bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gonadotropin-Releasing Hormone Receptor Antagonist Mono- and Combination Therapy With Estradiol/Norethindrone Acetate Add-Back: Pharmacodynamics and Safety of OBE2109
Authors: Pohl Oliver , Marchand Line , Fawkes Neil , Gotteland Jean-Pierre , Loumaye Ernest 
Published: December 2017

Abstract

Context
OBE2109 is a potent, oral gonadotropin-releasing hormone receptor antagonist being developed for the treatment of sex-hormone–dependent diseases in women.

Objective
We assessed the pharmacodynamics and safety of OBE2109 alone and combined with estradiol (E2)/norethindrone acetate (NETA) add-back therapy on E2 levels and vaginal bleeding.

Design, Setting, and Participants
This was a single-center, open-label, randomized, parallel-group study in 76 healthy premenopausal women.

Interventions
Women were randomly assigned to take the following doses (in milligrams) once daily for 6 weeks: OBE2109, 100 or 200; or OBE2109/E2/NETA, 100/0.5/0.1, or 100/1.0/0.5, or 200/1.0/0.5.

Main Outcome Measures
E2 concentrations, bleeding pattern, exploratory bone metabolism biomarkers, and adverse events.

Results
OBE2109 100 mg and 200 mg alone reduced E2 levels to reach median levels of 19.5 and 3.2 pg/mL, respectively, at week 4. Median E2 levels after combined OBE2109/add-back therapy ranged between 25 and 40 pg/mL. OBE2109 100 mg or 200 mg alone induced amenorrhea. By day 15, &gt;85% of women had no vaginal bleeding during the last 4 weeks of treatment. Add-back therapy partially impaired bleeding control: The highest amenorrhea rate (53%) was observed with OBE2109 100 mg/1.0 mg/0.5 mg. The addition of E2/NETA, particularly at 1 mg/0.5 mg, mitigated the increase of two bone markers induced by OBE2109 200 mg.

Conclusion
OBE2109 promptly lowered E2 levels. Add-back therapy may be required to prevent adverse effects on bone in women treated with the 200-mg dose (at 100 mg in some women). These results provide a basis for OBE2109 regimen selection to treat sex-hormone–dependent diseases.
Διαλογικές πρακτικές προς μια συμμετοχική προσχολική εκπαίδευση: Ένα μοντέλο υποστήριξης των εκπαιδευτικών
Authors: Likomitrou Sonia , Avgitidou Sofia 
Published: December 2017

Η παρούσα έρευνα έχει ως αντικείμενο τη μελέτη των διαδικασιών και των αποτελεσμάτων μιας συνεργατικής έρευνας-δράσης, που υποστήριξε τους εκπαιδευτικούς να βελτιώσουν/αλλάξουν τις διαλογικές πρακτικές τους κατά τη μαθησιακή διαδικασία. Σκοπός της έρευνας ήταν η διερεύνηση των διαλογικών πεποιθήσεων και πρακτικών των εκπαιδευτικών στην προσχολική εκπαίδευση καθώς και η διερεύνηση της αποτελεσματικότητας των διαδικασιών υποστήριξής τους, με σκοπό τη βελτίωση των εκπαιδευτικών διαλογικών πρακτικών στη μαθησιακή διαδικασία. Η συγκεκριμένη έρευνα αξιοποιεί δεδομένα από μια συνεργατική έρευνα-δράση, με οκτώ νηπιαγωγούς, που διήρκεσε ένα χρόνο και συμπεριέλαβε ατομικές συνεντεύξεις με τις νηπιαγωγούς, ομαδικές συναντήσεις και μαγνητοφωνημένες καταγραφές των διαλογικών πρακτικών τους. Τα αποτελέσματα της μελέτης έδειξαν ότι παρά τη διαφοροποίηση των πεποιθήσεων των νηπιαγωγών σχετικά με το νόημα και τη διαδικασία του διαλόγου, οι διαλογικές πρακτικές τους ήταν παρόμοιες, αναδεικνύοντας τη λεκτική κυριαρχία του εκπαιδευτικού μέσα στην τάξη και τον παθητικό ρόλο που έδιναν στα παιδιά, περιορίζοντας μ’ αυτόν τον τρόπο τις ευκαιρίες για συμμετοχή των παιδιών σ’ έναν δημοκρατικό διάλογο. Παρόλα αυτά, τόσο οι πεποιθήσεις όσο και οι διαλογικές πρακτικές των νηπιαγωγών που συμμετείχαν στην έρευνα-δράση τροποποιήθηκαν μέσω της υποστήριξής τους σε θεωρητικό, ερευνητικό και στοχαστικό επίπεδο. Τα αποτελέσματα της παρούσας έρευνας συζητιούνται στο πλαίσιο της επαγγελματικής μάθησης των εκπαιδευτικών με σκοπό τη βελτίωση του εκπαιδευτικού έργου μέσω της επανατοποθέτησής τους σχετικά με τις πεποιθήσεις και τις πρακτικές τους για τη διαλογική διαδικασία και τη μάθηση.
Coefficients for Quantifying Subsurface Drainage Rates
Authors: Skaggs R. Wayne 
Published: December 2017

Abstract. It is proposed that technical papers on drainage research studies and engineered design projects should report standard coefficients or parameters that characterize the hydraulics of the system. The following coefficients define key subsurface drainage rates that can be used to quantify and compare the hydraulics of drainage systems across sites, soils and geographic locations. (1) The steady subsurface drainage rate (cm/d) corresponding to a saturated profile with a ponded surface. This subsurface drainage rate defines the length of time that water remains ponded on the soil surface following large rainfall events. It is proposed that this rate be called the Kirkham Coefficient (KC) in honor of Professor Don Kirkham who derived analytical solutions for saturated drained profiles for most soil and boundary conditions of interest. (2) Drainage intensity (DI), which represents the drainage rate (cm/d) when the water table midway between parallel drains is coincident with the surface. The DI can be estimated by the Hooghoudt equation and is dependent on the effective saturated hydraulic conductivity of the profile, drain depth, spacing, and depth of the soil profile or restrictive layer. (3) The drainage coefficient (DC), which quantifies the hydraulic capacity of the system. This value is the rate (cm/d) that the outlet works can remove water from the site. It is dependent on the size, slope, and hydraulic roughness of the laterals, submains, mains, and, in cases where pumped outlets are used, the pumping capacity. Routine inclusion of these three coefficients in the documentation of research and design projects would facilitate comparison of results from different soils and drainage systems, and generally, the meta-analysis of data pertaining to drainage studies. Keywords: Drainage, Drainage intensity, Drainage coefficient, Drainage nomenclature, Kirkham Coefficient.
Farmer adaptation strategy in paddy fields affected by climate variability in monsoon regions
Authors: APRIYANA YAYAN , SARVINA YELI , DEWI ELSA RAKHMI , PRAMUDIA ARIS 
Published: December 2017

Abstract. Apriyana Y, Sarvina Y, Dewi ER, Pramudia A. 2017. Farmer adaptation strategy in paddy field affected by climate variability in monsoon regions. Asian J Agric 1: 9-16. One of the strategies to minimize the impacts of climate variability and climate anomalies on paddy fields in monsoon regions is the adaptation of agriculture cultivation. It is important to minimize the impact of these two phenomena to reduce economic loss, particularly for food security in Indonesia. The objectives of this study are: (i) to identify onset and cropping pattern in irrigated land, rainfed and dry land in affected areas due to climate anomalies, (ii) to collect information on carrying capacity water resources and adaptation practices applied by farmers and, (iii) to identify strategies for farmers on irrigated land, rainfed and dry land in the region affected by climate variability. The desk work analysis and field survey were conducted in Serang district, Banten Province, Subang district, West Java Province and Pati district, Central Jawa Province, Indonesia. The study was undertaken in three cluster activities i.e. (i) correlation analysis of climate anomalies and rainfall, (ii) field survey and, (iii) analysis of onset planting season, cropping pattern, water availability, the best planting time and irrigation schedule. The results showed that the farmers in affected areas due to climate variability could adapt by shifting the onset of planting season. Farmers in irrigated lands changed their onset around 2-4 ten-days period to October II - December II. Furthermore, in rainfed areas, the onset around 4-6 ten-days period was shifted to November I - January III. For dryland their onset around 6-8 ten-days period was moved to November II - February I. The cropping pattern rice-rice-palawija/fallow was applied on irrigated land. Furthermore, the pattern of rice-rice/palawija/fallow-fallow was carried out in rainfed. Finally, the pattern of palawija-palawija/fallow-dormant was performed on the dry land. Adaptation programs dealing with climate variability in Serang and Pati districts varied more than in Subang district. In Serang and Pati, during the first planting season, farmers applied irrigation from approximately 20%-30% water pump from the river and during second planting season, farmers in Pati district used water from a well-pump, as well as in Serang that can reach 100% of the application.
Fecundity performance of nilem (Osteochilus vittatus) from Cianjur, Tasikmalaya and Kuningan Districts, West Java, Indonesia
Authors: ROSTIKA RITA , ANDRIANI YULI , JUNIANTO JUNIANTO 
Published: December 2017

Abstract. Rostika R, Andriani Y, Junianto. 2017. Fecundity performance of nilem (Osteochilus vittatus) from Cianjur, Tasikmalaya and Kuningan Districts, West Java, Indonesia. Asian J Agric 1: 17-21. The aim of this study was to know the reproduction aspects of nilem (Osteochilus vittatus Valenciennes, 1842; syn. Osteochilus hasseltii Valenciennes, 1842). The study was conducted from October 2015 to March 2016. This research included elements of body length, weight, gonad maturity level (GML) and fecundity. There were 27 samples collected from farming activities in Cianjur, Tasikmalaya and Kuningan West Java, Indonesia. The parameters observed were the correlation between weight and fecundity, correlation between body length and fecundity and GML. The method used was explorative approach and the data were analyzed by descriptive approach. The results showed that the correlation between weight and fecundity in Cianjur District was y= e0,024x, while the body length and fecundity was y=e0,413x. In Tasikmalaya District was y= e0,0728x, while the body length and fecundity was y=e0,4903x. In Kuningan District was y= e0,2902x, while the correlation between the length of the fish and fecundity was y=e0,6859x. The dominant gonad maturity level of O. vittatus in Cianjur was GML IV (50%), Tasikmalaya was GMLVI (100%), and Kuningan was GML V (55,56%) respectively. The relationship between length and body weight of Osteochillus vittatus from Cianjur, Tasikmalaya and Kuningan District were W=0,03L2,95, W = 0.04L2.89 and W = 0.04L2.79 respectively. The implication of this research was to understand the proper size of O. vittatus that can be harvested that have an optimum egg volume.
Degradation level of mangrove forest and its reduction strategy in Tabongo Village, Boalemo District, Gorontalo Province, Indonesia
Authors: KATILI ABUBAKAR SIDIK , IBRAHIM MUSTAMIN , ZAKARIA ZULIANTO 
Published: December 2017

Katili AS, Ibrahim M, Zakaria Z. 2017. Degradation level of mangrove forest and its reduction strategy in Tabongo Village, Boalemo District, Gorontalo Province, Indonesia. Asian J For 1: 18-22. This research aimed to assess the degradation level of mangrove forest and to develop strategy to reduce the degradation level. The overall research duration was 1 year, focusing on identification of mangrove forests degradation level, exploration of mangrove vegetation structure and preparation for mangrove degradation reduction strategy. The research was located in Tabongo Village, Dulupi Sub-district, Boalemo District, Gorontalo Province. The method used in the research was explorative survey, while the data analysis was done with quantitative descriptive analysis. The collecting method used was point quarter centered meter (PQCM) method. The degradation level of mangrove forest was analyzed by standard criteria of mangrove destruction according to Ministerial Decree of State Minister for The Environment (Kepmen. LH) No. 201 in 2004. Results showed that there are 4 species of mangrove plants in Tabongo Village, Dulupi Sub-district namely Rhizophora apiculata Blume, Rhizophora mucronata Lamk., Ceriops tagal (Perr) C.B.Rob, and Bruguiera which included in the Rhizophoraceae family. Rhizophora apiculata had the highest IVI value at the stage of tree and sapling, while Rhizophora mucronata Lamk had the highest IVI value at the stage of seedling. Tabongo mangrove area was a Scrub or dwarf forest type generally. This type was classified as a typical mangrove found in low edges. The mangrove condition in the coastal area of Tabongo Village, Boalemo, was categorized as broken (TNS1 = 210). While based on Assessment of criticality level of mangrove land based on the way teristris, formula was categorized as not broken (TNS2= 330). The reduction strategy that could be implemented to recover the quality of mangrove areas include (i) the assessment of the importance of the mangrove areas with regard to their ecological and economic value, (ii) quality improvement of mangrove habitat, (iii) educational approach by making the mangrove areas as learning media and source, and (iv) empowerment of people living around the mangrove areas.
Applied theatre in times of terror: Accepting aesthetic diversity and going beyond dilemma
Authors: Rasmussen Bjørn 
Published: December 2017

Abstract
Through historical evidence and a research review, the positive assumption behind the Norwegian project is that theatre may provide democratic inclusion where any felt understanding can be accepted as aesthetically valid insights to be uttered on stage. This is how drama is created, and ultimately how diversity is treated and tolerated. However, dilemmas occur when applied theatre aims to be participatory democracy in action. These dilemmas, which are linked to conflicting practices and discourses, as the French philosopher Jacques Rancière (2004) shows, also connect to conflicting aesthetic thinking or regimes. The particular dilemma discussed here deals with the location of aesthetic autonomy as well as the dilemma of free utterance versus transformed mediation. A short analysis of two contemporary performance cases further illuminates the dilemma.
The performance of cultural democracy in the light of care regimes
Authors: Gjærum Rikke Gürgens 
Published: December 2017

Abstract
This article explores how cultural democracy is performed in care services for people with dementia, refugees and psychiatric patients in today’s Norwegian welfare state. The potential of art to emerge as an alternative care regime is discussed in the light of arts learning, marginalization and the Eichmann problem. The article is based on a study of three analyses of care regimes seen as performances in line with Gadamer’s view of the aesthetic experience performed with roles, inherent narratives and scenographic frameworks.
Self-perceived leadership behaviors of undergraduates: Scale development study <p>Lisans öğrencilerinin liderlik davranışlarına ilişkin öz algıları: Ölçek geliştirme çalışması
Authors: Özbek Oğuz , Kızılyallı Meltem 
Published: December 2017

The aim of the study is to develop a valid and reliable instrument to assess the self-perceived leadership behaviors of Sport Sciences undergraduates. 24 undergraduate students defined the leadership concept, data collected were content analyzed, and the 53-itemed pool was reduced to 50 items preceding a review done by 3 scholars. Pilot instrument was administered to 284 Sport Sciences students. KMO (.934) and Bartlett test [4809.978; (p<0.000)] were conducted. Exploratory Factor Analysis revealed 4 factors. 4 Factors in total accounts for the % 54.12 of total variance. Factors generated were named as Participative Leader, Self- confident Leader, Principled Leader and Decisive Leader. Confirmatory Factor Analysis was run and Critical N (CN) was calculated as 252.11 Adaptive values of the model was determined as X2/df (1,39); RMSEA (0.037); NFI (0.97); CFI (0.99); GFI (0.93). The results indicated the model provided a good fit to the data.The results indicated Self-perceived leadership behaviors of undergraduates scale with 4 factors and 20 items is valid and reliable.Extended English abstract is in the end of Full Text PDF (TURKISH) file. ÖzetBu çalışmanın amacı, spor bilimleri lisans öğrencilerinin kendi liderlik davranışlarını değerlendirebilecekleri geçerli ve güvenilir bir ölçme aracı geliştirmektir. 24 öğrenci liderliğin tanımını yapmış, toplanan veriler içerik analizi tekniğiyle analiz edilmiş, 53 maddelik soru havuzu, alınan 3 uzman görüşü sonucu 50’ye indirilmiştir. Ölçeğin deneme formu, spor bilimleri fakültesi öğrencisi 284 kişiye uygulanmıştır. KMO (.934) ve Bartlett testi [4809.978; (p<0.000)] yapılmıştır. Açımlayıcı Faktör Analizi sonucu maddeler 4 ayrı boyutta toplanmıştır. Bu dört boyut toplam varyansın % 54.12’sini açıklamaktadır. Boyutlar, Katılımcı Lider, Kendine Güvenen Lider, İlkeli Lider ve Kararlı Lider olarak isimlendirilmiştir. Doğrulayıcı Faktör Analizi sonucu kritik N değeri 252.11 olarak hesaplanmıştır. Modelin uygunluğuna ilişkin X2/df değeri 1,39; RMSEA değeri 0.037; NFI değeri 0.97; CFI değeri 0.99 ve GFI değeri 0.93 olarak tespit edilmiştir. Bu sonuçlar modelin iyi uyum değerlerini karşıladığını göstermiştir. Dört boyut ve yirmi maddeden oluşan Lisans Öğrencilerinin Liderlik Davranışlarına İlişkin Öz Algıları Ölçeği’nin geçerli ve güvenilir olduğuna karar verilmiştir.
The effect of television advertisements upon food consumption of students<p>Televizyon reklamlarının öğrencilerin besin tüketimi üzerine etkisi
Authors: Özpulat Funda 
Published: December 2017

This descriptive study was planned for the purpose of examining the effect of television advertisements upon food consumption of secondary and high school students. The study was conducted with voluntary students (n=411) between 12.04.2016-30.05.2016 and no sample was selected in the study. It was determined that students who participated in the study were aged 11-17 and had an arithmetical average of 14.45±1.70. As a result of the study, it was determined that the state of students to immediately buy and consume foods and beverages appearing on television advertisements changed according to schools. Besides, it was observed that the state of students to get impressed by food advertisements changed according to their gender, female students were influenced by food advertisements at a higher rate and there was no statistically significant relationship between gender and the state of getting impressed by beverage advertisements. As well as training to be provided to these age groups; consciousness and awareness to be raised in them will directly affect their present and future lives.Extended English abstract is in the end of Full Text PDF (TURKISH) file. ÖzetBu çalışma, ortaokul ve lise öğrencilerinin beslenme durumunu ve televizyon reklamlarının besin tüketimleri üzerine etkisini saptamak amacıyla planlanmış tanımlayıcı türde bir araştırmadır. 12.04.2016-30.05.2016 tarihleri arasında yürütülen araştırmada örneklem seçimine gidilmemiş, araştırmaya gönüllü olarak katılmayı kabul eden öğrencilerle (n=411) çalışma yürütülmüştür. Araştırmaya katılan öğrencilerin yaşları 11 ile 17 arasında değişmekte, aritmetik ortalamasının 14.45±1.70 olduğu görülmektedir. Araştırma sonunda, okullara göre öğrencilerin televizyon reklamlarındaki yiyecek ve içecekleri hemen alıp tüketme durumunun değiştiği saptanmıştır. Ayrıca, öğrencilerin cinsiyetine göre yiyecek reklamlarını etkili bulma durumunun değiştiği, kız öğrencilerin yiyecek reklamlarından daha fazla etkilendiği, cinsiyetle içecek reklamını etkili bulma durumu arasında ise istatistiksel olarak anlamlı bir ilişki bulunmadığı görülmüştür. Bu yaş gruplarına verilecek eğitim, kazandırılacak bilinç ve farkındalık, öğrencilerin şimdiki ve gelecekteki yaşamlarını doğrudan etkileyecektir.
Fourier ptychography for high space-bandwidth product microscopy
Authors: Bian Liheng , Suo Jinli , Dai Qionghai , Chen Feng 
Published: December 2017

Abstract
Fourier ptychography is a novel imaging technique with high space-bandwidth product (SBP) on the scale of gigapixel, and has been successfully applied for high-resolution and large field-of-view (FOV) microscopy, termed Fourier ptychographic microscopy (FPM). FPM utilizes a low-numerical-aperture objective lens to capture multiple large FOV but low-resolution images under angularly varying illumination, and uses phase-retrieval algorithms to reconstruct the sample’s high-resolution amplitude and phase information. FPM is advantageous over conventional high SBP microscopy techniques in many aspects, including no mechanical scanning, computational acquisition of both amplitude and phase, extended depth of focus, long working distance, and high compatibility with current microscopes. In this paper, we review FPM with its principles, multiple techniques to improve its performance, and its various applications and extensions.
Vortex assisted-supramolecular solvent based microextraction coupled with spectrophotometric determination of triclosan in environmental water samples
Authors: Mpupa Anele , Mashile Geaneth P. , Nomngongo Philiswa N. 
Published: December 2017

AbstractA simple, fast and environmental friendly vortex assisted-supramolecular solvent based microextraction (VA-SSME) method was developed for the preconcetration of triclosan in wastewater prior to UV spectrophotometric determination. To achieve maximum sensitivity and accuracy for the target analyte, the experimental parameters affecting the VA-SSME procedure were optimized using response surface methodology (RSM). Under optimised conditions, the correlation coefficient (R2) and recoveries were 0.9994 and 100.31-118.5%, respectively. The intra-day (repeatability) and inter-day (reproducibility) precisions expressed in terms of relative standard deviation (RSD) were 2-4% and 5.2%, respectively. The preconcentration factor and limits of detection (LOD) and quantification (LOQ) were found to be 90, 0.28 μg L−1and 0.92 μg L−1, respectively. The developed VA-SSME/UV method was applied for the determination of triclosan in real samples collected over a period of three months. The analytical results obtained showed that triclosan was frequently detected in influent wastewater samples but was not detected in effluent samples.
Evaluation of temporary seasonal variation of heavy metals and their potential ecological risk in Nzhelele River, South Africa
Authors: Edokpayi Joshua N. , Odiyo John O. , Popoola Elizabeth O. , Msagati Titus A.M. 
Published: December 2017

AbstractSurface water is often used as alternative source of drinking water in many regions of the world where the potable water supply is erratic or not present. The concentration of heavy metals was assessed using an Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES). The impact of temporary seasonal variation on the contamination level was also assessed. Contamination factor (CF) and Hakanson’s potential ecological risk (Erand RI) indices were used to evaluate the toxicity levels of the metals in the sediments of the river. Higher concentrations of Fe, Mn, Pb, Cu and Zn were determined in the dry season in the river water whereas in the sediments higher levels were recorded for Al, Fe, Cd, Cr, Cu and Zn in the wet season. The average CF values for all the metals showed a low contamination level in the sediment, except for Cu and Cd which had moderate and considerable contamination levels, respectively. Similarly, Cu showed a moderate ecological risk level (Er= 62.90) only in March 2014, for other months Cu and the other metals investigated had Ervalues < 40 which implies low ecological risk. The mean relative abundance of heavy metals in the sediments follows the trend Al>Fe>Mn>u>Zn>Cr>Pb>Cd.