bluuebunny/crossref_metadata_2025_split huggingface dataset:
TGF-β requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy
Authors: Ábrigo Johanna , Campos Fabian , Simon Felipe , Riedel Claudia , Cabrera Daniel , Vilos Cristian , Cabello-Verrugio Claudio 
Published: November 2017

Abstract
The transforming growth factor type-beta (TGF-β) induces skeletal muscle atrophy characterised by a decrease in the fibre’s diameter and levels of myosin heavy chain (MHC), also as an increase of MuRF-1 expression. In addition, TGF-β induces muscle atrophy by a mechanism dependent on reactive oxygen species (ROS). TGF-β signals by activating both canonical Smad-dependent, and non-canonical signalling pathways such as ERK1/2, JNK1/2, and p38 MAPKs. However, the participation of canonical and non-canonical signalling pathways in the TGF-β atrophic effect on skeletal muscle is unknown. We evaluate the impact of Smad and MAPK signalling pathways on the TGF-β-induced atrophic effect in C2C12 myotubes. The results indicate that TGF-β activates Smad2/3, ERK1/2 and JNK1/2, but not p38 in myotubes. The pharmacological inhibition of Smad3, ERK1/2 and JNK1/2 activation completely abolished the atrophic effect of TGF-β. Finally, the inhibition of these canonical and non-canonical pathways did not decrease the ROS increment, while the inhibition of ROS production entirely abolished the phosphorylation of Smad3, ERK1/2 and JNK1/2. These results suggest that TGF-β requires Smad3, ERK1/2 and JNK1/2 activation to produce skeletal muscle atrophy. Moreover, the induction of ROS by TGF-β is an upstream event to canonical and non-canonical pathways.
Leisurely consumption, the legacy of European cafes
Authors: Cleave Paul 
Published: November 2017

AbstractEating out for many is regarded as a leisure activity, embracing the consumption of food, drink and place. In contrast to the ubiquitous and homogenous branded coffee shops and cafes found in most cities are examples from earlier eras, which offer consumers a degree of differentiation. They represent a culinary legacy and heritage by association with time and place. Cafes are utilised in the two case study examples, Deller’s Café, Exeter, United Kingdom, and Café Kranzler, Berlin, Germany, as social spaces, and in the context of tourism, attractions. The appeal of social spaces with an historical legacy is presented as the basis for further social research opportunities. These, it is proposed present a way of looking at the past to learn about the present.
On the generalized quotient integrals on homogeneous spaces
Authors: Derikvand Tajedin , Kamyabi-Gol Rajab Ali , Janfada Mohammad 
Published: November 2017

AbstractA generalization of the quotient integral formula is presented and some of its properties are investigated. Also the relations between two function spaces related to the special homogeneous spaces are derived by using the general quotient integral formula. Finally, our results are supported by some examples.
The Effect of Residents’ Attitude toward Tourism on their Pro-Tourism Behaviour: A Case Study of Hua-Hin Prachubkirikhan
Authors: Homsud Noppanon 
Published: November 2017

AbstractThis study focused on the impact of attitude toward tourism on pro-tourism behaviour. The social exchange theory and theory of reasoned action were used to support this model. This study constructed a model for testing the relationship among welcome tourists behaviour, perceived local economy, personal benefit, attitude toward tourism, and pro-tourism behaviour. Empirical testing was used for observing the effect of the model. The sample comprised 408 people from Hua-hin Prachubkirikhan, who were selected by convenience sampling. The research instrument was a questionnaire that was divided into the following 4 parts: general data, perceived tourism impact (welcome tourists behaviour, perceived local economy, and personal benefit), attitude toward tourism, and pro-tourism behaviour. Statistical analysis methods included frequency, percentage, mean, standard deviation, and structural equation modelling. All the hypotheses were supported, indicating a significant positive effect of attitude toward tourism on pro-tourism behavior.
Motion-Induced Blindness Using Increments and Decrements of Luminance
Authors: Stine Wm Wren , Levesque Patricia A. , Lusignan Megan E. , Kitt Andrew J. 
Published: November 2017

AbstractMotion-induced blindness describes the disappearance of stationary elements of a scene when other, perhaps non-overlapping, elements of the scene are in motion. We measured the effects of increment (200.0 cd/m2) and decrement targets (15.0 cd/m2) and masks presented on a grey background (108.0 cd/m2), tapping into putative ON- and OFF-channels, on the rate of target disappearance psychophysically. We presented two-frame motion, which has coherent motion energy, and dynamic Glass patterns and dynamic anti-Glass patterns, which do not have coherent motion energy. Using the method of constant stimuli, participants viewed stimuli of varying durations (3.1 s, 4.6 s, 7.0 s, 11 s, or 16 s) in a given trial and then indicated whether or not the targets vanished during that trial. Psychometric function midpoints were used to define absolute threshold mask duration for the disappearance of the target. 95% confidence intervals for threshold disappearance times were estimated using a bootstrap technique for each of the participants across two experiments. Decrement masks were more effective than increment masks with increment targets. Increment targets were easier to mask than decrement targets. Distinct mask pattern types had no effect, suggesting that perceived coherence contributes to the effectiveness of the mask. The ON/OFF dichotomy clearly carries its influence to the level of perceived motion coherence. Further, the asymmetry in the effects of increment and decrement masks on increment and decrement targets might lead one to speculate that they reflect the ‘importance’ of detecting decrements in the environment.
Science Integrated Learning Model to Enhance The Scientific Work Independence of Student Teacher in Indigenous Knowledge Transformation
Authors: Parmin P. , Sajidan S. , Ashadi A. , Sutikno S. , Fibriana F. 
Published: November 2017

<p>The scientific work independence is the core competency of student teacher of science. In this research, the effectiveness of the Science Integrated Learning Model (SIL) was measured in term of the scientific work independence of student teacher of science in changing the society’s original knowledge into scientific knowledge. The changing was measured through Ethnoscience learning. The experimental method was used with the control group and experimental group in three different universities. The result of the t-test shows a correlation coefficient significance value at 0.000 &lt; 0.05. Therefore, it concludes that there is not any difference between the experimental and control group. However, there is an effect of model application on the independence of the scientific work of student teacher of science. </p>
A Resource for the Allele-Specific Analysis of DNA Methylation at Multiple Genomically Imprinted Loci in Mice
Authors: Wasson Jadiel A , Birol Onur , Katz David J 
Published: November 2017

AbstractGenomically imprinted loci are expressed mono-allelically, dependent upon the parent of origin. Their regulation not only illuminates how chromatin regulates gene expression but also how chromatin can be reprogrammed every generation. Because of their distinct parent-of-origin regulation, analysis of imprinted loci can be difficult. Single nucleotide polymorphisms (SNPs) are required to accurately assess these elements allele specifically. However, publicly available SNP databases lack robust verification, making analysis of imprinting difficult. In addition, the allele-specific imprinting assays that have been developed employ different mouse strains, making it difficult to systemically analyze these loci. Here, we have generated a resource that will allow the allele-specific analysis of many significant imprinted loci in a single hybrid strain of Mus musculus. This resource includes verification of SNPs present within 10 of the most widely used imprinting control regions and allele-specific DNA methylation assays for each gene in a C57BL/6J and CAST/EiJ hybrid strain background.
Luxación de codo asociada a fractura de cóndilo externo y cabeza del radio. Presentación de un caso y revisión bibliográfica. [Elbow luxation associated with external condyle and radial head fracture. Case report and literature review].
Authors: Curbelo Nova Patricia Carolina , Casales Nicolás 
Published: November 2017

Presentamos el caso atípico de una luxación compleja de codo, en un adulto, asociada a fractura de cabeza de radio y cóndilo humeral externo. Se realizó reducción cerrada de la luxación y posterior tratamiento quirúrgico con reducción abierta y fijación interna de la fractura de cóndilo externo. Se obtuvo un codo estable que luego de la rehabilitación logró una buena movilidad y un rápido reintegro laboral. AbstractWe report the unusual case of a complex elbow dislocation in an adult associated with radial head and external humeral condyle fracture. Closed reduction of dislocation and subsequent surgical treatment were performed with open reduction and internal fixation of lateral condyle fracture. A stable elbow after rehabilitation was achieved showing a good range of motion and the patient returned to work rapidly.
Pain Relief After Operative Treatment of an Extremity Fracture
Authors: Helmerhorst Gijs T.T. , Zwiers Ruben , Ring David , Kloen Peter 
Published: November 2017

Background:
Opioid pain medication is frequently given to patients recovering from a surgical procedure for an extremity fracture in spite of evidence that acetaminophen may be adequate. The aim of this study was to determine whether prescription of step 1 pain medication (acetaminophen) is noninferior to step 2 pain medication (acetaminophen and tramadol) after operative treatment of an extremity fracture.

Methods:
Fifty-two patients with a single extremity fracture were randomized from July 2012 to March 2015 in this 2-week follow-up, noninferiority trial in a level-I trauma center in the Netherlands. Patients were randomly assigned to receive step 1 (acetaminophen) or step 2 (acetaminophen and tramadol) medication in standard doses on an as-needed basis on discharge. Intention-to-treat and per-protocol analyses were conducted. The primary outcome was self-reported satisfaction with pain relief measured on an 11-point ordinal scale. The hypothesis being tested was formulated before the collection of data. The mean differences between the groups were reported for intention-to-treat and per-protocol analyses.

Results:
A total of 52 patients, with equal baseline characteristics, were analyzed in this study; the step 1 group consisted of 27 subjects and the step 2 group consisted of 25 subjects. The mean satisfaction with pain management was 8.3 for step 1 and 8.5 for step 2 medications. This mean difference of 0.2 point (95% confidence interval [CI], −0.78 to 1.30 points) did not exceed the noninferiority margin of 2.0 points, indicating that step 1 was noninferior to step 2. A similar result was found in the per-protocol analysis (mean difference, 0.2 point [95% CI, −1.03 to 1.57 points]).

Conclusions:
This study offers evidence to suggest that prescription of acetaminophen is not inferior compared with acetaminophen and tramadol in patients who underwent operative treatment for an extremity fracture. Given that tramadol has more side effects and is potentially habit-forming, acetaminophen should be considered the mainstay for pain relief in patients recovering from extremity fracture surgical procedures.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Preferably Not My Surgery
Authors: Edgington Jonathan P. , Petravick Michael E. , Idowu Olumuyiwa A. , Lee Michael J. , Shi Lewis L. 
Published: November 2017

Background:
Concurrent and overlapping surgical procedures are a timely topic. The 2 largest publications on the topic were limited to a journalistic overview and a government committee report. Since then, a recent survey of paid individuals found that they disapprove of overlapping surgical procedures in many cases. Still, we are aware of no work that specifically polled patients and their family members about their beliefs on concurrent and overlapping surgical procedures. We hypothesized that patients and family members will be uncomfortable with 1 surgeon performing overlapping or concurrent surgical procedures.

Methods:
A survey about concurrent and overlapping surgical procedures was given to 200 patients and their family members at a single, urban academic medical center. Participants were asked to respond to questions about their knowledge of concurrent and overlapping surgical procedures, their comfort with different surgical scenarios, and their beliefs on possible reasons for such surgical scenarios. Individuals were approached about the survey until 200 patients and family members responded.

Results:
On average, respondents were neutral with surgical procedures involving overlap of 2 noncritical portions and were not comfortable with overlap involving a critical portion of 1 or both surgical procedures. They agreed that hospitals allow overlapping surgical procedures to increase revenue.

Conclusions:
Patients undergoing a surgical procedure at an academic medical center and their family members were neutral or uncomfortable with concurrent or overlapping surgical procedures, affirming the hypothesis. Knowing these preferences is relevant to surgeons’ practices and to informed consent discussions. It appears beneficial for surgeons to address the advantages and disadvantages of overlapping surgical procedures with their patients if applicable.
Analisis Keunggulan Kompetitif Ubikayu terhadap Jagung dan Kedelai di Kabupaten Lampung Tengah
Authors: Asnawi Robet - , Mejaya Made Jana 
Published: November 2017

Cassava is a major food crops which widely developed in Lampung province, it caused high adaptability, easily cultivated, smallest risk of failure, and high price. The study was objective to analyze competitive advantage of casava farming system compared to maize and soybean farming system. The activity were conducted at Central Lampung regency from April 2012 to February 2013. The primary data were obtained from respondents with sample of 90 farmers, using survey methods with structured interviews and questionnaires. Secondary data were obtained from the office of relevant agencies and BPS Lampung. Data analysis were financial analysis and competitive advantage analysis. The results showed that cassava farming more profitable than maize and soybean farming system income Rp.21.109.000/ha and R/C of 2,91 compared to corn farming income Rp.15.935.000 and R/C of 2,01 and soybean farming income Rp.5.187.800/ha and R/C of 1,48. Cassava farming system will be competitive compared corn and soybeans farming on the productivity levels at least 34.567 kg/ha and 20,788 kg/ha and cassava price at least IDR 654/kg and IDR 394/kg.
Kompatibilitas Sumber Inokulan Fungi Mikoriza Arbuskular pada Kedelai dengan Budidaya Jenuh Air
Authors: Muis Ridwan , Ghulamahdi Munif , Melati Maya , Purwono Purwono , Mansur Irdika 
Published: November 2017

The main problem encountered by soybean crop in acid sulfate tidal lands is less availability of P, because of its chemical bond with Fe. Heavy dose of fertilization often lead to high fertilizer residue, wich could be used for crops farming using AMF. Research was conducted to study the effect of soybean culturing technique and AMF inoculants source on growth of soybean. The treatments consisted two factors, arranged in a randomized block design with three replications. The first factor was four inoculants sources of AMF, namely AMF and without inoculation AMF, inoculants from rhizospheres of kudzu (Pueraria javanica), sorghum (Sorghum bicolor), corn (Zea mays) and soybean (Glycine max). The second factor was culturing tehnique, namely water saturated and dry soil culture. Soybeans were grown in pots containing 5 kg soil derived from tidal land, Simpang Village, District of Berbak, East Tanjung Jabung Regency, Jambi Province. Results showed that the interaction saturated soil culture with inoculants from corn’s rhizosphere had positive effect on the variability of N, P and K uptake, N and P content in the plant, relative efficiency of inoculants and relative efficiency of P uptake, stem diameter, biomass dry weight, the number of filled pods and seed dry weight of soybeans. Dry soil culture with inoculants of corn’s rhizosphere had greater root colonization, but overall for the growth and grain yield of soybean, saturated soil culture with inoculants from corn rhizosphere has better effect on other growth variables.
ON THE ISSUE OF THE PECULIARITIES OF SURGICAL TREATMENT OF VARIOUS HISTOLOGICAL VARIANTS OF AMELOBLASTOMA
Authors: Tsimbalist N. S. , Rybalskaya V. F. , Semkin V. A. , Nerobeev A. I. , Babichenko I. I. 
Published: November 2017

The typical treatment of ameloblastoma is by surgery. The result of the procedure nevertheless does not always lead to complete healing of the sickness but to a recurrence during the post-operative period. It has been reported by a number of authors that the recurrence of the condition is influenced by a number of factors such as the kind of surgical intervention, the histological variant of the ameloblastoma and the incomplete removal of the tumor. The purpose of this research is to study the incidence of recurrence of ameloblastoma after surgery, taking into consideration type of surgery and size of the tumor. A study of 76 cases of ameloblastoma with different histological structures was undertaken in the laboratory of pathological anatomy of Central Research Institute of Dental and Maxillofacial Surgery. Data such as the recurrence of the disease and tumors size was collected, registered and analysed. The size of the tumors was expressed in conventional units. The analysis showed that basal cell and plexiform variants of ameloblastoma are often relate to cases with aggressive clinical courses. The tendency to the recurrence of the disease was also observed in the follicular and acanthomatous variants. According to the results of this study, cases of peripheral variants of ameloblastoma have the best prognosis.
Characterization of sludge properties for sewage treatment in a practical-scale down-flow hanging sponge reactor: oxygen consumption and removal of organic matter, ammonium, and sulfur
Authors: Nomoto Naoki , Hatamoto Masashi , Ali Muntjeer , Jayaswal Komal , Iguchi Akinori , Okubo Tsutomu , Takahashi Masanobu , Kubota Kengo , Tagawa Tadashi , Uemura Shigeki , Yamaguchi Takashi , Harada Hideki 
Published: November 2017

Abstract
The characteristics of sludge retained in a down-flow hanging sponge reactor were investigated to provide a better understanding of the sewage treatment process in the reactor. The organic removal and sulfur oxidation conditions were found to differ between the first layer and the following three layers. It was found that 63% and 59% of the organic matter was removed in the first layer, even though the hydraulic retention time was only 0.2 h. It is thought that the organic removal resulted from aerobic and anaerobic biodegradation on the sponge medium. The sulfate concentration increased 1.5–1.9-fold in the first layer, with almost no subsequent change in the second to fourth layers. It was shown that oxidation of sulfide in the influent was completed in the first layer. The result of the oxygen uptake rate test with an ammonium nitrogen substrate suggested that the ammonium oxidation rate was affected by the condition of dissolved oxygen (DO) or oxidation–reduction potential (ORP).
Prediction of sludge bulking using the knowledge-leverage-based fuzzy neural network
Authors: Han Honggui , Liu Zheng , Ge Luming , Qiao Junfei 
Published: November 2017

Abstract
One of the most important steps and the main bottleneck of the activated sludge wastewater treatment process (WWTP) is the secondary clarification, where sludge bulking is still a widespread problem. In this paper, an intelligent method, based on a knowledge-leverage-based fuzzy neural network (KL-FNN), is developed to predict sludge bulking online. This proposed KL-FNN can make full use of the data and the existing knowledge from the operation of WWTP. Meanwhile, a transfer learning mechanism is applied to adjust the parameters of the proposed method to improve the predicting accuracy. Finally, this proposed method is applied to a real wastewater treatment plant for predicting the sludge bulking risk, and then for predicting the sludge bulking. The experimental results indicate that the proposed prediction method can be used as a tool to achieve better performance and adaptability than the existing methods in terms of predicting accuracy for sludge bulking.
Relationship between voice function and skeletal effects of rapid maxillary expansion
Authors: Bilgiç Fundagül , Damlar İbrahim , Sürmelioğlu Özgür , Sözer Özlem Akıncı , Tatlı Ufuk 
Published: November 2017

ABSTRACT

Objective:
To evaluate the effects of rapid maxillary expansion (RME) on the vocal quality, maxillary central incisors, midpalatal suture, and nasal cavity in patients with maxillary crossbite.

Materials and Methods:
Coronal CT scans of 30 subjects (14 boys, 16 girls; mean age, 12.01 ± 0.75) were taken before RME (T0), and at the end of the expansion phase (T1). Voice samples of all patients were recorded with a high-quality condenser microphone (RODE NT2-A) on a desktop computer at T0 and T1. Statistical analyses were performed using a paired-sample t-test. The degree of association between the changes in the voice parameters and nasal width was assessed with Pearson's correlation.

Results:
RME treatment produced a significant increase in the transverse dimensions of the midpalatal suture and nasal cavity between T0 and T1 (P &lt; .05). The maximum F0 and jitter (%) results were shown to decrease statistically significantly from T0 to T1 (P &lt; .001 and P = .042, respectively). Between T0 and T1, shimmer (%) and shimmer (dB) exhibited statistically significant increases (P = .037 and P = .019, respectively).

Conclusions:
After RME therapy, voice quality differences were found to be associated with increases in nasal width.