bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal Antihypertensive Systolic Blood Pressure: A Systematic Review and Meta-Analysis
Authors: Whelton Paul K. , O’Connell Samantha , Mills Katherine T. , He Jiang 
Published: September 2024

BACKGROUND:
Systolic blood pressure (SBP) lowering reduces major cardiovascular disease (CVD) and all-cause mortality. However, the optimal target for SBP lowering remains controversial.

METHODS:
We included trials with random allocation to an SBP <130 mm Hg treatment target and CVD as the primary outcome. Data were extracted from each study independently and in duplicate using a standardized protocol. Random-effects meta-analysis was used to obtain pooled hazard ratios (HRs) and 95% CIs for CVD and all-cause mortality comparing SBP <130 and ≥130 mm Hg treatment targets. A secondary analysis compared the same outcomes for randomization to an SBP target of <120 or <140 mm Hg.

RESULTS:
Seven trials, including 72 138 participants, met the eligibility criteria. Compared with an SBP target of ≥130 mm Hg, an SBP target of <130 mm Hg significantly reduced major CVD (HR, 0.78 [95% CI, 0.70–0.87]) and all-cause mortality (HR, 0.89 [95% CI, 0.79–0.99]). Compared with an SBP target of <140 mm Hg, an intensive SBP target of <120 mm Hg significantly reduced major CVD (HR, 0.82 [95% CI, 0.74–0.91]), but all-cause mortality was marginally insignificant (HR, 0.85 [95% CI, 0.71–1.01]). Adverse events were significantly more likely in the intensive SBP target groups, but the absolute risks were low.

CONCLUSIONS:
This study suggests targeting an SBP <130 mm Hg significantly reduces the risks of major CVD and all-cause mortality. The findings also support an SBP target of <120 mm Hg, based on a smaller number of trials.

REGISTRATION:

URL:
https://www.crd.york.ac.uk/PROSPERO/
; Unique identifier: CRD42023490693.
Screenwriting Applied to the Academic Study of Religion: Some Kind of Liberating Effect, a Documentary on Central and Eastern Europe
Authors: Severino Valerio 
Published: September 2024

Abstract
Some Kind of Liberating Effect is a documentary dedicated to research freedom in the academic study of religion in Central and Eastern Europe. This essay examines the techniques used to develop a script and a screenplay. It will show how the documentary integrates screenwriting with the question of freedom of research in this academic field and region. First, the essay presents the raw footage filmed between 2022 and 2023, then the screenwriting techniques used for plotting a story. Finally, it discusses the shift from the history of the academic field to storytelling, particularly with regard to the frame story included in the film. In conclusion, it presents some remarks concerning the interdisciplinary and intersectoral approaches between religious studies and the film industry implemented in the documentary.
Palestine, Futurity, and the Rithāʾ: A Poetics of Speculation and Proleptic Mourning
Authors: Kraver Stephanie 
Published: September 2024

Abstract
This paper explores Fadwā Ṭūqān’s and Maḥmūd Darwīsh’s poetry written in the wake of the 1967 June War, the Israeli siege of Beirut in 1982, and the Second Intifāḍah (uprising) in 2002. Specifically, the article investigates how the poets mobilize the Arabic elegiac (rithāʾ) genre, as well as pre-Islamic and early Islamic poetic traditions, in order to contemplate the future and foster a mode of proleptic mourning. This paper asserts that these two Palestinian poets utilize the longstanding elegiac form in Arabic literary heritage to not only summon and lament past events and atrocities, but to conjecture about the insecurity that they anticipate in the years to come. The poems render both hopeful and pessimistic sentiments and premonitions, demonstrating how the ongoing Israeli occupation and the Palestinians’ resultant losses over time have precipitated increasingly sobering and distressing speculations about the perpetuation of Palestinians’ grief in the future.
Prolegomenon for a Theory of the Palestinian American Novel
Authors: Schreier Benjamin 
Published: September 2024

Abstract
Though Palestine—as place, national aspiration, conflict, refugee crisis, political-cultural cause—stands at the institutional origin of the fields of Arab American literary study and Arab American studies more generally, Palestinian American literature itself has mostly not yet become a discrete object of disciplinary study. Palestinian American authors have not been ignored, but scholarly analysis of their work often proceeds under the authority of other legitimizing frameworks—with Palestinian American literature instrumentalized as capital for other ideological projects—even as identity became a primary currency in academic literary study in the decolonial era. This has limited opportunities to examine disciplinary mechanisms of institution-formation. A robust theory of Palestinian American literature contests the critical overdetermination suffered by an emergent Palestinian American literary archive that has expanded substantially since 2001, supporting a dynamic field of dedicated literary scholarship that refuses to be subordinated to a project of territorial nationalism.
The Role of Science in Society: The Researcher as Public Intellectual
Authors: Guimay Sandra Frost Campos , Rendtorff Jacob Dahl 
Published: September 2024

Abstract
What is the role of researchers in society? Can research be political? A heated debate in Denmark about activist research and pseudoscience raised many philosophical issues about the role of the scientist in society. In this article, we distinguish between different strands of this debate about activist research and the limits of academic freedom from the perspective of ethics and the philosophy of science. We begin by presenting some topics from the debate. Then we discuss perspectives from the ethics of science in relation to science and society, cancel culture, pseudoscience, demarcation, and academic freedom. Moreover, we analyze the ethical obligation of researchers to be public intellectuals as essential for ensuring the ethics and responsibility of science in democratic societies. Accordingly, we present the idea of the public intellectual proposed by Hannah Arendt as a justification for the protection of academic freedom and for the ethical responsibility of science in society.
Touching Parchment: How Medieval Users Rubbed, Handled, and Kissed Their Manuscripts
Authors: Rudy Kathryn M. 
Published: September 2024

In the late middle ages (ca. 1200-1520), both religious and secular people used manuscripts, was regarded as a most precious item. The traces of their use through touching and handling during different rituals such as oath-taking, public reading, and memorializing the dead, is the subject of Kathryn Rudy’s research in Touching Parchment.
This second volume, Social Encounters with the Book, delves into the physical interaction with books in various social settings, including education, courtly assemblies, and confraternal gatherings. Looking at acts such as pointing, scratching, and ‘wet-touching’, the author zooms in on smudges and abrasions on medieval manuscripts as testimonials of readers’ interaction with the book and its contents. In so doing, she dissects the function of books in oaths, confraternal groups, education, and courtly settings, illuminating how books were used as teaching aids and tools for conveying political messages. The narrative paints a vivid picture of medieval reading, emphasizing bodily engagement, from page-turning to the intimate act of kissing pages. Overall, this text offers a captivating exploration of the tactile and social dimensions of book use in late medieval Europe broadening our perspective on the role of objects in rituals during the middle ages. Social Encounters with the Book provides a fundamental resource to anybody interested in medieval history and book materiality more widely.
This volume is part of a four-volume set, with two additional titles forthcoming.
Chapter 2
Authors: Rudy Kathryn M. 
Published: September 2024

Chapter 2 considers the rituals and social functions of confraternities in the Middle Ages, focusing on the manuscripts used in their ceremonies and the physical interactions these books invited. It highlights how civic groups adopted ecclesiastical modes of oath-taking, blending verbal confirmations with the theatrical handling of significant objects, notably books. Images in some manuscripts, such as the Liber Regulae of the Order of the Holy Spirit from Rome, depict such ceremonies. Drawing on visual evidence as well as use-wear evidence, the chapter argues for the role of book-touching in forging bonds within confraternities.
The chapter further discusses the transition of confraternities from monastic to lay administration post-Black Death, with an increasing number of such brotherhoods forming for mutual support in life and remembrance after death. It specifically examines three case studies. The first, which treats the confraternity of St Nicholas in Valenciennes, provides insights into the social activities and obligations of its members, including their distinctive attire, communal feasts, and processional duties. This confraternity emphasizes the performative and public display of unity and piety, with detailed attention to the members' embodied participation.
The second and third case studies treat confraternities dedicated to St. Sebastian, a military saint revered for his perceived role in protecting against the plague and reforming knightly behavior. One group in Linkebeek (near Brussels) relied on ducal patronage. Members recorded their names as a form of social and spiritual affirmation. Despite the confraternity's close ties with the Burgundian court, its membership was highly inclusive. Nonetheless, members asserted their place in a social hierarchy by having their names written as close as possible to that of the founding duke. The third case study considers a confraternity at St Gorik's church in Brussels, which developed from an archery guild into a rhetoricians' guild. The manuscript associated with St Gorik's, laden with historical data, underscores the diverse membership and cultural impact of the confraternity within the broader context of Brussels socio-religious norms.
The chapter argues that the manuscripts and rituals of medieval confraternities played a pivotal role in forging social bonds and establishing collective identities. The physical marks and patterns of wear on the manuscripts serve as tangible evidence of these practices, revealing the importance of group cohesion and the performative nature of social and spiritual commitments in the late Middle Ages.
Chapter 5
Authors: Rudy Kathryn M. 
Published: September 2024

Chapter 5 considers the interplay between the living and the dead within the Christian tradition, focusing on the role of book-centered rituals in mediating this relationship. It underscores the Christian view of death as a gateway to the afterlife, emphasizing the intercessory role played by the living through prayer to aid the souls in Purgatory. The chapter examines the emergence of brotherhoods and the hiring of monastics as professional intercessors, a practice reflected in images, such as the Spes Nostra painting.
This chapter also explores the documentation of these practices, particularly through necrologies which record the obligations of prayer and remembrance, such as one owned by the Tertiaries of the Convent of St Lucy in Amsterdam. The marks on the page, made by many hands over time, highlights the interaction required to keep the record up-to-date as an enduring social practice.
Furthermore, the chapter analyzes the function and impact of mortuary rolls as tools for collective remembrance and contractual prayer obligations within religious communities, illustrated by the mortuary roll for the Abbey at Forest's Abbess Elisabeth ’sConincs. The roll's journey and the reciprocal prayer arrangements it facilitated reflect a complex spiritual economy, as well as the social and physical handling of these documents.
The chapter concludes by comparing the mortuary rolls to the letters of profession discussed earlier, emphasizing their role in collective authorship and social memory. It argues that the physical and communal interactions with these manuscripts—through reading, writing, and handling—are essential to their function as vehicles of collective memory and spiritual economy.
Recycling catfish bone for additive manufacturing of silicone composite structures
Authors: Aqerrout Saad , Wu Di , Yu Fei , Liu Wenbo , Han Yuke , Lyu Jiaqi , Jing Yi , Yang Xiaoran 
Published: September 2024

As a notable commercial aquaculture species, channel catfish ( Ictalurus punctatus) in US faces challenges including the global market competition and enhanced feed costs. Since fish bone waste is a major source of calcium and hydroxyapatite, re-utilization gives birth to several advanced products in the development of animal feed, fertilizers, and nutrition supplements. Recent research findings introduce fish bone powder (FBP) reinforcement in Fused Deposition Modeling (FDM) of plastic composites. However, FBP so far has not been widely utilized for Direct Ink Writing (DIW) 3D printing of silicone composite. In this paper, catfish bone waste has been recycled and processed with a thermal procedure. FBP reinforced silicone composite structures have been developed and manufactured using low-viscosity DIW 3D printing. Morphological and chemical structures of FBPs were analyzed and compared before and after calcination. The rheological and mechanical characterization have indicated the potential of calcinated FBP in advancing the silicone composites. With 0%–50% weight percentages of FBP, composite samples can be designed to get any specified mechanical response (0.5–1.4 MPa in 50% tension strain and 150–550 N in 30% compression strain). The shape holding, overhang, and dimensional accuracy of FBP reinforced silicone composites in single (DIW) and dual (FDM + DIW) 3D printing processes have been demonstrated and summarized. With appropriate adjustments, this FBP-based 3D printing technology can be applied to byproduct recycling of all the US food-fish species, poultry, and livestock.
The role of humerus cortical thickness in predicting osteoporosis in MR imaging
Authors: Emir Sevde Nur , Dereli Bulut Safiye Sanem 
Published: September 2024

Aim This study aims to evaluate the efficacy of humerus cortical thickness on coronal T1-weighted images of the humerus in distinguishing patients with normal vs. abnormal bone mineral density (BMD). Methods Patients (n:138) with shoulder magnetic resonance imaging (MRI) and dual-energy x-ray absorptiometry (DXA) scans were evaluated. Patients were grouped into normal and low BMD (osteopenia and osteoporosis) according to DXA. An average cortical bone thickness (CBTavg) and gauge cortical bone thickness (CBTg) were calculated from the proximal humerus on coronal T1W MRI. Sensitivity and specificity for the prediction of osteoporosis were determined for several cortical bone thickness thresholds. Results Proximal humerus average cortical bone thickness measurements strongly correlated with DXA femur and lumbar scores ( p < 0.01). Gauge cortical thickness measurements also correlated with DXA femur and lumbar scores ( p < 0.01). Average cortical bone thickness measurement of 4.52 mm was determined to be a potential marker for predicting osteoporosis, with a sensitivity of 92.3% and a specificity of 84.9%. Conclusion Average cortical bone thickness measurements obtained from shoulder MRI are correlated with DXA. It appears to be effective in differentiating patients with normal and abnormal BMD and may help to opportunistically predict patients with osteoporosis in a rapid, simple and practical way, potentially guiding further diagnostic assessments.
Feasibility of a noninvasive heart failure telemonitoring system: A mixed methods study
Authors: Ekola Teemu , Virtanen Vesa , Koskela Tuomas H 
Published: September 2024

Objective The aim of this study was to examine the feasibility of a noninvasive telemonitoring system used by heart failure patients and nurses in a pilot program of the Heart Hospital unit in Tampere, Finland. Methods This cross-sectional observational study used a mixed methods design. Quantitative data were collected with one self-generated questionnaire for patients, and qualitative data were collected with a questionnaire for patients and semi-structured focus group interviews for patients and nurses. The questionnaire was sent to 47 patients who were in the pilot program, and 29 patients (61.7%) responded. Purposefully selected 8 patients and 8 nurses attended the interviews. We used descriptive statistics to assess the quantitative data from the questionnaire and inductive thematic analysis to identify themes deriving from the focus group interviews. We categorized the themes into facilitators and barriers to telemonitoring. Results Both the quantitative and qualitative data show that the telemonitoring system is easy to use, supports self-care and self-monitoring, and increases the feeling of safety. The chat tool of the system facilitated communication. The patients and nurses considered the system reliable despite some technical problems. The focus group interviews addressed technical challenges, nurses’ increased workload, and patients’ engagement with daily follow-up as possible barriers to telemonitoring. Conclusions The noninvasive heart failure telemonitoring system used in the pilot program is feasible. We found facilitators and barriers to telemonitoring that should be considered when developing the noninvasive telemonitoring of heart failure in the future.
Acute exacerbations in patients with progressive pulmonary fibrosis
Authors: Kreuter Michael , Belloli Elizabeth A. , Bendstrup Elisabeth , Cerri Stefania , Flaherty Kevin R. , Shapera Shane , Song Jin Woo , Mueller Heiko , Rohr Klaus B. , Kondoh Yasuhiro ,   on behalf of the INBUILD trial investigators
Published: September 2024

BackgroundAcute exacerbations of fibrosing interstitial lung diseases (ILDs) are associated with high mortality. We used prospective data from the INBUILD trial to investigate risk factors for acute exacerbations and the impact of these events in patients with progressive pulmonary fibrosis.MethodsPatients with progressive fibrosing ILDs other than idiopathic pulmonary fibrosis (IPF) were randomised to receive nintedanib or placebo. Associations between baseline characteristics and time to first acute exacerbation were assessed using pooled data from both treatment groups using Cox proportional hazard models, firstly univariable models and then a multivariable model using forward stepwise selection. The risk of death was estimated based on the Kaplan−Meier method.ResultsOver a median follow-up of approximately 19 months, acute exacerbations were reported in 58 (8.7%) of 663 patients. In the risk factor analysis, the final model included diffusing capacity of the lung for carbon monoxide (DLCO) % predicted, treatment and age. LowerDLCO% predicted was associated with an increased risk of acute exacerbation with a hazard ratio (HR) of 1.56 (95% CI 1.21–2.02) per 10 units lower (p<0.001). Age ≥65 years was associated with a numerically increased risk (HR 1.55, 95% CI 0.87–2.77; p=0.14). Treatment with nintedanib conferred a numerically reduced riskversusplacebo (HR 0.60, 95% CI 0.35–1.02; p=0.06). The estimated risks of death ≤30 days and ≤90 days after an acute exacerbation were 19.0% (95% CI 8.9–29.2) and 32.0% (95% CI 19.7–44.2).ConclusionsAcute exacerbations of progressive pulmonary fibrosis may have similar risk factors and prognostic impact as acute exacerbations of IPF.
Facies variability and depositional cyclicity in central Northern Switzerland: insights from new Opalinus Clay drill cores
Authors: Zimmerli Géraldine N. , Wohlwend Stephan , Deplazes Gaudenz , Becker Jens , Wetzel Andreas , Francescangeli Fabio , Foubert Anneleen 
Published: September 2024

AbstractThe Opalinus Clay, a silty to sandy claystone formation, Early to Middle Jurassic (Toarcian and Aalenian) in age, has been selected as the host rock for deep subsurface disposal of radioactive waste in Switzerland. Over the past thirty years, numerous geotechnical, mineralogical, and sedimentological studies have been conducted on the Opalinus Clay within the framework of the Nagra (National Cooperative for the Disposal of Radioactive Waste) deep drilling campaigns and the Mont Terri Project, an international research program dedicated to the study of claystone. The present study aims to unravel the variability of the lateral and vertical facies of the Opalinus Clay in central Northern Switzerland and to place this variability in a regional and basinal context. Analyses of new cores drilled in central Northern Switzerland, including petrographic, mineralogical (X-ray diffraction, multi-mineral interpretation), geochemical (X-ray fluorescence), statistical (non-metric multidimensional scaling analysis), and bedding dip and azimuth data, shed new light on the depositional facies and the spatial and temporal variability of the Opalinus Clay. Petrographic descriptions encompass nine new drill cores using a revised subfacies/facies classification scheme based on texture (colour, grain size, bedding) and composition (mineralogy). Particularly, one new subfacies (SF6) is described and interpreted as mass-wasting deposits. The drill cores are correlated laterally using specific marker horizons. This correlation is achieved by combining thorough facies investigations with lithostratigraphy, biostratigraphy, and chemostratigraphy. Six to seven small coarsening-upward cycles and two long-term coarsening-upward sequences can be interpreted as regressive trends. The observed trends are influenced by the interplay between sediment supply, eustatic sea level change, synsedimentary subsidence, but also the palaeogeographic configuration in an epicontinental sea, provenance and delivery of sediments, current dynamics and climate change. Finally, combined results show that the current dynamics in the Opalinus Clay has been underestimated until now and new depositional models, including the occurrence of drift deposits, are discussed.
Longevity of hybrid immunity against SARS-CoV-2 in adults vaccinated with an adenovirus-based COVID-19 vaccine
Authors: Mvula Memory , Mtonga Fatima , Mandolo Jonathan , Jowati Chisomo , Kalirani Alice , Chigamba Precious , Lisimba Edwin , Mitole Ndaona , Chibwana Marah G. , Jambo Kondwani C. 
Published: September 2024

Abstract
Background
Hybrid immunity provides better protection against COVID-19 than vaccination or prior natural infection alone. It induces high magnitude and broadly cross-reactive neutralising anti-Spike IgG antibodies. However, it is not clear how long these potent antibodies last, especially in the context of adenovirus-based COVID-19 vaccines.

Methods
We conducted a longitudinal cohort study and enrolled 20 adults who had received an adenovirus-based COVID-19 vaccine before a laboratory-confirmed SARS-CoV-2 infection. We followed up the study participants for 390 days post the initial breakthrough infection. We assessed the longevity and cross-reactive breadth of serum antibodies against SARS-CoV-2 variants of concern (VOCs), including Omicron.

Results
The binding anti-Spike IgG antibodies remained within the reported putative levels for at least 360 days and were cross-neutralising against Beta, Gamma, Delta, and Omicron. During the follow up period, a median of one SARS-CoV-2 re-infection event was observed across the cohort, but none resulted in severe COVID-19. Moreover, the re-exposure events were associated with augmented anti-Spike and anti-RBD IgG antibody titres.

Conclusions
This study confirms that hybrid immunity provides durable broadly cross-reactive antibody immunity against SARS-CoV-2 variants of concern for at least a year (360 days), and that it is further augment by SARS-CoV-2 re-exposure.