bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum metabolic profile evidence for relationship between schizophrenia and depression: An untargeted metabolomics
Authors: Zhang Jing , Ren Ruru , Ding Shuqin , Sa Yuping , Zhang Weiman , Wang Weibiao , Wilson Gidion , Ma Xueqin , Gong Kaimin 
Published: October 2024

AbstractGiven the genetic and clinical overlap observed between schizophrenia and depression, the present study was to identify the similarities and differences in serum metabolic profiles between patients with schizophrenia and depression. Global metabolomics research methods based on UHPLC‐QTOF‐MS/MS were performed. A total of 113 and 118 differential metabolites were screened and identified in depression and schizophrenia groups, respectively, as compared to health control; among those, 94 differential metabolites were shared by both. Pathway analysis indicated arginine and proline metabolism, alanine, aspartate, and glutamate metabolism were two significant metabolic pathways both in depression and schizophrenia groups as compared with health control groups, respectively. Similarly, 77 differential metabolites were identified between depression and schizophrenia groups, in which, serum N‐acetylglutamine and isovalerylglycine levels showed significant differences between patients with depression and schizophrenia with p values less than 0.001 and without significant outliers. Sphingolipid metabolism was identified as a significant metabolic pathway distinguishing between depression and schizophrenia groups based on pathway analysis. Conclusively, common alterations in arginine and proline metabolism, alanine, aspartate, and glutamate metabolism were observed in patients with schizophrenia and depression; whereas differences in serum N‐acetylglutamine and isovalerylglycine levels as well as sphingolipid metabolism were discovered between the two categories of patients.
Predicting Swallowing Recovery in Subacute Stroke Patients via Temporal and Spatial Parameters of Videofluoroscopy
Authors: Wang Lian , Wei Zhenhai , Xin Wei , Dou Zulin 
Published: October 2024

ABSTRACTPurposeThe purpose of this study was to identify the temporal and spatial parameters of videofluoroscopic swallowing study (VFSS) that could predict the recovery of swallowing function in subacute stroke patients.MethodsWe included 102 patients who were admitted to the Department of Rehabilitation Medicine between 2019 and 2022. Patients were classified into good and poor prognosis groups according to whether they had restored prestroke swallowing function or were able to consume sufficient nutrition via oral feeding to meet their body's needs. Univariate and multivariate regression analyses were used to identify the predictors. Calibration and discrimination were tested using the Hosmer–Lemeshow test and area under the curve (AUC), respectively.ResultsOf the 102 included patients, 51 had a good prognosis for swallowing function within 6 months of onset. The final multivariate regression model included three significant factors: laryngeal closure duration (LCD) (OR: 0.998; 95% CI: 0.996–0.999; p < 0.05), maximum width of the upper esophageal sphincter opening (MWUESO) (OR: 1.251; 95% CI: 1.073–1.458; p < 0.05), and pharyngeal residual grade (PRG) (p < 0.05). The shorter LCD and larger MWUESO were positive predictors of good swallowing function outcomes, while higher PRG was a negative predictor of good outcomes. The AUC for PRG, MWUESO, and LCD were 0.767 (p < 0.05), 0.738 (p < 0.05), and 0.681 (p < 0.05), respectively.ConclusionIdentifying prognostic factors for the recovery of swallowing function in patients with poststroke dysphagia is essential for developing treatment strategies. The findings of this study may provide an important reference for developing appropriate therapeutic interventions to promote the recovery of swallowing function in stroke patients.
Scientific mapping of green organizational culture: Main schools of thought and topical trends
Authors: Hue Truong Thi , Dinh‐Hai Luong 
Published: October 2024

AbstractThe green transition is increasingly viewed as a path to prosperity, or even survival, for organizations. In several countries, greening is vigorously pursued across various organizational activities, including organizational culture, which has garnered significant scholarly attention. However, there appears to be no comprehensive literature review on green organizational culture (GOC) indexed by reputable databases like Scopus. This paper aims to provide a bibliometric overview of GOC. A total of 558 documents from Scopus, spanning 1996–2023, were analyzed using bibliometric methods. The study examines the research performance on GOC, including volume growth trajectory, document types, contributing countries, international collaboration, research groups, influential authors, and prominent sources in GOC research. Notably, it identifies five main schools of thought and two topical trends in GOC literature. This may be the first effort to review GOC literature using Scopus data, highlighting performance and mapping the scientific landscape of this field.
An Enzymatic Method to Obtain Enantiopure 3‐Pyridyl and Substituted Phenyl Alanine
Authors: Jiang Fan , Chen Ke‐Xin , Xiang Jiang‐Mei , Shen Yong‐Cun 
Published: October 2024

ABSTRACTChiral phenylalanine derivatives are important raw materials and building blocks for the synthesis of peptides and drug molecules. Enantiomerically pure D/L‐3‐pyridyl‐ and phenylalanine has shown wide application potential in the synthesis of various drug intermediates. This article focuses on two synthetic routes from different feedstocks. The first approach is an Erlenmeyer–Plöchl route study using N‐acetylglycine as starting material, whereas the second is an alkylation route study using diethyl acetamidomalonate as starting material. The key step is the resolution of N‐acetamido‐alanine esters using different quantities of fairly inexpensive Protamex proteinase to obtain pure enantiomeric D/L‐3‐pyridyl‐ and substituted phenylalanine or its derivative, with the ee value and purity of all products exceeding 99%. The different chiral arylalanine derivatives that can be prepared using the above two methods have good versatility.
Investigation On Barrier Layers Of PT/BaTiO3/PT Based Thin Film Capacitors
Authors: Smitha P. S. , Suresh Babu V. , Asmin M. K. 
Published: October 2024

AbstractBarium titanate is a ferroelectric material used as a dielectric in thin film capacitors owing to its high dielectric constant. Barrier layers are utilized in these capacitors to improve the capacitors’ performance by controlling the microstructure and creating thin resistive films. In this paper, the effect of barrier layers in Pt/BT/Pt capacitors is studied using zinc oxide and aluminium oxide. The performance parameters such as capacitance density, leakage current, equivalent series resistance, dielectric loss and dielectric strength of Pt/BT/Pt thin film capacitors with barrier layers of different sizes are simulated using COMSOL Multiphysics modeling software. 2 nm thick aluminum oxide as Pt ‐ BT barrier layer gives optimal performance. The leakage current, dielectric loss, capacitance density, equivalent series resistance and dielectric strength of Pt/BT/Pt capacitor are found to be 0.519 mA, 9.62×10−12, 172.8 fF/μm2, 9.62 kΩ, 108 V/m respectively whereas that of Pt/ALO/BT/ALO/Pt capacitor are found to be 1.56×10−18 A, 7.81×10−18, 11.6 fF/μm2, 9.01×1015 Ω, 5.05×109 V/m respectively. The low capacitance in Pt/ALO/BT/ALO/Pt capacitor is due to the low dielectric constant of aluminium dioxide barrier layer. The reduced leakage current and increased equivalent series resistance is due to the low conductivity of the aluminium oxide barrier layer. The use of aluminium oxide barrier layer between the conductive surfaces can reduce the electric field and increase the breakdown voltage, leading to improved dielectric strength and reduced dielectric loss.
An Inductor‐Less Zero‐IF Down‐Conversion Mixer With Low Flicker Noise and High Conversion Gain
Authors: Mallaki Mohammad Amin , Bijari Abolfazl 
Published: October 2024

ABSTRACTThis paper presents a novel active inductor (AI) to improve the performance of a down‐conversion active mixer in terms of conversion gain (CG) and flicker noise. The proposed AI exhibits negative resistance and partially flat inductance over a wide frequency band of 0.5–4.5 GHz. The effect of inserting the AI between the source of the switching quad of a Gilbert cell mixer is theoretically analyzed. The proposed inductor‐less mixer, designed to operate at a 2.4‐GHz RF input frequency and a 10‐MHz IF output frequency, employs current reuse and self‐forward body bias (SFBB) techniques. The proposed circuit is simulated in Cadence Spectre‐RF using RF‐TSMC 0.18‐μm CMOS technology. Post‐layout simulations demonstrate that the proposed AI significantly reduces flicker noise by over 23 dB at an IF output frequency of 1 kHz and improves the CG by over 16 dB at an RF frequency of 2.4 GHz. The proposed mixer achieves a CG of 37.6 dB and a flicker noise corner frequency of 6 kHz. Additionally, it exhibits a third‐order intermodulation intercept point (IIP3) of −5.2 dBm and a double‐sideband noise figure (DSB‐NF) of 6.1 dB at the IF output frequency of 10 MHz. Operating with a 1.5‐V supply, the proposed mixer consumes 10.6 mW of power.
Associations Between Developmental Stability, Canalization, and Phenotypic Plasticity in Response to Heterogeneous Experience
Authors: Wang Shu , Callaway Ragan M. 
Published: October 2024

ABSTRACTThe processes of developmental stability, canalization, and phenotypic plasticity have ecological and evolutionary significance, and been studied extensively, but mostly separately and thus the relationships between them are not straightforward. Our objective was to better integrate these processes in the context of temporally heterogeneous environments. We did this by investigating the effects of early experience with temporal heterogeneity in water availability on associations between developmental stability, canalization, and phenotypic plasticity. We subjected eight plant species to a first round of alternating inundation and drought vs. constantly moderate water treatments (heterogeneous experience) and a second round of water conditions (to test plasticity). We measured fluctuating asymmetry (FA) in leaf size, intra‐ and inter‐individual variation (CVintra and CVinter), and plasticity (PI) in traits and analyzed correlations between these variables across all species. Results showed little correlations between FA, CVintra and PI, several positive correlations between FA and CVinter in more stressful conditions, especially in as well as positive correlations between CVinter and PI initially and negative correlations between them later. These suggested the complexity of these relationships, which can depend on whether plasticity occurs. Greater inter‐individual variation will more likely cooperate with plasticity before or during plastic response, whereas higher canalization may reflect phenotypic convergence. Both higher FA and CVintra can reflect faster growth, while CVintra may also reflect plant growth stage, and the two mechanisms should cooperate in response to environmental challenges. The complexity of these relationships suggests plants deal with environmental variation in elaborate and integrative ways which can be affected by many factors.
Projecting the benefit of vericiguat in PARADIGM‐HF and DAPA‐HF populations: Insights from the VICTORIA trial
Authors: Kittipibul Veraprapas , Mentz Robert J. , Young Rebecca , Butler Javed , Ezekowitz Justin A. , Lam Carolyn S.P. , Ponikowski Piotr , Voors Adriaan , Corda Stefano , McMullan Ciaran , O'Connor Christopher M. , Anstrom Kevin J. , Armstrong Paul W. ,   for the VICTORIA Study Group
Published: October 2024

AbstractAimsThe VICTORIA trial demonstrated a significant reduction in the primary composite outcome of heart failure (HF) hospitalization or cardiovascular death with vericiguat relative to placebo in high‐risk HF. This study aimed to contextualize treatment effects of vericiguat in populations with varying risk profiles simulated from the PARADIGM‐HF and DAPA‐HF trials.MethodsSubgroups of VICTORIA participants (n = 5050) were generated to simulate PARADIGM‐HF and DAPA‐HF trial populations. The PARADIGM‐HF‐eligible population excluded participants not meeting left ventricular ejection fraction (LVEF), estimated glomerular filtration rate (eGFR), and minimal dose criteria and those with high predicted probability of run‐in failure. The DAPA‐HF‐eligible population excluded those not meeting LVEF and eGFR criteria or with recent (<30 days) HF hospitalization. The time‐to‐first‐event analysis was performed using an unadjusted Cox proportional hazards model.ResultsA total of 1982 (39.2%) and 2543 (50.4%) VICTORIA participants were respectively deemed eligible for PARADIGM‐HF and DAPA‐HF. Vericiguat was associated with numerically larger reductions in the primary outcome of HF hospitalization or cardiovascular death in populations simulated from PARADIGM‐HF [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.72–0.99] and DAPA‐HF (HR 0.82, 95% CI 0.71–0.94) compared with the overall VICTORIA trial (HR 0.90). Significant reduction in HF hospitalization with vericiguat was also observed in the DAPA‐HF‐eligible population (HR 0.83, 95%CI 0.73–0.95) and with a nominal reduction in the PARADIGM‐HF‐eligible population (HR 0.86, 95% CI 0.74–1.01).ConclusionsA trend towards enhanced efficacy of vericiguat in populations simulated from PARADIGM‐HF and DAPA‐HF was observed. These findings support further exploration of vericiguat in lower‐risk HF populations as is being investigated in the ongoing VICTOR (a study of vericiguat in participants with chronic heart failure with reduced ejection fraction) trial.
Excitation Dependent Multiemissive Behaviour of Triimidazole Carboxylic Acid anti‐Kasha Luminophore and its Mononuclear Metal Complexes
Authors: Malpicci Daniele , Forni Alessandra , Lucenti Elena , Marinotto Daniele , Maver Daniele , Lozovan Vasile , Kravtsov Victor C. , Siminel Anatolii , Fonari Marina S. , Cariati Elena 
Published: October 2024

AbstractMaterials based on small molecules characterized by multi‐component short and long‐lived emissive behaviour are extremely desirable for various applications. The derivative of cyclic triimidazole (TT) functionalized with a carboxylic group, namely TT‐COOH, is isolated, investigated and used as coordinative ligand to obtain a series of isomorphous mononuclear complexes of general formula [M(TT‐COO)2(H2O)2] (M=Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II)). Crystals of TT‐COOH display aggregation induced enhanced emission (AIEE) comprising dual fluorescence and dual phosphorescence of molecular origin together with an aggregation induced long lived, low energy phosphorescence. Emissive features are retained in crystals of the Zn(II) and Cd(II) complexes, where the metal plays the role of an external heavy atom perturber, but strongly quenched in the others. The mechanisms involved in the photophysics of TT‐COOH and its metal complexes have been disclosed thanks to combined structural, spectroscopic and computational investigations which reveal the presence of anti‐Kasha emissions.
Iron and Zinc Metallates Supported on Ion Exchange Resins: Synergistic Catalysts for the Solvent‐Free Cyclic Carbonate Synthesis from Epoxides and CO2
Authors: Alberti Matteo , Gianelli Marta , Panza Nicola , Zákutná Dominika , Matulková Irena , Caselli Alessandro 
Published: October 2024

AbstractDespite extensive research into developing efficient and environmentally friendly catalysts for converting CO2 over the last decade, the search for a robust and cost‐effective catalytic system is ongoing. This study describes developing and applying a new catalytic system using inexpensive ferrate and zincate anions immobilized on easily available commercial ion exchange resins (IER) to produce cyclic carbonates from CO2 with high efficiency and low cost. Two polystyrene‐based anion exchange resins, AmberlystTM A26‐Cl (A26‐Cl) and AmberliteTM IRA‐400‐Cl (IRA400‐Cl), were compared. The results demonstrated the catalysts’ remarkable activity under mild conditions and demonstrated the synergistic effect between the polystyrene support and the active ammonium metallates, presenting a scalable, eco‐friendly method for cyclic carbonate production using waste CO2. A Design of Experiment (DoE) approach was implemented to optimize the catalytic cycloaddition of CO2. The reaction scale‐up to produce a 5 g batch of propylene oxide and conducting recycling tests demonstrated that the catalyst retained its activity over four cycles. The research also explored the use of various epoxides and found that terminal epoxides produced very good yields. In summary, this study introduces a cost‐effective, scalable method for converting CO2 into valuable cyclic carbonates, leveraging the synergistic effects of polystyrene supports and active ammonium metallates.
The antipsychotic chlorpromazine reduces neuroinflammation by inhibiting microglial voltage‐gated potassium channels
Authors: Lee Hee‐Yoon , Lee Young , Chung Chaelin , Park Seo‐In , Shin Hyo Jung , Joe Eun‐Hye , Lee Sung Joong , Kim Dong Woon , Jo Su‐Hyun , Choi Se‐Young 
Published: October 2024

AbstractNeuroinflammation, the result of microglial activation, is associated with the pathogenesis of a wide range of psychiatric and neurological disorders. Recently, chlorpromazine (CPZ), a dopaminergic D2 receptor antagonist and schizophrenia therapy, was proposed to exert antiinflammatory effects in the central nervous system. Here, we report that the expression of Kv1.3 channel, which is abundant in T cells, is upregulated in microglia upon infection, and that CPZ specifically inhibits these channels to reduce neuroinflammation. In the mouse medial prefrontal cortex, we show that CPZ lessens Kv1.3 channel activity and reduces proinflammatory cytokine production. In mice treated with LPS, we found that CPZ was capable of alleviating both neuroinflammation and depression‐like behavior. Our findings suggest that CPZ acts as a microglial Kv1.3 channel inhibitor and neuroinflammation modulator, thereby exerting therapeutic effects in neuroinflammatory psychiatric/neurological disorders.
Perceived parental prejudice and a tolerant class context in ethnic bullying: The buffering role of teachers
Authors: Taiti Maria Chiara , Palladino Benedetta Emanuela , Stefanelli Federica , Özdemir Sevgi Bayram , Menesini Ersilia 
Published: October 2024

AbstractIntroductionDespite recent efforts to understand the possible impact of contextual factors on adolescents’ involvement in ethnic bullying, most existing studies have focused on the effects of one context at a time. As adolescents are simultaneously exposed to the influence of multiple socialization agents, the aim of this study was to investigate whether teachers’ and classmates’ tolerance towards ethnic minorities could buffer the effect of perceived parental prejudice on adolescents’ involvement in ethnic bullying.MethodsData were collected between January and February 2020 from 9th grade adolescents (N = 582; Mage = 15.23; SD = 0.65; 50.9% female; 30.7% with an immigrant background), and their teachers (N = 72; aged between 27 and 65 years; 79% female), belonging to 37 classrooms located in Italy.ResultsA cross‐sectional multilevel analysis showed that teachers’ tolerance moderated the effect of perceived parental prejudice on adolescents’ involvement in ethnic bullying. Specifically, we found that in classrooms with low levels of teachers’ tolerance, perceived parental prejudice was significantly associated with students’ involvement in ethnic bullying. Conversely, in classrooms with high levels of teachers’ tolerance, parental prejudice was no longer associated with ethnic bullying. Furthermore, classmates’ tolerance was not significantly associated with students’ involvement in ethnic bullying and did not moderate the association between perceived parental prejudice and adolescents’ engagement in ethnic bullying.ConclusionsFindings are discussed highlighting the important role of school as a context to promote positive multicultural relations and the unique role played by teachers in affecting adolescents’ behaviors.
Interobserver Reproducibility of Ultrasound Attenuation Imaging Technology in Liver Fat Quantification
Authors: Dag Nurullah , Igci Gulnur , Yagin Fatma Hilal , Hanci Muhammed Salih , Kutlu Ramazan 
Published: October 2024

ABSTRACTPurposeThis study aims to investigate the interobserver variability in the quantitative assessment of liver fat content using ultrasound attenuation imaging technology (USAT).MethodsThis prospective, single‐center study included 96 adult patients who were either diagnosed with or suspected of having metabolic dysfunction‐associated steatotic liver disease. Independent observers, blinded to each other's assessments, evaluated hepatic steatosis visually and through USAT measurements. Separate measurements were taken at five intercostal and subcostal sites, and the median values of these measurements were recorded. The correlation between USAT measurements and visual steatosis grades was examined using Spearman's correlation test. Intraclass correlation coefficient (ICC) and Bland–Altman analysis were used to evaluate the interobserver variability of USAT measurements.ResultsInterobserver agreement for USAT measurements was excellent for the intercostal examination and good for the subcostal examination (p < 0.001). Body mass index did not significantly affect the level of interobserver agreement. Interobserver variability in Bland–Altman plots of USAT measurements was within the 95% limits of agreement. USAT measurements correlated very strongly with the visual degree of hepatic steatosis, both intercostal and subcostal (p < 0.001). USAT measurements were also significantly different between different visual degrees of hepatic steatosis (p < 0.001).ConclusionIn the assessment of hepatic steatosis, USAT measurements obtained from the intercostal space showed excellent agreement in terms of interobserver reproducibility.