bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opioids and Cannabinoids in Neurology Practice
Authors: Sandbrink Friedhelm , Schuster Nathaniel M. 
Published: October 2024

ABSTRACT

OBJECTIVE
Opioid and cannabinoid therapies for chronic pain conditions including neuropathic pain are controversial. Understanding patient and prescribing factors contributing to risks and implementing risk mitigation strategies optimizes outcomes.

LATEST DEVELOPMENTS
The ongoing transformation from a biomedical model of pain care toward a biopsychosocial model has been accompanied by a shift away from opioid therapy for pain, in particular for chronic pain. Opioid overdose deaths and opioid use disorder have greatly increased in the last several decades, initially because of increases in opioid prescribing and more recently associated with illicit drug use, in particular fentanyl derivatives. Opioid risk mitigation strategies may reduce risks related to opioid prescribing and tapering or discontinuation. Opioid therapy guidelines from the Centers for Disease Control and Prevention have become the consensus best practice for opioid therapy. Regulatory agencies and licensing medical boards have implemented restrictions and other mandates regarding opioid therapy. Meanwhile, interest in and use of cannabinoids for chronic pain has grown in the United States.

ESSENTIAL POINTS
Opioid therapy is generally not recommended for the chronic treatment of neuropathic pain conditions. Opioids may be considered for temporary use in patients with severe pain related to selected neuropathic pain conditions (such as postherpetic neuralgia), and only as part of a multimodal treatment regimen. Opioid risk mitigation strategies include careful patient selection and evaluation, patient education and informed consent, querying the state prescription drug monitoring programs, urine drug testing, and issuance of naloxone as potential rescue medication. Close follow-up when initiating or adjusting opioid therapy and frequent reevaluation during long-term opioid therapy is required. There is evidence for the efficacy of cannabinoids for neuropathic pain, with meaningful response rates in select patient populations.
Infliximab in the treatment of a giant coronary aneurysm in Behçet’s disease
Authors: Boustani Salma , Ibnyghig Abderrahmane , Wakrim Soukaing , Bouissgr Wassila 
Published: October 2024

Background: Behçet’s disease (BD) is a rare, multisystemic inflammatory disorder with a diverse range of manifestations, primarily affecting the mucocutaneous and ocular systems. While vascular involvement is less frequent it can be severe, with coronary aneurysms being particularly rare. Case description: We report a 28-year-old male with BD who developed a giant anterior interventricular artery aneurysm. The patient, initially managed with azathioprine and colchicine, presented with acute chest pain and elevated cardiac markers. Imaging revealed a coronary aneurysm measuring 5.03 cm. Due to the inflammatory nature of the aneurysm surgical intervention was initially deferred, and the patient was treated with corticosteroids and cyclophosphamide. Despite these treatments, recurrent symptoms prompted the initiation of infliximab therapy. Administered at 5 mg/kg at weeks 0, 2 and 6, with subsequent doses every two months, infliximab led to a significant reduction in aneurysm size to 3.73 cm. Conclusion: This case highlights the effectiveness of infliximab in managing giant coronary aneurysms associated with BD, demonstrating its potential as a treatment option for severe vascular complications in BD. The substantial reduction in aneurysm size following infliximab therapy underscores the need for further investigation into its role in treating such rare but serious manifestations of BD.
Toward Requirements for Embedded Systems
Authors: Ribeiro Quelita , Pereira Tarcísio , Melo Mozart , Castro Jaelson , Alencar Fernanda , Lencastre Maria 
Published: October 2024

Context: Embedded System (ES) is a component of a larger system embedded in a product, it is designed to repeatedly perform a specific function, while maintaining its operation under different constraints. For this reason, these systems are highly complex. Therefore, the challenges for effective and efficient development are immense. Many problems are related to mistakes in the requirements engineering phase. Thus, a Requirements Engineering (RE) process is crucial in ES development. Objective: to analyze and understand studies of RE approaches that are used for embedded systems development. Method: We carried out a Systematic Literature Review (SLR) in order to find answers to our questions and better understand the requirements engineering context for ES. Results: We uncovered 92 studies and (1) evidence the benefits to using the studies in requirements engineering activities; (2) we found out the RE phases that are attracting more attention; (3) the main requirements modeling styles used; (4) the types of requirements modelled; (5) we identified 6 embedded systems domain in which requirements engineering is taken into account; (6) the use of tools to support their approaches, and (7) the existing challenges/problems. We also proposed a research agenda. Conclusions: Hence, in this paper we present a body of knowledge in ER for SE derived from a large-scale SLR. We believe the results will benefit both researchers and practitioners.
Large variability in degree of constraint of reverse total shoulder arthroplasty liners between different implant systems
Authors: Moroder Philipp , Herbst Eva , Pawelke Jonas , Lappen Sebastian , Schulz Eva 
Published: October 2024

AimsThe liner design is a key determinant of the constraint of a reverse total shoulder arthroplasty (rTSA). The aim of this study was to compare the degree of constraint of rTSA liners between different implant systems.MethodsAn implant company’s independent 3D shoulder arthroplasty planning software (mediCAD 3D shoulder v. 7.0, module v. 2.1.84.173.43) was used to determine the jump height of standard and constrained liners of different sizes (radius of curvature) of all available companies. The obtained parameters were used to calculate the stability ratio (degree of constraint) and angle of coverage (degree of glenosphere coverage by liner) of the different systems. Measurements were independently performed by two raters, and intraclass correlation coefficients were calculated to perform a reliability analysis. Additionally, measurements were compared with parameters provided by the companies themselves, when available, to ensure validity of the software-derived measurements.ResultsThere were variations in jump height between rTSA systems at a given size, resulting in large differences in stability ratio between systems. Standard liners exhibited a stability ratio range from 126% to 214% (mean 158% (SD 23%)) and constrained liners a range from 151% to 479% (mean 245% (SD 76%)). The angle of coverage showed a range from 103° to 130° (mean 115° (SD 7°)) for standard and a range from 113° to 156° (mean 133° (SD 11°)) for constrained liners. Four arthroplasty systems kept the stability ratio of standard liners constant (within 5%) across different sizes, while one system showed slight inconsistencies (within 10%), and ten arthroplasty systems showed large inconsistencies (range 11% to 28%). The stability ratio of constrained liners was consistent across different sizes in two arthroplasty systems and inconsistent in seven systems (range 18% to 106%).ConclusionLarge differences in jump height and resulting degree of constraint of rTSA liners were observed between different implant systems, and in many cases even within the same implant systems. While the immediate clinical effect remains unclear, in theory the degree of constraint of the liner plays an important role for the dislocation and notching risk of a rTSA system.Cite this article: Bone Jt Open 2024;5(10):818–824.
Fighting Alone or Mutual Benefit and Win? A Study on Forestry Embodied Energy Competition Network Based on MRIO
Authors: Ni Jing-Sheng , Dong Juan , Zheng Ming-Gui 
Published: October 2024

Abstract
Measuring energy usage in the forestry trade is a topic of great significance. In this article, we use the World Input–Output Database and the multiregional input–output model to establish an embodied energy competition network and assess the influence of global value chain (GVC) integration on competition. The results show that (1) the intensity of competition for embodied energy in forestry is higher for exports compared with imports. Additionally, the import competition network exhibits lower connectivity and overall efficiency. (2) The core regions of the competitive network are primarily found in Europe, Asia, and the Americas. The United States consistently maintains a competitive advantage. However, forestry policies have led to a decline in the status of the United States, (3) The hierarchical structure of export competition is more pronounced. When the weighting degree exceeds 200, this phenomenon becomes more pronounced. (4) From the perspective of GVC, positive embedding in the GVC is negatively correlated with import competition. Backward GVC embedding is positively correlated with import and export competition. On the basis of the above results, this article proposes that countries where backward embedding is the main method should actively participate in building appropriate export international associations, participating in international organizations, and building a relatively harmonious and stable export competition market, thereby helping to maintain economic development and energy environment management.
Challenges in Building a Secure Sustainable Society Amid Global Risks and Threats: Theoretical and Practical Aspects
Authors: Vilks Andrejs , Kipane Aldona , Kuzņecova Kristine 
Published: October 2024

The development of society must be based on its sustainability. The current geopolitical situation is linked to extensive security challenges, new extremist manifestations, and threats at international and national levels. In today’s circumstances, the classic conventional threats are complemented by new global threats: hybrid threats, terrorism, cybercrime, and transnational organised crime. The multiple factors affecting public security and its sustainable development are changing. The new types of threats destabilise international policies in the implementation of the strategy for the sustainable development of society, which requires an objectively determined need for their interdisciplinary study. The study process should take into account that the geopolitical situation is highly dynamic, and the perception and evaluation of its transformation are variable. The study results show that people face feelings of insecurity, anxiety, and depression in current socio-political settings. International global security index scores generally show adverse patterns in these parameters for countries and cities. The study uses a variety of information sources and cognitive tools to identify the state of security and its threats. Its results will contribute to the development of practical conceptual frameworks for the further development of a sustainable and safe society, taking into account global risks and threats. In a turbulent era characterised by risks, one needs to learn how to understand, anticipate, assess, manage, and mitigate their potential negative impacts. This requires appropriate action, technological solutions, and changes in attitudes.

Keywords: Security, society, sustainable development, threats
Sustainability in Enterprise Architecture: From Optional to Essential
Authors: Alghamdi Hassan 
Published: October 2024

This study investigates the integration of sustainability into Enterprise Architecture (EA) and its impact on organizational performance. It examines how sustainable EA practices influence efficiency, compliance with environmental regulations, stakeholder engagement, and innovation within organizations. The research employs a structured Likert scale questionnaire targeting professionals in various industries. Findings reveal a positive correlation between sustainable EA practices and improved organizational performance, regulatory compliance, and innovation. However, challenges such as high costs and organizational resistance persist, particularly for Small and Medium-sized Enterprises (SMEs). The study highlights the importance of leadership support and technological readiness in overcoming these barriers. This research contributes to understanding the strategic role of sustainability in EA, offering insights for enhancing organizational resilience and competitiveness.
Keywords: Enterprise Architecture (EA); Sustainability; Sustainable EA practices; Small and Medium-sized Enterprises (SMEs)
An Exploratory Study on E-Waste Reporting: A Review of Annual Reports from Malaysian Public Listed Companies
Authors: Azman Nik Amalena Najebah Nik , Salleh Sharina Mohd , Hanafi Wan Noordiana Wan , Ya’acob Nur Shuhada , Alrazi  Bakhtiar , Yusoff Haslinda 
Published: October 2024

Electronic waste (e-waste) has emerged as a critical global issue due to the environmental and health impacts. Moreover, a significant portion remains unrecorded and improperly managed. Hence, effective e-waste management is crucial to mitigating associated risks and ensuring environmental sustainability. The current study examined e-waste reporting practices among Malaysian Public Listed Companies (PLCs), assessed PLC commitments to environmental sustainability, and explored the legitimacy theory in understanding e-waste reporting.
This study focused on Malaysian PLCs. The sample comprises 114 PLCs distributed across various sectors, such as construction, consumer products and services, energy, financial services, healthcare, and technology, which represented 15% of the total population. A content analysis approach was employed to identify relevant information in annual reports. Subsequently, a categorisation scheme with eight content categories across four dimensions was adapted from previous research to analyse e-waste reporting practices.
The findings revealed that the e-waste reporting among PLCs was low as the information was primarily declarative and neutral. Varying commitment levels were also observed across different sectors, which highlighted the communication methods of PLCs on e-waste management practices. The legitimacy theory was applied to appraise the factors contributing to e-waste reporting behaviours.
The findings contributed to a deeper understanding of how different industries managed e-waste and valuable insights into the most optimal practices to be adopted across sectors. The study results also underscored the need for standardised reporting frameworks to enhance transparency and corporate responsibility towards environmental sustainability.
Keywords: E-waste Reporting, Malaysian Public Listed Companies, Legitimacy Theory, Environmental Sustainability, Content Analysis
The Impact of State Funding of Higher Education on Employment and Living Standards in Georgia
Authors: Shainidze Ekaterine , , Mamuladze Nino , Katamadze3 Giorgi , Ghoghoberidze Tamar 
Published: October 2024

State financing of higher education is crucial for promoting innovation and competition, as well as guaranteeing equal opportunities and access to education. This financing facilitates the development of students' potential by providing them with the necessary skills and information to enhance graduation rates and social well-being. Scholarships and grants are implemented to improve student access to education by aligning the financial system with the demands of the job market and educational developments.
The aim of the study is to evaluate the impact of financing higher education in Georgia on employment of graduates and well-being of the population.
The results of the survey of entrants and students reveal that public awareness of state-funded higher education programs in Georgia is quite low (47.2%). A large part of the graduates (47,8%) provided with various types of state funding during their studies are not employed in their specialty. The impact of the increase in the expenditure on education on the increase in the income of the population is quite low (0.23%).
The research concludes that the allocation of public funds for higher education in Georgia does not effectively match the capabilities of graduates with the demands of the labour market. The reason for the mentioned inconsistency is that the requirements of the labor market were not taken into account when determining the directions to be financed. In addition, it is important to note that the demands of the labor market change every year in accordance with the current challenges, therefore the employer also demands relevant skills immediately, which cannot be met by higher education institutions in a short period of time. Despite the above, the involvement of employers in the process of developing educational programs is low and it is mostly formal in nature. When determining the priority educational programs, there is no periodic revision of the directions so that it is adapted to the demands of the labor market. It is necessary to establish partnership relations between employers, higher educational institutions and the state in order to take into account the requirements of the labor market both in the development of educational programs and in the determination of priority educational directions. Enhancing transparency and emphasising practical training in key areas are essential for enhancing the program's efficacy and enhancing the career chances of graduates. These modifications will provide a more favourable return on investment for state education expenditure.
Keywords: higher education, state financing, employment, living standards
Challenges and Perspectives of the Startup Ecosystem for the Development of Innovative Economy in Georgia
Authors: Abuselidze George , Tsiklashvili Natela , Verulidze Vazha , Glonti Vladimer , Gechbaia Badri , Robitashvili Natalia 
Published: October 2024

The processes of introduction of technology and innovation ecosystem in the economic development of the country have attracted special attention in the global world in the conditions of pandemic and post-pandemic. Accordingly, the research focuses on the formation and development models of modern start-up ecosystems, processes and determinants that ensure their transformation into innovations and the transfer of resources for economic development in the regions. The aim of the paper is to determine the main directions that will contribute to the development of startup ecosystems, taking into account global trends and state-specific practices; The research is based on the methods of grouping, comparison, analogy, analysis, generalization and systemic-structural approaches. As a result of the research, startup ecosystems were defined as an institutional mechanism that is open to the expansion of intersectoral networks and changes the competitive market environment in favor of the architecture of a stable innovative economy. The examples of Estonia, Spain, and Britain show the potential of developing a national startup ecosystem model that prioritizes long-term development, state technical self-sufficiency, and the ability to expand to new markets.

Keywords: innovative economy, ecosystems, technoparks, startups, innovations, R&D, economic development
Shifting Boundaries of Marketing Management in E-Commerce: A Study through TAM (Technology Acceptance Model)
Authors: Manna Yahya 
Published: October 2024

This research tries to investigate the adoption of information technology and its constituents by the customers while making decisions to buy any product from the market utilising TAM. Many political and business related changes are being made in the context of marketing management. In the past 20 years, every domain of management has seen a transformation. Text explosion and information, information, technology and advancement in transport and communication revolutionised every domain of management marketing management which was regarded as the cost for the management is now regarded and recognised at the strategic level. The marketing managers are now enjoying high status in the corporate world. Traditionally, the field of marketing management was dependent on mass media and broadcast media, but with the advent of social media and the access of Internet to almost more than 50% of the consumers in every industry has transformed the field of marketing management.
This change was recognised by many authors and researchers around the globe and there is a need to research from customers perspective that how easily consumers are adopting technology in decision making, For the assessment Technology Acceptance Model (TAM) was utilised. The data was collected from (n=138) marketing managers, the data was analysed by the use of SPSS 22.0 for descriptive analysis and for regression analysis and structural modelling method was applied. The finding suggest the technology acceptance model is highly applicable to marketing activities and some of its constituents rank high when it comes to make a decision to buy any product by the customer. However Attitude of using does not have any direct impact on Intention to use.
Keywords: Marketing Managers, Status of Marketing managers, SEM, Lisrel 9.0., information technology, marketing activities.
Cultivating Innovative Work Behavior: Insights from HRM Practices Integration
Authors: Manalo Hernani D. , Manalo Ma. Riza T. , Bibangco El Jireh P. 
Published: October 2024

Innovative Work Behavior (IWB) has a prominent space in various literature, but what cultivates it remains inconsistent and fragmented. This study posits that controlled Human Resource (HR) practices can foster Innovative Work Behavior (IWB). It used Reflective Thematic Analysis (RTA) to examine from the lens of Perceived Organizational Support (POS) and Learning Culture (LC) theories based on the insights of 10 expert-respondents across 8 industries. The findings revealed that the organization’s support and the synergy of HR practices such as Diversity Management (DM), Work Life Balance (WLB), and Training and Development (TD) significantly succeeded to cultivate IWB while Rewards and Recognition (RR) practices failed to cultivate the desired behavior. The study also showed that championing cultural diversity and observing employees’ balanced work-family time propelled innovative behavior. Likewise, Learning Culture (LC) as enhanced by TD, DM, and WLB practices escalated the employees’ IWB. The study recommends to strategize RR practices, focusing on intrinsic rewards that are linked to IWB and to enhance TD practices for sustainable learning. It further highlights the crucial role of organizational support through HRM practices and learning culture in cultivating IWB. Since IWB is multi-factored, an investigation on other factors not addressed in this study and longitudinal research must be conducted to ensure consistent findings. The future direction of this study should also focus on external factors such as technological advancement, market competition, and regulatory environment that shall redefine the organization’s core values and consequently frame employees’ Innovative Work Behavior. This study does not only contribute to the existing body of literature, but also offers significant insights for both HR and Innovation managers in their respective practices.
Keywords: Innovative Work Behavior, HR Practices, Organizational Performance, Diversity Management, Work-Life Balance, Training and Development, Rewards and Recognition, Perceived Organizational Support (POS) Theory, Learning Culture (LC) Theory