bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing Natural Language Processing to Assess Quality of End-of-Life Care for Children With Cancer
Authors: Lindsay Meghan E. , de Oliveira Sophia , Sciacca Kate , Lindvall Charlotta , Ananth Prasanna J. 
Published: September 2024

PURPOSE Data on end-of-life care (EOLC) quality, assessed through evidence-based quality measures (QMs), are difficult to obtain. Natural language processing (NLP) enables efficient quality measurement and is not yet used for children with serious illness. We sought to validate a pediatric-specific EOLC-QM keyword library and evaluate EOLC-QM attainment among childhood cancer decedents. METHODS In a single-center cohort of children with cancer who died between 2014 and 2022, we piloted a rule-based NLP approach to examine the content of clinical notes in the last 6 months of life. We identified documented discussions of five EOLC-QMs: goals of care, limitations to life-sustaining treatments (LLST), hospice, palliative care consultation, and preferred location of death. We assessed performance of NLP methods, compared with gold standard manual chart review. We then used NLP to characterize proportions of decedents with documented EOLC-QM discussions and timing of first documentation relative to death. RESULTS Among 101 decedents, nearly half were minorities (Hispanic/Latinx [24%], non-Hispanic Black/African American [20%]), female (48%), or diagnosed with solid tumors (43%). Through iterative refinement, our keyword library achieved robust performance statistics (for all EOLC-QMs, F1 score = 1.0). Most decedents had documented discussions regarding goals of care (83%), LLST (83%), and hospice (74%). Fewer decedents had documented discussions regarding palliative care consultation (49%) or preferred location of death (36%). For all five EOLC-QMs, first documentation occurred, on average, >30 days before death. CONCLUSION A high proportion of decedents attained specified EOLC-QMs more than 30 days before death. Our findings indicate that NLP is a feasible approach to measuring quality of care for children with cancer at the end of life and is ripe for multi-center research and quality improvement.
Incidence and Prognostic Values in Human Epidermal Growth Factor Receptor 2-Low Expression Metastatic Breast Cancer in Southeast Asian Population: A 10-Year Retrospective Study
Authors: Dajsakdipon Thanate , Pipatsakulroj Wiriya , Dejthevaporn Thitiya 
Published: September 2024

PURPOSE Breast cancer progression varies across molecular subtypes, and treatment options for human epidermal growth factor receptor 2 (HER2)-low expression tumors are limited compared with those of HER2 overexpression tumors. Comprehensive information regarding the epidemiology and clinical outcomes of metastatic HER2-low expression breast cancer in a Southeast Asian population is lacking. METHODS This retrospective cohort study was performed to analyze data from patients with de novo advanced breast cancer, including HER2 expression, tumor stage, and metastatic pattern. Statistical analyses, including chi-square tests and survival analyses, were used to compare HER2-low expression and HER2-negative groups. RESULTS Of the 491 patients, 21.2% had HER2-low expression, 30% had HER2 overexpression, and 50% had HER2-negative expression. Among the hormone receptor (HR)–positive patients, 34% had HER2-low expression; in the triple-negative patients, the HER2-low incidence was 20.6%. No significant differences in clinical characteristics between HER2-low and HER2-negative groups were observed, except for more HR-positive patients in the HER2-low group. HER2-low patients had a longer overall survival (OS) than HER2-negative patients (43 v 23 months; hazard ratio, 0.7; P < .001), especially in HR-positive patients. After adjusting for HR status, HER2-low patients maintained improved outcomes. HR-positive HER2-low patients showed nonsignificant OS gains compared with HR-positive HER2-negative patients, regardless of first-line chemotherapy or endocrine therapy. CONCLUSION This study revealed the incidence and clinical outcomes of HER2-low expression in de novo advanced breast cancer, suggesting favorable outcomes, particularly in HR-positive breast cancer. These findings may inform personalized treatment strategies. Further research into the mechanisms and implications of HER2-low expression in breast cancer is required.
Five Banners
Authors: Feinstein John 
Published: September 2024

On an early morning in 1983, after the worst loss of his career (109-66 against Virginia) and amid the cries of powerful athletics boosters calling for him to be fired, Duke men’s basketball coach Mike Krzyzewski went to breakfast at 2:00 a.m. to vent with friends. Sports journalist and Duke alumnus John Feinstein was at the table. For Coach K, “the night at Denny’s” would mark a turning point in his career and for the team, and eight years later, the Blue Devils would win their first NCAA national championship.
In Five Banners, Feinstein tells the inside history of Coach K’s forty-two-year career at Duke and its five NCAA championships, from the first, against Kansas in 1991, to the most recent, in 2015 against Wisconsin. With unparalleled access to Coach K, the team, and its staff, Feinstein takes readers on a mesmerizing ride into the locker room and onto the court. Full of intimate details, personal memories, and previously untold on- and off-court stories, it is a book that only Feinstein could write.
Feinstein explores a basketball legacy that begins with his days as an undergrad Duke Chronicle reporter covering coaches Bucky Waters and Neill McGeachy (who went 10-16 in one year as head coach), includes the “drought years” of the 1980s and the glory of the teams of the 1990s, and moves into the present day with Jon Scheyer’s succession. Drawing on new interviews, Feinstein highlights the voices of Grant Hill, Nolan Smith, Christian Laettner, Tommy Amaker, and Bobby Hurley, who each bring new insights on the championship years.
Throughout, Feinstein unveils the momentous force of college basketball as a game of intense relationships and intimate conversations. Candid, revelatory, and engrossing, Five Banners is an essential book for all Duke fans and anyone who loves the college game.
Understanding the Importance of Blood-Brain Barrier Alterations in Brain Arteriovenous Malformations and Implications for Treatment: A Dynamic Contrast-Enhanced-MRI–Based Prospective Study
Authors: Mosteiro Alejandra , Pedrosa Leire , Amaro Sergio , Menéndez-Girón Sebastián , Reyes Luis , de Riva Nicolás , Misis Maite , Blasco Jordi , Vert Carla , Dominguez Carlos J. , Enseñat Joaquim , Martín Abraham , Rodriguez-Hernández Ana , Torné Ramon 
Published: September 2024

BACKGROUND AND OBJECTIVES:
The major clinical implication of brain arteriovenous malformations (bAVMs) is spontaneous intracranial hemorrhage. There is a growing body of experimental evidence proving that inflammation and blood-brain barrier (BBB) dysfunction are involved in both the clinical course of the disease and the risk of bleeding. However, how bAVM treatment affects perilesional BBB disturbances is yet unclear.

METHODS:
We assessed the permeability changes of the BBB using dynamic contrast-enhanced MRI (DCE-MRI) in a series of bAVMs (n = 35), before and at a mean of 5 (±2) days after treatment. A set of cerebral cavernous malformations (CCMs) (n = 16) was used as a control group for the assessment of the surgical-related collateral changes. The extended Tofts pharmacokinetic model was used to extract permeability (Ktrans) values in the lesional, perilesional, and normal brain tissues.

RESULTS:
In patients with bAVM, the permeability of BBB was higher in the perilesional of bAVM tissue compared with the rest of the brain parenchyma (mean Ktrans 0.145 ± 0.104 vs 0.084 ± 0.035, P = .004). Meanwhile, no significant changes were seen in the perilesional brain of CCM cases (mean Ktrans 0.055 ± 0.056 vs 0.061 ± 0.026, P = .96). A significant decrease in BBB permeability was evident in the perilesional area of bAVM after surgical resection (mean Ktrans 0.145 ± 0.104 vs 0.096 ± 0.059, P = .037). This benefit in BBB permeability reduction after surgery seemed to surpass the relative increase in permeability inherent to the surgical manipulation.

CONCLUSION:
In contrast to CCMs, BBB permeability in patients with bAVM is increased in the perilesional parenchyma, as assessed using DCE-MRI. However, bAVM surgical resection seems to reduce BBB permeability in the perilesional tissue. No evidence of the so-called breakthrough phenomenon was detected in our series. DCE-MRI could become a valuable tool to follow the longitudinal course of BBB damage throughout the natural history and clinical course of bAVMs.
Ο θεσμός του Μέντορα στην εκπαιδευτική διαδικασία
Authors: Μαρτίνου Σωτηρία 
Published: September 2024

Από το σχολικό έτος 2022-23 εισάγεται ο θεσμός του μέντορα στην Πρωτοβάθμια και τη Δευτεροβάθμια Εκπαίδευση. Σκοπός της παρούσας εργασίας είναι να παρουσιάσουμε τη μεντορεία και να αναδείξουμε τη σημαντικότητά της για τους/τις νεοεισερχόμενους/ες εκπαιδευτικούς. Θα γνωρίσουμε τα καθήκοντα και τις αρμοδιότητες των μεντόρων, τη θητεία, τα κριτήρια ορισμού και τον τρόπο επιλογής τους. Στην εργασία μας, θα γίνει εστίαση στις ανάγκες υποστήριξης των νεοεισερχόμενων εκπαιδευτικών και στα χαρακτηριστικά του μέντορα και του/της μεντορευόμενου/ης για την επιτυχία του δομημένου προγράμματος της εκπαιδευτικής καθοδήγησης των νεοεισερχόμενων εκπαιδευτικών. Θα αναδειχθούν, επίσης, τα στάδια της μεντορικής σχέσης, τα οφέλη από τους εμπλεκόμενους στο mentoring και η συμβολή του θεσμού του μέντορα στη διαμόρφωση της διδασκαλίας, ως διαδικασία επαγγελματικής μάθησης και ανάπτυξης των εκπαιδευτικών. Θα αιτιολογηθεί, παράλληλα η αποτελεσματικότητα της μεντορικής διαδικασίας μέσα από την αυτοαξιολόγηση των συμμετεχόντων/ουσών, τη διαμορφωτική και την τελική αξιολόγηση στη μεντορεία.
Το Πλαίσιο του Θαλάσσιου Χωροταξικού Σχεδιασμού: Μια Μελέτη Περίπτωσης για την Βιωσιμότητα του Βορείου, Νοτίου Αιγαίου & Κρήτης
Authors: Παυλογεωργάτος Γεράσιμος , Κόκκινου Αικατερίνη 
Published: September 2024

Περίληψη
Ο θαλάσσιος χωροταξικός σχεδιασμός αποτελεί ένα στρατηγικό ολοκληρωμένο σχέδιο που στοχεύει στην ενσωμάτωση των χρήσεων της θαλάσσιας ζώνης και των παράκτιων δραστηριοτήτων με απώτερο σκοπό την επίτευξη της βιώσιμης και ισορροπημένη ανάπτυξη. Ο θαλάσσιος χωρικός σχεδιασμός ασχολείται με τον σχεδιασμό, την οργάνωση, τη διαχείριση και τη ‘σύνδεση’ του θαλάσσιου και του παράκτιου χώρου, έτσι ώστε να επιτευχθούν πολλαπλασιαστικές θετικές επιπτώσεις με την αξιοποίηση των πόρων, τη βιώσιμη ισόρροπη ανάπτυξη, τη προστασία του περιβάλλοντος και την κοινωνική συνοχή. Το άρθρο αυτό στοχεύει την καταγραφή, παρουσίαση και ανάλυση του πλαισίου του θαλάσσιου χωροταξικού σχεδιασμού και την συμβολή του στην ισόρροπο αειφόρο βιώσιμη ανάπτυξη. Πιο συγκεκριμένα, οι περιφέρειες που αποτελούν αντικείμενο διαχρονικής και δια-συγκριτικής μελέτης είναι η περιοχή του Αιγαίου και ιδιαίτερα το Βόρειο Αιγαίο, το Νότιο Αιγαίο και η Κρήτη.
Abstract
Maritime spatial planning is a strategic integrated plan that aims to integrate the uses of the marine zone and coastal activities with the ultimate goal of achieving sustainable and balanced development. Maritime spatial planning is concerned with planning, organizing, managing and connecting marine and coastal space, so as to achieve multiplier positive effects through resource utilization, sustainable balanced development, environmental protection and social cohesion. This paper aims to record, present and analyze the framework of marine spatial planning and its contribution to balanced sustainable development. More specifically, the regions that are the subject of a longitudinal and cross-comparative study are the Aegean region and especially North Aegean, South Aegean and Crete.
Η Μακροοικονομική Διερεύνηση της Διάβρωσης Φορολογικής Βάσης και Μετατόπισης Κερδών: Μία Συστηματική Βιβλιογραφική Ανασκόπηση
Authors: Βασιλάκης Αθανάσιος Γ. 
Published: September 2024

Περίληψη
Ο κύριος σκοπός της εργασίας είναι η Συστηματική Βιβλιογραφική Ανασκόπηση (ΣΒΑ) των μακροοικονομικών επιπτώσεων της Διάβρωσης της Φορολογικής Βάσης και της Μετατόπισης Κερδών (Base Erosion and Profit Shifting - BEPS). Η επίτευξη του σκοπού πραγματοποιήθηκε με την αξιοποίηση του πλαισίου PRISMA (Preferred Reporting Items for Systematic Reviews and Meta – Analysis). Τα επιστημονικά άρθρα αντλήθηκαν από πέντε βάσεις δεδομένων (ABI-ProQuest, EBSCO, Google Scholar, Scopus, Web of Science) που δημοσιεύθηκαν από το 2003 έως 2022. Η ΣΒΑ βασίζεται σε 30 επιλεγμένες εργασίες που αντλούνται από 16.700 πηγές (μέγιστος αναφερόμενος αριθμός από Google Scholar). Οι 30 επιλεγμένες εργασίες ανακτήθηκαν από επιστημονικά περιοδικά που είναι καταχωρημένα σε τρεις διαφορετικές ακαδημαϊκές βάσεις δεδομένων [Scopus, Chartered Association of Business Schools (ABS), Web of Science (WoS)]. Η ΣΒΑ ταξινομεί τις εξαρτημένες και ανεξάρτητες μακροοικονομικές επιπτώσεις που προκαλεί η πρακτική των BEPS, όπως η όξυνση της διεθνούς φοροαποφυγής που έχουν δυσμενή αντίκτυπο στην Παγκόσμια και Ευρωπαϊκή Οικονομία.
Abstract
A Systematic Literature Review of the Macro-Economics of Base Erosion and Profit Shifting (BEPS) is the main purpose of this study. This has been achieved by a Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) that was conducted using five databases (ABI-ProQuest, EBSCO, Google Scholar, Scopus and Web of Science) published between 2003 and 2022. This review is based on 30 studies out of 16.700 (the larger number from Google Scholar) that were identified. The chosen 30 articles were retrieved as triple listed journals on Scopus, The Chartered Association of Business Schools (ABS) and Web of Science (WoS). Our approach aims to identify the serious dependent, independent and control macroeconomic issues that BEPS causes, such as severe acute international tax avoidance that has a destructive impact on the Global and European economies.
COVID-19 challenges: how ICT successfully allowed adaptation of Drama in Education experiential method during PhD research
Authors: Zourna Christina , Papavassiliou Ioanna , Koutsoupias Nikos 
Published: September 2024

Abstract
The COVID-19 pandemic outburst in March 2020 caused unexpected changes in the means, ways, methods that teaching, training, and learning usually take place. Teachers and educators around the globe gradually turned towards remote teaching methods taking advantage of the latest innovations in ICT and widely recognized internet platforms to meet those emerging needs; however, this shift provoked unforeseen and previously unmet challenges, especially in the cases of theater and drama, known until then as totally experiential and face-to-face facilitated. The current article focuses on the changes that were intentionally adopted concerning adaptation of methods and applications during a PhD research based on Drama in Education, that allowed effective remote intervention and successful continuation of the research. Appropriate career theories and the adaptability of DiE method helped the researchers to remain open-minded, flexible, and proactive, follow emerging unknown paths, and develop their coping, digital, research management, and professional skills.
Keywords: Drama in Education, COVID-19 pandemic, professional development, career coping skills, adaptation of methodology
Adaptive Two-Stage Stochastic Programming with an Analysis on Capacity Expansion Planning Problem
Authors: Basciftci Beste , Ahmed Shabbir , Gebraeel Nagi 
Published: September 2024

Problem definition: Multistage stochastic programming is a well-established framework for sequential decision making under uncertainty by seeking policies that can be dynamically adjusted as uncertainty is realized. Often, for example, because of contractual constraints, such flexible policies are not desirable, and the decision maker may need to commit to a set of actions for a certain number of periods. Two-stage stochastic programming might be better suited to such settings, where first-stage decisions do not adapt to the uncertainty realized. In this paper, we propose a novel alternative approach, named as adaptive two-stage stochastic programming, where each component of the decision policy requiring limited flexibility has its own revision point, a period prior to which the decisions are determined at the beginning of the planning until this revision point, and after which they are revised for adjusting to the uncertainty realized thus far until the end of the planning. We then analyze this approach over the capacity expansion planning problem, that may require limited flexibility over expansion decisions. Methodology/results: We provide a generic mixed-integer programming formulation for the adaptive two-stage stochastic programming problem with finite support, in particular, for scenario trees, and show that this problem is NP-hard in general. Next, we focus on the capacity expansion planning problem and derive bounds on the value of adaptive two-stage programming in comparison with the two-stage and multistage approaches in terms of revision points. We propose several heuristic solution algorithms based on this bound analysis. These algorithms either provide approximation guarantees or computational advantages in solving the resulting adaptive two-stage stochastic problem. Managerial implications: We provide insights on the choice of the revision times based on our analytical analysis. We further present an extensive computational study on a generation capacity expansion planning problem with different generation resources including renewable energy. We demonstrate the value of adopting adaptive two-stage approach against the existing policies under limited flexibility and highlight the efficiency of the proposed heuristics along with practical implications on the studied problem. Funding: This work was supported by the National Science Foundation [Grant 1633196] and the Office of Naval Research [Grant N00014-18-1-2075]. Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2023.0157 .
Demand Equilibria in Spatial Service Systems
Authors: Gunnar Carlsson John , Peng Xiaoshan , Ryzhov Ilya O. 
Published: September 2024

Problem definition: A service is offered at certain locations (“facilities”) in a geographical region. Customers can appear anywhere in the region, and each customer chooses a facility based on travel distance as well as expected waiting time. Customer decisions affect waiting times by increasing the load on a facility, and thus, they impact other customers’ decisions. The service provider can also influence service quality by adjusting service rates at each facility. Methodology/results: Using a combination of queueing models and computational geometry, we characterize demand equilibria in such spatial service systems. An equilibrium can be visualized as a partition of the region into service zones that form as a result of customer decisions. Service rates can be set in a way that achieves the best-possible social welfare purely through decentralized customer behavior. Managerial implications: We provide techniques for computing and visualizing demand equilibria as well as calculating optimal service rates. Our analytical and numerical results indicate that in many situations, resource allocation is a far more significant source of inefficiency than decentralized behavior. Funding: J. G. Carlsson was funded by the METRANS Transportation Consortium [Grant NCST-USC-RR-24-12] and the Office of Naval Research [Grant N00014-24-1-2277-P00001]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.0434 .
Metastatic Oral Cancer and the Importance of a thorough Neck Examination
Authors: Biyani Prateek , Xu Jimmy , Anabtawi Mohammed , Orr Robert 
Published: September 2024

Squamous cell carcinomas (SCC) account for over 90% of oral cancers. Over the last few decades, there has been a significant increase in the number of cases. Metastasis of oral cancer to the thyroid is extremely rare. Rarer still are tumours metastasizing from the tongue to the thyroid. We present a case of a patient who presented to her dentist with a tongue SCC. Despite radical curative treatment, the tumour metastasized to the thyroid and the patient succumbed to the metastatic disease. We, additionally, highlight the importance of thorough lymph node and neck examination in the dental setting to help identify pathology in patients. CPD/Clinical Relevance: The importance of a thorough lymph node and neck examination at routine dental check-ups is highlighted.
Systemic Conditions associated with Delayed Tooth Eruption
Authors: Hirst Lorna , Mubeen Suhaym , Evans Robert 
Published: September 2024

Tooth eruption comprises a highly coordinated cascade of complex cellular and molecular interactions resulting in axial movement of the tooth germ from an intra-osseous position to its functional occlusion. Odontogenesis is under genetic control, governed by more than 300 genes, with environmental factors playing a comparatively minor role. Delayed tooth eruption (DTE) describes the most frequently encountered deviation from normal eruption and can be the solitary materialization of local or systemic pathology. Where local pathology has been excluded, the dentist should be aware of the multitude of systemic conditions that may be contributing, and liaise with relevant medical colleagues. This article provides a review of the literature regarding the systemic causes of DTE. CPD/Clinical Relevance: Systemic conditions can be aetiological factors in delayed tooth eruption.
Surgical Guides for Implant Therapy
Authors: Domah Farya , Shah Raunaq 
Published: September 2024

Ideal prosthetic and aesthetic results in implant therapy results from successful implant placement. Such success depends on a number of factors; one of which is the accurate transfer of information from the planning stage to the surgical field. Surgical templates are instrumental in allowing such transfer of information. This article aims to review various designs of implant guides and their accuracy. CPD/Clinical Relevance: A surgical guide allows precise implant placement for predictable implant therapy outcomes.
Assessing the fragility index of randomized controlled trials supporting perioperative care guidelines: A methodological survey protocol
Authors: Otalora-Esteban Margarita , Delgado-Ramirez Martha Beatriz , Gil Fabian , Thabane Lehana 
Published: September 2024

Introduction
The Fragility Index (FI) and the FI family are statistical tools that measure the robustness of randomized controlled trials (RCT) by examining how many patients would need a different outcome to change the statistical significance of the main results of a trial. These tools have recently gained popularity in assessing the robustness or fragility of clinical trials in many clinical areas and analyzing the strength of the trial outcomes underpinning guideline recommendations. However, it has not been applied to perioperative care Clinical Practice Guidelines (CPG).

Objectives
This study aims to survey clinical practice guidelines in anesthesiology to determine the Fragility Index of RCTs supporting the recommendations, and to explore trial characteristics associated with fragility.

Methods and analysis
A methodological survey will be conducted using the targeted population of RCT referenced in the recommendations of the CPG of the North American and European societies from 2012 to 2022. FI will be assessed for statistically significant and non-significant trial results. A Poisson regression analysis will be used to explore factors associated with fragility.

Discussion
This methodological survey aims to estimate the Fragility Index of RCTs supporting perioperative care guidelines published by North American and European societies of anesthesiology between 2012 and 2022. The results of this study will inform the methodological quality of RCTs included in perioperative care guidelines and identify areas for improvement.