bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobilising intellectual capital to improve European universities’ competitiveness
Authors: Secundo Giustina , De Beer Christle , Schutte Cornelius S.L. , Passiante Giuseppina 
Published: May 2017

Purpose
Universities concerned with third mission activities are engines that increase regional competitiveness since their primary role in the knowledge-based economy is to stimulate innovation by transferring new knowledge and technologies to industry and society. The purpose of this paper is to show how IC can be mobilized by university technology transfer offices (TTOs) due to the correlation between efficient university technology transfer and intellectual capital (IC), thus contributing to the third stage of IC research.

Design/methodology/approach
The application of the Maturity Model developed by Secundo et al. (2016) is expanded by collecting data from 18 universities in the European countries to illustrate how IC can be used as a strategy and solution to the barriers faced by TTOs.

Findings
TTOs with increased access to and utilization of IC tend to have higher maturity levels. This new application of the Maturity Model, proves that IC can be utilized to manage and improve the efficiency of TTOs.

Research limitations/implications
An indication of the level of access that TTOs have to university IC is given leading to recommendations to improve university technology transfer. Future research should include a wider sample of universities to increase the validation of the Maturity Model and to prove it as a suitable and strategic approach for IC management at TTOs.

Practical implications
Knowing which IC components are essential for the efficiency of TTOs, and which IC needs greater utilization, will provide insights into policy and practical interventions to improve their efficiency, resulting in increasing universities’ competitiveness.

Originality/value
A new approach and perspective on utilizing IC to improve university technology transfer to contribute to the third stage of IC research calling for more practice-oriented research.
Personality disorder service provision: a review of the recent literature
Authors: Evans Sacha , Sethi Faisil , Dale Oliver , Stanton Clive , Sedgwick Rosemary , Doran Monica , Shoolbred Lucinda , Goldsack Steve , Haigh Rex 
Published: May 2017

PurposeThe purpose of this paper is to describe the evolution of the field of personality disorder since the publication of “Personality disorder: no longer a diagnosis of exclusion” in 2003.Design/methodology/approachA review of both the academic literature contained within relevant databases alongside manual searches of policy literature and guidance from the key stakeholders was undertaken.FindingsThe academic and policy literature concentrates on treating borderline and antisocial personality disorders. It seems unlikely that evidence will resolutely support any one treatment modality over another. Criticism has arisen that comparison between modalities misses inter and intra patient heterogeneity and the measurement of intervention has become conflated with overall service design and the need for robust care pathways. Apparent inconsistency in service availability remains, despite a wealth of evidence demonstrating the availability of cost-effective interventions and the significant inequality of social and health outcomes for this population.Research limitations/implicationsThe inclusion of heterogeneous sources required pragmatic compromises in methodological rigour.Originality/valueThis paper charts the recent developments in the field with a wealth of wide-ranging evidence and robust guidance from institutions such as NICE. The policy literature has supported the findings of this evidence but current clinical practice and what patients and carers can expect from services remains at odds. This paper lays bare the disparity between what we know and what is being delivered. The authors argue for the need for greater research into current practice to inform the setting of minimum standards for the treatment of personality disorder.
Psychometric properties of the WHOQOL-BREF amongst wounded, injured, and ill members of the United States military
Authors: Lindsay Keston , Ferrer Michelle , Davis Ronald , Nichols David 
Published: May 2017

Purpose
Advances in military medical care have facilitated a reduction of fatalities in the global war on terror, relative to previous conflicts. The physical and psychological trauma of returning personnel remain a challenge, and poor physical and psychological health have been shown to affect quality of life (QOL). The purpose of this paper is to validate the WHOQOL-BREF questionnaire amongst wounded, injured and ill military personnel, and to determine the characteristics of distinct groups found in this sample.

Design/methodology/approach
In total, 52 male and female military personnel (34.69+7.63 years, n=51) completed 24 items of the WHOQOL-BREF. Principal component analysis using the direct oblimin rotation was used to determine the factor structure of the WHOQOL-BREF and k-means cluster analysis was used to determine QOL characteristics of the separate groups.

Findings
The WHOQOL-BREF is a reliable tool for measuring QOL for American military personnel. However, the psychometric structure of the WHOQOL-BREF in this sample differed from the original domains. The first cluster analysis based on the original domains produced two clusters: a group of 12 that had poor QOL, and a group of 40 that had relatively good QOL except for the physical domain. The second cluster analysis differed in independence and access/social support only.

Research limitations/implications
Although the sample was small for principal component analysis, the investigators chose to proceed with this procedure, because objective indicators such as measures of sampling adequacy and communalities met or exceeded acceptable thresholds.

Originality/value
Rehabilitation programs for military ill, injured and wounded should contain components that promote independence and self-actualization.
Dermoscopic features of digital mucous cysts: A study of 23 cases
Authors: Chae Je Byeong , Ohn Jungyoon , Mun Je‐Ho 
Published: May 2017

AbstractDigital mucous cysts (DMC) are common benign myxoid cysts typically located on the fingers and toes. Recently, dermoscopic patterns of DMC were reported. However, only a small number of cases were described in the published work; therefore, information on this topic is scarce in the published work. We investigated dermoscopic patterns of histopathologically diagnosed DMC. In total, 23 cases were enrolled in this study. Polarized dermoscopy revealed vascular patterns in 13 cases (56.5%), with arborizing vascular patterns, dotted vessels, linear vessels and polymorphous vessels in eight (34.8%), three (13.0%), one (4.3%) and one (4.3%) case, respectively. Red‐purple lacunas, ulceration, nail dystrophy and white shiny structures were detected in five (21.7%), two (8.7%), seven (30.4%) and six cases (26.1%), respectively. We report the largest case series regarding dermoscopic features of DMC to date. Dermoscopy can be used as a helpful adjuvant and non‐invasive tool in the diagnosis of DMC.
Unveiling microbial interactions in stratified mat communities from a warm saline shallow pond
Authors: Saghaï Aurélien , Gutiérrez‐Preciado Ana , Deschamps Philippe , Moreira David , Bertolino Paola , Ragon Marie , López‐García Purificación 
Published: May 2017

SummaryModern phototrophic microbial mats are complex communities often used as analogs of major Precambrian ecosystems. Characterizing biotic, notably metabolic, interactions among different microbial mat members is essential to gain insights into the ecology and biogeochemistry of these systems. We applied 16S/18S rRNA metabarcoding approaches to characterize the structure of archaea, bacteria and protist communities from microbial mats collected along strong physicochemical (oxygen, salinity, temperature, depth) gradients in a shallow pond at the salar de Llamara (Chile). All mats were highly diverse, including members of virtually all known high‐rank eukaryotic and prokaryotic taxa but also many novel lineages. Bacterial candidate divisions accounted for almost 50% of sequences in deeper mats, while Archaea represented up to 40% of sequences in some mat layers. Molecular phylogenetic analyses revealed six novel deeply divergent archaeal groups, along abundant and diverse Pacearchaeota and Woesearchaeota. Multivariate statistical analyses showed that local environmental conditions strongly influenced community composition. Co‐occurrence network structure was markedly different between surface mats located in the oxygenated zone and mats located in transition and anoxic water layers. We identified potential biotic interactions between various high‐ and low‐rank taxa. Notably, a strong positive correlation was observed between Lokiarchaeota and the poorly known candidate bacterial division TA06.
Functional structure of the bromeliad tank microbiome is strongly shaped by local geochemical conditions
Authors: Louca Stilianos , Jacques Saulo M. S. , Pires Aliny P. F. , Leal Juliana S. , González Angélica L. , Doebeli Michael , Farjalla Vinicius F. 
Published: May 2017

SummaryPhytotelmata in tank‐forming Bromeliaceae plants are regarded as potential miniature models for aquatic ecology, but detailed investigations of their microbial communities are rare. Hence, the biogeochemistry in bromeliad tanks remains poorly understood. Here we investigate the structure of bacterial and archaeal communities inhabiting the detritus within the tanks of two bromeliad species, Aechmea nudicaulis and Neoregelia cruenta, from a Brazilian sand dune forest. We used metagenomic sequencing for functional community profiling and 16S sequencing for taxonomic profiling. We estimated the correlation between functional groups and various environmental variables, and compared communities between bromeliad species. In all bromeliads, microbial communities spanned a metabolic network adapted to oxygen‐limited conditions, including all denitrification steps, ammonification, sulfate respiration, methanogenesis, reductive acetogenesis and anoxygenic phototrophy. Overall,
reducers dominated in abundance over sulfate reducers, and anoxygenic phototrophs largely outnumbered oxygenic photoautotrophs. Functional community structure correlated strongly with environmental variables, between and within a single bromeliad species. Methanogens and reductive acetogens correlated with detrital volume and canopy coverage, and exhibited higher relative abundances in N. cruenta. A comparison of bromeliads to freshwater lake sediments and soil from around the world, revealed stark differences in terms of taxonomic as well as functional microbial community structure.
Membrane vesicle secretion and prophage induction in multidrug‐resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress
Authors: Devos Simon , Van Putte Wouter , Vitse Jolien , Van Driessche Gonzalez , Stremersch Stephan , Van Den Broek Wim , Raemdonck Koen , Braeckmans Kevin , Stahlberg Henning , Kudryashev Misha , Savvides Savvas N. , Devreese Bart 
Published: May 2017

SummarySeveral bacterial species produce membrane vesicles (MVs) in response to antibiotic stress. However, the biogenesis and role of MVs in bacterial antibiotic resistance mechanisms have remained unclear. Here, we studied the effect of the fluoroquinolone ciprofloxacin on MV secretion by Stenotrophomonas maltophilia using a combination of electron microscopy and proteomic approaches. We found that in addition to the classical outer membrane vesicles (OMV), ciprofloxacin‐stimulated cultures produced larger vesicles containing both outer and inner membranes termed outer‐inner membrane vesicles (OIMV), and that such MVs are enriched with cytosolic proteins. Remarkably, OIMV were found to be decorated with filamentous structures identified as fimbriae. In addition, ciprofloxacin stress leads to the release of bacteriophages and phage tail‐like particles. Prophage induction by ciprofloxacin has been linked to pathogenesis and horizontal gene transfer in several bacterial species. Together, our findings show that ciprofloxacin treatment of S. maltophilia leads to the secretion of a heterogeneous pool of MVs and the induction of prophages that are potentially involved in adverse side‐effects during antibiotic treatment.
Effect of Nanoemulsified and Microencapsulated Mexican Oregano (Lippia graveolens Kunth) Essential Oil Coatings on Quality of Fresh Pork Meat
Authors: Hernández‐Hernández Elvia , Lira‐Moreno César Y. , Guerrero‐Legarreta Isabel , Wild‐Padua Graciela , Di Pierro Prospero , García‐Almendárez Blanca E. , Regalado‐González Carlos 
Published: May 2017

AbstractFresh meat is a highly perishable food. This work aimed to evaluate the influence of Mexican oregano (Lippia graveolens Kunth) incorporated into active coatings (ACs) spread on fresh pork meat as free (FEO), nanoemulsified (NEO), and microencapsulated (MEO) essential oil (EO), on its microbiological, physicochemical and sensory properties during 15 d at 4 ± 1 °C. Thymol and γ‐terpinene were identified in the EO. In vitro effect of 2.85 mg EO/cm2 was tested against Brochothrix thermosphacta, Micrococcus luteus, Lactobacillus plantarum, Pseudomonas fragi, and Salmonella Infantis. FEO antioxidant capacity (DPPH assay) was significantly higher than that of thymol, NEO and MEO (93.53%, 89.92%, 77.79%, and 78.50% inhibition, respectively), and similar to BHA (96.03%) and gallic acid (95.57%). FEO, NEO, and MEO ACs on meat caused growth inhibition of lactic acid bacteria (5 log population reduction) and Pseudomonas spp. (4 log reduction), whereas ≤1.5 log population reduction was observed for B. thermosphacta and Salmonella Infantis. Meat microbiota was more efficiently controlled by MEO than by FEO or NEO. ACs delayed lipid and oxymyoglobin oxidation of fresh pork meat. After 15 d of cold storage meat added with EO coatings was desirable for panelists, whereas untreated (UT) samples were undesirable. Active coatings are a significant alternative method for fresh meat preservation.
Apoptotic Activity of Lactobacillus plantarum DGK‐17‐Fermented Soybean Seed Extract in Human Colon Cancer Cells via ROS–JNK Signaling Pathway
Authors: Khan Imran , Kang Sun Chul 
Published: May 2017

AbstractFermented food has been always possesses upper hand compared to normal food due to its antibacterial, antioxidant, and anticancer properties. Soybeans, which have high nutritional value, are widely consumed in Korea. In this study, soybean seed powder fermented with Lactobacillus plantarum DGK‐17, which was previously isolated from kimchi, showed anticancer potential. Fermented soybean extract (FSE) resulted in morphological changes, reduction of cancer cell colony formation and apoptotic cell death of HCT‐116 colon cancer cells in a dose‐dependent manner, and IC50 value of 111 μg. FSE treatment caused reduction of cell growth in a dose‐dependent manner via release of lactate dehydrogenase. FSE treatment induced HCT‐116 apoptotic cell death as confirmed by the presence of fragmented nuclei, oxidative burst, and reduced mitochondrial membrane potential (ΔΨm). Further, FSE treatment sensitized cells to ER stress via IRE1‐α induction. FSE treatment also resulted in JNK activation, subsequently causing activation of Bax and downregulation of BCl2. Weakened mitochondrial membrane potential (ΔΨm) also caused release of Cyto C, further activating caspase‐mediated cell death. Therefore, this study reveals the apoptotic role of DGK‐17‐fermented soybean seed extract in human colon cancer HCT‐116 cells.
Halting the isolation of jaguars: where to act locally to sustain connectivity in their southernmost population
Authors: Martinez Pardo J. , Paviolo A. , Saura S. , De Angelo C. 
Published: May 2017

AbstractHabitat loss and fragmentation are among the major threats to the conservation of biodiversity. Improvement of landscape connectivity becomes one of the main strategies for alleviating these threats and is an increasingly used target in management policies worldwide. However, implementation of connectivity principles in local management actions often implies great difficulties derived from the different criteria used by connectivity analysts and policy makers. We generated a management tool to incorporate connectivity criteria for large carnivores in landscape conservation planning at a local scale. Focusing on the southernmost population of jaguars Panthera onca, we use a graph‐based connectivity approach to (1) analyze habitat connectivity and availability in five areas previously identified as main corridors; (2) detect priority forest patches for maintaining connectivity, and (3) propose specific management strategies for each area matching the relative importance and role of the forest patches in it. For this purpose, we defined the patches as the local land management units (properties) and used information on land cover and jaguar movement for determining the probabilities of connectivity metric. We identified the key patches that represent 90% of the total contribution to connectivity in the study areas; these patches were less than half of the total number of patches in each corridor. Based on this forest patch prioritization, we identified the most critical areas and specific patches where urgent conservation measures need to be implemented. The percentage of patches and the total area they covered varied among the five analyzed corridors showing contrasting situations for connectivity management and highlighting the importance of the proposed approach to understand the impact of patch‐level actions in a broader connectivity context. This approach might serve as a model to account for habitat connectivity for large carnivores in the design of landscape management and land‐use plans at a local scale.
Landscape context influences leafhopper and predatory Orius spp. abundances in maize fields
Authors: Ardanuy Agnès , Lee Marina S. , Albajes Ramon 
Published: May 2017

Abstract

Biological control relies on the periodical colonization of crops by natural enemies from surrounding habitats. In North‐East Spain, predatory Orius spp. disperse among cereal, maize and alfalfa according to crop phenology and management.
In the present study, we examined (i) the variation of Orius spp. and its leafhopper prey Zyginidia scutellaris populations in co‐occurring habitats (maize, alfalfa and semi‐natural) for 2 years in three regions and (ii) the effects of agricultural landscape context on their abundance in maize.
Variance partitioning revealed that inter‐annual variation accounted for the largest proportion of variation for Orius spp. and its prey. Maize leafhopper abundance was positively related to winter cereal cover in the landscape and negatively related to semi‐natural habitat across the three regions. Orius spp. were unresponsive to shifts in habitat composition despite being present in maize and associated habitats; however, they were positively related to edge density. Larger‐scale variation in Orius spp. abundance was best explained by changes in Z. scutellaris abundance in maize.
Leafhopper colonization is responsible for the recruitment of Orius spp. in maize. Orius spp. conservation in intensive agricultural landscapes might require permanent field margins and complementary crops (e.g. alfalfa) that ensure resource continuity in time.
Addition of oxaliplatin to neoadjuvant radiochemotherapy in MRI‐defined T3, T4 or N+ rectal cancer: a randomized clinical trial
Authors: Haddad Peiman , Miraie Monir , Farhan Farshid , Fazeli Mohammad‐Sadegh , Alikhassi Afsaneh , Maddah‐Safaei Afsaneh , Aghili Mahdi , Kalaghchi Bita , Babaei Mohammad 
Published: May 2017

AbstractBackgroundClinical trials investigating the effects of addition of oxaliplatin to neoadjuvant radiochemotherapy in locally advanced rectal cancers (LARCs) have brought controversial results for pathologic complete response as an endpoint. This randomized clinical trial investigated downstaging as a short‐term surrogate for progression‐free survival (PFS).MethodsPatients with magnetic resonance imaging (MRI) defined T3, T4 or N+ histologically proven adenocarcinoma of rectum within 15 cm from anal verge were randomly assigned to receive 50–50.4 Gy external beam radiation in 25–28 fractions and concurrent capecitabine 825 mg/m2 twice daily 5 days a week with or without oxaliplatin 60 mg/m2 weekly as neoadjuvant radiochemotherapy (Capox and Cap group, respectively). T downstage was defined as at least one stage regression in pathologic report after surgery comparing to MRI image before the preoperative treatment. Adverse effects of treatment were recorded on a weekly basis according to National Cancer Institute Common Toxicity Criteria, version 4.ResultsSixty‐three patients were randomly assigned to Cap (n = 31) and Capox (n = 32) groups. There was no grade 4 toxicity. The only grade 3 toxicity that occurred more in Capox group was diarrhea (22% vs 0%; P = 0.006). Histopathologic stage of 52 patients (27 patients in Cap and 25 patients in Capox groups) was compared to their preoperative stage defined by MRI. There was a greater rate of T downstage in Capox group (59% vs 42%; P = 0.037). Eleven patients in Capox group (34%) achieved pathologic complete response, comparing to four in Cap group (13%); P = 0.072.ConclusionThe addition of oxalipatin to neoadjuvant radiochemotherapy in LARC led to higher rate of tumor downstaging. Longer follow‐up is needed to evaluate PFS.
Patients with cirrhosis who have coronary artery disease treated with cardiac stents have high rates of gastrointestinal bleeding, but no increased mortality
Authors: Krill T. , Brown G. , Weideman R. A. , Cipher D. J. , Spechler S. J. , Brilakis E. , Feagins L. A. 
Published: May 2017

SummaryBackgroundPatients with coronary artery disease (CAD) treated with stents require dual antiplatelet therapy (DAPT). For cirrhotics, who often have varices and coagulopathy, it is not clear if the risk of gastrointestinal bleeding (GIB) should preclude use of DAPT.AimTo compare GIB and mortality rates in cirrhotics with CAD treated medically or with stents.MethodsUsing institutional databases, we identified patients with cirrhosis and CAD treated with stents or medical therapy between January 2000‐September 2015. Primary outcomes were GIB and mortality.ResultsWe identified 148 cirrhotics with CAD; 68 received stents (cases), 80 were treated with medical therapy (controls). Cases and controls had similar demographics, comorbidities, MELD scores and clinical presentation; DAPT was used in 98.5% of cases vs 5% of controls. The incidence of GIB was significantly higher in cases than controls (22.1% vs 5% at 1 year, P=.003; 27.9% vs 5% at 2 years, P=.0002), whereas all‐cause mortality was similar (20.6% vs 21.3%). No patient required surgery or angiography for GIB, and no known patients died due to GIB. Multivariate analysis revealed use of a proton pump inhibitor (PPI) was highly protective against GIB (OR=0.26, 95%CI=0.08‐0.79).ConclusionsCAD treatment with stents in our cirrhotics was associated with a significantly increased risk of GIB, but no adverse effects on survival. Although it remains unclear whether the cardiovascular benefits of stents outweigh the GIB risk, our findings suggest that DAPT should not be withheld from stented cirrhotics for fear of GIB. Moreover, the use of a PPI should be strongly considered.