bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myocardial deformation in pediatric patients with mucopolysaccharidoses: A two‐dimensional speckle tracking echocardiography study
Authors: Borgia Francesco , Pezzullo Enrica , Schiano Lomoriello Vincenzo , Sorrentino Regina , Lo Iudice Francesco , Cocozza Sara , Della Casa Roberto , Parenti Giancarlo , Strisciuglio Pietro , Trimarco Bruno , Galderisi Maurizio 
Published: January 2017

BackgroundMucopolysaccharidoses (MPS) are inherited lysosomal storage disorders caused by deficiency of required glycosaminoglycans breakdown enzymes, inducing cardiac involvement. Little is known about myocardial deformation involvement inMPS. Our aim was to assess biventricular structure and function in asymptomatic children withMPSusing standard echo Doppler and 2D speckle tracking (STE).MethodsFifteenMPSchildren (one type I, six typeII, three typeIIIA, oneIIIB, threeIVA, oneVI), asymptomatic for cardiac symptoms, and 15 age and sex‐matched healthy controls underwent echo Doppler andSTE. Left ventricular (LV) wall thicknesses, diameters, and mass were normalized byz‐score.LVglobal longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS) at papillary muscles,LVtwisting, and right ventricular (RV)GLSwere measured.ResultsThe two groups were comparable for body mass index, heart rate, and blood pressure.LVmass index and relative wall thickness were higher inMPS. Ejection fraction (EF), and s′ velocity did not differ between the two groups. E/A ratio was lower and E/e′ higher inMPS. Tricuspid annular plane systolic excursion,RVs′ and e′ were lower inMPS.LV GLSdid not differ between the two groups, butGCS(P=.014),GRS(P=.023), twisting (P=.012), andRV GLS(P<.001) were lower in theMPSgroup.ConclusionsLVstrain abnormalities are detectable inMPSpediatric patients, independently ofMPStype, when EF is still normal.RV GLSis also involved consensually withTAPSEreduction.STEcan be useful for detection of subclinical myocardial damage inMPS.
Mitral valve resistance determines hemodynamic consequences of severe rheumatic mitral stenosis and immediate outcomes of percutaneous valvuloplasty
Authors: Sanati Hamidreza , Zolfaghari Reza , Samiei Niloufar , Rezaei Yousef , Chitsazan Mitra , Zahedmehr Ali , Shakerian Farshad , Kiani Reza , Firouzi Ata , Rezaei Tabrizi Reza 
Published: January 2017

IntroductionThe mitral valve area (MVA) poorly reflects the hemodynamic status of (MS). In this study, we compared the MVA with mitral valve resistance (MVR) with regard to the determination of hemodynamic consequences of MS and the immediate outcomes of percutaneous balloon mitral valvuloplasty (PBMV).MethodsIn a prospective study, 36 patients with severe rheumatic MS with left ventricular ejection fraction (LVEF) >50% were evaluated. They underwent transthoracic echocardiography (TTE) and catheterization. The MVA was measured by two‐dimensional planimetry and pressure half‐time (PHT), and the MVR was calculated using the equation: 1333 × transmitral pressure gradient mean transmitral diastolic flow rate.ResultsThe patients’ mean age was 47.8±10.5 years. MVR ≥140.6 dynes·s/cm5 detected systolic pulmonary arterial pressure (sPAP) >55 mm Hg with a sensitivity of 100% and a specificity of 74%. The sensitivity and specificity of MVA<0.75 cm2 to discriminate elevated sPAP were 81% and 89%, respectively. PHT ≥323.5 mseconds had a sensitivity of 78% and a specificity of 96% to detect an elevated sPAP. To predict a successful PBMV, preprocedural MVR ≥106.1 dynes·s/cm5 had a sensitivity of 100% and a specificity of 67% (area under the curve [AUC]=0.763; 95% confidence interval [CI]=0.520‐1.006; P=.034); preprocedural MVA <0.95 cm2 had a sensitivity of 78% and a specificity of 73% (AUC=0.730; 95% CI=0.503‐0.956; P=.065); and preprocedural PHT ≥210.5 mseconds had a sensitivity of 73% and a specificity of 78% (AUC=0.707; 95% CI=0.474‐0.941; P=.095).ConclusionsMVR seems to be more accurate than MVA in determining the hemodynamic consequences of severe MS as determined by sPAP. In addition, preprocedural MVR detected successful PBMVs.
Tape casting system for ULTCCs to fabricate multilayer and multimaterial 3D electronic packages with embedded electrodes
Authors: Chen Mei‐Yu , Vahera Timo , Hsi Chi‐Shiung , Sobocinski Maciej , Teirikangas Merja , Peräntie Jani , Juuti Jari , Jantunen Heli 
Published: January 2017

AbstractA 3D multilayer structure built by two ultra‐low temperature co‐fired ceramic (ULTCC) compositions with silver embedded electrodes are co‐fired at a temperature of 450°C. The 3D multilayer module is prepared by laminating the ULTCC green tapes with a new binder system, which organics can be completely burned out at temperature of 250°C before the sintering of the ULTCC 3D modulus. High‐density microstructures are achieved for the sintered module. In this study, the ULTCC feasible binder system is introduced. Also, ULTCC multilayers and multimaterial structures with surface and embedded silver electrodes are fabricated. This research opens up a new horizon for fabrication of electroceramic devices with embedded electrodes in multimaterial devices.
Emission from Mo‐O charge‐transfer state and Yb3+ emission in Eu3+‐doped and nondoped molybdates under UV excitation
Authors: Qiao Xuebin , Tsuboi Taiju 
Published: January 2017

AbstractMolybdates of Li+ and Yb3+ are studied to investigate the luminescence under UV excitation. LiYb(MoO4)2 and Eu3+‐doped LiYb1‐xEux(MoO4)2 (x=001–1.0) phosphors were synthesized by solid state reaction under mixing of Eu2O3, Yb2O3, Li2CO3 and MoO2 in air atmosphere. Two broad absorption bands centered at 333 and 236 nm are observed in LiYb(MoO4)2 compound. They are attributed to the 1A1→1T1 and 1T2 transitions due to the O2−→Mo6+ electron transfers in MoO4 tetrahedron. An emission band with a peak at about 440 nm is found, which is attributed to the 3T1→1A1 transition of MoO4. Appearance of near‐infrared (NIR) Yb3+ emission observed under UV excitation is understood by the MoO4→Yb3+ Foerster‐Type energy transfer due to spectral overlap between the low‐energy tail of the broad 440 nm emission band and the high‐energy tail of the broad Yb3+ absorption band and due to short Yb3+‐MoO4 distance. Yb3+ emission observed in LiYb1−xEux(MoO4)2 by Eu3+ excitation is understood by the Eu3+→Yb3+ energy transfer by cross‐relaxation (CR) process between the 5D0→7F6 Eu3+ transition and the 2F7/2→2F5/2 Yb3+ transition. The CR efficiency shows maximum efficiency of 0.24 at x=0.15 of higher acceptor Yb3+ concentration than donor Eu3+ concentration. Three Yb3+ emission bands with peaks at 994, 1002, and 1023 nm are observed, depending on the excitation wavelength. This is explained by less‐shielded 4f electrons of Yb3+ by the 5s25p6 outermost electron shells, which are also responsible for unusual broadband Yb3+ absorption and emission. From appearance of NIR Yb3+ emission under excitation by not only UV light but also red light, these compounds are expected to be suitable for efficient photovoltaic application to Si‐based solar cells.
Fabrication of Ti(C,N)‐based cermets by in situ carbothermal reduction of MoO3 and subsequent liquid sintering
Authors: Zhou Wei , Zheng Yong , Zhao Yijie , Zhang Guotao , Dong Zuowei , Xiong Weihao 
Published: January 2017

AbstractTi(C,N)‐based cermets were fabricated by in situ carbothermal reduction of MoO3 and subsequent liquid sintering in a single heating process. The densification behavior, phase formation, and microstructure evolution of the cermets were characterized by DSC, XRD, SEM, and TEM. The results showed that near‐fully dense Ti(C,N)‐based cermets with fine carbonitride grains could be obtained by the above‐mentioned method. The carbonitride grains of the cermets still exhibited typical core/rim structures and evenly distributed in the binder phase, but the rim phase was more complete and thinner compared with traditional cermets. In addition, the interfaces between the ceramic phase and binder phase of the cermets were atomically smooth, having the orientation relationship of ()R//(110)B with a perfect coherency state. The prepared Ti(C,N)‐based cermets produced with MoO3 showed excellent comprehensive mechanical properties having a transverse rupture strength of 2461±62 MPa, a Rockwell hardness of 88.0±0.1 HRA, and a fracture toughness of 22.3±0.4 MPa·m1/2, respectively.
Abused women's experiences of a primary care identification and referral intervention: a case study analysis
Authors: Bradbury‐Jones Caroline , Clark Maria , Taylor Julie 
Published: January 2017

AbstractAimsThe aim of this study was to report the findings of a qualitative case study that investigated abused women's experiences of an identification and referral intervention and to discuss the implications for nurses, specifically those working in primary and community care.BackgroundDomestic violence and abuse is a significant public health issue globally but it is a hidden problem that is under‐reported. In the UK, Identification and Referral to Improve Safety is a primary care‐based intervention that has been found to increase referral rates of abused women to support and safety services. This paper reports on the findings of an evaluation study of two sites in England.DesignQualitative study with a case study design.MethodsIn line with case study design, the entire evaluation study employed multiple data collection methods. We report on the qualitative interviews with women referred through the programme. The aim was to elicit their experiences of the three aspects of the intervention: identification; referral; safety. Data collection took place March 2016.FindingsTen women took part. Eight had exited the abusive relationship but two remained with the partner who had perpetrated the abuse. Women were overwhelmingly positive about the programme and irrespective of whether they had remained or exited the relationship all reported perceptions of increased safety and improved health.ConclusionNurses have an important role to play in identifying domestic violence and abuse and in referral and safety planning. As part of a portfolio of domestic violence and abuse interventions, those that empower women to take control of their safety (such as Identification and Referral to Improve Safety) are important.
Jewish Cuba's Contact Zone: Transnational Encounters in Havana's Adath Israel Synagogue
Authors: Weinreb Amelia Rosenberg 
Published: January 2017

ResumenInmediatamente después de la liberalización constitucional de 1991 en la que Cuba se declaró ser un estado laico, en lugar de un estado ateo, Adath Israel, la única sinagoga ortodoxa de La Habana, reabrió sus puertas. La sinagoga pronto dio la bienvenida acogió a un flujo de viajeros internacionales, que llegaron con entusiasmo, curiosidad y fondos. La consiguiente revitalización de Cuba judía ha recibido una cantidad desproporcionada de atención académica, periodística y turística en los últimos veinte años, y el interés mundial en esta pequeña comunidad sigue creciendo. Sin embargo, se ha prestado poca atención analítica explícita a la relación que ha surgido entre los cubanos judíos y sus invitados extranjeros . Mi argumento central, basado en la observación‐participante en Adath Israel, es que la Cuba judía ya no constituye un objeto cultural de análisis, sino que se entiende mejor como una “zona de contacto” transnacional, caracterizada por las tensiones y las conexiones del afecto colectivo, una economía del regalo, y los cambios de sentidos que se producen en en el seno del Pueblo Judío a través del encuentro.
Src and phospho‐FAK kinases are activated by allopregnanolone promoting Schwann cell motility, morphology and myelination
Authors: Melfi Simona , Montt Guevara Maria Magdalena , Bonalume Veronica , Ruscica Massimiliano , Colciago Alessandra , Simoncini Tommaso , Magnaghi Valerio 
Published: January 2017

AbstractSchwann cells' (SCs) development and maturation require coordinate and complementary activation of several signals and intracellular pathways. Among factors controlling these processes, the signalling intermediates Src tyrosine kinase and focal adhesion kinase (FAK) are relevant for SCs', participating in regulation of their adhesion, motility and migration. Recently, the progesterone metabolite allopregnanolone (ALLO) was proved to be synthesized by SCs, whereas it acts autocrinally on SCs motility and proliferation, which are crucial processes for nerve development, maturation and regeneration.Herein, we investigate the hypothesis that the molecular mechanisms behind the ALLO's action on SCs involve the signalling intermediates Src and FAK. We first demonstrated that ALLO 10−6 M regulates SCs morphology, motility and myelination, also increasing the internode distance in the in vitro myelination model of neuron/SCs co‐culture. ALLO's actions were mediated by the modulation of Src/FAK pathway, since they were counteracted by PP2 10−5 M, a selective inhibitor of Src kinase. Then, we proved that Src/FAK activation in SCs involves GABA‐A dependent mechanisms and actin re‐arrangements. In conclusion, our findings are the first to corroborate the importance of the neuroactive steroid ALLO in regulating SCs development and maturation via the Src and phospho‐FAK signalling activation.
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Cover Image for this issue: doi: 10.1111/jnc.13795.
Violated and vulnerable: women's experiences of contracting a sexually transmitted infection from a male partner
Authors: East Leah , Peters Kath , Jackson Debra 
Published: January 2017

Aims and objectivesTo explore women's stories of contracting a sexually transmitted infection from a male partner and elucidate the gendered constructs and violence experienced that made the women vulnerable to these infections.BackgroundViolence against women can result in both physical and psychological consequences and expose women to multiple health risks including sexual health adversity.DesignFeminist storytelling approach.MethodsQualitative interviews were conducted with 10 women. All data underwent thematic analysis.FindingsFindings from this study revealed the women were vulnerable to contracting sexually transmitted infection/s from their male sexual partners as a result of unequal gender and abusive relationship dynamics. Subsequently, contracting a sexual infection within this context potentially increased their vulnerability in both current and future relationships, through their loss of self‐confidence and perceived ability to have a trusting loving heterosexual relationship as women with sexually transmitted infection/s.ConclusionWomen in relationships in which they are subordinate to their male partner are at heightened risk of sexual health adversity, including contracting a sexually transmitted infection. Contracting a sexually transmitted infection within the context of an abusive relationship can further increase women's vulnerability to dominant male partners, thus further exposure to sexual risk and adversity.Relevance to clinical practiceNurses working in clinical settings are well placed to conduct opportunistic screening of women's sexual health, including assessment of sexually transmitted infections and the nature of the encounter in which they were contracted. Thorough assessment can potentially identify relationship and personal factors that can increase a woman's risk to both sexual adversity and forms of abuse. Also, if women do divulge that they have suffered abuse, nurses are positioned to provide support and guidance in implementing strategies to minimise risk as well as referring them to specialised services.
Automated measurement of pressure injury through image processing
Authors: Li Dan , Mathews Carol 
Published: January 2017

Aims and objectivesTo develop an image processing algorithm to automatically measure pressure injuries using electronic pressure injury images stored in nursing documentation.BackgroundPhotographing pressure injuries and storing the images in the electronic health record is standard practice in many hospitals. However, the manual measurement of pressure injury is time‐consuming, challenging and subject to intra/inter‐reader variability with complexities of the pressure injury and the clinical environment.DesignA cross‐sectional algorithm development study.MethodsA set of 32 pressure injury images were obtained from a western Pennsylvania hospital. First, we transformed the images from an RGB (i.e. red, green and blue) colour space to a YCbCr colour space to eliminate inferences from varying light conditions and skin colours. Second, a probability map, generated by a skin colour Gaussian model, guided the pressure injury segmentation process using the Support Vector Machine classifier. Third, after segmentation, the reference ruler – included in each of the images – enabled perspective transformation and determination of pressure injury size. Finally, two nurses independently measured those 32 pressure injury images, and intraclass correlation coefficient was calculated.ResultsAn image processing algorithm was developed to automatically measure the size of pressure injuries. Both inter‐ and intra‐rater analysis achieved good level reliability.ConclusionsValidation of the size measurement of the pressure injury (1) demonstrates that our image processing algorithm is a reliable approach to monitoring pressure injury progress through clinical pressure injury images and (2) offers new insight to pressure injury evaluation and documentation.Relevance to clinical practiceOnce our algorithm is further developed, clinicians can be provided with an objective, reliable and efficient computational tool for segmentation and measurement of pressure injuries. With this, clinicians will be able to more effectively monitor the healing process of pressure injuries.
The impact of evidence‐based sepsis guidelines on emergency department clinical practice: a pre‐post medical record audit
Authors: Romero Bernadine , Fry Margaret , Roche Michael 
Published: January 2017

Aims and objectivesTo explore the number of patients presenting with sepsis before and after guideline implementation; the impact of sepsis guidelines on triage assessment, emergency department management and time to antibiotics.BackgroundSepsis remains one of the leading causes of mortality and morbidity within hospitals. Globally, strategies have been implemented to reduce morbidity and mortality rates, which rely on the early recognition and management of sepsis. To improve patient outcomes, the New South Wales government in Australia introduced sepsis guidelines into emergency departments. However, the impact of the guidelines on clinical practice remains unclear.Design/MethodsA 12‐month pre‐post retrospective randomised medical record audit of adult patients with a sepsis diagnosis. Data were extracted from the emergency department database and paper medical record. Data included patient demographic (age, gender), clinical information (time of arrival, triage code, seen by time, disposition, time to antibiotic, pathology, time to intravenous fluids) and patient assessment data (heart rate, respiratory rate, blood pressure, temperature, oxygen saturations, medication).ResultsThis study demonstrated a statistically significant 230‐minute reduction in time to antibiotics post implementation of the guidelines. The post group (n = 165) received more urgent triage categories (n = 81; 49·1%), a 758‐minute reduction in mean time to second litre of intravenous fluids and an improvement in collection of lactate (n = 112, 67·9%), also statistically significant.ConclusionsThe findings highlight the impact the guidelines can have on clinician decision‐making and behaviour that support best practice and positive patient outcomes. The sepsis guidelines improved the early assessment, recognition and management of patients presenting with sepsis in one tertiary referral emergency department.Relevance to clinical practiceThe use of evidenced‐based guidelines can impact clinical decision‐making and behaviour, resulting in the translation and support of best practice and improving patient care.
Multi Cumulative Prospect Theory and the Demand for Cliquet‐Style Guarantees
Authors: Ruß Jochen , Schelling Stefan 
Published: January 2017

AbstractExpected Utility Theory (EUT) and Cumulative Prospect Theory (CPT) face problems explaining preferences of long‐term investors. Previous research motivates that the subjective utility of a long‐term investment also depends on interim value changes. Therefore, we propose an approach that we call Multi Cumulative Prospect Theory. It is based on CPT and considers annual changes in the contract values. As a first application, we can show that in contrast to EUT and CPT, this approach is able to explain the demand for guaranteed products with lock‐in features, which in this framework generate a higher subjective utility than products without or with simpler guarantees.
Hepatitis B virus reactivation in breast cancer patients undergoing chemotherapy: A review and meta‐analysis of prophylaxis management
Authors: Liu Z. , Jiang L. , Liang G. , Song E. , Jiang W. , Zheng Y. , Gong C. 
Published: January 2017

SummaryHepatitis B virus (HBV) reactivation during or after chemotherapy in patients with breast cancer has become a remarkable clinical problem. Prophylactic nucleos(t)ide analogues (NAs) are recommended for patients with breast cancer who are hepatitis B surface antigen (HBsAg) positive before chemotherapy. We performed an up‐to‐date meta‐analysis to compare the efficacy of prophylactic lamivudine use with nonprophylaxis in HBsAg‐positive breast cancer patients undergoing chemotherapy. PubMed, the Cochrane Library and China National Knowledge Infrastructure (CNKI) databases were searched for relevant articles until June 2016. Eligible articles comparing the efficacy of prophylactic lamivudine use with nonprophylaxis in HBsAg‐positive breast cancer patients undergoing chemotherapy were identified. Eight studies which had enrolled 709 HBsAg‐positive breast cancer patients undergoing chemotherapy were analysed. Lamivudine prophylaxis significantly reduced the rates of chemotherapy‐associated hepatitis B flares in chronic hepatitis B in breast cancer compared with patients with nonprophylaxis (odds ratio [OR]=0.15, 95% confidence interval [CI]: 0.07‐0.35, P<.00001). Chemotherapy disruption rates attributed to HBV reactivation in the prophylaxis groups were significantly lower than the nonprophylaxis groups (OR=0.17, 95% CI: 0.07‐0.43, P=.0002). Patients with lamivudine prophylaxis had a higher risk for tyrosine‐methionine‐aspartate‐aspartate (YMDD) motif mutations than patients with nonprophylaxis (OR=6.33, 95% CI: 1.01‐39.60, P=.05). Prophylactic antiviral therapy management is necessary for HBsAg‐positive breast cancer patients undergoing chemotherapy, in spite of high correlation with lamivudine‐resistant HBV variants with YMDD motif mutations.