bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of the ACC/AHA lesion classification as a predictor of procedural, 30‐day and 12‐month outcomes in the contemporary percutaneous coronary intervention era
Authors: Theuerle James , Yudi Matias B , Farouque Omar , Andrianopoulos Nick , Scott Peter , Ajani Andrew E , Brennan Angela , Duffy Stephen J , Reid Christopher M , Clark David J ,   on behalf of the Melbourne Interventional Group.
Published: November 2017

AbstractBackgroundCorrelations between the ACC/AHA coronary lesion classification and clinical outcomes in the contemporary percutaneous coronary intervention (PCI) era are not well established.MethodsWe analyzed clinical characteristics and outcomes according to ACC/AHA lesion classification (A, B1, B2, C) in 13,701 consecutive patients from the Melbourne Interventional Group (MIG) registry. Patients presenting with STEMI, cardiogenic shock and out‐of‐hospital cardiac arrest were excluded. The primary endpoints were 30‐day and 12‐month mortality. Secondary endpoints were procedural success as well as 30‐day and 12‐month major adverse cardiac events.ResultsOf the 13,701 patients treated, 1,246 (9.1%) had type A lesions, 5,519 (40.3%) had type B1 lesions, 4,449 (32.5%) had Type B2 lesions and 2,487 (18.2%) had Type C lesions. Patients with type C lesions were more likely to be older and have impaired renal function, diabetes, previous myocardial infarction, peripheral vascular disease and prior bypass graft surgery (all P < 0.01). They were also more likely to require rotational atherectomy, drug‐eluting stents and longer stent lengths (all P < 0.01). Increasing lesion complexity was associated with lower procedural success (99.6% vs. 99.1% vs. 96.6% vs. 82.7%, P < 0.001) and worse 30‐day (0.2% vs. 0.3% vs. 0.7% vs. 0.6%, P < 0.001) and 12‐month mortality (2.2% vs. 2.0% vs. 3.2% vs. 2.9%, P <0.01). Kaplan Meier analysis showed complex lesions (type B2 and C) had lower survival at 12‐months (P = 0.003).ConclusionsPCI to more complex lesions continues to be associated with lower procedural success rates as well as inferior medium‐term clinical outcomes. Thus the ACC/AHA lesion classification should still be calculated preprocedure to predict acute PCI success and clinical outcomes.
A Four‐Step Synthesis of Substituted 5,11‐Dicyano‐6,12‐diaryltetracenes with Enhanced Stability and High Fluorescence Emission
Authors: Kerisit Nicolas , Gawel Przemyslaw , Levandowski Brian , Yang Yun‐Fang , García‐López Víctor , Trapp Nils , Ruhlmann Laurent , Boudon Corinne , Houk Kendall N. , Diederich François 
Published: November 2017

AbstractA four‐step synthesis of substituted 5,11‐dicyano‐6,12‐diaryltetracenes was developed, starting from readily available para‐substituted benzophenones. The key step of this straightforward route is the complex cascade reaction between tetraaryl[3]cumulenes and tetracyanoethene (TCNE) resulting in 5,5,11,11‐tetracyano‐5,11‐dihydrotetracenes. The mechanism of this transformation was reinvestigated by means of theoretical calculations. The target tetracenes were obtained by a newly developed decyanation/aromatization reaction catalyzed by CuI or CuII complexes in solution, conditions compatible with a broad range of functional groups. A computational mechanistic study sheds light on this transformation. Structures of all tetracene derivatives were confirmed by X‐ray crystallography. The presented dicyanotetracene derivatives exhibit outstanding optoelectronic properties and enhanced photostability, significantly surpassing the reference rubrene (5,6,11,12‐tetraphenyltetracene).
Assessing the Ligand Properties of NHC‐Stabilised Phosphorus(I) Cations
Authors: Binder Justin F. , Kosnik Stephanie C. , Macdonald Charles L. B. 
Published: November 2017

AbstractThe isolation and full characterisation of a series of cationic metal–carbonyl complexes bearing an N‐heterocyclic carbene stabilised phosphorus(I) ligand are reported. Specifically, the mononuclear coordination complexes [LM(CO)5][BPh4] (M=Cr, Mo, W), [LFe(CO)4][BPh4] and the dinuclear complexes [LMn2(CO)8][BPh4] and [LCo2(CO)6][BPh4], in which L=[bis(1,3,4,5‐tetramethylimidazol‐2‐ylidene)phosphanide]+, have all been isolated in the solid state and structurally confirmed by single‐crystal X‐ray diffraction. The dicationic platinum complex trans‐[L2PtCl2][BPh4]2 is also reported and fully characterised. The donor ability of [L]+ has been assessed by IR spectroscopy of its metal–carbonyl complexes and by using DFT calculations. The results suggest that [L]+ is a weak π‐acceptor with moderate donor strength and thus it bridges the gap that exists between phosphines and amines in terms of ligand properties. Collectively, these molecules represent the first crystallographically characterised cationic metal–carbonyl derivatives of a PI‐centred ligand and are a rare collection of cationic metal–carbonyl complexes.
Enantioselective Hydrogenation of Imidazo[1,2‐a]pyridines
Authors: Schlepphorst Christoph , Wiesenfeldt Mario P. , Glorius Frank 
Published: November 2017

AbstractThe enantioselective synthesis of tetrahydroimidazo[1,2‐a]pyridines by direct hydrogenation was achieved using a ruthenium/N‐heterocyclic carbene (NHC) catalyst. The reaction forgoes the need for protecting or activating groups, proceeds with complete regioselectivity, good to excellent yields, enantiomeric ratios of up to 98:2, and tolerates a broad range of functional groups. 5,6,7,8‐Tetrahydroimidazo[1,2‐a]pyridines, which are found in numerous bioactive molecules, were directly obtained by this method, and its applicability was demonstrated by the (formal) synthesis of several functional molecules.
Structure and Electronic Properties of Unnatural Base Pairs: The Role of Dispersion Interactions
Authors: Jahiruddin Sk , Mandal Nilangshu , Datta Ayan 
Published: November 2017

AbstractRecent reports of the successful incorporation of unnatural base pairs (UBPs), such as d5SICS–dNaM, in the gene sequence and replication with DNA is an important milestone in synthetic biology. Followed by this, several other UBPs, such as dTPT3–dNaM, dTPT3–dFIMO, dTPT3–IMO, dTPT3–FEMO, FTPT3–NaM, FTPT3–FIMO, FTPT3–IMO, and FTPT3–FEMO, have demonstrated similar or better retention and fidelity inside cells. Of these base pairs, dNaM–dTPT3 has been optimized to be a better fit inside a pAIO plasmid. Based on both implicit and explicit dispersion‐corrected density functional theory (DFT) calculations, we show that although this set of UBPs is significantly diverse in elemental and structural configuration, the members do share a common trait of favoring a slipped parallel stacked dimer arrangement. Unlike the natural bases (A, T, G, C, and U), this set of UBPs has a negligible affinity for a Watson–Crick (WC)‐type planar structure because they are invariably more stable within slipped parallel stacked orientations. We also observed that all the UBPs have either similar or higher binding energies with the natural bases in similar stacked orientations. When arranged between two natural base pairs, the UBPs exhibited a binding energy similar to that of three‐base sequences of natural bases. Our computational data show that the most promising base pairs are 5SICS–NaM, TPT3–NaM, and TPT3–FEMO. These results are consistent with recent progress on experimental research into UBPs along with our previous calculations on the d5SICS–dNaM pair and, therefore, strengthen the hypothesis that hydrogen bonding might not be absolutely essential and that interbase stacking dispersion interactions play a key role in the stabilization of genetic materials.
Activation of Dinitrogen with a Superalkali Species, Li3F2
Authors: Park Heejune , Meloni Giovanni 
Published: November 2017

AbstractThe capability of the superalkali Li3F2 to activate dinitrogen (N2) is presented. The (Li3F2)nN2 clusters (n=1–6) were investigated first at the MP2/6‐311+G(3d2f,2df,2p)//B3LYP/6‐311G(2d,d,p) level of theory. Clusters up to n=4 were also optimized through the CBS‐QB3 composite model. The complete dissociation of N2 was confirmed through visualized molecular orbitals and bond order calculation. The N−N bond is weakened by the addition of Li3F2 superalkali units. The enthalpy of atomization
and formation
), charge flows (Δq), binding energies, and the energy gap between the highest occupied molecular orbital and the lowest unoccupied molecular orbital are calculated to help explain the N2 activation.
Higher doses of intraoperative analgesia are associated with lower levels of persistent pain and less analgesic consumption six months after total hip arthroplasty
Authors: von Dincklage F. , Jakuscheit A. , Weth J. , Lichtner G. , Jurth C. , Rehberg‐Klug B. 
Published: November 2017

AbstractBackgroundPersistent postoperative pain is a major health problem affecting nearly 30% of all patients undergoing total hip arthroplasty. Previous studies have demonstrated an association between the intensity of acute postoperative pain and persistent pain, but this association might be an epiphenomenon of insufficient intraoperative analgesia. In this study, we investigated the association between the intraoperative level of analgesia and the persistent postoperative pain 6 months after surgery.MethodsWe investigated 110 patients undergoing primary total hip arthroplasty under total intravenous general anaesthesia in a prospective cohort study. A highly standardized surgical and a standardized anaesthetic procedure were performed to reduce variability and psychosocial influences were investigated to adjust for confounders. Acute postoperative pain was controlled using patient‐controlled analgesia pumps. Postoperative pain intensities and analgesic requirements were monitored for 6 months following surgery.ResultsOf 105 patients included in the analysis, 32% continued using daily pain medication 6 months after surgery and reported a median pain level of 4/10. Multivariate analyses confirmed that the amount of intraoperative analgesia is a significant predictor of regular analgesic use and pain intensity 6 months after surgery.ConclusionsHigher levels of intraoperative analgesia are associated with lower levels of persistent pain and less analgesic consumption 6 months after total hip arthroplasty. Persistent pain may be attributable to intraoperative nociception, which is likely not adequately assessed and suppressed using current clinical measures.SignificanceOur study suggests that lower doses of intraoperative analgesia are associated with higher levels of persistent postoperative pain. Persistent pain may be caused by intraoperative nociception, which is likely not adequately suppressed using current clinical standard analgesic measures.
Copper uptake, patterns of bioaccumulation, and effects in glochidia (larvae) of the freshwater mussel (Lampsilis cardium)
Authors: B. Jorge Marianna , Bianchini Adalto , M. Wood Chris , Gillis Patricia L. 
Published: November 2017

Abstract

The early life stages of freshwater mussels are particularly sensitive to copper (Cu) contamination. We measured the acute toxicity, bioaccumulation, and sublethal effects of Cu in glochidia. In addition, we used radiolabeled Cu (64Cu) to examine the time-dependent kinetics of uptake over 24 h. Uptake of 64Cu by live and dead glochidia exposed to 0.11 μmol/L exhibited similar hyperbolic patterns over the first 40 min, indicating an adsorptive phase independent of larval metabolism. Thereafter, uptake was linear with time, with a 10-fold lower bioaccumulation rate in live than in dead animals, representing a close to steady state of Cu regulation. In contrast, dead glochidia exhibited a progressively increasing uptake, possibly attributable to the fact that metal-binding sites become more accessible. Mortality was strongly correlated with bioaccumulation (48 h); live glochidia exposed to Cu concentrations &gt;0.27 μmol/L lost their regulatory ability and accumulated Cu to an even greater extent than dead animals. Exposure to Cu induced significant decreases in whole-body Na+ and Mg2+ concentrations; increases in reactive oxygen species concentration, lipid peroxidation, and protein carbonylation; and a decrease in antioxidant capacity against peroxyl radicals. Overall, these results clarify the patterns of Cu uptake and regulation, emphasize the importance of distinguishing between live and dead larvae, and indicate that toxicity is associated with Cu bioaccumulation, involving both ionoregulatory disturbance and oxidative stress. Environ Toxicol Chem 2018;37:1092–1103. © 2017 SETAC
Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid
Authors: Yanguas‐Casás Natalia , Crespo‐Castrillo Andrea , de Ceballos Maria L. , Chowen Julie A. , Azcoitia Iñigo , Arevalo Maria Angeles , Garcia‐Segura Luis M. 
Published: November 2017

AbstractSex differences in the incidence, clinical manifestation, disease course, and prognosis of neurological diseases, such as autism spectrum disorders or Alzheimer's disease, have been reported. Obesity has been postulated as a risk factor for cognitive decline and Alzheimer's disease and, during pregnancy, increases the risk of autism spectrum disorders in the offspring. Obesity is associated with increased serum and brain levels of free fatty acids, such as palmitic acid, which activate microglial cells triggering a potent inflammatory cascade. In this study, we have determined the effect of palmitic acid in the inflammatory profile, motility, and phagocytosis of primary male and female microglia, both in basal conditions and in the presence of a pro‐inflammatory stimulus (interferon‐γ). Male microglia in vitro showed higher migration than female microglia under basal and stimulated conditions. In contrast, female microglia had higher basal and stimulated phagocytic activity than male microglia. Palmitic acid did not affect basal migration or phagocytosis, but abolished the migration and phagocytic activity of male and female microglia in response to interferon‐γ. These findings extend previous observations of sex differences in microglia and suggest that palmitic acid impairs the protective responses of these cells.
Cognitive abilities, brain white matter hyperintensity volume, and structural network connectivity in older age
Authors: Wiseman Stewart J. , Booth Tom , Ritchie Stuart J. , Cox Simon R. , Muñoz Maniega Susana , Valdés Hernández Maria del C. , Dickie David Alexander , Royle Natalie A. , Starr John M. , Deary Ian J. , Wardlaw Joanna M. , Bastin Mark E. 
Published: November 2017

AbstractObjectiveTo assess brain structural connectivity in relation to cognitive abilities in healthy ageing, and the mediating effects of white matter hyper‐intensity (WMH) volume.MethodsMRI data were analysed in 558 members of the Lothian Birth Cohort 1936. Brains were segmented into 85 regions and combined with tractography to generate structural connectomes. WMH volume was quantified. Relationships between whole‐brain connectivity, assessed using graph theory metrics, and four major domains of cognitive ability (visuospatial reasoning, verbal memory, information processing speed and crystallized ability) were investigated, as was the mediating effects of WMH volume on these relationships.ResultsVisuospatial reasoning was associated with network strength, mean shortest path length, and global efficiency. Memory was not associated with any network connectivity metric. Information processing speed and crystallized ability were associated with all network measures. Some relationships were lost when adjusted for mean network FA. WMH volume mediated 11%–15% of the relationships between most network measures and information processing speed, even after adjusting for mean network FA.ConclusionBrain structural connectivity relates to visuospatial reasoning, information processing speed and crystallized ability, but not memory, in this relatively healthy age‐homogeneous cohort of 73 year olds. When adjusted for mean FA across the network, most relationships are lost, except with information processing speed suggesting that the underlying topological network structure is related to this cognitive domain. Moreover, the connectome‐processing speed relationship is partly mediated by WMH volume in this cohort. Hum Brain Mapp 39:622–632, 2018. © 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
Neural mechanisms of interference control in working memory capacity
Authors: Bomyea Jessica , Taylor Charles T. , Spadoni Andrea D. , Simmons Alan N. 
Published: November 2017

AbstractThe extent to which one can use cognitive resources to keep information in working memory is known to rely on (1) active maintenance of target representations and (2) downregulation of interference from irrelevant representations. Neurobiologically, the global capacity of working memory is thought to depend on the prefrontal and parietal cortices; however, the neural mechanisms involved in controlling interference specifically in working memory capacity tasks remain understudied. In this study, 22 healthy participants completed a modified complex working memory capacity task (Reading Span) with trials of varying levels of interference control demands while undergoing functional MRI. Neural activity associated with interference control demands was examined separately during encoding and recall phases of the task. Results suggested a widespread network of regions in the prefrontal, parietal, and occipital cortices, and the cingulate and cerebellum associated with encoding, and parietal and occipital regions associated with recall. Results align with prior findings emphasizing the importance of frontoparietal circuits for working memory performance, including the role of the inferior frontal gyrus, cingulate, occipital cortex, and cerebellum in regulation of interference demands.
Alleviation of cadmium‐induced oxidative stress by trehalose via inhibiting the Nrf2‐Keap1 signaling pathway in primary rat proximal tubular cells
Authors: Wang Xin‐Yu , Wang Zhen‐Yong , Zhu Yi‐Song , Zhu Si‐Ming , Fan Rui‐Feng , Wang Lin 
Published: November 2017

AbstractNuclear factor erythroid 2‐related factor 2 (Nrf2) is a transcription factor that regulates a cluster of oxidative stress‐inducible genes in cells. Here, we aimed to investigate whether trehalose (Tre) protects primary rat proximal tubular (rPT) cells against cadmium (Cd)‐induced oxidative stress via Nrf2 antioxidant pathway. Data showed that Tre treatment inhibited Nrf2 nuclear translocation and restored the decline in Kelch‐like ECH‐associated protein 1 (Keap1) protein level in Cd‐exposed rPT cells. Moreover, Cd‐activated Nrf2 target genes, including phase II detoxifying enzymes, that is, NAD(P)H quinone oxidoreductase 1 and heme oxygenase‐1, direct antioxidant proteins, that is, glutathione peroxidase, superoxide dismutase, catalase, and glutathione biosynthesis‐related proteins, that is, glutamatecysteine ligase catalytic subunit, glutamate cysteine ligase modifier subunit, and glutathione reductase, were all downregulated by co‐treatment with Tre. Collectively, these findings demonstrate that Tre treatment alleviates Cd‐induced oxidative stress in rPT cells by inhibiting the Nrf2‐Keap1 signaling pathway.
Epidemiology of therapeutic apheresis with a multidisciplinary approach at a high volume pediatric center
Authors: Sirignano Rachel M. , Paden Matthew L. , Fasano Ross , Meyer Erin K. 
Published: November 2017

IntroductionTherapeutic apheresis (TA) is used inconsistently in pediatric populations. We seek to define our multidisciplinary institutional practice.MethodsWe conducted a retrospective chart review of patients receiving TA from January 1, 2012 through October 31, 2015. Data collected included demographics, American Society of Apheresis (ASFA) indication, complications, and mortality.ResultsOver 46 months, 1198 TA procedures were conducted on 289 patients ranging in age from 5 months to 21 years with weights ranging from 4.76 to 170.3 kg (16 procedures in patients <10 kg). The procedures were 86% therapeutic plasma exchange, 10% red blood cell exchange, 4% extracorporeal photopheresis, and 5 leukocytapheresis procedures. TA was initiated in different clinical environments: 41% outpatient, 37% intensive care, 15% general inpatient, and 7% operating room. The ASFA category (6th edition) indications for the 1198 procedures included: 44% category I, 25% category II, 23% category III, a single category IV procedure, and the remainder (8%) uncategorized by ASFA. The rate of procedure failure and procedure‐related mortality are 1 and 0%, respectively. Case mortality rate was 4%.ConclusionAt a large volume pediatric hospital, TA is commonly used and can be performed safely in a variety of settings by a multidisciplinary team. This demographic review catalogs the number and type of procedures performed as a second‐line therapy or on the basis of limited evidence. Additional collaborative investigation is needed to evaluate unique implications of TA in pediatrics to maximize efficacy while preserving safety.
Understanding the association between discrimination and depression among sexual minority people of color: Evidence for diminishing returns of socioeconomic advantage
Authors: Sutter Megan , Perrin Paul B. , Trujillo Michael A. 
Published: November 2017

AbstractObjectiveTo examine the differential association of heterosexism and racism on depression as moderated by socioeconomic status (SES) among sexual minority people of color.MethodA cross‐sectional sample of sexual minority people of color (n = 170) was surveyed on their experiences of heterosexism, racism, depression, and SES in a national online study based in the United States.ResultsBivariately, SES was inversely associated with depression, racism, and heterosexism. Moderation analyses found that for individuals with less socioeconomic advantage, the associations between heterosexism and depression were not as strong. However, at higher socioeconomic advantage, heterosexism was more strongly positively associated with depression.ConclusionThese results suggest that the effects of discrimination on depression in sexual minority individuals of color may be accentuated at higher socioeconomic levels. Implications suggest helping sexual minority clients of color from higher SES backgrounds explore the effects of discrimination on their mental health.
Clique minors in double‐critical graphs
Authors: Rolek Martin , Song Zi‐Xia 
Published: November 2017

AbstractA connected t‐chromatic graph G is double‐critical if is ‐colorable for each edge . A long‐standing conjecture of Erdős and Lovász that the complete graphs are the only double‐critical t‐chromatic graphs remains open for all . Given the difficulty in settling Erdős and Lovász's conjecture and motivated by the well‐known Hadwiger's conjecture, Kawarabayashi, Pedersen, and Toft proposed a weaker conjecture that every double‐critical t‐chromatic graph contains a minor and verified their conjecture for . Albar and Gonçalves recently proved that every double‐critical 8‐chromatic graph contains a K8 minor, and their proof is computer assisted. In this article, we prove that every double‐critical t‐chromatic graph contains a minor for all . Our proof for is shorter and computer free.
99mTc‐labeled rHuEpo for imaging of the erythropoietin receptor in tumors
Authors: Zhuang Xiaoqing , Zhao Dan , Yang Pengfei , Jia Yingqin , Liang Rui , Zhao Qian , Han Chunlei , Kinsella Joseph M. , Sheng Ruilong , Li Juan 
Published: November 2017

To analyze erythropoietin receptor (EpoR) status in tumors, recombinant human erythropoietin (rHuEpo) was labeled with 99mTc by 99mTc‐centered 1‐pot synthesis, resulting in high radiochemical purity, stability, and biological activity. Both in vitro cell culture experiments and biodistribution studies of normal rats demonstrated successful EpoR targeting. The biodistribution of labeled rHuEpo in a NCI‐H1975 xenograft model showed tumor accumulation (tumor‐to‐muscle ratio, 4.27 ± 1.77), confirming the expression of active EpoR in tumors. Thus, as a novel single positron emission computerized tomography tracer for the imaging of EpoR expression in vivo, 99mTc‐rHuEpo is effective for exploring the role of EpoR in cancer growth, metastasis and angiogenesis.