bluuebunny/crossref_metadata_2025_split huggingface dataset:
A focused supply chain strategy for luxury fashion management
Authors: Brun Alessandro , Castelli Cecilia , Karaosman Hakan 
Published: August 2017

Purpose
Globalization and advanced manufacturing capabilities changed industrial dynamics. To this end, not only were new retail concepts developed to broaden the distribution toward larger consumer bases, but alternative ways were also sought to reorganize supply networks for a balance between local and global production. Yet, the choice of supply network configurations must be coherent with a fashion companies’ critical success factors. Hence, it is pivotal to understand how such large brand portfolios and global supply networks could be effectively managed in a united way. In this vein, the purpose of this paper is to explain how the triplet of product, brand, and retail channel could affect SC performance, and how the positioning of a luxury company could depend on managerial attitudes.

Design/methodology/approach
Subsequent to an extensive literature review, 30 most frequently quoted key performance indicators (KPIs) were derived. A Delphi study was then employed to reach a consensus and 17 key KPIs were derived considering the key SC performance areas and marketing dimensions. Survey technique was deployed to examine the impact of strategic combinations of product, brand, and retail channel on SC strategy. Survey results were analyzed through factor analysis where five principal components emerged to represent performance areas. ANOVA technique was then employed to explore the dependence between product-brand-retail channel and key performance areas.

Findings
Brand, retail channel, and product directly affect operational performance. The positioning of a fashion company would depend on its management attitude toward strategy segmentation and considered stage of the SC. The respondents’ profile analysis further showed a preference to segment the SC based on products. Interestingly, this finding is not aligned with earlier research (Brun and Castelli, 2008) suggesting that the brand was to become the most relevant driver for SC segmentation.

Originality/value
Academic development and empirical testing is rather rare in the luxury fashion context. Undeniably, SC strategies represent a very relevant issue for fashion companies, and the present study could be considered a first statistical step toward SC segmentation for luxury fashion companies.
The value relevance of environmental performance: evidence from Indonesia
Authors: Sarumpaet Susi , Nelwan Melinda Lydia , Dewi Dian Nirmala 
Published: August 2017

Purpose
This paper aims to extend previous developed market-based research on the value relevance of environmental performance by testing the relationship between share prices of Indonesian-listed corporations and their environmental performance ratings.

Design/methodology/approach
The sample consists of 60 listed firms which are rated by the Indonesia Ministry of Environment between 2002 and 2012, resulting in a sample of 246 observations. The Ohlson (1995) model was utilized and modified by including environmental ratings.

Findings
The research finds that superior environmental performance is associated with higher share price, whereas inferior environmental performance is value irrelevant to the market.

Research limitations/implications
Considering the significance of PROPER, this research did not observe other types of corporate environmental performance, such as those released by the press and reported in the company annual reports and websites. These limitations are not controlled for in the tests, and this might confound inferences.

Originality/value
The paper addresses a gap in the literature by providing insight on how a developing capital market values both superior and inferior environmental performance. It also provides implication on the effectiveness of environmental monitoring policy in providing incentives for firms to improve their environmental performance
Involving relatives in emergency psychiatry: an observational patient‐control study in a crisis resolution and home treatment team
Authors: van Oenen Flip Jan , Schipper Suzy , Van Rien , Visch Irene , Peen Jaap , Cornelis Jurgen , Schoevers Robert , Dekker Jack 
Published: August 2017

AbstractThe involvement of relatives is seen as an important element of treatment in crisis resolution and in home treatment teams. The aim of the study was to investigate the effects of involving relatives in treatment during a crisis situation. The outcomes for patients from a relatives‐involved group (RIG) and relatives‐not‐involved group (RNIG) were compared. Relatives were provided with general information about the service and assessments, psycho‐education and, in some cases, additional family interventions. Relatives were involved in the treatment of 168 of 263 patients (64 per cent). There were no significant differences between the RIG and RNIG in terms of mean scores for BSI at T12. The involvement of relatives was achieved in the majority of cases. No link with outcomes was found. Since involvement of relatives was not randomized and the number and duration of contacts with relatives were limited, these findings should be interpreted cautiously.Practitioner points

Using a structured motivational model, it is possible to involve relatives in the treatment of psychiatric crisis patients in the majority of cases
There is no reason to be reticent about involving relatives in treatment, even if patients seem to be reluctant at first sight
Living alone was in this study identified as a negative predictor of family involvement
External hyphae of Rhizophagus irregularis DAOM 197198 are less sensitive to low pH than roots in arbuscular mycorrhizae: evidence from axenic culture system
Authors: Wang Ning , Feng Zengwei , Zhou Yang , Zhu Honghui , Yao Qing 
Published: August 2017

SummaryThe growth of plant roots and arbuscular mycorrhizal fungi (AMF) can be inhibited by low pH; however, it is largely unknown which is more sensitive to low pH. This study aimed to compare the physiological and molecular responses of external hyphae (EH) and roots to low pH in terms of growth, development and functioning. We established AM symbiosis in a two‐compartmented system (root compartment, RC; hyphal compartment, HC) using AMF and transformed hairy roots and exposed them to pH 6.5 and/or pH 4.5. The results showed that pH 4.5 significantly decreased root cell viability, while EH at pH 6.5 attenuated the effect. In either RC or HC, pH 4.5 reduced biomass, P content, colonization, ALP activity in roots, and ALP activity and polyphosphate accumulation in EH. GintPT expression in EH was inhibited by pH 4.5 in HC but not in RC. The expression of mycorrhiza‐responsive LePTs was significantly reduced by the lower colonization due to decreased pH in either RC or HC, while the expression of non‐mycorrhiza‐responsive LePTs was not affected. Variation partitioning analysis indicated that EH was less sensitive to low pH than roots. The interactions between roots and EH under low pH stress merit further investigation.
Assessing the sustainability of Waiwai subsistence hunting in Guyana by comparison of static indices and spatially explicit, biodemographic models
Authors: Shaffer C. A. , Yukuma C. , Marawanaru E. , Suse P. 
Published: August 2017

AbstractWhile bushmeat hunting is critical to the livelihoods of millions of people throughout the tropical world, it is also a major threat to wildlife conservation. Assessing the sustainability of hunting has been a major goal in conservation biology but developing methods that accurately predict patterns of prey depletion has proven notoriously problematic. In this study, we sought to assess the sustainability of the hunting of indigenous Waiwai in Guyana by comparing results from the most commonly used static sustainability index, the production model, with results from spatially explicit biodemographic models for three indicator species; tapirsTapirus terrestris, spider monkeysAteles paniscus, and curassowsCrax alector. Our goals were to (1) assess how conclusions about sustainability differ between the two methods and (2) to determine the suitability of biodemographic modeling for nonprimate taxa. We used hunter‐self monitoring data to calculate annual harvest and to estimate parameters for biodemographic models. The production model indicated that all three species were being overharvested, withT. terrestrisharvested at six times the sustainable rate. In contrast, biodemographic models indicated that each species would persist in the Waiwai catchment area in 20 years (althoughA. paniscuswould be close to extirpation), even if the Waiwai population increased by 64% and shifted to all shotgun hunting. Predicted densities forA. paniscusandC. alectorwere statistically indistinguishable from empirically derived encounter rates and those forT. terrestriswere consistent with the locations of Waiwai kills, demonstrating the robustness of the model. While the weaknesses of static sustainability indices are well documented, they continue to be used and conclusions based on their results are still cited and influential in determining conservation policy. Our study demonstrates that biodemographic models perform far better than static indices and that the biodemographic approach is robust for a range of different prey species.
Development and Evaluation of Heartbeat: A Machine Perfusion Heart Preservation System
Authors: Li Yongnan , Zeng Qingdong , Liu Gang , Du Junzhe , Gao Bingren , Wang Wei , Zheng Zhe , Hu Shengshou , Ji Bingyang 
Published: August 2017

AbstractStatic cold storage is accompanied with a partial safe ischemic interval for donor hearts. In this current study, a machine perfusion system was built to provide a better preservation for the donor heart and assessment for myocardial function. Chinese mini‐swine (weight 30–35 kg, n = 16) were randomly divided into HTK, Celsior, and Heartbeat groups. All donor hearts were respectively preserved for 8 hours under static cold storage or machine perfusion. The perfusion solution is aimed to maintain its homeostasis based on monitoring the Heartbeat group. The ultrastructure of myocardium suggests better myocardial protection in the Heartbeat group compared with HTK or Celsior‐preserved hearts. The myocardial and coronary artery structural and functional integrity was evaluated by immunofluorescence and Western blots in the Heartbeat. In the Heartbeat group, donor hearts maintained a high adenosine triphosphate level. Bcl‐2 and Beclin‐1 protein demonstrates high expression in the Celsior group. The Heartbeat system can be used to preserve donor hearts, and it could guarantee the myocardial and endothelial function of hearts during machine perfusion. Translating Heartbeat into clinical practice, it is such as to impact on donor heart preservation for cardiac transplantation.
The molecular mechanism underlying unconventional secretion of Fibroblast Growth Factor 2 from tumour cells
Authors: Steringer Julia P. , Nickel Walter 
Published: August 2017

AbstractFibroblast Growth Factor 2 (FGF2) is a potent cell survival factor involved in tumour‐induced angiogenesis. FGF2 is secreted from cells through an unconventional secretory mechanism based upon direct translocation across the plasma membrane. The molecular mechanism underlying this process depends on a surprisingly small set of trans‐acting factors that are physically associated with the plasma membrane. FGF2 membrane translocation is mediated by the ability of FGF2 to oligomerise and to insert into the plasma membrane in a PI(4,5)P2‐dependent manner. Membrane‐inserted FGF2 oligomers are dynamic translocation intermediates that are disassembled at the extracellular leaflet mediated by membrane proximal heparan sulphate proteoglycans. This process results in the exposure of FGF2 on cell surfaces as part of its unconventional mechanism of secretion. Although the trans‐acting factors and cis‐elements in FGF2 required for unconventional secretion have been known for a while, the core mechanism of this mysterious process has now been reconstituted with purified components establishing the molecular basis of FGF2 secretion from tumour cells.
Discovery and pharmacological characterization of a novel series of highly selective inhibitors of cyclin‐dependent kinases 4 and 6 as anticancer agents
Authors: Tadesse Solomon , Bantie Laychiluh , Tomusange Khamis , Yu Mingfeng , Islam Saiful , Bykovska Nataliya , Noll Benjamin , Zhu Ge , Li Peng , Lam Frankie , Kumarasiri Malika , Milne Robert , Wang Shudong 
Published: August 2017

Background and PurposeCyclin D‐dependent kinases 4 and 6 (CDK4/6) are crucial regulators of the G1 to S phase transition of the cell cycle and are actively pursued as therapeutic targets in cancer. We sought to discover a novel series of orally bioavailable and highly selective small molecule inhibitors of CDK4/6.Experimental ApproachThe discovery of pharmacological inhibitors and optimization for potency, selectivity and drug properties were achieved by iterative chemical synthesis, biochemical screening against a panel of kinases, cell‐based assays measuring cellular viability, cell cycle distribution, induction of apoptosis and the level of retinoblastoma tumour suppressor protein (Rb) phosphorylation and E2 factor (E2F)‐regulated gene expression and in vitro biopharmaceutical and in vivo pharmacokinetic profiling.Key ResultsWe discovered several lead compounds that displayed >1000‐fold selectivity for CDK4/6 over other members of the CDK family. The lead compounds, 82, 91 and 95, potently inhibited the growth of cancer cells by inducing G1 arrest with a concomitant reduction in the phosphorylation of Rb at S780 and in E2F‐regulated gene expression. With a remarkable selectivity for CDK4 over 369 human protein kinases, 91 was identified as a highly potent and orally bioavailable drug candidate.Conclusions and ImplicationsWe have identified unique and new inhibitors of CDK4/6 as potential drug candidates. Compound 91 represents an ideal candidate for further development as targeted cancer therapy.
The prevalence of diabetes‐specific emotional distress in people with Type 2 diabetes: a systematic review and meta‐analysis
Authors: Perrin N. E. , Davies M. J. , Robertson N. , Snoek F. J. , Khunti K. 
Published: August 2017

AbstractAimsPsychological comorbidity, such as depression and/or diabetes‐specific emotional distress (diabetes distress), is widespread in people with Type 2 diabetes and is associated with poorer treatment outcomes. Although extensive research into the prevalence of depression has been conducted, the same attention has not been given to diabetes distress. The aim of this systematic review was to determine the overall prevalence of diabetes distress in people with Type 2 diabetes.MethodsSeven databases were searched to identify potentially relevant studies; eligible studies (adult population aged > 18 years with Type 2 diabetes and an outcome measure of diabetes distress) were selected and appraised independently by two reviewers. Multiple fixed‐ and random‐effects meta‐analyses were performed to synthesize the data; with primary analyses to determine the overall prevalence of diabetes distress in people with Type 2 diabetes, and secondary meta‐analyses and meta‐regression to explore the prevalence across different variables.ResultsFifty‐five studies (n = 36 998) were included in the meta‐analysis and demonstrated an overall prevalence of 36% for diabetes distress in people with Type 2 diabetes. Prevalence of diabetes distress was significantly higher in samples with a higher prevalence of comorbid depressive symptoms and a female sample majority.ConclusionsDiabetes distress is a prominent issue in people with Type 2 diabetes that is associated with female gender and comorbid depressive symptoms. It is important to consider the relationship between diabetes distress and depression, and the significant overlap between conditions. Further work is needed to explore psychological comorbidity in Type 2 diabetes to better understand how best to identify and appropriately treat individuals.
Excess psychosocial burden in women with diabetes and premature acute coronary syndrome
Authors: Peters T. M. , Pelletier R. , Behlouli H. , Rossi A. M. , Pilote L. 
Published: August 2017

AbstractAimDiabetes is a stronger risk factor for acute coronary syndrome for women than men. We investigate whether behavioural and psychosocial factors contribute to the disparity in acute coronary syndrome risk and outcomes among women with diabetes relative to women without diabetes and men.MethodsAmong 939 participants in the GENESIS‐PRAXY cohort study of premature acute coronary syndrome (age ≤ 55 years), we compared the prevalence of traditional and non‐traditional factors by sex and Type 2 diabetes status. In a case‐only analysis, we used generalized logit models to investigate the influence of traditional and non‐traditional factors on the interaction of sex and diabetes.ResultsIn 287 women (14.3% with diabetes) and 652 men (10.4% with diabetes), women and men with diabetes showed a heavier burden of traditional cardiac risk factors compared with individuals without diabetes. Women with diabetes were more likely to be the primary earner and have more anxiety relative to women without diabetes, and reported worse perceived health compared with women without diabetes and men with diabetes. The interaction term for sex and diabetes (odds ratio (OR) 1.40, 95% confidence intervals (95% CI) 0.83–2.36) was diminished after additional adjustment for non‐traditional factors (OR 1.12, 95% CI 0.54–2.32), but not traditional factors alone (OR 1.41, 95% CI 0.84–2.36).ConclusionsWe observed trends toward a more adverse psychosocial profile among women with diabetes and incident acute coronary syndrome compared with women without diabetes and men with diabetes, which may explain the increased risk of acute coronary syndrome in women with diabetes and may also contribute to worse outcomes.
Harvest management based on leaf stage of a tetraploid vs. a diploid cultivar of annual ryegrass
Authors: Solomon J. K. Q. , Macoon B. , Lang D. J. 
Published: August 2017

AbstractLeaf stage‐dependent defoliation is linked to the plant's physiological status and may be a more suitable criterion than time‐based intervals for harvesting forage grasses, but no reports of research with annual ryegrass (Lolium multiflorum Lam. var. westerwoldicum) were found. To address this, a 2‐year field study was carried out at Raymond, MS, on a Loring silt loam soil (fine‐silty, mixed, thermic Typic Fragiudalfs). Forage production, morphological characteristics and nutritive value responses to defoliation based on leaf stage (2, 3 and 4 leaves per tiller) and two residual stubble heights (RSH; 5 and 10 cm) of a tetraploid (“Maximus”) vs. a diploid (“Marshall”) cultivar of annual ryegrass were quantified. Forage harvested, in 2011, increased linearly as leaf stage increased from 7.3 to 8.8 Mg/ha, but during 2012 was least (7.0 Mg/ha) at 3‐leaf stage and similar at the other two leaf stages (7.6 Mg/ha). Tiller density was less for Maximus (1,191 tillers/m2) than for Marshall (1,383 tillers/m2). Leaf blade proportion decreased with increasing leaf stage and was greater by 9% for Maximus than for Marshall. Generally, forage nutritive value became less desirable with increasing leaf stage. There was a dichotomy in forage harvested and nutritive value responses, but maximum forage productivity was achieved when annual ryegrass was defoliated at the 4‐leaf stage interval.
Short‐term outcomes of atrial flutter ablation
Authors: Tripathi Byomesh , Arora Shilpkumar , Mishra Abhishek , Kundoor Vishwa Reddy , Lahewala Sopan , Kumar Varun , Shah Mahek , Lakhani Dhairya , Shah Harshil , Patel Nilay V. , Patel Nileshkumar J. , Dave Mihir , Deshmukh Abhishek , Sudhakar Sattur , Gopalan Radha 
Published: August 2017

AbstractBackgroundUnderstanding the factors associated with early readmissions following atrial flutter (AFL) ablation is critical to reduce the cost and improving the quality of life in AFL patients.MethodThe study cohort was derived from the national readmission database 2013–2014. International Classification of Diseases, 9th Revision (ICD‐9‐CM) diagnosis code 427.32 and procedure code 37.34 were used to identify AFL and catheter ablation, respectively. The primary and secondary outcomes were 90‐day readmission and complications including in‐hospital mortality. Cox proportional regression and hierarchical logistic regression were used to generate the predictors of primary and secondary outcomes respectively. Readmission causes were identified by ICD‐9‐CM code in primary diagnosis field of readmissions.ResultReadmission rate of 18.19% (n = 1,010 with 1,396 readmissions) was noted among AFL patients (n = 5552). Common etiologies for readmission were heart failure (12.23%), atrial fibrillation (11.13%), atrial flutter (8.93%), respiratory complications (9.42%), infections (7.4%), bleeding (7.39%, including GI bleed–4.09% and intracranial bleed–0.79%) and stroke/TIA (1.89%). Multivariate predictors of 90‐day readmission (hazard ratio, 95% confidence interval, P value) were preexisting heart failure (1.30, 1.13–1.49, P < 0.001), chronic pulmonary disease (1.37, 1.18–1.58, P < 0.001), anemia (1.23, 1.02–1.49, P = 0.035), malignancy (1.87, 1.40–2.49, P < 0.001), weekend admission compared to weekday admission (1.23, 1.02–1.47, P = 0.029), and length of stay (LOS) ≥5 days (1.39, 1.16–1.65, P < 0.001). Note that 50% of readmissions happened within 30 days of discharge.ConclusionCardiac etiologies remain the most common reason for the readmission after AFL ablation. Identifying high risk patients, careful discharge planning, and close follow‐up postdischarge can potentially reduce readmission rates in AFL ablation patients.
Exercise stress test reveals ineligibility for subcutaneous implantable cardioverter defibrillator in patients with Brugada syndrome
Authors: Tachibana Motomi , Nishii Nobuhiro , Morita Hiroshi , Nakagawa Koji , Watanabe Atsuyuki , Nakamura Kazufumi , Ito Hiroshi 
Published: August 2017

AbstractBackgroundThe eligibility of patients with Brugada syndrome (BrS) for implantation of a subcutaneous implantable cardioverter defibrillator (S‐ICD) is not well known. This study aimed to clarify the eligibility of BrS patients for S‐ICD using electrocardiography (ECG) at rest and during exercise testing. We also analyzed factors associated with ineligibility for S‐ICD from standard 12‐lead ECG at rest.MethodsWe enrolled 110 consecutive BrS patients who visited Okayama university hospital from December 2015 to December 2016. All patients were assessed for S‐ICD eligibility, which required one lead to satisfy the S‐ICD screening template. We assessed standard 12‐lead ECG parameters in all participants. Of those who passed S‐ICD screening, 45 patients were assessed for S‐ICD eligibility during treadmill stress test.ResultsMean age of study patients was 54 ± 13 years and 108 (98%) were men. In total, 89 patients (81%) satisfied S‐ICD indications at rest. Existence of complete right bundle branch block (CRBBB) on standard 12‐lead ECG was a significant predictor of ineligibility for S‐ICD (odds ratio, 5.00; P = 0.03; 95%CI, 1.14–21.98). Of the 45 patients who underwent treadmill stress testing, 11 patients (24%) showed ineligibility for S‐ICD during the test.ConclusionCRBBB was a predictor of ineligibility for S‐ICD in patients with BrS. Sinus tachycardia changes ECG morphology in some patients and stress testing should be considered before S‐ICD implantation.