bluuebunny/crossref_metadata_2025_split huggingface dataset:
ОЦІНКА ЕФЕКТИВНОСТІ ЛІКУВАННЯ АРТЕРІАЛЬНОЇ ГІПЕРТЕНЗІЇ ЗА ДАНИМИ ФАРМАКОЕПІДЕМІОЛОГІЧНОГО ТА ФАРМАКОЕКОНОМІЧНОГО АНАЛІЗУ
Authors: Vinnikova N. V. 
Published: March 2017

Метою даного дослідження було оцінити на основі ретроспективного фармакоепідеміологічного аналізу ефективність лікування артеріальної гіпертензії, дати фармакоекономічну оцінку антигіпертензивних лікарських засобів, розробити шляхи оптимізації антигіпертензивної терапії у хворих в лікарняних закладах охорони здоров’я.
ОСОБЛИВОСТІ РОЗВИТКУ ПРОФЕСІЙНО ВАЖЛИВИХ ПСИХОЛОГІЧНИХ ЯКОСТЕЙ МАЙБУТНІХ МЕДИЧНИХ СЕСТЕР
Authors: Zadyraka L. V. 
Published: March 2017

У статті наведено психолого-педагогічні чинники впливу на професійну та особистісну підготовку майбутніх медичних сестер і надані методичні рекомендації, спрямовані на розвиток їх професійно важливих психологічних якостей.
A Unified Theory of Neuro-MRI Data Shows Scale-Free Nature of Connectivity Modes
Authors: Galinsky Vitaly L. , Frank Lawrence R. 
Published: March 2017

A primary goal of many neuroimaging studies that use magnetic resonance imaging (MRI) is to deduce the structure-function relationships in the human brain using data from the three major neuro-MRI modalities: high-resolution anatomical, diffusion tensor imaging, and functional MRI. To date, the general procedure for analyzing these data is to combine the results derived independently from each of these modalities. In this article, we develop a new theoretical and computational approach for combining these different MRI modalities into a powerful and versatile framework that combines our recently developed methods for morphological shape analysis and segmentation, simultaneous local diffusion estimation and global tractography, and nonlinear and nongaussian spatial-temporal activation pattern classification and ranking, as well as our fast and accurate approach for nonlinear registration between modalities. This joint analysis method is capable of extracting new levels of information that is not achievable from any of those single modalities alone. A theoretical probabilistic framework based on a reformulation of prior information and available interdependencies between modalities through a joint coupling matrix and an efficient computational implementation allows construction of quantitative functional, structural, and effective brain connectivity modes and parcellation. This new method provides an overall increase of resolution, accuracy, level of detail, and information content and has the potential to be instrumental in the clinical adaptation of neuro-MRI modalities, which, when jointly analyzed, provide a more comprehensive view of a subject’s structure-function relations, while the current standard, wherein single-modality methods are analyzed separately, leaves a critical gap in an integrated view of a subject’s neuorphysiological state. As one example of this increased sensitivity, we demonstrate that the jointly estimated structural and functional dependencies of mode power follow the same power law decay with the same exponent.
Nowcasting Foehn Wind Events Using the AdaBoost Machine Learning Algorithm
Authors: Sprenger Michael , Schemm Sebastian , Oechslin Roger , Jenkner Johannes 
Published: March 2017

Abstract
The south foehn is a characteristic downslope windstorm in the valleys of the northern Alps in Europe that demands reliable forecasts because of its substantial economic and societal impacts. Traditionally, a foehn is predicted based on pressure differences and tendencies across the Alpine ridge. Here, a new objective method for foehn prediction is proposed based on a machine learning algorithm (called AdaBoost, short for adaptive boosting). Three years (2000–02) of hourly simulations of the Consortium for Small-Scale Modeling’s (COSMO) numerical weather prediction (NWP) model and corresponding foehn wind observations are used to train the algorithm to distinguish between foehn and nonfoehn events. The predictors (133 in total) are subjectively extracted from the 7-km COSMO reanalysis dataset based on the main characteristics of foehn flows. The performance of the algorithm is then assessed with a validation dataset based on a contingency table that concisely summarizes the cooccurrence of observed and predicted (non)foehn events. The main performance measures are probability of detection (88.2%), probability of false detection (2.9%), missing rate (11.8%), correct alarm ratio (66.2%), false alarm ratio (33.8%), and missed alarm ratio (0.8%). To gain insight into the prediction model, the relevance of the single predictors is determined, resulting in a predominance of pressure differences across the Alpine ridge (i.e., similar to the traditional methods) and wind speeds at the foehn stations. The predominance of pressure-related predictors is further established in a sensitivity experiment where ~2500 predictors are objectively incorporated into the prediction model using the AdaBoost algorithm. The performance is very similar to the run with the subjectively determined predictors. Finally, some practical aspects of the new foehn index are discussed (e.g., the predictability of foehn events during the four seasons). The correct alarm rate is highest in winter (86.5%), followed by spring (79.6%), and then autumn (69.2%). The lowest rates are found in summer (51.2%).
The phraseological dimension in interlanguage complexity research
Authors: Paquot Magali 
Published: March 2017

This article reports on the first results of a large-scale research programme that aims to define and circumscribe the construct of phraseological complexity and to theoretically and empirically demonstrate its relevance for second language theory. Within this broad agenda, the study has two main objectives. First, it investigates to what extent measures of phraseological complexity can be used to describe second language (L2) performance at different proficiency levels. Second, it compares measures of phraseological complexity with traditional measures of syntactic and lexical complexity. Variety and sophistication are postulated to be the first two dimensions of phraseological complexity, which is approached via relational co-occurrences, i.e. co-occurring words that appear in a specific structural or syntactic relation (e.g. adjective + noun, adverbial modifier + verb, verb + direct object). Phraseological diversity is operationalized as root type–token ratio computed for each syntactic relation. Two methods are tested to approach phraseological sophistication. First, sophisticated word combinations are defined as academic collocations that appear in the Academic Collocation List (Ackermann and Chen, 2013). Second, it is approximated with the average pointwise mutual information score as this measures has been shown to bring out word combinations made up of closely associated medium to low-frequency (i.e. advanced or sophisticated) words. The study reveals that unlike traditional measures of syntactic and lexical complexity, measures of phraseological sophistication can be used to describe L2 performance at the B2, C1 and C2 levels of the Common European Framework of References for Languages (CEFR), thus suggesting that essential aspects of language development from upper-intermediate to very advanced proficiency level may be situated in the phraseological dimension.
Global longitudinal strain from resting echocardiogram is associated with long-term adverse cardiac outcomes in patients with suspected coronary artery disease
Authors: Yadlapati Ajay , Maher Timothy R. , Thomas James D. , Gajjar Mark , Ogunyankin Kofo O. , Puthumana Jyothy J. 
Published: March 2017

Purpose: Measuring myocardial strain using two-dimensional speckle tracking echocardiography has emerged as a new tool to identify subclinical ventricular dysfunction. Abnormal strain has been shown to have superior sensitivity compared with dobutamine stress echocardiography for viability assessment; however, there is a paucity of data regarding the prediction of long-term major adverse cardiac events. We compared the prognostic ability of both global longitudinal strain (GLS) from resting echocardiograms to regional wall motion score index (WMSI) from stress echocardiograms in their ability to predict long-term major adverse cardiac events. Methods: Patients referred for stress echocardiography, who also underwent coronary angiography within 3 months of stress echo (n=122), were enrolled. Patients with reduced ejection fractions (<40%) were excluded. Patients were followed for a median of 3.4 years for major adverse cardiac events, readmissions and repeat cardiac testing. Results: Patients with abnormal GLS (GLS <16.8%) from the resting echocardiogram obtained as part of the exercise echocardiogram experienced a significantly shorter time to major adverse cardiac events (p=0.026), first cardiovascular hospitalization and repeat cardiac testing (p=0.0011) compared to those with normal GLS. Abnormal GLS appears to be a better predictor than abnormal WMSI in predicting major adverse cardiac events (p=0.174) and time to first cardiovascular hospitalization or repeat cardiac testing (p=0.0093). Conclusion: GLS may be a better predictor of long-term major adverse cardiac events, readmissions and repeat cardiac testing than WMSI in patients undergoing stress echocardiography.
Outcome and Management of Refractory Respiratory Failure With Timely Extracorporeal Membrane Oxygenation: Single-Center Experience With Legionella Pneumonia
Authors: Roncon-Albuquerque Roberto , Vilares-Morgado Rodrigo , van der Heijden Gert-Jan , Ferreira-Coimbra João , Mergulhão Paulo , Paiva José Artur 
Published: March 2017

Objective: To analyze the management and outcome of patients with refractory respiratory failure complicating severe Legionella pneumonia rescued with extracorporeal membrane oxygenation (ECMO) in our Center. Design and Setting: Observational study of patients with refractory respiratory failure treated with ECMO in Hospital S.João (Porto, Portugal), between November 2009 and September 2016. Participants: A total of 112 patients rescued with ECMO, of which 14 had Legionella pneumonia. Results: Patients with Legionella pneumonia were slightly older than patients with acute respiratory failure of other etiologies (51 [48-56] vs 45 [35-54]), but with no significant differences in acute respiratory failure severity between groups: Pao2/Fio2 ratio 67 (60-75) versus 69 (55-85) and Respiratory Extracorporeal Membrane Oxygenation Survival Prediction score 4 (1-5) versus 2 (-1-4), respectively. Legionella pneumonia was associated with earlier ECMO initiation (days of invasive mechanical ventilation [IMV] before ECMO: 2.0 [1.0-4.0] vs 5.0 [2.0-9.5]). After IMV adjustment to “lung rest” settings, this group presented higher respiratory system (RS) static compliance (28.7 [18.8-37.4] vs 16.0 [10.0-20.8] mL/cmH2O) but required higher ECMO support (blood flow 5.0 [4.3-5.4] vs 4.2 [3.6-4.8]). Patients with Legionella pneumonia had shorter IMV (16 [14-23] vs 27 [20-42] days) and lower incidence of intensive care unit nosocomial infections (35.7% vs 64.3%), with a trend to higher hospital survival (85.7% vs 62.2%; P = .13). Conclusion: In Legionella pneumonia complicated by refractory respiratory failure, ECMO support allowed patient stabilization under lung protective ventilation and high survival rates. Timely ECMO referral should be considered for Legionella pneumonia failing conventional treatment.
The effects of dual-therapy intensification with insulin or dipeptidylpeptidase-4 inhibitor on cardiovascular events and all-cause mortality in patients with type 2 diabetes: A retrospective cohort study
Authors: Jil Mamza , Rajnikant Mehta , Richard Donnelly , Iskandar Idris 
Published: March 2017

Purpose:To compare time to a composite endpoint of non-fatal acute myocardial infarction, non-fatal stroke or all-cause mortality in patients with type 2 diabetes mellitus who had their treatment intensified with a dipeptidylpeptidase-4 inhibitor or insulin following dual-therapy (metformin plus sulfonylurea) failure.Methods:A retrospective cohort study was conducted on 5238 patients newly treated with either a dipeptidylpeptidase-4 inhibitor or insulin following dual-therapy failure (2007–2014). Data were sourced from UK General Practices. The risk of the composite outcome was compared between two treatment groups: metformin + sulfonylurea + insulin ( n = 1584) and metformin + sulfonylurea + dipeptidylpeptidase-4 inhibitor ( n = 3654), while adjusting for baseline covariates. Follow-up was for up to 5 years. Propensity score matching analysis and Cox proportional hazard models were employed.Results:Overall, 123 and 171 composite outcome events occurred among patients who added insulin versus dipeptidylpeptidase-4 inhibitor, respectively (44.5 vs 14.6 events per 1000 person-years). Addition of insulin was associated with a significantly higher hazard ratio versus the addition of a dipeptidylpeptidase-4 inhibitor (adjusted hazard ratio = 2.6, 95% confidence interval: 1.9–3.4; p < 0.01), an effect that was more pronounced in obese (body mass index: 30–34.9 kg/m2) patients (corresponding adjusted hazard ratio 3.6, 95% confidence interval: 2.3–5.6; p < 0.01).Conclusion:In routine clinical practice, intensification of metformin + sulfonylurea therapy by adding insulin is associated with increased risk of cardiovascular events and death compared with adding a dipeptidylpeptidase-4 inhibitor. These findings are in line with suggestions from previous studies regarding the cardiovascular safety of insulin in type 2 diabetes mellitus, but should be interpreted with caution.
Living Independently: Exploring the Experiences of Visually Impaired People Living in Age-Related and Lifetime Housing Through Qualitative Synthesis
Authors: Rooney Clíona , Hadjri Karim , Faith Verity , Rooney Máirin , McAllister Keith , Craig Cathy 
Published: March 2017

Objectives: The aim of this study is to gain a deeper understanding of the experiences of visually impaired older people living independently at home. Background: As populations are aging globally, there is now an increase in the prevalence of visual impairment. That means for ongoing and future aging-in-place strategies that seek to enable older people to remain independent for longer, more attention needs to be given to the needs of those with visual impairment. As people develop visual impairment, they use adaptive strategies including modifying long-term homes or relocating to more suitable accommodation. In the United Kingdom, aging-in-place strategies include employing statutory lifetime home standards (LTHS) in the home or relocating to sheltered housing to live independently with support available if required. Methods: To get a better understanding of the needs of the visually impaired in the home, 12 interviews with six visually impaired occupants of LTHS homes and six from sheltered accommodation were analyzed separately using interpretative phenomenological analysis. Secondly, qualitative synthesis was used to further analyze themes generated from both samples before interview results were conceptualized in two superordinate concepts, namely, “negotiating priorities” and “understanding visual impairment.” Results: Participants from both groups had similar needs and were willing to compromise by living with some negative features. Those who coped well with moving utilized various resources. Conclusions: These findings will shed more understanding on providing good quality housing for those with visual impairment wanting to live either independently or within healthcare home environments.
An updated systematic review and meta-analysis for treatment of multidrug-resistant tuberculosis
Authors: Bastos Mayara Lisboa , Lan Zhiyi , Menzies Dick 
Published: March 2017

This systematic review aimed to update the current evidence for multidrug-resistant tuberculosis (MDR-TB) treatment.We searched for studies that reported treatment information and clinical characteristics for at least 25 patients with microbiologically confirmed pulmonary MDR-TB and either end of treatment outcomes, 6-month culture conversion or severe adverse events (SAEs). We assessed the association of these outcomes with patients' characteristics or treatment parameters. We identified 74 studies, including 17 494 participants.The pooled treatment success was 26% in extensively drug-resistant TB (XDR-TB) patients and 60% in MDR-TB patients. Treatment parameters such as number or duration and individual drugs were not associated with improved 6-month sputum culture conversion or end of treatment outcomes. However, MDR-TB patients that received individualised regimens had higher success than patients who received standardised regimens (64%versus52%; p<0.0.01). When reports from 20 cohorts were pooled, proportions of SAE ranged from 0.5% attributed to ethambutol to 12.2% attributed to para-aminosalicylic acid. The lack of significant associations of treatment outcomes with specific drugs or regimens may reflect the limitations of pooling the data rather than a true lack of differences in efficacy of regimens or individual drugs.This analysis highlights the need for stronger evidence for treatment of MDR-TB from better-designed and reported studies.
Effectiveness and safety of clofazimine in multidrug-resistant tuberculosis: a nationwide report from Brazil
Authors: Dalcolmo Margareth , Gayoso Regina , Sotgiu Giovanni , D'Ambrosio Lia , Rocha Jorge L. , Borga Liamar , Fandinho Fatima , Braga Jose U. , Galesi Vera M.N. , Barreira Draurio , Sanchez Denise A. , Dockhorn Fernanda , Centis Rosella , Caminero Jose A. , Migliori Giovanni B. 
Published: March 2017

Although clofazimine is used to treat multidrug-resistant tuberculosis (MDR-TB), there is scant information on its effectiveness and safety. The aim of this retrospective, observational study was to evaluate these factors as well as the tolerability of clofazimine in populations in Brazil, where it was administered at a daily dose of 100 mg·day−1(body weight ≥45 kg) as part of a standardised MDR-TB treatment regimen until 2006 (thereafter pyrazinamide was used).All MDR-TB patients included in the Sistema de Informação de Tratamentos Especiais da Tuberculose (SITETB) individual electronic register were analysed. The effectiveness of clofazimine was assessed by comparing the treatment outcomes of patients undergoing clofazimine-containing regimens against those undergoing clofazimine-free regimens and its safety by describing clofazimine-attributed adverse events. A total of 1446 patients were treated with clofazimine-containing regimens and 1096 with pyrazinamide-containing regimens.Although success rates were similar in patients treated with clofazimineversusthose treated with pyrazinamide (880 out of 1446, 60.9%,versus708 out of 1096, 64.6%; p=0.054), clofazimine-treated cases exhibited higher death rates due to tuberculosis than pyrazinamide-treated ones (314 out of 1446, 21.7%,versus120 out of 1096, 10.9%) but fewer failures (78 out of 1446, 5.4%,versus95 out of 1096, 8.7%) and less loss to follow-up (144 out of 1446, 10.0%,versus151 out of 1096, 13.8%). No relevant differences were detected when comparing adverse events in patients treated with clofazimine-containing regimens to those treated with clofazimine-free regimens. However, the incidence of side-effects was less than previously reported (gastro-intestinal complaints: 10.5%; hyper-pigmentation: 50.2%; neurological disturbances: 9–13%).
MMP-7 is a predictive biomarker of disease progression in patients with idiopathic pulmonary fibrosis
Authors: Bauer Yasmina , White Eric S. , de Bernard Simon , Cornelisse Peter , Leconte Isabelle , Morganti Adele , Roux Sebastien , Nayler Oliver 
Published: March 2017

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with poor prognosis, which is characterised by destruction of normal lung architecture and excessive deposition of lung extracellular matrix. The heterogeneity of disease progression in patients with IPF poses significant obstacles to patient care and prevents efficient development of novel therapeutic interventions. Blood biomarkers, reflecting pathobiological processes in the lung, could provide objective evidence of the underlying disease.Longitudinally collected serum samples from the Bosentan Use in Interstitial Lung Disease (BUILD)-3 trial were used to measure four biomarkers (metalloproteinase-7 (MMP-7), Fas death receptor ligand, osteopontin and procollagen type I C-peptide), to assess their potential prognostic capabilities and to follow changes during disease progression in patients with IPF.In baseline BUILD-3 samples, only MMP-7 showed clearly elevated protein levels compared with samples from healthy controls, and further investigations demonstrated that MMP-7 levels also increased over time. Baseline levels of MMP-7 were able to predict patients who had higher risk of worsening and, notably, baseline levels of MMP-7 could predict changes in FVC as early as month 4.MMP-7 shows potential to be a reliable predictor of lung function decline and disease progression.
Effects of bile acids on human airway epithelial cells: implications for aerodigestive diseases
Authors: Aldhahrani Adil , Verdon Bernard , Ward Chris , Pearson Jeffery 
Published: March 2017

Gastro-oesophageal reflux and aspiration have been associated with chronic and end-stage lung disease and with allograft injury following lung transplantation. This raises the possibility that bile acids may cause lung injury by damaging airway epithelium. The aim of this study was to investigate the effect of bile acid challenge using the immortalised human bronchial epithelial cell line (BEAS-2B).The immortalised human bronchial epithelial cell line (BEAS-2B) was cultured. A 48-h challenge evaluated the effect of individual primary and secondary bile acids. Post-challenge concentrations of interleukin (IL)-8, IL-6 and granulocyte−macrophage colony-stimulating factor were measured using commercial ELISA kits. The viability of the BEAS-2B cells was measured using CellTiter-Blue and MTT assays.Lithocholic acid, deoxycholic acid, chenodeoxycholic acid and cholic acid were successfully used to stimulate cultured BEAS-2B cells at different concentrations. A concentration of lithocholic acid above 10 μmol·L−1causes cell death, whereas deoxycholic acid, chenodeoxycholic acid and cholic acid above 30 μmol·L−1was required for cell death. Challenge with bile acids at physiological levels also led to a significant increase in the release of IL-8 and IL6 from BEAS-2B.Aspiration of bile acids could potentially cause cell damage, cell death and inflammationin vivo. This is relevant to an integrated gastrointestinal and lung physiological paradigm of chronic lung disease, where reflux and aspiration are described in both chronic lung diseases and allograft injury.