bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resistin: New serum marker for predicting severity of acute pancreatitis
Authors: Kibar Yunus İ , Albayrak Fatih , Arabul Mahmut , Dursun Hakan , Albayrak Yavuz , Ozturk Yasin 
Published: February 2016

Objective To assess the effectiveness of resistin in predicting the severity of acute pancreatitis. Methods Patients with acute pancreatitis who presented at the Gastroenterology Clinic, Erzurum Education and Research Hospital, Turkey were enrolled in this prospective study. White blood cell (WBC), C-reactive protein (CRP) and resistin levels were measured on admission and at 24 h, day 3 and day 7 following admission, along with other blood parameters. Patients were divided into two groups: mild acute pancreatitis and moderate/severe acute pancreatitis. Results Of 59 patients with acute pancreatitis (mild, n = 37; moderate/severe, n = 22), significant between-group differences were found in terms of resistin and CRP levels. Receiver operating curve analysis showed that resistin levels were better for predicting severe cases of acute pancreatitis than CRP or WBC levels on day 3 (area under the curve [AUC], 0.88 versus 0.81 and 0.63, respectively). Resistin levels on day 3 were better than CRP levels for predicting necrosis development (AUC, 0.70 versus 0.69, respectively). Conclusions Resistin may represent a new, effective indicator to predict the severity of acute pancreatitis and presence of necrosis in patients with acute pancreatitis.
Genetically lowered concentrations of circulating sRAGE might cause an increased risk of cancer: Meta-analysis using Mendelian randomization
Authors: Huang Qingxian , Mi Jia , Wang Xizhen , Liu Fang , Wang Dan , Yan Dong , Wang Bin , Zhang Shuping , Tian Geng 
Published: February 2016

Objectives To undertake a systematic meta-analysis of all variants in the gene encoding receptor for advanced glycation end products ( RAGE) to summarize their associations with cancer risk and changes in the levels of circulating soluble RAGE (sRAGE), with the aim of determining possible causality between circulating sRAGE and cancer risk. Methods Articles written in English were retrieved from MEDLINE® and EMBASE® databases. Two researchers independently identified eligible articles and extracted the data (analysed using STATA® software version 12.0). Results Fifteen articles qualified for inclusion in the meta-analysis of the RAGE–cancer association and three examined the RAGE–sRAGE relationship. The 82Ser/82Ser genotype was significantly associated with overall cancer risk compared with the 82Gly/Gly genotype (odds ratio 1.75, 95% confidence interval [CI] 1.46, 2.10). Carriers of the 82Ser/82Ser genotype had significantly reduced circulating sRAGE concentrations compared with the 82Gly/82Gly genotype. Mendelian randomization analysis demonstrated that a reduction of 100, 200 and 300 pg/ml in circulating sRAGE concentrations was associated with a 1.11-fold (95% CI 1.06, 1.25), 1.24-fold (95% CI 1.11, 1.57) and 1.38-fold (95% CI 1.18, 1.96) increased risk of developing cancer, respectively. Conclusions Genetically lowered concentrations of circulating sRAGE might cause an increased risk of cancer.
Clinical, pathological, immunohistochemical and molecular characterization of feline chronic gingivostomatitis
Authors: Rolim Veronica Machado , Pavarini Saulo Petinatti , Campos Fabrício Souza , Pignone Viviam , Faraco Cláudia , Muccillo Marcelo de Souza , Roehe Paulo Michel , da Costa Fernanda Viera Amorim , Driemeier David 
Published: February 2016

Objectives This study presents the clinical, pathological, immunohistochemical and molecular characterization of 26 cats with feline chronic gingivostomatitis (FCG). Methods Oral mucosal biopsies, blood and swabs were collected from cats presenting with oral lesions. The tissue sections were submitted for histopathology and immunohistochemical analysis for feline calicivirus (FCV), feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV). The swabs were subjected to PCR analysis for FCV, and blood for FeLV and FIV. Results The main clinical findings were dysphagia (88.2%), halitosis (76.5%), sialorrhea (47.1%), weight loss (41.2%), intense oral discomfort (35.3%), oral hemorrhage (17.6%), and lackluster and fragile coat (11.8%). Gross inspection revealed bilateral lesions across the palatoglossal fold to the lateral tongue base. The lesions were diffuse, proliferative, intensely red and friable, and bled easily upon examination in 80.8% of cases. In 23.1% of cases, the lesions were multifocal to coalescent, at times forming multiple vesicles on a reddened, edematous palatoglossal fold. Microscopic examination showed that 15.4% of lesions had moderate (grade 2) and 84.6% had severe (grade 3) inflammation. Immunohistochemistry revealed the presence of FeLV antigens in the epithelium and the inflammatory infiltrate of 30.8% of the cats with FCG. FCV antigens were not detected in the FCG lesions. Conclusions and relevance The FCG cases analyzed could not be correlated with FCV. It is possible that FeLV plays a role as a causal agent of lesions in cases where the presence of the virus has been confirmed by immunohistochemistry in epithelial samples.
Model-based roentgen stereophotogrammetric analysis of the surface replacement trapeziometacarpal total joint arthroplasty
Authors: ten Brinke B. , Mathijssen N. M. C. , Blom I. , Deijkers R. L. M. , Ooms E. M. , Kraan G. A. 
Published: February 2016

The primary aim of this clinical and radiostereometric study was to study the migration pattern of the surface replacement trapeziometacarpal joint prosthesis (SR™TMC, Avanta®, San Diego, CA). The secondary aims were to assess patient-related outcomes and prosthesis survival 5 years after surgery. Ten patients received the prosthesis. Radiostereometric radiographs were obtained 6 weeks, 6 months, 1 year and 5 years post-operatively and were analysed using model-based software. All patients completed DASH and Nelson Hospital scores at these follow-ups. Mean translations varied between 0.0 and 0.5 mm after 5 years. Rotation values could be calculated in six patients and mean rotations varied between −0.3 and 2.3°, although the precision of rotation values seems to be poor. The 5-year survival rate was 80%. Mean pre-operative DASH and Nelson Hospital scores were 53 (SD 14) and 51 (SD 13), respectively. Six months post-operatively, the DASH and Nelson Hospital scores had both significantly improved to 25 (SD 20) and 74 (SD 18) and remained high after 5 years. Implant stability was good 5 years post-operatively, and early migration did not predict implant failure in this study. Level of Evidence: IV.
Arthrodesis of the Subtalar Joint in a High School Football Player With a Talocalcaneal Coalition
Authors: Winslow John , Norland Ryan , Storb Nathan , Cannella Sam , King Deborah 
Published: February 2016

Tarsal coalition is a bony or fibrous bridge between 2 tarsal bones. The condition is typically congenital and presents in early to mid-adolescence. Common symptoms include ankle pain, stiffness, and limited range of motion. Conservative treatment of tarsal coalition consists of immobilization, short leg walking cast, steroid injections, physical therapy, ankle braces, and orthotics. When conservative care fails, surgical intervention for tarsal coalition includes excision of the coalition or joint arthrodesis. We present a case of a high school football player with a 5-year history of left ankle pain secondary to a talocalcaneal coalition. The athlete did not respond favorably to conservative treatment and underwent a subtalar joint arthrodesis. Prior to surgery, the athlete consented to self-reported functional outcome measures, range of motion measures, and 3D video gait analysis to evaluate the effects of surgery. Measurements were taken prior to surgery and 1½ years after surgery. Clinically significant improvements were seen in subjective outcome measures and functional ankle range of motion in this case. There is limited research available to validate long-term outcomes for current conservative and surgical treatments of tarsal coalition. In this case, joint arthrodesis resulted in a good long-term outcome for this athlete. Levels of Evidence: Therapeutic, Level IV: Case study
Technique Tip
Authors: Scott Daniel , Shi Glenn Guangyu , Adams Samuel 
Published: February 2016

Ankle fractures are among the most common traumatic injuries encountered by orthopaedic surgeons, but obtaining anatomic syndesmosis fixation can be difficult. Previous authors have described the centroidal axis of the syndesmosis. Our group has developed a novel technique of aligning the tibia and fibula along their anatomic centroidal axis using a targeting guide, which has showed good results in 1 patient at 1-year follow-up. Levels of Evidence: Level V: Expert opinion
Surgical management of an anomalous right coronary artery
Authors: Pontailler Margaux , Demondion Pierre , Lebreton Guillaume 
Published: February 2016

Abstract
Anomalous aortic origin of coronary arteries is a rare congenital heart disease that can be associated with sudden death. We present the case of a young patient who sustained a cardiac arrest revealing an anomalous origin of the right coronary artery. Unroofing and pericardial enlargement of the coronary artery ostia was performed and the patient is actually asymptomatic.
YouTubeTM as a source of patient information for ureteroscopy
Authors: Abboudi Hamid , Mikhail Michael , Ghazal-Aswad Mohammed , Michael Michael , Pope Alvan 
Published: February 2016

Objective: YouTubeTM has provided a platform that is utilised by millions. Patients are increasingly utilising this source of information. We set out to systematically analyse the quality of ureteroscopy videos. Materials and methods: YouTubeTM was searched using the term ‘ureteroscopy’. Content was assessed using the British Association of Urological Surgeons website criteria. Information relating to management options, procedural description, stent insertion, recovery and complications was rated. An overall rating was given. Videos were also analysed in terms of country of origin, view count, likes, dislikes, source and technical quality. The kappa statistic was used. Results: A total of 59 videos were analysed. The total number of viewings was 557,896 (range: 42– 121,943), with an average number of 9456 viewings per video. The information content was either poor or average in 98% ( n = 58) of videos, with only 2% ( n=1) rated as good and 0% achieving an excellent rating. Technical quality was rated as poor in 28 videos, average in 22 and good in nine videos. Most videos were broadcast by surgeons or surgical institutes (48/59). Conclusion: The quality of videos is variable. Patients should not be encouraged to use this for education. Opportunity has arisen for the endourology community to produce high quality video broadcasts to optimise patient understanding.
Patient Understanding of HIV and Hepatitis C Testing in an Emergency Department with an Integrated Program
Authors: Anderson Erik S. , Pfeil Sarah K. , Alter Harrison J. , White Douglas A. E. 
Published: February 2016

Introduction: We implemented triage nurse rapid HIV and hepatitis C virus (HCV) screening, in parallel with physician diagnostic testing, in our urban emergency department (ED). Methods: A 2-month cross-sectional survey was performed to determine the proportion of patients who correctly reported being tested for HIV and HCV. Results: A total of 492 patients were surveyed. Fifty-one (70%) of the 73 patients who reported being HIV tested and 372 (89%) of the 419 patients who reported not being HIV tested were correct. Thirty (60%) of the 50 patients who reported being HCV tested and 416 (94%) of the 442 patients who reported not being HCV tested were correct. Conclusion: Although most ED patients correctly reported whether testing was performed, there were many who did not. Although ED screening programs for HIV and HCV serve as an important venue for screening, strategies to improve communication require attention.
Adaptation Strategies of Individuals With Anterior Cruciate Ligament Reconstruction
Authors: Roper Jaimie A. , Terza Matthew J. , Tillman Mark D. , Hass Chris J. 
Published: February 2016

Background: Despite the strong implications for rehabilitation design, the capability of individuals with anterior cruciate ligament reconstruction (ACLR) to adapt and store novel gait patterns have not been well studied. Purpose: To investigate how reconstructive surgery may affect the ability to adapt and store novel gait patterns in persons with ACLR while walking on a split-belt treadmill. Study Design: Controlled laboratory study. Methods: Gait adaptation was compared between 20 participants with ACLR and 20 healthy controls during split-belt treadmill walking. Gait adaptation was assessed in slow- and fast-adapting parameters by (1) the magnitude of symmetry during late adaptation and (2) the amount of the asymmetry during de-adaptation. Results: Healthy individuals adapted a new walking pattern and stored the new walking pattern equally in both the dominant and nondominant limbs. Conversely, individuals with ACLR displayed impairments in both slow-adapting and fast-adapting derived gait adaptation and significant differences in behavior between the reconstructed and uninjured limb. Conclusion: While surgical reconstruction and physical therapy are aimed at improving mechanical stability to the knee, the study data suggest that fundamental features of motor control remain altered. After ACLR, participants display an altered ability to learn and store functional gait patterns.
The system Ag–Pd–Te: phase relations and mineral assemblages
Authors: Vymazalová Anna , Laufek František , Kristavchuk Alexandr V. , Chareev Dmitriy A. , Drábek Milan 
Published: February 2016

AbstractThe phase equilibria in the system Ag–Pd–Te were studied by the technique of using an evacuated silica glass tube at 350° and 450°C. Five ternary phases were synthesized: sopcheite (Pd3Ag4Te4), lukkulaisvaaraite (Pd14Ag2Te9),telargpalite (Pd2–xAg1+xTe) and the previously unknown phases Pd7.5–xAg0.5+xTe3and Pd2+xAg2–xTe.The synthetic telargpalite has a compositional range from 26 to 29 wt.% Ag, with the formula Pd2–xAg1+xTe, where x varies from 0.09 to 0.22. The phase Pd2+xAg2–xTe has a compositional range from 34 to 35 wt.% Ag, where x varies from 0.18 to 0.24. The phase Pd7.5–xAg0.5+xTe3forms a solid solution from 4 to 11 wt.% Ag, wherexvaries from 0.02 to 0.83. Phases Pd20Te7and Pd13Te3dissolve up to 3.5 and 2 wt.% Ag, respectively. Other binary palladium tellurides do not dissolve Ag. The phase Pd3Ag4Te4, an analogue of the mineral sopcheite, forms a stable association with hessite and kotulskite it also coexists with lukkulaisvaaraite. Sopcheite is stable up to 383°C. Natural occurrences of hessite, kotulskite and lukkulaisvaaraite together in equilibrium indicate formation above this temperature. Phase relations defined the mineral assemblages that can be expected to occur in nature.The phase Pd7.5–xAg0.5+xTe3potentially represents a new mineral; it will probably be found in association with lukkulaisvaaraite and telargpalite or telluropalladinite, among other platinum-group minerals. The phasePd2+xAg2–xTe can be found in association with telargpalite. Mineral assemblages defined in this study can be expected in Cu-Ni-PGE mineral deposits, associated with mafic and ultramafic igneous rocks, particularly in mineralized zones with known silver-palladium tellurides.
Alzheimer’s Disease Assessment Scale–Cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies
Authors: Podhorna Jana , Krahnke Tillmann , Shear Michael , E Harrison John ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: February 2016

Abstract
Background
Development of new treatments for Alzheimer’s disease (AD) has broadened into early interventions in individuals with modest cognitive impairment and a slow decline. The 11-item version of the Alzheimer’s Disease Assessment Scale–Cognitive subscale (ADAS-Cog) was originally developed to measure cognition in patients with mild to moderate AD. Attempts to improve its properties for early AD by removing items prone to ceiling and/or by adding cognitive measures known to be impaired early have yielded a number of ADAS-Cog variants. Using Alzheimer’s Disease Neuroimaging Initiative data, we compared the performance of the 3-, 5-, 11- and 13-item ADAS-Cog variants in subjects with early AD. Given the interest in enrichment strategies, we also examined this aspect with a focus on cerebrospinal fluid (CSF) markers.

Methods
Subjects with mild cognitive impairment (MCI) and mild AD with available ADAS-Cog 13 and CSF data were analysed. The decline over time was defined by change from baseline. Direct cross-comparison of the ADAS-Cog variants was performed using the signal-to-noise ratio (SNR), with higher values reflecting increased sensitivity to detect change over time.

Results
The decline over time on any of the ADAS-Cog variants was minimal in subjects with MCI. Approximately half of subjects with MCI fulfilled enrichment criteria for positive AD pathology. The impact of enrichment was detectable but subtle in MCI. The annual decline in mild AD was more pronounced but still modest. More than 90 % of subjects with mild AD had positive AD pathology. SNRs were low in MCI but greater in mild AD. The numerically largest SNRs were seen for the ADAS-Cog 5 in MCI and for both the 5- and 13-item ADAS-Cog variants in mild AD, although associated confidence intervals were large.

Conclusions
The possible value of ADAS-Cog expansion or reduction is less than compelling, particularly in MCI. In mild AD, adding items known to be impaired at early stages seems to provide more benefit than removing items on which subjects score close to ceiling.
Mini Mental State Examination and Logical Memory scores for entry into Alzheimer’s disease trials
Authors: Chapman Kimberly R. , Bing-Canar Hanaan , Alosco Michael L. , Steinberg Eric G. , Martin Brett , Chaisson Christine , Kowall Neil , Tripodis Yorghos , Stern Robert A. 
Published: February 2016

Abstract
Background
Specific cutoff scores on the Mini Mental State Examination (MMSE) and the Logical Memory (LM) test are used to determine inclusion in Alzheimer’s disease (AD) clinical trials and diagnostic studies. These screening measures have known psychometric limitations, but no study has examined the diagnostic accuracy of the cutoff scores used to determine entry into AD clinical trials and diagnostic studies.

Methods
ClinicalTrials.gov entries were reviewed for phases II and III active and recruiting AD studies using the MMSE and LM for inclusion. The diagnostic accuracy of MMSE and LM-II cutoffs used in AD trials and diagnostic studies was examined using 23,438 subjects with normal cognition, mild cognitive impairment (MCI), and AD dementia derived from the National Alzheimer’s Coordinating Center database.

Results
MMSE and LM cutoffs used in current AD clinical trials and diagnostic studies had limited diagnostic accuracy, particularly for distinguishing between normal cognition and MCI, and MCI from AD dementia. The MMSE poorly discriminated dementia stage.

Conclusions
The MMSE and LM may result in inappropriate subject enrollment in large-scale, multicenter studies designed to develop therapeutics and diagnostic methods for AD.
Genome sequence of Shinella sp. strain DD12, isolated from homogenized guts of starved Daphnia magna
Authors: Poehlein Anja , Freese Heike , Daniel Rolf , Simeonova Diliana D. 
Published: February 2016

AbstractShinella sp. strain DD12, a novel phosphite assimilating bacterium, has been isolated from homogenized guts of 4 days starved zooplankton Daphnia magna. Here we report the draft genome of this bacterium, which comprises 7,677,812 bp and 7505 predicted protein-coding genes.
Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease
Authors: Smith R E , Reyes N J , Khandelwal P , Schlereth S L , Lee H S , Masli S , Saban D R 
Published: February 2016

Abstract
Allergic eye disease, as in most forms of atopy, ranges in severity among individuals from immediate hypersensitivity to a severe and debilitating chronic disease. Dendritic cells play a key role in stimulating pathogenic T cells in allergen re-exposure, or secondary responses. However, molecular cues by dendritic cells underpinning allergic T cell response levels and the impact that this control has on consequent severity of allergic disease are poorly understood. Here, we show that a deficiency in thrombospondin-1, a matricellular protein known to affect immune function, has subsequent effects on downstream T cell responses during allergy, as revealed in an established mouse model of allergic eye disease. More specifically, we demonstrate that a thrombospondin-1 deficiency specific to dendritic cells leads to heightened secondary T cell responses and consequent clinical disease. Interestingly, whereas thrombospondin-1-deficient dendritic cells augmented activity of allergen-primed T cells, this increase was not recapitulated with naïve T cells in vitro. The role of dendritic cell-derived thrombospondin-1 in regulating secondary allergic T cell responses was confirmed in vivo, as local transfer of thrombospondin-1-sufficient dendritic cells to the ocular mucosa of thrombospondin-1 null hosts prevented the development of augmented secondary T cell responses and heightened allergic eye disease clinical responses. Finally, we demonstrate that topical instillation of thrombospondin-1-derived peptide reduces T cell activity and clinical progression of allergic eye disease. Taken together, this study reveals an important modulatory role of dendritic cell-derived thrombospondin-1 on secondary allergic T cell responses and suggests the possible dysregulation of dendritic cell-derived thrombospondin-1 expression as a factor in allergic eye disease severity.
Adipocyte Versus Somatotrope Leptin: Regulation of Metabolic Functions in the Mouse
Authors: Odle Angela Katherine , Allensworth-James Melody , Haney Anessa , Akhter Noor , Syed Mohsin , Childs Gwen V. 
Published: February 2016

AbstractLeptin regulates food intake and energy expenditure (EE) and is produced in adipocytes, the pituitary, and several other tissues. Animals that are leptin or leptin receptor deficient have major metabolic complications, including obesity. This study tests the hypothesis that the pituitary somatotrope may contribute a source of leptin that maintains some of these metabolic functions. We created 2 different tissue-specific leptin knockout animals: a Somatotrope-Lep-null model and an Adipocyte-Lep-null model. Metabolic analysis of both models, along with a global deletion model, was performed. The Somatotrope-Lep-null animals had fewer somatotropes, and females had a 76% decrease in serum prolactin. During the dark (feeding) phase, females had a 35% increase in ambulation coupled with a 4% increase in EE. Mutants showed no change in food intake or weight gain and EE was unchanged in males. During the light (sleep) phase, Somatotrope-Lep-null mutant males had lower EE and females continued to have higher EE. The respiratory quotients (RQs) of mutants and littermate controls were decreased in males and increased in females; all were within the range that indicates predominant carbohydrate burning. The massively obese Adipocyte-Lep-null animals, however, had significant increases in food intake, sleep, and increased EE, with decreased activity. Changes in RQ were sexually dimorphic, with female mutants having higher RQ and males having decreased RQ. We conclude that both adipocyte and somatotrope leptin contribute to the metabolic homeostasis of the mouse, and that extraadipocyte sources of leptin cannot overcome the major metabolic challenges seen in these animals.