bluuebunny/crossref_metadata_2025_split huggingface dataset:
Did a stellar fly-by shape the planetary system around Pr 0211 in the cluster M44?
Authors: Pfalzner Susanne , Bhandare Asmita , Vincke Kirsten 
Published: December 2017

Aims. Out of the ~3000 exoplanets detected so far, only 14 planets are members of open clusters: one of them is the exoplanet system around Pr 0211 in the cluster M44. The system consists of at least 2 planets, and the outer planet moves on a highly eccentric orbit at 5.5 AU. One hypothesis is that a close fly-by of a neighbouring star was responsible for the eccentric orbit. We test this hypothesis.
Methods. First we determined the type of fly-by that would lead to the observed parameters, and then we used this result to determine the history of such fly-bys in simulations of the early dynamics in an M44-like environment.
Results. We find that although very close fly-bys are required to obtain the observed properties of Pr 0211c, such fly-bys are relatively common as a result of the high stellar density and longevity of the cluster. Such close fly-bys are most frequent during the first 1−2 Myr after cluster formation, corresponding to a cluster age ≤3 Myr. During the first 2 to 3 Myr, about 6.5% of stars experience a fly-by that would lead to such a small system-size as observed for Pr 0211 or even smaller. It is unclear whether planets generally form on such short timescales. However, after this time, the close fly-by rate is still 0.2−0.5 Myr−1, which means that 12−20% of stars would experience such close fly-bys over this time span when we extrapolate the situation to the age of M44.
Conclusions. Our simulations show that the fly-by scenario is a realistic option for the formation of eccentricity orbits of the planets in M44 (Wang et al. 2015). The occurrence of such events is relatively high, leading to the expectation that similar systems are likely common in open clusters in general.
Spitzer secondary eclipses of Qatar-1b
Authors: Garhart Emily , Deming Drake , Mandell Avi , Knutson Heather , Fortney Jonathan J. 
Published: December 2017

Aims. Previous secondary eclipse observations of the hot Jupiter Qatar-1b in the Ks band suggest that it may have an unusually high day side temperature, indicative of minimal heat redistribution. There have also been indications that the orbit may be slightly eccentric, possibly forced by another planet in the system. We investigate the day side temperature and orbital eccentricity using secondary eclipse observations with Spitzer.
Methods. We observed the secondary eclipse with Spitzer/IRAC in subarray mode, in both 3.6 and 4.5 μm wavelengths. We used pixel-level decorrelation to correct for Spitzer’s intra-pixel sensitivity variations and thereby obtain accurate eclipse depths and central phases.
Results. Our 3.6 μm eclipse depth is 0.149 ± 0.051% and the 4.5 μm depth is 0.273 ± 0.049%. Fitting a blackbody planet to our data and two recent Ks band eclipse depths indicates a brightness temperature of 1506 ± 71 K. Comparison to model atmospheres for the planet indicates that its degree of longitudinal heat redistribution is intermediate between fully uniform and day-side only. The day side temperature of the planet is unlikely to be as high (1885 K) as indicated by the ground-based eclipses in the Ks band, unless the planet’s emergent spectrum deviates strongly from model atmosphere predictions. The average central phase for our Spitzer eclipses is 0.4984 ± 0.0017, yielding e cos ω = −0.0028 ± 0.0027. Our results are consistent with a circular orbit, and we constrain e cos ω much more strongly than has been possible with previous observations.
Clinical effectiveness of the pocket-creation method for colorectal endoscopic submucosal dissection
Authors: Kanamori Akira , Nakano Masakazu , Kondo Masayuki , Tanaka Takanao , Abe Keiichiro , Suzuki Tsunehiro , Kino Hitoshi , Kaneko Yoshihito , Tsuchida Chieko , Tsuchida Kouhei , Yoshitake Naoto , Tominaga Keiichi , Imai Yasuo , Hiraishi Hideyuki 
Published: December 2017

Abstract
Background and study aims Endoscopic submucosal dissection (ESD) is a technically advanced procedure for colorectal tumors. Hayashi et al. invented the “pocket-creation method (PCM),” and reported that Is-type lesions with fibrosis could be efficaciously and safely resected. However, only case studies have been published, and there are no previous reports on the usefulness of PCM in colorectal ESD for all lesions, as compared with the conventional method. This study aimed to evaluate the effectiveness and safety of PCM in colorectal ESD.
Patients and methods Ninety-six colorectal tumors were treated: 47 using the PCM and the other 49, considered the control group, using the conventional method. Therapeutic effectiveness and safety were retrospectively assessed.
Results The comparison between the PCM and control groups revealed higher rates of en bloc resection (100 % vs. 88 %, P = 0.015) and curative endoscopic resection (100 % vs. 84 %, P = 0.0030) with PCM. There was no significant difference in perforation as an adverse event (AE) between the two groups, though perforation was observed in only 6 % of the control group and none of the PCM group. Compared with the control group, the PCM group had lower incidences of perforation and post-ESD coagulation syndrome, and both AEs were associated with excessive thermal denaturation of the muscle layer (2 % vs. 16 %, P = 0.018).
Conclusions This study demonstrated the effectiveness and safety of ESD with PCM for colorectal tumors. Although there is a possible learning curve, PCM enables the endoscopist to safely perform ESD in most cases without encountering the difficulties associated with conventional ESD.
Factors associated with number of duodenal samples obtained in suspected celiac disease
Authors: Shamban Leonid , Sorser Serge , Naydin Stan , Lebwohl Benjamin , Shukr Mousa , Wiemann Charlotte , Yevsyukov Daniel , Piper Michael , Warren Bradley , Green Peter 
Published: December 2017

Abstract
Background and study aims Many people with celiac disease are undiagnosed and there is evidence that insufficient duodenal samples may contribute to underdiagnosis. The aims of this study were to investigate whether more samples leads to a greater likelihood of a diagnosis of celiac disease and to elucidate factors that influence the number of samples collected.
Patients and methods We identified patients from two community hospitals who were undergoing duodenal biopsy for indications (as identified by International Classification of Diseases code) compatible with possible celiac disease. Three cohorts were evaluated: no celiac disease (NCD, normal villi), celiac disease (villous atrophy, Marsh score 3), and possible celiac disease (PCD, Marsh score < 3). Endoscopic features, indication, setting, trainee presence, and patient demographic details were evaluated for their role in sample collection.
Results 5997 patients met the inclusion criteria. Patients with a final diagnosis of celiac disease had a median of 4 specimens collected. The percentage of patients diagnosed with celiac disease with one sample was 0.3 % compared with 12.8 % of those with six samples (P = 0.001). Patient factors that positively correlated with the number of samples collected were endoscopic features, demographic details, and indication (P = 0.001). Endoscopist factors that positively correlated with the number of samples collected were absence of a trainee, pediatric gastroenterologist, and outpatient setting (P < 0.001).
Conclusions Histological diagnosis of celiac disease significantly increased with six samples. Multiple factors influenced whether adequate biopsies were taken. Adherence to guidelines may increase the diagnosis rate of celiac disease.
Recurrent diffuse gastric bleeding as a leading symptom of gastrointestinal AL amyloidosis
Authors: Franck Caspar , Venerito Marino , Weigt Jochen , Roessner Albert , Malfertheiner Peter 
Published: December 2017

AbstractAmyloidosis is a rare disease (incidence about 0.8/100 000) characterized by extracellular tissue deposition of fibrils composed of low molecular weight subunits of a variety of serum proteins. Clinical manifestations are largely determined by the type of precursor protein, the tissue distribution and the amount of amyloid deposition. Gastrointestinal (GI) manifestations of amyloidosis are even more uncommon (3 % of all amyloidosis patients). Symptoms of GI amyloidosis are nonspecific, heterogeneous, and include weight loss, GI bleeding, heartburn, early satiety, diarrhea and abdominal pain. The histopathological examination of biopsy specimens from the GI tract leads to the diagnosis.Herein we report the case of a 63-year-old woman with recurrent diffuse gastric bleeding. Endoscopic biopsies revealed distinct amyloid deposits in the mucosa of the stomach. Further histochemical assessment confirmed systemic light chain (AL) amyloidosis with clinically predominant gastrointestinal manifestation. An induction therapy with bortezomib and dexamethasone was initiated.Our report illustrates the importance of the multidisciplinary approach for diagnosis and management of AL amyloidosis. Current treatment of systemic AL amyloidosis is based on cytostatic targeting of immunoglobulin producing plasma cells. Therapeutic options are limited and highly toxic, making the development of novel treatment approaches an urgent need.
Facilitating dual careers by improving resistance to chronic stress: effects of an intervention programme for elite student athletes
Authors: Sallen Jeffrey , Hemming Karen , Richartz Alfred 
Published: December 2017

AbstractThe starting point of this contribution is the potential risk to health and performance from the combination of elite sporting careers with the pursuit of education. In European sport science and politics, structural measures to promote dual careers in elite sports have been discussed increasingly of late. In addition to organisational measures, there are calls for educational‐psychological intervention programmes supporting the successful management of dual careers at the individual level. This paper presents an appropriate intervention programme and its evaluation: stress‐resistance training for elite athletes (SRT‐EA). It comprises 10 units, each lasting 90 minutes. It is intended for athletes and aims to improve their resistance to chronic stress. The evaluation was carried out in a quasi‐experimental design, with three points of measurement (baseline, immediately after, and three months after) and two non‐randomised groups: an intervention group (n = 128) and an untreated control group (n = 117). Participants were between 13 and 20 years of age (53.5% male) and represented various Olympic sports. Outcome variables were assessed with questionnaires. Significant short‐ and mid‐term intervention effects were explored. The intervention increased stress‐related knowledge, general self‐efficacy, and stress sensitivity. Chronic stress level, stress symptoms, and stress reactivity were reduced. In line with the intention of the intervention, the results showed short‐ and mid‐term, small to medium‐sized effects. Accordingly, separate measurements at the end of the intervention and three months later showed mostly positive subjective experiences. Thus, the results reinforce the hope that educational‐psychological stress‐management interventions can support dual careers.
Preliminary phytochemical analysis, Antioxidant and cytotoxicity test of Carissa edulis Vahl dried fruits
Authors: Fowsiya J , Madhumitha G 
Published: December 2017

Abstract
Plants are the main source of medicine which is used in traditional as well as modern medicine in recent years for curing many diseases. Carissa edulis Vahl is one of the traditional plants which have healing property on diarrhea, toothache and chest pain. The present work aims on phytochemical, antioxidant and in vitro cytotoxicity test of C. edulis dried fruits. The different solvent extracts obtained from petroleum ether, ethyl acetate, chloroform, ethanol and water have been evaluated the presence of phytochemicals. Several assays were carried out like total antioxidant, DPPH, reducing power and thiobarbituric acid to investigate the free radical scavenging property. In addition, the cytotoxicity study also carried out on human lung cancer cells (A549). Among different solvent extract, ethanol exhibited strong antioxidant activity. Additionally, the in vitro cytotoxicity test of C. edulis on human lung cancer cell (A549) showed IC50 value 405.704 ± 2.42 μg/mL. Therefore, C. edulis could be useful as a potential preventive intervention for free radicals mediated diseases as well as an antioxidant drug in the pharmaceutical industry.
Bilayer tablets of Paliperidone for Extended release osmotic drug delivery
Authors: Sunil Chowdary K , Napoleon A A 
Published: December 2017

Abstract
The purpose of this study is to develop and optimize the formulation of paliperidone bilayer tablet core and coating which should meet in vitro performance of trilayered Innovator sample Invega. Optimization of core formulations prepared by different ratio of polyox grades and optimization of coating of (i) sub-coating build-up with hydroxy ethyl cellulose (HEC) and (ii).enteric coating build-up with cellulose acetate (CA). Some important influence factors such as different core tablet compositions and different coating solution ingredients involved in the formulation procedure were investigated. The optimization of formulation and process was conducted by comparing different in vitro release behaviours of Paliperidone. In vitro dissolution studies of Innovator sample (Invega) with formulations of different release rate which ever close release pattern during the whole 24 h test is finalized.
Synthesis of Novel Isochromen-1-one analogues of Etodolac
Authors: Napoleon A A , Sharma Vijay , Aggile Kadirappa 
Published: December 2017

Abstract
In the present work, anti-inflammatory drug based novel isochromen-1-one, their thio and N-methylated analogues were synthesized from the etodolac bulk drug, 1. All the synthesized compounds were purified and successfully characterized by FT-IR, 1H NMR, 13C NMR and Mass spectroscopy. All the derivatives procured are with remarkable yields from 67-72%.
RETRACTED: Spatial big data for disaster management
Authors: Shalini R , Jayapratha K , Ayeshabanu S , Chemmalar Selvi G 
Published: December 2017

Abstract
Big data is an idea of informational collections that depicts huge measure of information and complex that conventional information preparing application program is lacking to manage them. Presently, big data is a widely known domain used in research, academic, and industries. It is utilized to store substantial measure of information in a solitary brought together one. Challenges integrate capture, allocation, analysis, information precise, visualization, distribution, interchange, delegation, inquiring, updating and information protection. In this digital world, to put away the information and recovering the data is enormous errand for the huge organizations and some time information ought to be misfortune due to circulated information putting away. For this issue the organization individuals are chosen to actualize the huge information to put away every one of the information identified with the organization they are put away in one enormous database that is known as large information. Remote sensor is a science getting data used to distinguish the items or break down the range from a separation. It is anything but difficult to discover the question effortlessly with the sensor. It makes geographic data from satellite and sensor information so in this paper dissect what are the structures are utilized for remote sensor in huge information and how the engineering is vary from each other and how they are identify with our investigations. This paper depicts how the calamity happens and figuring consequence of informational collection. And applied a seismic informational collection to compute the tremor calamity in view of classification and clustering strategy. The classical data mining algorithms for classification used are k-nearest, naive bayes and decision table and clustering used are hierarchical, make density based and simple k_means using XLMINER and WEKA tool. This paper also helps to predicts the spatial dataset by applying the XLMINER AND WEKA tool and thus the big spatial data can be well suited to this paper.
Therapeutic Effects of Lamellar Keratoplasty on Terrien Marginal Degeneration
Authors: Li Lin , Zhai Hualei , Xie Lixin , Cheng Jun , Liu Weiwei 
Published: December 2017

Purpose:To evaluate the therapeutic effects of lamellar keratoplasty (LK) on Terrien marginal degeneration (TMD).Methods:Retrospective interventional case series. Medical records of 63 patients (71 eyes) who received LK for TMD at Qingdao Eye Hospital, Shandong Eye Institute from December 1995 to March 2014 were reviewed. A total of 56 eyes were treated with partial LK and 15 eyes with total LK. Complications, visual acuity recovery, and graft status were evaluated.Results:Mean age of the patients was 50.4 ± 16.8 years. The follow-up period was 2.5 ± 0.9 years. The uncorrected distance visual acuity (UDVA) increased from preoperative 0.90 ± 0.44 logarithm of the minimum angle of resolution (logMAR) to 0.53 ± 0.27 logMAR at 1 year after surgery (t= 16.256,P< 0.001). The corrected distance visual acuity (CDVA) was 0.69 ± 0.30 logMAR preoperatively, and increased to postoperative 0.38 ± 0.22 logMAR (t= −19.982,P< 0.001). After surgery, mean astigmatism was 5.33 ± 2.44 diopters (D) compared with preoperative 10.19 ± 4.32 D (t= 7.351,P< 0.001), and the spherical equivalent decreased from preoperative −2.23 ± 2.34 D to −0.75 ± 2.04 D (t= −2.677,P= 0.012). There was a significant difference in UDVA, ΔUDVA, CDVA, ΔCDVA, and refractive astigmatism between the partial LK and total LK groups. The most common intraoperative complication was corneal perforation. The postoperative complications included double anterior chamber, persistent graft epithelium defects, corneal vascularization, immune rejection, graft ulcers, cataract, and recurrence of marginal degeneration.Conclusions:LK can effectively reduce refractive errors, improve visual acuity, and reduce the risk of corneal perforation for patients with TMD. The visual acuity after partial LK is superior to that after total LK.
Outcomes of Corneal Cross-Linking Correlate With Cone-Specific Lysyl Oxidase Expression in Patients With Keratoconus
Authors: Shetty Rohit , Rajiv Kumar Nimisha , Pahuja Natasha , Deshmukh Rashmi , Vunnava KrishnaPoojita , Abilash Valsala Gopalakrishnan , Roy Abhijit Sinha , Ghosh Arkasubhra 
Published: December 2017

Purpose:
To evaluate the correlation of visual and keratometry outcomes after corneal cross-linking (CXL) in patients with keratoconus with cone epithelium–specific gene expression levels.

Methods:
Corneal epithelium was obtained from 35 eyes that underwent accelerated CXL (KXLII, 9 mW/cm2 for 10 min). Using corneal topography, epithelium over the cone and periphery was obtained separately from each subject. The ratio of gene expression for lysyl oxidase (LOX), matrix metalloproteinase 9 (MMP9), bone morphogenic protein 7, tissue inhibitor of metalloproteinase 1, collagen, type I, alpha 1, and collagen, type IV, alpha 1 (COL IVA1) from the cone and peripheral cornea was correlated with the outcome of cross-linking surgery. Patients were assessed for visual acuity, keratometry, refraction, and corneal densitometry before and 6 months after surgery. Based on the change in corneal flattening indicated by ΔKmax, the outcomes were classified as a higher response or lower response.

Results:
Reduction in keratometric indices correlated with improved spherical equivalent after CXL. Preoperative levels of cone-specific LOX expression in cases with a higher response were significant (P = 0.001). COL IVA1, bone morphogenic protein 7, and tissue inhibitor of metalloproteinase 1 gene expressions were reduced in the cones of the subjects with a lower response. MMP9 levels were relatively lower in cases with a higher response compared with those with a lower response.

Conclusions:
Our study demonstrates that preoperative levels of molecular factors such as LOX, MMP9, and COL IVA1 aid in understanding CXL outcomes at the tissue level.
Skeletal Muscle Mitochondrial Function is Determined by Burn Severity, Sex, and Sepsis, and is Associated With Glucose Metabolism and Functional Capacity in Burned Children
Authors: Rontoyanni Victoria G. , Malagaris Ioannis , Herndon David N. , Rivas Eric , Capek Karel D. , Delgadillo Anahi D. , Bhattarai Nisha , Elizondo Armando , Voigt Charles D. , Finnerty Celeste C. , Suman Oscar E. , Porter Craig 
Published: December 2017

ABSTRACT

Background:
Restoring normal mitochondrial function represents a new target for strategies aimed at mitigating the stress response to severe burn trauma and hastening recovery. Our objective was to investigate the determinants of skeletal muscle mitochondrial respiratory capacity and function and its association with glucose metabolism and functional capacity in burned children.

Methods:
Data from burned children enrolled in the placebo arm of an ongoing prospective clinical trial were analyzed. Mitochondrial respiratory capacity was determined in permeabilized myofibers by high-resolution respirometry on at least one occasion per participant. In subsets of patients, glucose kinetics and cardiorespiratory fitness (VO2peak) were also determined. Mixed multiple regression models were used to identify the determinants of mitochondrial respiratory function and to assess the relationship between mitochondrial respiration and both glucose control and functional capacity (VO2peak).

Main results:
Increasing full-thickness burn size was associated with greater adjusted coupled (ATP-producing) respiration, adjusted for age, sex, sepsis, and time of testing (P < 0.01; n = 55, obs = 97). Girls had on average 23.3% lower coupled respiration (adjusted mean and 95% confidence of interval [CI], −7.1; −12.6 to −1.7 pmol/s/mg; P < 0.025) and 29.8% lower respiratory control than boys (adjusted mean and 95% CI, −0.66; −1.07 to −0.25; P < 0.01; n = 55, obs = 97). The presence of sepsis was associated with lower respiration coupled to ATP production by an average of 25.5% compared with nonsepsis (adjusted mean and 95% CI, −6.9; −13.0 to −0.7 pmol/s/mg; P < 0.05; n = 55, obs = 97), after adjustment for age, sex, full-thickness burn size, and time of testing. During a hyperinsulinemic euglycemic clamp, hepatic glucose release was associated with greater coupled respiration and respiratory control (P < 0.05; n = 42, obs = 73), independent of age, sepsis, full-thickness burn size, and time postinjury testing. Coupled respiration was positively associated with VO2peak after adjustment for age, full-thickness burn size, and time of exercise testing (P < 0.025; n = 18, obs = 25).

Conclusions:
Burn severity, sex, and sepsis influence skeletal muscle mitochondrial function in burned children. Glucose control and functional capacity are associated with altered mitochondrial respiratory function in muscle of burn survivors, highlighting the relationship of altered muscle bioenergetics with the clinical sequelae accompanying severe burn trauma.