bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of the ceRNA network mediated by lncRNA SNHG3 in the progression of cancer
Authors: Peng Ying , Long Xi-Dai 
Published: September 2024

Abstract
Background
Long non-coding RNAs (lncRNAs) are a distinct class of RNAs with longer than 200 base pairs that are not translated into proteins. Small Nucleolar RNA Host Gene 3 (SNHG3) is a lncRNA and frequently dysregulated in various human cancers.

Objective
This review provides a comprehensive analysis of current research on lncRNA SNHG3, focusing on its role within the competitive endogenous RNA (ceRNA) network and its implications in cancer.

Methods
A systematic literature review was conducted using PubMed up to October 2023. The search strategy included keywords such as “lncRNA SNHG3”, “competitive endogenous RNA”, “cancer”, and related terms. Studies were selected based on relevance to SNHG3's involvement in cancer pathogenesis and progression.

Results
Disruptions in the ceRNA network involving lncRNA SNHG3 can impair normal cell growth and differentiation, significantly contributing to disease pathogenesis, particularly cancer. This review highlights SNHG3's substantial impact on various cancer processes and its potential as a diagnostic and therapeutic tool for aggressive cancers.

Conclusion
The findings underscore SNHG3's pivotal role in cancer prevention, diagnosis, and treatment, laying a foundation for future research in cancer management. Insights from this review emphasize the necessity for further exploration and development of SNHG3-based diagnostic and therapeutic strategies.
Automated Provenance-Based Screening of ML Data Preparation Pipelines
Authors: Schelter Sebastian , Guha Shubha , Grafberger Stefan 
Published: September 2024

SummarySoftware systems that learn from data via machine learning (ML) are being deployed in increasing numbers in real world application scenarios. These ML applications contain complex data preparation pipelines, which take several raw inputs, integrate, filter and encode them to produce the input data for model training. This is in stark contrast to academic studies and benchmarks, which typically work with static, already prepared datasets. It is a difficult and tedious task to ensure at development time that the data preparation pipelines for such ML applications adhere to sound experimentation practices and compliance requirements. Identifying potential correctness issues currently requires a high degree of discipline, knowledge, and time from data scientists, and they often only implement one-off solutions, based on specialised frameworks that are incompatible with the rest of the data science ecosystem.We discuss how to model data preparation pipelines as dataflow computations from relational inputs to matrix outputs, and propose techniques that use record-level provenance to automatically screen these pipelines for many common correctness issues (e.g., data leakage between train and test data). We design a prototypical system to screen such data preparation pipelines and furthermore enable the automatic computation of important metadata such as group fairness metrics. We discuss how to extract the semantics and the data provenance of common artifacts in supervised learning tasks and evaluate our system on several example pipelines with real-world data.
Ervaringen en behoeften van jongeren in de (urologische) transitie naar volwassenheid/volwassenenzorg
Authors: van Wijk Iris , Kalsbeek C. J. C. Cecilia , Verrijt Neeltje , Been Max 
Published: September 2024

SamenvattingIn het Net als jij-project zijn de behoeften onderzocht van jongeren met een beperking in de overgang van kinderzorg naar volwassenenzorg en in de fase van het volwassen worden (12–25 jaar). Met deze informatie is in cocreatie met jongeren en ouders informatiemateriaal ontwikkeld waarin zij zich herkennen en dat aansluit bij hun behoeften. Al deze tools, ervaringsverhalen en aanvullende informatie staan op de openbare website www.netalsjij.nl en geven ook professionals handvatten om de zorg in de transitiefase voor jongeren met een beperking te verbeteren. In dit artikel delen Max en Neeltje (twee jongeren met spina bifida) hun ervaringen en tips.
Locus of Control, Learning Styles, and Academic Achievement of Saudi Pre-professional Medical Students: A Cross-sectional Study
Authors: Althubaiti Suha M. , Alharbi Nouf S. , Althubaiti Alaa , Alzahrani Amal , Agha Sajida 
Published: September 2024

Abstract

Objective
The objective of this study was to describe medical students’ learning styles and locus of control (LOC) and to determine their association with academic achievement.

Methods
A cross-sectional study was performed at a health science university in Saudi Arabia. A sample of 158 medical students completed Kolb’s learning style and locus of control scales. The authors measured academic achievement by grade point average (GPA) and collected demographic characteristics.

Results
Most students’ learning styles were classified as convergent (51.3%), whereas the rest adopted divergent (23.4%), accommodative (18.4%), and assimilative (7%) styles. Analysis revealed that students with a lower LOC tend to have higher GPAs than those with a higher LOC. However, no association was found between Kolb’s learning styles and LOC or GPA.

Conclusions
The findings of this study provide educators with essential insights into factors that enhance students’ academic achievements. We conclude that locus of control plays a crucial role in academic success. Medical educators should consider diverse student learning styles to adopt appropriate teaching methods that meet students’ needs, ultimately improving educational practices and outcomes in medical education.
Gendered Racial Microaggressions and Depressive Symptoms Among Emerging Adult Asian American Women: Racial/Ethnic Differences Among Asian and White Romantic Partners
Authors: Wong Michele J. , Keum Brian TaeHyuk , Nguyen Mary , Na Jung Yun 
Published: September 2024

AbstractDiscrimination can contribute to adverse mental health outcomes among individuals in romantic partnerships. However, research has yet to examine how differences in partner race/ethnicity can shape the link between gendered racial microaggressions, an intersectional form of discrimination, and depressive symptoms among Asian American women. Accordingly, we assessed the link between gendered racial microaggressions and depressive symptoms, and whether partner race/ethnicity (White vs. Asian) moderated the link. Using a sample of 156 Asian American women (Mage = 26.5, SD = 5.33), we conducted multiple regressions to assess the main effects between four gendered racial microaggression stress subscale factors and depressive symptoms. We then examined partner race/ethnicity as a moderator in these associations. All four gendered racial microaggression stress subscale factors of ascribed submissiveness, assumptions of universal appearance, Asian fetishism, and media invalidation significantly predicted greater depressive symptoms. However, only Asian fetishism experiences maintained a significant and positive association with depressive symptoms for Asian American women with White male partners. The association between Asian fetishism and depressive symptoms was no longer significant for Asian American women with Asian male partners. Results indicate that Asian fetishization may be a uniquely oppressive experience for Asian American women with White partners that can contribute to greater depressive symptoms. These findings demonstrate an increased need for the development of critical consciousness in individual and couples counseling sessions to help Asian American women and their romantic partners identify and mitigate the negative effects of gendered racial microaggressions.
Verbal Mediation During Auditory Equivalence Class Formation Using Go/No-Go Successive Matching-to-Sample
Authors: Dingus Charles S. , Hanson Robbie J. , Miguel Caio F. , Stern Sydney , Brand Denys 
Published: September 2024

AbstractSuccessive matching-to-sample (S-MTS) with a go/no-go response requirement has previously produced equivalence classes with nonverbal auditory stimuli among college students. When participants are required to talk aloud during posttests (protocol analysis), their verbal behavior tends to match their selection performance. However, in some cases, the protocol analysis seems to interfere with posttests, in that equivalence yields are lower when participants are required to talk aloud. Thus, the current study replicated and extended previous research by requiring participants to complete emergence posttests before introducing training for the protocol analysis. Subsequently, participants completed one additional block of the transitivity/equivalence posttest with the talk-aloud requirement. Additionally, participants completed tact and intraverbal tests following emergence posttests to further assess possible verbal-mediation strategies. The results showed that six of eight college students formed equivalence classes, suggesting that previous failures could have been influenced by the talk-aloud requirement. Further, there was a positive correlation between verbal and nonverbal (selection) responses suggesting the possibility that verbal mediation may have contributed to equivalence-class formation.
Cushing syndrome in paediatric population: who and how to screen
Authors: Chioma Laura , Patti Giuseppa , Cappa Marco , Maghnie Mohamad 
Published: September 2024

AbstractCushing’s syndrome (CS) is characterised by signs and symptoms resulting from excessive and prolonged exposure to exogenous glucocorticoids or endogenous hypercortisolism. In childhood, exogenous CS represents the main cause of CS due to the widespread therapeutic use of glucocorticoids, while endogenous CS is very rare and accounts for about 10% of CS cases. According to the origin of the hypercortisolism, the ACTH-dependent form due to pituitary ACTH-secreting tumours is the most common form of endogenous CS in paediatric age (about 75–80% of cases), following by adrenal causes (about 15–20% of cases) including adenoma, carcinoma (which has a peak of incidence in the first decade), bilateral adrenal hyperplasia or Carney complex, with a different distribution by age. Ectopic ACTH-secreting CS, genetic forms of pituitary adenomas are more uncommon. The insidious onset of hypercortisolism and the absence of salient early signs make the diagnosis of endogenous CS difficult. Facial changes, weight gain with simultaneous growth failure, prepubertal virilisation, or hypogonadism in adolescence represent some of the key features of CS. The diagnostic workup is essentially aimed at confirming hypercortisolism through screening tests whose diagnostic accuracy is not 100% and therefore the combination of more than two tests is mandatory to confirm the diagnosis of CS.
Einflussfaktoren auf die Rückkehr an den Arbeitsplatz nach Gewaltereignissen in Gesundheits- und Sozialberufen
Authors: Kozak Agnessa , Adler Mareike , Nienhaus Albert 
Published: September 2024

Zusammenfassung
Hintergrund
Beschäftigte in Gesundheits- und Sozialberufen sind häufig von Gewalt am Arbeitsplatz betroffen. Um eine erfolgreiche Rückkehr an den Arbeitsplatz nach einem traumatischen Gewaltereignis zu gewährleisten, kann eine nachhaltige Unterstützung erforderlich sein. Es fehlen jedoch Kenntnisse über die Einflussfaktoren, die diesen Prozess beeinflussen. Ziel ist es, förderliche und hinderliche Faktoren für die Rückkehr an den Arbeitsplatz zu identifizieren und Unterstützungsangebote aufzuzeigen.

Methodik
Für den Zeitraum von Januar 2000 bis August 2022 wurden in vier Datenbanken in Google Scholar sowie in Referenzlisten 115 Volltexte identifiziert. Davon wurden acht Studien in die thematische Analyse eingeschlossen, sechs mit einem qualitativen Design und zwei mit einem Mixed-Methods-Design.

Ergebnisse
Als förderliche Faktoren werden soziale Unterstützung durch Kolleginnen/Kollegen, Vorgesetzte oder Familienangehörige, Veränderungen der Arbeitsumgebung und -organisation zur Gewährleistung der Arbeitssicherheit sowie individuelle Bewältigungsstrategien zur Wiedererlangung des Sicherheitsgefühls und der Kontrolle über die Situation diskutiert. Zu den hinderlichen Faktoren zählen destruktive soziale Beziehungen im Team wie mangelndes Vertrauen oder Stigmatisierung. Auch fehlende Sicherheitsvorkehrungen und Nachsorgeangebote sowie ungünstig veränderte Arbeitsbedingungen, wie ein neuer Einsatzort oder neue Tätigkeiten, können die Rückkehr erschweren. Wir haben keine Studien zu betrieblichen Unterstützungsangeboten oder Rückkehrprogrammen identifiziert.

Diskussion
Diese Ergebnisse unterstreichen, dass die Rückkehr an den Arbeitsplatz nach Gewaltereignissen weitgehend unerforscht ist und sich in erster Linie auf die pflegerischen Berufe bezieht. Angesichts der hohen Prävalenz in diesen Branchen besteht dringender Handlungsbedarf, die Rückkehr an den Arbeitsplatz nach erlebten Gewaltereignissen intensiver zu erforschen und Maßnahmen zu entwickeln, die an den Bedürfnissen der Betroffenen und der Organisation ausgerichtet sind.
Mechanism of rockburst induced by the microseismic event in the floor strata of high tectonic stress zones: A case study
Authors: Wang Songwei , Cao Anye , Wang Changbin , Guo Wenhao , Xue Chengchun , Liu Jian-gang , Wu Xuesong , Shi Gangsheng 
Published: September 2024

AbstractWith the increase of mining scope, rockburst occurs frequently, but its generation mechanism has not been understood comprehensively. Based on a rockburst in the coal pillar area of high tectonic stress zones (HTSZs), this study analyzed the distribution characteristics of large-energy microseismic (MS) events by using data statistics. The mechanical cause of the MS event that induced the rockburst was revealed by means of seismic moment tensor inversion. On this basis, by using numerical simulation, this study explored the distribution characteristics of static load in rockburst area and the effect of dynamic load in the floor, and then proposed the rockburst mechanism. The results show that under the squeezing action, the floor strata in HTSZs implode and transmit energy outward in the form of stress waves. This causes the cumulative damage and stress of the coal body in the fast track of coal pillar area increase in a short time. Since the coal in this area has already been in the critical stress state, small stress changes may lead to coal failure and rockburst. In this case of rockburst, the high static load of coal is the main force source, and the dynamic load plays a role in increasing coal body damage and inducing rockburst. Combined with seismic moment tensor inversion and numerical simulation, this paper proposes a rockburst research scheme, which makes the simulation of dynamic load more reasonable. The results provide the theoretical basis for rockburst control under similar conditions.
A multi-criteria decision support framework for designing seismic and thermal resilient facades
Authors: Kim Kyujin , Luna-Navarro Alessandra , Ciurlanti Jonathan , Bianchi Simona 
Published: September 2024

AbstractFacades play a pivotal role in the performance of a building, serving various environmental, structural and operational functions. As climate-induced extreme events become more frequent, developing resilient facades is becoming crucial. Although facades can contribute significantly to the total post-disruption losses, their resilience is not sufficiently addressed in current design approaches. In response to this research gap, this study proposes a multi-criteria decision-making methodology to select optimal facade designs using resilience criteria: resilience loss and economic loss. The framework addresses the complexity of facade design, considering multiple hazards such as earthquakes and heatwaves. For seismic hazard, the facade’s resilience is defined as its ability to mitigate damage. In the case of heat hazard, resilience is assessed based on the ability to keep indoor conditions within a comfortable thermal range. To demonstrate the applicability of the proposed methodology, a case study of an 18-story office building in Izmir (Turkey) is used to compare alternative facade packages. These packages identify the facade design cases, each coupled with a dataset of seismic and thermal fragility curves. Numerical simulations are conducted to derive seismic and thermal resilience curves for each facade package, along with resilience criteria. These criteria are embedded into a practical decision-making process to enable the selection of the optimal design case based on project specifications.
Modulation of liver metabolism and gut microbiota by Alhagi-honey alleviated heat stress-induced liver damage
Authors: Xu Jing , Liu Yundie , Cao Xuanhong , Guo Xinrui , Wang Jie , Liu Yang , Zhou Hongda , Ma Baohua , Peng Sha 
Published: September 2024

AbstractAlhagi-honey (AH) is a well-established traditional ethnic medicine with advantageous effects against diarrhea and headaches. We aimed to explore the preventive effect of AH on liver damage induced by heat stress (HS) and its underlying mechanism. HS models were established by thermostat, and mice were treated at 39 ℃ for 10 h, lasting for 7 days. Hematoxylin–eosin (H&E) staining and Periodic Acid-Schiff (PAS) staining were used for histological observation, and transmission electron microscopy (TEM) was used for ultrastructure examination of hepatocytes. Gut microbiota (GM) composition and liver metabolites were respectively analyzed by 16S rRNA sequencing and non-targeted metabolome sequencing. AH pretreatment alleviated liver damage caused by heat stress in mice. The main manifestation was that AH alleviated serum aspartate transferase (AST) and aspartate transaminase (ALT). It was found that AH improved symptoms of hepatocyte damage. In addition, the relative abundance of f_Rikenellaceae, g_Incertae_Sedis and s_Staphylococcus_Orisratti, g_Lachnoclostridium, g_GCA-900066575, and s_Alistipes_inops were modified by AH and these bacterial genera showed association with 6 metabolites (2- (3,4-dihydroxyphenyl) acetamide, 3-hydroxy-3-methylpentanedioic acid, PC (17:0/17:1), Y-L-Glutamy-L-glutamic acid, L-Isoleucine, 5-Methyluridine, 8,8-dimethyl-2-phenyl-4H,8H-pyrano [2, 3-h] chromen-4-one). The Pearson analysis also showed a strong correlation between these microbes and 2 risk indicators (AST and ALT) of liver damage. AH alleviated HS-induced liver damage by regulating liver metabolism and maintaining normal GM. It demonstrated that AH held potential as a prophylactic drug for the prevention of HS-induced liver damage.
Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable
Authors: Bianchini Elisabetta , Roth Lynn , Boutouyrie Pierre , Badhwar Smriti , Schwarz Achim , Gemignani Vincenzo , Bruno Rosa Maria , Hametner Bernhard , Park Chloe , Pucci Giacomo , Mozos Ioana , Terentes-Printzios Dimitrios , Climie Rachel E. , Guala Andrea , Alastruey Jordi , Mayer Christopher C. 
Published: September 2024

Abstract
Translating vascular aging research from bench to bedside presents both significant opportunities and challenges. This paper summarizes insights from a roundtable discussion at the Artery 23 conference, featuring perspectives from basic science, clinical trials, regulation, and industry. The main conclusions of the discussion are as follows: basic science research must align with clinical relevance, using appropriate animal models and standardized measurement techniques. Pragmatic and registry-based clinical trials offer viable alternatives to traditional randomized controlled trials, facilitating real-world applicability. The regulatory landscape, particularly for software medical devices, must evolve to keep pace with technological advancements like artificial intelligence. Industry efforts focus on developing devices or solutions for vascular aging assessment and treatment strategies, yet face hurdles in large-scale adoption and reimbursement. Despite significant progress, the development of pharmacological interventions to mitigate vascular aging remains a critical need. This discussion underscores the importance of interdisciplinary collaboration to overcome barriers and translate scientific discoveries into clinical practice effectively.
Planning strategies and infrastructure development supporting physical activity: analyzing municipal compact city plans in Japan
Authors: Hino Kimihiro , Takeuchi Moe , Fukushima Keita , Kikuchi Hiroyuki , Inoue Shigeru , Lowe Melanie , Cerin Ester 
Published: September 2024

AbstractAligned with global goals for healthy and sustainable cities, urban compactness significantly promotes residents’ transport-related physical activity and health. In Japan, amid demographic changes, municipalities have begun formulating Location Normalization Plans focused on making cities more compact. This study examines the associations between health and transport-related physical activity considerations in urban plans, including Location Normalization Plans, the demographic characteristics of municipalities, and the development of infrastructure that supports leisure-time physical activity. Analyzing responses from 725 of 1,374 Japanese municipalities, our research reveals that 38% of urban plans integrated health and physical activity in goals/visions, and 28% recognized these as challenges. The development of physical activity infrastructure such as sports facilities (48%), metropolitan parks (21%), and bicycle paths (14%) was more prevalent in larger municipalities. However, the incorporation of health and physical activity in planning goals/visions or challenges was not exclusive to larger municipalities; smaller ones also demonstrated this capability. Logistic regression analyses revealed that municipalities that included health considerations in their plans’ goals/visions and challenges were more likely to develop or renovate physical activity infrastructure. Prioritizing health and physical activity in planning has the potential to support leisure-time and transport-related physical activity, helping to create healthy and sustainable cities.
Uniform Diophantine approximation and run-length function in continued fractions
Authors: TAN BO , ZHOU QING-LONG 
Published: September 2024

Abstract
We study the multifractal properties of the uniform approximation exponent and asymptotic approximation exponent in continued fractions. As a corollary, we calculate the Hausdorff dimension of the uniform Diophantine set

$$ \begin{align*} {\mathcal{U}(\hat{\nu})}= &\ \{x\in[0,1)\colon \text{for all }N\gg1,\text{ there exists }n\in[1,N],\\&\ \ \text{ such that }|T^{n}(x)-y| < |I_{N}(y)|^{\hat{\nu}}\} \end{align*} $$

for a class of quadratic irrational numbers

$y\in [0,1)$

. These results contribute to the study of the uniform Diophantine approximation, and apply to investigating the multifractal properties of run-length function in continued fractions.