bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advancing infection control in Australasian medical ultrasound practice
Authors: Westerway Susan Campbell , Basseal Jocelyne M 
Published: February 2017

AbstractIntroduction/AimsAustralasia is witnessing a rapidly increasing use of diagnostic medical ultrasound in clinical practice with industry statistics giving a conservative estimate of ten million scans performed annually in Australia and New Zealand. Ultrasound practice has broadened from its traditional use in radiology, obstetrics and gynaecology, vascular and cardiology specialties to embrace emergency medicine, rheumatology, midwifery, physiotherapy, paramedics and other point of care practice. With this expansion of practice comes an increase in the potential risk for ultrasound transmitted bacterial or viral infection due to suboptimal cleaning habits of transducers, cords and keyboards.Results/ConclusionThis study describes results of an Australasian survey on the disinfection and hygiene practice in medical ultrasound. Results highlighted a significant need for updated guidelines and education on infection prevention and control in medical ultrasound.
Enhancement of Antiangiogenic Efficacy of Iron(II) Complex by Selenium Substitution
Authors: Lai Haoqiang , Zhang Xiang , Feng Pengju , Xie Lina , Chen Jinjin , Chen Tianfeng 
Published: February 2017

AbstractAntiangiogenesis therapy is a proven strategy for the treatment of cancers. Herein, we demonstrate that iron(II) complexes containing 1,10‐phenanthroline(phen) derivatives were capable of suppressing angiogenesis in vitro in a dose‐dependent manner. Interestingly, the introduction of selenium into an iron(II) complex ((Fe(phenSe)3(ClO4)2 (phenSe=2‐selenoimidazole[4,5‐f]1,10‐phenanthroline)) could enhance its antiangiogenic efficacy. Mechanistic studies demonstrated that the complex potently induced endothelial cell apoptosis as evidenced by activation of caspases and PARP cleavage. The iron(II) complex activated p53‐mediated mitochondrial dysfunction as can be seen by the upregulation in the expression of p53 and proapoptotic Bcl‐2 family proteins, and downregulation in the expression of Bcl‐2 family proteins. Additionally, the complex inhibited VEGF expression and gave rise to dephosphorylated AKT, which suppressed the transmission of the mitogenic signaling pathway. Taken together, this study could provide a strategy for the rational design of high‐efficacy antivascular agents.
Maternal Antibodies to Chlamydia trachomatis and Risk of Gastroschisis
Authors: Parker Samantha E. , Werler Martha M. , Gissler Mika , Surcel Heljä‐Marja 
Published: February 2017

BackgroundGastroschisis, a birth defect of the abdominal wall, is increasing in prevalence. The largest increase in prevalence has been observed among young mothers (<20 years). The prevalence of Chlamydia trachomatis (CT) infection is highest among young women and has also been increasing over time. The objective was to investigate the association between immunoglobulin G antibodies to Chlamydia trachomatis (CT) (anti‐CT) and Chlamydial heat shock protein 60 (anti‐CHP60) during pregnancy, and risk of gastroschisis among offspring.MethodsWe conducted a nested case–control study of 292 gastroschisis cases identified from the Congenital Malformations Register and 826 live born controls matched on age and birth year within the Finnish Maternity Cohort. Early pregnancy serum samples were used to categorize women by seropositivity to anti‐CT and anti‐CHP60. Women seronegative for anti‐CT and anti‐CHP60 served as the reference. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Effect measure modification by maternal age (<25 years, ≥25 years) was also assessed.ResultsSeropositivity to anti‐CT (17.8% of cases vs. 16.0% of controls) or anti‐CHP60 (23.6% of cases vs. 22.0% of controls) was not associated with gastroschisis. Although, the OR for seropositivity to anti‐CT alone was slightly elevated (OR, 1.19; 95% CI, 0.73–1.94), specifically among young mothers (<25 years) (OR, 1.65; 95% CI, 0.81–3.37), the results were imprecise.ConclusionChlamydia infection, as measured by immunoglobulin G antibodies to CT and CHP60, is not associated with gastroschisis, however, our assays were not able to distinguish recent infection.Birth Defects Research 109:543–549, 2017.© 2017 Wiley Periodicals, Inc.
Neuroprotection of resveratrol against neurotoxicity induced by methamphetamine in mouse mesencephalic dopaminergic neurons
Authors: Sun Dong , Yue Qingwei , Guo Weihua , Li Tao , Zhang Jing , Li Guibao , Liu Zengxun , Sun Jinhao 
Published: February 2017

AbstractResveratrol is originally extracted from huzhang, a Chinese herbal medicine. Recently, resveratrol has attracted a great of attention due to its antioxidant and antiapoptotic properties. Although the neuroprotection of resveratrol on neural damages in various models has been well characterized, little is known about the role of resveratrol in methamphetamine (MA) induced neurotoxicity in mesencephalic dopaminergic neurons. Dopaminergic neurons were isolated from midbrain of mouse embryos at embryonic day 15 and cultured in the presence of MA and resveratrol. Cell viability was examined by MTT assay and the apoptosis was assessed using Hoechst33342/PI double staining. To evaluate the Oxidative damage, ROS assay was performed. Moreover, the changes of time course of intracellular free calcium concentration ([Ca2+]i) were analyzed with Fluo‐3/AM tracing. The data showed that MA induced the neurotoxicity of cultured cells in a dose‐dependent manner. Resveratrol significantly increased cellular viability and retarded cell apoptosis. Furthermore, resveratrol also attenuated MA induced ROS production and intracellular free calcium overload. Our results suggest that resveratrol protects dopaminergic neurons from MA‐induced neuronal cytotoxicity, which, at least partly, is mediated by inhibition of [Ca2+]i and oxidative stress. © 2015 BioFactors 41(4):252–260, 2015.
Selective oxidative stress and cholesterol metabolism in lipid‐metabolizing cell classes: Distinct regulatory roles for pro‐oxidants and antioxidants
Authors: Rosenblat Mira , Volkova Nina , Aviram Michael 
Published: February 2017

AbstractAtherogenesis is associated with macrophage cholesterol and oxidized lipids accumulation and foam cell formation. However, two other major lipid‐metabolizing cell classes, namely intestinal and liver cells, are also associated with atherogenesis. This study demonstrates that manipulations of cellular oxidative stress (by fatty acids, glucose, low‐density lipoprotein, angiotensin II, polyphenolic antioxidants, or the glutathione/paraoxonase 1 systems) have some similar, but also some different effects on cholesterol metabolism in macrophages (J774A.1) versus intestinal cells (HT‐29) versus liver cells (HuH7). Cellular oxidative stress was ≈3.5‐folds higher in both intestinal and liver cells versus macrophages. In intestinal cells or liver cells versus macrophages, the cholesterol biosynthesis rate was increased by 9‐ or 15‐fold, respectively. In both macrophages and intestinal cells C‐18:1 and C‐18:2 but not C‐18:0, fatty acids significantly increased oxidative stress, whereas in liver cells oxidative stress was significantly decreased by all three fatty acids. In liver cells, trans C‐18:1 versus cis C‐18:1, unlike intestinal cells or macrophages, significantly increased cellular oxidative stress and cellular cholesterol biosynthesis rate. Pomegranate juice (PJ), red wine, or their phenolics gallic acids or quercetin significantly reduced cellular oxidation mostly in macrophages. Recombinant PON1 significantly decreased macrophage (but not the other cells) oxidative stress by ≈30%. We conclude that cellular atherogenesis research should look at atherogenicity, not only in macrophages but also in intestinal and liver cells, to advance our understanding of the complicated mechanisms behind atherogenesis. © 2015 BioFactors, 41(4):273–288, 2015
Schisandrin B induces an Nrf2‐mediated thioredoxin expression and suppresses the activation of inflammasome in vitro and in vivo
Authors: Leong Pou Kuan , Ko Kam Ming 
Published: February 2017

AbstractReactive oxygen species (ROS)‐mediated activation of inflammasome is involved in the development of a wide spectrum of diseases. We aimed to investigate whether (−)schisandrin B [(−)Sch B], a phytochemical that can induce cellular antioxidant response, can suppress the inflammasome activation. Results showed that (−)Sch B can induce an nuclear factor erythroid 2‐related factor 2‐driven thioredoxin expression in primary peritoneal macrophages and cultured RAW264.7 macrophages. A 4‐h priming of peritoneal macrophages with LPS followed by a 30‐min incubation with ATP caused the activation of caspase 1 and the release of IL‐1β, indicative of inflammasome activation. Although LPS/ATP did not activate inflammasome in RAW264.7 macrophages, it caused the ROS‐dependent c‐Jun N‐terminal kinase1/2 (JNK1/2) activation and an associated lactate dehydrogenase (LDH) release in RAW264.7 macrophages, an indication of cytotoxicity. (−)Sch B suppressed the LPS/ATP‐induced activation of caspase 1 and release of IL‐1β in peritoneal macrophages. (−)Sch B also attenuated the LPS/ATP‐induced ROS production, JNK1/2 activation and LDH release in RAW264.7 macrophages. The ability of (−)Sch B to suppress LPS/ATP‐mediated inflammation in vitro was further confirmed by an animal study, in which schisandrin B treatment (2 mmol/kg p.o.) ameliorated the Imject Alum‐induced peritonitis, as indicated by suppressions of caspase1 activation and plasma IL‐1β level. The ensemble of results suggests that (−)Sch B may offer a promising prospect for preventing the inflammasome‐mediated disorders. © 2015 BioFactors, 41(5):314–323, 2015
Interactions of several genetic polymorphisms and alcohol consumption on blood pressure levels
Authors: Yin Rui‐Xing , Aung Lynn Htet Htet , Long Xing‐Jiang , Yan Ting‐Ting , Cao Xiao‐Li , Huang Feng , Wu Jin‐Zhen , Yang De‐Zhai , Lin Wei‐Xiong , Pan Shang‐Ling 
Published: February 2017

AbstractThis study aimed to detect the interactions of several single nucleotide polymorphisms (SNPs) and alcohol consumption on blood pressure levels. Genotypes of 10 SNPs in the ATP‐binding cassette transporter A1 (ABCA‐1), acyl‐CoA:cholesterol acyltransferase‐1 (ACAT‐1), low density lipoprotein receptor (LDLR), hepatic lipase gene (LIPC), endothelial lipase gene (LIPG), methylenetetrahydrofolate reductase (MTHFR), the E3 ubiquitin ligase myosin regulatory light chain‐interacting protein (MYLIP), proprotein convertase subtilisin‐like kexin type 9 (PCSK9), peroxisome proliferator‐activated receptor delta (PPARD), and Scavenger receptor class B type 1 (SCARB1) genes were determined in 616 nondrinkers and 608 drinkers. The genotypic frequencies of LDLR rs5925, LIPC rs2070895, MTHFR rs1801133, and MYLIP rs3757354 SNPs were significantly different between nondrinkers and drinkers. The levels of systolic blood pressure (ABCA‐1 rs2066715 and rs2070895), diastolic blood pressure (rs2070895), and pulse pressure (PP) (rs2066715, ACAT‐1 rs1044925, and rs1801133) in nondrinkers, and systolic blood pressure (rs1044925 and SCARB1 rs5888), diastolic blood pressure (rs1044925 and LIPG rs2000813), and PP (PCSK9 rs505151 and rs5888) in drinkers were different among the genotypes (P < 0.005–0.001). The interactions of several SNPs and alcohol consumption on systolic blood pressure (rs2066715, rs1044925, rs5925, rs2070895, rs1801133, rs3757354, PPARD rs2016520, and rs5888), diastolic blood pressure (rs2066715, rs1044925, rs5925, rs2000813, rs3757354, and rs2016520), and PP (rs1044925, rs2070895, rs1801133, rs3757354, rs505151, and rs5888) were observed (P < 0.005–0.001). The differences in blood pressure levels between the nondrinkers and drinkers might be partially attributed to the interactions of these SNPs and alcohol consumption. © 2015 BioFactors, 41(5):339–351, 2015
Disease chemopreventive effects and molecular mechanisms of hydroxylated polymethoxyflavones
Authors: Lai Ching‐Shu , Wu Jia‐Ching , Ho Chi‐Tang , Pan Min‐Hsiung 
Published: February 2017

AbstractRecent increasing attention in research of polymethoxyflavones (PMFs) from Citrus genus because of their wide range of biological properties has been reported in various studies. Hydroxylated PMFs are unique flavones and recognized as the methoxy group of PMFs that is substituted for hydroxyl one. Hydroxylated PMFs are naturally existed in citrus peel and other plants as well as occurred as metabolites of their PMFs counterparts. Several in vitro and in vivo studies have documented the chemopreventive effects of hydroxylated PMFs including anti‐cancer, anti‐inflammation, anti‐atherosclerosis, and neuroprotection. They function to regulate cell death, proliferation, differentiation, repair, and metabolism through acting on modulation of signaling cascade, gene transcription, and protein function and enzyme activity. The mechanisms of action of hydroxylated PMFs in disease chemoprevention depend on their structure, the number, and position of hydroxyl group. Although the efficacy of hydroxylated PMFs in chemoprevention and the oral bioavailability requires further investigation, they still provide great promise for improving human health. This review highlights the recent published data of hydroxylated PMFs with chemopreventive potential and the underlying mechanism involved. © 2015 BioFactors, 41(5):301–313, 2015.
A comparative study of myocardial molecular phenotypes of two tfr2β null mice: Role in ischemia/reperfusion
Authors: Boero Martina , Pagliaro Pasquale , Tullio Francesca , Pellegrino Rosa M. , Palmieri Antonietta , Ferbo Ludovica , Saglio Giuseppe , De Gobbi Marco , Penna Claudia , Roetto Antonella 
Published: February 2017

AbstractTransferrin receptor 2 (Tfr2) is an iron‐modulator transcribed in two isoforms, Tfr2α and Tfr2β. The latter is expressed in the heart. We obtained two mouse models with silencing of Tfr2β: one with a normal systemic iron amount (SIA), i.e., Tfr2‐KI, and the other, i.e., LCKO‐KI, with high SIA due to hepatic Tfr2α silencing. We aimed to assess whether Tfr2β might play a role in myocardial injury and whether Tfr2β silencing might modify proteins of iron metabolism, antioxidant, apoptotic, and survival enzyme activities in the heart undergoing ischemia/reperfusion (I/R).Isolated hearts of wild‐type (WT) and Tfr2‐null mice were studied before or after an I/R protocol, and proteins/RNA analyzed by Western blot and/or quantitative PCR.Tfr2β increased in WT hearts subject to I/R, and both Tfr2β null mice hearts were protected against I/R injury (about 40% smaller infarct‐size compared to WT hearts). RISK kinases (ERK1/2‐AKT‐PKCε) were found up‐regulated after I/R in Tfr2‐KI, whereas SAFE enzyme (Stat3) and GSK3β resulted phosphorylated during I/R in LCKO‐KI hearts. While HO‐1 and HIF‐2a were high in both Tfr2β‐null mice, Catalase, and proapoptotic factors were upregulated only in LCKO‐KI. Finally, Tfr2‐KI hearts presented an increased Ferritin‐H and a decreased Ferroportin1, whereas LCKO‐KI hearts displayed an upregulation of Ferritin‐L chain and DMT1/Hamp‐RNA.In conclusion, Tfr2β isoform is involved in cardiac iron metabolism and its silencing leads to a protected phenotype (antioxidants, RISK, and/or SAFE upregulation) against I/R challenging. Iron‐dependent signals involved in cardioprotection seem to be positively affected by Tfr2β downregulation and subsequent Ferritins upregulation. © 2015 BioFactors, 41(5):360–371, 2015
Less increase of copeptin and MR‐proADM due to intervention with selenium and coenzyme Q10 combined: Results from a 4‐year prospective randomized double‐blind placebo‐controlled trial among elderly Swedish citizens
Authors: Alehagen Urban , Aaseth Jan , Johansson Peter 
Published: February 2017

AbstractIntervention with selenium and coenzyme Q10 have recently been found to reduce mortality and increase cardiac function. The mechanisms behind these effects are unclear. As selenium and coenzyme Q10 is involved in the anti‐oxidative defence, the present study aimed to evaluate effects of selenium and coenzyme Q10 on copeptin and adrenomedullin as oxidative stress biomarkers. Therefore 437 elderly individuals were included and given intervention for 4 years. Clinical examination and blood samples were undertaken at start and after 18 and 48 months. Evaluations of copeptin and MR‐proADM changes were performed using repeated measures of variance. Cardiovascular mortality was evaluated using a 10‐year‐period of follow‐up, and presented in Kaplan‐Meier plots. A significant increase in copeptin level could be seen in the placebo group during the intervention period (from 9.4 pmol/L to 15.3 pmol/L), compared to the active treatment group. The difference between the groups was confirmed in the repeated measurement of variance analyses (P = 0.031) with less copeptin increase in the active treatment group. Furthermore, active treatment appeared to protect against cardiovascular death both in those with high and with low copeptin levels at inclusion. Less increase of MR‐proADM could also be seen during the intervention in the active treatment group compared to controls (P=0.026). Both in those having an MR‐proADM level above or below median level, significantly less cardiovascular mortality could be seen in the active treatment group (P=0.0001, and P=0.04 respectively). In conclusion supplementation with selenium and coenzyme Q10 during four years resulted in less concentration of both copeptin and MR‐proADM. A cardioprotective effect of the supplementation was registered, irrespective of the initial levels of these biomarkers, and this protection was recognized also after 10 years of observation. © 2015 BioFactors, 41(6):443–452, 2015
Self‐efficacy or perceived behavioural control: Which influences consumers' physical activity and healthful eating behaviour maintenance?
Authors: Parkinson Joy , David Patricia , Rundle‐Thiele Sharyn 
Published: February 2017

AbstractThis research investigated the role of a commercial program, Michelle Bridges 12 Week Body Transformation (MB12WBT), that uses a variety of tools including social support to influence weight management behaviours such as exercising and eating healthfully. The need for research into weight management remains current given obesity rates have continued to increase in recent decades. Weight management is a complex behaviour that for many consumers involves barriers that influence their commitment to continue exercising and eating healthily. The Theory of Planned Behaviour is frequently used to explain, and to a lesser extent predict, behaviours such as physical activity and healthy eating; however, there is much debate as to whether a perceived behavioural control variable or self‐efficacy is the best predictor of behaviour. Structural equation modelling was used to analyse data from a sample of 724 respondents who answered a baseline and three month follow‐up survey. The analysis revealed self‐efficacy and perceived behavioural control were two distinct constructs. Self‐efficacy was a better predictor of behaviour than perceived behavioural control variables as suggested in the original Theory of Planned Behaviour. Furthermore, self‐efficacy had a significant impact on exercising and eating healthfully behaviour. The findings and implications for both behaviour change theory and practice are discussed.
Bleomycin‐induced flagellate hyperpigmentation
Authors: Larson Krista N. , Gagnon Amy L. , Wilson Barbara B. 
Published: February 2017

Key Clinical MessageA 27‐year old male with Hodgkin's lymphoma was treated with combined chemotherapy that included bleomycin. He presented with pruritic erythematous, edematous linear lesions and was diagnosed to have flagellate hyperpigmentation, a rare side effect of bleomycin chemotherapy.
Neonatal mucolipidosis type II alpha/beta due to compound heterozygosity for a known and novel GNPTAB mutation, and a concomitant heterozygous change in SERPINF1 inherited from the mother
Authors: Wood Kirsten A. , Zambrano Regina M. , Cheek Bradley J. , Arcement Christopher , Haymon Marie , Steinkampf Jessica , Sampath Srirangan , Hyland James C. , Lacassie Yves 
Published: February 2017

Key Clinical MessageWe report on a newborn with IUGR, rhizomelic dwarfism, and suspected chondrodysplasia punctata. At birth, OI was suspected; however, a skeletal survey suggested ML II alpha/beta. Sequencing revealed compound heterozygosity for a reported pathogenic and novel but expected pathogenic GNPTAB variant. Molecular testing for autosomal recessive OI identified a SERPINF1 variant.
Correlation between Microstructure Evolution of a Well‐Defined Cubic Palladium Catalyst and Selectivity during Acetylene Hydrogenation
Authors: Niu Yiming , Zhang Bingsen , Luo Jingjie , Zhang Liyun , Chen Cheng‐Meng , Su Dang Sheng 
Published: February 2017

AbstractThe varied surface structures of a Pd catalyst showed different catalytic performances in the partial hydrogenation of acetylene. The exposed Pd (1 0 0) facet is considered to be the most selective of all other facets for the formation of ethylene, but it is unstable and the fine structure needs to be revealed during the reaction. Herein, the evolution of the surface structure of cubic Pd nanoparticles, which are all bound with (1 0 0) facets, was studied by transmission electron microscopy in the partial hydrogenation of acetylene. Furthermore, the relation between the varying surface structure and the activity/selectivity was correlated. The (1 0 0) facets of Pd were transformed into stepped facets during the reaction, derived by adsorption/desorption of the reactants and energy compensation, which was the main reason for the decrease in the selectivity towards ethylene.
Catalytic Formation of Silicon–Heteroatom (N, P, O, S) Bonds
Authors: Kuciński Krzysztof , Hreczycho Grzegorz 
Published: February 2017

AbstractSilicon and its compounds with other heteroatoms have received considerable attention, particularly because of their applicative ability. Silicon forms a large number of compounds with other p‐block elements (e.g., C, N, S, O, F, Cl, and others). All of them affect practical chemistry to some extent and are characterized by unique properties. This article highlights recent developments and covers the literature from the last 10 years. It is mainly focused on catalytic methods for silicon–nitrogen, silicon–phosphorus, silicon–oxygen, and silicon–sulfur bond formation. The scope and applications of these practical compounds will also be discussed.
Pd Nanoparticles Decorated on Hypercrosslinked Microporous Polymer: A Highly Efficient Catalyst for the Formylation of Amines through Carbon Dioxide Fixation
Authors: Molla Rostam Ali , Bhanja Piyali , Ghosh Kajari , Islam Sk Safikul , Bhaumik Asim , Islam Sk Manirul 
Published: February 2017

AbstractCO2 fixation reaction is one of the most challenging chemical transformations not only in the context of environmental remediation but also for effective utilization of abundant carbon sources in nature. Here, we have stabilized palladium nanoparticles (NPs) at the surfaces of a hypercrosslinked porous polymer bearing carbazole and α,α′‐dibromo‐p‐xylene monomeric units to obtain a Pd@HMP‐1 nanocatalyst. The material has been thoroughly characterized by powder XRD, high‐resolution (HR)‐TEM, field‐emission (FE)‐SEM, Brunauer–Emmett–Teller (BET), thermogravimetric (TGA), and FTIR analysis. Pd@HMP‐1 showed excellent catalytic activity towards formylation of amines by carbon dioxide fixation under mild reaction conditions. The high surface area and nitrogen‐rich porous surface make the polymer a suitable support for the palladium nanoparticles and endow it with high recycling efficiency in this CO2 fixation reaction.