bluuebunny/crossref_metadata_2025_split huggingface dataset:
Waffle production: influence of batter ingredients on sticking of fresh egg waffles at baking plates—Part I: effect of starch and sugar components
Authors: Huber Regina , Schoenlechner Regine 
Published: September 2016

AbstractFresh egg waffles are a sweet convenience product typically baked from eggs, water, sugar, flour, fat, leavening agents, emulsifiers, preservatives, and flavors. In industrial production, waffles are baked continuously in high amounts of up to 200 kg raw material per hour. Therefore, it is important that the waffles do not stick onto the baking plates, which can cause significant product loss and increased costs due to interruption of the baking process, required cleaning procedures, and restarting of the energy‐consuming start‐up phase. Sticking of waffles is greatly influenced not only by baking plate material, release agent, baking temperature, and time, but also by the batter ingredients. In this study, effects of different starches and sugar components were investigated. Within the selected starches, potato starch demonstrated the highest effects on increasing waffle stability and releasing properties compared to wheat and lupine flour (less than 7% sticking waffles). Rice flour performed worst, with almost 50% of sticking waffles. Most of these waffles were broken during take‐off, due to their crumbly texture. Within the sugar components, glycerine was better suitable than sorbitol and crystal sugar was superior compared to powdered sugar. They required less take‐off force. It could be demonstrated that waffles with increased stability and texture were those that showed the least number of sticking waffles, thus the main aim of batter ingredients was to improve waffle quality. Waffle quality was influenced by batter parameters, significant correlations could be found, for example, a positive correlation between pH‐ and L‐value, negative correlations between pH‐ and a‐value, or density and aw‐value. This resulted in significant correlations with take‐off‐force, which was correlated with L*‐ and b*‐value (negative) and positive to a*‐value. Sticking behavior was strongly associated with b*‐value (positive) and to a*‐value (negative).
Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder
Authors: Thome Janine , Densmore Maria , Frewen Paul A. , McKinnon Margaret C. , Théberge Jean , Nicholson Andrew A. , Koenig Julian , Thayer Julian F. , Lanius Ruth A. 
Published: September 2016

AbstractObjectivesAlthough dysfunctional emotion regulatory capacities are increasingly recognized as contributing to posttraumatic stress disorder (PTSD), little work has sought to identify biological markers of this vulnerability. Heart rate variability (HRV) is a promising biomarker that, together with neuroimaging, may assist in gaining a deeper understanding of emotion dysregulation in PTSD. The objective of the present study was, therefore, to characterize autonomic response patterns, and their related neuronal patterns in individuals with PTSD at rest.MethodsPTSD patients (N = 57) and healthy controls (N = 41) underwent resting‐state fMRI. Connectivity patterns of key regions within the central autonomic network (CAN)—including the ventromedial prefrontal cortex (vmPFC), amygdala, and periaqueductal gray (PAG)—were examined using a seed‐based approach. Observed connectivity patterns were then correlated to resting HRV.ResultsIn contrast to controls, individuals with PTSD exhibited lower HRV. In addition, whereas controls engaged a localized connectivity pattern of CAN‐related brain regions, in PTSD, key CAN regions were associated with widespread connectivity patterns in regions related to emotional reactivity (vmPFC and amygdala to insular cortex and lentiform nucleus; PAG to insula) and motor readiness (vmPFC and amygdala to precentral gyrus; PAG to precentral gyrus and cerebellum). Critically, whereas CAN connectivity in controls was strongly related to higher HRV (insula, mPFC, superior frontal cortex, thalamus), HRV covariation was absent in PTSD subjects.ConclusionsThis study provides the first evidence for a specific psychophysiological–neuronal profile in PTSD individuals characterized by lower resting HRV and a lack of HRV covariation with CAN‐related brain connectivity. Hum Brain Mapp 38:27–40, 2017. © 2016 Wiley Periodicals, Inc.
AHNS series – Do you know your guidelines? Diagnosis and management of cutaneous squamous cell carcinoma
Authors: Ow Thomas J. , Wang Heng Rui , McLellan Beth , Ciocon David , Amin Bijal , Goldenberg David , Schmalbach Cecelia E. ,   The Education Committee of the American Head and Neck Society (AHNS)
Published: September 2016

AbstractThis article is the next installment of the series “Do You Know Your Guidelines” presented by the Education Committee of the American Head and Neck Society. Guidelines for the prevention, diagnosis, workup, and management of cutaneous squamous cell carcinoma (SCC) are reviewed. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1708–1716, 2016
A phase I/Ib trial targeting the Pi3k/Akt pathway using perifosine: Long‐term progression‐free survival of patients with resistant neuroblastoma
Authors: Kushner Brian H. , Cheung Nai‐Kong V. , Modak Shakeel , Becher Oren J. , Basu Ellen M. , Roberts Stephen S. , Kramer Kim , Dunkel Ira J. 
Published: September 2016

AKT plays a pivotal role in driving the malignant phenotype of many cancers, including high‐risk neuroblastoma (HR‐NB). AKT signaling, however, is active in normal tissues, raising concern about excessive toxicity from its suppression. The oral AKT inhibitor perifosine showed tolerable toxicity in adults and in our phase I trial in children with solid tumors (clinicaltrials.gov NCT00776867). We now report on the HR‐NB experience. HR‐NB patients received perifosine 50–75 mg m−2 day−1 after a loading dose of 100–200 mg m−2 on day 1, and continued on study until progressive disease. The 27 HR‐NB patients included three treated for primary refractory disease and 24 with disease resistant to salvage therapy after 1–5 (median 2) relapses; only one had MYCN‐amplified HR‐NB. Pharmacokinetic studies showed μM concentrations consistent with cytotoxic levels in preclinical models. Nine patients (all MYCN‐non‐amplified) remained progression‐free through 43+ to 74+ (median 54+) months from study entry, including the sole patient to show a complete response and eight patients who had persistence of abnormal 123I‐metaiodobenzylguanidine skeletal uptake but never developed progressive disease. Toxicity was negligible in all 27 patients, even with the prolonged treatment (11–62 months, median 38) in the nine long‐term progression‐free survivors. The clinical findings (i) confirm the safety of therapeutic serum levels of an AKT inhibitor in children; (ii) support perifosine for MYCN‐non‐amplified HR‐NB as monotherapy after completion of standard treatment or combined with other agents (based on preclinical studies) to maximize antitumor effects; and (iii) highlight the welcome possibility that refractory or relapsed MYCN‐non‐amplified HR‐NB is potentially curable.
DDR2–CYR61–MMP1 Signaling Pathway Promotes Bone Erosion in Rheumatoid Arthritis Through Regulating Migration and Invasion of Fibroblast-Like Synoviocytes
Authors: Huang Tong-Lie , Mu Nan , Gu Jin-Tao , Shu Zhen , Zhang Kuo , Zhao Jin-Kang , Zhang Cun , Hao Qiang , Li Wei-Na , Zhang Wang-Qian , Liu Nan-Nan , Zhang Yong , Zhang Wei , Xue Xiao-Chang , Zhang Ying-Qi 
Published: September 2016

ABSTRACT

Regulation of matrix metalloproteinases (MMPs) by collagen in the fibroblast-like synoviocytes (FLSs) plays a critical role in joint destruction in rheumatoid arthritis (RA). Our previous study indicated that discoidin receptor 2 (DDR2) mediated collagen upregulation of MMPs. However, the precise underlying mechanism remains unclear. We report here that CYR61, a secreted, extracellular matrix–associated signaling protein which is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, and apoptosis, is significantly upregulated in collagen II–stimulated RA FLS. Further studies found that collagen II–activated phosphorylated-DDR2 induces CYR61 through activation of transcription factor activator protein 1 (AP-1). The elevated CYR61, in turn, accelerates MMP1 production via ETS1 (ETS proto-oncogene 1). In addition, CYR61 significantly promotes FLS invasion and migration. Blockade of CYR61 by an adenovirus expressing CYR61 shRNA (Ad-shCYR61) in vivo remarkably ameliorated the severity of arthritis, reduced inflammatory cytokine secretion, and attenuated bone erosion as detected by micro–computed tomography (μCT), in collagen-induced arthritis (CIA) rats. Taken together, we uncovered the Collagen II–DDR2–AP-1–CYR61–ETS1–MMP1 loop in RA FLS. In which, CYR61 acts as a hinge to promote cartilage damage through regulating FLS invasion, migration, and MMP1 production and the inflammatory cascade in RA. Thus, CYR61 may be a promising diagnostic and therapeutic target for RA treatment. © 2016 American Society for Bone and Mineral Research.
On Flag‐Transitive Symmetric Designs of Affine Type
Authors: Biliotti Mauro , Montinaro Alessandro 
Published: September 2016

AbstractIt is shown that, if is a nontrivial 2‐ symmetric design, with , admitting a flag‐transitive automorphism group G of affine type, then , p an odd prime, and G is a point‐primitive, block‐primitive subgroup of . Moreover, acts flag‐transitively, point‐primitively on , and is isomorphic to the development of a difference set whose parameters and structure are also provided.
‘Effects of novel root repair materials on attachment and morphological behaviour of periodontal ligament fibroblasts: Scanning electron microscopy observation’
Authors: Akbulut Makbule Bilge , Uyar Arpaci Pembegul , Unverdi Eldeniz Ayce 
Published: September 2016

AbstractThe aim of this study was to evaluate the adhesion of periodontal ligament fibroblasts (PDLs) on newly proposed root repair materials [Biodentine, MM‐MTA, polymethylmethacrylate (PMMA) bone cement, and SDR], in comparison with contemporary root repair materials [IRM, Dyract compomer, ProRoot MTA (PMTA), and Vitrebond]. Five discs from each material were fabricated in sterile Teflon molds, and the specimens were aged and prewetted in cell culture media for 96 hours. Three material discs were used for scanning electron microscopy (SEM) for the assessment of the attachment, density, and morphological changes in the PDLs, while two samples were used for energy dispersive x‐ray spectroscopy (SEM‐EDX) to determine the elemental composition of the materials. Human PDLs were plated onto the materials at a density of 10,000/well, and incubated for 3 days. The SEM micrographs were taken at different magnifications (500× and 5000×). In the SEM, the cells were attached and well spread‐out on the surfaces of the Biodentine, PMTA, and Dyract compomer, while varied cell densities and morphological alterations were observed in the Vitrebond, IRM, MM‐MTA, SDR, and PMMA bone cement groups. The SEM‐EDX analysis revealed a maximum calcium percentage in the PMTA specimens, as well a maximum silicon percentage in the Dyract compomer specimens. This in vitro study demonstrated that the Biodentine and Dyract compomer supported PDL cell adhesion and spreading. The PMTA presented a favorable scaffold for better attachment of the PDL cell aggregates. Therefore, the calcium and silicon content of a material may enhance the PDL cell attachment.
The Effects of Feeding on Cardiac Control of the Broad‐Nosed Caiman (Caiman latirostris): The Role of the Autonomic Nervous System and NANC Factors
Authors: Braga Victor Hugo Da Silva , Armelin Vinicius Araújo , Teixeira Mariana Teodoro , Abe Augusto Shinya , Rantin Francisco Tadeu , Florindo Luiz Henrique 
Published: September 2016

ABSTRACTThe metabolic increment that occurs after feeding demands cardiovascular adjustments to be maintained, as increased heart rate (fH) and cardiac output. In mammals, postprandial tachycardia seems to be triggered by an increase in adrenergic activity and by nonadrenergic noncholinergic (NANC) factors, while in ectothermic vertebrates, this adjustment seems to be linked to a withdrawal of vagal drive as well as to NANC factors. Because the factors behind postprandial tachycardia have not yet been investigated in crocodilians, the present study sought to evaluate the postprandial tachycardia mediators in the broad‐nosed caiman. To this end, fasting and digesting animals were instrumented with intraperitoneal cannula and subcutaneous electrocardiogram electrodes (for the measurement of fH, cardiac autonomic tones, and total fH variability, as well as for a power spectral analysis of fH). Data were then collected with the animals in an untreated state, as well as after muscarinic cholinergic blockade with atropine (2.5 mg kg–1) and after double autonomic blockade with atropine and propranolol (5.0 mg kg−1). Fasting animals’ fH was ∼18 bpm, a value which increased to ∼30 bpm during digestion. After the double autonomic blockade, fasting animals exhibited an fH of ∼15 bpm, while digesting animals’ fH was ∼23 bpm. This result is evidence of the presence of NANC factors with positive chronotropic effects acting during digestion. The calculated autonomic tones showed that, after feeding, the adrenergic tone increased while the cholinergic tone remained unchanged. Finally, fH variability analyses revealed that this adrenergic increase is primarily derived from circulating catecholamines.
Dynamic contrast‐enhanced MRI of the prostate: An intraindividual assessment of the effect of temporal resolution on qualitative detection and quantitative analysis of histopathologically proven prostate cancer
Authors: Ream Justin M. , Doshi Ankur M. , Dunst Diane , Parikh Nainesh , Kong Max X. , Babb James S. , Taneja Samir S. , Rosenkrantz Andrew B. 
Published: September 2016

PurposeTo assess the effects of temporal resolution (RT) in dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) on qualitative tumor detection and quantitative pharmacokinetic parameters in prostate cancer.Materials and MethodsThis retrospective Institutional Review Board (IRB)‐approved study included 58 men (64 ± 7 years). They underwent 3T prostate MRI showing dominant peripheral zone (PZ) tumors (24 with Gleason ≥ 4 + 3), prior to prostatectomy. Continuously acquired DCE utilizing GRASP (Golden‐angle RAdial Sparse Parallel) was retrospectively reconstructed at RT of 1.4 sec, 3.7 sec, 6.0 sec, 9.7 sec, and 14.9 sec. A reader placed volumes‐of‐interest on dominant tumors and benign PZ, generating quantitative pharmacokinetic parameters (ktrans, ve) at each RT. Two blinded readers assessed each RT for lesion presence, location, conspicuity, and reader confidence on a 5‐point scale. Data were assessed by mixed‐model analysis of variance (ANOVA), generalized estimating equation (GEE), and receiver operating characteristic (ROC) analysis.ResultsRT did not affect sensitivity (R1all: 69.0%–72.4%, all Padj = 1.000; R1GS≥4 + 3: 83.3–91.7%, all Padj = 1.000; R2all: 60.3–69.0%, all Padj = 1.000; R2GS≥4 + 3: 58.3%–79.2%, all Padj = 1.000). R1 reported greater conspicuity of GS ≥ 4 + 3 tumors at RT of 1.4 sec vs. 14.9 sec (4.29 ± 1.23 vs. 3.46 ± 1.44; Padj = 0.029). No other tumor conspicuity pairwise comparison reached significance (R1all: 2.98–3.43, all Padj ≥ 0.205; R2all: 2.57–3.19, all Padj ≥ 0.059; R1GS≥4 + 3: 3.46–4.29, all other Padj ≥ 0.156; R2GS≥4 + 3: 2.92–3.71, all Padj ≥ 0.439). There was no effect of RT on reader confidence (R1all: 3.17–3.34, all Padj = 1.000; R2all: 2.83–3.19, all Padj ≥ 0.801; R1GS≥4 + 3: 3.79–4.21, all Padj = 1.000; R2GS≥4 + 3: 3.13–3.79, all Padj = 1.000). ktrans and ve of tumor and benign tissue did not differ across RT (all adjusted P values [Padj] = 1.000). RT did not significantly affect area under the curve (AUC) of Ktrans or ve for differentiating tumor from benign (all Padj = 1.000).ConclusionCurrent PI‐RADS recommendations for RT of 10 seconds may be sufficient, with further reduction to the stated PI‐RADS preference of RT ≤ 7 seconds offering no benefit in tumor detection or quantitative analysis.Level of Evidence: 3J. MAGN. RESON. IMAGING 2017;45:1464–1475
Comparing Different Synthetic Talc as Fillers for Polyurethane Nanocomposites
Authors: Dias Guilherme , Prado Manoela , Carone Carlos , Ligabue Rosane , Dumas Angela , Le Roux Christophe , Micoud Pierre , Martin François , Einloft Sandra 
Published: September 2016

SummaryThis work presents the syntheses of PU nanocomposites, by in situ polymerization technique, using different synthetic talcs as inorganic filler. The fillers were obtained from two different hydrothermal treatments and composition (talc‐Mg and talc‐Ni). For nanocomposites syntheses 3% w/w of synthetic talc were added related to the weight of pure polymer. Samples were characterized by Fourier Transform Infrared Spectroscopy (FTIR), X‐Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) to understand the influence of the fillers syntheses and composition in morphological and thermal properties of the obtained nanocomposites. When talc‐Ni was used as filler, the resulting nanocomposite was intercalated while with talc‐Mg was exfoliated into the polyurethane matrix. Both fillers have increased the thermal properties of the polymer, but the exfoliated nanocomposite provided higher thermal stability.
Recycling of Post‐Consumer HDPE Drug Packaging with Banana Pseudostem Fiber
Authors: Collet Adriana , Flach Michel V. , da Silva Patrícia A. , Catto André Luís , Klauck Cláudia Regina , Rodrigues Marco Antônio Siqueira , Jahno Vanusca D. 
Published: September 2016

SummaryAs the life expectancy of the population increases, the quantity of solid waste produced has also risen. There is therefore a clear need to recycle materials, particularly polymers, and it is very important to reduce the time taken for materials to degrade after they have been discarded. The objective of this study was to develop a composite material from a mixture of waste drug packaging made from HDPE and fiber from the pseudostems of banana plants. A series of experiments were conducted to determine the characteristics of this compound, including tests of its mechanical properties, analyses with scanning electron microscopy and infrared spectroscopy, and tests of biodegradability and ecotoxicity. The infrared analysis showed that the compound was free from chemical groups that could indicate contamination by medications. The biodegradability assessment showed that the HDPERC5 compound took 28% less time to degrade after use was than the post‐consumer HDPE (HDPER). The HDPERC5 compound exhibited the best results for possible use for production of domestic utilities, in addition to a shorter degradation time if its final disposal destination were to be a landfill.
Accuracy of weight loss information in Spanish search engine results on the internet
Authors: Cardel Michelle I. , Chavez Sarah , Bian Jiang , Peñaranda Eribeth , Miller Darci R. , Huo Tianyao , Modave François 
Published: September 2016

ObjectiveTo systematically assess the quality of online information related to weight loss that Spanish speakers in the U.S. are likely to access.MethodsThis study evaluated the accessibility and quality of information for websites that were identified from weight loss queries in Spanish and compared this with previously published results in English. The content was scored with respect to five dimensions: nutrition, physical activity, behavior, pharmacotherapy, and surgical recommendations.ResultsSixty‐six websites met eligibility criteria (21 commercial, 24 news/media, 10 blogs, 0 medical/government/university, 11 unclassified sites). Of 16 possible points, mean content quality score was 3.4 (SD = 2.0). Approximately 1.5% of sites scored greater than 8 (out of 12) on nutrition, physical activity, and behavior. Unsubstantiated claims were made on 94% of the websites. Content quality scores varied significantly by type of website (P < 0.0001) with unclassified websites scoring the highest (mean = 6.3, SD = 1.4) and blogs scoring the lowest (mean = 2.2, SD = 1.2). All content quality scores were lower for Spanish websites relative to English websites.ConclusionsWeight loss information accessed in Spanish Web searches is suboptimal and relatively worse than weight loss information accessed in English, suggesting that U.S. Spanish speakers accessing weight loss information online may be provided with incomplete and inaccurate information.
Tolerance and effectiveness of nivolumab after pediatric T‐cell replete, haploidentical, bone marrow transplantation: A case report
Authors: Shad Aziza T. , Huo Jeffrey S. , Darcy Courtney , Abu‐Ghosh Amal , Esposito Giuseppe , Holuba Mary‐Jo , Robey Nancy , Cooke Kenneth R. , Symons Heather J. , Chen Allen R. , Llosa Nicolas J. 
Published: September 2016

AbstractTo date, there has been a lack of pediatric experience regarding the efficacy and tolerability of immune checkpoint inhibitors after haploidentical hematopoietic stem cell transplant (HSCT). We present the case of a 22‐year‐old female with multiple‐relapsed Hodgkin lymphoma (HL) who presented with a new relapse after haploidentical (post‐haplo) HSCT. Anti‐PD‐1 therapy with nivolumab resulted in significant objective disease response and clinical improvement without notable side effects, including the absence of a graft‐versus‐host disease (GVHD). This case report suggests that immune checkpoint inhibition may be safely tolerated even in the setting of haploidentical HSCT, without triggering overt GVHD.
Eliciting the child's voice in adverse event reporting in oncology trials: Cognitive interview findings from the Pediatric Patient‐Reported Outcomes version of the Common Terminology Criteria for Adverse Events initiative
Authors: Reeve Bryce B. , McFatrich Molly , Pinheiro Laura C. , Weaver Meaghann S. , Sung Lillian , Withycombe Janice S. , Baker Justin N. , Mack Jennifer W. , Waldron Mia K. , Gibson Deborah , Tomlinson Deborah , Freyer David R. , Mowbray Catriona , Jacobs Shana , Palma Diana , Martens Christa E. , Gold Stuart H. , Jackson Kathryn D. , Hinds Pamela S. 
Published: September 2016

AbstractBackgroundAdverse event (AE) reporting in oncology trials is required, but current practice does not directly integrate the child's voice. The Pediatric Patient‐Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO‐CTCAE) is being developed to assess symptomatic AEs via child/adolescent self‐report or proxy‐report. This qualitative study evaluates the child's/adolescent's understanding and ability to provide valid responses to the PRO‐CTCAE to inform questionnaire refinements and confirm content validity.ProcedureFrom seven pediatric research hospitals, children/adolescents ages 7–15 years who were diagnosed with cancer and receiving treatment were eligible, along with their parent‐proxies. The Pediatric PRO‐CTCAE includes 130 questions that assess 62 symptomatic AEs capturing symptom frequency, severity, interference, or presence. Cognitive interviews with retrospective probing were completed with children in the age groups of 7–8, 9–12, and 13–15 years. The children/adolescents and proxies were interviewed independently.ResultsTwo rounds of interviews involved 81 children and adolescents and 74 parent‐proxies. Fifteen of the 62 AE terms were revised after Round 1, including refinements to the questions assessing symptom severity. Most participants rated the PRO‐CTCAE AE items as “very easy” or “somewhat easy” and were able to read, understand, and provide valid responses to questions. A few AE items assessing rare events were challenging to understand.ConclusionsThe Pediatric and Proxy PRO‐CTCAE performed well among children and adolescents and their proxies, supporting its content validity. Data from PRO‐CTCAE may improve symptomatic AE reporting in clinical trials and enhance the quality of care that children receive.