bluuebunny/crossref_metadata_2025_split huggingface dataset:
SATB1 promotes tumor metastasis and invasiveness in oral squamous cell carcinoma
Authors: Li Y‐C , Bu L‐L , Mao L. , Ma S‐R , Liu J‐F , Yu G‐T , Deng W‐W , Zhang W‐F , Sun Z‐J 
Published: November 2016

ObjectiveOur aim is to evaluate the expression of SATB1 in human oral squamous cell carcinomas (OSCC) and its role in the invasiveness and metastasis of OSCC.Subjects and methodsA human OSCC tissue microarray was used to evaluate the expression pattern of SATB1. SATB1 mRNA knockdown was performed in human OSCC cell lines SCC25 and Cal27 to assess the function of SATB1 in the invasiveness and metastasis of OSCC.ResultsSATB1 is highly expressed in human OSCC determined by immunohistochemistry, and its nuclear/cytoplasmic ratio of histoscore is significantly correlated with patients’ prognosis. Reduced cell motility, invasiveness, expression of epithelial to mesenchymal transition (EMT) markers (N‐cadherin and β‐catenin), and elevated expression of epithelial markers were observed in SATB1‐knockdown cells in in vitro studies. Depletion of SATB1 also restored a cobblestone‐like morphology in TGF‐β1‐treated cells.ConclusionsThese findings suggest SATB1 may play an important role in OSCC invasiveness and metastasis.
Metastatic adenocarcinoma of the mandible
Authors: McGoldrick D.M. , Brady P. , Sleeman D. 
Published: November 2016

AbstractA 58‐year‐old gentleman presented to the Oral and Maxillofacial Surgery Department having been referred by his dentist with a non‐healing post‐extraction socket. Examination revealed an intraoral mass and an associated suspected pathological fracture of the right body of the mandible. He had a background of metastatic adenocarcinoma of the sigmoid colon. Subsequent biopsy of the mandibular mass confirmed metastatic spread to the mandible, a rare presentation. The patient was managed conservatively given his extensive co‐morbidities.
DEK oncogene is overexpressed during melanoma progression
Authors: Riveiro‐Falkenbach Erica , Ruano Yolanda , García‐Martín Rosa M. , Lora David , Cifdaloz Metehan , Acquadro Francesco , Ballestín Claudio , Ortiz‐Romero Pablo L. , Soengas María S. , Rodríguez‐Peralto José L. 
Published: November 2016

SummaryDEK is an oncoprotein involved in a variety of cellular functions, such as DNA repair, replication, and transcriptional control. DEK is preferentially expressed in actively proliferating and malignant cells, including melanoma cell lines in which DEK was previously demonstrated to play a critical role in proliferation and chemoresistance. Still, the impact of this protein in melanoma progression remains unclear. Thus, we performed a comprehensive analysis of DEK expression in different melanocytic tumors. The immunostaining results of 303 tumors demonstrated negligible DEK expression in benign lesions. Conversely, malignant lesions, particularly in metastatic cases, were largely positive for DEK expression, which was partially associated with genomic amplification. Importantly, DEK overexpression was correlated with histological features of aggressiveness in primary tumors and poor prognosis in melanoma patients. In conclusion, our study provides new insight into the involvement of DEK in melanoma progression, as well as proof of concept for its potential application as a marker and therapeutic target of melanoma.
Altered serum level of matrix metalloproteinase‐9 and its association with decision‐making in eating disorders
Authors: Matsumoto Junko , Hirano Yoshiyuki , Hashimoto Kenji , Ishima Tamaki , Kanahara Nobuhisa , Niitsu Tomihisa , Shiina Akihiro , Hashimoto Tasuku , Sato Yasunori , Yokote Koutaro , Murano Shunichi , Kimura Hiroshi , Hosoda Yutaka , Shimizu Eiji , Iyo Masaomi , Nakazato Michiko 
Published: November 2016

AimThe aims of this study were to determine whether the serum levels of precursor brain‐derived neurotrophic factor (proBDNF), mature BDNF (mBDNF), and matrix metalloproteinase‐9 (MMP‐9) are altered in patients with eating disorders (ED), including anorexia nervosa (AN) and bulimia nervosa (BN), and to explore whether those levels are associated with decision‐making abilities.MethodsNineteen women with AN, 28 women with BN, and 22 age‐matched healthy control women (HC) were enrolled in the current study. All participants had their decision‐making abilities assessed using the Iowa Gambling Task (IGT). Their eating‐related pathophysiology and depressive/anxiety symptoms were also evaluated.ResultsThe MMP‐9 level in AN was significantly lower than that in either BN or HC, but the serum levels of proBDNF and mBDNF did not differ among the three groups. Investigation of the serum levels of proBDNF and MMP‐9 in patients with ED and controls revealed a significant correlation between them. In the BN, there were positive correlations between mBDNF level and IGT performance and also between MMP‐9 level and IGT performance, but these correlations did not occur in AN. The MMP‐9 level was positively associated with the Symptom Scale, one of the subscales of the Bulimic Investigatory Test, Edinburgh, only in AN.ConclusionThese results suggest that the serum level of MMP‐9 plays a role in the pathophysiology of AN, and both the serum levels of mBDNF and MMP‐9 may be associated with decision‐making abilities in patients with BN.
Adult attachment and transportation into narrative worlds
Authors: RAIN MARINA , CILENTO ELENA , MACDONALD GEOFF , MAR RAYMOND A. 
Published: November 2016

AbstractAdult attachment affects close bonds, including bonds with fictional characters, but does it also influence the level of engagement with fictional worlds? This article aims to build on previous research on how attachment relates to narrative transportation. In Study 1, attachment anxiety, but not attachment avoidance, predicted a greater tendency to become transported into narratives, even after controlling for broader personality traits related to attachment. In Study 2, attachment anxiety again predicted a greater tendency to engage in narratives but only at high levels of attachment avoidance. In Study 3, this interaction between attachment anxiety and attachment avoidance in predicting narrative transportation was again observed when transportation was measured immediately after viewing a specific narrative.
Hyperammonemia in ornithine transcarbamylase‐deficient recipients following living donor liver transplantation from heterozygous carrier donors
Authors: Rahayatri Tri Hening , Uchida Hajime , Sasaki Kengo , Shigeta Takanobu , Hirata Yoshihiro , Kanazawa Hiroyuki , Mali Vidyadhar , Fukuda Akinari , Sakamoto Seisuke , Kasahara Mureo 
Published: November 2016

AbstractOrnithine transcarbamylase deficiency (OTCD) is a urea cycle disorder of X‐linked inheritance, affecting the detoxification of excess nitrogen and leading to hyperammonemia (hyper‐NH3). Living donor liver transplantation (LDLT) has been applied for the treatment of OTCD. This case series retrospectively reviewed two OTCD patients who experienced hyper‐NH3 following LDLT. The first case was a 5‐year‐old girl who had onset of OTCD at 2 years of age. Ornithine transcarbamylase (OTC) enzyme activity was 62% for the donor and 15% for the recipient. The patient suffered from recurrence of hyper‐NH3 within 2 months following LDLT. The second case was a 5‐year‐old girl who had onset of OTCD at 3 years of age. OTC enzyme activity was 42.6% for the donor and 9.7% for the recipient. The patient suffered hyper‐NH3 for 12 days starting on the date of surgery. Both of the patients transiently required continuous veno‐venous hemodialysis; however, they are currently doing well without intensive medical treatment. The use of asymptomatic OTCD heterozygous donors in LDLT has been accepted with careful examination. However, an OTCD heterozygous carrier donor should be avoided if there is another donor candidate, due to the potentially fatal condition of hyper‐NH3 following LDLT.
Integrating Household Risk Mitigation Behavior in Flood Risk Analysis: An Agent‐Based Model Approach
Authors: Haer Toon , Botzen W. J. Wouter , de Moel Hans , Aerts Jeroen C. J. H. 
Published: November 2016

AbstractRecent studies showed that climate change and socioeconomic trends are expected to increase flood risks in many regions. However, in these studies, human behavior is commonly assumed to be constant, which neglects interaction and feedback loops between human and environmental systems. This neglect of human adaptation leads to a misrepresentation of flood risk. This article presents an agent‐based model that incorporates human decision making in flood risk analysis. In particular, household investments in loss‐reducing measures are examined under three economic decision models: (1) expected utility theory, which is the traditional economic model of rational agents; (2) prospect theory, which takes account of bounded rationality; and (3) a prospect theory model, which accounts for changing risk perceptions and social interactions through a process of Bayesian updating. We show that neglecting human behavior in flood risk assessment studies can result in a considerable misestimation of future flood risk, which is in our case study an overestimation of a factor two. Furthermore, we show how behavior models can support flood risk analysis under different behavioral assumptions, illustrating the need to include the dynamic adaptive human behavior of, for instance, households, insurers, and governments. The method presented here provides a solid basis for exploring human behavior and the resulting flood risk with respect to low‐probability/high‐impact risks.
Grain‐size distributions on high‐energy sandy beaches and their relation to wave dissipation
Authors: Prodger Sam , Russell Paul , Davidson Mark 
Published: November 2016

AbstractGrain size and sorting represent two key parameters when characterizing sediments or modelling beach morphology and sediment transport. Traditionally, an average value for grain size or sorting is often assumed for the entire area, determined from only a few sediment samples, ignoring any spatial (or temporal) variability in sediment characteristics. This contribution uses a data set of physical surface sediment samples from 53 beach locations around the south‐west peninsula of the United Kingdom, in addition to bi‐monthly, high spatial resolution (mean 240 samples) digital grain‐size surveys from a high‐energy, oceanic, sandy beach (Perranporth, North Cornwall). Systematic spatial variations in grain size and sorting were consistently observed in the seaward direction across the intertidal zone of sandy beaches, with grain‐sizes coarsening and sorting improving by up to 51·7% and 64·3%, respectively. This variability was deterministically related to the time‐averaged, antecedent‐adjusted energy dissipated by breaking waves, with the observed maximum grain‐size and sorting values correlating with the location of peak wave energy dissipation (r2 = 0·998, P < 0·01).
Morphomechanics of dermis‐A method for non‐destructive testing of collagenous tissues
Authors: Shah R. G. , Pierce M. C. , Silver F. H. 
Published: November 2016

BackgroundCollagenous tissues store, transmit and dissipate elastic energy during mechanical deformation. In skin, mechanical energy is stored during loading and then is dissipated, which protects skin from mechanical failure. Thus, energy storage (elastic properties) and dissipation (viscous properties) are important characteristics of extracellular matrices (ECMs) that support the cyclic loading of ECMs without tissue failure.MethodsUniaxial stress‐strain measurements on decellularized human dermis have been made and compared to results of a non‐destructive technique involving optical coherence tomography (OCT) combined with vibrational analysis. In addition, Poisson's ratio has been determined for tensile deformation of decellularized dermis.ResultsThe modulus of decellularized dermis measured using standard tensile stress‐strain tests and that determined from calculations derived from natural frequency measurements give similar results. It is also observed that Poisson's ratio for dermis is between 0.38 and 0.63 after correction for changes in volume that occur during tensile deformation. These results suggest that the assumption that dermis and other ECMs deform at constant volume is incorrect and will lead to differences in the calculated modulus by conventional tensile stress‐strain measurements.ConclusionsIt is proposed that OCT in conjunction with vibrational analysis is a convenient way to non‐destructively measure the modulus of decellularized dermis, ECMs and other materials that have a positive curvature to their stress‐strain curves. Tensile deformation of dermis and possibly other ECMs is associated with an increase in Poisson's ratio consistent with a model of fluid expulsion from collagen fibrils during stretching. The value of Poisson's ratio should be considered in analyzing the mechanical properties of ECMs since at least dermis appears to be compressible during tensile deformation. Fluid expression during tensile deformation may play a role in mechanotransduction in skin in a similar manner to cartilage and bone tissue.
Thresholding methods for lesion segmentation of basal cell carcinoma in dermoscopy images
Authors: Kaur R. , LeAnder R. , Mishra N. K. , Hagerty J. R. , Kasmi R. , Stanley R. J. , Celebi M. E. , Stoecker W. V. 
Published: November 2016

PurposeAlgorithms employed for pigmented lesion segmentation perform poorly on dermoscopy images of basal cell carcinoma (BCC), the most common skin cancer. The main objective was to develop better methods for BCC segmentation.MethodsFifteen thresholding methods were implemented for BCC lesion segmentation. We propose two error metrics that better measure the type II error: Relative XOR Error and Lesion Capture Ratio.ResultsOn training/test sets of 305 and 34 BCC images, respectively, five new techniques outperform two state‐of‐the‐art methods used in segmentation of melanomas, based on the new error metrics.ConclusionThe proposed algorithms, which include solutions for image vignetting correction and border expansion to achieve dermatologist‐like borders, provide more inclusive and feature‐preserving border detection, favoring better BCC classification accuracy, in future work.
Quarantine versus pathogen‐reduced plasma‐coagulation factor content and rotational thromboelastometry coagulation
Authors: Theusinger Oliver M. , Goslings David , Studt Jan‐Dirk , Brand‐Staufer Brigitte , Seifert Burkhardt , Spahn Donat R. , Frey Beat M. 
Published: November 2016

BACKGROUNDDifferent types of fresh‐frozen plasma (FFP) exist, and the concentrations of plasma proteins vary between individuals and blood groups. Furthermore, processing may also influence the content. Quarantine‐stored plasma (qFFP) and plasma that was pathogen‐reduced using blood‐safety (Intercept) technology (piFFP) were analyzed regarding procoagulant and anticoagulant hemostasis proteins, including endogenous thrombin (thrombin‐generation) potential (ETP).MATERIALS AND METHODSThirty‐five samples of each type of FFP were analyzed using only male Blood Group O donors. FFP units were stored frozen for comparable periods of time before plasma protein content was assessed. Once the units were thawed, all tests were completed within 4 hours. The results are presented as means ± standard deviations or as median (minimum; maximum) and were compared using independent‐sample t tests (significance, p < 0.01).RESULTSSignificantly higher concentrations of adintegrin‐like and metalloprotease with thrombospondin type‐13 motifs (ADAMTS13), fibrinogen, Factor (F)V, FVIII, FXIII, protein S, protein S activity, antithrombin, microvesicle (<900 nm), and α2 antiplasmin were observed in qFFP. The variability of factors was significantly lower in piFFP. Tissue factor (TF) at 1 picomolar (pM) exhibited significantly longer lag time, a lower peak, lower ETP, and a lower velocity index in qFFP compared with piFFP. In TF at 5 pM, significant differences in lag time (longer in qFFP), velocity index (lower in qFFP), and peak (lower in qFFP) were observed. Rotational thromboelastometry revealed a significantly longer (p = 0.002) clot‐formation time with intrinsic thromboelastometry for piFFP and a significantly shorter clotting time (p = 0.004) with thromboelastometry fibrinogen testing for piFFP.CONCLUSIONPathogen reduction reduces procoagulant and anticoagulant coagulation factors as well as variability. A thrombin‐generation assay showed no reduced ETP and no supraphysiological thrombin generation. None of the FFP preparations is likely to be effective for treating fibrinogen deficiency.
Articular cartilage scores in cranial cruciate ligament‐deficient dogs with or without bucket handle tears of the medial meniscus
Authors: Kaufman Kathryn , Beale Brian S. , Thames Howard D. , Saunders W. Brian 
Published: November 2016

AbstractObjectiveTo compare articular cartilage scores in cranial cruciate ligament (CCL)‐deficient dogs with or without concurrent bucket handle tears (BHT) of the medial meniscus.Study DesignRetrospective case series.AnimalsClient‐owned dogs treated with arthroscopy and tibial plateau leveling osteotomy or extracapsular repair for complete CCL rupture (290 stifles from 264 dogs).MethodsMedical records and arthroscopic images were reviewed. Medial femoral condyle (MFC) and medial tibial plateau (MTP) cartilage was scored using the modified Outerbridge scale. Periarticular osteophytosis (PAO) and injury to the medial meniscus were recorded. Data were analyzed using Student'st‐tests, Wilcoxon rank‐sum test, and Fisher's exact test for changes in the stifle based on meniscal condition, body weight, and duration of lameness.ResultsPAO, MFC, and MTP articular cartilage scores were not significantly different in dogs with or without BHT. There were no significant differences in MFC or MTP scores when dogs were evaluated based on bodyweight and the presence or absence of a BHT. However, PAO formation was significantly increased in dogs weighing >13.6 kg and concurrent meniscal injury vs. dogs weighing <13.6 kg and concurrent meniscal injury (P < .001). Significantly more stifles with chronic lameness (40 of 89; 44.9%) had the highest PAO score of 2 reported compared to only 42 of 182 stifles (23.1%) with acute lameness (P < .001).ConclusionThe presence of a BHT of the medial meniscus was not associated with more severe arthroscopic articular cartilage lesions in the medial joint compartment at the time of surgery.
Modified technique for common carotid artery transposition in standing horses
Authors: Tapio Heidi , Argüelles David , Gracia‐Calvo Luis A. , Raekallio Marja 
Published: November 2016

AbstractObjectiveTo describe a modified technique for permanent translocation of the common carotid artery (CCA) to a subcutaneous position in standing horses.Study DesignExperimental study.AnimalsHealthy adult Standardbred and Warmblood horses (n = 8).MethodsSurgery was performed with the horses standing under sedation and with local anesthesia. A combination of previously described techniques was used modifying the approach and closure of the incision. The right CCA was approached through a linear skin incision dorsal and parallel to the jugular vein and through the brachiocephalicus and omohyoideus muscles. The artery was dissected free of its sheath and elevated to the skin incision with Penrose drains. The brachiocephalicus muscle was sutured in two layers underneath the artery leaving it in a subcutaneous position. The horses were allowed to heal for 3 weeks prior to catheterization of the artery.ResultsThe transposed CCA was successfully used for repeated catheterization in six of eight horses for a period of 10 weeks. None of the horses had intraoperative complications. Two horses developed mild peri‐incisional edema that resolved spontaneously. Right‐sided laryngeal hemiplegia was observed endoscopically in two horses postoperatively. Two horses developed complications (surgical site infection and excessive periarterial fibrosis) that compromised the patency of the CCA and precluded catheterization.ConclusionPermanent translocation of the CCA in standing horses was successful in six out of eight horses. Upper airway endoscopy postoperatively may be warranted as laryngeal hemiplegia may ensue.
COGNITIVE SCIENCE OF RELIGION AND FOLK THEISTIC BELIEF
Authors: Lim Daniel 
Published: November 2016

AbstractCognitive scientists of religion promise to lay bare the cognitive mechanisms that generate religious beliefs in human beings. Defenders of the debunking argument believe that the cognitive mechanisms studied in this field pose a threat to folk theism. A number of influential responses to the debunking argument rely on making two sets of distinctions: (1) proximate/ultimate explanations and (2) specific/general religious beliefs. I argue, however, that such responses have drawbacks and do not make room for folk theism. I suggest that a detour through the literature in the philosophy of mind regarding the problem of mental causation regarding nonreductive physicalism can provide a way for preserving folk theism without doing violence to the way cognitive science of religion is being practiced today. More specifically, I believe there is a way of responding to the debunking argument that does not require a rejection of the causal premise.
THE HYBRIDITY OF SCIENTIFIC KNOWLEDGE: A RESPONSE TO LEONARDO AMBASCIANO
Authors: von Stuckrad Kocku 
Published: November 2016

AbstractThis article responds to Leonardo Ambasciano's review of The Scientification of Religion: An Historical Study of Discursive Change, 1800–2000 by Kocku von Stuckrad. It criticizes a narrative that presents naturalism and science as the ultimate system of knowledge. Contesting this rhetoric, the article underscores the plurality and hybridity of knowledge systems, which is the main topic of the book under review.
TWO TYPES OF “EXPLAINING AWAY” ARGUMENTS IN THE COGNITIVE SCIENCE OF RELIGION
Authors: van Eyghen Hans 
Published: November 2016

AbstractThis article discusses “explaining away” arguments in the cognitive science of religion (CSR). I distinguish two rather different ways of explaining away religion, one where religion is shown to be incompatible with scientific findings (EA1) and one where supernatural entities are rendered superfluous by scientific explanations (EA2). After discussing possible objections to both varieties, I argue that the latter way offers better prospects for successfully explaining away religion but that some caveats must be made. In a second step, I spell out how CSR can be used to spell out an argument of the second kind. One argument (“Bias Explaining Away”) renders religion superfluous by claiming that it results from a cognitive bias and one (“Adaptationist Explaining Away”) does the same by claiming religion was (is) a useful evolutionary adaptation. I discuss some strengths and weaknesses of both arguments.
CONFESSIONS OF A LATE‐BLOOMING, “MISEDUCATED” PHILOSOPHER OF SCIENCE
Authors: Alexander Benjamin B. 
Published: November 2016

AbstractThis article provides a survey of Walker Percy's criticism of what Pope Benedict XVI calls “scientificity,” which entails a constriction of the dynamic interaction of faith and reason. The process can result in the diminishment of ethical considerations raised by science's impact on public policy. Beginning in the 1950s, Percy begins speculating about the negative influence of scientificity. The threat of a political regime using weapons of mass destruction is only one of several menacing developments. The desacrilization of human life from cradle to grave leads Percy to assert that modern science's impact is often radically incoherent. In The Moviegoer, Percy finds his existential and theistic voice that would enable him to advance his critique of science.