bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Cadence on Time Trial Performance in Recreational Female Cyclists
Authors: Graham Patricia L. , Zoeller Robert F. , Jacobs Patrick L. , Whitehurst Michael A. 
Published: June 2017

Abstract
Graham, PL, Zoeller, RF, Jacobs, PL, and Whitehurst, MA. Effect of cadence on time trial performance in recreational female cyclists. J Strength Cond Res 32(6): 1739–1744, 2018—The impact of pedaling cadence on cycling performance remains unresolved especially in female cyclists. The purpose of this study was to determine the effect of cadence on time trial (TT) performance in recreational female cyclists. Ten recreational female cyclists volunteered to participate in this study. Subjects performed 3 exercise sessions: 1 to assess peak oxygen uptake (V̇o
2peak) and 2 TTs. Cadence was randomly ordered and fixed for each TT (60 or 100 rpm), whereas power output (PO) was freely adjusted by the participant, as tolerated. Time trial time, heart rate (HR), blood lactate, PO, V̇o
2, and ratings of perceived exertion were measured throughout the TTs. The major finding of this study was the significantly faster (p = 0.001) TT time during the 60-rpm condition (34:23 ± 4:21) vs. the 100-rpm condition (37:34 ± 5:53). Also the 60-rpm TT resulted in significant differences for HR (155.9 ± 3.97 vs. 161.2 ± 5.20 b·min−1, p = 0.04), gross efficiency, (21.1 ± 0.37 vs. 17.7 ± 0.85%, p < 0.001), and PO (147 ± 7.06 vs. 129 ± 10.62 W, p = 0.003). Thus, a slower cycling cadence was associated with greater mechanical efficiency and PO, resulting in significantly better performance in a TT. These results suggest that recreational female cyclists may benefit from adopting a low cadence during an 8-km TT.
Determinant Factors of Physical Performance and Specific Throwing in Handball Players of Different Ages
Authors: Ortega-Becerra Manuel , Pareja-Blanco Fernando , Jiménez-Reyes Pedro , Cuadrado-Peñafiel Víctor , González-Badillo Juan J. 
Published: June 2017

Abstract
Ortega-Becerra, M, Pareja-Blanco, F, Jiménez-Reyes, P, Cuadrado-Peñafiel, V, and González-Badillo, JJ. Determinant factors of physical performance and specific throwing in handball players of different ages. J Strength Cond Res 32(6): 1778–1786, 2018—This study aimed to analyze various fitness qualities in handball players of different ages and to determine the relationships between these parameters and throwing velocity. A total of 44 handball players participated, pooled by age groups: professional (ELITE, n = 13); under-18 (U18, n = 16); under-16 (U16, n = 15). The following tests were completed: 20-m running sprints; countermovement jumps (CMJs); jump squat to determine the load that elicited ∼20 cm jump height (JSLOAD-20 cm); a progressive loading test in full squat and bench press to determine the load that elicited ∼1 m·s−1 (SQ-V1-LOAD and BP-V1-LOAD); and handball throwing (jump throw and 3-step throw). ELITE showed greater performance in almost all sprint distances, CMJ, JSLOAD-20 cm, and bench press strength than U18 and U16. The differences between U18 and U16 were unclear for these variables. ELITE also showed greater (p < 0.001) performance for squat strength and throwing than U18 and U16, and U18 attained greater performance (p ≤ 0.05) for these variables than U16. Throwing performance correlated (p ≤ 0.05) with sprint times (r = −0.31; −0.51) and jump ability (CMJ: r = 0.39; 0.56 and JSLOAD-20 cm: r = 0.57; 0.60). Muscle strength was also associated (p < 0.001) with both types of throw (SQ-V1-LOAD: r = 0.66; 0.76; and BP-V1-LOAD: r = 0.33; 0.70). These results indicate that handball throwing velocity is strongly associated with lower-limb strength, although upper-limb strength, jumping and sprint capacities also play a relevant role in throwing performance, suggesting the need for coaches to include proper strength programs to improve handball players' throwing velocity.
The Mouse Lemur, a Genetic Model Organism for Primate Biology, Behavior, and Health
Authors: Ezran Camille , Karanewsky Caitlin J , Pendleton Jozeph L , Sholtz Alex , Biermann Maya R , Willick Jason , Razafindrakoto Andriamahery , Zohdy Sarah , Albertelli Megan A , Krasnow Mark A 
Published: June 2017

AbstractSystematic genetic studies of a handful of diverse organisms over the past 50 years have transformed our understanding of biology. However, many aspects of primate biology, behavior, and disease are absent or poorly modeled in any of the current genetic model organisms including mice. We surveyed the animal kingdom to find other animals with advantages similar to mice that might better exemplify primate biology, and identified mouse lemurs (Microcebus spp.) as the outstanding candidate. Mouse lemurs are prosimian primates, roughly half the genetic distance between mice and humans. They are the smallest, fastest developing, and among the most prolific and abundant primates in the world, distributed throughout the island of Madagascar, many in separate breeding populations due to habitat destruction. Their physiology, behavior, and phylogeny have been studied for decades in laboratory colonies in Europe and in field studies in Malagasy rainforests, and a high quality reference genome sequence has recently been completed. To initiate a classical genetic approach, we developed a deep phenotyping protocol and have screened hundreds of laboratory and wild mouse lemurs for interesting phenotypes and begun mapping the underlying mutations, in collaboration with leading mouse lemur biologists. We also seek to establish a mouse lemur gene “knockout” library by sequencing the genomes of thousands of mouse lemurs to identify null alleles in most genes from the large pool of natural genetic variants. As part of this effort, we have begun a citizen science project in which students across Madagascar explore the remarkable biology around their schools, including longitudinal studies of the local mouse lemurs. We hope this work spawns a new model organism and cultivates a deep genetic understanding of primate biology and health. We also hope it establishes a new and ethical method of genetics that bridges biological, behavioral, medical, and conservation disciplines, while providing an example of how hands-on science education can help transform developing countries.
Bevacizumab for Metastatic Colorectal Cancer: A Global Cost-Effectiveness Analysis
Authors: Goldstein Daniel A. , Chen Qiushi , Ayer Turgay , Chan Kelvin K. W. , Virik Kiran , Hammerman Ariel , Brenner Baruch , Flowers Christopher R. , Hall Peter S. 
Published: June 2017

Abstract

Background
In the U.S., the addition of bevacizumab to first-line chemotherapy in metastatic colorectal cancer (mCRC) has been demonstrated to provide 0.10 quality-adjusted life years (QALYs) at an incremental cost-effectiveness ratio (ICER) of $571,000/QALY. Due to variability in pricing, value for money may be different in other countries. Our objective was to establish the cost-effectiveness of bevacizumab in mCRC in the U.S., U.K., Canada, Australia, and Israel.

Methods
We performed the analysis using a previously established Markov model for mCRC. Input data for efficacy, adverse events, and quality of life were considered to be generalizable and therefore identical for all countries. We used country-specific prices for medications, administration, and other health service costs. All costs were converted from local currency to U.S. dollars at the exchange rates in March 2016. We conducted one-way and probabilistic sensitivity analyses (PSA) to assess the model robustness across parameter uncertainties.

Results
Base case results demonstrated that the highest ICER was in the U.S. ($571,000/QALY) and the lowest was in Australia ($277,000/QALY). In Canada, the U.K., and Israel, ICERs ranged between $351,000 and $358,000 per QALY. PSA demonstrated 0% likelihood of bevacizumab being cost-effective in any country at a willingness to pay threshold of $150,000 per QALY.

Conclusion
The addition of bevacizumab to first-line chemotherapy for mCRC consistently fails to be cost-effective in all five countries. There are large differences in cost-effectiveness between countries. This study provides a framework for analyzing the value of a cancer drug from the perspectives of multiple international payers.
Analysis of the microbial flora in breast abscess: a retrospective cohort study conducted in the emergency department
Authors: Ramakrishnan Ramya , Trichur Ramakrishnan V. , Murugesan Sowmya , Cattamanchi Srihari 
Published: June 2017

Background: Breast abscess develops as a complication of lactational mastitis. Recently, there is an increase in the incidence of non-lactational breast abscess. The aim of the study was to analyse the microbial flora in the lactational and non-lactational breast abscess in the ED and to elucidate the susceptibility of flora to different antibiotics.Methods: This is a retrospective cohort study of breast abscess patients registered in the ED over two years. The case records of these patients were retrieved, and the details of their age, clinical presentation, investigation, and treatment were recorded. Specifically, the pus culture sensitivity and antibiotics used in the management of these patients were noted, and the pattern of microbiological flora analyzed.Results: A total of 124 patients were included in the study, with 97 women were categorized into lactational breast abscess, and 27 women were classified as a non-lactational breast abscess. Mean age was 24 years of age (Range 18 to 56 years). The majority of the women were young between 18 and 34 years of age (83%). The culture was grown in 92% of the patient pus specimens. Staphylococcus aureus (83%) was common organisms cultured in lactational breast abscess. Mixed Flora including Staphylococcus aureus and Group B Streptococci were grown in non-lactational breast abscess.Conclusions: Appropriate antibiotic choices are of immense importance in the management of breast abscess. Mixed flora is common in non - lactational breast abscess when compared with a lactational breast abscess. Staphylococcus Aureus is the most common isolate in both groups.
REDES DE APRENDIZAGEM COLABORATIVAS E INCLUSIVAS
Authors: Rinaldi Renata Portela , Junior Manoel Osmar Seabra 
Published: June 2017

Nos últimos anos o Brasil vem conquistando um lugar de destaque devido às mudanças estruturais que pretendem a efetiva inclusão escolar de Pessoas com Deficiência. Os avanços e conquistas são frutos dos esforços do Ministério da Educação (MEC), dos agentes do sistema educacional, da comunidade acadêmica em geral, os quais têm estabelecido vínculos importantes com a sociedade para esse processo de constituição de um arcabouço político fundamentado na perspectiva da Educação Inclusiva. A Educação a Distância (EaD) e as tecnologias de informação e comunicação (TIC) por sua vez tem possibilitado a experimentação de inovadoras experiências que estimulam e potencializam a articulação de conhecimentos construídos historicamente com a experiência pessoal. Permitem a reflexão sobre as novas formas de comunicação, expressão e cultura na sociedade contemporânea, a abrangência e complexidade da educação, em interface com a tecnologia, as linguagens, formas e conteúdos nos ambientes virtuais.
ENSINO DA MATEMÁTICA COM FERRAMENTAS MEDIADORAS: MOODLE COM GEOGEBRA E WEBQUEST A FAVOR DO APRENDIZADO DE SABERES MATEMÁTICOS
Authors: Reali Graciela Aluizio , Prado Maximiano Rosemeiry De Castro , Delfino de Oliveira Murilo Cretuchi , Bertóli Nilson César 
Published: June 2017

Muito se tem pensado em como tornar o ensino e o aprendizado dos conteúdos e conhecimentos científicos mais significativos, de modo a colaborar com a educação. Nesse sentido, cabe ao professor conhecer aspectos inerentes ao comportamento humano, intermediar e facilitar a interpretação das informações que chegam aos alunos, fazendo com que essas informações se transformem em conhecimento. Portanto, o profissional da educação tem visto seu papel de transmissor de informações passarem para o facilitador da transformação dessas informações em conhecimento, processo que depende tanto do professor quanto do aluno. Destarte, este trabalho apresenta alguns aspectos inerentes ao processo de ensino e aprendizagem da Matemática, destacando o uso das tecnologias da informação e comunicação (TICs) como ferramentas mediadoras e auxiliadoras desse aprendizado. Apresenta também, um ambiente virtual de aprendizagem, o Moodle que engloba o software Geogebra apresentado em uma WebQuest para que juntos possam servir futuramente para o ensino e aprendizado da Matemática na Faculdade de Tecnologia de Ourinhos-Fatec, São Paulo - Brasil. Espera-se, por meio deste trabalho, poder contribuir com discussões e reflexões de algumas questões emblemáticas dessa nova prática e modalidade, bem como difundir e fomentar o uso do aplicativo Geogebra.
Condições higienico sanitarias de feiras livres: uma revisão integrativa
Authors: Da Cruz Matos Johnata , Raice Souza Benvindo Lorena , Oliveira Silva Thayrine , Freitas de Carvalho Luíza Marly 
Published: June 2017

O objetivo do estudo é realizar um levantamento da literatura sobre as condições higiênico-sanitárias de feiras livres no Brasil a partir da análise de artigos publicados em revistas indexadas. Nesse sentido, este estudo é delineado como uma revisão integrativa da literatura, sendo realizada uma busca na Biblioteca Virtual em Saúde (BVS) utilizando os descritores em saúde: Condições sanitárias; Manipulação de alimentos, e Higiene dos alimentos de modo a encontrar 14 artigos que se enquadraram no critério de inclusão do estudo. Após a categorização dos artigos foi possível constatar que na maioria das feiras livres avaliadas, as condições higiênicas de comercialização dos produtos alimentícios são insatisfatórias, constituindo-se um importante vetor no processo de contaminação e proliferação de doenças de origem alimentar. A maior dificuldade encontrada nas feiras é que a há uma necessidade de realizar medidas corretivas a fim de reduzir os riscos nos ambientes em que esses alimentos são comercializados. Descritores: Condições sanitárias; Manipulação de alimentos; Higiene dos alimentos.
Development Of The EGGS Exam Of GeoloGy Standards To Measure Students’ Understanding Of Common Geology Concepts
Authors: Guffey Sarah Katie , Slater Timothy F. , Slater Stephanie J. 
Published: June 2017

Geoscience education researchers have considerable need for criterion-referenced, easy-to-administer, easy-to-score, conceptual surveys for undergraduates taking introductory science survey courses in order for faculty to monitor the learning impacts of innovative teaching. In response, this study establishes the reliability and validity of a 28-item, multiple-choice, pre- and post- EGGS Exam of GeoloGy Standards. EGGS addresses 11 concepts derived from a systematic analysis of the overlapping ideas from national science education reforms: NGSS, AAAS Benchmarks, Earth Science Literacy Principles, and NRC National Science Education Standards. Leveraging best-practices for creating and field-testing items, EGGS emphasizes natural student language over technical scientific vocabulary, leverages illustrations over students’ reading ability, specifically targets students’ misconceptions, and covers the range of topics most geology educators expect general education students to know. EGGS is argued to be valid and reliable with college introductory science survey students based on standard measures, including clinical interviews with students and expert review.
Instrucción pública y demanda por preceptores normalistas en la Araucanía del siglo XIX
Authors: Turra-Díaz Omar , Torres Vásquez Angélica 
Published: June 2017

Este artículo tiene como propósito aportar conocimiento acerca del ejercicio docente en la Araucanía, durante la segunda mitad del siglo XIX, en el contexto de una política estatal que buscó expandir la instrucción pública chilena en el territorio Mapuche. En base a información documental, extraída principalmente de los informes de los Visitadores de escuelas, se presentan datos acerca de la formación y desempeño de los educadores encargados de impartir las primeras letras en el contexto educativo interétnico.
De acuerdo con la información aportada por las fuentes, la falta de preparación en métodos de enseñanza y la carencia de educadores con estudios formales, constituyó un reclamo persistente de Visitadores y autoridades locales, los que a su vez demandaron la presencia de preceptores normalistas. Desde esta perspectiva el estudio presenta antecedentes que permiten comprender la fundación de Escuelas Normales en el territorio de la Araucanía, desde la última década del siglo XIX
Regime tecnológico e ambiente de inovação para o setor de serviços de telecomunicação brasileiro
Authors: Rezende Adriano Alves de , Toyoshima Silvia Harumi 
Published: June 2017

Este artigo analisa o desenvolvimento do setor de serviços de telecomunicação brasileiro à luz da teoria evolucionária neoschumpeteriana. Buscou-se verificar se as características do regime tecnológico brasileiro adequam-se às do cenário internacional, mapear o ambiente de inovação onde os serviços de telecomunicação se inserem e analisar se o Estado, pós-privatização do setor, fomentou a construção de um regime tecnológico e de um ambiente de inovação capazes de promover o desenvolvimento brasileiro. A pesquisa desenvolveu-se mediante análise documental e de dados das Pesquisas de Inovação Tecnológica (2005 e 2008). O regime tecnológico foi estabelecido segundo a taxonomia de Marsili (2001). Concluiu-se que o regime tecnológico dos serviços de telecomunicação brasileiros possui similaridades com o padrão norte-americano e que o setor tende a ser supplier dominated. O ambiente de inovação demonstrou que a estrutura legal-organizacional específica para os serviços de telecomunicação não acompanha o dinamismo inovativo do setor. Já a estrutura que não é específica para sistemas de telecomunicação é que fomenta o ambiente de inovação.
Indústria de Alta Tecnologia: uma tipologia baseada na intensidade de P&D e no desempenho comercial
Authors: Rauen André Tortato , Furtado André Tosi 
Published: June 2017

Este artigo tem por objetivo construir e discutir uma tipologia de indústrias nacionais de alta tecnologia fundamentada na intensidade tecnológica e no desempenho comercial. Para tanto, apoia-se no conceito de fragmentação da produção, contrastando-o com teorias tradicionais de comércio internacional. Para definir a posição das diferentes economias, optou-se por uma análise matricial que cruza indicadores compostos selecionados, resultando numa análise de quadrantes. Essa análise encontrou quadro grupos de países: líderes tecnológicos superavitários; líderes tecnológicos deficitários; seguidores tecnológicos superavitários; e seguidores tecnológicos deficitários. Concluiu-se que as teorias tradicionais de comércio internacional explicam apenas parte desta tipologia e que uma compreensão mais completa, obrigatoriamente, precisa considerar a fragmentação da produção enquanto lógica dominante das cadeias produtivas globais.
Lost-Circulation Control for Formation-Damage Prevention in Naturally Fractured Reservoir: Mathematical Model and Experimental Study
Authors: Xu Chengyuan , Kang Yili , You Lijun , You Zhenjiang 
Published: June 2017

Summary
Drill-in fluid loss is the most important cause of formation damage during the drill-in process in fractured tight reservoirs. The addition of lost-circulation material (LCM) into drill-in fluid is the most popular technique for loss control. However, traditional LCM selection is mainly performed by use of the trial-and-error method because of the lack of mathematical models. The present work aims at filling this gap by developing a new mathematical model to characterize the performance of drill-in fluid-loss control by use of LCM during the drill-in process of fractured tight reservoirs. Plugging-zone strength and fracture-propagation pressure are the two main factors affecting drill-in fluid-loss control. The developed mathematical model consists of two submodels: the plugging-zone-strength model and the fracture-propagation-pressure model. Explicit formulae are obtained for LCM selection dependent on the proposed model to control drill-in fluid loss and prevent formation damage. Effects of LCM mechanical and geometrical properties on loss-control performance are analyzed for optimal fracture plugging and propagation control. Laboratory tests on loss-control effect by use of different types and concentrations of LCMs are performed. Different combinations of acid-soluble rigid particles, fibers, and elastic particles are tested to generate a synergy effect for drill-in fluid-loss control. The derived model is validated by laboratory data and successfully applied to the field case study in Sichuan Basin, China.
Magnetic-Resonance Imaging of Fines Migration in Berea Sandstone
Authors: Afrough Armin , Zamiri Mohammad Sadegh , Romero-Zerón Laura , Balcom Bruce J. 
Published: June 2017

Summary
Fines migration is a phenomenon of practical importance in the petroleum-production and drilling industry. The movement of clay particles, induced by incompatible aqueous-phase chemistry or high flow rate, obstructs pore throats downstream of the fluid flow, leading to permeability reductions that can be as large as two orders of magnitude. Magnetic-resonance-imaging (MRI) methods derived from the Carr-Purcell-Meiboom-Gill (CPMG) method (Meiboom and Gill 1958) can map T2 distributions in porous rocks, hence showing the spatial variation of the pseudo-pore-size distribution.
In this work, the traditional water-shock experiment was used to mobilize clay particles in the aqueous phase flowing in Berea core plugs. Spin-echo single-point imaging (SE-SPI), a phase-encoding MRI method derived from the CPMG method, was used to determine spatially resolved T2 spectra of the samples, and therefore the pseudo-pore-size distributions.
The shift in the T2 spectra of the core inlet and outlet showed opposite trends. The pore-size distribution of the inlet and outlet, inferred from T2 distributions, were shifted to larger and smaller values, respectively. Therefore, the average pore size was increased at the inlet of the core and reduced at the outlet of the core. This MRI method provides a new analytical approach to screen reservoirs for potential fines-migration problems.