bluuebunny/crossref_metadata_2025_split huggingface dataset:
Draft genome sequences of three fungal-interactive Paraburkholderia terrae strains, BS007, BS110 and BS437
Authors: Pratama Akbar Adjie , Haq Irshad Ul , Nazir Rashid , Chaib De Mares Maryam , van Elsas Jan Dirk 
Published: December 2017

AbstractHere, we report the draft genome sequences of three fungal-interactive
Paraburkholderia terrae
strains, denoted BS110, BS007 and BS437. Phylogenetic analyses showed that the three strains belong to clade II of the genus
Burkholderia
, which was recently renamed
Paraburkholderia
. This novel genus primarily contains environmental species, encompassing non-pathogenic plant- as well as fungal-interactive species. The genome of strain BS007 consists of 11,025,273 bp, whereas those of strains BS110 and BS437 have 11,178,081 and 11,303,071 bp, respectively. Analyses of the three annotated genomes revealed the presence of (1) a large suite of substrate capture systems, and (2) a suite of genetic systems required for adaptation to microenvironments in soil and the mycosphere. Thus, genes encoding traits that potentially confer fungal interactivity were found, such as type 4 pili, type 1, 2, 3, 4 and 6 secretion systems, and biofilm formation (PGA, alginate and pel) and glycerol uptake systems. Furthermore, the three genomes also revealed the presence of a highly conserved five-gene cluster that had previously been shown to be upregulated upon contact with fungal hyphae. Moreover, a considerable number of prophage-like and CRISPR spacer sequences was found, next to genetic systems responsible for secondary metabolite production. Overall, the three
P. terrae
strains possess the genetic repertoire necessary for adaptation to diverse soil niches, including those influenced by soil fungi.
Phase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors
Authors: Thomas Anish , Redon Christophe E. , Sciuto Linda , Padiernos Emerson , Ji Jiuping , Lee Min-Jung , Yuno Akira , Lee Sunmin , Zhang Yiping , Tran Lan , Yutzy William , Rajan Arun , Guha Udayan , Chen Haobin , Hassan Raffit , Alewine Christine C. , Szabo Eva , Bates Susan E. , Kinders Robert J. , Steinberg Seth M. , Doroshow James H. , Aladjem Mirit I. , Trepel Jane B. , Pommier Yves 
Published: December 2017

Purpose Our preclinical work identified depletion of ATR as a top candidate for topoisomerase 1 (TOP1) inhibitor synthetic lethality and showed that ATR inhibition sensitizes tumors to TOP1 inhibitors. We hypothesized that a combination of selective ATR inhibitor M6620 (previously VX-970) and topotecan, a selective TOP1 inhibitor, would be tolerable and active, particularly in tumors with high replicative stress. Patients and Methods This phase I study tested the combination of M6620 and topotecan in 3-week cycles using 3 + 3 dose escalation. The primary end point was the identification of the maximum tolerated dose of the combination. Efficacy and pharmacodynamics were secondary end points. Results Between September 2016 and February 2017, 21 patients enrolled. The combination was well tolerated, which allowed for dose escalation to the highest planned dose level (topotecan 1.25 mg/m2, days 1 to 5; M6620 210 mg/m2, days 2 and 5). One of six patients at this dose level experienced grade 4 thrombocytopenia that required transfusion, a dose-limiting toxicity. Most common treatment-related grade 3 or 4 toxicities were anemia, leukopenia, and neutropenia (19% each); lymphopenia (14%); and thrombocytopenia (10%). Two partial responses (≥ 18 months, ≥ 7 months) and seven stable disease responses ≥ 3 months (median, 9 months; range, 3 to 12 months) were seen. Three of five patients with small-cell lung cancer, all of whom had platinum-refractory disease, had a partial response or prolonged stable disease (10, ≥ 6, and ≥ 7 months). Pharmacodynamic studies showed preliminary evidence of ATR inhibition and enhanced DNA double-stranded breaks in response to the combination. Conclusion To our knowledge, this report is the first of an ATR inhibitor-chemotherapy combination. The maximum dose of topotecan plus M6620 is tolerable. The combination seems particularly active in platinum-refractory small-cell lung cancer, which tends not to respond to topotecan alone. Phase II studies with biomarker evaluation are ongoing.
Solid-State Esterification via Ionic-to-Covalent Bond Transformation in Ionic Molecular Crystals Consisting of Disubstituted Anthracene Anion-Cation Combinations
Authors: Suzuki Masato , Fujii Takahiro , Naito Yoko , Yamoto Kazuhisa , Matsuoka Shin-ichi , Takagi Koji , Sugiyama Haruki , Uekusa Hidehiro 
Published: December 2017

Abstract
Thermal solid-state reactions involving ionic-to-covalent bond transformation were achieved in the ionic molecular crystals of 1,8-bis[(pyridin-1-ium-1-yl)methyl]anthracene anthracene-1,8-dicarboxylate to produce the cyclic diester. The crystal structure given by X-ray diffraction analysis showed that the electrostatic interaction between the benzyl pyridinium cation and the carboxylate anion successfully works to locate these reaction sites close to each other and that there are channels for crystalline solvents and the liberated pyridine to escape. Thereby, the cyclic diester was selectively formed by the crystal-to-crystal reaction, which was proven by powder XRD profiles and optical microscopic and SEM images of the crystals before and after the reaction. This is the first thermal crystal-to-crystal condensation reaction. Another ionic molecular crystal of 1,8-bis[(pyridin-1-ium-1-yl)methyl]anthracene anthraquinone-1,8-dicarboxylate was also studied. Therein, the corresponding cyclic diester was also obtained, but the crystals were transformed to amorphous solid by the reaction.
A hidden burden of neonatal illness? A cross-sectional study of all admissions aged less than one month across twelve Kenyan County hospitals
Authors: Murphy Georgina A.V. , Nyakangi Vivian N. , Gathara David , Ogero Morris , English Mike ,   Clinical Information Network
Published: December 2017

Background: Small and sick newborns need high quality specialised care within health facilities to address persistently high neonatal mortality in low-income settings, including Kenya. Methods: We examined neonatal admissions in 12 public-sector County (formerly District) hospitals in Kenya between November 2014 and November 2016. Using data abstracted from newborn unit (NBU) admission registers and paediatric ward (PW) medical records, we explore the magnitude and distribution of admissions. In addition, interviews with senior staff were conducted to understand admission policies for newborns in these facilities. Results: Of the total 80,666 paediatric admissions, 28,884 (35.8%) were aged ≤28 days old. 24,212 (83.8%) of newborns were admitted to organisationally distinct NBU and 4,672 (16.2%) to general PW, though the proportion admitted to NBUs varied substantially (range 59.9-99.0%) across hospitals, reflecting widely varying infrastructure and policies. Neonatal mortality was high in NBU (12%) and PW (11%), though varied widely across facilities, with documentation of outcomes poor for the NBU. Conclusion: Improving quality of care on NBUs would affect almost a third of paediatric admissions in Kenya. However, comprehensive policies and strategies are needed to ensure sick newborns on general PWs also receive appropriate care.
Zinc and copper concentration do not differentiate bipolar disorder from major depressive disorder
Authors: Styczeń Krzysztof , Sowa-Kućma Magdalena , Dudek Dominika , Siwek Marcin , Reczyński Witold , Szewczyk Bernadeta , Misztak Paulina , Topór-Mądry Roman , Opoka Włodzimierz , Nowak Gabriel 
Published: December 2017

Cel pracyCelem niniejszej pracy było porównanie stężeń mikroelementów, cynku i miedzi w grupie pacjentów z rozpoznaniem choroby afektywnej dwubiegunowej (bipolar disorder – BD) i jednobiegunowej (major depressive disorder – MDD).MetodaDo badania zakwalifikowano 110 pacjentów z rozpoznaniem choroby afektywnej dwubiegunowej oraz 114 pacentów z rozpoznaniem choroby afektywnej jednobiegunowej. W celu przeprowadzenia oceny stężeń mikroelementów pomiędzy chorobą afektywną dwubiegunową i jednobiegunową wykorzystano metodę płomieniowej atomowej spektrometrii absorpcyjnej (flame atomic absorption spectrometry - FAAS) w przypadku cynku, natomiast metodę elektrotermicznej atomowej spektrometrii absorpcyjnej (electrothermal atomic absorption spectrometry - ET AAS) w przypadku miedzi.WynikiStężenia miedzi i cynku w grupie pacjentów z chorobą afektywną dwubiegunową i jednobiegunową zarówno w fazie remisji jak i depresji nie różniły się. Uwzględnienie w porównaniach typu I i II jak i fazy wczesnej i później choroby afektywnej dwubiegunowej z jednobiegunowej również nie wykazało żadnych różnic istotnych statystycznie.WnioskiBrak różnic w stężeniu cynku i miedzi pomiędzy pacjentami z rozpoznaniem choroby afektywnej dwubiegunowej i jednobiegunowej może wskazywać na wspólną etiologię tych zaburzeń.
Tooth wear and occlusal ageing
Authors: Murchie Bryan Daniel 
Published: December 2017

Occlusal changes occur slowly throughout each person's lifetime via the process of physiological tooth wear (TW). Importantly, once the occlusal scheme has been irreversibly changed beyond a certain point, then a chain reaction of restoration failures may commence. The trigger varies for each individual and it cannot always be predicted when, where or if this occurrence will take place. Importantly, when the patient attends with failing or failed dental treatment, particularly following repeated attempts to resolve it, then a detailed investigation of the occlusion must precede treatment. Any immediate repair or replacement without consideration of the underlying aetiology would simply suffer the same consequences. CPD/Clinical Relevance: Understanding the impact of occlusal changes on the overall survival of restorations and the health of the remaining dentition can help in early diagnoses, prevention and treatment.
eHealth in Wound Care: from conception to implementation
Authors: Moore Zena , Angel Donna , Bjerregaard Julie , O'Connor Tom , McGuiness William , Kröger Knut , Rasmussen Benjamin Schnack Brandt , Yderstrœde Knud Bonnet 
Published: December 2017

Executive summary Purpose This document aims to provide wound care clinicians with a rapid and structured overview of the key issues related to use of eHealth applications (telemedicine and telehealth) within wound care. This includes: An overview of terminology and available literature Guidance on the methodology for evaluation of eHealth solutions An introduction to and discussion of the potential benefits of eHealth technologies in wound care, and the possible barriers to their implementation Recommendations for ensuring a good implementation process and supporting involvement of wound care professionals in safeguarding that eHealth solutions meet the needs of the patients. Methodology The document sections lean on the structure and focus areas of the Model for ASsessment of Telemedicine (MAST) which defines crucial items to evaluate an eHealth application. The content of the document is developed on the basis of a literature review, identifying available documentation for use of eHealth solutions in wound care. Furthermore, it draws on various key documents recently published on the general development, evaluation and implementation of eHealth solutions. These include valuable up-to-date information relevant for any group of clinicians wishing to follow and influence the way eHealth solutions are integrated into clinical practice. Findings and conclusions The literature review revealed that the amount and level of evidence for use of eHealth applications in wound care is still limited. Some MAST domains are not examined in any of the available studies. Thus, more research is required to identify the potential benefits and harms to patients, and the possible challenges related to implementation of eHealth solutions in wound care. Potential barriers and facilitators for the implementation of eHealth applications into wound care practice are identified in the document, and these may all either enhance or impede the process. However, the available research does demonstrate patient satisfaction, improved access to health services for all client cohorts, and increased job satisfaction for clinicians. The document recommends that wound management clinicians, considering the use of eHealth applications in their clinical practice, consult widely and conduct regular evaluation of the outcomes to ensure efficient implementation of these services. To support this approach, steps to ensure a good implementation process within a given organisation have been proposed. These are synthesised into a three circle model.
HUMANO, PÓS-HUMANO E TRANSUMANO: FRONTEIRAS DÚBIAS E INDEFINIDAS NUM MUNDO DESIGUAL
Authors: Machadinha Maia João Jerónimo 
Published: December 2017

O debate comparativo entre os conceitos de humano, pós-humano e transumano tem vindo a realizar-se no meio académico e científico em face dos desenvolvimentos da ciência e da tecnologia. O próprio conceito de humanismo, na visão europeísta, sempre comportou teologismos que ambicionaram a transcendência das capacidades humanas. Este artigo pretende evidenciar a dificuldade da delimitação destes conceitos devido à relação entre a evolução humana e o desenvolvimento da técnica. No entanto, perante as dinâmicas de globalização do atual sistema mundial também se demonstra a iminência de se originarem fraturas entre as populações humanas atuais.
Análisis de los hábitos de la población como herramienta para la planificación de los espacios verdes públicos
Authors: Gómez Piovano Dra. Arq. Jimena , Mesa Dr. Arq. Alejandro 
Published: December 2017

En las ciudades actuales la presencia o no de espacios públicos de recreación (parques, plazas, espacios verdes y ramblas) influye en la calidad de vida de los habitantes y en consecuencia, en los niveles de sostenibilidad de la misma. Existen numerosos estudios que describen los beneficios que los mismos producen a nivel social, económico y ambiental, a la vez que refieren lo favorable que es su uso, en la salud de los habitantes. A pesar de lo extenso de la bibliografía existente no se halla unanimidad en relación a los radios de influencia de los distintos tipos de espacios públicos de recreación. Por ello, este estudio tiene como objetivo analizar y comprender los hábitos de la población de Área Metropolitana de Mendoza y así determinar si la ciudad posee la suficiente cantidad de superficie verde y si su disposición en la trama satisface a las necesidades de todos sus habitantes.
BENEFÍCIOS DECORRENTES DE PRÁTICA DO CUIDADO FARMACÊUTICO EM HIPERTENSÃO E DIABETES TIPO 2 PARA SUA EFETIVAÇÃO EM UNIDADES DE SAÚDE
Authors: Nicoletti Maria Aparecida , Kubota Lina Terumi 
Published: December 2017

Pacientes portadores de doenças crônicas, em especial, hipertensão e diabetes, necessitam acompanhamento constante do profissional da saúde, pois o descontrole tanto da glicemia como da pressão arterial é precursora de crises fatais do funcionamento de rins, problemas cardiovasculares e motores, gerando custos evitáveis ao sistema público de saúde. O objetivo desse trabalho é buscar evidências que demonstrem os benefícios dos cuidados farmacêuticos a pacientes portadores de doenças crônicas não transmissíveis, em especial, hipertensão e diabetes tipo 2, por meio A pesquisa é uma revisão narrativa utilizando busca de artigos nas bases científicas de dados Web of Science, SciELO, Biblioteca Virtual em Saúde, Bancos de Dados Bibliográficos da USP (DEDALUS) e PubMed-NCBI, bem como dados epidemiológicos do DATASUS e diretrizes brasileiras, para a contextualização de hipertensão e diabetes. Foi observado que a prática de cuidados farmacêuticos impactou no índice de adesão ao tratamento em pacientes hipertensos e/ou diabéticos, proporcionando melhora clínica e na qualidade de vida gerando, ainda, um benefício socioeconômico. ɠimportante enfatizar que o cuidado farmacêutico não é praticado isoladamente de outros serviços de saúde, mas em colaboração com os pacientes e a equipe multidisciplinar em saúde; cada profissional deve atuar em seu âmbito de competência, o que resultará em benefício ao paciente e ao setor público.
TRIAGEM ANTIMICROBIANA DE EXTRATOS METANÓLICOS OBTIDOS DE PLANTAS FRUTÍFERAS SELECIONADAS DA FLORA CATARINENSE, BRASIL
Authors: Nesello Luciane Angela Nottar , Campos Adriana , Schinkel Gabriel Reis , Bella Cruz Alexandre , Cechinel Filho Valdir 
Published: December 2017

Devido à crescente dificuldade de combater microrganismos resistentes a antimicrobianos, o potencial antimicrobiano de algumas plantas tem despertado o interesse de pesquisadores por serem uma alternativa natural, e pelas potencialidades consagradas. O presente estudo teve por objetivo realizar triagem do potencial antimicrobiano, contra microrganismos patogênicos aos seres humanos, de extratos de plantas frutíferas silvestres por meio da determinação da concentração inibitória mínima (CIM). As plantas foram selecionadas pela indicação de uso popular e domesticação na região do Vale do Itajaí e seus extratos metanólicos foram submetidos à análise fitoquímica por cromatografiaem camada delgada usando reveladores específicos. O extrato da polpa madura de Marlierea tomentosa apresentou excelente atividade antimicrobiana contra a bactéria Staphyllococcus aureus e o extrato das sementes de Plinia edulis mostrou boa atividade. Os extratos das sementes de Eugenia brasiliensis, galhos de M. tomentosa e sementes de Myrcianthes pungens foram considerados moderadamente ativos. Pode ser concluido que há potencial antimicrobiano em alguns extratos estudados, porém ensaios complementares se fazem necessários com diferentes linhagens bacterianas, com o intuito de assegurar e complementar os resultados apresentados, além de isolar e identificar os respectivos princípios ativos.
INDICADORES DE QUALIDADE EM INDÚSTRIA FARMACÊUTICA
Authors: Nunes Pinheiro Ana Débora 
Published: December 2017

A qualidade de processos industriais farmacêuticos e como obtê-la é um tema de grande interesse na indústria farmacêutica, principalmente no que diz respeito a sua padronização. Com a normatização dos guias de boas práticas farmacêuticas e a padronização das práticas, passou a ocorrer uma maior preocupação, inclusive governamental, com o que seria qualidade e como alcançá-la. O objetivo deste trabalho foi reunir os principais guias de referência e as práticas utilizadas como indicadores de qualidade na indústria farmacêutica. Para tanto, foram selecionados 21 trabalhos obtidos por meio de pesquisa em bancos de dados disponíveis online, além de guias de referência de organizações internacionais, como Organização Mundial da Saúde (OMS), Food and Drug Administration (FDA) e International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH). Após a organização e a leitura do material selecionado, foram descritas algumas práticas de qualidade atualmente utilizadas na indústria farmacêutica: gestão de risco, quality by design, ações corretivas e preventivas, lean manufacturing, sistema de qualidade total e séries ISO. Apesar de existir uma regulamentação bastante completa e atual acerca de indicadorese práticas de qualidade em indústria farmacêutica, as publicações não relatam informações específicas e experiências práticas da implementação desses sistemas de qualidade, dificultando assim, exemplificar melhor como essas estratégias influenciam positivamente no gerenciamento das indústrias farmacêuticas.
EVALUATION OF QUALITY ATTRIBUTES OF PROPRANOLOL SPLIT TABLETS: FOCUS ON DOSE VARIABILITY
Authors: Eserian Jaqueline Kalleian , Lombardo Márcia 
Published: December 2017

Tablet splitting is a widespread practice among patients and health professionals aiming the administration of lower doses and the reduction of the cost of prescriptions. Nevertheless, potential concerns such as weight variation, stability and uneven drug content of the halves are related to this practice. The objective of this study was to evaluatethe uniformity of half-tablets regarding weight and drug content in three different commercial products containing propranolol. Also, it was assessed drug content for whole tablets. Weight variation and drug content uniformity tests were evaluated for whole and split tablets, as well as the weight loss due to the splitting process. Drug contentevaluation for whole tablets showed that all products were satisfactory. All the products were approved in the weight variation and drug content uniformity tests before splitting, with results close to 100%, but the halves of all products failed the tests, presenting a high variability between the portions. In one of the products, halves ranged from 75.5to 120.4% of the target drug content, indicating that when administered to patients, daily doses may vary around 45%. Splitting propranolol tablets might compromise clinical treatment, affecting blood pressure and consequently producing side effects. Clinical implications due to tablet splitting might not be critical in some cases. Nevertheless, the high variability between doses should be considered by healthcare professionals when prescribing a therapy involving this practice.
The typological debates around Le Jeu de la Hache (BnF MS Français 1996) and their stakes for HEMA practice
Authors: Le Coultre Anne-Caroline 
Published: December 2017

Abstract
Le Jeu de la Hache displays a fighting-system with the pollaxe in armour, but the weapon is never described with precision, which leads to debates regarding its typology – cutting edge or hammer/raven’s beak? Through a semi-quantitative survey, we tried to offer an overview of current HEMA practice around this specific source, with special emphasis on the typological question. Despite the rather narrow scope of the inquiry, some trends emerge. Besides the various choices regarding terminology and sources, we can underline the variety of materials used for the simulators: rubber components («hammer» typology) are leading, but wood and metal are also used, for both typologies. Advantages and disadvantages of each rely on the articulation of safety and realism dimensions, and the dangerousness inherent to this kind of weapon is largely highlighted. Even if most respondents declare not to be familiar with the typological debates amongst historians, it was usually mentioned to them during their practice. Only a minority has taken part in experiments in order to bring some elements of answer, but seldom in a systematic way. Therefore, a praxeological experimental approach could bring up new data, but is not devoid of difficulties, for instance the necessity of wearing armour.
A Mathematical Model for End-Product Toxicity
Authors: Ian Nelson Mark 
Published: December 2017

Abstract
Alcohol based biofuels, such as bio-butanol, have considerable potential to reduce the demand for petrochemical fuels. However, one of the main obstacles to the commercial development of biological based production processes of biofuels is end-product toxicity to the biocatalyst. We investigate the effect of end-product toxicity upon the steady-state production of a biofuel produced through the growth of microorganisms in a continuous flow bioreactor. The novelty of the model formulation is that the product is assumed to be toxic to the biomass. The increase in the per-capita decay rate due to the presence of the product is assumed to be proportional to the the concentration of the product. The steady-state solutions for the model are obtained, and their stability determined as a function of the residence time. These solutions are used to investigate how the maximum yield and the reactor productivity depend upon system parameters. Unlike systems which do not exhibit toxicity there is a value of the feed concentration which maximises the product yield. The maximum reactor productivity is shown to be a sharply decreasing function of both the feed concentration and the toxicity parameter. In conclusion, alternative reactor configurations are required to reduce the effects of highly toxic products.