bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Design of Mixed‐Metal Silver Decamolybdate Nanostructures for High Specific Energies at High Power Density.
Authors: Kumar Vipin , Matz Sebastian , Hoogestraat Dirk , Bhavanasi Venkateswarlu , Parida Kaushik , Al‐Shamery Katharina , Lee Pooi See 
Published: October 2016

AbstractTriclinic Ag6Mo10O33 nanorods are prepared by hydrothermal reaction of an aqueous solution of AgNO3 and (NH4)6Mo7O24 (pH 2 adjusted with HNO3, autoclave, 140 °C, 12 h).
ChemInform Abstract: Experimental and Theoretical Studies on the Crystal Structure of Ternary Copper Arsenides A2Cu3As3 (A: Sr, Eu).
Authors: Zhang Rong , Pan Ming‐Yan , Zhu Min , Tao Xu‐Tang , Xia Sheng‐Qing 
Published: October 2016

AbstractSingle crystals of the new compounds Sr2Cu3As3 and Eu2Cu3As3 are prepared in a Pb flux using a 3:2:5:25 molar mixture of Sr(Eu), Cu, As, and Pb (Al2O3 crucible in evacuated silica tubes, 900 °C, 20 h; cooling to 500 °C at a rate of 3 °C/h).
ChemInform Abstract: Hydrotrifluoromethylation of Unactivated Alkenes and Alkynes Enabled by an Electron‐Donor—Acceptor Complex of Togni′s Reagent with a Tertiary Amine.
Authors: Cheng Yuanzheng , Yu Shouyun 
Published: October 2016

AbstractThe existence of an electron‐donor↔acceptor (EDA) complex between Togni′s reagent and NMM as tertiary amine is supported by NMR titration experiments.
ChemInform Abstract: A General Catalyst for Site‐Selective C(sp3)—H Bond Amination of Activated Secondary over Tertiary Alkyl C(sp3)—H Bonds.
Authors: Scamp Ryan J. , Jirak James G. , Dolan Nicholas S. , Guzei Ilia A. , Schomaker Jennifer M. 
Published: October 2016

AbstractA newly designed silver complex generated in situ is applied to nitrene insertion into propargylic, allylic, and benzylic C—H bonds competing to tertiary alkyl C(sp3)—H bonds are reported.
ChemInform Abstract: Decarboxylative Cascade Reactions of Dihydroxyfumaric Acid: A Preparative Approach to the Glyoxylate Scenario.
Authors: Richter Celin , Berndt Falko , Kunde Tom , Mahrwald Rainer 
Published: October 2016

AbstractThe presented direct decarboxylative aldol reaction provides shortcuts for existing multistep routes to hydroxyketone structures found in natural products.
ChemInform Abstract: Rh‐Catalyzed [5 + 1] Cycloaddition of Allenylcyclopropanes and CO: Reaction Development and Application to the Formal Synthesis of (‐)‐Galanthamine.
Authors: Liu Cheng‐Hang , Yu Zhi‐Xiang 
Published: October 2016

AbstractThe reaction tolerates mono, di, and trisubstituted allenylcyclopropanes which may contain functionalized aryl or alkyl substituents.
ChemInform Abstract: Copper‐Catalyzed Electrophilic Amination Using N‐Methoxyamines.
Authors: Fukami Yutaro , Wada Takamasa , Meguro Tatsuhiko , Chida Noritaka , Sato Takaaki 
Published: October 2016

AbstractCopper‐catalyzed electrophilic amination of a triarylboroxin using an N‐methoxyamine to give quick access to a variety of anilines is reported.
ChemInform Abstract: Synthesis of Fluorenes Starting from 2‐Iodobiphenyls and CH2Br2 Through Palladium‐Catalyzed Dual C—C Bond Formation.
Authors: Shi Guangfa , Chen Dushen , Jiang Hang , Zhang Yu , Zhang Yanghui 
Published: October 2016

AbstractA facile and efficient approach to fluorenes is demonstrated.
ChemInform Abstract: Double Cyclization of O‐Acylated Hydroxyamides Generates 1,6‐Dioxa‐3,9‐diazaspiro[4.4]nonanes a New Class of Oxy‐oxazolidinones.
Authors: Nazarian Zohreh , Forsyth Craig 
Published: October 2016

AbstractNew diazaspirononanes are synthesized employing excess amounts of reagents, whereas using stoichiometric amounts of reagents leads to silyl carbamates.
ChemInform Abstract: Catalytic Asymmetric Formal γ‐Allylation of Deconjugated Butenolides
Authors: Simlandy Amit K. , Mukherjee Santanu 
Published: October 2016

Abstractbased on a two‐step protocol involving a catalytic diastereo‐ and enantioselective vinylogous nucleophilic addition to vinyl sulfones and Julia—Kocienski olefination
ChemInform Abstract: Regio‐ and Stereoselective Synthesis of Dithiocarbonates under Ambient and Solvent‐Free Conditions.
Authors: Diebler Johannes , Spannenberg Anke , Werner Thomas 
Published: October 2016

AbstractApplication of lithium tert‐butoxide as an efficient catalyst for the reaction of terminal as well as internal epoxides with carbon disulfides to dithiocarbonates is described.
ChemInform Abstract: I2 Mediated Synthesis of 5‐Substituted‐3‐methyl/benzyl‐1,3,4‐oxadiazol‐2(3H)‐ones via Sequential Condensation/Oxidative Cyclization and Rearrangement
Authors: Patel Shyam Sunder , Chandna Nisha , Kumar Shreemoyee , Jain Nidhi 
Published: October 2016

Abstractfrom readily available carbazates and aldehydes under transition‐metal‐free conditions
ChemInform Abstract: Amidines for Versatile Cobalt(III)‐Catalyzed Synthesis of Isoquinolines Through C—H Functionalization with Diazo Compounds.
Authors: Li Jie , Tang Mengyao , Zang Lei , Zhang Xiaolei , Zhang Zhao , Ackermann Lutz 
Published: October 2016

AbstractThe novel cobalt‐catalyzed aminoisoquinoline synthesis proceeds by C—H/N—H bond functionalization on aryl amidines with diazo compounds.
ChemInform Abstract: Tandem Rh(III)‐Catalyzed C—H Amination/Annulation Reactions: Synthesis of Indoloquinoline Derivatives in Water.
Authors: Shi Liangliang , Wang Baiquan 
Published: October 2016

AbstractWater is found to be an efficient solvent for the Rh‐catalyzed domino cyclization reaction of indoles with isoxazoles to yield indoloquinolines.
ChemInform Abstract: Organocatalytic Silyl Transfer from Silylborane to Nitroalkenes for the Synthesis of β‐Silyl Nitroalkanes and β‐Silyl Amines.
Authors: Jiang Chen‐Ran , Zhao Chun‐Liang , Guo Hui‐Fang , He Wei 
Published: October 2016

AbstractNovel Si—B activation by acid/base organocatalysis, which leads to a generally efficient silyl transfer to nitroalkenes is developed.
ChemInform Abstract: Studies on the Synthesis of Novel Four‐Membered Cyclic Oxaphosphetanes via Intramolecular Mitsunobu Reaction of Bishydroxyalkylphosphinic Acids.
Authors: Kaboudin Babak , Haghighat Hamideh , Yokomatsu Tsutomu 
Published: October 2016

AbstractBoth rac and meso substrates give the cis products (II).
ChemInform Abstract: Darwinolide, a New Diterpene Scaffold That Inhibits Methicillin‐Resistant Staphylococcus aureus Biofilm from the Antarctic Sponge Dendrilla membranosa.
Authors: von Salm Jacqueline L. , Witowski Christopher G. , Fleeman Renee M. , McClintock James B. , Amsler Charles D. , Shaw Lindsey N. , Baker Bill J. 
Published: October 2016

AbstractDarwinolide (I) shows cytotoxic activity.
ChemInform Abstract: Efficient Synthesis of Anastrephin via the Allylic Substitution for Quaternary Carbon Construction.
Authors: Wada Kyohei , Sakai Masahiro , Kawashima Hidehisa , Ogawa Narihito , Kobayashi Yuichi 
Published: October 2016

Abstract(‐)‐Anastrephin (I) is synthesized in 5.5% yield over 15 steps with 91% d.s.
ChemInform Abstract: Reactions of Metal Cluster Anions with Inorganic and Organic Molecules in the Gas Phase
Authors: Zhao Yan‐Xia , Liu Qing‐Yu , Zhang Mei‐Qi , He Sheng‐Gui 
Published: October 2016

AbstractReview: study of gas phase reactions by state‐of‐the‐art mass spectrometric experimentin conjunction with quantum chemical calculations; 248 refs.
Structure–Activity Relationships of 2‐Sufonylpyrimidines as Quorum‐Sensing Inhibitors to Tackle Biofilm Formation and eDNA Release of Pseudomonas aeruginosa
Authors: Thomann Andreas , Brengel Christian , Börger Carsten , Kail Dagmar , Steinbach Anke , Empting Martin , Hartmann Rolf W. 
Published: October 2016

AbstractDrug‐resistant Pseudomonas aeruginosa (PA) strains are on the rise, making treatment with current antibiotics ineffective. Hence, circumventing resistance or restoring the activity of antibiotics by novel approaches is of high demand. Targeting the Pseudomonas quinolone signal quorum sensing (PQS‐QS) system is an intriguing strategy to abolish PA pathogenicity without affecting the viability of the pathogen. Herein we report the structure–activity relationships of 2‐sulfonylpyrimidines, which were previously identified as dual‐target inhibitors of the PQS receptor PqsR and the PQS synthase PqsD. The SAR elucidation was guided by a combined approach using ligand efficiency and ligand lipophilicity efficiency to select the most promising compounds. In addition, the most effective inhibitors were rationally modified by the guidance of QSAR using Hansch analyses. Finally, these inhibitors showed the capacity to decrease biofilm mass and extracellular DNA, which are important determinants for antibiotic resistance.
Estimating regimen‐specific costs of chemotherapy for breast cancer: Observational cohort study
Authors: Giordano Sharon H. , Niu Jiangong , Chavez‐MacGregor Mariana , Zhao Hui , Zorzi Daria , Shih Ya‐Chen Tina , Smith Benjamin D. , Shen Chan 
Published: October 2016

BACKGROUNDOne goal for high‐quality patient care is communicating treatment costs to patients, yet cost information can be elusive. This is especially relevant for breast cancer care, for which numerous guideline‐concordant adjuvant chemotherapy regimens exist. The objective of the current study was to generate cost estimates for such regimens from payers’ and patients’ perspectives in a large, insured US population.METHODSAdult women who had incident breast cancer diagnosed between 2008 and 2012 (from the MarketScan database), had no secondary malignancy within 1 year of diagnosis, and received chemotherapy within 3 months of diagnosis were included (n = 14,643). Total and out‐of‐pocket costs were calculated using all claims within 18 months of diagnosis and were normalized to 2013 US dollars. The extended estimating equations method was used to assess cost by regimen adjusting for demographic and clinical factors.RESULTSAmong patients who did and did not receive trastuzumab, the median insurance payments were $160,590 and $82,260, respectively, and the median out‐of‐pocket payments were $3381 and $2724, respectively. Among patients who did not receive trastuzumab, 25% paid more than $4712, and 10% of patients paid more than $7041. For patients who did receive trastuzumab, 25% paid more than $5604, and 10% paid more than $8384. Among patients who were covered by high‐deductible health plans, the median out‐of‐pocket cost was $5158, 25% paid at least $8128, and 10% paid ≥ $11,344.CONCLUSIONSThe costs of breast cancer chemotherapy vary widely across regimens, and patients bear a substantial out‐of‐pocket burden. Cancer 2016;122:3447–3455. © 2016 American Cancer Society
Informed decision making before prostate‐specific antigen screening: Initial results using the American Cancer Society (ACS) Decision Aid (DA) among medically underserved men
Authors: Gökce Mehmet I. , Wang Xuemei , Frost Jacqueline , Roberson Pamela , Volk Robert J. , Brooks Durado , Canfield Steven E. , Pettaway Curtis A. 
Published: October 2016

BACKGROUNDThe American Cancer Society (ACS) recommends men have the opportunity to make an informed decision about screening for prostate cancer (PCa). The ACS developed a unique decision aid (ACS‐DA) for this purpose. However, to date, studies evaluating the efficacy of the ACS‐DA are lacking. The authors evaluated the ACS‐DA among a cohort of medically underserved men (MUM).METHODSA multiethnic cohort of MUM (n = 285) was prospectively included between June 2010 and December 2014. The ACS‐DA was presented in a group format. Levels of knowledge on PCa were evaluated before and after the presentation. Participants' decisional conflict and thoughts about the presentation also were evaluated. Logistic regression analyses were performed to determine factors associated with having an adequate level of knowledge.RESULTSBefore receiving the ACS‐DA, 33.1% of participants had adequate knowledge on PCa, and this increased to 77% after the DA (P < .0001). On multivariate analysis, higher education level (odds ratio, 11.19; P = .001) and history of another cancer (odds ratio, 7.45; P = .03) were associated with having adequate knowledge after receiving the DA. Levels of decisional conflict were low and were correlated with levels of knowledge after receiving the DA. The majority of men also rated the presentation as favorable and would recommend the ACS‐DA to others.CONCLUSIONSUse of the ACS‐DA was feasible among MUM and led to increased PCa knowledge. This also correlated with low levels of decisional conflict. The ACS‐DA presented to groups of men may serve as a feasible tool for informed decision making in a MUM population. Cancer 2017;123:583–591. © 2016 American Cancer Society.
Measuring financial toxicity as a clinically relevant patient‐reported outcome: The validation of the COmprehensive Score for financial Toxicity (COST)
Authors: de Souza Jonas A. , Yap Bonnie J. , Wroblewski Kristen , Blinder Victoria , Araújo Fabiana S. , Hlubocky Fay J. , Nicholas Lauren H. , O'Connor Jeremy M. , Brockstein Bruce , Ratain Mark J. , Daugherty Christopher K. , Cella David 
Published: October 2016

BACKGROUNDCancer and its treatment lead to increased financial distress for patients. To the authors' knowledge, to date, no standardized patient‐reported outcome measure has been validated to assess this distress.METHODSPatients with AJCC Stage IV solid tumors receiving chemotherapy for at least 2 months were recruited. Financial toxicity was measured by the COmprehensive Score for financial Toxicity (COST) measure. The authors collected data regarding patient characteristics, clinical trial participation, health care use, willingness to discuss costs, psychological distress (Brief Profile of Mood States [POMS]), and health‐related quality of life (HRQOL) as measured by the Functional Assessment of Cancer Therapy: General (FACT‐G) and the European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaires. Test‐retest reliability, internal consistency, and validity of the COST measure were assessed using standard‐scale construction techniques. Associations between the resulting factors and other variables were assessed using multivariable analyses.RESULTSA total of 375 patients with advanced cancer were approached, 233 of whom (62.1%) agreed to participate. The COST measure demonstrated high internal consistency and test‐retest reliability. Factor analyses revealed a coherent, single, latent variable (financial toxicity). COST values were found to be correlated with income (correlation coefficient [r] = 0.28; P<.001), psychosocial distress (r = ‐0.26; P<.001), and HRQOL, as measured by the FACT‐G (r = 0.42; P<.001) and by the EORTC QOL instruments (r = 0.33; P<.001). Independent factors found to be associated with financial toxicity were race (P = .04), employment status (P<.001), income (P = .003), number of inpatient admissions (P = .01), and psychological distress (P = .003). Willingness to discuss costs was not found to be associated with the degree of financial distress (P = .49).CONCLUSIONSThe COST measure demonstrated reliability and validity in measuring financial toxicity. Its correlation with HRQOL indicates that financial toxicity is a clinically relevant patient‐centered outcome. Cancer 2017;123:476–484. © 2016 American Cancer Society.
Mammography decision making: Trends and predictors of provider communication in the Health Information National Trends Survey, 2011 to 2014
Authors: Spring Laura M. , Marshall Megan R. , Warner Erica T. 
Published: October 2016

BACKGROUNDIn 2009, the US Preventive Services Task Force recommended that the decision to initiate screening mammography before age 50 years should be individualized. Herein, the authors examined whether health care providers are communicating regarding mammography decision making with women and whether communication is associated with screening behavior.METHODSData were drawn from the 2011 to 2014 Health Information National Trends Survey (HINTS). A total of 5915 female respondents aged ≥ 40 years who responded to the following question were included: “Has a doctor or other health professional ever told you that you could choose whether or not to have a mammogram?” We used logistic regression to generate odds ratios (ORs) and 95% confidence intervals (95% CIs) for predictors of provider communication and assessed whether provider communication was associated with mammography in the previous 2 years overall and stratified by age.RESULTSFewer than 50% of the women reported provider communication regarding mammogram choice. Women who reported provider communication were not found to be more likely to report no mammogram within the past 2 years (OR, 1.07; 95% CI, 0.87‐1.31) compared with those who did not. When stratified by 10‐year age group, provider communication was associated with a higher likelihood of no mammogram only among women age ≥70 years (OR, 1.64; 95% CI, 1.15‐2.34), and was associated with a lower likelihood of no mammogram only among women aged 40 to 49 years (OR, 0.63; 95% CI, 0.43‐0.92).CONCLUSIONSBetween 2011 and 2014, less than one‐half of women received communication regarding mammogram choice despite recommendations from the US Preventive Services Task Force. Provider communication regarding mammogram choice can influence screening behavior, particularly for younger and older women. Cancer 2017;123:401–409. © 2016 American Cancer Society.
A comparison of overall survival for patients with T4 larynx cancer treated with surgical versus organ‐preservation approaches: A National Cancer Data Base analysis
Authors: Stokes William A. , Jones Bernard L. , Bhatia Shilpa , Oweida Ayman J. , Bowles Daniel W. , Raben David , Goddard Julie A. , McDermott Jessica D. , Karam Sana D. 
Published: October 2016

BACKGROUNDAlthough laryngectomy is the treatment of choice for patients with T4 larynx cancer, many patients are unable or unwilling to undergo laryngectomy and instead pursue larynx‐preservation strategies combining radiotherapy (RT) and chemotherapy. Herein, the authors analyzed the National Cancer Data Base to evaluate overall survival (OS) between patients treated with surgical and organ‐preserving modalities.METHODSThe National Cancer Data Base was queried for patients diagnosed from 2004 through 2012 with T4M0 laryngeal cancer who underwent either laryngectomy (surgery) with adjuvant RT (SRT), chemotherapy starting concurrently within 7 days of RT (CCRT), or multiagent induction chemotherapy starting 43 to 98 days before RT (ICRT). Multivariate analysis and propensity score matching were used to explore the association between the intervention and OS. Recursive partitioning analysis was performed to identify groups benefiting from particular modalities.RESULTSA total of 1559 patients who underwent SRT, 1597 patients who underwent CCRT, and 386 patients who underwent ICRT were included. Adjusting for covariates, CCRT was found to be associated with inferior OS compared with SRT (hazard ratio [HR], 1.55; 95% confidence interval [95% CI], 1.41‐1.70 [P<.01]) and with ICRT (HR, 1.25; 95% CI, 1.07‐1.45 [P<.01]). OS among the patients treated with SRT did not appear to differ significantly from that of the ICRT cohort (HR, 0.87; 95% CI, 0.73‐1.03 [P =  0.10]), a finding confirmed with propensity score matching. Recursive partitioning analysis identified no subset of patients that derived an OS benefit from either approach over the other.CONCLUSIONSOS among patients undergoing SRT was found to be superior to that of patients treated with CCRT but did not significantly differ from that of those undergoing ICRT. Because these intriguing findings require validation, SRT should remain the standard of care for patients with this disease. However, organ preservation with ICRT may be a reasonable alternative in certain patients. Cancer 2017;123:600–608. © 2016 American Cancer Society.
COSMIC: High‐Resolution Cancer Genetics Using the Catalogue of Somatic Mutations in Cancer
Authors: Forbes S.A. , Beare D. , Bindal N. , Bamford S. , Ward S. , Cole C.G. , Jia M. , Kok C. , Boutselakis H. , De T. , Sondka Z. , Ponting L. , Stefancsik R. , Harsha B. , Tate J. , Dawson E. , Thompson S. , Jubb H. , Campbell P.J. 
Published: October 2016

AbstractCOSMIC (http://cancer.sanger.ac.uk) is an expert‐curated database of somatic mutations in human cancer. Broad and comprehensive in scope, recent releases in 2016 describe over 4 million coding mutations across all human cancer disease types. Mutations are annotated across the entire genome, but expert curation is focused on over 400 key cancer genes. Now encompassing the majority of molecular mutation mechanisms in oncogenetics, COSMIC additionally describes 10 million non‐coding mutations, 1 million copy‐number aberrations, 9 million gene‐expression variants, and almost 8 million differentially methylated CpGs. This information combines a consistent interpretation of the data from the major cancer genome consortia and cancer genome literature with exhaustive hand curation of over 22,000 gene‐specific literature publications. This unit describes the graphical Web site in detail; alternative protocols overview other ways the entire database can be accessed, analyzed, and downloaded. © 2016 by John Wiley & Sons, Inc.
Pronuclear Injection‐Based Targeted Transgenesis
Authors: Schilit Samantha L.P. , Ohtsuka Masato , Quadros Rolen M. , Gurumurthy Channabasavaiah B. 
Published: October 2016

AbstractMicroinjection of DNA expression cassettes into fertilized zygotes has been a standard method for generating transgenic animal models. While efficient, the injected DNA integrates randomly into the genome, leading to potential disruption of endogenous genes or regulatory elements, variation in copy number, or integration into heterochromatic regions that inhibit transgene expression. A recently developed method addresses such pitfalls of traditional transgenesis by targeting the transgene to predetermined sites in the genome that can safely harbor exogenous DNA. This method, called Pronuclear Injection‐based Targeted Transgenesis (PITT), employs an enzymatic transfer of exogenous DNA from a donor vector to a previously created landing‐pad site in the mouse genome. DNA transfer is achieved using molecular tools such as the Cre‐LoxP recombinase and PhiC31‐attB/P integrase systems. Here, we provide protocols for performing PITT and an overview of the current PITT tools available to the research community. © 2016 by John Wiley & Sons, Inc.
Analysis of Heritability Using Genome‐Wide Data
Authors: Hall Jacob B. , Bush William S. 
Published: October 2016

AbstractMost analyses of genome‐wide association data consider each variant independently without considering or adjusting for the genetic background present in the rest of the genome. New approaches to genome analysis use representations of genomic sharing to better account for confounding factors like population stratification or to directly approximate heritability through the estimated sharing of individuals in a dataset. These approaches use mixed linear models, which relate genotypic sharing to phenotypic sharing, and rely on the efficient computation of genetic sharing among individuals in a dataset. This unit describes the principles and practical application of mixed models for the analysis of genome‐wide association study data. © 2016 by John Wiley & Sons, Inc.
Transcriptome Analysis at the Single‐Cell Level Using SMART Technology
Authors: Fish Rachel N. , Bostick Magnolia , Lehman Alisa , Farmer Andrew 
Published: October 2016

AbstractRNA sequencing (RNA‐seq) is a powerful method for analyzing cell state, with minimal bias, and has broad applications within the biological sciences. However, transcriptome analysis of seemingly homogenous cell populations may in fact overlook significant heterogeneity that can be uncovered at the single‐cell level. The ultra‐low amount of RNA contained in a single cell requires extraordinarily sensitive and reproducible transcriptome analysis methods. As next‐generation sequencing (NGS) technologies mature, transcriptome profiling by RNA‐seq is increasingly being used to decipher the molecular signature of individual cells. This unit describes an ultra‐sensitive and reproducible protocol to generate cDNA and sequencing libraries directly from single cells or RNA inputs ranging from 10 pg to 10 ng. Important considerations for working with minute RNA inputs are given. © 2016 by John Wiley & Sons, Inc.