bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Reductive Hydrazination with Trichlorosilane: A Method for the Preparation of 1,1‐Disubstituted Hydrazines.
Authors: Wang Tao , Di Xiao , Wang Chao , Zhou Li , Sun Jian 
Published: July 2016

AbstractTrichlorosilane is shown to be a powerful reducing agent allowing for direct reductive hydrazination of various aldehydes and ketones with phenylhydrazines in the presence of Lewis bases.
ChemInform Abstract: Exploiting Aryl Mesylates and Tosylates in Catalytic Mono‐α‐arylation of Aryl‐ and Heteroarylketones.
Authors: Fu Wai Chung , So Chau Ming , Yuen On Ying , Lee Irene Toi Chuk , Kwong Fuk Yee 
Published: July 2016

AbstractKey to this general protocol for mono‐α‐arylation is the indolyl‐derived phosphine ligand which enhances the steric congestion of the catalyst.
ChemInform Abstract: BF3·OEt2‐AgSCF3 Mediated Trifluoromethylthiolation/Cascade Cyclization of Propynols: Synthesis of 4‐((Trifluoromethyl)thio)‐2H‐chromene and 4‐((Trifluoromethyl)thio)‐1,2‐dihydroquinoline Derivatives.
Authors: Liang Yong‐Min , et al.  
Published: July 2016

AbstractThe reaction can be scaled up.
ChemInform Abstract: Organocatalytic Kinetic Resolution of Sulfoximines.
Authors: Dong Shunxi , Frings Marcus , Cheng Hanchao , Wen Jian , Zhang Duo , Raabe Gerhard , Bolm Carsten 
Published: July 2016

AbstractAn efficient kinetic resolution of sulfoximines with enals using chiral N‐heterocyclic carbene catalysts is investigated.
ChemInform Abstract: Three‐ and Four‐Component Syntheses of 3‐Arylmethylindoles by Microwave‐Assisted One‐Pot Heck Isomerization—Fischer Indolization (Alkylation) (HIFI and HIFIA) Sequences
Authors: Panther Jesco , Mueller Thomas J. J. 
Published: July 2016

Abstractstarting from simple materials such as (hetero)aryl bromides, allyl alcohols, hydrazines, and alkyl bromides
ChemInform Abstract: Z‐Shaped Pyrrolo[3,2‐b]pyrroles and Their Transformation into π‐Expanded Indolo[3,2‐b]indoles.
Authors: Stezycki Rafal , Grzybowski Marek , Clermont Guillaume , Blanchard‐Desce Mireille , Gryko Daniel T. 
Published: July 2016

AbstractThe unique Z‐shaped pyrrolopyrrole dyes show relatively strong fluorescence in solution.
ChemInform Abstract: Organocatalytic Asymmetric Conjugate Addition of Diaryloxazolidin‐2,4‐diones to Nitroolefins: An Efficient Approach to Chiral α‐Aryl‐α‐hydroxy Carboxylic Acids.
Authors: Jiao Lihui , Zhao Xiaowei , Liu Huixin , Ye Xinyi , Li Yun , Jiang Zhiyong 
Published: July 2016

AbstractA series of chiral oxazolidin‐2,4‐diones is prepared by an asymmetric conjugate addition of diones (I) to nitroalkenes (II) in the presence of the urea catalyst PUFP.
ChemInform Abstract: 1,3‐Dipolar Cycloaddition of Azinium Ylides to Alkynyl Hetarenes: A Synthetic Route to Indolizine and Pyrrolo[2,1‐a]isoquinoline Based Heterobiaryls.
Authors: Nelina‐Nemtseva Julia I. , Gulevskaya Anna V. , Pozharskii Alexander F. , Nguyen Huong T. L. , Filatova Ekaterina A. 
Published: July 2016

AbstractFor the first time, π‐deficient alkynyl hetarenes are used as dipolarophiles in a 1,3‐dipolar cycloaddition with in situ generated azinium ylides.
ChemInform Abstract: Synthesis of 1,8‐Naphthyridines from 2‐Aminonicotinaldehydes and Terminal Alkynes.
Authors: Li Binbin , Nguyen Steven , Huang Jianjun , Wang Gaigai , Wei Huiping , Pereshivko Olga P. , Peshkov Vsevolod A. 
Published: July 2016

AbstractA novel copper(II) triflate‐catalyzed reaction of 2‐aminonicotinaldehydes with terminal alkynes providing access to 1,8‐naphthyridine core is described.
ChemInform Abstract: Synthesis of 1,1‐Diboronate Esters by Cobalt‐Catalyzed Sequential Hydroboration of Terminal Alkynes.
Authors: Zuo Ziqing , Huang Zheng 
Published: July 2016

AbstractAn efficient procedure for the Co‐catalyzed conversion of terminal alkyl and aryl alkynes with pinacolborane affording 1,1‐diboronate esters is developed.
ChemInform Abstract: Approach to Merosesquiterpenes via Lewis Acid Catalyzed Nazarov‐Type Cyclization: Total Synthesis of Akaol A.
Authors: Kakde Badrinath N. , Kumar Nivesh , Mondal Pradip Kumar , Bisai Alakesh 
Published: July 2016

AbstractThe new and efficient Lewis acid catalyzed Nazarov‐type cyclization employs only 2 mol% of Sn(OTf)2 and Bi(OTf)3 under mild conditions whereby, with Sn(OTf)2 products are obtained in somewhat lower yields.
ChemInform Abstract: Hyperjapones A—E, Terpenoid Polymethylated Acylphloroglucinols from Hypericum japonicum.
Authors: Yang Xing‐Wei , Li Yan‐Ping , Su Jia , Ma Wei‐Guang , Xu Gang 
Published: July 2016

AbstractNovel terpenoid polymethylated acylphloroglucinols hyperjapone A (I), hyperjapone B (II), and hyperjapones C—E are isolated from Hypericum japonicum.
ChemInform Abstract: Seven New Acyl Glycosides from Erycibe obtusifolia.
Authors: Feng Zi‐Ming , Liu Zhao‐Zhen , Xu Kuo , Yang Ya‐Nan , Jiang Jian‐Shuang , Zhang Pei‐Cheng 
Published: July 2016

AbstractSeven new acyl glycosides (Ia—c), (II), (III), (IV), and (V) are isolated from the dried stems of the Chinese folk herb Erycibe obtusifolia.
ChemInform Abstract: Myrothecoside, a Novel Glycosylated Polyketide from the Terrestrial Fungus Myrothecium sp. GS‐17.
Authors: Zhang Songya , Zhu Jing , Liu Tao , Samra Suzan , Pan Huaqi , Bai Jiao , Hua Huiming , Bechthold Andreas 
Published: July 2016

AbstractMyrothecoside (I), a novel glycosylated polyketide, is isolated from the terrestrial halotolerant fungus Myrothecium sp.
ChemInform Abstract: Ligand‐Controlled Monoselective C‐Aryl Glycoside Synthesis via Palladium‐Catalyzed C—H Functionalization of N‐Quinolyl Benzamides with 1‐Iodoglycals.
Authors: Liu Minglong , Niu Youhong , Wu Yan‐Fen , Ye Xin‐Shan 
Published: July 2016

AbstractAn atom economic and environmentally friendly protocol for C‐glycosylation of iodoglycals is presented.
ChemInform Abstract: Synthesis and Absolute Configuration of Formosusin A, a Specific Inhibitor of Mammalian DNA Polymerase β.
Authors: Yajima Arata , Iizuka Yuu , Katsuta Ryo , Nukada Tomoo 
Published: July 2016

AbstractThe first synthesis of formosusin A (I), with Sharpless asymmetric dihydroxylation of a vinyliodide being the key step, is described.
ChemInform Abstract: Flexible, High Temperature, Planar Lighting with Large Scale Printable Nanocarbon Paper.
Authors: Dames Chris , et al.  
Published: July 2016

AbstractAn ultrapure, highly conductive nanocarbon paper composed of monolayer graphene oxide nanosheets interpenetrated with 10 wt.% single walled carbon nanotubes is fabricated by solution‐printing followed by a self‐stabilizing annealing process under an electrical bias, causing reduction of graphene oxide at high temperatures by Joule heating.
ChemInform Abstract: N‐Alkyl‐2‐halo‐ and 2,2‐Dihaloaldimines in the Pudovik Reaction
Authors: Gazizov M. B. , Khairullin R. A. , Perina A. I. , Minnikhanova A. A. , Aksenov N. G. , Gnezdilov O. I. , Il'yasov A. V. , Khayarov Kh. R. 
Published: July 2016

AbstractReview: 35 refs.
ChemInform Abstract: Reactions of C‐Phosphorylated Acetimidates and Acetamidines, Involving the CH‐Acid Methylene Group
Authors: Shishkin V. E. , Mednikov E. V. , Popov Yu. V. , Shevchenko M. A. , Anishchenko O. V. 
Published: July 2016

AbstractReview: 47 refs.
Limits in Proton Nuclear Singlet‐State Lifetimes Measured with para‐Hydrogen‐Induced Polarization
Authors: Zhang Yuning , Duan Xueyou , Soon Pei Che , Sychrovský Vladimír , Canary James W. , Jerschow Alexej 
Published: July 2016

AbstractThe synthesis of a hyperpolarized molecule was developed, where the polarization and the singlet state were preserved over two controlled chemical steps. Nuclear singlet‐state lifetimes close to 6 min for protons are reported in dimethyl fumarate. Owing to the high symmetry (AA′X3X3′ and A2 systems), the singlet‐state readout requires either a chemical desymmetrization or a long and repeated spin lock. Using DFT calculations and relaxation models, we further determine nuclear spin singlet lifetime limiting factors, which include the intramolecular dipolar coupling mechanism (proton–proton and proton–deuterium), the chemical shift anisotropy mechanism (symmetric and antisymmetric), and the intermolecular dipolar coupling mechanism (to oxygen and deuterium). If the limit of paramagnetic relaxation caused by residual oxygen could be lifted, the intramolecular dipolar coupling to deuterium would become the limiting relaxation mechanism and proton lifetimes upwards of 26 min could become available in the molecules considered here (dimethyl maleate and dimethyl fumarate).
Coating Pt–Ni Octahedra with Ultrathin Pt Shells to Enhance the Durability without Compromising the Activity toward Oxygen Reduction
Authors: Park Jinho , Liu Jingyue , Peng Hsin‐Chieh , Figueroa‐Cosme Legna , Miao Shu , Choi Sang‐Il , Bao Shixiong , Yang Xuan , Xia Younan 
Published: July 2016

AbstractWe describe a new strategy to enhance the catalytic durability of Pt–Ni octahedral nanocrystals in the oxygen reduction reaction (ORR) by conformally depositing an ultrathin Pt shell on the surface. The Pt–Ni octahedra were synthesized according to a protocol reported previously and then employed directly as seeds for the conformal deposition of ultrathin Pt shells by introducing a Pt precursor dropwise at 200 °C. The amount of Pt precursor was adjusted relative to the number of Pt–Ni octahedra involved to obtain Pt–Ni@Pt1.5L octahedra of 12 nm in edge length for the systematic evaluation of their chemical stability and catalytic durability compared to Pt–Ni octahedra. Specifically, we compared the elemental compositions of the octahedra before and after treatment with acetic and sulfuric acids. We also examined their electrocatalytic stability toward the ORR through an accelerated durability test by using a rotating disk electrode method. Even after treatment with sulfuric acid for 24 h, the Pt–Ni@Pt1.5L octahedra maintained their original Ni content, whereas 11 % of the Ni was lost from the Pt–Ni octahedra. After 10 000 cycles of ORR, the mass activity of the Pt–Ni octahedra decreased by 75 %, whereas the Pt–Ni@Pt1.5L octahedra only showed a 25 % reduction.
Enrichment of Pyrrolic Nitrogen by Hole Defects in Nitrogen and Sulfur Co‐Doped Graphene Hydrogel for Flexible Supercapacitors
Authors: Tran Ngoc Quang , Kang Bong Kyun , Woo Moo Hyun , Yoon Dae Ho 
Published: July 2016

AbstractThe effect of the doping configuration and concentration of nitrogen (N) and sulfur (S) on the electrochemical performance of 3 D N and S co‐doped hole defect graphene hydrogel (NS‐HGH) electrodes is investigated. Surprisingly, by introducing a hole defect on the graphene surface, the difference in the doping concentrations of N and S can be used to effectively modulate the electrochemical behavior of the NS‐HGH. The hole defects provide a rapid ion diffusion path. Finally, we showed that the intriguing specific capacitance (536 F g−1) of the NS‐HGH could enhance the overall performance of the pseudocapacitance and electric double layer capacitance. The rational design of the NS‐HGH‐based flexible solid state supercapacitor results in not only outstanding electrochemical performance with a maximum energy density of 14.8 Wh kg−1 and power density of 5.2 KW kg−1 but also in extraordinary mechanical flexibility and excellent cycle stability.
Saltmarsh plant responses to eutrophication
Authors: Johnson David Samuel , Warren R. Scott , Deegan Linda A. , Mozdzer Thomas J. 
Published: July 2016

AbstractIn saltmarsh plant communities, bottom‐up pressure from nutrient enrichment is predicted to increase productivity, alter community structure, decrease biodiversity, and alter ecosystem functioning. Previous work supporting these predictions has been based largely on short‐term, plot‐level (e.g., 1–300 m2) studies, which may miss landscape‐level phenomena that drive ecosystem‐level responses. We implemented an ecosystem‐scale, nine‐year nutrient experiment to examine how saltmarsh plants respond to simulated conditions of coastal eutrophication. Our study differed from previous saltmarsh enrichment studies in that we applied realistic concentrations of nitrate (70–100 μM NO3−), the most common form of coastal nutrient enrichment, via tidal water at the ecosystem scale (~60,000 m2 creeksheds). Our enrichments added a total of 1,700 kg N·creek−1·yr−1, which increased N loading 10‐fold vs. reference creeks (low‐marsh, 171 g N·m−2·yr−1; high‐marsh, 19 g N·m−2·yr−1). Nutrients increased the shoot mass and height of low marsh, tall Spartina alterniflora; however, declines in stem density resulted in no consistent increase in aboveground biomass. High‐marsh plants S. patens and stunted S. alterniflora did not respond consistently to enrichment. Nutrient enrichment did not shift community structure, contrary to the prediction of nutrient‐driven dominance of S. alterniflora and Distichlis spicata over S. patens. Our mild responses may differ from the results of previous studies for a number of reasons. First, the limited response of the high marsh may be explained by loading rates orders of magnitude lower than previous work. Low loading rates in the high marsh reflect infrequent inundation, arguing that inundation patterns must be considered when predicting responses to estuarine eutrophication. Additionally, we applied nitrate instead of the typically used ammonium, which is energetically favored over nitrate for plant uptake. Thus, the form of nitrogen enrichment used, not just N‐load, may be important in predicting plant responses. Overall, our results suggest that when coastal eutrophication is dominated by nitrate and delivered via flooding tidal water, aboveground saltmarsh plant responses may be limited despite moderate‐to‐high water‐column N concentrations. Furthermore, we argue that the methodological limitations of nutrient studies must be considered when using results to inform management decisions about wetlands.
The predictability of mosquito abundance from daily to monthly timescales
Authors: Jian Yun , Silvestri Sonia , Brown Jeff , Hickman Rick , Marani Marco 
Published: July 2016

AbstractThe prediction of mosquito abundance is of central interest in addressing mosquito population dynamics and in forecasting the associated emerging and re‐emerging diseases. However, little work has focused on the systematic evaluation of how well adult mosquito abundance can be predicted as a function of observational resolutions, aggregation scales, and prediction lead time. We use a state space reconstruction (SSR) approach to compare the predictability of mosquito population dynamics at weekly, biweekly, and monthly scales. We focus on the analysis of Aedes vexans and Culiseta melanura populations monitored in Brunswick County (North Carolina, USA) and find that prediction over a 7‐d lead time is improved when daily observations are used, compared to the commonly used once‐per‐week sample. Our results demonstrate that daily observations of mosquito abundance contribute to improving mosquito predictability in two ways: (1) daily observations better capture fluctuations over short timescales, which are missed when sampling at coarser resolutions, and (2) the aggregation of daily abundance observations reduces the impact of noise, thereby increasing the predictability of mosquito population dynamics as the aggregation scale is increased. We show that the evaluation of population dynamical models based on observed and predicted abundance can lead to a spuriously high apparent performance, due to the high autocorrelation in the observations used to update the model state at each successive time step. We show that the comparison of predicted and observed population change, expressed through per capita growth rates, leads to a more informative performance measure.
Predictors for future clinically significant pain in patients with temporomandibular disorder: A prospective cohort study
Authors: Forssell H. , Kauko T. , Kotiranta U. , Suvinen T. 
Published: July 2016

AbstractBackgroundUp to 30% of patients with temporomandibular disorder (TMD) run the risk of progressing to chronic pain with significant disability. This prospective cohort study assessed the effects of baseline pain and general health and psychosocial factors on the presence of clinically significant pain in patients with TMD pain at 1 year after initial consultation.Methods263 primary care patients with TMD pain were included. At the baseline, patients completed a pain questionnaire including a wide range of putative prognostic factors, which were assessed using validated self‐report scales. The outcome, clinically significant pain at 1 year was defined as grades IV and III and grades II and I with any disability points on the Graded Chronic Pain Scale (GCPS). Multivariable logistic regression was used to study the association between the outcome and each predictor variable.ResultsAt 1 year, 26.9% of the patients reported clinically significant pain. The number of previous healthcare visits (OR 1.19, 95% CI 1.02–1.39), pain intensity/dysfunction of other pain conditions (OR 1.35, 95% CI 1.07–1.69), the number of other pain conditions (OR 1.31, 95% CI 0.98–1.74), the number of disability days (OR 1.05, 95% CI 1.00–1.12), and perceived ability to control pain (OR 0.79, 95% CI 0.61–1.01) were associated with the outcome. The area under the curve (AUC) for the whole model indicated acceptable discriminative ability (0.74, 95% CI 0.66–0.82).ConclusionsReporting several previous healthcare visits and comorbid pains with high pain intensity and disability signal increased risk for poor prognosis of TMD pain.SignificanceAbout 27% of primary care TMD pain patients reported clinically significant pain at 1 year after initial consultation. Reporting several previous healthcare visits and comorbid pains with high pain intensity and disability were associated with poor prognosis of TMD pain.
Not all that glitters is gold: A guide to surgical trials in epilepsy
Authors: Jehi Lara , Jetté Nathalie 
Published: July 2016

SummaryEpilepsy surgery is often the only effective treatment in appropriately selected patients with drug‐resistant epilepsy, a disease affecting about 30% of those with epilepsy. We review the evidence supporting the use of epilepsy surgery, with a focus on randomized controlled trials (RCTs). Second, we identify gaps in knowledge about the benefits of epilepsy surgery for certain populations, the challenges of individualizing the choice of surgery, and our lack of understanding of the mechanisms of surgical outcomes. We conducted a search (MEDLINE, Embase, Cochrane, Clinicaltrials.gov) on March 2, 2016, to identify epilepsy surgery RCTs, systematic reviews, or health technology assessments (HTAs). Abstracts were screened to identify resective, palliative (e.g., corpus callosotomy, multiple subpial transection [MST]), ablative (e.g., Laser interstitial thermal therapy [LITT], gamma knife radiosurgery [RS]), and neuromodulation (e.g., cerebellar stimulation [CS], hippocampal stimulation [HS], repetitive transcranial magnetic stimulation [rTMS], responsive neurostimulation [RNS], thalamic stimulation [TS], trigeminal nerve stimulation [TNS], and vagal nerve stimulation [VNS]) RCTs. Study characteristics and outcomes were extracted. Knowledge gaps were identified. Of 1,205 abstracts, 20 RCTs were identified (resective surgery including corpus callosotomy [n = 7], MST [n = 0], RS [n = 1, 3 papers], LITT [n = 0], CS [n = 1], HS [n = 2], RNS [n = 1], rTMS [n = 1], TNS [n = 1], TS [n = 1], and VNS [n = 5]). Most studies targeted patients with temporal lobe epilepsy (TLE) and none examined the effectiveness of resective surgical therapies in patients with extra‐TLE (ETLE) or with specific lesions aside from mesial temporal lobe sclerosis. No pediatric surgical RCTs were identified except for VNS. Few RCTs address the effectiveness of surgery in epilepsy and most are of limited generalizability. Future studies are needed to compare the effectiveness of different surgical strategies, better understand the mechanisms of surgical outcomes, and define the ideal surgical approaches, particularly for patients with high or very low cognitive function, normal imaging, or ETLE.
Correlation and Lead–Lag Relationships in a Hawkes Microstructure Model
Authors: Da Fonseca José , Zaatour Riadh 
Published: July 2016

AbstractThe aim of this paper is to develop a multi‐asset model based on the Hawkes process describing the evolution of assets at high frequency and to study the lead–lag relationship as well as the correlation between the assets within this framework. We compute several statistical quantities and the covariance matrix associated with the diffusive limit of the model so that the relation between the parameters driving the assets at high and low frequencies is explicit. We illustrate the results using several financial assets quoted in the Eurex market and show how the model captures the lead–lag relationship between them. © 2016 Wiley Periodicals, Inc. Jrl Fut Mark 37:260–285, 2017
Flexing the PECs: Predicting environmental concentrations of veterinary drugs in Canadian agricultural soils
Authors: Kullik Sigrun A , Belknap Andrew M 
Published: July 2016

Abstract

Veterinary drugs administered to food animals primarily enter ecosystems through the application of livestock waste to agricultural land. Although veterinary drugs are essential for protecting animal health, their entry into the environment may pose a risk for nontarget organisms. A means to predict environmental concentrations of new veterinary drug ingredients in soil is required to assess their environmental fate, distribution, and potential effects. The Canadian predicted environmental concentrations in soil (PECsoil) for new veterinary drug ingredients for use in intensively reared animals is based on the approach currently used by the European Medicines Agency for VICH Phase I environmental assessments. The calculation for the European Medicines Agency PECsoil can be adapted to account for regional animal husbandry and land use practices. Canadian agricultural practices for intensively reared cattle, pigs, and poultry differ substantially from those in the European Union. The development of PECsoil default values and livestock categories representative of typical Canadian animal production methods and nutrient management practices culminates several years of research and an extensive survey and analysis of the scientific literature, Canadian agricultural statistics, national and provincial management recommendations, veterinary product databases, and producers. A PECsoil can be used to rapidly identify new veterinary drugs intended for intensive livestock production that should undergo targeted ecotoxicity and fate testing. The Canadian PECsoil model is readily available, transparent, and requires minimal inputs to generate a screening level environmental assessment for veterinary drugs that can be refined if additional data are available. PECsoil values for a hypothetical veterinary drug dosage regimen are presented and discussed in an international context. Integr Environ Assess Manag 2017;13:331–341. © 2016 Her Majesty the Queen in Right of Canada. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of SETAC. Reproduced with the permission of the Minister of Health.

Key Points
Defaults and production classes that correspond to predominant Canadian agricultural practices have been developed for the PECsoil calculation for intensively reared livestock used in the European Union during VICH Phase I. The Canadian PECsoil model is readily available, transparent, and requires minimal inputs to generate a screening level environmental assessment for veterinary drugs that can be refined if additional data are available. PECsoil values for a hypothetical veterinary drug dosage regimen for cattle, pork, and poultry are presented and discussed in an international context. The Canadian PECsoil can serve as a template for adaptation of the EMA PECsoil model for VICH Phase I environmental assessment of new veterinary drugs in other regions.