bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hands and eyes, sight and touch: appraising the senses in Anglo-Saxon England
Authors: O'Keeffe Katherine O'Brien 
Published: July 2017

AbstractThe archives of knowledge through which Anglo-Saxons understood the senses ranged from vernacular to patristic. Quotidian understanding of the senses treated them as functions of their corresponding bodily organs, as the injury tariffs of Æthelberht and Alfred illustrate. Old English learned prose catalogues the senses from sight to touch with an order that bespeaks a set of understandings about bodies, materiality, souls and salvation. There the differing appraisals of sight and its lesser sibling, touch, track their perceived mediations between the world and the soul. The Old English Boethius, Wærferth's Dialogues and a range of Ælfric's writings illustrate understandings of these senses’ mediation between the material and the immaterial, the corporeal and the incorporeal. The meaning of Wulfstan's legislation on friðlice steora must thus be sought in a crossing of archives of appraisals – the legal valuation of body parts and the patristic understanding of senses as channels between the flesh and the spirit.
The Fuller Brooch and Anglo-Saxon depictions of dance
Authors: Bayless Martha 
Published: July 2017

AbstractThe scattered nature of references to dance and the ambiguity of its vocabulary have obscured Anglo-Saxon dance practices, but evidence suggests that dance was a significant cultural phenomenon. The earlier centuries of the Anglo-Saxon period saw the depiction of weapon dances, and later sources also allow us a glimpse of lively secular dance. Performance traditions may have included dance combined with satirical songs, as well as possible secular ritual dance. Finally, scripture provided examples of both holy dance and lascivious female dance. Contemporary iconography of these dance practices, combined with continued associations between dance and music, allow us to understand the conventions in the depiction of dance, and in turn these suggest that the figure of ‘Hearing’ on the Fuller Brooch, traditionally regarded as running, is in fact dancing.
The Seafarer, Grammatica, and the making of Anglo-Saxon textual culture
Authors: Walton Audrey 
Published: July 2017

AbstractDespite the popularity of The Seafarer within Old English scholarship, the poem's governing logic remains unclear, in large part because of the enduring mystery surrounding the poem's use of the compound expression forþon. This study will argue that the repeated use of forþon in The Seafarer reflects the anaphoric repetition of causatives in the Psalter. Moreover, through its repetition of forþon clauses, the poem invites the reader to approach the text using interpretive strategies commonly associated with the Psalms. Especially in the commentaries of Augustine, Cassiodorus and Origen, allegorical interpretation of the Psalms is linked to theories of subjectivity: different levels of the Psalms’ meaning often reflect different interpretations of the Psalms’ first- person speaker. Drawing on this link between biblical allegory and patristic theories of the self, The Seafarer uses the Old English Psalms as a backdrop against which to develop a specifically Anglo-Saxon model of Christian subjectivity and asceticism. In the layered complexity of its imagery, the poem offers more than vernacular glossing of originally Latin allegory: it creates allegorical figures within the medium of Old English. Implicitly, the poem makes claims for the medium of the vernacular, as well as for the model of subjectivity belonging to it, as a vehicle for reflection and contemplation.
The earliest modern Anglo-Saxon grammar: Sir Henry Spelman, Abraham Wheelock and William Retchford
Authors: Lucas Peter J. 
Published: July 2017

AbstractThe first scholars interested in Anglo-Saxon had to learn it by direct contact with original sources. Work on a dictionary preceded that on a grammar, notably through the efforts of John Joscelyn, Archbishop Parker's Latin Secretary. Like Parker, Sir Henry Spelman (1563/4–1641) found that many of his sources for early English history were in Anglo-Saxon. Consequently he encouraged the study of Old English by establishing a Lectureship in Anglo-Saxon at Cambridge University and worked closely with its first (and only) holder, Abraham Wheelock. Together with Wheelock's pupil, William Retchford, and possibly drawing on some earlier work by Joscelyn (since lost), these scholars attempted to formulate the rudiments of Anglo-Saxon grammar. This pioneering work, basically a parts-of-speech grammar, survives in three versions, two of them incomplete. In this article I discuss the contents and methodology used and present for the first time an edited text of the first modern Old English grammar. It was a remarkable achievement.
Spatial behaviour and density of three species of long-distance migrants wintering in a disturbed and non-disturbed woodland in northern Ghana
Authors: WILLEMOES MIKKEL , TØTTRUP ANDERS P. , LERCHE-JØRGENSEN MATHILDE , JACOBSEN ERIK MANDRUP , REEVE ANDREW HART , THORUP KASPER 
Published: July 2017

SummaryChanges in land-use and climate are threatening migratory animals worldwide. In birds, declines have been widely documented in long-distance migrants. However, reasons remain poorly understood due to a lack of basic information regarding migratory birds’ ecology in their non-breeding areas and the effects of current environmental pressures there. We studied bird densities, spatial and territorial behaviour and habitat preference in two different habitat types in northern Ghana, West Africa. We study three common Eurasian-African songbirds (Willow Warbler Phylloscopus trochilus, Melodious Warbler Hippolais polyglotta and Pied Flycatcher Ficedula hypoleuca) in a forested site, heavily disturbed by agricultural activities, and a forest reserve with no agriculture. The three species differed in non-breeding spatial strategies, with Willow Warblers having larger home ranges and being non-territorial. Home ranges (kernel density) of the three species were on average 1.5–4 times larger in the disturbed site than in the undisturbed site. Much of the birds’ tree species selection was explained by their preference for tall trees, but all species favoured trees of the genus Acacia. The overall larger home ranges in the disturbed site were presumably caused by the lower density of tall trees. Density of Pied Flycatchers was 24% lower in disturbed habitat (not significantly different from undisturbed) but Willow Warbler density in the disturbed habitat was more than 2.5 times the density in undisturbed. This suggests that the disturbed habitat was less suitable for Pied Flycatcher but not for Willow Warbler. This difference is possibly related to differences in tree species preferences and suggests that at least for some species, presence of preferred tree species is more important than overall tree abundance. Such information is crucial for predicting consequences of habitat changes on larger scales and population levels, as well as for planning potentially migrant-friendly farming practices.
Seed longevity and physical dormancy break of two endemic species of Dimorphandra from Brazilian biodiversity hotspots
Authors: Matheus Miele T. , Rodrigues-Junior Ailton G. , Oliveira Denise M.T. , Garcia Queila S. 
Published: July 2017

AbstractSeed longevity is dependent on seed traits and storage conditions. This study evaluated the seed longevity and physical dormancy (PY)-break of two species of Dimorphandra endemic to Brazilian biodiversity hotspots. Longevity was tested in situ, by burying seeds in their natural habitats (12 months), and ex situ, by storage in a cold chamber (5°C; 24 months). Seeds were taken at regular intervals to assess germinability at 30°C (12 h photoperiod) using intact and scarified seeds. Intact seeds (freshly collected, and after 12 months storage) were analysed using scanning electron microscopy. The germinability of freshly collected seeds of both species reached approximately 10% for intact seeds and >85% for scarified seeds. Cold storage maintained seed viability in both species, and broke dormancy for 35% of D. wilsonii seeds. After 12 months, only 55% (for D. exaltata) and 41% (for D. wilsonii) of the buried seeds were recovered; more than 90% of which remained viable in both species. Seeds gradually overcame PY during burial, with a higher germination increase for D. wilsonii (71%) than D. exaltata (32%). Dimorphandra exaltata seeds did not show clear structural changes after cold storage although D. wilsonii seeds evidently experience an increase in the depth of fracture lines. Burial promoted deep seed coat changes in both species, more intense in D. wilsonii, indicating that temperature and humidity variations throughout the year are among the main factors releasing Dimorphandra seeds from PY. The seeds of both studied species overcame PY during burial and are able to form small persistent soil seed banks.
Developing and validating a nutrition knowledge questionnaire: key methods and considerations
Authors: Trakman Gina Louise , Forsyth Adrienne , Hoye Russell , Belski Regina 
Published: July 2017

AbstractObjectiveTo outline key statistical considerations and detailed methodologies for the development and evaluation of a valid and reliable nutrition knowledge questionnaire.DesignLiterature on questionnaire development in a range of fields was reviewed and a set of evidence-based guidelines specific to the creation of a nutrition knowledge questionnaire have been developed. The recommendations describe key qualitative methods and statistical considerations, and include relevant examples from previous papers and existing nutrition knowledge questionnaires. Where details have been omitted for the sake of brevity, the reader has been directed to suitable references.ResultsWe recommend an eight-step methodology for nutrition knowledge questionnaire development as follows: (i) definition of the construct and development of a test plan; (ii) generation of the item pool; (iii) choice of the scoring system and response format; (iv) assessment of content validity; (v) assessment of face validity; (vi) purification of the scale using item analysis, including item characteristics, difficulty and discrimination; (vii) evaluation of the scale including its factor structure and internal reliability, or Rasch analysis, including assessment of dimensionality and internal reliability; and (viii) gathering of data to re-examine the questionnaire’s properties, assess temporal stability and confirm construct validity. Several of these methods have previously been overlooked.ConclusionsThe measurement of nutrition knowledge is an important consideration for individuals working in the nutrition field. Improved methods in the development of nutrition knowledge questionnaires, such as the use of factor analysis or Rasch analysis, will enable more confidence in reported measures of nutrition knowledge.
BioRock: new experiments and hardware to investigate microbe–mineral interactions in space
Authors: Loudon Claire-Marie , Nicholson Natasha , Finster Kai , Leys Natalie , Byloos Bo , Van Houdt Rob , Rettberg Petra , Moeller Ralf , Fuchs Felix M. , Demets René , Krause Jutta , Vukich Marco , Mariani Alessandro , Cockell Charles 
Published: July 2017

AbstractIn this paper, we describe the development of an International Space Station experiment, BioRock. The purpose of this experiment is to investigate biofilm formation and microbe–mineral interactions in space. The latter research has application in areas as diverse as regolith amelioration and extraterrestrial mining. We describe the design of a prototype biomining reactor for use in space experimentation and investigations onin situResource Use and we describe the results of pre-flight tests.
Inverted battery design as ion generator for interfacing with biosystems
Authors: Wang Chengwei , Fu Kun , Dai Jiaqi , Lacey Steven D. , Yao Yonggang , Pastel Glenn , Xu Lisha , Zhang Jianhua , Hu Liangbing 
Published: July 2017

AbstractIn a lithium-ion battery, electrons are released from the anode and go through an external electronic circuit to power devices, while ions simultaneously transfer through internal ionic media to meet with electrons at the cathode. Inspired by the fundamental electrochemistry of the lithium-ion battery, we envision a cell that can generate a current of ions instead of electrons, so that ions can be used for potential applications in biosystems. Based on this concept, we report an ‘electron battery’ configuration in which ions travel through an external circuit to interact with the intended biosystem whereas electrons are transported internally. As a proof-of-concept, we demonstrate the application of the electron battery by stimulating a monolayer of cultured cells, which fluoresces a calcium ion wave at a controlled ionic current. Electron batteries with the capability to generate a tunable ionic current could pave the way towards precise ion-system control in a broad range of biological applications.
Distribution of high-dimensional entanglement via an intra-city free-space link
Authors: Steinlechner Fabian , Ecker Sebastian , Fink Matthias , Liu Bo , Bavaresco Jessica , Huber Marcus , Scheidl Thomas , Ursin Rupert 
Published: July 2017

AbstractQuantum entanglement is a fundamental resource in quantum information processing and its distribution between distant parties is a key challenge in quantum communications. Increasing the dimensionality of entanglement has been shown to improve robustness and channel capacities in secure quantum communications. Here we report on the distribution of genuine high-dimensional entanglement via a 1.2-km-long free-space link across Vienna. We exploit hyperentanglement, that is, simultaneous entanglement in polarization and energy-time bases, to encode quantum information, and observe high-visibility interference for successive correlation measurements in each degree of freedom. These visibilities impose lower bounds on entanglement in each subspace individually and certify four-dimensional entanglement for the hyperentangled system. The high-fidelity transmission of high-dimensional entanglement under real-world atmospheric link conditions represents an important step towards long-distance quantum communications with more complex quantum systems and the implementation of advanced quantum experiments with satellite links.
Overexpression of zinc finger protein 687 enhances tumorigenic capability and promotes recurrence of hepatocellular carcinoma
Authors: Zhang T , Huang Y , Liu W , Meng W , Zhao H , Yang Q , Gu S-J , Xiao C-C , Jia C-C , Zhang B , Zou Y , Li H-P , Fu B-S 
Published: July 2017

AbstractZinc finger protein 687 (ZNF687), identified as a C2H2 zinc finger protein, has been found to be mutated and upregulated in giant cell tumor of bone and acute myeloid leukemia, suggesting an oncogenic role for ZNF687 in cancer. However, the clinical significance and precise role of ZNF687 in cancer progression are largely unknown. Herein, we report that ZNF687 was markedly upregulated in hepatocellular carcinoma (HCC) cell lines and HCC tissues, and was significantly correlated with relapse-free survival in HCC. ZNF687 overexpression greatly enhanced HCC cell capability for tumorsphere formation, invasion and chemoresistance in vitro, whereas inhibiting ZNF687 reduced these capabilities and inhibited HCC cell tumorigenic capability in vivo. Importantly, extreme limiting dilution analysis revealed that even 1 × 102 ZNF687-transduced cells could form tumors in vivo, indicating that ZNF687 contributes to HCC recurrence. Moreover, we demonstrate that ZNF687 transcriptionally upregulated the expression of the pluripotency-associated factors BMI1, OCT4 and NANOG by directly targeting their promoters. Therefore, our results suggest that ZNF687 has a promoter role in regulating HCC progression, which provides a potential therapeutic target for HCC in humans.
Sorting at embryonic boundaries requires high heterotypic interfacial tension
Authors: Canty Laura , Zarour Eleyine , Kashkooli Leily , François Paul , Fagotto François 
Published: July 2017

AbstractThe establishment of sharp boundaries is essential for segregation of embryonic tissues during development, but the underlying mechanism of cell sorting has remained unclear. Opposing hypotheses have been proposed, either based on global tissue adhesive or contractile properties or on local signalling through cell contact cues. Here we use ectoderm–mesoderm separation in Xenopus to directly evaluate the role of these various parameters. We find that ephrin-Eph-based repulsion is very effective at inducing and maintaining separation, whereas differences in adhesion or contractility have surprisingly little impact. Computer simulations support and generalise our experimental results, showing that a high heterotypic interfacial tension between tissues is key to their segregation. We propose a unifying model, in which conditions of sorting previously considered as driven by differential adhesion/tension should be viewed as suboptimal cases of heterotypic interfacial tension.
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice
Authors: Xie Kan , Neff Frauke , Markert Astrid , Rozman Jan , Aguilar-Pimentel Juan Antonio , Amarie Oana Veronica , Becker Lore , Brommage Robert , Garrett Lillian , Henzel Kristin S. , Hölter Sabine M. , Janik Dirk , Lehmann Isabelle , Moreth Kristin , Pearson Brandon L. , Racz Ildiko , Rathkolb Birgit , Ryan Devon P. , Schröder Susanne , Treise Irina , Bekeredjian Raffi , Busch Dirk H. , Graw Jochen , Ehninger Gerhard , Klingenspor Martin , Klopstock Thomas , Ollert Markus , Sandholzer Michael , Schmidt-Weber Carsten , Weiergräber Marco , Wolf Eckhard , Wurst Wolfgang , Zimmer Andreas , Gailus-Durner Valerie , Fuchs Helmut , Hrabě de Angelis Martin , Ehninger Dan 
Published: July 2017

AbstractDietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls. We also analyze the effects of every-other-day feeding on young mice on shorter-term every-other-day feeding or ad libitum to account for possible aging-independent restriction effects. Our large-scale analysis reveals overall only limited evidence for a retardation of the aging rate in every-other-day feeding mice. The data indicate that every-other-day feeding-induced longevity is sufficiently explained by delays in life-limiting neoplastic disorders and is not associated with a more general slowing of the aging process in mice.
KRAS Activation and over-expression of SIRT1/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance
Authors: Yoo Jung-Yoon , Kim Tae Hoon , Fazleabas Asgerally T. , Palomino Wilder A. , Ahn Soo Hyun , Tayade Chandrakant , Schammel David P. , Young Steven L. , Jeong Jae-Wook , Lessey Bruce A. 
Published: July 2017

AbstractEndometriosis is an inflammatory condition that is associated with progesterone resistance and cell proliferation, resulting in pain, infertility and pregnancy loss. We previously demonstrated phosphorylation of STAT3 in eutopic endometrium of infertile women with this disorder leading to over-expression of the oncogene BCL6 and stabilization of hypoxia-induced factor 1 alpha (HIF-1α). Here we report coordinated activation of KRAS and over-expression of Sirtuin 1 (SIRT1), a histone deacetylase and gene silencer, in the eutopic endometrium from women with endometriosis throughout the menstrual cycle. The mice with conditional activation of KRAS in the PGR positive cells reveal an increase of SIRT1 expression in the endometrium compared to control mice. The expression of progesterone receptor target genes including the Indian Hedgehog pathway genes are significantly down-regulated in the mutant mice. SIRT1 co-localizes with BCL6 in the nuclei of affected individuals and both proteins bind to and suppress the promoter of GLI1, a critical mediator of progesterone action in the Indian Hedgehog pathway, by ChIP analysis. In eutopic endometrium, GLI1 expression is reduced in women with endometriosis. Together, these data suggest that KRAS, SIRT1 and BCL6 are coordinately over-expressed in eutopic endometrium of women with endometriosis and likely participate in the pathogenesis of endometriosis.
Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions
Authors: Liu Fang , Zhang Na , Li Zhaojie , Wang Xiong , Shi Hongjie , Xue Changhu , Li Robert W. , Tang Qingjuan 
Published: July 2017

AbstractChondroitin sulfate (CS) has been widely used for medical and nutraceutical purposes due to its roles in maintaining tissue structural integrity. We investigated if CS disaccharides may act as a bioactive compound and modulate gut microbial composition in mice. Our data show that CS disaccharides supplementation for 16 days significantly reduced blood LPS in the mice experiencing exhaustive exercise stress. CS disaccharides partially restored total fecal short-chain fatty acids from the level significantly repressed in mice under the stress. Our findings demonstrated that CS was likely butyrogenic and resulted in a significant increase in fecal butyrate concentration. CS disaccharides had a profound impact on gut microbial composition, affecting the abundance of 13.6% and 7.3% Operational Taxonomic Units in fecal microbial communities in healthy and stressed mice, respectively. CS disaccharides reduced the prevalence of inflammatory Proteobacteria. Together, our findings demonstrated that CS may ameliorate stress-induced intestinal inflammation. Furthermore, CS significantly increased intestinal Bacteroides acidifaciens population, indirectly exerting its immunomodulatory effect on the intestine. CS disaccharides had a significant impact on a broad range of biological pathways under stressed condition, such as ABC transporters, two-component systems, and carbohydrate metabolism. Our results will facilitate the development of CS as a bioactive nutraceutical.
Oral exposure to arsenic causes hearing loss in young people aged 12–29 years and in young mice
Authors: Li Xiang , Ohgami Nobutaka , Omata Yasuhiro , Yajima Ichiro , Iida Machiko , Oshino Reina , Ohnuma Shoko , Ahsan Nazmul , Akhand Anwarul Azim , Kato Masashi 
Published: July 2017

AbstractThere is no information on the association between oral exposure to arsenic (As) and hearing loss in humans or mice. In this combined epidemiological study and experimental study, the association of oral exposure to As with hearing loss in people aged 12–29 years and young mice was examined. Subjects in the exposure group (n = 48), who were drinking tube well water contaminated with As, showed significantly higher risks of hearing loss at 4 kHz [odds ratio (OR) = 7.60; 95% confidence interval (CI): 1.56, 57.88], 8 kHz (OR = 5.00; 95% CI: 1.48, 18.90) and 12 kHz (OR = 8.72; 95% CI: 2.09, 47.77) than did subjects in the control group (n = 29). We next performed an experiment in which young mice were exposed to As via drinking water at 22.5 mg/L, which is a much greater concentration than that in human studies. The exposure group showed hearing loss and accumulation of As in inner ears. Ex vivo exposure of the organ of Corti from mice exposed to As significantly decreased the number of auditory neurons and fibers. Thus, our combined study showed that oral exposure to As caused hearing loss in young people and young mice.