bluuebunny/crossref_metadata_2025_split huggingface dataset:
Labyrinthectomy and Vestibular Neurectomy for Intractable Vertiginous Symptoms
Authors: Alarcón Alfredo , Hidalgo Lourdes , Arévalo Rodrigo , Diaz Marite 
Published: March 2017

Introduction Labyrinthectomy and vestibular neurectomy are considered the surgical procedures with the highest possibility of controlling medically untreatable incapacitating vertigo. Ironically, after 100 years of the introduction of both transmastoid labyrinthectomy and vestibular neurectomy, the choice of which procedure to use rests primarily on the evaluation of the hearing and of the surgical morbidity.
Objective To review surgical labyrinthectomy and vestibular neurectomy for the treatment of incapacitating vestibular disorders.
Data Sources PubMed, MD consult and Ovid-SP databases.
Data Synthesis In this review we describe and compare surgical labyrinthectomy and vestibular neurectomy. A contrast between surgical and chemical labyrinthectomy is also examined. Proper candidate selection, success in vertigo control and complication rates are discussed on the basis of a literature review.
Conclusions Vestibular nerve section and labyrinthectomy achieve high and comparable rates of vertigo control. Even though vestibular neurectomy is considered a hearing sparing surgery, since it is an intradural procedure, it carries a greater risk of complications than transmastoid labyrinthectomy. Furthermore, since many patients whose hearing is preserved with vestibular nerve section may ultimately lose that hearing, the long-term value of hearing preservation is not well established. Although the combination of both procedures, in the form of a translabyrinthine vestibular nerve section, is the most certain way to ablate vestibular function for patients with no useful hearing and disabling vertigo, some advocate for transmastoid labyrinthectomy alone, considering that avoiding opening the subarachnoid space minimizes the possible intracranial complications. Chemical labyrinthectomy may be considered a safer alternative, but the risks of hearing loss when hearing preservation is desired are also high.
Telemedicine for gastrointestinal endoscopy: The Endoscopic Club E-conference in the Asia Pacific Region
Authors: Ho Shiaw-Hooi , Rerknimitr Rungsun , Kudo Kuriko , Tomimatsu Shunta , Ahmad Mohamad , Aso Akira , Seo Dong , Goh Khean-Lee , Shimizu Shuji 
Published: March 2017

Abstract
Background and study aims An Endoscopic Club E-conference (ECE) was set up in May 2014 to cater to increased demand for gastrointestinal endoscopy-related teleconferences in the Asia-Pacific region which were traditionally organized by the medical working group (MWG) of Asia-Pacific Advanced Network. This study describes how the ECE meeting was run, examines the group dynamics, outlines feedback and analyzes factors affecting the enthusiasm of participants. It is hoped that the findings here can serve as guidance for future development of other teleconference groups.
Methods The preparation, running of and feedback on the ECE teleconference were evaluated and described. The country’s economic situation, time zone differences, connectivity with a research and education network (REN) and engineering cooperation of each member were recorded and analyzed with regard to their association with participant enthusiasm, which was taken as participation in at least 50 % of the meetings since joining. Associations were calculated using 2-way table with chi-square test to generate odds ratio and P value.
Results To date, ECE members have increased from 7 to 29 (increment of 314 %). Feedback received indicated a high level of satisfaction with program content, audiovisual transmission and ease of technical preparation. Upper gastrointestinal luminal endoscopy-related topics were the most favored program content. Those topics were presented mainly via case studies with a focus on management challenges. Time zone differences of more than 6 hours and poor engineering cooperation were independently associated with inactive participation (P values of 0.04 and 0.001 respectively).
Conclusions Good program content and high-quality audiovisual transmission are keys to the success of an endoscopic medical teleconference. In our analysis, poor engineering cooperation and discordant time zones contributed to inactive participation while connectivity with REN and a country’s economic situation were not significantly associated with participant enthusiasm.
Integrating Commercial Fisheries Registration, Education, and Social Science in the U.S. Virgin Islands
Authors: Crosson Scott , Hibbert Lia 
Published: March 2017

Abstract
The collection of economic data on commercial fisheries without a formal dealer network often requires time and labor-intensive field research. Previous fisheries social and economic research in the Caribbean has embraced stratified or cluster sampling techniques as an efficient alternative to seeking large random samples. We explore an alternative approach wherein fisheries education and research are incorporated into a registration process structured around small group interactions in the U.S. Virgin Islands (USVI). We find that this approach can raise response rates and save considerable effort, but the surveys themselves must be very brief.
Received February 11, 2016; accepted October 28, 2016 Published online March 1, 2017
Reconsidering the technologies of intellectual inquiry in curriculum design
Authors: Costa Cristina , Harris Lisa 
Published: March 2017

ABSTRACTThis paper reports on the design and delivery of classroom pedagogies and students’ engagement with it in two different UK universities. Under the banner of curriculum design and Bourdieu's curriculum principles, the study set out to create modules that provided students with an interdisciplinary perspective on how the web is changing the way citizens live, interact and learn. Focusing on the idea that the web is becoming a tool of intellectual inquiry and an instrument of reproduction of knowledge inequality, the goal of this research was to transform knowledge practices by encouraging a learning habitus that relies on knowing how to learn rather than becoming ‘knowledgeable.’The paper concludes that the Bourdieuian perspective on curriculum design still holds currency in the digital age, given that it shares an epistemology of practice similar to that advocated by a digital participatory culture. We also offer a critique to our approach, using Bourdieu's logic of practice to examine how education as a field displays (hidden) rules that students embody as their learning habitus. As students’ learning practices become doxified through their educational trajectories, learners find it difficult to engage with a curriculum that aims to diversify pedagogical structures and reflect a changing society.
From divergent evolution to witting cross‐fertilisation: the need for more awareness of potential inter‐discursive communication regarding students' extended historical writing
Authors: Carroll James Edward 
Published: March 2017

ABSTRACTHistory education stakeholders in England have consistently judged that some students find formal historical writing prohibitively difficult due to the demands of constructing an extended argument. While policy makers have agreed students need support in their historical writing, recurring themes in centralised resourcing have been wastage, incoordination and replication. Furthermore, two concurrent but largely disconnected discourses have developed and promulgated initiatives relevant to students’ extended historical writing: ‘genre theorists’ and the ‘history teachers’ extended writing movement’. Despite certain goals held in common participants in the two discourses have tended to talk past one another with concomitant issues in resourcing. Unsystematic, cross‐fertilisation between the discourses has led to cycles of genre theory being collectively discovered, forgotten, and rediscovered by history teachers with knowledge not being built cumulatively. Furthermore both discourses have independently developed similar initiatives in a form of convergent evolution resulting in duplication of labour. Finally, divergent evolution has occurred where genre theorists have advocated approaches that are increasingly redundant for history teachers’ requirements. A more activist stance is therefore required to ensure meaningful inter‐discursive communication between genre theorists and the history teachers’ ‘extended writing movement’ to ensure efficacy in developing approaches to improving students’ extended historical writing.
A penalized regression approach to haplotype reconstruction of viral populations arising in early HIV/SIV infection
Authors: Leviyang Sivan , Griva Igor , Ita Sergio , Johnson Welkin E 
Published: March 2017

Abstract

Motivation
Next generation sequencing (NGS) has been increasingly applied to characterize viral evolution during HIV and SIV infections. In particular, NGS datasets sampled during the initial months of infection are characterized by relatively low levels of diversity as well as convergent evolution at multiple loci dispersed across the viral genome. Consequently, fully characterizing viral evolution from NGS datasets requires haplotype reconstruction across large regions of the viral genome. Existing haplotype reconstruction algorithms have not been developed with the particular characteristics of early HIV/SIV infection in mind, raising the possibility that better performance could be achieved through a specifically designed algorithm.

Results
Here, we introduce a haplotype reconstruction algorithm, RegressHaplo, specifically designed for low diversity and convergent evolution regimes. The algorithm uses a penalized regression that balances a data fitting term with a penalty term that encourages solutions with few haplotypes. The regression covariates are a large set of potential haplotypes and fitting the regression is made computationally feasible by the low diversity setting. Using simulated and in vivo datasets, we compare RegressHaplo to PredictHaplo and QuRe, two existing haplotype reconstruction algorithms. RegressHaplo performs better than these algorithms on simulated datasets with relatively low diversity levels. We suggest RegressHaplo as a novel tool for the investigation of early infection HIV/SIV datasets and, more generally, low diversity viral NGS datasets.

Availability and Implementation
https://github.com/SLeviyang/RegressHaplo
No-take marine reserves are the most effective protected areas in the ocean
Authors: Sala Enric , Giakoumi Sylvaine 
Published: March 2017

Abstract
Marine protected areas (MPAs) are an essential tool for reversing the global degradation of ocean life. Hence, it is important to know which types of MPAs are more effective, and under which conditions. No-take marine reserves – the MPAs with stronger protection – are very effective in restoring and preserving biodiversity, and in enhancing ecosystem resilience. A new meta-analysis of previous studies shows that biomass of whole fish assemblages in marine reserves is, on average, 670% greater than in adjacent unprotected areas, and 343% greater than in partially-protected MPAs. Marine reserves also help restore the complexity of ecosystems through a chain of ecological effects (trophic cascades) once the abundance of large animals recovers sufficiently. Marine reserves may not be immune to the effects of climate change, but to date, reserves with complex ecosystems are more resilient than unprotected areas. Although marine reserves were conceived to protect ecosystems within their boundaries, they have also been shown to enhance local fisheries and create jobs and new incomes through ecotourism.
Constructing the informatics and information technology foundations of a medical device evaluation system: a report from the FDA unique device identifier demonstration
Authors: Drozda Joseph P , Roach James , Forsyth Thomas , Helmering Paul , Dummitt Benjamin , Tcheng James E 
Published: March 2017

Abstract

Objective
The US Food and Drug Administration (FDA) has recognized the need to improve the tracking of medical device safety and performance, with implementation of Unique Device Identifiers (UDIs) in electronic health information as a key strategy. The FDA funded a demonstration by Mercy Health wherein prototype UDIs were incorporated into its electronic information systems. This report describes the demonstration’s informatics architecture.

Methods
Prototype UDIs for coronary stents were created and implemented across a series of information systems, resulting in UDI-associated data flow from manufacture through point of use to long-term follow-up, with barcode scanning linking clinical data with UDI-associated device attributes. A reference database containing device attributes and the UDI Research and Surveillance Database (UDIR) containing the linked clinical and device information were created, enabling longitudinal assessment of device performance. The demonstration included many stakeholders: multiple Mercy departments, manufacturers, health system partners, the FDA, professional societies, the National Cardiovascular Data Registry, and information system vendors.

Results
The resulting system of systems is described in detail, including entities, functions, linkage between the UDIR and proprietary systems using UDIs as the index key, data flow, roles and responsibilities of actors, and the UDIR data model.

Conclusion
The demonstration provided proof of concept that UDIs can be incorporated into provider and enterprise electronic information systems and used as the index key to combine device and clinical data in a database useful for device evaluation. Keys to success and challenges to achieving this goal were identified. Fundamental informatics principles were central to accomplishing the system of systems model.
Physical processes in the vessel
Authors: Gasser T. Christian 
Published: March 2017

Abstract
Evolution has developed a complex cardiovascular system, the analysis of which involves many physical disciplines. Specifically, cardiovascular function critically depends on the proper interaction between blood and the vessel wall, such that haemodynamics-based biomechanical factors are a common denominator of cardiovascular pathologies. This chapter reviews biomechanics-related physical processes in the vessel. Specifically, mechanical load transition mechanisms in blood and the vessel wall, blood-wall interaction phenomena, as well as simple analytical solutions to Newton’s second law of mechanics are discussed. Albeit that such simple analytical relations are very useful when exploring physical processes in the vasculature, their application is limited and cardiovascular analysis often requires more advanced computational methods so as to draw conclusions from Newton’s law. Most important, the proper application of either simple or more advanced physical models requires close interaction between engineering and medical disciplines.
Behavioral interventions to improve asthma outcomes: a systematic review of recent publications
Authors: Mosnaim Giselle S. , Akkoyun Esra , Eng Joshua , Shalowitz Madeleine U. 
Published: March 2017

Purpose of review
Asthma outcomes are influenced by factors at multiple ecological levels: the individual and his/her family, home, medical care, and community. This systematic review describes recently published single-level and multilevel behavioral interventions to improve asthma outcomes.

Recent findings
Of the 23 total title/abstracts reviewed in the original systematic search of PubMed, Ovid, Scopus, PsychINFO, and CIHAHL reference review databases, six met inclusion criteria. Five of the studies focused on low-income and/or minority populations. Promising interventions include culturally tailored online asthma self-management programs and family-centered asthma education delivered at the bedside during hospitalization for an acute asthma exacerbation.

Summary
Culturally, tailored online self-management programs offer difficult-to-reach populations asthma support that can be completed at the time and pace most convenient for the individual user. Family-focused asthma education, delivered at the bedside during an acute asthma hospitalization by highly motivated lay volunteers, is an efficacious and low-cost approach to improving pediatric asthma self-management.
Novel immunotherapy and treatment modality for severe food allergies
Authors: Nagakura Ken-ichi , Sato Sakura , Yanagida Noriyuki , Ebisawa Motohiro 
Published: March 2017

Purpose of review
In recent years, many studies on oral immunotherapy (OIT) have been conducted; however, few have focused on severe food allergies. The purpose of this review was to assess the efficacy and safety of oral immunotherapies for patients with severe food allergy.

Recent findings
We reviewed multiple immunotherapy reports published within a few years or reports focusing on severe food allergies. We also investigated recent studies on OIT and novel food allergy management.

Summary
Immunotherapies targeting low-dose antigen exposure and oral food challenges using low-dose target volumes may be safer than conventional OIT. It is necessary to consider which immunotherapy regimen is appropriate based on allergy severity of the patient.
Effect of Thoracic Epidural Anesthesia on Ventricular Excitability in a Porcine Model
Authors: Howard-Quijano Kimberly , Takamiya Tatsuo , Dale Erica A. , Yamakawa Kentaro , Zhou Wei , Buckley Una , Mahajan Aman 
Published: March 2017

Abstract

Background
Imbalances in the autonomic nervous system, namely, excessive sympathoexcitation, contribute to ventricular tachyarrhythmias. While thoracic epidural anesthesia clinically suppresses ventricular tachyarrhythmias, its effects on global and regional ventricular electrophysiology and electrical wave stability have not been fully characterized. The authors hypothesized that thoracic epidural anesthesia attenuates myocardial excitability and the proarrhythmic effects of sympathetic hyperactivity.

Methods
Yorkshire pigs (n = 15) had an epidural catheter inserted (T1 to T4) and a 56-electrode sock placed on the heart. Myocardial excitability was measured by activation recovery interval, dispersion of repolarization, and action potential duration restitution at baseline and during programed ventricular extrastimulation or left stellate ganglion stimulation, before and 30 min after thoracic epidural anesthesia (0.25% bupivacaine).

Results
After thoracic epidural anesthesia infusion, there was no change in baseline activation recovery interval or dispersion of repolarization. During programmed ventricular extrastimulation, thoracic epidural anesthesia decreased the maximum slope of ventricular electrical restitution (0.70 ± 0.24 vs. 0.89 ± 0.24; P = 0.021) reflecting improved electrical wave stability. Thoracic epidural anesthesia also reduced myocardial excitability during left stellate ganglion stimulation–induced sympathoexcitation through attenuated shortening of activation recovery interval (−7 ± 4% vs. −4 ± 3%; P = 0.001), suppression of the increase in dispersion of repolarization (313 ± 293% vs. 185 ± 234%; P = 0.029), and reduction in sympathovagal imbalance as measured by heart rate variability.

Conclusions
Our study describes the electrophysiologic mechanisms underlying antiarrhythmic effects of thoracic epidural anesthesia during sympathetic hyperactivity. Thoracic epidural anesthesia attenuates ventricular myocardial excitability and induces electrical wave stability through its effects on activation recovery interval, dispersion of repolarization, and the action potential duration restitution slope.
The Effectiveness of Matrix Cauterization With Bichloracetic Acid in the Treatment of Ingrown Toenails
Authors: Terzi Erdinc , Guvenc Ulas , Tursen Belma , Tursen Umit , Kaya Tamer Irfan 
Published: March 2017

BACKGROUND
Chemical matricectomy is performed mainly by 2 agents, phenol and sodium hydroxide. Chemical matricectomy with phenol has a low recurrence rate and good cosmetic results, but it produces extensive tissue destruction and can result in drainage and a delayed healing time. These adverse effects have brought forward the use of chemical agents such as sodium hydroxide and trichloroacetic acid for matricectomy.

OBJECTIVE
This prospective study aimed mainly to evaluate the efficacy of partial nail avulsion and selective chemical cauterization of the matrix using 90% bichloracetic acid (BCA) in the treatment of the ingrown nails.

MATERIALS AND METHODS
A total of 30 patients with 58 ingrown toenail edges were included in this study. All of the patients underwent chemical matricectomy with 90% BCA after partial nail avulsion. Adverse effects such as postoperative pain and drainage were minimal in most of the patients.

RESULTS
One patient who underwent matricectomy had recurrence in a single nail edge (1.8%) at the 12th month of the follow-up. No recurrence was observed in 29 patients during mean follow-up period. This was considered to be statistically significant (p < .001).

CONCLUSION
This is the first study to use BCA for the treatment of ingrown toenail. Partial nail avulsion followed by BCA matricectomy is a safe, simple, and effective method with low rates of postoperative morbidity and high rates of success. Therefore, partial nail avulsion and BCA matricectomy can be used as an alternative treatment method for the treatment of ingrown toenails.
Improving Pressure Ulcer Reconstruction: Our Protocol and the COP (Cone of Pressure) Flap
Authors: Gargano Francesco , Edstrom Lee , Szymanski Karen , Schmidt Scott , Bevivino Jack , Zienowicz Richard , Stark Jennifer , Taylor Helena O. , Podda Silvio , Liu Paul 
Published: March 2017

Background:
Surgical treatment of pressure ulcers is challenging for high recurrence rates. Deepithelialized flaps have been used previously with the aim to eliminate shearing forces and the cone of pressure (COP) effect. The goal of this study is to adopt a standardized protocol and evaluate if 2 different flap techniques affect outcomes.

Methods:
The novel COP flap is illustrated. Twenty patients were prospectively treated with flap coverage over a 36-month period. According to the flap type, patients were assigned to 2 groups: group 1 with 11 patients treated with the COP flap and group 2 with 9 patients treated with conventional flap without anchoring technique. We adopted a standardized protocol of debridement, tissue cultures, and negative-pressure wound therapy. Rotation fasciocutaneous flaps were used for both groups and mean follow-up was 19 months. The COP flap is a large deepithelialized rotation flap inset with transcutaneous nonabsorbable bolster sutures. The 2 groups were comparable for demographics and ulcer location and size (P < 0.05). Five patients showed positive cultures and were treated with antibiotics and negative-pressure therapy before surgery.

Results:
Recurrence rates were 12% in the COP flap group and 60% in the conventional flap coverage group (P < 0.001). Results were compared at 16-month follow-up.

Conclusions:
The COP flap significantly reduces recurrences and eliminates shearing forces, suture ripping, and tension on superficial soft-tissue layers. The technique can be applied to both ischial and sacral pressure sores. The flap provides padding over bony prominence without jeopardizing flap vascularity.