bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spinal Fbxo3-Dependent Fbxl2 Ubiquitination of Active Zone Protein RIM1α Mediates Neuropathic Allodynia through CaV2.2 Activation
Authors: Lai Cheng-Yuan , Ho Yu-Cheng , Hsieh Ming-Chun , Wang Hsueh-Hsiao , Cheng Jen-Kun , Chau Yat-Pang , Peng Hsien-Yu 
Published: September 2016

Spinal plasticity, a key process mediating neuropathic pain development, requires ubiquitination-dependent protein turnover. Presynaptic active zone proteins have a crucial role in regulating vesicle exocytosis, which is essential for synaptic plasticity. Nevertheless, the mechanism for ubiquitination-regulated turnover of presynaptic active zone proteins in the progression of spinal plasticity-associated neuropathic pain remains unclear. Here, after research involving Sprague Dawley rats, we reported that spinal nerve ligation (SNL), in addition to causing allodynia, enhances the Rab3-interactive molecule-1α (RIM1α), a major active zone protein presumed to regulate neural plasticity, specifically in the synaptic plasma membranes (SPMs) of the ipsilateral dorsal horn. Spinal RIM1α-associated allodynia was mediated by Fbxo3, which abates Fbxl2-dependent RIM1α ubiquitination. Subsequently, following deubiquitination, enhanced RIM1α directly binds to CaV2.2, resulting in increased CaV2.2 expression in the SPMs of the dorsal horn. While exhibiting no effect on Fbxo3/Fbxl2 signaling, the focal knockdown of spinal RIM1α expression reversed the SNL-induced allodynia and increased spontaneous EPSC (sEPSC) frequency by suppressing RIM1α-facilitated CaV2.2 expression in the dorsal horn. Intrathecal applications of BC-1215 (a Fbxo3 activity inhibitor), Fbxl2 mRNA-targeting small-interfering RNA, and ω-conotoxin GVIA (a CaV2.2 blocker) attenuated RIM1α upregulation, enhanced RIM1α expression, and exhibited no effect on RIM1α expression, respectively. These results confirm the prediction that spinal presynaptic Fbxo3-dependent Fbxl2 ubiquitination promotes the subsequent RIM1α/CaV2.2 cascade in SNL-induced neuropathic pain. Our findings identify a role of the presynaptic active zone protein in pain-associated plasticity. That is, RIM1α-facilitated CaV2.2 expression plays a role in the downstream signaling of Fbxo3-dependent Fbxl2 ubiquitination/degradation to promote spinal plasticity underlying the progression of nociceptive hypersensitivity following neuropathic injury.SIGNIFICANCE STATEMENTUbiquitination is a well known process required for protein degradation. Studies investigating pain pathology have demonstrated that ubiquitination contributes to chronic pain by regulating the turnover of synaptic proteins. Here, we found that the spinal presynaptic active zone protein Rab3-interactive molecule-1α (RIM1α) participates in neuropathic pain development by binding to and upregulating the expression of CaV2.2. In addition, Fbxo3 modifies this pathway by inhibiting Fbxl2-mediated RIM1α ubiquitination, suggesting that presynaptic protein ubiquitination makes a crucial contribution to the development of neuropathic pain. Research in this area, now in its infancy, could potentially provide a novel therapeutic strategy for pain relief.
Atuação Fisioterapêutica no Transplante Hepático: Revisão Bibliográfica Narrativa e Integrativa
Authors: Prudente Geisyani Francisca Gomes , Pessoa Guilherme Da Silva , Ferreira Samya Rebeca Rocha , Nunesa Natália Paz , Bravo Lorena Guedes , Macena Raimunda Hermelinda Maia , Campos Maria Flávia Amâncio , Nogueira Andréa Da Nóbrega Cirino , De Vasconcelos Thiago Brasileiro 
Published: September 2016

<p>O transplante é uma intervenção terapêutica utilizada no tratamento de indivíduos com doenças terminais do fígado. Os pacientes candidatos ao<br />transplante geralmente já apresentam alteração da função hepática que, associada ao procedimento cirúrgico, pode provocar sérias modificações da funcionalidade, em especial as cardiorrespiratórias. A Fisioterapia tem papel importante no pré e pós-operatório de transplante de fígado, tendo em vista à preservação da funcionalidade e o retorno precoce as atividades laborais e pessoais. Este estudo realizou uma revisão bibliográfica narrativa e integrativa sobre a atuação fisioterapêutica no transplante hepático. Foi realizado um levantamento nas bases virtuais de dados eletrônicas, Bireme (MedLine e Lilacs), nas línguas portuguesa e inglesa, utilizando como palavra-chave “transplante hepático”, utilizada de forma isolada ou em associação com o descritor “fisioterapia”. Foram encontrados 598 artigos. Somente 3 atenderam aos critérios de inclusão. Embora a Fisioterapia seja de extrema importância nos casos de transplante hepático, poucos são os estudos publicados relacionados ao tema, sugerindo a necessidade premente de mais pesquisas na área.</p>
ESCRAVIDÃO E(M) QUADRINHOS: UM DIÁLOGO ENTRE A HISTORIOGRAFIA E A CULTURA HISTÓRICA DAS HQ’s * SLAVERY AND COMIC BOOKS: A DIALOGUE BETWEEN HISTORIOGRAPHY AND HISTORICAL CULTURE OF COMICS
Authors: Lima Hezrom Vieira Costa 
Published: September 2016

Resumo: As Histórias em Quadrinhos (HQs) são meios de comunicação amplamente difundidos em nível nacional. Como todo e qualquer produto cultural, seus autores estão inseridos em sociedades que apresentam contradições e embates, os quais são reproduzidos em suas obras. Diante desse contexto, o presente trabalho tem por objetivo analisar a cultura histórica na HQ “O quilombo Orum Aiê” de André Diniz, a partir dos pressupostos teóricos de Rüsen (2001) e Flores (2007), percebendo como as HQs, produções culturais que estão à parte do cânone historiográfico e da historiografia, repercutem as opções teóricas e metodológicas da “Nova História Social da Escravidão”, iniciada no Brasil após a década de 1980. Ademais, a análise foi realizada demonstrando de que forma a historiografia é refletida nas Histórias em Quadrinhos nacionais que abordam a temática da escravidão. Palavras-chave: Cultura Histórica. História em Quadrinhos. Historiografia. Escravidão. Abstract: The Comics Books (Comics) are media widey disseminated nationally. As any cultural product, its authors are embedded in societies with contradictions and conflicts, wich are reproduce in this Works. In this sense, this papper aims to analyze the historical culture in comics, from the theoretical assumptions of Rüsen (2001) and Flores (2007), echo theoretical and methodological options of the New Social History of Slavery, started in Brazil after the 1980s the analysis was perfomed demonstrating how historiography is reflected in the sotires in national comics thad adress the issue of slavery.Keywords: Historical Culture. Comics Books. Historiography. Slavery.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS MULTIMEDIA INTERAKTIF UNTUK MEMFASILITASI BELAJAR MANDIRI MAHASISWA PADA MATA KULIAH KAPITA SELEKTA MATEMATIKA
Authors: Wardani Sri , Mudzalipah Ipah , Hidayat Edi 
Published: September 2016

Kemampuan pemahaman dan pemecahan masalah matematik merupakan kemampuan mahasiswa yang perlu dikembangkan di program studi pendidikan matematika. Kemampuan ini termasuk kemampuan berpikir tingkat tinggi yang perlu digali agar mahasiswa mampu berpikir secara rasional, logis, sistematis, kritis dan kreatif. Aplikasi multimedia pembelajaran matematika dapat menyajikan konsep dan keterampilan tingkat tinggi dalam matematika, yang memiliki keterkaitan antara satu unsur dan unsur lainnya yang sulit diajarkan dan dipelajari melalui buku semata. Kelebihan aplikasi multimedia interaktif matematika adalah dalam menjelaskan suatu konsep dapat menuntut mahasiswa bereksplorasi dan menganalisis, mencoba dan menggali konsep serta prinsip yang termuat dalam suatu materi yang dihadapinya, sehingga dapat membangun struktur pemahamannya. Hal ini dapat terjadi dari terintegrasinya komponen-komponen seperti suara, teks, animasi, gambar/grafik, dan video yang berfungsi untuk mengoptimalkan peran indera dalam menerima informasi ke dalam sistem memori. Saat mahasiswa mengaplikasikan program ini ia diajak untuk terlibat secara auditif, visual dan kinetik sehingga dengan pelibatan ini, informasi atau pesannya mudah dimengerti. Pengembangan media pembelajaran berbasis multimedia interaktif dapat memfasilitasi mahasiswa untuk belajar mandiri dalam mengembangkan kemampuan pemahaman dan pemecahan masalah matematiknya.Kata Kunci: kemampuan pemahaman matematik, kemandirian belajar, pembelajaran multimedia interaktif, pemecahan masalah matematik
MODEL PEMBELAJARAN SIKLUS BELAJAR DESKRIPTIF UNTUK MENINGKATKAN PEMAHAMAN KONSEP DAN KETERAMPILAN BERPIKIR KRITIS SISWA SMK PADA MATERI IKATAN KIMIA
Authors: Mulyasih Suhaeti Sri 
Published: September 2016

The aim of this study was to get information about the effectiveness of using descriptive learning cycle instructional model to improve students’ understanding and critical thinking skills related to chemical bonding concept in one of vocational high schools (SMK) in Sumedang. Indicators for conceptual understanding consisted of six categories, while indicators of critical thinking skills were four indicators. The method used was quasi-experimental research design nonequivalent pretest-posttest control group design. Instrument used was essay test. T test results showed that based on the average value of n-gain, difference in overall students' conceptual understanding in experimental class and control class was significant (p = 0.00 p <0.05), and critical thinking skills significantly developed by descriptive learning model cycle was to identify conclusions (p = 0.004 p <0.05).Keywords: critical thinking skills, concepts of chemical bonding, descriptive learning model, understanding conceptsABSTRAK Penelitian ini bertujuan untuk memperoleh informasi mengenai penggunaan model pembelajaran siklus belajar deskriptif dalam upaya meningkatkan pemahaman konsep dan berpikir kritis siswa di salah satu SMK di Kabupaten Sumedang pada konsep ikatan kimia. Indikator pemahaman konsep yang diselidiki terdiri dari enam kategori, sedangkan indikator keterampilan berpikir kritis yang diselidiki berjumlah empat indikator. Metode penelitian yang digunakan adalah kuasi eksperimen dengan desain penelitian nonequivalent pretest-posttest control group design. Instrumen yang digunakan berupa soal tes berbentuk esai. Hasil uji t menunjukkan bahwa berdasarkan nilai rata-rata n-gain, perbedaan pemahaman konsep siswa antara kelas eksperimen dan kelas kontrol secara keseluruhan berbeda signifikan (p= 0,00 p< 0,05), dan keterampilan berpikir kritis yang paling dapat dikembangkan secara signifikan melalui model pembelajaran siklus belajar deskriptif adalah mengidentifikasi kesimpulan (p= 0,004 p< 0,05).Kata kunci: model pembelajaran deskriptif, pemahaman konsep, keterampilan berpikir kritis, konsep ikatan kimia
MENINGKATKAN DAYA TANGGAP DAN HASIL BELAJAR IPA SISWA SMP DI KELAS KHUSUS OLAH RAGA MELALUI MEDIA PEMBELAJARAN ANIMASI
Authors: Kurniasih Tjitjih , Haryani Mrs. , Ciptowati Endang 
Published: September 2016

This research aimed to increase students’ response towards science learning and science learning outcome in sport class using animation learning media. Through this research, it was expected that students’ response during teaching and learning activities would increased and students’ will be interested in doing these activities so that it will increase their science learning outcome. This research was three cycles-class action research in which every cycles consists of four stages. Research subjects was 36, 8th grader students (sports class) in one of junior high school in Bogor. Research instruments were students’ responsiveness evaluation sheet, learning activities observation sheet, and learning results instrument (postest question). The collected data were analyzed its average. In first cycle, learning outcome was 42% whereas students’ responsiveness was 56% (low). In cycle 2, learning outcome and students’ responsiveness were increased to 72% and 68%, respectively. In cycle 3, clasical completedness of 88% for learning outcome and 93% for students’ responsiveness (beyond clasical completedness standard) were achieved. Results suggested that animation learning media may increased students’ responsiveness and learning outcome of science subjects in sports class.Keywords: students’ responsiveness, science learning outcome, sport class, animation learning media.ABSTRAKPenelitian ini bertujuan untuk meningkatkan daya tanggap siswa dan hasil belajar IPA di kelas khusus olah raga dengan menggunakan media pembelajaran animasi. Melalui penelitian ini diharapkan bahwa tanggapan siswa selama Kegiatan Belajar Mengajar akan meningkat dan kegiatan belajar IPA menjadi menyenangkan sehingga akhirnya dapat meningkatkan hasil belajar IPA. Penelitian ini merupakan Penelitian Tindakan Kelas tiga siklus. Setiap siklus terdiri dari empat tahap. Subjek penelitian adalah 36 siswa kelas VIII (kelas khusus olahraga) di salah satu SMP Negeri di Bogor. Instrumen penelitian yang digunakan adalah lembar observasi daya tanggap siswa selama KBM, lembar observasi kegiatan pembelajaran, dan instrumen hasil belajar (soal postes). Data yang dihasilkan kemudian dianalisis nilai rata-ratanya. Pada siklus pertama hasil belajar mencapai 42% dan daya tanggap siswa terhadap aktivitas guru dalam KBM hanya 56% (kurang). Pada siklus 2 hasil belajar mencapai 72% dan daya tanggap siswa terhadap aktivitas guru dalam KBM naik menjadi 68%. Pada siklus 3 hasil belajar IPA kelas khusus olahraga akhirnya mencapai ketuntasan klasikal 88% dan daya tanggap terhadap aktivitas guru dalam KBM mencapai 93% (melampaui standar ketuntasan klasikal). Hasil penelitian ini menunjukkan bahwa media pembelajaran animasi dapat meningkatkan daya tanggap dan hasil belajar IPA kelas khusus olahraga.Kata kunci: daya tanggap siswa, Hasil belajar IPA, Kelas Khusus Olah Raga, Media Pembelajaran Animasi.
STRATEGI PEMBELAJARAN METAKOGNITIF TERHADAP HASIL BELAJAR SISWA PADA KONSEP SISTEM PENCERNAAN PADA MANUSIA
Authors: Khoiriah Tuti 
Published: September 2016

This study aims to determine the effect of metacognitive learning strategies on student learning outcomes in the concept of the human digestive system. This study was conducted in one of the SMA in Tangerang. The method used was a quasi-experimental design using pretest-posttest control group design. Samples were students of class XI IPA-4 totaling 35 people as classroom control and class XI IPA-1 experiment class. Instruments used were multiple choice tests, students worksheets and student learning activity observation sheet. Results showed that there were significant differences in learning outcomes between classes to learn metacognitive strategies to control class (tvalue= 2.19 and t table 2.03, tvalue> ttabel.)Keywords: Human Digestive System, Learning Result , Metacognitive Learning StrategyABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh strategi belajar metakognitif terhadap hasil belajar siswa pada konsep sistem pencernaan pada manusia. Penelitian ini dilakukan pada bulan Januari 2015 di salah satu Sekolah Menengah Atas di Tangerang. Metode yang digunakan adalah kuasi eksperimen yang menggunakan desain pretest-posttest control group design. Pengambilan sampel dalam penelitian ini menggunakan teknik random sampling. Sampel penelitian ini adalah siswa kelas XI IPA 4 berjumlah 35 orang sebagai kelas kontrol dan kelas XI IPA 1 berjumlah 35 orang sebagai kelas eksperimen. Instrumen yang digunakan berupa tes yang berbentuk pilihan ganda dan nontes berupa lembar kerja siswa dan lembar observasi aktivitas belajar siswa. Hasil menunjukkan bahwa terdapat perbedaan hasil belajar yang signifikan antara kelas dengan strategi belajar metakognitif dengan kelas kontrol (thitung 2,19 dan ttabel 2,03, thitung > ttabel.)Kata kunci: Hasil belajar, Sistem Pencernaan pada Manusia, Strategi belajar metakognitif
HEAT DIFFUSION IN TWO-DIMENSIONAL MEDIA CONTAINING SMALL-SCALL CRACK
Authors: Kusnandi Mr 
Published: September 2016

Dalam artikel ini, kita mempelajari difusi panas dalam media berdimensi dua yang memuat crack. Ada dua jenis crack yang kita pandang, crack lentur dan crack keras. Kedua jenis crack itu dibedakan oleh syarat batas dari persamaan difusi. Dengan menggunakan metode dari Muijres, kita dapat menentukan temperatur di luar crack yang dinyatakan dalam fungsi Green dari persamaan difusi dan temperatur incident pada crack. Key words: crack, diffusion, incident field, scattered field
KONSEPSI CALON GURU BIOLOGI TENTANG IPA, BELAJAR, DAN MENGAJAR (CONCEPTION OF BIOLOGY STUDENT TEACHERS’ ABOUT SCIENCE, LEARNING, AND TEACHING)
Authors: Rustaman Nuryani Y , Widodo Ari 
Published: September 2016

A study for one semester in Teaching learning strategy course was carried out to get the profile of biology student teachers conception about science, learning, and science teaching, as we know that constructivist paradigm in education is not just studied as a theory, but needs to be implemented in real teaching learning processes. A number of Biology education students (n =29) were involved as subjects. Their free essay were used as source and were organized through coding and then recoding using specific program (NUD.IST). It was found that there are five categories for their conception about science (i.e. study about nature, collection of knowledge or concepts, research method, the single truth, to worship their Creator); five categories their conception about learning (i.e. changing process, knowledge improvement, conceptual change, thinking process, interaction with environment); and three catagories for their conception about science teaching (i.e. as fasilitating, knowledge transfer, interaction between teacher and students). Most of biology students have more than one conception (two or three), but none of them has a complete conception about science, learning and science teaching. Biology student teachers conception about teaching (mostly as knowledge transfer) is paralel with their conception about science (mostly as study about nature) and about learning (mostly as knowledge improvement). These findings give implication to their supervisor to pay attention more seriously on the students conception abot science, learning, and teaching. Because the way they teach will be influenced by their conception about those things. One suggestion to handle is by giving the student teachers to express their opinion about those things so that they are aware to other conceptions and in turn they will be aware to accept (and apply) conception based on constructivist reference or paradigm.Keywords: conception, student teacher, science, learning, teaching.
METODE KONSTRUKSI UNTUK MENYELESAIKAN MASALAH TATA LETAK FASILITAS
Authors: Kusumah Yaya S. 
Published: September 2016

The facility layout design problem is concerned with determining the location of a number of facilities which optimises a prescribed objective such as profit, cost, or distance. This problem arises in many applications; for example, in design of buildings and in plant layout design. Most approaches for solving this problem are heuristic in nature and based on graph theoretic concepts. Graph theoretically, when the objective is to maximize profit, the facility layout design problem is to determine, in a given edge weighted graph G, a maximum weight planar sub graph. In this paper, a new heuristic based on graph theoretic concepts is presented. A comparative analysis based on 3600 random test problems demonstrates the value of this algorithm. Key words: Heuristic, maximum planar graph, computer, facility layout design.
EFEKTIVITAS PERTANYAAN PENGARAH TERHADAP PENGUASAAN KONSEP DAN RETENSI SISWA DALAM PEMBELAJARAN BIOLOGI
Authors: Rahman Taufik , Rochintaniawati Diana 
Published: September 2016

Questioning plays an important role in teaching learning process. The effect of prompting question and non-prompting question in biology teaching learning process on increasing student’s understanding and student’s retention was evaluated in this study. The method used in the study was experimental involving students in control group who used student experiment and non-experiment worksheet without prompting question and students in experimental group who used student experiment and non-experiment worksheet with prompting question. The study was carried out in 4 concepts, i.e. the environment sustainability, water pollution, environment study, as well as sight organ in Invertebrate. To evaluate the different effect of student worksheet with prompting question and student worksheet without prompting question on increasing student’s understanding and retention posttest 1 and post-test 2 was given to the two groups in time interval of 2,3 and 4 weeks. From the result of the two tests the retention was measured. The study revealed that in the concept of Environment sustainability, environmental study and water pollution the use of student worksheet with prompting question as well as without prompting question was effectively increased student’s understanding to the concept, and the increasing of student’s understanding to the concept between control and experiment group was equally the same. Meanwhile in the concept of the organ sight in invertebrate the use of experiment student worksheet with prompting question more effectively increased student’s understanding to the concept than the use of experiment student worksheet without prompting question. Student in the experiment group performed better retention on the concept than student in control group.
Morphological Transformation of Giant-Cell Tumor of Bone After Treatment with Denosumab
Authors: Zhang Yaxia , Ilaslan Hakan , Krishnaney Ajit A. , Bauer Thomas W. 
Published: September 2016

Case:
Denosumab, an inhibitor of RANKL (receptor activator of nuclear factor κ-B ligand), was recently introduced for the treatment of giant-cell tumor of bone (GCTB). We describe the clinical, radiographic, and histological features of a GCTB of the spine in a 24-year-old woman that progressed after neoadjuvant treatment with denosumab. Disappearance of the multinuclear osteoclastic giant cells was accompanied by newly formed woven bone, which was deposited in interconnected strands with a prominent fibrovascular stroma that was histologically and radiographically similar to that of an osteoblastoma.

Conclusion:
Pathologists, radiologists, and surgeons should be aware of this post-treatment transformation to avoid misdiagnosis.
Customer satisfaction and loyalty factors of Mobile Commerce among young retail customers in Croatia
Authors: Dužević Ines , Delić Mia , Knežević Blaženka 
Published: September 2016

Mobile technology has begun to transform the way young retail consumers shop, allowing them more intermediate control over purchasing process. With competition accelerating in retail industry, mobile devices have been used widely in delivering value-added services. Hence, mobile commerce is likely to make a strong influence on business activities, consumer behavior, as well as national and global markets. The purpose of this paper is to identify key factors influencing customer satisfaction and loyalty in mobile commerce by empirically-based research questionnaire. Based on previous literature, the paper builds sets of customer satisfaction and loyalty constructs for mobile commerce. Significant constructs and their relationships are examined by m-commerce satisfaction model employing structural equation model. Research findings indicate that all constructs significantly affect Smartphone customers’ satisfaction, except for the price. Furthermore, satisfaction has moderately strong influence on Smartphone customer’ loyalty. The implication of this research to researchers and practitioners is discussed.