bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological features and prognosis of omental gastrointestinal stromal tumor: evaluation of a pooled case series
Authors: Feng Fan , Tian Yangzi , Liu Zhen , Liu Shushang , Xu Guanghui , Guo Man , Lian Xiao , Fan Daiming , Zhang Hongwei 
Published: July 2016

AbstractClinicopathological features and prognosis of omental GISTs are limited due to the extremely rare incidence. Therefore, the aim of the present study was to investigate the clinicopathological features and prognosis of omental GISTs. Omental GISTs cases were obtained from our center and from case reports and clinical studies extracted from MEDLINE. Clinicopathological features and survivals were analyzed. A total of 99 cases of omental GISTs were enrolled in the present study. Omental GISTs occurred predominantly in greater omentum (78/99, 78.8%). The majority of tumors exceeded 10 cm in diameter (67/98, 68.3%) and were high risk (88/96, 91.7%). Histological type was correlated with tumor location and mutational status. The five year DFS and DSS was 86.3% and 80.6%, respectively. Mitotic index was risk factor for prognosis of omental GISTs. Prognosis of omental GISTs was worse than that of gastric GISTs by Kaplan-Meier analysis. However, multivariate analysis showed that the prognosis was comparable between the two groups. The majority of omental GISTs were large and high risk. Mitotic index was risk factor for prognosis of omental GISTs. The prognosis was comparable between omental and gastric GISTs.
Dynamical manipulation of electromagnetic polarization using anisotropic meta-mirror
Authors: Cui Jianhua , Huang Cheng , Pan Wenbo , Pu Mingbo , Guo Yinghui , Luo Xiangang 
Published: July 2016

AbstractPolarization control of electromagnetic wave is very important in many fields. Here, we propose an active meta-mirror to dynamically manipulate electromagnetic polarization state at a broad band. This meta-mirror is composed of a double-layered metallic pattern backed by a metallic flat plate and the active elements of PIN diodes are integrated into the meta-atom to control the reflection phase difference between two orthogonal polarization modes. Through switching the operating state of the PIN diodes, the meta-mirror is expected to achieve three polarization states which are left-handed, right-handed circular polarizations and linear polarization, respectively. We fabricated this active meta-mirror and validated its polarization conversion performance by measurement. The linearly polarized incident wave can be dynamically converted to right-handed or left-handed circular polarization in the frequency range between 3.4 and 8.8 GHz with the average loss of 1 dB. Furthermore, it also can keep its initial linear polarization state.
Noninvasive low-frequency electromagnetic stimulation of the left stellate ganglion reduces myocardial infarction-induced ventricular arrhythmia
Authors: Wang Songyun , Zhou Xiaoya , Huang Bing , Wang Zhuo , Zhou Liping , Wang Menglong , Yu Lilei , Jiang Hong 
Published: July 2016

AbstractNoninvasive magnetic stimulation has been widely used in autonomic disorders in the past few decades, but few studies has been done in cardiac diseases. Recently, studies showed that low-frequency electromagnetic field (LF-EMF) might suppress atrial fibrillation by mediating the cardiac autonomic nervous system. In the present study, the effect of LF-EMF stimulation of left stellate ganglion (LSG) on LSG neural activity and ventricular arrhythmia has been studied in an acute myocardium infarction canine model. It is shown that LF-EMF stimulation leads to a reduction both in the neural activity of LSG and in the incidence of ventricular arrhythmia. The obtained results suggested that inhibition of the LSG neural activity might be the causal of the reduction of ventricular arrhythmia since previous studies have shown that LSG hyperactivity may facilitate the incidence of ventricular arrhythmia. LF-EMF stimulation might be a novel noninvasive substitute for the existing implant device-based electrical stimulation or sympathectomy in the treatment of cardiac disorders.
Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson’s disease patients
Authors: Saito Yoshiro , Akazawa-Ogawa Yoko , Matsumura Akihiro , Saigoh Kazumasa , Itoh Sayoko , Sutou Kenta , Kobayashi Mayuka , Mita Yuichiro , Shichiri Mototada , Hisahara Shin , Hara Yasuo , Fujimura Harutoshi , Takamatsu Hiroyuki , Hagihara Yoshihisa , Yoshida Yasukazu , Hamakubo Takao , Kusunoki Susumu , Shimohama Shun , Noguchi Noriko 
Published: July 2016

AbstractParkinson’s disease (PD) is a progressive, age-related, neurodegenerative disorder and oxidative stress is an important mediator in its pathogenesis. DJ-1, the product of the causative gene of a familial form of PD, plays a significant role in anti-oxidative defence to protect cells from oxidative stress. DJ-1 undergoes preferential oxidation at the cysteine residue at position 106 (Cys-106) under oxidative stress. Here, using specific antibodies against Cys-106-oxidized DJ-1 (oxDJ-1), it was found that the levels of oxDJ-1 in the erythrocytes of unmedicated PD patients (n = 88) were higher than in those of medicated PD patients (n = 62) and healthy control subjects (n = 33). Elevated oxDJ-1 levels were also observed in a non-human primate PD model. Biochemical analysis of oxDJ-1 in erythrocyte lysates showed that oxDJ-1 formed dimer and polymer forms and that the latter interacts with 20S proteasome. These results clearly indicate a biochemical alteration in the blood of PD patients, which could be utilized as an early diagnosis marker for PD.
Techno‐economical lifetime assessment of power transformers rated over 50 MVA using artificial intelligence models
Authors: Zeinoddini‐Meymand Hamed , Vahidi Behrooz 
Published: July 2016

Power transformers are some of the most valuable and critical elements of power systems. Therefore, accurate and detailed assessment of technical and economical (techno‐economical) condition of the transformers is absolutely important to ensure its reliable operation. In this study, in order to assess the overall condition of the power transformers, an overall condition index (OI) obtained from technical lifetime index (TI) and economical lifetime index (EI) will be defined. The OI index, which provides a practical tool to assess the overall condition of the asset, combines the results of operating observations, field inspections, site and laboratory testing, and analysis of investment and operating and maintenance costs into an overall index. An adaptive neuro‐fuzzy inference system model is used to assess the TI, and a fuzzy logic model is used for EI evaluation. Large power transformers rated over 50 MVA, which are more critical and important in the network, are investigated. The models are developed using 170 experimental field datasets of transformer oil characteristics and dissolved gas analysis, and economical data such as operating and maintenance costs. The results prove that the models can be used to effectively assess the techno‐economical lifetime of power transformers.
Neoclassical tearing mode seeding by coupling with infernal modes in low-shear tokamaks
Authors: Kleiner A. , Graves J.P. , Brunetti D. , Cooper W.A. , Halpern F.D. , Luciani J.-F. , Lütjens H. 
Published: July 2016

Abstract
A numerical and an analytical study of the triggering of resistive MHD modes in tokamak plasmas with low magnetic shear core is presented. Flat q profiles give rise to fast growing pressure driven MHD modes, such as infernal modes. It has been shown that infernal modes drive fast growing islands on neighbouring rational surfaces. Numerical simulations of such instabilities in a MAST-like configuration are performed with the initial value stability code XTOR-2F in the resistive frame. The evolution of magnetic islands are computed from XTOR-2F simulations and an analytical model is developed based on Rutherford’s theory in combination with a model of resistive infernal modes. The parameter

Δ

′

is extended from the linear phase to the non-linear phase. Additionally, the destabilising contribution due to a helically perturbed bootstrap current is considered. Comparing the numerical XTOR-2F simulations to the model, we find that coupling has a strong destabilising effect on (neoclassical) tearing modes and is able to seed 2/1 magnetic islands in situations when the standard NTM theory predicts stability.
A tutorial on how (not) to over-interpret STRUCTURE/ADMIXTURE bar plots
Authors: Lawson Daniel J , van Dorp Lucy , Falush Daniel 
Published: July 2016

AbstractGenetic clustering algorithms, implemented in popular programs such as STRUCTURE and ADMIXTURE, have been used extensively in the characterisation of individuals and populations based on genetic data. A successful example is the reconstruction of the genetic history of African Americans who are a product of recent admixture between highly differentiated populations. Histories can also be reconstructed using the same procedure for groups which do not have admixture in their recent history, where recent genetic drift is strong or that deviate in other ways from the underlying inference model. Unfortunately, such histories can be misleading. We have implemented an approach (badMIXTURE, available at github.com/danjlawson/badMIXTURE) to assess the goodness of fit of the model using the ancestry “palettes” estimated by CHROMOPAINTER and apply it to both simulated data and real case studies. Combining these complementary analyses with additional methods that are designed to test specific hypotheses allows a richer and more robust analysis of recent demographic history based on genetic data.
A Dynamic Mode of Mitotic Bookmarking by Transcription Factors
Authors: Teves Sheila S. , An Luye , Hansen Anders S. , Xie Liangqi , Darzacq Xavier , Tjian Robert 
Published: July 2016

SummaryDuring mitosis, transcription is shut off, chromatin condenses, and most transcription factors (TFs) are reported to be excluded from chromosomes. How do daughter cells re-establish the original transcription program? Recent discoveries that a select set of TFs remain bound on mitotic chromosomes suggest a potential mechanism for maintaining transcriptional programs through the cell cycle termed mitotic bookmarking. Here we report instead that many TFs remain associated with chromosomes, and that the exclusion previously described is largely a fixation artifact. In particular, most TFs we tested are significantly enriched on mitotic chromosomes. Studies with Sox2 reveal that this mitotic interaction is more dynamic than in interphase and requires both DNA binding and nuclear import. Furthermore, this dynamic mode results from lack of transcriptional activation rather than decreased accessibility of underlying DNA sequences in mitosis. The nature of the cross-linking artifact prompts careful re-examination of the role of TFs in mitotic bookmarking.HighlightsMany transcription factors bind to mitotic chromosomesSox2 mitotic interaction is dynamic and requires DNA binding and nuclear importDNA remains highly accessible in mitotic chromosomesFormaldehyde-based cross-linking leads to mis-localization of TFs
Toxoplasma gondiiestablishes an extensive filamentous network consisting of stable F-actin during replication
Authors: Periz Javier , Whitelaw Jamie , Harding Clare , Lemgruber Leandro , Gras Simon , Reimer Madita , Insall Robert , Meissner Markus 
Published: July 2016

AbstractApicomplexan actin is well conserved and clearly important during the parasite's life cycle. Several studies assert that its polymerization kinetics are unusual, permitting only short, unstable F-actin filaments. However, it has not been possible to study actinin vivo, so its physiological role has remained obscure. This has led to functional models which are mutually conflicting, incompatible with actin behavior from other eukaryotes, and cannot explain actin's importance during basic processes such as parasite replication and egress. Here we use a chromobody that specifically binds F-actin to demonstrate thatToxoplasmaforms stable actin filamentsin vivo. F-actin is not only important for parasite replication, but also forms an extensive network that connects individuals both within and between parasitophorous vacuoles, and allows vesicles to be exchanged between parasites within a vacuole. During host cell egress, prior to motility, this network collapses in a calcium-dependent manner. This study demonstrates unexpected roles ofToxoplasmaactin during the asexual life cycle, and proves that formation of F-actin depends on a critical concentration of G-actin, implying a polymerization mechanism similar to mammalian actin.One Sentence SummaryToxoplasmaestablishes a stable F-actin network that is essential for replication and material transport between individual parasites.
Developing dynamic capabilities for learning and internationalization
Authors: Tallott Margaret , Hilliard Rachel 
Published: July 2016

Purpose– The purpose of this paper is to examine the development process of dynamic capabilities.Design/methodology/approach– The paper adopts a qualitative, longitudinal participant-observation research design. A single case study firm was observed over a ten-year period of active researcher engagement allowing for the collection of rich data on the development and deployment of dynamic capabilities as they evolved.Findings– Dynamic capabilities can be identified as sensing, seizing and transforming. They are capable of intentional development by managers through strategic decision making and deliberative learning, within a path-dependent evolution.Research limitations/implications– A longitudinal single case study allowed for a close look at the development of dynamic capabilities, exploring the context and conditions that facilitated change and tracing the evolution of the organization’s processes. However, this study remains subject to the limits of a single case approach. Future cross-sectional research would be able to test the conceptual model and allow for generalization of the findings to other populations of firms.Practical implications– The dynamic capability concept has been criticized for being of little practical use to managers. This research shows the process of intentional dynamic capability development, offering insights to practicing managers.Originality/value– This research adds to the relatively scant base of empirical work on dynamic capabilities and offers a conceptual model of dynamic capability development. The paper contributes to the neglected area of dynamic capabilities in SME’s, showing that the dynamic capability concept is relevant to this sector. The paper provides insight for practitioners by showing that intentional dynamic capability development is achievable.
Achieving a firm’s competitive advantage through dynamic capability
Authors: Lin Chinho , Tsai Hua-Ling 
Published: July 2016

Purpose
– The purpose of this paper is to propose a quantitative model to help managers diagnose what dynamic capabilities a firm needs to address the demands of a rapidly changing environment.

Design/methodology/approach
– A two-firm model based on the VRIO framework is built using quantitative techniques to assist top management in formulating and implementing strategies regarding when and how to develop a firm’s dynamic capabilities for achieving a competitive advantage. This model is developed by considering both internal and external competences, with the former measured by the features of the organizational capabilities of the focal firm and latter evaluated by comparing the relative utilities of the dynamic capabilities of the two competing firms.

Findings
– Three resource allocation strategies are introduced to guide a firm to leverage dynamic capability that generates strong organizational performance. The first two strategies are, respectively, synergy oriented, focussing on acquiring various knowledge or experiences of a capability, and uniqueness oriented, emphasizing the depth of knowledge and technology of the capabilities. The third one is a hybrid of the first two strategies.

Originality/value
– The proposed model is useful to help top management determine how and when to renew, bundle, and leverage resources and capabilities in a dynamic environment. It enables decision makers to detect changes in the competitive environment and take corrective action in a timely and appropriate manner.
Establishing a parsimonious model through comparing impact of key student and school factors on secondary school value-added effects
Authors: Li Lijuan , Kennedy Kerry John , Mok Magdalena Mo Ching 
Published: July 2016

Purpose
– The purpose of this paper is to establish and compare multilevel models that significantly predict school effects on adding value to their students regarding English reading from Secondary One to Secondary Six.

Design/methodology/approach
– The data were collected from 3,993 students within 66 schools in 2006 by the Educational Bureau of Hong Kong.

Findings
– When entering Secondary One, the students’ English reading ability was tested then again at Secondary Six. A range of value-added models were fitted to the data. The comparison across these models suggests that student individual scores at intake are the most powerful indicators of value-added. The intake aptitude test scores, aggregated to school level, and gender made no significant difference. At the individual level, student band was the significant predictor. School level effects were largely non-significant. Specific findings on value-added across the schools are visualized as evidence of the parsimony of the selected model.

Research limitations/implications
– Secondary data such as this while collected at one point in time nevertheless can still shed light on current policies and practices. It is particularly the case considering that the value-added effects system is still working in Hong Kong over decades but less examined academically.

Originality/value
– This study has produced some insights for stakeholders to identify influences on the value-added patterns.
Perceptions of higher education reform in Hong Kong: a glocalisation perspective
Authors: Lanford Michael 
Published: July 2016

Purpose
– In 2012, the eight UGC-funded higher education institutions in Hong Kong completed a multi-year process in which the majority of academic programmes were transformed from three-year to four-year undergraduate curricula to accommodate liberal arts education. The purpose of this paper is to discuss why stakeholders in Hong Kong felt that reforms were necessary and summarizes the implementation of these reforms. Afterwards, recent literature that has similarly addressed higher education reforms is reviewed. Finally, the results of a qualitative research study, grounded in glocalization theory, are presented and contextualized.

Design/methodology/approach
– This paper first draws upon policy documents, newspaper accounts, and other published primary sources for the review of Hong Kong’s educational reforms. Subsequently, an exploratory qualitative research design consisting of semi-structured interviews with 23 administrators and professors in Hong Kong is presented. These individuals are designated as “key informants”, as they gave presentations, made speeches, or were otherwise active in conceptualizing Hong Kong’s undergraduate educational reform on macro- and micro-levels.

Findings
– Four primary findings concerning educational reform in Hong Kong are highlighted. They include tensions between international benchmarking and internal value systems; confusion over multiple educational paradigms; the limited efficacy of outside speakers and leadership; and controversy over outcome-based assessment.

Originality/value
– First, recent educational reforms in Hong Kong’s higher education sector are summarized. Second, the implications of educational reforms for Hong Kong and glocalization theory are discussed. Third, conclusions that may resonate with educational reform processes in other international contexts are drawn.
Narcissistic consumers in retail settings
Authors: Naderi Iman , Paswan Audhesh K. 
Published: July 2016

Purpose
This study aims to investigate how narcissistic consumers perceive and respond to variations in price and store image in retail settings.

Design/methodology/approach
The data for this study were collected from a sample of 248 respondents who participated in an experiment with a 2 × 2 × 2 between-subjects design.

Findings
The findings show that while narcissists and non-narcissists do not differ in their perceptions of product quality, they show completely different behavioral intentions. For instance, narcissistic consumers ascribe more importance to store image than to product price, whereas price is more critical in non-narcissists’ decision-making.

Research limitations/implications
Using a young sample and only one product category (i.e. clothing) may affect the generalization of the findings. The inherent drawback of experiments (i.e. gaining internal validity at the cost of external validity) is another limitation of this work.

Practical implications
The construct of narcissism plays a critical role in the way people evaluate products’ symbolic value and ultimately decide to purchase goods from a store which has a certain type of image, including the expected price of the merchandise. Therefore, the findings of this study have significant managerial implications for critical areas of retail business such as segmentation using narcissism, store image management and merchandise pricing.

Originality/value
Despite a long history in social and clinical psychology, few empirical studies have examined narcissism and its impact on consumer behavior. The present study is an attempt to address this gap in retail settings and provides insights into the joint effects of product price and store image on narcissists’ purchase behavior.
Retrospective evaluations of playful experiences
Authors: Mukherjee Sayantani , Lau-Gesk Loraine 
Published: July 2016

PurposeThis paper aims to examine the impact of key affective moments of a playful experience on consumers’ overall retrospective evaluations.Design/methodology/approachThe authors build on past literature on hedonic psychology and sequential preferences and link it to specific characteristics of playful experiences to derive their hypotheses. The hypotheses are tested through two field experiments conducted at a videogame arcade.FindingsResults demonstrated that consumers’ overall evaluations are better aligned with the affective intensity at the final or end moment of a playful experience. Findings also revealed the complexity of understanding playful experiences, for it is the meaningfulness of end moments rather than simply their recent position in the experience that underlies overall evaluations. When end moments cease to be meaningful, the trough or least affective intense moment impacts overall evaluations.Practical implicationsThis research has implications for marketers who are deciding on which point of a playful experience to concentrate their resources for optimizing evaluations.Originality/valueThis research contributes to literature on playful consumption by illuminating how consumers rely on affective moments of a playful experience to construct overall evaluations. Additionally, it highlights the important role of meaningfulness of end moments, a relatively underexplored process, which extends literature on key moments and retrospective evaluations.