bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosis – Different presentation for designer drugs compared to cannabis abusers?
Authors: Dumitrescu F. 
Published: June 2017

Introduction“Bath salts” target the endocannabinoid system in a similar manner to cannabis. In the case of designer drug misuse, subjects seem to be at higher risk of psychotic symptoms.AimsTo investigate the nature and frequency of psychotic symptoms associated with cannabis and/or bath salts misuse in a male inpatient population.MethodThe files of 107 patients admitted to the department of addictions, “Al. Obregia” Psychiatric Hospital Bucharest July 2015–July 2016 were reviewed. Cases had a diagnosis of psychotic disorder with recorded cannabis/bath salts abuse.ResultsMean age was 26.65 years old (STDV = 5.9). Mean duration of use was of 83.94 months – cannabis; 60.48 months – bath salts and 33.75 months – both substances (BS). Sixty-three patients (73.3%) presented disorganised behaviour; 55.8% (n = 48) formal thought disorder; 45% (n = 39) paranoid delusions. A strong positive association between the length of use of cannabis and disorganised behaviour (n = 33; r = 0.05; P < 0.05) was found. Grandiose ideation was frequent in cannabis users. (X2 = 4.1; n = 0.03; P < 0.05). Multidrug abuse was associated with increased formal thought disorders compared to subjects with cannabis abuse (X2 = 10.9; n = 0.001; P < 0.05). Negative symptoms were more frequent with bath salts users than with users of both substances (X2 = 13.4; X2 = 23.21; X2 = 16.8; P < 0.05).ConclusionPositive psychotic symptoms were associated with cannabis and BS abuse, while bath salts promoted negative symptoms.Disclosure of interestThe author has not supplied his/her declaration of competing interest.
Risk factors for multiple suicidality in Hungary
Authors: Toth M.D. , Osváth P. , Vörös V. , Futó K. , Ágnes N. , Székely A. , Purebl G. , Fekete S. 
Published: June 2017

IntroductionSuicide rate in Hungary is among the highest in the European Union (2015: 18.9/100,000 inhabitant). Although there is no national registration system of suicide attempts in Hungary, according to previous studies Hungarian Romas have three times higher suicide attempt rate than non-Romas.ObjectivesThe aim of this study was to explore socio-demographic and mental health risk factors of multiple suicide attempts in Hungary.MethodsA total of 1547 suicide attempts were assessed via retrospective data analysis using patient records. Data on socio-demographic variables, psychiatric diagnoses, methods and reported reasons of suicide attempts were investigated. Binary logistic regression analyses were performed to identify potential risk factors for multiple suicide attempts.ResultsThe ratio of multiple attempters were 37.7% in the sample, with a Roma predominance (Roma: 51.8%, non-Roma: 34.8%, χ2(1) = 27.64; P < 0.001). Of the potential factors examined, Roma ethnicity (OR: 2,03; CI: 1.53–2.70; P < 0.001), economic inactivity (OR: 1.7; CI: 1.36–2.18; P < 0.001), mood disorders (OR: 1.58; CI: 1.25–1.99; P < 0.001), personality disorders (OR: 2.09; CI: 1.45–3.01; P = 0.00), organic mental disorders (OR: 1.76; CI: 1.01–3.07; P = 0.44) and mistreatment as reported reasons (OR: 3.95; CI: 1.17–13.32; P = 0.02) were found as significant risk factors of multiple suicide attempts.ConclusionNational registration of suicide attempts would be necessary for a more thorough analysis. Beside the more advanced treatment of mental health disorders, increased efforts in prevention are recommended with a special focus of low SES groups and Roma ethnicity. The specific background factors in Roma ethnic group should be further examined.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Extrapolating body masses in large terrestrial vertebrates
Authors: Campione Nicolás E. 
Published: June 2017

AbstractDespite more than a century of interest, body-mass estimation in the fossil record remains contentious, particularly when estimating the body mass of taxa outside the size scope of living animals. One estimation approach uses humeral and femoral (stylopodial) circumferences collected from extant (living) terrestrial vertebrates to infer the body masses of extinct tetrapods through scaling models. When applied to very large extinct taxa, extant-based scaling approaches incur obvious methodological extrapolations leading some to suggest that they may overestimate the body masses of large terrestrial vertebrates. Here, I test the implicit assumption of such assertions: that a quadratic model provides a better fit to the combined humeral and femoral circumferences-to-body mass relationship. I then examine the extrapolation potential of these models through a series of subsetting exercises in which lower body-mass sets are used to estimate larger sets. Model fitting recovered greater support for the original linear model, and a nonsignificant second-degree term indicates that the quadratic relationship is statistically linear. Nevertheless, some statistical support was obtained for the quadratic model, and application of the quadratic model to a series of dinosaurs provides lower mass estimates at larger sizes that are more consistent with recent estimates using a minimum convex-hull (MCH) approach. Given this consistency, a quadratic model may be preferred at this time. Still, caution is advised; extrapolations of quadratic functions are unpredictable compared with linear functions. Further research testing the MCH approach (e.g., the use of a universal upscaling factor) may shed light on the linear versus quadratic nature of the relationship between the combined femoral and humeral circumferences and body mass.
Diagnosis and molecular detection of Paenibacillus larvae, the causative agent of American foulbrood in honey bees in Saudi Arabia
Authors: Ansari Mohammad Javed , Al-Ghamdi Ahmad , Nuru Adgaba , Ahmed Ashraf Mohamed , Ayaad Tahany H. , Khan Khalid Ali , Al-Waili Noori 
Published: June 2017

AbstractApis mellifera jemenitica, the only indigenous honey bee race of Saudi Arabia, is well adapted to the harsh local environmental conditions. A large-scale field survey was conducted to screen major Saudi Arabian beekeeping locations for infection byPaenibacillus larvae. Paenibacillus larvaeis one of the major bacterial pathogens of honey bee broods and is the causative agent of American foulbrood disease. Larvae from samples suspected of infection were collected from different apiaries and homogenized in phosphate-buffered saline. Bacteria were isolated on MYPGP agar medium. Two bacterial isolates, ksuPL3 and ksuPL5 (16S rRNA GenBank accession numbers, KR780760 and KR780761, respectively), were subjected to molecular identification usingP. larvae-specific primers. A BLAST sequence analysis revealed that the two isolates wereP. larvaewith more than 98% sequence identity. This detection ofP. larvaein the indigenous honey bee is the first recorded incidence of this pathogen in Saudi Arabia. This study emphasizes the need for the relevant authorities to take immediate steps towards treating and limiting the spread of this disease throughout the country.
Single-molecule quantum dot as a Kondo simulator
Authors: Hiraoka R. , Minamitani E. , Arafune R. , Tsukahara N. , Watanabe S. , Kawai M. , Takagi N. 
Published: June 2017

AbstractStructural flexibility of molecule-based systems is key to realizing the novel functionalities. Tuning the structure in the atomic scale enables us to manipulate the quantum state in the molecule-based system. Here we present the reversible Hamiltonian manipulation in a single-molecule quantum dot consisting of an iron phthalocyanine molecule attached to an Au electrode and a scanning tunnelling microscope tip. We precisely controlled the position of Fe2+ ion in the molecular cage by using the tip, and tuned the Kondo coupling between the molecular spins and the Au electrode. Then, we realized the crossover between the strong-coupling Kondo regime and the weak-coupling regime governed by spin–orbit interaction in the molecule. The results open an avenue to simulate low-energy quantum many-body physics and quantum phase transition through the molecular flexibility.
Possible Weyl fermions in the magnetic Kondo system CeSb
Authors: Guo Chunyu , Cao Chao , Smidman Michael , Wu Fan , Zhang Yongjun , Steglich Frank , Zhang Fu-Chun , Yuan Huiqiu 
Published: June 2017

AbstractMaterials where the electronic bands have unusual topologies allow for the realisation of novel physics and have a wide range of potential applications. When two electronic bands with linear dispersions intersect at a point, the excitations could be described as Weyl fermions, which are massless particles with a particular chirality. Here we report evidence for the presence of Weyl fermions in the ferromagnetic state of the low-carrier density, strongly correlated Kondo lattice system CeSb, from electronic structure calculations and angle-dependent magnetoresistance measurements. When the applied magnetic field is parallel to the electric current, a pronounced negative magnetoresistance is observed within the ferromagnetic state, which is destroyed upon slightly rotating the field away. These results give evidence for CeSb belonging to a new class of Kondo lattice materials with Weyl fermions in the ferromagnetic state.
Social Coordination Information in Dynamic Chase Modulates EEG Mu Rhythm
Authors: Yin Jun , Ding Xiaowei , Xu Haokui , Zhang Feng , Shen Mowei 
Published: June 2017

AbstractUnderstanding actions plays an impressive role in our social life. Such processing has been suggested to be reflected by EEG Mu rhythm (8–13 Hz in sensorimotor regions). However, it remains unclear whether Mu rhythm is modulated by the social nature of coordination information in interactive actions (i.e., inter-dependency). This study used a novel manipulation of social coordination information: in a computer-based task, participants viewed a replay of two chasers chasing a common target coordinately (coordinated chase) or independently (solo chase). Simultaneously, to distinguish the potential effect of social coordination information from that of object-directed goal information, a control version of each condition was created by randomizing one chaser’s movement. In a second experiment, we made the target invisible to participants to control for low-level properties. Watching replays of coordinated chases induced stronger Mu suppression than solo chases, although both involved a common target. These effects were not explained by attention mechanisms or low-level physical patterns (e.g., the degree of physical synchronization). Therefore, the current findings suggest that processing social coordination information can be reflected by Mu rhythm. This function of Mu rhythm may characterize the activity of human mirror neuron system.
Evolutionary dynamics of N-person Hawk-Dove games
Authors: Chen Wei , Gracia-Lázaro Carlos , Li Zhiwu , Wang Long , Moreno Yamir 
Published: June 2017

AbstractIn the animal world, the competition between individuals belonging to different species for a resource often requires the cooperation of several individuals in groups. This paper proposes a generalization of the Hawk-Dove Game for an arbitrary number of agents: the N-person Hawk-Dove Game. In this model, doves exemplify the cooperative behavior without intraspecies conflict, while hawks represent the aggressive behavior. In the absence of hawks, doves share the resource equally and avoid conflict, but having hawks around lead to doves escaping without fighting. Conversely, hawks fight for the resource at the cost of getting injured. Nevertheless, if doves are present in sufficient number to expel the hawks, they can aggregate to protect the resource, and thus avoid being plundered by hawks. We derive and numerically solve an exact equation for the evolution of the system in both finite and infinite well-mixed populations, finding the conditions for stable coexistence between both species. Furthermore, by varying the different parameters, we found a scenario of bifurcations that leads the system from dominating hawks and coexistence to bi-stability, multiple interior equilibria and dominating doves.
Fungus-derived hydroxyl radicals kill hepatic cells by enhancing nuclear transglutaminase
Authors: Shrestha Ronak , Shrestha Rajan , Qin Xian-Yang , Kuo Ting-Fang , Oshima Yugo , Iwatani Shun , Teraoka Ryutaro , Fujii Keisuke , Hara Mitsuko , Li Mengqian , Takahashi-Nakaguchi Azusa , Chibana Hiroji , Lu Jun , Cai Muyi , Kajiwara Susumu , Kojima Soichi 
Published: June 2017

AbstractWe previously reported the importance of induced nuclear transglutaminase (TG) 2 activity, which results in hepatic cell death, in ethanol-induced liver injury. Here, we show that co-incubation of either human hepatic cells or mouse primary hepatocytes derived from wild-type but not TG2−/− mice with pathogenic fungi Candida albicans and C. glabrata, but not baker’s yeast Saccharomyces cerevisiae, induced cell death in host cells by enhancing cellular, particularly nuclear, TG activity. Further pharmacological and genetic approaches demonstrated that this phenomenon was mediated partly by the production of reactive oxygen species (ROS) such as hydroxyl radicals, as detected by a fluorescent probe and electron spin resonance. A ROS scavenger, N-acetyl cysteine, blocked enhanced TG activity primarily in the nuclei and inhibited cell death. In contrast, deletion of C. glabrata nox-1, which encodes a ROS-generating enzyme, resulted in a strain that failed to induce the same phenomena. A similar induction of hepatic ROS and TG activities was observed in C. albicans-infected mice. An antioxidant corn peptide fraction inhibited these phenomena in hepatic cells. These results address the impact of ROS-generating pathogens in inducing nuclear TG2-related liver injuries, which provides novel therapeutic targets for preventing and curing alcoholic liver disease.
Distributed quasi-Bragg beam splitter in crossed atomic waveguides
Authors: Guarrera V. , Moore R. , Bunting A. , Vanderbruggen T. , Ovchinnikov Y. B. 
Published: June 2017

AbstractWe perform an experimental and theoretical study of a novel distributed quasi-Bragg splitter for cold atoms propagating in crossed optical waveguides. The atoms are guided by horizontal red-detuned laser beams which cross with an angle of roughly 90°. The lattice formed by the interference between the two waveguides is used as a quasi-Bragg splitter to continuously deflect the atomic flux from one waveguide into the other. In the limit of strong waveguide confinement and depending on the velocity of the cloud, three main regimes are observed corresponding (1) to the absence of reflection, (2) to partial reflection and (3) to full reflection into the second waveguide. In view of the application to atom interferometry, the condition to split the cloud into mainly two equally-populated fragments is only met in the highest velocity regime, where the fraction of reflected and transmitted atoms can be controlled by tuning the lattice height. A diagnostic of the momentum distribution shows that a quasi-Bragg splitter with the occupation of mainly two momentum states is achieved in this regime. This behaviour can be understood by considering the band structure associated with the potential in the crossing region and agrees with numerical simulations of the atomic dynamics.
Experimental demonstration of robust entanglement distribution over reciprocal noisy channels assisted by a counter-propagating classical reference light
Authors: Ikuta Rikizo , Nozaki Shota , Yamamoto Takashi , Koashi Masato , Imoto Nobuyuki 
Published: June 2017

AbstractEmbedding a quantum state in a decoherence-free subspace (DFS) formed by multiple photons is one of the promising methods for robust entanglement distribution of photonic states over collective noisy channels. In practice, however, such a scheme suffers from a low efficiency proportional to transmittance of the channel to the power of the number of photons forming the DFS. The use of a counter-propagating coherent pulse can improve the efficiency to scale linearly in the channel transmission, but it achieves only protection against phase noises. Recently, it was theoretically proposed [Phys. Rev. A 87, 052325(2013)] that the protection against bit-flip noises can also be achieved if the channel has a reciprocal property. Here we experimentally demonstrate the proposed scheme to distribute polarization-entangled photon pairs against a general collective noise including the bit flip noise and the phase noise. We observed an efficient sharing rate scaling while keeping a high quality of the distributed entangled state. Furthermore, we show that the method is applicable not only to the entanglement distribution but also to the transmission of arbitrary polarization states of a single photon.
Cloning and characterization of the first serine carboxypeptidase from a plant parasitic nematode, Radopholus similis
Authors: Huang Xin , Xu Chun-Ling , Chen Wan-Zhu , Chen Chun , Xie Hui 
Published: June 2017

AbstractRadopholus similis is an important parasitic nematode of plants. Serine carboxypeptidases (SCPs) are peptidases that hydrolyse peptides and proteins and play critical roles in the development, invasion, and pathogenesis of certain parasitic nematodes and other animal pathogens. In this study, we obtained the full-length sequence of the SCP gene from R. similis (Rs-scp-1), which is 1665 bp long and includes a 1461-bp open reading frames encoding 486 amino acids with an 18-aa signal peptide. This gene is a double-copy gene in R. similis. Rs-scp-1 was expressed in the procorpus, esophageal glands and intestines of females and in the esophageal glands and intestines of juveniles. Rs-scp-1 expression levels were highest in females, followed by juveniles and males, and lowest in eggs. Rs-scp-1 expression levels were significantly suppressed after R. similis was soaked in Rs-scp-1 dsRNA for 12 h. Nematodes were then inoculated into Anthurium andraeanum after RNAi treatment. Compared with water treatment, R. similis treated with RNAi were reduced in number and pathogenicity. In summary, we obtained the first SCP gene from a plant parasitic nematode and confirmed its role in the parasitic process.
Prospectively isolated mesenchymal stem/stromal cells are enriched in the CD73+ population and exhibit efficacy after transplantation
Authors: Suto Eriko Grace , Mabuchi Yo , Suzuki Nobuharu , Suzuki Koji , Ogata Yusuke , Taguchi Miyu , Muneta Takeshi , Sekiya Ichiro , Akazawa Chihiro 
Published: June 2017

AbstractMesenchymal stem/stromal cells (MSCs), which reside in the bone marrow (BM) and various other tissues, can self-renew and differentiate into mesenchymal lineages. Many groups have harvested rat MSCs (rMSCs) from rat BM (rBM) by using a flush-out procedure and have evaluated surface marker expression after long-term culture. However, MSCs gradually differentiate during expansion and exhibit altered proliferation rates, morphological features and functions in vitro. Variations in MSC isolation methods may alter the effectiveness of therapeutic applications. Here, on the basis of CD29 (Itgb1) and CD54 (Icam1) expression, we prospectively isolated a population with a high colony-forming ability and multi-lineage potential from the rBM, and we demonstrated that most of these cells expressed CD73. Successful engraftment of rMSCs was achieved by using a fluorescence-conjugated anti-CD73 antibody. In humans and mice, MSCs were also purified by CD73, thus suggesting that CD73 may serve as a universal marker for prospective isolation of MSCs. Our results may facilitate investigations of MSC properties and function.
In-vivo X-ray Dark-Field Chest Radiography of a Pig
Authors: Gromann Lukas B. , De Marco Fabio , Willer Konstantin , Noël Peter B. , Scherer Kai , Renger Bernhard , Gleich Bernhard , Achterhold Klaus , Fingerle Alexander A. , Muenzel Daniela , Auweter Sigrid , Hellbach Katharina , Reiser Maximilian , Baehr Andrea , Dmochewitz Michaela , Schroeter Tobias J. , Koch Frieder J. , Meyer Pascal , Kunka Danays , Mohr Juergen , Yaroshenko Andre , Maack Hanns-Ingo , Pralow Thomas , van der Heijden Hendrik , Proksa Roland , Koehler Thomas , Wieberneit Nataly , Rindt Karsten , Rummeny Ernst J. , Pfeiffer Franz , Herzen Julia 
Published: June 2017

AbstractX-ray chest radiography is an inexpensive and broadly available tool for initial assessment of the lung in clinical routine, but typically lacks diagnostic sensitivity for detection of pulmonary diseases in their early stages. Recent X-ray dark-field (XDF) imaging studies on mice have shown significant improvements in imaging-based lung diagnostics. Especially in the case of early diagnosis of chronic obstructive pulmonary disease (COPD), XDF imaging clearly outperforms conventional radiography. However, a translation of this technique towards the investigation of larger mammals and finally humans has not yet been achieved. In this letter, we present the first in-vivo XDF full-field chest radiographs (32 × 35 cm2) of a living pig, acquired with clinically compatible parameters (40 s scan time, approx. 80 µSv dose). For imaging, we developed a novel high-energy XDF system that overcomes the limitations of currently established setups. Our XDF radiographs yield sufficiently high image quality to enable radiographic evaluation of the lungs. We consider this a milestone in the bench-to-bedside translation of XDF imaging and expect XDF imaging to become an invaluable tool in clinical practice, both as a general chest X-ray modality and as a dedicated tool for high-risk patients affected by smoking, industrial work and indoor cooking.
Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study
Authors: Richard Céline , Courbon Guillaume , Laroche Norbert , Prades Jean Michel , Vico Laurence , Malaval Luc 
Published: June 2017

AbstractLittle is known about middle and inner ear development during the second and third parts of human fetal life. Using ultra-high resolution Microcomputed Tomography coupled with bone histology, we performed the first quantitative middle and inner ear ossification/mineralization evaluation of fetuses between 17 and 39 weeks of gestational age. We show distinct ossification paces between ossicles, with a belated development of the stapes. A complete cochlear bony covering is observed within the time-frame of the onset of hearing, whereas distinct time courses of ossification for semicircular canal envelopes are observed in relation to the start of vestibular functions. The study evidences a spatio-temporal relationship between middle and inner ear structure development and the onset of hearing and balance, critical senses for the fetal adaptation to birth.
Mechanistic action of weak acid drugs on biofilms
Authors: Kundukad Binu , Schussman Megan , Yang Kaiyuan , Seviour Thomas , Yang Liang , Rice Scott A. , Kjelleberg Staffan , Doyle Patrick S. 
Published: June 2017

AbstractSelective permeability of a biofilm matrix to some drugs has resulted in the development of drug tolerant bacteria. Here we studied the efficacy of a weak organic acid drug, N-acetyl-L-cysteine (NAC), on the eradication of biofilms formed by the mucoid strain of Pseudomonas aeruginosa and investigated the commonality of this drug with that of acetic acid. We showed that NAC and acetic acid at pH < pKa can penetrate the matrix and eventually kill 100% of the bacteria embedded in the biofilm. Once the bacteria are killed, the microcolonies swell in size and passively shed bacteria, suggesting that the bacteria act as crosslinkers within the extracellular matrix. Despite shedding of the bacteria, the remnant matrix remains intact and behaves as a pH-responsive hydrogel. These studies not only have implications for drug design but also offer a route to generate robust soft matter materials.