bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNA methylation signatures and coagulation factors in the peripheral blood leucocytes of epithelial ovarian cancer
Authors: Li Lian , Zheng Hong , Huang Yubei , Huang Caiyun , Zhang Shuang , Tian Jing , Li Pei , Sood Anil K , Zhang Wei , Chen Kexin 
Published: June 2017

Abstract
Solid tumors are increasingly recognized as a systemic disease that is manifested by changes in DNA, RNA, proteins and metabolites in the blood. Whereas many studies have reported gene mutation events in the circulation, few studies have focused on epigenetic DNA methylation markers. To identify DNA methylation biomarkers in peripheral blood for ovarian cancer, we performed a two-stage epigenome-wide association study. In the discovery stage, we measured genome wide DNA methylation for 485 000 CpG sites in peripheral blood in 24 epithelial ovarian cancer (EOC) cases and 24 age-matched healthy controls. We selected 96 significantly differentially methylated CpG sites for validation using Illumina’s Custom VeraCode methylation assay in 206 EOC cases and 205 controls and 46 CpG sites validated in the independent replication samples. A set of 6 of these 46 CpG sites was found by the receiver operating characteristic analysis to have a prediction accuracy of 77.3% for all EOC (95% confidence interval: 72.9–81.8%). Pathway analysis of the genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (cg16962115, FDR = 1.24E−04), CADM1 (cg21933078, FDR = 1.22E−02) and NFATC1 (cg06784563, FDR = 1.46E−02). Furthermore, DNA methylation status in peripheral blood was correlated with platelet parameters/coagulation factor levels. This study discovered a panel of epigenetic liquid biopsy markers closely associated with overall immunologic conditions and platelet parameters/coagulation systems of the patients for detection of all stages and subtypes of EOC.
Full-waveform inversion of triplicated data using a normalized-correlation-coefficient-based misfit function
Authors: Tao Kai , Grand Stephen P. , Niu Fenglin 
Published: June 2017

Summary
In seismic full-waveform inversion (FWI), the choice of misfit function determines what information in data is used and ultimately affects the resolution of the inverted images of the Earth's structure. Misfit functions based on traveltime have been successfully applied in global and regional tomographic studies. However, wave propagation through the upper mantle results in multiple phases arriving at a given receiver in a narrow time interval resulting in complicated waveforms that evolve with distance. To extract waveform information as well as traveltime, we use a misfit function based on the normalized correlation coefficient (CC). This misfit function is able to capture the waveform complexities in both phase and relative amplitude within the measurement window. It is also insensitive to absolute amplitude differences between modeled and recorded data, which avoids problems due to uncertainties in source magnitude, radiation pattern, receiver site effects or even miscalibrated instruments. These features make the misfit function based on normalized CC a good candidate to achieve high-resolution images of complex geological structures when interfering phases coexist in the measurement window, such as triplication waveforms. From synthetic tests, we show the advantages of this misfit function over the cross-correlation traveltime misfit function. Preliminary inversion of data from an earthquake in Northeast China images a sharper and stronger amplitude slab stagnant in the middle of the transition zone than FWI of cross-correlation traveltime.
Automatable algorithms to identify nonmedical opioid use using electronic data: a systematic review
Authors: Canan Chelsea , Polinski Jennifer M , Alexander G Caleb , Kowal Mary K , Brennan Troyen A , Shrank William H 
Published: June 2017

AbstractObjectiveImproved methods to identify nonmedical opioid use can help direct health care resources to individuals who need them. Automated algorithms that use large databases of electronic health care claims or records for surveillance are a potential means to achieve this goal. In this systematic review, we reviewed the utility, attempts at validation, and application of such algorithms to detect nonmedical opioid use.Materials and MethodsWe searched PubMed and Embase for articles describing automatable algorithms that used electronic health care claims or records to identify patients or prescribers with likely nonmedical opioid use. We assessed algorithm development, validation, and performance characteristics and the settings where they were applied. Study variability precluded a meta-analysis.ResultsOf 15 included algorithms, 10 targeted patients, 2 targeted providers, 2 targeted both, and 1 identified medications with high abuse potential. Most patient-focused algorithms (67%) used prescription drug claims and/or medical claims, with diagnosis codes of substance abuse and/or dependence as the reference standard. Eleven algorithms were developed via regression modeling. Four used natural language processing, data mining, audit analysis, or factor analysis.DiscussionAutomated algorithms can facilitate population-level surveillance. However, there is no true gold standard for determining nonmedical opioid use. Users must recognize the implications of identifying false positives and, conversely, false negatives. Few algorithms have been applied in real-world settings.ConclusionAutomated algorithms may facilitate identification of patients and/or providers most likely to need more intensive screening and/or intervention for nonmedical opioid use. Additional implementation research in real-world settings would clarify their utility.
A technology-based patient and family engagement consult service for the pediatric hospital setting
Authors: Jackson Gretchen P , Robinson Jamie R , Ingram Ebone , Masterman Mary , Ivory Catherine , Holloway Diane , Anders Shilo , Cronin Robert M 
Published: June 2017

Abstract

Objective
The Vanderbilt Children’s Hospital launched an innovative Technology-Based Patient and Family Engagement Consult Service in 2014. This paper describes our initial experience with this service, characterizes health-related needs of families of hospitalized children, and details the technologies recommended to promote engagement and meet needs.

Materials and Methods
We retrospectively reviewed consult service documentation for patient characteristics, health-related needs, and consultation team recommendations. Needs were categorized using a consumer health needs taxonomy. Recommendations were classified by technology type.

Results
Twenty-two consultations were conducted with families of patients ranging in age from newborn to 15 years, most with new diagnoses or chronic illnesses. The consultation team identified 99 health-related needs (4.5 per consultation) and made 166 recommendations (7.5 per consultation, 1.7 per need). Need categories included 38 informational needs, 26 medical needs, 23 logistical needs, and 12 social needs. The most common recommendations were websites (50, 30%) and mobile applications (30, 18%). The most frequent recommendations by need category were websites for informational needs (39, 50%), mobile applications for medical needs (15, 40%), patient portals for logistical needs (12, 44%), and disease-specific support groups for social needs (19, 56%).

Discussion
Families of hospitalized pediatric patients have a variety of health-related needs, many of which could be addressed by technology recommendations from an engagement consult service.

Conclusion
This service is the first of its kind, offering a potentially generalizable and scalable approach to assessing health-related needs, meeting them with technologies, and promoting patient and family engagement in the inpatient setting.
A complete logic for Database Abstract State Machines1
Authors: Ferrarotti Flavio , Schewe Klaus-Dieter , Tec Loredana , Wang Qing 
Published: June 2017

AbstractIn database theory, the term database transformation was used to refer to a unifying treatment for computable queries and updates. Recently, it was shown that non-deterministic database transformations can be captured exactly by a variant of ASMs, the so-called Database Abstract State Machines (DB-ASMs). In this article we present a logic for DB-ASMs, extending the logic of Nanchen and Stärk for ASMs. In particular, we develop a rigorous proof system for the logic for DB-ASMs, which is proven to be sound and complete. The most difficult challenge to be handled by the extension is a proper formalization capturing non-determinism of database transformations and all its related features such as consistency, update sets or multisets associated with DB-ASM rules. As the database part of a state of database transformations is a finite structure and DB-ASMs are restricted by allowing quantifiers only over the database part of a state, we resolve this problem by taking update sets explicitly into the logic, i.e. by using an additional modal operator $[X]$, where $X$ is interpreted as an update set $\Delta$ generated by a DB-ASM rule. The DB-ASM logic provides a powerful verification tool to study properties of database transformations.
Grazing envelope evolution towards Type IIb supernovae
Authors: Soker Noam 
Published: June 2017

Abstract
I propose a scenario where the majority of the progenitors of Type IIb supernovae (SNe IIb) lose most of their hydrogen-rich envelope during a grazing envelope evolution (GEE). In the GEE, the orbital radius of the binary system is about equal to the radius of the giant star, and the more compact companion accretes mass through an accretion disc. The accretion disc is assumed to launch two opposite jets that efficiently remove gas from the envelope along the orbit of the companion. The efficient envelope removal by jets prevents the binary system from entering a common envelope evolution, at least for part of the time. The GEE might be continuous or intermittent. I crudely estimate the total GEE time period to be in the range of about hundreds of years, for a continuous GEE, and up to few tens of thousands of years for intermittent GEE. The key new point is that the removal of envelope gas by jets during the GEE prevents the system from entering a common envelope evolution, and by that substantially increases the volume of the stellar binary parameter space that leads to SNe IIb, both to lower secondary masses and to closer orbital separations.
Detection of helicoidal motion in the optical jet of PKS 0521−365
Authors: Jiménez-Andrade E. F. , Chavushyan V. , León-Tavares J. , Patiño-Álvarez V. M. , Olguín-Iglesias A. , Kotilainen J. , Falomo R. , Hyvönen T. 
Published: June 2017

Abstract
The jet activity of active galactic nuclei (AGNs), and its interaction with the interstellar medium, may play a pivotal role in the processes that regulate the growth and star formation of its host galaxy. Observational evidence that pinpoints the conditions of such interaction is paramount to unveil the physical processes involved. We report on the discovery of extended emission-line regions exhibiting an S-shaped morphology along the optical jet of the radio-loud AGN PKS 0521−365 (z = 0.055), by using long-slit spectroscopic observations obtained with FOcal Reducer/low dispersion Spectrograph 2 on the Very Large Telescope. The velocity pattern derived from the [O ii] λ3727 Å, H β λ4861 Å and [O iii] λλ4959, 5007 Å emission lines is well fitted by a sinusoidal function of the form: v(r) = αr1/2sin(βr1/2 + γ), suggesting helicoidal motions along the jet up to distances of 20 kpc. We estimate a lower limit for the mass of the outflowing ionized gas along the jet of ∼104 M⊙. Helical magnetic fields and jet precession have been proposed to explain helicoidal paths along the jet at pc scales; nevertheless, it is not clear yet whether these hypotheses may hold at kpc scales.
Neurosurgical Patients as Human Research Subjects: Ethical Considerations in Intracranial Electrophysiology Research
Authors: Chiong Winston , Leonard Matthew K , Chang Edward F 
Published: June 2017

Abstract
Intracranial electrical recordings and stimulation of neurosurgical patients have been central to the advancement of human neuroscience. The use of these methods has rapidly expanded over the last decade due to theoretical and technical advances, as well as the growing number of neurosurgical patients undergoing functional procedures for indications such as epilepsy, tumor resection, and movement disorders. These methods pose the potential for ethical conflict, as they involve basic neuroscientific research utilizing invasive procedures in human patients undergoing treatment for neurological illnesses. This review addresses technical aspects, clinical contexts, and issues of ethical concern, utilizing a framework that is informed by, but also departs from, existing bioethical literature on matters in clinical research. We conclude with proposals for improving informed consent processes to address potential problems specific to intracranial electrophysiology research, a general schema for scrutinizing research-related risk associated with different methods, and a call for the development of consensus to ensure continuing scientific progress alongside crucial patient protections in this promising area of human neuroscience.
The acidic tumor microenvironment: a target for smart cancer nano-theranostics
Authors: Feng Liangzhu , Dong Ziliang , Tao Danlei , Zhang Yicheng , Liu Zhuang 
Published: June 2017

Abstract
The acidic tumor microenvironment (TME), which mainly results from the high glycolytic rate of tumor cells, has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression. Recently, due to the increasing understanding of the acidic TME, it has been shown that the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms for the precise diagnosis and effective treatment of cancers. In this article, we will give a focused overview on the latest progress in utilizing this characteristic acidic TME as the target of nano-theranostics to enable cancer-specific imaging and therapy. The future perspectives in the development of acidic TME-targeting nanomedicine strategies will be discussed afterwards.
Investigating the Fear Avoidance Model in People With Whiplash
Authors: Pedler Ashley , Kamper Steven J. , Maujean Annick , Sterling Michele 
Published: June 2017

Objectives:
The aims of this study were to examine the relationship between fear of movement and activity levels in people with whiplash-associated disorders (WAD) over the first 3 months postinjury, to determine the mediating effect of: fear of movement on the relationship between catastrophizing and activity levels, and activity levels on the relationship between fear of movement and disability in patients with WAD.

Materials and Methods:
Ambulatory monitoring of physical activity was conducted for a minimum of 8 waking hours on 2 consecutive days within 4 weeks postinjury and at 12 weeks postinjury for 103 (74 female) people with WAD. Time spent in upright postures (uptime) and time in motion (TIM) were collected along with measures of pain, disability, pain catastrophizing, and fear of movement. The association of self-report outcome measures with uptime and TIM were examined. Mediation analyses were performed to determine the mediating effect of: fear of movement on the relationship between catastrophizing and activity, and activity levels on the relationship between fear of movement and disability.

Results:
Fear of movement was significantly related to uptime but not TIM. Mediation analyses showed that the relationship between fear of movement and disability was not mediated by activity levels, and that the relationship between catastrophizing and activity levels was not mediated by fear of movement.

Discussion:
Our data suggests measures of Fear Avoidance Model are not related to general physical activity in people with WAD. Investigation of movements specific to the cervical spine and alternative explanatory models may be required.
Pain-related Activity Management Patterns and Function in Patients With Fibromyalgia Syndrome
Authors: Racine Mélanie , Galán Santiago , de la Vega Rocío , Tomé Pires Catarina , Solé Ester , Nielson Warren R. , Miró Jordi , Moulin Dwight E. , Jensen Mark P. 
Published: June 2017

Objectives:
To clarify the importance of avoidance, pacing, and overdoing pain-related activity management patterns as predictors of adjustment in patients with fibromyalgia syndrome.

Methods:
A total of 119 tertiary care patients with fibromyalgia syndrome who agreed to be part of an activity management pain program completed a survey, which requested information about demographics, pain intensity and pain interference, psychological and physical function, and pain-related activity management patterns. Hierarchical regression analyses were used to identify the unique contributions of the 3 different pain-related activity management patterns (avoidance, pacing, and overdoing) to the prediction of pain interference, psychological function, and physical function.

Results:
The avoidance pattern was a significant and unique predictor of worse psychological and physical function as well as greater pain interference. Pacing was significantly associated with less pain interference and better psychological function, whereas overdoing was not found to predict patient functioning.

Discussion:
The findings confirm the importance of pain-related activity management patterns as predictors of patient function, and support the necessity of addressing these factors in chronic pain treatment. In addition, the results suggest that targeting increases in activity pacing and decreases in pain avoidance, specifically, might yield the best patient outcomes. However, further research to evaluate this possibility is necessary.
Incremental Hospital Cost and Length-of-stay Associated With Treating Adverse Events Among Medicare Beneficiaries Undergoing Cervical Spinal Fusion During Fiscal Year 2013 and 2014
Authors: Culler Steven D. , McGuire Kevin J. , Little Kenneth M. , Jevsevar David , Shea Kevin , Schlosser Michael , Ambrose Karen E. , Simon April W. 
Published: June 2017

Study Design.
A retrospective study.

Objective.
To report the incremental hospital resources consumed with treating adverse events experienced by Medicare beneficiaries undergoing a two or three vertebrae level cervical spinal fusion.

Summary of Background Data.
Hospitals are increasingly at financial risk for patients experiencing adverse events due “pay for performance.” Little is known about incremental resources consumed when treating patients who experienced an adverse event after cervical spinal fusions.

Methods.
Fiscal years 2013 and 2014 Medicare Provider Analysis and Review file was used to identify 86,265 beneficiaries who underwent 2 or 3 vertebrae level cervical spinal fusion. International Classification of Diseases 9th Clinical Modification diagnostic and procedure codes were used to identify 10 adverse events. This study estimated both the observed and risk-adjusted incremental hospital resources consumed (cost [2014 US $] and length-of-stay) in treating beneficiaries experiencing each adverse event.

Results.
Overall, 6.2% of beneficiaries undergoing cervical spinal fusion experienced at least one of the study's adverse events. Beneficiaries experiencing any complication consumed significantly more hospital resources (incremental cost of $28,638) and had longer length-of-stay (incremental stays of 9.1 days). After adjusting for patient demographics and comorbid conditions, incremental cost of treating adverse events ranged from $42,358 (infection) to $10,100 (dural tear).

Conclusion.
Adverse events frequently occur and add substantially to the hospital costs of patients undergoing cervical spinal fusion. Shared decision-making instruments should clearly provide these risk estimates to the patient before surgical consideration. Investment in activities that have been shown to reduce specific adverse events is warranted, and this study may allow health systems to prioritize performance improvement areas.

Level of Evidence: 3
Prevention of βeta-adrenergic–induced Adverse Cardiac Remodeling by Gonadectomy in Male but Not Female Spontaneously Hypertensive Rats
Authors: Magubane Mhlengi , Michel Frederic S. , Erlwanger Kennedy H. , Norton Gavin R. , Woodiwiss Angela J. 
Published: June 2017

Abstract:
Chronic β-adrenergic stimulation induces left ventricular (LV) remodeling in male but not in female spontaneously hypertensive rats (SHRs). However, the role of sex steroids in mediating these effects has not been determined. The aim of the present study was to assess the impact of gonadectomy on isoproterenol (ISO)-induced LV remodeling in SHR. Gonadectomy was performed on 9-month-old male and female SHR. LV remodeling was induced by daily ISO injection (0.04 mg/kg) for 6 months. LV dimensions and functions were determined in vivo by echocardiography and ex vivo using isolated perfused heart preparations. In males, ISO increased LV end diastolic (LVED) diameter in sham-operated (in millimeter, ISO: 8.12 ± 0.26 vs. Con: 6.67 ± 0.20, P = 0.0002) but not in castrated SHR (ISO: 6.97 ± 0.31 vs. Con: 6.53 ± 0.15, P = 0.66). Similarly, ISO increased the volume intercept of the LVED pressure–volume relationship in sham-operated (in milliliters, ISO: 0.26 ± 0.02 vs. Con: 0.19 ± 0.01, P = 0.01) but not in castrated SHR (ISO: 0.17 ± 0.02 vs. Con: 0.17 ± 0.01, P = 0.99). In females, ISO only increased LVED diameter (ISO: 6.43 ± 0.13 vs. Con: 6.07 ± 0.09, P = 0.027). However, ovariectomy did not modify any LV dimensions measured in vivo and ex vivo. In conclusion, testosterone may be responsible for the chronic β-adrenergic–induced LV dilation and eccentric remodeling observed in male but not female SHR.
Associations between high-risk alcohol consumption and sarcopenia among postmenopausal women
Authors: Kwon Yu-Jin , Lim Hyoung-Ji , Lee Yong-Jae , Lee Hye-Sun , Linton John A. , Lee Jae Woo , Kang Hee-Taik 
Published: June 2017

Abstract

Objective:
Sarcopenia is an age-related process, leading to cardio-metabolic diseases and disabilities. High-risk drinking is also closely related to diabetes, hypertension, and dyslipidemia, which are modifiable risk factors for sarcopenia. In the present study, we aimed to investigate the association between alcohol-drinking patterns and sarcopenia in Korean postmenopausal women.

Methods:
Data from 2,373 postmenopausal women were analyzed from the 2008 to 2011 Korean National Health and Nutrition Examination Survey. We defined sarcopenia as two standard deviations below the sex-specific means of the appendicular skeletal muscle/weight (percentage) values of a young reference group. Participants were categorized into three groups according to alcohol-drinking patterns, as assessed by the Alcohol Use Disorders Identification Test questionnaire. The odds ratios and 95% confidence intervals for sarcopenia were calculated using multiple logistic regression analyses.

Results:
In total, 8.2% of Korean postmenopausal women met criteria for sarcopenia. The prevalence of sarcopenia increased from low-risk to high-risk alcohol-drinking groups as follows: 7.6, 11.0, and 22.7%, respectively. Compared with the low-risk group, the odds ratio (95% confidence interval) for the high-risk group was 4.29 (1.87-9.82) after adjusting for age, body mass index, systolic blood pressure, total cholesterol, fasting blood glucose, household income, education level, daily calorie intake, current smoking and regular exercise, and household food security status

Conclusions:
High-risk alcohol drinking was associated with a higher risk of sarcopenia in postmenopausal Korean women.