bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplicación de los principios de gobiernos corporativos a sociedades no cotizadas en Chile. Una aproximación desde el derecho societario europeo y comparado
Authors: Vásquez-Palma Maria Fernanda , Vidal-Olivares Álvaro 
Published: December 2017

<p>Dada la importancia que han adquirido los principios de buen gobierno corporativo (en adelante, PBGC), que rigen las sociedades que cotizan en bolsa y que operan como regla de conducta comercial y punto de referencia para el fortalecimiento de los mecanismos de control y supervisión de la administración de este tipo societario, este trabajo plantea la posibilidad de extensión de los PBGC a las sociedades que no cotizan en los mercados de valores, juntos a sus respectivos fundamentos.</p>
La responsabilidad del arrendador derivada de daños ambientales indirectos ocasionados por el arrendatario en Argentina
Authors: Ruiz Haraví Eloisa , Gapel-Redcozub Guillermo 
Published: December 2017

<p>Las transformaciones productivas ocurridas en las últimas décadas en el sector agropecuario argentino han impulsado una división entre la titularidad de la tierra y su explotación. Este desdoblamiento se instrumenta habitualmente mediante contratos de arrendamiento en los que los dueños transfieren el uso y goce del recurso a nuevas formas de organizaciones empresariales (pools de siembra). En un contexto en el que comienzan a multiplicarse los conflictos ambientales asociados a explotaciones rurales insustentables, el presente trabajo lleva adelante una investigación que tiene por objetivo reinterpretar los derechos y obligaciones de las partes del contrato de arrendamiento, con un enfoque particular en los deberes ambientales del arrendador. Con base en el bloque normativo integrado por la Constitución Nacional, la Ley General del<br />Ambiente y el Código Civil y Comercial, concluimos que el arrendador está sometido a un verdadero deber de control sobre las actividades que se desarrollan sobre su propiedad, y que en caso de incumplimiento de este deber y frente a daños ambientales indirectos, podrá ser tenido por responsable y obligado a costear las reparaciones correspondientes. </p>
All-cause mortality and major cardiovascular outcomes comparing percutaneous coronary angioplasty versus coronary artery bypass grafting in the treatment of unprotected left main stenosis: a meta-analysis of short-term and long-term randomised trials
Authors: Laukkanen Jari A , Kunutsor Setor K , Niemelä Matti , Kervinen Kari , Thuesen Leif , Mäkikallio Timo H 
Published: December 2017

ObjectiveWe compared percutaneous coronary intervention (PCI) with coronary artery bypass grafting (CABG) for the treatment of left main coronary artery (LMCA) disease by conducting a systematic review and meta-analysis of randomised controlled trials (RCTs).MethodsRCTs of PCI versus CABG in patients with LMCA stenosis were identified from MEDLINE, the Cochrane Library and search of bibliographies to November 2016. Study-specific HRs with 95% CIs were aggregated for all-cause mortality, major adverse cardiac and cerebrovascular events (MACCE), and other cardiovascular events at time points of 30 days, 1 year and 3 years and beyond.ResultsSix RCTs comprising 4700 patients were included. There were no significant differences in risk of all-cause mortality in pooled analysis of relevant trials at 30 days (0.61, 95% CI 0.27 to 1.36), 1 year (0.66, 95% CI 0.42 to 1.04), and 3 years and beyond (1.04, 95% CI 0.81 to 1.33), comparing PCI with CABG. There was no significant difference in the risk of MACCE at 30 days (0.72, 95% CI 0.51 to 1.03) and 1 year (1.16, 95% CI 0.94 to 1.44); however, PCI was associated with a higher risk of MACCE compared with CABG during longer-term follow-up (1.27, 95% CI 1.12 to 1.44). Composite outcome of death, stroke or myocardial infarction was lower with PCI at 30 days (0.67, 95% CI 0.49 to 0.92). Repeat revascularisation was increased at 1 year and at 3 years and beyond for PCI.ConclusionsAll-cause mortality rates are not significantly different between PCI and CABG at short-term and long-term follow-up. However, PCI is associated with a reduction in the risk of major cardiovascular outcomes at short-term follow-up in patients with LMCA stenosis; but at long term, MACCE rate is increased for PCI.
Mathematical aspects of Bose–Einstein condensation in equilibrium and local equilibrium conditions
Authors: Accardi Luigi , Pandiscia Carlo 
Published: December 2017

In the paper4 the notion of local KMS condition, introduced in Ref. 3 and extended in Ref. 2, was shown to open new possibilities in the study of the problem of Bose–Einstein Condensation (BEC). In this paper we analyze the general structure of states on the CCR algebra over a pre-Hilbert space that satisfies the local KMS condition with respect to a free Hamiltonian [Formula: see text] and to a given inverse temperature function [Formula: see text]. The replacement of Hilbert space by a pre-Hilbert space allows one to deal with test functions more singular than those usually considered in the theory of distributions (thus allowing e.g., fractal critical surfaces) and is equivalent (in the language of Weyl algebras) to consider a degenerate symplectic form. It is precisely this degeneracy that allows one to introduce in an intrinsic way the notions of [Formula: see text]-critical subspace (resp. [Formula: see text]-critical surface) and of states exhibiting BEC, independently of infinite volume limits and of boundary conditions. We prove that the covariance of any local KMS state is uniquely determined by the pair [Formula: see text], through a nonlinear extension of the Planck factor. For a large class of such states (including all known examples) the covariance splits into a sum of two mutually singular terms: one corresponding to a regular state, the other one with support on a critical surface (or more generally a critical subspace) uniquely determined by [Formula: see text] and [Formula: see text]. In particular we prove that, if such a state is gauge invariant Gaussian (quasi-free), then the [Formula: see text]-equilibrium condition uniquely determines the regular part of the state, while the singular part is arbitrary.
Autologous Dendritic Cells Pulsed with Allogeneic Tumor Cell Lysate in Mesothelioma: From Mouse to Human
Authors: Aerts Joachim G.J.V. , de Goeje Pauline L. , Cornelissen Robin , Kaijen-Lambers Margaretha E.H. , Bezemer Koen , van der Leest Cor H. , Mahaweni Niken M. , Kunert André , Eskens Ferry A.L.M. , Waasdorp Cynthia , Braakman Eric , van der Holt Bronno , Vulto Arnold G. , Hendriks Rudi W. , Hegmans Joost P.J.J. , Hoogsteden Henk C. 
Published: December 2017

Abstract
Purpose: Mesothelioma has been regarded as a nonimmunogenic tumor, which is also shown by the low response rates to treatments targeting the PD-1/PD-L1 axis. Previously, we demonstrated that autologous tumor lysate–pulsed dendritic cell (DC) immunotherapy increased T-cell response toward malignant mesothelioma. However, the use of autologous tumor material hampers implementation in large clinical trials, which might be overcome by using allogeneic tumor cell lines as tumor antigen source. The purpose of this study was to investigate whether allogeneic lysate–pulsed DC immunotherapy is effective in mice and safe in humans.
Experimental Design: First, in two murine mesothelioma models, mice were treated with autologous DCs pulsed with either autologous or allogeneic tumor lysate or injected with PBS (negative control). Survival and tumor-directed T-cell responses of these mice were monitored. Results were taken forward in a first-in-human clinical trial, in which 9 patients were treated with 10, 25, or 50 million DCs per vaccination. DC vaccination consisted of autologous monocyte–derived DCs pulsed with tumor lysate from five mesothelioma cell lines.
Results: In mice, allogeneic lysate–pulsed DC immunotherapy induced tumor-specific T cells and led to an increased survival, to a similar extent as DC immunotherapy with autologous tumor lysate. In the first-in-human clinical trial, no dose-limiting toxicities were established and radiographic responses were observed. Median PFS was 8.8 months [95% confidence interval (CI), 4.1–20.3] and median OS not reached (median follow-up = 22.8 months).
Conclusions: DC immunotherapy with allogeneic tumor lysate is effective in mice and safe and feasible in humans. Clin Cancer Res; 24(4); 766–76. ©2017 AACR.
Estudos de elites políticas e as bases das multinotabilidades no Brasil
Authors: Reis Eliana Tavares dos , Grill Igor Gastal 
Published: December 2017

Este artigo discute três bases de multinotabilização das elites políticas (a familiar; a militante e profissional; a produção de bens simbólicos) e como se traduzem em trunfos mobilizáveis nas lutas políticas no Brasil. Mediante reflexão indissociavelmente analítica e empírica, propomos que a apreensão das multidimensionalidades e das intersecções entre domínios e práticas potencializa a investigação extensiva e intensiva dos princípios de funcionamento, de seleção e de hierarquização políticas, dos condicionantes e lógicas de atuação dos agentes, bem como dos processos de legitimação que incidem na composição dos profissionais da representação
Sindicalismo e neodesenvolvimentismo: analisando as greves entre 2003 e 2013 no Brasil
Authors: Marcelino Paula 
Published: December 2017

Neste artigo, apresentaremos uma análise sobre as greves que aconteceram no Brasil no período dos governos do Partido dos Trabalhadores: de 2003, primeiro ano do primeiro mandato de Lula da Silva, até 2013, penúltimo ano do primeiro mandato de Dilma Rousseff na presidência da República. Ainda que tendo como foco esses dez anos, buscaremos, ao final, refletir sobre os dados posteriores para procurar identificar quais movimentos estão se desenhando para o sindicalismo brasileiro no período subsequente. As greves serão analisadas tendo em consideração os seguintes aspectos: frequência e duração das paralisações, as motivações, os encaminhamentos e os resultados desses conflitos. Ao longo do texto trataremos de explicar por que entendemos que essas greves reforçam a tese da existência de um período neodesenvolvimentista no Brasil e refletem as características da configuração específica da luta de classes do período. Os principais dados que utilizaremos foram coletados e sistematizados pelo Departamento Intersindical deEstatísticas e Estudos Socioeconômicos (Dieese)
Espaço social e redes: contribuições metodológicas à sociologia das elites
Authors: Klüger Elisa 
Published: December 2017

O artigo apresenta uma contribuição metodológica à sociologia das elites, ao focar a conciliação de desenhos de redes sociais com construções de representações geométricas de espaços sociais, com auxílio da análise de correspondências múltiplas. Após discutir aspectos para a convergência das metodologias, comenta-se trabalhos que posicionam as propriedades sociais nas redes ou que desenham laços nos espaços sociais. Finalmente, indica-se que tal aproximação poderia dotar a sociologia das elites de acuidade para testar se há maior probabilidade de aproximação entre agentes que possuem habitus afinados, para operacionalizar a noção de capital social e para compreender em termos estruturais e relacionais processos de cooptação e coligação de membros das frações dominantes, tais como casamentos, clubes, eleição de sucessores e formação de alianças profissionais e políticas
“The Sagacity of the Indians”: William Dampier’s Surprising Respect for Indigenous Knowledge
Authors: Irving-Stonebraker Sarah 
Published: December 2017

Abstract
English privateer and amateur ethnographer William Dampier’s work abounds with admiring descriptions of the knowledge and skills of the indigenous societies he encountered on his global voyages. These positive descriptions of indigenous culture make a surprising juxtaposition against the tenor of ethnography little more than a century later, when biological theories of race grounded disparaging attitudes toward indigenous cultures. This article explores the conditions of possibility of a historical moment during the late seventeenth and early eighteenth-century Anglophone world, in which it was possible to acknowledge some of the merits of indigenous knowledge. I argue that it was the framework of Baconian natural history, with its focus on useful knowledge, and its methodological emphasis on empirical data rather than theorizing, which made it possible for Dampier to treat indigenous societies not only as the objects of knowledge, but more importantly, as sources of knowledge.
The Inquisition Tribunal in Goa: Why and for What Purpose?
Authors: Paiva José Pedro 
Published: December 2017

Abstract
This article aims to explain the process which led to the founding of the Inquisition tribunal in Goa, the first Holy Office tribunal to be created outside Europe. Following a review of previous historiographical studies which have analyzed this question, it examines the mechanisms for Christianization/confessionalization deployed by the Iberian monarchs in Asia and America from a global and comparative perspective, based on a rereading and reinterpretation of Inquisition documents and correspondence from various agents who were involved in the process. It presents an explanation that emphasizes the existence of a cluster of causalities which created a dense network of convergent forces that favored the founding of an Inquisition tribunal in Asia in 1560.
The Molnár Debate of 1950: Hungarian Communist Historical Politics and the Problem of the Soviet Model
Authors: Litkei József 
Published: December 2017

By tracing the developments that led to a historical debate in 1950, this article questions some assumptions concerning the Stalinization of Hungarian history writing, in particular the notion of a predetermined continuity between the national-communist line followed by Hungarian communists before and after 1949. Contrary to the understanding of the Sovietization of historiography in Hungary as a straightforward process, guided by a firmly-established ideological line, this article shows that the period between early 1949 and 1950 was characterized by a certain level of uncertainty, caused, on the one hand, by the ideological and institutional changes brought about by Sovietization, and, on the other, by a temporary lack of firm interpretative guidance from the Party leadership. A closer look into the efforts to elaborate a new periodization of Hungarian history reveals not only the existence of competing Marxist interpretations (a “national” state-oriented and an “internationalist” one with a focus on socioeconomic phenomena), but also that for a while it was unclear which of them would emerge as the basis of the Stalinist canon. Although the question was ultimately settled by a political intervention in favor of the more national line, the Hungarian case shows that it was far from evident what the Soviet model was supposed to mean when transferred to local contexts—and that adaptation depended on numerous factors, the ambitions of the interpreters being one of them. This contingency, and the relative plurality of “useable pasts”—which is also reflected in the lack of uniformity in the ways Soviet Bloc regimes treated their respective national histories—cautions against treating the historical representations these regimes produced as self-explanatory outcomes of Stalinization: the examination of the dilemmas that marked the process of creating these canons should be given just as much consideration as the analysis of the end products themselves.
The Massachusetts School Sports Concussions Law: A Qualitative Study of Local Implementation Experiences
Authors: Doucette Mitchell L. , Bulzacchelli Maria T. , Gillum Tameka L. , Whitehill Jennifer M. 
Published: December 2017

Background:Reducing the incidence and negative consequences of concussion among youth athletes is a public health priority. In 2010, Massachusetts passed legislation aimed at addressing the issue of concussions in school athletics. We sought to understand local-level implementation decisions of the Massachusetts concussion law.Methods:A qualitative multiple-case study approach was utilized. Semi-structured interviews with school-employed actors associated with the law's implementation were used for analysis. Interview data were subjected to a conventional content analysis.Results:A total of 19 participants from 5 schools were interviewed. Schools were purposefully selected from communities varying in socioeconomic status and population. Participants included 5 athletic directors, 5 coaches, 4 athletic trainers, 4 school nurses, and 1 health and wellness coordinator. Eight themes emerged regarding specific ways schools have implemented the law. Six themes emerged regarding factors influencing implementation.Conclusions:All cases employ neurocognitive testing as a means to assess concussions, place decision-making authority in athletic trainers' hands, and use a 30-minute online video to disseminate concussion education. Employing athletic trainers could pose challenges to school districts with limited financial capacity, as financial assistance from the state is not provided under the law. The validity of neurocognitive testing and the effectiveness of online concussion training need further study. Cooperation from student athletes, their parents, and physicians is necessary for full implementation of the law.
The diagnosis and management of nerve injury during endodontic treatment
Authors: Rosen Eyal 
Published: December 2017

Abstract

Background
Nerve injury and an ensuing altered sensation following endodontic treatment is an infrequent and severe complication, which may lead to longstanding disability and may have substantial adverse effects on the patient’s quality of life. This review is aimed at providing the practitioner with the knowledge and useful means to diagnose and manage nerve injury when performing endodontic treatments.

Conclusion
Vigorous preventive measures and a timely mannered management approach are the most proficient measures to reduce the risk of endodontic treatment related nerve injuries and to prevent long-lasting impairment. The diagnosis of a nerve injury requires a combination of a thorough anamnesis, a proper clinical evaluation, and an adjunct radiographic evaluation when indicated. Early intervention by the prescription of anti-inflammatory drugs may be beneficial. In certain persistent cases, modern endodontic surgery may enable a minimally invasive and highly accurate surgical procedure, and with adequate case selection, may provide a predictable outcome and allow the preservation of the tooth.
HALO 202: Randomized Phase II Study of PEGPH20 Plus Nab-Paclitaxel/Gemcitabine Versus Nab-Paclitaxel/Gemcitabine in Patients With Untreated, Metastatic Pancreatic Ductal Adenocarcinoma
Authors: Hingorani Sunil R. , Zheng Lei , Bullock Andrea J. , Seery Tara E. , Harris William P. , Sigal Darren S. , Braiteh Fadi , Ritch Paul S. , Zalupski Mark M. , Bahary Nathan , Oberstein Paul E. , Wang-Gillam Andrea , Wu Wilson , Chondros Dimitrios , Jiang Ping , Khelifa Sihem , Pu Jie , Aldrich Carrie , Hendifar Andrew E. 
Published: December 2017

Purpose Metastatic pancreatic ductal adenocarcinoma is characterized by excessive hyaluronan (HA) accumulation in the tumor microenvironment, elevating interstitial pressure and impairing perfusion. Preclinical studies demonstrated pegvorhyaluronidase alfa (PEGPH20) degrades HA, thereby increasing drug delivery. Patients and Methods Patients with previously untreated metastatic pancreatic ductal adenocarcinoma were randomly assigned to treatment with PEGPH20 plus nab-paclitaxel/gemcitabine (PAG) or nab-paclitaxel/gemcitabine (AG). Tumor HA levels were measured retrospectively using a novel affinity histochemistry assay. Primary end points were progression-free survival (PFS; overall) and thromboembolic (TE) event rate. Secondary end points included overall survival, PFS by HA level, and objective response rate. An early imbalance in TE events in the PAG arm led to a clinical hold; thereafter, patients with TE events were excluded and enoxaparin prophylaxis was initiated. Results A total of 279 patients were randomly assigned; 246 had HA data; 231 were evaluable for efficacy; 84 (34%) had HA-high tumors (ie, extracellular matrix HA staining ≥ 50% of tumor surface at any intensity). PFS was significantly improved with PAG treatment overall (hazard ratio [HR], 0.73; 95% CI, 0.53 to 1.00; P = .049) and for patients with HA-high tumors (HR, 0.51; 95% CI, 0.26 to 1.00; P = .048). In patients with HA-high tumors (PAG v AG), the objective response rate was 45% versus 31%, and median overall survival was 11.5 versus 8.5 months (HR, 0.96; 95% CI, 0.57 to 1.61). The most common treatment-related grade 3/4 adverse events with significant differences between arms (PAG v AG) included muscle spasms (13% v 1%), neutropenia (29% v 18%), and myalgia (5% v 0%). TE events were comparable after enoxaparin initiation (14% PAG v 10% AG). Conclusion This study met its primary end points of PFS and TE event rate. The largest improvement in PFS was observed in patients with HA-high tumors who received PAG. A similar TE event rate was observed between the treatment groups in stage 2 of the trial.
A atividade discursiva realizada no Facebook: um emergente gênero discursivo hipertextual
Authors: Tedesco V. Abreu Maria Teresa , Normandia Cristina 
Published: December 2017

La red social Facebook es un sitio popular muy utilizado para el entretenimiento y también para las interacciones de información. Así se percibe, principalmente en los comentarios publicados en el sitio, un «intercambio» de puntos de vista sobre temas diversos, que van desde un subjetivo comentario sobre una foto hasta el posicionamiento crítico sobre hechos que forman parte al contexto social y político.Este intercambio legitima el popular sitio como ambiente libre para la expresión de la opinión. Se pregunta: ¿Facebook es un género discursivo? Para contestar a la cuestión, este artículo analiza la secuencia textual de comentarios publicados en Facebook, específicamente en un perfil personal. Se propone discutir sobre el proceso de comprensión y de producción textual en comentarios publicados en el ambiente social de Facebook, considerando puntualmente dos fenómenos lingüístico–discursivos: la intertextualidad y la referenciación, responsables de la (re)construcción de sentidos en el texto (Koch, 2002, 2014). Teóricamente respaldado en la lengua como lugar de interacción, el primero está asociado al conocimiento de mundo del sujeto enunciador; el segundo, al conocimiento lingüístico. El análisis indica el sitio popular como un provechoso lugar de interacción.