bluuebunny/crossref_metadata_2025_split huggingface dataset:
A clinical update on posttraumatic stress disorder in burn injury survivors
Authors: McLean Loyola , Chen Runsen , Kwiet Julia , Streimer Jeffrey , Vandervord John , Kornhaber Rachel 
Published: April 2017

Objectives: Burn injuries are complex traumatic events carrying high risks of acute physical and psychosocial morbidity. With greater survival, clinical and research attention has turned to psychosocial recovery outcomes and risk factors. It is timely to summarise current issues in posttraumatic disorders after burn injury for mental health and integrative care clinicians. Posttraumatic stress disorder (PTSD) is a common outcome of severe burn injury. There are difficulties in delivering current best practice treatments to many survivors especially those in rural and remote areas and those with comorbidities. Vicarious traumatization of clinicians, families and carers requires attention and internationally there are moves to psychosocial screening and outcome tracking. Conclusions: The role of the multidisciplinary treatment, integrated and trauma-informed care is essential. While level 1 evidence for PTSD treatments theoretically applies, adaptations that consider comorbidities and treatment contexts are often essential with further research required.
Cumulative Risk and Physiological Stress Responses in African American Adolescents
Authors: Kliewer Wendy , Robins Jo Lynne W. 
Published: April 2017

Objective: To investigate associations between components of cumulative risk (CR) and physiological stress responses in African American adolescents and evaluate emotion regulation as a mediator and sex as a moderator of these associations. Methods: Cortisol and salivary alpha amylase (sAA) were collected in adolescents ( N = 205; 55% female; 12.1 ± 1.6 years at baseline) as part of a longitudinal study of stress and adjustment in families. CR was assessed at baseline and emotion regulation was assessed at baseline and 2 years later at Wave 3 (W3) using caregiver and adolescent reports. Cortisol and sAA responses to the social competence interview were assessed at W3. Results: Repeated-measures analyses of variance predicting cortisol and controlling for time of day, adolescent age, medication usage, and pubertal status revealed significant interactions of time with both psychosocial and sociodemographic risk. In both analyses, youths with higher levels of risk showed a steeper decline in cortisol than youths with lower levels of risk. In parallel analyses predicting sAA, time interacted with psychosocial but not with sociodemographic risk. There were no interactions with sex in any of the analyses. Although CR was associated with changes in emotion regulation, there was no evidence that these changes accounted for the observed CR–stress response associations. Conclusions: These findings illustrate the potential importance of disentangling CR and suggest that additional work is needed to help explicate why and how CR is associated with specific physiological responses to stress.
A systematic review of transition studies of pulmonary arterial hypertension specific medications
Authors: Sofer Avraham , Ryan Michael J. , Tedford Ryan J. , Wirth Joel A. , Fares Wassim H. 
Published: April 2017

Pulmonary arterial hypertension (PAH) is a progressive potentially fatal disease. Multiple pharmacologic options are now available, which facilitated transitions between different therapeutic options, although the evidence for such transitions has not been well described. We sought to review the evidence supporting the safety and/or efficacy of transitioning between PAH‐specific medications. We performed a systematic review of all published studies in the Medline database between 1 January 2000 and 30 June 2016 reporting on any transition between the currently Food and Drug Administration (FDA)‐approved PAH‐specific medications. Studies reporting on three or more adult patients published in the English language reporting on transitions between FDA‐approved PAH medications were extracted and tabulated. Forty‐one studies met the selection criteria, nine of which included less than eight patients (and thus were reported separately in the supplement), for a total of 32 studies. Transitioning from parenteral epoprostenol to parenteral treprostinil appears to be safe and efficacious in patients who have less severe disease and more favorable hemodynamics. Transitioning from a prostacyclin analogue to an oral medication may be successful in patients who have favorable hemodynamics and stable disease. There is conflicting evidence supporting the transition from a parenteral to an inhaled prostacyclin analogue, even in patients who are on background oral therapy. Currently, the only evidence in support of transitioning between oral PDE5 inhibitors is from sildenafil to tadalafil. Patients on higher doses of sildenafil are more likely to fail. In patients with liver abnormalities due to bosentan or sitaxentan, the transition to ambrisentan appears to be safe and can result in clinical improvement. Studies regarding PAH medication transitions are limited. Patients who have less severe disease, better functional status, and are on lower medications doses may be more successful at transitioning.
Comparison of six methods to estimate adherence in an ART-naïve cohort in a resource-poor setting: which best predicts virological and resistance outcomes?
Authors: Orrell Catherine , Cohen Karen , Leisegang Rory , Bangsberg David R. , Wood Robin , Maartens Gary 
Published: April 2017

AbstractBackgroundIncomplete adherence to antiretroviral therapy (ART) results in virologic failure and resistance. It remains unclear which adherence measure best predicts these outcomes. We compared six patient-reported and objective adherence measures in one ART-naïve cohort in South Africa.MethodsWe recruited 230 participants from a community ART clinic and prospectively collected demographic data, CD4 count and HIV-RNA at weeks 0, 16 and 48. We quantified adherence using 3-day self-report (SR), clinic-based pill count (CPC), average adherence by pharmacy refill (PR-average), calculation of medication-free days (PR-gaps), efavirenz therapeutic drug monitoring (TDM) and an electronic adherence monitoring device (EAMD). Associations between adherence measures and virologic and genotypic outcomes were modelled using logistic regression, with the area under the curve (AUC) from the receiver operator characteristic (ROC) analyses derived to assess performance of adherence measures in predicting outcomes.ResultsAt week 48 median (IQR) adherence was: SR 100% (100–100), CPC 100% (95–107), PR-average 103% (95–105), PR-gaps 100% (95–100) and EAMD 86% (59–94), and efavirenz concentrations were therapeutic (>1 mg/L) in 92%. EAMD, PR-average, PR-gaps and CPC best predicted virological outcome at week 48 with AUC ROC of 0.73 (95% CI 0.61–0.83), 0.73 (95% CI 0.61–0.85), 0.72 (95% CI 0.59–0.84) and 0.64 (95% CI 0.52–0.76) respectively. EAMD, PR-gaps and PR-average were highly predictive of detection of resistance mutations at week 48, with AUC ROC of 0.92 (95% CI 0.87–0.97), 0.86 (0.67–1.0) and 0.83 (95% CI 0.65–1.0) respectively. SR and TDM were poorly predictive of outcomes at week 48.ConclusionEAMD and both PR measures predicted resistance and virological failure similarly. Pharmacy refill data is a pragmatic adherence measure in resource-limited settings where electronic monitoring is unavailable.Trial registrationThe trial was retrospectively registered in the Pan African Clinical Trials Registry, number PACTR201311000641402, on the 13 Sep 2013 (www.pactr.org). The first participant was enrolled on the 12th July 2012. The last patient last visit (week 48) was 15 April 2014
Efficacy and safety of setipiprant in seasonal allergic rhinitis: results from Phase 2 and Phase 3 randomized, double-blind, placebo- and active-referenced studies
Authors: Ratner Paul , Andrews Charles P. , Hampel Frank C. , Martin Bruce , Mohar Dale E. , Bourrelly Denis , Danaietash Parisa , Mangialaio Sara , Dingemanse Jasper , Hmissi Abdel , van Bavel Jay 
Published: April 2017

AbstractBackgroundAntagonism of chemoattractant receptor-homologous molecule on T-helper type-2 cells (CRTH2), a G-protein coupled receptor for prostaglandin D2, could be beneficial for treating allergic disorders. We present findings on the efficacy and safety/tolerability of a CRTH2 antagonist (setipiprant) in participants with seasonal allergic rhinitis (AR) in a real-life setting over 2 weeks.MethodsA Phase 2 trial and a Phase 3 trial were conducted at seven centers in Texas, USA during the Mountain Cedar pollen season. Both were prospective, randomized, double-blind, placebo- and active-referenced (cetirizine) studies. The Phase 2 trial assessed setipiprant 100–1000 mg b.i.d. and 1000 mg o.d. versus placebo in adult and elderly participants. The Phase 3 trial assessed setipiprant 1000 mg b.i.d. in adolescent, adult, and elderly participants. Efficacy was assessed using daytime nasal symptom scores (DNSS), night-time nasal symptom scores (NNSS) and daytime eye symptom scores (DESS).Results579 participants were randomized in the Phase 2 trial (mean age 41.6–43.4 years); 630 were randomized in the Phase 3 trial (mean age 37.5–40.7 years). A statistically significant, dose-related improvement in mean change from baseline DNSS was observed over 2 weeks with setipiprant 1000 mg b.i.d. versus placebo in the Phase 2 trial (−0.15 [95% CI −0.29, −0.01]; p = 0.030). Setipiprant 1000 mg b.i.d. had no significant effect on this endpoint in the Phase 3 trial (−0.02 [95% CI −0.12, 0.07]; p = 0.652). Total and individual NNSS and DESS symptom scores were significantly improved with setipiprant 1000 mg b.i.d. versus placebo in the Phase 2 but not the Phase 3 trial. Setipiprant showed a favorable safety/tolerability profile.ConclusionsThe Phase 2 trial was the first large clinical study to assess a CRTH2 antagonist in seasonal AR in a real-life setting. Setipiprant dose-related efficacy in the Phase 2 trial was not confirmed during Phase 3. Setipiprant was well tolerated in both studies.Trial registrationNCT01241214 and NCT01484119
The first Canadian experience with the Afirma® gene expression classifier test
Authors: Kay-Rivest Emily , Tibbo Jamie , Bouhabel Sarah , Tamilia Michael , Leboeuf Rebecca , Forest Veronique-Isabelle , Hier Michael P. , Savoury Loren , Payne Richard J. 
Published: April 2017

Background Thyroid nodules are common and often benign, although prove to be malignant upon surgical pathology in 5–15% of cases. When assessed with ultrasound-guided fine-needle aspiration (USFNA), 15–30% of the nodules yield an indeterminate result. The Afirma® gene expression classifier (AGEC) was developed to improve management of indeterminate thyroid nodules (ITNs) by classifying them as “benign” or “suspicious.” Objectives were (1) to assess the performance of the AGEC in two Canadian academic medical centres (2), to search for inter-institutional variation and (3) to compare AGEC performance in Canadian versus American institutions. Methods We undertook a retrospective cohort study of patients with indeterminate cytopathology (Bethesda Class III or IV) as per USFNA who underwent AGEC testing. We reviewed patient demographics, cytopathological results, AGEC data and, if the patient underwent surgery, results from their final pathology. Results In total, we included 172 patients with Bethesda Class III or IV thyroid nodules underwent AGEC testing, 109 in Montreal, Quebec and 63 in St. John's, Newfoundland, in this study. Among the nodules sent for testing, 55% (60/109) in Montreal and 46% (29/63) in St. John's returned as “benign.” None of these patients underwent surgery. On the other hand, 45% (49/109) nodules in Montreal and 54% (34/63) in St. John's were found to be “suspicious,” for a total of 83 specimens. Seventy seven of these patients underwent surgery. Both in Montreal and St. John's, the final pathology yielded malignant thyroid disease in approximately 50% of the specimens categorized as “suspicious.” Since 2013, no patient diagnosed with a benign nodule as per AGEC testing was found to harbor a malignant thyroid nodule on follow-up. Conclusions Molecular analysis is increasingly used in the management of indeterminate thyroid nodules. This study highlights the experience of two Canadian centres with AGEC testing. We found inter-institutional variability in the rate of nodules returning as “benign,” however we found similar rates of confirmed malignancy in nodules returning as “suspicious.” According the literature, results for AGEC testing in two Canadian institutions align with results reported in American centres.
Emerging roles of MICAL family proteins – from actin oxidation to membrane trafficking during cytokinesis
Authors: Frémont Stéphane , Romet-Lemonne Guillaume , Houdusse Anne , Echard Arnaud 
Published: April 2017

ABSTRACT
Cytokinetic abscission is the terminal step of cell division, leading to the physical separation of the two daughter cells. The exact mechanism mediating the final scission of the intercellular bridge connecting the dividing cells is not fully understood, but requires the local constriction of endosomal sorting complex required for transport (ESCRT)-III-dependent helices, as well as remodelling of lipids and the cytoskeleton at the site of abscission. In particular, microtubules and actin filaments must be locally disassembled for successful abscission. However, the mechanism that actively removes actin during abscission is poorly understood. In this Commentary, we will focus on the latest findings regarding the emerging role of the MICAL family of oxidoreductases in F-actin disassembly and describe how Rab GTPases regulate their enzymatic activity. We will also discuss the recently reported role of MICAL1 in controlling F-actin clearance in the ESCRT-III-mediated step of cytokinetic abscission. In addition, we will highlight how two other members of the MICAL family (MICAL3 and MICAL-L1) contribute to cytokinesis by regulating membrane trafficking. Taken together, these findings establish the MICAL family as a key regulator of actin cytoskeleton dynamics and membrane trafficking during cell division.
Restoration of Color Caused by Redox Reactions of Copper(I) Complexes Bearing 2,2′-Bipyridine and (R)-(+)-2,2′-Bis(di-p-tolylphosphino)-1,1′-binaphthyl Ligands
Authors: Nishikawa Michihiro , Tsuji Masakata , Ohishi Tomoyuki , Tsubomura Taro 
Published: April 2017

Abstract
Copper(I) complexes bearing (R)-(+)-2,2′-bis(di-p-tolylphosphino)-1,1′-binaphthyl and 2,2′-bipyridine derivative ligands were newly synthesized and characterized. Despite many known copper(I) complexes bearing diimine and diphosphine ligands, which are well-investigated for their photofuntions, exhibit irreversible oxidation, the present complex shows clear spectral changes on oxidation and reduction reactions.
AR2, a novel automatic muscle artifact reduction software method for ictal EEG interpretation: Validation and comparison of performance with commercially available software
Authors: Weiss Shennan Aibel , Asadi-Pooya Ali A , Vangala Sitaram , Moy Stephanie , Wyeth Dale H , Orosz Iren , Gibbs Michael , Schrader Lara , Lerner Jason , Cheng Christopher K , Chang Edward , Rajaraman Rajsekar , Keselman Inna , Churchman Perdro , Bower-Baca Christine , Numis Adam L , Ho Michael G , Rao Lekha , Bhat Annapoorna , Suski Joanna , Asadollahi Marjan , Ambrose Timothy , Fernandez Andres , Nei Maromi , Skidmore Christopher , Mintzer Scott , Eliashiv Dawn S , Mathern Gary W , Nuwer Marc R , Sperling Michael , Engel Jr Jerome , Stern John M 
Published: April 2017

Objective: To develop a novel software method (AR2) for reducing muscle contamination of ictal scalp electroencephalogram (EEG), and validate this method on the basis of its performance in comparison to a commercially available software method (AR1) to accurately depict seizure-onset location. Methods: A blinded investigation used 23 EEG recordings of seizures from 8 patients. Each recording was uninterpretable with digital filtering because of muscle artifact and processed using AR1 and AR2 and reviewed by 26 EEG specialists. EEG readers assessed seizure-onset time, lateralization, and region, and specified confidence for each determination. The two methods were validated on the basis of the number of readers able to render assignments, confidence, the intra-class correlation (ICC), and agreement with other clinical findings. Results: Among the 23 seizures, two-thirds of the readers were able to delineate seizure-onset time in 10 of 23 using AR1, and 15 of 23 using AR2 (p<0.01). Fewer readers could lateralize seizure-onset (p<0.05). The confidence measures of the assignments were low (probable-unlikely), but increased using AR2 (p<0.05). The ICC for identifying the time of seizure-onset was 0.15 (95% confidence interval (CI), 0.11-0.18) using AR1 and 0.26 (95% CI 0.21-0.30) using AR2. The EEG interpretations were often consistent with behavioral, neurophysiological, and neuro-radiological findings, with left sided assignments correct in 95.9% (CI 85.7-98.9%, n=4) of cases using AR2, and 91.9% (77.0-97.5%) (n=4) of cases using AR1. Conclusions: EEG artifact reduction methods for localizing seizure-onset does not result in high rates of interpretability, reader confidence, and inter-reader agreement. However, the assignments by groups of readers are often congruent with other clinical data. Utilization of the AR2 software method may improve the validity of ictal EEG artifact reduction.
On Integral Policies in Deterministic and Stochastic Distribution Systems
Authors: Bo Yang , Dawande Milind , Janakiraman Ganesh , McCormick S. Thomas 
Published: April 2017

The “integrality” question for dynamic optimization models of inventory control asks if there exists an integral optimal policy, given integral initial inventory levels, capacities, and demand realizations. One practical implication of this question lies in whether or not full-truckload (FTL) shipping is optimal if customer demand is in integral number of truckloads. In this paper, we investigate the integrality question in single-product, multiechelon distribution systems and show that integrality holds under deterministic demand but fails to hold under stochastic demand. In distribution systems with stochastic demand, less-than-truckload (LTL) shipping can be significantly cheaper than the cost of the optimal FTL shipping policy, even in the presence of economies of scale. For instance, this occurs in settings where shipping costs are expected to increase in the future and/or inventories are more expensive to hold upstream than downstream. In such situations, our results highlight the importance of strategically positioning inventory: LTL shipments can offer a more balanced allocation of inventory across the distribution network, leading to benefits that can exceed the savings from FTL shipments due to economies of scale. However, when the cost parameters are fairly constant across time and inventory holding costs are not significantly higher upstream than downstream, then the difference between the costs of optimal FTL and optimal LTL shipping is provably marginal. The online appendix is available at https://doi.org/10.1287/opre.2016.1586 .
When She Brings Home the Job Status: Wives’ Job Status, Status Leakage, and Marital Instability
Authors: Byrne Alyson , Barling Julian 
Published: April 2017

Women are increasingly represented in high status organizational positions. While the advancement of women into high status roles offers them many organizational benefits, the spillover and crossover effects of these high status positions on their marital relationships remain under explored. In this study, we focus on potential costs to the marital relationship when women in high status positions hold higher job status roles than their husbands. First, we examine the spillover effects of wives’ job status relative to their husbands’ on marital instability. We suggest that this relationship is indirect and mediated by negative thoughts and feelings toward their partners’ lower job status (which we refer to as “wives’ status leakage”) and decreased relationship satisfaction. Second, we investigate plausible crossover effects on husbands’ marital instability when wives have higher job status and suggest that husbands’ spousal support can moderate the indirect relationship between wives’ job status and wives’ marital instability. We explored these questions on 209 women in positions of high job status, a sample of 53 matched husband–wife dyads, and 92 of the wives who also completed questionnaires three years later. Full cross-sectional and longitudinal support emerged for the indirect spillover effects of wives’ job status on marital instability of wives, and direct crossover effects on husbands’ marital instability. In addition, the indirect relationship between wives’ job status on marital instability of wives was moderated by instrumental support. Theoretical contributions, practical implications, and future research suggestions are discussed. The online appendix is available at https://doi.org/10.1287/orsc.2017.1120 .
Implementation of Medicaid Managed Long-Term Services and Supports for Adults With Intellectual and/or Developmental Disabilities in Kansas
Authors: Williamson Heather J. , Perkins Elizabeth A. , Levin Bruce L. , Baldwin Julie A. , Lulinski Amie , Armstrong Mary I. , Massey Oliver T. 
Published: April 2017

Abstract
Many adults with intellectual and/or developmental disabilities (IDD) can access health and long-term services and supports (LTSS) through Medicaid. States are reforming their Medicaid LTSS programs from a fee-for-service model to a Medicaid managed LTSS (MLTSS) approach, anticipating improved quality of care and reduced costs, although there is limited evidence of MLTSS effectiveness. This study's objective was to contribute to the growing MLTSS research literature by describing MLTSS implementation in Kansas for adults with IDD. Thirty-one stakeholders completed in-depth semi-structured interviews, representing state or regional groups, service coordination providers, and family caregivers. Findings identify key aspects of the Centers for Medicare and Medicaid Services' new MLTSS regulations in the design and implementation of MLTSS programs.
CONCEPÇÕES DE PROFESSORAS DE EDUCAÇÃO INFANTIL SOBRE AS PRÁTICAS DOCENTES PARA A PRIMEIRA INFÂNCIA
Authors: Voltarelli Monique Aparecida , Monteiro Maria Iolanda 
Published: April 2017

Este artigo apresenta uma parte dos resultados obtidos pelo trabalho de mestrado que buscou compreender como se configuravam as práticas docentes de professoras iniciantes para atuar na primeira infância. Para desenvolver este estudo, realizaram-se observações de campo, registros em diário, análise documental e entrevista semiestruturada. Optou-se pela pesquisa de natureza qualitativa, que foi realizada em três Centros Municipais de Educação Infantil de uma Rede Municipal de ensino do interior de São Paulo, envolvendo três professoras iniciantes que trabalhavam com crianças de zero a três anos. O trabalho aponta para a necessidade de reflexão docente e discute sobre as concepções das professoras como determinantes na elaboração da ação pedagógica com as crianças. Apresenta a sociologia da infância como possibilidade de mudanças para atuar na primeira infância a partir da quebra de paradigmas sobre as crianças e a infância na sociedade.