bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adequacy of Malignant Pleural Effusion for Epidermal Growth Factor Receptor Mutation Analysis Using the Pyrosequencing Method
Authors: Hatoum Hassan , Lourdes Ylagan , Dhillon Samjot S. , Dy Grace K. , Attwood Kristopher , Pokuri Venkata , Harris Kassem 
Published: November 2015

Background: Epidermal growth factor receptor (EGFR) mutation analysis is a standard approach for initial therapeutic decision in patients with metastatic adenocarcinoma of the lung (MAL). The feasibility of performing EGFR mutation testing using pleural fluid specimen is not well characterized. Objectives: The aim of this study is to report the percentage of patients eligible for EGFR mutation testing based on the percentage of malignant cells (PMCs) in the pleural fluid using the pyrosequencing method. Methods: From our database, we reviewed the clinical data of 61 patients with malignant pleural effusion (MPE) secondary to MAL. The PMCs were divided into 2 categories with a cutoff point of 10% (PMC1 is defined as ≤10% and PMC2 is defined as >10%). For the pyrosequencing method, only patients in the PMC2 group were eligible for EGFR mutation testing. Results: Of 61 patients with MPE secondary to MAL, 38 (62.3%) were in the PMC2 group, which represents the percentage of patients eligible for EGFR mutation testing. Of these 38 patients, 15 patients had the testing done on the MPE. Quantity was not sufficient for testing only in 1 patient. Therefore, in PMC2 patients group, the rate of successful EGFR mutation testing was 93% (14 of 15). The thoracentesis volume was not significantly different between PMC1 and PMC2. Conclusion: Performing EGFR mutation analysis on the MPE in patients with MAL is feasible in 62% of patients. The rate of successful testing on the eligible samples is 93%.
Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia
Authors: Karol Seth E. , Mattano Leonard A. , Yang Wenjian , Maloney Kelly W. , Smith Colton , Liu ChengCheng , Ramsey Laura B. , Fernandez Christian A. , Chang Tamara Y. , Neale Geoffrey , Cheng Cheng , Mardis Elaine , Fulton Robert , Scheet Paul , San Lucas F. Anthony , Larsen Eric C. , Loh Mignon L. , Raetz Elizabeth A. , Hunger Stephen P. , Devidas Meenakshi , Relling Mary V. 
Published: November 2015

Key PointsVariants in genes important for mesenchymal stem cell differentiation influence the risk of osteonecrosis in children with ALL under 10 years old. Variants in genes in the glutamate signaling pathway influence osteonecrosis in children with ALL regardless of age.
Non-convex hybrid algorithm for a family of countable quasi-Lipschitz mappings and application
Authors: Guan Jinyu , Tang Yanxia , Ma Pengcheng , Xu Yongchun , Su Yongfu 
Published: November 2015

AbstractThe purpose of this article is to establish a kind of non-convex hybrid iteration algorithms and to prove relevant strong convergence theorems of common fixed points for a uniformly closed asymptotically family of countable quasi-Lipschitz mappings in Hilbert spaces. Meanwhile, the main result is applied to get the common fixed points of finite family of quasi-asymptotically nonexpansive mappings. It is worth pointing out that a non-convex hybrid iteration algorithm is first presented in this article, a new technique is applied in our process of proof. Finally, an example is given which is a uniformly closed asymptotically family of countable quasi-Lipschitz mappings. The results presented in this article are interesting extensions of some current results.
WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts
Authors: Malinova Dessislava , Fritzsche Marco , Nowosad Carla R , Armer Hannah , Munro Peter M G , Blundell Michael P , Charras Guillaume , Tolar Pavel , Bouma Gerben , Thrasher Adrian J 
Published: November 2015

Abstract
The immunological synapse is a highly structured and molecularly dynamic interface between communicating immune cells. Although the immunological synapse promotes T cell activation by dendritic cells, the specific organization of the immunological synapse on the dendritic cell side in response to T cell engagement is largely unknown. In this study, confocal and electron microscopy techniques were used to investigate the role of dendritic cell actin regulation in immunological synapse formation, stabilization, and function. In the dendritic cell-restricted absence of the Wiskott-Aldrich syndrome protein, an important regulator of the actin cytoskeleton in hematopoietic cells, the immunological synapse contact with T cells occupied a significantly reduced surface area. At a molecular level, the actin network localized to the immunological synapse exhibited reduced stability, in particular, of the actin-related protein-2/3-dependent, short-filament network. This was associated with decreased polarization of dendritic cell-associated ICAM-1 and MHC class II, which was partially dependent on Wiskott-Aldrich syndrome protein phosphorylation. With the use of supported planar lipid bilayers incorporating anti-ICAM-1 and anti-MHC class II antibodies, the dendritic cell actin cytoskeleton organized into recognizable synaptic structures but interestingly, formed Wiskott-Aldrich syndrome protein-dependent podosomes within this area. These findings demonstrate that intrinsic dendritic cell cytoskeletal remodeling is a key regulatory component of normal immunological synapse formation, likely through consolidation of adhesive interaction and modulation of immunological synapse stability.
Effect of bacillus Calmette-Guérin vaccination on CD4+Foxp3+ T cells during acquired immune response to Mycobacterium tuberculosis infection
Authors: Henao-Tamayo Marcela I , Obregón-Henao Andres , Arnett Kimberly , Shanley Crystal A , Podell Brendan , Orme Ian M , Ordway Diane J 
Published: November 2015

Abstract
Increasing information has shown that many newly emerging strains of Mycobacterium tuberculosis, including the highly prevalent and troublesome Beijing family of strains, can potently induce the emergence of Foxp3+ CD4 Tregs. Although the significance of this is still not fully understood, we have previously provided evidence that the emergence of this population can significantly ablate the protective effect of BCG vaccination, causing progressive fatal disease in the mouse model. However, whether the purpose of this response is to control inflammation or to directly dampen the acquired immune response is still unclear. In the present study, we have shown, using both cell depletion and adoptive transfer strategies, that Tregs can have either properties. Cell depletion resulted in a rapid, but transient, decrease in the lung bacterial load, suggesting release or temporary re-expansion of effector immunity. Transfer of Tregs into Rag2−/− or marked congenic mice worsened the disease course and depressed cellular influx of effector T cells into the lungs. Tregs from infected donors seemed to preferentially depress the inflammatory response and granulocytic influx. In contrast, those from BCG-vaccinated and then challenged donors seemed more focused on depression of acquired immunity. These qualitative differences might be related to increasing knowledge reflecting the plasticity of the Treg response.
Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study
Authors: Harrigan Maura , Cartmel Brenda , Loftfield Erikka , Sanft Tara , Chagpar Anees B. , Zhou Yang , Playdon Mary , Li Fangyong , Irwin Melinda L. 
Published: November 2015

Purpose Obesity is associated with a higher risk of breast cancer mortality. The gold standard approach to weight loss is in-person counseling, but telephone counseling may be more feasible. We examined the effect of in-person versus telephone weight loss counseling versus usual care on 6-month changes in body composition, physical activity, diet, and serum biomarkers. Methods One hundred breast cancer survivors with a body mass index ≥ 25 kg/m2 were randomly assigned to in-person counseling (n = 33), telephone counseling (n = 34), or usual care (UC) (n = 33). In-person and telephone counseling included 11 30-minute counseling sessions over 6 months. These focused on reducing caloric intake, increasing physical activity, and behavioral therapy. Body composition, physical activity, diet, and serum biomarkers were measured at baseline and 6 months. Results The mean age of participants was 59 ± 7.5 years old, with a mean BMI of 33.1 ± 6.6 kg/m2, and the mean time from diagnosis was 2.9 ± 2.1 years. Fifty-one percent of the participants had stage I breast cancer. Average 6-month weight loss was 6.4%, 5.4%, and 2.0% for in-person, telephone, and UC groups, respectively (P = .004, P = .009, and P = .46 comparing in-person with UC, telephone with UC, and in-person with telephone, respectively). A significant 30% decrease in C-reactive protein levels was observed among women randomly assigned to the combined weight loss intervention groups compared with a 1% decrease among women randomly assigned to UC (P = .05). Conclusion Both in-person and telephone counseling were effective weight loss strategies, with favorable effects on C-reactive protein levels. Our findings may help guide the incorporation of weight loss counseling into breast cancer treatment and care.
Anastrozole-Induced Carpal Tunnel Syndrome: Results From the International Breast Cancer Intervention Study II Prevention Trial
Authors: Spagnolo Francesco , Sestak Ivana , Howell Anthony , Forbes John F. , Cuzick Jack 
Published: November 2015

Purpose Carpal tunnel syndrome (CTS) occurs when the median nerve is compressed at the wrist in the carpal tunnel. It has been suggested that hormonal risk factors may be involved in the pathogenesis of CTS, and a higher incidence of CTS has been reported in randomized clinical trials with aromatase inhibitors (AIs) compared with tamoxifen. Patients and Methods This was an exploratory analysis of the International Breast Cancer Intervention Study II, a double-blind randomized clinical trial in which women at increased risk of breast cancer were randomly assigned to receive anastrozole or placebo. This is the first report of risk factors for and characteristics of CTS in women taking an AI in a placebo-controlled trial. Results Overall, 96 participants with CTS were observed: 65 (3.4%) in the anastrozole arm and 31 (1.6%) in the placebo arm (odds ratio, 2.16 [1.40 to 3.33]; P < .001). Ten participants were reported as having severe CTS, of which eight were taking anastrozole (P = .08). Eighteen women (0.9%) in the anastrozole arm and six women (0.3%) in the placebo arm reported surgical intervention, which was significantly different (odds ratio, 3.06 [1.21 to 7.72], P = .018). Six women discontinued with the allocated treatment because of the onset of CTS. Apart from treatment allocation, a high body mass index and an a prior report of musculoskeletal symptoms after trial entry were the only other risk factors for CTS identified in these postmenopausal women. Conclusions The use of anastrozole was associated with a higher incidence of CTS but few participants required surgery. Further investigations are warranted into the risk factors and treatment of AI-induced CTS.
Psychological Safety Development Drill As a Mean of Training First-Year Students for Educational Practice
Authors: Столярова  , Stolyarova E. 
Published: November 2015

In article experimentally substantiates the efficiency of
psychological safety training in education for training first-year
students, future bachelors of psychology and pedagogy programs.
It reveals prospective of the training that provide preparation for
recognising and overcoming psychological dangers arising towards
an individual himself or towards subjects of interaction during
educational practice.
Matching Platforms and HIV Incidence: An Empirical Investigation of Race, Gender, and Socioeconomic Status
Authors: Greenwood Brad N. , Agarwal Ritu 
Published: November 2015

Although recent work has examined the adverse implications of Internet-enabled matching platforms, limited attention has been paid to whom the negative externalities accrue. We examine how the entry of platforms for the solicitation of casual sex influences the incidence rate of human immunodeficiency virus (HIV) infection by race, gender, and socioeconomic status. Using a census of 12 million patients subjected to a natural experiment in Florida, we find a significant increase in HIV incidence after platform implementation, with the largest effect accruing to historically at-risk populations (i.e., African Americans) despite documented lower rates of Internet utilization. Strikingly, our analysis reveals that HIV incidence increases in historically low-risk populations as well (e.g., individuals of higher socioeconomic status) and that men and women experience similar penalties. Identifying granular effects across subpopulations allows us to offer additional insight into the mechanisms by which matching platforms increase HIV incidence. We estimate the cumulative effect of platform entry over the five-year period of the study as 1,149 additional Floridians contracting HIV at a cost of $710 million. This paper was accepted by Lorin Hitt, information systems.
Market Design and Moral Behavior
Authors: Kirchler Michael , Huber Jürgen , Stefan Matthias , Sutter Matthias 
Published: November 2015

In an experiment with 739 subjects, we study whether and how different interventions might have an influence on the degree of moral behavior when subjects make decisions that can generate negative externalities on uninvolved parties. Particularly, subjects can either take money for themselves or donate it to UNICEF for measles vaccines. By considering two fairly different institutional regimes—one with individual decision making, one with a double-auction market—we expose the different interventions to a kind of robustness check. We find that the threat of monetary punishment promotes moral behavior in both regimes. Getting subjects more involved with the traded good has no effect, though, in both regimes. Only the removal of anonymity, thus making subjects identifiable, has different effects across regimes, which we explain by different perceptions of responsibility. This paper was accepted by Uri Gneezy, behavioral economics.
The sky is the limit: Feng Xiaonings leitmotif cinema, Chinese soft power and ideological fantasy
Authors: Green Frederik H. 
Published: November 2015

Abstract
This article explores the intersection of politics and popular entertainment in contemporary Chinese leitmotif cinema (zhuxuanlü dianying), a genre that conflates political didacticism with Hollywood-style entertainment. Through my reading of three movies by Feng Xiaoning (馮小寧) – the hero-epos Qingzang xian/A Railway in the Clouds (2006) about the building of a rail link to Tibet; the disaster movie Chaoqiang taifeng/Super Typhoon (2008), about a Chinese metropolis hit by a storm; and the war-action drama Jiawu dahaizhan/Naval Battle (2012), about the Sino-Japanese naval conflict of 1895 – I will illustrate how leitmotif cinema negotiates demands for doctrinal orthodoxy with expectations for box office success. Feng’s cinematic aesthetics are thus symptomatic of the discursive complexity of post-socialist Chinese cinema where multiple temporalities and modes of production coexist in a climate of state-enforced ideological hegemony and revenue-driven market economics.
Dont mention (them) again! Shame, the Black Eagles Incident and Winds of September
Authors: Chen Po-hsi 
Published: November 2015

Abstract
The 1997 Black Eagles Incident of the Chinese Professional Baseball League (CPBL) marks the Edenic fall in the history of baseball in Taiwan. Since the Black Eagles Incident, the nationalist discourse of glory had been intertwined with the narrative of shame. Having been immersed in the spirit of triumphalism in the early 2000s, baseball in Taiwan was again beset by a series of large-scale game-fixing scandals in the latter half of the 2000s. The neologism mozaiti  dont mention again  was coined as a response by desperate fans. This article reads Lin Shu-yus 2008 film Jiujiang feng/Winds of September, a baseball story of initiation and disillusion featuring a former professional baseball players cameo appearance, against this backdrop. The film visually frames a phantasmatic space in which the not-to-be-mentioned fallen hero is staged to perform his failure and guilt. In so doing, his affect of shame is exchanged with his fans through that cinematically imagined, constructed phantasmatic space. In this sense, the image of baseball in the post-martial-law era is internalized within ones adolescence and familial (especially father-and-son) relationship. In Winds of September, ones faulted youth and troubled family ties are reconciled through coming to terms with the baseball scandal.
Luxury fashion flagship hotels and cultural opportunism: The cases of Hotel Missoni Edinburgh and Maison Moschino
Authors: Dallabona Alice 
Published: November 2015

Abstract
This article gives an insight into the phenomenon of brand extension into the hospitality business by Italian luxury fashion labels and conceptualizes it in terms of luxury fashion flagship hotels. Examining the cases of Hotel Missoni Edinburgh and Maison Moschino this article investigates the different ways in which they refer to Italy and its culture. It is argued that within Hotel Missoni Edinburgh and Maison Moschino there are strategies of cultural opportunism at play that are aimed at deploying their Italianicity as a means to strengthen their association with their parent brands and increase their prestige, but also to augment their offerings, maximizing the brand extension potential of those labels. Through a semiotic analysis, it is contended that Hotel Missoni Edinburgh and Maison Moschino capitalize not only on parent brands Missoni and Moschino but also on the positive connotations associated with Italy and its lifestyle, so that they can convey meanings that concern a broader sociocultural context and that revolve around issues of national identity. The hotels portray versions of Italianicity based on different traits but both contribute to the creation of a myth of Italy that involves the commodification of the Italian national identity and promotes its symbolic consumption.
Expressive labour and the gift of hospitality
Authors: Poulston Jill 
Published: November 2015

Abstract
The phenomenon of hospitality is difficult to understand and define, perhaps because of the transactional nature that pervades what is essentially a moral duty, but also, because of the multifaceted nature of commercial hospitality. While it is useful to separate the philosophical and functional aspects of hospitality, this study explores the potential for these to coexist in the feelings of hospitality providers about their work. Experiences of hospitality service are recorded and the motives and rewards for hospitality work explored using a phenomenological approach. Paid hospitality work is portrayed as distinct from normal reality, and experienced as a love–hate relationship with an addictive quality. The study finds that motives for providing both commercial and private hospitality are primarily intrinsic, as server-hosts seek pleasure by providing pleasure to others. The article concludes by proposing that providers of hospitality experience their roles as a form of self-expression, which motivates them to persevere, often enduring difficult working conditions.
The wager of political hospitality: Introduction to themed articles
Authors: Boudou Benjamin 
Published: November 2015

Abstract
In this article I present a political analysis of hospitality, underlining the power relations that are involved with its practice. Because hospitality is consubstantial with boundaries, it is an apparatus both to welcome and control, which allows the passage of outsiders while legitimating the separation between inside and outside. Thus, the philosophical debate surrounding hospitality appears less relevant than the evaluation of the reasons why it matters to choose policies that involve hospitality. This wager maintains that inclusion – and participation of those included – is the bedrock of both hospitality and democracy.
Spain’s Mortgage Victims Platform (PAH) as a case of a hospitality social movement
Authors: Sanjaume-Calvet Marc 
Published: November 2015

Abstract
In this article I analyse the Plataforma de Afectados por la Hipoteca (PAH) social movement in Spain through the concept of hospitality. In doing so, I develop a double hypothesis concerning the PAH. First, I consider the possibility of the PAH social movement as a public outcry of the ethics and politics of hospitality. Second, I identify a type of disobedient hospitality, practised by the PAH, which defies the legality enforced by dominant discourse. As a hospitality movement, the PAH promotes illegal hospitality based on civil disobedience and exploits the unconditional and conditional tensions within the idea of hospitality. I conclude that the activism of this social movement creates the possibility of a socialized and politicized hospitality that expands beyond its traditional private interpersonal sphere. I claim that in the future these concepts (basically hospitality as a movement) can be explored in other domains and political practices of social movements claiming rights and empowerment such as workers, immigration, gender or LGTB groups.
Dark hospitality: Hotels as places for the end of life
Authors: Hay Brian 
Published: November 2015

Abstract
This article explores through the concept of dark hospitality why some people choose to die in a hotel, rather than at home, in a hospice or a hospital. Through in-depth interviews with hotel managers and junior staff at four luxury city hotels, this issue was explored from the perspective of ordinary hotel guests, all of whom had a longterm relationship with the hotel where they died. The hotel staff suggested that the reasons why some people choose to die in a hotel include loneliness, fear and minimizing emotional distress for their friends and relatives. The impact of managing such guests is also investigated and the results suggest that although managers do care about the impact on the reputation of the hotel, they, along with their staff, are very much affected emotionally by these types of planned deaths. The suggestion emerged from the interviews that with an increasing ageing population, perhaps in the not-too-distant future, the ‘hospice hotel’ could emerge as a new commercial hospitality product.