bluuebunny/crossref_metadata_2025_split huggingface dataset:
Legal Perspective and Public Values in Family Planning Services: Analysis at the Jambi City Population Control and Family Planning Service
Authors: Armand Fadilah Salsabila 
Published: October 2024

<p><span class="s30">Based on the problems that occur in the city of Jambi, the unmet need rate is still high and does not reach the target</span><span class="s14"> </span><span class="s30">this indicates a lack or absence of public value in providing family planning services</span><span class="s14">. T</span><span class="s30">his study aims to describe, </span><span class="s30">analyze</span><span class="s30"> and explain public value in family planning services at the Jambi City Population Control and Family Planning Office.</span><span class="s14"> T</span><span class="s30">his research uses a descriptive qualitative method with a case study approach</span><span class="s14">. </span><span class="s30">The results showed that DPPKB Jambi City did not </span><span class="s30">fulfill</span><span class="s30"> one dimension of Public Value in providing Family Planning (KB) services to the community, in other words, it had not created optimal public value in providing KB services in the substantial value dimension.</span><span class="s38"> </span></p><p class="s35"><span class="s14">Keywords:</span></p><p class="s36"><span class="s30">Public Service; Public Value; Family Planning;</span></p><p><span class="s38"><br /></span></p>
Government Communication Strategy In Preventing And Reducing The Prevalence Of Stunting In Labuhanbatu Utara District
Authors: Tanjung Samsul , Sazali Hasan , Utami Tri Niswati 
Published: October 2024

<p class="TableParagraph"><em>This study aims to analyze and explain the government's communication strategy in the prevention and decline in the prevalence of stunting in North Labuhanbatu Regency. This research is a descriptive qualitative study used to observe the natural conditions of the prevalence of stunting in North Labuhanbatu. This research informant is determined through purposive techniques. This study collects data through semi-structured interviews, non-participant observations, and documentation. This research data refers to primary and secondary concepts, primary data sourced from interviews and observations, while secondary data sourced from relevant journal articles and books. This research data was analyzed through the Miles &amp; Huberman scheme which included reduction, presentation, and data conclusions. The validity of this research data is tested through the degree of trust (credibility), transfer (transferability), dependability, and confirmability. The results of this study indicate that the North Labuhanbatu government implemented a holistic and value-based communication strategy in stunting prevention efforts, by adopting the principles of Islamic communication such as Qaulan Sadidan, Qaulan Layyina, and Qaula Baligha to increase public awareness and participation. This strategy involves synergy between various parties, including local governments, health institutions, non-governmental organizations, and the private sector, with a focus on balanced nutrition education, health education, and successful narratives. Facing challenges such as lack of community understanding, coordination between weak agencies, low literacy, and the lack of participation of community leaders, this strategy emphasizes the importance of integration of stunting prevention programs with other development initiatives, optimization of communication methods, and community involvement in formulating solutions. This comprehensive and integrated approach aims to create a continuous positive impact in reducing the prevalence of stunting and building a healthier future for the people of North Labuhanbatu.</em></p><p class="TableParagraph"><em> </em></p>
Punishment Under Special Minimum Criminal Threat In the Crime of Child Abuse (Study of Decision Number 1041 K/Pid.Sus/2020)
Authors: Ahmad Rosman , Satria Hariman , Abdaud Faisal , Mafardin Mafardin 
Published: October 2024

<em><span lang="EN-US">The imposition of a penalty below the special minimum in the crime of molestation of children is a very important issue in criminal law. This crime aims to provide more effective protection to victims of immorality involving children. In some cases of child abuse, the judge handed down a verdict below the special minimum. The offense that is the focus of this study is how the judge considers sentencing under the special minimum criminal threat based on Decision Number 1041 K/Pid.Sus/2020 in the case of criminal acts of child abuse? The research method used is a type of normative legal research using 2 (two) legal approaches, namely the legislative approach and the case approach. The results of the study concluded that the </span><span lang="EN-US">Supreme Court in decision Number 1041/Pid.sus/2020 has strengthened the judex facti decision that imposes a penalty below the special minimum limit to the defendant so that the decision contradicts the provisions of Article 82 paragraph (1) of Law Number </span><span lang="EN-US">35 of 2014 concerning Amendments to Law Number 23 of 2002 concerning </span><span lang="EN-US">Child Protection is the minimum limit of 5 (five) years and a maximum of 15 (fifteen) years.</span></em>
Dynamics of Local Politics in the Digital Era Using Bibliometric and Qualitative Analysis
Authors: Hanafie Nurharsya Khaer , Amin Fatimah Hidayahni 
Published: October 2024

<em>This comprehensive analysis explores the multifaceted landscape of academic research through a systematic examination of high-impact publishers, author contributions, global academic representation, and keyword emphasis. Fig. 2 illustrates the prominence of publishers such as "Energy Research and Social Science" and "Ambio," showcasing their substantial impact in respective fields, while also recognizing the noteworthy contributions of journals with varying h-index values. The dataset spans diverse topics from energy research to social sciences, emphasizing the dynamic nature of academic contributions over different years. This study utilizes bibliometric analysis and qualitative research.This comprehensive analysis serves as a guiding framework for scholars, researchers, and policymakers, offering insights into the dynamics of high-impact publishers, the diversity of author contributions, global academic landscapes, and the nuanced aspects of local politics. The interplay of these elements shapes the rich tapestry of academic exploration, inviting continual inquiry and collaboration. In the digital era, there has been a shift in the dynamics of local politics in Makassar, increasing political awareness and public participation through social media while presenting challenges such as opinion polarization and misinformation. This study emphasizes the importance of utilizing digital technology strategies to strengthen interethnic dialogue and advance a participatory and inclusive democracy in Makassar.</em>
Male Sprague Dawley Rats with Type 2 Diabetes Mellitus and Obesity on Body Weight, Body Mass Index, and Fat Content as Affected by Alkaloid Fraction of Litsea Glutinosa Leaves (AFLG)
Authors: Muhammad Arif Husein  , Dono Indarto  , Brian Wasita  
Published: October 2024

There were 463 million people living with diabetes around the world, and it is expected to increase by 48% in 2045. Dipeptidyl Peptidase 4 (DPP4) inhibitor is asecond-line anti-diabetic drug, that frequently causes weight gain for long term treatment. Alkaloid fraction of L. glutinosa leaves (AFLG) is able to inhibit DPP4 activity in diabetic rats. Therefore, this study aimed to evaluate the effect of AFLG on body weight (BW), BMI, and fat percentage in male rats with model type 2 diabetes mellitus (T2DM) and obesity. Male Sprague Dawley rats, which weighed 200-250 g, were used in this experimental study. Twelve rats were fed with a high-fat diet for 30 days and then were intraperitoneally injected with 230 and 65 mg/kg BW nicotinamide and streptozotocin, respectively. Those rats were randomly divided into 4 groups, control (C) and three treatment (T1-T3) groups, which were orally given 20, 40, and 80 mg/kg BW/day AFLG for 28 days. Collected data were analyzed using a paired t-test, the one-way ANOVA test. Significant differences in BW in T2 and T3 (p = 0.001), Rohrer index in T2 (p = 0.001) and fat content in C (p = 0.013) were observed between before and after treatments. The average of BW, Lee, Rohrer, and TM indexes and fat content in treatment groups did not significantly differ from the C group after 28 days of treatment (p > 0.005). In conclusion, Alkaloid fraction of L. glutinosa leaves does not influence body weight, nutrition status, or fat content of male rats’ models of T2DM and obesity.
Clasificación actualizada de dentición maxilar anterior afectada por erosión dental: revisión bibliográfica
Authors: Angamarca Andrade Daniela Patricia , Sarmiento Criollo Patricio Fernando , Morales Bravo Byron Roberto 
Published: October 2024

Introducción. La erosión dental es una patología caracterizada por la pérdida irreversible de la estructura dental debido a ciertos ácidos no bacterianos. Estos ácidos pueden originarse de fuentes internas: como reflujo gastroesofágico, vómitos, entre otros. También se dan por fuentes externas como: consumo de alcohol, bebidas ácidas. Además de tener una relación con el bruxismo puede agravar la erosión dental, la atrición, abrasión, abfracción, múltiples factores combinados, comprometiendo significativamente la salud bucal. Objetivo. Considerar la clasificación actualizada de dentición maxilar anterior afectada por erosión dental. Metodología.Este estudio se llevó a cabo como una revisión investigativa descriptiva. Se realizaron búsquedas en bases de datos indexadas como PubMed, Scopus, Scielo y Google Academic, empleando palabras clave pertinentes y operadores booleanos, para la gestión de la bibliografía, se utilizó el software Zotero. Resultados. Se revisó un total de 43 estudios. Los hallazgos destacaron la eficacia de las clasificaciones Tooth Wear Index (TWI), Sistema BEWE y clasificación ECA para evaluar la erosión dental en la dentición maxilar anterior. Estas clasificaciones proporcionan guías claras y prácticas para el diagnóstico y tratamiento, basadas en la severidad y extensión del desgaste dental, mejorando significativamente la capacidad de los profesionales de la salud dental para abordar esta condición. Conclusión. Las clasificaciones Tooth Wear Index (TWI), Sistema BEWE y clasificación ECA son herramientas eficaces, para evaluar la erosión dental. Área de estudio general: Odontología. Área de estudio específica: Rehabilitación oral. Tipo de estudio: Articulo Original.
La posesión efectiva en la legislación ecuatoriana y las garantías para los herederos
Authors: Segovia Barreiro Anthony Brian , García Segarra Holger Geovannny 
Published: October 2024

Introducción. El proceso de posesión efectiva en Ecuador, crucial para la transferencia de bienes a los herederos, presenta deficiencias que afectan la equidad y justicia en la administración de sucesiones. La falta de transparencia, la inexactitud en la descripción de propiedades y la complejidad en la identificación de herederos han revelado problemas en la práctica actual. Objetivo. Analizar la efectividad de la aplicación de la posesión efectiva en la legislación ecuatoriana, centrándose en las garantías disponibles para los herederos y evaluando si éstas son adecuadas en la práctica. Esto se desglosa en la identificación de disposiciones legales relevantes y la evaluación de su aplicación por parte de notarios y autoridades competentes. Metodología. Se realizó un análisis de casos específicos en los que se han vulnerado los derechos de los herederos, utilizando una revisión de la normativa vigente, incluyendo la Constitución de la República, el Código Civil, la Ley Notarial y el Reglamento del Sistema Notarial Integral de la Función Judicial. Se examinaron las prácticas actuales para identificar deficiencias y áreas de mejora. Resultados. El estudio reveló problemas en la gestión de la posesión efectiva, como la falta de transparencia en las transacciones, la inexactitud en las descripciones de propiedades, la complejidad en la determinación de herederos y la ausencia de estándares uniformes en los procedimientos notariales. Estas deficiencias afectan negativamente la equidad y justicia en el sistema sucesorio. Conclusión. Es necesaria una reforma para abordar las deficiencias identificadas. Se propone una reforma a la Ley Notarial, que consiste en la creación de un artículo complementario. Este artículo establecerá los requisitos y procedimientos básicos notariales específicos para la realización del acta de posesión efectiva, como parte de la gestión de sucesiones y la verificación de derechos de herederos. Complementariamente, introducirá criterios para la creación de un registro centralizado de herederos, para un sistema de actualización automática del registro catastral, y la manera en que se asegure la verificación de la legitimidad de reclamaciones de herencia. Estas reformas buscan mejorar la transparencia, la equidad y la seguridad jurídica en el sistema sucesorio del país. La implementación de estas acciones podría mejorar la transparencia y equidad en la protección de los derechos de los herederos, consolidando un sistema sucesorio más justo y eficaz en Ecuador. Área de estudio general: Derecho Civil y Procedimientos Sucesorios. Área de estudio específica: Protección de los Derechos de Herederos en el Proceso de Posesión Efectiva en Ecuador. Tipo de estudio: Artículos originales.
Caracterização e avaliação de pacientes usuários de anticoagulante oral antagonista da vitamina k, em relação a complexidade da farmacoterapia
Authors: Souza Paula Larissa Loyola , Pinto Lara Patente , Freitas Yasmin Santos , Vieira Vinícius Felício Gomes , Costa Josiane Moreira da 
Published: October 2024

Introdução/delimitação da experiência: O acelerado envelhecimento populacional e o aumento da expectativa de vida, têm sido fatores contribuintes para o aumento da prevalência de doenças crônicas. Para elas, a abordagem terapêutica com anticoagulante oral Varfarina se faz relevante. Tal medicamento, no entanto, precisa ser utilizado associado a monitorização do (INR) e às intervenções terapêuticas, para melhor resultado. Objetivo: caracterizar pacientes acompanhados em um ambulatório de anticoagulação em relação ao Índice de Complexidade da Farmacoterapia (ICFT). Método: pacientes previamente selecionados, em uso de varfarina e acompanhados em um ambulatório de anticoagulação, no período de dezembro de 2018 a fevereiro de 2019. Para avaliação do ICFT, utilizou-se o instrumento Medication Regimen Complexity Index (MRCI). A complexidade foi subdividida em três níveis: baixa (<9), média (≥9 ≤16,5) e alta (>16,5) complexidade, conforme indicado pela literatura. A análise da complexidade foi realizada por dois pesquisadores de forma independente. Resultados: Um total de 93 pacientes foram incluídos no estudo, sendo a média de idade de 63 anos e a maioria do sexo feminino (68,8%). A fibrilação atrial (FA) foi a indicação da ACO mais predominante (92,5%). A média do número de medicamentos utilizados foi de 7,0. A maioria dos pacientes com farmacoterapia classificada como alta (38, 6,5%) e média complexidade (24, 80,7%) apresentou TTR inadequado. Conclusão: O presente estudo permitiu identificar que há um predomínio de pacientes com alta complexidade da farmacoterapia, o que pode indicar necessidades de cuidados adicionais em relação ao tratamento anticoagulante. Para tanto, é necessário avaliar o controle da anticoagulação satisfatório, a fim de que o serviço de saúde prestado a esse público possa ser aprimorado, de forma a gerar maior segurança e um melhor desfecho no controle da anticoagulação.
РАННЕЕ ИЗМЕРЕНИЕ КОНЦЕНТРАЦИИ ДИГОКСИНА В СЫВОРОТКЕ КРОВИ ДЛЯ ПРОГНОЗИРОВАНИЯ НЕЖЕЛАТЕЛЬНЫХ ЯВЛЕНИЙ У БОЛЬНЫХ СТАРШИХ ВОЗРАСТНЫХ ГРУПП С ХРОНИЧЕСКОЙ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТЬЮ И ФИБРИЛЛЯЦИЕЙ ПРЕДСЕРДИЙ
Authors: Яковлев А.А. , Рыжак Г.А. , Пушкин А.С. 
Published: October 2024

Исследование проводили для оценки влияния раннего измерения концентрации дигоксина в сыворотке крови (сывороточная концентрация дигоксина, СКД) на терапевтическую безопасность и эффективность применения препарата у пациентов старших возрастных групп с недавно возникшей фибрилляцией предсердий и сердечной недостаточностью. Были получены данные о том, что желудочковые аритмии de novo, атриовентрикулярные и синоатриальные блокады высокой степени были отмечены у 22 %, причем риск их развития имел прямую корреляцию с конечным значением СКД (среднее значение СКД — 0,88±0,78 нг/мл против 0,45±0,71 нг/мл; p=0,039) независимо от базовых характеристик. Эмпирические калькуляторы длительного мониторинга дигоксина коррелировали как с СКД (r=0,54...0,58; p=0,008...0,003), так и с риском развития нарушений проводимости. Повторные госпитализации по неотложным сердечно-сосудистым показаниям в течение 10 мес были связаны с более высокой конечной СКД (0,82±0,77 нг/мл у госпитализированных пациентов против 0,42±0,44 нг/мл у негоспитализированных, p=0,009), при этом не было корреляции исходной СКД с летальными исходами. Таким образом, ранний мониторинг СКД может минимизировать риск нежелательных явлений при лечении фибрилляции предсердий. Существующие эмпирические калькуляторы СКД также могут применяться в клинической практике, но их прогностическая ценность для оценки долгосрочной безопасности терапии дигоксином остается неясной и требует дальнейшего изучения.
To evaluate the effect of early measurement of serum digoxin concentration (SDC) on therapeutical safety and efficacy in patients with recent-onset atrial fibrillation and heart failure. De novo ventricular arrhythmias, high-grade AV node or sinus node blocks were noted in 22 %, this risk was positively associated with endpoint SDC (mean SDC 0,88±0,78 ng/ mL vs 0,45±0,71 ng/mL, p=0,039) irrespective of baseline characteristics. Empiric calculators for long-term digoxin monitoring correlated with both SDC (r=0,54...0,58, p=0,008...0,003) and risk of conductivity disturbances. Re-hospitalizations by urgent cardiovascular indications within 10 months were associated with higher endpoint SDC (0,82±0,77 ng/mL in hospitalized patients vs 0,42±0,44 ng/mL in non-hospitalized, p=0,009), with no association between early SDC and deaths. Early SDC monitoring may minimize the risk of adverse events in the treatment of atrial fibrillation. Existing empirical SDC calculators can also be used in clinical practice, but their predictive value for assessing the long-term safety of digoxin therapy remains unclear and requires further study.
КИШЕЧНАЯ МИКРОБИОТА И ХРОНИЧЕСКАЯ СЕРДЕЧНАЯ НЕДОСТАТОЧНОСТЬ У ЛИЦ ПОЖИЛОГО ВОЗРАСТА: ПАТОГЕНЕТИЧЕСКАЯ ВЗАИМОСВЯЗЬ И ТОЧКИ ВОЗДЕЙСТВИЯ ТЕРАПИИ
Authors: Загорулько А.А. , Дадашов М.С. , Косьмина К.О. , Бабаназарова А.Б. , Губайдулина Э.И. , Расулов М.Н. , Раевский К.П. 
Published: October 2024

Увеличение распространенности ХСН, в том числе у лиц пожилого возраста, является глобальной проблемой. Несмотря на успехи лечения, смертность данных пациентов остается высокой, из-за чего возникает потребность поиска новых механизмов развития и прогрессирования этой патологии сердечно-сосудистой системы, а также разработки инновационных ветвей терапии. Значительный интерес в последнее время направлен на изучение изменения состава микробиоты кишечника у людей с возрастом, ее роли в развитии, а также потенциального направления профилактики сердечно-сосудистых заболеваний и их осложнений. Одним из таких осложнений, особенно у лиц пожилого возраста, где прослеживается несколько линий взаимосвязи с кишечной микробиотой, является ХСН. Патогенетически влияние обусловлено хроническим системным воспалением, а также воздействием кишечных метаболитов на её течение. Цель обзора литературы — анализ и систематизация существующих научных исследований, посвященных связи между микрофлорой, ее изменениями и ХСН, а также изучение методов воздействия на звенья патогенеза, что в свою очередь способно остановить прогрессирование данного осложнения заболеваний сердечно-сосудистой системы. В обзоре представлены источники литературы, опубликованные преимущественно в период 2019–2024 гг., с использованием баз данных PubMed, ScienceDirect, eLIBRARY, включая обзорные статьи, метаанализы, клинические исследования.
The increasing prevalence of chronic heart failure (CHF) among older people is a global problem. Despite the success of treatment, the mortality rate of these patients remains high, resulting in the need to search for new mechanisms of the development and progression of cardiovascular system pathologies, as well as to develop innovative branches of therapy. Considerable recent interest has been directed towards studying changes in the composition of the intestinal microbiota in people with age, its role in development, as well as potential directions for the prevention of cardiovascular diseases and their complications. One of these complications, especially in the elderly, where several lines of relationship with the intestinal microbiota can be traced, is CHF. Pathogenetically, the effect is due to chronic systemic inflammation, as well as the effect of intestinal metabolites on its course. The objective of this literature review is to analyse and systematize existing scientific studies on the relationship between microflora, its changes and chronic heart failure, as well as to study methods of dealing with the links of pathogenesis, which in turn can stop the progression of this complication of SSS diseases. The review presents literature sources published mainly in the period 2019–2024 using PubMed, ScienceDirect, eLIBRARY databases, including review articles, meta-analyses, clinical studies.
ЭПИГЕНЕТИЧЕСКИЕ МЕХАНИЗМЫ ВЗАИМОСВЯЗИ ОСТЕОАРТРИТА СО СТАРЕНИЕМ
Authors: Мустафин Р.Н. 
Published: October 2024

Представлена гипотеза, согласно которой активация ретроэлементов при старении, вызывающая иммунные реакции в организме человека, служит пусковым механизмом развития остеоартрита. Фактором предрасположенности к этому являются ассоциированные с болезнью полиморфизмы, расположенные в интронных и межгенных областях, где локализованы мобильные элементы. В воспаленных суставах определяется изменение экспрессии множества генов, что может быть обусловлено патологической активацией ретроэлементов, влияющих на эпигенетическую дизрегуляции генома. В качестве подтверждения гипотезы представлены данные о том, что у больных остеоартритом в клетках крови выявляют активированные ретроэлементы LINE1, ERV3, HERV-K18, а в тканях суставов определяют продукты экспрессии эндогенных ретровирусов HERV-E2 и HERV-WE1, снижение активности деацетилазы гистонов Sirt6. Анализ базы данных MDTE и научной литературы позволил выявить 12 микроРНК, произошедших от LINE, 5 — от SINE, 2 — от HERV, влияющих на патогенез остеоартрита и вовлеченных в механизмы старения, что может свидетельствовать в пользу представленной гипотезы.
A hypothesis is presented according to which the activation of retroelements during aging, causing immune reactions in the human body, is a trigger for the development of osteoarthritis. Predisposition factors for this are polymorphisms associated with osteoarthritis, located in intronic and intergenic regions where transposable elements are localized. In inflamed joints, changes in the expression of many genes are determined, which may be due to pathological activation of retroelements that influence epigenetic dysregulation of the genome. To confirm the hypothesis, data are presented that in patients with osteoarthritis, activated retroelements LINE1, ERV3, HERV-K18 are detected in blood cells, expression products of endogenous retroviruses HERV-E2 and HERV-WE1 and a decrease in the activity of histone deacetylase Sirt6 are detected in joint tissues. Analysis of the MDTE database and scientific literature revealed 12 microRNAs derived from LINE, 5 derived from SINE, 2 derived from HERV, affecting the pathogenesis of osteoarthritis and involved in the mechanisms of aging, which may indicate in favor of the presented hypothesis.