bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technological Capability, Marketing Capability, and Firm Performance in Turbulent Conditions
Authors: Su Zhongfeng , Peng Jisheng , Shen Hao , Xiao Ting 
Published: August 2016

AbstractThe manner in which technological capability and marketing capability can be successfully leveraged is an important research issue. Based on the resource-management model, this study aims to answer two research questions: (1) whether technological capability and marketing capability are complementary or supplementary capabilities; and (2) how technological capability and marketing capability can be used appropriately to respond to environmental turbulence. Based on a face-to-face interview survey of 212 Chinese firms, we find that technological capability and marketing capability have synergistic effects. We also find that technological turbulence enhances the performance effect of technological capability, but impedes that of marketing capability; whereas market turbulence advances the performance effect of marketing capability, but impedes that of technological capability. Thus, the appropriate way to leverage technological capability and marketing capability is to integrate them and to deploy technological capability to respond to technological turbulence and marketing capability to respond to market turbulence.
Leader–Member Relationship and Burnout: The Moderating Role of Leader Integrity
Authors: Jiang Jane Y. ,   罗胜强,   孙健敏
Published: August 2016

AbstractIn this study, we propose and test the idea that a strong relationship between leader and follower will be associated with the subordinate’s burnout. We base the study on the leader–member exchange framework (LMX), resource exchange theory, and the job demands–resources model of burnout, and conceptualize that a strong LMX is associated with burnout in two ways: high LMX involves high job demands, which lead to exhaustion; low LMX involves low job resources, which leads to cynicism. We propose that the relationship between LMX and the two forms of burnout will be stronger when the leader is perceived to be low on moral integrity. Using a survey of 218 employees, we find support for the hypotheses. Implications for future research and managerial practices are discussed.
Leader Integrity and Organizational Citizenship Behaviour in China
Authors:   张刚,   白云涛, Caza Arran ,   王璐
Published: August 2016

Abstract
In this study, we use implicit leadership theory to investigate how leader integrity, one of the most important traditional Chinese virtues, influences subordinates’ organizational citizenship behaviour (OCB) in the Chinese context. The results of our survey reveal that leader integrity is associated with subordinates’ OCB, and that this relationship is fully mediated by leader effectiveness. In addition, traditionality moderated the relationship between leader integrity and leader effectiveness; the relationship was significant among less traditional subordinates, but insignificant among more traditional subordinates. We conclude with a discussion of the theoretical and managerial implications for leaders in China.
Chinese Outward Foreign Direct Investment Performance: The Role of Learning
Authors: Lyles Marjorie , Li Dan , Yan Haifeng 
Published: August 2016

AbstractWe define the ‘Chinese way’ of internationalization as oriented toward experimental learning, in contrast to traditional internationalization models, such as the Uppsala model. Analyses of survey data of private Chinese firms that have made outward foreign direct investments (OFDI) show that only 50 percent follow the Uppsala model in which firms follow a staged approach. The other 50 percent follow more risky explorative OFDI approaches in which the firms learn on the ground experimentally from their OFDI. We further investigate how the founders’ congenital learning, firms’ inward international experience, potential absorptive capabilities, and motivations to learn, influence OFDI performance and how learning outcomes mediate these relationships. We show that the relationship between the firm’s potential absorptive capacity and its OFDI performance is fully mediated by what the firm learned from the OFDI project. Also the firm’s motivation to learn directly affects performance and is partially mediated by what the firm has learned.
WEAK DISHARMONY: SOME LESSONS FOR PROOF-THEORETIC SEMANTICS
Authors: DICHER BOGDAN 
Published: August 2016

AbstractA logical constant is weakly disharmonious if its elimination rules are weaker than its introduction rules. Substructural weak disharmony is the weak disharmony generated by structural restrictions on the eliminations. I argue that substructural weak disharmony is not a defect of the constants which exhibit it. To the extent that it is problematic, it calls into question the structural properties of the derivability relation. This prompts us to rethink the issue of controlling the structural properties of a logic by means of harmony. I argue that such a control is possible and desirable. Moreover, it is best achieved by global tests of harmony.
Iridium-based double perovskites for efficient water oxidation in acid media
Authors: Diaz-Morales Oscar , Raaijman Stefan , Kortlever Ruud , Kooyman Patricia J. , Wezendonk Tim , Gascon Jorge , Fu W. T. , Koper Marc T. M. 
Published: August 2016

AbstractThe development of active, cost-effective and stable oxygen-evolving catalysts is one of the major challenges for solar-to-fuel conversion towards sustainable energy generation. Iridium oxide exhibits the best available compromise between catalytic activity and stability in acid media, but it is prohibitively expensive for large-scale applications. Therefore, preparing oxygen-evolving catalysts with lower amounts of the scarce but active and stable iridium is an attractive avenue to overcome this economical constraint. Here we report on a class of oxygen-evolving catalysts based on iridium double perovskites which contain 32 wt% less iridium than IrO2 and yet exhibit a more than threefold higher activity in acid media. According to recently suggested benchmarking criteria, the iridium double perovskites are the most active catalysts for oxygen evolution in acid media reported until now, to the best of our knowledge, and exhibit similar stability to IrO2.
β-Catenin C-terminal signals suppress p53 and are essential for artery formation
Authors: Riascos-Bernal Dario F. , Chinnasamy Prameladevi , Cao Longyue , Dunaway Charlene M. , Valenta Tomas , Basler Konrad , Sibinga Nicholas E. S. 
Published: August 2016

AbstractIncreased activity of the tumour suppressor p53 is incompatible with embryogenesis, but how p53 is controlled is not fully understood. Differential requirements for p53 inhibitors Mdm2 and Mdm4 during development suggest that these control mechanisms are context-dependent. Artery formation requires investment of nascent endothelial tubes by smooth muscle cells (SMCs). Here, we find that embryos lacking SMC β-catenin suffer impaired arterial maturation and die by E12.5, with increased vascular wall p53 activity. β-Catenin-deficient SMCs show no change in p53 levels, but greater p53 acetylation and activity, plus impaired growth and survival. In vivo, SMC p53 inactivation suppresses phenotypes caused by loss of β-catenin. Mechanistically, β-catenin C-terminal interactions inhibit Creb-binding protein-dependent p53 acetylation and p53 transcriptional activity, and are required for artery formation. Thus in SMCs, the β-catenin C-terminus indirectly represses p53, and this function is essential for embryogenesis. These findings have implications for angiogenesis, tissue engineering and vascular disease.
Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
Authors: Brem Jürgen , Cain Ricky , Cahill Samuel , McDonough Michael A. , Clifton Ian J. , Jiménez-Castellanos Juan-Carlos , Avison Matthew B. , Spencer James , Fishwick Colin W. G. , Schofield Christopher J. 
Published: August 2016

Abstractβ-Lactamases enable resistance to almost all β-lactam antibiotics. Pioneering work revealed that acyclic boronic acids can act as ‘transition state analogue’ inhibitors of nucleophilic serine enzymes, including serine-β-lactamases. Here we report biochemical and biophysical analyses revealing that cyclic boronates potently inhibit both nucleophilic serine and zinc-dependent β-lactamases by a mechanism involving mimicking of the common tetrahedral intermediate. Cyclic boronates also potently inhibit the non-essential penicillin-binding protein PBP 5 by the same mechanism of action. The results open the way for development of dual action inhibitors effective against both serine- and metallo-β-lactamases, and which could also have antimicrobial activity through inhibition of PBPs.
Simplified three-dimensional tissue clearing and incorporation of colorimetric phenotyping
Authors: Sung Kevin , Ding Yichen , Ma Jianguo , Chen Harrison , Huang Vincent , Cheng Michelle , Yang Cindy F. , Kim Jocelyn T. , Eguchi Daniel , Di Carlo Dino , Hsiai Tzung K. , Nakano Atsushi , Kulkarni Rajan P. 
Published: August 2016

AbstractTissue clearing methods promise to provide exquisite three-dimensional imaging information; however, there is a need for simplified methods for lower resource settings and for non-fluorescence based phenotyping to enable light microscopic imaging modalities. Here we describe the simplified CLARITY method (SCM) for tissue clearing that preserves epitopes of interest. We imaged the resulting tissues using light sheet microscopy to generate rapid 3D reconstructions of entire tissues and organs. In addition, to enable clearing and 3D tissue imaging with light microscopy methods, we developed a colorimetric, non-fluorescent method for specifically labeling cleared tissues based on horseradish peroxidase conversion of diaminobenzidine to a colored insoluble product. The methods we describe here are portable and can be accomplished at low cost and can allow light microscopic imaging of cleared tissues, thus enabling tissue clearing and imaging in a wide variety of settings.
Isolation and evaluation of proteolytic actinomycete isolates as novel inducers of pearl millet downy mildew disease protection
Authors: Jogaiah Sudisha , Kurjogi Mahantesh , Govind Sharathchandra Ramasandra , Huntrike Shekar Shetty , Basappa Vedamurthy Ankala , Tran Lam-Son Phan 
Published: August 2016

AbstractNative endophytic actinomycetes isolated from pearl millet roots were examined for their efficacy to protect pearl millet against downy mildew. Nineteen of 39 isolates were found to be proteolytic, of which 7 strains could directly suppress the sporangium formation of Sclerospora graminicola, the pearl millet downy mildew pathogen. Thus, mycelial suspensions containing either spores or cell-free extract of these 7 isolates were used for seed-coating and -soaking treatments to test for their induction of downy mildew resistance. Results indicated that seed-coating overall provided better protection to downy mildew than seed-soaking. In both treatments, the tested isolates demonstrated differential abilities in downy mildew disease protection, with Streptomyces griseus SJ_UOM-07-09 and Streptosporangium roseum SJ_UOM-18-09 showing the highest protection rates. Additionally, the levels of disease protection conferred by the actinomycetes were just slightly lower than that of the systemic fungicide Apron, suggesting their effectiveness. Further studies revealed that the more rapid root colonization by SJ_UOM-18-09 resulted in faster and higher induced resistance in comparison with SJ_UOM-07-09 under greenhouse conditions, indicating that SJ_UOM-18-09 was superior than SJ_UOM-07-09 in inducing resistance. Results from this study provide comprehensive information on biocontrol functions of SJ_UOM- 18-09 with great potential to control downy mildew disease in pearl millet.
Deciphering Variability of PKD1 and PKD2 in an Italian Cohort of 643 Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Authors: Carrera Paola , Calzavara Silvia , Magistroni Riccardo , den Dunnen Johan T. , Rigo Francesca , Stenirri Stefania , Testa Francesca , Messa Piergiorgio , Cerutti Roberta , Scolari Francesco , Izzi Claudia , Edefonti Alberto , Negrisolo Susanna , Benetti Elisa , Alibrandi Maria Teresa Sciarrone , Manunta Paolo , Boletta Alessandra , Ferrari Maurizio 
Published: August 2016

AbstractAutosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary kidney disease. We analysed PKD1 and PKD2, in a large cohort of 440 unrelated Italian patients with ADPKD and 203 relatives by direct sequencing and MLPA. Molecular and detailed phenotypic data have been collected and submitted to the PKD1/PKD2 LOVD database. This is the first large retrospective study in Italian patients, describing 701 variants, 249 (35.5%) already associated with ADPKD and 452 (64.5%) novel. According to the criteria adopted, the overall detection rate was 80% (352/440). Novel variants with uncertain significance were found in 14% of patients. Among patients with pathogenic variants, in 301 (85.5%) the disease is associated with PKD1, 196 (55.7%) truncating, 81 (23%) non truncating, 24 (6.8%) IF indels, and in 51 (14.5%) with PKD2. Our results outline the high allelic heterogeneity of variants, complicated by the presence of variants of uncertain significance as well as of multiple variants in the same subject. Classification of novel variants may be particularly cumbersome having an important impact on the genetic counselling. Our study confirms the importance to improve the assessment of variant pathogenicity for ADPKD; to this point databasing of both clinical and molecular data is crucial.
The suppression of scale-free fMRI brain dynamics across three different sources of effort: aging, task novelty and task difficulty
Authors: Churchill Nathan W. , Spring Robyn , Grady Cheryl , Cimprich Bernadine , Askren Mary K. , Reuter-Lorenz Patricia A. , Jung Mi Sook , Peltier Scott , Strother Stephen C. , Berman Marc G. 
Published: August 2016

AbstractThere is growing evidence that fluctuations in brain activity may exhibit scale-free (“fractal”) dynamics. Scale-free signals follow a spectral-power curve of the form P(f ) ∝ f−β, where spectral power decreases in a power-law fashion with increasing frequency. In this study, we demonstrated that fractal scaling of BOLD fMRI signal is consistently suppressed for different sources of cognitive effort. Decreases in the Hurst exponent (H), which quantifies scale-free signal, was related to three different sources of cognitive effort/task engagement: 1) task difficulty, 2) task novelty, and 3) aging effects. These results were consistently observed across multiple datasets and task paradigms. We also demonstrated that estimates of H are robust across a range of time-window sizes. H was also compared to alternative metrics of BOLD variability (SDBOLD) and global connectivity (Gconn), with effort-related decreases in H producing similar decreases in SDBOLD and Gconn. These results indicate a potential global brain phenomenon that unites research from different fields and indicates that fractal scaling may be a highly sensitive metric for indexing cognitive effort/task engagement.
Efficient shortcuts to adiabatic passage for three-dimensional entanglement generation via transitionless quantum driving
Authors: He Shuang , Su Shi-Lei , Wang Dong-Yang , Sun Wen-Mei , Bai Cheng-Hua , Zhu Ai-Dong , Wang Hong-Fu , Zhang Shou 
Published: August 2016

AbstractWe propose an effective scheme of shortcuts to adiabaticity for generating a three-dimensional entanglement of two atoms trapped in a cavity using the transitionless quantum driving (TQD) approach. The key point of this approach is to construct an effective Hamiltonian that drives the dynamics of a system along instantaneous eigenstates of a reference Hamiltonian to reproduce the same final state as that of an adiabatic process within a much shorter time. In this paper, the shortcuts to adiabatic passage are constructed by introducing two auxiliary excited levels in each atom and applying extra cavity modes and classical fields to drive the relevant transitions. Thereby, the three-dimensional entanglement is obtained with a faster rate than that in the adiabatic passage. Moreover, the influences of atomic spontaneous emission and photon loss on the fidelity are discussed by numerical simulation. The results show that the speed of entanglement implementation is greatly improved by the use of adiabatic shortcuts and that this entanglement implementation is robust against decoherence. This will be beneficial to the preparation of high-dimensional entanglement in experiment and provides the necessary conditions for the application of high-dimensional entangled states in quantum information processing.
Regulation of proinflammatory genes by the circulating microRNA hsa-miR-939
Authors: McDonald Marguerite K. , Ramanathan Sujay , Touati Andrew , Zhou Yiqian , Thanawala Rushi U. , Alexander Guillermo M. , Sacan Ahmet , Ajit Seena K. 
Published: August 2016

AbstractCirculating microRNAs are beneficial biomarkers because of their stability and dysregulation in diseases. Here we sought to determine the role of miR-939, a miRNA downregulated in patients with complex regional pain syndrome (CRPS). Hsa-miR-939 is predicted to target several proinflammatory genes, including IL-6, VEGFA, TNFα, NFκB2, and nitric oxide synthase 2 (NOS2A). Binding of miR-939 to the 3′ untranslated region of these genes was confirmed by reporter assay. Overexpression of miR-939 in vitro resulted in reduction of IL-6, NOS2A and NFκB2 mRNAs, IL-6, VEGFA, and NOS2 proteins and NFκB activation. We observed a significant decrease in the NOS substrate l-arginine in plasma from CRPS patients, suggesting reduced miR-939 levels may contribute to an increase in endogenous NOS2A levels and NO, and thereby to pain and inflammation. Pathway analysis showed that miR-939 represents a critical regulatory node in a network of inflammatory mediators. Collectively, our data suggest that miR-939 may regulate multiple proinflammatory genes and that downregulation of miR-939 in CRPS patients may increase expression of these genes, resulting in amplification of the inflammatory pain signal transduction cascade. Circulating miRNAs may function as crucial signaling nodes, and small changes in miRNA levels may influence target gene expression and thus disease.
Rapid discovery and identification of anti-inflammatory constituents from traditional Chinese medicine formula by activity index, LC-MS, and NMR
Authors: Wang Shufang , Wang Haiqiang , Liu Yining , Wang Yi , Fan Xiaohui , Cheng Yiyu 
Published: August 2016

AbstractThe traditional activity-guided approach has the shortcoming of low accuracy and efficiency in discovering active compounds from TCM. In this work, an approach was developed by integrating activity index (AI), liquid chromatography – mass spectrometry (LC-MS), and nuclear magnetic resonance (NMR) to rapidly predict and identify the potential active constituents from TCM. This approach was used to discover and identify the anti-inflammatory constituents from a TCM formula, Gui-Zhi-Jia-Shao-Yao-Tang (GZJSYT). The AI results indicated that, among the 903 constituents detected in GZJSYT by LC-MS, 61 constituents with higher AI values were very likely to have anti-inflammatory activities. And eight potential active constituents of them were isolated and validated to have significant inhibitory effects against NO production on LPS-induced RAW 264.7 cell model. Among them, glycyrrhisoflavone (836), glisoflavanone (893) and isoangustone A (902) were reported to have anti-inflammatory effects for the first time. The proposed approach could be generally applicable for rapid and high efficient discovery of anti-inflammatory constituents from other TCM formulae or natural products.
A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence
Authors: Cabana-Domínguez Judit , Roncero Carlos , Grau-López Lara , Rodríguez-Cintas Laia , Barral Carmen , Abad Alfonso C. , Erikson Galina , Wineinger Nathan E. , Torrico Bàrbara , Arenas Concepció , Casas Miquel , Ribasés Marta , Cormand Bru , Fernàndez-Castillo Noèlia 
Published: August 2016

AbstractCocaine dependence is a complex psychiatric disorder involving both genetic and environmental factors. Several neurotransmitter systems mediate cocaine’s effects, dependence and relapse, being the components of the neurotransmitter release machinery good candidates for the disorder. Previously, we identified a risk haplotype for cocaine dependence in the NSF gene, encoding the protein N-Ethylmaleimide-Sensitive Factor essential for synaptic vesicle turnover. Here we examined the possible contribution to cocaine dependence of a large copy number variant (CNV) that encompasses part of the NSF gene. We performed a case-control association study in a discovery sample (359 cases and 356 controls) and identified an association between cocaine dependence and the CNV (P = 0.013), that was confirmed in the replication sample (508 cases and 569 controls, P = 7.1e-03) and in a pooled analysis (P = 1.8e-04), with an over-representation of low number of copies in cases. Subsequently, we studied the functional impact of the CNV on gene expression and found that the levels of two NSF transcripts were significantly increased in peripheral blood mononuclear cells (PBMC) along with the number of copies of the CNV. These results, together with a previous study from our group, support the role of NSF in the susceptibility to cocaine dependence.
MtDNA analysis reveals enriched pathogenic mutations in Tibetan highlanders
Authors: Kang Longli , Zheng Hong-Xiang , Zhang Menghan , Yan Shi , Li Lei , Liu Lijun , Liu Kai , Hu Kang , Chen Feng , Ma Lifeng , Qin Zhendong , Wang Yi , Wang Xiaofeng , Jin Li 
Published: August 2016

AbstractTibetan highlanders, including Tibetans, Monpas, Lhobas, Dengs and Sherpas, are considered highly adaptive to severe hypoxic environments. Mitochondrial DNA (mtDNA) might be important in hypoxia adaptation given its role in coding core subunits of oxidative phosphorylation. In this study, we employed 549 complete highlander mtDNA sequences (including 432 random samples) to obtain a comprehensive view of highlander mtDNA profile. In the phylogeny of a total of 36,914 sequences, we identified 21 major haplogroups representing founding events of highlanders, most of which were coalesced in 10 kya. Through founder analysis, we proposed a three-phase model of colonizing the plateau, i.e., pre-LGM Time (30 kya, 4.68%), post-LGM Paleolithic Time (16.8 kya, 29.31%) and Neolithic Time (after 8 kya, 66.01% in total). We observed that pathogenic mutations occurred far more frequently in 22 highlander-specific lineages (five lineages carrying two pathogenic mutations and six carrying one) than in the 6,857 haplogroups of all the 36,914 sequences (P = 4.87 × 10−8). Furthermore, the number of possible pathogenic mutations carried by highlanders (in average 3.18 ± 1.27) were significantly higher than that in controls (2.82 ± 1.40) (P = 1.89 × 10−4). Considering that function-altering and pathogenic mutations are enriched in highlanders, we therefore hypothesize that they may have played a role in hypoxia adaptation.