bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-7 Restores T Lymphocyte Immunometabolic Failure in Septic Shock Patients through mTOR Activation
Authors: Venet Fabienne , Demaret Julie , Blaise Benjamin J. , Rouget Christelle , Girardot Thibaut , Idealisoa Estellie , Rimmelé Thomas , Mallet François , Lepape Alain , Textoris Julien , Monneret Guillaume 
Published: July 2017

Abstract
T lymphocyte alterations are central to sepsis pathophysiology, whereas related mechanisms remain poorly understood. We hypothesized that metabolic alterations could play a role in sepsis-induced T lymphocyte dysfunction. Samples from septic shock patients were obtained at day 3 and compared with those from healthy donors. T cell metabolic status was evaluated in the basal condition and after T cell stimulation. We observed that basal metabolic content measured in lymphocytes by nuclear magnetic resonance spectroscopy was altered in septic patients. Basal ATP concentration, oxidative phosphorylation (OXPHOS), and glycolysis pathways in T cells were decreased as well. After stimulation, T lymphocytes from patients failed to induce glycolysis, OXPHOS, ATP production, GLUT1 expression, glucose entry, and proliferation to similar levels as controls. This was associated with significantly altered mTOR, but not Akt or HIF-1α, activation and only minor AMPKα phosphorylation dysfunction. IL-7 treatment improved mTOR activation, GLUT1 expression, and glucose entry in septic patients’ T lymphocytes, leading to their enhanced proliferation. mTOR activation was central to this process, because rapamycin systematically inhibited the beneficial effect of recombinant human IL-7. We demonstrate the central role of immunometabolism and, in particular, mTOR alterations in the pathophysiology of sepsis-induced T cell alterations. Our results support the rationale for targeting metabolism in sepsis with recombinant human IL-7 as a treatment option.
Contemplative investigation into Christ consciousness with Heart Prayer and HeartMath practices
Authors: Edwards Stephen D. , Edwards David J. 
Published: July 2017

An exploratory pilot study with a small homogenous sample of Christian English speaking participants (four men and four women, with a mean age of 48 and age range from 27 to 70 years) provided support for an alternative research hypothesis that a Christ consciousness contemplation with Heart Prayer of HeartMath techniques was significantly associated with increasing psychophysiological coherence, sense of coherence, spirituality and health perceptions. Participants described feelings of a peaceful place in oneness and connection with Christ. Integrative findings point towards Christ consciousness as an ultimately non-dual process of sensing vibrational resonance radiating from the human heart. Implications for further research are discussed.
Effects of damaging hydrogeological events on people throughout 15 years in a Mediterranean region
Authors: Aceto Luigi , Pasqua A. Aurora , Petrucci Olga 
Published: July 2017

Abstract. Damaging Hydrogeological Events (DHE) are defined as rainy periods during which landslides and floods can damage people. The paper investigated the effects of DHE on people living in Calabria (southern Italy) in the period 2000–2014, using data coming from the systematic survey of regional newspapers. Data about fatalities, people injured and people involved (not killed neither hurt) were stored in the database named PEOPLE, made of three sections: (1) event identification, (2) victim-event interaction, (3) effects on people. The outcomes highlighted vulnerability factors related to gender and age: males were killed more frequently (75 %) than females (25 %), and fatalities were older (average age 49 years) than injured (40.1 years) and involved people (40.5 years). The average ages of females killed (67.5 years), injured (43.4 years) and involved (44.6 years) were higher than the same values assessed for males, maybe indicating that younger females tended to be more cautious than same-age males, while older females showed an intrinsic greater vulnerability. Involved people were younger than injured people and fatalities, perhaps because younger people show greater promptness to react in dangerous situations. In the study region, floods caused more fatalities (67.9 %), injured (55 %) and involved people (55.3 %) than landslides. Fatalities and injuries mainly occurred outdoor, especially along roads, and the most dangerous dynamic was to be dragged by flood, causing the majority of fatalities (71.4 %). These outcomes can be used to strengthen the strategies aimed at saving people, and to customise warning campaigns according to the local risk features and people's behaviour. The results can improve the understanding of the potential impacts of geo-hydrological hazards on the population and can increase risk awareness among both administrators and citizens.
Democracia e legitimidade nos modelos atuais de controle concentrado de constitucionalidade.
Authors: Lawand Jr. Antonio Elian 
Published: July 2017

A meta deste trabalho é identificar alguns impactos, no universo jurídico e político, das decisões de controle de constitucionalidade concentrado. Para tanto, laboramos com a concepção de Direito em Dworkin e o papel político de construção da norma pelo Juiz. A partir de então, observamos o teor deste impacto à luz da legitimidade das decisões de poder em processo democrático e os instrumentos que a Corte Constitucional Brasileira dispõe para aproximar suas decisões à moral sócio-política da sociedade para o qual presta serviço e obediência. As conclusões cingem-se à verificação de determinados riscos para a Democracia Brasileira decorrente de uma inadequada distorção dos poderes Constituintes Reformadores.
Samuel R. Delany, Lou Reed, and Utopia's Queer End
Authors: Haslam Jason 
Published: July 2017

ABSTRACT
Reading Delany's sword-and-sorcery Nevèrÿon cycle—with a particular focus on the tales collected in Flight from Nevèrÿon, including the AIDS novella The Tale of Plagues and Carnivals (1984)— alongside Lou Reed's songs, this article argues that Delany's fantastic, endlessly queer aesthetic “spaces” offer a complex definition of the queer utopia, one that invokes and demands the future José Esteban Muñoz desires, even as it insists that such a future can only be called into being against the backdrop of the celebration of negation lauded by Lee Edelman. This article aims to reinsert the “abstract” paraliterary utopia into Muñoz's materialist argument, even as it questions the division in queer theory between Muñoz's hopeful desire and Edelman's death-driven polemic. In The Tale of Plagues and Carnivals, the endless play of pleasure and death leads ultimately to a sundering of the division between fantasy and material reality, with the division between Nevèrÿon and the streets of New York (in the opening days of the AIDS pandemic) finally collapsing in the narrative's conclusion, opening into new, queer quantum presents.
A positive readout single transcript reporter for site-specific mRNA cleavage
Authors: Kandul Nikolay , Guo Ming , Hay Bruce A. 
Published: July 2017

Cleavage of mRNA molecules causes their rapid degradation, thereby playing an important role in regulation of gene expression and host genome defense from viruses and transposons in bacterial and eukaryotic cells. Current negative-readout, and repressor-based positive-readout reporters of mRNA degradation have limitations. Here we report the development of a single transcript that acts as a positive reporter of mRNA cleavage. We show that placement of bacterial CopT and CopA hairpins into the 5′ UTR and 3′ UTR of an mRNA results in inhibition of translation of the intervening coding sequence inDrosophila. An internal poly(A) tract inserted downstream of the coding sequence stabilizes transcripts cut within the 3′ UTR. When these components are combined in a transcript in which targets sites for RNA cleavage are placed between the poly(A) tract and CopA, cleavage results in translational activation, providing a single transcript-based method of sensing mRNA cleavage with a positive readout.
Idiopathic Pulmonary Fibrosis Caused by Damaged Mitochondria and Imbalanced Protein Homeostasis in Alveolar Epithelial Type II Cell
Authors: Dong Zhaoxiong , Wang Xiaolong , Wang Peiwen , Bai Mingjian , Wang Tianyu , Chu Yanhui , Qin Yan 
Published: October 2024

AbstractAlveolar epithelial Type II (ATII) cells are closely associated with early events of Idiopathic pulmonary fibrosis (IPF). Proteostasis dysfunction, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction are known causes of decreased proliferation of alveolar epithelial cells and the secretion of pro‐fibrotic mediators. Here, a large body of evidence is systematized and a cascade relationship between protein homeostasis, endoplasmic reticulum stress, mitochondrial dysfunction, and fibrotropic cytokines is proposed, providing a theoretical basis for ATII cells dysfunction as a possible pathophysiological initiating event for idiopathic pulmonary fibrosis.
Improved Charge Recombination Efficiency in Organic Light‐Emitting Transistors via Luminescent Radicals
Authors: Reginato Francesco , Lunedei Eugenio , Mattiello Sara , Baroni Giulia , Bolognesi Margherita , Porcelli Francesco , Mattioli Giuseppe , Hattori Yohei , Prosa Mario , Beverina Luca , Toffanin Stefano 
Published: October 2024

AbstractLuminescent radicals are attracting attention as emitters in electroluminescent devices thanks to the exploitation of doublet excitons. Recent studies reveal that exciton formation in radical organic light‐emitting diodes (OLEDs) primarily occurs through a charge trapping mechanism. Although typically detrimental for OLEDs, this might be a key process to elucidate light emission in organic light‐emitting transistors (OLETs). Here, a unipolar n‐type architecture suitable for the implementation of radical emitters is introduced, designed based on computational calculations. The operation of the as‐realized devices incorporating the newly synthesized [2,6‐dichloro‐4‐(2,6‐dimethoxyphenyl)phenyl](3,5‐dichloro‐4‐pyridyl) (2,4,6‐trichlorophenyl)methyl radical is investigated via transient electroluminescence measurements to demonstrate the occurrence of long‐living emission ascribed to the charge trapping mechanisms. Moreover, a comprehensive understanding of the processes governing radical‐OLET is obtained by recording complete 2D maps of both optical and electrical response of the device as a function of applied voltages. Notably, the trapping of electrons by radical moieties is demonstrated to generate a negative charge density in the emissive layer that facilitates holes to be injected: increasing the balance of opposite charge carriers, a tenfold enhancement of the external quantum efficiency (EQE) at the proper source‐drain and source‐gate voltage conditions is reported to reach a maximum EQE value of 0.2%.
Molecularly and Structurally Designed Polyimide Nanofiber Radiative Cooling Films for Spacecraft Thermal Management
Authors: Song Xiaokun , Gong Hao , Li Hongchao , Zhang Manyao , Jiang Lin , Wang Chao , Jiang Peipei , Wang Huifen , Cao Kangli , Liu Gang , Zhao Qibin , Fan Tongxiang 
Published: October 2024

AbstractRadiative cooling films (RCFs) are crucial for spacecraft thermal management, but their optical performance is currently limited by their structures and intrinsic high absorption at short wavelengths. In this study, a novel RCF using electrospun polyimide nanofibers optimized at both the molecular and microscale levels is developed. The newly designed polyimide molecules significantly decrease visible and ultraviolet (UV) light absorption while maintaining excellent thermal radiation properties in the infrared spectrum. By optimizing the diameter and orientation of the nanofibers using Monte Carlo simulations, the resulting film achieves a solar reflectivity of 99.6% and a mid‐infrared emissivity of 0.93. Its physical structures and optical properties remain stable under exposure to UV light, atomic oxygen, and extreme temperature changes. Further vacuum radiative cooling tests reveal that the thermal equilibrium temperature of this film is approximately 28 °C lower than that of Kapton‐based RCFs currently used in spacecraft. These results provide a new approach for creating efficient thermal management materials for space applications, with potential for broader use in architecture, electronic devices, and outdoor equipment.
Visual and Gravimetric CO2 Sensing at High Humidity Levels Enabled by MOF‐804 Cofunctionalized with Ionic Liquid and m‐Cresol Purple
Authors: Xu Xiaoyi , Zhou Tingting , Bing Yu , Wang Xukun , Jiang Hongtao , Song Zhao , Zhang Tong 
Published: October 2024

AbstractReal‐time monitoring of carbon dioxide (CO2) is imperative for medical diagnosis and effective environmental preservation. Despite the formidable challenge posed by the inherent chemical inertness of CO₂ molecules, a pioneering CO2 sensor based on MOF‐804 cofunctionalized with ionic liquid (IL) and m‐cresol purple (mCP) is successfully developed. By ingeniously integrating hydrogen bonding, electrostatic interactions, and hydrophobic properties within the sensitive layer, the sensor achieves a state‐of‐the‐art sensitivity (Δf = 384 Hz), an exceptionally vast detection range spanning 400–80 000 ppm, and remarkable stability with minimal sensitivity drift even at relative humidity (RH) levels exceeding 80%. Furthermore, the inherent gasochromic property, stemming from the zwitterionic mechanism, paves the way for innovative self‐sustaining CO2 test strips and groundbreaking applications, including CO2 tracking and CO2‐encrypted security labeling technology. Collectively, the realization of this ultra‐sensitive and robust CO2 monitoring approach, coupled with its CO2‐triggered visual and multifunctional capabilities, opens up novel avenues for dynamic CO2 detection, advanced military encryption strategies, and enhanced health management systems.
Enhanced Salinity Gradient Energy Conversion by Photodegradable MXene/TiO2 Membrane Utilizing Saline Dye Wastewater
Authors: Li Mengjie , Zhang Wanlu , Geng Yutong , Lu Bingxin , He Jianwei , Liu Jun , Li Xuejiang , Zhou Hangjian , Fan Xia , Zhai Jin 
Published: October 2024

AbstractThe utilization of nanochannel membranes for harvesting salinity gradient energy has shown promising potential in addressing the energy crisis and environmental pollution issues. While previous studies have mainly focused on extracting salinity energy from mixing artificial seawater with river water, the research introduces a creative approach involving dye wastewater treatment using MXene/TiO2 membranes to achieve simultaneous photocatalytic degradation and power generation via salinity gradients. The built‐in electric field generated by MXene/TiO2 heterojunctions enhances ionic transport and electron‐hole separation. After photocatalytic treatment of saline dye wastewater, the membrane is defined as a photodegradable membrane. This membrane exhibits increased surface charge and expanded layer spacing to optimize salinity gradient energy conversion efficiency, yielding an impressive power density of up to 11.78 W m−2, which is 20% higher than that of the original MXene/TiO2 membrane. This work offers valuable insights into the development of multifunctional materials for sustainable power generation that comprehensively utilize industrial wastewater and domestic sewage.
Synergistic Dual‐Additive Tailored Robust Interphase toward Enhanced Cyclability of Prussian Blue Cathode for K+ Storage
Authors: Wang Zixing , Luo Kang , Mo Ying , Ke Jinlong , Zhou Wang , Chen Shi , Gao Peng , Liu Jilei 
Published: October 2024

AbstractFe‐based Prussian blue analogs (KFeHCF) are considered as the most promising cathode materials for potassium‐ion batteries (KIBs) owing to their low cost and high energy density. However, the unstable cathode electrolyte interphase (CEI) typically leads to rapid capacity decay upon long‐term cycling, thus limiting its practical application. Herein, for the first time, a dual‐additive strategy has been proposed as an effective and economical approach to regulate the interphase chemistry on KFeHCF surface. The optimized contents of potassium selenocyanate (KSeCN, 0.5 wt.%) and lithium difluoro(oxalato)borate (LiDFOB, 0.5 wt.%) synergistically lead to the formation of a robust, homogeneous, and conductive CEI film, which promote charge transfer and K+ diffusion, inhibit side reactions and Fe dissolution, and realize stabilization of KFeHCF structure upon long cycling. As a result, the K∥KFeHCF battery with 0.5 wt.% LiDFOB + 0.5 wt.% KSeCN addition exhibits significantly improved cycling performance with a high capacity retention ratio of 81.5% after 5000 cycles at 500 mA g−1 current density and 4.5 V cutoff voltage. This study provides a new paradigm for designing high performance potassium‐ion battery via dual electrolyte additive incorporation.
Infrared Light Activated Highly Efficient Cell Therapy Using Flower‐Shaped Microstructure Device
Authors: Shinde Ashwini Surendra , Shinde Pallavi , Nagai Moeto , Kar Srabani , Santra Tuhin Subhra 
Published: October 2024

AbstractIn this pioneering study, an infrared light‐activated highly efficient and uniform, small to large biomolecular delivery into various cell types is developed using a flower‐shaped microstructure device (FMD). Featuring a unique structural design, this FMD consists of 8 µm in length, with edges of ≈3 and 20 µm gaps between FMD microstructure. When subjected to IR laser exposure at 1050 nm, the FMD triggers the generation of photothermal cavitation bubbles, exerting jet fluid flow on the cell's plasma membrane surface, and facilitating biomolecule delivery into cells. The platform achieves efficient intracellular delivery spanning various biomolecules — from low‐molecular‐weight propidium iodide dye to higher molecular weight siRNA, plasmid, and enzymes — across human cervical (SiHa), mouse fibroblast (L929), and neural crest‐derived (N2a) cancer cells, ensuring consistently high efficiency without compromising cell viability. 95% delivery efficacy and 96% cell viability are achieved for smaller molecules like PI dye in L929 cells. For larger biomolecules such as enzymes, transfection efficiency reached 82%, and cell viability is nearly 90% in SiHa cells. This is confirmed via confocal microscopy and flow cytometry, the FMD‐based delivery system holds broad potential for cellular diagnostics and therapeutics, promising significant advancements in cellular research and biomedical treatments.
Amorphous In–Al–Sn–O Thin Film Transistors and Their Application in Optoelectronic Artificial Synapses
Authors: Feng Xiao , Zhang Yu , Zhuang Xinming , Feng Xianjin 
Published: October 2024

AbstractIn‐Al‐Sn‐O (IATO) is a very promising novel amorphous oxide as the active layer of thin film transistors (TFTs). Herein, IATO TFTs are first fabricated with the effects of annealing on IATO films and TFTs being studied. The IATO films possessed amorphous structure, flat surface morphology, high visible light transmittance, and wide optical bandgap ≈4.20 eV before and after annealing even at 400 °C. The minimal surface roughness and internal defects are obtained for the 300 °C annealed IATO film. Correspondingly, the 300 °C annealed TFTs demonstrated the best overall performance including high saturation mobility (8.55 ± 0.62 cm2 V−1 s−1), low subthreshold swing (0.40 ± 0.07 V dec−1), ideal on/off current ratio (1.25 ± 0.09 × 108), and negligible hysteresis (0.23 ± 0.03 V) values. The 300 °C annealed TFTs are then applied in optoelectronic artificial synapses and exhibit typical synaptic properties, including excitatory postsynaptic current, paired‐pulse facilitation, and short‐term plasticity to long‐term plasticity conversion in response to light stimulation. The international Morse code and repetitive learning‐forgetting behavior of the human brain are also successfully simulated. In particular, an emotion‐memory efficiency model is proposed and the emotion effect on human memory efficiency is successfully imitated via the regulation of gate voltage.
Achieving the Dendrite‐Free Zn Anode by Inducing the (101)‐Preferred Electrodeposition of Zn Crystals
Authors: Ren Qingqing , Tang Xinyue , Guo Yaqing , Liao Xiaobin , Zhang Congmin , Zhu Zixuan , Wang Panpan , Wang Wei , Li Yun , Song Wenjun , Wang Shun , He Kun , Wang Zhen‐Bo , Yuan Yifei 
Published: October 2024

AbstractPrevious studies have primarily focused on promoting the (002) crystal plane of electrodeposited zinc (Zn) to grow thin Zn plates parallel to the electrode surface and thus achieving the dendrite‐suppressed Zn anodes. In contrast, this work adopts a novel approach. In situ construct a tin (Sn) modification layer on Zn foil. Through in‐depth cross‐sectional morphological analyses, the as‐designed Sn interface is observed to induce (101)‐preferred electrodeposition of Zn, leading to well‐ordered alignment of Zn thin plates “standing‐up” against the electrode surface at a universal angle of 65°. Such crystallographic characteristic consequently guarantees a flat and compact morphology of the electrochemically deposited Zn layer, thus suppressing the notorious problems of dendritic Zn growth and hydrogen generation. Consequently, the dendrite‐free Sn–Zn anode exhibits long‐term cycling stability of 4000 h at 1 mA cm−2 and 0.5 mAh cm−2, a significant improvement in comparison to the 50 h stability observed for unmodified Zn anode. The findings in this study offer a deep understanding of interface mechanisms and are instructive for innovative interface design for metal anodes.
Intratumoral microbiota as cancer therapeutic target
Authors: Guo Chang , An Qi , Zhang Lu‐yao , Wei Xun‐dong , Xu Jing , Yu Jiang‐yong , Wu Guo‐ju , Ma Jie 
Published: October 2024

AbstractIntratumoral microbiota, which affects the physiological and pathological processes of the host, has attracted increasing attention from researchers. Microbials have been found in normal as well as tumor tissues that were originally thought to be sterile. Intratumoral microbiota is considered to play a significant role in the development of tumors and the reduction of clinical benefits. In addition, intratumoral microbiota are heterogeneous, which have different distribution in various types of tumors, and can influence tumor development through different mechanisms, including genome mutations, inflammatory responses, activated cancer pathways, and immunosuppressive microenvironments. Therefore, eliminating the intratumoral microbiota is considered one of the most promising ways to slow down the tumor progression and improve therapeutic outcomes. In this review, we systematically categorized the intratumoral microbiota and elucidated its role in the pathogenesis and therapeutic response of cancer. We have also described the novel strategies to mitigate the impact of tumor progression. We hope this review will provide new insights for the anti‐tumor treatment, particularly for the elderly population, where such insights could significantly enhance treatment outcomes.