bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability of Pain Measurements Using Computerized Cuff Algometry: A DoloCuff Reliability and Agreement Study
Authors: Kvistgaard Olsen Jack , Fener Dilay Kesgin , Wæhrens Eva Elisabet , Wulf Christensen Anton , Jespersen Anders , Danneskiold‐Samsøe Bente , Bartels Else Marie 
Published: September 2016

AbstractIntroductionComputerized pneumatic cuff pressure algometry (CPA) using the DoloCuff is a new method for pain assessment. Intra‐ and inter‐rater reliabilities have not yet been established. Our aim was to examine the inter‐ and intrarater reliabilities of DoloCuff measures in healthy subjects.MethodsTwenty healthy subjects (ages 20 to 29 years) were assessed three times at 24‐hour intervals by two trained raters. Inter‐rater reliability was established based on the first and second assessments, whereas intrarater reliability was based on the second and third assessments. Subjects were randomized 1:1 to first assessment at either rater 1 or rater 2. The variables of interest were pressure pain threshold (PT), pressure pain tolerance (PTol), and temporal summation index (TSI). Reliability was estimated by a two‐way mixed intraclass correlation coefficient (ICC) absolute agreement analysis. Reliability was considered excellent if ICC > 0.75, fair to good if 0.4 < ICC < 0.75, and poor if ICC < 0.4. Bias and random errors between raters and assessments were evaluated using 95% confidence interval (CI) and Bland–Altman plots.ResultsInter‐rater reliability for PT, PTol, and TSI was 0.88 (95% CI: 0.69 to 0.95), 0.86 (95% CI: 0.65 to 0.95), and 0.81 (95% CI: 0.42 to 0.94), respectively. The intrarater reliability for PT, PTol, and TSI was 0.81 (95% CI: 0.53 to 0.92), 0.89 (95% CI: 0.74 to 0.96), and 0.75 (95% CI: 0.28 to 0.91), respectively.ConclusionInter‐rater reliability was excellent for PT, PTol, and TSI. Similarly, the intrarater reliability for PT and PTol was excellent, while borderline excellent/good for TSI. Therefore, the DoloCuff can be used to obtain reliable measures of pressure pain parameters in healthy subjects.
Pain, Itch, Quality of Life, and Costs after Herpes Zoster
Authors: van Wijck Albert J.M. , Aerssens Yannick R. 
Published: September 2016

AbstractBackgroundHerpes zoster (HZ) and postherpetic neuralgia are known to have a profound effect on the patient's quality of life, but the incidence and severity of itch and its relation with pain and quality of life in the long term are still relatively unknown.ObjectiveThe aim of this study was to measure the presence and severity of pain and itch and impact on quality of life in patients over 50 years old with HZ.MethodsWe enrolled 661 patients with HZ in this 12‐month observational study. Patient data were collected via a web‐based questionnaire. Outcomes were pain, itch, burden of illness, impact on patient's daily life, impact on quality of life, and healthcare costs.ResultsAt inclusion, 94% of patients reported any pain, 74.3% significant pain, and 26% severe pain. After 3 months, 18.8% of patients suffered from postherpetic neuralgia. At inclusion, 70.8% of patients had any itch, 39.2% significant itch, and 7.3% severe itch. The occurrence of pain increases costs and has a high impact on the quality of life, lowering EQ‐5D scores by an average of 18%. In contrast, itch has little effect on the quality of life.ConclusionsPain and itch are highly prevalent months after HZ. Pain caused by HZ has a large impact on quality of life, burden of illness, impact on daily life, and health care costs for these patients. The impact of itch on quality of life is relatively small.
Comparison between group and personal rehabilitation for dementia in a geriatric health service facility: single‐blinded randomized controlled study
Authors: Tanaka Shigeya , Honda Shin , Nakano Hajime , Sato Yuko , Araya Kazufumi , Yamaguchi Haruyasu 
Published: September 2016

AimThe aim of this study was to compare the effects of rehabilitation involving group and personal sessions on demented participants.MethodsThis single‐blinded randomized controlled trial included 60 elderly participants with dementia in a geriatric health service facility, or R
oken. Staff members, who did not participate in the intervention, examined cognitive function, mood, communication ability, severity of dementia, objective quality of life, vitality, and daily behaviour. After a baseline assessment, participants were randomly divided into three groups: (i) group intervention; (ii) personal intervention; and (iii) control. The 1‐h group intervention (3–5 subjects) and 20‐min personal intervention (one staff member per participant) were performed twice a week for 12 weeks (24 total sessions). The cognitive rehabilitation programme consisted of reminiscence, reality orientation, and physical exercise, and it was based on five principles of brain‐activating rehabilitation; (i) pleasant atmosphere; (ii) communication; (iii) social roles; (iv) praising; and (v) errorless support. Data were analyzed after the second assessment.ResultsOutcome measures were analyzed in 43 participants—14 in the control group, 13 in group intervention, and 16 in personal intervention. Repeated measure ancova showed a significant interaction for cognitive function score (Mini‐Mental State Examination) between group intervention and controls (
F
= 5.535, P = 0.029). In the post‐hoc analysis, group intervention showed significant improvement (P = 0.016). Global severity of dementia tended to improve (P = 0.094) in group intervention compared to control (Mann–Whitney
U
‐test). There were no significant interactions or improvements for other measurements.ConclusionsGroup rehabilitation for dementia is more effective for improving cognitive function and global severity of dementia than personal rehabilitation in Roken.
Ernest S. Griffith: A Renaissance Man, a Pioneering Public Administrator
Authors: Stathis Stephen W. 
Published: September 2016

Abstract
In the 1940s and 1950s, Ernest Stacey Griffith was well known on Capitol Hill and frequently featured in major newspaper and magazine articles about the work of Congress. He was also recognized as an influential scholar. Today, few members of Congress and only a handful of the thousands employed by the legislative branch have ever heard of him. Even at the Congressional Research Service—Congress's think tank—which he headed for 18 years, Griffith is mostly an unfamiliar name. During his century‐long life, this Rhodes Scholar left an indelible legacy in several arenas. Griffith was not only a pioneering advisor to the nation's legislators and an astute observer of American democracy, he also achieved acclaim as a public administrator, an innovative teacher and educator, an early supporter of the conservation movement, a prominent community and religious leader, and a record‐setting mountain climber.
Interstate Spillovers, Fiscal Decentralization, and Public Spending on Medicaid Home‐ and Community‐Based Services
Authors: Oyun Gerel 
Published: September 2016

Abstract
This article examines the interstate spillover effect of Medicaid expenditures for home‐ and community‐based services (HCBS) and tests the relationship between fiscal decentralization and public spending. Based on the theory of interstate strategic interaction, an empirical model is specified that explicitly accounts for interdependence in states’ spending decisions. The model is estimated by applying spatial econometric methods to panel data for the 50 U.S. states for 2000–2010. Findings show a positive interdependence in state HCBS expenditures that is contingent on similarity in citizen ideology between states. Fiscal decentralization, measured by transfer dependence and revenue autonomy, is positively related to Medicaid HCBS spending.
Impact of grasshoppers and an invasive grass on establishment and initial growth of restoration plant species
Authors: Cumberland Catherine , Jonas Jayne L. , Paschke Mark W. 
Published: September 2016

AbstractExotic plant invasion can have dramatic impacts on native plants making restoration of native vegetation at invaded sites challenging. Though invasives may be superior competitors, it is possible their dominance could be enhanced by insect herbivores if native plants are preferred food sources. Insect herbivory can regulate plant populations, but little is known of its effects in restoration settings. There is a need to better understand relationships between insect herbivores and invasive plants with regard to their combined potential for impacting native plant establishment and restoration success. The objective of this study was to assess impacts of grasshopper herbivory and the invasive grass Bromus tectorum (cheatgrass) on mortality and growth of 17 native plant species used in restoration of critical sagebrush steppe ecosystems. Field and greenhouse experiments were conducted using moderate densities of a common, generalist pest grasshopper (Melanoplus bivittatus). Grasshoppers had stronger and more consistent impacts on native restoration plants in field and greenhouse studies than cheatgrass. After 6 weeks in the greenhouse, grasshoppers were associated with 36% mortality over all native restoration species compared to 2% when grasshoppers were absent. Herbivory was also associated with an approximately 50% decrease in native plant biomass. However, effects varied among species. Artemisia tridentata, Chrysothamnus viscidiflorus, and Coreopsis tinctoria were among the most negatively impacted, while Oenothera pallida, Pascopyrum smithii, and Leymus cinerus were unaffected. These findings suggest restoration species could be selected to more effectively establish and persist within cheatgrass infestations, particularly when grasshopper populations are forecasted to be high.
Does the Degree of Development Matter in the Impact of Banking Crises on International Trade?
Authors: Gil‐Pareja Salvador , Llorca‐Vivero Rafael , Martínez‐Serrano José Antonio 
Published: September 2016

AbstractThis paper analyzes how a country's degree of economic development affects the impact of banking crises on international trade. To this end, we estimate a gravity model of trade using a sample of 139 countries over the period 1975–2012. Our results show that middle income countries are generally the most negatively affected. In contrast, financial turmoil appears to have less impact on bilateral trade flows among high income countries and, more specially, among low income nations. The level of financial development, contract enforcement, as well as the extent of the use of banking credit within international trade all help to explain our findings.
Efficient production of biallelic GGTA1 knockout pigs by cytoplasmic microinjection of CRISPR/Cas9 into zygotes
Authors: Petersen Bjoern , Frenzel Antje , Lucas‐Hahn Andrea , Herrmann Doris , Hassel Petra , Klein Sabine , Ziegler Maren , Hadeler Klaus‐Gerd , Niemann Heiner 
Published: September 2016

AbstractBackgroundXenotransplantation is considered to be a promising solution to the growing demand for suitable donor organs for transplantation. Despite tremendous progress in the generation of pigs with multiple genetic modifications thought to be necessary to overcoming the severe rejection responses after pig‐to‐non‐human primate xenotransplantation, the production of knockout pigs by somatic cell nuclear transfer (SCNT) is still an inefficient process. Producing genetically modified pigs by intracytoplasmic microinjection of porcine zygotes is an alluring alternative. The porcine GGTA1 gene encodes for the α1,3‐galactosyltransferase that synthesizes the Gal epitopes on porcine cells which constitute the major antigen in a xenotransplantation setting. GGTA1‐KO pigs have successfully been produced by transfecting somatic cells with zinc‐finger nucleases (ZFNs), transcription activator‐like effector nucleases (TALENs), or CRISPR/Cas targeting GGTA1, followed by SCNT.MethodsHere, we microinjected a CRISPR/Cas9 vector coding for a single‐guide RNA (sgRNA) targeting exon 8 of the GGTA1 gene into the cytoplasm of 97 in vivo‐derived porcine zygotes and transferred 86 of the microinjected embryos into three hormonally synchronized recipients. Fetuses and piglets were analyzed by flow cytometry for remaining Gal epitopes. DNA was sequenced to detect mutations at the GGTA1 locus.ResultsTwo of the recipients remained pregnant as determined by ultrasound scanning on day 25 of gestation. One pregnancy was terminated on day 26, and six healthy fetuses were recovered. The second pregnancy was allowed to go to term and resulted in the birth of six healthy piglets. Flow cytometry analysis revealed the absence of Gal epitopes in four of six fetuses (66%), indicating a biallelic KO of GGTA1. Additionally, three of the six live‐born piglets (50%) did not express Gal epitopes on their cell surface. Two fetuses and two piglets showed a mosaicism with a mixed population of Gal‐free and Gal‐expressing cells. Only a single piglet did not have any genomic modifications. Genomic sequencing revealed indel formation at the GGTA1 locus ranging from +17 bp to −20 bp.ConclusionsThese results demonstrate the efficacy of CRISPR/Cas to generate genetic modifications in pigs by simplified technology, such as intracytoplasmic microinjection into zygotes, which would significantly facilitate the production of genetically modified pigs suitable for xenotransplantation. Importantly, this simplified injection protocol avoids the penetration of the vulnerable pronuclear membrane, and is thus compatible with higher survival rates of microinjected embryos, which in turn facilitates production of genetically modified piglets.
Stable isotope tracers and exercise physiology: past, present and future
Authors: Wilkinson Daniel J. , Brook Matthew S. , Smith Kenneth , Atherton Philip J. 
Published: September 2016

AbstractStable isotope tracers have been invaluable assets in physiological research for over 80 years. The application of substrate‐specific stable isotope tracers has permitted exquisite insight into amino acid, fatty‐acid and carbohydrate metabolic regulation (i.e. incorporation, flux, and oxidation, in a tissue‐specific and whole‐body fashion) in health, disease and response to acute and chronic exercise. Yet, despite many breakthroughs, there are limitations to ‘substrate‐specific’ stable isotope tracers, which limit physiological insight, e.g. the need for intravenous infusions and restriction to short‐term studies (hours) in controlled laboratory settings. In recent years significant interest has developed in alternative stable isotope tracer techniques that overcome these limitations, in particular deuterium oxide (D2O or heavy water). The unique properties of this tracer mean that through oral administration, the turnover and flux through a number of different substrates (muscle proteins, lipids, glucose, DNA (satellite cells)) can be monitored simultaneously and flexibly (hours/weeks/months) without the need for restrictive experimental control. This makes it uniquely suited for the study of ‘real world’ human exercise physiology (amongst many other applications). Moreover, using D2O permits evaluation of turnover of plasma and muscle proteins (e.g. dynamic proteomics) in addition to metabolomics (e.g. fluxomics) to seek molecular underpinnings, e.g. of exercise adaptation. Here, we provide insight into the role of stable isotope tracers, from substrate‐specific to novel D2O approaches, in facilitating our understanding of metabolism. Further novel potential applications of stable isotope tracers are also discussed in the context of integration with the snowballing field of ‘omic’ technologies.
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Complete Genome Sequence of a GII.17 Norovirus Isolated from a Rhesus Monkey in China
Authors: Liu Bo , Tao Yufen , Li Chao , Li Xintong , Liu Jiansheng , He Zhanlong , Xia Ming , Jiang Xi , Tan Ming , Liu Hongqi 
Published: September 2016

ABSTRACT
The previously silent GII.17 norovirus was found to be the predominant genotype causing major epidemics in China in the 2014–2015 winter epidemic season. We report here the complete genomic sequence of a GII.17 norovirus (mky/GII.17/KM1509/CHN/2015) that infected rhesus monkeys at a monkey farm in southwestern China.
Complete Genome Sequence of Clostridium septicum Strain CSUR P1044, Isolated from the Human Gut Microbiota
Authors: Benamar Samia , Cassir Nadim , Caputo Aurélia , Cadoret Frédéric , La Scola Bernard 
Published: September 2016

ABSTRACT

Clostridium septicum
is one of the first pathogenic anaerobes to be identified. Here, we announce the genome draft sequence of
C. septicum
strain CSUR P1044 isolated from the gut of a healthy adult. Its chromosome genome consists of 3.2 Mbp with a plasmid of 32 Kbp.
C. septicum
strain CSUR P1044 has a G+C content of 27.5%, and is composed of 3,125 protein-coding genes together with 103 RNA genes, including 22 rRNA genes.
Complete Genome Sequence of Two Rift Valley Fever Virus Strains Isolated from Outbreaks in Saudi Arabia (2000) and Kenya (2006 to 2007)
Authors: Shivanna Vinay , McDowell Chester , Wilson William C. , Richt Juergen A. 
Published: September 2016

ABSTRACT
The complete genome sequence, including the untranslated regions, of two Rift Valley fever virus (RVFV) strains isolated from mosquitoes that were collected from disease outbreaks in Saudi Arabia (2001) and Kenya (2006 to 2007) were sequenced using next-generation sequencing technology.
Draft Genome Sequence of Helicobacter suis Strain SNTW101, Isolated from a Japanese Patient with Nodular Gastritis
Authors: Matsui Hidenori , Takahashi Tetsufumi , Murayama Somay Y. , Uchiyama Ikuo , Yamaguchi Katsushi , Shigenobu Shuji , Suzuki Masato , Rimbara Emiko , Shibayama Keigo , Øverby Anders , Nakamura Masahiko 
Published: September 2016

ABSTRACT

We present here the draft whole-genome shotgun sequence of an uncultivated strain SNTW101 of
Helicobacter suis
, which has been maintained in the stomachs of mice. This strain was originally isolated from gastric biopsy specimens of a urea breath test-negative Japanese patient suffering from nodular gastritis.
Draft Genome Sequences of Three Northern German Epidemic Staphylococcus aureus (ST247) Strains Containing Multiple Copies of IS
256
Authors: Kleinert Franziska , Kallies René , Zweynert Annegret , Bierbaum Gabriele 
Published: September 2016

ABSTRACT

We report the draft genome sequences of three multiresistant
Staphylococcus aureus
strains of sequence type 247 (ST247). The methicillin-resistant
S. aureus
(MRSA) SA1450/94 is vancomycin susceptible, while the clinical MRSA isolate
S. aureus
SA137/93A and its spontaneous laboratory mutant SA137/93G are characterized by intermediate vancomycin susceptibility.
Draft Genome Sequence of Uropathogenic Escherichia coli Strain NB8
Authors: Weng Xing-bei , Mi Zu-huang , Wang Chun-xin , Zhu Jian-ming 
Published: September 2016

ABSTRACT

Escherichia coli
NB8 is a clinical pyelonephritis isolate. Here, we report the draft genome sequence of uropathogenic
E. coli
NB8, which contains drug resistance genes encoding resistance to beta-lactams, aminoglycosides, quinolones, macrolides, colistin, sulfonamide-trimethoprim, and tetracycline. NB8 infects the kidney and bladder, making it an important tool for studying
E. coli
pathogenesis.
Complete Genome Sequence of the Attenuated Corynebacterium pseudotuberculosis Strain T1
Authors: Almeida Sintia , Loureiro Dan , Portela Ricardo W. , Mariano Diego C. B. , Sousa Thiago J. , Pereira Felipe L. , Dorella Fernanda A. , Carvalho Alex F. , Moura-Costa Lilia F. , Leal Carlos A. G. , Figueiredo Henrique C. , Meyer Roberto , Azevedo Vasco 
Published: September 2016

ABSTRACT

We present here the genome sequence of the attenuated
Corynebacterium pseudotuberculosis
strain T1. The sequencing was performed with an Ion Torrent Personal Genome Machine platform. The genome is a circular chromosome of 2,337,201 bp, with a G+C content of 52.85% and a total of 2,125 coding sequences (CDSs), 12 rRNAs, 49 tRNAs, and 24 pseudogenes.
Draft Genome Sequence of Salmonella enterica subsp.
enterica
Serovar Blockley Strain CRJJGF_00147 (Phylum
Gammaproteobacteria
)
Authors: Gupta Sushim K. , McMillan Elizabeth A. , Jackson Charlene R. , Desai Prerak T. , Porwollik Steffen , McClelland Michael , Hiott Lari M. , Humayoun Shaheen B. , Frye Jonathan G. 
Published: September 2016

ABSTRACT

Here, we report a 4.72-Mbp draft genome sequence of
Salmonella enterica
subsp.
enterica
serovar Blockley strain CRJJGF_00147, isolated from chicken rinse in 2009.
Prevalence of obesity and affecting factors in physically disabled adults living in the city centre of Malatya
Authors: Bozkir Çiğdem , Özer Ali , Pehlivan Erkan 
Published: September 2016

ObjectiveThe purpose of this study was to investigate the prevalence of obesity, and the risk factors associated with it, in physically disabled adults living in the city centre of Malatya, Turkey.MethodThis research was designed as a cross-sectional study conducted on physically disabled people aged 20–65 years living in the city centre of Malatya. The prevalence of obesity in disabled people was within 95% CIs, the power was calculated as 80%, and the sample size of our population was calculated as 258 individuals.ResultsThe prevalence of obesity was found to be 13.2%. The relationship between disability type and obesity status was found to be significant. The prevalence of obesity was 21.3% in visually impaired people, 17.9% in speech-impaired people, 17.8% in hearing-impaired people and 6.5% in orthopaedically disabled people.ConclusionsEducational interventions on nutrition and lifestyle can be effective considering the high prevalence of obesity in visually impaired people, the prevalence of weakness in orthopaedically disabled people and the risk related to the area in which body fat is localised even when body mass index is within the normal range. Training disabled people in sports appropriate to their disability type and building appropriate facilities for those sports might have a positive effect.