bluuebunny/crossref_metadata_2025_split huggingface dataset:
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder
Authors: Ravindran Arun V. , Balneaves Lynda G. , Faulkner Guy , Ortiz Abigail , McIntosh Diane , Morehouse Rachel L. , Ravindran Lakshmi , Yatham Lakshmi N. , Kennedy Sidney H. , Lam Raymond W. , MacQueen Glenda M. , Milev Roumen V. , Parikh Sagar V. ,   the CANMAT Depression Work Group
Published: August 2016

Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted a revision of the 2009 guidelines by updating the evidence and recommendations. The scope of the 2016 guidelines remains the management of major depressive disorder (MDD) in adults, with a target audience of psychiatrists and other mental health professionals. Methods: Using the question-answer format, we conducted a systematic literature search focusing on systematic reviews and meta-analyses. Evidence was graded using CANMAT-defined criteria for level of evidence. Recommendations for lines of treatment were based on the quality of evidence and clinical expert consensus. “Complementary and Alternative Medicine Treatments” is the fifth of six sections of the 2016 guidelines. Results: Evidence-informed responses were developed for 12 questions for 2 broad categories of complementary and alternative medicine (CAM) interventions: 1) physical and meditative treatments (light therapy, sleep deprivation, exercise, yoga, and acupuncture) and 2) natural health products (St. John’s wort, omega-3 fatty acids; S-adenosyl-L-methionine [SAM-e], dehydroepiandrosterone, folate, Crocus sativus, and others). Recommendations were based on available data on efficacy, tolerability, and safety. Conclusions: For MDD of mild to moderate severity, exercise, light therapy, St. John’s wort, omega-3 fatty acids, SAM-e, and yoga are recommended as first- or second-line treatments. Adjunctive exercise and adjunctive St. John’s wort are second-line recommendations for moderate to severe MDD. Other physical treatments and natural health products have less evidence but may be considered as third-line treatments. CAM treatments are generally well tolerated. Caveats include methodological limitations of studies and paucity of data on long-term outcomes and drug interactions.
Weight-Related Goal Setting in a Telephone-Based Preventive Health-Coaching Program: Demonstration of Effectiveness
Authors: O’Hara Blythe J. , Gale Joanne , McGill Bronwyn , Bauman Adrian , Hebden Lana , Allman-Farinelli Margaret , Maxwell Michelle , Phongsavan Philayrath 
Published: August 2016

Purpose: This study investigated whether participants in a 6-month telephone-based coaching program, who set physical activity, nutrition, and weight loss goals had better outcomes in these domains. Design: Quasi-experimental design. Setting: The Australian Get Healthy Information and Coaching Service (GHS), a free population-wide telephone health-coaching service that includes goal setting as a key component of its coaching program. Participants: Consenting GHS coaching participants who had completed coaching between February 2009 and December 2012 (n = 4108). Measures: At baseline, participants select a goal for the coaching program, and sociodemographic variables are collected. Self-reported weight, height, waist circumference, physical activity, and nutrition-related behaviors are assessed at baseline and 6 months. Analysis: Descriptive analysis was performed on key sociodemographic variables, and the relationship between goal type and change in health outcomes was assessed using a series of linear mixed models that modeled change from baseline to 6 months. Results: Participants who set goals in relation to weight management and physical activity achieved better results in these areas than those who set alternate goals, losing more than those who set alternate goals (1.5 kg and 0.9 cm in waist circumference) and increasing walking per week (40 minutes), respectively. There was no difference in food-related outcomes for those that set nutrition-related goals. Conclusion: Goal setting for weight management and increasing physical activity in the overweight and obese population, undertaken in a telephone-based coaching program, can be effective.
Modification of cerebral vascular anatomy induced by Leo stent placement depending on the site of stenting: A series of 102 cases
Authors: Chau Y , Mondot L , Sachet M , Gaudart J , Fontaine D , Lonjon M , Sédat J 
Published: August 2016

Background and purpose Recent studies demonstrated the capacity of stents to modify cerebral vascular anatomy. This study evaluates arterial anatomy deformation after Leo stent placement according to the stenting site and the impact on the immediate postoperative and six-month degree of aneurysmal occlusion. Materials and methods A total of 102 stents were placed against the neck of aneurysms situated in the anterior cerebral circulation. Aneurysms were classified into two groups: The first was called the distal group ( n = 62) and comprised aneurysms situated in the middle cerebral and anterior communicating arteries and the second was called the proximal group ( n = 40) and comprised aneurysms in other sites. The stented arterial segment was classified as deformed or non-deformed by blinded review and superimposition of anonymised films before and after stenting. The degree of occlusion was determined immediately postoperatively and at six months. Results Significantly, anatomical deformity was observed in the distal group compared to the proximal group (85% vs 28%). No significant difference was observed between the two groups in terms of postoperative degree of occlusion. At six months, a significant difference was observed between the two groups: three recurrences in the distal group vs 10 recurrences in the proximal group. Two (3%) recurrences were observed in the deformed group vs 11 (31%) recurrences in the non-deformed group. Conclusions Arterial deformity induced by stenting is even more marked for distal aneurysms. The recurrence rate is smaller when the stent placement results in an arterial anatomical change. The percentage of recurrence is lower when anatomy was amended by stent implantation.
Variable exposure time imaging for obtaining unblurred HDR images
Authors: Uda Saori , Sakaue Fumihiko , Sato Jun 
Published: August 2016

Abstract
In this paper, we propose a new camera and a new imaging technique for obtaining unblurred high-dynamic-range (HDR) images. In this camera, we achieve pixelwise control of exposure parameters by using a liquid crystal on silicon. In particular, we can control not only the amount of exposure but also the exposure time pixel by pixel. We call the imaging as variable exposure time imaging. By using the variable exposure time imaging, we can suppress motion blur of bright regions. In addition, we propose a motion blur recovering method from variable exposure time images for obtaining more distinct images including darker regions. Experimental results show our method can take a clear HDR image even if the target object moves in HDR scene.
Loss ofvhlin the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma
Authors: Noonan Haley R. , Metelo Ana M. , Kamei Caramai N. , Peterson Randall T. , Drummond Iain A. , Iliopoulos Othon 
Published: August 2016

ABSTRACTPatients with von Hippel–Lindau (VHL) disease harbor a germline mutation in the VHL gene leading to the development of several tumor types including clear cell renal cell carcinoma (ccRCC). In addition, the VHL gene is inactivated in over 90% of sporadic ccRCC cases. ‘Clear cell’ tumors contain large, proliferating cells with ‘clear cytoplasm’, and a reduced number of cilia. VHL inactivation leads to the stabilization of hypoxia inducible factors 1a and 2a [HIF1a and HIF2a (HIF2a is also known as EPAS1)] with consequent up-regulation of specific target genes involved in cell proliferation, angiogenesis and erythropoiesis. A zebrafish model with a homozygous inactivation in the VHL gene (vhl−/−) recapitulates several aspects of the human disease, including development of highly vascular lesions in the brain and the retina and erythrocytosis. Here, we characterize for the first time the epithelial abnormalities present in the kidney of the vhl−/− zebrafish larvae as a first step in building a model of ccRCC in zebrafish. Our data show that the vhl−/− zebrafish kidney is characterized by an increased tubule diameter, disorganized cilia, the dramatic formation of cytoplasmic lipid vesicles, glycogen accumulation, aberrant cell proliferation and abnormal apoptosis. This phenotype of the vhl−/− pronephros is reminiscent of clear cell histology, indicating that the vhl−/− mutant zebrafish might serve as a model of early stage RCC. Treatment of vhl−/− zebrafish embryos with a small-molecule HIF2a inhibitor rescued the pronephric abnormalities, underscoring the value of the zebrafish model in drug discovery for treatment of VHL disease and ccRCC.
Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity
Authors: Brehme Marc , Voisine Cindy 
Published: August 2016

ABSTRACTChaperones and co-chaperones enable protein folding and degradation, safeguarding the proteome against proteotoxic stress. Chaperones display dynamic responses to exogenous and endogenous stressors and thus constitute a key component of the proteostasis network (PN), an intricately regulated network of quality control and repair pathways that cooperate to maintain cellular proteostasis. It has been hypothesized that aging leads to chronic stress on the proteome and that this could underlie many age-associated diseases such as neurodegeneration. Understanding the dynamics of chaperone function during aging and disease-related proteotoxic stress could reveal specific chaperone systems that fail to respond to protein misfolding. Through the use of suppressor and enhancer screens, key chaperones crucial for proteostasis maintenance have been identified in model organisms that express misfolded disease-related proteins. This review provides a literature-based analysis of these genetic studies and highlights prominent chaperone modifiers of proteotoxicity, which include the HSP70-HSP40 machine and small HSPs. Taken together, these studies in model systems can inform strategies for therapeutic regulation of chaperone functionality, to manage aging-related proteotoxic stress and to delay the onset of neurodegenerative diseases.
Thermal Defects of Avionic Turbojet Engines
Authors: Szczepankowski Andrzej , Szymczak Janusz 
Published: August 2016

AbstractThe paper analyzes the most frequent reasons associated with operation of avionic turbojet engines (ATE) and leading to initiation of thermal defects affecting turbine units. These reasons are illustrated with examples of gradual deteriorations revealed on surfaces of turbine parts and subassemblies and defected during endoscopic examinations of propelling drives. Attention is paid to various design and technological improvements that are implemented to counteract such deteriorations. The analysis is focused on mistakes that are committed during operation, repairs or manufacturing of avionic turbojet engines and that may affect safety of aircraft operations.
On an Extension Problem for Contractive Block Hankel Operator Matrices
Authors: Fritzsche Bernd , Hirstein Bernd , Lorenz Jürgen 
Published: August 2016

Abstract
The paper deals with an operator extension problem for contractive block Hankel operators which arose in the context of the operator version of the classical Nehari interpolation problem. V.M. Adamjan, D.Z. Arov, and M.G. Krein [5] obtained that the solution set of this operator extension problem is an operator ball. Hereby, they constructed the parameters of this operator ball via a regularization procedure using the corresponding expressions of the first studied nondegenerate case. The main aim of this paper is to derive more explicit formulas for the parameters of this operator ball. Hereby we use Moore-Penrose inverses of bounded linear operators in Hilbert space.
Borsuk’s antipodal fixed points theorems for compact or condensing set-valued maps
Authors: Altwaijry Najla , Chebbi Souhail , Hammami Hakim , Gourdel Pascal 
Published: August 2016

Abstract
We give a generalized version of the well-known Borsuk’s antipodal fixed point theorem for a large class of antipodally approachable condensing or compact set-valued maps defined on closed subsets of locally convex topological vector spaces.
These results contain corresponding results obtained in the literature for compact set-valued maps with convex values.
Association of Single Nucleotide Polymorphisms in the FABP4 Gene with Carcass Characteristics and Meat Quality in Holstein Bulls
Authors: Ardicli Sena , Samli Hale , Alpay Fazli , Dincel Deniz , Soyudal Bahadir , Balci Faruk 
Published: August 2016

Abstract
The aim of this study was to characterize the bovine fatty acid binding protein (FABP4) gene 3691G>A and 2834C>G polymorphisms and to evaluate interaction effects on the live weight, carcass characteristics and meat quality of Holstein bulls in the South Marmara region of Turkey. A total of 400 Holstein bulls grown on a private farm and slaughtered at 14-21 months of age, were randomly selected for use in this study. Initially, genotyping was performed by PCR-RFLP method and statistical analysis was carried out using least square methods of the GLM procedure. A SNP located in intron 1 (2834C>G) was associated with desirable increases in live weight, hot carcass weight and chilled carcass weight, and a SNP located in exon 3 (3691G>A) was associated with significant increases in marbling scores and first compressive stress point of the longissimus
dorsi muscle (P<0.05). The interaction analysis of the 3691G>A and the 2834C>G polymorphisms revealed significant effects for hot carcass weight, chilled carcass weight and backfat thickness (P<0.05). There were no significant associations between the SNPs and carcass measurements. Results indicated that the FABP4 3691G>A and 2834C>G polymorphisms and the 3691G>A and 2834C>G interactions can be used as selection parameters in breeding programmes to improve meat yield and carcass characteristics.
Embryo quality predictive models based on cumulus cells gene expression
Authors: Devjak R , Burnik Papler T , Verdenik I , Fon Tacer K , Vrtačnik Bokal E 
Published: August 2016

Abstract
Since the introduction of in vitro fertilization (IVF) in clinical practice of infertility treatment, the indicators for high quality embryos were investigated. Cumulus cells (CC) have a specific gene expression profile according to the developmental potential of the oocyte they are surrounding, and therefore, specific gene expression could be used as a biomarker. The aim of our study was to combine more than one biomarker to observe improvement in prediction value of embryo development. In this study, 58 CC samples from 17 IVF patients were analyzed. This study was approved by the Republic of Slovenia National Medical Ethics Committee. Gene expression analysis [quantitative real time polymerase chain reaction (qPCR)] for five genes, analyzed according to embryo quality level, was performed. Two prediction models were tested for embryo quality prediction: a binary logistic and a decision tree model. As the main outcome, gene expression levels for five genes were taken and the area under the curve (AUC) for two prediction models were calculated. Among tested genes, AMHR2 and LIF showed significant expression difference between high quality and low quality embryos. These two genes were used for the construction of two prediction models: the binary logistic model yielded an AUC of 0.72 ± 0.08 and the decision tree model yielded an AUC of 0.73 ± 0.03. Two different prediction models yielded similar predictive power to differentiate high and low quality embryos. In terms of eventual clinical decision making, the decision tree model resulted in easy-to-interpret rules that are highly applicable in clinical practice.
T-lymphoblastic leukemia/lymphoma in macedonian patients with Nijmegen breakage syndrome
Authors: Kocheva SA , Martinova K , Antevska-Trajkova Z , Coneska-Jovanova B , Eftimov A , Dimovski AJ 
Published: August 2016

Abstract
Nijmegen breakage syndrome (NBS) is a rare autosomal recessive chromosomal instability disorder characterized by microcephaly, immunodeficiency, radiosensitivity and a very high predisposition to malignancy. The gene responsible for the disease, NBS1, is located on chromosome 8q21 and encodes a protein called nibrin. After identification of the gene, a truncating 5 bp deletion, 657-661delACAAA, was identified as the disease-causing mutation in patients with the NBS. In this report, we describe two patients with NBS and T-lymphoblastic leukemia/lymphoma in a Macedonian family. To the best of our knowledge, this is the first family with NBS reported from Macedonia. Both children presented with microcephaly, syndactyly and the development of T cell lymphoblastic lekemia/lymphoma at the age of 7 and 10 years, respectively. The molecular analysis of NBS1 genes in our patients showed homozygosity for the 657del5 mutation in the NBS1 gene. The parents were heterozygotes for the 657del5 mutation and they had no knowledge of a consanguineous relationship. The first child was treated with the International Berlin-Frankfurt-Münster (BFM)-Non Hodgkin lymphoma (NHL) protocol and achieved a complete remission that lasted for 21 months. Subsequently, he developed a medullar relapse with hyperleukocytosis and died due to lethal central nervous system (CNS) complications. The second child was treated according to the International Collaborative Treatment Protocol for Children and Adolescents with Acute Lymphoblastic Leukemia 2009 (AIOP-BFM ALL 2009) protocol. Unfortunately, remission was not achieved.
In vivo degradation of binary magnesium alloys – a long-term study
Authors: Myrissa Anastasia , Martinelli Elisabeth , Szakács Gábor , Berger Leopold , Eichler Johannes , Fischerauer Stefan F. , Kleinhans Claudia , Hort Norbert , Schäfer Ute , Weinberg Annelie M. 
Published: August 2016

AbstractBioresorbable magnesium materials are widely investigated because of their promising properties as orthopedic devices. Pure magnesium (99.99%) and two binary magnesium alloys (Mg2Ag and Mg10Gd) were used to investigate the degradation behavior, the bone adherence and bone-implant interface mechanics of these materials in growing Sprague-Dawley
Comparison of Beam-Forming and Relaying in Sparse Sensor Networks
Authors: Mikuláš Krebs 
Published: August 2016

Abstract
This study focuses on the differences in power consumption between beam-forming and relaying data transmission methods in a sparse wireless ad-hoc network. These two methods are observed for the same parameters using an identical network topology in a simulation programme that was developed as a part of this study.
This paper introduces the reader the background of sensor networks and exposes the aims of this study and methods used to simulate these networks. Finally, the results of a simulation are analysed and the two methods are compared, followed by the conclusion of the study and the project itself.
Synthesis and properties of well-defined carbazole-containing fluorescent star polymers of different arms
Authors: Mao Tengfei , Gou Yanzi , Wang Jun , Wang Hao 
Published: August 2016

Abstract
A series of fluorescent carbazole-containing star polymers with different arms were successfully synthesized using 9-(4-vinylbenzyl)9H-carbazole (VBCz) as monomer and multifunctional bromide as initiators via atom transfer radical polymerization (ATRP). The effect of the poly(9-(4-vinylbenzyl)-9H-carbazole) (PVBCz) star polymer architecture on their optical and electrochemical properties was investigated. All of the PVBCz star polymers absorbed light in the range of 280–360 nm both in solution and as polymer films. Meanwhile, the star polymers exhibited maximum fluorescent emission at 350 nm in solution, while at 406 nm as films. Moreover, the star polymers with different arm numbers showed different photoluminescence quantum efficiency and highest and lowest occupied molecular orbital (HOMO, LOMO, respectively) energy levels. It is proved that the PVBCz star polymers exhibited different photoelectronic properties by varying the molecular architectures.
The effect of the biostimulator Goteo on the rooting of ninebark stem cuttings
Authors: Pacholczak Andrzej , Nowakowska Karolina , Mika Natalia , Borkowska Monika 
Published: August 2016

Abstract
As a consequence of restrictions on the use of preparations containing synthetic auxins in nursery production, there is a necessity to replace them with more environmentally friendly biopreparations efficiently stimulating plant growth. The aim of the presented experiment was to compare the effects of the synthetic auxin indole-3-butyric acid (IBA) and the biostimulator Goteo on the rooting of ninebark stem cuttings (Physocarpus opulifolius ‘Dart’s Gold’ and ‘Red Baron’) and to get some insight into the latter’s mechanisms of action in plants. Applications of the biostimulator Goteo produced comparable or slightly weaker effects compared to the treatments with IBA. Goteo stimulated elongation in new growth of cuttings when applied in watering or two-fold spraying methods. Application of the biostimulator resulted in increased levels of chlorophyll, soluble sugars and indole derivatives, while the contents of free amino acids and polyphenolic acids decreased. The above results indicate that, if necessary, Goteo may replace the synthetic auxin IBA in the propagation of ninebark in the future.
Comparison of the ability of mammalian eEF1A1 and its oncogenic variant eEF1A2 to interact with actin and calmodulin
Authors: Novosylna Oleksandra , Doyle Annette , Vlasenko Dmytro , Murphy Mark , Negrutskii Boris , El’skaya Anna 
Published: August 2016

AbstractThe question as to why a protein exerts oncogenic properties is answered mainly by well-established ideas that these proteins interfere with cellular signaling pathways. However, the knowledge about structural and functional peculiarities of the oncoproteins causing these effects is far from comprehensive. The 97.5% homologous tissue-specific A1 and A2 isoforms of mammalian translation elongation factor eEF1A represent an interesting model to study a difference between protein variants of a family that differ in oncogenic potential. We propose that the different oncogenic impact of A1 and A2 might be explained by differences in their ability to communicate with their respective cellular partners. Here we probed this hypothesis by studying the interaction of eEF1A with two known partners – calmodulin and actin. Indeed, an inability of the A2 isoform to interact with calmodulin is shown, while calmodulin is capable of binding A1 and interferes with its tRNA-binding and actin-bundling activitiesin vitro. Both A1 and A2 variants revealed actin-bundling activity; however, the form of bundles formed in the presence of A1 or A2 was distinctly different. Thus, a potential inability of A2 to be controlled by Ca2+-mediated regulatory systems is revealed.