bluuebunny/crossref_metadata_2025_split huggingface dataset:
Existence of Solutions of a New Class of Impulsive Initial Value Problems of Singular Nonlinear Fractional Differential Systems
Authors: Liu Yuji 
Published: November 2016

Abstract:
Sufficient conditions are given for the existence of solutions of impulsive boundary value problems for singular nonlinear fractional differential systems. We allow the nonlinearities

p
(
t
)
f
(
t
,
y
)

$$p(t)f(t,y)$$

and

q
(
t
)
g
(
t
,
x
)

$$q(t)g(t,x)$$

in fractional differential equations to be singular at

t

=

0

$$t\!=\!0$$

. Both

f

$$f$$

and

g

$$g$$

may be super-linear and sub-linear. The analysis relies on some well-known fixed point theorems. The initial value problem discussed may be seen as a generalization of some ecological models. An example is given to illustrate the efficiency of the main theorems. A conclusion section is given at the end of the paper.
Precise Point Positioning Model Using Triple GNSS Constellations: GPS, Galileo and BeiDou
Authors: Afifi Akram , El-Rabbany Ahmed 
Published: November 2016

AbstractThis paper introduces a comparison between dual-frequency precise point positioning (PPP) post-processing model, which combines the observations of three different GNSS constellations, namely GPS, Galileo, and BeiDou and real-time PPP model. A drawback of a single GNSS system such as GPS, however, is the availability of sufficient number of visible satellites in urban areas. Combining GNSS observations offers more visible satellites to users, which in turn is expected to enhance the satellite geometry and the overall positioning solution. However, combining several GNSS observables introduces additional biases, which require rigorous modelling, including the GNSS time offsets and hardware delays. In this paper, a GNSS post-processing PPPP model is developed using ionosphere-free linear combination. The additional biases of the GPS, Galileo, and BeiDou combination are accounted for through the introduction of a new unknown parameter, which is identified as the inter-system bias, in the PPP mathematical model. Natural Resources Canada’s GPSPace PPP software is modified to enable a combined GPS / Galileo / BeiDou PPP solution and to handle the newly inter-system bias. A total of four data sets at four IGS stations are processed to verify the developed PPP model. Precise satellite orbit and clock products from the IGS-MGEX network are used to correct of the GPS, Galileo and BeiDou measurements. For the real-time PPP model the corrections of the satellites orbit and clock are obtained through the international GNSS service (IGS) real-time service (RTS). GPS and Galileo Observations are used for the GNSS RTS-IGS PPP model as the RTS-IGS satellite products are not available for BeiDou satellites. This paper provides the GNSS RTS-IGS PPP model using different satellite clock corrections namely: IGS01, IGC01, IGS01, and IGS03. All PPP models results of convergence time and positioning precision are compared to the traditional GPS-only PPP model. It is shown that combining GPS, Galileo, and BeiDou observations in a PPP model reduces the convergence time by 25 % compared with the GPS-only PPP model.
An Intelligent System for Identifying Influential Words in Real-Estate Classifieds
Authors: Abdallah Sherief 
Published: November 2016

AbstractThis paper focuses on the problem of quantifying how certain words in a text affect, positively or negatively, some numeric signal. These words can lead to important decisions for significant applications such as E-commerce. For example, consider the corpus of real-estate classifieds, which we developed as a case study. Each classified has a description of a real-estate property, along with simple features such as the location and the number of bedrooms. The problem then is to identify which keywords influence the price of the property. Such identification is complicated due to the existence of simple features (numeric and nominal attributes) that also affect the price. In this research, we propose a two-stage regression model to solve this problem. To assess our contribution, we analyze, as a case study, four corpora of real-estate classifieds. The analysis shows that our model predicts the price of a real-estate unit more accurately using the accompanying text, compared to the prediction relying only on simple features. We also demonstrate the capability of our model to annotate (automatically) words that affect the price positively or negatively.
Crystal structure of a P4-bridged (η
5-pentamethyl-cyclopentadienyl)(η
5-adamantylcyclopentadienyl) titanium(III)complex, C50H66P4Ti2
Authors: Oswald Tim , Beermann Thomas , Saak Wolfgang , Beckhaus Rüdiger 
Published: November 2016

Abstract
C50H66P4Ti2, orthorhombic, P21212 (no. 18), a = 14.3799(5) Å, b = 15.4444(6) Å, c = 9.5555(5) Å, V = 2122.17(16) Å3, Z = 2, Rgt(F) = 0.0338, wRref(F2) = 0.0643, T = 153(2) K.
Crystal structure of cis-tetrabromidobis(pyridine-κN)platinum(IV), C10H10Br4N2Pt
Authors: Ha Kwang 
Published: November 2016

Abstract
C10H10Br4N2Pt, monoclinic, P21/c (no. 14), a = 8.0172(4) Å, b = 13.1989(7) Å, c = 13.8836(8) Å, β = 95.995(3)°, V = 1461.10(14) Å3, Z = 4, R
gt(F) = 0.0477, wR
ref(F
2) = 0.1189, T = 223(2) K.
Antibacterial potential of nanocomposite-based materials – a short review
Authors: Karwowska Ewa 
Published: November 2016

AbstractNanotechnology allows for the development of new types of materials containing antimicrobial properties. Nanocomposite-based products are increasingly applied in medicine, industry and everyday life. Antibacterial features allow the use of nanoproducts in filters for water and air purification, textiles, food packages, medical materials and devices, ceramics, glass, plastics, paints, cosmetics and personal care products. Numerous studies concern the synthesis of novel antimicrobial nanoproducts as well as modification of already existing nanomaterials in order to supply them with antibacterial activity. However, some problems related to the potential emission of nanocomponents into the environment can appear and should be considered.
Membrane mimetics for solution NMR studies of membrane proteins
Authors: Mineev Konstantin S. , Nadezhdin Kirill D. 
Published: November 2016

AbstractMembrane proteins are one of the most challenging and attractive objects in modern structural biology, as they are targets for the majority of medicines. However, studies of membrane proteins are hindered by several obstacles, including their low ability to crystallize, highly dynamic behavior of some of their domains, and need for membrane-like environment. Although solution nuclear magnetic resonance (NMR) is a very powerful technique of structural biology in terms of the amount of provided data, it imposes several limitations on the object under investigation, with the main constraint being related to the size of the object. For this reason, the membrane mimetic has to form particles of small size and simultaneously to properly simulate the bilayer membrane to be applicable for solution NMR spectroscopy. Here we review the recent advances in the field of membrane mimetics for solution NMR studies, discuss the advantages and drawbacks of specific membrane-like environments, and formulate the criteria for the selection of proper environment for a particular membrane protein or domain.
A multilevel governance framework for regulation of nanomedicine in India
Authors: Bhatia Pooja , Chugh Archana 
Published: November 2016

AbstractNanomedicine is a novel and challenging field in terms of its governance. It is gradually emerging that the existing regulatory regimes may not be able to accommodate the requirements of nanomedicine without amendments or supportive measures. Further, its multidisciplinary essence poses challenges and indicates a need for an adaptive regulatory framework for governance as well as promotion of innovation system. The best strategy to govern nanomedicine remains highly debatable across the globe. Although, major challenges posed by nanomedicine are universal, some of them are specific to each country, hence, making a jurisdiction-based framework essential to address unique needs of a nation. In India, a clear framework for the regulation of nanomedicine is lacking, as this governance gap has been realized through various studies. Keeping this in view, the authors propose a multi-level national governance system for regulation of nanomedicine in India based on four principles. The hierarchical governance model proposed involves regulatory space, policy regime, sites of governance and lifecycle of nanomedicine. The proposed system is inclusive of its various stakeholders. The system can play a significant role in sustainable growth of nanomedicine in India.
Virtual modelling of novel applicator prototypes for cervical cancer brachytherapy
Authors: Petric Primoz , Hudej Robert , Al-Hammadi Noora , Segedin Barbara 
Published: November 2016

AbstractBackgroundStandard applicators for cervical cancer Brachytherapy (BT) do not always achieve acceptable balance between target volume and normal tissue irradiation. We aimed to develop an innovative method of Target-volume Density Mapping (TDM) for modelling of novel applicator prototypes with optimal coverage characteristics. Patients and methods. Development of Contour-Analysis Tool 2 (CAT-2) software for TDM generation was the core priority of our task group. Main requests regarding software functionalities were formulated and guided the coding process. Software validation and accuracy check was performed using phantom objects. Concepts and terms for standardized workflow of TDM post-processing and applicator development were introduced.ResultsCAT-2 enables applicator-based co-registration of Digital Imaging and Communications in Medicine (DICOM) structures from a sample of cases, generating a TDM with pooled contours in applicator-eye-view. Each TDM voxel is assigned a value, corresponding to the number of target contours encompassing that voxel. Values are converted to grey levels and transformed to DICOM image, which is transported to the treatment planning system. Iso-density contours (IDC) are generated as lines, connecting voxels with same grey levels. Residual Volume at Risk (RVR) is created for each IDC as potential volume that could contain organs at risk. Finally, standard and prototype applicators are applied on the TDM and virtual dose planning is performed. Dose volume histogram (DVH) parameters are recorded for individual IDC and RVR delineations and characteristic curves generated. Optimal applicator configuration is determined in an iterative manner based on comparison of characteristic curves, virtual implant complexities and isodose distributions.ConclusionsUsing the TDM approach, virtual applicator prototypes capable of conformal coverage of any target volume, can be modelled. Further systematic assessment, including studies on clinical feasibility, safety and effectiveness are needed before routine use of novel prototypes can be considered.
Endovascular treatment of unruptured aneurysms of cavernous and ophthalmic segment of internal carotid artery with flow diverter device Pipeline
Authors: Jevsek Marko , Mounayer Charbel , Seruga Tomaz 
Published: November 2016

Abstract

Background
Intra-arterial treatment of aneurysms by redirecting blood flow is a newer method. The redirection is based on a significantly more densely braided wire stent. The stent wall keeps the blood in the lumen of the stent and slows down the turbulent flow in the aneurysms. Stagnation of blood in the aneurysm sac leads to the formation of thrombus and subsequent exclusion of the aneurysm from the circulation. The aim of the study was to evaluate flow diverter device Pipeline for broad neck and giant aneurysm treatment.

Methods
Fifteen patients with discovered aneurysm of the internal carotid artery were treated between November 2010 and February 2014. The majority of aneurysms of the internal carotid artery were located intradural at the ophthalmic part of the artery. The patients were treated using a flow diverter device Pipeline, which was placed over the aneurysm neck. Treatment success was assessed clinically and angiographically using O’Kelly Marotta scale.

Results
Control angiography immediately after the release of the stent showed stagnation of the blood flow in the aneurysm sac. In none of the patients procedural and periprocedural complications were observed. 6 months after the procedure, control CT or MR angiography showed in almost all cases exclusion of the aneurysm from the circulation and normal blood flow in the treated artery. Neurological status six months after the procedure was normal in all patients.

Conclusions
Treatment of aneurysms with flow diverter Pipeline device is a safe and significantly less time consuming method in comparison with standard techniques. This new method is a promising approach in treatment of broad neck aneurysms.
Respiratory toxicity of Fe3O4 nanoparticles: experimental study
Authors: Hurbankova Marta , Volkovova Katarina , Hraskova Dominika , Wimmerova Sona , Moricova Stefania 
Published: November 2016

Abstract

Introduction:
In the medical field, nanoparticles (NP) Fe3O4 are currently considered to be a relatively inert carrier for therapeutic and diagnostic pharmaceuticals, and they are also presumed for intravenous (i.v.) administration. Because they have nano dimensions, they probably can penetrate through various membranes and pass from the bloodstream to other organs in the body (Borm P, Muller-Schulte D. Nanoparticles in medicine, 2007, Chapter 21, pp. 387–413, Particle Toxicology, ed. Donaldson K, Borm P, Taylor & Francis Group, USA, 434 p., ISBN 0-8493-5092-1). Therefore, in our experiment, we have examined the impact of a NP Fe3O4 instilled i.v. (to a tail vein of an animal) on the select parameters of bronchoalveolar lavage (BAL). The aim of our study was to determine whether the NP investigated by us, pass through the vascular system to the respiratory tract, and if so, how they affect the selected inflammatory and cytotoxic parameters of BAL.

Materials and methods:
Wistar rats were intravenously given a suspension of Fe3O4 and after time intervals of 1, 7, 14 and 28 days, the animals were sacrificed, BAL was performed and selected inflammatory and cytotoxic BAL parameters were examined.

Conclusion:
Based on the results obtained by us, Fe3O4 NP exposure, compared to the control, induced inflammatory response, the cytotoxic damage and respiratory toxicity. The results further show that Fe3O4 NP, 28 days after i.v. instillation, were eliminated from the respiratory tract by defense mechanisms.
Air exchange rates and alternative vapor entry pathways to inform vapor intrusion exposure risk assessments
Authors: Reichman Rivka , Roghani Mohammadyousef , Willett Evan J. , Shirazi Elham , Pennell Kelly G. 
Published: November 2016

Abstract
Vapor intrusion (VI) is a term used to describe indoor air (IA) contamination that occurs due to the migration of chemical vapors in the soil and groundwater. The overall vapor transport process depends on several factors such as contaminant source characteristics, subsurface conditions, building characteristics, and general site conditions. However, the classic VI conceptual model does not adequately account for the physics of airflow around and inside a building and does not account for chemical emissions from alternative “preferential” pathways (e.g. sewers and other utility connections) into IA spaces. This mini-review provides information about recent research related to building air exchange rates (AERs) and alternative pathways to improve the accuracy of VI exposure risk assessment practices. First, results from a recently published AER study for residential homes across the United States (US) are presented and compared to AERs recommended by the US Environmental Protection Agency (USEPA). The comparison shows considerable differences in AERs when season, location, building age, and other factors are considered. These differences could directly impact VI assessments by influencing IA concentration measurements. Second, a conceptual model for sewer gas entry into buildings is presented and a summary of published field studies is reported. The results of the field studies suggest that alternative pathways for vapors to enter indoor spaces warrant consideration. Ultimately, the information presented in this mini-review can be incorporated into a multiple-lines-of-evidence approach for assessing site-specific VI exposure risks.
Emerging roles of xenobiotic detoxification enzymes in metabolic diseases
Authors: Petriello Michael C. , Hoffman Jessie B. , Morris Andrew J. , Hennig Bernhard 
Published: November 2016

AbstractMammalian systems have developed extensive molecular mechanisms to protect against the toxicity of many exogenous xenobiotic compounds. Interestingly, many detoxification enzymes, including cytochrome P450s and flavin-containing monooxygenases, and their associated transcriptional activators [e.g. the aryl hydrocarbon receptor (AhR)], have now been shown to have endogenous roles in normal physiology and the pathology of metabolic diseases. This mini-review will focus on two such instances: the role of flavin-containing monooxygenase 3 (FMO3) in the formation of the cardiometabolic disease biomarker trimethylamine-N-oxide (TMAO) and the role of AhR as a sensor of endogenous ligands such as those generated by the gut microbiota. Understanding the roles of xenobiotic sensing pathways in endogenous metabolism will undoubtedly lead to a better understanding of how exposure to environmental pollutants can perturb these physiological processes.
Effect of alkali treatment on hair fiber as reinforcement of HDPE composites: mechanical properties and water absorption behavior
Authors: Srivastava Prashant , Sinha Shishir 
Published: November 2016

Abstract
This research work investigated the effect of fiber loading and alkali treatment on hair fiber (HF)-reinforced high-density polyethylene (HDPE) composites in terms of mechanical properties and water absorption behavior. The mechanical stability of the composite material was studied by Universal Testing Machine. The alkali treatment of HF-reinforced HDPE composites was responsible for the investigation of the mechanical and water absorption properties. Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) analysis were also done for the study of the reinforced polymer composites. The results of the SEM analysis were very helpful for the study of the morphology of the fiber-matrix interface for better/optimum mechanical properties.
Three variants of novel Co(II) complex with NSAID mefenamic acid and N,N′-donor ligand neocuproine
Authors: Smolková Romana , Zeleňák Vladimír , Smolko Lukáš , Dušek Michal 
Published: November 2016

Abstract
Three variants of novel cobalt(II) complex with deprotonated mefenamic acid (mef) and N,N′-donor ligand neocuproine (neo) are described, namely; two differently colored and shaped crystal polymorphs of complex [Co(mef)2(neo)] (1a and 1b) and a pyridine solvate [Co(mef)2(neo)]·py (2). The complexes have been characterized by infrared and UV-VIS spectroscopy, elemental analysis and single-crystal X-ray structure analysis. Although the complexes 1a, 1b and 2 crystallize in different crystal systems and space groups and differ in shapes of coordination polyhedra, the crystal structures of all three complexes contain analogous neutral units with Co(II) atom hexacoordinated by two chelate bonded mefenamato ligands and one chelate bonded neocuproine ligand, yielding CoN2O4 chromophore. The main structural difference between 1a, 1b and 2 is the conformation of the coordinated mef ligands, which affects the crystal packing of the complexes.
EVALUASI DAYA TAHAN IKAN MAS HASIL SELEKSI BERDASARKAN MARKA MOLEKULER MHC-II TERHADAP INFEKSI KOI HERPES VIRUS
Authors: Hayuningtyas Erma Primanita , Syahputra Khairul , Ariyanto Didik 
Published: November 2016

Balai Penelitian Pemuliaan Ikan telah menghasilkan populasi ikan mas tahan Koi Herpes Virus (KHV) generasi pertama (F-1) melalui program selective breeding. Seleksi dilakukan dengan metode walk-back selection menggunakan marka gen MHC-II spesifik pada lokus Cyca-Cyca-DAB 1*05. Penelitian ini bertujuan untukmengevaluasi daya tahan benih ikan mas F-1 terseleksi terhadap infeksi KHV melalui uji tantang. Sebagai pembanding, digunakan ikan mas populasi benih F-1 non-seleksi dan populasi benih ikan mas dari unit pembenihan rakyat (UPR). Ikan uji berupa benih ikan mas Rajadanu berumur dua bulan dengan bobot ratarata 5,5±0,5 g. Jumlah benih pada masing-masing wadah perlakuan sebanyak 30 ekor dengan tiga kali pengulangan. Wadah pengujian berupa akuarium berukuran 40 cm x 60 cm x 40 cm dengan kepadatan 1 ekor/L. Parameter yang diamati adalah sintasan, deteksi KHV, analisis ekspresi gen MHC-II, dan gambaran darah ikan. Hasil penelitian menunjukkan bahwa populasi benih F-1 terseleksi memiliki daya tahan lebih baik dengan sintasan 93,33% dibandingkan populasi benih F-1 non-seleksi sebesar 85,55% dan populasi benih dari UPR sebesar 81,11%. Daya tahan yang tinggi pada populasi benih F-1 terseleksi didukung oleh hasil deteksi KHV yang negatif dan ersentase jumlah limfosit yang lebih tinggi sebesar 91,67%; serta rendahnya persentase monosit dan heterofil, selain itu, tidak adanya eosinofil dan basofil. Ekspresi gen MHC-II terdeteksi pada berbagai organ, ekspresi tertinggi ditemukan pada organ limpa.
PENINGKATAN KINERJA REPRODUKSI, KUALITAS TELUR, DAN LARVA MELALUI SUPLEMENTASI Spirulina DIKOMBINASI DENGAN INJEKSI OOCYTE DEVELOPER PADA INDUK IKAN LELE (Clarias sp.) BETINA
Authors: Nainggolan Armen , Sudrajat Agus Oman , Utomo Nur Bambang Priyo , Harris Enang 
Published: November 2016

Penelitian ini dilakukan untuk mempercepat maturasi, meningkatkan kualitas telur, dan kuantitas larva ikan lele (Clarias sp.) melalui pemberian kombinasi suplementasi Spirulina pada pakan dan penyuntikan Oocyte developer (Oodev). Perlakuan yang diberikan terdiri atas: pakan A1: Spirulina 0% dengan Oodev 0 IU; pakan A2: Spirulina 0% dengan Oodev 15 IU; pakan B1: Spirulina 1% dengan Oodev 0 IU; pakan B2: Spirulina 1% dengan Oodev 15 IU; pakan C1: Spirulina 2% dengan Oodev 0 IU; pakan C2: Spirulina 2% dengan Oodev 15 IU; pakan D1: Spirulina 3% dengan Oodev 0 IU; pakan D2: Spirulina 3% dengan Oodev 15 IU. Selama 30 hari pemeliharaan, induk ikan diberi pakan perlakuan dengan feeding rate sebesar 3% dari bobot badannya dengan frekuensi pemberian dua kali sehari pada pukul 8.00 dan 17.00 WIB. Parameter yang diamati adalah Gonado Somatic Index (GSI), konsentrasi estradiol-17, konsentrasi protein vitelogenin, fekunditas dan viabilitas larva. Hasil penelitian menunjukkan bahwa nilai GSI tertinggi selama penelitian diperoleh pada perlakuan D2 (9,94%) dibandingkan dengan perlakuan yang lain. Hasil analisis estradiol-17 dan vitelogenin pada perlakuan D2 mengindikasikan kematangan gonad lebih cepat dibandingkan dengan perlakuan yang lain. Selanjutnya fekunditas tertinggi dihasilkan pada perlakuan D2 sebesar 81.953±164 butir dengan derajat penetasan 90,70±0,24 dan sintasan larva tertinggi (umur empat hari) yakni sebesar 92,94±0,064. Dengan demikian, suplementasi Spirulina dengan dosis 3% pada pakan yang dikombinasikan dengan Oodev dosis 15 IU adalah yang terbaik untuk mempercepat kematangan gonad induk dan menstimulasi kinerja reproduksi terutama pada perkembangan gonad, kualitas telur, larva, dan ketahanan hidup larva.