bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Neural Networks based validation, DFT, thermal and biological evaluation of novel 4-aminoantipyrine derived Ru(III) complexes
Authors: S.S Salin Raj , Dhanaraj Chellaian Justin 
Published: September 2024

Abstract

Series of novel Schiff base ruthenium complexes were synthesized using 4-aminoantipyrine derivatives. Elemental analysis and molecular mass of synthesized complexes are in agreement with calculated values. Molar conductance measurement reveals electrolytic property. Infrared spectral data reveal the ligands as tetra dentate coordinated to metal ions via imine nitrogen atom. All the complexes show octahedral geometry, which was identified by electronic spectra and magnetic measurements. Cyclic voltammetry analysis is used to identify the redox behavior of the complexes. XRD study of ligand and complexes reveal nano crystalline. The chelates exhibit high photo catalytic efficiency in UV-spectra with methylene blue dye. Thermal decomposition is in accordance with suggested formulae of the chelates. DFT computations have been used to determine the optimized molecular structure and bond parameters. The molinspiration calculations are used to identify the adherence of metal complexes to Lipinski’s rule of Five. Antibacterial screening was carried out against the bacterium B. Substilis, S. Aureus, E. Coli and K. Pneumoniae and two fungal species viz A. Niger and C. Albicans. Anticancer activity shows that the Ru(III) complexes exhibit noticeable cytotoxic effect in the SK-MEL-28 cell line. Analytical characterization was validated using Artificial Neutral Networks (ANN). New method has been adopted for automation, to get more accurate results compared to the previous existing machine learning models, the proposed Artificial Neural Networks achieved good testing accuracy.
Assessment of long-term channel morphological changes based on remote sensing techniques, Vistula River, Poland
Authors: Sosnowska Anna 
Published: September 2024

Abstract

The research presented in this paper is an attempt to characterise morphological processes that take place in the middle Vistula River channel. The research considered different cartographical materials (maps, aerial photographs) from 1959 to 2020. The chosen fragments of the middle reach of the Vistula River were analysed for changes in the channel bar size and changes in the channel width. It was stated that changes in the river width are the reason for the emergence of channel bars. The bars that were examined are stable, and they are located at a certain distance from the river narrowing. At some of the locations, the erosion-sedimentation processes are still taking place. A methodology for river channel deformation assessment based on a comparison of aerial photographs was proposed in this research. This methodology is unique and can be successfully utilised for river channel assessment. The results provide important knowledge about the characteristics of channel processes in the middle Vistula River reach that can be used for future river management.
Emergence of the North Pacific heat storage pattern delayed by decadal wind-driven redistribution
Authors: Li Yuanlong , Duan Jing , Lyu Yilong , Jing Zhao , Wang Fan 
Published: September 2024

Abstract

Storage of anthropogenic heat in the oceans is spatially inhomogeneous, impacting regional climates and human societies. Climate models project enhanced heat storage in the mid-latitude North Pacific (MNP) and much weaker storage in the tropical Pacific. However, the observed heat storage during the past half-century shows a more complex pattern, with limited warming in the central MNP and enhanced warming in the northwest tropical Pacific. Based on observational datasets, ocean model experiments, and climate models, we show that emergence of human-induced heat storage is likely postponed in the North Pacific by natural variability to the late-21st century. Specifically, phase shifts of the Pacific Decadal Oscillation (PDO) have vitally contributed to trends in the North Pacific winds during recent decades. Changes in surface winds drove meridional heat redistribution via Rossby wave dynamics, leading to regional warming and cooling structures and a more complex historical heat storage than models project. Despite this, enhanced anthropogenic warming has already been emerging in marginal seas along the North Pacific basin rim, for which we shall prepare for the pressing consequences such as increasing marine heatwaves.
Global prevalence of human brucellosis: A systematic review and meta-analysis
Authors: Sherasiya Riyaz 
Published: September 2024

Abstract

Background and aim: Human brucellosis caused by various Brucella species is a significant global health concern, particularly in livestock-dependent regions. The disease presents with non-specific symptoms like fever, fatigue, and joint pain, often leading to complications such as endocarditis and arthritis. Accurate diagnosis of this condition is challenging due to its diverse clinical manifestations and similarities to other febrile illnesses. This study aimed to provide a comprehensive synthesis of literature on the global prevalence of human brucellosis, providing updated insights and recommendations for improving diagnostic methods and public health strategies.
Materials and Methods: In this study, a systematic search of Web of Science and Scopus was performed to extract studies from January 2000 to December 2022 using keywords “Brucellosis”, “Brucella”, “prevalence of Brucella”, “prevalence of brucellosis”, “epidemiology of Brucella”, and “epidemiology of brucellosis”. Extracted data were than imported to HubMeta, duplicates were removed, and relevant studies (original articles/abstracts in English) were screened by reviewing titles, abstracts, and full texts. Cross-sectional and retrospective studies on brucellosis prevalence were included, while case reports with fewer than ten patients, clinical trials, and studies without clear sample sizes were excluded. Data were extracted into an Excel sheet and analyzed using the Meta Essentials tool to calculate pooled, gender-specific prevalence, and continent-specific prevalence with results visualized using forest plots.
Results: Sixty-nine studies with a sample size of 2,00,1236 were included in the review. The pooled prevalence of brucellosis was 15.49% (95% CI: 12.01–18.97), with the highest prevalence observed in Palestine (76%) and the lowest in Brazil (0.64%). The prevalence by continent was 16.65% in Asia, 16.28% in Africa, and 11.09% in America. The gender-specific prevalence was 19.11% in males and 13.97% in females.
Conclusion: This meta-analysis revealed significant regional and gender disparities in the prevalence of brucellosis, with high rates in Asia and Africa and a higher prevalence in males due to occupational exposure. However, limitations such as language bias, high study heterogeneity, and uneven study distribution across countries may affect the generalizability of the results. Standardized diagnostic methods and targeted public health interventions are essential to reduce the impact of brucellosis.
Dynamics of duplicated gene regulatory networks governing cotton fiber development following polyploidy
Authors: Hu Guanjing , Xiong xianpeng , Zhu De , Grover Corrinne , Wendel Jonathan , Ma Xiongfeng 
Published: September 2024

Abstract

Cotton fiber development entails complex genome-wide gene regulatory networks (GRN) that remain mostly unexplored. Here we present integrative analyses of fiber GRNs using public RNA-seq datasets, integrated with multi-omics genomic, transcriptomic, and cistromic data. We detail the fiber coexpression dynamics and regulatory connections, validating findings with external datasets and transcription factor (TF) binding site data. We elucidate previously uncharacterized TFs that regulate genes involved in fiber-related functions and cellulose synthesis, and identify the regulatory role of two homoeologous G2-like transcription factors on fiber length. Analysis of duplicated gene expression and network relationships in allopolyploid cotton, which has two co-resident genomes (A, D), revealed novel aspects of asymmetric subgenomic developmental contributions. Whereas D-based homoeolog pairs drive higher overall gene expression from the D subgenome, TFs from the A subgenome play a preferential regulatory role in the fiber gene regulatory network. Following allopolyploid formation, it appears that the trans-regulatory roles of TFs diversified more rapidly between homoeologs than did the cis-regulatory elements of their target genes. Our approach underscores the utility of network analysis for detection of master regulators and provides fresh perspectives on fiber development and polyploid functional genomics, through the lens of co-expression and GRN dynamics.
Introducing a Validation Technique for Corridor Modeling: A Comprehensive Evaluation of Predicted Wildlife Corridors in Modern Conservation Strategies
Authors: TIWARI AMRAPALI , Saran Sameer , Avishek Kirti 
Published: September 2024

Abstract

Effective biodiversity conservation strategies are paramount in addressing the persistent challenges of habitat fragmentation. This study investigates landscape connectivity for tigers across eight protected areas in Haryana, Uttarakhand, and Uttar Pradesh within the Terai Arc Landscape. Utilizing the least cost path methodology, the research identifies the most probable pathways connecting these protected areas. Additionally, circuit theory is employed to highlight crucial conservation areas, termed pinchpoints. The primary objective is to introduce a triangulation-based validation technique for predicted corridors, calculating the accuracy of predicted corridors between the eight protected areas. The results reveal several pinchpoints that require immediate action. The highest prediction accuracy is observed for the corridor between Rajaji National Park and Sonanadi Wildlife Sanctuary/Jim Corbett National Park, whereas the lowest accuracy is noted between Jim Corbett National Park and Kishanpur Wildlife Sanctuary. This research advances the precision and credibility of corridor modeling, offering significant contributions to wildlife conservation by elucidating landscape connectivity and presenting a novel validation technique. The findings provide practical implications for policymakers, conservation practitioners, and researchers, underscoring the need for rigor and validation in developing effective strategies to preserve and sustainably manage wildlife habitats.
Anxiety, depression and other internalizing problems of young children in low and middle-income countries before the covid-19 pandemic
Authors: Martinez Adriana Maldonado , Caetano Sheila C , Davidson Leslie L , Muszkat Débora , Silva Luis M , Wilches-Gutierrez Jose L , Surkan Pamela J , Martins Silvia S 
Published: September 2024

Abstract

Introduction:This study addresses the scarcity of research on the characteristics of young children's internalizing problems in Low and Middle-Income Countries (LMICs) through a systematic review of pre-pandemic literature. It aims to provide essential insights into understanding, preventing, and intervening in internalizing problems among young children. Additionally, it lays the groundwork for future studies to explore the effects of the pandemic on mental health in young children, including potential changes in the prevalence and nature of internalizing problems.Methods:The systematic review included thirty-one studies from LMIC studies published in English, Spanish, or Portuguese before March 2020 focusing on predictors, mediators, and characterizations of internalizing symptoms in preschoolers. The studies were classified by region to identify commonalities, interests, and differences.Results:The review revealed a significant disparity in research representation across regions, with the Americas being the most extensively studied and regions like the Eastern Mediterranean and Southeast Asia lacking adequate research. Validation of behavioral problem scales in LMICs was limited, posing challenges to accurate measurement. However, findings highlighted common risk factors such as maternal characteristics and environmental influences.Conclusions:Despite limitations, this review emphasizes the urgent need for comprehensive research on internalizing problems in preschoolers, particularly in LMICs. Broadening linguistic inclusion criteria and prioritizing validation efforts for behavioral problem scales are crucial steps towards addressing research gaps. Furthermore, highlighting common risk factors and patterns across regions underscores the importance of collaborative efforts to inform effective interventions and support child mental health globally.
Efficacy of Metarhizium anisopliae against Bactrocera cucurvitae under in-vitro conditions: A meta-analysis
Authors: Salibo Andal U. 
Published: September 2024

Abstract

This study evaluated the effectiveness of the entomopathogenic fungus Metarhizium anisopliae in controlling the cucurbit fruit fly Bactrocera cucurbitae under in-vitro conditions. This research aimed to develop sustainable and eco-friendly pest management strategies to replace traditional chemical pesticides. The experiment employed a randomized complete block design with five concentrations of M. anisopliae spore solution, replicated four times with 20 fruit flies each. The media for the fungus were prepared and purified, and fruit flies were collected using pheromone traps. The treatments were applied via the spray method, and data on mortality rates, mummification times, and toxicity levels were collected. Statistical analyses, including ANOVA and log-probit analysis, were also conducted to determine the lethal concentrations and durations. The results indicate a clear dose response relationship, with higher spore concentrations leading to significantly increased mortality rates and faster mummification. A concentration of 6.0 × 105 CFU/mL was necessary for substantial population reduction, while the projected lethal concentrations for 50% and 99% mortality were approximately 2.65 × 105 CFU/mL and 1.38 × 105 CFU/mL, respectively. These findings suggest that M. anisopliae is a highly effective biocontrol agent against B. cucurbitae, and is a viable alternative to chemical pesticides. Further research is recommended to explore field applications and assess long-term ecological impacts.
Изменение клинических и лабораторных показателей в зависимости от тяжести травматического шока: ретроспективное когортное исследование
Authors: Лахин Роман Евгеньевич , Кусай А. С. , Усольцев Е. А. , Касимов Р. Р. , Цыганков К. А. , Старостин Д. О. , Шустров В. В. , Щеголев А. В. 
Published: September 2024

INTRODUCTION: Traumatic shock is a complex pathophysiological process that includes impaired tissue perfusion, the development of circulatory and tissue hypoxia, metabolic disorders, and homeostasis disorders.
MATERIALS AND METHODS: A retrospective cohort study that included 329 people with combat injury. The level of systolic blood pressure (SBP), heart rate (HR), acid-base state (CBS), general and gas blood tests were examined upon admission.
RESULTS: There were 55 patients without shock (30 %), 83 (25 %) with I degree shock, 80 (25 %) of II degree, 51 (15 %) of III degree, 16 (5 %) of IV degree. The analysis of the values of the SBP, HR and shock index (SI), base deficiency (BE) showed the presence of statistical differences depending on the degree of shock. SI without shock was 0.7 (0.7; 0.8); with shock of the I degree — 0.8 (0.7; 0.9); II degree — 1.3 (1.1; 1.5), III degree — 1.8 (1.5; 2.1), IV degree — 2.5 (2.1; 3.8). The value without shock was –3.1 (3.9; –2.2); with degree I shock –3.7 (–2.1; –6.2); II degree: –4.6 (–3.1; –6.8); III degree: –8.5 (–6.5; –11.8); IV degree: –22.1 (–15.6; –26.1). Regression analysis of the relationship with the degree of shock showed two models that described a 45.9 % and 50.2 % probability. The first model includes a constant and VE (p < 0.01). The second model includes the constant, VE and the number of platelets (p < 0.01). CONCLUSION: A retrospective analysis of clinical and laboratory parameters for traumatic shock demonstrated differences in SBP, HR, SI, red blood counts, CBS, lactate levels depending on the degree of shock. The severity of acidosis and lactate levels turned out to be higher than expected for the degree of shock, due to the nature and severity of the injuries received. Base deficiency and platelet count were associated with the severity of shock.
Cardioembolic stroke and endothelial dysfunction in men aged between 30 and 50 years
Authors: Pizov N. A. , Baranova N. S. 
Published: September 2024

Introduction. Stroke in young adults is associated with high-level socioeconomic components, and patients face the lifelong effects of the vascular catastrophe. Young patients with cardioembolic stroke make up an important subgroup of ischemic stroke patients globally. A key to optimizing treatment and preventing relapses is identifying the causes and risk factors for ischemic stroke in young adults.Aim. To assess risk factors and endothelial function status in young men with cardioembolic strokeMaterial and methods. A total of 19 patients aged 30-50 years with cardioembolic stroke underwent clinical and instrumental examinations. All patients were admitted to the Yaroslavl Vascular Center before the COVID-19 pandemic. The severity of clinical symptoms and stroke were assessed using the NIHSS scales, Modified Rankin Scale, and Rivermead Mobility Index. The main risk factors for IS including the presence of high- or moderate-risk sources of cardioembolism were reviewed. All patients underwent brain neuroimaging, ultrasound imaging, electrocardiogram, echocardioscopy, and laboratory blood testing. An ultrasound guided tourniquet test was performed to assess the brachial artery endothelial vasomotor function. Results. The average age of patients with cardioembolic stroke was 43.2 ± 6.4 years. Mechanical valve prostheses (21.1%) and isolated atrial fibrillation (42.0%) are the most common sources of cardioembolism. Other commonly identified risk factors included hypertension (73.7%), dyslipidemia (42.1%), smoking (52.6%), and prior acute myocardial infarction (42.1%). The ultrasound guided tourniquet test showed normal dilation of the brachial artery in 26.3% patients, insufficient dilatation in 42.1% patients and vasoconstriction in 31.6% patients. Statistically significant associations between the main vascular risk factors, serum markers of endothelial dysfunction and ultrasound guided tourniquet test indices were identified.Conclusion. This study demonstrated a variety of risk factors for cardioembolic stroke in young men. Lifestyle modification is responsible for the occurrence of traditional risk factors in young adults.
The first biosimilar of ultra-rapid insulin lispro: results of a double-blind randomised clamp study
Authors: Noskov S. M. , Koksharova E. O. , Arefeva A. N. , Banko V. V. , Matvienko Yu. D. , Makarenko I. E. , Drai R. V. 
Published: September 2024

Introduction. Over the years, insulin therapy has remained an important component of the complex treatment of patients with diabetes mellitus. Ultra-rapid insulin lispro is a DNA recombinant analogue of human insulin, which has a pharmacokinetic (PK) profile that is as close as possible to the endogenous insulin secretion profile, which ensures effective control of postprandial glycaemia. The development of the ultra-rapid insulin lispro biosimilar will expand the range and increase the availability of modern and safe insulin analogues for diabetic patients in Russia.Aim. To compare the PK and pharmacodynamic (PD) profiles of GP40261 (ultra-rapid insulin lispro biosimilar) and the reference Lyumjev® in healthy volunteers.Materials and methods. This was a double-blind, randomised, comparative, crossover study in healthy volunteers who were administered either the test or reference ultra-rapid insulin lispro formulation as a single dose of 0.3 IU/kg. The hyperinsulinaemic euglycaemic clamp technique was used to evaluate the pharmacokinetics and pharmacodynamics of the study products. In order to assess the biosimilarity of the products, 90% confidence intervals (CIs) were calculated for geometric mean ratios of the primary PK parameters AUCins.0-t and Cins.max. The PD parameters of the study drugs were evaluated based on the glucose infusion rate required to maintain the target glycaemic level during the clamp.Results. The 90% CIs for the geometric mean ratios of the primary PK parameters for the test and reference products were 89.41-94.55% for AUCins.0-t and 82.74-92.92% for Cins.max, which complies with the established acceptance limits of 80-125% for both parameters. The study products were also found to have comparable PD profiles of their active substances.Conclusion. This clinical study has demonstrated that GP40261 and the reference ultra-rapid insulin lispro are biosimilar and have a comparable safety profile.
A CNN-BILSTM monthly rainfall prediction model based on SCSSA optimization
Authors: Zhang Xianqi , Yang Yang , Liu Jiawen , Zhang Yuehan , Zheng Yupeng 
Published: September 2024

ABSTRACT

Meteorological conditions play an important role in China's national production, and the accurate prediction of precipitation is of great significance for social production, flood prevention, and the protection of people's lives and property. A coupled model for monthly rainfall prediction is constructed based on the convolutional neural network (CNN) and the bi-directional long- and short-term memory network (BILSTM) combined with a sparrow optimization algorithm incorporating positive cosine and Cauchy variants (SCSSA). The model combines the SCSSA optimization algorithm with the CNN-BILSTM model, capturing data features in data space as well as temporal dependencies through CNN-BILSTM to predict the relationship. Additionally, the model combines SCSSA's excellent global search capability and convergence speed to further improve the accuracy of model prediction. Based on the measured monthly rainfall data of Xi'an City from 1996 to 2020, the SCSSA-CNN-BILSTM model was compared with the SSA-CNN-BILSTM, SCSSA-BILSTM, and CNN-BILSTM models. The results show that all the evaluation indicators of the SCSSA-CNN-BILSTM model are optimal and the prediction accuracy is the highest. This shows that the proposed SCSSA-CNN-BILSTM model has high accuracy in monthly rainfall prediction and provides a new method for hydrological rainfall model predictions.