bluuebunny/crossref_metadata_2025_split huggingface dataset:
The management of metastatic radioiodine-refractory differentiated thyroid cancer requires an integrated approach including both directed and systemic therapies
Authors: Cooray Shamil D , Topliss Duncan J 
Published: February 2017

Summary
A 58-year-old man with metastatic radioiodine-refractory differentiated thyroid cancer (DTC) presented with left thigh and right flank numbness. He had known progressive and widespread bony metastases, for which he received palliative radiotherapy, and multiple bilateral asymptomatic pulmonary metastases. CT scan and MRI of the spine revealed metastases at right T10–L1 vertebrae with extension into the central canal and epidural disease at T10 and T11 causing cord displacement and canal stenosis but retention of spinal cord signal. Spinal surgery was followed by palliative radiotherapy resulting in symptom resolution. Two months later, sorafenib received approval for use in Australia and was commenced and up-titrated with symptomatic management of mild adverse effects. Follow-up CT scan three months after commencement of sorafenib revealed regression of pulmonary metastases but no evident change in most bone metastases except for an advancing lesion eroding into the right acetabulum. The patient underwent a right total hip replacement, intra-lesional curettage and cementing. After six months of sorafenib therapy, CT scanning showed enlarging liver lesions with marked elevation of serum thyroglobulin. Lenvatinib was commenced and sorafenib was ceased. He now has stable disease with a falling thyroglobulin more than 5 years after metastatic radioiodine-refractory DTC was diagnosed.
In DTC, 5% of distant metastases become radioiodine-refractory, resulting in a median overall survival of 2.5–3.5 years. Tyrosine kinase inhibitor (TKI) therapy has recently been demonstrated to increase progression-free survival in these patients but poses some unique management issues and is best used as part of an integrated approach with directed therapy.

Learning points:

Directed therapies may have greater potential to control localised disease and related symptoms when compared to systemic therapies.

Consider TKI therapy in progressive disease where benefits outweigh risks.

Active surveillance and timely intervention are required for TKI-related adverse effects.

There is a need for further research on the clinical application of TKI therapy in advanced DTC, including comparative efficacy, sequencing and identifying responders.
Studies of an Androgen-Binding Protein Knockout Corroborate a Role for Salivary ABP in Mouse Communication
Authors: Chung Amanda G , Belone Phillip M , Bímová Barbora Vošlajerová , Karn Robert C , Laukaitis Christina M 
Published: February 2017

Abstract
The house mouse Androgen-binding protein (Abp) gene family is comprised of 64 paralogs, 30 Abpa and 34 Abpbg, encoding the alpha (ABPA) and beta-gamma (ABPBG) protein subunits that are disulfide-bridged to form dimers in secretions. Only 14 Abp genes are expressed in distinct patterns in the lacrimal (11) and submandibular glands (3). We created a knockout mouse line lacking two of the three genes expressed in submandibular glands, Abpa27 and Abpbg27, by replacing them with the neomycin resistance gene. The knockout genotype (−/−) showed no Abpa27 or Abpbg27 transcripts in submandibular gland complementary DNA (cDNA) libraries and there was a concomitant lack of protein expression of ABPA27 and ABPBG27 in the −/− genotype saliva, shown by elimination of these two proteins from the saliva proteome and the loss of cross-reactive material in the acinar cells of the submandibular glands. We also observed a decrease in BG26 protein in the −/− animals, suggesting monomer instability. Overall, we observed no major phenotypic changes in the −/− genotype, compared with their +/+ and +/− siblings raised in a laboratory setting, including normal growth curves, tissue histology, fecundity, and longevity. The only difference is that male and female C57BL/6 mice preferred saliva of the opposite sex containing ABP statistically significantly more than saliva of the opposite sex without ABP in a Y-maze test. These results show for the first time that mice can sense the presence of ABP between saliva targets with and without ABPs, and that they spend more time investigating the target containing ABP.
Interfaces de um intercâmbio de doutorado: formação de professores e experiências relevantes
Authors: Soares Elane Chaveiro 
Published: January 2017

Neste texto apresento a construção de conhecimento proporcionada pelo intercâmbio de Doutorado realizado na cidade de La Plata/Argentina, a partir do convênio entre a Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) e a Universidade Nacional de La Plata (UNLP)/financiado pela CAPES. Pude estudar por três meses (agosto a outubro/2011) nesta universidade e participar ativamente de quatro importantes atividades realizadas neste período. Primeiro como ouvinte do VIII Encuentro de Cátedras de Pedagogía de Universidades Nacionales. Segundo, como colaboradora do 1º Simposio de Enseñanza de la Química e como aluna do Seminário de Politicas de Formacíon, Currículum e Identidades Docentes ministrado pela professora Ms. Flavia Terigi. E finalmente, como apresentadora de comunicação oral no I Congreso Internacional de Enseñanza de las Ciencias y Matemática y II Encuentro Nacional de Enseñanza de la Matemática.O relatório foi escrito a partir da construção de conhecimento na complexidade vivencial das discussões propostas, do referencial teórico utilizado nesta universidade, do profícuo envolvimento com o corpo docente e discente do Departamento de Ciências Exactas y Naturales da Facultad de Humanidades da UNLP, além da imersão realizada em outra cultura, com outra língua e outros enfrentamentos. O engajamento proposto para a realização deste intercâmbio foi essencial na conquista de aprendizagens relacionadas ao Ensino de Química e à Formação de Professores junto a nossos hermanos. A realização de um Doutorado em Educação pressupõe, dentre outras coisas, a superação de lutas concorrenciais por domínio de espaço e de voz com interfaces cada vez mais entrelaçadas.
PUCRS e Newcastle University: uma experiência de internacionalização a partir da construção de uma exposição conjunta entre o Museu de Ciências e Tecnologia e o Great North Museum: Hancock
Authors: Ferraro José Luís Schifino , Simões Pires Melissa Guerra , Shinkai Rosemary Sadami Arai 
Published: January 2017

O presente artigo tem como objetivo apresentar a parceria estabelecida entre a Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) e a Newcastle University (NU) para a elaboração conjunta de uma exposição sobre Evolução. Essa aproximação entre o Museu de Ciências e Tecnologia da PUCRS (MCT-PUCRS) e o Great North Museum: Hancok (GNM) possibilitou uma abertura para que ambas universidades estreitassem suas relações e para a elaboração de estratégias e ações para internacionalização. Ao propor um trabalho conjunto – concepção, planejamento e troca de expertises – sobre o tema, optou-se pela utilização das coleções científicas de ambos museus para o ensino da evolução no sentido de promover uma melhor compreensão das modificações climáticas sob uma perspectiva ecomuseológica.
Internacionalização da educação superior: uma análise comparativa documental entre duas instituições privadas e comunitarias da região sul do Brasil
Authors: Guilherme Alexandre Anselmo , Herbertz Dirce Hechler , Morosini Marília Costa 
Published: January 2017

Este estudo apresenta a análise documental sobre o processo de internacionalização da Educação Superior em duas universidades privadas e comunitárias, uma do RS e outra do PR, ambas sem fins lucrativos, tendo sua confessionalidade baseada nos princípios Maristas: a PUCRS e a PUCPR. O objetivo foi analisar a importância das relações entre o processo de internacionalização da educação superior e os princípios que fundamentam os Projetos Políticos Institucionais utilizando o referencial teórico de Audy (2006) e Morosini (2006). Trata-se de uma pesquisa qualitativa na medida em que se reflete sobre as políticas internas, os dados apresentados e quantitativa ao trazermos para a discussão dados numéricos das referidas instituições no âmbito nacional e internacional. A fonte de dados foram os documentos institucionais como o Plano Estratégico – PE e o Plano Pedagógico Institucional – PPI; dados do CNPq, CAPES, RUF, The Times e QS. Como resultados desta pesquisa, pode-se apontar para um redimensionamento das organizações institucionais da Educação Superior no que se refere ao desenvolvimento tecnológico, a um projeto global de desenvolvimento humano.
Influence of Oxygen Addition and Substrate Temperature on Textured Growth of Al-Doped ZnO Thin Films Prepared by RF Magnetron Sputtering
Authors: Kuppusami P. , Diesner K. , Sieber I. , Ellmer K. 
Published: January 2017

AbstractSputtering of aluminium doped zinc oxide thin films from a ceramic ZnO:Al target requires a controlled addition of oxygen to the sputtering atmosphere in order to obtain films with low resistivity and high transparency. In this paper the influence of the oxygen addition and of the substrate temperature on the structural, morphological and electrical properties of ZnO:Al films is investigated. The oxygen addition leads to a minimum resistivity when the oxygen content during sputtering is 0.2%. This small amount of oxygen not only improves the transparency of the films, it also induces to a significant grain growth as revealed by scanning electron microscopy. A further increase of the oxygen content leads to highly resistive films, due to a complete oxidation of the dopant Al. As expected, higher substrate temperatures from about 373 to 673 K improve the of crystallinity and hence the resistivity. The lowest resistivity achieved was about 1.2.10-3 Ωcm. At still higher temperatures the resistivity increases which seems to be due to an outdiffusion of sodium into the ZnO:Al films from the soda lime glass, compensating part of the donors.
Bulk Versus Surface Magnetic Texture in Thin Films Obtained by Pulsed Laser Deposition
Authors: Sorescu Monica , Grabias A. , Tarabasanu-Mihaila D. , Diamandescu L. 
Published: January 2017

AbstractIn this paper we present a direct comparison between the properties of bulk magnetic systems and those of corresponding thin films obtained by pulsed laser deposition. These are: Fe50Co50, Fe3O4, Fe3O4:Co and Fe2O3:Cr. Using transmission and conversion electron Mössbauer spectroscopy, we present results on the bulk and surface hyperfine magnetic fields, site populations and magnetic texture. Our results support an increase in the hyperfine field values at surfaces, a more pronounced out-of-plane magnetic texture in the films, as well as a perfect transfer of stoichiometry and substitution level from target to substrate materials.
KEBIASAANMAKAN DANBIOLOGI REPRODUKSI IKANMOTAN (Thynnichthys polylepis) DIWADUK KOTOPANJANG, RIAU
Authors: Asyari Asyari , Fatah Khoirul 
Published: February 2017

Ikan motan (Thynnichthys polylepis) merupakan jenis ikan yang mempunyai nilai ekonomi yang cukup penting di Kabupaten Kampar. Ikanmotan diWaduk Kotopanjang termasuk jenis ikan yang dominan dan digemarimasyarakat. Penelitian ini untuk mendapatkan data dan informasi mengenai kebiasaan makan dan biologi reproduksi dilakukan pada bulan Agustus sampai Nopember 2009. Penelitian ini dilakukan melalui metode survei dengan pengambilan contoh dilakukan secara purposive sampling. Untuk mengetahui kebiasaan makan digunakan metode Indeks Preponderan, kematangan gonad diamati secara morfologi dan penentuan fekunditas dihitung dengan metodegravimetrik. Hasil penelitian inimenunjukan bahwa ikan motan tergolong jenis ikan herbivora dengan pakan utama makrofita 49,9%, pakan pelengkapnya adalah phytoplankton 22,6% dan detritus 17,4%, dan pakan tambahan terdiri atas protozoa 0,8%, rotifera 0,5%, dan crustaceae 0,4%. Selain itu makanan yang tak teridentifikasi 8,4%. Ikan motan memijah secara bertahap (parsial) dimulai pada bulan Nopember. Fekunditas ikan motan berjumlah antara 25.360-61.198 butir dengan diameter telur pada kisaran antara 0,31-0,90mm, serta indeks kematangan gonad antara 6,65-17,56%. Motan (Thynnichthys polylepis) is one of fish species having the economically important value in Kampar Regency. In Kotopanjang Reservoir motan is a kind of fish which is dominant and it is liked by the people. The objectives of the research were to get data and information of food habit and the biology reproduction such as gonadal maturity, fecundity, and egg diameter has been carried out on August to November 2009. The research is done with the survey method, meanwhile the samples taken by purposive sampling. Food habit can used an index of preponderance method, the gonadal maturity is used by the morphology, meanwhile fecundity is counted by gravimetric. The result of the research shows that motan is belong to a herbivore fish with a mean food macrophyta of 49.9% as a mean food, phytoplankton of 22.6% and detritus of 17.4% as complement food. Meanwhile the addition food such as protozoa of 0.8%, rotiferas of 0.5%and crustaceae of 0.4%. Beside that, the unidentify part is 8.4%. Motan spawning by partial which is started on November. Fecundity of motan shows that the total egg varied between 25,360-61,198 with egg diameter is between 0.31-0.90 mm. Meanwhile index maturity of gonads is between 6.15-17.56 %. Based on the aspects some water quality.
EFISIENSI PEMANFAATANENERGICAHAYAMATAHARIOLEHFITOPLANKTON DALAMPROSES FOTOSINTESISDIWADUKMALAHAYU
Authors: Warsa Andri , Purnomo Kunto 
Published: February 2017

Cahaya matahari merupakan sumber energi utama yang menentukan produktivitas suatu ekosistem akuatik. Ketersediaan cahaya akan menentukan kecepatan fotosintesis yang akan menentukan kecepatan pertumbuhan produsen primer. Tujuan penelitian ini adalah untuk mengetahui efisiensi pemanfaatan cahaya matahari oleh fitoplankton di Waduk Malahayu. Penelitian ini dilakukan di Waduk Malahayu, Kabupaten Brebes, Jawa Barat, pada bulan Oktober 2010. Pengamatan produktivitas primer kotor, kelimpahan fitoplankton, intensitas cahaya, dan klorofil-a dilakukan pada dua stasiun yaitu stasiun keramba jaring apung dan dam pada kedalaman 0,5; 2; dan 4 m dengan metode survei berstrata. Pengukuran produktivitas primer kotor dilakukan dengan metode botol gelap dan terang. Hasil penelitian menunjukkan nilai produktivitas primer kotor diWadukMalahayu berkisar 45,6-121,9 mgC/jamdan konsentrasi klorofil-a berkisar 3,7-11,8mg/m3. Kelimpahan individu fitoplankton diWaduk Malahayu berkisar 100,6-112,67 ind./l dengan genera yang dominan adalah Oscillatoria (Cyanophyceae) dan Peridinium (Dinophyceae). Efisiensi penggunaan cahaya matahari oleh fitoplankton di Waduk Malahayu berkisar 0,5-2,7%. Efisiensi cahaya matahari menurun dengan bertambahnya kedalaman air. Sunlight is primary energy resource that determine the productivity of aquatic ecosystem. Its availability will determines the photosynthetic rate and primary producer growth rate. Study in order to know thr effeciency of sunlight uptake by phytoplankton inMalahayu Reservoir, Brebes Regency, Central Java in October 2010. Sampling were for gross primary productivity, phytoplankton abudance, light intensity, and chlorophyll-a carried at two stations, keramba jaring apung and dam and at three water depth, surface, 2 and 4 m with stratified sampling method. Measurement of gross primary productivity was conducted with dark and ight botle method. Gross primary productivity ranged from 45.6-121.9 mgC/hr with chlorophyll-a concentration between 3.7-11.8 mg/m3. Phytoplankton abundance ranged from 10.06-112.67 ind./l with Oscilatoria and Peridinium as dominant genera. Efficiency of sunlight uptake by phytoplankton ranged from 0.5-2.7% and its value decreased along with an increasing water depth.
Detection of protozoal Trichomonas vaginalis and abnormal vaginal flora in high vaginal smear
Authors: Sheela Wills G. , Vijayalakshmi P. , Mohanambal . , Dharishini Deepa 
Published: January 2017

Background: Vagina is the fibro muscular membrane sheath communicating with the uterine cavity and to the exterior at the vulva. Infection of female genital tract results from vaginal flora, extraneous agents and sexually transmitted diseases. The objective of the study was: a) high vaginal smear screening to find out incidence of abnormal vaginal flora of micro-organisms, b) prevalence of protozoal Trichomonas vaginalis.Methods: Rural women from in and around Ammapettai in the age group of 20-50 years attending Gynaecology OPD of SSSMC&RI for vaginal discharge and itching vulva. Exclusion criteria were age less than 20 and above 50 and pruritis vulva due to other causes the study size comprised of 50 women. After getting Institutional ethical committee’s approval and written informed consent from the patients, detailed history regarding type of discharge, odour, itching, and associated bleeding was taken. Per speculum and per vaginal examination done. High vaginal smear for aerobic bacterial profile and Trichomonas infection were taken and transported to microbiology laboratory for staining and culture. Wet mount microscopic examination of Trichomonas vaginalis and Candidiasis with saline and KOH mount done.Results: Out of 100 smears 9 were normal vaginal flora organisms, aerobic pathogens 43%, Trichomonas vaginalis (TV) 30%, and Candida albicans 5% mixed infections on 7 smears. E. coli was seen in 23 samples, Klebsiella in 14, Pseudomonas aeroginosa 4, Staphylococcus in 6 samples. Gram negative organisms were 100% sensitive to imipenem, amikacin and gentamycin and 100% resistant to cefazolin, 80% to ceftazidime, 74% to cefotaxime. Gram positive staphylococcus 50% were resistant to gentamycin, ampicillin.Conclusions: This study reflects on our responsibility to create awareness among women regarding abnormal vaginal discharge through proper health education routine screening targeted treatment to envisage healthy quality life.
Comparative study of maternal and fetal outcome between low and normal amniotic fluid index at term
Authors: Mathuriya Gayatri , Verma Megha , Rajpoot Sudha 
Published: January 2017

Background: Amniotic fluid index (AFI) is kind of an estimate of the amount of amniotic fluid. It is an index for the fetal well-being. The aim was to study fetal and maternal out come in cases of low AFI and normal AFI.Methods: This was a case control prospective comparative study performed on 200 randomly selected low risk pregnant patients at term (37-40 weeks of gestation) admitted in Obstetrics and Gynaecology Department. 100 patients with AFI <5 cm (cases) and 100 patients with AFI 8-20 cm (control).Results: Increased number of LSCS in cases that is 35 while only 10 in control and almost equal incidences of MSL and FD in both the groups, while in cases 17 women were planned for elective LSCS for various indications in expectation of better fetal outcome. There was significant low APGAR score in babies of cases, but clinically we refute this. In present study almost double the no. of babies in cases was IUGR or FGR. Significant association between low AFI and congenital anomalies in babies. Most of the anomalies were of urinary tract system.Conclusions: An AFI ≤5 cm detected at term that was at or after 37 completed weeks of gestation in a low risk pregnancy was an indicator of poor perinatal outcome. Oligohydramnios was being detected more frequently now-a-days due to ready availability of ultrasonography these days.
Clinico epidemiological study of blunt abdominal trauma in a tertiary care hospital in north western Himalayas
Authors: Malhotra Parikshit , Sharma Dhruv , Gupta Sanjiv , Minhas S. S. 
Published: January 2017

Background: Blunt abdominal trauma (BAT), a common form of trauma, is one of the major causes of morbidity and mortality. The study was aimed at the study of spectrum of injuries to various intra-abdominal organs after blunt trauma and to ascertain cause/mode of BAT in a hospital of hilly locality of Shimla.Methods: A prospective study was designed to conduct in the department of Surgery, IGMC, Shimla, India during the period of one year from 1st June 2005 to 31st May 2006. A total of 30 patients who had sustained BAT with or without other associated injuries were selected. In all patient’s history was taken and detailed physical examination done while concomitant resuscitation was performed. Chest and abdominal radiographs were done in all patients.Results: BAT is a major cause of morbidity and mortality especially in young people in the 11-40 years’ age group. Males are affected more than females. Road traffic accidents are the predominant mode of injury however, a relatively high incidence of blunt abdominal trauma due to falls is observed in a hilly state like ours. Spleen and liver are the two commonly injured organs after blunt abdominal trauma.Conclusions: Proper early diagnosis with initial and adequate resuscitation is beneficial in having a good outcome in patients of BAT.
Pakan Ikan Alternatif Berbahan Baku Lokal untuk Calon Induk Ikan Gurami (Osphronemus gouramy)
Authors: Marnani Sri , Pramono Taufik Budhi 
Published: January 2017

The aims of this study was to get local raw material of feed fish able to improve growth anddevelopment of gonads and composition of the artificial feed and feed supplement that can improvethe reproductive performance of gouramy fish. The method used is the method of completelyrandomized. The research was used completly randomized design with four treatments and fourrepetition. The treatmens tested were four kinds, pellet commercial (60%) additional sprouts mungbean (Phaseolus radiatus L), fruit peel papaya (Carica papaya) and cabbage (Brassica oleracea L) by40%, and a pelleted commercial (100%) as control. Absolute growth ranges from 6-425 g, the relativegrowth of 3.7 to 22.1%, the growth day 1-7,1 g / day, feed efficiency from 7.8 to 29.33%, GSI 0.1 to1.1% and HSI 0.8 to 1.7%. Temperatures ranging from 23- 31,5⁰C, pH 6.6 to 7.5, Oxygen 5.0 - 6.2ppm , ammonia 0 - 0.25 ppm. Supplemental feed mixture (40%) and commercial pellets (60%) canimprove the growth and reproductive performance brood gouramy. Results of measurement oftemperature, pH and ammonia still qualify live gouramy.Keywords : alternative fish feeds, brood, Osphronemus gouramy