bluuebunny/crossref_metadata_2025_split huggingface dataset:
Once a clinician, always a clinician: a systematic review to develop a typology of clinician-researcher dual-role experiences in health research with patient-participants
Authors: Hay-Smith E. Jean C. , Brown Melanie , Anderson Lynley , Treharne Gareth J. 
Published: August 2016

AbstractBackgroundMany health researchers are clinicians. Dual-role experiences are common for clinician-researchers in research involving patient-participants, even if not their own patients. To extend the existing body of literature on why dual-role is experienced, we aimed to develop a typology of common catalysts for dual-role experiences to help clinician-researchers plan and implement methodologically and ethically sound research.MethodsSystematic searching of Medline, CINAHL, PsycINFO, Embase and Scopus (inception to 28.07.2014) for primary studies or first-person reflexive reports of clinician-researchers’ dual-role experiences, supplemented by reference list checking and Google Scholar scoping searches. Included articles were loaded in NVivo for analysis. The coding was focused on how dual-role was evidenced for the clinician-researchers in research involving patients. Procedures were completed by one researcher (MB) and independently cross-checked by another (JHS). All authors contributed to extensive discussions to resolve all disagreements about initial coding and verify the final themes.ResultsDatabase searching located 7135 records, resulting in 29 included studies, with the addition of 7 studies through reference checks and scoping searches. Two overarching themes described the most common catalysts for dual-role experiences – ways a research role can involve patterns of behaviour typical of a clinical role, and the developing connection that starts to resemble a clinician-patient relationship. Five subthemes encapsulated the clinical patterns commonly repeated in research settings (clinical queries, perceived agenda, helping hands, uninvited clinical expert, and research or therapy) and five subthemes described concerns about the researcher-participant relationship (clinical assumptions, suspicion and holding back, revelations, over-identification, and manipulation). Clinician-researchers use their clinical skills in health research in ways that set up a relationship resembling that of clinician-patient. Clinicians’ ingrained orientation to patients’ needs can be in tension with their research role, and can set up ethical and methodological challenges.ConclusionThe typology we developed outlines the common ways dual-role is experienced in research involving clinician-researchers and patient-participants, and perhaps the inevitability of the experience given the primacy accorded to patient well-being. The typology offers clinician-researchers a framework for grappling with the ethical and methodological implications of dual-role throughout the research process, including planning, implementation, monitoring and reporting.
Effective elliptic arc selection from connected edge points
Authors: Masuzaki Tomonari , Sugaya Yasuyuki 
Published: August 2016

Abstract
Extracting edge points from an image and fitting ellipses to them is a fundamental technique for computer vision applications. However, since the extracted edge points sometimes contain non-elliptic arcs such as line segments, it is a very difficult to extract only elliptic arcs from them. In this paper, we propose a new method for extracting elliptic arcs from a spatially connected point sequence. We first fit an ellipse to an input point sequence and segment the sequence into partial arcs at the intersection points of the fitted ellipse. Next, we compute residuals of the fitted ellipse for all input points and select elliptic arcs among the segmented arcs by checking the curvatures of the residual graph. Then, we fit an ellipse to the selected arcs and repeat the above process until the selected arcs do not change. By using simulated data and real images, we compare the performance of our method with existing methods and show the efficiency of our proposed method.
Wilson Disease
Authors: Pfeiffer Ronald F. 
Published: August 2016

ABSTRACT

Purpose of Review: This article reviews the clinical features of Wilson disease, focusing on the neurologic and psychiatric abnormalities, and addresses the diagnostic workup and treatment approaches to managing the disease.

Recent Findings: The list of known mutations causing Wilson disease continues to grow, but advances in genetic testing may soon make it feasible to routinely perform genetic testing on individuals suspected of having Wilson disease.

Summary: Wilson disease is a rare genetic disorder with protean manifestations that should be considered in the differential diagnosis of any individual presenting with unexplained neurologic, psychiatric, or hepatic dysfunction. Appropriate diagnostic testing should be expeditiously performed and treatment promptly initiated and maintained since failure to diagnose and treat Wilson disease will result in progressive and ultimately irreversible damage to the neurologic and other systems.
Acceleration: The (good) use of the magnifying glass
Authors: Iragüen Zabala Oihane 
Published: August 2016

The studies of Science, Technology and Society, called STS studies, explore and determine the impacts of Science and Technology on social structure and its influences in the techno-scientific development. There are few approaches done from artistic disciplines. They question the link between Technology and Art, between Technics and values. They emphasize how currently in this dialectical relationship the humanist view remains in the background and the Technics overlay. From the Philosophy of Science several questions appear: if the Technology is a knowledge o just a tool to reach the knowledge, if Technology is a “know how” or a “know what”. Nowadays we “know how” but we need to find out the “know what for”.Keywords: SCIENCE; TECHNOLOGY; CYBERCULTURE; ACCELERATION; TECHNICS Azelerazioa: luparen erabilera (egokia)LaburpenaZientzia, Teknologia eta Gizartea ikasketek, ZTG ikasketak deituak, zientzia eta teknologiaren eraginak aztertu eta zehazten dituzte gizarte egituran eta garapen teknozientifikoan. Ikasketa hauek diziplina ezberdinetatik teknokultura ikertzea dute helburu. Hurbilketa gutxi egin dira diziplina artistikoetatik. Hauek teknologia eta artearen lotura eztabaidatzen dute, teknika eta balioen artekoa. Dialektika honek bigarren mailan geratzeko daukan joera aztertzen dute, zernolako joera dagoen teknika gailentzean eta ikuspuntu humanista murriztean. Zientziaren Filosofía arloan gogoeta egiten dute: Teknologia ezagutza bat da edo ezagutzara ailegatzeko tresna soilik?, Teknologia “nola egiteko ezagutza” zehatza da edo “zer egiteko ezagutza”? Gaur egun, badakigu nola egin, baia zertarako egiten den ezagutzaren beharra nabarmentzen dute ikasketa hauek. Hitz gakoak: ZIENTZIA; TEKNOLOGIA; CIBERKULTURA; AZELERAZIOA; TEKNIKA Aceleración: el (buen) uso de la lupa ResumenLos estudios de Ciencia, Tecnología y Sociedad, llamados estudios CTS, exploran y determinan los impactos de la Ciencia y la Tecnología en la estructura social y las influencias en el desarrollo tecnocientífico. Estos estudios tratan de investigar la Tecnocultura desde diversas disciplinas. Existen escasas aproximaciones hechas desde las disciplinas artísticas. Éstas cuestionan el nexo entre la tecnología y el arte, entre la Técnica y los valores. Recalcan cómo actualmente en esta dialéctica queda en un segundo plano el enfoque humanista y se superpone la técnica. Desde la Filosofía de la tecnología se reflexiona si la Tecnología es un conocimiento o una herramienta para acceder a él, si la Tecnología es un “saber cómo” o un “saber qué”. Hoy en día se “sabe cómo” pero se recalca la necesidad de cuestionar acerca del “saber para qué”. Palabras clave: CIENCIA; TECNOLOGÍA; CIBERCULTURA; ACELERACIÓN; TÉCNICA
Ideological Chillout Mix: Uso de visualidad, energía y conectividad en las aplicaciones de los servicios de escucha de música en línea
Authors: Soria Martínez Verónica 
Published: August 2016

Por el uso que hacen de la visualidad, la energía y la conectividad, los servicios de escucha de música en línea pueden funcionar como dispositivos de uniformización social e ideológica. La visualidad de las aplicaciones, por medio de la fotografía y del diseño de la interfaz, se asocia con un énfasis en lo extramusical y en el momento del usuario. El continuo suministro de música, y los efectos que tienen sobre el comportamiento humano, hacen que se pueda hablar del concepto de energía en torno a estos servicios. Por último, la conectividad, por medio de funciones de red social incluidas en las propias aplicaciones, añade a estos servicios una dimensión social que abarca dinámicas de grupo y el uso de datos para predicciones de mercado. Este texto describe cómo estas tres vías definen cómo el usuario recibe la música que escucha y por tanto hacen de estas aplicaciones un ejemplo de interpasividad, que a su vez contribuye a una uniformización del gusto y del horizonte de posibilidades para el usuario.Palabras-clave: ESCUCHA; MERCANCÍA; TEORÍA CRÍTICA; UNIFORMIZACIÓN; INTERNET Ideological Chillout Mix: Use of visuality, energy and connectivity in the applications of online music servicesAbstractBecause of their use of visuality, energy and connectivity, online music services can work as devices for social and ideological standardization. The applications’ visuality, through photography and design interface, can be related to an emphasis on the extra-musical dimension and the moment of the user. The continuous supply of music, and its effect on human behavior, allow us to speak about the concept of energy in relation to these services. Lastly, connectivity, through social networking features included in the applications themselves, adds to these services a social dimesion, encompassing group dynamics and the use of data for market predictions. This paper describes how these three ways define how the user will receive the music that he/she listens, and therefore, make of these applications an example of interpassivity, which in turn contributes to a standardization of taste and of the horizon of possibilities for the user. Keywords: HEARING; COMMODITY; CRITICAL THEORY; STANDARDIZATION; INTERNET
Colección Alineamientos: Aproximaciones a la biocomputación desde el Arte
Authors: Puig Mestres Eloi 
Published: August 2016

Este artículo presenta un proyecto artístico que trata de mostrar algunos resultados de la experiencia desarrollada gracias a la colaboración del equipo de Genómica Computacional dirigido por D. Torrents del BSC-CNS de la Universidad Politécnica de Barcelona. La Colección Alineamientos consta de una serie cuadernos que comparan textos científicos y literarios. Se trata de una visualización en torno a la relación existente entre la código gramátical de un texto y la codificación genética a través de las cadenas de ADN. Un Alineamiento de secuencias en bioinformática es una forma de representar y comparar dos o más secuencias de ADN para resaltar zonas de semejanza que indican relaciones funcionales o evolutivas entre los genes. Nuestro objetivo fue modificar este método para poder comparar texto gramatical, caracteres que siguen un conjunto de reglas y principios que gobiernan el uso de una lengua determinada.Palabras-clave: METAMÉTODO; INVESTIGACIÓN ARTÍSTICA; ALINEAMIENTO DE SECUENCIAS; ARTE Y CIENCIA; PERFORMANCEAlignments collection: Biocomputation approaches from ArtAbstractThis paper aims to present an artistic project that show some experiences developed through collaboration Computational Genomics team led by David Torrents from BSC at the Polytechnic University of Barcelona. The Alignments Collection is a set a series notebooks comparing scientific and literary texts. This is a visualization of two artists from the University of Barcelona about the relationship between a grammatical text and DNA code. A Sequence Alignment in bioinformatics is a way to represent and compare two or more DNA sequences to highlight areas of similarity indicating functional or evolutionary relationships between genes. Our goal was to modify this method to compare, not DNA strands, but grammatical text, characters that follow rules and principles, which control the use of a particular language.Keywords: METAMETHOD; ARTISTIC RESEARCH; SEQUENCE ALIGNMENT; ART AND SCIENCE; PERFORMANCE
Design for digital repositories: Conceptualizing new communicative paradigms to filter and visualize scientific contents
Authors: Monteiro Bruno Miguel Azevedo , Tortosa Cuesta Rubén 
Published: August 2016

This article aims to conceptualize a new communicative paradigm applied to academic scientific repositories. The publication and the querying of articles, papers, journals, books and other documents, are an integral part of the research process. However, the querying and information visualization process in a scientific academic repository, often proves to be inefficient, because the wide range of results hardly fits in the user’s specific subject. In this sense, it is presented a brief analysis around major reference projects, which although based in the metric of article citations (impact factor), the primary goal lies in the visualization of an extensive citation structure and the relations established between the different scientific fields. Based on the modus operandi of these visualization interfaces, the main objective of this paper is to propose a new approach, where the filtering and the visualization of information is based in the user’s experience instead of the usual citation "object" centered approach.Keywords: COMMUNICATION DESIGN; FOLKSONOMIES; HIERARCHICAL AND RELATIONAL STRUCTURES; INFORMATION FLOOD; INFORMATION VISUALIZATION Design for digital repositories: Conceptualizing new communicative paradigms to filter and visualize scientific contentsResumenEste artículo propone un nuevo paradigma comunicativo aplicado a repositorios científicos académicos. La publicación de artículos y consulta como revistas, libros y otros documentos, son una parte integral del proceso de investigación. La búsqueda de la información en repositorios académicos, a menudo resulta ser ineficiente debido a la amplia gama de resultados obtenidos. En este sentido, se realiza un estudio breve en torno a los principales proyectos de referencia, que a pesar de estar basados en un análisis de citas de artículos fijados en el factor de impacto, presentan como característica principal la visualización de patrones entorno a una amplia estructura de citaciones y relaciones entre las distintas áreas. A partir del modus operandi de estas interfaces de visualización, el artículo plantea una nueva orientación fundada en la experiencia del usuario en lugar del habitual enfoque centrado en "objeto" de la citación.Palabras-clave: DILUVIO DE INFORMACIÓN; DISEÑO DE COMUNICACIÓN; ESTRUCTURAS JERÁRQUICAS E RELACIONALES; TAXONOMÍAS SOCIALES; VISUALIZACIÓN DE INFORMACIÓN
Examining of leisure time participation, psychological well-being and leisure negotiation of university students<p>Serbest zaman katılımı, psikolojik iyi olma ve serbest zaman engelleri ile baş etme stratejilerinin üniversite öğrencileri üzerinde incelenmesi
Authors: Karaca Ahmet Ali , Yerlisu Lapa Tennur 
Published: August 2016

The aim of this study is to determine whether psychological well-being statuses of university students according to their genders, their leisure negotiation strategies and their leisure exercise participation have been differentiated or not and detect the relationship between psychological well-being, leisure negotiation strategies and leisure activities participation of students. Sample of the study consisted of 400 female and 400 male making 800 students at total. As data collection tool in the study was used Leisure Time Exercise Questionnaire, Psychological well- being scales and Leisure Negotiation Scale. Mann-Whitney U test was used with the purpose of identifying difference, Pearson product–moment and Spearman’s rank correlation coefficient was used for correlation in the study. Consequently, psychological well-being of students shows positive linear relationship with both leisure negotiation strategies and leisure exercise participations. While psychological well-being statutes of students and leisure exercise participations show significant difference with respect their genders, leisure negotiation strategies do not. According to these results, while psychological well-being of females is higher, leisure exercise participations are lower with respect to males. ÖzetBu araştırmanın amacı; üniversite öğrencilerinin cinsiyetlerine göre psikolojik iyi olma durumlarının, serbest zaman engelleriyle baş etme stratejilerinin ve serbest zaman egzersiz katılımlarının farklılaşıp farklılaşmadığını tespit etmek ve öğrencilerin psikolojik iyi olma durumlarının, serbest zaman engelleriyle baş etme stratejileri ve serbest zaman egzersiz katılımları ile ilişkisini saptamaya yöneliktir. Araştırmanın örneklemini 400 kadın, 400 erkek toplam 800 öğrenci oluşturmaktadır. Araştırmada veri toplama aracı olarak; Serbest Zaman Egzersiz Anketi, Psikolojik İyi Olma Ölçekleri ve Serbest Zaman Engelleri ile Baş Etme Stratejileri Ölçeği kullanılmıştır. Araştırmada farklılığı tespit etmek amacıyla Mann-Whitney U testi, korelasyon için Pearson çarpım-moment ve Spearman'ın sıralama korelasyon katsayıları kullanılmıştır. Sonuç olarak; öğrencilerin psikolojik iyi olma durumları serbest zaman engelleriyle baş etme stratejileri ve serbest zaman egzersiz katılımlarıyla pozitif doğrusal yönde ilişki göstermektedir. Cinsiyetlerine göre psikolojik iyi olma durumları ve serbest zaman egzersizine katılımları anlamlı farklılık gösterirken, serbest zaman engelleriyle baş etme stratejileri farklılık göstermemektedir. Buna göre; kadınların psikolojik iyi olma durumları daha yüksek iken serbest zaman egzersiz katılımları erkeklere göre daha düşüktür.
Verteilte Ausgangsregelung von Multiagentensystemen mit gekoppelten Messgrößen
Authors: Wu Jingbo , Allgöwer Frank 
Published: August 2016

Zusammenfassung
In diesem Beitrag betrachten wir das Output Regulation-Problem für ein vernetztes System, bestehend aus autonomen
Agenten. Die Besonderheit liegt darin, dass Messgrößen gegebenenfalls von mehreren Agenten abhängen, aber trotzdem die
benötigten lokalen Zustandsgrößen auf verteilter Art und Weise geschätzt werden sollen, damit das Output
Regulation-Problem gelöst werden kann. Wir präsentieren einen ℋ∞-Beobachter- und Reglerentwurf, der die
benötigten Zustandsgrößen schätzt, dabei skalierbar ist, sprich auch für eine große Anzahl von Agenten geeignet ist, und
eine bestimmte Güte gegenüber Störgrößen sowohl für den Schätzfehler als auch für den Regelfehler garantiert.
Alzheimer’s disease: presence and role of microRNAs
Authors: Basavaraju Manasa , de Lencastre Alexandre 
Published: August 2016

AbstractAlzheimer’s disease (AD) is a progressive neurodegenerative disorder that accounts for the most cases of dementia. AD affects more than 25 million people globally and is predicted to affect nearly one in 85 people worldwide by 2050. AD is characterized by the accumulation of dense plaques of β-amyloid peptide (Aβ) and neurofibrillary tangles of hyperphosphorylated tau that cause impairment in memory, cognition, and daily activities. Although early-onset AD has been linked to several mutations, reliable genetic markers for late-onset AD are lacking. Further, the diagnosis of AD biomarkers has its limitations and cannot detect early-stage AD. The identification of accurate, early, and non-invasive biomarkers for AD is, therefore, an unmet challenge. Recently, microRNAs (miRNAs) have emerged as a novel class of gene regulatory elements with conserved roles in development and disease. Recent discoveries have uncovered roles of miRNAs in several model organisms during aging and have identified potential miRNAs biomarkers of AD. Here we will discuss this emerging field of miRNAs associated with AD and prospects for the future.
High-frequency operation of a pulsatile VAD – a simulation study
Authors: Rebholz Mathias , Amacher Raffael , Petrou Anastasios , Meboldt Mirko , Schmid Daners Marianne 
Published: August 2016

AbstractVentricular assist devices (VADs) are mechanical blood pumps that are clinically used to treat severe heart failure. Pulsatile VADs (pVADs) were initially used, but are today in most cases replaced by turbodynamic VADs (tVADs). The major concern with the pVADs is their size, which prohibits full pump body implantation for a majority of patients. A reduction of the necessary stroke volume can be achieved by increasing the stroke frequency, while maintaining the same level of support capability. This reduction in stroke volume in turn offers the possibility to reduce the pump’s overall dimensions. We simulated a human cardiovascular system (CVS) supported by a pVAD with three different stroke rates that were equal, two- or threefold the heart rate (HR). The pVAD was additionally synchronized to the HR for better control over the hemodynamics and the ventricular unloading. The simulation results with a HR of 90 bpm showed that a pVAD stroke volume can be reduced by 71%, while maintaining an aortic pulse pressure (PP) of 30 mm Hg, avoiding suction events, reducing the ventricular stroke work (SW) and allowing the aortic valve to open. A reduction by 67% offers the additional possibility to tune the interaction between the pVAD and the CVS. These findings allow a major reduction of the pVAD’s body size, while allowing the physician to tune the pVAD according to the patient’s needs.
Shear stress and von Mises stress distributions in the periphery of an embedded acetabular cup implant during impingement
Authors: Arndt Christoph , Görgner Alexandra , Klöhn Carsten , Scholz Roger , Voigt Christian 
Published: August 2016

Abstract
As literature implies, daily activities of total hip arthroplasty (THA) patients may include movements prone to implant-implant impingement. Thus, high shear stresses may be induced at the acetabular implant-bone interface, increasing the risk of implant loosening. The aim of the current study is to determine whether or not impingement events may pose an actual risk to acetabular periprosthetic bone. An existing experimental workflow was augmented to cover complete three-dimensional strain gage measurement. von Mises and shear stresses were calculated from 1620 measured strain values, collected around a hemispherical cup implant at 2.5 mm interface distance during worst-case impingement loading. A shear stress criterion for acetabular periprosthetic bone was derived from the literature. At the impingement site, magnitudes of von Mises stress amount to 0.57 MPa and tilting shear stress amount to -0.3 MPa at 2.5 mm interface distance. Conclusion can be drawn that worst-case impingement events are unlikely to pose a risk of bone material failure in the periphery around fully integrated cementless acetabular hip implants in otherwise healthy THA patients. As numerical predictions in the literature suggested, it can now be confirmed that impingement moments are unlikely to cause acetabular implant-bone interface fixation failures.