bluuebunny/crossref_metadata_2025_split huggingface dataset:
Further evidence for two metamorphic events in the Mawson Continent
Authors: Williams Megan A. , Kelsey David E. , Hand Martin , Raimondo Tom , Morrissey Laura J. , Tucker Naomi M. , Dutch Rian A. 
Published: December 2017

AbstractIn this study,in situand erratic samples from George V Coast (East Antarctica) and southern Eyre Peninsula (Australia) have been used to characterize the microstructural, pressure–temperature and geochronological record of upper amphibolite and granulite facies polymetamorphism in the Mawson Continent to provide insight into the spatial distribution of reworking and the subice geology of the Mawson Continent. Monazite U-Pb data shows thatin situsamples from the George V Coast record exclusively 2450–2400 Ma ages, whereas most erratic samples from glacial moraines at Cape Denison and the Red Banks Charnockite record only 1720–1690 Ma ages, consistent with known ages of the Sleaford and Kimban events, respectively. Phase equilibria forward modelling reveals considerable overlap of the thermal character of these two events. Samples with unimodal 1720–1690 Ma Kimban ages reflect either formation after the Sleaford event or complete metamorphic overprinting. Rocks recording only 2450–2400 Ma ages were unaffected by the younger Kimban event, perhaps as a result of unreactive rock compositions inherited from the Sleaford event. Our results suggest the subice geology of the Mawson Continent is a pre-Sleaford-aged terrane with a cover sequence reworked during the Kimban event.
Association ofCx43rs2071166 polymorphism with an increased risk for atrial septal defect
Authors: Gu Ruoyi , Sheng Wei , Ma Xiaojing , Huang Guoying 
Published: December 2017

AbstractAtrial septal defect is one of the most common CHD. The pathogenesis of atrial septal defect still remains unknown.Cx43is the most prevalent connexin in the mammalian heart during development. Its genetic variants can cause several CHD. The aim of our study was to investigate the association of genetic variations of theCx43with sporadic atrial septal defect. A total of 450 paediatric patients were recruited, including 150 cases with atrial septal defect and 300 healthy controls. The promoter region ofCx43was analysed by sequencing after polymerase chain reaction. All data were analysed by using the Statistic Package for Social Science 19.0 software. The frequency of the single nucleotide polymorphism rs2071166 was significantly higher in atrial septal defect cases than in healthy controls. The CC genotype at rs2071166 site inCx43was correlated with an increased risk for atrial septal defect (p<0.0001, odds ratio=3.891, 95% confidence interval 1.948–7.772) and the C allele was positively correlated with atrial septal defect (p=0.007, odds ratio=1.567, 95% confidence interval 1.129–2.175). In conclusion, our results confirmed that rs2071166 inCx43may be relevant with an increased atrial septal defect risk.
The global burden of paediatric heart disease
Authors: Musa Ndidiamaka L. , Hjortdal Vibeke , Zheleva Bistra , Murni Indah K. , Sano Shunji , Schwartz Steven , Staveski Sandra L. 
Published: December 2017

AbstractAn estimated 15 million children die or are crippled annually by treatable or preventable heart disease in low- and middle-income countries. Global efforts to reduce under-5 mortality have focused on reducing death from communicable diseases in low- and middle-income countries with little to no attention focusing on paediatric CHD and acquired heart disease. Lack of awareness of CHD and acquired heart disease, access to care, poor healthcare infrastructure, competing health priorities, and a critical shortage of specialists are important reasons why paediatric heart disease has not been addressed in low resourced settings. Non-governmental organisations have taken the lead to address these challenges. This review describes the global burden of paediatric heart disease and strategies to improve the quality of care for paediatric heart disease. These strategies would improve outcomes for children with heart disease.
Management of undernutrition and failure to thrive in children with congenital heart disease in low- and middle-income countries
Authors: Argent Andrew C. , Balachandran Rakhi , Vaidyanathan Balu , Khan Amina , Kumar R. Krishna 
Published: December 2017

AbstractPoor growth with underweight for age, decreased length/height for age, and underweight-for-height are all relatively common in children with CHD. The underlying causes of this failure to thrive may be multifactorial, including innate growth potential, severity of cardiac disease, increased energy requirements, decreased nutritional intake, malabsorption, and poor utilisation of absorbed nutrition. These factors are particularly common and severe in low- and middle-income countries.Although nutrition should be carefully assessed in all patients, failure of growth is not a contraindication to surgical repair, and patients should receive surgical repair where indicated as soon as possible.Close attention should be paid to nutritional support – primarily enteral feeding, with particular use of breast milk in infancy – in the perioperative period and in the paediatric ICU. This nutritional support requires specific attention and allocation of resources, including appropriately skilled personnel.Thereafter, it is essential to monitor growth and development and to identify causes for failure to catch-up or grow appropriately.
International quality improvement initiatives
Authors: Hickey Patricia A. , Connor Jean A. , Cherian Kotturathu M. , Jenkins Kathy , Doherty Kaitlin , Zhang Haibo , Gaies Michael , Pasquali Sara , Tabbutt Sarah , St. Louis James D. , Sarris George E. , Kurosawa Hiromi , Jonas Richard A. , Sandoval Nestor , Tchervenkov Christo I. , Jacobs Jeffery P. , Stellin Giovanni , Kirklin James K. , Garg Rajnish , Vener David F. 
Published: December 2017

AbstractAcross the globe, the implementation of quality improvement science and collaborative learning has positively affected the care and outcomes for children born with CHD. These efforts have advanced the collective expertise and performance of inter-professional healthcare teams. In this review, we highlight selected quality improvement initiatives and strategies impacting the field of cardiovascular care and describe implications for future practice and research. The continued leveraging of technology, commitment to data transparency, focus on team-based practice, and recognition of cultural norms and preferences ensure the success of sustainable models of global collaboration.
Paradigm Shifts in the Neuropsychology of Epilepsy
Authors: Hermann Bruce , Loring David W. , Wilson Sarah 
Published: December 2017

AbstractThis article reviews the major paradigm shifts that have occurred in the area of the application of clinical and experimental neuropsychology to epilepsy and epilepsy surgery since the founding of the International Neuropsychological Society. The five paradigm shifts discussed include: 1) The neurobiology of cognitive disorders in epilepsy – expanding the landscape of syndrome-specific neuropsychological impairment; 2) pathways to comorbidities: bidirectional relationships and their clinical implications; 3) discovering quality of life: The concept, its quantification and applicability; 4) outcomes of epilepsy surgery: challenging conventional wisdom; and 5) Iatrogenic effects of treatment: cognitive and behavioral effects of antiepilepsy drugs. For each area we characterize the status of knowledge, the key developments that have occurred, and how they have altered our understanding of the epilepsies and their management. We conclude with a brief overview of where we believe the field will be headed in the next decade which includes changes in assessment paradigms, moving from characterization of comorbidities to interventions; increasing development of new measures, terminology and classification; increasing interest in neurodegenerative proteins; transitioning from clinical seizure features to modifiable risk factors; and neurobehavioral phenotypes. Overall, enormous progress has been made over the lifespan of the INS with promise of ongoing improvements in understanding of the cognitive and behavioral complications of the epilepsies and their treatment. (JINS, 2017,23, 791–805)
The Neuropsychology of Traumatic Brain Injury: Looking Back, Peering Ahead
Authors: Yeates Keith Owen , Levin Harvey S. , Ponsford Jennie 
Published: December 2017

AbstractThe past 50 years have been a period of exciting progress in neuropsychological research on traumatic brain injury (TBI). Neuropsychologists and neuropsychological testing have played a critical role in these advances. This study looks back at three major scientific advances in research on TBI that have been critical in pushing the field forward over the past several decades: The advent of modern neuroimaging; the recognition of the importance of non-injury factors in determining recovery from TBI; and the growth of cognitive rehabilitation. Thanks to these advances, we now have a better understanding of the pathophysiology of TBI and how recovery from the injury is also shaped by pre-injury, comorbid, and contextual factors, and we also have increasing evidence that active interventions, including cognitive rehabilitation, can help to promote better outcomes. The study also peers ahead to discern two important directions that seem destined to influence research on TBI over the next 50 years: the development of large, multi-site observational studies and randomized controlled trials, bolstered by international research consortia and the adoption of common data elements; and attempts to translate research into health care and health policy by the application of rigorous methods drawn from implementation science. Future research shaped by these trends should provide critical evidence regarding the outcomes of TBI and its treatment, and should help to disseminate and implement the knowledge gained from research to the betterment of the quality of life of persons with TBI. (JINS, 2017,23, 806–817)
Facilitating Autism Research
Authors: Fein Deborah , Helt Molly 
Published: December 2017

AbstractEarly autism research focused on behavior and cognition. In recent decades, the pace of research has accelerated, and advances in imaging and genetics have allowed the accumulation of biological data. Nevertheless, a coherent picture of the syndrome at either phenotypic or biological level has not emerged. We see two fundamental obstacles to progress in basic understanding of autism. First, the two defining features (impairment in social interactions and communication, and restricted, repetitive behaviors and interests) are historically seen as integrally related. Others hold that these two major traits are fractionable and must be studied independently, casting doubt on autism as a coherent syndrome. Second, despite much recent research on brain structure and function, environmental factors, and genetics/genomics, findings on the biological level have not generally aligned well with those on the phenotypic level. In the first two sections, we explore these challenges, and in the third section, we review approaches that may facilitate progress, such as (1) including in studies all individuals defined by social impairment without regard to repetitive behaviors, (2) forming narrowly defined subtypes by thorough characterization on specific features, both diagnostic and non-diagnostic, (3) focusing on characteristics that may be relatively robust to environmental influence, (4) studying children as early as possible, minimizing environmental influence, and including longitudinal course as an important part of the phenotype, (5) subtyping by environmental risk factors, (6) distinguishing between what participants can do and what they typically do, and (7) aggregating large data sets across sites. (JINS, 2017, 23, 903–915)
What Do Language Disorders Reveal about Brain–Language Relationships? From Classic Models to Network Approaches
Authors: Dronkers Nina F. , Ivanova Maria V. , Baldo Juliana V. 
Published: December 2017

AbstractStudies of language disorders have shaped our understanding of brain–language relationships over the last two centuries. This article provides a review of this research and how our thinking has changed over the years regarding how the brain processes language. In the 19th century, a series of famous case studies linked distinct speech and language functions to specific portions of the left hemisphere of the brain, regions that later came to be known as Broca’s and Wernicke’s areas. One hundred years later, the emergence of new brain imaging tools allowed for the visualization of brain injuriesin vivothat ushered in a new era of brain-behavior research and greatly expanded our understanding of the neural processes of language. Toward the end of the 20th century, sophisticated neuroimaging approaches allowed for the visualization of both structural and functional brain activity associated with language processing in both healthy individuals and in those with language disturbance. More recently, language is thought to be mediated by a much broader expanse of neural networks that covers a large number of cortical and subcortical regions and their interconnecting fiber pathways. Injury to both grey and white matter has been seen to affect the complexities of language in unique ways that have altered how we think about brain–language relationships. The findings that support this paradigm shift are described here along with the methodologies that helped to discover them, with some final thoughts on future directions, techniques, and treatment interventions for those with communication impairments. (JINS, 2017,23, 741–754)
Current nut recommendation practices differ between health professionals in New Zealand
Authors: Brown Rachel C , Gray Andrew R , Yong Lee Ching , Chisholm Alex , Leong Sook Ling , Tey Siew Ling 
Published: December 2017

AbstractObjectiveDespite evidence linking regular nut consumption with reduced chronic disease risk, population-level intakes remain low. Research suggests nut-promoting advice from doctors facilitates regular nut consumption. However, there is no information on current nut recommendation practices of health professionals. The aim of the present study was to examine the advice provided by health professionals regarding nut consumption.DesignIn this cross-sectional study, participants were invited to complete a survey including questions about their nut recommendation practices.SettingNew Zealand (NZ).SubjectsThe NZ Electoral Roll was used to identify dietitians, general practitioners and practice nurses.ResultsIn total 318 dietitians, 292 general practitioners and 149 practice nurses responded. Dietitians were more likely (82·7 %) to recommend patients increase consumption of nuts than general practitioners (55·5 %) and practice nurses (63·1 %; both P<0·001). The most popular nuts recommended were almonds, Brazil nuts and walnuts, with most health professionals recommending raw nuts. The most common recommendation for frequency of consumption by dietitians and practice nurses was to eat nuts every day, while general practitioners most frequently recommended 2–4 times weekly, although not statistically significantly different between professions. Dietitians recommended a significantly greater amount of nuts (median 30 g/d) than both general practitioners and practice nurses (20 g/d; both P<0·001).ConclusionsDietitians were most likely to recommend consumption of nuts in accordance with current guidelines, but there are opportunities to improve the adoption of nut consumption recommendations for all professions. This may be a viable strategy for increasing population-level nut intakes to reduce chronic disease.
Optimism and quality of life in patients with heart failure
Authors: Kraai I.H. , Vermeulen K.M. , Hillege H.L. , Jaarsma T. , Hoekstra T. 
Published: December 2017

AbstractObjectivesHealth-related quality of life (HR-QoL) of patients with heart failure (HF) is low despite the aim of HF treatment to improve HR-QoL. To date, most studies have focused on medical and physical factors in relation to HR-QoL, few data are available on the role of emotional factors such as dispositional optimism. This study examines the prevalence of optimism and pessimism in HF patients and investigates how optimism and pessimism are associated with different patient characteristics and HR-QoL.MethodsDispositional optimism was assessed in 86 HF patients (mean age 70 ± 9 years, 28% female, mean left ventricular ejection fraction 33%) with the Revised Life Orientation Test (LOT-R). HR-QoL was assessed with the Minnesota Living with Heart Failure Questionnaire and the EuroQol.ResultsThe (mean ± SD) total score on the LOT-R was 14.6 ± 2.9 (theoretical range 0–24) and the scores on the subscales optimism and pessimism were 8.1 ± 1.9 and 5.5 ± 2.5, respectively. Higher age was related to more optimism (r = 0.22, p < 0.05), and optimism was associated with higher generic HR-QoL (B = 0.04, p < 0.05).Significance of resultsThe association found between optimism and generic HR-QoL of HF patients can lead to promising strategies to improve HF patients’ HR-QoL, particularly because the literature has indicated that optimism is a modifiable condition.
Managing grazing lands to improve soils and promote climate change adaptation and mitigation: a global synthesis
Authors: DeLonge Marcia , Basche Andrea 
Published: December 2017

AbstractThe potential to improve soils to help farmers and ranchers adapt to and mitigate climate change has generated significant enthusiasm. Within this discussion, grasslands have surfaced as being particularly important, due to their geographic range, their capacity to store substantial quantities of carbon relative to cultivated croplands and their potential role in mitigating droughts and floods. However, leveraging grasslands for climate change mitigation and adaptation will require a better understanding of how farmers and ranchers who rely on them for their livelihoods can improve management and related outcomes. To investigate opportunities for such improvements, we conducted a meta-analysis of field experiments that investigated how soil water infiltration rates are affected by a range of management options: adding complexity to grazing patterns, reducing stocking rates or extended rest from grazing. Further, to explore the relationships between observed changes in soil water infiltration and soil carbon, we identified papers that reported data on both metrics. We found that in 81.9% of all cases, responses of infiltration rates to identified management treatments (response ratios) were above zero, with infiltration rates increasing by 59.3 ± 7.3%. Mean response ratios from unique management categories were not significantly different, although the effect of extended rest (67.9 ± 8.5%,n= 140 from 31 experiments) was slightly higher than from reducing stocking rates (42.0 ± 10.8%;n= 63 from 17 experiments) or adding complexity (34.0 ± 14.1%,n= 17 from 11 experiments). We did not find a significant effect of several other variables, including treatment duration, mean annual precipitation or soil texture; however, analysis of aridity indices suggested that grazing management may have a slightly larger effect in more humid environments. Within our database, we found that 42% of complexity studies, 41% of stocking rate studies and 29% of extended rest studies also reported at least some measure of soil carbon. Within the subset of cases where both infiltration rates and carbon were reported, response ratios were largely positive for both variables (at least 64% of cases had positive mean response ratios in all management categories). Overall, our findings reveal that a variety of management strategies have the potential to improve soil water infiltration rates, with possible benefits for soil carbon as well. However, we identified a shortage of well-replicated and detailed experiments in all grazing management categories, and call for additional research of both soil water and soil carbon properties for these critical agroecosystems.
The Empathic Process and Misconceptions that Lead to Burnout in Healthcare Professionals
Authors: Villacieros Marta , Olmos Ricardo , Bermejo José Carlos 
Published: December 2017

AbstractEmpathy has been identified as a relevant variable in order to predict burnout in healthcare professionals. In addition, assertiveness and self-esteem have been considered relevant variables to develop empathic capacity. In the other hand, misconceptions surrounding empathy constitute a risk factor for burnout. Two adult samples (N = 252 and N = 275) were used to explore and confirm the underlying structure of two questionnaires. The Exercise of Process of Empathy (EPE) scale (18 items) confirmatory factor analysis including 5 dimensions (cognitive and emotional comprehension, attention, clarity and assertiveness), showed reasonable goodness- of-fit indices χ2(130) = 269.63, p < .001; RMSEA = .069 90% CI [0.058 – 0.079]; CFI = .965; TLI = .959. Alpha coefficient resulted .848. Common Misconceptions (EH) of empathy scale (16 items) confirmatory factor analysis, including 3 dimensions (feeling, confluence and character misconceptions) also obtained reasonable goodness-of-fit indices χ2(101) = 250.59, p < .001; RMSEA = .075 90% CI [0.063 – 0.087]; CFI = .952; TLI = .943. Alpha coefficient for Character resulted .727 (5 items), for Confluence .764 (5 items) and for Feeling .822 (6 items). The SEM model’s R2 resulted .303, being EH (misconceptions) a risk factor (b* = .171), EPE (empathy process) a protection factor (b* = –.183). The model partially explains how misconceptions empathy process and self-esteem (b* = –.334) relate to burnout syndrome in healthcare professionals; what is more, it heralds a potential means to prevent it.
Teachers’ Perceived Disruption at School and Related Variables from Teachers and School Functioning
Authors: Martínez Fernández María Belén , Chacón Gómez José C. , Martín Babarro Javier , Díaz-Aguado Jalón María José , Martínez Arias Rosario 
Published: December 2017

AbstractThis study explores variables related to teachers’ perception of disruption at school as a function of teachers (sense of personal accomplishment, professional disengagement and depersonalization and emotional exhaustion) and school (overall school management and quality of school rules) factors. Using a questionnaire regarding school climate, data from 4,055 teachers across 187 high schools were analyzed. Hierarchical linear modeling was applied and the results indicate that, taken separately, significant individual teacher predictors (Model 1) explain 26% (95% CI [.23, .29]) of the variability of the perceived disruption, especially depersonalization and emotional exhaustion. Contextual school variables (Model 2) explained 15% (95% CI [.12, .18]) of variance in teachers’ perceived disruption, with a significant negative relationship with the quality of rules. Model 3 included the above factors plus interactions between the emotional exhaustion and depersonalization variables and school indicators (30% of variance explained; 95% CI [.26, .33]). The results indicated the existence of a moderating effect for the quality of school rules, so that fair and properly-applied rules in the school context may be associated with a decrease in the relationship between depersonalization and emotional exhaustion and perceived disruption.