bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDI HUBUNGAN KUANTITATIF STRUKTUR AKTIVITAS SENYAWA TURUNAN MEISOINDIGO SEBAGAI INHIBITOR CDK4
Authors: Arba Muhammad , Andriansyah Riki , Leonita Messi 
Published: December 2017

ABSTRAKTelah dilakukan analisis Hubungan Kuantitatif Struktur-Aktivitas (HKSA) senyawa turunan meisoindigo sebagai inhibitor Cyclin Dependent Kinase-4 (CDK4) menggunakan regresi multi linear untuk pemilihan variabel. Hasil penelitian menyatakan bahwa aktivitas penghambatan CDK4 dari senyawa turunan mesoindigo bergantung pada beberapa parameter, yaitu momen dipol, energi total, energi elektronik, panas pembentukan, dan kelarutan. Akurasi model HKSA yang diusulkan divalidasi baik dengan teknik validasi silang maupun dengan validasi eksternal. Hasil penelitian ini dapat digunakan untuk desain senyawa inhibitor CDK4 yang lebih baik dari turunan meisoindigo. Kata kunci: HKSA, meisoindigo, kanker, CDK4 ABSTRACTCyclin-dependent kinase 4 (CDK4) is an important target in the treatment of cancer. Exploring of compounds that can inhibit the activity of CDK4 is actively performed worldwide. This research was conducted to do Quantitative Structure-Activity Relationship (QSAR) analysis of meisoindigo derivative compounds as inhibitor for CDK4 in order to get QSAR equation, then it was further used to design new inhibitor based meisoindigo which has more potent and selective for CDK4. Data compound is divided into training set to build QSAR models and the test set to validate the model. Calculation was done by MOE2009.10 descriptor and multilinear regression analysis, SPSS19.0. The results showed that the inhibitory activity of mesoindigo derived compounds toward CDK4 was depended on several dipole moment, total energy, electronic energy, heat of formation, and solubility. The accuracy of QSAR models proposed validated by cross validation techniques and with external validation. The results of this study can be used to design a new CDK4 inhibitor compound better than meisoindigo derivative Keywords: QSAR, meisoindigo, cancer, CDK4
Silika pada Togkol Jagung yang Dikarakterisasi Menggunakan Spektroskopi Infra Merah dan Difraksi Sinar-X
Authors: Wardhani Gladys Ayu paramita kusumah 
Published: December 2017

Penelitian ini dilakukan untuk mengisolasi silika pada tongkol jagung menggunakan HCl dengan variasi suhu perendaman. Silika yang diperoleh dikarakterisasi ikatan dan strukturnya menggunakan spektroskopi infra merah dan difraksi sinar-X. Silika dari serbuk tongkol jagung diperoleh dengan cara nontermal melalui perendaman dengan HCl pada suhu kamar dan suhu 60˚C selama 3 jam dan cara termal melalui pembakaran pada suhu 800˚C. Silika yang diperoleh dikarakterisasi ikatannya dan diperoleh pita serapan karakteristik silika muncul pada bilangan gelombang 1101, 794, dan 468 cm-1. Struktur silika yang dikarakterisasi menggunakan difraktometer sinar-X menunjukkan fase amorf silika pada 2θ˚ = 21 - 25ᵒ dan mulai terbentuk fase kristalin pada 2θ˚ = 26ᵒ. Kata Kunci : silika dari tongkol jagung, spektra FT-IR, difraktogram XRD
SINTESIS DAN KARAKTERISASI SENYAWA KOMPLEKS Zn(II)-EDTA SEBAGAI SENAYAWA ANTIALGA PADA COOLING WATER INDUSTRI
Authors: Setyawati Harsasi 
Published: December 2017

ABSTRACTA research on the synthesis and characterization of complex compounds of Zn (II)-EDTA as antialgae compound is applied to the cooling water industry. This research aims to determine the activity of complex compounds of Zn (II)-EDTA against algae that live in the water cooling water. The activity antialgae assay of comple compound of Zn(II)-EDTA with luminescence method and dry cell weight method. Complex compound of Zn (II)-EDTA made with mole ratio of ZnCl2: Na2EDTA is 1:1. Complex compound of Zn (II)-EDTA analyzed using UV-Vis spectrophotometer and FTIR spectrophotometer. The results of UV-Vis spectrophotometer analysis showed that the complex compounds of Zn (II)-EDTA has a maximum wavelength at 752 nm. While the results of FTIR analysis showed Zn-O vibration absorption at wave number 478.35 cm-1 and Zn-N vibration absorption at wave number 516.92 cm-1. In the activity antialgae assay of complex compound of Zn (II)-EDTA made with a concentration of 5 ppm, 10 ppm, 50 ppm and 100 ppm. The test results showed that the activity of complex compounds of Zn (II) -EDTA can kill green algae and brown algae. Of the four concentrations of complex compounds of Zn (II)-EDTA, green algae and brown algae can be killed optimally at a concentration of 50 ppm.Keywords: complex Zn(II)-EDTA, cooling water, antialgae, green algae, brown algae
Macroscale Mechanical and Microscale Structural Changes in Chinese Wufeng Shale With Supercritical Carbon Dioxide Fracturing
Authors: Liu Qing-You , Tao Lei , Zhu Hai-Yan , Lei Zheng-Dong , Jiang Shu , McLennan John David 
Published: December 2017

Summary
Waterless fracturing for shale-gas exploitation using supercritical carbon dioxide (scCO2) is both effective and environmentally friendly, and has become an extensive research topic. Previous researchers have focused on the chemical and physical properties and microstructure of sandstone, carbonate, and shale caprock, rather than on the properties of shale-gas formations. The macroscale mechanical properties and microscale fracture characteristics of Wufeng Shale exposed to scCO2 (at greater than 31.8°C and 7.29 MPa) are still not well-understood. To study the macroscale and microscale changes of shale subjected to scCO2, we obtained Chinese Wufeng Shale crops (Upper Ordovician Formation) from Yibin, Sichuan Basin, China. The shale samples were divided into two groups. The first group was exposed to scCO2, and the second group was exposed to nitrogen (N2). Scanning-electron-microscope (SEM) and X-ray-diffraction (XRD) images were taken to study the original microstructure and mineral content of the shale. To study the macroscale mechanical changes of Wufeng Shale immersed in scCO2 or N2 for 10 hours, triaxial tests with controlled coring angles were conducted. SEM and XRD images were taken after the triaxial tests. In the SEM images, tight bedding planes and undamaged minerals (with sharp edges and smooth surfaces) were found in N2-treated samples both before and after testing, indicating that exposure to N2 did not affect the microstructures. However, the SEM images for the microstructure scCO2-treated samples before and after testing were quite different. The bedding planes were damaged, which left some connected microfractures and corrosion holes, and some mineral types were broken into small particles and left with uneven mineral surfaces. This shows that scCO2 can change rock microstructures and make some minerals (e.g., calcite) fracture more easily. The complex microscale fractures and the decrease in strength for scCO2-treated shale aid the seepage and gathering of gas, enhancing shale-gas recovery. Knowledge of the multiscale physical and chemical changes of shale exposed to scCO2 is not only essential for scCO2 fracturing, but it is also important for scCO2 jets used to break rock and for the geological storage of CO2.
Decreased Electron Transfer between Cr(VI) and AH2DS in the Presence of Goethite
Authors: Tomaszewski Elizabeth J. , Ginder‐Vogel Matthew 
Published: December 2017

9,10‐Anthraquinone‐2,6‐disulfonic acid (AQDS) is commonly used as a model species to examine the influence of quinones on different biogeochemical cycles. The reduced form of this quinone, AH2DS, can donate electrons to the toxic metal species Cr(VI), leading to the precipitation of less soluble Cr(III) phases. Due to the environmental abundance of Fe(III) (oxyhydr)oxides, such as goethite (α‐FeOOH), it is important to study the role of these mineral phases on the electron transfer reaction between AH2DS and Cr(VI). In this study, this electron transfer reaction is examined in the presence and absence of goethite at three different ratios of AH2DS/Cr(VI). Ultraviolet‐visible spectroscopy is used to qualitatively assess the oxidation state of AQDS during reactions with goethite. Iron K‐edge and Cr K‐edge X‐ray absorption spectroscopy are used to examine the role of goethite in electron transfer and identify Cr(III) phases that form. Goethite inhibits the extent of Cr(VI) reduction to Cr(III), most notably at the highest ratio of AH2DS/Cr(VI) investigated. Production of semiquinone radical species may limit electron transfer and decrease the yields of Fe(II) and Cr(III), both in the presence and absence of goethite. Understanding abiotic electron transfer reactions that occur in systems with multiple redox active species is important to determine the contribution of abiotic redox reactions to Fe biogeochemical cycling in natural soils.Core Ideas
Goethite inhibits the reduction of Cr(VI) to Cr(III) in the presence of AH2DS.
Semiquinone radical production probably leads to a decrease in reducing equivalents.
X‐ray absorption spectroscopy shows no FexCrx(OH)3 phases form in Cr(VI) reduction.
Isolation of Mutations Conferring Increased Glyphosate Resistance in Spring Wheat
Authors: Aramrak Attawan , Lawrence Nevin C. , Demacon Victor L. , Carter Arron H. , Kidwell Kimberlee K. , Burke Ian C. , Steber Camille M. 
Published: December 2017

ABSTRACTA mutation breeding approach was used to explore the feasibility of isolating glyphosate‐resistant (GR) wheat (Triticum aestivum L.) lines. Although transgenic GR wheat cultivars were developed, they were never introduced due to lack of consumer acceptance and concern over management of volunteer wheat in rotation. Large‐scale screening experiments recovered ethyl methanesulfonate mutants able to resist 360 to 480 g acid equivalent (ae) ha−1 glyphosate in four spring wheat cultivars, ‘Hollis’, ‘Louise’, ‘Macon’, and ‘Tara2002’, indicating that it is possible to recover resistance in a wide range of genetic backgrounds (glyphosate is typically applied at 840 g ae ha−1 in transgenic crops). Glyphosate rates of 420 to 530 g ae ha−1 were sufficient to kill the susceptible wild‐type parents. Seven GR mutants were characterized: GRH9‐5, GRH9‐8, GRL1, GRL33, GRL65, GRM14, and GRT20. Glyphosate resistance was examined at the whole‐plant level in dose–response experiments. Three mutant lines—GRL33, GRH9‐5, and GRT20—exhibited resistance based on a significant increase in the dose required to retard growth compared with the corresponding susceptible wild type. According to F2 segregation analysis, GRL1, GRL65, and GRT20 segregated as a single dominant gene, whereas GRL33, GRH9‐5, and GRH9‐8 appeared to be either a single semidominant or polygenic trait. Although GRL1 was associated with an amino acid substitution (L239F) in TaEPSPS‐7D1, no nucleotide changes were observed in the coding regions of wheat 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS) gene in GRL33 and GRH9‐8. Results suggest that glyphosate resistance can result from multiple genetic mechanisms in wheat.
A Simple Enrichment Correction Factor for Improving Erosion Estimation by Rare Earth Oxide Tracers
Authors: Zhang X.C. (John) , Liu G. , Zheng F.L. 
Published: December 2017

Core Ideas
Rare‐earth element oxide tracers are preferably bound to silt and clay particles.
Rare‐earth element tracers are conservative during erosion and transport in each size class.
A simple correction factor reduced erosion estimation error to greater than 4.5%.
The correction method does not require rare‐earth element measurement in different classes.
The rare‐earth element technique is capable of producing high‐quality erosion data.
Spatially distributed soil erosion data are needed to better understand soil erosion processes and validate distributed erosion models. Rare‐earth element (REE) oxides have been extensively tested and used to trace soil movement at plot or small watershed scales to generate spatial erosion data. However, a general concern regarding the accuracy of the technique arose due to selective binding of REE to fine soil particles and their preferential transport during soil erosion by water. Our objective was to develop a simple enrichment correction factor to improve the accuracy of the technique without the need for measuring REE for multiple size classes. A coarse Lithic Ustipsamment soil (2% clay, 20% silt), deliberately tagged with eight REE oxides, was packed into eight zones in a physical model of a small watershed to trace erosion from each zone. Three 30‐min rains were simulated at 1, 1.5, and 2 mm min−1, and runoff was collected every 2 min. Sediment was separated into nine size classes, and REE oxides in each class were extracted and analyzed by inductively coupled plasma–mass spectrometry. Both REE and the silt + clay fraction (<0.05 mm) were enriched in the sediment, resulting in a consistent overestimation of soil loss. An enrichment correction factor, based on enrichment of the <0.05‐mm fraction, effectively corrected the overestimation and reduced the event mean estimation errors from 18 to 40% to <4.5%. The correction circumvents the need for measuring REE for multiple size classes, which is costly and time consuming. Moreover, this study found that REE tracers were conservative within each size class during erosion, and this scientifically underpins the use of an enrichment correction factor and erosion tracing by multiple size classes. The correction factor should be further tested with different soils.
Hydro‐sedimentary Dynamics of a Drained Agricultural Headwater Catchment: A Nested Monitoring Approach
Authors: Grangeon T. , Manière L. , Foucher A. , Vandromme R. , Cerdan O. , Evrard O. , Pene-Galland I. , Salvador-Blanes S. 
Published: December 2017

Core Ideas
Discharge and sediment concentrations were measured in a drained catchment.
The impact of tile drainage at the catchment scale was analyzed with a nested approach.
The major part of sediment fluxes occurred during winter floods.
Sediment transfer in the tile drain was episodic although significant.
Soil erosion and sediment transfer are extensive in lowland agricultural catchments. In these environments, high‐frequency datasets of both water discharge and suspended sediment concentrations are often lacking. In particular, the impact of tile drainage networks on sediment fluxes in these catchments is poorly understood. Our research quantified sediment fluxes between 2013 and 2016 at five nested stations including a tile drain outlet across a small (25‐km2) agricultural catchment (located in the Loire River basin, France) representative of lowland cultivated environments of the middle part of this basin. Sediment fluxes varied from 1 to 38 t km−2 yr−1 across the monitored subcatchments. Most of sediment fluxes (79 ± 9%) were measured during flood events (n = 44), mostly occurring in winter (75%) and spring (20%). Seasonality controlled most of the variations of sediment fluxes. Sediment transfers in tile drains occurred episodically. Flows were measured during 11.4% of the monitoring time. A mean time lag of 80 min was recorded between the peak discharge at the drain outlet and the downstream river station. At the event scale, sediment fluxes exported from the tile drain varied between 1.1 × 10−4 and 2.5 t km−2 and remained of the same order of magnitude as those measured at the downstream river station, although the latter were on average 53% lower. Results suggest significant storage of sediment material in the river channel and its export during the most intense flood events. Our research emphasizes the need for continuous monitoring of water and sediment transfers in agricultural catchments equipped with tile drains.
Transport Time Scales in Soil Erosion Modeling
Authors: Lisle I.G. , Sander G.C. , Parlange J.-Y. , Rose C.W. , Hogarth W.L. , Braddock R.D. , Stagnitti F. , Lockington D.A. , Jomaa S. , Cheraghi M. , Barry D.A. 
Published: December 2017

Core Ideas
Erosion timescales inherent in the Hairsine–Rose soil erosion are exposed.
Both fast and slow timescales are isolated and can be estimated a priori.
The maximum sediment settling rate controls the possible range of timescales.
In practice, the full range of erosion timescales are not seen in flume experiments.
Unlike sediment transport in rivers, erosion of agricultural soil must overcome its cohesive strength to move soil particles into suspension. Soil particle size variability also leads to fall velocities covering many orders of magnitude, and hence to different suspended travel distances in overland flow. Consequently, there is a large range of inherent timescales involved in transport of eroded soil. For conditions where there is a constant rainfall rate and detachment is the dominant erosion mechanism, we use the Hairsine–Rose (HR) model to analyze these timescales, to determine their magnitude (bounds) and to provide simple approximations for them. We show that each particle size produces both fast and slow timescales. The fast timescale controls the rapid adjustment away from experimental initial conditions—this happens so quickly that it cannot be measured in practice. The slow timescales control the subsequent transition to steady state and are so large that true steady state is rarely achieved in laboratory experiments. Both the fastest and slowest timescales are governed by the largest particle size class. Physically, these correspond to the rate of vertical movement between suspension and the soil bed and the time to achieve steady state, respectively. For typical distributions of size classes, we also find that there is often a single dominant timescale that governs the growth in the total mass of sediment in the non‐cohesive deposited layer. This finding allows a considerable simplification of the HR model, leading to analytical expressions for the evolution of suspended and deposited layer concentrations.
Penggunaan Media Sosial dengan Pendekatan Model AIDA bagi Usaha Kecil dan Menengah
Authors: Syastra Muhammad Taufik , Adam Steffi 
Published: December 2017

Small Medium Enterprise (SMEs) have a strategic role in the development of a country. Every SME needs to improve its competitive advantage. One way to improve the competitive advantage is to utilize social media in running the business. The research aims to This study aims to implement the use of social media with reference to the AIDA Model for SMEs. The fresearch focuses on social media facebook. SMEs are given training in using social media. Training participants as respondents from this research are 20 SMEs. The data analysis technique used is Miles and Hubermann. Results from this study indicate that the AIDA model can be used as an approach in using social media facebook. A total of 20 SMEs have been trained to use social media facebook based on AIDA model
Penilaian Implementasi e-Government di PUSTEKOM Kemendikbud berbasis metode PEGI
Authors: Rahayu Puji 
Published: December 2017

According to the Survey UN (United Nations) in 2014, e-government and innovation can provide major opportunities to transform the public administration becomes a tool of sustainable development, provide services more transparent and more accountable. Formerly, the development of government services can be done with a variety of channels, either through online services, big data, social media, mobile applications, or cloud computing, have expanded our perception of e-government services. The research aims to assess the level of achievement of e-Government implementation in the Ministry of Education and Culture of the Republic of Indonesia. Assessment is measured by the Indonesian e-Government Rating framework. The data in this research are obtained by qualitative approach and descriptive data analysis. The finding of this research that the implementation of e-Government in Ministry of Education and Culture in the category of "Very Good". Based on such an assessment, given the recommendation: assemblying policies Governance of ICT, aligning the ICT Master Plan by principle of ICT Governance, fulfilling documents related to human Resources of ICT and the application documents, the standardization of domain labeling and e-education, completing information systems/ technogy of management and organizational design, assemblying the development plan of e-education content, and development plans of information system and information technology.
Implementasi Fuzzy ELECTRE Untuk Penilaian Kerusakan Akibat Bencana Alam
Authors: Pinem Agusta Praba Ristadi 
Published: December 2017

Indonesia is prone to geology natural disasters, such as the earthquake and tsunami. The research aims to develop decision support system that can be used for assessment of damage caused by natural disaster after disaster. The method used in this system is method of fuzzy ELECTRE and ECLAC. Fuzzy ELECTRE method used to determine the priority of the affected area, while ECLAC method used to calculate the natural disasters damage. Fuzzy method used in the process of assessing the weight and classification process. Variables used in this research is the sector that were damaged. Integration of fuzzy and ELECTRE methods applied in the prioritization of areas affected by natural disasters. The result of this research is classification of disaster area with rank based on weighting. Output visualized decision-making system in the form of dashboards in the form of mapping the area affected by the disaster. The variable rate of interest was made as a decision maker in the form of mapping that indicates the priority areas most severely affected by natural disasters. The process of calculation, analysis and ranking built in one integrated system. Combination mapping and decision support system produce information to support decision making. Ranking information similar with priority in BNPB documents with 0.96 coefficient Rank Spearman correlation (ρ).
Male Urogenital Disorders and Metabolic Syndrome: Possible Links, Characteristics and Potential Treatment Strategies
Authors: Oztekin Cetin Volkan , Kaya-Sezginer Ecem , Yilmaz-Oral Didem , Gur Serap 
Published: December 2017

Background:
Metabolic syndrome (MetS), as a cluster of metabolic derangements which are major
risk factors for vascular disease is one of the most important threats to public health. Although the epidemiological
and limited amount of basic science and clinical evidence link MetS to several male urogenital disorders, a
holistic approach aiming to define common mechanistic pathways and new possible therapeutic targets are lacking.

Objective:
The current review has focused on providing scientific evidence on the role of MetS and its components
on male urogenital disorders and the definition of new therapeutic targets.

Method:
In this review, current clinical and basic science literature were assessed examining the role of MetS in
etiology and pathogenesis of male urogenital disorders and performed through PubMed from 2000 to May 2017.

Results and Conclusion:
MetS shows an important association with common male urogenital disorders such as
benign prostatic enlargement, lower urinary tract symptoms, erectile dysfunction, infertility and renal disease.
MetS affects male urogenital system mainly through endocrine and vascular mechanisms. Obesity, hypogonadism,
obesity-induced androgen deficiency, hyperinsulinemia and inflammation are the mechanisms commonly
involved and may act as potential targets for MetS-male urogenital system interrelations. Future studies are
needed to evaluate the therapeutic approaches for intervention in MetS-male urogenital disease relations.