bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rootism, Modernity, and the Jew: Antisemitism and the Reactionary Imaginary, 1789–1945
Authors: Landa Ishay 
Published: October 2024

Abstract
The far-right identification of Jews with modernity has been noted by many scholars, yet most analyses have fallen short of offering a properly dialectical account of antisemitism, one that will scrutinise the antinomies at the heart of the antisemitic discourse and trace their relations to the contradictions of modernity itself. In this paper, I will make modernity as movement the focus of the analysis.
Modernity, philosophically underpinned by the Enlightenment, and politically ushered in by the French Revolution of 1789, was seen by its reactionary and fascist opponents both as a time of great upheaval, constant change and social disruption, but also as the setting-up of an era of stasis and degeneration. It was paradoxically decried, sometimes simultaneously, as both helplessly nomadic and incurably sedentary. And in both respects ‘the Jew’ and ‘the Jewish spirit’ were often placed, no matter how spuriously, at the very centre of attacks. Qua ‘wandering’ or ‘eternal’, the Jews were seen as embodying the spirit of restlessness and lack of roots, undermining tradition and fixed national and racial identities; their dynamic role as revolutionaries, conspirators and rabble rousers was ritually denounced.
Jews were also condemned, however, as a major obstacle to movement and expansion, the arch-enemies of imperialism, seeking to establish a realm of universal brotherhood, peace and egalitarianism. By attacking the Jews, reactionaries and fascists thus attempted to settle their scores with a modernity that they feared and loathed in equal measure.
Negotiating the Climate Long-Term Global Goal
Authors: Beaudoin Simon 
Published: October 2024

Abstract
Global goals play a catalyzing role in orienting efforts to address climate change. Yet, the negotiation of the main goal in climate governance is understudied. This article aims to fill this gap by examining the negotiation, adoption, and refinement of the United Nations Framework Convention on Climate Change’s (unfccc) Long-Term Global Goal (ltgg), from the late 1970s to date. I gather insights from semi-structured interviews with climate governance experts, the scientific literature, and official documentation to highlight the developments that shaped the ltgg over time. The study shows that agential, ideational, normative, structural, and contextual factors co-interacted in negotiating, adopting, and refining the ltgg. Drawing lessons from the ltgg experience, the manuscript contributes to knowledge on the politics of global goals, international negotiations, climate governance, and, more broadly, international relations, diplomacy, and global environmental politics.
Development of an automated radial scanning microscopy-based imaging system and its use for measuring resin canal size and frequency in Pinus taeda
Authors: Pokhrel Nawa Raj , Dahlen Joseph , Eberhardt Thomas L. , Gandhi Kamal J.K. 
Published: October 2024

Summary
Resin canals produce and transport oleoresins that are important for tree defenses within the Pinaceae family. Rapid measurement techniques are needed to better understand how resin canal characteristics vary due to genetic and environmental effects. Here we describe a semi-automated microscopy imaging system that was built for quantifying longitudinal resin canals. Tree increment cores from 210 loblolly pine (Pinus taeda L.) trees were prepared into radial strips and the transverse surface of the samples polished with 400 and then 600 grit sandpaper. Each sample was imaged along its entire length (pith to bark) with the images collected from a monochrome camera connected to a Plan Fluorite 4× objective lens. The samples were imaged on the transverse surface via transmitted 850 nm near-infrared light directed at the radial surfaces of the samples. A total of 24 153 images were collected and then processed offline in Python using the Open Computer Vision Library (OpenCV) using a series of algorithms including contrast correction, noise removal, thresholding, contour identification, erosion, and dilation. A total of 24 491 resin canals were identified and their size quantified. The resin canals were assigned into annual rings and positioned within the earlywood or latewood of a ring using cross-correlation whereby a pseudo-density value was derived from the images and matched with density values measured by X-ray densitometry. Of the total resin canals identified, 51.5% were in the earlywood and 48.5% in the latewood, with the majority being detected in the earlywood in the first six years and the latewood in years 7 and above. This study represents the most information collected on the resin canals of loblolly pine. The detailed description of the hardware and image analysis methods should serve as a useful guide to others interested in imaging resin canals as well as other anatomical features.
Natation et perfection : un marqueur de la civilisation arabo-islamique
Authors: Chraïbi Aboubakr , Mezeghrane Samira 
Published: October 2024

Abstract
Swimming (sibāḥa / ʿawm) enjoyed a very positive image in the premodern Arab world and, according to several classical authors, its practice was highly recommended by the caliph ʿUmar b. al-Ḫaṭṭāb. Pioneering work has shown that Greek traditions are at the root of such a phenomenon. It remains to be understood, however, why Arab scholars had recourse especially to the caliph ʿUmar as the most suitable authority to promote Swimming, and why, specifically in the Arab area, the importance of swimming was stressed to such an extent that, combined with knowledge of Arabic writing and archery, it became a means of achieving perfection, disregarding, thus, any constraints, such as religion or kinship.
Semi-Quantitative Assessment of Surgical Navigation Accuracy During Endoscopic Sinus Surgery in a Real-World Environment
Authors: Allen David Z. , Talmadge Jason , Citardi Martin J. 
Published: October 2024

Introduction: Although surgical navigation is commonly used in rhinologic surgery, data on real world performance are sparse because of difficulties in collecting measurements for target registration error (TRE). Despite publications showing submillimeter TRE, surgeons do report TRE of >3 mm. We describe a novel method for assessing TRE during surgery and report findings with this technique. Methods: The TruDi navigation system (Acclarent, Irving, CA) was registered using a contour-based protocol. The surgeon estimated target registration error (e-TRE) at up to 8 points (anatomic regions of interest [ROI]) during endoscopic sinus surgery (ESS). System logs were used to simulate the localization for quantitative assessment of TRE (q-TRE). Results: We performed 98 localizations in 20 patients. The ROI in the sinuses were ethmoid (33 sites), maxillary (28 sites), frontal (17 sites), and sphenoid (22 sites). For localizations, mean qTRE and eTRE were 0.93 and 0.84 mm ( P = .56). Notably, 80% of qTRE and 81% of eTRE were 1 mm or less. Mean qTRE and eTRE were less for attending-performed registrations at the maxillary, frontal and sphenoid. Conclusion: Surgical navigation accuracy, as measured by qTRE and eTRE, approaches 1 mm or better at all sinus sites in a real-world setting for 80% of localizations. The qTRE method provides a unique approach for assessing TRE. Surgeons underestimate TRE (overstate navigation accuracy), but this difference does not seem to be statistically significant. Registration performed by trainees yields higher TRE than registration performed by attendings. These data may be used to guide navigation optimization.
Endonasal Thermal Imaging Before and After Nasal Airway Surgery
Authors: Seresirikachorn Kachorn , Png Lu Hui , Do Timothy Quy-Phong , Kalish Larry , Campbell Raewyn G. , Rimmer Janet , Alvarado Raquel , Raji Nelufer , Choy Christine , Snidvongs Kornkiat , Sacks Raymond , Harvey Richard J. 
Published: October 2024

Objective Nasal airway surgery is often applied when treatment fails to relieve nasal obstruction. However, surgery that improves airflow does not always alleviate the symptoms of nasal obstruction. The perception of nasal breathing is likely more related to changes in mucosal temperature than the mechanical sensation of flow or pressure. This study aims to measure intranasal mucosal temperature pre-and post-surgery using endonasal thermal imaging, exploring its correlation with subjective nasal breathing and objective airflow measurements. Methods A prospective study of adult patients with nasal obstruction managed with nasal airway surgery was performed. Intranasal mucosal temperatures were determined using the thermal endonasal image of the nasal passage produced by the infrared radiometric thermal camera (FILR VS290). A comparison was made between the mean values of mid-expiration (ExT) and mid-inspiration (InT) temperature data (internal nasal valve, nasal cavity, inferior turbinate, and overall airway [mean value]) and visual analog scale (VAS), Nasal Obstruction Symptom Evaluation (NOSE) scale and nasal airway resistance (NAR) before and after surgery. Results Seven patients (35.14 ± 16.45 years, 57.14% female) were included. All NOSE, VAS, and NAR improved after surgery (59.29 ± 10.89 vs 17.14 ± 14.64; P < .001, 64.50 ± 26.79 vs 18.57 ± 19.99; P < .001, 0.82 ± 0.48 vs 0.34 ± 0.11 Pa/cm3/s; P = .002, respectively). ExT, InT, and the difference between ExT and InT of three areas and overall airway were similar between pre-and post-surgery. No statistically significant correlations were found between intranasal mucosal temperature, VAS, NOSE, and NAR at pre-and post-surgery except for the difference between ExT and InT of overall airway and NOSE pre-operative (Pearson r = 0.57; 95% CI 0.06-1.09; P = .03). Conclusion Endonasal thermal imaging can assess the intranasal mucosal temperature of a patient. However, more precise imaging of the nasal passages and data acquisition are required to establish mucosal temperature as an objective measure of nasal obstruction before and after nasal airway surgery in a clinical setting.
Effect of Gestational Diabetes Mellitus on Newborn Hearing: A Systematic Review
Authors: Aggarwal Komal , Ravi Rohit 
Published: October 2024

Objective: Gestational diabetes mellitus (GDM) is associated with several adverse health conditions in newborns such as preterm birth, hyperbilirubinemia, macrosomia, respiratory distress. However, the effect of GDM on the hearing sensitivity of newborns is still unclear. The study aimed to explore the effect of GDM on newborn hearing. The study aimed to explore the effect of GDM on newborn hearing. Method: A systematic search was conducted using PubMed, Scopus, and CHINAL databases. Keywords like “gestational diabetes,” “diabetic pregnancies,” “hearing loss,” “hearing impairment,” and “hearing disorder” were used to form a search string. The Rayyan software was used for screening procedure. The full-length articles were shortlisted, extracted, and appraised. Results: The 7 articles were included in the review. Findings suggest that hearing loss is more prevalent in newborns with GDM pregnancies than in non-GDM pregnancies. In addition, OAE findings were “referred during the first hearing screening of newborns with GDM pregnancies.” The refer rate of the first bilateral hearing screening was higher for newborns with GDM pregnancies. Furthermore, children of diabetic pregnancies were found to be at risk of bilateral hearing loss, particularly sensorineural in nature. Conclusion: The present systematic review suggests an association between GDM and a higher refer rate in hearing screening. A multidisciplinary collaboration between gynecologists, pediatricians, and audiologists can smoothen the early detection of hearing loss in newborns with GDM pregnancies, leading to early intervention and better clinical outcomes to improve the quality of life of affected newborns.
Does industry co-location improve corporate information environment?
Authors: Boone Jeff P , Kang Tae G , Park Sung-Jin 
Published: October 2024

This study examines how the co-location of firms within the same industry enhances their information environments. We hypothesize that benefits arise from two effects: the industry peer effect, involving intra-industry information spillovers, and the geographic peer effect, related to shared local economic conditions with nearby non-industry peers. Our analysis evaluates how these effects, both separately and jointly, impact analysts’ forecast properties and stock price informativeness regarding future earnings. We find that the industry peer effect is negatively related to forecast dispersion and positively related to forecast accuracy, while the geographic peer effect shows no significant correlation. In addition, stock price informativeness about future earnings is positively associated with the industry peer effect but not with the geographic peer effect. We also find that greater proximity to industry or local peers enables analysts to incorporate more private (relative to public) information into their earnings forecasts, thereby enhancing the firm’s information environment. JEL CLASSIFICATION: M41, D80, G10
How I treat sickle cell disease with gene therapy
Authors: Sharma Akshay 
Published: October 2024

Abstract
In 2023, 2 different gene therapies were approved for individuals with severe sickle cell disease (SCD). The small number of patients treated on the pivotal clinical trials that led to these approvals have experienced dramatic short-term reductions in the occurrence of painful vaso-occlusive crises, but the long-term safety and efficacy of these genetic therapies are yet to be ascertained. Several challenges and treatment-related concerns have emerged in regard to administering these therapies in clinical practice. This article discusses the selection and preparation of individuals with SCD who wish to receive autologous gene therapy, as well as the salient features of the care needed to support them through a long and arduous treatment process. I specifically focus on postinfusion care, as it relates to immune monitoring and infection prevention. Compared with allogeneic hematopoietic cell transplantation, delivering autologous gene therapy to an individual with SCD has distinct nuances that require awareness and special interventions. Using clinical vignettes derived from real-life patients, I provide perspectives on the complex decision-making process for gene therapy for SCD based on currently available data and make recommendations for evaluating and supporting these patients.
How I treat older patients with relapsed/refractory diffuse large B-cell lymphoma
Authors: Wallace Danielle S. , Loh Kah Poh , Casulo Carla 
Published: October 2024

Abstract
Diffuse large B-cell lymphoma (DLBCL) is an aggressive, yet curable, malignancy, but older patients are at higher risk of relapsed disease because they may not be eligible for full-intensity frontline chemoimmunotherapy or have comorbidities that limit standard treatments. Recent years have brought more treatment options than ever for this patient population, but it remains challenging to determine which can be safely and effectively offered to older patients. Formal determinations of fitness including geriatric assessments remain critical, but there is less guidance on how to best use this tool in the relapsed setting. Chimeric antigen receptor T-cell therapy is accessible to older patients, provided they can be supported through the intensive road to this treatment. If relapse occurs despite this or alternative therapies are preferred, many novel therapeutic options and combinations exist with some potential modifications for older adults, such as bispecific antibodies, tafasitamab and lenalidomide, polatuzumab-containing regimens, or loncastuximab tesirine. This article provides a summary of our approach to the management of this diverse population of older patients with relapsed or refractory DLBCL.
Ex vivo venetoclax sensitivity predicts clinical response in acute myeloid leukemia in the prospective VenEx trial
Authors: Kytölä Sari , Vänttinen Ida , Ruokoranta Tanja , Partanen Anu , Holopainen Annasofia , Saad Joseph , Kuusisto Milla E. L. , Koskela Sirpa , Räty Riikka , Itälä-Remes Maija , Västrik Imre , Suvela Minna , Parsons Alun , Porkka Kimmo , Wennerberg Krister , Heckman Caroline A. , Jalkanen Tero , Huttunen Teppo , Ettala Pia , Rimpiläinen Johanna , Siitonen Timo , Pyörälä Marja , Kuusanmäki Heikki , Kontro Mika 
Published: October 2024

Abstract
The B-cell lymphoma 2 inhibitor venetoclax has shown promise for treating acute myeloid leukemia (AML). However, identifying patients likely to respond remains a challenge, especially for those with relapsed/refractory (R/R) disease. We evaluated the utility of ex vivo venetoclax sensitivity testing to predict treatment responses to venetoclax-azacitidine in a prospective, multicenter, phase 2 trial. The trial recruited 104 participants with previously untreated (n = 48), R/R (n = 39), or previously treated secondary AML (sAML) (n = 17). The primary end point was complete remission or complete remission with incomplete hematologic recovery (CR/CRi) rate in ex vivo sensitive trial participants during the first 3 therapy cycles. The key secondary end points included the correlations between ex vivo drug sensitivity, responses, and survival. Venetoclax sensitivity was successfully assessed in 102 of 104 participants, with results available within a median of 3 days from sampling. In previously untreated AML, ex vivo sensitivity corresponded to an 85% (34/40) CR/CRi rate, with a median overall survival (OS) of 28.7 months, compared with 5.5 months for ex vivo resistant patients (P = .002). For R/R/sAML, ex vivo sensitivity resulted in a 62% CR/CRi rate (21/34) and median OS of 9.7 vs 3.3 months for ex vivo resistant patients (P &lt; .001). In univariate and multivariate analysis, ex vivo venetoclax sensitivity was the strongest predictor for a favorable treatment response and survival. This trial demonstrates the feasibility of integrating ex vivo drug testing into clinical practice to identify patients with AML, particularly in the R/R setting, who benefit from venetoclax. This trial was registered at www.clinicaltrials.gov as #NCT04267081.
Time to STEP UP: methods and findings from the development of guidance to help researchers design inclusive clinical trials
Authors: Biggs K. , Hullock K. , Dix C. , Lane JA. , Green H. , Treweek S. , Shiely F. , Shepherd V. , Willis A. , Isaacs T. , Cooper C. 
Published: October 2024

Abstract
Background
It is important to design clinical trials to include all those who may benefit from the intervention being tested. Several frameworks have been developed to help researchers think about the barriers to inclusion of particular under-served groups when designing a trial, but there is a lack of practical guidance on how to implement these frameworks. This paper describes the ACCESS project, the findings from each phase of the project and the guidance we developed (STEP UP) on how to design more inclusive trials.

Methods
Development of the STEP UP guidance had five phases: (1) Scoping literature review, (2) ‘roundtable’ discussion meetings, (3) redesign of trials, (4) interviews and (5) guidance document development, with input from public contributors and the ACCESS team.

Results
Over 40 experts contributed to the ACCESS project—patients and the public, clinicians, NHS research staff, trialists and other academics. The scoping review identified several strategies being used to improve inclusion, mostly around recruitment settings, but there was little evaluation of these strategies. The ‘roundtable’ discussions identified additional strategies being used across the UK and Ireland to improve inclusion, which were grouped into: Communication, Community engagement, Recruitment sites, Patient information, Flexibility, Recruitment settings, Consent process, Monitoring, Training for researchers and Incentives. These strategies were used to redesign three existing trials by applying one of the three INCLUDE frameworks (ethnicity, socioeconomic disadvantage, impaired capacity to consent) to one trial each, to produce the key recommendations for the guidance. Issues around implementation were explored in stakeholder interviews and key facilitators were identified: funders requesting information on inclusion, having the time and funding to implement strategies, dedicated staff, flexibility in trial protocols, and considering inclusion of under-served groups at the design stages. The STEP UP guidance is freely available at http://step-up-clinical-trials.co.uk.

Conclusion
Researchers should consider inclusivity to shape initial trial design decisions. Trial teams and funders need to ensure that trials are given both the resources and time needed to implement the STEP UP guidance and increase the opportunities to recruit a diverse population.
Three-outcome designs for external pilot trials with progression criteria
Authors: Wilson Duncan T. , Hudson Eleanor , Brown Sarah 
Published: October 2024

Abstract
Background
Whether or not to progress from a pilot study to a definitive trial is often guided by pre-specified quantitative progression criteria with three possible outcomes. Although the choice of these progression criteria will help to determine the statistical properties of the pilot trial, there is a lack of research examining how they, or the pilot sample size, should be determined.

Methods
We review three-outcome trial designs originally proposed in the phase II oncology setting and extend these to the case of external pilots, proposing a unified framework based on univariate hypothesis tests and the control of frequentist error rates. We apply this framework to an example and compare against a simple two-outcome alternative.

Results
We find that three-outcome designs can be used in the pilot setting, although they are not generally more efficient than simpler two-outcome alternatives. We show that three-outcome designs can help allow for other sources of information or other stakeholders to feed into progression decisions in the event of a borderline result, but this will come at the cost of a larger pilot sample size than the two-outcome case. We also show that three-outcome designs can be used to allow adjustments to be made to the intervention or trial design before commencing the definitive trial, providing the effect of the adjustment can be accurately predicted at the pilot design stage. An package, , is provided to optimise progression criteria and pilot sample size.

Conclusions
The proposed three-outcome framework provides a way to optimise pilot trial progression criteria and sample size in a way that leads to desired operating characteristics. It can be applied whether or not an adjustment following the pilot trial is anticipated, but will generally lead to larger sample size requirements than simpler two-outcome alternatives.