bluuebunny/crossref_metadata_2025_split huggingface dataset:
Controllable Synthesis of Organic Microcrystals with Tunable Emission Color and Morphology Based on Molecular Packing Mode
Authors: Li Zhi‐Zhou , Liao Liang‐Sheng , Wang Xue‐Dong 
Published: November 2017

AbstractOrganic microcrystals are of essential importance for high fluorescence efficiency, ordered molecular packing mode, minimized defects, and smooth shapes, which are extensively applied in organic optoelectronics. The molecular packing mode significantly influences the optical/electrical properties of organic microcrystals, which makes the controllable preparation of organic microcrystals with desired molecular packing mode extremely important. In the study, yellow‐emissive α phase organic microcrystals with rectangular morphology and green‐emissive β phase perylene microcrystals with rhombic morphology are separately prepared by simply controlling the solution concentration. The distinct molecular staking modes of the H/J‐aggregate are found in these two types of perylene microcrystals, which contribute to the different emission color, morphology, and radiative decay rate. What is more interesting, the α‐doped β phase and the β‐doped α phase organic microcrystals can also be fabricated by modulating the evaporation rate from 100 to 10 µL min−1. The findings can contribute to the future development of organic optoelectronics at the microscale.
Comparative modelling and verification of Pthreads and Dthreads
Authors: Fei Yuan , Zhu Huibiao , Wu Xi , Fang Huixing , Qin Shengchao 
Published: November 2017

AbstractThe POSIX threads (Pthreads) library is a thread API for C/C++ to control parallel threads and spawn concurrent process flows. Programming in Pthreads usually suffers from undesirable deadlock, data race, and race condition problems due to the potential nondeterministic execution behaviors between parallel threads. Dthreads, as another multithreading model that re‐implements Pthreads, was proposed by Liu et al for efficient deterministic multithreading. They found out that, under specific test cases, Dthreads can effectively prevent data races. However, no comparison test has been made with Pthreads.To perform a formal comparison between Pthreads and Dthreads over deadlocks, data races, and race conditions, in this paper, we adopt CSP (communicating sequential processes) as a formal model for specifying part of API functions in Pthreads and Dthreads and illustrate the model construction using 4 classical example programs. By feeding the models into the model checker PAT (process analysis toolkit), we have verified that deadlocks and data races exist in Pthreads, but do not exist in Dthreads, for the considered programs. We have also found that neither of them can prevent race conditions. Our comparative modelling and verification of Pthreads and Dthreads show that though Dthreads cannot prevent all the deadlock situations, shown by verification results of another 2 example programs, Dthreads is better than Pthreads on eliminating data races and preventing deadlocks. Considering limited scalability of Dthreads, we have introduced a new programming model to support coarse granularity in bank transfer. Our modelling is also extended by covering the synchronization operations in Liu et al work.
Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury
Authors: Yao Erica , Lin Chuwen , Wu Qingzhe , Zhang Kuan , Song Hai , Chuang Pao-Tien 
Published: November 2017

Abstract
Production of an appropriate number of distinct cell types in precise locations during embryonic development is critical for proper tissue function. Homeostatic renewal or repair of damaged tissues in adults also requires cell expansion and transdifferentiation to replenish lost cells. However, the responses of diverse cell types to tissue injury are not fully elucidated. Moreover, the molecular mechanisms underlying transdifferentiation remain poorly understood. This knowledge is essential for harnessing the regenerative potential of individual cell types. This study investigated the fate of pulmonary neuroendocrine cells (PNECs) following lung damage to understand their plasticity and potential. PNECs are proposed to carry out diverse physiological functions in the lung and can also be the cells of origin of human small cell lung cancer. We found that Notch signaling is activated in proliferating PNECs in response to epithelial injury. Forced induction of high levels of Notch signaling in PNECs in conjunction with lung injury results in extensive proliferation and transdifferentiation of PNECs toward the fate of club cells, ciliated cells and goblet cells. Conversely, inactivating Notch signaling in PNECs abolishes their ability to switch cell fate following lung insult. We also established a connection between PNEC transdifferentiation and epigenetic modification mediated by the polycomb repressive complex 2 and inflammatory responses that involve the IL6-STAT3 pathway. These studies not only reveal a major pathway that controls PNEC fate change following lung injury but also provide tools to uncover the molecular basis of cell proliferation and fate determination in response to lung injury.
A survey of evaluation methods for personal route and destination prediction from mobility traces
Authors: Stegmann Roelant A. , Žliobaitė Indrė , Tolvanen Tuukka , Hollmén Jaakko , Read Jesse 
Published: November 2017

Personal mobility data can nowadays be easily collected by personal mobile phones and used for analytical modeling. To assist in such an analysis, a variety of computational approaches have been developed. The goal is to extract mobility patterns in order to provide traveling assistance, information, recommendations or on‐demand services. While various computational techniques are being developed, research literature on destination and route prediction lacks consistency in evaluation methods for such approaches. This study presents a review and categorization of evaluation criteria and terminology used in assessing the performance of such methods. The review is complemented by experimental analysis of selected evaluation criteria, to highlight the nuances existing between the evaluation measures. The experimental study uses previously unpublished mobility data of 15 users collected over a period of 6 months in Helsinki metropolitan area in Finland. The article is primarily intended for researchers developing approaches for personalized mobility analysis, as well as a guideline for practitioners to select criteria when assessing and selecting between computational approaches. Our main recommendation is to consider user‐specific accuracy measures in addition to averaged aggregates, as well as to take into consideration that for many users accuracy does not saturate fast and the performance keeps evolving over time. Therefore, we recommend using time‐weighted measures. WIREs Data Mining Knowl Discov 2018, 8:e1237. doi: 10.1002/widm.1237This article is categorized under:

Algorithmic Development > Spatial and Temporal Data Mining
Application Areas > Society and Culture
Application Areas > Industry Specific Applications
Multiscale memory and bioelectric error correction in the cytoplasm–cytoskeleton‐membrane system
Authors: Fields Chris , Levin Michael 
Published: November 2017

A fundamental aspect of life is the modification of anatomy, physiology, and behavior in the face of changing conditions. This is especially illustrated by the adaptive regulation of growth and form that underlies the ability of most organisms—from single cells to complex large metazoa—to develop, remodel, and regenerate to specific anatomical patterns. What is the relationship of the genome and other cellular components to the robust computations that underlie this remarkable pattern homeostasis? Here we examine the role of constraints defined at the cellular level, especially endogenous bioelectricity, in generating and propagating biological information. We review evidence that the genome is only one of several multi‐generational biological memories. Focusing on the cell membrane and cytoplasm, which is physically continuous across all of life in evolutionary timeframes, we characterize the environment as an interstitial space through which messages are passed via bioelectric and biochemical codes. We argue that biological memory is a fundamental phenomenon that cannot be understood at any one scale, and suggest that functional studies of information propagated in non‐genomic cellular structures will not only strongly impact evolutionary developmental biology, but will also have implications for regenerative medicine and synthetic bioengineering. WIREs Syst Biol Med 2018, 10:e1410. doi: 10.1002/wsbm.1410This article is categorized under:

Developmental Biology > Stem Cell Biology and Regeneration
Physiology > Physiology of Model Organisms
Models of Systems Properties and Processes > Cellular Models
Algebraic cycles and local anomalies in F-theory
Authors: Bies Martin , Mayrhofer Christoph , Weigand Timo 
Published: November 2017

AbstractWe introduce a set of identities in the cohomology ring of elliptic fibrations which are equivalent to the cancellation of gauge and mixed gauge-gravitational anomalies in F-theory compactifications to four and six dimensions. The identities consist in (co)homological relations between complex codimension-two cycles. The same set of relations, once evaluated on elliptic Calabi-Yau three-folds and four-folds, is shown to universally govern the structure of anomalies and their Green-Schwarz cancellation in six- and four-dimensional F-theory vacua, respectively. We furthermore conjecture that these relations hold not only within the cohomology ring, but even at the level of the Chow ring, i.e. as relations among codimension-two cycles modulo rational equivalence. We verify this conjecture in non-trivial examples with Abelian and non-Abelian gauge groups factors. Apart from governing the structure of local anomalies, the identities in the Chow ring relate different types of gauge backgrounds on elliptically fibred Calabi-Yau four-folds.
Moderate deviations-based importance sampling for stochastic recursive equations
Authors: Dupuis Paul , Johnson Dane 
Published: November 2017

Abstract
Subsolutions to the Hamilton–Jacobi–Bellman equation associated with a moderate deviations approximation are used to design importance sampling changes of measure for stochastic recursive equations. Analogous to what has been done for large deviations subsolution-based importance sampling, these schemes are shown to be asymptotically optimal under the moderate deviations scaling. We present various implementations and numerical results to contrast their performance, and also discuss the circumstances under which a moderate deviation scaling might be appropriate.
Uniform tail approximation of homogenous functionals of Gaussian fields
Authors: Dȩbicki Krzysztof , Hashorva Enkelejd , Liu Peng 
Published: November 2017

Abstract
Let X(t), t ∈ ℝd, be a centered Gaussian random field with continuous trajectories and set ξu(t) = X(f(u)t), t ∈ ℝd, with f some positive function. Using classical results we can establish the tail asymptotics of ℙ{Γ(ξu) > u} as u → ∞ with Γ(ξu) = supt ∈ [0, T]d ξu(t), T > 0, by requiring that f(u) tends to 0 as u → ∞ with speed controlled by the local behavior of the correlation function of X. Recent research shows that for applications, more general functionals than the supremum should be considered and the Gaussian field can depend also on some additional parameter τu ∈ K say ξu,τu(t), t ∈ ℝd. In this paper we derive uniform approximations of ℙ{Γ(ξu,τu) > u} with respect to τu, in some index set Ku as u → ∞. Our main result has important theoretical implications; two applications are already included in Dȩbicki et al. (2016), (2017). In this paper we present three additional applications. First we derive uniform upper bounds for the probability of double maxima. Second, we extend the Piterbarg–Prisyazhnyuk theorem to some large classes of homogeneous functionals of centered Gaussian fields ξu. Finally, we show the finiteness of generalized Piterbarg constants.
Application of a model of internal hydraulic jumps
Authors: Thorpe S. A. , Malarkey J. , Voet G. , Alford M. H. , Girton J. B. , Carter G. S. 
Published: November 2017

A model devised by Thorpe & Li (J. Fluid Mech., vol. 758, 2014, pp. 94–120) that predicts the conditions in which stationary turbulent hydraulic jumps can occur in the flow of a continuously stratified layer over a horizontal rigid bottom is applied to, and its results compared with, observations made at several locations in the ocean. The model identifies two positions in the Samoan Passage at which hydraulic jumps should occur and where changes in the structure of the flow are indeed observed. The model predicts the amplitude of changes and the observed mode 2 form of the transitions. The predicted dissipation of turbulent kinetic energy is also consistent with observations. One location provides a particularly well-defined example of a persistent hydraulic jump. It takes the form of a 390 m thick and 3.7 km long mixing layer with frequent density inversions separated from the seabed by some 200 m of relatively rapidly moving dense water, thus revealing the previously unknown structure of an internal hydraulic jump in the deep ocean. Predictions in the Red Sea Outflow in the Gulf of Aden are relatively uncertain. Available data, and the model predictions, do not provide strong support for the existence of hydraulic jumps. In the Mediterranean Outflow, however, both model and data indicate the presence of a hydraulic jump.
Flow structure in healthy and pathological left ventricles with natural and prosthetic mitral valves
Authors: Meschini V. , de Tullio M. D. , Querzoli G. , Verzicco R. 
Published: November 2017

In this paper, the structure and the dynamics of the flow in the left heart ventricle are studied for different pumping efficiencies and mitral valve types (natural, biological and mechanical prosthetic). The problem is investigated by direct numerical simulation of the Navier–Stokes equations, two-way coupled with a structural solver for the ventricle and mitral valve dynamics. The whole solver is preliminarily validated by comparisons with ad hoc experiments. It is found that the system works in a highly synergistic way and the left ventricular flow is heavily affected by the specific type of mitral valve, with effects that are more pronounced for ventricles with reduced pumping efficiency. When the ventricle ejection fraction (ratio of the ejected fluid volume to maximum ventricle volume over the cycle) is within the physiological range (50 %–70 %), regardless of the mitral valve geometry, the mitral jet sweeps the inner ventricle surface up to the apex, thus preventing undesired flow stagnation. In contrast, for pathological ejection fractions (⩽40 %), the flow disturbances introduced by the bileaflet mechanical valve reduce the penetration capability of the mitral jet and weaken the recirculation in the ventricular apex. Although in clinical practice the fatality rates in the five-year follow-ups for mechanical and biological mitral valve replacements are essentially the same, a breakdown of the deaths shows that the causes are very different for the two classes of prostheses and the present findings are consistent with the clinical data. This might have important clinical implications for the choice of prosthetic device in patients needing mitral valve replacement.
Unsteady propulsion by an intermittent swimming gait
Authors: Akoz Emre , Moored Keith W. 
Published: November 2017

Inviscid computational results are presented on a self-propelled swimmer modelled as a virtual body combined with a two-dimensional hydrofoil pitching intermittently about its leading edge. Lighthill (Proc. R. Soc. Lond.B, vol. 179, 1971, pp. 125–138) originally proposed that this burst-and-coast behaviour can save fish energy during swimming by taking advantage of the viscous Bone–Lighthill boundary layer thinning mechanism. Here, an additional inviscid Garrick mechanism is discovered that allows swimmers to control the ratio of their added-mass thrust-producing forces to their circulatory drag-inducing forces by decreasing their duty cycle,$DC$, of locomotion. This mechanism can save intermittent swimmers as much as 60 % of the energy it takes to swim continuously at the same speed. The inviscid energy savings are shown to increase with increasing amplitude of motion, increase with decreasing Lighthill number,$Li$, and switch to an energetic cost above continuous swimming for sufficiently low$DC$. Intermittent swimmers are observed to shed four vortices per cycle that give rise to an asymmetric time-averaged jet structure with both momentum surplus and deficit branches. In addition, previous thrust and power scaling laws of continuous self-propelled swimming are further generalized to include intermittent swimming. The key is that by averaging the thrust and power coefficients over only the bursting period then the intermittent problem can be transformed into a continuous one. Furthermore, the intermittent thrust and power scaling relations are extended to predict the mean speed and cost of transport of swimmers. By tuning a few coefficients with a handful of simulations these self-propelled relations can become predictive. In the current study, the mean speed and cost of transport are predicted to within 3 % and 18 % of their full-scale values by using these relations.
The wave-induced flow of internal gravity wavepackets with arbitrary aspect ratio
Authors: van den Bremer T. S. , Sutherland B. R. 
Published: November 2017

We examine the wave-induced flow of small-amplitude, quasi-monochromatic, three-dimensional, Boussinesq internal gravity wavepackets in a uniformly stratified ambient. It has been known since Bretherton (J. Fluid Mech., vol. 36 (4), 1969, pp. 785–803) that one-, two- and three-dimensional wavepackets induce qualitatively different flows. Whereas the wave-induced mean flow for compact three-dimensional wavepackets consists of a purely horizontal localized circulation that translates with and around the wavepacket, known as the Bretherton flow, such a flow is prohibited for a two-dimensional wavepacket of infinite spanwise extent, which instead induces a non-local internal wave response that is long compared with the streamwise extent of the wavepacket. One-dimensional (horizontally periodic) wavepackets induce a horizontal, non-divergent unidirectional flow. Through perturbation theory for quasi-monochromatic wavepackets of arbitrary aspect ratio, we predict for which aspect ratios which type of induced mean flow dominates. We compose a regime diagram that delineates whether the induced flow is comparable to that of one-, two- or compact three-dimensional wavepackets. The predictions agree well with the results of fully nonlinear three-dimensional numerical simulations.
Development of Spanish rhotics in Spanish–English bilingual children in the United States
Authors: MENKE Mandy R. 
Published: November 2017

AbstractRhotics, particularly the trill, are late acquired sounds in Spanish. Reports of Spanish–English bilingual preschoolers document age-appropriate articulations, but studies do not explore productions once exposure to English increases. This paper reports on the rhotic productions of a cross-sectional sample of 31 Spanish–English bilingual children, ages 6;8 to 13;5. Children produced taps with high rates of accuracy across age groups; the trill did not reach 80% target production until age 11;3, later than reported for monolingual speakers. Increased English exposure is explored as a contributing factor, arguing a need for continued study of bilingual phonological development beyond the preschool years.
Hepatitis E virus infection in North Italy: high seroprevalence in swine herds and increased risk for swine workers
Authors: MUGHINI-GRAS L. , ANGELONI G. , SALATA C. , VONESCH N. , D'AMICO W. , CAMPAGNA G. , NATALE A. , ZULIANI F. , CEGLIE L. , MONNE I. , VASCELLARI M. , CAPELLO K. , DI MARTINO G. , INGLESE N. , PALÙ G. , TOMAO P. , BONFANTI L. 
Published: November 2017

SUMMARYWe determined the hepatitis E virus (HEV) seroprevalence and detection rate in commercial swine herds in Italy's utmost pig-rich area, and assessed HEV seropositivity risk in humans as a function of occupational exposure to pigs, diet, foreign travel, medical history and hunting activities. During 2011–2014, 2700 sera from 300 swine herds were tested for anti-HEV IgG. HEV RNA was searched in 959 faecal pools from HEV-seropositive herds and in liver/bile/muscle samples from 179 pigs from HEV-positive herds. A cohort study of HEV seropositivity in swine workers (n = 149) was also performed using two comparison groups of people unexposed to swine: omnivores (n = 121) and vegetarians/vegans (n = 115). Herd-level seroprevalence was 75·6% and was highest in farrow-to-feeder herds (81·6%). Twenty-six out of 105 (24·8%) herds had HEV-positive faecal samples (25 HEV-3, one HEV-4). Only one bile sample tested positive. HEV seropositivity was 12·3% in swine workers, 0·9% in omnivores and 3·0% in vegetarians/vegans. Factors significantly associated with HEV seropositivity were occupational exposure to pigs, travel to Africa and increased swine workers’ age. We concluded that HEV is widespread in Italian swine herds and HEV-4 circulation is alarming given its pathogenicity, with those occupationally exposed to pigs being at increased risk of HEV seropositivity.
In-row Vegetation-free Strip Width Effect on Established ‘Navaho’ Blackberry
Authors: Basinger Nicholas T. , Jennings Katherine M. , Monks David W. , Mitchem Wayne E. , Perkins-Veazie Penelope M. , Chaudhari Sushila 
Published: November 2017

AbstractA field study was conducted in 2014 and 2015 in an established 5-yr old commercial blackberry planting to determine the effect of vegetation-free strip width (VFSW) on ‘Navaho’ blackberry vegetative growth, yield and fruit quality parameters, identify the optimum VFSW for blackberry plantings in the southeastern USA, and provide practical groundcover management recommendations that can increase the productivity of blackberry plantings. In Fall 2013, tall fescue was seeded in-row and allowed to establish. In Spring 2014, VFSW treatments (0, 0.6, 0.9, 1.2, and 1.8 m) were established in a randomized complete block statistical design with four replications. Blackberry growth measurements included primocane and floricane number, cane diam, individual fruit weight and yield. Fruit quality measurements included, soluble solids concentration (SSC), titratable acidity (TA) and pH. Primocane number increased with increasing VFSW in both years. Floricane number increased with increasing VFSW in 2014. Primocane diam decreased with increasing VFSW in 2014 but had a quadratic response in 2015. Berry weight and cumulative yield increased with increasing VFSW in both years. The only berry quality component affected by VFSW was pH, which decreased as VFSW increased. Results indicate that widening the VFSW in blackberry from the current recommendation of 1.2 m to 1.8 m could provide growers a means to increase plant growth, berry weight, and cumulative yield blackberry of a planting.