bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Impact of Single Nucleotide Polymorphism in PD-L1 on Response to Nivolumab for Advanced Non-Small-Cell Lung Cancer Patients
Authors: Nomizo Takashi , Ozasa Hiroaki , Tsuji Takahiro , Funazo Tomoko , Yasuda Yuto , Yoshida Hironori , Yagi Yoshitaka , Sakamori Yuichi , Nagai Hiroki , Hirai Toyohiro , Kim Young Hak 
Published: March 2017

AbstractThis study was intended to determine the efficacy of nivolumab, we evaluated treatment response with respect to PD-1/PD-L1 SNPs among patients with NSCLC. A total of 50 patients with NSCLC were treated with nivolumab and were also evaluated for PD-1/PD-L1 single nucleotide polymorphisms (SNPs) from plasma DNA. We investigated the association among PD-1/PD-L1 SNPs, objective response rate (ORR) and progression-free survival (PFS). Two of seven SNPs studied showed association with ORR and PFS, with maximum evidence at the marker rs2282055. The ORR was 25%, 15%, and 0% for the G/G, G/T and T/T genotypes of PD-L1 rs2282055, respectively. The G allele of PD-L1 rs2282055 was significantly associated with better clinical response compared with the T allele (P = 0.0339 [Cochran-Armitage trend test]). The median PFS time was 2.6 months (95% confidence interval [CI], 1.8 months to 4.3 months) for the G/G and G/T genotypes and 1.8 months (95% confidence interval [CI], 0.4 months to 2.2 months) for the T/T genotype (P = 0.0163). Moreover, the C/C and C/G genotypes of PD-L1 rs4143815 were significantly associated with better ORR and PFS in NSCLC patients treated with nivolumab. These results suggest that rs2282055 and rs4143815 may be a biomarker for the efficacy of nivolumab.
Light controlled assembly of silver nanoparticles
Authors: Polywka Andreas , Tückmantel Christian , Görrn Patrick 
Published: March 2017

AbstractMetal nanoparticles show a particularly strong interaction with light, which is the basis for nanoparticle plasmonics. One of the main goals of this emerging research field is the alignment of nanoparticles and their integration into sophisticated nanostructures providing a tailored interaction with light. This assembly of nanoparticles at well-controlled substrate sites often involves expensive technological approaches, such as electron beam lithography in order to fabricate the nanoparticle structures. Furthermore difficult numerical simulations are needed to predict their optical properties. Both requirements, fabrication and prediction, complicate a cost-efficient exploitation of nanoparticle plasmonics in optoelectronic devices. Here we show that silver nanoparticles deposited under exposure to visible light arrange in a way that the resulting structure shows an optimized interaction with that light. This way, the light not only controls the nanoparticle alignment with an estimated accuracy of well below 20 nm during deposition from the liquid phase, but also defines the optical properties of the growing structure, and therefore complicated prediction is not needed.
Xeno-free culture of human pluripotent stem cells on oligopeptide-grafted hydrogels with various molecular designs
Authors: Chen Yen-Ming , Chen Li-Hua , Li Meng-Pei , Li Hsing-Fen , Higuchi Akon , Kumar S. Suresh , Ling Qing-Dong , Alarfaj Abdullah A. , Munusamy Murugan A. , Chang Yung , Benelli Giovanni , Murugan Kadarkarai , Umezawa Akihiro 
Published: March 2017

AbstractEstablishing cultures of human embryonic (ES) and induced pluripotent (iPS) stem cells in xeno-free conditions is essential for producing clinical-grade cells. Development of cell culture biomaterials for human ES and iPS cells is critical for this purpose. We designed several structures of oligopeptide-grafted poly (vinyl alcohol-co-itaconic acid) hydrogels with optimal elasticity, and prepared them in formations of single chain, single chain with joint segment, dual chain with joint segment, and branched-type chain. Oligopeptide sequences were selected from integrin- and glycosaminoglycan-binding domains of the extracellular matrix. The hydrogels grafted with vitronectin-derived oligopeptides having a joint segment or a dual chain, which has a storage modulus of 25 kPa, supported the long-term culture of human ES and iPS cells for over 10 passages. The dual chain and/or joint segment with cell adhesion molecules on the hydrogels facilitated the proliferation and pluripotency of human ES and iPS cells.
Significantly Enhanced Energy Storage Density by Modulating the Aspect Ratio of BaTiO3 Nanofibers
Authors: Zhang Dou , Zhou Xuefan , Roscow James , Zhou Kechao , Wang Lu , Luo Hang , Bowen Chris R. 
Published: March 2017

AbstractThere is a growing need for high energy density capacitors in modern electric power supplies. The creation of nanocomposite systems based on one-dimensional nanofibers has shown great potential in achieving a high energy density since they can optimize the energy density by exploiting both the high permittivity of ceramic fillers and the high breakdown strength of the polymer matrix. In this paper, BaTiO3 nanofibers (NFs) with different aspect ratio were synthesized by a two-step hydrothermal method and the permittivity and energy storage of the P(VDF-HFP) nanocomposites were investigated. It is found that as the BaTiO3 NF aspect ratio and volume fraction increased the permittivity and maximum electric displacement of the nanocomposites increased, while the breakdown strength decreased. The nanocomposites with the highest aspect ratio BaTiO3 NFs exhibited the highest energy storage density at the same electric field. However, the nanocomposites with the lowest aspect ratio BaTiO3 NFs achieved the maximal energy storage density of 15.48 J/cm3 due to its higher breakdown strength. This contribution provides a potential route to prepare and tailor the properties of high energy density capacitor nanocomposites.
Plasmonic metamaterial for electromagnetically induced transparency analogue and ultra-high figure of merit sensor
Authors: Wu Dong , Liu Yumin , Yu Li , Yu Zhongyuan , Chen Lei , Li Ruifang , Ma Rui , Liu Chang , Zhang Jinqiannan , Ye Han 
Published: March 2017

AbstractIn this work, using finite-difference time-domain method, we propose and numerically demonstrate a novel way to achieve electromagnetically induced transparency (EIT) phenomenon in the reflection spectrum by stacking two different types of coupling effect among different elements of the designed metamaterial. Compared with the conventional EIT-like analogues coming from only one type of coupling effect between bright and dark meta-atoms on the same plane, to our knowledge the novel approach is the first to realize the optically active and precise control of the wavelength position of EIT-like phenomenon using optical metamaterials. An on-to-off dynamic control of the EIT-like phenomenon also can be achieved by changing the refractive index of the dielectric substrate via adjusting an optical pump pulse. Furthermore, in near infrared region, the metamaterial structure can be operated as an ultra-high resolution refractive index sensor with an ultra-high figure of merit (FOM) reaching 3200, which remarkably improve the FOM value of plasmonic refractive index sensors. The novel approach realizing EIT-like spectral shape with easy adjustment to the working wavelengths will open up new avenues for future research and practical application of active plasmonic switch, ultra-high resolution sensors and active slow-light devices.
Variation in sensitivity of large benthic Foraminifera to the combined effects of ocean warming and local impacts
Authors: Prazeres Martina , Roberts T. Edward , Pandolfi John M. 
Published: March 2017

AbstractLarge benthic foraminifera (LBF) are crucial marine calcifiers in coral reefs, and sensitive to environmental changes. Yet, many species successfully colonise a wide range of habitats including highly fluctuating environments. We tested the combined effects of ocean warming, local impacts and different light levels on populations of the common LBF Amphistegina lobifera collected along a cross-shelf gradient of temperature and nutrients fluctuations. We analysed survivorship, bleaching frequency, chlorophyll a content and fecundity. Elevated temperature and nitrate significantly reduced survivorship and fecundity of A. lobifera across populations studied. This pattern was exacerbated when combined with below optimum light levels. Inshore populations showed a consistent resistance to increased temperature and nitrate levels, but all populations studied were significantly affected by light reduction. These findings demonstrated the capacity of some populations of LBF to acclimate to local conditions; nonetheless improvements in local water quality can ultimately ameliorate effects of climate change in local LBF populations.
Fine‐grained azimuthal direction of arrival estimation using received signal strengths
Authors: Maddio S. , Cidronali A. , Passafiume M. , Collodi G. , Maurri S. 
Published: March 2017

We propose a direction of arrival (DoA) estimation technique, which is enabled by a single printed patch antenna capable of four reconfigurable beams at the operative frequency of 2.45 GHz. The direction of the messages sent by a nomadic wireless node is estimated and stored without the need of lengthy offline measurements, by correlating the real‐time received signal strength actual data and the expected antenna beams. The comparison is implemented with a least square technique with an extremely reduced computational cost. Experimental validations demonstrate the DoA estimation capability, with a mean error <2.3° with a variance of 1.9° within a domain of 90°.
Energy director structure and self‐balancing jig for the ultrasonic bonding of microfluidic chips
Authors: Li Jingmin , Meng Fanjian , Liang Chao , Liu Chong 
Published: March 2017

Ultrasonic bonding was widely used to seal polymer microfludic chips due to its high strength, low cost and good biocompatibility. However, in the process of ultrasonic bonding, the easy clogging of microchannels and the difficulty of controlling microchannel heights limit the use of ultrasonic bonding in mass fabrication. In this study, energy director's structure including director protrusion, bonding limited platform and bonding pool is designed and used. A self‐balancing jig is designed to automatically adjust with the horn and produce an even bonding energy distribution. Ultrasonic bonding parameters including bonding pressure and bonding time are optimised. The tensile destruction test, leakage test and serum driving test are employed to measure the performance of the ultrasonic bonding chips. Results have shown that the energy director's structure and the self‐balancing jig can obviously reduce the clogging of microchannels and improve the uniformity of microchannel heights. By using the optimised bonding parameters, the bonding strength has reached >2.5 Mpa, and channel leakage has not been observed under 0.7 MPa air pressure. The energy director's structure and the self‐balancing jig presented here can provide an effective alternative for the mass ultrasonic bonding of microfluidic devices.
Pentalogy of Cantrell: Is Echocardiography Sufficient in the Neonatal Period?
Authors: Zani-Ruttenstock Elke , Zani Augusto , Honjo Osami , Chiu Priscilla 
Published: March 2017

AbstractPentalogy of Cantrell is a rare syndrome that is characterized by varying degrees of midline wall defects and congenital cardiac anomalies. A left ventricular diverticulum (LVD) is defined as partial ectopia cordis, can be part of the pentalogy of Cantrell, and can put the patient at risk of severe complications. Early diagnosis and ligation/resection of the LVD is important to prevent complications. We report on a case of pentalogy of Cantrell, in which a LVD was diagnosed only at 2 months of age despite preceding pre- and postnatal echocardiography. We conclude that in the suspicion of pentalogy of Cantrell, either complete or incomplete, cardiac magnetic resonance imaging should be performed, when possible, to avoid the potential complication of a herniating ventricular diverticulum.
Anreize für regionale Risikoselektion unter dem Morbiditätsorientierten Risikostrukturausgleich
Authors: Wende Danny 
Published: March 2017

Zusammenfassung
Die Einführung des GKV-FQWG sorgt für einen verstärkten Wettbewerbsdruck innerhalb des Systems der gesetzlichen Krankenkassen. Bestehen hohe Anreize zur Risikoselektion, so kann dieser Druck in einen vermehrten Kampf um vermeintlich vorteilhafte Versichertengruppen führen. Die Studie stellt heraus, welche Anreize zur regionalen Risikoselektion unter einem differenzierten Risikostrukturausgleichssystem vorliegen und gibt einen Einblick in die Bedeutung des Problemfeldes.
Bestimmung der regionalen Autokorrelation mittels Morans’I für Finanzkennzahlen des Risikostrukturausgleichsverfahrens.
Anreize zur regionalen Risikoselektion sind innerhalb der gesetzlichen Krankenversicherung vorhanden. Das Risikostrukturausgleichsverfahren reduziert die regionalen Kostencluster um 91% und trägt zur Vermeidung von Selektionsanreizen bei. Dennoch kann ein Zusammenhang zwischen der Wettbewerbsposition von Krankenkassen und deren geografischen Lage nachgewiesen werden (Korrelation -69,5%). Erst durch den Einsatz von regionalen Kontrollvariablen in der Ausgleichsregression kann die regionale Autokorrelation der Finanzergebnisse gänzlich vermieden werden.
Die aktuelle Ausgestaltung des Finanzausgleichssystems führt zu regionalen Ungleichgewichten, die zur Risikoselektion genutzt werden können und die Wettbewerbsposition der Krankenkassen beeinflussen.
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury
Authors: Pyzik Michal , Rath Timo , Kuo Timothy T. , Win Sanda , Baker Kristi , Hubbard Jonathan J. , Grenha Rosa , Gandhi Amit , Krämer Thomas D. , Mezo Adam R. , Taylor Zachary S. , McDonnell Kevin , Nienaber Vicki , Andersen Jan Terje , Mizoguchi Atsushi , Blumberg Laurence , Purohit Shalaka , Jones Susan D. , Christianson Greg , Lencer Wayne I. , Sandlie Inger , Kaplowitz Neil , Roopenian Derry C. , Blumberg Richard S. 
Published: March 2017

Significance
Neonatal crystallizable fragment receptor (FcRn) regulates immunity and homeostasis of the two most abundant circulating proteins, IgG and albumin. FcRn is expressed in hepatocytes, but hepatic FcRn function is unknown. We show that hepatic FcRn regulates albumin biodistribution. Absence of FcRn in the liver leads to hypoalbuminemia by preventing efficient albumin delivery into the circulation, causing albumin retention within hepatocytes and increasing biliary albumin excretion. Blockade of albumin–FcRn interactions protects liver from damage induced by acetaminophen, a hepatotoxin. This protection results from hepatocyte accumulation of albumin, which scavenges superoxide radicals, and from the redirection of albumin-bound acetaminophen into the bile. Therefore, FcRn-mediated homeostatic distribution of albumin into the bloodstream renders hepatocytes susceptible to acute hepatotoxin exposure, and inhibition of FcRn in the hepatocyte is protective.
Combining DNP NMR with segmental and specific labeling to study a yeast prion protein strain that is not parallel in-register
Authors: Frederick Kendra K. , Michaelis Vladimir K. , Caporini Marc A. , Andreas Loren B. , Debelouchina Galia T. , Griffin Robert G. , Lindquist Susan 
Published: March 2017

Significance
Self-propagating changes in the conformation of amyloidogenic proteins play vital roles in normal biology and disease. Despite intense research, the architecture of amyloid fibers remains poorly understood. In this work, we used both segmental and specific isotopic labeling schemes in combination with dynamic nuclear polarization (DNP) NMR to measure long-range interactions to distinguish between two models for the arrangement of monomers in amyloid fibers. These measurements enabled us to determine that the monomers in one variant of an amyloid form of NM do not adopt a parallel in-register arrangement. The combination of segmental and specific labeling schemes with DNP NMR enables the testing of structural models for systems for which it was previously impossible due to low experimental sensitivity.
Development of a Video Trawl Survey System for New England Groundfish
Authors: DeCelles Gregory R. , Keiley Emily F. , Lowery Travis M. , Calabrese Nicholas M. , Stokesbury Kevin D. E. 
Published: March 2017

AbstractUsing an iterative approach and extensive field testing we developed a new video trawl survey system that used a live‐feed video camera mounted in the cod end of a demersal trawl to record, identify, and quantify fish as they pass through the net. The majority of tows are made with an open cod end, allowing the fish to escape the net after being recorded by the camera. Periodically, closed cod end tows are made to collect biological samples and validate the video data. Eight field trials were conducted on Georges Bank and in the Gulf of Maine, and 229 h of video were recorded. The in‐trawl camera system performed reliably under harsh conditions in the field. Preliminary data analysis showed that the in‐trawl camera system can be used to count and identify roundfishes, such as Atlantic Cod Gadus morhua and Haddock Melanogrammus aeglefinus with a high degree of accuracy (97%), and the video can be used to calculate absolute abundance estimates. However, identifying flatfishes to the species level in the video was challenging, although improvements in identification rates were realized by modifying our camera system and lighting. This approach provides an alternative methodology to acquire abundance and distribution data for groundfish stocks. We described the iterative approach used to develop the video trawl system and discussed the future direction of the video processing and analysis.Received August 15, 2016; accepted January 9, 2017 Published online March 23, 2017
Insights on Mitochondrial Genetic Variation in Chesapeake Bay Summer‐Resident Cownose Rays
Authors: Carney Susan L. , McVeigh Doreen M. , Moss Jeanette B. , Ferrier M. Drew , Morrissey John F. 
Published: March 2017

AbstractThe Cownose Ray Rhinoptera bonasus has been hunted and fished without restrictions in the Chesapeake Bay in recent years despite minimal understanding of its population size or stability. We used genetics to characterize Cownose Rays from three locations in the Chesapeake Bay in an effort to better understand their population structure. The Chesapeake Bay individuals were compared with Cownose Ray samples from a location in their southern U.S. range, the Gulf of Mexico. Direct sequencing of 1,094 base pairs of two mitochondrial gene regions revealed 16 haplotypes with frequencies that were not significantly differentiated by collection site within the bay. Frequencies of haplotypes from the Gulf of Mexico (at Tampa, Florida) were significantly different from those at each of the Chesapeake Bay sites, supporting previous work that determined separate migratory patterns for Atlantic and Gulf of Mexico individuals. The possibility of sex‐specific patterns in genetic variation by sampling site remains to be determined. A more robust understanding of how genetic variation is distributed among locations and by sex in Cownose Rays will be essential in the event that management of the species becomes necessary.Received July 6, 2016; accepted January 18, 2017 Published online March 23, 2017
The Baptized Muse
Authors: Pollmann Karla 
Published: March 2017

Abstract
With the rise of Christianity in the Roman Empire, increasing numbers of educated people converted to this new belief. As Christianity did not have its own educational institutions, the issue of how to harmonize pagan education and Christian convictions became increasingly pressing. Especially classical poetry, the staple diet of pagan education, was considered morally corrupting (because of its deceitful mythological content) and damaging for the salvation of the soul (because of the false gods it advocated). But Christianity recoiled from an unqualified anti-intellectual attitude, while at the same time the experiment of creating an idiosyncratic form of genuinely Christian poetry failed (the sole exception being the poet Commodianus). This book argues that, instead, Christian poets made creative use of the classical literary tradition, and—in addition to blending it with Judaeo-Christian biblical exegesis—exploited poetry’s special ability of enhancing the effectiveness of communication through aesthetic means. It seeks to explore these strategies through a close analysis of a wide range of Christian, and for comparison partly also pagan, writers mainly from the fourth to sixth centuries. The book reveals that early Christianity was not a hermetically sealed uniform body, but displays a rich spectrum of possibilities in dealing with the past and a willingness to engage with and adapt the surrounding culture(s), thereby developing diverse and changing responses to historical challenges. By demonstrating throughout that authority is a key in understanding the long denigrated and misunderstood early Christian poets, this book reaches the ground-breaking conclusion that early Christian poetry is an art form that gains its justification by adding cultural authority to Christianity. Thus, in a wider sense this book engages with the recently emerged scholarly interest in aspects of religion as cultural phenomena.
Versifying Authoritative Prose
Authors: Pollmann Karla 
Published: March 2017

Abstract
The fourth-century Eucherius narrates in his Passio Acaunensium Martyrum that during the persecution under Diocletian a whole army of Christian soldiers suffered the martyr’s death at Acaunum in the Swiss Alps. His brief prose narrative had a rich reception which manifests itself in various hardly known poetic paraphrases. The versifications of Venantius Fortunatus, Walafrid Strabo, and Sigebert of Gembloux are analysed regarding their poetic technique, their literary intention, and socio-historical context. The chapter highlights the most important changes in these paraphrases in comparison with their prose hypotext. Particular attention is paid to the question whether, and, if so, to what extent, one can observe: (a) specific exegetical additions only possible because of the versification; and (b) significant changes regarding the paraphrastic technique and characteristics through the ages, namely, from late antiquity to the Middle Ages, as exemplified by the selected authors.
Christianity as Decadence or Progress in Pseudo-Hilary’s Paraphrastic Verse Summary of the History of Salvation
Authors: Pollmann Karla 
Published: March 2017

Abstract
Christianity favours a linear model of historical development, and has therefore an inherent interest in the notions of progress and decadence. Late antique Christianity partly takes inspiration from pagan classical models. But its archetypal textual matrix to elucidate the specifically Christian explanation of the purpose and meaning of history and the world is the creation narrative in the biblical book of Genesis which can be understood as an aetiological (foundation) story of the origins of the world and humanity. The fifth-century paraphrastic verse summary of the Bible by an anonymous poet (Pseudo-Hilary) confronts, similar to Proba (see Chapter 4), the creation narrative with selections from the New Testament in order to delineate a universal history of salvation. Most remarkably, this chapter illuminates the partly approving, partly critical usage of Lucretius whose Epicurean world-view was normally considered incompatible with Christian values.