bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients with advanced cancer and depression report a significantly higher symptom burden than non-depressed patients
Authors: Grotmol Kjersti Støen , Lie Hanne C. , Loge Jon Håvard , Aass Nina , Haugen Dagny Faksvåg , Stone Patrick C. , Kaasa Stein , Hjermstad Marianne Jensen 
Published: January 2018

AbstractObjectiveClinical observations indicate that patients with advanced cancer and depression report higher symptom burden than nondepressed patients. This is rarely examined empirically. Study aim was to investigate the association between self-reported depression disorder (DD) and symptoms in patients with advanced cancer controlled for prognostic factors.MethodThe sample included 935 patients, mean age 62, 52% males, from an international multicentre observational study (European Palliative Care Research Collaborative – Computerised Symptom Assessment and Classification of Pain, Depression and Physical Function). DD was assessed by the Patient Health Questionnaire-9 and scored with Diagnostic and Statistical Manual of Mental Disorder-5 algorithm for major depressive disorder, excluding somatic symptoms. Symptom burden was assessed by summing scores on somatic Edmonton Symptom Assessment Scale (ESAS) symptoms, excluding depression, anxiety, and well-being. Item-by-item scores and symptom burden of those with and without DD were compared using nonparametric Mann-WhitneyUtests. The relative importance of sociodemographic, medical, and prognostic factors and DD in predicting symptom burden was assessed by hierarchical, multiple regression analyses.ResultPatients with DD reported significantly higher scores on ESAS items and a twofold higher symptom burden compared with those without. Factors associated with higher symptom burden were as follows. Diagnosis: lung (β= 0.15,p< 0.001) or breast cancer (β= 0.08,p< 0.05); poorer prognosis: high C-reactive protein (β= 0.08,p< 0.05), lower Karnofsky Performance Status (β= −0.14,p< 0.001), and greater weight loss (β= −0.15,p< 0.001); taking opioids (β= 0.11,p< 0.01); and having DD (β= 0.23,p< 0.001). The full model explained 18% of the variance in symptom burden. DD explained 4.4% over and above that explained by all the other variables.Significance of resultsDepression in patients with advanced cancer is associated with higher symptom burden. These results encourage improved routines for identifying and treating those suffering from depression.
A new model for fetal programming: maternal Ramadan-type fasting programs nephrogenesis
Authors: Mohany M. , Ashton N. , Harrath A. H. , Nyengaard J. R. , Alomar S. Y. , Alwasel S. 
Published: January 2018

AbstractThe effect of maternal Ramadan-type fasting (RTF) on the outcome of pregnancy, kidney development and nephron number in male rat offspring was investigated in current study. Pregnant rats were given food and waterad libitumduring pregnancy (control) or restricted for 16 h per day (RTF). Kidney structure was examined during fetal life, at birth, and in early and late adulthood. Maternal body weight, food intake, relative food intake and plasma glucose levels were significantly lower (P<0.001) in the RTF group. Litter and pup weights also were significantly lower (P<0.05) in the RTF group at birth, with no difference in the litter size. The RTF group had a longer gestation, delayed nephrogenesis with less well-differentiated glomeruli, more connective tissue, fewer medullary rays, an increase in the nephrogenic zone/cortical zone ratio, and significant increase (P<0.001) in kidney apoptosis at birth. On the other hand, maternal fasting reduced nephron number (by ~31%) with unchanged kidney and total glomerular volumes. Mean glomerular volume was significantly higher in RTF offspring. Assessment of renal structure revealed mild glomerulosclerosis with enlarged lobulated glomeruli in the renal cortex and high interstitial fibrosis in the medulla of RTF kidneys. Taken together, gestational fasting delays nephrogenesis and reduces nephron number in the kidneys of the offspring, that could be partially owing to increased apoptosis.
Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
Authors: Meng Xianyi , Grötsch Bettina , Luo Yubin , Knaup Karl Xaver , Wiesener Michael Sean , Chen Xiao-Xiang , Jantsch Jonathan , Fillatreau Simon , Schett Georg , Bozec Aline 
Published: January 2018

AbstractHypoxia-inducible factors (HIFs) are key elements for controlling immune cell metabolism and functions. While HIFs are known to be involved in T cells and macrophages activation, their functions in B lymphocytes are poorly defined. Here, we show that hypoxia-inducible factor-1α (HIF-1α) contributes to IL-10 production by B cells. HIF-1α regulates IL-10 expression, and HIF-1α-dependent glycolysis facilitates CD1dhiCD5+ B cells expansion. Mice with B cell-specific deletion of Hif1a have reduced number of IL-10-producing B cells, which result in exacerbated collagen-induced arthritis and experimental autoimmune encephalomyelitis. Wild-type CD1dhiCD5+ B cells, but not Hif1a-deficient CD1dhiCD5+ B cells, protect recipient mice from autoimmune disease, while the protective function of Hif1a-deficient CD1dhiCD5+ B cells is restored when their defective IL-10 expression is genetically corrected. Taken together, this study demonstrates the key function of the hypoxia-associated transcription factor HIF-1α in driving IL-10 expression in CD1dhiCD5+ B cells, and in controlling their protective activity in autoimmune disease.
Anisotropic sensor and memory device with a ferromagnetic tunnel barrier as the only magnetic element
Authors: Lόpez-Mir L. , Frontera C. , Aramberri H. , Bouzehouane K. , Cisneros-Fernández J. , Bozzo B. , Balcells L. , Martínez B. 
Published: January 2018

AbstractMultiple spin functionalities are probed on Pt/La2Co0.8Mn1.2O6/Nb:SrTiO3, a device composed by a ferromagnetic insulating barrier sandwiched between non-magnetic electrodes. Uniquely, La2Co0.8Mn1.2O6 thin films present strong perpendicular magnetic anisotropy of magnetocrystalline origin, property of major interest for spintronics. The junction has an estimated spin-filtering efficiency of 99.7% and tunneling anisotropic magnetoresistance (TAMR) values up to 30% at low temperatures. This remarkable angular dependence of the magnetoresistance is associated with the magnetic anisotropy whose origin lies in the large spin-orbit interaction of Co2+ which is additionally tuned by the strain of the crystal lattice. Furthermore, we found that the junction can operate as an electrically readable magnetic memory device. The findings of this work demonstrate that a single ferromagnetic insulating barrier with strong magnetocrystalline anisotropy is sufficient for realizing sensor and memory functionalities in a tunneling device based on TAMR.
A deep study of the protection of Lithium Cobalt Oxide with polymer surface modification at 4.5 V high voltage
Authors: Yang ZhiXiong , Li RenGui , Deng ZhengHua 
Published: January 2018

AbstractCharging the cells above a conventional voltage of 4.2 V is a promising attempt to increase the energy density of Lithium Cobalt Oxide (LCO), however, the problem of crystal instability at high voltage that leading deterioration of cycle performance needs to be urgently resolved. In this work, as an effective and easy approach to improve the cycle performance and crystal stability of LCO cycling at 4.5 V high voltage, we demonstrate direct surface modification of a LCO cathode by poly [N,N-bis(2-cryano-ethyl)-acrylamide]. The results of SEM, TEM and XRD all indicate that the crystal structure of polymer coating LCO remains unchanged after cycling at 4.5 V high voltage for 60 times. Furthermore, the XPS study of valence of cobalt on the surface of LCO demonstrates that cobaltic ion of polymer coating LCO can be reduced to cobaltous ion after charging the cell. Thus, the activity of the crystal surface can be weakened, as a result, the stability is improved, leading to the performance improvement.
MiRNA-seq-based profiles of miRNAs in mulberry phloem sap provide insight into the pathogenic mechanisms of mulberry yellow dwarf disease
Authors: Gai Ying-Ping , Zhao Huai-Ning , Zhao Ya-Nan , Zhu Bing-Sen , Yuan Shuo-Shuo , Li Shuo , Guo Fang-Yue , Ji Xian-Ling 
Published: January 2018

AbstractA wide range of miRNAs have been identified as phloem-mobile molecules that play important roles in coordinating plant development and physiology. Phytoplasmas are associated with hundreds of plant diseases, and the pathogenesis involved in the interactions between phytoplasmas and plants is still poorly understood. To analyse the molecular mechanisms of phytoplasma pathogenicity, the miRNAs profiles in mulberry phloem saps were examined in response to phytoplasma infection. A total of 86 conserved miRNAs and 19 novel miRNAs were identified, and 30 conserved miRNAs and 13 novel miRNAs were differentially expressed upon infection with phytoplasmas. The target genes of the differentially expressed miRNAs are involved in diverse signalling pathways showing the complex interactions between mulberry and phytoplasma. Interestingly, we found that mul-miR482a-5p was up-regulated in the infected phloem saps, and grafting experiments showed that it can be transported from scions to rootstock. Based on the results, the complexity and roles of the miRNAs in phloem sap and the potential molecular mechanisms of their changes were discussed. It is likely that the phytoplasma-responsive miRNAs in the phloem sap modulate multiple pathways and work cooperatively in response to phytoplasma infection, and their expression changes may be responsible for some symptoms in the infected plants.
Three-dimensional simulations of the interaction between the nova ejecta, accretion disk, and companion star
Authors: Figueira Joana , José Jordi , García-Berro Enrique , Campbell Simon W. , García-Senz Domingo , Mohamed Shazrene 
Published: January 2018

Context.Classical novae are thermonuclear explosions hosted by accreting white dwarfs in stellar binary systems. Material piles up on top of the white dwarf star under mildly degenerate conditions, driving a thermonuclear runaway. The energy released by the suite of nuclear processes operating at the envelope, mostly proton-capture reactions andβ+-decays, heats the material up to peak temperatures ranging from 100 to 400 MK. In these events, about 10−3–10−7M⊙, enriched in CNO and, sometimes, other intermediate-mass elements (e.g., Ne, Na, Mg, and Al) are ejected into the interstellar medium.Aims.To date, most of the efforts undertaken in the modeling of classical nova outbursts have focused on the early stages of the explosion and ejection, ignoring the interaction of the ejecta, first with the accretion disk orbiting the white dwarf and ultimately with the secondary star.Methods.A suite of 3D, smoothed-particle hydrodynamics (SPH) simulations of the interaction between the nova ejecta, accretion disk, and stellar companion were performed to fill this gap; these simulations were aimed at testing the influence of the model parameters—that is, the mass and velocity of the ejecta, mass and the geometry of the accretion disk—on the dynamical and chemical properties of the system.Results.We discuss the conditions that lead to the disruption of the accretion disk and to mass loss from the binary system. In addition, we discuss the likelihood of chemical contamination of the stellar secondary induced by the impact with the nova ejecta and its potential effect on the next nova cycle.
Nonradial and nonpolytropic astrophysical outflows
Authors: Chantry L. , Cayatte V. , Sauty C. , Vlahakis N. , Tsinganos K. 
Published: January 2018

Context. High-resolution radio imaging of active galactic nuclei (AGN) has revealed that the jets of some sources present superluminal knots and transverse stratification. Recent observational projects, such as ALMA and γ-ray telescopes, such as HESS and HESS2 have provided new observational constraints on the central regions of rotating black holes in AGN, suggesting that there is an inner- or spine-jet surrounded by a disk wind. This relativistic spine-jet is likely to be composed of electron-positron pairs extracting energy from the black hole and will be explored by the future γ-ray telescope CTA.
Aims. In this article we present an extension to and generalization of relativistic jets in Kerr metric of the Newtonian meridional self-similar mechanism. We aim at modeling the inner spine-jet of AGN as a relativistic light outflow emerging from a spherical corona surrounding a Kerr black hole and its inner accretion disk.
Methods. The model is built by expanding the metric and the forces with colatitude to first order in the magnetic flux function. As a result of the expansion, all colatitudinal variations of the physical quantities are quantified by a unique parameter. Unlike previous models, effects of the light cylinder are not neglected.
Results. Solutions with high Lorentz factors are obtained and provide spine-jet models up to the polar axis. As in previous publications, we calculate the magnetic collimation efficiency parameter, which measures the variation of the available energy across the field lines. This collimation efficiency is an integral part of the model, generalizing the classical magnetic rotator efficiency criterion to Kerr metric. We study the variation of the magnetic efficiency and acceleration with the spin of the black hole and show their high sensitivity to this integral.
Conclusions. These new solutions model collimated or radial, relativistic or ultra-relativistic outflows in AGN or γ-ray bursts. In particular, we discuss the relevance of our solutions to modeling the M 87 spine-jet. We study the efficiency of the central black hole spin to collimate a spine-jet and show that the jet power is of the same order as that determined by numerical simulations.
Intercultural Hands on Projects – Experiences in Architectural Education in Asian and European Context
Authors: Hackel Marcus , Gaube Andrea , Lampe MA Sabrina 
Published: January 2018

The duties of German architects include the indepth design process as well as a thorough quality supervision during the construction process with the goal of the “build success“. They are reflected in the “Hands on Projects” organized by German Universities. The best results and broadest findings come out of international and interdisciplinary cooperation and projects with participants coming from the diverse cultural background and even integrating refugees into these projects.
Students get in touch with different philosophies, attitudes, values, and approaches. They learn about intercultural communication and develop unique solutions. Different social and cultural background leads to different behavior. Not being aware of the cultural differences may lead to misunderstanding and irritation. Analysing the cause of these misunderstandings and getting knowledge about the cultural influence on architectural planning, communication and problem solving is one of the mayors tasks of these intercultural and interdisciplinary projects.
Two case studies from Thailand and Germany published in this paper show different experiences with intercultural and interdisciplinary “Hands on Projects”.
Sustainable Customized Consolidation Design of Kuin Riverside Kampong Regeneration in Banjarmasin, Indonesia
Authors: Prayitno Budi 
Published: January 2018

On the one hand, the hyper-urbanization phenomenon gives numerous advancements in urban living quality, yet on the other hand, it also raises an equal amount of problems. Environmental issues come in the form of density issues, the existence of slums, floods, social inequality, and urban architectural identity. As a city with “City of a Thousand Rivers” as its brand, Banjarmasin now faces a shift in an urban architectural image from a river based city to a land-based city due to the rapid land-based infrastructure development. This resulted in the degradation of environmental and architectural quality of river-based village (kampong) settlement, the main component of Banjarmasin river front city, due to a strong paradigm shift. Kuin, a river side residential area/riverside tourist destination that is currently experiencing a degradation of environmental quality and place identity, is undergoing an urban renewal. Unfortunately, the policy approaches to urban planning that has been implemented are based on general formal guidelines; guidelines which do not take the informal nature of kampong river-side settlements, due to the lack of guidelines based on riverside place identity. This paper aims to explore the characteristics of riverside settlement using architectural image observation method, space syntax method for analyzing settlement configuration genotype, connectivity, interface and interlink territory integration, as well as questionnaire and interview methods to assess the perceptions of residents and municipal authorities. From the results of this research, five compositions forms have been identified: attachment to riverside settlement identity in the form of pilling, spanning, floating, embracing, and ascending with elements such as waterfront alleys, jukung (traditional boat), lanting (floating houses) as well as floating traditional markets that serves as the frame to the configuration. The identification process is done by using the approach of observing the spaceuse appropriation and the space-user perception on how to consider its sustainability aspect as a means to determine a level of adjustment. The result shows that self organized and self customized kampong residents and tourist are aware towards the river environment, the assets of local floating markets as well as the local social space. On the other hand, municipal authorities gave more attention to formal normative and regulative aspects. This analysis is used as the basis for recommendations for kampong riverside settlement design consolidation, which is done through guided participatory design workshops.
The result of this study is constructed as a concept for urban riverfront composition architecture, amphibious space territory, and urban riverfront settlement identity and expected to be able to further advance the knowledge surrounding the subject of urbanism and territoriality.
The Relationship Between Spatial Configuration and Social Interaction in High-Rise Flats: A Case Study On The Jatinegara Barat in Jakarta.
Authors: Ridwana Rifan , Prayitno Budi , Utomo Hatmoko Adi 
Published: January 2018

The construction of high-rise flats to minimize urban slum areas in Indonesia still create space use behavior problems for its residents due to the changes of space configuration between high-rise landed housing. Conventional high-rise flats cannot well accommodate the needs of social interactions happened in landed housing because of its spatial limitation that leads to uncertainty of space use behavior settings. This study aims to understand the relationship between spatial configuration on high-rise flats and social interaction levels of its residents. The object of study is Jatinegara Barat high-rise flats built to relocate slums community from the landed housing in Kampong Pulo. This study applies mix method research using space syntax method to analyze spatial configuration by looking at connectivity and space integration values, and then comparing it with social interaction data from place centered observation to find out the level of interaction and spaces tendency used interaction place.
The results of this study indicate that: (1) the relationship of spatial configuration to social interaction level in Jatinegara Barat flats can be positive or negative. (2) Positive relationships are found on the1st and 2ndfloor areas. High configuration values with high interaction levels are found in shared spaces on the 1st and 2nd floors with characteristics such as open space, large space, and availability of interaction supporting elements, while low configuration values with low interaction levels are found in more confined spaces such as private spaces and narrow corridors. (3) Negative relationships are found in the corridor and shared space in front of the elevator on each typical floors. Shared space in front of the elevator that has high spatial configuration value with large area show a low level of social interaction. While corridor with lower configuration value with the narrow area but have supporting elements such as chairs, mats, and shops have a higher level of social interaction. (4) This study shows that in the case of the relationship between spatial configuration and social interaction, availability of interaction supporting elements has greater influence rather than any other spatial factors.
Rectal Atresia and Congenital Hypothyroidism: An Association or Coincidence?
Authors: Mehmetoğlu Feride 
Published: January 2018

AbstractRectal atresia is a rare anorectal malformation, and its association with other anomalies is even more rare. This study presents a unique case of co-twin in which the surviving newborn male underwent surgery due to rectal atresia. Newborn screening tests identified congenital hypothyroidism. The surgical treatment consisted of three stages and thyroid hormones were replaced.
Prevalence and Risk Factors of Acute Pulmonary Embolism in Patients with Lung Cancer Surgery
Authors: Li Yu-ping , Shen Lei , Huang Wei , Hu Xue-fei , Xie Dong , Yang Jian , Song Xiao , Zhao Yan-feng , Zhou Chao-jie , Jiang Ge-ning 
Published: January 2018

AbstractAcute pulmonary embolism (PE) is one of the serious complications with high mortality after thoracic surgery. The authors aimed to determine the prevalence of PE events and evaluate additional risk factors for PE in patients with lung cancer surgery. Patients underwent lung cancer resections during January 2012 to July 2015 and had 30-day postoperative follow-up were included. Those with incomplete or miscoded data were excluded. The number of postoperative PE events was recorded retrospectively. Analyses were used to evaluate risk factors of PE during the hospitalization. The authors reviewed 11,474 patients who underwent surgery for lung cancer. The overall 30-day incidence of PE after thoracic surgery at their institution was 0.53%. The 30-day PE incidence without chemical prophylaxis was 0.57% (55/9,726) and the mortality rate was 10%. Multivariate analyses revealed that age over 66 (odds ratio [OR]: 1.09, 95% confidence interval [CI]: 1.05–1.12, p < 0.001), more extensive surgery than lobectomy (OR: 2.34, 95% CI: 1.28–4.25, p = 0.006) and stage IV of lung cancer (OR: 4.22, 95% CI: 1.50–11.9, p = 0.007) were associated with an increased risk of PE. Using these additional risk factors, based on readily available clinical characteristics, can help to risk-stratify patients and warrant extended chemical prophylaxis for patients to reduce the incidence of acute PE.
Laparoscopic Finding of Ectopic Adrenocortical Tissue in a 2-Year-Old Boy with Vanishing Testis
Authors: Marte Antonio 
Published: January 2018

AbstractEctopic adrenocortical tissue (EAT) along the spermatic cord is an unusual condition in children. The author reports on a 2-year-old boy with impalpable testis. On laparoscopy, EAT was detected along the hypotrophic spermatic vessels and excised. These remnants should be removed to prevent hormone production or malignant transformation.
Simulation als Fortbildungsmethode zur Professionalisierung von Teams
Authors: Flentje Markus , Eismann Hendrik , Sieg Lion , Friedrich Lars , Breuer Georg 
Published: January 2018

ZusammenfassungSimulation ist eine Methode, virtuelle Lernumgebungen zu erzeugen. Mittels Simulation können Technical Skills, aber auch Soft Skills wie die Funktionsfähigkeit von Teams sehr gut vermittelt werden. Dieser Team-Aspekt wird nachfolgend vor dem Hintergrund spezifischer Trainingsmethoden näher beleuchtet. Der Artikel bezieht sich dabei auf „Zwischenfalltrainings“, die in den Zentren der Autoren einen großen Anteil des Kursangebotes einnehmen.