bluuebunny/crossref_metadata_2025_split huggingface dataset:
IN VIVO EFFECT OF RUTA CHALEPENSIS EXTRACT ON HEPATIC CYTOCHROME 3A1 IN RATS
Authors: Martínez-Pérez Edith Fabiola , Hernández-Terán Fernando , Serrano-Gallardo Luis Benjamín 
Published: June 2017

Background: Since the time when drugs began to be used, it became evident that they could produce a therapeutic effect,
but also a clinical condition of toxicity or no effect at all on humans, despite using the same doses in different patients.
Such untoward effects were termed “drug idiosyncrasy” and also “idiosyncratic drug effects”, but the factors producing
such diverse responses were never taken into account.
Materials and Methods: Ruta chalepensis L. (fringed rue) is an herbaceous plant of the Rutaceae family used in
traditional medicine due to its properties, such as its analgesic and antipyretic effects. This study used 25 male rats divided
into five groups. Plant extract was administered to Groups 1 and 2 at doses of 100 and 30 mg/kg/day, respectively, for three
days; Group 3 was administered 100 mg/kg/day of dexamethasone (DEX), as well as 100 mg/kg/day of Ruta chalepensis
extract; Group 4 was administered 100 mg/kg/day of DEX and treated as positive control; Group 5 was treated as negative
control and was administered a physiological solution. Twenty-four hours after the the last dose, the animals were
sacrificed and their livers were extracted.
Results: The aqueous extract of Ruta chalepensis, intraperitoneally administered, was able to induce cytochrome 3A1 in
doses of 30 mg/kg/day, and a greater inducing effect occurs when the plant is co-administered in doses of 100 mg/kg/day
with dexamethasone.
Conclusion: This study suggests that aqueous extract of Ruta chalepensis can induce cytochrome 3a1. This study helps
provide a better understanding of CYP3a regulation. Future in vitro work is needed to determine the compounds that
produce the cytochrome modulation.
“La Familia” HIV prevention program: A focus on disclosure and family acceptance for Latino immigrant MSM to the USA
Authors: M Melendez Rita , Zepeda Jorge , Samaniego Rafael , Chakravarty Deepalika , Alaniz Gabriela 
Published: June 2017

Objective. The objective of this study was to pilot test and evaluate a HIV prevention program that used a Freirean approach to engage Latino immigrant MSM (men who have sex with men) on issues of sexual orientation, family acceptance, stigma as well as HIV prevention and sexual risk behaviors. Materials and methods. Participants were evaluated using a survey before and after participation in the program and compared to a control group. Focus groups where participants discussed their experiences in the program as well as perceptions of the program were held and analyzed. Results. Survey results indicate that after their participation in the program, participants increased their safer sex behaviors, comfort disclosing their sexual orientation and support from friends. Conclusions. HIV prevention needs to incorporate cultural, social and structural factors.
Risk and Reward: Decommissioning and Footprint Reduction
Authors: Judah Janeen 
Published: June 2017

President's column
From 2007–2010, I was president of Chevron’s Environmental Management Company. We were responsible for managing end-of-life activities and environmental liabilities for the entire corporation. We removed platforms and pipelines in the Gulf of Mexico, remediated old industrial sites (including refineries, chemical plants, and service stations), and managed Chevron’s Superfund liabilities. Chevron spent several hundred million dollars a year on these activities, all with zero return, which made for uncomfortable discussions when it was time to present my budget.
“Decommissioning yields no return on investment or revenue and carries significant environmental and regulatory liabilities. The effective decommissioning of offshore platforms, subsea wells and related assets is one of the most important challenges facing the oil and gas industry today and in the future. Decommissioning decisions can no longer be avoided by the operators and the industry as a whole.”—IHS Markit Offshore Decommissioning Study Report
Decommissioning and abandonment. That was a Technology Focus topic in the January JPT, and I loved the featured quote: “Unlike a capital project, decommissioning is not something that you can choose to do or not to do.” Like death and taxes, decommissioning eventually comes for every project. The question is: Are we operationally and financially prepared for the inevitable?
The offshore decommissioning problem is huge and gets bigger every year as more platforms reach the end of their productive life. North Sea decommissioning is leading the way as fields developed in the 1970s and 1980s reach their end of life. Created 7 years ago, Decom North Sea (www.decomnorthsea.com) is an industry association that specifically addresses the decommissioning issues in the North Sea and works cooperatively among operators, regulators, and decommissioning contractors. The North Sea regulators, especially UK and Norway, recognize the growing liability.
Decommissioning Gulf of Mexico facilities got much more urgent following hurricanes Katrina and Rita in 2005; they swept right through the heart of the aging continental shelf fields of offshore Louisiana. Katrina and Rita destroyed more than 100 offshore platforms, many of which were “idle iron,” not in service pending decommissioning. Following those massive storms, US and state regulators stepped up monitoring of shut-in platforms and began pushing operators to decommission and remove idle iron before the next major hurricane.
Technology Update: Conductor Anchor Node Optimizes Efficiency of Riserless Deepwater Exploration Drilling
Authors: Kopperud E. , Knudsen A. , Dybvik S. J. , Hardinges F. , Mathis W. 
Published: June 2017

Technology Update
The conductor anchor node (CAN) technology was introduced as part of the architecture for Centrica’s Ivory deepwater exploration well in the Norwegian Sea to optimize efficient operations for the well’s riserless section.
The CAN (Fig. 1), developed by NeoDrill, is a large steel cylinder that is open at the bottom with an open guide pipe in its center. The device sets into the seabed, working similarly to a suction anchor, and carries and secures a well’s conductor (top-hole casing).
The CAN is set in place by a dynamically positioned (DP) installation vessel before the drilling rig arrives. The technology is designed to save rig time and expense, simplify logistics and rig operations, and expedite well startup (https://www.spe.org/en/jpt/jpt-article-detail/?art=2641).
With the CAN, seabed marker buoys and DP transponders were preinstalled by a construction vessel in June 2014. The spud location was prepared for an efficient startup when the drillship arrived in October of that year.
A pilot hole was drilled 50 m off-set from the preinstalled CAN to investigate for shallow hazards and record useful drilling parameters to determine soil strength.
The interpreted soil strength information was used for selecting the optimum conductor length for jetting it in and landing in the CAN. The conductor jetting method was chosen to optimize the dual-derrick rig operations.
All the riserless activities using the dual derricks were optimized to reduce the rig time and maximize the parallel-activities advantages.
Well Design and Challenges
The overall strategy for the well was to perform as much work as possible before rig arrival, to reduce exposure to weather and optimize operations in the riserless sections of the well.
NeoDrill was contracted for preinstalling the CAN to facilitate safe jetting operations and reduce the conductor string length, which is made possible for jetted or cemented conductors by the high axial load-bearing capacity of the CAN system.
Conductor analysis concluded that a 50-m CAN-supported conductor would suffice, compared with the 80- to 100-m length required for a conventional conductor. Conductor jetting is the quickest installation option, as it does not require cementing operations, tripping for a new drilling bottomhole assembly (BHA), and drillout.
The conductor jetting operation was performed using a special conductor running and drillout tool, the Dril-Quip Cam Activated Drill Ahead Tool (CADA tool), which allows each new section to be drilled without tripping for a new BHA.
The CAN allows the conductor to be landed safely without waiting for soil to consolidate (soak) before the CADA tool is released for drilling to resume. Thus, the risks of the conductor and wellhead housing sinking after the tool’s release are mitigated.
Optimism and Activity Rising in the Vaca Muerta
Authors: Jacobs Trent 
Published: June 2017

Optimism and Activity Rising in the Vaca Muerta
Confidence in the geologic potential of Argentina’s unconventional resource plays is higher than ever, which is turning the focus to how and when oil and gas producers there will ramp up commercial levels of production. At stake is whether the well-known Vaca Muerta formation will become a shale superpower—and the first outside of North America.
Its immense reserves, estimated to be 308 Tcf of gas and 16 billion bbl of oil, according to the US Energy Information Administration, and the work done so far to prove them has attracted commitments of billions of dollars from international majors BP, ExxonMobil, Shell, and Chevron.
But leading the pack is the domes-tic explorer and producer Yacimientos Petrolíferos Fiscales (YPF). The company’s progress may offer a reasonable expectation of what the future holds.
Operating more than 540 shale wells in the Vaca Muerta and running 44 rigs at the end of last year, YPF has been by far the most active shale operator in Argentina. Eighty of those wells are horizontals in the Loma Campana field, operated as a joint venture with Chevron.
The first were drilled and completed there in 2013, and the most recent have shown an average productivity increase of 25%, a figure based on 300 days of production data. In all, YPF drilled 56 horizontals last year, showing that it has picked up the pace compared with 2015 when 30 were drilled and the 2 years prior when a combined five were drilled.
The gas portion of the 62,300 BOED YPF is reporting in gross shale production (which includes areas outside Loma Campana) represents 22% of its total natural gas production. That will be an important piece of the pie chart to track going forward because the majority of YPF unconventional programs, and those of its competitors, have become increasingly focused on boosting Argentina’s gas supplies.
This is a shift from the initial programs that targeted the oil window and is being driven by a newly elected government that is aiming to reverse the country’s position as a net importer of gas.

EOR Project in the Vaca Muerta Shale Gives Water for Oil
New research from Argentina is trying to see if the Vaca Muerta shale formation is a viable candidate for enhanced oil recovery (EOR). The laboratory and field experiments completed so far are promising, which in itself is a notable development since there have been very few breakthroughs on this front for the shale sector.
The companies leading this work, Buenos Aires-based VYP Consultores and InLab, are using a simple huff-and-puff approach to shale EOR that involves injecting produced water back into a well for a soaking period of 30 days. During this time, with the well shut in, the formation does most of the work through imbibition; i.e., the water goes into the formation, and exchanges places with hydrocarbons.
Pseudodensity Log Generation by Use of Artificial Neural Networks
Authors: Carpenter Chris 
Published: June 2017

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 180439, “Pseudodensity-Log Generation by Use of Artificial Neural Networks,” by Wennan Long, University of Southern California; Di Chai, University of Kansas; and Fred Aminzadeh, University of Southern California, prepared for the 2016 SPE Western Regional Meeting, Anchorage, 23–26 May. The paper has not been peer reviewed.
The challenges of reservoir characterization can be overcome accurately and efficiently by the use of computer-based intelligence methods such as neural networks, fuzzy logic, and genetic algorithms. This paper will describe how one integrates a comprehensive methodology of data-mining techniques and artificial neural networks (ANNs) in reservoir-petrophysical-properties prediction and regeneration.
Introduction
ANNs—machine-learning models that provide the potential to establish multidimensional, nonlinear, and complex models—can be powerful tools with which to analyze experimental, industrial, and field data.
It is crucial to find the optimal data from one well to build the model with ANNs for pseudowell-log generation of a target well. Manual stratigraphic interpretation, though labor-intensive, is regarded as one approach. Data-mining techniques are another applicable approach, involving the automatic processing of data associated with nonlinearity by use of a statistical method to discover data patterns. One application in petrophysics is facies (or electrofacies) classification, which is widely used to divide well-log data to obtain target information. Clustering analysis, an adjunct to artificial intelligence, can determine electrofacies and categorize lithological profiles quite efficiently.
Porosity, one of the more important petrophysical properties, can be obtained from density logs. In this study, a three-step approach was produced. First, the authors apply preprocessing of the log data by use of standardization and dimension reduction [ principal-component analysis (PCA)]. Second, they apply clustering [model-based clustering (MBC)] to recognize specific patterns and interpret stratigraphic information. Finally, a similar pattern is chosen as input to generate a target pseudodensity log by use of ANNs.
Well-Log-Data Preprocessing Normalization. Well-log data are constructed in a matrix form whereby each row represents the depth record and each column is the different type of well log. Each well constructs one well-log matrix, and one field that has multiple wells constructs a big data set. The initial step in the first stage is to normalize well-log data. This normalization is necessary because different types of well-log data have different units. For instance, the spontaneous-potential log is given in millivolts, whereas the gamma ray log is given in an API unit.
Real-Time Monitoring of Piezoresistive Smart Cement To Verify Operations
Authors: Wilson Adam 
Published: June 2017

This article, written by Special Publications Editor Adam Wilson, contains highlights of paper OTC 27060, “Field Test for Real-Time Monitoring of Piezoresistive Smart Cement To Verify Cementing Operations,” by C. Vipulanandan, M. Ali, B. Basirat, A. Reddy, N. Amin, and A. Mohammed, University of Houston; S. Dighe, SPE, Baker Hughes; and H. Farzam, Cemex, prepared for the 2016 Offshore Technology Conference, Houston, 2–5 May. The paper has not been peer reviewed. Copyright 2016 Offshore Technology Conference. Reproduced by permission.
A field well was designed, built, and used to demonstrate the concept of real-time monitoring of the flow of drilling mud and smart cement and the hardening of the cement in place. A new method has been developed to measure the electrical resistivity of the materials with the two-probe method. Using the new concept, it has been proved that resistivity dominated the behavior of drilling fluid and smart cement.
Introduction
With reported failures and growing interest in environmental and economic concerns in the oil and gas industry, integrity of the cement sheath is of major importance. Oilwell cement serves many purposes in cemented oil and gas wells. Foremost among these is to form a sealing layer between the well casing and the geological formation.
In order to characterize the cement and cement concrete in various applications, electrical-resistivity measurement has been used by many researchers. Studies have also examined the piezo-resistive behavior of modified cement-based and polymer composites. One conclusion is that the change in resistivity has the potential to be used to determine the integrity of the materials.
Smart Oilwell Cement
Cement-slurry flow and stability are the major requirements in well cementing. Oil- and gas-well cements are usually made from Portland cement clinker or from blended hydraulic cements. When admixtures are used with cement, tensile and flexural properties are modified. Also, admixtures will have an effect on the rheology, corrosion resistance, shrinkage, thermal conductivity, specific heat, electrical conductivity, and absorption (heat and energy) properties of cement.
A smart cement has been developed that can sense any changes going on inside the borehole during cementing and during curing after the cementing job. The smart cement can sense the changes in the water/cement ratio, different additives, and any pressure applied to the cement sheath in terms of piezo resistivity. The failure compressive strain for the smart cement was 0.2% at peak compressive stress, and the resistivity change is on the order of several hundreds, making it more than 500 times more sensitive.
Theory and Concept
Impedance Model. Equivalent Circuit. It is important to identify the most appropriate equivalent circuit to represent the electrical properties of a material to characterize its performance with time. In this study, different possible equivalent circuits were analyzed to find an appropriate equivalent circuit to represent smart cement and drilling fluid.
Para além das ondas. Um ponto de partida sobre o significado social da variação entre ditongo nasal átono final e vogal oral no Português Brasileiro
Authors: Gomes Christina Abreu 
Published: June 2017

Este artigo apresenta o resultado de estudo sobre o significado social da variação entre ditongo nasal átono final e vogal oral, como em homem ~ homi, a partir do comportamento observado de falantes do Português Brasileiro em função da variável estilo de fala. Além disso, apresenta uma reflexão sobre as diferentes “ondas” ou abordagens do estudo do significado social da variação conforme apresentadas por Eckert (2012) para situar o ponto de partida deste estudo no conjunto de práticas analíticas para o estudo da variação desenvolvidas no âmbito da abordagem da Sociolinguística. Argumenta-se que o estudo do significado social da variação constitui um desafio interdisciplinar que deve abarcar tanto aspectos macro quanto microssociais. Especificamente em relação ao objeto de estudo, os resultados para estilo de fala indicaram que a variação apresenta estratificação estilística, característica típica de marcador linguístico.
Towards Research University through Ambidexterity Practice: A Lecturer Perspective
Authors: Kusumastuti Retno , Safitri Nurul , Rusmaningsih Prima Nurita 
Published: June 2017

The concept of ambidexterity in organization theory refers to an organization's ability to innovate in explorative manners (Duncan, 1980). Ambidexterity can be identified into structural ambidexterity and contextual ambidexterity (Tushman, O'Reilly, 1990). In small medium enterprises, for example, innovation activities take contextual form since most owners act both as entrepreneurs and business leaders (Kusumastuti, et.al., 2015), while in established corporations innovation activities generally occur in structural form. Thus research takes academic institution as its locus, within which innovation activities are mandatory for all civitas academica (academic community). The study uses mixed method for collecting data through questionnaires and in-depth interviews. It shows that university has the capacity to provide context in institutional support and remuneration system as a means stimulate lecturers and researchers to be more innovative. The scheme also provided structure at the university and faculty level as tools to coordinate and integrate research projects. The organizational learning at the individual level reflects the pattern of contextual ambidexterity process.
Application of Zone Model Predictive Control Artificial Pancreas During Extended Use of Infusion Set and Sensor: A Randomized Crossover-Controlled Home-Use Trial
Authors: Forlenza Gregory P. , Deshpande Sunil , Ly Trang T. , Howsmon Daniel P. , Cameron Faye , Baysal Nihat , Mauritzen Eric , Marcal Tatiana , Towers Lindsey , Bequette B. Wayne , Huyett Lauren M. , Pinsker Jordan E. , Gondhalekar Ravi , Doyle Francis J. , Maahs David M. , Buckingham Bruce A. , Dassau Eyal 
Published: June 2017

OBJECTIVE
As artificial pancreas (AP) becomes standard of care, consideration of extended use of insulin infusion sets (IIS) and continuous glucose monitors (CGMs) becomes vital. We conducted an outpatient randomized crossover study to test the safety and efficacy of a zone model predictive control (zone-MPC)–based AP system versus sensor augmented pump (SAP) therapy in which IIS and CGM failures were provoked via extended wear to 7 and 21 days, respectively.

RESEARCH DESIGN AND METHODS
A smartphone-based AP system was used by 19 adults (median age 23 years [IQR 10], mean 8.0 ± 1.7% HbA1c) over 2 weeks and compared with SAP therapy for 2 weeks in a crossover, unblinded outpatient study with remote monitoring in both study arms.

RESULTS
AP improved percent time 70–140 mg/dL (48.1 vs. 39.2%; P = 0.016) and time 70–180 mg/dL (71.6 vs. 65.2%; P = 0.008) and decreased median glucose (141 vs. 153 mg/dL; P = 0.036) and glycemic variability (SD 52 vs. 55 mg/dL; P = 0.044) while decreasing percent time &lt;70 mg/dL (1.3 vs. 2.7%; P = 0.001). AP also improved overnight control, as measured by mean glucose at 0600 h (140 vs. 158 mg/dL; P = 0.02). IIS failures (1.26 ± 1.44 vs. 0.78 ± 0.78 events; P = 0.13) and sensor failures (0.84 ± 0.6 vs. 1.1 ± 0.73 events; P = 0.25) were similar between AP and SAP arms. Higher percent time in closed loop was associated with better glycemic outcomes.

CONCLUSIONS
Zone-MPC significantly and safely improved glycemic control in a home-use environment despite prolonged CGM and IIS wear. This project represents the first home-use AP study attempting to provoke and detect component failure while successfully maintaining safety and effective glucose control.
Utility of Intraoperative Flexible Endoscopy in Frontal Sinus Surgery
Authors: Carniol Eric T. , Vázquez Alejandro , Patel Tapan D. , Liu James K. , Eloy Jean Anderson 
Published: June 2017

Background Surgical management of the frontal sinus can be challenging. Extensive frontal sinus pneumatization may form a far lateral or supraorbital recess that can be difficult to reach by conventional endoscopic surgical techniques, requiring extended approaches such as the Draf III (or endoscopic modified Lothrop) procedure. Rigid endoscopes may not allow visualization of these lateral limits to ensure full evacuation of the disease process. Methods Here we describe the utility of intraoperative flexible endoscopy in two patients with far lateral frontal sinus disease. Results In both cases, flexible endoscopy allowed confirmation of complete evacuation of pathologic material, thereby obviating more extensive surgical dissection. Conclusion In cases where visualization of the far lateral frontal sinus is inadequate with rigid endoscopes, flexible endoscopy can be used to determine the need for more extensive dissection.