bluuebunny/crossref_metadata_2025_split huggingface dataset:
Appropriateness of Surgical Antibiotic Prophylaxis in Pediatric Patients in Italy
Authors: Giordano Mariavalentina , Squillace Lorena , Pavia Maria 
Published: June 2017

OBJECTIVESAppropriate use of surgical antibiotic prophylaxis (SAP) reduces intraoperative wound contamination in pediatric surgery, thus minimizing the risk of surgical site infection (SSIs). Conversely, inappropriate use of SAP exposes patients to the risk of antibiotic side effects and contributes to the emergence of antimicrobial resistance. Our aims were to describe SAP administration and to analyze factors associated with nonadherence in pediatric patients.DESIGNDescriptive study.SETTINGOverall, 955 pediatric patients underwent 1,038 surgical procedures.METHODSWe assessed adherence to SAP international guidelines for surgical procedures performed on children aged <18 years in 2015 in 4 randomly selected hospitals in Calabria (Italy). The clinical records of these patients were retrospectively reviewed.RESULTSAppropriate SAP administration or nonadministration pertained to 754 surgical procedures (72.6%). Surgical antibiotic prophylaxis was administered in 88.5% of 358 procedures with an SAP indication. Adherence to guidelines for appropriate drug choice were followed in 5.7% of cases, for route of administration in 76.7% of cases, for timing in 48.6% of cases, for duration in 14.5% of cases, and for dose in 91.5% of cases, and for all components in only 5 cases (1.6%). Among 680 procedures without SAP indication, 35.7% case patients received antibiotics. Inappropriate administration of antibiotics in procedures without SAP indication was associated with surgical specialty wards (P=.008), ordinary admission (P<.001), head and neck surgical procedures (P=.020), clean surgery (P=.017), and surgical duration (P=.010).CONCLUSIONSDiscrepancies between SAP guidelines and actual practice behavior more frequently indicate excessive use of antibiotics than underuse. Increased awareness of SAP guidelines is required.Infect Control Hosp Epidemiol 2017;38:823–831
Prokaryotic functional expression and activity comparison of three CYP9A genes from the polyphagous pestHelicoverpa armigera
Authors: Liu D. , Tian K. , Yuan Y. , Li M. , Zheng M. , Qiu X. 
Published: June 2017

AbstractCytochrome P450s (CYPs or P450s) have been long recognized as very important enzymes in the metabolism of xenobiotic and endogenous compounds, but only a few CYPs have been functionally characterized in insects. The effort in functional characterization of insect P450s is heavily hindered by technical difficulties in preparing active, individual P450 enzymes directly from the target insect. In this paper, we describe the functional expression of two additional pyrethroid resistance-associated CYP9A genes (CYP9A12andCYP9A17) from the polyphagous pestHelicoverpa armigerain the facileEscherichia coli. The functionality ofE. coliproduced CYP9A12, CYP9A14, and CYP9A17 was investigated and activities of these CYP9As were compared against three probe substrates after reconstitution with NADPH-dependent cytochrome P450 reductase. The results showed that active forms of CYP9A12 and CYP9A17 were expressed inE. coliwith a content of about 1.0–1.5 nmol mg−1protein in membrane preparations.In vitroassays showed that CYP9A14 was capable of catalyzing O-dealkylation of methoxyresorufin (MROD), ethoxyresorufin (EROD), and benzyloxyresorufin (BROD), while CYP9A12 and CYP9A17 exhibited only MROD and EROD activities. Kinetic studies demonstrated that CYP9A14 had the greatestkcat/Kmvalue for MROD, and CYP9A17 for EROD, while the lowestkcat/Kmvalues for both MROD and EROD were observed for CYP9A12. The distinct biochemical traits suggest that the three paralogous CYP9As may play different roles in xenobiotic metabolism in this important pest.
Seed treatments with thiamine reduce the performance of generalist and specialist aphids on crop plants
Authors: Hamada A.M. , Fatehi J. , Jonsson L.M.V. 
Published: June 2017

AbstractThiamine is a vitamin that has been shown to act as a trigger to activate plant defence and reduce pathogen and nematode infection as well as aphid settling and reproduction. We have here investigated whether thiamine treatments of seeds (i.e. seed dressing) would increase plant resistance against aphids and whether this would have different effects on a generalist than on specialist aphids. Seeds of wheat, barley, oat and pea were treated with thiamine alone or in combination with the biocontrol bacteriaPseudomonas chlororaphisMA 342 (MA 342). Plants were grown in climate chambers. The effects of seed treatment on fecundity, host acceptance and life span were studied on specialist aphids bird cherry-oat aphid (Rhopalosiphum padiL.) and pea aphid (Acyrthosiphon pisumHarris) and on the generalist green peach aphid (Myzus persicae, Sulzer). Thiamine seed treatments reduced reproduction and host acceptance of all three aphid species. The number of days to reproduction, the length of the reproductive life, the fecundity and the intrinsic rate of increase were found reduced for bird cherry-oat aphid after thiamine treatment of the cereal seeds. MA 342 did not have any effect in any of the plant-aphid combinations, except a weak decrease of pea aphid reproduction on pea. The results show that there are no differential effects of either thiamine or MA 342 seed treatments on specialist and generalist aphids and suggest that seed treatments with thiamine has a potential in aphid pest management.
Silurian radiolarians from the Sepon Mine, Truong Son Terrane, central Laos and their palaeogeographic and tectonic significance
Authors: THASSANAPAK HATHAITHIP , UDCHACHON MONGKOL , BURRETT CLIVE 
Published: June 2017

AbstractA Silurian radiolarian fauna based on 18 species is described from cherts from three sections in two quarries in the Sepon Mine area, central Laos. Each section contains distinctive assemblages butFutobari morishitai,F. solidus,Zadrappolus yoshikiensisandZ. tenuisare found in all three sections and are characteristic of the Ludlow–PridoliZ. yoshikiensisAssemblage. In addition, the Hoei Yang pit section containsZadrappolus hitoeganensis,Pseudospongoprunum sagittatum,Futobarisp. andSecuicollactasp. Section CQ containsPseudospongoprunum sagittatum,P. tazukawaensis,Praespongocoelia parva,P. sp.,Rotasphaerasp. cf.R. quadrata,Secuicollactasp. cf.cassa. Section QM also containsPseudospongoprunum parvispina,P.sp.,Zadrappolussp. andDevoniglansus(?)seponensisnew species Thassanapak is common. Evidence from Silurian and Devonian strata of the southern Truong Son Terrane indicates deepening towards the southern margin as defined by the Thakhek–Danang Shear Zone and exemplified by deep-marine Ludlow–Pridoli radiolarian cherts in the south, shallowing to fossiliferous, shallow-water sediments to widespread Old Red Sandstone type terrestrial facies 85 km further NE. The radiolarian cherts are in faulted contact with probable Llandovery limestone and Upper Ordovician – Llandovery graptolitic shales. The graptolitic shales are overlain with slight angular unconformity by the submarine fan, volcaniclastic-dominated, Namphuc Formation of Llandovery age. This fan received andesitic materials from the nearby Long Dai Volcanic Arc which extends eastwards to the Tamky Suture in Vietnam. This plutonic–volcanic arc was probably maintained by northwards subduction along the trend of the Permian–Recent Thakhek–Danang Shear Zone.
Geochronology, petrology and geochemistry of the Mesozoic Dashizhuzi granites and lamprophyre dykes in eastern Hebei – western Liaoning: implications for lithospheric evolution beneath the North China Craton
Authors: XIONG LE , WEI JUNHAO , SHI WENJIE , FU LEBING , LI HUAN , ZHOU HONGZHI , CHEN JIAJIE , CHEN MENGTING 
Published: June 2017

AbstractGeochronological, elemental and isotopic data of the Dashizhuzi granites and lamprophyre dykes from the eastern Hebei – western Liaoning on the northern North China Craton (NCC) provide an insight into the nature of their magma sources and subcontinental lithospheric mantle. The Dashizhuzi granites have an emplacement age of 226 Ma. They have enriched lithospheric mantle type 1 (EM1-like) Sr–Nd isotopic compositions, and have distinctive features of high Na2O and Sr and low Y with high Sr/Y and (La/Yb)Nratios. These characteristics show that the Dashizhuzi granites originated directly from melting of mafic lower crust composed of pre-existing ancient crustal and enriched mantle-derived juvenile crustal materials at normal continental crustal depth of 33–40 km. The lamprophyre dykes are dated at 167 Ma, and can be divided into two groups. The Group 1 dykes have variable Sr–Nd isotopic compositions and mid-ocean-ridge basalt (MORB-) like Th/U, Ba/Th and Ce/Pb ratios, whereas the Group 2 dykes have enriched Sr–Nd isotopic compositions and notable high Co, Cr, MgO and low Al2O3characteristics. These distinctive features suggest that the Group 1 dykes were derived from a relatively fertile lithospheric mantle source (garnet-facies amphibole-bearing lherzolite) which has experienced variable degrees of asthenospheric mantle-derived melt–peridotite interaction prior to melting. However, the Group 2 dykes were derived from an ancient garnet-facies phlogopite and/or amphibole-bearing lherzolite lithospheric mantle. Thinning of the Early Mesozoic lithospheric mantle beneath the northern NCC is dominantly through melt–peridotite interaction and thermo-mechanical erosion prior to Middle Jurassic time. The chemical compositions have been modified at the bottom of the lithospheric mantle through melt–peridotite interaction processes.
Carbon isotope perturbations and faunal changeovers during the Guadalupian mass extinction in the middle Yangtze Platform, South China
Authors: WEI HENGYE , BAIMA QUZONG , QIU ZHEN , DAI CHAOCHENG 
Published: June 2017

AbstractThe Guadalupian mass extinction took place during the major global environmental changes during Phanerozoic time. Large-scale sea-level fluctuations and a negative shift ofδ13C were associated with this crisis. However, the diagenetic or primary origin of the decreasedδ13C across the Guadalupian–Lopingian (G–L) boundary and the potential causes for this biotic crisis are still being intensely debated. Integrated analyses, including detailed petrographic examination, identification of foraminifer and fusulinid genera, and analysis of carbonateδ13Ccarband bulkδ13Corgacross the G–L boundary were therefore carried out at Tianfengping, Hubei Province, South China. Our results show that: (1) some foraminifer and most fusulinid genera disappear in the upper Maokou Formation (upper Guadalupian); (2) the negative shift ofδ13Ccarbin the uppermost Maokou Formation is of diagenetic origin, but the values ofδ13Ccarbin the remainder of the Maokou Formation and in the Wuchiaping Formation represent a primary signal of coeval seawater; and (3) the bulkδ13Corgperturbation across the G–L boundary at Tianfengping is mainly controlled by organic matter (OM) source, that is, terrestrial OM contribution. We suggest that theδ13Ccarbnegative shift in the lower Wuchiaping Formation (Wuchiapingian) compared to that in the lower–middle Maokou Formation (Capitanian) were probably caused by the re-oxidization of12C-rich OM during regression. Global regression resulted in the negative shift ofδ13Ccarbat the G–L boundary in South China and led to the loss of shallow-marine benthic habitat. Large-scale global regression is probably one of the main causes for this bio-crisis.
MEDIATION MODELS OF PREGNANCY DESIRES AND UNPLANNED PREGNANCY IN YOUNG, UNMARRIED WOMEN
Authors: Miller Warren B. , Barber Jennifer S. , Gatny Heather H. 
Published: June 2017

SummaryThis paper examines the proposition that sexual and contraceptive behaviours mediate the relationship between the pregnancy desires of young, unmarried women and their having an unplanned pregnancy. The sample consisted of 854 18- to 19-year-old women living in Michigan, USA. First, the positive and negative pregnancy desires of these women were measured, as were the women’s perceptions of the positive and negative desires of their sexual partners. Then the extent to which these four types of desires, as well as several types of interactions between them, prospectively predicted the occurrence of subsequent pregnancies were tested with logistic regression analyses, initially alone and then after the addition of several types of sexual and contraceptive mediator variables. The results demonstrated that four of the ten significant motivational predictors became non-significant following the introduction of the contraceptive mediator variables and that the predictive strength of the other six significant motivational predictors was substantially reduced by their introduction. A number of factors that may account for only a partial mediational effect in some models are discussed.
Univariate and multivariate models for the prediction of life-threatening complications in 586 cases of deep neck space infections: retrospective multi-institutional study
Authors: Mejzlik J , Celakovsky P , Tucek L , Kotulek M , Vrbacky A , Matousek P , Stanikova L , Hoskova T , Pazs A , Mittu P , Chrobok V 
Published: June 2017

AbstractObjective:To identify deep neck infection factors related to life-threatening complications.Methods:This retrospective multi-institutional study comprised 586 patients treated for deep neck infections between 2002 and 2012. The statistical significance of variables associated with life-threatening complications of deep neck infections was assessed.Results:During treatment, life-threatening complications occurred in 60 out of 586 cases. On univariate analysis, life-threatening complications were linked to: dyspnoea, neck movement disturbance and dysphonia (all p < 0.001); and parapharyngeal, anterior visceral or pretracheal deep neck involvement (all p < 0.002). Aetiology was significantly linked to tonsils (p < 0.001). Regarding infection type, fasciitis was a significant factor (p < 0.001). Candida albicans was a significant bacterial culture (p < 0.001). A multivariate step-wise model disclosed fewer significant variables: retropharyngeal space (p = 0.005) and major blood vessels area (p = 0.006) involvement, and bacterial culture C albicans (p < 0.001).Conclusion:It can be predicted that patients with deep neck infections, with neck movement disturbances, dysphonia, dyspnoea and swelling of the external neck, accompanied by severe pain, and inflammatory changes in the retropharyngeal space and large vessel areas, with culture-confirmed infection of C albicans, are likely to develop life-threatening complications.
Opium and Migration: Jardine Matheson's imperial connections and the recruitment of Chinese labour for Assam, 1834–39
Authors: NEAL STAN 
Published: June 2017

AbstractThis article examines the role of the private merchant firm Jardine Matheson in procuring Chinese tea cultivators for the East India Company's experimental tea plantations in Assam in the 1830s. Where existing literature has detailed the establishment of a Tea Committee by the East India Company to oversee these tea plantations, the focus of this article is on the way that the illicit opium-distribution network of Jardine Matheson was used to extract labour, tea specimens, and knowledge from China. The colonial state's experimental tea plantations were directly connected to the devastation of the opium trade. The multiple uses of Jardine Matheson's drug-distribution networks and skilled employees becomes evident upon examination of their role in facilitating Chinese migration. The recruitment of tea cultivators from China in the 1830s also impacted on colonial concepts of racial hierarchy and the perceived contrast between savagery and civilization. Ultimately, Jardine Matheson's extraction of skilled labour from the China coast informs our understanding of the evolving private networks that became crucial to British imperialism in Asia, and through which labour, capital, people, information, and ideas could be exchanged.
Applicability of plant-based products in the treatment ofTrypanosoma cruziandTrypanosoma bruceiinfections: a systematic review of preclinicalin vivoevidence
Authors: PEREIRA RODRIGO M. , GRECO GLÍCIA M. Z. , MOREIRA ANDREIA M. , CHAGAS PABLO F. , CALDAS IVO S. , GONÇALVES REGGIANI V. , NOVAES RÔMULO D. 
Published: June 2017

SUMMARYChagas disease and sleeping sickness are neglected tropical diseases closely related to poverty, for which the development of plant-derived treatments has not been a promising prospect. Thus, we systematicaly review the preclinicalin vivoevidence on the applicability of plant-based products in the treatment ofTrypanosoma cruziandTrypanosoma bruceiinfections. Characteristics such as disease models, treatments, toxicological safety and methodological bias were analysed. We recovered 66 full text articles from 16 countries investigating 91 plant species. The disease models and treatments were highly variable. Most studies used native (n= 36, 54·54%) or exotic (n= 30, 45·46%) plants with ethnodirected indication (n= 45, 68·18%) for trypanosomiasis treatment. Complete phytochemical screening and toxicity assays were reported in only 15 (22·73%) and 32 (48·49%) studies, respectively. The currently available preclinical evidence is at high risk of bias. The absence of or incomplete characterization of animal models, treatment protocols, and phytochemical/toxicity analyses impaired the internal validity of the individual studies. Contradictory results of a same plant species compromise the external validity of the evidence, making it difficult determine the effectiveness, safety and biotechnological potential of plant-derived products in the development of new anti-infective agents to treatT. cruziandT. bruceiinfections.
Genetic and environmental aspects in the association between attention-deficit hyperactivity disorder symptoms and binge-eating behavior in adults: a twin study
Authors: Capusan A. J. , Yao S. , Kuja-Halkola R. , Bulik C. M. , Thornton L. M. , Bendtsen P. , Marteinsdottir I. , Thorsell A. , Larsson H. 
Published: June 2017

BackgroundPrior research demonstrated that attention-deficit hyperactivity disorder (ADHD) is associated with binge-eating behavior, binge-eating disorder (BED), and bulimia nervosa (BN). The aim of this study was to investigate these associations in an adult twin population, and to determine the extent to which ADHD symptoms and binge-eating behavior share genetic and environmental factors.MethodsWe used self-reports of current ADHD symptoms and lifetime binge-eating behavior and associated characteristics from a sample of over 18 000 adult twins aged 20–46 years, from the population-based Swedish Twin Registry. Mixed-effects logistic regression was used to examine the association between ADHD and lifetime binge-eating behavior, BED, and BN. Structural equation modeling was used in 13 773 female twins to determine the relative contribution of genetic and environmental factors to the association between ADHD symptoms and binge-eating behavior in female adult twins.ResultsADHD symptoms were significantly associated with lifetime binge-eating behavior, BED, and BN. The heritability estimate for current ADHD symptoms was 0.42 [95% confidence interval (CI) 0.41–0.44], and for lifetime binge-eating behavior 0.65 (95% CI 0.54–0.74). The genetic correlation was estimated as 0.35 (95% CI 0.25–0.46) and the covariance between ADHD and binge-eating behavior was primarily explained by genetic factors (91%). Non-shared environmental factors explained the remaining part of the covariance.ConclusionsThe association between adult ADHD symptoms and binge-eating behavior in females is largely explained by shared genetic risk factors.
PHARMACOECONOMIC STUDIES IN WORLD HEALTH ORGANIZATION EASTERN MEDITERRANEAN COUNTRIES: REPORTING COMPLETENESS
Authors: Alefan Qais , Rascati Karen 
Published: June 2017

Objectives: The aim of this study was to evaluate the extent of reporting necessary information in published health economic research in World Health Organization Eastern Mediterranean Countries (WHO EMC).Methods: A systematic literature search was conducted using PubMed and Google Scholar to identify pharmacoeconomic studies conducted in WHO EMC. The inclusion criteria for the studies were: (i) original studies, (ii) compared pharmaceutical services or drugs, (iii) conducted in WHO EMC, (iv) manuscript published in English. The articles were reviewed by two independent reviewers using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist.Results: A total of seventeen studies were included, each of which were published in seventeen different journals. The mean CHEERS checklist score was 16 ± 4. Most studies were published in journals outside WHO EMC (n = 12; 71 percent). Cost-effectiveness (n = 5; 29 percent) and cost-utility analyses (n = 5; 29 percent) were the most frequently used methods of economic evaluation.Conclusions: Pharmacoeconomic studies in WHO EMC are limited and sometimes incomplete. Economic evaluation of pharmaceuticals should be encouraged in WHO EMC to ensure the appropriate allocation of healthcare resources.
HARMONIZING HEALTH TECHNOLOGY ASSESSMENT PRACTICES IN UNIVERSITY HOSPITALS: TO WHAT EXTENT IS THE MINI-HTA MODEL SUITABLE IN THE FRENCH CONTEXT?
Authors: Martelli Nicolas , Devaux Capucine , van den Brink Hélène , Billaux Mathilde , Pineau Judith , Prognon Patrice , Borget Isabelle 
Published: June 2017

Background: The number of new medical devices for individual use that are launched annually exceeds the assessment capacity of the French national health technology assessment (HTA) agency. This has resulted in hospitals, and particularly university hospitals (UHs), developing hospital-based HTA initiatives to support their decisions for purchasing innovative devices. However, the methodologies used in such hospitals have no common basis. The aim of this study was to assess a mini-HTA model as a potential solution to harmonize HTA methodology in French UHs.Methods: A systematic review was conducted on Medline, Embase, Health Technology Assessment database, and Google Scholar to identify published articles reporting the use of mini-HTA tools and decision support-like models. A survey was also carried out in eighteen French UHs to identify in-house decision support tools. Finally, topics evaluated in the Danish mini-HTA model and in French UHs were compared using Jaccard similarity coefficients.Results: Our findings showed differences between topics evaluated in French UHs and those assessed in decision support models from the literature. Only five topics among the thirteen most evaluated in French UHs were similar to those assessed in the Danish mini-HTA model. The organizational and ethical/social impacts were rarely explored among the surveyed models used in French UHs when introducing new medical devices.Conclusions: Before its widespread and harmonized use in French UHs, the mini-HTA model would first require adaptations to the French context.