bluuebunny/crossref_metadata_2025_split huggingface dataset:
Red blood cell transfusion triggers in acute leukemia: a randomized pilot study
Authors: DeZern Amy E. , Williams Katherine , Zahurak Marianna , Hand Wesley , Stephens R. Scott , King Karen E. , Frank Steven M. , Ness Paul M. 
Published: May 2016

BACKGROUNDRed blood cell (RBC) transfusion thresholds have yet to be examined in large randomized trials in hematologic malignancies. This pilot study in acute leukemia uses a restrictive compared to a liberal transfusion strategy.STUDY DESIGN AND METHODSA randomized (2:1) study was conducted of restrictive (LOW) hemoglobin (Hb) trigger (7 g/dL) compared to higher (HIGH) Hb trigger (8 g/dL). The primary outcome was feasibility of conducting a larger trial. The four requirements for success required that more than 50% of the eligible patients could be consented, more than 75% of the patients randomized to the LOW arm tolerated the transfusion trigger, fewer than 15% of patients crossed over from the LOW arm to the HIGH arm, and no indication for the need to pause the study for safety concerns. Secondary outcomes included fatigue, bleeding, and RBCs and platelets transfused.RESULTSNinety patients were consented and randomly assigned to LOW to HIGH. The four criteria for the primary objective of feasibility were met. When the number of units transfused was compared, adjusting for baseline Hb, the LOW arm was transfused on average 8.0 (95% confidence interval [CI], 6.9‐9.1) units/patient while the HIGH arm received 11.7 (95% CI, 10.1‐13.2) units (p = 0.0003). There was no significant difference in bleeding events or neutropenic fevers between study arms.CONCLUSIONThis study establishes feasibility for trial of Hb thresholds in leukemia through demonstration of success in all primary outcome metrics and a favorable safety profile. This population requires further study to evaluate the equivalence of liberal and restrictive transfusion thresholds in this unique clinical setting.
Efficient Deduplication in a Distributed Primary Storage Infrastructure
Authors: Paulo João , Pereira José 
Published: May 2016

A large amount of duplicate data typically exists across volumes of virtual machines in cloud computing infrastructures. Deduplication allows reclaiming these duplicates while improving the cost-effectiveness of large-scale multitenant infrastructures. However, traditional archival and backup deduplication systems impose prohibitive storage overhead for virtual machines hosting latency-sensitive applications. Primary deduplication systems reduce such penalty but rely on special cluster filesystems, centralized components, or restrictive workload assumptions. Also, some of these systems reduce storage overhead by confining deduplication to off-peak periods that may be scarce in a cloud environment.
We present DEDIS, a dependable and fully decentralized system that performs cluster-wide off-line deduplication of virtual machines’ primary volumes. DEDIS works on top of any unsophisticated storage backend, centralized or distributed, as long as it exports a basic shared block device interface. Also, DEDIS does not rely on data locality assumptions and incorporates novel optimizations for reducing deduplication overhead and increasing its reliability.
The evaluation of an open-source prototype shows that minimal I/O overhead is achievable even when deduplication and intensive storage I/O are executed simultaneously. Also, our design scales out and allows collocating DEDIS components and virtual machines in the same servers, thus, sparing the need of additional hardware.
The Linear Response Function of an Idealized Atmosphere. Part II: Implications for the Practical Use of the Fluctuation–Dissipation Theorem and the Role of Operator’s Nonnormality
Authors: Hassanzadeh Pedram , Kuang Zhiming 
Published: May 2016

Abstract
A linear response function (LRF) relates the mean response of a nonlinear system to weak external forcings and vice versa. Even for simple models of the general circulation, such as the dry dynamical core, the LRF cannot be calculated from first principles owing to the lack of a complete theory for eddy–mean flow feedbacks. According to the fluctuation–dissipation theorem (FDT), the LRF can be calculated using only the covariance and lag-covariance matrices of the unforced system. However, efforts in calculating the LRFs for GCMs using FDT have produced mixed results, and the reason(s) behind the poor performance of the FDT remain(s) unclear. In Part I of this study, the LRF of an idealized GCM, the dry dynamical core with Held–Suarez physics, is accurately calculated using Green’s functions. In this paper (Part II), the LRF of the same model is computed using FDT, which is found to perform poorly for some of the test cases. The accurate LRF of Part I is used with a linear stochastic equation to show that dimension reduction by projecting the data onto the leading EOFs, which is commonly used for FDT, can alone be a significant source of error. Simplified equations and examples of 2 × 2 matrices are then used to demonstrate that this error arises because of the nonnormality of the operator. These results suggest that errors caused by dimension reduction are a major, if not the main, contributor to the poor performance of the LRF calculated using FDT and that further investigations of dimension-reduction strategies with a focus on nonnormality are needed.
Prospective cohort study of the risk factors for stress fractures in Chinese male infantry recruits
Authors: Zhao Lin , Chang Qi , Huang Tao , Huang Changlin 
Published: May 2016

Objective To determine potential risk factors that could predict stress fractures over an 8-week basic military training in Chinese male infantry recruits. Methods Recruits from three infantry units enrolled in this prospective study. At baseline, demographic data, personal history of stress fractures, mean duration of weekly exercise and smoking history were recorded on questionnaires and blood samples taken for analysis of bone turnover biomarkers and genetic factors. Results Of the 1516 male recruits who volunteered to participate in the study, 1398 recruits provided data for analysis. In total, 189 stress fracture cases were observed (incidence rate: 13.5%) during the 8-week training period. Recruits with stress fractures had a significantly higher incidence of prior fracture history and lower exercise level prior to enrolment compared with those without stress fractures. A significant difference in both allelic frequency and genotypic distribution of the growth differentiation factor 5 ( GDF5) gene rs143383 polymorphism was observed between recruits with and without stress fractures. However, no difference in serum bone turnover biomarkers was detected between groups. Conclusion This prospective, cohort study indicates that fracture history, lower exercise level and GDF5 rs143383 may be predictive risk factors for stress fractures in Chinese male infantry recruits.
Acquired equivalence and related memory processes in migraine without aura
Authors: Öze Attila , Nagy Attila , Benedek György , Bodosi Balázs , Kéri Szabolcs , Pálinkás Éva , Bihari Katalin , Braunitzer Gábor 
Published: May 2016

Introduction Interictal deficits of elementary visuo-cognitive functions are well documented in patients with migraine and are mostly explained in terms of neocortical hyperexcitability. It has been suggested that the basal ganglia and the hippocampi might also be affected in migraine. If so, a deterioration of learning and memory processes related to these structures is expected. Methods A visual learning paradigm thought to be capable of dissociating learning/memory processes mediated by the basal ganglia from processes mediated by the hippocampus (the Rutgers Acquired Equivalence Test) was applied to a group of patients with migraine without aura and to age- and sex-matched controls. Results Patients with migraine showed a significantly poorer performance in both main phases of the test and the deficit in the phase considered to be dependent on the hippocampi was especially marked. Conclusions These results can be interpreted as behavioural support for findings that have suggested the involvement of the basal ganglia and the hippocampi in migraine, but further research is needed to clarify these findings.
Excess cervical cancer screening smears: Any benefit? A retrospective cohort in Alsace, France
Authors: Thiery Alicia , Akladios Cherif , Fender Muriel , Severac François , Baldauf Jean-Jacques 
Published: May 2016

Objectives Although cervical cancer screening guidelines in France recommend a smear test every three years, many physicians order more regular screening. We aimed to assess the benefits or harms of shorter intervals between screenings, both for women and public health. Methods For a retrospective cohort of women aged 25–65 who had two normal smears and at least one additional smear, data were sourced from a regionally organized cervical cancer screening programme in France, with follow-up for nine years. Based on the interval between the second and third smear, two groups were formed; the first comprised overscreened women (interval <24 months), and the second of ‘correctly’ screened women (interval between 24 and 42 months). The primary outcome was cervical intraepithelial neoplasia 2 or worse (CIN2+); secondary outcomes were cervical cancers and CIN1 lesions. Results Among 63,821 women, CIN2+ incidence rate per 10,000 women per year was 14.5 for 40,350 overscreened women, and 11.5 for 23,471 correctly screened women. Age-adjusted relative risk was 1.22[1.02; 1.46]. We found no significant difference for cancer (RR = 1.39; 95%CI = [0.60; 3.61]), but did find additional CIN1 in the overscreened group (RR = 2.09; 95%CI = [1.76; 2.51]). Conclusions A shorter interval between smears has a low benefit for CIN2+ lesion detection, which may not help avoid cancer. The excess number of CIN1 detected by overscreening may cause needless risk and excess costs due to overtreatment.
Association of Palliative Care Consultation With Reducing Inpatient Chemotherapy Use in Elderly Patients With Cancer in Japan: Analysis Using a Nationwide Administrative Database
Authors: Sano Motoko , Fushimi Kiyohide 
Published: May 2016

Background: The administration of chemotherapy at the end of life is considered an aggressive life-prolonging treatment. The use of unnecessarily aggressive therapy in elderly patients at the end of life is an important health-care concern. Objective: To explore the impact of palliative care consultation (PCC) on chemotherapy use in geriatric oncology inpatients in Japan by analyzing data from a national database. Methods: We conducted a multicenter cohort study of patients aged ≥65 years, registered in the Japan National Administrative Healthcare Database, who died with advanced (stage ≥3) lung, stomach, colorectal, liver, or breast cancer while hospitalized between April 2010 and March 2013. The relationship between PCC and chemotherapy use in the last 2 weeks of life was analyzed using χ2 and logistic regression analyses. Results: We included 26 012 patients in this analysis. The mean age was 75.74 ± 6.40 years, 68.1% were men, 81.8% had recurrent cancer, 29.5% had lung cancer, and 29.5% had stomach cancer. Of these, 3134 (12%) received PCC. Among individuals who received PCC, chemotherapy was administered to 46 patients (1.5%) and was not administered to 3088 patients (98.5%). Among those not receiving PCC, chemotherapy was administered to 909 patients (4%) and was not administered to the remaining 21 978 patients (96%; odds ratio [OR], 0.35; 95% confidence interval, 0.26-0.48). The OR of chemotherapy use was higher in men, young–old, and patients with primary cancer. Conclusion: Palliative care consultation was associated with less chemotherapy use in elderly Japanese patients with cancer who died in the hospital setting.
Seismic stratigraphy and tectono-sedimentary framework of the Pliocene to recent Taixinan foreland basin in the northeastern continental margin, South China Sea
Authors: Yin Shaoru , Zhong Guangfa , Guo Yiqun , Wang Liaoliang 
Published: May 2016

The Pliocene to recent Taixinan basin is a unique foreland basin built on the northeastern part of the northern passive margin of the South China Sea (SCS). We have used multichannel seismic profiles tied to well controls from ODP Leg 184 to investigate the tectonic and sedimentary characteristics of the foreland basin. We defined three seismic sequences, dated respectively to the Pliocene (5.33–2.5 Ma), early Quaternary (2.5–1.0 Ma), and late Quaternary (1.0 Ma–present). They represent three stages of evolution of the foreland basin. We have recognized seven types of seismic facies, which are parallel-to-subparallel, progradational, fill-type, divergent mounded, wavy, lenticular, and chaotic facies, and are interpreted as hemipelagic deposits, deltas, submarine canyon fills, levees, sediment waves, submarine fans, and mass transport deposits, respectively. Seismic facies analysis indicates that sedimentation within the foreland basin has been dominated by turbidity currents and the other gravity transport processes. Tectonically, the foreland basin consists of three structural zones: an eastern wedge-top, a central foredeep, and a western forebulge zones. Different from a typical foreland basin, however, the basin extends in the northeast–southwest direction, which is oblique to the north–south-striking Taiwan orogenic zone, but parallel to the northern SCS passive margin, where the basin is hosted, suggesting that the foreland basin is significantly influenced by the development of the passive margin. In addition, the basin displays a distinctive inverted-triangle-shaped downstream-converging sediment dispersal system instead of ideal transverse or longitudinal drainage systems common in a typical foreland basin. We have suggested that the Pliocene to recent Taixinan basin is an atypical foreland basin, which was formed as a flexural response of tectonic loading by the Taiwan orogenic wedge, but strongly affected by its passive continental margin background.
Evaluation of Intensive “4R” Strategies for Decreasing Nitrous Oxide Emissions and Nitrogen Surplus in Rainfed Corn
Authors: Venterea Rodney T. , Coulter Jeffrey A. , Dolan Michael S. 
Published: May 2016

The “4R” approach of using the right rate, right source, right timing, and right placement is an accepted framework for increasing crop N use efficiency. However, modifying only one 4R component does not consistently reduce nitrous oxide (N2O) emissions. Our objective was to determine if N fertilizer applied in three split applications (Sp), by itself or combined with changes in N source and rate, could improve N recovery efficiency (NRE) and N surplus (NS) and decrease N2O emissions. Over two corn (Zea mays L.) growing seasons in Minnesota, N2O emissions ranged from 0.6 to 0.9 kg N ha−1. None of the treatment combinations affected grain yield. Compared with urea applied in a single application at the recommended N rate, Sp by itself did not improve NRE or NS and did not decrease N2O. Combining Sp with urease and nitrification inhibitors and/or a 15% reduction in N rate increased NRE from 57 to >73% and decreased NS by >20 kg N ha−1. The only treatment that decreased N2O (by 20–53%) was Sp combined with inhibitors and reduced N rate. Emissions of N2O were more strongly correlated with NS calculated from grain N uptake (R2 = 0.61) compared with whole‐plant N uptake (r2 = 0.39), possibly because most N losses occurred before grain filling. Optimizing both application timing and N source can allow for a moderate reduction in N rate that does not affect grain yield but decreases N2O. Grain‐based NS may be a more useful indicator of N2O emissions than whole‐plant‐based NS.Core Ideas
Split application by itself did not decrease N2O compared with single application.
Microbial inhibitors did not decrease N2O unless combined with reduced N rate.
Some treatments increased N recovery efficiency but did not reduce N2O.
N2O was more strongly related to N surplus on a grain‐ compared with whole‐plant basis.
Strategies that modify more than one 4R component may be needed to reduce direct N2O.
Global sagittal axis: a step toward full-body assessment of sagittal plane deformity in the human body
Authors: Diebo Bassel G. , Oren Jonathan H. , Challier Vincent , Lafage Renaud , Ferrero Emmanuelle , Liu Shian , Vira Shaleen , Spiegel Matthew Adam , Harris Bradley Yates , Liabaud Barthelemy , Henry Jensen K. , Errico Thomas J. , Schwab Frank J. , Lafage Virginie 
Published: May 2016

OBJECTIVE
Sagittal malalignment requires higher energy expenditure to maintain an erect posture. Because the clinical impact of sagittal alignment is affected by both the severity of the deformity and recruitment of compensatory mechanisms, it is important to investigate new parameters that reflect both disability level and compensatory mechanisms for all patients. This study investigated the clinical relevance of the global sagittal axis (GSA), a novel measure to evaluate the standing axis of the human body.

METHODS
This is a retrospective review of patients who underwent full-body radiographs and completed health-related quality of life (HRQOL) questionnaires: Oswestry Disability Index (ODI), Scoliosis Research Society–22, EuroQol-5D (EQ-5D), and the visual analog scale for back and leg pain. The GSA was defined as the angle formed by a line from the midpoint of the femoral condyles to the center of C-7, and a line from the midpoint between the femoral condyles to the posterior superior corner of the S-1 sacral endplate. After evaluating the correlation of GSA/HRQOL with sagittal parameters, linear regression models were generated to investigate how ODI and GSA related to radiographic parameters (T-1 pelvic angle, pelvic retroversion, knee flexion, and pelvic posterior translation).

RESULTS
One hundred forty-three patients (mean age 44 years) were included. The GSA correlated significantly with all HRQOL (up to r = 0.6 with EQ-5D) and radiographic parameters (up to r = 0.962 with sagittal vertical axis). Regression between ODI and sagittal radiographic parameters identified the GSA as an independent predictor (r = 0.517, r2 = 0.267; p < 0.001). Analysis of standardized coefficients revealed that when controlling for deformity, the GSA increased with a concurrent decrease in pelvic retroversion (−0.837) and increases in knee flexion (+0.287) and pelvic posterior translation (+0.193).

CONCLUSIONS
The GSA is a simple, novel measure to assess the standing axis of the human body in the sagittal plane. The GSA correlated highly with spinopelvic and lower-extremities sagittal parameters and exhibited remarkable correlations with HRQOL, which exceeded other commonly used parameters.
THE VERY MASSIVE STAR CONTENT OF THE NUCLEAR STAR CLUSTERS IN NGC 5253
Authors: Smith L. J. , Crowther P. A. , Calzetti D. , Sidoli F. 
Published: May 2016

ABSTRACT
The blue compact dwarf galaxy NGC 5253 hosts a very young starburst containing twin nuclear star clusters, separated by a projected distance of 5 pc. One cluster (#5) coincides with the peak of the Hα emission and the other (#11) with a massive ultracompact H ii region. A recent analysis of these clusters shows that they have a photometric age of 1 ± 1 Myr, in apparent contradiction with the age of 3–5 Myr inferred from the presence of Wolf-Rayet features in the cluster #5 spectrum. We examine Hubble Space Telescope ultraviolet and Very Large Telescope optical spectroscopy of #5 and show that the stellar features arise from very massive stars (VMSs), with masses greater than 100 M
⊙, at an age of 1–2 Myr. We further show that the very high ionizing flux from the nuclear clusters can only be explained if VMSs are present. We investigate the origin of the observed nitrogen enrichment in the circumcluster ionized gas and find that the excess N can be produced by massive rotating stars within the first 1 Myr. We find similarities between the NGC 5253 cluster spectrum and those of metal-poor, high-redshift galaxies. We discuss the presence of VMSs in young, star-forming galaxies at high redshift; these should be detected in rest-frame UV spectra to be obtained with the James Webb Space Telescope. We emphasize that population synthesis models with upper mass cutoffs greater than 100 M
⊙ are crucial for future studies of young massive star clusters at all redshifts.
SLIPPING MAGNETIC RECONNECTION, CHROMOSPHERIC EVAPORATION, IMPLOSION, AND PRECURSORS IN THE 2014 SEPTEMBER 10 X1.6-CLASS SOLAR FLARE
Authors: Dudík Jaroslav , Polito Vanessa , Janvier Miho , Mulay Sargam M. , Karlický Marian , Aulanier Guillaume , Zanna Giulio Del , Dzifčáková Elena , Mason Helen E. , Schmieder Brigitte 
Published: May 2016

ABSTRACT
We investigate the occurrence of slipping magnetic reconnection, chromospheric evaporation, and coronal loop dynamics in the 2014 September 10 X-class flare. Slipping reconnection is found to be present throughout the flare from its early phase. Flare loops are seen to slip in opposite directions toward both ends of the ribbons. Velocities of 20–40 km s−1 are found within time windows where the slipping is well resolved. The warm coronal loops exhibit expanding and contracting motions that are interpreted as displacements due to the growing flux rope that subsequently erupts. This flux rope existed and erupted before the onset of apparent coronal implosion. This indicates that the energy release proceeds by slipping reconnection and not via coronal implosion. The slipping reconnection leads to changes in the geometry of the observed structures at the Interface Region Imaging Spectrograph slit position, from flare loop top to the footpoints in the ribbons. This results in variations of the observed velocities of chromospheric evaporation in the early flare phase. Finally, it is found that the precursor signatures, including localized EUV brightenings as well as nonthermal X-ray emission, are signatures of the flare itself, progressing from the early phase toward the impulsive phase, with the tether-cutting being provided by the slipping reconnection. The dynamics of both the flare and outlying coronal loops is found to be consistent with the predictions of the standard solar flare model in three dimensions.
CHANDRA X-RAY AND HUBBLE SPACE TELESCOPE IMAGING OF OPTICALLY SELECTED KILOPARSEC-SCALE BINARY ACTIVE GALACTIC NUCLEI. II. HOST GALAXY MORPHOLOGY AND AGN ACTIVITY*
Authors: Shangguan Jinyi , Liu Xin , Ho Luis C. , Shen Yue , Peng Chien Y. , Greene Jenny E. , Strauss Michael A. 
Published: May 2016

ABSTRACT
Binary active galactic nuclei (AGNs) provide clues to how gas-rich mergers trigger and fuel AGNs and how supermassive black hole (SMBH) pairs evolve in a gas-rich environment. While significant effort has been invested in their identification, the detailed properties of binary AGNs and their host galaxies are still poorly constrained. In a companion paper, we examined the nature of ionizing sources in the double nuclei of four kiloparsec-scale binary AGNs with redshifts between 0.1 and 0.2. Here, we present their host galaxy morphology based on F336W (U-band) and F105W (Y-band) images taken by the Wide Field Camera 3 on board the Hubble Space Telescope. Our targets have double-peaked narrow emission lines and were confirmed to host binary AGNs with follow-up observations. We find that kiloparsec-scale binary AGNs occur in galaxy mergers with diverse morphological types. There are three major mergers with intermediate morphologies and a minor merger with a dominant disk component. We estimate the masses of the SMBHs from their host bulge stellar masses and obtain Eddington ratios for each AGN. Compared with a representative control sample drawn at the same redshift and stellar mass, the AGN luminosities and Eddington ratios of our binary AGNs are similar to those of single AGNs. The U − Y color maps indicate that clumpy star-forming regions could significantly affect the X-ray detection of binary AGNs, e.g., the hardness ratio. Considering the weak X-ray emission in AGNs triggered in merger systems, we suggest that samples of X-ray-selected AGNs may be biased against gas-rich mergers.