bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary and Nondietary Triggers of Oral Ulcer Recurrences in Behçet's Disease
Authors: Volle Geoffroy , Fraison Jean‐Baptiste , Gobert Delphine , Goulenok Tiphaine , Dhote Robin , Fain Olivier , Gonzalez‐Chiappe Solange , Lhote François , Papo Thomas , Thuillier Aurélie , Rivière Sophie , Mahr Alfred 
Published: November 2016

ObjectiveThe nature and impact of food and other external triggers in recurrences of Behçet's disease (BD)‐related oral ulcers (OUs) remain unknown. This survey investigated dietary and nondietary triggers of BD‐related OU recurrences.MethodsPatients with BD who were followed in 7 French hospital departments completed a self‐administered patient questionnaire. General and specific dietary triggering factors were sought in open questions. The questionnaire also included closed questions, notably to evaluate the effect of 6 general triggering situations and 24 selected foods. The results were expressed as number (percentage) of positive responses.ResultsAmong the 101 questionnaires distributed, 81 were usable. Among the 81 patients, 96% fulfilled the International Criteria for Behçet's Disease classification criteria, and 53% qualified their OU recurrences during the previous 12 months as very discomforting or discomforting. For the 6 general situations suggested, 50 patients (62%) declared ≥1 as a “sure” trigger of OU recurrences. In both open and closed questions, the most frequent triggers were fatigue/stress (37–47% of patients) and food (32–35%). Among the 24 suggested foods, nuts (48%), pineapple (42%), peanuts (32%), Emmental cheese (30%), almonds (23%), lemons (22%), and other cheeses (21%) were the most frequently reported. The corresponding open question gave consistent findings but with lower frequencies.ConclusionMost patients can identify triggers of recurring BD‐related OUs, with fatigue/stress and food representing the most frequent triggers. The management of OU must consider such external factors. The histamine‐rich or ‐liberating properties of the commonly cited OU‐triggering foods suggest a hyperreactivity mechanism.
Fabrication and in vitro evaluation of novel pH‐sensitive poly (2‐methoxyethyl methacrylate‐co‐itaconic acid) microgels
Authors: Rashid Zermina , Ranjha Nazar M. , Razzaq Rabia , Raza Hina 
Published: November 2016

AbstractThe present work focused on the synthesis and evaluation of cross‐linked poly(2‐methoxyethyl methacrylate‐co‐itaconic acid) [p(MEMA‐co‐IA)] microgels for controlled and extended drug delivery, in an attempt to improve the bioavailability of the drugs and to get maximum therapeutic benefits. A series of p(MEMA‐co‐IA) microgels were prepared by modified free‐radical suspension polymerization using ethylene glycol dimethacrylate as cross‐linker. Characterization was performed through FTIR, TGA, DSC, XRD, DLS and SEM. pH responsiveness was evaluated by equilibrium swelling studies in phosphate buffer solutions of different pH values (pH 1.2, 4, 6.5, and 7.4) with constant ionic strength. To demonstrate the potential use of microgels for drug delivery, esomeprazole magnesium trihydrate (EMT) was loaded as model drug and in vitro dissolution studies were performed. FTIR and thermal analysis confirmed the formation of cross‐linked p(MEMA‐co‐IA) microgels. XRD indicated dispersion of drug into the network at molecular level. SEM illustrated smooth, round and uniformly distributed microspheres. A remarkably higher swelling at higher pH values (pH 6.5 and 7.4) compared to pH 1.2 demonstrated the pH‐responsive nature of the microgels. All the formulations showed pH‐dependent drug release following Higuchi with non‐fickian mechanism of drug diffusion. In light of the results obtained from this study, it was concluded that p(MEMA‐co‐IA) microgels have potential to release drug in controlled manner responsive to pH of the external environment.
Synthesis of Iodine‐Substituted Quinolines, Quinolinium Salts, and Isoquinolinium Salts via a Three‐Component Tandem Reaction of Aryl Azides, Propargylic Alcohols, and Iodine
Authors: Wu Yunjun , Shao Min , Feng Zhijun , Gu Xiaoxia , Hong Yi , Cui Qiaoyu , Ren Lianbing , Wang Shaoyin 
Published: November 2016

AbstractAn efficient three‐component tandem reaction of aryl azides, propargylic alcohols, and iodine has been developed. The products of the reaction hinge on the type of the propargylic alcohols: for tertiary alcohols, the reaction proceeded via a cascade Friedel–Crafts‐type reaction/electrophilic cyclization/1,2‐aryl migratory shift sequence to provide 3‐iodoquinolinium salt products, while in the case of secondary alcohols, 3‐iodoquinoline products could be obtained. For aryl azides with certain substituents, this method gave novel isoquinoline skeletons.
Highly Enhanced Fluorescence of Supramolecular Polymers Based on a Cyanostilbene Derivative and Cucurbit[8]uril in Aqueous Solution
Authors: Kim Hyeong‐Ju , Whang Dong Ryeol , Gierschner Johannes , Park Soo Young 
Published: November 2016

AbstractSupramolecular polymers (SPs) have received great attention because of their potential for various practical applications. As part of our search for SPs that are highly fluorescent in aqueous media, we designed a system based on a cucurbit[8]uril (CB[8]) host and a newly designed cyanostilbene guest. Fluorescence quantum yields of ≈0 % in the disassembled monomer state and 91 % in the CB[8]‐induced SP state were obtained. The intriguing photophysical properties of the SP are elucidated through detailed experimental and computational analysis, paving the way towards a fascinating class of water‐soluble fluorescent SPs.
Crystallization of itaconic anhydride grafted poly(lactic acid) during annealing
Authors: Ku Marsilla K. I. , Verbeek C. J. R. 
Published: November 2016

ABSTRACTThe effect of annealing poly(lactic acid) (PLA) and PLA grafted with itaconic anhydride (IA) at different temperatures was studied using differential scanning calorimetry (DSC) and wide angle X‐ray scattering (WAXS). For PLA, two crystal forms were obtained when annealed between 110 and 120 °C, transforming into only the α‐form at 130 °C while a mixture of α′ and α‐form were obtained in grafted PLA. Grafting increased the percentage crystallinity of PLA, but it was mostly unaffected by the degree of grafting. The rate of crystallization was strongly dependent on the degree of grafting; when annealed at 100 °C, the crystallinity increased from 27.7 to 43.1% while the crystallization halftime reduced from 10.7 to 4.4 min at the lowest degree of grafting. It was thought that the increase in crystallization rate was likely due heterogeneous nucleation in the presence of grafted chains. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44614.
Fetal Development of the Incisive Canal, Especially of the Delayed Closure Due to the Nasopalatine Duct: A Study Using Serial Sections of Human Fetuses
Authors: Kim Ji Hyun , Oka Kyoko , Jin Zhe Wu , Murakami Gen , Rodríguez‐Vázquez José Francisco , Ahn Sung Woo , Hwang Hong Pil 
Published: November 2016

ABSTRACTThe incisive canal of the incisive bone or premaxilla is a narrow bony canal through which pass the nasopalatine nerve and its concomitant vessels. However, its fetal development remains obscure. To assess its development, serial frontal sections of the heads of 26 human fetuses, of gestational age 9–20 weeks (crown‐rump length, 46–183 mm), were examined. The nerve initially passed through a wide loose tissue space, but after ossification of the upper part of the incisive bone at 12–15 weeks, the canal became narrow and filled with tight fibrous tissue. Canals in seven fetuses were dilated and open unilaterally or bilaterally. In two of these seven fetuses, a nasopalatine duct passed through the canal and connected the nasal cavity to a central lumen of the paramedian epithelial pearl in the incisive fossa (not to an oral cavity). Even if the canal was closed, the duct was likely to remain above and below the closed part. Paramedian pearls were present in all specimens larger than 110 mm (15 weeks), with or without association of midline pearls. These paramedian pearls usually protruded toward and/or extended into the dilated or open canal, suggesting that these pearls, not any primitive oronasal communication pathway, contributed to keeping the canal open. The dilated canal, located on the superomedial side of the second and third teeth buds, seemed to be usually closed by further ossification. Even in fetuses, the nasopalatine duct seemed to be a variant or unusual phase of development temporally occurring after normal palate fusion. Anat Rec, 300:1093–1103, 2017. © 2016 Wiley Periodicals, Inc.
Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis
Authors: Pianta Annalisa , Arvikar Sheila , Strle Klemen , Drouin Elise E. , Wang Qi , Costello Catherine E. , Steere Allen C. 
Published: November 2016

ObjectivePrevotella copri, an intestinal microbe, may overexpand in stool samples from patients with new‐onset rheumatoid arthritis (RA), but it is not yet clear whether the organism has immune relevance in RA pathogenesis.MethodsHLA–DR–presented peptides (T cell epitopes) from P copri were sought directly in the patients' synovial tissue or peripheral blood mononuclear cell (PBMC) samples using tandem mass spectrometry. The antigenicity of peptides or their source proteins was examined in samples from the RA patients or comparison groups. T cell reactivity was determined by enzyme‐linked immunospot assay; antibody responses were measured by enzyme‐linked immunosorbent assay, and cytokine/chemokine determinations were made by bead‐based assays. Serum and synovial fluid samples were examined for 16S ribosomal DNA for P copri using nested polymerase chain reaction analysis.ResultsIn PBMCs, we identified an HLA–DR–presented peptide from a 27‐kd protein of P copri (Pc‐p27), which stimulated Th1 responses in 42% of patients with new‐onset RA. In both new‐onset RA patients and chronic RA patients, 1 subgroup had IgA antibody responses to either Pc‐p27 or the whole organism, which correlated with Th17 cytokine responses and frequent anti–citrullinated protein antibodies (ACPAs). The other subgroup had IgG P copri antibodies, which were associated with Prevotella DNA in synovial fluid, P copri–specific Th1 responses, and less frequent ACPAs. In contrast, P copri antibody responses were rarely found in patients with other rheumatic diseases or in healthy controls.ConclusionSubgroups of RA patients have differential IgG or IgA immune reactivity with P copri, which appears to be specific for this disease. These observations provide evidence that P copri is immune‐relevant in RA pathogenesis.
Discerning Risk of Disease Transition in Relatives of Systemic Lupus Erythematosus Patients Utilizing Soluble Mediators and Clinical Features
Authors: Munroe Melissa E. , Young Kendra A. , Kamen Diane L. , Guthridge Joel M. , Niewold Timothy B. , Costenbader Karen H. , Weisman Michael H. , Ishimori Mariko L. , Wallace Daniel J. , Gilkeson Gary S. , Karp David R. , Harley John B. , Norris Jill M. , James Judith A. 
Published: November 2016

ObjectiveSystemic lupus erythematosus (SLE) and other autoimmune diseases cause significant morbidity. Identifying populations at risk of developing SLE is essential for curtailing irreversible inflammatory damage. The aim of this study was to identify factors associated with transition to classified disease that would inform our understanding of the risk of SLE.MethodsPreviously identified blood relatives of patients with SLE, who had <4 American College of Rheumatology (ACR) classification criteria for SLE at baseline, were enrolled in this follow‐up study (n = 409 unaffected relatives). Participants provided detailed family, demographic, and clinical information, including the SLE‐specific portion of the Connective Tissue Disease Screening Questionnaire (SLE‐CSQ). Serum and plasma samples were tested for the presence of lupus‐associated autoantibodies and 52 soluble mediators. Generalized estimating equations (GEEs) were applied to identify factors predictive of disease transition.ResultsOf the 409 unaffected relatives of SLE patients, 45 (11%) had transitioned to classified SLE at follow‐up (mean time to follow‐up 6.4 years). Relatives who transitioned to SLE displayed more lupus‐associated autoantibody specificities and higher SLE‐CSQ scores (P < 0.0001) at baseline than did relatives who did not transition. Importantly, those who had developed SLE during the follow‐up period also had elevated baseline plasma levels of inflammatory mediators, including B lymphocyte stimulator, stem cell factor (SCF), and interferon‐associated chemokines (P ≤ 0.02), with concurrent decreases in the levels of regulatory mediators, transforming growth factor β (TGFβ), and interleukin‐10 (P ≤ 0.03). GEE analyses revealed that baseline SLE‐CSQ scores or ACR scores (number of ACR criteria satisfied) and plasma levels of SCF and TGFβ, but not autoantibodies, were significant and independent predictors of SLE transition (P ≤ 0.03).ConclusionPreclinical alterations in levels of soluble mediators may predict transition to classified disease in relatives of SLE patients. Thus, immune perturbations precede SLE classification and can help identify high‐risk relatives for rheumatology referral and potential enrollment in prevention trials.
Use of Amorphous Calcium Carbonate for the Design of New Materials
Authors: Cantaert Bram , Kuo David , Matsumura Shunichi , Nishimura Tatsuya , Sakamoto Takeshi , Kato Takashi 
Published: November 2016

AbstractSince calcium carbonate is one of the most abundant biogenic minerals found in nature, it is no surprise that there has been a huge focus on its formation and use. In this review, we intend to cover the use of amorphous calcium carbonate, which is the most unstable polymorph of calcium carbonate, for the design of new materials. Amorphous calcium carbonate has been used to manipulate the morphology of new materials, and to create strong inorganic/organic hybrid materials based on biological examples. The exoskeletons of crustaceans, sea shell nacre, and brittle star eyes are a few of the examples discussed here, and researchers have looked at these biominerals for the design of new materials. By using polymer additives and organic synthetic layers to substitute for the natural proteins used in biological systems, interesting hybrid materials have been developed. By taking inspiration from this research, new ideas for the design of the fusion materials can be achieved.
Exfoliation of Few‐Layer Graphene in Volatile Solvents Using Aromatic Perylene Diimide Derivatives as Surfactants
Authors: Liscio Andrea , Kouroupis‐Agalou Konstantinos , Kovtun Alessandro , Gebremedhn Elias , El Garah Mohamed , Rekab Wassima , Orgiu Emanuele , Giorgini Loris , Samorì Paolo , Beljonne David , Palermo Vincenzo 
Published: November 2016

AbstractCommercial, aromatic perylene diimide (PDI) dyes were used to exfoliate few‐layer graphene nanosheets in low‐boiling organic solvents such as chloroform and tetrahydrofuran. Importantly, in such solvents, graphene cannot be exfoliated in the absence of the aromatic perylene diimide (PDI) dyes. The PDIs are physisorbed onto the basal plane of the nanosheet surface, which stabilized them in solution; the aromatic core lies flat on graphene and the PDI side groups influenced the physisorption strength and molecular packing. Upon varying just a single atom in the chemical structure of the side groups, significantly different exfoliation efficiencies were observed. The graphene–PDI interaction was studied at the nanoscale by scanning tunneling microscopy and molecular dynamics, at the microscale by atomic force and electron microscopy, and at the macroscale by optical spectroscopy. Thanks to the high volatility of the chosen solvent, the nanosheets can be embedded in standard polymer composites through a simple solvent‐induced swelling procedure.
Detection and Genotyping of Human Papillomaviruses from Archival Formalin‐Fixed Tissue Samples
Authors: Van Doorslaer Koenraad , Chen Zigui , McBride Alison A. 
Published: November 2016

AbstractPathology departments routinely process and store formalin‐fixed, paraffin‐embedded (FFPE) tissue samples for clinical diagnosis. These collections often contain decades’ worth of samples and represent a treasure trove of specimens that can be analyzed for retrospective epidemiological studies, diagnostics, and pathogen discovery. Accurate amplification and sequencing of DNA from these samples is critical for the usability of these FFPE samples. Here we present a collection of protocols that describe extraction of DNA from FFPE tissues, PCR amplification of human papillomavirus DNA, and subsequent genotyping of the infecting virus. © 2016 by John Wiley & Sons, Inc.
Subscribing to fuzzy temporal aggregation of heterogeneous sensor streams in real‐time distributed environments
Authors: Medina J. , Martínez L. , Espinilla M. 
Published: November 2016

SummaryBecause of the deployment of heterogeneous sensors in intelligent environments, the fusion and information processing means an arduous and complex process. The data fusion of sensors and the design of processing information in real time are key aspects in order to generate feasible solutions. In order to shed light on this context, we present an approach for distributing and processing heterogeneous data based on a representation with fuzzy linguistic terms. In this way, the heterogeneous data from sensor streams are computed and summarized based on fuzzy temporal aggregations ubiquitously within mobile and ambient devices. This innovative approach provides an intuitive linguistic representation of mobile and ambient sensors as well as implies a drastic reduction of the communication burden. In order to provide high scalability in network communication, the information from sensor is spread under the publication‐subscription paradigm, where subscribers receive asynchronous events when the aggregation degree of the linguistic terms overcomes a threshold (alpha‐cut). Finally, in order to illustrate the usefulness and effectiveness of our proposal, we present the results of the fuzzy temporal aggregation of sensor streams with alpha‐cut subscriptions in a case study where an inhabitants performs an daily activities in an intelligent environment. Copyright © 2016 John Wiley & Sons, Ltd.
The dynamics of an elastic structure coupled with a rocking wall
Authors: Makris Nicos , Aghagholizadeh Mehrdad 
Published: November 2016

SummaryThis paper investigates the dynamic response of an elastic single‐degree‐of‐freedom oscillator coupled with a rocking wall. Both configurations of a stepping rocking wall and a pinned rocking wall that have been reported in the literature are examined. The full nonlinear equations of motions are derived, and the paper shows through a comprehensive parametric analysis that the coupling with a rocking wall has mixed results on suppressing the dynamic response of the elastic oscillator. The stepping rocking wall is most effective in suppressing displacements of relative flexible structures with a heavier wall being most effective. In contrast, the pinned wall amplifies the displacements along a wide range of the spectrum with a heavier wall being most detrimental. This happens partly because in a pinned wall the moment from its weight works against stability. Copyright © 2016 John Wiley & Sons, Ltd.
A method for integrating neuroimaging into genetic models of learning performance
Authors: Mehta Chintan M. , Gruen Jeffrey R. , Zhang Heping 
Published: November 2016

ABSTRACTSpecific learning disorders (SLD) are an archetypal example of how clinical neuropsychological (NP) traits can differ from underlying genetic and neurobiological risk factors. Disparate environmental influences and pathologies impact learning performance assessed through cognitive examinations and clinical evaluations, the primary diagnostic tools for SLD. We propose a neurobiological risk for SLD with neuroimaging biomarkers, which is integrated into a genome‐wide association study (GWAS) of learning performance in a cohort of 479 European individuals between 8 and 21 years of age. We first identified six regions of interest (ROIs) in temporal and anterior cingulate regions where the group diagnosed with learning disability has the least overall variation, relative to the other group, in thickness, area, and volume measurements. Although we used the three imaging measures, the thickness was the leading contributor. Hence, we calculated the Euclidean distances between any two individuals based on their thickness measures in the six ROIs. Then, we defined the relative similarity of one individual according to the averaged ranking of pairwise distances from the individuals to those in the SLD group. The inverse of this relative similarity is called the neurobiological risk for the individual. Single nucleotide polymorphisms in the AGBL1 gene on chromosome 15 had a significant association with learning performance at a genome‐wide level. This finding was supported in an independent cohort of 2,327 individuals of the same demographic profile. Our statistical approach for integrating genetic and neuroimaging biomarkers can be extended into studying the biological basis of other NP traits.
A novel mechanism of rs763110 polymorphism contributing to cervical cancer risk by affecting the binding affinity of C/EBPβ and OCT1 complex to chromatin
Authors: Wu Shenshen , Wang Shizhi , Fu You , Tang Weiyan , Jin Hua , Meng Qingtao , Zhang Chengcheng , Cui Mengjing , Cao Xiaoli , Li Xiaobo , Zhang Zhengdong , Chen Rui 
Published: November 2016

Recently, several studies have showed that FAS (rs2234767, rs1800682) and FASL (rs763110) functional single nucleotide polymorphisms (SNPs) were associated with the risk of various cancers. However, the association between cervical cancer risk and the three SNPs above remained inconclusive. In this work, we performed a two‐stage case–control study on 1155 cervical cancer patients and 1252 matched healthy controls to determine the roles of the mentioned SNPs in cervical cancer susceptibility. We genotyped the FAS rs2234767, rs1800682, and FASL rs763110 polymorphisms using PCR‐TaqMan assays. Results revealed that the rs763110 TT genotype significantly increased the risk of cervical cancer compared with the CC/CT genotype (adjusted OR = 1.70, 95% CI = 1.19–2.42). However, we did not observe any association between the cervical cancer risk and the rs2234767 and rs1800682 polymorphisms. The immunohistochemistry assay showed that patients carrying the rs763110 TT genotype presented a lower cancerous FASL expression than that of the CC/CT genotypes. Chromatin immunoprecipitation (ChIP) and Sequential Chromatin immunoprecipitation assays also demonstrated that OCT1 was recruited to the FASL promoter region and regulated the FASL gene transcription by interacting with C/EBPβ. In conclusion, this study provided evidence indicating that the rs763110 variant in the FASL promoter was associated with the risk of cervical cancer by affecting the binding affinity of the C/EBPβ/OCT1 complex to chromatin.