bluuebunny/crossref_metadata_2025_split huggingface dataset:
Edukasi Pencegahan Anemia pada Masa Kehamilan sebagai Upaya Meningkatkan Pengetahuan Ibu Hamil
Authors: R Maria Magdalena Saragi , Doloksaribu Tiurlan Mariasima , Yusniar Yusniar 
Published: September 2024

ABSTRAK Anemia memberikan dampak negatif terutama bagi bayi dalam kandungan, seperti mengakibatkan keguguran, bayi lahir tidak cukup bulan, bayi tidak berkembang sempurna. Anemia dianggap sebagai masalah kesehatan masyarakat yang utama pada lebih dari 80% negara di dunia, prevalensi anemia pada kehamilan >20%. Pengabdian kepada masyarakat dilakukan dalam bentuk edukasi pada ibu hamil berjumlah 30 orang. Tujuan Pengabdian Kepada Masyarakat ini adalah untuk mewujudkan pengabdian kepada masyarakat sebagai salah satu kegiatan Tri Darma Perguruan Tinggi, meningkatkan pengetahuan Ibu hamil tentang anemia sebagai upaya pencegahan anemia. Dari hasil evaluasi diperoleh pengetahuan ibu hamil sebelum diberikan edukasi mayoritas cukup sebanyak 63,3% dan setelah dilakukan edukasi mayoritas baik sebanyak 95.7%. Dengan adanya kegiatan Pengabdian Kepada Masyarakat ini diharapakan kepada Ibu hamil dapat meningkatkan pengetahuan mengenai anemia sebagai upaya pencegahan anemia pada ibu hamil. Kata Kunci: Edukasi, Pengetahuan, Ibu Hamil ABSTRACT Anemia has a negative impact, especially on babies in the womb, such as resulting in miscarriage, babies born not at term, babies not developing fully. Anemia is considered a major public health problem in more than 80% of countries in the world, the prevalence of anemia in pregnancy is >20%. Community service was carried out in the form of education for 30 pregnant women. The aim of this Community Service is to realize community service as one of the Tri Darma activities of higher education, increasing pregnant women's knowledge about anemia as an effort to prevent anemia. From the evaluation results, it was found that the majority of pregnant women's knowledge before being given education was adequate at 63.3% and after education the majority was good at 95.7%. With this Community Service activity, it is hoped that pregnant women can increase their knowledge about anemia as an effort to prevent anemia in pregnant women. Keywords: Education, Knowledge, Pregnant
Non Alcoholic Fatty Liver Disease: A Silent Global Epidemic
Authors: Shil Bimal Chandra , Uddin Mohammad Kamal , Hasan Monirul 
Published: September 2024

Nonalcoholic fatty liver disease (NAFLD) is a common liver disease worldwide affecting adult as well as children with an increasing prevalence. It is associated with insulin resistance and frequently occurs with features of the metabolic syndrome. NAFLD is a spectrum, with NAFL (Non-alcoholic fatty liver) being the initial mildest form, NASH and cirrhosis is being at the other end of the spectrum. Mostly NAFLD is asymptomatic but may present with elevated liver enzyme levels to cirrhosis with its complications and hepatocellular carcinoma. Standard ultrasound including elastography may be used to detect steatosis. Though, liver biopsy is the gold standard for diagnosis of NAFLD but it is not frequently performed. NAFLD patients with evidence of nonalcoholic steatohepatitis and advanced fibrosis are at increased risk of adverse outcomes, including overall mortality. Life style modification and weight loss remains the cornerstone of the management of NAFLD. There are no approved pharmacological drugs for the treatment of NAFLD till now. Although several promising drugs are on the horizon, more trials are needed to validate these medications.
Bangladesh J Medicine 2023; 34(2): 73-79
DESIGNING TAX ME SERVICE APPLICATIONS IN TAX CONSULTING
Authors: Joosten Joosten , Halim Fandi , Arianto Jennifer , Yulinda Cindy 
Published: September 2024

Abstract: "Tax Me" is an application engaged in tax consulting services that is run through a mobile platform. The problems that are often faced by the public, especially taxpayers, are difficulties in choosing reliable and trusted tax consultants because many tax consultants embezzle money and slow down the tax reporting process, as well as the lack of knowledge of taxpayers about all tax regulations, a complicated and frequently changing tax system, and also there are still negative public assumptions about taxes such as corruption in taxes that have been paid by taxpayers. The "Tax Me" application was developed using the System Development Life Cycle (SDLC) system development methodology. This application was developed as a forum for tax consulting services in collaboration with the Directorate General of Taxes (DGT) institution which is able to provide transparent and reliable tax consulting services. "Tax Me" is expected to be able to provide education to taxpayers, overcome taxpayers' concerns about the tax calculation and reporting process as well as in choosing a tax consultant who can be trusted. In addition, several features of the "Tax Me" application such as: NPWP, Tax Calculation, Tax Consultation, Report & Check Annual Tax Return, E-Billing & Pay Tax, Tax Reminder and Tax Article. Keywords: directorate general of taxes (DJP); tax; tax me; taxpayer Abstrak: “Tax Me” adalah aplikasi yang bergerak pada bidang pelayanan konsultasi pajak yang dijalankan melalui platform mobile. Masalah yang sering dihadapi oleh masyarakat khususnya Wajib Pajak adalah kesulitan dalam memilih konsultan pajak yang dapat diandalkan dan dipercaya karena banyak konsultan pajak yang menggelapkan uang dan memperlambat proses pelaporan pajak, serta kurangnya pengetahuan Wajib Pajak mengenai segala peraturan perpajakan, sistem perpajakan yang rumit dan sering berubah, dan juga masih ada anggapan negatif masyarakat tentang pajak seperti korupsi atas pajak yang telah dibayarkan oleh Wajib Pajak. Aplikasi “Tax Me” dikembangkan dengan menggunakan metodologi pengembangan sistem System Development Life Cycle (SDLC). Aplikasi ini dikembangkan sebagai wadah layanan konsultasi perpajakan yang bekerja sama dengan lembaga Direktorat Jenderal Pajak (DJP) yang mampu memberikan layanan konsultasi perpajakan yang transparan dan terpercaya. “Tax Me” diharapkan mampu memberikan edukasi kepada Wajib Pajak, mengatasi kekhawatiran Wajib Pajak terhadap proses perhitungan dan pelaporan pajak juga dalam memilih konsultan pajak yang dapat di percaya. Disamping itu, beberapa fitur dari aplikasi “Tax Me” seperti: NPWP, Hitung Pajak, Konsultasi Pajak, Lapor & Periksa SPT Tahunan, E-Billing & Bayar Pajak, Pengingat Pajak dan Artikel Pajak. Kata kunci: direktorat jenderal pajak (DJP); pajak; tax me; wajib pajak
MAPPING SYSTEM FOR LOCATION OF STUNTING CASES IN TODDLER IN TANJUNG BALAI CITY USING WEBGIS
Authors: Alfa Zikri , Yusda Riki Andri , Rahayu Elly 
Published: September 2024

Abstract: Data on stunting cases among toddlers in Datuk Bandar Timur sub-district, Tanjung Balai city Not yet processed in a way computerized use digital map , so that the monitoring process in-depth investigation of the distribution and patterns of stunting in a area Not yet presented with Good . This matter Of course impact on cadre Public health center Semula Jadi For monitor number nutrition bad And spread prevalence of stunting in Datuk Bandar Timur sub-district, Tanjung Balai city . For That need development A system internal data management form chart nor map that can be give description spread nutrition bad in the region Mayor. Planning And development system information This done with use method data collection and interview direct to the UPTD Community Health Center Semula Jadi . Objective it was built this webgis can assist in identifying areas that need nutritional intervention, mapping the prevalence of stunting and malnutrition, as well as monitoring nutrition programs and optimizing resource allocation. Results from GIS can plays an important role in supporting efforts to prevent and overcome stunting problems by providing tools effective software for collecting, analyzing and visualizing nutritional data spatially. The use of web GIS can also provide information on stunting locations from UPTD Semula Jadi Health Center data.Keywords : geographic information system; location mapping system; stunting. Abstrak: Data kasus stunting pada balita di kecamatan datuk bandar timur kota tanjung balai belum diproses secara terkomputerisasi menggunakan peta digital, sehingga proses pemantauan penyelidikan mendalam tentang sebaran dan pola stunting disuatu daerah belum tersajikan dengan baik. Hal ini tentu berdampak pada kader puskesmas Semula Jadi untuk memantau angka gizi buruk dan penyebaran prevalensi stunting di kecamatan datuk bandar timur kota tanjung balai. untuk itu perlu pembangunan sebuah sistem pengelolaan data dalam bentuk grafik maupun peta yang dapat memberikan gambaran penyebaran gizi buruk diwilayah Datuk Bandar. Perancangan dan pembangunan sistem informasi ini dilakukan dengan menggunakan metode pengambilan data dan wawancara langsung ke UPTD Puskesmas Semula Jadi. Tujuan dibangunnya webgis ini dapat membantu dalam identifikasi daerah yang membutuhkan intervensi gizi, pemetaan prevalensi stunting dan gizi buruk, serta memantau program-program gizi dan optimalisasi alokasi sumber daya. Hasil dari SIG dapat berperan penting dalam mendukung upaya pencegahan dan penanggulangan masalah stunting dengan menyediakan alat software yang efektif untuk pengumpulan, analisis, dan visualisasi data gizi secara spasial. Kegunaan webgis juga dapat memberikan informasi mengenai lokasi stunting dari data UPTD Puskesmas Semula Jadi.Kata kunci: sistem informasi geografis; sistem pemetaan lokasi; stunting
Patients-Reported Outcomes of Acute Side Effects During Head and Neck Cancer Radiotherapy: A Cross-Sectional Study at Andalas University Hospital Padang
Authors: Ismail Fikri Wahyuda , Rafli Rhandyka , Putriyuni Anandia 
Published: September 2024

Background: Head and neck cancer is a malignancy originating from the upper aerodigestive tract. Head and neck cancer patients undergoing radiotherapy using brachytherapy, 2DRT, 3CDRT, and IMRT techniques. Patients undergoing radiotherapy will experience several acute side effects consisting of mucositis, dysphagia, xerostomia, and dermatitis. This is influenced by the technique and dose given. This study aims to grade and time the acute side effects of radiotherapy for head and neck cancer at the Andalas University Hospital Padang. Methods: A quantitative descriptive method with a cross-sectional approach is used. Secondary data with a total sample of 88 patients. This research uses medical record data and is analyzed using statistical analysis methods. Results: This study found that the most head and neck cancer patients who underwent radiotherapy were male 57 (64.8%) patients, nasopharyngeal subsite 41 (46.6%) patients with non-keratinizing nasopharyngeal carcinoma 32 (36.4%) patients. The most common radiotherapy technique for head and neck cancer was IMRT in 58 (65.9%) patients with a dose of 61-70 Gy in 78 (88.6%) patients and the most common stage was IV A in 51 (58%) patients. Patients did not undergo chemotherapy treatment in 51 (58%) and surgery in 69 (78.4%). Body mass index (BMI) before radiotherapy was normal in 74 (84.1%) patients and after radiotherapy became underweight in 57 (64.8%) patients resulting in weight loss 1 kg in 83 (94.3%) patients. The highest grade of radiotherapy side effects was grade 1 which consisted of mucositis 84 (95.5%), dysphagia 83 (94.3%), xerostomia 78 (88.6%), and dermatitis 78 (88.6%) patients. The most frequent timing of mucositis side effects occurred in the 3rd week in 40 (45%) patients, dysphagia in the 3rd week in 41 (47%) patients, xerostomia in the 3rd week in 33 (38%) patients, and dermatitis at week 6 in 24 (27%) patients. Conclusions: Patients with head and neck cancer who undergo radiotherapy from week 1 to week 7 will experience side effects, including mucositis, dysphagia, xerostomia, and dermatitis. The average side effect appears in the 3rd week with grade 1.
Descriptive Analysis of CT Scan Findings in Breast Cancer Patients with Bone Metastases in Universitas Andalas Hospital Radiotherapy Installation
Authors: Yusriono Irfan , Tri Septiana Vina , Rafli Rhandyka 
Published: September 2024

Background: Breast cancer is experiencing the most significant increase in cases among all cancers worldwide. Approximately 65% to 75 % of advanced breast cancer patients will experience bone metastases. CT scan is the most affordable and accessible method for evaluating bone metastases. This study aims to describe the characteristics of CT scan examination of bone metastases in breast cancer patients in the radiotherapy installation at Universitas Andalas Hospital from 2019 until 2021. Methods: A total of 51 patients with breast cancer who had bone metastases were included in this quantitative descriptive study, using a total sampling approach. The clinical data was taken from the medical records at the radiotherapy installation at Andalas University Hospital. The collected data was processed and analyzed using SPSS statistical software. Results: Based on the results, the mean age of patients was 49 years. The most histopathological type was invasive carcinoma mammae of no special type (57%). The most common site for bone metastases is osteo vertebrae (35%). Mixed lesions were the most frequent bone metastatic finding (51%), with fractures occurring in 27% of cases. Conclusions: The results of this study are breast cancer with bone metastases occurring on average at the age of 49 years, histopathological type the most is invasive carcinoma mammae of no special type. Breast cancer with bone metastases is most common in Osteo Vertebrae with mixed lesions as well as pathological fracture with a low percentage.
Novel spirooxindole-triazole derivatives: unveiling [3+2] cycloaddition reactivity through molecular electron density theory and investigating their potential cytotoxicity against HepG2 and MDA-MB-231 cell lines
Authors: Shawish Ihab , Al Ayoubi Samha , El-Faham Ayman , Aldalbahi Ali , El-Senduny Fardous F. , Badria Farid A. , Ríos-Gutiérrez Mar , Hammud Hassan H. , Ashraf Sajda , Ul-Haq Zaheer , Barakat Assem 
Published: September 2024

A novel analogue of hybrid spirooxindoles was synthesized employing a systematic multistep synthetic approach. The synthetic protocol was designed to obtain a series of spirooxindole derivatives incorporating triazolyl-s-triazine framework via [3 + 2] cycloaddition (32CA) reaction of azomethine ylide (AY) with the corresponding chalcones (6a-d). Unexpectedly, the reaction underwent an alternate route, leading to the cleavage of the s-triazine moiety and yielding a series of spirooxindole derivatives incorporating a triazole motif. A comprehensive investigation of the 32CA reaction mechanism was conducted using Molecular Electron Density Theory (MEDT). The viability of all compounds was evaluated through an MTT assay, and the IC50 values were determined using Prism Software. The antiproliferative efficacy of the synthesized chalcones and the corresponding spirooxindole derivatives was assessed against two cancer cell lines: MDA-MB-231 (triple-negative breast cancer) and HepG2 (human hepatoma). These findings were compared with Sorafenib, which was used as a positive control. The results revealed that chalcones (6c and 6d) were the most active among the tested chalcones, with IC50 values of 7.2 ± 0.56 and 7.5 ± 0.281 µM for (6c) and of 11.1 ± 0.37 and 11.0 ± 0.282 µM for (6d), against MDA-MB-231 and HepG2, respectively. Spirooxindoles (9b, 9c, 9h, and 9i) exhibited the highest activity with IC50 values ranging from 16.8 ± 0.37 µM to 31.3 ± 0.86 µM against MDA-MB-231 and 13.5 ± 0.92 µM to 24.2 ± 0.21 µM against HepG2. In particular, spirooxindole derivatives incorporating 2,4-dichlorophenyl moiety were the most active, with an IC50 of 16.8 ± 0.37 µM for (9h) against MDA-MB-23 and 13.5 ± 0.92 µM for (9i) against HepG2. Interestingly, the IC50 of compound (6c) (7.2 µM) exhibited better activity than that of Sorafenib (positive control) (9.98 µM) against MDA-MB-231. Molecular docking, ADMET, and molecular dynamic simulations were conducted for the promising candidates (6b, 6c, and 9h) to explore their binding affinity in the EGFR active site.
Risk factors for postoperative DVT exacerbation or new DVT in patients with spinal cord injury complicated with cervical fracture
Authors: Wang Haiying , Lv Bing , Li Wei , Xu Jingjing , Ma Ce 
Published: September 2024

ObjectiveTo investigate the dynamic changes of perioperative deep venous thrombosis (DVT) in patients with spinal cord injury complicated with cervical fracture and analyze the risk factors of postoperative DVT exacerbation or new DVT.MethodsFrom January 2018 to December 2023, a total of 232 patients with spinal cord injury complicated with cervical fracture in our hospital were retrospectively analyzed. Ultrasonography of both lower limbs was performed before and after surgery. According to whether there was aggravation of DVT or new thrombosis, the group was divided into DVT exacerbation or new DVT group and non-DVT exacerbation group. Clinical data were used to study the dynamic changes of perioperative DVT. Logistic regression analysis and receiver operating characteristic (ROC) curve were used to explore the risk factors.ResultsThe DVT was found in 47 patients before surgery, including 26 cases of distal thrombus, 14 cases of mixed thrombus and 7 cases of proximal thrombus. Postoperative DVT increased to 81, including 31 distal thrombus, 35 mixed thrombus and 15 proximal thrombus. A total of 53 patients (22.8%, 53/232) experienced postoperative DVT exacerbation or new DVT. Logistic regression analysis revealed that age, American Spinal Injury Association (ASIA) score, time from injury to surgery, surgery time and blood loss were risk factors for postoperative DVT exacerbation.ConclusionsIn patients with spinal cord injury complicated with cervical fracture, the risk of postoperative DVT exacerbation is very high. Age, ASIA score A-B, time from injury to surgery, surgery time and blood loss were risk factors for postoperative DVT exacerbation or new DVT.
The association of physical activity with kidney function risk among adults with long working hours
Authors: Yan Tenglong , Nabi Subat , Liu Xiaodong , Zeng Bangzhao , Song Xin , Ding Xiaowen , Hu Binshuo 
Published: September 2024

IntroductionLong working hours are likely associated with the decreased of kidney function, while physical activity (PA) was linked to improvements in kidney function. However, whether PA can offset the negative impact of long working hours on kidney function was unclear, which is the focus of this study.MethodsA cross-sectional study was conducted. Three approaches were adopted to distinguish the association between long working hours and regular working hours. Moderate to vigorous physical activity (PA) was assessed by a structured questionnaire. eGFR and chronic kidney disease (CKD) or not were utilized to evaluate the kidney function. Linear and logistic regression analyses were conducted to assess the association between weekly working hours, PA, and kidney function.ResultsA total of 18,431 adults were enrolled in this study, including 9981 males (54.2%) and 8450 females (45.8%). The average eGFR was (99.54 ± 17.55 mL/min/1.73 m2). The people worked more than 40 h/wk (98.89 ± 17.06 mL/min/1.73 m2) had lower eGFR compared to those worked less than 40 h/wk (99.93 ± 17.83 mL/min/1.73 m2) (p &lt; 0.05). Individuals working longer hours exhibited lower eGFR (β = -0.772, 95% CI: -1.241, -0.303, for &gt; 40 h/wk compared to working ≤ 40 h/wk). Engagement in moderate to vigorous PA was associated with higher eGFR values (β = 1.159, 95% CI: 0.699, 1.619) compared to low PA (&lt; 150 minutes/wk), but this association did not reach statistical significance for the prevalence of CKD. Furthermore, PA was insufficient to reverse the decline of eGFR related to prolonged working hours.DiscussionProlonged working hours were associated with a decline in eGFR, while PA was found to have a protective effect on kidney function. However, PA alone may not fully mitigate the negative impact of prolonged working hours on renal health. More robust measures to protect renal function should be implemented to mitigate the damage caused by prolonged working hours.
The role of anatomical and functional orientation in identification of parathyroid glands for patients with parathyroidectomy
Authors: Zhou Peng , Xu Jing , Guo Yinghao , Chen Lanqing , Liu Yongxiang , Guo Haonan , Shao Changxiu , He Qingqing 
Published: September 2024

ObjectiveTo investigate diagnostic approaches for preoperative localization of secondary hyperparathyroidism, as well as to give surgeons with precise parathyroid gland localization and imaging so that surgery can be performed safely.MethodsThe clinical data of 710 patients with secondary hyperparathyroidism who underwent surgery in our center from October 2009 to October 2023 were retrospectively analyzed. The changes in calcium, phosphorus, and parathyroid hormone levels were observed to ascertain the anatomical location and number of parathyroid glands.ResultsAmong the 710 patients, 55 underwent total parathyroidectomy, the others underwent total parathyroidectomy with autotransplantation. In total, 2,658 parathyroid glands were removed, with 43 glands being removed in 35 reoperation cases. The median parathyroid hormone level at 6 months postoperatively was 13.40 (interquartile range, 7.00-29.80) pg/mL. The detection rates of the parathyroid glands before first and repeat surgeries were higher using 99mTc-MIBI SPECT/CT fusion imaging than ultrasound (P&lt;0.05). The sensitivity of combined preoperative 99mTc-MIBI SPECT/CT and ultrasound was 92.31%, higher than that of either 99mTc-MIBI SPECT/CT fusion imaging or ultrasound alone (P &lt; 0.05). The incidence of ectopic parathyroid glands was 23.8%, and the incidence of ectopic left lower parathyroid glands was 13.2%. The left lower parathyroid gland was the most prone to ectopia.Conclusion99mTc-MIBI SPECT/CT fusion imaging, paired with high-frequency ultrasound, can be utilized to diagnose SHPT preoperatively. The most common ectopia site is the left lower parathyroid gland, which is located primarily in the thymus and superior mediastinum. Understanding the functional anatomical distribution of the parathyroid glands is critical for developing effective surgical methods for secondary hyperparathyroidism.