bluuebunny/crossref_metadata_2025_split huggingface dataset:
A serum 6-miRNA panel as a novel non-invasive biomarker for meningioma
Authors: Zhi Feng , Shao Naiyuan , Li Bowen , Xue Lian , Deng Danni , Xu Yuan , Lan Qing , Peng Ya , Yang Yilin 
Published: August 2016

AbstractCirculating microRNAs (miRNAs) hold great promise as novel clinically blood-based biomarkers for cancer diagnosis and prognosis. However, little is known about their impact in meningioma. The TLDA assay was performed as an initial survey to determine the serum miRNA expression profile in two pooled samples from 20 pre-operative meningiomas and 20 matched healthy controls. Selected candidate miRNAs were subsequently validated individually in another 210 patients and 210 healthy controls from two independent cohorts by qRT-PCR. The serum levels of miR-106a-5p, miR-219-5p, miR-375 and miR-409-3p were significantly increased, whereas the serum levels of miR-197 and miR-224 were markedly decreased. The area under the ROC curve (AUC) for the six combined miRNAs was 0.778. The 4 increased miRNAs were significantly decreased, while the 2 decreased miRNAs were significantly increased after tumor removal. Furthermore, the expression levels of miR-224 were associated with sex and the expression levels of miR-219-5p were positively associated with the clinical stages of meningioma. Finally, the high expression of miR-409-3p and low expression of miR-224 were significantly correlated with higher recurrence rates. The present study revealed that the panel of 6 serum miRNA may have the potential to be used clinically as an auxiliary tool for meningioma patients.
The lightest organic radical cation for charge storage in redox flow batteries
Authors: Huang Jinhua , Pan Baofei , Duan Wentao , Wei Xiaoliang , Assary Rajeev S. , Su Liang , Brushett Fikile R. , Cheng Lei , Liao Chen , Ferrandon Magali S. , Wang Wei , Zhang Zhengcheng , Burrell Anthony K. , Curtiss Larry A. , Shkrob Ilya A. , Moore Jeffrey S. , Zhang Lu 
Published: August 2016

AbstractIn advanced electrical grids of the future, electrochemically rechargeable fluids of high energy density will capture the power generated from intermittent sources like solar and wind. To meet this outstanding technological demand there is a need to understand the fundamental limits and interplay of electrochemical potential, stability, and solubility in low-weight redox-active molecules. By generating a combinatorial set of 1,4-dimethoxybenzene derivatives with different arrangements of substituents, we discovered a minimalistic structure that combines exceptional long-term stability in its oxidized form and a record-breaking intrinsic capacity of 161 mAh/g. The nonaqueous redox flow battery has been demonstrated that uses this molecule as a catholyte material and operated stably for 100 charge/discharge cycles. The observed stability trends are rationalized by mechanistic considerations of the reaction pathways.
Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis
Authors: Li Ling , Qu Ye , Jin Xin , Guo Xiao Qin , Wang Yue , Qi Lin , Yang Jing , Zhang Peng , Li Ling Zhi 
Published: August 2016

AbstractHypoxia-inducible factor (HIF)-1α plays a critical role in coupling angiogenesis with osteogenesis during bone development and regeneration. Salidroside (SAL) has shown anti-hypoxic effects in vitro and in vivo. However, the possible roles of SAL in the prevention of hypoxia-induced osteoporosis have remained unknown. Two osteoblast cell lines, MG-63 and ROB, were employed to evaluate the effects of SAL on cell viability, apoptosis, differentiation and mineralization in vitro. Rats subjected to ovariectomy-induced bone loss were treated with SAL in vivo. Our results showed that pre-treatment with SAL markedly attenuated the hypoxia-induced reductions in cell viability, apoptosis, differentiation and mineralization. SAL down-regulated HIF-1α expression and inhibited its translocation; however, SAL increased its transcriptional activity and, consequently, up-regulated vascular endothelial growth factor (VEGF). In vivo studies further demonstrated that SAL caused decreases in the mineral, alkaline phosphatase (ALP) and BGP concentrations in the blood of ovariectomized (OVX) rats. Moreover, SAL improved the trabecular bone microarchitecture and increased bone mineral density in the distal femur. Additionally, SAL administration partially ameliorated this hypoxia via the HIF-1α-VEGF signalling pathway. Our results indicate that SAL prevents bone loss by enhancing angiogenesis and osteogenesis and that these effects are associated with the activation of HIF-1α signalling.
Taxonomy and physiological characterisation of Scheffersomyces titanus sp. nov., a new D-xylose-fermenting yeast species from China
Authors: Liu Xiao-Jing , Cao Wan-Nan , Ren Yong-Cheng , Xu Long-Long , Yi Ze-Hao , Liu Zheng , Hui Feng-Li 
Published: August 2016

AbstractThree strains of a d-xylose-fermenting yeast species were isolated from the host beetle Dorcus titanus collected from two different localities in Henan Province, Central China. These strains formed two hat-shaped ascospores in conjugated and deliquescent asci. Multilocus phylogenetic analysis that included the nearly complete small subunit (SSU), the internal transcribed spacer (ITS) region and the D1/D2 domains of the large subunit (LSU) rDNAs, as well as RNA polymerase II largest subunit (RPB1) gene demonstrated that these strains represent a novel yeast species belonging to the genus Scheffersomyces. The phylogenetic analysis based on the nucleotide sequences of the xylose reductase (XYL1) gene supported the view that the new strains could be grouped as a unique species. Although this new species is highly similar to Scheffersomyces stipitis-like yeasts in terms of nrDNA sequences and morphological and physiological characteristics, the species can be clearly differentiated from its close relatives on the basis of the sequences of XYL1 and RPB1. Therefore, a novel yeast species, Scheffersomyces titanus sp. nov., is proposed to accommodate these strains. The type strain is NYNU 14712T (CICC 33061T = CBS 13926T).
Nonlinear deformation and localized failure of bacterial streamers in creeping flows
Authors: Biswas Ishita , Ghosh Ranajay , Sadrzadeh Mohtada , Kumar Aloke 
Published: August 2016

AbstractWe investigate the failure of bacterial floc mediated streamers in a microfluidic device in a creeping flow regime using both experimental observations and analytical modeling. The quantification of streamer deformation and failure behavior is possible due to the use of 200 nm fluorescent polystyrene beads which firmly embed in the extracellular polymeric substance (EPS) and act as tracers. The streamers, which form soon after the commencement of flow begin to deviate from an apparently quiescent fully formed state in spite of steady background flow and limited mass accretion indicating significant mechanical nonlinearity. This nonlinear behavior shows distinct phases of deformation with mutually different characteristic times and comes to an end with a distinct localized failure of the streamer far from the walls. We investigate this deformation and failure behavior for two separate bacterial strains and develop a simplified but nonlinear analytical model describing the experimentally observed instability phenomena assuming a necking route to instability. Our model leads to a power law relation between the critical strain at failure and the fluid velocity scale exhibiting excellent qualitative and quantitative agreeing with the experimental rupture behavior.
Invasion of moso bamboo into a Japanese cedar plantation affects the chemical composition and humification of soil organic matter
Authors: Wang Hsueh-Ching , Tian Guanglong , Chiu Chih-Yu 
Published: August 2016

AbstractBamboo, which has dense culms and root rhizome systems, can alter soil properties when it invades adjacent forests. Therefore, this study investigated whether bamboo invasions can cause changes in soil organic matter (SOM) composition and soil humification. We combined solid-state 13C NMR spectroscopy and chemical analysis to examine the SOM in a Japanese cedar (Cryptomeria japonica) and adjacent bamboo (Phyllostachys edulis) plantation. Bamboo reduced soil organic C (SOC) content, compared to the cedar plantation. The value of ∆logK (ratio of absorbance of humic acids at 400 and 600 nm) was cedar > transition zone > bamboo soils. Our results indicated that bamboo increased SOM humification, which could be due to the fast decomposition of bamboo litter with the high labile C. Furthermore, intensive management in the bamboo plantation could enhance the humification as well. Overall, litter type can control an ecosystem’s SOC nature, as reflected by the finding that higher labile C in bamboo litter contributed the higher ratios of labile C to SOC and lower ratios of recalcitrant C to SOC in bamboo soils compared with cedar soils. The invasion of bamboo into the Japanese cedar plantation accelerated the degradation of SOM.
The interplay of crack hopping, delamination and interface failure in drying nanoparticle films
Authors: Yang Bin , Sharp James S. , Smith Mike I. 
Published: August 2016

AbstractFilms formed through the drying of nanoparticle suspensions release the build-up of strain through a variety of different mechanisms including shear banding, crack formation and delamination. Here we show that important connections exist between these different phenomena: delamination depends on the dynamics of crack hopping, which in turn is influenced by the presence of shear bands. We also show that delamination does not occur uniformly across the film. As cracks hop they locally initiate the delamination of the film which warps with a timescale much longer than that associated with the hopping of cracks. The motion of a small region of the delamination front, where the shear component of interfacial crack propagation is believed to be enhanced, results in the deposition of a complex zig-zag pattern on the supporting substrate.
Coherent control of long-range photoinduced electron transfer by stimulated X-ray Raman processes
Authors: Dorfman Konstantin E. , Zhang Yu , Mukamel Shaul 
Published: August 2016

SignificanceElectron transfer is ubiquitous in chemical reactions and many biophysical processes such as respiration and photosynthesis. In this work, we show how broadband X-ray pulses can be used to change the local electronic structures of donor–bridge–acceptor (DBA) molecular systems, thus enabling and controlling electron transfer between designated sites in the molecule. An X-ray–stimulated Raman process can control electron transfer with atomic specificity and ultrafast timescale. With an appropriate X-ray pulse setting, electron pathways can be selectively enhanced. The control can be implemented at the donor, bridge, or acceptor sites in a DBA system.
Proteomics of Physcomitrella patens protonemata subjected to treatment with 12-oxo-phytodienoic acid
Authors: Luo Weifeng , Nanjo Yohei , Komatsu Setsuko , Matsuura Hideyuki , Takahashi Kosaku 
Published: August 2016

Abstract
12-Oxo-phytodienoic acid (OPDA) is induced by mechanical wounding and suppresses the growth of Physcomitrella patens; OPDA is considered as a signal compound in this moss species. In this study, a proteomic analysis of P. patens protonemata treated with OPDA was performed. The abundance levels of 41 proteins were significantly altered by OPDA, with decreased levels for 40 proteins. The proteins for which abundance decreased in response to OPDA at the protonema developmental stage were mainly involved in the metabolism of proteins and carbohydrates. The effects of inhibition on protein abundance are likely a major physiological function of OPDA in P. patens. OPDA also suppressed the expression of histones at the protein level and gene transcription level. Suppression of histone expression might be an OPDA-specific function in P. patens protonemata. In P. patens, a subset of the physiological responses caused by OPDA is shown to differ between protonema and gametophore developmental stages.
The frequency of inappropriate nonformulary medication alert overrides in the inpatient setting
Authors: Her Qoua L , Amato Mary G , Seger Diane L , Beeler Patrick E , Slight Sarah P , Dalleur Olivia , Dykes Patricia C , Gilmore James F , Fanikos John , Fiskio Julie M , Bates David W 
Published: August 2016

Abstract
Background Experts suggest that formulary alerts at the time of medication order entry are the most effective form of clinical decision support to automate formulary management.
Objective Our objectives were to quantify the frequency of inappropriate nonformulary medication (NFM) alert overrides in the inpatient setting and provide insight on how the design of formulary alerts could be improved.
Methods Alert overrides of the top 11 ( n  = 206) most-utilized and highest-costing NFMs, from January 1 to December 31, 2012, were randomly selected for appropriateness evaluation. Using an empirically developed appropriateness algorithm, appropriateness of NFM alert overrides was assessed by 2 pharmacists via chart review. Appropriateness agreement of overrides was assessed with a Cohen’s kappa. We also assessed which types of NFMs were most likely to be inappropriately overridden, the override reasons that were disproportionately provided in the inappropriate overrides, and the specific reasons the overrides were considered inappropriate.
Results Approximately 17.2% ( n  = 35.4/206) of NFM alerts were inappropriately overridden. Non-oral NFM alerts were more likely to be inappropriately overridden compared to orals. Alerts overridden with “blank” reasons were more likely to be inappropriate. The failure to first try a formulary alternative was the most common reason for alerts being overridden inappropriately.
Conclusion Approximately 1 in 5 NFM alert overrides are overridden inappropriately. Future research should evaluate the impact of mandating a valid override reason and adding a list of formulary alternatives to each NFM alert; we speculate these NFM alert features may decrease the frequency of inappropriate overrides.
Subdermal Radiofrequency for Skin Tightening of the Posterior Upper Arms
Authors: Wu Douglas C. , Liolios Anamarie , Mahoney Leysin , Guiha Isabella , Goldman Mitchel P. 
Published: August 2016

BACKGROUND
Subsurface thermistor-controlled monopolar radiofrequency (SMRF) is an emerging technology designed to offer a minimally invasive option for tightening of lax skin. The versatility of this technique allows it to be applied to virtually any body site.

OBJECTIVE
The purpose of this study is to evaluate the safety and efficacy of SMRF for tightening of posterior upper arm skin laxity.

PATIENTS
This is a prospective, open-label clinical trial involving 12 subjects aged 18 to 65 with moderate-to-severe skin laxity in the posterior upper arms.

METHODS/MATERIALS
Each subject received treatment to the bilateral arms resulting in a population of n = 24 arms in the analysis group. Treatment consisted of SMRF delivered at Day 0 of the trial. Follow-up evaluation was conducted at Day 7, 30, and 90 post-treatment. The primary end point was the assessment of skin laxity by a nontreating physician utilizing a standardized 5 point Skin Laxity Grading Scale at baseline, Days 30 and 90. Subject self-evaluation of firmness, laxity, texture, and satisfaction was also collected. Circumferential and vertical arm measurements were obtained via digital fractional caliper. An adverse event profile was categorized.

RESULTS
Significant improvements in skin laxity were observed at both Day 30 and at Day 90 post-treatment as assessed by the nontreating investigator. Subjects also rated significant improvements in the firmness, texture, and laxity of their treated arms. The majority of subjects were “satisfied” to “extremely satisfied” with their results. Adverse events recorded at Day 7 post-treatment included erythema (4%), contour irregularity (4%), and bruising (13%). All adverse events resolved completely by Day 30 post-treatment.

CONCLUSION
Thermistor-controlled SMRF is a safe and effective means to treating posterior upper arm skin laxity.
A Randomized Clinical Trial of Comparing Monophasic Monodensified and Biphasic Nonanimal Stabilized Hyaluronic Acid Dermal Fillers in Treatment of Asian Nasolabial Folds
Authors: Zhou Shuang-Bai , Xie Yun , Chiang Cheng-An , Liu Kai , Li Qing-Feng 
Published: August 2016

BACKGROUNDCross-linked hyaluronic acids (HAs) with varying characteristics and formulations are available. Despite the popularity of HA, limited studies compared the effectiveness of monophasic monodensified hyaluronic acid (MMHA) and biphasic nonanimal stabilized hyaluronic acid (BHA) products in correcting nasolabial folds (NLFs) in the Asian population.OBJECTIVEThis double-blinded, randomized research aimed at evaluating the outcomes of MMHA and BHA products in treating Asian NLFs.MATERIALS AND METHODSSubjects aged between 18 and 65 years with moderate-to-severe NLFs were randomized to receive MMHA or BHA treatment. A touch-up treatment with the same product was performed at the 4-week follow-up, if needed. The effectiveness was evaluated for 24 weeks by masked investigators. All adverse events were recorded for safety evaluation.RESULTSTwenty-five subjects in the MMHA Group and twenty-four subjects in the BHA Group finished 24-week follow-up. Results showed that subjects from both groups obtained satisfactory outcome in NLF correction. A lower amount of MMHA was required to achieve a similar result as that of BHA (p< .01). Both HA products maintained the effectiveness at the end of the 24-week follow-up.CONCLUSIONBoth MMHA and BHA are effective for correcting NLF in Asian patients, producing satisfactory results. Monophasic monodensified hyaluronic acid provides similar satisfaction to BHA while requiring less injection volume.
Droxidopa in the Treatment of Postural Orthostatic Tachycardia Syndrome
Authors: Ruzieh Mohammed , Dasa Osama , Pacenta Ann , Karabin Beverly , Grubb Blair 
Published: August 2016

Background:
Postural orthostatic tachycardia syndrome (POTS) is a constellation of signs and symptoms that occur when a patient is upright and relieved by recumbence. Currently, no drugs are labeled for the treatment for POTS. Droxidopa is an orally administered amino acid that is converted to norepinephrine and thought to improve both blood pressure and symptoms in patients with orthostatic intolerance.

Study Question:
To appraise the effect of Droxidopa in a clinical setting in patients with POTS refractory to other forms of treatment.

Study Design:
A retrospective study of patients with POTS at our Syncope and Autonomic Disorders Center. Three hundred fifty-two patients were screened, 54 of them were prescribed Droxidopa and found to be eligible to include in our study.

Measures and Outcome:
Symptoms of orthostatic intolerance, side effects of therapy and response to treatment. Statistical analyses were done using SPSS software. Thirty-seven patients were included in data analysis. Patients who failed to follow up, didn't obtain Droxidopa due to insurance and cost concerns, had hypertensive response to therapy or had allergic reaction were excluded from data analysis.

Results:
The most frequently reported symptom was dizziness in 91.9% of patients, followed by syncope and fatigue in 70.3% and 67.6% of patients, respectively. Symptoms of dizziness, syncope and fatigue were reported less after treatment; 75.7%, 51.4% and 40.5%, respectively. There was no statistically significant difference in standing or sitting blood pressure before and after treatment. Despite the improvement in some symptoms. Only 27% of patients reported improved quality of life after treatment. Of total, 40.5% of patients stopped the treatment either due to side effects or ineffectiveness.

Conclusion:
Droxidopa appears to improve some symptoms of orthostatic intolerance in patients with POTS but has diminutive impact on quality of life and blood pressure. Further assessment in large clinical trials is needed to evaluate its efficacy.
Atypical Presentation of Chorioretinal Folds-Related Maculopathy
Authors: Corvi Federico , Capuano Vittorio , Benatti Lucia , Bandello Francesco , Souied Eric , Querques Giuseppe 
Published: August 2016

ABSTRACT

Purpose
Chorioretinal folds are undulations that anatomically include the inner choroid, Bruch’s membrane, and the retinal pigment epithelium, and secondarily affect the overlying neurosensory retina. We analyzed clinical data and management of six patients diagnosed with chorioretinal folds-related maculopathy with atypical presentations.

Case Report
The mean age of the six patients (five women) was 77 years. Best-corrected visual acuity (BCVA) ranged between 20/200 and 20/80. None of the patients had history of hypertension, cardiovascular diseases, or autoimmune disease, and they were all diagnosed with idiopathic chorioretinal folds. Case 1, 2, and 3 received intravitreal antivascular endothelial growth factor (VEGF) therapy; case 4 received intravitreal anti-VEGF and photodynamic therapy; case 5 received only photodynamic therapy; and case 6 received intravitreal injections of sustained-release dexamethasone implant (Ozurdex). In case 1 and 2, the use of ranibizumab resulted in BCVA improvement and resolution of sub-/intraretinal exudation. In case 3, ranibizumab led to a mild reduction of the intraretinal exudation but no changes in BCVA. In case 4 and 5, six intravitreal injections of ranibizumab with two photodynamic therapies and three photodynamic therapies, respectively, led to a mild reduction of the sub-/intraretinal exudation but no changes in BCVA. In case 6, five intravitreal injections of Ozurdex in both eyes led to reduction of the subretinal or intraretinal fluid accumulation and BCVA improvement.

Discussion
Choroidal vessel dilation and hyperpermeability may be involved in atypical presentations of chorioretinal folds-related maculopathy characterized by sub-/intraretinal fluid accumulation. Dilated and hyperpermeable choroidal vessels may result in focal retinal pigment epithelium alterations that can progress to choroidal neovascularization or chronic central serous chorioretinopathy-like maculopathy with or without telangiectatic retinal capillaries. Intravitreal anti-VEGF administration seems effective to treat choroidal neovascularization in stage 3 chorioretinal folds-related maculopathy, both anti-VEGF and photodynamic therapy seem to have only limited efficacy on chronic central serous chorioretinopathy-like maculopathy (and telangiectatic retinal capillaries), whereas intravitreal injection of Ozurdex seems efficacious to treat chronic central serous chorioretinopathy-like maculopathy.