bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable Hydrothermal Synthesis of Reduced Graphene Oxide Wrapped on α‐MnO2 Nanorod Cathode for Zinc‐Ion Batteries
Authors: Pradhan Sayli , Ahirrao Dinesh J. , Jha Neetu 
Published: September 2024

AbstractManganese oxide (α‐MnO2) with 1D tunneled cathode material is an attractive option for zinc ion batteries (ZIBs) as it offers high energy efficiency, cost‐effectiveness, natural abundance, safety, and environmental friendliness. However, it possesses inferior conductivity, which compromises its electrochemical performance in practical applications. To address this challenge, the integration of reduced graphene oxide is explored, renowned for its excellent conductivity, with α‐MnO2. This integration enhances the stability and conductivity of the composite structure. The reduction of graphene oxide is achieved through a hydrothermal method, facilitating the wrapping of reduced graphene oxide around α‐MnO2 nanorods. This synthesis approach not only saves energy but also aligns with the intended green approach. In this study, the impact of varying the hydrothermal reaction time on the properties of hydrothermally wrapped reduced graphene oxide on 1D α‐MnO2 (HWGOM) is investigated as a cathode material for ZIBs. A series of samples are prepared with hydrothermal reaction times of 4, 6, and 8 h, respectively. Specifically, HWGOM_6 demonstrates a highest specific capacity of 333 mAh g−1 at the current density of 200 mA g−1, along with remarkable cycling stability, retaining 94.3% of its capacity and achieving a coulombic efficiency of 97% over 500 cycles at a constant current density of 500 mA g−1.
Utility of cerebrovascular imaging biomarkers to detect cerebral amyloidosis
Authors: Howe Matthew D. , Caruso Megan R. , Manoochehri Masood , Kunicki Zachary J. , Emrani Sheina , Rudolph James L. , Huey Edward D. , Salloway Stephen P. , Oh Hwamee ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: September 2024

AbstractINTRODUCTIONThe relationship between cerebrovascular disease (CVD) and amyloid beta (Aβ) in Alzheimer's disease (AD) is understudied. We hypothesized that magnetic resonance imaging (MRI)–based CVD biomarkers—including cerebral microbleeds (CMBs), lacunar infarction, and white matter hyperintensities (WMHs)—would correlate with Aβ positivity on positron emission tomography (Aβ‐PET).METHODSWe cross‐sectionally analyzed data from the Alzheimer's Disease Neuroimaging Initiative (ADNI, N = 1352). Logistic regression was used to calculate odds ratios (ORs), with Aβ‐PET positivity as the standard‐of‐truth.RESULTSFollowing adjustment, WMHs (OR = 1.25) and superficial CMBs (OR = 1.45) remained positively associated with Aβ‐PET positivity (p < 0.001). Deep CMBs and lacunes exhibited a varied relationship with Aβ‐PET in cognitive subgroups. The combined diagnostic model, which included CVD biomarkers and other accessible measures, significantly predicted Aβ‐PET (pseudo‐R2 = 0.41).DISCUSSIONThe study highlights the translational value of CVD biomarkers in diagnosing AD, and underscores the need for more research on their inclusion in diagnostic criteria. ClinicalTrials.gov: ADNI‐2 (NCT01231971), ADNI‐3 (NCT02854033).Highlights
Cerebrovascular biomarkers linked to amyloid beta (Aβ) in Alzheimer's disease (AD).
White matter hyperintensities and cerebral microbleeds reliably predict Aβ‐PET positivity.
Relationships with Aβ‐PET vary by cognitive stage.
Novel accessible model predicts Aβ‐PET status.
Study supports multimodal diagnostic approaches.
Supramolecular Modulation for Selective Mechanochemical Iron‐Catalyzed Olefin Oxidation
Authors: Jiang Chuan , Wu Ye , Zhang Yongjin , Zong Jiawei , Wang Ning , Liu Guohua , Liu Rui , Yu Han 
Published: September 2024

AbstractThe development of a mechanochemical Fe‐catalyzed Wacker oxidation of olefins with a sustainable and benign procedure holds significant promise for industrial applications. However, navigating the intricate interactions inherent in ball‐milling conditions to fine‐tune reaction selectivity remains a formidable challenge. Herein, leveraging the dispersive and/or trapping properties of cyclodextrins, an innovative mechanochemical approach is developed through the integration of cyclodextrins into a Fe‐catalyzed system, enabling a streamlined Wacker oxidation process from simple and/or commercially available alkenes. Our efforts have yielded optimized mechanochemical conditions demonstrating exceptional reactivity and selectivity in generating a diverse array of ketone products, markedly enhancing catalytic efficiency compared to conventional batch methods. Mechanistic investigations have revealed a predominantly Markovnikov‐selective catalytic cycle, effectively minimizing undesired alcohol formation, hydrogenation, and the other competing pathways, boosting both reaction yield and selectivity.
A Strategy for the Formal C−N Cross‐Coupling of Tertiary Amines
Authors: Ledwith Peter R. , Cooney Madelene L. , Bahou Karim A. , García‐Cárceles Javier , Thomson Joshua , Bower John F. 
Published: September 2024

AbstractWe report a strategy for the formal C−N cross‐coupling of tertiary amines via the in situ generation and displacement of N‐acyl ammonium species. Specifically, treatment of diverse tertiary amines with TFAA or chloroformates in the presence of NaI leads to the efficient generation of alkyl iodides, which can be engaged directly in Ni‐catalyzed cross‐couplings. The protocol is applicable to acyclic and cyclic systems, including highly hindered variants. Applications to the late‐stage modification of complex heterocycles are presented.
Radical‐Based Enantioconvergent Reductive Couplings of Racemic Allenes and Aldehydes
Authors: Shen Haigen , Yang Ling , Xu Mingrui , Shi Zhaoxin , Gao Ke , Xia Xiaowen , Wang Zhaobin 
Published: September 2024

AbstractTransition metal‐catalyzed radical‐based enantioconvergent reactions have become a powerful strategy to synthesize enantiopure compounds from racemic starting materials. However, existing methods primarily address precursors with central chirality, neglecting those with axial chirality. Herein, we describe the enantioconvergent reductive coupling of racemic allenes with aldehydes, facilitated by a photoredox, chromium, and cobalt triple catalysis system. This method selectively affords one product from sixteen possible regio‐ and stereoisomers. The protocol leverages CoIII−H mediated hydrogen atom transfer (MHAT) and Cr‐catalyzed radical‐polar crossover for efficient stereoablation of axial chirality and asymmetric addition, respectively. Supported by mechanistic insights from control experiments, deuterium labeling, and DFT calculations, our approach offers synthetic chemists a valuable tool for creating enantioenriched chiral homoallylic alcohols, promising to advance radical‐based strategies for synthesizing complex chiral molecules.
Investigating the impact of water capillary forces on polymer‐substrate adhesion using force spectroscopy
Authors: McClements Jake , Koutsos Vasileios 
Published: September 2024

AbstractAtomic force microscopy (AFM) was used to characterize how water capillary forces impact polymer‐substrate adhesion in ambient conditions. We analyzed hydrophobic poly(styrene‐co‐butadiene) interacting with mica, silicon, and graphite substrates, each with distinct surface properties. Using polymer‐coated AFM tips/blank substrates, and vice versa, we explored the roles of water capillary forces and polymer‐substrate interactions on adhesion. When force spectroscopy experiments were conducted using polymer‐coated tips, adhesion was the largest on mica due to substantial water capillary forces between the tip and hydrophilic substrate. However, when using a blank tip and polymer‐coated substrates, the adhesion was largest on graphite and smallest on mica. This is because the blank tip interacted with the same hydrophobic polymer film for each experiment; therefore, water capillary forces had an equal magnitude on each substrate, allowing polymer‐substrate interactions to be compared even within ambient conditions. Moreover, single‐chain desorption events were consistently observed in these force‐distance curves since water capillary forces were significantly reduced. This study elucidated several aspects of how water capillary forces impact polymer‐substrate adhesion, which benefits applications reliant on polymer adhesion in ambient conditions and contributes to the fundamental understanding of polymer interface interactions.
A molecular design strategy to develop all‐organic crosslinked polyetherimide film with high discharged energy density at 150°C
Authors: Li Chenyang , Yuan Li , Liang Guozheng , Gu Aijuan 
Published: September 2024

AbstractMiniaturization and lightweight of power systems urgently ask for polymer dielectrics with high discharged energy density at 150°C. Herein, a molecular design strategy is built to prepare new crosslinkable polyetherimide films (PEIDx, x is the molar ratio of dianhydride to amines) through simultaneously improving the polarization degree and reducing the residual polarization. Thermal, mechanical, and dielectric properties of PEIDx improve as x increases. PEID0.92 shows the best integrated performances, especially its discharged energy density (5.46 J cm−3, at 10 Hz and 454 MV m−1) is higher than those of reported polymer dielectrics with discharged energy storage at 150°C, and its charge–discharge efficiency is 80.14%. The outstanding energy storage performance of PEID0.92 is attributed to its unique molecular structure. Specifically, the use of nonplanar and low‐alkaline aliphatic cyclic diamine effectively improves the polarization degree of macromolecules; while the crosslinking of alkynyl groups limits the macromolecular movement, thus ensuring high heat resistance and low residual polarization.
Toward the design of highly waterproof‐breathable electrospun nanofiber membrane based on π–π interactions
Authors: Ren Gaihuan , Zhang Yunhe , Nie Gaowei , Li Yiming , Hu Shenpeng , Sun Wen , Li Dongxiang , Cui Zhenhua , Lu Dongxu , Shi Xiaohan , Li Longwei , Yu Hongqin , He Jianxin 
Published: September 2024

AbstractWaterproof and breathable nanofiber membranes are highly desirable for protective textiles; however, the practical application of nanofiber membranes is limited by fluorine‐containing material addition or complicated post‐treatment. Herein, we reported unique fluorine‐free polyurethane (PU)/poly(styrene‐b‐s‐b‐styrene) (SBS) nanofiber membranes by a facile direct electrospinning. Owing to the addition of SBS, the hydrophobicity, waterproofness, and mechanical properties of PU nanofiber membranes were dramatically enhanced. Furthermore, the highly interconnective channels were constructed after the introduction of SBS into the PU nanofiber membrane, which resulted in enhanced breathability. The enhancement in the comprehensive performance of the PU/SBS composite nanofiber membrane might be attributed to the π–π interactions between SBS and PU. By adjusting the concentration of the PU/SBS, fluorine‐free PU/SBS nanofiber membranes were optimized systematically, exhibiting satisfactory waterproofness (hydrostatic pressure, 47.4 kPa), acceptable breathability (water vapor transition rate, 5.6 kg m−2 d−1), and outstanding mechanical properties (breaking strength, 5.7 MPa; breaking elongation, 387.9%). The PU/SBS‐14 nanofiber membrane is ideal for wearable textiles, especially for outdoor protective clothing, wound dressings, and medical gowns.
What triggers people to buy green products?: Empirical evidence from an emerging market
Authors: Kaur Ravinder , Yadav Shivani , Mishra Suyash 
Published: September 2024

AbstractEscalating awareness of consumers on environmental issues have not translated into demand for green products in emerging economies, resulting in a rising need for further research on green purchasing behaviour. Considering this gap, the current study investigates the association of eco‐label and environmental knowledge with green purchase behaviour, and explores the mediating impact of environmental attitude and green trust. In addition, this study examines the moderating role of perceived price in influencing such behaviour. The proposed research model is empirically tested with data collected from 600 customers in India. The results indicate that eco‐label, environmental knowledge, green trust, and environmental attitude are significantly associated with green purchase behaviour. Further, environmental attitude does not mediate the association between eco‐label and green purchasing behaviour, while this link is partially mediated by green trust. In comparison, environmental attitude plays a partial mediating role between green trust and green purchasing behaviour. Moreover, perceived price moderates the relationship between environmental attitude and green purchase behaviour positively, while negatively moderates the relationship of green purchase behaviour with green trust. The findings help to draw significant implications for environmental and green marketers, along with a better knowledge of the complicated consumer behaviour associated with the purchase of green products, which will ultimately help them to develop more viable green marketing strategies in India. Overall, this research will enhance the green marketing literature by providing insights into how marketers and businesses can trigger the green purchasing by consumers in emerging market.
Perioperative toripalimab plus neoadjuvant chemotherapy might improve outcomes in resectable esophageal cancer: an interim analysis of a phase III randomized clinical trial
Authors: Zheng Yan , Liang Guanghui , Yuan Dongfeng , Liu Xianben , Ba Yufeng , Qin Zimin , Shen Sining , Li Zhenxuan , Sun Haibo , Liu Baoxing , Gao Quanli , Li Peng , Wang Zongfei , Liu Shilei , Zhu Jianping , Wang Haoran , Ma Haibo , Liu Zhenzhen , Zhao Fei , Zhang Jun , Zhang He , Wu Daoyuan , Qu Jinrong , Ma Jie , Zhang Peng , Ma Wenjie , Yan Ming , Yu Yongkui , Li Qing , Zhang Jiangong , Xing Wenqun 
Published: September 2024

AbstractBackgroundIn the era of immunotherapy, neoadjuvant immunochemotherapy (NAIC) for the treatment of locally advanced esophageal squamous cell carcinoma (ESCC) is used clinically but lacks of high‐level clinical evidence. This study aimed to compare the safety and long‐term efficacy of NAIC followed by minimally invasive esophagectomy (MIE) with those of neoadjuvant chemotherapy (NAC) followed by MIE.MethodsA prospective, single‐center, open‐label, randomized phase III clinical trial was conducted at Henan Cancer Hospital, Zhengzhou, China. Patients were randomly assigned to receive either neoadjuvant toripalimab (240 mg) plus paclitaxel (175 mg/m2) + cisplatin (75 mg/m2) (toripalimab group) or paclitaxel + cisplatin alone (chemotherapy group) every 3 weeks for 2 cycles. After surgery, the toripalimab group received toripalimab (240 mg every 3 weeks for up to 6 months). The primary endpoint was event‐free survival (EFS). The pathological complete response (pCR) and overall survival (OS) were key secondary endpoints. Adverse events (AEs) and quality of life were also assessed.ResultsBetween May 15, 2020 and August 13, 2021, 252 ESCC patients ranging from T1N1‐3M0 to T2‐3N0‐3M0 were enrolled for interim analysis, with 127 in the toripalimab group and 125 in the chemotherapy group. The 1‐year EFS rate was 77.9% in the toripalimab group compared to 64.3% in the chemotherapy group (hazard ratio [HR] = 0.62; 95% confidence interval [CI] = 0.39 to 1.00; P = 0.05). The 1‐year OS rates were 94.1% and 83.0% in the toripalimab and chemotherapy groups, respectively (HR = 0.48; 95% CI = 0.24 to 0.97; P = 0.037). The patients in the toripalimab group had a higher pCR rate (18.6% vs. 4.6%; P = 0.001). The rates of postoperative Clavien‐Dindo grade IIIb or higher morbidity were 9.8% in the toripalimab group and 6.8% in the chemotherapy group, with no significant difference observed (P = 0.460). The rates of grade 3 or 4 treatment‐related AEs did not differ between the two groups (12.5% versus 12.4%).ConclusionsThe interim results of this ongoing trial showed that in resectable ESCC, the addition of perioperative toripalimab to NAC is safe, may improve OS and might change the standard treatment in the future.
Tryptophan 2,3‐dioxygenase‐positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine‐mediated ferroptosis resistance of metastatic cells and T cell dysfunction
Authors: Liu Yongcan , Chen Shanchun , Wan Xueying , Wang Rui , Luo Haojun , Chang Chao , Dai Peijin , Gan Yubi , Guo Yuetong , Hou Yixuan , Sun Yan , Teng Yong , Cui Xiaojiang , Liu Manran 
Published: September 2024

AbstractBackgroundTumor metastasis is a major threat to cancer patient survival. The organ‐specific niche plays a pivotal role in tumor organotropic metastasis. Fibroblasts serve as a vital component of the metastatic microenvironment, but how heterogeneous metastasis‐associated fibroblasts (MAFs) promote organotropic metastasis is poorly characterized. Here, we aimed to decipher the heterogeneity of MAFs and elucidate the distinct roles of these fibroblasts in pulmonary metastasis formation in breast cancer.MethodsMouse models of breast cancer pulmonary metastasis were established using an in vivo selection method of repeated injections of metastatic cells purified from the mouse lung. Single‐cell RNA‐sequencing (scRNA‐seq) was employed to investigate the heterogeneity of MAFs. Transgenic mice were used to examine the contribution of tryptophan 2,3‐dioxygenase‐positive matrix fibroblasts (TDO2+ MFs) in lung metastasis.ResultsWe uncovered 3 subtypes of MAFs in the lung metastatic microenvironment, and their transcriptome profiles changed dynamically as lung metastasis evolved. As the predominant subtype, MFs were exclusively marked by platelet‐derived growth factor receptor alpha (PDGFRA) and mainly located on the edge of the metastasis, and T cells were enriched around MFs. Notably, high MF signatures were significantly associated with poor survival in breast cancer patients. Lung metastases were markedly diminished, and the suppression of T cells was dramatically attenuated in MF‐depleted experimental metastatic mouse models. We found that TDO2+ MFs controlled pulmonary metastasis by producing kynurenine (KYN), which upregulated ferritin heavy chain 1 (FTH1) level in disseminated tumor cells (DTCs), enabling DTCs to resist ferroptosis. Moreover, TDO2+ MF‐secreted chemokines C‐C motif chemokine ligand 8 (CCL8) and C‐C motif chemokine ligand 11 (CCL11) recruited T cells. TDO2+ MF‐derived KYN induced T cell dysfunction. Conditional knockout of Tdo2 in MFs diminished lung metastasis and enhanced immune activation.ConclusionsOur study reveals crucial roles of TDO2+ MFs in promoting lung metastasis and DTCs’ immune evasion in the metastatic niche. It suggests that targeting the metabolism of lung‐specific stromal cells may be an effective treatment strategy for breast cancer patients with lung metastasis.
Fortunefuroic Acid J from Keteleeria Hainanensis and its Dual Inhibitory Effects on ATP‐Citrate Lyase and Acetyl‐CoA Carboxylase.
Authors: Zhao Ze‐Yu , Zang Yi , Li Jia , Choo Yeun‐Mun , Xiong Juan , Hu Jin‐Feng 
Published: September 2024

AbstractA previously undescribed triterpenoid (fortunefuroic acid J, 1) was isolated from the endangered conifer Keteleeria hainanensis, along with 20 other known terpenoids. Compound 1 is characterized by an unusual 3,4‐seco‐9βH‐lanost‐3‐oic acid motif, featuring a rare furoic acid moiety in its lateral chain. The structure elucidation of this compound was achieved through a combination of spectroscopic and computational methods. The C‐15 epimers of 15‐methoxypinusolidic acid (15R‐8 and 15S‐9) were successfully separated and identified for the first time. Compound 1 demonstrated dual inhibitory effects against ATP‐citrate lyase (ACL, IC50: 0.92 μM) and acetyl‐CoA carboxylase 1 (ACC1, IC50: 10.76 μM). Compounds 2 and 11 exclusively inhibited ACL, exhibiting IC50 values of 2.64 and 6.35 μM, respectively. Compound 1 is classified among the fortunefuroic acid‐type compounds, previously isolated from K. fortunei, distinguished by the presence of a rare furoic acid moiety in their lateral chain. The chemotaxonomic significance of the 9βH‐lanost‐26‐oic acids in Keteleeria was briefly discussed. These findings highlight the importance of conserving plant species diversity, thereby enhancing the exploration of structurally diverse compounds and potential avenues for developing new therapeutics targeting ACL/ACC1‐associated diseases.
Essential Oils from the Leaves and Stem Barks of Pluchea Indica (L.) Less.: Chemical Analysis, Cytotoxicity, Anti‐inflammation, Antimicrobial Activity, Molecular Docking, and ADMET Profiling
Authors: Trang Vu Minh , Son Ninh The , Pham Ty Viet , Giang Phan Minh 
Published: September 2024

AbstractPluchea indica (L.) Less. is a medicinal plant native to Asia. Traditionally, it is known for numerous traditional uses, such as treatments for fever, cough, and digestive issues. The present investigation aims to determine the chemical compositions of essential oils from its fresh leaves and stem barks. By using hydro‐distillation and the GC‐FID/MS (gas chromatography‐flame ionization detection/mass spectrometry) analysis, the studied samples were dominated by sesquiterpene hydrocarbons (76.8–82.2 %) and their oxygenated derivatives (8.4–19.0 %). β‐Selinene (42.0–43.5 %) and silphinene (21.1–22.9 %) were the main compounds. Significantly, the stem bark essential oil strongly monitored the growth of four cancer cell lines K562, HeLa, HepG2, and MCF‐7 with IC50 values of 2.89–7.34 μg/mL. Both studied samples showed strong anti‐inflammatory activity against NO (nitric oxide) production with IC50 values of 21.81–23.18 μg/mL. The studied sample also exhibited antimicrobial activity at different levels. The molecular docking study revealed that β‐selinene exhibited the strongest binding affinity for all four cancer‐related protein targets: epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), Abelson tyrosine–protein kinase 1 (ABL1), and phosphatidylinositol 3‐kinase (PI3 K‐α). The ADMET profiles of the major compounds were also predicted to provide insights for further research considerations.
Left atrial septal pouch thrombus: An unusual cause of an embolic stroke
Authors: Bhave Aditya , Patel Aditya , Patel Raag , Barmore Walker , Siddu Mithilesh , Switzer Jeffrey , Yirerong Juliet , Sharma Gyanendra 
Published: September 2024

Key Clinical MessageLeft‐atrial septal pouch (LASP) is a newly described anatomical variant caused by incomplete fusion of the septa primum and secundum. This case visualizes LASP as a potential nidus for blood stasis and cardiac embolism and highlights the need for consideration of TEE in the work up of cryptogenic stroke.