bluuebunny/crossref_metadata_2025_split huggingface dataset:
Birthweight percentiles for twin birth neonates by gestational age in China
Authors: Zhang Bin , Cao Zhongqiang , Zhang Yiming , Yao Cong , Xiong Chao , Zhang Yaqi , Wang Youjie , Zhou Aifen 
Published: August 2016

AbstractLocalized birthweight references for gestational ages serve as an essential tool in accurate evaluation of atypical birth outcomes. Such references for twin births are currently not available in China. The aim of this study was to construct up-to-data sex specific birth weight references by gestational ages for twin births in China. We conducted a population-based analysis on the data of 22,507 eligible living twin infants with births dated between 8/01/2006 and 8/31/2015 from all 95 hospitals within the Wuhan area. Gestational ages in complete weeks were determined using a combination of last-menstrual-period based (LMP) estimation and ultrasound examination. Smoothed percentile curves were created by the Lambda Mu Sigma (LMS) method. Reference of the 3rd, 10th, 25th, 50th, 75th, 90th, 97th percentiles birth weight by sex and gestational age were made using 11,861 male and 10,646 female twin newborns with gestational age 26–42 weeks. Separate birthweight percentiles curves for male and female twins were constructed. In summary, our study firstly presents percentile curves of birthweight by gestational age for Chinese twin neonates. Further research is required for the validation and implementation of twin birthweight curves into clinical practice.
Nitrogen can improve the rapid response of photosynthesis to changing irradiance in rice (Oryza sativa L.) plants
Authors: Sun Jiali , Ye Miao , Peng Shaobing , Li Yong 
Published: August 2016

AbstractTo identify the effect of nitrogen (N) nutrition on the dynamic photosynthesis of rice plants, a pot experiment was conducted under two N conditions. The leaf N and chlorophyll levels, as well as steady–state photosynthesis, were significantly increased under high N. After the transition from saturating to low light levels, decreases in the induction state (IS%) of leaf photosynthesis (A) and stomatal conductance (gs) were more severe under low than under high N supply. After the transition from low to flecked irradiance, the times to 90% of maximumA(T90%A) were significantly longer under low than under high N supply. Under flecked irradiance, the maximumAunder saturating light (Amax–fleck) and the steady–stateAunder low light (Amin–fleck) were both lower than those under uniform irradiance (AsatandAinitial). Under high N supply,Amax–fleckwas 14.12% lower thanAsat, while it was 22.80% lower under low N supply. The higherIS%, shorter T90%A, and the lower depression ofAmax–fleckfromAsatunder high N supply led to a less carbon loss compared with under a low N supply. Therefore, we concluded that N can improve the rapid response of photosynthesis to changing irradiance.
Controlled creation and displacement of charged domain walls in ferroelectric thin films
Authors: Feigl L. , Sluka T. , McGilly L. J. , Crassous A. , Sandu C. S. , Setter N. 
Published: August 2016

AbstractCharged domain walls in ferroelectric materials are of high interest due to their potential use in nanoelectronic devices. While previous approaches have utilized complex scanning probe techniques or frustrative poling here we show the creation of charged domain walls in ferroelectric thin films during simple polarization switching using either a conductive probe tip or patterned top electrodes. We demonstrate that ferroelectric switching is accompanied - without exception - by the appearance of charged domain walls and that these walls can be displaced and erased reliably. We ascertain from a combination of scanning probe microscopy, transmission electron microscopy and phase field simulations that creation of charged domain walls is a by-product of and as such is always coupled to, ferroelectric switching. This is due to the (110) orientation of the tetragonal (Pb,Sr)TiO3 thin films and the crucial role played by the limited conduction of the LSMO bottom electrode layer used in this study. This work highlights that charged domain walls, far from being exotic, unstable structures, as might have been assumed previously, can be robust, stable easily-controlled features in ferroelectric thin films.
Scalable hybrid chemical manufacture to photothermal therapy: PEG-capped phototransducers
Authors: Byeon Jeong Hoon 
Published: August 2016

AbstractAg-TiO2@polyethylene glycol (PEG) nanoparticles were continuously obtained in a single-pass configuration by appropriately reacting freshly flame-synthesized TiO2 with Ag formed in an ultrasonic aqueous medium containing PEG. When the proposed synthesis was kept constant, the production rate for Ag-TiO2@PEG nanoparticles reached approximately 3 g/h while only using a combination of a lab-scale inverse-diffusion flame (16 mm head diameter) and an ultrasonic Ag(I) cell (50 mL). The synthesized nanoparticles were employed as inducers for in vitro photoinduced therapy to kill cancer cells at different light wavelengths. Measurements of the nanoparticle cytotoxicity revealed that PEG incorporation with the Ag-TiO2 particles significantly decreased the cytotoxicity (cell viability of more than ~91% at 200 μg mL−1 particle concentration) of Ag, and this was comparable with that of TiO2 particles (cell viability of more than ~90%). When 632 nm and 808 nm light was applied to the nanoparticles in the HeLa cells, the viability of the cells was significantly affected [decreased to ~4% (632 nm) and ~26% (808 nm) at 200 μg mL−1, 5 min irradiation time] by surface plasmon resonance heating and photothermal therapy.
Size dependence of structural parameters in fcc and hcp Ru nanoparticles, revealed by Rietveld refinement analysis of high-energy X-ray diffraction data
Authors: Song Chulho , Sakata Osami , Kumara Loku Singgappulige Rosantha , Kohara Shinji , Yang Anli , Kusada Kohei , Kobayashi Hirokazu , Kitagawa Hiroshi 
Published: August 2016

AbstractTo reveal the origin of the CO oxidation activity of Ruthenium nanoparticles (Ru NPs), we structurally characterized Ru NPs through Rietveld refinement analysis of high-energy X-ray diffraction data. For hexagonal close-packed (hcp) Ru NPs, the CO oxidation activity decreased with decreasing domain surface area. However, for face-centered cubic (fcc) Ru NPs, the CO oxidation activity became stronger with decreasing domain surface area. In comparing fcc Ru NPs with hcp Ru NPs, we found that the hcp Ru NPs of approximately 2 nm, which had a smaller domain surface area and smaller atomic displacement, showed a higher catalytic activity than that of fcc Ru NPs of the same size. In contrast, fcc Ru NPs larger than 3.5 nm, which had a larger domain surface area, lattice distortion and larger atomic displacement, exhibited higher catalytic activity than that of hcp Ru NPs of the same size. In addition, the fcc Ru NPs had larger atomic displacements than hcp Ru NPs for diameters ranging from 2.2 to 5.4 nm. Enhancement of the CO oxidation activity in fcc Ru NPs may be caused by an increase in imperfections due to lattice distortions of close-packed planes and static atomic displacements.
Contribution of prostanoid signaling to the evolution of spreading depolarization and the associated cerebral blood flow response
Authors: Varga Dániel Péter , Puskás Tamás , Menyhárt Ákos , Hertelendy Péter , Zölei-Szénási Dániel , Tóth Réka , Ivánkovits-Kiss Orsolya , Bari Ferenc , Farkas Eszter 
Published: August 2016

AbstractThe significance of prostanoid signaling in neurovascular coupling during somatosensory stimulation is increasingly more appreciated, yet its involvement in mediating the cerebral blood flow (CBF) response to spreading depolarization (SD) has remained inconclusive. Selective cyclooxygenase (COX) enzyme inhibitors (NS-398, SC-560) or an antagonist (L161,982) of the EP4 type prostaglandin E2 receptor were applied topically to a cranial window over the parietal cortex of isoflurane-anesthetized Sprague-Dawley rats (n = 60). Global forebrain ischemia was induced by occlusion of both common carotid arteries in half of the animals. SDs were triggered by the topical application of 1M KCl. SD occurrence was confirmed by the acquisition of DC potential and CBF variations were recorded by laser-Doppler flowmetry. EP4 receptor antagonism significantly decreased peak hyperemia and augmented post-SD oligemia in the intact but not in the ischemic cortex. COX-1 inhibition and EP4 receptor blockade markedly delayed repolarization after SD in the ischemic but not in the intact brain. COX-2 inhibition achieved no significant effect on any of the end points taken. The data suggest, that activation of EP4 receptors initiates vasodilation in response to SD in the intact brain and – together with COX-1 derived prostanoids – shortens SD duration in the acute phase of ischemia.
Systematic Review and Meta-Analysis of Preoperative Antisepsis with Combination Chlorhexidine and Povidone-Iodine
Authors: Davies Benjamin , Patel Hiren 
Published: August 2016

Importance Effective preoperative antisepsis is recognized to prevent surgical site infection (SSI), although the definitive method is unclear. Many have compared chlorhexidine (CHG) with povidone-iodine (PVI), but there is emerging evidence for combination usage.
Objective To conduct a systematic review and meta-analysis to evaluate if combination skin preparation (1) reduces colonization at the operative site and (2) prevents SSI compared with single-agent use.
Data Sources A literature search of MEDLINE, Embase, and Cochrane Database of Clinical Trials was performed.
Study Selection Comparative, human trials considering the combination use of CHG and PVI, as preoperative antisepsis, to single-agent CHG or PVI use were included. Studies were excluded from meta-analysis if the use or absence of alcohol was inconsistent between study arms.
Data Extraction and Synthesis The study was performed using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.
Main Outcomes and Measures The primary outcome for meta-analysis was surgical site infection. The secondary outcome was colonization at the operative site.
Results Eighteen publications with a combination of CHG and PVI use were identified. Of these, 12/14 inferred promise for combination usage, including four trials eligible for meta-analysis. Only one trial reported SSI as its outcome. The remaining three considered bacterial colonization. Combination preparation had a pooled odds ratio for complete decolonization of 5.62 (95% confidence interval 3.2 to 9.7, p < 0.00001). There was no evidence of heterogeneity (Cochran's Q 2.1, 2 df, p = 0.35).
Conclusions and Relevance There is emerging, albeit low-quality, evidence in favor of combination CHG and PVI preoperative antisepsis. Further rigorous investigation is indicated.
Functional Reconstruction of Temporomandibular Joint after Resection of Pigmented Villonodular Synovitis with Extension to Infratemporal Fossa and Skull Base: A Case Report
Authors: Vellutini Eduardo , Alonso Nivaldo , Arap Sérgio , Godoy Luís , Souza e Souza Ricardo , Mattedi Rômulo , de Oliveira Matheus 
Published: August 2016

Introduction Pigmented villonodular synovitis (PVNS) is a benign but aggressive lesion arising from sinovia. The temporomandibular joint (TMJ) is hardly ever involved.
Methods We describe a case of PVNS arising in the left TMJ involving infratemporal fossa soft tissue and the skull base; we also present the reconstruction.
Results A 37-year-old woman had progressive mandibular swelling for 6 months. Computed tomography of the skull revealed an osteolytic lesion in the left TMJ, involving the upper mandible, condyle, and glenoid fossa and extending to the infratemporal fossa and fossa media through a defect in temporal bone. Surgical management included a left pterional craniotomy to reach the temporal skull base and resect the intracranial tumor and a facial approach with partial left mandibulectomy and resection of left condyle, glenoid fossa, and tumor removal in infratemporal fossa. Mandible function was restored with prosthetic reconstruction of the condyle. She progressively started to eat solid foods after 3 months, becoming increasingly functional and asymptomatic. At 30 months' follow-up, she had no sign of tumoral recurrence and showed asymptomatic and normal TMJ function.
Conclusion PVNS should be considered in the differential diagnosis of bone neoplasms affecting young patients. In such cases, radical excision is mandatory and TMJ prosthesis for local reconstruction may be used to preserve functionality.
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
Authors: Yang Wan Seok , Kim Katherine J. , Gaschler Michael M. , Patel Milesh , Shchepinov Mikhail S. , Stockwell Brent R. 
Published: August 2016

Significance
Ferroptosis is a regulated form of cell death induced by loss of glutathione peroxidase 4 (GPX4) phospholipid peroxidase activity and lethal accumulation of reactive oxygen species. Small-molecule inhibitors of GPX4 induce ferroptosis; however, the interaction between these inhibitors and GPX4 has remained elusive, as has the identity of the reactive oxygen species that drive execution of ferroptosis. We identified here a ligand-binding site on GPX4 and determined the specific lipids oxidized during ferroptosis. We further identified two key drivers of lipid peroxidation during ferroptosis: lipoxygenases and phosphorylase kinase G2. These findings reveal a previously enigmatic mechanism of ferroptotic lipid peroxide generation and suggest new strategies for pharmacological control of ferroptosis and diseases associated with this mode of cell death.
Histone arginine methylation in cocaine action in the nucleus accumbens
Authors: Damez-Werno Diane M. , Sun HaoSheng , Scobie Kimberly N. , Shao Ningyi , Rabkin Jaclyn , Dias Caroline , Calipari Erin S. , Maze Ian , Pena Catherine J. , Walker Deena M. , Cahill Michael E. , Chandra Ramesh , Gancarz Amy , Mouzon Ezekiell , Landry Joseph A. , Cates Hannah , Lobo Mary-Kay , Dietz David , Allis C. David , Guccione Ernesto , Turecki Gustavo , Defilippi Paola , Neve Rachael L. , Hurd Yasmin L. , Shen Li , Nestler Eric J. 
Published: August 2016

Significance
We demonstrate that protein-R (arginine)-methyltransferase-6 (PRMT6) and its associated histone mark, asymmetric dimethylation of R2 on histone H3 (H3R2me2a), are decreased in the nucleus accumbens (NAc) of mice and rats after repeated cocaine exposure, as well as in the NAc of cocaine-addicted humans. We show that cocaine-induced PRMT6 down-regulation occurs selectively in NAc medium spiny neurons expressing dopamine D2 receptors (D2-MSNs) and serves to protect against cocaine-induced behavioral abnormalities. Furthermore, we provide the first, to our knowledge, genome-wide characterization of H3R2me2a within a specific brain region in vivo, and identify Src kinase signaling inhibitor 1 (Srcin1 or p140Cap) as a key target for this chromatin modification. Srcin1 induction in the NAc after cocaine exposure, which is associated with reduced Src signaling, decreases cocaine reward.
Assembly scaffold NifEN: A structural and functional homolog of the nitrogenase catalytic component
Authors: Fay Aaron W. , Blank Michael A. , Rebelein Johannes G. , Lee Chi Chung , Ribbe Markus W. , Hedman Britt , Hodgson Keith O. , Hu Yilin 
Published: August 2016

Significance
This work provides direct evidence for the formation of an M-cluster on the assembly scaffold NifEN, establishing NifEN as the second known protein that houses a nitrogenase cofactor. A “half-on, half-off” scheme of cofactor biosynthesis can be proposed based on the outcome of this study, which suggests an asymmetric nature of the assembly sites in the seemingly equivalent αβ-halves of NifEN and a coordination of various biosynthetic events via a unique conformational switch on/off mechanism. The comparable substrate-reducing capabilities of NifEN and NifDK establish the former as a structural and functional homolog of the latter, providing a proof-of-concept for the feasibility of probing key catalytic features of NifDK via reconstruction of a NifDK equivalent on the basis of a “simplified” template, NifEN.
Sport science integration: An evolutionary synthesis
Authors: Balagué N. , Torrents C. , Hristovski R. , Kelso J. A. S. 
Published: August 2016

AbstractThe aim of the paper is to point out one way of integrating the supposedly incommensurate disciplines investigated in sports science. General, common principles can be found among apparently unrelated disciplines when the focus is put on the dynamics of sports‐related phenomena. Dynamical systems approaches that have recently changed research in biological and social sciences among others, offer key concepts to create a common pluricontextual language in sport science. This common language, far from being homogenising, offers key synthesis between diverse fields, respecting and enabling the theoretical and experimental pluralism. It forms a softly integrated sports science characterised by a basic dynamic explanatory backbone as well as context‐dependent theoretical flexibility. After defining the dynamic integration in living systems, unable to be captured by structural static approaches, we show the commonalities between the diversity of processes existing on different levels and time scales in biological and social entities. We justify our interpretation by drawing on some recent scientific contributions that use the same general principles and concepts, and diverse methods and techniques of data analysis, to study different types of phenomena in diverse disciplines. We show how the introduction of the dynamic framework in sport science has started to blur the boundaries between physiology, biomechanics, psychology, phenomenology and sociology. The advantages and difficulties of sport science integration and its consequences in research are also discussed.
Automated identification of antibiotic overdoses and adverse drug events via analysis of prescribing alerts and medication administration records
Authors: Kirkendall Eric S , Kouril Michal , Dexheimer Judith W , Courter Joshua D , Hagedorn Philip , Szczesniak Rhonda , Li Dan , Damania Rahul , Minich Thomas , Spooner S Andrew 
Published: August 2016

Objectives: Electronic trigger detection tools hold promise to reduce Adverse drug event (ADEs) through efficiencies of scale and real-time reporting. We hypothesized that such a tool could automatically detect medication dosing errors as well as manage and evaluate dosing rule modifications.Materials and Methods: We created an order and alert analysis system that identified antibiotic medication orders and evaluated user response to dosing alerts. Orders associated with overridden alerts were examined for evidence of administration and the delivered dose was compared to pharmacy-derived dosing rules to confirm true overdoses. True overdose cases were reviewed for association with known ADEs.Results: Of 55 546 orders reviewed, 539 were true overdose orders, which lead to 1965 known overdose administrations. Documentation of loose stools and diarrhea was significantly increased following drug administration in the overdose group. Dosing rule thresholds were altered to reflect clinically accurate dosing. These rule changes decreased overall alert burden and improved the salience of alerts.Discussion: Electronic algorithm-based detection systems can identify antibiotic overdoses that are clinically relevant and are associated with known ADEs. The system also serves as a platform for evaluating the effects of modifying electronic dosing rules. These modifications lead to decreased alert burden and improvements in response to decision support alerts.Conclusion: The success of this test case suggests that gains are possible in reducing medication errors and improving patient safety with automated algorithm-based detection systems. Follow-up studies will determine if the positive effects of the system persist and if these changes lead to improved safety outcomes.
Trabeculectomy and Combined Phacoemulsification-Trabeculectomy: Outcomes and Risk Factors for Failure in Primary Angle Closure Glaucoma
Authors: Song Brian J. , Ramanathan Meera , Morales Esteban , Law Simon K. , Giaconi JoAnn A. , Coleman Anne L. , Caprioli Joseph 
Published: August 2016

Purpose:
To evaluate tonometric outcomes of patients with primary angle closure glaucoma (PACG) who have undergone trabeculectomy with mitomycin C (MMC) with and without concurrent phacoemulsification and to identify risk factors for postoperative failure.

Patients and Methods:
Retrospective cohort study of 44 eyes of 33 phakic patients who underwent trabeculectomy with MMC with or without combined phacoemulsification for PACG. The primary endpoint was qualified tonometric success at 12 months according to predefined criteria. LogMAR visual acuity, number of glaucoma medications, and postoperative complications were also evaluated. Cox proportional hazard regression analysis was performed to identify potential risk factors for trabeculectomy failure.

Results:
Mean intraocular pressure (IOP) decreased from 21.3±7.9 to 12.2±3.9 mm Hg at 12 months (P<0.001) in all patients. A significant reduction in mean number of glaucoma medications (P<0.001) was also seen. There was no change in logMAR visual acuity (P=0.39) after 12 months. There were no significant intergroup differences in mean IOP (P=0.42), number of glaucoma medications (P=0.85), or logMAR visual acuity (P=0.42) between the trabeculectomy versus combined surgery groups after 12 months. Increased age, greater baseline IOP, limbus-based conjunctival flaps, and MMC duration >1 minute were associated with decreased risk of surgical failure. Concurrent phacoemulsification at the time of trabeculectomy did not alter tonometric success or rate of complications.

Conclusions:
In phakic patients with PACG, trabeculectomy with MMC significantly reduces IOP and number of glaucoma medications at 12 months without change in visual acuity. However, success rates are modest when based on more demanding tonometric criteria.
Mycobacterium goodii: An Emerging Nosocomial Pathogen
Authors: Salas Natalie Mariam , Klein Nicole 
Published: August 2016

Abstract

Mycobacterium goodii, a rapidly growing nontuberculous mycobacterium, is an emerging pathogen in nosocomial infections. Its inherent resistance patterns make it a challenging organism to treat, and delays in identification can lead to poor outcomes. We present a case of cardiac device pocket infection with M. goodii, complicated by both antibiotic resistance and drug reactions that highlight the challenges faced by clinicians trying to eradicate these infections. We also present a brief review of the English literature surrounding this disease, including a table of all reported cases of M. goodii infections and their outcomes to act as guide for clinicians formulating treatment plans for these infections. A clear understanding of diagnostic methods and treatment caveats is essential to curing infections caused by these organisms.