bluuebunny/crossref_metadata_2025_split huggingface dataset:
AVALIAÇÃO DA ATIVIDADE CITOTÓXICA E ANTITUMORAL IN VITRO E IN VIVO DE EXTRATOS DA Urtica dioica L.:
Authors: Lopes Yoná Christina de Andrade , Sousa Francisca Jennifer Carvalho de 
Published: September 2024

Introdução: A Urtica dioica é uma planta perene comestível muito utilizada desde a antiguidade na medicina tradicional para o tratamento de diversas doenças, tais como diabetes, reumatismo, coadjuvante no tratamento de hiperplasia prostática, na prevenção de doenças do sistema cardiovascular, como antimicrobiano, dentre outros. Objetivo: realizar uma revisão com as informações disponíveis na literatura científica dos extratos obtidos de partes vegetais de U. dioica com atividade anticâncer e citotóxica, bem como elucidar a ação antioxidante dos extratos sobre as células tumorais tanto em modelos animais quanto in vitro. Metodologia: A busca de dados foi realizada por meio das bases de dados Web of Science, LILACS e MEDLINE via PubMed, para a coleta de estudos publicados anteriormente à agosto de 2024. Para a pesquisa foi utilizado os termos e palavras-chave, como: “Cytotoxicity”, “Cancer”, “Medicinal plants”, “Urtica dioica” e “Phytotherapy”, utilizando a estratégia de busca com a combinação de operadores booleanos “AND”. Após a análise dos critérios, foram selecionados 10 artigos para constituir a discussão dos resultados. Resultados: As informações disponíveis na literatura científica acerca de compostos bioativos com atividade citotóxica e antitumoral, observando os resultados de tratamentos com extrato de U. dioica a nível celular e molecular em várias linhagens de células cancerosas em modelos experimentais in vitro e in vivo. Considerações: Os extratos estudados da U. dioica podem agir como anticancerígeno em vários mecanismos através da ação do metabolismo, na inibição do crescimento celular, na indução das expressões de genes pró-apoptóticos, antiapoptóticos e nas proteínas envolvidas na via apoptótica em diferentes linhagens de células cancerosas in vitro e de modelos animais de câncer, devido a suas propriedades citotóxicas e antitumoral. No entanto, observou-se a escassez de estudos que tenham foco na atividade antioxidante, desse modo, mais investigações são necessárias para identificar o(s) composto(s) ativo(s) nos extratos da U. dioica.
Improving the Efficiency of Applying Thermal Energy into the Formed Protective Coatings Based on Rubber Mastic
Authors: Сапелкин Р.И. , Матренинский С.И. , Мищенко В.Я. , Бредихина Н.В. 
Published: September 2024

Постановка задачи. Для устройства защитного покрытия трубного металла из низкомолекулярного олигодиена (каучуковой мастики) необходимо обеспечить внесение в материал покрытия требуемого количества тепловой энергии, что посредством вулканизации каучуковой мастики формирует высокие физико-механические и эксплуатационные характеристики защитного слоя. Данный результат может быть достигнут путем разработки и применения высокоэффективных теплогенерирующих устройств. Результаты. Предложен способ эффективного внесения тепловой энергии в каучуковую мастику методом индукционного нагрева трубного металла, а также разработано и сконструировано опытное теплогенерирующее устройство, реализующее данный способ и обеспечивающее необходимые режимы термообработки композиционного материала покрытия. Выводы. Сконструированное теплогенерирующее устройство, реализующее эффективный способ внесения тепловой энергии в каучуковую мастику, позволяет обеспечить необходимый температурный режим в целях формирования защитного покрытия с необходимым набором физико-механических и эксплуатационных характеристик.
Statement of the problem. For the device of a protective coating of tubular metal made of low molecular weight oligodiene (rubber mastic), it is necessary to ensure that the required amount of thermal energy is introduced into the coating material, which, through vulcanization of rubber mastic, forms high physical, mechanical and operational characteristics of the protective layer. This result can be achieved through the development and application of highly efficient heat generating devices. Results. A method for the effective introduction of thermal energy into rubber mastic by induction heating of tubular metal is proposed, and an experimental heat generating device has been developed and constructed that implements this method and provides the necessary heat treatment modes for the composite coating material. Conclusions. The designed heat generating device, which implements an effective method of introducing thermal energy into rubber mastic, allows to ensure the necessary temperature regime in order to form a protective coating with the necessary set of physical, mechanical and operational characteristics.
Prefab: New Technologies and Prospects of the Construction Industry
Authors: Евсевнина Е.Д. , Воробьев В.С. 
Published: September 2024

Состояние проблемы. Основными факторами в строительной отрасли являются: стоимость реализации проекта, его продолжительность и уникальность. Их достижению способствует развиваемая в настоящее время префабрикация, суть которой сводится к фабричному или заводскому изготовлению деталей с последующей их сборкой в конструктивные элементы, модули и в целом объекты. Вместе с тем до настоящего времени не отработаны технологии, организация строительства и управление префаб-процессами. Результаты. Предложен системный обзор реализации зданий по префаб-технологии с высокой фабричной готовностью. Приведен обзор модулей, которые могут быть интегрированы в проекты, построенные на месте, с меньшим количеством отходов и более высоким контролем качества по сравнению с проектами, в которых используется традиционный тип строительства. Подчеркнуто отличие метода префабрикации от модульной сборки строительного объекта. Дан обзор префаб-продуктов, представленных на рынке в настоящее время. Выводы. Обоснованы направления повышения качества производимых зданий, присущих префаб-технологиям, а также экологичность и энергоэффективность данной технологии. Приведен фрагмент BIM-модели с календарно-строительным графиком строительства префаб-дома, префаб-технологии, применяемых в России и, в частности, в г. Новосибирске.
Statement of the problem. The main factors in the construction industry are: the cost of the project, its duration and uniqueness. Their achievement is facilitated by the currently developing pre-fabrication, the essence of which is reduced to the factory or factory manufacture of parts with their subsequent assembly into structural elements, modules and objects in general. At the same time, technologies, organization of construction and management of prefab processes have not been worked out to date. Results. A systematic review of the implementation of buildings using prefab technology with high factory readiness is proposed. An overview of modules that can be integrated into on-site projects with less waste and higher quality control compared to projects that use a traditional type of construction is provided. The difference between the prefab method and the modular assembly of a construction object is emphasized. An overview of the prefab products currently on the market is given. Conclusions. The article substantiates the directions of improving the quality of manufactured buildings inherent in prefab technologies, as well as the environmental friendliness and energy efficiency of this technology. A fragment of a BIM model with a calendar and construction schedule for the construction of a prefab house, prefab technologies used in Russia and in particular in Novosibirsk, is presented.
Analysis of a Design Solution for the Bearing Structure of an Industrial Building Using the LIRA-SAPR Software Complex
Authors: Пушкарев И.А. , Рычина С.А. 
Published: September 2024

Постановка задачи. Проведен анализ конструктивного решения несущей конструкции производственного здания по двум вариантам расчетных схем при использовании программного комплекса «ЛИРА-САПР». Результаты. С помощью программного комплекса «ЛИРА-САПР» были рассмотрены два варианта конструирования, что создало полное представление о работе профиля и подтвердило необходимость проверки элементов фермы с учетом возникновения изгибающего момента в случае жесткого сопряжения стержней. Стремительное развитие программных комплексов дает возможность рассчитать различные варианты схем конструкций и сократить время данной операции. Принимая в расчетных моделях различные типы соединения, пользователь может наглядно увидеть наиболее выгодное напряженно-деформированное состояние стержней ферм, что, в свою очередь, позволит избежать негативных последствий при эксплуатации производственного здания. Выводы. Построены мозаики усилий с жестким и шарнирным сопряжением стержней в узлах фермы, которые показали, что в элементах верхнего пояса и восходящих раскосах наибольший процент использования сечений соответствует проверке на устойчивость, а в элементах нижнего пояса и нисходящих раскосах наибольший процент использования сечений приходится на проверку по нормальным напряжениям. В ферме с жестким сопряжением стержней в узле процент использования сечения выше, чем при шарнирном соединении, как при проверке по нормальным напряжениям, так и по устойчивости.
Statement of the problem. An analysis of the design solution of the load-bearing structure of an industrial building was carried out using two variants of design schemes, using the LIRA-SAPR software package. Results. Using the Lyra-SAPR software package, two design options were considered, which created a complete picture of the operation of the profile and confirmed the need to check the truss elements taking into account the occurrence of a bending moment in the case of a rigid coupling of the rods. The rapid development of software systems makes it possible to calculate various options for structural schemes and reduce the time of this operation. By accepting various types of connections in the calculation models, the user can clearly see the most favorable stress-strain state of the truss rods, which in turn will help avoid negative consequences during the operation of the industrial building. Conclusions. Mosaics of forces with rigid and hinged coupling of rods in the truss nodes were constructed, which showed that in the elements of the upper chord and ascending braces the largest percentage of the use of sections corresponds to the stability test, and in the elements of the lower chord and descending braces the largest percentage of the use of sections falls on the normal test stress. In a truss with a rigid coupling of bars in a node, the percentage of section utilization is higher than with a hinged connection, both when tested by normal stresses and by stability.
Territorial Devaluation of Architectural Objects: Reasons and Ways to Overcome
Authors: Чикота С.И. 
Published: September 2024

Состояние проблемы.Архитектурные объекты возводятся с учетом функционального зонирования территории. Они неразрывно связаны с земельным участком, являясь объектами недвижимости. В ряде случаев из-за связи с конкретной территорией архитектурные объекты, даже без видимых признаков физического или морального износа, выводятся из эксплуатации, что предлагается характеризовать как территориальную девальвацию. Результаты. На конкретных примерах населенных пунктов Уральского региона выявлены и проанализированы различные причины, вызывающие территориальную девальвацию архитектурных объектов. Обозначены также пути преодоления данного явления. Выводы. К основными причинами, ведущим к территориальной девальвации архитектурных объектов, относятся: утрата территорией первоначального функционального назначения; влияние промышленных предприятий на экологию территории; отток населения из населенного места; изменение демографического состава населения территории; стагнация предприятий; престижность территории и высокая стоимость земельного участка. В случае устранения причин, вызвавших территориальную девальвацию архитектурного объекта, используя капитальный ремонт или реставрацию, можно произвести его реновацию. Кардинальным способом сохранения архитектурного объекта при территориальной девальвации является его реконструкция с изменением функционального назначения.
Statement of the problem. Architectural objects are erected taking into account the functional zoning of the territory. They are inextricably linked with the land plot, being real estate objects. In a number of cases, due to their connection with a specific territory, architectural objects, even without visible signs of physical or moral wear and tear, are taken out of service, which is proposed to be characterized as «territorial devaluation». Results. Using specific examples of settlements in the Ural region, various reasons causing the territorial devaluation of architectural objects have been identified and analyzed. Ways to overcome this phenomenon are also outlined. Conclusions. The main reasons leading to the territorial devaluation of architectural objects include: loss of the territory’s original functional purpose; the influence of industrial enterprises on the ecology of the territory; outflow of population from a populated area; changes in the demographic composition of the territory's population; stagnation of enterprises; prestige of the territory and high cost of land. If the reasons that caused the territorial devaluation of an architectural object are eliminated, using major repairs or restoration, it can be renovated. The fundamental way to preserve an architectural object during territorial devaluation is its reconstruction with a change in functional purpose.
DAMPAK KEBERADAAN ATRAKSI WISATA MANDI SAKRAL DI KAWASAN PURA SURANADI TERHADAP EKONOMI MASYARAKAT
Authors: PRAYITNO JOKO 
Published: September 2024

Lombok is one of the tourist destinations in Indonesia which has many tourist attractions. The sacred bathing tourist attraction in Suranadi Temple area is one of them. From my observations, tourists visiting this area not only carry out rituals, but tourists also enjoy traditional culinary delights with basic objectives, reasons, and argumentative factors. The existence of this tourist destination has an impact on the economic aspect. Based on observations, literature studies, and interviews with several residents and temple managers, the findings strengthen the community's view that tourism can have an impact on the economic growth of the Suranadi community.

Keywords: Economy, sacred bath, Suranadi.
RELEVÂNCIA DA PRODUÇÃO DE TAPEREBÁ (SPONDIAS MOMBIN) E SEUS ENTRAVES: LEVANTAMENTO BIBLIOGRÁFICO
Authors: AMARAL A. B. do. , FERREIRA A. K. de A. , NEVES L. I. A. , CARDOSO A. T. A. , RIBEIRO L. R. da T. , RAMOS N. A. , MAIA B. K. da S. , SOARES L. B. , COSTA C. V. da C. , ALMEIDA V. P. P. de. 
Published: September 2024

A cajazeira (Spondias mombin L.) pertence à família Anacardiaceae, tem alto valor comercial e crescente demanda. O taperebá pode ser propagado por via sexuada e assexuada. Em relação à morfologia da planta, árvores maiores atingem dimensões próximas de 30 metros, a copa varia de 8 metros a 24 metros de diâmetro. Os entraves encontrados na produção do cajá estão na geração de árvores oriundas de propagação sexuada e problemas fitotécnicos. O taperebá se encontra no grupo dos vegetais, mas também se enquadra no uso medicinal. A média percentual de rendimento em polpa atinge 40%, podendo ser compensado pelas marcantes características de aroma e sabor. A cajazeira propagada por sementes começa a produzir seis ou sete anos após o plantio, enquanto plantas clonadas por enxertia produzem após o terceiro ano de cultivo. A produção de polpa é a principal destinação dos frutos de Spondias mombin e sua comercialização ocorre por quilo. Apesar de no Brasil não existirem estatísticas oficiais sobre a produção, pode-se estimar que cerca de 20 mil toneladas de frutos são geradas anualmente. No supermercado Mais Barato, localizado no município de Belém, os valores de polpa se encontram em R$ 20,45 e R$ 20,15. As dificuldades estão na geração de árvores oriundas de propagação sexuadas, problemas fitotécnicos, como germinação irregular e distribuída ao longo do tempo e o baixo poder germinativo das sementes. Apesar dos gargalos e desafios existentes na produção da cajarana, pode-se concluir que a frutífera tem relevância alimentar, medicinal, ambiental e social.
Tim Apoteker dan Tim IYPG IAI Gorontalo dalam Bantuan Kesehatan Korban Banjir di Gorontalo
Authors: Paneo Mohamad Aprianto , Thomas Nurain , Latif Multiani S , Puluhulawa Lisa Efriani , Mo'o Faradila Ratu Cindana , Rismayani Nur 
Published: September 2024

Banjir di Provinsi Gorontalo yang terjadi pada bulan juli tahun 2024 menyebabkan dampak yang signifikan terhadap kesehatan masyarakat, memerlukan tindakan cepat dari tim relawan medis. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan bantuan kesehatan kepada korban banjir melalui pelayanan medis darurat, edukasi kesehatan, dan distribusi obat-obatan. Tim medis relawan bekerja sama dengan pemerintah setempat dan komunitas lokal untuk memastikan penanganan kesehatan yang efektif dan tepat sasaran. Metode pengabdian dengan memberikan layanan kesehatan yang mencakup pemberian obat-obat untuk meredakan penyakit akut, pencegahan penyakit menular, beberapa suplemen menunjang kesehatan, makanan, minuman, kebutuhan bayi, manula serta beberapa kebutuhan untuk menunjang pemulihan kondisi kesehatan masyarakat pascabencana. Pengabdian dilakukan dibeberapa titk pasca banjir wilayah kota dan kabupaten gorontalo. Hasil kegiatan ini menunjukkan bahwa respons cepat relawan dalam memberikan bantuan kesehatan berhasil mengurangi angka kejadian penyakit pascabencana dan meningkatkan kesadaran masyarakat akan pentingnya kesiapsiagaan menghadapi bencana. Selain itu banyak masyarakat yang sangat terbantu dengan kegiatan ini dilihat dari respon saat tim memberikan bantuan. Kegiatan ini menegaskan pentingnya kolaborasi lintas sektor dan pelatihan berkelanjutan bagi relawan medis dalam menghadapi situasi darurat bencana.
Pemasaran Produk dengan Pendekatan AIDA oleh Influencer di Media Sosial TikTok
Authors: Tjoa Hans Benedict , Sutjipto Catherine Christabel , Valerie Valencia , Wijayanti Sri Hapsari 
Published: September 2024

Dewasa ini media sosial cukup banyak digunakan para pemasar, termasuk influencer, untuk mempromosikan produk atau jasa. Salah satu teknik promosi yang dimanfaatkan sebagai acuan penyusunan konten di media sosial adalah pendekatan AIDA. AIDA merupakan tahapan pemasaran yang efektif, dimulai dari memikat hati audiens (attention), menumbuhkan minat (interest), membangkitkan kemauan (desire), serta memotivasi tindakan audiens (action). Tujuan penelitian ini adalah mendeskripsikan pendekatan AIDA yang digunakan influencer NS di TikTok saat memasarkan alat perlengkapan rumah tangga. Penelitian ini bersifat deskriptif kualitatif dengan teknik observasi terhadap tayangan video dan analisis isi atas ketiga video milik influencer NS. Ketiga video tersebut ditayangkan pada 2023 dan dipilih secara random sebagai objek penelitian. Analisis isi berpedoman pada tahapan AIDA, yaitu attention, intereset, desire, dan action. Dari penelitian ini ditemukan bahwa pendekatan AIDA dalam pemasaran di TikTok dapat membantu influencer menggiring audiens dari rasa ingin tahu, tertarik, hingga berpikir untuk bertindak. Pemasaran yang dilakukan dengan menggunakan TikTok tergolong softsale karena lebih sederhana dan efektif untuk diterapkan.
Complicated intraductal papillary mucinous neoplasia requiring a two-stage operation
Authors: Marinov Vesselin , Karagyozоv Petko , Kostov Konstantin , Emilova Niya , Ivanova Stefka , Chaneva Mariya , Atanasova Ventseslava Petrova , Atanasov Petar , Vakrilova Becheva Maria 
Published: September 2024

Introduction: Intraductal papillary mucinous neoplasia (IPMN) is a benign cystic neoplasm that has the potential to transform into pancreatic cancer over time. These lesions are usually asymptomatic. A main pancreatic duct IPMN is usually symptomatic and may present as an emergency when occlusion of the common bile duct with thick mucinous secretion and jaundice develop. This complication is hard to manage pharmacotherapeutically or by endoscopic procedure and may require surgical treatment.
Purpose: This is a case report of a complicated main pancreatic duct IPMN that required an urgent, two-stage operation. A review of the literature on the topic was carried out.
Case description: A 67-year-old male patient with symptoms of jaundice was diagnosed with acute cholangitis, cholecystitis, and pancreatitis as complications of the mucinous obstruction of the main pancreatic duct and of the common bile duct (CBD) caused by IPMN. The condition was confirmed by cholangio-pancreatoscopy and biopsy. Stenting of CBD was attempted, but the procedure turned out unsuccessful, and we proceeded to an emergency two-stage operation. The first operation consisted of the clearance of the bile ducts from infected mucinous secretion, cholecystectomy, and hepatico-jejunostomy. A Whipple procedure was performed as a second-stage operation.
Discussion: Cases of emergency are not common in patients with IPMN. However, obstructive jaundice by mucinous secretion due to the disease is hard to treat only by endoscopy because of the high risk of obstruction of the endoprosthesis. On the other hand, emergency pancreatic resections are associated with a high risk of perioperative complications.
Conclusion: Sometimes, the complicated main pancreatic duct IPMNs can pose a challenge for the interdisciplinary team of invasive gastroenterologists and surgeons, and the key to a successful outcome is surgical interventions in two- or three stages that include complications management as the first stage, followed by surgical resection as a second stage operation. Biliary drainage improvement is usually only temporarily successful with the insertion of biliary stents because of the rapid mucinous occlusion and the remaining risk of cholangitis and cholecystitis.
Quality of work life and factors associated with it among elderly workers in Sri Lanka
Authors: Gunathilaka Niluka , Weerasinghe Manuj C. , Samaranayake Dulani 
Published: September 2024

Introduction: The quality of work life (QoWL) of the elderly worke r becomes an important concept which needs to be assessed and improved with the increase of elderly population as their engagement in the workforce is inevitable. Objectives: To assess the prevalence and associated factors of QoW L among the elderly workers in Sri Lanka Methods: A cross-sectional survey study was conducted among el derly workers selected using multi-stage cluster sampling from Gampaha District. The QoWL was assessed using newly developed and validated Quality of Work Life Scale Elderly Workers. Factors associated with good QoWL were assessed through interviewer-administered questionnaire. Using a consensus reached cutoff mark, QoWL was dichotomized into ‘good’ and ‘poor’. Data were analysed with descriptive statistics and factors associated with good QoWL were determined using bivariate analysis with Chi- squared test and multivariate analysis with multiple logistic regression. Results: The study included 835 elderly workers and the mean score for total QoWL was 119.42 (SD=12.18). Prevalence of good QoWL among the elderly workers was 32.1% (95% CI=29.0, 35.3). Good QoWL was significantly associated with multiple factors, such as personal, work related and p sychosocial factors. In the multivariate analysis, factors significantly associated with good QoWL of elder workers were earning more than LKR 30,000 per month, having properties as an income generation method, engaging in a j ob before age 60 years, job helping to have social interaction, having adequate social support and engaging in political activities. Spending on own food, having arthritis, experiencing work related accidents and occupational engagement to support the family were negatively associated with good QoWL. Conclusions & Recommendations: The QoWL of elderly worke rs was at a low level and needs improvement interventions. Employees as well as policymakers should develop a nd implement appropriate strategies to improve their QoWL.