bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gifted and Denied
Authors: Olague Diana Ortegon 
Published: July 2017

My third-grade teacher reads a poem. I smile, delighted to spend the afternoon immersed in literature until the teacher comes to an unfamiliar word. What is that word? I scan my classmates. They appear content and seem to understand the lesson. Why don't I? I slide down into my desk as the others excitedly wave their arms in the air hoping to participate in an animated discussion of the story. Why do I always feel so stupid and locked out of the secrets words possess? I am an Hispanic. I somehow extended the limited vocabulary I controlled as a child to succeed in school and college. Of course, a high aptitude and strong perseverance helped me emerge. However, my lack of useful terminology embarrassed me, and I worked twice as hard to compensate. I wanted to bridge the vocabulary gap that interfered with my opportunities to flourish, but escaping this handicap proved difficult. My brain stored information in two languages. Retrieving accurate terminology took longer for me. Some words I knew only in Spanish; some words I never experienced at all. No one in elementary school believed I was smart. Teachers only saw the deficiencies. No one gave me a chance to blossom or to share my own unique and enhanced qualities. Yet, I know now that I was smart, and all my A's in college philosophy and math verified this. Still, I was locked out of the secrets the world held.
Rickettsial Infections around the World, Part 1: Pathophysiology and the Spotted Fever Group
Authors: Wu Jashin J. , Huang David B. , Pang Katie R. , Tyring Stephen K. 
Published: July 2017

Background: The rickettsial diseases are an important group of infectious agents that have dermatological manifestations. These diseases are important to consider in endemic areas, but in certain suspicious cases, possible acts of bioterrorism should warrant prompt notification of the appropriate authorities. Objective: In this two part review article, we review these diverse diseases by examining established and up-to-date information about the pathophysiology, epidemiology, clinical manifestations, and treatment of the ricksettsiae. Methods: Using PubMed to search for relevant articles, we browsed over 500 articles to compose a clinically based review article. Results: Part one focuses on pathophysiology of the rickettsial diseases and the clinical aspects of the spotted fever group. Conclusions: At the completion of part one of this learning activity, participants should be able to discuss all of the clinical manifestations and treatments of the sported fever group. Participants should also be familiar with the pathophysiology of the rickettsial diseases.
Combination Oral Prednisone and Intravenous Immunoglobulin in the Treatment of Scleromyxedema
Authors: Majeski Candace , Taher Muba , Grewal Parbeer , Dytoc Marlene , Lauzon Gilles 
Published: July 2017

Background: Scleromyxedema is a clinical variant of the rare disease papular mucinosis that has both cutaneous and systemic manifestations. Treatment options are numerous and tend to be associated with serious potential side effects and frequent relapse. Objective: We report a case of scleromyxedema treated with low-dose oral prednisone and intravenous immunoglobulin (IVIg). This is followed by a review of the literature. Conclusion: IVIg is being used for a growing number of inflammatory and immune disorders. It is being increasingly reported as a successful treatment for scleromyxedema. Although our patient succumbed to the disease, combination therapy with prednisone and IVIg provided temporary symptomatic, laboratory, and clinical improvement of the condition. Optimization of this therapeutic strategy is thus indicated for the management of scleromyxedema.
Prospective Pilot Study Comparing the Need for Adaptive Radiotherapy in Unresected Bulky Disease and in Postoperative Patients With Head and Neck Cancer
Authors: Mahmoud Omar , Reis Isildinha M. , Samuels Michael M. , Elsayyad Nagy , Bossart Elizabeth , Both Joseph , ELGhoneimy Ehsan , Moustafa Magda , AbdAllah Mohamed , Takita Cristiane 
Published: July 2017

Background: Adaptive radiotherapy is being used in few institutions in patients with head and neck cancer having bulky disease using periodic computed tomography imaging accounting for volumetric changes in tumor volume and/or weight loss. Limited data are available on ART in the postoperative setting. We aim to identify parameters that would predict the need for ART in patients with head and neck cancer and whether ART should be applied in postoperative setting. Materials and Methods: Twenty patients with stage III–IV head and neck cancer were prospectively accrued. A computed tomography simulation was done prior to treatment and repeated at weeks 3 and 6 of concurrent intensity-modulated radiotherapy and chemotherapy. The final plan was coregistered with the subsequent computed tomography images, and dosimetric/volumetric changes at weeks 1 (baseline), 3, and 6 were quantified in high-risk clinical target volumes, low-risk clinical target volumes , right parotid , left parotid , and spinal cord . An event to trigger ART was defined as spinal cord maximum dose >45 Gy, parotid mean dose >26 Gy, and clinical target volume coverage <95%. Results: Comparing the 2 groups, the proportion of patients with at least 1 event triggering ART was higher in bulky disease than in postoperative group: 72.7% versus 18.2% ( P = .03) overall; 54.6% versus 1.8% ( P = .064) at week 3; and 63.6% versus 18.2% ( P = .081) at week 6. In the bulky disease group, 8 of 11 patients had events at week 3 and/or 6 as follows: overdose in spinal cord (n = 2), right parotid (n = 3), left parotid (n = 5), coverage < 95% seen in low-risk clinical target volumes (n = 3), and high-risk clinical target volumes (n = 5). In the postoperative group, 2 of 11 patients had events: spinal cord (n = 1) and low-risk clinical target volume (n = 1). Conclusion: Our study confirmed the need for ART in patients with head and neck cancer having bulky disease due to target under dosing and/or spinal cord/parotids overdosing in weeks 3 and 6. In contrast, the benefit of ART in postoperative patients is less clear.
Adapting DRGs: The British, Canadian and Australian Experiences
Authors: Pilla John , Hindle Don 
Published: July 2017

The DRG classification was developed in the United States, and has been widely used there for analytical and resource allocation purposes. Its utility has been recognised in other countries. Some have adopted US versions without change, and others have chosen to develop their own adaptations. This paper discusses the processes and outcomes of adaptation in Canada, Britain and Australia. An attempt is made to generalise the trends. It is concluded that there is a high degree of similarity of intent, although different solutions have been adopted in some cases. Where major differences remain, they are mostly a consequence of the lack of resources to pursue all opportunities for refinement at the same time. All three countries have correctly focused on involvement of their own clinician groups. However, they have tended to restrict their view to US experiences when looking overseas. It is argued that greater attention should be paid to sharing their ideas with countries with which they have a greater degree of similarity.
A New Continuous Quality Improvement Model for the Coding Process
Authors: Callen Joanne , Meehan Jodee , Tomornsak Saranuj 
Published: July 2017

The following paper describes the development and evaluation of a Continuous Quality Improvement Model (CQIM) applied to the coding process of a public metropolitan teaching hospital. The evaluation was carried out by measuring changes to the accuracy, timeliness and quantity of the outputs of the coding process before and after the CQIM was implemented. For all three indicators of quality and productivity, improvements were observed after the CQIM was implemented. Continuous Quality Improvement methods are one strategy which health information managers can use to improve the quality of the coding process to support the provision of accurate coded data in a timely manner.
Outcomes of Primary Reverse Shoulder Arthroplasty for Dislocation Arthropathy
Authors: Chalmers Brian P , Wagner Eric R , Houdek Matthew T , Sperling John W , Cofield Robert H , Sanchez-Sotelo Joaquin 
Published: July 2017

Background Proper soft tissue balance is paramount to maintaining stability and a functional arc of motion in shoulder arthroplasty but is impaired in patients with prior glenohumeral (GH) dislocations. The purpose of this study was to determine the clinical outcomes, revisions, and complications of reverse shoulder arthroplasty (RSA) in patients with a history of glenohumeral dislocation. Methods Twenty-four patients with a history of GH dislocations that developed arthropathy underwent primary RSA from 2007 to 2013 were retrospectively reviewed. Mean follow-up was 3.3 years (2–7 years). Mean age was 70 years. Eight patients (33%) and 7 patients (29%) had complete or partial subscapularis deficiency, respectively. Results Twenty-two patients (92%) had little to no pain at final follow-up. Mean shoulder elevation improved from 48° to 120° ( P < .001) and mean external rotation increased from 13.2° to 48° ( P < .001). There were trends toward less complete pain relief and poorer motion in those with complete subscapularis deficiency. None of the patients experienced a postoperative dislocation or evidence of glenoid loosening at final radiographic follow-up, but 1 patient (4.2%) underwent early revision to a hemiarthroplasty for glenoid loosening. Conclusion RSA provides patients with prior glenohumeral dislocations a stable, pain-free arc of motion. Postoperative instability was not identified as a major failure mode at short-term follow-up. Complete subscapularis deficiency is a risk factor for poorer clinical outcome.
A novel function for the IκB inhibitor Cactus in promoting Dorsal nuclear localization and activity in the Drosophila embryo
Authors: Cardoso Maira Arruda , Fontenele Marcio , Lim Bomyi , Bisch Paulo Mascarello , Shvartsman Stanislav Y. , Araujo Helena Marcolla 
Published: July 2017

ABSTRACT
The evolutionarily conserved Toll signaling pathway controls innate immunity across phyla and embryonic patterning in insects. In the Drosophila embryo, Toll is required to establish gene expression domains along the dorsal-ventral axis. Pathway activation induces degradation of the IκB inhibitor Cactus, resulting in a ventral-to-dorsal nuclear gradient of the NFκB effector Dorsal. Here, we investigate how cactus modulates Toll signals through its effects on the Dorsal gradient and on Dorsal target genes. Quantitative analysis using a series of loss- and gain-of-function conditions shows that the ventral and lateral aspects of the Dorsal gradient can behave differently with respect to Cactus fluctuations. In lateral and dorsal embryo domains, loss of Cactus allows more Dorsal to translocate to the nucleus. Unexpectedly, cactus loss-of-function alleles decrease Dorsal nuclear localization ventrally, where Toll signals are high. Overexpression analysis suggests that this ability of Cactus to enhance Toll stems from the mobilization of a free Cactus pool induced by the Calpain A protease. These results indicate that Cactus acts to bolster Dorsal activation, in addition to its role as a NFκB inhibitor, ensuring a correct response to Toll signals.
Cas9-mediated excision of Nematostella brachyury disrupts endoderm development, pharynx formation and oral-aboral patterning
Authors: Servetnick Marc D. , Steinworth Bailey , Babonis Leslie S. , Simmons David , Salinas-Saavedra Miguel , Martindale Mark Q. 
Published: July 2017

ABSTRACT
The mesoderm is a key novelty in animal evolution, although we understand little of how the mesoderm arose. brachyury, the founding member of the T-box gene family, is a key gene in chordate mesoderm development. However, the brachyury gene was present in the common ancestor of fungi and animals long before mesoderm appeared. To explore ancestral roles of brachyury prior to the evolution of definitive mesoderm, we excised the gene using CRISPR/Cas9 in the diploblastic cnidarian Nematostella vectensis. Nvbrachyury is normally expressed in precursors of the pharynx, which separates endoderm from ectoderm. In knockout embryos, the pharynx does not form, embryos fail to elongate, and endoderm organization, ectodermal cell polarity and patterning along the oral-aboral axis are disrupted. Expression of many genes both inside and outside the Nvbrachyury expression domain is affected, including downregulation of Wnt genes at the oral pole. Our results point to an ancient role for brachyury in morphogenesis, cell polarity and the patterning of both ectodermal and endodermal derivatives along the primary body axis.
Clinical usefulness of the mDIXON Quant the method for estimation of the salivary gland fat fraction: comparison with MR spectroscopy
Authors: Kise Yoshitaka , Chikui Toru , Yamashita Yasuo , Kobayashi Koji , Yoshiura Kazunori 
Published: July 2017

Objective:
To estimate the fat fraction (FF) in the salivary glands (SGs) by the mDIXON method and the 1H−MR spectroscopy (MRS) method, and to compare the results.

Methods:
16 healthy volunteers were enrolled. mDIXON Quant and MRS (point-resolved spectroscopy: PRESS) with a single TE were employed to measure the FF in the parotid gland (PG) and submandibular gland (SMG). Multiple TEs were applied in 10 volunteers to correct for T 2 decay. In addition, we assumed that the 1.3 ppm peak accounted for 60% of the total fat peak and estimated the FF (MRS all) as a gold standard. On mDIXON Quant images, volumes of interest were set on the bilateral SGs and we obtained the FF (mDIXON) of each volume of interest.

Results:
There was a strong correlation between the results of the mDIXON Quant method and the MRS (single TE) method (R 2 = 0.960, slope = 0.900). Using PRESS with multiple TEs, there was also a strong correlation between FF (mDIXON) and FF (MRS all) (R 2 = 0.963, slope = 1.18). FF (MRS all) was 24.9±12.7% in the PG and 4.5±3.0% in the SMG, while FF (mDIXON) was 29.4±16.2% in the PG and 6.4±4.7% in the SMG. There were no significant differences between the two methods, but the Bland-Altman plot showed that FF (mDIXON) was slightly larger than FF (MRS all) for small FF areas.

Conclusion:
The mDIXON Quant method could be clinically useful for evaluating the FF of SGs, but the absolute values need careful interpretation.

Advance in knowledge:
This study suggested the potential clinical usefulness of the mDIXON Quant method for the SGs.
Third version of vendor-specific model-based iterativereconstruction (Veo 3.0): evaluation of CT image quality in the abdomen using new noise reduction presets and varied slice optimization
Authors: Telesmanich Morgan E , Jensen Corey T , Enriquez Jose L , Wagner-Bartak Nicolaus A , Liu Xinming , Le Ott , Wei Wei , Chandler Adam G , Tamm Eric P 
Published: July 2017

Objective:
To qualitatively and quantitatively compare abdominal CT images reconstructed with a newversion of model-based iterative reconstruction (Veo 3.0; GE Healthcare Waukesha, WI) utilizing varied presetsof resolution preference, noise reduction and slice optimization.

Methods:
This retrospective study was approved by our Institutional Review Board and was Health Insurance Portability and Accountability Act compliant. The raw datafrom 30 consecutive patients who had undergone CT abdomen scanning were used to reconstructfour clinical presets of 3.75mm axial images using Veo 3.0: 5% resolution preference (RP05n), 5%noise reduction (NR05) and 40% noise reduction (NR40) with new 3.75mm “sliceoptimization,” as well as one set using RP05 with conventional 0.625mm “slice optimization” (RP05c).
The images were reviewed by two independent readers in a blinded, randomized manner using a 5-point Likert scale as well as a 5-point comparative scale. Multiple two-dimensional circular regions of interest were defined for noise and contrast-to-noise ratio measurements. Line profiles were drawn across the 7 lp cm–1 bar pattern of the Catphan 600 phantom for evaluation of spatial resolution.

Results:
The NR05 image set was ranked as the best series in overall image quality (mean difference inrank 0.48, 95% CI [0.081–0.88], p = 0.01) and with specific reference to liver evaluation (meandifference 0.46, 95% CI [0.030–0.89], p= 0.03), when compared with the secondbest series ineach category. RP05n was ranked as the best for bone evaluation. NR40 was ranked assignificantly inferior across all assessed categories. Although the NR05 and RP05c image setshad nearly the same contrast-to-noise ratio and spatial resolution, NR05 was generally preferred.
Image noise and spatial resolution increased along a spectrum with RP05n the highest and NR40the lowest. Compared to RP05n, the average noise was 21.01% lower for NR05, 26.88%lower for RP05c and 50.86% lower for NR40.

Conclusion:
Veo 3.0 clinical presets allow for selection of image noise and spatial resolution balance; for contrast-enhanced CT evaluation of the abdomen, the 5% noise reduction preset with 3.75 mm slice optimization (NR05) was generally ranked superior qualitatively and, relative to other series, was in the middle of the spectrum with reference to image noise and spatial resolution.

Advances in knowledge:
To our knowledge, this is the first study of Veo 3.0 noise reduction presets and varied slice optimization. This study provides insight into the behaviour of slice optimization and documents the degree of noise reduction and spatial resolution changes that users can expect across various Veo 3.0 clinical presets. These results provide important parameters to guide preset selection for both clinical and research purposes.
Visceral adipose tissue area measurement at a single level: can it represent visceral adipose tissue volume?
Authors: Noumura Yusuke , Kamishima Tamotsu , Sutherland Kenneth , Nishimura Hideho 
Published: July 2017

Objective:
Measurement of visceral adipose tissue (VAT) needs to be accurate and sensitive to change for risk monitoring. The purpose of this study is to determine the CT slice location where VAT area can best reflect changes in VAT volume and body weight.

Methods:
60 plain abdominal CT images from 30 males [mean age (range) 51 (41–68) years, mean body weight (range) 71.1 (101.9–50.9) kg] who underwent workplace screenings twice within a 1-year interval were evaluated. Automatically calculated and manually corrected areas of the VAT of various scan levels using “freeform curve” region of interest on CT were recorded and compared with body weight changes.

Results:
The strongest correlations of VAT area with VAT volume and body weight changes were shown in a slice 3 cm above the lower margin of L3 with r values of 0.853 and 0.902, respectively.

Conclusion:
VAT area measurement at a single level 3 cm above the lower margin of the L3 vertebra is feasible and can reflect changes in VAT volume and body weight.

Advances in knowledge:
As VAT area at a CT slice 3 cm above the lower margin of L3 can best reflect interval changes in VAT volume and body weight, VAT area measurement should be selected at this location.
Seeking Value Through Deviation? Economic Impacts of IT Overinvestment and Underinvestment
Authors: Ho Joanna , Tian Feng , Wu Anne , Xu Sean Xin 
Published: July 2017

This study addresses the economic impacts of information technology (IT) overinvestment and underinvestment decisions. Based on the view of Red Queen competition in conjunction with institutional theory, we hypothesize that overinvestment and underinvestment in IT have nonlinear performance impacts. Drawing on the idea of management control mechanisms, we further hypothesize that the performance impacts are conditional on ownership concentration. Using a sample of S&P 500 firms, we find that, on average, there is a positive relationship between a firm’s overinvestment in IT and Tobin’s q, although that relationship attenuates at higher levels of overinvestment. However, there is, on average, no relationship between a firm’s underinvestment in IT and its Tobin’s q. Importantly, the payoff for underinvestment becomes positive for companies with founding-family ownership. Implications for research and practice are discussed. The online appendix is available at https://doi.org/10.1287/isre.2017.0710 .
Housing Heterogeneity Dimensions and Their Elements: a Systemic Approach
Authors: Vanags Jānis , Geipele Ineta , Sarkans Auseklis , Usenieks Didzis 
Published: July 2017

AbstractHousing market participants constantly face the housing heterogeneity - the technical and socio-economic differences of dwellings in a certain populated area. Housing heterogeneity often complicates the managerial decision making related to housing transactions, identification and objective evaluation of the quantitative and qualitative aspects of transactions. Housing heterogeneity is an objective phenomenon that implies housing uniqueness - housing distinguishing characteristics divided into specific and interconnected groups within the framework of the research. Most of these differences can be noticed by each market participant, but some of them can be identified only by experienced and professionally trained market participants. Theory and practice have demonstrated that the constituent groups of heterogeneity influence each other and take part in the formation of market value and transaction price of housing units. The increased housing construction intensity, the continuous modernisation of construction technologies and the diversification of building materials used in housing construction, as well as restriction of the building plot of land change the quantitative and qualitative aspects of heterogeneity dimensions. This poses considerable challenges to market participants in the managerial decision making process related to housing transactions. Research results demonstrate that the socio-economic elements of housing heterogeneity are constantly changing under the influence of the dominating factors of the external and internal environment. Therefore, nowadays, housing heterogeneity has become a major cause of information asymmetry, which means that heterogeneity is inherent in the formation of socio-economic market barriers in the housing market.
Trends of Housing Construction Development in Ukraine: Retrospective and Contemporary Situation
Authors: Bibik Natalya , Dril Natalia 
Published: July 2017

Abstract
The construction industry is one of the main components of the national economy of Ukraine as well as many countries worldwide. The volume and level of construction, especially housing, considerably influence further development of all other sectors of economy, and guarantee continuous growth of economic potential and national income. The aim of the research is to analyze the trends of construction development, its historical background and current situation in Ukraine. Literature analysis methods, statistical data processing, historical and logical access methods have been used in the research. The article provides historical overview of housing construction development in Ukraine, current challenges in the industry and solutions to solve them.
Isolation, fatty acid profiles and cryopreservation of marine thraustochytrids from mangrove habitats in Thailand
Authors: Unagul Panida , Suetrong Satinee , Preedanon Sita , Klaysuban Anupong , Gundool Wunna , Suriyachadkun Chanwit , Sakayaroj Jariya 
Published: July 2017

AbstractThraustochytrids, marine protists, have attracted attention as a proven alternative source of polyunsaturated fatty acids (PUFAs). We isolated a high diversity of thraustochytrids from Thailand and tested their potential use in the production of high-value fatty acids. The isolated thraustochytrids can be categorized into seven major groups based on unique morphological features, molecular phylogeny and fatty acid profiles. Two of the seven isolated thraustochytrid groups could potentially be new lineages in the Labyrinthulomycetes. The production of total fatty acid (TFA) from these thraustochytrids ranged from 2.4 to 35.6% (w/w), with biomass varying from 0.3 to 8.9 g l