bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant–Microbe Interactions and Secondary Metabolites with Antibacterial, Antifungal and Antiviral Properties
Authors: Reichling Jürgen 
Published: April 2017

AbstractPlants have developed effective defence strategies to protect themselves from phytopathogenic microbes and herbivores in their environment. Disease resistance in plants depends on the activation of coordinated, multicomponent defence mechanisms. One mechanism for disease resistance in plants is their ability to accumulate low‐molecular‐weight compounds (secondary metabolites) with high antimicrobial activities, such as alkaloids, coumarins, isoflavonoids, polyacetylenes, quinones, tannins and terpenes.Based on this knowledge, there is every reason to believe that the plant kingdom is an important source of new antimicrobial agents with special biological targets. Thus, in the last two decades, hundreds of different new secondary metabolites were screened for their potential antibacterial, antifungal and antiviral activities. For instance, several secondary metabolites with antiviral properties have exhibited competitive in vitro and in vivo activities with those found for synthetic antiviral drugs. It has been shown that phyto‐antiviral agents interfere with many viral targets, ranging from adsorption of the virus to the host cell via the inhibition of virus‐specific enzymes (e.g. reverse transcriptase, protease) to release virus from the cells.It is generally accepted that bioactive plant‐derived secondary metabolites are useful leads to synthesize new and more active antimicrobial agents as well as substances with new pharmacological effects by repeated structural modification. It is expected that structurally modified natural products will exhibit increased potency, selectivity, duration of action, bioavailability and reduced toxicity.
Stability analysis of quantized iterative learning control systems using lifting representation
Authors: Bu Xuhui , Hou Zhongsheng , Cui Lizhi , Yang Junqi 
Published: April 2017

SummaryThis paper presents a stability analysis of the iterative learning control for discrete‐time systems with data quantization. Three quantized iterative learning control schemes are considered by using different quantized signals, including system output quantized signal, tracking error quantized signal, and control input quantized signal. The logarithmic quantizer is introduced to decode these signals with a number of quantization levels, and the sector bound method is used to deal with the quantization error. Based on the supervector formulation for iterative learning control systems, some convergence conditions for these iterative learning control laws are given, respectively. It is shown that iterative learning control laws with system output quantized signal and control input quantized signal only guarantee that the tracking error converges to a bound and the bound depending on quantization density and desired trajectory. Thus, the iterative learning control law with tracking error quantized signal can obtain zero tracking error. These results are illustrated by 2 examples.
Recent Catalytic Asymmetric Syntheses of 3,3‐Disubstituted Indolin‐2‐ones and 2,2‐Disubstituted Indolin‐3‐ones
Authors: Dalpozzo Renato 
Published: April 2017

AbstractDisubstituted oxindoles represent an important family of bioactive compounds and synthetic derivatives that mimic natural products. The construction of the asymmetric quaternary carbon at C‐3 or C‐2 is therefore a challenging problem for organic chemists. In the last years, many papers have appeared on asymmetric catalytic methods for the synthesis of these compounds, in particular about spirocyclic derivatives and this literature has been largely reviewed, as well as the literature on 3‐substituted‐3‐hydroxyoxindoles and 3‐substituted‐3‐aminooxindoles. On the other hand, the literature on non‐spirocyclic 3,3‐dialkyloxindoles as well as on 2,2‐disubstituted 3‐indolinones has not fully reviewed since our previous review on this topic. This review aims to fill this gap covering the literature on these topics.Abbreviations: Alloc=allyloxycarbonyl; Ant=anthracenyl; BINOL=1,1′‐binaphthalene‐2,2′‐diol; Boc=t‐butoxycarbonyl; Bz=benzoyl; Cbz=benzyloxycarbonyl; CSA=camphorsulfonic acid; Cy=cyclohexyl; DABCO=1,4‐diazabicyclo[2.2.2]octane; dba=bis(dibenzylideneacetone); DBU=1,8‐diazabicyclo[5.4.0]undec‐7‐ene; DDQ=2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone; (DHQD)2AQN=hydroquinidine (anthraquinone‐1,4‐diyl) diether; (DHQD)2PHAL=hydroquinidine 1,4‐phthalazinediyl diether; (DHQD)2PYR=hydroquinidine 2,5‐diphenyl‐4,6‐pyrimidinediyl diether; DIPEA=N,N‐diisopropylethylamine; esp=α,α,α′,α′‐tetramethyl‐1,3‐benzenedipropionic acid; HFIP=1,1,1,3,3,3‐hexafluoro‐2‐propanol; HMDS=hexamethyldisilazane; β‐ICD=β‐isocupreidine; LG=leaving group; Mes=2,4,6‐trimethylphenyl; Moc=methoxycarbonyl; MOM=methoxymethyl; MS=molecular sieves; MsOH=methanesulfonic acid; NHC=N‐heterocyclic carbene; Npt=naphthyl; PG=protecting group; Phg=phenylglycine; Phth=phthalimidyl; Piv=2,2‐dimethylpropanoyl; PMB=4‐methoxybenzyl; Red‐Al=sodium bis(2‐methoxyethoxy)aluminium hydride; Suc=succinimidyl; TBDPS=tert‐butyldiphenylsilyl; TBS=tert‐butyldimethylsilyl; TES=triethylsilyl; TIPS=triisopropylsilyl; TMEDA=N,N,N′,N′‐tetramethylethylenediamine; TMG=1,1,3,3‐tetramethylguanidine; TMS=trimethylsilyl; Ts=4‐toluenesulfonyl.magnified image
Cyclodextrin‐based Mesoporous N‐Doped Carbon Hybrids with High Heterocatalytic Activity
Authors: Tian Jun , Chen Yong , Li Wei , Liu Yu‐Ping , Zhou Wei‐Lei , Liu Yu 
Published: April 2017

AbstractA convenient approach for the construction of nitrogen‐doped mesoporous carbon material from native cyclic oligosaccharide β‐cyclodextrin and N‐containing small molecules was established. The resultant N‐doped carbon hybrids, which possessed high Brunauer–Emmett–Teller (BET) surface area as well as appropriate pore volumes and pore diameters, could serve as highly efficient metal‐free heterocatalysts with very good catalytic activity as well as generality and could be easily recovered without any compromise of catalytic performance.
Highly Enantioselective Friedel–Crafts Reactions of Indoles with Isatins Catalyzed by Chiral Imidodiphosphoric Acids
Authors: Liu Guofeng , Zhuo Minghua , An Dong , Zhang Guangliang , Qin Xiangshuo , Gao Jigang , Fan Yansen , Zhang Suoqin 
Published: April 2017

AbstractA highly enantioselective Friedel–Crafts arylation of indoles with isatins catalyzed by H8‐1,1’‐bi‐2‐naphthol (BINOL) imidodiphosphoric acids is reported here. This reaction proceeds smoothly under mild conditions and afford a range of 3‐hydroxy‐3‐indolyloxindoles with high yields (<92 %) and excellent enantioselectivities (<99 % ee). To the best of our knowledge, this is the first example in which the highly enantioselective arylation of indoles with isatins has been catalyzed by a Brønsted acid.
Quality of life after mastectomy with or without immediate breast reconstruction
Authors: Dauplat J , Kwiatkowski F , Rouanet P , Delay E , Clough K , Verhaeghe J L , Raoust I , Houvenaeghel G , Lemasurier P , Thivat E , Pomel C ,   STIC-RMI working group, Abrial C , Afonso J , Bannier M , Body G , Baron M , Bergzoll C , Chauvet M P , Classe J M , Cothier-Savey I , Dejode M , Dessogne P , Doridot V , Durando X , Faucher A , Faure C , Figl A , Fitoussi A , Flipo B , Fondrinier E , Garbay J R , Giacalone P L , Gimbergue P , Guillemin F , Gutowski M , Houpeau J L , Inguenault C , Lambaudie E , Lantieri L , Le Bouedec G , Lepage C , Loustalot C , Machiavello J C , Monrigal E , Mourregot A , Nos C , Paradol P O , Rimareix F , Rodier J F , Rouzier R , Saint-Aubert B , Salmon R J , Scherer C , Toussoun G , Tunon de Lara C , Uzan S , Weitbruch D 
Published: April 2017

Abstract

Background
Mastectomy with immediate breast reconstruction (IBR) is a surgical strategy in breast cancer when breast-conserving surgery is not an option. There is a lack of evidence showing an advantage of mastectomy plus IBR over mastectomy alone on health-related quality of life (QoL).

Methods
A large prospective multicentre survey, STIC-RMI (support of innovative and expensive techniques – immediate breast reconstruction), was undertaken to study the changes in QoL in patients treated by mastectomy with or without IBR. Patients were recruited between 2007 and 2009. European Organisation for Research and Treatment of Cancer QLQ-C30 and QLQ-BR23 instruments were used to assess QoL before operation, and at 6 and 12 months after surgery. A propensity score was used to compare QoL between mastectomy alone and mastectomy plus IBR, with limited bias.

Results
A total of 595 patients were included from 22 French academic hospitals, of whom 407 (68·4 per cent) underwent IBR. One-year data were available for 71·1 per cent of patients. Factors associated with IBR were age, histological tumour type, palpable nodes and an attempt at breast-conserving surgery. At inclusion, QoL was significantly better in the IBR group (P &lt; 0·001) and there was no significant change in either group during 1 year compared with baseline. Results for the QLQ-BR23 functional dimension varied according to propensity score quartiles; IBR had no influence in the lowest quartile. In the upper quartiles, QoL increased slightly over the year among patients who had IBR, whereas it decreased among those who had mastectomy alone (P = 0·037). Satisfaction with the cosmetic outcome strongly influenced QoL, especially in upper quartiles (P &lt; 0·001). However, an unsatisfactory outcome after IBR was still considered a better condition than simple mastectomy.

Conclusion
The QoL benefit provided by IBR depends on patients' life status at inclusion; young active women with an in situ tumour are more likely to preserve their QoL after IBR.
Targeting resolution of neuroinflammation after ischemic stroke with a lipoxin A4 analog: Protective mechanisms and long‐term effects on neurological recovery
Authors: Hawkins Kimberly E. , DeMars Kelly M. , Alexander Jon C. , de Leon Lauren G. , Pacheco Sean C. , Graves Christina , Yang Changjun , McCrea Austin O. , Frankowski Jan C. , Garrett Timothy J. , Febo Marcelo , Candelario‐Jalil Eduardo 
Published: April 2017

AbstractBackgroundResolution of inflammation is an emerging new strategy to reduce damage following ischemic stroke. Lipoxin A4 (LXA4) is an anti‐inflammatory, pro‐resolution lipid mediator that reduces neuroinflammation in stroke. Since LXA4 is rapidly inactivated, potent analogs have been synthesized, including BML‐111. We hypothesized that post‐ischemic, intravenous treatment with BML‐111 for 1 week would provide neuroprotection and reduce neurobehavioral deficits at 4 weeks after ischemic stroke in rats. Additionally, we investigated the potential protective mechanisms of BML‐111 on the post‐stroke molecular and cellular profile.MethodsA total of 133 male Sprague‐Dawley rats were subjected to 90 min of transient middle cerebral artery occlusion (MCAO) and BML‐111 administration was started at the time of reperfusion. Two methods of week‐long BML‐111 intravenous administration were tested: continuous infusion via ALZET® osmotic pumps (1.25 and 3.75 μg μl−1 hr−1), or freshly prepared daily single injections (0.3, 1, and 3 mg/kg). We report for the first time on the stability of BML‐111 and characterized an optimal dose and a dosing schedule for the administration of BML‐111.ResultsOne week of BML‐111 intravenous injections did not reduce infarct size or improve behavioral deficits 4 weeks after ischemic stroke. However, post‐ischemic treatment with BML‐111 did elicit early protective effects as demonstrated by a significant reduction in infarct volume and improved sensorimotor function at 1 week after stroke. This protection was associated with reduced pro‐inflammatory cytokine and chemokine levels, decreased M1 CD40+ macrophages, and increased alternatively activated, anti‐inflammatory M2 microglia/macrophage cell populations in the post‐ischemic brain.ConclusionThese data suggest that targeting the endogenous LXA4 pathway could be a promising therapeutic strategy for the treatment of ischemic stroke. More work is necessary to determine whether a different dosing regimen or more stable LXA4 analogs could confer long‐term protection.
Temozolomide increases MHC‐I expression via NF‐κB signaling in glioma stem cells
Authors: Zhang Dongyong , Qiu Bo , Wang Yunjie , Guan Yanlei , Zhang Luyang , Wu Anhua 
Published: April 2017

AbstractGliomas are the most common and primary tumors of the central nervous system in adults. Temozolomide (TMZ) is the main drug used to treat glioma; however, prognosis remains poor for most patients. Glioma stem cells (GSCs) are thought to enable glioma initiation and evasion from immune surveillance; their immunogenicity can be determined by expression of major histocompatibility complex (MHC)‐I. The present study investigated the effect of TMZ on MHC‐I expression in GSCs. Glioma spheres were cultured in serum‐free medium containing epidermal growth factor, basic fibroblast growth factor, and B27; MHC‐I expression was detected by immunocytochemistry, quantitative real‐time PCR, and flow cytometry. Nuclear factor (NF)‐κB expression in glioma stem cells was detected by Western blot. TMZ enhanced MHC‐I expression in GSCs, and NF‐κB was activated. TMZ treatment increased MHC‐I expression via modulation of NF‐κB signaling in GSCs. In addition to being a chemotherapeutic agent, TMZ may also serve as an immunomodulatory agent in the treatment of glioma patients.
Human mesenchymal stem cells promote CD34+ hematopoietic stem cell proliferation with preserved red blood cell differentiation capacity
Authors: Lau Show Xuan , Leong Yin Yee , Ng Wai Hoe , Ng Albert Wee Po , Ismail Ida Shazrina , Yusoff Narazah Mohd , Ramasamy Rajesh , Tan Jun Jie 
Published: April 2017

AbstractStudies showed that co‐transplantation of mesenchymal stem cells (MSCs) and cord blood‐derived CD34+ hematopoietic stem cells (HSCs) offered greater therapeutic effects but little is known regarding the effects of human Wharton's jelly derived MSCs on HSC expansion and red blood cell (RBC) generation in vitro. This study aimed to investigate the effects of MSCs on HSC expansion and differentiation. HSCs were co‐cultured with MSCs or with 10% MSCs‐derived conditioned medium, with HSCs cultured under standard medium served as a control. Cell expansion rates, number of mononuclear cell post‐expansion and number of enucleated cells post‐differentiation were evaluated. HSCs showed superior proliferation in the presence of MSC with mean expansion rate of 3.5 × 108 ± 1.8 × 107 after day 7 compared to the conditioned medium and the control group (8.9 × 107 ± 1.1 × 108 and 7.0 × 107 ± 3.3 × 106 respectively, P < 0.001). Although no significant differences in RBC differentiation were observed between groups at passage IV, the number of enucleated cell was greater compared to earlier passages, indicating successful RBC differentiation. Cord blood‐derived CD34+ HSCs can be greatly expanded by co‐culturing with MSCs without affecting the RBC differentiation capability, suggesting the importance of direct MSC‐HSCs contact in HSC expansion and RBC differentiation.
Mental health and associated factors among young offenders in Chile: a cross‐sectional study
Authors: Gaete Jorge , Labbé Nicolas , del Villar Paloma , Allende Catalina , Araya Ricardo , Valenzuela Eduardo 
Published: April 2017

AbstractBackgroundFew studies in Latin America have explored mental disorder among young offenders, or variables associated with it.AimsOur aim was to test for associations between childhood adversity or substance misuse and psychiatric disorders among young offenders.MethodsSentenced adolescent offenders were recruited from young offenders' institutions or community centres provided by the Chilean National Service for Minors. Psychiatric disorders were assessed using the Mini International Neuropsychiatric Interview, conducted by trained psychologists. A trained sociologist used an ad hoc interview to collect information about childhood experiences, including parenting, trauma, education and substance misuse. Multivariable logistic regressions were used to analyse data.ResultsThe most prevalent psychiatric disorders among the 935 participants were marijuana dependence disorder, major depressive disorder, and anxiety disorders. Substance use disorders were less frequent among young offenders who were serving their sentence in young offenders' institutions than among those serving in community centres and more frequent among those who started to use marijuana at an earlier age. Among other variables, childhood maltreatment was related to major depressive disorder, and maternal death to anxiety disorders. Higher educational status was related to a lower frequency of depressive and anxiety disorders.ConclusionsOur findings suggest that greater efforts must be made to identify vulnerable young people much earlier. Few of these young offenders with mental health problems had been well adjusted in health, education or socially before this period of detention. © 2017 The Authors. Criminal Behaviour and Mental Health Published by John Wiley & Sons Ltd
A Unified Interdisciplinary Approach to Design Antibacterial Coatings for Fast Silver Release
Authors: El Arrassi A. , Bellova P. , Javid S. M. , Motemani Y. , Khare C. , Sengstock C. , Köller M. , Ludwig A. , Tschulik K. 
Published: April 2017

AbstractThe increasing number of surgical treatments performed per year requires novel approaches to inhibit implant‐associated infections, caused by multi‐antibiotic resistant bacteria. Silver ions (Ag+) are known for their effective antimicrobial activity. Therefore, a system that efficiently and locally releases the minimum required amount of Ag+ directly after the surgical treatment is in high demand. Herein we study electrochemically, microbiologically, microscopically and spectroscopically sacrificial Ag anode coatings for antibacterial implant applications. It is found that Ag dot arrays deposited on noble metals (Pd, Ir) release Ag+ much faster than continuous Ag thin films. The Ag+ release qualitatively scales with the difference of standard potentials between Ag and the noble metal. Furthermore, with higher numbers of Ag dots, the total amount of released Ag+ increases, while the release efficiency declines. Notably, an efficient killing of Staphylococcus aureus bacteria was seen for coatings containing as little as 23 ng of Ag per mm2. Thus, the use of sacrificial Ag anodes as highly efficient antibacterial coating materials is evaluated.
Redox‐Neutral Dual Functionalization of Electron‐Deficient Alkenes
Authors: Pettersson Fredrik , Bergonzini Giulia , Cassani Carlo , Wallentin Carl‐Johan 
Published: April 2017

AbstractVisible‐light photoredox catalysis has been utilized in a new multicomponent reaction forming β‐functionalized δ‐diketones under mild conditions in an operationally convenient manner. Single‐electron reduction of in situ generated carboxylic acid derivatives forms acyl radicals that react further via 1,2‐acylalkylation of olefins in an intermolecular, three‐components cascade reaction, giving valuable synthetic entities from readily available starting materials. A diverse set of substrates has been used, demonstrating robust methodology with broad substrate scope.
Preparative chiral separation and absolute configuration of the synthetic pterocarpanquinone LQB‐118
Authors: Scatena Gabriel S. , Cassiano Neila M. , Netto Chaquip D. , Costa Paulo R.R. , Cass Quezia B. , Batista João M. 
Published: April 2017

AbstractThe racemic pterocarpanquinone LQB‐118 is active, in mice and hamsters, against tegumentary and visceral leishmaniasis. This compound also presents antiinflammatory and antineoplastic activity in mice. The low level of toxicity observed in these studies makes LQB‐118 a promising drug candidate. In order to conduct further biological testing to investigate enantioselectivity in the above‐mentioned activities, a multimilligram amount of each enantiomer of LQB‐118 was produced. Furthermore, vibrational circular dichroism (VCD) and Density Functional Theory (DFT) calculations were used to determine unambiguously their absolute configurations. The comparison of experimental and calculated VCD data led to the assignment of (−)‐LQB‐118 as 7aR,12aR and, consequently, (+)‐LQB‐118 as 7aS12aS.
Königsblau statt krebserregend
Authors: Bertsche Ingo 
Published: April 2017

AbstractIn diesem Beitrag wird das Königsblau‐Reagenz als neues, ungefährliches und zuverlässiges Nachweisreagenz für Aldehyde vorgestellt. Mit Königsblau‐Reagenz lassen sich flüchtige Aldehyde mit hoher Empfindlichkeit in der Gasphase nachweisen. Die Wirksamkeit wird eindrucksvoll an klassischen Experimenten demonstriert.
An Integrin‐Targeting RGDK‐Tagged Nanocarrier: Anticancer Efficacy of Loaded Curcumin
Authors: Das Krishnendu , Nimushakavi Sahithi , Chaudhuri Arabinda , Das Prasanta Kumar 
Published: April 2017

AbstractHerein we report the design and development of α5β1 integrin‐specific noncovalent RGDK–lipopeptide‐functionalized single‐walled carbon nanotubes (SWNTs) that selectively deliver the anticancer drug curcumin to tumor cells. RGDK tetrapeptide‐tagged amphiphiles were synthesized that efficiently disperse SWNTs with a suspension stability index of >80 % in cell culture media. 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT)‐ and lactate dehydrogenase (LDH)‐based cell viability assays in tumor (B16F10 melanoma) and noncancerous (NIH3T3 mouse fibroblast) cells revealed the non‐cytotoxic nature of these RGDK–lipopeptide–SWNT conjugates. Cellular uptake experiments with monoclonal antibodies against αvβ3, αvβ5, and α5β1 integrins showed that these SWNT nanovectors deliver their cargo (Cy3‐labeled oligonucleotides, Cy3‐oligo) to B16F10 cells selectively via α5β1 integrin. Notably, the nanovectors failed to deliver the Cy3‐oligo to NIH3T3 cells. The RGDK–SWNT is capable of delivering the anticancer drug curcumin to B16F10 cells more efficiently than NIH3T3 cells, leading to selective killing of B16F10 cells. Results of Annexin V binding based flow cytometry experiments are consistent with selective killing of tumor cells through the late apoptotic pathway. Biodistribution studies in melanoma (B16F10)‐bearing C57BL/6J mice showed tumor‐selective accumulation of curcumin intravenously administered via RGDK–lipopeptide–SWNT nanovectors.