bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of carbohydrate in central fatigue: a systematic review
Authors: Khong T. K. , Selvanayagam V. S. , Sidhu S. K. , Yusof A. 
Published: October 2016

Carbohydrate (CHO) depletion is linked to neuromuscular fatigue during exercise. While its role at peripheral level is relatively well understood, less is known about its impact centrally. The aim of this systematic review was to critically analyze the effects of CHO on central fatigue (CF) assessed by various neurophysiological techniques. Four databases were searched using PRISMA guidelines through February 2016. The inclusion criteria were: CHO as intervention against a placebo control, fatigue induced by prolonged exercise and assessed using neurophysiological measures [voluntary activation (VA), superimposed twitch (SIT), M‐wave, electromyography], alongside maximal voluntary contraction (MVC). Seven papers were reviewed, where exercise duration lasted between 115 and 180 min. CHO improved exercise performance in three studies, whereby two of them attributed it to CF via attenuation of VA and SIT reductions, while the other indicated peripheral involvement via attenuation of M‐wave reduction. Although a few studies suggest that CHO attenuates CF, data on its direct effects on neurophysiological outcome measures are limited and mixed. Generally, measures employed in these studies were inadequate to conclude central contribution to fatigue. Factors including the techniques used and the lack of controls render additional confounding factors to make definitive deductions. Future studies should employ consistent techniques and appropriate neurophysiological controls to distinguish CHO effect at central level. The use of pharmacological intervention should be incorporated to elucidate involvement of central mechanisms.
Friends in high places: A dyadic perspective on peer status as predictor of friendship quality and the mediating role of empathy and prosocial behavior
Authors: Meuwese Rosa , Cillessen Antonius H. N. , Güroğlu Berna 
Published: October 2016

AbstractFriendships and peer status play important roles in the social landscape of adolescents and are related to developmental outcomes. Yet, how peer status is related to friendship quality and what role social skills play in this association remains unclear. In this study, we use Actor–Partner Interdependence (Mediation) Modeling (Ledermann, Macho, & Kenny, 2011) to investigate how two forms of peer status, preference and popularity, are related to positive and negative friendship quality in mid‐adolescence. Results show that adolescents who are friends with more preferred (i.e., likeable) and popular adolescents report higher friendship quality. These partner effects were partially mediated by adolescents’ own prosocial behavior and their friends’ empathy levels. Higher levels of empathy of one's friend and one's own lesser preference for equity explained why adolescents were more satisfied in a friendship with highly preferred (i.e., likeable) adolescents. Interestingly, empathy was not a mediator for the link between friendship quality and popularity. These findings promote a better understanding of the interplay between different levels of social complexity (i.e., individual, dyadic and peer group level) in adolescence.
Differential parenting and children's social understanding
Authors: Pauker Sharon , Perlman Michal , Prime Heather , Jenkins Jennifer M. 
Published: October 2016

AbstractIn the current study, a curvilinear association was examined between differential parenting and children's social understanding as measured using standardized assessments and behavioral observations. Social understanding was comprised of theory‐of‐mind and behavior indicating understanding of others’ minds (i.e., cognitive sensitivity and internal state talk and reasoning during sibling interactions). Data came from a community sample of 372 children (51.6% males; M age = 5.57, SD = 0.77), their younger siblings (M age = 3.14, SD = 0.27), and their mothers who were observed in their homes. We hypothesized that in families with higher levels of differential parenting, both favored and disfavored older siblings would display poorer social understanding, but that disfavored children would be more negatively impacted. Results from a hierarchical regression analysis indicated an inverse linear effect, rather than a curvilinear relationship, between being favored by mother and siblings’ social understanding. Specifically, disfavored older children showed higher levels of social understanding when interacting with their favored younger sibling. This relationship remained significant after controlling for variables such as age, SES, and language. Findings suggest that differential parenting plays a role in children's ability to understand others.
Adherence to secondary antibiotic prophylaxis for patients with rheumatic heart disease diagnosed through screening in Fiji
Authors: Engelman Daniel , Mataika Reapi L. , Kado Joseph H. , Ah Kee Maureen , Donath Susan , Parks Tom , Steer Andrew C. 
Published: October 2016

AbstractObjectivesEchocardiographic screening for rheumatic heart disease (RHD) can detect subclinical cases; however, adequate adherence to secondary antibiotic prophylaxis (SAP) is required to alter disease outcomes. We aimed to investigate the adherence to SAP among young people with RHD diagnosed through echocardiographic screening in Fiji and to investigate factors associated with adherence.MethodsPatients diagnosed with RHD through echocardiographic screening in Fiji from 2006 to 2014 were included. Dates of benzathine penicillin G injections were collected from 76 health clinics nationally from December 2011 to December 2014. Adherence was measured using the proportion of days covered (PDC). Multivariate logistic regression analysis was used to identify characteristics associated with any adherence (≥1 injection received) and adequate adherence (PDC ≥0.80).ResultsOf 494 patients, 268 (54%) were female and the median age was 14 years. Overall, 203 (41%) had no injections recorded and just 33 (7%) had adequate adherence. Multivariate logistic regression showed increasing age (OR 0.93 per year, 95% CI 0.87–0.99) and time since diagnosis ≥1.5 years (OR 0.53, 95% CI 0.37–0.79) to be inversely associated with any adherence. Non‐iTaukei ethnicity (OR 2.58, 95%CI 1.04–6.33) and urban residence (OR 3.36, 95% CI 1.54–7.36) were associated with adequate adherence, whereas time since diagnosis ≥1.5 years (OR 0.38, 95%CI 0.17–0.83) was inversely associated with adequate adherence.ConclusionsAdherence to SAP after screening in Fiji is currently inadequate for individual patient protection or population disease control. Secondary prevention should be strengthened before further screening can be justified.
ABI4 represses the expression of type‐A ARRs to inhibit seed germination in Arabidopsis
Authors: Huang Xiaozhen , Zhang Xiaoyan , Gong Zhizhong , Yang Shuhua , Shi Yiting 
Published: October 2016

SummaryThe plant hormone abscisic acid (ABA) plays a crucial role in regulating seed germination and post‐germination growth. ABSCISIC ACID INSENSITIVE4 (ABI4), an APETALA2 (AP2)‐type transcription factor, is required for the ABA‐mediated inhibition of seed germination. Cytokinins promote seed germination and seedling growth by antagonizing ABA signaling. However, the interaction between ABA and cytokinin signaling during seed germination remains unclear. Here, we report that ABA signaling downregulates Arabidopsis response regulators (ARRs), a class of cytokinin‐inducible genes, during seed germination and cotyledon greening. We found that the application of exogenous ABA repressed the expression of type‐A ARRs in Arabidopsis seeds and seedlings. Among the type‐A ARR family members, the expression of ARR6, ARR7 and ARR15 was upregulated in ABA‐deficient mutants, indicating that the transcriptional inhibition of type‐A ARRs requires the ABA signaling pathway. Single and multiple mutations of these ARRs resulted in increased ABA sensitivity during germination and cotyledon greening; overexpression of ARR7 or ARR15 led to an ABA‐insensitive phenotype. These observations suggest that type‐A ARRs inhibit the ABA response during seed germination and cotyledon greening. Further analysis showed that ABI4 negatively regulated the transcription of ARR6, ARR7 and ARR15 by directly binding to their promoters. Genetic analysis showed that loss‐of‐function mutations of ARR7 and ARR15 partially rescued the ABA insensitivity of abi4‐1. Thus, this study revealed that ABI4 plays a key role in ABA and cytokinin signaling by inhibiting the transcription of type‐A ARRs to inhibit seed germination and cotyledon greening.
Pretreatment leukocyte ratios and concentrations as predictors of outcome in dogs with cutaneous mast cell tumours
Authors: Skor O. , Fuchs‐Baumgartinger A. , Tichy A. , Kleiter M. , Schwendenwein I. 
Published: October 2016

AbstractLeukocyte ratios correlate with outcome in several human cancers. Little is known about their prognostic significance in mast cell tumour (MCT). The aim of the study was to evaluate the prognostic significance of pretreatment leukocyte concentrations and their ratios in dogs with MCT for survival. Medical records of 92 dogs with MCT were retrospectively reviewed. Tumour diagnosis was made by tumour biopsy or fine‐needle aspirate. Only dogs without prior treatment were included. Eosinophil, lymphocyte, monocyte and neutrophil concentration were obtained by ADVIA 2120™ (Siemens Healthcare, Vienna, Austria). Neutrophil‐to‐eosinophil ratio (NER), lymphocyte‐to‐monocyte ratio (LMR) and neutrophil‐to‐lymphocyte ratio (NLR) were calculated from collected leukocyte concentrations. Relative eosinophil concentration (REC), NER (P < 0.001), NLR (P = 0.001) and LMR (P < 0.001) were significant prognostic factors for outcome in univariate analysis. REC (P = 0.008) and NER (P = 0.001) remained independent predictors of survival in multiple analyses. Leukocyte concentrations and ratios, especially REC and NER may serve as prognostic indicators in MCT.
Risk factors for treatment‐related adverse events in cancer‐bearing dogs receiving piroxicam
Authors: Eichstadt L. R. , Moore G. E. , Childress M. O. 
Published: October 2016

AbstractPiroxicam has antitumour effects in dogs with cancer, although side effects may limit its use. The purpose of this study was to retrospectively identify factors predisposing cancer‐bearing dogs to adverse events (AEs) following piroxicam therapy. Medical records of dogs presented to the Purdue Veterinary Teaching Hospital between 2005 and 2015 were reviewed, and 137 dogs met the criteria for study inclusion. Toxic effects of piroxicam in these dogs were graded according to an established system. Multivariate logistic regression was used to estimate the extent to which certain factors affected the risk for AEs. Age [odds ratio (OR) 1.250, P = 0.009; 95% confidence interval (CI) 1.057–1.479] and concurrent use of gastroprotectant medications (OR 2.612, P = 0.025; 95% CI 1.127–6.056) significantly increased the risk for gastrointestinal AEs. The results of this study may help inform the risk versus benefit calculation for clinicians considering the use of piroxicam to treat dogs with cancer.
Acetylcholine released by endothelial cells facilitates flow‐mediated dilatation
Authors: Wilson Calum , Lee Matthew D. , McCarron John G. 
Published: October 2016

Key points
The endothelium plays a pivotal role in the vascular response to chemical and mechanical stimuli.
The endothelium is exquisitely sensitive to ACh, although the physiological significance of ACh‐induced activation of the endothelium is unknown.
In the present study, we investigated the mechanisms of flow‐mediated endothelial calcium signalling.
Our data establish that flow‐mediated endothelial calcium responses arise from the autocrine action of non‐neuronal ACh released by the endothelium.
AbstractCirculating blood generates frictional forces (shear stress) on the walls of blood vessels. These frictional forces critically regulate vascular function. The endothelium senses these frictional forces and, in response, releases various vasodilators that relax smooth muscle cells in a process termed flow‐mediated dilatation. Although some elements of the signalling mechanisms have been identified, precisely how flow is sensed and transduced to cause the release of relaxing factors is poorly understood. By imaging signalling in large areas of the endothelium of intact arteries, we show that the endothelium responds to flow by releasing ACh. Once liberated, ACh acts to trigger calcium release from the internal store in endothelial cells, nitric oxide production and artery relaxation. Flow‐activated release of ACh from the endothelium is non‐vesicular and occurs via organic cation transporters. ACh is generated following mitochondrial production of acetylCoA. Thus, we show ACh is an autocrine signalling molecule released from endothelial cells, and identify a new role for the classical neurotransmitter in endothelial mechanotransduction.
Robotic intrafractional US guidance for liver SABR: System design, beam avoidance, and clinical imaging
Authors: Schlosser Jeffrey , Gong Ren Hui , Bruder Ralf , Schweikard Achim , Jang Sungjune , Henrie John , Kamaya Aya , Koong Albert , Chang Daniel T. , Hristov Dimitre 
Published: October 2016

PurposeTo present a system for robotic 4D ultrasound (US) imaging concurrent with radiotherapy beam delivery and estimate the proportion of liver stereotactic ablative body radiotherapy (SABR) cases in which robotic US image guidance can be deployed without interfering with clinically used VMAT beam configurations.MethodsThe image guidance hardware comprises a 4D US machine, an optical tracking system for measuring US probe pose, and a custom‐designed robot for acquiring hands‐free US volumes. In software, a simulation environment incorporating the LINAC, couch, planning CT, and robotic US guidance hardware was developed. Placement of the robotic US hardware was guided by a target visibility map rendered on the CT surface by using the planning CT to simulate US propagation. The visibility map was validated in a prostate phantom and evaluated in patients by capturing live US from imaging positions suggested by the visibility map. In 20 liver SABR patients treated with VMAT, the simulation environment was used to virtually place the robotic hardware and US probe. Imaging targets were either planning target volumes (PTVs, range 5.9–679.5 ml) or gross tumor volumes (GTVs, range 0.9–343.4 ml). Presence or absence of mechanical interference with LINAC, couch, and patient body as well as interferences with treated beams was recorded.ResultsFor PTV targets, robotic US guidance without mechanical interference was possible in 80% of the cases and guidance without beam interference was possible in 60% of the cases. For the smaller GTV targets, these proportions were 95% and 85%, respectively. GTV size (1/20), elongated shape (1/20), and depth (1/20) were the main factors limiting the availability of noninterfering imaging positions. The robotic US imaging system was deployed in two liver SABR patients during CT simulation with successful acquisition of 4D US sequences in different imaging positions.ConclusionsThis study indicates that for VMAT liver SABR, robotic US imaging of a relevant internal target may be possible in 85% of the cases while using treatment plans currently deployed in the clinic. With beam replanning to account for the presence of robotic US guidance, intrafractional US may be an option for 95% of the liver SABR cases.
Associated particle neutron elemental imaging in vivo: A feasibility study
Authors: Abel Michael R. , Koltick David S. , Nie Linda H. 
Published: October 2016

PurposeThe purpose of this study is to develop a Monte Carlo simulation model for in vivo associated particle neutron elemental imaging (APNEI) and to study the feasibility of using APNEI to determine the iron distribution in a human liver with the defined model.MethodsThe model presented in this study was defined in mcnp by the basic geometry of the human body, the use of D + D source neutrons, iron as the element of interest, an iron‐containing voxel in the liver as the target region, and 2 large germanium detectors anterior and posterior to the trunk of the body. The f8 pulse height tally was employed in mcnp to determine the signal acquired from iron inelastic scatter gamma rays at various iron concentrations in the target liver voxel. Correspondingly, the f4 average flux tally in mcnp was modified by a dose function such that the equivalent dose to the whole liver and the effective dose to the whole body could be estimated and used as the basis for a limiting number of neutron histories which could feasibly allow for the collection of a sufficient volume of data to construct a 2D image of iron distribution in the liver voxel.ResultsAssuming an allowable equivalent dose to the liver of 5 mSv, 143 inelastic scatter iron gamma ray counts (at ∼847 keV) would ideally be registered at the germanium detectors for a 1 cm3 cube‐shaped liver voxel with an iron concentration of 1000 ppm. According to the simulation model, an image of iron distribution in the liver can be constructed with a 1 cm resolution at the level of 1000 ppm iron. Collecting such an image would yield an estimated whole body dose of 0.82 mSv. The mathematical introduction of image uncertainty resulting from source spot diameter and detector timing resolution more closely approximates the result of real world application.ConclusionsAPNEI of certain elements in vivo appears feasible given several timing, sensitivity, and resolution caveats. However, further study is required to determine what the detection limit of iron would be and what image resolution would be in an experimental setup as the present model contains idealized assumptions which overestimate the signal attributable to iron inelastic scatter gamma rays.
The Effect of Dietary Nitrate Supplementation on Physiology and Performance in Trained Cyclists
Authors: McQuillan Joseph A. , Dulson Deborah K. , Laursen Paul B. , Kilding Andrew E. 
Published: October 2016

Purpose:To determine the effect of dietary nitrate (NO3 –) supplementation on physiology and performance in well-trained cyclists after 6–8 d of NO3 – supplementation.Methods:Eight competitive male cyclists (mean ± SD age 26 ± 8 y, body mass 76.7 ± 6.9 kg, VO2peak 63 ± 4 mL · kg–1 · min–1) participated in a double-blind, placebo-controlled, crossover-design study in which participants ingested 70 mL of beetroot juice containing ~4 mmol NO3 – (NIT) or a NO3 –-depleted placebo (PLA), each for 8 d. Replicating pretreatment measures, participants undertook an incremental ramp assessment to determine VO2peak and first (VT1) and second (VT2) ventilatory thresholds on d 6 (NIT6 and PLA6), moderate-intensity cycling economy on d 7 (NIT7 and PLA7), and a 4-km time trial (TT) on d 8 (NIT8 and PLA8).Results:Relative to PLA, 6 d of NIT supplementation produced unclear effects for VO2peak (mean ± 95% confidence limit: 1.8% ± 5.5%) and VT1 (3.7% ± 12.3%) and trivial effects for both VT2 (–1.0% ± 3.0%) and exercise economy on d 7 (–1.0% ± 1.6%). However, effects for TT performance time (–0.7% ± 0.9%) and power (2.4% ± 2.5%) on d 8 were likely beneficial.Conclusions:Despite mostly unclear outcomes for standard physiological determinants of performance, 8 d of NO3 – supplementation resulted in likely beneficial improvements to 4-km TT performance in well-trained male endurance cyclists.
Validity of 10-HZ GPS and Timing Gates for Assessing Maximum Velocity in Professional Rugby Union Players
Authors: Roe Gregory , Darrall-Jones Joshua , Black Christopher , Shaw William , Till Kevin , Jones Ben 
Published: October 2016

Purpose:The purpose of this study was to investigate the validity of timing gates and 10-Hz global positioning systems (GPS) units (Catapult Optimeye S5) against a criterion measure (50-Hz radar gun) for assessing maximum sprint velocity (Vmax).Methods:Nine male professional rugby union players performed 3 maximal 40-m sprints with 3 min rest between efforts with Vmax assessed simultaneously via timing gates, 10-Hz GPSOpen (Openfield software), GPSSprint (Sprint software), and radar gun. Eight players wore 3 GPS units, while 1 wore a single unit during each sprint.Results:When compared with the radar gun, mean biases for GPSOpen, GPSSprint, and timing gates were trivial, small, and small, respectively. The typical error of the estimate (TEE) was small for timing gate and GPSOpen while moderate for GPSSprint. Correlations with radar gun were nearly perfect for all measures. Mean bias, TEE, and correlations between GPS units were trivial, small, and nearly perfect, respectively, while a small TEE existed when GPSOpenfield was compared with GPSSprint.Conclusion:Based on these findings, both 10-Hz GPS and timing gates provide valid measures of 40-m Vmax assessment compared with a radar gun. However, as error did exist between measures, the same testing protocol should be used when assessing 40-m Vmax over time. Furthermore, in light of the above results, it is recommended that when assessing changes in GPS-derived Vmax over time, practitioners should use the same unit for each player and perform the analysis with the same software, preferably Catapult Openfield.
Assessing the Measurement Sensitivity and Diagnostic Characteristics of Athlete-Monitoring Tools in National Swimmers
Authors: Crowcroft Stephen , McCleave Erin , Slattery Katie , Coutts Aaron J. 
Published: October 2016

Purpose:To assess measurement sensitivity and diagnostic characteristics of athlete-monitoring tools to identify performance change.Methods:Fourteen nationally competitive swimmers (11 male, 3 female; age 21.2 ± 3.2 y) recorded daily monitoring over 15 mo. The self-report group (n = 7) reported general health, energy levels, motivation, stress, recovery, soreness, and wellness. The combined group (n = 7) recorded sleep quality, perceived fatigue, total quality recovery (TQR), and heart-rate variability. The week-to-week change in mean weekly values was presented as coefficient of variance (CV%). Reliability was assessed on 3 occasions and expressed as the typical error CV%. Week-to-week change was divided by the reliability of each measure to calculate the signal-to-noise ratio. The diagnostic characteristics for both groups were assessed with receiver-operating-curve analysis, where area under the curve (AUC), Youden index, sensitivity, and specificity of measures were reported. A minimum AUC of .70 and lower confidence interval (CI) >.50 classified a “good” diagnostic tool to assess performance change.Results:Week-to-week variability was greater than reliability for soreness (3.1), general health (3.0), wellness% (2.0), motivation (1.6), sleep (2.6), TQR (1.8), fatigue (1.4), R-R interval (2.5), and LnRMSSD:RR (1.3). Only general health was a “good” diagnostic tool to assess decreased performance (AUC –.70, 95% CI, .61–.80).Conclusion:Many monitoring variables are sensitive to changes in fitness and fatigue. However, no single monitoring variable could discriminate performance change. As such the use of a multidimensional system that may be able to better account for variations in fitness and fatigue should be considered.