bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asupan Protein dan Kalium Berhubungan dengan Penurunan Tekanan Darah Pasien Hipertensi Rawat Jalan (Protein and Potassium Intake Related to Decreased Blood Pressure in Outclinic Hypertensive Patients)
Authors: Kusumastuty Inggita , Widyani Desty , Wahyuni Endang Sri 
Published: August 2016

AbstrakHipertensi merupakan salah satu penyakit degeneratif yang prevalensinya semakin meningkat setiap tahun. Salah satu faktor yang mempengaruhi tekanan darah pada pasien hipertensi adalah asupan protein dan kalium. Tujuan penelitian ini untuk mengetahui hubungan asupan protein dan asupan kalium terhadap tekanan darah pasien hipertensi rawat jalan di Puskesmas Bareng Kota Malang. Metode penelitian yang digunakan dalam penelitian ini adalah cross sectional. Sampel dipilih dengan cara purposive sampling sebanyak 60 orang pasien hipertensi yang ada diwilayah kerja Puskesmas Bareng dan sudah memenuhi kriteria inklusi. Uji statistik yang digunakan adalah uji korelasi Spearman dengan variabel yang diukur yaitu asupan protein, asupan kalium, tekanan darah sistolik, dan tekanan darah diastolik. Hasil analisis bivariat menunjukkan ada hubungan yang signifikan antara asupan protein dengan tekanan darah sistolik (rs= -0,407, p=0,001) dan tekanan darah diastolik (rs = -0,519, p=0,000) dengan arah korelasi negatif. Asupan kalium berhubungan dengan tekanan darah sistolik (rs= -0,518, p=0,000) dan tekanan darah diastolik (rs= -0,419, p=0,000) dengan arah korelasi negatif. Kesimpulan dari penelitian ini adalah asupan protein dan asupan kalium berhubungan signifikan dengan penurunan tekanan darah pada pasien hipertensi.Kata kunci: protein, kalium, tekanan darah, hipertensi.Â AbstractHypertension is one of the degenerative diseases whose prevalence experiences an increase every year. One of the factors that influence blood pressure in hypertensive patients is protein and potassium intake. The purpose of this study was to determine the relationship of protein intake and potassium intake on blood pressure in hypertensive outpatient in community health centers of Bareng Malang. The method of this study was cross â€“ sectional study. Samples were selected by purposive sampling with 60 hypertensive patients who have already met the inclusion criteria. Statistical test used Spearman correlation test with a variable that measured protein intake, potassium intake, systolic and diastolic blood pressure. Bivariate testÂ indicates that a protein intake was related significantly associated to systolic blood pressure (rs = -0,407, p = 0,001) and diastolic blood pressure (rs = -0,519, p = 0,000) leading to negative correlation. Potassium intake had a significant correlation to systolic blood pressure (rs = -0518, p=0,000) and diastolic blood pressure (rs= -0419, p=0.000) leading to negative correlation. It was then concluded from thisresearch that protein and potassium intake was associated with systolic and diastolic blood pressure.Keywords: protein, potassium, blood pressure, hypertension.
The Health Benefits of Children by Different Natural Landscape Contacting Level
Authors: Tseng Tzuhui Angie , Shen Ching-Cheng 
Published: August 2016

Previous studies seldom explore the health benefits of different levels of nature exposure on children. 241 valid samples from five primary schools in Hsinchu, Taiwan were investigated. Results showed that comparing to being on school campuses, children would have higher levels of physical activity when visiting neighborhood parks and forest. Only the forest level natural landscape experiences have significant positive impact on enjoying nature, preferences and empathy and sense of belonging. Forest level natural landscape experiences would also positively affect mental health, and physical health is built up through physical activity. Therefore, rural natural settings would be more beneficial to children. © 2016. The Authors. Published for AMER ABRA by e-International Publishing House, Ltd., UK. Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies, Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.Keywords: Natural experience, The Connection to Nature Index (CNI) for children; Children's Physical Activity Scale (PAQ-C); Pediatric quality of life questionnaire (PedsQL ™)
Association of a Biomarker of Glucose Peaks, 1,5-Anhydroglucitol, With Subclinical Cardiovascular Disease
Authors: Liang Menglu , McEvoy John William , Chen Yuan , Sharrett A. Richey , Selvin Elizabeth 
Published: August 2016

OBJECTIVE
1,5-Anhydroglucitol (1,5-AG) is a biomarker of glucose peaks and has been associated with clinical cardiovascular disease. However, the association between 1,5-AG and subclinical cardiovascular disease is unknown. We investigated the association of 1,5-AG with subclinical myocardial damage (assessed by high-sensitivity cardiac troponin T [hs-cTnT]) and atherosclerosis (assessed by carotid intima-media thickness [CIMT] and carotid plaque).

RESEARCH DESIGN AND METHODS
We measured 1,5-AG, hs-cTnT, CIMT, and carotid plaque among 10,072 people without diabetes and 681 with diabetes who attended the second examination of the Atherosclerosis Risk in Communities (ARIC) Study (baseline, 1990–1992). We used Poisson regression to characterize the associations between 1,5-AG and prevalent elevated hs-cTnT, thick CIMT, or carotid plaque. Among 9,145 people with a second hs-cTnT measurement 6 years later, we used multinomial logistic regression to assess associations with incident elevation in hs-cTnT.

RESULTS
We found that in people with diabetes, lower 1,5-AG (&lt;6 μg/mL) was cross-sectionally associated with elevated hs-cTnT (prevalence ratio 2.06, 95% CI 1.23–3.46) compared with higher 1,5-AG (≥10 μg/mL). Associations in people without diabetes and with thick CIMT or the presence of carotid plaque were less robust. Low 1,5-AG was prospectively associated with the 6-year incident elevation in hs-cTnT (relative risk 2.90, 95% CI 1.23–6.85) in people with diabetes. All associations were strongly attenuated with further adjustment for HbA1c.

CONCLUSIONS
In people with diabetes, 1,5-AG was associated with subclinical cardiovascular disease, particularly chronic subclinical myocardial damage. Nonetheless, whether observed associations are truly independent of average glycemia is unclear.
The Responsiveness of the Modified Childhood Health Assessment Questionnaire
Authors: Peters Shannon , Ota Sylvia , Bolous Emily , Reich Erin , Chait Samantha , Feldman Brian M. 
Published: August 2016

Objective.To determine the ability of the revised version of the Childhood Health Assessment Questionnaire (CHAQ), the VASCHAQ, to detect clinical change over time in pediatric patients with juvenile idiopathic arthritis (JIA). We studied the relative responsiveness of the VASCHAQ as compared to the original CHAQ-30 and revised CHAQ-38, as well as the parent-patient, physician-patient, and physician-parent concordance.Methods.The CHAQ-38 and VASCHAQ were administered to 30 parents and patients (if older than 8 years) with any subtype of JIA before and after the start of a new treatment. The standardized response means (SRM) were calculated for the VASCHAQ, the original CHAQ-30, and the CHAQ-38. Comparisons of SRM were made using the relative SRM. Parent-patient, physician-patient, and physician-parent concordances were assessed by calculating a series of intraclass correlation coefficients.Results.Twenty-seven parents and 21 patients completed questionnaires at both visits. All questionnaires demonstrated large responsiveness; however, the VASCHAQ was found to be about 25% more responsive than both the original CHAQ-30 and CHAQ-38.Conclusion.The VASCHAQ was moderately more responsive than the CHAQ-30 and CHAQ-38 in both parent and patient groups and should be considered for use in studies evaluating change in function over time.
Transduction of Functionally Contrasting Signals by Two Mycobacterial PPE Proteins Downstream of TLR2 Receptors
Authors: Udgata Atul , Qureshi Rahila , Mukhopadhyay Sangita 
Published: August 2016

Abstract
As pathogen-associated molecular pattern sensors, the TLRs can detect diverse ligands to elicit either proinflammatory or anti-inflammatory responses, but the mechanism that dictates such contrasting immune responses is not well understood. In this work, we demonstrate that proline–proline–glutamic acid (PPE)17 protein of Mycobacterium tuberculosis induces TLR1/2 heterodimerization to elicit proinflammatory-type response, whereas PPE18-induced homodimerization of TLR2 triggers anti-inflammatory type responses. Ligation of TLR1/2 caused an increased recruitment of IL-1R–associated kinase (IRAK)1, MyD88, and protein kinase C (PKC)ε to the downstream TLR-signaling complex that translocated PKCε into the nucleus in an IRAK1-dependent manner. PKCε-mediated phosphorylation allowed the nuclear IRAK3 to be exported to the cytoplasm, leading to increased activation of ERK1/2, stabilization of MAPK phosphatase 1 (MKP-1), and induction of TNF-α with concomitant downregulation of p38MAPK. Silencing of TLR1 inhibited PPE17-triggered cytoplasmic export of IRAK3 as well as TNF-α induction, suggesting an important role of TLR1/2 heterodimer in regulating proinflammatory responses via the IRAK3-signaling pathway. In contrast, PPE18-mediated homodimerization of TLR2 caused poorer cytoplasmic export of nuclear IRAK3 and MKP-1 stabilization, resulting in increased p38MAPK activation. Our study hints to a novel mechanism that implicates PKCε–IRAK3–MKP-1 signaling in the regulation of MAPK activity and inflammatory cascades downstream of TLR2 in tuberculosis.
Heparan Sulfate Proteoglycans Promote Telomerase Internalization and MHC Class II Presentation on Dendritic Cells
Authors: Galaine Jeanne , Kellermann Guillaume , Guillaume Yves , Boidot Romain , Picard Emilie , Loyon Romain , Queiroz Lise , Boullerot Laura , Beziaud Laurent , Jary Marine , Mansi Laura , André Claire , Lethier Lydie , Ségal-Bendirdjian Evelyne , Borg Christophe , Godet Yann , Adotévi Olivier 
Published: August 2016

Abstract
Telomerase is a prototype-shared tumor Ag and represents an attractive target for anticancer immunotherapy. We have previously described promiscuous and immunogenic HLA-DR–restricted peptides derived from human telomerase reverse transcriptase (hTERT) and referred as universal cancer peptide (UCP). In nonsmall cell lung cancer, the presence of spontaneous UCP-specific CD4 T cell responses increases the survival of chemotherapy-responding patients. However, the precise mechanisms of hTERT’s uptake, processing, and presentation on MHC-II molecules to stimulate CD4 T cells are poorly understood. In this work, by using well-characterized UCP-specific CD4 T cell clones, we showed that hTERT processing and presentation on MHC-II involve both classical endolysosomal and nonclassical cytosolic pathways. Furthermore, to our knowledge, we demonstrated for the first time that hTERT’s internalization by dendritic cells requires its interaction with surface heparan sulfate proteoglycans. Altogether, our findings provide a novel mechanism of tumor-specific CD4 T cell activation and will be useful for the development of novel cancer immunotherapies that harness CD4 T cells.
β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage
Authors: Boucard-Jourdin Mathilde , Kugler David , Endale Ahanda Marie-Laure , This Sébastien , De Calisto Jaime , Zhang Ailiang , Mora J. Rodrigo , Stuart Lynda M. , Savill John , Lacy-Hulbert Adam , Paidassi Helena 
Published: August 2016

Abstract
Activation of TGF-β by dendritic cells (DCs) expressing αvβ8 integrin is essential for the generation of intestinal regulatory T cells (Tregs) that in turn promote tolerance to intestinal Ags. We have recently shown that αvβ8 integrin is preferentially expressed by CD103+ DCs and confers their ability to activate TGF-β and generate Tregs. However, how these DCs become specialized for this vital function is unknown. In this study, we show that β8 expression is controlled by a combination of factors that include DC lineage and signals derived from the tissue microenvironment and microbiota. Specifically, our data demonstrate that TGF-β itself, along with retinoic acid and TLR signaling, drives expression of αvβ8 in DCs. However, these signals only result in high levels of β8 expression in cells of the cDC1 lineage, CD8α+, or CD103+CD11b− DCs, and this is associated with epigenetic changes in the Itgb8 locus. Together, these data provide a key illustrative example of how microenvironmental factors and cell lineage drive the generation of regulatory αvβ8-expressing DCs specialized for activation of TGF-β to facilitate Treg generation.
Evolution of the breeding range of the “italian” Wagtail Motacilla flava cinereocapilla
Authors: Ferlini Flavio 
Published: August 2016

<p>[The paper shows the evolution of the breeding distribution of the Ashy-headed Wagtail <em>Motacilla</em> <em>flava</em> <em>cinereocapilla</em> in the period 1820-2014. Until 1880, the subspecies nested along the coast north and east of the Adriatic Sea, with some settlements (probably of poor numerical consistency) located in suitable areas of Tuscany, Sicily and Provence; after 1880 it was observed to appear regularly in the Po Valley during migration, and afterwards to occupy the area widely as a breeder. During the nineteenth century the Po Valley underwent major transformation processes with the consequent disruption of ancient agricultural rotations, and an increase of 1°C in the average temperature was also recorded in the area. Out of all the changes that occurred, besides the abundant availability of water, the biotic factor that probably favored the expansion of the subspecies in the Po valley the most is the increase in livestock and the consequent increase in the meadowlands: the first mowing of grass coincides temporally with the hatching of yellow wagtails (often nesting in neighboring fields of wheat), offering them the opportunity to increase the efficiency and effectiveness of foraging on the open ground, with likely benefits for the reproductive success. In the first half of the twentieth century the Ashy-headed Wagtail completed the occupation of the Po Valley, and in the late 1940 a new phase began, during which it settled in new areas in central and southern Italy and Sardinia, extending its distribution area in southern France; but, above all, appearing with increasing frequency and regularity during migrations north of the Alps. These northward shifts later materialized in the settlement of several reproductive groups in France, Switzerland, Germany and Austria, always along basins of rivers or near lakes. Water seems to be the catalyst for the presence of the subspecies. This further expansion phase has probably been favored by climate changes, and in particular by the rise in temperature in the Greater Alpine Region. Favoured by this situation, the subspecies has also colonized mountain areas: in France up to 350 m.a.s.l. in the department of Isère, in Switzerland up to 1700-1800 m.a.s.l. in the Upper Engadine, in Germany up to 880 m.a.s.l. at Ammer and Grunt lakes, in Austria up to 960 m.a.s.l. in Hochfilzen and in Bosnia-Herzegovina up to 720 m.a.s.l. in the plain of Livanjsko. In the Italian Alps it reached the altitude of about 900 m.a.s.l. in Venosta Valley and up to 1000 m.a.s.l. in central Apennines. Since the last decades of the twentieth century nestings have been recorded in Spain. Instead, the breeding of the subspecies in Maghreb is still uncertain.]</p><p> </p>
The Indian scenario of head and neck oncology – Challenging the dogmas
Authors: Tuljapurkar Vidisha , Dhar Harsh , Mishra Aseem , Chakraborti Swagnik , Chaturvedi Pankaj , Pai Prathamesh S. 
Published: August 2016

AbstractHead and neck cancers (HNCs) are the most common malignancies worldwide. Asian populations bear major burden of this disease, with certain unique characteristics. Although significant research in HNCs is ongoing globally, many clinical issues still remain unanswered. We performed a literature search to find noteworthy Indian studies that changed practice of HNC as well as to look for areas for further research in this field. Many randomized controlled trials as well as large patient series are reported in the field of radiotherapy, chemotherapy, and surgical management of HNC. Still, many areas such as palliative therapy, targeted agents, and newer chemotherapeutic agents remain unexplored. Planned collaborative research is need of the hour to provide more evidenced based.
Gastrointestinal cancers in India: Treatment perspective
Authors: Ghadyalpatil Nikhil Suresh , Supriya Chopra , Prachi Patil , Ashwin Dsouza , Avanish Saklani 
Published: August 2016

AbstractGI cancer is not one cancer but is a term for the group of cancers that affect the digestive system including gastric cancer (GC), colorectal cancer (CRC), hepatocellular carcinoma (HCC), esophageal cancer (EC), and pancreatic cancer (PC). Overall, the GI cancers are responsible for more cancers and more deaths from cancer than any other organ. 5 year survival of these cancers remains low compared to western world. Unlike the rest of the world where organ based specialities hepatobiliary, pancreatic, colorectal and esophagogastric exist , these cancers are managed in India by either a gastrointestinal surgeons, surgical oncologist, or a general surgeon with varying outcomes.The aim of this review was to collate data on GI cancers in indian continent. In colorectal cancers, data from tertiary care centres identifies the unique problem of mucinous and signet colorectal cancer. Results of rectal cancer resection in terms of technique (intersphincteric resection, extralevator aper, minimal invasive approach ) to be comparable with world literature. However long term outcome and data regarding colon cancers and nationally is needed. Gastric cancer at presentation are advanced and in surgically resected patients, there is need for a trial to compare chemoradiation vs chemotherapy alone to prevent loco regional recurrence. Data on minimal invasive gastric cancer surgery may be sparse for the same reason. Theree is a lot of data on surgical techniques and perioperatve outcomes in pancreatic cancer. There is a high volume of locally advanced gallbladder cancers with efforts on to decide whether neoadjuvant chemotherapy or neoadjuvant chemoradiotherapy is better for down staging. Considering GI cancers, a heterogeneous disease with site specific treatment options and variable outcomes, the overall data and outcomes are extremely variable. Young patients with pathology unique to the Indian subcontinent (for example, signet ring rectal cancer, GBCs) need focussed attention. Solution for such pathology needs to come from the Indian continent itself. Joint efforts to improve outcomes for GI cancer can be integrated under the national cancer grid program.
Summary of the published Indian data on chronic myeloid leukemia
Authors: Singhal Manish K. , Sengar Manju , Nair Reena 
Published: August 2016

AbstractChronic myelogenous leukemia (LML) was recognized as a distinct entity in the mid-1800s. Since Nowell and Hunagerford initiated their research on CML in1960 our understanding in CML has been increasing. Imatinib became the preferred treatment from 2000 onwards as a result of its unprecedented success. The lack of structured Indian data on CML led to the formation of a CML data cansortuim which invited CML data albiet retro spartive form around the country including major cancer service providers both government and private. We provide a summary of published Indian data on CML here.
Cytokines and Prognostic Factors in Epithelial Ovarian Cancer
Authors: Jammal Millena Prata , Martins-Filho Agrimaldo , Silveira Thales Parenti , Murta Eddie Fernando Candido , Nomelini Rosekeila Simões 
Published: August 2016

Introduction Ovarian cancer has a high mortality and delayed diagnosis. Inflammation is a risk factor for ovarian cancer, and the inflammatory response is involved in almost all stages of tumor development. Immunohistochemical staining in stroma and epithelium of a panel of cytokines in benign and malignant ovarian neoplasm was evaluated. In addition, immunostaining was related to prognostic factors in malignant tumors. Method The study group comprised 28 ovarian benign neoplasias and 28 ovarian malignant neoplasms. A panel of cytokines was evaluated by immunohistochemistry (Th1: IL-2 and IL-8; Th2: IL-5, IL-6, and IL-10; and TNFR1). Chi-square test with Yates’ correction was used, which was considered significant if less than 0.05. Results TNFR1, IL-5, and IL-10 had more frequent immunostaining 2/3 in benign neoplasms compared with malignant tumors. Malignant tumors had more frequent immunostaining 2/3 for IL-2 in relation to benign tumors. The immunostaining 0/1 of IL 8 was more frequent in the stroma of benign neoplasms compared with malignant neoplasms. Evaluation of the ovarian cancer stroma showed that histological grade 3 was significantly correlated with staining 2/3 for IL-2 ( P = 0.004). Women whose disease-free survival was less than 2.5 years had TNFR1 stromal staining 2/3 ( P = 0.03) more frequently. Conclusion IL-2 and TNFR1 stromal immunostaining are related prognostic factors in ovarian cancer and can be the target of new therapeutic strategies.
Methylammonium uptake by Chesapeake Bay phytoplankton: Evaluation of the use of the ammonium analogue for field uptake measurements1
Authors: Wheeler Patricia A. , McCarthy James J. 
Published: August 2016

The uptake of methylammonium (MA) by Chesapeake Bay phytoplankton was measured in short term experiments by using the 14C radioisotope. This uptake was inversely related to ambient NH4+ concentrations, and the specificity for uptake of both substrates was demonstrated by competitive inhibition. At stations with low ambient NH4+, MA uptake followed saturation kinetics, but the Vmax values decreased over time during 10–60‐min incubations. Uptake rates of MA were generally lower than those of NH4+, but in short incubations (10–15 min) the Vmax values were similar.Although MA and NH4+ are taken up by the same transport system, the utility of MA as an NH4+ analogue is restricted by the strong inhibition of MA uptake by low concentrations of NH4+ and by the fact that in some cases MA uptake primarily reflects membrane transport, whereas NH4+ uptake can also reflect metabolic assimilation. Our results show that in typical uptake experiments, NH4+ uptake is rate‐limited by either internal pool filling or metabolic assimilation rather than by the membrane transport system. As a consequence, the kinetic parameters reported in the literature for NH4+ uptake overestimate Ks and underestimate Vmax for the membrane transport system.