bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular disease in pregnancy: Prevalence and obstetric outcomes in a Swedish population‐based cohort study between 2000 and 2019
Authors: Svanvik Teresia , Ramakrishnan Rema , Svensson Martin , Albrektsson Henrik , Basic Carmen , Mandalenakis Zacharias , Rosengren Annika , Schaufelberger Maria , Thunström Erik , Knight Marian 
Published: October 2024

AbstractIntroductionThe prevalence of cardiovascular disease during pregnancy (cardiovascular disease diagnosed before, during or up to 6 months after childbirth) and the risk of adverse outcomes associated with it have not been previously described in Sweden. This study examined trends in prevalence of cardiovascular disease and its association with maternal and perinatal outcomes, overall and by timing of diagnosis in relation to pregnancy.Material and MethodsThis population‐based observational retrospective cohort study consisted of women aged 15–49 years who were registered in the Swedish Medical Birth Register 2000–2019. Prevalence was defined as annual diagnosis of cardiovascular disease per pregnant woman as numerator and all pregnant women per year as denominator. Adverse maternal and perinatal outcomes were analyzed using time‐dependent Cox regression and Poisson regression models. Outcomes were obtained during and after childbirth up to 1 year postpartum, depending on the outcome.ResultsThere were 2 069 107 births to 1 186 137 women (911 101 primiparous). The prevalence of cardiovascular disease among pregnant women in Sweden during 2000–2019 increased from 0.31% to 1.34%, for non‐congenital cardiovascular disease, this was primarily driven by arrythmia (0.11%–0.58%). Primiparous women with cardiovascular disease had a higher risk of eclampsia over‐all (aHR 4.50, 95% CI 2.01–10.05) and when diagnosed during pregnancy (aHR 3.22, 95% CI 1.21–8.61); admission to psychiatric ward overall (aHR 2.51, 95% CI 1.30–4.83), and when diagnosed during pregnancy (aHR 2.54, 95% CI 1.21–5.34); and one‐year mortality when diagnosed before pregnancy (aHR 1.67, 95% CI 1.16–2.42) and when diagnosed postpartum (aHR 6.59, 95% CI 3.38–12.84), compared to those without cardiovascular disease. Children born to women with cardiovascular disease diagnosed both overall and in relation to timing of diagnosis had an increased risk of being born preterm and small for gestational age.ConclusionsCardiovascular disease prevalence among pregnant women in Sweden increased during 2000–2019, primarily driven by arrhythmias. In primiparous women, the timing of diagnosis of cardiovascular disease is important for maternal and perinatal outcomes, including when diagnosed postpartum. This calls for awareness among all staff when planning pregnancy and monitoring women with cardiovascular disease throughout pregnancy and in the postpartum period.
High chloride induces aldosterone resistance in the distal nephron
Authors: Vitzthum Helga , Hauswald Nina , Pham Helena , Eckermann‐Reimer Leya , Meyer‐Schwesinger Catherine , Ehmke Heimo 
Published: October 2024

AbstractAimIncreasing the dietary intake of K+ in the setting of a high salt intake promotes renal Na+ excretion even though K+ concurrently enhances the secretion of aldosterone, the most effective stimulus for renal Na+ reabsorption. Here, we questioned whether in the high salt state a mechanism exists, which attenuates the aldosterone response to prevent renal Na+ reabsorption after high K+ intake.MethodsMice were fed diets containing varying amounts of Na+ combined with KCl or KCitrate. Murine cortical connecting duct (mCCDcl1) cells were cultured in media containing normal or high [Cl−]. The response to aldosterone was analyzed by high‐resolution imaging and by biochemical approaches.ResultsThe canonical cellular response to aldosterone, encompassing translocation of the mineralocorticoid receptor (MR) and activation of the epithelial Na+ channel ENaC was repressed in Na+‐replete mice fed a high KCl diet, even though plasma aldosterone concentrations were increased. The response to aldosterone was restored in Na+‐replete mice when the extracellular [Cl−] increase was prevented by feeding a high KCitrate diet. In mCCDcl1 cells, an elevated extracellular [Cl−] was sufficient to disrupt the aldosterone‐induced MR translocation.ConclusionThese findings indicate a pivotal role for extracellular [Cl−] in modulating renal aldosterone signaling to adapt MR activation by a high K+ intake to the NaCl balance. An impairment of [Cl−]‐mediated aldosterone resistance may contribute to excessive MR activation by aldosterone in the presence of a high salt intake characteristic of the Western diet, resulting in an inappropriate salt reabsorption and its downstream detrimental effects.
Ethics and Entrepreneurship: How Recent Unanticipated Externalities Change the Scope A Bibliometric Analysis and Research Agenda
Authors: Mejri Issam , Le Loarne Lemaire Séverine , Bertrand Gael , Maalaoui Adnan , Maran Thomas 
Published: October 2024

ABSTRACTThis paper aims to provide a deeper and more comprehensive understanding of the current state of ethics and entrepreneurship research by using bibliometric and content analysis. Focusing on 579 papers published between 1988 and 2023, it highlights how recent, unanticipated global challenges—such as the need to combat climate change, ongoing conflicts, and pandemics—have profoundly influenced and revitalized the field. The content analysis reveals that “entrepreneurial ethics” has evolved to encompass a broad range of subtopics and debates. We analyzed the data in four time periods: 1988–2002, 2003–2008, 2009–2016, and 2017–2023 to identify the intellectual foundation of each period and the evolution of the research on the topic. What emerges is that recent research on the societal impact of entrepreneurship has expanded significantly, now covering 11 distinct research areas. This indicates that entrepreneurial ethics has become a widespread theme in entrepreneurship research, rather than an isolated sub‐field, with a notable focus on the identities of entrepreneurs, particularly women and family‐owned business. Additionally, this paper contributes to the literature on technology entrepreneurship by highlighting the limited attention given to the ethical issues that entrepreneurs face when working with new technologies and innovation, despite major external shifts in the environment. Furthermore, this research reinforces earlier findings that entrepreneurial ethics remains heavily influenced by the principles of corporate social responsibility (CSR). It also highlights the tendency to conflate entrepreneurial ethics with social entrepreneurship, underscoring the need for a more holistic approach to ethics in entrepreneurship research to better understand the interconnectedness of these two domains.
Climate‐Smart Invasive Species Management for 21st Century Global Change Challenges
Authors: Colberg Eva M. , Bradley Bethany A. , Morelli Toni Lyn , Brown‐Lima Carrie J. 
Published: October 2024

ABSTRACTAddressing the global challenges of climate change and biotic invasions requires understanding their interactions and implications for natural resource management. To facilitate and support invasive species management in a changing climate, we review how climate change and invasions interact to impact the planning, action, and outcomes of invasive species management. Climate change is facilitating the introduction of new potential invasive species and altering pathways of introduction and spread, with implications for which species natural resource managers need to assess, monitor, and target. Climate‐driven shifts in invasive species phenology require more flexible management timelines. Climate change may reduce the efficacy and feasibility of current treatment methods and make native ecosystems more vulnerable to invasion. Additionally, disturbance caused by extreme climate events can compound the spread and impacts of biological invasions, making invasive species management a necessary part of extreme event preparation and response planning. As a solution to these challenges, we propose climate‐smart invasive species management, which we define as the approaches that managers and decision‐makers can take to address the interactive effects of climate change and invasions. Climate‐smart invasive species management includes considering potential shifts in species ranges, abundances, and impacts to inform monitoring, treatment, and policies to prevent new invasive species. Climate‐smart management may also involve adjusting the timing and type of treatment to maintain efficacy, promoting resilient ecosystems through climate‐smart restoration, and considering the effects of climate change when setting management goals. Explicitly considering the interactions of climate change and biological invasions within organizational decision‐making and policy can lead to more effective management and promote more resilient landscapes.
Integrating ERT and SP Techniques for Characterizing Aquifers and Surface‐Groundwater Interactions
Authors: Mamud Md Lal , Holt Robert M. , Hickey Craig J. , O'Reilly Andrew M. , Wodajo Leti T. , Bakhtiari Rad Parsa , Samad Md Abdus 
Published: October 2024

AbstractThis study enhances the understanding of riverbank filtration and improves management of the Mississippi River valley alluvial (MRVA) aquifer during a managed aquifer recharge (MAR) pilot project at Shellmound, MS. Using high‐resolution electrical resistivity tomography (ERT) and self‐potential (SP) geophysical methods, we characterized the heterogeneous MRVA aquifer and monitored groundwater flow near a pumping well. ERT was used to provide detailed spatial characterization, filling gaps left by airborne electromagnetic (AEM) data and soil boring logs, while SP techniques were used to monitor groundwater flow, predict drawdown trends, and investigate surface‐groundwater interactions. Results showed that SP signals were influenced by groundwater flow, river infiltration, and water mixing due to pumping disturbance of natural geochemical stratification, with significant river interaction observed after 1 h of pumping. The integration of ERT and SP methods revealed lithologic heterogeneity, explaining greater drawdowns on the northern side of the well and increased flow from the riverside. This comprehensive approach offers valuable insights into aquifer management and sustainability.
Systematic review and meta‐analysis of non‐SCORTEN predictors of mortality in Stevens‐Johnson syndrome and toxic epidermal necrolysis
Authors: Stewart Thomas Jonathan , Shah Hemali , Frew John 
Published: October 2024

AbstractStevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, severe cutaneous adverse reactions that result in in‐hospital death in 12–49% of cases. The severity‐of‐illness score for toxic epidermal necrolysis (SCORTEN) is the most widely used mortality prognosis score; however, it has been shown to have critical limitations. Other mortality predictors not incorporated in SCORTEN or other predictor tools are being increasingly reported. This systematic review and meta‐analysis aimed to synthesize and evaluate the predictors of mortality in adults with Stevens‐Johnson syndrome and toxic epidermal necrolysis not included in SCORTEN. It was registered with the International Platform of Registered Systematic Review and Meta‐Analysis Protocols (INPLASY) and conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) reporting guidelines. Potential bias was assessed using the National Institutes of Health (NIH) criteria. Forty articles describing results from 52,398 cases were included. Sixteen predictors were reported in five or more articles, and thirty‐three were reported in two to four articles. Meta‐analysis showed preexisting renal disease (odds ratio (OR): 3.14, 95% confidence interval (CI): 1.99–4.97, P < 0.0001, I2 = 21%), renal involvement (OR: 5.62, 95% CI: 2.29–13.77, P = 0.0002, I2 = 36%), respiratory involvement (OR: 3.14, 95% CI: 1.25–7.92, P = 0.015, I2 = 66%), diabetes mellitus (OR: 1.87, 95% CI: 1.21–2.89, P = 0.005, I2 = 19%), sepsis (OR: 5.64, 95% CI: 2.81–11.29, P < 0.0001, I2 = 63%), comorbidity (OR: 9.13, 95% CI: 4.60–18.12, P < 0.0001, I2 = 0%), and time to hospitalization (OR: 2.56, 95% CI: 1.15–5.65, P = 0.021, I2 = 93) increased risk of mortality. This systematic review and meta‐analysis support several clinical and laboratory parameters not included in SCORTEN (preexisting renal disease, renal involvement, respiratory involvement, diabetes mellitus, sepsis, comorbidities, and time to hospitalization) as predictors of mortality in adults with SJS/TEN. The future utilization of these factors may improve mortality prognostication in adults with SJS/TEN.
Association Between Changes in Central Blood Pressure and Peripheral Blood Pressure With New‐Onset Hypertension in a Chinese Community‐Based Population
Authors: Li Kaiyin , Fan Fangfang , Gao Lan , Jia Jia , Jiang Yimeng , Li Jianping , Zhang Yan , Huo Yong 
Published: October 2024

ABSTRACTSpot central and peripheral blood pressure are predictors for future hypertension, but the associations between central or peripheral systolic blood pressure (SBP) changes and new‐onset hypertension are unclear. Annual changes in central and peripheral SBP over a mean interval of 2.36 years were calculated for 815 Chinese community residents without cardiovascular disease and hypertension at the first two visits, with the formula: ([2nd SBP−1st SBP]/1st SBP) × 100%/time interval (years). The independent and joint associations of these SBP changes with new‐onset hypertension at the third visit were assessed with multivariable logistic regression models. During a mean follow‐up interval of 4.37 years since the second visit, 171 new cases of hypertension were observed. Central and peripheral SBP changes were significantly associated with new‐onset hypertension (central SBP change rate: odds ratio [OR]: 1.19 [95% confidence intervals (CI) 1.13, 1.26]; peripheral SBP change rate: OR: 1.25 [95% CI 1.17, 1.33]), even after adjusting for each other. Compared to the group with neither SBP increased, the group with both SBPs increased showed a significantly higher risk of new‐onset hypertension (OR: 4.52 [95% CI 2.54, 8.04]). The model including both SBP changes had a higher area under the curve (AUC) for predicting hypertension in receiver operating characteristic (ROC) analyses than those with either change alone. Central and peripheral SBP changes are independently and jointly associated with new‐onset hypertension. It is recommended to regularly monitor both central and peripheral blood pressures.
The Rise of Remote Work Evidence on Productivity and Preferences From Firm and Worker Surveys
Authors: Bartik Alexander , Cullen Zoë , Glaeser Ed , Luca Michael , Stanton Christopher 
Published: October 2024

ABSTRACTDrawing on surveys of small business owners and employees, we present three main findings about the evolution of remote work after the onset of COVID‐19. First, uptake of remote work was abrupt and widespread in jobs suitable for telework according to the task‐based measure from Dingel and Neiman (2020). The initial adoption lead to a persistent shift in work arrangements that both firms and workers forecast would continue into the future. Second, business leaders' perceptions of how remote work affected productivity shifted over time. In early 2020, 70% of small business owners reported a productivity dip due to remote work. By contrast, the median business owner reported a positive productivity impact of remote work by 2021. Third, 21% of workers report being willing to accept a pay cut in excess of 10% if it allowed them to continue working from home, but the median worker in a teleworkable job would not tradeoff any compensation for the option of continued remote work. Taken together, our evidence points to perceived productivity gains and some workers' preferences as reasons for the persistence of remote work in the years following the onset of COVID‐19.
Ultrasound‐Assisted Extraction of Bioactive Compounds From Sucupira (Pterodon pubescens) Fruit: Chemical Characterization and Antimicrobial Activity
Authors: Alves Israel Luna , Martins Caroline Carboni , Cacciatore Fabíola Ayres , da Silva Malheiros Patricia , Marczak Ligia Damasceno Ferreira , Flôres Simone Hickmann , Mercali Giovana Domeneghini 
Published: October 2024

ABSTRACTThe sucupira fruit (Pterodon pubescens) contains a valuable oil characterized by high levels of fatty acids and an abundance of bioactive compounds, such as flavonoids and terpenoids. This study aimed to evaluate the use of ultrasound‐assisted extraction to obtain sucupira fruit oil through a complete 22 factorial rotational design. The effects of ultrasound intensity (%) and ethanol concentration (%) on lipid content, antioxidant capacity, color, and reducing capacity were assessed. The maximum lipid content was 26.9/100 g, which was significantly higher than that obtained by the Soxhlet method (23.4/100 g). The extract obtained at the optimized conditions (90% ultrasound intensity and 80% ethanol concentration) showed antimicrobial activity against Salmonella and Escherichia coli cocktails. Compounds such as β‐caryophyllene, caryophyllene oxide, α‐humulene, α‐copaene, and spathulenol, responsible for biologically relevant activities, were identified in the extract through GC/GC–MS. HPLC–MS/MS identified compounds such as catechin, luteolin, quercetin, taxifolin, among others.
Central Bank Independence at Low Interest Rates
Authors: GARCÍA BENJAMÍN , SKAPERDAS ARSENIOS 
Published: October 2024

AbstractWe create a new measure of the political pressure faced by the Federal Reserve based on the analysis of transcripts of the Chairs' testimonies to Congress. We find that the use of nontraditional policies at low interest rates led to increased political criticism and that criticism predicts legislative actions that threaten central bank independence. We develop a model where the probability of the monetary authority's future loss of independence is increasing in the use of nontraditional instruments, leading to attenuated monetary responses and higher inflation volatility. This attenuation can be mitigated under an institutional framework with clearly defined targets where the central bank is evaluated by how efficiently it achieves its goals.
Hepatitis B Virus‐Associated Liver Carcinoma: The Role of Iron Metabolism and Its Modulation
Authors: Ali Imran , Muhammad Shoaib , Naqvi Syed Shah Zaman Haider , Wei Lingxi , Yan Wenqi , Khan Muhammad Fiaz , Mahmood Ahmad , Liu Hong , Shah Wahid 
Published: October 2024

ABSTRACTHepatitis B virus (HBV) infection is a significant contributor to the development of hepatocellular carcinoma (HCC), a leading cause of cancer‐related mortality worldwide. Iron, a central co‐factor in various metabolic pathways, plays an essential role in liver function, but its dysregulation can lead to severe health consequences. Accumulation of iron within hepatic cells over time is linked to increased liver injury and is strongly associated with sensitive exposure to a range of conditions, including cirrhosis, fibrosis and ultimately, HCC. This review explores the intricate interplay between iron metabolism and HCC within the context of HBV infection. Hepatic iron overload can arise from liver injury and disruptions in iron homeostasis, causing hepatic necrosis, inflammation, and fibrosis, ultimately culminating in carcinogenesis. Moreover, alterations in serum iron components in HBV‐related scenarios have been observed to impact the persistence of HBV infection. Notably, the progression of HBV‐associated liver damage exhibits distinct characteristics at various stages of liver disease. In addition to elucidating the complex relationship between iron metabolism and HCC in the context of HBV infection, this review also investigates the prognostic implications of systemic iron levels for HCC. Furthermore, it aims to provide a comprehensive understanding of the intricate interplay between iron metabolism and HCC, extending the discussion to the context of hepatitis C virus (HCV) infection. By shedding light on these multifaceted connections, this review aims to contribute to our understanding of the pathogenesis of HBV‐associated HCC and potentially identify novel therapeutic avenues for intervention.
The Camden and Islington Viral Hepatitis Identification Tool (CIVHIT): Use of a Clinical Database Case‐Finding Tool for Hepatitis B, Hepatitis C and HIV in Primary Care
Authors: Etoori David , Cococcia Sara , Srivastava Ankur , Flanagan Stuart , Nixon Grainne , Bobba Satya , Warner Alex , Sennett Karen , Sabin Caroline , Morgan Sarah , Rosenberg William M. 
Published: October 2024

ABSTRACTDespite the availability of effective treatment and vaccines for hepatitis B virus (HBV) and C virus (HCV), many people are still infected and remain unaware of their infection. The Camden and Islington Viral Hepatitis Identification Tool (CIVHIT), a computer‐based search tool, was introduced in 60 general practices (GPs) in April 2014 to support identification, testing and treatment of individuals at high risk for blood‐borne viruses (BBVs). CIVHIT searched electronic medical records (EMRs), flagging all those with codes linked to risk factors or medical conditions associated with BBVs. CIVHIT was associated with a 78.5% increase in BBV tests in primary care in both boroughs. This translated to a 55.8% rise in new diagnoses. HBV testing saw the largest increase resulting in twice as many people diagnosed. Only 23.2% of HBV and 14.9% of HCV‐positive tests were referred to secondary care. In an index practice, the most common flag was a history of STIs (477/719, 66.3%). Individuals with previous or current drug use and those with a known hepatitis contact were more likely to be offered a test compared to those flagged due to a history of STI. HIV and HBV testing was lower in males following a test offer. There was an increased likelihood of testing for HBV and HCV with increasing age. Additionally, individuals with previous or current drug use and individuals with a known hepatitis contact were more likely to test for HCV compared to individuals flagged due to STI history. CIVHIT shows promise to assist with the elimination of BBVs.
Modal identification of wind turbine tower based on optimal fractional order statistical moments
Authors: Yang Yang , Wang Zhewei , Tao Shuai , Yang Qingshan , Chai Hwa Kian 
Published: October 2024

AbstractIn vibration testing of civil engineering structures, the first two vibration modes are crucial in representing the global dynamic behavior of the structure measured. In the present study, a comprehensive method is proposed to identify the first two vibration modes of wind turbine towers, which is based on the analysis of fractional order statistical moments (FSM). This study offers novel contributions in two key aspects: (1) theoretical derivations of the relationship between FSM and vibration mode; and (2) successful use of 32/7‐order displacement statistical moment as the optimal FSM to identify wind turbine tower modes, by combining with noise resistance analysis, sensitivity analysis, and stability analysis, respectively. Using the proposed method, the FSM was first used to identify the modal vibration of wind turbine towers. By obtaining the response of the structure on the same vertical line, FSM was then calculated to estimate the corresponding structural modal vibration. Considering other influencing factors in the field test, the modal identification results of this index under different excitation forms and noise conditions were analyzed based on numerical simulation and verified with field wind tower test data. The results of the evaluation show that the proposed statistical moments of can accurately identify the first two vibration modes of wind turbine towers. This presents a new robust method for modal vibration identification, that is, simple and effective in its implementation.