bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association Between Symptomatic and Diagnostic Depression and Pain Among the Elderly Population in South Korea
Authors: Lee Wanhyung , Hong Kwanyoung , Lim Sung-Shil , Kim Dong Hyun , Yoon Jin-Ha 
Published: January 2017

Abstract
The exact nature of pain (amount or severity) associated with in depression in the elderly population has not been studied extensively yet. We investigated the association between the characteristics of pain and both symptomatic and diagnostic depression using data from the 2012 Korean Longitudinal Study of Aging (2164 men, 2066 women). Symptomatic depression was identified a score of 12 or higher on the 10-item Center for Epidemiologic Studies–Depression Scale. Odds ratios with a 95% confidence interval was calculated for depression using multiple logistic regression models after adjusting for age, sex, socioeconomic status, health behavioral factors, and chronic diseases. The fully adjusted odds ratio (95% confidence interval) for symptomatic/diagnostic depression were “1” = 2.09 (1.62–2.49)/1.71 (1.03–2.86), “2” = 1.88 (1.42–2.49)/1.82 (1.05–3.13), and “>3” = 2.27 (1.71–3.01)/3.21 (1.94–5.32), and 1.86 (1.48–2.33)/1.57 (1.00–2.49) for mild, 1.74 (1.22–2.48)/2.10 (1.11–3.98) for moderate, and 5.41 (3.77–7.77)/7.34 (4.15–12.99) for severe of pain. The results indicated a significant association between the number of sites and severity of pain and the prevalence of depression in the Korean elderly.
Anatomical Basis and Clinical Application of Synovial Flaps in the Wrist and Distal Forearm
Authors: Colen David L. , Yeh Jiun-Ting , Colen Lawrence B. 
Published: January 2017

Background:
Neuropathic symptoms after median nerve repair at the wrist or secondary to refractory carpal tunnel syndrome may become debilitating. These symptoms develop because of perineural adhesions, intraneural fibrosis, and fixation of the nerve to the transverse carpal ligament after surgery, and often require neurolysis. Interposition of vascularized soft tissue over the median nerve at the time of neurolysis prevents recurrence of such adhesions. The synovial flap, fashioned from the synovial lining of the flexor tendon sheath, is an ideal tissue for this purpose. Previous authors have described the surgical technique of the synovial flap, but the anatomical basis and design of the flap have not been previously discussed.

Methods:
Twenty fresh cadaver upper extremities were injected with Microfil to analyze the arterial anatomy, flap dimensions, and arc of rotation of the flexor tendon synovium mobilized as a flap suitable for coverage of the median nerve at the wrist. The authors determined that both radial and ulnar-based flaps are clinically useful for providing coverage in the wrist and distal forearm. This flap was used in 18 patients with complicated median nerve lesions in this region.

Results:
All patients had an uncomplicated postoperative course. Of 13 patients treated for posttraumatic median nerve neuromas, all but two had significant resolution of symptoms.

Conclusions:
When used as a vascularized flap, the flexor tendon synovium provides adequate protection of the median nerve. Flap dimensions and vascularity of this tissue make it an ideal local flap option when performing reoperative surgery on the median nerve.
Leveraging biological insight and environmental variation to improve phenotypic prediction: Integrating crop growth models (CGM) with whole genome prediction (WGP)
Authors: Messina C.D , Technow F. , Tang T. , Totir R. , Gho C. , Cooper M. 
Published: January 2017

AbstractA successful strategy for prediction of crop yield that accounts for the effects of genotype and environment will open up many opportunities for enhancing the productivity of agricultural systems. Crop growth models (CGMs) have a history of application for crop management decision support. Recently whole genome prediction (WGP) methodologies have been developed and applied in breeding to enable prediction of crop traits for new genotypes and thus increase the size of plant breeding programs without the need to expand expensive field testing. The presence of Genotype-by-Environment-by-Management (G×E×M) interactions for yield presents a significant challenge for the development of prediction technologies for both product development by breeding and product placement within agricultural production systems. The integration of a CGM into the algorithm for whole genome prediction WGP, referred to as CGM-WGP, has opened up the potential for prediction of G×E×M interactions for breeding and product placement applications. Here a combination of simulation and empirical studies are used to explain how the CGM-WGP methodology works and to demonstrate successful reduction to practice for applications to maize breeding and product placement recommendation in the US corn belt.
Mechanical interactions in bacterial colonies and the surfing probability of beneficial mutations
Authors: Farrell Fred F. , Gralka Matti , Hallatschek Oskar , Waclaw Bartlomiej 
Published: January 2017

AbstractBacterial conglomerates such as biofilms and microcolonies are ubiquitous in nature and play an important role in industry and medicine. In contrast to well-mixed, diluted cultures routinely used in microbial research, bacteria in a microcolonv interact mechanically with one another and with the substrate to which they are attached. Despite their ubiquity, little is known about the role of such mechanical interactions on growth and biological evolution of microbial populations. Here we use a computer model of a microbial colony of rod-shaped cells to investigate how physical interactions between cells determine their motion in the colony, this affects biological evolution. We show that the probability that a faster-growing mutant “surfs” at the colony’s frontier and creates a macroscopic sector depends on physical properties of cells (shape, elasticity, friction). Although all these factors contribute to the surfing probability in seemingly different ways, they all ultimately exhibit their effects by altering the roughness of the expanding frontier of the colony and the orientation of cells. Our predictions are confirmed by experiments in which we measure the surfing probability for colonies of different front roughness. Our results show that physical interactions between bacterial cells play an important role in biological evolution of new traits, and suggest that these interaction may be relevant to processes such asde novoevolution of antibiotic resistance.
The neutral frequency spectrum of linked sites
Authors: Ferretti Luca , Klassmann Alexander , Raineri Emanuele , Ramos-Onsins Sebastián E. , Wiehe Thomas , Achaz Guillaume 
Published: January 2017

AbstractWe introduce the conditional Site Frequency Spectrum (SFS) for a genomic region linked to a focal mutation of known frequency. An exact expression for its expected value is provided for the neutral model without recombination. Its relation with the expected SFS for two sites, 2-SFS, is discussed. These spectra derive from the coalescent approach of Fu (1995) for finite samples, which is reviewed. Remarkably simple expressions are obtained for the linked SFS of a large population, which are also solutions of the multiallelic Kolmogorov equations. These formulae are the immediate extensions of the well known single siteθ/fneutral SFS. Besides the general interest in these spectra, they relate to relevant biological cases, such as structural variants and introgressions. As an application, a recipe to adapt Tajima’sDand other SFS-based neutrality tests to a non-recombining region containing a neutral marker is presented.
It’s okay to be green: Draft genome of the North American bullfrog (Rana [Lithobates] catesbeiana)
Authors: Hammond S. Austin , Warren René L. , Vandervalk Benjamin P. , Kucuk Erdi , Khan Hamza , Gibb Ewann A. , Pandoh Pawan , Kirk Heather , Zaho Yongjun , Jones Martin , Mungall Andrew J. , Coope Robin , Pleasance Stephen , Moore Richard A. , Holt Robert A. , Round Jessica M. , Ohora Sara , Walle Branden V. , Veldhoen Nik , Helbing Caren C. , Birol Inanc 
Published: January 2017

AbstractFrogs play important ecological roles as sentinels, insect control and food sources. Several species are important model organisms for scientific research to study embryogenesis, development, immune function, and endocrine signaling. The globally-distributed Ranidae (true frogs) are the largest frog family, and have substantial evolutionary distance from the model laboratoryXenopusfrog species. Consequently, the extensiveXenopusgenomic resources are of limited utility for Ranids and related frog species. More widely applicable amphibian genomic data is urgently needed as more than two-thirds of known species are currently threatened or are undergoing population declines.Herein, we report on the first genome sequence of a Ranid species, an adult male North American bullfrog (Rana [Lithobates] catesbeiana). We assembled high-depth Illumina reads (66-fold coverage), into a 5.8 Gbp (NG50 = 57.7 kbp) draft genome using ABySS v1.9.0. The assembly was scaffolded with LINKS and RAILS using pseudo-long-reads from targeteddenovoassembler Kollector and Illumina Synthetic Long-Reads, as well as reads from long fragment (MPET) libraries. We predicted over 22,000 protein-coding genes using the MAKER2 pipeline and identified the genomic loci of 6,227 candidate long noncoding RNAs (IncRNAs) from a composite reference bullfrog transcriptome. Mitochondrial sequence analysis supportedLithobatesas a subgenus ofRana.RNA-Seq experiments identified ~6,000 thyroid hormone– responsive transcripts in the back skin of premetamorphic tadpoles; the majority of which regulate DNA/RNA processing. Moreover, 1/6thof differentially-expressed transcripts were putative lncRNAs. Our draft bullfrog genome will serve as a useful resource for the amphibian research community.
Effects of time and isolation on plant diversity: testing island biogeography theory with an eco-evolutionary model
Authors: Sarmento Cabral Juliano , Whittaker Robert J. , Wiegand Kerstin , Kreft Holger 
Published: January 2017

abstractAimsThe General Dynamic Model of oceanic island biogeography (GDM) predicts how biogeographical rates, species richness, and endemism vary depending on island age, area, and isolation, based on the interplay of colonization, extinction, and speciation. Here, we used a simulation model to test whether GDM predictions may arise from individual- and population-level processes.LocationHypothetical hotspot islands.MethodsOur model (i) considers an idealized island ontogeny, (ii) metabolic constraints, and (iii) stochastic, spatially-explicit, and niche-based processes at the level of individuals and populations (plant demography, dispersal, competition, mutation, and speciation). Isolation scenarios involved varying dispersal ability and distances to mainland.ResultsHumped temporal trends were obtained for species richness, endemic richness, proportion of cladogenetic endemic species, number of radiating lineages, number of species per radiating lineage, and biogeographical rates. The proportion of anagenetic endemics and of all endemics steadily increased over time. Extinction rates of endemic species peaked later than for non-endemic species. Species richness and the number of anagenetic endemics decreased with isolation as did rates of colonization, anagenesis, and extinction. The proportion of all endemics and of cladogenetic endemics, the number of cladogenetic endemics, of radiating lineages, and of species per radiating lineage, and the cladogenesis rate all increased with isolation.Main conclusionsThe results confirm most GDM predictions related to island ontogeny and isolation, but predict an increasing proportion of endemics throughout the experiment: a difference attributable to diverging assumptions on late island ontogeny. New insights regarding the extinction trends of endemics further demonstrate how simulation models focusing on low ecological levels provide tools to test biogeographical-scale predictions and to develop more detailed predictions for further empirical tests.
Telomere elongation and Telomerase activity in Normal and Cancer cell lines: HEK-293, HeLa and A549
Authors: Patel Ankur , Joshi Grishma , Fu Yunke , Shaju Sherwin , Messina Angelo 
Published: January 2017

AbstractTelomerase, an eukaryotic ribonucleoprotein (RNP) complex, consists of an essential RNA template and a reverse transcriptase termed as human telomerase reverse transcriptase (hTERT). By using this reverse transcriptase enzyme, telomerase RNP maintains its telomeric length in all cancer cells and in few stem cells. As cells age, telomerase level decreases and telomere get shorten, leading to senescence. Presence of telomerase helps delay the senescence due to active production of telomere, leading to cell turning malignant and eventually cancerous. In this experiment, we would investigate the telomerase activity tested using q PCR and telomerase level using western blot in three different cell lines, HEK-293, HeLa and A549.HypothesisWhere HEK-293 cells have longer telomeres and higher telomerase activity, HeLa and A549 cell lines will have varied length of telomere but higher telomerase activity.
A systematic comparison of error correction enzymes by next-generation sequencing
Authors: Lubock Nathan B. , Zhang Di , Church George M. , Kosuri Sriram 
Published: January 2017

AbstractGene synthesis, the process of assembling gene-length fragments from shorter groups of oligonucleotides (oligos), is becoming an increasingly important tool in molecular and synthetic biology. The length, quality, and cost of gene synthesis is limited by errors produced during oligo synthesis and subsequent assembly. Enzymatic error correction methods are cost-effective means to ameliorate errors in gene synthesis. Previous analyses of these methods relied on cloning and Sanger sequencing to evaluate their efficiencies, limiting quantitative assessment and throughput. Here we develop a method to quantify errors in synthetic DNA by next-generation sequencing. We analyzed errors in a model gene assembly and systematically compared six different error correction enzymes across 11 conditions. We find that ErrASE and T7 Endonuclease I are the most effective at decreasing average error rates (up to 5.8-fold relative to the input), whereas MutS is the best for increasing the number of perfect assemblies (up to 25.2-fold). We are able to quantify differential specificities such as ErrASE preferentially corrects C/G → G/C transversions whereas T7 Endonuclease I preferentially corrects A/T → T/A transversions. More generally, this experimental and computational pipeline is a fast, scalable, and extensible way to analyze errors in gene assemblies, to profile error correction methods, and to benchmark DNA synthesis methods.
Environmental liabilities and diversity in practice under international financial reporting standards
Authors: Schneider Thomas , Michelon Giovanna , Maier Michael 
Published: January 2017

Purpose
The purpose of this paper is to encourage accounting regulators to address diversity in practice in the reporting of environmental liabilities. When Canada changed to International Financial Reporting Standards (IFRS) in 2011, Canadian regulators asked the IFRS Interpretations Committee to interpret whether the discount rate to value environmental liabilities should be a risk-free discount rate. Old Canadian GAAP, and current US GAAP, allow for a higher discount rate, resulting in commensurately lower liabilities. International regulators refused to address this issue expecting no diversity in practice in Canada.

Design/methodology/approach
The focus is on a sample of Canadian oil and gas and mining firms. These domestic industries play a major role internationally and have significant environmental liabilities. The method is empirical archival, tracking firm characteristics and discount rate choice on transition to IFRS.

Findings
There is significant diversity in practice. About one-third of the sample firms choose a higher discount rate, avoiding a major increase in environmental liabilities on transition to IFRS. The evidence suggests that these firms have relatively larger environmental liabilities and that the discount rate decision is a strategic choice.

Research limitations/implications
The sample is based on one country and may only be reflecting local anomalies that have no broader implications.

Practical implications
Diversity in practice in accounting for environmental liabilities is not acceptable. Accounting regulators should act to create consistent and comparable reporting practice.

Social implications
Firms and managers facing larger environmental liabilities can choose to minimize environmental liabilities under IFRS, while it is the general public and society at large that bear the ultimate risk.

Originality/value
The paper pushes forward the debate on whether recognized environmental liabilities should reflect the interests of equity investors, or if other investors and stakeholders should be taken into account.
Rhetorical impression management in the letter to shareholders and institutional setting
Authors: Aerts Walter , Yan Beibei 
Published: January 2017

PurposeUsing composite style measures of the letter to shareholders, the purpose of this paper is to elaborate dominant rhetorical profiles and qualify them from an impression management (IM) perspective. In addition, the paper examines how institutional differences affect rhetorical profiles by comparing intensity and contingencies of rhetorical profiles of UK and US companies.Design/methodology/approachThe authors use automated text analysis to capture linguistic style characteristics of a panel of UK and US companies and employ factor analysis to determine rhetorical profiles. Next, the authors investigate company-level and country-level determinants of a company’s rhetorical stance.FindingsThe authors document three prominent rhetorical profiles: an emphatic acclaiming stance, a cautious plausibility-based framing position, and a logic-based rationalizing orientation. The profiles represent distinct self-presentational logics and have different readability effects. Rhetorical IM is stronger in US companies, but higher expected scrutiny in the US institutional environment affects sensitivity of rhetorical postures to message credibility and litigation risk, while marginally increasing the less litigation-sensitive defensive framing style in US letters.Originality/valueThe authors develop replicable archival-based measures of prominent rhetorical IM traits of the shareholder letter, based on composite style features. The authors argue that they are qualitatively different from content-based IM proxies. The authors investigate their institutional and organizational relevance by examining how company features and country-level differences affect incentives and constraints for style-based rhetorical IM.
The adoption and success of contemporary management accounting practices in the public sector
Authors: Nuhu Nuraddeen Abubakar , Baird Kevin , Bala Appuhamilage Appuhami 
Published: January 2017

Purpose
The purpose of this paper is to examine the association between the interactive and diagnostic use of MCSs with the extent of adoption of contemporary management accounting practices, and the subsequent impact on the success of such practices in the public sector.

Design/methodology/approach
Data were collected through the distribution of a mail survey of 740 questionnaires to public sector organisations in Australia, and analysed using structural equation modelling.

Findings
The study found that both the interactive and diagnostic approaches to using MCSs exhibit a positive association with the adoption of contemporary management accounting practices, both as a package and individually. In addition, while the level of success of contemporary management accounting practices was moderate, it was found that the extent of adoption of the practices enhanced their success.

Practical implications
The findings suggest that by intensifying the use of MCSs in a more interactive and diagnostic manner, public sector organisations are more likely to adopt contemporary management to a greater extent, with the subsequent increase in the extent of adoption of such practices to exacerbate their success.

Originality/value
The study contributes to the MCS contingency-based research by highlighting the interrelationship between two aspects of MCSs, the use of controls and the adoption and success of management accounting practices.
Gastronomic festivals: attitude, motivation and satisfaction of the tourist
Authors: López-Guzmán Tomás , Uribe Lotero Claudia Patricia , Pérez Gálvez Jesús Claudio , Ríos Rivera Ingrid 
Published: January 2017

Purpose
The purpose of this paper is the segmentation of the tourists who visit a gastronomic festival in the city of Guayaquil, Ecuador, in accordance with their perceptions with respect to gastronomy.

Design/methodology/approach
To achieve this objective, the methodology used in this research has been the application of a multivariate technique of grouping items and the realisation of a post hoc single variate ANOVA analysis.

Findings
The principal conclusions resulting from this research are focussed on the segmentation of the tourists in three different groups and how the travellers’ interest in gastronomy leads to greater satisfaction with the destination.

Practical implications
The main practical implications are centred on better understanding of the key factors of how gastronomy can reinforce a tourist destination and produce greater satisfaction for the traveller.

Originality/value
Gastronomy is used as a source of inspiration in tourist destinations. This research reinforces this theme, taking on the study of a gastronomic festival in an important business destination, such as the city of Guayaquil, in a geographic area, Latin America, characterised by a recognised gastronomy but still little studied in the scientific literature.
Evaluation of performance index in resilient supply chain: a fuzzy-based approach
Authors: Sahu Anoop Kumar , Datta Saurav , Mahapatra S.S. 
Published: January 2017

Purpose
The purpose of this paper is to develop a multi-level hierarchical framework (evaluation index system) toward evaluating an “appraisement index” from the prospectus of measuring and monitoring resilient performance of the candidate industry.

Design/methodology/approach
In this reporting, vagueness, imprecision, as well as inconsistency associated with subjective evaluation information (aligned with ill-defined assessment indices of SC resilience performance), has been tackled by the application of fuzzy theory.

Findings
Subjective evaluation information (expressed in linguistic term) acquired from the committee of decision makers (called expert group), against different resilience indices/metrics, has been fruitfully explored through the proposed fuzzy-based resilience performance appraisement module. Finally, a case study from an Indian automobile company has been conducted from the perspective of checking effectiveness of the proposed methodology for evaluation of appraisement index indicating SC resilience extent.

Originality/value
This methodology might be successfully applied to help other decision-making problems from the perspective of performance appraisal and benchmarking of candidate alternatives/choices under predefined criteria and subjective evaluation circumstances.