bluuebunny/crossref_metadata_2025_split huggingface dataset:
Independent prognostic factors for posttransplant survival in hepatocellular carcinoma patients undergoing liver transplantation
Authors: Xing Minzhi , Kim Hyun S. 
Published: November 2016

AbstractThe aim of this study was to investigate longitudinal trends in locoregional therapy (LRT) use in hepatocellular carcinoma (HCC) patients listed for transplant, and evaluate independent prognostic factors for overall survival (OS) in HCC patients undergoing orthotopic liver transplantation (OLT). The United Network for Organ Sharing (UNOS) database was used to identify HCC patients listed for liver transplantation from 1988 to 2014, and longitudinal rates of bridging LRT were calculated. OLT recipients listed from 2002 to 2013 and transplanted up to 2014, with ≥1 year of follow‐up were further analyzed. OS was compared between patients receiving bridging LRT versus none, high versus low wait times (HWT vs. LWT), and by geographic region. Bridging LRT use in the US has increased dramatically over 25 years, with more than 50% of listed patients receiving at least 1 LRT in 2014. Of 17,291 HCC patients listed for LT from 2002 to 2013, 14,511 received OLT, mean age 57.4 years, 76.8% male; 3889 received bridging LRT. Comparison groups were similar for gender, race, body mass index (BMI), HCC etiology, and biological MELD scores (P > 0.05). Significant differences in mean OS in regions with HWT/high LRT (122.4 months), HWT/low LRT (104.5 months), LWT/high LRT (104.2 months), and LWT/low LRT (102.3 months) were observed, P = 0.0006. Recipient age, donor age, bridging LRT, and longer wait times were independent prognostic factors of survival from OLT. Increasing longitudinal trends in bridging LRT for HCC patients were observed. Younger age, younger donor age, high wait times, and bridging LRT were significant independent prognostic factors for prolonged survival from transplant.
Atmospheric harmony in the retail environment: Its influence on store satisfaction and re‐patronage intention
Authors: Garaus Marion 
Published: November 2016

AbstractTo trigger positive consumer responses, retailers spend large sums of money on arousing and entertaining store environment designs that do not always produce the desired positive consumer reactions. The current research provides a theoretical framework that offers an alternate explanation for shopper preferences regarding retail environments. Drawing on consumers' need for an environment that promotes understanding, this study indicates the importance of communicating a coherent store environment to effect store satisfaction and re‐patronage intention. Harmonious store environments facilitate understanding and comprehension; they enhance information processing and pleasure judgment. One laboratory experiment and one field experiment tested the proposed research framework. Insights from evolutionary and aesthetic psychology, consumer behavior research, and the Asian practice of Feng Shui all guided the manipulation of music and aesthetic design variables to create atmospheric harmony. The findings of both studies suggest that harmonious store environments increase pleasure and positively impact shopping satisfaction and re‐patronage intent, as mediated by shopping value. These findings offer a new perspective for creating pleasant store environments. Theoretical and practical implications are discussed. Copyright © 2016 John Wiley & Sons, Ltd.
A light‐colored region of caudal fin: a niche of melanocyte progenitors in crucian carp (Cyprinus carpio L.)
Authors: Huang Yaping , Luo Yurong , Liu Jinhui , Gui Saiyu , Wang Mei , Liu Wenbin , Peng Liangyue , Xiao Yamei 
Published: November 2016

AbstractMelanocyte stem cells are a population of immature cells which sustain the self‐renewal and replenish the differentiated melanocytes. In this research, a light‐colored region (LCR) is observed at the heel of caudal fin in juvenile crucian carp. By cutting off the caudal fin, the operated caudal fin can regenerate in accordance with the original pigment pattern from the retained LCR. As markers of stem cells, Oct4 and Sox2 have been found to be highly expressed in the LCR as well as Mitfa, a label of the melanoblasts. In vitro, Mitfa+ melanoblasts are observed in the cells which are derived from the LCR and transfected with Mitfa‐EGFP reporter by using Tol2 transposon system. Furthermore, by real‐time qPCR, it is shown that the level of sox2 mRNA is gradually decreased from the LCR to proximal and distal caudal fin, and that of mitfa mRNA in the proximal caudal fin (PCF) is higher than that in the LCR, while it is the lowest in the distal caudal fin. Hence, we propose that the LCR is a pigment progenitor niche, sending melanocytes to the distal of caudal fin, which gradually emerges as caudal fin grow. We reveal that the LCR of caudal fin might be a niche of pigment progenitors, and contribute to pigment‐producing stem cells in crucian carp.
Cost awareness decreases total percutaneous coronary intervention procedural cost: The SHOPPING (Show How Options in Price for Procedures Can Be Influenced Greatly) trial
Authors: Asher Elad , Mansour John , Wheeler Adam , Kendrick Daniel , Cunningham Michael , Parikh Sahil , Zidar David , Harford Todd , Simon Daniel I. , Kashyap Vikram S. 
Published: November 2016

ObjectivesWe initiated the SHOPPING Trial (Show How Options in Price for Procedures can be InflueNced Greatly) to see if percutaneous coronary intervention (PCI) procedures can be performed at a lower cost in a single institution.BackgroundProcedural practice variability is associated with inefficiency and increased cost. We hypothesized that announcing costs for all supplies during a catheterization procedure and reporting individual operator cost relative to peers would spur cost reduction without affecting clinical outcomes.MethodsBaseline costs of 10 consecutive PCI procedures performed by 9 interventional cardiologists were documented during a 90‐day interval. Costs were reassessed after instituting cost announcing and peer reporting the next quarter. The intervention involved labeling of all endovascular supplies, equipment, devices, and disposables in the catheterization laboratory and announcement of the unit price for each piece when requested. For each interventionalist, procedure time and costs were measured and analyzed prior to and after the intervention.ResultsWe found that total PCI procedural cost was significantly reduced by an average of $234.77 (P = 0.01), equating to a total savings of $21,129.30 over the course of 90 PCI procedures. Major Adverse Cardiac and Cerebrovascular Event (MACCE) rates were similar during both periods (2.3% vs. 3.5%, P = NS).ConclusionsAnnouncing costs in the catheterization laboratory during single vessel PCI and peer reporting leads to cost reduction without affecting clinical outcomes. This intervention may have a role in more complex coronary and peripheral interventional procedures, and in other procedural areas where multiple equipment and device alternatives with variable costs are available. © 2016 Wiley Periodicals, Inc.
Incidence and predictors of permanent pacemaker implantation following treatment with the repositionable Lotus™ transcatheter aortic valve
Authors: Zaman Sarah , McCormick Liam , Gooley Robert , Rashid Hashrul , Ramkumar Satish , Jackson Damon , Hui Samuel , Meredith Ian T. 
Published: November 2016

ObjectivesTo determine the incidence and predictors of permanent pacemaker (PPM) requirement following transcatheter aortic valve replacement (TAVR) with the mechanically expanded LotusTM Valve System (Boston Scientific).BackgroundPacemaker implantation is the most common complication following TAVR. Predictors of pacing following TAVR with the Lotus valve have not been systematically assessed.MethodsConsecutive patients with severe aortic stenosis who underwent Lotus valve implantation were prospectively recruited at a single‐centre. Patients with a pre‐existing PPM were excluded. Baseline ECG, echocardiographic and multiple detector computed tomography as well as procedural telemetry and depth of implantation were independently analyzed in a blinded manner. The primary endpoint was 30‐day incidence of pacemaker requirement (PPM implantation or death while pacing‐dependent). Multivariate analysis was performed to identify independent predictors of the primary endpoint.ResultsA total of 104 consecutive patients underwent TAVR with the Lotus valve with 9/104 (9%) with a pre‐existing PPM excluded. New or worsened procedural LBBB occurred in 78%. Thirty‐day incidence of the primary pacing endpoint was 28%. The most common indication for PPM implantation was complete heart block (CHB) (69%). Independent predictors of the primary endpoint included pre‐existing RBBB (hazard ratio [HR] 2.8, 95% CI 1.1–7.0; P = 0.032) and depth of implantation below the noncoronary cusp (NCC) (HR 2.4, 95% CI 1.0–5.7; P = 0.045).ConclusionsAlmost a third of Lotus valve recipients require pacemaker implantation within 30 days. The presence of pre‐existing RBBB and the depth of prosthesis implantation below the NCC were significant pacing predictors. © 2016 Wiley Periodicals, Inc.
Catheter ablation of ventricular ectopy with para‐hisian origin: importance of mapping both sides of the interventricular septum and understanding when to stop ablating
Authors: Madaffari Antonio , Große Anett , Raffa Santi , Frommhold Markus , Fink Agnes , Geller J. Christoph 
Published: November 2016

Key Clinical MessageCatheter ablation of para‐Hisian premature ventricular contractions (PVCs) still represents a challenge and is a compromise between success and inadvertent AV block. We describe a possible strategy to address PVCs from this location with high‐amplitude His‐bundle potentials at the site of earliest activation.
Contrast‐enhanced transoral carotid ultrasonography for the evaluation of a long stenotic lesion in the internal carotid artery
Authors: Hagiwara Yuta , Yoshie Tomohide , Shimizu Takahiro , Ogura Hana , Akamatsu Masashi , Fukano Takayuki , Takada Tatsuro , Nogoshi Shinji , Ueda Toshihiro , Hasegawa Yasuhiro 
Published: November 2016

Key Clinical MessageContrast‐enhanced transoral carotid ultrasonography (CETOCU) is a novel modality for imaging the distal extracranial internal carotid artery, which is not possible with conventional carotid ultrasonography. We present a representative case that demonstrates the usefulness of CETOCU.
C‐Terminal Modification and Multimerization Increase the Efficacy of a Proline‐Rich Antimicrobial Peptide
Authors: Li Wenyi , O'Brien‐Simpson Neil M. , Yao Shenggen , Tailhades Julien , Reynolds Eric C. , Dawson Raymond M. , Otvos Laszlo , Hossain Mohammed Akhter , Separovic Frances , Wade John D. 
Published: November 2016

AbstractTwo series of branched tetramers of the proline‐rich antimicrobial peptide (PrAMP), Chex1‐Arg20, were prepared to improve antibacterial selectivity and potency against a panel of Gram‐negative nosocomial pathogens including Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa. First, tetramerization was achieved by dithiomaleimide (DTM) conjugation of two C‐terminal‐cysteine bearing dimers that also incorporated C‐terminal peptide chemical modification. DTM‐linked tetrameric peptides containing a C‐terminal hydrazide moiety on each dimer exhibited highly potent activities in the minimum inhibitory concentration (MIC) range of 0.49–2.33 μm. A second series of tetrameric analogues with C‐terminal hydrazide modification was prepared by using alternative conjugation linkers including trans‐1,4‐dibromo‐2‐butene, α,α’‐dibromo‐p‐xylene, or 6‐bismaleimidohexane to determine the effect of length on activity. Each displayed potent and broadened activity against Gram‐negative nosocomial pathogens, particularly the butene‐linked tetrameric hydrazide. Remarkably, the greatest MIC activity is against P. aeruginosa (0.77 μm/8 μg mL−1) where the monomer is inactive. None of these peptides showed any cytotoxicity to mammalian cells up to 25 times the MIC. A diffusion NMR study of the tetrameric hydrazides showed that the more active antibacterial analogues were those with a more compact structure having smaller hydrodynamic radii. The results show that C‐terminal PrAMP hydrazidation together with its rational tetramerization is an effective means for increasing both diversity and potency of PrAMP action.
Nitrogen‐Induced Transformation of Vitamin C into Multifunctional Up‐converting Carbon Nanodots in the Visible–NIR Range
Authors: Ortega‐Liebana M. Carmen , Encabo‐Berzosa M. Mar , Ruedas‐Rama M. Jose , Hueso Jose L. 
Published: November 2016

AbstractWater‐soluble, biocompatible, and photoluminescent carbon nanodots have been obtained from the rationalized carbonization of vitamin C, a well‐known antioxidant molecule in the presence of an amine co‐reactant. Herein, we describe the positive influence of N‐doping to induce a unique pH‐dependent lifetime decay response that would be potentially attractive in biological backgrounds with intrinsic fluorescence fluctuations. In addition, the selectivity and sensitivity of the N‐containing carbon nanoprobes towards the detection of copper ions at ppm levels is critically enhanced in comparison with the un‐doped counterpart, especially in the near‐infrared (NIR) range. Finally, the up‐converting properties have been also successfully applied to image tumor cells in the visible range and remarkably, in the NIR region in which minimal tissue or water absorption and maximum penetration depth are expected.
Heat‐Resistant Mechanoluminescent Chromism of the Hybrid Molecule Based on Boron Ketoiminate Modified Octasubstituted Polyhedral Oligomeric Silsesquioxane
Authors: Suenaga Kazumasa , Tanaka Kazuo , Chujo Yoshiki 
Published: November 2016

AbstractThe development of a heat‐resistant mechanoluminescent chromic (MLC) dye based on an organic–inorganic hybrid molecular scaffold is reported. Luminescent organoboron complexes were introduced into polyhedral oligomeric silsesquioxane (POSS) at each vertex through the rigid linker structure in the Suzuki–Miyaura cross‐coupling reaction. From optical measurements, it was found that the crystalline state of the modified POSS showed orange emission. By adding mechanical forces to the sample, regular structures collapsed. Correspondingly, the emission color turned to yellow. Interestingly, the yellow‐emissive amorphous state can be preserved during heating. By radially distributing luminescent chromophores on the rigid cube, both optical and thermal properties can be modulated to realize heat‐ resistant MLC behavior. POSS can contribute not only to expressing the MLC behavior, but also to improving thermal stability in the amorphous state. This is the first example, to the best of our knowledge, to offer the rational design of a heat‐resistant MLC material.
Quenching the Quantum Tunneling of Magnetization in Heterometallic Octanuclear {TMIII4DyIII4} (TM=Co and Cr) Single‐Molecule Magnets by Modification of the Bridging Ligands and Enhancing the Magnetic Exchange Coupling
Authors: Vignesh Kuduva R. , Langley Stuart K. , Murray Keith S. , Rajaraman Gopalan 
Published: November 2016

AbstractWe report the synthesis, structural characterisation, magnetic properties and provide an ab initio analysis of the magnetic behaviour of two new heterometallic octanuclear coordination complexes containing CoIII and DyIII ions. Single‐crystal X‐ray diffraction studies revealed molecular formulae of [CoIII4DyIII4(μ‐OH)4(μ3‐OMe)4{O2CC(CH3)3}4(tea)4 (H2O)4]⋅4 H2O (1) and [CoIII4DyIII4(μ‐F)4(μ3‐OH)4(o‐tol)8(mdea)4]⋅ 3 H2O⋅EtOH⋅MeOH (2; tea3−=triply deprotonated triethanolamine; mdea2−=doubly deprotonated N‐methyldiethanolamine; o‐tol=o‐toluate), and both complexes display an identical metallic core topology. Furthermore, the theoretical, magnetic and SMM properties of the isostructural complex, [CrIII4DyIII4(μ‐F4)(μ3‐OMe)1.25(μ3‐OH)2.75(O2CPh)8(mdea)4] (3), are discussed and compared with a structurally similar complex, [CrIII4DyIII4(μ3‐OH)4(μ‐N3)4(mdea)4(O2CC(CH3)3)4] (4). DC and AC magnetic susceptibility data revealed single‐molecule magnet (SMM) behaviour for 1–4. Each complex displays dynamic behaviour, highlighting the effect of ligand and transition metal ion replacement on SMM properties. Complexes 2, 3 and 4 exhibited slow magnetic relaxation with barrier heights (Ueff) of 39.0, 55.0 and 10.4 cm−1 respectively. Complex 1, conversely, did not exhibit slow relaxation of magnetisation above 2 K. To probe the variance in the observed Ueff values, calculations by using CASSCF, RASSI‐SO and POLY_ANISO routine were performed on these complexes to estimate the nature of the magnetic coupling and elucidate the mechanism of magnetic relaxation. Calculations gave values of JDy–Dy as −1.6, 1.6 and 2.8 cm−1 for complexes 1, 2 and 3, respectively, whereas the JDy–Cr interaction was estimated to be −1.8 cm−1 for complex 3. The developed mechanism for magnetic relaxation revealed that replacement of the hydroxide ion by fluoride quenched the quantum tunnelling of magnetisation (QTM) significantly, and led to improved SMM properties for complex 2 compared with 1. However, the tunnelling of magnetisation at low‐lying excited states was still operational for 2, which led to low‐temperature QTM relaxation. Replacement of the diamagnetic CoIII ions with paramagnetic CrIII led to CrIII⋅⋅⋅DyIII coupling, which resulted in quenching of QTM at low temperatures for complexes 3 and 4. The best example was found if both CrIII and fluoride were present, as seen for complex 3, for which both factors additively quenched QTM and led to the observation of highly coercive magnetic hysteresis loops above 2 K. Herein, we propose a synthetic strategy to quench the QTM effects in lanthanide‐based SMMs. Our strategy differs from existing methods, in which parameters such as magnetic coupling are difficult to control, and it is likely to have implications beyond the DyIII SMMs studied herein.
pH‐Gated Chloride Transport by a Triazine‐Based Tripodal Semicage
Authors: Roy Arundhati , Saha Debasis , Mandal Prashant Sahebrao , Mukherjee Arnab , Talukdar Pinaki 
Published: November 2016

AbstractTriazine‐based preorganized tripodal receptors are reported as efficient transmembrane Cl− carriers. These receptors were designed based on triazine core and 3,7‐diazabicyclo[3.3.1]nonane arms to facilitate preorganized cavity formation. Each bicyclic arm was further functionalized to control protonation and lipophilicity, which are crucial for their efficient anion binding and effective transport through liposomal membranes. The benzyl‐substituted receptor was the most effective ion transporter followed by the pentafluorobenzyl‐substituted derivative. The nonsubstituted receptor was least active owing to its high polarity. Two active transporters were found to function as mobile carriers for Cl− via an antiport exchange mechanism. Molecular dynamic simulations with the most active receptor show a strong Cl− binding within the cavity by direct and water‐mediated H‐bonds with its N−H groups.
Scale‐up of Dry Hopping Trials: Importance of Scale for Aroma and Taste Perceptions
Authors: Schnaitter Martin , Kell Adrian , Kollmannsberger Hubert , Schüll Florian , Gastl Martina , Becker Thomas 
Published: November 2016

AbstractIn this study beers that were dry hopped in three different batch sizes were compared. The hop‐oil concentrations were measured and possible aroma‐active hop volatiles were identified in the hop pellets as well as in the beers. The analytical results were correlated with the tasting results from a trained tasting panel. Mass transfer rates were not comparable between the different scales, and significant differences could be detected by the tasters. The beers dry hopped on an industrial scale are not comparable in flavor and odor to those dry hopped on a laboratory scale.
Determination of Hg2+ in Tap Water Based on the Electrochemiluminescence of Ru(phen)32+ and Thymine at Bare and Graphene Oxide‐Modified Glassy Carbon Electrodes
Authors: Gao Yulong , Wang Tao , Liu Fengyu 
Published: November 2016

AbstractThe electrochemiluminescence (ECL) of the Ru(phen)32+/thymine (T) system at bare and graphene oxide (GO)‐modified glassy carbon (GC) electrodes was utilized to determine Hg2+ in tap water. The ECL intensity of Ru(phen)32+ was considerably enhanced by the addition of thymine because of the occurrence of ECL reaction between them. Subsequently, the ECL intensity of Ru(phen)32+/T system rapidly decreased with the addition of Hg2+ because of the formation of a T‐Hg2+‐T complex. A linear response (R2=0.9914) was obtained over a Hg2+ concentration range of 1.0×10−9 mol/L to 1.0×10−5 mol/L with a detection limit of 3.4×10−10 mol/L at a bare GC electrode in 0.1 mol/L phosphate buffer (pH=8.0). The detection limit can be further reduced to 4.2×10−12 mol/L after modification of the GC electrode by GO. To verify its applicability, the proposed method was utilized to determine Hg2+ in tap water and simulated wastewater. The method exhibited good reproducibility and stability and thus reveals the possibility of developing a novel ECL detection method for Hg2+.
Gaussian process emulators for spatial individual‐level models of infectious disease
Authors: Pokharel Gyanendra , Deardon Rob 
Published: November 2016

AbstractStatistical inference for spatial models of infectious disease spread is often very computationally expensive. These models are generally fitted in a Bayesian Markov chain Monte Carlo (MCMC) framework, which requires multiple iterations of the computationally cumbersome likelihood function. We here propose a method of inference based on so‐called emulation techniques. Once again the method is set in a Bayesian MCMC context, but avoids calculation of the computationally expensive likelihood function by replacing it with a Gaussian process approximation of the likelihood function built from simulated data. We show that such a method can be used to infer the model parameters and underlying characteristics of the spatial disease system, and this can be done in a computationally efficient manner. The Canadian Journal of Statistics 44: 480–501; 2016 © 2016 Statistical Society of Canada
GABAergic innervation of the ciliary ganglion in macaque monkeys – A light and electron microscopic study
Authors: Barnerssoi Miriam , May Paul J. , Horn Anja K. E. 
Published: November 2016

AbstractThe vertebrate ciliary ganglion (CG) is a relay station in the parasympathetic pathway activating the iris sphincter and ciliary muscle to mediate pupillary constriction and lens accommodation, respectively. While the postganglionic motoneurons in the CG are cholinergic, as are their inputs, there is evidence from avian studies that GABA may also be involved. Here, we used light and electron microscopic methods to examine the GABAergic innervation of the CG in Macaca fascicularis monkeys. Immunohistochemistry for the gamma aminobutyric acid synthesizing enzyme glutamic acid decarboxylase (GAD) and choline acetyltransferase (ChAT) revealed that all CG neurons are contacted by ChAT‐positive terminals. A subpopulation of 17.5% of CG neurons was associated with terminal boutons expressing GAD‐immunoreactivity in addition. Double‐labeling for GAD and synaptophysin confirmed that these were synaptic terminals. Electron microscopic analysis in conjunction with GABA‐immunogold staining showed that (1) GAD‐positive terminals mainly target dendrites and spines in the perisomatic neuropil of CG neurons; (2) GABA is restricted to a specific terminal type, which displays intermediate features lying between classically excitatory and inhibitory endings; and (3) if a CG neuron is contacted by GABA‐positive terminals, virtually all perisomatic terminals supplying it show GABA immunoreactivity. The source of this GABAergic input and whether GABA contributes to a specific CG function remains to be investigated. Nevertheless, our data indicate that the innervation of the ciliary ganglion is more complex than previously thought, and that GABA may play a neuromodulatory role in the control of lens or pupil function. J. Comp. Neurol. 525:1517–1531, 2017. © 2016 Wiley Periodicals, Inc.