bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative MRI Evaluation of Tunnel placement in ACL Reconstruction
Authors: Parker David A. , Grasso Samuel , Scholes Corey , Fritsch Brett , Li Qing 
Published: May 2017

Introduction: Positioning of the graft ACL in the native footprint center is important to replicate the anatomy and function of the ACL for each individual patient. It is known that incorrect bone tunnel placement for the reconstructed ligament is a contributor to poor clinical outcomes postoperatively. Currently the success of tunnel placement is determined by training and experience of the treating surgeon and there is no universally accepted quantifiable and objective method to evaluate the execution of these decisions. The goal of this project was to develop a quantitative routine assessment to assist pre-surgical planning and also evaluate the execution of femoral and tibial bone tunnel placement in ACL reconstructed knees. Methods: The study recruited failed primary ACL reconstructed patients (N=25) who consented to undergo revision ACL reconstruction to establish the placement of the graft ACL tunnel apertures in the femur and tibia. Prior to surgery each participant underwent high resolution 3 T MRI of their injured knee and 3D models were generated through segmentation of soft and hard tissue knee structures. During surgery previous graft tunnels and prominent reference landmarks visible on MRI and arthroscopically were registered using intraoperative navigation to act as the reference standard. The placement of the tunnel apertures in the femur and tibia were measured in all three planes using a novel measurement method. Results: Preliminary result show that the measurement method can assess the placement of tunnel apertures in the femur and tibia within 0.1 – 1.0 mm of the intraoperative data, using reference landmarks identifiable in MRI and arthroscopically. Additionally, the area of the tunnel aperture, bone tunnel volume can be evaluated. Reliability and validation of the novel method is ongoing using medical imaging and intraoperative navigation to register the placement of bone tunnels in revision ACL reconstruction patients. Conclusions: Correct placement of graft ACL bone tunnels inside the native ACL footprint is critical to the outcome of ACL reconstruction. Development of an accurate reproducible method for assessment of tunnel placement relative to the anatomical footprint should provide a simple method for objectively assessing ACL reconstructions. Preliminary results of this routine assessment suggests that graft tunnel placement can be objectively assessed to assist clinicians to evaluate and improve ACL reconstruction technique and evaluation of ACL reconstruction outcomes.
Functional morphology of tarsal adhesive pads and attachment ability in ticksIxodes ricinus(Arachnida, Acari, Ixodidae)
Authors: Voigt Dagmar , Gorb Stanislav 
Published: May 2017

ABSTRACTThe presence of well-developed, elastic claws on ticks and widely pilose hosts led us to hypothesise that ticks are mostly adapted to attachment and locomotion on rough, strongly corrugated and hairy, felt-like substrates. However, by using a combination of morphological and experimental approaches, we visualised the ultrastructure of attachment devices of Ixodes ricinus and showed that this species adheres more strongly to smooth surfaces than to rough ones. Between paired, elongated, curved, elastic claws, I. ricinus bears a large, flexible, foldable adhesive pad, which represents an adaptation to adhesion on smooth surfaces. Accordingly, ticks attached strongest to glass and to surface profiles similar to those of the human skin, generating safety factors (attachment force relative to body weight) up to 534 (females). Considerably lower attachment force was found on silicone substrates and as a result of thanatosis after jolting.
MICROSTRUCTURE HYDRATION PRODUCTS BINDING COMPOSITION OBTAINED IN THE VORTEX JET MILL
Authors: Золотых  , Zolotykh Sergey , Сумской  , Sumskoy Dmitriy , Загороднюк  , Zagorodnyuk Liliya , Канева  , Kaneva Elena 
Published: May 2017

Zagorodnuk L.H., Sumy D.A., Golden S.V., Kaneva E.V.
MICROSTRUCTURE HYDRATION PRODUCTS BINDING COMPOSITION OBTAINED IN THE VORTEX JET MILL
By electron microscopy to study the microstructure of the cement stone made from Portland cement and activated binders of the compositions in the vortex jet mill. It was found that the open pores of the cement and cementitious compositions prepared using perlite fillers, always filled with tumors, at different stages of collective growth. The microstructure of cementitious compositions has a dense structure by rationally selected composition, effective use of mineral filler - perlite waste, creating additional support for the formation of the internal microstructure of the composite, mechanical activation raw mixture, allowing to obtain composites with desired properties.
The evolution of an uncemented acetabular component in alumina-on-alumina total hip arthroplasty has improved clinical outcome
Authors: García-Rey E. , Cruz-Pardos A. , García-Cimbrelo E. 
Published: May 2017

AimsTo determine the effect of a change in design of a cementless ceramic acetabular component in fixation and clinical outcome after total hip arthroplastyPatients and MethodsWe compared 342 hips (302 patients) operated between 1999 and 2005 with a relatively smooth hydroxyapatite coated acetabular component (group 1), and 337 hips (310 patients) operated between 2006 and 2011 using a similar acetabular component with a macrotexture on the entire outer surface of the component (group 2). The mean age of the patients was 53.5 (14 to 70) in group 1 and 53.0 (15 to 70) in group 2. The mean follow-up was 12.7 years (10 to 17) for group 1 and 7.2 years (4 to 10) for group 2.ResultsNo hips were revised due to complications related to bearing fracture or to stem loosening. A total of 15 acetabular components were revised for aseptic loosening in group 1 and two in group 2. The survival rate for acetabular component aseptic loosening at eight years was 96.8% (95% confidence interval (CI) 94.8 to 98.7) for group 1 and 99.2% (95% CI 98.0 to 100) for group 2. The risk for aseptic loosening of the acetabular component was higher in group 1 (p = 0.04, Hazard Ratio (HR) 4.99), dysplastic acetabula (p = 0.01, HR 4.12), components outside Lewinnek´s zone (p < 0.001, HR 6.13) and in those with a hip rotation centre distance greater than 5 mm (p = 0.005, HR 4.09).ConclusionAlumina ceramic-on-ceramic THA is an excellent option for young patients. Although newer components appeared to improve fixation, acetabular reconstruction is essential to obtain a satisfactory outcome. Cite this article: Bone Joint J 2017;99-B:749–58.
Lumbar surgery prior to total hip arthroplasty is associated with worse patient-reported outcomes
Authors: Eneqvist T. , Nemes S. , Brisby H. , Fritzell P. , Garellick G. , Rolfson O. 
Published: May 2017

AimsThe aims of this study were to describe the prevalence of previous lumbar surgery in patients who undergo total hip arthroplasty (THA) and to investigate their patient-reported outcomes (PROMs) one year post-operatively.Patients and MethodsData from the Swedish Hip Arthroplasty Register and the Swedish Spine Register gathered from 2002 to 2013 were merged to identify a group of patients who had undergone lumbar surgery before THA (n = 997) and a carefully matched one-to-one control group. We investigated differences in the one-year post-operative PROMs between the groups. Linear regression analyses were used to explore the associations between previous lumbar surgery and these PROMs following THA. The prevalence of prior lumbar surgery was calculated as the ratio of patients identified with previous lumbar surgery between 2002 and 2012, and divided by the total number of patients who underwent a THA in 2012.ResultsThe prevalence of lumbar surgery prior to THA in 2012 was 3.5% (351 of 10 082). Linear regression analyses showed an association with more pain (B = 4.35, 95% confidence interval (CI) 2.57 to 6.12), worse EuroQol (EQ)-5D index, (B = -0.089, 95% CI -0.112 to -0.066), worse EQ VAS (B = -6.75, 95% CI -8.58 to -4.92), and less satisfaction (B = 6.04, 95% CI 4.05 to 8.02).ConclusionLumbar spinal surgery prior to THA is associated with less reduction of pain, worse health-related quality of life, and less satisfaction one year after THA. This is useful information to share in the decision-making process and may help establish realistic expectations of the outcomes of THA in patients who also have previously undergone lumbar spinal surgery. Cite this article: Bone Joint J 2017;99-B:759–65.
Does the type of graft affect the outcome of revision anterior cruciate ligament reconstruction?
Authors: Grassi A. , Nitri M. , Moulton S. G. , Marcheggiani Muccioli G. M. , Bondi A. , Romagnoli M. , Zaffagnini S. 
Published: May 2017

Aims Our aim was to perform a meta-analysis of the outcomes of revision anterior cruciate ligament (ACL) reconstruction, comparing the use of different types of graft. Materials and Methods A search was performed of Medline and Pubmed using the terms “Anterior Cruciate Ligament” and “ACL” combined with “revision”, “re-operation” and “failure”. Only studies that reported the outcome at a minimum follow-up of two years were included. Two authors reviewed the papers, and outcomes were subdivided into autograft and allograft. Autograft was subdivided into hamstring (HS) and bone-patellar tendon-bone (BPTB). Subjective and objective outcome measures were analysed and odds ratios with confidence intervals were calculated. Results A total of 32 studies met the inclusion criteria. Five studies used HS autografts, eight reported using BPTB autografts, two used quadriceps tendon autografts and eight used various types. Seven studies reported using allografts, while the two remaining used both BPTB autografts and allografts. Overall, 1192 patients with a mean age of 28.7 years (22.5 to 39) and a mean follow-up of 5.4 years (2.0 to 9.6) were treated with autografts, while 269 patients with a mean age of 28.4 years (25 to 34.6) and a mean follow-up of 4.0 years (2.3 to 6.0) were treated with allografts. Regarding allografts, irradiation with 2.5 mrad was used in two studies while the graft was not irradiated in the seven remaining studies. Reconstructions following the use of autografts had better outcomes than those using allograft with respect to laxity, measured by KT-1000/2000 (MEDmetric Corporation) and the rates of complications and re-operations. Those following the use of allografts had better mean Lysholm and Tegner activity scores compared with autografts. If irradiated allografts were excluded from the analysis, outcomes no longer differed between the use of autografts and allografts. Comparing the types of autograft, all outcomes were similar except for HS grafts which had better International Knee Documentation Committee scores compared with BPTB grafts. Conclusion Autografts had better outcomes than allografts in revision ACL reconstruction, with lower post-operative laxity and rates of complications and re-operations. However, after excluding irradiated allografts, outcomes were similar between autografts and allografts. Overall, the choice of graft at revision ACL reconstruction should be on an individual basis considering, for instance, the preferred technique of the surgeon, whether a combined reconstruction is required, the type of graft that was previously used, whether the tunnels are enlarged and the availability of allograft. Cite this article: Bone Joint J 2017;99-B:714–23.
Nematodes gastrointestinales en la recría bovina de la región del Chaco Serrano del noroeste de Argentina
Authors: SUAREZ Victor H. , MARTINEZ Gabriela M. , VIÑABAL Alberto E. 
Published: May 2017

El objetivo del presente trabajo fue estudiar la epidemiología de los nematodes gastrointestinales (NGI) en la recría bovina en la región del Chaco Serrano del Noroeste Argentino durante los períodos mayo-sept. 2014 y mayo-marzo 2015-16. En cada período se formaron tres grupos de 17 terneras de destete: GTS con tratamiento cada 45-50 días con moxidectina, GTL con 1 solo tratamiento: 6/2014 ivermectina y 7/2015 doramectina y GST sin tratamiento. Se realizaron conteos de huevos (hpg) y coprocultivos y se registró la ganancia de peso vivo (GPV). Al inicio en ambos períodos los hpg fueron moderados (=515±449, 2014; =484±464, 2015) elevándose hacia fines del otoño, para luego descender hacia la primavera. Los hpg del GTL mostraron postratamiento solo un descenso parcial y el GTS siempre tuvo valores de hpg muy bajos. Los géneros de nematodes predominantes fueron Cooperia (41,8%), y Haemonchus (53,7%). En ambos períodos el efecto de los tratamientos se evidenció desde el invierno, mostrando el GTS una mayor GPV (p<0,05) que la de los otros dos grupos cuando se mejoró la oferta alimenticia. Las GPV totales del GTS fueron mayores. Al final del ensayo, los promedios en la GPV fueron en kg de 11,2, 11,5 y 19,6 (2014) y de 54,3, 56,5 y 73,4 (2015-16) respectivamente para el GST, GTL y el GTS.
In vitro expansion of mouse primordial germ cell‐like cells recapitulates an epigenetic blank slate
Authors: Ohta Hiroshi , Kurimoto Kazuki , Okamoto Ikuhiro , Nakamura Tomonori , Yabuta Yukihiro , Miyauchi Hidetaka , Yamamoto Takuya , Okuno Yukiko , Hagiwara Masatoshi , Shirane Kenjiro , Sasaki Hiroyuki , Saitou Mitinori 
Published: May 2017

AbstractThe expansion of primordial germ cells (PGCs), the precursors for the oocytes and spermatozoa, is a key challenge in reproductive biology/medicine. Using a chemical screening exploiting PGC‐like cells (PGCLCs) induced from mouse embryonic stem cells (ESCs), we here identify key signaling pathways critical for PGCLC proliferation. We show that the combinatorial application of Forskolin and Rolipram, which stimulate cAMP signaling via different mechanisms, expands PGCLCs up to ~50‐fold in culture. The expanded PGCLCs maintain robust capacity for spermatogenesis, rescuing the fertility of infertile mice. Strikingly, during expansion, PGCLCs comprehensively erase their DNA methylome, including parental imprints, in a manner that precisely recapitulates genome‐wide DNA demethylation in gonadal germ cells, while essentially maintaining their identity as sexually uncommitted PGCs, apparently through appropriate histone modifications. By establishing a paradigm for PGCLC expansion, our system reconstitutes the epigenetic “blank slate” of the germ line, an immediate precursory state for sexually dimorphic differentiation.
Esophageal Adenocarcinoma with Enteroblastic Differentiation Arising in Ectopic Gastric Mucosa in the Cervical Esophagus: a Case Report and Literature Review
Authors: Gushima Ryosuke , Narita Rei , Shono Takashi , Naoe Hideaki , Yao Takashi , Sasaki Yutaka 
Published: May 2017

Background: Adenocarcinoma with enteroblastic differentiation is a subtype of alpha-fetoprotein (AFP) producing adenocarcinoma. This type of tumor is associated with a poor prognosis and is prone to metastasize. Esophageal adenocarcinoma with enteroblastic differentiation is extremely rare.Case presentation: The patient was a 65-year-old woman who was referred to our hospital with dysphagia. Endoscopic examination revealed an elevated lesion 20mm in diameter at 17cm from the upper incisors. Endoscopic submucosa dissection (ESD) was performed and histopathological examination revealed tubular adenocarcinoma composed of cuboidal cells with clear cell cytoplasm. Immunohistochemical stain was diffusely positive for Sall-like protein 4 (SALL4) and weakly positive for AFP and glypican 3. From this result, we diagnosed esophageal adenocarcinoma with enteroblastic differentiation. The patient is still alive without recurrence of cancer 40 months after ESD.Conclusion: To our knowledge, this is the first report to undergo ESD for esophageal adenocarcinoma with enteroblastic differentiation arising from ectopic gastric mucosa in the esophagus.Abbreviations: AFP: alfa-fetoprotein; CA19-9: carbohydrate antigen 19-9; CEA: carcinoembryonic antigen; ESD: endoscopic submucosal dissection; EUS: endoscopic ultrasound; FDG-PET: [18F] fluorodeoxyglucose positron emission tomography; ME: magnifying endoscopy; NBI: narrow band imaging; SALL 4: Sall-like protein 4; SCC: squamous cell carcinoma antigen.
Position Paper on Treatment of Hepatitis C in Romania, 2017. Part One
Authors: Gheorghe Liana , Sporea Ioan , Iacob Speranţa , Şirli Roxana , Trifan Anca , Dobru Daniela , Diculescu Mircea , Stanciu Carol , Pascu Oliviu , Acalovschi Monica , Brisc Ciprian , Cijevschi Cristina , Gheorghe Cristian , Spârchez Zeno , Rogoveanu Ion , Dumitrascu Dan 
Published: May 2017

Background & Aims: Hepatitis C Virus (HCV) infection is a common condition with endemic prevalence in some areas of the world. In Romania, the mean prevalence is about 3%. New treatments became available on the market in recent years and new drugs are in the pipeline. A re-evaluation of HCV therapy was considered mandatory. The Romanian Society of Gastroenterology and Hepatology undertook this task for the practitioners of this country.Methodology: A group of recognized experts was created who screened the available literature and the major available guidelines. A list of items requiring attention has been created. These items were discussed and rated. Decisions were taken by consensus.Recommendations: We present here the first of the two parts of our Society’s recommendations for chronic HCV infection treatment. An agreement was reached regarding the diagnostic tools, the assessment of severity and the up-dated therapy schedules.Conclusions: This Position Paper represents a guide for the assessment and the therapy of HCV infection. The recommendations are in concordance with other guidelines but are applied to the real-life conditions in this country.Abbreviations: DAAs: Direct-acting antivirals; DDIs: Drug-drug interactions; ESLD: End-stage liver disease; ESRD: End-stage renal disease; eGFR: Estimated glomerular filtration rate; EASL: European Association for the Study of the Liver; EMA: European Medicines Agency; FDA: US Food and Drug Administration; FDC: Fixed-dose combination; GT: Genotype; GRADE: Grading of Recommendations Assessment, Development and Evaluation; HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma; LT: Liver transplantation; LLD: Lower limit of detection; MELD score: Mayo-Clinic End-Stage Liver Disease score; ANMDM: National Agency of Medicines and Medical Devices; PPIs: Proton pump inhibitors; PWID: People who inject drugs; RCT: Randomized controlled trial; RDT: Rapid diagnostic test; RAS: Resistance-associated substitution; SRGH: Romanian Society of Gastroenterology and Hepatology; SAE: serious adverse events; SPC: Summary of Product Characteristics; SVR: Sustained virologic response.
Chorioamnionitis in the Development of Cerebral Palsy: A Meta-analysis and Systematic Review
Authors: Shi Zhongjie , Ma Lin , Luo Kehuan , Bajaj Monika , Chawla Sanjay , Natarajan Girija , Hagberg Henrik , Tan Sidhartha 
Published: May 2017

CONTEXT:Chorioamnionitis (CA) has often been linked etiologically to cerebral palsy (CP).OBJECTIVES:To differentiate association from risk of CA in the development of CP.DATA SOURCES:PubMed, Cochrane Library, Embase, and bibliographies of original studies were searched by using the keywords (chorioamnionitis) AND ((cerebral palsy) OR brain).STUDY SELECTION:Included studies had to have: (1) controls, (2) criteria for diagnoses, and (3) neurologic follow-up. Studies were categorized based on: (1) finding incidence of CP in a CA population, or risk of CP; and (2) incidence of CA in CP or association with CP.DATA EXTRACTION:Two reviewers independently verified study inclusion and extracted data.RESULTS:Seventeen studies (125 256 CA patients and 5 994 722 controls) reported CP in CA. There was significantly increased CP inpreterm histologic chorioamnionitis (HCA; risk ratio [RR] = 1.34, P &lt; .01), but not in clinical CA (CCA). Twenty-two studies (2513 CP patients and 8135 controls) reported CA in CP. There was increased CCA (RR = 1.43, P &lt; .01), but no increase in HCA in preterm CP. Increased HCA was found (RR = 4.26, P &lt; .05), as well as CCA in term/near-term CP (RR = 3.06, P &lt; .01).CONCLUSIONS:The evidence for a causal or associative role of CA in CP is weak. Preterm HCA may be a risk factor for CP, whereas CCA is not. An association with term and preterm CP was found for CCA, but only with term CP for HCA.
Cesarean Delivery and Body Mass Index at 6 Months and Into Childhood
Authors: Vinding Rebecca Kofod , Sejersen Tobias Steen , Chawes Bo L. , Bønnelykke Klaus , Buhl Thora , Bisgaard Hans , Stokholm Jakob 
Published: May 2017

BACKGROUND AND OBJECTIVES:
The prevalence of cesarean delivery (CD) is rising worldwide, and so is childhood obesity. Studies have shown associations between these factors. We examined the development of BMI from birth through childhood to determine whether CDs were associated with differences in growth and obesity.

METHODS:
Term children from the birth cohorts Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) and COPSAC2010 were included. Height, length, and weight measurements were collected prospectively until 5 years in COPSAC2010 and until 13 years in COPSAC2000. Dual-energy x-ray absorptiometry (DXA) scans were performed at 3.5 and 7 years. Information on relevant covariates were verified during clinical visits. Analyses were adjusted for covariates associating with CD.

RESULTS:
In COPSAC2010, 20% (N = 138/673) of the children were delivered by CD; 49% were girls. In COPSAC2000, 19% (N = 76/393) were delivered by CD; 51% were girls. Children delivered by CD had a higher mean BMI at 6 months compared with those delivered vaginally: COPSAC2010 β-coefficient, .41 (95% confidence interval [CI], .12 to .69), P = .01; COPSAC2000 β-coefficient, .16 (95% CI, −.11 to .68), P = .16; and meta-analysis β-coefficient, .37 (95% CI, .14 to .60), P = .002. There were no differences in BMI trajectory between the 2 groups by 5 and 13 years, nor cross-sectional BMI at 5 and 13 years, nor in fat percentages from DXA scans.

CONCLUSIONS:
Children delivered by CD had a higher BMI at 6 months of age, but this difference did not track into later childhood. Our study does not support the hypothesis that CD leads to later overweight.
Pesquisas sobre a formação matemática de professores para os anos iniciais do ensino fundamental
Authors: Szymanski Maria Lidia Sica , Martins Josiane Bernini Jorente 
Published: May 2017

O presente artigo objetiva responder à questão: “O que revelam as pesquisas sobre a formação matemática dos professores dos anos iniciais do ensino fundamental?”. Com esse intuito, realizou-se uma pesquisa bibliográfica na Biblioteca Digital de Teses e Dissertações – BDTD, no período de 2004 a 2014. Utilizou-se a Análise de Conteúdo (Bardin) para examinar títulos, palavras-chave, resumos, objetos de estudo, procedimentos metodológicos e resultados. As pesquisas apontam lacunas na formação matemática desses professores. Além de políticas públicas que amparem os processos de formação inicial e continuada, recomendam-se aquelas que promovam a aprendizagem na educação básica, contribuindo para que os alunos cheguem à universidade com os conhecimentos matemáticos fundamentais.