bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of hand motion during cadaveric mastoidectomy dissections: a technical note
Authors: On Thomas J. , Xu Yuan , Gonzalez-Romo Nicolas I. , Gomez-Castro Gerardo , Alcantar-Garibay Oscar , Santello Marco , Lawton Michael T. , Preul Mark C. 
Published: October 2024

BackgroundSurgical approaches that access the posterior temporal bone require careful drilling motions to achieve adequate exposure while avoiding injury to critical structures.ObjectiveWe assessed a deep learning hand motion detector to potentially refine hand motion and precision during power drill use in a cadaveric mastoidectomy procedure.MethodsA deep-learning hand motion detector tracked the movement of a surgeon's hands during three cadaveric mastoidectomy procedures. The model provided horizontal and vertical coordinates of 21 landmarks on both hands, which were used to create vertical and horizontal plane tracking plots. Preliminary surgical performance metrics were calculated from the motion detections.Results1,948,837 landmark detections were collected, with an overall 85.9% performance. There was similar detection of the dominant hand (48.2%) compared to the non-dominant hand (51.7%). A loss of tracking occurred due to the increased brightness caused by the microscope light at the center of the field and by movements of the hand outside the field of view of the camera. The mean (SD) time spent (seconds) during instrument changes was 21.5 (12.4) and 4.4 (5.7) during adjustments of the microscope.ConclusionA deep-learning hand motion detector can measure surgical motion without physical sensors attached to the hands during mastoidectomy simulations on cadavers. While preliminary metrics were developed to assess hand motion during mastoidectomy, further studies are needed to expand and validate these metrics for potential use in guiding and evaluating surgical training.
Evaluation of agreement for radiographic lesions and risk for racing in thoroughbred yearling sale repository radiographs
Authors: Argue Brodie J. , Ahern Benjamin J. 
Published: October 2024

IntroductionThe veterinary yearling pre-sale repository radiographs have the potential to impact both vendor and prospective purchaser. The primary aim of this study was to determine inter-observer agreement for orthopaedic lesions identified in thoroughbred yearling repository radiographs. A secondary goal was to determine agreement when using a pre-defined risk rating classification.MethodsThree experienced specialist equine surgeons (2 ACVS &amp; 1 FANZCVS) interpreted thirty repository radiographs once each for radiographic abnormalities. Each radiographic abnormality was given an associated risk assessment for future racing performance.ResultsThe use of a pre-defined risk rating grading scale resulted in good to excellent agreement as observers reached a consensus on risk ratings for lesions 97.1% of the time. The highest agreement was for the proximal interphalangeal joint and distal interphalangeal joint, with 99.9 and 98.2% agreement, respectively. The tarsal region was the joint with the highest disagreement with respect to pathology, with observers disagreeing 5.2% of the time.DiscussionThis study found that experienced veterinary surgeons reliably agreed on the absence of lesions but showed disagreement on the specific risk rating of common lesions.
Therapeutic effects of myrrh extract and myrrh-based silver nanoparticles on Trichinella spiralis-infected mice: parasitological, histopathological, and immunological (IFN-γ, IL-10, and MMP-9) investigations
Authors: Abd-ELrahman Salwa Mahmoud , Dyab Ahmed Kamal , Mahmoud Abeer El-sayed , Mohamed Shaymaa M. , Fouad Alamira Marzouk , Gareh Ahmed , Asseri Jamal , Dahran Naief , Alzaylaee Hind , Albisihi Hayat M. , Abd Elrahman Ahmed Mahmoud , Alsharif Fahd M. , Mostafa Heba , Hamad Nashwa , Elmahallawy Ehab Kotb , Elossily Nahed Ahmed 
Published: October 2024

IntroductionTrichinellosis, caused by Trichinella spiralis (T. spiralis), remains a prevalent parasitic zoonosis. Developing new drugs targeting and understanding the immune response against the infection is imperative. Previous research has inadequately explored the efficacy of crude myrrh extract and myrrh-based silver nanoparticles (AgNPs) against trichinellosis, as well as their impact on histopathological, and immunological factors.MethodsThis study evaluated the effects of silver nanoparticles biosynthesized using myrrh, crude myrrh extracts, and albendazole on the intestinal phase of T. spiralis. It also examined the associated histopathological changes and alterations in key immunological markers, including Interferon-gamma (IFN-γ), Interleukin-10 (IL-10), and Matrix Metalloproteinase-9 (MMP-9). Five groups of 12 mice were allocated as follows: group 1: non-infected, non-treated (negative control), group 2: infected, non-treated (positive control), group 3: infected and treated with biosynthesized silver nanoparticles (40 μg/mL), group 4: infected and treated with myrrh crude extract (800 mg/kg), and group 5: infected and treated with albendazole (50 mg/kg). Treatment was orally administered starting on the 2nd day post-infection and continued for three successive days. Mice of all groups were euthanized on the 6th day post-infection, and the intestine of each was isolated for parasitological, histopathological, and immunohistochemistry evaluation of MMP-9, as well as assessment of cytokines level (IFN-γ and IL-10 gene expressions) via Real-time PCR technique.ResultsThe present study showed a considerable reduction in adult worm count among the treated groups. The mortality rates of adult worms were 88.64% in the silver nanoparticles treated group, 85.17% in the myrrh crude extract group, and 94.07% in the albendazole-treated group. Histopathological examination revealed prominent alterations in the intestine of the infected non-treated mice, which were markedly restored by treatment. Immunohistochemical examination accompanied by significant reduction in MMP-9 expression in the infected mice treated with AgNPs compared to the infected non-treated group, reflecting the role of AgNPs in downgrading the inflammatory reaction in the intestine of infected mice.ConclusionCollectively, this study demonstrates the novel antiparasitic potential of silver nanoparticles biosynthesized with myrrh against T. spiralis in infected mice. The treatment was associated with moderate rise in IFN-γ gene expression and IL-10 expression, highlighting its therapeutic efficacy against T. spiralis.
mRNA expression profiles in muscle-derived extracellular vesicles of Large White and wild boar piglets reveal their potential roles in immunity and muscle phenotype
Authors: Yu Naixiang , Chang Xiaolong , Hu Jianchao , Li Jianjun , Ma Junwu , Huang Lusheng 
Published: October 2024

IntroductionExtracellular vesicles (EVs) known for their pivotal role in intercellular communication through RNA delivery, hold paramount implications for understanding muscle phenotypic variations in diverse pig breeds.MethodsIn this study, we compared the mRNA expression profiles of longissimus dorsi muscles and muscle-derived extracellular vesicles (M-EVs), and also examined the diversity of enriched genes in M-EVs between weaned wild boars and commercial Large White pigs with respect to their numbers and biological functions.ResultsThe results of the study showed that the variation in the expression profiles of mRNAs between muscles and M-EVs was much greater than the variability between the respective breeds. Meanwhile, the enrichment trend of low-expressed genes (ranked &lt;1,000) was significantly (p-value ≤ 0.05) powerful in M-EVs compared to highly expressed genes in muscles. In addition, M-EVs carried a smaller proportion of coding sequences and a larger proportion of untranslated region sequences compared to muscles. There were 2,110 genes enriched in M-EVs (MEGs) in Large White pigs and 2,322 MEGs in wild boars, with 1,490 MEGs shared interbreeds including cyclin D2 (CCND2), which inhibits myogenic differentiation. Of the 89 KEGG pathways that were significantly enriched (p-value ≤ 0.05) for these MEGs, 13 unique to Large White pigs were mainly related to immunity, 27 unique to wild boars were functionally diverse but included cell fate regulation such as the Notch signaling pathway and the TGF-beta signaling pathway, and 49 were common to both breeds were also functionally complex but partially related to innate immunity, such as the Complement and coagulation cascades and the Fc gamma R-mediated phagocytosis.DiscussionThese findings suggest that mRNAs in M-EVs have the potential to serve as indicators of muscle phenotype differences between the two pig breeds, highlighting the need for further exploration into the role of EV-RNAs in pig phenotype formation.
بلاغة المحاكاة وتمثيل الأفكار في الخطاب الروائي المعاصر نارنجة وسيدات القمر لجوخة الحارثي نموذجاً
Authors: شوشة محمد سليم محمد 
Published: October 2024

أهداف الدراسة: تهدف هذه الدراسة إلى مقاربة نواتج المحاكاة (Mimesis) والتمثيل (Representation) وأثرهما في بلاغة الخطاب الروائي عبر تطبيق على روايتي نارنجة وسيدات القمر للروائية العمانية جوخة الحارثي()، وتستكشف أثر المحاكاة والتمثيل في إنتاج جماليات الخطاب الروائي وسيرورة بنائه، وكذلك تركز الدراسة على السيرورة التحويلية التي اشتغل عليها الخطاب الروائي لتحويل قيمه الدلالية المجردة وتمثيلها في أحداث ونماذج وشخصيات وحركة وحوار يدور بين الشخصيات داخل الإطار الدرامي. منهج الدراسة: نستعين في تلك المقاربة بمعطيات النقد الأدبي الإدراكي الذي يركز على مبدئي المحاكاة والتمثيل بوصفهما من أهم مبادئ الأدب والفن بشكل عام، وكذلك الاستناد إلى معطيات علم السرد وتحليل الخطاب السردي وبلاغته، على نحو ما نجد في أفكار كل من وين بوث وإيريك أورباخ وبول ريكور وغيرهم. نتائج الدراسة: كان من نتائج البحث أن كشف عن المسار الذي يتخذه الخطاب الروائي والعقل السردي في تحويل الفكرة أو القيمة المجردة إلى تمثيل سردي أو تكوين مادي ملموس، فتتجسد الفكرة في شخصية أو حدث أو حالة من الصراع الدرامي، أو مشهد أو غيرها من المكونات والتقنيات السردية، كما كشفت الدراسة عن الأثر الناتج عن هذه الإستراتيجيات السردية المتمثلة في المحاكاة والتمثيل وتجسدها في (أثر/منتج تخييلي)، أو تشكيل داخل الخطاب السردي، وركزت الدراسة كذلك على النواتج الجمالية لهذه التقنيات، وما يمكن أن يكون لها من احتمالات تفاعل المتلقي وتأثير على أنماط استقباله. وامتدت نواتج هذه المقاربة إلى كشف تمثيلات الخطاب السردي وأنماط المحاكاة فيه وتحويل الأفكار إلى عنصر سردي، يتجسد في الأسطورة أو الخرافة أو الموروث الشعبي أو التراث الثقافي وحفريات الثقافة العمانية والعربية القديمة، وآثار ما بعد الكولونيالية وتشكُّلات الأيديولوجيا وأنماط الراوي وأنماط التجريب والتجديد، وغيرها من العناصر والتشكيلات السردية.
Bloqueio do plano transverso abdominal (TAP Block) com bupivacaína 0,25% realizado em bezerra submetida à herniorrafia umbilical- Relato de caso
Authors: Reina Isabela Marchesi , Freitas Igor Santos , Babboni Selene Daniela 
Published: October 2024

O Bloqueio do Plano Transverso Abdominal ou TAP Block surgiu na medicina humana em 2001 por Rafi e foi modificado em 2007 com a introdução do ultrassom na sua execução. Já na medicina veterinária, a técnica foi introduzida em 2010, feita inicialmente em um lince canadense. Em bezerros, seu uso foi descrito na literatura apenas em 2017, em duas herniorrafias umbilicais, onde se mostrou um método promissor. O TAP Block é uma técnica de anestesia locorregional, onde realiza-se a deposição de anestésicos locais no plano fascial entre os músculos transverso abdominal e oblíquo interno, visando anestesiar fibras aferentes dos nervos torácicos caudais e lombares craniais, que inervam a parede abdominal. Hoje em dia, tal técnica é utilizada em diversos procedimentos como mastectomia, laparotomias, nefrectomia, esplenectomia, herniorrafias, ressecção de tumores cutâneos, dentre outros, dado que adquirindo-a no protocolo anestésico, é capaz de diminuir as quantidades requeridas de anestésicos gerais e traz melhora significativa no pós-cirúrgico. Isto posto, objetivou-se relatar o uso do TAP Block com bupivacaína 0,25% em uma bezerra de 3 meses submetida à herniorrafia umbilical à campo. No protocolo anestésico empregado, utilizou-se 0,1 mg/kg de xilazina ne medicação pré-anestésica (MPA), bupivacaína 2 mg/kg diluída 0,25% com solução fisiológica (NaCl 0,9%) para o bloqueio do plano transverso do abdômen, cetamina 2 mg/kg para a indução e propofol ao efeito para a manutenção. O bloqueio foi realizado bilateralmente em decúbito lateral, de maneira rápida e segura. Durante o trans-cirúrgico, a bezerra foi monitorada quanto à frequência cardíaca (FC), frequência respiratória (FR), profundidade anestésica de acordo com Guedel, sendo mantida em plano cirúrgico superficial, e não apresentou intercorrências. No pós-cirúrgico houve a recuperação rápida do animal e ausência de sinais álgicos.
Correction of Functional Activity Disorders in Patients with Multiple Sclerosis
Authors: Ясинская Я.К. , Кузьминова Т.А. 
Published: October 2024

Рассеянный склероз – прогрессирующее аутоиммунное заболевание с разнообразием симптомов. Поскольку заболевание часто поражает людей молодого и трудоспособного возраста, оно является важной экономической и социальной проблемой. В зависимости от течения и степени нарушения функций пациент может иметь различные нарушения двигательных паттернов, отмечать разные степени проявления проблем. Для коррекции двигательных нарушений наибольшей эффективностью обладает физическая реабилитация, которая включает двигательное переобучение измененных двигательных паттернов, реорганизацию активностей, является эффективным методом сохранения трудоспособности и адаптации к бытовым функциям, учитывая двигательные возможности пациентов с рассеянным склерозом.
Multiple sclerosis is a progressive autoimmune disease with a variety of symptoms. Since the disease often affects people of young and working age, it is an important economic and social problem. Depending on the course and degree of dysfunction, the patient may have various disorders of motor patterns and note different degrees of manifestation of problems. Physical rehabilitation is most effective for the correction of motor disorders. Physical rehabilitation, which includes motor retraining of altered motor patterns, reorganization of activities, is an effective method of maintaining working capacity and adapting to everyday functions, considering their motor capabilities of patients with multiple sclerosis.
Medical Termination of Pregnancy and Clinical Criteria for the Acceptability of Rehabilitation Therapy
Authors: Можейко Л.Ф. 
Published: October 2024

Сложная демографическая ситуация, сопровождающая отрицательный прирост населения, ухудшающиеся с каждым годом показатели женского здоровья уменьшают репродуктивный потенциал белорусской нации. В связи с этим крайне важна информация о наиболее щадящих методах прерывания беременности по медицинским показаниям и при нежелательной беременности. Общеизвестно, что хирургические методы часто приводят к осложнениям и ухудше- нию здоровья молодых женщин. Именно по этой причине ведется активная научно- практическая работа, направленная на расширение показаний для медикаментоз- ного аборта как наиболее щадящего метода сохранения репродуктивного здоровья и фертильности в дальнейшем.
The difficult demographic situation that accompanies negative population growth and women’s health indicators worsening every year reduce the reproductive potential of the Belarusian nation. In this regard, information about the most gentle methods of abortion for medical reasons and in case of unwanted pregnancy is extremely important. It is well known that surgical methods often lead to complications and deterioration in the health of young women. It is for this reason that active scientific and practical work is being carried out aimed at expanding the indications for medical abortion, as the mostgentle method of preserving reproductive health and fertility in the future.
THE MUSEUM “KRASNOUFIMSKAYAZEMSKAYA BOLNITZA”. A MONUMENT OF ZEMSKIJ PERIOD OF THE RUSSIAN HISTORY OF MEDICINE
Authors: Артемьева А.И. , Стамикова Т.П. 
Published: October 2024

В статье рассмотрены события этапа становления Красноуфимской земской больницы и деятельность ее основателя – М.И. Мизерова.
The article deals with the events of the stage of formation of the Krasnoufimsky Zemsky hospital and the activities of its founder M.I. Mizerov.
FEATURES OF EVACUATION AND TREATMENT OF THE WOUNDED IN MOUNTAINS DURING THE BATTLE FOR THE CAUCASUS
Authors: Карташев А.В. 
Published: October 2024

Приводятся воспоминания защитников перевалов Кавказа о характере ран и заболеваний, о работе медицинского персонала в условиях высокогорной местности, о различных способах и средствах эвакуации раненых и обмороженных воинов Красной армии.
The recollections of the defenders of the Caucasus passes about the nature of wounds and diseases, about the work of medical personnel in high mountainous terrain, about various methods and means of evacuating wounded and frostbitten soldiers of the Red Army are presented.
MEDICINE AS A HEROIC DEED: “IMMORTAL REGIMENT OF CHITA STATE MEDICAL ACADEMY”
Authors: Губанова И.В. , Москалева Е.П. , Смекалов В.П. 
Published: October 2024

Статья посвящена истории создания «Бессмертного полка ЧГМА», его роли в гражданско-патриотическом воспитании студентов.
The article is devoted to the history of the Immortal Regiment of the ChSMA, its role in the civil and patriotic education of students.
PARENTAL SERVICE IN EASTERN SIBERIA AT THE BORDER OF THE 19-20 CENTURIES: FUNCTIONS, WORKING CONDITIONS, SOCIAL BENEFITS
Authors: Демидова Т.В. 
Published: October 2024

В статье показаны становление фельдшерской службы в Восточной Сибири, функциональные обязанности фельдшера, условия работы, дифференцированный подход к оплате труда, набор социальных льгот, открытие фельдшерских школ.
The article shows the formation of a paramedic service in Eastern Siberia, the functional duties of a paramedic, working conditions, a differentiated approach to remuneration, a set of social benefits, the opening of paramedic schools.
ORGANIZATION OF DENTAL CARE ON THE SHIPS OF THE RUSSIAN IMPERIAL FLEET
Authors: Мейлих И.М. , Ковалевский А.М. 
Published: October 2024

Статья посвящена организации первого в истории военной стоматологии штатного зубоврачебного кабинета на Русском Императорском Флоте.
The article is devoted to the organization of the first full-time dental office in the history of military dentistry in the Russian Imperial Fleet.
HEADS OF THE DENTAL POLYCLINIC OF THE KALININ MEDICAL INSTITUTE – PARTICIPANTS OF THE GREAT PATRIOTIC WAR
Authors: Теремов Д.Д. , Зобачева В.В. 
Published: October 2024

Статья представляет собой жизнеописания главных врачей стоматологической поликлиники Калининского государственного медицинского института (ныне Тверской государственный медицинский университет) – участников Великой Отечественной войны, сотрудников профильных кафедр стоматологического факультета КГМИ профессора Рафаила Дмитриевича Новосёлова и доцента Мстислава Николаевича Михайлова. В работе прослеживается боевой и трудовой путь ветеранов, дается оценка их вклада в развитие системы стоматологической помощи населению, а также освещается научная работа Р.Д. Новосёлова и М.Н. Михайлова.
The article presents the biographies of the chief doctors of the dental polyclinic of the Kalinin State Medical Institute (now Tver State Medical University) – participants of the Great Patriotic War, employees of the specialized departments of the Faculty of Dentistry of the KSMI Professor R.D. Novoselov and associate Professor M.N. Mikhailov. The work traces the combat and labor path of veterans, assesses their contribution to the development of the dental care system for the population, and also highlights the scientific work of R.D. Novoselov and M.N. Mikhailov.
FROM THE ZEMSTVO DISTRICT HOSPITAL TO THE STARY OSKOL CENTRAL DISTRICT HOSPITAL OF THE BELGOROD REGION
Authors: Кистенева О.А. , Белевич М.С. 
Published: October 2024

Статья посвящена истории становления и деятель- ности Старооскольской центральной районной больницы Белгород- ской области.
The article is devoted to the history of the formation and activities of the Stary Oskol Central District Hospital of the Belgorod Region.
NEW CONCEPTS OF PROFESSIONAL ETHICS OF MEDICAL WORKERS
Authors: Ибрагимова Э.И. , Горелова В.Г. , Гамзаева А.У. , Магомедова З.С. , Тавлуева С.С. 
Published: October 2024

В современной медицинской практике проявление высокой этики и профессионализма является неотъемлемой частью успешного взаимодействия с пациентами и обществом в целом. В связи с постоянными изменениями в сфере здравоохранения необходимо внедрять новые концепции профессиональной этики, которые соответствовали бы современным реалиям и потребностям пациентов. Одной из ключевых концепций, которая заслуживает особого внимания, является понятие пациентоориентированности в качестве основного принципа медицинской этики. Пациентоори- ентированная этика предполагает, что поведение и принятие реше- ний медицинских работников должно быть направлено на удовлет- ворение потребностей и ожиданий пациентов. Она предусматривает активное слушание, эмпатию и сотрудничество между врачами и пациентами, а также признание и уважение их прав на информа- цию, приватность и достоинство.
In modern medical practice the manifestation of high ethics and professionalism is an integral part of successful interaction with patients and society as a whole. Due to constant changes in healthcare, it is necessary to introduce new concepts of professional ethics that would correspond to modern realities and patients’ needs. One key concept that deserves special attention is the notion of patient-centredness as a basic principle of medical ethics. Patient-centred ethics suggests that the behaviour and decision-making of health professionals should be directed towards meeting the needs and expectations of patients. It involves active listening, empathy and co-operation between doctors and patients, as well as recognising and respecting their rights to information, privacy and dignity.
NO ONE IS FORGOTTEN, NOTHING IS FORGOTTEN
Authors:  Тюрина О.В. ,  Манукян К.А. 
Published: October 2024

Статья посвящена работе Ивановских эвакуацион- ных госпиталей в годы Великой Отечественной войны, а также дея- тельности музея истории городского округа Кохма по увековечива- нию подвига медицинского персонала.
The article is devoted to the work of the Ivanovo evacuation hospitals during the Great Patriotic War, as well as the activities of the Museum of History of the Kokhma Urban District to perpetuate the feat of medical personnel.
TEACHER, SURGEON, PIONEER, HEALTHCARE ORGANIZER, ACADEMICIAN, PROFESSOR NAIL GAYNATOVICH GATAULLIN
Authors:  Каримов М.А. ,  Киньябулатов А.У. 
Published: October 2024

К 95-летию со дня рождения академика АН РБ, профессора Наиля Гайнатовича Гатауллина, основные этапы его жизни и деятельности.
On the 95th anniversary of the birth of Academician of the Academy of Sciences of the Republic of Bashkortostan, Professor Nail Gaynatovich Gataullin, the main stages of his life and work.