bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological and medical problems caused by distress of war in patients with type 2 diabetes
Authors: Bobryk M. I. 
Published: October 2024

Nowadays, the population of Ukraine is under the influence of many stressful factors. Anxiety disorders and a general decline in the quality of life were present even before the start of a full-scale war, as a result of the Covid-19 pandemic. The full-scale war contributed to the continuation and intensification of chronic stress, deepening depression, and anxious expectations among various categories of the population of Ukraine, not only due to the immediate danger to life, changes of residence, insomnia, staying in shelters, but also due to the uncertainty of the future. The prevalence of depression, post-traumatic stress disorder (PTSD), and their complications among the population of Ukraine, both within the country and among those who have left it as refugees, reaches 30 %. PTSD often overlaps with an additional anxiety disorder, alcohol abuse, depression, and psychosomatic disorders. To reduce complications from PTSD, early diagnosis, optimally carried out at the primary care level, is recommended. All categories of the population that have experienced a traumatic situation, including both military and civilians, are subject to examination. Leptin and ghrelin were studied to assess hormonal changes during major depressive disorder. The levels of these hormones are related to the body’s energy homeostasis. Chronic stress reduces leptin levels in blood serum. In addition, it has also been shown that the administration of leptin to animals can cause an antidepressant effect, which is accompanied by an increased expression of brain-derived neurotrophic factor in the hippocampus. Depression and anxiety are common comorbid conditions in patients with type 2 diabetes mellitus. Taking into consideration the proven bidirectional relationship between depression and diabetes, it is necessary to address both conditions effectively.
Objective — assessment of the severity of depression in patients with T2DM with respect to their vitamin D status under conditions of chronic stress.
Materials and methods. 133 patients with T2DM aged 19 — 75 were examined. Vitamin D status was assessed using the chemiluminescent immunoassay (CLIA) method. Depression was assessed using the DASS 21 questionnaire.
Results. A significant inverse relationship between the level of vitamin D and the severity of depression was found.
Conclusions. During the war in Ukraine, an increase in psychopathological disorders among the population has been observed. There is an evidence base indicating the negative impact of depression on the course of diabetes. Given the steady rise in cases of type 2 diabetes and psychopathological disorders in the Ukrainian population, it is necessary to implement measures to correct both carbohydrate metabolism and the psychological condition of patients. Our study demonstrated a statistically significant inverse correlation between the level of depression and the concentration of 25-hydroxycalciferol in patients with type 2 diabetes who are exposed to chronic stress.
Domestic researchers who have made important contributions to the study of digestive system diseases: images in art. Nina Fedorivna Deyneko
Authors: Gubergrits N. B. , Byelyayeva N. V. , Linevska K. Y. 
Published: October 2024

Nina Fedorivna Deyneko is a Doctor of Medical Sciences, Professor, an honored worker of science and technology of Ukraine, an outstanding health care worker, a labor veteran, and an academician of the International Academy of Sciences in apiphytotherapy and beekeeping. Under Prof. N. F. Deyneko’s supervision, 86 clinical residents, including 34 foreign ones, and postgraduate students were taught during her tenure at the Kharkiv departments of therapy and gastroenterology. Additionally, 25 candidate dissertations and one doctorate thesis were defended. She served as the head of the Kharkiv Medical Institute’s state examination commission for 15 years, founded and presided over the Kharkiv Medical Society of Gastroenterologists for 20 years, was a member of the All‑Union Society of Gastroenterologists’ Presidium of the Board for more than 20 years, and worked as the deputy chairman of the board of the Ukrainian Republican Society of Gastroenterologists. More than 200 research publications, four monographs, textbooks, and copyright certificates have been produced by Nina Fedorivna. Kharkiv Railway Clinical Hospital №1 became the clinical base of the Department of Gastroenterology of the Ukrainian Institute for Advanced Medical Studies, which was headed by Professor Nina Fedorivna Deyneko. Contemporary diagnostic equipment made it possible to perform diagnosis and treatment of patients with pathologies of the gastrointestinal, liver, biliary and pancreatic pathologies. The goal of methodological and pedagogical work was to optimize the educational process by using modern techniques for tracking students’ practical skills and initial, intermediate, and final levels of learning. Four‑ and three‑ month specialty cycles, as well as pre‑certification and theme improvement in the field of gastroenterology, were implemented during the first five years of the department’s existence. In addition to receiving 20 copyright certificates and publishing over 300 research papers, department staff members have also developed 62 rationalization recommendations that have been put into practice in the healthcare industry. The staff of the department participated in many scientific forums, including those conducted abroad.
Protozoan intestinal invasions in military personnel of the Northern region of Ukraine
Authors: Kyrychenko I. I. , Biriukov M. S. , Pokhil S. I. , Tymchenko O. M. 
Published: October 2024

Objective — to study the prevalence and spectrum of intestinal parasitic infestations (IPI) agents in groups of military personnel of the Northern region of Ukraine, which differed according to the criteria of having symptoms of gastrointestinal disorders and passing the serving in a combat zone.
Materials and methods. From February to November 2023, the study covered 302 servicemen during inpatient medical care at the Military Medical Clinical Center of the Northern Region of Ukraine. Detection and identification of intestinal parasites in samples of feces (SF) was carried out by classical methods of microscopy using the enrichment procedure (formalin‑ethyl acetate sedimentation) and the preparation (from each enriched sediment) of four smears: two thick wet with 50% aqueous solution of glycerol and D’ Anthony iodine solution; two thin, fixed, permanently stained with Whitley’s modified trichrome (mWT) or Heidenhain’s iron hematoxylin (HIH) and the modified Ziehl‑Neelsen acid method (mZN). Smear microscopy results were evaluated according to the criteria of the US Clinical and Laboratory Standards Institute.
Results. It was established that the level of prevalence of IPI among the examined servicemen reached 10.6% with variation in the value of this indicator in different groups of soldiers from 2.2% to 12.6%. A specific share of protozoan monoinvasions in soldiers reached 65.6%, and mixed invasions (with two parasites at the same time) — 34.4%. Soldiers with symptoms of gastrointestinal diseases had significantly higher rates of IPI than did asymptomatic. In addition, the infestation rates among soldiers were higher in the cold season (October‑February) with a seasonality index of 1.9. All cases of IPI in servicemen (n=32) were caused by protozoan parasites (n=39), in the etiological spectrum of which the vast majority (84.6%) were pathogenic species (Blastocystis sp., Dientamoeba fragilis, Giardia lamblia), and a smaller proportion (15.4%) were commensal species (Chilomastix mesnili, Iodamoeba butschliі). Among pathogenic protozoa (n=33), Blastocystis sp. (51.5%) and D. fragilis had the highest proportion (42.4%), G. lamblia (6.1%) had significantly less one.
Conclusions. Optimizing the management tactics of military medicine to reduce the negative impact of IPI on the health and combat capacity of servicemen requires knowledge about the prevalence and spectrum of pathogens of invasions among specific groups of soldiers. A necessary condition for increasing the efficiency of microscopic detection/identification of protozoan parasites (primarily D. fragilis) in the SF is the production of permanently stained (mWT or HIH) smears. Microscopic examination of such smears at high resolution (100ґ objective, oil immersion) provides an increased incidence of detection/identification of Blastocystis sp. by 47.1% and D. fragilis by 100%.
Determination of asprosin levels and analysis of correlative relationships with carbohydrate metabolism indicators in patients with type 2 diabetes and chronic pancreatitis
Authors: Zhuravlyova L. V. , Markevych M. A. 
Published: October 2024

Objective — to investigate asprosin levels in patients with type 2 diabetes mellitus (DM) and chronic pancreatitis (CP) and to analyze the correlations between asprosin levels and carbohydrate metabolism indicators in these patients.
Materials and methods. The study was conducted on 100 patients treated at the Kharkiv Regional Clinical Hospital from 2020 to 2022. Patients were divided into two groups. The first group (n=30) included patients with type 2 DM, and the second group (n=70) comprised patients with comorbid type 2 DM and CP. The control group consisted of 20 healthy persons of comparable age. Diagnoses of CP and type 2 DM were established according to the approved protocols of the Ministry of Health of Ukraine. Asprosin levels in the blood were determined using enzyme‑linked immunosorbent assay (ELISA). Fasting blood glucose and insulin concentrations were studied, and the HOMA‑IR index was calculated.
Results. The obtained results showed statistically significant differences in the level of asprosin between the groups of patients and the control group. Patients with comorbid type 2 DM and CP had significantly higher asprosin levels (10.06±3.56 ng/ml) compared to those with type 2 DM alone (7.34±2.08 ng/ml) and the control group (2.81±1.34 ng/ml). Correlation analysis revealed moderate positive correlations between asprosin and insulin levels (r=0.41) and HOMA index (r=0.47) in patients with type 2 DM without CP. In patients with comorbid type 2 DM and CP, moderate correlations were observed between asprosin levels and insulin (r=0.52) and HOMA index (r=0.53).
Conclusions. Asprosin is an important adipokine that influences the development of insulin resistance and inflammatory processes in type 2 DM and CP. The highest asprosin levels were observed in the group with comorbid type 2 DM and CP. Moderate positive correlations were established between asprosin levels and insulin levels, as well as the HOMA‑IR index in patients from both groups. This suggests asprosin as a potential target for therapeutic intervention in type 2 DM and its complications.
Effectiveness and safety of gut microbiota modification in intestinal diseases. Review
Authors: Tkach S. M. , Kharchenko N. V. , Dorofeyev A. E. 
Published: October 2024

The gut microbiota (GM) is a complex and dynamic community of microorganisms that colonize the human gastrointestinal tract and play an important role in various aspects of the host’s physiology and health. GM is involved in digestion and assimilation of nutrients, synthesis of vitamins and metabolites, modulation of the immune system and defense against pathogens. However, the gut microbiota can also be a source of inflammation and disease when its composition and function are altered. This phenomenon, known as dysbiosis, is associated with almost all gastrointestinal diseases and is most prominent in inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), colorectal cancer, and celiac disease. Considering the important role of GM in the pathogenesis of IBD and other diseases of the gastrointestinal tract, several methods of its modification have been proposed, including the use of probiotics, prebiotics, synbiotics, antibiotics, dietary interventions, fecal microbiota transplantation (FTM) and bacteriophage therapy. However, drawing general conclusions about the efficacy and safety of these approaches is often difficult due to variability in interventions, doses, timing of administration, and the inevitable heterogeneity of host microbiome profiles and gut status. This review presents the results of a large international survey, purposed on the assessment of current practice, preferences, challenges, and expectations of doctors regarding the assessment of the composition of GM and the use of antibiotics, probiotics and TFM in intestinal diseases. The survey was also aimed on the identification of factors influencing the decision‑making process by doctors and barriers limiting the implementation of GM modification in clinical practice. Conclusions drawn from the results of the survey highlight the need for further research, standardization of techniques and evidence‑based recommendations to optimize the use of probiotics, antibiotics and TFM in clinical practice.
Exploring the Potential of Nigerian Clay-Based Pozzolans for Enhancing Concrete Performance and Sustainability: A Study on Strength, Hydration, and Durability
Authors: Adegbemileke Samuel Adesina , Osuji Sylvester Obinna , Ogirigbo Okiemute Roland 
Published: October 2024

This study investigated the potential of calcined clays from Nigerian deposits in the production of ternary blends of cement. Clay samples were obtained from three different locations namely: Ikpeshi, Okpilla and Uzebba. The raw clay samples were then calcined at 700°C and 800°C. Chemical and mineralogical compositions were determined for the raw and calcined clay samples using XRF and XRD respectively. The chemical composition confirmed these clays as potential pozzolans with SiO2, Al2O3, and Fe2O3 collectively exceeding 70%. XRD analysis identified kaolinite and quartz as major mineral phases in the raw clays, which transformed into metakaolin upon calcination. Compressive strength tests on mortar samples prepared with 50% substitution of Portland cement with the calcined clay and limestone, showed that Ikpeshi clay at 800°C had the best strength performance, with a strength activity index of 0.92 at 28 days, demonstrating superior pozzolanic potential. Strength development was more significant between 7 and 28 days, indicating the pozzolanic reaction's contribution to long-term strength. However, the initial strength at 3 days was lower than the reference cement due to a delayed pozzolanic reaction. XRD analysis of blended pastes revealed typical hydration phases like portlandite, C-S-H, Strätlingite, and ettringite, with the ternary blends showing reduced portlandite content, indicating absorption by the pozzolan's alumina phase. Durability assessments revealed that the ternary blends exhibited improved resistance to water and chloride ion ingress. These findings highlight the effectiveness of Nigerian calcined clays in producing durable and sustainable concrete, supporting their use as supplementary cementitious materials to reduce the environmental impact of concrete production.
Coming out: Impact on friendships between heterosexual men and gay, bisexual, and other men who have sex with men
Authors: Oueis Jeremy , McKie Raymond M. , Copeland Erika , Johnston Samantha F. , Reissing Elke D. 
Published: October 2024

Friendships between heterosexual men and gay, bisexual, and other men who have sex with men (gbMSM) appear to be less common than other friendship dyads. While some heterosexual men’s fear of being perceived as gay may act as a barrier in forming these friendships, research conducted within the past decade suggests that attitudes toward gbMSM are improving in Western cultures. Little is known regarding how heterosexual men react to their peers who are gbMSM after disclosing their sexual orientations to them during this cultural shift in North America. Using inclusive masculinity theory as a framework, the purpose was to examine how friendships between heterosexual men and gbMSM are impacted following their coming out experiences. Data were collected from heterosexual men and gbMSM aged 18–36 ( M = 28.52) residing in the United States and Canada ( N = 443) through Amazon Mechanical Turk. Heterosexual and gbMSM were asked to answer open-ended questions regarding the gbMSM’s coming out experiences and describe changes in their friendships afterward. Thematic analysis guidelines were followed to analyze the responses. Results indicated three pathways for friendships: a positive coming-out experience with an improved friendship, a neutral coming-out experience with no change in the friendship, and a negative experience followed by a damaged or terminated friendship. Findings suggest that positive attitudes toward cross-orientation friendships may be more prevalent and accepted at present than historically. These findings start an important dialogue with the potential implication of further normalizing positive friendships between heterosexual men and gbMSM.
Past and Present of the Vietnam Problem
Authors: Vasiljev Ivo 
Published: October 2024

The direct military intervention of the USA in Vietnam and the bombing of the GDR by the American air force caused the Vietnamese issue to become a world issue again. The Council of Governments is interested in its early resolution and a significant part of public opinion in the world. To the forefront of the common interest aims to restore peace in this part of the world, so that further bloodshed and the spread of war to other countries and parts of the world are prevented. Solutions however, can only be built on such a basis that is acceptable for the Vietnamese nation. A solution that is not acceptable to the Vietnamese nation can only lead to a prolongation or even to the spread of the war, because the Vietnamese after twenty-five years of fighting for independence, they are determined to fight for real independence and they have enough experience, certain strengths and friends to do that. Though the Vietnamese question became a world problem, it still remains primarily a Vietnamese one, a problem that can only be solved in accordance with the authorized national thoughts and political realities of this country.
PERANCANGAN ALAT UKUR SISTEM MONITORING TERHADAP SUHU DAN KELEMBABAN TANAH BERBASIS IOT (INTERNET OF THINGS) DENGAN MENGGUNAKAN WEB MOBILE DI DESA MUARA KATI KABUPATEN MUSI RAWAS
Authors: Sobri Ahmad , Nurdiansyah Deni , Sunardi Lukman 
Published: October 2024

Tujuan penelitian ini untuk mengetahui tingkat kadar suhu dan kelembaban tanah yang terdapat desa Muara Kati Kabupaten Musi Rawas. Dalam penggunaan alat pengukur suhu ph dan kelembaban tanah akan berdampak pada hasil tanaman petani yang ada di wilayah kecamatan muara kati dan juga akan mengembangkan masyarakat dalam bercocok tanaman perkebunan yang lain apabila dampak tanha yang baik. Alat ukur yang digunakan yaitu arduino uno, kabel usb, arduino IDE, Ethernet Shield, Kabel Twisted Pai, dan sistem rancangan webmobile yang menggunakan UML, PHP dan Mysql yang memanbantu sistem ini. untuk membuat rancangan sementara pada sistem yang akan dibuat yaitu use case, activity diagram, sequence diagram dan juga class diagram.Sistem ini juga menampilkan halaman yang akan mendeteksi alur dari senor yang ada pada hardware dan akan menampilkan tingkat keasaman tanah pada pH tanah serta suhu yang labil dalam pengelolaan tanah dan juga kadar air yang baik pada tanah yang disebabkan oleh kelembaban yang labil.
ANALISIS PENINGKATAN KUALITAS LAYANAN E-LEARNING PALCOMTECH MENGGUNAKAN PENDEKATAN WEBQUAL 4.0 DAN E-LEARNING MATURITY MODEL(EMM)
Authors: Maria Fitri , Herdiansyah M. Izman , Sutabri Tata , Kunang Yesi Novaria 
Published: October 2024

E-Learning merupakan satu metode pembelajaran yang sangat penting,terutama dalam konteks lembaga kursus dan pelatihan (LKP) seperti PalComTech. Penelitian akan dilakukan untuk menganalisis peningkatan kualitas sistem e-learning LKP PalComTech menggunakan pendekatan Webqual 4.0. dan E-learning Maturity Model (eMM).Dengan demikian tujuan utama tesis ini adalah:Menganalisis Kualitas Layanan e-Learning: Melakukan evaluasi mendalam terhadap berbagai aspek kualitas layanan e-learning yang disediakan oleh LKP PalComTech, termasuk konten, kegunaan, interaktivitas, dan keandalanAbstrak harus jelas, deskriptif dan harus memberikan gambaran singkat masalah yang diteliti. Menerapkan pendekatan Webqual 4.0 untuk melakukan analisis kualitas layanan e-learning,sehingga memberikan pemahaman yang komprenshif tentang kinerja platform e-learning.Memberikan rekomendasi konkret untuk perbaikan dan pengembangan platform e-learning LKP PalComTech.
ETHNOCULTURAL PRACTICES AND TRADITIONS OF CIVIC AND PATRIOTIC EDUCATION IN THE NORTH CAUCASUS
Authors: Ivanova Svetlana Yu. 
Published: October 2024

The article examines the techniques and technologies employed in the indoctrination of the patriotic civic idea in modern Russian society with the objective of strengthening and spreading it. The paper identifies and examines the positive social and cultural practices that contribute to the formation of patriotism in the multiethnic environment of the North Caucasus. It considers the potential for these practices to be scaled up on a national level. The authors conceptualize patriotism as a phenomenon of public relation, examining its regional manifestations and their relationship with ethno-cultural, ethno-political, historical and cultural properties of regional communities. The article also presents the results of a discourse analysis of the idea of patriotism in scientific papers published in the subjects of the Russian Federation in the North Caucasus with an emphasis on the resource of ethnopedagogy. The authors conclude that in this context patriotism is closely connected with ethno-patriotism based on the historical past, on the heroization of mythological characters of the peoples of the North Caucasus. The formation of patriotism is facilitated by the involvement of pupils in folk art and military-patriotic education. Furthermore, expert opinions confirm the existence of a significant resource for the formation of patriotism in the ethno-cultural heritage of the peoples of the North Caucasus.