bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Plain Sight: The Neglected Linkage between Brideprice and Violent Conflict
Authors: Hudson Valerie M. , Matfess Hilary 
Published: August 2017

AbstractApproximately seventy-five percent of the world's population lives in countries where asset exchange upon marriage is obligatory. Rising brideprice—money or gifts provided to a woman's family by the groom and his family as part of marriage arrangements—is a common if overlooked catalyst of violent conflict. In patrilineal (and some matrilineal) societies where brideprice is practiced, a man's social status is directly connected to his marital status. Brideprice acts as a flat tax that is prone to sudden and swift increases. As a result, rising brideprice can create serious marriage market distortions that prevent young men, especially those who are poor or otherwise marginalized, from marrying. This phenomenon is especially evident in polygamous societies, where wealthy men can afford more than one bride. These distortions incentivize extra-legal asset accumulation, whether through ad hoc raiding or organized violence. In such situations, rebel and terror groups may offer to pay brideprice—or even provide brides—to recruit new members. Descriptive case studies of Boko Haram in Nigeria and various armed groups in South Sudan demonstrate these linkages, while an examination of Saudi Arabia's cap on brideprice and its efforts to arrange low-cost mass weddings illustrates the ways in which governments can intervene in marriage markets to help prevent brideprice-related instability. The trajectory of brideprice is an important but neglected early indicator of societal instability and violent conflict, underscoring that the situation and security of women tangibly affect national security.
Age structure, growth pattern, sexual maturity, and longevity of Leptodactylus latrans (Anura: Leptodactylidae) in temperate wetlands
Authors: López Javier A. , Antoniazzi Carolina E. , Llanes Roxana E. , Ghirardi Romina 
Published: August 2017

We present the first data on age structure, growth pattern, and lines of arrested growth (LAG) forLeptodactylus latransin temperate wetlands. Based on these data, we estimate LAG periodicity, age, size at sexual maturity and longevity for this species. We also tested for differences of these parameters between sexes. The age was determined through skeletochronology. Female maturity was determined by presence of differentiated ova, while male maturity was assessed through histological analysis to evaluate spermatozoid production. To establish whether this species marks one LAG per year, eight individuals were kept one year in captivity. For each specimen, LAG was compared for different phalanges of the same toe clipped at start and end of captivity.Leptodactylus latransmarked one LAG per year, indicating a growth rhythm adjusted to a seasonal environment and mainly driven by genetic factors. Longevity was five years for both sexes and frogs reached sexual maturity during the first year, exhibiting a reproductive lifespan of four years. Sexual maturity was related to a minimal size of 60 mm or a body mass of around 33 g. There was no difference in either size or growth pattern between sexes. The von Bertalanffy growth model showed thatL. latransgrows fast after metamorphosis and their growth rate strongly decreases at about three years, probably due to the increased allocation of energy to reproduction. The high growth rates and early sexual maturation ofL. latranswould allow an elevated rate of population renewal.
Ultrastructure of Renal Lesions in Pigs with Acute Leptospirosis Caused by Leptospira pomona
Authors: Cheville N. F. , Huhn R. , Cutlip R. C. 
Published: August 2017

Twelve 4-day-old, pathogen-free pigs were inoculated intraperitoneally with virulent L. pomona. Two pigs each were killed 1, 2, 3, 5, 7, and 14 days after inoculation and their kidneys examined by light and electron microscopy. Three to 5 days after inoculation there was hyperemia, edema and swelling of tubular epithelium; leptospires were detected intravascularly, in interstitium and embedded within basement membranes. At day 7, leptospires were at basal surfaces of proximal tubules and in phagosomes in tubular epithelium. Perivascular aggregates of monocytes and macrophages were prominent. At day 14, interstitial cells were chiefly plasmacytes and lymphocytes. Leptospires were only on tubular epithelial cell surface microvilli. In another experiment, all pigs receiving low-virulent strains had leptospires in the renal interstitium at 7 days after inoculation but had none at 14 days. All low-virulent strains produced degenerative changes and lymphocyte-plasmacytic infiltration. These studies indicate that none of the low-virulent isolates were acceptable for use in vaccines. Failure of leptospires to remain attached to microvilli of proximal tubules in late stages of acute infection may be related to differences in virulence of various isolates.
Moral distress in Iranian pediatric nurses
Authors: Ghasemi Elham , Negarandeh Reza , Janani Leila 
Published: August 2017

Background: Moral distress is a very common experience in the nursing profession, and it is one of the main reasons for job dissatisfaction, burnout, and quitting among nurses. For instance, morally difficult situations in taking care of child patients who are severely ill may lead to moral distress for nurses. However, most of the studies about moral distress have been conducted on nurses of special wards and adult medical centers with much focus on developed countries. Subsequently, little has been researched on this topic among nurses in other nations such as Iran, and most certainly, there has been hardly any such research involving Iranian pediatric nurses. Aim/objectives: This study was conducted to evaluate moral distress among nurses in selected pediatric hospitals in Tehran, Iran. Research design: This cross-sectional study was conducted on eligible nurses who were selected through proportional stratified sampling and who completed demographic characteristics and the pediatric version of Moral Distress Scale-Revised questionnaires. Data were analyzed using descriptive statistics, t test, one-way analysis of variance, and Pearson correlation coefficient. Participants and research context: In total, 195 pediatric nurses working at three selected children’s specialized university hospitals in Tehran participated in this study. Ethical considerations: This study was evaluated and approved by the institutional review board of Tehran University of Medical Sciences. Findings: The mean and standard deviation of total score of moral distress was 106.41 ± 61.64 within a range of 10–257. Also, the difference between the mean score of moral distress of the group who had not quitted their position and those who have quit in the past was statistically significant (p = 0.043). The situation that was associated with the highest moral distress was “observing medical students performing painful procedures on patients just to gain some skill.” Total score of moral distress was significantly higher among male nurses (p = 0.014), while nurses with a master’s degree experienced just a higher intensity of moral distress compared to those who had a bachelor’s degree (p = 0.006). Conclusion: Since many pediatric nurses clearly face moral distress while taking care of children, it is necessary to consider measures for preventing or decreasing situations that would lead to this distress.
Retrospective analysis of goal drug level attainment of posaconazole for invasive fungal infection prophylaxis in patients with acute myeloid leukemia pre- and post-switch to tablet formulation
Authors: Liebenstein Tyler K , Widmer Kristin M , Fallon Michael J 
Published: August 2017

Background Posaconazole is approved for invasive fungal infection prophylaxis in patients with hematologic malignancies. Posaconazole suspension is plagued by poor oral absorption and dietary requirements that are difficult for patients to meet. The delayed-release tablet formulation of posaconazole may be taken without regards to meals and has significantly better oral absorption than posaconazole suspension. Objectives We sought to determine if a switch to posaconazole tablets improved steady-state drug level attainment for invasive fungal infection prophylaxis in patients with acute myeloid leukemia. Methods All adult inpatients with acute myeloid leukemia undergoing chemotherapy, who received posaconazole for invasive fungal infection prophylaxis between 2012 and 2015, were included. The primary outcome was proportion of patients with first posaconazole level greater than 700 ng/mL. Secondary outcomes included proportion of patients with first posaconazole level greater than 1000 ng/mL, invasive fungal infection within 100 days, and adverse drug events. Results Forty patients received posaconazole tablets and 34 patients received suspension. Posaconazole levels were significantly higher at first measurement in patients receiving tablet than suspension (1296 ng/mL vs. 788 ng/mL, p < 0.01). Thirty-seven patients receiving tablets had a serum drug level greater than 700 ng/mL on first measurement versus 18 receiving suspension (p < 0.01). Patients receiving tablets were also more likely to have a serum drug level over 1000 ng/mL on first measurement (26 vs. 11, p < 0.01). Rates of invasive fungal infection and adverse events were not statistically different. Conclusions Patients receiving posaconazole tablets attained significantly higher serum drug levels than those receiving suspension.
Streamlined EDSS for use in multiple sclerosis clinical practice: Development and cross-sectional comparison to EDSS
Authors: Baldassari Laura E , Salter Amber R , Longbrake Erin E , Cross Anne H , Naismith Robert T 
Published: August 2017

Background: The Expanded Disability Status Scale (EDSS) is the standard measure of disability in multiple sclerosis clinical trials. The EDSS has limited application in the clinical setting due to required completion time and scoring complexity. Systematically recording an objective, simplified, less time-intensive, and neurologist-derived disability score would be beneficial for patient care. Objective: To develop and validate a streamlined version of the Expanded Disability Status Scale (sEDSS) for clinical monitoring. Methods: The EDSS was modified by eliminating maneuvers with no impact on function, consolidating redundancies, and simplifying scoring. This sEDSS was refined and preliminarily validated using a pilot cohort of 102 patients. Subsequently, the sEDSS was retrospectively validated using 968 patients from the CombiRx trial. We evaluated correlation and agreement between each functional system as well as the overall sEDSS and EDSS. Results: The sEDSS correlated strongly with the EDSS, both overall (Spearman’s rho = 0.93) and for each functional system (Spearman’s rho 0.65–0.97). Correlation was slightly lower for functional systems where scoring was modified for consolidation and simplification. Conclusion: The sEDSS had strong agreement and correlation with the existing EDSS and can provide a useful measure of disability in clinical practice.
Drug-Eluting Biopsy Needle as a Novel Strategy for Antimicrobial Prophylaxis in Transrectal Prostate Biopsy
Authors: Sieczkowski Marcin , Gibas Artur , Wasik Andrzej , Kot-Wasik Agata , Piechowicz Lidia , Namieśnik Jacek , Matuszewski Marcin 
Published: August 2017

Objectives: To preclinically evaluate drug-eluting biopsy needles (patent pending WO2016118026) as a new potential way of antimicrobial prophylaxis for transrectal prostate biopsy. Methods: Twenty steel biopsy needles have been coated with polyvinyl alcohol, ciprofloxacin, and amikacin. Modified biopsy needles have been randomly divided into 3 groups (1:2:1 ratio). Needles from group I were immersed for 30 minutes in dedicated test tubes containing saline. Needles from group II were immersed (one by one) for 5 seconds in a set of 12 test tubes containing saline. Then, each solution was analyzed using high-performance liquid chromatography. The results were compared with the susceptibility break points for Escherichia coli. Group III was incubated with E coli strains on Mueller-Hinton plate and then the bacterial inhibition zones surrounding needles were measured. Results: The average concentration of antibiotics eluted from needles (group I) was 361.98 ± 15.36 µg/mL for amikacin and 63.87 ± 5.95 µg/mL for ciprofloxacin. The chromatographic analysis revealed the gradual release of both antibiotics from needles (group II). The concentration of amikacin released from needles exceeded the break-point value from first to ninth immersion. Ciprofloxacin concentration was higher than break-point value in all immersions. The average bacterial inhibition zone minor axis was 42 ± 5.7 mm (group III). Conclusions: The use of drug-eluting biopsy needle could be a new potential way of antimicrobial prophylaxis for transrectal prostate biopsy. This study confirmed its biological activity as well as the gradual release of antibiotics from its surface. Confirmation of its preventive role, in terms of infectious complications after transrectal prostate biopsy, has to be evaluated in a clinical trial.
Extra-articular chondromatosis of flexor and extensor compartments of the hand: Case report and review of literature
Authors: Maccagnano Giuseppe , Notarnicola Angela , Solarino Giuseppe , Pesce Vito , Moretti Biagio 
Published: August 2017

Objectives: Tenosynovial chondromatosis is an uncommon type of chondro-dysplasia of synovial and connective tissue. We report a case of a patient with a primary right wrist extra-articular chondromatosis extending to the flexor and the extensor compartments. Methods: Until now, there has been no study describing double surgical access for such a case. Results: Due to the extension, two surgical accesses are required to completely remove the neoformation. Conclusions: At 2 years of follow-up, the good functional-clinical results and absence of recurrence confirm the validity of our surgical strategy.
Two novel direct SPIO labels and in vivo MRI detection of labeled cells after acute myocardial infarct
Authors: Korpi Riikka M , Alestalo Kirsi , Ruuska Timo , Lammentausta Eveliina , Borra Ronald , Yannopoulos Fredrik , Lehtonen Siri , Korpi Jarkko T , Lappi-Blanco Elisa , Anttila Vesa , Lehenkari Petri , Juvonen Tatu , Blanco Sequieros Roberto 
Published: August 2017

Background Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide. Cellular decay due hypoxia requires rapid and validated methods for possible therapeutic cell transplantation. Purpose To develop direct and rapid superparamagnetic iron oxide (SPIO) cell label for a large-animal model and to assess in vivo cell targeting by magnetic resonance imaging (MRI) in an experimental AMI model. Material and Methods Bone marrow mononuclear cells (BMMNCs) were labeled with SPIO particles using two novel direct labeling methods (rotating incubation method and electroporation). Labeling, iron incorporation in cells and label distribution, cellular viability, and proliferation were validated in vitro. An AMI porcine model was used to evaluate the direct labeling method (rotating incubation method) by examining targeting of labeled BMMNCs using MRI and histology. Results Labeling (1 h) did not alter either cellular differentiation potential or viability of cells in vitro. Cellular relaxation values at 9.4 T correlated with label concentration and MRI at 1.5 T showing 89 ± 4% signal reduction compared with non-labeled cells in vitro. In vivo, a high spatial correlation between MRI and histology was observed. The extent of macroscopic pathological myocardial changes (hemorrhage) correlated with altered function detected on MRI. Conclusion We demonstrated two novel direct SPIO labeling methods and demonstrated the feasibility of clinical MRI for monitoring targeting of the labeled cells in animal models of AMI.
Interleukin-6 levels predict event-free survival in pediatric AML and suggest a mechanism of chemotherapy resistance
Authors: Stevens Alexandra M. , Miller Jennifer M. , Munoz Jaime O. , Gaikwad Amos S. , Redell Michele S. 
Published: August 2017

Key PointsIL-6 levels in bone marrow predict event-free survival in pediatric AML. Exogenous IL-6 protects AML blasts from chemotherapy-induced apoptosis.
Property changes of oil shale during artificial maturation: The Irati Formation from the Paraná Basin, Brazil
Authors: Moyer James , Prasad Manika 
Published: August 2017

Acquiring elastic property information from oil shale during pyrolysis remains a difficult endeavor. We subject oil shale samples from the Irati Formation in the Paraná Basin, Brazil, to high-temperature, high-pressure hydrous and anhydrous pyrolysis while simultaneously acquiring P- and S-waveform data. We present elastic properties as a function of temperature at constant differential pressure using samples cored in three different directions relative to the bedding plane. Hydrous pyrolysis decreased total organic carbon (TOC) in samples from 25 wt% to 20 wt%, whereas anhydrous pyrolysis had no significant change in TOC. The cores experienced higher strain hysteresis (up to –0.094 residual axial strain) after hydrous pyrolysis compared to after anhydrous pyrolysis ([Formula: see text] residual axial strain). The larger residual strain was accompanied by a larger increase in shear velocity up to 35% after hydrous pyrolysis as compared to the 3% shear velocity increase after anhydrous pyrolysis. The change could be a result of compression and loss of organic content determined at an ambient temperature of 25°C. We quantified sample changes using X-ray computed tomography, scanning electron microscopy, source rock analysis, and X-ray diffraction before and after pyrolysis. Our data on elastic properties and Thomsen’s parameters during pyrolysis can be used to extract material property information useful for improving subsurface well logging and 4D seismic to produce efficiently from oil shale formations.
Deleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma
Authors: Shindo Koji , Yu Jun , Suenaga Masaya , Fesharakizadeh Shahriar , Cho Christy , Macgregor-Das Anne , Siddiqui Abdulrehman , Witmer P. Dane , Tamura Koji , Song Tae Jun , Navarro Almario Jose Alejandro , Brant Aaron , Borges Michael , Ford Madeline , Barkley Thomas , He Jin , Weiss Matthew J. , Wolfgang Christopher L. , Roberts Nicholas J. , Hruban Ralph H. , Klein Alison P. , Goggins Michael 
Published: August 2017

Purpose Deleterious germline mutations contribute to pancreatic cancer susceptibility and are well documented in families in which multiple members have had pancreatic cancer. Methods To define the prevalence of these germline mutations in patients with apparently sporadic pancreatic cancer, we sequenced 32 genes, including known pancreatic cancer susceptibility genes, in DNA prepared from normal tissue obtained from 854 patients with pancreatic ductal adenocarcinoma, 288 patients with other pancreatic and periampullary neoplasms, and 51 patients with non-neoplastic diseases who underwent pancreatic resection at Johns Hopkins Hospital between 2000 and 2015. Results Thirty-three (3.9%; 95% CI, 3.0% to 5.8%) of 854 patients with pancreatic cancer had a deleterious germline mutation, 31 (3.5%) of which affected known familial pancreatic cancer susceptibility genes: BRCA2 (12 patients), ATM (10 patients), BRCA1 (3 patients), PALB2 (2 patients), MLH1 (2 patients), CDKN2A (1 patient), and TP53 (1 patient). Patients with these germline mutations were younger than those without (mean ± SD, 60.8 ± 10.6 v 65.1 ± 10.5 years; P = .03). Deleterious germline mutations were also found in BUB1B (1) and BUB3 (1). Only three of these 33 patients had reported a family history of pancreatic cancer, and most did not have a cancer family history to suggest an inherited cancer syndrome. Five (1.7%) of 288 patients with other periampullary neoplasms also had a deleterious germline mutation. Conclusion Germline mutations in pancreatic cancer susceptibility genes are commonly identified in patients with pancreatic cancer without a significant family history of cancer. These deleterious pancreatic cancer susceptibility gene mutations, some of which are therapeutically targetable, will be missed if current family history guidelines are the main criteria used to determine the appropriateness of gene testing.
Congenital diaphragmatic hernias: from genes to mechanisms to therapies
Authors: Kardon Gabrielle , Ackerman Kate G. , McCulley David J. , Shen Yufeng , Wynn Julia , Shang Linshan , Bogenschutz Eric , Sun Xin , Chung Wendy K. 
Published: August 2017

ABSTRACT
Congenital diaphragmatic hernias (CDHs) and structural anomalies of the diaphragm are a common class of congenital birth defects that are associated with significant morbidity and mortality due to associated pulmonary hypoplasia, pulmonary hypertension and heart failure. In ∼30% of CDH patients, genomic analyses have identified a range of genetic defects, including chromosomal anomalies, copy number variants and sequence variants. The affected genes identified in CDH patients include transcription factors, such as GATA4, ZFPM2, NR2F2 and WT1, and signaling pathway components, including members of the retinoic acid pathway. Mutations in these genes affect diaphragm development and can have pleiotropic effects on pulmonary and cardiac development. New therapies, including fetal endoscopic tracheal occlusion and prenatal transplacental fetal treatments, aim to normalize lung development and pulmonary vascular tone to prevent and treat lung hypoplasia and pulmonary hypertension, respectively. Studies of the association between particular genetic mutations and clinical outcomes should allow us to better understand the origin of this birth defect and to improve our ability to predict and identify patients most likely to benefit from specialized treatment strategies.
Match Your Own Price? Self-Matching as a Retailer’s Multichannel Pricing Strategy
Authors: Kireyev Pavel , Kumar Vineet , Ofek Elie 
Published: August 2017

Multichannel retailing has created several new strategic choices for retailers. With respect to pricing, an important decision is whether to offer a “self-matching policy,” which allows a multichannel retailer to offer the lowest of its online and store prices to consumers. In practice, we observe considerable heterogeneity in self-matching policies: There are retailers who offer to self-match and retailers who explicitly state that they will not match prices across channels. Using a game-theoretic model, we investigate the strategic forces behind the adoption (or non-adoption) of self-matching across a range of competitive scenarios, including a monopolist, two competing multichannel retailers, as well as a mixed duopoly. Though self-matching can negatively impact a retailer when consumers pay the lower price, we uncover two novel mechanisms that can make self-matching profitable in a duopoly setting. Specifically, self-matching can dampen competition online and enable price discrimination in-store. Its effectiveness in these respects depends on the decision-making stage of consumers and the heterogeneity of their preference for the online versus store channels. Surprisingly, self-matching strategies can also be profitable when consumers use “smart” devices to discover online prices in stores. Our findings provide insights for managers on how and when self-matching can be an effective pricing strategy. The online appendix is available at https://doi.org/10.1287/mksc.2017.1035 .