bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient experiences with care across various types of mental health care: Questionnaire development, measurement invariance, and patients' reports
Authors: Bruyneel Luk , Van Houdt Sabine , Coeckelberghs Ellen , Sermeus Walter , Tambuyzer Else , Cosemans Peter , Peeters Gert , Van den Broeck Kris , Weeghmans Ilse , Vanhaecht Kris 
Published: October 2017

AbstractTo describe the development, validation, and findings of a patient experience questionnaire across 7 types of residential and ambulatory mental health care services. Thirty‐five items were hypothesized to cover information, participation, therapeutic relationship, personalized care, organization and collaboration, safety, patient rights, outcomes of care, and discharge preparation and after‐care. Also included were 2 overall rating items (scoring and recommending the organization). This Dutch questionnaire was applied in 79 organizations in Belgium (N patients = 5,168). Exploratory structural equation modelling was conducted on a random split‐half sample to examine dimensionality. Confirmatory factor analysis and multiple group confirmatory factor analyses were conducted on the holdout sample to confirm dimensionality and assess measurement invariance across type of service and patient characteristics. Multilevel logistic regression models linking subscale top box scores to overall rating items were used to assess criterion validity. The hypothesized dimensionality was partly confirmed, and configural and scalar invariance were demonstrated across types of organizations and patient characteristics. Subscale scores were significantly associated with overall ratings. Process evaluation showed that participating organizations strongly support continued use of this questionnaire. This validated patient experience questionnaire supports comparison across organizations from different types of services to improve the quality of mental health care.
Challenges of post‐authorization safety studies: Lessons learned and results of a French study of fentanyl buccal tablet
Authors: Gavrielov‐Yusim Natalie , Bidollari Ilda , Kaplan Sigal , Bartov Netta 
Published: October 2017

AbstractPurposeRecruiting and retaining participants in real‐world studies that collect primary data are challenging. This article illustrates these challenges using a post‐authorization safety study (PASS) to assess adverse events (AEs) experienced with fentanyl buccal tablet (FBT) over 3 months of treatment.MethodsThis was an observational, prospective, multicenter study in France conducted over 1 year. The study employed primary data collection in FBT‐treated patients and their treating physicians via a site qualification questionnaire and patient log completed by physicians and a questionnaire and pain diary completed by patients. Strategies to increase participation included reminders, newsletters, frequent follow‐up telephone calls, and reducing the extent of data collected.ResultsOf the 1118 physicians contacted who returned the participation form or responded to a telephone call, only 128 expressed willingness to participate. Key reasons for non‐participation were lack of interest (69.7%) and FBT not being used in practice by the contacted physician (25.1%). Overall, 224 patients were screened by 31 physicians, and 97 were enrolled. Key reasons for patient non‐inclusion were unwillingness or inability to complete the patient AE diary or questionnaire (40.9% [52/127]) and patients' decision (33.9% [43/127]).ConclusionsDespite efforts to increase participation, enrollment in this study was low. Recruitment and retention methods are limited in their capacity to optimally execute a primary data collection in a PASS. For a PASS to provide reliable and valid information on medication use, involvement from health care agencies, regulators, and pharmaceutical companies is needed to establish their importance, drive study participation, and reduce patient withdrawal.
Quantification of solvent water and hydration dynamic of thermo‐sensitive microgel by dielectric spectroscopy
Authors: Yang Man , Su Wenjuan , Zhao Kongshuang 
Published: October 2017

ABSTRACTThe hydration of natural or synthetic macromolecules is of fundamental importance in our understanding of their structure and stability. Quantification of hydration water can promote the understanding to many complex biological mechanisms such as protein folding, as well as the dynamics and conformation of polymers. An approach to quantification of solvent water was developed by dielectric spectroscopy. Dielectric behaviors of PNIPAM microgels with different crosslink density distribution were measured in the range of 0.5–40 GHz and 15–50. An obvious relaxation process caused by free and bound water was found. Dielectric parameters of free and bound water show that the crosslink density distribution does not affect the volume phase transition temperature of microgels, but significantly influence the orientation dynamics of the solvent water. We found that the three kinds of microgel can be distinguished by the dielectric parameters of the bound water. In addition, the number of water in and outside microgel during the volume phase transition process was quantitatively calculated for the first time. This study provides the possibility for the quantification of water in complex biological process. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2017, 55, 1859–1864
Characterization of UDP‐glucuronosyltransferase genes and their possible roles in multi‐insecticide resistance in Plutella xylostella (L.)
Authors: Li Xiuxia , Shi Haiyan , Gao Xiwu , Liang Pei 
Published: October 2017

AbstractBACKGROUNDUridine diphosphate‐glucuronosyltransferases (UGTs), as multifunctional detoxification enzymes, play important roles in the biotransformation of various compounds. However, their roles in insecticide resistance are still unclear. This study presents a genome‐wide identification of the UGTs in diamondback moth, Plutella xylostella (L.), a notorious insect pest of cruciferous crops worldwide. The possible roles of these UGTs in insecticide resistance were evaluated.RESULTSA total of 21 putative UGTs in P. xylostella were identified. Quantitative real‐time polymerase chain reaction (PCR)‐based analyses showed that all the UGT genes were expressed in all tested developmental stages and tissues. Bioassay results indicated that a field‐collected population (BL) was resistant to 9 of 10 commonly used insecticides, and 10 of 21 UGT mRNAs were upregulated in the BL population. Exposure to the LC50 of each insecticide affected the expression of most UGT genes. Among these, the expression levels of UGT40V1, UGT45B1 and UGT33AA4 were induced by more than five insecticides, whereas indoxacarb and metaflumizone significantly repressed the expression of most UGT genes.CONCLUSIONUGTs may play important roles in the metabolism of commonly used insecticides in P. xylostella. These findings provide valuable information for further research on the physiological and toxicological functions of specific UGT genes in P. xylostella. © 2017 Society of Chemical Industry
The effect of Rosa (L. Rosa canina) on the incidence of urinary tract infection in the puerperium: A randomized placebo‐controlled trial
Authors: Seifi Mahdieh , Abbasalizadeh Shamsi , Mohammad‐Alizadeh‐Charandabi Sakineh , Khodaie Laleh , Mirghafourvand Mojgan 
Published: October 2017

Urinary tract infection (UTI) is an infection that can occur in any area of the urinary tract which is characterized by a positive urine culture (U/C). The risk of UTI following cesarean section (CS) increases due to procedures such as catheterization. In vitro studies have demonstrated the effect of Rosa canina fruit in preventing Escherichia coli growth. This study was conducted to determine the effect of R. canina fruit in preventing the incidence of UTI in women following CS. This triple‐blind randomized clinical trial was conducted in 2016 on 400 women following CS with negative U/C in Alzahra and Taleghani educational hospitals in the city of Tabriz‐Iran. Participants were assigned into two groups of 200 women using block randomization. Each group received a twice daily dose of 500 mg capsules containing R. canina or placebo from the second day after CS for 20 days. Women were assessed by U/C on the 7th–10th and 20th days following CS. UTI was significantly lower in the intervention group compared with the control in the follow‐ups conducted on the 7th–10th days (odds ratio = 0.22; confidence interval 95% [0.07, 0.67]; p = .006) and 20th day (odds ratio = 0.32; confidence interval 95% [0.14, 0.75]; p = .008). But the incidence of cystitis in the two groups was not statistically significant (p > .05). R. canina fruit capsules were able to reduce the incidence of UTI after CS. Thus, it is likely that administration of this medication can promote maternal health following CS.
Identification of gelsemine metabolites in rat liver S9 by high‐performance liquid chromatography/quadrupole‐time‐of‐flight mass spectrometry
Authors: Yang Kun , Huang Ya‐Jun , Xiao Sa , Liu Yan‐Chun , Sun Zhi‐Liang , Liu Yi‐Song , Tang Qi , Liu Zhao‐Ying 
Published: October 2017

RationaleGelsemine has been extensively studied because of its anti‐tumor, immunomodulatory, insecticidal itching and other significant effects. However, limited information on the pharmacokinetics and metabolism of gelsemine has been reported. Therefore, the purpose of the present study was to investigate the in vitro metabolism of gelsemine in rat liver S9 by using rapid and accurate high‐performance liquid chromatography/ quadrupole‐time‐of‐flight mass spectrometry (HPLC/QqTOF‐MS).MethodsThe incubation mixture was processed with 15% trichloroacetic acid. Multiple scans of gelsemine metabolites and accurate mass measurements were automatically performed simultaneously through data‐dependent acquisition in only 30 min. The structural elucidations of these metabolites were performed by comparing their changes in accurate molecular masses and product ions with those of the parent drug.ResultsFive metabolites of gelsemine were identified in rat liver S9. Of these, four metabolites of gelsemine were identified for the first time. The present results showed that the metabolic pathways of gelsemine are oxidation, demethylation, and dehydrogenation in rat liver S9.ConclusionsIn this study, metabolites of gelsemine in liver S9 were identified and elucidated firstly using the HPLC/QqTOF‐MS method. The proposed metabolic pathways of gelsemine in liver S9 will provide a basis for further studies of the in vivo metabolism of gelsemine in animals and humans.
The magnitude and significance of sediment oxygen demand in gravel spawning beds for the incubation of salmonid embryos
Authors: Sear D. A. , Pattison I. , Collins A. L. , Smallman D. J. , Jones J. I. , Naden P. S. 
Published: October 2017

AbstractGlobally, salmon populations are under pressure and in those where numbers are severely depleted, density independent factors such as the accumulation of fine sediment and subsequent mortality of incubating embryos are critical factors in their conservation. Although progress has been made in identifying the processes by which fine sediment can lead to embryo mortality, this has focussed on the physical blockage of gravel pores. This paper presents new knowledge on the role of sediment‐associated organic matter in controlling the supply of dissolved oxygen to incubating salmon embryos within gravel river beds. We report a new approach to the measurement of sediment oxygen demand (SOD) from interstitial sediments accumulated within salmon redds and demonstrate this across a range of salmon river types. The effects of varying SOD on dissolved oxygen supply to incubating salmon embryos are quantified for the first time, using the physically based Sediment Intrusion and Dissolved Oxygen (SIDO‐UK) model. The results reveal the importance of the mass of accumulating sediment and sediment consumption rates (sediment oxygen consumption [SOC]), which constitute the overall SOD over time for a particular sediment sample. Higher SOC result in reductions in dissolved oxygen that are deleterious to salmonids; however, these are subordinate to the effects of sediment mass. Larger quantities of sediment accumulating within the redd not only create a higher SOD but also physically block the pores within the gravels, leading to a more drastic decline in oxygen supply through the combined effects of reduced seepage velocity and dissolved oxygen concentration. We seek to generalize the results by exploring the influence of catchment characteristics on field measures of SOD and SOC. This work makes a significant and novel contribution to improving our fundamental understanding of hyporheic processes within salmonid spawning gravels whilst providing resource managers with evidence of the deleterious effects of sediment‐associated organic matter on salmon recruitment.
A review of tensor‐based methods and their application to hospital care data
Authors: Giordani Paolo , Kiers Henk A.L. 
Published: October 2017

In many situations, a researcher is interested in the analysis of the scores of a set of observation units on a set of variables. However, in medicine, it is very frequent that the information is replicated at different occasions. The occasions can be time‐varying or refer to different conditions. In such cases, the data can be stored in a 3‐way array or tensor. The Candecomp/Parafac and Tucker3 methods represent the most common methods for analyzing 3‐way tensors. In this work, a review of these methods is provided, and then this class of methods is applied to a 3‐way data set concerning hospital care data for a hospital in Rome (Italy) during 15 years distinguished in 3 groups of consecutive years (1892–1896, 1940–1944, 1968–1972). The analysis reveals some peculiar aspects about the use of health services and its evolution along the time.
Metal–Organic Frameworks and Their Composites: Synthesis and Electrochemical Applications
Authors: Yi Fei‐Yan , Zhang Rui , Wang Hailong , Chen Li‐Feng , Han Lei , Jiang Hai‐Long , Xu Qiang 
Published: October 2017

AbstractAs a youthful family of crystalline porous materials, metal–organic frameworks (MOFs), assembled by inorganic vertices (metal ions or clusters) and organic ligands, feature ultrahigh porosity, high surface area, and synthetic and structural tailorability, along with relatively easy synthesis, making them excellent candidates for a large number of applications. Recently, increasing research interest in the electrochemical fields with regard to the environment and energy has been received. Lots of MOFs have been designed, prepared, and used in electrochemical applications, exhibiting fascinating performances. Here, the rational fabrication of electrochemical‐application‐directed functional MOFs and MOF composites is appraised. The synthetic strategies for the enhancement of corresponding MOF electrochemical behaviors are summarized and the relationship between structure and electrochemical performance is discussed. It is expected that the summary will be helpful for the future development of related MOFs and MOF composites with an excellent electrochemical performance.
Concise Review: Emerging Principles from the Clinical Application of Chimeric Antigen Receptor T Cell Therapies for B Cell Malignancies
Authors: Jain Michael D. , Davila Marco L. 
Published: October 2017

AbstractGene-engineered T cell therapies are soon to be United States Food and Drug Administration (FDA) approved for at least two types of B cell malignancies in pediatric and adult patients, in the form of CD19 targeted chimeric antigen receptor T (CAR T) cell therapy. This represents a triumph of a true bench to bedside clinical translation of a therapy that was conceived of in the early 1990s. Clinical results have demonstrated efficacious responses in patients with the CD19 positive diseases B cell acute lymphoblastic leukemia and diffuse large B cell lymphoma. However, significant challenges have emerged, including worrisome immune-related toxicities, therapy resistance, and understanding how to administer CD19 CAR T cells in clinical practice. Although much remains to be learned, pioneering clinical trials have led to foundational insights about the clinical translation of this novel therapy. Here, we review the “lessons learned” from the pre-clinical and human experience with CAR T cell therapy.
“We do not know what is the real story anymore”: Curricular contextualization principles that support indigenous students in understanding natural selection
Authors: Sánchez Tapia Ingrid , Krajcik Joseph , Reiser Brian 
Published: October 2017

AbstractWe propose a process of contextualization based on seven empirically derived contextualization principles, aiming to provide opportunities for Indigenous Mexican adolescents to learn science in a way that supports them in fulfilling their right to an education aligned with their own culture and values. The contextualization principles we empirically derived account for Nahua students' cultural cognition, socialization, and cultural narratives, thus supporting Indigenous students in navigating the differences between their culture and the culture and language of school while learning complex science concepts such as natural selection. The process of curricular contextualization we propose is empirically driven, taking culture and socialization into account by using multiples sources (cognitive tasks to explore teleology, ethnographic observation of students' community and classroom, and interviews with students and community members) and builds on the scholarship in Culturally Relevant Pedagogy and Indigenous Education. We used these principles to redesign a middle school biology unit on natural selection to make it more culturally relevant for Nahua students. The enactment of this unit resulted in students being engaged in science learning and achieving significant learning gains. The significance of this study lies in presenting evidence that learning science in culturally relevant ways supports the learning of challenging biology concepts. We provide evidence that Western science can be learned in ways that are more aligned with Indigenous students' Traditional Indigenous Knowledge, thus informing the implementation of educational policies aiming to improve the quality of secondary education for Indigenous adolescents. Our proposed contextualization principles can benefit students of all cultural identities who feel that their religion, language, or traditional knowledge are not aligned with school science, facilitating their access to culturally relevant science education.
Does site of cord insertion increase risk of adverse outcome, twin‐to‐twin transfusion syndrome and discordant growth in monochorionic twin pregnancy?
Authors: Couck I. , Mourad Tawfic N. , Deprest J. , De Catte L. , Devlieger R. , Lewi L. 
Published: October 2017

ObjectivesIt is not currently well known to what extent the sites of cord insertion influence the risk of complicated outcome in monochorionic twin pregnancy. The objectives of this study were to examine whether the sites of cord insertion, as determined on prenatal ultrasound examination, affect the risks of adverse outcome, twin‐to‐twin transfusion syndrome (TTTS) and discordant growth, and whether discordance in insertion sites or velamentous insertion in one or both twins best predicts risk.MethodsThis was a retrospective cohort study of monochorionic diamniotic twin pregnancies followed from the first trimester. The cohort was divided into three groups of increasing discordance in cord insertion sites: concordant (normal–normal; marginal–marginal; velamentous–velamentous), intermediate (normal–marginal; marginal–velamentous) and discordant (normal–velamentous). Adverse outcome was defined as fetal or neonatal loss or birth prior to 32 weeks. The associations of adverse outcome, TTTS and discordant growth were assessed using logistic regression analysis with the following predictors: the three groups of insertion sites and velamentous insertion in one or both twins.ResultsIncluded in the analysis were 518 pregnancies. On univariate analysis, both discordant and velamentous insertions in one twin increased the risk of adverse outcome, TTTS and discordant growth. Intermediate insertion only increased the risk of discordant growth. Velamentous insertion in both twins increased the risk of adverse outcome and TTTS, but not of discordant growth. Multivariate logistic regression analysis showed velamentous insertion in one or both twins to independently predict adverse outcome and TTTS. For discordant growth, both intermediate/discordant and velamentous cord insertion in one twin were independent predictors.ConclusionsVelamentous cord insertion in one or both twins increases the risk of adverse outcome and TTTS, irrespective of discordance in the insertion sites, whereas the risk of discordant growth is determined by both discordance in insertion sites and velamentous cord insertion in one twin. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
Safe Surgery for All: Early Lessons from Implementing a National Government‐Driven Surgical Plan in Ethiopia
Authors: Burssa Daniel , Teshome Atlibachew , Iverson Katherine , Ahearn Olivia , Ashengo Tigistu , Barash David , Barringer Erin , Citron Isabelle , Garringer Kaya , McKitrick Victoria , Meara John , Mengistu Abraham , Mukhopadhyay Swagoto , Reynolds Cheri , Shrime Mark , Varghese Asha , Esseye Samson , Bekele Abebe 
Published: October 2017

AbstractRecognizing the unmet need for surgical care in Ethiopia, the Federal Ministry of Health (FMOH) has pioneered innovative methodologies for surgical system development with Saving Lives through Safe Surgery (SaLTS). SaLTS is a national flagship initiative designed to improve access to safe, essential and emergency surgical and anaesthesia care across all levels of the healthcare system. Sustained commitment from the FMOH and their recruitment of implementing partners has led to notable accomplishments across the breadth of the surgical system, including but not limited to: (1) Leadership, management and governance—a nationally scaled surgical leadership and mentorship programme, (2) Infrastructure—operating room construction and oxygen delivery plan, (3) Supplies and logistics—a national essential surgical procedure and equipment list, (4) Human resource development—a Surgical Workforce Expansion Plan and Anaesthesia National Roadmap, (5) Advocacy and partnership—strong FMOH partnership with international organizations, including GE Foundation’s SafeSurgery2020 initiative, (6) Innovation—facility‐driven identification of problems and solutions, (7) Quality of surgical and anaesthesia care service delivery—a national peri‐operative guideline and WHO Surgical Safety Checklist implementation, and (8) Monitoring and evaluation—a comprehensive plan for short‐term and long‐term assessment of surgical quality and capacity. As Ethiopia progresses with its commitment to prioritize surgery within its Health Sector Transformation Plan, disseminating the process and outcomes of the SaLTS initiative will inform other countries on successful national implementation strategies. The following article describes the process by which the Ethiopian FMOH established surgical system reform and the preliminary results of implementation across these eight pillars.