bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase-Transition Nanodroplets for Real-Time Photoacoustic/Ultrasound Dual-Modality Imaging and Photothermal Therapy of Sentinel Lymph Node in Breast Cancer
Authors: Yang Lu , Cheng Juan , Chen Yuli , Yu Shengjie , Liu Fengqiu , Sun Yang , Chen Yu , Ran Haitao 
Published: March 2017

AbstractPathological status of lymph nodes (LNs) plays a critical role in staging and treatment for the patients with breast cancer. Sentinel lymph node biopsy has become the standard method in determining pathological status of axillary LNs. Therefore, the determination of sentinel lymph nodes (SLNs) and therapy of metastatic LNs are highly desirable in clinic. Herein, an unprecedented carbon nanoparticles (CNs)-incorporated liquid-gas phase-transition nanodroplets (CNPs) with strong near-infrared (NIR) absorption, good biocompatibility, excellent photoacoustic (PA) and ultrasound (US) contrast, and high photothermal-conversion efficiency are reported in this study. Upon laser irradiation, liquid-gas phase transition of the CNPs has been demonstrated to provide excellent contrasts for PA/US dual-modality imaging both in vitro and in vivo. Additionally, the CNPs are capable of staining lymph nodes, which can contribute significantly to the identification of LNs with naked eyes. With increased laser energy, the CNPs exhibit the high performance in killing the breast cancer cells both in vitro and in vivo, due to the photothermal effect induced from the CNs within CNPs. These results suggest that the developed multifunctional phase-transition nanodroplets have high potential to act as the theranostic agents in both SLNs detection and therapy of metastatic LNs.
Simultaneous treatment of temporomandibular joint ankylosis with severe mandibular deficiency by standard TMJ prosthesis
Authors: Hu YiHui , Zhang LuZhu , He DongMei , Yang Chi , Chen MinJie , Zhang ShanYong , Li Hui , Ellis III Edward 
Published: March 2017

AbstractTemporomandibular joint (TMJ) ankylosis is a refractory disease that is difficult to predictably treat. This study evaluated the prognosis of using standard alloplastic TMJ prostheses for the treatment of TMJ ankylosis in Chinese patients with severe mandibular deficiency. Patients treated from 2013 to 2015 were reviewed. The computer-aided design and manufacture (CAD/CAM) technique was used to guide bony mass removal and locate the TMJ prosthesis (Biomet, USA). Eleven patients were included in this study. All prostheses were successfully installed and stabilized intraoperatively. In 4 patients with severe mandibular deficiency, their mandibular ramus was elongated by the TMJ prosthesis and 2 patients were combined with Le Fort I osteotomy guided by digital templates. Their mean chin advancement was 10.19 mm. Their SNB and ramus heights were also significantly improved after operation (P < 0.05). There was no prosthesis loosening, breakage, or infection leading to removal after a mean follow-up period of 22 months (range, 12-31mos.). Mouth opening was significantly improved from 5.5 mm preoperatively to 31.5 mm postoperatively. TMJ reconstruction with standard alloplastic prosthesis is a reliable treatment for ankylosis, especially in recurrent cases. By CAD/CAM technique, it can correct jaw deformities simultaneously and produce stable results.
Ambulatory Voice Biofeedback: Relative Frequency and Summary Feedback Effects on Performance and Retention of Reduced Vocal Intensity in the Daily Lives of Participants With Normal Voices
Authors: Van Stan Jarrad H. , Mehta Daryush D. , Sternad Dagmar , Petit Robert , Hillman Robert E. 
Published: March 2017

PurposeAmbulatory voice biofeedback has the potential to significantly improve voice therapy effectiveness by targeting carryover of desired behaviors outside the therapy session (i.e., retention). This study applies motor learning concepts (reduced frequency and delayed, summary feedback) that demonstrate increased retention to ambulatory voice monitoring for training nurses to talk softer during work hours.MethodForty-eight nurses with normal voices wore the Voice Health Monitor (Mehta, Zañartu, Feng, Cheyne, & Hillman, 2012) for 6 days: 3 baseline days, 1 biofeedback day, 1 short-term retention day, and 1 long-term retention day. Participants were block-randomized into 3 different biofeedback groups: 100%, 25%, and Summary. Performance was measured in terms of compliance time below a participant-specific vocal intensity threshold.ResultsAll participants exhibited a significant increase in compliance time (Cohen'sd= 4.5) during biofeedback days compared with baseline days. The Summary feedback group exhibited statistically smaller performance reduction during both short-term (d= 1.14) and long-term (d= 1.04) retention days compared with the 100% feedback group.ConclusionsThese findings suggest that modifications in feedback frequency and timing affect retention of a modified vocal behavior in daily life. Future work calls for studying the potential beneficial impact of ambulatory voice biofeedback in participants with behaviorally based voice disorders.
Origin of the wide-orbit circumbinary giant planet HD 106906
Authors: Rodet L. , Beust H. , Bonnefoy M. , Lagrange A.-M. , Galli P. A. B. , Ducourant C. , Teixeira R. 
Published: March 2017

Context. A giant planet has been recently resolved at a projected distance of 730 au from the tight pair of young (~13 Myr) intermediate-mass stars HD 106906AB in the Lower Centaurus Crux (LCC) group. The stars are surrounded by a debris disk which displays a ring-like morphology and strong asymmetries at multiple scales.
Aims. We aim to study the likelihood of a scenario where the planet formed closer to the stars in the disk, underwent inward disk-induced migration, and got scattered away by the binary star before being stabilized by a close encounter (fly-by).
Methods. We performed semi-analytical calculations and numerical simulations (Swift_HJS package) to model the interactions between the planet and the two stars. We accounted for the migration as a simple force. We studied the LCC kinematics to set constraints on the local density of stars, and therefore on the fly-by likelihood. We performed N-body simulations to determine the effects of the planet trajectories (ejection and secular effects) onto the disk morphology.
Results. The combination of the migration and mean-motion resonances with the binary star (often 1:6) can eject the planet. Nonetheless, we estimate that the fly-by hypothesis decreases the scenario probability to less than 10-7 for a derived local density of stars of 0.11 stars/pc3. We show that the concomitant effect of the planet and stars trajectories induce spiral-features in the disk which may correspond to the observed asymmetries. Moreover, the present disk shape suggests that the planet is on an eccentric orbit.
Conclusions. The scenario we explored is a natural hypothesis if the planet formed within a disk. Conversely, its low probability of occurrence and the fact that HD 106906 b shares some characteristics with other systems in Sco-Cen (e.g., HIP 78530, in terms of mass ratio and separation) may indicate an alternative formation pathway for those objects.
The politics of recognition, and the manufacturing of citizenship and identity in Senegal’s decentralised charcoal market
Authors: Faye Papa 
Published: March 2017

ABSTRACT
This article shows how state politics of (re)allocation of rights and resources to social groups within a society (recognition) are constructive of distinct abilities to shape the fate of the political economy of natural resources (citizenship) and of specific images of self (identities). It departs from the politics of recognition applied by the Forest Service to private merchants and forest villagers in Eastern Senegal. Herein, I theorise citizenship and identity as effects of the politics of recognition and redistribution, emphasising that identities are culturally bounded categories, but are also products (through reclassification) of public institutions’ discourses, legal ordinances and practices.
Final report on CCQM-K125: elements in infant formula
Authors: Merrick J , Saxby D , Dutra E S , Sena R C , Araújo T O , Almeida M D , Yang L , Pihillagawa I G , Mester Z , Sandoval S , Wei C , Castillo M E D , Oster C , Fisicaro P , Rienitz O , Pape C , Schulz U , Jährling R , Görlitz V , Lampi E , Kakoulides E , Sin D W M , Yip Y C , Tsoi Y T , Zhu Y , Okumu T O , Yim Y H , Heo S W , Han M , Lim Y , Osuna M A , Regalado L , Uribe C , Buzoianu M M , Duta S , Konopelko L , Krylov A , Shin R , Linsky M , Botha A , Magnusson B , Haraldsson C , Thiengmanee U , Klich H , Can S Z , Coskun F G , Tunc M , Entwisle J , O'Reilly J , Hill S , Goenaga-Infante H , Winchester M , Rabb S A , Pérez R 
Published: March 2017

CCQM-K125 was organized by the Inorganic Analysis Working Group (IAWG) of CCQM to assess and document the capabilities of the national metrology institutes (NMIs) or the designated institutes (DIs) to measure the mass fractions of trace elements (K, Cu and I) in infant formula. Government Laboratory, Hong Kong SAR (GLHK) acted as the coordinating laboratory.
In CCQM-K125, 25 institutes submitted the results for potassium, 24 institutes submitted the results for copper and 8 institutes submitted the results for iodine.
For examination of potassium and copper, most of the participants used microwave-assisted acid digestion methods for sample dissolution. A variety of instrumental techniques including inductively coupled plasma mass spectrometry (ICP-MS), isotope dilution inductively coupled plasma mass spectrometry (ID-ICP-MS), inductively coupled plasma optical emission spectrometry (ICP-OES), atomic absorption spectrometry (AAS), flame atomic emission spectrometry (FAES) and microwave plasma atomic emission spectroscopy (MP-AES) were employed by the participants for determination. For analysis of iodine, most of the participants used alkaline extraction methods for sample preparation. ICP-MS and ID-ICP-MS were used by the participants for the determination.
Generally, the participants' results of CCQM-K125 were found consistent for all measurands according to their equivalence statements. Except with some extreme values, most of the participants obtained the values of di
/U(di
) within ± 1 for the measurands.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Anticipated Changes in Spine Practice with Advancing Center for Medicare and Medicaid Services-Required Changes
Authors: Swartz Karin R. , Cheng Joseph S. 
Published: March 2017

Abstract
In providing spinal care to neurosurgical patients, cost and quality metrics are areas of interest to many. The federal government has legislated changes mandated for Centers for Medicare and Medicaid Services-enrolled patient care. The ever-changing administrative and patient-care challenges and opportunities are explored in this article, highlighting the Medicare Access and CHIP (Children's Health Insurance Program) Reauthorization Act of 2015 (MACRA), in the context of the Affordable Care Act. Trends in contemporary spinal care, addressing bundling, patient satisfaction, and ambulatory surgical centers are featured.
Macrovascular Decompression of the Brainstem and Cranial Nerves: Evolution of an Anteromedial Vertebrobasilar Artery Transposition Technique
Authors: Choudhri Omar , Connolly Ian D. , Lawton Michael T. 
Published: March 2017

Abstract

BACKGROUND: Tortuous and dolichoectatic vertebrobasilar arteries can impinge on the brainstem and cranial nerves to cause compression syndromes. Transposition techniques are often required to decompress the brainstem with dolichoectatic pathology. We describe our evolution of an anteromedial transposition technique and its efficacy in decompressing the brainstem and relieving symptoms.

OBJECTIVE: To present the anteromedial vertebrobasilar artery transposition technique for macrovascular decompression of the brainstem and cranial nerves.

METHODS: All patients who underwent vertebrobasilar artery transposition were identified from the prospectively maintained database of the Vascular Neurosurgery service, and their medical records were reviewed retrospectively. The extent of arterial displacement was measured pre- and postoperatively on imaging.

RESULTS: Vertebrobasilar arterial transposition and macrovascular decompression was performed in 12 patients. Evolution in technique was characterized by gradual preference for the far-lateral approach, use of a sling technique with muslin wrap, and an anteromedial direction of pull on the vertebrobasilar artery with clip-assisted tethering to the clival dura. With this technique, mean lateral displacement decreased from 6.6 mm in the first half of the series to 3.8 mm in the last half of the series, and mean anterior displacement increased from 0.8 to 2.5 mm, with corresponding increases in satisfaction and relief of symptoms.

CONCLUSION: Compressive dolichoectatic pathology directed laterally into cranial nerves and posteriorly into the brainstem can be corrected with anteromedial transposition towards the clivus. Our technique accomplishes this anteromedial transposition from an inferolateral surgical approach through the vagoaccessory triangle, with sling fixation to clival dura using aneurysm clips.
Asthma prevalence and severity in low-resource communities
Authors: Cruz Álvaro A. , Stelmach Rafael , Ponte Eduardo V. 
Published: March 2017

Purpose of review
The prevalence of asthma was thought to be low in most low-income countries, but several reports have indicated this is not always true. This is a narrative review of recent publications on the burden of asthma in low and middle-income countries (LMIC) and underprivileged communities from developed countries.

Recent findings
Several studies have reported a low prevalence of asthma is LMIC, but indicate it is increasing. In the last few years, however, many surveys demonstrated this may not always be true. An analysis of the International Study for Asthma and Allergy in Childhood phase III database indicated although the prevalence of asthma among children and adolescents is higher in the developed countries, symptoms of asthma are often more severe in less affluent nations. The rate of uncontrolled asthma is also higher among underprivileged communities of developed countries. Secondary analysis of data generated by the WHO's world health survey performed among adults of 70 countries indicate symptoms of asthma are less frequent in middle-income countries and more frequent in the extremes, low income and high income. This sort of U shaped distribution suggests the disease (or syndrome) comprise more than one major phenotype related to diverse underlying mechanisms. In fact, recent reports show symptoms of asthma among the poor are associated with unhygienic living conditions, which may reduce the risk of atopy but increase the risk of nonatopic wheezing. Urbanization and exposure to air pollution also seem to contribute to an increasing prevalence severity of asthma in LMIC. Access to proper diagnosis and treatment with controller medications for asthma, specially with inhaled corticosteroids is feasible and cost-effective, reduce symptoms, health resource utilization, improves quality of life, and reduce mortality in low-resource settings.

Summary
Prevalence of asthma was thought to be low in low-income countries, but several reports have indicated this is not always true. Under diagnosis, under treatment, exposure to air pollution, and unhygienic living conditions may contribute to a higher frequency and severity of symptoms of asthma among the poor. Proper diagnosis and treatment with controller medications for asthma is feasible and cost-effective in low-resource settings.
CONTRALATERAL VISION LOSS AFTER ENDONASAL DACRYOCYSTORHINOSTOMY: A CASE REPORT OF PURTSCHER-LIKE RETINOPATHY AND TREATMENT WITH INTRAVITREAL TISSUE PLASMINOGEN ACTIVATOR
Authors: Gungel Hulya , Altan Cigdem , Karini Belma , Ozdemir Fatma E. , Celebi Ozlem O. 
Published: March 2017

Purpose:
To present a case of a patient with contralateral vision loss as a result of Purtscher-like retinopathy after an endonasal dacryocystorhinostomy and treatment with intravitreal tissue plasminogen activator injection.

Methods and Results:
A 51-year-old woman who underwent a left endonasal dacryocystorhinostomy was referred with a complaint of decreased vision 1 day after surgery in her right eye. At the initial examination, the visual acuity of her right eye was hand motion. The fundoscopic examination revealed a premacular hemorrhage, diffuse intraretinal hemorrhages, multiple peripapillary cotton wool patches, and Purtscher flecken. The patient received 50 μg/0.1 mL of intravitreal tissue plasminogen activator injection. One day after the injection, visual acuity improved to 3/20. On 1-month follow-up without medication, the visual acuity improved to 6/20, and normal visual evoked potential latencies and amplitudes were detected.

Conclusion:
Purtscher- like retinopathy may occur as a complication of endonasal dacryocystorhinostomy. Intravitreal tissue plasminogen activator may help relieve the embolization that occurs in Purtscher-like retinopathy.
Midazolam as an active placebo in 3 fentanyl-validated nociceptive pain models
Authors: Prosenz Julian , Gustorff Burkhard 
Published: March 2017

Abstract
The use of inactive placebos in early translational trials of potentially analgesic compounds is discouraged because of the side-effect profiles of centrally acting analgesics. Therefore, benzodiazepines are used, although their use has not been validated in this context. Whether benzodiazepines confound the results of acute pain tests is unknown. Midazolam (0.06 mg/kg) as an active placebo was investigated in 3 nociceptive models that included contact heat, electrical pain, and pressure pain thresholds in 24 healthy volunteers. Fentanyl (1 μg/kg) served as an internal validator in this randomized, placebo (saline) controlled, 3-way cross-over trial. The primary outcome parameter (contact heat pain) was analyzed using a one-way, repeated measures analysis of variance and Tukey's post test. Midazolam did not reduce pain ([numeric rating scale], 0-100) in a statistically significant manner compared with placebo for the contact heat (mean difference −1.7, 95% confidence interval −10.6 to 7.3; P = 0.89) or electrical pain (4.3, −5.1 to 13.7; P = 0.51) test, nor did it raise the pressure pain thresholds (−28 kPa, −122; 64 kPa, P = 0.73). The width of the confidence intervals suggested that there were no clinically meaningful analgesic effects compared with the placebo. In contrast, the analgesic efficacy of fentanyl was effectively demonstrated in all 3 models (P < 0.01 vs midazolam and placebo). The findings of this study show that midazolam can be used as an active placebo in analgesic drug trials. Furthermore, the proposed models were simple to implement and very effective in detecting analgesia. The test battery can be used in translational trials for new compounds and comes with an active placebo and an optional active comparator.
Associations Between Medication Class and Subsequent Augmentation of Depression Treatment in Privately Insured US Adults
Authors: Ameli Omid , Soria-Saucedo Rene , Smith Eric G. , Cabral Howard J. , Soley-Bori Marina , Kazis Lewis E. 
Published: March 2017

Abstract

Importance
Treatment augmentation is an important clinical decision in the pharmacotherapy for depression, yet few studies have examined the rates of treatment augmentation by medication class.

Objective
The aim of this study was to examine which initial pharmacotherapies for depression are more likely than others to result in subsequent treatment augmentation.

Methods
This study is a retrospective cohort analysis of administrative data of 214,705 privately insured US adults between the age of 18 and 64 years who were diagnosed with a new episode of depression in 2009. Propensity score–adjusted logistic regression and Cox regression were used to model the effect of the class of initial monotherapy on treatment augmentation. Risk adjustors included depression severity, comorbidities, provider type, insurance, and demographic characteristics.

Exposure
The class of initial monotherapy and the health care provider type were the main independent variables of interest.

Main Outcome
The outcome was the augmentation of monotherapy.

Results
Thirty-four percent of individuals received treatment augmentation. Compared with selective serotonin reuptake inhibitor monotherapy, second-generation antipsychotics as the initial treatment were associated with significant increase in the likelihood of augmentation compared with the other classes (hazards ratio, 2.59; 95% confidence interval [CI], 2.51–2.68). This result was corroborated after propensity score adjustment (odds ratio, 2.85; 95% CI, 2.70–3.00) when comparing second-generation antipsychotics to the other classes of pharmacotherapy. The other significant predictor of treatment augmentation was the provider type. Mental health specialists were 27% more likely to augment a treatment compared with generalists (hazards ratio, 1.27; 95% CI, 1.25–1.30).

Conclusions
The type of initial antidepressant therapy is associated with the chances of treatment augmentation. Second-generation antipsychotics progressed to augmentation more rapidly than the other classes.
Vertical Midface Lifting with Periorbital Anchoring in the Management of Lower Eyelid Retraction: A 10-Year Clinical Retrospective Study
Authors: Pascali Michele , Botti Chiara , Cervelli Valerio , Botti Giovanni 
Published: March 2017

Background:
Lower eyelid retraction can be the unfortunate result of aesthetic surgery, trauma, disease, or the aging processes. The purpose of this article is to assess whether midface lifting based on purely vertical repositioning constitutes an effective procedure for its correction.

Methods:
A retrospective study was carried out on 199 patients (311 eyelids) operated on between January of 2004 and January of 2014. The various causes of eyelid retraction in this population included cosmetic blepharoplasty (56.8 percent), involutional ectropion (23.1 percent), tumor resection (9.5 percent), facial nerve paralysis (8.5 percent), and trauma and related surgery (2 percent). The study was restricted exclusively to cases of moderate and severe lower eyelid retraction addressed by means of midface lifting. The mean follow-up time was 16.8 months. All of the patients were subjected to midface lifting with strengthening of the lateral canthus. A spacer graft was also used in 37.7 percent of the cases.

Results:
One hundred ninety-five patients (97.9 percent) displayed objective improvement of the eyelid retraction and a marked degree of improvement both in aesthetic terms and as regards the functional disorders reported. Only four patients (2 percent) presented complications such as needing another operation.

Conclusion:
Midface lifting based on purely vertical repositioning makes it possible to recruit a considerable amount of “new” skin at the lower eyelid, thus ensuring a decrease in vertical distraction and correct recovery of the height of the external lamellar plane.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, IV.