bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resolving systematic errors in widely-used enhancer activity assays in human cells enables genome-wide functional enhancer characterization
Authors: Muerdter Felix , Boryń Łukasz M. , Woodfin Ashley R. , Neumayr Christoph , Rath Martina , Zabidi Muhammad A. , Pagani Michaela , Haberle Vanja , Kazmar Tomáš , Catarino Rui R. , Schernhuber Katharina , Arnold Cosmas D. , Stark Alexander 
Published: July 2017

AbstractThe identification of transcriptional enhancers in the human genome is a prime goal in biology. Enhancers are typically predicted via chromatin marks, yet their function is primarily assessed with plasmid-based reporter assays. Here, we show that two previous observations relating to plasmid-transfection into human cells render such assays unreliable: (1) the function of the bacterial plasmid origin-of-replication (ORI) as a conflicting core-promoter and (2) the activation of a type I interferon (IFN-I) response. These problems cause strongly confounding false-positives and -negatives in luciferase assays and genome-wide STARR-seq screens. We overcome both problems by directly employing the ORI as a core-promoter and by inhibiting two kinases central to IFN-I induction. This corrects luciferase assays and enables genome-wide STARR-seq screens in human cells. Comprehensive enhancer activity profiles in HeLa-S3 cells uncover strong enhancers, IFN-I-induced enhancers, and enhancers endogenously silenced at the chromatin level. Our findings apply to all episomal enhancer activity assays in mammalian cells, and are key to the characterization of human enhancers.
Estimating encounter rates as the first step of sexual selection in the lizardAnolis sagrei
Authors: Kamath Ambika , Losos Jonathan B. 
Published: July 2017

AbstractHow individuals move through their environment dictates which other individuals they encounter, determining their social and reproductive interactions and the extent to which they experience sexual selection. Specifically, females rarely have the option of mating with all males in a population—they can only choose among the males they encounter. Further, quantifying phenotypic differences between the males that females encounter and those that sire females’ offspring lends insight into how social and reproductive interactions shape male phenotypes. We used an explicitly spatiotemporal Markov chain model to estimate the number of potential mates ofAnolis sagreilizards from their movement behavior, and used genetic paternity assignments to quantify sexual selection on males. Females frequently encountered and mated with multiple males, offering ample opportunity for female mate choice. Sexual selection favored males that were bigger and moved over larger areas, though the effect of body size cannot be disentangled from last-male precedence. Our approach corroborates some patterns of sexual selection previously hypothesized in anoles based on describing them as territorial, whereas other results, including female multiple mating itself, are at odds with territorial polygyny, offering insight into discrepancies in other taxa between behavioral and genetic descriptions of mating systems.
The RacGAP βChimaerin is essential for cerebellar granule cell migration
Authors: Estep Jason A. , Wong Wenny , Wong Yiu-Cheung E. , Loui Brian M. , Riccomagno Martin M. 
Published: July 2017

AbstractDuring mammalian cerebellar development, postnatal granule cell progenitors proliferate in the outer part of the External Granule Layer (EGL). Postmitotic granule progenitors migrate tangentially in the inner EGL before switching to migrate radially inward, past the Purkinje cell layer, to achieve their final position in the mature Granule Cell Layer (GCL). Here, we show that the RacGAP β-chimaerin is expressed by a small population of late-born, premigratory granule cells. β-chimaerin deficiency causes a subset of granule cells to become arrested in the EGL, where they differentiate and form ectopic neuronal clusters. These clusters of granule cells are able to recruit aberrantly projecting mossy fibers. Collectively, these data suggest a role for β-chimaerin as an intracellular mediator of Cerebellar Granule Cell radial migration.
Work role transitions – expert nurses to novice preceptors
Authors: Miller Janice , Vivona Brian , Roth Gene 
Published: July 2017

PurposeSeveral issues are reported in the literature regarding the preparation and training of nurses for the preceptor role. The purpose of this study is to explore the experiences, growth and development of nurses transitioning to the preceptor role in allied health contexts.Design/methodology/approachA basic interpretive qualitative research method was used for this study. In total, 20 preceptors who were practicing in a variety of healthcare settings participated in in-depth interviews.FindingsThe preceptors of this study found meaning through their teaching and learning encounters with novice nurses. Their meaning making led to identity development and new perspectives on both the nursing and preceptor roles.Research limitations/implicationsThis study extends the literature on informal learning and training by focusing on the unique work role of nurse precepting. Conclusions of this study call for additional research that examines other occupational areas in which workers have transitioned from expert to novice again, and how training can enhance these transitionsPractical implicationsParticipants described several areas of improvement for preceptorships: additional administrative support, guidelines and standards for preceptor training and preparation and additional time and support for transitioning to the preceptor roleOriginality/valueWork role transition theory was used in this study to examine the preparation and training of preceptors. This study features the voices of nursing preceptors who have experienced changes in their employment status and major shifts in their work roles transitioning from expert to novice to expert again.
Developing entrepreneurial resilience: implications for human resource development
Authors: Lee Jin , Wang Jia 
Published: July 2017

PurposeLeadership development has attracted much research attention within the human resource development (HRD) community. However, little scholarly effort has been made to study a special group of leaders – entrepreneurs. This paper aims to fill in this knowledge gap by taking a close look at entrepreneurial resilience, a key ability of entrepreneurs to overcome challenges and adapt to uncertainties.Design/methodology/approachThis paper conducted an extensive literature review using conceptual analysis as the primary method. Enablers and inhibitors affecting entrepreneurial resilience development were identified from the selected empirical studies.FindingsFrom the analysis of empirical studies, a set of enablers and inhibitors was identified, and the effects on entrepreneur resilience were explored. Based on identified enablers and inhibitors, an integrative model of entrepreneurial resilience that serves as a building block for entrepreneurial resilience theory building was proposed.Originality/valueFindings from this research and the newly proposed model will not only contribute to the much-needed entrepreneurial resilience theory building but also serve as a useful guide for human resource professionals and trainers in designing leadership development interventions.
A review of policy, practices, and players governing and involved in the United States vaccine and immunization enterprise
Authors: Shen Angela K. , Tsai Alice Y. , Birkhead Guthrie S. 
Published: July 2017

PurposeThe purpose of this paper is to outline the organization and governance of the US vaccine and immunization enterprise. It describes the major components of the US system including the various relationships between major federal government entities, stakeholders, and advisory committees that inform government policymaking at various points in the system.Design/methodology/approachThe authors describe the complex interdependent network of partners that engage in a wide range of activities such as disease surveillance, research, vaccine development, regulatory licensure, practice recommendations, financing, service delivery, communications, and post-licensure monitoring.FindingsThe US system of governance is highly participatory and focuses on a transparent and open engagement, with input from a wide range of partners to inform decision-making. This collaborative framework allows many inputs to be heard and helps support the US vaccine and immunization system as it evolves to meet the continued public health needs in the USA through the optimal use of safe and effective vaccines.Originality/valueThis is an invited article on the US vaccine and immunization enterprise. The development and availability of vaccines in the USA has had profound impact on mortality and morbidity and public health (Centers for Disease Control and Prevention, 2011). The success of this enterprise is a result of a blended public and private sector system with partnerships at the federal, state, and local levels of government to optimize the use of safe and effective vaccines. Governance structures have been established to support the interaction and decision-making among the federal and non-federal actors toward the common goal of controlling and preventing infectious diseases.
Managing portfolio interdependencies
Authors: Killen Catherine P. 
Published: July 2017

PurposeThe purpose of this paper is to improve decision quality, and therefore project and portfolio success, by testing the influence of different visual representations of interdependency data in a simulated decision experiment. A network mapping approach to visualize project interdependencies is introduced and compared with matrix and tabular displays.Design/methodology/approachA simulated decision task in a controlled classroom setting tested five hypotheses though a sample of 480 experiments.FindingsThe type of data representation used is associated with differing levels of decision quality, and the use of network mapping displays is aligned with the best results.Research limitations/implicationsThe findings are limited as this experiment-based study presented a simplified decision scenario and involved students rather than practicing managers. The findings are best interpreted in combination with organization-based research.Practical implicationsThe findings of this study suggest that visual data displays, particularly network mapping displays, can provide benefits and improve project portfolio decision quality. Managers may draw upon this study to design ways to include visual data representations in their project portfolio management decision processes.Originality/valueThis study uses experimentation to complement organization-based studies to better understand the influence of different methods of visualizing data and managing interdependencies between projects. This research provides an important contribution to meet the acknowledged need for better tools to understand and manage project interdependencies.
Marketing by, for and of the project: project marketing by three types of organizations
Authors: Rodney Turner John , Lecoeuvre Laurence 
Published: July 2017

Purpose
The purpose of this paper is to place project marketing within the framework of organizational project management. There has been an ongoing discussion in the project marketing literature about whether project marketing is part of project management or project management is part of project marketing. Marketing is done by organizations to create a demand for products or services that have value for customers. The authors identify three types of organization involved in the management of projects, the project, the initiator and the contractor, and review current thinking on how they market their products and services, and create networks and dialogs to bring value to stakeholders.

Design/methodology/approach
The authors review the literature on project marketing, and develop new models based on an organizational perspective. The authors develop propositions as a basis for further research.

Findings
Marketing is done by three types of organization. The authors label these as marketing BY the project, marketing FOR the project by the contractor, and marketing OF the investment made by the project by the investor. The authors draw links with marketing theory, and introduce the service-dominant logic as a new perspective on organizational project marketing.

Research limitations/implications
Traditionally, project marketing theory has taken the perspective of the overlap between project management and project marketing. The authors take an organizational perspective, and identify avenues for research into how the types of organization involved in the management of projects create dialog with their customers and stakeholders to exchange products and services that have value for them.

Practical implications
Project managers have not traditionally viewed project marketing as having relevance to them. The authors show that providing a service to stakeholders is an essential part of the management of projects.

Originality/value
The authors develop directions for research into project marketing as part of organizational project management.
Suppliers’ software development project start-up practices
Authors: Merikoski Helena , Savolainen Paula , Ahonen Jarmo J. 
Published: July 2017

Purpose
The purpose of this paper is to present a life cycle phase of a software development project which is substantial for the success of the project. This paper visualizes the project start-up phase from suppliers’ perspective.

Design/methodology/approach
The method is a theory building from case studies. The data were collected from three software supplier firms by conducting process modeling separately in each firm.

Findings
The study resulted in a model of a supplier’s software project start-up which includes start-up practices and involved roles. The results indicate that project start-up is an integral and structured phase of project life cycle, which influences the execution of a software development project, especially from the supplier’s perspective in the project business context.

Research limitations/implications
The study focuses on the start-up phase of software development projects delivered to external customers. Therefore, developed project start-up model is applicable as such in software supplier firms.

Practical implications
The project start-up model presented in this paper indicates that project start-up is a complex and multi-dimensional activity in a supplier firm. This study suggests that if the project start-up phase is clearly defined, planned and followed in a supplier firm, it reduces confusion and miscommunication among the people involved in the project and helps to achieve the business goals of a project.

Originality/value
This study emphasizes that it is necessary to make a distinction between the perspectives of the customer and the supplier when studying projects in the project business context. The findings contribute the new knowledge for managing outsourced software development projects.
Stakeholder defined
Authors: McGrath Stephen Keith , Whitty Stephen Jonathan 
Published: July 2017

Purpose
The purpose of this paper is to create a “refined” (with unnecessary elements removed) definition of the term stakeholder, thereby removing confusion surrounding the use of this term from the general and project management arenas.

Design/methodology/approach
A method of deriving refined definitions for a group of terms by ensuring there are no unnecessary elements causing internal conflict or overlap is adopted and applied to resolve the confusion.

Findings
The refined definitions of stake and stakeholder are in terms of an interest and activity. This avoids all extensions of meaning introduced by defining particular types of stakeholders and/ or their degrees of impact. It also resolves the multiplicity of conflicting meanings possible when silent or assumed qualifiers of a word are ignored, restricting definition to, for example, project stakeholders or stakeholders of a firm. These definitions are carried forward into a mapping of the stakeholder locus of interest on an activity rather than a company base, enabling generic categorisation of stakeholders to be proposed for use in both private and public sectors. A governance difficulty with the term customer also emerged and a resolution to this is proposed.

Research limitations/implications
Resolution of the academic contention around the definition of stakeholders will facilitate future research endeavours by removing confusion surrounding the term. It can also provide clarity in governance arrangements in public and private sectors. Verification of the method used through its success in deriving this “refined” definition suggests its suitability for application to other contested terms.

Practical implications
Projects and businesses alike can benefit from removal of confusion around the definition of stakeholder in the academic research they fund and attempt to apply.

Social implications
A refined definition of the stakeholder concept will facilitate building social and physical systems and infrastructure, benefitting organisations, whether public, charitable or private.

Originality/value
Clarity results in the avoidance of confusion and misunderstanding together with their consequent waste of time, resources and money.
Interplay between performance measurement and management, employee engagement and performance
Authors: Smith Marisa , Bititci Umit Sezer 
Published: July 2017

PurposeThe purpose of this paper is to recognise the importance of the interplay between performance measurement, performance management, employee engagement and performance. However, the nature of this phenomenon is not well understood. Analysis of the literature reveals two dimensions of organisational control, technical and social, that are used to develop a conceptual framework for studying this phenomenon.Design/methodology/approachThe authors conducted explorative action research involving pilot and control groups from two departments of a UK bank.FindingsThe authors show that an intervention on the social controls has led to changes in technical controls of the performance measurement system resulting in significant improvement in employee engagement and performance.Research limitations/implicationsThe research was undertaken with two cases from a single organisation. Further fine-grained, longitudinal research is required to fully understand this phenomenon in a wider range of contexts.Practical implicationsThe paper contributes to the theory on performance measures and gives guidance on how organisations might design their performance measurement systems to enhance employee engagement and performance.Originality/valueThe study makes three contributions. First, the authors introduce a new theoretical framework based the organisational control theory providing a basis for future research. Second, through nine propositions, the authors establish a causal relationship between performance measurement, performance management, employee engagement and performance. Third, the authors identify a gap in knowledge concerning the design of organisational controls in the context of the process that is being managed.
Supply chain management and activity-based costing
Authors: Hofmann Erik , Bosshard Jan 
Published: July 2017

Purpose
The purpose of this paper is to summarize and analyze what is known regarding activity-based costing (ABC) applications in the context of supply chain management (SCM). The authors present a reference framework for practical implications and areas for future research in intra-firm and inter-organizational environments.

Design/methodology/approach
The findings underlie a systematic review methodology. Research gaps and guidance for further publications are derived from the reference framework based on ABC and SCM literature.

Findings
The review illustrates four main areas for further research: determination of the role of management accounting in SCM (including supply chain finance), integration of time-driven ABC with radio frequency identification (RFID) technology and automatic data collection, analysis of inter-organizational management tools in supply chains in multiple negotiation rounds, and standardization of cost accounting data in supply chains.

Practical implications
The review provides practitioners with three main recommendations: ABC applications require a solid data basis, organizational readiness, commitment from senior management, and an ABC management philosophy; open book accounting for inter-organizational cost information-sharing purposes needs institutional arrangements and economic incentive systems; and sharing costs and benefits among supply chain members requires a change of managers’ mind-set.

Originality/value
This paper reveals practical implications and provides new directions for research based on the reference framework. The paper contributes to the interdisciplinary topic between SCM and management accounting by providing a structured overview of 87 peer-reviewed articles from 1992 to 2016.
Education for sustainable development: an exploratory study in a Portuguese University
Authors: Torres Ricardo , Vieira Rui Marques , Rodrigues Ana V. , Sá Patrícia , Moreira Gillian 
Published: July 2017

Purpose
The research aims to evaluate whether this educational approach is being implemented in a Portuguese public university and looking for explicit references to education for sustainable development (ESD) in the online descriptions of course units (CU).

Design/methodology/approach
The research design adopted for this qualitative research follows the principles of a case study with exploratory, multiple and collective features.

Findings
It was possible to find direct matches with key ESD expressions in fifteen of CU. In addition, nine CU were identified in the second stage of analysis of the teacher training master programmes.

Research limitations/implications
One of the limitations of this study which the authors identified, and which was responsible for considerably reducing the probability of finding matches, was that only results in which the key expressions appeared in the description of the CU in exactly the same form as in the research instrument were recorded.

Practical implications
The need for an educational programme for teachers to be developed and implemented in the near future.

Social implications
A training workshop will be proposed with the main aim of supporting teaching staff in making the necessary shift in their pedagogical practices to include a ESD orientation in their CU.

Originality/value
The instrument eveloped that appears in Appendix - Analysis Tool with key ESD expressions.