bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Situ Electrochemical Evolution of Amorphous Metallic Borides Enabling Long Cycling Room‐/Subzero‐Temperature Sodium‐Sulfur Batteries
Authors: Wang Bin , Wang Lu , Guo Beining , Kong Yueyue , Wang Fengbo , Jing Zhongxin , Qu Guangmeng , Mamoor Muhammad , Wang Dedong , He Xiyu , Kong Lingtong , Xu Liqiang 
Published: October 2024

AbstractRoom temperature sodium‐sulfur batteries (RT Na‐S) have garnered significant attention for their high energy density and cost‐effectiveness, positioning them as a promising alternative to lithium‐ion batteries. However, they encounter challenges such as the dissolution of sodium polysulfides and sluggish kinetics. Introducing high‐activity electrocatalysts and enhancing the density of active sites represents an efficient strategy to enhance reaction kinetics. Here, an amorphous Ni‐B material that undergoes electrochemical evolution to generate the NiSx phase within an operational sodium‐sulfur battery, contrasting with the crystalline NiB counterpart is fabricated. Electrochemical cycling facilitated the establishment of an interface between the amorphous Ni‐B and NiSx, leading to heightened catalytic activity and improved reaction kinetics. Consequently, batteries utilizing the amorphous Ni‐B showcased a notable initial specific capacity of 1487 mAh g−1 at 0.2 A g−1, exhibiting exceptional performance under high current densities of 5 A g−1, in low‐temperature conditions (−10 °C), with high sulfur loading, and in pouch cell configurations.
Visible Light Active 0.95KNbO3‐0.05Ba(Nb1/2Sc1/2)O3 Ferroelectric for Enhanced Photocatalytic Activity
Authors: Takhar Devender , Chahar Ankit , Sharama Deepanshu , Ghosh Ram Krishna , Birajdar Balaji 
Published: October 2024

AbstractThis study reports a visible light active Ba/Sc co‐doped potassium niobate (KNbO3) ferroelectric material for enhanced photocatalytic applications. Through 5% Ba and Sc co‐doping in KNbO3 (i.e., 0.95KNbO3‐0.05Ba(Nb1/2Sc1/2)O3), the electronic band gap (Eg) is narrowed down to the visible range of the solar spectrum. The prepared samples are systematically examined by using X‐ray diffraction and Raman spectroscopy, which confirms the successful incorporation of Ba and Sc ions into the KNbO3 lattice. Scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) analysis reveal particle morphology and chemical homogeneity of prepared samples. The UV–vis spectroscopy and ferroelectric PE‐loop demonstrate enhanced optical absorption compared to host KNbO3 while retaining ferroelectric behavior. The photoelectrochemical (PEC) measurements under visible light irradiation demonstrate a notable enhancement in the photocurrent for 0.95KNbO3‐0.05Ba(Nb1/2Sc1/2)O3 (hereafter denoted by 5KBSNO) compared to undoped KNbO3. Additionally, the 5KBSNO sample displays enhanced RhB dye degradation efficiency, reaching ≈50% compared to parent KNbO3 (≈30%) under light irradiation. First‐principles density functional theory (DFT) calculations are employed to understand the mechanism responsible for the reduced band gap. This study presents a promising material for developing advanced ferroelectric photocatalysts with tailored band structures for efficient solar energy harvesting for energy conversion and contamination remediation applications.
Tailoring of Time for Hydrothermal Synthesis of 2D MoSe2 with Enhanced Adsorption and Electro‐Catalytic Efficiency for Applications in Self‐Cleaning and Hydrogen Energy Generation
Authors: Layek Rashbihari , Kumbhakar Pathik 
Published: October 2024

AbstractMolybdenum diselenide (MoSe2), a 2D layered transition metal dichalcogenide, has garnered significant scientific research interest for its catalytic and electrocatalytic activities. Here, a straightforward hydrothermal procedure is used to synthesize MoSe2 nanosheets (NSs) and focus on their adsorption capabilities and hydrogen evolution reaction (HER) activity. The MoSe2 NSs which are synthesized by 12 h of hydrothermal treatment found to exhibit the highest adsorption capacity of 91.67 mg g−1. The kinetics of the adsorption process have been found to follow the pseudo‐second‐order model, signifying chemisorption and multilayer adsorption as described by the Freundlich isotherm. The thermodynamic analysis further suggests that the adsorption proceeds by endothermic and spontaneous mechanisms. The self‐cleaning property of the adsorbent is demonstrated by degrading the dye on the adsorbent‐coated cotton fabric. The sample created using a 12 h hydrothermal method has been shown to have a minimal Tafel slope of 58 mV dec−1. It also shows excellent HER activity at low over‐potential and possesses long‐term durability. The dual functionality of MoSe2 NSs in both adsorption and electrocatalytic activity highlights their potential for application in environmental remediation and renewable energy production.
CDC7 Inhibition Potentiates Antitumor Efficacy of PARP Inhibitor in Advanced Ovarian Cancer
Authors: Liu Shini , Deng Peng , Yu Zhaoliang , Hong Jing Han , Gao Jiuping , Huang Yulin , Xiao Rong , Yin Jiaxin , Zeng Xian , Sun Yichen , Wang Peili , Geng Ruizi , Chan Jason Yongsheng , Guan Peiyong , Yu Qiang , Teh Bin‐Tean , Jiang Qingping , Xia Xiaojun , Xiong Ying , Chen Jianfeng , Huo Yongliang , Tan Jing 
Published: October 2024

AbstractPoly (ADP‐ribose) Polymerase inhibitors (PARPi) have demonstrated remarkable clinical efficacy in treating ovarian cancer (OV) with BRCA1/2 mutations. However, drug resistance inevitably limits their clinical applications and there is an urgent need for improved therapeutic strategies to enhance the clinical utility of PARPi, such as Olaparib. Here, compelling evidence indicates that sensitivity of PARPi is associated with cell cycle dysfunction. Through high‐throughput drug screening with a cell cycle kinase inhibitor library, XL413, a potent cell division cycle 7 (CDC7) inhibitor, is identified which can synergistically enhance the anti‐tumor efficacy of Olaparib. Mechanistically, the combined administration of XL413 and Olaparib demonstrates considerable DNA damage and DNA replication stress, leading to increased sensitivity to Olaparib. Additionally, a robust type‐I interferon response is triggered through the induction of the cGAS/STING signaling pathway. Using murine syngeneic tumor models, the combination treatment further demonstrates enhanced antitumor immunity, resulting in tumor regression. Collectively, this study presents an effective treatment strategy for patients with advanced OV by combining CDC7 inhibitors (CDC7i) and PARPi, offering a promising therapeutic approach for patients with limited response to PARPi.
Programmed BRD9 Degradation and Hedgehog Signaling Activation via Silk‐Based Core‐Shell Microneedles Promote Diabetic Wound Healing
Authors: Liu Yili , Zhou Mingliang , Sun Jinrui , Yao Enhui , Xu Jingyi , Yang Guangzheng , Wu Xiaolin , Xu Ling , Du Jiahui , Jiang Xinquan 
Published: October 2024

AbstractWound healing impairment in diabetes mellitus is associated with an excessive inflammatory response and defective regeneration capability with suppressed Hedgehog (Hh) signaling. The bromodomain protein BRD9, a subunit of the non‐canonical BAF chromatin‐remodeling complex, is critical for macrophage inflammatory response. However, whether the epigenetic drug BRD9 degrader can attenuate the sustained inflammatory state of wounds in diabetes remains unclear. Without a bona fide immune microenvironment, Hh signaling activation fails to effectively rescue the suppressed proliferative ability of dermal fibroblasts and the vascularization of endothelial cells. Therefore, a silk‐based core‐shell microneedle (MN) patch is proposed to dynamically modulate the wound immune microenvironment and the regeneration process. Specifically, the BRD9 degrader released from the shell of the MNs mitigated the excessive inflammatory response in the early phase. Subsequently, the positively charged Hh signaling agonist is released from the negatively charged core of the silk fibroin nanofibers and promotes the phase transition from inflammation to regeneration, including re‐epithelialization, collagen deposition, and angiogenesis. These findings suggest that the programmed silk‐based core‐shell MN patch is an ideal therapeutic strategy for effective skin regeneration in diabetic wounds.
EIF4A3‐Induced Circular RNA CircDdb1 Promotes Muscle Atrophy through Encoding a Novel Protein CircDdb1‐867aa
Authors: Zhu Xiaolan , Yang Tingting , Zheng Yongjun , Nie Qiumeng , Chen Jingying , Li Qian , Ren Xinyi , Yin Xiaohang , Wang Siqi , Yan Yuwei , Liu Zhengyu , Wu Ming , Lu Dongchao , Yu Yan , Chen Lei , Chatterjee Emeli , Li Guoping , Cretoiu Dragos , Bowen T Scott , Li Jin , Xiao Junjie 
Published: October 2024

AbstractLittle is known about if and how circular RNAs (circRNAs) are involved in skeletal muscle atrophy. Here a conserved circular RNA Damage‐specific DNA binding protein 1 (circDdb1), derived from the host gene encoding Damage‐specific DNA binding protein 1 (DDB1), as a mechanism of muscle atrophy is identified. circDdb1 expression is markedly increased in a variety of muscle atrophy types in vivo and in vitro, and human aging muscle. Both in vivo and in vitro, ectopic expression of circDdb1 causes muscle atrophy. In contrast, multiple forms of muscle atrophy caused by dexamethasone, tumor necrosis factor‐alpha (TNF‐α), or angiotensin II (Ang II) in myotube cells, as well as by denervation, angiotensin II, and immobility in mice, are prevented by circDdb1 inhibition. Eukaryotic initiation factor 4A3 (EIF4A3) is identified as a regulator of circDdb1 expression in muscle atrophy, whereas circDdb1 encodes a novel protein, circDdb1‐867aa. circDdb1‐867aa binds with and increases the phosphorylation level of eukaryotic elongation factor 2 (eEF2) at Thr56 to reduce protein translation and promote muscle atrophy. In summary, these findings establish circDdb1 as a shared regulator of muscle atrophy across multiple diseases and a potential therapeutic target.
Metal Ruthenium Complexes Treat Spinal Cord Injury By Alleviating Oxidative Stress Through Interaction With Antioxidant 1 Copper Chaperone Protein
Authors: Li Juanjuan , Peng Cheng , Huang Caiqiang , Wan Li , Wang Ke , Wu Ping , Chen Tianjun , Sun Guodong , Guo Rui , Lin Hongsheng , Ji Zhisheng 
Published: October 2024

AbstractOxidative stress is a major factor affecting spinal cord injury (SCI) prognosis. A ruthenium metal complex can aid in treating SCI by scavenging reactive oxygen species via a protein‐regulated mechanism to alleviate oxidative stress. This study aimed to introduce a pioneering strategy for SCI treatment by designing two novel half‐sandwich ruthenium (II) complexes containing diverse N^N‐chelating ligands. The general formula is [(η6‐Arene)Ru(N^N)Cl]PF6, where arene is either 2‐phenylethanol‐1‐ol (bz‐EA) or 3‐phenylpropanol‐1‐ol (bz‐PA), and the N^N‐chelating ligands are fluorine‐based imino‐pyridyl ligands. This study shows that these ruthenium metal complexes protect neurons by scavenging reactive oxygen species. Notably, η6‐Arene substitution from bz‐PA to bz‐EA significantly enhances reactive oxygen species scavenging ability and neuroprotective effect. Additionally, molecular dynamics simulations indicate that the ruthenium metal complex increases Antioxidant 1 Copper Chaperone protein expression, reduces oxidative stress, and protects neurons during SCI treatment. Furthermore, ruthenium metal complex protected spinal cord neurons and stimulated their regeneration, which improves electrical signals and motor functions in mice with SCI. Thus, this treatment strategy using ruthenium metal complexes can be a new therapeutic approach for the efficient treatment of SCI.
Enhanced Ferroelectric Polarization in Au@BaTiO3 Yolk‐in‐Shell Nanostructure for Synergistic Boosting Visible‐Light‐ Piezocatalytic CO2 Reduction
Authors: Hu Jun , Zhao Rufang , Ni Jingren , Luo Wei , Yu Hongjian , Huang Hongwei , Wu Boyuan , Wang Yang , Han Jie , Guo Rong 
Published: October 2024

AbstractDeveloping efficient photo‐piezocatalytic systems to achieve the conversion of renewable energy to chemical energy emerges enormous potential. However, poor catalytic efficiency remains a significant obstacle to future practical applications. Herein, a series of unique Au@BaTiO3 (Au@BT) yolk‐shell nanostructure photo‐piezocatalyst is constructed with single Au nanoparticle (Au NP) embedded in different positions within ferroelectric BaTiO3 hollow nanosphere (BT‐HNS). This special structure showcases excellent mechanical force sensitivity and provides ample plasmon‐induced interfacial charge‐transfer pathways. In addition, the powerful piezoelectric polarization electric field induced by the enhanced ferroelectric polarization electric field via corona poling treatment in BT‐HNS further promotes charge separation, CO2 adsorption and key intermediate conversion. Notably, BT with single Au NP encapsulated into hollow nanosphere shell with reinforced polarization (Au@BT‐1‐P) shows synergistically improved photo‐piezocatalytic CO2 reduction activity for producing CO with a high production rate of 31.29 µmol g−1 h−1 under visible light irradiation and ultrasonic vibration. This work highlights a generic tactic for optimized design of high‐performance and multifunctional nanostructured photo‐piezocatalyst. Meanwhile, these yolk‐in‐shell nanostructures with single Au nanoparticle as an ideal model may hold great promise to inspire in‐depth exploration of carrier dynamics and mechanistic understanding of the catalytic reaction.
Seasonal Feeding Activity and Ontogenetic Dietary Shifts of the Common Carp (Cyprinus carpio) in Lake Arekit, a Small, Eutrophic Lake in Ethiopia
Authors: Wagaw Solomon , Enawgaw Yirga , Wendimu Injigu , Weldemichael Helen 
Published: October 2024

ABSTRACTSeasonal feeding activity and ontogenetic dietary shifts of Cyprinus carpio (Linnaeus, 1758) were examined using 209 fish samples from Lake Arekit, Ethiopia. Among the 209 specimens, 174 (83.3%) displayed a range of dietary items in their stomachs. The species’ feeding patterns were determined through numerical indexes (frequency of occurrence and volumetric contribution) and composite indexes (index of preponderance [IOP] and Geometric Index of Importance [GIIi]). Detritus emerged as the primary food source for C. carpio, followed by macrophytes, insects and zooplankton. A lesser amount of phytoplankton, nematodes and ostracods were also consumed. On the basis of the findings, C. carpio can be classified as a detri‐omnivore, as it consumes benthic species like nematodes, ostracods and insect larvae. Seasonal fluctuations in food item consumption were noted (p < 0.05), with higher intake during the rainy season and reduced consumption in the dry season. There was a distinct ontogenetic shift in the relative importance of food items and showed significant variations in food preferences among size groups (p < 0.05). The contributions of animal‐origin food categories (ostracods, zooplankton and insects) were important in the diet of the smaller size class, whereas food of plant origin (macrophytes) and detritus were more important in the diet of adults. Understanding the seasonal feeding patterns and ontogenetic dietary shifts of C. carpio in Lake Arekit provides crucial insights into their ecological role within the lake's ecosystem and highlights their adaptability to eutrophic conditions.
Ethers as Building Blocks for the Synthesis and Modification of N‐Heterocycles
Authors: Grishin Sergey S. , Mulina Olga M. , Lv Leiyang , Vil Vera A. , Li Zhiping , Terent'ev Alexander O. 
Published: October 2024

AbstractThe use of C−H compounds as reactive partners in a variety of transformations represents the state of the art in synthetic methodology. In this review, we have summarized the main achievements in using ethers as building blocks for the construction and modification of one of the basic platforms of organic chemistry, nitrogen‐containing heterocycles. Ethers, previously considered mainly as solvents, are excellent CH‐partners, capable of generating radical or cationic reactive species under the action of HAT agents and oxidants. The challenge in this field is the still limited number of heterocyclic systems and other starting reagents, with which the processes can be carried out selectively due to closer bond dissociation energies and oxidation potentials of heterocycles, reactive intermediates and ethers. However, the fine‐tuning of the reaction system using electro‐ and photochemical approaches and a deep understanding of the reaction pathways make the use of ethers as C−H reagents a promising synthetic strategy.
Artificial intelligence–assisted oculo‐gait measurements for cognitive impairment in cerebral small vessel disease
Authors: Chen Huimin , Du Hao , Yi Fang , Wang Tingting , Yang Shuo , Pan Yuesong , Yan Hongyi , Liu Dandan , Zhou Mengyuan , Chen Yiyi , Zhao Mengxi , Pi Jingtao , Yang Yingying , Fan Xiangmin , Cai Xueli , Qiu Ziyu , Zhang Jipeng , Liu Yawei , Gu Wenping , Wang Yilong 
Published: October 2024

AbstractINTRODUCTIONOculomotor and gait dysfunctions are closely associated with cognition. However, oculo‐gait patterns and their correlation with cognition in cerebral small vessel disease (CSVD) remain unclear.METHODSPatients with CSVD from a hospital‐based cohort (n = 194) and individuals with presumed early CSVD from a community‐based cohort (n = 319) were included. Oculo‐gait patterns were measured using the artificial intelligence (AI) –assisted ‘EyeKnow’ eye‐tracking and ‘ReadyGo’ motor evaluation systems. Multivariable linear and logistic regression models were employed to investigate the association between the oculo‐gait parameters and cognition.RESULTSAnti‐saccade accuracy, stride velocity, and swing velocity were significantly associated with cognition in both patients and community dwellers with CSVD, and could identify cognitive impairment in CSVD with moderate accuracy (area under the curve [AUC]: hospital cohort, 0.787; community cohort, 0.810) after adjusting for age and education.DISCUSSIONThe evaluation of oculo‐gait features (anti‐saccade accuracy, stride velocity, and swing velocity) may help screen cognitive impairment in CSVD.Highlights
Oculo‐gait features (lower anti‐saccade accuracy, stride velocity, and swing velocity) were associated with cognitive impairment in cerebral small vessel disease (CSVD).
Logistic model integrating the oculo‐gait features, age, and education level moderately distinguished cognitive status in CSVD.
Artificial intelligence–assisted oculomotor and gait measurements provide quick and accurate evaluation in hospital and community settings.
Li2MoO4 Tailored Anion‐enhanced Solvation Sheath Layer Promotes Solution‐phase Mediated Li‐O2 Batteries
Authors: Zhang Fengling , Hu Zhengqiang , Lai Jingning , Faiza Arshad , Hu Xin , Sun Wen , Zhou Anbin , Wang Huirong , Chen Yi , Xue Tianyang , Ye Yusheng , Chen Nan , Li Li , Wu Feng , Chen Renjie 
Published: October 2024

AbstractThe high overpotential of Li‐O2 batteries (LOBs) is primarily triggered by sluggish charge transfer kinetics at the reaction interfaces. A typical LiBr redox mediator (RM) catalyst can effectively reduce the battery's overpotential. However, it is prone to shuttling and corroding the Li anode, leading to RM loss and reduced energy efficiency. To address these challenges, we introduced Li2MoO4 into the LiBr‐containing electrolyte to promote the solution‐phase mediated LOBs. This addition tailors the anion‐enhanced Li+ solvation sheath layer and forms a robust anion‐derived solid electrolyte interphases (SEI) on the Li anode. The robust SEI effectively mitigates the corrosion of soluble Br3−/Br2 and attacks by highly reactive oxygen species. Additionally, the dispersed and high‐density Li2MoO4 exhibits strong adsorption capabilities for O2/LiO2 and Br‐related species during the discharge/charge process, thereby promoting the growth and decomposition of Li2O2 in the solution phase and inhibiting the shuttle effect of Br‐related species in LOBs. Consequently, the LOBs demonstrate exceptional cycling stability (415 cycles) and high energy efficiency (86.2 %), paving the way for the sustainable development and practical application of these battery systems.
Organic Room Temperature Phosphorescence from BN‐Substituted Xanthene Derivatives
Authors: Watson Alexander E. R. , Tao Si Yuan , Siemiarczuk Alex , Boyle Paul D. , Ragogna Paul J. , Gilroy Joe B. 
Published: October 2024

AbstractEmissive organic materials are predominantly fluorescent and there is significant interest in realizing and understanding examples that defy this paradigm and exhibit phosphorescence under ambient conditions. Organic room temperature phosphorescence (ORTP) offers the long‐lived excited states and bathochromically‐shifted emission maxima of phosphorescence without the use of potentially toxic and expensive transition metals. Most ORTP materials rely on well‐studied structural motifs that include aryl carbonyls, sulfones, and heavy main group elements. We report the unexpected ORTP of a series of heavy atom‐free BN‐substituted xanthene derivatives. The creation of heteroatom‐rich scaffolds, combined with stabilizing C−H⋅⋅⋅F interactions in the solid‐state, resulted in oxygen‐tolerant heavy atom‐free organic phosphorescence without relying on the use of cryogenic temperatures, polymer matrices, or host–guest interactions. The observation of ORTP in these simple systems sets a blueprint for the further development of heavy atom‐free organic phosphors.
Oxygen Plasma Triggered Co−O−Fe Motif in Prussian Blue Analogue for Efficient and Robust Alkaline Water Oxidation
Authors: Guan Xu Hao , Zhu Chen , Yang Lin Hao , Kai Liu Ji , Xiao Wu Yi , Qin Fu Huai , Yu Zhang Xin , Mao Fangxin , Yang Yuan Hai , Sun Chenghua , Fei Liu Peng , Gui Yang Hua 
Published: October 2024

AbstractIn the context of oxygen evolution reaction (OER), the construction of high‐valence transition metal sites to trigger the lattice oxygen oxidation mechanism is considered crucial for overcoming the performance limitations of traditional adsorbate evolution mechanism. However, the dynamic evolution of lattice oxygen during the reaction poses significant challenges for the stability of high‐valence metal sites, particularly in high‐current‐density water‐splitting systems. Here, we have successfully constructed Co−O−Fe catalytic active motifs in cobalt‐iron Prussian blue analogs (CoFe‐PBA) through oxygen plasma bombardment, effectively activating lattice oxygen reactivity while sustaining robust stability. Our spectroscopic and theoretical studies reveal that the Co−O−Fe bridged motifs enable a unique double‐exchange interaction between Co and Fe atoms, promoting the formation of high‐valence Co species as OER active centers while maintaining Fe in a low‐valence state, preventing its dissolution. The resultant catalyst (CoFe‐PBA‐30) requires an overpotential of only 276 mV to achieve 1000 mA cm−2. Furthermore, the assembled alkaline exchange membrane electrolyzer using CoFe‐PBA‐30 as anode material achieves a high current density of 1 A cm−2 at 1.76 V and continuously operates for 250 hours with negligible degradation. This work provides significant insights for activating lattice oxygen redox without compromising structure stability in practical water electrolyzers.