bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomics in Pathology
Authors: Longuespée Rémi , Casadonte Rita , Schwamborn Kristina , Reuss David , Kazdal Daniel , Kriegsmann Katharina , von Deimling Andreas , Weichert Wilko , Schirmacher Peter , Kriegsmann Jörg , Kriegsmann Mark 
Published: December 2017

AbstractProteomic approaches are of growing importance in the biologist's toolbox. It greatly benefited from past and recent advances in sampling, chemical processing, mass spectrometry (MS) instrumentation, and data processing. MS‐based analysis of proteins is now in the process of being translated in pathology for objective diagnoses. In this viewpoint, we present the workflows that we think are the most promising for applications in pathology. We also comment what we think are prerequisites for a successful translational implementation.
Experimental and RRKM Investigations on the Degradation of Ethyl Formate
Authors: Balla Rajakumar , Muthaiah Balaganesh , Arathala Parandaman 
Published: December 2017

AbstractA Single pulse shock tube was used to investigate the thermal decomposition of ethyl formate over the temperature range of 909–1258 K and pressure range of 9–17 atm. RRKM (Rice‐Ramsperger‐Kassel‐Marcus) theory was used to estimate the temperature (500–2500 K) and pressure dependent (0.01–100 atm) rate coefficients. The products identified were methane, ethylene, and propane. The initial elementary step for the decomposition of ethyl formate is the unimolecular elimination of ethylene via the reaction CH3CH2OC(O)H → CH2=CH2 + HCOOH. The formed formic acid is further decomposed within the studied temperature range. A detailed reaction mechanism proposed with 21 species and 22 elementary reactions was used to simulate reactant and product distribution over the investigated temperature range. The temperature dependent rate coefficient for the total decomposition of ethyl formate was found to be
(909–1258 K)=2.68 × 1011 (s−1) exp (‐42.9 ± 2.2 kcal mol−1/RT). The bond dissociation energies were calculated for the various types of bonds. The calculated total rate coefficient for the thermal decomposition of ethyl formate is
(500–2500 K)=3.61 × 1013 (s−1) exp (‐53.4 kcal mol−1/RT) at high pressure limit.
The gp130 Cytokine Interleukin-11 Regulates Engraftment of Vav1–/– Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients
Authors: De Vita Serena , Li Yanhua , Harris Chad E. , McGuinness Meaghan K. , Ma Clement , Williams David A. 
Published: December 2017

Abstract
During bone marrow transplantation, hematopoietic stem and progenitor cells (HSPCs) respond to signals from the hematopoietic microenvironment by coordinately activating molecular pathways through Rho GTPases, including Rac. We have previously shown that deletion of Vav1, a hematopoietic-specific activator of Rac, compromises engraftment of transplanted adult HSPCs without affecting steady-state hematopoiesis in adult animals. Here, we show that Vav1–/– fetal HSPCs can appropriately seed hematopoietic tissues during ontogeny but cannot engraft into lethally irradiated recipients. We demonstrate that the engraftment defect of Vav1–/– HSPCs is abrogated in the absence of irradiation and demonstrate that Vav1 is critical for the response of HSPCs to the proinflammatory cytokine interleukin-11 (IL-11) that is upregulated in the marrow of irradiated recipients. Vav1–/– HSPCs display abnormal proliferative responses to IL-11 in vitro and dysregulated activation of pathways critical to engraftment of HSPCs. The engraftment of Vav1–/– HSPCs can be partially rescued in irradiated recipients treated with an anti-IL-11 antibody. These data suggest that HSPCs may respond to different functional demands by selective usage of the IL-11-Vav-Rac pathway, contextualizing further the recent view that HSPCs capable of reconstituting the blood system following transplantation might be distinct from those supporting hematopoiesis during homeostatic conditions.
Concise Review: Adaptation of the Bone Marrow Stroma in Hematopoietic Malignancies: Current Concepts and Models
Authors: Doron Ben , Handu Mithila , Kurre Peter 
Published: December 2017

Abstract
The bone marrow stroma maintains hematopoiesis and coordinately regulates regenerative responses through dynamic interactions with hematopoietic stem and progenitor cells. Recent studies indicate that stromal components in the bone marrow of leukemia patients undergo a process of successive adaptation that in turn exerts dramatic effects on the hematopoietic stem cell compartment and promotes leukemic drug resistance. Therefore, functional changes in discrete marrow stromal populations can be considered an aspect of leukemia biogenesis in that they create an aberrant, self-reinforcing microenvironment. In this review, we will describe the current understanding of the remodeling of the hematopoietic stem cell niche following invasion by leukemia cells. We place emphasis on existing evidence of how mesenchymal stem cells and their progeny facilitate neoplastic growth and describe available models and analytical techniques to understand the conversion of the niche toward disease persistence.
Interactions of the manganese hyperaccumulator Phytolacca americana L. with soil pH and phosphate
Authors: DeGroote Kara V. , McCartha Grace L. , Pollard A. Joseph 
Published: December 2017

AbstractHyperaccumulators are plants that store exceptionally high concentrations of heavy metals or metalloids in their leaves. Phytolacca americana is one of the few species known to hyperaccumulate manganese (Mn); however, it is a common weedy species and has no specific association with high‐Mn soils. Neither the mechanism by which P. americana hyperaccumulates Mn nor the ecological significance of this trait are well understood. It has recently been suggested that P. americana secretes acids into the rhizosphere as a means of acquiring phosphate, which might coincidentally increase Mn uptake. To determine whether P. americana acidifies the surrounding soil, plants were grown in rhizoboxes providing access to living roots. A thin layer of agar containing bromocresol green pH indicator dye was placed on the roots to observe color changes indicating acidification. Comparative studies showed that P. americana acidifies the rhizosphere significantly more than the non‐accumulating plant Acalypha rhomboidea. A second experiment studied whether adjustment of soil pH and phosphate affect foliar Mn concentrations of P. americana. Concentrations of Mn in leaves were highest when plants were grown in acidified soils but were significantly lower in soils that were alkaline and/or enriched with phosphate. These results suggest that Mn hyperaccumulation may be a side effect of rhizosphere acidification as a phosphorus‐acquisition mechanism, rather than an adaptation in its own right. The findings provide fundamental information about hyperaccumulator physiology and evolution, and may be relevant to attempts to utilize P. americana for phytoremediation.
A Stack-Based Ensemble Framework for Detecting Cancer MicroRNA Biomarkers
Authors: Saha Sriparna , Mitra Sayantan , Yadav Ravi Kant 
Published: December 2017

Abstract
MicroRNA (miRNA) plays vital roles in biological processes like RNA splicing and regulation of gene expression. Studies have revealed that there might be possible links between oncogenesis and expression profiles of some miRNAs, due to their differential expression between normal and tumor tissues. However, the automatic classification of miRNAs into different categories by considering the similarity of their expression values has rarely been addressed. This article proposes a solution framework for solving some real-life classification problems related to cancer, miRNA, and mRNA expression datasets. In the first stage, a multiobjective optimization based framework, non-dominated sorting genetic algorithm II, is proposed to automatically determine the appropriate classifier type, along with its suitable parameter and feature combinations, pertinent for classifying a given dataset. In the second page, a stack-based ensemble technique is employed to get a single combinatorial solution from the set of solutions obtained in the first stage. The performance of the proposed two-stage approach is evaluated on several cancer and RNA expression profile datasets. Compared to several state-of-the-art approaches for classifying different datasets, our method shows supremacy in the accuracy of classification.
A Novel Nonlinear Parameter Estimation Method of Soft Tissues
Authors: Tong Qianqian , Yuan Zhiyong , Zheng Mianlun , Liao Xiangyun , Zhu Weixu , Zhang Guian 
Published: December 2017

Abstract
The elastic parameters of soft tissues are important for medical diagnosis and virtual surgery simulation. In this study, we propose a novel nonlinear parameter estimation method for soft tissues. Firstly, an in-house data acquisition platform was used to obtain external forces and their corresponding deformation values. To provide highly precise data for estimating nonlinear parameters, the measured forces were corrected using the constructed weighted combination forecasting model based on a support vector machine (WCFM_SVM). Secondly, a tetrahedral finite element parameter estimation model was established to describe the physical characteristics of soft tissues, using the substitution parameters of Young’s modulus and Poisson’s ratio to avoid solving complicated nonlinear problems. To improve the robustness of our model and avoid poor local minima, the initial parameters solved by a linear finite element model were introduced into the parameter estimation model. Finally, a self-adapting Levenberg–Marquardt (LM) algorithm was presented, which is capable of adaptively adjusting iterative parameters to solve the established parameter estimation model. The maximum absolute error of our WCFM_SVM model was less than 0.03 Newton, resulting in more accurate forces in comparison with other correction models tested. The maximum absolute error between the calculated and measured nodal displacements was less than 1.5 mm, demonstrating that our nonlinear parameters are precise.
Loneliness, socio-economic status and quality of life in old age: the moderating role of housing tenure
Authors: SZABO AGNES , ALLEN JOANNE , ALPASS FIONA , STEPHENS CHRISTINE 
Published: December 2017

ABSTRACTThe study investigated housing tenure as a factor moderating the effects of loneliness and socio-economic status (SES) on quality of life (control and autonomy, pleasure, and self-realisation) over a two-year period for older adults. Data from the 2010 and 2012 waves of the New Zealand Health, Work, and Retirement Study were analysed. Using case-control matching, for each tenant (N = 332) we selected a home-owner (N = 332) of the same age, gender, ethnicity, SES, working status and urban/rural residence. Structural equation modelling was employed to examine the impact of SES, housing tenure and loneliness on quality of life over time. Emotional loneliness exerted a significant negative main effect on control and autonomy and pleasure. Tenure and SES influenced control and autonomy, but not pleasure or self-realisation. Tenure moderated the effect of emotional loneliness on control and autonomy, with the negative effect of emotional loneliness weaker for home-owners compared to renters. Tenure moderated the effect of SES on control and autonomy, with the positive impact of SES stronger for home-owners. Findings suggest that owners capitalise on their material and financial resources more than tenants in terms of their quality of life. In addition, home-ownership can act as a protective factor against the harmful effects of emotional loneliness in old age.
Perceptions of Quality of Life and Pollution among China's Urban Middle Class: The Case of Smog in Tangshan
Authors: Li Xiaoyue , Tilt Bryan 
Published: December 2017

AbstractAfter decades of rapid economic development, China is facing severe environmental problems. In particular, smog in urban areas has recently attracted a great deal of scientific and media attention both domestically and internationally. Our focus in this article is on public perceptions of smog in the northern city of Tangshan, which is routinely ranked as one of the urban areas with the worst air quality in the nation. In this article, we present the results of qualitative interviews and quantitative surveys with 341 urban residents. We examine how these residents perceive and weigh the importance of various aspects related to quality of life, including their experience with air pollution. Study participants considered environmental quality an issue of lower priority than many others; however, they surprisingly ranked it over economic concerns such as jobs and income. Their responses suggest that, for many urban residents, environmental problems like smog are fundamentally linked to basic quality of life concerns such as physical health and family well-being. We interpret our findings in the context of literature on the rise of China's middle class, the rise of environmental consciousness, and the role of gender in mediating perceptions of pollution and family health. We also consider the implications of these findings for the control and remediation of air pollution in China today.
Intergenerational transmission of violence: The mediating role of adolescent psychopathology symptoms
Authors: Low Sabina , Tiberio Stacey S. , Shortt Joann Wu , Mulford Carrie , Eddy J. Mark , Capaldi Deborah M. 
Published: December 2017

AbstractEvidence on the intergenerational continuity of intimate partner violence (IPV) suggests small to moderate associations between childhood exposure and young adult IPV involvement, suggesting an indirect effects model. Yet, few prospective studies have formally tested meditational mechanisms. The current study tested a prospective (over 9 years) moderated-mediational model in which adolescent psychopathology symptoms (i.e., internalizing, externalizing, and combined) mediated the association between exposure to IPV in middle childhood and young adult IPV perpetration. In a more novel contribution, we controlled for proximal young adult partner and relationship characteristics. The sample consisted ofn= 205 participants, who were, on average, assessed for exposure to parent IPV at age 12.30 years, adolescent psychopathology symptoms at age 15.77 years, and young adult IPV at 21.30 years of age. Data suggest a small, significant direct path from IPV exposure to young adult perpetration, mediated only through adolescent externalizing. Gender moderation analyses reveal differences in sensitivity to exposure across developmental periods; for males, effects of exposure were intensified during the transition to adolescence, whereas for females, effects were amplified during the transition to adulthood. In both cases, the mediational role of psychopathology symptoms was no longer significant once partner antisocial behavior was modeled. Findings have important implications for both theory and timing of risk conveyance.
Clinical efficacy and safety of switch from bosentan to macitentan in children and young adults with pulmonary arterial hypertension
Authors: Aypar Ebru , Alehan Dursun , Karagöz Tevfik , Aykan Hayrettin Hakan , Ertugrul İlker 
Published: December 2017

AbstractBackgroundMacitentan is an orally active, potent, dual endothelin receptor antagonist and is the only registered treatment for pulmonary arterial hypertension that significantly reduced morbidity and mortality in a long-term event-driven study.AimFew studies compared the clinical efficacy and safety of switch from bosentan to macitentan only in adult patients with pulmonary arterial hypertension. We aimed to evaluate the clinical efficacy and safety of switch from bosentan to macitentan in children and young adults.MethodsThis is a single-institution, 24-week prospective study. Patients ⩾12 years of age with idiopathic/heritable pulmonary arterial hypertension or related to CHD or residual pulmonary arterial hypertension due to repaired congenital systemic-to-pulmonary shunts and on bosentan therapy were included. Concomitant treatment with oral phosphodiesterase type 5 inhibitors and inhaled prostanoids was allowed. Outcome measures included change from baseline to week 24, in the 6-minute walk distance, functional class, oxygen saturation at rest/after 6-minute walk distance test, systolic pulmonary artery pressure estimated by echocardiography, and brain natriuretic peptide levels. Safety end points included adverse events laboratory abnormalities.ResultsA total of 13 patients – 5 male and 8 female – completed the study. The mean age was 20.3±6.5 years (12–35) and weight was 54.0±14.5 kg (27–75). Five patients were ⩽18 years of age. Macitentan improved 6-minute walk distance from baseline (mean: 466±35 m (300–590)), at 12 weeks (mean: 494±78 m (325–590), +28 m) (p<0.05), and at 24 weeks (mean: 507±58 m (325–625), +41 m) (p<0.05). Macitentan did not significantly change functional class, oxygen saturation at rest/after 6-minute walk distance test, brain natriuretic levels, and systolic pulmonary artery pressure (p>0.05). None of the patients had anaemia, hepatotoxicity, and peripheral oedema.ConclusionsOur study is the first study that showed that switch from bosentan to macitentan significantly improved exercise capacity in children and young adults with pulmonary arterial hypertension and is well tolerated without any adverse events.
Coronary sinus ostial atresia with persistent left superior caval vein in a patient with congenitally corrected transposition of the great arteries
Authors: Zhang Yuchen , Alberdi Hugo V. , Nguyen Elsie T. 
Published: December 2017

AbstractWe present a case of a 57-year-old man with congenitally corrected transposition of great vessels who was found to have coronary ostial atresia with cranial flow through left superior vena cava on CT with contrast injection in coronary tributaries. As such, he was ineligible for cardiac resynchronization therapy.
A Novel Design Approach for Self-Crack-Healing Structural Ceramics with 3D Networks of Healing Activator
Authors: Osada Toshio , Kamoda Kiichi , Mitome Masanori , Hara Toru , Abe Taichi , Tamagawa Yuki , Nakao Wataru , Ohmura Takahito 
Published: December 2017

AbstractSelf-crack-healing by oxidation of a pre-incorporated healing agent is an essential property of high-temperature structural ceramics for components with stringent safety requirements, such as turbine blades in aircraft engines. Here, we report a new approach for a self-healing design containing a 3D network of a healing activator, based on insight gained by clarifying the healing mechanism. We demonstrate that addition of a small amount of an activator, typically doped MnO localised on the fracture path, selected by appropriate thermodynamic calculation significantly accelerates healing by >6,000 times and significantly lowers the required reaction temperature. The activator on the fracture path exhibits rapid fracture-gap filling by generation of mobile supercooled melts, thus enabling efficient oxygen delivery to the healing agent. Furthermore, the activator promotes crystallisation of the melts and forms a mechanically strong healing oxide. We also clarified that the healing mechanism could be divided to the initial oxidation and additional two stages. Based on bone healing, we here named these stages as inflammation, repair, and remodelling stages, respectively. Our design strategy can be applied to develop new lightweight, self-healing ceramics suitable for use in high- or low-pressure turbine blades in aircraft engines.
INTEGRATE-Vis: a tool for comprehensive gene fusion visualization
Authors: Zhang Jin , Gao Teng , Maher Christopher A. 
Published: December 2017

AbstractDespite the increasing quantity of tools for accurately predicting gene fusion candidates from sequencing data, we are still faced with the critical challenge of visualizing the corresponding gene fusion products to infer their biological consequence (i.e. novel protein and increased gene expression). This is currently accomplished by manually inspecting and inferring the biological consequence of top scoring gene fusion candidates. This labor-intensive process could be made easier by automating the annotation of gene fusion products and generating easily interpretable visualizations. We developed a gene fusion visualization tool, called INTEGRATE-Vis, that generates comprehensive, highly customizable, publication-quality graphics focused on annotating each gene fusion at the transcript- and protein-level and assessing expression within an individual sample or across a patient cohort. INTEGRATE-Vis is the first comprehensive gene fusion visualization tool to help a user infer the potential consequence of a gene fusion event. It has potential utility in both research and clinical settings. INTEGRATE-Vis is available at https://github.com/ChrisMaherLab/INTEGRATE-Vis.
Effect of nanoindentation depth and ligament size on mechanical properties of nanoporous silver
Authors: Li Zhiqiang , Lu Xing , Wang Qi , Zhang Siwen 
Published: December 2017

Mechanical properties of nanoporous silver have been investigated by nanoindentation. Experiment shows that the hardness and elastic modulus are both involved with strong surface size effect. Under the same loading rate, hardness decreases from 56.7 to 26 MPa along with indentation depth increasing from 200 to 2000 nm, while the corresponding elastic modulus increases from 2.68 to 3.73 GPa. In the case of the same indentation depth, the hardness decreases from 53 to 7.4 MPa with ligament size increasing from 100 to 198 nm, and the corresponding elastic modulus reduces from 4.7 to 0.17 GPa. The calculated indentation size effect index m is 0.34, revealing that nanoporous silver has a good ductility in micro‐state, but brittle in the macro‐state.
On a Minkowski-like inequality for asymptotically flat static manifolds
Authors: McCormick Stephen 
Published: December 2017

The Minkowski inequality is a classical inequality in differential geometry giving a bound from below on the total mean curvature of a convex surface in Euclidean space, in terms of its area. Recently there has been interest in proving versions of this inequality for manifolds other than

R

n

\mathbb {R}^n

; for example, such an inequality holds for surfaces in spatial Schwarzschild and AdS-Schwarzschild manifolds. In this note, we adapt a recent analysis of Y. Wei to prove a Minkowski-like inequality for general static asymptotically flat manifolds.