bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries
Authors: Le Luong , Duckles Hayley , Schenkel Torsten , Mahmoud Marwa , Tremoleda Jordi , Wylezinska-Arridge Marzena , Ali Majid , Bowden Neil , Villa-Uriol Mari-Cruz , Van der Heiden Kim , Xing Ruoyu , Gijsen Frank , Wentzel Jolanda , Lawrie Allan , Feng Shuang , Arnold Nadine , Gsell Willy , Lungu Angela , Hose Rodney , Spencer Tim , Halliday Ian , Ridger Victoria , Evans Paul 
Published: April 2016

SummaryBlood flow generates wall shear stress (WSS) which alters endothelial cell (EC) function. Low WSS promotes vascular inflammation and atherosclerosis whereas high uniform WSS is protective. Ivabradine decreases heart rate leading to altered haemodynamics. Besides its cardio-protective effects, ivabradine protects arteries from inflammation and atherosclerosis via unknown mechanisms. We hypothesised that ivabradine protects arteries by increasing WSS to reduce vascular inflammation. Hypercholesterolaemic mice were treated with ivabradine for seven weeks in drinking water or remained untreated as a control. En face immunostaining demonstrated that treatment with ivabradine reduced the expression of pro-inflammatory VCAM-1 (p<0.01) and enhanced the expression of anti-inflammatory eNOS (p<0.01) at the inner curvature of the aorta. We concluded that ivabradine alters EC physiology indirectly via modulation of flow because treatment with ivabradine had no effect in ligated carotid arteries in vivo, and did not influence the basal or TNFα-induced expression of inflammatory (VCAM-1, MCP-1) or protective (eNOS, HMOX1, KLF2, KLF4) genes in cultured EC. We therefore considered whether ivabradine can alter WSS which is a regulator of EC inflammatory activation. Computational fluid dynamics demonstrated that ivabradine treatment reduced heart rate by 20 % and enhanced WSS in the aorta. In conclusion, ivabradine treatment altered haemodynamics in the murine aorta by increasing the magnitude of shear stress. This was accompanied by induction of eNOS and suppression of VCAM-1, whereas ivabradine did not alter EC that could not respond to flow. Thus ivabradine protects arteries by altering local mechanical conditions to trigger an anti-inflammatory response.
Irregular Shape of Intracranial Aneurysm Indicates Rupture Risk Irrespective of Size in a Population-Based Cohort
Authors: Lindgren Antti E. , Koivisto Timo , Björkman Joel , von und zu Fraunberg Mikael , Helin Katariina , Jääskeläinen Juha E. , Frösen Juhana 
Published: April 2016

Background and Purpose—
Size and shape of saccular intracranial aneurysms (sIA) reflect the condition of the sIA wall and were risk factors for rupture in previous follow-up studies. We investigated how well size or shape identify rupture-prone sIAs.

Methods—
In a population-based registry, we investigated the characteristics of ruptured sIAs treated in a single neurosurgical center (1980–2014). In addition to univariate analysis, logistic regression was used in multivariate analysis, and sensitivity and specificity of size or shape were calculated using receiver operating characteristic curves.

Results—

Ruptured sIAs were on average larger than unruptured sIAs (median, 7 versus 4 mm;
P
<0.000), but location and patient background affected the size at rupture. Of the ruptured sIAs, 38% were smaller than 7 mm and 18% were smaller than 4 mm. Of those sIAs that had ruptured at a small (<7 mm) size, 87% had an irregular shape. In multivariate analysis, irregular shape had the strongest association with presentation as ruptured sIA (odds ratio, 7.1; 95% confidence interval, 6.0–8.3), with better sensitivity (91%) and specificity (76%), in contrast to smoking (odds ratio, 0.7; 95% confidence interval, 0.6–0.9; sensitivity, 28%; specificity 57%) and Population, Hypertension, Age, Size of sIA, Earlier SAH from another sIA, Site of sIA score (odds ratio, 1.5; 95% confidence interval, 1.4–1.6).

Conclusions—
Irregular or multilobular shape is strongly associated with rupture in sIAs of all sizes and independent of location and patient background. Especially sIAs with irregular shape should be considered as high rupture risk lesions, even if small in diameter and in nonsmoking patients with low PHASES scores.
Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia
Authors: Pase Matthew P. , Beiser Alexa , Enserro Danielle , Xanthakis Vanessa , Aparicio Hugo , Satizabal Claudia L. , Himali Jayandra J. , Kase Carlos S. , Vasan Ramachandran S. , DeCarli Charles , Seshadri Sudha 
Published: April 2016

Background and Purpose—
The American Heart Association developed the ideal cardiovascular health (CVH) index as a simple tool to promote CVH; yet, its association with brain atrophy and dementia remains unexamined.

Methods—
Our aim was to investigate the prospective association of ideal CVH with vascular brain injury, including the 10-year risks of incident stroke and dementia, as well as cognitive decline and brain atrophy on magnetic resonance imaging, measured for ≈7 years. We studied 2750 stroke- and dementia-free Framingham Heart Study Offspring cohort participants (mean age, 62±9 years; 45% men). Ideal CVH was quantified on a 7-point scale with 1 point awarded for each of the following: nonsmoking status, ideal body mass index, regular physical activity, healthy diet, as well as optimum blood pressure, cholesterol, and fasting blood glucose. Both recent (baseline) and remote (6.9 years earlier) ideal CVH scores were examined.

Results—

Recent ideal CVH was associated with stroke (hazard ratio, 0.80; 95% confidence interval, 0.67–0.95), vascular dementia (hazard ratio, 0.49; 95% confidence interval, 0.30–0.81), frontal brain atrophy (
P
=0.003), and cognitive decline on tasks measuring visual memory and reasoning (
P
<0.05). In addition to predicting stroke, vascular dementia, whole-brain atrophy, and cognitive decline, remote ideal CVH was associated with the incidence of all-cause dementia (hazard ratio, 0.80; 95% confidence interval, 0.67–0.97) and Alzheimer disease (hazard ratio, 0.79; 95% confidence interval, 0.64–0.98).

Conclusions—
Adherence to the American Heart Association’s ideal CVH factors and behaviors, particularly in midlife, may protect against cerebrovascular disease and dementia.
Short-Term Probabilistic Forecasts of the 31 May 2013 Oklahoma Tornado and Flash Flood Event Using a Continuous-Update-Cycle Storm-Scale Ensemble System
Authors: Yussouf Nusrat , Kain John S. , Clark Adam J. 
Published: April 2016

AbstractA continuous-update-cycle storm-scale ensemble data assimilation (DA) and prediction system using the ARW model and DART software is used to generate retrospective 0–6-h ensemble forecasts of the 31 May 2013 tornado and flash flood event over central Oklahoma, with a focus on the prediction of heavy rainfall. Results indicate that the model-predicted probabilities of strong low-level mesocyclones correspond well with the locations of observed mesocyclones and with the observed damage track. The ensemble-mean quantitative precipitation forecast (QPF) from the radar DA experiments match NCEP’s stage IV analyses reasonably well in terms of location and amount of rainfall, particularly during the 0–3-h forecast period. In contrast, significant displacement errors and lower rainfall totals are evident in a control experiment that withholds radar data during the DA. The ensemble-derived probabilistic QPF (PQPF) from the radar DA experiment is more skillful than the PQPF from the no_radar experiment, based on visual inspection and probabilistic verification metrics. A novel object-based storm-tracking algorithm provides additional insight, suggesting that explicit assimilation and 1–2-h prediction of the dominant supercell is remarkably skillful in the radar experiment. The skill in both experiments is substantially higher during the 0–3-h forecast period than in the 3–6-h period. Furthermore, the difference in skill between the two forecasts decreases sharply during the latter period, indicating that the impact of radar DA is greatest during early forecast hours. Overall, the results demonstrate the potential for a frequently updated, high-resolution ensemble system to extend probabilistic low-level mesocyclone and flash flood forecast lead times and improve accuracy of convective precipitation nowcasting.
Geometrical and mechanical modelings of dry relaxed slack plain-knitted fabrics for the benefit of technical textile applications Part I: a geometrical model
Authors: Kurbak Arif 
Published: April 2016

In the current literature, there is a lack of knowledge concerning which parameters are effective on relaxed slack plain-knitted conventional fabrics, although slack fabrics (i.e. fabrics with no occurrence of jamming) are commonly used for technical applications. Thus, the present series of works are conducted as further investigation on relaxed slack plain-knitted fabrics. In the present part, Part I, a geometrical model is created based on Kurbak's 1998 model. The created model is then applied to conventional dry, wet and wash relaxed wool plain-knitted slack fabrics. The model is also applied to E-glass dry relaxed technical plain-knitted slack fabric. The applied models are then drawn to scale by using 3DS-Max computer graphical software. At first glance, the loop shapes obtained through the three-dimensional modeling of E-glass fabrics are observed to be similar to the E-glass fabric loops that were recorded in the photographs of the knitted samples. An investigation on the physical conditions for obtaining such a special loop shape is going to be the subject of the following part, Part II.
First Dutch guidelines on lipedema using the international classification of functioning, disability and health
Authors: Halk Anne B , Damstra Robert J 
Published: April 2016

Introduction Lipedema is a chronic, progressive condition that can result in considerable disability. In 2011, the Dutch Society of Dermatology and Venereology organized a task force to create guidelines on lipedema, using the International Classification of Functioning, Disability and Health of the World Health Organization. Guideline development Clinical questions on significant issues in lipedema care were proposed, involving (1) making the diagnosis of lipedema; (2) clinimetric measurements for early detection and adequate follow-up; and (3) treatment. A systematic review of literature published up to June 2013 was conducted. Based on available evidence and experience of the task force, answers were formed and recommendations were stated. The guidelines define criteria to make a medical diagnosis of lipedema, a minimum data set of (repeated) clinical measurements that should be used to ensure early detection and an individually outlined follow-up plan, pillars on which conservative treatment should be based and recommendations on surgical treatment options. Conclusions Little consistent information concerning either diagnostics or therapy can be found in the literature. It is likely that lipedema is frequently misdiagnosed or wrongly diagnosed as only an aesthetic problem and therefore under- or mis-treated. Treatment is divided into conservative and chirurgic treatment. The only available technique to correct the abnormal adipose tissue is surgery. Recommendations To ensure early detection and an individually outlined follow-up, the committee advises the use of a minimum data set of (repeated) measurements of waist circumference, circumference of involved limbs, body mass index and scoring of the level of daily practice and psychosocial distress. Promotion of a healthy lifestyle with individually adjusted weight control measures, graded activity training programs, edema reduction, and other supportive measures are pillars of conservative therapy. Tumescent liposuction is the treatment of choice for patients with a suitable health profile and/or inadequate response to conservative and supportive measures.
Estimating Demand Using Space Elastic Demand Model for Retail Assortment Planning
Authors: Singh Alok Kumar , Kapoor Rohit 
Published: April 2016

A retailer assortment is defined as a mix of products stocked in a retail store. The identification of proper assortment has become difficult in the current consumer-centric environment. Assortment planning (AP) in a retail chain largely depends on the estimation of demand of various products under consideration. The knowledge of the true demand rates and substitution rates is important for a retailer for a variety of management decisions, such as the ideal assortment to carry, the quantum of each item to be stocked and how often to replenish the stock (Anupindi, Dada & Gupta, 1998). Space elastic demand model is one of the models which have been widely used for demand estimation in retail AP literature. However, there is paucity of empirical studies in this field of research. In this article, the demand has been estimated using space elastic demand model for two product categories comprising 11 products within the category. The study illustrates the methodology for estimation of demand using space elastic demand model. The results obtained are consistent with the results obtained in few of the empirical studies done in other contexts.
Building Simulation Game-Based Teaching Program for Secondary School Students
Authors: Wardaszko Marcin 
Published: April 2016

Background.Business simulations are being played by a growing number of students. One potential scope for their implementation is the introduction of game-based programs at an early stage of the education ladder. Teaching programs with computer-aided simulations are new tools addressed to both secondary school teachers and students. Aim. This article describes a secondary school program supported by a business simulation game. The program was designed to teach students fundamental knowledge in the fields of economics and business. Methodology. The article gives insight into the design process and the final product of this teaching and learning program. Demand modeling, econometric decision modeling sample, insights into game scenario design, and the teaching program material offer a broad picture of the scope and nature of this project. Results and Recommendations. The project illustrates the process of educational game design in a setting of many limitations. Application of user-centered design and flow methodologies was helpful in designing and implementing this game into a teaching program for secondary school students. The students benefit from an optimal experience owing to a goal-oriented, evolutionary model of demand and costs developed for the purpose of implementation of the project.
A significant decrease in diagnosis of primary progressive multiple sclerosis: A cohort study
Authors: Westerlind Helga , Stawiarz Leszek , Fink Katharina , Hillert Jan , Manouchehrinia Ali 
Published: April 2016

Background: Several reports indicate changes to prevalence, incidence, female-to-male ratio in multiple sclerosis. Diagnostic criteria, course definitions and clinical management of the disease have also undergone change during the recent decades. Objective: To investigate temporal trends in the diagnosis of primary progressive multiple sclerosis (PPMS) in Sweden. Methods: Through the Swedish MS registry we investigated the proportion of PPMS diagnosis in birth, diagnosis and age period cohorts using Poisson regression. Results: A total of 16,915 patients were categorised into six birth-cohorts from 1946 to 1975 and seven date-of-diagnosis-cohorts from 1980 to 2014. We observed a decrease in the uncorrected analysis of diagnosis of PPMS from 19.2% to 2.2% and an average decrease of 23% ( p < 0.001) per 5-year birth-cohort in the adjusted analysis. An average 21% ( p < 0.001) decrease per diagnosis-cohort was seen. In the age-specific diagnosis period cohorts the same decreasing trend of PPMS diagnosis was observed in almost all groups. Conclusion: The diagnosis of PPMS has significantly decreased in Sweden specifically after introduction of disease-modifying treatments. Such decrease can have severe impacts on the future research on PPMS. Our data also suggest that the current trend to emphasise presence or absence of inflammatory activity is already reflected in clinical practice.
Losing touch – Teachers’ self-regulation in physical education
Authors: Öhman Marie 
Published: April 2016

The question of physical interaction is especially relevant in school physical education, where a lot of the teaching and activities are based on body movements. However, the issue of ‘touching’ has been questioned in recent years. This paper takes its starting point in the discourse of child protection and the growing anxiety around intergenerational touch in educational settings. The purpose is to examine PE teachers’ self-regulation in relation to the child protection discourse and no touch policies. What sort of strategies have the teachers developed for dealing with physical contact in their teaching? It is a matter of problematising teachers’ pedagogical interactions in PE practice. The study takes its starting point in a discourse-analytical tradition using a methodology based on Foucault’s ideas about governmentality. Twenty-three teachers (10 women and 13 men) aged 30–63 and at different stages in their careers were interviewed. The results show two different self-regulating processes: (1) adaptation using avoidance-oriented strategies and (2) resistance using downplaying-oriented strategies. The paper discusses potential consequences for PE teachers’ pedagogical work if they feel that they have to protect themselves instead of operating in a way that is in the best interest for students’ learning and development. The study aims to contribute to the literature on child protection and ‘no touch’ policies and to a more multifaceted understanding of physical interaction in PE.
The Potential (F)utility of a Passive Organ Donor Registration Opportunity
Authors: Siegel Jason T. , Alvaro Eusebio M. , Tan Cara N. , Navarro Mario A. , Garner Lori R. , Jones Sara Pace 
Published: April 2016

Context: Approximately 22 people die each day in the United States as a result of the shortage of transplantable organs. This is particularly problematic among Spanish-dominant Hispanics. Increasing the number of registered organ donors can reduce this deficit. Objective: The goal of the current set of studies was to conceptually replicate a prior study indicating the lack of utility of a lone, immediate and complete registration opportunity (ICRO). Design and Setting: The study, a quasi-experimental design involving a total of 4 waves of data collection, was conducted in 2 different Mexican consulates in the United States. Guided by the IIFF Model (ie, an ICRO, information, focused engagement, and favorable activation), each wave compared a lone ICRO to a condition that likewise included an ICRO but also included the 3 additional intervention components recommended by the model (ie, information, focused engagement, and favorable activation). Participants: Visitors to the Mexican consulates in Tucson, Arizona, and Albuquerque, New Mexico, constituted the participant pool. Main Outcome Measure: New organ donor registrations represented the dependent variable. Results: When all 4 components of the IIFF Model were present, approximately 4 registrations per day were recorded; the lone ICRO resulted in approximately 1 registration every 15 days. Conclusion: An ICRO, without the other components of the IIFF Model, is of minimal use in regard to garnering organ donor registrations. Future studies should use the IIFF Model to consider how the utility of ICROs can be maximized.
Evidence for an Environmental and Inherited Predisposition Contributing to the Risk for Global Tendinopathies or Compression Neuropathies in Patients With Rotator Cuff Tears
Authors: Tashjian Robert Z. , Farnham James M. , Granger Erin K. , Teerlink Craig C. , Cannon-Albright Lisa A. 
Published: April 2016

Background: Rotator cuff tearing has been found to be clinically associated with other tendinopathies and compression neuropathies; a significant excess of these phenotypes has been seen in patients with rotator cuff tears. It is unclear if the association is secondary to environmental or genetic influences. Purpose: To examine population-based data for comorbid association of rotator cuff tearing and tendinopathies and compression neuropathies and to determine whether the association extends to relatives of patients with rotator cuff tears, which could suggest a genetic contribution. Study Design: Cross-sectional study; Level of evidence, 3. Methods: The Utah Population Database (UPDB) contains health and genealogical data on over 2 million Utah residents. Current Procedural Terminology, Fourth Revision, codes (CPT 4) and International Classification of Diseases, Ninth Revision, codes (ICD-9) entered in patient records were used to identify patients with rotator cuff tearing and with comorbid tendinopathies and compression neuropathies. We tested the hypothesis of excess familial clustering of these other phenotypes with rotator cuff tearing using a well-established method (estimation of relative risks) in the overall study group of rotator cuff patients (N = 1889). Results: Significantly elevated risk for elbow, hand/wrist, foot/ankle, knee, and hip tendinopathies, as well as for all tendinopathies and compression neuropathies, was observed in rotator cuff tear cases themselves ( P < 2.8e–13), in their spouses ( P < .02), and in their first-degree relatives ( P < 5.5e–4). A significant excess of elbow ( P = .01), foot/ankle ( P = .04), and all tendinopathies ( P = 3.1e–3) was also observed in second-degree relatives, and a significant excess of compression neuropathies ( P = .03) was observed in third-degree relatives. Conclusion: The current study shows strong evidence of familial clustering of rotator cuff tearing with other tendinopathies and with compression neuropathy. Observed increased risks in spouses and first-degree relatives supports shared environmental risk factors for rotator cuff tearing, most tendinopathies, and compression neuropathies. Increased risks to third-degree relatives for compression neuropathy suggest an association of these phenotypes that may have a shared genetic etiology.
Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions
Authors: Behrens Kira , Triviai Ioanna , Schwieger Maike , Tekin Nilgün , Alawi Malik , Spohn Michael , Indenbirken Daniela , Ziegler Marion , Müller Ursula , Alexander Warren S. , Stocking Carol 
Published: April 2016

Key PointsRunx1 is a key determinant of megakaryocyte cell-fate decisions in multipotent progenitors. Runx1 downregulates cell-adhesion factors that promote residency of stem cells and megakaryocytes in their bone marrow niche.
Loss of Ezh2 cooperates with Jak2V617F in the development of myelofibrosis in a mouse model of myeloproliferative neoplasm
Authors: Yang Yue , Akada Hajime , Nath Dipmoy , Hutchison Robert E. , Mohi Golam 
Published: April 2016

Key Points
Loss of Ezh2 inhibits erythropoiesis but increases megakaryopoiesis in Jak2V617F knock-in mice. Loss of Ezh2 induces rapid progression to myelofibrosis in mice expressing Jak2V617F.