bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensory Dysfunction, Microbial Infections, and Host Responses in Alzheimer's Disease
Authors: Bathini Praveen , Brai Emanuele , Balin Brian J , Bimler Lynn , Corry David B , Devanand Davangere P , Doty Richard L , Ehrlich Garth D , Eimer William A , Fulop Tamas , Hahn David L , Hammond Christine J , Infanti Joseph , Itzhaki Ruth , Lathe Richard , Little Christopher Scott , McLeod Rima , Moein Shima T , Nelson Amy R , Perry George , Shemesh Or A , Tanzi Rudolph E , Webley Wilmore C , Schultek Nikki M , Alberi Auber Lavinia 
Published: September 2024

AbstractSensory functions of organs of the head and neck allow humans to interact with the environment and establish social bonds. With aging, smell, taste, vision, and hearing decline. Evidence suggests that accelerated impairment in sensory abilities can reflect a shift from healthy to pathological aging, including the development of Alzheimer's disease (AD) and other neurological disorders. While the drivers of early sensory alteration in AD are not elucidated, insults such as trauma and infections can affect sensory function. Herein, we review the involvement of the major head and neck sensory systems in AD, with emphasis on microbes exploiting sensory pathways to enter the brain (the “gateway” hypothesis) and the potential feedback loop by which sensory function may be impacted by central nervous system infection. We emphasize detection of sensory changes as first-line surveillance in senior adults to identify and remove potential insults, like microbial infections, that could precipitate brain pathology.
Hospital employees’ perception of Joint Commission International Accreditation: effect of re-accreditation
Authors: Zhang HongFan , Huang Siou-Tang , Bittle Mark J , Shi LeiYu , Engineer Lilly , Chiu Herng-Chia 
Published: September 2024

Abstract
Joint Commission International (JCI) accreditation is a recognized leader in healthcare accreditation worldwide. It aims to improve quality of care, patient safety, and organizational performance. Many hospitals do not apply for re-accreditation after JCI status expires. Understanding employees’ perceptions of JCI accreditation would benefit hospital management. We aimed to examine whether re-accredited hospital employees perceived more significant benefits and were more likely to recommend JCI to other hospitals than ex-accredited employees. This is a prospective cross-sectional study with a comparison group design. Survey questionnaires, developed from a qualitative study, included perceptions of challenges, benefits, and overall rating of JCI accreditation. An electronic-based questionnaire was distributed to physicians, nurses, medical technicians, and administrative staff in five private Obstetrics and Gynecology hospitals in China, March–April 2023. Descriptive and linear regression analyses were performed. The statistically significant level is P-value &lt;.05. Of 2326 employees, 1854 (79.7%) were included in the study after exclusions, 1195 were re-accredited, and 659 were ex-accredited. Perceptions of JCI accreditation were positive, as both groups reported a mean score &gt;4.0 regarding the overall benefits. Adjusted for covariates, re-accredited employees were more willing to recommend JCI accreditation to other hospitals than ex-accredited employees. Re-accredited employees perceived greater benefits of JCI accreditation and were more willing to recommend it to other hospitals, suggesting that perceived benefits contribute to a desire to maintain and sustain JCI accreditation. Employee participation is vital for its effective implementation. Employees’ perceived challenges and benefits may provide insights for healthcare leaders considering pursuing and reapplying for JCI accreditation.
Metabolite release by nitrifiers facilitates metabolic interactions in the ocean
Authors: Bayer Barbara , Liu Shuting , Louie Katherine , Northen Trent R , Wagner Michael , Daims Holger , Carlson Craig A , Santoro Alyson E 
Published: September 2024

AbstractMicrobial chemoautotroph-heterotroph interactions may play a pivotal role in the cycling of carbon in the deep ocean, reminiscent of phytoplankton-heterotroph associations in surface waters. Nitrifiers are the most abundant chemoautotrophs in the global ocean, yet very little is known about nitrifier metabolite production, release, and transfer to heterotrophic microbial communities. To elucidate which organic compounds are released by nitrifiers and potentially available to heterotrophs, we characterized the exo- and endometabolomes of the ammonia-oxidizing archaeon Nitrosopumilus adriaticus CCS1 and the nitrite-oxidizing bacterium Nitrospina gracilis Nb-211. Nitrifier endometabolome composition was not a good predictor of exometabolite availability, indicating that metabolites were predominately released by mechanisms other than cell death/lysis. Although both nitrifiers released labile organic compounds, N. adriaticus preferentially released amino acids, particularly glycine, suggesting that its cell membranes might be more permeable to small, hydrophobic amino acids. We further initiated co-culture systems between each nitrifier and a heterotrophic alphaproteobacterium, and compared exometabolite and transcript patterns of nitrifiers grown axenically to those in co-culture. In particular, B vitamins exhibited dynamic production and consumption patterns in nitrifier-heterotroph co-cultures. We observed an increased production of vitamin B2 and the vitamin B12 lower ligand dimethylbenzimidazole by N. adriaticus and N. gracilis, respectively. In contrast, the heterotroph likely produced vitamin B5 in co-culture with both nitrifiers and consumed the vitamin B7 precursor dethiobiotin when grown with N. gracilis. Our results indicate that B vitamins and their precursors could play a particularly important role in governing specific metabolic interactions between nitrifiers and heterotrophic microbes in the ocean.
Prevalence of streptomycin and tetracycline resistance and increased transmissible third-generation cephalosporin resistance in Salmonella enterica isolates derived from food handlers in Japan from 2006 to 2021
Authors: Ohata Natsuki , Noda Mamoru , Ohta Kenji , Hatta Moritaka , Nakayama Tatsuya 
Published: September 2024

Abstract

Aims
The increasing prevalence of AmpC β-lactamase (AmpC)- and extended-spectrum β-lactamase (ESBL)- producing food pathogens is a serious public health concern. AmpC- and ESBL-producing Salmonella species pose a high risk of food contamination. This study aimed to investigate changes in the prevalence of Salmonella among food handlers in Japan from 2006 to 2021 using 100 randomly selected isolates from 2006, 2012, 2018, and 2021 with different serotypes and antimicrobial resistance patterns.

Methods and results
The average Salmonella isolation rate was 0.070% (19 602/27 848 713). Serotyping revealed that the most common serotypes were Enteritidis in 2006, Infantis in 2012, Agoueve/Cubana in 2018, and Schwarzengrund in 2021. Antimicrobial susceptibility testing showed that Salmonella isolates exhibited the highest resistance to streptomycin (&lt;40%), followed by tetracycline (&lt;20%–40%). Moreover, 6% of the Salmonella isolates produced cephalosporinases with the blaCMY-2, blaCTX-M-14, and blaTEM genes. The annual incidence of cephalosporin resistance has increased. Plasmid conjugation assays revealed that cephalosporin-resistant Salmonella spp. transmitted their resistance to Escherichia coli. Additionally, plasmid genome analysis showed that the insertion sequence IS26 was encoded in the upstream and downstream regions of blaCTX-M-14 and qnrS1 in the IncHI1 plasmid, which could be transmitted to other bacteria.

Conclusions
The tested Salmonella isolates showed high resistance to specific antibiotics, with differences in resistance depending on the serotype. Further increase and spread of transmissible cephalosporin-resistant strains should be noted.
The I4790K mutation of the ryanodine receptor is responsible for anthranilic diamide resistance in field populations of Plutella xylostella (Lepidoptera: Plutellidae)
Authors: Pudasaini Rameshwor , Chang Cheng , Chen Mu-Hsin , Dai Shu-Mei 
Published: September 2024

Abstract
Insecticide resistance in Plutella xylostella (Linnaeus) (Lepidoptera: Plutellidae) is a major constraint on the global production of cruciferous crops. For effective management of insecticide resistance, it is necessary to develop a molecular detection tool for predicting insecticide resistance levels based on the mutation frequency of target sites. In this study, a susceptible strain (SHggt) of P. xylostella was subjected to chlorantraniliprole and tetraniliprole selection under laboratory conditions to obtain the CHLSel and TETSel strains, respectively, to determine their resistance development, cross-resistance and mutation frequencies of the P. xylostella ryanodine receptor (PxRyR). In addition, the tetraniliprole resistance and the mutation frequencies of the PxRyR from 7 field populations were evaluated. Continuous selection over 30 generations resulted in resistance ratios (RRs) of 7,073.2-fold and 6,971.0-fold for the CHLSel and TETSel strains, respectively, and thousandfold increases in cross-resistance to unexposed diamides, e.g., cyantraniliprole and flubendiamide, were observed. For the field populations, three out of seven populations have developed more than thousandfold resistance to tetraniliprole. Among the three investigated target site mutations in PxRyR, only I4790K was detected in both laboratory-selected strains. However, 2 mutations, I4790K and G4946E, were detected in field populations. A positive correlation between RRs and K allele frequencies was observed in the laboratory-selected/relaxed strains and field populations of P. xylostella. These results suggest a possible link between the development of anthranilic diamide resistance and the frequency of the PxRyR I4790K mutation, which can be used to develop effective strategies for diamide resistance management in P. xylostella.
Molecular identification of predation on the Dubas bug (Hemiptera: Tropiduchidae) in Oman date palms: density-dependent response to prey
Authors: Athey Kacie J , Chapman Eric G , Al-Khatri Salem , Moktar Abdel Moneim , Obrycki John J 
Published: September 2024

Abstract
The date palm (Phoenix dactylifera L.) (Arecales: Arecaceae) is the most economically important crop in Oman with an annual production of &gt;360,000 tons of fruit. The Dubas bug (Ommatissus lybicus de Bergevin) (Hemiptera: Tropiduchidae) is one of the major pests of date palms, causing up to a 50% reduction in fruit production. Across the course of 2 seasons, a variety of arthropod predators living in the date palm canopy were investigated for possible biological control of Dubas bugs, given the growing interest in nonchemical insect pest control in integrated pest management. We collected ~6,900 arthropod predators directly from date palm fronds from 60 Omani date palm plantations and tested them for Dubas bug predation using PCR-based molecular gut content analysis. We determined that ≥56 species of arthropod predators feed on the Dubas bug. We found that predatory mites, ants, and the entire predator community combined showed a positive correlation between predation detection frequency and increasing Dubas bug density. Additionally, there was a significant impact of season on gut content positives, with the spring season having a significantly higher percentage of predators testing positive for Dubas bug, suggesting this season could be the most successful time to target conservation biological control programs utilizing a diverse suite of predators.
Preoperative prediction of early mortality after surgery for spinal metastases
Authors: Kamoda Hiroto , Tsukanishi Toshinori , Kinoshita Hideyuki , Hagiwara Yoko , Endo Yuji , Takahashi Hiroki , Takeda Kosuke , Hirashima Tetsuya , Ishii Takeshi , Yonemoto Tsukasa 
Published: September 2024

Abstract

Objective
The objective of this study was to provide a convenient preoperative prediction of the risk of early postoperative mortality.

Materials and methods
This retrospective study included patients who underwent surgery for spinal metastasis at our hospital between 2009 and 2021. Preoperative blood test data of all patients were collected, and the survival time was calculated by dividing the blood data. A multivariate analysis was conducted using a Cox proportional hazards model to identify prognostic factors.

Results
The study population included 83 patients (average: 64.5 years), 22 of whom died within 3 months. The most common lesion was the thoracic spine, and incomplete paralysis was observed in 57 patients. The surgical methods included posterior implant fixation (n = 17), posterior decompression (n = 31), and posterior decompression with fixation (n = 35). In the univariate analysis, the presence of abnormal values was significantly associated with postoperative survival in six preoperative blood collection items (hemoglobin, C-reactive protein, albumin, white blood cell, gamma-glutamyl transpeptidase, and lactate dehydrogenase). In a multivariate analysis, four test items (hemoglobin, C-reactive protein, white blood cell, and lactate dehydrogenase) were identified as independent prognostic factors.
Comparing cases with ≥3 abnormal values among the above four items (high-risk group; n = 23) and those with ≤2 (low-risk group; n = 60), there was a significant difference in survival time. In addition, it was possible to predict cases of early death within 3 months after surgery with 73% sensitivity and 89% specificity.

Conclusions
The study showed that four preoperative blood test abnormalities (hemoglobin, C-reactive protein white blood cell, and lactate dehydrogenase) indicated the possibility of early death within 3 months after surgery.
Regeneration and colonization abilities of invasive and native Myriophyllum species under different fragment types and lengths
Authors: Zou Min , Lin Xiao-Wen , Wu Xiao-Dong , Qin Yuan , Ge Xu-Guang , Hou Jian-Jun , Li Xiao-Xia , Peng Shuang 
Published: September 2024

Abstract
Alien invasive species usually have strong regeneration and colonization abilities. However, whether invasive species have advantages in terms of regeneration and colonization abilities over native species requires further exploration. In this study, the effects of fragment types (with and without apical tips) and lengths (5, 10 and 15 cm) on the regeneration and colonization abilities of the invasive Myriophyllum aquaticum and native M. spicatum in China were studied. Fragments of M. aquaticum and M. spicatum without apical tips had an advantage in branch formation, and their regeneration ability was stronger than that of fragments with apical tips. With longer initial fragments, the root length of M. aquaticum was longer and its colonization ability was stronger. This resulted in an increase in plant length, stem node number and biomass, with an increase in fragment length. However, the colonization ability of M. spicatum was not stronger with longer fragments. On the whole, native M. spicatum had stronger regeneration and colonization abilities than the invasive species M. aquaticum. However, M. aquaticum had a higher survival rate and plant length, enabling it to quickly occupy living spaces. Our results suggest that management needs to be strengthened for both M. aquaticum and M. spicatum to avoid biological invasion.
Child mental health treatment access and retention in integrated primary care and traditional outpatient services
Authors: Joseph Hannah L , Zhang Li Fang , Best Candace , Bancroft Christina , James Madison , Kapoor Shreeti , Drescher Christopher F , Davis Catherine L 
Published: September 2024

Abstract

Introduction
There are disparities in child mental health treatment access and treatment retention in terms of race and ethnicity, socioeconomic status (SES), and insurance coverage. Institutions have invested in the integrated primary care (IPC) treatment model with the goal of improving treatment access and promoting child mental health equity.

Objective
This study compared treatment attendance in an outpatient psychiatry clinic (OPC) versus an IPC clinic to assess whether the IPC was associated with reduced disparities in access to care and treatment retention.

Methods
This study assessed whether there were differences in who is connected to care from the intake appointment to first follow-up appointment.

Results
Results showed that the IPC clinic served a more diverse patient population than the OPC clinic in terms of SES, race, and ethnicity. Differences in treatment attendance in the IPC and OPC were also found. After controlling for race, ethnicity, insurance, and distance from patient’s home zip code to clinic, the IPC treatment setting was associated with poorer intake and follow-up appointment attendance.

Conclusions
The IPC model may be more accessible to historically underserved youth, but the treatment setting does not inherently eliminate disparities in child mental health treatment retention. Replication of this study has the potential to contribute to the external validity of study findings, improve quality assurance policies, and develop equitable workflow policies. Future research is needed to identify factors that can improve treatment attendance for populations who face greater retention barriers and to shine light on ways that healthcare systems may inadvertently maintain disparity in treatment retention.
Twenty-three new Heartbeat Star systems discovered based on TESS data
Authors: Li Min-Yu , Qian Sheng-Bang , Zhou Ai-Ying , Zhu Li-Ying , Liao Wen-Ping , Zhao Er-Gang , Shi Xiang-Dong , Li Fu-Xing , Sun Qi-Bin 
Published: September 2024

ABSTRACT
Heartbeat stars (HBSs) are ideal astrophysical laboratories to study the formation and evolution of binary stars in eccentric orbits and the internal structural changes of their components under strong tidal action. We discover 23 new HBSs based on TESS photometric data. The orbital parameters, including orbital period, eccentricity, orbital inclination, argument of periastron, and epoch of periastron passage of these HBSs, are derived by using a corrected version of Kumar et al.'s model based on the Markov Chain Monte Carlo (MCMC) method. The preliminary results show that these HBSs have orbital periods in the range from 2.7 to 20 d and eccentricities in the range from 0.08 to 0.70. The eccentricity-period relation of these objects shows a positive correlation between eccentricity and period and also shows the existence of orbital circularization. The Hertzsprung–Russell diagram shows that the HBSs are not all located in a particular area. The distribution of the derived parameters suggests a selection bias within the TESS survey towards HBSs with shorter periods. These objects are a very useful source to study the structure and evolution of eccentricity orbit binaries and to extend the TESS HBS catalog.
Separating states in astronomical sources using hidden Markov models: with a case study of flaring and quiescence on EV Lac
Authors: Zimmerman Robert , van Dyk David A , Kashyap Vinay L , Siemiginowska Aneta 
Published: September 2024

ABSTRACT
We present a new method to distinguish between different states (e.g. high and low, quiescent and flaring) in astronomical sources with count data. The method models the underlying physical process as latent variables following a continuous-space Markov chain that determines the expected Poisson counts in observed light curves in multiple passbands. For the underlying state process, we consider several autoregressive processes, yielding continuous-space hidden Markov models of varying complexity. Under these models, we can infer the state that the object is in at any given time. The continuous state predictions from these models are then dichotomized with the help of a finite mixture model to produce state classifications. We apply these techniques to X-ray data from the active dMe flare star EV Lac, splitting the data into quiescent and flaring states. We find that a first-order vector autoregressive process efficiently separates flaring from quiescence: flaring occurs over 30 per cent–40 per cent of the observation durations, a well-defined persistent quiescent state can be identified, and the flaring state is characterized by higher plasma temperatures and emission measures.
Simulating cardiac fluid dynamics in the human heart
Authors: Davey Marshall , Puelz Charles , Rossi Simone , Smith Margaret Anne , Wells David R , Sturgeon Gregory M , Segars W Paul , Vavalle John P , Peskin Charles S , Griffith Boyce E 
Published: September 2024

Abstract
Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin valve leaflets. There has been longstanding scientific, engineering, and medical interest in creating mathematical models of the heart that capture, explain, and predict these fluid–structure interactions (FSIs). However, existing computational models that account for interactions among the blood, the actively contracting myocardium, and the valves are limited in their abilities to predict valve performance, capture fine-scale flow features, or use realistic descriptions of tissue biomechanics. Here we introduce and benchmark a comprehensive mathematical model of cardiac FSI in the human heart. A unique feature of our model is that it incorporates biomechanically detailed descriptions of all major cardiac structures that are calibrated using tensile tests of human tissue specimens to reflect the heart’s microstructure. Further, it is the first FSI model of the heart that provides anatomically and physiologically detailed representations of all four cardiac valves. We demonstrate that this integrative model generates physiologic dynamics, including realistic pressure–volume loops that automatically capture isovolumetric contraction and relaxation, and that its responses to changes in loading conditions are consistent with the Frank–Starling mechanism. These complex relationships emerge intrinsically from interactions within our comprehensive description of cardiac physiology. Such models can serve as tools for predicting the impacts of medical interventions. They also can provide platforms for mechanistic studies of cardiac pathophysiology and dysfunction, including congenital defects, cardiomyopathies, and heart failure, that are difficult or impossible to perform in patients.