bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 Omicron XBB infections boost cross-variant neutralizing antibodies, potentially explaining the observed delay of the JN.1 wave in some Brazilian regions
Authors: Lopez Tort Luis Fernando , de Araújo Mia Ferreira , Arantes Ighor , Martins Jéssica SCC , Gomes Marcelo , de Carvalho Felipe Cotrim , Ferreira de Almeida Walquiria Aparecida , Caetano Braulia Costa , Appolinario Luciana R. , Pereira Elisa Calvalcante , Carvalho Jéssica , Miyajima Fábio , Wallau Gabriel Luz , Naveca Felipe Gomes , Alves Pedro , Espíndola Otávio , Brasil Patricia , Resende Paola Cristina , Bello Gonzalo , Siqueira Marilda Mendonça 
Published: September 2024

AbstractObjectivesThe SARS-CoV-2 JN.1 lineage emerged in late 2023 and quickly replaced the XBB lineages, becoming the predominant Omicron variant worldwide in 2024. We estimate the epidemiological impact of this SARS-CoV-2 lineage replacement in Brazil and we further assessed the cross-reactive neutralizing antibody (NAb) responses in a cohort of convalescent Brazilian patients infected during 2023.MethodsWe analyzed the evolution of SARS-CoV-2 lineages and severe acute respiratory infection (SARI) cases in Brazil between July 2023 and March 2024. We evaluated the cross-reactive NAb responses to the JN.1 variant in a cohort of convalescent Brazilian patients, both before and after infection with XBB.1* lineages.ResultsJN.1 replaced XBB with similar temporal dynamics across all country regions, though its epidemiological impact varied between locations. The Southeastern, Southern, and Central-Western regions experienced a brief XBB wave around October 2023, shortly before the introduction of JN.1, without any immediate upsurge of SARI cases during viral lineage replacement. By contrast, the Northeastern and Northern regions did not experience an XBB wave in the latter half of 2023 and displayed a rapid surge in SARI cases driven by the emergence of the JN.1. We found that recent XBB infections in the Brazilian population significantly boosted cross-reactive NAb levels against JN.1.ConclusionsThe XBB wave observed in the second half of 2023 in some Brazilian states likely acted as a booster for population immunity, providing short-term protection against JN.1 infections and delaying the rise of SARI cases in certain regions of the country.
Transplantation and old stem cell age independently increase the risk of clonal hematopoiesis in long-term survivors of pediatric HCT
Authors: Müskens K.F. , Wieringa N. , van Bergen M. , Bense J.E. , Pas B.M. te , de Pagter A.P.J. , Lankester A.C. , Bierings M.B. , Neuberg D. , Haitjema S. , Kremer L.C.M. , Huls G.A. , Nierkens S. , Jansen J.H. , Lindemans C.A. , de Graaf A. , Belderbos M.E. 
Published: September 2024

AbstractIn pediatric hematopoietic cell transplantation (HCT) recipients, transplanted donor cells may need to function far beyond normal human lifespan. Here, we investigated the risk of clonal hematopoiesis (CH) in 144 pediatric long-term HCT survivors, compared to 115 healthy controls. CH was detected in 16% of HCT survivors, at variant allele frequencies (VAFs) of 0.01-0.31. Mutations were predominantly in DNMT3A (80%) and TET2 (20%). Older stem cell age and the HCT procedure independently increased the risk of CH (odds ratios 1.07 per year increase (p<0.001) and 2.61 for HCT (p=0.02)), indicating both aging- and transplantation-induced effects. Large clones (VAF >0.10) were found exclusively in HCT recipients. Notably, CH was also detected within 15 years after cord blood HCT. Inflammatory processes around graft infusion were associated with CH presence. Future studies are required to track the evolution of post-transplant CH and its impact on future cardiovascular disease, second malignancies and overall survival.Significance statementAs the number of long-term HCT survivors continues to increase, so does the population at risk of long-term effects. We demonstrate that pediatric HCT survivors are at increased risk of clonal hematopoiesis compared to the general population. Given the young age of these recipients, our data emphasize the need for prospective studies to assess the potential health consequences of post-transplant CH.
Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration
Authors: Borbinha Jorge , Lourenço Raquel , Brandão Ana S. , Carvalho Ana , Matthiesen Rune , Jacinto António 
Published: September 2024

AbstractTissue regeneration relies on precise molecular mechanisms controlling cell fate transitions, with cell metabolism emerging as a key regulator. Lactate-derived histone lactylation has recently been identified as an important epigenetic modification involved in the regulation of gene expression across various biological processes. In this study, we report an increase in global histone lactylation and H3K18Lac levels in the mesenchyme and osteoblasts of the zebrafish caudal fin, during the early stages of regeneration. Our findings demonstrate that this epigenetic modification is functionally regulated by increased lactate levels, while inhibition of glycolysis and lactate production significantly reduces histone lactylation. These results suggest that metabolic reprogramming, in response to caudal fin injury, regulates histone lactylation, potentially modulating gene expression essential for cell plasticity and proliferation. This study expands our understanding of how metabolic-epigenetic interactions influence regenerative processes, providing valuable insights for the development of novel therapeutic strategies to enhance tissue repair.Summary statementLactate-derived histone lactylation plays a role in the early stages of zebrafish caudal fin regeneration, coupling metabolic adaptation with tissue repair mechanisms, through epigenetic regulation.
Phage Steering in the Presence of a Competing Bacterial Pathogen
Authors: Czerwinski Sean M. , Gurney James 
Published: September 2024

AbstractThe rise of antibiotic-resistant bacteria has necessitated the development of alternative therapeutic strategies such as bacteriophage therapy, where viruses specifically infect bacteria. However, rapid bacterial resistance to phage treatment remains a critical challenge, often leading to failure. Phage steering, which leverages the co-evolutionary dynamics between phage and bacteria, offers a novel solution by driving bacteria to evolve away from virulence factors or resistance mechanisms. In this study, we examined whether phage steering using bacteriophage Luz19 could function in the presence of a competing pathogen,Staphylococcus aureus(USA300), while targetingPseudomonas aeruginosa(PAO1). Throughin vitroco-evolution experiments with and without the competitor, we observed that Luz19 consistently steeredP. aeruginosaaway from the Type IV Pilus (T4P), a key virulence factor, without interference fromS. aureus. Genomic analyses revealed mutations in T4P-associated genes, includingpilRandpilZ, which conferred phage resistance. Our findings suggest that Phage Steering remains effective even in polymicrobial environments, providing a promising avenue for enhancing bacteriophage therapy efficacy in complex infections.
Etiological Factors ofRisk for Occupational Illnessin Nursing Professionals: Etiology and Risk Review Protocol
Authors: da Silva Cyntia Leenara Bezerra , Dantas Ana Clara , Coutinho Borges Bárbara Ebilizarda , de Carvalho Leandro Melo , Nascimento Heloise Rosália de Carvalho , de Souza Maria Clara Regis , Vitor Allyne Fortes 
Published: September 2024

AbstractAimTo describe the protocol for a systematic review of etiology and risk to identify the etiological factors ofRisk for Occupational Illnessin nursing professionals.DesignEtiology and risk review protocol, conducted according to JBI guidelines.MethodsThis is an etiology and risk review protocol to be carried out following the JBI guidelines in the following data sources: CINAHL, MEDLINE/PubMed, Cochrane Library, Scopus, EMBASE, Latin American and Caribbean Literature in Health Sciences, National Institute of Security and Health at Work and National Institute of Health at Work. The inclusion criteria are studies that address workers aged 18 years until retirement, demonstrate etiological factors that condition the susceptibility of the ND in question and address analyses regarding the identification, definition and association of factors with theRisk of Occupational Illness. The exclusion criteria are studies that did not address the topic, opinion articles, letters to the editor and editorials.Expected ResultsThe results of this review will be publicly disclosed in scientific journals in the health area and will contribute to increasing the level of evidence of the Nursing DiagnosisRisk for Occupational Illness, so that they remain in future editions of NANDA International and that the diagnosis is updated and revised based on the current scientific literature.ConclusionIt is expected identify the possible uses of the concept; determine the essential critical attributes; identify the antecedents and consequences of the concept; and define the empirical references and to highlight the etiological factors that are consistent with susceptibility to occupational illness.Strengths and limitations of this studyThis study will review the scientific literature on the etiological factors ofRisk for Occupational Illnessin nursing professionals, providing an increase in the level of evidence for this Diagnosis;The steps of this review will be followed strictly in accordance with the criteria of the JBI Manual for Evidence Synthesis;To avoid selection bias, data collection will occur independently with active blinding of researchers, who will use software to export and select data.
Bacterial motility patterns adapt smoothly in response to spatial confinement and disorder
Authors: Zhang Haibei , Wetherington Miles T. , Ko Hungtang , FitzGerald Cody E. , Munro Edwin M. , Nirody Jasmine A. 
Published: September 2024

AbstractRecent studies have shown thatEscherichia coliin highly confined porous media exhibit extended periods of ‘trapping’ punctuated by forward ‘hops’, a significant restructuring of the classical run- and-tumble model of motility. However, bacterial species must navigate a diverse range of complex habitats, such as biological tissues, soil, and sediments. These natural environments display varying levels of both (1) packing density (i.e., confinement) and (2) packing structure (i.e., disorder). Here, we introduce a microfluidic device that enables precise tuning of these environmental parameters, allowing for a more systematic exploration of bacterial motility bridging the extremes of unconfined and highly confined conditions. We observe that motility patterns characteristic of both hop-and-trap and run-and-tumble models coexist in nearly all environments tested, with ensemble dynamics transitioning between these behaviors as both confinement and disorder increase. We demonstrate that dynamics expected from the hop-and-trap model emerge naturally from a modified run-and- tumble model under specific environmental constraints. Our results suggest that bacterial motility patterns lie along a continuum, rather than being confined to a small set of discrete locomotive modes.
The impact of perceived experience with ChatGPT on online consumers' information searching behavior: an empirical study of Iranian college students
Authors: Alizadeh Hamid , Nazarpour Kashani Hamed 
Published: September 2024

PurposeThe purpose of this study is to explore the impact of perceived experience with ChatGPT on online consumers' information searching behavior. The study also examines the moderating effects of those relationships.Design/methodology/approachPrimary data were collected through an online survey. In total, 370 eligible responses were received. This study applied partial least squares structural equation modeling (PLS-SEM) for data analysis.FindingsThe findings demonstrate that both perceived personalization and perceived relevance have a direct impact on online consumers' information searching behaviors. Additionally, the results also indicate that perceived accuracy and perceived convenience lead to positive online consumers' information searching behavior. Moreover, age and gender and education level play moderating mechanisms in this relationship.Practical implicationsOverall, the conclusions of this study provide valuable insights into the potential of ChatGPT to improve online consumers behavior. However, there are still many unanswered questions about the impact of ChatGPT on consumers' experience. Future research is needed to explore these questions and to further our understanding of the potential of ChatGPT to revolutionize online information searching and digital marketing.Originality/valueTo the best of the authors’ knowledge, this paper is the first of its kind to highlight the impact of perceived experience with ChatGPT on online consumers' information searching behavior of its extensive use in scientific research and academic work. The importance of this study lies in the fact that it presents the behaviors concerns and future fears of people in academia as they cope with and deal with the inevitable reality of artificial intelligence (AI) language models such as ChatGPT.
Towards sustainable living: an investigation of the motivations behind green residential ownership in Malaysia
Authors: Chuweni Nor Nazihah , Mohamed Saraf Mohamad Haizam , Fauzi Nurul Sahida , Ahmad Mohamed Nurulanis 
Published: September 2024

Purpose
In recent years, there has been a significant increase in the number of green residential properties. This phenomenon indicates that the demand for environmentally friendly residential properties is rising. However, the true reasons behind the growing interest and investment in green residential properties remain poorly understood. When it comes to residential properties, assessing these benefits becomes more challenging and complex, as it is crucial to understand the motivations to invest in green residential properties. Therefore, the purpose of this study is to identify the component factors that motivate homebuyers to invest in green residential properties.

Design/methodology/approach
This research aims to address a research gap by identifying the component factors that motivate individuals to invest in green residential properties using a factor analysis approach. The authors gathered data by distributing an online questionnaire among 161 certified green residential owners in Selangor, Malaysia.

Findings
The results from the factor analysis revealed three components as the primary factors that motivate individuals to invest in green residential properties. The findings contribute significantly to the growing yet limited literature in this area of research.

Research limitations/implications
This research, however, set out to provide a context-specific motivation in Selangor as a limitation.

Originality/value
By understanding the motivations behind these investments, the research can encourage greater adoption of sustainable housing investment and guide developers and policymakers in offering better solutions for the green property market. The authors could facilitate informed decision-making and inspire positive change towards a future where sustainable housing becomes the norm.
Blockchain-enabled traceability systems for supply chain quality management: empirical insights from pharmaceutical manufacturers
Authors: Sahoo Saumyaranjan 
Published: September 2024

PurposeThe emergence of blockchain technology has the potential to bring about transformative changes in various industries, with supply chain management being a prominent domain of application. This study investigates the strategic performance benefits of using blockchain-enabled traceability systems for improving supply chain quality management.Design/methodology/approachThe present study employed structural equation modelling to analyse data obtained from 200 practitioners working in Indian pharmaceutical companies.FindingsThe results reflect that blockchain-enabled traceability systems have a positive impact on multi-tier quality governance (MQG); supply chain process alignment and coordination (SPAC) and quality centric collaboration (QCC); all of which are the facets of supply chain quality management. Furthermore, when examining the impact of blockchain-enabled traceability systems on firm quality performance and economic performance, the mediation role of SPAC and QCC was confirmed, whereas the mediation role of MQG could not be established.Practical implicationsThe study’s empirical insights offer practical guidance for pharmaceutical manufacturers, regulators and other industry participants seeking to harness the potential of blockchain technology for creating resilient and transparent supply chains that uphold product quality and safety standards.Originality/valueThese findings underscore the significance of blockchain-enabled traceability systems in revolutionizing supply chain quality management practices to achieve superior strategic performance in the pharmaceutical sector.
Exploring opportunities for language immersion in the posthuman spectrum: lessons learned from digital agents
Authors: Lotherington Heather , Pegrum Mark , Thumlert Kurt , Tomin Brittany , Boreland Taylor , Pobuda Tanya 
Published: September 2024

Purpose
Technologically-enhanced language education has shifted from computer-assisted language learning (CALL) to mobile-assisted language learning (MALL), including the use of conversational digital agents, and more recently, towards the use of generative artificial intelligence (AI) large language model (LLM) programmes for language learning purposes. This paper aims to explore the interplay between such posthuman communication and posthumanist applied linguistics, and between digital agents and human agency in response to the increasing permeation of AI in life and learning.

Design/methodology/approach
A core team of four researchers investigated how digital agents could be leveraged to support immersive target language learning and practice, focusing specifically on the conversational AI that pervaded digitally-mediated communication prior to the release of generative AI. Each researcher engaged in a digital autoethnography using conversational agents found in the digital wilds to learn a target second language via digital immersion.

Findings
Through qualitative data analysis of autoethnographic narratives using NVIVO, four key thematic codes characterizing the learning journeys emerged: context, language learning, posthuman engagement and technological parameters. The posthuman learning experiences conflicted with the multisensory, embodied and embedded ethos of posthumanist applied linguistics, indicating that informed human pedagogical agency must crucially be exercised to benefit from the learning potential of posthuman agents. Interactions with conversational agents did provide small-scale, just-in-time learning opportunities, but these fell short of immersive learning.

Originality/value
The methodology and findings offer a unique and valuable lens on the language learning potential of emerging LLM-based generative agents that are rapidly infusing conversational practices.
Indigenous knowledge for climate action at the Ekyisalhalha kya Karoro sacred site, adjacent to Rwenzori mountains national park in Kasese
Authors: Nsibambi Fredrick , Akiiki Aliguma Ahabyona 
Published: September 2024

PurposeThis case study examines the contribution of Indigenous knowledge (IK) and practices to climate action at Ekisalhalha kya Kororo sacred site, adjacent to Rwenzori Mountains National Park in the Kasese district of Western Uganda. This paper is intended to make a case for IK as an important component of climate change mitigation strategies especially if the knowledge is profiled and publicised. The paper presents aspects of traditional knowledge in terms of ceremonies, rituals, norms and customs that can be re-energised for climate change.Design/methodology/approachThe authors employed mainly a participatory and qualitative data collection methodology. The data were collected in Kasese district largely from the local government officials, cultural leaders, civil society actors and representatives of indigenous minority communities such as the Basongora. Data were collected from both primary and secondary sources, at the desk and through community interactions to collect various narratives based on IK. Primary data were collected during individual interviews, by administering a semi-structured questionnaire and holding focus group discussions with different stakeholders in Kasese, Uganda. The respondents were carefully identified and included cultural leaders, young people, local government authorities and representatives of civil society organisations responsible for implementing climate change mitigation strategies.FindingsClimate change effects are manifest in rising temperatures, flooding, desertification and other natural hazards. The Kasese district, in particular, has faced several climatic change catastrophes and there has been limited use or mainstreaming of the existing IK of the communities in the region in different climate action interventions. Amongst the key research findings was that IK can be utilised to address or mitigate climate change risks/hazards and provide valuable insights into climate adaptation strategies, including rain-water harvesting, weather forecasting and preparedness, and sustainable farming practices. In addition, it is easily accessible, especially in areas that modern science has not reached.Research limitations/implicationsFew elders with IK related to climate change mitigation and the disconnect between young people and IK bearers were limitations encountered during data collection.Originality/valueThe information in the article is an original compilation by the authors based on previous published work from the NetZero Heritage for Climate Action research project.
A geography of early vulnerabilities and exploitation in the narratives of adolescent males in England
Authors: Ashton Sally-Ann 
Published: September 2024

Purpose
The victimisation and criminal involvement of young people in organised criminal groups is a recognised form of child criminal exploitation (CCE) in the UK. Three phases of exploitation were identified (peer influence, adult street-level gangs and organised criminal groups). This paper aims to consider the locations associated with three stages of criminal exploitation and considers implications for safeguarding.

Design/methodology/approach
The research uses narratives of adolescent males and those of adults reflecting on their experiences as adolescents who had been immersed in street gangs and organised crime from northern England.

Method
Narratives of criminal action approach, a thematic analysis and multidimensional scaling (smallest space analysis) were undertaken to explore key locations in the planning and commissioning of a crime with at least one other person.

Findings
The narratives revealed that local and regional geographic locations relate to the stages of CCE. They offer an insight into the process of CCE and identify locations that could be used as a risk indicator for police forces and safeguarding teams. A clear pathway from involvement with street-level gangs to direct contact with organised criminal groups was found. This transition was represented by a move from outdoor to indoor locations.

Research limitations/implications
Out of the 30 participants, 29 came from the same region in Northern England, spanning a period of 30 years. It is possible that the findings may be limited to this region, or that there have been changes to criminal structures and opportunities over this time.

Originality/value
Although drug selling and the movement of victims across the UK is central to CCE, comparatively little attention has been given to the locations where early exploitation takes place at a micro level. Practical implications for policing and safeguarding will be discussed.