bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor-faktor yang Berpengaruh pada Struktur Modal dan Kaitan dengan Teori Pecking Order & Trade-off: Systematic Literature Review
Authors: Martono Adi , Ramdani Edon 
Published: September 2024

Penelitian mengenai struktur modal Perusahaan telah banyak dilakukan oleh para peneliti. Peneliti menguji beberapa teori dalam penelitiannya seperti teori-teori Pecking Order, Trade-off Theory, Market Timing dan Agency serta menguji faktor-faktor yang mempengaruhi struktur modal baik dari internal dan eksternal Perusahaan. Penelitian ini bertujuan untuk mengetahui faktor-faktor struktur modal internal maupun eksternal perusahaan yang banyak diteliti serta melihat faktor-faktor apa saja yang berpengaruh secara signifikan di setiap faktor internal maupun eksternal perusahaan tersebut. Penelitian ini menggunakan data bersumber dari penelitian selama 5 tahun. Metodologi penelitian yang dipakai dalam penelitian ini adalah Systematic Literature Review. Dengan menggunakan protokol PRISMA diperoleh 30 artikel yang relevan, dari total data jurnal yang terindeks Scopus sebanyak 1.081 artikel, yang diterbitkan dalam periode tahun 2019 hingga 2024. Data yang berhasil dihimpun berasal dari jurnal nasional dan internasional. Hasil penelitian diperoleh bahwa faktor-faktor internal perusahaan yang diteliti, seperti non debt tax shield, struktur kepemiikan perusahaan, earning volatility berpengaruh signifikan terhadap struktur modal perusahaan dan hal ini sejalan dengan teori Pecking Order yang mengasumsikan bahwa untuk menghasilkan laba perusahaan menggunakan dana dari internal perusahaan dan penggunaan utang dilakukan saat sumber-sumber pendanaa internal tidak mencukupi. Sedangkan faktor eksternal Perpajakan merupakan faktor yang berpengaruh signifikan terhadap struktur modal dan hal ini sejalan dengan teori Trade-off.
Haemodynamic Responses Following Lidocaine Infusion on Hypertensive Patient Undergoing Laparoscopic Cholecystectomy
Authors: Rahman Md Akkasur , Mahabubuzzaman Mohammad , Saddam Abdullah Mohammad , Bhowmick Lipon Kanti , Kabir Humaiun , Rahim Md Abdur 
Published: September 2024

Many pharmacological methods have been evaluated to attenuate the adverse haemodynamic responses resulting from airway manipulation and pneumoperitoneum. Intravenous lidocaine infusion is one of them; bolus dose of intravenous lidocaine is used to reduce haemodynamic changes resulting from intubation and extubation reflex whereas intraoperative infusion of lidocaine has been used for post-operative analgesia in laparoscopic cholecystectomy. This randomized controlled trial was conducted to observe the effectiveness of lidocaine infusion in obtundation of haemodynamic responses on hypertensive patient undergoing laparoscopic cholecystectomy. A total number of 80 patients were enrolled in this study. Patients were allocated into two groups by computer generated random chart according to a 1:1 ratio. The patients of group A were given general anaesthesia with placebo normal saline infusion and the patients of group B were given general anaesthesia with lidocaine infusion (1.5mg/kg). Mean differences of blood pressure (SBP & MAP) and heart rate at different time periods from baseline were compared between two groups. The demographic profiles were almost similar between the groups (p>0.05). In comparison between two groups, heart rate, systolic blood pressure and mean arterial pressure rise from baseline value was more in normal saline group (group A) than lidocaine test group (group B) during peri-intubation, pneumoperitoneum and peri-extubation period. Statistical difference was significant between two groups (p<0.05) in different haemodynamic parameters. Adverse events such as tachycardia premature ventricular contraction (PVC) and hypertension were observed much more in group A, which was higher than that of group B. We observed that administration of lidocaine infusion attenuates haemodynamic responses of hypertensive patient during laparoscopic cholecystectomy.
CBMJ 2024 July: vol. 13 no. 02 P: 148-157
Pengaruh Terpaan Pesan Kode Promo GrabFood terhadap Loyalitas Pelanggan pada Mahasiswa Kota Surabaya
Authors: Putri Nadia , Huda Anam Miftakhul 
Published: September 2024

Persaingan bisnis tranportasi berbasis online semakin berkembang di Indonesia sehingga perusahaan harus memperhatikan strategi komunikasi pemasarannya agar tidak kalah bersaing dengan kompetitor. Pentingnya mempertahankan loyalitas pelanggan bagi sebuah perusahaan akan meningkatkan keuntungan 25% hingga 58%. Perusahaan transportasi online Grab yang telah berkembang di Indonesia sejak tahun 2014 menjadi objek yang akan diteliti pada penelitian ini. Grab telah mengembangkan bisnisnya di seluruh wilayah Indonesia hingga saat ini menjadi aplikasi transportasi online kedua yang memiliki pengguna terbanyak setelah Gojek. Penelitian ini dilakukan untuk mengetahui pengaruh pesan kode promo yang dilakukan oleh Grab melalui terpaan medianya terhadap loyalitas pelanggan. Penelitian ini menggunakan penelitian kuantitatif eksplanatif untuk menguji variabel terpaan pesan kode promo dan loyalitas pelanggan. Peneliti menggunakan populasi mahasiswa kota Surabaya sebanyak 272.846 orang dengan teknik pengambilan sampel berupa non probability sampling untuk mengambil data sebanyak 348 responden. Metode yang digunakan adalah survey maka penelitian dilakukan dengan menyebarkan kuesioner online berupa Google Form yang diukur dengan skala Likert. Pengembangan instrumen dilakukan uji validitas dan uji reliabilitas dengan 30 responden untuk menguji kelayakan instrumen untuk penelitian. Dalam menganalisis data penelitian untuk menguji hipotesis penelitian bahwa terdapat pengaruh positif terpaan pesan kode promo Grab terhadap loyalitas pelanggan maka teknik analisis yang dilakukan adalah uji korelasi Spearman Rank. Ditemukan koefisien korelasinya adalah 0,54 yang termasuk kategori hubungan yang sedang. Hasil penelitian menunjukkan bahwa durasi pelanggan dalam membaca pesan kode promo GrabFood adalah rendah, intensitas pelanggan dalam memahami informasi adalah tinggi, dan frekuensi pelanggan dalam menerima informasi dan membuka aplikasi adalah tinggi. Koefisien korelasi dilakukan pengujian signifikansinya dengan uji t dan uji z menghasilkan pengaruh yang positif dan signifikan. Penelitian ini menghasilkan hipotesis penelitian diterima bahwa terdapat pengaruh positif terpaan pesan kode promo Grab terhadap loyalitas pelanggan. Berdasarkan nilai koefisien determinasi yang ditemukan adalah 0,30 maka disimpulkan bahwa 30% loyalitas pelanggan dipengaruhi oleh terpaan pesan kode promo Grab dan 70% dipengaruhi oleh faktor-faktor lain.
THE COMMODIFICATION OF JOURNALISTS AT RADAR BEKASI NEWSPAPER
Authors: Miftakhudin Miftakhudin 
Published: September 2024

ABSTRAK / ABSTRACT
Penelitian ini berusaha menjelaskan proses komodifikasi pekerja (wartawan) di Koran Radar Bekasi. Dalam penelitian ini, peneliti mengembangkan kerangka pemikiran teori ekonomi politik media yang pintu masuk pertamanya adalah komodifikasi. Hasil penelitian ini menemukan bahwa telah terjadi komodifikasi pekerja terhadap wartawan di Koran Radar Bekasi. Wartawan yang seharusnya mencari, mengumpulkan dan mengolah berita untuk disebarkan ke khalayak, namun di berdayagunakan oleh perusahaan untuk mencari iklan. Transformasi wartawan koran Radar Bekasi yakni melalui Separate, Concentrate, Recontitute. Dalam menjalankan tugasnya, wartawan Koran Radar Bekasi juga berfungsi sebagai fasilitator, penjual koran, pelobi, dan agen iklan.

This research attempts to explain the commodification process of workers (reporters) in Radar Bekasi Newspaper. In this study, researchers developed a framework for the theory of media political economy whose first entrance was commodification. The results of this study found that there had been commodification of workers against journalists at Radar Bekasi Newspaper. Journalists who are supposed to search, collect and process news to be distributed to the public, but are utilized by the company to look for advertisements. Transformation of Radar Bekasi newspaper reporters through Separate, Concentrate, Recontitute. In carrying out its duties, Koran Radar Bekasi journalists also function as facilitators, newspaper sellers, lobbyists, advertising agents and promotional brokers.
Investigation on the mechanisms of carbapenem resistance among the non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae
Authors: Lee Yee Qing , Sri La Sri Ponnampalavanar Sasheela , Wong Jia Haw , Kong Zhi Xian , Ngoi Soo Tein , Karunakaran Rina , Lau Min Yi , Abdul Jabar Kartini , Teh Cindy Shuan Ju 
Published: September 2024

BackgroundIn Malaysia, an increase in non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae (NC-CRKP) has been observed over the years. Previously, four NC-CRKP with increased susceptibility to ciprofloxacin in the presence of phenylalanine-arginine β-naphthylamide (PAβN) were identified. However, no contribution of the PAβN-inhibited efflux pump to carbapenem resistance was observed. All four NC-CRKP harboured non-carbapenemase β-lactamase, with two also exhibiting porin loss. In this study, we further investigated the genomic features and resistance mechanisms of these four isolates.MethodsAll four NC-CRKP were subjected to whole-genome sequencing, followed by comparative genomic and phylogenetic analyses.ResultsMulti-locus sequence typing (MLST) analysis divided the four NC-CRKP into different sequence types: ST392, ST45, ST14, and ST5947. Neither major nor rare carbapenemase genes were detected. Given the presence of non-carbapenemase β-lactamase in all isolates, we further investigated the potential mechanisms of resistance by identifying related chromosomal mutations. Deletion mutation was detected in the cation efflux system protein CusF. Insertion mutation was identified in the nickel/cobalt efflux protein RcnA. Missense mutation of ompK36 porin was detected in two isolates, while the loss of ompK36 porin was observed in another two isolates.ConclusionsThis study revealed that NC-CRKP may confer carbapenem resistance through a combination of non-carbapenemase β-lactamase and potential chromosomal mutations including missense mutation or loss of ompK36 porin and/or a frameshift missense mutation in efflux pump systems, such as cation efflux system protein CusF and nickel/cobalt efflux protein RcnA. Our findings highlighted the significance of implementing whole-genome sequencing into clinical practice to promote the surveillance of carbapenem resistance mechanisms among NC-CRKP.
Precise location of three novel linear epitopes using the generated monoclonal antibodies against the Knob domain of FAdV-4 surface structural protein, fiber1
Authors: Chai Yongxiao , Jin Qianyue , Zhu Rongfang , Guo Zhenhua , Lu Qingxia , Chai Shujun , Xing Yunrui , Han Lu , Xing Guangxu , Zhang Gaiping 
Published: September 2024

BackgroundFowl adenovirus serotype 4 (FAdV-4) is the main pathogen of hepatitis-hydropericardium syndrome (HHS), which brings huge economic losses to the poultry industry worldwide. Fiber-1 protein plays an important role in viral infection and pathogenesis by binding directly to cellular receptors of FAdV-4. In particular, the knob domain of fiber-1 protein has been reported to induce the production of neutralizing antibodies and arouse protection against the lethal challenge of chickens with FAdV-4.MethodsThe fiber-1 knob (F1K) protein was expressed in a prokaryotic expression system and purified using Ni-NTA affinity chromatography. Monoclonal antibodies (mAbs) against FAdV-4 were generated by immunizing BALB/c mice with the purified F1K protein and screened using a series of immunoassays. Potential B cell epitopes on the knob domain of fiber-1 protein were mapped using enzyme-linked immunosorbent assay (ELISA) and dot-blot. Precious location and crucial amino acids of the identified epitopes were determined using peptide array scanning, truncations and alanine-scanning mutagenesis. The epitopes were analyzed and visualized on the knob trimer of FAdV-4 fiber-1 protein using the PyMOL software.ResultsWater-soluble recombinant fiber-1 knob (F1K) protein was obtained with the assistance of chaperone. Four monoclonal antibodies (5C10, 6F8, 8D8, and 8E8) against FAdV-4 were generated and characterized using indirect ELISA, Western blot, dot-blot, and immunological fluorescence assay (IFA). The mAbs were demonstrated to be from different hybridoma cell lines based on the sequences of the variable regions. Meanwhile, three distinct novel linear B-cell epitopes (319SDVGYLGLPPH329, 328PHTRDNWYV336, and 407VTTGPIPFSYQ417) on the knob domain of fiber-1 protein were identified and the key amino acid residues in the epitopes were determined. Structural analysis showed that the two adjacent epitopes 319SDVGYLGLPPH329 and 328PHTRDNWYV336 were exposed on the surface of the fiber-1 knob trimer, whereas the epitope 407VTTGPIPFSYQ417 was located inside of the spatial structure.ConclusionThis was the first identification of B-cell epitopes on the knob domain of fiber-1 protein and these findings provided a sound basis for the development of subunit vaccines, therapeutics, and diagnostic methods to control FAdV infections.
Outcomes after noncardiac surgery in patients with left ventricular assist devices: a systematic review
Authors: Alamouti-Fard Emad , Garg Pankaj , Yazji John , Brigham Tara , Jacob Samuel , Wadiwala Ishaq J. , Pham Si M. 
Published: September 2024

BackgroundThe number of patients living with left ventricular assist devices (LVADs) has gradually increased in the past decade. Non-cardiac surgery (NCS) in patients with LVAD poses a unique situation with its inherent challenges.AimWe conducted a comprehensive review to investigate the perioperative complications and mortality associated with emergent or elective NCS in patients with LVAD.MethodA comprehensive literature search for any papers referring to continuous LVAD patients with NCS. All publications with at least five durable LVAD patients who had NCS were eligible for inclusion.ResultTwenty articles matching our criteria were found and included in our study. This systematic review included 6,476 LVAD patients who underwent 6,824 NCS. There were 5–3,216 LVAD patients with NCS in each study. The median age was between 39 and 65 years, and most of the patients (78.8%) were male. Thirty-day postoperative mortality ranged from 0% to 60%. Eight studies reported no death within the 30 days of the operation. Common complications include gastrointestinal (GI) bleeding, intracranial bleeding, infection, acute kidney injury (AKI), urinary tract infection (UTI), stroke, sepsis, pneumonia, and VAD exchange. Emergent abdominal surgery had the highest (up to 60%) mortality rate, and vascular and neurological operations had the highest complication rates. Due to the diverse range of patients in each publication and the combination of outcomes presented in various publications, a meta-analysis was not conducted.ConclusionIn LVAD patients, noncardiac surgery may be performed effectively and safely. LVAD patients who undergo non-cardiac surgery may require more transfusions due to their complex coagulopathies. However, perioperative management of LVAD patients undergoing emergent NCS should be optimized to reduce mortality.Systematic Review Registrationhttps://osf.io/fetsb/.
The hidden impact: the rate of nicotine metabolism and kidney health
Authors: Wang Xiaona , Su Shanshan 
Published: September 2024

ObjectivesThe effects of nicotine metabolism on the kidneys of healthy individuals have not been determined. The nicotine metabolite ratio (NMR) indicates the rate of nicotine metabolism and is linked to smoking behaviors and responses to tobacco treatments. We conducted this study in order to investigated the relationship between nicotine metabolite ratio (NMR) and kidney function.MethodsAn analysis of cross-sectional data of adults was conducted using a population survey dataset (National Health and Nutrition Examination Survey Data 2013/2018 of the United States). A weighted multivariate regression analysis was conducted to estimate the correlation between NMR and kidney function. Furthermore, we apply fitting smooth curves to make the relationship between NMR and estimated glomerular filtration rate (eGFR) more visualized.ResultsThe research included a total of 16153 participants. Weighted multivariate regression analyses adjusted for possible variables showed a negative relationship between NMR and estimated glomerular filtration rate (eGFR).The β (95%CI) of the regression equation between NMR and eGFR was -2.24 (-2.92, -1.55), the trend testing showed consistent results. NMR is positively correlated with urinary albumin creatinine ratio (uACR), but it is not statistically significant. A stratified analysis found a negative correlation between NMR and eGFR in all age, gender and diabetes subgroups, the results were not statistically significant among Mexican Americans and other races. Notably, each unit rise in NMR corresponded to a 4.54 ml/min·1.73m² lower eGFR in diabetic participants and a 6.04 ml/min·1.73m² lower eGFR in those aged 60 and above.ConclusionsOur study shows that nicotine metabolite ratio is negatively associated with kidney function among most adults. It will be necessary to conduct more well-designed prospective clinical trials in order to determine the exact causal interactions between NMR and kidney function. Specific mechanisms also need to be further explored in basic experiments.
The efficacy of orally administered L-carnitine in alleviating ovarian dysfunctions has laid the foundation for targeted in vivo use: a study employing self-control and propensity score matching
Authors: Zhao Wenjie , Liu Kunkun , Zhang Yuhua , Sun Pingping , Zeringue Ernest , Meng Li , Ma Huagang 
Published: September 2024

ObjectiveThis study aimed to evaluate the effectiveness of oral L-carnitine administration in patients after treatment failure to lay the groundwork for targeted in vivo use.Methods and materialsA total of 515 In Vitro Fertilization (IVF) patients undergoing subsequent cycles were included after applying exclusion criteria. They were divided into a control group of 362 patients and a study group of 153 patients who received oral L-carnitine until oocyte retrieval.140 patients were matched according to maternal age, infertility duration, body mass index (BMI), day three top-quality embryos rate, by propensity score matching (PSM). The study investigated the relationship between L-carnitine treatment and in vivo oocyte maturation, normal fertilization, and subsequent embryo development.ResultsFollowing PSM, initial differences in BMI and Day3 top-quality embryo rate between groups were nullified, we created two comparable cohorts with highly similar characteristics. In the subsequent cycles, the study group showed significant improvements in in vivo oocyte maturation rate at retrieval (p=0.002), normal in vitro fertilization rate (p=0.003), blastocyst formation rate (p=0.003), and usable blastocyst rate compared to controls. Although there was no significant difference in the top-quality embryo rate on Day 3, the study group showed a 10% increase in the upper quartile (55.35% vs. 66.67%). The cumulative clinical pregnancy and live birth rates showed a significant improvement (59.82% vs. 68.42%,p=0.004, 47.41% vs. 59.80%, p=0.002). Furthermore, self-control analysis revealed substantial enhancements (p&lt;0.001) in all outcome measures following L-carnitine administration, resulting in the birth of 74 healthy neonates without congenital anomalies.ConclusionWe theorized that daily oral intake of L-carnitine before oocyte retrieval could boost oocyte quality and embryonic development, thus improving IVF outcomes. Ongoing investigations hold the potential to offer valuable insights into the applications and mechanisms underlying the therapeutic effectiveness of L-carnitine.
Comprehensive review of Korean Medicine registries 2015–2023
Authors: Kim Soo-Dam , Choi Sunmi , Kim Sungha 
Published: September 2024

BackgroundDespite the increasing popularity of Korean Medicine (KM), its scientific evidence faces scrutiny. Instead of randomized controlled trials, registries are favored to capture the real world of KM practice due to the difficulties associated with proper control and the holistic nature of the KM approach. This review aimed to examine the KM registries in detail, identify the scope and focus of studies within this field, and assess the research trends.MethodsWe conducted a comprehensive analysis of KM registries listed in trial registration platforms, covering records from their inception until the end of 2023. The selection criteria aimed to include studies focusing on various interventions related to KM, with data extraction focusing on study characteristics and outcomes measured. The analysis utilized descriptive statistics to summarize the findings.ResultsWe identified a steady increase in registry studies (2015, one; 2023, seven). Musculoskeletal disorders were most studied (28%), aligning with patients’ demand. The involvement of 112 primary clinics and Quality of Life (QOL) as the predominant outcome in 14 (66.7%) registries demonstrates the positive impact on patient well-being and the critical role that primary clinics play in KM practice.ConclusionOur findings indicate a heightened interest and commitment to evidence-based KM practices. Future Registries should be implemented on a large scale, incorporating long-term follow-up encompassing primary clinics. This approach would enable a comprehensive evaluation of the effectiveness and safety of KM interventions, as well as offer valuable insights into the influence of KM on chronic conditions and QOL.
Segmental vitiligo distribution follows the underlying arterial blood supply territory: a hypothesis based on anatomo-clinical, pathological and physio-pathological studies
Authors: Benzekri Laila , Cario-André Muriel , Laamrani Fatima Zahrae , Gauthier Yvon 
Published: September 2024

BackgroundSegmental vitiligo (SV) is a subset of vitiligo typically characterized by its unilateral distribution. The pathogenesis of SV remains unclear, and until now the two main patterns proposed for SV have lacked biological support. This calls for a new approach.ObjectivesUse data obtained from anatomo-clinical, pathological, and physio-pathological studies to formulate a new hypothesis on segmental vitiligo distribution and its pathogenesis.MethodsUsing transparent templates of local arterial blood supply, we evaluated anatomical correspondence (AC) in 140 SV lesions according to the number of SV lesions that fit within the corresponding arterial blood-supply areas. SV lesions were graded as 1 (moderate: AC &lt; 50%), 2 (good: AC &gt; 50%), or 3 (excellent: AC of all lesions). To support this anatomical investigation, we searched for complementary assessments according to the activity of SV lesions. Arterial and periarterial network impairment and inflammatory infiltration were histologically studied using nerve growth factor (NGF) and CD4 and CD8 monoclonal antibodies. Increased blood flow of the underlying arteries was also investigated using thermography and ultrasonography.ResultsWe recruited 140 patients with a sex ratio of 0.8 and mean age 26.13 years. Localizations: head and neck 84.28%; trunk 6.42%; upper limb 5%; genital areas 2.14%; lower limb 1.42%. The AC of each SV lesion with the underlying artery blood supply territory was rated as 72% excellent; 16% good; and 12% moderate. Histologically (40 patients), we found some periarterial network impairments. Thermal asymmetry was significantly associated with active SV (p &lt; 0.001).ConclusionWe hypothesized that SV distribution corresponds to the underlying artery blood-supply territory.