bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravesical Electro-Osmotic Administration of Mitomycin C
Authors: Di Stasi Savino M. , Verri Cristian , Celestino Francesco , De Carlo Francesco , Pagliarulo Vincenzo 
Published: October 2016

Bladder cancer is very common and most cases are diagnosed as nonmuscle invasive disease, which is characterized by its propensity to recur and progress. Intravesical therapy is used to delay recurrence and progression, while cystectomy is reserved for patients who are refractory to transurethral resection and intravesical therapy. There is an increasing interest in methods to enhance the delivery of intravesical chemotherapeutic agents to improve efficacy. In vitro and in vivo studies demonstrated that electro-osmosis of mitomycin C (MMC) is more effective in delivering this drug into the urothelium, lamina propria, and superficial muscle layers of the bladder wall than is passive transport. Higher MMC tissue concentrations might have a clinical impact in the treatment of nonmuscle invasive bladder cancer (NMIBC). In randomized trials, intravesical electro-osmotic MMC was associated with superior response rate in high-risk NMIBC cancer, compared with passive diffusion MMC transport. New strategies such as intravesical Bacillus Calmette-Guerin (BCG) combined with electro-osmotic MMC as well as intravesical pre-operative electro-osmotic MMC provided promising results in terms of higher remission rates and longer remission times. Device-assisted intravesical chemotherapy may be a useful ancillary procedure in the treatment of NMIBC. Its evaluation must be planned with respect to the technical functioning of equipment and their use for a clear purpose to avoid the financial and human costs associated with incorrect therapies.
Analysis of the light-extraction efficiency of SiC substrate-based flip-chip vertical light-emitting diodes with embedded photonic crystals
Authors: Liu Meng , Li Kang , Kong Fan-min , Zhao Jia , Zhao Shu-long , Meng Hao-tian 
Published: October 2016

Abstract
To improve the light-extraction efficiency (LEE) of flip-chip vertical light-emitting diodes (LEDs) grown on silicon carbide (SiC) substrate, embedded photonic crystals (PhCs) were alternatively introduced into the n-GaN layer of LEDs, since etching of the SiC substrate was very difficult. The finite-difference time-domain (FDTD) method was employed to investigate the combination effects of the micro-cavity and the embedded PhCs. The influences of the PhCs configurations on the LEE of LEDs were also examined to get an optimal structure. With the optimized parameters, about 20% enhancement of LEE was achieved comparing to planar SiC substrate-based flip-chip vertical LEDs. The LEE of conventional surface PhCs LEDs and double layer PhCs LEDs were also investigated for comparison. The results indicated that LEDs with carefully designed embedded PhCs could provide more LEE than surface PhCs LEDs. The structures proposed here offered scopes for the design of high-efficiency, high-power LEDs.
Impacts of second‐generation biofuel feedstock production in the central U.S. on the hydrologic cycle and global warming mitigation potential
Authors: Harding K. J. , Twine T. E. , VanLoocke A. , Bagley J. E. , Hill J. 
Published: October 2016

AbstractBiofuel feedstocks provide a renewable energy source that can reduce fossil fuel emissions; however, if produced on a large scale they can also impact local to regional water and carbon budgets. Simulation results for 2005–2014 from a regional weather model adapted to simulate the growth of two perennial grass biofuel feedstocks suggest that replacing at least half the current annual cropland with these grasses would increase water use efficiency and drive greater rainfall downwind of perturbed grid cells, but increased evapotranspiration (ET) might switch the Mississippi River basin from having a net warm‐season surplus of water (precipitation minus ET) to a net deficit. While this scenario reduces land required for biofuel feedstock production relative to current use for maize grain ethanol production, it only offsets approximately one decade of projected anthropogenic warming and increased water vapor results in greater atmospheric heat content.
A theoretical model for fluvial channel response time during time‐dependent climatic and tectonic forcing and its inverse applications
Authors: Goren Liran 
Published: October 2016

AbstractThe fluvial response time dictates the duration of fluvial channel adjustment in response to changing climatic and tectonic conditions. However, when these conditions vary continuously, the channel cannot equilibrate and the response time is not well defined. Here I develop an analytical solution to the linear stream power model of fluvial incision that predicts the channel topography as a function of time‐dependent climatic and tectonic conditions. From this solution, a general definition of the fluvial response time emerges: the duration over which the tectonic history needs to be known to evaluate channel topography. This new definition is used in linear inversion schemes for inferring climatic or tectonic histories from river long profiles. The analytic solution further reveals that high‐frequency climatic oscillations, such as Milankovitch cycles, are not expected to leave significant fingerprints on the long profiles of fluvially incised detachment‐limited rivers.
ENSO controls interannual fire activity in southeast Australia
Authors: Mariani M. , Fletcher M.‐S. , Holz A. , Nyman P. 
Published: October 2016

AbstractEl Niño–Southern Oscillation (ENSO) is the main mode controlling the variability in the ocean‐atmosphere system in the South Pacific. While the ENSO influence on rainfall regimes in the South Pacific is well documented, its role in driving spatiotemporal trends in fire activity in this region has not been rigorously investigated. This is particularly the case for the highly flammable and densely populated southeast Australian sector, where ENSO is a major control over climatic variability. Here we conduct the first region‐wide analysis of how ENSO controls fire activity in southeast Australia. We identify a significant relationship between ENSO and both fire frequency and area burnt. Critically, wavelet analyses reveal that despite substantial temporal variability in the ENSO system, ENSO exerts a persistent and significant influence on southeast Australian fire activity. Our analysis has direct application for developing robust predictive capacity for the increasingly important efforts at fire management.
Magnitude‐based discrimination of man‐made seismic events from naturally occurring earthquakes in Utah, USA
Authors: Koper Keith D. , Pechmann James C. , Burlacu Relu , Pankow Kristine L. , Stein Jared , Hale J. Mark , Roberson Paul , McCarter Michael K. 
Published: October 2016

AbstractWe investigate using the difference between local (ML) and coda/duration (MC) magnitude to discriminate man‐made seismic events from naturally occurring tectonic earthquakes in and around Utah. For 6846 well‐located earthquakes in the Utah region, we find that ML‐MC is on average 0.44 magnitude units smaller for mining‐induced seismicity (MIS) than for tectonic seismicity (TS). Our interpretation of this observation is that MIS occurs within near‐surface low‐velocity layers that act as a waveguide and preferentially increase coda duration relative to peak amplitude, while the vast majority of TS occurs beneath the near‐surface waveguide. A second data set of 3723 confirmed or probable explosions in the Utah region also has significantly lower ML‐MC values than TS, likely for the same reason as the MIS. These observations suggest that ML‐MC is useful as a depth indicator and could discriminate small explosions and mining‐induced earthquakes from deeper, naturally occurring earthquakes at local‐to‐regional distances.
Olivine settling in cosmic spherules during atmospheric deceleration: An indicator of the orbital eccentricity of interplanetary dust
Authors: Genge Matthew J. , Suttle Martin , Van Ginneken Matthias 
Published: October 2016

AbstractA new type of cosmic spherule is reported with textures suggesting settling of olivine during atmospheric deceleration. Numerical simulations of entry heating reveal that relict forsterite, which survives melting, can settle over the 1–2 s of flight at high entry angles and entry velocities up to 16 km s−1. Enhanced crystallization of phenocrysts by heterogeneous nucleation on accumulated relict forsterites is the most likely origin of the observed cumulate textures in cosmic spherules. Such textures in cosmic spherules reveal interplanetary dust with higher encounter velocity with the Earth that correspond to orbital eccentricities >0.3. The relative abundance of cumulate spherules suggests that 14% of ordinary chondrite‐related, S(IV)‐type asteroid dust over the last 800 kyr had relatively high orbital eccentricity owing to secular and planetary perturbations. The textures of cosmic spherules collected from sediments can therefore be used to trace dust orbital variations with time, which may influence terrestrial climate.
Aerosol optical depth distribution in extratropical cyclones over the Northern Hemisphere oceans
Authors: Naud Catherine M. , Posselt Derek J. , van den Heever Susan C. 
Published: October 2016

AbstractUsing Moderate Resolution Imaging Spectroradiometer and an extratropical cyclone database, the climatological distribution of aerosol optical depth (AOD) in extratropical cyclones is explored based solely on observations. Cyclone‐centered composites of aerosol optical depth are constructed for the Northern Hemisphere midlatitude ocean regions, and their seasonal variations are examined. These composites are found to be qualitatively stable when the impact of clouds and surface insolation or brightness is tested. The larger AODs occur in spring and summer and are preferentially found in the warm frontal and in the postcold frontal regions in all seasons. The fine mode aerosols dominate the cold sector AODs, but the coarse mode aerosols display large AODs in the warm sector. These differences between the aerosol modes are related to the varying source regions of the aerosols and could potentially have different impacts on cloud and precipitation within the cyclones.
Surface creep on the North Anatolian Fault at Ismetpasa, Turkey, 1944–2016
Authors: Bilham Roger , Ozener H. , Mencin D. , Dogru A. , Ergintav S. , Cakir Z. , Aytun A. , Aktug B. , Yilmaz O. , Johnson W. , Mattioli G. 
Published: October 2016

AbstractWe reevaluate the 72 year history of surface slip on the North Anatolian Fault at Ismetpasa since the Mw = 7.4 1944 Bolu/Gerede earthquake. A revised analysis of published observations suggests that days after the earthquake the fault had been offset by 3.7 m and 6 years later by an additional 0.74 m. Creep was first recognized on the fault in 1969 as a 0.13 m offset of a wall constructed in 1957 that now (2016) has been offset by 0.52 m. A carbon rod creep meter operated across the fault in the past 2 years confirms results from an invar wire creep meter operated 1982–1991 that surface slip is episodic. Months of fault inactivity are interrupted by slow slip (≤10 µm/d) or multiple creep events with cumulative amplitudes of 2–10 mm, durations of several weeks, and with slip rates briefly exceeding >2.5 mm/h. Creep events accommodate 80% of the surface slip and individually release ≈ 10−6 shear strain on the flanks of the uppermost 3–7 km of the fault. GPS and interferometric synthetic aperture radar methods yield a current fault slip rate of 7.6 ± 1 mm/yr suggesting that creep meters incompletely sample the full width of the surface shear zone. The slip rate has slowed from >10 mm/yr in 1969 to 6.1 mm/yr at present, 4.65 mm/yr of which appears to be due to steady interseismic creep driven by plate boundary stressing rates. We calculate that a further 1 m of aseismic surface slip will precede the next major earthquake on the fault assuming an ≈ 260 year main shock recurrence interval on this segment.
Properties of hail storms over China and the United States from the Tropical Rainfall Measuring Mission
Authors: Ni Xiang , Liu Chuntao , Zhang Qinghong , Cecil Daniel J. 
Published: October 2016

AbstractA 16 year record of hail reports over the south U.S. and from weather stations in China are collocated with precipitation features (PFs) derived from the Tropical Rainfall Measuring Mission (TRMM) radar and passive microwave observations. Differences in the way hail is reported in the two nations make it difficult to draw meaningful conclusions about storm frequency. But taking the two together yields a wide spectrum of hail sizes, suitable for comparing with remote sensing measurements. While U.S. hail reports are dominated by cases with hail size greater than 19 mm, hail reports in China mostly include diameters of 1–10 mm and mostly occur over the Tibetan Plateau. The fraction of PFs collocated with hail reports (hail PFs) reaches 3% in the plains of the U.S. In China, the fraction is higher in high elevation regions than low elevation regions. Hail PFs (as reported in the U.S.) show lower brightness temperatures, higher lightning flash rates, stronger maximum reflectivity, and higher echo tops than those with smaller hail, as reported in China. The average near surface maximum reflectivity of hail PFs at high elevations (≥2000 m) in China is about 5 dB smaller than those at low elevations. Larger hail is reported with PFs having stronger maximum reflectivity above 6 km, though the median of maximum reflectivity values at levels below 5 km is similar among the storms with large and small hail sizes.
Chondrules: The canonical and noncanonical views
Authors: Connolly Harold C. , Jones Rhian H. 
Published: October 2016

AbstractMillimeter‐scale rock particles called chondrules are the principal components of the most common meteorites, chondrites. Hence, chondrules were arguably the most abundant components of the early solar system at the time of planetesimal accretion. Despite their fundamental importance, the existence of chondrules would not be predicted from current observations and models of young planetary systems. There are many different models for chondrule formation, but no single model satisfies the many constraints determined from their mineralogical and chemical properties and from chondrule analog experiments. Significant recent progress has shown that several models can satisfy first‐order constraints and successfully reproduce chondrule thermal histories. However, second‐ and third‐order constraints such as chondrule size ranges, open system behavior, oxidation states, reheating, and chemical diversity have not generally been addressed. Chondrule formation models include those based on processes that are known to occur in protoplanetary disk environments, including interactions with the early active Sun, impacts and collisions between planetary bodies, and radiative heating. Other models for chondrule heating mechanisms are based on hypothetical processes that are possible but have not been observed, like shock waves, planetesimal bow shocks, and lightning. We examine the evidence for the canonical view of chondrule formation, in which chondrules were free‐floating particles in the protoplanetary disk, and the noncanonical view, in which chondrules were the by‐products of planetesimal formation. The fundamental difference between these approaches has a bearing on the importance of chondrules during planet formation and the relevance of chondrules to interpreting the evolution of protoplanetary disks and planetary systems.
Impact of biomass burning on soil microorganisms and plant metabolites: A view from molecular distributions of atmospheric hydroxy fatty acids over Mount Tai
Authors: Tyagi Poonam , Kawamura Kimitaka , Fu Pingqing , Bikkina Srinivas , Kanaya Yugo , Wang Zifa 
Published: October 2016

AbstractBiomass burning events (BBEs) in the North China Plain is one of the principal sources of airborne pollutants in China and also for the neighboring countries. To examine the impact of BBEs on soil bacteria and other higher plant metabolites, their tracer compounds, hydroxy fatty acids (FAs), were measured in the bulk particulate matter (total suspended particles (TSP)) over Mount Tai during the period of wheat residue burning in June 2006. Higher inputs of epicuticular waxes and soil microorganisms during high BBEs (H; 6–14 and 27 June) relative to low BBEs (L; 15–26 and 28 June) were characterized by increased concentrations of homologous series of α‐(C9–C32), β‐(C9–C32), and ω‐(C12–C28) hydroxy FAs in TSP samples. However, their relative abundances were not significantly different between H‐BBEs and L‐BBEs, suggesting their common source/transport pathways. We also found higher concentrations of trehalose and mannitol (tracers of soil microbes), and levoglucosan (tracer of biomass combustion) during H‐BBEs than L‐BBEs. These results are consistent with hydroxy FAs, suggesting that they are associated with biomass combustion processes of agricultural wastes as well as re‐suspension of mineral dust and plant pathogens. In addition, enhanced concentrations of endotoxin and mass loading of Gram‐negative bacteria during H‐BBEs (117 endotoxin units (EU) m−3 and 390 ng m−3, respectively) were noteworthy as compared to those in L‐BBEs (22.5 EU m−3 and 75 ng m−3, respectively). Back trajectory analysis and fire spots together with temporal variations of hydroxy FAs revealed an impact of biomass burning on emissions and atmospheric transport of bacteria and plant metabolites.
Microbial lipid signatures and substrate potential of organic matter in permafrost deposits: Implications for future greenhouse gas production
Authors: Stapel J. G. , Schirrmeister L. , Overduin P. P. , Wetterich S. , Strauss J. , Horsfield B. , Mangelsdorf K. 
Published: October 2016

AbstractA terrestrial permafrost core from Buor Khaya in northern Siberia comprising deposits of Late Pleistocene to Early Holocene age has been investigated to characterize living and past microbial communities with respect to modern and paleoclimate environmental conditions and to evaluate the potential of the organic matter (OM) for greenhouse gas generation. Microbial life markers—intact phospholipids and phospholipid fatty acids—are found throughout the entire core and indicate the presence of living microorganisms also in older permafrost deposits. Biomarkers for past microbial communities (branched and isoprenoid glycerol dialkyl glycerol tetraether as well as archaeol) reveal links between increased past microbial activity and intervals of high OM accumulation accompanied by increased OM quality presumably caused by local periods of moister and warmer environmental conditions. Concentrations of acetate as an excellent substrate for methanogenesis are used to assess the OM quality with respect to microbial degradability for greenhouse gas production. For this purpose two acetate pools are determined: the pore water acetate and OM bound acetate. Both depth profiles reveal similarities to the OM content and quality indicating a link between the amount of the stored OM and the potential to provide substrates for microbial greenhouse gas production. The data suggest that OM stored in the permafrost deposits is not much different in terms of OM quality than the fresh surface organic material. Considering the expected increase of permafrost thaw due to climate warming, this implies a potentially strong impact on greenhouse gas generation from permafrost areas in future with positive feedback on climate variation.
Human promyelocytic leukemia protein is targeted to distinct subnuclear domains in plant nuclei and colocalizes with nucleolar constituents in a SUMO‐dependent manner
Authors: Lamm Christian E. , Scherer Myriam , Reuter Nina , Amin Bushra , Stamminger Thomas , Sonnewald Uwe 
Published: October 2016

Eukaryotic nuclei are subdivided into subnuclear structures. Among the most prominent of these structures are the nucleolus and the PML nuclear bodies (PML‐NBs). PML‐NBs are spherical multiprotein aggregates of varying size localized in the interchromosomal area. PML‐NB formation is dependent on the presence of the promyelocytic leukemia protein (PML) as well as on post‐translational modification of core components by covalent attachment of the small ubiquitin‐like modifier (SUMO). So far, PML‐NBs as well as PML have been described in mammalian cells only, whereas no orthologs are known in the plant kingdom. In order to investigate conserved mechanisms in PML targeting, we expressed human PML (hPML) fused to the GFP in Nicotiana benthamiana. Using confocal laser scanning microscopy and coimmunoprecipitation followed by mass spectrometric analysis, we found the fusion protein in association with nucleolar constituents. Importantly, mutants of hPML, which are no longer SUMOylated, showed altered localizations, implying SUMO‐dependent targeting of hPML in plants as has previously been shown for mammalian cells. Interestingly, in the presence of proteasome inhibitors, hPML could also be found in the nucleolus of mammalian cells suggesting conserved targeting mechanisms of PML across kingdoms. Finally, Solanum tuberosum COP1, a proposed PML‐like protein from plants, was fused to the red fluorescent protein (RFP) and coexpressed with hPML::eGFP. Microscopic analysis confirmed the localization of COP1::RFP in nuclear speckles. However, hPML::eGFP did not colocalize with COP1::RFP. Hence, we conclude that plants do not possess specialized PML‐NBs, but that their functions may be covered by other subnuclear structures like the nucleolus.Database Proteomics data have been deposited to the ProteomeXchange Consortium with the identifier PXD004254.
Association of Beta‐Blocker Use With Less Prevalent Joint Pain and Lower Opioid Requirement in People With Osteoarthritis
Authors: Valdes Ana M. , Abhishek Abhishek , Muir Kenneth , Zhang Weiya , Maciewicz Rose A. , Doherty Michael 
Published: October 2016

ObjectiveRecent findings suggest that β‐adrenergic blockers have antinociceptive properties. The aim of this study was to compare levels of large‐joint pain between those taking adrenergic blockers and those taking other antihypertensive medications.MethodsData from the Genetics of Osteoarthritis and Lifestyle (GOAL) study, a secondary‐care cohort of osteoarthritis (OA) patients, were used. Joint pain was assessed using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scores in 873 individuals with symptomatic hip and/or knee OA and hypertension, who were taking ≥1 prescription antihypertensive medications. The association between adrenergic blocker prescription and at least moderate joint pain (WOMAC score <75) and use of prescription analgesics was examined using binary logistic regression. Analyses were adjusted for age, sex, body mass index, knee or hip OA, history of joint replacement (at other joints), anxiety, and depression.ResultsThe use of β‐adrenergic blockers was associated with lower WOMAC pain scores and with a lower prevalence of joint pain after adjustment for demographic variables and comorbidity (adjusted odds ratio [ORadj] for pain 0.68 [95% confidence interval (95% CI) 0.51, 0.92]; P < 0.011). No associations with pain were observed with use of alpha‐blockers (ORadj for pain 0.94 [95% CI 0.55, 1.58]) or with any other class of antihypertensive medications. Prescription of beta‐blockers was also associated negatively with opioid use (ORadj for opioids 0.73 [95% CI 0.54, 0.98]; P < 0.037) and with the use of prescription analgesics in general (ORadj for analgesics 0.74 [95% CI 0.56, 0.94]; P < 0.032).ConclusionThe use of beta‐blockers is associated with less joint pain and a lower use of opioids and other analgesics in individuals with symptomatic large‐joint OA. This observation needs to be confirmed by other studies.