bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supratentorial Glioblastoma With Spinal Cord Intramedullary Metastasis
Authors: Hamilton Mark G. , Tranmer Bruce I. , Hagen Neil A. 
Published: February 2016

ABSTRACT:A patient presented with myelopathy due to intramedullary thoracic spinal cord glioblastoma 10 months after treatment for a supratentorial glioblastoma. There was no supratentorial recurrence, and no evidence of gross leptomeningeal dissemination documented by CSF cytology, complete myelography, and MR1 imaging. Gross examination of the spinal cord and arachnoid at the time of exploratory thoracic spinal surgery was normal. However, histological review of thoracic arachnoid demonstrated microscopic deposits of glial fibrillary acidic protein (GFAP) positive tumour consistent with malignant astrocytoma. Intramedullary spinal cord metastasis of cerebral glioblastoma rarely occurs, but may develop in association with leptomeningeal tumour dissemination. As local control of primary tumours improves, distant metastasis is likely to become a more common clinical problem. Leptomeningeal gliomato-sis may be very difficult to document, even when clinically suspected and GFAP staining of a biopsy of arachnoid tissue can play an important role in confirming the diagnosis. This information can be critical to establish prognosis and develop an appropriate treatment strategy.
Physiology of Basal Ganglia Disorders: An Overview
Authors: Hallett Mark 
Published: February 2016

ABSTRACT:The pathophysiology of the movement disorders arising from basal ganglia disorders has been uncertain, in part because of a lack of a good theory of how the basal ganglia contribute to normal voluntary movement. An hypothesis for basal ganglia function is proposed here based on recent advances in anatomy and physiology. Briefly, the model proposes that the purpose of the basal ganglia circuits is to select and inhibit specific motor synergies to carry out a desired action. The direct pathway is to select and the indirect pathway is to inhibit these synergies. The clinical and physiological features of Parkinson's disease, L-DOPA dyskinesias, Huntington's disease, dystonia and tic are reviewed. An explanation of these features is put forward based upon the model.
Severe Permanent Encephalopathy in Acute Lymphoblastic Leukemia
Authors: Bernard L. Maria , Maureen Dennis , Marc Obonsawin 
Published: February 2016

ABSTRACT:As survival rates for childhood acute lymphoblastic leukemia have increased, concerns over improved quality-of-life have also increased. Although 3-10% of children may experience acute transient neurotoxicity during induction chemotherapy, they are felt to be at low risk for late sequelae. We report three previously healthy boys with newly-diagnosed acute lymphoblastic leukemia who presented with obtundation and severe seizures during late induction with a standard four drug chemotherapy regimen. While all three are disease-free survivors, they unexpectedly have persistent and medically intractable partial complex seizures, broad-based neuropsychological impairment and striking neuroimaging abnormalities. These findings suggest that children with leukemia who develop an acute encephalopathy during induction chemotherapy are at risk for long-term neurological and neuropsychological sequelae, despite the cessation of further potentially neurotoxic therapy.
Intraventricular Alpha Interferon Therapy for Rasmussen’s Syndrome
Authors: Bernard L. Maria , Debbie M. Ringdahl , Mickle J. Parker , Linda J. Smith , Peter D. Reuman , Robin L. Gilmore , Walter E. Drane , Ronald G. Quisling 
Published: February 2016

ABSTRACT:A 4-year-old boy developed Rasmussen’s syndrome and was treated with alpha interferon intraventricularly. An improvement in the epileptic and neurologic syndrome was noted for several weeks following interferon. No adverse side effects were encountered. Since hemispherectomy is the only established therapy in Rasmussen’s Syndrome, further studies are needed to establish if intraventricular alpha interferon may halt the clinical progression of the syndrome.
Glutamate Dehydrogenase Deficiency in Cerebellar Degenerations: Clinical, Biochemical and Molecular Genetic Aspects
Authors: Andreas Plaitakis , Panayiotis Flessas , Anastasia B. Natsiou , Shashidharan P. 
Published: February 2016

ABSTRACT:Glutamate dehydrogenase (GDH), an enzyme central to glutamate metabolism, is significantly reduced in patients with heterogenous neurological disorders characterized by multiple system atrophy (MSA) and predominant involvement of the cerebellum and its connections. In human brain, GDH exists in multiple isoforms differing in their isoelectric point and molecular mass. These are differentially reduced in quantity and altered in catalytic activity in patients with clinically distinct forms of MSA, thus suggesting that these GDH isoproteins are under different genetic control. Dysregulation of glutamate metabolism occurs in patients with GDH deficiency and is thought to mediate the disease’s neurodegeneration via neuroexcitotoxic mechanisms. This possibility is supported by additional data showing that glutamate binding sites are significantly decreased in cerebellar tissue obtained at autopsy from MSA patients. At the molecular biological level, several cDNAs specific for human GDH have been isolated recently and cloned. Northern blot analysis of various human tissues, including brain, has revealed the presence of multiple GDH-specific mRNAs. In addition, multiple GDH-specific genes are present in humans and these data are consistent with the possibility that the various GDH isoproteins are encoded by different genes. These advances have laid the groundwork for characterizing the human GDH genes and their products in health and disease.
Dysphagia in Ambulant Patients with Parkinson's Disease: common, not dangerous
Authors: Wintzen Axel R. , Badrising Umesh A. , Roos Raymund A.C. , Vielvoye Jan , Liauw Lishya , Pauwels Ernest K.J. 
Published: February 2016

ABSTRACT:To assess the frequency of subjective and objective dysphagia and its possible pulmonary sequelae, we prospectively studied 22 out-patients with Parkinson's disease; 15 spouses served as controls. All subjects answered a standard questionnaire concerning swallowing and respiratory functions and underwent barium swallow videofluoroscopy. Possible pulmonary infection was investigated by recordings of body temperature, ESR, leucocyte count, and chest X-ray. Patients had significantly more symptoms than controls, especially choking, piece-meal deglutition and regurgitation. Videofluoroscopy revealed tracheal aspiration in one patient, vestibular aspiration in one patient and in one control. Non-fluent swallowing movements were common in patients: abnormal bolus formation, delayed swallowing reflex, vallecular stasis, and piriform sinus residue. None of the subjects had signs of pulmonary infection. Both subjective and objective oro-pharyngeal dysfunction is frequent in ambulant Parkinson patients, but apparently does not produce demonstrable pulmonary infection.
Alcoholic Dementia
Authors: Victor Maurice 
Published: February 2016

Abstract:At least four distinct cerebral diseases — Wernicke-Korsakoff, Marchiafava-Bignami, pellagrous encephalopathy, and acquired hepatocerebral degeneration — have a close association with chronic alcoholism. Each is characterized by a distinctive pathologic change and a reasonably wellestablished pathogenesis; in each the role of alcohol in the causation is secondary. The question posed in this review is whether there is, in addition to the established types of dementia associated with alcoholism, a persistent dementia attributable to the direct toxic effects of alcohol on the brain — i.e., a primary alcoholic dementia. The clinical, psychologic, radiologic, and pathologic evidence bearing on this question is critically reviewed. None of the evidence permits the clear delineation of such an entity. The most serious flaw in the argument for a primary alcoholic dementia is that it lacks a distinctive, well-defined pathology, and it must remain ambiguous until such time as its morphologic basis is established.
Between magnificence and monstrosity: Turkishness in recent popular cinema
Authors: Suner Asuman 
Published: February 2016

AbstractThis paper studies the idea of Turkishness as one thematic element that commonly characterizes recent Turkish box-office champions. The preoccupation with the idea of Turkishness in recent popular cinema can be seen as a reflection of Turkish society's bafflement with the process of rapid and intensive transformation during the 2000s. In this period, Turkish society has grown increasingly confused about how to assess its own worth in the contemporary world. The paper makes use of the terms “magnificence” and “monstrosity” to make sense of the excessive representations of Turkishness in Turkish box-office champion action films and comedies of the second half of the 2000s. The term “magnificence” stands for aspirations in Turkish society during the last decade about the revival of the glory of the Ottoman past and becoming a powerful actor again on the world scene. The term “monstrosity” is employed in relation to Turkish society's cynical indifference to the violence perpetrated by the Turkish state, which is often rendered acceptable through the presumption of “Turkish peculiarity.” The paper points to the continuity between recent blockbuster action films and comedies in their representations of Turkishness by suggesting that magnificence and monstrosity appear in these films as two sides of the same coin.
Rushing toward currency convertibility
Authors: Gemici Kurtuluş 
Published: February 2016

AbstractIn 1989, Turkey became one of the first—and few—emerging economies to fully liberalize its capital account. Given the adverse macro-economic conditions before the reforms, it is puzzling that Turkish policy-makers implemented policies amounting to a comprehensive and imprudent capital account liberalization. Using in-depth interviews with a significant number of key decision-makers behind capital account liberalization and employing archival material from news sources on the debates surrounding the reform process, this article examines the policy objectives and rationale behind the Turkish capital account liberalization. The main argument is that capital account liberalization represented a political rationality that put a premium on short-term expansion through funds from the rest of the world. This liberalization was a policy response to decreasing rates of economic growth and demands from organized labor and public employees for better working conditions and higher wages. Thus, this article shows that these distributional conflicts and the trajectory of economic growth were important determinants of the timing and scope of capital account liberalization in Turkey.
Economic institutions and institutional change in Turkey during the neoliberal era
Authors: Atiyas İzak 
Published: February 2016

AbstractIn the last three decades, the Turkish economy has become much more open and market-oriented. This paper provides an account of the changes in the underlying economic institutions that have accompanied this transformation. In particular, it assesses whether or not new economic institutions have emerged that constrain the discretionary powers of the executive in the area of economic policy and whether institutional change has resulted in a more rule-based and transparent policy framework. The story that broadly emerges is that the first two decades of the neoliberal era were predominantly a period of increased discretion at the expense of rules. By contrast, after the crisis of 2000-2001 one witnesses a substantial delegation of decision-making power to relatively independent agencies, and the establishment of rules that constrain the discretion of the executive. But this transformation is not uniform across sectors, and there are divergences between the de jure rules and their de facto implementation. Moreover, there are also examples that do not fit the general trend, especially in the case of the construction industry. Finally, recent signs suggest that the government may be having second thoughts about the “excessive” independence of regulatory and policy making bodies.
Gülümser's Story: Life History Narratives, Memory and Belonging in Turkey
Authors: Neyzi Leyla 
Published: February 2016

Herkesin bir tarihi var.Herkesin bir dili.Ne anlatır sizeyalnızlıkBana, beni.Ne anlatır sizeölümBana, kederli annemi.Dokunsak ışığa…Silinse yüzlerimiz.Ah o gözlerimiz.Gözlerimiz.-Kemal KahramanA small, dark office in the basement floor of an apartment building in Taksim. The sound of traffic filtering in from the busy street outside. Color photographs tacked to a wall next to a secretary's desk: two young girls in red posing in the lush grass, with mountains in the background. These are the two worlds of Gülümser Kalık. One, the workaday world of the center city. The other, a small village in eastern Turkey. Memories and the dream of return.
Relocating Dersim: Turkish State-Building and Kurdish Resistance, 1931–1938
Authors: Watts Nicole 
Published: February 2016

According to the deputy chief of the General Staff and other Turkish officers, it is hoped eventually to make the Tunçeli [Tunceli] region into a “second Switzerland,” as it is extremely beautiful. It appears to me, however, that its inaccessibility and the difficulties which visitors experience while travelling in Turkey will be considerable obstacles to the realisation of this dream.A. Ross, Military attaché to the British representative in Turkey, 5 September 1938
Nationalist Dilemmas: Halide Edib on Greeks, Greece, and the West
Authors: Tsakiridou Cornelia (Corinna) A. 
Published: February 2016

O College dear, we praise theeFor pointing to the starsWith faith and hope unswervingWhich no weak vision marsThy service unrestrictedBy race or class or creed;Thy love so freely offered,Its only claim-our need.-Anthem of the American College for Girls, IstanbulHalide Edib (1883-1964) was one of modern Turkey's most celebrated women. Author, feminist, nationalist, modernist, educator, and member of the National Assembly, she identified her person and career with the transformation of Turkey into a modern secular republic. Educated in the internationalist spirit of the American College for Girls in Istanbul, she was, throughout her life, a cosmopolitan intellectual with an international audience. Edib's personal transition from Ottoman society to the new nationalist elite, and her homeland's transition from empire to republic, posed no insurmountable historical, social, and cultural discontinuities; hers was a nationalism that, although grounded in Western notions of emancipation and self-determination, asserted with confidence its distinct identity and autonomy from the West.
Conduct, Meaning and Inequality in an İstanbul Courthouse
Authors: Koğacıoğlu Dicle 
Published: February 2016

AbstractThis essay seeks to analyze the daily reproduction of inequalities in and around a contemporary İstanbul civil courthouse. Based on an ethnographic study in three poor urban neighborhoods and their civil courthouse, I examine the mode of conduct in the latter and the ways in which this mode is perceived. This study shows that routinized divergences from formalistic premises in the courthouse are not perceived as flaws, but placed within informal relations. This enmeshing of formal and informal practices is considered normal by both the legal professionals and lay low-income litigants. These constituencies, however, perceive this conduct rather differently in relation to their own and others' attributes. Lay low-income litigants locate it within a broader idiom of “doing administration,” a series of tactics to engage within a horizon of perpetual injustice. For legal professionals, on the other hand, the daily mixing of formal and informal practices has to do with their mission of “educating” and transforming those in need to participate in the culture of the state. I discuss the particular relation of these two perceptions in normalizing the view of the law as a site, not of formal egalitarianism, but of hierarchical social engagements.
Politics of place/space: The spatial dynamics of the Kurdish and Zapatista movements
Authors: Gambetti Zeynep 
Published: February 2016

AbstractThis paper explores two examples of collective action, the Zapatista movement in Chiapas, Mexico, and the Kurdish movement in Turkey, by focusing on how these movements constructed two particular places, Diyarbakir and Chiapas, after the armed conflict subsided. My first aim is to show how this place-making has affected the discourses and practices of these movements. I argue that place-making is not only about locality or physical setting, but also about constructing a movement and a form of struggle in its own right. My second aim is to discuss the broad outlines of what may be called the “appropriation of space.” This refers not only to the spaces of visibility and solidarity opened up by a movement, but also to its chances of acquiring significance within local, national or global spaces of power. I look at how the Kurdish movement has had an impact on democracy in Turkey and compare it with the Zapatista movements local and transnational effects. I do so by relating physical and metaphorical notions of space to several concepts generated by social movement literature. As such, this study intends to contribute to spatial understandings of collective action. It is also likely to indicate various pitfalls and obstacles for emancipatory social movements in the present neoliberal era.
“One of the most spectacular lawsuits ever launched”: Abdülhamid's heirs, his lands and the land case in Palestine, 1908-1950
Authors: Kark Ruth , Frantzman Seth J. 
Published: February 2016

AbstractThis paper is a sequel to Fischel and Kark's study on the private lands owned by Sultan Abdülhamid II (1842-1918, ruled 1876-1909) in Palestine and analyzes their fate after his forced abdication. In particular, we examine the court cases that arose around these lands, cases which were initiated by his heirs after 1920. For 28 years the heirs, led by his eldest son, Mohammad Selim and his daughter Amina Namika, approached half a dozen governments in the Middle East and Europe to regain the properties they claimed. The appeals represented a test of the British colonial legal system as well as issues of land settlement and the role of foreign courts in interpreting Turkish and Ottoman law. We furthermore examine the disposition of the sultan's lands from his abdication in 1909 to the last attempts by his heirs to recover them from the State of Israel in 1950, the general context of his lands in the Middle East as a whole, and the legal precedent set by the Mandatory Palestine court cases.
Feminization of poverty: Does it really exist in Turkey?
Authors: Gökovalı Ummuhan , Danışman Aysun 
Published: February 2016

AbstractThis paper discusses two issues, the first being whether “feminization of poverty” in Turkey exists at all, and the second the reasons behind the feminization of poverty. The Household Budget Survey (HBS) for the years 2004 and 2006 serves as data to investigate similarities and contrasts between men and women in terms of poverty and other socioeconomic and demographic factors. Furthermore, econometric estimation techniques (logit and probit) have been employed to find out the determinants of poverty for men and women separately and together. Findings indicate that feminization of poverty does indeed exist in Turkey; however, a number of social, economic and demographic factors are universal determinants of poverty indifferent to sex.
Electron-lattice interactions strongly renormalize the charge-transfer energy in the spin-chain cuprate Li2CuO2
Authors: Johnston Steve , Monney Claude , Bisogni Valentina , Zhou Ke-Jin , Kraus Roberto , Behr Günter , Strocov Vladimir N. , Málek Jiři , Drechsler Stefan-Ludwig , Geck Jochen , Schmitt Thorsten , van den Brink Jeroen 
Published: February 2016

AbstractStrongly correlated insulators are broadly divided into two classes: Mott–Hubbard insulators, where the insulating gap is driven by the Coulomb repulsion U on the transition-metal cation, and charge-transfer insulators, where the gap is driven by the charge-transfer energy Δ between the cation and the ligand anions. The relative magnitudes of U and Δ determine which class a material belongs to, and subsequently the nature of its low-energy excitations. These energy scales are typically understood through the local chemistry of the active ions. Here we show that the situation is more complex in the low-dimensional charge-transfer insulator Li2CuO2, where Δ has a large non-electronic component. Combining resonant inelastic X-ray scattering with detailed modelling, we determine how the elementary lattice, charge, spin and orbital excitations are entangled in this material. This results in a large lattice-driven renormalization of Δ, which significantly reshapes the fundamental electronic properties of Li2CuO2.
Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region
Authors: Saintamand Alexis , Vincent-Fabert Christelle , Garot Armand , Rouaud Pauline , Oruc Zeliha , Magnone Virginie , Cogné Michel , Denizot Yves 
Published: February 2016

AbstractThe IgH 3’ regulatory region (3’RR) controls class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The mouse 3’RR contains four enhancer elements with hs1,2 flanked by inverted repeated sequences and the centre of a 25-kb palindrome bounded by two hs3 enhancer inverted copies (hs3a and hs3b). hs4 lies downstream of the palindrome. In mammals, evolution maintained this unique palindromic arrangement, suggesting that it is functionally significant. Here we report that deconstructing the palindromic IgH 3’RR strongly affects its function even when enhancers are preserved. CSR and IgH transcription appear to be poorly dependent on the 3’RR architecture and it is more or less preserved, provided 3’RR enhancers are present. By contrast, a ‘palindromic effect’ significantly lowers VH germline transcription, AID recruitment and SHM. In conclusion, this work indicates that the IgH 3’RR does not simply pile up enhancer units but also optimally exposes them into a functional architecture of crucial importance.
High-Performance Flexible Solid-State Carbon Cloth Supercapacitors Based on Highly Processible N-Graphene Doped Polyacrylic Acid/Polyaniline Composites
Authors: Wang Yongguang , Tang Shaochun , Vongehr Sascha , Ali Syed Junaid , Wang Xiangyu , Meng Xiangkang 
Published: February 2016

AbstractImproving the solubility of conductive polymers to facilitate processing usually decreases their conductivity and they suffer from poor cycling stability due to swelling-shrinking during charging cycles. We circumvent these problems with a novel preparation method for nitrogen-doped graphene (NG) enhanced polyacrylic acid/polyaniline (NG-PAA/PANI) composites, ensuring excellent processibility for scalable production. The content of PANI is maximized under the constraint of still allowing defect-free coatings on filaments of carbon cloth (CC). The NG content is then adjusted to optimize specific capacitance. The optimal CC electrodes have 32 wt.% PANI and 1.3 wt.% NG, thus achieving a high capacitance of 521 F/g at 0.5 F/g. A symmetric supercapacitor made from 20 wt.% PANI CC electrodes has more than four times the capacitance (68 F/g at 1 A/g) of previously reported flexible capacitors based on PANI-carbon nanotube composites and it retains the full capacitance under large bending angles. The capacitor exhibits high energy and power densities (5.8 Wh/kg at 1.1 kW/kg), a superior rate capability (still 81% of the 1 A/g capacitance at 10 A/g) and long-term electrochemical stability (83.2% retention after 2000 cycles).