bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noun-modifying clause constructions in Ainu
Authors: Bugaeva Anna 
Published: February 2017

Abstract
The Ainu (Southern Hokkaido) relative clause construction is built on the model of the nominal attributive construction, while the noun-complement construction is based on that of the nominal possessive construction in which the head is marked with a possessive suffix. Also, relative and noun-complement clauses behave differently with regard to island violation constraints: only the latter allow such violations. However, there is a small number of noun-complement clauses without possessive marking on the perception/relational head noun, which makes them look like relative clauses; these are the so-called emergent GNMCCs. I suggest that these head nouns appear in non-possessive form in order to dissociate themselves from the few homonymous possessive heads which are grammaticalized as modal/evidential markers in the relevant constructions.
Adsorption of Pb(II) ion from aqueous solution onto Chitosan/silica/polyethylene glycol (Ch/Si/P) composites membrane
Authors: Mahatmanti F W , Rengga W D P , Kusumastuti E , Nuryono  
Published: February 2017

Abstract
In this research, chitosan/silica/polyethylene glycol (Ch/Si/P) composites membrane was studied for selective adsorbent of Pb(II) from aqueous solution. This study started by preparation of Ch/Si/P composites membrane. The structure and surface morphology of Ch/Si/P composites membrane was characterized by X-ray diffraction (XRD), Fourier Transform Infra Red (FTIR) spectroscopy, and Scanning Electron Microscopy (SEM). Batch adsorption experiments were conducted with various contact time and Pb(II) concentrations to evaluate the adsorption kinetics and thermodynamics. Results show that adsorption fitted to Langmuir model and followed a kinetic model of pseudo-second-order. The adsorption capacity of Pb(II) onto the Ch/Si/P composites membrane is 0.16 mmol/g. The relative selective factor (αf) value of Pb(II)/Rhodamine B is 2.38. This means that Pb(II) can be determined even in the presence of Rhodamine B interference.
Synthetic Studies of Bioactive Substances of 4-Hydroxybenzalhydantoin Derivatives
Authors: Hidayat IW , Sumiarsa D , Permatasari M , AKania  , Riska  , Priani L 
Published: February 2017

Abstract
4-hydroxybenzalhydantoin derivatives were synthesized by the condensation reaction between benzaldehydes 12-13 and substituted hydantoins 14-16 under standard conditions of reflux in glacial acetic acid, in the present of sodium acetate and a little amount of acetic anhydride as a catalyst. All compounds were identified by spectral analysis to give 4-hydroxybenzalhydantoins 17-21.
Simple Colorimetric Sensor for Trinitrotoluene Testing
Authors: Samanman S , Masoh N , Salah Y , Srisawat S , Wattanayon R , Wangsirikul P , Phumivanichakit K 
Published: February 2017

Abstract
A simple operating colorimetric sensor for trinitrotoluene (TNT) determination using a commercial scanner as a captured image was designed. The sensor is based on the chemical reaction between TNT and sodium hydroxide reagent to produce the color change within 96 well plates, which observed finally, recorded using a commercial scanner. The intensity of the color change increased with increase in TNT concentration and could easily quantify the concentration of TNT by digital image analysis using the Image J free software. Under optimum conditions, the sensor provided a linear dynamic range between 0.20 and 1.00 mg mL-1(r = 0.9921) with a limit of detection of 0.10± 0.01 mg mL-1. The relative standard deviation for eight experiments for the sensitivity was 3.8%. When applied for the analysis of TNT in two soil extract samples, the concentrations were found to be non-detectable to 0.26±0.04 mg mL-1. The obtained recovery values (93-95%) were acceptable for soil samples tested.
Historical connections between early marine science research and dissemination: the case study of aquarium Vasco Da Gama (Portugal) from late 19th century to mid-20th century
Authors: Pinto Bruno 
Published: February 2017

AbstractIn the late 19th century, there was a bloom of public aquariums throughout Europe. Some of them were built for entertainment purposes, whereas others were connected to marine science stations. This article explores the origins and development of the aquarium/marine research station Vasco da Gama (Portugal) as an example of this duality. Initially, the aquarium was created in 1898 by the Portuguese Society of Geography, in a political context of national affirmation. In the first years, a deficient establishment, lack of financial resources, and scarce technical knowledge contributed for its degradation. Therefore, the Navy took over the aquarium in the early 1900s, delivering its management some years later to the Portuguese Society of Natural Sciences. After improvements and modifications, it became one of the first marine biological stations in 1919. This was important for the development of national marine science research at a time of scarce resources. Despite many years of a symbiotic relation between science research and dissemination, the demolition of part of the aquarium/marine station due to a road construction in 1940 brought issues of disequilibrium between both functions. This eventually led to the separation of aquarium and marine station in 1950. Other themes such as connections to national and international institutions are also discussed.
Study of the progenitor of the magnetar 1E 2259+586 through Suzaku observations of the associated supernova remnant CTB 109
Authors: Nakano Toshio , Murakami Hiroaki , Furuta Yoshihiro , Enoto Teruaki , Masuyama Miyu , Shigeyama Toshikazu , Makishima Kazuo 
Published: February 2017

Abstract
We present a study of the progenitor of the magnetar 1E 2259+586, from Suzaku observations of the associated supernova remnant CTB 109. The Suzaku spectra, either spatially integrated or spatially resolved, were successfully described by a two-component plasma model, which reconfirms a previous Chandra result on the northwestern part of this remnant (Sasaki et al. 2013, A&A, 552, A45). The hotter component, with a temperature of ∼0.7 keV, can be identified as the stellar ejecta heated by reverse shock, because its contribution increases towards the remnant center. The cooler one, with a temperature of ∼0.25 keV, can be identified as the shocked interstellar matter. The abundances of Ne, Mg, Si, and S of the hotter component support these identifications. The total masses of the cooler and hotter components are estimated to be 220 ± 40 M⊙ and 42 ± 11 M⊙, respectively. The remnant is considered to be adiabatically expanding as in the Sedov–Taylor phase. The explosion energy, estimated to be 1.0 × 1051 erg by a canonical Sedov model, is typical of a core-collapse supernova explosion. Assuming that the hotter component includes the ejecta as well as the matter lost by the progenitor star via stellar winds, 1E 2259+586 is inferred to have originated from a very massive star.
Spontaneous Breathing during Extracorporeal Membrane Oxygenation in Acute Respiratory Failure
Authors: Crotti Stefania , Bottino Nicola , Ruggeri Giulia Maria , Spinelli Elena , Tubiolo Daniela , Lissoni Alfredo , Protti Alessandro , Gattinoni Luciano 
Published: February 2017

Abstract

Background
We evaluate the clinical feasibility of spontaneous breathing on extracorporeal membrane oxygenation and the interactions between artificial and native lungs in patients bridged to lung transplant or with acute exacerbation of chronic obstructive pulmonary disease (COPD) or acute respiratory distress syndrome.

Methods
The clinical course of a total of 48 patients was analyzed. Twenty-three of 48 patients were enrolled in the prospective study (nine bridged to lung transplant, six COPD, and eight acute respiratory distress syndrome). The response to the carbon dioxide removal was evaluated in terms of respiratory rate and esophageal pressure swings by increasing (“relief” threshold) and decreasing (“distress” threshold) the extracorporeal membrane oxygenation gas flow, starting from baseline condition.

Results
Considering all 48 patients, spontaneous breathing extracorporeal membrane oxygenation was performed in 100% bridge to lung transplant (9 of 9 extubated), 86% COPD (5 of 6 extubated), but 27% acute respiratory distress syndrome patients (6 of 8 extubated; P < 0.001) and was maintained for 92, 69, and 38% of the extracorporeal membrane oxygenation days (P = 0.021), respectively. In all the 23 patients enrolled in the study, gas flow increase (from 2.3 ± 2.2 to 9.2 ± 3.2 l/min) determined a decrease of both respiratory rate (from 29 ± 6 to 8 ± 9 breaths/min) and esophageal pressure swings (from 20 ± 9 to 4 ± 4 cm H2O; P < 0.001 for all). All COPD and bridge to lung transplant patients were responders (reached the relief threshold), while 50% of acute respiratory distress syndrome patients were nonresponders.

Conclusions
Carbon dioxide removal through extracorporeal membrane oxygenation relieves work of breathing and permits extubation in many patients, mainly bridge to lung transplant and COPD. Only few patients with acute respiratory distress syndrome were able to perform the spontaneous breathing trial, and in about 50% of these, removal of large amount of patient’s carbon dioxide production was not sufficient to prevent potentially harmful spontaneous respiratory effort.
Expansion of Prosodic Abilities at the Transition From Babble to Words: A Comparison Between Children With Cochlear Implants and Normally Hearing Children
Authors: Pettinato Michèle , Clerck Ilke De , Verhoeven Jo , Gillis Steven 
Published: February 2017

Objectives:
This longitudinal study examined the effect of emerging vocabulary production on the ability to produce the phonetic cues to prosodic prominence in babbled and lexical disyllables of infants with cochlear implants (CI) and normally hearing (NH) infants. Current research on typical language acquisition emphasizes the importance of vocabulary development for phonological and phonetic acquisition. Children with CI experience significant difficulties with the perception and production of prosody, and the role of possible top-down effects is, therefore, particularly relevant for this population.

Design:
Isolated disyllabic babble and first words were identified and segmented in longitudinal audio–video recordings and transcriptions for nine NH infants and nine infants with CI interacting with their parents. Monthly recordings were included from the onset of babbling until children had reached a cumulative vocabulary of 200 words. Three cues to prosodic prominence, fundamental frequency (f0), intensity, and duration, were measured in the vocalic portions of stand-alone disyllables. To represent the degree of prosodic differentiation between two syllables in an utterance, the raw values for intensity and duration were transformed to ratios, and for f0, a measure of the perceptual distance in semitones was derived. The degree of prosodic differentiation for disyllabic babble and words for each cue was compared between groups. In addition, group and individual tendencies on the types of stress patterns for babble and words were also examined.

Results:
The CI group had overall smaller pitch and intensity distances than the NH group. For the NH group, words had greater pitch and intensity distances than babbled disyllables. Especially for pitch distance, this was accompanied by a shift toward a more clearly expressed stress pattern that reflected the influence of the ambient language. For the CI group, the same expansion in words did not take place for pitch. For intensity, the CI group gave evidence of some increase of prosodic differentiation. The results for the duration measure showed evidence of utterance final lengthening in both groups. In words, the CI group significantly reduced durational differences between syllables so that a more even-timed, less differentiated pattern emerged.

Conclusions:
The onset of vocabulary production did not have the same facilitatory effect for the CI infants on the production of phonetic cues for prosody, especially for pitch. It was argued that the results for duration may reflect greater articulatory difficulties in words for the CI group than the NH group. It was suggested that the lack of clear top-down effects of the vocabulary in the CI group may be because of a lag in development caused by an initial lack of auditory stimulation, possibly compounded by the absence of auditory feedback during the babble phase.
The Impact of a Cochlear Implant Electrode Array on the Middle Ear Transfer Function
Authors: Pazen David , Anagiotos Andreas , Nünning Maike , Gostian Antoniu-Oreste , Ortmann Magdalene , Beutner Dirk 
Published: February 2017

Objectives:As a treatment for partial deafness with residual hearing in the lower frequency range, the combined acoustic and electric stimulation of the cochlea has become widespread. Acoustic stimulation is provided by a hearing aid’s airborne sound and the electric stimulation by a cochlear implant electrode array, which may be inserted through the round window or a cochleostomy. To take advantage of that concept, it is essential to preserve residual hearing after surgery. Therefore, the intracochlear electrode array should not compromise the middle ear vibration transmission. This study investigates the influence of different electrode types and insertion paths on the middle ear transfer function and the inner ear fluid dynamics.Design:Sound-induced oval and round window net volume velocities were calculated from vibration measurements with laser vibrometers on six nonfixated human temporal bones. After baseline measurements in the “natural” condition, a cochleostomy was drilled and closed with connective tissue. Then, four different electrode arrays were inserted through the cochleostomy. Afterwards, they were inserted through the round window while the cochleostomy was patched again with connective tissue.Results:After having drilled a cochleostomy and electrode insertion, no systematic trends in the changes of oval and round window volume velocities were observed. Nearly all changes of middle ear transfer functions, as well as oval and round window volume velocity ratios, were statistically insignificant.Conclusions:Intracochlear electrode arrays do not significantly increase cochlear input impedance immediately after insertion. Any changes that may occur seem to be independent of electrode array type and insertion path.
Speech Intelligibility as a Cue for Acceptable Noise Levels
Authors: Recker Karrie L. , Micheyl Christophe 
Published: February 2017

Objectives:
The goal of this study was to examine whether individuals are using speech intelligibility to determine how much noise they are willing to accept while listening to running speech. Previous research has shown that the amount of background noise that an individual is willing to accept while listening to speech is predictive of his or her likelihood of success with hearing aids. If it were possible to determine the criterion by which individuals make this judgment, then it may be possible to alter this cue, especially for those who are unlikely to be successful with hearing aids, and thereby improve their chances of success with hearing aids.

Design:
Twenty-one individuals with normal hearing and 21 with sensorineural hearing loss participated in this study. In each group, there were 7 with a low, moderate, and high acceptance of background noise, as determined by the Acceptable Noise Level (ANL) test. (During the ANL test, listeners adjusted speech to their most comfortable listening level, then background noise was added, and they adjusted it to the maximum level that they were “willing to put up with” while listening to the speech.) Participants also performed a modified version of the ANL test in which the speech was fixed at four different levels (50, 63, 75, and 88 dBA), and they adjusted only the level of the background noise. The authors calculated speech intelligibility index (SII) scores for each participant and test level. SII scores ranged from 0 (no speech information is present) to 1 (100% of the speech information is present). The authors considered a participant’s results to be consistent with a speech intelligibility-based listening criterion if his or her SIIs remained constant across all of the test conditions.

Results:
For all but one of the participants with normal hearing, their SIIs remained constant across the entire 38-dB range of speech levels. For all participants with hearing loss, the SII increased with speech level.

Conclusions:
For most listeners with normal hearing, their ANLs were consistent with the use of speech intelligibility as a listening cue; for listeners with hearing impairment, they were not. Future studies should determine what cues these individuals are using when selecting an ANL. Having a better understanding of these cues may help audiologists design and optimize treatment options for their patients.
Validation of the INCEPT: A Multisource Feedback Tool for Capturing Different Perspectives on Physicians' Professional Performance
Authors: van der Meulen Mirja W. , Boerebach Benjamin C. M. , Smirnova Alina , Heeneman Sylvia , oude Egbrink Mirjam G. A. , van der Vleuten Cees P. M. , Arah Onyebuchi A. , Lombarts Kiki M. J. M. H. 
Published: February 2017

Introduction:
Multisource feedback (MSF) instruments are used to and must feasibly provide reliable and valid data on physicians' performance from multiple perspectives. The “INviting Co-workers to Evaluate Physicians Tool” (INCEPT) is a multisource feedback instrument used to evaluate physicians' professional performance as perceived by peers, residents, and coworkers. In this study, we report on the validity, reliability, and feasibility of the INCEPT.

Methods:
The performance of 218 physicians was assessed by 597 peers, 344 residents, and 822 coworkers. Using explorative and confirmatory factor analyses, multilevel regression analyses between narrative and numerical feedback, item-total correlations, interscale correlations, Cronbach's α and generalizability analyses, the psychometric qualities, and feasibility of the INCEPT were investigated.

Results:
For all respondent groups, three factors were identified, although constructed slightly different: “professional attitude,” “patient-centeredness,” and “organization and (self)-management.” Internal consistency was high for all constructs (Cronbach's α ≥ 0.84 and item-total correlations ≥ 0.52). Confirmatory factor analyses indicated acceptable to good fit. Further validity evidence was given by the associations between narrative and numerical feedback. For reliable total INCEPT scores, three peer, two resident and three coworker evaluations were needed; for subscale scores, evaluations of three peers, three residents and three to four coworkers were sufficient.

Discussion:
The INCEPT instrument provides physicians performance feedback in a valid and reliable way. The number of evaluations to establish reliable scores is achievable in a regular clinical department. When interpreting feedback, physicians should consider that respondent groups' perceptions differ as indicated by the different item clustering per performance factor.
Basement Membrane Matrix Promotes the Efficiency of Hair Follicle Reconstruction In Vivo and Is a Cell Delivery Vehicle for Follicle Regeneration
Authors: Xiao Shune , Miao Yong , Wang Jin , Lin Bojie , Hu Zhiqi 
Published: February 2017

BACKGROUND
The efficiency of hair follicle (HF) reconstruction is decreased by extensive apoptotic remodeling that occurs soon after grafting.

OBJECTIVE
To evaluate a basement membrane matrix (matrix) to improve the efficiency of HF reconstruction and serve as a cell delivery vehicle.

MATERIALS AND METHODS
Newborn mouse skin cells were suspended in a matrix and transplanted in a chamber assay. The viability and proliferation of mouse dermal papilla cells seeded in the matrix were tested. Dermal papilla cells and epidermal cells seeded in matrix sheets were grafted into nude mice to observe hair formation.

RESULTS
The matrix significantly shortened the time to hair formation. The first hair shafts appeared within the matrix at 17.67 ± 1.21 days versus 23.00 ± 1.41 days for Dulbecco's modified Eagle medium controls. There was a significant difference (p < .05) in the number of newly formed hairs in areas of reconstructed skin with the matrix (100 μL) grafts (323 ± 12) versus controls (276 ± 11). Dermal papilla cells were successfully cultured in the matrix, and hair formation was dense when the matrix was used as a cell delivery vehicle for follicle reconstruction.

CONCLUSION
The matrix improved the efficiency of HF reconstruction and was a suitable delivery vehicle of cells for HF engineering.
Changes in the Lipidomic Profile of Aqueous Humor in Open-Angle Glaucoma
Authors: Cabrerizo Javier , Urcola Javier A. , Vecino Elena 
Published: February 2017

Purpose:
To identify and determine differences in lipid profiles of aqueous humor (AH) in patients with open-angle glaucoma (OAG).

Materials and Methods:
The lipidomic profile of 10 samples of AH of patients with OAG and 10 controls was analyzed. Patients with a history of anterior segment surgery, anterior segment pathology, or intraocular injections were excluded. Topical ocular medications within the last 6 months were reported. AH was obtained during the first step of nonperforating deep sclerotomy in OAG patients and during refractive lensectomy in controls. Lipidomic ultra-performance liquid chromatography mass spectrometry was used to perform an optimal profiling of glycerolipids, sterol lipids, sphingolipids, and glycerophospholipids. Metabolite extraction was accomplished by fractionating the samples into pools of species with similar physicochemical properties.

Results:
The levels of 37 of 110 lipids changed in OAG when compared with controls samples. The concentration of most diacylglycerophosphocholines and 1-ether, 2-acylglycerophosphocholines increases in OAG when compared with healthy controls. In addition, 14 sphingomyelins increased significantly, up to 2.75-fold, in OAG. 5 cholesteryl esters are also present at higher levels in OAG when compared with controls.

Conclusions:
The lipid composition of AH in OAG patients shows differences when compared with healthy individuals. Changes in lipid synthesis may relate to oxidative stress metabolic response in OAG and may play an important role in the pathophysiology of the disease.