bluuebunny/crossref_metadata_2025_split huggingface dataset:
Within‐episode relations among simultaneous alcohol and cannabis use and continued drinking: The role of momentary subjective responses, craving, and drinking context
Authors: Waddell Jack T. , Corbin William R. , Grimm Kevin J. , Metrik Jane , Lee Christine M. , Trull Timothy J. 
Published: October 2024

AbstractBackgroundSimultaneous alcohol and cannabis use is associated with riskier daily drinking. However, little research has tested momentary mechanisms through which simultaneous use predicts continued drinking during acute drinking episodes. The current study tested whether simultaneous use moments predicted within‐episode increases in subjective responses, craving, and continued drinking, and whether these relations were potentiated in social versus solitary settings.MethodsEmerging adults who co‐use alcohol and cannabis (N = 85) completed 21 days of ecological momentary assessment with event‐contingent reports during drinking episodes. Three‐level multilevel models tested whether simultaneous (vs. alcohol‐only) use moments indirectly predicted subsequent, continued drinking through subjective responses (i.e., high‐arousal positive/stimulant, high‐arousal negative/aggression, low‐arousal positive/relaxation, low‐arousal negative/impairment) and alcohol craving, and whether relations differed by social versus solitary contexts.ResultsWithin drinking episodes, simultaneous (vs. alcohol‐only) use moments were associated with increased stimulation, which was indirectly associated with continued drinking through increased alcohol craving. Additionally, the relation between simultaneous (vs. alcohol‐only) use and stimulating effects was potentiated during solitary drinking moments, whereas the relation between stimulating effects and craving was potentiated during social drinking moments. However, stimulating effects were higher in social contexts across all moments. Finally, simultaneous (vs. alcohol‐only) use moments were associated with increased relaxation, which was indirectly associated with a lower likelihood of continued drinking through lesser craving.ConclusionsSimultaneous use predicted both continued within‐episode drinking and cessation of drinking, with acute subjective effects and craving as mechanisms, dependent upon context. Just‐in‐time interventions should consider targeting affect, craving, and context in event‐specific interventions.
Systematic scoping review of ageing in place strategies in Japan, Singapore and Thailand: A comparative analysis
Authors: Satchanawakul Nattanee , Liangruenrom Nucharapon , Thang Leng Leng , Satchanawakul Napaphat 
Published: October 2024

AbstractObjectiveGiven the differing cultural contexts and service needs of older persons in the west and the east, programs or policies should be thoughtfully redesigned to accommodate these diverse societies. This paper presents a systematic scoping review of ageing in place (AIP) strategies in Japan, Singapore and Thailand, emphasising how they are tailored to address the unique challenges of ageing populations in Asia.MethodsA systematic literature search was conducted through seven databases. Empirical, peer‐reviewed studies in English that discussed AIP‐related programs or policies involving aged populations in the target countries were included. Themes were identified using the policy triangle framework, allowing for a comprehensive comparison of AIP across the countries.ResultsThree key components of AIP, place, support network and workforce, were identified from 44 included studies. Each country exhibits distinctive approaches to implementing these components. Japan has extensive AIP systems with comprehensive services and strong community and family support. Singapore offers innovative aged care with significant government involvement, though on a smaller scale. Thailand's localised initiatives focus on community health care and age‐friendly city assessments, with a less developed AIP infrastructure.ConclusionsThe study proposes a comprehensive framework for developing ageing policies in Asia, emphasising the need for a person‐centred approach in developing AIP strategies that cater to the diverse needs of ageing populations, and underscores the importance of integrating health‐care services, community support and home environment modifications. The three AIP elements advocate for a person‐centred approach, providing valuable insights for policymakers to effectively manage challenges of rapidly ageing populations.
Cost‐utility of sirolimus in the treatment of vascular malformations
Authors: Li Grace Xiaoying , Sebaratnam Deshan Frank 
Published: October 2024

AbstractSirolimus is being increasingly employed to manage specific vascular anomalies. We performed an exploratory cost‐utility analysis to evaluate sirolimus as a treatment for vascular malformations from the Australian healthcare system perspective. Over a one‐year time horizon, sirolimus treatment was associated with an increased expenditure of AU$2832.80 and a gain of 0.08 quality‐adjusted life years (QALYs) when compared to supportive care, resulting in an incremental cost‐effectiveness ratio of AU$35,410/QALY. By most metrics, sirolimus would be considered a cost‐effective treatment for vascular malformations.
Media Attention and Labor Investment Efficiency*
Authors: Park Sohee , Cho Meeok 
Published: October 2024

AbstractThis study investigates whether firms make efficient labor investment decisions in response to media attention. The results show that media attention lowers labor investment efficiency, not through over‐firing but through over‐hiring, under‐firing, or under‐hiring. We interpret these findings as firms' intentional adjustment of their labor resources to recover from or preempt reputational damage. Overall, the media's pressure effects on labor investment efficiency suggest that media coverage can serve as friction in firms' labor investment decisions, highlighting the relatively unexplored role of the media compared with its monitoring function.
Characterising umbrella reviews in paediatrics: A systematic analysis
Authors: Kuitunen Ilari 
Published: October 2024

AbstractAimTo characterise typical practices in conducting and reporting umbrella reviews in paediatrics.MethodsPubMed database was searched for umbrella reviews focusing on children (0–18 years) published from 1 January 2020 to 15 June 2024, regardless of the speciality. The included studies were assessed for reporting practices, result summarisation and critical appraisal methods.ResultsNinety‐nine eligible umbrella reviews were included, of which 49 focused on interventions and 50 focused on epidemiology. The median number of included reviews in the umbrella reviews was 18 (range = 3–302), and statistical synthesis was performed in 32 studies. The most frequently used tool for critical appraisal of the included reviews was the updated Assessing the Methodological Quality of Systematic Reviews (AMSTAR‐2) tool (n = 56); the original AMSTAR‐1 tool was used in seven reviews, and the Risk of Bias in Systematic Reviews tool was used in 12 reviews. Evidence certainty was assessed using the Grading of Recommendations Assessment, Development and Evaluation framework in 14 reviews and by the Ioannidis criteria in 18 reviews.ConclusionUmbrella reviews have heterogeneous characteristics in terms of reporting practices. Greater adherence to guidelines on conducting and reporting umbrella reviews is needed, particularly for improving critical appraisal methods.
Letter: Allostatic load and adverse prognosis in inflammatory bowel disease—Need more evidence
Authors: Xu Lingyu , Guan Chen , Zhao Long , Xu Yan 
Published: October 2024

LINKED CONTENTThis article is linked to Zhao et al papers. To view these articles, visit https://doi.org/10.1111/apt.18217 and https://doi.org/10.1111/apt.18303
Editorial: Predictive Factors and Survival Outcome of Conversion Therapy for Unresectable Hepatocellular Carcinoma Patients Receiving Atezolizumab and Bevacizumab: Comparative Analysis of Conversion, Partial Response and Complete Response Patients
Authors: Gorgulho Joao , von Felden Johann 
Published: October 2024

LINKED CONTENTThis article is linked to Hatanaka et al papers. To view these articles, visit https://doi.org/10.1111/apt.18237 and https://doi.org/10.1111/apt.18319.
Editorial: Distinct Challenges of Paediatric From Adult‐Onset Inflammatory Bowel Disease, Implications of Aggressive Disease Phenotypes and Early Biologic Therapy in Children
Authors: Molinaro Alessandro , de Ridder Lissy 
Published: October 2024

LINKED CONTENTThis article is linked to Granot et al papers. To view these articles, visit https://doi.org/10.1111/apt.18264 and https://doi.org/10.1111/apt.18310.
Letter: Allostatic Load and Adverse Prognosis in Inflammatory Bowel Disease—Need More Evidence. Authors' Reply
Authors: Zhao Jianhui , Xue Erxu , Liu Zhanju , Li Xue 
Published: October 2024

LINKED CONTENTThis article is linked to Zhao et al papers. To view these articles, visit https://doi.org/10.1111/apt.18217 and https://doi.org/10.1111/apt.18249.
Editorial: Distinct Challenges of Paediatric From Adult‐Onset Inflammatory Bowel Disease, Implications of Aggressive Disease Phenotypes and Early Biologic Therapy in Children—Authors' Reply
Authors: Granot Maya , Weiss Batia , Haberman Yael 
Published: October 2024

LINKED CONTENTThis article is linked to Granot et al papers. To view these articles, visit https://doi.org/10.1111/apt.18264 and https://doi.org/10.1111/apt.18299.
Network Meta‐Analysis: Histologic and Histo‐Endoscopic Improvement and Remission With Advanced Therapy in Ulcerative Colitis
Authors: Estevinho Maria Manuela , Sousa‐Pinto Bernardo , Moreira Paula Leão , Solitano Virginia , Mesquita Pedro , Costa Catarina , Peyrin‐Biroulet Laurent , Danese Silvio , Jairath Vipul , Magro Fernando 
Published: October 2024

ABSTRACTBackgroundHistology has prognostic value in ulcerative colitis (UC). However, direct comparisons of histological endpoints are lacking.AimTo perform a network meta‐analysis (NMA) to compare histological endpoints with biologics and small molecules.MethodsWe searched four databases up until July 2024 for randomised controlled trials (RCTs) on advanced therapies for moderate‐to‐severe UC reporting histological endpoints. Outcomes included histological improvement or remission, and histo‐endoscopic improvement after induction or during maintenance. We used a random‐effects frequentist model and have reported outcomes as relative risk and 95% confidence interval. We estimated relative drug efficacy with the P‐score. We conducted subgroup analysis by trial phase and evaluated risk of bias and evidence certainty.ResultsWe included 24 RCTs (15 therapies, 8874 patients). Nineteen provided data on induction and 10 on maintenance; outcome definitions were similar. Etrasimod 2 mg/day ranked highest in achieving histologic improvement (P‐score 0.98) and remission (P‐score 0.90) following induction. Globally, guselkumab 200–400 mg ranked first for histo‐endoscopic improvement, while etrasimod 2 mg/day and upadacitinib 45 mg/day were superior in the subgroup analysis. During maintenance, upadacitinib 30 mg/day was superior in achieving histologic improvement and remission (P‐score 0.88 for both) and histo‐endoscopic improvement (P‐score 0.94). Etrasimod 2 mg/day ranked second for histologic remission (P‐score 0.70) and histo‐endoscopic improvement (P‐score 0.73), while mirikizumab 200 mg/month ranked second for histologic improvement.ConclusionThese results support the ability of small molecules to achieve stringent endpoints in moderate‐to‐severe UC. Histological outcome data for biologics was sparser, particularly during maintenance. Head‐to‐head RCTs are imperative to better inform clinical practice.
Editorial: Predictive Factors and Survival Outcome of Conversion Therapy for Unresectable Hepatocellular Carcinoma Patients Receiving Atezolizumab and Bevacizumab: Comparative Analysis of Conversion, Partial Response and Complete Response Patients. Authors' Reply
Authors: Hatanaka Takeshi , Kakizaki Satoru , Hiraoka Atsushi , Tada Toshifumi , Kumada Takashi 
Published: October 2024

LINKED CONTENTThis article is linked to Hatanaka et al papers. To view these articles, visit https://doi.org/10.1111/apt.18237 and https://doi.org/10.1111/apt.18296.
Health Interventions to Improve Work and Well‐Being Among Child Welfare Workers: A Scoping Review
Authors: Olaniyan Oyeniyi Samuel , Hetland Hilde 
Published: October 2024

ABSTRACTThe work environment among child welfare workers (CWW) has often been described as intensive and complex, filled with uncountable negative experiences for CWW. Several authors have also pointed out that measures should be in place to curb these negative workplace experiences. Since most recent publications within the field points to the impact of psychosocial risks on the health and well‐being on CWW, the current scoping review explored the literature to investigate existing intervention studies and provide recommendations for future research. We employed the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis extension for scoping Reviews (PRISMA‐ScR) checklist as a guide for reporting findings. The authors explored five databases and identified a total of nine primary studies investigating health and well‐being intervention among CWW in the review. Based on the intervention focuses of the included studies, three overarching thematic categories were constructed: design team‐based interventions, colleagues/peer interventions, and individual‐centered interventions. Findings showed that more health and well‐being intervention research tailored to the needs of CWW is needed within the field.
Real‐world evidence of avatrombopag for the treatment of immune thrombocytopenia intolerant or ineffective to eltrombopag/hetrombopag
Authors: Tian Hong , Zhou Lu , Dai Jia‐wen , Li Yun , Gu Cheng‐Yuan , Kong Dan‐Qing , Yu Zi‐Qiang , Liu Xiao‐fan , Yin Jie 
Published: October 2024

SummaryDue to the limited real‐world research on the application of avatrombopag (AVA) for immune thrombocytopenia (ITP) in China, we evaluated the effectiveness and safety of AVA in clinical practice. We included 121 adult ITP patients treated with AVA across three medical centres. Based on the reasons for choosing AVA, these patients were divided into eltrombopag (ELT)/hetrombopag (HET) intolerance group (IG), and ELT/HET unresponsive group (UG). Compared with UG, more patients in IG had a history of liver disease and received fewer treatments before AVA. Amongst all patients, 83% had platelet response (≥30 × 109/L) after AVA and 62% achieved complete response (≥100 × 109/L, CR). Sixty‐two percent in IG and 56% in UG were able to discontinue more than one concomitant ITP medication. A total of 17 patients underwent multiple switches of thrombopoietin receptor agonists (TPO‐RAs), resulting in an 88% platelet response rate. Sixty‐three patients discontinued AVA, 27% were due to unaffordability. AVA was well tolerated in most patients. In the ITP population, AVA proved effective and safe, particularly in patients intolerant or unresponsive to ELT/HET. Patients benefited from TPO‐RAs switches, particularly those undergoing multiple switches. However, many patients struggled with the long‐term financial burden of AVA.
Orthographic character complexity modulates dynamic neural activity in skilled handwriting
Authors: Pei Leisi , Sommer Werner , Ouyang Guang 
Published: October 2024

AbstractHandwriting is an outstanding case of a highly complex and efficient fine motor skill. However, little is known about its neural underpinnings during continuous handwriting production. In the present study, we examined the effects of orthographic character complexity (i.e. the stroke number of a Chinese character) on both neural and behavioural activities during an EEG‐based naturalistic fluent sentence‐handwriting task from 102 adult Chinese native speakers. For each written character, the interval between finishing the preceding character and its onset (inter‐character interval) as well as the amplitudes of the onset‐synchronized event‐related potential (ERP) in pre‐ and post‐onset time windows was defined as dependent variables. The effects of character complexity and other confounding factors were analysed with linear mixed models. Character complexity increased the inter‐character interval and significantly affected ERP amplitudes in both pre‐ and post‐onset time windows. The ERP pattern in the pre‐event time window exhibited a dipole‐like activation in the left motor cortex, and its amplitude increased with character complexity in line with the documented relationship between the lateralized readiness potential and motor complexity. This study demonstrates the feasibility of studying neurocognitive processes in complex naturalistic motor tasks and extends our knowledge about the dynamic pattern of handwriting‐related neural activities.
In vitro and in vivo study of butyrylfentanyl and 4‐fluorobutyrylfentanyl in female and male mice: Role of the CRF1 receptor in cardiorespiratory impairment
Authors: Bilel Sabrine , Azevedo Neto Joaquim , Tirri Micaela , Corli Giorgia , Bassi Marta , Fantinati Anna , Serpelloni Giovanni , Malfacini Davide , Trapella Claudio , Calo' Girolamo , Marti Matteo 
Published: October 2024

AbstractBackground and PurposeFentanyl analogues have been implicated in many cases of intoxication and death with overdose worldwide. The aim of this study is to investigate the pharmaco‐toxicology of two fentanyl analogues: butyrylfentanyl (BUF) and 4‐fluorobutyrylfentanyl (4F‐BUF).Experimental ApproachIn vitro, we measured agonist opioid receptor efficacy, potency, and selectivity and ability to promote interaction of the μ receptor with G protein and β‐arrestin 2. In vivo, we evaluated thermal antinociception, stimulated motor activity and cardiorespiratory changes in female and male CD‐1 mice injected with BUF or 4F‐BUF (0.1–6 mg·kg−1). Opioid receptor specificity was investigated using naloxone (6 mg·kg−1). We investigated the possible role of stress in increasing cardiorespiratory toxicity using the corticotropin‐releasing factor 1 (CRF1) antagonist antalarmin (10 mg·kg−1).Key ResultsAgonists displayed the following rank of potency at μ receptors: fentanyl > 4F‐BUF > BUF. Fentanyl and BUF behaved as partial agonists for the β‐arrestin 2 pathway, whereas 4F‐BUF did not promote β‐arrestin 2 recruitment. In vivo, we revealed sex differences in motor and cardiorespiratory impairments but not antinociception induced by BUF and 4F‐BUF. Antalarmin alone was effective in blocking respiratory impairment induced by BUF in both sexes but not 4F‐BUF. The combination of naloxone and antalarmin significantly enhanced naloxone reversal of the cardiorespiratory impairments induced by BUF and 4F‐BUF in mice.Conclusion and ImplicationsIn this study, we have uncovered a novel mechanism by which synthetic opioids induce respiratory depression, shedding new light on the role of CRF1 receptors in cardiorespiratory impairments by μ agonists.
Anti‐inflammatory and remyelinating effects of fexagratinib in experimental multiple sclerosis
Authors: Gurski Fynn , Shirvanchi Kian , Rajendran Vinothkumar , Rajendran Ranjithkumar , Megalofonou Fevronia‐Foivi , Böttiger Gregor , Stadelmann Christine , Bhushan Sudhanshu , Ergün Süleyman , Karnati Srikanth , Berghoff Martin 
Published: October 2024

AbstractBackground and PurposeFGF, VEGFR‐2 and CSF1R signalling pathways play a key role in the pathogenesis of multiple sclerosis (MS). Selective inhibition of FGFR by infigratinib in MOG35‐55‐induced experimental autoimmune encephalomyelitis (EAE) prevented severe first clinical episodes by 40%; inflammation and neurodegeneration were reduced, and remyelination was enhanced. Multi‐kinase inhibition of FGFR1‐3, CSFR and VEGFR‐2 by fexagratinib (formerly known as AZD4547) may be more efficient in reducing inflammation, neurodegeneration and regeneration in the disease model.Experimental ApproachFemale C57BL/6J mice were treated with fexagratinib (6.25 or 12.5 mg·kg−1) orally or placebo over 10 days either from time of EAE induction (prevention experiment) or onset of symptoms (suppression experiment). Effects on inflammation, neurodegeneration and remyelination were assessed at the peak of the disease (Day 18/20 post immunization) and the chronic phase of EAE (Day 41/42).Key ResultsIn the prevention experiment, treatment with 6.25 or 12.5 mg·kg−1 fexagratinib prevented severe first clinical episodes by 66.7% or 84.6% respectively. Mice treated with 12.5 mg·kg−1 fexagratinib hardly showed any symptoms in the chronic phase of EAE. In the suppression experiment, fexagratinib resulted in a long‐lasting reduction of severe symptoms by 91 or 100%. Inflammation and demyelination were reduced, and axonal density, numbers of oligodendrocytes and their precursor cells, and remyelinated axons were increased by both experimental approaches.Conclusion and ImplicationsMulti‐kinase inhibition by fexagratinib in a well‐tolerated dose of 1 mg·kg−1 in humans may be a promising approach to reduce inflammation and neurodegeneration, to slow down disease progression and support remyelination in patients.
The first in‐human study to evaluate the antiplatelet properties of the clopidogrel conjugate DT‐678 in acute coronary syndrome patients and healthy volunteers
Authors: Liu Zhihao , Liu Shengcong , Gong Yanjun , Chi Xiying , Wang Ting , Fan Fangfang , Qu Chenxue , Lou Yaxin , Zhang Long , Zhang Bin , Yang Fan , Mohetaboer Momin , Wang Jie , Qiu Lin , Miao Linzi , Lu Yao , You Ran , He Pengkang , Li Yuxi , Yi Tieci , Weng Haoyu , Xia Yulong , Wang Chunyan , Shi Qiuping , Wang Zhi , Jiang Yimeng , Li Yinjuan , Han Chunyu , Wang Yu , Wang Xinghe , Yang Caixia , Chen Y. Eugene , Eitzman Daniel T. , Zhang Haoming , Li Jianping 
Published: October 2024

Background and PurposeDT‐678 is a novel antiplatelet prodrug, capable of releasing the antiplatelet active metabolite of clopidogrel (AM) upon exposure to glutathione. In this study, we investigated factors responsible for clopidogrel high on‐treatment platelet reactivity (HTPR) in acute coronary syndrome (ACS) patients and evaluated the capacity of DT‐678 to overcome HTPR.Experimental ApproachA total of 300 consecutive ACS patients naive to P2Y12 receptor inhibitors were recruited and genotyped for CYP2C19 alleles. Blood samples were drawn before and after administration of 600‐mg clopidogrel. Platelet reactivity index (PRI) and plasma AM concentrations were determined and grouped according to their CYP2C19 genotypes. DT‐678 was applied ex vivo to whole blood samples to examine its inhibitory effects. To further examine the antiplatelet effectiveness of DT‐678 in vivo, 20 healthy human subjects were recruited in a Phase I clinical trial, and each received a single dose of either 3‐mg DT‐678 or 75‐mg clopidogrel. The pharmacokinetics and pharmacodynamics in different CYP2C19 genotype groups were compared.Key ResultsStatistical analyses revealed that CYP2C19 genotype, body mass index, hyperuricaemia, and baseline PRI were significantly associated with a higher risk of clopidogrel HTPR in ACS patients. The addition of DT‐678 ex vivo decreased baseline PRI regardless of CYP2C19 genotypes, overcoming clopidogrel HTPR. This observation was further confirmed in healthy volunteers receiving 3 mg of DT‐678.Conclusion and ImplicationsThese results suggest that DT‐678 effectively overcomes clopidogrel HTPR resulting from genetic and/or clinical factors in Chinese ACS patients, demonstrating its potential to improve antiplatelet therapy.