bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreatic α-cell hyperplasia and hyperglucagonemia due to a glucagon receptor splice mutation
Authors: Larger Etienne , Wewer Albrechtsen Nicolai J , Hansen Lars H , Gelling Richard W , Capeau Jacqueline , Deacon Carolyn F , Madsen Ole D , Yakushiji Fumiatsu , De Meyts Pierre , Holst Jens J , Nishimura Erica 
Published: November 2016

SummaryGlucagon stimulates hepatic glucose production by activating specific glucagon receptors in the liver, which in turn increase hepatic glycogenolysis as well as gluconeogenesis and ureagenesis from amino acids. Conversely, glucagon secretion is regulated by concentrations of glucose and amino acids. Disruption of glucagon signaling in rodents results in grossly elevated circulating glucagon levels but no hypoglycemia. Here, we describe a patient carrying a homozygous G to A substitution in the invariant AG dinucleotide found in a 3′ mRNA splice junction of the glucagon receptor gene. Loss of the splice site acceptor consensus sequence results in the deletion of 70 nucleotides encoded by exon 9, which introduces a frame shift and an early termination signal in the receptor mRNA sequence. The mutated receptor neither bound125I-labeled glucagon nor induced cAMP production upon stimulation with up to 1 µM glucagon. Despite the mutation, the only obvious pathophysiological trait was hyperglucagonemia, hyperaminoacidemia and massive hyperplasia of the pancreatic α-cells assessed by histology. Our case supports the notion of a hepato–pancreatic feedback system, which upon disruption leads to hyperglucagonemia and α-cell hyperplasia, as well as elevated plasma amino acid levels. Together with the glucagon-induced hypoaminoacidemia in glucagonoma patients, our case supports recent suggestions that amino acids may provide the feedback link between the liver and the pancreatic α-cells.Learning points:Loss of function of the glucagon receptor may not necessarily lead to the dysregulation of glucose homeostasis.Loss of function of the glucagon receptor causes hyperaminoacidemia, hyperglucagonemia and α-cell hyperplasia and sometimes other pancreatic abnormalities.A hepato–pancreatic feedback regulation of the α-cells, possibly involving amino acids, may exist in humans.
Internal consistency, convergent validity, and structural validity of the Japanese version of the Physical Activity Self-Regulation scale (PASR-12) among Japanese workers: A validation study
Authors: Watanabe Kazuhiro , Kawakami Norito , Adachi Hidehiko , Inoue Shigeru , Meyer M Renee Umstattd 
Published: November 2016

Abstract

Objectives
Self-regulation for physical activity is considered as one of the most effective factors in promoting physical activity. However, there is no reliable and valid scale to measure it in Japanese. The purpose of this study was to investigate the internal consistency, convergent validity, and structural validity of the newly developed Japanese version of the 12-item Physical Activity Self-Regulation scale (PASR-12) among Japanese workers.

Methods
A cross-sectional Internet-based survey recruiting 516 Japanese workers was conducted in Japan. The PASR-12 was translated according to the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) task force guidelines. Physical activity and self-efficacy for physical activity were measured as comparisons for convergent validity. We calculated Cronbach’s alphas, and conducted correlational analyses and confirmatory factor analysis (CFA) .

Results
Of 516 workers, 485 workers were eligible for all analyses. Cronbach’s alpha for the scale scores ranged from 0.79 to 0.95. The scores of the total and 6 factor scales of the Japanese version of the PASR-12 had small-to-moderate positive correlations with the total physical activity and self-efficacy. Moreover, the 6-factor hypothesized model demonstrated excellent fit (χ2 (39) = 100.74, CFI = 0.973, RMSEA = 0.057).

Conclusions
The Japanese version of the PASR-12 showed good reliability and factor-based and construct validity. Therefore, this scale could be applied to assess self-regulation for physical activity among Japanese workers.
Insecta, Coleoptera, Buprestidae, Buprestis langii Mannerheim, 1843: distribution extension
Authors: De Jong Grant D. , Chadwick James W. 
Published: November 2016

The wood-boring beetle Buprestis langii Mannerheim, 1843 has a widespread distribution in the northwestern Neartic region. Here we report the collection of one adult female of this species in the town of Watson Lake, Yukon Territory, Canada, thus representing a new territorial record for B. langii.
PENGOPERASIAN PANCING RAWAI TUNA (TUNA LONGLINE) DI SAMUDERA HINDIA
Authors: Rahmat Enjah 
Published: November 2016

Perairan Samudera Hindia yang membentang dari barat Sumatera sampai selatan Bali dan Nusa Tenggara adalah salah satu daerah penangkapan ikan bagi nelayan-nelayan di Indonesia. Tercatat ada empat pelabuhan yang cukup besar di Indonesia yang secara geografis menghadap ke perairan Samudera Hindia,yaitu Pelabuhan Ratu, Cilacap, Prigi (Jawa), dan Benoa (Bali). Jenis-jenis alat tangkap ikan yang digunakan nelayan Indonesia di perairan SamuderaHindia antara lain pancing rawai tuna (tuna longline), pancing tangan (hand line), jaring insang hanyut (drift gillnet), dan jaring lingkar (purse seine). Adapun jenis jenis ikan yang tertangkap terdiri atas jenis-jenis ikan pelagis besar, pelagis kecil, dan demersal.
PENANGKAPAN IKAN MENGGUNAKAN JARING INSANG DI WADUK IR. H. DJUANDA, JATILUHUR
Authors: Sumarno Dedi , Sukamto Sukamto 
Published: November 2016

Waduk Ir. H. Djuanda terletak di Kabupaten Purwakarta-Jawa Barat, merupakan suatu badan air yang membendung Sungai Citarum, yang beroperasi sejak tahun 1967. Waduk Ir. H. Djuanda mempunyai luas 8.300 ha dan merupakan waduk serba guna di antaranya bermanfaat untuk pembangkit listrik tenaga air, penyediaan baku air minum dan industri, irigasi, perikanan, pariwisata, dan pengendalian banjir (Sudjana, 2004).Sesuai dengan manfaat waduk Ir. H. Djuanda di bidang perikanan, pada umumnya nelayan menangkap ikan menggunakan alat pancing, jaringtebar, dan jaring insang. Alat tangkap yang dominan diWaduk Ir. H. Djuanda adalah jaring insang dengan ukuran mata jaring kurang dari 2 inci sehinggadiperoleh hasil tangkapan ikan yang berukuran kecil atau anak-anak ikan. Hal ini akan berakibat terputusnya siklus hidup ikan. Mekanisme jaring insang didasarkan atas tertangkap ikan di bagian insangnya, jaring insang merupakan salah satu alat tangkap ikan yang bersifat pasif, ikan yang tertangkap adalah ikan yangmelewati jaring insang. Jaring insangdioperasikan dengan metode mirip dengan pagar jaring, untuk membentuk tegaknya jaring digunakan pelampung dan pemberat (Surur, 2004).
PENGOPERASIAN KAPAL PUKAT CINCIN MEDIUM DI PANIMBANG DAN SIDAMUKTI
Authors: Salim Agus 
Published: November 2016

Sejak diperkenalkan alat tangkap pukat cincin pada tahun 1978 di Batang-Jawa Tengah, perikanan pukat cincin telah berkembang sangat pesat terutama di utara Jawa Tengah baik dalam jumlah maupun cara penangkapan. Pukat cincin merupakan penghasil terbesar selama periode tahun 1975-1979, di Laut Jawa mencapai 49.000 ton atau 33,8% dari produksi total ikan (Dwiponggo, 1983). Daerah penangkapan pada umumnya ditentukan oleh musim. Pada musim timur (bulan Juni-Nopember) nelayan pukat cincin beroperasi dengan arah haluan 0-45°, sedangkan pada musim barat (bulanDesember- Mei) dengan arah haluan 340-20°, lama perjalanan 4- 13 jam(Hadisubroto, 1975). Dengan demikian, daerah operasi tidak jauh dari pelabuhan perikanan (fishing base).
KONSTRUKSI DAN UJI-COBA PENGOPERASIAN JUVENILE AND TRASH EXCLUDER DEVICE PADA JARING ARAD DI PEKALONGAN
Authors: Salim Agus 
Published: November 2016

Menurut Losse & Ponggo (1977) luas daerah penangkapan Laut Jawa Tengah 16.300 km2 sedangkan di lepas pantai 46.600 km2. Selanjutnyadikatakan bahwa perairan ini cukup kaya akan sumber daya ikan demersal. Berbagai alat tangkap ikan dioperasikan di Laut Jawa. Salah satu alat tangkapyang mempunyai arti penting usaha penangkapan ikan adalah jaring arad. Jaring arad tergolong alat tangkap yang aktif, pengoperasian jaring adalah dengan cara ditarik denganmenggunakan tenaga mesin menyapu dasar perairan. Pada umumnya jaring arad yang dioperasikan oleh nelayan di perairan utara Jawa mempunyai ukuran mata di bagian kantong relatif kecilyaitu 0,75-1 inci. Penggunaan jaring dengan ukuran mata jaring yang relatif kecil tersebut ditengarai telah mengancam kelestarian sumber daya perikanan terutama perikanan pantai karena banyak ikan-ikan muda dan rucah yang ikut tertangkap. Ikan muda disebut juvenile fish dan ikan rucah disebut trash fish.
IS IT POSSIBLE TO SAVE WATER WITHOUT LOSING QUALITY IN THE GUANANDI SEEDLING PRODUCTION?
Authors: Silva Richardson Barbosa Gomes da , Silva Magali Ribeiro da 
Published: November 2016

IS IT POSSIBLE TO SAVE WATER WITHOUT LOSING QUALITY IN THE GUANANDI SEEDLING PRODUCTION? RICHARDSON BARBOSA GOMES DA SILVA1 AND MAGALI RIBEIRO DA SILVA2 1PhD Student in Forest Science, School of Agronomy, UNESP - Univ Estadual Paulista -. Botucatu, SP, Brazil. E-mail: richardsonunesp@gmail.com2Assistant Professor, School of Agronomy, UNESP - Univ Estadual Paulista, Campus Botucatu, SP, Brazil. E-mail: magaliribeiro@fca.unesp.br 1 ABSTRACT In this study we examined if the irrigation depths (8, 11 and 14 mm), applied daily, splitted in two frequencies (two and four times a day) affect the seedling quality of Calophyllum brasiliense Cambess. (Guanandi) at nursery and initial development after planting in pot. The 11 mm irrigation depth produces the same amount of seedlings with suitable root systems for planting as the 14 mm irrigation depth and save 21% of water. The 11 mm irrigation depth, splitted in two times a day, compared to 14 mm irrigation depth, produces higher or equal morphological development, which continues after planting. Keywords: Calophyllum brasiliense, irrigation depth, irrigation frequency, forest nurseries SILVA, R. B. G.; SILVA, M. R. É POSSÍVEL ECONOMIZAR ÁGUA SEM PERDER A QUALIDADE NA PRODUÇÃO DE MUDAS DE GUANANDI? 2 RESUMO Neste estudo examinamos se as lâminas de irrigação (8, 11 e 14 mm), aplicadas diariamente, divididas em duas frequências (duas e quatro vezes ao dia) afetam a qualidade de mudas de Calophyllum brasiliense Cambess. (Guanandi) no viveiro e o desenvolvimento inicial após o plantio em vaso. A lâmina de irrigação 11 mm produz a mesma quantidade de mudas com sistemas radiculares aptos ao plantio que a lâmina de 14 mm e economiza 21% de água. A lâmina de irrigação 11 mm, dividida em duas vezes ao dia, comparada à lâmina de 14 mm, produz maior ou igual desenvolvimento morfológico, que se mantém após o plantio. Palavras-chave: Calophyllum brasiliense, lâmina de irrigação, frequência de irrigação, viveiros florestais
Microdermabrasion for treatment of acne scars in South Indian patients: a clinical study
Authors: Y. G. Anupama , Wahab Afthab Jameela 
Published: November 2016

<p class="abstract"><strong>Background:</strong> Acne is a common disorder with a more prevalence among adolescents and seldom has it caused atrophic scars. Several treatment options are available for atrophic acne scars treatment.<strong> </strong>The objective of the study was to assess the efficiency and safety of microdermabrasion for acne scars in South Indian patients<span lang="EN-IN">.</span></p><p class="abstract"><strong>Methods:</strong> Forty patients (24 males and 16 females) with acne scars were enrolled in the study. Microdermabrasion was done to all patients and repeated at every two weeks intervals for a total of four sittings. Patients were followed up on tenth week. The response to the treatment was assessed by objective and subjective methods.<strong></strong></p><p class="abstract"><strong>Results:</strong> All patients completed the study and follow up period. There were 8 patients with mild, 28 patients with moderate and 4 patients with severe grade of acne scars. At the end of the study, 9 patients (22%) with mild to moderate acne scars showed good response. 30% of patients were satisfied with the treatment with varying degrees. Side effects were transient and mild<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> Microdermabrasion is a safe, easy to perform, well tolerated procedure for treatment of mild to moderate acne scars<span lang="EN-IN">.</span></p>
Ancient Egyptian Blue (CaCuSi4O10) Pigment by Modern Solution Combustion Synthesis Method
Authors: Panagopoulou A. , Karanasios K. , Xanthopoulou G. 
Published: November 2016

<p class="Default"> </p><p class="Default"> The Egyptian blue pigment, CaCuSi<sub>4</sub>O<sub>10</sub>, has been used in ancient Egypt from 3000 BC. This pigment consists of CaCuSi<sub>4</sub>O<sub>10</sub> with variable amounts of wollastonite</p><p>(CaSiO<sub>3</sub>), high amount of Cu oxides, cuprite (Cu<sub>2</sub>O) or tenorite (CuO). It was prepared by melting the high percentage of copper in association with lime and desert sand in the Ancient time. In this work Egyptian blue was produced by solution combustion synthesis (SCS) in homogeneous aqueous solution of composition: cupper and calcium nitrates, sodium silicate and urea. This method permits chemically stable Egyptian blue fast and economic production. The Egyptian blue composition and structure obtained after SCS and calcination were studied by XRD, FTIR and SEM/EDX analysis. Crystallite size and crystal lattice parameters were calculated. An increase in combustion temperature during SHS and calcinations temperature influence Egyptian blue yield and crystallite size, slightly influence parameters of crystal lattice.</p>
Адміністративна відповідальність юридичних осіб: історія і сучасність
Authors: Borodin Ivan , Myronets Oksana 
Published: November 2016

Мета: Юридичні особи здатні акумулювати значно більші фінансові, матеріальні, інтелектуальні ресурси для досягнення своєї мети, ніж окрема фізична особа. Важливою є розробка теоретичних основ, необхідних для розуміння адміністративної відповідальності юридичних осіб і внесення пропозицій щодо удосконалення чинного законодавства про адміністративну відповідальність юридичних осіб, механізму її застосування, систематизації законодавства в цій сфері. Методи: Було використано загальнонаукові, філософські та спеціально-правові методи наукового дослідження. За допомогою загальнонаукових та філософських методів досліджено теоретико-правові засади інституту адміністративної відповідальності юридичних осіб, передумови законодавчого регулювання адміністративної відповідальності юридичних осіб. Метод системного аналізу використано для аналізу сучасного адміністративного законодавства, наукових праць щодо визначення поняття «адміністративна відповідальність юридичних осіб». Догматичний метод був цінним при формулювання висновків і рекомендацій практичного характеру в межах проблематики дослідження. Результати: Вказано, що законодавство про адміністративну відповідальність юридичних осіб перебуває в процесі становлення, запропоновано два можливі шляхи його систематизації. Зауважено, що обидва вони пов’язані з необхідністю усунення неузгодженості у врегулюванні адміністративної відповідальності юридичних осіб з конституційними нормами. Зроблено висновок, що законодавчо слід визнати юридичну особу суб’єктом адміністративної відповідальності. Обговорення: Адміністративна відповідальність юридичних осіб покликана протистояти правопорушенням, захищати законні права та інтереси громадян, держави, юридичних осіб, встановлений порядок управління, а також забезпечувати відновлення порушених прав та відшкодування втрат, що виникли в результаті правопорушень, тягти для правопорушника обтяжливі наслідки організаційного та матеріального характеру. Розробка концепції «адміністративної відповідальності юридичних осіб» і її реалізація є важливою темою для майбутніх досліджень.
Increased Levels of Dissolved Titanium Are Associated With Peri‐Implantitis – A Cross‐Sectional Study
Authors: Safioti Luciana M. , Kotsakis Georgios A. , Pozhitkov Alex E. , Chung Whasun O. , Daubert Diane M. 
Published: November 2016

Background: Peri‐implantitis represents a disruption of the biocompatible interface between the titanium dioxide layer of the implant surface and the peri‐implant tissues. Increasing preclinical data suggest that peri‐implantitis microbiota not only triggers an inflammatory immune response but also causes electrochemical alterations of the titanium surfaces, i.e., corrosion, that aggravate this inflammatory response. Thus, it was hypothesized that there is an association between dissolution of titanium from dental implants, which suggests corrosion, and peri‐implantitis in humans. The objective of this study is to compare levels of dissolved titanium in submucosal plaque collected from healthy implants and implants with peri‐implantitis.Methods: Submucosal plaque from 20 implants with peri‐implantitis and 20 healthy implants was collected with sterile curets from 30 participants. Levels of titanium were quantified using inductively coupled plasma mass spectrometry and normalized for mass of bacterial DNA per sample to exclude confounding by varying amounts of plaque per site. Statistical analysis was performed using generalized estimated equations to adjust for clustering of implants per participant.Results: Implants with peri‐implantitis harbored significantly higher mean levels of titanium (0.85 ± 2.47) versus healthy implants (0.07 ± 0.19) after adjusting for amount of plaque collected per site (P = 0.033).Conclusions: Greater levels of dissolved titanium were detected in submucosal plaque around implants with peri‐implantitis compared with healthy implants, indicating an association between titanium dissolution and peri‐implantitis. Factors triggering titanium dissolution, as well as the role of titanium corrosion in the peri‐implant inflammatory process, warrant further investigation.
VANINTELEKTUALNI ČINIOCI OSTVARENJA DAROVITOSTI
Authors: Letić Milena M. , Lungulov Biljana 
Published: November 2016

Polazeći od savremenih koncepcija darovitosti koje naglašavaju značaj personalnih i sredinskih karakteristika za aktuelizaciju visokih sposobnosti, autorke rada, koristeći metodu teorijske analize, daju pregled istraživanja povezanosti svojstava ličnosti i sredinskih prilika sa ostvarenjem darovitosti. Učinjen je pokušaj da se upotpune saznanja o vanintelektualnoj sferi darovitih u nadi da će se tako dobiti obuhvatnija slika činilaca ostvarenja darovitosti od one kojom se danas raspolaže.
Opšti nalaz svih pomenutih istraživanja sadržan je u konstataciji da sudbina izuzetnih potencijala umnogome zavisi od vanintelektualnih činilaca. Natprosečne sposobnosti su svakako važan elemenat darovitosti, jer omogućuju kvalitetnije bavljenje određenim aktivnostima, ali, same po sebi, one nisu dovoljne da bi se darovitost iskazala u izuzetnim postignućima.
Premda osobe darovite u različitim domenima imaju mnoge zajedničke karakteristike, njihovi profili ličnosti, kao i sredinske prilike, pokazuju i određene specifičnosti, što upućuje na konstataciju da se fenomen darovitosti može precizno sagledati jedino ako se locira u okvire pojedinačnih domena. Stoga, autorke zaključuju da osim multidimenzionalnosti, kao krucijalnog modernog obeležja konstrukta darovitosti, referentni okvir istraživanja ovog problema mora biti definisan i u terminima konkretnog domena manifestovanja izvrsnosti.
The role of language in portfolio learning
Authors: Conrad Dianne 
Published: November 2016

<p>Within the practice of recognizing prior learning (RPL), language issues –writing, the act of capturing language – are critically important facets of portfolio development. Using data drawn from a study of several postsecondary institutions in three countries, this paper examines the role and impact of language in portfolio development processes. Specifically, it considers the dynamics that contribute to learners’ <em>finding </em>appropriate language and their response to that journey, noting that learners pass through several stages of language growth, beginning with learning the language of academic life and recognizing the importance of that “new” language. The paper also discusses the impact of assessors’ use of language and considers the notion of learners’ transformation as they pass through the portfolio learning process.</p><p> </p>
"Chaos rules" revisited
Authors: Murphy David 
Published: November 2016

<p>About 20 years ago, lost in the midst of my PhD research, I mused over proposed titles. I was pretty pleased with myself to come up with ‘Chaos Rules’ (the implied double meaning was deliberate) or, more completely, <em>Chaos Rules: An Exploration of The Work of Instructional Designers in Distance Education</em>. I used the then emerging theories of chaos and complexity to underpin my analysis. So it was with not just a little excitement that I read the call for contributions to this Special Issue. What follows is a ‘walk through’ my thesis, with an emphasis on the contribution of chaos and complexity theory.</p><p> </p>
Emergent, self-directed, and self-organized learning: Literacy, numeracy, and the iPod Touch
Authors: Ricci Carlo Antonio 
Published: November 2016

<p>This paper uses narrative and storying to retell how two girls ages 5 and 7 continue to make use of an iPod touch to expand their literacy and numeracy. The paper explores the stopwatch and alarm features within the clock application, as well as the weather application, and the Internet browsing capability of the iPod touch. It also explores some of the challenges and inequities inherent in using this type of technology. The paper concludes with the author’s belief that it is important to allow learners freedom to explore and freely play with the technology and that emergent, self-directed, and self-organized learning is a natural and gentle approach to lifelong learning.</p><p>Becoming literate and numerate is infinitely complicated, yet very simple. It is infinitely complicated because there are so many variables within and without the individual who is learning these skills that understanding the process fully is nearly impossible. Yet, it is simple because so many successfully become literate and numerate so naturally. Relating to this point Schuerwegen<em> </em>(2011) writes,</p><p>Ergo, when a child grows up in a reading, writing, counting environment, especially an electronically driven society such as ours, he will one day find the need to pick up all these skills, at least as much as he needs them. (p. 22)</p><p> </p>
The Efficacy of Leader’s Islamic spiritual Intelligence Toward Employee Emotional Well-being
Authors: Hastuti Rina 
Published: November 2016

<p><em>The objective of this study is to find the evidence for the efficacy of Religiosity on spirituality workplace. The research conducted by measuring the effect of employee’s perspectives of leader’s islamic spiritual intelligence on employee emotional well-being which mediated by the quality of employee spiritual value. The data was collected from the employees of moslem small medium enterprises on cullinary industry in Surakarta. The 75 samples was analyzed by multivariate analysis (Path Analysis) using SPSS 18 Software Program.The Islamic spiritual intelligence is explained by the variables that reflect the Muhammad SAW characters: sidiq (truthfulness), amanah (trustful), tabliq, and fatanah (wisdom). From the empirical research reveal that the employee spiritual value significantly mediating the effect of sidiq and fatanah toward employee’s emotional wellbeing. Meanwhile the variable of amanah and tabliq has no significant effect to employee spiritual value and employee emotional wellbeing. Therefore the higher the islamic spiritual value of leader (sidiq and fatanah) the higher the spiritual value of employee and the better the quality of employee’s emotional wellbeing</em>. </p>