bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anesthetic Efficacy of Clove Oil, Propofol, 2‐Phenoxyethanol, and Ketamine Hydrochloride on Persian Sturgeon, Acipenser persicus, Juveniles
Authors: Adel Milad , Sadegh Amin Bigham , Yeganeh Sakineh , Movafagh Ahmad Nosrati , Saoud I. Patrick 
Published: April 2016

AbstractAnesthetics are commonly used in the aquaculture industry to reduce stress and prevent mortality of fish during transportation, handling, and surgical procedures. This study assessed the efficacy of four anesthetic agents (clove oil, propofol, 2‐phenoxyethanol [2‐PE], and ketamine hydrochloride) on Persian sturgeon, Acipenser persicus, juveniles. In addition, results of the first experiment were used to evaluate sedation concentrations suitable for transportation of Persian sturgeon. The concentrations of anesthetics or sedatives evaluated in the first experiment were: 25, 50, 75, and 100 mg/L for clove oil; 1, 1.25, 2.5, and 5 mg/L for propofol; 110, 330, 550, and 770 mg/L for 2‐PE; and 1250, 2500, 3750, and 5000 mg/L for ketamine hydrochloride. Results show significant reduction in time to anesthesia and significant increase in recovery time with increase in concentration of all anesthetics. The most clinically useful concentrations of anesthetics tested were between 25 and 50 mg/L for clove oil, less than 1 mg/L for propofol, 330 mg/L for 2‐PE, and none of the tested concentrations for ketamine hydrochloride. In the second experiment, juveniles were placed in low concentrations of anesthetic solutions for 24 h and survival assessed. The four anesthetics tested are suitable for light sedation during transportation of A. persicus juveniles. Results are helpful to scientists working with Persian sturgeon aquaculture and restocking programs.
Disruption of OsSULTR3;3 reduces phytate and phosphorus concentrations and alters the metabolite profile in rice grains
Authors: Zhao Haijun , Frank Thomas , Tan Yuanyuan , Zhou Chenguang , Jabnoune Mehdi , Arpat A. Bulak , Cui Hairui , Huang Jianzhong , He Zuhua , Poirier Yves , Engel Karl‐Heinz , Shu Qingyao 
Published: April 2016

Summary

Two low phytic acid (lpa) mutants have been developed previously with the aim to improve the nutritional value of rice (Oryza sativa) grains. In the present study, the impacts of lpa mutations on grain composition and underlying molecular mechanisms were investigated.

Comparative compositional analyses and metabolite profiling demonstrated that concentrations of both phytic acid (PA) and total phosphorus (P) were significantly reduced in lpa brown rice, accompanied by changes in other metabolites and increased concentrations of nutritionally relevant compounds. The lpa mutations modified the expression of a number of genes involved in PA metabolism, as well as in sulfate and phosphate homeostasis and metabolism.

Map‐based cloning and complementation identified the underlying lpa gene to be OsSULTR3;3. The promoter of OsSULTR3;3 is highly active in the vascular bundles of leaves, stems and seeds, and its protein is localized in the endoplasmic reticulum. No activity of OsSULTR3;3 was revealed for the transport of phosphate, sulfate, inositol or inositol 1,4,5 triphosphate by heterologous expression in either yeast or Xenopus oocytes.

The findings reveal that OsSULTR3;3 plays an important role in grain metabolism, pointing to a new route to generate value‐added grains in rice and other cereal crops.
The impact of antiretroviral therapy in resource‐limited settings and current HIV therapeutics
Authors: Kumarasamy N 
Published: April 2016

Four million people of the global total of 35 million with HIV infection are from South‐East Asia. ART is currently utilized by 15 million people and has led to a dramatic decline in the mortality rate, including those in low‐ and middle‐income countries. A reduction in sexually transmitted HIV and in comorbidities including tuberculosis has also followed. Current recommendations for the initiation of antiretroviral therapy in people who are HIV+ are essentially to initiate ART irrespective of CD4 cell count and clinical stage. The frequency of HIV testing should be culturally specific and based on the HIV incidence in different key populations but phasing in viral load technology in LMIC is an urgent priority and this needs resources and capacity. With the availability of simplified potent ART regimens, persons with HIV now live longer. The recent WHO treatment guidelines recommending routine HIV testing and earlier initiation of treatment should be the stepping stone for ending the AIDS epidemic and to meet the UNAIDS mission of 90*90*90.
Osmotic potential at full turgor: an easily measurable trait to help breeders select for drought tolerance in wheat
Authors: Mart Kyle B. , Veneklaas Erik J. , Bramley Helen 
Published: April 2016

AbstractThis study investigated the relationship between osmotic potential at full hydration (π100) and turgor loss point (ΨTLP) in wheat (Triticum aestivum) to determine the potential of using π100 to predict ΨTLP under well‐watered (WW) and drought (WS) conditions. Two methods for determining π100 were tested: pressure–volume (PV) analysis and freezing point osmometry. The study also measured π100 in a range of 38 field‐grown wheat cultivars to determine whether there is genetic variation in π100 under field conditions. π100 correlated with ΨTLP using both methods under both water treatments, particularly WS. Genetic variation of π100 in the field, under rainfed conditions, was greater than controlled conditions and ranged from −0.94 to −1.95 MPa. Overall, the evidence supports development of π100 as a novel tool for plant breeders to screen large populations of wheat and identify genotypes with lower ΨTLP, an integrative trait that is related to drought tolerance.
The medical licensing examination debate
Authors: Archer Julian , Lynn Nick , Coombes Lee , Roberts Martin , Gale Tom , Regan de Bere Sam 
Published: April 2016

AbstractNational licensing examinations are typically large‐scale examinations taken early in a career or near the point of graduation, and, importantly, success is required to subsequently be able to practice. They are becoming increasingly popular as a method of quality assurance in the medical workforce, but debate about their contribution to patient safety and the improvement of healthcare outcomes continues.A systematic review of the national licensing examination literature demonstrates that there is disagreement between assessment experts about the strengths and challenges of licensing examinations. This is characterized by a trans‐Atlantic divide between the dominance of psychometric reliability assurance in North America and the wider interpretations of validity, to include consequences, in Europe. We conclude that the debate might benefit from refocusing to what a national licensing examination should assess: to achieve a balance between assessing a breadth of skills and the capacity for such skills in practice, and focusing less on reproducibility.
Does Real Estate Defy Gravity? An Analysis of Foreign Real Estate Investment Flows
Authors: McAllister Pat , Nanda Anupam 
Published: April 2016

AbstractThis paper investigates the scale and determinants of foreign investment flows between national real estate markets. Using data for over 100 countries over 2007–2012, the results indicate that, consistent with previous studies for trade, foreign direct and portfolio investment variables such as size and distance have significant effects on foreign real estate investment flows. Large positive size effects are consistent with a combination of scale economies and information externalities producing investment concentration across markets and in conjunction with direct and indirect transaction costs specific to real estate markets. Physical distance coefficients are relatively small compared to the studies of FDI.
Is A Person Thinking About Suicide Likely to Find Help on the Internet? An Evaluation of Google Search Results
Authors: Thornton Louise , Handley Tonelle , Kay‐Lambkin Frances , Baker Amanda 
Published: April 2016

It is unclear whether individuals searching the Internet for assistance with thoughts of suicide are likely to encounter predominantly helpful or harmful resources. This study investigated websites retrieved by searching Google for information and support for suicidal thoughts. Google searches retrieved a high percentage of irrelevant websites (26%, n = 136). Of the 329 relevant websites retrieved, the majority were suicide preventive (68%); however, a considerable proportion of sites expressed mixed (22%) or neutral (8%) suicide attitudes, and 1% were explicitly pro‐suicide. The results highlight a need for suicide prevention organization websites to be made more easily accessible. In the meantime, clinicians should be aware of appropriate websites to recommend to clients.
Cutaneous form of maculopapular mastocytosis in a foal
Authors: Junginger Johannes , Geburek Florian , Khan Muhammad Akram , Müller Gundi , Gruber Achim D. , Hewicker‐Trautwein Marion 
Published: April 2016

BackgroundCutaneous mastocytosis is a rare benign disease occurring in domestic animals and humans. In previous reports, dermal findings in foals were accompanied by systemic mast cell infiltrations, whereas lesions in human cutaneous mastocytosis, including urticaria pigmentosa and solitary mastocytoma, are usually restricted to the skin.ObjectivesTo describe a new variant of equine cutaneous maculopapular mastocytosis lacking systemic involvement.AnimalsA 2.5‐month‐old warmblood foal with multiple skin nodules since birth.MethodsClinical examination (including haematology, fine needle biopsy and thoracic radiographs), postmortem examination, histopathology and immunohistochemistry.ResultsClinical examination showed 41 skin nodules that contained numerous mast cells as detected by cytology. Macroscopic examination at postmortem examination revealed intradermal circumscribed lesions ranging from 2 to 5 cm in diameter. Histologically, they were composed of well differentiated mast cells with metachromatic granules stained with toluidine blue accompanied by many eosinophils. Immunohistochemically, mast cells had mast cell growth factor receptor c‐KIT predominating at the cell surface and intracytoplasmic expression of tryptase. In other organs similar mast cell infiltrations were not detected.Conclusions and clinical importanceThe case presented here fulfils the criteria of equine cutaneous maculopapular mastocytosis (ECMM), representing a rare entity in foals that is reported to be associated with spontaneous regression, although the long‐term prognosis is not known. Unlike in previous reports, lesions described here were restricted to the skin. This may imply that ECMM is primarily a dermal disease sharing similarities with urticaria pigmentosa in young children.
Osman Lins - unindo o aqui e o ontem
Authors: Nunes Juçara Marçal 
Published: April 2016

Este exercício de leitura de A Rainha dos Cárceres da Grécia desenvolve algumas possibilidades de significação do modelo de interpretação proposto por José Paulo Paes, um "dispositivo de espelhos conjugados", com o qual ele desvenda o romance de Osman Lins. Análise de Ismail Xavier sobre a produção cultu ral brasileira da década de 1970 é outra referência. A partir dela, será possível perceber os efeitos alcançados por Osman Lins na criação de emblemas que traduzem a realidade do país num momento de crise econômica, política e cultural.
Aproximação de um problema: a ficção do leitor nas tramas de Guimarães Rosa
Authors: Gama Mônica 
Published: April 2016

Este artigo propõe o apontamento de algumas questões relativas à construção da imagem do leitor nas tramas de Guimarães Rosa. Partiremos da percepção de que o texto ficcional é composto por uma série de preorientações para sua recepção e também de que na obra de Guimarães Rosa temos como marca constitutiva a ficção de um leitor no texto. Essa ficção apresenta-se desde Sagarana até Ave, palavra e Estas estórias, livros publicados postumamente. Para entender como se dá essa ficcionalização do leitor, partiremos aqui da análise desse aspecto nos contos “Corpo fechado”, “Desenredo” e “Antiperipléia”, o primeiro de Sagarana e os dois últimos de Tutaméia.
Detection and tracking of overlapping cell nuclei for large scale mitosis analyses
Authors: Li Yingbo , Rose France , di Pietro Florencia , Morin Xavier , Genovesio Auguste 
Published: April 2016

Abstract
Background
Cell culture on printed micropatterns slides combined with automated fluorescent microscopy allows for extraction of tens of thousands of videos of small isolated growing cell clusters. The analysis of such large dataset in space and time is of great interest to the community in order to identify factors involved in cell growth, cell division or tissue formation by testing multiples conditions. However, cells growing on a micropattern tend to be tightly packed and to overlap with each other. Consequently, image analysis of those large dynamic datasets with no possible human intervention has proven impossible using state of the art automated cell detection methods.

Results
Here, we propose a fully automated image analysis approach to estimate the number, the location and the shape of each cell nucleus, in clusters at high throughput. The method is based on a robust fit of Gaussian mixture models with two and three components on each frame followed by an analysis over time of the fitting residual and two other relevant features. We use it to identify with high precision the very first frame containing three cells. This allows in our case to measure a cell division angle on each video and to construct division angle distributions for each tested condition. We demonstrate the accuracy of our method by validating it against manual annotation on about 4000 videos of cell clusters.

Conclusions
The proposed approach enables the high throughput analysis of video sequences of isolated cell clusters obtained using micropatterns. It relies only on two parameters that can be set robustly as they reduce to the average cell size and intensity.
Gründungsurkunde der Griechischen gemeinde in Pest aus dem Jahre 1802
Authors: Füves Ödön 
Published: April 2016

<div class="page" title="Page 349"><div class="layoutArea"><div class="column"><p><span>Κατά τήν κατάταξιν του αρχείου τής έλληνικής κοινότητος τής Πέστης εύρέθη τό ιδρυτικόν έγγραφον αυτής του έτους </span><span>1802, </span><span>τό όποιον δημοσιεύε­ ται ενταύθα. </span></p><p><span>Τό έγγραφον αποτελεί συμφωνίαν των Ελλήνων καί Μακεδονοβλάχων τής πόλεως διά τήν ειρηνικήν των συμβίωσιν, ρυθμίζον τον άριθμόν των ιερέων, τάς μεταξύ των σχέσεις κ.λ. Εισαγωγικά ό συγγραφεύς άναφέρεται εις τάς προ τού 1802 ένεργείας των Ελλήνων τής Πέστης διά τήν ϊδρυσιν ιδιαιτέρας έκκλησίας, ώς καί είς τώς διαφωνίας των μετά των Μακεδονοβλάχων. </span></p></div></div></div>
On the Bézout equation in the ring of periodic
distributions
Authors: Rupp Rudolf , Sasane Amol 
Published: April 2016

Abstract
A corona type theorem is given for the ring D'A(Rd) of periodic distributions in Rd in terms of the
sequence of Fourier coefficients of these distributions,which have at most polynomial growth. It is also shown
that the Bass stable rank and the topological stable rank of D'A(Rd) are both equal to 1.
Effekte einer frühen Sozialisierung von Ferkeln auf das Verhalten, unter anderem auf das Schwanzbeißen
Authors: Patzkéwitsch Dorian , Reese Sven , Erhard Michael , Klein Sandrina 
Published: April 2016

ZusammenfassungZiel dieser Studie war, die Einflüsse einer frühen Sozialisierung von Ferkeln auf das spätere Verhalten, unter anderem auf das Schwanzbeißen, zu zeigen. Material und Methoden: In drei Durchgängen erfolgten Verhaltensbeobachtungen von insgesamt 183 Tieren von der Geburt bis zum Mastende. Zusätzlich wurden das Gesäuge der Muttersauen sowie das Integument und die Schwänze der Masttiere bonitiert. Für die Sozialisierung wurde den vier Ferkelwürfen der Versuchsgruppe (V) ab dem 10. Lebenstag des jüngsten Wurfes zusätzlicher Raum (Arbeitsgang) zur Verfügung gestellt. Die Ferkel der Kontrollgruppe (K) wurden in konventionellen Abferkelbuchten im gleichen Stallabteil gehalten. Nach Umstallung in den Aufzuchtstall wurden die Ferkel in drei Gruppen eingeteilt: Versuchsgruppe (V/V; zwei Würfe aus Gruppe V), Kontrollgruppe (K/K; zwei Würfe aus Gruppe K) und Mischgruppe (V/K; je ein Wurf aus den Gruppen K und V). Ergebnisse: Nach dem Türenöffnen spielten die Tiere der Gruppe V signifikant (p ≤ 0,01) mehr als die der Gruppe K, wobei sie vor allem den zusätzlichen Raum nutzten. Zudem stieg das agonistische Verhalten in Gruppe V an. Am Tag der Umstallung in den Aufzuchtstall zeigte sich in Gruppe V/V signifikant weniger agonistisches Verhalten als in Gruppe K/K. Schwanzbeißen trat auch im Aufzuchtstall auf, jedoch nur in den Durchgängen zwei und drei. Am 100. Masttag hatten in den Gruppen V/V, V/K und K/K noch 58,7%, 51,7% bzw. 43,3% der Tiere intakte Schwanzspitzen. Schweine der Gruppe K/K wiesen signifikant kürzere Schwänze auf als die der anderen beiden Gruppen. Schlussfolgerung und klinische Relevanz: Die frühe Sozialisierung steigerte das Wohlbefinden der Ferkel im Abferkelstall durch Förderung des Spielverhaltens. Geringeres Auftreten von agonistischem Verhalten bei der Umstallung führte zu einer Stressreduktion zu diesem Zeitpunkt. Das Ziel, die Inzidenz des Schwanzbeißens zu verringern, ließ sich nicht zufriedenstellend erreichen. Die Sozialisierung könnte jedoch in Verbindung mit weiteren Maßnahmen zu einer Beeinflussung des Beißverhaltens beitragen.
Emphysematous pyometra secondary to Enterococcus avium infection in a dog
Authors: Cheng Ching-Chang , Wang Hsien-Chi , Lee Wei-Ming , Shyu Ching-Lin , Lin Cheng-Chung , Chen Kuan-Sheng , Chang An-Chi 
Published: April 2016

SummaryA 5-year-old female intact Mastiff dog was presented with a history of vaginal discharge for 1 day. Physical examination revealed a sanguineo- purulent vaginal discharge and systemic inflammatory response syndrome. Abdominal radiographs showed several dilated and gasfilled tubular loops. The differential diagnoses included emphysematous pyometra or small intestinal mechanical ileus. Surgical exploration of the abdomen demonstrated a severely dilated and gas-filled uterus, and emphysematous pyometra was confirmed. The patient’s clinical signs resolved after ovariohysterectomy. Histopathology revealed mild endometrial cystic hyperplasia with infiltration of inflammatory cells in the superficial endometrial epithelia. Enterococcus avium, an α-hemolytic gram-positive coccus, was isolated from the uterus. This paper highlights the radiographic features of emphysematous pyometra and a pathogen that has never been reported to be associated with canine pyometra previously.
O PROJETO DE EXTENSÃO NA EDUCAÇÃO PROFISSIONAL TÉCNICA DE JOVENS E ADULTOS: ESTRATÉGIAS PARA A AÇÃO DOCENTE
Authors: Gomes Maria de Fátima Feitosa Amorim , Santos Maria do Socorro Ferreira dos 
Published: April 2016

<p>Este artigo tem o objetivo relatar o processo de elaboração e condução de projetos de extensão que se configuram como estratégias adotadas para subsidiar o processo ensino aprendizagem dos estudantes. O método utilizado se deu por meio de encontros semanais com alunos bolsistas e voluntários onde ocorreram reuniões de estudo, com discussão de material científico, instrumentos de coleta de dados e visita técnica ao serviço de alimentação da unidade escolar indicada pela secretaria de educação municipal de Marechal Deodoro. Ficou evidente o quanto as ações de extensão têm contribuído para a formação dos alunos, tornando o processo ensino-aprendizagem e, consequentemente, o conhecimento dos critérios legais relativos a segurança do alimento um assunto de domínio simples, que proporcionou o desenvolvimento de uma visão crítica. Tivemos a oportunidade de refletir que a ação docente vai além de conhecimentos teóricos e práticos, mas perpassa pelo âmbito do compartilhar esses conhecimentos, de reconhecer fragilidades e estabelecer um compromisso com a sociedade.</p>
Transferência de Conhecimento Tácito em Empresas de Base Tecnológica
Authors: Mendes Celson Guimarães , Ziviani Fabricio , Ferreira Marta Araújo Tavares 
Published: April 2016

<p>O objetivo deste trabalho é analisar os fatores de transferência do conhecimento tácito em empresas de base tecnológica no estado de Minas Gerais. A proposta de pesquisa foi estruturada a partir do modelo desenvolvido por Lemos (2008). O modelo de pesquisa está estruturado em identificar práticas de transferência do conhecimento tácito, baseada nos fatores idiossincráticos, nos fatores organizacionais, na estrutura organizacional, na estratégia de transferência de conhecimento. Trata-se de um estudo descritivo com abordagem quantitativa. Os dados foram coletados por meio de questionários estruturados do tipo <em>survey</em>, com escala <em>Likert</em> de sete pontos. A pesquisa foi respondida por 242 empregados de 72 empresas. Os dados foram analisados utilizando estatística multivariada. O estudo indica que as empresas de base tecnológica possuem uma estratégia de transferência do conhecimento definida, onde existe a valorização e o reconhecimento em relação à transferência do conhecimento. Com relação ao fator estrutura organizacional a forma mais utilizada para a transferência do conhecimento é a conversa pessoal, telefone e e-mails, o que pode facilitar a transferência do conhecimento tácito, a hierarquia não atua como barreira para a transferência do conhecimento e existe uma rede de relacionamento entre os funcionários das empresas de base tecnológica. </p>
AGES OF MASSIVE GALAXIES AT 0.5 > z > 2.0 FROM 3D-HST REST-FRAME OPTICAL SPECTROSCOPY
Authors: Fumagalli Mattia , Franx Marijn , Dokkum Pieter van , Whitaker Katherine E. , Skelton Rosalind E. , Brammer Gabriel , Nelson Erica , Maseda Michael , Momcheva Ivelina , Kriek Mariska , Labbé Ivo , Lundgren Britt , Rix Hans-Walter 
Published: April 2016

ABSTRACT
We present low-resolution near-infrared stacked spectra from the 3D–HST survey up to z = 2.0 and fit them with commonly used stellar population synthesis models: BC03, FSPS10 (Flexible Stellar Population Synthesis), and FSPS-C3K. The accuracy of the grism redshifts allows the unambiguous detection of many emission and absorption features and thus a first systematic exploration of the rest-frame optical spectra of galaxies up to z = 2. We select massive galaxies (

log
(

M

*

/

M

⊙

)
>
10.8

), we divide them into quiescent and star-forming via a rest-frame color–color technique, and we median-stack the samples in three redshift bins between z = 0.5 and z = 2.0. We find that stellar population models fit the observations well at wavelengths below the 6500 Å rest frame, but show systematic residuals at redder wavelengths. The FSPS-C3K model generally provides the best fits (evaluated with χ
2
red statistics) for quiescent galaxies, while BC03 performs the best for star-forming galaxies. The stellar ages of quiescent galaxies implied by the models, assuming solar metallicity, vary from 4 Gyr at z ∼ 0.75 to 1.5 Gyr at z ∼ 1.75, with an uncertainty of a factor of two caused by the unknown metallicity. On average, the stellar ages are half the age of the universe at these redshifts. We show that the inferred evolution of ages of quiescent galaxies is in agreement with fundamental plane measurements, assuming an 8 Gyr age for local galaxies. For star-forming galaxies, the inferred ages depend strongly on the stellar population model and the shape of the assumed star-formation history.