bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review on Superconducting Materials
Authors: Hott Roland , Kleiner Reinhold , Wolf Thomas , Zwicknagl Gertrud 
Published: December 2016

The article contains sections titled:IntroductionCuprate High‐Temperature SuperconductorsOther Oxide SuperconductorsIron‐Based SuperconductorsOther Chalcogenide SuperconductorsHeavy Fermion SuperconductorsNitride SuperconductorsOrganic and Other Carbon‐ and Silicon‐Based SuperconductorsBorides and Borocarbides
Magnets forNMRandMRI
Authors: Iwasa Yukikazu , Hahn Seungyong 
Published: December 2016

The article contains sections titled:Introduction toNMRandMRIMagnetsSpecific Design Issues forNMRandMRIMagnetsStatus (2013) ofNMRandMRIMagnetsHTSApplications toNMRandMRIMagnetsConclusions
Correlative atom probe tomography and electron microscopy on energy materials
Authors: Stoffers Andreas , Liebscher Christian , Choi Pyuck‐Pa , Herbig Michael , Scheu Christina , Dehm Gerhard , Povstugar Ivan , Raabe Dierk 
Published: December 2016

We present recent progress in correlative methods for the joint analysis of samples by Atom Probe Tomography (LEAP 3000, LEAP 5000) and Electron Microscopy (Cs corrected Titan Themis). Measurements are conducted on the same Atom Probe sample tips and in some cases atomic resolution is reached.
Examples from functional and structural energy‐related materials are presented including segregation effects in multicrystalline silicon solar cells and their relation to cell efficiency (Fig. 1), superalloys for advanced turbines and high strength steels (Fig. 2).
Biallelic SCN10A mutations in neuromuscular disease and epileptic encephalopathy
Authors: Kambouris Marios , Thevenon Julien , Soldatos Ariane , Cox Allison , Stephen Joshi , Ben‐Omran Tawfeg , Al‐Sarraj Yasser , Boulos Hala , Bone William , Mullikin James C. ,   NISC Comparative Sequencing Program, Masurel‐Paulet Alice , St‐Onge Judith , Dufford Yannis , Chantegret Corrine , Thauvin‐Robinet Christel , Al‐Alami Jamil , Faivre Laurence , Riviere Jean Baptiste , Gahl William A. , Bassuk Alexander G. , Malicdan May Christine V. , El‐Shanti Hatem 
Published: December 2016

AbstractObjectivesTwo consanguineous families, one of Sudanese ethnicity presenting progressive neuromuscular disease, severe cognitive impairment, muscle weakness, upper motor neuron lesion, anhydrosis, facial dysmorphism, and recurrent seizures and the other of Egyptian ethnicity presenting with neonatal hypotonia, bradycardia, and recurrent seizures, were evaluated for the causative gene mutation.Methods and ResultsHomozygosity mapping and whole exome sequencing (WES) identified damaging homozygous variants in SCN10A, namely c.4514C>T; p.Thr1505Met in the first family and c.4735C>T; p.Arg1579* in the second family. A third family, of Western European descent, included a child with febrile infection‐related epilepsy syndrome (FIRES) who also had compound heterozygous missense mutations in SCN10A, namely, c.3482T>C; p.Met1161Thr and c.4709C>A; p.Thr1570Lys. A search for SCN10A variants in three consortia datasets (EuroEPINOMICS, Epi4K/EPGP, Autism/dbGaP) identified an additional five individuals with compound heterozygous variants. A Hispanic male with infantile spasms [c.2842G>C; p.Val948Leu and c.1453C>T; p.Arg485Cys], and a Caucasian female with Lennox–Gastaut syndrome [c.1529C>T; p.Pro510Leu and c.4984G>A; p.Gly1662Ser] in the epilepsy databases and three in the autism databases with [c.4009T>A; p.Ser1337Thr and c.1141A>G; p.Ile381Val], [c.2972C>T; p.Pro991Leu and c.2470C>T; p.His824Tyr], and [c.4009T>A; p.Ser1337Thr and c.2052G>A; p.Met684Ile].InterpretationSCN10A is a member of the voltage‐gated sodium channel (VGSC) gene family. Sodium channels are responsible for the instigation and proliferation of action potentials in central and peripheral nervous systems. Heterozygous mutations in VGSC genes cause a wide range of epileptic and peripheral nervous system disorders. This report presents autosomal recessive mutations in SCN10A that may be linked to epilepsy‐related phenotypes, Lennox–Gastaut syndrome, infantile spasms, and Autism Spectrum Disorder.
Familial amyloid polyneuropathy in Portugal: New genes modulating age‐at‐onset
Authors: Santos Diana , Coelho Teresa , Alves‐Ferreira Miguel , Sequeiros Jorge , Mendonça Denisa , Alonso Isabel , Lemos Carolina , Sousa Alda 
Published: December 2016

AbstractObjectivesFamilial amyloid polyneuropathy (FAP ATTRV30M) shows a wide variation in age‐at‐onset (AO) between clusters, families, and among generations. We will now explore some candidate genes involved in altered disease pathways in order to assess their role as genetic modifiers of AO, using a family‐centered approach.MethodsWe analyzed 62 tagging SNPs from nine genes‐NGAL, MMP‐9, BGN, MEK1, MEK2, ERK1, ERK2, HSP27, and YWHAZ – in a sample of 318 V30M Portuguese patients (106 families), currently under follow‐up. A generalized estimating equation analysis was used to take into account nonindependency of AO between relatives. Also, an in silico analysis was performed in order to assess the functional impact of significant variants associated with AO.ResultsWe found for the first time variants from six genes (NGAL, BGN (in the female group), MEK1, MEK2, HSP27, and YWHAZ) that were significantly associated with early‐ and/or late‐onset. Then, we confirmed a strong synergistic interaction between NGAL and MMP‐9 genes. Additionally, by an in silico analysis, we found some variants for MEK1 gene that may alter binding of the transcription factors and that influence the regulation of gene expression regarding microRNA binding sites and splicing regulatory factors.InterpretationThese findings showed that different genetic factors can modulate differently the onset of disease's symptoms and revealed new mechanisms with clinical implications in the genetic counseling and follow‐up of mutation carriers and could contribute for development of potential therapeutical targets.
Associations Between Clinical Evidence of Inflammation and Synovitis in Symptomatic Knee Osteoarthritis: A Cross‐Sectional Substudy
Authors: Wallace Gemma , Cro Suzie , Doré Caroline , King Leonard , Kluzek Stefan , Price Andrew , Roemer Frank , Guermazi Ali , Keen Richard , Arden Nigel 
Published: December 2016

ObjectivePainful knee osteoarthritis (KOA) has been associated with joint inflammation. There is, however, little literature correlating signs of localized inflammation with contrast‐enhanced (CE) magnetic resonance imaging (MRI) of synovium. This study examined the relationship between clinical and functional markers of localized knee inflammation and CE MRI–based synovial scores.MethodsPatients with symptomatic KOA were enrolled into the randomized, double‐blind, Vitamin D Evaluation in Osteoarthritis (VIDEO) trial. In this cross‐sectional substudy, associations between validated MRI‐based semiquantitative synovial scores of the knee and the following markers of inflammation were investigated: self‐reported pain and stiffness, effusion, warmth, joint line tenderness, erythrocyte sedimentation rate, radiographic severity, and functional ability tests.ResultsA total of 107 patients satisfied the inclusion criteria of complete data and were included in the analysis. Significant associations were found between the number of regions affected by synovitis and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, effusion, and joint line tenderness. Each additional region affected by synovitis was associated with an increase in WOMAC pain (1.82 [95% confidence interval (95% CI) 0.05, 3.58], P = 0.04), and the association with extent of medial synovitis was particularly strong (3.21 [95% CI 0.43, 5.99], P = 0.02). Extent of synovitis was positively associated with effusion (odds ratio 1.69 [95% CI 1.37, 2.08], P < 0.01) and negatively associated with joint line tenderness (relative risk 0.87 [95% CI 0.84, 0.90], P < 0.01).ConclusionThere is a strong positive association between synovitis and self‐reported patient pain and clinically detectable effusion. Nonoperative treatments directed at management of inflammation and future trials targeting the synovial tissue for treating KOA should consider these 2 factors as potential inclusion criteria.
Determinants of Patient‐Physician Discordance in Global Assessment in Psoriatic Arthritis: A Multicenter European Study
Authors: Desthieux Carole , Granger Benjamin , Balanescu Andra Rodica , Balint Peter , Braun Jürgen , Canete Juan D. , Heiberg Turid , Helliwell Philip S. , Kalyoncu Umut , Kvien Tore K. , Kiltz Uta , Niedermayer Dora , Otsa Kati , Scrivo Rossana , Smolen Josef , Stamm Tanja A. , Veale Douglas J. , de Vlam Kurt , de Wit Maarten , Gossec Laure 
Published: December 2016

ObjectivePatient‐physician discordance in global assessment of disease activity concerns one‐third of patients, but what does it reflect? We aimed to assess patient‐physician discordance in psoriatic arthritis (PsA) and patient‐reported domains of health (physical and psychological) associated with discordance.MethodsWe analyzed the PsAID (Psoriatic Arthritis Impact of Disease), a cross‐sectional, multicenter European study of patients with PsA according to expert opinion. Patient global assessment (PGA) and physician global assessment (PhGA) were rated on a 0–10 numeric rating scale. Discordance was defined as the difference (PGA−PhGA) and as the absolute difference |PGA−PhGA| ≥3 points. Determinants of PGA−PhGA were assessed by a stepwise multivariate linear regression among 12 physical and psychological aspects of impact: pain, skin problems, fatigue, ability to work/leisure, functional incapacity, feeling of discomfort, sleep disturbance, anxiety/fear, coping, embarrassment/shame, social participation, and depressive affects.ResultsIn 460 patients (mean ± SD age 50.6 ± 12.9 years, 52.2% female, mean ± SD disease duration 9.5 ± 9.5 years, mean ± SD Disease Activity Index for Psoriatic Arthritis score 30.8 ± 32.4, and 40.4% undergoing treatment with biologic agents), the mean ± SD PGA was higher than the mean PhGA, with a mean absolute difference of 1.9 ± 1.8 points. Discordance defined by |PGA−PhGA| ≥3 of 10 concerned 134 patients (29.1%), and 115 patients (85.8% of the patients with discordance) had PGA>PhGA. Higher fatigue (β = 0.14), lower self‐perceived coping (β = 0.23), and impaired social participation (β = 0.16) were independently associated with a higher difference (PGA−PhGA).ConclusionDiscordance concerned 29.1% of these patient/physician dyads, mainly by PGA>PhGA. Factors associated with discordance were psychological rather than physical domains of health. Discordance was more frequent in patients in remission, indicating more work is needed on the patient perspective regarding disease activity.
Prevalence of Primary Sjögren's Syndrome in a US Population‐Based Cohort
Authors: Maciel Gabriel , Crowson Cynthia S. , Matteson Eric L. , Cornec Divi 
Published: December 2016

ObjectiveTo report the point prevalence of primary Sjögren's syndrome (SS) in the first US population‐based study.MethodsCases of all potential primary SS patients living in Olmsted County, Minnesota, on January 1, 2015, were retrieved using Rochester Epidemiology Project resources, and ascertained by manual medical records review. Primary SS cases were defined according to physician diagnosis. The use of diagnostic tests was assessed and the performance of classification criteria was evaluated. The number of prevalent cases in 2015 was also projected based on 1976–2005 incidence data from the same source population.ResultsA total of 106 patients with primary SS were included in the study: 86% were female, with a mean ± SD age of 64.6 ± 15.2 years, and a mean ± SD disease duration of 10.5 ± 8.4 years. A majority were anti‐SSA positive (75%) and/or anti‐SSB positive (58%), but only 22% met American–European Consensus Group or American College of Rheumatology criteria, because the other tests required for disease classification (ocular dryness objective assessment, salivary gland functional or morphologic tests, or salivary gland biopsy) were rarely performed in clinical practice. According to the physician diagnosis, the age‐ and sex‐adjusted prevalence of primary SS was 10.3 per 10,000 inhabitants, but according to classification criteria, this prevalence was only 2.2 per 10,000. The analysis based on previous incidence data projected a similar 2015 prevalence rate of 11.0 per 10,000.ConclusionThe prevalence of primary SS in this geographically well‐defined population was estimated to be between 2 and 10 per 10,000 inhabitants. Physicians rarely used tests included in the classification criteria to diagnose the disease in this community setting.
Associations Between Five Important Domains of Health and the Patient Acceptable Symptom State in Rheumatoid Arthritis and Psoriatic Arthritis: A Cross‐Sectional Study of 977 Patients
Authors: Puyraimond‐Zemmour Déborah , Etcheto Adrien , Fautrel Bruno , Balanescu Andra , de Wit Maarten , Heiberg Turid , Otsa Kati , Kvien Tore K. , Dougados Maxime , Gossec Laure 
Published: December 2016

ObjectiveTo explore the link between a patient acceptable symptom state (PASS) and patient‐perceived impact in rheumatoid arthritis (RA) and psoriatic arthritis (PsA).MethodsThis was a cross‐sectional study of unselected patients with definite RA or PsA. Pain, functional capacity, fatigue, coping, and sleep disturbance were assessed using a numeric rating scale (0–10) and compared between patients in PASS or not (Cohen's effect sizes). The domains of health associated with PASS status were assessed by multivariate forward logistic regression, and PASS thresholds were determined using the 75th percentile method and receiver operating characteristic analyses.ResultsAmong 977 patients (531 with RA, 446 with PsA), the mean ± SD age was 53.4 ± 13.2 years, mean ± SD disease duration was 11.2 ± 10.0 years, and 637 (65.8%) were women. In all, 595 patients (60.9%) were in PASS; they had lower symptom levels, and all domains of health except sleep disturbance discriminated clearly between patients in PASS or not (effect sizes 0.73–1.45 in RA and 0.82–1.52 in PsA). In multivariate analysis, less pain and better coping were predictive of being in PASS. Odds ratios were: RA pain 0.80 (95% confidence interval [95% CI] 0.67–0.96), PsA pain 0.63 (95% CI 0.52–0.75), RA coping 0.84 (95% CI 0.74–0.96), and PsA coping 0.83 (95% CI 0.71–0.97). The cutoffs of symptom intensity (range 0–10), corresponding to PASS for the 5 domains of health and the 2 diseases were similar, i.e., approximately 4–5.ConclusionIn RA and PsA, PASS was associated with the 5 domains of health analyzed, and in particular with less pain and better coping.
Patients' Perceptions of Their Relatives' Risk of Developing Rheumatoid Arthritis and of the Potential for Risk Communication, Prediction, and Modulation
Authors: Falahee Marie , Simons Gwenda , Buckley Christopher D. , Hansson Mats , Stack Rebecca J. , Raza Karim 
Published: December 2016

ObjectiveTo understand the perspectives of patients with rheumatoid arthritis (RA) about the risk of their relatives developing RA in the future, and about communicating with their relatives concerning risk and its modulation.MethodsTwenty‐one RA patients took part in semistructured interviews.ResultsParticipants reported willingness to communicate with relatives about their risk of developing RA, but described choosing which relatives to communicate with, on the basis of the relatives' perceived receptivity to such risk information. Participants described the potential for risk information to cause negative emotions. Some participants did not consider RA to be hereditable, and few reported smoking as a risk factor. Patients described a lack of public awareness about the causes of RA and the negative impact that RA has on the quality of life. Awareness of this negative impact was identified as an important driver for predictive and preventive strategies. Participants held positive perceptions of predictive testing for RA, though the results of predictive tests were conceptualized as having a high degree of accuracy. Negative views of predictive testing were associated with an appreciation of the probabilistic nature of risk information. Participants felt that their relatives would prefer lifestyle modification over medication as a risk reduction strategy.ConclusionInformation about risk factors for RA, and the potential impact of RA on the quality of life, is needed to support family communication about RA risk. Management of expectations is needed in relation to the probabilistic nature of risk information, and appropriate support should be provided for negative psychological outcomes.
Finding Home: A Qualitative Approach to Understanding Adolescent Mothers’ Housing Instability
Authors: Elliott Margaret C. , Shuey Elizabeth A. , Zaika Natalya , Mims Lauren , Leventhal Tama 
Published: December 2016

AbstractMany low‐income Latina adolescent mothers face instability in their housing circumstances, which has implications for their long‐term prospects and that of their children. This study used longitudinal, ethnographic data from Welfare, Children, and Families: A Three‐City Study to explore experiences of low‐income, Latina adolescent mothers (N = 15) with unstable housing who primarily rely on their families or the families of their significant others for housing support. Results of analysis employing grounded theory and narrative approaches suggested two types of instability: “Horizontal moves” between family homes and “vertical moves” between family homes and independent living. Although family support often was fundamental in allowing for participants’ pursuit of independent housing (i.e., vertical moves), it also was associated with greater residential mobility (i.e., horizontal moves), most often in the context of intrafamilial conflict and family instability. These results are discussed with respect to inconsistencies in policies to address this vulnerable population.
Living Conditions and Psychological Distress in Latino Migrant Day Laborers: The Role of Cultural and Community Protective Factors
Authors: Organista Kurt C. , Ngo Samantha , Neilands Torsten B. , Kral Alex H. 
Published: December 2016

AbstractThe purpose of this study was to examine the relationship between typically difficult living conditions and psychological distress in Latino migrant day laborers (LMDLs), with attention to the potentially protective roles of contact with family in country of origin (i.e., communication, sending money, etc.), availability of local culture (i.e., food, music, people from one's country of origin), and utilization of community resources perceived to be culturally competent (i.e., services that are respectful, able to serve Latinos, able to solve problems, in Spanish, etc.). Participants were 344 LMDLs surveyed in the San Francisco Bay Area. As hypothesized: (a) difficult living conditions were related to depression, anxiety, and desesperación [desperation], the latter a popular Latino idiom of psychological distress recently validated on LMDLs; (b) contact with family moderated the relation between difficult living conditions and depression and desesperación but not anxiety and (c) access to local culture, and utilization of community resources, mediated the relation between difficult living conditions and depression and desesperación but not anxiety. Implications for intervening at local and larger levels in order to provide some protection against distress built into the LMDL experience in the United States are discussed.
Pathological correlations of [F‐18]‐AV‐1451 imaging in non‐alzheimer tauopathies
Authors: Marquié Marta , Normandin Marc D. , Meltzer Avery C. , Siao Tick Chong Michael , Andrea Nicolas V. , Antón‐Fernández Alejandro , Klunk William E. , Mathis Chester A. , Ikonomovic Milos D. , Debnath Manik , Bien Elizabeth A. , Vanderburg Charles R. , Costantino Isabel , Makaretz Sara , DeVos Sarah L. , Oakley Derek H. , Gomperts Stephen N. , Growdon John H. , Domoto‐Reilly Kimiko , Lucente Diane , Dickerson Bradford C. , Frosch Matthew P. , Hyman Bradley T. , Johnson Keith A. , Gómez‐Isla Teresa 
Published: December 2016

ObjectiveRecent studies have shown that positron emission tomography (PET) tracer AV‐1451 exhibits high binding affinity for paired helical filament (PHF)‐tau pathology in Alzheimer's brains. However, the ability of this ligand to bind to tau lesions in other tauopathies remains controversial. Our goal was to examine the correlation of in vivo and postmortem AV‐1451 binding patterns in three autopsy‐confirmed non‐Alzheimer tauopathy cases.MethodsWe quantified in vivo retention of [F‐18]‐AV‐1451 and performed autoradiography, [H‐3]‐AV‐1451 binding assays, and quantitative tau measurements in postmortem brain samples from two progressive supranuclear palsy (PSP) cases and a MAPT P301L mutation carrier. They all underwent [F‐18]‐AV‐1451 PET imaging before death.ResultsThe three subjects exhibited [F‐18]‐AV‐1451 in vivo retention predominantly in basal ganglia and midbrain. Neuropathological examination confirmed the PSP diagnosis in the first two subjects; the MAPT P301L mutation carrier had an atypical tauopathy characterized by grain‐like tau‐containing neurites in gray and white matter with heaviest burden in basal ganglia. In all three cases, autoradiography failed to show detectable [F‐18]‐AV‐1451 binding in multiple brain regions examined, with the exception of entorhinal cortex (reflecting incidental age‐related neurofibrillary tangles) and neuromelanin‐containing neurons in the substantia nigra (off‐target binding). The lack of a consistent significant correlation between in vivo [F‐18]‐AV‐1541 retention and postmortem in vitro binding and tau measures in these cases suggests that this ligand has low affinity for tau lesions primarily made of straight tau filaments.InterpretationAV‐1451 may have limited utility for in vivo selective and reliable detection of tau aggregates in these non‐Alzheimer tauopathies. ANN NEUROL 2017;81:117–128
Approach for fine‐tuning of hybrid dimer antennas via laser melting at the nanoscale
Authors: Sun Yali , Kolodny Stanislav , Lepeshov Sergey , Zuev Dmitry , Huang Lirong , Belov Pavel , Krasnok Alexander 
Published: December 2016

Asymmetric metal‐dielectric nanostructures are demonstrated superior optical properties arising from the combination of strong enhancement of near‐fields and controllable scattering characteristics which originate from plasmonic and high‐index dielectric components. Here, being inspired by the recent advances of the asymmetric hybrid nanoparticles fabrication [Dmitry Zuev, et al., Adv. Mater. 28, 3087 (2016)], we suggest and study numerically a novel type of hybrid dimer nanoantennas. The nanoantennas consist of asymmetric metal‐dielectric (Au/Si) nanoparticles and allow tuning of the near‐ and far‐field properties via laser induced reshaping of the metal part at the nanoscale. We demonstrate an ability to modification of the scattering properties, near‐field distribution profilis, normalized local density of states, and radiation patterns of the nanoantenna upon the laser reshaping. The parameters used to investigate these effects correspond to experimentally demonstrated values.
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