bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion
Authors: Sciortino Marianna , Camacho-Leal Maria del Pilar , Orso Francesca , Grassi Elena , Costamagna Andrea , Provero Paolo , Tam Wayne , Turco Emilia , Defilippi Paola , Taverna Daniela , Cabodi Sara 
Published: April 2017

AbstractErbB2 overexpression is detected in approximately 20% of breast cancers and is correlated with poor survival. It was previously shown that the adaptor protein p130Cas/BCAR1 is a crucial mediator of ErbB2 transformation and that its overexpression confers invasive properties to ErbB2-positive human mammary epithelial cells. We herein prove, for the first time, that the transcriptional repressor Blimp1 is a novel mediator of p130Cas/ErbB2-mediated invasiveness. Indeed, high Blimp1 expression levels are detected in invasive p130Cas/ErbB2 cells and correlate with metastatic status in human breast cancer patients. The present study, by using 2D and 3D breast cancer models, shows that the increased Blimp1 expression depends on both MAPK activation and miR-23b downmodulation. Moreover, we demonstrate that Blimp1 triggers cell invasion and metastasis formation via its effects on focal adhesion and survival signaling. These findings unravel the previously unidentified role that transcriptional repressor Blimp1 plays in the control of breast cancer invasiveness.
Assessment of metabolic phenotypic variability in children’s urine using 1H NMR spectroscopy
Authors: Maitre Léa , Lau Chung-Ho E. , Vizcaino Esther , Robinson Oliver , Casas Maribel , Siskos Alexandros P. , Want Elizabeth J. , Athersuch Toby , Slama Remy , Vrijheid Martine , Keun Hector C. , Coen Muireann 
Published: April 2017

AbstractThe application of metabolic phenotyping in clinical and epidemiological studies is limited by a poor understanding of inter-individual, intra-individual and temporal variability in metabolic phenotypes. Using 1H NMR spectroscopy we characterised short-term variability in urinary metabolites measured from 20 children aged 8–9 years old. Daily spot morning, night-time and pooled (50:50 morning and night-time) urine samples across six days (18 samples per child) were analysed, and 44 metabolites quantified. Intraclass correlation coefficients (ICC) and mixed effect models were applied to assess the reproducibility and biological variance of metabolic phenotypes. Excellent analytical reproducibility and precision was demonstrated for the 1H NMR spectroscopic platform (median CV 7.2%). Pooled samples captured the best inter-individual variability with an ICC of 0.40 (median). Trimethylamine, N-acetyl neuraminic acid, 3-hydroxyisobutyrate, 3-hydroxybutyrate/3-aminoisobutyrate, tyrosine, valine and 3-hydroxyisovalerate exhibited the highest stability with over 50% of variance specific to the child. The pooled sample was shown to capture the most inter-individual variance in the metabolic phenotype, which is of importance for molecular epidemiology study design. A substantial proportion of the variation in the urinary metabolome of children is specific to the individual, underlining the potential of such data to inform clinical and exposome studies conducted early in life.
Carbon nanotube/metal-sulfide composite flexible electrodes for high-performance quantum dot-sensitized solar cells and supercapacitors
Authors: Muralee Gopi Chandu V. V. , Ravi Seenu , Rao S. Srinivasa , Eswar Reddy Araveeti , Kim Hee-Je 
Published: April 2017

AbstractCarbon nanotubes (CNT) and metal sulfides have attracted considerable attention owing to their outstanding properties and multiple application areas, such as electrochemical energy conversion and energy storage. Here we describes a cost-effective and facile solution approach to the preparation of metal sulfides (PbS, CuS, CoS, and NiS) grown directly on CNTs, such as CNT/PbS, CNT/CuS, CNT/CoS, and CNT/NiS flexible electrodes for quantum dot-sensitized solar cells (QDSSCs) and supercapacitors (SCs). X-ray photoelectron spectroscopy, X-ray diffraction, and transmission electron microscopy confirmed that the CNT network was covered with high-purity metal sulfide compounds. QDSSCs equipped with the CNT/NiS counter electrode (CE) showed an impressive energy conversion efficiency (η) of 6.41% and remarkable stability. Interestingly, the assembled symmetric CNT/NiS-based polysulfide SC device exhibited a maximal energy density of 35.39 W h kg−1 and superior cycling durability with 98.39% retention after 1,000 cycles compared to the other CNT/metal-sulfides. The elevated performance of the composites was attributed mainly to the good conductivity, high surface area with mesoporous structures and stability of the CNTs and the high electrocatalytic activity of the metal sulfides. Overall, the designed composite CNT/metal-sulfide electrodes offer an important guideline for the development of next level energy conversion and energy storage devices.
Identification and characterization of miRNAs in two closely related C4 and C3 species of Cleome by high-throughput sequencing
Authors: Gao Shuangcheng , Zhao Wei , Li Xiang , You Qingbo , Shen Xinjie , Guo Wei , Wang Shihua , Shi Guoan , Liu Zheng , Jiao Yongqing 
Published: April 2017

AbstractCleome gynandra and Cleome hassleriana, which are C4 and C3 plants, respectively, are two species of Cleome. The close genetic relationship between C. gynandra and C. hassleriana provides advantages for discovering the differences in leaf development and physiological processes between C3 and C4 plants. MicroRNAs (miRNAs) are a class of important regulators of various biological processes. In this study, we investigate the differences in the characteristics of miRNAs between C. gynandra and C. hassleriana using high-throughput sequencing technology. In total, 94 and 102 known miRNAs were identified in C. gynandra and C. hassleriana, respectively, of which 3 were specific for C. gynandra and 10 were specific for C. hassleriana. Ninety-one common miRNAs were identified in both species. In addition, 4 novel miRNAs were detected, including three in C. gynandra and three in C. hassleriana. Of these miRNAs, 67 were significantly differentially expressed between these two species and were involved in extensive biological processes, such as glycol-metabolism and photosynthesis. Our study not only provided resources for C. gynandra and C. hassleriana research but also provided useful clues for the understanding of the roles of miRNAs in the alterations of biological processes in leaf tissues during the evolution of the C4 pathway.
Does Body Mass Index Interfere in the Formation of Speech Formants?
Authors: Takaki Patricia , Vieira Marilena , Said Angelica , Bommarito Silvana 
Published: April 2017

Introduction Studies in the fields of voice and speech have increasingly focused on the vocal tract and the importance of its structural integrity, and changes in the anatomy and configuration of the vocal tract determine the variations in phonatory and acoustic measurements, especially in the formation of the formants (Fs). Recent studies have revealed the functional consequences arising from being overweight and having an accumulation of fat in the pharyngeal region, including obstructive sleep apnea syndrome (OSAS) and impacts on the voice.
Objectives To assess the relationship between body mass index (BMI) and analysis of the speech.
Methods This study was approved by the Ethics Committee of the Universidade Federal de São Paulo (no. 288,430). The cohort consisted of 124 individuals aged between 18 and 45 with full permanent dentition and selected randomly. The participants underwent a brief medical history taking, BMI assessments and recording emissions of the sustained vowels /a/, /ε/, /i/, and /u/ by acoustic program PRAAT (v. 5.3.85, Boersma and Weenink, Amsterdam, Netherlands). Recordings were taken using a unidirectional microphone headset (model Karsect HT-9, Guangdong, China), with a condenser connected to an external sound card (USB-SA 2.0, model Andrea, PureAudio™, Pleasant Grove, UT, USA), to reduce noise.
Results There was a significant correlation between BMI and formant 3 (F3) vowel /a/; however, there was a low degree of correlation intensity.
Conclusions We did not observe a correlation between the BMI and the speech formants, but we believe there is a trend in this correlation that leads to changes in speech patterns with increases in BMI.
Explicit solutions and multiplicity results for some equations with the 𝑝-Laplacian
Authors: Korman Philip 
Published: April 2017

We derive explicit ground state solutions for several equations with the

p
p

-Laplacian in

R
n

R^n

, including (here

φ
(
z
)
=
z

|

z

|

p
−
2

\varphi (z)=z|z|^{p-2}

, with

p
>
1

p>1

)
\[

φ

(

u
′

(
r
)
)

′

+

n
−
1

r

φ

(

u
′

(
r
)
)

+

u
M

+

u
Q

=
0

.

\varphi \left (u’(r)\right )’ +\frac {n-1}{r} \varphi \left (u’(r)\right )+u^M+u^Q=0 \,.

\]
The constant

M
>
0

M>0

is assumed to be below the critical power, while

Q
=

M
p
−
p
+
1

p
−
1

Q=\frac {M p-p+1}{p-1}

is above the critical power. This explicit solution is used to give a multiplicity result, similarly to C. S. Lin and W.-M. Ni (1998). We also give the

p
p

-Laplace version of G. Bratu’s solution, connected to combustion theory.

In another direction, we present a change of variables which removes the non-autonomous term

r

α

r^{\alpha }

in
\[

φ

(

u
′

(
r
)
)

′

+

n
−
1

r

φ

(

u
′

(
r
)
)

+

r

α

f
(
u
)
=
0

,

\varphi \left (u’(r)\right )’ +\frac {n-1}{r} \varphi \left (u’(r)\right )+r^{\alpha } f(u)=0 \,,

\]
while preserving the form of this equation. In particular, we study singular equations, when

α
>
0

\alpha >0

, that occur often in applications. The Coulomb case

α
=
−
1

\alpha =-1

turned out to give the critical power.
Seascapes are landscapes after all; Comment on Manderson (2016): Seascapes are not landscapes: an analysis performed using Bernhard Riemann's rules. ICES Journal of Marine Science, 73:1831–1838
Authors: Bell Susan S. , Furman Bradley T. 
Published: April 2017

Abstract
Recently, Manderson (2016, Seascapes are not landscapes: an analysis performed using Bernhard Riemann's rules: ICES Journal of Marine Science, 73: 1831-1838) argued that landscape ecology approaches developed in terrestrial habitats have little practical application for the study of marine “seascapes”. Here, we offer a contrasting perspective to this over-generalization. We first focus on historical uses of the term “seascape” to delineate the wide range of habitats that have been designated as such. After providing a brief overview of the study of seascape ecology, we argue that concepts and methodology originating from terrestrial disciplines have, in fact, provided an important cornerstone for investigating the dynamics of nearshore marine ecosystems. We present examples of coastal seascape research that have successfully applied terrestrial landscape theory and revisit points raised by Manderson regarding the application of landscape approaches to the marine environment. Overall, we contend that Manderson’s thesis may apply to some, but not most, use of landscape constructs for investigating aquatic environments. Moreover, we suggest that the study of coastal landscapes will continue to yield valuable insight into the spatiotemporal workings of aquatic ecosystems, and that this particular avenue of ecological investigation will only increase in its relevance as human impacts intensify.
Finding forming globular clusters at high redshifts
Authors: Renzini Alvio 
Published: April 2017

Abstract
The formation of globular clusters (GCs) with their multiple stellar populations remains a puzzling, unsolved problem in astrophysics. One way to gather critical insight consists in finding sizable numbers of GC progenitors (GCPs) while still near the peak of their star formation phase, at a look-back time corresponding to GC ages (∼12.5 Gyr, or z ≃ 5). This opportunity is quantitatively explored, calculating how many GCPs could be detected by deep imaging in the optical, near-IR and mid-IR bands. For concreteness, for the imaging camera performances those of NIRCam on board of James Webb Space Telescope are adopted. The number of GCPs that could be detected scales linearly with their mass, i.e. on how much more massive GCPs were compared to their GC progeny, and perspectives look promising. Besides providing direct evidence on GC formation, the detection of GCPs, their clustering, with or without a central galaxy already in place, would shed light on the relative timing of GC formation and galaxy growth and assembly. All this may be the result of dedicated observations as well as a side benefit of deep imaging meant to search for the agents of cosmic reionization.
Microsurgical Clipping of an Anterior Communicating Artery Aneurysm Using a Novel Robotic Visualization Tool in Lieu of the Binocular Operating Microscope: Operative Video
Authors: Klinger Daniel R , Reinard Kevin A , Ajayi Olaide O , Delashaw Johnny B 
Published: April 2017

Abstract

INTRODUCTION
The binocular operating microscope has been the visualization instrument of choice for microsurgical clipping of intracranial aneurysms for many decades.

OBJECTIVE
To discuss recent technological advances that have provided novel visualization tools, which may prove to be superior to the binocular operating microscope in many regards.

METHODS
We present an operative video and our operative experience with the BrightMatterTM Servo System (Synaptive Medical, Toronto, Ontario, Canada) during the microsurgical clipping of an anterior communicating artery aneurysm. To the best of our knowledge, the use of this device for the microsurgical clipping of an intracranial aneurysm has never been described in the literature.

RESULTS
The BrightMatterTM Servo System (Synaptive Medical) is a surgical exoscope which avoids many of the ergonomic constraints of the binocular operating microscope, but is associated with a steep learning curve. The BrightMatterTM Servo System (Synaptive Medical) is a maneuverable surgical exoscope that is positioned with a directional aiming device and a surgeon-controlled foot pedal. While utilizing this device comes with a steep learning curve typical of any new technology, the BrightMatterTM Servo System (Synaptive Medical) has several advantages over the conventional surgical microscope, which include a relatively unobstructed surgical field, provision of high-definition images, and visualization of difficult angles/trajectories.

CONCLUSION
This device can easily be utilized as a visualization tool for a variety of cranial and spinal procedures in lieu of the binocular operating microscope. We anticipate that this technology will soon become an integral part of the neurosurgeon's armamentarium.
The Association Between Posttraumatic Stress Disorder and Perceptions of Deployment-Related Injury in Veterans With and Without Mild Traumatic Brain Injury
Authors: Bahraini Nazanin H. , Monteith Lindsey L. , Gerber Holly R. , Forster Jeri E. , Hostetter Trisha A. , Brenner Lisa A. 
Published: April 2017

Objectives:
To examine whether the association between posttraumatic stress disorder (PTSD) and injury perceptions (ie, consequences, emotional representations, and coherence) differs for Veterans with mild traumatic brain injury (mTBI) compared with Veterans with non-TBI (ie, orthopedic).

Participants:
Eighty Veterans injured during post-9/11 deployments.

Design:
Observational, 2×2 factorial design.

Main Measures:
Injury histories ascertained using the Ohio State University TBI-Identification Method and Deployment Injury Questionnaire; Injury Perception Questionnaire-Revised (injury perceptions); Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (PTSD diagnosis); and PTSD Symptom Checklist-Civilian Version (PTSD symptoms).

Results:
The association between PTSD diagnosis and injury perceptions did not differ between Veterans with mTBI and those with non-TBIs, adjusting for age, subjective pain, and depressive symptoms. PTSD symptom severity was significantly associated with injury consequences (P < .0001) and emotional representations (P < .0001), irrespective of injury type (mTBI vs non-TBI). Only injury coherence was associated with a significant interaction between PTSD symptom severity and mTBI (P = .04).

Conclusion:
PTSD symptom severity influences perceptions about mTBI and non-TBIs sustained during deployment. Altering injury perceptions may be an important treatment target for Veterans with co-occurring PTSD and deployment-related injuries.
A Review of Ocular Graft-Versus-Host Disease
Authors: Munir Saleha Z. , Aylward James 
Published: April 2017

ABSTRACT

Graft-versus-host disease (GVHD) is a major complication that occurs following allogeneic hematopoietic stem cell transplantation, which is a potential curative therapy used in a variety of malignant or benign hematological diseases. Graft-versus-host disease primarily occurs in many organs, but most notably in the skin, lungs, gastrointestinal tract, liver, eyes, mucosa, and musculoskeletal system. Ocular manifestations of GVHD may precede other systemic GVHD findings, and it may be a poor prognosis for mortality. While all parts of the eye may be affected, ocular GVHD occurs primarily in the ocular surface. Dry eye disease or keratoconjunctivitis sicca is the most common presenting manifestation of chronic ocular GVHD. Dry eye disease in ocular GVHD is a multifactorial process, which involves destruction and fibrosis of lacrimal glands and conjunctiva, leading to tear film deficiency and instability. Depending on the severity of ocular involvement and response to treatment, ocular GVHD may cause decreased quality of life. Management of GVHD begins with prevention by understanding risk factors and by implementing prophylactic treatment after allogeneic hematopoietic stem cell transplantation. A multidisciplinary approach to the prevention and treatment of GVHD is important, and there are currently no preventive therapies available for ocular GVHD. Once diagnosed, ocular GVHD treatment strategies target ocular surface lubrication and support, tear film stabilization, inflammation reduction, and surgical intervention. The goal of this review is to define ocular GVHD and its categorical manifestations, as well as to describe the importance of comprehensive assessment, diagnosis, and ophthalmologic treatment and management of ocular GVHD with a multidisciplinary approach.
Fear Generalization as Threat Prediction: Adaptive Changes in Facial Exploration Strategies revealed by Fixation-Pattern Similarity Analysis
Authors: Kampermann Lea , Wilming Niklas , Alink Arjen , Büchel Christian , Onat Selim 
Published: April 2017

AbstractAnimals can effortlessly adapt their behavior by generalizing from past experiences, and avoid harm in novel aversive situations. In our current understanding, the perceptual similarity between learning and generalization samples is viewed as one major factor driving aversive generalization. Alternatively, the threat-prediction account proposes that perceptual similarity should lead to generalization to the extent it predicts harmful outcomes. We tested these views using a two-dimensional perceptual continuum of faces. During learning, one face is conditioned to predict a harmful event, whereas the most dissimilar face stays neutral; introducing an adversity gradient defined only along one dimension. Learning changed the way how humans sampled information during viewing of faces. These occurred specifically along the adversity gradient leading to an increased dissimilarity of eye-movement patterns along the threat-related dimension. This provides evidence for the threat-prediction account of generalization, which conceives perceptual factors to be relevant to the extent they predict harmful outcomes.
Decoding the Brain: Neural Representation and the Limits of Multivariate Pattern Analysis in Cognitive Neuroscience
Authors: Ritchie J. Brendan , Kaplan David Michael , Klein Colin 
Published: April 2017

AbstractSince its introduction, multivariate pattern analysis (MVPA), or “neural decoding”, has transformed the field of cognitive neuroscience. Underlying its influence is a crucial inference, which we call the Decoder’s Dictum: if information can be decoded from patterns of neural activity, then this provides strong evidence about what information those patterns represent. Although the Dictum is a widely held and well-motivated principle in decoding research, it has received scant philosophical attention. We critically evaluate the Dictum, arguing that it is false: decodability is a poor guide for revealing the content of neural representations. However, we also suggest how the Dictum can be improved on, in order to better justify inferences about neural representation using MVPA.
Surgically disconnected temporal pole exhibits resting functional connectivity with remote brain regions
Authors: Warren David E. , Sutterer Matthew J. , Bruss Joel , Abel Taylor J. , Jones Andrew , Kawasaki Hiroto , Voss Michelle , Cassell Martin , Howard Matthew A. , Tranel Daniel 
Published: April 2017

AbstractFunctional connectivity, as measured by resting-state fMRI, has proven a powerful method for studying brain systems in the context of behavior, development, and disease states. However, the relationship of functional connectivity to structural connectivity remains unclear. If functional connectivity relies on structural connectivity, then anatomical isolation of a brain region should eliminate functional connectivity with other brain regions. We tested this by measuring functional connectivity of the surgically disconnected temporal pole in resection patients (N=5; mean age 37; 2F, 3M). Functional connectivity was evaluated based on coactivation of whole-brain fMRI data with the average low-frequency BOLD signal from disconnected tissue in each patient. In sharp contrast to our prediction, we observed significant functional connectivity between the disconnected temporal pole and remote brain regions in each disconnection case. These findings raise important questions about the neural bases of functional connectivity measures derived from the fMRI BOLD signal.
Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys
Authors: Nelson Cody S. , Cruz Diana Vera , Tran Dollnovan , Bialas Kristy M. , Stamper Lisa , Wu Huali , Gilbert Margaret , Blair Robert , Alvarez Xavier , Itell Hannah , Chen Meng , Deshpande Ashlesha , Chiuppesi Flavia , Wussow Felix , Diamond Don J. , Vandergrift Nathan , Walter Mark R. , Barry Peter A. , Cohen-Wolkowiez Michael , Koelle Katia , Kaur Amitinder , Permar Sallie R. 
Published: April 2017

AbstractHuman cytomegalovirus (HCMV) is the most common congenital infection and a known cause of microcephaly, sensorineural hearing loss, and cognitive impairment among newborns worldwide. Natural maternal HCMV immunity reduces the incidence of congenital infection, but does not prevent the disease altogether. We employed a nonhuman primate model of congenital CMV infection to investigate the ability of preexisting antibodies to protect against placental CMV transmission. Pregnant, CD4+ T cell-depleted, rhesus CMV (RhCMV)-seronegative rhesus monkeys were treated with either standardly-produced hyperimmune globulin (HIG) from RhCMV-seropositive macaques or dose-optimized, potently RhCMV-neutralizing HIG prior to intravenous challenge with an RhCMV swarm. HIG passive infusion provided complete protection against fetal loss in both groups, and the potently-neutralizing HIG additionally inhibited placental transmission of RhCMV. Our findings suggest that antibody alone at the time of primary infection can prevent congenital CMV and therefore could be a primary target of vaccines to eliminate this neonatal infection.