bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Adapted Characteristic in the Range of Motion of the Shoulder for Young Male Volleyball Players
Authors: Chou Kun-Yu , Wu Wan-Ling , Chiu Chun-Wen , Cheng Shih-Chung , Chang Hsiao-Yun 
Published: October 2024

Abstract

Background
Volleyball players often repeatedly perform spiking and serving, which may lead to muscle microtrauma of the shoulder and consequently reduce shoulder joint range of motion (ROM) and increase the risk of shoulder injuries.
Aims
This study aimed to understand and evaluate the bilateral shoulder ROM in high school male volleyball athletes to discover the adapted characteristics.
Methods
Forty high school male volleyball athletes participated in this study. The shoulder ROM measurements were taken for both the dominant and non-dominant sides. The paired samples t-tests were used to analyze shoulder ROM differences between the dominant and non-dominant sides.
Results
The dominant side showed a significantly lower in internal rotation (p = .000) and total shoulder rotation ROM (p = .021) compared to the non-dominant side (p < .05). Conversely, the dominant side of the shoulder exhibited significantly greater external rotation (p = .001) and shoulder horizontal adduction (p = .000) than the non-dominant side (p < .05). No significant differences were found in other measured parameters. The incidence of Glenohumeral Internal Rotation Deficit (GIRD) among all subjects was 37.5%.
Conclusions
High school male volleyball athletes in this study exhibited tightness in the posterior shoulder of their dominant side, indicating specific adaptations in shoulder ROM and a considerable prevalence of GIRD, observed in approximately one-quarter of the athletes. It is recommended to incorporate stretching and eccentric muscle training focusing on the posterior shoulder to mitigate these adaptations and reduce the risk of shoulder injuries.
Alarming nutritional profile of a collegiate men’s field hockey team of University of Delhi: Reasons why a sports team may fail in competition
Authors: Bajaj Vrishabh , Tyagi Prof. (Dr.) Sarita , Wasuja Prof. (Dr.) Monika , Vanaik Prof. (Dr.) Anil 
Published: October 2024

Abstract

Purpose
Performance in Field hockey (FH) can be optimized with Sports Nutrition. Unfortunately, available studies have reported nutritional deficiencies in the players which may significantly affect their competitive performance and ultimately sports career. The study recruited a collegiate men's FH team (n=16) of University of Delhi (DU) to assess their total daily energy expenditure (TDEE) and nutritional profile of macronutrients and water intake during the University’s FH championship 2017-18.
Methods
Data was collected through 3 days activity and dietary recall forms, and assessments were done using factorial estimation method and DietCal software. For analyses, Shapiro-Wilk test was applied to all variables for normality testing and finally, the measures of mean, median, standard deviation, and percentage for descriptive analyses; and student’s t-test, Wilcoxon signed-rank test, along with Cohen’s dand Pearson’s r effect size tests for inferential analyses were applied to compare the players’ profile with their competitive requirements.
Results
Student’s t-test indicated a significant state of negative energy balance (p-value = 0.00005; α = <0.05; d = 0.8). Furthermore, Wilcoxon signed-rank tests revealed significant deficiencies of carbohydrate (p-value = 0.00001; α = <0.05; r = -1.04); protein (p-value = 0.00001; α = <0.05; r = -1.04); water upon awakening on match days (p-value = 0.00009; α = <0.05; r = -0.93); water 20-30 minutes before matches (p-value = 0.001; α = <0.05; r = -0.83); and water during matches (p-value = 0.0006; α = <0.05; r = -0.79). Only the fat intake was found to be marginally sufficient (p-value = 0.05; α = <0.05; r = -0.40).
Conclusion
The reported nutritional deficiencies might have contributed to the team’s poor performance and failure in the championship. Regular and personalized dietary assistance to the players is warranted to ensure their peak performance, top results in the future championships, and a successful sports career.
Cryopreservation of Fegra Fig (Ficus palmata Forssk.) and Genetic Fidelity of the Recovered Micropropagated Plants
Authors: Al-Aizari Ahmed Ali , Dewir Yaser Hassan , Al-Obeed Rashid Sultan , Ghazy Abelhalim , Almutairi Khalid F. , Al-Doss Abdullah 
Published: October 2024

Cryopreservation allows for the long-term storage of biological materials, ensuring their viability for future use and preserving biodiversity. This study aimed to develop an efficient protocol for the long-term in vitro conservation of fegra fig. In vitro precultured shoot tips of fegra fig with 0.3 M sucrose showed the highest regrowth percentage (100%) before plunging into liquid nitrogen. After plunging into liquid nitrogen, the regrowth percentage was 43.33%. Following cryopreservation, the recovered shoots were rooted and acclimatized to ex vitro conditions. The genetic fidelity of the acclimatized 8-week-old fegra fig plantlets after cryopreservation with their mother plant was tested using randomly amplified polymorphic DNA (RAPD), inter simple sequence repeats (ISSR), and start codon targeted (SCoT) molecular markers. Genetic similarity between the stored plantlets with their mother plant was 100% ensuring uniformity and true-to-type regenerated plants following cryopreservation. This study presents, for the first time, an efficient protocol for the genetic conservation of fegra fig.
Impact of Obesity, Menopause, and Depression in Women’s Health: An Attempt to Decipher the Complex Relationship
Authors: Barbhuiya Pervej Alom , Pathak Manash Pratim 
Published: October 2024

Background:
Menopause symptoms may be distressing, especially when
they appear at a time when women are expected to play significant responsibilities in society.
Numerous biological systems are influenced by the hormonal changes that start
during the menopausal transition. This review attempts to decipher the complex relationship
between obesity, menopause, and depression, citing some recent longitudinal and
cross-sectional studies. Additionally, this study provides a summary of the different phytoestrogens,
their sources, and probable mechanisms of action in addition to available
therapeutic alternatives.

Methodology:
For this review purpose, the authors have gone through a vast number of
articles from various scientific databases like PubMed, Google Scholar, and Web of Science.

Results:
It is becoming clear that the physiological basis for these menopausal symptoms
is complicated and connected to estrogen deficiency, but not alone. Other hormones
like FSH, LH, progesterone, and inhibin B are the major ones that are both directly
and indirectly responsible for most of the menopausal symptoms. Numerous longitudinal
and cross-sectional studies have found a direct relationship between the incidence of
menopause and depression as well as obesity. Phytoestrogens like stilbene, lignans,
isoflavone, and coumestan have been reported to be the alternatives to synthetic estrogen
with lesser side effects, as reported in various studies.

Conclusion:
The complex relationship between depression, menopause, and obesity presents
a complex obstacle to women's health and overall well-being. There might be a lot
of promising prospects for revolutionary advancements in women's health during the
menopausal stage in the future. Promising drug development that targets not just one but
also the three conditions -obesity, menopause, and depression - as well as more thorough
research are needed to improve the healthcare system for women who suffer from
these conditions.
Parthenolide Inhibits Tumor Cell Growth and Metastasis in Melanoma A2058 Cells
Authors: Dorostgou Zahra , Hoseyni Malihe , Bahrami Afsaneh , Zhiani Rahele , Mohtashami Mahnaz 
Published: October 2024

Background:
Skin melanoma is a potentially lethal cancer and ranks as the
17th most common cancer worldwide. Overcoming resistance to advanced-stage melanoma
is a significant challenge in its treatment. Parthenolide (PAR) is recognized as a potent
anticancer small molecule, yet its potential in treating melanoma is poorly investigated.

Objective:
Our objective was to investigate the apoptotic and anti-metastatic properties
of PAR against the A2058 melanoma cells in vitro.

Methods:
This study employed various assays, such as cytotoxicity, apoptosis, cell cycle
analysis, reactive oxygen species (ROS) production, mRNA expressions, western
blotting, gelatin zymography, and scratch assay. The synergy between PAR and dacarbazine,
a chemotherapy drug for treating skin cancer, was also assessed.

Results:
Our study revealed that PAR significantly reduced the viability of A2058 cancer
cells, demonstrating greater potency against cancer cells compared to normal L929
cells (IC50: 20 μM vs. 27 μM after 24h). PAR increased ROS production, elevated mRNA
expression of pro-apoptotic Bax and NME1 genes, and decreased expression of the
MITF gene. PAR induced apoptosis and cell cycle arrest in A2058 cells, as evidenced
by the increased proportion of cells in the late apoptotic phase and sub-G1 cell cycle arrest.
MMP-2 and MMP-9 mRNA and protein expressions, gelatinase activity, and the migration
of A2058 cells were also decreased by PAR, suggesting its potential to suppress
cancer cell invasion.

Conclusion:
These results, along with the synergic effect with dacarbazine, indicated
that PAR may have the potential to be a therapeutic drug for melanoma by triggering
apoptosis and suppressing invasion and migration.
A Novel Drug Delivery Platform Against Bacterial Resistance: Synthesis
and Characterization of Ciprofloxacin-loaded MCM-41 Mesoporous Silica
Nanoparticle
Authors: Sam Sanaz , Bagheri Amir Mohammad , Yahyapour Moghadeseh , Ranjbar Mehdi , Moshafi Mohammad Hassan 
Published: October 2024

Backgrounds:
Advances in nanotechnology have revealed innovative applications in
pharmaceutical sciences to solve unmet medical needs. Over the past decades, antibiotic resistance
has emerged as a global concern. This catastrophic phenomenon, with a rapid increase in frequency,
indicates the urgent need for the introduction of new approaches. In this respect, as a class of inorganic
nanomaterials, mesoporous silica nanoparticles (MSNs) are of interest. Amongst, MCM-41
(MCM-Mobil Composition of Matter) possesses many advantages suitable for biomedical applications
such as high pore volume, large surface area capacity, and controlled release properties as well
as high bioavailability.

Objectives:
In the current study, we aimed to develop a new drug delivery platform of ciprofloxacin
(CIP) to combat antibiotic resistance practically using MSNs.

Methods:
The MCM-41 nanoparticles were synthesized using surfactant as the templating agent.
Afterward, drug molecules were loaded in the prepared mesoporous structure, and several experiments
were conducted to assess physicochemical properties. As well, the encapsulation efficiency,
release profile, and antibacterial properties were also evaluated.

Results:
The CIP-loaded MCM-41 (CIP@MCM-41) nanoparticles represented good physicochemical
properties. The results of the DLS method showed a particle size of 93.73 nm with a low polydispersity
index (PDI) of 0.21, while SEM imaging demonstrated spherical particles with relative shape
uniformity and size distribution. The encapsulation efficacy of MCM-41 MSNs for CIP was measured
to be 28.7 % ± 0.37 followed by negligible changes over 60 days. The release profile of CIP
from prepared nanoparticles was also demonstrated to follow the zero-order kinetic model. Moreover,
CIP@MCM-41 nanoparticles exhibited high antibacterial properties against test microorganisms
(Escherichia coli, Klebsiella pneumoniae, Staphylococcus epidermidis, and Micrococcus luteus).

Conclusion:
The current formulation could be a promising candidate for the delivery of therapeutic
agents to combat antibiotic resistance and promote public health.
Direct Oral Anticoagulants and Cancer-related Venous Thromboembolism: Insights from an Updated Meta-Analysis
Authors: Omidi Fatemeh , Sadeghi Soheila , Rahmannia Maryam , Bonjar Amir Hashem Shahidi , Berger Nathan A. , Nasiri Mohammad Javad 
Published: October 2024

Introduction:
Cancer-associated venous thromboembolism (VTE) presents a complex
clinical challenge, with the need to balance effective anticoagulation against the risk of bleeding.
Direct oral anticoagulants (DOACs) offer convenience but their efficacy and safety in this context
remain debated. This systematic review and meta-analysis endeavor to evaluate the effectiveness
and safety of DOACs in managing VTE associated with cancer. The findings offer essential perspectives
to guide clinical decision-making.

Methods:
We performed an exhaustive search across electronic databases such, as PubMed, EMBASE,
and the Cochrane CENTRAL, spanning from their inception to December 15, 2023. Only
English-published articles evaluating the effectiveness and safety of DOACs in managing cancer-
associated VTE were considered. Evaluation criteria encompassed recurrent VTE, major bleeding
(MB), clinically significant non-major bleeding (CSNMB), and clinically relevant bleeding
(CRB). Statistical analyses were conducted utilizing Comprehensive Meta-Analysis software.

Results:
From the 1195 records, 8 studies with 3913 patients were included. DOACs demonstrated
a significant reduction in recurrent VTE risk (OR: 0.73, CI 95%: 0.57-0.93, p =0.01) compared
to traditional anticoagulants. However, there was a marginal increase in MB risk (OR: 1.24, CI
95%: 0.90-1.69, p =0.17) with DOACs, though not statistically significant. Notably, DOACs were
associated with a higher risk of CRNMB (OR: 1.64, CI 95%: 1.24-2.17, p <0.001) and CRB (OR:
1.22, CI 95%: 1.00-1.52, p =0.04). No publication bias was observed. Gastrointestinal cancer, Rivaroxaban/
apixaban use, switching from dalteparin, improved physical function with DOACs, specific
tumor sites, and older age subgroups were predictors for bleeding complications in cancer patients
on anticoagulant therapy.

Conclusion:
This meta-analysis provides evidence supporting the efficacy of DOACs in reducing
VTE recurrence in cancer patients. However, the increased risk of bleeding complications warrants
careful consideration in personalized treatment decisions. Ongoing research is necessary to
refine therapeutic strategies in this complex clinical landscape.
A Brief Review on Caenorhabditis elegans Role in Modelling Neurodegenerative Disease
Authors: Vig Himangi , shukla Priyanka , Mishra Anamika , pal Ayushi , Wal Ankita 
Published: October 2024

Abstract:
A small, translucent nematode known as Caenorhabditis elegans, or C. elegans, is
frequently utilized as a model organism in biomedical studies. These worms, which are around
1 mm long and feed on bacteria, are usually found in soil. For accessible and effective research
on genetics, developmental biology, neuroscience, cell biology, and aging, C. elegans provide
an ideal model. Its simplicity, which includes a translucent body and a nervous system with only
302 neurons, makes it possible to see cellular and developmental processes in great detail. Because
of its special benefits, the worm Caenorhabditis elegans allows for a thorough characterization
of the cellular and molecular processes causing age-related neurodegenerative diseases.
This is a general review of the life cycle, experimental methodologies, and the use of C. elegans
to model brain diseases, including those related to molecular and genetic factors that cause neurodegenerative
diseases. Additionally, we go over how C. elegans is a perfect model organism
for studying neurons in instances of prevalent age-related neurodegenerative illnesses due to a
combination of its biological traits and new analytical techniques.
The literature review process was carried out step-by-step using online search databases such as
Web of Science, PubMED, Embase, Google Scholar, Medline, and Google Patents. In the first
searches, keywords like C.elegans, disease modelling, and neuroprotective activity were employed.
Because of C. elegans's physiological transparency, it is possible to track the development of
neurodegeneration in aging organisms by using co-expressed fluorescent proteins. Importantly,
a fully characterized connectome provides a unique ability to precisely connect cellular death
with behavioural instability or phenotypic diversity in vivo, thus permitting a deep knowledge
of the detrimental effect of neurodegeneration on wellbeing.
In addition, pharmacological therapies and both forward and reverse gene screening speed up
the discovery of modifiers that change neurodegeneration. These chemical-genetic investigations
work together to determine important threshold states that either increase or decrease cellular
stress in order to unravel related pathways.
A Bibliometric Analysis of Research Trends in Aging and Leisure Activities from 2000 to 2023
Authors: Begam J Mufina , Azeez E P. Abdul 
Published: October 2024

Background:
Physical and leisure activities are vital for active aging. Leisure activities
among the aging population have received attention from scholars in the recent past. However,
the research contributions and trends in this field are unknown. Therefore, a bibliometric
analysis was conducted to explore the scholarly contributions in aging and leisure activities to
identify the research output trends, assess thematic focuses, and analyze research collaboration
patterns.

Methods:
We extracted data from the Scopus database for the period 2000-2023 and identified
443 articles focusing on aging and leisure activities. Tools, such as bibliographical coupling
networks and thematic analysis, were applied using R and Biblioshiny to uncover core themes
and connections.

Results:
There has been a significant increase in research output since 2021, with contributions
from numerous authors and countries, particularly the United States and China. Thematic analysis
reveals central themes, such as physical activity, successful aging, and cognition.

Conclusion:
This analysis reveals the evolving nature of scholarly discussions in aging and leisure,
highlighting key themes, such as physical activity, cognitive aging, and health promotion.
The findings emphasize the growing interest and global collaboration in this interdisciplinary
research domain.
Intestinal Anti-Inflammatory and Antioxidant Potential of Arthrospira platensis Aqueous Extract on DNBS-Induced Colitis in BALB/c Mice
Authors: Aziez Meriem , Bribi Noureddine , Merakeb Mohamed Sofiane , Ferhat Riad , Affenai Safia 
Published: October 2024

Background:
The most common Inflammatory Bowel Diseases (IBD) affecting the gastrointestinal
system are Crohn's disease and ulcerative colitis. However, the usual therapies for them
are associated with a multitude of side effects. The blue-green microalgae Arthrospira platensis is
known for its safety profile, nutritional, and medicinal properties in the treatment of different inflammatory
and gastrointestinal disorders.

Objective:
The objective of this study was to investigate the potential intestinal anti-inflammatory
effects of the aqueous extract derived from Arthrospira platensis (AAP) in a mouse model of
DNBS-induced colitis.

Methods:
GC-MS and FTIR-ATR were used to determine the different types of chemical compounds
found in the AAP extract. BALB/c mice that received DNBS intrarectally were treated with
three doses (50, 100 and 200 mg/kg) of AAP for three days. The inflammatory status was assessed
daily using a Disease Activity Index (DAI). Mice were sacrificed on the third day, and the extent of
colonic damage was evaluated through both macroscopic and histological examinations. Finally,
biochemical assays of different markers (MDA, NO, and GSH) were performed.

Results:
The GC-MS analysis revealed the presence of eleven bioactive compounds, including 2-
thiophenecarboxylic acid, 2-biphenyl ester, palmitic acid, 2-linoleoyl glycerol, ethyl isoallocholate,
and methyl palmitate. In addition, FTIR spectroscopy revealed the presence of amino, hydroxyl,
and glucosidic groups. The treatment of colitic mice with AAP decreased the severity of colitis, as
demonstrated by the improvement in the clinical score and the reduction of colonic tissue damage,
as well as the modulation of the local biochemical marker levels.

Conclusion:
The AAP effectively improves DNBS-induced colitis, but its short treatment duration
and focus on acute colitis highlight the need for further research on long-term and chronic effects.
Organizational foundations of the post-war restoration of the railway healthcare system in the territories of the Central Chernozem regions (1945‒1959)
Authors: Golovin E. A. 
Published: October 2024

The relevance. The geopolitical situation that has developed at the moment, of course, emphasizes the extremely important importance of providing timely and qualified medical care, primarily in critical and non-standard conditions. In 2024, the healthcare system on the country's railways turns 180 years old. During this time, Russian transport medicine has accumulated a wealth of experience in maintaining the health of railway workers and their family members, even in the most difficult periods of history. In the post-war years, there was an active restoration of the functioning of medical and sanitary institutions on railway transport. By 1950, large-scale work was carried out in the Central Chernozem region to expand the medical network and the volume of services for railway workers, their family members, as well as industry veterans. It should be noted that the railway healthcare system has performed and continues to perform important social functions, guaranteeing medical care to employees with a special regime of performing professional duties. That is why the study of the experience of the functioning of transport medicine is relevant today.The purpose of the study is to comprehensively consider the organizational, managerial, and logistical conditions for the development of transport healthcare in the Central Chernozem region in the 1940s and early 1950s.The objectives: to reveal the specifics of healthcare in railway transport in the period under review; to characterize the main problems in the organization of medical care for railway workers.Methodology. The principles of objectivity and historicism were used as the methodological basis of the work. To solve the tasks set, the author used historical-genetic, historical-systemic, historical-comparative, typological, retrospective methods.Results. The study and generalization of archival sources made it possible to objectively assess the specifics and problems of medical care for railway workers in the regions of the Central Chernozem region in the first post-war years.Conclusions. During the period under review, transport healthcare in the Central Chernozem region was actively restored and developed. The full-fledged provision of qualified medical care to railway workers was primarily hampered by logistical problems.