bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Diabatic Role of Ice Microphysical Processes in Two North Atlantic Summer Cyclones
Authors: Dearden C. , Vaughan G. , Tsai T. , Chen J.-P. 
Published: January 2016

AbstractNumerical simulations are performed with the Weather Research and Forecasting Model to elucidate the diabatic effects of ice phase microphysical processes on the dynamics of two slow-moving summer cyclones that affected the United Kingdom during the summer of 2012. The first case is representative of a typical midlatitude storm for the time of year, while the second case is unusually deep. Sensitivity tests are performed with 5-km horizontal grid spacing and at lead times between 1 and 2 days using three different microphysics schemes, one of which is a new scheme whose development was informed by the latest in situ observations of midlatitude weather systems. The effects of latent heating and cooling associated with deposition growth, sublimation, and melting of ice are assessed in terms of the impact on both the synoptic scale and the frontal scale. The results show that, of these diabatic processes, deposition growth was the most important in both cases, affecting the depth and position of each of the low pressure systems and influencing the spatial distribution of the frontal precipitation. Cooling associated with sublimation and melting also played a role in determining the cyclone depth, but mainly in the more intense cyclone case. The effects of ice crystal habit and secondary ice production are also explored in the simulations, based on insight from in situ observations. However in these two cases, the ability to predict changes in crystal habit did not significantly impact the storm evolution, and the authors found no obvious need to parameterize secondary ice crystal production at the model resolutions considered.
Evaluation of Autologous Fascia Implantation With Controlled Release of Fibroblast Growth Factor for Recurrent Laryngeal Nerve Paralysis Due to Long-term Denervation
Authors: Nagai Hiromi , Nishiyama Koichiro , Seino Yutomo , Tabata Yasuhiko , Okamoto Makito 
Published: January 2016

Objectives: Paralyzed tissue due to long-term denervation is resistant to many treatments because it induces irreversible histological changes and disorders of deglutition or phonation. We sought to determine the effect of autologous transplantation of fascia into the vocal fold (ATFV) with controlled release of basic fibroblast growth factor (bFGF) on long-term unilateral vocal fold paralysis (UVFP). Methods: Unilateral recurrent laryngeal nerve (RLN) section was performed on 20 rats. Five rats were implanted with autologous fascia only (fascia group), and 10 rats were implanted with autologous fascia and a gelatin hydrogel sheet with 1 μg (1 μg bFGF + fascia group) or 0.1 μg (0.1 μg bFGF + fascia group) of bFGF 4 months after RLN section. We evaluated the normalized glottal gap and laryngeal volume and histological changes 3 months after implantation. Results: The normalized glottal gap was significantly reduced in the 3 fascia implantation groups. Normalized laryngeal volume, fat volume, and lateral thyroarytenoid muscle volume were significantly increased in the 2 fascia implantation with bFGF groups. Conclusions: The ATFV with controlled release of bFGF repaired the glottal gap and laryngeal volume after RLN section and may reduce the occurrence of aspiration and hoarseness. We speculate that this treatment improves laryngeal function in long-term RLN denervation.
The World Bank’s approach to public sector management for 2011–2020: proposals to push forward the debate
Authors: Ngouo Léon Bertrand 
Published: January 2016

This article is a contribution to the debate raised in the special issue of the International Review of the International Institute of Administrative Sciences (IIAS) (Volume 79(3)) devoted to the World Bank’s approach to public sector management for 2011–2020. We offer a methodological framework for action that builds on the definitions we have chosen of three key concepts used by several authors: ‘administrative reform’, the ‘real world’ and the ‘performance’ of administrations. The proposed model suggests an inductive-style methodological approach, taking into account the challenges that the World Bank has set itself to secure the successful implementation of its strategy. Points for practitioners The success of administrative reforms very much depends on the consideration given to the different mechanisms that regulate the actual workflow in public services. The article shows how this flow is characterised by multiple methods of regulation whose nature and configuration vary from one administration to another, and offers a way of managing reforms that duly takes this into account. The focus is on the professionalism of the practitioners in this field.
Ghanaian Woman and Dutch Wax Prints: The Counter-appropriation of the Foreign and the Local Creating a New Visual Voice of Creative Expression
Authors: Young Paulette 
Published: January 2016

This essay explores the role of textiles, particularly Dutch wax prints, in the lives of women in Ghana, West Africa. Wax prints are colorful message-bearing printed cloths produced in Holland, based on Indonesian batik designs that express meaningful messages. Central to this discussion is the practice of counter-appropriation, that is, how women as individuals are in dialogue with culture by transferring the foreign, in this case Dutch wax prints, into the local in a culturally appropriate way. It positions women not only as cloth distributors and consumers, but also as producers of knowledge through the phenomenon of naming. This paper builds on the work of Professor George Clement Bond who, over a 20-year period, explored the impact of the movement of rural Yombe men of northern Zambia in search of wage employment and how this migration challenged their kin-based cults. Instead of rejecting capitalism, Yombe society members adjusted it to coexist with the ancestor cult. However, Yombe laborers did not merely appropriate money; by imbibing it with the spirits of the ancestors, they made it a new and meaningful form. In a similar vein, Ghanaian women culturally redefine factory printed textiles from a Dutch import by assigning them local meaning and value through the phenomenon of naming, resulting in an object accepted as foreign that is synthesized and indigenized into something that is meaningful and useful to them, becoming a “visual voice” for creative expression. This essay will show Dutch wax prints as a realm in which women play a key role not only as distributors and consumers, but also as producers of knowledge and of a new cultural form. It positions women as active participants in the global markets who have taken advantage of the economic opportunities offered by technological changes and the subsequent reordering of class relations of production.
Neurotensin: A role in substance use disorder?
Authors: Ferraro Luca , Tiozzo Fasiolo Laura , Beggiato Sarah , Borelli Andrea C , Pomierny-Chamiolo Lucyna , Frankowska Malgorzata , Antonelli Tiziana , Tomasini Maria C , Fuxe Kjell , Filip Malgorzata 
Published: January 2016

Neurotensin is a tridecapeptide originally identified in extracts of bovine hypothalamus. This peptide has a close anatomical and functional relationship with the mesocorticolimbic and nigrostriatal dopamine system. Neural circuits containing neurotensin were originally proposed to play a role in the mechanism of action of antipsychotic agents. Additionally, neurotensin-containing pathways were demonstrated to mediate some of the rewarding and/or sensitizing properties of drugs of abuse. This review attempts to contribute to the understanding of the role of neurotensin and its receptors in drug abuse. In particular, we will summarize the potential relevance of neurotensin, its related compounds and neurotensin receptors in substance use disorders, with a focus on the preclinical research.
Evaluation of Neuroleptic Utilization in the Intensive Care Unit During Transitions of Care
Authors: Gilbert Brian , Morales James R. , Searcy Randi J. , Johnson Donald W. , Ferreira Jason A. 
Published: January 2016

Purpose: The purpose of this study was to identify risk factors associated with inappropriate continuation of neuroleptics postdischarge from the intensive care unit (ICU) and hospital. Materials and Methods: A retrospective chart review was performed including all patients greater than 18 years of age who received neuroleptic medications in an ICU. Results: One hundred sixty-one patients were included during the 12- month study period. There were 85 (53%) patients discharged from the ICU with inappropriate continuation of a neuroleptic medication. There were 54 (34%) patients discharged from the hospital with inappropriate continuation of a neuroleptic medication. Patients were more likely to be discharged from the ICU with an inappropriate neuroleptic if they were prescribed multiple neuroleptics ( P = .02), did not have a urine drug screen collected at admission ( P = .023), or if trazodone was utilized in their therapy ( P = .004). Patients were more likely to be discharged from the hospital with a neuroleptic if they had multiple neuroleptic orders ( P = .0001) or if trazodone was utilized in their therapy ( P = .0023). Conclusion: Risk factors associated with the continuation of inappropriate neuroleptic medications upon discharge from the ICU or the hospital include multiple neuroleptic medications prescribed, the lack of a urine drug screen upon admission, and the utilization of trazodone.
Becoming a nurse as a moral journey: A constructivist grounded theory
Authors: Ranjbar Hadi , Joolaee Soodabeh , Vedadhir Abouali , Abbaszadeh Abbas , Bernstein Colleen 
Published: January 2016

Background: Nursing students, during their study, experience significant changes on their journey to become nurses. A major change that they experience is the development of their moral competency. Objective: The purpose of this study is to explore the process of moral development in Iranian nursing students. Research design: A constructivist grounded theory method was adopted. Twenty-five in-depth, semi-structured, face-to-face intensive interviews with 22 participants were conducted from September 2013 to October 2014. All interviews were audio-taped, transcribed, and analyzed using writing memos and the constant comparative method. Participants and research context: The setting was three major nursing schools within Tehran, the capital of Iran. Nineteen nursing students and three lecturers participated in the study. Ethical considerations: The study was approved by the Tehran University of Medical Sciences Committee for Medical Research Ethics (92/D/130/1781). It was explained to all participants that their responses would be treated with confidentiality and that they would not be identified in any way in the research and any publication ensuing from the research. All participants agreed to be interviewed and signed written consent forms agreeing to the recording and analyses of the interview data gathered. Findings: Findings indicated three levels of moral development along with the formation of professional identity. The three levels of moral development, getting to know the identity of nursing (moral transition), accepting nursing identity (moral reconstruction), and professional identity internalization (professional morality), were connected to the levels of professional identity formation. Discussion: The proposed model added a new insight to professionalism in nursing. Conclusion: From the findings, it was concluded that to enhance higher moral practice, nursing instructors should promote the professional identity of nursing students. Reinforcement of moral characteristics and professional identity within registered nurses occurs over a series of phases and, once fully integrated into the identity of nursing students, the moral characteristics that they acquire become part of their both professional and personal identities.
Mental health screening in immigration detention: A fresh look at Australian government data
Authors: Young Peter , Gordon Michael S 
Published: January 2016

Objectives: The poor mental health of asylum seekers and refugees in immigration detention has consistently been reported in peer-reviewed literature internationally; however, data on the mental health of asylum seekers and refugees detained in Australian immigration has been very limited. Methods: We re-analysed mental health screening data obtained by the Human Rights Commission. Results: Longer time in detention was associated with higher self-reported depression scores, with female individuals being more vulnerable to time in detention than those of male gender. Approximately one-half of the refugee group who agreed to complete the Harvard Trauma Questionnaire had post-traumatic stress disorder symptoms. On clinician-rated measures, one-third of the children, adolescents and adults suffered with clinical symptoms requiring tertiary outpatient assessment. Conclusions: This paper consolidates the findings of the 2014 Australian Human Rights Commission report and it provides an argument for public reporting of refugee data.
Effectiveness of Learning Through Experience and Reflection in a Project Management Simulation
Authors: Geithner Silke , Menzel Daniela 
Published: January 2016

Aim. In close cooperation with an international automotive supplier we developed the “C2” business simulation game in order to meet real work practice needs. Based on the example of a site-location decision and the setup of a new factory in China, the participants of the game experienced the challenges of an interdisciplinary project team as well as project management in complex and rapidly changing situations. During the game we used the creative learning method LEGO® Serious Play®,1 which helps to express different understandings through hands-on modelling. The aim of the game is to acquire and improve both technical project management knowledge and soft skills of the participants. Method. In total, 47 students participated in one of six two-day game sessions. They reported self-perceptions about their skill level through pre- and post-game questionnaires. Further data were collected during the simulation game based on observations, lessons learned reflections of the participants and evaluation questionnaires. Results. Results from our pre- and post-game self-assessment questionnaires show that the “C2” business simulation game improves not only conceptual knowledge about project management but also team working and the participants’ other soft skills. Results indicate that the students’ reactions to the simulation game were positive, and students felt that the LEGO Serious Play method helped them to better cope with challenges of teamwork, influences of stakeholders, risk factors and unpredictable project situations. Conclusion. These results suggest that our business simulation game has the potential to be an effective learning and training tool to provide students with relevant skills necessary for project managers. By giving students the opportunity to act in an authentic scenario based on a real project case, we can support their action-oriented as well as their trial-and-error learning, or in short their learning through experience.
Torsional Failure of Carbon Fiber Composite Plates Versus Stainless Steel Plates for Comminuted Distal Fibula Fractures
Authors: Wilson William K. , Morris Randal P. , Ward Adam J. , Carayannopoulos Nikoletta L. , Panchbhavi Vinod K. 
Published: January 2016

Background: Carbon fiber composite implants are gaining popularity in orthopedics, but with few independent studies of their failure characteristics under supra-physiologic loads. The objective of this cadaveric study was to compare torsional failure properties of bridge plating a comminuted distal fibula fracture with carbon fiber polyetheretherketone (PEEK) composite and stainless steel one-third tubular plates. Methods: Comminuted fractures were simulated in 12 matched pairs of fresh-frozen human fibulas with 2-mm osteotomies located 3 cm proximal to the tibiotalar joint. Each fibula pair was randomized for fixation and implanted with carbon fiber and stainless steel 5-hole one-third tubular plates. The constructs were loaded in external rotation at a rate of 1-degree/sec until failure with a materials testing system. Torsional stiffness and mode of failure, as well as displacement, torque, and energy absorption for the first instance of failure and peak failure, were determined. Statistical analysis was performed with paired t tests and chi-square. Results: There were no significant differences among the 12 pairs for torsional stiffness, first failure torque, peak failure displacement, peak failure torque, or peak failure energy. Stainless steel plates exhibited significantly higher displacement ( P < .001) and energy absorption ( P = .001) at the first indication of failure than the carbon fiber plates. Stainless steel plates permanently deformed significantly more often than the carbon fiber plates ( P = .035). Carbon fiber plates exhibited no plastic deformation with delamination of the composite, and brittle catastrophic failure in 1 specimen. Conclusions: In a comminuted human fibula fracture fixation model, carbon fiber implants exhibited multiple pre-peak failures at significantly lower angles than the first failure for the stainless steel implants, with some delamination of composite layers and brittle catastrophic failure rather than plastic deformation. Clinical relevance: The torsional failure properties of carbon fiber composite one-third tubular plates determined in this independent study provide novel in vitro data for this alternative implant material.
Retrospective evaluation of toceranib phosphate (Palladia) in cats with oral squamous cell carcinoma
Authors: Wiles Valerie , Hohenhaus Ann , Lamb Kenneth , Zaidi Bushra , Camps-Palau Maria , Leibman Nicole 
Published: January 2016

Objectives The aim of the study was to determine the clinical benefit and adverse event profile of toceranib phosphate in the treatment of feline oral squamous cell carcinoma (FOSCC). Methods Data obtained from the medical records of cats with oral squamous cell carcinoma diagnosed between 2010 and 2014 treated with toceranib phosphate were compared with medical record data from cats that did not receive toceranib, cytotoxic chemotherapy or radiation, to determine the response to toceranib treatment and adverse event profile of toceranib in cats. Concurrent use of non-steroidal anti-inflammatory drugs (NSAIDs) was allowed. Results Forty-six cats with FOSCC were included; 23 received treatment with toceranib (group 1) and 23 did not (group 2). The overall biological response rate in group 1 was 56.5%. Median survival time of toceranib-treated cats was significantly longer at 123 days compared with 45 days in cats not treated with toceranib ( P = 0.01). Cats achieving stable disease or better on toceranib therapy had significantly longer progression-free survival ( P <0.0001) and median survival ( P = 0.0042) times than those with progressive disease on toceranib. Administration of NSAIDs was also associated with significantly improved survival time ( P = 0.0038) among all cats. Anorexia was common but may reflect the underlying disease in these patients. Toceranib was well tolerated in cats, with the most common side effect being mild gastrointestinal toxicity. Conclusions and relevance Toceranib was well tolerated in cats with oral squamous cell carcinoma and may lead to improved survival times, especially when combined with NSAIDs. NSAID administration was also associated with improved survival times, and the relative benefit of toceranib and NSAIDs is difficult to determine from this retrospective study. Despite improvement in survival times, long-term survival in this patient population remained poor. As toceranib was well tolerated and may improve survival time, prospective evaluation of toceranib alone is warranted to assess response as a single agent and as part of multimodal therapy in an effort to achieve a more durable response in FOSCC.
Self-rated health in women prior to clinical onset of multiple sclerosis: A study within the Danish National Birth Cohort
Authors: Nielsen Nete Munk , Harpsøe Maria C. , Simonsen Jacob , Stenager Egon , Magyari Melinda , Koch-Henriksen Nils , Frisch Morten , Bager Peter 
Published: January 2016

Background: It has been suggested that onset of multiple sclerosis (MS) is preceded by a clinically silent period of up to 10 years. Objectives: Examine whether such a period should be associated with poor self-rated health (SRH). Methods: Information on SRH before pregnancy was ascertained among 80,848 women participating in the Danish National Birth Cohort (DNBC) 1996–2002. Women were followed for MS from enrolment in DNBC in the 16th week of pregnancy until 31 December 2011. Associations between SRH and MS were evaluated by means of hazard ratios (HR) with 95% confidence intervals (CIs) using Cox proportional hazard models. Results: During on average 11.7 years of follow-up, 239 women were diagnosed with MS. Overall, neither women with fair (HR = 1.09 (95% CI = 0.83–1.41), n = 113) nor poor pre-pregnancy SRH (HR = 0.94 (95% CI = 0.47–1.87), n = 9) were at an increased risk of MS compared with women reporting very good pre-pregnancy SRH. Supplementary analyses showed no significant differences in MS risk in consecutive periods of follow-up. Conclusion: In this first prospective cohort study assessing MS risk as a function of SRH, we found no indication of a long period of poor SRH prior to MS. Our findings based on pregnant women may not necessarily apply to all women.
RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis
Authors: Mori Francesco , Nisticò Robert , Nicoletti Carolina G , Zagaglia Sara , Mandolesi Georgia , Piccinin Sonia , Martino Gianvito , Finardi Annamaria , Rossini Paolo M , Marfia Girolama A , Furlan Roberto , Centonze Diego 
Published: January 2016

Background: Alterations of synaptic transmission induced by inflammatory activity have been linked to the pathogenic mechanisms of multiple sclerosis (MS). Regulated upon activation, normal T-cell expressed, and secreted (RANTES) is a pro-inflammatory chemokine involved in MS pathophysiology, potentially able to regulate glutamate release and plasticity in MS brains, with relevant consequences on the clinical manifestations of the disease. Objective: To assess the role of RANTES in the regulation of cortical excitability. Methods: We explored the association of RANTES levels in the cerebrospinal fluid (CSF) of newly diagnosed MS patients with magnetic resonance imaging (MRI) and laboratory measures of inflammatory activity, as well its role in the control of cortical excitability and plasticity explored by means of transcranial magnetic stimulation (TMS), and in hippocampal mouse slices in vitro. Results: CSF levels of RANTES were remarkably high only in active MS patients and were correlated with the concentrations of interleukin-1β. RANTES levels were associated with TMS measures of cortical synaptic excitability, but not with long-term potentiation (LTP)-like plasticity. Similar findings were obtained in mouse hippocampal slices in vitro, where we observed that RANTES enhanced basal excitatory synaptic transmission with no effect on LTP. Conclusion: RANTES correlates with inflammation and synaptic excitability in MS brains.