bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetics and epigenetics of syntropic diseases
Authors: Gorbunova Viktoriya N 
Published: September 2017

The genetic components are involved in aetiology of the common human diseases. For most of them it is significant the phenomenon of syntropies — nonrandom combination of different diseases in the same patients. Three methodic approaches have been successfully used for the identification of genetic factors predisposed to the common human diseases: linkage analysis, candidate gene association studies (GASs) and genome-wide association scans (GWASs). The structural features of the many genes make a small but significant contribution to the overall risk of common diseases. Syntropy of related diseases is determined of having of share in disease pathogenesis the functional polymorphisms of genes controlling the same metabolic pathways. Nonrandom combination of different diseases in the same patients is determined of common epigenetic mechanisms involved in expression control of different «gene nets» disorder.
Epigenetical mechanisms of susceptibility to complex human diseases
Authors: Patkin Eugene L , Quinn John 
Published: September 2017

Contemporary data concerned an input of epigenetical mechanisms into an etiology and susceptibility to complex human diseases are critically analyzed. The special attention is attended to a specific role of simple tandem DNA repeats, the crucial role of developmental epigenetics in these processes. Patterns of mitotic and intergenerational inheritance of epigenetical modifications are considered.
Noncoding RNA participation in gene expression regulation in yeast Saccharomyces cerevisiae
Authors: Kochenova Olga V 
Published: September 2017

Saccharomyces cerevisiae lacks the main components of RNAi-dependent gene silencing. Nevertheless, regulation of gene expression in S. cerevisiae could be accomplished via some other types of noncoding RNA, particularly via antisense RNA. Although, there is a high percent of untranslated RNA in yeast genome only few evidences of noncoding RNA gene regulation exist in yeast S. cerevisiae, some of them are reviewed in the present paper.
Y CHROMOSOME HAPLOGROUP R1a1a7 (М458) OF MODERN BELARUSIANS AND MIGRATIONS OF SLAV’S PREDECESSORS ON BELARUS TERRITORY
Authors: Kushnerevich Elena I , Sivitskaya Larisa N , Bogacheva Anna V , Kotova Svetlana A , Tsybovsky Iosif S , Davydenko Oleg G 
Published: September 2017

Investigation of Y chromosome haplogroup R1a1a7 (М458) in ethnic Belarusians from six historic and ethnographic regions has shown that its frequency makes up 14% out of total Y chromosome gene pool diversity. Bearers of R1a1a7 (М458) are concentrated in Pripiat and Neman river basins which is in south and west of Belarus respectively. Expansion of R1a1a7 (М458) on the territory of present day Belarus was most probable associated with the distribution of agriculture in Eastern Europe. In addition, obtained data point to presence of later migration wave, Polab Slavs, for example, from Elba and Oder interfluves in Neman river basin at the border of I–II Millennia.
APOE gene ε4/ε4 “thrifty” genotype and risk of metabolic disorders in the Uralic peoples
Authors: Kozlov Andrey I , Borinskaya Svetlana A , Sanina Ekaterina D 
Published: September 2017

The prevalence of APOE gene ε4/ε4 genotype in the populations with various level of “westernization” is under the consideration. It is proposed that the populations with a high frequency of *ε4 undergoing “modernization transition” are in the most vulnerable state. These are the Eastern Finns and especially indigenous people of the North, who have a higher level of diseases of circulatory system than megacity residents.
GENETIC AND MORPHOTYPIC HETEROGENEITY OF SWIMMING POOL BACTERIAL POPULATIONS
Authors: Magdanova Larisa A , Golyasnaya Nadezhda V 
Published: September 2017

The populations of resident bacterial species of the swimming pool community such as Pseudomonas aeruginosa, Bacillus sp., Acinetobacter lwoffii and Pseudomonas alcaligenes were analyzed. All these species showed stable in time heterogeneity by spontaneous mutation frequency and biofilm forming ability. There was notably high occurrence of mutators in all investigated populations. Our results show high level of genetic plasticity and adaptivity under conditions of starvation and exposure to biocides.
EPIGENETIC ASPECTS OF ABNORMALITIES OF HUMAN EMBRYO DEVELOPMENT
Authors: Lebedev Igor N 
Published: September 2017

Early stages of human embryo development are characterized by an extremely high incidence of reproductive losses. Genomic mutations are the main contributing factor in this phenomenon. However, a significant part of miscarriages cannot explained by current genetic or cytogenetic concepts. A possible impact of abnormalities of the epigenetic genome organization into etiology of reproductive wastages is discussed in the current review. Characteristics of aberrant epigenetic modifications, ontogenetic and molecular mechanisms of their appearance are given in the light of genomic imprinting.
Methylation anomalies in cancerogenesis: search for new genes, development of methods and DNA-markers for diagnosis
Authors: Zaletaev Dmitry V , Strelnikov Vladimir V , Kekeeva Tatiana V , Zemliakova Valeria V , Kuznetsova Ekaterina B , Mikhaylenko Dmitri S 
Published: September 2017

The report considers the epigenetic defects and their diagnostics in tumors. Aberrant methylation of the promoter or regulatory region of a gene results in its functional inactivation, which is phenotypically similar to structural deletion. Cancerogenesis-associated genes are often methylated in tumors. Tumors differ in methylation frequencies, allowing differential diagnostics. Aberrant methylation of tumor suppressor genes occurs in early cancerogenesis, and its detection may be employed in presymptomatic and noninvasive diagnostics of tumors.
Is biological invasion crucible for evolution?
Authors: Orlova Marina I 
Published: September 2017

During the invasion process multiply introductions via invasion corridors support contacts of propagules from populations isolated before. The contacts occur outside their native range in conditions of differently disturbed ecosystems. Universal genetic mechanisms form the material that is both diverse and unique for natural selective pressure in these contact zones. Invasions provide prerequisites for co-evolution of species having the same origin (and so far period of preceding co-evolution) and those of different regions. Their further co-evolution can occur in recipient system including as formation of new assemblages.
DEVELOPMENT OF MOLECULAR MARKER FOR ASSESSMENT OF INTRASPECIFIC POLYMORPHISM OF RC GENE CONDITIONING RED PERICARP IN RICE ORYZA SATIVA L.
Authors: Tokmakov Sergey V , Mukhina Zhanna M , Bogomaz Denis I , Matveeva Tatyana V 
Published: September 2017

Red rice is the worst field weed in all rice-cultivation areas. Early diagnosis of red rice in primary seed breeding program is an overriding task, which solution directly influences the quality of the rice seeds. Red and red-brown colors of pericarp are determined by two loci at least: Rc and Rd, expressing in conjunction with the Rc gene. In this study we have developed an intragenic codominant molecular marker for the Rc gene and tested it with contrasting as to the seed colour rice varieties examined feature. The efficacy of the marker has been shown for 1142 families of rice, each sample containing 120 plants.
Effect of Unani medicine on irritant contact dermatitis: case study
Authors: Kawoosa Shahnaz Hafeez , Mushtaq Allaqaband Shafia , . Rakhshandah 
Published: September 2017

<p class="abstract"><span lang="EN-IN">Contact dermatitis is an allergic reaction of skin which occurs in response to a substance that comes in contact with surface of skin. Irritant contact dermatitis is one of the type of contact dermatitis, most frequently caused by occupational exposure either as an industrial contact or household contact. In Unani medicine, contact dermatitis has been described as an eruption on skin surface in which initially there is erythema, burning sensation followed by formation of papules along with itching on the affected site. Here we report a case study of 54 years male, working in sewage treatment plant having being diagnosed of Irritant contact dermatitis on palmer surfaces of both hands. Patient was given Unani treatment both oral as well as local and was asked for follow up every week. After 28 days of treatment patient had significant improvement with mild scales and no erythema</span><span lang="EN-IN">. </span></p>
Pattern of neck masses in adult patient in southern region KSA
Authors: Hudise Jibril Yahya 
Published: September 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Many head and neck diseases manifest as neck masses with a wide range of developmental lesions to malignancies. A neck mass can be defined as any abnormal growth or development from the skull base to the level of the clavicle. This retrospective study to assess the distribution of neck masses related to gender, age, pathology, and anatomical location of neck masses in Asir Central Hospital. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">During a 5-year period (2011–2016), the medical records of 158 patients with neck masses were collected from the department of pathology at Asir Central Hospital KSA. The cases were reviewed for data on gender, age, pathology, and the anatomical location. Comparisons between genders, age groups, and tissue origins were performed. We divided the age to 4 categories: from 15 to 30 years, 31 to 45 years, 46 to 60 years, and more than 60 years. All statistical tests were performed with SPSS software. We exclude thyroid, parathyroid and salivary gland masses. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Over a period of 5 years, a total of 158 patients (90 men and 68 women) had neck masses resected for pathological assessments. The age of presentation was ranging from 15 to 84 years. Among the 158 cases, 40.5% developed in (from 15 years to 30 years old), 24.7% developed in (31 to 45 years), 20.9% developed, in (46 to 60 years), and 13.9% developed in age more than 60 years. The histopathological diagnosis of the neck masses were congenital 10.1%, inflammatory 28.5%, benign tumor 5.7% and malignant tumor 55.7%. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">The age and location of neck masses are the most important variables. When a neck mass is seen, neoplasms should be considered in older adults inflammatory and congenital masses in children and young patients. Although the history, medical examination and additional diagnostic methods provide important information, the exact diagnosis may only be obtained by histopathological examination.</span></p>
Sovereignty and Democracy in Global Times: acutality of the Jean-Jacques Rousseau Political Philosophy and the limits of the social contract
Authors: Baccega Marcus 
Published: September 2017

SOBERANIA E DEMOCRACIA EM TEMPOS MUNDIALIZADOS: ATUALIDADE DA FILOSOFIA POLÍTICA DE JEAN-JACQUES ROUSSEAU E OS LIMITES DO CONTRATO SOCIAL

Resumo: este artigo visa a problematizar os (des)caminhos dos conceitos políticos e das práticas sociais e jurídicas em torno da soberania política do Estado Nacional e da democracia nos tempos de mundialização do Capital. Portanto, revisita e percorre uma breve arqueologia conceitual da Soberania, desde Isidoro de Sevilha até a clássica definição de Jean Bodin nos Seis Livros sobre a República (1576). O propósito é problematizar a filosofia política de Rousseau para, então, perceber e discutir seus limites suas virtualidades, bem como a atualidade de sua noção de Contrato Social e o papel da Filosofia Política na Era do Capital Global.

Palavras-chave: Rousseau. Soberania. Mundialização do Capital.

Abstract: this paper casts doubt on the ways and shunts of political concepts and social and legal practices concerning political sovereignty of the Nation State and democracy at the time of Capital’s globalization. It revisits a brief conceptual archeology of Sovereignty, since Isidore of Seville to the classical definition by Jean Bodin in The Six Books on the Republic (1576). The purpose is casting doubt on the political philosophy of Rousseau, in order to discuss its limits and virtualities, and the topicality of his notion of social contract and the role of Political Philosophy at the Age of Global Capital.
Keywords: Rousseau. Sovereignty. Globalization of Capital.
La experiencia escocesa en los referenda de devolución y secesión = The Scottish experience of devolution and secession referenda
Authors: Harvey Malcolm 
Published: September 2017

Resumen: Consultar e involucrar a la población se ha vuelto habitual en los últimos años. El Reino Unido, que no cuenta con una constitución codificada, ha utilizado el referéndum para decidir sobre diversas cuestiones constitucionales, siendo la más reciente la consulta sobre la permanencia del Reino Unido en la Unión Europea en junio de 2016. Este artículo explora la experiencia escocesa de referenda, examinando el fallido referéndum de devolución de 1979, su repetición exitosa en 1997, y el referéndum de independencia de 2014, en el que los escoceses, de forma aparentemente decisiva, decidieron quedarse en el Reino Unido. Este artículo argumenta que, aunque en cada ocasión fueron las consideraciones políticas, más que los principios, los que llevaron al uso del referéndum, defensores de la democracia directa y activistas y defensores de casos similares pueden aprender algunas lecciones de todas ellas. Palabras clave: Escocia, Referenda, Devolución, Independencia. Abstract: Consulting and engaging with the public has become vogue in recent years. The United Kingdom, without a codified constitution, has utilised the referendum to decide upon constitutional issues, with the vote to leave the European Union in June 2016 the most recent of these. This article explores the Scottish experience of referendums, examining the failed devolution referendum of 1979, the reversal of this decision in 1997, and the independence referendum of 2014, in which Scots, apparently decisively, voted to remain in the UK. This article argues that, though on each occasion political considerations rather than principle led to the use of referendums, there are lessons to be learned from each, both for proponents of direct democracy and for campaigners and activists in similar cases.Keywords: Scotland, Referendums, Devolution, Independence
Democracia republicana = Republican Democracy
Authors: Uscanga Barradas Abril 
Published: September 2017

Resumen: Este trabajo pretende explicar los orígenes e importancia del republicanismo como teoría aplicable a la democracia, así como su posible aplicación como una válvula de escape a la crisis democrática actual, pues últimamente se presentan numerosas y constantes críticas al sistema democrático imperante en nuestros días, lo que nos hace pensar en la existencia de una serie de deficiencias tanto políticas como sociales que, quizás, podrían ser subsanadas replanteando el modelo o visualizándolo desde otra perspectiva más acorde a los fines y necesidades de la sociedad contemporánea.Palabras clave: Democracia republicana, libertad como no dominación, virtudes cívicas, liberalismo, crisis democrática, Estado. Abstract: This paper aims to explain the origins and importance of republicanism as a theory applicable to democracy, as well as, its application like a scape valve of the democratic crisis that prevails today, currently, there are many criticisms of today's democratic system, which makes us think of the existence of a series of deficiencies both political and social that, maybe could be rethought or visualized from another perspective, more in line with the aims and needs of contemporary society.Keywords: Republican democracy, liberty without domination, civic virtues, liberalism, democratic crisis, State.
Gestão por temas como metódica adequada para implantação da cultura brasileira de precedentes constitucionais
Authors: Silva Christine Oliveira Peter da , Aguiar Lucas Albuquerque 
Published: September 2017

Este artigo trata da gestão por temas como uma metodologia que viabiliza a implementação da sistemática da repercussão geral. Esta, por sua vez, é um instituto próprio do Direito Processual Constitucional que pode ser apresentado como elemento precursor de uma cultura brasileira de vinculação a precedentes constitucionais. Trata-se de estudo sob a influência da teoria da dependência da trajetória e seus corolários e objetiva apresentar as razões que justificam a adoção dessa metodologia como ferramenta para dar efetividade à sistemática da repercussão geral dos recursos extraordinários perante o Supremo Tribunal Federal. A dogmática constitucional guiará o texto argumentativo, que também utilizará dados estatísticos, a fim de conduzir à conclusão de que essa sistemática deve vir associada a uma metodologia de gestão dos recursos extraordinários perante a Suprema Corte brasileira, a qual permita que se prestigie o direito material em discussão visando uma cultura brasileira de vinculação obrigatória aos precedentes constitucionais.
Evaluación de ecuaciones alométricas de biomasa epigea en una selva mediana subcaducifolia de Yucatán
Authors: Ramírez Ramírez Gustavo , Dupuy Rada Juan Manuel , Ramírez y Avilés Luis , Solorio Sánchez Francisco Javier 
Published: September 2017

Los objetivos del estudio fueron elaborar y cotejar ecuaciones alométricas para estimar la biomasa epigea (BE) en una selva mediana subcaducifolia del ejido San Agustín, Yucatán, México, y compararlas con ecuaciones existentes. Se seleccionaron 47 árboles de 18 especies con diámetros normales entre 2.5 cm y 41.5 cm. Se midió el diámetro de cada árbol y la altura se estimó antes y se midió después de derribarlo. Se obtuvo el peso fresco de cada componente (fuste, ramas, hojas) en el campo y se tomaron muestras para determinar su peso seco en el laboratorio y extrapolar a todo el individuo. Se elaboraron seis ecuaciones alométricas evaluadas a través del criterio de información de Akaike (AIC), el valor de R2 ajustado y validación cruzada. La mejor ecuación tuvo un valor de AIC de 48.36 y un R2ajustado de 0.96. La validación cruzada mostró un valor de R2 ajustado de 0.72 y un coeficiente de concordancia de 0.56. Contrario a lo esperado, esta ecuación es menos precisa que algunas otras utilizadas para las selvas de la Península de Yucatán, incluyendo ecuaciones locales y de otros continentes, con tamaños de muestra muy contrastantes. Sin embargo, la mejor ecuación elaborada en este estudio permite obtener estimaciones de la BE de las selvas medianas subcaducifolias de Yucatán adecuadas, especialmente para los individuos de mayor tamaño, que son los más influyentes.
Гострий респіраторний дистрес-синдром у дітей. Що нового?
Authors: Snisar V.I. 
Published: September 2017

Респіраторний дистрес-синдром у дітей — одна з найскладніших патологій, з якою доводиться стикатися у відділеннях реанімації та інтенсивної терапії. У педіатричній практиці були відсутні конкретні рекомендації щодо діагностики та лікування дітей різних вікових груп. Не було конкретних педіатричних дефініцій для респіраторного дистрес-синдрому дорослих. У 2015 році експертами Погоджувальної конференції з педіатричного гострого респіраторного дистрес-синдрому (ПГРДС) (The Pediatric Acute Lung Injury Consensus Conference) були опубліковані конкретні визначення по ГРДС у дітей, а також подані пріоритетні напрямки для майбутніх досліджень. Було розроблено в цілому 151 рекомендацію, що стосуються розділів, пов’язаних із педіатричним гострим респіраторним дистрес-синдромом: визначення, поширеність та епідеміологія; патофізіологія, супутні захворювання та тяжкість; респіраторна підтримка; легенева, допоміжна і нелегенева терапія; моніторинг; неінвазивна респіраторна підтримка та вентиляція; екстракорпоральні методи лікування; захворюваність і довгострокові результати. У цій статті надані основні розроблені рекомендації та конкретизований ряд позицій, що мають особливості тільки для педіатричного ГРДС. До того ж, визначено ряд відмінностей між гострим респіраторним дистрес-синдромом дорослих та дітей як в його діагностиці, так і в лікуванні. При оцінці оксигенації, рівня гіпоксемії та визначенні тяжкості педіатричного ГРДС були прийняті такі показники, як індекс осксигенації (OI) = (FIO2 × середній тиск в дихальних шляхах (Paw) × 100) / РаО2, та індекс насичення киснем (OSI) = (FIO2 × Paw × 100) / SpO2 [11, 12]. Все це буде оптимізувати та покращувати терапію ГРДС у дітей і в подальшому знижувати показник їх смертності від цієї патології.
Острый подагрический артрит и быстропрогрессирующая почечная недостаточность как манифестация множественной миеломы: описание клинического случая
Authors: Gudym O.V. , Basovska T.S. , Mykhalska L.V. , Golovach I.Yu. , Kindrakevych O.V. 
Published: September 2017

Представлено описание клинического случая диагностики множественной миеломы у мужчины 78 лет, которая клинически дебютировала острым приступом подагры. Пациент поступил в клинику в связи с развитием первого острого приступа подагры. Приступ характеризовался полиартрикулярным поражением суставов верхних и нижних конечностей, выраженной воспалительной реакцией, недостаточным ответом на прием нестероидных противовоспалительных препаратов, а также высоким уровнем гиперурикемии. Концентрация мочевой кислоты в сыворотке крови колебалась в пределах от 636 до 712 мкмоль/л. Исследование синовиальной жидкости воспаленного коленного сустава позволило выявить кристаллы мочевой кислоты и подтвердить диагноз острого подагрического артрита. Одновременно у пациента были установлены значительные нарушения функции почек: креатинин составлял 574 мкмоль/л, мочевина — 39,9 ммоль/л, скорость клубочковой фильтрации по CKD-EPI — 8 мл/мин, суточная протеинурия — 1,8 г. Ретроспективная оценка лабораторных показателей позволила выявить совершенно нормальные показатели почечной функции 6 месяцев назад. Принимая во внимание развитие острого подагрического артрита, его полиартикулярный характер, упорное течение, быстрое вовлечение новых суставов, высокие значения уровня мочевой кислоты во время острого приступа, превышающих 600 мкмоль/л (10 мг/дл), достаточно быстрое развитие почечной недостаточности (в течение 6 месяцев) вплоть до терминальной стадии, было высказано предположение о вторичном характере подагры на фоне поражения почек другим патологическим процессом. Дальнейшие клинические, лабораторные и инструментальные исследования позволили верифицировать множественную миелому с поражением почек. Белок Бенс-Джонса в моче не определялся, не было также зафиксировано гиперпротеинемии. Однако боль в позвоночнике, ребрах и грудной клетке стала основанием для проведения рентгенологического исследования костей скелета. Были выявлены типичные изменения скелета для множественной миеломы. В миелограмме отмечено высокое содержание плазматических клеток (21,1), при електрофорезе белков крови определен высокий показатель М-градиента (30,42 %), а цитохимическое исследование костного мозга полностью подтвердило диагноз множественной миеломы. Представленный клинический случай интересен тем, что множественная миелома клинически дебютировала с острого подагрического артрита, замаскировав при этом клинические проявления поражения почек и другие симптомы.