bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implizite Assoziationen mit dem Tod: Erste Validierung einer deutschen Version des Impliziten Assoziationstests für Suizidalität (Suizid-IAT)
Authors: Rath Dajana , Hallensleben Nina , Glaesmer Heide , Spangenberg Lena , Strauss Maria , Kersting Anette , Teismann Tobias , Forkmann Thomas 
Published: June 2017

ZusammenfassungNock, Park, Finn, et al. 1 entwickelten einen impliziten Assoziationstest für Suizid (Suizid-IAT), der die Stärke der Assoziation zwischen den Kategorien ‚Tod‘ und ‚Ich‘ misst. Sie konnten zeigen, dass Patienten mit einem Suizidversuch eine stärkere Assoziation zwischen ‚Tod‘ und ‚Ich‘ als zwischen ‚Leben‘ und ‚Ich‘ zeigten im Vergleich zu Patienten ohne Suizidversuch. Ziel dieser Studie ist die Vorstellung einer deutschen Version des IATs für Suizid von Nock, Park, Finn, et al. 1 sowie dessen Validierung an einer Stichprobe aus 16 Patienten mit einer depressiven Störung und Suizidgedanken sowie 16 nicht depressiven Kontrollprobanden ohne Suizidgedanken. Außerdem untersuchen wir Zusammenhänge zwischen dem IAT und Suizidgedanken, -verhalten, bekannten Risikofaktoren für Suizidalität wie Depressivität und Hoffnungslosigkeit sowie den zentralen Konzepten der Interpersonalen Theorie suizidalen Verhaltens und Erlebens nach Joiner 2, Thwarted Belongingness und Perceived Burdensomeness. Es zeigte sich, dass Patienten ‚Tod‘ und ‚Ich‘ stärker assoziieren als Kontrollprobanden. Darüber hinaus fanden wir bedeutsame Zusammenhänge impliziter Assoziationen zwischen ‚Tod‘ und ‚Ich‘ mit expliziten Auskünften zu suizidalem Verhalten – über Depressivität, Hoffnungslosigkeit und Suizidgedanken hinaus. Die Ergebnisse sprechen für die Validität dieser deutschen Version des Suizid-IATs und werden im Licht der Theorie suizidalen Verhaltens sowie der aktuellen Suizidforschung diskutiert.
Low-Intensity Cognitive Behavioral Therapy (LI-CBT) – Eine Einführung in Konzepte und Rahmenbedingungen
Authors: Wabnitz Pascal , Löhr Michael , Nienaber André , Hemkendreis Bruno , Kronmüller Klaus , Schulz Michael 
Published: June 2017

ZusammenfassungDie Bezeichnung Low-Intensity Cognitive Behavioral Therapie (LI-CBT) (in der Übersetzung etwa „niedrigintensive kognitive Verhaltenstherapie“) beschreibt Versorgungsangebote, die das Ziel verfolgen, den Zugang zu evidenzbasierten psychologischen Therapien zu verbessern. Dies wird erreicht indem (1) die Kontaktzeit zwischen Therapeut und Patient reduziert wird, (2) Fachkräfte mit speziellem Training aber ohne langjährige psychotherapeutische Qualifikation und (3) Interventionen mit variabler Intensität eingesetzt werden. Gestufte (Stepped-care) und berufsgruppen-vernetzende (Collaborative-care) Versorgungsstrukturen bilden den strukturellen Rahmen für eine erfolgreiche Umsetzung von LI-CBT. Während sich international großangelegte Forschungs- und Praxisprojekte diesem Thema widmen, liegt die Entwicklung in Deutschland deutlich zurück. Gerade vor dem Hintergrund wachsender Bedarfe und Inanspruchnahmen sowie der Zielsetzung von politischer Seite, neue Versorgungsformen zu entwickeln, stellte das Konzept LI-CBT daher einen vielversprechenden Ansatz dar.
Die Eignung der HoNOS (Health of the Nation Outcome Scales) zur Erfassung des Verlaufs und des Schweregrads depressiver Symptomatik im stationären Setting
Authors: Fankhauser Sonja , Hochstrasser Barbara , Sievers Marcus , Soyka Michael 
Published: June 2017

Zusammenfassung
Ziel Diese Studie untersuchte die Eignung der „Health of the Nation Outcome Scales“ (HoNOS) zur Erfassung des Verlaufs depressiver Symptomatik und des Schweregrads der Depression im stationären Setting.
Methode Die Stichprobe umfasste 132 depressive Patienten (F32: n=102; F33: n=30). Die HoNOS wurden mittels bivariaten Korrelationen mit der selbstbeurteilten (BDI) und fremdbeurteilten Depressivität (HAMD) verglichen. Die prädiktive Validität wurde mit linearen Regressionsanalysen untersucht.
Ergebnisse Die HoNOS differenzierten zwischen Patienten mit einer mittelgradigen versus schweren Depression (p<0,05) und korrelierten mit der Veränderung der fremdbeurteilten (r=0,25, p<0,008), jedoch nicht mit derjenigen der selbstbeurteilten Depressivität (r=0,19, p>0,008). Die HoNOS sagten die Depressivität bei Austritt nicht voraus (β=0,03, p>0,05).
Schlussfolgerung Da die HoNOS den Verlauf und Schweregrad depressiver Symptomatik nur teilweise erfassen, sollten sie nur kombiniert mit anderen depressionsspezifischen Messinstrumenten angewendet werden.
Deutschsprachige Kurzskalen zur Erfassung auffälligen Essverhaltens
Authors: Richter Felicitas , Strauß Bernhard , Berger Uwe 
Published: June 2017

ZusammenfassungDie Entwicklung von Kurzskalen ist in den letzten Jahren zu einem wichtigen Teilbereich klinisch-psychologischer Diagnostik geworden. Kurzskalen bieten auf Grund ihrer wenigen Items und der schnellen und einfachen Handhabung wesentliche Vorteile für Anwender und Anwenderinnen. Jedoch wird häufig die psychometrische Güte im Rahmen der Entwicklung und Validierung der Verfahren zweitrangig behandelt. Die folgende Übersichtsarbeit stellt 6 Kurzskalen zur Diagnostik von auffälligem Essverhalten und Essstörungen vor: Eating Attitudes Test 8 (EAT-8) Eating Disorder Examination-Questionnaire 8 (EDE-Q8) mit der dazugehörigen Version für Kinder (ChEDE-Q8), ICD-10-Symptom-Rating Subskala Essstörungen (ISR-E), SCOFF-Fragebogen und Short Evaluation of Eating Disorders (SEED). Es wird ein Überblick über die aktuellen Validierungsstudien der deutschen Versionen gegeben. Da nicht jede Kurzskala für jeden Anwendungsbereich und jede Population validiert ist, sollten Anwender und Anwenderinnen bei der Auswahl des Verfahrens auf die Eignung und psychometrische Güte der Kurzskala achten. Ziel der Übersichtsarbeit ist es, die Auswahl und Anwendung eines geeigneten Verfahrens für verschiedene Einsatzgebiete zu erleichtern.
Tanz mit Spitzenschuhen: Besonderheiten, körperliche Voraussetzungen und Tauglichkeitskriterien
Authors: Wanke Eileen , Exner-Grave Elisabeth 
Published: June 2017

ZusammenfassungDas Training mit Spitzenschuhen ist ein fester Bestandteil des klassischen und neoklassischen Tanzes, im professionellen Ausbildungs- sowie im ambitionierten Hobbytanzbereich. Der vor über 100 Jahren entwickelte – und seither nicht grundlegend veränderte dafür notwendige Spitzenschuh – ist hochspezifisch und ein Kompromiss zwischen Ästhetik, Funktion, Sicherheit und Gesundheit. Vor jedem Trainingsbeginn sollte daher eine Überprüfung der Eignung stehen. Mit dieser Fragestellung werden regelmäßig auf dem Gebiet der Medizin tätige Fachkräfte konfrontiert. Für eine Spitzentanz-Eignung (SST) müssen besondere anatomische, sich an der Tanztechnik orientierende allgemeine konditionelle und koordinative sowie spezifische tanztechnische Voraussetzungen erfüllt sein, um sowohl das akute Verletzungsrisiko als auch die Entstehung langfristiger Schäden möglichst gering zu halten. Dafür stehen neben einer (Trainings-)Anamnese mittlerweile verschiedene Testverfahren zur Verfügung, die im Verlauf einer Beratung eine zuverlässige Entscheidung für oder gegen den Spitzentanz ermöglichen. Unter Berücksichtigung der Zielgruppen professioneller Bühnentanz und Hobbytanz liefert dieser Beitrag Grundlagen und strukturierte Handlungsempfehlungen für Spitzentanz-Tauglichkeitsuntersuchungen (SST-TEST).
DNA Barcoding for Industrial Quality Assurance
Authors: Sgamma Tiziana , Lockie-Williams Claire , Kreuzer Marco , Williams Sarah , Scheyhing Ulrike , Koch Egon , Slater Adrian , Howard Caroline 
Published: June 2017

AbstractDNA barcoding methods originally developed for the identification of plant specimens have been applied to the authentication of herbal drug materials for industrial quality assurance. These methods are intended to be complementary to current morphological and chemical methods of identification. The adoption of these methods by industry will be accelerated by the introduction of DNA-based identification techniques into regulatory standards and monographs. The introduction of DNA methods into the British Pharmacopoeia is described, along with a reference standard for use as a positive control for DNA extraction and polymerase chain reaction (PCR). A general troubleshooting chart is provided to guide the user through the problems that may be encountered during this process. Nevertheless, the nature of the plant materials and the demands of industrial quality control procedures mean that conventional DNA barcoding is not the method of choice for industrial quality control. The design of DNA barcode-targeted quantitative PCR and high resolution melt curve tests is one strategy for developing rapid, robust, and reliable protocols for high-throughput screening of raw materials. The development of authentication tests for wild-harvested Rhodiola rosea L. is used as a case study to exemplify these relatively simple tests. By way of contrast, the application of next-generation sequencing to create a complete profile of all the biological entities in a mixed herbal drug is described and its potential for industrial quality assurance discussed.
Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata
Authors: Dong Miao , Quan Li-Qiu , Dai Wei-Feng , Yan Shi-Li , Chen Chin-Ho , Chen Xuan-Qin , Li Rong-Tao 
Published: June 2017

AbstractThree new compounds (1 – 3), including a sesterterpenoid, aspterpenacid C (1), with an unusual 5/3/7/6/5 pentacyclic skeleton, together with seven known ones (4 – 10), were isolated from the ethanol extract of the traditional Chinese medicinal plant Swertia bimaculata. Their structures were elucidated on the basis of the methods of spectroscopic NMR, MS, and computational chemistry. The structure of 1 was further confirmed by single-crystal X-ray diffraction analysis. Compounds 1 – 10 were tested for activities on the inhibition of nitric oxide production and HIV-1 replication in vitro. Compound 1 exhibited moderate activity in inhibiting nitric oxide production (IC50 = 16.1 µM) and HIV-1 replication (EC50 = 1.35 µM).
Ionic CD3−Lck interaction regulates the initiation of T-cell receptor signaling
Authors: Li Lunyi , Guo Xingdong , Shi Xiaoshan , Li Changting , Wu Wei , Yan Chengsong , Wang Haopeng , Li Hua , Xu Chenqi 
Published: June 2017

Significance
Antigen-induced phosphorylation of T-cell receptor (TCR) is the first signaling event in T cells that determines the functional outcome of antigen stimulation. Here, we report a key regulatory mechanism of the initiation of TCR phosphorylation. Using biochemical and biophysical tools, we find that a basic residue-rich sequence in CD3ε subunit of TCR can efficiently recruit Lck via ionic interaction to initiate TCR phosphorylation. The mechanism reported here can aid in the design of better T-cell therapies such as the Chimeric Antigen Receptor T-cell therapies.
ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair
Authors: Chen Chun-Chin , Kass Elizabeth M. , Yen Wei-Feng , Ludwig Thomas , Moynahan Mary Ellen , Chaudhuri Jayanta , Jasin Maria 
Published: June 2017

Significance
The tumor suppressors BRCA1 and ATM have both been implicated in the early steps of homologous recombination, also termed homology-directed repair (HDR). However, how ATM genetically interacts with BRCA1 in this process is unclear. In mice carrying a breast cancer-derived mutation in the BRCA1 C-terminal (BRCT) domain, we find that ATM becomes essential for supporting the residual levels of HDR necessary to repair a DNA break. ATM-mediated HDR is not affected by the status of 53BP1, an antagonizing factor of BRCA1. ATM loss is associated with synthetic lethality of BRCT mutant mice, which provides insight into the therapeutic potential of utilizing ATM kinase inhibitors in combination with PARP-inhibitor therapy for certain BRCA1-deficient tumors.
Multimodal language use in Savosavo
Authors: Bressem Jana , Stein Nicole , Wegener Claudia 
Published: June 2017

AbstractDeparting from a short overview on pragmatic gestures specialized for the expression of refusal and negation, the article presents first results of a study on those gestures in Savosavo, a Papuan language spoken in the Solomon Islands in the Southwest Pacific. The paper focuses on two partly conventionalized gestures (sweeping and holding away) and shows that speakers of Savosavo use the gestures in a very similar way as speakers of German, English or French, for example. The article shows how a linguistic and semiotic analysis might serve to uncover proto-morpho-semantic structures in a manual mode of communication and contributes to a better understanding of the conventional nature and cross-linguistic distribution of gestures. Moreover, by examining partly conventionalized gestures in a small, little known and endangered language, it presents a particular approach to the analysis of multimodality in the field of language documentation.
Turkish students and their experiences during a short-term summer visit to the U.S.
Authors: Güvendir Emre 
Published: June 2017

AbstractThis study examined the language-related experiences of Turkish students during their time in the U.S., and how these experiences related to their perceptions about learning English in an English-speaking community and interacting with host community members. The study also examined why Turkish students preferred a native speaker environment such as the U.S. as a venue for learning English. The participants of the study included 31 Turkish students who took English classes in a short-term summer study program in the U.S. The study used face-to-face interviews for data collection and content analysis to categorize students’ experiences. Findings show that although the majority of the students benefited from their stay in the U.S., they faced various challenges that limited their interaction with the host community and restricted their access to language input.
Visualizing and comparing circular genomes using the CGView family of tools
Authors: Stothard Paul , Grant Jason R , Van Domselaar Gary 
Published: June 2017

Abstract
Graphical genome maps are widely used to assess genome features and sequence characteristics. The CGView (Circular Genome Viewer) software family is a popular collection of tools for generating genome maps for bacteria, organelles and viruses. In this review, we describe the capabilities of the original CGView program along with those of subsequent companion applications, including the CGView Server and the CGView Comparison Tool. We also discuss GView, a graphical user interface-enabled rewrite of CGView, and the GView Server, which offers several integrated analyses for identifying shared or unique genome regions relative to a collection of comparison genomes. We conclude with some remarks about our current development efforts related to CGView aimed at adding new functionality while increasing ease of use.
Carbon-ion radiotherapy for patients with advanced stage non–small-cell lung cancer at multicenters
Authors: Karube Masataka , Yamamoto Naoyoshi , Shioyama Yoshiyuki , Saito Junichi , Matsunobu Akira , Okimoto Tamaki , Ohno Tatsuya , Tsuji Hiroshi , Nakano Takashi , Kamada Tadashi 
Published: June 2017

ABSTRACT
Carbon-ion radiation therapy (CIRT) for advanced non–small-cell lung cancer (NSCLC) has not been well studied to date. This paper aimed to analyze a retrospective multicenter survey for detecting problems with the use of CIRT for Stage II and III NSCLC (7th UICC TNM Staging System). Inclusion was restricted to patients with Stage II and III NSCLC who received CIRT from November 2003 to December 2014. We gathered the data from three CIRT operating centers on July 2015. Patients with radiotherapy history, patients with cancers other than lung cancer, and those receiving palliative therapies were excluded. The patient characteristics, prescribed dose/fraction, survival rates, and adverse effects were analyzed. The total number of patients was 64 (male: 49, female: 15). Of these, 53 patients were medically inoperable. The median age was 76 years (range 46–91), and the median follow-up period was 18.5 months (range 3.2–121.5). The clinical staging consisted of 10 Stage IIA, 30 Stage IIB, 23 Stage IIIA and 1 Stage IIIB. The median prescribed dose was 72.0 Gy (RBE) (range 52.8–72.0) in 16 fractions (range 4–16). The 2-year overall survival, progression-free survival, and local control rates were 62.2% [confidence interval (CI): 47.5–76.9], 42.3% (CI: 28.8–55.8) and 81.8% (CI: 69.9–94.0), respectively. There were no higher than Grade 2 adverse effects observed. CIRT for inoperable Stage II and III NSCLC could be implemented without severe adverse effects, but the clinical staging (including lymph node status) was inhomogeneous. In addition, the prescribed dose and fractionation were not standardized. Further data accumulation and a multiple centers prospective trial for evaluating clinical stage–based results are required.
Efficacy and Safety of Combination Therapy of Shenfu Injection and Postresuscitation Bundle in Patients With Return of Spontaneous Circulation After In-Hospital Cardiac Arrest: A Randomized, Assessor-Blinded, Controlled Trial*
Authors: Zhang Qian , Li Chunsheng , Shao Fei , Zhao Lianxing , Wang Miaomiao , Fang Yingying 
Published: June 2017

Objectives:Postresuscitation care bundle treatment after return of spontaneous circulation in patients experiencing in-hospital cardiac arrest can improve patients’ survival and quality of life. The aim of the study was to evaluate the efficacy and safety of combined therapy of Shenfu injection and postresuscitation care bundle in these patients.Design:Prospective, randomized, controlled clinical study.Setting:Fifty hospitals in China.Patients:Adult patients had experienced in-hospital cardiac arrest between 2012 and 2015.Interventions:Based on the standardized postresuscitation care bundle treatment, patients were randomized to a Shenfu injection group (Shenfu injection + postresuscitation care bundle) or control group (postresuscitation care bundle) for 14 days or until hospital discharge. In the Shenfu injection group, 100 mL Shenfu injection was additionally administered via continuous IV infusion, bid.Measurements and Main Results:The primary outcome was 28-day survival after randomization. The secondary outcomes included 90-day survival as well as the duration of mechanical ventilation and the hospital stay and the total cost of hospitalization. Of 1,022 patients enrolled, a total of 978 patients were allocated to the two groups: the control (n= 486) and Shenfu injection (n= 492) groups. The Shenfu injection group had a significantly greater 28-day survival rate (42.7%) than the control group (30.1%). Also, the Shenfu injection group had a significantly higher survival rate at 90 days (39.6%) than the control group (25.9%). Compared with patients in the control group, patients in the Shenfu injection group had lower risks of 28-day mortality (hazard ratio, 0.61; 95% CI, 0.43–0.89;p= 0.009) and 90-day mortality (hazard ratio, 0.55; 95% CI, 0.38–0.79;p= 0.002). In the Shenfu injection group, the duration of mechanical ventilation (8.6 ± 3.2 vs 12.7 ± 7.9 d;p< 0.001) and the hospital stay (8.7 ± 5.9 vs 13.2 ± 8.1 d;p< 0.001) were significantly less than in the control group. Irreversible brain damage was the main cause of death in both groups. No serious drug-related adverse event was recorded.Conclusions:This study demonstrates that Shenfu injection in combination with conventional postresuscitation care bundle treatment is effective at improving clinical outcomes in patients with return of spontaneous circulation after in-hospital cardiac arrest.
AGE-RELATED MACULAR DEGENERATION AND THE RISK OF ALL-CAUSE AND CARDIOVASCULAR MORTALITY
Authors: Xin Xueling , Sun Yongye , Li Shiru , Xu Hui , Zhang Dongfeng 
Published: June 2017

Purpose:
We evaluated the association between age-related macular degeneration (AMD) and the risk of all-cause and cardiovascular mortality by meta-analyses of data from prospective studies.

Methods:
A literature search was performed in PubMed, Web of Science, Embase, Cocharne Library, and China National Knowledge Infrastructure for relevant articles published up to December 2016. We estimated hazard ratios with 95% confidence intervals with fixed-effect models and conducted meta-regression to explore the potential sources of heterogeneity. Small-study effect was estimated by Egger's test and funnel plot.

Results:
We identified 13 population-based prospective cohort studies that examined the relationship between AMD and all-cause and cardiovascular mortality. Overall, the hazard ratios (95% confidence intervals) of all-cause mortality and cardiovascular mortality associated with any AMD were 1.15 (1.05–1.27) and 1.05 (95% confidence intervals: 0.87–1.26), respectively. The risk of all-cause mortality and cardiovascular mortality associated with early AMD were 1.08 (1.00–1.18) and 1.05 (0.89–1.24), and the associations with late AMD were 1.23 (1.11–1.36) and 1.28 (1.04–1.57), respectively. No evidence of small-study effect was found.

Conclusion:
This meta-analysis indicated that AMD, especially late AMD, was associated with increased risk of all-cause mortality and cardiovascular mortality based on comparisons with people who did not have AMD and who were of similar age and sex.
THE RELATIONSHIP BETWEEN FOVEAL AVASCULAR ZONE AREA, VESSEL DENSITY, AND CYSTOID CHANGES IN DIABETIC RETINOPATHY
Authors: Tarassoly Kia , Miraftabi Arezoo , Soltan Sanjari Mostafa , Parvaresh Mohammad Mehdi 
Published: June 2017

Purpose:
To measure the foveal avascular zone (FAZ) areas and vessel densities of patients with diabetic retinopathy and to study their relationship with diabetic cystoid changes and retinal thickness.

Methods:
Prospective case series of 51 eyes of 31 patients with diabetic retinopathy. The eyes were grouped based on the presence or absence of cystoid edema and evaluated using optical coherence tomography angiography. The FAZ areas and vessel density were compared.

Results:
The FAZ area at the superficial capillary plexus level was equal between the eyes with and without cystoid edema. Vessel density did not differ as well. There was no correlation with retinal thickness. In eyes with cystoid changes, FAZ area changes at the deep capillary plexus level were difficult to interpret.

Conclusion:
The FAZ area and vessel density at the superficial capillary plexus level are reproducible and independent of the presence of cystoid edema.
MOLECULAR PROGNOSTICS FOR UVEAL MELANOMA
Authors: Seider Michael I. , Mruthyunjaya Prithvi 
Published: June 2017

Purpose:
To review laboratory methods, currently available commercial tests, caveats and clinical tips regarding prognostic analysis of uveal melanoma tissue.

Methods:
A review of the literature was performed focused on the genetic abnormalities found in uveal melanoma cells, their correlation to the development of metastases, the validity of various laboratory approaches in their detection, and the existing commercially available tests for uveal melanoma prognostication.

Results:
Numerous laboratory methods exist for analyzing genetic material obtained from uveal melanoma cells. Older tests have been gradually replaced with contemporary methods that are simpler with greater accuracy. Two commercially available assays exist which have not been directly compared—a gene expression profiling test has been validated directly through a large, prospective multicenter study and a DNA-based test which uses laboratory methods supported by extensive historical data.

Conclusion:
There are myriad laboratory methods for prognostic analysis of uveal melanoma tissue. These tests were historically only available to those with access to an outfitted laboratory. Newer commercially available assays have increased the accessibility of prognostic biopsy for uveal melanoma. The various caveats that exist when considering and performing prognostic biopsy of uveal melanoma are discussed.