bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low fetal hemoglobin percentage is associated with silent brain lesions in adults with homozygous sickle cell disease
Authors: Calvet David , Tuilier Titien , Mélé Nicolas , Turc Guillaume , Habibi Anoosha , Abdallah Nassim Ait , Majhadi Loubna , Hemery François , Edjlali Myriam , Galacteros Frédéric , Bartolucci Pablo 
Published: December 2017

Key PointsLow %HbF is independently associated with silent WMCs on brain imaging in adults with SCD. Our results highlight the potential use of therapeutic strategies inducing HbF expression in SCD patients with silent white matter changes.
Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress
Authors: Zhao Dan , Xu Xulin , Pan Linna , Zhu Wei , Fu Xiaopei , Guo Lianjun , Lu Qing , Wang Jian 
Published: December 2017

Abstract
Background
It has been shown that chronic stress-induced depression is associated with exaggerated inflammatory response in the brain. Alpha7 nicotinic acetylcholine receptors (α7nAChRs) regulate the cholinergic anti-inflammatory pathway, but the role of cholinergic signaling and α7nAChR in chronic stress has not yet been examined.

Methods
In this study, we used a well-documented model of depression in which mice were exposed to 6 h of restraint stress for 21 consecutive days. Components of cholinergic signaling and TLR4 signaling were analyzed in the hippocampus. The main targets of neuroinflammation and neuronal damage were also evaluated after a series of tests for depression-like behavior.

Results
Chronic restraint stress (CRS) induced alterations in components of central cholinergic signaling in hippocampus, including increases in choline acetyltransferase protein expression and decreases in nuclear STAT3 signaling. CRS also increased TLR4 signaling activity, interleukin-1β, and tumor necrosis factor-α expression, microglial activation, and neuronal morphologic changes. Cholinergic stimulation with the α7nAChR agonist DMXBA significantly alleviated CRS-induced depressive-like behavior, neuroinflammation, and neuronal damage, but these effects were abolished by the selective α7nAChR antagonist α-bungarotoxin. Furthermore, activation of α7nAChRs restored the central cholinergic signaling function, inhibited TLR4-mediated inflammatory signaling and microglial activity, and increased the number of regulatory T cells in the hippocampus.

Conclusions
These findings provide evidence that α7nAChR activation mitigates CRS-induced neuroinflammation and cell death, suggesting that α7nAChRs could be a new therapeutic target for the prevention and treatment of depression.
Overview of geologic evolution and hydrocarbon generation of the Pannonian Basin
Authors: Horváth Ferenc , Dulić Ivan , Vranković Alan , Koroknai Balázs , Tóth Tamás , Wórum Géza , Kovács Gábor 
Published: December 2017

The Pannonian Basin is an intraorogenic extensional region floored by a complex system of Alpine orogenic terranes and oceanic suture zones. Its formation dates back to the beginning of the Miocene, and initial fluvial-lacustrine deposits pass into shallow to open marine strata, including a large amount of calc-alkaline volcanic materials erupted during the culmination of the synrift phase. The onset of the postrift phase occurred during the Late Miocene, when the basin became isolated and a large Pannonian lake developed. Early lacustrine marls are overlain by turbiditic sandstones and silts related to a progradational shelf slope and a delta plain sequence passing upward into alluvial plain deposits and eolian sands. A remarkable nonconformity at the top of lacustrine strata associated with a significant (4–7 my) time gap at large parts of the basin documents a neotectonic phase of activity, manifested by regional strike-slip faulting and kilometer-scale differential vertical movements, with erosion and redeposition. Subsidence and burial history modeling indicate that Middle and Late Miocene, fairly organic-rich marine and lacustrine (respectively) shales entered into the oil-generation window at about the beginning of the Pliocene in depocenters deeper than 2.5–3 km, and even reached the wet to dry gas-generation zone at depths exceeding 4–4.5 km. Migration out of these kitchens has been going on since the latest Miocene toward basement highs, where anticlines and flower structures offered adequate trapping conditions for hydrocarbons. We argue that compaction of thick sedimentary piles, in addition to neotectonic structures, has also been important in trap formation within the Pannonian Basin.
Accuracy of C-arm measurements in assessment of paediatric femoral fracture shortening
Authors: Boduch A. , Hennrikus M. , Adebayo T. , Brian J. , Hennrikus W. 
Published: December 2017

Purpose Spica casting of femoral shaft fractures is standard practice for young children. In 1983, Dr. Rang published an illustration demonstrating that radiographs can be misleading when measuring femoral fracture shortening. Today, fluoroscopy is used to determine shortening after closed reduction and spica casting. This paper aims to determine the accuracy of fluoroscopy when measuring 25 mm of shortening in a femur fracture sawbone model. Methods Magnification, elevation and angulation were evaluated using a femur fracture sawbone model with a fixed overlap of 25 mm. Two C-arm machines used in clinical practice were studied: the OEC 9900 Elite GE C-arm and the Fluoroscan InSight mini C-arm. Results The OEC 9900 Elite GE C-arm demonstrated a 1.75 × magnification. The Fluoroscan InSight mini C-arm demonstrated a 2.5 × magnification. An 11% and a 17% magnification with elevation of the femur to 8 cm occurred using the OEC 9900 Elite GE and the Fluoroscan InSight mini C-arm respectively. Changing the tube angulation from 0° to 60° resulted in a 36% and 16% change in measured femur fracture shortening on the OEC C-arm and Fluoroscan mini C-arm respectively. Conclusion C-arm images are inaccurate. When measuring 25 mm of shortening of a paediatric femur fracture, each machine has a unique amount of magnification that should be determined and accounted for in clinical practice. Elevation of the femur above the C-arm receiver and angulation of the femur further increase the inaccuracies when measuring 25 mm of fracture shortening. Images perpendicular to the fracture are most accurate.
Editor Reputation and Journal Quality: The Case of Regional Economic Association Journals
Authors: Faria João R , Mixon Franklin G , Upadhyaya Kamal P 
Published: December 2017

AbstractThis study provides a formal game that explores how editor reputation and rent seeking play a part in scholarly research that involves regional economic association journals. The game asserts that a regional economic association journal’s reputation is determined by the academic reputation of its editor, the academic reputation of the department wherein the journal is housed, and, among other things, rent seeking by scholars. Evidence from the two most prominent regional economic association journals in the United States, namelyEconomic Inquiryand theSouthern Economic Journal, generally support these aspects of the formal game.
Temperature effect on the physicochemical properties of χ-alumina interaction with CCl4
Authors: Yashnik S.A. , Salnikov A.V. , Shikina N.V. , Ischenko A.V. , Prosvirin I.P. , Litvak G.S. 
Published: December 2017

AbstractThe main characteristics in the formation of morphological, textural and acidic properties of the catalysts obtained by thermal treatment of χ-Al
Talking about Birth Control in 1877: Gender, Class, and Ideology in the Knowlton Trial
Authors: Janssen Flore 
Published: December 2017

Abstract
This article explores the debate around widening access to birth control information in the late nineteenth century through a case study of Annie Besant’s participation in the 1877 Knowlton Trial. Examining Besant’s rhetoric at the trial and in related publications, it highlights the public and performative nature of her campaign to facilitate access to birth control information for working-class married couples. With reference to the representation of issues of gender and social class and the shifting focus from the private to the public in Besant’s rhetoric, the article argues that the late nineteenth-century debate around birth control access was a middle-class debate about working-class life and experience.
“See My Heart”: Art and Alchemical Reasoning, or Character Transformation in Bryan Fuller’s Hannibal
Authors: Krawczyk-Łaskarzewska Anna 
Published: December 2017

Abstract
Works of art seem to be used more and more frequently in scripted TV shows nowadays. Most often, they constitute a symbolic point of reference, an intertextual “interlude,” or merely a convenient plot device. However, Bryan Fuller’s 2013 TV series Hannibal goes beyond the stereotypical functions of art, using it as a sort of intermediary between literary and televisual fantasies and elevating its narrative status. It can even be argued that works of art in Hannibal constitute the key element to understanding character development and transmutation in the three seasons of the show. This article focuses on the ramifications of making Sandro Botticelli’s ever-elusive Primavera a striking aspect of Hannibal’s third season. Fuller foregrounds the painting’s motif of becoming in order to repurpose the literary franchise and its cinematic offshoots. As a result, a more in-depth portrayal of its principal characters is offered, together with their unending, but ultimately incomplete alchemical cycle of purification, “fiery love,” rebirth and death: stages representing the “enlightenment and perfection” (Gillies, Botticelli’s Primavera 133) of human souls. Alongside other masterpieces displayed in the series, Primavera helps destabilise the confines of the televisual medium and of the horror genre, while at the same time demonstrating the complexity of transmedial connections and influences.
Isoperimetric problems for a nonlocal perimeter of Minkowski type
Authors: Cesaroni Annalisa , Novaga Matteo 
Published: December 2017

AbstractWe show a quantitative version of the isoperimetric inequality for a non local perimeter of Minkowski type. We also apply this result to study isoperimetric problems with repulsive interaction terms, under volume and convexity constraints.We prove existence of minimizers, and we describe their shape as the volume tends to zero or to infinity.
Characteristics of wood-silica composites influenced by the pH value of silica sols
Authors: Jiang Jun , Cao Jinzhen , Wang Wang 
Published: December 2017

Abstract
Southern pine (Pinus spp.) sapwood samples were impregnated with silica sols with known zeta potential and particle size distribution at various pH values (3, 5, 7, 9, 11 and 13) to produce wood-silica composites (WSiCs). The morphological and chemical properties of the composites were evaluated by scanning electron microscopy-energy dispersive X-ray (SEM-EDXA) and Fourier transform infrared (FTIR) spectroscopy. The overall performance of the composites was characterized by X-ray diffraction (XRD) and thermogravimetric (TG) analysis, and dynamic wettability tests, and their dimensional stability and surface hardness were also investigated as well. The pH value of the sols had a remarkable effect on the distribution of zeta potential and colloidal particle size, and on their penetration and distribution in the wood. The composites produced at pH 5 and pH 11 show relatively better impregnability and overall properties. In the first case the compatibility with the wood pH (ca. 5) is relevant, and at these pH values are the sol’s particle sizes low. Sols with pH around 13 resulted in inferior properties, such as increased water absorption, high thermal degradation and poor dimensional stability. This could be ascribed to wood degradation under high alkaline conditions. The results were discussed in view of the colloidal particle redistribution and the interaction between silica sol and wood.
Vom Sichern der Zeit und Zeigen der Geschichte. Zum Archiv als Zeitgeber des Fin de Siècle
Authors: Steglich Sina 
Published: December 2017

Zusammenfassung
Das zentrale Argument des Beitrages zielt auf eine Zeiten-Geschichte des Fin de Siècle aus der Perspektive des Archivs. Ausgehend vom Beispiel der seit dem letzten Drittel des 19. Jahrhunderts verbreiteten Archivalienausstellungen wird danach gefragt, inwiefern diese sich als Reaktion auf eine krisenhafte Zeitwahrnehmung verstehen ließen. Das Empfinden von Zeit als beschleunigter, verflüssigter oder aufgespaltener Zeit wurde um 1900 zunehmend als Problem und damit auch als zu behebende Herausforderung aufgefasst. Entsprechend galt es, die Zeit wieder zu sichern. Unter Rückgriff auf wichtige archivinterne Entwicklungen, wie die Einführung des Provenienzprinzips, die Etablierung der Archivistik als eigener Disziplin und die sich wandelnde Vorstellung von Aufgabe und Ziel nationaler Archive in Deutschland, Frankreich und Großbritannien wird herausgearbeitet, dass diese zunehmend als Voraussetzung für nationale Geschichte begriffen und konzipiert wurden. Eingebunden in einen „organologischen“ Denkmodus konnten gerade Nationalarchive dazu beitragen, die Zeitdimensionen von Vergangenheit, Gegenwart und Zukunft sinnhaft zu überbrücken und dadurch eine autorisierte Geschichte als Fundament der Gegenwart bereitzustellen. Zeit konnte dergestalt in Form von Geschichte homogenisiert gedacht und in vielfältiger Weise auch veranschaulicht werden, wofür das Beispiel der Archivmuseen symptomatisch stehen kann. Das Verständnis des Archivs als eines zentralen Zeitgebers eröffnet daher die Möglichkeit, ergänzend zum Narrativ der Standardisierung von Zeit während des Fin de Siècle auch deren Pluralisierung zu betonen.
Recovery of Phenolic Compounds and Carbohydrates from Hydro-ethanolic Extract of Zizyphus lotus Fruit using Ultrafiltration Process
Authors: Mkadmini Hammi Khaoula , Jellouli Ennigrou Dorra , Majdoub Hatem , Ksouri Riadh 
Published: December 2017

Abstract
Cross flow ultrafiltration (UF) using a cellulose membrane (cut off of 5 kDa) was employed to separate phenolic compounds from carbohydrates of hydro-ethanolic extract obtained from Zizyphus lotus fruit. The performance of the UF membrane was evaluated in terms of permeate flux, fouling index and retention values of total phenolic compounds, carbohydrates and uronic acid contents. The results showed that at VRF of 4.5, the membrane gave the highest rejections towards carbohydrates (99.89 %) and uronic acids (82.8 %) and the lowest average rejection of total phenolic compounds (3.12 %). Moreover, the permeate fraction exhibited the highest 2,2-diphenyl-1-picrylhydrazyl free radical scavenging ability and total antioxidant capacity with 0.036 mg.mL−1 and 102.145(mgGAE.g−1DM), respectively. This result is due to the presence of phenolic compounds (gallic acid, syringic acid, catechin, quercetin and kaempferol) as identified by HPLC system. Besides, a low rejection values of the UF membrane concerning these compounds were confirmed by liquid chromatography analyses.
The effect of electro-acupuncture on pro-oxidant antioxidant balance values in overweight and obese subjects: a randomized controlled trial study
Authors: Mazidi M. , Abbasi-Parizad P. , Abdi H. , Zhao B. , Rahsepar A. A. , Tavallaie S. , Parizadeh S. M. , Rezaie P. , Safariyan M. , Nematy M. , Mohammadi M. , Darbandi M. , Darbandi S. , Ghayour-Mobarhan M. , Ferns G. A. 
Published: December 2017

Abstract

Objective
To undertake a randomized controlled trial in 196 obese subjects to examine the effect of electro-acupuncture on serum pro-oxidant antioxidant balance (PAB) values.

Methods
Subjects received authentic acupuncture (cases) or sham acupuncture (controls) for 6 weeks in combination with a low-calorie diet. In the following 6 weeks, they received the low-calorie diet alone. Serum PAB was measured at baseline, and 6 and 12 weeks later.

Results
We found that serum PAB values decreased significantly in the group receiving the authentic acupuncture compared to the sham treatment (p<0.001) at week 6, and whilst serum PAB increased significantly (p<0.05) in the second phase of the study, a significant difference between two groups remained at 12 weeks (p<0.05).

Conclusions
Electro-acupuncture in combination with a low-calorie diet was more effective at reducing serum PAB values in obese subjects compared to diet alone. Further work is required to determine the mechanism by which electro-acupuncture has this effect.
Growth response to growth hormone treatment in patients with SHOX deficiency can be predicted by the Cologne prediction model
Authors: Hoyer-Kuhn Heike , Franklin Jeremy , Jones Christine , Blum Werner F. , Schoenau Eckhard 
Published: December 2017

AbstractBackgroundGrowth hormone (GH) treatment in children with short stature homeobox-containing gene (SHOX) deficiency is recognized to increase height velocity (HV) and adult height. Prediction of growth response continues to be a challenge. A comparatively accurate method is the Cologne prediction model developed in children with GH deficiency. The aim was to investigate whether this model also applies to patients with SHOX deficiency.MethodsIncluded were 48 patients with SHOX deficiency confirmed by DNA analysis and treated with 0.05 mg/kg/day of somatropin. Prediction by the Cologne model uses the following variables: relative bone age (BA) retardation, baseline insulin-like growth factor-I (IGF-I), urinary deoxypyridinoline (DPD) cross-links at 4 weeks and HV at 3 months.ResultsHV and height standard deviation scores (SDS) increased significantly during the first year of treatment. Predicted and observed HV (cm/year) showed a Pearson correlation coefficient of 0.50 (p<0.001; root-mean-square error=1.63) and for first-year change in height SDS a Pearson correlation coefficient of 0.751 (p<0.001; root-mean-square error=0.32). Poor response could be adequately predicted using SDS change, with sensitivity and specificity both above 70% for certain thresholds.Conclusions:The results demonstrate that the Cologne model can be used to predict growth response in patients with SHOX deficiency with reasonable precision in the first treatment year, comparable to prediction in patients with GH deficiency.
Allergic and non-allergic skin reactions associated with growth hormone therapy: elucidation of causative agents
Authors: Mehta Shilpa , Oza Vikash , Potashner Renee , Zamora Patricia , Raisingani Manish , Shah Bina 
Published: December 2017

AbstractBackground:Allergic and non-allergic skin reactions to recombinant human growth hormone (rhGH) are uncommon and infrequently reported. However, physicians should be aware of these potential side effects to determine whether the reactions constitute true allergies and how to proceed with growth hormone therapy. To review allergic and non-allergic skin reactions caused by rhGH and subsequent diagnostic workup and management options.Case presentation:We report the case of a 12-year-old healthy male presenting with idiopathic short stature. He developed an itchy skin rash over the chest and abdomen, 15 min after administration of the first dose of rhGH, leading us to review allergic and non-allergic skin reactions to rhGH. In our patient, an immediate skin reaction after administration of rhGH prompted a concern about a type I hypersensitivity reaction (HS) and the discontinuation of rhGH. However, after a dermatologic evaluation and observed administration of rhGH without subsequent rash, the initial eruption was likely an exacerbation of his underlying atopic dermatitis and a type I HS was felt to be unlikely. The rhGH was resumed and he has been on rhGH for the past 1 year with no recurrence of rash and with improvement in growth velocity.Conclusions:Though rare, allergic and non-allergic skin reactions are known to occur with rhGH. It is important to know if the allergic reaction was due to the growth hormone molecule or one of the preservatives. It is also important to consider a non-allergic reaction due to flare up of underlying skin disorders as in our patient.
Seasonality of blood neopterin levels in the Old Order Amish
Authors: Mohyuddin Hira , Georgiou Polymnia , Wadhawan Abhishek , Daue Melanie L. , Brenner Lisa A. , Gragnoli Claudia , Saunders Erika F.H. , Fuchs Dietmar , Lowry Christopher A. , Postolache Teodor T. 
Published: December 2017

AbstractSeasonal changes in non-human animals and seasonal affective disorder (SAD) in humans are associated with immune activation in winter relative to summer. We intended to measure seasonal variation in neopterin, a marker of cellular immunity, and its interactions with gender and seasonality of mood. We studied 320 Amish from Lancaster, PA, USA (men=128; 40%) with an average age [Standard deviation (SD)] of 56.7 (13.9) years. Blood neopterin level was measured with enzyme-linked immunosorbent assay (ELISA). Seasonality was measured with Seasonal Pattern Assessment Questionnaire (SPAQ). Statistical analysis included analysis of covariance (ANCOVAs) and multivariate linear regression. We also investigated interactions of seasonal differences in neopterin with gender, seasonality scores and estimation of SAD diagnosis. We found a significantly higher neopterin level in winter than in summer (p=0.006). There were no significant gender or seasonality interactions. Our study confirmed the hypothesized higher neopterin level in winter. A cross sectional design was our major limitation. If this finding will be replicated by longitudinal studies in multiple groups, neopterin could be used to monitor immune status across seasons in demographically diverse samples, even if heterogeneous in gender distribution, and degree of seasonality of mood.
Is face the best metaphor? / ¿Es imagen social la mejor metáfora?
Authors: Arundale Robert B. 
Published: December 2017

Abstract
Because the term “face” is used so frequently in research in language pragmatics, one overlooks the fact that it is a metaphor. This article questions whether face is the best metaphor to use in representing either the phenomena that Goffman (1955) examined, or the broad range of social practices for relating to others in using language that are evident across cultural groups. As background for questioning the viability of the metaphor of face, this article argues that the individual and social aspects of human existence form a Yin and Yang dialectic, employs this dialectic to identify three modes of explaining pragmatic phenomena, and considers both the nature of metaphors and how they afford and constrain understandings of these phenomena and conducting research on them. Using this background, the article argues that the metaphor of face has focused theory and research on the individual aspects of human existence, so that its fundamental social aspects have been overlooked and/or inadequately addressed. Exploring and employing alternatives to the metaphor of face has important benefits for theory and for research, especially if those alternative metaphors are fitted to the particular communities of practice that one is studying.
Schätzwerte in der Geschwindigkeitsüberwachung: Der Qualitätsunterschied zwischen einer Ausgleichsgeraden und der Geraden durch deren Endpunkte
Authors: Wynands Robert 
Published: December 2017

Zusammenfassung
Manche Arten von Geschwindigkeitsmessgeräten, die für die
Verkehrsüberwachung eingesetzt werden, bestimmen die Geschwindigkeit
vorbeifahrender Fahrzeuge im Wesentlichen aus der Steigung einer
Ausgleichsgeraden. Vor Gericht wird diesem Messwert gelegentlich ein
nachträglicher Schätzwert gegenübergestellt, der durch die Steigung
der Verbindungslinie zwischen erstem und letztem Messpunkt gegeben
ist. Hier wird analytisch gezeigt, um wie viel größer die
Standardabweichung des Schätzwertes im Vergleich zu der des Messwertes
ist, also um wie viel weniger verlässlich er ist. Dies gilt auch bei
Lücken in der Abfolge von Messpunkten. Der Schätzwert ist daher nicht
geeignet, einen amtlichen Messwert in Zweifel zu ziehen. An einem
Beispiel aus der Praxis wird dies illustriert.