bluuebunny/crossref_metadata_2025_split huggingface dataset:
Twenty-five years of experience with patient-reported outcome measures in soft-tissue sarcoma patients: a systematic review
Authors: Generaal Jasmijn D. , Jansen Marnix R. , van Leeuwen Goudje L. , van Ginkel Robert J. , Been Lukas B. , van Leeuwen Barbara L. 
Published: September 2024

Abstract
Purpose
As the importance of the patient’s perspective on treatment outcome is becoming increasingly clear, the availability of patient-reported outcome measures (PROMs) has grown accordingly. There remains insufficient information regarding the quality of PROMs in patients with soft-tissue sarcomas (STSs). The objectives of this systematic review were (1) to identify all PROMs used in STS patients and (2) to critically appraise the methodological quality of these PROMs.

Methods
Literature searches were performed in MEDLINE and Embase on April 22, 2024. PROMs were identified by including all studies that evaluate (an aspect of) health-related quality of life in STS patients by using a PROM. Second, studies that assessed measurement properties of the PROMs utilized in STS patients were included. Quality of PROMs was evaluated by performing a COSMIN analysis.

Results
In 59 studies, 39 PROMs were identified, with the Toronto Extremity Salvage Score (TESS) being the most frequently utilized. Three studies evaluated methodological quality of PROMs in the STS population. Measurement properties of the TESS, Quick Disability of the Arm, Shoulder and Hand (QuickDASH) and European Organization for Research and Treatment for Cancer Quality of Life Questionnaire (EORTC-QLQ-C30) were reported. None of the PROMs utilized in the STS population can be recommended for use based on the current evidence and COSMIN analysis.

Conclusion
To ensure collection of reliable outcomes, PROMs require methodological evaluation prior to utilization in the STS population. Research should prioritize on determining relevant content and subsequently selecting the most suitable PROM for assessment.
Becoming Symbolic: Some Remarks on the Judicial Rewriting of the Offence of Animal Abuse in Poland
Authors: Suska Marek 
Published: September 2024

AbstractThe discussion on symbolic legislation unveils intriguing relationships between law and politics. However, the abundance of observations often results in conceptual chaos and raises numerous problematic questions. These inquiries revolve around the scope of the concept of symbolic legislation (is it a marginal or universal phenomenon in the legal system?), as well as the circumstances determining whether a provision or legal act is classified as symbolic legislation. Of particular interest is the question of whether a provision or legal act can “become symbolic” over time. The research goal of this study is to analyse the process of “becoming symbolic” and derive conclusions that deepen the understanding of the phenomenon of symbolic legislation. This study organises the current discussion on symbolic legislation, focusing on a case study of the structure of the crime of animal abuse in the Polish Animal Protection Act. The author illustrates how certain elements of this provision “became symbolic,” demonstrating that this process is largely independent of the motives of the legislators. In conclusion, the author emphasises the importance of consistently separating the sphere of motives from the sphere of effects in the discussion on symbolic legislation. Furthermore, the author highlights the static nature of the former and the dynamic nature of the latter.
Women’s Sexual Agency, Pleasure, and Orgasm in Popular Netflix Series: A Quantitative Content Analysis of Mixed-Gender Scenes
Authors: Oschatz Tanja , Döring Nicola , Zimmermanns Christin , Klein Verena 
Published: September 2024

AbstractMedia representations of sexuality can play a relevant role in the development of gender stereotypes and sexual learning processes. In the current pre-registered study, we examined the representation of sexuality in content on Netflix, a dominant force in global mass media consumption. We coded 271 mixed-gender sexual scenes across seven highly popular Netflix series for orgasm portrayal, depiction of sexual behaviors, including clitoral stimulation, and gendered sexual scripts (i.e., initiation, control, and expression of desires). Our results revealed a nuanced picture of women’s sexual pleasure representation. Women’s orgasms were depicted less frequently than men’s, although orgasm portrayal was generally rare. Sexual behaviors were mostly limited to penile-vaginal intercourse, though cunnilingus was depicted more frequently than fellatio. Regarding gendered sexual scripts, women were portrayed as equally sexually agentic as men, initiating sexual encounters, taking control, and expressing their needs and desires. Our findings indicate that this content simultaneously reinforces and challenges gender stereotypes related to sexual experiences, highlighting the need for sexual educators to critically address the realism of mainstream media portrayals to foster a nuanced understanding of sexuality and pleasure.
Improving preparation in the emergency trauma room: the development and impact of real-time data transfer and dashboard visualization system
Authors: Schatz Anna , Osterhoff Georg , Georgi Christoph , Joeres Fabian , Neumuth Thomas , Rockstroh Max 
Published: September 2024

Abstract

Purpose
This study examines, with clinical end users, the features of a visualization system in transmitting real-time patient data from the ambulance to the emergency trauma room (ETR) to determine if the real-time data provides the basis for more informed and timely interventions in the ETR before and after patient arrival.

Methods
We conducted a qualitative in-depth interview study with 32 physicians in six German and Swiss hospitals. A visualization system was developed as prototype to display the transfer of patient data, and it serves as a basis for evaluation by the participating physicians.

Results
The prototype demonstrated the potential benefits of improving workflow within the ETR by providing critical patient information in real-time. Physicians highlighted the importance of features such as the ABCDE scheme and vital signs that directly impact patient care. Configurable and mobile versions of the prototype were suggested to meet the specific needs of each clinic or specialist, allowing for the transfer of only essential information.

Conclusion
The results highlight on the one hand the potential need for adaptable interfaces in medical communication technologies that balance efficiency with minimizing additional workload for emergency medical services and show that the use of pre-notification systems in communication between ambulance and hospital can be supportive. Further research is recommended to assess practical application and support in clinical practice, including a re-evaluation of the enhanced prototype by professionals.
A new species of Capparis (Capparaceae) from Cambodia
Authors: Fici Silvio , Peou Youleang , Lao SengHong 
Published: September 2024

Abstract

Capparis glabrata
, a new species belonging to sect. Monostichocalyx, is described from the Kampong Cham and Takeo Provinces of Cambodia. The new species is a shrub characterized by glabrous twigs, straight or slightly recurved stipular thorns, glabrous leaf blade with apex acute or rounded, serial flowers in supra-axillary rows, yellow petals, and ellipsoid, puberulous ovaries with a knob-shaped stigma. It is related to C. echinocarpa, a species occurring in Thailand and northern Laos. The affinities of the new species to related taxa are discussed and a key is provided for all species of Capparis known from Cambodia. The conservation status is provisionally assessed as vulnerable (VU).
Why Contexts Matter for Gender Equal Outcomes in Research-Based Plant Breeding: The Case of Maize in Nigeria
Authors: Yami Mastewal , Cavicchioli Martina , Cole Steven M. , Wossen Tesfamicheal , Abdoulaye Tahirou 
Published: September 2024

AbstractMaize is an important crop for food security and livelihood improvement in Nigeria and elsewhere in Africa. Maize varieties that enable farmers to increase their productivity and profitability, for example, can help them achieve these development outcomes. Contextual factors shape women’s and men’s preferences for specific maize traits and varieties, thus influencing varietal uptake and the contribution varieties make towards securing people’s livelihoods. Understanding contextual factors is paramount to pursuing gender equal outcomes within research-based maize breeding. We review literature on the demand for and access to improved maize varieties in Nigeria by using a framework that helps breeding programs become more gender-responsive and, thereby, enhance their impact via increased uptake. Findings show that attention towards the role of social norms in shaping the contexts where women and men maize farmers negotiate production-related decisions, form trait preferences, and access improved maize varieties has been limited within breeding programs, while ethnobotanical approaches are absent. To boost gender equal outcomes, maize breeding programs should identify the reasons motivating women’s and men’s varietal preferences and their different capacities to access improved varieties with the suited characteristics. To pursue this objective, gender-based Indigenous knowledge should be integrated since the first stages of varietal development.
Das geheime Leben der Nutzpflanzen – neue Einblicke mit Biosensoren
Authors: Müller-Schüssele Stefanie J. , Schwarzländer Markus , Hahn Matthias 
Published: September 2024

Abstract
A key goal of plant biotechnology is the targeted improvement of resilience to biotic and abiotic stress. Genetically encoded biosensors can contribute to understanding stress physiology of crops by providing real-time information on dynamics of metabolism and signalling across different scales. Recently, barley plants equipped with the glutathione redox sensor Grx1-roGFP2 in their cytosol provided novel insights in the specific responses of barley to abiotic and biotic stresses.
Proteinimport über die mitochondriale Innenmembran
Authors: Busch Jakob D. , Fielden Laura F. , van der Laan Martin , Wiedemann Nils 
Published: September 2024

Abstract
The majority of mitochondrial proteins are nuclear-encoded and translated in the cytosol with an amino-terminal targeting signal called a presequence. Mitochondrial presequences are able to form amphiphilic α-helices with a positively charged and a hydrophobic side. The essential presequence translocase subunit Tim17 forms a cavity exposed to the bilayer, which harbors a negatively charged patch to initiate the translocation of positively charged presequences across the inner membrane.
Ganzzellsynthese von Calcidiol mit einem Molybdän-Biokatalysator
Authors: Kosian Dennis , Boll Matthias 
Published: September 2024

Abstract
Biotransformations have many advantages over chemical syntheses. By combining highly selective enzymatic reactions with the protective environment of living cells, novel and economically feasible processes are possible. In this article, we present a novel, oxygen-independent whole-cell-based platform for the production of calcidiol, the physiologically active form of vitamin D3 in the human body. The key biocatalyst involved is a bacterial Mo-dependent hydroxylase, originally discovered in studies of anaerobic cholesterol degradation.
Die Grenzen der Bioinformatik in der Erforschung von archaeellen Viren
Authors: Gehlert Finn O. , Chibani Cynthia M. , Schmitz-Streit Ruth A. 
Published: September 2024

Abstract
Archaeal viruses were studied by bioinformatics or isolation. While the accuracy of viral genome assemblies has improved through hybrid sequencing, this improvement is not observed in the prediction of gene functions due to missing homologs in databases. Therefore, further methods like powerful genetic systems are crucial to understand these viruses. A specific example is the system for MetSV, where the virus genome was cloned to create knockout mutants to better understand gene function.
Regulatorisches Fraktal oder evolutionärer Unfall?
Authors: Sieben Christian 
Published: September 2024

Zusammenfassung
Fraktale sind faszinierende Strukturen, die sich über mehrere Größenordnungen selbst ähnlich bleiben. Dass sich Biomoleküle wie z. B. Proteine zu fraktalen Gruppen zusammenlagern, war jedoch bisher unbekannt. Eine kürzlich erschienene Arbeit stellt ein bakterielles Protein vor, das sich spontan zu fraktalen Sierpiński-Dreiecken zusammenlagert.
Geoheritage Interpretation Panels in UNESCO Global Geoparks: Recommendations and Assessment
Authors: Štrba Ľubomír , Palgutová Silvia 
Published: September 2024

AbstractAspects of geoheritage have interested the general public for centuries. Since the global growth of geotourism and geoparks, the importance of geoheritage has become more evident, especially from the perspective of the development of (geo)tourism. From the perspective of sustainability, effective geoheritage presentation via geointerpretation and geoeducation is crucial. One of the most common and effective ways of presenting specific information in the field is an interpretive panel. This paper presents an assessment of geoheritage interpretation on interpretive panels in 11 UNESCO Global Geoparks. The proposed assessment methodology consists of six categories which include 39 assessment questions in total. The results show that the strongest feature of the evaluated panels is simplicity and clarity without losing scientific meaning, while minimal or no attention is paid to features increasing visitor’s enjoyment (e.g., questions or activities) and sustainability and conservation aspects. The approach presented in this paper may contribute to discussion and research in effective geoheritage interpretation for general public, fostering sustainable geotourism development and geoheritage management, use and protection.
Rapid LA-REIMS-based metabolic fingerprinting of serum discriminates aflatoxin-exposed from non-exposed pregnant women: a prospective cohort from the Butajira Nutrition, Mental Health, and Pregnancy (BUNMAP) Study in rural Ethiopia
Authors: Tesfamariam Kokeb , Plekhova Vera , Gebreyesus Seifu H. , Lachat Carl , Alladio Eugenio , Argaw Alemayehu , Endris Bilal Shikur , Roro Meselech , De Saeger Sarah , Vanhaecke Lynn , De Boevre Marthe 
Published: September 2024

AbstractTo date, the changes in maternal metabolic response associated with prenatal aflatoxin exposure remain largely unknown. This study investigated the effects of prenatal aflatoxin exposure on the maternal serum metabolome in rural Ethiopia. A total of 309 pregnant women were enrolled prospectively, and their serum aflatoxin concentrations were measured using targeted liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS). Serum metabolic fingerprints were obtained using laser-assisted rapid evaporative ionization mass spectrometry (LA-REIMS), followed by combination of univariate and multivariate statistical modelling to evaluate changes in circulating metabolic features between aflatoxin-exposed and unexposed mothers and to select discriminatory metabolic features. The analysis revealed that 81.8% of women were exposed to aflatoxins, with a median concentration of 12.9 pg/mg albumin. The orthogonal partial least square discriminant analysis (OPLS-DA) regression model demonstrated significant disparities in the serum metabolome when comparing Ethiopian pregnant women with low vs high aflatoxin exposure. Thirty-two differentially expressed metabolic features were identified, affecting aminoacyl-tRNA biosynthesis pathway. Several discriminatory metabolites have been identified, including glutamine, tryptophan, tyrosine, carnosine, and 1-methylnicotinamide. In conclusion, our findings indicate that aflatoxin exposure during pregnancy have shown disparities in the maternal serum metabolome, primarily affecting protein synthesis. Further research is needed to identify specific metabolite biomarkers and elucidate the underlying mechanisms.
Potential response of Mexican consumers to a Ban on genetically modified Maize imports
Authors: McFadden Brandon R. , Nalley Lawton Lanier , Durand-Morat Alvaro , Yang Wei , Loethen Katie 
Published: September 2024

AbstractMexico enacted a decree to ban the sale of genetically modified (GM) maize seed and maize for human consumption. Maize is particularly important to the average diet in Mexico as it is the main feed for the primary source of protein (poultry) and the main ingredient for the primary source of calories (corn tortillas). This study aimed to assess consumer awareness of the decree, support for the decree, and sensitivity of support given possible economic outcomes related to the decree. Additionally, we estimate the premiums consumers were willing to pay (WTP) for non-GM products relative to GM products (i.e., chicken meat, eggs, and corn tortillas). Results show that 54% of the Mexicans were unaware of the ban and that 77% of those aware supported the ban. Many consumers were willing to pay premiums to cover potential price increases due to the ban; however, not all low-income consumers would pay the potential premiums. Focusing on low-income consumers is particularly important, given they will likely be affected disproportionately more by the burden of increased food prices.
Functional conductivity imaging: quantitative mapping of brain activity
Authors: Cao Jun , Ball Iain K. , Cassidy Benjamin , Rae Caroline D. 
Published: September 2024

AbstractTheory and modelling suggest that detection of neuronal activity may be feasible using phase sensitive MRI methods. Successful detection of neuronal activity both in vitro and in vivo has been described while others have reported negative results. Magnetic resonance electrical properties tomography may be a route by which signal changes can be identified. Here, we report successful and repeatable detection at 3 Tesla of human brain activation in response to visual and somatosensory stimuli using a functional version of tissue conductivity imaging (funCI). This detects activation in both white and grey matter with apparent tissue conductivity changes of 0.1 S/m (17–20%, depending on the tissue baseline conductivity measure) allowing visualization of complete system circuitry. The degree of activation scales with the degree of the stimulus (duration or contrast). The conductivity response functions show a distinct timecourse from that of traditional fMRI haemodynamic (BOLD or Blood Oxygenation Level Dependent) response functions, peaking within milliseconds of stimulus cessation and returning to baseline within 3–4 s. We demonstrate the utility of the funCI approach by showing robust activation of the lateral somatosensory circuitry on stimulation of an index finger, on stimulation of a big toe or of noxious (heat) stimulation of the face as well as activation of visual circuitry on visual stimulation in up to five different individuals. The sensitivity and repeatability of this approach provides further evidence that magnetic resonance imaging approaches can detect brain activation beyond changes in blood supply.
Agnes, Revisited: methods and principles for community-engaged research on historic flood disasters
Authors: Fitch Bethany , Stuhl Andrew 
Published: September 2024

AbstractStories—and story-tellers—can build resilience. A body of interdisciplinary research demonstrates that personal stories collected and shared in the immediate wake of a flood disaster can improve disaster preparedness and engagement in flood management. This article explores methods and principles for community story-sharing about destructive floods that are not as recent. Agnes, Revisited is a multi-disciplinary, mixed-methods study of the history of Tropical Storm Agnes (1972) in the Susquehanna River Valley (Pennsylvania, United States). “Agnes” was the costliest natural disaster in US history at the time ($3B in 1972; $91B in 2023) and the Susquehanna River Valley withstood catastrophic flooding. Working with partners on and off campus, we wrote an original play based on 48 interviews with storm survivors and archival research on state records, historical images, and historical newspapers. The play both represented a multi-vocal account of Tropical Storm Agnes and catalyzed continued story-sharing about flooding—in the past, present, and future—including an hour-long documentary on Pennsylvania public television and a book with a regional newspaper. This article details the methods we used to devise and execute the play, as well as pursue opportunities for public scholarship that arose because of the play. We highlight seven principles for community engagement that we followed across the project. In support of broader, community-level flood resilience efforts, we encourage scholars to identify anniversaries of historic flood disasters approaching in the next 3 to 5 years and design community-engaged research projects to meet them.
A Systematic Review of Anthropogenic Noise Impact on Avian Species
Authors: Engel Margret S. , Young Robert J. , Davies William J. , Waddington David , Wood Michael D. 
Published: September 2024

Abstract
Purpose of review
This study aims to investigate anthropogenic noise impact on avian species by means of a systematic review of literature.

Recent findings
Based on previous anthropogenic noise impact frameworks, it was possible to: clarify the impacts of noise on birds; optimise the existing frameworks with findings produced over 44 years; recategorise noise impacts into more appropriate categories, indicating which are the positive and negatives, as well as acute and chronic impacts caused by anthropogenic noise; provide a significant cluster model of anthropogenic noise impacts on avian species subdivided into impacts on ‘Behaviour’ and ‘Communication/Perception’ (Cluster 1) and ‘Physiology’ (Cluster 2); and show how avian hearing frequency range overlaps noise source frequency range.

Summary
This research adopted the database of Peacock et al. [1, 2] regarding avian species due to its vast coverage across taxa. A systematic literature review of 50 peer-reviewed papers about anthropogenic noise impact on birds was undertaken. A Two-Step Cluster analysis was calculated, showing the data subdivided into two clusters. Cluster 1 (76.9%) showed behavioural responses mainly composed of negative and auditory perception and communication impacts, presenting positive or negative noise impacts. Cluster 2 (23.1%) mainly showed negative impacts on physiological outcomes caused by traffic, anthropogenic, and background noise.
New Kantorovich-type Szász–Mirakjan Operators
Authors: Mahmudov Nazim I. , Kara Mustafa 
Published: September 2024

AbstractIn this paper, we present a Kantorovich-type Szász–Mirakjan operators. Initially, we establish the recurrence relationship for the moments of these operators and provide the central moments up to the fourth degree. Subsequently, we analyze the local approximation properties of these operators using Peetre’s K-function. We investigate the rate of convergence, by utilizing the ordinary modulus of continuity and Lipschitz-type maximal functions. Additionally, we prove weighted approximation theorems and Voronoskaja-type theorems specific to these new operators. Following this, we introduce bivariate extension of these operators and investigate some approximation properties. Lastly, we include several numerical illustrative examples.