bluuebunny/crossref_metadata_2025_split huggingface dataset:
Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways
Authors: Chen Xiaoling , Luo Yanliu , Huang Zhiqing , Jia Gang , Liu Guangmang , Zhao Hua 
Published: March 2017

AbstractAkirin2, a novel nuclear factor, plays an important role in myogenesis. To investigate the role of Akirin2 in proliferation and differentiation of porcine skeletal muscle satellite cells, Akirin2 overexpression and Akirin2 silence technologies were employed. Our results showed that overexpression of Akirin2 markedly enhanced the proliferation and differentiation of porcine skeletal muscle satellite cells, whereas silencing of Akirin2 got the opposite results. Furthermore, our results showed that Akirin2 affected proliferation and differentiation of porcine skeletal muscle satellite cells through extracellular-signal regulated kinase-1/2 (ERK1/2) and NFATc1 signaling pathways. These results indicate that Akirin2 can effectively promote skeletal muscle satellite cells proliferation and differentiation, acting through ERK1/2- and NFATc1-dependent mechanisms.
Imaging of Cholangiocarcinoma
Authors: Sahani Dushyant , Arellano Ronald 
Published: March 2017

AbstractCross-section imaging plays an increasingly important role in the evaluation and diagnosis of cholangiocarcinoma (CC). CCs can have varied radiological appearances, depending on their location, morphology, as well as their histological characteristics. An awareness of the varied imaging manifestations of CC and its accurate diagnosis are necessary to direct appropriate management. Recent advances in imaging techniques, histological assessment, molecular imaging, surgical techniques, and radiation therapy have all revitalized interest in the diagnosis and management of CCs.
A Comparative Study between Universal Eclectic Septoplasty Technique and Cottle
Authors: Amaral Neto Odim , Mizoguchi Flavio , Freitas Renato , Maniglia João , Maniglia Fábio , Maniglia Ricardo 
Published: March 2017

Introduction Since the last century surgical correction of nasal septum deviation has been improved. The Universal Eclectic Technique was recently reported and there are still few studies dedicated to address this surgical approach.
Objective The objective of this study is to compare the results of septal deviation correction achieved using the Universal Eclectic Technique (UET) with those obtained through Cottle's Technique.
Methods This is a prospective study with two consecutive case series totaling 90 patients (40 women and 50 men), aged between 18 and 55 years. We divided patients into two groups according to the surgical approach. Fifty-three patients underwent septoplasty through Universal Eclectic Technique (UET) and thirty-seven patients were submitted to classical Cottle's septoplasty technique. All patients have answered the Nasal Obstruction Symptom Evaluation Scale (NOSE) questionnaire to assess pre and postoperative nasal obstruction.
Results Statistical analysis showed a significantly shorter operating time for the UET group. Nasal edema assessment performed seven days after the surgery showed a prevalence of mild edema in UET group and moderate edema in Cottle's technique group. In regard to complication rates, UET presented a single case of septal hematoma while in Cottle's technique group we observed: 02 cases of severe edemas, 01 case of incapacitating headache, and 01 complaint of nasal pain.
Conclusion The Universal Eclectic Technique (UET) has proven to be a safe and effective surgical technique with faster symptomatic improvement, low complication rates, and reduced surgical time when compared with classical Cottle's technique.
Experimental comparison of two quantum computing architectures
Authors: Linke Norbert M. , Maslov Dmitri , Roetteler Martin , Debnath Shantanu , Figgatt Caroline , Landsman Kevin A. , Wright Kenneth , Monroe Christopher 
Published: March 2017

Significance
Quantum computers are an emerging technology promising to be vastly more powerful at solving certain problems than any conventional computer. These devices are now moving out of the laboratory and becoming generally programmable. This allows identical quantum tasks or algorithms to be implemented on radically different technologies to inform further development and scaling. We run a series of algorithms on the two leading platforms: trapped atomic ions and superconducting circuits. Whereas the superconducting system offers faster gate clock speeds and a solid-state platform, the ion-trap system features superior qubits and reconfigurable connections. The performance of these systems is seen to reflect the topology of connections in the base hardware, supporting the idea that quantum computer applications and hardware should be codesigned.
Comprehensive and quantitative mapping of RNA–protein interactions across a transcribed eukaryotic genome
Authors: She Richard , Chakravarty Anupam K. , Layton Curtis J. , Chircus Lauren M. , Andreasson Johan O. L. , Damaraju Nandita , McMahon Peter L. , Buenrostro Jason D. , Jarosz Daniel F. , Greenleaf William J. 
Published: March 2017

Significance
High-throughput sequencing has transformed modern biology, but its repertoire is currently confined to reading DNA molecules. Here, we report hardware and software adaptations that allow the very methods that enabled the genomic sequencing revolution to be applied to fluorescence-based biochemical assays, on a massive scale. We demonstrate the unique value of this approach by finding previously unknown features of an ancient developmental regulator, Vts1 (Smaug in metazoans), despite its extensive study with previously available techniques. Our work couples transcriptome-wide measurements of binding affinity, sequence, and structural determinants of binding, and phenotypic outcomes to provide a comprehensive portrait of Vts1 function. Our technology is easily extensible to other RNA-binding proteins involved in disease and development, and facilitates diverse applications in systems biochemistry.
Ab initio solution of macromolecular crystal structures without direct methods
Authors: McCoy Airlie J. , Oeffner Robert D. , Wrobel Antoni G. , Ojala Juha R. M. , Tryggvason Karl , Lohkamp Bernhard , Read Randy J. 
Published: March 2017

Significance
It is now possible to make an accurate prediction of whether or not a molecular replacement solution of a macromolecular crystal structure will succeed, given the quality of the model, its size, and the resolution of the diffraction data. This understanding allows the development of powerful structure-solution strategies, and leads to the unexpected finding that, with data to sufficiently high resolution, fragments as small as single atoms can be placed as the basis for ab initio structure solutions.
Bull Trout Movements Match the Life History of Sockeye Salmon: Consumers Can Exploit Seasonally Distinct Resource Pulses
Authors: Furey N. B. , Hinch S. G. 
Published: March 2017

AbstractResource pulses provide consumers with opportunities to feed at high rates. The spawning and die‐off of semelparous Pacific salmon provide consumers with feeding opportunities that contribute substantially to annual energy budgets. The life history of Pacific salmon also includes the downstream migration of smolts, which could provide similar opportunities for consumers to exploit. We tracked seasonal movements of adult Bull Trout Salvelinus confluentus in and out of the Chilko Lake–River outlet in interior British Columbia, which is characterized by a large Sockeye Salmon Oncorhynchus nerka population. Use of the outlet, lake, and river habitats were compared with the timing of out‐migrations of Sockeye Salmon smolt and the spawning events of Sockeye Salmon, Chinook Salmon O. tshawytscha, and Coho Salmon O. kisutch. Bull Trout activity and residency in the outlet increased during the spring Sockeye Salmon smolt out‐migration, and 40% of Bull Trout were found to return to the outlet in successive years. During Sockeye Salmon spawning, Bull Trout residency was increased in the river where most Sockeye Salmon spawning occurs. Therefore, Bull Trout may exploit both life history events, although direct consumption of eggs was not observed. Spawning by Chinook Salmon and Coho Salmon in the river did not appear to attract Bull Trout; Bull Trout residency increased in the lake (where spawning does not occur) during these times. Bull Trout residency in the lake also increased when outlet water temperatures were >16°C, and thus the lake may provide thermal refuge when river temperatures are above optima for this coldwater char. This research demonstrates that movements of aquatic consumers can depend upon smolt out‐migrations, and such movements can allow exploitation of multiple pulses that are seasonally distinct. These results also highlight the ecological significance of Pacific salmon for consumers in freshwater systems.Received August 18, 2016; accepted January 11, 2017 Published online March 21, 2017
Spanish version of the Objectified Body Consciousness Scale (OBCS): results from two samples of female university students / Versión española de la Objectified Body Consciousness Scale (OBCS): resultados correspondientes a dos muestras de estudiantes universitarias
Authors: Moya-Garófano Alba , Megías Jesús L. , Rodríguez-Bailón Rosa , Moya Miguel 
Published: March 2017

Self-objectification happens when people internalize a view of themselves as an object or collection of body parts. Two studies were conducted to validate the Spanish version of the Objectified Body Consciousness Scale (OBCS). This scale assesses self-objectification through three components: body surveillance, body shame and appearance control beliefs in women. In Study 1 and Study 2, 218 and 201 female undergraduate students, respectively, responded to the Spanish version of this scale and other related measures. In Study 2, they also reported on their emotions after being exposed to an objectifying scenario. The three subscales of the Spanish version of the OBCS showed acceptable indices of internal consistency (ranging between α = .68 to .84), and the confirmatory factor analysis showed a three-factor solution to be the most appropriate. Adequate convergent validity was found with respect to the Self-Objectification Questionnaire (SOQ) and other variables such as self-esteem, other-directedness, hostile sexism and enjoyment of sexualization. These findings suggest that the Spanish version of the OBCS is a satisfactory measure of college women’s self-objectification.
3D technology of Sony Bloggie has no advantage in decision‐making of tennis serve direction: A randomized placebo‐controlled study
Authors: Liu Sicong , Ritchie Jason , Sáenz‐Moncaleano Camilo , Ward Savanna K. , Paulsen Cody , Klein Tyler , Gutierrez Oscar , Tenenbaum Gershon 
Published: March 2017

AbstractThis study aimed at exploring whether 3D technology enhances tennis decision‐making under the conceptual framework of human performance model. A 3 (skill‐level: varsity, club, recreational) × 3 (experimental condition: placebo, weak 3D [W3D], strong 3D [S3D]) between‐participant design was used. Allocated to experimental conditions by a skill‐level stratified randomization, 105 tennis players judged tennis serve direction from video scenarios and rated their perceptions of enjoyment, flow, and presence during task performance. Results showed that varsity players made more accurate decisions than less skilled ones. Additionally, applying 3D technology to typical video displays reduced tennis players’ decision‐making accuracy, although wearing the 3D glasses led to a placebo effect that shortened the decision‐making reaction time. The unexpected negative effect of 3D technology on decision‐making was possibly due to participants being more familiar to W3D than to S3D, and relatedly, a suboptimal task‐technology match. Future directions for advancing this area of research are offered.Highlights
3D technology augments binocular depth cues to tradition video displays, and thus results in the attainment of more authentic visual representation. This process enhances task fidelity in researching perceptual‐cognitive skills in sports.
The paper clarified both conceptual and methodological difficulties in testing 3D technology in sports settings. Namely, the nomenclature of video footage (with/without 3D technology) and the possible placebo effect (arising from wearing glasses of 3D technology) merit researchers' attention.
Participants varying in level of domain‐specific expertise were randomized into viewing conditions using a placebo‐controlled design. Measurement consisted of both participants' subjective experience (i.e., presence, flow, and enjoyment) and objective performance (i.e., accuracy and reaction time) in a decision‐making task.
Findings revealed that wearing glasses of 3D technology resulted in a placebo effect that shortened participants' reaction times in decision‐making. Moreover, participants' decision‐making accuracy decreased when viewing video scenarios using 3D technology. The findings generated meaningful implications regarding applying 3D technology to sports research.
Invited Commentary: Selection Bias Without Colliders
Authors: Hernán Miguel A. 
Published: March 2017

Abstract
In causal analyses, conditioning on a collider generally results in selection bias. Conditioning on a prognostic factor that is independent of the exposure—and therefore is not a collider—can also result in selection bias when 1) the exposure has a non-null effect on the outcome and 2) the association between the noncollider and the outcome is heterogenous across levels of the exposure. This result was empirically demonstrated by Greenland in 1977 (Am J Epidemiol. 1977;106(3):184–187).
biMM: efficient estimation of genetic variances and covariances for cohorts with high-dimensional phenotype measurements
Authors: Pirinen Matti , Benner Christian , Marttinen Pekka , Järvelin Marjo-Riitta , Rivas Manuel A , Ripatti Samuli 
Published: March 2017

Abstract

Summary
Genetic research utilizes a decomposition of trait variances and covariances into genetic and environmental parts. Our software package biMM is a computationally efficient implementation of a bivariate linear mixed model for settings where hundreds of traits have been measured on partially overlapping sets of individuals.

Availability and Implementation
Implementation in R freely available at www.iki.fi/mpirinen.

Supplementary information
Supplementary data are available at Bioinformatics online.
The bio-economic effects of artificial reefs: mixed evidence from Shandong, China
Authors: Sun Peng , Liu Xiaozi , Tang Yanli , Cheng Wenzhi , Sun Runlong , Wang Xinxin , Wan Rong , Heino Mikko 
Published: March 2017

Abstract
Artificial reefs are used to protect coastal habitats and rebuild fisheries. This engineering approach to fisheries management has gained popularity in many coastal areas, including China. In Shandong province alone, over USD 50 million were invested in artificial reefs during 2005–2013. Have artificial reefs achieved their biological and economic objectives? We compared reef and control sites in terms of catch and value per unit effort and average body length across species, based on surveys carried out during 2012–2013. We found that in aggregate, with all fish and invertebrates combined, artificial reefs did not improve the overall catches or revenues. Instead, seasonal fluctuations were prominent. However, when we allow for species-specific differences and focus on the common fish species, we find that an artificial reef can increase the catch and value per unit effort on average by approximately 40% compared to the control sites. The difference between these contrasting results occurs because some of the dominant species that comprise the bulk of the catches did not benefit from the reef, while many of the less dominant ones did so. This underlines the importance of being specific about what is meant by “benefiting fisheries” when evaluating artificial reefs, as well as when the objectives of reef projects are formulated in the first place. The positive effects of artificial reefs can be caused by the reefs themselves and by their influence on fishing patterns. Our study was not designed to separate these effects but we suggest that in Shandong, restrictions on fishing access may have been as important as the presence of the reef itself.
Observation of Neointimal Coverage Around the Aneurysm Neck After Stent-Assisted Coil Embolization by Optical Frequency Domain Imaging: Technical Case Report
Authors: Yako Rie , Matsumoto Hiroyuki , Masuo Osamu , Nakao Naoyuki 
Published: March 2017

Abstract

BACKGROUND AND IMPORTANCE: Stent-assisted coil embolization has been established as a treatment option for wide-necked or complex aneurysms. However, concerns have been raised about the incidence of thromboembolic complications, which is higher for coil embolization without stent assistance. Long-term antiplatelet therapy is necessary to prevent acute or delayed ischemic events potentially associated with incomplete stent apposition after treatment with stent-assisted coil embolization. Optical frequency domain imaging (OFDI) provides excellent-resolution images of intraluminal structures, allowing evaluation of the outcomes of stent-assisted procedures in terms of stent apposition and neointimal coverage. We here describe the novel use of OFDI for the observation of intravascular tissue formation after stent-assisted coil embolization.

CLINICAL PRESENTATION: Two patients were treated with stent-assisted coil embolization for unruptured vertebral artery aneurysm. At the 1- or 2-yr follow-up visit, routine angiography followed by OFDI were performed to evaluate neointimal coverage of the stent strut and stent apposition to the vascular wall. OFDI enabled clear visualization of the vessel wall structures and demonstrated complete coverage of the stent struts as well as full stent wall apposition in 1 patient and incomplete coverage near the aneurism neck as well as mallaposition of some struts in the other patient.

CONCLUSION: OFDI represents a feasible modality for the evaluation of intracranial vasculature and the outcomes of stent-assisted coil embolization in terms of intimal healing of aneurysms, stent-vessel interactions, and neointimal coverage of the stent. Such information is helpful in determining the duration of antiplatelet therapy after stent-assisted coil embolization.
Two twin binaries with nearly identical components: KIC 4826439 and KIC 6045264
Authors: Zhang Jia , Qian Sheng-Bang , Wang Shu-Min , Wu Yue , Jiang Lin-Qiao 
Published: March 2017

Abstract
Two twin binaries, KIC 4826439 and KIC 6045264, with very similar component stars were found photometrically based on Kepler eclipsing binary light curves. The absolute parameters of the massive components are 1.156(0.03) M⊙, 1.881(0.02) R⊙, 6065 K for KIC 4826439, and 0.874(0.3) M⊙, 1.206(0.02) R⊙, 6169(30) K for KIC 6045264. The differences between the components are less than two percent for all the parameters. A very low proportion of twin binaries (2/1592 ≈ 0.13%) was found, which does not support the previous findings of excesses of twins on binary mass ratio distribution, but supports a deficiently low proportion of twins. A new method is used to work out the absolute parameters of the two twins without the radial velocities. This method requires the solution of the light curves, the spectra, and the evolutionary isochrones covering the complete stellar parameter space, simultaneously. We also studied their evolution tracks: KIC 4826439 will experience an unstable mass transfer stage followed by an unclear ending, and KIC 6045264 will become a single star via an over-contact phase. It seems highly unlikely that the two twin binaries will produce twin degenerate binaries, although they have quite similar components.
The Economic and Clinical Impact of Sustained Use of a Progressive Mobility Program in a Neuro-ICU*
Authors: Hester Jeannette M. , Guin Peggy R. , Danek Gale D. , Thomas Jaime R. , Titsworth William L. , Reed Richard K. , Vasilopoulos Terrie , Fahy Brenda G. 
Published: March 2017

Objective:
To investigate a progressive mobility program in a neurocritical care population with the hypothesis that the benefits and outcomes of the program (e.g., decreased length of stay) would have a significant positive economic impact.

Design:
Retrospective analysis of economic and clinical outcome data before, immediately following, and 2 years after implementation of the Progressive Upright Mobility Protocol Plus program (UF Health Shands Hospital, Gainesville, FL) involving a series of planned movements in a sequential manner with an additional six levels of rehabilitation in the neuro-ICU at UF Health Shands Hospital.

Setting:
Thirty-bed neuro-ICU in an academic medical center.

Patients:
Adult neurologic and neurosurgical patients: 1,118 patients in the pre period, 731 patients in the post period, and 796 patients in the sustained period.

Interventions:
Implementation of Progressive Upright Mobility Protocol Plus.

Measurements and Main Results:
ICU length of stay decreased from 6.5 to 5.8 days in the immediate post period and 5.9 days in the sustained period (F
(2,2641) = 3.1; p = 0.045). Hospital length of stay was reduced from 11.3 ± 14.1 days to 8.6 ± 8.8 post days and 8.8 ± 9.3 days sustained (F
(2,2641) = 13.0; p < 0.001). The impact of the study intervention on ICU length of stay (p = 0.031) and hospital length of stay (p < 0.001) remained after adjustment for age, sex, diagnoses, sedation, and ventilation. Hospital-acquired infections were reduced by 50%. Average total cost per patient after adjusting for inflation was significantly reduced by 16% (post period) and 11% (sustained period) when compared with preintervention (F
(2,2641) = 3.1; p = 0.045). Overall, these differences translated to an approximately $12.0 million reduction in direct costs from February 2011 through the end of 2013.

Conclusions:
An ongoing progressive mobility program in the neurocritical care population has clinical and financial benefits associated with its implementation and should be considered.