bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase‐2 Inhibitor Rubratoxin A
Authors: Bai Jian , Yan Daojiang , Zhang Tao , Guo Yongzhi , Liu Yunbao , Zou Yi , Tang Mancheng , Liu Bingyu , Wu Qiong , Yu Shishan , Tang Yi , Hu Youcai 
Published: March 2017

AbstractRedox modifications are key complexity‐generating steps in the biosynthesis of natural products. The unique structure of rubratoxin A (1), many of which arise through redox modifications, make it a nanomolar inhibitor of protein phosphatase 2A (PP2A). We identified the biosynthetic pathway of 1 and completely mapped the enzymatic sequence of redox reactions starting from the nonadride 5. Six redox enzymes are involved, including four α‐ketoglutarate‐ and iron(II)‐dependent dioxygenases that hydroxylate four sp3 carbons; one flavin‐dependent dehydrogenase that is involved in formation of the unsaturated lactone; and the ferric‐reductase‐like enzyme RbtH, which regioselectively reduces one of the maleic anhydride moieties in rubratoxin B to the γ‐hydroxybutenolide that is critical for PP2A inhibition. RbtH is proposed to perform sequential single‐electron reductions of the maleic anhydride using electrons derived from NADH and transferred through a ferredoxin and ferredoxin reductase pair.
Synthesis of Functionalized Cyclopentene Derivatives from Vinyldiazo Compounds and Vinylazides through Sequential Copper‐Promoted [3+2] Cycloaddition/Azide Rearrangement
Authors: López Enol , López Luis A. 
Published: March 2017

AbstractThe reaction of vinylazides with alkenyldiazo compounds in the presence of [Cu(CH3CN)4][BF4] provided cyclopentene derivatives with retention of the azide functionality. This process likely involves a sequence comprising: 1) decomposition of the diazo component with generation of a copper alkenylcarbene species; 2) stepwise regioselective [3+2] cycloaddition; 3) allylic azide rearrangement. This method is compatible with a broad range of substrates. We also show that the azide‐containing cycloadducts can be efficiently converted into the corresponding amine and triazole derivatives.
Gold Nanoparticles Supported on Mesoporous Titania Thin Films with High Loading as a CO Oxidation Catalyst
Authors: Akita Shingo , Amemiya Makoto , Matsumoto Takanori , Jikihara Yohei , Nakayama Tsuruo , Hossain Md. Shahriar A. , Kani Kenya , Ishii Daisuke , Islam Md. Tofazzal , Jiang Xiangfen , Fatehmulla Amanullah , Farooq Wazirzada Aslam , Bando Yoshio , Malgras Victor , Yamauchi Yusuke 
Published: March 2017

AbstractIn the present work, 2.4 nm gold nanoparticles (Au NPs) are uniformly dispersed on mesoporous titania thin films which are structurally tuned by controlling the calcination temperature. The gold content of the catalyst is as high as 27.8 wt %. To our knowledge, such a high loading of Au NPs with good dispersity has not been reported until now. Furthermore, the reaction rate of the gold particles is enhanced by one order of magnitude when supported on mesoporous titania compared to non‐porous titania. This significant improvement can be explained by an increase in the diffusivity of the substrate due to the presence of mesopores, the resistance to agglomeration, and improved oxygen activation.
Cardiovascular risk factors in Chiari malformation and idiopathic intracranial hypertension
Authors: Frič Radek , Pripp Are Hugo , Eide Per Kristian 
Published: March 2017

AbstractObjectivesBoth Chiari malformation type 1 (CMI, i.e., the idiopathic caudal ectopy of cerebellar tonsils into foramen magnum) and idiopathic intracranial hypertension (IIH) are characterized by reduced intracranial compliance (ICC) due to disturbed circulation of cerebrospinal fluid (CSF). An increasing body of evidence links cardiovascular disease to CSF circulation disturbances. The aim of this study was to explore whether the prevalence of cardiovascular risk factors in patients with CMI or IIH is higher than in the general population.Materials and MethodsAmong the patients with CMI or IIH treated at our department during the period 2003–2014, we identified those with history of arterial hypertension (AH), myocardial infarction (MI), angina pectoris (AP), or diabetes mellitus (DM). For comparison with a control population, we retrieved information about the prevalence of AH, MI, AP, and DM among participants of the North‐Trøndelag Health Study 3 (HUNT3).ResultsData from 48 CMI and 52 IIH cases were available. Compared to data from the 42,461 individuals participating in the HUNT3, we found increased prevalence of DM in male CMI as well as female IIH cases, and of AH in female IIH cases. Body mass index (BMI) was significantly increased in both female and male IIH cases. Prevalence of MI and AP in the CMI and IIH cohorts was extremely low and therefore not further studied.ConclusionsThis study provided evidence of an increased prevalence of DM in male CMI as well as female IIH cases and of AH in female IIH cases. Although requiring further exploration, these findings point to AH and DM as potential risk factors in the pathophysiology of CMI and IIH.
Olfaction in Parkin carriers in Chinese patients with Parkinson disease
Authors: Wang Ying , Wu Jian‐Jun , Liu Feng‐Tao , Chen Kui , Chen Chen , Luo Su‐Shan , Wang Yi‐Xuan , Li Da‐ke , Guan Rong‐Yuan , Yang Yu‐Jie , An Yu , Wang Jian , Sun Yi‐Min 
Published: March 2017

AbstractBackgroundOlfactory identification was reported to be better among PD (Parkinson disease) patients with Parkin mutations, but previous studies didn't eliminate the interference of other PD related genes on olfaction, and whether olfaction of Parkin mutations patients was better in Chinese population was still unknown.ObjectiveTo assess olfaction function among PD patients with Parkin mutations in Chinese population.Materials and MethodsA total of 226 PD patients with a positive family history or an early‐onset age (<50 years) were enrolled for genetic testing of PD related genes by target sequencing and multiple ligation‐dependent probe amplification. The clinical data including olfactory function test were investigated. Linear regression was performed to adjust for the covariates between all groups.ResultsThere were 68 patients found having a negative result in PD genetic testing and 43 patients carrying homozygous or compound heterozygous Parkin mutations. Among them, 49 PD panel negative patients and 33 PD‐Parkin patients had results of olfactory assessment. PD‐Parkin patients performed significantly better on the Sniffin’ Sticks tests than panel negative patients (8.0 ± 1.7 vs. 5.7 ± 1.9, p < .001), but still worse compared to healthy controls (9.4 ± 1.5, p = .003). These differences persisted after adjusting for confounders.ConclusionsAmong Chinese population, PD‐Parkin patients had relatively preserved olfaction compared to PD panel negative patients after eliminating the interference of other PD related genes, but were still worse than healthy controls.
A case of congestive heart failure caused by secondary hypocortisolism
Authors: Nagura Fukuko , Kodera Satoshi , Hayakawa Naoki , Kushida Syunichi , Kanda Junji 
Published: March 2017

Key Clinical MessageCongestive heart failure caused by secondary hypocortisolism is rare but clinically significant, because its appropriate treatment is effective. Severe hyponatremia with indefinite complaint resembling depression or persisting fever despite antibiotics may be important for establishing this diagnosis.
Weakly coupled multibeam reflector antenna using independent SRR for mutual coupling reduction
Authors: Yang Dae‐Geun , Kim Dang‐Oh , Jang Eun‐Seok , Kim Che‐Young 
Published: March 2017

ABSTRACTThis article presents the design, fabrication, and characterization of a weakly coupled multibeam reflector antenna. To overcome the problems caused by tight coupling, the multibeam reflector antenna used Split Ring Resonators (SRRs) and stubs. The proposed antenna consists of one monopole antenna and four SRRs on top of a dielectric substrate, with a feeding connector at the bottom. The proposed multibeam reflector antenna was designed with an independent architecture to operate at 2.45 GHz. The beam steering is determined based on the switching status of SRRs. This switching methodology allows us for high transmission‐speed operations than the conventional multi‐input multi‐output antennas. In addition, larger amounts of data can be transmitted because of the radiation sum. Also, the proposed antenna did not need an isolator. The measurement results demonstrate that the proposed antenna exhibits beam‐steering and Mirror Image Pattern Pair capabilities successfully. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1006–1009, 2017
Dual polygonal slit square patch with defected ground plane for tri band operation
Authors: Rakesh Kumar P. , Satya Prasad K. , Guruva Reddy A. 
Published: March 2017

ABSTRACTA novel triple‐band square shaped microstrip planar antenna for IMAT2000&WiMAX operation is proposed and investigated. Single probe fed antenna consists of dual polygonal slits cut on top area of the radiating metallic layer and asymmetric dual H‐shaped defected ground structure etched on the bottom area of the metallic ground plane. This letter proposes a major challenge in generating three separate resonances to cover 2.16 GHz IMAT band 3.37 and 5.54 GHz WiMAX band while maintaining overall compact size of 35 × 35 × 3.175 mm3. Structure displays the impedance bandwidth of 3.25% (2.12–2.19 GHz), 2.06% (3.35–3.42 GHz), and 4.18% (5.40–5.63 GHz). Experimental results show that the antenna gives better radiation patterns and good antenna gains of 3.17, 5.0, and 2.2 dBi, respectively over the operating bands. Excellent agreement is obtained between measurements and simulations. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1071–1074, 2017
A low‐cost compact antenna design on a paper substrate for near‐field passive UHFRFID tags
Authors: Sajal Sayeed , Braaten Benjamin D. , Marinov Val , Swenson Orv , Atanasov Yuriy 
Published: March 2017

ABSTRACTA significant cost in the widespread deployment of UHF radio frequency identification (RFID) systems has been the passive RFID tags. To address some of this expense, this paper presents an antenna design for UHF RFID tags that can be printed on inexpensive paper substrates and operate in the near field of the UHF reader. This antenna design is based on meander line miniaturization techniques and open complementary split ring resonator (OCSRR) elements to reduce the amount of conducting material required to manufacture the antenna by 30%. For demonstration purposes, a prototype near‐field UHF RFID tag was manufactured on a paper substrate and the read‐range was measured at 920 MHz. It was shown that useful read‐ranges could be achieved while reducing the overall cost and size of the antenna on the RFID tag. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1052–1056, 2017
A high data rate and high efficiency 60 GHz OOK demodulator in 90 NM CMOS
Authors: Byeon Chul Woo , Park Chul Soon 
Published: March 2017

ABSTRACTThis article presents a 60 GHz on–off keying (OOK) demodulator for short‐range and high‐speed wireless communications. An OOK demodulator consists of a wideband detector and an efficient limiting amplifier. With a gain‐boosting technique, the detector has a voltage responsivity of 5,892 mV/mW and the demodulator has a measured conversion gain of 16 dB for an input power of −20 dBm at 5 Gb/s. With a fabricated test modulator module, the demodulator recovers 7 Gb/s data. With a power consumption of 19.2 mW, the demodulator exhibits an energy efficiency of 2.74 pJ/bit. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1081–1084, 2017
A low profile circularly polarized SIW end‐fire antenna incorporating orthogonally polarized elements
Authors: Cai Yang , Zhang Yingsong , Yang Liu , Qian Zuping 
Published: March 2017

ABSTRACTThis article presents a wideband circularly polarized (CP) substrate integrated waveguide (SIW) end‐fire antenna constructed by a single‐layer substrate. Since wave‐rotation in planar SIW structure in end‐fire direction owns its natural difficulty, a novel method by incorporating two orthogonally polarized end‐fire elements is proposed and analyzed. An SIW antipodal tapered slot antenna is employed as the horizontally polarized element while an open‐ended SIW radiator loaded with printed transition is adopted as the vertically polarized one. Therefore, the combined two elements fed by an SIW narrow‐wall 90° directional coupler satisfies the necessary requirement for radiating CP wave in end‐fire direction. Parameter‐study is carried out to evaluate effects of the antenna parameters towards the CP performance. Finally, a prototype is fabricated and experimental results indicate that a 12% 3‐dB axial ratio bandwidth is obtained. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1111–1115, 2017
Novel design of microwave diplexers using gap waveguide technology
Authors: Farahani Hossein S. , Sadeghzadeh R.A. , Gharanfeli Naser , Kishk Ahmed A. 
Published: March 2017

ABSTRACTNovel design and implementation of microwave Diplexers utilizing groove gap waveguide resonators is presented. A high performance and cost effective Ku‐band Diplexer composed of fourth‐order TX and RX Chebyshev filters is designed, simulated, and fabricated. The simulation and measurement results show good agreement, which validate the design method. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1133–1136, 2017
A linear LTE‐advanced CMOS RF power amplifier with integrated phase linearizer
Authors: Jin Bo , Kim Younggwan , Woo Jung‐Lin , Park Sunghwan , Park Hongjong , Kwon Youngwoo 
Published: March 2017

ABSTRACTIn this work, a linear CMOS RF power amplifier (RF PA) to support 40‐MHz BW long‐term evolution‐advanced (LTE‐A) application is developed. The AM–PM distortion of the CMOS RF PA is compensated by the proposed wideband phase linearizer, which generates asymmetric triangular current waveform to provide pre‐distorted current to the RF PA. The fabricated PA is tested with 40‐MHz BW LTE‐A signal at 0.837 GHz carrier frequency and showing 30.3% overall system power‐added efficiency (PAE) and −36.1 dBc carrier aggregation (CA) evolved universal terrestrial radio access (E‐UTRA) adjacent channel leakage ratio (ACLR) at 24 dBm output power. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1119–1122, 2017
Neural modeling approach for trapping and thermal effects on AlGan/Gan HEMT
Authors: Elhamadi Taj‐Eddin , Boussouis Mohamed , Touhami Naima Amar , Lamsalli Mohammed 
Published: March 2017

ABSTRACTIn this article, a neural Approach is proposed for modeling the trapping and the thermal effect on AlGaN/GaN HEMT devices. The modeling approach is based on thermal DC and Pulsed I/V measurements. The proposed approach is tested for an
AlGaN/GaN HEMT. The simulation results are compared to DC and Pulsed I/V measurements. Good results are obtained for the DC and the dynamic I/V characteristics from different static bias points and over a large temperature interval
to
). © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1140–1142, 2017
Aperture‐coupling fed high isolation polarization diversity dual‐element MIMO antenna system for WLAN application
Authors: Li Haixiong , Zhang Gaigai , Xu Jiachen , Ding Jun , Guo Chenjiang 
Published: March 2017

ABSTRACTA novel compact aperture‐coupling fed, polarized diversity, high port isolation microstrip MIMO (multiple input and multiple output) antenna with two antenna elements is presented for WLAN application in this letter. The unique metal radiator is shared by the two antenna elements and the dimension of the proposed MIMO antenna is reduced by nearly a half. In addition, a square slot is etched in the shared radiator to shrink the antenna. The dual ports of the proposed antenna are arranged orthogonally to accept the polarized diversity gain and a corner cut, an extra strip in the metal radiator is also the effective structure to improve the ports isolation. The optimized port isolation (S12/S21) is reduced to −50.3 dB at the resonance frequency f0 = 5.74 GHz and the port isolation is lower than −27.3 dB at the desired band from 5.58 GHz to 5.88 GHz. The performance of proposed antenna is good enough for the application in MIMO wireless communication system. The proposed MIMO antenna has been fabricated for the experimental test and the measured results had a good agreement with the simulated. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1178–1182, 2017
Generation of Integration-Free Induced Pluripotent Stem Cells from Urine-Derived Cells Isolated from Individuals with Down Syndrome
Authors: M. Lee Young , Zampieri Bruna L. , Scott-McKean Jonah J. , Johnson Mark W. , Costa Alberto C.S. 
Published: March 2017

AbstractDown syndrome (DS) is a genetic disorder caused by trisomy 21 (T21). Over the past two decades, the use of mouse models has led to significant advances in the understanding of mechanisms underlying various phenotypic features and comorbidities secondary to T21 and even informed the design of clinical trials aimed at enhancing the cognitive abilities of persons with DS. In spite of its success, this approach has been plagued by all the typical limitations of rodent modeling of human disorders and diseases. Recently, several laboratories have succeeded in producing T21 human induced pluripotent stem cells (T21-iPSCs) from individuals with DS, which is emerging as a promising complementary tool for the study of DS. Here, we describe the method by which we generated 10 T21-iPSC lines from epithelial cells in urine samples, presumably from kidney epithelial origin, using nonintegrating episomal vectors. We also show that these iPSCs maintain chromosomal stability for well over 20 passages and are more sensitive to proteotoxic stress than euploid iPSCs. Furthermore, these iPSC lines can be differentiated into glutamatergic neurons and cardiomyocytes. By culturing urine-derived cells and maximizing the efficiency of episomal vector transfection, we have been able to generate iPSCs noninvasively and effectively from participants with DS in an ongoing clinical trial, and thus address most shortcomings of previously generated T21-iPSC lines. These techniques should extend the application of iPSCs in modeling DS and other neurodevelopmental and neurodegenerative disorders, and may lead to future human cell-based platforms for high-throughput drug screening.
An Easy Access to Bipyrazoles and Unusual Demethylation of Methyl Phosphorous Ester: Exploring the Synthetic Utility of Bestmann‐Ohira Reagent
Authors: Mahendran Vaithiyanathan , Pasumpon Kamaraj , Shanmugam Sivakumar 
Published: March 2017

AbstractAn efficient regioselective three‐component synthesis of bipyrazoles4 by reaction of α‐aroylidineketene dithioacetals 1, Bestmann‐Ohira reagent 2 a and hydrazine hydrate 3 using KOH as a base in methanol medium was reported. Salient features of the present methodology are theregioselective construction of two pyrazoles unit contains four different heteroatoms (nitrogen, oxygen, sulfur and phosphorous) under mild reaction conditions with excellent yield in a single operation. In addition, unusual demethylation of methyl phosphorous ester group was observed. Based on the control experiments, plausible reaction mechanism was proposed.
Mid-Miocene (post 12 Ma) Displacement along the Central Karakoram Fault Zone in the Nubra Valley, Ladakh, India from Spot LA-ICPMS U/Pb Zircon Ages of Granites
Authors: Brookfield Michael E. , Chung Sun-Lin , Shellnutt J. Gregory 
Published: March 2017

ABSTRACT
The Karakoram fault zone is a prominent right lateral fault that connects the frontal thrust of the North Pamir with the Indus suture zone near Mount Kailas. Its nature and age of initiation is controversial. In the Nubra valley, Ladakh, India, a Karakoram range granite is thrust over Cretaceous magmatic arc rocks and this thrust is cut by a western strand of the Karakoram fault zone. Three different lithologies from this granite gave weighted mean zircon U/Pb ages of 12.92±0.77 Ma, 12.41±0.43 Ma, and 11.72±0.31 Ma. The ages indicate a relatively short intrusive history of about 1 Ma for the phases: the geochemistry is practically identical to the Pangong leucogranites in the same tectonic block. The Karakoram fault zone in this area is thus less than ~12 Ma old which supports a post middle Miocene (Serravallian) age of Karakoram fault initiation in this area.
Beach Monazites from Alleppey: A Window to the Trivandrum Block, Southern India
Authors: Pruseth Kamal Lochan , Sahoo Debidarsani , Kumar Bijay , Kumar Vivek 
Published: March 2017

ABSTRACT
Detrital monazites can be used to reconstruct the tectonothermal history of their provenance. Dating of beach monazites from Alleppey by EPMA U-Th-Pbtotal technique using the centroid method demonstrates that the ages recorded by even a small number of 28 analyses from a single thin section grain mount can potentially reveal a considerable portion of the tectonothermal history of the Trivamdrum block. Three monazite populations were identified that yielded ages 605 ± 9, 575 ± 23 and 548 ± 11 Ma, which have their more or less exact counterparts reported from the Trivandrum Block. One monazite grain yielded random Paleoproterozoic ages ranging from 1756 Ma to 1345 Ma representing similar ages which earlier have been interpreted as due to differential Pb-loss from &gt;2000 Ma monazites during the late Neoproterozoic-Cambrian metamorphism.
Hydrochemical Characteristics of Groundwater Quality with Special Reference to Fluoride Concentration in Parts of Mulugu-Venkatapur Mandals, Warangal District, Telangana
Authors: Satyanarayana E. , Dhakate Ratnakar , Kumar D. Laxman , Ravindar P. , Muralidhar M. 
Published: March 2017

ABSTRACT
Hydrochemical studies were carried out in Mulugu-Venkatapur Mandals of Warangal district, Telangana state, India to find out the causes of high fluorides in groundwater and surface water causing a widespread incidence of fluorosis in local population. The fluoride concentration in groundwater ranges from 0.28 to 5.48 mg/l with a mean of 1.26 mg/l in pre-monsoon and 0.21 to 4.43 mg/l with a mean 1.45 mg/l in post-monsoon. About 32% and 34% of samples in pre and post-monsoon containing fluoride concentrations that exceed the permissible limit. The Modified Piper diagram reflects that, water belong to Ca+2-Mg+2-HCO3− to Na+-HCO3− facies. Negative chloroalkali indices in both the seasons prove that ion exchange took place between Na+ & K+ with Ca+2 and Mg+2 in aquatic solution in host rock. Different plots for major ions and molar ratios suggest that weathering of silicate rocks and water-rock interaction is responsible for major ion chemistry of water. High fluoride content in groundwater attributed to continuous water-rock interaction during the process of percolation with fluorite bearing country rocks under arid, low precipitation, and high evaporation conditions. The low calcium content in rocks and soils, and the presence of high content of sodium bicarbonate in soils and waters are important factors favouring high levels of fluoride in waters. The basement rocks provide abundant mineral sources of fluoride in the form of amphibole, biotite, fluorite, mica and apatite.