bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple episodes of regional exhumation and inversion identified in the UK Southern North Sea based on integration of palaeothermal and palaeoburial indicators
Authors: Green Paul F. , Duddy Ian R. , Japsen Peter 
Published: March 2017

Abstract
We present a consistent synthesis of palaeothermal (apatite fission track analysis (AFTA) and vitrinite reflectance) data from UK Southern North Sea wells with the regional pattern of exhumation defined from sonic velocity data. Cenozoic exhumation across most of the region began in the Paleocene between 63 and 59 Ma. Amounts of removed section are around 1 km across the offshore platform, increasing to 2 km or more on the Sole Pit axis. Neogene exhumation within this area began between 22 and 15 Ma, and led to removal of up to 1 km of section. Along the eastern flank of the Sole Pit axis, sonic data define a pre-Chalk event, and AFTA data from these wells show that exhumation began between 120 and 93 Ma. This timing correlates with events defined from AFTA data in the Sorgenfrei–Tornquist Zone, further east, presumably reflecting a response to regional tectonic stresses. East of the Sole Pit axis, AFTA and sonic velocities suggest that Neogene exhumation dominates, while further east towards the central parts of the North Sea Mesozoic sediments appear to be at maximum burial today except for local effects related to salt movement. The multiple episodes of exhumation and burial defined here have important implications for exploration.
3D basin and petroleum system modelling of the NW German North Sea (Entenschnabel)
Authors: Arfai Jashar , Lutz Rüdiger 
Published: March 2017

Abstract
3D basin and petroleum system modelling covering the NW German North Sea (Entenschnabel) was performed to reconstruct the thermal history, maturity and petroleum generation of three potential source rocks, namely the Namurian–Visean coals, the Lower Jurassic Posidonia Shale and the Upper Jurassic Hot Shale.
Modelling results indicate that the NW study area did not experience the Late Jurassic heat flow peak of rifting as in the Central Graben. Therefore, two distinct heat flow histories are needed since the Late Jurassic to achieve a match between measured and calculated vitrinite reflection data. The Namurian–Visean source rocks entered the early oil window during the Late Carboniferous, and reached an overmature state in the Central Graben during the Late Jurassic. The oil-prone Posidonia Shale entered the main oil window in the Central Graben during the Late Jurassic. The deepest part of the Posidonia Shale reached the gas window in the Early Cretaceous, showing maximum transformation ratios of 97% at the present day. The Hot Shale source rock exhibits transformation ratios of up to 78% within the NW Entenschnabel and up to 20% within the Central Graben area. The existing gas field (A6-A) and oil shows in Chalk sediments of the Central Graben can be explained by our model.
The pterosaur assemblage of the Oxford Clay Formation (Jurassic, Callovian–Oxfordian) from the UK
Authors: O'Sullivan Michael 
Published: March 2017

Abstract

The Middle–Upper Jurassic Oxford Clay Formation of the UK is a highly productive fossiliferous unit, containing numerous fossils of marine and terrestrial vertebrates. Despite this abundance, pterosaurs make up only a tiny percentage of the assemblage. There are currently only seven specimens accessioned in the Oxford University Museum of Natural History and Natural History Museum, London. Of these, only one specimen (an association of material from a juvenile animal) has been named, identified as
Rhamphorhynchus jessoni
. Following a detailed examination, it is identified here as lacking any autapomorphies and the species
R
.
jessoni
is considered a
nomen dubium
. The other Oxford Clay Formation pterosaur fossils are similarly identified as indeterminate, except for an isolated scapulocoracoid which is positively identified as
Rhamphorhynchus
sp. The rarity of pterosaurs is attributed to a combination of the fragility of their bones and the tendency of volant animals to have low population densities at sea.
Endothelial dysfunction inhibits the ability of haptoglobin to prevent hemoglobin-induced hypertension
Authors: Graw Jan A. , Yu Binglan , Rezoagli Emanuele , Warren H. Shaw , Buys Emmanuel S. , Bloch Donald B. , Zapol Warren M. 
Published: March 2017

Intravascular hemolysis produces injury in a variety of human diseases including hemoglobinopathies, malaria, and sepsis. The adverse effects of increased plasma hemoglobin are partly mediated by depletion of nitric oxide (NO) and result in vasoconstriction. Circulating plasma proteins haptoglobin and hemopexin scavenge extracellular hemoglobin and cell-free heme, respectively. The ability of human haptoglobin or hemopexin to inhibit the adverse effects of NO scavenging by circulating murine hemoglobin was tested in C57Bl/6 mice. In healthy awake mice, the systemic hemodynamic effects of intravenous coinfusion of cell-free hemoglobin and exogenous haptoglobin or of cell-free hemoglobin and hemopexin were compared with the hemodynamic effects of infusion of cell-free hemoglobin or control protein (albumin) alone. We also studied the hemodynamic effects of infusing hemoglobin and haptoglobin as well as injecting either hemoglobin or albumin alone in mice fed a high-fat diet (HFD) and in diabetic ( db/ db) mice. Coinfusion of a 1:1 weight ratio of haptoglobin but not hemopexin with cell-free hemoglobin prevented hemoglobin-induced systemic hypertension in healthy awake mice. In mice fed a HFD and in diabetic mice, coinfusion of haptoglobin mixed with an equal mass of cell-free hemoglobin did not reverse hemoglobin-induced hypertension. Haptoglobin retained cell-free hemoglobin in plasma, but neither haptoglobin nor hemopexin affected the ability of hemoglobin to scavenge NO ex vivo. In conclusion, in healthy C57Bl/6 mice with normal endothelium, coadministration of haptoglobin but not hemopexin with cell-free hemoglobin prevents acute hemoglobin-induced systemic hypertension by compartmentalizing cell-free hemoglobin in plasma. In murine diseases associated with endothelial dysfunction, haptoglobin therapy appears to be insufficient to prevent hemoglobin-induced vasoconstriction.NEW & NOTEWORTHY Coadministraton of haptoglobin but not hemopexin with cell-free hemoglobin prevents hemoglobin-induced systemic hypertension in mice with a normal endothelium. In contrast, treatment with the same amount of haptoglobin is unable to prevent hemoglobin-induced vasoconstriction in mice with hyperlipidemia or diabetes mellitus, disorders that are associated with endothelial dysfunction.
Tumor-Localized Secretion of Soluble PD1 Enhances Oncolytic Virotherapy
Authors: Bartee Mee Y. , Dunlap Katherine M. , Bartee Eric 
Published: March 2017

Abstract
Oncolytic virotherapy represents an attractive option for the treatment of a variety of aggressive or refractory tumors. While this therapy is effective at rapidly debulking directly injected tumor masses, achieving complete eradication of established disease has proven difficult. One method to overcome this challenge is to use oncolytic viruses to induce secondary antitumor immune responses. Unfortunately, while the initial induction of these immune responses is typically robust, their subsequent efficacy is often inhibited through a variety of immunoregulatory mechanisms, including the PD1/PDL1 T-cell checkpoint pathway. To overcome this inhibition, we generated a novel recombinant myxoma virus (vPD1), which inhibits the PD1/PDL1 pathway specifically within the tumor microenvironment by secreting a soluble form of PD1 from infected cells. This virus both induced and maintained antitumor CD8+ T-cell responses within directly treated tumors and proved safer and more effective than combination therapy using unmodified myxoma and systemic αPD1 antibodies. Localized vPD1 treatment combined with systemic elimination of regulatory T cells had potent synergistic effects against metastatic disease that was already established in secondary solid organs. These results demonstrate that tumor-localized inhibition of the PD1/PDL1 pathway can significantly improve outcomes during oncolytic virotherapy. Furthermore, they establish a feasible path to translate these findings against clinically relevant disease. Cancer Res; 77(11); 2952–63. ©2017 AACR.
Acute Changes in Left Atrial Pressure After MitraClip Are Associated With Improvement in 6-Minute Walk Distance
Authors: Maor Elad , Raphael Claire E. , Panaich Sidakpal S. , Reeder Guy S. , Nishimura Rick A. , Nkomo Vuyisile T. , Rihal Charanjit S. , Eleid Mackram F. 
Published: March 2017

Background—
Data on the clinical use of left atrial (LA) hemodynamic monitoring during MitraClip procedure are limited. This study evaluated the association between intraprocedural changes in LA pressure after MitraClip and improvement in exercise capacity as documented by 6-minute walk test (6MWT).

Methods and Results—

Study population included 50 patients who underwent MitraClip at the Mayo Clinic (Rochester, MN), between June 2014 and July 2016 and completed both baseline and 30-day follow-up 6MWT. Primary outcome for the current analysis was defined as 6MWT improvement above the median. Mean age of the study population was 79±10 years, and 34 (68%) were men. Baseline preprocedural 6MWT distance was 308 m (interquartile range [IQR], 234–394 m). Acute, intraprocedural change in LA pressure after MitraClip was 3 mm Hg (IQR, 1–6 mm Hg), and change in V wave was 11 mm Hg (IQR, 6–19 mm Hg). Median 6MWT improvement was 25 m (IQR, 19–47 m). Univariate analysis showed that patients with ≤ mild postprocedural mitral regurgitation were 4-fold more likely to experience an improvement in 6MWT (
P
=0.02). Multivariate model demonstrated that each 5 mm Hg decrease in V wave was associated with 49% increased likelihood for improvement in 6-minute walk (
P
=0.04). Similar model with V-wave change as a dichotomous variable showed that patients with a V-wave decrease of ≥11 mm Hg were 3.8× more likely to improve their 6MWT (
P
=0.05).

Conclusions—
Acute changes in LA pressure after MitraClip procedure are associated with clinical improvement as measured by 6MWT. Continuous LA pressure monitoring may be a useful tool for procedural guidance during transcatheter mitral repair.
Development and Psychometric Properties of a Scale to Measure Hospital Organizational Culture for Cardiovascular Care
Authors: Bradley Elizabeth H. , Brewster Amanda L. , Fosburgh Heather , Cherlin Emily J. , Curry Leslie A. 
Published: March 2017

Background—
Because organizational culture is increasingly understood as fundamental to achieving high performance in hospital and other healthcare settings, the ability to measure this nuanced concept empirically has gained importance. Aside from measures of patient safety culture, no measure of organizational culture has been widely endorsed in the medical literature, limiting replication of previous findings and broader use in interventional studies.

Methods and Results—
We sought to develop and assess the validity and reliability of a scale for assessing organizational culture in the context of hospitals’ efforts to reducing 30-day risk-standardized mortality after acute myocardial infarction. The 31-item scale was completed by 147 individuals representing 10 hospitals during August and September 2014. The resulting organizational culture scale demonstrated high level of construct validity and internal consistency. Factor analyses indicated that the 31 items loaded well (loading values 0.48–0.90), supporting distinguishable domains of (1) learning environment, (2) psychological safety, (3) commitment to the organization, (4) senior management support, and (5) time for improvement efforts. Cronbach α coefficients were 0.94 for the scale and ranged from 0.77 to 0.88 for the subscales. The scale displayed reasonable convergent validity and statistically significant variability across hospitals, with hospital identity accounting for 11.3% of variance in culture scores across respondents.

Conclusions—
We developed and validated a relatively easy-to-administer survey that was able to detect substantial variability in organizational culture across different hospitals and may be useful in measuring hospital culture and evaluating changes in culture over time as part performance improvement efforts.
Effect of 2013 ACC/AHA Blood Cholesterol Guidelines on Statin Treatment Patterns and Low‐Density Lipoprotein Cholesterol in Atherosclerotic Cardiovascular Disease Patients
Authors: Okerson Ted , Patel Jeetvan , DiMario Stefan , Burton Tanya , Seare Jerald , Harrison David J. 
Published: March 2017

Background
Preceding release of the 2013 American College of Cardiology (ACC)/American Heart Association (AHA) cholesterol guidelines, prescribers aimed for specific low‐density lipoprotein cholesterol (LDL‐C) goals in patients with atherosclerotic cardiovascular disease (ASCVD). The 2013 guidelines changed this focus to treating patients with appropriate statin intensity given their ASCVD risk. We examined statin use and LDL‐C levels before and after the 2013 ACC/AHA guidelines in patients with clinical ASCVD as defined in the guidelines.

Methods and Results

We conducted a retrospective cohort study of adult commercial and Medicare Advantage health plan enrollees in the Optum Research Database. Patients had ≥1 claim with a diagnosis of clinical ASCVD between November 1, 2012 and December 31, 2014 and were continuously enrolled 6 months before (baseline) and 7 months after (follow‐up) the first ASCVD visit. Patients were assigned to monthly cohorts based on ASCVD event month. Statin use and intensity were measured at baseline and first month of follow‐up. LDL‐C changes were assessed using ordinary least squares regression. For 90 287 patients, mean (SD) age was 68 (12) years; 50% were female; and 30% had commercial insurance. Statin use remained consistent before and after guidelines (32% and 31%, respectively). Of patients receiving statins, high‐intensity use increased by 4 percentage points 1 year after guidelines (
P
<0.001). Mean LDL‐C levels were 2.4 mmol/L (94 mg/dL) both pre‐ and postguidelines.

Conclusions
Statin use and mean monthly LDL‐C before and after the guidelines remained largely unchanged; statin intensity increased modestly. More effort may be needed to increase guideline understanding and adherence to improve treatment of high‐risk patients.
Characterization of Foci and Breakthrough Sites During Persistent and Long‐Standing Persistent Atrial Fibrillation in Patients: Studies Using High‐Density (510–512 Electrodes) Biatrial Epicardial Mapping
Authors: Lee Seungyup , Sahadevan Jayakumar , Khrestian Celeen M. , Markowitz Alan , Waldo Albert L. 
Published: March 2017

Background
We previously demonstrated that persistent and long‐standing persistent atrial fibrillation is maintained by activation emanating from foci and breakthrough sites of different cycle lengths (CLs). The purpose of this study was to characterize the behavior of focal and nonrandom breakthrough activation identified during high‐density mapping of atrial fibrillation in these patients.

Methods and Results
During open heart surgery, we recorded activation from both atria simultaneously using 510 to 512 epicardial electrodes along with ECG lead II in 12 patients with persistent and long‐standing persistent atrial fibrillation. For each patient, analysis of 32 consecutive seconds of activation from identified focal (sustained and/or intermittent) and nonrandom breakthrough sites was performed. Multiple foci (sustained and/or intermittent) of different CLs were present in both atria in 11 of 12 patients; 8 foci were sustained, and 22 were intermittent. Temporal CL behavior of sustained foci varied over time (≤20 ms of the mean CL). For intermittent foci, no activation periods were due to a spontaneous pause (18 of 22) or activation of the focus by another wave front (11 of 22). All patients had breakthrough activation. Seven patients had 12 nonrandom breakthrough sites. Periods of no breakthrough activation were caused by a spontaneous pause (6 of 12 patients) or activation from another wave front (4 of 12) or were uncertain (5 of 12). Focal and nonrandom breakthrough activation sometimes produced repetitive “wannabe” (incomplete) reentry in 6 of 12 patients.

Conclusions
During persistent and long‐standing persistent atrial fibrillation, sustained foci manifested variable CLs. Spontaneous pauses or activation from other wave fronts explained the intermittency of foci and nonrandom breakthrough. Focal and nonrandom breakthrough activation occasionally produced wannabe reentry.
Herpes Simplex Virus Laryngitis Presenting as Airway Obstruction: A Case Report and Literature Review
Authors: Harless Lucas , Jiang Nancy , Schneider Frank , Durr Megan 
Published: March 2017

Objectives: Herpes simplex virus (HSV) laryngitis is rare in adults. We add a case report to the literature and perform a literature review to further delineate the clinical presentation, course, and treatment of HSV laryngitis in adults. Methods: Case report and literature review using PubMed and Ovid databases. Results: Ten cases of diagnosed HSV laryngitis in adults were reported in the literature. It is more common in immunocompromised patients. The mean patient age was 51 years with a male to female ratio of 1:1. The clinical presentation and course of HSV laryngitis is variable. Patients may have mild chronic symptoms, such as dysphonia, or a fulminant course with rapid airway compromise. On laryngoscopic exam, the most common findings are a white exudate or ulceration. The most common treatment is with antiviral medication, such as acyclovir, which tends to be highly effective. Conclusions: Herpes simplex virus laryngitis is rare. Clinical presentation of HSV laryngitis is variable, and its course may be indolent or fulminant. Treatment with antiviral medication tends to be highly effective.
The Updating of the Cuban Model: Precursor Socialism and Cooperativism
Authors: Fuentes-Ramírez Ricardo R. 
Published: March 2017

Cuba can best be conceptualized as a precursor socialist social formation that has not necessarily begun a transition to capitalism. A case study of nonagricultural cooperatives demonstrates that the current reform process in Cuba has included features that could be foundational with respect to a new socialist formation characterized by participatory planning. Idealmente, Cuba se puede conceptualizar como una formación socialista precursora que no ha comenzado necesariamente una transición al capitalismo. Un estudio de caso de las cooperativas no-agropecuarias demuestra que el actual proceso de reforma en Cuba abarca características que podrían ser fundamentales a una nueva formación socialista caracterizada por la planificación participativa.
Fluoroscopy time is not accurate as a surrogate for radiation exposure
Authors: Skripochnik Edvard , Loh Shang A 
Published: March 2017

Objective The Food and Drug Administration and the Vascular Quality Initiative still utilize fluoroscopy time as a surrogate marker for procedural radiation exposure. This study demonstrates that fluoroscopy time does not accurately represent radiation exposure and that dose area product and air kerma are more appropriate measures. Methods Lower extremity endovascular interventions ( N = 145) between 2013 and 2015 performed at an academic medical center on a Siemens Artis-Zee floor mounted c-arm were identified. Data was collected from the summary sheet after every case. Scatter plots with Pearson correlation coefficients were created. A strong correlation was indicated by an r value approaching 1. Results Overall mean AK and DAP was 380.27 mGy and 4919.2 µGym2. There was a poor correlation between fluoroscopy time and total AK or DAP ( r = 0.27 and 0.32). Total DAP was strongly correlated to cine DAP and fluoroscopy DAP ( r = 0.92 vs. 0.84). The number of DSA runs and average frame rate did not affect AK or DAP levels. Mean magnification level was significantly correlated with total AK ( r = 0.53). Conclusions Fluoroscopy time shows minimal correlation with radiation delivered and therefore is a poor surrogate for radiation exposure during fluoroscopy procedures. DAP and AK are more suitable markers to accurately gauge radiation exposure.
Open Reduction Internal Fixation of Isolated Chondral Fragments Without Osseous Attachment in the Knee
Authors: Siparsky Patrick N. , Bailey James R. , Dale Kevin M. , Klement Mitchell R. , Taylor Dean C. 
Published: March 2017

Background: Isolated chondral fractures of the knee are a rare and challenging problem, typically occurring with an acute traumatic event such as dislocation of the patella or ligamentous injury. Historically, repair of unstable chondral fragments without osseous attachment has not been recommended due to concerns about the limited healing potential of cartilage. Purpose: To describe a technique for fixation of large isolated chondral fractures of the knee and present 3 cases where large chondral fragments without osseous attachment were fixed successfully with chondral darts and biologic adhesive. Study Design: Case series; Level of evidence, 4. Methods: The senior author reviewed his case logs for all patients on whom he performed open reduction and internal fixation on large isolated cartilage fragments without osseous attachment. Three were extracted from his review. The clinical and radiographic outcomes were retrospectively reviewed. Results: Successful results and complete healing was obtained in all 3 patients. This procedure can be done in the setting of concurrent injury, such as anterior cruciate ligament tear, using single- or multistaged chondral repair and ligament reconstruction techniques. Conclusion: Isolated chondral fragment repair techniques provide the orthopaedic surgeon an additional option for treating these challenging injuries. Primary fixation can be accomplished for what have been historically considered “unsalvageable” fragments.
Psychological and psychosocial interventions for negative symptoms in psychosis: Systematic review and meta-analysis
Authors: Lutgens Danyael , Gariepy Genevieve , Malla Ashok 
Published: March 2017

BackgroundNegative symptoms observed in patients with psychotic disorders undermine quality of life and functioning. Antipsychotic medications have a limited impact. Psychological and psychosocial interventions, with medication, are recommended. However, evidence for the effectiveness of specific non-biological interventions warrants detailed examination.AimsTo conduct a meta-analytic and systematic review of the literature on the effectiveness of non-biological treatments for negative symptoms in psychotic disorders.MethodWe searched for randomised controlled studies of psychological and psychosocial interventions in psychotic disorders that reported outcome on negative symptoms. Standardised mean differences (SMDs) in values of negative symptoms at the end of treatment were calculated across study domains as the main outcome measure.ResultsA total of 95 studies met our criteria and 72 had complete quantitative data. Compared with treatment as usual cognitive–behavioural therapy (pooled SMD −0.34, 95% CI −0.55 to −0.12), skills-based training (pooled SMD −0.44, 95% CI −0.77 to −0.10), exercise (pooled SMD −0.36, 95% CI −0.71 to −0.01), and music treatments (pooled SMD −0.58, 95% CI −0.82 to −0.33) provide significant benefit. Integrated treatment models are effective for early psychosis (SMD −0.38, 95% CI −0.53 to −0.22) as long as the patients remain in treatment. Overall quality of evidence was moderate with a high level of heterogeneity.ConclusionsSpecific psychological and psychosocial interventions have utility in ameliorating negative symptoms in psychosis and should be included in the treatment of negative symptoms. However, more effective treatments for negative symptoms need to be developed.