bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of mood in aphasia following stroke: validation of the Dynamic Visual Analogue Mood Scales (D-VAMS)
Authors: Barrows Paul D , Thomas Shirley A 
Published: June 2017

Objectives: To validate a non-verbal self-report measure of mood – the Dynamic Visual Analogue Mood Scales (D-VAMS) – against the Hospital Anxiety and Depression Scale (HADS) and assess its suitability as an outcome measure or screening measure for depressed mood following stroke. Design: Cross-sectional observational cohort study. Participants: Forty-six stroke survivors (24% with aphasia) recruited from online, from stroke clubs and via an NHS rehabilitation service. Methods: A set of seven bipolar scales was developed enabling users to report mood by modifying facial expression images using a slider. Participants completed a tablet/computer task, reporting their mood on these scales mixed randomly with versions which used only words. The HADS was then completed, followed by a repeat run of the two versions in a different, random sequence. Results: Exploratory factor analysis identified one factor consistent with pleasantness of mood accounting for 80% of the variance. Internal consistency of D-VAMS was high ( α = 0.95), and there was a high correlation between face-only D-VAMS scores and HADS total scores ( r = −0.80, P < 0.001), as well as HADS-D/HADS-A subscale scores ( r = −0.73, P < 0.001; r = −0.71, P < 0.001). D-VAMS showed good sensitivity and specificity against HADS, with means of 85%/77% (sensitivity/specificity) against the HADS-D and 80%/77% against the HADS-A across nine cut-offs. Conclusion: D-VAMS is a valid and reliable measure likely suitable for assessment of depressed mood in aphasia following stroke. Though D-VAMS performed well as a screening measure in this study sample, further study is needed in the acute stage post-stroke.
Rapid liver and spleen stiffness improvement in compensated advanced chronic liver disease patients treated with oral antivirals
Authors: Pons Mònica , Santos Begoña , Simón-Talero Macarena , Ventura-Cots Meritxell , Riveiro-Barciela Mar , Esteban Rafael , Augustin Salvador , Genescà Joan 
Published: June 2017

Background We aimed to investigate the early changes in liver and spleen stiffness measurement (LSM, SSM) in hepatitis C virus (HCV) patients with compensated advanced chronic liver disease (cACLD) treated with new antivirals (DAA) to elucidate factors determining the initial change in stiffness and its implications for the long-term follow up of HCV-cured patients. Methods: A total of 41 patients with cACLD who started DAA therapy underwent LSM and SSM at baseline, week 4, end of treatment (EOT), 24 and 48 weeks of follow up using transient elastography. Results: LSM improved rapidly during the first 4 weeks of treatment (baseline: 20.8kPa; week 4: 17.5kPa, p = 0.002), with no significant changes between week 4 and EOT (18.3kPa, p = 0.444) and between EOT and 48-week follow up (14.3kPa, p = 0.148). Likewise, SSM improved rapidly (baseline: 45.7kPa; week 4: 33.8kPa, p = 0.047), with no significant changes between week 4 and EOT (30.8kPa, p = 0.153) and between EOT and 48-week follow up (31.2kPa, p = 0.317). A higher decrease in LSM was observed in patients with baseline ALT ⩾ twofold upper limit normal (2 × ULN) than in those with ALT < 2 × ULN (–5.7kPa versus –1.6kPa). Patients who presented a decrease in LSM ⩾ 10% during treatment compared with those with LSM < 10% decrease, showed lower SSM values, higher platelet counts and lower bilirubin levels at 24-week follow up. Those with decrease in SSM ⩾ 10%, presented a higher increase in platelets than those with SSM < 10% change ( p = 0.015). Conclusions: LSM and SSM decrease very rapidly during DAA treatment in cACLD patients suggesting that it most probably reflects a reduction in inflammation rather than in fibrosis. cACLD patients should be maintained under surveillance independently of stiffness changes, because advanced fibrosis can still be present.
Acceptability and willingness to pay for telemedicine services in Enugu state, southeast Nigeria
Authors: Arize Ifeyinwa , Onwujekwe Obinna 
Published: June 2017

Background This study examines the level of awareness, acceptability and consumers’ willingness to pay (WTP) for telemedicine services using the contingent valuation method (CVM). This work is important as it elicits the value that consumers attach to telemedicine given there is a gap in this knowledge in many sub-Saharan countries such as in Nigeria. Methods The study was based on primary data obtained through an interviewer-administered questionnaire of 370 individuals including both males and females from 25 years and over, to collect data on respondents’ awareness of, acceptability of, and WTP for telemedicine, using the bidding game question format. A socioeconomic status (SES) index was created, based on information on household assets, and was used to categorize respondents into SES quartiles. The data were analyzed using a combination of descriptive techniques, logistics and the Tobit regression model (Tobit Type 1) methods. Results The study found that majority of the people (58.9%) had no knowledge of telemedicine. However, 48.7% of the respondents were willing to pay for telemedicine. The mean WTP for a telemedicine was US$2.04 for each visit. Tobit regression analysis showed that respondents’ socioeconomic status (SES) was the main statistically significant variable that explained their WTP for telemedicine. Conclusion The study has shown that there is a low-level awareness of and WTP for telemedicine services in Enugu State, South East of Nigeria. The finding of a positive relationship between SES and WTP implies that the poor may not be able to pay for telemedicine and may need government subsidies to be able to benefit from such service. Also, government and their partners need to undertake wide scale campaign before the introduction of telemedicine.
Low-Fat Dietary Pattern and Breast Cancer Mortality in the Women’s Health Initiative Randomized Controlled Trial
Authors: Chlebowski Rowan T. , Aragaki Aaron K. , Anderson Garnet L. , Thomson Cynthia A. , Manson JoAnn E. , Simon Michael S. , Howard Barbara V. , Rohan Thomas E. , Snetselar Linda , Lane Dorothy , Barrington Wendy , Vitolins Mara Z. , Womack Catherine , Qi Lihong , Hou Lifang , Thomas Fridtjof , Prentice Ross L. 
Published: June 2017

Purpose Earlier Women’s Health Initiative Dietary Modification trial findings suggested that a low-fat eating pattern may reduce breast cancers with greater mortality. Therefore, as a primary outcome-related analysis from a randomized prevention trial, we examined the long-term influence of this intervention on deaths as a result of and after breast cancer during 8.5 years (median) of dietary intervention and cumulatively for all breast cancers diagnosed during 16.1 years (median) of follow-up. Patients and Methods The trial randomly assigned 48,835 postmenopausal women with normal mammograms and without prior breast cancer from 1993 to 1998 at 40 US clinical centers to a dietary intervention with goals of a reduction of fat intake to 20% of energy and an increased intake of fruits, vegetables, and grains (40%; n = 19,541) or to a usual diet comparison (60%; n = 29,294). Results In the dietary group, fat intake and body weight decreased (all P < .001). During the 8.5-year dietary intervention, with 1,764 incident breast cancers, fewer deaths occurred as a result of breast cancer in the dietary group, which was not statistically significant (27 deaths [0.016% per year] v 61 deaths [0.024% per year]; hazard ratio [HR], 0.67; 95% CI, 0.43 to 1.06; P = .08). During the same period, deaths after breast cancer (n = 134) were significantly reduced (40 deaths [0.025% per year] v 94 deaths [0.038% per year]; HR, 0.65; 95% CI, 0.45 to 0.94; P = .02) by the dietary intervention. During the 16.1-year follow-up, with 3,030 incident breast cancers, deaths after breast cancer also were significantly reduced (234 deaths [0.085% per year] v 443 deaths [0.11% per year]; HR, 0.82; 95% CI, 0.70 to 0.96; P = .01) in the dietary group. Conclusion Compared with a usual diet comparison group, a low-fat dietary pattern led to a lower incidence of deaths after breast cancer.
A Reinterpretation of the Optimal Demand for Risky Assets in Fund Separation Theorems
Authors: Deguest Romain , Martellini Lionel , Milhau Vincent 
Published: June 2017

In a continuous-time portfolio selection model with N risky assets and K state variables driving their risk and return parameters, we derive simple expressions for the allocation to each asset in the K + 1 risky funds of the (K + 2)-fund separation theorem. We show that the allocation to any given risky asset in each fund can be written in terms of the parameters of a regression of the excess returns of this asset on those of the N − 1 remaining assets. We also use these parameters to provide quantitative measures of the increase in Sharpe ratio of the speculative demand, or in the maximum correlation of each hedging demand with respect to the corresponding risk factor, associated with the introduction of a new asset in the investment universe. Finally, we show that in a multiperiod setting, an asset is “spanned” by others if and only if it improves neither the maximum Sharpe ratio of the speculative demand nor the maximum correlations of the hedging demands with the risk factors. This paper was accepted by Lauren Cohen, finance.
Apuntes: Sobre Editores y poliíticas editoriales en Argentina (1880–2010), de José Luis de Diego (director). Buenos Aires: Fondo de Cultura Económica, 2014; y La otra cara de Jano. Una mirada crítica sobre el libro y la edición, de José Luis de Diego. Buenos Aires: Ampersand, 2015
Authors: Tosti Ivana 
Published: June 2017

Reseña de Editores y políticas editoriales en Argentina (1880–2010), de José Luis de Diego (director). Buenos Aires: Fondo de Cultura Económica, 2014; y La otra cara de Jano. Una mirada crítica sobre el libro y la edición, de José Luis de Diego. Buenos Aires: Ampersand, 2015.
CONTENIDO DE CARBONO EN UN BOSQUE DE TIERRA FIRME DEL RESGUARDO NONUYA-VILLAZUL, AMAZONIA COLOMBIANA
Authors: Paky Barbosa Edwin , Moreno Fabian , Londño-Vega Ana Catalina , Alvarez-Dávila Esteban 
Published: June 2017

La implementación de los programas REDD+ requiere estimaciones precisas del carbono forestal. En este estudio se reporta el contenido de carbono en un bosque de tierra firme del resguardo Villazul-Nonuya RVN de la Amazonia colombiana, con base en una parcela permanente de 6 ha. Se evalúa su variación espacial y la contribución del sotobosque, dos factores poco considerados. Se encontró una biomasa promedio total de 336.1±14.0 t.ha-1; el 11.5% se encuentra en el sotobosque (DAP 1-10 cm) y el 88.5% corresponde a árboles con DAP ≥ 10 cm; los árboles grandes (DAP ≥ 70 cm) son pocos (4 ±1 por ha) y tienen una baja contribución a la biomasa (6.8%) en comparación con otros bosques tropicales. La biomasa promedio estimada está dentro del rango reportado para toda la cuenca Amazónica, es superior a la Amazonia Occidental y similar al de Amazonia colombiana. Considerando que el resguardo VN tiene 208 800 ha en bosques de tierra firme, se estimó un promedio total de 31.0 Mt C (95% IC 29.1-32.04). Estos resultados permiten ubicar a los bosques del resguardo VN en un contexto global y mejorar la precisión de las estimaciones de carbono forestal en la Amazonia colombiana.
Validity of Retrospective Session Rating of Perceived Exertion to Quantify Training Load in youth Athletes
Authors: Scantlebury Sean , Till Kevin , Sawczuk Tom , Phibbs Padraic , Jones Ben 
Published: June 2017

Abstract
Scantlebury, S, Till, K, Sawczuk, T, Phibbs, P, and Jones, B. Validity of retrospective session rating of perceived exertion to quantify training load in youth athletes. J Strength Cond Res 32(7): 1975–1980, 2018—Youth athletes frequently participate in multiple sports or for multiple teams within the same sport. To optimize player development and minimize undesirable training outcomes (e.g., overuse injuries), practitioners must be cognizant of an athlete's training load within and outside their practice. This study aimed to establish the validity of a 24-hour (s-RPE24) and 72-hour (s-RPE72) recall of session rating of perceived exertion (s-RPE) against the criterion measure of s-RPE collected 30 minutes' post training (s-RPE30). Thirty-eight adolescent athletes provided a s-RPE30 following the first field based training session of the week. Approximately 24 hours later subjects were asked to recall the intensity and duration of the previous days training. The following week subjects once again provided an s-RPE30 measure after training before recalling the intensity and duration of the session approximately 72 hours later. A nearly perfect correlation (0.98 [0.97–0.99]) was found between s-RPE30 and s-RPE24, with a small typical error of estimate (TEE; 8.3% [6.9–10.5]) and trivial mean bias (−1.1% [−2.8 to 0.6]). Despite a large correlation between s-RPE30 and s-RPE72 (0.73 [0.59–0.82]) and a trivial mean bias (−0.2% [−6.8 to 6.8]), there was a large TEE (35.3% [29.6–43.9]). s-RPE24 provides a valid measure of retrospectively quantifying s-RPE; however, the large error associated with s-RPE72 suggests that it is not a suitable method for monitoring training load in youth athletes.
El proceso de construcción de la memoria de los años cincuenta en Colombia
Authors: Valencia Gutiérrez Alberto 
Published: June 2017

Este artículo muestra en qué consiste el proceso de construcción de la memoria de La Violencia de los años cincuenta (el periodo del enfrentamiento a muerte entre liberales y conservadores), proceso que se llevó a cabo durante el Frente Nacional. El artículo parte de la idea de que desde el momento en que la memoria pasa a un primer plano en los ámbitos internacional y nacional es necesario leer con esta clave los acontecimientos de la vida política. Más aún, se considera que la memoria no es una simple búsqueda de la verdad de lo sucedido, sino una elaboración al servicio de múltiples intereses políticos, tanto de liberación como de dominación, en la que toman parte las víctimas y los victimarios. En este texto, se identifican tres campos de elaboración de la memoria y se definen tres formas de rememoración desde el Frente Nacional: la memoria de las múltiples recriminaciones entre conservadores y liberales; la representación de La Violencia como una forma de cataclismo social, a la manera de una fuerza impersonal y ciega; y la consideración de la época como una cruel dictadura, que funciona como un recuerdo encubridor de las atrocidades cometidas. En la construcción de esta última forma de memoria, la gran prensa desempeñó un papel fundamental, con el periódico El Tiempo a la cabeza. La conclusión es que La Violencia no ha encontrado una verdadera integración en la trama de la historia nacional y que el Frente Nacional puso en marcha un proceso de invención de la desmemoria que ha hecho ininteligible lo sucedido para las nuevas generaciones.
Músicas populares en Cali en los años setenta: dinámicas del campo de producción cultural
Authors: Cano Molina Paola Andrea 
Published: June 2017

Este artículo presenta los resultados de investigación sobre las músicas populares originadas en Cali durante los años setenta y las dinámicas del campo de producción cultural. Se trata de una aproximación que permite caracterizar los procesos de produccióny circulación de los géneros musicales que fueron divulgados, principalmente, a través de medios de comunicación, en un periodo histórico de intensas transformaciones en la ciudad. Así, este estudio se concentra en los actores, las dinámicas sociales y los productos culturales de la balada romántica, el rock y las músicas bailables, que estructuraron un campo cultural con características propias. La metodología del estudio tuvo un enfoque cualitativo con un diseño documental que permitió analizar e interpretar la urdimbre de acciones, sentidos e intereses que configuran el fenómeno (Bonilla-Castro y Rodríguez, 1997). Se realizó una revisión extensa de prensa correspondiente a la década de los añossetenta en un diario local y se examinaron otros documentos, como fotografías y material bibliográfico. De manera complementaria, se realizaron doce entrevistas semiestructuradas, guiadas por los objetivos del trabajo. A partir del análisis de dicha información,se evidenciaron diferencias en los capitales económicos acumulados en los tres géneros estudiados. Se concluyó que las dinámicas de producción cultural en los años setenta son muestra de la manera en que las músicas se relacionan con diferentes culturas y clasessociales (Frith, 1987) y señalan ciertas conexiones entre etnicidad, clase y sonido, lo que plantea otra forma de leer el tema en ese periodo. De igual forma, indican que la dinámica de producción cultural estaba relacionada con las pocas posibilidades que ofrecía laciudad en términos de recursos tecnológicos para la grabación y difusión de las músicas populares.
A háromdimenziós power Doppler-indexek és a perinatalis kimenetel vizsgálata méhen belüli növekedési restrikcióval szövődött terhességekben
Authors: Molnár András , Surányi Andrea , Jakó Mária , Nyári Tibor , Németh Gábor 
Published: June 2017

Abstract: Introduction: Development of intrauterine growth restriction (IUGR) can be traced back to maternal or fetal factors, but in many cases we find placental factors (reduced placental circulation) in the background. Aim: Our aim was to examine whether the reduced placental bloodperfusion and vascularity show any correlation with cesarean section frequency and the clinical outcome in IUGR pregnancies. The aim of the present study was also to use a properly calibrated and reproducible method for evaluating placental blood flow, that can later be incorporated into the routine examination. Method: 254 women were recruited in our prospective case-control study. The 3 dimensional power Doppler (3DPD) ultrasound indices; vascularisation index (VI), flow index (FI) and vascularization flow index (VFI) were measured on each participant. Results: Median VI was 3.7% (interquartile range [IQR] 3.2%–4.2%) in the IUGR group and 10.1% (IQR 8.6%–10.9%) in the control group (p = 0.001). Median FI value was 40.0 (IQR 39.7–42.5) in the IUGR group and 45.1 (IQR 44.1–53.1) in the control group (p = 0.012). Median VFI was 2.2 (IQR 2.1–2.4) in the IUGR group and 4.8 (IQR 4.4–5.3) in the control. Conclusions: The 3DPD indices may be useful for examining changes in circulation in IUGR pregnancies to characterize the underlying pathology. Orv Hetil. 2017; 158(26): 1008–1013.
Palbociclib Combined with Fulvestrant in Premenopausal Women with Advanced Breast Cancer and Prior Progression on Endocrine Therapy: PALOMA-3 Results
Authors: Loibl Sibylle , Turner Nicholas C. , Ro Jungsil , Cristofanilli Massimo , Iwata Hiroji , Im Seock-Ah , Masuda Norikazu , Loi Sherene , André Fabrice , Harbeck Nadia , Verma Sunil , Folkerd Elizabeth , Puyana Theall Kathy , Hoffman Justin , Zhang Ke , Bartlett Cynthia Huang , Dowsett Mitchell 
Published: June 2017

Abstract

Background
The efficacy and safety of palbociclib, a cyclin-dependent kinase 4/6 inhibitor, combined with fulvestrant and goserelin was assessed in premenopausal women with advanced breast cancer (ABC) who had progressed on prior endocrine therapy (ET).

Patients and Methods
One hundred eight premenopausal endocrine-refractory women ≥18 years with hormone receptor–positive (HR+)/human epidermal growth factor receptor 2–negative (HER2−) ABC were among 521 women randomized 2:1 (347:174) to fulvestrant (500 mg) ± goserelin with either palbociclib (125 mg/day orally, 3 weeks on, 1 week off) or placebo. This analysis assessed whether the overall tolerable safety profile and significant progression-free survival (PFS) improvement extended to premenopausal women. Potential drug-drug interactions (DDIs) and ovarian suppression with goserelin were assessed via plasma pharmacokinetics and biochemical analyses, respectively. (ClinicalTrials.gov identifier: NCT01942135)

Results
Median PFS for premenopausal women in the palbociclib (n = 72) versus placebo arm (n = 36) was 9.5 versus 5.6 months, respectively (hazard ratio, 0.50, 95% confidence interval: 0.29–0.87), and consistent with the significant PFS improvement in the same arms for postmenopausal women. Any-grade and grade ≤3 neutropenia, leukopenia, and infections were among the most frequent adverse events reported in the palbociclib arm with concurrent goserelin administration. Hormone concentrations were similar between treatment arms and confirmed sustained ovarian suppression. Clinically relevant DDIs were not observed.

Conclusion
Palbociclib combined with fulvestrant and goserelin was an effective and well-tolerated treatment for premenopausal women with prior endocrine-resistant HR+/HER2− ABC. Inclusion of both premenopausal and postmenopausal women in pivotal combination ET trials facilitates access to novel drugs for young women and should be considered as a new standard for clinical trial design.
Hematological profile of children with severe acute malnutrition: a tertiary care centre experience
Authors: Arya Arun Kumar , Kumar Pramod , Midha Tanu , Singh Mahendra 
Published: June 2017

Background: Severe acute malnutrition (SAM) is associated with various pathophysiological changes in the body including hematological system. This study was done to understand the hematological profile of severely malnourished children.Methods: This case control study was conducted in the Department of pediatrics, G.S.V.M. Medical College, Kanpur from January 2014 to December 2015. 200 children, aged 6 months- 5years admitted to our hospital with SAM were enrolled as cases. 200 children with normal nutritional status without haematological or infectious conditions attending routine clinic were selected as controls. The hematological parameters were analyzed using an automated blood Analyzer.Results: 95% of the children with SAM had anemia, out of which 52% were severely anemic and 28% were moderately anemic. Mean value for hemoglobin was lower in test group (7.17±2.265gm/dl) as compared to control group (9.22±3.362gm/dl). Children with SAM had statistically significant lower mean values for red cell indices like RBC counts, MCV, MCH and MCHC compared to controls. The mean value of WBC in SAM children was 12.1±11.5×103, while it was 6.2± 7.8×103 in controls. The cases had higher mean value for neutrophils and lower mean value for lymphocytes.Conclusions: Children with SAM had lower mean hemoglobin, hematocrit and red cell indices and higher mean value of total leukocyte and platelet counts. This study recommends that more frequent studies should be done to describe the trend of hematopoietic changes in children with SAM to enhance anticipatory care and outcome of the affected children.