bluuebunny/crossref_metadata_2025_split huggingface dataset:
Языковая репрезентация концептов маскулинности и фемининности: гендерные представления в социальной сети Твиттер
Authors: Бейсембаева A. У. , Ерофеева И.В. 
Published: September 2024

В данной статье рассматривается гендерная идентичность через призму концептов «мужчина» и «женщина» в их языковом выражении. Трансформационные изменения гендерной идентичности, демонстрирующие современное понимание представлений о мужчинах и женщинах, мы можем проследить в материалах социальных сетей, поскольку появилась возможность для человека в любой точке мира высказать свое мнение через экран монитора. Анализ микроблогов, постов и комментариев позволил прийти к выводу, что такие категории концептов как возраст, моральные качества, внешность, карьера стали по-новому рассматриваться представителями как женского, так и мужского пола. В целях карьерного роста, стремлении достичь больших высот на первое место в социуме выдвигаются новые качества успешного человека. С учетом цифровизации общества стало возможным начать свое дело для любого человека вне зависимости от его возраста, образования, внешнего вида. Текущие изменения актуализируют вопрос о гендерной идентичности и необходимости дальнейшего наблюдения, исследования и сопоставления языковых и культурных изменений, происходящих в обществе и сознании человека. Анализ языковых концептов маскулинности и фемининности позволил выявить особенности гендерных представлений обоих полов, представленных в материалах социальной сети Твиттер, а также определить современные черты гендерной идентичности. Основным методом исследования послужил метод сплошной выборки. Научная значимость исследования заключается в изучении языковой репрезентации гендерных взаимоотношений полов в разных лингвокультурах. Практическая значимость работы направлена на выявление гендерных проблем в обществе и способах их выражения посредством микроблогов. В ходе исследования отмечено, что гендерная идентичность нового поколения достаточно динамична, быстро развивается под воздействием новых вызовов тысячелетия и создает новые концептуальные ядра маскулинности и фемининности, наделяя личность актуальными чертами, способными конкурировать в межкультурном пространстве.
The oculomotor cistern and pituitary adenomas: anatomical and clinical study
Authors: Serioli Simona , Buffoli Barbara , Vezzoli Marika , Franco Caterina , Agosti Edoardo , Zattra Costanza Maria , De Maria Lucio , Mattavelli Davide , Rigante Mario , Ferrari Marco , Mattogno PierPaolo , Hirtler Lena , Rezzani Rita , Herman Philippe , Bresson Damien , Schreiber Alberto , Maroldi Roberto , Gasparotti Roberto , Gaudino Simona , Nicolai Piero , Fontanella Marco Maria , Poliani Pietro Luigi , Lauretti Liverana , Olivi Alessandro , Doglietto Francesco 
Published: September 2024

OBJECTIVE
The oculomotor cistern (OMC) is a meningeal cuff filled with CSF that contains the oculomotor nerve (cranial nerve [CN] III) at the level of the lateral wall of the cavernous sinus. Only a few studies have investigated the involvement of the OMC by pituitary adenomas (pituitary neuroendocrine tumors [PitNETs]), mainly with relatively small case series. The aim of this study was to perform a histomorphological description of the OMC and systematically analyze its involvement by PitNETs from radiological, clinical, and surgical perspectives.

METHODS
Ten hemisellae from formalin-fixed specimens were studied with 3-µm sections. Digital image analysis software was used for morphological and quantitative assessments. Clinical, radiological, surgical, and histological data of patients undergoing endoscopic transsphenoidal surgery for PitNETs at the University of Brescia, Italy, between 2014 and 2021 were recorded. OMC involvement was graded as not compressed, compressed, and invaded. The same surgical team operated on all patients.

RESULTS
The OMC had an elliptical shape with an average area of 3.1 mm2 and a length of 5.5 mm. No cisternal points of weakness were recognized in the histomorphological study.
Of 315 patients, 246 had complete data: apoplexy and CN III palsy were documented in 6.9% and 8.5%, respectively. OMC compression and invasion were recorded in 106 (43.1%) and 23 (9.3%) patients. Significant associations between OMC involvement and PitNET dimensions (p < 0.001), Knosp grade (p < 0.001), preoperative oculomotor palsy (p < 0.001), Ki-67 percentage (p = 0.009), and recurrence/progression of residual tumor (p = 0.008) were found. A new postoperative CN III palsy was evident in 2%: transient in 4 cases, and persistent in 1 patient treated for a recurrent PitNET who experienced a local infection complication. Preoperative CN III palsy improved in 10 cases.

CONCLUSIONS
Significant OMC involvement by PitNETs might be underrecognized, but it can be treated using the endoscopic transsphenoidal approach, and it affects patient outcomes.
Enhancing surgical precision: a novel electromyography finding for confident identification of the root exit zone during microvascular decompression surgery
Authors: Cho Kyung Rae , Park Soung Wook , Lee Hyun Seok , Park Sang-ku , Park Kwan 
Published: September 2024

OBJECTIVE
The lateral spread response (LSR) is an important electrophysiological sign that predicts successful decompression in patients undergoing microvascular decompression (MVD) for hemifacial spasm (HFS). However, LSRs do not consistently correlate with clinical outcomes, and there are cases in which LSRs are absent. In this study, the authors identified a unique pattern on facial nerve electromyography (EMG) when the root exit zone (REZ) is touched. This distinctive EMG pattern, which the authors coined the "Sang-ku sign" (SKS), could aid in identifying the offending vessel on the REZ, even in the absence of LSRs.

METHODS
Between November 2022 and August 2023, the authors analyzed EMG findings from 185 patients undergoing MVD for HFS. Bipolar stimulation electrodes were placed at the marginal mandibular branch, and recordings were obtained from the frontalis and orbicularis oris muscles. Additionally, stimulation electrodes were placed at the temporal branch, and recordings were obtained from the oris and mentalis muscles. The authors statistically analyzed the presence of SKS and its association with demographic, surgical, clinical outcomes, and anatomical factors.

RESULTS
The authors observed a brief, burst-like wave pattern arising from all recorded muscle branches when Teflon felt was placed between the REZ and the facial nerve. This EMG pattern, the SKS, was found in 164 patients (88.6%). Among the factors analyzed, only patient age showed a significant association with the presence of the SKS in univariate analysis (p = 0.007). The presence of the SKS was significantly associated with predicting the disappearance of LSRs (p = 0.045). Clinical outcomes were favorable (99% at the last follow-up) in all cases; thus, no positive correlation was observed in the existence of the SKS and LSRs.

CONCLUSIONS
The SKS could serve as an excellent guide for the facial nerve REZ during surgery. Given that HFS results from abnormal vascular contact on the REZ, this finding plays a crucial role in ensuring surgical success. Alongside LSRs, the SKS could provide valuable insights for neurosurgeons.
Intraoperative confocal laser endomicroscopy during 5-aminolevulinic acid–guided glioma surgery: significant considerations for resection at the tumor margin
Authors: Abramov Irakliy , Mathis Andrea M. , Xu Yuan , On Thomas J. , Belykh Evgenii , Mignucci-Jimenez Giancarlo , Hartke Joelle N. , Restelli Francesco , Pollo Bianca , Acerbi Francesco , Schucht Philippe , Porter Randall W. , Smith Kris A. , Eschbacher Jennifer M. , Preul Mark C. 
Published: September 2024

OBJECTIVE
Because gliomas have poorly defined tumor margins, the ability to achieve maximal resection is limited. To better discern these margins, fluorescence-guided surgery has been used to aid maximal safe resection. The authors describe their experience with the simultaneous use of intraoperative fluorescein sodium (FNa) confocal laser endomicroscopy (CLE) and operating microscope 5-aminolevulinic acid (5-ALA) fluorescence imaging for glioma resection to improve CLE use for better margin discrimination.

METHODS
FNa CLE and 5-ALA wide-field imaging were used in 33 patients with gliomas. CLE imaging was enhanced with the use of a telesurgical pathology software platform that enables real-time conversation between the operating neurosurgeons and the pathologists located remotely. CLE was used for imaging tumor regions that were subjectively regarded as tumor margins under normal visualization with the operative microscope. After FNa CLE imaging, 5-ALA wide-field imaging was performed in the same regions. Tissue was biopsied at imaging locations, and interpretations of FNa CLE and 5-ALA wide-field imaging were compared to those of permanent histological sections.

RESULTS
Eighty-eight deep- and superficial-margin regions of interest (ROIs) were imaged with FNa CLE and 5-ALA imaging. Most of the ROIs interpreted by the neuropathologist as infiltrative glioma based on FNa CLE imaging lacked 5-ALA–induced fluorescence. Permanent histological sections from the corresponding regions were concordant with the interpretation of FNa CLE images in 57 of 88 (65%) ROIs and with the interpretation of 5-ALA imaging in 43 of 88 (49%) ROIs. The sensitivity and specificity of FNa CLE for the interpretation of tumor margins were 73% and 41%, respectively, and those of 5-ALA were 38% and 82%, respectively. Positive and negative predictive values for CLE were 79% and 33%, respectively, and those for 5-ALA were 86% and 31%, respectively.

CONCLUSIONS
Conventional intraoperative evaluation of tumor margins, based on MRI and wide-field fluorescence imaging, can underestimate the invasiveness of gliomas. FNa CLE showed higher accuracy in detecting regions with infiltrating tumors than intraoperative 5-ALA imaging. Future considerations should include more rigorous comparisons of FNa CLE imaging and 5-ALA–guided resections on a larger cohort of patients.
F (R, Lm) ГРАВИТАЦИЯДАҒЫ КЕШ ҒАРЫШТЫҚ КЕҢЕЮДІҢ МҰЗДАТЫЛҒАН КВИНТЕССЕНЦИЯСЫН ЗЕРТТЕУ
Authors: Жадыранова А. , Исмаил У. , Бейсекеева Ж. , Бекова Г. , Уалиханова У. 
Published: September 2024

Ғарыштық кеңеюдің соңғы кезеңіндегі квинтессенциалды мұздату сценарийін сызықтық емес гравитациялық модель көмегімен зерттейміз , мұндағы α-еркін параметр. Осы модельдің шешімін сәйкес масштабты коэффициентті параметрлеуді қолдана отырып қарастырамыз, содан кейін модель CC, Pantheon+ (SN) және CC+SN+BAO сияқты бақылау деректер жиынтығымен шектеледі. Хаббл параметрі, баяулау параметрі, материя-энергия тығыздығы және біздің модельдің EoS параметрі оның физикалық жарамдылығын растай отырып, ғарыштық уақыт бойынша күтілетін тенденцияларды көрсетеді. Сонымен қатар, модель кейінгі уақытта ΛCDM моделімен үйлесімділікті көрсетеді, жазықтығында қату әрекетін және тығыздықтың бұзылуына төзімділікті көрсетеді. Нәтижелер өзгертілген гравитациялық моделі ғаламның үдеу фазасын сипаттауға сенімді тәсіл екенін көрсетеді. Соңғы уақытта әртүрлі космологиялық бақылаулар ғаламның жеделдетілген кеңеюінің дәлелдерін күшейтті. Бұл бақылауларға Ia типті суперновалар (SN Ia), ауқымды құрылым (LSS), Уилкинсон микротолқынды анизотропия зонды (WMAP), ғарыштық микротолқынды фондық сәулелену (CMBR) және бариондық акустикалық тербелістер (BAOs) арқылы жүргізілген өлшеулер жатады. Осы әртүрлі деректер жиынтығын сәйкестендіру ғаламның жеделдетілген кеңеюін басқаратын жұмбақ компонент - күңгірт энергияның (DE) бар екендігінің нақты дәлелдерін береді. Алайда, осы космологиялық бақылауларға сәйкес, DE және күңгірт материя (DM) бірге ғаламның шамамен 95-96% құрайды, бұл әлі толық түсінілмеген жұмбақ компоненттер.Керісінше, бариондық материя ғаламның жалпы көлемінің шамамен 4-5% құрайды. Қазіргі уақытта жалпы салыстырмалылық (GR) сипатталған көптеген гравитациялық эксперименттермен расталған ең сәтті гравитациялық теория болып саналады. Табысқа қарамастан, GR DE және DM жұмбақтарының қанағаттанарлық шешімін ұсына алмайды. Бұл кемшілік GR барлық заманауи космологиялық мәселелерді шешу үшін гравитация соңғы теориясы бола алмайтындығын білдіреді. Соңғы бiрнеше онжылдықта әдебиетте қазiргi космологиялық дилеммаларды шешудiң түрлi балама тәсiлдерi ұсынылды. Олардың ішінде модификацияланған гравитация теориясы ғаламдағы DE және DM байланысты мәселелерді шешуге ең перспективалы үміткер ретінде пайда болды. Ғаламның күңгірт сипаты туралы жұмбақты шешудің жетекші тәсілі GR модификациясының f (R) гравитация теориясы арқылы өзгерту болып табылады,мұндағы R-Риччи скаляры. Бұл теория Риччи скалярын жалпы функциясымен алмастыру арқылы Эйнштейн-Гильберт әрекетін өзгертуді ұсынады, бұл DE қажеттілігінсіз ғаламның жеделдетілген кеңеюін түсіндіруге негіз ұсынады. Бұл мәселені шешу үшін теориясы сияқты бірнеше басқа өзгертілген теориялар жасалды, мұндағы импульс-энергия тензорының ізін білдіреді, теориясы, мұндағы T бұралу скалярын білдіреді, теориясы, мұндағы метрикалы емес скалярды білдіреді, теориясы, мұндағы Гаусс-Боннет инвариантын білдіреді және басқалары.
Organizational Diagnosis in State Universities and Colleges (SUCs): Academic Deans’ Perspectives through the Lens of Weisbord’s Six-Box Model
Authors: Amorin Ronel 
Published: September 2024

In an increasingly complex educational landscape, the ability of Higher Education Institutions (HEIs) to maintain organizational performance and effectiveness is critical for their sustained success. Amidst evolving challenges, organizational diagnosis plays a crucial role in ensuring organizational robustness within these institutions, enabling them to navigate and thrive in the higher education sector. This descriptive-correlational study aimed at examining an organizational diagnosis based on Weisbord’s Six-Box Model in State Universities and Colleges (SUCs). The academic deans were purposively chosen as samples of the investigation. Preziosi’s (1980) organizational diagnosis questionnaire (ODQ) based on Weisbord’s Model, an adopted data-gathering instrument was used in data collection. Means and standard deviations were used for descriptive analyses while Spearman’s rho set at 0.05 alpha level was employed for inferential analyses. In all organizational aspects, the results showed that there were no significant problems or challenges. In general, there were strong interrelationships among all the internal elements in the diagnosis model. Specifically, the strongest correlation existed between purpose and structure, between leadership and structure, and purpose and leadership. There is still reason to believe that the SUCs should function more efficiently in order to reach the optimum working conditions, even though no issues or problems revealed in the model. This study provides a framework that SUC officials and administrators can utilize while conducting an organizational assessment and review, as well as a full model that can be established for long-term performance and effectiveness.
Prediction and Analysis of Rice Production and Yields Using Ensemble Learning Techniques
Authors: Sulistya Yudha Islami , Musdholifah Aina , Sapuletea Chrissandy , Br Bangun Elsi Titasari , Hamda Hizbullah , Anjani Sarah , Septiadi Abednego Dwi 
Published: September 2024

This research focuses on predicting and analyzing rice production and yield throughout the world using ensemble learning techniques. The study applies and compares three methods: linear regression, ARIMA, and ensemble learning, to predict rice harvest yields. The results show that ensemble learning techniques significantly improve prediction performance. For instance, the ensemble model for predicting area harvested, combining Model 6 (linear regression) and Model 10 (ARIMA), achieved of coefficient of determination outperforming the individual models. Similarly, for predicting yield, the ensemble model combining Model 4 (linear regression) and Model 9 (ARIMA) achieved of coefficient of determination indicating superior prediction accuracy. For predicting production, the ensemble model combining Model 2 (linear regression) and Model 8 (ARIMA) achieved of coefficient of determination. These results demonstrate the effectiveness of ensemble learning in enhancing prediction accuracy with lower MSE and RMSE values. By analyzing various factors influencing rice yields, this research provides valuable insights for increasing rice production and yield, supporting efforts to improve the efficiency and effectiveness of rice farming, and contributing to achieving the United Nations Sustainable Development Goals (SDGs).
Cardiovascular adverse events associated with targeted therapies for multiple myeloma: a pharmacovigilance study
Authors: Zhang Yanli , Shan Chang , Zhang Xinxin , Liu Ying , Xia Yunlong , Wang Yanfeng 
Published: September 2024

IntroductionMultiple myeloma (MM) is a leading cause of hematopoietic cancer-related mortality, accounting for 20% of deaths. MM-targeted therapies have demonstrated efficacy, and since 2015, the United States Food and Drug Administration (FDA) has approved five targeted drugs. However, their cardiovascular safety has not been comprehensively evaluated.ObjectiveThis study aimed to investigate the association between MM-targeted therapy and cardiovascular adverse events (AEs).MethodsDisproportionality analysis was conducted on reports from the FDA AE Reporting System database from 2014 to the second quarter of 2023. Cardiovascular AEs were grouped into nine narrow categories using the Standardized Medical Dictionary for Regulatory Activities Queries (SMQs).ResultsA total of 3,228 cardiovascular AE cases involving MM-targeted therapy were extracted and analyzed. Significant disproportionality was identified for daratumumab, elotuzumab, and isatuximab. Among the nine narrow SMQ categories, the three most reported cardiovascular AEs were cardiomyopathy, cardiac arrhythmias, and embolic and thrombotic events. Noninfectious myocarditis/pericarditis, cardiac arrhythmias, and embolic and thrombotic events exhibited the strongest signal strengths. The cardiovascular AE risk was higher within the first month and gradually decreased thereafter; however, it increased rapidly again after 1 year. This trend was observed for all cardiovascular AEs. The Kaplan–Meier curve and the log-rank test revealed that isatuximab and elotuzumab exhibited a significantly lower probability of cardiovascular AEs than daratumumab (p &lt; 0.001).ConclusionsMM-targeted therapy is significantly associated with an increased risk of previously unknown cardiovascular AE profiles, with the range and onset differing among various drugs, thereby warranting specific monitoring and appropriate management.
Efeitos da trimetazidina em pacientes com infarto agudo de miocárdio: revisão sistemática
Authors: Camacho Sebastián Alonso Hernández , Feitosa Samuel Sathler Gomes , Coquejo Tulio Ezequiel da Silveira , Andrade Paulo Victor Silveira 
Published: September 2024

Considerando que infarto agudo do miocárdio (IAM) é a condição que mais mata pessoas adultas no mundo, diversas terapias têm sido propostas para diminuir a morbidade e mortalidade desta patologia. Nesse sentido, a trimetazidina que é um medicamento anti-isquêmico, cardioprotetor e vasodilatador. Porém, ainda é incerta sua função em pacientes com IAM. Objetiva-se avaliar o impacto da trimetazidina na mortalidade, fração de ejeção ventricular (FEVE), e nos marcadores de injúria miocárdica em pacientes com IAM. Para tanto, procede-se à procura nas bases de dados da BVS, PUBMED, LILACS e IBECS artigos originais publicados entre 2011 e 2023 que abordassem o uso da trimetazidina em pacientes com IAM, e que incluíssem no mínimo um dos três desfechos citados no parágrafo anterior. Desse modo, observa-se que sete ensaios clínicos foram selecionados, totalizando 20.643 participantes. Três dos cinco estudos que abordaram o desfecho FEVE mostraram um aumento significativo deste índice após a intervenção com trimetazidina. Quatro estudos tiveram como desfecho marcadores de injúria miocárdica. Apenas um destes apontou uma redução significativa da creatinoquinase total (CK-T) e sua isoenzima MB (CK-MB) quando comparado ao grupo placebo. A morte cardíaca foi abordada por três estudos, dois deles evidenciaram redução desse índice em até 59% em um período inferior a 12 meses. Por outro lado, quando avaliado por 47,5 meses não apresentou significância estatística na redução da mortalidade. O que permite concluir que apesar da diminuição da mortalidade, melhora da FEVE pelo uso da TMZ, consideramos que estes estudos apresentam limitações como um número de amostra inadequada para o cálculo de significância estatística e tempo de seguimento.
Impacto da pandemia de COVID-19 no atendimento odontopediátrico e o uso de procedimentos minimamente evasivos no Brasil
Authors: Souza André Sobrinho de , Balbino Anne Karoliny Silva , Moraes Darah Sathler Alvim , Miyakawa Gabriela Silva , Amorim Julia Fernanda Cotta de , Balbino Kartesiany Silva , Pivetta Lariza , Milleri Daniela Pertel 
Published: September 2024

Considerando a pandemia do COVID-19 que gerou impactos diretos na área da saúde, a odontopediatria também foi afetada, uma vez que a transmissão do vírus ocorre a partir de gotículas e aerossóis de um indivíduo infectado. Desta forma foram efetivados protocolos e medidas de segurança extras antes e durante o tratamento para minimizar a propagação da infecção entre os dentistas, os pacientes e outros profissionais de saúde. No atendimento odontopediátrico alguns autores sugerem a utilização dos procedimentos minimamente invasivos (PMI´s) no manejo das lesões de cárie. Sendo assim, objetiva-se revisar a literatura sobre o impacto da pandemia COVID-19 na oferta de atendimento odontopediátrico, e a utilização de procedimentos minimamente invasivos, como alternativa de atendimento nos consultórios odontológicos. Para tanto, procede-se um estudo de revisão integrativa, no qual foi realizado um levantamento bibliográfico nas bases de dados Scielo, Lilacs, Pubmed do período 2020 a 2024. Desse modo, observa-se que a pandemia de COVID-19 causou mudanças significativas na alimentação das crianças, dificuldades de acesso aos serviços de saúde bucal, e necessidade de mudar os protocolos de atendimento odontopediátricos, vários estudos sugerem a opção por procedimentos odontológicos minimamente invasivos, que tem como vantagem a redução ou eliminação da produção dos aerossóis, com menor risco de contaminação para os profissionais, pacientes e para os responsáveis.