bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single- Versus Multiple-Site Harvesting Techniques for Bone Marrow Concentrate: Evaluation of Aspirate Quality and Pain
Authors: Oliver Kristin , Awan Tariq , Bayes Matthew 
Published: August 2017

Background: Bone marrow concentrate (BMC) is growing in popularity as an alternative treatment option in orthopaedics. The regenerative capacity of BMC has been linked to the number of mesenchymal stem cells (MSCs) present in the graft at the time of its clinical application. MSC counts in bone marrow aspirate (BMA) are affected by harvest technique, but controversy exists over which aspiration method optimizes cellular yield while taking patient comfort and risk into consideration. Purpose: To compare a single- versus multiple-site bone marrow aspiration technique to determine which would generate a sufficient volume of high-quality BMA for concentration into a BMC graft. The level of pain experienced by the patient was monitored, since patient comfort should be included in the determination of a safe and effective aspiration technique. Study Design: Controlled laboratory study and cohort study; Level of evidence, 2. Methods: BMC samples from 6 patients were sent to an outside source for laboratory analysis. All 6 participants underwent bilateral bone marrow aspiration. Each patient received both techniques at the posterior iliac crest: one side underwent a multiple-site aspiration technique, and the contralateral side underwent a single-site technique with needle redirection. BMA and BMC samples were analyzed for concentrations white blood cells, total nucleated cells, red blood cells, neutrophils, and hematopoietic stem cells. One BMC sample was cultured, and MSC analysis was performed via flow cytometry. All patients underwent monitoring of pain scores during and after the procedure through a visual analog pain scale at 24 hours, 72 hours, and 7 days after BMA. Results: No significant difference was found between the cell ratios of the single- and multiple-site groups. Both aspiration techniques were found to provide ample colony-forming units without a marked difference in appearance. Additionally, no significant difference was found between groups with regard to MSC numbers. Pain during and 24 hours after the procedure was significantly greater with the multiple-site method than the single-insertion method. Conclusion: The single-insertion method produced final cellular concentrations and culture results that were not significantly different from those of a multiple-insertion method. Additionally, the single-insertion site technique was significantly less painful to the patient at the time of the procedure as well as 24 hours after aspiration. Clinical Relevance: The results of this study indicated that a high-quality bone marrow aspirate is possible with a single-stick aspiration method.
Six-Month Outcomes for Collaborative Care Management of Depression Among Smoking and Nonsmoking Patients
Authors: Witt Daniel R. , Garrison Gregory M. , Gonzalez Cesar A. , Witt Terrence J. , Angstman Kurt B. 
Published: August 2017

Background: Collaborative care management (CCM) is an evidence-based model that contributes to better outcomes for depression treatment in the primary care setting. Tobacco use increases overall economic costs, morbidity, and mortality and has been shown to impact behavioral health outcomes. Our study aims to observe clinical outcomes for depression treatment for patients with comorbid tobacco use and depression within the CCM model. Methods: A retrospective chart review study of 2826 adult patients with depression enrolled in CCM was performed to determine the association between regular tobacco use and depression outcomes. Baseline intake data consisting of clinical and demographic variables along with 6-month follow-up of Patient Health Questionnaire-9 (PHQ-9) scores for smokers (n = 727, 25.7%) and nonsmokers (n = 2099, 74.3%) were obtained. Depression remission was defined as a PHQ-9 score <5 and persistent depressive symptoms (PDS) as a PHQ-9 score ≥10 at 6 months. Results: Using an intention-to-treat analysis, the multivariate modeling demonstrated that smokers, at 6 months, had an increased adjusted odds ratio (AOR) for PDS: 1.624 (95% CI: 1.353-1.949). Furthermore, smokers had a lower AOR of depression remission: 0.603 (95% CI: 0.492-0.739). Patient adherence to treatment was also lower in smokers with an AOR of 0.666 (95% CI: 0.553-0.802). Conclusions: Smokers enrolled in CCM were associated with reduced treatment adherence and worse outcomes for depression treatment at 6 months compared to nonsmokers, even when baseline clinical and demographic variables were controlled. Thus, new tailored practices may be warranted within the CCM model to treat comorbid depression and tobacco use disorders.
Promising efficacy and acceptable safety of venetoclax plus bortezomib and dexamethasone in relapsed/refractory MM
Authors: Moreau Philippe , Chanan-Khan Asher , Roberts Andrew W. , Agarwal Amit B. , Facon Thierry , Kumar Shaji , Touzeau Cyrille , Punnoose Elizabeth A. , Cordero Jaclyn , Munasinghe Wijith , Jia Jia , Salem Ahmed Hamed , Freise Kevin J. , Leverson Joel D. , Enschede Sari Heitner , Ross Jeremy A. , Maciag Paulo C. , Verdugo Maria , Harrison Simon J. 
Published: August 2017

Key Points
In relapsed/refractory MM, venetoclax plus bortezomib and dexamethasone appears to be safe and efficacious. This is a novel therapeutic approach for MM.
The cross-talk between the kidney and the gut: implications for chronic kidney disease
Authors: de Andrade Laila Santos , Ramos Christiane Ishikawa , Cuppari Lilian 
Published: August 2017

AbstractIn recent decades, special attention has been given to the potential association between the gut ecosystem and chronic diseases. Several features and complications of chronic kidney disease (CKD) may induce an unbalanced gut environment, leading to unfavorable consequences for a patient’s health. The first section of this review is dedicated to a description of some aspects of gut microbiota and intestinal barrier physiology. The following section explores the impact of CKD on the gut ecosystem and intestinal barrier, particularly the association with uremic toxins, inflammation, and immunodeficiency. Finally, the review describes the state of the art of potential therapies with prebiotics, probiotics, and synbiotics employed to modulate the gut environment and to reduce the generation of colon-derived uremic toxins in CKD.
Source-to-sink system and its sedimentary records in the continental rift basins: An example from the Paleogene in the Bohai Sea Area, China
Authors: Xu Changgui , Du Xiaofeng , Zhu Hongtao , Jia Donghui , Xu Wei , Lu Huan 
Published: August 2017

The “source-to-sink” concept originated in the study of global change and atmospheric pollution. In recent years, the concept of a source-to-sink system has been widely applied in continental margin sedimentary analysis. In our research, the idea of source-to-sink is applied to the continental rift basin sedimentary system in the Bohai Sea area. The idea emphasizes that the sedimentation dynamics, including erosion, transportation, and accumulation, are considered as a complete source-to-sink system. The sand-rich region often corresponds to a source-to-sink coupling system in a complex continental rift basin, which includes the effective provenance, high-efficiency routing system, and base-level transition. In addition, (1) the effective provenance can be subdivided into explicit and implicit provenance systems in which the implicit provenance system has been shown to be a significant advancement in reservoir prediction for the Bohai Sea area, (2) the sediment-transport pathways and slope-break zone constitute the routing systems, and (3) the base-level transition is one of the allogenic factors that controls the position of the sandstone distribution in a sequence. Based on a large number of previous studies and different characteristics of sequence-stratigraphic models in the Bohai Sea area, we have evaluated three types of source-to-sink systems, including the fault-steep slope, strike-slip fault slope, and gentle slope pattern. In addition, the fault-steep-slope source-to-sink coupling system can be further subdivided into four types, namely, the corner, relay ramps, fault-throw diminishment-type, and valley-type source-to-sink systems. The source-to-sink system of the gentle slope pattern includes the uplift axis valley-type source-to-sink system and the slope-valley-type source-to-sink system. A small-scale, thick layer of fan delta is formed in the fault-steep-slope zone. A continuous braided river delta is formed in the strike-slip fault slope zone. A large-scale, thin layer of braided river delta is formed in the gentle slope zone. The characteristics of source-to-sink systems in continental rift basins are established for the exploration or prediction of favorable zones in the study area, as well as in similar basins.
Hospitalization Rates and Predictors of Rehospitalization Among Individuals With Advanced Cancer in the Year After Diagnosis
Authors: Whitney Robin L. , Bell Janice F. , Tancredi Daniel J. , Romano Patrick S. , Bold Richard J. , Joseph Jill G. 
Published: August 2017

Purpose Among individuals with advanced cancer, frequent hospitalization increasingly is viewed as a hallmark of poor-quality care. We examined hospitalization rates and individual- and hospital-level predictors of rehospitalization among individuals with advanced cancer in the year after diagnosis. Methods Individuals diagnosed with advanced breast, colorectal, non–small-cell lung, or pancreatic cancer from 2009 to 2012 (N = 25,032) were identified with data from the California Cancer Registry (CCR). After linkage with inpatient discharge data, multistate and log-linear Poisson regression models were used to calculate hospitalization rates and to model rehospitalization in the year after diagnosis, accounting for survival. Results In the year after diagnosis, 71% of individuals with advanced cancer were hospitalized, 16% had three or more hospitalizations, and 64% of hospitalizations originated in the emergency department. Rehospitalization rates were significantly associated with black non-Hispanic (incidence rate ratio [IRR], 1.29; 95% CI, 1.17 to 1.42) and Hispanic (IRR, 1.11; 95% CI, 1.03 to 1.20) race/ethnicity; public insurance (IRR, 1.37; 95% CI, 1.23 to 1.47) and no insurance (IRR, 1.17; 95% CI, 1.02 to 1.35); lower socioeconomic status quintiles (IRRs, 1.09 to 1.29); comorbidities (IRRs, 1.13 to 1.59); and pancreatic (IRR, 2.07; 95% CI, 1.95 to 2.20) and non–small-cell lung (IRR, 1.69; 95% CI, 1.54 to 1.86) cancers versus colorectal cancer. Rehospitalization rates were significantly lower after discharge from a hospital that had an outpatient palliative care program (IRR, 0.90; 95% CI, 0.83 to 0.97) and were higher after discharge from a for-profit hospital (IRR, 1.33; 95% CI, 1.14 to 1.56). Conclusion Individuals with advanced cancer experience a heavy burden of hospitalization in the year after diagnosis. Efforts to reduce hospitalization and provide care congruent with patient preferences might target individuals at higher risk. Future work might explore access to palliative care in the community and related health care use among individuals with advanced cancer.
The constriction and scission machineries involved in mitochondrial fission
Authors: Kraus Felix , Ryan Michael T. 
Published: August 2017

ABSTRACT
A key event in the evolution of eukaryotic cells was the engulfment of an aerobic bacterium by a larger anaerobic archaebacterium, leading to a close relationship between the host and the newly formed endosymbiont. Mitochondria, originating from this event, have evolved to be the main place of cellular ATP production. Maintaining elements of their independence, mitochondria undergo growth and division in the cell, thereby ensuring that new daughter cells inherit a mitochondrial complement. Mitochondrial division is also important for other processes, including quality control, mitochondrial (mt)DNA inheritance, transport and cell death. However, unlike bacterial fission, which uses a dynamin-related protein to constrict the membrane at its inner face, mitochondria use dynamin and dynamin-related proteins to constrict the outer membrane from the cytosolic face. In this Review, we summarize the role of proteins from the dynamin superfamily in mitochondrial division. This includes recent findings highlighting that dynamin-2 (Dnm2) is involved in mitochondrial scission, which led to the reappraisal of the role of dynamin-related protein 1 (Drp1; also known as Dnm1l) and its outer membrane adaptors as components of the mitochondrial constriction machinery along with ER components and actin.
Development of a Coupled Water Quality Model
Authors: Wang Lili , Flanagan Dennis C. , Cherkauer Keith A. 
Published: August 2017

Abstract. . Nonpoint-source (NPS) pollutants, especially from agriculture, continue to be a primary source of waterquality degradation problems. Effective land management decisions at the field scale must be made to minimize nutrient losses that could pollute streams. Existing NPS models often cannot directly estimate the impacts of different land management practices or determine the effectiveness of combined best management practices (BMPs) in a distributed way at the farm scale. In many cases, they rely on application of the Universal Soil Loss Equation (USLE) or its improved versions, which represent fields in a lumped fashion and use empirical rather than process-based modeling methodologies. In this study, a coupled Water Erosion Prediction Project and Water Quality (WEPP-WQ) model was completed, updated, improved, and evaluated for simulation of hydrology, soil erosion, and water quality. The WEPP model is a well-established process-based model that simulates runoff and erosion processes from a hillslope. The water quality components are based on those of the Soil and Water Assessment Tool (SWAT). A single overland flow element (OFE) on a hillslope is used to represent a single soil and land use management. The WEPP-WQ model was tested by comparing simulated values from the coupled model with observed nutrient and sediment concentrations in surface runoff following storm events at experimental sites near Waterloo in northeastern Indiana and at the Throckmorton Purdue Agricultural Center in west central Indiana. Time series evaluation of the WEPP-WQ model was performed with observed nutrient and sediment losses from an experimental plot near Tifton, Georgia. The model performed quite well in simulating nutrient losses for single storm events, with R2 greater than 0.8, Nash-Sutcliffe efficiency (NSE) greater than 0.65, and percent bias (PBIAS) less than 31% for runoff, sediment, nitrate nitrogen, total nitrogen, soluble phosphorus, and total phosphorus losses. In predicting time series nutrient loss, the WEPP-WQ model simulated daily nitrate nitrogen losses adequately, with the ratio of the root mean square error to the standard deviation of measured data (RSR) less than 0.7, NSE greater than 0.55, and PBIAS within the range of ±40%. Comparisons between simulated soluble phosphorus, total phosphorus, and literature results were performed due to the absence of an available observational dataset. The WEPP-WQ model with a single OFE in this study provides a basic but important step for the development of WEPP-WQ models with multiple OFEs that can evaluate the effectiveness of BMPs Keywords: Modeling, Nitrogen, Phosphorus, Soil erosion, Water quality, WEPP.
MOESHA: A Genetic Algorithm for Automatic Calibration and Estimation of Parameter Uncertainty and Sensitivity of Hydrologic Models
Authors: Barnhart Bradley L. , Sawicz Keith A. , Ficklin Darren L. , Whittaker Gerald W. 
Published: August 2017

Abstract. Characterization of the uncertainty and sensitivity of model parameters is an essential facet of hydrologic modeling. This article introduces the multi-objective evolutionary sensitivity handling algorithm (MOESHA) that combines input parameter uncertainty and sensitivity analyses with a genetic algorithm calibration routine to dynamically sample the parameter space. This novel algorithm serves as an alternative to traditional static space-sampling methods, such as stratified sampling or Latin hypercube sampling. In addition to calibrating model parameters to a hydrologic model, MOESHA determines the optimal distribution of model parameters that maximizes model robustness and minimizes error, and the results provide an estimate for model uncertainty due to the uncertainty in model parameters. Subsequently, we compare the model parameter distributions to the distribution of a dummy variable (i.e., a variable that does not affect model output) to differentiate between impactful (i.e., sensitive) and non-impactful parameters. In this way, an optimally calibrated model is produced, and estimations of model uncertainty as well as the relative impact of model parameters on model output (i.e., sensitivity) are determined. A case study using a single-cell hydrologic model (EXP-HYDRO) is used to test the method using river discharge data from the Dee River catchment in Wales. We compare the results of MOESHA with Sobol’s global sensitivity analysis method and demonstrate that the algorithm is able to pinpoint non-impactful parameters, demonstrate the uncertainty of model results with respect to uncertainties in model parameters, and achieve excellent calibration results. A major drawback of the algorithm is that it is computationally expensive; therefore, parallelized methods should be used to reduce the computational burden. Keywords: Genetic algorithm, Hydrologic modeling, Model calibration, Sensitivity analysis, Uncertainty.
Comparative study of the diagnostic and prognostic value of antibodies against chimeric citrullinated synthetic peptides and CCP3/CCP3.1 assays
Authors: Gómara María J. , Rodríguez Javier , Bleda María J. , Salvador Juan P. , Sanmartí Raimon , Haro Isabel 
Published: August 2017

Abstract

Background:
The objective of the study was to compare the diagnostic yield of home-made ELISA tests based on synthetic chimeric fibrin/filaggrin citrullinated peptides (CFFCPs) with CCP3 and CCP3.1 commercial tests to detect anti-citrullinated protein/peptide antibodies (ACPAs) in rheumatoid arthritis (RA) patients. The prognostic value is also studied in a cohort of patients with early RA. Moreover, we transfer immunological assays from microtiter plates to microarray formats to allow the simultaneous analysis of several peptide sequences and reduce the volume of serum from patients.

Methods:
The diagnostic study includes: 100 RA patients who fulfilled the 1987 ACR criteria; 100 healthy blood donors; 35 patients with SLE according ACR criteria; 35 patients with PsA fulfilling the Wright and Moll criteria and 30 patients with HCV infection. The prognostic value study includes 50 patients with early RA with follow-up data available. All samples are from outpatients attending the Rheumatology Department of the Hospital Clinic of Barcelona.

Results:
Similar sensitivity, specificity and predictive values for the diagnosis of RA of CCFCPs compared to CCP3/CCP3.1 were obtained. Although a high concordance is observed between anti-CFFCPs and anti-CCP3/CCP3.1 in the early patients that rendered Larsen radiographic progression, CFFCPs could be a better marker of radiographic outcome. Strong correlations between the microarray and ELISA results were found for individual CFFCPs peptides.

Conclusions:
The development of multiplexing techniques combining a different spectrum of markers in a single analysis, including CFFCP peptides, could allow a more detailed analysis of the autoantibodies reactivity found in the sera of patients suffering of this heterogeneous disease.
Space-Time Petrov–Galerkin FEM for Fractional Diffusion Problems
Authors: Duan Beiping , Jin Bangti , Lazarov Raytcho , Pasciak Joseph , Zhou Zhi 
Published: August 2017

Abstract
We present and analyze a space-time Petrov–Galerkin finite element method for a time-fractional diffusion equation
involving a Riemann–Liouville fractional derivative of order

α
∈

(
0
,
1
)

{\alpha\in(0,1)}

in time and zero initial data.
We derive a proper weak formulation involving different solution and test spaces and show the inf-sup condition for the bilinear form and thus its well-posedness.
Further, we develop a novel finite element formulation, show the well-posedness of the discrete problem, and
derive error bounds in both energy and

L
2

{L^{2}}

norms for the finite element solution. In the proof
of the discrete inf-sup condition, a certain nonstandard

L
2

{L^{2}}

stability property of the

L
2

{L^{2}}

projection operator plays a key role.
We provide extensive numerical examples to verify the convergence analysis.
Efficient Ultra-High Speed Communication with Simultaneous Phase and Amplitude Regenerative Sampling (SPARS)
Authors: Carlowitz Christian , Girg Thomas , Ghaleb Hatem , Du Xuan-Quang 
Published: August 2017

Abstract
For ultra-high speed communication systems at high center frequencies above 100 GHz, we propose a disruptive change in system architecture to address major issues regarding amplifier chains with a large number of amplifier stages. They cause a high noise figure and high power consumption when operating close to the frequency limits of the underlying semiconductor technologies. Instead of scaling a classic homodyne transceiver system, we employ repeated amplification in single-stage amplifiers through positive feedback as well as synthesizer-free self-mixing demodulation at the receiver to simplify the system architecture notably. Since the amplitude and phase information for the emerging oscillation is defined by the input signal and the oscillator is only turned on for a very short time, it can be left unstabilized and thus come without a PLL. As soon as gain is no longer the most prominent issue, relaxed requirements for all the other major components allow reconsidering their implementation concepts to achieve further improvements compared to classic systems. This paper provides the first comprehensive overview of all major design aspects that need to be addressed upon realizing a SPARS-based transceiver. At system level, we show how to achieve high data rates and a noise performance comparable to classic systems, backed by scaled demonstrator experiments. Regarding the transmitter, design considerations for efficient quadrature modulation are discussed. For the frontend components that replace PA and LNA amplifier chains, implementation techniques for regenerative sampling circuits based on super-regenerative oscillators are presented. Finally, an analog-to-digital converter with outstanding performance and complete interfaces both to the analog baseband as well as to the digital side completes the set of building blocks for efficient ultra-high speed communication.