bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: ALIPHATISCHE 1,2,3‐TRIKETONE DURCH OZONOLYSE VON DIALKYL‐1,4‐BENZOCHINONEN
Authors: SCHILL GOTTFRIED , LOGEMANN ENNO , ZUERCHER CLEMENS 
Published: March 2016

AbstractDie Ozonolyse der Benzochinone (I) in Äthylacetat/Methanol unterhalb 0°C und anschließende Reduktion des Ozonids mit Dimethylsulfid führen zum Heptakosatrion (II).
ChemInform Abstract: MECHANISMUS DER REDOX‐ZERS. VON OXYMERCURIERTEM CIS‐2‐BUTEN IN WAESSRIGER LOESUNG
Authors: MATSUO M. , SAITO Y. 
Published: March 2016

Abstractcis‐2‐Buten (II) liefert bei der Oxymercurierung unter schonenden Bedingungen Methyläthylketon (I), während unter energischeren Bedingungen Produkt wie (III) und (IV) erhalten werden, deren Bildung durch Verwendung deuterierter Reagentien untersucht wird.
ChemInform Abstract: NEUE VERBINDUNGEN, DIE OPTISCHE TRENNUNG VON D,L‐ALPHA‐BENZAMIDO‐4‐HYDROXY‐3‐METHOXYDIHYDROZIMTSAEURE, EINER VORSTUFE DES (‐)‐3,4‐DIHYDROXY‐PHENYLALANINS
Authors: SCHWAN TH. J. , BURCH H. A. 
Published: March 2016

AbstractDie racemische Carbonsäure (I) läßt sich mit Hilfe von Dehydroabietylamin in die optisch aktiven Isomeren aufspalten.
ChemInform Abstract: AMIDINE 3. MITT. THIOHARNSTOFFE MIT ANTIHYPERTENSIVER WIRKUNG
Authors: LOEV B. , BENDER P. E. , BOWMAN H. , HELT A. , MCLEAN R. , JEN T. 
Published: March 2016

AbstractAus den entsprechenden Aminen (I) erhält man mit Rhodanid die Thioharnstoffe (II) bzw. entsprechende Folgeprodukte (III) und (IV).
ChemInform Abstract: ELEKTROCHEMISCHE RED. VON ZWISCHENSTUFEN BEI BLDG. VON VITAMIN B6 2. MITT. RED. VON 2‐METHOXYMETHYL‐3‐NITRO‐4‐METHYL‐5‐CYAN‐6‐CHLOR‐PYRIDIN
Authors: LACAN M. , TABAKOVIC I. , HRANILOVIC J. , VAJTNER Z. , HRANILOVIC R. 
Published: March 2016

AbstractDie Titelverbindung (I) wird elektrochemisch in Hg (elektrolytische Zelle mit Diaphragma; Katholyt :Essigsäure/HCI; Anolyt: verdünnte HCl) stufenweise z den Verbindungen (II)‐(V) reduziert.
ChemInform Abstract: RK.‐VERHALTEN SUBSTITUIERTER CYANESSIGESTER GEGENUEBER 1,1‐DI‐SUBSTITUIERTEN SEMICARBAZIDEN
Authors: NEIDLEIN R. , MENCHE G. 
Published: March 2016

AbstractBeim Erhitzen der Semicarbazide (I) mit den Cyanessigestern (II) bilden sich bei Reaktionstemperaturen von 1 10 ‐ 140°C die substituierten Aminobarbitursäuren (III).
ChemInform Abstract: UMSETZUNGEN VON ISOCYANATEN MIT SCHIFFSCHEN BASEN
Authors: ZOBOVA N. N. , RUSANOV G. N. , ARBUSOV B. A. 
Published: March 2016

AbstractBenzoyl‐ und Trichloracetyl‐isocyanat (I) bilden in Lösungsmitteln wie Äther oder Tetrachlorkohlenstoff mit Schiffschen Basen (II) sowohl 1,3‐Diazetidinone (III) als auch Oxadiazinone (IV).
ChemInform Abstract: HERST. VON TRIAZENEN UND AMINEN DER CARBORAN‐REIHE
Authors: POLYAKOVA L. A. , BILEVICH K. A. , BREGADZE V. I. , OKHLOBYSTIN O. YU. 
Published: March 2016

AbstractAus der Carboranyl‐lithiumverbindung (I) und dem Azid (II) entsteht in Benzol das Triazen (III) (Ausbeute 60‐90%).
ChemInform Abstract: DIE SYNTH. VON O(2),2′‐ANHYDRO‐5,6‐DIHYDRO‐NUCLEOSIDEN
Authors: HALL C. M. , SLOMP G. , MIZSAK S. A. , TAYLOR A. J. 
Published: March 2016

AbstractArabinose (I) liefert mit Cyanamid (II) das Oxazolin (III), das mit den aktivierten Olefinen (IV) über diskutierte Zwischenstufen zu den Nucleosiden (V) führt.
ChemInform Abstract: SYNTH. VON 10ALPHA‐HYDROXY‐PROSTAGLANDINEN
Authors: CRABBE P. , GUZMAN A. , VELARDE E. 
Published: March 2016

AbstractDas J od‐lacton (I) liefert die Hydroxy‐acetate (IIa) und (IIb), die zum Diol (II hydrolysiert werden.
ChemInform Abstract: LEITFAEHIGKEITSAENDERUNGEN PASSIVIERTER DUENNER EISENFILME BEI DER GALVANOSTATISCHEN KATHODISCHEN RED.
Authors: HARUYAMA SHIRO , TSURU TOORU 
Published: March 2016

AbstractBei der kathodischen Reduktion von Passivschichten auf F e in neutraler Borat‐ Borsäure‐Pufferlösung erfolgt ein momentaner Leitfähigkeitsanstieg der Schicht, der der Reduktion überschüssigen Sauerstoffs in der äußeren Oxidschicht zugeschrieben wird.
ChemInform Abstract: ′UNIPARTICULATE′ ELEKTROPHILE ADDITION AN ALKENYLIDENCYCLOPROPANE
Authors: PASTO D. J. , FU TAI CHEN A. , CIURDARU G. , PAQUETTE L. A. 
Published: March 2016

Abstract2‐Phenylisobutenyliden‐cyclopropan (I) liefert mit Chlorsulfonylisocyanat (II) die Addukte (IIIa)‐(VIa) bzw. die Hydrolyseprodukte (IIIb)‐(VIb).
ChemInform Abstract: REDUKTIVE METALLIERUNG UNGESAETTIGTER VERBINDUNGEN, DER EINFLUSS VON ALLYL‐PROTONEN
Authors: SMITH J. G. , WIKMAN R. T. 
Published: March 2016

AbstractDie Umsetzung von trans‐1,2‐Diphenylpropen (I) mit Alkalimetallen liefert in Abhängigkeit von der Art des Metalls, vom Lösungsmittel und von der Temperatur die Produkte (II)‐(V) in verschiedenen Verhältnissen.
ChemInform Abstract: SYNTH. VON THIOHARNSTOFFDERIVATEN 10. MITT. ANALOGA VON N‐METHYL‐PIPERAZINYL‐THIOCARBANILID
Authors: GALSTUKHOVA N. B. , SHCHUKINA M. N. , ZYKOVA T. N. , PERSHIN G. N. , ANTOSH K. 
Published: March 2016

Abstract1‐Methyl‐4‐(p‐aminophenyl)‐piperazin (I) reagiert mit Ammoniumrhodanid und Benzoylchlorid in guter Ausbeute zum N‐Benzoyl‐thioharnstoff (II), der sich mit l0%iger NaOH in 43%iger Ausbeute zum Thioharnstoff (III) verseifen lä‐βt. Umsetzung von (I) mit den Isothiocyanaten (IV) führt in Ausbeuten zwischen 43 und 92% zu den Thiocarbaniliden (V).
ChemInform Abstract: STRUKTUR DER REOXIDATIONSPRODUKTE DES 7,8‐DIHYDRO‐NEOPTERINS
Authors: SUGIURA KATSURA , GOTO MIKI 
Published: March 2016

AbstractDie Produkte der Reduktion von D‐erythro‐Neopterin mit Na2S2O4 oder Fe‐Staub (in wäßriger Essigsäure) gehen in neutraler wäßriger Lösung (unter Lichtausschluß) in Gemische der gelben Verbindungen (I) mit den farblosen Verbindungen (IIa), erythro‐(Ilb) und threo‐(IIb) über.
ChemInform Abstract: FREIE‐RADIKAL‐CHEMIE VON ORGANOPHOSPHOR‐VERBINDUNGEN 3. MITT. ALPHA‐ UND BETA‐SPALTUNG IN RK. VON ALKOXY‐ UND THIYL‐RADIKALEN MIT DREIWERTIGEN ORGANOPHOSPHOR‐DERIVATEN
Authors: BENTRUDE WESLEY G. , HANSEN ERIC R. , KHAN WAJID A. , MIN TAE B. , ROGERS PETER E. 
Published: March 2016

AbstractDas Verhältnis der aus der Titelreaktion erhaltenen Oxidations‐ und Substitutionsprodukte (III) bzw. (IV) wird untersucht, um Faktoren, die diese Reaktionen beeinflussen, zu ermitteln.
ChemInform Abstract: CARBONYLKOMPLEXE VON EISEN, KOBALT UND NICKEL MIT TRIS‐(TRIMETHYLSILYLMETHYL)‐PHOSPHIN
Authors: HSIEH ANDREW T. T. , WILKINSON GEOFFREY 
Published: March 2016

AbstractDas Titelphosphin reagiert mit Fe3(CO) 12 zu (I) und mit Fe2(CO)9 zu dem nur spektroskopisch nachgewiesenen Komplex (II).
ChemInform Abstract: CHIRALE TRICARBONYLCYCLOBUTADIENEISEN‐KOMPLEXE
Authors: GRUBBS R. H. , GREY R. A. 
Published: March 2016

AbstractDie Belichtung des Acetylens (I) und des cyclischen Carbonats (II) in Aceton ergibt das Cycloaddukt (III), das mit der Verbindung (IV) zu dem Komplex (V) reagiert.
Predicting potential distribution of poorly known species with small database: the case of four‐horned antelopeTetracerus quadricornison the Indian subcontinent
Authors: Pokharel Krishna Prasad , Ludwig Tobias , Storch Ilse 
Published: March 2016

AbstractInformation gaps on the distribution of data deficient and rare species such as four‐horned antelope (FHA) in Nepal may impair their conservation. We aimed to empirically predict the distribution ofFHAin Nepal with the help of data from the Indian subcontinent. Additionally, we wanted to identify core areas and gaps within the reported range limits and to assess the degree of isolation of known Nepalese populations from the main distribution areas in India. The tropical part of the Indian subcontinent (65°–90° eastern longitude, 5°–30° northern latitude), that is, the areas south of the Himalayan Mountains. Using MaxEnt and accounting for sampling bias, we developed predictive distribution models from environmental and topographical variables, and known presence locations of the study species in India and Nepal. We address and discuss the use of target group vs. random background. The prediction map reveals a disjunct distribution ofFHAwith core areas in the tropical parts of central to southern–western India. At the scale of the Indian subcontinent, suitableFHAhabitat area in Nepal was small. The Indo‐Gangetic Plain isolates Nepalese from the IndianFHApopulations, but the distribution area extends further south than proposed by the currentIUCNmap. A low to intermediate temperature seasonality as well as low precipitation during the dry and warm season contributed most to the prediction ofFHAdistribution. The predicted distribution maps confirm otherFHArange maps but also indicate that suitable areas exist south of the known range. Results further highlight that small populations in the Nepalese Terai Arc are isolated from the Indian core distribution and therefore might be under high extinction risk.
A class of finite difference schemes for interface problems with an HOC approach
Authors: Mittal H. V. R. , Kalita Jiten C. , Ray Rajendra K. 
Published: March 2016

SummaryIn this paper, we propose a new methodology for numerically solving elliptic and parabolic equations with discontinuous coefficients and singular source terms. This new scheme is obtained by clubbing a recently developed higher‐order compact methodology with special interface treatment for the points just next to the points of discontinuity. The overall order of accuracy of the scheme is at least second. We first formulate the scheme for one‐dimensional (1D) problems, and then extend it directly to two‐dimensional (2D) problems in polar coordinates. In the process, we also perform convergence and related analysis for both the cases. Finally, we show a new direction of implementing the methodology to 2D problems in cartesian coordinates. We then conduct numerous numerical studies on a number of problems, both for 1D and 2D cases, including the flow past circular cylinder governed by the incompressible Navier–Stokes equations. We compare our results with existing numerical and experimental results. In all the cases, our formulation is found to produce better results on coarser grids. For the circular cylinder problem, the scheme used is seen to capture all the flow characteristics including the famous von Kármán vortex street. Copyright © 2016 John Wiley & Sons, Ltd.
Assessment of a lumped coupled flow‐isotope model in data scarce Boreal catchments
Authors: Smith A. , Welch C. , Stadnyk T. 
Published: March 2016

AbstractQuantifying streamflow sources within remote, data scarce, Boreal catchments remains a significant challenge because of limited accessibility and complex, flat topography. The coupled use of hydrometric and isotopic data has previously been shown to facilitate quantification of streamflow sources, but application has generally been limited to small basins and short time scales. A lumped flow‐isotope model was used to estimate contributing streamflow sources (soil, ground, and wetland water) over a four‐year period in two large nested headwater catchments (Sapochi and Odei Rivers) in northern Manitoba, Canada. On average, the primary streamflow source was estimated as soil water (60%) in the Sapochi River, and groundwater (54%) in the Odei River. A strong seasonal influence was observed: soil water was the primary streamflow source in summer, changing to groundwater and wetlands during the winter. Interannual variability in streamflow sources was strongly linked to the presence or absence of late summer rainfall. The greatest uncertainties in source quantification were identified during the spring freshets and high precipitation events, and hence, simulations may be improved through explicit representation of the soil freeze/thaw process and data collection during this period. Assessment of primary streamflow components and qualitative uncertainty estimation using coupled isotope‐flow modelling is an effective method for first‐order identification of streamflow sources in data sparse remote headwaters. Copyright © 2016 John Wiley & Sons, Ltd.
Image‐based quantification of fiber alignment within electrospun tissue engineering scaffolds is related to mechanical anisotropy
Authors: Fee Timothy , Downs Crawford , Eberhardt Alan , Zhou Yong , Berry Joel 
Published: March 2016

AbstractIt is well documented that electrospun tissue engineering scaffolds can be fabricated with variable degrees of fiber alignment to produce scaffolds with anisotropic mechanical properties. Several attempts have been made to quantify the degree of fiber alignment within an electrospun scaffold using image‐based methods. However, these methods are limited by the inability to produce a quantitative measure of alignment that can be used to make comparisons across publications. Therefore, we have developed a new approach to quantifying the alignment present within a scaffold from scanning electron microscopic (SEM) images. The alignment is determined by using the Sobel approximation of the image gradient to determine the distribution of gradient angles with an image. This data was fit to a Von Mises distribution to find the dispersion parameter κ, which was used as a quantitative measure of fiber alignment. We fabricated four groups of electrospun polycaprolactone (PCL) + Gelatin scaffolds with alignments ranging from κ = 1.9 (aligned) to κ = 0.25 (random) and tested our alignment quantification method on these scaffolds. It was found that our alignment quantification method could distinguish between scaffolds of different alignments more accurately than two other published methods. Additionally, the alignment parameter κ was found to be a good predictor the mechanical anisotropy of our electrospun scaffolds. The ability to quantify fiber alignment within and make direct comparisons of scaffold fiber alignment across publications can reduce ambiguity between published results where cells are cultured on “highly aligned” fibrous scaffolds. This could have important implications for characterizing mechanics and cellular behavior on aligned tissue engineering scaffolds. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1680–1686, 2016.
Heat, water and carbon exchanges in the tall megacity of Shanghai: challenges and results
Authors: Ao Xiangyu , Grimmond C. S. B. , Chang Yuanyong , Liu Dongwei , Tang Yuqi , Hu Ping , Wang Yadong , Zou Jun , Tan Jianguo 
Published: March 2016

ABSTRACTThe observed surface energy balance fluxes are essential to improve model forecasting ability but such data are scarce for subtropical cities and urban areas with tall buildings. One year of eddy covariance flux data for an area within Shanghai with a wide range of building heights (8–150 m, mean by direction) are analysed by wind direction. Consideration is given to how to distinguish between local‐ and micro‐scale fluxes. At the local‐scale, median daily peaks of sensible heat flux occur in the early afternoon (winter: 87 W m−2, spring: 205 W m−2, summer: 292 W m−2, autumn: 135 W m−2). The latent heat flux is small in winter (median daily maxima 21 W m−2) and slightly larger in spring, summer and autumn (49, 65, 49 W m−2, respectively). The monthly mean daytime Bowen ratio under all‐sky conditions ranges from 2 to 4.7. At this site, with predominately impervious surface (85% buildings/pavement, 14% vegetation), the enhancement of evaporation following rainfall usually lasts for about 12 h. Consistently larger Bowen ratios at the micro‐scale than the local‐scale are attributed to roughness effects and the impact of extensive areas of dry walls. The daily median CO2 flux is dominated by traffic emissions, with two peaks associated with morning and evening rush hours. The data provide insights into urban surface controls on momentum, energy and carbon dynamics, with implications for urban planning strategies in the context of rapid global urbanization and climate change.
Mesophase features in isotactic poly(propylene‐co‐1‐heptene) copolymers
Authors: García‐Peñas Alberto , Gómez‐Elvira José M , de la Orden María U , Cerrada María L , Pérez Ernesto 
Published: March 2016

AbstractThe influence of crystallization rate on the interesting polymorphism of random isotactic poly(propylene‐co‐1‐heptene) copolymers was studied, with particular attention to the conditions for obtaining the mesomorphic phase. Owing to the important decrease of cooling rate involved as the 1‐heptene content increases, the mesophase can be clearly observed by DSC for co‐unit contents above about 5 mol%. Furthermore, only the mesophase (or the amorphous phase) was found for the copolymer with 13.9 mol% 1‐heptene at common cooling rates of the calorimeter. Additionally, the copolymer with 21.4 mol% co‐units was found to be completely amorphous under any thermal treatment analyzed. Variable‐temperature diffraction experiments were carried out to ascertain unambiguously the nature of the phases involved. Finally, a remarkable transparency was attained (above 80% transmittance in the visible light region) at intermediate and high 1‐heptene contents, using easily accessible cooling rates. © 2016 Society of Chemical Industry
Integrated three‐dimensional fiber/hydrogel biphasic scaffolds for periodontal bone tissue engineering
Authors: Puppi Dario , Migone Chiara , Grassi Lucia , Pirosa Alessandro , Maisetta Giuseppantonio , Batoni Giovanna , Chiellini Federica 
Published: March 2016

AbstractCombining a tissue engineering scaffold made of a load‐bearing polymer with a hydrogel represents a powerful approach to enhancing the functionalities of the resulting biphasic construct, such as its mechanical properties or ability to support cellular colonization. This research activity was aimed at the development of biphasic scaffolds through the combination of an additively manufactured poly(ϵ‐caprolactone) (PCL) fiber construct and a chitosan/poly(γ‐glutamic acid) polyelectrolyte complex hydrogel. By investigating a set of layered structures made of PCL or PCL/hydroxyapatite composite, biphasic scaffold prototypes with good integration of the two phases at the macroscale and microscale were developed. The biphasic constructs were able to absorb cell culture medium up to 10‐fold of their weight, and the combination of the two phases had a significant influence on compressive mechanical properties compared with hydrogel or PCL scaffold alone. In addition, due to the presence of chitosan in the hydrogel phase, biphasic scaffolds exerted a broad‐spectrum antibacterial activity. The developed biphasic systems appear well suited for application in periodontal bone regenerative approaches in which a biodegradable porous structure providing mechanical stability and a hydrogel phase functioning as absorbing depot of endogenous proteins are simultaneously required. © 2016 Society of Chemical Industry
Retrograde double‐labeling demonstrates convergent afferent innervation of the prostate and bladder
Authors: Lee Sanghee , Yang Guang , Xiang William , Bushman Wade 
Published: March 2016

BACKGROUNDProstatic inflammation is a common histologic finding in men with lower urinary tract symptoms (LUTS). It has been postulated that prostatic inflammation could sensitize afferent neurons innervating the bladder and thereby produce changes in voiding behavior. In support of this, we demonstrate an anatomic basis for pelvic cross‐talk involving the prostate and bladder.METHODSRetrograde labeling was performed by an application of a neuro‐tracer Fast Blue (FB) to one side of either the anterior prostate (AP), dorsal lateral prostate (DLP)/ventral prostate (VP), bladder, or seminal vesicle (SV).RESULTSExamination of dorsal root ganglion (DRG) neuron labeling revealed shared afferent innervation of the prostate and bladder at spinal segments of T13, L1, L2, L6, and S1. Dual labeling was performed by an application of FB and 1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethylindocarbocyaine perchlorate (DiI) to the AP and bladder, respectively. We observed double‐labeled DRG neurons at T13, L1, L2, L6, and S1—a finding that proves convergent innervation of prostate and bladder.CONCLUSIONSOur observations demonstrate the potential for neural cross‐talk between the prostate and bladder and support a postulated mechanism that prostatic inflammation may induce hyper‐sensitization of bladder afferents and produce irritative LUTS. Prostate 76:767–775, 2016. © 2016 Wiley Periodicals, Inc.
Metal complexes of diaryltetrabenzodiazaporphyrins
Authors: Andrianov Dmitry S. , Levitskiy Oleg A. , Rybakov Victor B. , Magdesieva Tatiana V. , Cheprakov Andrey V. 
Published: March 2016

AbstractThe metal complexes of a pivotal representative of the so‐called porphyrin‐phthalocyanine hybrid series ‐ 5,15‐diaryl‐10,20‐diazatetrabenzoporphyrin (Ar2TBDAP), ‐ recently made available by a new selective and versatile procedure, with Zn, Ni, Cu, and Pd were synthesized and characterized by single crystal X‐ray analysis, UV‐vis/NIR absorption and emission spectroscopy, nanosecond and microsecond time‐resolved (NSTA and TCSPC) experiments and by means of cyclic voltammetry. The complexes obtained are compared with the related tetrabenzo‐annelated tetrapyrrolic systems, including tetrabenzoporphyrin, phthalocyanine, and other hybrids, using both experimental data and the results of quantum chemical DFT and TD‐DFT computations. The Ar2TBDAP system reported shares sharp hyperchromic long‐wavelength absorption of phthalocyanines with the essential features of extended porphyrins including the possibilities of effective chemical modification through meso‐aryl substituents.
Effect of Tween 20 on the Properties of Stearate Oleogels: an in‐Depth Analysis
Authors: Uvanesh K. , Sagiri Sai S. , Banerjee Indranil , Shaikh Hamid , Pramanik Krishna , Anis Arfat , Pal Kunal 
Published: March 2016

AbstractThis work deals with the investigation of the polymorphic changes associated with stearic acid in the presence of Tween 20 during the formation of oleogels. Tween 20 was utilized as a crystal habit modifier and its effect on the physical and thermal properties of the oleogels have been studied. Tween 20 was found to stabilize the polymorph B of stearic acid, marked by an increase in the leaf‐like structures. Fluorescent recovery after photobleaching studies suggested Tween 20 concentration‐dependent reduction in the mobile fractions. Gelation studies suggested a delay in the induction time of nucleation of stearic acid in the presence of Tween 20 was due to the decrease in the degree of supercooling. Avrami analysis supported the stabilization of the polymorph B of stearic acid in the presence of Tween 20. XRD measurements indicated that Tween 20 promoted the growth of the stearic acid crystals while forming leaf‐like structures. The molecular rearrangement of the gelator network was quicker and ordered in the Tween 20‐containing oleogels. The increase in ordered arrangement of the stearic acid molecules has lowered the crystal imperfections. In other words, it enhanced the crystal gaps (pores) associated with the gelators. When stress (either thermal or mechanical) was introduced, the strength of the oleogels was decreased due to the syneresis of oil through the pores. An increase in the Tween 20 concentration‐dependent relaxation of the oleogels was also observed due to the polymorphic change and arrangement of the gelators.
“RADIOTRANSCRIPTOMICS”: A synergy of imaging and transcriptomics in clinical assessment
Authors: Katrib Amal , Hsu William , Bui Alex , Xing Yi 
Published: March 2016

Recent advances in quantitative imaging and “omics” technology have generated a wealth of mineable biological “big data”. With the push towards a P4 “predictive, preventive, personalized, and participatory” approach to medicine, researchers began integrating complementary tools to further tune existing diagnostic and therapeutic models. The field of radiogenomics has long pioneered such multidisciplinary investigations in neuroscience and oncology, correlating genotypic and phenotypic signatures to study structural and functional changes in relation to altered molecular behavior. Given the innate dynamic nature of complex disorders and the role of environmental and epigenetic factors in pathogenesis, the transcriptome can further elucidate serial modifications undetected at the genome level. We therefore propose “radiotranscriptomics” as a new member of the P4 medicine initiative, combining transcriptome information, including gene expression and isoform variation, and quantitative image annotations.