bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distal radio-ulnar implant arthroplasty: a systematic review
Authors: Moulton L.S. , Giddins G.E.B. 
Published: February 2017

The use of implant arthroplasty in the hand and wrist is increasing, often with little evidence of outcomes in the literature. We therefore undertook a systematic review of the outcomes of distal radio-ulnar joint arthroplasties following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Papers were assessed for outcomes, implant survival and methodological quality. Fourteen papers assessed ulna head replacements. The implant survival rate was 93% at a mean follow-up of 45 months. One paper assessed a partial ulna head replacement. Fourteen papers assessed total distal radio-ulnar joint replacements; all but two used the Aptis prosthesis. These implants had a survival rate of 97% at a mean of 56 months. Complications rates were 28% in both groups, and many were major. Although these data are impressive, worldwide there are many more implants placed and not followed up. All studies were level IV and V studies with low Coleman scores. This systematic review demonstrates that implant arthroplasty for the distal radio-ulnar joint has produced acceptable results in small numbers of patients. Whilst these short term outcomes are encouraging, the indications should be carefully considered and there should be proper consideration of the potential for later failure. Level of evidence: III
Can Direct Current Electrotherapy Be Used for Patients With Orthopedic Implants?
Authors: Thaler Evangeline , Toledo Felippe , Korte Holger 
Published: February 2017

Introduction: Although electrotherapy appears to have particularly interesting applications in the field of postoperative orthopedic rehabilitation, relatively little scientifically based research has been conducted in the area of electrotherapy with regard to safety involving patients with orthopedic implants. Method: Three electrotherapy forms were tested, such as high-volt stimulation (HVS), transcutaneous electric nerve stimulation (TENS), and galvanic current (GAL), using a model system containing a metal implant plate to evaluate whether heating in excess of 3°C would occur. Results: All changes in temperature for HVS, GAL, and TENS therapeutic electrical currents observed in our model system fall below the predefined 3°C. Conclusion: To the best of our knowledge, this is the first experimental based observation that prolonged exposure to a direct electrical current at therapeutic strength does not result in heating of metal titanium plates.
Seasonal Variation in Hip Fracture Mortality
Authors: Yee Dennis K. H. , Fang Christian , Lau T. W. , Pun Terence , Wong T. M. , Leung Frankie 
Published: February 2017

Objectives: This study aims to identify if wintertime surgery increases the mortality of the patients after hip fracture operations. Design: Retrospective observational cohort study. Setting: The data for this citywide retrospective observational cohort study came from Clinical Data Analysis Reporting System. Patient: This study included 35 409 patients with hip fracture operations from July 2005 to December 2013. Main Outcome Measures: Cox regression hazard model was used to estimate the independent effect of operation being performed in winter on the hazard of mortality. The hazard model included covariates found to be independent predictors of mortality: age, sex, surgical delay, and Charlson Comorbidity Index (CCI). Results: There was a seasonal variation with more hip fracture operations happening in the winter months. The 1-month, 6-month, 1-year, and 5-year mortality were 3%, 11%, 17%, and 47%, respectively. Operation performed in winter was associated with a higher hazard of mortality (hazard ratio [HR] 1.040; 95% confidence interval: 1.010-1.072; P = .009). The HR was greater with male sex (HR 1.786; P = .000), advanced age (≥85 years old: HR 2.819; P = .000), the longer surgical delay (HR 1.018; P = .000), and higher CCI (severe CCI group: HR 2.963; P = .000). Conclusion: Wintertime hip fracture surgery was associated with an increased hazard of mortality after adjusting for other known risk factors affecting mortality post hip fracture operations.
Specific factor IX mRNA and protein features favor drug-induced readthrough over recurrent nonsense mutations
Authors: Branchini Alessio , Ferrarese Mattia , Campioni Matteo , Castaman Giancarlo , Mari Rosella , Bernardi Francesco , Pinotti Mirko 
Published: February 2017

Key PointsOnly a few F9 nonsense mutations are responsive to drug-induced readthrough due to specific translation and protein structural constraints. Reinsertion of the WT residue and gain-of-function effects account for functionally relevant readthrough.
Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms
Authors: Tesi Bianca , Davidsson Josef , Voss Matthias , Rahikkala Elisa , Holmes Tim D. , Chiang Samuel C. C. , Komulainen-Ebrahim Jonna , Gorcenco Sorina , Rundberg Nilsson Alexandra , Ripperger Tim , Kokkonen Hannaleena , Bryder David , Fioretos Thoas , Henter Jan-Inge , Möttönen Merja , Niinimäki Riitta , Nilsson Lars , Pronk Cornelis Jan , Puschmann Andreas , Qian Hong , Uusimaa Johanna , Moilanen Jukka , Tedgård Ulf , Cammenga Jörg , Bryceson Yenan T. 
Published: February 2017

Key Points
Autosomal-dominant SAMD9L gain-of-function mutations predispose to myeloid malignancies involving chromosome 7 aberrations. Hematopoietic reversions frequently occur postnatally and are associated with milder disease manifestations.
Multi-jet electrospinning of polystyrene/polyamide 6 blend: thermal and mechanical properties
Authors: Yoon Jae Won , Park Yaewon , Kim Jooyoun , Park Chung Hee 
Published: February 2017

AbstractPolystyrene (PS) has high thermal resistance thus can be applied as thermally comfortable textile. However, the application is limited due its low mechanical strength. In this study, polyamide 6 (PA6) was blended with PS to improve the mechanical strength of PS, by means of a multi-jet electrospinning. Content ratio of the blend web was measured by chemical immersion test and confocal microscopy analysis. Fiber content was in accordance with the number of syringes used for PS and PA6 respectively. The effects of content ratio on the web morphology, thermal resistance, tensile behavior, air and water vapor permeability, and surface hydrophilicity were investigated. The influence of environmental humidity during electrospinning process on three dimensional (3D) web structure was also reported. PS web produced from higher humidity had more pores and corrugations at the surface. The increased surface roughness and porosity led to the increased hydrophobicity and thermal resistance. Though the blending of PA6 with PS enhanced the mechanical strength, the added PA6 decreased air/water vapor permeability and thermal resistance. The lowered thermal resistance by the addition of PA6 was mainly attributed to higher thermal conductivity of PA6 material and lowered air content with PA6 fibers.
Personal Genomic Testing for Cancer Risk: Results From the Impact of Personal Genomics Study
Authors: Gray Stacy W. , Gollust Sarah E. , Carere Deanna Alexis , Chen Clara A. , Cronin Angel , Kalia Sarah S. , Rana Huma Q. , Ruffin Mack T. , Wang Catharine , Roberts J. Scott , Green Robert C. 
Published: February 2017

Purpose Significant concerns exist regarding the potential for unwarranted behavior changes and the overuse of health care resources in response to direct-to-consumer personal genomic testing (PGT). However, little is known about customers’ behaviors after PGT. Methods Longitudinal surveys were given to new customers of 23andMe (Mountain View, CA) and Pathway Genomics (San Diego, CA). Survey data were linked to individual-level PGT results through a secure data transfer process. Results Of the 1,042 customers who completed baseline and 6-month surveys (response rate, 71.2%), 762 had complete cancer-related data and were analyzed. Most customers reported that learning about their genetic risk of cancers was a motivation for testing (colorectal, 88%; prostate, 95%; breast, 94%). No customers tested positive for pathogenic mutations in highly penetrant cancer susceptibility genes. A minority of individuals received elevated single nucleotide polymorphism-based PGT cancer risk estimates (colorectal, 24%; prostate, 24%; breast, 12%). At 6 months, customers who received elevated PGT cancer risk estimates were not significantly more likely to change their diet, exercise, or advanced planning behaviors or engage in cancer screening, compared with individuals at average or reduced risk. Men who received elevated PGT prostate cancer risk estimates changed their vitamin and supplement use more than those at average or reduced risk (22% v 7.6%, respectively; adjusted odds ratio, 3.41; 95% CI, 1.44 to 8.18). Predictors of 6-month behavior include baseline behavior (exercise, vitamin or supplement use, and screening), worse health status (diet and vitamin or supplement use), and older age (advanced planning, screening). Conclusion Most adults receiving elevated direct-to-consumer PGT single nucleotide polymorphism-based cancer risk estimates did not significantly change their diet, exercise, advanced care planning, or cancer screening behaviors.
Health-Related Quality of Life in Adolescent and Young Adult Patients With Cancer: A Longitudinal Study
Authors: Husson Olga , Zebrack Brad J. , Block Rebecca , Embry Leanne , Aguilar Christine , Hayes-Lattin Brandon , Cole Steve 
Published: February 2017

Purpose To examine changes in health-related quality of life (HRQoL) and its predictors during the first 2 years after initial cancer diagnosis in adolescent and young adult (AYA) patients with cancer. Patients and Methods A multicenter, longitudinal, prospective study was conducted among a diverse sample of AYA patients with cancer ages 15 to 39 years. One hundred seventy-six patients (75% response) completed a self-report measure of HRQoL (Short Form-36 [SF-36]) within the first 4 months after diagnosis and again 12 and 24 months later. Linear mixed models with random intercepts and slopes estimated changes in QoL. Results Recently diagnosed AYA patients with cancer had significantly worse physical component scale (PCS) scores (38.7 v 52.8; P < .001) and mental component scale (MCS) scores (42.9 v 48.9; P < .001) when compared with population norms. Significant improvements in PCS and MCS scores from baseline to 24-month follow-up were observed; however, these increases were largest during the first 12 months. At the 24-month follow-up, AYA patients still had significantly lower PCS scores (48.0 v 52.8; P < .001) and MCS scores (45.8 v 48.9; P = .002) when compared with population norms. Multivariable analyses revealed that improvements in PCS and MCS scores were primarily a function of being off-treatment and being involved in school or work. PCS but not MCS scores were worse for AYA patients diagnosed with cancers with poorer prognoses. Conclusion Although HRQoL improved over time, it was still compromised 24 months after primary diagnosis. Given relatively little observed improvement in HRQoL during the 12- to 24-month period after diagnosis, AYA patients may benefit from supportive care interventions administered during the second year after diagnosis.
Cabozantinib Versus Sunitinib As Initial Targeted Therapy for Patients With Metastatic Renal Cell Carcinoma of Poor or Intermediate Risk: The Alliance A031203 CABOSUN Trial
Authors: Choueiri Toni K. , Halabi Susan , Sanford Ben L. , Hahn Olwen , Michaelson M. Dror , Walsh Meghara K. , Feldman Darren R. , Olencki Thomas , Picus Joel , Small Eric J. , Dakhil Shaker , George Daniel J. , Morris Michael J. 
Published: February 2017

Purpose Cabozantinib is an oral potent inhibitor of vascular endothelial growth factor receptor 2, MET, and AXL and is a standard second-line therapy for metastatic renal cell carcinoma (mRCC). This randomized phase II multicenter trial evaluated cabozantinib compared with sunitinib as first-line therapy in patients with mRCC. Patients and Methods Eligible patients had untreated clear cell mRCC and Eastern Cooperative Oncology Group performance status of 0 to 2 and were intermediate or poor risk per International Metastatic Renal Cell Carcinoma Database Consortium criteria. Patients were randomly assigned at a one-to-one ratio to cabozantinib (60 mg once per day) or sunitinib (50 mg once per day; 4 weeks on, 2 weeks off). Progression-free survival (PFS) was the primary end point. Objective response rate (ORR), overall survival, and safety were secondary end points. Results From July 2013 to April 2015, 157 patients were randomly assigned (cabozantinib, n = 79; sunitinib, n = 78). Compared with sunitinib, cabozantinib treatment significantly increased median PFS (8.2 v 5.6 months) and was associated with a 34% reduction in rate of progression or death (adjusted hazard ratio, 0.66; 95% CI, 0.46 to 0.95; one-sided P = .012). ORR was 33% (95% CI, 23% to 44%) for cabozantinib versus 12% (95% CI, 5.4% to 21%) for sunitinib. All-causality grade 3 or 4 adverse events were 67% for cabozantinib and 68% for sunitinib and included diarrhea (cabozantinib, 10% v sunitinib, 11%), fatigue (6% v 15%), hypertension (28% v 22%), palmar-plantar erythrodysesthesia (8% v 4%), and hematologic adverse events (3% v 22%). Conclusion Cabozantinib demonstrated a significant clinical benefit in PFS and ORR over standard-of-care sunitinib as first-line therapy in patients with intermediate- or poor-risk mRCC.
Oocyte shuttle, a recombinant protein transporting donor DNA into theXenopusoocytein situ
Authors: Rungger Duri , Muster Lisbeth , Georgiev Oleg , Rungger-Brändle Elisabeth 
Published: February 2017

ABSTRACTThe newly developed oocyte shuttle protein contains a streptavidin moiety that tightly binds biotinylated DNA. Injected intravenously into adult Xenopus females, the protein-DNA complex is rapidly transported through the bloodstream and, within the ovary, the vitellogenin ligand present in the protein binds to the receptors at the surface of the oocytes. The bound complex is internalized and translocates into the oocyte nucleus thanks to an SV40 nuclear localization signal, enhanced by an adjacent casein kinase phosphorylation site. Functioning of the shuttle protein is documented by transporting DNA molecules that, upon intramolecular homologous recombination within the oocyte nucleus, express easily traceable markers such as green fluorescence or tetracycline resistance.
Naturalistic path integration of Cataglyphis desert ants on an air-cushioned lightweight spherical treadmill
Authors: Dahmen Hansjürgen , Wahl Verena L. , Pfeffer Sarah E. , Mallot Hanspeter A. , Wittlinger Matthias 
Published: February 2017

ABSTRACT
Air-cushioned spheres are widely used as treadmills to study behavioural and neurophysiological questions in numerous species. We describe an improved spherical treadmill design that reliably registers the path and walking behaviour of an animal walking on top of the sphere. The simple and robust set-up consists of a very light hollowed styrofoam ball supported by an air stream in a hollow half sphere and can be used indoors and outdoors. Two optical mouse sensors provided with lenses of 4.6 mm focal length detect the motion of the sphere with a temporal resolution of more than 200 frames s−1 and a spatial resolution of less than 0.2 mm. The treadmill can be used in an open- or closed-loop configuration with respect to yaw of the animal. The tethering allows animals to freely adjust their body posture and in the closed-loop configuration to quickly rotate around their yaw axis with their own moment of inertia. In this account, we present the first evidence of naturalistic homing navigation on a spherical treadmill for two species of Cataglyphis desert ants. We were able to evaluate with good precision the walking speed and angular orientation at any time. During homing the ants showed a significant difference in walking speed between the approach and search phases; moreover, they slowed down significantly as soon as they reached zero vector state, the fictive nest position.
Estimates of Within-Subject Biological Variation of Protein C, Antithrombin, Protein S Free, Protein S Activity, and Activated Protein C Resistance in Pregnant Women
Authors: Kristoffersen Ann H , Petersen Per H , Røraas Thomas , Sandberg Sverre 
Published: February 2017

Abstract

BACKGROUND
In pregnancy, interpretation of results from coagulation parameters can be difficult because of the procoagulant physiological changes. The aim of this study was to describe the course of 5 coagulation parameters (thrombophilia markers) in healthy pregnancies, and to estimate and compare the within-subject biological variation (CVI) of these parameters in healthy pregnant and nonpregnant women.

METHODS
Blood samples were obtained every 4th week during pregnancy and 3 samples after delivery in 20 healthy women and every 4th week during 40 weeks in 19 healthy nonpregnant women. Protein C (PC), antithrombin (AT), protein S free (PS free), protein S activity (PS activity), and activated protein C resistance (with factor V–depleted plasma) (APCR) were analyzed. Before the calculation of CVI, results were transformed into multiples of the median (MoM) and natural logarithm of MoM (lnMoM) to adjust for the physiological changes during pregnancy.

RESULTS
During pregnancy, PC results showed large variability, AT decreased slightly, and PS free and PS activity decreased significantly. Both activated partial thromboplastin time tests used to calculate APCR decreased, and the APCR ratio was constant. The CVI (lnMoM) in pregnancy were for PC 8.4%, for AT 3.8%, for PS free 11.5%, for PS activity 9.3%, and for APCR 0.5%, and similar to corresponding results in nonpregnant women.

CONCLUSIONS
Transformation of coagulation parameters in healthy pregnancies to lnMoM is a tool to establish a kind of steady state. Although there is a physiological change in PC, AT, and PS free and PS activity during pregnancy, the CVI was comparable with the CVI of nonpregnant women.
Noninvasive Prenatal Screening of Fetal Aneuploidy without Massively Parallel Sequencing
Authors: Xu Chenming , Wang Ting , Liu Chao , Li Hong , Chen Xiaoyan , Zhu Huanhuan , Chen Songchang , Xin Qiuhong , Tao Jing , Huang Liming , Jiang Zhengwen 
Published: February 2017

Abstract

BACKGROUND
Noninvasive prenatal screening (NIPS) using plasma cell-free DNA has gained tremendous popularity in the clinical assessment of fetal aneuploidy. Most, if not all, of these tests rely on complex and expensive massively parallel sequencing (MPS) techniques, hindering the use of NIPS as a common screening procedure.

METHODS
We have developed and optimized an MPS-independent noninvasive genetic test that can rapidly detect fetal aneuploidy at considerably lower costs. We used the high-throughput ligation-dependent probe amplification (HLPA) assay with standard z score statistics to identify the minute copy number change of targeted chromosomal regions. HLPA was modified from multiplex ligation-dependent probe amplification to allow quantification of up to 200 genomic loci in a single multiplex PCR. As a proof of principle, we conducted Down syndrome screening in 1182 women with singleton pregnancies [maternal age (SD): 32.7 (4.6)] using whole-genome sequencing-based NIPS and our method.

RESULTS
Nineteen fetuses with trisomy 21 were detected by both methods and confirmed by karyotyping of amniotic fluid. Overall, our method showed 100.0% sensitivity (19/19) and 99.7% specificity (1076/1079) in trisomy 21 screening, generating a positive predictive value of 86.4% (19/22) and a 7.1% (84/1182) no-call rate.

CONCLUSIONS
Our technique potentially opens new avenues for the development of inexpensive, yet effective, prenatal aneuploidy tests. The simplicity and accuracy of this method make it a good candidate for clinical implementation as a standard screening procedure.
Aufbruch ins Ungewisse. Migration und Integration als Themen theologischer Ethik
Authors: David Philipp 
Published: February 2017

Abstract
This contribution analyses how theological ethics deal with migration and integration as future topics of global relevance. It points out that it is prudent for society, theology and the churches to come to terms with these topics, and also shows their anthropological implications. Migration is considered an existential issue and visible manifestation of human vulnerability. Noting the abundance of motifs of migration in biblical texts, this essay suggests that in view of the social challenges ethics adopt a self-critical and modest attitude which respects individual life histories.
Neutestamentliche Hermeneutik aus alttestamentlicher Sicht. Theologische Anmerkungen zum Entwurf von Ulrich Luz
Authors: Hartenstein Friedhelm 
Published: February 2017

Abstract
Published in 2014, the Theologische Hermeneutik des Neuen Testaments (Theological Hermeneutics of the New Testament) by Ulrich Luz challenges its readers to a theological response through its intentionally personal accountability and its dialogical structure. This essay approaches the discussion from the perspective of the neighboring discipline of Old Testament scholarship. It reconstructs the basic intentions of Luz’s conception and tries to integrate it into the present theological landscape regarding the question of biblical hermeneutics (II./ III.). Afterwards it discusses Luz’s treatment of the Old Testament related to this background and formulates impulses for further discussion of the issue (IV.). It concludes with five theses (»Für eine biblische Hermeneutik der zweiteiligen Bibel«/»For a biblical hermeneutics of the two-partite Bible«) intended to serve the communication about a common subject of the biblical disciplines and Protestant theology as a whole (V.).
Analyzing of relationship between teachers’ individual innovativeness levels and their tpack self-efficacies
Authors: Çoklar Ahmet Naci , Özbek Ayşe 
Published: February 2017

Individual characteristics of people such as approach to technology, knowledge level and perceptions come into prominence. Rogers is classified individuals in five different categories (innovators, early adaptors, early majority, late majority, laggards) in terms of their innovation characteristics and states them as individual innovativeness. Having an individual innovativeness level is a factor which not only may influence people’s skills concerning use of technology but also may influence teachers’ technological integration level in the class. This study aims to determine the effect of teachers’ individual innovativeness level on technological integration process. In line with this purpose, TPACK self-efficacies scale and individual innovativeness scale have been applied to 421 teachers employed in Turkey in 2013-2014 education years. Teachers’ individual innovativeness levels, TPACK skill conditions and predictive power level of individual innovativeness on TPACK skills have been researched. As a result of this research, it has been understood that a great majority of teachers consider themselves as early majority and early adaptors as well as being advanced level in terms of TPACK skills. In addition it has been concluded that there is a positive and important relationship between individual innovativeness and TPACK, while individual innovativeness becomes an important predictor of TPACK skills.