bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep Dysfunction and its Association to Chronic Rhinosinusitis: Updated Review
Authors: Orb Quinn , Orlandi Richard R. , Alt Jeremiah A. 
Published: February 2017

BackgroundPoor sleep has significant effects on health contributing to increased morbidity and mortality. The direct and indirect costs of sleep dysfunction total well in to the billions of dollars annually in the United States. Chronic rhinosinusitis (CRS) affects up to 16% of the US population and has been linked to poor sleep quality with up to three quarters of patients with CRS reporting poor sleep quality. There is a growing body of literature evaluating the relationship between sleep and CRS. In this review, we organize and present the current knowledge on the associations between sleep and CRS as well as identify areas for further investigation.Data sourcesA structured literature search from 1946 to 2016 was conducted in the English language using OVID MEDLINE database, PubMed, and EMBASE.Review methodsAbstracts were reviewed for relevance and appropriate studies were included in the narrative review.ResultsStudies were analyzed and discussed as they pertained to the following categories of CRS and sleep: (1) subjective measures of sleep dysfunction, (2) objective measures of sleep dysfunction, and (3) outcomes on sleep quality following treatment of CRS. Articles on the pathophysiology of sleep dysfunction in CRS were separately reviewed.ConclusionsAn evolving body of research demonstrates that quality of sleep is compromised in the majority of patients with CRS. Following treatment of CRS, there is significant improvement in subjective sleep quality, but additional research investigating objective measures following treatment is still needed. Additionally, further investigation is required to better elucidate the underlying pathophysiology of the relationship between sleep dysfunction and CRS.Level of EvidenceN/A.
Ultrafiltration Membranes Functionalized with Polydopamine with Enhanced Contaminant Removal by Adsorption
Authors: Capozzi Luigi C. , Mehmood Farrukh M. , Giagnorio Mattia , Tiraferri Alberto , Cerruti Marta , Sangermano Marco 
Published: February 2017

The performance of polymeric ultrafiltration membranes functionalized with polydopamine to couple depth adsorption of contaminants with the typical surface rejection characteristics of the membrane is investigated. Two approaches are deployed to achieve this functionalization: in a two‐step method, the ultrafiltration membranes are initially fabricated by phase inversion, then followed by coating with polydopamine; in a more facile and advantageous one‐step method, the membranes are subjected to phase inversion in a water solution containing dopamine, so that polymer precipitation and polydopamine functionalization occur at the same time. Methylene blue is used as the representative target contaminant to study the enhancement of membrane adsorption behavior, and its removal is investigated both in batch and under filtration conditions. The sorption capacity increases with increasing polydopamine coating time and is higher for the membranes fabricated via the one‐step protocol. The amount of methylene blue adsorbed per unit of membrane mass is large (roughly 5–10 mg g−1) and the kinetics of adsorption is fast. These characteristics allow these materials to get operated effectively and for long times in membrane filtration processes before stopping the system for regeneration. The saturated membranes are completely regenerated and reused without loss of performance by cycling in acidic and alkaline solutions.
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Nonmigrating Equivalent Substitutes for PVC/DOP Formulations as Shown by a TG Study of PVC with Covalently Bound PEO–PPO Oligomers
Authors: Navarro Rodrigo , Gacal Tülin , Ocakoglu Melike , García Carolina , Elvira Carlos , Gallardo Alberto , Reinecke Helmut 
Published: February 2017

Monoamino functionalized ethylenoxide (EO)/propylenoxide oligomers (Jeffamine) are linked chemically to poly(vinyl chloride) (PVC) using trichlorotriazine chemistry in order to prepare nonmigrating internally plasticized materials. The dependence of the plasticizer efficiency on both the number of anchoring points to the chains and the PVC/plasticizer compatibility is investigated using oligomers of different molecular weight and hydrophilic–hydrophobic balance. Hydrophilic oligomers (containing predominantly EO) of molecular weights between 2000 and 5000 g mol−1 exhibit excellent plasticizer efficiency, nearly identical to di‐2‐ethylhexylphthalate (DOP) in conventional PVC/DOP mixtures and may therefore be used as nonmigrating equivalents for DOP.
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Analysis of the roles of dietary protein and calcium in fluoride‐induced changes in T‐lymphocyte subsets in rat
Authors: Wang Hongwei , Zhou Bianhua , Niu Ruiyan , Wang Jinming , Zhang Jianhai , Wang Jundong 
Published: February 2017

AbstractThe roles of dietary protein (Pr) and calcium (Ca) levels on the changes in T‐lymphocyte subsets induced by excessive fluoride (F) intake were assessed using rats that were malnourished for 120 days as a model. The CD4+ and CD8+ T‐lymphocytes in the spleen tissue were determined by flow cytometry and immunofluorescence assay. The percentages of CD3+, CD4+, and CD8+ T‐lymphocytes were reduced in the spleen of rats exposed to excessive F, and malnutrition aggravated these changes in the T‐lymphocytes. In addition, the mRNA expression levels of IL‐1β, IL‐2, IL‐6, TNF‐α, and IFN‐γ in the spleen were downregulated significantly. We also reported herein the increased apoptosis ratio following caspase‐9 and caspase‐3 upregulation in the spleen of rats exposed to excessive amount of F. Light and transmisison electron microscopy revealed the irregularly arranged lymphocytes, few lymph nodules and the apoptotic characteristic of lymphocytes, which are caused by the increased expression of caspase. In addition, Pr and Ca supplementation reversed the morphologic and T‐lymphocytic changes in spleen under malnutrition. Taken together, our results revealed an endogenous caspase‐mediated mechanism of regulating the apoptosis of the T‐lymphocyte subsets, as well as the immune‐related cytokine secretion, which reduces the immune function in F‐induced rats. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1587–1595, 2017.
Representation of speech variability
Authors: Bent Tessa , Holt Rachael F. 
Published: February 2017

Speech signals provide both linguistic information (e.g., words and sentences) as well as information about the speaker who produced the message (i.e., social‐indexical information). Listeners store highly detailed representations of these speech signals, which are simultaneously indexed with linguistic and social category membership. A variety of methodologies—forced‐choice categorization, rating, and free classification—have shed light on listeners’ cognitive‐perceptual representations of the social‐indexical information present in the speech signal. Specifically, listeners can accurately identify some talker characteristics, including native language status, approximate age, sex, and gender. Additionally, listeners have sensitivity to other speaker characteristics—such as sexual orientation, regional dialect, native language for non‐native speakers, race, and ethnicity—but listeners tend to be less accurate or more variable at categorizing or rating speakers based on these constructs. However, studies have not necessarily incorporated more recent conceptions of these constructs (e.g., separating listeners’ perceptions of race vs ethnicity) or speakers who do not fit squarely into specific categories (e.g., for sex perception, intersex individuals; for gender perception, genderqueer speakers; for race perception, multiracial speakers). Additional research on how the intersections of social‐indexical categories influence speech perception is also needed. As the field moves forward, scholars from a variety of disciplines should be incorporated into investigations of how listeners’ extract and represent facets of personal identity from speech. Further, the impact of these representations on our interactions with one another in contexts outside of the laboratory should continue to be explored. WIREs Cogn Sci 2017, 8:e1434. doi: 10.1002/wcs.1434This article is categorized under:

Linguistics > Language Acquisition
Linguistics > Language in Mind and Brain
Psychology > Language
Fine‐Needle Aspiration Cytology (FNAC) in Breast Cancer: A Reappraisal Based on Retrospective Review of 698 Cases
Authors: Kazi Mufaddal , Suhani  , Parshad Rajinder , Seenu V. , Mathur Sandeep , Haresh K. P. 
Published: February 2017

AbstractBackgroundCore needle biopsy is replacing fine‐needle aspiration cytology (FNAC) as the modality of choice for breast cancer diagnosis. This study was carried out to determine the usefulness of FNAC in breast cancer patients in a tertiary care center in North India.MethodsCase files of patients managed in the breast cancer clinic of a single surgical unit between 1993 and 2014 were reviewed. All patients who underwent FNAC at our institute or had their slides reviewed at our institute were included in the study. Patients operated on outside our center and those with FNAC reports which were not available for review were excluded. Data were entered in Microsoft Excel and analyzed with SPSS version 21. True positives and false negatives for FNAC were noted from which sensitivities and positive predictive values (PPVs) were calculated.ResultsFNAC was performed in 698 of 1310 patients. Mean age was 48.3 years. There were 9 (1.3%) male breast cancer patients. 696 (99.7%) patients had a palpable lump with a mean tumor size of 5.3 cm. 54.2% of the patients were clinically node positive. While over 80% of patients were diagnosed on the basis of FNAC before 2000, less than 50% of the patients had an FNAC after 2010. FNAC diagnosed malignancy in 627 patients, while it was inconclusive in 69 and false negative in two patients. No false‐positive results were seen. These figures yield an absolute sensitivity of 89.8% and a complete sensitivity of 99.7% for FNAC with a 100% PPV.ConclusionsFNAC is a reliable tool for diagnosing cancer in suspicious breast lesions with a good sensitivity and PPV in hands of an experienced cytopathologist. Surgical treatment may be safely undertaken based on FNAC particularly in early operable breast cancers suitable for breast conservation.
A single session of repetitive transcranial magnetic stimulation of the prefrontal cortex reduces cue-induced craving in patients with gambling disorder
Authors: Gay A. , Boutet C. , Sigaud T. , Kamgoue A. , Sevos J. , Brunelin J. , Massoubre C. 
Published: February 2017

AbstractBackgroundGambling disorder (GD) is common and disabling addictive disorder. In patients with substance use disorders, the application of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) offers promise to alleviate craving. We hypothesized that applying real compared to sham rTMS over the left DLPFC would reduce gambling craving in patients with GD.MethodsIn a randomized sham-controlled crossover design, 22 treatment-seeking patients with GD received real or sham treatment with high frequency rTMS over the left DLPFC followed a week later by the other type of treatment. Before and after each rTMS session, participants rated their gambling craving (from 0 to 100) before and after viewing a gambling video used as a cue. We used the Yale-Brown Obsessive Compulsive Scale adapted for Pathological Gambling to assess gambling behavior before and 7 days after each rTMS session.ResultsAs compared to sham (mean +0.74; standard deviation ± 3.03), real rTMS significantly decreased cue-induced craving (−2.12 ± 3.39;F(1,19)= 4.87;P= 0.04; partialη2= 0.05; 95% CI: 0.00–0.21). No significant effect of rTMS was observed on gambling behavior.ConclusionsPatients with GD reported decreased cue-induced craving following a single session of high frequency rTMS applied over the left DLPFC. Further large randomized controlled studies are needed to determine the usefulness of rTMS in GD.
The personal presence of Jesus in the writings of Paul
Authors: Bockmuehl Markus 
Published: February 2017

AbstractFor Paul, where is Jesus now? The Apostle's Christ-mysticism provides one important clue to his sense of continued personal presence, but this coexists with an important eschatological dialectic that involves absence as much as presence. Moreoever, straightforward sublimation in terms of the Holy Spirit in no way exhausts the register of Jesus’ personal presence for Paul, which also finds specific application in repeated visionary experiences, as well as in the church gathered for worship, baptism, and eucharist. The dialectic of absence and presence appears on the one hand personally attuned in the assurance of Paul's Jesus that ‘My grace is sufficient for you’ (2 Cor 12:7), but it is also eschatologically and spatially articulated in the promise that ‘the Lord is near’ (Phil 4:5).
Configural and Featural Face Processing Influences on Emotion Recognition in Schizophrenia and Bipolar Disorder
Authors: Van Rheenen Tamsyn E. , Joshua Nicole , Castle David J , Rossell Susan L. 
Published: February 2017

AbstractObjectives: Emotion recognition impairments have been demonstrated in schizophrenia (Sz), but are less consistent and lesser in magnitude in bipolar disorder (BD). This may be related to the extent to which different face processing strategies are engaged during emotion recognition in each of these disorders. We recently showed that Sz patients had impairments in the use of both featural and configural face processing strategies, whereas BD patients were impaired only in the use of the latter. Here we examine the influence that these impairments have on facial emotion recognition in these cohorts. Methods: Twenty-eight individuals with Sz, 28 individuals with BD, and 28 healthy controls completed a facial emotion labeling task with two conditions designed to separate the use of featural and configural face processing strategies; part-based and whole-face emotion recognition. Results: Sz patients performed worse than controls on both conditions, and worse than BD patients on the whole-face condition. BD patients performed worse than controls on the whole-face condition only. Conclusions: Configural processing deficits appear to influence the recognition of facial emotions in BD, whereas both configural and featural processing abnormalities impair emotion recognition in Sz. This may explain discrepancies in the profiles of emotion recognition between the disorders. (JINS, 2017, 23, 287–291)
Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species
Authors: González-Lizárraga Florencia , Socías Sergio B. , Ávila César L. , Torres-Bugeau Clarisa M. , Barbosa Leandro R. S. , Binolfi Andres , Sepúlveda-Díaz Julia E. , Del-Bel Elaine , Fernandez Claudio O. , Papy-Garcia Dulce , Itri Rosangela , Raisman-Vozari Rita , Chehín Rosana N. 
Published: February 2017

AbstractSynucleinophaties are progressive neurodegenerative disorders with no cure to date. An attractive strategy to tackle this problem is repurposing already tested safe drugs against novel targets. In this way, doxycycline prevents neurodegeneration in Parkinson models by modulating neuroinflammation. However, anti-inflammatory therapy per se is insufficient to account for neuroprotection. Herein we characterise novel targets of doxycycline describing the structural background supporting its effectiveness as a neuroprotector at subantibiotic doses. Our results show that doxycycline reshapes α-synuclein oligomers into off-pathway, high-molecular-weight species that do not evolve into fibrils. Off-pathway species present less hydrophobic surface than on-pathway oligomers and display different β-sheet structural arrangement. These structural changes affect the α-synuclein ability to destabilize biological membranes, cell viability, and formation of additional toxic species. Altogether, these mechanisms could act synergically giving novel targets for repurposing this drug.
The citrus flavanone naringenin impairs dengue virus replication in human cells
Authors: Frabasile Sandra , Koishi Andrea Cristine , Kuczera Diogo , Silveira Guilherme Ferreira , Verri Waldiceu Aparecido , Duarte dos Santos Claudia Nunes , Bordignon Juliano 
Published: February 2017

AbstractDengue is one of the most significant health problems in tropical and sub-tropical regions throughout the world. Nearly 390 million cases are reported each year. Although a vaccine was recently approved in certain countries, an anti-dengue virus drug is still needed. Fruits and vegetables may be sources of compounds with medicinal properties, such as flavonoids. This study demonstrates the anti-dengue virus activity of the citrus flavanone naringenin, a class of flavonoid. Naringenin prevented infection with four dengue virus serotypes in Huh7.5 cells. Additionally, experiments employing subgenomic RepDV-1 and RepDV-3 replicon systems confirmed the ability of naringenin to inhibit dengue virus replication. Antiviral activity was observed even when naringenin was used to treat Huh7.5 cells 24 h after dengue virus exposure. Finally, naringenin anti-dengue virus activity was demonstrated in primary human monocytes infected with dengue virus sertoype-4, supporting the potential use of naringenin to control dengue virus replication. In conclusion, naringenin is a suitable candidate molecule for the development of specific dengue virus treatments.
Longitudinal in vivo bioimaging of hepatocyte transcription factor activity following cholestatic liver injury in mice
Authors: Delhove Juliette M. K. M. , Buckley Suzanne M. K. , Perocheau Dany P. , Karda Rajvinder , Arbuthnot Patrick , Henderson Neil C. , Waddington Simon N. , McKay Tristan R. 
Published: February 2017

AbstractMolecular mechanisms regulating liver repair following cholestatic injury remain largely unknown. We have combined a mouse model of acute cholestatic liver injury, partial bile duct ligation (pBDL), with a novel longitudinal bioimaging methodology to quantify transcription factor activity during hepatic injury and repair. We administered lentiviral transcription factor activated luciferase/eGFP reporter (TFAR) cassettes to neonatal mice enabling longitudinal TFAR profiling by continued bioimaging throughout the lives of the animals and following pBDL in adulthood. Neonatal intravascular injection of VSV-G pseudotyped lentivirus resulted in almost exclusive transduction of hepatocytes allowing analysis of hepatocyte-specific transcription factor activity. We recorded acute but transient responses with NF-κB and Smad2/3 TFAR whilst our Notch reporter was repressed over the 40 days of evaluation post-pBDL. The bipotent hepatic progenitor cell line, HepaRG, can be directed to differentiate into hepatocytes and biliary epithelia. We found that forced expression of the Notch inhibitor NUMB in HepaRG resulted in enhanced hepatocyte differentiation and proliferation whereas over-expressing the Notch agonist JAG1 resulted in biliary epithelial differentiation. In conclusion, our data demonstrates that hepatocytes rapidly upregulate NF-κB and Smad2/3 activity, whilst repressing Notch signalling. This transcriptional response to cholestatic liver injury likely promotes partial de-differentiation to allow pro-regenerative proliferation of hepatocytes.
Outcome and Treatment of Nocardiosis After Solid Organ Transplantation: New Insights From a European Study
Authors: Lebeaux David , Freund Romain , van Delden Christian , Guillot Hélène , Marbus Sierk D. , Matignon Marie , Van Wijngaerden Eric , Douvry Benoit , De Greef Julien , Vuotto Fanny , Tricot Leïla , Fernández-Ruiz Mario , Dantal Jacques , Hirzel Cédric , Jais Jean-Philippe , Rodriguez-Nava Veronica , Jacobs Frédérique , Lortholary Olivier , Coussement Julien ,   for the European Study Group for Nocardia in Solid Organ Transplantation, Anstey James R. , Antoine Martine , Ausselet Nathalie , Belhaj Asmae , Boelens Jerina , de Beenhouwer Hans , Denis Catherine , Ho Erwin , Ieven Margareta , Jonckheere Stijn , Knoop Christiane , le Moine Alain , Rodriguez-Villalobos Hector , Racapé Judith , Roisin Sandrine , Vandercam Bernard , Vander Zwalmen Marie-Laure , Vanfraechem Gaëlle , Van Laecke Steven , Verhaegen Jan , Barrou Benoit , Battistella Pascal , Bergeron Emmanuelle , Bouvier Nicolas , Caillard Sophie , Caumes Eric , Chaussade Hélène , Chauvet Cécile , Crochette Romain , Epailly Eric , Essig Marie , Gallien Sébastien , Guillemain Romain , Herel Canan , Hoen Bruno , Kamar Nassim , le Gall Thierry , Levi Charlene , Lionet Arnaud , Longuet Hélène , Melica Giovanna , Miel Anaick , Morel Hélène , Ammar Salima Ould , Pattier Sabine , Peraldi Marie-Noelle , Sayegh Johnny , Scemla Anne , Senechal Agathe , Tourret Jérome , Boggian Katia , Egli Adrian , Garzoni Christian , Hoffman Matthias , Hirsch Hans H. , Khanna Nina , Manuel Oriol , Meylan Pascal , Mueller Nicolas J. , Posfay-Barbe Klara M. , Vu Diem-Lan , Weisser Maja , Vollaard Albert M. , Wunderink Herman F. 
Published: February 2017

Summary
In our study of 117 organ transplant recipients with nocardiosis, a history of tumor, invasive fungal infection, donor age, and no acute rejection were independently associated with 1-year mortality. Short-course antibiotic treatment (≤120 days), used in 17 patients, appeared promising.
Should Human Immunodeficiency Virus Specialty Clinics Treat Patients With Hypertension or Refer to Primary Care? An Analysis of Treatment Outcomes
Authors: Appenheimer A. Ben , Bokhour Barbara , McInnes D. Keith , Richardson Kelly K. , Thurman Andrew L. , Beck Brice F. , Vaughan-Sarrazin Mary , Asch Steven M. , Midboe Amanda M. , Taylor Thom , Dvorin Kelly , Gifford Allen L. , Ohl Michael E. 
Published: February 2017

Abstract

Background
Care for people with human immunodeficiency virus (HIV) increasingly focuses on comorbidities, including hypertension. Evidence indicates that antiretroviral therapy and opportunistic infections are best managed by providers experienced in HIV medicine, but it is unclear how to structure comorbidity care. Approaches include providing comorbidity care in HIV clinics (“consolidated care”) or combining HIV care with comorbidity management in primary care clinics (“shared care”). We compared blood pressure (BP) control in HIV clinics practicing consolidated care versus shared care.

Methods
We created a national cohort of Veterans with HIV and hypertension receiving care in HIV clinics in Veterans Administration facilities and merged these data with a survey asking HIV providers how they delivered hypertension care (5794 Veterans in 73 clinics). We defined BP control as BP ≤140/90 mmHg on the most recent measure. We compared patients’ likelihood of experiencing BP control in clinics offering consolidated versus shared care, adjusting for patient and clinic characteristics.

Results
Forty-two of 73 clinics (57.5%) practiced consolidated care for hypertension. These clinics were larger and more likely to use multidisciplinary teams. The unadjusted frequency of BP control was 65.6% in consolidated care clinics vs 59.4% in shared care clinics (P &lt; .01). The likelihood of BP control remained higher for patients in consolidated care clinics after adjusting for patient and clinic characteristics (odds ratio, 1.32; 95% confidence interval, 1.04–1.68).

Conclusions
Patients were more likely to experience BP control in clinics reporting consolidated care compared with clinics reporting shared care. For shared-care clinics, improving care coordination between HIV and primary care clinics may improve outcomes.