bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peroxidase‐Mimicking Nanozyme with Enhanced Activity and High Stability Based on Metal–Support Interactions
Authors: Li Zhihao , Yang Xiangdong , Yang Yanbing , Tan Yaning , He Yue , Liu Meng , Liu Xinwen , Yuan Quan 
Published: October 2017

AbstractPeroxidase‐mimicking nanozymes offer unique advantages in terms of high stability and low cost over natural peroxidase for applications in bioanalysis, biomedicine, and the treatment of pollution. However, the design of high‐efficiency peroxidase‐mimicking nanozymes remains a great challenge. In this study, we adopted a structural‐design approach through hybridization of cube‐CeO2 and Pt nanoparticles to create a new peroxidase‐mimicking nanozyme with high efficiency and excellent stability. Relative to pure cube‐CeO2 and Pt nanoparticles, the as‐hybridized Pt/cube‐CeO2 nanocomposites display much improved activities because of the strong metal–support interaction. Meanwhile, the nanocomposites also maintain high catalytic activity after long‐term storage and multiple recycling. Based on their excellent properties, Pt/cube‐CeO2 nanocomposites were used to construct high‐performance colorimetric biosensors for the sensitive detection of metabolites, including H2O2 and glucose. Our findings highlight opportunities for the development of high‐efficiency peroxidase‐mimicking nanozymes with potential applications such as diagnostics, biomedicine, and the treatment of pollution.
C9/12 Ribbon‐Like Structures in Hybrid Peptides Alternating α‐ and Thiazole‐Based γ‐Amino Acids
Authors: Bonnel Clément , Legrand Baptiste , Simon Matthieu , Martinez Jean , Bantignies Jean‐Louis , Kang Young Kee , Wenger Emmanuel , Hoh Francois , Masurier Nicolas , Maillard Ludovic T. 
Published: October 2017

AbstractAccording to their restricted conformational freedom, heterocyclic γ‐amino acids are usually considered to be related to Z‐vinylogous γ‐amino acids. In this context, oligomers alternating α‐amino acids and thiazole‐based γ‐amino acids (ATCs) were expected to fold into a canonical 12‐helical shape as described for α/γ‐hybrid peptides composed of cis‐α/β‐unsaturated γ‐amino acids. However, through a combination of X‐ray crystallography, NMR spectroscopy, FTIR experiments, and DFT calculations, it was determined that the folding behavior of ATC‐containing hybrid peptides is much more complex. The homochiral α/(S)‐ATC sequences were unable to adopt a stable conformation, whereas the heterochiral α/(R)‐ATC peptides displayed novel ribbon structures stabilized by unusual C9/12‐bifurcated hydrogen bonds. These ribbon structures could be considered as a succession of pre‐organized γ/α dipeptides and may provide the basis for designing original α‐helix mimics.
Synergistic Hydrogenation over Palladium through the Assembly of MIL‐101(Fe) MOF over Palladium Nanocubes
Authors: Bakuru Vasudeva Rao , Kalidindi Suresh Babu 
Published: October 2017

AbstractEnhancing catalytic performance of metal nanoparticles is highly sought for many industrial catalytic processes. In this regard, assembly of crystalline porous super‐tunable metal–organic frameworks (MOFs) around preformed metal nanoparticles is an attractive prospect as this strongly influences the activity of the entire nanoparticle surface. Herein, we assembled a MlL‐101(Fe) MOF onto the Pd nanocubes and evaluated the catalytic properties of the hybrid material for the hydrogenation of the α,β‐unsaturated carbonyl compounds cinnamaldehyde, crotonaldehyde, and β‐ionone. Owing to the synergestic effects originating from the Lewis acid sites present on MOF and Pd active sites, striking improvements in the activities and selectivities were observed for the Pd⊂MIL‐101(Fe) hybrid material. The turnover frequency (TOF) values increased up to roughly 20 fold and in all three studied substrates, C=C was preferentially hydrogenated compared to C=O. Furthermore, the Pd⊂MIL‐101(Fe) catalyst was readily reusable and highly stable.
Chemistry and Biology of Teixobactin
Authors: Guo Chuchu , Mandalapu Dhanaraju , Ji Xinjian , Gao Jiangtao , Zhang Qi 
Published: October 2017

AbstractBacterial resistance to existing drugs is becoming a serious public health issue, urging extensive search for new antibiotics. Teixobactin, a cyclic depsipeptide discovered in a screen of uncultured bacteria, shows potent activity against all the tested Gram‐positive bacteria. Remarkably, no teixobactin‐resistant bacterial strain has been obtained despite extensive efforts, highlighting the great potential of teixobactin as a lead compound in the fight against antimicrobial resistance (AMR). This review summarizes recent progresses in the understanding of many aspects of teixobactin, including chemical structure, biological activity, biosynthetic pathway, and mode of action. We also discuss the different synthetic strategies in producing teixobactin and its analogues, and the structure–activity relationship (SAR) studies.
Highly K+‐Selective Fluorescent Probes for Lifetime Sensing of K+ in Living Cells
Authors: Schwarze Thomas , Mertens Monique , Müller Peter , Riemer Janine , Wessig Pablo , Holdt Hans‐Jürgen 
Published: October 2017

AbstractInvited for the cover of this issue is the groups of Pablo Wessig and Hans‐Jürgen Holdt at the University of Potsdam. The image depicts a fluorescent probe consisting of the highly K+‐selective N‐(o‐isopropoxy)phenylaza‐18‐crown‐6 ionophore and the bright [1,3]dioxolo[4,5‐f][1,3]benzodioxole fluorophore. Read the full text of the article at 10.1002/chem.201703799.
Likelihood inflating sampling algorithm
Authors: Entezari Reihaneh , Craiu Radu V. , Rosenthal Jeffrey S. 
Published: October 2017

AbstractMarkov Chain Monte Carlo (MCMC) sampling from a posterior distribution corresponding to a massive data set can be computationally prohibitive as producing one sample requires a number of operations that is linear in the data size. In this article we introduce a new communication‐free parallel method, the “Likelihood Inflating Sampling Algorithm (LISA),” that significantly reduces computational costs by randomly splitting the data set into smaller subsets and running MCMC methods “independently” in parallel on each subset using different processors. Each processor will be used to run an MCMC chain that samples sub‐posterior distributions which are defined using an “inflated” likelihood function. We develop a strategy for combining the draws from different sub‐posteriors to study the full posterior of the Bayesian Additive Regression Trees (BART) model. The performance of the method is tested using simulated data and a large socio‐economic study. The Canadian Journal of Statistics 46: 147–175; 2018 © 2017 Statistical Society of Canada
Identification of vivianite, an unusual blue pigment, in a sixteenth century painting and its implications
Authors: Cruz António João , Eires Erica , Dias Luís , Desterro Teresa , Rego Carla 
Published: October 2017

AbstractVivianite, a blue pigment employed in the past practically only in Northern and Central Europe, but with very limited use, was identified in an early sixteenth century painting, stylistically with Flemish features, from a church in Portugal. The identification of this iron phosphate mineral was made by SEM‐EDS based on the atomic ratio between phosphorus and iron in layers of blue paint (area analysis) and in particles of these same layers (spot analysis). This painting, about which there is no document to prove its authorship, becomes the first case, known in detail, of a sixteenth century painting containing vivianite. Moreover, this find and the presence of a chalk ground, also identified, strongly support the hypothesis of being a Flemish painting.
Development of a novel tissue‐mimicking color calibration slide for digital microscopy
Authors: Clarke Emily L. , Revie Craig , Brettle David , Shires Michael , Jackson Peter , Cochrane Ravinder , Wilson Robert , Mello‐Thoms Claudia , Treanor Darren 
Published: October 2017

AbstractDigital microscopy produces high resolution digital images of pathology slides. Because no acceptable and effective control of color reproduction exists in this domain, there is significant variability in color reproduction of whole slide images. Guidance from international bodies and regulators highlights the need for color standardization. To address this issue, we systematically measured and analyzed the spectra of histopathological stains. This information was used to design a unique color calibration slide utilizing real stains and a tissue‐like substrate, which can be stained to produce the same spectral response as tissue. By closely mimicking the colors in stained tissue, our target can provide more accurate color representation than film‐based targets, whilst avoiding the known limitations of using actual tissue. The application of the color calibration slide in the clinical setting was assessed by conducting a pilot user‐evaluation experiment with promising results. With the imminent integration of digital pathology into the routine work of the diagnostic pathologist, it is hoped that this color calibration slide will help provide a universal color standard for digital microscopy thereby ensuring better and safer healthcare delivery.
The Relative Bioavailability, Food Effect, and Drug Interaction With Omeprazole of Momelotinib Tablet Formulation in Healthy Subjects
Authors: Xin Yan , Shao Lixin , Maltzman Julie , Stefanidis Dimitrios , Hemenway Jeffrey , Tarnowski Thomas , Deng Wei , Silverman Jeffrey A. 
Published: October 2017

AbstractMomelotinib is a potent and selective small‐molecule inhibitor of JAK1/2 that is under investigation for the treatment of myeloproliferative neoplasms. In a phase 1/2 study in myelofibrosis patients, once‐daily dosing of a 300‐mg momelotinib capsule was selected for further development based on a favorable benefit:risk profile. A tablet formulation was recently developed for further clinical evaluation. In this study, the relative bioavailability of the tablet formulation versus the initial capsule formulation and the effect of food and omeprazole on the pharmacokinetics of a single‐dose momelotinib tablet were evaluated in healthy subjects. The momelotinib tablet, 200 mg, provided plasma exposure equivalent to the 300‐mg capsule. Plasma exposure of momelotinib increased less than dose‐proportionally from 100 to 800 mg. Food intake modestly increased Cmax (38% and 28% increase for low‐ and high‐fat meals, respectively) and AUCinf (16% and 28% increase for low‐ and high‐fat meals, respectively) for the momelotinib tablet. Omeprazole reduced the exposure of the momelotinib tablet by 36% for Cmax and 33% for AUCinf. Neither the food effect nor the omeprazole effect on momelotinib exposure was considered clinically meaningful because of the safety and efficacy profile of momelotinib.
In Situ TEM Studies of Nanostructured Thermoelectric Materials: An Application to Mg‐Doped Zn4Sb3 Alloy
Authors: Ngo Duc‐The , Hung Le Thanh , Van Nong Ngo 
Published: October 2017

AbstractWe demonstrate an advanced approach using state of the art in situ transmission electron microscopy (TEM) to understand the interplay between nanostructures and thermoelectric (TE) properties of high‐performance Mg‐doped Zn4Sb3 TE systems. By using the technique, microstructure and crystal evolutions of TE material have been dynamically captured as a function of temperature from 300 K to 573 K. On heating, we have clearly observed precipitation and growth of a Zn‐rich secondary phase as nanoinclusions in the matrix of primary Zn4Sb3 phase. Elemental mapping by STEM‐EDX spectroscopy reveals enrichment of Zn in the secondary Zn6Sb5 nanoinclusions during the thermal processing without decomposition. Such nanostructures strongly enhances phonon scattering, resulting in a decrease in the thermal conductivity leading to a zT value of 1.4 at 718 K.
Factors Influencing the Mechanical Properties of Formamidinium Lead Halides and Related Hybrid Perovskites
Authors: Sun Shijing , Isikgor Furkan H. , Deng Zeyu , Wei Fengxia , Kieslich Gregor , Bristowe Paul D. , Ouyang Jianyong , Cheetham Anthony K. 
Published: October 2017

AbstractInvited for this month′s cover is the group of Prof. Tony Cheetham and Dr. Paul Bristowe at the University of Cambridge, in collaboration with Dr. Gregor Kieslich at TU Munich and Prof. Jianyong Ouyang at the National University of Singapore. The Cover image shows how the structural–mechanical properties of hybrid perovskites can be determined by using a combination of nanoindentation measurements and crystallographic studies. The Communication itself is available at 10.1002/cssc.201700991.
Simple approximate phase cancellation for repetitive control of CVCF PWM inverters
Authors: Li Dapeng , Ye Yongqiang 
Published: October 2017

SummaryIn this paper, a simple approximate phase cancellation repetitive controller is proposed for a constant‐voltage constant‐frequency pulse‐width modulation inverter. The compensator is a linear combination of linear phase compensators, which can better fit the inverse of a plant model phase curve compared with the conventional linear phase compensator. Repetitive controllers with the proposed phase compensator can improve pulse‐width modulation inverter system's stability, tracking accuracy, and error convergence rate. An optimization method is applied to design the parameters of the proposed phase compensation repetitive controller. Analysis and design of the proposed repetitive controller are presented. Furthermore, simulations and experiments are provided to demonstrate the advantages of the approximate phase cancellation repetitive controller design.
Genome comparisons indicate recent transfer ofwRi‐likeWolbachiabetween sister speciesDrosophila suzukiiandD. subpulchrella
Authors: Conner William R. , Blaxter Mark L. , Anfora Gianfranco , Ometto Lino , Rota‐Stabelli Omar , Turelli Michael 
Published: October 2017

AbstractWolbachiaendosymbionts may be acquired by horizontal transfer, by introgression through hybridization between closely related species, or by cladogenic retention during speciation. All three modes of acquisition have been demonstrated, but their relative frequency is largely unknown.Drosophila suzukiiand its sister speciesD. subpulchrellaharborWolbachia, denotedwSuz andwSpc, very closely related towRi, identified in California populations ofD. simulans. However, these variants differ in their induced phenotypes:wRi causes significant cytoplasmic incompatibility (CI) inD. simulans, butCIhas not been detected inD. suzukiiorD. subpulchrella. Our draft genomes ofwSuz andwSpc contain full‐length copies of 703 of the 734 single‐copy genes found inwRi. Over these coding sequences,wSuz andwSpc differ by only 0.004% (i.e., 28 of 704,883 bp); they are sisters relative towRi, from which each differs by 0.014%–0.015%. Using published data fromD. melanogaster,Nasoniawasps andNomadabees to calibrate relative rates ofWolbachiaversus host nuclear divergence, we conclude thatwSuz andwSpc are too similar—by at least a factor of 100—to be plausible candidates for cladogenic transmission. These threewRi‐likeWolbachia, which differ inCIphenotype in their native hosts, have different numbers of orthologs of genes postulated to contribute toCI; and theCIloci differ at several nucleotides that may account for theCIdifference. We discuss the general problem of distinguishing alternative modes ofWolbachiaacquisition, focusing on the difficulties posed by limited knowledge of variation in absolute and relative rates of molecular evolution for host nuclear genomes, mitochondria, andWolbachia.
Experimental and Numerical Investigation of Contact Doping Effects in Dinaphthothienothiphene Thin‐Film Transistors
Authors: YAMAMOTO RYO , NODA KEI , WADA YASUO , TOYABE TORU 
Published: October 2017

SUMMARYContact doping effects in p‐channel dinaphthothienothiphene (DNTT) thin‐film transistors with a bottom‐gate, top‐contact configuration were investigated with both experimental and numerical approach. Characteristic variation in transistor parameters such as the gate threshold voltage and the field‐effect mobility for devices with various channel lengths was suppressed by the contact doping with tetrafluorotetracyanoquinodimethane (F4TCNQ) as an acceptor dopant. The gate‐voltage dependence of contact resistance and channel resistance was also evaluated separately to examine the contact doping effect in detail. In addition, device simulation considering a Schottky barrier at a metal/semiconductor interface successfully reproduced the experimental current–voltage characteristics by using a hole concentration of the active DNTT layer in the order of 1017 cm−3, which was estimated by capacitance–voltage measurement for a metal/insulator/semiconductor capacitor structure. This study suggests the importance of establishing both the carrier doping and carrier concentration measurements toward realizing practical applications of organic transistors.
An On‐Demand Safety Gas Generator for Solid Oxide Fuel Cell and Electrolyzer Systems
Authors: Engelbracht M. , Peters R. , Tiedemann W. , Hoven I. , Blum L. , Stolten D. 
Published: October 2017

AbstractWith their high electrochemical efficiency, solid oxide fuel cells (SOFCs) and solid oxide electrolyzers (SOEs) offer viable means of reducing energy sector greenhouse gas emissions and storing surplus renewably‐generated power. At present, these systems have operating temperatures of over 600 °C. During start‐up, following cooling or in an emergency shut‐off situation, a premixed safety gas is necessary which prevents damage to the cell's anode substrate. To date, safety gas has been industrially produced and stored in compressed gas cylinders. Given an SOFC system's size, these cylinders must be transported and stored in close proximity and replaced following gas expenditure. The storage space required, as well as the continuous replacement of gas cylinders, increases system size and costs. This paper presents a solution to this problem in the form of a specially developed safety gas generator that generates an on‐demand synthetic safety gas via the system's infrastructure. The functionality of this component is experimentally validated in tests conducted with a 4‐cell stack.
Two‐way Operations of a DMFC with a Vapor Feed and With a Liquid Feed
Authors: Saito J. , Ishitobi H. , Nakagawa N. 
Published: October 2017

AbstractUsing a cell module with a porous carbon plate, two‐way operations of a specific direct methanol fuel cell (DMFC) with a vapor feed (VF) of neat methanol and a liquid feed (LF) of a dilute methanol solution were conducted, and the cell performances were compared to each other in order to clarify which condition produced the better performance. The comparison was conducted at different air humidities, i.e., 30, 60, 90 and 100%, and cell temperatures, i.e., 313, 323 and 333 K. As a result, about a 10% higher power density was obtained by the LF‐DMFC, whereas about a 2% higher efficiency was obtained by the VF‐DMFC at the optimum air humidity and 323 K. These performances were achieved by significantly different mass transports through the membrane.
Eco‐Friendly and High Performance Supercapacitors for Elevated Temperature Applications Using Recycled Tea Leaves
Authors: Bhoyate Sanket , Ranaweera Charith K. , Zhang Chunyang , Morey Tucker , Hyatt Megan , Kahol Pawan K. , Ghimire Madhav , Mishra Sanjay R. , Gupta Ram K. 
Published: October 2017

AbstractUsed tea leaves are utilized for preparation of carbon with high surface area and electrochemical properties. Surface area and pore size of tea leaves derived carbon are controlled by varying the amount of KOH as activating agent. The maximum surface area of 2532 m2 g−1 is observed, which is much higher than unactivated tea leaves (3.6 m2 g−1). It is observed that the size of the electrolyte ions has a profound effect on the energy storage capacity. The maximum specific capacitance of 292 F g−1 is observed in 3 m KOH electrolyte with outstanding cyclic stability, while the lowest specific capacitance of 246 F g−1 is obtained in 3 m LiOH electrolyte at 2 mV s−1. The tea leaves derived electrode shows almost 100% capacitance retention up to 5000 cycles of study. The symmetrical supercapacitor device shows a maximum specific capacitance of 0.64 F cm−2 at 1 mA cm−2 and about 95% of specific capacitance is retained after increasing current density to 12 mA cm−2, confirming the high rate stability of the device. An improvement over 35% in the charge storage capacity is seen when increasing device temperature from 10 to 80 °C. The study suggests that used tea leaves can be used for the fabrication of environment friendly high performance supercapacitor devices at a low cost.
Reduced striato‐cortical and inhibitory transcallosal connectivity in the motor circuit of Huntington's disease patients
Authors: Garcia‐Gorro Clara , de Diego‐Balaguer Ruth , Martínez‐Horta Saul , Pérez‐Pérez Jesus , Kulisevsky Jaime , Rodríguez‐Dechicha Nadia , Vaquer Irene , Subira Susana , Calopa Matilde , Muñoz Esteban , Santacruz Pilar , Ruiz‐Idiago Jesús , Mareca Celia , Caballol Nuria , Camara Estela 
Published: October 2017

AbstractHuntington's disease (HD) is a neurodegenerative disorder which is primarily associated with striatal degeneration. However, the alterations in connectivity of this structure in HD have been underinvestigated. In this study, we analyzed the functional and structural connectivity of the left putamen, while participants performed a finger‐tapping task. Using fMRI and DW‐MRI, 30 HD gene expansion carriers (HDGEC) and 29 healthy participants were scanned. Psychophysiological interaction analysis and DTI‐based tractography were employed to examine functional and structural connectivity, respectively. Manifest HDGEC exhibited a reduced functional connectivity of the left putamen with the left and the right primary sensorimotor areas (SM1). Based on this result, the inhibitory functional connectivity between the left SM1 and the right SM1 was explored, appearing to be also decreased. In addition, the tract connecting these areas (motor corpus callosum), and the tract connecting the left putamen with the left SM1 appeared disrupted in HDGEC compared to controls. Significant correlations were found between measures of functional and structural connectivity of the motor corpus callosum, showing a coupling of both types of alterations in this tract. The observed reduction of functional and structural connectivity was associated with worse motor scores, which highlights the clinical relevance of these results. Hum Brain Mapp 39:54–71, 2018. © 2017 Wiley Periodicals, Inc.