bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of local IL‐4 delivery or CCL2 blockade on implant fixation and bone structural properties in a mouse model of wear particle induced osteolysis
Authors: Sato Taishi , Pajarinen Jukka , Behn Anthony , Jiang Xinyi , Lin Tzu‐hua , Loi Florence , Yao Zhenyu , Egashira Kensuke , Yang Fan , Goodman Stuart B. 
Published: April 2016

AbstractModulation of macrophage polarization and prevention of CCL2‐induced macrophage chemotaxis are emerging strategies to reduce wear particle induced osteolysis and aseptic total joint replacement loosening. In this study, the effect of continuous IL‐4 delivery or bioactive implant coating that constitutively releases a protein inhibitor of CCL2 signaling (7ND) on particle induced osteolysis were studied in the murine continuous femoral intramedullary particle infusion model. Polyethylene particles with or without IL‐4 were infused into mouse distal femurs implanted with hollow titanium rods using subcutaneous infusion pumps. In another experimental group, particles were infused into the femur through a 7ND coated rod. After 4 weeks, fixation of the implant was assessed using a pullout test. The volume of trabecular bone and the geometry of the local cortical bone were assessed by µCT and the corresponding structural properties of the cortical bone determined by torsional testing. Continuous IL‐4 delivery led to increased trabecular bone volume as well as enhanced local bone geometry and structural properties, while 7ND implant coating did not have effect on these parameters. The results suggest that local IL‐4 treatment is a promising strategy to mitigate wear particle induced osteolysis. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2255–2262, 2016.
Stiffness‐controlled three‐dimensional collagen scaffolds for differentiation of human Wharton's jelly mesenchymal stem cells into cardiac progenitor cells
Authors: Lin Yun‐Li , Chen Chie‐Pein , Lo Chun‐Min , Wang Hwai‐Shi 
Published: April 2016

AbstractStem cell‐based regenerative therapy has emerged as a promising treatment for myocardial infarction. The aim of this study is to develop stiffness‐controlled collagen scaffolds to allow proliferation and differentiation of mesenchymal stem cell (MSCs) into cardiac progenitor cells. In this study transforming growth factor β2 (TGF‐β2), was used to induce stem cell differentiation into cardiac lineage cells. Collagen scaffolds were cross‐linked with cross‐linkers, 1‐Ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide (EDC), and N‐Hydroxysuccinimide (NHS). The results showed that collagen scaffolds cross‐linked with 25/50 and 50/50 of EDC mM/NHS mM cross‐linkers exhibited little difference in shape and size, the scaffold cross‐linked with 50/50 of cross‐linkers demonstrated better interconnectivity and higher Young's modulus (31.8 kPa) than the other (15.4 kPa). SEM observation showed that MSCs could grow inside the scaffolds and interact with collagen scaffolds. Furthermore, greater viability and cardiac lineage differentiation were achieved in MSCs cultured on stiffer scaffolds. The results suggest that three‐dimensional type I collagen scaffolds with suitable cross‐linking to adjust for stiffness can affect MSC fate and direct the differentiation of MSCs into cardiac progenitor cells with/without TGF‐β2. These stiffness‐controlled collagen scaffolds hold great potential as carriers for delivering MSCs differentiated cardiac progenitor cells into infracted hearts. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2234–2242, 2016.
Enzymatic Synthesis of Novel Bavachinin Glucoside by UDP‐glycosyltransferase
Authors: Dai Yiqun , Ma Tao , Ge Min , Li Jing , Huo Qiang , Li Hong‐Mei , Zhang Xinyu , Liu Hao , Wu Cheng‐Zhu 
Published: April 2016

AbstractBavachinin, a member of the flavanone subclass of flavonoids, has long been considered to have various biological activities. Here, the synthesis of novel bavachinin glucoside by the in vitro glycosylation reaction was successfully achieved using a UDP‐glucosyltransferase YjiC, from Bacillus licheniformis DSM‐13. The chemical structure of bavachinin glucoside was characterized based on spectroscopic techniques as bavachinin‐4′‐O‐ß‐D‐glucopyranoside (1). The water‐solubility of bavachinin‐4′‐O‐ß‐D‐glucopyranoside was found to be 9.96 μM, about 10 times higher than bavachinin. In addition, compound 1 showed moderate anti‐proliferative activity against four human tumor cell lines, with IC50 values ranging from 48.5 to 61.4 μM.
Predictors of Treatment Attrition Among Adult Outpatients With Clinically Significant Suicidal Ideation
Authors: Hom Melanie A. , Joiner Thomas E. 
Published: April 2016

ObjectiveTo identify demographic, diagnostic, and personality factors that predict treatment dropout in a sample of outpatients with clinically significant suicidal ideation.MethodA total of 287 adult outpatients at elevated risk for suicide completed self‐report measures of demographics, suicidal and depression symptoms, and personality characteristics at treatment intake. Clinician‐assessed psychiatric diagnoses and ratings of overall functioning also were collected.ResultsLower overall functioning (odds ratio [OR] = .947; 95% confidence interval [CI] [.909, .987]) and the presence of a substance use disorder (OR = 4.543; 95% CI [1.058, 19.499]) were the most robust predictors of attrition. Dropouts also were more likely to have a depressive disorder, more comorbid diagnoses, and more severe depression and suicidal symptoms.ConclusionsFindings suggest that clinician‐assessed poorer overall functioning and a substance use disorder diagnosis are risk factors for attrition among suicidal individuals, above and beyond other symptom measures. Further research is warranted to investigate attrition in additional outpatient samples.
Production of organics from CO2 by microbial electrosynthesis (MES) at high temperature
Authors: Faraghiparapari Neda , Zengler Karsten 
Published: April 2016

AbstractBACKGROUNDMicrobial electrosynthesis (MES), a process by which microorganisms reduce carbon dioxide to multi‐carbon compounds using electrical current as energy source, has so far been demonstrated at temperatures ranging from 25 °C to 37 °C. Elevated operating temperatures, however, could improve overall performance and product recovery. Here the effect of temperature on MES by the acetogenic thermophiles Moorella thermoacetica and Moorella thermoautotrophica is investigated.RESULTSExperiments were performed at operating temperatures ranging from 25 °C to 70 °C to determine the optimum operating temperature for MES. Optimal performance was observed to be close to the optimum growth temperatures reported for these strains. Production rate and activation energy of acetate at 60 °C was 6.9 ± 0.6 mM m−2 d−1 and 45.1 ± 3.8 kJ mol−1 for M. thermoacetica and 11.6 ± 0.9 mM m−2 d−1 and 58.9 ± 2.5 kJ mol−1 for M. thermoautotrophica with columbic efficiencies (CE) of 79 ± 15% and 72 ± 4%, respectively.CONCLUSIONConsidering CE and acetate production rate during MES, M. thermoautotrophica outperformed M. thermoacetica over a wide range of operating temperatures. Current‐dependent reduction of CO2 also occurred below the minimum growth temperature of these strains, suggesting that MES is non‐growth associated. © 2016 Society of Chemical Industry
Characterizing and exploring the mechanism of formation of corrosion scales by reusing advanced‐softened, silica‐rich, oilfield‐produced water (ASOW) in a steam‐injection boiler
Authors: Dai Xiaohu , Xu Ying , Shen Danni , Zhai Xiaoyu , Dong Bin , Lin Senming 
Published: April 2016

ABSTRACTBACKGROUNDCorrosion scales, which very strongly affect the thermal efficiency and security of boilers, are formed on the furnace tubes of the radiant section during the process of reusing advanced‐softened, silica‐rich, oilfield‐produced water (ASOW) as boiler feedwater in oilfields. To evaluate the reuse and to explore the composition and formation of corrosion scales a 16‐month pilot‐scale test was conducted.RESULTSThe silicon content and total hardness in the boiler feedwater were 238.93 mg L−1 and 0.031 mg L−1, respectively. Morphology and compositions of the corrosion scales were determined by scanning electron microscopy–energy dispersive spectrometry (SEM‐EDS), inductively coupled plasma–mass spectroscopy (ICP‐MS), X‐ray diffraction (XRD), and X‐ray photoelectron spectroscopy (XPS). These were measured both during the early stage of steam injection (ESSI) and the later stage of steam injection (LSSI). Iron oxides (Fe3O4, Fe2O3) were the main crystalline phases identified in the ESSI, while Acmite (NaFeSi2O6) was the primary crystalline phase in the LSSI. Based on the results, formation of the main corrosion scales are explained.CONCLUSIONIt can be concluded that NaFeSi2O6 is the reaction product of Fe2O3, H2SiO3 (gas), and Na2CO3 in the saturated steam. These results can offer an important reference for reusing the ASOW as feedwater and for reducing the corrosion scales in steam‐injection boiler. © 2016 Society of Chemical Industry
The value of FDG‐PET in the staging of gastric adenocarcinoma: A single institution retrospective review
Authors: Serrano Oscar K. , Love Charito , Goldman Inessa , Huang Kevin , Ng Nicole , Abraham Tony , Da Silva Raphaella , Friedmann Patricia , Libutti Steven K. , Kennedy Timothy J. 
Published: April 2016

BackgroundThe value of FDG‐PET in the staging of gastric adenocarcinoma (GA) has been subject to debate.MethodsWe performed a retrospective review of GA patients between 2006 and 2014 and identified those who had a CT and FDG‐PET before initiating treatment. CT and FDG‐PET images were analyzed by a blinded body radiologist and nuclear physician, respectively. Disease stage was assessed, looking at primary tumor (PT), locoregional (LLN) and distant lymph node disease (DLN), and metastasis (M).ResultsWe identified 608 patients who had biopsy‐proven GA and 207 (34.0%) had a CT and FDG‐PET as part of their staging work‐up. Of these, imaging from 166 (27.3%) patients was available for review. CT identified PT, LLN, DLN, and M in 120 (72.3%), 84 (50.6%), 25 (15.1%), and 32 (19.3%) patients, respectively; while FDG‐PET identified PT, LLN, DLN, and M in 125 (75.3%), 78 (47.0%), 41 (24.7%), and 27 (16.3%) of patients, respectively. FDG‐PET up‐staged 31 (18.7%) patients while it down‐staged 17 (10.2%) patients. Of patients who were up‐staged, 20 (64.5%) developed progressive disease.ConclusionsOur findings support the use of FDG‐PET as a valuable adjunct to CT in the staging of GA, as it changed the stage in 48 (28.9%) patients. J. Surg. Oncol. 2016;113:640–646. © 2016 Wiley Periodicals, Inc.
Over‐vibration induced blood perfusion and vascular permeability changes may lead to vocal edema
Authors: Wang Jiajia , Devine Erin , Fang Rui , Jiang Jack J. 
Published: April 2016

Objectives/HypothesisTo observe blood perfusion and vascular permeability changes under varying vibration frequency exposures.Study DesignAnimal model.MethodsBlood perfusion was measured using laser Doppler flowmetry in eight rabbit auricular vessels (four rabbits) under nonvibration, and 62.5‐Hz/1‐mm, 125‐Hz/1‐mm, and 250‐Hz/0.5‐mm vibration frequency/amplitude exposures. Another 12 rabbits were randomly divided into vibration only and vibration with histamine groups. After 3 hours of continuous 125‐Hz, 1‐mm amplitude vibration of the auricle, vascular permeability was analyzed by absorbance of Evans blue–albumin complex.ResultsSignificantly lower blood perfusion was observed in the vibration group, compared with no vibration exposure controls. Blood perfusion decreased 29 ± 16% as the vibration frequency was increased from 62.5 Hz to 125 Hz with the vibration amplitude constant at 1 mm. When the frequency was increased from 125 Hz to 250 Hz, while the amplitude was decreased from 1 mm to 0.5 mm, blood flow perfusion further decreased 29 ± 29%, and the decline tendency in blood perfusion showed no significant difference (P = .992). Meanwhile, in the vibration with histamine group, vascular permeability of the vibrated ears increased significantly compared to the nonvibrated ears (P = .005).ConclusionsOvervibration of the vocal folds due to voice overuse or abuse may significantly reduce blood perfusion, and increase vascular permeability in the vocal fold in inflammatory situations, which may lead to the formation of vocal edema.Level of EvidenceNA Laryngoscope, 127:148–152, 2017
Arytenoid adduction combined with nerve‐muscle pedicle flap implantation or type I thyroplasty
Authors: Kodama Narihiro , Kumai Yoshihiko , Sanuki Tetsuji , Yumoto Eiji 
Published: April 2016

Objectives/HypothesisTo evaluate vocal function after refined nerve‐muscle pedicle (NMP) flap implantation with arytenoid adduction (AA) compared with type I thyroplasty with AA for patients with unilateral vocal fold paralysis (UVFP) and to evaluate the degree of patient satisfaction following the refined NMP with AA.Study DesignA retrospective review of clinical records of 52 patients with UVFP who received AA + NMP (NMP group, n = 40) or AA + type I thyroplasty (type I group, n = 12) as a single‐stage operation between April 1999 and December 2011.MethodsEvaluation of vocal fold vibration, aerodynamic analysis, perceptual evaluation, acoustic analysis, and subjective assessment were performed preoperatively and at two different postoperative periods (short term: within 3 months and long term: >12 months).ResultsAll parameters except for glottal gap of the vocal fold vibration, maximum phonation time (MPT), and mean airflow rate revealed significant improvement between the short‐ and long‐term assessments in the NMP group. On the contrary, the type I group did not show significant change of any parameters during postoperative periods. In the NMP group, the measurements for regularity of the vocal fold vibration and MPT at the long‐term assessment were significantly favorable compared with the type I group. In the NMP group, subjective assessment (Voice Handicap Index‐10 and Voice‐Related Quality of Life) revealed significant improvement between the short‐ and long‐term assessments.ConclusionsIn comparison with the type I group, significant improvement of vocal function patient satisfaction during the long‐term follow‐up period after AA combined with the refined NMP was confirmed.Level of Evidence4. Laryngoscope, 127:159–166, 2017
The starship children's hospital tonsillectomy: A further 10 years of experience
Authors: Mahadevan Murali , van der Meer Graeme , Gruber Maayan , Reed Peter , Jackson Conor , Brown Colin , Mills Nikki , Salkeld Lesley J. , Neeff Michel , Evans Jan , Anderson Brian , Barber Colin 
Published: April 2016

Objectives/HypothesisTonsillectomy as a day‐stay procedure remains controversial, although it is an established procedure in New Zealand. We reviewed our last 10 years' experience.MethodsA prospective audit was used to determine unplanned conversion from day‐stay to overnight hospital admission rates and the incidence of postoperative complications.ResultsThere were 5,400 tonsillectomies performed over the 10‐year study period (January 2004–January 2015); 71% as outpatients. The unplanned conversion rate to overnight stay was 0.4%. The median age of day‐stay patients was 6.5 years (range 13 months–15 years) compared with those admitted for overnight stay (5 years; range 8 months–15 years). The primary postoperative bleed rate was 0.5% (confidence interval [CI] 0.3%–0.7%), and the combined primary and secondary posttonsillectomy bleed rate was 4.3% (CI 3.8%–5.0%). The rate of patients returning with postoperative complications within 1 month of surgery was 6.3% (CI 5.6%–7.0%).ConclusionDay‐stay tonsillectomy in the pediatric population is safe when performed using the described guidelines in a facility with appropriate resources.Level of Evidence4. Laryngoscope, 126:E416–E420, 2016
Vascularized fibular grafts extended with vascularized periosteum in children
Authors: Soldado Francisco , Diaz‐Gallardo Paula , Sena‐Cabo Lidia , Torner Ferran , Bergua‐Domingo Josep , Mascarenhas Vasco V. , Knorr Jorge 
Published: April 2016

PurposeThe purpose of this report is to evaluate the results of extending vascularized fibular grafts (VFG) with vascularized periosteum (VPG) in bone defect reconstruction in children.MethodsRetrospective study of 10 children, mean age at surgery was 9.8 years (range, 4–16 years). Origin of one defect was oncological (n = 5), septical (n = 2), traumatic (n = 2), or congenital (n = 1). In five cases the flap consisted of a VFG and a vascularized epiphyseal transfer (VFET) in five. Mean bone defect was 8.5 cm .Mean length of the vascularized periosteal extension was 5.5 cm (range 3.5–8) for VFET, 4.8 cm for VFG (range 3–8). Bone union was assessed with monthly radiographs.ResultsRadiographs showed a periosteal callus at 4 weeks in all cases. Bone union was achieved at a mean of 8.4 weeks (range 4–12). Donor site complications included two cases of flexor hallucis longus contracture, and one case of surgical wound marginal necrosis following FVG. One transient tibialis anterior weakness and one tibialis anterior contracture occurred following VFET harvest. None required surgical treatment. Mean follow‐up was 28.7 months (range 7–72).ConclusionsThe association of a vascularized periosteal extension with fibular flaps seems to accelerate flap to recipient bone union. © 2016 Wiley Periodicals, Inc. Microsurgery 37:410–415, 2017.
A fast chemical exchange saturation transfer imaging scheme based on single‐shot spatiotemporal encoding
Authors: Huang Jianpan , Zhang Miao , Lu Jianhua , Cai Congbo , Chen Lin , Cai Shuhui 
Published: April 2016

PurposeTo design a new approach that can not only keep the spatial and temporal resolution but also have better built‐in immunity to magnetic field inhomogeneity and chemical shift effects than the single‐shot echo planar imaging (EPI) for chemical exchange saturation transfer (CEST) MRI.MethodThe single‐shot spatiotemporally encoded (SPEN) MRI sequence was combined with a continuous wave saturation pulse for fast CEST MRI (CEST‐SPEN MRI). The resulting images were super‐resolved reconstructed by a hybrid method that solves the l1 norm minimization together with total variation (TV) regularization. Partial Lorentzian fitting was used to analyze the subsequent Z‐spectra.ResultsExperimental results of a creatine phantom and in vivo tumor rat brains show that CEST‐SPEN MRI has good capability in providing CEST‐based and NOE‐based contrast images.ConclusionsCompared with CEST‐EPI, CEST‐SPEN MRI has better immunity to magnetic field inhomogeneity and provides better contrast images within identical acquisition time, especially under an identical inhomogeneous field. Magn Reson Med 77:1786–1796, 2017. © 2016 International Society for Magnetic Resonance in Medicine
Schur complement‐based domain decomposition preconditioners with low‐rank corrections
Authors: Li Ruipeng , Xi Yuanzhe , Saad Yousef 
Published: April 2016

SummaryThis paper introduces a robust preconditioner for general sparse matrices based on low‐rank approximations of the Schur complement in a Domain Decomposition framework. In this ‘Schur Low Rank’ preconditioning approach, the coefficient matrix is first decoupled by a graph partitioner, and then a low‐rank correction is exploited to compute an approximate inverse of the Schur complement associated with the interface unknowns. The method avoids explicit formation of the Schur complement. We show the feasibility of this strategy for a model problem and conduct a detailed spectral analysis for the relation between the low‐rank correction and the quality of the preconditioner. We first introduce the SLR preconditioner for symmetric positive definite matrices and symmetric indefinite matrices if the interface matrices are symmetric positive definite. Extensions to general symmetric indefinite matrices as well as to nonsymmetric matrices are also discussed. Numerical experiments on general matrices illustrate the robustness and efficiency of the proposed approach. Copyright © 2016 John Wiley & Sons, Ltd.
What factors influence ward nurses’ recognition of and response to patient deterioration? An integrative review of the literature
Authors: Massey Debbie , Chaboyer Wendy , Anderson Vinah 
Published: April 2016

AbstractAimIn this integrative review, we aimed to: first, identify and summarize published studies relating to ward nurses' recognition of and response to patient deterioration; second, to critically evaluate studies that described or appraised the practice of ward nurses in recognizing and responding to patient deterioration; and third, identify gaps in the literature for further research.DesignAn integrative review.MethodsThe Cumulative Index to Nursing and Allied Health Literature (CINAHL) Ovid Medline, Informit and Google Scholar databases were accessed for the years 1990–2014. Data were extracted and summarized in tables and then appraised using the Mixed Method Appraisal Tool. Data were grouped into two domains; recognizing and responding to deterioration and then thematic analysis was used to identify the emerging themes.ResultsSeventeen studies were reviewed and appraised. Recognizing patient deterioration was encapsulated in four themes: (1) assessing the patient; (2) knowing the patient; (3) education and (4) environmental factors. Responding to patient deterioration was encapsulated in three themes; (1) non‐technical skills; (2) access to support and (3) negative emotional responses.ConclusionIssues involved in timely recognition of and response to clinical deterioration remain complex, yet patient safety relies on nurses’ timely assessments and actions.
Schedule for personality assessment from notes and documents (SPAN‐DOC): Preliminary validation, links to the ICD‐11 classification of personality disorder, and use in eating disorders
Authors: Kim Youl‐Ri , Tyrer Peter , Lee Hong‐Seock , Kim Sung‐Gon , Connan Frances , Kinnaird Emma , Olajide Kike , Crawford Mike 
Published: April 2016

AbstractBackgroundThe underlying core of personality is insufficiently assessed by any single instrument. This has led to the development of instruments adapted for written records in the assessment of personality disorder.AimsTo test the construct validity and inter‐rater reliability of a new personality assessment method.MethodThis study (four parts) assessed the construct validity of the Schedule for Personality Assessment from Notes and Documents (SPAN‐DOC), a dimensional assessment from clinical records. We examined inter‐rater reliability using case vignettes (Part 1) and convergent validity in three ways: by comparison with NEO Five‐Factor Inventory in 130 Korean patients (Part 2), with agreed ICD‐11 personality severity levels in two populations (Part 3) and determining its use in assessing the personality status in 90 British patients with eating disorders (Part 4).ResultsInternal consistency (alpha = .90) and inter‐rater reliability (intraclass correlation coefficient ≥ .88) were satisfactory. Each factor in the five‐factor model of personality was correlated with conceptually valid SPAN‐DOC variables. The SPAN‐DOC domain traits in those with eating disorders were categorized into 3 clusters: self‐aggrandisement, emotionally unstable, and anxious/dependent.ConclusionsThis study provides preliminary support for the usefulness of SPAN‐DOC in the assessment of personality disorder. Copyright © 2016 John Wiley & Sons, Ltd.