bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short Tandem Repeat stutter_model_inferred from direct measurement of in vitro stutter noise
Authors: Raz Ofir , Biezuner Tamir , Spiro Adam , Amir Shiran , Milo Lilach , Titelman Alon , Onn Amos , Chapal-Ilani Noa , Tao Liming , Marx Tzipy , Feige Uriel , Shapiro Ehud 
Published: July 2016

AbstractShort tandem repeats (STRs) are polymorphic genomic loci valuable for various applications such as research, diagnostics and forensics. However, their polymorphic nature also introduces noise duringin vitroamplification, making them difficult to analyze. Although it is possible to overcome stutter noise by using amplification-free library preparation, such protocols are presently incompatible with single cell analysis and with targeted-enrichment protocols. To address this challenge, we have designed a method for direct measurement ofin vitronoise. Using a synthetic STR sequencing library, we have calibrated a Markov model for the prediction of stutter patterns at any amplification cycle. By employing this model, we have managed to genotype accurately cases of severe amplification bias, and biallelic STR signals, and validated our model for several high-fidelity PCR enzymes. Finally, we compared this model in the context of a naïve STR genotyping strategy against the state-of-the-art on a benchmark of single cells, demonstrating superior accuracy.
The assessment of ICT literacy of Iranian teachers through the ISST model
Authors: Pourkarimi Javad , Nazarzadeh Zare Mohsen 
Published: July 2016

Purpose
– The purpose of this paper is to examine the views of experts of educational technology and teachers in Tehran, about the components of ICT literacy based on the ISST model.

Design/methodology/approach
– This study conducted a descriptive methodology by using a survey method. The statistical population consisted of 9,800 teachers and 37 experts of educational technology in Tehran; owing to the small size of the experts’ population, all 37 experts were selected for research, and a sample of 266 teachers was selected based on the cluster sampling method. To collect the necessary data, the researcher designed a questionnaire based on four key components of the ISST model. To analyze the data, statistical procedures including the Kolmogrov-Smirnov test, one sample t-test and independent t-test were used.

Findings
– The findings of research showed that from the viewpoint of experts all components of ICT literacy were significant. On the other hand, from the viewpoint of teachers, all components of ICT literacy except the component of information society were significant. Furthermore, the findings showed that, there were a significant difference (p=0.05) between the views of experts and teachers about all components of ICT literacy, except the component of information processing.

Practical implications
– The study showed that to equip all teachers with the components of ICT literacy such as information device, information society, information processing and information handling can help them to improve efficiency and effectiveness, and also the ISST model applied in this study can be used by other functional areas.

Originality/value
– This study showed that fundamental training in the field of ICT literacy for teachers is very essential in the education system, because fluency of ICT skills can help them to increase better performance, and subsequently to increase self-value, motivation, feeling of success and productivity in the work environment.
Measuring fatigue-related impairment in the workplace
Authors: Powell Ronald I. , Copping Alex G. 
Published: July 2016

PurposeThis research was founded on the premise that more can be done to help improve safety in the global construction industry. Worker fatigue-impairment may be an underlying cause or major contributor to accidents. Fatigue-impairment is believed to be pervasive in construction, and research has shown it can be as concerning as alcohol-impairment. When fatigue-impairment is acknowledged as existing, there is poor understanding of its severity or how it contributes to performance and accidents. The purpose of this research was to attempt to measure fatigue-impairment in real time.Design/methodology/approachThis research expanded on actual measurements of fatigue-related impairment from workers on a large construction project displaying significant fatigue-related impairment. The research identified and tested possible techniques for real-time measurement solutions to assist with this safety-related issue. 100 participants had their sleep/wake cycles monitored for a month with an actigraph to derive their on-going mental effectiveness levels by the minute. The same participants took cognitive tests over the month to compare mental performance results to the modelled mental effectiveness levels.FindingsPerformance results from cognitive tests were compared with modelled mental effectiveness from actigraph-monitored sleep of 100 participants for a month each and showed significant correlation for all cognitive tests used.Practical implicationsThis research showed that real-time surrogate measurements for fatigue-impairment in the workplace exist to assist organizations manage an important workplace hazard.Originality/valueDerived from operational settings, this research developed predictive models based on simple, quick and inexpensive cognitive tests as screening techniques for workplace impairment and confirmed the need for and found a solution for fatigue monitoring in the workplace.
Comparison of sustainability characteristics of conventional and CNC turning processes
Authors: Jayakrishna K. , Girubha R. Jeya , Vinodh S. 
Published: July 2016

Purpose
The purpose of this paper is to present the comparison of sustainability characteristics of conventional and computer numerical control (CNC) turning process. The sustainability performance measures of both the processes were also being evaluated.

Design/methodology/approach
The study discusses the achievement of sustainability characteristics at the manufacturing process level of widely used industrial process, mechanical machining. Sustainable development includes improvements in material, product design and manufacturing process orientations. The present study narrates the sustainability characteristics at the process level.

Findings
The results confirm that the overall sustainability characteristics of CNC machining are potentially high considering the economic and environmental aspects of the machining parameters. A detailed life cycle analysis for both conventional and CNC turning was performed to evaluate the environmental impact and benefits.

Research limitations/implications
The study contributed in the paper is limited to process dimension of sustainability. The economic and environmental aspects of machining were also being discussed.

Practical implications
The conduct of the study enabled the comparison of sustainability characteristics of conventional and CNC-turning processes. The approach could also be expanded for the comparison of sustainability characteristics of other manufacturing processes also.

Originality/value
The study is an attempt to explore the process sustainability by the comparison of environmental impact of making processes. Hence, the contributions are original.
Measuring Qatar’s compliance with international standards on money laundering and countering the financing of terrorism
Authors: Truby Jon 
Published: July 2016

Purpose
Under scrutiny in light of the growing threat of international terrorism, Qatar faces pressure and accusations that it is not doing enough to counter terror financing and clamp down money laundering. The issue is not that Qatar is avoiding positive action, but that by the time measures are implemented, they become outdated because the international community has by then tightened its regulatory requirements. Qatar’s slow pace has led to a case of cat-and-mouse chase with respect to updating its standards, with a revised set of rules being required by the time Qatar implements the last set of international standards. This study aims to draw on lessons from the past to help Qatar avoid findings of it falling below international standards in the upcoming 2017 mutual evaluation.

Design/methodology/approach
The primary purpose of this article is to catalogue Qatar’s efforts to comply with international anti-money laundering (AML) and anti-terror finance standards. It demonstrates the real legislative progress post-2008 recorded by Qatar to minimize money laundering and terrorist financing. The paper also contests the view that Qatari law is insufficient.

Findings
The paper explains Qatar’s efforts to comply with the recommendations made by each evaluation by the Financial Action Task Force (FATF). It also highlights the potential for Qatar to be caught out again by the evolution of international expectations in an upcoming review, which, it is understood, is likely to take place in 2017.

Originality/value
No article exists specifically on this research field. As Qatar prepares for its 2017 FATF evaluation, it should be reminded of the need to comply with all new standards.
A conceptual approach to the relationships between the social economy, social welfare, and social innovation
Authors: Shin Changhwan 
Published: July 2016

Purpose
With the aim of finding a balance between social and economic benefits, the social economy has reemerged in the crisis of the welfare state. The Fordist welfare state can be characterized by state-provided welfare, the mediation of paid work and welfare by the labor market and redistributive policies. Globally, neoliberalism and the market have given rise to social exclusion; in this context, the social economy is emerging as an alternative to the market domination of societies. This paper aims to construct a conceptual framework of welfare provision in an open innovation era.

Design/methodology/approach
The welfare state system between the Fordist welfare state and post-Fordist welfare state is different on provision and delivery of welfare service. To construct the conceptual relation among the social economy, the state and the market and welfare provision in the social economy, this study mainly used the literature review.

Findings
Attention should be paid to civil society at the local level to ignite social economy through open social innovation. Various social actors in the local community need to change and develop the social economy with collaborative entrepreneurship and collaborative economic mindsets.

Research limitation/implications
This paper presents the welfare service model led by social economy and open innovation, as well as social change. To fill the shortage of welfare provision caused by crisis of the welfare state, social economy is considered as an alternative for neo-liberalism. This study emphasizes that endogenous local development is a prerequisite for social economy as a welfare supplier.

Practical implications
In the social economy, reciprocity, democracy, self-help and social capital at the local level are emphasized. Also, open innovation put emphasis on collaboration economy among the local community, firms and the public sector: this emphasis can be expected to affect the welfare provision system and the social relations surrounding welfare. To address social problem and social needs, the social economy can adapt and apply the open innovation model.

Originality/value
The previous researches on open innovation mainly deal with the business sector and the public sector, but this paper has a focus on the relation between provision of social welfare and social innovation. The social economy is likely to function properly on the foundation of open social innovation.
The philosophy of “open innovation”
Authors: Yun JinHyo Joseph , Park KyungBae , Yang JeongHo , Jung WooYoung 
Published: July 2016

Purpose
The purpose of this paper is to explore the ideological foundation of open innovation strategies and the open business model, which are appearing as new industrial paradigms based on information technology (IT).

Design/methodology/approach
First, this paper examined the ideological foundation of Deleuze, Whitehead, and Popper. Next, Taoism was scrutinized to discover concrete bases for open innovation.

Findings
Here, it was found that Taoism completely coincides with the logical basis of open innovation. The theory “the supreme good is like water” of Taoism means to vacate oneself and fill the space with others to create paradoxes, thereby filling oneself with a more creative method.

Originality/value
Taoism provides a way to present paradoxes through the idea of vacating and opening to reach a creative stage of leaving nature as it is.
On the Relation between Local Amenities and House Price Dynamics
Authors: Beracha Eli , Gilbert Ben T , Kjorstad Tyler , Womack Kiplan 
Published: July 2016

AbstractThis study explores the extent to which local amenities are related to house price volatility, returns and risk‐adjusted returns across 238 MSAs. We find strong evidence that high amenity areas experience greater price volatility. In regards to returns, high amenity areas experience greater (lower) real returns in appreciating (depreciating) markets. However, high amenity areas experience little to no abnormal risk‐adjusted returns. Results from the study are robust to an endogenous treatment of amenities and land supply elasticity. Overall, we conclude that the desirability of a metropolitan area is a significant channel through which land values drive house price dynamics.
Bondi's Big Rock: explanations and representations in coastal geomorphology
Authors: Booth Douglas 
Published: July 2016

AbstractSitting on the shore platform at Ben Buckler, the north‐east headland of Bondi Beach, Sydney, is a large isolated boulder, weighing around 235 tons. In this article I analyse geomorphological explanations for, and historical representations of, the boulder, locally known as the Big Rock. Explanations for and representations of Bondi's Big Rock typically appear in discussions and debates about changes to the New South Wales coast and the impact of storm waves and tsunami. Geomorphologists date the Big Rock from a storm in July 1912 and have identified a range of wave sizes and forms to explain its presence. Yet, neither their explanations nor evidence have convinced a number of local residents who claim the rock existed before the 1912 storm. Bondi's Big Rock is thus a valuable reminder that geomorphological features are not fully formed subjects. Rather, they must be defined and contextualised in inordinately complex processes of explanation and representation that ultimately are always interpretations.
Ground beetles (Coleoptera: Carabidae) inhabiting anthropogenic habitats in the lower delta of the Paraná river, Argentina: geographic distribution and ecological characteristics
Authors: Nanni Analia S , Quintana Rubén D , Fracassi Natalia G , Cicchino Armando C 
Published: July 2016

AbstractThe primary aims of this paper were to provide the first inventory of carabid beetles collected in five different anthropogenic habitat types of the Lower Delta of the Paraná River, to describe their main ecological characteristics and to provide information on their distribution range in ecoregions, subregions and ecosystem complexes of Argentina and across the Neotropical region. Species were grouped according to six classes of distributions in relation to their presence in the Delta of the Paraná River. In addition, rarefaction curves were built in order to compare the seasonal species richness. We collected 1486 individuals belonging to 48 species. The southernmost distribution limit of 50% of the species is located south of the Delta region. Moreover, 21% of the species are confined to the Delta and Islands of the Parana and Uruguay Rivers ecoregion and to localities within the neighbouring ecoregions of Espinal and Pampa. Most (63%) of the species were zoophagous and 25% were either omnivorous or seed eaters; 52% were hydrophilous, 44% mesophilous and one was xerophilous. The high number of species found in this ecoregion emphasising its importance as a biodiversity hotspot of South American carabids. Human activities have led to changes in the landscape of the Delta Islands which could favour the establishment of mesophilous and xerophilous species from other ecoregions. Seasonal carabid richness is higher in the warm seasons (spring and summer) compared with the cold seasons (autumn and winter). Although, the highest absolute richness was found in the most anthropised habitat types, secondary forests had exclusive species, showing the importance of preserving the ecological mosaic of the landscape.
Evidence that independent gut‐to‐brain and brain‐to‐gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1‐year population‐based prospective study
Authors: Koloski N. A. , Jones M. , Talley N. J. 
Published: July 2016

SummaryBackgroundTraditionally, functional gastrointestinal disorders (FGIDs) are conceptualised as originating in the brain via stress pathways (brain‐to‐gut). It is uncertain how many with irritable bowel syndrome (IBS) and functional dyspepsia (FD) have a gut origin of symptoms (gut‐to‐brain pathway).AimsTo determine if there is a distinct brain‐to‐gut FGID (where psychological symptoms begin first) and separately a distinct gut‐to‐brain FGID (where gut symptoms start first).MethodsA prospective random population sample from Newcastle, Australia who responded to a validated survey in 2012 and completed a 1‐year follow‐up survey (n = 1900). The surveys contained questions on Rome III IBS and FD and the Hospital Anxiety and Depression Scale.ResultsWe found that higher levels of anxiety and depression at baseline were significant predictors of developing IBS (OR = 1.31; 95% CI 1.06–1.61, P = 0.01; OR = 1.54; 95% CI 1.29–1.83, P < 0.001) and FD (OR = 1.28; 95% CI 1.05–1.55, P = 0.01; OR = 1.55, 95% CI 1.32–1.83, P < 0.001), respectively, at the 1‐year follow‐up. Among those people who did not have elevated levels of anxiety and depression at baseline, subjects at baseline with documented IBS (mean difference 0.34; 95% CI 0.13–0.55, P = 0.002; 0.81; 95% CI 0.47–1.15, P < 0.001) and FD (0.38; 95% CI 0.14–0.63, P = 0.002; 0.92; 95% CI 0.57–1.27, P < 0.001), reported significantly higher levels of anxiety and depression at the 1‐year follow‐up. We calculated in one‐third of individuals a mood disorder precedes FGID but in two‐thirds an FGID precedes the mood disorder.ConclusionWhile brain–gut pathways are bidirectional, a major subset begin with gut symptoms first and only then psychological distress develops, implicating primary gut mechanisms as drivers of the gut and extra‐intestinal features in many cases.
Prognostic significance of baseline peripheral absolute neutrophil, monocyte and serum β2‐microglobulin level in patients with diffuse large b‐cell lymphoma: a new prognostic model
Authors: Chen Yiming , Neelapu Sattva , Feng Lei , Bi Weiqi , Yang Tian‐Hui , Wang Michael , Fanale Michelle A. , Westin Jason R. , Hagemeister Fredrick B. , Fayad Luis E. , Romaguera Jorge E. , Samaniego Felipe , Turturro Francesco , Fowler Nathan H. , McLaughlin Peter , Cabanillas Fernando , Oki Yasuhiro , Nastoupil Loretta J. , Rodriguez Alma 
Published: July 2016

SummaryThere are limited reports that baseline peripheral absolute neutrophil count (ANC), absolute monocyte count (AMC), absolute lymphocyte count (ALC) and serum β2‐microglobulin level independently predict survival in patients with diffuse large B‐cell lymphoma (DLBCL). To confirm these findings, we analysed these parameters together with components of the International Prognostic Index (IPI) in patients with newly‐diagnosed DLBCL. We evaluated baseline clinical features for their ability to predict survival in 817 newly diagnosed, previously untreated patients with DLBCL who received frontline treatments between October 2001 and December 2011. The median age at diagnosis was 58 years. Multivariate analysis identified elevated baseline ANC (P = 0·036), AMC (P = 0·028) and serum β2‐microglobulin level (P < 0·001), poor performance status (P < 0·001) and high number of extranodal disease sites (P = 0·0497) as independent unfavourable predictors of OS; serum β2‐microglobulin level was the strongest predictor of survival outcomes among all the parameters. High baseline serum β2‐microglobulin, ANC and AMC levels are independent prognostic factors for short overall survival in patients with newly diagnosed DLBCL. Our new model, based on the above five parameters, better stratifies patients into various risk categories than the IPI for newly diagnosed DLBCL.
Mycophenolate mofetil for the treatment of children with immune thrombocytopenia and Evans syndrome. A retrospective data review from the Italian association of paediatric haematology/oncology
Authors: Miano Maurizio , Ramenghi Ugo , Russo Giovanna , Rubert Laura , Barone Angelica , Tucci Fabio , Farruggia Piero , Petrone Angelamaria , Mondino Anna , Lo Valvo Laura , Crescenzio Nicoletta , Bellia Francesco , Olivieri Irene , Palmisani Elena , Caviglia Ilaria , Dufour Carlo , Fioredda Francesca 
Published: July 2016

SummaryMycophenolate mofetil (MMF) has been shown to be effective in children with immune thrombocytopenia (ITP) and Evans syndrome (ES), but data from larger series and details on the timing of the response are lacking. We evaluated 56 children treated with MMF for ITP (n = 40) or ES (n = 16), which was primary or secondary to autoimmune lymphoproliferative syndrome ‐related syndrome (ARS). Thirty‐five of the 54 evaluable patients (65%) achieved a partial (18%) or complete (46%) response after a median (range) of 20 (7–137) and 37 (7–192) d, respectively. ITP and ES patients responded in 58% and 81% of cases (P = not significant, ns), with complete response in 32% and 81% (P = 0·01), respectively. 60% and 73% of children with primary disease and ARS responded (P = ns) with complete response in 34% and 68% of cases (P = 0·01), respectively. Six of 35 (17%) children relapsed after a median of 283 d (range 189–1036). Limited toxicity was observed in four patients. The median durations of treatment and follow‐up were seven and 12·7 months, respectively. This is the largest reported cohort of patients treated with MMF for ITP/ES. The results show that MMF is effective and safe and provides a relatively quick response, suggesting that it has a potential role as an alternative to more aggressive and expensive second/further‐line treatments.
Structural commonality of C1q TNF‐related proteins and their potential to activate relaxin/insulin‐like family peptide receptor 1 signalling pathways in cancer cells
Authors: Klonisch Thomas , Glogowska Aleksandra , Thanasupawat Thatchawan , Burg Maxwell , Krcek Jerry , Pitz Marshall , Jaggupilli Appalaraju , Chelikani Prashen , Wong G William , Hombach‐Klonisch Sabine 
Published: July 2016

We established the role of the GPCR relaxin/insulin‐like family peptide receptor 1 (RXFP1 receptor) as a novel active receptor in human glioblastoma (GB), a fatal brain tumour. We identified C1q/TNF‐related protein 8 (CTRP8) as a novel agonist of the RXFP1 receptor. CTRP8 enhanced the motility and matrix invasion of GB, and this involved PKC‐mediated up‐regulation of cathepsin B, a marker for poor prognosis in GB patients. We conclude that the absence of relaxin isoforms does not preclude the activation of the RXFP1 receptor, as the least known member of the CTRP family, CTRP8, can effectively target and activate RXFP1 receptors.Linked ArticlesThis article is part of a themed section on Recent Progress in the Understanding of Relaxin Family Peptides and their Receptors. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.10/issuetoc