bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic median arcuate ligament release using an anterior approach for median arcuate ligament syndrome
Authors: Kubota Koji , Shimizu Akira , Notake Tsuyoshi , Nakamura Satoshi , Soejima Yuji 
Published: September 2024

AbstractMedian arcuate ligament syndrome (MALS) is a rare condition characterized by nonspecific symptoms, such as abdominal pain, nausea, and vomiting. Furthermore, the development and rupture of pancreaticoduodenal artery aneurysms pose a potentially fatal risk. Median arcuate ligament release (MALR) is useful in the treatment of MALS, with most procedures performed laparoscopically. However, detailed descriptions of laparoscopic MALR (lap‐MALR) procedures are rare. In this study, we performed lap‐MALR via an anterior approach with dissection of the right lateral wall of the celiac artery (CA). For optimal visualization of the right side of the CA, the right branch of the inferior phrenic artery was divided. We believe that this procedure allows the MAL to be released within a sufficient surgical field and without excess or deficiency. Here, we present the details of six patients who underwent lap‐MALR for varying indications; three for pancreaticoduodenal artery aneurysms due to CA obstruction (unruptured, n = 1; ruptured, n = 2), two cases prior to hepato‐biliary‐pancreatic surgery, and one symptomatic case. In all cases, lap‐MALR was performed as described above, and the CA stenosis was successfully released. Our case series demonstrates the safety and reliability of our lap‐MALR procedure in the treatment of MALS‐related disorders, including pancreaticoduodenal artery aneurysms associated with CA compression.
Gender differences in the association between education and late‐life cognitive function in the LifeAfter90 Study: A multiethnic cohort of the oldest–old
Authors: Lam Jennifer O. , Whitmer Rachel A. , Corrada Maria M. , Kawas Claudia H. , Vieira Katherine E. , Quesenberry Charles P. , Gilsanz Paola 
Published: September 2024

AbstractINTRODUCTIONFew studies have examined the relationship between education and cognition among the oldest–old.METHODSCognitive assessments were conducted biannually for 803 participants (62.6% women) of LifeAfter90, a longitudinal study of individuals ≥ 90 years old. Gender differences in associations between education (< high school, high school, some college, and ≥ college) and cognition (verbal episodic memory, semantic memory, and executive function) were examined at baseline and longitudinally using linear mixed models.RESULTSHigher education levels were associated with better cognitive performance at baseline for both men and women. College completion was more strongly associated with better baseline executive function among women. Education‐cognition associations for baseline verbal episodic memory and baseline semantic memory did not differ by gender. Education was not associated with a decline in any domain‐specific cognitive scores, regardless of gender.DISCUSSIONEducation is associated with cognitive function among the oldest–old and varies by gender and cognitive domain at baseline but not over time.Highlights
In the oldest–old, higher education was associated with better cognitive function.
College completion was more strongly associated with executive function in women.
Education was not associated with cognitive decline after age 90 regardless of gender.
Improving education could decrease gaps in cognitive level among older individuals.
Amygdala atrophies in specific subnuclei in preclinical Alzheimer's disease
Authors: Salman Yasmine , Gérard Thomas , Huyghe Lara , Colmant Lise , Quenon Lisa , Malotaux Vincent , Ivanoiu Adrian , Lhommel Renaud , Dricot Laurence , Hanseeuw Bernard J. ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: September 2024

AbstractINTRODUCTIONMagnetic resonance imaging (MRI) segmentation algorithms make it possible to study detailed medial temporal lobe (MTL) substructures as hippocampal subfields and amygdala subnuclei, offering opportunities to develop biomarkers for preclinical Alzheimer's disease (AD).METHODSWe identified the MTL substructures significantly associated with tau‐positron emission tomography (PET) signal in 581 non‐demented individuals from the Alzheimer's Disease Neuroimaging Initiative (ADNI‐3). We confirmed our results in our UCLouvain cohort including 110 non‐demented individuals by comparing volumes between individuals with different visual Braak's stages and clinical diagnosis.RESULTSFour amygdala subnuclei (cortical, central, medial, and accessory basal) were associated with tau in amyloid beta‐positive (Aβ+) clinically normal (CN) individuals, while the global amygdala and hippocampal volumes were not. Using UCLouvain data, we observed that both Braak I‐II and Aβ+ CN individuals had smaller volumes in these subnuclei, while no significant difference was observed in the global structure volumes or other subfields.CONCLUSIONMeasuring specific amygdala subnuclei, early atrophy may serve as a marker of temporal tauopathy in preclinical AD, identifying individuals at risk of progression.Highlights
Amygdala atrophy is not homogeneous in preclinical Alzheimer's disease (AD).
Tau pathology is associated with atrophy of specific amygdala subnuclei, specifically, the central, medial, cortical, and accessory basal subnuclei.
Hippocampal and amygdala volume is not associated with tau in preclinical AD.
Hippocampus and CA1‐3 volume is reduced in preclinical AD, regardless of tau.
A Review of Kirigami/Origami Metasurfaces for Controlling Electromagnetic Waves
Authors: Zheng Yilin , Chen Ke , Feng Yijun 
Published: September 2024

AbstractAdvanced kirigami/origami techniques have enabled the flexible transformation of planar patterns into exquisite three‐dimensional (3D) structures and provided a new paradigm to control electromagnetic waves with remarkable reconfigurability and functionality. The practical applications of kirigami/origami metasurfaces are prospective due to their diversified wave‐manipulation capabilities, which demonstrate advantages such as compactness, lightweightness, deployability, and scalability. In this article, a comprehensive overview of the most recent advancements in the field of kirigami/origami metasurfaces is provided. This includes the concept of kirigami/origami, the practical implementations of kirigami/origami meta‐structures, and the application aspects of kirigami/origami metasurfaces in the control of electromagnetic waves. In the conclusion, future challenges and promising pathways of this field are also envisioned from the own perspectives.
Direction Modulation of Intramolecular Electric Field Boosts Hole Transport in Phthalocyanines for Perovskite Solar Cells
Authors: Xiao Guo‐Bin , Mu Xijiao , Suo Zhen‐Yang , Zhang Xukai , Yu Zefeng , Cao Jing 
Published: September 2024

AbstractTuning the strength of intramolecular electric field (IEF) in conjugated molecules has emerged as an effective approach to boost charge transfer. While direction manipulation of IEF would be a potential way that is still unclear. Here, we leverage the control of peripheral substituents of conjugated phthalocyanines to chemically tune the spatial orientation of IEF. By analyzing the spatial swing of side chains using the Kolmogorov‐Arnold representation and least squares algorithm, a comprehensive mathematical‐physical model has been established. This model enables rapid evaluation of the IEF and maximum hole transport performance induced by spatial swings. The champion phthalocyanine as dopant‐free hole transport material in perovskite solar cell realizes a record performance of 23.41 %. Greatly device stability is also exhibited. This work affords a new way to enhance hole transport capabilities of conjugated molecules by optimizing their IEF vector for photovoltaic devices.
High‐Performance Complementary Electrochromic Batteries using Nb18W16O93 by the Synergistic Effects of Aqueous Al3+/K+ Dual‐Ion
Authors: Wu Cong , Zhang Yining , Shi Hongsheng , Yu Jiameng , Yang Yihang , Zhang Chang , Yu Yi , Liu Wei 
Published: September 2024

AbstractMultivalent ions, especially Al3+ in aqueous electrolyte contributes to higher capacity and color contrast for more sustainable post‐lithium electrochromism and energy storages. However, the lack of suitable cathodic and anodic electrochromic materials is a major challenge for Al‐ion electrochromic batteries, which limits their optical contrast and lifespan. Herein, we report that Wadsley‐Roth phase Nb18W16O93 with open structure achieves Al3+ intercalation/extraction reversibly. The complementary electrochromic energy storage devices based on Nb18W16O93 coupled with Prussian blue using hybrid Al3+/K+ aqueous electrolytes show a fast response, a high capacity and a large coloring efficiency. The superior performances are due to the cations of Al3+ and K+ selectively insert/extract in the electrode of Nb18W16O93 and Prussian blue, respectively. This work provides an effective strategy for high‐performance and low‐cost electrochromic batteries with higher sustainability.
Amplifying Colossal Thermal Expansion of a Martensitic Molecular Crystal through Interlayer Shear‐Induced Side‐Chain Liberation
Authors: Hwang Kyoungtae , Sin Gwangsik , Jang Minwoo , Mi Choi Yoon , Moon Dohyun , Park Hyungbum , Kyu Park Sang 
Published: September 2024

AbstractMolecular crystals capable of colossal thermal expansion (TE) are fascinating owing to their substantial and continuous volume changes and reasonably linear responses to temperature. This makes them promising candidates for micromachine applications. Macroscopic motion is driven by subtle yet cooperative movements of molecules that respond to the thermal motions of dynamic functional units. The study of p‐TIPS‐DSB presented here offers a compelling case highlighting the relationship between the degree of dynamicity of functional units and TE behavior. In its α‐phase, the p‐TIPS‐DSB crystal undergoes an irreversible martensitic transition to the β‐phase, accompanied by significant cooperative interlayer shear. This process substantially enhances the mobility of the side‐chains driven by the increased free volume surrounding them. This nearly doubles the volumetric TE coefficient from 255.3 (10) to 444.9 (32) MK−1, particularly in the actuation direction from 175.0 (7) to 291.7 (20) MK−1, enabling about 4.5 % elongation/contraction. As demonstrated here, p‐TIPS‐DSB exhibits a decent force density (>1.4×107 N m−3) and precise motion control capabilities due to its hysteresis‐free and non‐abrupt TE nature. Furthermore, we demonstrated the limited operating distance of colossal TE materials can be amplified by utilizing levers, highlighting the high potential of these materials for use in micromachines.
Synthesis and Structural Characterization of a Non‐Heme Iron Hyponitrite Complex
Authors: Lengel Michael O. , Dong Hai T. , Lehnert Nicolai 
Published: September 2024

AbstractFlavodiiron NO reductases (FNORs) are important enzymes in microbial pathogenesis, as they equip microbes with resistance to the human immune defense agent nitric oxide (NO). Despite many efforts, intermediates that would provide insight into how the non‐heme diiron active sites of FNORs reduce NO to N2O could not be identified. Computations predict that iron‐hyponitrite complexes are the key species, leading from NO to N2O. However, the coordination chemistry of non‐heme iron centers with hyponitrite is largely unknown. In this study, we report the reactivity of two non‐heme iron complexes with preformed hyponitrite. In the case of [Fe(TPA)(CH3CN)2](OTf)2, cleavage of hyponitrite and formation of an Fe2(NO)2 diamond core is observed. With less Lewis‐acidic [Fe2(BMPA‐PhO)2(OTf)2] (2), reaction with Na2N2O2 in polar aprotic solvent leads to the formation of a red complex, 3. X‐ray crystallography shows that 3 is a tetranuclear iron‐hyponitrite complex, [{Fe2(BMPA‐PhO)2}2(μ‐N2O2)](OTf)2, with a unique hyponitrite binding mode. This species provided the unique opportunity to us to study the interaction of hyponitrite with non‐heme iron centers and the reactivity of the bound hyponitrite ligand. Here, either protonation or oxidation of 3 is found to induce N2O formation, supporting the hypothesis that hyponitrite is a viable intermediate in NO reduction.
Visible Light‐Switchable Lattice Oxygen Sites for Selective C−H and C(O)−C Bond Electrooxidation
Authors: Wang Keping , Huang Jinshu , Hu Jinguang , Wu Mei , Liao Yuhe , Yang Song , Li Hu 
Published: September 2024

AbstractLattice‐oxygen is highly oxidizable, ideal for electrocatalytic C−H oxidation but insufficient alone for C(O)−C bond cleavage due to the non‐removable nature of lattice sites. Here, we present a visible light‐assisted electrochemical method of in situ formulating removable lattice‐oxygen sites in a nickel‐oxyhydroxide (ESE‐NiOOH) electrocatalyst. This catalyst efficiently converts aromatic alcohols and carbonyls with C(O)−C fragments from lignin and plastics into benzoic acids (BAs) with high yields (83–99 %). Without light irradiation, ESE‐NiOOH's intrinsic lattice‐oxygen is non‐removable and inert for C(O)−C bond cleavage. In situ characterizations show light‐induced lattice‐oxygen removal and regeneration via OH− refilling. Theoretical calculations identify the nucleophilic oxygen attack on ketone‐derived carbanion as a rate‐determining step, which can be remarkably facilitated by removable lattice‐oxygen to activate α‐C−H bonds. As a proof‐of‐concept, an “electrochemical funnel” strategy is developed for high‐efficiency upgrading aromatic mixtures with C(O)−C moieties into BA with up to 94 % yield. This in situ removal‐regeneration approach for lattice sites opens an avenue for the tailored design of interfacial electrocatalysts to selectively upcycle waste carbon sources into valuable products.
Evaluation of Active Oxygen Species Derived from Water Splitting for Electrocatalytic Organic Oxidation
Authors: Yang Jiangrong , Xia Tian , Li Hao , Yan Hong , Kong Xianggui , Li Zhenhua , Shao Mingfei , Duan Xue 
Published: September 2024

AbstractActive oxygen species (OH*/O*) derived from water electrolysis are essential for the electrooxidation of organic compounds into high‐value chemicals, which can determine activity and selectivity, whereas the relationship between them remains unclear. Herein, using glycerol (GLY) electrooxidation as a model reaction, we systematically investigated the relationship between GLY oxidation activity and the formation energy of OH* (ΔGOH*). We first identified that OH* on Au demonstrates the highest activity for GLY electrooxidation among various pure metals, based on experiments and density functional theory, and revealed that ΔGOH* on Au‐based alloys is influenced by the metallic composition of OH* coordination sites. Moreover, we observed a linear correlation between the adsorption energy of GLY (Eads) and the d‐band center of Au‐based alloys. Comprehensive microkinetic analysis further reveals a volcano relationship between GLY oxidation activity, the ΔGOH* and the adsorption free energy of GLY (ΔGads). Notably, Au3Pd and Au3Ag alloys, positioned near the peak of the volcano plot, show excellent activity, attributed to their moderate ΔGOH* and ΔGads, striking a balance that is neither too high nor too low. This research provides theoretical insights into modulating active oxygen species from water electrolysis to enhance organic electrooxidation reactions.
Rigid Ligand Confined Synthesis of Carbon Supported Dimeric Fe Sites with High‐Performance Oxygen Reduction Reaction Activity for Quasi‐Solid‐State Rechargeable Zn‐Air Batteries
Authors: Zong Lingbo , Li Mengke , Li Ping , Fan Kaicai , Wang Lei 
Published: September 2024

AbstractDimeric metal sites (DiMSs) in carbon‐based single atom catalysts (SACs) offer distinct advantages in optimizing the adsorption energies of the catalytic intermediates and reaction pathways over single atom sites, which inspires the investigations on the rational design of DiMSs‐based SACs and the accurate discernment of catalytic mechanisms. Here, dimeric Fe sites on carbon blacks (DiFe‐N/CBs) are prepared using the precursor of metal‐organic complex with a controlled structure, and the rigid ligand confinement secures the preservation of dimeric Fe sites during the thermal treatment. DiFe‐N/CBs shows excellent electrocatalytic performance for oxygen reduction reaction (ORR) with a high half‐wave potential of 0.917 V, and excellent durability with negligible activity decay. Theoretical studies reveal that the dimeric Fe sites have an optimal adsorption of OOH* with the Yeager‐type binding, illustrating the advantages of DiMSs over SAs in catalyzing ORR. The rechargeable aqueous and quasi‐solid‐state Zn‐air batteries assembled using DiFe‐N/CBs‐based air cathodes achieve small voltage gaps after long term charge/discharge test, showing great promises for practical applications. This synthetic strategy serves a novel platform to produce a scope of catalysts incorporating multimeric metal sites, and studies on the catalytic mechanism lay the foundation for establishing cooperative effect for multidentate adsorption reactions.
Reduction of Carboxamides Into Amines Catalyzed by La[NH‐2,6‐iPr2‐4‐FcC6H2]3/HBpin
Authors: Ye Qiujin , Wang Yukun , Chen Jue , Luo Yunjie 
Published: September 2024

ABSTRACTReduction of carboxamides is an efficient approach to obtain the corresponding amines, albeit it is one of the most problematic. In this work, by use of pinacolborane (HBpin) as a reductant, the rare‐earth metal tris (arylamido) complex supported by a ferrocenyl‐modified arylamido ligand La[NH‐2,6‐iPr2‐4‐FcC6H2]3 was employed as a precatalyst for primary and secondary amide reductions. This catalyst system exhibited high activity toward hydroborative reduction of amides to amines under mild conditions, as well good tolerance for heteroatoms and functional groups in the reduction. A lanthanide hydride was experimentally verified as the active species and the reduction mechanism was proposed.
Morphology and properties of carbon black‐filled thermoplastic vulcanizate (TPV) composites based on hydrogenated acrylonitrile butadiene rubber and thermoplastic polyester elastomer
Authors: Cui Ziwen , Jing Yuanrong , Liu Lianxu , Liu Yingjun , Du Aihua 
Published: September 2024

AbstractThe unique morphology of thermoplastic vulcanizates (TPVs) reveals a significant correlation between the microstructure and performance, and the development of high‐performance TPV composites for specialized applications has become a current research priority. This study is devoted to developing heat‐ and oil‐resistant TPV composites filled with carbon black (CB) based on hydrogenated acrylonitrile butadiene rubber (HNBR) and thermoplastic polyester elastomer (TPEE) following the masterbatch procedure of dynamic vulcanization. Herein, it focuses on the effects of CB content on the morphology, filler network structure, and properties of the TPV/CB composites. As observed by morphological studies, CB nanoparticles are interconnected and aggregated to form a dual network structure of rubber and CB particles in the composite. With the increasing CB content, it's demonstrated that dual networks have enhanced and shifted to rigid. Consequently, the hardness, thermal stability, and oil resistance of TPV/CB composites are improved, with a 104% elevation in the stress at 300% strain. The flowability in the molten state, toughness (the elongation at break decreased from 690% to 310%), and elasticity deteriorated by oversized (0.5 ~ 1.2 μm) CB agglomerates and rigid rubber particles. This study gives new insight into the microstructure‐properties relationship of TPVs, offering theoretical guidance for fabricating HNBR‐based TPV composites.
A DNA Aptamer for 2‐Aminopurine: Binding‐Induced Fluorescence Quenching
Authors: Datta Meheta , Liu Juewen 
Published: September 2024

Abstract2‐Aminopurine (2AP) is a fluorescent analog of adenine, and its unique properties make it valuable in various biochemical and biotechnological applications. Its fluorescence property probes local dynamics in DNA and RNA because stacking with the surrounding bases quench its fluorescence. 2AP‐labeled DNA or RNA sequences have been used for the detection of genetic mutations, viral RNA, or other nucleic acid‐based markers associated with diseases like cancer and infectious diseases. In this study, we isolated aptamers for 2AP using the library immobilization capture‐SELEX technique. A dominating aptamer family was isolated after 15 rounds of selection. The Kd values for the most abundant 2AP1 aptamer are 209 nM in a fluorescence assay and 72 nM in an isothermal titration calorimetry test. A 32 nM 2AP limit of detection was tested based on its intrinsic fluorescence change upon aptamer binding. Additionally, we conducted some mutation analysis. Furthermore, we tested the selectivity of this aptamer and discovered that it can bind adenine and adenosine with approximately 100‐fold lower affinity than 2AP.
Improvement of fluorescence properties by surface modification of CdS‐ZnS quantum dots by thiol compounds and its application as a sensitive fluorescence probe for copper ion detection
Authors: Ghasemi Seyfollah , Samadi‐Maybodi Abdolraouf 
Published: September 2024

AbstractThe capped CdS‐ZnS quantum dots (QDs) were synthesized with various thiol capping agents of glycolic acid (TGA), mercaptosuccinic acid (MSA), and L‐cysteine (LCY) and used as fluorescence probe for determination of Cu (II) ions. The method of two‐level three‐factor full‐factorial experiment design was used to achieve the best optical fluorescence emission. Results revealed that Cu (II) ions can effectively quench the emission of QDs, and the fluorescence intensity is linearly decreased with increasing Cu (II) ion concentration. The limit of detection for CdS‐ZnS@ QDs capped with TGA, MSA, and LCY was obtained at 1.15 × 10−7, 1.32 × 10−7, and 2.19 × 10−7 mol L−1, respectively, with linear dynamic range of 3.13 × 10−6 to 1.41 × 10−4 mol L−1. Luminescence quantum yields of CdS‐ZnS@LCY, CdS‐ZnS@MSA, and CdS‐ZnS@TGA were obtained at 4.17, 1.92, and 2.47, respectively. Results indicated that no significant quenching occurred in the presence of the other metal ions. The binding constant (Kb) of capped CdS‐ZnS@ QDs with Cu2+ and the other metal ions was also investigated and discussed. The Kb value for Cu2+ was obtained considerably more than that the other ions. This work presents a new and sensitive method for determination of Cu2+ ion.
High Content Screening Assay of Inhibitors of the Legionella Pneumophila Histone Methyltransferase RomA in Infected Cells
Authors: Barbachowska Magdalena , Harivel Thomas , Nicchi Sonia , Danckaert Anne , Ghazarian Marine , Chiaravalli Jeanne , Buchrieser Carmen , Rolando Monica , Arimondo Paola B. 
Published: September 2024

AbstractResistance to anti‐microbial agents is a world‐wide health threat. Thus, there is an urgent need for new treatments. An alternative approach to disarm pathogens consists in developing drugs targeting epigenetic modifiers. Bacterial pathogens can manipulate epigenetic regulatory systems of the host to bypass defences to proliferate and survive. One example is Legionella pneumophila, a Gram‐negative intracellular pathogen that targets host chromatin with a specific, secreted bacterial SET‐domain methyltransferase named RomA. This histone methyltransferase specifically methylates H3 K14 during infection and is responsible for changing the host epigenetic landscape upon L. pneumophila infection. To inhibit RomA activity during infection, we developed a reliable high‐content imaging screening assay, which we used to screen an in‐house chemical library developed to inhibit DNA and histone methyltransferases. This assay was optimised using monocytic leukemic THP‐1 cells differentiated into macrophages infected with L. pneumophila in a 96‐ or 384‐well plate format using the Opera Phenix (Perkin Elmer) confocal microscope, combined with Columbus software for automated image acquisition and analysis. H3 K14 methylation was followed in infected, single cells and cytotoxicity was assessed in parallel. A first pilot screening of 477 compounds identified a potential starting point for inhibitors of H3 K14 methylation.