bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart failure in Europe: Guideline‐directed medical therapy use and decision making in chronic and acute, pre‐existing and de novo, heart failure with reduced, mildly reduced, and preserved ejection fraction – the ESC EORP Heart Failure III Registry
Authors: Lund Lars H. , Crespo‐Leiro Maria Generosa , Laroche Cécile , Zaliaduonyte Diana , Saad Aly M. , Fonseca Candida , Čelutkienė Jelena , Zdravkovic Marija , Bielecka‐Dabrowa Agata M. , Agostoni Piergiuseppe , Xuereb Robert G. , Neronova Kseniya V. , Lelonek Malgorzata , Cavusoglu Yuksel , Gellen Barnabas , Abdelhamid Magdy , Hammoudi Naima , Anker Stefan D. , Chioncel Ovidiu , Filippatos Gerasimos , Lainscak Mitja , McDonagh Theresa A. , Mebazaa Alexandre , Piepoli Massimo , Ruschitzka Frank , Seferović Petar M. , Savarese Gianluigi , Metra Marco , Rosano Giuseppe M.C. , Maggioni Aldo P. ,   for the ESC EORP HF III National Leaders and Investigators
Published: September 2024

AbstractAimsWe analysed baseline characteristics and guideline‐directed medical therapy (GDMT) use and decisions in the European Society of Cardiology (ESC) Heart Failure (HF) III Registry.Methods and resultsBetween 1 November 2018 and 31 December 2020, 10 162 patients with acute HF (AHF, 39%, age 70 [62–79], 36% women) or outpatient visit for HF (61%, age 66 [58–75], 33% women), with HF with reduced (HFrEF, 57%), mildly reduced (HFmrEF, 17%) or preserved (HFpEF, 26%) ejection fraction were enrolled from 220 centres in 41 European or ESC‐affiliated countries. With AHF, 97% were hospitalized, 2.2% received intravenous treatment in the emergency department, and 0.9% received intravenous treatment in an outpatient clinic. AHF was seen by most by a general cardiologist (51%) and outpatient HF most by a HF specialist (48%). A majority had been hospitalized for HF before, but 26% of AHF and 6.1% of outpatient HF had de novo HF. Baseline use, initiation and discontinuation of GDMT varied according to AHF versus outpatient HF, de novo versus pre‐existing HF, and by ejection fraction. After the AHF event or outpatient HF visit, use of any renin–angiotensin system inhibitor, angiotensin receptor–neprilysin inhibitor, beta‐blocker, mineralocorticoid receptor antagonist and loop diuretics was 89%, 29%, 92%, 78%, and 85% in HFrEF; 89%, 9.7%, 90%, 64%, and 81% in HFmrEF; and 77%, 3.1%, 80%, 48%, and 80% in HFpEF.ConclusionUse and initiation of GDMT was high in cardiology centres in Europe, compared to previous reports from cohorts and registries including more primary care and general medicine and regions more local or outside of Europe and ESC‐affiliated countries.
Three Metal Complex‐Decorated Halobismuthates: Syntheses, Structures, Semiconducting Behaviors and Theoretical Investigations
Authors: Xie Shu‐Yue , Li Bao‐Han , Li Jia‐Qi , Dong Jiu‐Jiang , Ren Xiao‐Chen , Zhang Bo , Li Jun , Huang Xiao‐Ying 
Published: September 2024

AbstractEmploying metal complex cations as the structural modifiers, three new numbers of hybrid halobismuthates family, namely [NH4][Co(phen)3]BiI6 (phen=1,10‐phenanthroline; 1), [Zn(phen)2Br][Bi(phen)Br4] ⋅ H2O (2) and [Cu(2,2′‐bipy)2Br][Cu(2,2′‐bipy)2Bi2Br9] ⋅ H2O (2,2′‐bipy=2,2′‐bipyridine; 3) have been solvothermally constructed and structurally characterized. X‐ray crystallography analyses show that all compounds characteristic of abundant weak interactions feature the discrete anionic motifs. The obtained hybrid materials possess the semiconducting nature, with the visible light responding optical band gaps of 2.13–2.71 eV. Under the alternating light irradiation, they exhibit excellent photoelectric switching properties, whose photocurrent densities (0.85, 0.24, and 0.43 μA/cm2 for compounds 1–3, respectively) compare well with some high‐performance halobismuthate competitors. Further theoretical calculations of compound 1 reveal that the photosensitive [Co(phen)3]2+ cations contribute greatly to the bottom of conduction bands (CBs) and the top of valence bands (VBs), which may be the important reason for its excellent photoelectric behavior. The analyses of Hirshfeld surface, thermal stability, and X‐ray photoelectron spectroscopy were also discussed detailedly in this paper.
Synthesis and Structural Characterization of Haloaryl N‐Substituted Sugar Derivatives
Authors: Rengel Natividad Bejarano , Esteche Juliana , Echeverría Gustavo A. , Piro Oscar E. , Santiago Cintia C. , Ponzinibbio Agustín 
Published: September 2024

AbstractWe present here the efficient preparation of 6‐N‐haloaryl‐galactosides through a reductive amination process. A complete set of 6‐deoxy‐1,2;3,4‐di‐O‐isopropylidene‐6‐N‐phenylamino‐α‐D‐galactopyranosides were obtained with a straightforward method. The products were structurally analyzed by X‐ray diffraction techniques and NMR spectroscopic data. A complete investigation of the galactosyl derivatives is described, including an unexpected N,N'‐diphenylamino by‐product. Moreover, relevant conformational aspects in solution and in the solid state are identified and discussed.
Comparative prognosis analysis of ovarian squamous cell carcinoma versus serous carcinoma: Insights from the SEER database
Authors: Nie Xianglin , Xu Ting , Cheng Wenjun 
Published: September 2024

AbstractObjectiveThe aim of this study was to identify survival rates and potential prognostic factors of ovarian squamous cell carcinoma (OSCC), offering valuable insights for clinical decision making.MethodsLeveraging the Surveillance, Epidemiology, and End Results (SEER) database, we selected 11 078 serous carcinoma (SC) patients and 198 OSCC patients based on predetermined criteria diagnosed from 2000 to 2020. We compared the overall survival (OS) and cancer‐specific survival (CSS) before and after propensity score matching (PSM) in two groups. Prognostic differences were also compared between OSCC and SC groups at different stages. Univariate and multivariate Cox regression analyses were performed to investigate the impact of clinical and pathologic variables on the survival of patients with OSCC. Finally, we developed and validated a nomogram predictive model.ResultsOSCC tumors exhibited distinct characteristics, being relatively larger, more frequently unilateral, and better differentiated than SC tumors. After PSM, Kaplan–Meier analysis revealed significantly lower survival rates for OSCC patients in Stages IIB–IV, while Stages IA–IC displayed comparable survival. Independent risk factors for OSCC patients included advanced age, single marital status, higher tumor stage, and increased tumor size. Conversely, higher median household income and chemotherapy emerged as independent protective factors. Our predictive model and nomogram accurately forecasted patient survival rates in both SEER and internal validation datasets.ConclusionOSCC patients face significantly poorer prognosis than their SC counterparts, except in the very early stages. Higher median household income was associated with better OSCC survival.
Ultrasonographic assessment of the fetal heart in intrahepatic cholestasis of pregnancy: Pulsed wave Doppler, M‐mode, and tissue Doppler imaging prospective study
Authors: Agaoglu Zahid , Tanacan Atakan , Toptas Gulnihal Reyhan , Akgun Aktas Betul , Gulen Yildiz Esra , Kara Ozgur , Sahin Dilek 
Published: September 2024

AbstractObjectivesTo investigate the fetal heart using pulsed wave Doppler, M‐mode, and tissue Doppler imaging (TDI) in cases of intrahepatic cholestasis of pregnancy (ICP).MethodsThis prospective study was conducted at a single tertiary center and included 35 patients with ICP and 70 healthy pregnant women at 28–36 weeks of pregnancy. Among the patients with ICP, 26 had serum bile acid (SBA) levels less than 40 μmol/L and nine had SBA levels of 40 μmol/L or greater. Pulsed wave Doppler, M‐mode, and TDI evaluations were performed on the patients to assess fetal cardiac function.ResultsThe ICP group exhibited significantly higher myocardial performance index (MPI) and isovolumetric relaxation time (IRT), but similar isovolumetric contraction time (ICT). The tricuspid and mitral valve E, A, and E/A ratios were significantly reduced in the ICP group. The TDI parameters showed significantly reduced tricuspid and mitral valve E′/A′ ratios in the ICP group compared with the control group (P < 0.001). The E/E′ ratio was significantly increased in the ICP group (P < 0.001). According to the M‐mode Doppler findings, tricuspid and mitral annular plane systolic excursion values were significantly decreased in the ICP group (P = 0.005 and P = 0.001, respectively). In the subgroup analysis, MPI and IRT were significantly higher in the severe ICP group.ConclusionICP might induce changes in the fetal heart during the early systolic and diastolic phases. The detection of these early changes using M‐mode and TDI during the antenatal period can provide valuable insights into the condition of the fetus.
When the microbiome meets One Health principle: Leading to the Holy Grail of biology and contributing to overall well‐being and social sustainability
Authors: Zhou Yazhou , Xu Ziying , Zhang Huan , Liu Teng , Zhou Jin , Bi Yujing , Han Yanping , Tan Yafang , Yuan Jing , Yang Ruifu 
Published: September 2024

AbstractThe convergence of microbiome science with the One Health principle heralds a transformative era in biology, prioritizing the collective well‐being of humans, animals, and the environment. This review delves into the intricate dance between microbiomes and their hosts, revealing their profound impact on health, nutrient cycles, and climate change. Championing a unified approach to health issues across diverse kingdoms of life, One Health emerges as a holistic strategy, underscored by a proposed universal balance theory, “Balance of Dynamic Factors.” This theory spotlights the equilibrium within microbial and human‐animal‐environment interactions, offering a revolutionary pathway to global health and social well‐being. It paves the way for disease prevention, health equity, and sustainability, all of which are purviews of a balanced ecological system. We navigate the challenges and opportunities of this integrative approach, culminating in a call for action for the incorporation of microbiome science into health policies, precision medicine, legislation, eco‐health projects, and education, thereby setting the stage for harmonious coexistence with our planet.
Millennials' identity in hospitality and tourism: A systematic review with qualitative framework synthesis
Authors: Papavasileiou Emmanouil F. , Stergiou Dimitrios 
Published: September 2024

AbstractThis study introduces framework synthesis as an encompassing orientation for drawing conclusions from evolving and/or complex topics in the practice of systematic reviews in hospitality and tourism (H&T). To illustrate this emerging approach, we use the topic of Millennials' identity in the H&T workplace, guided by the review question: How do Millennials perceive aspects of the H&T workplace? The search for relevant literature focused on peer‐reviewed English language articles and dissertations that included relevant qualitative data. The multisource search strategy in prior reviews, the Scopus database, and Google Scholar (04/01/2023) generated 480 records. Each record was independently screened for eligibility by the authors, and any disagreements were resolved through discussion and consensus. This process identified 20 eligible studies representing an international, multisector, and multidisciplinary stream of qualitative research published between 2005 and 2022. The included data were extracted in a thematic framework that synthesized Millennials' identity as cognitive, evaluative, and emotional perceptions of aspects of the H&T workplace. Intragenerational heterogeneity appears in some instances based on nationality and career stage, raising implications for practitioners. Given language limitations, we call for more systematic reviews that translate into non‐English publications to make this stream of research globally accessible to scholars.
Preparation of fern root resistant starch by pullulanase and glucoamylase combined with autoclaving‐enzymatic method: physicochemical properties and structural characterization
Authors: Huang Min , Li Li , Lei Guoqing , Qiu Ran , Wang Yi , Wu Jianhang , Zong Xuyan 
Published: September 2024

AbstractBACKGROUNDFern root starch has a high percentage of amylose and has great potential for application in the field of slow‐digesting foods. Clarifying the effect of treatment conditions on fern root starch is key to achieving industrialized production of fern root resistant starch. In the present study, fern root starch was treated by the autoclave‐enzymatic method with pullulanase, glucoamylase and mixed enzyme.RESULTSThe content of resistant starch in fern roots treated with mixed enzyme was the highest (24.07 ± 1.11%), which was approximately 320% times that of the native starch, had the best water‐holding capacity (151.08%), vital transparency and freeze–thaw stability. By contrast, the solubility, swelling and viscosity were lower than natural starch. In addition, mixed enzyme shows a denser structure, and the crystal form changes from C‐type to V‐type, with a high relative crystallinity and significantly enhanced thermal stability.CONCLUSIONAfter mixed enzyme combined with autoclave treatment, the content of resistant starch in fern root was greatly increased. The modified starch molecules did not produce new functional groups, which made the crystal structure of starch molecules more compact, and resistance to enzymatic hydrolysis and high temperature thermal stability were significantly enhanced. This provides a positive reference for further in‐depth study of fern root starch, improvement of utilization value, development and innovation of new food health products, and diabetes treatment. © 2024 Society of Chemical Industry.
A Systematic Review of Surgical and Pathological Outcomes in Patients With a CDH1 Mutation Undergoing Total Gastrectomy
Authors: Khiabany Atousa , Dermanis Alexander A. , Liew Mei Sien , Ong Kai Ren , Kamarajah Sivesh K. , Griffiths Ewen A. 
Published: September 2024

ABSTRACTBackgroundCDH1 (E‐cadherin) genetic mutations are associated with a 30%−70% increased lifetime risk of hereditary diffuse gastric cancer (HDGC). Although prophylactic total gastrectomy (PTG) reduces long‐term risk of gastric cancer, the associated morbidity and mortality remain unclear. This systematic review aims to characterise postoperative surgical outcomes in patients undergoing total gastrectomy.MethodsA systematic literature search was performed for studies reporting endoscopic surveillance, surgical and pathological outcomes for patients with CDH1 mutation undergoing a total gastrectomy.ResultsThirty‐nine studies included 1849 patients, of which 96% had a CDH1 (n = 1777) or CTNNA1 (n = 3) mutation. Endoscopy outcomes were reported for 1640 patients. Cancer foci were identified in 32% (n = 523/1640) and 71% of these patients went on to have a total gastrectomy (n = 369/523). The remaining 78% of patients did not have cancer foci detected on endoscopy (n = 1117/1640). Of these patients, 62% underwent a total gastrectomy (n = 688/1117) and 81% were found to have cancer on surgical histology (n = 556/688). Pathological staging was reported for 790 patients undergoing surgery, of which 68% had pT1 disease (n = 537). Postoperative complications were reported for 430 patients across 23 studies, with the most common complications being anastomotic strictures (25%), anastomotic leaks (13%), wound infections (12%) and pulmonary complications (11%). Only one postoperative death was reported within 30 days.ConclusionRates of early cancers are high in CDH1 patients undergoing PTG, highlighting the need for improvement in reliable endoscopic surveillance. Although postoperative mortality in this surgical cohort remains low, high rates of postoperative complications warrant careful patient counselling.
Systematic Review of Robotic‐Assisted Peripheral and Central Lymphatic Surgery
Authors: Carlotta Imholz , Lisanne Grünherz , Nicole Lindenblatt 
Published: September 2024

ABSTRACTBackgroundRobotic‐assisted lymphatic reconstruction has gained increasing interest over the past few years.ObjectivesThe aim of this study was to systematically investigate the benefits of robotic‐assisted lymphatic surgery based on currently published literature.MethodsA systematic review evaluating the feasibility, surgical aspects, and both objective and subjective improvements in patients with impairment of the peripheral or central lymphatic system was performed according to the PRISMA guidelines. The review was registered on PROSPERO.ResultsThe literature search yielded 328 articles after the removal of duplicates, followed by a full‐text review of the 29 articles, out of which a total of 11 relevant articles were deemed eligible. Among these, seven used a retrospective design and four a prospective design. All studies included confirmed the feasibility of robotic‐assisted lymphatic surgery and reported promising results concerning both technical aspects and patient‐related outcomes. However, currently, only a limited number of studies directly compare the robotic‐assisted approach to the manual approach, and these studies have limited statistical analyses.ConclusionDespite the heterogeneous measurands, all studies showed the feasibility of robotic‐assisted lymphatic surgery, and seven provided promising data on patient‐related outcomes. Additional studies are needed to further identify future directions in robotic‐assisted lymphatic surgery.
The analysis of e‐liquids: A study on chemical diversity and metal content using gas chromatography‐mass spectrometry and inductively coupled plasma‐mass spectrometry
Authors: Rantaša Matjaž , Majer David , Finšgar Matjaž 
Published: September 2024

This work aimed to determine the chemical composition of 22 e‐liquids available on the Slovenian market. Four different gas chromatography (GC) sample introduction techniques; headspace‐GC‐mass spectrometry (HS‐GC‐MS), liquid injection‐GC‐MS (LI‐GC‐MS), HS‐solid‐phase microextraction‐GC‐MS (HS‐SPME‐GC‐MS), and direct‐immersion‐SPME‐GC‐MS (DI‐SPME‐GC‐MS) were employed for qualitative analysis. Various experimental parameters were assessed for each GC sample introduction technique to maximize compound identification. Despite e‐liquid packaging reporting a maximum of eight compounds, GC‐MS identified more compounds in most samples, especially in menthol‐flavored (58 identifiable compounds by HS‐SPME‐GC‐MS), followed by nicotine‐containing and fruit‐flavored samples. HS‐SPME‐GC‐MS identified the highest number of compounds, followed by HS‐GC‐MS, DI‐SPME‐GC‐MS, and LI‐GC‐MS. Nicotine quantification in six samples was performed by LI‐GC‐MS with dilution in methanol. Nicotine concentration in samples ranged from 16.5 ± 0.5 to 18.5 ± 0.4 mg/mL, which was below the declared concentration of 20 mg/mL. Additionally, quantitative analysis of metals in e‐liquids was performed by inductively coupled plasma‐MS after microwave‐assisted wet acid digestion. Iron was the most abundant metal, with its content ranging from 0.024 to 0.354 µg/g. Barium, bismuth, copper, and tin were also determined in several e‐liquids.
Multiscale Glass Fiber/Epoxy Nanocomposites Incorporated with Graphene and Zinc Oxide Nanoparticles: Enhanced Mechanical Properties
Authors: Dev Barshan , Nipu Shah Ashiquzzaman , Rahman Md Ashikur , Mahmud Khondokar Raihan , Riyad Maksudur Rahman , Rahman Md Zillur 
Published: September 2024

AbstractThis study fabricates multiscale glass fiber/epoxy composites by incorporating graphene nanoparticles (GNPs) and zinc oxide nanoparticles (ZnO NPs) to investigate the influences of NPs on the mechanical properties of composites. The composites are manufactured using the compression molding technique with different GNP contents (i.e., 0, 0.5, 1, and 1.5 wt.%), whereas the contents of glass fibers and ZnO NPs remained the same at 40 and 4 wt.%, respectively. Their mechanical properties, chemical compositions, and fracture morphologies are then evaluated. It is found that the mechanical properties of composites improve significantly at a lower content (i.e., 0.5 wt.%) of GNPs and tend to decrease at higher contents (i.e., 1 and 1.5 wt.%). The composite is composed of 0.5 wt.% GNPs exhibit maximum tensile modulus and strength of 6.74 GPa and 230.25 MPa, and flexural modulus and strength of 16.43 GPa and 831.79 MPa, respectively, impact strength of 47.25 kJ m−2, and maximum hardness (97.96 Shore D), among all nanocomposites. Moreover, fracture morphologies reveal that composite failure is predominately caused by fiber breakage, fiber‐matrix debonding, voids, and GNP agglomeration. The outcomes of this study provide some insights to promote the application of manufactured multiscale composites in the aerospace, automotive, and marine industries.
From Angiosomal to Bi‐Angiosomal and Extra‐Angiosomal Pedicled Perforator Flaps: Optimizing the Use of Local Tissues in Abdominal Wall Reconstruction
Authors: Brunetti Beniamino , Morelli Coppola Marco , Petrucci Valeria , Pazzaglia Matteo , Camilloni Chiara , Putti Alessandra , Salzillo Rosa , Tenna Stefania , Cagli Barbara , Persichetti Paolo 
Published: September 2024

ABSTRACTIntroductionThe use of free‐style and propeller perforator‐based flaps has been popularized for the reconstruction of moderate size defects in the trunk and extremities, while their application in the field of abdominal reconstruction is seldom reported. The purpose of this report is to describe the authors experience with the use of pedicled perforator‐based flaps in abdominal wall reconstruction, presenting the innovative concept of transition from angiosomal to bi‐angiosomal and extra‐angiosomal perforator flaps and showing applications of the different flap designs according to the multiple clinical scenarios.Patients and MethodsA total of 15 patients underwent abdominal wall reconstruction with angiosomal, bi‐angiosomal, and extra‐angiosomal pedicled perforator‐based flaps harvested from the surrounding abdominal subunits for superficial or full thickness defects of the abdominal wall of moderate and large dimensions. The defects were consequent to soft‐tissue sarcomas (STS) and non‐melanoma skin cancer (NMSC) resection in 11 and 4 cases, respectively. Operative data, post‐operative course, and complications were recorded. Moreover, at 12 months follow‐up, patients were asked to rate the esthetic and functional outcomes of the reconstructive procedure on a 5‐point Likert scale.ResultsTen angiosomal perforator flaps (4 DIEP, 4 SCIP, 1 SEAP, and 1 LICAP flaps) and 5 bi‐angiosomal and extra‐angiosomal conjoined perforator flaps including different vascular territories (3 bilateral DIEP, 1 bilateral SEAP, and 1 ipsilateral DIEP‐SEAP flap) were successfully transferred in 15 patients. In two patients, microsurgical anastomoses were performed to guarantee proper vascularization of the additional cutaneous territory. Mean age was 59.3 years. Defect sizes ranged from 98 to 408 cm2 (mean size was 194.7 cm2). Mean operative time was 280 min. Flap surface ranged from 108 to 336 cm2 (mean surface was 209.3 cm2). No major complications were registered. One bi‐angiosomal bilateral DIEP flap suffered from partial necrosis and required an additional flap reconstruction. All patients underwent a 12‐month follow‐up except one, who did not show for clinical follow‐up but responded at the Likert scale at clinical follow‐up at 9 months. Overall patients' satisfaction was high, with mean esthetic and functional ratings of 4.27 and 3.87.ConclusionThe use of local tissues is an under‐utilized solution in the field of abdominal wall reconstruction. Angiosomal, bi‐angiosomal, and extra‐angiosomal perforator flaps proved to be a reliable option to provide the transfer of a significant amount of tissue and offer like with like reconstruction while maximizing flap survival.