bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noncontact and Nonintrusive Microwave-Microfluidic Flow Sensor for Energy and Biomedical Engineering
Authors: Zarifi Mohammad Hossein , Sadabadi Hamid , Hejazi S. Hossein , Daneshmand Mojgan , Sanati-Nezhad Amir 
Published: January 2018

AbstractA novel flow sensor is presented to measure the flow rate within microchannels in a real-time, noncontact and nonintrusive manner. The microfluidic device is made of a fluidic microchannel sealed with a thin polymer layer interfacing the fluidics and microwave electronics. Deformation of the thin circular membrane alters the permittivity and conductivity over the sensitive zone of the microwave resonator device and enables high-resolution detection of flow rate in microfluidic channels using non-contact microwave as a standalone system. The flow sensor has the linear response in the range of 0–150 µl/min for the optimal sensor performance. The highest sensitivity is detected to be 0.5 µl/min for the membrane with the diameter of 3 mm and the thickness of 100 µm. The sensor is reproducible with the error of 0.1% for the flow rate of 10 µl/min. Furthermore, the sensor functioned very stable for 20 hrs performance within the cell culture incubator in 37 °C and 5% CO2 environment for detecting the flow rate of the culture medium. This sensor does not need any contact with the liquid and is highly compatible with several applications in energy and biomedical engineering, and particularly for microfluidic-based lab-on-chips, micro-bioreactors and organ-on-chips platforms.
In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
Authors: Khan Imran , Bahuguna Ashutosh , Kumar Pradeep , Bajpai Vivek K. , Kang Sun Chul 
Published: January 2018

AbstractCarvacrol is present abundantly in the essential oils of many medicinal plants and well known for its numerous biological activities. Since partial solubility in water and physicochemical instability limits its industrial uses, the present study was performed to prepare a carvacrol nanoemulsion (CANE) using an ultrasonication technique and further evaluation of its anticancer potential against human lung adenocarcinoma A549 cells. The nanoemulsion formulation was optimized by varying carvacrol and polysorbate 80 ratios and characterized by dynamic light scattering (DLS), which revealed a negative surface charge with a mean droplet size between 105.5 ± 3.4 to 169.8 ± 4.9 nm. The CANE induced reactive oxygen species (ROS) production in A549 cells, leading to activation of key regulators of apoptosis such as p-JNK, Bax and Bcl2 as well as release of cytochrome C, and activation of the caspase cascade. Suppression of mitochondrial ROS using Mito-TEMPO reversed the apoptotic potential of CANE signifying involvement of mitochondrial ROS in cell death. Beside, CANE displayed a strong antitumor potential in vivo using an athymic nude mice model. The results strongly support that CANE induced apoptosis in A549 cells by induction of ROS and could be a promising candidate for lung cancer therapy.
Influences of mesoporous magnesium calcium silicate on mineralization, degradability, cell responses, curcumin release from macro-mesoporous scaffolds of gliadin based biocomposites
Authors: Wang Sicheng , Gu Zhengrong , Wang Zhiwei , Chen Xiao , Cao Liehu , Cai Liang , Li Quan , Wei Jie , Shin Jung-Woog , Su Jiacan 
Published: January 2018

AbstractMacro-mesoporous scaffolds based on wheat gliadin (WG)/mesoporous magnesium calcium silicate (m-MCS) biocomposites (WMC) were developed for bone tissue regeneration. The increasing amount of m-MCS significantly improved the mesoporosity and water absorption of WMC scaffolds while slightly decreased their compressive strength. With the increase of m-MCS content, the degradability of WMC scaffolds was obviously enhanced, and the decrease of pH value could be slow down after soaking in Tris-HCl solution for different time. Moreover, the apatite mineralization ability of the WMC scaffolds in simulated body fluid (SBF) was obviously improved with the increase of m-MCS content, indicating good bioactivity. The macro-mesoporous WMC scaffolds containing m-MCS significantly stimulated attachment, proliferation and differentiation of MC3T3-E1 cells, indicating cytocompatibility. The WMC scaffold containing 40 w% m-MCS (WMC40) possessed the highest porosity (including macroporosity and mesoporosity), which loaded the highest amount of curcumin (CU) as well as displayed the slow release of CU. The results suggested that the incorporation of m-MCS into WG produced biocomposite scaffolds with macro-mesoporosity, which significantly improved water absorption, degradability, bioactivity, cells responses and load/sustained release of curcumin.
Refractive error is associated with intracranial volume
Authors: Takeuchi Hikaru , Taki Yasuyuki , Nouchi Rui , Yokoyama Ryoichi , Kotozaki Yuka , Nakagawa Seishu , Sekiguchi Atsushi , Iizuka Kunio , Yamamoto Yuki , Hanawa Sugiko , Araki Tsuyoshi , Miyauchi Carlos Makoto , Shinada Takamitsu , Sakaki Kohei , Sassa Yuko , Nozawa Takayuki , Ikeda Shigeyuki , Yokota Susumu , Daniele Magistro , Kawashima Ryuta 
Published: January 2018

AbstractMyopia is part of the spectrum of refractive error. Myopia is associated with psychometric intelligence and, the link between brain anatomy and myopia has been hypothesized. Here we aimed to identify the associations between brain structures and refractive error in developed young adults. In a study cohort of 1,319 normal educated young adults, the refractive error showed a significant negative correlation with total intracranial volume and total cerebrospinal fluid (CSF) volume but not with total gray matter volume (GMV) or total white matter volume (WMV). Time spent studying was associated with refractive error but could not explain the aforementioned associations with brain volume parameters. The R2 values of the simple regression between spherical equivalent and outcome variables for each sex in non-whole brain imaging analyses were less than 0.05 in all cases and thus were weak. Psychometric intelligence was not associated with refractive error or total CSF volume, but it weakly positively correlated with total GMV and total WMV in this study population. Thus, refractive error appears to be primarily (weakly) associated with the volume of the cranium, whereas psychometric intelligence was associated with the volume of the brain.
Poly(butylene succinate-co-terephthalate) nanofibrous membrane composited with cyclodextrin polymer for superhydrophilic property
Authors: Wei Zhenzhen , Pan Zhijuan , Li Faxue , Yu Jianyong 
Published: January 2018

We present a facile fabrication method for a PBST composite nanofibrous membrane with cyclodextrin polymer via electrospinning and heating processes. The membrane is superhydrophilic and water can completely spread on the surface within just 0.2 s.
Power optimisation of both a high‐speed counter and a retiming element for 2.4 GHz digital PLLs
Authors: Silva‐Pereira M. , Caldinhas Vaz J. 
Published: January 2018

The power optimisation at circuit level of a high‐speed counter and a retiming circuit aimed for ultra‐low‐power digital phase‐locked‐loops (PLLs) is presented. The high‐speed counter topology is based on a well‐known asynchronous type with a precise sampling phase generator. Different types of custom true single‐phase clock (TSPC) logic style are briefly revised and then strategically used. It is shown that a particular TSPC flip‐flop when operating as a retiming element can achieve optimal power efficiency. A prototype was fabricated in an earlier generation 0.13 μm CMOS technology and characterised with a 1 V supply. Measurements show a state‐of‐the‐art power consumption of about 48 μW when operating with a 2.4 GHz input signal.
Preparation of ZnS by magnetron sputtering and its buffer effect on the preferential orientation growth of ITO thin film
Authors: Du Wenhan , Yang Jingjing , Zhao Yu , Xiong Chao 
Published: January 2018

Two different deposition sequences were carried to investigate ZnS and indium‐tin oxide (ITO) multiple thin films on quartz substrates using magnetron sputtering technique. In the deposition order of ITO on ZnS layer, ZnS acts as a buffer layer with a thickness of at least 10 nm, and ITO thin film has (222) preferential orientation growth. Besides, lattice constant expansion phenomenon was observed when the film thickness of ITO was increased, indicating tension stress increase in ITO film. The lattice constant mismatch of 5% is the reason for the preferential orientation growth between ZnS and ITO thin films. In the other deposition sequence of ZnS on ITO layer, ZnS thin film has (111) preferential orientation growth. While ITO was kept in multiple crystalline properties. Pinhole‐free ZnS thin film was observed by scanning electron microscopy for this deposition sequential, promising well interface in the thin film solar cells with lower interface defects.
The formation of urea in space
Authors: Brigiano Flavio Siro , Jeanvoine Yannick , Largo Antonio , Spezia Riccardo 
Published: January 2018

Context.Many organic molecules have been observed in the interstellar medium thanks to advances in radioastronomy, and very recently the presence of urea was also suggested. While those molecules were observed, it is not clear what the mechanisms responsible to their formation are. In fact, if gas-phase reactions are responsible, they should occur through barrierless mechanisms (or with very low barriers). In the past, mechanisms for the formation of different organic molecules were studied, providing only in a few cases energetic conditions favorable to a synthesis at very low temperature. A particularly intriguing class of such molecules are those containing one N–C–O peptide bond, which could be a building block for the formation of biological molecules. Urea is a particular case because two nitrogen atoms are linked to the C–O moiety. Thus, motivated also by the recent tentative observation of urea, we have considered the synthetic pathways responsible to its formation.Aims.We have studied the possibility of forming urea in the gas phase via different kinds of bi-molecular reactions: ion-molecule, neutral, and radical. In particular we have focused on the activation energy of these reactions in order to find possible reactants that could be responsible for to barrierless (or very low energy) pathways.Methods.We have used very accurate, highly correlated quantum chemistry calculations to locate and characterize the reaction pathways in terms of minima and transition states connecting reactants to products.Results.Most of the reactions considered have an activation energy that is too high; but the ion-molecule reaction between NH2OHNH2OH2+and formamide is not too high. These reactants could be responsible not only for the formation of urea but also of isocyanic acid, which is an organic molecule also observed in the interstellar medium.
The GALEX Ultraviolet Virgo Cluster Survey (GUViCS)
Authors: Boissier S. , Cucciati O. , Boselli A. , Mei S. , Ferrarese L. 
Published: January 2018

Context. At low redshift, early-type galaxies often exhibit a rising flux with decreasing wavelength in the 1000–2500 Å range, called “UV upturn”. The origin of this phenomenon is debated, and its evolution with redshift is poorly constrained. The observed GALEX FUV-NUV color can be used to probe the UV upturn approximately to redshift 0.5.Aim. We provide constraints on the existence of the UV upturn up to redshift ~0.4 in the brightest cluster galaxies (BCG) located behind the Virgo cluster, using data from the GUViCS survey.Methods. We estimate the GALEX far-UV (FUV) and near-UV (NUV) observed magnitudes for BCGs from the maxBCG catalog in the GUViCS fields. We increase the number of nonlocal galaxies identified as BCGs with GALEX photometry from a few tens of galaxies to 166 (64 when restricting this sample to relatively small error bars). We also estimate a central color within a 20 arcsec aperture. By using the r-band luminosity from the maxBCG catalog, we can separate blue FUV-NUV due to recent star formation and candidate upturn cases. We use Lick indices to verify their similarity to redshift 0 upturn cases.Results. We clearly detect a population of blue FUV-NUV BCGs in the redshift range 0.10–0.35, vastly improving the existing constraints at these epochs by increasing the number of galaxies studied, and by exploring a redshift range with no previous data (beyond 0.2), spanning one more Gyr in the past. These galaxies bring new constraints that can help distinguish between assumptions concerning the stellar populations causing the UV upturn phenomenon. The existence of a large number of UV upturns around redshift 0.25 favors the existence of a binary channel among the sources proposed in the literature.
Risk Factors for Contralateral ACL Injury: A Single Institution Case–Control Study
Authors: Pierce Todd , Issa Kimona , Cassidy Kaitlin , Festa Anthony , McInerney Vincent , Scillia Anthony 
Published: January 2018

AbstractOur purpose was to evaluate if there is any association between requiring contralateral anterior cruciate ligament (ACL) reconstruction and various: (1) demographics, (2) patient characteristics, and (3) surgery-specific factors. A prospectively collected database at a single institution was queried to find all patients who underwent primary ACL reconstruction between 2012 and 2014. We identified 312 primary ACL reconstruction patients with a mean age of 24 years and a mean follow-up of 3 years (range, 2–5 years). This cohort was compared with all those who had primary ACL reconstructions during the same time period without a contralateral procedure. We evaluated: (1) incidence, (2) demographic variables, (3) family history, (4) graft choice, (5) activity causing injury, and (6) mechanism of injury (contact versus noncontact). There were 16 patients (4.8%) with a mean age of 21 years and a mean follow-up of 3 years that required a contralateral reconstruction. More females required contralateral reconstruction when compared with the control cohort (p = 0.049). However, there was no difference in the mean age between the cohorts (p = 0.32). Those who underwent reconstruction using a tibialis anterior allograft were far more likely to require a contralateral reconstruction (p = 0.0002). Bone-tendon-bone patellar autograft (p = 0.16), hamstring autograft (p = 0.76), and hamstring allograft (p = 0.68) had similar incidences of contralateral ACL injury. Lacrosse was associated with higher risk of contralateral procedure (p = 0.03). Mechanism of injury had no association of contralateral reconstruction (p = 0.71). We found that those with the highest risk of contralateral ACL reconstruction following their index procedure were females, those with tibialis anterior allografts, and those who had their ipsilateral injury while playing lacrosse. These data may be used by practitioners when educating patients regarding their potential for requiring a contralateral reconstruction following their index procedure.
Preterm Preeclampsia with Severe Features: Composite Maternal and Neonatal Morbidities Associated with Fetal Growth Restriction
Authors: Khanagura Raminder , Kregel Heather , Amro Farah , Sibai Baha , Chauhan Suneet , Balogun Olaide 
Published: January 2018

Objective The objective of this study was to compare adverse pregnancy outcomes between fetuses with estimated fetal weight (EFW) < 10 to > 10% in women with preterm preeclampsia (PE) with severe features.
Materials and Methods All women with preterm PE with severe features and nonanomalous singletons with EFW were identified at a tertiary center. Women with oligohydramnios or absent/reversed umbilical Doppler velocimetry were excluded. Using multivariable analysis, we compared the composite maternal and neonatal morbidities (CMM and CNM) between those with appropriate for gestational age (AGA) fetal growth, defined as EFW at 10 to 90th versus those with fetal growth restriction (FGR), defined as EFW < 10th percentile for gestational age (GA).
Results In this study, 165 patients were included; 112 had EFW at 10th to 90th percentile, and 53 had FGR. Of the 53 with FGR, 33 (62%) had EFW at 5 to 9% for GA and 20 (38%) had EFW < fifth percentile for GA. The CMM was significantly higher among women with FGR versus AGA (29 vs. 7%; p < 0.001). The CNM was significantly higher with FGR versus AGA (20 vs. 6%; p = 0.01).
Conclusion Women with preterm PE with severe features and FGR, when compared with those with AGA, have significantly higher risk of CMM and CNM.
Körperliche Aktivität im Kontext der betrieblichen Gesundheitsförderung – ein systematisches Review zur Effektivität software- gegenüber personalgestützter Interventionen
Authors: Rudolph Sabrina , Göring Arne , Padrok Dennis 
Published: January 2018

Zusammenfassung
Ziel der Studie Sport- und Bewegungsinterventionen erfahren im betrieblichen Kontext eine hohe Aufmerksamkeit. Aufgrund einer zunehmenden Digitalisierung finden insbesondere softwaregestützte Interventionen zur Bewegungsförderung immer häufiger den Weg in die Praxis. Empirische Nachweise hinsichtlich der Effektivität sind im betrieblichen Kontext bislang gering. Der Beitrag untersucht die Fragestellung, inwiefern softwaregestützte Interventionen eine höhere Effektivität als personalgestützte Interventionen hinsichtlich der Steigerung körperlicher Aktivität darstellen.
Methodik Es wurde ein systematischer Review nach den Vorgaben der Cochrane Collaboration durchgeführt. Dazu wurden Einschluss- und Sollkriterien festgelegt und mittels der Sollkriterien ein Qualitätsscore der Studien errechnet. In 2 Summary-of-findings-Tabellen werden die software- und personalgestützten Interventionen nach den Kategorien Autor, Jahr, Land, Stichprobe, Ziel der Intervention, Methodik, Outcome und Studienqualität präsentiert.
Ergebnisse Es wurden insgesamt 25 Studien in die Auswertung einbezogen (12 personal- und 13 softwaregestützte Interventionen). Der Qualitätsscore lag zwischen 3 und 9 und die Ergebnisse sind insgesamt sehr heterogen. In jeweils 5 personal- als auch softwaregestützten Interventionen konnte eine Steigerung der körperlichen Aktivität erzielt werden. Weitere positive gesundheitliche Effekte zeigten sich z. B. in der Verringerung des Blutdrucks und des Body Mass Indexes. In wenigen Studien kam es zu keiner Verbesserung gesundheitsbezogener Parameter.
Schlussfolgerung Der vorliegende Beitrag zeigt auf, dass sich durch beide Interventionsformen positive Effekte generieren lassen. Softwaregestützte Interventionen weisen Vorteile durch den Einsatz neuer Technologien auf. Durch die Verwendung von z. B. Desktop- und App-Anwendungen werden die Organisation, Kommunikation und Datenerfassung erleichtert und es werden weniger Ressourcen in der Durchführung benötigt. Der Einsatz eines geschulten Trainers hat dahingegen den Vorteil, dass dieser auf die spezifischen, variierenden Bedürfnisse der Mitarbeiter eingehen kann. Dieser Aspekt sollte als besonders bedeutsam bewertet werden.
Changes to the Editorial Team of the IJSM
Authors: Duarte José 
Published: January 2018

There have been some changes to the Board of Editors of the IJSM. Already this year, Prof. Donald Dengel of the University of Minnesota, USA, replaced editor Prof. Joseph Houmard, who had been with the journal since 2006 and chose to leave the team for professional reasons.Unfortunately, our Editor-in-Chief Prof. Appell Coriolano is fast approaching his retirement from academia and will also be leaving the IJSM editorial team. Hans-Joachim Appell Coriolano joined the Editorial Board of the IJSM in 1987 and accepted the position of Assistant Editor in 1989. Over the years, he gradually assumed even greater responsibility for manuscript organization and editing. He has served as Editor-in-Chief since 2006 and is regarded as a true “primus inter pares” within the editors' team. For his tremendous commitment and unwavering dedication to the IJSM for nearly 30 years, Prof. Appell Coriolano is acknowledged by his peers and Thieme Publishers as the “heart and soul” of the IJSM as it exists today. The level of scientific quality and international recognition attained by the IJSM is in large part due to his valuable contributions and scientific rigor. It is therefore with great regret that we bid him farewell, but we are sure that his guidance and spirit will continue to shape the future of this publication.
Amelioration of diabetic nephropathy by oral administration of d-α-tocopherol and its mechanisms
Authors: Hayashi Daiki , Ueda Shuji , Yamanoue Minoru , Ashida Hitoshi , Shirai Yasuhito 
Published: January 2018

AbstractDiabetic nephropathy (DN) is a diabetic vascular complication, and abnormal protein kinase C (PKC) activation from increased diacylglycerol (DG) production in diabetic hyperglycemia is one of the causes of DN. Diacylglycerol kinase (DGK) converts DG into phosphatidic acid. In other words, DGK can attenuate PKC activity by reducing the amount of DG. Recently, we reported that intraperitoneally administered d-α-tocopherol (vitamin E, αToc) induces an amelioration of DN in vivo through the activation of DGKα and the prevention of podocyte loss. However, the effect of the oral administration of αToc on DN in mice remains unknown. Here, we evaluated the effect of oral administration of αToc on DN and its molecular mechanism using streptozocin-induced diabetic mice. Consequently, the oral administration of αToc significantly ameliorated the symptoms of DN by preventing the loss of podocytes, and it was revealed that the inhibition of PKC activity was involved in this amelioration.
The Prandtl–Tomlinson model of friction with stochastic driving
Authors: Jagla E A 
Published: January 2018

Abstract
We consider the classical Prandtl–Tomlinson model of a particle moving on a corrugated potential, pulled by a spring. In the usual situation in which pulling acts at constant velocity

γ
˙

, the model displays an average friction force σ that relates to

γ
˙

(for small

γ
˙

)

as

γ
˙

∼
(
σ
−

σ

c

)

β

, where

σ

c

is a critical friction force. The possible values of β are well known in terms of the analytical properties of the corrugated potential. We study here the situation in which the pulling has, in addition to the constant velocity term, a stochastic term of mechanical origin. We analytically show how this term modifies the force-velocity dependence close to the critical force, and give the value of β in terms of the analytical properties of the corrugation potential and the scaling properties of the stochastic driving, encoded in the value of its Hurst exponent.
Recognition Memory Dysfunction Relates to Hippocampal Subfield Volume: A Study of Cognitively Normal and Mildly Impaired Older Adults
Authors: Bennett Ilana J , Stark Shauna M , Stark Craig E L 
Published: January 2018

AbstractObjectivesThe current study examined recognition memory dysfunction and its neuroanatomical substrates in cognitively normal older adults and those diagnosed with mild cognitive impairment (MCI).MethodsParticipants completed the Mnemonic Similarity Task, which provides simultaneous measures of recognition memory and mnemonic discrimination. They also underwent structural neuroimaging to assess volume of medial temporal cortex and hippocampal subfields.ResultsAs expected, individuals diagnosed with MCI had significantly worse recognition memory performance and reduced volume across medial temporal cortex and hippocampal subfields relative to cognitively normal older adults. After controlling for diagnostic group differences, however, recognition memory was significantly related to whole hippocampus volume, and to volume of the dentate gyrus/CA3 subfield in particular. Recognition memory was also related to mnemonic discrimination, a fundamental component of episodic memory that has previously been linked to dentate gyrus/CA3 structure and function.DiscussionResults reveal that hippocampal subfield volume is sensitive to individual differences in recognition memory in older adults independent of clinical diagnosis. This supports the notion that episodic memory declines along a continuum within this age group, not just between diagnostic groups.