bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract C118: Modulation of Prostate Cancer Microenvironment and Immune Responses by SPDEF
Authors: Vatanmakanian Mousa K. , Sanchez-Pino Maria , Zhang Guanyi K. , Koul Sweaty , Puttalingaiah Ramesh T. , Dean Mathew , Wyczechowska Dorota K. , Ochoa Augusto , Koul Hari K 
Published: September 2024

Abstract
Introduction: The prostate cancer (PCa) microenvironment plays a pivotal role in modulating immune responses, potentially impacting disease progression and treatment outcomes. SPDEF, a transcription factor, has been implicated in PCa progression, yet its influence on the tumor immune microenvironment remains incompletely understood. Methods: To comprehensively evaluate the impact of SPDEF-mediated changes in the PCa microenvironment on immune cells, we employed multiple experimental approaches. Firstly, utilizing the ProcartaPlex Human Cytokine & Chemokine Panel 1 16plex assay, we analyzed cytokine and chemokine alterations in cell culture supernatants from various PCa cell line models—PC3-VC, PC3-SPDEF, RC77/T-VC, RC77/T-SPDEF, LNCaP-VC, and LNCaP-shSPDEF. Subsequently, human primary T cells were exposed to PCa cell-derived conditioned media to assess their proliferation and activation status, using IncuCyte cell imaging and flow cytometry, respectively. Results: Our ProcartaPlex assay validated transcriptomic observations from RNA-seq experiment, confirming elevated cytokine/chemokine levels in SPDEF-overexpressing models and decreased levels in SPDEF-suppressed conditions. Notably, T cell proliferation assays demonstrated increased proliferation in response to SPDEF-overexpressing PCa conditional media and diminished proliferation in SPDEF-suppressed conditions. Moreover, SPDEF downregulation led to decreased proliferation in both CD4+ and CD8+ T cells. Assessing CD8+ T cell activation markers revealed varying impacts on IFN-γ expression, showing reduced levels in LNCaP-shSPDEF but inconclusive effects in PC3-SPDEF overexpression models. Conclusions: These findings highlight the complex interplay between SPDEF alterations in the PCa microenvironment and immune cell behavior, particularly T cell proliferation and activation. The observed effects underscore the complexity of SPDEF-mediated alterations on immune responses within the tumor milieu. Further investigations into the divergent effects of SPDEF on T cell dynamics are warranted to elucidate the precise mechanisms governing these interactions, potentially offering insights into novel therapeutic targets for PCa.
Citation Format: Mousa K. Vatanmakanian, Maria Sanchez-Pino, Guanyi K. Zhang, Sweaty Koul, Ramesh T. Puttalingaiah, Mathew Dean, Dorota K. Wyczechowska, Augusto Ochoa, Hari K Koul. Modulation of Prostate Cancer Microenvironment and Immune Responses by SPDEF [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C118.
Abstract C121: Racial differences in expression of the oxygen-sensor BACH1 in breast cancer
Authors: Nguyen Long C. , Dann Christopher , Yang Dongbo , Henn Madeline , Shi Emily , Li Thomas , Schechter Kent , Stock Letícia , Liu Wenchao , Matossian Margarite , Valdespino Andrea , Han Yoo Jane , Zhang Jing , Yerradoddi Geetha Priyanka , Li Yan , Matsumoto Mitsuyo , Olopade Olufunmilayo I , Igarashi Kazuhiko , Rosner Marsha R 
Published: September 2024

Abstract
Hypoxia is an important hallmark of aggressive solid tumors and a key driver of metastasis and resistance to therapy. Hypoxic stress induces the activation of various factors, such as hypoxia- inducible factors (HIFs), which facilitate cellular adaptation and promote tumorigenesis. Given the complexity of this mechanism, identifying novel targets that sensitize hypoxic tumors to therapy could have significant clinical impact. We demonstrate HIF-independent induction of BACH1 within multiple TNBC (Triple-Negative Breast Cancer) cell lines and patient-derived organoids under hypoxic conditions. Utilizing ChIP-seq, bulk, single-cell and spatial transcriptomics across diverse BACH1 knockout tumor models, our study revealed that BACH1 selectively and directly modulates the transcriptional response associated with hypoxia and stress in TNBC. TGCA analysis reveals racial disparities in BACH1 mRNA expression in TNBC BACH1 mRNA and activity across all breast cancer subtypes (Basal, Her, LumA, LumB). Our findings suggest that BACH1 is an oxygen-sensitive mediator of hypoxia and a promising therapeutic target for mitigating hypoxia-induced pro-metastatic signaling and treatment resistance. These results also highlight the necessity of accounting for racial differences in BACH1 expression and function as a means of developing targeted therapy that takes into account racial disparities in TNBC.
Citation Format: Long C. Nguyen, Christopher Dann, Dongbo Yang, Madeline Henn, Emily Shi, Thomas Li, Kent Schechter, Letícia Stock, Wenchao Liu, Margarite Matossian, Andrea Valdespino, Yoo Jane Han, Jing Zhang, Geetha Priyanka Yerradoddi, Yan Li, Mitsuyo Matsumoto, Olufunmilayo I Olopade, Kazuhiko Igarashi, Marsha R Rosner. Racial differences in expression of the oxygen-sensor BACH1 in breast cancer [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C121.
Abstract C137: Exploring cardiotoxicity risk factors among patients diagnosed with breast cancer
Authors: Schiaffino Melody K , Nguyen Van "Vannie" K. , Rash Dominique , Fernandez Alicia 
Published: September 2024

Abstract
Introduction Heart disease is the second most common cause of death for cancer survivors after their cancer diagnosis. Patients diagnosed with cancer, especially those with left-side breast cancer are at higher risk for treatment related toxicity. This burden is exacerbated for vulnerable patients that experience structural and chronic risk factors such as language barriers and disability which contribute to poorer survival. This study compared multi-level factors and their effect on age of diagnosis. Methods We explored a diverse population of N=1795 patient electronic medical records for patients diagnosed with left-side breast cancer and compared characteristics of patients by age, race, ethnicity, history of heart disease, disability status. Descriptive and Kruskal-Wallis ANOVA models were used to compare groups. Results The mostly female cohort of language diverse patients had an average of 66 years, most were White (64.5%), retired (52.1%), and on Medicare (43.2%). Approximately 17.8% were Latine and 13.3% needed an interpreter. Disability status was 9.7% and 8.8% had a history of heart disease. Patients diagnosed with breast cancer who were disabled were younger compared to those without a disability (60 yrs vs 67, p&lt;.0001). When we compared language proficiency, we found this difference persisted as patients with a disability and were limited English were younger compared to patients that experienced neither (61yrs vs 67, p&lt;.0001). Discussion This exploratory analysis is one of the first to explore the role of disability among minoritized and limited English proficient patients with breast cancer. More research is necessary to understand how to best plan and support diverse and disabled patients diagnosed with cancer to minimize their risk and improve outcomes.
Citation Format: Melody K Schiaffino, Van "Vannie" K. Nguyen, Dominique Rash, Alicia Fernandez. Exploring cardiotoxicity risk factors among patients diagnosed with breast cancer [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C137.
Abstract C155: Differential colorectal cancer mortality across racial and ethnic groups: Impact of socioeconomic status, clinicopathology, and treatment-related factors
Authors: Fwelo Pierre , Adekunle Toluwani E. , Adekunle Tiwaladeoluwa B. , Garza Ella R. , Huang Emily S. , Lawrence Wayne R. , Ewing Aldenise P. 
Published: September 2024

Abstract
Introduction: Non-Hispanic Black colorectal cancer (CRC) patients have a higher risk of mortality compared to most other racial/ethnic groups. Limited studies examine the contribution of socioeconomic (SES), clinicopathologic, or treatment variations toward mortality disparities. This retrospective cohort investigation examined the extent to which SES, clinicopathologic, and treatment factors explain racial/ethnic differences in CRC mortality. Methods: We studied 146,515 individuals ,18+ years old, with a confirmed diagnosis of CRC within 2010-2017 identified from the Surveillance, Epidemiology, and End Results (SEER) database. We performed Cox regression analyses to examine the association of race/ethnicity, surgery type, and tumor site with all-cause mortality and CRC-specific mortality. We then performed mediation analysis to quantify the extent to which mortality differences were mediated by SES, clinicopathologic, and treatment factors. Results: Non-Hispanic Black patients had a significantly higher hazard of all-cause mortality than non-Hispanic White patients. The non- Hispanic White versus non-Hispanic Black patients’ comparison demonstrated that variations in SES and clinicopathologic factors significantly explained 46.63% (indirect effect HR: 0.92, 95% CI 0.91-0.93) and 10.87% (indirect effect HR: 0.98, 95% CI 0.97-99) of the excess all-cause mortality among non-Hispanic Black patients, respectively. The Hispanic vs. non-Hispanic Black comparisons identified SES as the most influential mediator, explaining 19.68% of the excess all-cause mortality. The proportions mediating for CRC-specific mortality showed comparable outcomes to all-cause mortality. Conclusions Non-Hispanic Black patients had greater risk for all-cause mortality and CRC-specific mortality attributed to SES and clinicopathologic variations compared to other racial/ethnic groups. Future studies should investigate equity in healthcare through interventions addressing SES-related disparities.
Citation Format: Pierre Fwelo, Toluwani E. Adekunle, Tiwaladeoluwa B. Adekunle, Ella R. Garza, Emily S. Huang, Wayne R. Lawrence, Aldenise P. Ewing. Differential colorectal cancer mortality across racial and ethnic groups: Impact of socioeconomic status, clinicopathology, and treatment-related factors [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C155.
Abstract C158: Contribution of multi-organ cancer predisposition genes for gastric cancer risk of different histological subtypes
Authors: Estrada-Florez Ana P. , Lott Paul C. , Carvajal Carmona Luis G. 
Published: September 2024

Abstract
Approximately 10% of gastric cancer (GC) cases exhibit familial clustering, yet only 1-3% can be explained by known hereditary syndromes, being Hereditary Diffuse Gastric Cancer (HDGC) the most well-established disease predisposing for diffuse gastric cancer. Familial intestinal gastric cancer (FIGC) has been defined clinically, but it remains mostly genetically unexplained. Likewise, the heritability of mixed GC remains to be uncovered. We aimed to estimate the frequency of known cancer predisposition gene variants in GC cases with family history of cancer and/or early onset. We evaluated the contribution of pathogenic and likely pathogenic (P/LP) variants in well-established and multi-organ cancer predisposition genes for GC risk in a large multi-center study involving 750 GC patients, either by targeted sequencing or whole exome sequencing. We identified 45 patients (6%) with P/LP variants in ATM (17 cases), BRCA2 (10 cases), MLH1 (five cases), TP53 (three cases), BRCA1, PALB2, RAD51D and CHEK2 (two patients each), and RAD51C and PMS2 (one case each), all mutually exclusive. The P/LP variant prevalence was higher in intestinal (9.8%) than in diffuse (4.3%) or mixed GC (4.5%) (p-value=0.023), with no clear difference per mutated gene by histological subtypes. Only sixteen of the 45 variant carriers fulfilled the criteria for genetic testing of at least one cancer predisposition syndrome. Our findings indicate that multi- organ cancer predisposition genes should be included in gene panels used for investigating germline variants in GC patients, especially when there is family history of cancer but irrespective of histology subtype, as this would increase the chance of identifying patients that might benefit from prevention and targeted treatment strategies.
Citation Format: Ana P. Estrada-Florez, Paul C. Lott, Luis G. Carvajal Carmona. Contribution of multi-organ cancer predisposition genes for gastric cancer risk of different histological subtypes [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C158.
Abstract PR016: Do U.S. quitsites present information related to providing services for LGBTQ individuals? An audit study
Authors: Ramos Santiago Jeffrey Wilmer , McIntosh Scott , Orfin Rafael , Lara Daimarelys , Joseph Skylar , Kaur Manpreet , Ramos-Pibernus Alixida , Cupertino Ana Paula , Ossip Deborah , Cartujano-Barrera Francisco 
Published: September 2024

Abstract
Introduction: Most U.S. quitlines have quitsites, websites designated to promote their services. However, little is known about the design of the quitsites and if they present information relevant to providing services for LGBTQ individuals. The present study audited quitsites for the presence of information regarding services for LGBTQ individuals. Methods Using an audit checklist consisting of nine criteria, a cross-sectional audit of the U.S. quitsites was conducted between October 16th, 2023, and November 8th, 2023. The audit was divided into two phases: 1) auditors evaluated each quitsite separately, and 2) auditors met to discuss points of disagreement and reach a consensus. The interrater agreement was calculated. Frequencies and percentages were calculated for each criterion. Results The audit evaluated a total of 46 quitsites. Auditors had an interrater agreement of 96.85%. Findings indicated that most quitsites had at least a singular mention of the LGBTQ community somewhere on their website (84.8%). However, only 4.3% of the quitsites mentioned the LGBTQ community on their landing page. Conclusions It is recommended that quitsites explicitly mention services for LGBTQ individuals on their landing page, which has the potential to engage the community into quitline services and reduce tobacco-related disparities. Implications This study represents the first audit to assess whether U.S. quitsites present information relevant to providing services for LGBTQ individuals. This research adds knowledge about how official quitline websites address services for the LGBTQ community. The results suggest that quitsites explicitly mention the provision of services for LGBTQ individuals on their landing page, which has the potential to engage LGBTQ individuals into quitline services and reduce tobacco-related disparities.
Citation Format: Jeffrey Wilmer Ramos Santiago, Scott McIntosh, Rafael Orfin, Daimarelys Lara, Skylar Joseph, Manpreet Kaur, Alixida Ramos-Pibernus, Ana Paula Cupertino, Deborah Ossip, Francisco Cartujano-Barrera. Do U.S. quitsites present information related to providing services for LGBTQ individuals? An audit study [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr PR016.
Animal Protection Officers: Professional Identity, Professional Stressors, and Mental Health Needs
Authors: Meyer Laura , Brown Courtney , Nikitina Katia , Ettinger Daniel 
Published: September 2024

Abstract
Animal protection officers (APOs) fulfill critical community roles but are underrepresented in academic literature. This study explored APOs’ professional identities, professional stressors, positive job aspects, and mental health needs and access. Our mixed-methods design featured a survey followed by interviews. The survey was disseminated to APOs from four local agencies. Results from 18 respondents revealed that seeing a child injured by an animal or an animal injured by a human were the most stressful work situations. Positive job aspects included helping animals, public education, and supporting community safety. Only four respondents had accessed mental health services for job-related issues. Nine respondent interviews yielded themes addressing how APOs make meaning, stressors and resilience factors, and mental health supports. Recommendations based on survey and interview responses are provided.
Under the skin: Portraits by Abraham de Vries (c. 1590-1649/50) recognised and revealed
Authors: van de Puttelaar Carla , Meijer Fred G. 
Published: September 2024

This article discusses four portraits by Abraham de Vries (c. 1590-1649/50), three of which were recently recognised as the artist’s work, and all of which were subject to changes over time. The appearance of these portraits, as the authors came across them, prompted further investigation.
The first two are portraits of the same girl (figs. 1a and 2a) from c. 1629 that originally had virtually the same appearance, as technical research has revealed. The first was reduced in size, the second was overpainted substantially, particularly in the costume.
A portrait of a bearded man (fig. 11a) had been sold as a portrait of a rabbi by Simon Kick, but technical examination revealed that it was initially painted as a portrait of the French garden designer Jacques Boyceau, signed in monogram by De Vries and dated 1629 under a layer of overpaint. The original appearance of the portrait is known through a contemporary print (fig. 14). Interestingly, later changes appear to have been executed by De Vries himself, but the circumstances remain unclear. Additionally, a signed portrait of an unidentified sitter, also from 1629 and now in the Petit Palais in Paris (fig. 12a), had received a different collar at some point in its history, which was cleaned off before its acquisition by the museum.
Similarities in handling and execution with other portraits by Abraham de Vries, for instance in the hair, collars and eyes, prove his authorship of the four portraits that are the focus of this article. They enrich the painter’s oeuvre and further confirm his excellent abilities as a portraitist in the first half of the seventeenth century.
Jesuits, Jansenists, and the Culture Wars
Authors: Stróżyński Mateusz 
Published: September 2024

Abstract
This introductory article explores the relevance of studying the Jesuit-Jansenist conflict in early modern France against the broader background of modernity as such and its inherent problems with fragmentation, isolation, and polarization in all areas of culture. It begins with a reference to the particular use of the study of early modernity and its religious and sociopolitical problems by the two prominent dissidents of the twentieth century, Leszek Kołakowski (1927–2009) and Jan Patočka (1907–77), in order to draw some potential parallels between the contemporary “culture wars” and the conflict between the Jesuits and the Jansenists. The contributions, stemming from a conference held at Adam Mickiewicz University in Poznań in March 2023, celebrating the four-hundredth anniversary of the birth of Blaise Pascal, shed light on various aspects of classical culture, education, tradition, and innovation in the areas of theatre, music, and philosophy in seventeenth-century France.
Seneca, Corneille, and the Ghost of Jesuit Classicism
Authors: Boparai Jaspreet Singh 
Published: September 2024

Abstract
The precise effects of Jesuit education can be difficult to discern in a given writer or artist. Little is known about Pierre Corneille’s (1605–84) humanist formation at the Jesuit college in Rouen; like his philosophical orientation, its nature must be extrapolated from scanty, equivocal evidence. This article traces Corneille’s reception of Seneca (c.4 bce–65 ce) in his early tragedy Médée and his heroic drama Cinna in an attempt to come to grips with his idiosyncratic classicism, which diverges considerably from contemporary Aristotelianism. Corneille is a practical man of the theatre and focuses less on Aristotle than on Seneca’s philosophical prose, as well as his tragedies. By the time he comes to compose Rodogune, Corneille has absorbed Seneca so completely that it seems almost impossible to articulate precisely how his work is “Senecan,” except to point to Seneca’s shadow. Perhaps Jesuit classicism is easier to study in a less idiosyncratic writer like Thomas Corneille (1625–1709)?
The French Leçons de Ténèbres and the Foundation of the Jansenist Music Criticism
Authors: Favier Thierry 
Published: September 2024

Abstract
The spread of the Leçons de ténèbres in the French capital and later in large provincial cities contributed to the evolution of musical practices and the listeners’ sensibilities and favored the incorporation of religious music into secular musical calendars. This explains why, from the end of the seventeenth century, the genre has been the focus of criticism from clerics and lay people of different persuasions, who denounced the contamination of the church by opera, using the conventional argument of antitheatricality. Initially focused on the Lessons, the criticism’s terms and arguments used against the Lessons became instrumental in the Jansenist’s critique of modern music throughout the eighteenth century, particularly to contest Jesuit musical patronage and Jesuits’ sensualist conception of music for religious services. While Jansenist criticism portrays an irreducible opposition between opponents and supporters of modern music, the latter being equated with the Jesuits, the article highlights the ambiguities of Jansenist positions. An analysis of these criticisms reveals a double reference to the Augustinian tradition, on the one hand concerning the opposition between musica luxuriantis and musica sapientis and, on the other, a moral reflection on musical pleasure’s legitimacy based on individual introspection. In the second half of the eighteenth century, the condemnation of all modern forms of religious music appeared to contradict the claim to a part of this Augustinian heritage.
Range shifts and non-monotonic clines in studies of Bergmann’s rule as applied to climate change
Authors: Shelomi Matan 
Published: September 2024

Abstract
Bergmann’s rule states that organisms should be smaller in warmer climates. This traditionally implied warmer latitudes, but also applies to warmer eras, as forming due to climate change. Integrating spatial and temporal ecology (chronoecogeography) can help us understand and predict how different species respond to environmental changes over time. However, study results can be misinterpreted if researchers do not take steps in the data collection or analysis stages to account for range shifting or non-monotonic patterns. Multiple variables can cause an organism’s geographic and recent temporal size clines to differ significantly, as seen in a review in this article, and these cannot easily be modeled. Range shifting can affect Bergmann’s rule modeling, especially regarding effects from climate change, and this article suggests methods to account for this when incorporating the dimension of time into climate change-focused ecogeographic research.