bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tattooing and psoriasis: a case series and review of the literature
Authors: Kluger Nicolas , Estève Eric , Fouéré Sébastien , Dupuis‐Fourdan Florence , Jegou Marie‐Hélène , Lévy‐Rameau Chantal 
Published: May 2017

AbstractBackgroundKoebner phenomenon (KP) affects from a quarter to a third of the patients with psoriasis and can occur on tattoosMaterial and methodsWe retrospectively reviewed a case series of seven tattooed patients with an isomorphic response on their tattoos or partial psoriasis patches on their tattoos. We collected the demographic data, the past history of psoriasis, the clinical presentation, and the outcomes. We also performed a review of the literature. We tried to classify the different clinical profile of KP/psoriasis on tattoos accordingly.ResultsSix men and one woman with a median age of 36 ± 6.4 years old were included. Five disclosed a KP in a recent tattoo within days to 1 month after its completion. Fifteen additional cases were collected from the literature (8 men, median age 22 ± 8.2 years old). The delay of psoriasis flare‐up after tattooing was rather short, from a few weeks to several months. We found a high variability in the clinical presentation with five clinical subtypes/profiles of psoriasis on tattoos. A possible confusion between “genuine” KP on tattoos and the coincidental occurrence of psoriasis patches on tattoos is possible in some cases of the literature. Patients were mainly managed locally, rarely by systemic treatments or biologics.ConclusionKoebner phenomenon on tattoos may occur in patients with psoriasis under various forms. The evolution is benign, and psoriasis is not a contraindication for tattooing, but patients need proper counseling before getting tattooed.
Characterisation and food application of curcumin bound to sodium caseinate–polysaccharide electrostatic complexes
Authors: Cho Hyunnho , Lee Hee Jae , Yu Ki Seon , Choi Yu Mi , Hwang Keum Taek 
Published: May 2017

SummaryElectrostatic complexes between sodium caseinate (NaCas) and high‐methoxyl pectin (HMP) or carboxymethyl cellulose (CMC) were used to stabilise curcumin in this study. Effect of pH on the characteristics of the complex was evaluated, finding pH 4 was optimum. Zeta potential of NaCas‐CMC (−33.59) was larger than that of NaCas‐HMP (−22.19) at pH 4, implying higher colloidal stability. The complexes protected curcumin from heat treatment, and antioxidant activity of curcumin bound to the complexes was similar to that of native curcumin. Incorporation of sucrose partially prevented freeze drying‐induced aggregation of the complex, especially for NaCas‐HMP. In a model beverage, curcumin bound to the complexes showed higher colour stability. In vitro bioaccessibility of curcumin bound to NaCas‐HMP (53.0%) and NaCas‐CMC (51.6%) was higher than the native curcumin (21.4%). This study suggests that curcumin bound to the complexes, especially NaCas‐HMP‐bound curcumin may be used as a potential food colourant where transparency is needed.
Evaluation of modified casings and chitosan‐PVA packaging on the physicochemical properties of cooked Sichuan sausages during long‐term storage
Authors: Feng Chao‐Hui , Liu Yao‐Wen , Makino Yoshio , García Martín Juan Francisco , Cummins Enda 
Published: May 2017

SummaryThe effects of a modified casing and chitosan‐poly‐vinyl alcohol antimicrobial packaging (CP packaging) on sausage colour, texture, microbial spoilage and volatile compounds after 29‐days storage were investigated. Casings were modified by surfactant solution (composed of soy lecithin and soy oil) and lactic acid. For samples stored in CP packaging, there were no significant differences between day 1 and day 29 in relation to sausage hardness and springiness (P > 0.05). Redness increased over storage time regardless of treatments and packagings. Total plate counts of samples packaged by CP packaging were lower than 1 log cfu g−1 during 29‐days storage. Cyclohexene, 1‐methyl‐4‐(1‐methylethylidene)‐ and α‐copaene were found in samples with control casings and CP packaging after 15‐days storage. The improved characteristics of the natural casing will enable meat processors or manufactures to enhance sausage production with a low sausage burst incidence, while the CP packaging will inhibit the intensive microbial growth.
Optimisation of sourdough bread incorporation into wheat bread by response surface methodology: Bioactive and nutritional properties
Authors: Hayta Mehmet , Hendek Ertop Muge 
Published: May 2017

SummaryThe optimisation of the quantity of sourdough (A) prepared with two different fermentation methods, [spontaneous fermentation (F1) vs. starter of lactic acid bacteria‐added fermentation (F2)], instant active dry yeast (B) and wheat bran (C) for a nutritionally improved bread formulation has been studied by evaluating the bioavailability and bioactive properties. The bread produced according to the optimised formula and fermentation types of F1 (OBF1) and F2 (OBF2) was compared with control bread (CB). The optimised levels for F1 were 11.45% for sourdough, 1.10% for dry yeast and 1.58% for wheat bran and for F2 6.99% for sourdough, 1.02% for dry yeast and 38.84% for wheat bran. The addition of sourdough significantly (P < 0.05) affected antioxidant activity, total phenolic content, in vitro ash and protein digestibility, and enzyme resistance starch contents of bread. The F1 fermentation method was found to be more effective in terms of bread properties examined.
Effect of dry heat stabilisation on the functional properties of rice bran proteins
Authors: Lv Shi‐Wen , Sun Li‐Hui , Zhao Shu‐Yan , Bao Yong‐Ming 
Published: May 2017

SummaryRice bran was stabilised by dry heat method at 120 °C for 10–60 min, and then, protein was extracted from stabilised rice bran using weak alkali method. The storage characteristics of stabilised rice bran and the influences of dry heat pretreatment on the physicochemical properties of rice bran protein isolate were also evaluated. The results indicated that dry heat pretreatment could not only prevent rancidity of rice bran effectively, but also improve some functional properties of rice bran proteins, such as emulsifying properties, oil holding capacity, and water holding capacity. However, foaming properties and protein solubility were slightly destroyed because of heating. Rice bran was pretreated at 120 °C for 10 or 20 min and then extracted at pH 9.5, and the protein yields were 50.09% and 46.98%, respectively. Therefore, the dry heat treatment at 120 °C for 10 or 20 min was a suitable alternative process in stabilisation of rice bran.
Life history traits and previous exposure predict resistance to UV irradiation in the freshwater cnidarian Hydra oligactis
Authors: Tökölyi Jácint , Kozma Beatrix , Sebestyén Flóra , Miklós Máté , Barta Zoltán 
Published: May 2017

AbstractAbiotic stress is an important source of mortality for cnidarians and is likely to be a major factor shaping their life histories. In freshwater hydra, the ability to withstand exogenous sources of stress varies between species and populations, but little is known about the factors responsible for this variation. Here, we investigated resistance to UV irradiation in Hydra oligactis, a common temperate freshwater cnidarian. We collected polyps from 12 populations and propagated these asexually under standard conditions in the laboratory to obtain 69 laboratory clonal lines with a total of 324 polyps of different age. We measured the size of polyps and recorded their budding rate. In addition, a subset of animals was exposed to hormetic treatment, where experimental animals received a short, sublethal irradiation 2 d before testing their resistance to a higher dose. We investigated how life history traits (age, size, and budding rate), hormetic treatment, and the interaction between life history traits and hormetic treatment relate to the ability of hydra polyps to tolerate high doses of UV irradiation. In multivariate models controlling for the effect of other variables, stress tolerance was positively related to age (lower tolerance in freshly detached buds compared to adult hydra) and size (higher tolerance in polyps with a large body column). Budding rate was negatively associated with stress tolerance. Hormetic treatment increased resistance to UV irradiation, but we found no evidence for an interaction between hormetic response and any of the life history traits, suggesting that the ability to upregulate physiological defense mechanisms after exposure to mild stress does not depend on the life history background of the individuals.
Anion transport through ceramic electrodialysis membranes made with hydrated cerium dioxide
Authors: Mora‐Gómez Julia , García‐Gabaldón Montserrat , Martí‐Calatayud Manuel C. , Mestre Sergio , Pérez‐Herranz Valentín 
Published: May 2017

AbstractIn this research, low‐cost ceramic anion‐exchange membranes have been developed from porous supports manufactured, using a chamotte as a pore former. An inorganic anion‐exchanger (hydrated cerium dioxide) has been deposited into the support and fixed by thermal treatment. The effects of some process variables (such as the temperature of the thermal treatment or the pH of the electrolyte) on the properties of the anion‐exchange membranes have been investigated. The electrochemical performance of the resulting membranes has been compared to that exhibited by ceramic anion‐exchange membranes based on another anion exchanger (hydrated zirconium dioxide) deposited into alumina‐kaolin supports. The temperature of the thermal treatment applied to fix the hydrated cerium dioxide (HCeD) does not affect the structure nor the electrochemical properties of the membranes. The porosity of the supports obtained, using a chamotte as the pore former was lower than that of the alumina‐kaolin ones, which led to a lower deposition of hydrated cerium dioxide than that obtained for hydrated zirconium dioxide (HZrD) in alumina‐kaolin supports. The higher porosity registered for the HZrD‐based membrane also implies higher membrane conductivities. The selective transport of anions through the membranes was enhanced by increasing the number of infiltrating steps, as confirmed from current to voltage curves. However, this behavior was only apparent at acidic or neutral pH, thus confirming the amphoteric character of the anion‐exchanger. Comparing the γ parameter (equivalents of ion exchanger per gram of deposited oxide), it is concluded that the porosity of the ceramic supports, consequence of their distinct microstructure, is the main parameter responsible for the difference in the ion‐exchange capacity obtained for HZrD and HCeD membranes. Consequently, the CeO2 particles used in this work are also good candidates to impart ion‐exchange properties to microporous ceramic supports.
Validation of electrical ostial pulmonary vein isolation verified with a spiral inner lumen mapping catheter during second‐generation cryoballoon ablation
Authors: Miyazaki Shinsuke , Kajiyama Takatsugu , Watanabe Tomonori , Taniguchi Hiroshi , Nakamura Hiroaki , Hamaya Rikuta , Kusa Shigeki , Igarashi Miyako , Hachiya Hitoshi , Hirao Kenzo , Iesaka Yoshito 
Published: May 2017

AbstractBackgroundAchieve catheters are cryoballoon guidewires that enable pulmonary vein (PV) potential mapping. The single catheter approach in conjunction with the Achieve catheter is currently standard practice in second‐generation cryoballoon ablation, yet circumferential mapping catheters are the gold standard for evaluating PV isolation (PVI). The study sought to validate the ostial PVI verified by an Achieve catheter alone.MethodsOne hundred fifty‐one paroxysmal atrial fibrillation patients undergoing PVI using exclusively 28‐mm second‐generation cryoballoons were enrolled. PV recordings were analyzed during (real‐time recordings) and after cryoballoon applications with 20‐mm Achieve mapping catheters, and subsequently validated by 20‐mm conventional circumferential mapping catheters.ResultsOut of 596 PVs, 576 (96.6%) were isolated using cryoballoons, and 20 required touch‐up ablation. PVI was verified during cryoballoon applications with real‐time monitoring in 299, and after applications in 280 PVs by Achieve catheters alone. The time‐to‐isolation was 27.2 ± 22.0 seconds. Validation with standard circumferential mapping catheters confirmed ostial PVIs in 296 of 299 (99.0%) PVs that real‐time PVI was obtained during applications, and in 242 of 280 (86.5%) PVs that PV activities were not visible during applications and PVI was verified after the applications. The accuracy of ostial PVIs with Achieve catheters in PVs without obtaining real‐time PV recordings was 40/47 (85.1%), 58/65 (89.2%), 77/79 (97.5%), 61/81 (75.3%), and 6/8 (75.0%) in left superior, left inferior, right superior, right inferior, and left common PVs, respectively.ConclusionsIn second‐generation 28‐mm cryoballoon ablation, verification of ostial PVIs using Achieve mapping catheters alone might not be sufficient to accurately confirm an ostial PVI when real‐time PVI was not obtained.
Authority, Autonomy, and Deception: Evaluating the Legitimacy of Parental Authority and Adolescent Deceit
Authors: Gingo Matthew , Roded Alona D. , Turiel Elliot 
Published: May 2017

This research examined adolescents’ judgments about lying to avoid parental control over different types of activities. Participants (N = 66, Mage = 16.38, 73% European American) were interviewed about hypothetical situations describing adolescents who defied parental directives and lied about their defiance. Judgments about the legitimacy of parents’ directives and protagonists’ deception differed by types of parent relationship with adolescents (mutual or unilateral). Directives were least accepted, and deception was most accepted, in the context of unilateral relationships. Judgments also differed by domain of the action (personal, prudential, or conventional). Participants were least accepting of parental directives, and most accepting of deception about personal activities. Findings indicate that adolescents value honesty and parental authority, but sometimes give priority to concerns with autonomy and mutuality.
Melatonin inhibits neuronal dysfunction‐associated with neuroinflammation by atopic psychological stress in NC/Nga atopic‐like mouse models
Authors: Park Gunhyuk , Lee Seung Hoon , Oh Dal‐Seok , Kim Yong‐ung 
Published: May 2017

AbstractAtopic dermatitis (AD), also known as atopic eczema, is chronic pruritic skin disease. AD can increase psychological stress as well, increasing glucocorticoid release and exacerbating the associated symptoms. Chronic glucocorticoid elevation disturbs neuroendocrine signaling and can induce neuroinflammation, neurotoxicity, and cognitive impairment; however, it is unclear whether AD‐related psychological stress elevates glucocorticoids enough to cause neuronal damage. Therefore, we assessed the effects of AD‐induced stress in a mouse AD model. AD‐related psychological stress increased astroglial and microglial activation, neuroinflammatory cytokine expression, and markers of neuronal loss. Notably, melatonin administration inhibited the development of skin lesions, scratching behavior, and serum IgE levels in the model mice, and additionally caused a significant reduction in corticotropin‐releasing hormone responsiveness, and a significant reduction in neuronal damage. Finally, we produced similar results in a corticosterone‐induced AD‐like skin model. This is the first study to demonstrate that AD‐related psychological stress increases neuroendocrine dysfunction, exacerbates neuroinflammation, and potentially accelerates other neurodegenerative disease states.
Immune correlates of hepatitis B surface antigen spontaneous seroconversion in hepatitis B e antigen negative chronic hepatitis B patients
Authors: Vyas Ashish Kumar , Sharma Barjesh Chander , Sarin Shiv Kumar , Trehanpati Nirupma 
Published: May 2017

AbstractBackgroundHepatitis B surface antigen (HBsAg) seroconversion in HBeAg −ve chronic hepatitis B (CHB) infection is rare, possibly due to poor antigen processing and impaired humoral response. We investigated the role of dendritic cells (DCs), T follicular helper (TFH) cells and plasma B cells in seroconversion.MethodsHBeAg −ve (n=135) CHB patients with raised ALT at baseline were followed up. Patients undergoing HBsAg seroconversion (Gr. I, n=11) were compared with non‐converters with low (Gr. II, n=17, HBV DNA<2000 IU/mL) or high HBV DNA (Gr. III, HBV DNA >2000 IU/mL, n=17). We measured cell phenotypes (TFH, B and DCs), HBV specific T‐cell functionality [using pooled overlapping surface and core peptides], IL21 levels and gene expression analysis by qRT‐PCR.ResultsPatients in Gr. I compared to Gr. II and III, had higher IL‐21 levels (865 vs 276 vs 111 pg/mL, P=<.0001), TFH (CD4+CXCR5+) cells (12.3 vs 4.67 vs 2.77, P=<.001), inducible T‐cell co‐stimulator (ICOS) expression on TFH cells (20.0 vs 13.0 vs 13.68, P=.01), HBsAg specific IL‐17 (9.40 vs 2.33 vs 2.61, P=<.001) and TNF‐α secreting TFH17 cells (82 vs 1.43 vs 2.33, P=<.001), plasma B (CD19+CD38+) cells (15.0 vs 5.08 vs 5.57, P=<.001), myeloid (17.80 vs 5.39 vs 2.70, P=<.001) and plasmocytoid DCs (2.6 vs 0.43 vs 0.21, P=<.001). Plasma B‐cell frequency (R2=.64, P=.01) and IL‐21 levels (R2=.52, P=.003) correlated with anti‐HBs titres in patients with HBsAg seroconversion.ConclusionsDendritic cell and TFH cell mediated responses regulate humoral responses against HBV and play a major role in HBsAg seroconversion in CHB patients.
Bergmann glia translocation: a new disease marker for vanishing white matter identifies therapeutic effects of Guanabenz treatment
Authors: Dooves S. , Bugiani M. , Wisse L. E. , Abbink T. E. M. , van der Knaap M. S. , Heine V. M. 
Published: May 2017

AimVanishing White Matter (VWM) is a devastating leucoencephalopathy without effective treatment options. Patients have mutations in the EIF2B1‐5 genes, encoding the five subunits of eIF2B, a guanine exchange factor that is an important regulator of protein translation. We recently developed mouse models for VWM that replicate the human disease. To study disease improvement after treatment in these mice, it is essential to have sensitive biomarkers related to disease stage. The Bergmann glia of the cerebellum, an astrocytic subpopulation, translocate into the molecular layer in symptomatic VWM mice and patients. This study looked at the prospects of using Bergmann glia pathology as an objective disease marker for VWM.MethodsWe defined a new quantitative measurement of Bergmann glia pathology in the cerebellum of VWM mice and patients. To test the sensitivity of this new marker for improvement, VWM mutant mice received long‐term treatment with Guanabenz, an FDA‐approved anti‐hypertensive agent affecting eIF2B activity.ResultsBergmann glia translocation was significantly higher in symptomatic VWM mice and VWM patients than in controls and worsened over the disease course. Both Bergmann glia pathology and cerebellar myelin pathology improved with Guanabenz treatment in mice, showing that Bergmann glia translocation is a sensitive measurement for improvement.ConclusionsBergmann glia translocation can be used to objectively assess effects of treatment in VWM mice. Future treatment strategies involving compounds regulating eIF2 phosphorylation might benefit VWM patients.
Virtually No Effect? Different Uses of Classroom Computers and their Effect on Student Achievement
Authors: Falck Oliver , Mang Constantin , Woessmann Ludger 
Published: May 2017

AbstractMost studies find little to no effect of classroom computers on student achievement. We suggest that this null effect may combine positive effects of computer uses without equivalently effective alternative traditional teaching practices and negative effects of uses that substitute more effective teaching practices. Our correlated random effects models exploit within‐student between‐subject variation in different computer uses in the international TIMSS test. We find positive effects of using computers to look up information and negative effects of using computers to practice skills, resulting in overall null effects. Effects are larger for students with high socioeconomic status and mostly confined to developed countries.
The therapeutic alliance in different mental disorders: A comparison of patients with depression, somatoform, and eating disorders
Authors: Mander Johannes , Neubauer Andreas B. , Schlarb Angelika , Teufel Martin , Bents Hinrich , Hautzinger Martin , Zipfel Stephan , Wittorf Andreas , Sammet Isa 
Published: May 2017

ObjectiveThe therapeutic alliance is intensively investigated in psychotherapy research. However, there is scarce research on the role of the specific diagnosis of the patient in the formation of the therapeutic alliance. Hence, the aim of this study was to address this research gap by comparing the alliance in different mental disorders.DesignOur sample comprised 348 patients (mean age = 40 years; 68% female; 133 patients with depression, 122 patients with somatoform disorders, and 93 patients with eating disorders).MethodsPatients completed the Working Alliance Inventory and measures of therapeutic outcome in early, middle, and late stages of inpatient psychotherapy. We applied multivariate multilevel models to address the nested data structure.ResultsAll three disorder groups experienced positive alliances that increased across the course of therapy and showed similar alliance–outcome relations that were of comparable strengths as in current meta‐analyses. However, we found perspective incongruence of alliance ratings from patient and therapist in the three disorder groups.ConclusionsOur results generally indicate that the working alliance is of importance irrespective of the specific mental disorder. Perspective incongruence feedback of working alliance experiences could help to strengthen coordination between patient and therapist and thereby improve the therapeutic process. Further implications of these findings are discussed.Practitioner points

We found no differences in the strengths of alliance ratings and alliance–outcome associations in depressive, somatoform, and eating disorder patients.

This indicates that the working alliance is of general clinical importance irrespective of the disorder group and should be a central target in all therapies.

We found perspective incongruence in alliance ratings between patient and therapist in all three disorder groups.

Perspective incongruence feedback of working alliance experiences could help to strengthen coordination between patient and therapist and thereby improve the therapeutic process.