bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Lymph Node Count and Overall Survival in Node-Negative Endometrial Cancers
Authors: Seagle Brandon-Luke L. , Gilchrist-Scott Douglas , Graves Stephen , Strohl Anna E. , Nieves-Neira Wilberto , Shahabi Shohreh 
Published: August 2017

Purpose To estimate whether the number of lymph nodes removed during surgery is associated with overall survival among women with endometrial cancer. Methods We performed a retrospective cohort study of women with node-negative, stage I to IIIB endometrial cancer (n = 152,702) identified from the 1998-2011 National Cancer Database. Multivariable Cox proportional hazards regression tested for an association of lymph node count with survival. Restricted mean survival and relative hazard curves were plotted for survival as a function of number of removed lymph nodes. Results Among women with node-negative endometrioid endometrial cancer, for each additional five lymph nodes removed, the hazard for death decreased: stage I, the hazard ratio (HR) was 0.95 (95% CI, 0.93 to 0.97; P < .001), stage II, HR was 0.90 (95% CI, 0.87 to 0.94; P < .001); and stage IIIA-B, HR was 0.92 (95% CI, 0.88 to 0.96; P < .001). When grouped by grade, each additional five lymph nodes removed was also associated with decreased hazard for death: grade 1, HR was 0.96 (95% CI, 0.93 to 0.99; P = .009); grade 2, HR was 0.91 (95% CI, 0.89 to 0.94; P < .001); and grade 3, HR was 0.95 (95% CI, 0.92 to 0.97; P < .001). Increased lymph node dissection was also associated with increased survival among women with node-negative stage II (HR, 0.92; 95% CI, 0.86 to 0.98; P = .01) or stage IIIA-B (HR, 0.94; 95% CI, 0.89 to 0.99; P = .025) uterine serous carcinoma, but not among women with carcinosarcoma or clear cell adenocarcinoma. Five-year survival for women with one to four nodes removed and endometrioid or serous histology was 85% (95% CI, 84% to 85%) and 54% (95% CI, 50% to 59%), respectively. Five-year survival was significantly higher for women with ≥ 20 removed nodes and endometrioid (91%; 95% CI, 90% to 91%) or serous (72%; 95% CI, 68% to 76%) histology ( P < .001). Conclusion Increased lymph node count is associated with a 1% to 14% decreased hazard of death per each additional five lymph nodes removed and a 5% to 20% increased 5-year survival among women with pathologically node-negative endometrioid and serous endometrial cancers.
Differential recruitment of E3 ubiquitin ligase complexes regulates RET isoform internalization
Authors: Hyndman Brandy D. , Crupi Mathieu J. F. , Peng Susan , Bone Leslie N. , Rekab Aisha N. , Lian Eric Y. , Wagner Simona M. , Antonescu Costin N. , Mulligan Lois M. 
Published: August 2017

ABSTRACT
The RET receptor tyrosine kinase is implicated in normal development and cancer. RET is expressed as two isoforms, RET9 and RET51, with unique C-terminal tail sequences that recruit distinct protein complexes to mediate signals. Upon activation, RET isoforms are internalized with distinct kinetics, suggesting differences in regulation. Here, we demonstrate that RET9 and RET51 differ in their abilities to recruit E3 ubiquitin ligases to their unique C-termini. RET51, but not RET9, interacts with, and is ubiquitylated by CBL, which is recruited through interactions with the GRB2 adaptor protein. RET51 internalization was not affected by CBL knockout but was delayed in GRB2-depleted cells. In contrast, RET9 ubiquitylation requires phosphorylation-dependent changes in accessibility of key RET9 C-terminal binding motifs that facilitate interactions with multiple adaptor proteins, including GRB10 and SHANK2, to recruit the NEDD4 ubiquitin ligase. We showed that NEDD4-mediated ubiquitylation is required for RET9 localization to clathrin-coated pits and subsequent internalization. Our data establish differences in the mechanisms of RET9 and RET51 ubiquitylation and internalization that may influence the strength and duration of RET isoform signals and cellular outputs.
This article has an associated First Person interview with the first authors of the paper.
Diagnosis of three different pathogenic microorganisms by gas chromatography-mass spectrometry
Authors: Karami Najmeh , Mirzajani Fateme , Rezadoost Hassan , Karimi Abdollah , Fallah Fatemeh , Ghassempour Alireza , Aliahmadi Atusa 
Published: August 2017

Background: Diagnoses of respiratory tract infections usually happen in the late phase of the disease and usually result in reduction of the pathogen load after broad-spectrum antibiotic therapy, but not in eradication of the pathogen. The development of a non-invasive, fast, and accurate method to detect pathogens has always been of interest to researchers and clinicians alike. Previous studies have shown that bacteria produce organic gases. The current study aimed to identify the volatile organic compounds (VOCs) produced by three respiratory tract pathogens, including Staphylococcus aureus, Escherichia coli and Candida albicans. Methods: The volatile organic compounds (VOCs) produced were identified by gas chromatography–mass spectrometry(GC-MS), with prior collection of microbial volatile compounds using solid phase microextraction (SPME) fiber. The volatile compounds were collected by obtaining bacterial headspace samples. Results: Results showed that these three organisms have various VOCs, which were analyzed under different conditions. By ignoring common VOCs, some species-specific VOCs could be detected. The most important VOC of E. coli was Indole, also some important VOCs produced by S. aureus were 2,3-Pentandione, cis-Dihydro-α-terpinyl acetate, 1-Decyne, 1,3-Heptadiene-3-yne, 2,5-dimethyl Pyrazine, Ethyl butanoate and Cyclohexene,4-ethenyl furthermore, most of identified compounds by C. albicans are alcohols. Conclusions: The detection of VOCs produced by infectious agents maybe the key to make a rapid and precise diagnosis of infection, but more comprehensive studies must be conducted in this regard.
People who report anomalous information reception have higher dissociation symptom scores
Authors: Wahbeh Helané , Radin Dean 
Published: August 2017

Background: Dissociative states exist on a continuum from nonpathological expressions, such as highway hypnosis and day-dreaming, to pathological states of derealization and depersonalization. Claims of anomalous information reception (AIR) are often dismissed as symptoms of dissociation disorder, despite other studies that show otherwise. This study examined the relationship of dissociation symptoms and AIR in a large convenience sample (n= 3,984). Methods: These secondary analyses of cross-sectional survey data were examined. The survey included demographics, the Dissociation Experience Scale Taxon, and AIR data. Summary statistics and linear and logistic regressions evaluated dissociation variables and AIR endorsement relationships with and without covariates. Results: 3023 respondents with complete data were included. Participants were mostly middle aged (51 years ± 16; range 17-96), female (70%), Caucasian (85%), college educated (88%), had an annual income over $50,000 (55%), were raised Christian (71%), and now affiliated as Spiritual but not Religious (60%). AIR ability was endorsed by 42% of participants, with their first experience starting in childhood (81%), and 53% having family members with similar experiences. The mean dissociation score was 14.4 ± 17.3 (range 0-100) for all participants and was significantly higher for AIR claimants (18.2 ± 19.3), as compared to non-claimants (11.8 ± 15.2; t = -10.3, p<0.000). In total, 11% of AIR non-endorsers and 22% of AIR endorsers had a cut-off score greater than 30 (X2 = 63.0, p=<0.000). Conclusions: Both AIR claimants and non-claimants scored lower than the clinical cutoff for dissociation, with the claimants having significantly higher scores. Future studies comparing AIR claimants versus non-claimants may benefit by incorporating comprehensive dissociation symptom measurement, as well as their effects on the person’s functionality, to discern the pathological versus non-pathological nature of purported AIR experiences.
Fast Approximation Methods for Online Scheduling of Outpatient Procedure Centers
Authors: Berg Bjorn P. , Denton Brian T. 
Published: August 2017

This paper presents a new model for online decision making. Motivated by the healthcare delivery application of dynamically allocating patients to procedure rooms in outpatient procedure centers, the online stochastic extensible bin-packing problem is described. The objective is to minimize the combined costs of opening procedure rooms and utilizing overtime to complete a day’s procedures. The dynamic patient-allocation decisions are made in an uncertain environment where the number of patients scheduled and the procedure durations are not known in advance. The resulting optimization model’s tractability focuses the paper’s attention on approximation methods and a special case that is amenable to decomposition-based solution methods. Theoretical performance guarantees are presented for list-based approximation methods as well as an approximation that is common in practice, where procedure rooms are reserved for patient groups in advance. Numerical results based on a real outpatient procedure center demonstrate the favorable results of the list-based approximations based on their average and worst case performances, as well as their computational requirements. Further, the numerical experiments show that the policy of reserving procedure rooms for patient groups in advance can perform poorly. These results are contrary to common practice and favor alternative, and still easy-to-implement, policies. The online supplement is available at https://doi.org/10.1287/ijoc.2017.0750 .
Managing Reliability and Stability Risks in Forest Harvesting
Authors: Lejeune Miguel A. , Kettunen Janne 
Published: August 2017

The timing of forest stands harvesting is an important operational decision in forestry. Major goals of private nonindustrial forest owners are to achieve a steady flow of profits while reaching an overall satisfactory and reliable profit level. These goals are pursued under uncertainties in the growth of trees in different regions and in the prices of wood products. We propose an optimization framework that uses financial risk concepts to capture the above goals and uncertainties, and apply it to a real forestry problem in Finland. Our results demonstrate that the obtained harvesting schedules outperform those obtained without the explicit consideration of the stability and reliability requirements in harvest profits. More generally, our results indicate that the forest owner can improve the profit stability by (i) harvesting a greater number of forest stands early and (ii) harvesting in the first periods of the planning horizon stands that are predominantly composed of slow-growing forests. This research responds to the call for scenario-based approaches that represent well, and in a solvable way, multiple uncertainties in large forestry problems. This study fills in a gap in stochastic programming and can be a cornerstone for subsequent improvements in the solution of combinatorial chance-constrained problems with multirow random technology matrix.The online appendix is available at https://doi.org/10.1287/msom.2017.0626 .
Point-of-care fluorescence imaging predicts the presence of pathogenic bacteria in wounds: a clinical study
Authors: Rennie M.Y. , Lindvere-Teene L. , Tapang K. , Linden R. 
Published: August 2017

Objective: Bacteria in chronic wounds are invisible to the naked eye and can lead to delayed wound healing. Point-of-care bacterial fluorescence imaging illuminates a wound with 405nm light, triggering bacteria to produce red fluorescence and enabling real-time bacterial localisation. Prospective, single-blind clinical trials (clinicaltrials.gov #NCT02682069, #NCT03091361) were conducted to determine the positive predictive value (PPV) of this red fluorescence for detecting bacteria in chronic wounds. Method: Lower limb chronic wounds were imaged for bacterial fluorescence using the MolecuLight i:X imaging device. Regions positive for red fluorescence were discretely sampled using either biopsy or curettage to correlate red fluorescence signals to bacterial presence and analysed via gold standard quantitative polymerase chain reaction (qPCR) or via semi-quantitative culture analysis respectively. Results: A total of 60 lower limb chronic wounds were imaged. Quantitative PCR analysis of wound tissue biopsies obtained from regions of red fluorescence yielded a PPV of 100%. Total bacterial load in these areas was ≥104 CFU/g. Semi-quantitative culture analysis of curettage scrapings from regions of red fluorescence yielded a PPV of 100%, with predominately moderate or heavy bacterial growth. There were nine distinct bacterial species detected, all common pathogens in chronic wounds. Staphylococcus aureus was the most prevalent species. Conclusion: Bacterial fluorescence image-guided curettage or biopsy sampling positively predicts bacterial presence in wounds at potentially harmful levels, entirely eliminating the risk of false negative sampling. Fluorescence imaging of wounds offers clinicians real-time information on a wound's bacterial burden, insight which can influence treatment decisions at the point-of care.
Effective wound bed preparation using maggot debridement therapy for patients with critical limb ischaemia
Authors: Nishijima A. , Gosho M. , Yoshida R. , Yanagibayashi S. , Takikawa M. , Nishijima J. , Sekido M. , Yamamoto N. 
Published: August 2017

Objective: Patients with critical limb ischaemia (CLI) lack sufficient blood flow in to the limb, which leads to difficulties in the normal wound healing process. Therefore, maggot debridement therapy (MDT) has not generally been recommended for CLI patients. We evaluated the effectiveness of wound bed preparation by MDT in CLI patients who had undergone mid-foot amputation. Methods: Patients who underwent mid-foot amputation after angioplasty between April 2014 and October 2016 were retrospectively investigated by classifying them into an MDT group or a conventional treatment group. The primary outcome was defined as achievement of wound healing. Secondary outcomes were the proportions of amputation-free survival (AFS) and successful ambulatory improvement. Propensity scores were used to evaluate treatment outcomes based on five factors: ankle-brachial index, skin perfusion pressure of the foot, nutritional status, experience with dialysis and age. Results: A total of 39 patients (39 legs) were included, seven within the MDT group and 32 in the conventional treatment group. Clinical backgrounds of the two groups showed no significant differences except for higher albumin levels for the MDT group (3.5±0.4g/dl; p=0.014). The wound healing proportion was significantly higher in the MDT group (86%) than in the control group (38%) (p=0.035). At 6 months after amputation, no significant differences were found between the two groups for AFS (71% versus 47%; p=0.41) or ambulatory capability (43% versus 28%; p=0.65). This result was also similar to the propensity score adjustment analysis. Conclusions: The efficacy of MDT with favourable wound bed preparation was shown in our CLI patients based on effective debridement and granulation formation by maggots, avoiding the loss of their heels. Wound-healing rates after MDT were higher for patients than for those receiving conventional treatment. MDT is considered a valid adjuvant treatment strategy for patients with CLI after revascularisation treatment is conducted. More favourable wound bed preparation and successful graft take were achieved in the MDT group, suggesting the effectiveness of MDT for wound healing in CLI patients.
PROPUESTA INICIAL PARA EL DESARROLLO DE UNA METODOLOGÍA PARA LA IMPLEMENTACIÓN DE IPTv6 SOBRE IMS
Authors: Granados Cárdenas Jean Paul , López Sarmiento Danilo Alfonso , Hernández Suárez César Augusto 
Published: August 2017

La televisión digital ha evolucionado continuamente desde su presentación digital terrestre (DVB-T), pasando por el estándar satelital (DVB-S) hasta llegar a su presentación actual conocida como IPTV (Internet Protocolo Television) que ofrece múltiples servicios multimedia tales como voz, video y datos, transportados con ciertos niveles de calidad de servicio, seguridad, interactividad y confianza gracias a la utilización de la pila de protocolos TCP/IP. En tal sentido el artículo pone a disposición de la comunidad académica una propuesta metodológica inicial que pretende servir de guía en la implementación de este tipo de sistemas sobre una plataforma de libre distribución conocida como IMS (IP Multimedia Subsystem) para redes de área local tipo IPv6.
Nazwy w dyskursie – w kontekście koncepcji wtórnej oralności
Authors: Rutkowski Mariusz 
Published: August 2017

In the paper, the chosen cases of using the proper names revealing the residual orality in the term of Walter Ong are presented. What is characteristic, proper names are used in the extensive, aggregative formulas, in their full-forms rather than in potential abbreviated forms (e.g. name of Polish political party Prawo i Sprawiedliwość instead its abbreviation PiS). Another feature is formulas with the stable collocations, used for strengthen the persuasive value of the utterances. Another residual orality features are: agonistically toned and homeostatic – proper names in those utterances may assist in the political rhetoric, or ever strengthen the creation of the new political myths.
Effects of cotton stalk, maize stalk and almond bark on some soil microbial activities
Authors: Küçük Çiğdem , Tekgül Y.Tuba 
Published: August 2017

AbstractWith the increase of agricultural production, residues of crop are the main source of organic matter in the soil and they are alternatives to inorganic fertilizers. For this purpose, effects of organic residues (cotton stalk, maize stalk, almond bark) commonly grown in Turkey were investigated for some soil microbial activity in clay soil. In this study, incubation experiment was set up. Five doses (0%, 2%, 4%, 6% and 8%) of organic residues (maize stalks, cotton stalks or almond bark) were applied to soil. Soil microbiological properties of soil samples such as CO2respiration, dehydrogenase and urease activity were determined. According to the results obtained, maize stalk, cotton stalks and almond bark applications increased some soil microbiological activities, such as CO2respiration, dehydrogenase and urease activities according to control soil. Maize stalk in comparison to other residues affects better on the biological properties of the soil. It is determined that enhancing effects of the added organic residues (maize stalk, cotton stalk, almond bark) into the soil were changed according to the type of organic residues, dosage and application terms.
Zur thermischen Modellierung inkompressibler Rohrströmungen
Authors: Bachler Simon , Huber Johannes , Woittennek Frank 
Published: August 2017

Zusammenfassung
Im Beitrag wird das thermische Verhalten von durchströmten Rohren
untersucht. Dazu werden detaillierte physikalische Modelle unterschiedlicher
Komplexität hergeleitet, wobei die Wärmespeicherfähigkeit der Rohrwand
jeweils explizit berücksichtigt wird. Für die vorgeschlagenen
verteilt-parametrischen Modelle werden geschlossene Lösungen angegeben.
Ausgehend von diesen Lösungen wird ein neues
Totzeit-Differentialgleichungs-Modell vorgestellt, das als Grundlage für
Simulationen und Reglerentwürfe dienen kann. Dieses wird in
Simulationsstudien und anhand von Messdaten mit einem, vor
allem in regelungstechnischen Anwendungen populären, sehr einfachen
Totzeit-Differentialgleichungs-Modell verglichen.
Nephropathology: A Cornerstone for Understanding and Estimation of Recent Advances in Glomerular Diseases
Authors: Capusa Cristina , Mehedinti Ana-Maria , Leh Sabine , Marti Hans-Peter 
Published: August 2017

Abstract
The developments in the field of kidney pathology are major objectives for nephrology worldwide, since the histopathologic diagnosis is a cornerstone for all glomerulopathies (either primary or secondary related to systemic diseases-for tubulointerstitial and vascular lesions as well as renal allograft nephropathy). Moreover, the correct interpretation of kidney tissue samples is a challenge for pathologists too. Consequently, a new subspecialty - nephropathology, was accepted by many medical schools in various universities, while dedicated scientific meetings, journals and websites were also created. In the following few pages, a short overview on the history, classic and novel meanings of the renal pathology for the understanding of glomerular pathophysiology will be discussed.
Water Footprint of main crops in Austria / Wasser-Fußabdruck wichtiger Nutzpflanzen in Österreich
Authors: Thaler Sabina , Gobin Anne , Eitzinger Josef 
Published: August 2017

Summary
Water is a key resource for human activities and a critical trigger for the welfare of the whole society. The agricultural sector makes up the main share in global freshwater consumption and is therefore responsible for a large part of the water scarcity in many drought prone regions. As an indicator that relates human consumption to global water resources, the “Water Footprint” (WF) concept can be used, where in case of crop production the total consumed water of crop fields for the crop growing seasons is related to the harvested dry matter crop yield (such as grains). In our study, we simulated the green and primary blue WF of selected main crops for Austrian conditions. Different irrigation scheduling scenarios, demonstrated for a main agricultural production area and various crops in Austria with significant irrigation acreage, were studied. The impact of climate and soil conditions on the green crop WFs of reference crops over the whole territory of Austria were simulated in a second step. Sunflower, winter wheat and grain maize showed the highest WF in the semi-arid study regions, especially on soils with low water capacity. In more humid regions, low temperatures were the main limiting factor on the crop yield potential and frequently led to higher WFs due to lower yields.
A new micro-baking method for determination of crumb firmness properties in fresh bread and bread made from frozen dough / Entwicklung eines Mikrobackversuches zur Evaluierung der Krumeneigenschaften von frischen Broten und Broten aus vorgegarten Tiefkühlteiglingen
Authors: Frauenlob Johannes , Nava Marta , D’Amico Stefano , Grausgruber Heinrich , Lucisano Mara , Schoenlechner Regine 
Published: August 2017

Summary
In general, micro-baking tests are used to determine the baking quality when only low amounts of test flour are available, for example, in grain breeding. Several micro-methods are described in literature, but none of them allows the determination of bread crumb texture parameters. Therefore, a micro-baking procedure that offers this option was developed, and it was also evaluated for bread made from pre-fermented frozen doughs. In this procedure, Rapid Visco Analyser (RVA) sample cans were used as baking pans. To examine the capability of this procedure, three wheat flours with different starch properties were chosen. The obtained breads were analyzed with respect to specific loaf volume, crust color and bread crumb firmness. Additionally, a storage test (0-5 days) was performed to determine the crumb firming parameters by kinetics of the Avrami equation. The obtained specific bread volumes revealed significant differences between the flours and the coefficients of variation ranged between 4.2 and 5.5%. Crumb firmness measurement was able to identify significant differences within the samples. The obtained data on firming kinetics reflected the expected properties of samples with different starch properties. Overall, this work demonstrated the feasibility of crumb property measurement on breads on a micro-scale.