bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pim-1L Protects Cell Surface–Resident ABCA1 From Lysosomal Degradation in Hepatocytes and Thereby Regulates Plasma High-Density Lipoprotein Level
Authors: Katsube Akira , Hayashi Hisamitsu , Kusuhara Hiroyuki 
Published: October 2016

Objective—
ATP-binding cassette transporter A1 (ABCA1) exerts an atheroprotective action through the biogenesis of high-density lipoprotein in hepatocytes and prevents the formation of foam cells from macrophages. Controlling ABCA1 is a rational approach to improving atherosclerotic cardiovascular disease. Although much is known about the regulatory mechanism of ABCA1 synthesis, the molecular mechanism underpinning its degradation remains to be clearly described.

Approach and Results—

ABCA1 possesses potential sites of phosphorylation by serine/threonine-protein kinase Pim-1 (Pim-1). Pim-1 depletion decreased the expression of cell surface–resident ABCA1 (csABCA1) and apolipoprotein A-I–mediated [
3
H]cholesterol efflux in the human hepatoma cell line HepG2, but not in peritoneal macrophages from mice. In vitro kinase assay, immunoprecipitation, and immunocytochemistry suggested phosphorylation of csABCA1 by the long form of Pim-1 (Pim-1L). Cell surface biotinylation indicated that Pim-1L inhibited lysosomal degradation of csABCA1 involving the liver X receptor β, which interacts with csABCA1 and thereby protects it from ubiquitination and subsequent lysosomal degradation. Cell surface coimmunoprecipitation with COS-1 cells expressing extracellularly hemagglutinin-tagged ABCA1 showed that Pim-1L–mediated phosphorylation of csABCA1 facilitated the interaction between csABCA1 and liver X receptor β and thereby stabilized the csABCA1–Pim-1L complex. Mice deficient in Pim-1 kinase activity showed lower expression of ABCA1 in liver plasma membranes and lower plasma high-density lipoprotein levels than control mice.

Conclusions—
Pim-1L protects hepatic csABCA1 from lysosomal degradation by facilitating the physical interaction between csABCA1 and liver X receptor β and subsequent stabilization of the csABCA1–Pim-1L complex and thereby regulates the circulating level of high-density lipoprotein. Our findings may aid the development of high-density lipoprotein–targeted therapy.
Nationalism, Justice and Taxation in an Ottoman Urban Context during the Tanzimat: The Gazino-Club in Manastır
Authors: Vakali Anna 
Published: October 2016

This article elaborates on the history of a Greek club, the gazino, founded in Manastır during the 1850s. It dwells upon the gazino’s interaction with the city’s Christian population regarding the Tanzimat reforms and the expectations these raised among ordinary people for social justice. Such expectations contributed to the emergence of new forms of political negotiation with the Ottoman authorities, in which the gazinists played a decisive role. Furthermore, this article follows the trial of the gazinists in the Tanzimat courts, after being charged with fesat (sedition) and inciting their coreligionists. Based on the trial’s interrogation protocols (istintakname), it is argued that before the Ottoman authorities the gazinists also negotiated and even camouflaged their ideas – pertaining to nationalism, but also to education and morality – by wrapping them up in discourses of progress and modernization favoured by the Tanzimat bureaucracy.
Modeling of the Denebulization of Warm Fogs by Hygroscopic Seeding: Effect of Various Operating Conditions and of the Turbulence Intensity
Authors: Reuge N. , Fede P. , Berthoumieu J.-F. , Foucoin F. , Simonin O. 
Published: October 2016

AbstractThis study addresses the modeling of the denebulization (i.e., the removal of droplets) of warm fogs (T ≥ 0°C) by hygroscopic salt microparticles from the initial seeding at the top of the fog layer to the fall of the rain droplets on the ground. Two main phenomena can occur: condensation of water vapor on salted droplets and the concomitant evaporation of fog droplets, and coalescence between the salted droplets and the fog droplets. Three salts have been investigated: NaCl, CaCl2, and KCl. Based on the conservation equations, the modeling approach (1D) considers the hygroscopicity of the salts through the water activity in the aqueous solution and the coalescence induced by gravity and turbulence. From this study, NaCl is the most efficient salt in the tested operating conditions. Actually, this result can be explained by the strong hygroscopicity of this salt in very dilute solutions. From the calculations, 15 kg of NaCl particles of 6.7-μm diameter can dissipate a typical fog layer of 40 m in height within less than 17 min over 0.25 km2. According to the calculations, a fog layer of 100 m in height can be denebulized within 45 min. The contribution of the coalescence induced by gravity and by turbulence seems to have a negligible effect on the final horizontal visibility, the condensation/evaporation phenomena being preponderant for these operating conditions.
A Numerical Study of Outer Rainband Formation in a Sheared Tropical Cyclone
Authors: Li Qingqing , Wang Yuqing , Duan Yihong 
Published: October 2016

Abstract
The dynamical process of outer rainband formation in a sheared tropical cyclone (TC) is examined in this study using the fully compressible, nonhydrostatic TC model. After the easterly vertical wind shear of 10 m s−1 was imposed upon an intensifying strong TC, an outer rainband characterized by a wavenumber-1 structure formed as a typical principal rainband downshear. Further analysis indicates that the outer rainband formation was closely connected to the activity of the inner rainband previously formed downshear. Moving radially outward, the inner rainband tended to be filamented owing to the strong radial gradient of angular velocity. As the inner rainband approached the outer boundary of the inner core, convection in its middle and upwind segments reinvigorated and nascent convective cells formed upwind of the rainband, caused mainly by the decreased filamentation and stabilization. Subsequently, the rainband reorganized into a typical outer rainband. Three different scenarios are found to be responsible for the outer rainband formation from downshear inner rainbands. The first is the outer rainband forming from an inner rainband downshear as a sheared vortex Rossby wave. The second is the outer rainband forming directly from a single deformation-induced inner rainband. The third is the outer rainband developing from an inner rainband downshear organized from a blend–merger of inner rainbands that were initiated from locally deformed convection upshear right.
Offshore Transport of Shelf Water by Deep-Ocean Eddies
Authors: Cherian Deepak A. , Brink K. H. 
Published: October 2016

AbstractAt continental margins, energetic deep-ocean eddies can transport shelf water offshore in filaments that wrap around the eddy. One example is that of Gulf Stream warm-core rings interacting with the Mid-Atlantic Bight shelf. The rate at which shelf water is exported in these filaments is a major unknown in regional budgets of volume, heat, and salt. This unknown transport is constrained using a series of idealized primitive equation numerical experiments wherein a surface-intensified anticyclonic eddy interacts with idealized shelf–slope topography. There is no shelfbreak front in these experiments, and shelf water is tracked using a passive tracer. When anticyclones interact with shelf–slope topography, they suffer apparent intrusions of shelf–slope water, resulting in a subsurface maximum in offshore transport. The simulations help construct an approximate model for the filament of exported water that originates inshore of any given isobath. This model is then used to derive an expression for the total volume of shelf–slope water transported by the eddy across that isobath. The transport scales with water depth, radius, and azimuthal velocity scale of the eddy. The resulting expression can be used with satellite-derived eddy properties to estimate approximate real-world transports ignoring the presence of a shelfbreak front. The expression assumes that the eddy’s edge is at the shelf break, a condition not always satisfied by real eddies.
Identifying Key Elements to Inform the Development of an HIV Health Behavior Maintenance Intervention
Authors: Hile Stephen J. , Feldman Matthew B. , Raker Amanda R. , Irvine Mary K. 
Published: October 2016

Purpose: To collect information that will inform the development of an intervention to support the maintenance of HIV-related health-promoting behaviors. Design: Focused, in-depth individual and group interviews. Setting: The New York City (NYC) Department of Health and Mental Hygiene (DOHMH) and DOHMH-funded community-based organizations that primarily serve low-income people living with HIV within the five boroughs of NYC. Participants: A total of 42 individuals who had participated in The Positive Life Workshop—an HIV self-management intervention adapted and implemented by the NYC DOHMH. Method: Purposive sampling was used to recruit study participants. Five 60- to 90-minute focus groups (n = 38) and 4 individual interviews were conducted to assess motivations for and barriers to maintaining HIV-related health-promoting behaviors and to elicit feedback on the content and format for the proposed maintenance intervention. Thematic analysis was used to summarize the data. Results: Participants reported that relationships with family, a responsibility to protect others from HIV, and faith/spirituality supported the maintenance of health-promoting behaviors. Barriers to behavior maintenance included substance use and mental health issues. Meeting in small groups was also highlighted as a motivator to sustaining health behaviors, particularly in decreasing isolation and receiving affirmation from others. Conclusion: Participants identified several factors that could be incorporated into an intervention to support HIV-related health-promoting behavior maintenance that could supplement existing HIV self-management interventions.
TGF-β inhibitors stimulate red blood cell production by enhancing self-renewal of BFU-E erythroid progenitors
Authors: Gao Xiaofei , Lee Hsiang-Ying , da Rocha Edroaldo Lummertz , Zhang Cheng , Lu Yi-Fen , Li Dandan , Feng Yuxiong , Ezike Jideofor , Elmes Russell R. , Barrasa M. Inmaculada , Cahan Patrick , Li Hu , Daley George Q. , Lodish Harvey F. 
Published: October 2016

Key Points
The type III TGF-β receptor is a marker that distinguishes “early” and “late” BFU-Es. TGF-β inhibitors increase early BFU-E cell self-renewal and total erythroblast production.
Collective bargaining systems and macroeconomic and microeconomic flexibility: the quest for appropriate institutional forms in advanced economies
Authors: Addison John T. 
Published: October 2016

Abstract
This paper addresses the design of the machinery of collective bargaining from the perspective of microeconomic and macroeconomic flexibility. In the former context, somewhat greater attention is given over to enterprise flexibility than external adjustment. In the latter context, close attention is also paid to changes in collective bargaining along the dimensions of bargaining coverage, structure, and coordination. Support is adduced for the German, contemporary Scandinavian, and British models. The role of trust in securing micro and macro flexibility also receives attention, suggesting that the polder or Dutch model might also be expected to populate the firmament of fit-for-purpose collective bargaining arrangements.

JEL Classification: Microeconomics/Institutions (D02), Institutions and the Macroeconomy (E02), Employment/Unemployment/Wages (E24), Income Distribution (E25), Macroeconomic Policy Objectives (E61), Labor Economics Policies (JO8) Trades Unions (J51), Collective Bargaining (J52), Labor-Management Relations (J53), Public Policy (J58), Comparative Analysis of Economic Systems (P51)
Evaluation of immunologic response of salivary sIg-A in pediatric tuberculosis patients to antigen Ag38-rec of Mycobacterium tuberculosis Indonesian strain
Authors: Raras Tri Yudani Mardining , Pritta Santi Diah Erma , Kusuma HMS Chandra 
Published: October 2016

Objective: We studied the immune response of salivary secretory immunoglobulin A (sIg-A) from a pediatric tuberculosis (TB) group (scoring ≥6) and non-TB group (scoring <6) against recombinant Ag38 (Ag38-rec) fromMycobacterium tuberculosis Indonesian strain.Materials and Methods: Seventy-eight children were divided into three groups; those with TB (n=26), those with suspected TB (n=26), and healthy children (n=26), their saliva was collected, and salivary sIg-A was challenged with purified Ag38-rec using the dot blot method. A change of color from white to dark blue indicated a positive reaction.Results: The immune response of sIg-A of children with TB and those with suspected TB to Ag38-rec was not significantly different. In the TB group, Ag38-rec showed a higher sensitivity than protein purified derivative (PPD) (70.8% vs. 62.5%), but a lower specificity (26.9% vs. 34.62%). However, within both groups (scoring ≥6) as well as non-TB group (scoring <6) Ag38-rec was able to identify children with a positive TST (tuberculin skin test) better than PPD.Conclusion: The antigen Ag38-rec could not distinguish between children with TB (scores ≥6 and <6). However, it demonstrated the potential of Ag38-rec for use in screening for TB infection among children with suspect TB (scores <6).
The Role of Adrenomedullin in Cardiovascular Response to Exercise – A Review
Authors: Krzeminski Krzysztof 
Published: October 2016

AbstractAdrenomedullin (ADM), the product of the vascular endothelial and smooth muscle cells, and cardiomyocytes, is considered to be a local factor controlling vascular tone, cardiac contractility and renal sodium excretion. The aim of this article was to review the existing data on the effect of different types of exercise on plasma ADM concentration in healthy men. The results of studies on the effect of dynamic exercise on the plasma ADM are contradictory. Some authors reported an increase in plasma ADM, while others showed a slight decrease or did not observe any changes. The inverse relationship between plasma ADM and mean blood pressure observed during maximal exercise support the concept that ADM might blunt the exercise-induced systemic blood pressure increase. Positive relationships between increases in plasma ADM and those in noradrenaline, atrial natriuretic peptide (ANP) or interleukin-6 observed during prolonged exercise suggest that the sympathetic nervous system and cytokine induction may be involved in ADM release. Increased secretion of ADM and ANP during this type of exercise may be a compensatory mechanism attenuating elevation of blood pressure and preventing deterioration of cardiac function. Studies performed during static exercise have showed an increase in plasma ADM only in older healthy men. Positive correlations between increases in plasma ADM and those in noradrenaline and endothelin-1 may indicate the interaction of these hormones in shaping the cardiovascular response to static exercise. Inverse relationships between exercise-induced changes in plasma ADM and those in cardiovascular indices may be at least partly associated with inotropic action of ADM on the heart. Interactions of ADM with vasoactive peptides, catecholamines and hemodynamic factors demonstrate the potential involvement of this peptide in the regulation of blood pressure and myocardial contractility during exercise.
Role of Vertical Jumps and Anthropometric Variables in Maximal Kicking Ball Velocities in Elite Soccer Players
Authors: Rodríguez-Lorenzo Lois , Fernandez-del-Olmo Miguel , Sanchez-Molina José Andrés , Martín-Acero Rafael 
Published: October 2016

Abstract
Kicking is one of the most important skills in soccer and the ability to achieve ma ximal kicking velocity with both legs leads to an advantage for the soccer player. This study examined the relationship be tween kicking ball velocity with both legs using anthropometric measurements and vertical jumps (a squat jump (SJ); a countermovement jump without (CMJ) and with the arm swing (CMJA) and a reactive jump (RJ)). Anthropome tric measurements did not correlate with kicking ball velocity. Vertical jumps correlated significantly with kicking ball velocity using the dominant leg only (r = .47, r = .58, r = .44, r = .51, for SJ, CMJ, CMJA and RJ, respectively) . Maximal kicking velocity with the dominant leg was significantly higher than with the non-dominant leg (t = 18.0 4, p < 0.001). Our results suggest that vertical jumps may be an optimal test to assess neuromuscular skills involved in kicking at maximal speed. Lack of the relationship between vertical jumps and kicking velocity with the non-dominant leg may reflect a difficulty to exhibit the neuromuscular skills during dominant leg kicking.
Real time flood forecasting in the Upper Danube basin
Authors: Nester Thomas , Komma Jürgen , Blöschl Günter 
Published: October 2016

Abstract
This paper reports on experience with developing the flood forecasting model for the Upper Danube basin and its operational use since 2006. The model system consists of hydrological and hydrodynamic components, and involves precipitation forecasts. The model parameters were estimated based on the dominant processes concept. Runoff data are assimilated in real time to update modelled soil moisture. An analysis of the model performance indicates 88% of the snow cover in the basin to be modelled correctly on more than 80% of the days. Runoff forecasting errors decrease with catchment area and increase with forecast lead time. The forecast ensemble spread is shown to be a meaningful indicator of the forecast uncertainty. During the 2013 flood, there was a tendency for the precipitation forecasts to underestimate event precipitation and for the runoff model to overestimate runoff generation which resulted in, overall, rather accurate runoff forecasts. It is suggested that the human forecaster plays an essential role in interpreting the model results and, if needed, adjusting them before issuing the forecasts to the general public.
Projected changes of rainfall event characteristics for the Czech Republic
Authors: Svoboda Vojtěch , Hanel Martin , Máca Petr , Kyselý Jan 
Published: October 2016

AbstractProjected changes of warm season (May–September) rainfall events in an ensemble of 30 regional climate model (RCM) simulations are assessed for the Czech Republic. Individual rainfall events are identified using the concept of minimum inter-event time and only heavy events are considered. The changes of rainfall event characteristics are evaluated between the control (1981–2000) and two scenario (2020–2049 and 2070–2099) periods. Despite a consistent decrease in the number of heavy rainfall events, there is a large uncertainty in projected changes in seasonal precipitation total due to heavy events. Most considered characteristics (rainfall event depth, mean rainfall rate, maximum 60-min rainfall intensity and indicators of rainfall event erosivity) are projected to increase and larger increases appear for more extreme values. Only rainfall event duration slightly decreases in the more distant scenario period according to the RCM simulations. As a consequence, the number of less extreme heavy rainfall events as well as the number of long events decreases in majority of the RCM simulations. Changes in most event characteristics (and especially in characteristics related to the rainfall intensity) depend on changes in radiative forcing and temperature for the future periods. Only changes in the number of events and seasonal total due to heavy events depend significantly on altitude.
Variability of seasonal floods in the Upper Danube River basin
Authors: Jeneiová Katarína , Kohnová Silvia , Hall Julia , Parajka Juraj 
Published: October 2016

Abstract
The objective of this study is to analyse the spatial variability of seasonal flood occurrences in the Upper Danube region for the period 1961-2010. The analysis focuses on the understanding of the factors that control the spatial variability of winter and summer floods in 88 basins with different physiographic conditions. The evaluation is based on circular statistics, which compare the changes in the mean date and in the seasonal flood concentration index within a year or predefined season.
The results indicate that summer half-year and winter half-year floods are dominant in the Alps and northern Danube tributaries, respectively. A comparison of the relative magnitude of flood events indicates that summer half-year floods are on average more than 50% larger than floods in winter. The evaluation of flood occurrence showed that the values of seasonal flood concentration index (median 0.75) in comparison to the annual floods (median 0.58) shows higher temporal concentration of floods. The flood seasonality of winter events is dominant in the Alps; however, along the northern fringe (i.e. the Isar, Iller and Inn River) the timing of winter half-year floods is diverse. The seasonal concentration of summer floods tends to increase with increasing mean elevation of the basins. The occurrence of the three largest summer floods is more stable, i.e. they tend to occur around the same time for the majority of analysed basins. The results show that fixing the summer and winter seasons to specific months does not always allow a clear distinction of the main flood generation processes. Therefore, criteria to define flood typologies that are more robust are needed for regions such as the Upper Danube, with large climate and topographical variability between the lowland and high elevations, particularly for the assessment of the effect of increasing air temperature on snowmelt runoff and associated floods.
Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy
Authors: Yang Lin , Li Dunchen , Chen Shuying 
Published: October 2016

Abstract
This study retrospectively analyzed the efficacy of hydrogen water in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE) and its effect on serum neuron-specific enolase (NSE), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) levels.
Forty newborns with HIE who received treatment from April 2014 to April 2015 were divided into a conventional care group and a hydrogen water group according to the different treatment methods applied. Twenty healthy full-term newborns comprised the control group. In the hydrogen water group, 5-mL/kg hydrogen water was orally administered two days after birth daily for 10 days in addition to conventional treatment. After 10 days, efficacy indicators were examined in the HIE groups. The NSE, IL-6, and TNF-α levels were compared among all three groups.
The efficacy indicators were significantly lower in the hydrogen water group compared with the conventional group. Before treatment, the serum NSE, IL-6, and TNF-α levels in the HIE groups were higher than those in the control group. After treatment, these levels in the hydrogen water group were lower than those in the conventional group.
Hydrogen water lowers serum NSE, IL-6, and TNF-α levels in HIE newborns, thereby exerting a protective effect.
Influence of a thin metal layer on a beam propagation in a biconical optical fibre taper
Authors: Stasiewicz K.A. , Moś J.E. 
Published: October 2016

AbstractThe paper presents results of a simulation of the plasmon effect achieved between a thin precious metal layer and a biconical optical fibre taper, manufactured on a standard single mode fibre. Gold, silver and titanium were used as a metal which fulfilled a cladding function for a small diameter structure. For simulation Mode Solution software was used on which modal and frequency analyses of a wavelength were provided in the range of 800–1700 nm. A displacement of a plasmon pick in dependence of thickness of a deposited precious layer for the highest plasmon effects was observed.