bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosoziale Interventionen für sexuelle
Funktionsstörungen bei Frauen
Authors: Schmidt Hannah Maren , Höhna Cindy , Widmeier Eugen , Berner Michael Martin 
Published: October 2017

ZusammenfassungDiese Arbeit gibt eine systematische Übersicht über Studien zur Wirksamkeit
psychosozialer Interventionen bei Frauen mit sexuellen Funktionsstörungen. Die
eingeschlossenen Studien sind randomisierte kontrollierte Studien (RCT) und
kontrollierte klinische Studien (CCT), publiziert zwischen 1985 und 2014, welche
mindestens eine psychosoziale Intervention im Vergleich zu einer aktiven
Vergleichsgruppe (z. B. andere psychosoziale Intervention, medikamentöse oder
somatische Behandlung) oder Kontrollgruppe (z. B. Warteliste, Placebo)
untersuchen. Die Diagnose der sexuellen Funktionsstörung muss formal nach
ICD-10/9 oder DSM-IV/III-R oder durch eine Fachperson gestellt worden sein.
Studiencharakteristika und Ergebnisse sind durch zwei unabhängige Rater_innen
nach einem standardisierten Manual extrahiert worden, ebenso das Risiko einer
systematischen Verzerrung (Risk of Bias). Wir haben 19 Studien eingeschlossen.
Sexuell bedingte Schmerzen werden am häufigsten untersucht. Die meisten
psychosozialen Interventionen zeigen signifikante Verbesserungen im Vergleich zu
einer Wartekontrollgruppe für verminderte sexuelle Appetenz und sexuell bedingte
Schmerzen, wobei die Effekte über eine Follow-up-Periode meist erhalten bleiben.
Für Orgasmusstörungen sind die Ergebnisse uneinheitlich. Erregungsstörungen
werden nicht getrennt von anderen sexuellen Funktionsstörungen untersucht. Die
meisten Studien untersuchen ein kognitiv-verhaltenstherapeutisches oder ein
klassisch sexualtherapeutisches Behandlungskonzept. Eine willkommene Entwicklung
ist es, dass in den jüngsten Studien weitere, teilweise neuartige
Behandlungsansätze (z. B. interpersonelle und achtsamkeitsbasierte Ansätze sowie
expressives Schreiben) geprüft werden. Eine genaue Berichterstattung und die
Einhaltung methodischer Qualitätsstandards werden empfohlen.
Structure and dynamics of the RNAPII CTDsome with Rtt103
Authors: Jasnovidova Olga , Klumpler Tomas , Kubicek Karel , Kalynych Sergei , Plevka Pavel , Stefl Richard 
Published: October 2017

Significance
RNA polymerase II (RNAPII) not only transcribes protein coding genes and many noncoding RNA, but also coordinates transcription and RNA processing. This coordination is mediated by a long C-terminal domain (CTD) of the largest RNAPII subunit, which serves as a binding platform for many RNA/protein-binding factors involved in transcription regulation. In this work, we used a hybrid approach to visualize the architecture of the full-length CTD in complex with the transcription termination factor Rtt103. Specifically, we first solved the structures of the isolated subcomplexes at high resolution and then arranged them into the overall envelopes determined at low resolution by small-angle X-ray scattering. The reconstructed overall architecture of the Rtt103–CTD complex reveals how Rtt103 decorates the CTD platform.
The genome draft of coconut (Cocos nucifera)
Authors: Xiao Yong , Xu Pengwei , Fan Haikuo , Baudouin Luc , Xia Wei , Bocs Stéphanie , Xu Junyang , Li Qiong , Guo Anping , Zhou Lixia , Li Jing , Wu Yi , Ma Zilong , Armero Alix , Issali Auguste Emmanuel , Liu Na , Peng Ming , Yang Yaodong 
Published: October 2017

Abstract
Coconut palm (Cocos nucifera,2n = 32), a member of genus Cocos and family Arecaceae (Palmaceae), is an important tropical fruit and oil crop. Currently, coconut palm is cultivated in 93 countries, including Central and South America, East and West Africa, Southeast Asia and the Pacific Islands, with a total growth area of more than 12 million hectares [1]. Coconut palm is generally classified into 2 main categories: “Tall” (flowering 8–10 years after planting) and “Dwarf” (flowering 4–6 years after planting), based on morphological characteristics and breeding habits. This Palmae species has a long growth period before reproductive years, which hinders conventional breeding progress. In spite of initial successes, improvements made by conventional breeding have been very slow. In the present study, we obtained de novo sequences of the Cocos nucifera genome: a major genomic resource that could be used to facilitate molecular breeding in Cocos nucifera and accelerate the breeding process in this important crop. A total of 419.67 gigabases (Gb) of raw reads were generated by the Illumina HiSeq 2000 platform using a series of paired-end and mate-pair libraries, covering the predicted Cocos nucifera genome length (2.42 Gb, variety “Hainan Tall”) to an estimated ×173.32 read depth. A total scaffold length of 2.20 Gb was generated (N50 = 418 Kb), representing 90.91% of the genome. The coconut genome was predicted to harbor 28 039 protein-coding genes, which is less than in Phoenix dactylifera (PDK30: 28 889), Phoenix dactylifera (DPV01: 41 660), and Elaeis guineensis (EG5: 34 802). BUSCO evaluation demonstrated that the obtained scaffold sequences covered 90.8% of the coconut genome and that the genome annotation was 74.1% complete. Genome annotation results revealed that 72.75% of the coconut genome consisted of transposable elements, of which long-terminal repeat retrotransposons elements (LTRs) accounted for the largest proportion (92.23%). Comparative analysis of the antiporter gene family and ion channel gene families between C. nucifera and Arabidopsis thaliana indicated that significant gene expansion may have occurred in the coconut involving Na+/H+ antiporter, carnitine/acylcarnitine translocase, potassium-dependent sodium-calcium exchanger, and potassium channel genes. Despite its agronomic importance, C. nucifera is still under-studied. In this report, we present a draft genome of C. nucifera and provide genomic information that will facilitate future functional genomics and molecular-assisted breeding in this crop species.
Azole-resistant and -susceptible Aspergillus fumigatus isolates show comparable fitness and azole treatment outcome in immunocompetent mice
Authors: Lackner Michaela , Rambach Günter , Jukic Emina , Sartori Bettina , Fritz Josef , Seger Christoph , Hagleitner Magdalena , Speth Cornelia , Lass-Flörl Cornelia 
Published: October 2017

Abstract
No data are available on the in vivo impact of infections with in vitro azole-resistant Aspergillus fumigatus in immunocompetent hosts. Here, the aim was to investigate fungal fitness and treatment response in immunocompetent mice infected with A. fumigatus (parental strain [ps]) and isogenic mutants carrying either the mutation M220K or G54W (cyp51A). The efficacy of itraconazole (ITC) and posaconazole (PSC) was investigated in mice, intravenously challenged either with a single or a combination of ps and mutants (6 × 105 conidia/mouse). Organ fungal burden and clinical parameters were measured. In coinfection models, no fitness advantage was observed for the ps strain when compared to the mutants (M220K and G54W) independent of the presence or absence of azole-treatment. For G54W, M220K, and the ps, no statistically significant difference in ITC and PSC treatment was observed in respect to fungal kidney burden. However, clinical parameters suggest that in particular the azole-resistant strain carrying the mutation G54W caused a more severe disease than the ps strain. Mice infected with G54W showed a significant decline in body weight and lymphocyte counts, while spleen/body weight ratio and granulocyte counts were increased. In immunocompetent mice, in vitro azole-resistance did not translate into therapeutic failure by either ITC or PSC; the immune system appears to play the key role in clearing the infection.
Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections
Authors: Crum-Cianflone Nancy F , Lam Pamela V , Ross-Walker Sarah , Rosen Lindsey B , Holland Steven M 
Published: October 2017

AbstractCryptococcus gattii infections, especially including those with severe clinical manifestations, may be related to underlying host immunologic factors. We present 2 cases with autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF), a key cytokine in macrophage function. Immunologic evaluation for anti-GM-CSF antibodies may be important to inform management and counseling.
Genetics of Behavior in C. elegans
Authors: Walker Denise S. , Chew Yee Lian , Schafer William R. 
Published: October 2017

Abstract
The nematode Caenorhabditis elegans is among the most intensely studied animals in modern experimental biology. In particular, because of its amenability to classical and molecular genetics, its simple and compact nervous system, and its transparency to optogenetic recording and manipulation, C. elegans has been widely used to investigate how individual gene products act in the context of neuronal circuits to generate behavior. C. elegans is the first and at present the only animal whose neuronal connectome has been characterized at the level of individual neurons and synapses, and the wiring of this connectome shows surprising parallels with the micro- and macro-level structures of larger brains. This chapter reviews our current molecular- and circuit-level understanding of behavior in C. elegans. In particular, we discuss mechanisms underlying the processing of sensory information, the generation of specific motor outputs, and the control of behavioral states.
Aristotle on the Love of Friends
Authors: Badhwar Neera K. , Jones Russell E. 
Published: October 2017

Abstract
On Aristotle’s account of philia in the Nicomachean Ethics, friends who love each other because of their virtue rather than their incidental properties are most fully friends, because they love each other for who they really are. Alongside his picture of ideal virtue, Aristotle offers a realistic account on which people can develop virtue to varying extents and in different domains. His character friends are good but imperfect people who love each other for the specific way virtue takes shape in their lives, share interests and delight in each other’s company, bring out the best in each other, and pursue each other’s good for the other’s own sake. If one brackets his faulty conception of female nature, his account of moral development allows a character friendship of equals between husbands and wives, even in societies where women’s opportunities are severely limited.
Schopenhauer on Love
Authors: Ellis Fiona 
Published: October 2017

Abstract
Schopenhauer acknowledges that there is more to erotic desire than egoism, and he is anxious to distinguish it from generalized appetite. Ultimately, however, we find him paying lip service to the beloved’s “irreplaceability” only to put forward views that are ultimately in tension with it. His conception of agape is likewise problematic, and it is here that the question of asceticism comes to the fore. In what sense, if any, does asceticism involve life-denial or self-denial? What is its relation to agape? And are there any reasons why the genuine lover must pursue this path? This chapter concludes that there are such reasons, but that they can be properly articulated only within a framework that takes us beyond Schopenhauer’s official position. Schopenhauer’s relation to theism remains unclear, but the chapter shall have scotched any suggestion of an uncompromising atheism.
Love as “Something in Between”
Authors: Jollimore Troy 
Published: October 2017

Abstract
Many philosophical accounts of love hold that love is a thoroughly arational phenomenon, that it is not a response to value, or that we do not love for reasons. This chapter argues these accounts are mistaken: when we love we are typically responding to positive qualities of the beloved, and in rendering our love appropriate and intelligible these qualities provide reasons for love. However, the role of reasons in love is highly complex. This is, in part, because love’s reasons are nondeontic: love is never rationally required, no matter how many positive qualities a person may possess or how positive they may be. Although we love for reasons, there is a sense in which when we love we go beyond our reasons. Love is neither thoroughly arational nor pervasively rational; it is “something in between.”
Motivational Interviewing and Motivational Interactions for Health Behavior Change and Maintenance
Authors: McNeil Daniel W. , Addicks Sarah H. , Randall Cameron L. 
Published: October 2017

Abstract
Motivational interviewing (MI) is a patient-centered and collaborative approach to clinical care (Miller & Rollnick, 2013). This narrative review describes MI and then concentrates on evidence for its use with patients to help enhance health behaviors in a variety of settings. Because of the proliferation of research in the area, this overview necessarily is selective. This review focuses on some of the most common chronic health behavior problems, such as those associated with obesity, oral hygiene behavior, and chronic disease management. Additionally, motivational interactions (MIACTs), which are spoken and nonverbal communications from health professionals with patients, are proposed as very brief communications that are based on MI spirit and other MI principles. These MIACTs may promote positive interactions between patients and providers, enhance patient satisfaction with healthcare, and help to establish rapport, even when the time available for healthcare interactions does not allow a true implementation of MI.
Follow-up observations for the Asteroid Catalog using AKARI Spectroscopic Observations
Authors: Hasegawa Sunao , Kuroda Daisuke , Yanagisawa Kenshi , Usui Fumihiko 
Published: October 2017

Abstract
In the 1–2.5 μm range, spectroscopic observations are made on the AcuA-spec asteroids, the spectra of which were obtained in a continuous covered mode between 2.5–5.0 μm by AKARI. Based on the Bus–DeMeo taxonomy (DeMeo et al. 2009, Icarus, 202, 160), all the AcuA-spec asteroids are classified, using both published and our observational data. Additionally, taking advantage of the Bus–DeMeo taxonomy characteristics, we constrain the characteristic of each spectral type by combining the taxonomy results with the other physical observational data from colorimetry, polarimetry, radar, and radiometry. As a result, it is suggested that certain C-, Cb-, B-type, dark X-, and D-complex asteroids have spectral properties compatible with those of anhydrous interplanetary dust particles with tiny bright material, such as water ice. This supports the proposal regarding the C-complex asteroids (Vernazza et al. 2015, ApJ, 806, 204; 2017, AJ, 153, 72). A combination of the Bus–DeMeo taxonomy for AcuA-spec asteroids with other physical clues, such as the polarimetric inversion angle, radar albedo, and mid-infrared spectroscopic spectra, will be beneficial for surface material constraints from the AcuA-spec asteroid observations.
Managing chest pain in patients with concomitant left bundle-branch block
Authors: Wyant Andrew , Chatterjee Somu , Bennett Tamara 
Published: October 2017

ABSTRACT
Diagnosis and timely management of acute myocardial infarction (MI) relies heavily on the ST-segment elevation sum. Presence of concomitant left bundle-branch block (LBBB) in patients presenting with possible acute MI presents a diagnostic dilemma. The LBBB pattern distorts ST-segment changes, delaying or preventing accurate diagnosis. This article reviews the Sgarbossa criteria and ST/S ratio and presents a treatment algorithm that may help improve patient care and reduce morbidity and mortality.
Red Cell Distribution Width After Subarachnoid Hemorrhage
Authors: Fontana Vito , Bond Ottavia , Spadaro Savino , Annoni Filippo , Nobile Leda , Badenes Rafael , Volta Carlo A. , Vincent Jean-L. , Creteur Jacques , Taccone Fabio S. 
Published: October 2017

Background:
High red cell distribution width (RDW) values have been associated with increased hospital mortality in critically ill patients, but few data are available for subarachnoid hemorrhage (SAH).

Methods:
We analyzed an institutional database of adult (>18 y) patients admitted to the Department of Intensive Care after nontraumatic SAH between January 2011 and May 2016. RDW (normal value, 10.9% to 13.4%) was obtained daily from admission for a maximum of 7 days, from routine blood analysis. We recorded the occurrence of delayed cerebral ischemia (DCI), and neurological outcome (assessed using the Glasgow Outcome Scale [GOS]) at 3 months.

Results:
A total of 270 patients were included (median age 54 y—121/270 male [45%]), of whom 96 (36%) developed DCI and 109 (40%) had an unfavorable neurological outcome (GOS, 1 to 3). The median RDW on admission was 13.8 [13.3 to 14.5]% and the highest value during the intensive care unit (ICU) stay 14.2 [13.6 to 14.8]%. The RDW was high (>13.4%) in 177 patients (66%) on admission and in 217 (80%) at any time during the ICU stay. Patients with a high RDW on admission were more likely to have an unfavorable neurological outcome. In multivariable regression analysis, older age, a high WFNS grade on admission, presence of DCI or intracranial hypertension, previous neurological disease, vasopressor therapy and a high RDW (OR, 1.1618 [95% CI, 1.213-2.158]; P=0.001) during the ICU stay were independent predictors of unfavorable neurological outcome.

Conclusions:
High RDW values were more likely to result in an unfavorable outcome after SAH. This information could help in the stratification of SAH patients already on ICU admission.
Effect of Caregiver Training on the Neurodevelopment of HIV-Exposed Uninfected Children and Caregiver Mental Health: A Ugandan Cluster-Randomized Controlled Trial
Authors: Boivin Michael J. , Nakasujja Noeline , Familiar-Lopez Itziar , Murray Sarah M. , Sikorskii Alla , Awadu Jorem , Shohet Cilly , Givon Deborah , Ruiseñor-Escudero Horacio , Schut Elizabeth E. , Opoka Robert O. , Bass Judith K. 
Published: October 2017

ABSTRACT:

Objective:
Early childhood development programs typically combine healthy nutrition and cognitive stimulation in an integrated model. We separately delivered these 2 components in a cluster-randomized controlled trial to evaluate their comparative effectiveness in promoting healthy child development and caregiver mental health. This is the first study to do so for HIV-affected children and their infected mothers.

Methods:
Two hundred twenty-one HIV-exposed but uninfected child (2–3 years old) and caregiver dyads in 18 geographic clusters in Eastern Uganda were randomized by cluster to receive biweekly individualized sessions of either (1) Mediational Intervention for Sensitizing Caregivers (MISC) training emphasizing cognitive stimulation or (2) Uganda Community Based Association for Child Welfare (UCOBAC) program that delivered health and nutrition training. Children were evaluated at baseline, 6 months, 1 year (training conclusion), and 1-year posttraining with the Mullen Scales of Early Learning (MSEL), the Color-Object Association Test for memory, the Early Childhood Vigilance Test of attention, and the Behavior Rating Inventory of Executive Function (BRIEF-parent). The Caldwell Home Observation for the Measurement of the Environment (HOME) was completed by observers to gauge caregiving quality after training. Caregiver depression/anxiety (Hopkins Symptom Checklist-25) and functionality (list of activities of daily living) were also evaluated. Data collectors were blinded to trial arm assignment.

Results:
Mediational Intervention for Sensitizing Caregivers resulted in significantly better quality of caregiving compared with UCOBAC midintervention with an adjusted mean difference (MadjDiff) of 2.34 (95% confidence interval [CI]: 1.54–3.15, p < .01), postintervention (MadjDiff = 2.43, 95% CI: 1.61–3.25, p < .01), and at 1-year follow-up (MadjDiff = 2.07, 95% CI: 1.23–2.90, p < .01). MISC caregivers reported more problems on the BRIEF for their child at 1-year posttraining only (p < .01). Caregiving quality (HOME) was significantly correlated with MSEL composite performance 1-year posttraining for both the MISC and the UCOBAC trial arms. Likewise, physical growth was significantly related to child development outcomes even though it did not differ between trial arms.

Conclusion:
Even though MISC demonstrated an advantage of improving caregiving quality, it did not produce better child cognitive outcomes compared with health and nutrition training.

Trial Registration:

clinicaltrials.gov Identifier: NCT01640561.
A New Prediction Model for Local Recurrence After Curative Rectal Cancer Surgery: Development and Validation as an Asian Collaborative Study
Authors: Hida Koya , Okamura Ryosuke , Park Soo Yeun , Nishigori Tatsuto , Takahashi Ryo , Kawada Kenji , Choi Gyu-Seog , Sakai Yoshiharu 
Published: October 2017

BACKGROUND:
Local recurrence is one of the remaining problems in rectal and rectosigmoid cancer, and it is sometimes difficult to treat.

OBJECTIVE:
This study aimed to explore various factors that are highly related to local recurrence and to develop a new prediction model for local recurrence after curative resection.

DESIGN:
This is a retrospective cohort study

SETTINGS:
This study was conducted at 2 academic hospitals in Japan and Korea.

PATIENTS:
A total of 2237 patients with stage I to III rectal and rectosigmoid cancer who underwent a curative operation with a negative circumferential margin were selected.

INTERVENTIONS:
Surgical treatment was the intervention.

MAIN OUTCOME MEASURES:
Local recurrence was the primary outcome measure.

RESULTS:
A total of 1232 patients were selected, and rectosigmoid cancer with rare local recurrence (2/221) was excluded. A different set of 792 patients with rectal cancer were chosen for validation. Multivariate analysis showed the following factors as significant for local recurrence: poorly differentiated tumor (HR, 11.2; 95% CI, 4.5–28.0), tumor depth (HR, 5.0), lymph node metastasis (HR, 4.1), operative procedure (HR, 3.2), postoperative complications (HR, 2.9), tumor location (HR, 2.6), and CEA level (HR, 2.4); a new prediction score was created by using these factors. A poorly differentiated tumor was assigned 2 points, and all other factors were assigned 1 point each. Patients who scored more than 5 points (n = 21) were judged as “high risk,” with a 2-year local recurrence rate of 66.5%. The new predictive model could also separate the patients into different risk groups in the validation set. The high-risk group had higher recurrence rates than medium- and low-risk groups (2-year local recurrence rate: 41%, 15%, and 2.1%).

LIMITATIONS:
This study was limited by its retrospective nature and potential for selection bias.

CONCLUSIONS:
Seven factors were shown to be significantly correlated with the local recurrence of rectal cancer, and the usefulness of this new prediction model was demonstrated. See Video Abstract at http://links.lww.com/DCR/A429.