bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of microRNAs in prethrombotic status associated with coronary artery disease
Authors: Gao Jie , Ma Xiaojuan , Zhang Ying , Guo Ming , Shi Dazhuo 
Published: December 2016

SummaryThe acute cardiovascular events following thrombus formation is a primary cause of morbidity and mortality of patients with coronary artery disease (CAD). Numerous studies have shown that a prethrombotic status, which can be defined as an imbalance between the procoagulant and anticoagulant conditions, would exist for a period of time before thrombogenesis. Therefore, early diagnosis and intervention of prethrombotic status are important for reducing acute cardiovascular events. However, none of prethrombotic indicators have been identified as golden standard for diagnosis of prethrombotic status to date. MicroRNAs (miRNAs), a class of short non-coding RNAs, have been shown to be involved in pathophysiologic processes related to prethrombotic status, such as endothelial dysfunction, platelet activation, impaired fibrinolysis and elevated procoagulant factors, etc. Owing to their multiple and fine-tuning impacts on gene expression, miRNAs raise a novel understanding in the underlying mechanism of prethrombotic status. This review aims to discuss the role of miRNAs in prethrombotic status, especially the differently expressed miRNAs in CAD, which may be meaningful for developing promising diagnostic biomarkers and therapeutic strategies for CAD patients in future.
D-dimer and the Risk of Stroke and Coronary Heart Disease
Authors: McClure Leslie A. , Judd Suzanne E. , Kissela Brett , Howard George , Safford Monika M. , Cushman Mary , Zakai Neil A. 
Published: December 2016

SummaryD-dimer, a biomarker of coagulation, is higher in blacks than in whites and has been associated with stroke and coronary heart disease (CHD). It was our objective to assess the association of higher D-dimer with stroke and CHD in blacks and whites. REGARDS recruited 30,239 black and white participants across the contiguous US and measured baseline D-dimer in stroke (n=646) and CHD (n=654) cases and a cohort random sample (n=1,104). Cox models adjusting for cardiovascular risk factors determined the hazard ratio (HR) for increasing D-dimer for cardiovascular disease with bootstrapping to assess the difference in HR for CHD versus stroke by race. D-dimer was higher with increasing age, female sex, diabetes, hypertension, pre-baseline cardiovascular disease and higher C-reactive protein (CRP). Accounting for cardiovascular risk factors, each doubling of D-dimer was associated with increased stroke (hazard ratio [HR] 1.15; 95 % confidence interval [CI] 1.01, 1.31) and CHD (HR 1.27; 95 % CI 1.11, 1.45) risk. The difference in the HR between CHD and stroke was 0.20 (95 % CI >0.00, 0.58) for blacks and 0.02 (95 % CI –0.30, 0.27) for whites. CRP mediated 22 % (95 % CI 5 %, 41 %) of the association between D-dimer and CHD and none of the association with stroke. Higher D-dimer increased the risk of stroke and CHD independent of cardiovascular risk factors and CRP, with perhaps a stronger association for CHD versus stroke in blacks than whites. These findings highlight potential different pathophysiology of vascular disease by disease site and race suggesting potential further studies targeting haemostasis in primary prevention of vascular disease.
Beckett, pedagogo do ator: práticas de esgotamento
Authors: Lima Tatiana Motta 
Published: December 2016

Os textos de Samuel Beckett convidam o ator a descobrir lugares insuspeitados do ser. Eles podem ser vistos como mapas que indicam modos de ser/fazer ou, dizendo de outra maneira, modos de subjetivação que “bagunçam” nossas ideias/práticas mais imediatas de indivíduo, sujeito, personalidade, e, portanto, de ator/atuação e de formação de atores. O que está em jogo são novas relações entre textualidade, oralidade, corporeidade e subjetivação. Nesse sentido, Beckett pode ser visto com um pedagogo (ainda que muito sui generis) do ator. Seus textos podem ser pensados como pedagógicos, já que ensinam/convocam a uma atuação “outra”: múltipla, desmembrada, falhada, apagada, extremamente autoconsciente e que, ao mesmo tempo, acha “alegre ainda não ter estabelecido com o menor grau de precisão o que é”. Uma das perguntas centrais dessa pedagogia beckettiana poderia ser: como formar o ator sem produzir uma reificação individualista? Como formá-lo promovendo – e/ou a partir de – novos modos de subjetivação?
Endothelial Function Assessed by Automatic Measurement of Enclosed Zone Flow‐Mediated Vasodilation Using an Oscillometric Method Is an Independent Predictor of Cardiovascular Events
Authors: Morimoto Haruka , Kajikawa Masato , Oda Nozomu , Idei Naomi , Hirano Harutoyo , Hida Eisuke , Maruhashi Tatsuya , Iwamoto Yumiko , Kishimoto Shinji , Matsui Shogo , Aibara Yoshiki , Hidaka Takayuki , Kihara Yasuki , Chayama Kazuaki , Goto Chikara , Noma Kensuke , Nakashima Ayumu , Ukawa Teiji , Tsuji Toshio , Higashi Yukihito 
Published: December 2016

Background

A new device for automatic measurement of flow‐mediated vasodilation (
FMD
) using an oscillometric method has been developed to solve technical problems of conventional
FMD
measurement. This device measures enclosed zone FMD (ez
FMD
). The purpose of this study was to evaluate the prognostic value of endothelial function assessed by ez
FMD
for future cardiovascular events.

Methods and Results

We measured ez
FMD
in 272 participants who underwent health‐screening examinations. First, we investigated cross‐sectional associations between ez
FMD
and cardiovascular risk factors, and then we assessed the associations between ez
FMD
and first major cardiovascular events (death from cardiovascular causes, stroke, and coronary revascularization). Univariate regression analysis revealed that ez
FMD
was significantly correlated with age, triglycerides, glucose, smoking pack‐years, estimated glomerular filtration rate, high‐sensitivity C‐reactive protein, and Framingham risk score. During a median follow‐up period of 36.1 months (interquartile range 18.8–40.1 months), 12 participants died (6 from cardiovascular causes), 3 had stroke, 8 had coronary revascularization, and 10 were hospitalized for heart failure. There was no episode of acute coronary syndrome during the study period. Participants were divided into tertiles (low, intermediate, and high) based on ez
FMD
. Kaplan–Meier curves for first major cardiovascular events among the 3 groups were significantly different (
P
=0.004). After adjustment for cardiovascular risk factors, the low group was significantly associated with an increased risk of first major cardiovascular events compared with the high group (hazard ratio 6.47; 95% CI 1.09–125.55;
P
=0.038).

Conclusions

These findings suggest that endothelial function assessed by ez
FMD
may be useful as a surrogate marker of future cardiovascular events.

Clinical Trial Registration

URL
:
https://upload.umin.ac.jp
. Unique identifier:
UMIN
000004902.
Searching for the Elusive? Examining the Right to Health’s Status in the Pacific
Authors: Kallie Jennifer Y , Brolan Claire E , Richards Nicola C 
Published: December 2016

Integrating the right to health is pivotal in progressing health and development in the Pacific. The Sustainable Development Goal (sdg) agenda provides an opportunity for this, given the relationship between health, human rights, climate change and sustainable development. The right to health’s content can be utilised to progress country obligations in various ways: through facilitating implementation of Universal Health Coverage, supporting the development of health metrics, and assisting in equitable health policies. Cumulatively, such measures can act as process and outcome indicators of a state’s progressive realisation toward achieving the right to health.
In analysing the status of the law and policy relating to the right to health, this study has established a right to health baseline for the Pacific region at sdg commencement, contributing both to monitoring and evaluation, and promoting visibility of this often overlooked region. Methods included a systematic review of the literature on the right to health, and review of six structural rights indicators in existing law and policy relating to the right to health in the 16 Pacific Island Forum countries and territories, 14 of which are recognised as small island developing states. Findings confirm the right to health’s marginalisation in the region. The ratification of United Nations (un) treaties, integration of international human rights obligations into domestic law and policy, and compliance with reporting requirements were found to be piecemeal and ad hoc at best.
We argue that while legal recognition is only one step in the process of realising the right to health, the existence of right to health law and policy is a pivotal start if there is to be equitable implementation of the sdg health agenda. We also recommend Pacific nations develop one reporting framework, which can double to meet their reporting requirements under un treaty bodies and sdg 3 global health commitments.
Block network mapping approach to quantitative trait locus analysis
Authors: Shreif Zeina Z. , Gatti Daniel M. , Periwal Vipul 
Published: December 2016

Abstract
Background
Advances in experimental biology have enabled the collection of enormous troves of data on genomic variation in living organisms. The interpretation of this data to extract actionable information is one of the keys to developing novel therapeutic strategies to treat complex diseases. Network organization of biological data overcomes measurement noise in several biological contexts. Does a network approach, combining information about the linear organization of genomic markers with correlative information on these markers in a Bayesian formulation, lead to an analytic method with higher power for detecting quantitative trait loci?

Results
Block Network Mapping, combining Similarity Network Fusion (Wang et al., NM 11:333–337, 2014) with a Bayesian locus likelihood evaluation, leads to large improvements in area under the receiver operating characteristic and power over interval mapping with expectation maximization. The method has a monotonically decreasing false discovery rate as a function of effect size, unlike interval mapping.

Conclusions
Block Network Mapping provides an alternative data-driven approach to mapping quantitative trait loci that leverages correlations in the sampled genotypes. The evaluation methodology can be combined with existing approaches such as Interval Mapping. Python scripts are available at http://lbm.niddk.nih.gov/vipulp/. Genotype data is available at http://churchill-lab.jax.org/website/GattiDOQTL.
LO POLÍTICO EN LA EDUCACIÓN MATEMÁTICA: DE LA EDUCACIÓN MATEMÁTICA CRÍTICA A LA POLÍTICA CULTURAL DE LA EDUCACIÓN MATEMÁTICA
Authors: Valero Paola , Andrade-Molina Melissa , Montecino Alex 
Published: December 2016

Este artículo ofrece una ref lexión sobre los movimientos que ha configurado una visión crítica y política en educación matemática. Realizamos un mapeo de los puntos sobresalientes, por un lado, de la educación matemática crítica, su desarrollo en el mundo y en América Latina, sus preocupaciones, tensiones y nuevas direcciones. Por el otro, introducimos el giro hacia el estudio de la política cultural de la educación matemática. Esta tendencia permite problematizar, desde perspectivas histórico-culturales, cómo las prácticas educativas de las matemáticas contribuyen a la formación de los sujetos racionales de nuestro tiempo e insertan a las personas en formas de conocer y racionalidades matemáticas socialmente valoradas. El estudio político de la educación matemática en su totalidad ofrece maneras de entender e imaginar los distintos aspectos filosóficos, sociológicos y pedagógicos de las matemáticas escolares.
ANALYSIS OF IMPROVEMENT ELEMENTS OF WALKING ENVIRONMENT ON KOREA TRADITONAL MARKETS USING ANALYTIC HEIRARCHY PROCESS
Authors: Chung Kumho , Yoon Min-Suk 
Published: December 2016

In this paper, we evaluate elements to improve pedestrian mobility in order to revitalize traditional markets in South Korea. The objective of this study is to analyze the priority of elements for pedestrians in traditional markets using the Analytic Hierarchy Process (AHP). This paper used a two level hierarchy structure to achieve the objective. The first level was composed of four elements and the second level was composed of 28 sub-elements. The questionnaire used pairwise comparison. The data for analysis was collected through a survey of university students. The AHP process produced the results of this study as follows. The elements in the first level of element priority are interest, convenience, comfort and safety. The sub-elements in the second level of element priority are pitchmen, street vendors, shopping, price negotiation, paving, landscape, street lights, benches, people watching, trash bins, street vegetation, obstacles, information signs, illegal parking, cul-de-sacs, noise, sidewalk width, crowdedness, lack of sidewalk, sidewalk slope, activities, public transportation, traffic, pedestrians, stalls, billboards, vehicle speed, parking lots, speed bumps, and bicycle roads.
A VENDOR'S EVALUATION–USING AHP FOR AN INDIAN STEEL PIPE MANUFACTURING COMPANY
Authors: KAMATH GIRIDHAR B , NAIK RAKESH , PRASAD SHIVA 
Published: December 2016

To improve a firm’s supply chain performance it is essential to have a vendor evaluation process to be able to showcase an organization’s success in the present aggressive market. Hence, the process of evaluating the vendor is a crucial task of the purchasing executives in supply chain management. The objective of this research is to propose a methodology to evaluate the vendors for a steel pipe manufacturing firm in Gujarat, India. For the purpose of the study, the Analytical Hierarchy Process was used to evaluate the best raw material vendor for this company. Multiple qualitative and quantitative criteria are involved in the vendor evaluation process. To solve the complex problem of vendor evaluation, a tradeoff between these multi-criteria is important. The outcomes indicated that the AHP technique makes it simpler to assign weights for the different criteria for evaluating the vendor. Research findings showed that quality is the most important criterion followed by delivery, cost and vendor relationship management.
Medpoklicno izobraževanje zaposlenih v nujni medicinski pomoči
Authors: Železnjak Vladka , Skela-Savič Brigita 
Published: December 2016

Uvod: Izobraževalni sistem za delo v zdravstvenem timu nujne medicinske pomoči v Sloveniji ima pomanjkljivosti in potrebuje spremembe. Namen raziskave je bil ugotoviti vsebine teoretičnih znanj in praktičnih veščin, za katere bi se morali izobraževati in usposabljati člani vseh poklicnih skupin tako v času šolanja kot v času opravljanja dela v nujni medicinski pomoči.
Metode: Uporabljena je bila triangulacija metod; kvalitativna metoda z uporabo delno strukturiranega intervjuja kot tehnike zbiranja podatkov med 30 zaposlenimi v timu nujne medicinske pomoči ter metoda delfi za ugotavljanje in usklajevanje mnenj o predlaganih ukrepih v sedmih vsebinskih sklopih pri 27 respondentih, razdeljenih v tri skupine: zaposleni v enotah nujne medicinske pomoči, vodje enot nujne medicinske pomoči, oblikovalci zdravstvene politike. Metoda delfi je bila izvedena v dveh krogih.
Rezultati: Sodelujoči v raziskavi so mnenja, da je v času šolanja pridobljenega premalo znanja in veščin za delo v nujni medicinski pomoči. Menijo, da bi bil s spremembo izobraževalnega sistema ter uvedbo medpoklicnega izobraževanja tako v času šolanja kot v času zaposlitve sistem izvajanja nujnih ukrepov učinkovitejši.
Diskusija in zaključek: Strokovnjaki s področja nujne medicinske pomoči predlagajo dobre prakse drugih organizacijskih in izobraževalnih modelov, tj. skupno izvajanje kliničnih vaj iz urgentne medicine in medpoklicno izobraževanje s simulacijskimi scenariji za vse poklicne skupine, sodelujoče v enotah nujne medicinske pomoči.
Investigation of variations in terms of decision making and trait anxiety level of football referees<p>Futbol hakemlerinin karar verme ve sürekli kaygı düzeylerinin bazı değişkenler açısından incelenmesi
Authors: Yalçın İlimdar , Soyer Fikret , Ramazanoğlu Fikret , Aksu Atakan 
Published: December 2016

This study has been done in the purpose of investigation the decision making and trait anxiety level of football referees under some variations.Study has been applied to 72 football referees out of 89 (%80.8), regional and national referees, whom work from East and South Easter Anatolian region in 8th and 13th sections.In the study, Mann et al. (1998), “Melbourne Decision Making Scale” adapted by Deniz (2004) and Turkish “Trait Anxiety Inventory” adapted by Türker, Öner and Le Compte (1983) developed by Spielberger and friends. SPSS 22 package program was used to analyze the data obtained in the study and the level of significance was taken as p <0.05. T-test and One-Way Anova were used in the study.As the result of the analysis, in decision making process, the education of self-respect and high attention favors the referees. Those whom has worked more, thus have more experience, tend to have a higher level of decision making. It has been determined that as the age progresses at the level of trait anxiety, there is a regular decrease in trait anxiety level. It has been determined that the level of trait anxiety of the referees who have graduate education level is lower than that of the referees who have undergraduate and graduate degrees. ÖzetBu çalışma, bölgesel ve ulusal futbol hakemlerin karar verme ve sürekli kaygı düzeylerinin bazı değişkenler açısından incelemesi amacıyla yapılmıştır.Araştırma, Doğu ve Güneydoğu Anadolu Bölgesi'nde 8. ve 13. Bölge’de bulunan bölgesel ve ulusal futbol hakemi olan toplam 89 hakemden 72 (% 80,8) hakeme uygulanmıştır.Çalışmada, Mann ve Ark. (1998) tarafından geliştirilmiş olup, Deniz (2004) tarafından Türkçeye uyarlanan ''Melbourne Karar Verme Ölçeği'' ve Spielberger ve arkadaşları (1970) tarafından geliştirilen Öner ve Le Compte (1983) tarafından Türkçeye uyarlanan ''Sürekli Kaygı Envanteri'' kullanılmıştır. Araştırmada elde edilen verileri analiz etmek için SPSS 22 paket programı kullanılmış olup anlamlılık düzeyi p<0.05 olarak alınmıştır. Çalışmada t testi ve One -Way Anova kullanılmıştır.Çalışma sonucunda, Karar vermede özsaygı ve dikkatli karar verme düzeylerinde eğitim düzeyi üst seviyede olmasının hakemler lehine önemli bir faktör olduğu tespit edilmiştir. Hakemlik yılı fazla olan futbol hakemlerinin dikkatli karar verme düzeyinin yüksek olduğu gözlenmiştir. Sürekli kaygı düzeyinde yaş ilerledikçe sürekli kaygı düzeyinde de düzenli bir düşüşün olduğu tespit edilmiştir. Eğitimi düzeyi yüksek lisans olan hakemlerin sürekli kaygı düzeyi eğitim durumu ön lisans ve lisans olan hakemlere göre daha düşük olduğu tespit edilmiştir.
The relationship between schools' DNA profiles and political behavior in school<p>Okulların DNA profili ile okul içi politik davranışlar arasındaki ilişki
Authors: Bozkurt Bostancı Aynur , Akçadağ Tuncay , Kahraman Ümit , Tosun Ali 
Published: December 2016

This research was conducted to determine the relationship between schools' DNA profiles and school political behavior, according to teacher opinions. The research is in the relational screening model. The universe of the research is formed by the teachers working in Usak-Turkey. The sample of the research is composed of 361 primary, secondary and high school teachers working in Usak. Sampling was made easy to reach in the research. According to the results of the research, teachers generally view the organization DNA profile of schools as a flexible organization type. Schools carry the characteristics of healthy organizational types at moderate level and those of unhealthy organizational type at low level. Teachers, however, have never met the political behavior of the upper management within the school to try to get involved and to look for mutual benefit. They have rarely seen their behavior like acting as a coercive, trying to get into the eye and forming a coalition. Again in the research, according to the opinions of the teachers, it was revealed that there is a relationship between the School's DNA profiles and the school's political behavior. There was a negative correlation between the types of school healthy organizations and political behavior, while there was a positive moderate relationship between the types of unhealthy organizations and the appearance of political behavior. ÖzetBu araştırma öğretmen görüşlerine göre, okulların DNA profili ile okul içi politik davranışlar arasında ilişkinin belirlenmesi amacıyla yapılmıştır. Araştırma ilişkisel tarama modelindedir. Araştırmanın evrenini Uşak’ta görev yapan öğretmenler, örneklemi ise 361 ilkokul, ortaokul ve lise öğretmeni oluşturmaktadır. Araştırmada kolay ulaşılabilir örnekleme yoluna gidilmiştir. Araştırma sonuçlarına göre, öğretmenler okulların örgüt DNA’sı profilini esnek örgüt tipinde görmektedirler. Okullar sağlıklı örgüt tiplerinin özelliklerini orta düzeyde, sağlıksız örgüt tipi özelliklerini ise az düzeyinde taşımaktadırlar. Bunun yanında öğretmenler, okul içerisinde üst yönetime yaranmaya çalışmak ve karşılıklı çıkar gözetmek boyutlarındaki politik davranışlara okul içinde hiçbir zaman rastlamadıklarını, tavizci davranmak, göze girmeye çalışmak ve koalisyon kurmak gibi davranışları ise nadiren düzeyinde gördüklerini belirtmişlerdir. Yine araştırmada öğretmen görüşlerine göre, Okul DNA profilleri ile politik davranışlar arasında ilişki bulunduğu ortaya konulmuştur. Okulda sağlıklı örgüt tipleri ile politik davranışları arasında negatif yönlü düşük dereceli bir ilişki bulunurken, sağlıksız örgüt tipleri ile politik davranışların görülme durumu arasında pozitif yönlü orta dereceli bir ilişkiye rastlanmıştır.
A novel diffusion‐tensor MRI approach for skeletal muscle fascicle length measurements
Authors: Oudeman Jos , Mazzoli Valentina , Marra Marco A. , Nicolay Klaas , Maas Mario , Verdonschot Nico , Sprengers Andre M. , Nederveen Aart J. , Strijkers Gustav J. , Froeling Martijn 
Published: December 2016

AbstractMusculoskeletal (dys‐)function relies for a large part on muscle architecture which can be obtained using Diffusion‐Tensor MRI (DT‐MRI) and fiber tractography. However, reconstructed tracts often continue along the tendon or aponeurosis when using conventional methods, thus overestimating fascicle lengths. In this study, we propose a new method for semiautomatic segmentation of tendinous tissue using tract density (TD). We investigated the feasibility and repeatability of this method to quantify the mean fascicle length per muscle. Additionally, we examined whether the method facilitates measuring changes in fascicle length of lower leg muscles with different foot positions. Five healthy subjects underwent two DT‐MRI scans of the right lower leg, with the foot in 15° dorsiflexion, neutral, and 30° plantarflexion positions. Repeatability of fascicle length measurements was assessed using Bland–Altman analysis. Changes in fascicle lengths between the foot positions were tested using a repeated multivariate analysis of variance (MANOVA). Bland–Altman analysis showed good agreement between repeated measurements. The coefficients of variation in neutral position were 8.3, 16.7, 11.2, and 10.4% for soleus (SOL), fibularis longus (FL), extensor digitorum longus (EDL), and tibialis anterior (TA), respectively. The plantarflexors (SOL and FL) showed significant increase in fascicle length from plantarflexion to dorsiflexion, whereas the dorsiflexors (EDL and TA) exhibited a significant decrease. The use of a tract density for semiautomatic segmentation of tendinous structures provides more accurate estimates of the mean fascicle length than traditional fiber tractography methods. The method shows moderate to good repeatability and allows for quantification of changes in fascicle lengths due to passive stretch.