bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-React: a new structural bioinformatics method for predicting allergen cross-reactivity
Authors: Negi Surendra S , Braun Werner 
Published: December 2016

Abstract
The phenomenon of cross-reactivity between allergenic proteins plays an important role to understand how the immune system recognizes different antigen proteins. Allergen proteins are known to cross-react if their sequence comparison shows a high sequence identity which also implies that the proteins have a similar 3D fold. In such cases, linear sequence alignment methods are frequently used to predict cross-reactivity between allergenic proteins. However, the prediction of cross-reactivity between distantly related allergens continues to be a challenging task. To overcome this problem, we developed a new structure-based computational method, Cross-React, to predict cross-reactivity between allergenic proteins available in the Structural Database of Allergens (SDAP). Our method is based on the hypothesis that we can find surface patches on 3D structures of potential allergens with amino acid compositions similar to an epitope in a known allergen. We applied the Cross-React method to a diverse set of seven allergens, and successfully identified several cross-reactive allergens with high to moderate sequence identity which have also been experimentally shown to cross-react. Based on these findings, we suggest that Cross-React can be used as a predictive tool to assess protein allergenicity and cross-reactivity.
Availability and Implementation: Cross-React is available at: http://curie.utmb.edu/Cross-React.html
Systematic Review and Metaanalysis of Acute Kidney Injury Associated With Concomitant Vancomycin and Piperacillin/Tazobactam
Authors: Hammond Drayton A. , Smith Melanie N. , Li Chenghui , Hayes Sarah M. , Lusardi Katherine , Bookstaver P. Brandon 
Published: December 2016

Abstract
Concomitant vancomycin and piperacillin/tazobactam (PT) may be associated with increased acute kidney injury (AKI) compared to vancomycin without PT. Medline, Cochrane, and Scopus were searched through October 2016 using “vancomycin,” “piperacillin,” “tazobactam,” and “AKI,” “acute renal failure,” or “nephrotoxicity.” A registered meta-analysis (PROSPERO: CRD42016041646) with relevant scenarios was performed. Fourteen observational studies totaling 3549 patients were analyzed. Concomitant vancomycin and PT was associated with AKI in unadjusted odds ratio (OR, 3.12; 95% confidence interval [CI], 2.04–4.78) and in adjusted OR (aOR, 3.11; 95% CI, 1.77–5.47) analyses. Similar findings were seen assessing studies in adults (aOR, 3.15; 95% CI, 1.72–5.76), children (OR, 4.55; 95% CI, 2.71–10.21), and when &lt;50% of patients received care in an intensive care unit (aOR, 3.04; 95% CI, 1.49–6.22) but not ≥50% (aOR, 2.83; 95% CI, 0.74–10.85). Increased AKI with concomitant vancomycin and PT should be considered when determining beta-lactam therapy.
An Employment Guarantee as Risk Insurance? Assessing the Effects of the NREGS on Agricultural Production Decisions
Authors: Gehrke Esther 
Published: December 2016

Abstract
Uninsured risk constrains households in their production decisions in many developing countries. Similarly to crop insurance, employment guarantees can support farmers in managing agricultural production risks. Evidence from representative panel data of Andhra Pradesh, India, suggests that the National Rural Employment Guarantee Scheme (NREGS) reduces households’ uncertainty about future income streams because it provides employment opportunities in rural areas independently of weather shocks and crop failure. Therewith the NREGS makes an ex-post labor supply response to agricultural shocks more efficient. Households with access to the NREGS are found to shift their production toward riskier but also more profitable crops. The observed shifts in agricultural production do considerably raise the profitability of agricultural production and hence the incomes of smallholder farmers. The findings are not driven by changes in the labor or cost intensity of those crops, which supports the idea that the causal mechanism underlying the observed changes is indeed an insurance effect.
Energy-Saving Effects of Progressive Pricing and Free CFL Bulb Distribution Program: Evidence from Ethiopia
Authors: Iimi Atsushi , Elahi Raihan , Kitchlu Rahul , Costolanski Peter 
Published: December 2016

Abstract
In Africa, about 70 percent of the total population still lives without electricity. Significant resources are needed to meet the gap. Demand-side management is crucial to curb the increasing demand even in developing countries. A traditional approach is to raise prices, but promoting energy-efficient products such as compact fluorescent lamp (CFL) bulbs is also a win-win proposition. While end-users can reduce their spending, power utilities can avoid costly investments in new generation capacity. This paper estimates the effects of progressive pricing as well as CFL distribution program in Ethiopia. It is found that the increasing block tariff structure reduced the demand: the price elasticity is estimated at 0.29. This is particularly useful to influence large-volume users, who are presumably the rich. The CFL program is also found effective to contain the electricity demand. The estimated impact is about 45 kWh per customer. This is significant energy savings particularly for low-volume users.
Tip Fold-over in Cochlear Implantation: Case Series
Authors: Zuniga M. Geraldine , Rivas Alejandro , Hedley-Williams Andrea , Gifford Rene H. , Dwyer Robert , Dawant Benoit M. , Sunderhaus Linsey W. , Hovis Kristen L. , Wanna George B. , Noble Jack H. , Labadie Robert F. 
Published: December 2016

Objective:
To describe the incidence, clinical presentation, and performance of cochlear implant (CI) recipients with tip fold-over.

Study Design:
Retrospective case series.

Setting:
Tertiary referral center.

Patients:
CI recipients who underwent postoperative computed tomography (CT) scanning.

Intervention(s):
Tip fold-over was identified tomographically using previously validated software that identifies the electrode array. Electrophysiologic testing including spread of excitation or electric field imaging (EFI) was measured on those with fold-over.

Main Outcome Measure(s):
Location of the fold-over; audiological performance pre and postselective deactivation of fold-over electrodes.

Results:
Three hundred three ears of 235 CI recipients had postoperative CTs available for review. Six (1.98%) had tip fold-over with 5/6 right-sided ears. Tip fold-over occurred predominantly at 270 degrees and was associated with precurved electrodes (5/6). Patients did not report audiological complaints during initial activation. In one patient, the electrode array remained within the scala tympani with preserved residual hearing despite the fold-over. Spread of excitation supported tip fold-over, but the predictive value was not clear. EFI predicted location of the fold-over with clear predictive value in one patient. At an average follow-up of 11 months, three subjects underwent deactivation of the overlapping electrodes with two of them showing marked audiological improvement.

Conclusion:
In a large academic center with experienced surgeons, tip fold-over occurred at a rate of 1.98% but was not immediately identifiable clinically. CT imaging definitively showed tip fold-over. Deactivating involved electrodes may improve performance possibly avoiding revision surgery. EFI may be highly predictive of tip fold-over and can be run intraoperatively, potentially obviating the need for intraop fluoroscopy.
Stimulus visibility controls the balance between attention-induced changes in contrast appearance and decision bias
Authors: Itthipuripat Sirawaj , Chang Kai-Yu , Bong Ashley , Serences John T 
Published: December 2016

AbstractWhile attention is known to improve information processing, whether attention can alter visual appearance has been a cornerstone of debate for 100+ years. Although recent studies suggest that attention can alter appearance, it has been argued that the reported appearance changes reflect response bias. Here, we provide a resolution to this debate by showing that attention has different effects on appearance and response bias depending on stimulus visibility. In a contrast judgment task where the contrast of attended and unattended stimuli varied across a full range of contrast values, human participants exhibited a substantial amount of response bias to the attended stimulus, when stimuli were hard to see. However, when stimuli were easier to see, response bias decreased and attention primarily increased perceived contrast. These results help constrain philosophical arguments about the cognitive penetrability of perception and reconcile the long-standing debate about the attention effect on appearance and response bias.
Engineered Cpf1 Enzymes with Altered PAM Specificities
Authors: Gao Linyi , Cox David B.T. , Yan Winston X. , Manteiga John , Schneider Martin , Yamano Takashi , Nishimasu Hiroshi , Nureki Osamu , Zhang Feng 
Published: December 2016

SummaryThe RNA-guided endonuclease Cpf1 is a promising tool for genome editing in eukaryotic cells1-5. Compared to other genome editing platforms, Cpf1 offers distinct advantages, such as the ability to easily target multiple genes simultaneously3, as well as low rates of off-target activity4, 5. However, theAcidaminococcus sp. BV3L6Cpf1 (AsCpf1), which has been successfully harnessed for genome editing, can only robustly cleave target sites preceded by a TTTV protospacer adjacent motif (PAM), which may limit its practical utility. To address this limitation, we used a structure- guided saturation mutagenesis screen to increase the targeting range of Cpf1. We engineered two variants of AsCpf1 with the mutations S542R/K607R and S542R/K548V/N552R that can cleave target sites with TYCV/CCCC and TATV PAMs, respectively, with enhanced activitiesin vitroand in human cells. Genome-wide assessment of off-target activity indicated that these variants retain a high level of DNA targeting specificity, which can be further improved by introducing mutations in non-PAM-interacting domains. Together, these variants increase the targeting range of AsCpf1 to one cleavage site for every ~8.7 bp in non-repetitive regions of the human genome, providing a useful addition to the CRISPR/Cas genome engineering toolbox.
Responsible lobbying: an empirical study in the EU
Authors: Bauer Theresa 
Published: December 2016

Purpose
The purpose of this paper is to explore the awareness and practice responsible lobbying in the EU. Specifically, the purpose of this paper is to examine the extent to which responsible lobbying criteria are fulfilled and to investigate whether responsible lobbying yields concrete benefits in the political arena.

Design/methodology/approach
The study takes a quantitative approach combining descriptive and multivariate partial least squares (PLS) analysis based on data gained from an online survey among lobbyists in the EU. A new measurement instrument for responsible lobbying is used that grasps the multidimensional phenomenon with a formative-formative higher-order construct.

Findings
The study reveals that criteria of responsible lobbying are fulfilled to a large extent according to the lobbyists. The PLS analysis confirms the applicability of the multidimensional model of responsible lobbying, although there is only a weak link between Dimension (1), referring to the company’s stated corporate social responsibility (CSR) commitment and coherence with lobbying and the second-order construct responsible lobbying. Based on the information given by respondents, the analysis provides evidence for a positive impact of responsible lobbying on both lobbying success and corporate reputation, but also for the dependence of these two variables on additional factors.

Originality/value
Responsible lobbying as an aligned approach to CSR and lobbying is a long neglected research topic, which has been gaining interest recently. This study contributes to empirical knowledge on the awareness and practice of responsible lobbying in the EU by taking a quantitative approach based on a solid theoretical foundation.
Mind: the gap – to advance CSR research, think about stakeholder cognition
Authors: L. Barnett Michael 
Published: December 2016

PurposeThe purpose of this paper is to develop a better understanding of how, and how well, stakeholders make decisions about rewarding firms for acts of social responsibility and punish firms for their lack thereof.Design/methodology/approachThe author integrates factors at the individual, firm, and industry levels that cause variation in how stakeholders attend to corporate social (ir)responsibility.FindingsThe author explicates the multi-level cognitive process stakeholders undertake in attending to firm’s actions and identifies limits on their ability to fulfill their central role in conditioning firms to be more socially responsible.Research limitations/implicationsThe author outlines areas for future research that can fill gaps in the understanding of how stakeholders notice, make sense of, and respond to corporate social practices.Social implicationsThe author argues that, under many conditions, business case or self-regulatory solutions may be inadequate to increase corporate social responsibility (CSR), and instead, formal regulatory solutions may prove necessary.Originality/valueThis paper brings needed structure to the literature on CSR. By delving deeper into the minds of stakeholders and outlining a multi-level cognitive process, it enables scholars to better address the key managerial issue of when, not simply whether, it pays to be good.
Science and responsibility for the well-being of the global community
Authors: Forge John 
Published: December 2016

Purpose
The purpose of this paper is to address the topic of the social responsibility and the scientist from a philosophical perspective. This is a (relatively) neglected topic, as philosophers have tended to focus on moral responsibility. Nevertheless, it is important, and timely.

Design/methodology/approach
Analytical, based on the author’s previous work. This is not an empirical study.

Findings
That it is essential for scientists to adopt a global outlook with respect to their social responsibilities. This is in (stark) contrast to the conclusion that would be reached for moral responsibility.

Research limitations/implications
In addition to offering some concrete proposals (see below), a general approach to the question is offered that will be useful for further work.

Practical implications
Were the suggestions for socially responsible science put into practice, then this would entail a re-orientation of some parts of scientific research; for instance, a moratorium on weapons research.

Social implications
The long-run social implications of not re-orienting science, for instance not to focus even more effort on climate change, will be negative in the extreme.

Originality/value
The social responsibility of science has always been important, but it is even more important today. By focussing on global responsibility, this paper offers a new approach.
Consumer preferences for regional meat products
Authors: Paustian Margit , Reinecke Franziska-Elisabeth , Theuvsen Ludwig 
Published: December 2016

PurposeConsumers are increasingly interested in the origin of their food, especially in the case of meat products where food safety issues are relevant. The purpose of this paper is to empirically examine the trend of regional food consumption and the influencing factors for consumer preferences of regional meat products. For the first time cognitive, normative and affective attributes, as well as point of purchase and socio-demographic characteristics, were put together in a conceptual framework to investigate which factors are influencing consumer preferences for regional meat products.Design/methodology/approachA representative sample of German consumers was surveyed in 2014. After measuring the determinants of perceived quality of regional meat products, an attribute-level factor analysis were used to test inter-dependence between the variables. All five factors, accounting for 77 percent of the sample, were examined by a binary logistic regression model.FindingsLogit regression analysis found that three factors, including normative and affective attributes, significantly affect and influence consumer preferences for regional meat products, whereas cognitive attributes have no significant influence on consumer preferences.Originality/valueThe findings have interesting implications for retailers with respect to meat marketing activities, as well as for researchers with respect to further research on regional meat products. Though, it comes out that it is promising to concentrate on normative and affective attributes regarding product presentation and meat marketing of regional meat products.
Barriers and facilitators of HACCP adoption in the Armenian dairy industry
Authors: Galstyan Suren H. , Harutyunyan Tsovinar L. 
Published: December 2016

Purpose
The purpose of this paper is to report the results of a study that investigated the barriers and facilitators associated with the adoption of a hazard analysis critical control point based food safety management system (HACCP FSMS) in dairy processing companies of Armenia.

Design/methodology/approach
A cross-sectional qualitative research design was employed to examine managerial experience and perceptions of barriers and drivers to organizational adoption of HACCP FSMS procedures. The data were collected in 20 food processing facilities in the dairy industry through individual in-depth interviews with their representatives and in governmental and non-governmental organizations through focus group discussions with 23 policy makers and food safety consultants. Diffusion of innovations theory provided a framework for systematic exploration of the phenomenon under study.

Findings
Most frequently reported drivers of adoption included enhanced traceability, increased export opportunities, improved organizational image, and broader accountability. Major impeding factors, such as high investment costs, value incompatibility, excessive documentation, inadequate physical and technological infrastructures, and low observability led to less favorable attitudes toward the organizational change needed for HACCP FSMS adoption. The results indicate that larger organizations with well-developed infrastructures and skilled workforce have an advantage over smaller organizations in the process of adoption.

Originality/value
This study provides a comprehensive theory-based analysis of perceived determinants of organization-wide adoption of HACCP-based system in Armenia. The results of the study support and extend the findings of earlier research and provide new insights into HACCP FSMS adoption across different contexts.
Exploring the acceptability of amaranth-enriched bread to support household food security
Authors: de Beer Hanli , Mielmann Annchen , Coetzee Lizelle 
Published: December 2016

Purpose
The purpose of this paper is to explore the acceptability of an identified staple product enriched with amaranth grain, a traditionally used wild plant familiar to most of the population, after households’ food security status revealed that the majority of them were either at risk or food insecure.

Design/methodology/approach
A two-phase non-experimental, quantitative survey design with purposive sampling was used to explore the variety of foods consumed and the food security status of lower skilled (n=63) and higher skilled (n=81) income-earning households. During the second phase, recipe development and sensory acceptance of bread enriched with grain amaranth (n=91) were determined. Descriptive and inferential statistics were used to analyse the data.

Findings
Food insecurity was evident among the majority of the lower skilled income households while nearly one in four households in both groups were at risk to become insecure. Daily consumption of chicken and maize meal was evident in lower income households while the frequency in higher income households were significantly less. Bread was found to be the most consumed food product among all households (p=0.001; r=0.455). Supplementation of wheat flour with amaranth flour, a nutritious traditionally familiar wild plant, to support households’ food consumption was investigated. Results from sensory evaluation panels revealed that both bread samples with different percentage of amaranth flour (15 and 25 per cent) were acceptable.

Originality/value
The most important contribution of this study is the re-introduction and incorporation of a traditional food, amaranth, into a modern frequently consumed food to support households’ nutritional and monetary demands to ultimately contribute to general well-being and household food security.
How convenient!? Adolescents’ vistas on food competences in a convenience context
Authors: Wahlen Stefan , van der Horst Hilje , Pothoff Roosje 
Published: December 2016

Purpose
Adolescents are at a stage in their life course in which they increasingly become choosers, buyers and preparers of food. Hence, they develop and employ required competences. Current food-related competences of adolescents are shaped in an environment with an abundance of convenience foods. Simultaneously food education has been limited in many western countries. The purpose of this paper is to scrutinize how young practitioners engage with the notion of convenience in a context with a strong presence of convenience foods.

Design/methodology/approach
Empirical data for this paper have been collected in a Dutch high school context following a participatory approach in focus group discussions. Data have been gathered from different food-related exercises within a classroom context.

Findings
The findings indicate that adolescents’ food competences and meanings are heavily shaped by the abundant presence of convenience foods. Adolescents perceive a nuanced picture of a skilful consumer that incorporates convenience foods in ways that minimize time efforts, preserves some preparatory tasks for fun cooking and has knowledge about health effects of fatty and salty foods.

Originality/value
The investigation takes a novel look on convenience food consumption from a practice perspective scrutinizing competences through the lens of adolescent practitioners. The authors make a plea for tapping into the potential of research on children and adolescents as novice performers of practices to understand how practices are shaped and changed and how practices recruit new practitioners.