bluuebunny/crossref_metadata_2025_split huggingface dataset:
The STOP-AB trial protocol: efficacy and safety of discontinuing patient antibiotic treatment when physicians no longer consider it necessary
Authors: Llor Carl , Moragas Ana , Bayona Carolina , Cots Josep M , Molero José M , Ribas Joana , Fóthy Julio Francisco , Gutiérrez Isabel , Sánchez Coro , Ortega Jesús , Arranz Javier , Botanes Jenifer , Robles Purificación 
Published: June 2017

IntroductionSince 2011, the Spanish Society of Family Medicine has recommended general practitioners (GPs) to ask their patients to stop taking antibiotics when they suspect a viral infection. However, this practice is seldom used because uncertainty about diagnosis, and fear of consequences of discontinuing antibiotic therapy, as well as perceived pressure to continue prescribing antibiotics and potential conflict with patients are more of a concern for GPs than antibiotic resistance. The main objective of this study is to determine whether discontinuation of antibiotic therapy when a GP no longer considers it necessary has any impact on the number of days with severe symptoms.Methods and analysisThis is a multicentre, open-label, randomised controlled clinical trial. The study was conducted in 10 primary care centres in Spain. We included patients from 18 to 75 years of age with uncomplicated acute respiratory tract infections—acute rhinosinusitis, acute sore throat, influenza or acute bronchitis—who had previously taken any dose of antibiotic for <3 days, which physicians no longer considered necessary. The patients were randomly assigned to the usual strategy of continuing antibiotic treatment or to discontinuing antibiotic therapy. A sample size of 240 patients per group was calculated on the basis of a reduction of 1 day in the duration of severe symptoms being a clinically relevant outcome. The primary outcome was the duration of severe symptoms, that is, symptoms scored 5 or 6 by means of validated symptom diaries. Secondary outcomes included antibiotics taken, adverse events, patient satisfaction and complications within the first 3 months.Ethics and disseminationThe study was approved by the Ethical Board ofFundació Jordi Gol i Gurina(reference number: 16/093). The findings of this trial will bedisseminated through research conferences and peer-reviewed journals.Trial registration numberNCT02900820; pre-results.
Adverse childhood or adult experiences and risk of bilateral oophorectomy: a population-based case–control study
Authors: Gazzuola Rocca Liliana , Smith Carin Y , Grossardt Brandon R , Faubion Stephanie S , Shuster Lynne T , Stewart Elizabeth A , Rocca Walter A 
Published: June 2017

ObjectivesBilateral oophorectomy has commonly been performed in conjunction with hysterectomy even in women without a clear ovarian indication; however, oophorectomy may have long-term deleterious consequences. To better understand this surgical practice from the woman’s perspective, we studied the possible association of adverse childhood or adult experiences with the subsequent occurrence of bilateral oophorectomy.DesignPopulation-based case–control study.SettingOlmsted County, Minnesota (USA).ParticipantsFrom an established population-based cohort study, we sampled 128 women who underwent bilateral oophorectomy before age 46 years for a non-cancerous condition in 1988–2007 (cases) and 128 age-matched controls (±1 year).MethodsInformation about adverse experiences was abstracted from the medical records dating back to age 15 years or earlier archived in the Rochester Epidemiology Project (REP) records-linkage system. Adverse childhood experiences were summarised using the Adverse Childhood Experience (ACE) score.ResultsWe observed an association of bilateral oophorectomy performed before age 46 years with verbal or emotional abuse, physical abuse, any abuse, substance abuse in the household, and with an ACE score ≥1 experienced before age 19 years (OR=3.23; 95% CI 1.73 to 6.02; p<0.001). In women who underwent the oophorectomy before age 40 years, we also observed a strong association with physical abuse experienced during adulthood (OR=4.33; 95% CI 1.23 to 15.21; p=0.02). Several of the associations were higher in women who underwent oophorectomy at a younger age (<40 years) and in women without an ovarian indication for the surgery. None of the psychosocial or medical variables explored as potential confounders or intervening variables changed the results noticeably.ConclusionsWomen who suffered adverse childhood experiences or adult abuse are at increased risk of undergoing bilateral oophorectomy before menopause. We suggest that the association may be explained by a series of biological, emotional, and psychodynamic mechanisms.
Utilising advance care planning videos to empower perioperative cancer patients and families: a study protocol of a randomised controlled trial
Authors: Aslakson Rebecca A , Isenberg Sarina R , Crossnohere Norah L , Conca-Cheng Alison M , Yang Ting , Weiss Matthew , Volandes Angelo E , Bridges John F P , Roter Debra L 
Published: June 2017

IntroductionDespite positive health outcomes associated with advance care planning (ACP), little research has investigated the impact of ACP in surgical populations. Our goal is to evaluate how an ACP intervention video impacts the patient centredness and ACP of the patient-surgeon conversation during the presurgical consent visit. We hypothesise that patients who view the intervention will engage in a more patient-centred communication with their surgeons compared with patients who view a control video.Methods and analysisRandomised controlled superiority trial of an ACP video with two study arms (intervention ACP video and control video) and four visits (baseline, presurgical consent, postoperative 1 week and postoperative 1 month). Surgeons, patients, principal investigator and analysts are blinded to the randomisation assignment.SettingSingle, academic, inner city and tertiary care hospital. Data collection began July 16, 2015 and continues to March 2017.ParticipantsPatients recruited from nine surgical oncology clinics who are undergoing major cancer surgery.InterventionsIn the intervention arm, patients view a patient preparedness video developed through extensive engagement with patients, surgeons and other stakeholders. Patients randomised to the control arm viewed an informational video about the hospital surgical programme.Main outcomes and measuresPrimary Outcome: Patient centredness and ACP of patient-surgeon conversations during the presurgical consent visit as measured through the Roter Interaction Analysis System. Secondary outcomes: patient Hospital Anxiety and Depression Scale score; patient goals of care; patient, companion and surgeon satisfaction; video helpfulness; medical decision maker designation; and the frequency patients watch the video. Intent-to-treat analysis will be used to assess the impact of video assignment on outcomes. Sensitivity analyses will assess whether there are differential effects contingent on patient or surgeon characteristics.Ethics and disseminationThis study has been approved by the Johns Hopkins School of Medicine institutional review board and is registered on clinicaltrials.gov (NCT02489799, First received: July 1, 2015).Trial registration numberclinicaltrials.gov,NCT02489799.
Coagulation factor and protease pathways in thrombosis and cardiovascular disease
Authors: ten Cate Hugo , Hackeng Tilman M. , de Frutos Pablo García 
Published: June 2017

SummaryThe biochemical characterisation of the proteolytic pathways that constitute blood coagulation was one of the most relevant achievements in biomedical research during the second half of the 20th century. Understanding these pathways was of crucial importance for improving global health through application in haemostasis and thrombosis pathologies. Immediately after the cloning of the genes corresponding to these proteins, mutations were discovered in them that were associated with imbalances in haemostasis. Later, the importance of coagulation pathways in other pathological processes was demonstrated, such as in atherosclerosis and inflammation, both essential processes involved in vascular disease. In the present review we evaluate the concepts that have allowed us to reach the integrated vision on coagulation that we have today. The thrombo-inflammation model encompassing these aspects includes a pivotal role for the proteases of the coagulation pathway as well as the regulatory proteins thereof. These concepts illustrate the importance of the coagulation cascade in cardiovascular pathology, not only in thrombotic processes, but also in atherosclerotic processes and in the response to ischaemia-reperfusion injury, making it a central mechanism in cardiovascular disease.
The Modulation of Stationary Waves, and Their Response to Climate Change, by Parameterized Orographic Drag
Authors: van Niekerk Annelize , Scinocca John F. , Shepherd Theodore G. 
Published: June 2017

Abstract
The parameterization of orographic drag processes in atmospheric models remains uncertain because of a lack of observational and theoretical constraints on their formulation and free parameters. While previous studies have demonstrated that parameterized orographic drag acting near the surface has a significant impact on the atmospheric circulation, this work follows a more systematic approach to investigate its impacts on the large-scale circulation and the circulation response to climate change. A set of experiments with a comprehensive atmospheric general circulation model is used to ascertain the range of climatological circulations that may arise from parameter uncertainty. It is found that the Northern Hemisphere (NH) wintertime stationary wave field is strongly damped over the North Pacific (NP) and amplified over the North Atlantic (NA) as a result of increased low-level parameterized orographic drag, both of which are shown to be conducive to higher-latitude westerlies. A comparison with the stationary wave field presented in other studies suggests that the too-zonal NA jet and equatorward NP jet biases that are prevalent in climate models may be at least partly due to their representation of orographic drag. The amplitude of the stationary wave response to climate change across the experiments is shown to scale with the magnitude of low-level parameterized orographic drag through its influence on the present-day climatological stationary wave amplitudes over different sectors of the NH, which is consistent with linear stationary wave theory. This work highlights the importance of fidelity in a model’s basic state for regional climate change projections.
Derivation of Wind Vectors from AVHRR/MetOp at EUMETSAT
Authors: Hautecoeur Olivier , Borde Régis 
Published: June 2017

AbstractAtmospheric motion vectors (AMVs) are derived operationally at EUMETSAT from the AVHRR/3 instrument on the Polar System satellite MetOp-A since 2011. The launch of MetOp-B in 2012 allowed for doubling of the production of AMVs over the polar regions using both MetOp-A and MetOp-B satellite data. In addition to the single AVHRR polar wind product, in 2014 EUMETSAT developed a new global AVHRR wind product extracted from a pair of MetOp-A and MetOp-B images. This new product is extracted using the large overlap in the imagery data obtained from the tandem configuration of the two satellites on the same orbital plane but with a phase difference of about 50 min. The tandem configuration also provides the possibility to derive wind vectors over polar areas using a triplet of AVHRR images, keeping the same time period necessary to derive the single MetOp polar wind product but allowing for a temporal consistency check in the calculation of the AMV quality index. Three different AMV products are currently extracted from AVHRR imagery at EUMETSAT, using two or three images taken by one or two satellites having different coverage and time integration.This paper describes the scientific concept of the AVHRR wind extraction algorithm developed at EUMETSAT and presents the performances of the various AVHRR wind products. Intercomparisons of these different products highlight the role of the temporal gap between the images used to extract the wind and the impact of the consistency check on the calculation of the quality index.
Impact of Storm Size on Prediction of Storm Track and Intensity Using the 2016 Operational GFDL Hurricane Model
Authors: Bender Morris A. , Marchok Timothy P. , Sampson Charles R. , Knaff John A. , Morin Matthew J. 
Published: June 2017

Abstract
The impact of storm size on the forecast of tropical cyclone storm track and intensity is investigated using the 2016 version of the operational GFDL hurricane model. Evaluation was made for 1529 forecasts in the Atlantic, eastern Pacific, and western North Pacific basins, during the 2014 and 2015 seasons. The track and intensity errors were computed from forecasts in which the 34-kt (where 1 kt = 0.514 m s−1) wind radii obtained from the operational TC vitals that are used to initialize TCs in the GFDL model were replaced with wind radii estimates derived using an equally weighted average of six objective estimates. It was found that modifying the radius of 34-kt winds had a significant positive impact on the intensity forecasts in the 1–2 day lead times. For example, at 48 h, the intensity error was reduced 10%, 5%, and 4% in the Atlantic, eastern Pacific, and western North Pacific, respectively. The largest improvements in intensity forecasts were for those tropical cyclones undergoing rapid intensification, with a maximum error reduction in the 1–2 day forecast lead time of 14% and 17% in the eastern and western North Pacific, respectively. The large negative intensity biases in the eastern and western North Pacific were also reduced 25% and 75% in the 12–72-h forecast lead times. Although the overall impact on the average track error was neutral, forecasts of recurving storms were improved and tracks of nonrecurving storms degraded. Results also suggest that objective specification of storm size may impact intensity forecasts in other high-resolution numerical models, particularly for tropical cyclones entering a rapid intensification phase.
Postoperative complications associated with external skeletal fixators in cats
Authors: Beever Lee , Giles Kirsty , Meeson Richard 
Published: June 2017

Objectives: The objective of this study was to quantify complications associated with external skeletal fixators (ESFs) in cats and to identify potential risk factors. Methods: A retrospective review of medical records and radiographs following ESF placement was performed. Results: Case records of 140 cats were reviewed; fixator-associated complications (FACs) occurred in 19% of cats. The region of ESF placement was significantly associated with complication development. Complications developed most frequently in the femur (50%), tarsus (35%) and radius/ulna (33%). Superficial pin tract infection (SPTI) and implant failure accounted for 45% and 41% of all FACs, respectively. SPTI occurred more frequently in the femur, humerus and tibia, with implant failure more frequent in the tarsus. No association between breed, age, sex, weight, fracture type (open vs closed), ESF classification, number of pins per bone segment, degree of fracture load sharing, and the incidence or type of FAC was identified. No association between region of placement, breed, age, sex, weight, fracture type (open vs closed), ESF classification, number of pins per bone segment, fracture load sharing and the time to complication development was identified. Conclusions and relevance: Complication development is not uncommon in cats following ESF placement. The higher complication rate in the femur, tarsus and radius/ulna should be considered when reviewing options for fracture management. However, cats appear to have a lower rate of pin tract infections than dogs.
The feline blood film: 2. Leukocyte and platelet morphology
Authors: Harvey John W 
Published: June 2017

Practical relevance: Many veterinary practices have invested in quality automated hematology instruments for use in-house. However, regardless of their specific choice of analyzer, there are important hematology findings that can only be determined by microscopic examination of stained blood films. For this reason, and also for the purpose of quality control for the analyzer, a quick blood film review should be performed alongside every automated complete blood count. Even those practices that submit their blood samples to outside diagnostic laboratories for evaluation, still require the capability to examine stained blood films in emergency situations. Series outline: This is the second of a two-part article series that aims to familiarize the practitioner with normal findings on feline blood films, with a particular focus on unique features in the cat, as well as to assist with interpretation of common abnormalities. Part 2 focuses on the morphology of feline leukocytes and platelets in health and disease. Evidence base: The information and guidance offered is based on the published literature and the author’s own extensive clinical pathology research.
Bench behaviour of ice hockey coaches: Psychophysiological and verbal responses to critical game incidents
Authors: Kennedy Michael D , Knight Camilla J 
Published: June 2017

The purpose of this study was to examine coaches’ psychophysiological and verbal responses to different game situations. The in-game heart rate and verbal responses of three elite ice hockey coaches to four critical game incidents (Goals For/Against; Penalties Taken/Drawn) over four university women’s games were assessed. Verbal comments were categorised using the Coach Behaviour Assessment System, and then comments and heart rate were sequenced to critical incidents recorded on video review. Overall, in-game heart rate was greater than rest and coaches were rarely silent. General encouragement and general commentary were the most common verbal comments. Two hundred and eight critical incident comments were recorded (Goals For/Against 34.6 %; Penalties Taken/Drawn 65.4%) associated with a 10 bpm greater heart rate. Most common verbal responses to critical incidents were general commentary, silence and organisation. The type of comment was affected by the type of critical incident. In 78% of critical incidents, the type of comment made before incidents differed to type of comment after the incident, coaches rarely talked at the same time and silence was common. These novel findings are limited to ice hockey coaches given the small sample size. However, these results should encourage more research into the psychophysiological and verbal responses of coaches in other team sports real game situations to better understand in game coaching behaviour.
Retrospective analysis of capillary hemoglobin recovery in nearly 1 200 000 blood donor returns
Authors: Niittymäki Pia , Arvas Mikko , Larjo Antti , Mattila Pirkko , Ihalainen Jarkko , Syrjälä Martti , Castrén Johanna , Partanen Jukka 
Published: June 2017

Key Points
We used a registry containing all 1 163 524 blood donor returns that took place in Finland between 2010 and 2015 to evaluate cHb recovery. Average recovery times for cHb to return to the level of the preceding donation were longer than the minimum allowed donation intervals.
Eph/Ephrin Signaling Controls Progenitor Identities In The Ventral Spinal Cord
Authors: Laussu Julien , Audouard Christophe , Kischel Anthony , Assis-Nascimento Poincyane , Escalas Nathalie , Liebl Daniel J. , Soula Cathy , Davy Alice 
Published: June 2017

Abstract

Background
In the vertebrate spinal cord, motor neurons (MN) are generated in stereotypical numbers from a pool of dedicated progenitors (pMN) whose number depends on signals that control their specification but also their proliferation and differentiation rates. Although the initial steps of pMN specification have been extensively studied, how pMN numbers are regulated over time is less well characterized.

Results
Here, we show that ephrinB2 and ephrinB3 are differentially expressed in progenitor domains in the ventral spinal cord with several Eph receptors more broadly expressed. Genetic loss-of-function analyses show that ephrinB2 and ephrinB3 inversely control pMN numbers and that these changes in progenitor numbers correlate with changes in motor neuron numbers. Detailed phenotypic analyses by immunostaining and genetic interaction studies between ephrinB2 and Shh indicate that changes in pMN numbers in ephrin mutants are due to alteration in progenitor identity at late stages of development.

Conclusions
Altogether our data reveal that Eph:ephrin signaling is required to control progenitor identities in the ventral spinal cord.
Single‐cell RNA‐sequencing of the brain
Authors: Cuevas‐Diaz Duran Raquel , Wei Haichao , Wu Jia Qian 
Published: June 2017

AbstractSingle‐cell RNA‐sequencing (scRNA‐seq) is revolutionizing our understanding of the genomic, transcriptomic and epigenomic landscapes of cells within organs. The mammalian brain is composed of a complex network of millions to billions of diverse cells with either highly specialized functions or support functions. With scRNA‐seq it is possible to comprehensively dissect the cellular heterogeneity of brain cells, and elucidate their specific functions and state. In this review, we describe the current experimental methods used for scRNA‐seq. We also review bioinformatic tools and algorithms for data analyses and discuss critical challenges. Additionally, we summarized recent mouse brain scRNA‐seq studies and systematically compared their main experimental approaches, computational tools implemented, and important findings. scRNA‐seq has allowed researchers to identify diverse cell subpopulations within many brain regions, pinpointing gene signatures and novel cell markers, as well as addressing functional differences. Due to the complexity of the brain, a great deal of work remains to be accomplished. Defining specific brain cell types and functions is critical for understanding brain function as a whole in development, health, and diseases.
Effect of cochlear implant surgery on vestibular function: Meta-analysis study
Authors: Ibrahim Iman , da Silva Sabrina Daniela , Segal Bernard , Zeitouni Anthony 
Published: June 2017

Importance Vestibular disorders have been reported following cochlear implant (CI) surgery, but the literature shows a wide discrepancy in the reported clinical impact. The aim of this meta-analysis is to quantify the effect of CI before and after surgery on the outcomes of vestibular tests, postural stability, and subjective perception of dizziness. Objective To evaluate the effects of CI surgery on vestibular function in adult patients (≥18 years) with sensorineural hearing loss who underwent unilateral or bilateral implantation. Data sources MEDLINE, PubMed, Web of Science and Cochrane Library from January 1, 1995, through July 12, 2016. Study selection Published studies of adult patients who received unilateral or bilateral CIs and whose vestibular function or postural stability was assessed before and after surgery. Data extraction From each study, test results before and after surgery were compared, for the following five tests: clinical head impulse test (HIT); bi-thermal caloric irrigation of the horizontal semicircular canal; vestibular evoked myogenic potential (VEMP); dizziness handicap inventory (DHI); and computerized dynamic posturography (CDP). Results Twenty-seven studies met all inclusion criteria. Most studies performed either bi-thermal caloric irrigation and/or VEMP, with fewer studies investigating changes in HIT, posturography or DHI. CI surgery significantly affected the results of caloric and VEMP testing. However, HIT results, posturography, and DHI, scores were not significantly affected after CI surgery. Conclusions and relevance CI surgery has a significant negative effect on the results of caloric as well as VEMP tests. No significant effect of CI surgery was detected in HIT, posturography, or DHI scores. Overall, the clinical effect of CI surgery on the vestibular function was found to be insignificant. Nonetheless, the potential effects of surgery on the vestibular system should be discussed with CI candidates before surgery.