bluuebunny/crossref_metadata_2025_split huggingface dataset:
Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2015 Treatment Recommendations for Psoriatic Arthritis
Authors: Coates Laura C. , Kavanaugh Arthur , Mease Philip J. , Soriano Enrique R. , Laura Acosta‐Felquer Maria , Armstrong April W. , Bautista‐Molano Wilson , Boehncke Wolf‐Henning , Campbell Willemina , Cauli Alberto , Espinoza Luis R. , FitzGerald Oliver , Gladman Dafna D. , Gottlieb Alice , Helliwell Philip S. , Husni M. Elaine , Love Thorvardur J. , Lubrano Ennio , McHugh Neil , Nash Peter , Ogdie Alexis , Orbai Ana‐Maria , Parkinson Andrew , O'Sullivan Denis , Rosen Cheryl F. , Schwartzman Sergio , Siegel Evan L. , Toloza Sergio , Tuong William , Ritchlin Christopher T. 
Published: January 2016

ObjectiveTo update the 2009 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations for the spectrum of manifestations affecting patients with psoriatic arthritis (PsA).MethodsGRAPPA rheumatologists, dermatologists, and PsA patients drafted overarching principles for the management of PsA, based on consensus achieved at face‐to‐face meetings and via online surveys. We conducted literature reviews regarding treatment for the key domains of PsA (arthritis, spondylitis, enthesitis, dactylitis, skin disease, and nail disease) and convened a new group to identify pertinent comorbidities and their effect on treatment. Finally, we drafted treatment recommendations for each of the clinical manifestations and assessed the level of agreement for the overarching principles and treatment recommendations among GRAPPA members, using an online questionnaire.ResultsSix overarching principles had ≥80% agreement among both health care professionals (n = 135) and patient research partners (n = 10). We developed treatment recommendations and a schema incorporating these principles for arthritis, spondylitis, enthesitis, dactylitis, skin disease, nail disease, and comorbidities in the setting of PsA, using the Grading of Recommendations, Assessment, Development and Evaluation process. Agreement of >80% was reached for approval of the individual recommendations and the overall schema.ConclusionWe present overarching principles and updated treatment recommendations for the key manifestations of PsA, including related comorbidities, based on a literature review and consensus of GRAPPA members (rheumatologists, dermatologists, other health care providers, and patient research partners). Further updates are anticipated as the therapeutic landscape in PsA evolves.
Brief Report: Proatherogenic Cytokine Microenvironment in the Aortic Adventitia of Patients With Rheumatoid Arthritis
Authors: Ahmed Ammad , Hollan Ivana , Curran Samuel A. , Kitson Susan M. , Riggio Marcello P. , Mikkelsen Knut , Almdahl Sven M. , Aukrust Pål , McInnes Iain B. , Goodyear Carl S. 
Published: January 2016

ObjectivePatients with rheumatoid arthritis (RA) are at increased risk of developing cardiovascular disease (CVD) via mechanisms that have not yet been defined. Inflammatory pathways, in particular within the vascular adventitia, are implicated in the pathogenesis of primary CVD but could be amplified in RA at the local tissue level. The aim of this study was to examine the aortic adventitia of coronary artery disease (CAD) patients with or without RA to determine the cytokine profile contained therein.MethodsAortic adventitia and internal thoracic artery biopsy specimens obtained from 19 RA patients and 20 non‐RA patients undergoing coronary artery bypass graft surgery were examined by immunohistochemistry.ResultsInterleukin‐18 (IL‐18), IL‐33, and tumor necrosis factor (TNF) were expressed in aortic adventitia biopsy specimens from both groups, and expression of these cytokines was significantly higher in RA patients. In RA patients, IL‐33 expression in endothelial cells correlated positively with the number of swollen joints, suggesting a link between the systemic disease state and the local vascular tissue microlesion.ConclusionThe presence of the proinflammatory cytokines IL‐18, IL‐33, and TNF may play a role in the inflammatory process within the adventitia that contributes to plaque formation and destabilization. In theory, the amplified expression of these cytokines may contribute to the known increased occurrence and severity of CAD in patients with RA.
Netrin‐1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin‐Induced Pulmonary Fibrosis
Authors: Sun Huanxing , Zhu Yangyang , Pan Hongyi , Chen Xiaosong , Balestrini Jenna L. , Lam TuKiet T. , Kanyo Jean E. , Eichmann Anne , Gulati Mridu , Fares Wassim H. , Bai Hanwen , Feghali‐Bostwick Carol A. , Gan Ye , Peng Xueyan , Moore Meagan W. , White Eric S. , Sava Parid , Gonzalez Anjelica L. , Cheng Yuwei , Niklason Laura E. , Herzog Erica L. 
Published: January 2016

Objective Fibrocytes are collagen‐producing leukocytes that accumulate in patients with systemic sclerosis (SSc; scleroderma)–related interstitial lung disease (ILD) via unknown mechanisms that have been associated with altered expression of neuroimmune proteins. The extracellular matrix (ECM) influences cellular phenotypes. However, a relationship between the lung ECM and fibrocytes in SSc has not been explored. The aim of this study was to use a novel translational platform based on decellularized human lungs to determine whether the lung ECM of patients with scleroderma controls the development of fibrocytes from peripheral blood mononuclear cells.Methods We performed biomechanical evaluation of decellularized scaffolds prepared from lung explants from healthy control subjects and patients with scleroderma, using tensile testing and biochemical and proteomic analysis. Cells obtained from healthy controls and patients with SSc‐related ILD were cultured on these scaffolds, and CD45+pro‐ColIα1+ cells meeting the criteria for fibrocytes were quantified. The contribution of the neuromolecule netrin‐1 to fibrosis was assessed using neutralizing antibodies in this system and by administering bleomycin via inhalation to netrin‐1+/− mice.ResultsCompared with control lung scaffolds, lung scaffolds from patients with SSc‐related ILD showed aberrant anatomy, enhanced stiffness, and abnormal ECM composition. Culture of control cells in lung scaffolds from patients with SSc‐related ILD increased production of pro‐ColIα1+ cells, which was stimulated by enhanced stiffness and abnormal ECM composition. Cells from patients with SSc‐related ILD demonstrated increased pro‐ColIα1 responsiveness to lung scaffolds from scleroderma patients but not enhanced stiffness. Enhanced detection of netrin‐1–expressing CD14low cells in patients with SSc‐related ILD was observed, and antibody‐mediated netrin‐1 neutralization attenuated detection of CD45+pro‐ColIα1+ cells in all settings. Netrin‐1+/− mice were protected against bleomycin‐induced lung fibrosis and fibrocyte accumulation.ConclusionFactors present in the lung matrices of patients with scleroderma regulate fibrocyte accumulation via a netrin‐1–dependent pathway. Netrin‐1 regulates bleomycin‐induced pulmonary fibrosis in mice. Netrin‐1 might be a novel therapeutic target in SSc‐related ILD.
Silent Monosodium Urate Crystal Deposits Are Associated With Severe Coronary Calcification in Asymptomatic Hyperuricemia: An Exploratory Study
Authors: Andrés Mariano , Quintanilla María‐Amparo , Sivera Francisca , Sánchez‐Payá José , Pascual Eliseo , Vela Paloma , Ruiz‐Nodar Juan‐Miguel 
Published: January 2016

ObjectiveTo evaluate the association between monosodium urate (MSU) crystal deposits in patients with asymptomatic hyperuricemia and the severity and extension of coronary artery disease (CAD).MethodsIn this cross‐sectional study, consecutive inpatients with a non–ST elevation acute coronary event and asymptomatic hyperuricemia (serum uric acid concentration of ≥7.0 mg/dl) or normouricemia (serum uric acid concentration of <7.0 mg/dl) were enrolled. In patients with asymptomatic hyperuricemia, the presence of MSU crystals was determined by ultrasound evaluation of both knees and first metatarsophalangeal joints and by compensated polarized light microscopy. CAD was assessed by coronary angiography, and the following variables were considered: 1) the presence of moderate‐to‐severe coronary artery calcification, 2) the number of significant coronary stenoses, and 3) the presence of multivessel disease. The association between variables indicating the severity of CAD and the presence of MSU crystals was analyzed by multivariate regression.ResultsOne hundred forty patients were enrolled. After ultrasonography and microscopic analyses were performed, the patients were classified as having normouricemia (n = 66), asymptomatic hyperuricemia alone (n = 61), and asymptomatic hyperuricemia with MSU crystals (n = 13). The prevalence of moderate‐to‐severe coronary calcification was significantly higher in the patients with asymptomatic hyperuricemia with MSU crystals compared with patients with asymptomatic hyperuricemia alone and patients with normouricemia (P = 0.003). An independent association was observed between the presence of moderate‐to‐severe calcification and asymptomatic hyperuricemia with crystals (odds ratio 16.8, P = 0.002). No significant association was observed for the other variables.ConclusionSilent deposition of MSU crystals in patients with asymptomatic hyperuricemia was associated with more severe coronary calcification, which suggests more severe CAD in relation to crystal deposition.
A Meta‐Analysis to Estimate the Placebo Effect in Randomized Controlled Trials in Juvenile Idiopathic Arthritis
Authors: Demirkaya Erkan , Lanni Stefano , Bovis Francesca , Galasso Roberta , Ravelli Angelo , Palmisani Elena , Consolaro Alessandro , Pederzoli Silvia , Marafon Denise , Simianer Stefan , Martini Alberto , Ruperto Nicolino , Pistorio Angela ,   for the Paediatric Rheumatology International Trials Organisation
Published: January 2016

ObjectiveTo estimate the placebo effect in juvenile idiopathic arthritis (JIA) through a meta‐analysis of phase III clinical trials with placebo comparator.MethodsA systematic literature search was carried out up to December 2014. For parallel design studies the outcome was evaluated as a single 1‐dimensional (1‐D) variable or as a composite score; outcomes of withdrawal studies were evaluated only as composite scores.ResultsWe included 26 of 224 trials (12%). In trials with parallel study design and a 1‐D outcome, the placebo effect was 0.35 (95% confidence interval [95% CI] 0.27–0.43). Among trials with parallel study design and a composite score outcome, the placebo rate response was higher in trials that included patients with nonsystemic JIA (0.35 [95% CI 0.29–0.42]) than in trials that included only patients with systemic JIA (0.17 [95% CI 0.10–0.30]). In the withdrawal design trials, the percentages of patients receiving placebo who had disease flares during the double‐blind phase were lower in trials that included patients with nonsystemic JIA (0.55 [95% CI 0.47–0.64]) than in trials that included only patients with systemic JIA (0.68 [95% CI 0.33–0.90]).ConclusionIn trials with a parallel study design a sizable number of patients seem to benefit from a placebo effect, although this effect is smaller in patients with systemic JIA. In trials with a withdrawal design the inverse placebo effect is similar among the different JIA categories. This placebo effect should be considered when evaluating the effectiveness of proposed interventions and for future calculations of sample size.
An Approach for the Selective Detection of Nitric Oxide in Biological Systems: An in vitro and in vivo Perspective
Authors: Gupta Neha , Imam Reja Shahi , Bhalla Vandana , Gupta Muskan , Kaur Gurcharan , Kumar Manoj 
Published: January 2016

AbstractA naphthalimide‐based fluorescent probe, LyNP‐NO, was designed and synthesized for the selective detection of exogenously and endogenously generated nitric oxide (NO) in C6 glial cells. In addition, LyNP‐NO was also explored for monitoring endogenous NO levels in rat hippocampus at various tissue depths by stimulating the brain with N‐methyl‐d‐aspartate (NMDA).
Anion‐Exchange Properties of Trifluoroacetate and Triflate Salts of N‐Alkylammonium Resorcinarenes
Authors: Pan Fangfang , Beyeh Ngong Kodiah , Bertella Stefania , Rissanen Kari 
Published: January 2016

AbstractThe synthesis of N‐benzyl‐ and N‐cyclohexylammonium resorcinarene trifluoroacetate (TFA) and triflate (OTf) salt receptors was investigated. Solid‐state analysis by single‐crystal X‐ray diffraction revealed that the N‐alkylammonium resorcinarene salts (NARSs) with different upper substituents had different cavity sizes and different affinities for anions. Anion‐exchange experiments by mixing equimolar amounts of N‐benzylammonium resorcinarene trifluoroacetate and N‐cyclohexylammonium resorcinarene triflate, as well as N‐benzylammonium resorcinarene triflate and N‐cyclohexylammonium resorcinarene trifluoroacetate showed that the NARS with flexible benzyl groups preferred the larger OTf anion, whereas the rigid cyclohexyl groups preferred the smaller TFA anions. The anion‐exchange processes were confirmed in the solid state by single‐crystal and powder X‐ray diffraction experiments and in the gas phase by electrospray ionization mass spectrometry.
Controllability and Observability of Parallel Magnetic Suspension Systems
Authors: Mizuno Takeshi , Takasaki Masaya , Ishino Yuji 
Published: January 2016

AbstractThe controllability and observability of parallel magnetic suspension systems are investigated analytically. A parallel magnetic suspension system has multiple floators and electromagnets driven by a single amplifier. In this paper, the multiplicity is set to an arbitrary counting number n. Parallel systems are classified into four types based on the output of the power amplifier and the connection of the coils. This paper treats three of them: current‐controlled with series‐connected coils; voltage‐controlled with series‐connected coils; and voltage‐controlled with parallel‐connected coils. The conditions of controllability and observability of each system are clarified. The feasibility of parallel magnetic suspension is demonstrated by simulations and experiments.
Feed additive production by fermentation of herbPolygonum hydropiperL. and cassava pulp with simultaneous flavonoid dissolution
Authors: Song Zhen‐Tao , Zhu Ming‐Jun 
Published: January 2016

AbstractFermentation of herbPolygonum hydropiperL. (PHL) and cassava pulp (CP) for feed additive production with simultaneous flavonoid dissolution was investigated, and a two‐stage response surface methodology (RSM) based on Plackett−Burman factorial design (PB design) was used to optimize the flavonoid dissolution and protein content. Using the screening function of PB design, four different significant factors for the two response variables were acquired: factors A (CP) and B (PHL) for the flavonoid dissolution versus factors G (inoculum size) and H (fermentation time) for protein content. Then, two RSMs were used sequentially to improve the values of the two response variables separately. The mutual corroboration of the experimental results in the present study confirmed the validity of the associated experimental design. The validation experiment showed a flavonoid dissolution rate of 94.00%, and a protein content of 18.20%, gaining an increase in 21.20% and 199.10% over the control, respectively. The present study confirms the feasibility of feed additive productionby Saccharomyces cerevisiaewith CP and PHL and simultaneous optimization of flavonoid dissolution and protein content using a two‐stage RSM.
Synthesis of pH‐responsive β‐CD‐based star polymer and impact of its self‐assembly behavior on pectinase activity
Authors: Hu Dong , Yang Hong , Liu Jiangtao , Lei Zhongli 
Published: January 2016

AbstractA novel type of pH‐responsive star polymer based on β‐cyclodextrin (β‐CD) was synthesized and further covalently conjugated with enzyme. The impact of its self‐assembly behavior on enzyme activity was investigated. In our design, azide containing the polymer (N3)7‐β‐CD‐(PtBA)14 was synthesized via atom transfer radical polymerization of tert‐butyl acrylate using (N3)7‐β‐CD‐(Br)14 as the multifunctional initiator. The final product (N3)7‐β‐CD‐(PAA)14 was obtained via hydrolysis and covalently conjugating pectinase onto pH‐responsive polyacrylic acid (PAA) arms. PAA can change its conformation with the self‐assembly by altered pH, leading its nanostructure into micellar nanoparticles in aqueous solution and further affecting the activity of immobilized pectinase. The results were proved by fluorescence spectroscopy and dynamic light scattering. This system proves that the activity of immobilized enzyme can be tailored predictably, and this pH‐responsive polymer holds great potential for controllable delivery of enzymes.
Techno‐economic assessment of the effect of torrefaction on fast pyrolysis of pine
Authors: Winjobi Olumide , Shonnard David R. , Bar‐Ziv Ezra , Zhou Wen 
Published: January 2016

AbstractTechno‐economic assessment of bio‐oil production from fast pyrolysis of pine was explored through process simulation. In this work, bio‐oil production via a one‐step pyrolysis route and a two‐step pyrolysis which included a torrefaction step before fast pyrolysis were modeled to process 1000 MT/day of dry feed (dry basis) through the pyrolyzer at a temperature of 530 °C while two‐step ‐pyrolysis was investigated at three different torrefaction temperatures of 290, 310, and 330 °C. Different scenarios that included the use of fossil energy to produce process heat as well as use of renewable energy either through the combustion of char or a portion of the condensates from ‐torrefaction were also investigated. Economic analysis indicates that a torrefaction step results in a reduction in the minimum selling price of bio‐oil produced which reduced further with ‐torrefaction ‐temperature with lowest bio‐oil price of $1.04/gal obtained for a two‐step pyrolysis at torrefaction ‐temperature of 330 °C in comparison to $1.32/gal for a one‐step process. Minimum selling price of bio‐oil on an energy basis however suggests a higher price of about $22.19/GJ for a two‐step in ‐comparison to $16.89/GJ for a one‐step. There could be a trade‐offs between the higher quality and the higher selling price considering the downstream upgrade step to hydrocarbon fuel. © 2016 Society of Chemical Industry and John Wiley & Sons, Ltd
Five recommendations to kick‐start bioeconomy innovation in the UK
Authors: Burns Caitlin , Higson Adrian , Hodgson Edward 
Published: January 2016

IntroductionThe UK’s bioeconomy has the potential to be world leading. However, political, economic, and social barriers are holding back innovation in this sector. Key interventions are needed to allow bioeconomic innovation to flourish. Caitlin Burns and Adrian Higson of the NNFCC The Bioeconomy Consultants, and Edward Hodgson of Aberystwyth University, make five recommendations to help the UK catch up with global competitors and stimulate investment in innovative bioeconomy. © 2016 Society of Chemical Industry and John Wiley & Sons, Ltd
Effect of dietary fibers on losartan uptake and transport in Caco‐2 cells
Authors: Iwazaki Ayano , Takahashi Naho , Miyake Reiko , Hiroshima Yuka , Abe Mariko , Yasui Airi , Imai Kimie 
Published: January 2016

AbstractThe objective of this study was to assess the effect of dietary fibers on the transport of losartan, an angiotensin II type 1 receptor blocker, in small intestinal cells. Using Caco‐2 cells in vitro, losartan uptake and transport were evaluated in the presence of various fibers (cellulose, chitosan, sodium alginate and glucomannan). Dietary fibers caused a decrease in the uptake of losartan, with chitosan causing a significant reduction. Chitosan and glucomannan significantly reduced the transport of losartan, while cellulose or sodium alginate did not. Dietary fibers also reduced the level of free losartan; however, this did not correlate with the observed reduction in losartan uptake and transport. In summary, chitosan had the greatest inhibitory effect on losartan uptake and transport, and this potential interaction should be considered in patients taking losartan. Copyright © 2016 John Wiley & Sons, Ltd.
Structure and photoluminescent properties of green‐emitting terbium‐doped GdV1−xPxO4 phosphor prepared by solution combustion method
Authors: Motloung S. J. , Shaat S. K. K. , Tshabalala K. G. , Ntwaeaborwa O. M. 
Published: January 2016

AbstractTerbium‐doped gadolinium orthovanadate (GdVO4:Tb3+), orthophosphate monohydrate (GdPO4·H2O:Tb3+) and orthovanadate–phosphate (GdV,PO4:Tb3+) powder phosphors were synthesized using a solution combustion method. X‐Ray diffraction analysis confirmed the formation of crystalline GdVO4, GdPO4·H2O and GdV,PO4. Scanning electron microscopy images showed that the powder was composed of an agglomeration of particles of different shapes, ranging from spherical to oval to wire‐like structures. The chemical elements present were confirmed by energy dispersive spectroscopy, and the stretching mode frequencies were determined by Fourier transform infrared spectroscopy. UV–visible spectroscopy spectra showed a strong absorption band with a maximum at 200 nm assigned to the absorption of VO43− and minor excitation bands assigned to f → f transitions of Tb3+. Four characteristic emission peaks were observed at 491, 546, 588 and 623 nm, and are attributed to 5D4 → 7Fj (j = 6, 5, 4 and 3). The photoluminescent prominent green emission peak (5D4 → 7F5) was centred at 546 nm. The structure and possible mechanism of light emission from GdV1−xPxO4:% Tb3+ are discussed. Copyright © 2016 John Wiley & Sons, Ltd.
Integrated process for high conversion and high yield protein PEGylation
Authors: Pfister David , Morbidelli Massimo 
Published: January 2016

ABSTRACTOver the past decades, PEGylation has become a powerful technique to increase the in vivo circulation half‐life of therapeutic proteins while maintaining their activity. The development of new therapeutic proteins is likely to require further improvement of the PEGylation methods to reach even better selectivity and yield for reduced costs. The intensification of the PEGylation process was investigated through the integration of a chromatographic step in order to increase yield and conversion for the production of mono‐PEGylated protein. Lysozyme was used as a model protein to demonstrate the feasibility of such approach. In the integrated reaction/separation process, chromatography was used as fractionation technique in order to isolate and recycle the unreacted protein from the PEGylated products. This allows operating the reactor with short reaction times so as to minimize the production of multi‐PEGylated proteins (i.e., conjugated to more than one polymer). That is, the reaction is stopped before the desired product (i.e., the mono‐PEGylated protein) can further react, thus leading to limited conversion but high yield. The recycling of the unreacted protein was then considered to drive the protein overall conversion to completion. This approach has great potential to improve processes whose yield is limited by the further reaction of the product leading to undesirable by‐products. Biotechnol. Bioeng. 2016;113: 1711–1718. © 2016 Wiley Periodicals, Inc.