = .01) compared to the children living in food-secure households. The derived ORs of stunting for children delivered at institutions facilitated particularly by public (OR = 0.80, 95% CI: 0.67-0.96; P = .02) or private (OR = 0.81, 95% CI: 0.67-0.97; P = .02) sectors were less than for children delivered at home. Similarly, wealth index, exposure of mother to the mass media, age of child, size of child at birth, and parents’ education were significantly associated with stunting. Conclusions: Moreover, the demographic characteristics and other indicators appeared to have significant influence in the prevalence of stunting. Public health programs are needed to avert the risk factors of stunting among children in Bangladesh.
Biomechanical Study of Screw Fixation and Plate Fixation of a Posterior Malleolar Fracture in a Simulation of the Normal Gait Cycle
Authors: Wang Xu , Yin Jianwen , Zhang Chao , Wang Chen , Geng Xiang , Ma Xin , Huang Jiazhang , Wang Chengwei , Wang Xue 
Published: July 2017

Background: Fixation of posterior malleolar fractures with plates or screws is under debate. A fatigue loading system and a spatial motion capture system were used in this study to evaluate a posterior malleolar fracture model. Methods: Thirty-six below-knee specimens with a single posterolateral fragment (Haraguchi I) type posterior malleolar fracture models were randomly divided into 2 groups. Two parallel-placed 3.5-mm partially threaded titanium alloy screws were used in Group A to fix the fractures, while anatomical plates were used in Group B. According to the ratio (S) of the area between the fracture and the total articular surface, each group was subdivided into 3 subgroups. In group A1 and B1, S=1/4; in A2 and B2, S=1/3; and in A3 and B3, S=1/2. To simulate the gait cycle, each specimen was subjected to mechanical loading in 4 different ankle positions. A fatigue loading system was used for repeated loading. A spatial motion capture system was used to measure the displacement in the final loading stage. Results: Despite the limited sample size and relatively low power, no significant difference was observed between A1 and B1, A2 and B2, and A3 and B3 in all 4 ankle positions after repeated loading. Conclusion: For a Haraguchi type I posterior malleolar fracture with an average height of 19 mm, fixation with a posterior malleolar anatomical plate failed to demonstrate a stronger strength than 2 parallel-placed 3.5-mm partially threaded screws, which indicates that plates may not be absolutely necessary for standard rehabilitation after posterior malleolar internal fixation. Clinical Relevance: These findings may help guide surgeons with regard to fixation requirements for posterior malleolar fractures.
Pathoanatomy and Associated Injuries of Posterior Malleolus Fracture of the Ankle
Authors: Mason Lyndon W. , Marlow William J. , Widnall James , Molloy Andrew P. 
Published: July 2017

Background: We present a classification system that progresses in severity, indicates the pathomechanics that cause the fracture and therefore guides the surgeon to what fixation will be necessary by which approach. Methods: The primary posterior malleolar fracture fragments were characterized into 3 groups. A type 1 fracture was described as a small extra-articular posterior malleolar primary fragment. Type 2 fractures consisted of a primary fragment of the posterolateral triangle of the tibia (Volkmann area). A type 3 primary fragment was characterized by a coronal plane fracture line involving the whole posterior plafond. Results: In type 1 fractures, the syndesmosis was disrupted in 100% of cases, although a proportion only involved the posterior syndesmosis. In type 2 posterior malleolar fractures, there was a variable medial injury with mixed avulsion/impaction etiology. In type 3 posterior malleolar fractures, most fibular fractures were either a high fracture or a long oblique fracture in the same fracture alignment as the posterior shear tibia fragment. Most medial injuries were Y-type or posterior oblique fractures. This fracture pattern had a low incidence of syndesmotic injury. Conclusion: The value of this approach was that by following the pathomechanism through the ankle, it demonstrated which other structures were likely to be damaged by the path of the kinetic energy. With an understanding of the pattern of associated injuries for each category, a surgeon may be able to avoid some pitfalls in treatment of these injuries. Level of Evidence: Level III, retrospective comparative series.