bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating Clinical Benefits of a Novel Sleep-Focused Mind-Body Program on Gulf War Illness Symptoms: A Randomized Controlled Trial
Authors: Nakamura Yoshio , Lipschitz David L. , Donaldson Gary W. , Kida Yuri , Williams Samuel L. , Landward Richard , Glover Don W. , West Gavin , Tuteja Ashok K. 
Published: April 2017

ABSTRACT

Objective
Mind-Body Bridging (MBB) has been shown to be effective for improving disturbed sleep. In this prospective randomized controlled trial, we evaluated the efficacy of sleep-focused MBB compared with sleep education control (SED) for improving sleep in previously deployed Gulf War veterans.

Methods
US military service members with sleep and physical health complaints who were deployed in 1990–1991 were randomized to receive three weekly sessions of either MBB (n = 33) or SED (n = 27) between 2012 and 2015. The primary outcome of Medical Outcomes Study Sleep Scale was completed at baseline, weekly during treatment, postintervention, and 3-month follow-up. Secondary outcome measures for posttraumatic stress disorder, depression, fatigue, quality of life, symptom severity, and mindfulness were completed at baseline, postintervention and 3-month follow-up. Salivary samples were collected at five time points per day at each visit for cortisol and α-amylase assessment. Clinician-administered assessments of sleep and co-occurring conditions were conducted at baseline and postintervention.

Results
MBB was significantly more efficacious than SED in reducing disturbed sleep at follow-up (F(1,180.54) = 4.04, p = .046). In addition, self-reported posttraumatic stress disorder (F(1,56.42) = 4.50, p = .038) for the treatment effect, depression (F(1,93.70) = 4.44, p = .038), and fatigue symptoms (F(1,68.58) = 3.90, p = .050) at follow-up improved in MBB compared with those in SED. Consistently higher percentages of veterans in MBB reported improvements of sleep, pain, and composite sleep/general co-occurring symptoms at the postclinical evaluation, as compared with veterans in SED. Finally, the mean waking level of salivary α-amylase in the MBB declined to a greater extent than that in the SED, at follow-up (F(1,88.99) = 3.78, p = .055), whereas no effects were found on cortisol.

Conclusions
Sleep-focused MBB can improve sleep and possibly also co-occurring symptoms in Gulf War veterans.

Clinical Trial Registration
Clinicaltrials.gov, NCT01543997.
Causal analyses, statistical efficiency and phenotypic precision through Recall-by-Genotype study design
Authors: Corbin Laura J. , Tan Vanessa Y. , Hughes David A. , Wade Kaitlin H. , Paul Dirk S. , Tansey Katherine E. , Butcher Frances , Dudbridge Frank , Howson Joanna M. , Jallow Momodou W. , John Catherine , Kingston Nathalie , Lindgren Cecilia M. , O’Donavan Michael , O’Rahilly Steve , Owen Michael J. , Palmer Colin N.A. , Pearson Ewan R. , Scott Robert A. , Heel David A. van , Whittaker John , Frayling Tim , Tobin Martin D. , Wain Louise V. , Evans David M. , Karpe Fredrik , McCarthy Mark I. , Danesh John , Franks Paul W. , Timpson Nicholas J. 
Published: April 2017

AbstractGenome-wide association studies have been useful in identifying common genetic variants related to a variety of complex traits and diseases; however, they are often limited in their ability to inform about underlying biology. Whilst bioinformatics analyses, studies of cells, animal models and applied genetic epidemiology have provided some understanding of genetic associations or causal pathways, there is a need for new genetic studies that elucidate causal relationships and mechanisms in a cost-effective, precise and statistically efficient fashion. We discuss the motivation for and the characteristics of the Recall-by-Genotype (RbG) study design, an approach that enables genotype-directed deep-phenotyping and improvement in drawing causal inferences. Specifically, we present RbG designs using single and multiple variants and discuss the inferential properties, analytical approaches and applications of both. We consider the efficiency of the RbG approach, the likely value of RbG studies for the causal investigation of disease aetiology and the practicalities of incorporating genotypic data into population studies in the context of the RbG study design. Finally, we provide a catalogue of the UK-based resources for such studies, an online tool to aid the design of new RbG studies and discuss future developments of this approach.
Can Zika account for the missing babies?
Authors: Coelho Flávio Codeço , Armstrong Margaret , Saraceni Valeria , Lemos Cristina 
Published: April 2017

AbstractThe Zika virus (ZIKV) spread rapidly in Brazil in 2015 and 2016. Rio de Janeiro was among the Brazilian cities which were hit the hardest, with more that a hundred thousand confirmed cases up to the end of 2016. Given the severity of the neurological damage caused by ZIKV on fetuses, we wondered whether it would also cause an increase in the number of miscarriages, especially very early ones. As early miscarriages are unlikely to be recorded as a health event, this effect – if it occurred – would only show up as a reduction in the number of live births. In this paper we show that there was a 15% drop in live births between September and December 2016 compared to the previous year, and that this sharp drop from epidemiological week 33 onward is strongly correlated with the number of recorded cases of Zika about 40 weeks earlier. We postulate that ZIKV is directly responsible for this drop in the birth rate. Further work is required to ascertain whether other factors such the fear of having a microcephaly baby or the economic crisis are having a significant effect.
An organ-on-a-chip approach for investigating root-environment interactions in heterogeneous conditions
Authors: Stanley Claire E. , Shrivastava Jagriti , Brugman Rik , van Swaay Dirk , Grossmann Guido 
Published: April 2017

AbstractPlants adapt their root morphology in response to changing environmental conditions, yet it remains largely unknown to what extent developmental adaptations are based on systemic or cell-autonomous responses. We present the dual-flow-RootChip (dfRootChip), a microfluidic organ-on-a-chip platform for asymmetric perfusion of Arabidopsis roots to investigate root-environment interactions under simulated environmental heterogeneity. Applications range from root guidance, monitoring of physiology and development under asymmetric conditions, tracing molecular uptake and selective drug treatments to local inoculation with microbes. We measured calcium responses in roots treated with biotic and abiotic elicitors and observed elicitor-specific signal propagation across the root from treated to untreated cells. We provide evidence for non-autonomous positive regulation of hair growth across the root upon exposure to unfavourable conditions on the opposite side. Our approach sheds light on lateral coordination of morphological adaptation and facilitates studies on root physiology, signalling and development in heterogeneous environments at the organ level.
Contextual Autocomplete: A Novel User Interface Using Machine Learning to Improve Ontology Usage and Structured Data Capture for Presenting Problems in the Emergency Department
Authors: Greenbaum Nathaniel R. , Jernite Yacine , Halpern Yoni , Calder Shelley , Nathanson Larry A. , Sontag David , Horng Steven 
Published: April 2017

AbstractObjectiveTo determine the effect of contextual autocomplete, a user interface that uses machine learning, on the efficiency and quality of documentation of presenting problems (chief complaints) in the emergency department (ED).Materials and MethodsWe used contextual autocomplete, a user interface that ranks concepts by their predicted probability, to help nurses enter data about a patient’s reason for visiting the ED. Predicted probabilities were calculated using a previously derived model based on triage vital signs and a brief free text note. We evaluated the percentage and quality of structured data captured using a prospective before-and-after study design.ResultsA total of 279,231 patient encounters were analyzed. Structured data capture improved from 26.2% to 97.2% (p<0.0001). During the post-implementation period, presenting problems were more complete (3.35 vs 3.66; p=0.0004), as precise (3.59 vs. 3.74; p=0.1), and higher in overall quality (3.38 vs. 3.72; p=0.0002). Our system reduced the mean number of keystrokes required to document a presenting problem from 11.6 to 0.6 (p<0.0001), a 95% improvement.DiscussionWe have demonstrated a technique that captures structured data on nearly all patients. We estimate that our system reduces the number of man-hours required annually to type presenting problems at our institution from 92.5 hours to 4.8 hours.ConclusionImplementation of a contextual autocomplete system resulted in improved structured data capture, ontology usage compliance, and data quality.
Transaction formalism protocol tool in infrastructure management
Authors: Zeb Jehan , Froese Thomas 
Published: April 2017

Purpose
The purpose of this paper is to develop an eight-step procedure – transaction formalism protocol (TFP) – in the area of infrastructure management. The proposed TFP is developed from two perspectives: TFP Specification (conceptual) and TFP Tool (application). This paper introduces the TFP Specification and discusses the TFP Tool in detail.

Design/methodology/approach
To develop the proposed TFP Tool, a five-step methodology was used: identify and select existing standards, benchmark standards, link and build on these standards, develop the proposed TFP Tool and validate the protocol.

Findings
The TFP Specification defines each step as a function for which inputs, controls, mechanisms, tools/techniques and outputs are specified. The TFP Tool comprises a set of forms and guidance that the transaction development personnel, including transaction analysts, transaction designers, software developers, process modellers and industry experts, will use to define transactions in infrastructure management domain.

Practical implications
The proposed TFP Tool enables transaction development personnel to define transactions effectively and efficiently for information and communication technology (ICT)-based solutions through defining information in a structured, consistent and easy way.

Originality/value
The TFP Tool was built on existing standards incorporating their shortcomings, including lack of a step-by-step procedure to help guide the personnel what to do next, lack of transaction monitoring and improvement steps and lack of standardised forms to collect information in a prescribed format for implementation in ICT-based collaboration systems. The proposed Tool was evaluated and found to be feasible, usable and useful.
Stock market reactions to layoff announcements – analysis of the renewable energy sector
Authors: Kunert Stephan , Schiereck Dirk , Welkoborsky Christopher 
Published: April 2017

PurposeThis study aims to analyze stock market reactions to layoff announcements in the renewable energy sector. The global renewable energy sector and most of the producers of wind and solar energy equipment are struggling. While changes in the regulation and in the promotion of energy production from renewable sources reduced the attractiveness of these technologies, many involved companies had to downsized their workforce to increase performance. The public often perceives these announcements as a way of increasing shareholder wealth at the cost of the employees. Support for this claim is often given in the form of isolated case study considerations. However, the case may be different for the renewable energy sector as changes in the overall institutional environment have sustainably deteriorated the prospects of this industry.Design/methodology/approachThis study analyses stock market reactions of 65 layoff announcements made by companies in the renewable energy industry in the years from 2005 to 2014. The reactions are measured by cumulative abnormal returns, which are obtained by using the event study methodology.FindingsIt shows a significantly negative market reaction to the announcement of a layoff plan on the event day. The findings are generally in line with our expectations and underline the negative perspectives of the sector from a capital market point of view and the declining importance of the sector with respect to employment numbers.Originality/valueThe results of this study are important for investors when estimating the capital market reactions to layoff announcements and when they form their own expectations regarding possible future layoff announcements. For the public, the results are of interest as the prejudice, that layoff plans are used to increase shareholder wealth, can be dismantled. The opposite is shown.
Stakeholder dialogue on Facebook
Authors: Martin Sebastian 
Published: April 2017

Purpose
German, Austrian and Swiss utilities are confronted with radical changes in the European energy sector. A dialogue between the utility companies and their various groups of stakeholders is gaining importance. Increasingly, utilities create their own Facebook presence enabling such a dialogue. Still, to the best of the author’s knowledge there exists no research which explicitly focuses the stakeholder dialogue of German, Austrian or Swiss utilities on Facebook. Therefore, the purpose of this paper is to
analyse Facebook as an instrument for dialogic communication in the energy sector.

Design/methodology/approach
An online survey was distributed to 1,280 German, Austrian and Swiss utilities, and 14 per cent of the utilities completed the survey, including 130 German, 19 Austrian and 25 Swiss companies. The participating utilities are primarily in public ownership.

Findings
The Facebook conversation of utility companies and their stakeholders meets the basic requirements of a virtual stakeholder dialogue. Nevertheless, less than half of the companies perceive their current stakeholder conversation on Facebook as truly interactive. Therefore, even if the basic requirements of a dialogue are met, most companies still do not seem to fully use the dialogue potential of Facebook.

Originality/value
This study provides first insights into virtual stakeholder dialogues in the energy sector. A suggestion to operationalise such a virtual dialogue is provided. Both operationalisation as well as the empirical results help researchers and practitioners to better understand virtual stakeholder dialogues.
The combined effect of product returns experience and switching costs on B2B customer re-purchase intent
Authors: Russo Ivan , Confente Ilenia , Gligor David M. , Cobelli Nicola 
Published: April 2017

PurposeThis study investigated business-to-business (B2B) repeated purchase intent and its relationships with customer value and customer satisfaction. Additionally, it explored the link between willingness to purchase again, switching costs and product returns management. Modern customers are more likely to switch suppliers; however, previous research suggests that this behaviour can be attenuated by a robust returns management experience. The purpose of this study was to provide a revised model of B2B repeated purchase intent that integrates the concept of product returns management and switching costs with existing B2B customer repurchase intent models.Design/methodology/approachFirst, a qualitative inquiry based on semi-structured interviews was conducted to test and develop a quantitative survey. Then a survey was then sent to business owners operating in the audiology industry. Finally, there were 317 responses.FindingsThe authors reveal the complex relationship between returns management and repeated purchase intent. Specifically, the authors’ results indicate that the effect of product returns on repurchase intent is opposite to the effect of customer value, depending on the value of customer value. The authors’ findings indicate that even when switching costs are low, firms can positively impact the intent to purchase again in the future if they increase the level of customer satisfaction. In addition, the authors’ findings indicate that in the context of B2B a high/low level of customer satisfaction does not trigger a positive effect of managing product returns on repurchase intent.Originality/valueThis study was the first to introduce the concept of product returns management to research on B2B repurchase intent.
Macroeconomic impact on trade show goals
Authors: Adams Russell , Coyle Tom , Downey Clara , Lovett Marvin 
Published: April 2017

Purpose
This paper aims to determine what impact an economic recession and recovery had on the selling and non-selling activities of trade show attendees and the subsequent marketing tactic changes.

Design/methodology/approach
Samples were collected from an international trade show during the recession (2009) and during the recovery (2013). The responses were analyzed using ANOVA and structural equation modeling to establish significant changes in activities between the periods and to provide a factor model.

Findings
Direct selling goals do not change during economic conditions. Intangible priorities increase during recessions.

Research limitations/implications
The trade show is limited to one location; therefore, is not a representative sample. Questionnaire design issues did not allow the linking of survey respondents to specific companies; therefore, is not a true longitudinal study.

Practical implications
Companies should focus on prospecting, enhancing corporate image and morale, testing and introducing new products and gathering intelligence during economic downturns. Conversely, companies should focus on sales and servicing clients during economic recovery.

Originality/value
This is the first research to study the macroeconomic impact on marketing tactics over multiple periods in an international setting. Several accepted selling and non-selling instrument goals are measured in an international context. A new model for structuring trade show goals is developed.
Crossing the border: changes in self and brands
Authors: Guzmán Francisco , Paswan Audhesh K. , Fabrize Robert O. 
Published: April 2017

Purpose
Migration shapes our societies, values, markets, consumption and even the notion of self. The purpose of this paper is to investigate the effect of migration in the perception-of-self and if differences in the perception-of-self influence the perception of brands from the immigrants’ home country – which immigrants often use as a cultural anchor.

Design/methodology/approach
Using Aaker’s (1997) brand personality scale as a measure of brand image, the authors gather data from Mexico City and the Dallas/Fort Worth metropolitan area. Respondents to an interviewer-administered questionnaire were asked to evaluate the brand image of two TV media Mexican brands and their perception-of-self based on Aaker’s 42 brand personality traits.

Findings
The results of this paper indicate that the perception-of-self is different for Latinos residing in their home country and immigrant Latinos living abroad. Further, these differences in the perception-of-self appear to influence the way immigrants perceive brands from their home country.

Practical implications
Brands from emerging markets making inroads into developed markets, targeting their country’s diasporas as their first target group, should understand whether people’s perception-of-self differs significantly from their home country counterparts, the direction of such a difference and the effect of such differences on the perceptions of brands from their home country.

Originality/value
This paper is a contribution to the brand personality, brand image and self literature and presents an innovative approach to analyzing the possible brand image implications of the expansion of multinational companies and immigration.
Distinguishing homicide, violent sexual, and violent juvenile offending
Authors: Baglivio Michael T. , Wolff Kevin T. 
Published: April 2017

Purpose
The purpose of this paper is to examine temperament differences, notably effortful control and negative emotionality, and correlates that distinguish between homicide, violent sexual and other violent juvenile offenders. Exploring heterogeneity among violent offenders is relevant to intervention strategies and policy implications.

Design/methodology/approach
Demographic measures, temperament constructs and individual risk factor indicators were assessed across 30,303 violent juvenile offenders (including 397 homicide offenders) in Florida to assess their ability to distinguish among violent juvenile offender subgroups.

Findings
Analyses demonstrated temperament constructs distinguish among classifications of violent juvenile offenders with effortful control differentiating homicide and violent sexual offenders from other violent offenders, and negative emotionality distinguishing violent sexual from other violent offenders, with youth having greater negative emotionality and less effortful control being non-sexual violent offenders. Homicide offenders were more likely to be older, male and had histories of gang membership and weapon/firearm offending than other violent offenders, and evidenced greater negative emotionality than violent sexual offenders.

Originality/value
The differences across violent youthful offender subtypes suggest heterogeneity among violent offenders with distinct correlates more predictive of some subtypes than others. Additionally, the temperament constructs of effortful control and negative emotionality are useful in distinguishing violent offender subtypes, which points toward differing intervention/treatment strategies.
The interplay between early language and temperamental difficulties in the prediction of severe antisocial behavior among males
Authors: Jackson Dylan B. 
Published: April 2017

PurposeThe purpose of this paper is to examine whether early language deficits increase the risk of severe antisocial behavior among male children, and whether this association varies as a function of negative temperament during infancy.Design/methodology/approachData are derived from the Early Childhood Longitudinal Study, Birth Cohort. Both survey methods and direct observations were employed to obtain the data. Logistic regression was used to examine the research questions at hand.FindingsMale children with oral vocabulary and grammatical/syntactic deficits during the toddler years exhibited more frequent antisocial behavior across home and school settings during kindergarten, relative to boys without language deficits. However, this relationship was limited to males who manifested negative temperament/affect during their infancy, as reported on by both parents and independent raters.Originality/valuePrior research on language, temperament, and antisocial behavior has generally overlooked the potential for these early-life risk factors for subsequent offending to interact with each other. The findings of the present study suggest that early intervention and prevention efforts should account for ways in which individual temperamental differences can structure behavioral responses to cognitive challenges.