bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of SARS-CoV-2 pre-delta/delta and omicron variants on clinical outcomes in a systemic lupus erythematosus cohort from Puerto Rico
Authors: Serrano-Arroyo Lilliana , González-Meléndez Ariana , Ríos-Rivera Rafael , Rodríguez-González Valeria , Vilá Luis M. 
Published: February 2025

Objective To examine the clinical outcomes of systemic lupus erythematosus (SLE) patients with COVID-19 during the Pre-Delta/Delta and Omicron periods. Methods A retrospective study was conducted in a cohort of adult Puerto Ricans with SLE. Demographic parameters, SLE and COVID-19 manifestations, comorbidities, pharmacologic treatment, SLE exacerbations, hospitalizations, and mortality were determined. SARS CoV-2 infection was confirmed by polymerase chain reaction or antigen tests. Variables were compared between the Pre-delta/Delta and Omicron periods. Also, the proportion of COVID-19 cases and mortality of SLE patients was compared to the general population of Puerto Rico. Results Of the entire SLE cohort ( n = 347), 169 patients (48.7%) had COVID-19. Twenty-two patients had COVID-19 during the Pre-delta/Delta period and 147 during the Omicron period. The proportion of COVID-19 cases in the SLE cohort was significantly higher when compared to the adult general population of Puerto Rico (25.7%), but no difference in mortality was found. Overall, the clinical outcomes of COVID-19 in the SLE cohort were favorable, with low rates of lupus flares (3.0%), hospitalizations (3.6%), and mortality (0.6%). Patients with COVID-19 during the Pre-delta/Delta period were more likely to have oral ulcers, anti-Smith antibodies, and chronic kidney disease, whereas those during the Omicron period were more likely to have COVID-19 symptoms (rhinorrhea, sore throat, and cough). Conclusion In summary, is this group of Puerto Ricans with SLE, a high proportion had COVID-19, but disease exacerbation, hospitalization, and mortality rates were low. Few clinical differences were noted in SLE patients when comparing the Pre-delta/Delta and Omicron periods.
Factors affecting young women's participation in organized cervical cancer screening and non-organized testing – A population-based survey study
Authors: Lättilä Johannes , Siegfrids Filip , Heinävaara Sirpa , Sarkeala Tytti , Makkonen Petra , Leivonen Aku , Partanen Veli-Matti , Vahteristo Maija 
Published: February 2025

Objectives Organized cervical cancer screening reduces cervical cancer incidence and mortality and is widely implemented across Europe. However, non-organized cervical cancer testing remains common. Frequent testing may lead to overdiagnosis and unnecessary treatment, especially among young women. This study aims to identify factors influencing young women's participation in organized cervical cancer screening and non-organized cervical cancer testing. Methods We surveyed 1411 women aged 15–35 living in Finland, assessing their knowledge and attitudes toward cervical cancer testing. Survey responses were linked to sociodemographic registry data and cervical cancer testing records. Descriptive statistics of survey responses and logistic regression were used to identify factors influencing participation in both organized screening and non-organized testing. Results Human papillomavirus vaccination status, medical contraception use, and gynecologist visit frequency were key predictors of non-organized testing. Human papillomavirus-vaccinated women were 50% less likely to undergo non-organized testing compared to those unvaccinated. Medical contraception users were 5.3 times more likely compared to non-users, and frequent gynecologist visitors were 1.5 times more likely to undergo non-organized testing compared to infrequent visitors. For organized screening, women with tertiary education were 4.1 times more likely to participate than those with primary education. Women appreciated the flexibility in screening times and locations. Human papillomavirus awareness was high with 91.3% of respondents having heard of the virus. Conclusions To address non-organized testing among young women, comprehensive education about human papillomavirus and cervical cancer screening is essential, both for screened women and healthcare professionals. Aligning screening practices with women's preferences may improve adherence to organized screening, ultimately benefiting public health outcomes.
Chinese Stock Market Performance and Natural Disasters
Authors: Boungou Whelsy , Djatche Melchisedek Ngambou , Biekpe Nicholas 
Published: February 2025

In this article, we investigate the impact of natural disasters on Chinese stock market performance over the period from 2017 to 2023. Using monthly financial data from 2,117 Chinese companies and climate data relating to floods and storms, our results highlight a negative association between stock market returns and natural disasters. We observe that the recurrence of natural disasters reduces the stock market returns of Chinese companies. We also find that, whatever the intensity of the natural disaster (number of deaths and people affected) and the company’s sector of activity, the observed effect is verified. Our results also show that firms’ Environmental, Social, and Governance (ESG) performance influences their exposure to natural disasters. We find that firms with higher ESG scores perform better despite natural disasters than other firms. This article thus provides the first detailed evidence of Chinese firms’ exposure to natural disasters. JEL Codes: G12, G32, Q40
The influence of perceived high-performance work systems on innovative work behavior: Mediating role of work engagement
Authors: Hassanah Husin Noor , Abu Mansor Nur Naha , Javaid Muhammad Umair , Widarman Beni 
Published: February 2025

Background The principle of HRM requires employees to come up with novelty and creative ideas in work organizations. Prior research viewed high-performance work systems (HPWS) as an essential factor that promotes innovation and performance outcomes as it encourages employee creativity, risk-taking, and experimentation. Objective The current study investigated the influence of HPWS on innovative work behavior in medium-sized manufacturing enterprises through work engagement. Although much has been done to analyze various outcomes of high-performance work systems in large-scale manufacturing industries, little is known about its implementation amongst medium-sized manufacturing enterprises in Malaysia. Methods This study employed a group of 170 middle-management employees from medium-sized manufacturing businesses in Klang Valley, Malaysia. To perform the analysis, the researchers used SmartPLS 3.0 software. The list of medium-sized enterprises in the Klang Valley area was obtained from SME Corporation Malaysia. G*Power version 3.1.9.2 statistical program was used to perform power analysis in determining the minimum sample size for this study. The theory of job demands-resources (JD-R) model underpins the linkages between HPWS and IWB of employees in medium-sized manufacturing enterprises. Results The outcome indicated a noteworthy relationship between innovative work behavior and selective staffing, mentoring, and employee participation. Additionally, the study demonstrated that work engagement is crucial in promoting innovative work behavior with a medium effect size. Moreover, the connection between selective staffing, mentoring, and employee participation is mediated by work engagement. Conclusions This research expands the existing information on ways to implement HPWS in medium-sized manufacturing companies. Moreover, it offers practical guidance to decision-makers, especially in promoting innovation among staff through effective high-performance work practices.
Development of a Core Outcome Set for the Audit of Cleft Care in Malaysia
Authors: Shahrul Al Imran , Nik Mustapha Nik Mukhriz , Ahmad Mas Suryalis , Kharbanda O. P. , Abd Rahman Aida Nur Ashikin 
Published: February 2025

Objective To develop a core outcome set for the audit of cleft care in Malaysia. Design To generate a core outcome set for patients dealing with cleft lip and/or palate within Malaysia, a combination of scholarly research reviews and consensus-driven methodologies, such as questionnaires and collaborative discussions, were utilized to guide the development process. Setting Multicenter study. Feedback obtains via face-to-face and online interaction. Participants Cleft Clinicians, Cleft Lip and Palate Association of Malaysia members, hospitals, and government bodies personal. Main Outcome Measure Participants provide their feedback and suggestions of each outcome measure. Results Through a deliberative process, agreement was established on a uniform set of outcome measures selected from an initial list of 108 potential outcomes. These agreed-upon measures were classified into 12 primary domains: demographic, cleft detail, pregnancy, general pediatric, otolaryngology/audiology, speech, surgical, orthodontics, pediatric dentistry, radiology, photographs, and study models. Conclusion A specialized core outcome set has been successfully developed for patients with cleft lip and/or palate, aiming to facilitate its implementation within the Malaysian healthcare system.
Irinotecan-induced dysarthria and management
Authors: Marjoncu Dennis , Jones Kerri 
Published: February 2025

Background Irinotecan is chemotherapeutic agent often used in abdominal cancers such as colorectal and pancreatic cancers. While often associated with non-central nervous system (CNS) adverse effects, in rare cases it may present with paresthesias and dysarthrias. In one case, a patient received an irinotecan-containing regimen (fluorouracil, irinotecan, oxaliplatin) and experienced several neurotoxic effects, which was successfully managed. Case Report A female patient with newly-diagnosed pancreatic cancer was started on fluorouracil, irinotecan, and oxaliplatin (modified FOLFIRINOX). She developed dysarthrias early on in the course. Causality assessment was conducted via the Naranjo criteria, yielding a score of 6, indicating a probable adverse reaction. Management & Outcome Initially managed with steroids and lorazepam, she was eventually given a prophylactic strategy of atropine 0.4 mg and a longer infusion time of 3 h instead of 90 min with as needed lorazepam. This strategy alleviated the dysarthrias and the patient was able to complete 12 cycles of therapy, resulting in a partial response at the end of treatment. Discussion Prolonging the infusion and giving prophylactic atropine may help to prevent these rare adverse effects of irinotecan.
Balloon occlusion testing for non-sinus-stenosis venous pulsatile tinnitus: A technical case series
Authors: Brake Aaron Daniel , Lingam Sivani , Galate Vince , Turner Robert , Abraham Michael G 
Published: February 2025

Introduction Pulsatile tinnitus (PT) affects ∼ 10% of the population and can be debilitating. Venous etiologies of PT are increasingly recognized. Identifying the symptomatic vessel, particularly with multiple venous anomalies, remains challenging. Methods In this case series, we utilized venous balloon occlusion testing (vBOT) as a real-time diagnostic tool to identify symptomatic vessels in non-sinus stenosis venous PT. vBOT involved using a transform balloon (7 mm × 7 mm) under fluoroscopic guidance to occlude the venous anomaly, with immediate assessment of symptom resolution. Results We report four cases involving high-riding jugular bulbs, jugular bulb diverticula, and enlarged emissary veins. vBOT successfully identified the culprit vessels, guiding targeted endovascular coil embolization. These procedures led to significant symptom resolution in all cases, though the varied patient responses underscored the importance of a tailored, iterative approach, particularly in those with bilateral symptoms or multiple venous variants. Conclusion This series illustrates the utility of vBOT in accurately identifying symptomatic vessels in non-sinus stenosis venous PT, enabling effective, targeted interventions. While vBOT is a valuable diagnostic tool, its limitations, including potential false negatives due to PT variability or ambient noise, must be considered. Incorporating vBOT into the diagnostic framework for PT can enhance precision in vessel selection and improve patient outcomes, particularly in cases with uncommon venous etiologies.
Effects of physical rehabilitation interventions on exercise performance, dyspnea, and health-related quality of life in acute and post-acute COVID-19 patients: Systematic review and meta-analysis
Authors: Neto Mansueto Gomes , Suzart Coutinho de Araujo William , Pinto Ana Carolina Pereira Nunes , Saquetto Micheli Bernardone , Martinez Bruno Prata , Gomes Vinicius Afonso , Brites Carlos , Carvalho Vitor Oliveira 
Published: February 2025

Objective To analyze the published randomized controlled trials (RCTs) that investigated the effects of physical rehabilitation interventions provided directly (face to face) and by telerehabilitation on exercise performance, dyspnea, and health-related quality of life (HRQoL) in acute and post-acute COVID-19 patients. Methods For this systematic review and meta-analysis, different electronic databases were searched up to January 2023. Mean difference (MD), (standardized mean difference (SMD) were calculated. Results 34 studies (2214 patients) met the study criteria. Physical interventions may improve aerobic capacity in acute COVID-19 (SMD 1.7; 95% CI 0.37, 2.8) and in post-acute COVID-19 participants (MD 0.4; 95% CI 0.1, 07) compared to usual care for acute and pos-acute COVID-19 patients, respectively. Physical interventions may also improve dyspnea in acute (SMD −1.4; 95% CI −0.8, −0.01) and in post-acute COVID-19 participants (MD −0.4; 95% CI −0.7, −0.2) compared to usual care. Physical interventions may result in an improvement in HRQoL (physical domain) (SMD 0.6; 95% CI 0.3) in post-acute COVID-19 participants compared to usual care in pos-acute COVID-19 patients. Discussion The results support that physical rehabilitation interventions improve aerobic capacity and dyspnea in acute and post-COVID-19 patients. Moreover, physical interventions improve physical domain in HRQoL
Privacy and preserving data processing and dissemination framework for internet of vehicle
Authors: Almansour Shahad 
Published: February 2025

In Intelligent Transportation Systems (ITS), ubiquitous connectivity and automation are essential components of the Internet of Vehicles (IoV). The real-time information provided by a data-driven ITS is based on extensive vehicular data. Cyberattacks and privacy breaches are inherent risks of the IoV, raising significant concerns about data security. As a solution, we propose a privacy-preserving and data dissemination model for managing vast amounts of data generated within the IoV. The model adapts to user-specific needs and is influenced by interactions with neighbours and service providers. ITS applications are studied to mitigate potential privacy risks by analyzing their requirements. A data-balancing approach is used to prevent privacy leaks among vehicular services by using data from different time intervals to validate operational parameters. Individual privacy is protected, and IoV infrastructure security and reliability are strengthened, both of which benefit neighbouring vehicles and the broader transportation network. “Integrating blockchain and deep learning provides a powerful approach to intrusion detection in Industrial IoT (IIoT) environments, combining blockchain's security and transparency with deep learning's precision in detecting threats while minimizing false positives. In Intelligent Transportation Systems (ITS), core elements of the Internet of Vehicles (IoV) rely on extensive vehicular data for real-time operations but face significant risks from cyberattacks and privacy breaches. To address these challenges, we propose a privacy-preserving data dissemination model tailored to user needs and influenced by interactions with neighbors and service providers. A data-balancing approach prevents privacy leaks by validating operational parameters using data from varying intervals. This model strengthens IoV security, safeguards individual privacy, and enhances the reliability of the transportation network.”
Asymptomatic Preaxial Polydactyly of Bifid Hallux Without a Supernumerary Digit Presenting With Earlobe Malformations: A Rare Case Report
Authors: Perkins Chanel Houston 
Published: February 2025

Syndactyly-polydactyly-ear lobe (SPEL) syndrome is a rare, genetic, congenital limb malformation syndrome that can be characterized by 6 different human phenotypes. We report a rare case of SPEL syndrome in a young woman with right earlobe malformations and asymptomatic preaxial polydactyly with partial duplication of the right hallucal distal phalanx without a supernumerary toe. Unique aspects of our patient’s clinical presentation include lack of a supernumerary digit with a bifurcated distal phalanx, associated earlobe malformations, adult age, and no reported familial history of SPEL syndrome. Syndactyly-polydactyly-ear lobe syndrome has not been reported in the literature since 1976, making the present case particularly noteworthy. Level of Evidence: Level 5, Case Report
Endovascular treatment of intracranial aneurysms with silk vista baby flow diverter: A systematic review and meta-analysis
Authors: Hajikarimloo Bardia , Mohammadzadeh Ibrahim , Tos Salem M. , Hashemi Rana , Habibi Mohammad Amin , Hasanzade Arman , Bana Sara , Hooshmand Mahdi , Ghorbanpouryami Fatemeh , Najari Dorsa , Hezaveh Ehsan Bahrami 
Published: February 2025

Background The Silk Vista Baby (SVB) flow diverter (FD) is a stent designed for small vessels ranging from 1.5 to 3.5 mm. It is the only FD deliverable through a 0.017-inch microcatheter. This systematic review and meta-analysis aimed to assess the SVB utilization in intracranial aneurysms (IAs). Methods Four electronic databases, PubMed, Scopus, Embase, and Web of Science, were searched from inception to November 5th, 2024. Results Ten studies with 359 patients with 373 IAs were included. Our results revealed a pooled complete occlusion rate of 65% (95%CI: 43%–83%), a favorable outcome rate of 94% (95%CI: 83%–100%), and a morbidity rate of 4% (95%CI: 0%–11%). Our meta-analysis revealed a pooled in-stent thrombosis rate of 2% (95%CI: 1%–5%), side branch occlusion rate of 2% (95%CI: 0%–3%), intracerebral hemorrhage (ICH) rate of 2% (95%CI: 1%–4%), and device shortening rate of 4% (95%CI: 3%–6%). The subgroup analysis showed that the complete occlusion rate (≤6: 84% [95%CI: 49%–100%] vs >6: 58% [95%CI: 41%–73%], p < .001) was higher in studies with 6-month or lower follow-up duration, and the favorable outcome rate was higher in those with greater than 6-month duration (≤6: 84% [95%CI: 73%–93%] vs >6: 97% [95%CI: 82%–100%], p < .001). Conclusion SVB is an efficient and safe therapeutic option for managing IAs. We demonstrated that it is associated with promising clinical and radiological outcomes and low rates of complications.
Evaluating YouTube as a source of information on amyotrophic lateral sclerosis
Authors: Untalan Liamuel Giancarlo V , Malanog John Paulo D , Jamora Roland Dominic G 
Published: February 2025

Background Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease that leads to progressive motor weakness and eventual death. Recent years have seen an increase in online information on ALS, with the popular video platform YouTube becoming a prominent source. We aimed to evaluate the quality, reliability, actionability, and understandability of ALS videos on YouTube. Methods A search was performed using the keyword “Amyotrophic Lateral Sclerosis” on YouTube. A total of 240 videos were viewed and assessed by two independent raters. Video characteristics such as type of uploader, views, likes, comments, and Video Power Index were also collected. Results Videos had moderate to low quality and reliability (Global Quality Scale [GQS] and modified DISCERN [mDISCERN] median 2.5), and poor understandability and actionability (PEMAT total median 8.5). Among the general video characteristics, only length of video showed a significant positive correlation across the tools (with mDISCERN [ p < 0.001]; with GQS [ p < 0.001]; with PEMAT [ p < 0.001]). Videos from physicians ( p = 0.024, sig <0.05), other healthcare professionals ( p = 0.017, sig <0.05), and educational channels ( p = 0.001, sig <0.05) had better quality when compared to others. Conclusion YouTube videos are a poor source of information for ALS as videos tend to have moderate to low quality and reliability and are poorly understandable and actionable. Longer videos, and videos uploaded by those in the healthcare and educational fields, were found to perform relatively better. Thus, when using YouTube, caution and careful attention to the video characteristics are recommended.
The Association Between Adjacent Forces and the Development of Proximal Junctional Kyphosis: A Musculoskeletal Analysis
Authors: Alavi Fatemeh , Nielsen Christopher J. , Lewis Stephen , Rampersaud Raja , Cheung Angela M. 
Published: February 2025

Study Design Biomechanical modeling study. Objectives Despite several recognized risk factors for proximal junctional kyphosis (PJK), its causative mechanism remains unknown. There are limited biomechanical studies to elucidate the association of sagittal alignment with PJK. Our aim is to determine the association of adjacent forces with PJK development. Methods ASD patients operated on with posterior fusion from T9-T11 to the pelvis and had 2 year follow-up were included in this retrospective study. Patient-specific musculoskeletal models were created from EOS images. High vs low normalized vertebral forces were defined based on a threshold of 0.2 for shear and 0.5 for compression. The load ratio was defined as the ratio of immediate postoperative to preoperative vertebral forces. Results A total of 35 patients (19 PJK, 16 Non-PJK) were included. PJK patients had statistically significant global malalignment with respect to global tilt (GT), T1 pelvic angle (TPA) and C2-UIV+1PA. A high-risk zone for the development of PJK is defined as high normalized shear and/or compression with a high load ratio. While none of the non-PJK patients were in the high-risk zone, 5 PJK patients were not in that zone, suggesting factors other than alignment may have contributed to this adverse event. Despite low shear for 3 of these non-PJK patients, they experienced high shear ratio. Conclusions The proposed thresholds were accurate in 86% of patients who developed PJK. These findings suggest postoperative shear at UIV+1 as an important risk factor for PJK. Keeping shear force low in alignment will help surgeons reduce PJK development.