bluuebunny/crossref_metadata_2025_split huggingface dataset:
Achieving super high yield in rice by simultaneously increasing panicle number and grain weight via improving pre-heading biomass production
Authors: Huang Min , Xiao Zhengwu , Fang Shengliang , Zhang Hengdong , Liu Longsheng , Cao Fangbo , Chen Jiana 
Published: September 2024

Abstract
Understanding the yield attributes of rice crops grown at super high-yielding sites is useful for identifying how to achieve super high yield in rice. In this study, field experiments were conducted in 2021 and 2022 to compare grain yield and yield attributes of ten high-yielding hybrid rice varieties between Xingyi (a super high-yielding site) and Hengyang (a site with typical yields). Results showed that Xingyi produced an average grain yield of 13.4 t ha−1 in 2021 and 14.0 t ha−1 in 2022, which were, respectively, 20% and 44% higher than those at Hengyang. Higher panicles per m2 and higher grain weight were responsible for the higher grain yield at Xingyi compared to Hengyang. The higher values of panicles per m2 and grain weight at Xingyi compared to Hengyang were due to greater source capacity resulting from improved pre-heading biomass production. This study suggests that simultaneously increasing panicle number and grain weight through improving pre-heading biomass production is a potential way to achieve super high yield in rice.
A local collision-free motion planning strategy for hyper-redundant manipulators based on dynamic safety envelopes
Authors: Ju Renjie , Zhang Dong , Gai Yan , Cao Zhengcai 
Published: September 2024

AbstractHyper-redundant manipulators (HRMs) exhibit promising adaptability and superior dexterity in cavity detection tasks, owing to their snake-like segmented backbones. Due to the safety concern in contactless operating tasks, reliable motion planning in a confined environment for HRMs is very challenging. However, existing expanding-based obstacle avoidance methods are not feasible in narrow environments, as they will excessively occupy free spaces required for maneuvering. In this work, a local collision-free motion planning strategy based on dynamic safety envelope (DSE) is proposed for HRMs. First, the local motion of HRMs is analyzed in detail, and DSE is proposed for the first time to describe the boundary of the collision-free area. Then, to maximize the efficient utilization of narrow spaces, a reference trajectory for HRM is roughly planned without expanding obstacles. Further, a tip-guided trajectory tracking method based on configuration prediction is proposed by considering the discrete characteristics of rigid links to avoid obstacles. During the tracking process, DSEs are applied to evaluate collision risk and optimize the configuration. Finally, to validate the effectiveness of our proposed method, simulations are conducted, followed by experiments by using a 18-degrees of freedom mobile HRM prototype system.
Mainstream and deviating ideologies in Japanese gubernatorial elections
Authors: Hijino Ken Victor Leonard 
Published: September 2024

Abstract
The ideological conflicts of Japan's subnational politics have tended to be interpreted as either being largely muted or contained within national dimensions. Following two decades of substantial decentralization and growing local autonomy, however, a diversity of new ideological responses to local issues have appeared. These include neo-liberal parties and executives in wealthier regions such as Tokyo and Osaka or a rising regionalist identity politics such as that found in Okinawa. Nativist right and populist left along with single-issue parties are also now fielding candidates for subnational elections. Despite this increasingly crowded field, there is still no systematic understanding of the divergent ideological worldviews and dimensions of conflict operating at the subnational level. Nor do we know how these worldviews “deviate” from the traditional “norm” of a progressive vs. conservative conflict dimension assumed to characterize Japanese subnational politics. This paper begins to fill this gap by investigating the campaign discourse of gubernatorial candidates both before and after the pandemic outbreak. We find that the language, and underlying ideological orientation, of these candidates can be separated into four clusters: “mainstream”, “old left”, “neo-liberal”, and “fringe”. In addition, “regionalist” and “new left” populism can also be identified in select elections.
Why did England change its law on deceased organ donation in 2019? The dynamic interplay between evidence and values
Authors: Williams Lorraine , Bostock Jennifer , Noyes Jane , McLaughlin Leah , O'Neill Stephen , Al-Haboubi Mustafa , Boadu Paul , Mays Nicholas 
Published: September 2024

AbstractIn the three years since the law on adult deceased organ donation consent in England changed to include an opt-out system, there has been no discernible change to donation rates. The lack of a positive impact on donation rates was predicted by many of those who took part in debates before and during the passage of the Bill through Parliament. This invites the question as to why England moved to an opt-out system for organ donation despite equivocal evidence of likely benefit and opposition from expert health professional organisations. To address this question qualitative analyses of Parliamentary debates on organ donation was undertaken. This revealed a shift from a dominant position, which gave primacy to the evidence of likely effects, towards a more normative position where a deemed consent option was viewed as the ‘correct thing to do’ and the limited and conflicting evidence viewed in a positive light. By 2017, following Wales's move to an opt-out system, together with continued lobbying for similar changes for England by professional and patient groups, alongside sustained public popularity for organ donation, the balance of opinion had shifted towards a system where deemed consent would become the default position for most English adults
Adapting low-intensity cognitive behavioural therapy for autistic adults: lessons from Plymouth’s NHS Talking Therapies and Autism Spectrum Service
Authors: Trimmer Hope , Heintz Sonja , Williams Sarah 
Published: September 2024

Abstract
The prevalence of mental health conditions is high for autistic adults. Yet, the IAPT manual states that referral rates into NHS Talking Therapies Services (NHS-TTS) do not reflect this nationally. Non-adapted treatment has been identified as a key barrier to accessing these services. It is therefore imperative that clinicians adapt to the needs of autistic individuals to make treatment accessible and effective. However, there is limited research in the field, especially for low-intensity cognitive behavioural therapy (LICBT). This service evaluation explores adapted LICBT for autistic adults within Plymouth’s NHS-TTS and Autism Service. It investigated clinical outcomes of adapted group and one-to-one LICBT with 84 participants. It hypothesised that psychometric measures for anxiety and depression would be lowered on treatment completion, whilst exploring whether either intervention showed a greater reduction. Additionally, semi-structured interviews were conducted with six participants from the sample to gather perspectives on what aspects of treatment were favourable or require improvement. A factorial ANOVA revealed that psychometric measures reduced on completion across both interventions, with a greater decrease for one-to-one treatment and the anxiety measure. In addition, four themes and nine subthemes emerged following a thematic analysis, which focus on different aspects of treatment, such as content, structure, interaction, and barriers to engagement. Findings indicated that adapted LICBT was associated with lower anxiety and depression for autistic adults. This consequently has implications for improving the current LICBT provisions being offered to autistic adults within the NHS-TTS.

Key learning aims

(1)
To understand some of the barriers autistic people face accessing an NHS Talking Therapies Service (NHS-TTS) and cognitive behavioural therapy (CBT).

(2)
To reflect on the importance of adapting practice and CBT for autistic people.

(3)
To present potential adaptations to low-intensity CBT for autistic adults with anxiety and depression.
Effect of coercive measures on mental health status in adult psychiatric populations: a nationwide trial emulation
Authors: Baggio S. , Kaiser S. , Huber C.G. , Wullschleger A. 
Published: September 2024

Abstract

Aims
Healthcare staff use coercive measures to manage patients at acute risk of harm to self or others, but their effect on patients’ mental health is underexplored. This nationwide Swiss study emulated a trial to investigate the effects of coercive measures on the mental health of psychiatric inpatients at discharge.

Methods
We analysed retrospective longitudinal data from all Swiss adult psychiatric hospitals that provided acute care (2019–2021). The primary exposure was any coercive measure during hospitalization; secondary exposures were seclusion, restraint and forced medication. Our primary outcome was Health of the Nations Outcome Scale (HoNOS) score at discharge. We used inverse probability of treatment weighting to emulate random assignment to the exposure.

Results
Of 178,369 hospitalizations, 9.2% (n = 18,800) included at least one coercive measure. In patients exposed to coercive measures, mental health worsened a small but statistically significant amount more than in non-exposed patients. Those who experienced at least one coercive measure during hospitalization had a significantly higher HoNOS score (1.91-point, p < .001, 95% confidence interval [CI]: 1.73; 2.09) than those who did not experience any coercive measure. Results were similar for seclusion (1.60-point higher score, p < .001, 95% CI: 1.40; 1.79) and forced medication (1.97-point higher score, p < .001, 95% CI: 1.65; 2.30). Restraint had the strongest effect (2.83-point higher score, p < .001, 95% CI: 2.38; 3.28).

Conclusions
Our study presents robust empirical evidence highlighting the detrimental impact of coercive measures on the mental health of psychiatric inpatients. It underscores the importance of avoiding these measures in psychiatric hospitals and emphasized the urgent need for implementing alternatives in clinical practice.
Deradicalization and the Experience of Governing: Evidence from the Transformation of Socialist Parties in Western Europe, 1945–2021
Authors: Tiratelli Matteo 
Published: September 2024

AbstractThe question of deradicalization looms large in the historiography of western European socialism. But in this contested field, the contributions of the New Left historian, Ralph Miliband, have been curiously neglected. Through his work on the British Labour Party, Miliband developed a distinctive account of deradicalization that foregrounds the fact that when parties enter government, party elites find themselves transplanted into new, alien institutions. Over time, he argued, they then come to internalize the worldviews of those institutions and reshape their parties accordingly. This essay presents the first quantitative and cross-national test of this “experience of governing hypothesis,” using Comparative Manifesto Project data from western European socialist parties between 1945 and 2021 and a novel matching technique for panel data. Miliband’s theory is strongly supported by this analysis, which also demonstrates the value of taking a multi-dimensional approach to deradicalization.
Sampling Error of Mean and Trend of Nighttime Air Temperature at Weather Stations Over China Using Satellite Data as Proxy
Authors: Chen Linghong , Wang Kaicun 
Published: September 2024

AbstractMeteorological observations of surface air temperature have provided fundamental data for climate change detection and attribution. However, the weather stations are unevenly distributed, and are still very sparse in remote regions. The possible sampling error is well known, but not well quantified because we are lack of the adequate and regularly distributed measurements. The high resolution of satellite land surface temperature retrieval during night time provide a nice proxy for near surface temperature as both temperatures controlled by surface longwave radiative cooling and the nocturnal temperature inversion depress land‐atmosphere turbulent exchange. The sampling error of mean value and trend were assessed by comparing station point measurements (pixel of ∼0.01°) with grid (1°) mean and national mean from 2001 to 2021. This method permits us to make the first assessment of under‐sampling error and spatial representative error on both national mean and trend of air temperature during nighttime collected at ∼2,400 weather stations over China. The sampling error in national mean temperature is more than 3°C. The under‐sampling error due to lack of observation explains two thirds and the spatial representative error due to the difference between station and grid/regional mean elevation contribute the other one third. The sampling error in trend account for one third of the national mean trend. The urban heat island effect associated with urbanization around the weather stations (spatial representative error) can explain four fifths of the sampling error in trend, which is consistent with existing studies based on air temperature collected at paired weather station.
Predictors of mortality and severe illness from Escherichia coli sepsis in neonates
Authors: Hoffman Adriana , Satyavolu Sriram , Muhanna Danah , Malay Sindhoosha , Raffay Thomas , Windau Anne , Ransom Eric M. , Mukherjee Devashis 
Published: September 2024

AbstractNeonatal Escherichia coli (E. coli) sepsis is increasing. There is limited data on the factors contributing to increased mortality and severity of illness in neonatal E. coli sepsis. A retrospective review of neonates (<30 days) admitted to a Level IV NICU in the United States from 2008 to 2022 diagnosed with E. coli bloodstream or cerebrospinal fluid infection was conducted. Primary outcome was defined as mortality from or severe illness during E. coli infection (defined as a need for inotropic support or metabolic acidosis). E. coli neonatal sepsis rate increased from 2008 to 2022 (average of 1.12 per 1000 live births). The primary outcome, which occurred in 57.4% of cases, was independently associated with prematurity, neutropenia, and thrombocytopenia. Ampicillin resistance was not associated with the primary outcome. GA, neutropenia, and thrombocytopenia but not ampicillin resistance, are associated with mortality or severe illness from E. coli sepsis.
Molecular and micro-architectural mapping of gray matter alterations in psychosis
Authors: García-San-Martín Natalia , Bethlehem Richard A. I. , Mihalik Agoston , Seidlitz Jakob , Sebenius Isaac , Alemán-Morillo Claudio , Dorfschmidt Lena , Shafiei Golia , Ortiz-García de la Foz Víctor , Merritt Kate , David Anthony , Morgan Sarah E. , Ruiz-Veguilla Miguel , Ayesa-Arriola Rosa , Vázquez-Bourgon Javier , Alexander-Bloch Aaron , Misic Bratislav , Bullmore Edward T. , Suckling John , Crespo-Facorro Benedicto ,   Lifespan Brain Chart Consortium, Romero-García Rafael 
Published: September 2024

AbstractThe psychosis spectrum encompasses a heterogeneous range of clinical conditions associated with abnormal brain development. Detecting patterns of atypical neuroanatomical maturation across psychiatric disorders requires an interpretable metric standardized by age-, sex- and site-effect. The molecular and micro-architectural attributes that account for these deviations in brain structure from typical neurodevelopment are still unknown. Here, we aggregate structural magnetic resonance imaging data from 38,696 healthy controls (HC) and 1256 psychosis-related conditions, including first-degree relatives of schizophrenia (SCZ) and schizoaffective disorder (SAD) patients (n = 160), individuals who had psychotic experiences (n = 157), patients who experienced a first episode of psychosis (FEP, n = 352), and individuals with chronic SCZ or SAD (n = 587). Using a normative modeling approach, we generated centile scores for cortical gray matter (GM) phenotypes, identifying deviations in regional volumes below the expected trajectory for all conditions, with a greater impact on the clinically diagnosed ones, FEP and chronic. Additionally, we mapped 46 neurobiological features from healthy individuals (including neurotransmitters, cell types, layer thickness, microstructure, cortical expansion, and metabolism) to these abnormal centiles using a multivariate approach. Results revealed that neurobiological features were highly co-localized with centile deviations, where metabolism (e.g., cerebral metabolic rate of oxygen (CMRGlu) and cerebral blood flow (CBF)) and neurotransmitter concentrations (e.g., serotonin (5-HT) and acetylcholine (α4β2) receptors) showed the most consistent spatial overlap with abnormal GM trajectories. Taken together these findings shed light on the vulnerability factors that may underlie atypical brain maturation during different stages of psychosis.
A home-based self-directed EEG neurofeedback intervention for people with chronic neuropathic pain following spinal cord injury (the StoPain Trial): description of the intervention
Authors: Hesam-Shariati Negin , Alexander Lara , Chen Kevin Yi , Craig Ashley , Glare Paul A. , Jensen Mark P. , Lin Chin-Teng , McAuley James H. , Middleton James W. , Moseley G. Lorimer , Newton-John Toby , Restrepo Sebastian , Skinner Ian W. , Zahara Pauline , Gustin Sylvia M. 
Published: September 2024

Abstract
Study design
Randomised controlled trial.

Objectives
The objective is to describe an electroencephalography (EEG) neurofeedback intervention that will be provided in a randomised controlled trial for people with neuropathic pain following spinal cord injury (SCI): the StoPain Trial. In this trial, participants in the treatment group will implement an EEG neurofeedback system as an analgesic intervention at home, while participants in the control group will continue with the treatments available to them in the community.

Setting
University-based study in Sydney, Australia.

Methods/results
This manuscript describes the rationale and components of the EEG neurofeedback intervention designed for individuals with SCI neuropathic pain and intended for home-based implementation. Our report is based on the criteria of the Template for Intervention Description and Replication (TIDieR) checklist, and includes why the efficacy of EEG neurofeedback will be investigated, what will be provided, who will administer it, and how, where, when, and how much the EEG neurofeedback intervention will be administered.

Conclusions
This manuscript provides a detailed description of a complex intervention used in a randomised controlled trial. This description will facilitate the subsequent interpretation of the trial results and allow for the replication of the intervention in clinical practice and future trials.

Sponsorship
Australian Government Medical Research Future Fund (2020 Rare Cancers Rare Diseases and Unmet Needs Scheme: 2006020).
Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3—their sensing mediator—is tumor suppressive
Authors: Livneh Ido , Fabre Bertrand , Goldhirsh Gilad , Lulu Chen , Zinger Adar , Shammai Vainer Yael , Kaduri Maya , Dahan Aviva , Ziv Tamar , Schroeder Avi , Ben-Neriah Yinon , Zohar Yaniv , Cohen-Kaplan Victoria , Ciechanover Aaron 
Published: September 2024

AbstractThe proteasome, the catalytic arm of the ubiquitin system, is regulated via its dynamic compartmentation between the nucleus and the cytoplasm, among other mechanisms. Under amino acid shortage, the proteolytic complex is translocated to the cytoplasm, where it stimulates proteolysis to supplement recycled amino acids for essential protein synthesis. This response is mediated via the mTOR pathway and the lack of the three aromatic amino acids Tyr, Trp, and Phe (YWF). mTOR activation by supplementation of the triad inhibits proteasome translocation, leading to cell death. We now show that tumoral inherent stress conditions result in translocation of the proteasome from the nucleus to the cytosol. We further show that the modulation of the signaling cascade governed by YWF is applicable also to non-starved cells by using higher concentration of the triad to achieve a surplus relative to all other amino acids. Based on these two phenomena, we found that the modulation of stress signals via the administration of YWF leads to nuclear proteasome sequestration and inhibition of growth of xenograft, spontaneous, and metastatic mouse tumor models. In correlation with the observed effect of YWF on tumors, we found – using transcriptomic and proteomic analyses – that the triad affects various cellular processes related to cell proliferation, migration, and death. In addition, Sestrin3—a mediator of YWF sensing upstream of mTOR—is essential for proteasome translocation, and therefore plays a pro-tumorigenic role, positioning it as a potential oncogene. This newly identified approach for hijacking the cellular “satiety center” carries therefore potential therapeutic implications for cancer.
Clinical features, risk factors and outcomes of contact lens-related bacterial keratitis in Nottingham, UK: a 7-year study
Authors: Suresh Lakshmi , Hammoudeh Yasmeen , Ho Charlotte S. , Ong Zun Zheng , Cairns Jessica , Gopal Bhavesh P. , Krstic Lazar , Elsahn Ahmad , Lister Michelle M. , Said Dalia G. , Dua Harminder S. , Ting Darren S. J. 
Published: September 2024

Abstract
Background/Objectives
To examine the clinical characteristics, risk factors and outcomes of contact lens-related bacterial keratitis (CLBK) in a large UK tertiary referral centre.

Subjects/Methods
A retrospective analysis of all patients who presented to the Queen’s Medical Centre, Nottingham, UK, with suspected CLBK between October 2015 to September 2022 (a 7-year period) was performed. Relevant data on demographic factors, CL wear behaviour, causes, clinical characteristics, and outcomes were analysed.

Results
We included 138 patients with CLBK; the mean age was 42.0 ± 17.8 years and 74 (53.6%) patients were male. Most CLBK were related to soft CL wear (94.5%), particularly monthly disposable (42.5%) and daily disposable (24.4%) CLs. Poor CL wear behaviour/hygiene was documented in 57.1% cases. Among the 64 (46.4%) microbiological-positive cases (n = 73 organisms), Pseudomonas aeruginosa (36, 49.3%) and Staphylococcus spp. (16, 21.9%) were most commonly identified. Six (4.3%) cases were polymicrobial. Most (97.0%) patients were successfully treated with topical antibiotics alone, with 80.6% achieving good final corrected-distance-visual-acuity (CDVA) of ≥ 0.30 logMAR. Poor visual outcome (final CDVA < 0.30 logMAR) was significantly associated with presenting CDVA < 0.6 logMAR (p = 0.002) and central ulcer (p = 0.004). Poor corneal healing (complete healing of > 30 days from initial presentation) was significantly associated with age > 50 years (p = 0.028), female gender (p = 0.020), and infiltrate size >3 mm (p = 0.031).

Conclusions
Poor CL wear behaviour/hygiene is commonly observed in CLBK, highlighting the importance of improved counselling and awareness regarding CL use and hygiene. When presented early and managed appropriately, most patients are able to achieve good clinical outcomes with medical treatment alone.