bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous Surface Generation and Interior Amplification of Internal Waves in a Regional-Scale Ocean Model
Authors: Shakespeare Callum J. , Hogg Andrew McC. 
Published: February 2017

AbstractRecent theories, models, and observations have suggested the presence of significant spontaneous internal wave generation at density fronts near the ocean surface. Spontaneous generation is the emission of waves by unbalanced, large Rossby number flows in the absence of direct forcing. Here, spontaneous generation is investigated in a zonally reentrant channel model using parameter values typical of the Southern Ocean. The model is carefully equilibrated to obtain a steady-state wave field for which a closed energy budget is formulated. There are two main results: First, waves are spontaneously generated at sharp fronts in the top 50 m of the model. The magnitude of the energy flux to the wave field at these fronts is comparable to that from other mechanisms of wave generation. Second, the surface-generated wave field is amplified in the model interior through interaction with horizontal density gradients within the main zonal current. The magnitude of the mean-to-wave conversion in the model interior is comparable to recent observational estimates and is the dominant source of wave energy in the model, exceeding the initial spontaneous generation. This second result suggests that internal amplification of the wave field may contribute to the ocean’s internal wave energy budget at a rate commensurate with known generation mechanisms.
Turbulent Upper-Ocean Mixing Affected by Meltwater Layers during Arctic Summer
Authors: Randelhoff Achim , Fer Ilker , Sundfjord Arild 
Published: February 2017

AbstractEvery summer, intense sea ice melt around the margins of the Arctic pack ice leads to a stratified surface layer, potentially without a traditional surface mixed layer. The associated strengthening of near-surface stratification has important consequences for the redistribution of near-inertial energy, ice–ocean heat fluxes, and vertical replenishment of nutrients required for biological growth. The authors describe the vertical structure of meltwater layers and quantify their seasonal evolution and their effect on turbulent mixing in the oceanic boundary layer by analyzing more than 450 vertical profiles of velocity microstructure in the seasonal ice zone north of Svalbard. The vertical structure of the density profiles can be summarized by an equivalent mixed layer depth hBD, which scales with the depth of the seasonal stratification. As the season progresses and melt rates increase, hBD shoals following a robust pattern, implying stronger vertical stratification, weaker vertical eddy diffusivity, and reduced vertical extent of the mixing layer, which is bounded by hBD. Through most of the seasonal pycnocline, the vertical eddy diffusivity scales inversely with buoyancy frequency (Kρ ∝ N−1). The presence of mobile sea ice alters the magnitude and vertical structure of turbulent mixing primarily through stronger and shallower stratification, and thus vertical eddy diffusivity is greatly reduced under sea ice. This study uses these results to develop a quantitative model of surface layer turbulent mixing during Arctic summer and discuss the impacts of a changing sea ice cover.
Australian experiments in creative governance, regionalism, and plurilateralism
Authors: Rimmer Susan Harris 
Published: February 2017

The previous Abbott government had prioritized a general attitude to foreign policy captured by the phrase “Jakarta not Geneva,” which signified a preference for bilateral or minilateral interactions with the region rather than United Nations-based multilateralism. With Julie Bishop MP as Australia’s first female foreign minister, the Coalition also prioritized economic diplomacy, as exemplified by the repeated refrain that Australia is “open for business.” This approach led to a preference for diplomatic venues and processes that focused on continuing investments in regional architecture, new emphasis on minilateral dialogues such as the Indian Ocean Rim Association (IORA) and Mexico, Indonesia, Korea, Turkey, and Australia (MIKTA), and more effort directed to bilateral and plurilateral processes such as the Trans-Pacific Partnership trade negotiations. This approach has been continued under Prime Minister Turnbull, with a renewed focus on innovation. Part 1 considers minilateral and regional investments in the Indo-Pacific region, primarily, IORA, the Asia-Pacific Economic Cooperation (APEC), and the Association of South East Asian Nations (ASEAN). I consider MIKTA a unique vehicle for Australian diplomacy. Part 2 considers what issues Australia should be pursuing through these forums, with a focus on the two themes of gender equality (as an example of niche diplomacy) and trade (multilateralism under pressure) as case studies. Beeson and Higgott argue that middle powers have the potential to successfully implement “games of skill,” especially at moments of international transition. How skilful have Australia’s efforts been in these minilateral dialogues, enhanced regionalism, and plurilateral processes, and what more can be achieved in these forums? Are these efforts creating more fragmentation of the rules-based order, or are they a way to overcome global governance stalemates? I set out the arguments for whether Australia, as a pivotal power, should generate more global options, or be more focused on inclusion in the Asia-Pacific region.
Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of 15O-gas in mice with bilateral common carotid artery stenosis
Authors: Temma Takashi , Yamazaki Makoto , Miyanohara Jun , Shirakawa Hisashi , Kondo Naoya , Koshino Kazuhiro , Kaneko Shuji , Iida Hidehiro 
Published: February 2017

Positron emission tomography with 15O-labeled gases (15O-PET) is important for in vivo measurement of cerebral oxygen metabolism both in clinical and basic settings. However, there are currently no reports concerning 15O-PET in mice. Here, we developed an 15O-PET method applicable to mice with spontaneous respiration of 15O-gas without a tracheotomy catheter. Sequential 15O-PET was also performed in a mouse model of chronic cerebral hypoperfusion with bilateral common carotid artery stenosis (BCAS) induced by placement of microcoils. 15O-gas with isoflurane was supplied to the nose of mouse with evacuation of excess 15O-gas surrounding the body. 15O-PET was performed on days 3, 7, 14, 21, and 28 after surgery. Cerebral blood flow (CBF), cerebral blood volume, oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2) were calculated in whole brains. A significant decrease in CBF and compensatory increase in OEF in the BCAS group produced CMRO2 values comparable to that of the sham group at three days post-operation. Although CBF and OEF in the BCAS group gradually recovered over the first 28 days, the CMRO2 showed a gradual decrease to 68% of sham values at 28 days post-operation. In conclusion, we successfully developed a noninvasive 15O-PET method for mice.
Unused Opioid Pills After Outpatient Shoulder Surgeries Given Current Perioperative Prescribing Habits
Authors: Kumar Kanupriya , Gulotta Lawrence V. , Dines Joshua S. , Allen Answorth A. , Cheng Jennifer , Fields Kara G. , YaDeau Jacques T. , Wu Christopher L. 
Published: February 2017

Background: In the past 16 years, the number of prescription opioids sold in the United States, as well as deaths from prescription opioids, has nearly quadrupled. However, the overall amount of pain reported by patients has not changed significantly. Specific information about opioid prescriptions in the perioperative period is lacking. Of the studies that have been published, investigators have shown that the majority of patients have unused postoperative opioid pills. Moreover, patients appear to lack information about disposal of unused opioid pills. Purpose: To compare the number of pills prescribed versus the numbers left unused after outpatient shoulder surgeries at an orthopaedic surgery institution. Study Design: Case series; Level of evidence, 4. Methods: In this prospective, observational study, 100 patients (age >18 years) undergoing outpatient shoulder surgery (rotator cuff repair, labral repair, stabilization/Bankart repair, debridement) were enrolled. Follow-ups were conducted via surveys on postoperative days (PODs) 7, 14, 28, and 90. The primary outcome was the number of unused pills from the originally prescribed medication. Results: For all procedure types, the median (Q1, Q3) number of prescribed pills was 60 (40, 80). On POD 90, patients reported a median (Q1, Q3) of 13 (0, 32) unused pills; patients who underwent rotator cuff repairs had the lowest number of pills remaining (median [Q1, Q3], 0 [0, 16]), whereas patients who had stabilization/Bankart repairs had the highest number of unused pills (median [Q1, Q3], 37 [29, 50]). Patient satisfaction with pain management ranged from an average of 70% to 90%. Only 25 patients received instructions or education about opioid disposal. Conclusion: Most outpatient shoulder surgery patients who underwent certain operations were prescribed more opioid analgesics than they consumed. Patient education regarding the disposal of opioids was lacking.
In vivo and in vitro assessment of the biocompatibility and degradation of high-purity Mg anastomotic staples
Authors: Qu Su , Xia Jiazeng , Yan Jun , Wu Hongliu , Wang Hao , Yi Yi , Zhang Xiaonong , Zhang Shaoxiang , Zhao ChangLi , Chen Yigang 
Published: February 2017

Titanium (Ti) staples are not biodegradable, and anastomotic complications related to Ti staples are reported frequently. In the present study, the biocompatibility and degradation behavior of high-purity magnesium (HP Mg) staples with the small intestine were investigated. HP Mg staples did not affect the relative growth rate, cell cycle and apoptosis of primary rectal mucosal epithelial cells (IEC-6) in vitro. At one, two and three days after immersion in intestinal juice, the weight of the 30 rinsed HP Mg staples reduced by 7.5 ± 1.6, 10.6 ± 2.2 and 13.5 ± 2.1 mg, respectively, and those in the Hanks’ solution reduced by 3.9 ± 0.8, 6.1 ± 1.2 and 7.1 ± 2.4 mg. Extracts of HP Mg staples were bio-safe for IEC-6, and the corrosion rate of HP staples was faster in the small intestinal juice than in the Hanks’ solution. In the in vivo experiments, the small intestine of the minipigs was anastomosed by HP Mg and Ti staples. HP Mg staples neither affected important bio-chemical parameters nor induced serious inflammation or necrosis in the anastomosis tissues. The residual weight of a HP Mg staples (0.81 ± 0.13 mg) was 89.7% of the original weight (9 ± 0.09 mg) one month after surgery. The in vivo corrosion rate for one HP Mg staple was determined to be∼0.007 ± 0.001 mm·month−1. The preliminary results of the biocompatibility and degradation of high-purity Mg anastomotic staples are promising, and further studies will be initiated to study in more detail.
Featured Article: Chemotherapeutic delivery using pH-responsive, affinity-based release
Authors: Cyphert Erika L , Fu Andrew S , von Recum Horst A 
Published: February 2017

Doxorubicin is a chemotherapeutic drug typically administered systemically which frequently leads to cardiac and hepatic toxicities. Local delivery to a tumor has a chance to mitigate some of these toxicities and can further be mitigated by including a means of tumor-specific drug release. Our laboratory has explored the use of molecular interactions to control the rate of drug release beyond that capable of diffusion alone. To this system, we added an additional affinity group (adamantane) to doxorubicin through a pH-sensitive hydrazone bond. The result was a modified doxorubicin which had an even higher affinity to our drug delivery polymer, and virtually no release in normal conditions, but showed accelerated release of drug in tumor-like low pH. Further, we show that adamantane-modified doxorubicin (adamantane-doxorubicin) and cleaved adamantane-doxorubicin showed equivalent capacity to kill human U-87 glioblastoma cells in vitro as unmodified doxorubicin. Taken together, these data demonstrate our ability to load high levels of modified chemotherapeutic drugs into our affinity-based delivery platform and deliver these drugs almost exclusively in the acidic microenvironments, such as those surrounding the tumor tissue via pH-cleavable bond while minimizing drug delivery in neutral pH tissue, with the ultimate goal of reducing systemic through better local delivery.Impact statementDoxorubicin (DOX) is especially cytotoxic to the heart, liver, kidneys, and healthy tissues surrounding the tumor microenvironment. This systemic toxicity can be partially addressed by local, tumor-specific drug delivery systems. While pH-sensitive DOX delivery systems have been developed by several other groups, many lack a prolonged and consistent release profile required to successfully treat heterogeneous tumors. Our system of a chemically modified form of DOX combined with an affinity-based cyclodextrin delivery system is capable of delivering DOX for 87 days while maintaining its the drug cytotoxicity. This finding is particularly relevant to improving cancer treatments because it enables regulated local delivery of DOX specifically to tumor tissue and allows the drug to be continuously delivered over a therapeutically relevant amount of time.
Arterial–ventricular coupling and parameters of vascular stiffness in hypertensive patients: Role of gender
Authors: Faconti Luca , Bruno Rosa Maria , Buralli Simona , Barzacchi Marta , Dal Canto Elisa , Ghiadoni Lorenzo , Taddei Stefano 
Published: February 2017

Objective Non-invasive estimation of arterial–ventricular coupling has been extensively used for the evaluation of cardiovascular performance, however, a relative small amount of data is available regarding arterial–ventricular coupling and its components in hypertension. The present study was designed to investigate the relationship between left ventricular elastance, arterial elastance, parameters of vascular stiffness and the influence of gender in a population of hypertensive individuals. Methods In 102 patients, trans-thoracic cardiac ultrasound, parameters of aortic stiffness (carotid-femoral pulse wave velocity) and wave reflection (augmentation index) were recorded. Ultrasound images of common carotid arteries were acquired for the assessment of intima-media thickness as well as carotid compliance and distensibility coefficient. Results Mean age was 61 years, 32% diabetes, 56% dyslipidemia, 9% previous cardiovascular events; women (n = 32) and men were superimposable for cardiovascular risk factors prevalence. In the population, ventricular elastance was significantly correlated with arterial elastance (r = 0.887), age (r = 0.334), gender (r = −0.494), BMI (r = −0.313), augmentation index (r = 0.479) (all p < 0.001); and with carotid compliance and distensibility coefficient (r = 0.229 and r = − 0.250, respectively, both p < 0.05); however, only arterial elastance and gender were independently associated with ventricular elastance in multiple regression models adjusted for confounding factors. Gender-specific analysis revealed that arterial elastance and augmentation index remained statistically significant associated with ventricular elastance in men (r = 0.275, p = 0.04); instead augmentation index was no longer significant (r = 0.052, p = 0.77) in the female sex. Conclusions In hypertensive patients, main determinants of ventricular elastance are arterial elastance, as an integrated index of arterial vascular load, and gender; however, pressure augmentation might play an additional role in men.
Next generation sequencing analysis of patients with familial cervical artery dissection
Authors: Grond-Ginsbach Caspar , Brandt Tobias , Kloss Manja , Aksay Suna Su , Lyrer Philipp , Traenka Christopher , Erhart Philipp , Martin Juan Jose , Altintas Ayse , Siva Aksel , de Freitas Gabriel R , Thie Andreas , Machetanz Jochen , Baumgartner Ralf W , Dichgans Martin , Engelter Stefan T 
Published: February 2017

Background The cause of cervical artery dissection is not well understood. We test the hypothesis that mutations in genes associated with known arterial connective tissue disorders are enriched in patients with familial cervical artery dissection. Patients and methods Patient duos from nine pedigrees with familial cervical artery dissection were analyzed by whole exome sequencing. Single nucleotide variants in a panel of 11 candidate genes (ACTA2, MYH11, FBN1, TGFBR1, TGFBR2, TGFB2, COL3A1, COL4A1, SMAD3, MYLK and SLC2A10) were prioritized according to functionality (stop-loss, nonsense, and missense variants with polyphen-2 score ≥0.95). Variants classified as “benign” or “likely benign” in the ClinVar database were excluded from further analysis. For comparison, non-benign stop-loss, nonsense and missense variants with polyphen-2 score ≥0.95 in the same panel of candidate genes were identified in the European non-Finnish population of the ExAC database ( n = 33,370). Results Non-benign Single nucleotide variants in both affected patients were identified in four of the nine cervical artery dissection families (COL3A1; Gly324Ser, FBN1: Arg2554Trp, COL4A1: Pro116Leu, and TGFBR2: Ala292Thr) yielding an allele frequency of 22.2% (4/18). In the comparison group, 1782 variants were present in 33,370 subjects from the ExAC database (allele frequency: 1782/66,740 = 2.7%; p = 0.0008; odds ratio = 14.2; 95% confidence interval = 3.8–52.9). Conclusion Cervical artery dissection families showed enrichment for non-benign variants in genes associated with arterial connective tissue disorders. The observation that findings differed across families indicates genetic heterogeneity of familial cervical artery dissection.
A learned sparseness and IGMRF-based regularization framework for dense disparity estimation using unsupervised feature learning
Authors: Nahar Sonam , Joshi Manjunath V. 
Published: February 2017

Abstract
In this work, we propose a new approach for dense disparity estimation in a global energy minimization framework. We propose to use a feature matching cost which is defined using the learned hierarchical features of given left and right stereo images and we combine it with the pixel-based intensity matching cost in our energy function. Hierarchical features are learned using the deep deconvolutional network which is trained in an unsupervised way using a database consisting of large number of stereo images. In order to perform the regularization, we propose to use the inhomogeneous Gaussian Markov random field (IGMRF) and sparsity priors in our energy function. A sparse autoencoder-based approach is proposed for learning and inferring the sparse representation of disparities. The IGMRF prior captures the smoothness as well as preserves sharp discontinuities while the sparsity prior captures the sparseness in the disparity map. Finally, an iterative two-phase algorithm is proposed to estimate the dense disparity map where in phase one, sparse representation of disparities are inferred from the trained sparse autoencoder, and IGMRF parameters are computed, keeping the disparity map fixed and in phase two, the disparity map is refined by minimizing the energy function using graph cuts, with other parameters fixed. Experimental results on the Middlebury stereo benchmarks demonstrate the effectiveness of the proposed approach.
The clinical evidence for targeting human myeloid-derived suppressor cells in cancer patients
Authors: Tobin Richard P , Davis Dana , Jordan Kimberly R , McCarter Martin D 
Published: February 2017

Abstract
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that represent a formidable obstacle to the successful treatment of cancer. Patients with high frequencies of MDSCs have significantly decreased progression-free survival (PFS) and overall survival (OS). Whereas there is experimental evidence that the reduction of the number and/or suppressive function of MDSCs in mice improves the efficacy of anti-cancer therapies, there is notably less evidence for this therapeutic strategy in human clinical trials. Here, we discuss currently available data concerning MDSCs from human clinical trials and explore the evidence that targeting MDSCs may improve the efficacy of cancer therapies.
Pay Harmony? Social Comparison and Performance Compensation in Multibusiness Firms
Authors: Gartenberg Claudine , Wulf Julie 
Published: February 2017

Our study presents evidence that social comparison influences both the level of pay and the degree of performance sensitivity within firms. We report pay patterns among division managers of large, multibusiness firms over a 14-year period. These patterns are consistent with employees comparing pay against both their peers (horizontal comparison) and the chief executive officer (vertical comparison) within their firm. Horizontal comparison also appears to reduce pay–performance sensitivity, in accord with prior theory proposing that performance pay can lead to perceived pay inequity among employees. Taken together, our evidence suggests that agency costs and social comparison jointly influence pay within firms. The evidence also supports the notion that managers of multibusiness firms are constrained in the degree to which they can incentivize employees, given the firm-imposed reference group.The online appendix is available at https://doi.org/10.1287/orsc.2017.1109 .
Efficacy and safety of a new coverlet device on skin microclimate management: a pilot study in critical care patients
Authors: Forriez O. , Masseline J. , Coadic D. , David V. , Trouiller P. , Sztrymf B. 
Published: February 2017

Objective: To test the effect of a new coverlet device, allowing air circulation at the body/underlying surface interface, on skin microclimate management. Method: This prospective observational pilot study took place in a 15-bed university-affiliated intensive care unit. Overall, 34 mechanically ventilated patients were included. Skin humidity and temperature were monitored before and after the implementation of the tested device at the occiput, scapulas, buttocks and sacrum. Humidity and temperature were evaluated through surface skin impedance and an infra-red thermometer, respectively. Health professionals were asked to evaluate the device. Results: After implementation of the coverlet device, there was a rapid, sustained and significant decrease in skin humidity at all sites ranging from 6 % to 15 %, excluding the occiput. Skin temperature also significantly decreased from 1 % at both scapulas, but not at the other studied body sites. No side effects were observed. Health professionals reported that the device was easy and quick to install. Although they did not report a subjective improvement in skin moisture or temperature, they considered the device to be efficient. Conclusion: Although limited by its design, this pilot study suggests a good efficacy of the studied device on skin microclimate management. Further data are warranted to test the clinical implications of our findings.
Healing of an arterial leg ulcer by compression bandaging: a case report
Authors: Sanchez C. , Partsch H. 
Published: February 2017

This case report demonstrates that arterial ulcers may heal with compression therapy. The patient was a 72-year-old woman with elevated blood pressure and type II diabetes mellitus, who underwent angiography because of a painful, non-healing ulcer over the shin. The angiography showed multisegment arterial occlusive disease, not amenable to surgical revascularisation. After 4 months of wearing inelastic bandages, with increased pressure over the ulcer area and hypertension and diabetes under control, the patient was pain-free and the ulcer had healed. The ankle-brachial pressure index (ABPI) increased from 0.54 at the start of treatment to 0.70. In patients with arterial leg ulcers, properly applied compression therapy using increased pressure over the wound may lead to an improvement of the arterial flow and to complete healing.