bluuebunny/crossref_metadata_2025_split huggingface dataset:
New pharmacological strategies for augmenting extinction learning in anxiety disorders
Authors: Sartori Simone B. , Singewald Nicolas 
Published: November 2017

Abstract
Despite advances in the treatment of fear-, anxiety- and trauma-related disorders, a considerable proportion of patients shows only partial long-term therapeutic benefit with existing treatments. A promising option in improving therapy is speeding up and boosting the effect of exposure-based therapy (EBT) by pharmacological interventions. Here, we will discuss select examples of novel concepts in augmenting fear extinction, the central mechanisms of EBT. Based on accumulating knowledge from animal and human studies concerning the neurocircuitries and neurobiological mechanisms underlying successful fear extinction, diverse potential pharmacological targets have been identified to optimize the efficacy of fear extinction. We focus here on selected examples of these targets and present translational evidence for strengthening fear inhibitory learning by using L-DOPA and D-cycloserine. Furthermore, the potential of HDAC inhibitors and microRNAs (e. g. miR-144) as epigenetic targets, as well as neuropeptide S as a model substance with combined acute anxiolytic and extinction-facilitating properties are discussed. The presented mechanisms represent promising novel strategies that may be useful in the future for augmenting the efficacy and improving the acceptance of EBT in the treatment of anxiety disorders, although further work remains to be done in characterising the underlying modes of action and safety aspects.
Calculating Study of the Turbine at Last Stage Flow Field in the Small Volume Flow Condition
Authors: Jiang Tieliu , Jin Jianguo , Wang Zhanzhou , Cao Lihua , Li Bo 
Published: November 2017

Abstract
Based on basic equation and boundary layer theory of pneumodynamics, the thesis conducts numerical modeling and theoretical analysis on the last stage of turbine characteristics at a small volume flow by using FLUENT, gives an emphasized analysis on the position of first occurrence of backflow and its expansion direction and comes up with flow structure of the turbine flow field at last stage in the small volume flow condition. In connection with specific experiments, it puts forward the flow model of backflow occurring in the last stage field and the solution to the model. The flow field at last stage for a 100MW turbine in the small volume flow condition that is calculated by using the model is basically in conformity to the actual result.
Low Cost Integrated Navigation System for Unmanned Vessel
Authors: Yang Changsong , Wang Qi 
Published: November 2017

Abstract
Large errors of low-cost MEMS inertial measurement unit (MIMU) lead to huge navigation errors, even wrong navigation information. An integrated navigation system for unmanned vessel is proposed. It consists of a low-cost MIMU and Doppler velocity sonar (DVS). This paper presents an integrated navigation method, to improve the performance of navigation system. The integrated navigation system is tested using simulation and semi-physical simulation experiments, whose results show that attitude, velocity and position accuracy has improved awfully, giving exactly accurate navigation results. By means of the combination of low-cost MIMU and DVS, the proposed system is able to overcome fast drift problems of the low cost IMU.
Modeling and Analysis of 12-Pulse Inverter in Shipboard or Aircraft
Authors: Che Yanbo , Liu Guojian , Xu Jianmei , Zhao Yuancheng 
Published: November 2017

Abstract
With the development of DC distribution system within the isolated power system of a ship or an aircraft, more constant frequency loads will be supplied by inverters connected to DC main bus. In the operating mode conversion process of an isolated power system, inverters will inevitably suffer from serious disturbance and affect the stability of the system. Therefore, it is important to establish a model of the inverter that reflects its dynamic characteristics and based on which to conduct the stability analysis. This paper proposes a 12-pulse inverter model based on the generalized state space averaging (GSSA) method. This model can overcome the limitations of 12-pulse inverter state space averaging (SSA) model in transient analysis with good accuracy and fast analysis ability effectively. Three kinds of models for a 12-pulse aircraft inverter are built in MATLAB, namely GSSA model, SSA model and detail device model. The simulation results show the high accuracy of GSSA model in stability analysis. This study provides an effective analytical tool for stability analysis of 12-pulse inverter and also provides a reference for inverter modeling research of isolated power system such as in aircraft or ship.
Marine Search and Rescue of UAV in Long-Distance Security Modeling Simulation
Authors: Zheng Lei , Hu Jianbo , Xu Shukui 
Published: November 2017

Abstract
Long-distance safety of Marine search and rescue using drones can improve the searching speed. The current method is based on the long distance security classification of UAV.The degree of accuracy is low. A long-distance security modeling approach based on ArduinoMiniPro’s Marine search-and-rescue applying UAV is proposed. The method puts the fault tree analysis and relevant calculation for risk identification into use. The main factors affecting the safety of unmanned aerial vehicle (UAV) are long-distance searching and rescuing. The experimental results show that the proposed method can effectively build modeling for the long-distance safety of the Marine search and rescue UAV
Identification Algorithm of Uncertain Sonar Signals in Complex Marine Environment
Authors: Zhang Xuefeng 
Published: November 2017

Abstract
The current identification algorithm using sonar signal parameters of bandwidth, frequency, duration and pulse waveform which are easy to detect and imitation, to identify the identity of sonar signal, resulting in part of the sonar signal identity is not easy to distinguish. Therefore, an algorithm based on signal feature extraction and digital watermarking is proposed to recognize the uncertain sonar signals. The algorithm embeds the digital watermark into the detection signal from the uncertain sonar. The identity of the signal is recognized by detecting whether the received signal contains watermarks. Experimental results showed that the proposed algorithm can effectively improve the recognition performance of sonar signal source.
Demographic and Social Change in the Middle East and North Africa: Processes, Spatial Patterns, and Outcomes
Authors: Yüceşahin M. Murat , Tulga A. Yiğitalp 
Published: November 2017

AbstractThe Middle East and North Africa region has been an important player in the swift demographic transition process that happened in many parts of the developing world starting in the mid-twentieth century. This demographic change was not independent from the developmental efforts and political transformations that the region was experiencing. Social and demographic change in the Middle East and North Africa brought with them power struggles, changes in social and political structures, and confusion in all areas of social life, all of which could be seen in the region. This paper focuses on the more general aspects of the demographic and social characteristics in the countries of the Middle East and North Africa in 1950, 1980, and 2015, bearing in mind the relationship between mentalities and events, and dealing with the issue through the lens of social change, demographic change, resistance, and the struggle for political change in an international context. This study has two main approaches. First, it investigates demographic changes and spatial clustering with a qualitative (cluster analysis) approach in Middle Eastern and North Africa countries based on selected demographic indicators for the years 1950, 1980, and 2015. Then it discusses the relationship between the outcomes of these demographic changes and recent socio-political developments in the region. One of the main findings of this study is MENA countries present three different structures in different time-periods in terms of demographics and these structures are responsible for the regional social, economic, and political transformations.
Criteria System of Emergency Situations Risks Assessment in the Baltic Sea Ports
Authors: Bazaras Darius , Palšaitis Ramūnas , Petraška Artūras , Zvaigzne Andrejs 
Published: November 2017

Abstract
This paper reviews the principles of transportation risk assessment in the Baltic Sea ports and hinterland. The essential steps of assessment are the identification of primary criterions, the determining the underlying criterion groups and quantitative assessment of international environment indicators and nature, infrastructure indicators and organizational indicators on the basis of the multiple-criteria evaluation methods. Designed system of criteria creates a possibility for objective evaluation of risk management processes and allows planning objectively long-term risk management strategy in the ports according to certain economic development circumstances.
Methodology of Evaluation of the Impact of Picking Area Location on the Total Costs of Warehouse
Authors: Apsalons Raitis , Gromov Gennady 
Published: November 2017

Abstract
The picking system and the layout of the picking area are the key drivers for the evaluation of a warehouse picking cost. There are five variants for organizing the picking process of orders in a warehouse. The choice of a specific variant depends on the total cost of picking. The picking cost is evaluated within an uninterrupted picking process. It means that no stock out occurs in the time period of the picking process. The storing area and the picking area are created as two separate zones for picking quantities of the customer’s orders; the principle of division of orders is observed strictly. Referring to the locations of stock keeping units (SKU), two approaches of the layout of SKU in the picking area can be estimated. The first one is the single picking location for each single SKU, where replenishment is realized in the picking process. The second one - various picking locations for each single SKU, and the replenishment here is realized just only prior to a picking process or after it. The main benefits of the economy of the picking cost as far as these two approaches are concerned are the shortest picking route in the first case and one common replenishment option in the second case.
Restorer-of-FertilityMutations Recovered in Transposon-Active Lines of S Male-Sterile Maize
Authors: Gabay-Laughnan Susan , Settles A Mark , Hannah L Curtis , Porch Timothy G , Becraft Philip W , McCarty Donald R , Koch Karen E , Zhao Liming , Kamps Terry L , Chamusco Karen C , Chase Christine D 
Published: November 2017

AbstractMitochondria execute key pathways of central metabolism and serve as cellular sensing and signaling entities, functions that depend upon interactions between mitochondrial and nuclear genetic systems. This is exemplified in cytoplasmic male sterility type S (CMS-S) of Zea mays, where novel mitochondrial open reading frames are associated with a pollen collapse phenotype, but nuclear restorer-of-fertility (restorer) mutations rescue pollen function. To better understand these genetic interactions, we screened Activator-Dissociation (Ac-Ds), Enhancer/Suppressor-mutator (En/Spm), and Mutator (Mu) transposon-active CMS-S stocks to recover new restorer mutants. The frequency of restorer mutations increased in transposon-active stocks compared to transposon-inactive stocks, but most mutants recovered from Ac-Ds and En/Spm stocks were unstable, reverting upon backcrossing to CMS-S inbred lines. However, 10 independent restorer mutations recovered from CMS-S Mu transposon stocks were stable upon backcrossing. Many restorer mutations condition seed-lethal phenotypes that provide a convenient test for allelism. Eight such mutants recovered in this study included one pair of allelic mutations that were also allelic to the previously described rfl2-1 mutant. Targeted analysis of mitochondrial proteins by immunoblot identified two features that consistently distinguished restored CMS-S pollen from comparably staged, normal-cytoplasm, nonmutant pollen: increased abundance of nuclear-encoded alternative oxidase relative to mitochondria-encoded cytochrome oxidase and decreased abundance of mitochondria-encoded ATP synthase subunit 1 compared to nuclear-encoded ATP synthase subunit 2. CMS-S restorer mutants thus revealed a metabolic plasticity in maize pollen, and further study of these mutants will provide new insights into mitochondrial functions that are critical to pollen and seed development.
D-vitamin és kalciumpótlás az időskori csípőtáji törések megelőzésében
Authors: Salamon Antal , Toldy Erzsébet , Biró Csaba , Mátrai Ákos , Balassa Tibor , Lőcsei Zoltán 
Published: November 2017

Abstract: Vitamin D plays an important role in maintaining calcium and bone metabolism, a risk factor of osteoporosis, fall and fracture in old age. Reduction in D-vitamin levels associated with compensatory increased level of parathyroid hormone causes significant loss of bone matrix, so substitutions of vitamin D and calcium are very important. Many authors publish their recommended doses used for prevention of hip fracture during the last years. Some authors are satisfied only with vitamin D supplementation while others have better experiences with vitamin D and calcium substitution. On the other hand, some metaanalyses give contradictory results and propose further investigations. It is important to consider the patients’ eating habits and lifestyle as well as the risk of cardiovascular and other chronic diseases. Further trials should be done in different age groups in order to examine the effects of different doses of vitamin D without and with calcium to make a final decision. Orv Hetil. 2017; 158(43): 1699–1707.
La diversidad sexual y sus representaciones en la juventud
Authors: Chávez Martínez Mayra Aracely , Zapata Salazar Joel , Petrzelová Mazacová Jana , Villanueva Ibarra Gonzalo 
Published: November 2017

Objetivo: El objetivo del presente estudio fue indagar la percepción de la diversidad sexual a partir de las representaciones que, a través del discurso, los jóvenes expresan. Método: Se trabajó con un diseño no experimental, de corte transversal/transaccional de alcance descriptivo. Como instrumento se utilizó la técnica de Redes Semánticas Modificadas; trabajándose los siguientes indicadores: tamaño de la red, peso semántico, diferencia semántica cuantitativa y núcleo de la red. La muestra se integró por 250 jóvenes de ambos sexos, con edades entre los 19 y los 29 años. Se empleó un muestreo no probabilístico, cuyos criterios de inclusión fueron: la disponibilidad y el consentimiento informado. Resultados: Los resultados demuestran que los sujetos refieren construcciones cada vez menos rígidas en torno a la diversidad sexual, revelando en algunos casos discursos contradictorios en torno a ésta; por un lado, emociones negativas como el miedo y por otro, mayor apertura a la igualdad y al respeto. Conclusiones: Es necesario considerar que, a pesar de haberse observado una tendencia al cambio en las respuestas de los participantes de este estudio, se debe continuar monitoreando esta tendencia y sus implicaciones en generaciones pasadas y futuras.
Evaluation of role of laparoscopy in determining etiology of infertility
Authors: K. R. Hema , H. S. Lalitha 
Published: November 2017

Background: Although population explosion is a major problem in India, infertility appears to be a problem in 5-15% of Indian population. All these patients require evaluation. Laparoscopy plays a valuable role in the diagnosis of infertility. After thorough clinical examination and specific investigations, diagnostic laparoscopy is performed to detect patency of tubes, morphological defects in uterus, ovaries and tuboperitoineal factors. This study was conducted to assess the role of diagnostic laparoscopy in the investigation of female infertility and to evaluate the various causes of infertility like endometriosis, PCOD tubal and peritoneal factors, uterine anomalies, tuberculosis etc. by using diagnostic laparoscopy.Methods: Study was carried out in 60 infertile patients attending outpatient department of hospitals attached to Sri Siddhartha Medical College Hospital, Tumkur. Both primary and secondary infertility patients who were anxious to conceive and undergo diagnostic laparoscopy were evaluated. Those who were not willing and who were contraindicated for the procedure were excluded.Results: Diagnostic laparoscopy was performed in 72% of primary and 28% of secondary infertility patients. Majority of the patients of primary infertility were in age group 21-25 years and that of secondary were between 26-30 years. Majority of patients in both the groups had duration of 1-5 year of infertility. In our study tubal factors (50%) contributed to majority of the infertility causes. Complication rate was minimum and was comparable to other standard studies.Conclusions: Laparoscopic is the gold standard for diagnosing tubal and peritoneal disease, endometriosis and other pelvic pathology, because no other imaging technique gives the same degree of sensitivity or specificity. Hence diagnostic laparoscopy is an indispensable tool in the evaluation in the evaluation infertility.
Prevalence and associated risk factors of asymptomatic bacteriuria among antenatal women attending a health care center: one year study
Authors: Cooly Vijayalakshmi , Bandaru Sailaja , Salicheemala Bhuvaneswari , Surayapalem Sailaja 
Published: November 2017

Background: Asymptomatic bacteriuria is defined as presence of persistent and actively multiplying bacteria in urine in significant numbers, ≥105/ml but without clinical symptoms. Detection of ASB is important during pregnancy as it leads to 25% of symptomatic urinary tract infection in pregnant mothers, pyelonephritis, hypertension in pregnancy, postpartum UTI, anemia, preterm labour, low birth weight and perinatal death of the foetus. The objective of the present study is to identify the prevalence of ASB among pregnant women, epidemiological pattern, risk factors associated with it, type of pathogens and their antimicrobial susceptibility.Methods: A prospective cross-sectional study was conducted on 500 asymptomatic antenatal women who fulfilled the inclusion criteria attending the department of Obstetrics and Gynecology. Mid stream urine specimen was collected from all the cases and subjected to microscopic analysis and culture and sensitivity.Results: Our study showed the prevalence of ASB as 7.6% among antenatal women.78.8% of sterile cases and 13.6% as contaminants. 21-25 years was the common age group of ASB cases in our study. ASB was common among multiparous women, during 3rd trimester. Statistically significant association was observed with low socio-economic status, increases sexual activity and among illiterate cases. Escherichia coli (42.11%) was the most common isolate in the study. Other isolates were Klebsiella, Staphylococcus aureus, CONS, Citrobacter and Enterococcus sp. Imipenem, Meropenem exhibited 100% sensitivity for gram negative isolates and clindamycin for gram positive isolates.Conclusions: All the cases of ASB diagnosed should be treated based upon the culture and sensitivity report to prevent unnecessary prescription of antibiotics which can economically burden the patient as well pave a way in development of resistant strains. Hence, further initiatives should be undertaken to include urine culture sensitivity as a part of national screening programme to prevent maternal and foetal complications.
Nutritional status and health seeking behaviour of postmenopausal women: a cross sectional study in North India
Authors: Goyal Ankita , Mishra Neha , Dwivedi Shraddha 
Published: November 2017

Background: Menopause is the permanent cessation of menstruation resulting from the loss of follicular activity of the ovaries. It is a stage when the menstrual cycle stops for longer than 12 months and there is a drop in the levels of estrogen and progesterone, the two most important hormones in the female body (WHO, 1996). The onset of this physiological development not only marks the end of women’s reproductive function but also introduces them to a new phase of life. Natural menopause is recognized to have occurred after 12 consecutive months of amenorrhea, for which there is no other obvious pathological or physiological cause. The age at which menopause occurs varies widely ranging from late thirties to late fifties with the range for most women being between ages 48 and 55 years. This period is marked by fluctuations in reproductive hormones. Methods: The present study community based cross-sectional study to examine variations in menopausal characteristics between rural and urban women. Data on socio demographic variables, reproductive history, and menopausal symptoms were collected from postmenopausal women (rural 200; urban 200) the survey was conducted among women who had attained menopause, in rural and urban area of Allahabad. Results: Majority of the study participants were in the age group of 50-60 years and attained menopause at the age between 45-50 years. Symptoms of joint pains were reported by 57% of rural and 55% of urban women. The percentage of women seeking treatment for their problems was higher in the urban areas i.e., 71.0% as compared to 29.5% in rural area. Similarly among the urban women, majority of them 75.0% sought treatment from private clinics, and the remaining 25.0% sought treatment from government hospitals. There is a need to address their problem and establish health care centers for them. Conclusions: The study shows that postmenopausal women suffer from various physical as well as problems related to menopausal hormonal changes with varied frequencies. There is a need to address their problem and establish health care centers for them.
Diagnóstico organización y plantación estratégica en una micro empresa de agro alimentos del estado de Guanajuato.
Authors: Aguilar Gámez Ariadna Janine , González González Celestina , Caldera González Diana del Consuelo 
Published: November 2017

Las empresas familiares son el motor principal de la economí­a en nuestro paí­s, sin embargo, para prosperar deben enfrentarse a grandes retos y superar la mortalidad (KPMG, 2013). Estas empresas nacen con la finalidad de generar un patrimonio además de empleo, sin embargo necesitan fortalecerse para lograr sobrevivir ya que la mayorí­a decisiones se toman de manera improvisada y no planeada.El objetivo principal de este trabajo es realizar un diagnóstico organizacional de una microempresa de agroalimentos que sirva de apoyo para detectar cuáles son sus principales áreas de oportunidad y lograr su fortalecimiento a través de la formulación de un plan estratégico.El alcance de la investigación es descriptivo y los instrumentos que se utilizaron para realizar el estudio fueron dos entrevistas semiestructuradas y el llenado de una plantilla de planeación estratégica que sirviera para alinear los propósitos y las estrategias de la organización. Como resultado se propone toda una planeación nueva que contiene misión, visión, objetivos, estrategias y un exhaustivo análisis FODA; y entre las recomendaciones generales que se realizan se encuentran la estandarización de Procesos Normalizados de Operación, a través de la NOM-251-SSA1-2009.