bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report of myometrial window following fetoscopic treatment of twin‐twin transfusion syndrome: indications of underlying collagen vascular disease?
Authors: Zaretsky Michael V. , Manchester David K. , Galan Henry L. , Behrendt Nicholas J. , Marwan Ahmed I. , Liechty Kenneth W. , Crombleholme Timothy M. 
Published: May 2017

Key Clinical MessageIntraperitoneal amniotic fluid leak is a known complication of fetoscopic procedures that usually resolves spontaneously with expectant management. Intraperitoneal amniotic fluid leak may persist after fetoscopic procedures due to a myometrial window as well as to persistent chorioamniotic membrane disruption, which may be amenable to surgical repair.
Identification of EPCAM mutation: clinical use of microarray
Authors: Tan Queenie K.‐G. , Cardona Diana M. , Rehder Catherine W. , McDonald Marie T. 
Published: May 2017

Key Clinical MessageWe report a case of an infant with congenital tufting enteropathy (CTE) who presented with severe failure to thrive despite multiple interventions. This study illustrates that CTE may be missed by endoscopy, and the use of chromosomal microarray and immunohistological analysis may be integral to diagnosis.
Prenatal identification of two discontinuous maternally inherited chromosome 7q36.3 microduplications totaling 507 kb including the sonic hedgehog gene in a fetus with multiple congenital anomalies
Authors: Micale Mark , Embrey Bedford , Hubbell Katie , Beaudry‐Rogers Kelly , Whitten Amy 
Published: May 2017

Key Clinical MessageDuplications of the SHH gene, an important developmental gene, are rare. Disruption of this gene produces a variable phenotype in humans from major anomalies to isolated facial defects. This is the first reported case of a maternally inherited 507 kb discontinuous chromosome 7q36.3 microduplication resulting in duplication of SHH and nearby enhancer sequences.
Colchicine reduced pericardial effusion due to postcardiac injury syndrome following cardiac resynchronization therapy implantation
Authors: Hoshiyama Tadashi , Ashikaga Keiichi , Tsujita Kenichi , Shibata Yoshisato 
Published: May 2017

Key Clinical MessageWe present a case of postcardiac injury syndrome with pericardial effusion following cardiac resynchronization therapy implantation which was treated by only colchicine. Although treatment using colchicine is not as common as NSAIDs or steroids, colchicine seems to be an effective and safe treatment option for the syndrome.
Metastatic pulmonary artery sarcoma presented with tamponade: a case report
Authors: Hajsadeghi Shokoufeh , Kooranifar Siavash , Ansarinejad Nafise , Sadeghipour Alireza , Iranpour Aida , Aziz Ahari Alireza 
Published: May 2017

Key Clinical MessagePulmonary artery sarcoma is a rare tumor with varying presentations including pericardial effusion and pulmonary metastasis. Single‐nucleotide polymorphism array is a novel method that can be used to define tumor genome and be used as a guidance to choose the proper treatment regimen.
A pH‐Responsive DNAsome from the Self‐Assembly of DNA–Phenyleneethynylene Hybrid Amphiphile
Authors: Albert Shine K. , Golla Murali , Thelu Hari Veera Prasad , Krishnan Nithiyanandan , Varghese Reji 
Published: May 2017

AbstractA pH‐responsive DNAsome derived from the amphiphilicity‐driven self‐assembly of DNA amphiphile containing C‐rich DNA sequence is reported. The acidification of DNAsome induces a structural change of C‐rich DNA from random coil to an i‐motif structure that triggers the disassembly of DNAsome and its subsequent morphological transformation into an open entangled network. The encapsulation of a hydrophobic guest into the membrane of DNAsome and its pH‐triggered release upon acidification of DNAsome is also demonstrated.
Organocatalytic Stereoconvergent Synthesis of α‐CF3 Amides: Triketopiperazines and Their Heterocyclic Metamorphosis
Authors: Foster Robert W. , Lenz Eva N. , Simpkins Nigel S. , Stead Darren 
Published: May 2017

AbstractThe highly enantioselective alkylation of α‐CF3 enolates, generated from triketopiperazines, has been accomplished through use of a bifunctional thiourea organocatalyst to facilitate 1,4‐addition to varied enone acceptors. On treatment with appropriate nitrogen nucleophiles, the chiral triketopiperazine products undergo a metamorphosis, to provide novel fused heterocyclic lactams such as extended pyrazolopyrimidines.
Bimetallic Cooperativity in Proton Reduction with an Amido‐Bridged Cobalt Catalyst
Authors: Kpogo Kenneth K. , Mazumder Shivnath , Wang Denan , Schlegel H. Bernhard , Fiedler Adam T. , Verani Cláudio N. 
Published: May 2017

AbstractThe bimetallic catalyst [CoII2(L1)(bpy)2]ClO4 (1), in which L1 is an [NN′2O2] fused ligand, efficiently reduced H+ to H2 in CH3CN in the presence of 100 equiv of HOAc with a turnover number of 18 and a Faradaic efficiency of 94 % after 3 h of bulk electrolysis at −1.6 V (vs. Ag/AgCl). This observation allowed the proposal that this bimetallic cooperativity is associated with distance, angle, and orbital alignment of the two Co centers, as promoted by the unique Co−Namido−Co environment offered by L1. Experimental results revealed that the parent [CoIICoII] complex undergoes two successive metal‐based 1 e− reductions to generate the catalytically active species [CoICoI], and DFT calculations suggested that addition of a proton to one CoI triggers a cooperative 1 e− transfer by each of these CoI centers. This 2 e− transfer is an alternative route to generate a more reactive [CoII(CoII−H−)] hydride, thus avoiding the CoIII−H− required in monometallic species. This [CoII(CoII−H−)] species then accepts another H+ to release H2.
Outcomes for patients with locally advanced pancreatic adenocarcinoma treated with stereotactic body radiation therapy versus conventionally fractionated radiation
Authors: Zhong Jim , Patel Kirtesh , Switchenko Jeffrey , Cassidy Richard J. , Hall William A. , Gillespie Theresa , Patel Pretesh R. , Kooby David , Landry Jerome 
Published: May 2017

BACKGROUNDAs systemic therapy has improved for locally advanced pancreatic cancer (LAPC), efforts to improve local control with optimal radiotherapy may be critical. Although conventionally fractionated radiation therapy (CFRT) has more recently shown a limited role in LAPC, stereotactic body radiation therapy (SBRT) is an emerging approach with promising results. With no studies to date comparing SBRT with CFRT for LAPC, this study used the National Cancer Data Base (NCDB) to evaluate these 2 modalities.METHODSWith the NCDB, patients with American Joint Committee on Cancer cT2‐4/N0‐1/M0 adenocarcinoma of the pancreas diagnosed from 2004 to 2013 were analyzed. Radiation therapy delivered at ≤2 Gy was deemed CFRT, and radiation therapy delivered at ≥4 Gy per fraction was considered SBRT. Kaplan‐Meier analysis, log‐rank testing, and multivariate Cox proportional hazards regression were performed with overall survival (OS) as the primary outcome. Propensity score matching was used.RESULTSAmong 8450 patients, 7819 (92.5%) were treated with CFRT, and 631 (7.5%) underwent SBRT. Receipt of SBRT was associated with superior OS in the multivariate analysis (hazard ratio, 0.84; 95% confidence interval, 0.75‐0.93; P < .001). With propensity score matching, 988 patients in all were matched, with 494 patients in each cohort. Within the propensity‐matched cohorts, the median OS (13.9 vs 11.6 months) and the 2‐year OS rate (21.7% vs 16.5%) were significantly higher with SBRT versus CFRT (P = .0014).CONCLUSIONSIn this retrospective review using a large national database, SBRT was associated with superior OS in comparison with CFRT for LAPC, and these findings remained significant in a propensity‐matched analysis. Further prospective studies investigating these hypothesis‐generating results are warranted. Cancer 2017;123:3486‐93. © 2017 American Cancer Society.
Hepatitis B virus screening and reactivation and management of patients with nasopharyngeal carcinoma: A large‐scale, big‐data intelligence platform–based analysis from an endemic area
Authors: Lv Jia‐Wei , Chen Yu‐Pei , Huang Xiao‐Dan , Zhou Guan‐Qun , Chen Lei , Li Wen‐Fei , Tang Ling‐Long , Mao Yan‐Ping , Guo Ying , Xu Rui‐Hua , Ma Jun , Sun Ying 
Published: May 2017

BACKGROUNDChemotherapy, target therapy, and immunotherapy are increasingly being used in the systematic treatment of nasopharyngeal carcinoma (NPC), during which the occurrence of hepatitis B virus (HBV) reactivation might increase. However, data regarding HBV screening and reactivation and the clinical management of NPC patients with HBV infections are lacking. This study was aimed at clarifying the risk of reactivation for NPC patients on different regimens while providing evidence concerning HBV screening and management in an endemic area.METHODSWith the NPC database from an established big‐data intelligence platform at Sun Yat‐Sen University Cancer Center in China, NPC patients who were diagnosed between 2008 and 2016 and underwent HBV screening and regular monitoring of liver enzymes and HBV deoxyribonucleic acid (DNA) were analyzed.RESULTSAmong the 46,919 patients identified, the HBV screening rate was 24.8% (11,616 of 46,919). Among the screened patients with an HBV infection, regular monitoring of liver enzymes and HBV DNA occurred for 563 patients. The incidence of HBV reactivation and HBV‐related hepatitis was 9.1% (51 of 563) and 2.5% (14 of 563), respectively. The reactivation risk varied for different treatments and regimens and ranged from 0.0% to 21.4%. Detectable baseline HBV DNA (odds ratio [OR], 2.93; P < .01), the presence of liver metastasis at diagnosis (OR, 7.19; P < .01), and antiviral prophylaxis (OR, 0.29; P < .01) were significantly associated with reactivation.CONCLUSIONSIn NPC patients with chronic HBV infections on high‐risk regimens, the reactivation risk is similar to or exceeds the risk associated with other immunosuppressive therapies for which screening and prophylaxis are recommended. Our findings, therefore, support HBV screening and prophylaxis for these patients, whereas regular monitoring might be appropriate for patients with resolved HBV infections or those receiving low‐risk regimens. Cancer 2017;123:3540‐9. © 2017 American Cancer Society.
Integrated Computational Protocol for the Analysis of Quadrupolar Splittings from Natural‐Abundance Deuterium NMR Spectra in (Chiral) Oriented Media
Authors: Navarro‐Vázquez Armando , Berdagué Philippe , Lesot Philippe 
Published: May 2017

AbstractThe front cover artwork is provided by Dr. Armando Navarro‐Vázquez from the department of fundamental chemistry of the Universidade Federal de Pernambuco (Brazil) as well as Dr. Philippe Berdagué and Dr. Philippe Lesot (DR CNRS), both from the Institut de Chimie Moléculaire et des Matériaux d'Orsay of the Université de Paris‐Sud/Paris‐Saclay (France). Graphically inspired by the famous word game «Scrabble», the image illustrates, through selected keywords, the analytical potential of a hyphenated computational protocol for investigating (achiral, prochiral or chiral) organic molecules by combining deuterium NMR spectroscopy at natural abundance level and chiral oriented systems, as described in their article. Read the full text of the article at 10.1002/cphc.201601423.
Attribute‐based online/offline signcryption scheme
Authors: Rao Y. Sreenivasa 
Published: May 2017

SummaryThe efficiency of computation is one of the prime concerns in public key cryptography. The notion of online/offline framework speeds up the process of encryption and signing. In this paper, we propose the firstattribute‐based online/offline signcryption scheme that is able to provide fine‐grained data access control with confidentiality, authenticity, signer anonymity, and public verifiability. The scheme supports large attribute universe and monotone Boolean function predicates. The size of the system public parameters in our scheme is constant, and the selective security of the scheme is realized in random oracle model. Note that, to the best of our knowledge, there is no normal attribute‐based signcryption scheme satisfying all the aforementioned functionality.
Mild, moderate, meaningful? Examining the psychological and functioning correlates of DSM‐5 eating disorder severity specifiers
Authors: Gianini Loren , Roberto Christina A. , Attia Evelyn , Walsh B. Timothy , Thomas Jennifer J. , Eddy Kamryn T. , Grilo Carlos M. , Weigel Thomas , Sysko Robyn 
Published: May 2017

AbstractObjectiveThis study evaluated the DSM‐5 severity specifiers for treatment‐seeking groups of participants with anorexia nervosa (AN), the purging form of bulimia nervosa (BN), and binge‐eating disorder (BED).MethodHundred and sixty‐two participants with AN, 93 participants with BN, and 343 participants with BED were diagnosed using semi‐structured interviews, sub‐categorized using DSM‐5 severity specifiers and compared on demographic and cross‐sectional clinical measures.ResultsIn AN, the number of previous hospitalizations and the duration of illness increased with severity, but there was no difference across severity groups on measures of eating pathology, depression, or measures of self‐reported physical or emotional functioning. In BN, the level of eating concerns increased across the severity groups, but the groups did not differ on measures of depression, self‐esteem, and most eating pathology variables. In BN, support was also found for an alternative severity classification scheme based upon number of methods of purging. In BED, levels of several measures of eating pathology and self‐reported physical and emotional functioning increased across the severity groups. For BED, however, support was also found for an alternative severity classification scheme based upon overvaluation of shape and weight. Preliminary evidence was also found for a transdiagnostic severity index based upon overvaluation of shape and weight.DiscussionOverall, these data show limited support for the DSM‐5 severity specifiers for BN and modest support for the DSM‐5 severity specifiers for AN and BED.
Historical demography and genetic differentiation of the giant freshwater prawn Macrobrachium rosenbergii in Bangladesh based on mitochondrial and ddRAD sequence variation
Authors: Alam M. M. Mahbub , Westfall Kristen M. , Pálsson Snæbjörn 
Published: May 2017

AbstractMacrobrachium rosenbergii, the giant freshwater prawn, is an important source of high quality protein and occurs naturally in rivers as well as commercial farms in South and South‐East Asia, including Bangladesh. This study investigated the genetic variation and population structure of M. rosenbergii sampled from four rivers in Bangladesh (sample size ranged from 19 to 20), assessing sequence variation, both in the mitochondrial cytochrome oxidase subunit 1 (CO1) gene and in 106 single nucleotide polymorphisms (SNPs) sampled randomly from the genome with double digest RAD sequencing (ddRADseq). The mitochondrial variation presented a shallow genealogy with high haplotype diversity (h = 0.95), reflecting an expansion in population size for the last ~82 kyr. Based on the CO1 variation the current effective population size (Ne) was 9.7 × 106 (CI: 1.33 × 106 – 35.84 × 106) individuals. A significant population differentiation was observed with the mitochondrial CO1 sequence variation and based on the ddRADseq variation, which could be traced to the divergence of the population in the Naf River in the South‐East border with Myanmar from the other populations. A differentiation in mtDNA haplotype frequencies was also observed between the Biskhali River and the Karnaphuli Rivers in eastern Bangladesh. This study demonstrated the use of high‐throughput genotyping based on the ddRADseq method to reveal population structure at a small geographical scale for an important freshwater prawn. The information from this study can be utilized for management and conservation of this species in Bangladesh.
Microwave‐Assisted Hydrothermal Synthesis of CuO–ZnO–ZrO2 as Catalyst for Direct Synthesis of Methanol by Carbon Dioxide Hydrogenation
Authors: Huang Chong , Mao Dongsen , Guo Xiaoming , Yu Jun 
Published: May 2017

AbstractA series of CuO–ZnO–ZrO2 catalysts was prepared by a facile microwave‐assisted hydrothermal synthesis method and used for the direct synthesis of methanol by CO2 hydrogenation in a fixed‐bed reactor at 240 °C, 3.0 MPa, CO2/H2=1:3 (v/v), and space velocity of 2400 mL gcat−1 h−1. The effects of the hydrothermal synthesis temperature (80–150 °C) on the physicochemical properties and catalytic activity of the CuO–ZnO–ZrO2 catalysts were investigated by using several techniques, including XRD, N2 adsorption, reactive N2O adsorption, SEM with energy‐dispersive X‐ray spectroscopy, X‐ray photoelectron spectroscopy, temperature‐programmed reduction by H2, and the temperature‐programmed desorption of adsorbed CO2 and H2. The catalyst prepared at 120 °C possessed a high surface area, a high dispersion of Cu species, a high adsorption capacity for CO2 and H2, and thus exhibited a high CO2 conversion and methanol selectivity. The surface area of metallic Cu (SCu) is the critical factor in determining the activity of the CuO–ZnO–ZrO2 catalyst.
A distributed learning–based user association for heterogeneous networks
Authors: Hajijamali Arani Atefeh , Omidi Mohammad Javad , Mehbodniya Abolfazl , Adachi Fumiyuki 
Published: May 2017

AbstractThe coexistence of various base stations (BSs) in heterogeneous networks (HetNets) has emerged as a promising approach to meet the ever increasing network capacity. In these networks, one of the important issues is the problem of associating user equipments (UEs) to BSs. In this paper, we investigate the UE association (UEA) problem in heterogeneous networks and propose a load‐aware UEA mechanism based on the BSs' estimated load and signal‐to‐interference‐and‐noise ratio. The proposed mechanism can capture the trade‐off between UE's quality‐of‐service requirement and delay. We model this strategic UE‐BS association as a noncooperative game. To solve the game, we develop a fully distributed algorithm inspired by machine learning techniques, whereby the proposed UEA scheme corresponds to a Markov chain. In the proposed scheme, each UE senses its environment and decides which BS to select based on the satisfaction technique. Therefore, it achieves a high level of satisfaction for UEs. Furthermore, use of historical information helps UEs select BSs with better long‐term performance. Simulation results show that the proposed mechanism reduces fractional transfer time and the number of unsatisfied UEs, respectively, up to about 46% and 52.3% and improves BS throughput up to about 15.4% compared to a benchmark algorithm that is based on the received signal strength and the BS's estimated load.
Flow resistance equation for rills
Authors: Di Stefano Costanza , Ferro Vito , Palmeri Vincenzo , Pampalone Vincenzo 
Published: May 2017

AbstractIn this paper, a new flow resistance equation for rill flow was deduced applying dimensional analysis and self‐similarity theory. At first, the incomplete self‐similarity hypothesis was used for establishing the flow velocity distribution whose integration gives the theoretical expression of the Darcy–Weisbach friction factor. Then the deduced theoretical resistance equation was tested by some measurements of flow velocity, water depth, cross section area, wetted perimeter, and bed slope carried out in 106 reaches of some rills shaped on an experimental plot. A relationship between the velocity profile, the channel slope, and the flow Froude number was also established. The analysis showed that the Darcy–Weisbach friction factor can be accurately estimated by the proposed theoretical approach based on a power–velocity profile.
Dysregulated Metabolism of the Amyloid‐β Protein and Therapeutic Approaches in Alzheimer Disease
Authors: Kikuchi Kazunori , Kidana Kiwami , Tatebe Takuya , Tomita Taisuke 
Published: May 2017

ABSTRACTAmyloid‐β protein (Aβ) is the main component of senile plaques in the brains of Alzheimer disease (AD) patients. Aβ is proteolytically derived from amyloid‐β precursor protein by β‐ and γ‐secretases. Secreted Aβ is then eliminated from the central nervous system by multiple clearance mechanisms, including phagocytosis, immune responses, and proteolytic degradation. These dynamic metabolic processes, which are referred to as Aβ economy, regulate steady‐state brain Aβ levels. Familial AD‐linked genetic mutations augment the production and aggregation of Aβ. In contrast, rare genetic variants that reduce Aβ production were protective against AD. Moreover, decreased Aβ clearance has been demonstrated in sporadic AD patients, suggesting that dysregulation of Aβ economy contributes to the development of AD. Thus, several approaches to inhibit the production as well as to enhance the clearance of Aβ have been investigated as potential therapeutics against AD. In this manuscript, we introduce the molecules and cellular mechanisms involved in the regulation of Aβ economy and discuss the current understanding of these processes in the development of therapeutics against AD. J. Cell. Biochem. 118: 4183–4190, 2017. © 2017 Wiley Periodicals, Inc.
Isotropic three‐dimensional T2 mapping of knee cartilage: Development and validation
Authors: Colotti Roberto , Omoumi Patrick , Bonanno Gabriele , Ledoux Jean‐Baptiste , van Heeswijk Ruud B. 
Published: May 2017

Purpose1) To implement a higher‐resolution isotropic 3D T2 mapping technique that uses sequential T2‐prepared segmented gradient‐recalled echo (Iso3DGRE) images for knee cartilage evaluation, and 2) to validate it both in vitro and in vivo in healthy volunteers and patients with knee osteoarthritis.Materials and MethodsThe Iso3DGRE sequence with an isotropic 0.6 mm spatial resolution was developed on a clinical 3T MR scanner. Numerical simulations were performed to optimize the pulse sequence parameters. A phantom study was performed to validate the T2 estimation accuracy. The repeatability of the sequence was assessed in healthy volunteers (n = 7). T2 values were compared with those from a clinical standard 2D multislice multiecho (MSME) T2 mapping sequence in knees of healthy volunteers (n = 13) and in patients with knee osteoarthritis (OA, n = 5).ResultsThe numerical simulations resulted in 100 excitations per segment and an optimal radiofrequency (RF) excitation angle of 15°. The phantom study demonstrated a good correlation of the technique with the reference standard (slope 0.9 ± 0.05, intercept 0.2 ± 1.7 msec, R2 ≥ 0.99). Repeated measurements of cartilage T2 values in healthy volunteers showed a coefficient of variation of 5.6%. Both Iso3DGRE and MSME techniques found significantly higher cartilage T2 values (P < 0.03) in OA patients. Iso3DGRE precision was equal to that of the MSME T2 mapping in healthy volunteers, and significantly higher in OA (P = 0.01).ConclusionThis study successfully demonstrated that high‐resolution isotropic 3D T2 mapping for knee cartilage characterization is feasible, accurate, repeatable, and precise. The technique allows for multiplanar reformatting and thus T2 quantification in any plane of interest.Level of Evidence: 1Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2018;47:362–371.