bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical study of Gene‐Eden‐VIR/Novirin in genital herpes: suppressive treatment safely decreases the duration of outbreaks in both severe and mild cases
Authors: Polansky Hanan , Itzkovitz Edan , Javaherian Adrian 
Published: October 2016

AbstractBackgroundWe conducted a clinical study that tested the effect of suppressive treatment with the botanical product Gene‐Eden‐VIR/Novirin on genital herpes. Our previous paper showed that the treatment decreased the number of genital herpes outbreaks without any side effects. It also showed that the clinical effects of Gene‐Eden‐VIR/Novirin are mostly better than those reported in the studies that tested acyclovir, valacyclovir, and famciclovir. The current paper reports the effect of suppressive treatment with Gene‐Eden‐VIR/Novirin on the duration of outbreaks, in severe and mild genital herpes cases.MethodsThe framework was a retrospective chart review. The population included 137 participants. The treatment was 1–4 capsules per day. The duration of treatment was 2–48 months. The study included three controls: baseline, no‐treatment, and dose–response.ResultsThe treatment decreased the duration of outbreaks in 87 % of participants and decreased the mean duration of outbreaks from 8.77 days and 6.7 days in the control groups to 2.87 days in the treatment group (P < 0.001, both groups). All participants reported no adverse experiences.ConclusionsThis paper shows that suppressive treatment with Gene‐Eden‐VIR/Novirin decreased the duration of genital herpes outbreaks, in both severe and mild cases, without any side effects. Based on the results reported in this and our previous paper, we recommend suppressive treatment with Gene‐Eden‐VIR/Novirin as a natural alternative to both suppressive and episodic treatments with current drugs, in both severe and mild genital herpes cases.Trial registration ClinicalTrials.gov NCT02715752 Registered 17 March 2016 Retrospectively Registered
MG-63 cells proliferation following various types of mechanical stimulation on cells by auxetic hybrid scaffolds
Authors: Choi Hong Jin , Lee Jun Jae , Lee Jung Bok , Sung Hak-Joon , Shin Jung-Woog , Shin Ji Won , Wu Yanru , Kim Jeong Koo 
Published: October 2016

Abstract

Background
Mechanical properties and cyto-compatibility of a composite scaffold which possessed negative (−) Poisson’s ratio (NPR) was investigated for effective load transfer from auxetic scaffold to cell.

Methods
Organic/inorganic composite scaffolds were prepared by mixing hydroxyapatite (HA) to poly(lactide-co-glycolide) (PLGA). To induce NPR in composite scaffold, 3-directional volumetric compression was applied during the scaffold fabrication at adequate temperature(60°C). The pore size of scaffold ranged between 355–400 μm.

Results
Poisson’s ratios of NPR scaffolds and control scaffolds were −0.07 and 0.16 at 10 % strain. For stable physical stimulating to loaded cells, ceramic/polymer composite scaffold was prepared by incorporating HA in PLGA to increase mechanical strength. Compressive strength of the HA/PLGA composite scaffold (15 wt. % HA to PLGA) was about 21.7 % higher than that of PLGA-only scaffold. The recovery rates of the NPR composite scaffold after applying compression in the dry and wet states were 90 % and 60 %, respectively. Also the composite scaffold was shown to have better hydrophilicity (61.9°) compared to the PLGA-only scaffolds (65.3°). Cell proliferation of osteoblast-like cell line (MG-63) in the composite scaffold was 20 % higher than in PLGA-only scaffold at static compressive stimulation. For dynamic compressive stimulation (15 min cyclic interval), cell proliferation in the composite scaffold was 2 times higher than that of in PLGA-only scaffold. In conclusion, NPR composite (HA/PLGA) scaffold was effective in isotropic compressive load delivery for osteogenic cell proliferation.

Conclusion
This composite scaffold with stimulation can be used as tissue engineered scaffold and dynamic cell culture system for bone tissue regeneration.
Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures
Authors: Potter Gregory D. M. , Skene Debra J. , Arendt Josephine , Cade Janet E. , Grant Peter J. , Hardie Laura J. 
Published: October 2016

AbstractCircadian (∼24-hour) timing systems pervade all kingdoms of life and temporally optimize behavior and physiology in humans. Relatively recent changes to our environments, such as the introduction of artificial lighting, can disorganize the circadian system, from the level of the molecular clocks that regulate the timing of cellular activities to the level of synchronization between our daily cycles of behavior and the solar day. Sleep/wake cycles are intertwined with the circadian system, and global trends indicate that these, too, are increasingly subject to disruption. A large proportion of the world's population is at increased risk of environmentally driven circadian rhythm and sleep disruption, and a minority of individuals are also genetically predisposed to circadian misalignment and sleep disorders. The consequences of disruption to the circadian system and sleep are profound and include myriad metabolic ramifications, some of which may be compounded by adverse effects on dietary choices. If not addressed, the deleterious effects of such disruption will continue to cause widespread health problems; therefore, implementation of the numerous behavioral and pharmaceutical interventions that can help restore circadian system alignment and enhance sleep will be important.
Phosphorylation of STAT2 on serine-734 negatively regulates the IFN-α-induced antiviral response
Authors: Steen Håkan C. , Kotredes Kevin P. , Nogusa Shoko , Harris Michele Y. , Balachandran Siddharth , Gamero Ana M. 
Published: October 2016

ABSTRACT
Serine phosphorylation of STAT proteins is an important post-translational modification event that, in addition to tyrosine phosphorylation, is required for strong transcriptional activity. However, we recently showed that phosphorylation of STAT2 on S287 induced by type I interferons (IFN-α and IFN-β), evoked the opposite effect. S287-STAT2 phosphorylation inhibited the biological effects of IFN-α. We now report the identification and characterization of S734 on the C-terminal transactivation domain of STAT2 as a new phosphorylation site that can be induced by type I IFNs. IFN-α-induced S734-STAT2 phosphorylation displayed different kinetics to that of tyrosine phosphorylation. S734-STAT2 phosphorylation was dependent on STAT2 tyrosine phosphorylation and JAK1 kinase activity. Mutation of S734-STAT2 to alanine (S734A) enhanced IFN-α-driven antiviral responses compared to those driven by wild-type STAT2. Furthermore, DNA microarray analysis demonstrated that a small subset of type I IFN stimulated genes (ISGs) was induced more by IFNα in cells expressing S734A-STAT2 when compared to wild-type STAT2. Taken together, these studies identify phosphorylation of S734-STAT2 as a new regulatory mechanism that negatively controls the type I IFN-antiviral response by limiting the expression of a select subset of antiviral ISGs.
Previous vena cava occlusion as the cause of a bilateral iliofemoral thrombosis
Authors: Burkert B. , Regeniter Ph. , Mumme A. , Hummel T. , Mühlberger D. 
Published: October 2016

SummaryA case of bilateral iliofemoral thrombosis in a 17-year-old [male] patient is presented. It was only revealed during bilateral transfemoral thrombectomy that the thrombosis was due to previous inferior vena cava occlusion. This required a complex interventional reconstruction of the vena cava with secondary stenting of both renal veins. The postoperative venogram showed blood outflow from the left renal vein into the portal vein and from the right renal vein into the inferior vena cava via collaterals. At follow-up presentation, the patient was asymptomatic with normal findings on computed tomography scanning.
Pyoderma gangraenosum – from the right diagnostic investigations to targeted therapy
Authors: Jockenhöfer F. , Dissemond J. 
Published: October 2016

SummaryPyoderma gangrenosum (PG) is a rarely diagnosed neutrophilic skin disorder that still remains a diagnosis of exclusion. Therefore, the diagnosis has to be done in the synopsis of typical clinical findings, patient’s history and exclusion of relevant differential diagnoses. There are numerous references to relevant comorbidities from the metabolic syndrome, rheumatoid arthritis and inflammatory bowel diseases. Of particular importance is the potential association of PG with (haematologic) neoplasms. Treatment of PG includes topical and systemic immuno-modulating or immuno-suppressant therapies. Most important are for topical as well as systemic treatments are glucocorticoids. All other treatments represent an off-label-use. Especially Cyclosporine and TNF-α-inhibitors demonstrated very good and promising clinical results. Accompanying modern moist wound-therapy concepts avoiding painful dressings and an analgesic therapy are recommended.
Interstate Standard on Measurement Assurance of Occupational Safety (GOST 12.0.005-2014)
Authors: Черный  , Chernyy K. 
Published: October 2016

An experience related to fixing of uniform requirements to metrological support in the labor safety area in Eurasian
countries using interstate standardization procedures is considered. The approaches to ensuring the unity of measurements
realized in the interstate standard during a control process for parameters determining a labor conditions status from a
labor safety position are discussed.
Internationalizing the art school: What part does the studio have to play?
Authors: Caldwell Elizabeth , Gregory Jodi 
Published: October 2016

Abstract
Art, Design and Architecture (ADA) education has a number of distinctive features, including the use of the studio as a locus for an interactive approach to teaching and learning. This article explores the concept of ‘internationalization’ and uses it as a basis to explore the pedagogies found in ADA from an intercultural perspective. The study involved staff and international students participating in focus groups and workshop events to share their experiences of teaching and learning in ADA. We found that ADA pedagogies provide a number of specific opportunities and challenges for internationalization. Positive aspects include the social nature of the studio facilitating the development of independent learning and critical skills. However, the issues raised were the lack of value placed on the development of IT/technical skills and language proficiency. We suggest that there is much that ADA pedagogies have to offer on the debate on internationalization.
Modern Trends in Airport Self Check-in Kiosks
Authors: Sabatová Jarmila , Galanda Jozef , Adamčík František , Jezný Martin , Šulej Radoslav 
Published: October 2016

<p align="LEFT">Due to maintain the flow of the check-in process of air passengers, it is essential that services that ensure this process have been carried as quickly and effectively. One of the major current problems in this area is the efficiency of clearance of a large number of passengers over the check-in counters. By the gradual development of so-called self check-in services eventually delegate some activities in check-in process to passengers and the entire clearance process to speed up. In this article the authors deal with current state of the use of self check-in services in the world and predict the expected evolution of these services in the future. Subsequently, the authors present a new design of self-service kiosk and graphical user interface (GUI) of application such self-service check-in kiosk based on the analysis of the functions and features of similar solutions available on the market and with considering all currently known IATA requirements and the criteria relating to disabled passengers in order to lighten the load check-in counters and thereby accelerated the clearance of the passenger at the airport. The aim of the authors was to create a cost competitive solution offering such new features and services that do not offer other solutions, with an emphasis on improving the efficiency of the check-in process of passengers at the airport.</p>
Image Analysis in Wood Testing - Selected Examples
Authors: Wąsik Radosław , Michalec Krzysztof 
Published: October 2016

Abstract
This paper is a review article which presents examples of application of the image analysis in wood testing. The objective of the paper was to present selected research methods with the use of image analysis used in the research on anatomy and macro-structure of wood carried out in the Department of Forest and Wood Utilization of the Institute of Forest Utilization and Forest Technology of the University of Agriculture in Krakow. In the part concerning research on wood anatomy the following areas of application of the image analysis were indicated: identification of wood species and variability of the selected parameters of the anatomic structure with special attention to coniferous trees. In the part concerning the research on macro-structure of wood, methodology of collection and preparation of wood samples and measurement of the most important properties of the macrostructure was described with the use of the image analysis program. Moreover, the selected areas of practical application of the results of such analysis were indicated.
Integration Trends of EU Internal Security and Law Enforcement: How Legal, Technological and Operational Advancements Matter
Authors: Loik Ramon 
Published: October 2016

AbstractRising concerns about the spread of cross-border criminal networks and transnational terrorism have transformed the international security arena into a more diverse, fragmented, diffused, less visible and hardly predictable one. Thus, (in)security is more mobile and remote than some decades ago. The establishment of an integrated European security area requires efforts to develop common standards and joint practices in terms of harmonisation of legal systems, advanced integration of security measures and tools, coherence of procedures and shared operational methods of law enforcement. The article discusses the main integration trends, challenges and options of internal security reforms in the European Union (EU) from legal, technological and operational advancement perspectives. It is argued that some harmonisation of criminal law as sharing and pooling of sovereignty has been achieved on the supranational level. The approach of supra-territoriality development is proposed in terms of shared security space management, where enhanced functional needs towards discursive coherence by copulative regulations and technological measures can be innovated to overcome some obstacles in the EU’s security integration and achieve further operational success.
The Concepts of Trademark Exhaustion and Parallel Imports: A Comparative Analysis between the EU and the USA
Authors: Dobrin Samuel , Chochia Archil 
Published: October 2016

AbstractThe article intends to analyze the closely correlated concepts of trademark exhaustion and parallel imports. The growing importance of these concepts in the current world, especially in the European Union, makes it an interesting research topic, even though the concepts are complicated due to their nature and different actors involved. The authors use comparative approach, concentrating on two world leaders in the field, in order to discover what is the approach of the EU as well as the approach of the USA to the concepts of trademark exhaustion and parallel imports, what are the benefits and weaknesses of these approaches, and analyze why these markets have arrived at certain conclusions.
Cultural Diplomacy of Slavic European Union Member States: A Cross-country Analysis
Authors: Udovič Boštjan , Podgornik Ana 
Published: October 2016

Abstract
The article deals with the role of cultural diplomacy in Slavic EU Member States. Its basic idea is to present the main characteristics of cultural diplomacy as a field of possible cooperation between the Slavic EU member countries. The conclusions of the research are three: firstly, the cultural diplomacy of the Slavic EU Member States is fragmented and diversified. Secondly, each country promotes its own cultural diplomacy and there is almost no cooperation between countries in the cultural field. Finally, cultural diplomacy is still an omitted instrument of Slavic EU Member States and a fertile ground for future collaboration within the EU and in the region of Central Europe.
PID Controller Design Based on Radial Basis Function Neural Networks for the Steam Generator Level Control
Authors: Xiangsong Kong , Xurui Chen , Jiansheng Guan 
Published: October 2016

Abstract
Steam generator level control system is a vital control system for the Pressurized Water Reactor (PWR). However, the steam generator level process is a highly nonlinear and non-minimum phase system, the conventional Proportional- Integral-Derivative (PID) control scheme with fixed parameters was difficult to obtain satisfactory control performance. The Radial Basis Function (RBF) Neural Networks based PID control strategy (RBFNN-PID) is proposed for the steam generator level control. This method can identify the mathematical model of the steam generator via the RBF neural networks, and then the PID parameters can be optimized automatically to accommodate the characteristic variation of the process. The optimal number of the hidden layer neurons is also discussed in this paper. The simulation results shows that the PID controller designed based on the RBF neural networks has good control performance on the steam generator level control.
Capacity of Right-Turn Lane at Signalized Intersection under Pedestrian-Bicycle Effect
Authors: Gao Chao , Liu Xiao-Ming , Yang Xiao-Kuan 
Published: October 2016

Abstract
The effect of pedestrian and bicycle infrastructure is used to analyze the capacity for right-turn lane at signalized intersection. Each cycle at the signalized intersection was divided into several periods. The effect of pedestrian and bicycle at each period was analyzed. The number of right-turn cars going through signalized intersection was calculated by using probability theory and mathematical statistics. The capacity under the effect of pedestrian and bicycle for right-turn lane at signalized Intersection was deduced. The calculated results were deduced by using the survey data of two signalized intersections at Jinan city. The mean difference values are 8% and 10.1%, compared with VISSIM simulation results. The comparisons show that this model can fully describe the effect of pedestrian and bicycle to signalized intersection.
The use of situation-bound utterances in Chinese foreign language textbooks
Authors: Yeh Shu-Han 
Published: October 2016

AbstractThis article examines the use of situation-bound utterances (qíngjìng zhuānyòngyǔ情境专用语) in five mainstream Chinese foreign language textbooks in order to survey, categorize, and discuss their use therein. Kecskes (2000a. A cognitive-pragmatic approach to situation-bound utterances.Journal of Pragmatics32(5). 605–625) defined Situation-bound utterances (hereafter SBUs) as “highly conventionalized, prefabricated pragmatic units whose occurrences are tied to standardized communicative situations” (2000a: 606). SBUs are prevalent in Modern Chinese and in several ways represent Chinese culture. Many Chinese foreign language textbooks, however, underestimate the importance of SBUs. Based on information culled from five textbooks (Integrated Chinese中文听说读写,First Step中文起步,Basic Spoken Chinese基础中文：听与说,Practical Audio-Visual Chinese实用视听华语, andNew Practical Chinese Reader新实用汉语) a Chinese SBUs database has been generated. One hundred seventy-eight Chinese SBUs are identified, and they are categorized into ten speech act categories. Among these, the three most common speech acts are: (1) greetings/daily conversation, (2) polite request, and (3) inquiry. These speech acts represent and reflect the concept and practice of politeness in Chinese culture.Basic Spoken Chineseprovides the most detailed and clearest explanations of SBUs, and explains the most appropriate contexts for use of SBUs. As for repeated use of SBUs, bothBasic Spoken ChineseandIntegrated Chineseoutperformed the other textbooks. None of the textbooks examined, however, adequately explain the use and importance of SBUs in Modern Chinese. The purpose of this study is to fill this lacuna.
人类空间、时间感知对人类语言结构的普遍影响：语义距离象似性跟可别度领先象似性及其引申
Authors: 丙甫 陆 
Published: October 2016

提要汉语语法的特点是形态少，语法编码主要依靠语序和虚词。本文在强调语序之重要性的基础上，指出决定语序的两个最基本的动因：空间性的 “语义距离象似性” 和时间性、语用性的 “可别度领先象似性”，并对这两个动因的种种引申用法做了初步梳理。这两个动因的广泛存在表明，人类最基本的两个感知范畴，空间感知和时间感知，在语言机制中也发挥了决定性作用。
汉越词对越南学生汉语阅读的影响
Authors: 金英 武 
Published: October 2016

提要本文的目的是为了使学生能够更快更好地提高阅读理解的能力，能够利用好汉越词来理解汉语词语。论文考察了汉越词对越南学生在阅读汉语对越南学生的帮助和常常由此引起的偏误，并得出了影响的原因，进而针对这些问题提出了一些教学对策。论文界定了有关汉越词的一些概念，进而在《成语辨析词典》、《汉语俗语词典》、《汉语歇后语辞典》中，随机抽样成语、俗语、歇后语作为引例进行分析。同时，也从《汉语水平词汇与汉字等级大纲》里随机抽样词语来当例句而进行研究和分析汉语词语与汉越词在语义、篇章方面的对应关系。然后，考察了越南学生在阅读汉语过程中，汉越词对汉语词语理解的帮助以及存在的偏误。论文对那些帮助和偏误产生的原因进行了具体分析，并针对这些原因提出具体的教学对策。本文还对利用汉越词在阅读汉语教学以及教材编写方面提出一些建议。希望通过本文的研究和分析可以提高对越南学生的汉语阅读教学效果，提高越南学生学习阅读的效率。本文的研究结论在汉语阅读教学工作中，无论是在课堂教学还是教材编写方面，都会有一定的参考价值。
Evaluation of Biogas Production and Usage Potential
Authors: Kalinichenko Antonina , Havrysh Valerii , Perebyynis Vasyl 
Published: October 2016

Abstract
The aim of the research is the development of theoretical and methodical bases for determining the feasibility of plant raw materials growing for its further bioconversion into energy resources and technological materials to maximize profit from business activities. Monograph, statistics, modelling and abstract logical methods have been used during the research. Directions of biogas usage have been examined. Biogas yields from different crops have been analyzed. It has been determined that high methane yields can be provided from root crops, grain crops, and several green forage plants. So, forage beet and maize can provide more than 5,500 m3 of biogas per hectare. Attention is paid to the use of by-products of biogas plants, especially carbon dioxide. Carbon dioxide is an important commodity and can increase profitability of biogas plant operating. It can be used for different purposes (food industry, chemical industry, medicine, fumigation, etc). The most important parameters of the biogas upgrading technologies have been analyzed. If output of an upgrade module is more than 500 nm3/h, investment costs of different available technologies are almost equal. According to experts, it is economically feasible to use anaerobic digestion biogas systems to upgrade biomethane provided their performance is equivalent to 3,000 litres of diesel fuel per day. The economic and mathematical models have been suggested to determine the feasibility of growing plant materials to maximize the gross profit. The target function is the maximum gross income from biogas utilization. It has the following limitations: annual production of biogas, consumption of electricity, heat and motor fuels. The mathematical model takes into account both meeting own requirement and selling surplus energy resources and co-products including carbon dioxide. In case of diesel fuel substitution, an ignition dose of diesel fuels has been considered. The algorithm for making a decision on construction of a biogas plant has been offered.