bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learning Curve for Pilonidal Sinus Surgery: The Best Option for Budding Surgeons
Authors: Gupta Anurakshat , Anand Sunil , Mehrotra Sandeep , Khidtta Kamalkant 
Published: July 2016

AbstractBackgroundSurgery for pilonidal sinus has no gold standard, and results depend purely on surgeon preference of procedure and experience. Till date, there has been no study comparing the surgical outcomes when performed by residents. Therefore, we designed our study to compare the short‐term outcomes of Karydakis’ and Limberg’s flap procedures in the treatment of pilonidal disease when performed by surgical residents.MethodA prospective, double‐blinded, observational study was carried out at Command Hospital, Pune, India. Twenty‐five consecutive patients undergoing each of the Karydakis’ and Limberg’s flap procedures (n = 50) were enrolled in the study. All patients had a primary sinus opening. Patients with a frank pilonidal abscess were excluded, but patients with history of intermittent purulent discharge even during time of surgery were included.ResultsThere was a significantly higher rate of infection in the Karydakis’ group (9/25) as compared to the Limberg’s flap group (3/25) and also a higher rate of complete wound dehiscence (2/25 vs 1/25).ConclusionLimberg’s flap procedure appears to be superior to Karydakis’ procedure, and the results are reproducible even by budding surgeons with little experience in the procedure.
Herpes Zoster Overlying Recently Placed Central Venous Access Site: A Case Report
Authors: Hess Rebecca A. , Gunnerson Kyle , Kahler John 
Published: July 2016

AbstractHerpes zoster, commonly called shingles, is a disease that results from the reactivation of varicella zoster virus. Local trauma has been reported as a precipitant for reactivation, but this condition is rarely seen localized to a fresh surgical incision. We present the case of a patient who developed shingles overlying the incision site of a recently buried central venous access port, illustrating the need to consider this diagnosis as a unique imposter of localized infection or reaction at sites of recent procedural trauma.
Local perceptions of the impact of group interpersonal psychotherapy in rural Uganda
Authors: Lewandowski R. E. , Bolton P. A. , Feighery A. , Bass J. , Hamba C. , Haroz E. , Stavrou V. , Ndogoni L. , Jean-Pierre A. , Verdeli H. 
Published: July 2016

Background.This study investigated local perceptions of changes stemming from a long-standing Group Interpersonal Psychotherapy (IPT-G) program for the treatment of depression in rural Uganda. The study was conducted in a low-income, severely HIV/AIDS-affected area where in 2001 the prevalence of depression was estimated at 21% among adults.Method.Data were collected using free-listing and key informant qualitative interviews. A convenience sample of 60 free-list respondents was selected from among IPT-G participants, their families, and other community members from 10 Ugandan villages. Twenty-two key informants and six IPT-G facilitators were also interviewed.Results.Content analysis yielded five primary categories of change in the community related to the IPT-G program: (1) improved school attendance for children; (2) improved productivity; (3) improved sanitation in communities; (4) greater cohesion among community members; and (5) reduced conflict in families. Community members and IPT-G facilitators suggested that as depression remitted, IPT-G participants became more hopeful, motivated and productive.Conclusion.Results suggest that providing treatment for depression in communities with high depression prevalence rates may lead to positive changes in a range of non-mental health outcomes.
Early Devonian (Pragian) vertebrates from the northern Roberts Mountains, Nevada
Authors: Burrow Carole J. , Murphy Michael A. 
Published: July 2016

AbstractFossil fish are poorly represented in middle Lower Devonian deposits of the western United States. Here we describe vertebrate microremains from mid-Pragian levels in the Kobeh Member, McColley Canyon Formation, central Nevada. The species diversity of the assemblages is low and dominated by the acanthodianNostolepis costataGoujet, 1976. This species is found in older (late Lochkovian–early Pragian) deposits in France and Spain and mid-Pragian or slightly younger deposits in Saudi Arabia. This distribution suggests dispersal to the west from the Armorica terrane around the south of Laurussia to the Nevada region, and southeastward to Arabia, on the northern margin of Gondwana.
Conflicting perspectives on neurobehavioral theories of the depressive disorders and drug actions
Authors: Katz Martin M. 
Published: July 2016

ObjectiveA prominent theory of depression focusses on neural plasticity and stress as central issues in seeking to develop a pattern of identifiable biological markers for the depressive disorders. Relative neglect, however, of clinical factors in that theory limits the uncovering of markers and opens to question their methodological approach. A conflicting theory, the ‘opposed neurobehavioral states’, based on dimensional analysis of monoamine neurotransmitter systems and behavioural factors is presented. This perspectives paper contrasts the two approaches viewing the biomarkers theory as premature at this point in the progress of depression research.MethodStudies developed to support the biomarkers theory and the opposed neurobehavioral states theory are examined for their strengths and limitations in explaining the nature of the disorder and the actions of therapeutic drugs. Reference is made to reviews of the many studies on biomarkers and the recent work that supports the opposed neurobehavioral states theory.DiscussionMain issue: the biomarkers theory sets important goals, but despite the many advances in the neural investigations of factors underlying depression, is still not successful in specifying markers. Thus, it is believed to be applying the wrong methodologic approach and premature in its claims. Perspective: the ‘opposed neurobehavioral’ theory is limited in its breadth of research. It applies, however, the dimensional approach to the clinical side of the problem, a methodological approach more likely to be effective in selecting the best clinical treatment and open to a more productive path to understanding of the nature of the disorder in future research.
Renal Blood Flow in Twins
Authors: Kornacka M. K. , Burzyńska E. , Gadzinowski J. 
Published: July 2016

AbstractThe aim of this preliminary study was the estimation of renal blood flow in 16 premature newborns from twin pregnancies with mean body weight 1270 g and mean gestational age 29 weeks.In control group we have 16 singleton newborns with mean gestational age 29 weeks and mean birth weight 1240 g. In both intervention and control group we have the similar clinical symptoms. The renal blood flow was carried out in the first day of life with the Acuson 128 XP Colour Doppler using the 6 and 7 MHz linear transducer. The renal blood flow parameters-PI, RI, Vmax, Vmin Vmean were measured in right and left renal arteries in theirs courses from the aorta to the renal hilus, by color sinal. In the investigation group the mean value of RI in right and left renal artery was 0,88. Mean PI in right vessel was 1,67 and in left 1,56. Mean V min in right and in left artery was 0,03 and mean V max in right artery was 0,34 and in left 0,33. Mean value of mean velocity in right vessels was 0,18 and in left 0,19.In control group we observed in right artery mean value of PI 1,74 and in left 1,6. Mean RI was 0,86 and 0,86 in right vessel in left vessel. Mean V min was 0,05 in right and 0,04 in left artery. Mean V max was 0,37 in right and 0,34 in left artery. Mean value of V mean was 0,19 in right artery and 0,18 in left artery.Using the student, Mann-Whitney and Shapiro-Wilk tests we have not observed statistically significant difference of Doppler parameters between control and investigation group and between the left and right artery. Although in newborns with broad PDA we noted significant higher value of RI (0,97, 0,98) than in newborns without PDA (0,78, 0,81).
Multiple Pregnancy: Factors Contributing to Early Infant's Breast-feeding – Own Experience
Authors: Czeszyńska M.B. , Kowalik K. 
Published: July 2016

AbstractThe aims of the study were as follows: 1. to evaluate the effectiveness of current program to promote breast-feeding in our population of infants from multiple pregnancy; 2. to define factors responsible for failure in early breast-feeding establishing and /or maintaining breastfeed during the hospitalization of the babies in neonatal department. 122 newborn infants (2 sets of triplets and 58 twin pairs) born in the Clinic for Pathology of Pregnancy and Labor in Szczecin, Poland, in the years 1995 (January) – 1999 (May) from multiple pregnancy were included in the study. In the examined material there were estimated neonatal conditions at birth, neonatal complications, which may disturb successful breast-feeding as well as other factors contributing to early breast-feeding, the way of feeding the babies during neonatal period and the mean time of starting breast-feeding. It was found that most of the examined babies were born with the features of prematurity: mean gestational age was 35,6 ± 2,2 weeks and mean birthweight – 2225,3 ± 193,2 grams. Only 57,4% of babies were born in good conditions according to Apgar scores. Factors which influence in a negative way early breast-feeding were as follows: respiratory disturbance (22,1%), temporary oral nutrition intolerance due to sickness of the baby or early onset of infections (27,5%), operative delivery (62,3%), medicine taken by mothers (13,9%) and failure in maternal lactation (8,2%). Factors disturbing a normal course of breast-feeding were: fototherapy due to hyperbilirubinemia (20,5%) and late onset of infections (1,6%). In most cases breast-feeding was started 3-4 days after birth and the most frequent way of feeding was formula followed or in combination with maternal milk (at discharge in 86,9% of babies).We concluded that exclusive breast-feeding, despite program of promotion, is a rarity in population of newborn babies born from multiple pregnancy; time to start breast-feeding in this population is usually 3-4 days after delivery. Most pre-term and full-term twins are discharged from neonatal department on maternal milk – exclusively or in combination with formula in situation of scarce maternal milk for two or more infants – what should be considered as our professional success.
Quantitative Estimates of ABH Secretion in Saliva of Human Twins
Authors: Sharma K. , Sharma S. 
Published: July 2016

AbstractBlood and saliva samples of 122 like-sexed twin pairs (65 MZ and 57 DZ) living in Chandigarh (India) were analyzed for ABH polymorphism. The results indicated that ABH secretions were independent of ABO blood groups though there was an indication of higher incidence of non-secretors among ‘O’ blood group twin individuals. No significant differences were observed between twins and singletons in secretor gene frequency estimates. The quantitative data revealed that mean titre scores for H substances were lower than that for A and B substances. F test contrasting intra-pair variance between zygosities for ABH quantitative secretions was highly significant indicating stronger genetic component of variation. The results suggested that quantitative assay of ABH secretions would be a better indicator for zygosity determination than mere qualitative differentiation.
Mosaic Partial Trisomy of Chromosome 5 (q33-q ter) Associated with Fetal Polycystic Kidneys
Authors: Kriplani A. , Banerjee N. , Jobanputra V. , Kucheria K. 
Published: July 2016

AbstractA case of de novo mosaic partial trisomy of chromosome 5 (q33-q ter) in a stillborn male fetus with bilateral polycystic kidneys, and atrial septal defect, is reported. Fetal cord blood sampling was carried out at 25 weeks of gestation because of bilateral polycystic kidneys with severe oligohydramnios observed on ultrasound examination of the fetus. The family history was notable for the presence of similar phenotypic abnormality in the mother and sibling. However, no chromosomal abnormality was detected in other family members. Significance of this rare chromosomal abnormality and its association with congenital malformations in the fetus and in the family is being discussed.
Etiology and Management of Monoamniotic Twin Discordant for Anencephaly
Authors: Kriplani A. , Banerjee N. , Takkar D. 
Published: July 2016

AbstractA case of monoamniotic monochorionic (MAMC) female twins, with one twin being anencephalic, and the co-twin being normal, is reported. Twin to twin transfusion syndrome was also noted. The reasons for anencephaly in association with monozygotic (MZ) twinning are discussed. The management of such a case is presented.
Perinatal Morbidity and Mortality Rates in Twin Pregnancies – A 15-Year Review Study from Athens
Authors: Liapis A. E. , Hassiakos D. K. , Panagopoulos P. P. 
Published: July 2016

AbstractThere were 150 deliveries of twin pregnancies over 26 weeks in our hospital. The incidence of twin pregnancies was 1.0% in a population consisting of Greek nationals. Seventy five (50%) were term at delivery whereas 75 (50%) were premature (mean gestational age at delivery 36.5 weeks). The birth weight at delivery ranged from 350 grs to 4,050 grs with mean birth weight for the 1st and 2nd twin of 2,404 grs and 2,384 grs, respectively. One hundred and forty four (48%) neonates had weights between 1,501 to 2,500 grs. Twenty two (9.57%) neonates had weights between 1,501 grs to 2,500 grs. The perinatal mortality when birth weights exceeded 1,500 grs was 7.32%. In total, 186 (62%) newborns were delivered vaginally and 114 (38%) by cesarean section. Forceps were used in 4.33% of the cases and breech extraction was performed in 2.33%. The mode of delivery and perinatal mortality rates were not correlated for both twins (p>0.05). The most common causes of death were hyaline membrane disease (48.5%), immaturity (18.2%), congenital abnormalities (15.1%), septicemia (12.1%) and asphyxia (6.06%). Prematurity seems to constitute the most common cause of perinatal deaths while the mode of delivery found to be irrelevant to perinatal mortality.
Come Nacque l'Istituto Mendel
Authors: Gedda Luigi 
Published: July 2016

Nelle aule delle Università di Pavia, Milano e Torino che ho frequentato a motivo dei continui spostamenti della mia famiglia ho trascorso e concluso il mio “curriculum” conseguendo la laurea in Medicina nel 1927 e poi la Libera Docenza in Patologia Speciale Medica nel 1931.Nel mio trasferimento a Roma ebbi l'intuizione della Genetica studiando i caratteri somatici di una coppia di gemelli identici osservandone la concordanza contemporanea caratteristica ed in particolare la concordanza anche quantitativa di polimorfismi ematici, in particolare delle frazioni del glutatione ematico. Le concordanze nei gemelli monozigotici mi aprirono la strada alla genetica. Questo avvenne nel 1933.Nel 1938, ebbi occasione di conoscere Madre Luisa Tincani che avendo fondato un Istituto Superiore parificato per religiose si trovava in difficoltà perché avrebbe dovuto rispettare il decreto del Governo fascista sull'insegnamento delle leggi razziali. Ritenni che avrei potuto aggirare l'ostacolo insegnando a quelle religiose le leggi di Mendel che sono il punto di partenza per lo studio di ogni carattere ereditario normale o patologico.Quel mio corso andò benissimo in quanto insegnai non solo le leggi di Mendel ma conobbi la figura di un grande personaggio sacerdote, confessore dei prigionieri nel carcere dello Spielberg e Abate che, nel giardino del convento conduceva le sue esperienze che ebbero come oggetto principale il pisum sativum. cioè il pisello.Mentre andavo approfondendo la mia conoscenza dell'Abate agostiniano Gregorio Mendel mi sorprendevo che a Roma non ci fosse nessuna traccia di lui. Di qui nacque l'idea di creare in Roma un Istituto dedicato alla Genetica che portasse il suo nome anche perché questa scienza aveva, nel frattempo, fatto dei passi giganteschi, per cui progettai di costruire nelle adiacenze della Università “La Sapienza” un Istituto che portasse il nome di Mendel (Fig. 1).
Are Differences between Twins a Result of Mutual Rivalry?
Authors: Borg J. G. 
Published: July 2016

AbstractThe sexual index included in the Szondi test makes it possible to define the domains of an individuals “internal sex” or gender – especially the degree of the subject's bisexuality. This index was employed in a comparison between partners reared together in 62 monozygotic and 23 dizygotic pairs of twins. The observed incongruence in 1/3 MZ pairs would not appear to derive totally from errors of measurement. In most of these pairs it is competition which underlies the incongruence seen on the sexual index. It was further observed that the congruence here as in general in female pairs is clearly more marked than in males. A hypothesis was proposed, whereby competition for dominance is a distinctively major-tonality (masculinity) characteristic. The incongruence is more conspicuous among males because males are in general more markedly major-toned than females. This hypothesis was borne out. It is thus necessary here as in general to adopt two sex variables in parallel: external (i.e. matricular) sex and internal sex (gender). It is due to the presence of these competitive pairs that the means and especially deviations of twins' test results will consistently diverge from those in the population at large.
Abstraction Skilfulness in Monozygotic and Dizygotic Twin Pairs
Authors: Nicole S. , Miglio C. Del 
Published: July 2016

AbstractThe computerized version of the Wisconsin Card Sorting Test (WCST) was administered to a sample of 96 subjects (Ss), constituted in equal parts by monozygotic twins (MZ), dizygotic twins (DZ), unique children and couples of “almost contemporary” brothers. The statistic tests (Analysis of principal components, ANOVA) underline, as far as the rapidity to define a category is concerned, a statistically significant difference between DZ and singletons, independently from the fact that the latter may be unique children. A significant difference emerged neither between MZ and singletons, nor between MZ and DZ.
Temperament Development to 30 Months of Age in Discordant Twin Pairs
Authors: Riese M. L. 
Published: July 2016

AbstractTwins within pairs often have different weights at birth. A difference of 15% or greater is defined as discordance for weight and is considered to place one or both infants at risk. Temperament differences had been found in the neonatal period for full-term discordant cotwins, but not for preterm discordant cotwins, suggesting that continued gestation for discordant twins was a risk variable for early behavior. 30 pairs of fullterm and 17 pairs of preterm discordant pairs were followed at 6, 9, 12, 18, 24, and 30 months of age. Group differences were observed for the longitudinal maintenance of cotwin discordance in physical measures, with preterm cotwins becoming more like each other. In laboratory assessments, temperament differences no longer were observed between the larger and smaller cotwins. Questionnaires indicated that mothers generally did not differentiate between their larger and smaller cotwin children in temperament ratings, except for ratings of mood for the fullterm pairs. Thus, emotionality was the only temperament dimension that differentiated between the fullterm discordant twins both in the neonatal period and at later ages. In the main, it was concluded that the fullterm discordant twins overcame the adverse in-utero influences on early behavioral development.
Uniparental Disomy and Genome Imprinting: an Overview
Authors: Engel E. 
Published: July 2016

The following paper is concerned with potential changes in the normal epigenetic process in a diploid individual, when a chromosome pair or segment is inherited from one parent only, instead of the expected biparental contribution. This aberrant mode of transmission arises from the high rate of gamete aneuploidy in humans. It has received the name uniparental disomy (UPD), and has emerged as an important factor in the new field of nontraditional inheritance, depicted in Table 1.The following definitions may foster a better understanding of this discussion.UPDis the inheritance ofbothcopies of a chromosome [or chromosomal segment(s)] from asingleparent, instead of the normal biparental transmission of the pair. Inisodisomy,the two uniparental copies areidentical, being derived from the same parental chromosome. Inheterodisomy, the two uniparental chromosomes aredifferent, being derived from the homologues of a pair.
Medical and Clinical Genetics: Their Roots and Challenge
Authors: Polani P.E. 
Published: July 2016

The origins and development of human, medical and clinical genetics are interwoven and yet each of these disciplines follows its own path.The beginnings of a systematic human genetics can be traced to the middle of the 19th century, but it took human genetics almost 100 years to mature fully and influence medicine. Its origins can be traced to the work of three scientists: Galton, Pearson and Bateson.In 1865, 6 years after Darwin had published Origin of Species in London, and the year when Mendel's paper, “Experiments on Plant Hybrids”, was published in Brunn, Galton, also in London, set out his first ideas on human heredity. His thinking then developed in two directions. The first laid the foundations for the scientific study of human heredity through biometrics and quantitative genetics. This part of Galton's thinking is summarized in his epitaph: “the dominant idea of his life's work was to measure the influence of heredity on the mental and physical attributes of mankind”.Galton's other line dealt with the application of heredity through eugenics, a word that Galton coined to signify “well bred”. He wanted, I quote his words: “to produce a highly gifted race of Man by judicious marriage through several generations”. Families of merit should be identified and positively encouraged to breed; conversely, the “ weak could find a welcome … in celebrate monasteries”.
Maternal Uniparental Disomy for Chromosome 14
Authors: Coviello D.A. , Panucci E. , Mantero M.M. , Perfumo C. , Guelfi M. , Borrone C. , Bricarelli F. Dagna 
Published: July 2016

AbstractA girl carrying a de novo balanced 13-14 robertsonian translocation showed a clinical phenotype with severe hypotonia, hyperextensible joints, frontal bossing, asymmetric face, no mental retardation, severe scoliosis and motor delay. In situ hybridization analysis on chromosome spreads revealed the presence of the two centromeres in the rearranged chromosomes. Molecular analysis on genomic DNA showed the presence in the proposita of two chromosomes 14 of maternal origin and no chromosome 14 from the father indicating a maternal monocentric uniparental disomy for chromosome 14 (mUPD14). Our patient shows several similarities with other reported cases of mUPD14, suggesting imprinting of a region(s) of chromosome 14 and defining a possible mUPD14 Syndrome.