bluuebunny/crossref_metadata_2025_split huggingface dataset:
PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine
Authors: Xue Wenda , Wang Wei , Gong Tong , Zhang Hailou , Tao Weiwei , Xue Lihong , Sun Yan , Wang Fushun , Chen Gang 
Published: May 2016

AbstractYueju confers antidepressant effects in a rapid and long-lasting manner, similar to ketamine. CREB (cAMP-response element binding protein) signaling is implicated in depression pathology and antidepressant responses. However, the role of CREB and associated brain derived neurotrophic factor (BDNF) signaling in rapid and long-lasting antidepressant effects remains unclear. Here, we demonstrated that ICR and Kunming strain mice conferred antidepressant responses lasting for 1 and 5 days, respectively, following a single dose of Yueju. One day post Yueju in Kunming but not ICR strain mice, expression of total and phosphorylated CREB, as well as the CREB signaling activator, PKA (protein kinase A) was up-regulated in the hippocampus. Although BDNF gene expression increased at 3 hours in both strains, it remained up-regulated at 1 day only in Kunming mice. Ketamine showed similar strain-dependent behavioral effects. However, blockade of PKA/CREB signaling blunted the antidepressant effects and reversed the up-regulation of BDNF gene expression by Yueju, but not ketamine. Conversely, blockade of mammalian target of rapamycin signaling led to opposite effects. Taken altogether, prolonged transcriptional up-regulation of hippocampal BDNF may account for the stain-dependent enduring antidepressant responses to Yueju and ketamine, but it was mediated via PKA/CREB pathway only for Yueju.
Prevention of antipsychotic-induced hyperglycaemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism
Authors: Nagashima Takuya , Shirakawa Hisashi , Nakagawa Takayuki , Kaneko Shuji 
Published: May 2016

AbstractAtypical antipsychotics are associated with an increased risk of hyperglycaemia, thus limiting their clinical use. This study focused on finding the molecular mechanism underlying antipsychotic-induced hyperglycaemia. First, we searched for drug combinations in the FDA Adverse Event Reporting System (FAERS) database wherein a coexisting drug reduced the hyperglycaemia risk of atypical antipsychotics, and found that a combination with vitamin D analogues significantly decreased the occurrence of quetiapine–induced adverse events relating diabetes mellitus in FAERS. Experimental validation using mice revealed that quetiapine acutely caused insulin resistance, which was mitigated by dietary supplementation with cholecalciferol. Further database analysis of the relevant signalling pathway and gene expression predicted quetiapine-induced downregulation of Pik3r1, a critical gene acting downstream of insulin receptor. Focusing on the phosphatidylinositol 3-kinase (PI3K) signalling pathway, we found that the reduced expression of Pik3r1 mRNA was reversed by cholecalciferol supplementation in skeletal muscle, and that insulin-stimulated glucose uptake into C2C12 myotube was inhibited in the presence of quetiapine, which was reversed by concomitant calcitriol in a PI3K-dependent manner. Taken together, these results suggest that vitamin D coadministration prevents antipsychotic-induced hyperglycaemia and insulin resistance by upregulation of PI3K function.
Metabolomic Response of Skeletal Muscle to Aerobic Exercise Training in Insulin Resistant Type 1 Diabetic Rats
Authors: Dotzert Michelle S. , Murray Michael R. , McDonald Matthew W. , Olver T. Dylan , Velenosi Thomas J. , Hennop Anzel , Noble Earl G. , Urquhart Brad L. , Melling C. W. James 
Published: May 2016

AbstractThe etiology of insulin resistance in Type 1 Diabetes (T1D) is unknown, however it affects approximately 20% of T1D patients. Intramyocellular lipids (IMCL) have been identified as a mechanism of insulin resistance. We examined skeletal muscle of T1D rats to determine if alterations in lipid metabolism were evident and whether aerobic exercise training improves IMCL and insulin resistance. To do so, 48 male Sprague-Dawley rats were divided into control (C), sedentary diabetes (D) and diabetes exercise (DX) groups. Following multiple low-dose Streptozotocin (STZ) injections (20 mg/kg), glycemia (9–15 mM) was maintained using insulin treatment. DX were treadmill trained at high intensity (~75% V02max; 5days/week) for 10 weeks. The results demonstrate that D exhibited insulin resistance compared with C and DX, indicated by decreased glucose infusion rate during a hyperinsulinemic-euglycemic clamp (p < 0.05). There were no differences between C and DX, suggesting that exercise improved insulin resistance (p < 0.05). Metabolomics analysis revealed a significant shift in lipid metabolism whereby notable fatty acid metabolites (arachidonic acid, palmitic acid and several polyunsaturated fatty acids) were significantly elevated in D compared to C and DX. Based on the intermediates observed, insulin resistance in T1D is characterized by an insulin-desensitizing intramyocellular fatty acid metabolite profile that is ameliorated with exercise training.
Highly Sensitive Homogeneous Immunoassays Based on Construction of Silver Triangular Nanoplates-Quantum Dots FRET System
Authors: Zeng Qinghui , Li Qin , Ji Wenyu , Bin Xue , Song Jie 
Published: May 2016

AbstractWith growing concerns about health issues worldwide, elegant sensors with high sensitivity and specificity for virus/antigens (Ag) detection are urgent to be developed. Homogeneous immunoassays (HIA) are an important technique with the advantages of small sample volumes requirement and pretreatment-free process. HIA are becoming more favorable for the medical diagnosis and disease surveillance than heterogeneous immunoassays. An important subset of HIA relies on the effect of fluorescence resonance energy transfer (FRET) via a donor-acceptor (D–A) platform, e.g., quantum dots (QDs) donor based FRET system. Being an excellent plasmonic material, silver triangular nanoplates (STNPs) have unique advantages in displaying surface plasmon resonance in the visible to near infrared spectral region, which make them a better acceptor for pairing with QDs in a FRET-based sensing system. However, the reported STNPs generally exhibited broad size distributions, which would greatly restrict their application as HIA acceptor for high detection sensitivity and specificity purpose. In this work, uniform STNPs and red-emitting QDs are firstly applied to construct FRET nanoplatform in the advanced HIA and further be exploited for analyzing virus Ag. The uniform STNPs/QDs nanoplatform based medical sensor provides a straightforward and highly sensitive method for Ag analysis in homogeneous form.
4.4.21.13 Silylamines (Update 2013)
Authors: Kawachi A. 
Published: May 2016

AbstractThis review, which updates the original Section 4.4.21, published in 2001, discusses the preparation of silylamines bearing dicoordinate, tricoordinate, tetracoordinate, and pentacoordinate silicon centers. Reaction of chlorosilanes with primary or secondary amines is one of the most conventional methods for the syntheses of these compounds. Reactions of halosilanes with lithium amides, lithium β-diketiminates, and other metalated nitrogen species are also useful. A more recent advance is the dehydrogenative condensation of hydrosilanes with primary or secondary amines using transition-metal or Lewis acid catalysts.
5.2.1 Product Subclass 1: Tin Hydrides
Authors: Tchabanenko K. 
Published: May 2016

AbstractThis chapter is a revision of an earlier Science of Synthesis contribution describing methods for the synthesis and synthetic applications of tin hydrides. Synthetic methods based on free-radical chain reactions promoted by tin hydrides are discussed, including cascade reactions that proceed with rearrangement of radical intermediates. Free-radical and transition-metal-catalyzed hydrostannylations of multiple carbon—carbon bonds are also discussed in the chapter.
Creativity, Collaboration and Development in Jeremy Thurlow's Ouija for Peter Sheppard Skærved
Authors: Clarke Eric , Doffman Mark , Timmers Renee 
Published: May 2016

ABSTRACTThis article documents and analyses a creative collaboration between the composer Jeremy Thurlow and the violinist Peter Sheppard Skærved in the production of Ouija, a work for solo violin and laptop computer. The article situates the account of this creative process within recent literature on distributed and collaborative creativity, and focuses on three aspects of the project: verbal interaction between the two musicians, analysed in terms of ‘creative-talk’ and ‘face-talk’, and the relationship between immediate and more contextual concerns (‘inside/outside the room’); a quantitative analysis of changes in the musical material, focusing on timing; and a qualitative analysis of the role of the violinist's embodied and instrumental engagement with the music. The article discusses the findings in relation to forwards-orientated (process) and backwards-orientated (product) conceptions of creativity, the operation of different social components in creative collaboration and the relationship between craft, history and embodiment.
Locating Project Studios and Studio Projects
Authors: Slater Mark 
Published: May 2016

ABSTRACTVia a longitudinal case study of a studio project (Middlewood Sessions, 2004–12), this research explores processes of music-making in the increasingly prevalent context of the project studio to give an insight into contemporary music-making practices. Predicated upon technologies of decreasing size but increasing processing power, project studios represent a diversification of musical creativity in terms of the persons and locations of music production. Increasingly mobile technologies lead to increasingly mobile practices of music production, which presents a challenge to the seemingly simple question: where is the project studio? In response, I propose an ontology of project-studio music-making that sets out what conditions have to be met for location, as an active proposition, to take place.
The Pain Disability Questionnaire (PDQ): evaluation of its utility for presurgical and 1-year postsurgical physical and psychosocial outcomes for patients undergoing total knee arthroplasty
Authors: Howard Krista , Gray Avia , Ramos Stephen , Ellis Henry 
Published: May 2016

Background:
The Pain Disability Questionnaire (PDQ) assesses perception of disability in relation to pain. Past research confirmed the utility of the PDQ to assess treatment outcomes for patients with chronic disabling occupational musculoskeletal disorders. This study evaluates the utility of the PDQ in a sample of patients undergoing total knee arthroplasty (TKA).

Methods:
One hundred and thirty patients with TKA completed the PDQ, along with physical and psychosocial measures before surgery and at 12-months postsurgically. Patients were classified into three groups based on their total baseline PDQ scores: mild/moderate (0-70), severe (71-100), and extreme (101-150). Analyses determined if the PDQ groups were significantly associated with baseline and 12-month postsurgical physical and psychosocial outcomes.

Results:
Patients with severe and/or extreme levels of perceived pain disability were more likely to be younger (P=0.010), Hispanic (P=0.013), and to have no college education (P=0.005). Patients in the extreme group were more likely to have major depressive disorder (P<001), anxiety disorder (P=0.007) and/or somatization disorder (P=0.038). Patients in the severe/extreme groups had higher levels of pain, stiffness, and poor function (all P<0.001) before surgery and greater pain and poorer function 12-months after surgery (all P<0.001). Patients in the extreme group had worse physical and mental quality of life scores at baseline and 12-months after surgery (all P<0.003). Baseline PDQ was significantly associated with both the 12-month postsurgical Western Ontario and McMasters Universities Arthritis index (WOMAC) (P<0.001) and the 12-month postsurgical Short Form-36 (SF-36) mental composite (P<0.001).

Conclusions:
The PDQ is a useful presurgical measure for assessing both baseline and postsurgical physical and psychosocial outcomes for patients undergoing TKA.

Level of Evidence:
Level II, Prospective Cohort Study.
Basic Perforator Flap Hemodynamic Mathematical Model
Authors: Tao Youlun , Ding Maochao , Wang Aiguo , Zhuang Yuehong , Chang Shi-Min , Mei Jin , Tang Maolin , Hallock Geoffrey G. 
Published: May 2016

Background:
A mathematical model to help explain the hemodynamic characteristics of perforator flaps based on blood flow resistance systems within the flap will serve as a theoretical guide for the future study and clinical applications of these flaps.

Methods:
There are 3 major blood flow resistance network systems of a perforator flap. These were defined as the blood flow resistance of an anastomosis between artery and artery of adjacent perforasomes, between artery and vein within a perforasome, and then between vein and vein corresponding to the outflow of that perforasome. From this, a calculation could be made of the number of such blood flow resistance network systems that must be crossed for all perforasomes within a perforator flap to predict whether that arrangement would be viable.

Results:
The summation of blood flow resistance networks from each perforasome in a given perforator flap could predict which portions would likely survive. This mathematical model shows how this is directly dependent on the location of the vascular pedicle to the flap and whether supercharging or superdrainage maneuvers have been added. These configurations will give an estimate of the hemodynamic characteristics for the given flap design.

Conclusions:
This basic mathematical model can (1) conveniently determine the degree of difficulty for each perforasome within a perforator flap to survive; (2) semiquantitatively allow the calculation of basic hemodynamic parameters; and (3) allow the assessment of the pros and cons expected for each pattern of perforasomes encountered clinically based on predictable hemodynamic observations.
Gelling Your Dermatology Nursing Practice
Authors: McCann Sue A. , Chase Allister Benjamin , Tawa Marianne C. 
Published: May 2016

ABSTRACTMycosis fungoides is the most common form of cutaneous T-cell lymphoma. Stage IA and IB mycosis fungoides cutaneous T-cell lymphoma can be effectively controlled by skin-directed therapies such as the mechlorethamine gel approved by the Food and Drug Administration. Dermatology nurses play a key role in promoting good patient compliance through patient education about mycosis fungoides cutaneous T-cell lymphoma disease, proper administration of mechlorethamine gel, and connecting patients with patient assistance programs or other supportive services. This article provides the dermatology nurse with a background about early-stage mycosis fungoides cutaneous T-cell lymphoma, skin-directed treatment options, questions that a patient may ask about mycosis fungoides cutaneous T-cell lymphoma and mechlorethamine gel, and patient education tools such as questions dermatology nurses may ask of their patients and a patient handout outlining mechlorethamine gel administration.
The evolution of coercive policing in genetically mixed groups: the case of plasmid copy number control
Authors: Kentzoglanakis Kyriakos , Brown Sam P. , Goldstein Richard A. 
Published: May 2016

AbstractPolicing is a widespread mechanism regulating cooperation in both human and animal social groups. Policing can promote the evolution and maintenance of cooperation among non-relatives by tying the reproductive success of individuals to the efficiency and success of the group. In this paper, we investigate the evolution of reproductive policing using a multi-scale computational model inspired by the copy number control system of conjugative bacterial plasmids. Our results show that the repression of competition through policing can evolve across a very broad range of migration (plasmid conjugation) rates, improving system-level performance and bringing efficiency gains to the group beyond those achievable by pure self-restraint. Reproductive policing acts to increase genetic relatedness by reducing variation in group size which, in turn, reduces the heterogeneity of the plasmid population. When among-group migration is high, coercive policing strategies are favoured, characterized by high levels of policing coupled with relatively lower obedience. Coercive policing strategies preferentially limit the reproduction of rival lineages while, at the same time, maintaining effective collective reproductive control.Author SummaryThe emergence and maintenance of cooperation is a topic of great importance in evolutionary biology. The evolution of cooperation has been explained in the context of kin selection when there is sufficient genetic relatedness among interacting individuals. When there is insufficient relatedness, the presence of alternative mechanisms, such as mutual policing, can promote the evolution and maintenance of cooperation by tying the reproductive success of individual to the efficiency and success of the group. In this paper, we investigate the evolution of reproductive policing using an agent-based computational model inspired by a simple and elegant biological example: replication control among conjugative plasmids, a class of molecular symbionts of bacterial hosts. Our results show that the repression of competition through policing evolves and improves plasmid group performance beyond levels achievable by self-restraint, across a very broad range of migration rates. Under conditions of high migration (frequent conjugation), we observe the evolution of coercive policing strategies that limit the reproduction of rival lineages by investing disproportionately in policing relative to their obedience to the policing trait.
Parvalbumin interneuron dysfunction in a thalamus - prefrontal cortex circuit in Disc1 deficiency mice
Authors: Delevich Kristen , Jaaro-Peled Hanna , Penzo Mario , Sawa Akira , Li Bo 
Published: May 2016

AbstractTwo of the most consistent findings across disrupted-in-schizophrenia-1 (DISC1) mouse models are impaired working memory and reduced number or function of parvalbumin interneurons within the prefrontal cortex. While these findings suggest parvalbumin interneuron dysfunction in DISC1-related pathophysiology, to date, cortical inhibitory circuit function has not been investigated in depth in DISC1 deficiency mouse models. Here we assessed the function of a feedforward circuit between the mediodorsal thalamus (MD) and the medial prefrontal cortex (mPFC) in mice harboring a deletion in one allele of the Disc1 gene. We found that the inhibitory drive onto layer 3 pyramidal neurons in the mPFC was significantly reduced in the Disc1 deficient mice. This reduced inhibition was accompanied by decreased GABA release from local parvalbumin, but not somatostatin, inhibitory interneurons, and by impaired feedforward inhibition in the MD-mPFC circuit. Our results reveal a cellular mechanism by which deficiency in DISC1 causes neural circuit dysfunction frequently implicated in psychiatric disorders.
The LifeMatters programme for developing life-skills in children: an evaluation
Authors: O'Rourke Margaret , Hammond Sean , O'Sullivan David , Staunton Ciara , O'Brien Siobhan 
Published: May 2016

Purpose– LifeMatters is a cognitive behavioural coaching programme that provides tools and techniques for developing and applying five areas of life skill competency: taking care of the body, feeling positive, thinking wisely, acting wisely, and taking care of the spirit. The purpose of paper is to evaluate the viability of the LifeMatters programme with a cohort of secondary school students (12-15 years) in Ireland.Design/methodology/approach– Open-ended feedback obtained from 196 participants who completed an open-ended questionnaire. These responses were subjected to a thematic analysis. Subsequent quantitative analysis of the resulting categorical data were carried out using correspondence analysis.Findings– Categorical analysis produced statistically significant sex and age differences showing that males and females differed in their experience of the programme. Girls benefited more from a focus upon stress and self-confidence whereas boys benefited more from a focus on relationship building.Originality/value– This study demonstrates the viability of the LifeMatters programme for secondary school students as an aid to develop life skills. It highlights the different needs of boys and girls in this area.
The relevance of credit ratings over the business cycle
Authors: Fieberg Christian , Mertens Richard Lennart , Poddig Thorsten 
Published: May 2016

Purpose
Credit market models and the microstructure theory of the ratings market suggest that information provided by credit rating agencies becomes more relevant in recessions when agency costs are high and less relevant in expansions when agency costs are low. The purpose of this paper is to empirically test these hypotheses with regard to equity markets.

Design/methodology/approach
The authors use business cycle identification algorithms to map rating events (credit rating changes and watchlist inclusions) to business cycle phases and apply the event study methodology. The results are backed by cross-sectional regressions using a variety of control variables.

Findings
The authors find that the relevance of information provided by credit rating agencies for equity prices heavily depends on the level of agency costs. Furthermore, the authors detect a “flight-to-quality” during recessions in the speculative grade segment and a weakened relevance of rating events in expansions in the investment grade segment.

Originality/value
This paper is the first to empirically analyse how equity investors perceive credit rating changes and watchlist inclusions over the business cycle. In the empirical analysis, the authors use a large sample of about 25,000 rating events in all Organisation for Economic Co-operation and Development markets. The presented results underline that credit ratings address the agency problem in financial markets and can thus be regarded as useful for risk management or regulation.
Survival analysis of supply chain financial risk
Authors: Dellana Scott , West David 
Published: May 2016

PurposeThe purpose of this paper is to apply survival analysis, using Cox proportional hazards regression (CPHR), to the problem of predicting if and when supply chain (SC) customers or suppliers might file a petition for bankruptcy so that proactive steps may be taken to avoid a SC disruption.Design/methodology/approachCPHR is first compared to multiple discriminant analysis (MDA) and logistic regression (LR) to assess its suitability and accuracy to SC applications using three years of financial quarterly data for 69 non-bankrupt and 74 bankrupt organizations. A k-means clustering approach is then applied to the survival curves of all 143 organizations to explore heuristics for predicting the timing of bankruptcy petitions.FindingsCPHR makes bankruptcy predictions at least as accurately as MDA and LR. The survival function also provides valuable information on when bankruptcy might occur. This information allows SC members to be prioritized into three groups: financially healthy companies of no immediate risk, companies with imminent risk of bankruptcy and companies with intermediate levels of risk that need monitoring.Originality/valueThe current paper proposes a new analytical approach to scanning and assessing the financial risk of SC members (suppliers or customers). Traditional models are able to predict if but not when a financial failure will occur. Lacking this information, it is impossible for SC managers to prioritize risk mitigation activities. A simple decision rule is developed to guide SC managers in setting these priorities.