bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymmetric temperature effect on leaf senescence and its control on ecosystem productivity
Authors: He Lei , Wang Jian , Peñuelas Josep , Zohner Constantin M , Crowther Thomas W , Fu Yongshuo , Zhang Wenxin , Xiao Jingfeng , Liu Zhihua , Wang Xufeng , Li Jia-Hao , Li Xiaojun , Peng Shouzhang , Xie Yaowen , Ye Jian-Sheng , Zhou Chenghu , Li Zhao-Liang 
Published: October 2024

Abstract
Widespread autumn cooling occurred in the northern hemisphere (NH) during the period 2004–2018, primarily due to the strengthening of the Pacific Decadal Oscillation and Siberian High. Yet, while there has been considerable focus on the warming impacts, the effects of natural cooling on autumn leaf senescence and plant productivity have been largely overlooked. This gap in knowledge hinders our understanding of how vegetation adapts and acclimates to complex climate change. In this study, we utilize over 36,000 in situ phenological time series from 11,138 European sites dating back to the 1950s, and 30 years of satellite greenness data (1989–2018), to demonstrate that leaf senescence dates (LSD) in northern forests responded more strongly to warming than to cooling in autumn. Specifically, a 1 °C increase in temperature caused 7.5 ± 0.2 days' delay in LSD, whereas a 1 °C decrease led to an advance of LSD with 3.3 ± 0.1 days (P &lt; 0.001). This asymmetry in temperature effects on LSD is attributed to greater preoverwintering plant-resource acquisition requirements, lower frost risk, and greater water availability under warming than cooling conditions. These differential LSD responses highlight the nonlinear impact of temperature on autumn plant productivity, which current process-oriented models fail to accurately capture. Our findings emphasize the need to account for the asymmetric effects of warming and cooling on leaf senescence in model projections and in understanding vegetation–climate feedback mechanisms.
It’s Not Just Trump: Americans of Both Parties Support Liberal Democratic Norm Violations More Under Their Own President
Authors: Littvay Levente , McCoy Jennifer L , Simonovits Gabor 
Published: October 2024

Abstract
There is a growing worry about the health of American democracy, and political scientists and pundits alike are looking for possible explanations. Surveys conducted during the Trump presidency showed considerable citizen support for liberal democratic norm erosions, especially among Republicans. However, recent experimental research also shows that voters of both parties are more tolerant of norm erosion committed by politicians of the party they prefer. In this note, we aim to reconcile these contradictory findings by analyzing surveys spanning from 2006 to 2021 on the public’s tolerance of executive concentration of power. We also collect original data under both the Trump and Biden administrations gauging support for a broad array of liberal democratic norm erosions. Support for such erosions, in fact, has been relatively similar across Democrats and Republicans once we account for the party of the president. Support for executive aggrandizement has been prevalent among supporters of the president’s party at least since the second term of the Bush administration. Increased checks and balances on the executive, through divided government, amplifies this effect further. Taken together, these findings suggest that universal support for the liberal democratic status quo has been weaker among those who support the president’s party, well before and since the Trump presidency.
Formulas for Autocratic Stability: A Review Article
Authors: Huang Min-Hua , Huang Osbern , Kuo Chi-Hsien 
Published: October 2024

Abstract
Drawing on the analytical framework of Johannes Gerschewski's The Two Logics of Autocratic Rule, we explore the complexities of autocratic stability by examining the mechanisms through which autocrats preserve their regimes. We review Gerschewski's data set and arguments and provide our assessment regarding the empirical validity of Gerschewski's theory and tests. While Gerschewski's two logics of autocratic rule offer insightful understandings, the role of situational dynamics, international intervention, and political succession in influencing autocratic stability are underrated or neglected. The survival of an autocratic regime is not solely based on the prevention and preemption of challenges from political opponents, but also depends on the performance of regular governance functions along with a monopoly of political power and the resolution of leadership issues. The path-dependent nature of autocratic stability requires analysis of autocratic regime subtypes to effectively contextualize and generalize the patterns of political succession under different logics of autocratic rule. Lacking a comprehensive characterization of autocratic subtypes, the main contribution of Gerschewski's book is more theoretical than empirical.
Firm Inattention and the Efficacy of Monetary Policy: A Text-Based Approach
Authors: Song Wenting , Stern Samuel 
Published: October 2024

Abstract
This paper provides empirical evidence of the importance of firm attention to macroeconomic dynamics. We construct a text-based measure of attention to macroeconomic news and document that attention is polarized across firms and countercyclical. Differences in attention lead to asymmetric responses to monetary policy: expansionary monetary shocks raise the market values of attentive firms more than those of inattentive firms, and contractionary shocks lower the values of attentive firms by less. Attention also mitigates the effects of macroeconomic uncertainty on firm performance. In a quantitative rational inattention model that is calibrated with this new text-based measure, inattention drives monetary non-neutrality. As average attention varies over the business cycle, so does the efficacy of monetary policy.
Efficacy and Safety of Lenvatinib in Combination With Other Tyrosine Kinase Inhibitors for Metastatic Renal Cell Carcinoma
Authors: Jamil Abdur , Qureshi Zaheer , Siddique Rimsha , Altaf Faryal , Akram Hamzah 
Published: October 2024

Objective:
This meta-analysis evaluates the efficacy and safety of lenvatinib, both as monotherapy and in combination with other (tyrosine kinase inhibitors) TKIs, compared with other TKIs in metastatic renal cell carcinoma (RCC) treatment.

Methods:
We searched for relevant studies from inception to February 2024 using PubMed, Web of Science, Cochrane Library, and Scopus. Eligible studies reported on the efficacy and safety of lenvatinib alone or in combination with other TKIs versus other TKIs for metastatic RCC. Primary outcomes included progression-free survival (PFS) and overall survival (OS). Secondary outcomes included objective response rate (ORR), adverse events (AEs), and health-related quality of life (HRQOL).

Results:
Seventeen studies met the inclusion criteria. Lenvatinib, especially in combination therapies, significantly improved PFS (HR: 0.46, 95% CI: 0.38-0.54, P<0.001) and OS (HR: 0.80, 95% CI: 0.70-0.91, P<0.001) compared with other TKIs. Quality of life analyses showed mixed results, with EQ-5D demonstrating significant improvement (HR: 1.21, 95% CI: 0.90-1.53, P<0.001), while EORTC QLQ-C30 was not statistically significant. ORR analysis indicated a higher likelihood of achieving a complete or partial response with lenvatinib (OR: 2.04, 95% CI: 1.15-2.93, P=0.00). The analysis of total AEs above grade 3 showed no significant difference between lenvatinib and other TKIs (OR: -0.08, 95% CI: -0.21 to 0.06, P=0.26).

Conclusions:
Lenvatinib significantly enhances survival outcomes in metastatic RCC patients compared with other TKIs. While associated with various adverse events, its safety profile is comparable to other TKIs.
An Assessment and Comparison of Adverse Effect Rates in Differing Absorbable Thread Lift Suture Materials
Authors: Ojha Avaneesh Sean , Farahbakhsh Navid , Saikaly Sami K. 
Published: October 2024

BACKGROUND
Thread lifting, a minimally invasive alternative to facial rhytidectomy, has shifted from using nonabsorbable to absorbable sutures. Although many thread lift options exist, the impact of these different properties on complication rates remains unclear.

OBJECTIVE
To systematically compare thread lift complication rates across different suture materials, textures, fixation methods, and lift locations.

MATERIALS/METHODS
A systematic review was conducted through February 2024, following PRISMA guidelines, using multiple databases. The study focused on absorbable sutures, excluding nonabsorbable materials. Statistical analysis used Chi-Square tests with Bonferroni correction.

RESULTS
Nineteen studies, encompassing 1,406 patients, met inclusion criteria. A total of 876 complications were reported. Ecchymosis (19.49%), swelling (16.79%), and tenderness (9.96%) were the most frequent complications, while hematoma (0.64%), paresthesia (1.14%), and infection (2.49%) were least frequent. Complications varied significantly among the studied factors. Swelling and ecchymosis were more associated with polycaprolactone sutures, barbed threads, and midface lifts. Barbed threads were associated with more complications than smooth or coned threads, as were floating threads compared with fixed threads.

CONCLUSION
Variations in thread lift suture materials and fixation technique were associated with different complication rates. Thread lifts using absorbable sutures exhibited complication rates under 5%, suggesting a generally favorable safety profile.
Low-Field MRI for Dental Imaging in Pediatric Patients With Supernumerary and Ectopic Teeth
Authors: Willershausen Ines , Evangeliou Stefania , Fautz Hans-Peter , Amarteifio Patrick , May Matthias Stefan , Stroebel Armin , Zeilinger Martin , Uder Michael , Goelz Lina , Kopp Markus 
Published: October 2024

Objectives
This study sought to elucidate the diagnostic performance of 0.55 T magnetic resonance imaging (MRI) for pediatric dental imaging, specifically in terms of the image quality (IQ) for detecting ectopic and/or supernumerary teeth, compared with routine ultra-low-dose computed tomography (ULD-CT) of the jaw.

Materials and Methods
A total of 16 pediatric patients (mean age: 12.4 ± 2.6 years, range: 9–17 years) with ectopic and/or supernumerary teeth screened from January 2023 to January 2024 were enrolled in this prospective, single-center study. All patients underwent ULD-CT as the clinical reference standard and 0.55 T MRI as the study scan on the same day. A 0.6-mm isotropic 3-dimensional T1w FLASH sequence was developed with a dedicated field of view of the upper and lower jaws. ULD-CT was performed using a new single-source computed tomography (CT) scanner equipped with a tin filter (Sn100, slice thickness: 1 mm, quality reference mAs: 24). The IQ for the tooth axis, the tooth length, the tooth root, root resorptions, cysts, the periodontal ligament space, and the mandibular canal was evaluated twice by 3 senior readers using a 5-point Likert scale (LS) (LS score of 1: insufficient, 3: reduced IQ but sufficient for clinical use, and 5: perfect) and compared between both methods. Subsequently, the results were dichotomized into nonvalid (LS score of ≤2) and valid (LS score of ≥3) for clinical use.

Results
A total of 49 ectopic and/or supernumerary teeth in 16 pediatric patients were investigated using ULD-CT (CTDI: 0.43 ± 0.09 mGy) and 0.55 T MRI. The mean MRI acquisition time was 9:45 minutes. Motion artifacts were nonsignificantly different between 0.55 T MRI and ULD-CT (P = 0.126). The IQ for the tooth axis, the tooth root, root resorptions, and cysts was similar between the methods. The IQ for the periodontal ligament space and tooth length favored ULD-CT by 14% (confidence interval [CI]: 4.3%–24%) and 7.5% (CI: 1.8%–13%), respectively, whereas that for the mandibular canal favored 0.55 T MRI by −35% (CI: −54%–16%). Sufficient IQ was found especially for cystic lesions (CT: 100% sufficient, MRI: 95% sufficient), the tooth root (CT: 100%, MRI: 98%), root resorptions (CT: 94%; MRI: 85%), the tooth axis (CT: 100%; MRI: 98%), and the tooth length (CT: 99%; MRI: 91%).

Conclusions
The findings indicate that 0.55 T MRI is a feasible, radiation-free technique for delineating ectopic and/or supernumerary teeth in pediatric patients. Nevertheless, to date, 0.55 T MRI has not yet been able to provide an optimal IQ for all anatomical tooth and jaw structures. In cases of advanced clinical indications that require optimal spatial resolution, high-resolution CT or cone-beam CT may still be necessary.
High 18F-FDG Uptake in Phosphoglyceride Crystal Deposition Disease of the Humerus Mimicking Chondrosarcoma
Authors: Matsutani Hiroki , Komori Tsuyoshi , Baba Ichiro , Kurisu Yoshitaka , Yamamoto Kazuhiro , Osuga Keigo 
Published: October 2024

Abstract
A 82-year-old man presented with left humerus pain. MRI revealed a lesion in the left humerus appearing hyperintense on T2WI and hyperintense on DWI. 18F-FDG PET/CT demonstrated high FDG uptake in the lesion. Surgical resection was performed under the preoperative diagnosis of chondrosarcoma. However, a histopathological analysis confirmed the diagnosis of phosphoglyceride crystal deposition disease (PGDD). PGDD is an extremely rare disease, and this is the first report of PGDD occurring in the humerus. Bone lesions showing high uptake of FDG are usually malignant lesions; however, it is important to consider the possibility of benign diseases such as PGDD.
18F-FDG PET/CT Findings of Isolated Renal Metastasis From Squamous Cell Lung Cancer
Authors: Yu Jun , Li Yang , Yang Xue , Ren Dongdong , Chen Cong 
Published: October 2024

Abstract
We present the 18F-FDG PET/CT findings of a 64-year-old man with isolated renal metastasis. He had a history of radical surgery for squamous cell lung cancer 14 months ago, followed by chemotherapy and immunotherapy. The renal metastasis presented as a small focus of increased FDG uptake in the restaging 18F-FDG PET/CT scan, which was regarded as renal cortical tracer retention. The renal metastasis was more prominent on the second PET/CT performed 5 months later. The patient subsequently underwent radical nephrectomy, and histopathological examination confirmed the diagnosis of renal squamous cell carcinoma metastasis.
Identification of a Regenerative Protocol for Recellularizing Human Auricular Cartilage Scaffolds
Authors: Ziegler Mary E. , Alaniz Leonardo , Khan Nawal , Lem Melinda , Pham Jason , Sherafat Arya , Melkonian Jacklyn , Prabhakar Nikhil , Shay Madelyn , Oyur Kadir B. , Pfaff Miles J. , Widgerow Alan D. 
Published: October 2024

Objective
Utilizing biological scaffolds for cartilage tissue engineering is a promising tool for improving auricular reconstruction. Decellularized auricular scaffolds provide a means of regenerating cartilage for in vivo implantation, but identifying the ideal regenerative mix remains challenging.

Methods
Human cadaver auricular cartilage was decellularized and recellularized with either auricular chondrocytes alone, auricular chondrocytes with adipose-derived stem cells, or both cells with platelet-rich plasma. Confirmation of decellularization and recellularization was done by hematoxylin and eosin staining. Extracellular matrix preservation and production were determined by Masson's trichrome, Alcian blue, and Verhoeff-van Gieson staining. Collagen II assessments were made using immunohistochemistry.

Results
Decellularization of cadaver auricular cartilage was confirmed by the absence of cells, reduction in glycosaminoglycans, and the preservation of collagen and elastin. Recellularization was more efficient when chondrocytes were seeded with adipose-derived stem cells, which was enhanced by adding platelet-rich plasma. Coculture with platelet-rich plasma yielded better total collagen (56% increase) and glycosaminoglycan (47% increase) induction. Moreover, when platelet-rich plasma was added, collagen II induction was significantly increased (42%; P < 0.05).

Conclusion
We identified a regenerative protocol that included auricular chondrocytes, adipose-derived stem cells, and platelet-rich plasma, which stimulated chondrogenesis on decellularized auricular cartilage. This finding provides a model to explore cartilage formation and the potential for improving auricular and cartilage-based reconstruction.
Fucoidan-Copper Nanoparticles to Potentiate Synergistic Cancer Cell Cuproptosis and Immunotherapy
Authors: Chen Hao-Hong , Pang Xiao-hui , Wang Qian-hui , Chen Ziye , Zhuang Li-li , Luo Jia-yuan , Zheng Qian-xi , Zhong Rui-fang , Zhan Xiao-mei , Yang Li , Zhu Liang , Jiang Jian-Guo 
Published: October 2024

AbstractCuproptosis, a newly characterized form of regulated cell death initiated by copper binding to lipoylated components of the tricarboxylic acid cycle, presents a promising target for cancer therapy. Here, we report the development of fucoidan-copper nanoparticles (Fu-Cu) that exploit this mechanism to selectively induce cytotoxicity in HuH-7 liver cancer cells. The Fu-Cu was synthesized using fucoidan, a sulfated polysaccharide with inherent anticancer properties, as a natural nanocarrier for copper ions. Characterization confirmed successful copper incorporation and the formation of stable nanoparticles. Fu-Cu treatment enhanced intracellular copper levels and oxidative stress, triggering cuproptosis mediated by mitochondrial carrier homolog 2. Knockout of ferredoxin 1 in HuH-7 cells mitigated the cytotoxic effects, underscoring its critical role in copper-induced cell death. Invivostudies using a subcutaneous tumor model in BALB/c nude mice demonstrated that Fu-Cu effectively inhibited tumor growth and stimulated antitumor immunity, evidenced by increased infiltration of T cells, natural killer cells, and macrophages within the tumor microenvironment. These findings highlight Fu-Cu as a novel therapeutic strategy for HCC, leveraging the mechanism of cuproptosis and immune activation to suppress tumor progression.
The protease interpain A ofPrevotella intermediapromotes human OSCC cells proliferation and migration
Authors: Chang Szu-Min , Huang I-Hsiu , Ciou Yun-Jhen , Wang Wen-Rong , Wu Ni-Hung , Chuu Chih-Pin , Hsiao Jenn-Ren , Chang Jeffrey S , Chang Jang-Yang , Chen Jenn-Wei 
Published: October 2024

AbstractBackgroundOral squamous cell carcinoma (OSCC) is a prevalent cancer worldwide. Oral microbiota dysbiosis causes periodontal diseases and may lead to OSCC. The oral microbiome analysis has indicated that the oral pathogen Prevotella intermedia was more abundant in OSCC patients than in healthy people. Therefore, we investigated the roleP. intermediaplayed during OSCC carcinogenesis.MethodsHuman oral epithelial cell line SG as well as OSCC cell lines SCC-15 and SAS were treated withP. intermediaconditioned medium (CM). Effect of CM on migration of SCC-15 and SAS cells were examined by wound healing assay and transwell assay. We testedP. intermediain the colorectal cancer mouse model.ResultsCM ofP. intermediaATCC 25611 CM increased cell proliferation of SG, but the CM from clinical strains didn’t affect cell proliferation. Comparing the CM proteins composition of cell proliferation-promoting strain ATCC 25611 with other strains, interpain A (InpA) appeared to be the potential key factor promoting cell proliferation. InpA is a cysteine protease secreted byP. intermediaand might activate proteinase-activated receptor-2 (PAR-2) signaling pathway. SG cell proliferation was inhibited by adding protease inhibitor E64 or PAR-2 antagonist (FSLLRY-NH2). This phenomenon was also observed in SCC-15 and SAS cells. Additionally, InpA promoted migration of SCC-15 and SAS cells, and enhancement was inhibited by E64 or FSLLRY-NH2.P. intermediaincreased colorectal tumors development in murine model.ConclusionOur results identified InpA as a potential key virulence factor secreted highly by some oral microbiota, such as ATCC 25611. These strains may, therefore, play a role in OSCC development via regulation of PAR-2 signaling pathway.
The impact of neighborhood factors on exercise capacity in children with hypertrophic cardiomyopathy
Authors: Masood Imran R. , Wang Lei , Stanley Helen M. , Edwards Jonathan J. , Ahmed Humera , Lin Kimberly Y. , Wittlieb-Weber Carol A. , O’Connor Matthew J. , Rossano Joseph W. , O’Malley Shannon , Paridon Stephen , Tam Vicky W. , Edelson Jonathan B. 
Published: October 2024

AbstractBackgroundRestricting certain patients with hypertrophic cardiomyopathy (HCM) from exercise likely has negative cardiovascular effects and may not reduce the risk of sudden cardiac death. Promoting exercise in children with HCM is complex and requires knowledge of the environmental factors that impact exercise capacity in children with HCM.MethodsThis retrospective, cross-sectional analysis includes children with HCM who underwent exercise stress testing (EST) at a single, children’s tertiary-care center between 2000 and 2023. Addresses from contemporaneous EST were accessed and geocoded to census tracts. The Child Opportunity Index (COI) was the primary exposure of interest. Granular neighborhood measures including walkability index, Rural-Urban Commuting Area Codes (RUCA), Index of Concentration at the Extremes and Uniform Crime Reporting rates were measured. The primary outcome measure was peak oxygen consumption (VO2). Linear regression and multivariable analyses were performed.ResultsA total of 155 patients were identified who met inclusion criteria, 23% (n=35) of whom were female. Mean age at time of EST was 15.8 ±3.1 years. More than half of included patients were from high or very high COI (30%, n=46, and 35%, n=54, respectively). Most patients lived in urban environments (RUCA score 1 or 2, 96.7%, n=150). The mean peak VO2was 2159 ±906 milliliters/min and adjusted peak VO235.5 ±9.3 mL/kg/min. A multivariate model adjusting for disease severity, age at diagnosis of HCM, race and accounting for collinearity, showed that low COI, higher levels of urbanization and lower concentration of neighborhood wealth were independently associated with lower peak VO2.DiscussionOur study identified previously unrecognized environmental determinants of exercise capacity in children with HCM, with lower COI, increased urbanization, and lower neighborhood wealth independently associating with lower exercise performance. Programs designed to increase physical activity levels and exercise performance in children with HCM should account for neighborhood and economic factors.