bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Performance and Efficiency of Hardware and Software Firewalls
Authors: Konikiewicz Wojciech , Markowski Marcin 
Published: February 2018

Abstract
Firewalls are key elements of network security infrastructure. They should guarantee the proper level of security and, at the same time, the satisfying performance in order to not increase the packet delay in the network. In the paper, we present the comparative study on performance and security of a few firewall technologies including hardware, software and virtual solutions. Three important criteria are considered: the maximal throughput of firewall, the introduced delay and the ability to resist Denial of Service attacks. We report results of experiments, present analysis and formulate a few practical conclusions.
Metabolic features and changes in glucose-induced serum glucagon-like peptide-1 levels in children with hypothalamic obesity
Authors: Chai-udom Rapeepun , Aroonparkmongkol Suphab , Sahakitrungruang Taninee 
Published: February 2018

Abstract

Background
Hypothalamic damage may alter glucagon-like peptide-1 (GLP-1) secretion and be involved in the pathogenesis of obesity. We aim to evaluate the metabolic features and the dynamic changes of GLP-1 levels during an oral glucose tolerance test (OGTT) in children with hypothalamic obesity (HO) compared with simple obesity controls.

Methods
Subjects included eight patients (six females, aged 9–16 years) with hypothalamo-pituitary tumors who later developed obesity and eight controls with simple obesity matched for age, body mass index (BMI), gender and puberty. We assessed the metabolic syndrome features, fat mass, severity of hyperphagia using a standardized questionnaire, and measured glucose, insulin and GLP-1 levels during a standard 75 g OGTT.

Results
Age, gender distribution, pubertal status and BMI-Z scores were not significantly different. Subjects with HO had higher fasting triglycerides (TG) than controls (128 vs. 94 mg/dL; p=0.05). Four HO subjects and three controls met the criteria for the metabolic syndrome. Fasting and 120 min post-glucose load GLP-1 levels were significantly higher in HO patients than in controls (21.9 vs. 19.7 pg/mL; p=0.025, 22.1 vs. 17.7 pg/mL; p=0.012). Patients with HO had significantly higher hyperphagia scores than in simple obese controls (13 vs. 2.5; p=0.012).

Conclusions
Patients with HO appear to have more metabolic complications and hyperphagia than controls with simple obesity. Impaired satiety may play an important role in HO. Fasting and glucose-induced serum GLP-1 concentrations seem to be altered in HO patients and could be a part of the pathogenesis of HO.
Basic and low-risk substances under European Union pesticide regulations: a new choice for biorational portfolios of small and medium-sized enterprises
Authors: Marchand Patrice A. 
Published: February 2018

Abstract
Directive 2009/128/EC of the European Parliament and of the Council of 21 October 2009 established a framework for Community action to bring about the sustainable use of pesticides and encourage low concern biorationals. Basic substances described in article 23 of EC phytopharmaceutical Regulation No 1107/2009 consist of a new operative category for crop protection products with 16 substances approved so far. Another status, ruled by article 22 is also operative with 11 approved low-risk substances (see EU pesticide database). Now small and medium-sized enterprises (SMEs) have the opportunity to register biorationals at the EU level in one of the two categories. Our institute previously provided technical expertise on how to complete the Basic Substance Application (BSA), together with a description of first results. However it is clear that there is a need for a shorter survey of the two parallel procedures for SMEs. Here we provide a concise sequence of the necessary steps for SMEs, including strategic approach, a rapid steps description, a timeframe for the global pathway, up to the final step, after approval by the Plants, Animals, Food and Feed Standing Committee (PAFF). We present in detail the advantages and limitations of the two statutes. The introduction of approved substances into organic farming is also discussed. Currently basic and low-risk substance pathways are now accessible for biorationals handled by SMEs. Therefore, the option is open for SMEs to seek a possibly low-risk active substances endorsement with market authorizations or a basic substance approval with no plant protection product claims depending on the selected strategy.
Crystal structure and optical properties of diaqua-tris(nitrato-κ2
O,O′)-bis(4,4,5,5-tetramethyl-2-(p-pyridyl)imidazoline-1-oxyl 3-oxide-κN)praseodymium(III), C24H36N9O15Pr
Authors: Li Dongjiao , Zhao Zhiyuan , Yao Xiuxiu , Chen Zhen , Wu Xiaoqiang , Zheng Xiuwen 
Published: February 2018

Abstract
C24H36N9O15Pr, monoclinic C2/c (no. 15), a = 23.686(9) Å, b = 11.727(5) Å, c = 12.001(5) Å, β = 94.852(4) V = 3322(2) Å3, Z = 4, R
gt(F) = 0.0282, wR
ref(F
2) = 0.0769, T = 293 K.
Borenium and boronium ions of 5,6-dihydro-dibenzo[c,e][1,2]azaborinine and the reaction with non-nucleophilic base: trapping of a dimer and a trimer of BN-phenanthryne by 4,4′-di-tert-butyl-2,2′-bipyridine
Authors: Hahn Jennifer , Biswas Sunanda , Maichle-Mössmer Cäcilia , Schrenk Claudio , Schnepf Andreas , Bettinger Holger F. 
Published: February 2018

Abstract
6-Chloro-5,6-dihydro-dibenzo[c,e][1,2]azaborinine (1) reacts with pyridine derivatives to borenium or boronium ions. The boronium ion obtained from reaction with an excess of pyridine could be characterized structurally and transforms into the borenium ion in solution. The reaction of 1 with 2,2′-bipyridine (a) and derivatives (b: 6,6′-dimethyl; c: 4,4′-di-tert-butyl) results in spirocyclic boronium ions 8a–c of which 8b could be characterized by X-ray crystallography. Despite the chelate effect, the spirocyclic boronium ions readily undergo hydrolysis or alcoholysis. Treatment of the spirocyclic boronium ion 8c with potassium hexamethyl disilazide (KHMDS) results in neutral products that are monomers, dimers, or trimers of dibenzo[c,e][1,2]azaborinine (“BN-phenanthryne”) trapped with 4,4′-di-tert-butyl-2,2′-bipyridine by formation of B–C, B–N, or dative B–N bonds, indicative of deprotonation of NH and CH bonds of the boronium ion by KHMDS.
Preparation of hydroxyapatite-titanium particle hierarchical filled polyetheretherketone functional gradient biocomposites
Authors: Pan Yusong , Ding Jie 
Published: February 2018

Abstract
Functional gradient biomaterials have been widely applied in the biomedical field due to their designable structure and performance. In this paper, hydroxyapatite-titanium particles hierarchical filled polyetheretherketone functional gradient biocomposites [(HA-Ti)/PEEK FGBm] were successfully fabricated through combination of a layer-by-layer casting method and hot pressing technology. The microstructure and morphology of the FGBm were investigated by X-ray diffraction (XRD), Fourier transform infrared (FTIR), energy dispersive X-ray analysis spectrometry (EDS) and scanning electron microscopy (SEM). The results of XRD and EDS verified that the components of the FGBm consist of HA, Ti and PEEK. FTIR and SEM studies showed that the existence of TiO2 thin film on the surface of Ti particles was beneficial to improve the wettability of Ti particles to the PEEK matrix, thus increasing the interfacial bonding strength between Ti particles and PEEK matrix. The SEM observation revealed that the size of HA particles in (HA-Ti)/PEEK FGBm was on the nano-scale and that of Ti particles was on the micron-scale. Furthermore, several typical microstructures such as micro-pores, dimple-like, and encapsulated-like morphologies in (HA-Ti)/PEEK FGBm were observed by SEM. With the rise of Ti and HA particle content in PEEK matrix, the distribution of them in PEEK matrix becomes more and more inhomogeneous and they tend to agglomerate.
99mTc-HYNIC-(Ser)3-LTVPWY peptide bearing tricine as co-ligand for targeting and imaging of HER2 overexpression tumor
Authors: Aligholikhamseh Nazan , Ahmadpour Sajjad , Khodadust Fatemeh , Abedi Seyed Mohammad , Hosseinimehr Seyed Jalal 
Published: February 2018

Abstract
Human epidermal growth factor receptor 2 (HER2) is overexpressed in several cancers. Today’s tumor targeting is receiving more attention due to its specificity to target receptor-dependent cancers. The aim of this study was to evaluate the 99mTc-HYNIC-(tricine)-(Ser)3-LTVPWY peptide for tumor targeting and imaging with overexpression of HER2. HYNIC-(Ser)3-LTVPWY peptide was labeled with 99mTc using tricine as a co-ligand at room temperature. Specific binding of this radiolabeled peptide was assessed on four cancer cell lines with different levels of HER2 receptor expression. Also the affinity of 99mTc-HYNIC-(tricine)-(Ser)3-LTVPWY peptide to the HER2 receptor was evaluated in the SKOV-3 cell line. Biodistribution study of this radiolabeled peptide was performed in SKOV-3 tumor bearing nude mice. The HYNIC conjugated peptide was simply labeled with 99mTc radionuclide with high labeling efficiency about 98±1% showing favorable stability in normal saline and human serum. In the presence of unlabeled peptide as competitor, the HER2 binding capacity of the radiolabeled peptide reduced (approximately five-fold). The KD and Bmax values were found 2.6±0.5 nM and (2.6±0.1)×106, respectively. The tumor/muscle ratios for this radiotracer were determined 1.17±0.77, 1.15±0.32 and 2.65±0.32 at 1, 2 and 4 h after injection, respectively. Presaturation of HER2 receptors in SKOV-3 xenografted nude mice showed a reduction in the tumor/muscle ratio confirming in vivo specificity of the peptide. According to SPECT imaging, the tumor was visualized in mouse after 4 h postinjection of radiolabeled peptide. 99mTc-HYNIC-(tricine)-(Ser)3-LTVPWY peptide exhibited overexpressed HER2 tumor targeting.
Using the Communication Methods, Tools and Support During Management of Project Communication in Industrial Manufacturing Enterprises
Authors: Samáková Jana , Babčanová Dagmar , Hrablikchovanová Henrieta , Mesárošová Jana , Šujanová Jana 
Published: February 2018

Abstract
Effective communication is the most significant ability for project manager and successful project. However, during the management of projects communication, it is very often forgotten, often overlooked or taken for granted. In the management of projects, it is principally necessary to deal with communication during all project lifecycle. Within the project communication, it is very important to define the main methods, tools, support of communication and frequency of communication; these belong to the most important elements of the communication channel which is very often forgotten. Therefore, the main aim of the paper is to analyse the utilisation of the communication channel: communication methods, communication tools, communication frequency and to support project communication in industrial manufacturing enterprises in Slovakia. Based on the research, we can conclude that communication channel is not adequately elaborated in international methodologies and standards of project management as well as in industrial manufacturing enterprises. These facts are very negative, conclusion and it is therefore necessary to deal with the problem.
Digitalisierung – Management Zwischen 0 und 1
Authors: Friedrich Stefan , Rachholz Josef 
Published: February 2018

Abstract
Digitization as a process of expressing actions and values by codes 0 and 1 has already has become part of our lives. Digitization enables enterprises to improve production, sales and to increase volume of production. However, no standard digitization strategy has been yet developed. Even in the digitized business process management system, the most important position remains to a human being. The improvement of software products, their availability and the education system in the area of introduction and use of information technology is thus a striking feature in development of managing (but also other) current processes.
Sluicing, Sprouting and Missing Objects
Authors: Li Yen-Hui Audrey , Wei Ting-Chi 
Published: February 2018

AbstractTaking “sluicing” to be derived by movement + deletion, as represented by Merchant (2001), and “pseudo-sluicing” to be a base-generated structure [pro(+be) +wh] (going by Wei 2004; Adams 2004), this paper reviews arguments for and against the presence of a sluicing construction in Mandarin Chinese. We show that all the tests available in the literature do not argue against the presence of such a sluicing construction, except the test building on the distribution of the copulashi. Unfortunately, theshitest is demonstrated to be uncertain and it cannot be used to argue conclusively that only a base-generation pseudo-sluicing analysis should be adopted. We show that a much clear evidence for an exclusive pseudo-sluicing analysis comes from the behavior of the sprouting construction. Investigation of sprouting also sheds light on the properties of null arguments, topic-variable relation, locality, and subcategorization of verbs in the language.
Developing polymer composite-based leaf spring systems for automotive industry
Authors: Oztoprak Nahit , Gunes Mehmet Deniz , Tanoglu Metin , Aktas Engin , Egilmez Oguz Ozgur , Senocak Ciler , Kulac Gediz 
Published: February 2018

Abstract
Composite-based mono-leaf spring systems were designed and manufactured to replace existing mono-leaf metal leaf spring in a light commercial vehicle. In this study, experimentally obtained mechanical properties of different fiber-reinforced polymer materials are presented first, followed by the description of the finite element analytical model created in Abaqus 6.12-1 (Dassault Systemes Simulia Corp., RI, US) using the obtained properties. The results from the finite element analysis are presented next and compared with actual size experimental tests conducted on manufactured prototypes. The results demonstrated that the reinforcement type and orientation dramatically influenced the spring rate. The prototypes showed significant weight reduction of about 80% with improved mechanical properties. The hybrid composite systems can be utilized for composite-based leaf springs with considerable mechanical performance.
Partner Notification for Gonorrhea and Syphilis in Belgrade
Authors: Bjekić Milan , Vlajinac Hristina 
Published: February 2018

Abstract
“Contact tracing” or “partner notification” refers to clinicians’ efforts to identify sex partners of infected persons to ensure their medical evaluation and treatment. For many years partner notification has been a cornerstone in the management of patients diagnosed with sexually transmitted infections (STIs) and it is the essential component in the control of these infections. Clinicians’ efforts to ensure the treatment of a patient’s sex partners can reduce the risk for re-infection and potentially diminish transmission of STIs. Partner notification includes three different approaches for notifying the sexual partners of the person infected with a STI: provider referral, patient referral, and contract referral. The aim of our study was to evaluate the efficacy of partner notification among syphilis and gonorrhea cases registered at the City Institute for Skin and Venereal Diseases in Belgrade in 2016, and its contribution to prevention and control of these diseases. A retrospective chart review of patients with gonorrhea and early syphilis registered in 2016 was undertaken. We analyzed data about the possible source of infection as well as sexual orientation, provided on the official form for notification of syphilis and gonorrhea. The study included 112 male patients, 67 with gonorrhea and 45 with syphilis. Out of three modalities of partner notification offered to patients, only patient notification of sexual partner/s was accepted. Although all patients accepted this type of partner notification, index patients with gonorrhea notified only 17 partners (25.4%) and index patients with syphilis also notified 17 partners (37.8%). The effectiveness of partner notification for gonorrhea and syphilis cases was only 30.4%, and its contribution to prevention and control of these diseases was lower than we expected. National guidelines offering standardized protocols for partner notification service provision can improve this process, as a novel approach with non-traditional method of partner notification such as patient-delivered partner therapy.
Primary Cutaneous Diffuse Large B-Cell Lymphoma – a Case Report
Authors: Milovanović Milena , Mijušković Željko , Kandolf Sekulović Lidija , Radić-Tasić Olga , Tarabar Olivera , Mijušković-Janković Danijela , Rajović Milica 
Published: February 2018

Abstract
In 2005, the World Health Organization - European Organization for Research and Treatment of Cancer (WHOEORTC) classified cutaneous B-cell lymphomas into 4 categories: primary cutaneous marginal zone B-cell lymphoma (PCMZL), primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), and primary cutaneous diffuse large B-cell lymphoma, other (PCDLBCL-O). The absence of evident extra-cutaneous disease is a necessary condition for the diagnosis of primary cutaneous B-cell lymphomas, because they have a completely different clinical behavior and prognosis from their nodal counterparts. PCDLBCL-O basically represents a morphological variation, lacking the typical features of PCDLBCLLT, neither confirming the definition of PCFCCL, but on the clinical ground, its behavior seems at least to partially overlap the indolent course of PCFCCL. In fact, the present WHO lymphoma classification from 2008 overcame the previous WHO-EORTC classification, including at least a part of PCDLBCL-O within the spectrum of PCFCCL. However, owing to the rarity and heterogeneity of the PCDLBCL-O, the precise clinicopathological characteristics have not been well characterized and the optimal treatment for this group of lymphomas is yet to be defined. Nevertheless, dermatologists and pathologists should be aware of this entity in order to avoid unnecessary aggressive treatment. We present a case of a 46-year-old Caucasian male with one large round-shaped tumor and a few scattered nodules localized on the back. The histopathological features of the lesion corresponded to PCDLBCL-O. The patient follow-up showed that he was disease-free three months after surgical excision of the lesions and adjuvant local radiotherapy. No additional therapy was introduced, including chemotherapy with rituximab, cyclophosphamide, doxorubicin hydrochloride, oncovin, prednisolone (R-CHOP).
Simplified Graphical Domain-Specific Languages as Communication Tools in the Process of Developing Mobile Systems for Reporting Life-Threatening Situations – the Perspective of Technical Persons
Authors: Żyła Kamil 
Published: February 2018

AbstractReporting systems based on mobile technologies and feedback from regular citizens are becoming increasingly popular, especially as far as protection of environmental and cultural heritage is concerned. Reporting life-threatening situations, such as sudden natural disasters or traffic accidents, belongs to the same class of problems and could be aided by IT systems of a similar architecture. Designing and developing systems for reporting life-threatening situations is not a trivial task, requiring close cooperation between software developers and experts in different domains, who could possibly find industrially recognized languages and notations difficult. Thus, the question is whether using simplified graphical domain-specific languages (SGDSLs) could help in creating a common communication platform. It has been revealed that domain experts have a preference for such languages as they offer good learnability, readability and ability to focus on the idea of application. The perspective of developers (technical persons) is introduced on the basis of feedback obtained from 84 students of Computer Science at the Lublin University of Technology, who attended comprehensive workshops followed by an anonymous survey. All participants received theoretical and practical training in modeling mobile software using the same set of languages as domain experts. An analysis of the results revealed that opinions expressed by technical and nontechnical persons concerning SGDSLs oriented on defining a flow of actions is consistent. Most respondents claimed that such languages might be valuable as tools for creating a common communication platform.
Distance Learning Methods in Continuing Education of Paramedics
Authors: Leszczyński Piotr , Charuta Anna , Gotlib Joanna , Kołodziejczak Barbara , Roszak Magdalena , Zacharuk Tamara 
Published: February 2018

Abstract
The process of continuing education of paramedics is based on gaining educational credits during five-year educational periods. One of the forms of self-improvement are Internet-based educational programs. The lack of regulations concerning the organizational and technical aspects of e-learning made the authors attempt to analyze the phenomenon. The aim of the article is to present an initial analysis of the role of online educational programs in comparison with other forms of professional training of paramedics. One in three respondents has recently used one of the methods of distance learning. Despite the low awareness of the effectiveness of e-learning, almost 70% of the interviewees expressed a positive opinion about it and over 50% were willing to use such forms in the future. The respondents preferred online trainings in the asynchronous version, containing audio-visual materials and providing the possibility to obtain a certificate issued to the participant after completing the course. The demand for topics in the area of professional training included mainly the fields of Drug Therapy, electrotherapy, electrocardiogram (ECG) evaluation, medical segregation, and help in delivery in pre-hospital conditions. Modern forms of distance learning do not make it possible to acquire practical skills, yet their role in professional training of paramedics is still significant. According to the authors, online educational programs constitute an effective complement to traditional training through the performance of tasks in a mixed form, known as blended-learning.
Determining the Shape Factor for Bend Torque
Authors: Křístek Ivo , Havlík Jiři , Mosler Václav , Daniš Igor , Pilc Jozef 
Published: February 2018

AbstractThis article is focused on creating diagrams to determine the shape factor α. Its significance for the use of the design components. And the experimental determination curves diagrams comparing the previously used charts and monograms. The beginning of the development of appropriate calculation methods for determining courses of stress concentration factor for individual notches, with the previously used charts.
Triaxial X-Ray Diffraction Method and its Application to Monitor Residual Stress in Surface Layers after High-Feed Milling
Authors: Zaušková Lucia , Czán Andrej , Šajgalík Michal , Pobijak Jozef , Mikloš Matej 
Published: February 2018

AbstractHigh-feed milling is a milling method characteristic with shallow depth of cut and high feed rate to maximize the amount of removed metal from a part, generating residual stresses in the surface and subsurface layers of the machined parts. The residual stress has a large influence on the functional properties of the components. The article is focused on the application of triaxial x-ray diffraction method to monitor residual stresses after high feed milling. Significance of triaxial measuring method is the capability of measuring in different angles so it is possible to acquire stress tensor containing normal and shear stress components.