bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASSESSMENT OF KNOWLEDGE, ATTITUDES AND PRACTICES ON RHEUMATIC HEART DISEASE AMONG CARDIAC PATIENTS IN AMRAN CITY, YEMEN
Authors: Ali Abduallah AA , Altholey Reham MA , Bakri Waheed MA , Shayea Yaqup AS , Abbas Mohammed AN , Aklan Abdulnaser SA , Alseraji Ziad MA 
Published: September 2024

Background: All three layers of the heart—the pericardium, myocardium, and endocardium (including the valves)—may sustain irreversible damage as a result of rheumatic heart disease (RHD). Rheumatic heart disease is the result of valvular damage caused by an abnormal immune response to group a streptococcal infection, usually during childhood. The study aims to achieve the assessment of Knowledge, Attitudes and Practices (KAP) on rheumatic heart disease among cardiac patients in Amran city, Yemen.
Method: The descriptive analytical method was used. The questionnaire was used as a tool for collecting data the research sample was (121) of those accompanying rheumatic heart patients in clinics and medical centers in the city of Amran, and they were selected in a simple random method. The data was analyzed and processed statistically using the Statistical Package for the Social Sciences program (SPSS) and many statistical methods, and after conducting the data analysis process and testing the study hypotheses.
Result: The study found that heart patients in Amran have knowledge about rheumatic heart disease causes and symptoms, but lack knowledge about risk factors and disease history. Most suffer from arthritis and do not practice regular exercise. There were no significant differences in opinions about rheumatic heart disease and risk factors among heart patients due to variables like gender, age, education, and living conditions. Rural residents showed statistically significant differences.
Conclusions: The study reveals that patients with rheumatic heart disease have the highest knowledge about the causes and symptoms, but also the risk factors associated with the disease. The knowledge of the disease's history is the most common, followed by rheumatic fever. Arthritis is the most common risk factor. The study found no significant differences in opinions among heart patients in Amran, but significant differences were observed in rural residents' opinions due to factors like gender, age, and living conditions.

Peer Review History:
Received 13 May 2024; Reviewed 14 July 2024; Accepted 22 August; Available online 15 September 2024
Academic Editor: Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dina Abd Elfattah Eldakhs, Pharos university (PUA), Egypt, dina_eldakhs@yahoo.com
Prof. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye
PREVALENCE OF PAROTID TUMORS AMONG YEMENI PATIENTS IN SANA'A CITY, YEMEN
Authors: Al-Kibsi Taghreed Ahmed M , Qirshi Heba Gamal Moqbel Ali Al , Al-Shamahy Hassan Abdulwahab 
Published: September 2024

Background and aims: Parotid gland tumors (PGT) are a moderately scarce group of tumors with a broad range of histopathological manifestations and clinical characteristics. To date, most epidemiological studies on salivary gland tumors including PGT are limited in Yemen and this is one of the first studies, so the aim of the study was to determine the prevalence of different tumors affecting the parotid glands and the effect of age and sex on their distribution.
Methods: Epidemiological information as well as demographic data, anatomical site, and histological analysis of PGT were analyzed. The data analyzed included age, sex, site, and histological diagnosis. Data were collected from all histopathological centers covering the majority of Sana'a city between 2019 and 2023.
Results: A total of 284 cases- 69% benign and 31% malignant tumors were examined. Both benign and malignant tumors showed a little male inclination (52.5%) and a peak occurrence between the third and fifth decade. Malignant tumors make up 31% of patients, while benign tumors make up 69%. Mucoepidermoid carcinoma (36.4%) and adenoid cystic carcinoma (11.4%) are two common malignant tumor types. Benign parotid tumors include pleomorphic adenoma (71.4%) and Warthin tumors (11.2%) of benigns. Other malignants and benigns are less frequent.
Conclusions: This study presents the first prospective study to date to analyze PGT data from health centers spread across Sana'a city. These results should serve the same as the basis for prospect studies assessing the epidemiological geography of these tumors in Sana'a in particular and Yemen in general.

Peer Review History:
Received 18 May 2024; Reviewed 12 July 2024; Accepted 23 August; Available online 15 September 2024
Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr
Average Peer review marks at initial stage: 6.5/10
Average Peer review marks at publication stage: 7.5/10
Reviewers:
Asmaa Ahmed Mohamed Ahmed Khalifa, Pharos University, Alexandria, Egypt, asmaa.khalifa@pua.edu.eg
Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com
THE IMPACT OF COLLABORATIVE CARE ON COST OF TREATMENT FOR THE MANAGEMENT OF HYPERTENSION- A SYSTEMATIC REVIEW
Authors: Shahid Sara , Qamar Areej , Ali Umar , Ali Sadaqat , Hameed Muhammad Salman , Ashraf Syed Muneeb , Nasir Arooj , Qamar Mahdeem , Ayesha Maryam , Bajwa Amna , Iqbal Muhammad Zahid 
Published: September 2024

Introduction: For evaluation of the long term costs and benefits of physician-pharmacist collaboration associated with physician management for the treatment of essential hypertension. Around the world the major cause of death is hypertension. It is an incurable condition that requires proper therapeutic regimens for its life-long management. Due to this, hypertension therapy can be financially burdensome to the patient, and the rates of non-compliance are increased.
Aims and Objectives: To observe the results of collaborative, clinical, and interventive approaches to hypertension management, on the cost-effectiveness of therapy, this study aimed to collect and compare cost information on hypertension management, mortality, and morbidity across different countries and cost groups. Using this information, future healthcare expenses can be better planned; for example, by initial emergency response or by changing the way money is distributed. This will lead to more high-pressure jobs. Therefore, it will be more costly to control blood pressure.
Method: A systematic review was conducted using 6 major electronic databases that investigated the influence of collaborative care upon healthcare expenses in hypertensive patients and hypertension therapy costs, before and after the intervention of medical personnel, was observed.
Conclusions: It was concluded that interventions provided by the collaboration of medical personnel, in the management of hypertension, made the therapy more cost-effective and hence the rate of patient compliance and adherence to the therapy were increased.

Peer Review History:
Received 18 May 2024; Reviewed 11 July 2024; Accepted 26 August; Available online 15 September 2024
Academic Editor: Dr. Tamer Elhabibi, Suez Canal University, Egypt, tamer_hassan@pharm.suez.edu.eg
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Ogbonna B. Onyebuchi, Nnamdi Azikiwe University, Awka, Nigeria, summitpharm@yahoo.com
Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com
TREATMENT OUTCOMES IN PCOS (POLYCYSTIC OVARIAN SYNDROME)-RELATED INFERTILITY
Authors: Ibrahim Aminath Efa , Shareef Fathimath Ina , Yazdhan Ahmed , Shabin Ahmed , Ali P. Shaik Syed , Ahmad Md. Parwez 
Published: September 2024

Polycystic ovarian syndrome (PCOS) is one of the underdiagnosed endocrine disorders found to be prevalent among females in the reproductive age group. PCOS effects on an average 8-13% of reproductive aged women, globally. This condition is responsible for causing distress physiologically and psychologically paving the way for a poor quality of life. One of the devastating complications of PCOS is infertility. At present, there is no treatment for PCOS but could be managed by alternate options such as lifestyle modification to in-vitro fertilization. The primary objective of this review article is to analyze the outcomes of certain pharmacological treatment options such as clomiphene citrate which is a selective estrogen receptor modulator, Letrozole an aromatase inhibitor, and gonadotropins for PCOS-related infertility. Clomiphene citrate binds to estrogen receptors indirectly increasing the gonadotropins. Studies confirm a 35-40% successful outcome. Letrozole similarly increases gonadotropins by indirectly decreasing estrogen. A notable increase in the successful outcome was observed with both clomiphene citrate and letrozole, with almost near similar results. The pregnancy outcome was approximately 40% with clomiphene citrate, while letrozole showed 50%. Notably, more side effects were observed in the administration of clomiphene citrate compared to letrozole. Human menopausal gonadotropin (hMG) and recombinant follicle-stimulating hormone (FSHr), that are gonadotropins, were used as they are directly responsible for the maturation of follicles and ovulation itself. The use of gonadotropins increased the pregnancy rate outcome to 20 -30 %, albeit with the risk of multiple births. Furthermore, we have discussed why letrozole and clomiphene citrate are used as the primary therapy compared to gonadotropins.

Peer Review History:
Received 22 May 2024; Reviewed 14 July 2024; Accepted 23 August; Available online 15 September 2024
Academic Editor: Dr. Rola Jadallah, Arab American University, Palestine, rola@aauj.edu
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com
Dr. Ogbonna B. Onyebuchi, Nnamdi Azikiwe University, Awka, Nigeria, summitpharm@yahoo.com
THE ANTICOAGULATION STRATEGIES FOR MANAGEMENT AND PREVENTION OF STROKE IN NEUROLOGICAL PRACTICE
Authors: Measar Mujahed , Alyahawi Ali 
Published: September 2024

Strokes are categorized as either ischemic or hemorrhagic and the specific interventions will be based on the type of stroke. About 13% of stroke is hemorrhagic and 87% is ischemic. Transient Ischemic Attacks require emergency intervention to decrease the threat of stroke, which is thought to be maximum within the first few days after TIA. Anticoagulants play a major role in the primary and secondary prevention of ischemic strokes.
The optimal timing of anticoagulants initiation or resumption inpreventing and managing ischemic strokes is very important. This article will explore certain controversies surrounding this issue, while also highlighting the benefits of antithrombotic therapy used in prevention of ischemic strokes in antiphospholipid antibody syndrome (APS), atrial fibrillation, prosthetic heart valve, cancer, and vascular disorders. Aggressive local and regional efforts to organize stroke care and greater use of evidence-based recommendations may help improve outcomes.

Peer Review History:
Received 16 May 2024; Reviewed 11 July 2024; Accepted 24 August; Available online 15 September 2024
Academic Editor: Essam Mohamed Eissa, Beni-Suef University, Egypt, dressamceutics@yahoo.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Taha A.I. El Bassossy, Medicinal and Aromatic Plants Department, Desert Research Center, Cairo, Egypt, tahachemist2008@gmail.com
Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com
DETERMINATION OF SOME PHARMACOKINETIC PROPERTIES OF ARTEMETHER-LUMEFANTRINE GRANULES IN ALBINO RATS
Authors: Ubieko Edwin A. , Ubieko Emmanuel A. 
Published: September 2024

Aim and Objectives: Malaria is an infectious disease that is caused by plasmodium parasites which is rampant in Sahara Africa and children under 5 years of age are highly vulnerable to this infection by malaria. So the need for the formulation of dosage form for this population using naturally occurring excipients to replace imported ones being currently used by our local manufacturing industries in-order to formulate novel, readily available, affordable and effective antimalarial medicine for children.
Methods: Using the local excipients and its hybrid, the formulated artemether-lumefantrine granules for oral suspension were administered to albino rats, blood samples were collected at predetermined time 0, 1.5, 3, 6, 9, 12, 15, 18, 21, and 24 h respectively and drug contents; artemether-lumefantrine were determined within the stipulated period.
Results: Some pharmacokinetic parameters determined were; maximum concentration, Cmax, time to reach the maximum concentration, Tmax, half-life, t1/2, area under the curve, AUC, and mean residence time, MRT, which were for artemether-lumefantrine were 3.9, 3.4, μg/L; 3.2, 6.0 h; 12.5, 14 h; 75.8, 168.5 μg/L.h; 24, 24 h respectively, for the marketed artemether-lumefanthrine granules for oral suspension.4.1, 3.2 μg/L; 1.4, 3.0 h; 3.0, undefined h, 67.0, 65.7 μg/L. h; 18, 18 respectively for hybrid formulated artemether-lumefantrine granules for oral suspension and 3.1, 3.8 μg/L; 2.5, 12.5 h; 4.8, 15 h; 20.2, 281.6 μg/L .h; 18, 18 respectively for the extracted pectin formulated granules.
Conclusion: Optimized formulated artemether-lumefantrine granules were superior to the marketed product in terms of pharmacokinetic values being closer to those of earlier workers.

Peer Review History:
Received 13 May 2024; Reviewed 16 July 2024; Accepted 22 August; Available online 15 September 2024
Academic Editor: Dr. Asia Selman Abdullah, Pharmacy institute, University of Basrah, Iraq, asia_abdullah65@yahoo.com
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id
Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my
COMPARATIVE CURE AND SUPPRESSION EFFICACY OF FORMULATED GRANULES WITH A MARKETED SIMILAR PRODUCT
Authors: Ubieko Edwin A. , Ubieko Emmanuel A. 
Published: September 2024

Aim and Objectives: Malaria, a major global health challenge which makes antimalarial drugs one of the commonly prescribed class of drugs World-wide. The most vulnerable are the children and the women especially the expectant mothers. There is need to develop locally and readily available excipients from natural sources to replace imported ones currently being used by our local manufacturing industries. The purpose of the investigation was to test the formulated granules for oral suspension.
Methods: Some weighed albino rats were infected with Plasmodium berghei, then the standard dose of the artemether-lumefantrine oral suspension formulated, a marketed product, and distilled water were administered ; 4/24 mg artemether-lumefantrine per kg body weight per oral to weighed albino rats. Then, other groups were administered standard dose of different formulated granules, a marketed similar product and distilled water respectively. These treated albino rats were then infected with Plasmodium berghei and blood samples were withdrawn from the tail veins, stained with Giemsa stain and the Plasmodium berghei count for the untreated and treated albino rats were determined.
Results: The percentage clearance and suppression were calculated for the different formulations; pectin and its hybrid formulations, a marketed product and distilled water as a control which were 83.73, 85.2, 74.9 and 2.62, and 83.74, 85.2, 74.22, and 0% for curative and suppressive efficacies respectively.
Conclusions: The investigations revealed that the most effective was the hybrid-formulated granules were closely followed by pectin-formulated granules and the least was the marketed product.

Peer Review History:
Received 17 May 2024; Reviewed 12 July 2024; Accepted 20 August; Available online 15 September 2024
Academic Editor: Dr. Asia Selman Abdullah, Pharmacy institute, University of Basrah, Iraq, asia_abdullah65@yahoo.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id
Dr. Ahmad Abdelsattar El-Ebiary, Tanta University Hospitals, Tanta, Egypt, a.ebiary@med.tanta.edu.eg
Accelerated Longitudinal Glycemic Changes in Relation to Urinary Toxic/Essential Metals and Metal Mixtures Among Mexican Americans Living in Starr County, Texas
Authors: Weiss Margaret C. , Sun Jiehuan , Jackson Brian P. , Turyk Mary E. , Wang Luyu , Brown Eric L. , Aguilar David , Brown Sharon A. , Hanis Craig L. , Argos Maria , Sargis Robert M. 
Published: September 2024

OBJECTIVE
Metal and metalloid exposures (hereafter “metals”) are associated with adverse health outcomes, including type 2 diabetes; however, previous studies were largely cross-sectional or underpowered. Furthermore, underserved racial and ethnic groups are underrepresented in environmental health research despite having higher rates of type 2 diabetes and a greater risk of metal exposures. Consequently, we evaluated continuous glycemic traits in relation to baseline urinary toxic metal, essential metal, and metal mixtures in a cohort of Mexican American adults.

RESEARCH DESIGN AND METHODS
A total of 510 participants were selected based upon self-reported diabetes status and followed over 3 years. Urinary metals were assessed at baseline. Linear mixed-effects models were used to estimate per-month changes in hemoglobin A1c, fasting plasma glucose, and postload glucose in relation to urinary metal levels. Multiple statistical approaches were used to assess the associations between glycemic traits and metal mixtures.

RESULTS
After adjustment, higher urinary levels of arsenic, selenium, copper, molybdenum, nickel, and tin were associated with faster increases in measures of glycemia. The toxic metal mixture composed of arsenic, lead, cadmium, nickel, and tin was associated with faster increases in postload glucose. Using postload glucose criteria, highest versus lowest arsenic was predicted to accelerate conversion of normoglycemia to prediabetes and diabetes by 23 and 65 months, respectively.

CONCLUSIONS
In this underrepresented, high-risk Mexican American population, exposure to toxic metals and alterations in essential metal homeostasis were associated with faster increases in glycemia over time that may accelerate type 2 diabetes development.
Spatial distribution of pediatric cancer patients using Geographic Information System (GIS) across the Philippines
Authors: Oruga Myra Dela P. , Garcia Primo G. , Cajucom Loyda A. , Ramos Rita C. , Ridulme Queenie R. , Jesus Ronaldo De , Alcazar Bryan , Vinas Ma Joanna , Manago Raymund K. , Fuentes Raya K. 
Published: September 2024

Background: Every year, many children around the world get cancer, and this is a severe health problem. The Philippines is one such country where childhood cancer is a leading cause of death. This study uses unique maps (Geographic Information Systems or GIS) to examine these young cancer patients' locations. By doing this, we hope to find areas with more cases and see if children in those areas have easy access to the medical care they need.
Methods: Methods involved primary and secondary data collection, including surveys and hospital records, with geospatial data analyzed using QGIS 3.4 Madeira. The study focuses on four Department of Health (DOH) tertiary hospitals: Philippine Children Medical Center (PCMC), Bicol Regional Training and Training Hospital (BRTTH), Southern Philippines Medical Center (SPMC), and Vicente Sotto Memorial Medical Center (VMMC) Participants from significant regions contributed to the study.
Results: Results indicate that cancer centers, notably the primary children’s hospital, cater to patients from far-reaching areas, causing them to consult distant hospitals despite accessible alternatives. Nearly all (around 92.5%) patients seek care at specialized hospitals, even though only a small proportion (roughly 12.3%) live close to such facilities. Instead, 37.3% reported the closest health facility (within 10 kilometers) is a secondary government hospital, increasing the burden on patients with additional travel and non-medical costs.
Conclusions: The study concludes that pediatric cancer patients face challenges accessing healthcare facilities, necessitating alternative methods like telemedicine and mobile clinics. The findings underscore the need for improved healthcare infrastructure and human resources to address the burdens faced by these patients.
culture of caring for low birth weight infants at home after treatment: An ethnographic study from Indonesia
Authors: Rahayuningsih Sri Intan , Rustina Yeni , Afiyanti Yati , Eryando Tris 
Published: September 2024

Background: Caring for low birth weight (LBW) babies is a challenge for parents, especially after being discharged from the hospital, to continue the care provided by professional nurses. Culture can influence how parents behave and decide to keep babies healthy.
Purpose: This study examined the culture that influences mothers in Aceh, Indonesia, to care for LBW infants at home following hospital treatment.
Methods: This study used an ethnographic design that involved ten participants consisting of mothers who had an LBW infant after receiving hospital care, a grandmother, a midwife, and health cadres. The data were collected using focus group
The predictive value of lncRNA LAMTOR5-AS1 in the recurrence after endoscopic submucosal dissection for early gastric cancer
Authors: Chen Min , Zhou Ye , Luo Maoling , Luo Mingchuan , Wang Yali , Jiang Li 
Published: September 2024

Abstract

Introduction
Endoscopic submucosal dissection (ESD) is effective and widely used in the clinical treatment of early gastric cancer. This study revealed the predictive value of abnormal expression of lncRNA LAMTOR5-AS1 (LAMTOR5-AS1) in the recurrence of early gastric cancer patients after ESD and preliminarily explored the molecular mechanism of LAMTOR5-AS1 in gastric cancer.

Materials and Methods
The level of LAMTOR5-AS1 in the gastric cancer patients (n = 130) and healthy individuals (n = 130) was assessed using RT-qPCR. The ROC curve was established to characterize the diagnostic efficacy of LAMTOR5-AS1 in gastric cancer and recurrence after ESD treatment. Logistic regression analysis was employed to assess the risk factors associated with postoperative recurrence in gastric cancer patients. The regulatory effect of LAMTOR5-AS1 on gastric cancer cells was verified by CCK-8 and Transwell assay.

Results
LAMTOR5-AS1 was upregulated in gastric cancer tissues, and LAMTOR5-AS1 expression in the recurrence group was also enhanced. The area under the curve (AUC) of LAMTOR5-AS1 expression in differentiating gastric cancer patients from healthy controls was 0.9076, while the AUC of LAMTOR5-AS1 expression in predicting recurrence after ESD for early gastric cancer was 0.8147. LAMTOR5-AS1 was confirmed to be an independent risk factor for recurrence after ESD. Silencing of LAMTOR5-AS1 inhibited the biological activity of gastric cancer cells, which was reversed by miR-331-3p inhibitor.

Conclusions
LAMTOR5-AS1 was overexpressed in the recurrence group after ESD, which may be a predictive biomarker in the recurrence of EGC for early gastric cancer patients.