bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data‐sparse numerical models for SNOM tips
Authors: Hafner Christian , Hiptmair Ralf , Souzangar Pegah 
Published: June 2016

SummaryWe propose a compressed non‐local surface‐impedance‐type boundary condition for the efficient numerical modeling of large geometrically persistent parts in multi‐scale electromagnetic simulations. The underlying compressed model is an approximate Schur complement of finite element Galerkin matrix. Our approach relies on local low‐rank representation in the framework of the
‐matrix storage format. We discuss two ways to build
‐matrix approximations of Schur‐complement matrices: adaptive cross approximation and
‐arithmetics. Profound numerical tests and studies of accuracy are carried out for an axisymmetric setting, employing the open source library AHMED by M. Bebendorf. To demonstrate the use of our method, we build the compressed model for an axisymmetric scanning near‐field optical microscopy tip. The model can be embedded in three‐dimensional tip‐sample simulations. Copyright © 2016 John Wiley & Sons, Ltd.
Impact of anthropogenic induced nitrogen input and liming on phosphorus leaching in forest soils
Authors: Holzmann Stefan , Missong Anna , Puhlmann Heike , Siemens Jan , Bol Roland , Klumpp Erwin , Wilpert Klaus von 
Published: June 2016

AbstractPhosphorus (P) is essential for sustainable forest growth, yet the impact of anthropogenic impacts on P leaching losses from forest soils is hardly known. We conducted an irrigation experiment with 128 mesocosms from three forest sites representing a gradient of resin extractable P of the A‐horizon. On each site we selected a Fagus sylvatica and a Picea abies managed subsite. We simulated ambient rain (AR), anthropogenic nitrogen input (NI) of 100 kg (ha · a)−1 and forest liming (FL) with a dolomite input of 0.3 Mg (ha · a)−1. Soil solution was extracted from the organic layer, 10 cm depth and 20 cm depth of the mesocosms, and analyzed for molybdate reactive phosphorus (MRP) and molybdate unreactive phosphorus (MUP). Additionally, we separated colloids from the soil solution using Asymmetric Field Flow Fractionation for assessing the colloidal fraction of total element concentrations. NI increased MRP and MUP concentrations for all plots with one exception, while FL decreased MRP and MUP with the exception of another plot. While the irrigation treatments had little impact on the P‐richest site, MRP and MUP concentrations changed strongly at the poorer sites. The colloidal fraction of P in the soil solution equaled 38–47% of the total P load. Nitrogen input and liming also affected the Fe, Al, Ca, and Corg contents of the colloidal fraction.
Capacitive Detection of Morphine via Cathodically Electropolymerized, Molecularly Imprinted Poly(p‐aminostyrene) Films
Authors: Vergara Aileen V. , Pernites Roderick B. , Tiu Brylee David B. , de Leon Al Christopher C. , Mangadlao Joey D. , Binag Christina A. , Advincula Rigoberto C. 
Published: June 2016

Highly sensitive and selective detection of morphine is exhibited using a capacitive transducer coated with cathodically electropolymerized and molecularly imprinted poly(p aminostyrene). Through molecular imprinting, morphine‐specific recognition sites have been fabricated throughout the film, which shows exceptional binding activity toward morphine based from electrochemical capacitance measurements. The thin film sensor has a linear response to morphine solutions with 20–40 × 10−6 m concentrations and a detection limit of 5.95 × 10−6 m. It demonstrates high selectivity toward morphine as compared to other analog molecules including nicotine and cholesterol. The formation of the polymer film is facilitated and monitored using electrochemical‐quartz crystal microbalance and characterized by X‐ray photoelectron spectroscopy. Infrared spectroscopy confirms the loading and removal of the analyte from the film. Based on molecular modeling calculations, strong hydrogen‐bonding interactions between the monomer, cross‐linker, and analyte form a stable pre‐polymerization complex, which is critical in successfully imprinting morphine into the film and effective sensing of the analyte.
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A FIC‐based stabilized mixed finite element method with equal order interpolation for solid–pore fluid interaction problems
Authors: de‐Pouplana Ignasi , Oñate Eugenio 
Published: June 2016

SummaryA new mixed displacement‐pressure element for solving solid–pore fluid interaction problems is presented. In the resulting coupled system of equations, the balance of momentum equation remains unaltered, while the mass balance equation for the pore fluid is stabilized with the inclusion of higher‐order terms multiplied by arbitrary dimensions in space, following the finite calculus (FIC) procedure. The stabilized FIC‐FEM formulation can be applied to any kind of interpolation for the displacements and the pressure, but in this work, we have used linear elements of equal order interpolation for both set of unknowns. Examples in 2D and 3D are presented to illustrate the accuracy of the stabilized formulation for solid–pore fluid interaction problems. Copyright © 2016 John Wiley & Sons, Ltd.
Evaluating the safety of intermittent intravenous sildenafil in infants with pulmonary hypertension
Authors: Darland Leanna K. , Dinh Kimberly L. , Kim Shelly , Placencia Jennifer L. , Varghese Nidhy P. , Ruiz Fadel , Mallory George B. , Fernandes Caraciolo J. 
Published: June 2016

SummaryObjectiveTo compare the occurrence of hypotension following administration of intermittent intravenous (IV) and enteral sildenafil for treatment of pulmonary hypertension (PH) in infants. We hypothesized there may be more adverse effects associated with intermittent IV sildenafil compared with enteral sildenafil.MethodsThis was a retrospective matched‐cohort study conducted in a tertiary care children's hospital. Patients were included if they were less than 1 year of age and received intermittent sildenafil for PH. Exclusion criteria consisted of concurrent extracorporeal membrane oxygenation during the initiation of sildenafil, the utilization of sildenafil as a one‐time dose, continuation of home‐dosing regimen, or inclusion in the other cohort. A total of 40 patients were matched 1:1 based on postmenstrual age and primary diagnosis.ResultsThere was no statistically significant difference in the primary outcome, as 30% (6/20) of patients receiving IV sildenafil required a hypotension intervention compared with 10% (2/20) in the enteral cohort (P = 0.24). The majority of interventions occurred within 24 hr of the initiation of sildenafil with 4/6 patients (67%) in the IV group and 2/2 patients (100%) in the enteral group, respectively. Baseline mean arterial pressure was significantly lower in the IV patients that required an intervention compared with those that did not (44 ± 6.3 vs. 65 ± 13.4 mmHg, P = 0.0024).ConclusionsThere were no statistically significant differences in safety outcomes between intermittent IV and enteral sildenafil in infants with PH. Hemodynamic parameters should be monitored closely upon sildenafil initiation. Limitations include the retrospective nature and small sample size. Pediatr Pulmonol. 2017;52:232–237. © 2016 Wiley Periodicals, Inc.
CXCR4+CD45− Cells are Niche Forming for Osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 Signaling Pathways in Bone Marrow
Authors: Goto Yoh , Aoyama Mineyoshi , Sekiya Takeo , Kakita Hiroki , Waguri-Nagaya Yuko , Miyazawa Ken , Asai Kiyofumi , Goto Shigemi 
Published: June 2016

Abstract
Bone homeostasis comprises the balance between bone-forming osteoblasts and bone-resorbing osteoclasts (OCs), with an acceleration of osteoclastic bone resorption leading to osteoporosis. OCs can be generated from bone marrow cells (BMCs) under the tightly regulated local bone environment. However, it remained difficult to identify the critical cells responsible for providing an osteoclastogenesis niche. In this study, we used a fluorescence-activated cell sorting technique to determine the cell populations important for forming an appropriate microenvironment for osteoclastogenesis and to verify the associated interactions between osteoclast precursor cells and non-OCs. We isolated and removed a small cell population specific for osteoclastogenesis (CXCR4+ CD45−) from mouse BMCs and cultured the remaining cells with receptor activator of nuclear factor-kappa B ligand (RANKL) and macrophage-colony stimulating factor. The resulting cultures showed significantly less large osteoclast formation. Quantitative RT-PCR analysis revealed that these CXCR4+ CD45− cells expressed low levels of RANK and RANKL, but high levels of critical chemokines including stromal cell derived factor 1 (SDF-1), chemokine (C-X-C motif) ligand 7 (CXCL7), and chemokine (C-X3-C motif) ligand 1 (CX3CL1). Furthermore, an SDF-1-specific antibody strongly suppressed OC formation in RAW264.7 cells and antibodies against SDF-1, CXCL7, and CX3CL1 suppressed OC formation in BMCs. These results suggest that isolated CXCR4+ CD45− cells support an appropriate microenvironment for osteoclastogenesis with a direct effect on the cells expressing SDF-1, CXCL7, and CX3CL1 receptors. The regulation of CXCR4+ CD45− cell function might therefore inform therapeutic strategies for diseases involving loss of bone homeostasis.
Local CXCR4 Upregulation in the Injured Arterial Wall Contributes to Intimal Hyperplasia
Authors: Shi Xudong , Guo Lian-Wang , Seedial Stephen , Takayama Toshio , Wang Bowen , Zhang Mengxue , Franco Sarah R. , Si Yi , Chaudhary Mirnal A , Liu Bo , Kent K. Craig 
Published: June 2016

Abstract
CXCR4 is a stem/progenitor cell surface receptor specific for the cytokine stromal cell-derived factor-1 (SDF-1α). There is evidence that bone marrow-derived CXCR4-expressing cells contribute to intimal hyperplasia (IH) by homing to the arterial subintima which is enriched with SDF-1α. We have previously found that transforming growth factor-β (TGFβ) and its signaling protein Smad3 are both upregulated following arterial injury and that TGFβ/Smad3 enhances the expression of CXCR4 in vascular smooth muscle cells (SMCs). It remains unknown, however, whether locally induced CXCR4 expression in SM22 expressing vascular SMCs plays a role in neointima formation. Here, we investigated whether elevated TGFβ/Smad3 signaling leads to the induction of CXCR4 expression locally in the injured arterial wall, thereby contributing to IH. We found prominent CXCR4 upregulation (mRNA, 60-fold; protein, 4-fold) in TGFβ-treated, Smad3-expressing SMCs. Chromatin immunoprecipitation assays revealed a specific association of the transcription factor Smad3 with the CXCR4 promoter. TGFβ/Smad3 treatment also markedly enhanced SDF-1α-induced ERK1/2 phosphorylation as well as SMC migration in a CXCR4-dependent manner. Adenoviral expression of Smad3 in balloon-injured rat carotid arteries increased local CXCR4 levels and enhanced IH, whereas SMC-specific depletion of CXCR4 in the wire-injured mouse femoral arterial wall produced a 60% reduction in IH. Our results provide the first evidence that upregulation of TGFβ/Smad3 in injured arteries induces local SMC CXCR4 expression and cell migration, and consequently IH. The Smad3/CXCR4 pathway may provide a potential target for therapeutic interventions to prevent restenosis.
Performance–cost optimization of tuned mass damper under low‐moderate seismic actions
Authors: Greco Rita , Marano Giuseppe Carlo , Fiore Alessandra 
Published: June 2016

SummaryIn this paper, a multi‐objective optimization of a single tuned mass damper is proposed at the aim to control vibrations induced in building structures under low‐moderate earthquakes. The optimum design is carried out by considering both economic and performance criteria. The cost of the device is the economic objective that is assumed directly related to its mechanical parameters. At the aim to control the damage level and the behaviour of components and equipment, the ratio between the absolute accelerations of the protected structure and the unprotected one is assumed as the device performance. A multi‐objective optimization is then formulated, and Pareto optimum solutions are achieved by the Non‐dominated Sorting Genetic Algorithm in its second version. Finally, a sensitivity analysis of the optimum solution with respect to some input data is carried out. Copyright © 2016 John Wiley & Sons, Ltd.
Syntheses, Structures, and Electrochemical Properties of Two Bis‐triazole‐bis‐amide‐based Copper(II) Pyridine‐2,3‐dicarboxylate Coordination Polymers
Authors: Zhang Ju‐Wen , Li Xiao‐Li , Kan Xiao‐Min , Liu Ying , Liu Bin‐Qiu 
Published: June 2016

AbstractAbstract. Two bis‐triazole‐bis‐amide‐based copper(II) pyridine‐2,3‐dicarboxylate coordination polymers (CPs), [Cu(2,3‐pydc)(dtb)0.5(DMF)]·2H2O (1) and [Cu(2,3‐pydc)(dth)0.5(DMF)]·2H2O (2) (2,3‐H2pydc = pyridine‐2,3‐dicarboxylic acid, dtb = N,N′‐bis(4H‐1,2,4‐triazole)butanamide, and dth = N,N′‐bis(4H‐1,2,4‐triazole)hexanamide), were synthesized under solvothermal conditions. CPs 1 and 2 show similar two‐dimensional (2D) structures. In 1, the 2,3‐pydc anions bridge the CuII ions into a one‐dimensional (1D) chain. Such 1D chains are linked by the dtb ligands to form a 2D layer. The adjacent 2D layers are extended into a three‐dimensional (3D) supramolecular architecture by hydrogen‐bonding interactions. The electrochemical properties of 1 and 2 were investigated.
Autologous but not Fibrin Sealant Patches for Stump Coverage Reduce Clinically Relevant Pancreatic Fistula in Distal Pancreatectomy: A Systematic Review and Meta‐analysis
Authors: Weniger Maximilian , D’Haese Jan Goesta , Crispin Alexander , Angele Martin Kurt , Werner Jens , Hartwig Werner 
Published: June 2016

AbstractBackgroundPostoperative pancreatic fistula (POPF) causes significant morbidity and mortality after distal pancreatectomy. Patch coverage of the pancreatic stump is often used with the intention to prevent POPF. Despite numerous investigations, the effects of patch coverage remain unclear. The present meta‐analysis aims to clarify the effects of patch coverage in distal pancreatectomy on the incidence of POPF.MethodsA systematic search of MEDLINE/PubMed and the Cochrane Database according to the PRISMA Statement was performed. Subsequently a meta‐analysis on rates and overall incidence of POPF and length of hospital stay was carried out. By applying the inverse variance weighting method, the combined effect size and 95 % confidence interval were calculated. Heterogeneity was assessed using I2 statistics.ResultsFive randomized controlled trials and six observational clinical studies were included for final analysis. A cumulative incidence of 43 % of POPF grades A–C was identified. Patch coverage in distal pancreatectomy is significantly associated with a decreased rate of POPF grade C (p = 0.006). Patches of autologous vascularized tissue significantly reduce the overall incidence of POPF (p = 0.04) and clinically relevant POPF grade B and C (p = 0.002). Fibrin sealant patches do not influence rates of POPF after distal pancreatectomy. None of the outcomes evaluated showed adverse results for the patch group.ConclusionsPatch coverage after distal pancreatectomy can reduce the rate of POPF. Patch coverage with autologous vascularized tissue but not fibrin sealant patches may be used to reduce clinically relevant POPF and postoperative morbidity in distal pancreatectomy.
Value-based process project portfolio management: integrated planning of BPM capability development and process improvement
Authors: Lehnert Martin , Linhart Alexander , Röglinger Maximilian 
Published: June 2016

AbstractBusiness process management (BPM) is an important area of organizational design and an acknowledged source of corporate performance. Over the last decades, many approaches, methods, and tools have been proposed to discover, design, analyze, enact, and improve individual processes. At the same time, BPM research has been and still is paying ever more attention to BPM itself and the development of organizations’ BPM capability. Little, however, is known about how to develop an organization’s BPM capability and improve individual processes in an integrated manner. To address this research gap, we developed a planning model. This planning model intends to assist organizations in determining which BPM- and process-level projects they should implement in which sequence to maximize their firm value, catering for the projects’ effects on process performance and for interactions among projects. We adopt the design science research (DSR) paradigm and draw from project portfolio selection as well as value-based management as justificatory knowledge. For this reason, we refer to our approach as value-based process project portfolio management. To evaluate the planning model, we validated its design specification by discussing it against theory-backed design objectives and with BPM experts from different organizations. We also compared the planning model with competing artifacts. Having instantiated the planning model as a software prototype, we validated its applicability and usefulness by conducting a case based on real-world data and by challenging the planning model against accepted evaluation criteria from the DSR literature.
Functional characteristics of left ventricular synchronization via right ventricular outflow‐tract pacing detected by two‐dimensional strain echocardiography
Authors: Hirayama Yasutaka , Kawamura Yuichiro , Sato Nobuyuki , Saito Tatsuya , Tanaka Hideichi , Saijo Yasuaki , Kikuchi Kenjiro , Ohori Katsumi , Hasebe Naoyuki 
Published: June 2016

AbstractBackgroundRecently, due to the detrimental effects on the ventricular function associated with right ventricular apical (RVA) pacing, right ventricular septal (RVS) pacing has become the preferred pacing method. However, the term RVS pacing refers to both right ventricular outflow‐tract (RVOT) and mid‐septal (RVMS) pacing, leading to a misinterpretation of the results of clinical studies. The purpose of this study, therefore, was to elucidate the functional differences of RVA, RVOT, and RVMS pacing in patients with atrioventricular block.MethodsWe compared the QRS duration, global longitudinal strain (GLS), and left ventricular (LV) synchronization parameters at the three pacing sites in 47 patients. The peak systolic strain (PSS) time delay between the earliest and latest segments among the 18 LV segments and standard deviation (SD) of the time to the PSS were also calculated for the 18 LV segments at each pacing site using two‐dimensional (2D) strain echocardiography.ResultsRVMS pacing was associated with a significantly shorter QRS duration compared with RVA and RVOT pacing (154.4±21.4 vs 186.5±19.9 and 171.1±21.5 ms, P<0.001). In contrast, RVOT pacing revealed a greater GLS (−14.69±4.92 vs −13.12±4.76 and −13.51±4.81%, P<0.001), shorter PSS time delay between the earliest and latest segments (236.0±87.9 vs 271.3±102.9 and 281.9±126.6%, P=0.007), and shorter SD of the time to the PSS (70.8±23.8 vs 82.7±30.8 and 81.5±33.7 ms, P=0.002) compared with RVA and RVMS pacing.ConclusionsThese results suggest that the functional characteristics of RVOT pacing may be a more optimal pacing site than RVMS, regardless of the pacing QRS duration, in patients with atrioventricular conduction disorders.
Localization of the Lateral Retinacular Nerve for Diagnostic and Therapeutic Nerve Block for Lateral Knee Pain: A Cadaveric Study
Authors: Sutaria Rakhi G. , Lee Se Won , Kim Soo Yeon , Howe Ruth , Downie Sherry A. 
Published: June 2016

AbstractBackgroundThe lateral retinacular nerve (LRN) is a branch of the superior lateral genicular nerve (SLGN) and is believed to contribute to anterolateral knee pain. The precise anatomical pathway of the LRN, however, has not been demonstrated as it relates to the performance of targeted nerve block procedures.ObjectiveTo describe the anatomical landmarks for localization of the LRN to facilitate diagnostic and therapeutic nerve blocks in the treatment of chronic anterolateral knee pain.DesignDescriptive study.SettingAnatomy dissection laboratory in an academic institution.MethodsTwenty lower extremities were dissected in 12 cadavers. The sciatic nerve was identified, and its branch to the posterior aspect of the knee, the SLGN, was dissected. The SLGN dissection was continued distally to identify its first branch, the LRN. Two measurements were taken from the branch point on the lateral knee deep to the distal biceps tendon in alignment with the fibular head. A validation study completed in 4 knees was performed as follows: 1 mL of colored dye was injected at the first and second measurements. The cadaveric knee was then dissected to assess the accuracy.Main Outcome MeasurementsLocalization of the branch point of the LRN from the SLGN via dissection and then direct assessment of injected dye at the measurement points via dissection.ResultsThe branch point of the LRN from the SLGN was, on average, 5.5 ± 0.66 cm (with a range of 4.5‐7.0 cm) proximal to the lateral tibiofemoral joint line in line with the head of the fibula and 2.6 ± 0.62 cm (2.0‐4.5 cm) proximal to the tip of the lateral femoral epicondyle. On assessment of the 2 measurements, the measurement 5.5 cm proximal to the lateral joint line accurately targeted the branch point in 100% (4/4) of the knees, whereas the measurement 2.6 cm proximal the tip of the lateral femoral epicondyle accurately targeted the branch point in 75% (3/4) of the knees.ConclusionThe results of this study provide 2 dependable landmarks and a description of the path of the LRN, making it possible to accurately target the LRN to diagnose and alleviate lateral knee pain.
Intrathecal management of complex regional pain syndrome: A case report and literature
Authors: Hagedorn Jonathan M. , Atallah George 
Published: June 2016

Abstract

Background and purpose
Complex regional pain syndrome (CRPS) is a painful condition typically resulting from a traumatic event. Pain control in these patients is often difficult and requires a multimodal approach. Our objectives are to present a single intrathecal pain management regimen for CRPS and provide a literature review of intrathecal pain management options in CRPS.

Methods
Case report from an academic pain management clinic.

Case report
We present the case of a 29-year-old female with a past medical history of multiple lumbar spine surgeries and lumbar post-laminectomy syndrome who presented to clinic with CRPS type II of the bilateral lower extremities. After failing conservative measures, she underwent placement of a successful intrathecal drug delivery system.

Conclusion
The use of intrathecal medications is useful for pain control in CRPS patients.

Implications
We provide a framework for treatment of CRPS, which could be useful for practitioners dealing with this difficult and painful condition.