bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing Process Safety Events: An approach proven by sustainable results
Authors: Champion John , Van Geffen Sheila , Borrousch Lynnette 
Published: October 2017

The Dow Chemical Company has significantly reduced the number of Tier 1 Process Safety events from 69 in 2008 to an average of 10 in 2013–2015. This paper will share some of the key elements that have led to this successful and sustainable reduction in incidents. The structure of the paper is focused around the concept of “Effective Process Safety Programs” published by Klein and Vaughen, Process Safety: Key Concepts and Practical Applications, CRC Press, 2017.In this paper, we will provide details on Dow's Operational Discipline systems that enable success on a day‐to‐day basis. These systems include Procedure Use Culture, Process Safety Training programs, and Process Safety Collaboration Networks. We will also describe our Process Safety Management Systems that enable long‐term success including Dow's Loss Prevention Principles (LPP), use of Process Hazards Analysis (PHA), Layer of Protection Analysis (LOPA) and other tools to manage risk, and Dow's Mechanical Integrity program. The success is built on a strong foundation of Safety Culture and Leadership. This paper will illustrate how Dow is structured to support the Process Safety efforts and examples will be shared about how leadership at all levels of the organization is practiced and demonstrated. © 2017 American Institute of Chemical Engineers Process Saf Prog 36: 326–337, 2017
The effects of higher orders of perturbation theory on the correlation energy of atoms and bonds in molecules
Authors: Vincent Mark A. , Silva Arnaldo F. , McDonagh James L. , Popelier Paul L. A. 
Published: October 2017

AbstractWe examine, for the first time, the effects of higher orders of Møller–Plesset perturbation theory on the individual atoms within a molecule and the bonds between them, via the topological energy partitioning method of interacting quantum atoms. In real terms (i.e., not by absolute value) MP3 decreases the correlation energy of a bond, and MP4SDQ also decreases the energy of the atoms at either end of the bond. In addition, we investigated long‐range through‐space dispersive effects on a H2oligomer. Overall, MP3 is the largest correction to the correlation energy, and most of that energy is allocated to chemical bonds, reducing their values in actual terms. The MP4SDQ bond correlation correction, despite being relatively small, tends to have two effects: (i) for small or negative correlation energies MP4SDQ tends to decrease the bond correlation values even more, and (ii) for large (positive) bond correlation energies MP4SDQ tends to restore the bond correlation energies from the MP3 back toward the MP2 values. Furthermore, each individual part of a molecule or complex (atom or bond) has a specific convergence pattern for the MPnseries: through‐space interactions converge at MP2 but bonds converge at MP3 level. The atomic correlation energy appears to head toward convergence at the MP4 level.
Insight into the π‐hole···π‐electrons tetrel bonds between F2ZO (Z = C, Si, Ge) and unsaturated hydrocarbons
Authors: Shen Shaojie , Zeng Yanli , Li Xiaoyan , Meng Lingpeng , Zhang Xueying 
Published: October 2017

AbstractThe intermolecular π‐hole···π‐electrons interactions between F2ZO (Z = C, Si, Ge) molecules and unsaturated hydrocarbons including acetylene, ethylene, 1,3‐butadiene and benzene were constructed to reveal the differences of tetrel bonds forming by carbon and heavier tetrel atoms. The ab initio computation in association with topological analysis of electron density, natural bond orbital, and energy decomposition analysis demonstrate that the strength of Si···π and Ge···π tetrel bonds is much stronger than that of C···π tetrel bonds. The Si···π and Ge···π tetrel bonds exhibit covalent or partially covalent interaction nature, while the weak C···π tetrel bonds display the hallmarks of noncovalent interaction, the electrostatic interaction is the primary influencing factor. The Si···π and Ge···π interactions are determined by both the σ‐ and π‐electron densities, while the C···π interactions are dominated mainly by the π‐electron densities. The π‐hole···π‐electrons tetrel bonds are dominated by electrostatic interaction, and polarization has a comparable contribution in the Si···π and Ge···π tetrel bonds.
Microparticles Carrying Peroxisome Proliferator-Activated Receptor Alpha Restore the Reduced Differentiation and Functionality of Bone Marrow-Derived Cells Induced by High-Fat Diet
Authors: Vergori Luisa , Lauret Emilie , Soleti Raffaella , Andriantsitohaina Ramaroson , Carmen Martinez M. 
Published: October 2017

Abstract
Metabolic pathologies such as diabetes and obesity are associated with decreased level of circulating and bone marrow (BM)-derived endothelial progenitor cells (EPCs). It is known that activation of peroxisome proliferator-activated receptor alpha (PPARα) may stimulate cell differentiation. In addition, microparticles (MPs), small membrane vesicles produced by activated and apoptotic cells, are able to reprogram EPCs. Here, we evaluated the role of MPs carrying PPARα on both phenotype and function of progenitor cells from mice fed with a high-fat diet (HFD). HFD reduced circulating EPCs and, after 7 days of culture, BM-derived EPCs and monocytic progenitor cells from HFD-fed mice displayed impaired differentiation. At the same time, we show that MPs bearing PPARα, MPsPPARα+/+, increased the differentiation of EPCs and monocytic progenitors from HFD-fed mice, whereas MPs taken from PPARα knockout mice (MPsPPARα−/−) had no effect on the differentiation of all types of progenitor cells. Furthermore, MPsPPARα+/+ increased the ability of progenitor cells to promote in vivo angiogenesis in mice fed with HFD. The in vitro and in vivo effects of MPsPPARα+/+ were abolished in presence of MK886, a specific inhibitor of PPARα. Collectively, these data highlight the ability of MPs carrying PPARα to restore the failed differentiation and functionality of BM-derived cells induced by HFD.
Effect of Autologous Cord Blood Infusion on Motor Function and Brain Connectivity in Young Children with Cerebral Palsy: A Randomized, Placebo-Controlled Trial
Authors: Sun Jessica M. , Song Allen W. , Case Laura E. , Mikati Mohamad A. , Gustafson Kathryn E. , Simmons Ryan , Goldstein Ricki , Petry Jodi , McLaughlin Colleen , Waters-Pick Barbara , Chen Lyon W. , Wease Stephen , Blackwell Beth , Worley Gordon , Troy Jesse , Kurtzberg Joanne 
Published: October 2017

Abstract
Cerebral palsy (CP) is a condition affecting young children that causes lifelong disabilities. Umbilical cord blood cells improve motor function in experimental systems via paracrine signaling. After demonstrating safety, we conducted a phase II trial of autologous cord blood (ACB) infusion in children with CP to test whether ACB could improve function (ClinicalTrials.gov, NCT01147653; IND 14360). In this double-blind, placebo-controlled, crossover study of a single intravenous infusion of 1–5 × 107 total nucleated cells per kilogram of ACB, children ages 1 to 6 years with CP were randomly assigned to receive ACB or placebo at baseline, followed by the alternate infusion 1 year later. Motor function and magnetic resonance imaging brain connectivity studies were performed at baseline, 1, and 2 years post-treatment. The primary endpoint was change in motor function 1 year after baseline infusion. Additional analyses were performed at 2 years. Sixty-three children (median age 2.1 years) were randomized to treatment (n = 32) or placebo (n = 31) at baseline. Although there was no difference in mean change in Gross Motor Function Measure-66 (GMFM-66) scores at 1 year between placebo and treated groups, a dosing effect was identified. In an analysis 1 year post-ACB treatment, those who received doses ≥2 × 107/kg demonstrated significantly greater increases in GMFM-66 scores above those predicted by age and severity, as well as in Peabody Developmental Motor Scales-2 Gross Motor Quotient scores and normalized brain connectivity. Results of this study suggest that appropriately dosed ACB infusion improves brain connectivity and gross motor function in young children with CP.
Concise Review: Biomimetic Functionalization of Biomaterials to Stimulate the Endogenous Healing Process of Cartilage and Bone Tissue
Authors: Taraballi Francesca , Bauza Guillermo , McCulloch Patrick , Harris Josh , Tasciotti Ennio 
Published: October 2017

Abstract
Musculoskeletal reconstruction is an ongoing challenge for surgeons as it is required for one out of five patients undergoing surgery. In the past three decades, through the close collaboration between clinicians and basic scientists, several regenerative strategies have been proposed. These have emerged from interdisciplinary approaches that bridge tissue engineering with material science, physiology, and cell biology. The paradigm behind tissue engineering is to achieve regeneration and functional recovery using stem cells, bioactive molecules, or supporting materials. Although plenty of preclinical solutions for bone and cartilage have been presented, only a few platforms have been able to move from the bench to the bedside. In this review, we highlight the limitations of musculoskeletal regeneration and summarize the most relevant acellular tissue engineering approaches. We focus on the strategies that could be most effectively translate in clinical practice and reflect on contemporary and cutting-edge regenerative strategies in surgery.
Unusual Rhesus Antibodies as a Cause for Fetal Isoimmunisation
Authors: Raheja Aastha , Agarwal Krishna 
Published: October 2017

AbstractHemolytic disease of the newborn due to Rh isoimmunisation in a Rhesus D (Rh-D) negative mother with an Rh-D positive fetus is a well recognised entity. Although antibody to Rh-D antigen (anti-D antibody) was once the major cause of hemolytic disease of the fetus and newborn (HDFN), widespread adoption of antenatal and postnatal prophylactic anti-D immunoglobulin administration has resulted in a marked decrease in the prevalence of allo-immunisation due to the Rh-D antigen during pregnancy. However, at the same time, the maternal allo-immunisation to other red cell Rhesus antigens became more evident as a cause for HDFN, since no prophylactic immunoglobulins are available to prevent the formation of these antibodies. The authors report a case of a pregnant woman with AB negative blood group and positive indirect Coombs test (ICT) with rising middle cerebral artery peak systolic velocity (MCA-PSV) on follow up visits. Fetus required intrauterine transfusion. Fetal cord blood sampling revealed the fetus to be B negative and the direct Coombs test (DCT) was positive. On further testing, maternal serum was found to be positive for anti-D, anti-C and anti-G antibodies. Postnatally, the baby required double volume exchange transfusion. The authors highlight the importance of irregular antibody screening for women with obstetric history suggestive of HDNF. This could help in diagnosis and successful treatment of the affected fetus.
A Population-Based Epidemiologic Study of Female Sexual Dysfunction Risk in Mainland China: Prevalence and Predictors
Authors: Zhang Chunni , Tong Jiali , Zhu Lan , Zhang Lei , Xu Tao , Lang Jinghe , Xie Yu 
Published: October 2017

Abstract

Background
Epidemiologic data on female sexual dysfunction in China are sparse.

Aim
To assess the prevalence of risk of female sexual dysfunction in mainland China and its regional and sociodemographic variations and physiologic, pathologic, and behavioral risk factors.

Methods
A survey of the general female population was conducted in mainland China from February 2014 through January 2016. Women were randomly selected using multistage, stratified, cluster sampling. The prevalence rate of sexual dysfunction, as measured by the Female Sexual Function Index and a score lower than 23.45 as the cutoff threshold, was determined. Multivariate logistical regression models were used to examine the effects of sociodemographic, physiologic, pathologic, and behavioral factors on women’s risk of experiencing sexual dysfunction and domain-specific sexual problems.

Outcomes
The questionnaire on sexual dysfunction was completed by 25,446 women 20 to 70 years old.

Results
The prevalence of sexual dysfunction in women 20 to 70 years old in mainland China was estimated at 29.7% (99% CI = 28.9–30.4), with large regional variations. The prevalence rates of potential domain-specific sexual problems were 21.6% (99% CI = 20.9–22.2) for low desire, 21.5 (99% CI = 20.8–22.2) for arousal disorder, 18.9% (99% CI = 18.3–19.6) for lubrication disorder, 27.9% (99% CI = 27.2–28.7) for orgasm disorder, and 14.1% (99% CI = 13.6–14.7) for sexual pain. Higher educational attainment and urban residency were associated with a decreased risk of sexual dysfunction. Women of ethnic minorities (or non-Han ethnicity) had fewer reports of sexual dysfunction than women of Han ethnicity (odds ratio = 0.67, 99% CI = 0.47–0.97). Diabetes, cancers, pelvic inflammatory disease, and pelvic organ prolapse significantly increased the reports of sexual dysfunction.

Clinical Translation
This survey provided the prevalence and risk factors of female sexual dysfunction in China, information that could be useful for potential prevention and clinical treatment.

Strengths and Limitations
This is the first large-scale, nationally based epidemiologic study of female sexual dysfunction in mainland China. The limitations of the study design included an overpowered study caused by the large sample, the under-representation of younger and unmarried women, and no information on the women’s partners, their values and knowledge, and detailed medical conditions.

Conclusions
The prevalence rate of female sexual dysfunction in mainland China was modest overall, although variations existed across regions and social groups.
Sexual Dysfunction in Primary Care: An Exploratory Descriptive Analysis of Medical Record Diagnoses
Authors: Heiden-Rootes Katie M. , Salas Joanne , Gebauer Sarah , Witthaus Matthew , Scherrer Jeffrey , McDaniel Kristin , Carver Dasha 
Published: October 2017

AbstractBackgroundThe prevalence of sexual dysfunction (SDx) diagnoses in primary care settings is not well known, which is a concern because of the high prevalence of comorbid chronic health conditions in patients diagnosed with SDx.AimTo explore the relation of SDx diagnosis, chronic health conditions, and prescription medications commonly associated with SDx for men and women in primary care using medical records diagnoses.MethodsExploratory descriptive analyses were used to interpret secondary data from a primary care patient database. The database included patient data from 3 family and internal medicine clinics in the St Louis metropolitan area from July 1, 2008 to June 30, 2015. Analysis included key demographic variables, chronic illness, and health conditions of hypertension, pain, prostate disorder, menopause, substance abuse, depression, anxiety, and associated medications. Analysis of the database yielded 30,627 adult patients (men: n = 12,097, mean age = 46.8 years, 65.6% white race; women: n = 18,530, mean age = 46.6 years, 59.2% white race) with significant comorbid associations between SDx and other chronic illness, health conditions, and medication prescription.ResultsDepression, anxiety, pain, hypertension, diabetes, and psychotropic medication use were significantly associated with SDx for men and women. Examination of specific SDx diagnoses showed erectile dysfunction to be significantly associated with all tested variables for men. For women, pain-related SDx diagnoses were associated more with chronic illness, health conditions, and medication use than were psychosexual SDx diagnoses (eg, orgasm), except for menopause. Prevalence varied by sex, with a higher prevalence rate of any SDx for men (13.5%) than for women (1.0%), although sex comparisons were not part of the analytics.Clinical TranslationThis study suggests the diagnosis of SDx is closely associated with other common chronic illness and health conditions and could go underdiagnosed in women in primary care.Strengths and LimitationsThe cross-sectional nature of the study limits the ability to draw causal conclusions related to the nature of the associated conditions with SDx diagnoses. The generalizability of the findings also might be limited given the specific demographic or health makeup of the St Louis area where the study was conducted.ConclusionThe high comorbidity of SDx with mental health, chronic pain and illnesses, and medication use adds to the growing evidence that sexual health and functioning are essential components of overall well-being and holistic care for men and women.
Psychobiological Correlates of Vaginismus: An Exploratory Analysis
Authors: Maseroli Elisa , Scavello Irene , Cipriani Sarah , Palma Manuela , Fambrini Massimiliano , Corona Giovanni , Mannucci Edoardo , Maggi Mario , Vignozzi Linda 
Published: October 2017

Abstract

Background
Evidence concerning the determinants of vaginismus (V), in particular medical conditions, is inconclusive.

Aim
To investigate, in a cohort of subjects consulting for female sexual dysfunction, whether there is a difference in medical and psychosocial parameters between women with V and women with other sexual complaints.

Methods
A series of 255 women attending our clinic for female sexual dysfunction was consecutively recruited. V was diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. Lifelong and acquired V cases were included.

Outcomes
Patients underwent a structured interview and physical, gynecologic, laboratory, and clitoral ultrasound examinations; they completed the Female Sexual Function Index (FSFI), the Middlesex Hospital Questionnaire, the Female Sexual Distress Scale–Revised (FSDS), and the Body Uneasiness Test.

Results
V was diagnosed in 20 patients (7.8%). Women with V were significantly younger than the rest of the sample (P &lt; .05). No differences were found for traditional risk factors such as a history of sexual abuse, relational parameters, or gynecologic diseases or for newly investigated parameters (ie, neurologic, hormonal, and metabolic alterations). Women with V showed significantly higher histrionic-hysterical symptoms and traits (as detected by MHQ-H score; P &lt; .05) compared with subjects with other sexual complaints. When the scores of all MHQ subscales were simultaneously introduced in a logistic model, the association between V and MHQ-H score was confirmed (P = .013). Women with V also showed higher FSFI pain and FSDS total scores, even after adjusting for age (P &lt; .05). In an age-adjusted model, FSDS total score increased as a function of the years of duration of V (P = .032) but not as a function of its severity. All observations were confirmed in a case-control study (ratio = 1:3).

Clinical Implications
Our data demonstrate that some novel contributors of V should be investigated, namely histrionic-hysterical traits. This psychological comorbidity could offer valuable insights for intervention and managing complications.

Strengths and Limitations
This is the first study to assess the role of many metabolic and hormonal parameters as potential determinants of V. The main limitation is its exploratory and cross-sectional nature; our data need to be confirmed in larger, more systematic analyses.

Conclusion
V was associated with histrionic-hysterical traits, FSFI pain domain, and sex-related distress. A history of abuse, relational parameters, gynecologic diseases, and hormonal and metabolic alterations do not seem to play a role in the development of V.
The Mesolithic-Neolithic Transition and the Chronology of the “elm decline”: A Case Study from Yorkshire and Humberside, United Kingdom
Authors: Griffiths Seren , Gearey Benjamin R 
Published: October 2017

ABSTRACTThe Neolithic in Britain saw the first appearance of domestic plant and animal resources, pottery, polished stone axes, monuments, and new house structures. With the introduction of domesticates and associated subsistence strategies, the Neolithic represents a significant change in human–environment interaction. Other changes have been observed in the palynological record of Britain in the early fourth millennium cal BC, including the elm decline, and archaeologists and paleobotanists have long discussed the degree of human involvement in this. This paper presents the first Bayesian statistical analysis of the elm decline using the case study of the east of Yorkshire and Humberside and key sites in west Yorkshire, and evidence for the last hunter-gatherer Mesolithic material culture and the first Neolithic material culture record. This region is critical because it is the only area of Britain and Ireland where we have robust and accurate published estimates for the timing of the latest Mesolithic activity and timing for the earliest Neolithic activity. Unpacking this perceived chronological correlation between the elm decline and the start of the Neolithic is critical to understanding the scale of human–environment modification at this time, and the nature of the first Neolithic societies in Britain.
ASH1L histone methyltransferase regulates the handoff between damage recognition factors in global-genome nucleotide excision repair
Authors: Balbo Pogliano Chiara , Gatti Marco , Rüthemann Peter , Garajovà Zuzana , Penengo Lorenza , Naegeli Hanspeter 
Published: October 2017

AbstractGlobal-genome nucleotide excision repair (GG-NER) prevents ultraviolet (UV) light-induced skin cancer by removing mutagenic cyclobutane pyrimidine dimers (CPDs). These lesions are formed abundantly on DNA wrapped around histone octamers in nucleosomes, but a specialized damage sensor known as DDB2 ensures that they are accessed by the XPC initiator of GG-NER activity. We report that DDB2 promotes CPD excision by recruiting the histone methyltransferase ASH1L, which methylates lysine 4 of histone H3. In turn, methylated H3 facilitates the docking of the XPC complex to nucleosomal histone octamers. Consequently, DDB2, ASH1L and XPC proteins co-localize transiently on histone H3-methylated nucleosomes of UV-exposed cells. In the absence of ASH1L, the chromatin binding of XPC is impaired and its ability to recruit downstream GG-NER effectors diminished. Also, ASH1L depletion suppresses CPD excision and confers UV hypersensitivity. These findings show that ASH1L configures chromatin for the effective handoff between damage recognition factors during GG-NER activity.
Periodic squeezing in a polariton Josephson junction
Authors: Adiyatullin Albert F. , Anderson Mitchell D. , Flayac Hugo , Portella-Oberli Marcia T. , Jabeen Fauzia , Ouellet-Plamondon Claudéric , Sallen Gregory C. , Deveaud Benoit 
Published: October 2017

AbstractThe use of a Kerr nonlinearity to generate squeezed light is a well-known way to surpass the quantum noise limit along a given field quadrature. Nevertheless, in the most common regime of weak nonlinearity, a single Kerr resonator is unable to provide the proper interrelation between the field amplitude and squeezing required to induce a sizable deviation from Poissonian statistics. We demonstrate experimentally that weakly coupled bosonic modes allow exploration of the interplay between squeezing and displacement, which can give rise to strong deviations from the Poissonian statistics. In particular, we report on the periodic bunching in a Josephson junction formed by two coupled exciton-polariton modes. Quantum modeling traces the bunching back to the presence of quadrature squeezing. Our results, linking the light statistics to squeezing, are a precursor to the study of nonclassical features in semiconductor microcavities and other weakly nonlinear bosonic systems.