bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Frequency 10-kHz Spinal Cord Stimulation Provides Long-term (24-Month) Improvements in Diabetes-Related Pain and Quality of Life for Patients with Painful Diabetic Neuropathy
Authors: Petersen Erika A. , Stauss Thomas G. , Scowcroft James A. , Jaasma Michael J. , Edgar Deborah R. , White Judith L. , Sills Shawn M. , Amirdelfan Kasra , Guirguis Maged N. , Xu Jijun , Yu Cong , Nairizi Ali , Patterson Denis G. , Creamer Michael J. , Galan Vincent , Bundschu Richard H. , Mehta Neel D. , Sayed Dawood , Lad Shivanand P. , DiBenedetto David J. , Sethi Khalid A. , Goree Johnathan H. , Bennett Matthew T. , Harrison Nathan J. , Israel Atef F. , Chang Paul , Wu Paul W. , Argoff Charles E. , Nasr Christian E. , Taylor Rod S. , Caraway David L. , Mekhail Nagy A. 
Published: October 2024

Background: The SENZA-PDN study evaluated high-frequency 10-kHz spinal cord stimulation (SCS) for the treatment of painful diabetic neuropathy (PDN). Over 24 months, 10-kHz SCS provided sustained pain relief and improved health-related quality of life. This report presents additional outcomes from the SENZA-PDN study, focusing on diabetes-related pain and quality of life outcomes. Methods: The SENZA-PDN study randomized 216 participants with refractory PDN to receive either conventional medical management (CMM) or 10-kHz SCS plus CMM (10-kHz SCS + CMM), allowing crossover after six months if pain relief was insufficient. Postimplantation assessments at 24 months were completed by 142 participants with a permanent 10-kHz SCS implant, comprising 84 initial and 58 crossover recipients. Measures included the Brief Pain Inventory for Diabetic Peripheral Neuropathy (BPI-DPN), Diabetes-Related Quality of Life (DQOL), Global Assessment of Functioning (GAF), and treatment satisfaction. Results: Over 24 months, 10-kHz SCS treatment significantly reduced pain severity by 66.9% ( P < .001; BPI-DPN) and pain interference with mood and daily activities by 65.8% ( P < .001; BPI-DPN). Significant improvements were also observed in overall DQOL score ( P < .001) and GAF score ( P < .001), and 91.5% of participants reported satisfaction with treatment. Conclusions: High-frequency 10-kHz SCS significantly decreased pain severity and provided additional clinically meaningful improvements in DQOL and overall functioning for patients with PDN. The robust and sustained benefits over 24 months, coupled with high participant satisfaction, highlight that 10-kHz SCS is an efficacious and comprehensive therapy for patients with PDN.
Preparing for aging: Understanding middle-aged user acceptance of AI chatbots through the technology acceptance model
Authors: Wang Aoqi , Zhou You , Ma Haoming , Tang Xingyi , Li Sijia , Pei Runyuan , Piao Meihua 
Published: October 2024

Background Preparing for aging with personalized technology is crucial due to the growing elderly population. Artificial Intelligence (AI), notably AI chatbots in healthcare, has transformed technology by simulating human-like conversations. Research on middle-aged adults’ acceptance of AI chatbots is limited. Assessing middle-aged individuals’ intentions to use AI is vital for enhancing AI competency among the elderly and guiding future interventions. Objective This study aims to explore the acceptance of middle-aged individuals toward AI chatbots and influencing factors and verify the usability of Technology Acceptance Model 2 (TAM2) in the use of AI technology in middle-aged people, also to inspire the design of future intelligent systems and online interventions for improving the health and well-being of the aging population. Methods A cross-sectional design and snowball sampling method were utilized to conduct an online questionnaire survey among middle-aged adults. The questionnaire was compiled based on TAM2 and was created using the online survey platform. SPSS 26.0 software was used for statistical analysis. Results A total of 259 valid questionnaires were included in the final data analysis. The study reported the Cronbach's α of 0.94 for the questionnaire. We found that perceived ease of use, subjective norm, and user image significantly influence users’ intention to use AI chatbots. Notably, perceived usefulness emerged as a complete mediator in the relationship between subjective norm and intention to use, highlighting its central role in shaping user perceptions. The study also revealed a moderate acceptance level among middle-aged adults, emphasizing the need for targeted interventions. Conclusions This study emphasized the importance of customizing AI technology to improve its adoption among middle-aged adults, providing valuable guidance for developers and policymakers. The findings indicated the need for effective aging preparation that includes technological competency, suggesting that future planning should encompass comprehensive preparations for aging to enhance AI competency among the middle-aged population.
Digital health literacy: A concept analysis
Authors: Ban Suyeon , Kim Yirang , Seomun GyeongAe 
Published: October 2024

Objective To elucidate the concept of digital health literacy by delineating its primary dimensions, origins and effects. Through this clarification, we seek to augment our understanding of the contemporary use of the concept of digital health literacy. Methods Rodgers's concept analysis was employed to investigate digital health literacy as a context-influenced concept evolving with technological progress. Six databases (PubMed, Embase, CINAHL, RISS, KISS and DBpia) and Google Scholar were searched from 2006 to 2023, focusing on the terms ‘digital health literacy’, ‘eHealth literacy’ and ‘mHealth literacy’. Of 2,819 papers, 32 were included in the analysis to identify the conceptual structure of digital health literacy. Results The conceptual structure of digital health literacy was identified, and its evolution was traced. Currently, the four critical attributes are (a) goal-driven regulation, (b) information processing, (c) communication and (d) utilisation. Functional literacy, prior health knowledge and experience, and access to technology are antecedents, while positive health outcomes, increased perceived control and enhanced health-related quality of life emerged as consequences. Additionally, the concept was influenced by multilevel contextual factors. Conclusions By enhancing our understanding of digital health literacy; standardising its terminology; and exploring the interactions among its antecedents, consequences and influencing factors, this study aims to reduce health disparities and promote equitable health in the digital era. The results of this foundational work, which establishes a basis for future research and policy development, provide clear pathways for developing targeted interventions and measurement tools of digital health literacy, ultimately contributing to better health practices.
Engaging with artificial intelligence in mammography screening: Swedish breast radiologists’ views on trust, information and expertise
Authors: Högberg Charlotte , Larsson Stefan , Lång Kristina 
Published: October 2024

Objectives Lack of trust and transparency is stressed as a challenge for clinical implementation of artificial intelligence (AI). In breast cancer screening, AI-supported reading shows promising results but more research is needed on how medical experts, which are facing the integration of AI into their work, reason about trust and information needs. From a sociotechnical information practice perspective, we add to this knowledge by a Swedish case study. This study aims to: (1) clarify Swedish breast radiologists’ views on trust, information and expertise pertaining to AI in mammography screening and (2) analytically address ideas about medical professionals’ critical engagement with AI and motivations for trust in AI. Method An online survey was distributed to Swedish breast radiologists. Survey responses were analysed by descriptive statistical method, correlation analysis and qualitative content analysis. The results were used as foundation for analysing trust and information as parts of critical engagements with AI. Results Of the Swedish breast radiologists ( n = 105), 47 answered the survey (response rate = 44.8%). 53.2% ( n = 25) of the respondents would to a high/somewhat high degree trust AI assessments. To a great extent, additional information would support the respondents’ trust evaluations. What type of critical engagement medical professionals are expected to perform on AI as decision support remains unclear. Conclusions There is a demand for enhanced information, explainability and transparency of AI-supported mammography. Further discussion and agreement are needed considering what the desired goals for trust in AI should be and how it relates to medical professionals’ critical evaluation of AI-made claims in medical decision support.
Enhancing the prediction of the invasiveness of pulmonary adenocarcinomas presenting as pure ground-glass nodules: Integrating intratumor heterogeneity score with clinical-radiological features via machine learning in a multicenter study
Authors: Zheng Hong , Chen Wei , Qi Wanyin , Liu Haibo , Zuo Zhichao 
Published: October 2024

Objective The invasiveness of lung adenocarcinoma significantly impacts clinical decision-making. However, assessing this invasiveness preoperatively, especially when it manifests as pure ground-glass nodules (pGGN) on CT scans, poses challenges. This study aims to quantify intratumor heterogeneity (ITH) and determine whether the ITH score can enhance the accuracy of invasiveness predictions. Methods A total of 524 patients with lung adenocarcinomas presenting as pGGN were enrolled in the study, with 177 (33.78%) receiving a pathologic diagnosis of invasiveness. Four diagnostic approaches were developed to predict the invasiveness of lung adenocarcinoma presenting as pGGN: (1) conventional lesion size, (2) ITH score, (3) clinical-radiological features (ClinRad), and (4) integration of the ITH score with ClinRad. ClinRad alone or in combination with the ITH score served as the input for 11 machine learning approaches. The trained models were evaluated in an independent validation cohort, and the area under the curve (AUC) was calculated to assess classification performance. Results The conventional lesion size showed the lowest performance, with an AUC of 0.826 (95% confidence interval [CI]: 0.758–0.894), while the ITH score outperformed it with an AUC of 0.846 (95% CI: 0.787–0.905). The CatBoost model performed best when the ITH score and ClinRad were both used as input features, leading to the development of an ITH-ClinRad-guided CatBoost classifier. CatBoost also excelled with ClinRad alone, resulting in a ClinRad-guided CatBoost classifier with an AUC of 0.830 (95% CI: 0.764–0.896), surpassed by the ITH-ClinRad-guided CatBoost classifier with an AUC of 0.871 (95% CI: 0.818–0.924). Conclusion The ITH-ClinRad-guided CatBoost classifier emerges as a promising tool with significant potential to revolutionize the management of lung adenocarcinomas presenting as pGGNs.
Effectiveness of Childbirth Self-Efficacy Enhancing Classes on Labor Length and Outcomes among Egyptian Primiparous Women: A Quasi-Experimental Study
Authors: Abd El-Kader Azza Ibrahim 
Published: October 2024

Introduction Childbirth self-efficacy has repeatedly been shown to raise satisfaction with childbirth, reduce the need for analgesic, and promote the use of different childbirth alternatives. However, the measures to improve the childbirth self-efficacy had rarely been investigated among Egyptian primiparous women. Aim The aim of this study is to evaluate the effectiveness of childbirth self-efficacy enhancing classes on labor length and outcomes among Egyptian primiparous women. Methods A quasi-experimental research approach was carried out on prospective, consecutive sample of 148 pregnant women at the end of pregnancy. A prenatal education study group (n = 74) and a control group receiving standard antenatal care (n = 74) make up the first and second groups, respectively. Between October 2021 and October 2022, the study was conducted at the antenatal clinic. The following four tools were employed to fulfill the study's objective: A structured interviewing form, a childbirth self-efficacy inventory, a follow-up checklist for monitoring maternal and neonatal outcomes during labor, and three antenatal education sessions to boost childbirth self-efficacy are all examples of tools that can be used. All statistical analyses were performed using SPSS for windows version 20.0 Results Approximately 68.9% of women in the experimental group gave birth vaginally, compared to 29.7% of those in the control group with (p = .001), according to the study's findings. In the experimental group, regular labor took an average of 8 to 12 h, but it took more than 12 h in the control group. Birth weight (>3000g) in the experimental group compared to (2000–3000 g) in the control group, as well as the Apgar score at 1 min and 5 min, were highly statistically significance between two groups with (p = .001). The means±SD of the childbirth self-efficacy result scores were better in the study group than in control groups regarding length of delivery and vaginal delivery (248.2 ± 19.4 versus 144.6 ± 21.6 and 250.1 ± 18.2 versus 137.9 ± 21.5, respectively). Conclusion According to the findings of this study, antenatal education classes have a real chance of assisting primiparous women in increasing their childbirth self-efficacy and improving maternal and neonatal outcomes.
Ultrasound Shear Wave Elastography of the Arch-Supporting Structures in Symptomatic Flatfoot: A Pilot Study
Authors: Latt L. Daniel , Kim Wonsuk , Caruso Chelsea C. , Krupinski Elizabeth A. , Zuniga Andres Angel Nuncio , Syal Amit , Taljanovic Mihra S. 
Published: October 2024

Background: The posterior tibial tendon (PTT), deltoid ligament, and spring ligament are often torn or attenuated in patients with progressive collapsing foot deformity. The goal of this pilot study was to measure the ultrasound shear wave velocity (SWV) of these arch-supporting structures in feet with varying degrees of deformity to improve our understanding of their role in the progression of deformity. Methods: Two observers measured the SWV of the supramalleolar and inframalleolar PTT in long and short axes, in the tibiospring portion of the deltoid ligament, and in the superomedial band of the spring ligament in 8 neutrally aligned feet, 5 asymptomatic flatfeet, and 7 symptomatic flatfeet. Each measurement was repeated 3 times both with and without an applied eversion stress. Results: Average SWV was lower at all locations in the symptomatic flatfeet compared with normal feet, but these differences were statistically significant only for the inframalleolar PTT and the spring ligament. Externally applied stress led to an increase in the SWV of the ligaments but a paradoxical decrease in the SWV in the supramalleolar PTT. The SWV of the PTT was lower along the short axis compared with the long axis. Conclusion: SWV may be useful in evaluating the severity of degenerative disease of arch-supporting structures, but further study is needed before this technique can be applied clinically. Level of Evidence: Level III, case-control study.
Influence of Multiple Repair Welding on Microstructure and Properties of 06Cr19Ni10 Stainless Steel
Authors: Liu Qimeng , Chang Jingyu , Wang Yuanzhi , Xia Dong , Zhang Jianfei , Guan Xinlong , Zhou Yuwei , Yang Bing 
Published: October 2024

AbstractRepair welding technology is widely used in the manufacturing and maintenance of rail transit equipment to repair welding defects. However, repair welding induces modifications in joint performance, and it is necessary to study the microstructure evolution behavior to reveal the reasons. In this study, the effects of multiple repair welding on the microstructure, mechanical, and fatigue properties of 06Cr19Ni10 stainless steel samples were studied. The surface texture and fracture morphology analyses of the samples were conducted by optical microscopy (OM), scanning electron microscopy (SEM), and its equipped backscattered electron diffraction (EBSD) technique. The mechanical and fatigue properties of the samples with different repair welding times were further obtained by hardness, tensile, and fatigue tests. The results show an increase in the grain size and the substructure content in the heat-affected zone (HAZ), and the austenite orientation is changed, attributable to multiple repair welding. Multiple heat inputs result in a significant increase in hardness from 165 HV to 185 HV, a noticeable decrease in tensile strength and elongation, and an upward trend in yield strength. Under the constant stress level, the heat input of multiple repair welding causes a decrease in the fatigue life and significantly reduces toughness in the instantaneous fracture zone of the secondary repair sample.
Caspase-8 in inflammatory diseases: a potential therapeutic target
Authors: Zhang Wangzheqi , Zhu Chenglong , Liao Yan , Zhou Miao , Xu Wenyun , Zou Zui 
Published: October 2024

AbstractCaspase-8, a renowned cysteine-aspartic protease within its enzyme family, initially garnered attention for its regulatory role in extrinsic apoptosis. With advancing research, a growing body of evidence has substantiated its involvement in other cell death processes, such as pyroptosis and necroptosis, as well as its modulatory effects on inflammasomes and proinflammatory cytokines. PANoptosis, an emerging concept of cell death, encompasses pyroptosis, apoptosis, and necroptosis, providing insight into the often overlapping cellular mortality observed during disease progression. The activation or deficiency of caspase-8 enzymatic activity is closely linked to PANoptosis, positioning caspase-8 as a key regulator of cell survival or death across various physiological and pathological processes. Aberrant expression of caspase-8 is closely associated with the development and progression of a range of inflammatory diseases, including immune system disorders, neurodegenerative diseases (NDDs), sepsis, and cancer. This paper delves into the regulatory role and impact of caspase-8 in these conditions, aiming to elucidate potential therapeutic strategies for the future intervention.
Complete genome sequences of two Pantoea stewartii strains ATCC 8199 from maize and PSCN1 from sugarcane
Authors: Chu Na , Liu Tian-Tian , Zhang Hui-Li , Cui Dong , Huang Mei-Ting , Fu Hua-Ying , Su Jun-Bo , Gao San-Ji 
Published: October 2024

Abstract
Objectives
The pathogen of Pantoea stewartii (Ps) is the causal agent of bacterial disease in corn and various graminaceous plants. Ps has two subspecies, Pantoea stewartii subsp. stewartia (Pss) and Pantoea stewartii subsp. indologenes (Psi). This study presents two complete genomes of Ps strains including ATCC 8199 isolated from maize and PSCN1 causing bacterial wilt in sugarcane. The two bacterial genomes information will be helpful for taxonomy analysis in this genus Pantoea at whole-genome levels and accurately discriminated the two subspecies of Pss and Psi.

Data description
The reference strain ATCC 8199 isolated from maize was purchased from Beijing Biobw Biotechnology Co., Ltd. (China) and the strain of PSCN1 was isolated from sugarcane cultivar YZ08-1095 in Zhanjiang, Guangdong province of China. Two complete genomes were sequenced using Illumina Hiseq (second-generation) and Oxford Nanopore (third-generation) platforms. The genome of the strain ATCC 8199 comprised of 4.78 Mb with an average GC content of 54.03%, along with five plasmids, encoding a total of 4,846 gene with an average gene length of 827 bp. The genome of PSCN1 comprised of 5.03 Mb with an average GC content of 53.78%, along with two plasmids, encoding a total of 4,725 gene with an average gene length of 913 bp. The bacterial pan-genome analysis highlighted the strain ATCC 8199 was clustered into a subgroup with a Pss strain CCUG 26,359 from USA, while the strain PSCN1 was clustered into another subgroup with a Ps strain NRRLB-133 from USA. These findings will serve as a useful resource for further analyses of the evolution of Ps strains and corresponding disease epidemiology worldwide.
The validity and reliability of the Arabic version of the EQ-5D in atrial fibrillation patients in a conflict country: a study from Syria
Authors: Antoun Ibrahim , Alkhayer Alkassem , Aljabal Majed , Alkhayer Alamer , Simon Peter , Mahfoud Yaman , Kotb Ahmed , Barker Joseph , Mavilakandy Akash , Somani Riyaz , Ng G Andre , Zakkar Mustafa 
Published: October 2024

Abstract
Background
The EQ-5D is one of the most commonly used tools to establish health-related quality of life (QoL). EQ-5D data in atrial fibrillation (AF) patients in the Middle East are lacking.

Objectives
This study aims to evaluate the reliability and validity of the Arabic version of the EQ-5D in AF inpatients in Syria.

Methods
The study involved patients admitted to the emergency department of Tishreen’s University Hospital in Latakia with AF as the primary diagnosis between the 1st of June 2021 and the 1st of June 2023. Arabic versions of the EQ-5D, EQ-VAS and SF36 questionnaires were administered to patients. Validation was done using convergent, discriminant, and known-groups validity, while reliability was conducted using EQ-5D retesting within 2–4 weeks.

Results
432 participants were included in the study with a mean ± standard deviation of 63 ± 15. Males represented 242 (56%) of the participants. All hypotheses relating EQ-5D responses to external variables were satisfied. All three validation hypotheses demonstrated that the EQ-5D had the convergent, discriminant and known group validity to assess QoL in this cohort. The intraclass correlation coefficient (ICC) for test-retest reliability ranged between 0.74 and 0.88, while Cohen’s κ ranged between 0.72 and 0.86. Cronbach’s α value for internal consistency was 0.73.

Conclusion
The Arabic version of EQ-5D was valid and reliable in measuring QoL in AF inpatients in Syria. This validation opens the door for more widespread use of the EQ-5D in Arabic-speaking regions, facilitating better-informed healthcare decisions and improving patient care strategies in Syria and other Middle Eastern countries.