bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poly-Xaa Sequences in Proteins - Biological Role and Interactions with Metal Ions: Chemical and Medical Aspects
Authors: Watly Joanna , Hecel Aleksandra , Kolkowska Paulina , Kozlowski Henryk , Rowinska-Zyrek Magdalena 
Published: May 2017

Background:
The understanding of the bioinorganic and coordination chemistry of
metalloproteins containing unusual poly-Xaa sequences, in which a single amino acid is repeated
consecutively, is crucial for describing their metal binding-structure-function relationship, and
therefore also crucial for understanding their medicinal potential. To the best of our knowledge,
this is the first systematic review on metal complexes with polyXaa sequences.

Methods:
We performed a thorough search of high quality peer reviewed literature on poly-Xaa
type of sequences in proteins, focusing on their biological importance and on their interactions
with metal ions.

Results:
228 papers were included in the review. More than 70% of them discussed the role of
metal complexes with the studied types of sequences. In this work, we showed numerous medically
important and chemically fascinating examples of possible ‘poly-Xaa' metal binding sequences.

Conclusion:
Poly-Xaa sequences, in which a single amino acid is repeated consecutively, are often
not only tempting binding sites for metal ions, but very often, together with the bound metal,
serve as structure determinants for entire proteins. This, in turn, can have consequences for the
whole organism. Such sequences in bacterial metal chaperones can be a possible target for novel,
antimicrobial therapeutics.
La inserción socioeconómica y territorial de los migrantes aymaras en la ciudad de El Alto (Bolivia): un análisis de las dinámicas urbana y laboral
Authors: Diaz Mariela Paula 
Published: May 2017

Este artículo analiza la apropiación urbana de los migrantes aymaras residentes en dos barrios de la ciudad de El Alto: “El Porvenir I” (periferia) y “16 de Julio” (centro), y su relación con la dinámica laboral. En el barrio periférico ocurre la configuración de territorios rururbanos, donde los migrantes empobrecidos mantienen un hilo de continuidad con sus comunidades. Para llevar a cabo esta investigación, se realizaron entrevistas semi-estructuradas en profundidad a la población migrante y se aplicó una encuesta a miembros de 100 hogares en total. También se destaca la observación no participante de las actividades de la vida cotidiana.
Pemetaan kualitas permukiman dengan menggunakan penginderaan jauh dan SIG di kecamatan Batam kota, Batam
Authors: Farizki M. , Anurogo Wenang 
Published: May 2017

Permukiman adalah bagian dari lingkungan hidup yang berfungsi sebagai lingkungan tempat tinggal. Kondisi dari suatu permukiman sangat mempengaruhi kelangsungan kehidupan dan kesejahteraan makhluk hidup di permukiman tersebut. Untuk mengetahui kualitas permukiman di Kecamatan Batam Kota dibutuhkan parameter-parameter penentu yang di interpretasi dari citra resolusi tinggi (Google Earth). Untuk membantu proses analisis dengan memanfaatkan teknologi penginderaan jauh dan untuk pemetaan menggunakan software SIG. Metode yang digunakan adalah metode pengharkatan (scoring), tumpang susun (overlay). Hasil dari overlay tersebut adalah peta kualitas permukiman di kecamatan Batam Kota, Kota Batam. Dari penelitian ini dapat diketahui bahwa permukiman di Kecamatan Batam Kota dengan kualitas baik dengan luas 476.88 Ha, kualitas sedang dengan luas 650 Ha, dan kualitas buruk dengan luas 48.89 Ha. Dari hasil tersebut permukiman di Kecamatan Batam Kota didominasi oleh permukiman dengan kualitas sedang. The neighborhood is part of the environment that serves as a neighborhood residence. The condition of a settlement extremely affects to the continuity of life and the well-being of living creatures in the neighborhood. To find out the quality of the neighborhoods in districts of Batam City required parameters in determining the interpretation of high-resolution images (Google Earth). To help the analysis process by making use of remote sensing technology for the mapping, and using software SIG. The Method is using score (scoring), and stack bundles (overlay). The result of the overlay mapped quality neighborhoods in districts of Batam city, Batam city. From this research it can be known that settlements in Batam City with good quality with extensive 476.88 Ha, better quality with an area of 650 Hectares, and bad quality with extensive 48.89 Ha. The results of the neighborhoods in districts of Batam City are dominated by the neighborhoods with better quality.
Pemanfaatan Citra Landsat 8 Multitemporal dan Model Forest Canopy Density (FCD) untuk Analisis Perubahan Kerapatan Kanopi Hutan di Kawasan Fakultas Geografi Universitas Gadjah Mada Gunung Kelud, Jawa Timur
Authors: Himayah Shafira , Hartono Hartono , Danoedoro Projo 
Published: May 2017

Penginderaan jauh memiliki keunggulan dalam hal resolusi temporal yang dapat dimanfaatkan untuk meneliti perubahan suatu obyek dalam waktu yang berbeda. Hutan Gunung Kelud mengalami perubahan setelah erupsi tahun 2014. Perubahan tersebut dapat dianalisis dengan memanfaatkan teknologi penginderaan jauh melalui citra multitemporal. Penelitian ini bertujuan untuk mengkaji kemampuan citra Landsat 8 multitemporal dan Forest Canopy Density (FCD) untuk perubahan kerapatan kanopi di Hutan Lindung Gunung Kelud sebelum dan sesudah erupsi tahun 2014.Citra penginderaan jauh yang digunakan adalah citra Landsat 8 perekaman 26 Juni 2013 dan 4 September 2015. Metode yang digunakan adalah pemodelan FCD yang menghasilkan kerapatan kanopi per piksel. Hasil pemodelan FCD kemudian digunakan untuk menganalisis perubahan kerapatan kanopi setelah erupsi. Berdasarkan penelitan ini didapatkan hasil bahwa citra Landsat 8 dapat dipergunakan untuk mengetahui kerapatan kanopi Hutan Lindung Gunung Kelud sebelum dan setelah erupsi dengan masing-masing akurasi sebesar 83,73% dan 81,14%. Terjadi perubahan luas kerapatan kanopi setelah erupsi, dimana terdapat 8833,95 Ha hutan yang mengalami penurunan kerapatan kanopi, sedangkan hutan dengan kerapatan kanopi yang tetap adalah seluas 2149,38 Ha, dan hutan yang mengalami peningkatan kerapatan kanopi adalah seluas 1643,31 Ha. Remote sensing has an advantage in terms of temporal resolution that can be exploited to examine the changes of an object in different times. Gunung Kelud Forest is changing after the eruption in 2014. The changes can be analyzed by utilizing remote sensing technology through multitemporal imagery. This study aims to examine the capabilities of Landsat 8 multitemporal and Forest Canopy Density (FCD) images for changes in canopy density in Kelud Protection Forest before and after the eruption in 2014. Remote sensing imagery used is Landsat 8 image recording June 26, 2013, and September 4, 2015, The method used is FCD modeling that produces a density of the canopy per pixel. FCD modeling results are then used to analyze changes in density of the canopy after the eruption. Based on this research, it can be concluded that Landsat 8 image can be used to determine the density of canopy of Kelud Protection Forest before and after eruption with 83.73% and 81.14% accuracy respectively. There was a change in the area of the canopy density after the eruption, where there was 8833.95 ha of forest that experienced a decrease in canopy density, whereas forests with fixed canopy densities were 2149.38 Ha, and forests with an increase in canopy density were 1643.31 Ha.
DEXMEDETOMIDINE VERSUS ORAL PREGABALIN TO ATTENUATE HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND OROTRACHEAL INTUBATION: A COMPARATIVE STUDY
Authors: Samal Soumya 
Published: May 2017

INTRODUCTION: The airway instrumentation of direct laryngoscopy and tracheal intubation are powerful noxious stimuli that should be attenuated by appropriate premedication, smooth induction and rapid intubation. The present study compared the efficacy intravenous dexmedetomidine and oral pregabalin premedication for attenuation of haemodynamic pressor response to laryngoscopy and intubation.METHODS: A total of 60 patients of age group 20-50 years scheduled for elective surgeries under general anaesthesia with ASA physical status I and II were divided into two groups each of 30. Group D received intravenous dexmedetomidine 1mcg/kg over 10 minutes before induction and group P received oral pregabalin 150 mg one hour prior to intubation. Parameters observed were heartrate and mean arterial pressure at baseline, after induction, immediately after intubation and then 5, 10, 15 and 30 minutes thereafter.RESULTS: Attenuation of heartrate in group dexmedetomidine (78.12 ± 10.0 / min) immediately after intubation was statistically significant than group pregabalin (89.76 ± 10.45 / min). Mean arterial pressure significantly (p < 0.05) decreased after intubation with dexmedetomidine. As compared to oral pregabalin, attenuation of heartrate and mean arterial pressure was statistically significant till 30 minutes after intubation with intravenous dexmedetomidine. CONCLUSION: Intravenous dexmedetomidine 1µg/kg is more effective than oral pregabalin 150 mg in attenuating hemodynamic response to laryngoscopy and orotracheal intubation.KEYWORDS: Hemodynamic pressor response, Laryngoscopy, Intubation, Intravenous dexmedetomidine, Oral pregabalin.
ACTIVITY OF POLYHERBAL EXTRACT AGAINST BACTERIA CAUSING SKIN INFECTIONS IN DIABETIC PATIENTS.
Authors: Kota Chaitanya Sravanthi , Kota Chaitanya Sravanthi , Kota Chaitanya Sravanthi 
Published: May 2017

Objective : - The objective of this study is to evaluate antibacterial activity of Polyherbal extract on few microorganisms causing skin infections in most of the diabetic patients .Methods : - Methanolic Polyherbal extract was prepared from Acacia ferruginia (bark & fruit), Chloroxylon swietenia (bark, leaf, root), Casearia elliptica (bark), Terminalia alata (root, leaf). The preliminary phytochemical analysis was performed to identify the major phytoconstituents in the extract. Polyherbal extract was evaluated for antibacterial activity against bacteria like Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, Proteus species, Klebsiella species causing skin infections , diabetic foot infections in diabetic patients. In-vitro method of agar diffusion disc method was used for the evaluation of antibacterial activity through zone of inhibition. The standard drug used was Gentamicin. Minimum Inhibitory Concentration (MIC) of the extract was done using broth dilution method.Results: The polyherbal extract showed good antibacterial activity. The standard drug used was Gentamicin. The Methanolic Polyherbal extract showed potent activityon all the selected microorganisms. The Polyherbal extract was active against Pseudomonas aeruginosa (2.57 + 0.39) and E.coli (2.92 + 0.29) when compared with standard. The polyherbal extract showed potent activity on Bacillus subtilis and Proteus vulgaris.Conclusion : The polyherbal extract showed broad spectrum activity by being active against gram positive and gram negative microorganisms providing the scope for further analysis as a antibacterial preparation for the skin infections in diabetes patients. Keywords: Antibacterial activity, skin infections, diabetes, Polyherbal Extract, Agar diffusion disc.
Biogenic silver nanoparticles mediated by Broussonetia papyrifera: anticancer and antimicrobial activity against pathogenic organisms
Authors: N Vasanth , G Melchias , P Kumaravel 
Published: May 2017

Objective: To evaluate the potential aspects of biologically synthesized silver nanoparticles mediated by Broussonetia papyrifera against the human pathogens. The same is acknowledged to have high efficiency in the field of Pharmaceutical industry.Methods: The 1Mm of AgNO3 is prepared and mixed with appropriate volume of plant extract and reaction volume was made up to 100 ml. the physical characterization of AgNPs was done. The anti-microbial activity was done against dread pathogens. Cytotoxic activity of the AgNPs was investigated against breast and lung cancer cell lines.Results: The FESEM and EDAX of the microscopic level showed the particle surface measurements around 44 nm to 50 nm. The XRD investigations are being an evidence for the crystalline structure of the AgNPs with 30 nm. The bacterial pathogen Rhodococcus rhodochrous showed the maximum zone of inhibition (11.8±0.447). The A549 human lung cancer cell line and MCF-7 human breast cancer cell line were tested against the toxicity of AgNPs. The toxicity of AgNPs was valued and corresponding IC50 for Lung cancer (A549) is 12.95± 0.05 µg/mL and Breast cancer (MCF-7) is 10.75± 0.05 µg/mL respectively.Conclusion: The present research denotes that biomolecules derived AgNPs have larger impact as antimicrobials in the biomedical field. Since the aggressive chemicals are not involved AgNPs production, these bio-substances can of alternative medicine to resistant once. The in-vitro experiments exhibits the therapeutic effect of this AgNPs based on the ambient concentration on the process.KEYWORDS: Cancer activity, Antimicrobial agents, Resistance, Silver nanoparticles.
EFFECT OF SUB-CHRONIC EXPOSURE TO CHROMIUM ON HAEMATOLOGICAL AND BIOCHEMICAL PARAMETERS OF MALE ALBINO RAT
Authors: Saha Jahnabi , Choudhuri Soma , Choudhuri Dipayan 
Published: May 2017

Objectives : Exposure to chromium, the transition element found in many compounds of earth’s crust, leads to various health hazards including cancer, dermatitis, damage of liver and kidneys and reproductive toxicity in both male and female. Toxic effect of chronic exposure to chromium at low environmentally relevant dose is recently recognized and less studied. In the present study, we evaluated the effect of sub-chronic exposure to low doses of chromium VI (K2Cr2O7) on various haematological and biochemical parameters in male albino rats.Methods : Male albino rats (160±10 gm) received 1/25, 1/50 and 1/100 of reported oral LD50 dose of chromium VI (K2Cr2O7) for 90 consecutive days. After treatment, the blood was collected for analysis of various haematological and biochemical parameters.Results : Exposure to chromium VI at 1/25 LD50 dose caused decrease in body weight gain and reduction in the weight of the reproductive organs along with increase in the weight of liver and kidney. Numbers of red blood cells, white blood cells, platelets and haemoglobin concentration reduced with increase in clotting time. The total sperm count and motility was also reduced in exposed rats. There was decrease in plasma protein and albumin concentration, with increase in plasma glucose and cholesterol level. The activity of enzyme alanine aminotransferase and enzyme aspertate aminotransferase was stimulated in treated rats.Conclusion : The results of the present study revealed that chronic low dose exposure to chromium VI resulted in a toxic effect in experimental male albino rats. Keywords: Chromium VI (K2Cr2O7), Haematological parameters, Biochemical parameters.
ORAL CAVITY SQUAMOUS CELL CARCINOMA IN A CASE OF IFAP SYNDROME WITH CHRONIC MYELOID LEUKEMIA ON LONG TERM HYDROXYUREA: A RARE PRESENTATION
Authors: Singh Anshul , P Uday Kumar , Reddy S Anusha , Yathiraj Prahlad H , Vidyasagar Mamidipudi S 
Published: May 2017

We report a case of a patient in his early 30s’ who presented with an ulcero-proliferative growth over the left buccal mucosa , he was also on treatment for CML in blast crisis on Hydroxyurea and a known case of Ichthyosis Follicularis, Alopecia, and Photophobia (IFAP) syndrome. Though a working diagnosis of chloroma / Hydroxyurea induced erosive Lichen planus was suspected, the histopathological examination of the lesion was suggestive of Squamous cell Carcinoma. He was subsequently planned for palliative radiotherapy .
Rancang Bangun Sistem Informasi Servis Oli Sepeda Motor Menggunakan Odometer Berbasis LBS
Authors: Santana Renda Arya , Risqiwati Diah , Sari Zamah 
Published: May 2017

Waktu servis dapat diketahui melalui mengkonversi putaran roda kendaraan menjadi jarak tempuh. Penggunaan sensor magnet Reed Switch untuk menghitung putaran roda sepeda motor, kemudian Mikrokontroller digunakan sebagai pengolah data putaran roda menjadi jarak tempuh. Apabila perhitungan jarak tempuh telah mencapai batas untuk servis oli, maka akan diberikan suatu peringatan berupa suara menggunakan buzzer. Sistem ini juga dilengkapi dengan button reset untuk me-reset perhitungan jarak tempuh dan sd card yang digunakan untuk menyimpan data jarak tempuh. Aplikasi LBS dapat menentukan posisi pengguna maupun bengkel-bengkel resmi Honda yang telah terintegrasi. Dengan kombinasi ini, aplikasi LBS Bengkel akan mencari rute untuk menghubungkan posisi pengguna dengan bengkel motor serta memanfaatkan servis di google yang sudah disertakan layer traffic sehingga pengguna dapat memilih bengkel yang sesuai dengan keinginannya. Dari hasil aplikasi LBS bengkel yang telah dibuat, aplikasi dapat mendaftarkan servis sepeda motor ke bengkel-bengkel yang terintegrasi. Aplikasi tersebut memapu melakukan proses pencarian lokasi bengkel terdekat di sekitar pengguna dan menunjukkan rute dari lokasi pengguna ke bengkel tujuan menggunakan API google map. Kata kunci: Location Based Service (LBS), Mikrokontroler, Bengkel, Reed Switch, Buzzer
Re-radicalizando la justificación
Authors: Moe-Lobeda Cynthia 
Published: May 2017

Las creencias de Lutero en cuanto a la justificación se originan en la resistencia contra las ideas políticas y culturales; asimismo, en los arreglos de poder que impidieron a la gente experimentar el don de Dios, su amor incondicional. ¿Cómo puede ser que una tradición con tales causas radicales y liberadoras se ha convertido en cómplice del poder político y cultural que también impide a la gente confiar en el amor incondicional de Dios? La autora argumenta que las tradiciones luteranas han tendido que afirmar la parte «segura» de los descubrimientos claves de Lutero, mientras ignoraron la parte «peligrosa». Este artículo enfatiza los aspectos «peligrosos» a menudo ignorados. En su conjunto dan aliento a la resistencia contra arreglos opresivos de poder económico, político y cultural.
¿Significa eso que abrogamos la Torá por la confianza? Ro 3.28-31 y la biblia en lengua justa
Authors: Crüsemann Marlene 
Published: May 2017

M. Crüsemann explica los problemas de la traducción de Ro 3.28 en la Bíblia en lengua justa, choris ergon nomou (sin obras de la ley). Este versículo ha tenido un fuerte impacto en la tradición de la Reforma, ya que a menudo la Torá judía es pensada como de poca importancia para la cristiandad. Pero es necesario estudiar los conocimientos de Pablo respecto a la Torá en el contexto del Imperio romano. Sus estructuras poderosas enseñaron a Pablo el dominio terrorizante del pecado que impidió vivir según la Torá de Dios. Sin embargo, la gente experimenta una liberación mediante la confianza en Jesús como Mesías. Esa justificación por la fe habilita a la gente para vivir según los mandamientos de la Torá. Si la gente practica la Torá, la justicia de Dios va a florescer en el mundo. De ahí que Pablo no condena la Torá, sino que la fortalece.
Un nuevo comienzo: Revista NOVA Publicación Científica en Ciencias Biomédicas
Authors: Yunda Perlaza Leonardo 
Published: May 2017

Desde el año 2002, la Universidad Colegio Mayor de Cundinamarca (Unicolmayor), se propuso aportar a la construcción del conocimiento y al fortalecimiento de la comunidad científica y académica del país en el áreade las ciencias biomédicas con la creación de la revista NOVA. Hoy, 11 años después, se puede decir con toda certeza que ese propósito se ha cumplido y la universidad continuará por este camino que se ha abierto. Las áreasbiológicas y médicas se han beneficiado de la producción de artículos inéditos, producto de trabajos originales que son publicados en Nova, la cual ha sido editada por la misma universidad desde su comienzo, vincu
Efecto de la rehabilitación pulmonar en la calidad de vida y la capacidad funcional en pacientes con secuelas de tuberculosis
Authors: Betancourt Peña Jhonatan , Muñoz Erazo Beatriz Elena , Hurtado Gutiérrez Hugo 
Published: May 2017

Describir el impacto de un programa de rehabilitación pulmonar en pacientes con secuelas de TB pulmonar. Método. Estudio cuasiexperimental en once pacientes en un programa de rehabilitación pulmonar con ejercicio continuo, fortalecimiento muscular y educación durante ocho semanas. Se evaluó antes y después el IMC, disnea, test de caminata de 6 minutos, ansiedad, depresión y calidad de vida relacionada con la salud; la t pareada se utilizó para analizar las medias. Resultados. Once pacientes terminaron el programa de rehabilitación pulmonar. La edad media era de 45.4 años ± 21.7. 8 pacientes eran del género masculino. Al culminar el programa se encontró un incremento significativo en la distancia recorrida en el 6MWT con una diferencia media de 110.2 metros ± 112.5 (p=0.009). La calidad de vida relacionada con la salud SGRQ tuvo disminución significativa en la puntuación total, diferencia media 6.7 ± 8.3 (p=0.02), no se encontraron diferencias significativas en los otros dominios del cuestionario. Existe buena tolerancia al ejercicio de pacientes con secuelas de TB en un programa de rehabilitación pulmonar, los fisioterapeutas deben considerar la diferencia de la distancia recorrida en el test de caminata de 6 minutos al inicio y final del programa como una variable confiable relacionada con el incremento de la capacidad funcional.
Low-intensity pulsed ultrasound reduces periodontal atrophy in occlusal hypofunctional teeth
Authors: Kasahara Yuki , Usumi-Fujita Risa , Hosomichi Jun , Kaneko Sawa , Ishida Yuji , Shibutani Naoki , Shimizu Yasuhiro , Okito Asuka , Oishi Shuji , Kuma Yoichiro , Yamaguchi Hiroyuki , Ono Takashi 
Published: May 2017

ABSTRACT

Objective:
To clarify whether low-intensity pulsed ultrasound (LIPUS) exposure has recovery effects on the hypofunctional periodontal ligament (PDL) and interradicular alveolar bone (IRAB).

Materials and Methods:
Twelve-week-old male Sprague-Dawley rats were divided into three groups (n = 5 each): a normal occlusion (C) group, an occlusal hypofunction (H) group, and an occlusal hypofunction group subjected to LIPUS (HL) treatment. Hypofunctional occlusion of the maxillary first molar (M1) of the H and HL groups was induced by the bite-raising technique. Only the HL group was irradiated with LIPUS for 5 days. The IRAB and PDL of M1 were examined by microcomputed tomography (micro-CT) analysis. To quantify mRNA expression of cytokines involved in PDL proliferation and development, real-time reverse transcription quantitative PCR (qRT-PCR) was performed for twist family bHLH transcription factor 1 (Twist1), periostin, and connective tissue growth factor (CTGF) in the PDL samples.

Results:
Micro-CT analysis showed that the PDL volume was decreased in the H group compared with that of the C and HL groups. Both bone volume per tissue volume (BV/TV) of IRAB was decreased in the H group compared with that in the C group. LIPUS exposure restored BV/TV in the IRAB of the HL group. qRT-PCR analysis showed that Twist1, periostin, and CTGF mRNA levels were decreased in the H group and increased in the HL group.

Conclusion:
LIPUS exposure reduced the atrophic changes of alveolar bone by inducing the upregulation of periostin and CTGF expression to promote PDL healing after induction of occlusal hypofunction.