bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extracellular matrix protein 1 gene (ECM1) mutations in nine Iranian families with lipoid proteinosis
Authors: Izadi Farzad , Mahjoubi Frouzandeh , Farhadi Mohammad , Kalayinia Samira , Bidmeshkipour Ali , Tavakoli Mohammad Moein , Samanian Sara 
Published: May 2016

Background & objectives:
Lipoid proteinosis (LP) is an autosomal recessive disease. Clinical characteristics of this disease are hoarse voice, scarring of the skin, brain calcifications, and eyelid papules (moniliform blepharosis). Mutations in the ECM1 gene on 1q21.2 are responsible for this disease. This study was conducted to investigate the mutation spectrum of ECM1 gene in nine Iranian families having at least one LP patient diagnosed clinically.

Methods:
The entire ECM1 gene was screened using PCR and direct sequencing in nine Iranian families with 12 suspected LP patients who were referred to the clinic, along with their parents and siblings. Thirty healthy individuals were included as controls.

Results:
In only one patient a homozygous G>A transition at nucleotide c.806 in exon 7 was detected. A G>A substitution at nucleotide 1243 in exon 8 that changes glycine (GGT) to serine (AGT) was observed in most of our patients. Furthermore, in one patient there was a change in the sequence of intron 8, the A>T transition in nucleotide 4307. In addition, in two cases (one patient and one healthy mother with affected child) there was a C (4249) deletion in intron 8.

Interpretation & conclusions:
Our results indicate that although mutation in ECM1gene is responsible for lipoid proteinosis, it is likely that this is not the only gene causing this disease and probably other genes may be involved in the pathogenesis of the LP disease.
High burden of hepatitis C & HIV co-infection among people who inject drugs in Manipur, Northeast India
Authors: Kermode Michelle , Nuken Amenla , Medhi Gajendra Kumar , Akoijam Brogen Singh , Sharma H. Umesh , Mahanta Jagadish 
Published: May 2016

Background & objectives:
It is well documented that the Northeast State of Manipur in India has been dealing with the dual problems of injecting drug use and HIV for the last two decades, but the hepatitis C problem has not been so well characterized. The aim of this study was to assess the prevalence of hepatitis C virus (HCV) infection and HCV/HIV co-infection among people who inject drugs (PWID) in Manipur, and identify factors associated with infection.

Methods:
Data were obtained from the Integrated Behavioural and Biological Assessment (2009-2010), a cross-sectional survey among 821 male PWID in two districts of Manipur (Churachandpur and Bishnupur). Information about drug use, sexual and injecting risk behaviours, and exposure to interventions was obtained, and biological specimens tested for HIV and HCV. Logistic regression analyses identified factors associated with HCV infection and HCV/HIV co-infection.

Results:
HCV prevalence was 74 per cent (91% Churachandpur, 56% Bishnupur), and HCV/HIV co-infection was 29 per cent (38% Churachandpur, 21% Bishnupur). Among the 31 per cent of HIV positive PWID, 95 per cent were co-infected. HCV infection was associated with district, longer duration of injecting, injecting at least once daily, generally injecting with a used needle and syringe, and having had an HIV test. HCV/HIV co-infection was associated with district, older age, being employed, being widowed/divorced, longer duration of injecting, and feeling at risk of HIV infection.

Interpretation & conclusions:
The HCV/HIV co-infection among PWID in Manipur was very high, highlighting the urgent need for effective prevention, diagnosis and treatment.
All-inprijs ambtshalve getoetst
Authors: Spanjaard J.H.M. 
Published: May 2016

All-inprijs ambtshalve getoetst
De Hoge Raad heeft in zijn arrest van 12 februari 2016 een nieuw hoofdstuk toegevoegd aan de sage over de ‘gratis’ mobiele telefoon. Op 13 juli 2014 maakte de Hoge Raad in het arrest Lindorff/Statia duidelijk dat de verstrekking van een mobiel bij een telefoonabonnement niet gratis is, maar als koop op afbetaling c.q. consumentenkrediet moet worden beschouwd. Op 12 februari 2016 voegt de Hoge Raad toe dat ten aanzien van de koop op afbetaling c.q. het consumentenkrediet ambtshalve moet worden getoetst of de overeenkomst onredelijk bezwarend is jegens de consument. De all-in prijsbepaling is volgens de Hoge Raad een kernbeding.
Abciximab in the treatment of coronary artery disease
Authors: Jayasinghe Rohan , Maxwell Ryan , Murdoch Dale 
Published: May 2016

Antiplatelet therapy constitutes a cornerstone in the strategies aimed at the effective management of acute coronary syndrome. Abciximab is the oldest and most commonly used intravenous antiplatelet agent in this context, in particular when an invasive strategy is adopted. It is very commonly used in more unstable and high- risk patients. Trials have proven the event-free survival benefits of using abciximab in the right context. This agent also has some adverse outcomes associated with its use that the clinicians need to be well aware of and take precautions against. The comparative cost efficacy with its use too is of significance. There is a growing evidence base on the different ways abciximab is used and the benefits and risks thereof. Since the development and introduction of novel anticoagulants and more potent oral anti-platelet agents, the place of abciximab in the treatment of acute coronary syndrome today needs to be reviewed and clearly defined. This review attempts to study the cross-section of the evidence base to date on the clinical use, efficacy and risks related to the use of abciximab and spotlight the most recent guidelines published by the different global peak bodies to provide a practical overview to the clinician.
Pour une approche systémique et pragmatique de la transition écologique des systèmes agri-alimentaires
Authors: Lamine Claire , Bui Sibylle , Ollivier Guillaume 
Published: May 2016

En partant de la confrontation de trois grands cadres théoriques permettant de traiter des processus de transformation des systèmes agri-alimentaires, les théories des transitions socio-techniques, celles de la sociologie pragmatique, et celles des food regimes, cet article formule une proposition qui emprunte à ces différents cadres pour construire une approche systémique, historicisée et ancrée dans la sociologie pragmatique de ces processus. Approche systémique et historicisée, car il s’agit de saisir comment la modification dans le temps des interdépendances entre certains maillons et acteurs des systèmes agri-alimentaires conduisent à ces processus de transition. Ancrée dans la sociologie pragmatique, car nous proposons également de nous intéresser aux controverses opposant divers acteurs revendiquant une transition écologique, ainsi qu’aux processus de changement de pratiques qu’ils mettent éventuellement en oeuvre. En vue de montrer l’intérêt d’une telle proposition, nous appliquons ensuite cette proposition à trois cas d’étude : d’une part, l’analyse du processus d’institutionnalisation de l’agroécologie au Brésil et en France, et d’autre part, celle de la transition agroécologique à l’échelle d’un système agri-alimentaire territorial.
Associer les habitants à la transition écologique
Authors: Christen Guillaume , Hamman Philippe 
Published: May 2016

À l’heure où le changement climatique s’est affirmé comme un problème politique et un objet de politique publique tant au niveau global que national et local, l’article éclaire la question de la transition écologique à travers la mise en oeuvre de la transition énergétique en Alsace (France), et plus spécialement la possibilité donnée aux acteurs dits ordinaires d’y prendre part. À partir de trois cas d’étude – l’éolien citoyen dans une commune rurale, la mise en oeuvre par un bailleur social d’une action de maîtrise de l’énergie auprès d’habitants de logements sociaux à Strasbourg et l’installation de dispositifs d’énergie solaire auprès de propriétaires à Plobsheim, en couronne périurbaine de Strasbourg –, nous interrogeons la dimension participative des projets : en quoi permettent-ils (ou pas) d’associer les habitants et de concevoir des modes de gouvernance qui rendent possible une appropriation sociale des problématiques énergétiques et environnementales ?
L’articulation des identités plurielles à travers l’éducation : l’exemple de quatre écoles juives à Montréal
Authors: Hirsch Sivane 
Published: May 2016

Les écoles ethno-religieuses juives de Montréal, qui accueillent la majorité des jeunes de la communauté, jouent un rôle important dans leur socialisation au sein de la société québécoise. Dans le cadre d’une enquête dans quatre écoles primaires juives qui représentent à bien des égards la diversité au sein de la communauté, nous avons examiné la manière dont elles intègrent le curriculum québécois général dans un projet éducatif « juif » et l’environnement dans lequel il est enseigné. C’est ainsi que les élèves sont constamment invités à articuler leurs identités multiples pour devenir membres engagés d’une communauté minoritaire.
Ultraflexible and ultrathin polymeric gate insulator for 2 V organic transistor circuits
Authors: Kondo Masaya , Uemura Takafumi , Matsumoto Takafumi , Araki Teppei , Yoshimoto Shusuke , Sekitani Tsuyoshi 
Published: May 2016

Abstract
We have developed a high-yield process for fabricating organic transistors with ultraflexible and ultrathin polymeric (parylene) insulators. In a top-contact bottom-gate configuration, an oxygen plasma treatment for a Au gate surface before parylene deposition significantly improved the yield of transistors, enabling the parylene thickness to be reduced to 18 nm. Taking full advantage of the ultraflexible and ultrathin insulator, we have demonstrated 2 V ring oscillator circuits, where the yield was 97% for 360 transistors inside the area of 7 × 7 cm2. The highly reliable ultrathin insulator is useful for large-area circuits with low-voltage organic transistors.
Subnanosecond-laser-induced periodic surface structures on prescratched silicon substrate
Authors: Hongo Motoharu , Matsuo Shigeki 
Published: May 2016

Abstract
Laser-induced periodic surface structures (LIPSS) were fabricated on a prescratched silicon surface by irradiation with subnanosecond laser pulses. Low-spatial-frequency LIPSS (LSFL) were observed in the central and peripheral regions; both had a period Λ close to the laser wavelength λ, and the wavevector orientation was parallel to the electric field of the laser beam. The LSFL in the peripheral region seemed to be growing, that is, expanding in length with increasing number of pulses, into the outer regions. In addition, high-spatial-frequency LIPSS,

, were found along the scratches, and their wavevector orientation was parallel to the scratches.
Deep level traps in GaN LEDs grown by metal organic vapour phase epitaxy on an 8 inch Si(111) substrate
Authors: Nguyen Xuan Sang , Goh Xuan Long , Zhang Li , Zhang Zeng , Arehart Aaron R. , Ringel Steven A. , Fitzgerald Eugene A. , Chua Soo Jin 
Published: May 2016

Abstract
Deep level traps present in GaN LED grown on 8 in. Si substrate were revealed by deep level transient spectroscopy (DLTS). One electron trap located at E
C − 0.7 eV was revealed in the n-GaN barrier layer. Two electron traps and one hole trap were observed in the p-GaN layer. They are located at E
C − 0.60 eV, E
C − 0.79 eV and E
V + 0.70 eV. The total trap density in both the n-GaN barrier layer and the p-GaN layer of the LED is in order of 1014 cm−3, which is comparable with that found in GaN epi-layer grown on sapphire.
Pt–Ti–O gate silicon–metal–insulator–semiconductor field-effect transistor hydrogen gas sensors in harsh environments
Authors: Usagawa Toshiyuki , Ueda Kazuhiro , Nambu Akira , Yoneyama Akio , Kikuchi Yota , Watanabe Atsushi 
Published: May 2016

Abstract
The influence of radiation damages to developed hydrogen gas sensor chips from γ-rays (60Co) and/or X-rays (synchrotron radiation) is manageably avoided for sensor operations even at extremely high integral doses such as 1.8 and/or 18 MGy. Platinum–titanium–oxygen (Pt–Ti–O) gate silicon–metal–insulator–semiconductor field-effect transistor (Si-MISFET) hydrogen gas sensors can work stably as hydrogen sensors up to about 270 °C and also show environmental hardness as follows: When nitrogen-diluted 10-ppm hexamethyldisiloxane (HMDS) was exposed to the sensor FETs for 40 min at a working temperature of 115 °C, large sensing amplitude (ΔV
g) changed little within repetition errors before and after HMDS exposures. The variations of ΔV
g among relative humidity of 20 and 80% are very small within ±4.4% around 50% under 40 °C atmosphere. The Pt–Ti–O sensors have been found to show large ΔV
g of 624.4 mV with σΔV
g of 7.27 mV for nine times repeated measurements under nitrogen-diluted 1.0%-hydrogen gas, which are nearly the same values of 654.5 mV with σΔV
g of 3.77 mV under air-diluted 1.0%-hydrogen gas.
Bonding dynamics of compliant microbump during ultrasonic bonding investigated by using Si strain gauge
Authors: Iwanabe Keiichiro , Nakadozono Kenichi , Senda Yousuke , Asano Tanemasa 
Published: May 2016

Abstract
The bonding dynamics of a cone-shaped microbump during ultrasonic bonding are investigated by in situ measurements of the strain generated in a substrate using a piezoresistance strain sensor. The strain sensor is composed of a pair of p- and n-type piezoresistance gauges to extract strain components in the ultrasonic vibration along the plane parallel to the substrate surface and along the direction perpendicular to the surface. Flip-chip bonding is performed at room-temperature. The time evolution of the strain generated in the substrate according to the load-up of pressing force and application of ultrasonic vibration is clearly detected. The softening of the bump metal during the application of ultrasonic vibration is clearly observed. Results of a comparative study between the bonding of a cone-shaped microbump and that of a flat-top microbump suggest mechanical stress concentration near the top end of the cone-shaped microbump, which results in the transformation of the crystal texture of the bump from grains to fine crystallites.
Evaluation technique for plasma-induced SiOC dielectric damage by capacitance–voltage hysteresis monitoring
Authors: Nishida Kentaro , Okada Yukimasa , Takao Yoshinori , Eriguchi Koji , Ono Kouichi 
Published: May 2016

Abstract
We propose an electrical method, named capacitance–voltage (C–V) monitoring, for quantifying plasma-induced damage (PID) to interlayer dielectrics. By this method, we measure the C–V hysteresis loops to assign carrier trap sites created by PID, and simultaneously obtain the change in the dielectric constant and thickness. We optimized the bias-sweep configuration for measuring the hysteresis curves. It is found that the C–V curve shifted in the negative direction during the optimized voltage sweep from accumulation to inversion in a pseudo-metal–oxide–semiconductor (MOS) structure. This implies the appearance of net positively charged sites owing to PID, presumably near the surface of the SiOC film. We estimate the density of defects created near the surface by monitoring the obtained C–V hysteresis curve shift. Since the degradation of interlayer dielectrics affects the circuit performance, the proposed quantitative method should be used for plasma process designs.
Study on the contact resistance of various metals (Au, Ti, and Sb) on Bi–Te and Sb–Te thermoelectric films
Authors: Yong Ho , Na Sekwon , Gang Jun-Gu , Shin HaeSun , Jeon Seong-Jae , Hyun SeungMin , Lee Hoo-Jeong 
Published: May 2016

Abstract
In this study, we explore various electrode materials (Au, Ti, and Sb) for use as contact materials on Bi2Te3 and Sb2Te3 thermoelectric films. Using the transmission line method (TLM), we measured the specific resistivity of the contacts, which showed that Au has the lowest contact resistivity for both the thermoelectric films (after annealing): 2.7 × 10−10 Ω m2 for Bi2Te3 and 2.9 × 10−11 Ω m2 for Sb2Te3. The specific contact resistivity data suggest that the dominant factor for the contact properties is interface states. After annealing, the contact resistivity does not change much for the Bi2Te3 contacts while it drops greatly for the Sb2Te3 ones. Analysis of the carrier transport mechanism across the contacts discloses that changes in the carrier concentration in the thermoelectric films after annealing are responsible for the different behaviors.
Light scattering model for individual sub-100-nm particle size determination in an evanescent field
Authors: Khajornrungruang Panart , Korkmaz Sevim , Angshuman Pal , Suzuki Keisuke , Kimura Keiichi , Babu Suryadevara V. 
Published: May 2016

Abstract
In this paper, we propose an optical method for observation and determination of individual nanosized particles that adhere to an interface by applying an evanescent field. Subsequently, we developed a portable (∼350 mm in length) experimental apparatus equipped with an optical microscopy system for particle observation. The observed intensity is consistent with that calculated using a light scattering model of sub-100-nm particles in the evanescent field.
Similarities between decapod and insect neuropeptidomes
Authors: Veenstra Jan A. 
Published: May 2016

Background.Neuropeptides are important regulators of physiological processes and behavior. Although they tend to be generally well conserved, recent results using trancriptome sequencing on decapod crustaceans give the impression of significant differences between species, raising the question whether such differences are real or artefacts.Methods.The BLAST+ program was used to find short reads coding neuropeptides and neurohormons in publicly available short read archives. Such reads were then used to find similar reads in the same archives, and the DNA assembly program Trinity was employed to construct contigs encoding the neuropeptide precursors as completely as possible.Results.The seven decapod species analyzed in this fashion, the crabsEriocheir sinensis, Carcinus maenasandScylla paramamosain, the shrimpLitopenaeus vannamei, the lobsterHomarus americanus, the fresh water prawnMacrobrachium rosenbergiiand the crayfishProcambarus clarkiihad remarkably similar neuropeptidomes. Although some neuropeptide precursors could not be assembled, in many cases individual reads pertaining to the missing precursors show unambiguously that these neuropeptides are present in these species. In other cases, the tissues that express those neuropeptides were not used in the construction of the cDNA libraries. One novel neuropeptide was identified: elongated PDH (pigment dispersing hormone), a variation on PDH that has a two-amino-acid insertion in its core sequence. Hyrg is another peptide that is ubiquitously present in decapods and is likely a novel neuropeptide precursor.Discussion.Many insect species have lost one or more neuropeptide genes, but apart from elongated PDH and hyrg all other decapod neuropeptides are present in at least some insect species, and allatotropin is the only insect neuropeptide missing from decapods. This strong similarity between insect and decapod neuropeptidomes makes it possible to predict the receptors for decapod neuropeptides that have been deorphanized in insects. This includes the androgenic insulin-like peptide that seems to be homologous to drosophila insulin-like peptide 8.
Shot noise modeling of daily streamflows: A hybrid spectral‐ and time‐domain calibration approach
Authors: Morlando F. , Cimorelli L. , Cozzolino L. , Mancini G. , Pianese D. , Garofalo F. 
Published: May 2016

AbstractThe aim of this paper is to describe and evaluate a hybrid spectral‐ and time‐domain approach for the calibration of shot noise models for daily streamflow generation. The calibration approach allows the parameter estimation of a minimum‐phase rainfall/streamflow model using two steps. In the predictor step, the power spectral density of a recorded streamflow series is used to calibrate the parameters connected with the model dynamics. During the corrector step, a classic time‐domain procedure is used to calibrate the parameters connected with the average output of the model and the parameters that characterize the rainfall stochastic process. The procedure is demonstrated through its application to the daily streamflow time series associated with three Italian watersheds, and its results are then compared with those obtained by means of a time‐domain calibration method available in the literature.
On the structural limitations of recursive digital filters for base flow estimation
Authors: Su Chun‐Hsu , Costelloe Justin F. , Peterson Tim J. , Western Andrew W. 
Published: May 2016

AbstractRecursive digital filters (RDFs) are widely used for estimating base flow from streamflow hydrographs, and various forms of RDFs have been developed based on different physical models. Numerical experiments have been used to objectively evaluate their performance, but they have not been sufficiently comprehensive to assess a wide range of RDFs. This paper extends these studies to understand the limitations of a generalized RDF method as a pathway for future field calibration. Two formalisms are presented to generalize most existing RDFs, allowing systematic tuning of their complexity. The RDFs with variable complexity are evaluated collectively in a synthetic setting, using modeled daily base flow produced by Li et al. (2014) from a range of synthetic catchments simulated with HydroGeoSphere. Our evaluation reveals that there are optimal RDF complexities in reproducing base flow simulations but shows that there is an inherent physical inconsistency within the RDF construction. Even under the idealized setting where true base flow data are available to calibrate the RDFs, there is persistent disagreement between true and estimated base flow over catchments with small base flow components, low saturated hydraulic conductivity of the soil and larger surface runoff. The simplest explanation is that low base flow “signal” in the streamflow data is hard to distinguish, although more complex RDFs can improve upon the simpler Eckhardt filter at these catchments.
Detecting changes in future precipitation extremes over eight river basins in China using RegCM4 downscaling
Authors: Qin Peihua , Xie Zhenghui 
Published: May 2016

AbstractTo detect the frequency and intensity of precipitation extremes in China for the middle 21st century, simulations were conducted with the regional climate model RegCM4 forced by the global climate model GFDL_ESM2M under the middle emission scenario (RCP4.5). Compared with observed precipitation extremes for the reference period from 1982 to 2001, RegCM4 generally performed better in most river basins of China relative to GFDL. In the future period 2032–2051, more wet extremes will occur relative to the present period in most study areas, especially in southeast China while significantly less dry extremes will occur in arid and semiarid areas in northwest China. In contrast, areas in northwest China showed an increase in the trend of dry extremes (CDD) and a decrease in the trend of wet extremes (R95p and Rx5day), which might result in more drought in the future. Finally, we discuss in detail the possible reason of these processes, such as zonal wind, vertical wind, and water vapor. In the Huaihe river basin (HU), reduced south winds in summer (June–August) and a decrease of the upward vertical p velocity cause less future precipitation and might lead to changes of extreme events. We also completed correlation analysis between the precipitation extreme indices and the climate factors and found that the precipitation extremes were more sensitive to the annual and seasonal mean precipitation, total water vapor, and upward vertical wind relative to the geopotential height and 2 m temperature over most river basins in China. Perhaps the changes of some wet extremes could be verified partly through changes of annual precipitation due to their high consistence.