bluuebunny/crossref_metadata_2025_split huggingface dataset:
Layer formation in sedimentary fingering convection
Authors: Reali J. F. , Garaud P. , Alsinan A. , Meiburg E. 
Published: March 2017

When particles settle through a stable temperature or salinity gradient they can drive an instability known as sedimentary fingering convection. This phenomenon is thought to occur beneath sediment-rich river plumes in lakes and oceans, in the context of marine snow where decaying organic materials serve as the suspended particles or in the atmosphere in the presence of aerosols or volcanic ash. Laboratory experiments of Houk & Green (Deep-Sea Res., vol. 20, 1973, pp. 757–761) and Green (Sedimentology, vol. 34(2), 1987, pp. 319–331) have shown sedimentary fingering convection to be similar to the more commonly known thermohaline fingering convection in many ways. Here, we study the phenomenon using three-dimensional direct numerical simulations. We find evidence for layer formation in sedimentary fingering convection in regions of parameter space where it does not occur for non-sedimentary systems. This is due to two complementary effects. Sedimentation affects the turbulent fluxes and broadens the region of parameter space unstable to the $\unicode[STIX]{x1D6FE}$-instability (Radko, J. Fluid Mech., vol. 497, 2003, pp. 365–380) to include systems at larger density ratios. It also gives rise to a new layering instability that exists in $\unicode[STIX]{x1D6FE}$-stable regimes. The former is likely quite ubiquitous in geophysical systems for sufficiently large settling velocities, while the latter probably grows too slowly to be relevant, at least in the context of sediments in water.
A Norwegian pillar in Svalbard: the development of the University Centre in Svalbard (UNIS)
Authors: Misund Ole A. , Aksnes Dag W. , Christiansen Hanne H. , Arlov Thor B. 
Published: March 2017

ABSTRACTThe University Centre in Svalbard (UNIS) is a unique institution with a history that is closely related to Norwegian policy regarding Svalbard, and to clever development of a highly specialised Arctic university institution by all the Norwegian universities. In practical terms, Norwegian sovereignty on the archipelago as confirmed by the Treaty of Svalbard of 1920 and regulated by the Svalbard Law of 1925, is maintained by the presence of Norwegian civil authorities and communities. Today, the “capital” Longyearbyen with its 2100 inhabitants is a modern hub for industry, education, research, logistics and tourism. Founded in 1993, UNIS has become a main contributor to this community, generating some 20% of the total economic activity. A prime motivation for establishing UNIS was to provide a supplement and alternative to the unprofitable, heavily subsidized coal mining industry, by using the location for research based education. In 2015, the mining company Store Norske Spitsbergen Kullkompani (SNSK) met with deep crisis again and significantly downscaled its coal production and work force. Thus, UNIS may play an even more important role as a cornerstone of the local community in the future. This paper discusses the establishment and development of UNIS, its organisation, capacity, and academic production in terms of student graduation and its scientific output, just as its future potential for growth is evaluated. Finally, we discuss the increasingly important role of science and education in Norwegian Svalbard policy.
Passive revolution: a universal concept with geographical seats
Authors: Hesketh Chris 
Published: March 2017

AbstractIn this article, I argue that Antonio Gramsci’s concept of passive revolution makes a foundational contribution to International Relations (IR), yet has been relatively under appreciated by the broader discipline. Within the Historical Sociology of International Relations, uneven and combined development has recently been postulated as a key trans-historical law that provides a social theory of the ‘international’. Drawing from, but moving beyond these debates, I will argue that passive revolution is a key conditioning factor of capitalist modernity. I will demonstrate how the concept of passive revolution is the element that explains the connection between the universal process of uneven development and the manner in which specific combinations occur within the capitalist era as geopolitical pressures, in tandem with domestic social forces become internalised into geographically specific state forms. It therefore offers a corrective to the frequently aspatial view that is found in much of the literature in IR regarding uneven and combined development. Additionally, passive revolution provides a more politicised understanding of the present as well as an important theoretical lesson in relation to what needs to be done to affect alternative trajectories of development.
Effects of beam temperature and plasma frequency on the radiation growth rate of a FEL with a laser wiggler
Authors: Esmaeildoost N. , Jafari S. 
Published: March 2017

AbstractA linearly polarized laser pulse has been employed as a wiggler in a free-electron laser (FEL) in the presence of a plasma background for generating short wavelength radiation down to the extreme ultraviolet ray and X-ray spectral regions. Introducing plasma background in the FEL interaction region would lessen the beam energy requirement and also enhance both the beam current and the electron-bunching process. This configuration affords the possibility of scaling the device to more compact FELs and would have a higher tunability by changing the plasma density and the temperature of the electron beam. Electron trajectories have been analyzed using single-particle dynamics. The effect of plasma density on electron orbits has been investigated. A polynomial dispersion relation considering longitudinal thermal motion has been derived, by employing perturbation analysis. Numerical studies indicate that by increasing plasma density, the growth rate for groups I and II decreases, while the growth rate for group III increases. In addition, the effect of beam temperature and cyclotron frequency on the growth rate has been discussed. It has been found that by increasing the thermal velocity of the electron beam, the growth rate for groups I and III trivially decreases, while it increases for group II orbits. Besides, an increase in cyclotron frequency cause growth enhancement for group I orbits, while it present a growth decrement for group II and III orbits.
Epidemiology ofEscherichia coliserogroups O26, O103, O111 and O145 in very young (‘bobby’) calves in the North Island, New Zealand
Authors: IRSHAD H. , COOKSON A. L. , PRATTLEY D. J. , MARSHALL J. , FRENCH N. P. 
Published: March 2017

SUMMARYThe prevalence and spatial distribution ofEscherichia coliserogroups O26, O103, O111 and O145 in calves <7 days old in New Zealand and their relationship with serum IgG, weight and sex was determined by collecting recto-anal mucosal swabs (RAMS) (n= 299) and blood samples (n= 299) from two slaughter plants in the North Island. Real-time PCR of RAMS enrichment cultures revealed that 134/299 samples were positive for O26, 68/299 for O103 and 47/299 for O145, but none were positive for O111. Processing of positive enrichment cultures resulted in 49 O26, four O103 and five O145 isolates. Using multiplex PCR 25/49 (51%) O26 isolates were positive forstx1, eae, ehxA, 17/49 (34·7%) foreae, ehxAand 7/49 (14·2%) foreaeonly. All O103 and O145 isolates were positive foreae, ehxAonly. O26 isolates were grouped into four clusters (>70% similarity) using pulsed field gel electrophoresis. Mapping of the farms showed the presence of farms positive for O26, O103 and O145 in three important dairy producing regions of the North Island. Calves positive for O103 were more likely to be positive for O26 and vice versa (P= 0·04). Similarly, calves positive for O145 were more likely to be positive for O103 and vice versa (P= 0·03). This study demonstrates that non-O157E. coliserogroups of public health and economic importance containing clinically relevant virulence factors are present in calves in the North Island of New Zealand.
Extremely refractory Kawasaki disease with disseminated intravascular coagulation
Authors: Koh Young Kwon , Lee Jae Hee , Park Yeong Bong 
Published: March 2017

AbstractDisseminated intravascular coagulation is a rare complication of Kawasaki disease and appears in <0.1% of Kawasaki disease patients. We report a case of refractory Kawasaki disease complicated with disseminated intravascular coagulation and giant coronary aneurysm. A 5-month-old boy presented with Kawasaki disease with coagulopathy. Although the coagulopathy improved after fresh-frozen plasma and antithrombin-III administration, the fever persisted despite two rounds of intravenous immunoglobulin, along with intravenous methylprednisolone pulse therapy and infliximab administration. Despite all efforts to treatment, the patient had giant coronary aneurysms and died suddenly.
Find the errors, get the better: Enhancing machine translation via word confidence estimation
Authors: LUONG NGOC-QUANG , BESACIER LAURENT , LECOUTEUX BENJAMIN 
Published: March 2017

AbstractThis paper presents two novel ideas of improving the Machine Translation (MT) quality by applying the word-level quality prediction for the second pass of decoding. In this manner, the word scores estimated by word confidence estimation systems help to reconsider the MT hypotheses for selecting a better candidate rather than accepting the current sub-optimal one. In the first attempt, the selection scope is limited to the MTN-best list, in which our proposed re-ranking features are combined with those of the decoder for re-scoring. Then, the search space is enlarged over the entire search graph, storing many more hypotheses generated during the first pass of decoding. Over all paths containing words of theN-best list, we propose an algorithm to strengthen or weaken them depending on the estimated word quality. In both methods, the highest score candidate after the search becomes the official translation. The results obtained show that both approaches advance the MT quality over the one-pass baseline, and the search graph re-decoding achieves more gains (in BLEU score) thanN-best List Re-ranking method.
Explaining environmental health behaviors: evidence from rural India on the influence of discount rates
Authors: Atmadja Stibniati S. , Sills Erin O. , Pattanayak Subhrendu K. , Yang Jui-Chen , Patil Sumeet 
Published: March 2017

AbstractThe authors examine whether high personal discount rates help explain why and which households in developing countries under-invest in seemingly low-cost options to avert environmental health threats, including bednets, clean cooking fuels, individual household latrines, water treatment and handwashing. First, the authors elicit personal discount rates by combining a simple randomized experiment with detailed surveys of over 10,000 rural households in Maharashtra, India. Personal discount rates are lower for women, for better-off households, and for households who can access formal credit. Secondly, they show that the discount rate is negatively related to a suite of behaviors that mitigate environmental health threats, from very low-cost steps like washing hands to more significant investments like household latrines, even after controlling for socio-economic status, access to credit, public infrastructure and services, and relevant beliefs.
It's not about the gender binary, it's about the gender hierarchy: A reply to “Letting Go of the Gender Binary”
Authors: Ward Jeanne 
Published: March 2017

The “Debate” section of theReviewaims to contribute to the reflection on current ethical, legal, or operational controversies around humanitarian issues.In its issue on “Sexual Violence in Armed Conflict” (Vol. 96, No. 894, 2014), theReviewpublished an Opinion Note by Chris Dolan entitled “Letting Go of the Gender Binary: Charting New Pathways for Humanitarian Interventions on Gender-Based Violence”. In light of the review process for the Inter-Agency Standing Committee'sGuidelines for Integrating Gender-Based Violence Interventions in Humanitarian Action(GBV Guidelines), Dolan argues for a shift in the conceptualization of gender-based violence (GBV)in humanitarian settings from an emphasis on gender equality to an ethos of gender inclusivity. This, he suggests, is essential to improving the situation of victims, furthering social justice and changing agendas.In this issue, theReviewpresents the view of Jeanne Ward, one of the lead authors of the revised GBV Guidelines. For Ward, attempts to shift away from a focus on gender equality in GBV programming represent a regression rather than an advancement for the GBV field, as a dedicated spotlight on the rights and needs of women and girls continues to be hard-won in humanitarian contexts. Instead, she suggests retaining a focus on women and girls in GBV work, while moving forward in partnership with those who wish to accelerate programming directed to men and LGBTI communities broadly.
Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis
Authors: Bartell Jennifer A. , Blazier Anna S. , Yen Phillip , Thøgersen Juliane C. , Jelsbak Lars , Goldberg Joanna B. , Papin Jason A. 
Published: March 2017

AbstractVirulence-linked pathways in opportunistic pathogens are putative therapeutic targets that may be associated with less potential for resistance than targets in growth-essential pathways. However, efficacy of virulence-linked targets may be affected by the contribution of virulence-related genes to metabolism. We evaluate the complex interrelationships between growth and virulence-linked pathways using a genome-scale metabolic network reconstruction of Pseudomonas aeruginosa strain PA14 and an updated, expanded reconstruction of P. aeruginosa strain PAO1. The PA14 reconstruction accounts for the activity of 112 virulence-linked genes and virulence factor synthesis pathways that produce 17 unique compounds. We integrate eight published genome-scale mutant screens to validate gene essentiality predictions in rich media, contextualize intra-screen discrepancies and evaluate virulence-linked gene distribution across essentiality datasets. Computational screening further elucidates interconnectivity between inhibition of virulence factor synthesis and growth. Successful validation of selected gene perturbations using PA14 transposon mutants demonstrates the utility of model-driven screening of therapeutic targets.
Laser-Accelerated Proton Beams as Diagnostics for Cultural Heritage
Authors: Barberio M. , Veltri S. , Scisciò M. , Antici P. 
Published: March 2017

AbstractThis paper introduces the first use of laser-generated proton beams as diagnostic for materials of interest in the domain of Cultural Heritage. Using laser-accelerated protons, as generated by interaction of a high-power short-pulse laser with a solid target, we can produce proton-induced X-ray emission spectroscopies (PIXE). By correctly tuning the proton flux on the sample, we are able to perform the PIXE in a single shot without provoking more damage to the sample than conventional methodologies. We verify this by experimentally irradiating materials of interest in the Cultural Heritage with laser-accelerated protons and measuring the PIXE emission. The morphological and chemical analysis of the sample before and after irradiation are compared in order to assess the damage provoked to the artifact. Montecarlo simulations confirm that the temperature in the sample stays safely below the melting point. Compared to conventional diagnostic methodologies, laser-driven PIXE has the advantage of being potentially quicker and more efficient.
Crystal structures of highly simplified BPTIs provide insights into hydration-driven increase of unfolding enthalpy
Authors: Islam Mohammad Monirul , Yohda Masafumi , Kidokoro Shun-ichi , Kuroda Yutaka 
Published: March 2017

AbstractWe report a thermodynamic and structural analysis of six extensively simplified bovine pancreatic trypsin inhibitor (BPTI) variants containing 19–24 alanines out of 58 residues. Differential scanning calorimetry indicated a two-state thermal unfolding, typical of a native protein with densely packed interior. Surprisingly, increasing the number of alanines induced enthalpy stabilization, which was however over-compensated by entropy destabilization. X-ray crystallography indicated that the alanine substitutions caused the recruitment of novel water molecules facilitating the formation of protein–water hydrogen bonds and improving the hydration shells around the alanine’s methyl groups, both of which presumably contributed to enthalpy stabilization. There was a strong correlation between the number of water molecules and the thermodynamic parameters. Overall, our results demonstrate that, in contrast to our initial expectation, a protein sequence in which over 40% of the residues are alanines can retain a densely packed structure and undergo thermal denaturation with a large enthalpy change, mainly contributed by hydration.
Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography
Authors: Lan Gongpu , Li Guoqiang 
Published: March 2017

AbstractNonlinear sampling of the interferograms in wavenumber (k) space degrades the depth-dependent signal sensitivity in conventional spectral domain optical coherence tomography (SD-OCT). Here we report a linear-in-wavenumber (k-space) spectrometer for an ultra-broad bandwidth (760 nm–920 nm) SD-OCT, whereby a combination of a grating and a prism serves as the dispersion group. Quantitative ray tracing is applied to optimize the linearity and minimize the optical path differences for the dispersed wavenumbers. Zemax simulation is used to fit the point spread functions to the rectangular shape of the pixels of the line-scan camera and to improve the pixel sampling rates. An experimental SD-OCT is built to test and compare the performance of the k-space spectrometer with that of a conventional one. Design results demonstrate that this k-space spectrometer can reduce the nonlinearity error in k-space from 14.86% to 0.47% (by approximately 30 times) compared to the conventional spectrometer. The 95% confidence interval for RMS diameters is 5.48 ± 1.76 μm—significantly smaller than both the pixel size (14 μm × 28 μm) and the Airy disc (25.82 μm in diameter, calculated at the wavenumber of 7.548 μm−1). Test results demonstrate that the fall-off curve from the k-space spectrometer exhibits much less decay (maximum as −5.20 dB) than the conventional spectrometer (maximum as –16.84 dB) over the whole imaging depth (2.2 mm).
Formation and evolution of a pair of collisionless shocks in counter-streaming flows
Authors: Yuan Dawei , Li Yutong , Liu Meng , Zhong Jiayong , Zhu Baojun , Li Yanfei , Wei Huigang , Han Bo , Pei Xiaoxing , Zhao Jiarui , Li Fang , Zhang Zhe , Liang Guiyun , Wang Feilu , Weng Suming , Li Yingjun , Jiang Shaoen , Du Kai , Ding Yongkun , Zhu Baoqiang , Zhu Jianqiang , Zhao Gang , Zhang Jie 
Published: March 2017

AbstractA pair of collisionless shocks that propagate in the opposite directions are firstly observed in the interactions of laser-produced counter-streaming flows. The flows are generated by irradiating a pair of opposing copper foils with eight laser beams at the Shenguang-II (SG-II) laser facility. The experimental results indicate that the excited shocks are collisionless and electrostatic, in good agreement with the theoretical model of electrostatic shock. The particle-in-cell (PIC) simulations verify that a strong electrostatic field growing from the interaction region contributes to the shocks formation. The evolution is driven by the thermal pressure gradient between the upstream and the downstream. Theoretical analysis indicates that the strength of the shocks is enhanced with the decreasing density ratio during both flows interpenetration. The positive feedback can offset the shock decay process. This is probable the main reason why the electrostatic shocks can keep stable for a longer time in our experiment.
Nkx2.1 regulates the generation of telencephalic astrocytes during embryonic development
Authors: Minocha Shilpi , Valloton Delphine , Arsenijevic Yvan , Cardinaux Jean-René , Guidi Raffaella , Hornung Jean-Pierre , Lebrand Cécile 
Published: March 2017

AbstractThe homeodomain transcription factor Nkx2.1 (NK2 homeobox 1) controls cell differentiation of telencephalic GABAergic interneurons and oligodendrocytes. Here we show that Nkx2.1 also regulates astrogliogenesis of the telencephalon from embryonic day (E) 14.5 to E16.5. Moreover we identify the different mechanisms by which Nkx2.1 controls the telencephalic astrogliogenesis. In Nkx2.1 knockout (Nkx2.1−/−) mice a drastic loss of astrocytes is observed that is not related to cell death. Further, in vivo analysis using BrdU incorporation reveals that Nkx2.1 affects the proliferation of the ventral neural stem cells that generate early astrocytes. Also, in vitro neurosphere assays showed reduced generation of astroglia upon loss of Nkx2.1, which could be due to decreased precursor proliferation and possibly defects in glial specification/differentiation. Chromatin immunoprecipitation analysis and in vitro co-transfection studies with an Nkx2.1-expressing plasmid indicate that Nkx2.1 binds to the promoter of glial fibrillary acidic protein (GFAP), primarily expressed in astrocytes, to regulate its expression. Hence, Nkx2.1 controls astroglial production spatiotemporally in embryos by regulating proliferation of the contributing Nkx2.1-positive precursors.
Quantification of free-living activity patterns using accelerometry in adults with mental illness
Authors: Chapman Justin J. , Roberts James A. , Nguyen Vinh T. , Breakspear Michael 
Published: March 2017

AbstractPhysical activity is disrupted in many psychiatric disorders. Advances in everyday technologies – such as accelerometers in smart phones – opens exciting possibilities for non-intrusive acquisition of activity data. Successful exploitation of this opportunity requires the validation of analytical methods that can capture the full movement spectrum. The study aim was to demonstrate an analytical approach to characterise accelerometer-derived activity patterns. Here, we use statistical methods to characterize accelerometer-derived activity patterns from a heterogeneous sample of 99 community-based adults with mental illnesses. Diagnoses were screened using the Mini International Neuropsychiatric Interview, and participants wore accelerometers for one week. We studied the relative ability of simple (exponential), complex (heavy-tailed), and composite models to explain patterns of activity and inactivity. Activity during wakefulness was a composite of brief random (exponential) movements and complex (heavy-tailed) processes, whereas movement during sleep lacked the heavy-tailed component. In contrast, inactivity followed a heavy-tailed process, lacking the random component. Activity patterns differed in nature between those with a diagnosis of bipolar disorder and a primary psychotic disorder. These results show the potential of complex models to quantify the rich nature of human movement captured by accelerometry during wake and sleep, and the interaction with diagnosis and health.