bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rare case of a pericardial mass: Myelosarcoma from relapsed acute monoblastic leukaemia without bone marrow involvement
Authors: Binny Simon , Tomlinson Stephen , Hammett Christopher , Dahiya Arun , Pillai Elango , Prasad Sandhir B. 
Published: October 2017

AbstractIntroductionA 67‐year‐old male presented with progressive exertional dyspnoea, night sweats and 25 kg of weight loss over 2 years. He was febrile, 38.0°C, hypotensive and tachycardiac. Pulsus paradoxus was present. His electrocardiogram showed electrical alternans. He had previously had acute myeloid leukaemia treated with three cycles of chemotherapy.ResultsThe patient was found to have a 3.6 cm pericardial effusion with features consistent with tamponade and three cardiac masses (largest 10 × 9 × 5 cm) and mediastinal lymphadenopathy. He had 825 mL of pericardial fluid drained from which cytology was consistent with extramedullary leukaemia. A bone marrow aspirate and trephine was normal.ConclusionThe findings suggested extramedullary recurrence of leukaemia in the pericardium, without bone marrow involvement.
Utilising Sodium‐Mediated Ferration for Regioselective Functionalisation of Fluoroarenes via C−H and C−F Bond Activations
Authors: Maddock Lewis C. H. , Nixon Tracy , Kennedy Alan R. , Probert Michael R. , Clegg William , Hevia Eva 
Published: October 2017

AbstractPairing iron bis(amide) Fe(HMDS)2 with Na(HMDS) to form new sodium ferrate base [(dioxane)0.5⋅NaFe(HMDS)3] (1) enables regioselective mono and di‐ferration (via direct Fe−H exchange) of a wide range of fluoroaromatic substrates under mild reaction conditions. Trapping of several ferrated intermediates has provided key insight into how synchronised Na/Fe cooperation operates in these transformations. Furthermore, using excess 1 at 80 °C switches on a remarkable cascade process inducing the collective twofold C−H/threefold C−F bond activations, where each C−H bond is transformed to a C−Fe bond whereas each C−F bond is transformed into a C−N bond.
Ruthenium(0)‐katalysierte Cycloaddition von 1,2‐Diolen, Ketolen oder Dionen durch Alkohol‐vermittelte Wasserstoffübertragung
Authors: Sato Hiroki , Turnbull Ben W. H. , Fukaya Keisuke , Krische Michael J. 
Published: October 2017

AbstractDurch die Kombination der Charakteristiken von Transferhydrierung und Carbonyladdition wurde eine neue breite Klasse von Ruthenium(0)‐katalysierten Cycloadditionen entwickelt. Wie in diesem Kurzaufsatz erläutert, können anellierte oder überbrückte bicyclische Ringsysteme redoxunabhängig in C‐C‐Kupplungs‐Wasserstofftransfer‐Reaktionen von Diolen, α‐Ketolen oder 1,2‐Dionen mit verschiedenartigen ungesättigten Reaktanten synthetisiert werden.
Ruthenium(0)‐Catalyzed Cycloaddition of 1,2‐Diols, Ketols, or Diones via Alcohol‐Mediated Hydrogen Transfer
Authors: Sato Hiroki , Turnbull Ben W. H. , Fukaya Keisuke , Krische Michael J. 
Published: October 2017

AbstractMerging the characteristics of transfer hydrogenation and carbonyl addition, a broad new class of ruthenium(0)‐catalyzed cycloadditions has been developed. As discussed in this Minireview, fused or bridged bicyclic ring systems are accessible in a redox‐independent manner in C−C bond‐forming hydrogen transfer reactions of diols, α‐ketols, or 1,2‐diones with diverse unsaturated reactants.
Catalytic application of sulfonic acid‐functionalized titana‐coated magnetic nanoparticles for the preparation of 1,8‐dioxodecahydroacridines and 2,4,6‐triarylpyridines via anomeric‐based oxidation
Authors: Zolfigol Mohammad Ali , Karimi Fatemeh , Yarie Meysam , Torabi Morteza 
Published: October 2017

We have developed green, efficient and powerful protocols for the preparation of 2,4,6‐triarylpyridines and 1,8‐dioxodecahydroacridines in the presence of Fe3O4@TiO2@O2PO2(CH2)2NHSO3H as a sulfonic acid‐functionalized titana‐coated magnetic nanoparticle catalyst under mild and solvent‐free reaction conditions. These protocols furnished the desired products in short reaction times with good to high yields (20–40 min and 80–86% in the case of 2,4,6‐triarylpyridines; 15–90 min and 80–93% in the case of 1,8‐dioxodecahydroacridines). The final step of the mechanistic route in the synthesis of 2,4,6‐triarylpyridines proceeds via an anomeric‐based oxidation. Also, the nanomagnetic core–shell catalyst can be recycled and reused in both cases of the scrutinized one‐pot multicomponent reactions with high turnover number and turnover frequency.
Biofouling alleviation and flux enhancement of electrospun PAN microfiltration membranes by embedding of para‐aminobenzoate alumoxane nanoparticles
Authors: Moradi G. , Rajabi L. , Dabirian F. , Zinadini S. 
Published: October 2017

ABSTRACTMembrane bioreactor (MBR) as a hybrid technology for wastewater treatment is becoming more popular for wastewater treatment. However, membrane fouling has hindered the widespread application of MBRs. Many efforts have been done for fouling mitigation. In this study, high flux and antifouling microfiltration membranes with unique surface structure, high surface porosity, and permeability were prepared by electrospinning technique. Initially, the optimum thickness of electrospun polyacrylonitrile (PAN) membranes was determined and then, electrospun PAN membrane at optimum thickness were prepared by embedding para‐aminobenzoate alumoxane (PABA) nanoparticles at different concentrations. The effect of PABA nanoparticles on membrane performance was investigated. To investigate the characterization of the prepared membranes Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, energy dispersive X‐ray spectroscopy, and water contact angle measurement were employed. The flux recovery ratio results revealed that the antifouling properties of the electrospun PAN membrane were enhanced by modification. The 3 wt % electrospun PABA embedded PAN had the best permeability, hydrophilicity, and antifouling properties among the fabricated membranes and showed remarkable reusability during filtration. The results obtained suggested that the high flux and antifouling electrospun PAN membranes embedded PABA nanoparticles could be used as MBR membranes. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45738.
A carbonothioate‐based highly selective fluorescent probe with a large Stokes shift for detection of Hg2+
Authors: Xu Jing , Xu Zhenghe , Wang Zuokai , Liu Caiyun , Zhu Baocun , Wang Xiuru , Wang Kun , Wang Jiangting , Sang Guoqing 
Published: October 2017

AbstractMercury (Hg) is one of the heavy metal pollutants in the environment. Even a very small amount of mercury can cause serious harm to human beings. Herein, we reported a new carbonothioate‐based fluorescent probe for the detection of Hg2+ without interference from other metal ions. This probe possessed a very large Stokes shift (192 nm), which could improve the detection sensitivity by minimizing the interferences resulted from self‐absorption or auto‐fluorescence. With the addition of Hg2+ to the probe solution, considerable fluorescence enhancement was observed. Additionally, the Hg2+ concentration of 0–16 μM and fluorescence intensity showed a good linear relationship (y = 22106× + 53108, R2 = 0.9955). Finally, the proposed probe was used to detect Hg2+ in real water samples, and its result was satisfactory. Therefore, our proposed probe would provide a promising method for the determination of Hg2+ in the environment.
The determination of nitrite by a graphene quantum dot fluorescence quenching method without sample pretreatment
Authors: Jin Li , Wang Ying , Liu Fangtong , Yu Shihua , Gao Yan , Zhang Jianpo 
Published: October 2017

AbstractA method for quantitative analysis of nitrite was achieved based on fluorescence quenching of graphene quantum dots. To obtain reliable results, the effects of pH, temperature and reaction time on this fluorescence quenching system were studied. Under optimized conditions, decrease in fluorescence intensity of graphene quantum dots (F0/F) showed a good linear relationship with nitrite concentration between 0.007692–0.38406 mmol/L and 0.03623–0.13043 μmol/L; the limits of detection were 9.8 μmol/L and 5.4 nmol/L, respectively. Variable temperature experiments, UV absorption spectra and thermodynamic calculations were used to determine the quenching mechanism, and indicated that it was an exothermic, spontaneous dynamic quenching process. This method was used to analyse urine samples, and showed that it could be applied to analyse biological samples.
Exploring the influence of hyperthermophilic protein Ssh10b on the stability and conformation of RNA by molecular dynamics simulation
Authors: Zhang Xue , Zheng Qing‐Chuan 
Published: October 2017

AbstractThe hyperthermophilic Ssh10b from Sulfolobus shibatae is a member of the Sac10b family, which binds RNA in vivo as a physiological substrate, and it has been postulated to play a key role in chromosomal organization in Archaea. Even though the crystal structure of Ssh10b‐RNA was resolved successively by X‐ray diffraction (Protein Data Bank [PDB] code: 3WBM), the detailed dynamic characteristics of Ssh10b‐RNA are still unclear. In this study, molecular dynamics (MDs) simulations at 6 temperatures (300, 350, 375, 400, 450, and 500 K) and molecular mechanics Generalized‐Born surface area (MM‐GB/SA) free energy calculations were performed to investigate the mechanism of how Ssh10b protects and stabilizes RNA. The simulation results indicate that RNA is stabilized by Ssh10b when the temperature rises up to 375 K. RNA is found to undergo conformational transition between A‐RNA and A′‐RNA when Ssh10b binds to RNA at 3 different temperatures (300, 350, and 375 K). Salt bridges, hydrogen bonds and hydrophobic interactions are observed, and some residues have significant impact on the structural stability of the complex. This study increases our understanding of the dynamics and interaction mechanism of hyperthermophilic proteins and RNA at the atomic level, and offers a model for studying the structural biology of hyperthermophilic proteins and RNA.
Desipramine‐induced lysosomal vacuolization is independent of autophagy
Authors: Sawai Hirofumi 
Published: October 2017

AbstractDesipramine, a commonly used antidepressant drug, induced cytosolic vacuolization in L929 cells. The level of LC3‐II was elevated and that of p62 was reduced in desipramine‐treated L929 cells, indicating the induction of autophagy by desipramine. Surprisingly, massive vacuolization was observed in desipramine‐treated L929 cells in the presence of LY294002, an inhibitor of autophagy. On the other hand, bafilomycin A1, an inhibitor of vacuolar type H+ ATPase, almost completely inhibited vacuolization in desipramine‐ or desipramine/LY294002‐treated L929 cells. Furthermore, desipramine‐induced vacuolization was observed in autophagy‐deficient Atg7−/− mouse embryonic fibroblasts (MEFs) as well as wild‐type Atg7+/+ MEFs. These results demonstrate that desipramine‐induced lysosomal vacuolization is independent of autophagy.
Isolation and characterization of human mesenchymal stem cells derived from synovial fluid by magnetic‐activated cell sorting (MACS)
Authors: Jia Zhaofeng , Liang Yujie , Xu Xiao , Li Xingfu , Liu Qisong , Ou Yangkan , Duan Li , Zhu Weimin , Lu Wei , Xiong Jianyi , Wang Daping 
Published: October 2017

AbstractMesenchymal stem cells (MSCs) are the primary source of cells used for cell‐based therapy in tissue engineering. MSCs are found in synovial fluid, a source that could be conveniently used for cartilage tissue engineering. However, the purification and characterization of SF‐MSCs has been poorly documented in the literature. Here, we outline an easy‐to‐perform approach for the isolation and culture of MSCs derived from human synovial fluid (hSF‐MSCs). We have successfully purified hSF‐MSCs using magnetic‐activated cell sorting (MACS) using the MSC surface marker, CD90. Purified SF‐MSCs demonstrate significant renewal capacity following several passages in culture. Furthermore, we demonstrated that MACS‐sorted CD90+ cells could differentiated into osteoblasts, adipocytes, and chondrocytes in vitro. In addition, we show that these cells can generate cartilage tissue in micromass culture as well. This study demonstrates that MACS is a useful tool that can be used for the purification of hSF‐MSCs from synovial fluid. The proliferation properties and ability to differentiate into chondrocytes make these hSF‐MSCs a promising source of stem cells for applications in cartilage repair.
Novel use of cutting balloon to treat subintimal hematomas during chronic total occlusion interventions
Authors: Vo Minh N. , Brilakis Emmanouil S. , Grantham J. Aaron 
Published: October 2017

AbstractContemporary chronic total occlusion (CTO) percutaneous coronary interventional (PCI) techniques are increasingly dependent upon dissection and reentry techniques (DARTs) especially for long occluded lesions. DARTs can result in compressive hematomas during CTO interventions and traditional treatment with balloon angioplasty and/or coronary stenting are often suboptimal and may extend the hematoma distally. We describe the novel use of a cutting balloon to “express” these compressive hematomas and restore antegrade coronary blood flow.
Meta‐analysis of transfemoral TAVR versus surgical aortic valve replacement
Authors: Arora Sameer , Vaidya Satyanarayana R. , Strassle Paula D. , Misenheimer Jacob A. , Rhodes Jeremy A. , Ramm Cassandra J. , Wheeler Evan N. , Caranasos Thomas G. , Cavender Matthew A. , Vavalle John P. 
Published: October 2017

AbstractBackgroundIn the recently concluded PARTNER 2 trial, TF‐TAVR cohort was shown to have lower risks of death or disabling strokes as compared to SAVR, whereas the outcomes with transthoracic TAVR were comparable with SAVR.MethodsWe searched PubMed, EMBASE, Web of Science, and Google Scholar for all comparison studies between TAVR and SAVR and mortality as an outcome, irrespective of surgical risk. Randomized controlled trials and propensity‐score‐matched cohort studies that used a transfemoral approach exclusively or stratified results by route of access and reported data for TF‐TAVR patients were eligible for inclusion. Outcomes of interest included 30‐day and 1‐year mortality, and 30‐day complications. If significant heterogeneity was found in the random effects meta‐analyses, a sensitivity analysis which individually removed each study was conducted.ResultsSeven studies reported results on TF‐TAVR. Compared with SAVR, TF‐TAVR had comparable 30‐day mortality (RR 0.79, 95% CI 0.58, 1.06), 1‐year mortality (RR 0.91, 95% CI 0.78, 1.08) and 30‐day risk of bleeding (RR 0.70, 95% CI 0.31, 1.57). However, TF‐TAVR was associated with lower 30‐day risks of atrial fibrillation (RR 0.28, 95% CI 0.17, 0.45), acute kidney injury (RR 0.38, 95% CI 0.20, 0.71), and myocardial infarction (RR 0.41, 95% CI 0.23, 0.75) at a cost of higher incidences of vascular complications (RR 6.10, 95% CI 2.92, 12.73) and pacemaker implantations (RR 3.29, 95% CI 1.41, 7.65).ConclusionsTF‐TAVR is associated with lower 30‐day risks of myocardial infarction compared to SAVR. Further studies are required to investigate the role of myocardial injury on overall TF‐TAVR outcomes.
Comparison of transcatheter and surgical treatment of paravalvular leak: Results from a 5‐year follow‐up study
Authors: Zhang Youjun , Pan Xin , Qu Xinkai , Wang Cheng , Huang Estella , Ma Lan , Wu Weihua , Fang Weiyi 
Published: October 2017

AbstractObjectiveThis study aimed to compare the efficacy and safety of two different treatments of paravalvular leak (PVL).BackgroundPVL is a common complication after surgical valve replacement. Re‐operation is associated with high mortality, morbidity, and risk of re‐leak. Catheter‐based repair has emerged as a promising new therapy.Methods and ResultsEighty‐seven consecutive patients with symptomatic PVL received either transcatheter (n = 46) or surgical (n = 41) treatment at Shanghai Chest Hospital between January 2009 and December 2015.The procedural and clinical success rates were similar between the transcatheter group and the surgical group (82.6 vs. 90.2%; P = 0.30; and 69.5 vs. 73.0%; P = 0.71, respectively). There were fewer in‐hospital total major adverse events in the transcatheter group (56.09 vs. 17.39%; P < 0.001), and transcatheter repair was more cost‐effective, with fewer blood transfusions, shorter procedure durations, shorter hospital stays, and less expenditure. However, there were six cases of hemolysis aggravation in the transcatheter group (13.04%). The 5‐year overall survival rates after transcatheter and surgical repair were 74.39 and 71.95% (P = 0.45), respectively, and the cardiac‐related survival rates were 84.08 and 74.72% (P = 0.19), respectively.ConclusionTranscatheter and surgical repairs are both effective treatments for selected patients with PVL. And, transcatheter closure seems to be safer and more cost‐effective. Nonetheless, this new treatment may be risky for post‐procedure hemolysis when unsuitable devices are used.
Predictors of in‐hospital effectiveness and complications of rotational atherectomy (from the ORPKI Polish National Registry 2014–2016)
Authors: Januszek Rafał , Siudak Zbigniew , Dziewierz Artur , Dudek Dariusz , Bartuś Stanisław 
Published: October 2017

AbstractObjectiveThe aim of the study was to assess trends in the use and periprocedural outcomes of rotational atherectomy (RA) in Poland between January 2014 and December 2016.BackgroundIn recent years, due to the aging population, RA is becoming more commonly used to treat heavily calcified coronary artery stenoses.MethodsData were prospectively collected using the Polish Cardiovascular Intervention Society national registry on all percutaneous coronary intervention (PCI) procedures performed in Poland. In total, 1,175 RA procedures were recorded from 317,175 PCI procedures (incidence of 0.37%).ResultsPatients undergoing RA were older (71.7 ± 9.7 vs. 66.9 ± 10.8, P < 0.00001) and less often males (68.3% vs. 76.4%, P < 0.00001). The complication rate was significantly higher in the RA group (P = 0.0012) with the leading coronary artery perforation (CAP) (P < 0.0001). Complication frequency decreased significantly in the last 3 years and was accompanied by an increase in the percentage of radial access and patients with stable angina. Among several predictors of the use of RA during PCI in multivariate analysis, the strongest one was previous coronary artery by‐pass grafting (P < 0.0001), whereas the strongest, predictor of CAP was the RA procedure (P = 0.00004). The increase in RA frequency over the last 3 years may reflect population aging, some fluctuations in indications for RA and reimbursement policies.ConclusionsWe observed a substantial increase in the utilization of RA during PCIs performed in Poland; however, it still needs to be increased. Decreased frequency of RA procedures follows change in indications for RA and vascular access. Periprocedural complication rates significantly decreased over the last 3 years.
Percutaneous axillary arteriotomy closure during transcatheter aortic valve replacement using the MANTA device
Authors: De Palma Rodney , Rück Andreas , Settergren Magnus , Saleh Nawzad 
Published: October 2017

AbstractPercutaneous aortic valve replacement is performed predominantly via the transfemoral approach. The transaxillary (subclavian) approach may be utilized if an alternative route access is required. Conventional access and closure for this approach necessitates open surgical techniques. We report a nonsurgical fully percutaneous axillary TAVR using a collagen‐based vascular closure device.
One‐year clinical and computed tomography follow‐up after implantation of bioresorbable vascular scaffolds in patients with coronary chronic total occlusions
Authors: Maeremans Joren , Verhaert David , Pereira Bruno , Frambach Peter , Van Mieghem Carlos , Barbato Emanuele , Willems Endry , Vrolix Mathias , Dens Jo 
Published: October 2017

AbstractObjectivesTo assess the safety and efficacy of everolimus‐eluting bioresorbable scaffolds (BRS) in the treatment of chronic total occlusions (CTO) using noninvasive multislice computed tomography (MSCT) angiography at one‐year follow‐up.BackgroundCurrent evidence regarding the safety and efficacy of BRS for the percutaneous treatment of CTO is limited.MethodsBetween September 2013 and January 2016, patients who received one or more ABSORB BRSs were included at three centers. MSCT (including quantitative analysis) and clinical follow‐up were performed at one year.ResultsForty‐one CTO patients were included. Mean age was 60 ± 11 years and the majority was male (83%). Average Japanese CTO (J‐CTO) score was 0.9 ± 0.9. Seventy‐one BRS were implanted in total with, on average, 1.7 ± 0.8 scaffolds/patient, and a total length of 43 ± 20 mm and diameter of 3.1 ± 0.4 mm. One noncardiac death took place. MSCT angiography was performed in 34 (83%) patients: all scaffolds were patent, except in one patient, in whom a patent target vessel was present on subsequent diagnostic angiography. MSCT quality was sufficient for quantitative analyses in 27 patients (46 scaffolds): median reference versus scaffold minimal lumen diameter and minimal lumen area were measured, and showed a small difference of 0.1 mm (−0.2–0.4) (lumen diameter stenosis = 3.0%) and 0.5 mm2 (−1.0–2.0) (lumen area stenosis = 4.2%).ConclusionsThe low number of events and high patency rate at 1 year are encouraging the further use of the ABSORB scaffold for CTOs with low J‐CTO score. Noninvasive MSCT angiography is a valid tool to assess scaffold patency, although its image resolution limits the use for quantitative measurements.
Structure Sensitivity of Acrolein Hydrogenation by Platinum Nanoparticles on BaxSr1−xTiO3Nanocuboids
Authors: Engelhardt Christopher M. , Kennedy Robert M. , Enterkin James A. , Poeppelmeier Kenneth R. , Ellis Donald E. , Marshall Christopher L. , Stair Peter C. 
Published: October 2017

AbstractThe structure sensitivity of Pt nanoparticles (PtN) for gas‐phase acrolein (AC) hydrogenation was probed for PtNon BaxSr1−xTiO3nanocuboid supports with (0 0 1) facets in a combined theoretical and experimental study. The in situ selectivity for allyl alcohol increased with the increase of the Sr concentration in the support, which corresponds to modifications in the stable Winterbottom shape and lattice strain of the Pt nanoparticles as a result of the interfacial energy between Pt and the BaxSr1−xTiO3supports. “Local model” nanofacets of the Pt surface, edge, and corner morphologies were developed as compact representations of adsorption and reaction sites. DFT was used as the primary modeling tool for the equilibrium adsorption states. We argue that adsorption on edge sites is critically important for the overall allyl alcohol selectivity of PtNcatalysts. A simple model was developed to represent PtNstrain effects caused by its interaction with the substrate. Bader topological atom, spherical volume averaging charge, and modified bond valence sum analyses were used to understand the bonding structure. Density of states analysis was performed for the structures of PtN, adsorbed AC, and intermediate products to examine adsorbate–particle interactions. The simulated hydrogenation of AC on PtNnanofacets was compared to the in situ hydrogenation of AC by PtNon BaxSr1−xTiO3to examine the effects of facet, edge, and corner sites on the overall selectivity.