bluuebunny/crossref_metadata_2025_split huggingface dataset:
New anti-resorptives and antibody mediated anti-resorptive therapy
Authors: Farrier A. J. , C. Sanchez Franco L. , Shoaib A. , Gulati V. , Johnson N. , Uzoigwe C. E. , Choudhury M. Z. 
Published: February 2016

The ageing population and an increase in both the incidence and prevalence of cancer pose a healthcare challenge, some of which is borne by the orthopaedic community in the form of osteoporotic fractures and metastatic bone disease. In recent years there has been an increasing understanding of the pathways involved in bone metabolism relevant to osteoporosis and metastases in bone. Newer therapies may aid the management of these problems. One group of drugs, the antibody mediated anti-resorptive therapies (AMARTs) use antibodies to block bone resorption pathways. This review seeks to present a synopsis of the guidelines, pharmacology and potential pathophysiology of AMARTs and other new anti-resorptive drugs. We evaluate the literature relating to AMARTs and new anti-resorptives with special attention on those approved for use in clinical practice. Denosumab, a monoclonal antibody against Receptor Activator for Nuclear Factor Kappa-B Ligand. It is the first AMART approved by the National Institute for Health and Clinical Excellence and the US Food and Drug Administration. Other novel anti-resorptives awaiting approval for clinical use include Odanacatib. Denosumab is indicated for the treatment of osteoporosis and prevention of the complications of bone metastases. Recent evidence suggests, however, that denosumab may have an adverse event profile similar to bisphosphonates, including atypical femoral fractures. It is, therefore, essential that orthopaedic surgeons are conversant with these medications and their safe usage. Take home message: Denosumab has important orthopaedic indications and has been shown to significantly reduce patient morbidity in osteoporosis and metastatic bone disease. Cite this article: Bone Joint J 2016;98-B:160–5.
Cost analysis of the surgical treatment of fractures of the proximal humerus
Authors: Sabharwal S. , Carter A. W. , Rashid A. , Darzi A. , Reilly P. , Gupte C. M. 
Published: February 2016

Aims The aims of this study were to estimate the cost of surgical treatment of fractures of the proximal humerus using a micro-costing methodology, contrast this cost with the national reimbursement tariff and establish the major determinants of cost. Methods A detailed inpatient treatment pathway was constructed using semi-structured interviews with 32 members of hospital staff. Its content validity was established through a Delphi panel evaluation. Costs were calculated using time-driven activity-based costing (TDABC) and sensitivity analysis was performed to evaluate the determinants of cost Results The mean cost of the different surgical treatments was estimated to be £3282. Although this represented a profit of £1138 against the national tariff, hemiarthroplasty as a treatment choice resulted in a net loss of £952. Choice of implant and theatre staffing were the largest cost drivers. Operating theatre delays of more than one hour resulted in a loss of income Discussion Our findings indicate that the national tariff does not accurately represent the cost of treatment for this condition. Effective use of the operating theatre and implant discounting are likely to be more effective cost containment approaches than control of bed-day costs. Take home message: This cost analysis of fractures of the proximal humerus reinforces the limitations of the national tariff within the English National Health Service, and underlines the importance of effective use of the operating theatre, as well as appropriate implant procurement where controlling costs of treatment is concerned. Cite this article: Bone Joint J 2016;98-B:249–59.
Surgical hip dislocation according to Ganz for excision of osteochondromas in patients with multiple hereditary exostoses
Authors: Sorel J. C. , Façee Schaeffer M. , Homan A. S. , Scholtes V. A. B. , Kempen D. H. R. , Ham S. J. 
Published: February 2016

Aims We report a prospective cohort study of the midterm results of surgical dislocation of the hip (according to Ganz) to perform resection of osteochondromas involving the femoral neck in patients with multiple hereditary exostoses (MHE). Methods Hip range of movement (ROM) was assessed pre- and post-operatively. Patients’ judgment of post-operative reduction of pain, symptoms, the Rand 36-item Health Survey (RAND-36) and complications were analysed. Results Symptomatic osteochondromas of the femoral neck were removed in 20 hips (17 patients) between 2007 and 2012. There were nine men and eight women with a mean age at the time of surgery of 29 years (11 to 47). Mean follow-up was 46 months (26 to 73). At latest follow-up, mean ROM was significantly increased in all directions. Post-operatively the pain associated with the lesion was either significantly decreased or non-existent. There was a significant improvement in seven RAND-36 sub-domains. Encountered complications in four patients were pseudoarthrosis of the trochanteric osteotomy, traumatic separation of the trochanteric osteotomy, a pertrochanteric femoral fracture and avasvular necrosis. Histological analysis revealed osteochondromas in all hips. Discussion This study confirms the Ganz trochanteric flip osteotomy provided a reliable approach to osteochondromas of the femoral neck that are otherwise difficult to access for surgical resection. The procedure offered significant improvement in the quality of life, although one should be aware of the serious complications can arise despite the relatively safe procedure. Take home message: When daily function and activities are affected, resection of osteochondromas of the proximal femur according to Ganz is indicated to significantly improve quality of life. Cite this article: Bone Joint J 2016;98-B:260–5.
The impact of including corticosteroid in a periarticular injection for pain control after total knee arthroplasty
Authors: Tsukada S. , Wakui M. , Hoshino A. 
Published: February 2016

There is conflicting evidence about the benefit of using corticosteroid in periarticular injections for pain relief after total knee arthroplasty (TKA). We carried out a double-blinded, randomised controlled trial to assess the efficacy of using corticosteroid in a periarticular injection to control pain after TKA.A total of 77 patients, 67 women and ten men, with a mean age of 74 years (47 to 88) who were about to undergo unilateral TKA were randomly assigned to have a periarticular injection with or without corticosteroid. The primary outcome was post-operative pain at rest during the first 24 hours after surgery, measured every two hours using a visual analogue pain scale score. The cumulative pain score was quantified using the area under the curve.The corticosteroid group had a significantly lower cumulative pain score than the no-corticosteroid group during the first 24 hours after surgery (mean area under the curve 139, 0 to 560, and 264, 0 to 1460; p = 0.024). The rate of complications, including surgical site infection, was not significantly different between the two groups up to one year post-operatively.The addition of corticosteroid to the periarticular injection significantly decreased early post-operative pain. Further studies are needed to confirm the safety of corticosteroid in periarticular injection.Take home message: The use of corticosteroid in periarticular injection offered better pain relief during the initial 24 hours after TKA.Cite this article: Bone Joint J 2016;98-B:194–200.
Cost effectiveness of surgical versus non-surgical treatment of adults with displaced fractures of the proximal humerus
Authors: Corbacho B. , Duarte A. , Keding A. , Handoll H. , Chuang L. H. , Torgerson D. , Brealey S. , Jefferson L. , Hewitt C. , Rangan A. 
Published: February 2016

Aims A pragmatic multicentre randomised controlled trial (PROFHER) was conducted in United Kingdom National Health Service (NHS) hospitals to evaluate the clinical effectiveness and cost effectiveness of surgery compared with non-surgical treatment for displaced fractures of the proximal humerus involving the surgical neck in adults. Methods A cost utility analysis from the NHS perspective was performed. Differences between surgical and non-surgical treatment groups in costs and quality adjusted life years (QALYs) at two years were used to derive an estimate of the cost effectiveness of surgery using regression methods. Results Patients randomised to receive surgical intervention accumulated mean greater costs and marginally lower QALYs than patients randomised to non-surgery. The surgical intervention cost a mean of £1758 more per patient (95% confidence intervals (CI) £1126 to £2389). Total QALYs for the surgical group were smaller than those for non-surgery -0.0101 (95% CI -0.13 to 0.11). The probability of surgery being cost effective was less than 10% given the current NICE willingness to pay at a threshold of £20 000 for an additional QALY. The results were robust to sensitivity analyses. Discussion The results suggest that current surgical treatment is not cost effective for the majority of displaced fractures of the proximal humerus involving the surgical neck in the United Kingdom’s NHS. Take home message: The results of this trial do not support the trend of increased surgical treatment for patients with displaced fractures of the proximal humerus involving the surgical neck within the United Kingdom NHS. Cite this article: Bone Joint J 2016;98-B:152–9.
Guidelines for reporting health economic research
Authors: Haddad F. S. , McLawhorn A. S. 
Published: February 2016

Health economic evaluations potentially provide valuable information to clinicians, health care administrators, and policy makers regarding the financial implications of decisions about the care of patients. The highest quality research should be used to inform decisions that have direct impact on the access to care and the outcome of treatment. However, economic analyses are often complex and use research methods which are relatively unfamiliar to clinicians. Furthermore, health economic data have substantial national, regional, and institutional variability, which can limit the external validity of the results of a study. Therefore, minimum guidelines that aim to standardise the quality and transparency of reporting health economic research have been developed, and instruments are available to assist in the assessment of its quality and the interpretation of results. The purpose of this editorial is to discuss the principal types of health economic studies, to review the most common instruments for judging the quality of these studies and to describe current reporting guidelines. Recommendations for the submission of these types of studies to The Bone & Joint Journal are provided. Cite this article: Bone Joint J 2016;98-B:147–51.
Prognostic Value of Serial Changes in High-Sensitivity Cardiac Troponin I and T over 3 Months Using Reference Change Values in Hemodialysis Patients
Authors: Sandoval Yader , Herzog Charles A , Love Sara A , Cao Jing , Hu Yan , Wu Alan H B , Gilbertson David , Brunelli Steven M , Young Amy , Ler Ranka , Apple Fred S 
Published: February 2016

AbstractINTRODUCTIONSerial changes in cardiac troponin in hemodialysis (HD) patients have uncertain clinical implications. We evaluated associations of adverse outcomes in HD patients with reference change value (RCV) data and tertile concentrations for cardiac troponin I (cTnI) and cTnT measured by high-sensitivity (hs) assays.METHODSRCV data and tertiles for hs-cTnI and hs-cTnT were determined from plasma samples collected 3 months apart in 677 stable outpatient HD patients and assessed for their associations with adverse outcomes using adjusted Cox models. Primary outcomes were all-cause mortality and sudden cardiac death (SCD).RESULTSDuring a median follow-up of 23 months, 18.6% of patients died. RCVs were: hs-cTnI +37% and −30%; hs-cTnT +25% and −20%. Patients with serial hs-cTnI and hs-cTnT changes &gt;RCV (increase or decrease) had all-cause mortality of 25.2% and 23.8% respectively, compared to 15.0% and 16.5% with changes ≤RCV [adjusted hazard ratios (aHRs): 1.9, P = 0.0003 and 1.7, P = 0.0066), respectively]. Only hs-cTnI changes &gt;RCV were predictive of SCD (aHR 2.6, P = 0.005). hs–Cardiac troponin changes &gt;RCV improved all-cause mortality prognostication compared to changes ≤RCV in tertile 2: hs-cTnI aHR, 2.70 (P = 0.003); hs-cTnT aHR, 1.98 (P = 0.043). The aHR of changes in hs-cTnI in tertile 2 &gt;RCV for SCD was 5.62 (P = 0.039).CONCLUSIONSChanges over 3 months in hs-cTnI and hs-cTnT of &gt;RCV identified patients at greater risk of all-cause mortality, and for hs-cTnI were also predictive of SCD. Among patients with middle tertile cardiac troponin concentrations, hs-cTnI changes &gt;RCV provided additive prognostic value for both SCD and all-cause mortality, whereas those for hs-cTnT provided additive prognostic value only for all-cause mortality.
20. The Effect of Muscle Type and Time of Storage on Myofibrillar Protein Proportion in Beef
Authors: Zając Marzena , Palka Krystyna , Mikołajczak Beata , Pospiech Edward 
Published: February 2016

Abstract
Tenderness is usually associated with the proteolysis occurring in muscles. However, most of the studies concentrate on one muscle only. The aim of this study was to describe the changes in myofibrillar protein percentage proportions during the ageing of 8 bovine muscles. Investigations were conducted on the muscles from different parts of the carcass, from the forequarter: m. pectoralis profundus, m. infraspinatus, m. triceps brachii, m. serratus ventralis, and from the hindquarter: m. biceps femoris, m. semimembranosus, m. semitendinosus and m. longissimus dorsi (thoracis et lumborum). The effect of muscle type was significant for all parameters except for percentage proportions of titin (3000÷3700 kDa), MHC (205 kDa) and protein fractions between <205÷42> kDa. Differences between the muscles varied depending on the analysed proteins and the time of storage. A significant effect of ageing time for titin, nebulin (approx. 800 kDa), proteins of molecular weight of 38 kDa, proteins smaller than 42 kDa and in the range of 3000÷205 kDa, 205÷42 kDa and 38÷20 kDa was observed. The decrease of percentage proportions of titin, nebulin and proteins in the range of 3000÷205 kDa and an increase of protein bands in the range of 38÷20 kDa and proteins below 42 kDa was also observed. During the storage period of beef from the 2nd to the 14th day, the progress of myofibrillar proteolysis was different in each muscle. The changes of tenderness were not related to shear force values. It is probable that the changes in other constituents of meat might influence the tenderness more than those in myofibrillar proteins.
16. Effect of Diet Supplemented with Antioxidants (Selenium, Copper, Vitamins E and C) on Antioxidant Status and Ejaculate Quality of Breeding Boars
Authors: Horký Pavel , Skladanka Jiri , Nevrkla Pavel , Slama Petr 
Published: February 2016

Abstract
The aim of the experiment was to determine the effect of selected antioxidants (selenium, copper, vitamins E and C) on the antioxidant status of breeding boar ejaculate and ejaculate quality. In the first control group of boars (n = 10), the amount of antioxidants was not increased in feed. The second experimental group (n = 10) received the addition of selenium (0.5 mg/kg of diet), copper (10 mg/kg of diet), vitamin C (350 mg/kg of diet) and vitamin E (70 mg/kg of diet) in feed. The experiment lasted for 90 days. The addition of antioxidants increased GPx (by 28%), selenium content (by 49%; P<0.05), SOD (by 9%; P<0.05) and level of copper (by 63%; P<0.05) in the experimental group of boars. In the control group, the decrease of sperm motility (by 22%; P<0.05) was found at the end of the experiment. Other measured parameters such as ABTS antioxidant capacity, levels of MDA, metallothionein, zinc, ejaculate volume, concentration, total count of sperm and percentage of abnormal sperm cells were not significantly affected. The above mentioned results show that the addition of antioxidants does not increase the ejaculate quality but their lack can damage the quality indicators of boar ejaculate.
Motivation, Stress and Learning – Critical Characteristics that Influence the Horses’ Value and Training Method – A Review
Authors: Olczak Katarzyna , Nowicki Jacek , Klocek Czesław 
Published: February 2016

Abstract
Equine husbandry is carried out in an environment unnatural to horses, which enforces their adaptation to artificial conditions. Besides housing conditions, the management and human-horse relationship is very important for both human safety and a high level of animal welfare and performance. This would not be possible if horses were not able to learn. For equestrians, independently of the horse’s use (sport, work, recreation, therapy etc.) the performance is of the highest importance. Deep knowledge about learning mechanisms is essential to maintain high level of horses’ welfare and to achieve effective training. Cognition can be influenced by motivation and stress. Motivational mechanisms are based on positive or negative reinforcement but still it is not known what motivates horses more and how food motivation influences learning. It was already shown that a low level of motivation decreases animal performance. The effect of stress is an increasingly popular research topic. It has been shown that acute stress decreases horses’ learning performance, but the exact standard is still unknown. The Yerkes-Dodson law claims that low and too high arousal decreases learning. What is more, the relation between learning and sex, breed and some temperamental traits has been shown in several studies.
PAH and PCB Levels in Malva sylvestris L. Specimens Collected from Kocaeli, Turkey
Authors: Terzi Mine , Acemi Arda , Ergül Halim Aytekin , Özen Fazıl 
Published: February 2016

Abstract:In this study, polycyclic aromatic hydrocarbon (PAH) and polychlorinated biphenyl (PCB) contaminations in the leaf, stem and root tissues of common mallow (
Impact of wastewater application on magnetic susceptibility in Terric Histosol soil
Authors: Sokołowska Zofia , Alekseev Andrey , Skic Kamil , Brzezińska Małgorzata 
Published: February 2016

Abstract
In this work, we attempted to analyse the changes in magnetic susceptibility in Terric Histosol soil irrigated with municipal wastewater in a period of four years. Effects of different plants (poplar and willow), wastewater doses, depths, as well as the concentration of the elements and the total carbon content were tested. The study showed that systematic wastewater irrigation diminished magnetic susceptibility values in the top layer of soil. However, statistical analysis revealed that both doses of wastewater and growing plants did not have a significant impact on the magnetic susceptibility of obtained results. Magnetic susceptibility decreased significantly with the depth, in accordance with higher total carbon and lower content of magnetic particles. High correlation coefficients were found between magnetic susceptibility and Zn, Al2O3, Fe2O3, MnO content, whereas no correlation was observed for Cr, as well as for Pb.
Green ultrasound-assisted extraction of anthocyanin and phenolic compounds from purple sweet potato using response surface methodology
Authors: Zhu Zhenzhou , Guan Qingyan , Guo Ying , He Jingren , Liu Gang , Li Shuyi , Barba Francisco J. , Jaffrin Michel Y. 
Published: February 2016

AbstractResponse surface methodology was used to optimize experimental conditions for ultrasound-assisted extraction of valuable components (anthocyanins and phenolics) from purple sweet potatoes using water as a solvent. The Box-Behnken design was used for optimizing extraction responses of anthocyanin extraction yield, phenolic extraction yield, and specific energy consumption. Conditions to obtain maximal anthocyanin extraction yield, maximal phenolic extraction yield, and minimal specific energy consumption were different; an overall desirability function was used to search for overall optimal conditions: extraction temperature of 68ºC, ultrasonic treatment time of 52 min, and a liquid/solid ratio of 20. The optimized anthocyanin extraction yield, phenolic extraction yield, and specific energy consumption were 4.91 mg 100 g−1fresh weight, 3.24 mg g−1fresh weight, and 2.07 kWh g−1, respectively, with a desirability of 0.99. This study indicates that ultrasound-assisted extraction should contribute to a green process for valorization of purple sweet potatoes.
Influence of the crystalline structure of cellulose on the production of ethanol from lignocellulose biomass
Authors: Smuga-Kogut Małgorzata , Zgórska Kazimiera , Szymanowska-Powałowska Daria 
Published: February 2016

Abstract
In recent years, much attention has been devoted to the possibility of using lignocellulosic biomass for energy. Bioethanol is a promising substitute for conventional fossil fuels and can be produced from straw and wood biomass. Therefore, the aim of this paper was to investigate the effect of 1-ethyl-3-methylimidazolium pretreatment on the structure of cellulose and the acquisition of reducing sugars and bioethanol from cellulosic materials. Material used in the study was rye straw and microcrystalline cellulose subjected to ionic liquid 1-ethyl-3-methylimidazolium pretreatment. The morphology of cellulose fibres in rye straw and microcrystalline cellulose was imaged prior to and after ionic liquid pretreatment. Solutions of ionic liquid-treated and untreated cellulosic materials were subjected to enzymatic hydrolysis in order to obtain reducing sugars, which constituted a substrate for alcoholic fermentation. An influence of the ionic liquid on the cellulose structure, accumulation of reducing sugars in the process of hydrolysis of this material, and an increase in ethanol amount after fermentation was observed. The ionic liquid did not affect cellulolytic enzymes negatively and did not inhibit yeast activity. The amount of reducing sugars and ethyl alcohol was higher in samples purified with 1-ethyl-3-methy-limidazolium acetate. A change in the supramolecular structure of cellulose induced by the ionic liquid was also observed.
Expansion in chickpea (Cicer arietinum L.) seed during soaking and cooking
Authors: Sayar Sedat , Turhan Mahir , Köksel Hamit 
Published: February 2016

AbstractThe linear and volumetric expansion of chickpea seeds during water absorption at 20, 30, 50, 70, 85 and 100°C was studied. Length, width and thickness of chickpea seeds linearly increased with the increase in moisture content at all temperatures studied, where the greatest increase was found in length. Two different mathematical approaches were used for the determination of the expansion coefficients. The plots of the both linear and volumetric expansion coefficients versus temperature exhibited two linear lines, the first one was through 20, 30 and 50ºC and the second one was trough 70, 85 and 100ºC. The crossing point (58ºC) of these lines was very close to the gelatinisation temperature (60ºC) of chickpea starch.