bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting functional neuroanatomical maps from fusing brain networks with genetic information
Authors: Ganglberger Florian , Kaczanowska Joanna , Penninger Josef M. , Hess Andreas , Bühler Katja , Haubensak Wulf 
Published: August 2016

SummaryA central aim, from basic neuroscience to psychiatry, is to resolve how genes control brain circuitry and behavior. This is experimentally hard, since most brain functions and behaviors are controlled by multiple genes. In low throughput, one gene at a time, experiments, it is therefore difficult to delineate the neural circuitry through which these sets of genes express their behavioral effects. The increasing amount of publicly available brain and genetic data offers a rich source that could be mined to address this problem computationally. However, most computational approaches are not tailored to reflect functional synergies in brain circuitry accumulating within sets of genes. Here, we developed an algorithm that fuses gene expression and connectivity data with functional genetic meta data and exploits such cumulative effects to predict neuroanatomical maps for multigenic functions. These maps recapture known functional anatomical annotations from literature and functional MRI data. When applied to meta data from mouse QTLs and human neuropsychiatric databases, our method predicts functional maps underlying behavioral or psychiatric traits. We show that it is possible to predict functional neuroanatomy from mouse and human genetic meta data and provide a discovery tool for high throughput functional exploration of brain anatomyin silico.
A novel quantile regression approach for eQTL discovery
Authors: Song Xiaoyu , Li Gen , Ionita-Laza Iuliana , Wei Ying 
Published: August 2016

AbstractOver the past decade, there has been a remarkable improvement in our understanding of the role of genetic variation in complex human diseases, especially via genome-wide association studies. However, the underlying molecular mechanisms are still poorly characterized, impending the development of therapeutic interventions. Identifying genetic variants that influence the expression level of a gene, i.e. expression quantitative trait loci (eQTLs), can help us understand how genetic variants influence traits at the molecular level. While most eQTL studies focus on identifying mean effects on gene expression using linear regression, evidence suggests that genetic variation can impact the entire distribution of the expression level. Indeed, several studies have already investigated higher order associations with a special focus on detecting heteroskedasticity. In this paper, we develop a Quantile Rank-score Based Test (QRBT) to identify eQTLs that are associated with the conditional quantile functions of gene expression. We have applied the proposed QRBT to the Genotype-Tissue Expression project, an international tissue bank for studying the relationship between genetic variation and gene expression in human tissues, and found that the proposed QRBT complements the existing methods, and identifies new eQTLs with heterogeneous effects genome-wideacross different quantile levels. Notably, we show that the eQTLs identified by QRBT but missed by linear regression are more likely to be tissue specific, and also associated with greater enrichment in genome-wide significant SNPs from the GWAS catalog. An R package implementing QRBT is available on our website.
Pervasive correlated evolution in gene expression shapes cell type transcriptomes
Authors: Liang Cong , Musser Jacob M. , Cloutier Alison , Prum Richard O. , Wagner Günter P. 
Published: August 2016

AbstractThe evolution and diversification of cell types is a key means by which animal complexity evolves. Recently, hierarchical clustering and phylogenetic methods have been applied to RNA-seq data to infer cell type evolutionary history and homology. A major challenge for interpreting this data is that cell type transcriptomes may not evolve independently due to correlated changes in gene expression. This non-independence can arise for several reasons, such as when different tissues share common regulatory sequences for regulating genes expressed in multiple tissues, i.e. pleiotropic effects of mutations. We develop a model to estimate the level of correlated transcriptome evolution (LCE) and apply it to different datasets. The results reveal pervasive correlated transcriptome evolution among different cell and tissue types. In general, tissues related by morphology or developmental lineage exhibit higher LCE than more distantly related tissues. Analyzing new data collected from bird skin appendages suggests that LCE decreases with the phylogenetic age of tissues compared, with recently evolved tissues exhibiting the highest LCE. Furthermore, we show correlated evolution can alter patterns of hierarchical clustering, causing different tissue types from the same species to cluster together. Using a dataset with sufficient taxon sampling, we performed a gene-wise estimation of LCE, identifying genes that most strongly contribute to the correlated evolution signal. Removing genes with high LCE allows for accurate reconstruction of evolutionary relationships among tissue types. Our study provides a statistical method to measure and account for correlated gene expression evolution when interpreting comparative transcriptome data.
Internal states drive nutrient homeostasis by modulating exploration-exploitation trade-off
Authors: Corrales-Carvajal Verónica María , Faisal Aldo A , Ribeiro Carlos 
Published: August 2016

AbstractInternal states can deeply alter the behavior of animals. Which aspects of behavior change upon metabolic challenges and how these allow the animal to achieve nutrient homeostasis is poorly understood. We used an automated video tracking setup to characterize how amino acid and reproductive states interact to shape exploitation and exploration decisions taken by adultDrosophila melanogaster, to achieve nutritional homeostasis. We find that these two states have specific effects on the decisions to engage and leave proteinaceous food patches. Furthermore, the internal nutrient state defines the exploration-exploitation trade-off: nutrient deprived flies focus on specific patches while satiated flies explore more globally. Finally, we show that olfaction mediates the efficient recognition of yeast as an appropriate protein source and that octopamine is specifically required to mediate homeostatic postmating responses without affecting internal nutrient sensing. Internal states therefore modulate specific aspects of exploitation and exploration to change nutrient selection.
Dairy production diagnosis in Santa Catarina, Brazil, from the perspective of business ecosystem
Authors: Bonamigo Andrei , Ferenhof Helio Aisenberg , Forcellini Fernando Antonio 
Published: August 2016

Purpose
The purpose of this paper is to diagnose the barriers of dairy production system of Santa Catarina from the perspective of the business ecosystem concept.

Design/methodology/approach
The study consists of a bibliographic systematic review of the dairy production from the perspective of the business ecosystem. To analyze the resulting portfolio, the authors used the content analysis proposed by Bardin (2011), which served as the basis for analysis and discussion of the barriers of dairy production.

Findings
The authors identified a total of 19 barriers related with dairy production activity in Santa Catarina, they are properly presented and discussed. In addition, some ways to mitigate these barriers.

Research limitations/implications
This study may not have enabled a complete coverage of all existing peer-reviewed articles in the field of dairy production. Yet, it seems reasonable to assume that the review process covered a large proportion of studies available.

Originality/value
It is the first study that identifies barriers to the development of dairy production in Santa Catarina using as an analytical lens the business ecosystem. And once identified these barriers, it is possible to devise strategies to eliminate or mitigate these barriers.
Reducing waste of food left on plates
Authors: Mirosa Miranda , Munro Harriet , Mangan-Walker Ella , Pearson David 
Published: August 2016

PurposeSocial marketing and other types of targeted behaviour change interventions should appeal to an individual’s personal values in order to improve their effectiveness. However, there is currently little understanding of what these values are in relation to food waste. The purpose of this paper is to identify the values underpinning the specific behaviour of plate waste created in a residential foodservice setting.Design/methodology/approachIn semi-structured interviews (n=50) laddering techniques were used to identify links from behaviours through individual’s rationalisation for that behaviour to their personal values. The aim of the questioning was to uncover underlying drivers that lead to plate waste as well as those barriers to reducing it.FindingsThe values identified as being most important are hedonism and self-direction. The specific aspects of these values for plate waste reduction interventions are not compromising on the individual’s enjoyment of the meal and meeting their health goals. Effective interventions include pre-ordering meals, reducing food options provided, reducing plate size, removing food tray and finally, information campaigns to raise awareness.Originality/valueThe study provides insights into the personal values that influence behaviours resulting in plate waste. The study is the first to determine the links between this behaviour, rationalisations for that behaviour and personal values.
Consumer preference and demand for traceable food attributes
Authors: Lu Jiao , Wu Linhai , Wang Shuxian , Xu Lingling 
Published: August 2016

Purpose
The purpose of this paper with pork as a case is to analyze Chinese consumer preference and demand for traceable food attributes, in order to provide a useful reference for Chinese Government in developing the safe food market and preventing food safety risks.

Design/methodology/approach
This research surveyed 1,380 consumers in seven pilot cities that designated by the Chinese Ministry of Commerce for the construction of a meat and vegetable circulation traceability system. A choice-based conjoint analysis and multinomial logit model were used to study consumer preferences and demand for traceable pork attributes.

Findings
The results demonstrated that certification of traceable information was the most important characteristic, followed by appearance and traceable information. Significant heterogeneity was obtained in consumer preferences for the attributes of traceable pork. Also, consumers’ preferences for traceable attributes were memorably influenced by age, education level, and income level.

Social implications
Based on these results, the government should encourage and support the production of traceable food with different certification types and different traceability levels. Meanwhile, the development of food traceability systems should be combined with a quality certification labeling system.

Originality/value
This study extends the applicability of the setting of traceable food attributes and levels in China, and it will improve Chinese food traceability systems through multilateral cooperation.
Fats in ready-to-eat foods sold at Korean major amusement parks
Authors: Lee Yu-Mi , Lee Na-Young , Chung Myung-Sub , Ha Sang-Do , Bae Dong-Ho 
Published: August 2016

PurposeThe purpose of this paper is to analyze the fat, saturated fatty acid and trans fatty acid contents in ready-to-eat foods distributed at amusement parks to develop an appropriate food safety management system for children.Design/methodology/approachIn all, 322 ready-to-eat food samples categorized into 17 types were collected from nine Korean amusement parks and their fat, saturated fatty acid and trans fatty acid contents were assessed.FindingsFat, saturated fatty acid and trans fatty acid contents were relatively high in flour-based products. On the basis of the Korea Food and Drug Administration classification, the samples in 12 categories were classified as high-fat foods. The samples in nine categories were classified as high-saturated fatty acid foods. Most samples also contained non-negligible levels of trans fatty acids. The fat, saturated fatty acid and trans fatty acid contents of samples even in the same category varied markedly.Social implicationsThis research will inform the necessity of an appropriate safety management system for ready-to-eat foods distributed at amusement.Originality/valueAlthough the fat contents of foods distributed around school area were often observed, the potential risk of those in ready-to-eat foods distributed at amusement parks have rarely been assessed. As patterns of food intakes vary world-widely, a periodic monitoring data like this study may be useful for international organizations and researchers.
Role of trusting beliefs in predicting purchase intentions
Authors: Sahi Gurjeet Kaur , Sekhon Harjit Singh , Quareshi Tahira Khanam 
Published: August 2016

Purpose
India’s retail sector is going through a significant transitional period with the internet as a new distribution channel becoming more common. Given the barriers to adoption, the purpose of this paper is to understand the role played by trusting beliefs when engaging with an online retailer. In the Indian market, online vending is expected to increase at a rate of 35 per cent per annum, and by understanding trusting beliefs retailers will be able to develop their market share by developing appropriate and/or innovative strategies.

Design/methodology/approach
The work is based on a sample of more than 200 internet customers in India. In understanding the data and the relationships that emerged from the modelling, the authors used a range of tools to analyse the data, including CFA and structural equation modelling. The authors also used descriptive statistics to provide a holistic overview of response profiles.

Findings
The study reveals that trusting beliefs are negatively influenced by an uncertainty avoidance culture and positively influenced by a firm’s image and a customer’s price awareness. Moreover, purchase intentions (PIs) are significantly enhanced by trusting beliefs in an online environment. Hence, it leads us to conclude that PIs can be augmented by facilitating and ensuring good quality service by placing special emphasis on timeliness, accuracy and conditions of the order, security and privacy paradigms, aftersales services, etc.

Research limitations/implications
As can be seen, the internet is an emergent tool for retailers in India. By understanding trusting beliefs, retailers will be able to better understand customers’ behaviour and thus design management strategies accordingly. Although this is likely to take more than a decade, as internet retailing becomes embedded it may have a detrimental effect on the historical channel to market, thus altering the country’s retail landscape which is currently dominated by small retailers.

Practical implications
The work’s findings are insightful for those seeking to maximize the opportunities presented by the internet as a channel to market. The works shows how the channel is influenced and thus how it can be managed. In making the contribution the authors provide guidance in terms of operational activity to engage with potential customers.

Originality/value
This paper examines trusting beliefs when using the internet as a channel to market and in doing so it makes a new contribution because it establishes links with culture and other factors. For the research venue the authors use a developing market and therefore the findings are applicable to markets with similar characteristics.
Systematic review with meta‐analysis: the gastrointestinal benefits of COX‐2 selective inhibitors with concomitant use of low‐dose aspirin
Authors: Yuan J. Q. , Yang M. , Threapleton D. E. , Qi X. S. , Ye D. Q. , Mao C. , Tang J. L. , Higgins J. P. T. 
Published: August 2016

SummaryBackgroundIt is uncertain whether concurrent use of low‐dose aspirin removes the gastrointestinal benefit displayed by COX‐2 selective inhibitors (coxibs) when compared to traditional nonsteroidal anti‐inflammatory drugs (NSAIDs).AimTo evaluate the gastrointestinal risks associated with coxibs and traditional NSAIDs and the interaction with concurrent use of low‐dose aspirin.MethodsWe searched MEDLINE, EMBASE and the Cochrane Library through April 2016 to identify randomised trials comparing the gastrointestinal risk between coxibs and traditional NSAIDs in patients taking or not taking low‐dose aspirin. Results were combined using random effects meta‐analysis. Subgroup analyses by concurrent use of aspirin were undertaken.ResultsEleven trials (84 150 participants) were included. The overall relative risk (RR) of coxibs vs. traditional NSAIDs for complicated gastrointestinal events was 0.54 (95% CI, confidence interval 0.32–0.92), with a significant subgroup difference (P = 0.04) according to concurrent use of aspirin (used: RR = 0.96, 95% CI 0.66–1.24; not used: RR = 0.33, 95% CI 0.14–0.83). The overall RR for clinical gastrointestinal events was 0.59 (95% CI 0.47–0.75), with a significant subgroup difference according to aspirin usage (P = 0.008; used: RR = 0.77, 95% CI 0.62–0.95; not used: RR = 0.50, 95% CI 0.39–0.64). Overall coxibs were associated with significantly lower risk of symptomatic ulcers (RR = 0.60, 95% CI 0.50–0.72) and endoscopic ulcers (RR = 0.29, 95% CI 0.16–0.53) than traditional NSAIDs; a significant subgroup difference was shown for endoscopic ulcers (P = 0.05) but not for symptomatic ulcers (P = 0.27).ConclusionConcomitant use of low‐dose aspirin reduces but does not completely eliminate the gastrointestinal benefit of coxibs over traditional NSAIDs.
Mitochondrial uncoupler carbonyl cyanide m‐chlorophenylhydrazone induces vasorelaxation without involving KATP channel activation in smooth muscle cells of arteries
Authors: Zhang Yan‐Qiu , Shen Xin , Xiao Xiao‐Lin , Liu Ming‐Yu , Li Shan‐Liang , Yan Jie , Jin Jing , Gao Jin‐Lai , Zhen Chang‐Lin , Hu Nan , Zhang Xin‐Zi , Tai Yu , Zhang Liang‐Shuan , Bai Yun‐Long , Dong De‐Li 
Published: August 2016

Background and PurposeThe effects and mechanisms of chemical mitochondrial uncouplers on vascular function have never been identified. Here, we characterized the effects of the typical mitochondrial uncoupler carbonyl cyanide m‐chlorophenylhydrazone (CCCP) on vascular function in rat mesenteric arteries and aorta and elucidated the potential mechanisms.Experimental ApproachIsometric tension of mesenteric artery and thoracic aorta was recorded by using a multiwire myograph system. Protein levels were measured by western blot analyses. Cytosolic [Ca2+]i, mitochondrial ROS (mitoROS) and mitochondrial membrane potential of smooth muscle cells (A10) were measured by laser scanning confocal microscopy.Key ResultsAcute treatment with CCCP relaxed phenylephrine (PE)‐ and high K+ (KPSS)‐induced constriction of rat mesenteric arteries with intact and denuded endothelium. Pretreatment with CCCP prevented PE‐ and KPSS‐induced constriction of rat mesenteric arteries with intact and denuded endothelium. Similarly, CCCP prevented PE‐ and KPSS‐induced constriction of rat thoracic aorta. CCCP increased the cellular ADP/ATP ratio in vascular smooth muscle cells (A10) and activated AMPK in A10 cells and rat thoracic aorta tissues. CCCP‐induced aorta relaxation was attenuated in AMPK α1 knockout (−/−) mice. SERCA inhibitors thapsigargin and cyclopiazonic acid (CPA) but not the KATP channel blocker glibenclamide partially inhibited CCCP‐induced vasorelaxation in endothelium‐denuded rat mesenteric arteries. CCCP increased cytosolic [Ca2+]i, mitoROS production and depolarized mitochondrial membrane potential in A10 cells. FCCP, the analogue of CCCP, had similar vasoactivity as CCCP in rat mesenteric arteries.Conclusions and ImplicationsCCCP induces vasorelaxation by a mechanism that does not involve KATP channel activation in smooth muscle cells of arteries.
Early childhood development: impact of national human development, family poverty, parenting practices and access to early childhood education
Authors: Tran T. D. , Luchters S. , Fisher J. 
Published: August 2016

AbstractBackgroundThis study was to describe and quantify the relationships among family poverty, parents' caregiving practices, access to education and the development of children living in low‐ and middle‐income countries (LAMIC).MethodsWe conducted a secondary analysis of data collected in UNICEF's Multiple Indicator Cluster Surveys (MICS). Early childhood development was assessed in four domains: language‐cognitive, physical, socio‐emotional and approaches to learning. Countries were classified into three groups on the basis of the Human Development Index (HDI).ResultsOverall, data from 97 731 children aged 36 to 59 months from 35 LAMIC were included in the after analyses. The mean child development scale score was 4.93 out of a maximum score of 10 (95%CI 4.90 to 4.97) in low‐HDI countries and 7.08 (95%CI 7.05 to 7.12) in high‐HDI countries. Family poverty was associated with lower child development scores in all countries. The total indirect effect of family poverty on child development score via attending early childhood education, care for the child at home and use of harsh punishments at home was −0.13 SD (77.8% of the total effect) in low‐HDI countries, −0.09 SD (23.8% of the total effect) in medium‐HDI countries and −0.02 SD (6.9% of the total effect) in high‐HDI countries.ConclusionsChildren in the most disadvantaged position in their societies and children living in low‐HDI countries are at the greatest risk of failing to reach their developmental potential. Optimizing care for child development at home is essential to reduce the adverse effects of poverty on children's early development and subsequent life.
Evaluation of the maxillofacial morphological characteristics of Apert syndrome infants
Authors: Kakutani Hitomi , Sato Yoshiaki , Tsukamoto‐Takakusagi Yuri , Saito Fumio , Oyama Akihiko , Iida Junichiro 
Published: August 2016

AbstractApert syndrome is a rare craniosynostosis syndrome characterized by irregular craniosynostosis, midface hypoplasia, and syndactyly of the hands and feet. Previous studies analyzed individuals with Apert syndrome and reported some facial and intraoral features caused by severe maxillary hypoplasia. However, these studies were performed by analyzing both individuals who had and those had not received a palate repair surgery, which had a high impact on the maxillary growth and occlusion. To highlight the intrinsic facial and intraoral features of Apert syndrome, five Japanese individuals with Apert syndrome from 5 years and 2 months to 9 years and 10 months without cleft palate were analyzed in this study. A concave profile and a skeletal Class III jaw‐base relationship caused by severe maxillary hypoplasia were seen in all patients. The patients exhibited anterior and posterior crossbites possibly due to a small dental arch of Maxilla.