bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature Excursion Management: A Tier-Based Approach for Commercial Oral Solid Dosage Forms
Authors: Unnikandam Veettil Shalini Raj , Respicio Gianna , Zhang DeeDee , Garcia Daniel , Malta Stephanie , Long Hong 
Published: October 2024

AbstractTemperature excursions during product storage, transportation, and handling can deteriorate product quality. Following a temperature excursion event, the impact of the event on the product quality should be evaluated to determine if the product can be used or if it needs to be discarded. Pharmaceutical companies are required to have defined procedures for managing temperature excursions and performing impact assessment after an excursion occurs. In an increasingly complex supply chain, it is vital to develop processes that can expedite the review of these events. A tier-based approach is presented for analyzing the impact of temperature excursion on commercial small molecule drug products intended to be stored at room temperature. Utilization of each of the three tiers is based on whether the excursion temperature and/or excursion duration are within a predetermined, product-specific, allowable range. The stress study temperature defines the allowable temperature range, while the allowable duration is determined using a mathematical approach outlined in this article. Tier 1, specific to the product, allows products to be dispositioned for use without further assessment when temperature excursion events fall within both the product-specific allowable excursion temperature and duration ranges. Tier 2 applies when the excursion temperature is within the allowable range, but the duration exceeds it. Lot-specific release data is used for impact assessment in this tier. Finally, Tier 3 utilizes Arrhenius extrapolation to predict the final degradation and perform the impact assessment when the excursion temperature surpasses the allowable temperature range.
Graphical Abstract
The Scribble–SGEF–Dlg1 complex regulates E-cadherin and ZO-1 stability, turnover and transcription in epithelial cells
Authors: Rabino Agustin , Awadia Sahezeel , Ali Nabaa , Edson Amber , Garcia-Mata Rafael 
Published: October 2024

ABSTRACT
SGEF (also known as ARHGEF26), a RhoG specific GEF, can form a ternary complex with the Scribble polarity complex proteins Scribble and Dlg1, which regulates the formation and maintenance of adherens junctions and barrier function of epithelial cells. Notably, silencing SGEF results in a dramatic downregulation of both E-cadherin and ZO-1 (also known as TJP1) protein levels. However, the molecular mechanisms involved in the regulation of this pathway are not known. Here, we describe a novel signaling pathway governed by the Scribble–SGEF–Dlg1 complex. Our results show that the three members of the ternary complex are required to maintain the stability of the apical junctions, ZO-1 protein levels and tight junction (TJ) permeability. In contrast, only SGEF is necessary to regulate E-cadherin levels. The absence of SGEF destabilizes the E-cadherin–catenin complex at the membrane, triggering a positive feedback loop that exacerbates the phenotype through the repression of E-cadherin transcription in a process that involves the internalization of E-cadherin by endocytosis, β-catenin signaling and the transcriptional repressor Slug (also known as SNAI2).
Breast tumor segmentation using neural cellular automata and shape guided segmentation in mammography images
Authors: Ali Mudassar , Wu Tong , Hu Haoji , Mahmood Tariq 
Published: October 2024

Purpose
Using computer-aided design (CAD) systems, this research endeavors to enhance breast cancer segmentation by addressing data insufficiency and data complexity during model training. As perceived by computer vision models, the inherent symmetry and complexity of mammography images make segmentation difficult. The objective is to optimize the precision and effectiveness of medical imaging.

Methods
The study introduces a hybrid strategy combining shape-guided segmentation (SGS) and M3D-neural cellular automata (M3D-NCA), resulting in improved computational efficiency and performance. The implementation of Shape-guided segmentation (SGS) during the initialization phase, coupled with the elimination of convolutional layers, enables the model to effectively reduce computation time. The research proposes a novel loss function that combines segmentation losses from both components for effective training.

Results
The robust technique provided aims to improve the accuracy and consistency of breast tumor segmentation, leading to significant improvements in medical imaging and breast cancer detection and treatment.

Conclusion
This study enhances breast cancer segmentation in medical imaging using CAD systems. Combining shape-guided segmentation (SGS) and M3D-neural cellular automata (M3D-NCA) is a hybrid approach that improves performance and computational efficiency by dealing with complex data and not having enough training data. The approach also reduces computing time and improves training efficiency. The study aims to improve breast cancer detection and treatment methods in medical imaging technology.
Does parents’ retirement influence the fertility intentions of subsequent generations among internal migrant populations? Evidence from China
Authors: Cai Tianxin , Ma Shilong , Zhong Renyao 
Published: October 2024

Objectives
The fertility health of the migrating population has attracted significant attention. This article examines the impact of parental retirement on the fertility intentions of the offspring among the internal migrant population.

Methods
This study utilizes the mandatory retirement age system as an exogenous shock within a fuzzy regression discontinuity (FRD) experimental design to investigate the influence of parents’ retirement on the fertility intentions of their migrant offspring and potential mechanisms.

Results
The research findings indicate that parents’ retirement significantly reduces the fertility intentions of the migrant population by 34.4%. Mechanism analysis attributes this adverse effect to the reduction in intergenerational wealth transfer due to parent’s retirement. As the family’s economic situation worsens, the negative impact of retirement on fertility intentions becomes more pronounced. The childcare support mechanism provided by retired grandparents can partially offset the adverse effects of the income mechanism.

Conclusions
This study provides recommendations for enhancing policies related to delaying retirement age and childcare.
A security analysis of two classes of RSA-like cryptosystems
Authors: Cotan Paul , Teşeleanu George 
Published: September 2024

Abstract
Let

N
=
p
q

N=pq

be the product of two balanced prime numbers

p

p

and

q

q

. In Elkamchouchi et al. (Extended RSA cryptosystem and digital signature schemes in the domain of Gaussian integers. In: ICCS 2002. vol. 1. IEEE Computer Society; 2002. p. 91–5.) introduced an Rivest-Shamir-Adleman (RSA)-like cryptosystem that uses the key equation

e
d
−
k

(

p

2

−
1

)

(

q

2

−
1

)

=
1

ed-k\left({p}^{2}-1)\left({q}^{2}-1)=1

, instead of the classical RSA key equation

e
d
−
k

(

p
−
1

)

(

q
−
1

)

=
1

ed-k\left(p-1)\left(q-1)=1

. Another variant of RSA, presented in Murru and Saettone (A novel RSA-like cryptosystem based on a generalization of the Rédei rational functions. In: NuTMiC 2017. vol. 10737 of Lecture Notes in Computer Science. Springer; 2017. p. 91–103), uses the key equation

e
d
−
k

(

p

2

+
p
+
1

)

(

q

2

+
q
+
1

)

=
1

ed-k\left({p}^{2}+p+1)\left({q}^{2}+q+1)=1

. Despite the authors’ claims of enhanced security, both schemes remain vulnerable to adaptations of common RSA attacks. Let

n

n

be an integer. This article proposes two families of RSA-like encryption schemes: one employs the key equation

e
d
−
k

(

p

n

−
1

)

(

q

n

−
1

)

=
1

ed-k\left({p}^{n}-1)\left({q}^{n}-1)=1

for

n
>
0

n\gt 0

, while the other uses

e
d
−
k

[

(

p

n

−
1

)

(

q

n

−
1

)

]

⁄

[

(

p
−
1

)

(

q
−
1

)

]

=
1

ed-k\left[\left({p}^{n}-1)\left({q}^{n}-1)]/\left[\left(p-1)\left(q-1)]=1

for

n
>
1

n\gt 1

. Note that we remove the conventional assumption of primes having equal bit sizes. In this scenario, we show that regardless of the choice of

n

n

, continued fraction-based attacks can still recover the secret exponent. Additionally, this work fills a gap in the literature by establishing an equivalent of Wiener’s attack when the primes do not have the same bit size.
Race, Nation Building, and the Global Cold War: Mestizaje in Mexico’s 1968 Olympic Games
Authors: Elías Jiménez Axel G. 
Published: September 2024

Abstract
Mexico City hosted the Summer Olympic Games in 1968. Scholarship has focused on intended economic outcomes that the Mexican government pursued; nevertheless, few scholars have looked at how organizers depicted the nation in terms of race during this period of global attention. This article uses archival documents, official publications, the press, and static and moving images to analyze how Mexican organizers planned the Olympic Games and used racialized representations while trying to position Mexico as a modern global leader. Organizers followed Olympic protocols and the expectations of being an Olympic host; they signposted proximity to Europe and the North Atlantic, and used miscegenation (mestizaje) as part of their strategies. The messages reached millions of people around the world, coinciding chronologically with anti-imperial and anti-racist struggles. The article suggests that IOC protocols such as the torch relay, and the opening and closing ceremonies have shaped representations of host cities and nations, particularly those not often associated with European countries.
The multilingual repertoire of the Haitian community in Chapecó (SC, Brazil): Patterns of linguistic evolution in a South–South migration context
Authors: Gutiérrez Maté Miguel 
Published: September 2024

Abstract
This article provides an initial sociolinguistic and structural characterization of the multilingual repertoire of the Haitian migrant community in Chapecó, Santa Catarina, Brazil, based on a corpus of interviews I compiled myself. The focus is primarily on two languages from the repertoire, French and Spanish, which I consider ‘forgotten’ in two senses. First, in a scholarly context, since studies in migration linguistics often pay less attention to languages that are neither the in-group language of the migrant population (in this case, Haitian Creole) nor the main language of the host country (in this case, Portuguese); indeed, French is the official, post-colonial language used by the social elites in the homeland, while Spanish is the language of a first country of migration (the Dominican Republic) for some Haitians before their current migration to Brazil. Second, at the cognitive level, because although these languages are part of the speakers’ experiential baggage, they are seldom actively spoken in the new Brazilian context. Lastly, the article highlights how speakers efficiently utilize the different languages in their repertoire, giving rise to contact-induced linguistic features (which, following traditional criteria, are classified here as the result of transfer or borrowing).
The vowel space of multiethnolectal (Stuttgart) German
Authors: Duran Daniel , Auer Peter 
Published: October 2024

Abstract
The emergence of multiethnolects, i.e. specific speaking styles or varieties associated with second and third generation speakers from immigrant backgrounds, has been observed and studied in several major cities in Europe and elsewhere in the world. The multiethnolect that is the focus of this study is one such variety of colloquial German. Most previous research on multiethnolectal German has focused on grammatical features. This paper reports on the first comprehensive study of the vowel system (vowel quality and global vowel space size) of multiethnolectal German, based on data from Stuttgart. The results show that the vowel space of multiethnolectal speakers is in generally more centralized than that of a comparison group. A more detailed analysis reveals that the linguistic background plays an important role, as speakers with a Turkish or South Slavonic language background are responsible for this effect.
Living wills vis a vis right to die
Authors: Gambhir Singh O. , Ray Navneet , Apsarin Jamim , Meher Hardik Kumar 
Published: September 2024

The word “Euthanasia” relates to two different words from the Greek language “Eu" which indicates "good" and "Thanatosis" which indicates "death”, suggesting a “satisfactory Death” or “easy and painless Death” The phrase “mercy killing” has become associated with this meaning. It comprises inflicting painless death on a person suffering from an incurable and dreadful illness. It’s the practice of terminating a person’s life by administering a lethal injection or ceasing medical treatment. Informed and shared decision‑making between the patient and the health professional caring for him or her is crucial for the quality of care and its outcomes. Living wills are nothing more than a tangible representation of this truth. As a result of their legal approval, patients’ autonomy has been recognized. However, there are some differences in the regulations that have been adopted, and the health practice linked with these documents raises a number of practical and ethical questions that should be considered.Living-will is a written statement depicting individuals’ directions regarding future medical treatment in situations in which they are no longer able to express informed consent. Based on the secondary literature and substantiated with empirical findings, it carves out the need for death preparedness in general and endorsing living-will in particular. The paper covers the prevailing legislations and legal measures permitting passive euthanasia in different countries including India. It further entails all the essential requisites for writing a ‘living-will’ incorporating all the procedures and steps needed to be followed.A thorough assessment of the current accessible literature on living will has been conducted, just to focus on the knowledge of euthanasia in detail. Most importantly, the social impact of the concept of euthanasia needs to be understood by the society. Moreover, it must be considered that euthanasia is different from suicide. Few communities may show the interference of their religion with euthanasia. So it is essential to enlighten the idea of euthanasia in legal ways for different countries.
Death of a serving soldier by an unusual weapon – A case report
Authors: Kiranmai Kemsaram , Narayana M Laxmi 
Published: September 2024

According to the witnesses, crime scene and inquest report, deceased is a 30 years old serving male soldier who was riding bike, accidentally got cut through neck by Chinese Manja and suddenly collapsed near langerhouse flyover at around 18:25 PM and was brought dead to Military Hospital, Golconda at 18;40 PM. The corpse of the deceased was brought to Mortuary, Osmania General Hospital at 09;00 PM on 13/01/2024 by the Investigation Officer and requested for postmortem examination under section 174 Criminal Procedure Code. The postmortem findings were an antemortem horizontally cut throat injury at the level of thyroid cartilage in the front of neck. The structures underlying are exposed with transection of external carotid arteries and internal jugular veins on both sides of neck and trachea is transected at the level of 4 cartilaginous ring. Margins are clean cut with inverted edges, tapering is seen on left side with blunt end towards right, with meticulous crime scene investigation and post mortem examination and interpretation of the findings cause of death was given as “”
Chondrolipoma of the knee in a child: A case report
Authors: Khan Pervaiz Ahmed , Bhonsle Vaishali S , Sampat Nakul Y , Chekuri Pradeep , Sisodia Karan R 
Published: September 2024

Chondrolipoma is a rare benign mesenchymal tumor characterized by the presence of cartilage and mature adipose tissue. Typically affecting adults in regions like the buccal and breast, chondrolipomas in pediatric patients are exceedingly uncommon. This case presents a unique instance of a 15-year-old boy diagnosed with a chondrolipoma in his knee joint, marking the first reported case of such a tumor in a child's knee. Given the rarity of this presentation and the absence of similar reports in the literature, this case report holds significant clinical importance. The patient, a 15-year-old boy, presented with a benign tumor in his knee joint, a location not previously associated with chondrolipomas. The decision to forego further follow-up testing was made based on the benign nature of the tumor and the absence of immediate clinical concerns. The patient was discharged with instructions for monitoring and to report any signs of recurrence. This case highlights the atypical manifestation of chondrolipoma in a pediatric knee, emphasizing the need for vigilance in diagnosing uncommon benign lesions in younger patients. Reporting the second documented case of a chondrolipoma in a child's knee underscores the diagnostic challenges posed by rare tumors with non-typical presentations. The difficulty in diagnosing such lesions based solely on radiological findings is highlighted, emphasizing the importance of histological examination for accurate diagnosis. While acknowledging the limited follow-up period at the time of publication, this case report aims to raise awareness among clinicians regarding the potential occurrence of chondrolipomas in pediatric populations. By shedding light on this unusual diagnosis, this report contributes to the broader understanding of benign mesenchymal tumors and underscores the significance of considering rare entities in the differential diagnosis of pediatric joint tumors.
The Effect of Learning Environment on Language Acquisition:A Survey of Chinese and Pakistani Siblings
Authors: Akram Muhammad Adeel , Wang Hongyan , Mustafa Iqra 
Published: September 2024

First Language Acquisition is a complex phenomenon and it has been debated for decades by theorists and researchers. The biological foundations of language such as Chomsky’s LAD and the obvious influence of external stimuli have resulted in many different schools of thought for language acquisition. This paper explores different theories of language acquisition and presents their features as well as their criticisms. It also outlines the differences between acquisition and learning, and presents the stages of language acquisition. This study’s primary aim is to explore what role nurture plays in the early stages of development of language. The researcher would explore this question by conducting a survey based on the time of onset of speech in the siblings’ first language. This survey is being conducted because siblings get the same kind of environment but the younger siblings have a comparatively more favorable language environment as they get the stimulus from the parents as well as their elder siblings. The researcher has done a comparative survey on the onset of speech between the siblings and analyzed the results to draw the conclusion of this paper. The researcher has systematically collected data from language learning schools in China and Pakistan. Data is gathered from 100 parents of the children who have more than one child and are learning second language in an institution. Out of the 100 participants, 52 were Chinese and 48 were Pakistanis. Quantitative method of research is adopted for analyzing the data collected in the survey. Questionnaire is used as a data collection tool which consists of open-ended and close-ended questions. Later in analysis section, data is comprehensively examined and investigated. Earlier onset of speech in first child and second child was analyzed in which the ratio is 31% and 69% respectively and out of 100 participants only 8% of the siblings had same time of onset of speech. Research shows that earlier onset of speech results comprised of 56% of girls as compared to 44% of boys. Research on language learners through their parents’ feedback concludes that both nature and nurture play an important role in the development of language acquisition. This is because we need our genes and brain to build a language acquisition device (LAD), and then, after we have the ability to learn a language and interact with people around us, we gradually acquire words and grammar, and our language system is then complete.
JAVANESE CALENDAR CALCULATION AND FATE DETERMINATION:
Authors: Fauziyah Dwi , Naldo Jufri , Siregar Husna Sari 
Published: September 2024

The Javanese calendar is a calendar that contains complete market days that have certain values or meanings called neptu. The people of Aek Raso village are people who consider the day as something sacred, especially the day on which a person was born. Because the day on which a person was born is used for various calculations of a desire or desire, such as determining a mate, marriage, circumcision and searching for lost items. The purpose of this study is to analyse how Javanese calculation beliefs and fate determinants. Descriptive method, data collection techniques used are observation techniques, literature, interviews and documentation. The analysis technique used is qualitative method. The result of the analysis of this research is that the people of Aek Raso village, Torgamba sub- district, Labuhanbatu Selatan Regency still believe or uphold the tradition in the calculation of the Javanese calendar in determining life. Some people believe in the truth of calendar calculations and still practice them. It can be said that some people want to have a better life. Local people say that they respect and will continue to preserve the traditions inherited from their ancestors. However, the community considers the calculation of the Javanese calendar as just a tradition and not as worship.
Trombólisis con guía ecocardiográfica en un paciente con tromboembolismo pulmonar masivo y arresto cardiopulmonar. Reporte de caso
Authors: Zegarra Piérola Jaime Wilfredo , Ticona Salazar José , Lévano Díaz Lady , Umezawa Makikado Luis , Campos Muñoz Roberto 
Published: September 2024

El tromboembolismo pulmonar (TEP) masivo, es un evento vascular agudo caracterizado por choque obstructivo, con mortalidad alta. El objetivo del reporte fue resaltar la terapia de trombólisis con guía ecocardiográfica en un paciente con tromboembolismo pulmonar (TEP) masivo y arresto cardiopulmonar. Se presenta el caso de un varón de 48 años de edad, con fractura expuesta de tibia izquierda no operada, hospitalizado sin uso de heparina profiláctica, quién cursó con disnea súbita, dolor torácico y arresto cardiopulmonar dos veces, el primero en hospitalización general, y el segundo al ingreso a la unidad de cuidados intensivos (UCI). Post retorno de la circulación espontanea cursó con hipotensión, taquicardia, hipoxemia, Glasgow 4 puntos; en el electrocardiograma se encontró taquicardia sinusal, patrón S1Q3T3, bloqueo completo de rama derecha; en la ecocardiografía relación ventrículo derecho/ventrículo izquierdo >1, signo de McConell (+), desplazamiento del septum interventricular; excursión sistólica del anillo tricúspideo 10 mm, vena cava inferior 23 mm con colapso < 50%; recibió noradrenalina y vasopresina a dosis altas, trombólisis con activador de plasminógeno tisular recombinante 100 mg; con monitoreo ecocardiográfico secuencial, logrando estabilización cardiopulmonar y resolución del choque obstructivo, con retiro del soporte y posterior alta de UCI y del hospital.