bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of Augmented Reality of Laboratory Building and Room Using Fast Corner Detection Algorithm
Authors: Ilhami Ahmad Mika , Ikhsan Muhammad 
Published: September 2024

The Laboratory Buildsing is one of the buildings in Campus IV UINSU which is used to carry out practicum activities, many of the lecturers students and the community do not know the location and also the rooms in the Laboratory building. This research aims to make this application can provide convenience for users such as students, lecturers and the public to obtain information about laboratory buildings. In this research, the method used is Marker Based Tracking where application users must scan the marker first in order to see 3D objects from a floor plan and laboratory building. The results of this study in the form of Augmented Reality applications using Android as an operating system, on the marker added with the Fast Corner Detection algorithm aims to speed up real-time computing time with the consequence of reducing the level of accuracy of corner detection. The conclusion of AR and Fast Corner Detection can be implemented through a scan of the marker, the result obtained is that when scanning the marker a point from the FCD algorithm will appear indicating that the point on this marker is the result of the implementation of the FCD algorithm.
La philosophie comme législation axiologique Platon nietzschéen?
Authors: Wotling Patrick 
Published: September 2024

In Nietzsche’s view, Plato certainly is not just any philosopher. First and foremost because of what Nietzsche refers to as his particular « sphinx nature » (BGE, § 28), his insuperable and artistic « secrecy » (BGE, § 28), his ability to hide, and sometimes even to lie : which means that it is extremely difficult to ascribe to him any precise, indisputable philosophical position, doctrine or notion. As is apparent, Nietzsche’s Plato is therefore completely different from the character usually discussed by other philosophers. Why then, is he so intensely interested in Plato if he does not take his so-called major theories seriously ? A closer scrutiny of Nietzsche’s corpus reveals that there is something really specific about Plato : his deep, mostly hidden, and sharp-sighted understanding of philosophy (and philosophers) ; namely not as a theoretical search for knowledge and truth, but as practical value creation and legislation, in other words as an activity intent on carving a new type of human life and being, very much akin to Nietzsche’s own analysis.
Transdermal carbon dioxide may accelerate hoof growth in healthy, sound horses in a short-term, randomized, controlled clinical trial
Authors: Rudnick Meredith J. , Stewart Holly L. , Burleson Modesty D. , Levine David G. 
Published: September 2024

Abstract

OBJECTIVE
Slow hoof growth poses a clinical challenge when hoof wear exceeds natural growth. Many treatment options have been reported without controlled prospective trials. The objective of this study was to evaluate the effect of transdermal CO2 on the rate of growth in treated hooves.

METHODS
A prospective, randomized, blinded, crossover study of 14 Warmblood mares. Horses were randomly assigned a number and allocated for treatment of the front feet with room air or CO2 for 30 minutes 3 times per week, and groups were switched after 5 weeks. Hoof growth was measured on the dorsal midline and the quarters of each front foot. The distance from coronary band to lines made on the hoof wall was measured at the beginning, middle, and end of the study. The percentage of change in length at each location relative to baseline was evaluated at 5 weeks and 10 weeks using nonparametric analyses.

RESULTS
All treatments were successfully administered. The left front medial (P = .028) and right front lateral (P = .03) sites of the CO2-treated hooves increased growth compared to the room air group at the 5-week point.

CONCLUSIONS
The results of this study suggest that repeated, noninvasive transdermal application of CO2 may accelerate hoof growth in normal horses over a 5-week treatment period.

CLINICAL RELEVANCE
This study suggests that transdermal CO2 may increase the rate of hoof growth in normal horses. The mechanism of action of this treatment is unclear, and further studies are required to fully elucidate the potential effects.
Benefits of Upper-Extremity Strength Workout on Muscle and Fat-Free Mass Through Home-Based Lung Rehabilitation in COPD Patients
Authors: Tarigan A. H. , Tarigan A. P. , Pandia P. , Eyanoer P. C. 
Published: September 2024

Abstract

Background
COPD patients not only experience respiratory problems but can have fatigue, physical limitations and reduced overall quality of life. Pulmonary rehabilitation is the main non-pharmacological solution after pharmacological treatment based on COPD grouping. The main aim of this study is to evaluate the benefits of weight lifting strength training twice a week for 4 weeks for COPD patients using home-based pulmonary rehabilitation. It can be done independently by the patient, is easy to do anywhere and at any time and is free of cost. This can be one of the home-based pulmonary rehabilitation options that can be implemented in the future.

Methods
This research was a quasiexperimental study with 10 stable COPD patients. The patients underwent home pulmonary rehabilitation of twice-a-week weight-lifting strength exercises for 4 weeks. They were taught how to do the exercise during the initial visit at the hospital which they continued to do independently at home with the help of an instruction video containing the exercise movements. Muscle and fat-free mass measuring was conducted before and after the intervention. Patients were evaluated using videos which they sent to the researchers.

Results
COPD patients who concluded the home-based lung rehabilitation showed increase in muscle mass after the intervention (30.12 ± 3.83 SD, p = 0.017). Fat-free mass did not show any increase (49.13 ± 6.93 SD, p = 0.154).

Conclusion
Home pulmonary rehabilitation benefits patients as much as the traditional rehabilitation done at health-care centers. This was proven by the significant increase in muscle mass after the intervention despite no change found in fat-free mass, which could be remedied in the future by giving extra diet to meet patients’ nutrition needs.
Dose-response curves for the effects of Lactobacillus plantarum on growth performance, feed utilization, and health status of Litopenaeus vannamei shrimp. Optimizing the economic efficiency of supplementation
Authors: El-Raghi Ali Ali , Abu El-Naser Ibrahim A. , Amer Asem A. , Abdel-Warith Abdel-Wahab A. , Younis Elsayed M. , Davies Simon J. , Fath El-Bab Ahmed F. 
Published: September 2024

Abstract
A 14-weeks feeding trial was conducted to employ polynomial regression analysis to establish the optimal dosage of Lactobacillus plantarum (Lac) for enhancing the growth performance, digestive enzyme activities, and blood biochemical, redox balance, and immunity response of Litopenaeus vannamei shrimp (initial body weight = 2.94 ± 0.03 g). A total of 240 healthy Litopenaeus vannamei shrimp were randomly distributed into four equal groups and were fed diets containing 0, 200, 400 and 800 mg Lac /kg diet respectively for 98 days. Increasing the levels of dietary Lac cubically improved growth performance and feed utilization (
p
<0.01), the optimal doses were established at 600 and 650 mg Lac/kg diet, respectively. Muscles thickness decreased significantly in all treated group compared to the control (
p
<0.05). The dietary treatment quadratic ally affected total protein (
p
<0.0001), tri-glycerides (
p
<0.0001), and cortisol (
p
=0.0097), the optimal responses were observed at 650, 700, and 600 mg Lac/kg diet, respectively. Meanwhile the activities of liver enzymes (ALT and AST), the levels of blood urea and digestive enzymes (amylase and proteases) were cubically enhanced by the treatment, the optimal dosages were at 600 and 650 mg Lac/kg diet for liver enzymes, and urea concentration, respectively and at 650 and 700 mg Lac/kg diet for the activities of amylase and protease, respectively. With regards to redox balance, increasing the levels of Lac caused a quadratic decrease in the levels of malondialdehyde (
p
=0.0398) and a cubic increase in the activities of superoxide dismutase (
p
=0.0265), and catalase (
p
=0.0163), the corresponding dose–response curves showed that the optimal dose was at 650 mg/kg diet. However, the levels of total antioxidant capacity were in a quadratic increase (
p
=0.0372), maximizing at a level of 600 mg Lac / kg diet. Concerning the immunity response, both of lysozyme and IgM significantly affected by the dietary treatment (
p
=0.0002 and 0.0001, respectively), maximizing at 600 and 650 mg Lac/kg diet, respectively. Dietary supplementation of Lac had significant and substantial impacts on the economic efficiency (
p
<0.0001). In conclusion, the dietary inclusion of 600-700 mg Lac /kg diet can be used as an effective and practical feeding strategy to enhanced growth performance, feed efficacy, redox balance and nonspecific immune responses in Litopenaeus vannamei shrimp.
Effect of Different Protein Sources on the Meat Quality of Złotnicka Spotted Pigs with Particular Emphasis of Slaughter Body Weight
Authors: Szyndler-Nędza Magdalena , Świątkiewicz Małgorzata , Żak Grzegorz , Tyra Mirosław , Mucha Aurelia , Małopolska Martyna , Piórkowska Katarzyna , Szulc Karolina , Skrzypczak Ewa 
Published: September 2024

Abstract
The aim of the study was to determine the impact of protein feeding from Fabaceae plants and the final slaughter weight on the quality of meat of native Złotnicka Spotted pigs. The experiment was carried out on 96 fattening pigs (48 barrows and 48 gilts) of the Złotnicka Spotted breed. Animals were divided into 4 feeding groups: group A – control cereal-soybean mixture, and 3 experimental mixtures containing different types of domestic protein sources (groups B – lupin, C – faba beans and D – peas). All diets were isoproteic and isoenergetic within the fattening phase, i.e. grower and finisher. In addition, pigs were fattened to 3 different slaughter weights: 120, 130 and 140 kg. The type of protein had no effect on fattening and slaughter traits. These traits (feed intake [kg], gaily gain during fattening [g/day], mean backfat thickness [mm]) were influenced by the body weight of the pigs at slaughter (P<0.01). A statistically significant interaction effect was found between feeding group and body weight on the fat, the fatty acid profile of meat (longissimus lumborum) and on oxidative stability (thiobarbituric acid reactive substances – TBARS) of meat. Increasing the slaughter weight to 140 kg affects increasing the fat content (P<0.05) of meat (longissimus lumborum) primarily in groups of pigs fed on cereal-soy mix (A) and faba beans (C). In addition, fat up to 140 kg and feeding with faba beans (C) and peas (D) has a beneficial effect by reducing the proportion of PUFA n-6/n-3 in meat (P<0.05). Finally, the benefit of feeding pigs with faba beans (C) up to a slaughter weight of 140 kg is the reduction of TBARS of meat (P<0,05). In conclusion, increasing the slaughter weight up to 140 kg and the use in the feed mixture of faba beans improves the nutritional value and oxidation durability of pork.
Impact of Bacillus subtilis probiotic on growth, visceral and lymphatic organ weights, intestinal histo-morphology, and pathogenic bacteria of broilers
Authors: Khan Sajjad , Chand Naila , Hafeez Abdul , Ali Majid , Qattan Shaza Y. A. , Alam Mohammad , Siddiqui Shahrood A. , Nass Nada M. , AlMalki Fatemah , Abd El-Hack Mohamed E. , Al-Gheffari Hawazen K. , Al-Shehri Mohammed , Moustafa Mahmoud , Kamal Mahmoud 
Published: September 2024

Abstract
This work aimed to examine the impacts of dietary Bacillus subtilis (BS) supplementation on several parameters. Twelve groups of six hundred-day-old male Ross chicks were created for the study. Each treatment was allotted into five replicates, with ten birds each. Four distinct diet treatments were provided for 42 days: diet A served as the control, whereas diets B, C, and D had 125, 250, and 500 mg of BS per kg of feed. Every diet was fed in three stages: continuous (days 1-42) and starter only (days 1–21), finisher only (days 22–42), and both. The results showed that the D-3 and C-3 groups had significantly higher feed intake (FI), body weight gain (BWG), feed conversion ratio (FCR), livability, and European Production Efficiency Factor (EPEF).juo09 The D-3 and C-3 groups also showed the largest relative weights of the liver, gizzard, pancreas, bursa, and spleen, as well as the enhanced weights of these organs. Groups D-3 and C-3 had high villus height, decreased crypt depth, and enhanced VH: CD in the ileum, jejunum, and duodenum. The high levels of BS (D-3 and C-3) eliminated Salmonella, C. perfringens, and E. coli from the ileum, caecum, and colon. From the results above, a conclusion could be drawn that dietary BS supplementation could be a safe substitute for AGPs in broiler diets.
Utilizing pigs as a model for studying intestinal barrier function
Authors: Pieszka Marek , Szczepanik Kinga , Łoniewski Igor 
Published: September 2024

Abstract
Intestinal permeability has been extensively studied, particularly in gastrointestinal diseases such as inflammatory bowel disease, food allergy, visceral disease, celiac disease, and Crohn’s disease. These studies have established that changes in intestinal permeability contribute to the pathogenesis of many gastrointestinal and systemic diseases. While numerous works in the 20th century focused on this topic, it remains relevant for several reasons. Despite the development of new research techniques, it is still unclear whether changes in intestinal permeability are the primary mechanism initiating the disease process or if they occur secondary to an ongoing chronic inflammatory process. Investigating the possibility of stabilizing the intestinal barrier, thereby reducing its permeability preemptively to prevent damage and after the damage has occurred, may offer new therapeutic approaches. Increased intestinal permeability is believed to lead to reduced nutrient absorption, resulting in decreased immunity and production of digestive enzymes.
The feasibility of using white lupin meal in the feed of juvenile Siberian sturgeon (Acipenser baerii)
Authors: Szczepański Adrian , Adamek-Urbańska Dobrochna , Kasprzak Robert , Wiechetek Wiktoria , Szudrowicz Hubert , Ostaszewska Teresa , Piotrowska Iwona , Gomułka Piotr , Kozłowski Michał , Woźniak Małgorzata , Bober Helena , Śliwiński Jerzy , Kwiatkowski Maciej , Kawalski Kacper , Martynow Jakub , Bujarski Patryk , Wild Rafał , Sobień Magdalena , Pruchniak Pola , Kamaszewski Maciej 
Published: September 2024

Abstract
As with other fishes farming, sturgeon farming depends on the use of well-balanced feed to maintain production. Commercial feeds available on the market are often based on soy protein, which, unfortunately, has many adverse effects on these fish. Therefore, alternative constituents are being sought that could be used in sturgeon fish farming. This study was designed to assess the feasibility of using diets containing white lupin meal at levels of 5% and 10% for juvenile Siberian sturgeon, compared to a formulated control group without lupin inclusion and a reference group fed commercial feed. Histological and immunohistochemical analyses were performed, combined with digestive enzyme activity assays. This study showed that feeding with white lupin meal did not adversely affect the rearing parameters, histology, or enzyme metabolism of sturgeons. An increase in the length of intestinal folds in the anterior intestine was observed in the group with 10% lupin meal inclusion, while this trend was not present in the spiral intestine, which may be indicative of a compensatory physiological mechanism when fish are fed less digestible feed. Antioxidative mechanism impairment was also noted in the two experimental groups. However, further research is still required to determine the possibility of using white lupin meal in the feeding of sturgeon fish, especially for more mature specimens.
The Importance of Molecular Biological Analysis for the Laboratory Diagnostic of Homozygous Haemoglobin Malay
Authors: Bahar R , Zulkafli Z , Zulkeflee RH , Hassan MN , Rahman Wan S Wan Ab , Noor NH M , Ramli M , Hussin A , Abdullah AD , Iberahim S , Abdullah M , Yusoff S M 
Published: September 2024

Abstract
Haemoglobin (Hb) Malay is variant haemoglobin with a β++ thalassemia phenotype. The prevalence of Hb Malay in the Malaysian population was 5.5%. We describe a 58-year-old male who presented with symptomatic anaemia to the Hospital Universiti Sains Malaysia. Further history revealed that the patient had anaemia since the age of 28, and on regular follow-up at other hospital. Physical examination revealed pallor, jaundice and hepatosplenomegaly. The full blood count and peripheral blood smear showed hypochromic microcytic anaemia with anisopoikilocytosis, and many target cells. High-performance liquid chromatography results showed a β thalassemia trait. However, the diagnosis does not alight with the patient’s condition. Bone marrow aspirate was completed and showed reactive changes and erythroid hyperplasia. A molecular test was then performed for β globin gene mutation detection using Multiplex Amplification Refractory Mutation System (M-ARMS) PCR method. This revealed the result as homozygous codon 19 mutation or Hb Malay. Therefore, in this case report we would like to highlight the laboratory approaches, the challenges faced by the usual haematological investigations and the importance role of molecular testing in the diagnosis of severe anaemia.
The Spectrum and Frequency of Cystic Fibrosis Mutations in Albanian Patients
Authors: Kasmi I , Kasmi G , Basholli B , Sefa HS , Vevecka E 
Published: September 2024

Abstract

BACKGROUND
Cystic fibrosis (CF) is a genetic disease characterized by a wide spectrum of severity, resulting from the inheritance of a mutant allele of the gene for cystic fibrosis transmembrane conductance regulator (CFTR). The aim of the study was to present a CFTR mutation analysis among the Albanian population and to identify rare variants.

METHODS
We identified CFTR mutations in a representative cohort of CF patients comprising of Albanian patients and some Kosovo patients followed up by the Department of Pediatrics at the University Hospital Center “Mother Theresa” (UHCMT). Compiled clinical and genotypic data include 133 previously analyzed patients, of whom 116 have two identified mutations, 6 have only one known mutation, and 11 are unexamined.

RESULTS
The most frequent mutation is F508del (83.19%), followed by 621+1G>T (2.45%). Other mutations identified in decrease order are E822X, G85E, G542X, R1066C, R1070Q, R1158X, G1349D, N1303K, S466X, 1811+1G->C, E831X, CFTRdele2,3(21kb).

CONCLUSIONS
The data suggest that most of these patients can benefit from new modulatory therapies targeting CFTR mutations, translating to very hopeful prospects for these patients.
The Albanian population would benefit from Cystic Fibrosis neonatal screening, since outcomes can be improved through early diagnosis.
The Impact of the COVID-19 Pandemic on Individuals with Down Syndrome: A Croatian Survey
Authors: Barišić A , Ergović Ravančić M , Majstorović D , Vraneković J 
Published: September 2024

Abstract

Background
Severe acute respiratory syndrome coronavirus-2 infection has spread uncontrollably worldwide. Among the most vulnerable groups in society are populations with multiple comorbidities, including individuals with Down syndrome (DS).

Aim
Our aim was to conduct an online survey to assess the impact of COVID-19 on DS individuals in Croatia. We also explored the views of their parents and caregivers about the challenges they faced during COVID-19.

Methods
The anonymous online survey was launched in March 2022 and remained open until October 2022. Participants were conducted online through closed group on Facebook. The survey included questions about participant characteristics, medical information, clinical presentation of COVID-19, and challenges faced by the parents during COVID-19.

Results
A total of 268 surveys were collected and analysed. We found that age and body mass index of DS individuals were significantly and positively correlated with the clinical presentation of COVID-19. Lack of social activities, cancelled therapies, and psychological problems were the most frequently cited challenges during the pandemic.

Conclusion
Clinicians and caregivers should primarily be alert to the same COVID-19 signs and symptoms that occur in the general population (fever, cough, shortness of breath). Ongoing therapies, social activities, and psychological support should be cited as indispensable for maintaining physical health and emotional well-being in DS individuals.
Dual amylase/glucosidase inhibition, antilipolytic and antiproliferative potential of the aerial parts of Pistacia atlantica, Pistacia lentiscus and Pistacia terebinthus on a obesity related-colorectal cancer cell line panel
Authors: Hamlat Nadjia , Alqaraleh Moath , Kasabri Violet , Mizher Hussam , Hassani Aicha , Afifi Fatma , Alawi Sundos Al , Ouafi Saida , Khwaldeh Alia 
Published: September 2024

Abstract

Pistacia species (P. spp) have been used as a treatment for various diseases, including diabetes and inflammation. This study aimed to identify the main components of flavonoids in Pistacia species and evaluate the effect of aqueous extracts of P. spp on pancreatic enzymes and on cancer cells associated with obesity in colon and rectum. HPLC was used to identify the major components of flavonoids. The potent inhibitory effect of Pistacia species against pancreatic α-amylase, α-glucosidase and lipase was examined. The antiproliferative efficacy of the plant extract against several colorectal cancer cell lines were then measured. The main flavonoids component found in Pistacia species are quercetin-3-β-D-glucoside, rutin, kaempferol and vitexin. The starch blockade IC50 (µg/mL) of Pistacia species in a descending order were: P. lentiscus leaves: 1.09±0.01; P. atlantica leaves: 0.96±0.09 and P. atlantica fruits: 0.48±0.02. Pistacia species exerted promising inhibition effect for pancreatic lipase (PL). Besides the aglycones of P. atlantica leaves, all the tested aqueous extracts exerted appreciably novel antiproliferative activity against the tested colorectal cancer cell lines. This study provides useful indication for the Pistacia species as a potential novel therapeutic agent against diabesity and cancer.
Sternalis muscle, a rare anatomical variation with clinical implications
Authors: Tomaszewski Marek , Sienko Cezary , Skorka Katarzyna , Cendrowska-Pinkosz Monika 
Published: September 2024

Abstract
The sternalis muscle is a rare variant of the anterior chest wall musculature. Although its frequency in general population worldwide has been reported from 2% to 8%, its prevalence depends on regions and populations. The aim of this paper is to describe one of the first cases of sternalis muscle found in Central Europe. An anterior chest wall of 64-year-old white male was dissected during a regular anatomy class at Department of Human Anatomy. A right unilateral sternalis muscle was revealed and described. The unilateral sternalis muscle laid between the pectoral and the superficial thoracic fascia. The muscle was long and wide. In addition, it had a massive tendon. According to the Snosek et al. Classification, it was a “simple unilateral” type. This report presents another case of the sternalis muscle among humans. Although the sternalis muscle serves a minor role in body movement, its occurrence gives several clinical implications. The awareness of variability in the thoracic region is important during diagnostic and treatment processes or in surgical operation planning.