bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary Arterial Compliance in Acute Respiratory Distress Syndrome: Clinical Determinants and Association With Outcome From the Fluid and Catheter Treatment Trial Cohort*
Authors: Metkus Thomas S. , Tampakakis Emmanouil , Mullin Christopher J. , Houston Brian A. , Kolb Todd M. , Mathai Stephen C. , Damico Rachel , Maron Bradley A. , Hassoun Paul M. , Brower Roy G. , Tedford Ryan J. 
Published: December 2016

Objectives:
Pulmonary vascular dysfunction is associated with adverse prognosis in patients with the acute respiratory distress syndrome; however, the prognostic impact of pulmonary arterial compliance in acute respiratory distress syndrome is not established.

Design, Setting, Patients:
We performed a retrospective analysis of 363 subjects with acute respiratory distress syndrome who had complete baseline right heart catheterization data from the Fluid and Catheter Treatment Trial to test whether pulmonary arterial compliance at baseline and over the course of treatment predicted mortality.

Main Results:
Baseline pulmonary arterial compliance (hazard ratio, 1.18 per interquartile range of 1/pulmonary arterial compliance; 95% CI, 1.02–1.37; p = 0.03) and pulmonary vascular resistance (hazard ratio, 1.28 per interquartile range; 95% CI, 1.07–1.53; p = 0.006) both modestly predicted 60-day mortality. Baseline pulmonary arterial compliance remained predictive of mortality when pulmonary vascular resistance was in the normal range (p = 0.02). Between day 0 and day 3, pulmonary arterial compliance increased in acute respiratory distress syndrome survivors and remained unchanged in nonsurvivors, whereas pulmonary vascular resistance did not change in either group. The resistance-compliance product (resistance-compliance time) increased in survivors compared with nonsurvivors, suggesting improvements in right ventricular load.

Conclusions:
Baseline measures of pulmonary arterial compliance and pulmonary vascular resistance predict mortality in acute respiratory distress syndrome, and pulmonary arterial compliance remains predictive even when pulmonary vascular resistance is normal. Pulmonary arterial compliance and right ventricular load improve over time in acute respiratory distress syndrome survivors. Future studies should assess the impact of right ventricular protective acute respiratory distress syndrome treatment on right ventricular afterload and outcome.
Developmental Trajectories of Bottle-Feeding During Infancy and Their Association with Weight Gain
Authors: Ventura Alison K. 
Published: December 2016

ABSTRACT:

Objective:
To describe patterns of bottle-feeding across the first year postpartum and explore whether bottle-feeding trajectories are differentially associated with infant weight gain.

Method:
Data came from 1291 mothers who participated in the Infant Feeding Practices Study 2. Mothers completed a prenatal questionnaire and monthly surveys of infant feeding and growth between birth and 12 months. Group-based trajectory mixture modeling was used to describe developmental trajectories of bottle-feeding intensities across the first year. Growth curve modeling was used to explore associations between bottle-feeding intensity trajectory group membership and weight-for-age z-score (WAZ) trajectories from birth to 12 months.

Results:
Four qualitatively distinct trajectories of bottle-feeding were identified: (1) High-Stable: ∼100% of feeds from bottles across infancy; (2) Rapid-Increase: <30% of feeds from bottles during the neonatal assessment, increasing to ∼100% by 6 months; (3) Gradual-Increase: <10% of feeds from bottles during the neonatal assessment, gradually increasing to ∼100% by 12 months; and (4) Low-Stable: <5% of feeds from bottles across the majority of infancy. Bottle-feeding groups had significantly different WAZ trajectories across infancy; by 12 months, the High-Stable and Rapid-Increase groups had significantly higher WAZs compared with the Gradual-Increase and Low-Stable groups (p < .001). The association between bottle-feeding group membership and WAZ trajectories was not confounded by sociodemographic characteristics or the extent to which infants received breast milk.

Conclusion:
High-intensity bottle use during early infancy may place infants at higher risk for excess weight gain. Supports and policies that help mothers delay high-intensity bottle use until later infancy are warranted.
An Appraisal of Internal Mammary Artery Perforators as Recipient Vessels in Microvascular Breast Reconstruction—An Analysis of 515 Consecutive Cases
Authors: Vollbach Felix H. , Heitmann Christoph D. , Fansa Hisham 
Published: December 2016

Background:
The usage of internal mammary artery perforators (IMAPs) has been described in autologous breast reconstruction although IMAPS are not yet considered standard recipient vessels. It remains unclear if these vessels can be safely used in large flaps after radiation therapy or in delayed breast reconstruction.

Methods:
Over a 2-year period, 515 free flaps for autologous breast reconstruction were performed on 419 patients by 2 surgeons (S1 and S2). In a retrospective analysis, time of reconstruction, ischemia time, flap weight, diameter of couplers, and complications were analyzed. All 515 flaps were compared in a subset with regard to the 2 surgeons: S1 who always used the IMA as a recipient vessel and S2 who attempted IMAP use if possible.

Results:
Of all 515 flaps, 424 were abdominal flaps and 91 flaps were from the upper thigh. Three hundred six cases were immediate reconstructions, and 112 were delayed reconstructions. In 97 cases, implants were converted to autologous tissue. In 112 cases, the IMAPs were used; of these, 82 were immediate and 17 were delayed reconstructions, and in 13 cases, implants were removed. Thirty-five percent of all anastomoses to IMAPs had previous radiation therapy. The flap failure rate was 1.9%. In none of these cases, the IMAPs were used. S1 never used the IMAP, and S2 used the IMAP in 37% of all of his flaps.

Conclusions:
IMAPs were safely used in all kinds of reconstructions and after radiation therapy, with no flap failure or negative effects on mastectomy skin flap perfusion. Using the IMAPs as recipient vessels is a further step toward simplifying microsurgical breast reconstruction.
CHANGE OF CHOROIDAL VOLUME IN UNTREATED CENTRAL SEROUS CHORIORETINOPATHY
Authors: Pertl Laura , Haas Anton , Hausberger Silke , Pichler Tamara , Rabensteiner Dieter F. , Seidel Gerald , Malle Eva M. , Weger Martin 
Published: December 2016

Purpose:
Choroidal hyperpermeability plays a central role in the pathophysiology of central serous chorioretinopathy (CSC). In active CSC undergoing treatment, choroidal thickness decreases if subretinal fluid (SRF) resolves. This study aimed to investigate the change in choroidal thickness and volume in eyes with untreated CSC.

Methods:
The authors retrospectively analyzed 27 eyes with treatment-naïve CSC (25 patients), who had a follow-up of 4 to 6 weeks. Retinal and choroidal volume and SRF were segmented manually and calculated using the Spectralis OCT built-in software (Spectralis; Heidelberg Engineering).

Results:
In treatment-naïve eyes with CSC, an increase in SRF was significantly associated with an increase in choroidal thickness and volume (rho = 0.93, P < 0.01). Eyes with greater baseline choroidal volume showed a significantly greater decrease in SRF during follow-up (rho = −0.47, P = 0.03).

Conclusion:
In this study, an increase in SRF was associated with an increase in both choroidal thickness and volume in eyes with treatment-naïve CSC. Eyes with thicker baseline choroidal volume showed a greater reduction in SRF.
SHORT-TERM EFFECTS OF EXERCISE ON OPTIC NERVE AND MACULAR PERFUSION MEASURED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
Authors: Alnawaiseh Maged , Lahme Larissa , Treder Maximilian , Rosentreter André , Eter Nicole 
Published: December 2016

Purpose:
To evaluate the effects of exercise on optic nerve and macular perfusion using optical coherence tomography angiography.

Methods:
Thirteen eyes of 13 healthy volunteers were examined using a high-speed and high-resolution spectral-domain optical coherence tomography XR Avanti with a split-spectrum amplitude-decorrelation angiography algorithm. Blood pressure, heart rate, the mean area of the foveal avascular zone , and flow density on the optic nerve head and macula, before and after exercise were measured and analyzed.

Results:
Mean patient age was 27.3 ± 3.5 years. Heart rate, systolic and diastolic blood pressure increased significantly after exercise (P < 0.001). The mean area of the foveal avascular zone did not change significantly after exercise (before: 0.27 ± 0.07 mm2; after: 0.26 ± 0.07 mm2; P = 0.10). The peripapillary and the parafoveal flow density decreased significantly after exercise (peripapillary: before: 65.1 ± 2.1; after: 62.3 ± 3.0; P < 0.001 and parafoveal: before: 56.7 ± 1.3; after: 55.6 ± 1.5; P = 0.007).

Conclusion:
Increased physical activity induced significant changes in optic nerve and macular perfusion, which were measured using split-spectrum amplitude-decorrelation angiography optical coherence tomography angiography. In studies that aim to evaluate optic nerve and macular perfusion using optical coherence tomography angiography, it should be strongly recommended that patients rest before imaging is performed and that data concerning systemic circulation including blood pressure and pulse is included within the evaluation.
A CASE OF FULL-THICKNESS MACULAR HOLE IN EYE WITH FOCAL CHOROIDAL EXCAVATION
Authors: Fayyad Omar Faisal , Al-Hashimi Mustafa Raad , Fayyad Faisal Tawfeeq 
Published: December 2016

Purpose:
To report an association between a Stage 4 full-thickness macular hole and focal choroidal excavation.

Methods:
Case report.

Results:
A 46-year-old male patient with high myopia was referred for macular hole surgery and found to have an associated focal choroidal excavation. The patient underwent uneventful combined procedure with closure of macular hole.

Conclusion:
Successful macular hole surgery can be achieved even in the presence of focal choroidal excavation.
Simbu Ptosis: An Outreach Approach to Myogenic Ptosis in Eastern Highlands of Papua New Guinea—Experience and Results From a High-Volume Oculoplastic Surgical Camp
Authors: Gushchin Anna G. , Crum Alison V. , Limbu Ben B. , Quigley Edward P. , Seward Michael S. , Tabin Geoffrey C. 
Published: December 2016

Purpose:
To present the results of a high-volume oculoplastic surgical outreach in a remote region of Simbu Province in the Eastern Highlands of Papua New Guinea. The authors describe the clinical features and evaluation and treatment of a novel ptosis syndrome found in this area.

Design:
A team of 4 international ophthalmologists and 3 local doctors and 3 local nurses involved in a high-volume field intervention for all patients presenting with a bilateral ptosis to Mingende Rural Hospital.

Methods:
Patients were systematically evaluated and treated during a 6-day surgical outreach and followed daily for 1 week and as needed via telemedicine. Visiting surgeons provided skills-transfer instruction for 3 local doctors and 3 nurses. Data collected included demographic information, history of present illness, past medical history, family history, social history, and a complete ophthalmologic and targeted neurologic evaluation. Patients were offered surgical intervention if they met criteria for safe eyelid elevation and could present for follow ups. Detailed notes of patient geographic location, history, and risk factors were collected in addition to pre- and postoperative photos.

Main outcome measures:
Efficient triage and treatment of all patients referred to the remote oculoplastic clinic.

Results:
A total of 97 patients presented to the camp; of these, 87 underwent complete evaluation. There were 72 patients with ptosis, of which 60 were found to be of Simbu-type. These patients were grouped clinically by degree of ptosis: mild, moderate, and severe. Thirty-eight patients had moderate ptosis of which 34 underwent surgical intervention. Eleven patients with mild ptosis were counseled and observed. The 10 patients with severe ptosis and 2 with moderate ptosis were treated medically with ptosis crutches manufactured on site. A new technique for creating ptosis crutch glasses was developed.

Conclusions:
A new variant of progressive myogenic ptosis was identified. A high-volume oculoplastic surgical camp is an efficient way to systematically evaluate and treat this new entity. Skills-transfer training for local doctors and staff ensured continuity of care for the surgical patients.
The Brow Fat Pad Suspension Suture: Safety Profile and Clinical Observations
Authors: Eftekhari Kian , Peng Grace L. , Landsberger Hannah , Douglas Raymond , Massry Guy G. 
Published: December 2016

Purpose:
To evaluate the safety, subjectively assess outcome, and emphasize surgical pearls and critical clinical observations of upper blepharoplasty performed in conjunction with the brow fat pad suspension suture procedure, previously referred to as a “browpexy variant” or “brassiere suture procedure.”

Methods:
A retrospective 4-year analysis of patients who underwent the brow fat pad suspension suture with upper blepharoplasty was performed. Adjunctive procedures (brow lift and ptosis repair) were categorized. The surgical technique is detailed with emphasis placed on nuances to aid in optimal outcome.

Results:
Two hundred and sixteen patients (149 women and 47 men) underwent upper blepharoplasty with the brow fat pad suspension suture. The average patient age is 54 years and follow up is 11 months. One hundred patients had adjudicative brow lift or ptosis repair, and in 20 patients the blepharoplasty was a revision procedure. Subjective assessment of outcome showed excellent aesthetic results with improved brow projection, and enhanced lateral tarsal platform show and eyebrow/eyelid contour. Surgical complications were infrequent and patient satisfaction was high.

Conclusions:
This initial large series description of the brow fat pad suspension suture demonstrates that it is a safe adjunct to upper blepharoplasty, which the authors believe subjectively improves overall outcome. Evidence-based quantitative assessments of objective measures of surgical results are currently underway.
Mycoplasma pneumoniae and Stevens-Johnson Syndrome
Authors: Álvarez Álvarez Nelly , Fernández-Luis Sheila , Sánchez-Villares Lorenzo Claudia , Roncero Toscano Mónica Lilian , Mendoza Sánchez María del Carmen 
Published: December 2016

Abstract
Stevens-Johnson syndrome is an uncommon mucocutaneous disease usually considered as severe drug reactions, and other different agents can take part in its etiopathogenesis, including infections such as the one caused by Mycoplasma pneumoniae. We describe the clinical evolution, diagnosis, and treatment of an 8-year-old boy with mucous injury associated to an infection by M. pneumoniae and present a review of all cases published in the last 8 years.
Abdominal compartment syndrome and the open abdomen: any unresolved issues?
Authors: Sugrue Michael 
Published: December 2016

Purpose of review
This article reviews the key principles of abdominal compartment syndrome and the open abdomen, exploring some of the unresolved issues. It reviews new concepts in care.

Recent findings
Recent use of peritoneal resuscitation, and benefits of mesh-mediated traction are discussed. Abdominal compartment syndrome remains a result of complex interaction between general haemorrhage, sepsis and fluid resuscitation. Improved resuscitation and sepsis control has decreased but not abolished the need for the open abdomen and progression for abdominal compartment syndrome. Fourth-generation abdominal wall dressings need to be combined with a dynamic closure system; currently, negative pressure wound therapy at the index open abdomen coupled with mesh-mediated tractions offers the best outcome.

Summary
The key to optimizing outcome is early abdominal closure within 7 days because failure to do so will increase morbidity, mortality and fistulae formation. Novel techniques complementing existing de-resuscitation techniques are discussed.
Endoscopic Ultrasound–guided Drainage of Walled‐off Necrosis in Children With Fully Covered Self‐expanding Metal Stents
Authors: Nabi Zaheer , Lakhtakia Sundeep , Basha Jahangeer , Chavan Radhika , Ramchandani Mohan , Gupta Rajesh , Kalapala Rakesh , Darisetty Santosh , Talukdar Rupjyoti , Reddy Duvuur Nageshwar 
Published: December 2016

ABSTRACTObjectives:Endoscopic ultrasound (EUS)‐guided drainage with fully covered self‐expanding metallic stents (FCSEMS) has been successfully used in adult patients. The utility of FCSEMS in children with walled‐off necrosis (WON) is, however, unknown. The aim of present study was to evaluate the feasibility, safety, and efficacy of EUS drainage of WON using FCSEMS in children.Methods:We retrospectively evaluated the data of children (18 years or younger) who underwent EUS drainage of WON using FCSEMS at our institution. All FCSEMS were removed between 1 and 3 months. Feasibility, safety, and efficacy were analysed.Results:Twenty‐one children (20 boys, mean age 14.9 ± 2.34 years, range 9–18 years) underwent EUS‐guided drainage of WON with FCSEMS. The median size of WON was 88 mm (55–148 mm). The median interval between onset of acute pancreatitis and EUS guided drainage was 58 days (range 30–288 days). The technical and clinical success rates were 100% and 95%, respectively. Nasocystic tube was placed in 3 children for lavage. Endoscopic necrosectomy was not required in any of the children. There were no major complications. Minor complications included bleeding (2), stent migration (1), and difficulty in removal of stent (1). After a median follow‐up of 360 days (range: 30–1020 days), there was 1 recurrence of WON.Conclusions:EUS drainage of WON using specially designed FCSEMS is safe and efficacious in children. The utility of FCSEMS in children should be further explored and compared with plastic stents.
A Comparison Study
Authors: Yoo Yang Gyeong , Yu Boas J. , Choi Eun-Hi 
Published: December 2016

Background:
In South Korea, there has been a rapid increase in thyroid cancer diagnoses, and the thyroid cancer incidence rate is the highest in the world. This study explored possible risk factors that may influence the development of thyroid cancer by comparing life habits of thyroid cancer patients and healthy adults.

Objective:
The aims of this study were to identify lifestyle and habit differences in thyroid cancer patients and healthy adults and to investigate risk factors that influence the development of thyroid cancer.

Methods:
The study was designed as a retrospective comparison survey study of thyroid cancer patient group and healthy adult group. One hundred two thyroid cancer patients in a university hospital and 115 healthy adults were recruited for this study. Data were analyzed using descriptive statistics, χ
2 test/t test, and logistic regression with SPSS program.

Results:
Previous smoking history, lower physical activity level, higher stress, and unhealthy eating habits (consumption of instant food products) were shown to be risk factors in the development of thyroid cancer.

Conclusion:
Based on the results of this study comparing thyroid cancer patients and healthy adults, it is recommended to encourage an increase in physical activity, minimize both direct and indirect exposure to smoking, develop healthy eating habits of consuming more vegetables, and effectively manage stress levels.

Implications for Practice:
Lifestyle preferences and habits may influence the development of thyroid cancer. It is imperative to identify and modify the risk factors in order to prevent thyroid cancer development.
Cancer Survivors’ Experiences and Explanations of Postcancer Fatigue
Authors: Watson Amy , van Kessel Kirsten 
Published: December 2016

Background:
Postcancer fatigue (PCF) is a form of chronic fatigue that is very common and can persist for years among disease-free cancer survivors. Despite this, PCF remains underreported and often goes untreated.

Objective:
The aim of this study is to explore PCF from the perspective of cancer survivors via online blogs, with a focus on their experiences and personal explanations of PCF.

Methods:
An online search identified 15 recent blogs written by cancer survivors who specifically discussed their PCF. Thematic analysis was used to analyze blog content.

Results:
Bloggers explained PCF as a severe and unpredictable symptom in their lives. They identified anxiety, emotional trauma, and cancer side effects to be the key causal factors of their PCF. Coping strategies adopted by bloggers included diet, exercise, acceptance and reducing workload to manage their fatigue.

Conclusions:
Online blogs are a rich source of qualitative data that can give unique insight into issues faced by cancer survivors. Bloggers’ accounts confirmed that PCF is a complex issue that can be a significant source of frustration in their everyday lives. This study highlighted that bloggers with PCF appear to have some coping strategies and understanding of PCF, yet these are not always consistent with current medical and psychological knowledge.

Implications for Practice:
This study has demonstrated that blogs can offer valuable information to existing knowledge of cancer survivors’ experiences and explanations of PCF. The findings may assist healthcare professionals with educating patients about PCF and with increasing the legitimacy, awareness, and understanding of PCF.
Performance of 4 Immunohistochemical Phosphohistone H3 Antibodies for Marking Mitotic Figures in Breast Cancer
Authors: Focke Cornelia M. , Finsterbusch Kai , Decker Thomas , van Diest Paul J. 
Published: December 2016

Background:
Phosphohistone H3 (PHH3) has been suggested to facilitate and improve mitotic activity assessment in breast cancer and other tumor entities, but the reliability of respective immunohistochemical antibodies has not yet been compared for routine purposes. Our aim was to test the performance of 4 different PHH3 antibodies on a series of highly proliferating breast cancers with good preservation of morphology.

Methods:
Four commercially available PHH3 antibodies were tested on 9 grade 3 invasive breast cancers processed in the same batch. We analyzed the number of antibody stained and nonstained mitotic figures as well as the total of cells observed in 10 high power fields per tumor to calculate sensitivity, specificity, and accuracy of the respective antibodies for staining mitotic figures, taking morphologically defined mitotic figures as gold standard.

Results:
Sensitivity, specificity, and accuracy of the respective PHH3 antibodies for staining mitotic figures were 54.51%, 99.98%, and 98.79% for Cell Marque, 87.48%, 67.62%, and 67.47% for Epitomics, 98.62%, 99.73%, and 99.49% for Merck 06-570, and 99.74%, 99.52%, and 99.51% for Merck 09-797, respectively. Sensitivity was lowest for telophase. In statistical analysis, the Cell Marque antibody demonstrated significantly lower sensitivity and Epitomics substantially lower sensitivity and specificity than Merck 06-570 and Merck 09-797 antibodies (P<0.0001, respectively).

Conclusions:
Performance and reliability varied significantly between the 4 tested antibodies. For faster identification of mitotic hot spots and as potential marker in digital image analysis, the Merck antibodies seem to be most suitable.