bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperglycemia-induced oxidative-stress, apoptosis, and embryopathy
Authors: Miller Robert 
Published: August 2016

AbstractAs the incidence of both type-1 and type-2 diabetes increases, more diabetes-related complications are being observed in pediatric patients. However, some diabetes-related issues in pediatric patients may be a carry-over or consequence of gestational or fetal diabetes. Elevated maternal glucose levels have been associated with increased incidence of spontaneous abortions, perinatal mortality, stillbirths, and congenital malformations. A few of these congenital malformations (embryopathy) in both humans and animals include skin discoloration; webbed toes; cleft lips and palates; congenital heart defects; and neural tube defects. While neural tube defects and congenital heart defects are the most frequent consequence of embryonic / fetal hyperglycemia, hyperglycemia-induced hepatic and renal developmental problems are also known. Hyperglycemia-induced embryopathy has been associated with reduced cell proliferation, oxidative-stress, increased rates of lipid peroxidation coupled with increased homocysteine levels, and apoptosis. Consequently, this review discusses embryonic hyperglycemia-induced reduced embryo viability, increased rates of oxidative-stress, increased lipid peroxidation rates coupled with elevated homocysteine levels, and increased apoptosis rates.
Management of sodium metabolism derangements in children treated for hypothalamic-hypophyseal tumors
Authors: Tuli Gerdi , Verna Francesca , Tessaris Daniele , Fiore Ludovica , Mussa Alessandro , Repici Marialia , Lala Roberto , Matarazzo Patrizia 
Published: August 2016

AbstractHyponatremia and hypernatremia, common electrolyte abnormalities in children hospitalized for intracranial diseases, are life-threatening events. Diagnosis and adequate treatment of hypo- and hypernatremia are mandatory to prevent neurological sequelae. We report ante-and post-hypophyseal dysfunctions, disabilities and acute sodium metabolism derangements in 16 children affected by hypothalamic-hypophyseal tumors treated by neurosurgery and/or chemotherapy during a long-lasting follow-up. We compare acute hypo- and hypernatremic episodes during surgery between these patients, treated with a specific hormonal and infusive protocol (protocol A), and a previous cohort of patients, affected by similar tumors, treated with a previously published protocol (protocol B). All patients showed multiple or isolated pituitary dysfunctions and disabilities before chemotherapy and/or surgical treatment that worsened during the follow-up period. We found a statistical significant decrease of hyponatremic intra-operative acute events in children treated with protocol A. Sodium metabolism derangements complicating the course of hypothalamic-hypophyseal tumors can be partially prevented with specific per-operative protocols. Aim of this study is to present a new sodium metabolism derangements management in children treated for hypothalamic-hypophyseal tumors and to compare this with a previous one.
Characteristics of metabolic acidosis and management of rotavirus gastro-enteritis
Authors: Dhelaria Anshoo , Commondoor Raghuram , Kar Ananya , Eisenhut Michael 
Published: August 2016

AbstractObjectives of this study were to investigate the characteristics of metabolic acidosis associated with rotavirus gastroenteritis and to explore them as a tool in the management of dehydration. The study was retrospective, case record based and conducted in a secondary level District General Hospital. Included study population were 133 children who were admitted to the Paediatric Unit with rotavirus gastroenteritis. Degree of dehydration, result of blood gas analysis, C-reactive protein level, urinary ketones, renal function tests, fluid management and duration of hospitalization were recorded and results compared between patients with and without severe metabolic acidosis (serum bicarbonate < 17 mmol/L). Out of 133 patients, blood gas analysis was obtained in 78 (59%) and 73 (94%) of those showed metabolic acidosis (bicarbonate < 22 mmol/L). Thirty five patients developed severe metabolic acidosis. Patients with severe metabolic acidosis showed signs of dehydration more commonly (97% vs. 74%, p < 0.05) and required intravenous rehydration more frequently (94% vs. 63%, p < 0.05) than those who were not severely acidotic. With respect to gender ratio, initial temperature, serum levels of C-reactive protein, chloride, anion-gap, lactate and ketonuria, there were no significant differences between the severely acidotic patients and those who were not. Urea and creatinine levels were higher (46.6 (11.7) versus 37.8 (11.9) micromole/L for creatinine and 5.5 (1.9) versus 4.2 (2.1) mmol/L for urea, p < 0.05) in patients with severe metabolic acidosis and correlated significantly negatively (for both: r = − 0.29, p = 0.02) with serum bicarbonate levels. We concluded that the majority of children attending hospital with rotavirus gastroenteritis had a metabolic acidosis. Severe metabolic acidosis was associated with more severe dehydration and higher urea and creatinine levels and increased requirement for intravenous fluid boluses and intravenous rehydration. A bicarbonate level of > 17 mmol/L excluded severe clinical dehydration and below this level a degree of dehydration was very likely.
Negotiating “meaningful participation” for Indigenous peoples in the context of mining
Authors: Ruwhiu Diane , Carter Lynette 
Published: August 2016

Purpose
This paper aims to explore the importance of meaningful participation for Indigenous peoples within the complex and highly political context of mining and mineral extraction. The aim is to consider the multi-dimensional nature of the mining context that takes into account the discursive landscape that frames the often disparate perspectives of corporate, state and Indigenous communities.

Design/methodology/approach
The paper is a conceptual offering that examines the complex environment within which “meaningful participation” between mining corporates and Indigenous communities operate.

Findings
This paper highlights the multi-dimensional nature of a proposed relationship between the mining corporates, the state and the Indigenous Māori community within New Zealand. The facilitation of “meaningful participation” requires that any negotiated agreement is undertaken within a framework of meaning that makes sense to the Indigenous community, in addition to the appropriate legislative and corporate initiatives to be in place.

Originality/value
The paper highlights the complex considerations that must be included in any form of negotiation between mining corporates and Indigenous peoples to achieve meaningful participation in the form that it was intended under international accords. While recognising the different contextual circumstance of Indigenous peoples around the world, this paper illustrates a pathway towards meaningful participation that takes into account economic, socio-cultural and environmental variables.
A new formulation and analysis of a collapsing bubble with different content in a liquid induced during acoustic cavitation
Authors: Alhelfi Ali , Sunden Bengt Ake 
Published: August 2016

Purpose
– The purpose of this paper is to present numerical investigation of the gas/vapor bubble dynamics under the influence of an ultrasonic field to give a more comprehensive understanding of the phenomenon and present new results

Design/methodology/approach
– In order to formulate the mathematical model, a set of governing equations for the gas inside the bubble and the liquid surrounding it are used. All hydrodynamics forces acting on the bubble are considered in the typical solution. The systems of equations required to be solved consist of ordinary and partial differential equations, which are both nonlinear and time dependent equations. A fourth order Runge-Kutta method is applied to solve the ordinary differential equations. On the other hand, the finite difference method is employed to solve the partial differential equations and a time-marching technique is applied.

Findings
– The numerical model which is developed in the current study permits a correct prediction of the bubble behavior and its characteristics in an acoustic field generated at this occasion.

Originality/value
– Previous studies considering numerical simulations of an acoustic bubble were performed based on the polytropic approximation or pressure uniformity models of the contents inside the bubble. In this study, an enhanced numerical model is developed to study the acoustic cavitation phenomenon and the enhancement concerns taking into account both the pressure and temperature gradients inside the bubble as well as heat transfer through the bubble surface into account which is very important to obtain the temperature of the liquid surrounding the bubble surface.
Double MRT thermal lattice Boltzmann method for simulating natural convection of low Prandtl number fluids
Authors: Li Zheng , Yang Mo , Zhang Yuwen 
Published: August 2016

Purpose– The purpose of this paper is to test an efficiency algorithm based on lattice Boltzmann method (LBM) and using it to analyze two-dimensional natural convection with low Prandtl number.Design/methodology/approach– Steady state or oscillatory results are obtained using double multiple-relaxation-time thermal LBM. The velocity and temperature fields are solved using D2Q9 and D2Q5 models, respectively.Findings– With different Rayleigh number, the tested natural convection can either achieve to steady state or oscillatory. With fixed Rayleigh number, lower Prandtl number leads to a weaker convection effect, longer oscillation period and higher oscillation amplitude for the cases reaching oscillatory solutions. At fixed Prandtl number, higher Rayleigh number leads to a more notable convection effect and longer oscillation period.Originality/value– Double multiple-relaxation-time thermal LBM is applied to simulate the low Prandtl number (0.001-0.01) fluid natural convection. Rayleigh number and Prandtl number effects are also investigated when the natural convection results oscillate.
Influences of fuel concentration, fuel volume, initial temperature, and initial pressure on flame propagation and flameproof distance of methane-air deflagrations
Authors: Jiang Bingyou , Liu Zegong , Shi Shulei , Cai Feng , Liu Jian , Tang Mingyun , Lin Baiquan 
Published: August 2016

Purpose
– The purpose of this paper is to understand a flameproof distance necessary to avoid the flame harms to underground personnel which may have great significance to the safety of underground personnel and the disaster relief of gas explosions in coal mines.

Design/methodology/approach
– Through a roadway with a length of 100 m and a cross-section area of 80 mm×80 mm, the flame propagation of premixed methane-air deflagrations were simulated by using AutoReaGas software for various fuel concentrations (7, 8, 9.5, 11, and 14 percent), fuel volumes (0.0128, 0.0384, 0.064, and 0.0896 m3), initial temperatures (248, 268, 288, 308, and 328 K), and initial pressures (20, 60, 101.3, 150, and 200 kPa).

Findings
– The maximum combustion rate for each point follows a changing trend of increasing and decreasing with the distance increasing from the ignition source, and it increases with the fuel volume increasing or the initial pressure increasing, and decreases with the initial temperature increasing. However, increasing the initial temperature increases the flame arrival time for each point. The flameproof distance follows a changing trend of increasing and decreasing with the fuel concentration increasing, and it linearly increases with the fuel volume increasing or the initial temperature increasing. However, the flameproof distances are all 17 m for various initial pressures.

Originality/value
– Increasing initial temperature increases flame arrival time for each test point. Flameproof distance increases and then decreases with fuel concentration increasing. Increasing fuel volume or initial temperature linearly increases flameproof distance. Initial pressure has little impact on the flameproof distance.
Study on reconstruction and prediction methods of pressure field on blade surfaces for oil-filling process in a hydrodynamic retarder
Authors: Mu Hongbin , Wei Wei , Untaroiu Alexandrina , Yan Qingdong 
Published: August 2016

Purpose
– Traditional three-dimensional numerical methods require a long time for transient computational fluid dynamics simulation on oil-filling process of hydrodynamic braking. The purpose of this paper is to investigate reconstruction and prediction methods for the pressure field on blade surfaces to explore an accurate and rapid numerical method to solve transient internal flow in a hydrodynamic retarder.

Design/methodology/approach
– Dynamic braking performance for the oil-filling process was simulated and validated using experimental results. With the proper orthogonal decomposition (POD) method, the dominant modes of transient pressure distribution on blades were extracted using their spatio-temporal structural features from the knowledge of computed flow data. Pressure field on blades was reconstructed. Based on the approximate model (AM), transient pressure field on blades was predicted in combination with POD. The causes of reconstruction and prediction error were, respectively, analyzed.

Findings
– Results show that reconstruction with only a few dominant POD modes could represent all flow samples with high accuracy. POD method demonstrates an efficient simplification for accurate prediction of the instantaneous variation of pressure field in a hydrodynamic retarder, especially at the stage of high oil-filling rate.

Originality/value
– The paper presents a novel numerical method, which combines POD and AM approaches for rapid and accurate prediction of braking characteristics during the oil-filling period, based on the knowledge of computed flow data.
Managing healthcare information: analyzing trust
Authors: Söderström Eva , Eriksson Nomie , Åhlfeldt Rose-Mharie 
Published: August 2016

Purpose
– The purpose of this paper is to analyze two case studies with a trust matrix tool, to identify trust issues related to electronic health records.

Design/methodology/approach
– A qualitative research approach is applied using two case studies. The data analysis of these studies generated a problem list, which was mapped to a trust matrix.

Findings
– Results demonstrate flaws in current practices and point to achieving balance between organizational, person and technology trust perspectives. The analysis revealed three challenge areas, to: achieve higher trust in patient-focussed healthcare; improve communication between patients and healthcare professionals; and establish clear terminology. By taking trust into account, a more holistic perspective on healthcare can be achieved, where trust can be obtained and optimized.

Research limitations/implications
– A trust matrix is tested and shown to identify trust problems on different levels and relating to trusting beliefs. Future research should elaborate and more fully address issues within three identified challenge areas.

Practical implications
– The trust matrix’s usefulness as a tool for organizations to analyze trust problems and issues is demonstrated.

Originality/value
– Healthcare trust issues are captured to a greater extent and from previously unchartered perspectives.
Improved bat algorithm for structural reliability assessment: application and challenges
Authors: Chakri Asma , Khelif Rabia , Benouaret Mohamed 
Published: August 2016

Purpose– The first order reliability method requires optimization algorithms to find the minimum distance from the origin to the limit state surface in the normal space. The purpose of this paper is to develop an improved version of the new metaheuristic algorithm inspired from echolocation behaviour of bats, namely, the bat algorithm (BA) dedicated to perform structural reliability analysis.Design/methodology/approach– Modifications have been embedded to the standard BA to enhance its efficiency, robustness and reliability. In addition, a new adaptive penalty equation dedicated to solve the problem of the determination of the reliability index and a proposition on the limit state formulation are presented.Findings– The comparisons between the improved bat algorithm (iBA) presented in this paper and other standard algorithms on benchmark functions show that the iBA is highly efficient, and the application to structural reliability problems such as the reliability analysis of overhead crane girder proves that results obtained with iBA are highly reliable.Originality/value– A new iBA and an adaptive penalty equation for handling equality constraint are developed to determine the reliability index. In addition, the low computing time and the ease implementation of this method present great advantages from the engineering viewpoint.
Real‐time PCR detection of Didemnum perlucidum (Monniot, 1983) and Didemnum vexillum (Kott, 2002) in an applied routine marine biosecurity context
Authors: Simpson Tiffany J. S. , Dias P. Joana , Snow Michael , Muñoz Julieta , Berry Tina 
Published: August 2016

AbstractPrevention and early detection are well recognized as the best strategies for minimizing the risks posed by nonindigenous species (NIS) that have the potential to become marine pests. Central to this is the ability to rapidly and accurately identify the presence of NIS, often from complex environmental samples like biofouling and ballast water. Molecular tools have been increasingly applied to assist with the identification of NIS and can prove particularly useful for taxonomically difficult groups like ascidians. In this study, we have developed real‐time PCR assays suited to the specific identification of the ascidians Didemnum perlucidum and Didemnum vexillum. Despite being recognized as important global pests, this is the first time specific molecular detection methods have been developed that can support the early identification and detection of these species from a broad range of environmental sample types. These fast, robust and high‐throughput assays represent powerful tools for routine marine biosecurity surveillance, as detection and confirmation of the early presence of species could assist in the timely establishment of emergency responses and control strategies. This study applied the developed assays to confirm the ability to detect Didemnid eDNA in water samples. While previous work has focused on detection of marine larvae from water samples, the development of real‐time PCR assays specifically aimed at detecting eDNA of sessile invertebrate species in the marine environment represents a world first and a significant step forwards in applied marine biosecurity surveillance. Demonstrated success in the detection of D. perlucidum eDNA from water samples at sites where it could not be visually identified suggests value in incorporating such assays into biosecurity survey designs targeting Didemnid species.
Whether heart blocks post perimembranous ventricular septal defect device closure remain threatening: how could Chinese experiences impact the world?
Authors: Li Yifei , Zhou Kaiyu , Hua Yimin 
Published: August 2016

AbstractTranscatheter closure has become one of the alternations of surgical treatment since 1988. However, cAVB occurred as a threatening incidence of 6.8% after Amplatzer VSD Occluder closure, which was quite higher than the incidence of 1% to 2% post‐surgical closure, which leaded this kind of technique, was not approved by FDA. In this commentary, we reviewed the publications of cAVB following the device closure, and summarized current data of Modified Amplatzer‐type Occluder during long‐term follow‐up, especially introduced the experiences from China, where this kind of treatment became a routine procedure for VSD children. Moreover, we carried our visualized analysis based on scientific literatures using CiteSpace to draw knowledge burst mapping, which revealed the development procedure on this interested topics, and demonstrated the role of China's works to make contributions in the field, and figured out the limitation of our researches, which supplied a basic understanding on why we could not impact the world. Finally, it concluded that transcatheter closure of pmVSD with Modified Amplatzer‐type Occluder would be safe and efficient with low incidence of well controlled complications, but it failed to spread our experiences in a more scientific way. And, we hope this kind of therapy could be accepted in a wider region of the world with the increasing evidence from China.
Lower and reduced expression of EphA4 is associated with advanced TNM stage, lymph node metastasis, and poor survival in breast carcinoma
Authors: Sun Yuejun , Qian Jianzhong , Lu Min , Xu Hongming 
Published: August 2016

AbstractThe expression of EphA4 has been well documented in the development of nerve and in certain types of human cancer. Few studies of EphA4, however, have focused on breast carcinoma. In this study, a set of breast carcinomas was subjected to immunohistochemical staining. In normal luminal cells, EphA4 was weakly detected in 11 (14.3 %), moderately detected in 15 (19.5 %) and highly detected in 51 out of 77 (66.2 %) samples, while in breast carcinoma cells, EphA4 was weakly detected in 42 (54.5 %), moderately detected in 19 (24.7 %) and highly detected in 16 out of 77 (20.8 %) samples (P < 0.001). The expression of EphA4 protein was significantly reduced in 68.8 % of breast carcinoma samples comparing with normal cells. The expression of EphA4 was significantly associated with tumor grade (P = 0.003), TNM stage (P = 0.034), lymph node metastasis (P = 0.034) and Ki‐67 (P < 0.001). No significant relationship was found between the expression of EphA4 and age, molecular subtypes, and HER2 status. Survival analysis showed that significant association of low expression of EphA4 in tumor cells with short overall survival (P = 0.048) and disease‐free survival (P = 0.051). Our data show that EphA4 was reduced in breast carcinoma, which is associated with high grade, advanced TNM stage, lymph node metastasis, and poor outcome of patients.
INVESTOR'S SENTIMENT IN MULTI-AGENT MODEL OF THE CONTINUOUS DOUBLE AUCTION
Authors: LYKOV ALEXANDER , MUZYCHKA STEPAN , VANINSKY KIRILL 
Published: August 2016

We introduce and treat rigorously a new multi-agent model of the continuous double auction or in other words the order book (OB). It is designed to explain collective behavior of the market when new information affecting the market arrives. The novel feature of the model is two additional slow changing parameters, the so-called sentiment functions. These sentiment functions measure the conception of the fair price of two groups of investors, namely, bulls and bears. Our model specifies differential equations for the time evolution of sentiment functions and constitutes a nonlinear Markov process which exhibits long-term correlations. We explain the intuition behind equations for sentiment functions and present numerical simulations which show that the behavior of our model is similar to the behavior of the real market. We also obtain a diffusion limit of the model, the Ornstein–Uhlenbeck type process with variable volatility. The volatility is proportional to the difference of opinions of bulls and bears about the fair price of a security.