bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drosophila sensory cilia lacking MKS proteins exhibit striking defects in development but only subtle defects in adults
Authors: Pratt Metta B. , Titlow Joshua S. , Davis Ilan , Barker Amy R. , Dawe Helen R. , Raff Jordan W. , Roque Helio 
Published: August 2016

ABSTRACT
Cilia are conserved organelles that have important motility, sensory and signalling roles. The transition zone (TZ) at the base of the cilium is crucial for cilia function, and defects in several TZ proteins are associated with human congenital ciliopathies such as nephronophthisis (NPHP) and Meckel–Gruber syndrome (MKS). In several species, MKS and NPHP proteins form separate complexes that cooperate with Cep290 to assemble the TZ, but flies seem to lack core components of the NPHP module. We show that MKS proteins in flies are spatially separated from Cep290 at the TZ, and that flies mutant for individual MKS genes fail to recruit other MKS proteins to the TZ, whereas Cep290 seems to be recruited normally. Although there are abnormalities in microtubule and membrane organisation in developing MKS mutant cilia, these defects are less apparent in adults, where sensory cilia and sperm flagella seem to function quite normally. Thus, localising MKS proteins to the cilium or flagellum is not essential for viability or fertility in flies.
Prevention of muscle wasting and osteoporosis: the value of examining novel animal models
Authors: Reilly Beau D. , Franklin Craig E. 
Published: August 2016

ABSTRACTBone mass and skeletal muscle mass are controlled by factors such as genetics, diet and nutrition, growth factors and mechanical stimuli. Whereas increased mechanical loading of the musculoskeletal system stimulates an increase in the mass and strength of skeletal muscle and bone, reduced mechanical loading and disuse rapidly promote a decrease in musculoskeletal mass, strength and ultimately performance (i.e. muscle atrophy and osteoporosis). In stark contrast to artificially immobilised laboratory mammals, animals that experience natural, prolonged bouts of disuse and reduced mechanical loading, such as hibernating mammals and aestivating frogs, consistently exhibit limited or no change in musculoskeletal performance. What factors modulate skeletal muscle and bone mass, and what physiological and molecular mechanisms protect against losses of muscle and bone during dormancy and following arousal? Understanding the events that occur in different organisms that undergo natural periods of prolonged disuse and suffer negligible musculoskeletal deterioration could not only reveal novel regulatory factors but also might lead to new therapeutic options. Here, we review recent work from a diverse array of species that has revealed novel information regarding physiological and molecular mechanisms that dormant animals may use to conserve musculoskeletal mass despite prolonged inactivity. By highlighting some of the differences and similarities in musculoskeletal biology between vertebrates that experience disparate modes of dormancy, it is hoped that this Review will stimulate new insights and ideas for future studies regarding the regulation of atrophy and osteoporosis in both natural and clinical models of muscle and bone disuse.
The plasticity of extracellular fluid homeostasis in insects
Authors: Beyenbach Klaus W. 
Published: August 2016

ABSTRACTIn chemistry, the ratio of all dissolved solutes to the solution's volume yields the osmotic concentration. The present Review uses this chemical perspective to examine how insects deal with challenges to extracellular fluid (ECF) volume, solute content and osmotic concentration (pressure). Solute/volume plots of the ECF (hemolymph) reveal that insects tolerate large changes in all three of these ECF variables. Challenges beyond those tolerances may be ‘corrected’ or ‘compensated’. While a correction simply reverses the challenge, compensation accommodates the challenge with changes in the other two variables. Most insects osmoregulate by keeping ECF volume and osmotic concentration within a wide range of tolerance. Other insects osmoconform, allowing the ECF osmotic concentration to match the ambient osmotic concentration. Aphids are unique in handling solute and volume loads largely outside the ECF, in the lumen of the gut. This strategy may be related to the apparent absence of Malpighian tubules in aphids. Other insects can suspend ECF homeostasis altogether in order to survive extreme temperatures. Thus, ECF homeostasis in insects is highly dynamic and plastic, which may partly explain why insects remain the most successful class of animals in terms of both species number and biomass.
Dietary antioxidants and flight exercise in female birds affect allocation of nutrients to eggs: how carry-over effects work
Authors: Skrip Megan M. , Seeram Navindra P. , Yuan Tao , Ma Hang , McWilliams Scott R. 
Published: August 2016

ABSTRACTPhysiological challenges during one part of the annual cycle can carry over and affect performance at a subsequent phase, and antioxidants could be one mediator of trade-offs between phases. We performed a controlled experiment with zebra finches to examine how songbirds use nutrition to manage trade-offs in antioxidant allocation between endurance flight and subsequent reproduction. Our treatment groups included (1) a non-supplemented, non-exercised group (control group) fed a standard diet with no exercise beyond that experienced during normal activity in an aviary; (2) a supplemented non-exercised group fed a water- and lipid-soluble antioxidant-supplemented diet with no exercise; (3) a non-supplemented exercised group fed a standard diet and trained to perform daily endurance flight for 6 weeks; and (4) a supplemented exercised group fed an antioxidant-supplemented diet and trained to perform daily flight for 6 weeks. After flight training, birds were paired within treatment groups for breeding. We analyzed eggs for lutein and vitamin E concentrations and the plasma of parents throughout the experiment for non-enzymatic antioxidant capacity and oxidative damage. Exercised birds had higher oxidative damage levels than non-exercised birds after flight training, despite supplementation with dietary antioxidants. Supplementation with water-soluble antioxidants decreased the deposition of lipid-soluble antioxidants into eggs and decreased yolk size. Flight exercise also lowered deposition of lutein, but not vitamin E, to eggs. These findings have important implications for future studies of wild birds during migration and other oxidative challenges.
Exploration into a New Dicarboxylic Acid Derived from Ricinoleic Acid for High-Performance Aluminum Electrolytic Capacitors
Authors: Mizota Isao , Umeshima Satoshi , Matsunaga Sei , Isomura Rinpei , Nakahama Kenta , Shimizu Makoto , Yokomori Yorozu , Umemura Tokihiro , Kuroki Noburo , Kiyosawa Junich , Tanaka Hiroyuki 
Published: August 2016

Abstract
New dicarboxylic acids were synthesized from ricinoleic acid in 3–8 steps in good overall yields, and they were found to be effective as an electrolyte in aluminum electrolytic capacitors. These types of dicarboxylic acids show good heat-resistance and higher withstand voltage than conventional electrolytes.
Supporting patients living with and beyond cancer in primary care
Authors: Harker Nicola 
Published: August 2016

By improving their awareness of cancer-related patient concerns, practice nurses could contribute more to the overall management of cancer patients. Dr Nicola Harker highlights opportunities for nurses to address unmet needs, providing proactive, holistic care. The needs of cancer patients in the UK are changing with many more people surviving cancer. This article highlights how practice nurses are ideally placed to address some of the unmet needs of people living with and beyond cancer, and considers how to recognise and help manage potential long-term conditions.
Rapid Screening of Sulfuryl Fluoride as a Potential Phytosanitary Treatment for a Broad Selection of Fungi Relevant to Forestry
Authors: Uzunovic Adnan , Mukherjee Ananya , Elder Peggy , Myers Scott W. 
Published: August 2016

Abstract
Increasing restrictions on the use of methyl bromide have created an urgent need to find suitable replacements that are effective in eliminating exotic pest establishments via trade in wood products. Efficacy data for established phytosanitary fumigants have primarily focused on arthropods and nematodes, whereas limited information exists for plant pathogens and fungi relevant to forestry. A rapid screening process was developed to evaluate efficacy and compare relative tolerance to fumigation treatments for a broad selection of relevant fungi under laboratory conditions. Sulfuryl fluoride (SF) fumigations were conducted in 10-liter glass chambers at six target concentrations (40 to 240 mg liter−1) at 15°C and 20°C for 24-, 48-, and 72-hour exposure times against 23 fungal species represented with 35 isolates. Fungi were grown on sterilized barley grain and then distributed in felt-covered borosilicate glass tubes to allow uninhibited gas penetration during fumigation while minimizing the risk of fungal contamination. This allowed simultaneous testing of numerous species and isolates, followed by 100 percent recovery of controls without contamination. Results demonstrate that SF is an effective fumigant for a broad range of fungi. Several fungi and isolates were found to consistently be among the most tolerant to the fumigant treatment. These species may serve as a benchmark for screening SF in fumigations of logs and other wood products. Methods developed here will be useful in efficacy screening of other methyl bromide fumigant alternatives.
Efficacy and safety of rivaroxaban thromboprophylaxis after arthroplasty of the hip or knee: retrospective cohort study
Authors: Loganathan V , Hua A , Patel S , Gibbons C , Vizcaychipi MP 
Published: August 2016

Introduction Venous thromboembolism (VTE) is a potentially fatal complication of hip arthroplasty and knee arthroplasty. The National Institute for Health and Care Excellence recommend rivaroxaban for VTE prevention. Amid concerns over bleeding complications, the modified thromboprophylaxis policy of Chelsea and Westminster Hospital (CWH; London, UK) advises enoxaparin given after surgery in the inpatient setting followed by rivaroxaban upon hospital discharge. This retrospective study investigated the efficacy and safety of rivaroxaban in this novel, modified venous-prophylaxis regimen in a surgical orthopaedic cohort at CWH. Methods A total of 479 patients who received modified thromboprophylaxis treatment at CWH after hip arthroplasty or knee arthroplasty between April 2013 and October 2014 formed the study cohort. Seven outcomes based on efficacy and safety while undergoing treatment with rivaroxaban were investigated: symptomatic deep-vein thrombosis (DVT), pulmonary embolism (PE), death, stroke, myocardial infarction (MI), major bleeding episodes (MBEs) and non-major bleeding episodes (NMBEs). Median follow-up was 369 days. Fisher’s exact and Mann–Whitney U-tests were adopted to identify associations with these outcomes. Results Prevalence of symptomatic PE, DVT, death, stroke and MI during treatment was zero. One (0.2%) MBE and nine (1.9%) NMBEs occurred. The MBE (a wound haematoma) required a return to theatre for aspiration. Off-treatment VTEs occurred in four (0.8%) patients after completion of a course of rivaroxaban, and were associated with known risk factors. Conclusions Rivaroxaban is an effective and safe anticoagulant for thromboprophylaxis after hip arthroplasty or knee arthroplasty if used in a modified regimen involving enoxaparin administered in the inpatient setting followed by rivaroxaban upon hospital discharge.
Construction of the female global top manager in The Economist
Authors: Poutanen Seppo , Kovalainen Anne , Jännäri Jatta 
Published: August 2016

Abstract
This article analyses the portrayal of the female corporate manager in the economic media. More specifically the article examines the ways in which femininity and gendered power become enacted in feature articles about high level corporate leaders and managers in the global economic newspaper, The Economist, and through that enacted as part of the wider gender asymmetry in the economy. The media has a crucial role in constructing, changing and stabilizing representations, stereotypes and images. The article identifies, categorizes and presents managers as genderspecific social actors and members of elite business groups. Feature articles in The Economist about top managers were analysed over the period 2006–2013 with the help of thematic classifications influenced by critical discourse analysis. The analysis demonstrates that the global economy-focused print media has contributed to fending off and defining a ‘suitable managerial femininity’ for female managers that is aligned with the ideology of the third spirit of capitalism, but does not threaten the reigning masculinity of corporate management elite.
East to East: Cultural politics and fandom of Korean popular culture in Eastern Europe
Authors: Yoon Sunny 
Published: August 2016

Abstract
This study examines the popularity of South Korean media in Eastern Europe as a case of cultural politics. Strong fandom and subcultural activities related to Korean media in this region show not only temporary cultural trends but also social changes and public aspirations in these countries. Media audiences use Korean popular culture as a way of expressing their visions of social and cultural construction different from western systems. Currently facing new crises and despair after transitioning from the breakdown of socialism, people in these countries actively seek alternatives to both Eastern European communist and capitalist western development. This politically motivated cultural practice of media use demonstrates a case of soft power that phases the cultural dimension of politics motivated by the people. As an empirical endeavour of conceptual framework of cultural politics, an ethnographic research, including field studies with in-depth interviews and the participatory observation of social media, was conducted in Romania and Hungary. This research finds that criticism of national politics and the hasty adoption of the western system are the starting points for fan groups that indulge in Korean media, which simultaneously depict traditional values and rapid development towards modernity. Fans of Korean media in this region show nostalgia and Korean dreams that disclose the collective desires and social consciousness of the people at present. This study identifies cultural politics as an exercise of soft power and driving forces for the popularity of Korean media in post-socialist Europe.
International careers and cross-border cultural exchanges: Transition or continuity in the Baltic art worlds from 1960 until present?
Authors: Duester Emma 
Published: August 2016

Abstract
During the Cold War, there were many cross-border cultural exchanges between the western and eastern blocs. Soviet citizens were travelling out of the Soviet Union on group tourism tips and European citizens were travelling into the Soviet Union to source out artistic talent for exhibitions in Western Europe. Due to their histories, the Baltic art worlds are today heavily government funded and are only beginning to develop commercially. However, arts professionals are trying to change this – as after having worked or studied abroad they are returning with expertise and international contacts. These returnees are also, subsequently, more mobile and connected across the European Union. The Baltic States’ histories have had an impact on how current structures operate. This is why it is important to ask whether there has been transition or continuity in the Baltic art worlds since 1960. It is important to look at the development of these art worlds alongside cultural, political and economic changes happening in this region (and across the European Union) in order to see how and why they have changed (or not). Furthermore, an understanding of how Tallinn, Riga and Vilnius art scenes are in transition today cannot be understood fully without situating it within an historical context. More broadly, this article will shed light on the changes (and some similarities) in movements and communications across Europe – throughout history and today.
ANALISIS PERKEMBANGAN INDUSTRI KECIL DAN RUMAH TANGGA DENGAN PENDEKATAN DPSIR: STUDI KASUS DI KECAMATAN CIPARAY, KABUPATEN BANDUNG
Authors: Wijaya Nurrohman , Mutia Muhammad Aziz Ali 
Published: August 2016

<p class="TitleEnglish">Micro, Small, and Medium-Sized Enteprises (UMKM) have a significant potential in contribution to local economic development in Indonesia. Within the development of economic sector and a dynamic population in Kecamatan Ciparay, UMKM of manufacturing industry is increasing as well, especially the small and home industries. Nevertheless, the industries still not put into practice optimally yet and give less contribution to the local economy. This article aims to analyze the development of the small and home industries in Kecamatan Ciparay with an analysis approach of DPSIR (Driver, Pressure, State, Impact and Response). The study applied descriptive research method. Questionnaire, interview and field observation were conducted in the study area. The results found that the development of the small and home industries is driven by some driver factors such as industrialization, socio-economic dynamic as well as local policy and strategy aspects. DPSIR model approach has identified some driver factors and the impacts of the small and home industries in a comprehensive system. A considerable attention of local government and decision makers becomes crutial focal point in order to support the UMKM in Kecamatan Ciparay. </p>
Contribution of intertwined loop to membrane association revealed by Zika virus full‐length NS1 structure
Authors: Xu Xiaoying , Song Hao , Qi Jianxun , Liu Yuqian , Wang Haiyuan , Su Chao , Shi Yi , Gao George F 
Published: August 2016

AbstractThe association of Zika virus (ZIKV) infections with microcephaly and neurological diseases has highlighted an emerging public health concern. Here, we report the crystal structure of the full‐length ZIKV nonstructural protein 1 (NS1), a major host‐interaction molecule that functions in flaviviral replication, pathogenesis, and immune evasion. Of note, a long intertwined loop is observed in the wing domain of ZIKV NS1, and forms a hydrophobic “spike”, which can contribute to cellular membrane association. For different flaviviruses, the amino acid sequences of the “spike” are variable but their common characteristic is either hydrophobic or positively charged, which is a beneficial feature for membrane binding. Comparative studies with West Nile and Dengue virus NS1 structures reveal conserved features, but diversified electrostatic characteristics on both inner and outer faces. Our results suggest different mechanisms of flavivirus pathogenesis and should be considered during the development of diagnostic tools.
Magnetresonanztomographische und klinische Befunde von drei Hunden nach Kohlenmonoxidvergiftung
Authors: von Pückler Kerstin , De Decker Steven , Cortellini Stefano , Wurtinger Gabriel , Schmidt Martin , Kolecka Malgorzata 
Published: August 2016

ZusammenfassungPräsentiert werden magnetresonanztomographische Befunde von drei Hunden nach Kohlenmonoxidvergiftung. Im ersten und zweiten Fall umfassten die Befunde Veränderungen im Nucleus caudatus auf beiden Seiten und im ersten Fall auch im Putamen als bilateral symmetrische, diffuse, homogene, in T2 und FLAIR hyperintense, in T1 hypointense Läsionen. Eine Kontrastmittelaufnahme zeigte sich nicht. Beim dritten Hund fanden sich sowohl multiple bilateral symmetrische in T2 und FLAIR hyperintense Läsionen als auch schlecht abgrenzbare Areale in der grauen Substanz im Frontal-, Parietal- und Okzipitallappen. Beide Colliculi caudales, Globus pallidus, Substantia nigra und der mittlere Thalamus stellten sich bilateral symmetrisch hyperintens in T2 und FLAIR dar und nach intravenöser Kontrastmittelapplikation kam es zu einer mittelgradigen Anreicherung.
Subjective well-being in directives of the Oriente´s Transport Company/Bienestar subjetivo en directivos de la Empresa de Transporte de Oriente
Authors: Reyes Pérez Liudmila , López Mustelier Rosendo , Reyes Saborit Aymara 
Published: August 2016

La investigación tiene el objetivo de identificar indicadores para el análisis del Bienestar Subjetivo (BS) en directivos de una Empresa de la Transporte de Oriente. Se basa en la metodología cualitativa empleando técnicas de entrevista en profundidad, observación participante, escala de Bienestar Psicológico y el análisis de contenido. Los resultados permitieron definir como indicadores: el desempeño efectivo del rol directivo en la organización; el efecto de la actividad directiva en otras esferas de la vida; la integración armónica de los valores; la configuración subjetiva de la actividad directiva y el bienestar psicológico, los cuales permitieron proponer una estrategia de intervención psicológica basada enla Indagación Apreciativa para potenciar BS en los directivos de dicha empresa que actualmente está en proceso de aplicación.
A História da Ciência Mediante Análise Fílmica
Authors: De Sena Juliana Yporti , Ferreira Mário Cézar Alves , Rocha Zenaide De Fátima Dante Correia 
Published: August 2016

<p>A atividade como cinema em sala de aula exige do professor uma série de procedimentos pedagógicos, aos quais deve o professor estar sempre atento, pois são fundamentais para o sucesso da aula. Sabendo dessa importância, este trabalho apresenta uma reflexão sobre um procedimento metodológico pautado na pedagogia histórico-crítica, utilizado por um professor de Ciências e um professor de História, aplicado a uma turma de quatro alunos do Ensino Fundamental II de uma escola particular de Londrina, no ano de 2014. De natureza qualitativa, o trabalho foi embasado nos pressupostos teóricos da pedagogia Histórico-Crítica, do Professor Gasparin e teve como substrato os conteúdos Radiação e a Construção do Conhecimento Científico, apresentados por meio do filme “Madame Curie”, baseado na biografia da famosa cientista, escrita por sua filha, Eve Curie. Ao utilizarem o filme, veiculando conteúdos de química e de história da ciência, professores e estudantes puderam discutir e analisar, de forma mais crítica e interativa, o modo como se dá a construção do conhecimento científico. Outra contribuição desta abordagem metodológica é o aspecto lúdico, crítico e reflexivo, contrapondo-se à abordagem tradicional. Dentre os resultados promissores da experiência<br />didática destaca-se a mobilização de um espaço para formação cidadã, no qual os educandos tiveram a oportunidade de desmitificar visões estereotipadas sobre os conteúdos trabalhados.</p>
Cinema e Literatura: do Clássico ao Moderno
Authors: Evangelista Josiane Luzia , Calzavara Rosemari Bendlin 
Published: August 2016

<p>O cinema e a literatura mantêm uma relação quase tão antiga quanto o próprio surgimento do cinema. A sétima arte, corroborando o seu potencial narrativo, aliou-se a um modo já consagrado de contar histórias, a literatura. O presente trabalho traz reflexões sobre a aplicação de sequências didáticas utilizando como ferramenta tecnológica a mídia cinema para os conteúdos de literatura, na disciplina de Língua Portuguesa. A proposta de trabalho em sala de aula foi desenvolvida em duas turmas do primeiro ano do ensino médio, em um colégio estadual no município de Ibiporã, Paraná e seguiu, de acordo com Antoni Zabala (1998), uma sequência didática. Foram desenvolvidas atividades baseadas no conto clássico da literatura infantil A Bela Adormecida, recentemente transposto para o cinema com nova releitura intitulada Malévola, adaptação que tem como público alvo adolescentes, jovens e adultos, transportando a literatura infantil para a literatura infantojuvenil por meio da arte cinematográfica.</p>