bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive Genomic Profiling Aids in Distinguishing Metastatic Recurrence from Second Primary Cancers
Authors: Weinberg Benjamin A. , Gowen Kyle , Lee Thomas K. , Ou Sai-Hong Ignatius , Bristow Robert , Krill Lauren , Almira-Suarez M. Isabel , Ali Siraj M. , Miller Vincent A. , Liu Stephen V. , Klempner Samuel J. 
Published: February 2017

Abstract

Background
Metastatic recurrence after treatment for locoregional cancer is a major cause of morbidity and cancer-specific mortality. Distinguishing metastatic recurrence from the development of a second primary cancer has important prognostic and therapeutic value and represents a difficult clinical scenario. Advances beyond histopathological comparison are needed. We sought to interrogate the ability of comprehensive genomic profiling (CGP) to aid in distinguishing between these clinical scenarios.

Materials and Methods
We identified three prospective cases of recurrent tumors in patients previously treated for localized cancers in which histologic analyses suggested subsequent development of a distinct second primary. Paired samples from the original primary and recurrent tumor were subjected to hybrid capture next-generation sequencing-based CGP to identify base pair substitutions, insertions, deletions, copy number alterations (CNA), and chromosomal rearrangements. Genomic profiles between paired samples were compared using previously established statistical clonality assessment software to gauge relatedness beyond global CGP similarities.

Results
A high degree of similarity was observed among genomic profiles from morphologically distinct primary and recurrent tumors. Genomic information suggested reclassification as recurrent metastatic disease, and patients received therapy for metastatic disease based on the molecular determination.

Conclusions
Our cases demonstrate an important adjunct role for CGP technologies in separating metastatic recurrence from development of a second primary cancer. Larger series are needed to confirm our observations, but comparative CGP may be considered in patients for whom distinguishing metastatic recurrence from a second primary would alter the therapeutic approach.
ICT DALAM PERPUSTAKAAN
Authors: Riyana Cepi 
Published: February 2017

AbstrakPerpustakaan dan pusat informasi mengalami pergeseran paradigma dalam sumber-sumber informasinya, layanannya, dan pada orientasi penggunanya, serta tanggungjawab staff/pekerja dalam layanan dan sistem di dalamnya. Pergeseran paradigma informasi yang berakibat pada perubahan pola kerja dan orientasi institusi yang bergerak dalam bidang ilmu pengetahuan seperti perpustakaan, Kemajuan teknologi informasi yang memudahkan perpustakaan untuk melakukan sharing informasi melalui pemanfaatan ICT, sehingga melahirkan virtual library. Knowledge management dapat digunakan untuk meningkatkan kinerja perpustakaan. Knowledge management dapat dijadikan sebagai pemicu agar pustakawan lebih inovatif dan kreatif mengembangkan konsep perpustakaan. Digital Library menggambarkan perpustakaan digital sebagai lingkungan yang bersama-sama memberi koleksi, pelayanan, dan manusia untuk menunjang kreasi, diseminasi, penggunaan, dan pelestarian data, informasi, dan pengetahuan. ICT telah memberikan kontribusi terhadap lahirnya berbagai aplikasi dalam perpustakaan, sehingga memunculkan konsep digital library dan otomasi perpustakaan yang berbasis pada data dan proses digitalisasi. Kata Kunci: Information and Communication Technology, Digital Library
ANALISIS SISTEM INFORMASI PERPUSTAKAAN IAIN SURAKARTA DENGAN PIECES
Authors: Maslahah Khoirul 
Published: February 2017

AbstrakPerkembangan teknologi informasi pada saat ini mencakup hampir semua bidang dalam kehidupan manusia. Seperti halnya dalam bidang perpustakaan perkembangan teknologi informasi telah merambah dunia ini. Peranan teknologi informasi dalam bidang perpustakaan mengakibatkan adanya komputerisasi dalam segala kegiatan perpustakaan. Perkembangan teknologi ini memberi efek yang postif untuk dunia perpustakaan, salah satunya adalah dibangunnya suatu sistem informasi yang dapat diakses oleh siapa saja dan dimana saja. Kata Kunci: Sistem Informasi Perpustakaan, PIECES (Performance, Information, Economy, control, Eficiency, dan Service)
IMPLEMENTASI PELAKSANAAN MANAJEMEN MUTU ISO 9001 : 2008 DI PERPUSTAKAAN UPI BANDUNG IMPLEMENTASI PELAKSANAAN MANAJEMEN MUTU ISO 9001 : 2008 DI PERPUSTAKAAN UPI BANDUNG
Authors: Bahtiar Herli 
Published: February 2017

Abstrak Penelitian ini bertujuan untuk mengkaji sejauh mana penerapan dari Implementasi SMM ISO 9001:2008 di Perpustakaan Universitas Pendidikan Indonesia (UPI) Bandung. inti permasalahan dari penelitian ini adalah bagaimana proses dari perencanaan, pengorganisasian, pelaksanaan dan pengawasan Implementasi ISO 9001 : 2008 yang diterapkan di perpustakaan Universitas Pendidikan Indonesia, Penelitian ini menggunakan metode deskriptif dengan analisis kualitatif, teknik pengumpulan data menggunakan metode pengamatan lapangan (Observasi), wawancara dan studi kepustakaan /literatur-literatur.berdasarkan dari hasil penelitian ini diperoleh gambaran mengenai bagaimana proses Imoplementasi ISO 9001 :2008 diterapkan pada perpustakaan Universitas Pendidikan Indonesia dari mulai perencanaan, pengorganisasian, pelaksanaan dan pengawasannya. Kata Kunci: Penerapan ISO 9001:2008; Manajemen Mutu; PerpustakaanAbstract This research aimed to study how far the implementation of SMM ISO 9001:2008 has gone in the library of Indonesia State University (UPI) Bandung. The problem of this research is how the process of planning, organizing, implementing and controlling of ISO 9001:2008 Implementation is conducted in the library of Indonesia State University. This research used descriptive method with qualitative analysis and the data collected by using field observation method, interview and library study. The result of this research gives description on how the process of ISO 9001:2008 Implementation was conducted in the library of Indonesia State University, starting from planning to organizing, implementing and controlling. Keywords: ISO 9001:2008 implementation, quality management, library
HUBUNGAN MANAJEMEN KEPALA SEKOLAH DENGAN PENYELENGGARAAN PERPUSTAKAAN SEKOLAH
Authors: Nurlisma Lisna , Komarudin Yooke Tjuparmah 
Published: February 2017

Abstrak. Masalah yang menjadi kajian dalam penelitian ini adalah penyelenggaraan perpustakaan sekolah. Inti kajiannya difokuskan pada salah satu faktor yang mempengaruhi penyelenggaraan perpustakaan sekolah yaitu manajemen kepala sekolah. Berdasarkan hal tersebut, pokok masalah diungkap dalam penelitian ini adalah bagaimana hubungan manajemen kepala sekolah dengan penyelenggaraan perpustakaan sekolah. Penelitian ini terdiri dari dua variabel yaitu manajemen kepala sekolah dan penyelenggaraan perpustakaan sekolah. Manajemen kepala sekolah diukur melalui indikator leading, planning, organizing dan controlling. Penyelenggaraan perpustakaan sekolah diukur melalui indikator layanan, koleksi dan anggaran. Populasi dalam penelitian ini adalah siswa SMAN 10 Bandung, dengan sampel 95 orang yang dihitung berdasarkan rumus Yamane dengan metode simple random sampling. Metode penelitian menggunakan metode deskriptif dengan pendekatan kuantitatif. Teknik pengumpulan data menggunakan angket tertutup dengan skala lima kategori Likert dengan analisis regresi dan korelasi, serta wawancara terstruktur untuk melengkapi data dari angket. Berdasarkan hasil analisis data diketahui manajemen kepala sekolah berpengaruh cukup kuat terhadap penyelenggaraan perpustakaan sekolah. Secara garis besar manajemen kepala sekolah SMAN 10 Bandung termasuk dalam kategori baik. Hasil pengujian manajemen kepala sekolah terhadap penyelenggaraan perpustakaan sekolah menunjukkan indikator leading dan organizing berada pada kategori sedang, sementara indikator planning dan controlling berada pada kategori kuat.
LITERASI INFORMASI MEDIA: Studi Kasus Manfaat Media Massa Terhadap Difusi Inovasi Pertanian di Kecamatan Singaparna Kabupaten Tasikmalaya
Authors: Hafiar Hanny , Puspitasari Lilis , Anwar Rully Khairul 
Published: February 2017

AbstractConseling is an advanced activity of information dispersion aims to change the society’s attitude and behavior so as to accept and apply new ideas that have been presented. Changes in attitudes and behaviors of farmers in adopting innovation delivered is expected to improve the farmers’ ability so that the quality and quantity of production increase, which in turn help to improve their living standards. In addition, an innovation can be accepted by the society through several stages: awareness, interest, evaluation, trial, and adoption.Keywords: mass media, innovation diffusion, counselingAbstrakPenyuluhan merupakan kegiatan lanjutan dari penyebaran informasi bertujuan untuk mengubah sikap dan perilaku masyarakat agar menerima dan menerapkan ide-ide baru yang telah disajikan. Perubahan sikap dan perilaku petani dalam mengadopsi inovasi yang disampaikan diharapkan dapat meningkatkan kemampuan petani sehingga kualitas dan kuantitas peningkatan produksi, yang pada gilirannya membantu untuk meningkatkan standar hidup mereka. Selain itu, inovasi dapat diterima oleh masyarakat melalui beberapa tahap: kesadaran, minat, evaluasi, percobaan, dan adopsi.Kata kunci: media massa, difusi inovasi, konseling
PERAN PERPUSTAKAAN DAN TENAGA PERPUSTAKAAN SEKOLAH/MADRASAH DALAM MENINGKATKAN MUTU PENDIDIKAN DI SEKOLAH/MADRASAH
Authors: Dewi Laksmi , Suhardini Asep Dudi 
Published: February 2017

AbstractThis paper begins with the emergence of problems in the implementation of education about the role of the school/madrasah library. Library as one of the important factor in improving the quality of the learning process in schools / madrasah. It is undeniable that the number of libraries and school/madrasah librarian are still below the average of national standard of library school/ madrasah. Required the intervention in enhancing the role of libraries and school library personnel / madrasah. Through training madrassa library management, training participants are expected to increase their ability after the training, particularly in carrying out his duties as a school library personnel. Based on the results of pre-test and post-test data showed that it had an increased knowledge of the trainees. The trainees also found the library management training has particular relevance and effectiveness in improving the understanding related to the management of the library. After training, the trainees also apply in libraries madrassas through improvements in the management of the library. Training library management has proven effective in improving knowledge, attitudes, and skills in carrying out the task of managing the library.Keyword: Library, school librarian, School quality improvement AbstrakTulisan ini diawali dengan munculnya permasalahan dalam pelaksanaan pendidikan tentang peran perpustakaan sekolah/madrasah. Perpustakaan sebagai salah satu factor penting dalam meningkatkan kualitas proses pembelajaran di sekolah/madrasah. Tak dapat dipungkiri bahwa jumlah perpustakaan dan tenaga perpustakaan sekolah/madrasah masih berada di bawah rata-rata standar perpustakaan sekolah/madrasah yang telah ditetapkan oleh pemerintah. Diperlukan adanya intervensi dalam meningkatkan peran perpustakaan dan tenaga perpustakaan sekolah/ madrasah. Melalui pelatihan pengelolaan perpustakaan madrasah, peserta pelatihan diharapkan dapat meningkat kemampuannya setelah mengikuti pelatihan tersebut, khususnya dalam melaksanakan tugasnya sebagai tenaga perpustakaan sekolah. Berdasarkan hasil pre test dan post test diperoleh data bahwa secara pengetahuan peserta pelatihan memiliki peningkatan. Peserta pelatihan juga berpendapat bahwa pelatihan pengelolaan perpustakaan memiliki relevansi dan efektivitas khususnya dalam meningkatkan pemahamannya terkait pengelolaan perpustakaan. Setelah mengikuti pelatihan, peserta pelatihan pun menerapkannya di pepustakaan madrasahnya melalui pembenahan dalam pengelolaan perpustakaan. Pelatihan pengelolaan perpustakaan terbukti efektif memberikan peningkatan pengetahuan, sikap, dan keterampilannya dalam melaksanakan tugas mengelola perpustakaan.Keyword: Perpustakaan, Tenaga Perpustakaan, Kualitas Pendidikan Madrasah
OPTIMALISASI PENDIDIKAN PEMUSTAKA DALAM PEMANFAATAN LAYANAN PERPUSTAKAAN OLEH MAHASISWA PADA PERPUSTAKAAN UNIVERSITAS NEGERI PADANG
Authors: - Marlini 
Published: February 2017

Abstrak. Penelitian ini bertujuan untuk mengetahui dampak dari pendidikan pemustaka terhadap layanan perpustakaan dan upaya yang dilakukan oleh pustakawan untuk pengguna perpustakaan seperti para mahasiswa yang menggunakan layanan perpustakaan di Perpustakaan Universitas Negeri Padang. Metode yang digunakan dalam penelitian ini adalah deskriptif kuantitatif dengan variabel-variabel yang terdiri dari penggunaan layanan perpustakaan, apresiasi mahasiswa terhadap pendidikan pemustaka, dan pengaruh kunjungan terhadap pemanfaatan fasilitas perpustakaan. Populasi penelitian terdiri dari semua mahasiswa angkatan tahun 2012 dan telah menyelesaikan kegiatan pendidikan pemustaka. Sampel yang digunakan adalah sampel aksidental (accidental sampling) dengan asumsi bahwa sampel terdiri dari siapa saja yang secara kebetulan bertemu dengan peneliti di perpustakaan. Jika mahasiswa yang bertemu cocok dengan kriteria sampel maka digunakan sebagai sampel untuk sumber data. Teknik pengumpulan data yang digunakan adalah observasi, angket, wawancara, dan studi literature. Hasil penelitian menunjukkan bahwa pengetahuan dan penggunaan layanan perpustakaan, apresiasi mahasiswa terhadap pendidikan pemustaka dan pengaruh kunjungan terhadap pemanfaatan fasilitas perpustakaan berada dalam kategori baik dan sudah optimal.Kata kunci : User Education, Pelayanan Perpustakaan, Pengunjung Abstract. This study aims to determine the impact of user education on the use of library services and the efforts made by librarian to users such as students to use library services at Padang State University Library. The method used was a quantitative descriptive study, with of variables consisting of students' knowledge about the use of library services, students' appreciation for user education, and the influence of visits on the library facility utilization. The population in this study is the Padang State University students who entered college in 2012 and have completed the educational activities of the user education. The sample used is accidental sampling with the assumption that the accidental sampling is sampling technique by coincidence, that anyone who, by chance, met with researcher can be used as a sample, if the person is found to match the time of determining the required sample as data source. Data collection techniques used were observation, questionnaires, interviews, and literature. The data collected was presented in the form of tables that are easy to be read and interpreted. The results show that students' knowledge about the use of library services, students' appreciation for user education, and the influence of visits on the library facility utilization are all in the good category and have been optimized.Keywords: User Education, Library Services, Visits.
Neonatal mortality of sick newborns admitted in a tertiary care teaching hospital in Tamil Nadu, South India
Authors: Jeganathan Sathya , S. A. Rsavikmar , A. Tamilmani , P. Parameshwari P. , Chinnarajalu Asvatha Valarmathi , Kolkar Yalaguraswami B. 
Published: February 2017

Background: Neonatal period is an important period in the life where most of the deaths are preventable. In India every year 1 million babies die, which contributes to 25% of the world neonatal mortality. Perinatal death is very high in developing countries including India.Methods: A record based retrospective study was conducted in the Neonatal Intensive care unit(NICU) of Department of Pediatrics, Chengalpattu Medical College in Tamil Nadu, South India. The records were collected for the period of one year from January 2016 to December 2016. All the neonates admitted in the NICU during this period were included in the study. Results: The number of total deliveries in Chengalpattu Medical College for the year 2016 was 9339. Total number of live births was 9170 of which 21.88% were low birth weight and 15.96% were preterm delivery. Mortality rate in males is 3.2% (54/1689) and mortality rate in female is 3.98% (55/1383). The difference in mortality rate among male and female neonates was not significant. Respiratory distress syndrome and prematurity related illness contributed to 45% of the total neonatal deaths (39/110). Birth asphyxia and meconium aspiration contributed to 23.6 % (24/110). Rest of the mortality was contributed by ELBW 11.8% (13/110), major congenital malformation 6.4% (7/110), sepsis 1.8% (2/110) and others.Conclusions: Prematurity related problems and respiratory distress are the leading causes of neonatal mortality and morbidity followed by birth asphyxia in CMCH. Proper identification and management of pre-eclampsia, prevention of preterm and low birth weight deliveries are the need of the hour to reduce the mortality and morbidity among neonates.
Failure of Patellar Plating with Mini-Fragment Implants
Authors: Miles Daniel T. , Graves Matthew L. , Spitler Clay A. , Bergin Patrick F. 
Published: February 2017

Case:
A 40-year-old woman presented to the emergency department with a comminuted fracture of the patella with separation of the bone fragments. The patient underwent an open reduction and osteosynthesis using medial and lateral 2.0-mm nonlocking plates, which subsequently led to pain in the anterior and posterior aspects of the knee.

Conclusion:
In this patient, bicolumnar nonlocking plating was unable to adequately resist the tensile forces of the extensor mechanism. We believe that the probable cause of failure was an insufficient neutralization of the tensile forces exerted by the extensor mechanism. Because of the substantial forces acting on the patella, a method of converting these tensile forces into compressive forces is very beneficial, as seen with anterior tension-band wiring. Although we used nonlocking plates in our patient, we believe that locking-plate fixation placed along the medial and lateral columns also would have had a biomechanical disadvantage in dispersing the tensile forces exerted by the extensor mechanism.
Bilateral Simultaneous Femoral Neck Stress Fracture Despite Clinical Recovery from Anorexia Nervosa
Authors: Hernigou Jacques , Koulischer Simon , Maes Renaud 
Published: February 2017

Case:
A 38-year-old woman who had returned to sports activity (running) after having clinically recovered from anorexia nervosa presented with a bilateral femoral neck stress fracture that was treated with bilateral hip osteosynthesis.

Conclusion:
Although exercise is usually considered to be beneficial for health, heavy exercise (such as running) after recovery from anorexia nervosa may be associated with an increased risk of fracture.
Reconstruction of Extended Bone Defects Using Massive Allografts Combined with Surgical Angiogenesis
Authors: Struckmann Victoria , Schmidmaier Gerhard , Ferbert Thomas , Kneser Ulrich , Kremer Thomas 
Published: February 2017

Case:
A 20-year-old patient presented with an extended composite knee defect with destruction of the medial femoral condyle, including the medial collateral ligament. Treatment included using an anterolateral thigh flap for soft-tissue reconstruction, tensor fasciae latae muscle for ligament repair, and a massive allogenic bone graft of the medial femoral condyle that was revascularized with an osteocutaneous composite free flap from the contralateral femur. At 17 months postoperatively, the outcome was evaluated with scores on several established scales and radiographic assessment.

Conclusion:
The combination of vascularized soft-tissue reconstruction and osseous reconstruction using allogenic bone along with surgical angiogenesis proved to be effective. Complex extremity reconstruction should be discussed with interdisciplinary specialists.
Anatomic Double-Bundle Posterior Cruciate Ligament Reconstruction
Authors: Chahla Jorge , Moatshe Gilbert , Engebretsen Lars , LaPrade Robert F. 
Published: February 2017

The posterior cruciate ligament (PCL) is the main posterior stabilizer of the knee. It is composed of 2 bundles, the larger anterolateral bundle (ALB) and the smaller posteromedial bundle (PMB). The 2 bundles were historically believed to function independently, with the ALB predominantly being an important stabilizer in flexion and the PMB being a stabilizer mainly in extension. However, a recent biomechanical study1 noted a codominant relationship between these 2 bundles. The anatomic single-bundle PCL reconstruction, focusing on reconstruction of the larger ALB, is the most commonly performed procedure. Because of the residual posterior and rotational tibial instability after a single-bundle reconstruction and the inability to restore the normal knee kinematics, an anatomic double-bundle PCL reconstruction has been proposed in an effort to recreate both bundles using the native footprint, thereby restoring the normal knee kinematics. The anatomic double-bundle PCL reconstruction has demonstrated improved subjective and objective patient outcomes with a low complication rate. Indications for PCL reconstruction are isolated symptomatic acute grade-III PCL tears, combined multiligament lesions, or acute grade-III PCL tears combined with repairable meniscal body or root tears. For chronic PCL tears, indications include functional limitations due to the PCL tear (e.g., difficulty with deceleration, incline descent, or stairs) and comparative PCL stress radiographic laxity of >8 mm in a symptomatic patient.
The steps of this procedure include (1) correct patient positioning to allow for good accessibility of both sides of the joint; (2) graft preparation (Achilles tendon [ALB] and tibialis anterior [PMB] allografts are used); (3) creation of femoral tunnels (11 mm for the ALB adjacent to the cartilage and 7 mm for the PMB with a 2-mm bone bridge); (4) tibial tunnel creation (12-mm diameter, 7 mm anterior to the so-called champagne-glass drop-off); (5) graft fixation and tibial graft passage (a metal screw for the ALB and a bioabsorbable screw for the PMB, with the screws away from the bone bridge to avoid bone bridge breakage); and (6) tibial fixation (the grafts are independently fixed with the knee at 90° of flexion (ALB) and extension (PMB) with screws and washers on the medial side of the tibia.
Three prospective randomized studies18,19,23 suggested that, while clinical outcomes are similar between both isolated transtibial reconstruction techniques, the objective measures of postoperative side-to-side posterior translation and objective International Knee Documentation Committee scores were significantly improved with double-bundle compared with single-bundle PCL reconstructions.
Entre la participación y la resistencia: reconstrucción del tejido social desde abajo en el municipio de san carlos Más allá de la lógica de reparación estatal
Authors: Villa Gómez Juan David , Insuasty Rodríguez Alfonso 
Published: February 2017

Se relacionan los hallazgos en torno a los significados y construcciones sociales de los y las participantes del Municipio de San Carlos Antioquia en torno a la reparación estatal de las víctimas del conflicto armado en Colombia (ley 1448); encontramos que no se están desarrollando plenamente procesos reparadores, por el contrario, en algunos casos se evidenciaron acciones re-victimizantes, lo cual, según nuestro concepto, podría implicar barreras en la transición de la guerra a la paz, lareconciliación nacional y la recuperación de las víctimas (Villa Gómez & Insuasty Rodríguez, 2015) & (Villa Gómez & Insuasty Rodríguez, 2016)en Colombia, claves a tener en cuenta en el actual proceso de Negociación y transición del conflicto armado entre la insurgencia de las FARC-EP y el Gobierno nacional, y el posible proceso con la insurgencia del ELN.