bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and antibiotic susceptibility patterns of uropathogens in men with prostate cancer and benign prostate hyperplasia from Southwestern Nigeria
Authors: Akinpelu Sharon O. , Olasehinde Grace I. , Ikuerowo Stephen O. , Akinnola Olayemi O. 
Published: September 2024

Abstract
Background
Epidemiological investigations have revealed an important association between infection, inflammation and prostate cancer. Certain bacterial species, such as Klebsiella spp, Escherichia coli, Pseudomonas spp, Proteus mirabilis, Chlamydia trachomatis have been linked to prostate cancer. This study aimed to examine the microbiota; specifically bacterial species that have been linked to prostate infections in the urine of individuals diagnosed with prostate cancer.

Results
Sixty-six prostate cancer patients and forty controls provided midstream urine samples. The urine samples were grown on suitable medium, and bacterial isolates were detected by standard microbiological methods. Additionally, the antibiotic sensitivity pattern of the bacterial isolates was analysed. A total of number of 72 bacterial isolates were obtained from the urine of study participants. The results showed the presence of Escherichia coli (50.0%), Pseudomonas aeruginosa (18.1%), Klebsiella spp (15.3%), Staphylococcus aureus (8.3%), Enterobacter spp (4.2%), and Proteus mirabilis (2.8%) in the urine. The most common bacterial species isolated from prostate cancer patients was Escherichia coli, which was susceptible to levofloxacin (100%), tobramycin (91.7%), and amikacin (62.5%).

Conclusions
This study’s findings established the presence of bacteria previously linked to prostatitis. This report indicates a high prevalence of pro-inflammatory bacteria and uropathogens in the urinary tract of men diagnosed with prostate cancer.
Suspected poor-quality medicines in Kenya: a retrospective descriptive study of medicine quality-related complaints reports in Kenya’s pharmacovigilance database
Authors: Toroitich Anthony Martin , Armitage Rachel , Tanna Sangeeta 
Published: September 2024

AbstractPoor-quality, substandard and falsified, medicines pose a significant public health threat, particularly in low-middle-income countries. A retrospective study was performed on Kenya's Pharmacovigilance Electronic Reporting System (2014–2021) to characterize medicine quality-related complaints and identify associations using disproportionality analysis. A total of 2767 individual case safety reports were identified, categorized into medicines with quality defects (52.1%), suspected therapeutic failure (41.6%), and suspected adverse drug reactions (6.3%). Predominantly reported were antineoplastic agents (28.6%), antivirals (11.7%), and antibacterial agents (10.8%) potentially linked to non-adherence to good manufacturing practices, inappropriate usage and supply chain degradation. Notably, analgesics (8.2%), and medical devices (3.5%) notified had quality defects, predominantly from government health facilities (60.0%). Antineoplastic agents (20.2%) and antivirals (3.7%) were frequently reported from suspected therapeutic failures and suspected adverse drug reactions, respectively, across both private for-profit facilities (26.5%) and not-for-profit facilities (5.4%). Underreporting occurred in unlicensed health facilities (8.1%), due to unawareness and reporting challenges. Pharmacists (46.1%), and pharmaceutical technicians (11.7%) predominantly reported quality defects, while medical doctors (28.0%) reported suspected therapeutic failures. Orally administered generic medicines (76.9%) were commonly reported, with tablets (5.8%) identified as potential sources of suspected adverse drug reactions, while quality defects were notified from oral solutions, suspensions, and syrups (7.0%) and medical devices (3.9%). The COVID-19 pandemic correlated with reduced reporting possibly due to prioritization of health surveillance. This study provides valuable evidence to supporting the use of medicine quality-related complaints for proactive, targeted regulatory control of high-risk medicines on the market. This approach can be strengthened by employing standardized terminology to prioritize monitoring of commonly reported suspected poor-quality medicines for risk-based sampling and testing within the supply chain.
Repeated LPS induces training and tolerance of microglial responses across brain regions
Authors: Kim Jennifer , Sullivan Olivia , Lee Kristen , Jao Justin , Tamayo Juan , Madany Abdullah Muhammad , Wong Brandon , Ashwood Paul , Ciernia Annie Vogel 
Published: September 2024

Abstract
Background
Neuroinflammation is involved in the pathogenesis of almost every central nervous system disorder. As the brain’s innate immune cells, microglia fine tune their activity to a dynamic brain environment. Previous studies have shown that repeated bouts of peripheral inflammation can trigger long-term changes in microglial gene expression and function, a form of innate immune memory.

Methods and results
In this study, we used multiple low-dose lipopolysaccharide (LPS) injections in adult mice to study the acute cytokine, transcriptomic, and microglia morphological changes that contribute to the formation of immune memory in the frontal cortex, hippocampus, and striatum, as well as the long-term effects of these changes on behavior. Training and tolerance of gene expression was shared across regions, and we identified 3 unique clusters of DEGs (2xLPS-sensitive, 4xLPS-sensitive, LPS-decreased) enriched for different biological functions. 2xLPS-sensitive DEG promoters were enriched for binding sites for IRF and NFkB family transcription factors, two key regulators of innate immune memory. We quantified shifts in microglia morphological populations and found that while the proportion of ramified and rod-like microglia mostly remained consistent within brain regions and sexes with LPS treatment, there was a shift from ameboid towards hypertrophic morphological states across immune memory states and a dynamic emergence and resolution of events of microglia aligning end-to-end with repeated LPS.

Conclusions
Together, findings support the dynamic regulation of microglia during the formation of immune memories in the brain and support future work to exploit this model in brain disease contexts.
Advanced fine-tuning procedures to enhance DNN robustness in visual coding for machines
Authors: Marie Alban , Desnos Karol , Mercat Alexandre , Morin Luce , Vanne Jarno , Zhang Lu 
Published: September 2024

AbstractVideo Coding for Machines (VCM) is gaining momentum in applications like autonomous driving, industry manufacturing, and surveillance, where the robustness of machine learning algorithms against coding artifacts is one of the key success factors. This work complements the MPEG/JVET standardization efforts in improving the resilience of deep neural network (DNN)-based machine models against such coding artifacts by proposing the following three advanced fine-tuning procedures for their training: (1) the progressive increase of the distortion strength as the training proceeds; (2) the incorporation of a regularization term in the original loss function to minimize the distance between predictions on compressed and original content; and (3) a joint training procedure that combines the proposed two approaches. These proposals were evaluated against a conventional fine-tuning anchor on two different machine tasks and datasets: image classification on ImageNet and semantic segmentation on Cityscapes. Our joint training procedure is shown to reduce the training time in both cases and still obtain a 2.4% coding gain in image classification and 7.4% in semantic segmentation, whereas a slight increase in training time can bring up to 9.4% better coding efficiency for the segmentation. All these coding gains are obtained without any additional inference or encoding time. As these advanced fine-tuning procedures are standard-compliant, they offer the potential to have a significant impact on visual coding for machine applications.
The use of indocyanine green for colorectal anastomoses: a systematic review and meta-analysis
Authors: Borg L , Portelli M , Testa L , Andrejevic P 
Published: September 2024

Introduction Anastomotic leak is a relatively common and debilitating complication. Colorectal leak rates vary widely in the literature, ranging from 1% to 20%. In modern surgical practice, there is much emphasis on the use of indocyanine green (ICG). This is a fluorescent dye administered intravenously to locate and predict an adequate line of anastomosis. We sought to analyse the current literature and supporting evidence behind the use of ICG in the context of elective colorectal surgery. Methods A literature search was conducted for papers published between January 1991 and December 2022 concerning the use of ICG in colorectal surgery. Data on anastomotic leak, overall complication rate, operative time and involvement of artificial intelligence (AI) were compared. Results A total of 24 studies were selected, including 3 randomised controlled trials. There was an anastomotic leak rate of 4.3% in cases with ICG administration compared with 9.5% in the control group (p<0.00001). Seven studies mentioned overall complication rates. These were lower in the ICG cohort than in the control group (15.5% vs 24.5%). There was no significant correlation between ICG use and operative time (p=0.78). Five studies looked at AI, with results suggesting that use of AI leads to much better accuracy in ICG metric analysis. However, the current literature is still inconclusive. Conclusions While there is strong evidence behind ICG use in the existing literature, more randomised controlled trials are required for better recommendations. AI in ICG metric interpretation has proved to be difficult owing to interpatient variability. Nevertheless, new data suggest better understanding and standardisation.
Implications of cyber incident reporting obligations on multinational organizations headquartered in Switzerland
Authors: Ecabert Thomas , Muhly Fabian , Zimmermann Verena 
Published: September 2024

AbstractAs the digital landscape evolves, states are increasingly implementing national cyber incident reporting obligations to enhance cyber resilience. This study investigates the implications of these obligations on multinational organizations, focusing on the variability of compliance requirements across jurisdictions and the challenges faced by companies in adhering to these diverse regulations. Through the methodological approach of conducting interviews with cybersecurity experts across various sectors, this study points out the growing complexity in cybersecurity incident reporting obligations. Findings reveal that companies employ multiple strategies to report to regulators, monitor regulatory changes, and educate employees responsible for reporting. However, maintaining compliance is identified as a significant challenge across all sectors, leading to calls for the standardization of regulations and the improvement of automation solutions. Given the lack of research in this area, this work lays the groundwork for future research, opening new avenues for investigation into the potential standardization and automation of cyber incident reporting processes.
Predictors of self-care in patients with cancer treated with oral anticancer agents: A systematic review
Authors: Ucciero Silvia , Lacarbonara Federica , Durante Angela , Torino Francesco , Uchmanowicz Izabella , Vellone Ercole , Di Nitto Marco 
Published: September 2024

Background
In the last two decades, the use of oral anticancer agents (OAAs) has increased in cancer patients. Despite this, patients and their caregivers face some challenging issues (side effects, drug-to-drug interactions, etc.) related to OAA administration. The three dimensions of self-care by Riegel et al., self-care maintenance (i.e., stability of patient condition), self-care monitoring (i.e., detection of side effects), and self-care management (i.e., management of side effects), may be implemented to avoid negative outcomes. However, knowledge of self-care determinants is necessary to recognise people at risk of poor self-care behaviours.

Aims
Determine which are the predictors of self-care maintenance, self-care monitoring and self-care management in patients with cancer taking OAA.

Methods
A systematic review with narrative synthesis was conducted. We included studies on adult patients with cancer using any kind of oral anticancer agent and describing a predictor of self-care. The search was performed on PubMed, CINAHL/PsycINFO, and Web of Science.

Results
Of 3,061 records, 45 studies were included in this review. Forty-six predictors organised into 14 categories were identified. In general, all studies focused only on adherence, considered as a self-care maintenance component, and none of them focused on other dimensions of self-care. The predictors of OAA adherence most reported were age, side effects, and socioeconomic factors (e.g., insurance status, and annual income).

Conclusions
This systematic review highlighted the literature gap on the analysis of determinants of self-care behaviours in patients taking OAAs. This element could be a starting point for future research that can provide elements to support the oncology nursing research agenda, aimed at recognising patients at risk of poor self-care.
Comparison of the ability of resection versus nonresection surgery to prevent the recurrence of sigmoid volvulus: A protocol of a meta-analysis and systematic review
Authors: Jiang Xiaomei , Du Qiang , Yang Lie 
Published: September 2024

Purpose
Based on clinical research guidelines and clinical practice, patients with sigmoid volvulus (SV) who receive conservative treatment have a greater recurrence rate than patients who do not receive conservative treatment, which is almost without any controversy. Surgical treatment is usually the final treatment for patients with SV. However, there are multiple surgical methods for the treatment of SV, which can be roughly divided into resection and nonresection methods. The available evidence on the effectiveness of surgery for preventing postoperative recurrence is still inadequate. Therefore, we drafted this systematic review protocol with meta-analysis aimed to compare the effects of these two major types of surgery on preventing the recurrence of SV.

Methods
We comprehensively and systematically reviewed the PubMed, EMBASE, MEDLINE and Cochrane Library databases of articles on SV from inception to November 16, 2023. Two independent authors will screen and analyze the detected literature, and disputes will be resolved through communication with a third experienced person. After evaluating the quality of the literature and estimating the risk of bias, we calculate the pooled effect size and 95% confidence interval. Heterogeneity is analyzed by subgroup analysis, and sensitivity analysis can be carried out to assure the reliability of the results. Finally, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) will be used to evaluate the strength of the evidence. The results of each analysis will be recorded in detail. The whole process was carried out in strict accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines (PRISMA-P).

Trial registration
Protocol registration: The study protocol has been registered at the International Prospective Register of Systematic Reviews platform (PROSPERO) (CRD42024508350). Protocol version 1.0, 13 Feb 2024.
Temporal Trend of Incidence and Prevalence of Eosinophilic Esophagitis in Asia: A Systematic Review and Meta-Analysis
Authors: Leung Ryan , Yeung Michelle Leong Ching , Li Yunhao , Muftah Mayssan , Chan Walter W. , Leung Wai K. 
Published: September 2024

INTRODUCTION:
There are limited epidemiological studies on eosinophilic esophagitis (EoE) in Asia. We studied the temporal trend of EoE in Asia, the presenting symptoms, and association with atopic diseases.

METHODS:
Literature search on PubMed, Embase, MEDLINE, Scopus, and Web of Science was performed to retrieve studies published between 1980 and 2023 that reported the prevalence or incidence of EoE in Asia. We used a random-effects model to estimate the pooled incidence and prevalence. I
2 index and Cochran Q test were used to assess heterogeneity. Subgroup analyses were conducted for study types, different regions, years of examination, and age groups. The proportion of atopic diseases among patients with EoE was presented.

RESULTS:
Twenty-five studies from Asia were included. The pooled prevalence of EoE was 33.5 cases per 100,000 inhabitants in population-based studies and 11.0 cases per 1,000 patients/visitors in hospital-based studies. The incidence rate among children was 12.3 cases per 1,000 patients/visitors, whereas for adults, it was only 0.2 cases per 1,000 patients/visitors. Among population-based studies, there was an increase in prevalence from 19.8 per 100,000 individuals in 2005–2009 to 73.0 per 100,000 individuals in 2015–2019. A similar upward trend was observed in hospital-based studies conducted during the same period. Patients with EoE commonly presented with dysphagia (36.3%) and nausea and vomiting (34.6%). History of atopy was reported in 57.2% of patients with EoE in Asia.

DISCUSSION:
The prevalence and incidence of EoE in Asia have been rising over the past decades. Because of the limited number of Asian studies and variations in patient sources, caution should be exercised when interpreting these results.
Anti–Tumor Necrosis Factor Therapy and the Risk of Gestational Diabetes in Pregnant Women With Inflammatory Bowel Disease
Authors: Cho Yongtai , Choi Eun-Young , Choi Ahhyung , Han Jung Yeol , Ye Byong Duk , Kim Ju Hwan , Shin Ju-Young 
Published: September 2024

INTRODUCTION:
Anti–tumor necrosis factor (anti-TNF) therapy may improve insulin sensitivity, and its impact during pregnancy remains unclear. We aimed to assess the risk of gestational diabetes mellitus (GDM) associated with anti-TNF treatment among pregnant women with inflammatory bowel disease (IBD).

METHODS:
This nationwide cohort study included patients with IBD in Korea from 2010 to 2021. Anti-TNF exposure was identified from the last menstrual period (LMP) to LMP + 140 days. The development of GDM was assessed from LMP + 141 days to delivery. We performed overlap weighting to balance the covariates and used a generalized linear mixed model to measure the risk ratio (RR) and 95% confidence intervals (CIs). The anti-TNF group was compared with the unexposed group, as well as with the immunosuppressant, 5-aminosalicylate, and untreated groups.

RESULTS:
A total of 3,695 pregnancies in women with IBD were identified, of which 338 (9.2%) were exposed to anti-TNFs. GDM was found in 7.1% of the pregnancies exposed to anti-TNFs as compared with 11.0% of those unexposed. The crude and weighted RRs for GDM risk were 0.64 (95% CI 0.43–0.96) and 0.68 (95% CI 0.55–0.84), respectively. The weighted RR when compared with the immunosuppressant, 5-aminosalicylate, and untreated groups was 0.70 (95% CI 0.41–1.18), 0.71 (95% CI 0.52–0.95), and 0.85 (95% CI 0.59–1.24), respectively.

DISCUSSION:
This nationwide cohort reported a decreased risk of GDM among patients who used anti-TNFs during early pregnancy compared with those unexposed. GDM risk may become a consideration in the decision-making process when choosing treatment options for pregnant women with a risk factor for GDM.
Relational Processes and Social Projections in Facebook Selfie-Quotation Juxtaposition: An Exploratory Study
Authors: Xiong Yuan , Munalim Leonardo O. 
Published: September 2024

Abstract
The juxtaposition between selfie and quotation is an emerging user-generated Facebook content. This exploratory study is the first to show how Facebook users self-represent themselves through Relational Processes, based on the intertextuality between these verbal and visual modes. Relational Processes refer to the process of characterizing, identifying or describing a person or entity. In this study, 132 Facebook quotations were categorized into three types of Relational Processes based on the users’ selfies. The clauses were restated into I-expressions to center the users’ multimodal experiential and egocentric positioning. The findings revealed that Attributive Relational Processes, such as “I am happy,” predominated in the self-quotation juxtaposition. These relational processes are then discussed based on the potential social projections within the Philippine cultural circuit, namely: the Filipino culture of “inggit” (envy); crab mentality; being social climbers; and the neoliberal and neocolonial status of the Philippines as channeled through the Western-driven quotations. Overall, we argue that the juxtaposition of these two semiotic modes can lead to the creation of a new persona of the Facebook users, enhancing their digital self-remodeling and self-representation.
Removal of methylene blue (MB) and vat dyes from wastewater using nanostructured PANI, PPy, and PTh: a comparative study
Authors: Ahmad Md. Faruak , Rokonujjaman Md. , Hossain Nayem , Das Satu , Rahman Khan Mohammad Mizanur , Jeong Jae-Ho 
Published: September 2024

Abstract
The removal capabilities of organic pollutants methylene blue (MB) and textile dyes, especially the vat dyes from wastewater were reported using polyaniline (PANI), polypyrrole (PPy) and polythiophene (PTh) under direct sunlight irradiation. The comparative removal competence of these polymers is reported in the present work. Among the three polymers, PANI demonstrated nanofiber morphology, PPy showed a spherical-shaped structure, and the agglomerated and irregular morphology for the PTh was appreciated, and investigated by field-emission scanning electron microscopy (FESEM). However, the diameter of the particles remains 20–200 nm for these three polymers. The experimental findings for the photocatalytic performances of all three polymers demonstrated that PANI showed 97 % removal of MB in 660 min whereas, PPy and PTh showed 96  and 94 % removal, respectively. The results for removing vat dyes are 41 % for PANI, 44 % for PPy, and 45 % for PTh. Thus, PANI, PPy, and PTh are able to remove both MB and vat dyes, however the % of vat dyes removal is lower compared to MB. These outcomes may provide a new perception of conducting polymers as photocatalysts for organic dye removal in water purifications.
Multiple translation and the translator’s visibility
Authors: Agnetta Marco 
Published: September 2024

Abstract
This essay proposes to show how translation plurality, i. e. the existence of several translations of the same original, ensures the translation’s and the translator’s visibility. The starting point is Venuti’s concepts of ‘fluent translation’ or the ‘transparency’ of translation, coined for English-language translation practice between 1700 and today, and his – centuries old – distinction between domestication and foreignization. On the basis of Melchiorre Cesarotti’s project of a double Italian translation of the Iliad and, in particular, his theoretical reflections on translation, it is argued that translation plurality is one way to overcome the notion of only one fluent and transparent leading translation that is criticized by Venuti. The essay concludes with some remarks on building awareness of multiple translations, and on elaborating a general discourse of translation plurality.