bluuebunny/crossref_metadata_2025_split huggingface dataset:
FGF2 inhibits endothelial–mesenchymal transition through microRNA-20a-mediated repression of canonical TGF-β signaling
Authors: Correia Ana C. P. , Moonen Jan-Renier A. J. , Brinker Marja G. L. , Krenning Guido 
Published: January 2016

ABSTRACT
Endothelial-to-mesenchymal transition (EndMT) is characterized by the loss of endothelial cell markers and functions, and coincides with de novo expression of mesenchymal markers. EndMT is induced by TGFβ1 and changes endothelial microRNA expression. We found that miR-20a is decreased during EndMT, and that ectopic expression of miR-20a inhibits EndMT induction. TGFβ1 induces cellular hypertrophy in human umbilical vein endothelial cells and abrogates VE-cadherin expression, reduces endothelial sprouting capacity and induces the expression of the mesenchymal marker SM22α (also known as TAGLN). We identified ALK5 (also known as TGFBR1), TGFBR2 and SARA (also known as ZFYVE9) as direct miR-20a targets. Expression of miR-20a mimics abrogate the endothelial responsiveness to TGFβ1, by decreasing ALK5, TGFBR2 and SARA, and inhibit EndMT, as indicated by the maintenance of VE-cadherin expression, the ability of the cells to sprout and the absence of SM22α expression. FGF2 increases miR-20a expression and inhibits EndMT in TGFβ1-stimulated endothelial cells. In summary, FGF2 controls endothelial TGFβ1 signaling by regulating ALK5, TGFBR2 and SARA expression through miR-20a. Loss of FGF2 signaling combined with a TGFβ1 challenge reduces miR-20a levels and increases endothelial responsiveness to TGFβ1 through elevated receptor complex levels and activation of Smad2 and Smad3, which culminates in EndMT.
Consumer Social Responsibility
Authors: Pigors Mark , Rockenbach Bettina 
Published: January 2016

We investigate the emergence of socially responsible (SR) production through consumer decisions. Our experimental treatments vary market competitiveness and consumers’ information on social responsibility in production. We show that—irrespective of consumers’ information—SR production reduces monopolistic supplier’s profit and is therefore unlikely to emerge. With supplier competition, SR production positively influences consumers’ buying decisions and suppliers offering SR products achieve significantly higher profits, as long as their price is not too high. Our results yield valuable insights into the possibilities and limitations of promoting SR production through consumer behavior, and they provide evidence for positive effects of competition on moral behavior. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2015.2279 . This paper was accepted by Uri Gneezy, behavioral economics.
The custom triflange cup
Authors: Goodman G. P. , Engh Jr C. A. 
Published: January 2016

The custom triflange is a patient-specific implant for the treatment of severe bone loss in revision total hip arthroplasty (THA). Through a process of three-dimensional modelling and prototyping, a hydroxyapatite-coated component is created for acetabular reconstruction. There are seven level IV studies describing the clinical results of triflange components. The most common complications include dislocation and infection, although the rates of implant removal are low. Clinical results are promising given the challenging problem. We describe the design, manufacture and implantation process and review the clinical results, contrasting them to other methods of acetabular reconstruction in revision THA. Cite this article: Bone Joint J 2016;98-B(1 Suppl A):68–72.
The outcomes of instrumented posterolateral lumbar fusion in patients with rheumatoid arthritis
Authors: Kang C-N. , Kim C-W. , Moon J-K. 
Published: January 2016

Aims The aims of this study were to evaluate the clinical and radiological outcomes of instrumented posterolateral fusion (PLF) performed in patients with rheumatoid arthritis (RA). Methods A total of 40 patients with RA and 134 patients without RA underwent instrumented PLF for spinal stenosis between January 2003 and December 2011. The two groups were matched for age, gender, bone mineral density, the history of smoking and diabetes, and number of fusion segments. The clinical outcomes measures included the visual analogue scale (VAS) and the Korean Oswestry Disability Index (KODI), scored before surgery, one year and two years after surgery. Radiological outcomes were evaluated for problems of fixation, nonunion, and adjacent segment disease (ASD). The mean follow-up was 36.4 months in the RA group and 39.1 months in the non-RA group. Results Both groups had significant improvement in symptoms one year after surgery, while the RA group showed some deterioration of outcome scores owing to complications during the second year after surgery. Complications occurred at a higher rate in the group with RA (19 patients, 47.5%) than in those without RA (23 patients, 17.1%) (p < 0.001). A total of 15 patients in the RA group (37.5%) required revision surgery, mainly for implant failure and post-operative infection. Discussion Multimodal approaches should be considered when performing instrumented PLF in patients with RA to reduce the rate of complications, such as problems of fixation, post-operative infection and nonunion. Take home message: Specific strategies should be undertaken in order to optimise outcomes in patients with rheumatoid arthritis. Cite this article: Bone Joint J 2016;98-B:102–8.
Mid-flexion instability after total knee arthroplasty
Authors: Vince K. 
Published: January 2016

The term mid-flexion instability has entered the orthopaedic literature as a concept, but has not been confirmed as a distinct clinical entity. The term is used freely, sometimes as a synonym for flexion instability. However, the terms need to be clearly separated. A cadaver study published in 1990 associated joint line elevation with decreased stability at many angles of flexion, but that model was not typical of clinical scenarios. The literature is considered and it is proposed that the more common entity of an uncorrected flexion contracture after a measured resection arthroplasty technique is more likely to produce clinical findings that suggest instability mid-flexion.It is proposed that the clinical scenario encountered is generalised instability, with the appearance of stability in full extension from tight posterior structures.This paper seeks to clarify whether mid-flexion instability exists as an entity distinct from other commonly recognised forms of instability.Cite this article: Bone Joint J 2016;98-B(1 Suppl A):84–8.
Highly cross-linked polyethylene decreases the rate of revision of total hip arthroplasty compared with conventional polyethylene at 13 years’ follow-up
Authors: Hanna S. A. , Somerville L. , McCalden R. W. , Naudie D. D. , MacDonald S. J. 
Published: January 2016

AimsThe purpose of this study was to compare the long-term results of primary total hip arthroplasty (THA) in young patients using either a conventional (CPE) or a highly cross-linked (HXLPE) polyethylene liner in terms of functional outcome, incidence of osteolysis, radiological wear and rate of revision.MethodsWe included all patients between the ages of 45 and 65 years who, between January 2000 and December 2001, had undergone a primary THA for osteoarthritis at our hospital using a CPE or HXLPE acetabular liner and a 28 mm cobalt-chrome femoral head. From a total of 160 patients, 158 (177 hips) were available for review (CPE 89; XLPE 88). The mean age, body mass index (BMI) and follow-up in each group were: CPE: 56.8 years (46 to 65); 30.7 kg/m2(19 to 58); 13.2 years (2.1 to 14.7) and HXLPE: 55.6 years (45 to 65); BMI: 30 kg/m2(18 to 51); 13.1 years (5.7 to 14.4).ResultsThe mean Harris hip score (HHS) at final follow-up was 89.3 for the CPE group and 90.9 for the HXLPE group (p = 0.078). Osteolysis was present around 15 acetabular (17%) and 16 femoral (18%) components in the CPE hips compared with none (0%) in the HXLPE hips. The mean radiological linear wear of the CPE liners was 0.11 mm/year compared with 0.035 mm/year for the HXLPE liners (p = 0.006). The cumulative implant survival, with revision for polyethylene wear as the endpoint, was 86% (95% confidence interval 78 to 94) in the CPE group and 100% in the HXLPE group at 13 years (numbers at risk at 13 years - CPE: 65, XLPE: 61).DiscussionThis study shows that HXLPE liners are associated with significantly less osteolysis and a lower rate of revision THA than CPE liners at long-term follow-up. Take home message: The findings of this study highlight the clinical benefits of using HXLPE liners in THA and support the routine use of the material in order to improve implant longevity and to decrease the number of patients needing revision for aseptic osteolysis. Cite this article: Bone Joint J 2016;98-B:28–32.
A novel surgical approach for the management of giant invasive prolactinoma compressing the brainstem
Authors: Margari Niki , Pollock Jonathan , Stojanovic Nemanja 
Published: January 2016

Summary
Prolactinomas constitute the largest subsection of all secretory pituitary adenomas. Most are microprolactinomas and are satisfactorily treated by medical management alone. Giant prolactinomas, measuring more than 4 cm in diameter, are rare and usually occur more commonly in men. Macroprolatinomas tend to present with symptoms of mass effect rather than those of hyperprolactinaemia. Dopamine agonists (DA) are the treatment of choice for all prolactinomas. Surgery is usually reserved for DA resistance or if vision is threatened by the mass effects of the tumour. We describe the case of a 52 year-old woman with a giant invasive prolactinoma who required multiple surgical procedures as well as medical management with DA. One of the surgical interventions required a posterior approach via the trans cranial sub occipital transtentorial approach, a surgical technique that has not been previously described in the medical literature for this indication. The giant prolactinoma was reduced significantly with the above approach and patient symptoms from the compressing effects of the tumour were resolved. This case highlights the importance of a multidisciplinary approach to the management of such patients who present with florid neurological sequelae secondary to pressure effects. Although this presentation is uncommon, surgery via a sub occipital transtentorial approach may be considered the treatment of choice in suitable patients with giant invasive prolactinomas compressing the brainstem.

Learning points

Giant prolactinomas present with symptoms of mass effect or those of hyperprolactinaemia.

Interpretation of the pituitary profile is crucial to guide further investigations and management.

Treatment of giant invasive prolactinomas may involve a combination of medical management and multiple surgical interventions.

Treatment with DA may cause pituitary haemorrhage or infarction in patients with these tumours.

A sub occipital transtetorial approach may be considered the treatment of choice in invasive prolactinomas compressing the brainstem.

Multidisciplinary approach of such patients is fundamental for a better outcome.
Genetical Genomics of Behavior: A Novel Chicken Genomic Model for Anxiety Behavior
Authors: Johnsson Martin , Williams Michael J , Jensen Per , Wright Dominic 
Published: January 2016

AbstractThe identification of genetic variants responsible for behavioral variation is an enduring goal in biology, with wide-scale ramifications, ranging from medical research to evolutionary theory on personality syndromes. Here, we use for the first time a large-scale genetical genomics analysis in the brains of chickens to identify genes affecting anxiety as measured by an open field test. We combine quantitative trait locus (QTL) analysis in 572 individuals and expression QTL (eQTL) analysis in 129 individuals from an advanced intercross between domestic chickens and Red Junglefowl. We identify 10 putative quantitative trait genes affecting anxiety behavior. These genes were tested for an association in the mouse Heterogeneous Stock anxiety (open field) data set and human GWAS data sets for bipolar disorder, major depressive disorder, and schizophrenia. Although comparisons between species are complex, associations were observed for four of the candidate genes in mice and three of the candidate genes in humans. Using a multimodel approach we have therefore identified a number of putative quantitative trait genes affecting anxiety behavior, principally in chickens but also with some potentially translational effects as well. This study demonstrates that chickens are an excellent model organism for the genetic dissection of behavior.
PRESENT DAY TECTONIC GRADIENT IN NINH THUAN AND SURROUNDING REGION
Authors: Trinh Phan Trong , Liem Ngo Van , Hai Vy Quoc , Phong Tran Van , Huong Nguyen Van , Thuan Nguyen Viet , Xuyen Nguyen Quang , Thom Bui Van , Tuc Nguyen Dang , Vinh Hoang Quang , Thinh Nguyen Huy , Thao Bui Thi , Hung Tran Quoc 
Published: January 2016

The estimation of the present day tectonic movement and tectonic gradient (strain rate) has an important practical signification in the assessment of active fault and seismic hazards for the selection of Ninh Thuan nuclear power plant. Based on the three campaigns of GPS measurement between 2012 - 2013, we used BERNESE 5.0 software to determine present day slip rates of 13 stations in ITRF08 frame. The GPS stations move eastwards at the slip rates of 22 - 25 mm/yr, southwards at the velocities of 5 - 10 mm/yr. The standard errors in latitudinal and longitudinal directions are 1.2 mm/yr and 0.9 mm/yr, respectively. Combined with GPS data from the project of the study on actual geodynamics in Tay Nguyen TN3/06, we determined the strain rate ranging from 50 to 100 nanostrains with the standard error of 50 nanostrains. The direction of maximum compressive strain rate is from northwest - southeast to east - west.
A correspondência Jakobson-Mattoso Câmara (1945−1968)
Authors: Altman Cristina 
Published: January 2016

RESUMO:
No texto estão editadas 23 das cartas que compõem a correspondência, até então inédita, entre dois grandes autores da Linguística do século XX, Joaquim Mattoso Câmara (1904−1970) e Roman Jakobson (1896−1982), depositadas no acervo de Mattoso Câmara, na Biblioteca da Universidade Católica de Petrópolis, Rio de Janeiro, e no acervo de Roman Jakobson, confiado ao MIT Libraries-Archives and Special Collections, em Cambridge, Massachussetts.

PALAVRAS-CHAVE: Mattoso Câmara, Jakobson, estruturalismo, fonêmica
O tratamento dos pronomes pessoais átonos na gramaticografia do português (séculos XVI-XVII)
Authors: Ponce de León Romeo Rogelio 
Published: January 2016

RESUMO:
No artigo é analisada, nas obras metagramaticais do português dos séculos XVI e XVII, a descrição dos pronomes pessoais átonos. Partindo de trabalhos que, entre outros aspetos, abordam com algum pormenor o pronome na tradição gramatical do português, é estudado o grau de gramatização das formas em estudo, bem como, no caso de elas aparecerem registadas, o discurso gramatical acerca delas, tanto no que se refere à descrição como à prescrição, e os paradigmas em que se integram.

PALAVRAS-CHAVE:
Pronomes pessoais átonos – Gramaticografia do português – Séculos XVI e XVII
Assessing productivity to address safety concerns for information technology and promoting global standardization within aviation practices
Authors: Brown Willie Lee , Gilchrist Willie J. 
Published: January 2016

<p class="Els-1storder-head">Comparing these concepts with the usage of productivity assessment current design standards in implementing technological systems create concerns in safety performances [5]. The technology developmental risk was a concern in the Wright Brother era and the approach in implementing best solution practices based on simulating and testing standards to meet the goals in today’s operation is still an issue [4]. Effective modeling in promoting environmental changes for operational practices can present a risk concern in the developmental approach if productivity is not assessed [1]. Steps are needed to be taken to improve the environmental factors in the business efforts of promoting alternative energy; nonetheless, the long-term effects of not prioritizing the development standards on the global level may cause risk concerns in assessing aviation practice [1]. Realizing the sensitivity of the system development and the tradeoffs in implementing effective practices can also create awareness in the long-term efforts of environmental factors and its impact on operational cost improvements [10]. The ethical standards for human factors to improve the quality of people lives in addressing the challenges faced may be a concern going into the 21st century [7]. The tradeoffs of prioritizing can present both pros and cons; however, developmental practices are risky without modeling long-term impact and exploring different applications in adopting business practices [6]. Flexibility is an importance aspect in evaluating the productivity of long-term practices while using modern technology [6]. The productivity assessment impact in future implications and it influences to integrate traditional technology within the modern environment. </p><p> </p><p>Keywords: IT, aviation practices, promoting</p>
Advantages of using webquests in Efl Classes in A Technical University
Authors: Kuimova Marina Valeryevna , Golousenko Maksim Anatolyevich , Nikiforov Denis Sergeevich , Shcherbakov Vladislav Vladimirovich 
Published: January 2016

The main purpose of foreign language teaching is to learn to communicate and overcome the language barrier. The article studies the theoretical background of WebQuest as a valuable tool and proves that it helps learners to acquire linguistic and extra-linguistic knowledge. WebQuests ensure a context-based learning environment, help to broaden learners’ perspectives by widening ideas and concepts on different topics and acquiring creative, critical and problem-solving skills. The authors demonstrate positive outcomes of the work with WebQuest in foreign language classes at the Institute of Non-Destructive Testing, National Research Tomsk Polytechnic University. Keywords: creative skills, foreign language teaching, Internet resources, Internet technology, WebQuest
Examining the instructors computer self-efficacy perceptions
Authors: Semerci Ali , Keser Hafize 
Published: January 2016

In this study, instructors’ computer self-efficacy perceptions are examined in terms of variables such as age, gender, academic status, teaching experience, computer literacy and computer skills. The study is a descriptive one in which relational scanning method has been utilized. The study has been carried out within the framework of the data obtained from 172 police instructors who work in 28 Police Vocational Schools of Higher Education across the country. The data were collected by using a survey and “The Computer Self-efficacy Perception Scale”. A significant difference has been found between the self-efficacy perceptions of the instructors and their computer skills and computer training that they received. In addition to this, it has been seen that there was not any significant difference between self-efficacy perceptions of instructors and age, gender, position status, teaching experience and computer literacy. This is the first study carried out for determining the self-efficacy perceptions of police instructors. The results should be considered during the police trainer development trainings. Keywords: self-efficacy, self-efficacy perceptions, training, education, police education.
Modeling Study of Acid Fracture Fluid System Performance
Authors: Aljawad M. S. , Zhu D. , Hill A. D. 
Published: January 2016

Abstract
Acid fracturing stimulation can be an effective means to improve well performance in carbonate formations. In general, a treatment consists of multiple stage injections alternating between acid and non-reacting fluid to better place acid, and therefore, to create sustainable conductivity for enhanced well productivity. Selecting appropriate fluid systems is critical in success of acid fracturing. To optimize acid fracturing design, an integrated approach is needed to model the fluid behavior inside of the fracture, the conductivity after fracturing, and the productivity of fractured wells.
The integrated approach includes an acid transport model and a fracture propagation model. Theoretical models were developed to obtain the conductivity distribution and acid penetration distance inside fractures. Continuity and momentum balance equations are solved in three-dimensional space for pressure and velocity profiles. Once the velocity profile is generated, the acid balance equation can be solved for the acid concentration profile. Obtaining a concentration profile helps in calculating the amount of rock etched through diffusion and convection. Conductivity distribution is calculated using a correlation where statistical parameters are used to account for fracture heterogeneity. Finally, a reservoir simulator is used to predict the production performance from acid fractured wells.
Straight, emulsified, and gelled acid systems are examined using the integrated approach to capture the effect of each on fracture conductivity and acid penetration distance. Optimizing these two parameters will improve the production performance significantly. Straight acid reacts aggressively with carbonate formations and leaks off significantly more near the entrance of the fracture when compared with the other two acid systems. The apparent viscosities of gelled or emulsified acids are substantially higher than that of straight acid, and the diffusion coefficients of these viscous fluids are substantially lower than that of straight acid. These properties result in deeper penetration down the fracture with gelled or emulsified acids, but also less fracture etching by acid near the well. The tradeoff between deeper penetration with viscosified acid systems versus more near well etching with less viscous systems means that the acid formulation can be optimized depending primarily on the formation permeability.
Production analysis of these three acid systems suggests that emulsified acid is better used in tight formations. Gelled acid, on the other hand, results in the highest production rate when used in relatively high to medium permeability formations. Straight acid is the preferred system only when short, highly conductive fractures are desired.