bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommendations for Future Interdisciplinary Collaborations Within Transport and Mobility
Authors: Ryghaug Marianne , Skjølsvold Tomas Moe , Keseru Imre , Basu Samyajit 
Published: October 2024

AbstractThis book explores the potential of interdisciplinary collaborations between Social Sciences and Humanities (SSH) and Science, Technology, Engineering, and Mathematics (STEM) to address challenges in transport and mobility. Through a series of experimental research teams, the authors aimed to integrate diverse disciplinary insights to produce innovative policy recommendations. Despite encountering difficulties and traditional disciplinary boundaries, the project highlights the importance of institutional support, adequate resources, and long-term commitment to fostering effective interdisciplinary research. The concluding chapter reflects on these experiences and offers recommendations for enhancing future interdisciplinary efforts in this field.
Subsurface Microbial Colonization at Mineral-Filled Veins in 2-Billion-Year-Old Mafic Rock from the Bushveld Igneous Complex, South Africa
Authors: Suzuki Yohey , Webb Susan J. , Kouduka Mariko , Kobayashi Hanae , Castillo Julio , Kallmeyer Jens , Moganedi Kgabo , Allwright Amy J. , Klemd Reiner , Roelofse Frederick , Mapiloko Mabatho , Hill Stuart J. , Ashwal Lewis D. , Trumbull Robert B. 
Published: October 2024

AbstractRecent advances in subsurface microbiology have demonstrated the habitability of multi-million-year-old igneous rocks, despite the scarce energy supply from rock-water interactions. Given the minimal evolution coupled with exceedingly slow metabolic rates in subsurface ecosystems, spatiotemporally stable igneous rocks can sustain microbes over geological time scales. This study investigated a 2-billion-year-old mafic rock in the Bushveld Igneous Complex, South Africa, where ultradeep drilling is being executed by the International Continental Scientific Drilling Program (ICDP). New procedures were successfully developed to simultaneously detect indigenous and contaminant microbial cells in a drill core sample. Precision rock sectioning coupled with infrared, fluorescence, and electron microscopy imaging of the rock section with submicron resolution revealed microbial colonization in veins filled with clay minerals. The entry and exit of microbial cells in the veins are severely limited by tight packing with clay minerals, the formation of which supplies energy sources for long-term habitability. Further microbiological characterization of drilled rock cores from the Bushveld Igneous Complex will expand the understanding of microbial evolution in deep igneous rocks over 2 billion years.
TRPC4/5 inhibitors: Phase I results and proof of concept studies
Authors: Grimm Simone , Just Stefan , Fuertig Rene , Dwyer Jennifer B. , Sharma Vikas M. , Wunder Andreas 
Published: September 2024

AbstractTransient receptor potential canonical (TRPC) ion channels are expressed in areas of the brain responsible for processing emotion and mood and have been implicated in the pathophysiology of internalizing disorders such as major depressive disorder and anxiety disorders. This review outlines the rationale for targeting TRPC ion channels for drug development, with specific focus on TRPC4 and TRPC5. We provide preclinical evidence that the lack of TRPC4 and TRPC5 channels or its pharmacological inhibition attenuate fear and anxiety without impairing other behaviors in mice. We also report on clinical studies of BI 1358894, a small molecule inhibitor of TRPC4/5 ion channels, demonstrating reduced psychological and physiological responses to induced anxiety/panic-like symptoms in healthy volunteers. Furthermore, we highlight an imaging study that investigated the acute effects of BI 1358894 and showed reduced activation in several brain regions involved in emotional processing. We conclude that these findings demonstrate a critical role for TRPC4 and TRPC5 in emotional processing, even though it remains an open question if the biological signatures of TRPC4/5 inhibition reported here translate into clinical efficacy and indicate that a TRPC4/5 inhibitor might provide a more effective treatment of internalizing disorders.
Synaptic basis of rapid antidepressant action
Authors: Kavalali Ege T. , Monteggia Lisa M. 
Published: September 2024

AbstractThe discovery of ketamine’s rapid antidepressant action has generated intense interest in the field of neuropsychiatry. This discovery demonstrated that to alleviate the symptoms of depression, treatments do not need to elicit substantive alterations in neuronal circuitry or trigger neurogenesis, but rather drive synaptic plasticity mechanisms to compensate for the underlying pathophysiology. The possibility of a rapidly induced antidepressant effect makes therapeutic pursuit of fast-acting neuropsychiatric medications against mood disorders plausible. In the meantime, the accumulating clinical as well as preclinical observations raise critical questions on the nature of the specific synaptic plasticity events that mediate these rapid antidepressant effects. This work has triggered the current growing interest in alternative psychoactive compounds that are thought to have similar properties to ketamine and its action. This review covers our insight into these questions based on the work our group has conducted on this topic in the last decade.
β-Citronellol: a potential anti-inflammatory and gastro-protective agent-mechanistic insights into its modulatory effects on COX-II, 5-LOX, eNOS, and ICAM-1 pathways through in vitro, in vivo, in silico, and network pharmacology studies
Authors: Iqbal Urooj , Malik Abdul , Sial Nabeela Tabassum , Mehmood Malik Hassan , Nawaz Shoaib , Papadakis Marios , Fouad Dalia , Ateyya Hayam , Welson Nermeen N. , Alexiou Athanasios , Batiha Gaber El-Saber 
Published: September 2024

Abstract
Background
The current study aimed to evaluate the anti-inflammatory, anti-oxidant, and pronounced gastro-protective activities of β- Citronellol using in vitro, in vivo assays and in silico approaches.

Methods
In vitro assays, denaturation of bovine serum albumin, egg protein, and human Red Blood Cells (RBCs) membrane stabilization were performed, using Piroxicam as standard. For in vivo assessment, Histamine (0.1 ml from 1% w/v) and Formaldehyde (0.1 ml from 2% v/v) were used to mediate inflammation. In silico molecular docking and network pharmacology were employed to probe the possible target genes mediating gastroprotective effect of β-Citronellol at 25, 50, and 100 mg/kg, using indomethacin-induced (25 mg/kg i.p) gastric ulcer in rats. Moreover, Gastric tissues were evaluated for morphological, histopathological, and bio-chemical analysis of PGE2, COX-I, COX-II, 5-LOX, eNOS, ICAM-1, oxygen-free radical scavengers (SOD, CAT), and oxidative stress marker (MDA).

Results
β-Citronellol prevented denaturation of proteins and RBCs membrane stabilization with maximum effect observed at 6,400 µg/mL. Citronellol decreased rat’s paw edema. Network pharmacology and docking studies revealed gastro-protective potential of Citronellol possibly mediated through arachidonic acid pathways by targeting COX-I, COX-II, PGE2, and 5-LOX. Citronellol reduced the ulcer indices, and histopathological changes. Further, β-Citronellol (50 and 100 mg/kg) increased gastric PGE2, COX-1, and eNOS; while suppressing COX-2, 5-LOX and ICAM-1. Citronellol markedly enhanced the oxidative balance in isolated rat stomach tissues.

Conclusions
The anti-inflammatory, anti-oxidant, and gastro-protective effects of β-Citronellol against indomethacin-induced gastric ulcer model in rats through mediating COX-I, COX-II, PGE2, 5-LOX, eNOS, and ICAM-1 inflammatory markers.

Graphical abstract
The narrative that should guide applied behavioural science
Authors: Dold Malte 
Published: October 2024

Abstract
This article serves as a commentary on Michael Hallsworth's 2023 piece, ‘A manifesto for applying behavioural science,’ featured in Nature Human Behaviour. The manifesto was prompted by methodological, practical and normative critiques directed at behavioural science and its role in public policy. In this commentary, I argue that the manifesto presents numerous insightful and constructive reform proposals regarding the scope, methods and values in behavioural science, which can help advance the field of behavioural public policy. While there is much to agree with, I contend in this commentary that applied behavioural science can and should delve deeper into the study of socially and culturally embedded processes of goal formation. Additionally, it should explore the institutional conditions necessary for individuals to formulate their goals competently and in a self-determined manner.
Healthcare Cost of Multiple Sclerosis and in Relation to Disability Level in Alberta
Authors: McCombe Jennifer A. , Smyth Penelope , Kate Mahesh , So Helen , Vu Khanh , Luu Huong , Martins Karen J.B. , Aponte-Hao Sylvia , Nguyen Phuong Uyen , Richer Lawrence , Williamson Tyler , Klarenbach Scott W. 
Published: October 2024

ABSTRACT

Background:
We aimed to (1) report updated estimates of direct healthcare costs for people living with MS (pwMS), (2) contrast costs to a control population and (3) explore differences between disability levels among pwMS.

Methods:
Administrative data were used to identify adult pwMS (MS cohort) and without (control cohort) in Alberta, Canada; disability level (based on the Expanded Disability Status Scale) among pwMS was estimated. One- and two-part generalized linear models with gamma distribution were used to estimate the incremental direct healthcare cost (2021 $CDN) of MS during a 1-year observation period.

Results:
Adjusting for confounders, the total healthcare cost ratio was higher in the MS cohort (n = 13,089) versus control (n = 150,080) (5.24 [95% CI: 5.08, 5.41]) with a predicted incremental cost of $15,016 (95% CI: $14,497, $15,535) per person-year. Among the MS cohort, total predicted direct healthcare costs were higher with greater disability, $14,430 (95% CI: $13,980, $14,880) to $58,697 ($51,514, $65,879) per person-year in mild and severe disability, respectively. The primary health resource cost component shifted from disease-modifying therapies in mild disability to supportive care in moderate and severe disability.

Conclusion:
Adult pwMS had greater direct healthcare costs than those without. Extrapolating to the population level (where 14,485 adult pwMS were identified in the study), it is estimated that $218 million per year in healthcare costs may be attributable to MS in Alberta. The significantly larger economic impact associated with greater disability underscores the importance of preventing or delaying disease progression and functional impairment in MS.
A schema for coding health equity scholarship within pediatric research
Authors: Abdi Najma , Tso Sabrina W. , Roduin Cheyenne , Nylander Elisabeth , Jones Amanda L. , Groshong Susan L. , Paulsen Julia , Saelens Brian E. 
Published: October 2024

Abstract

Introduction:
Seattle Children’s Research Institute is identifying the amount and type of health equity scholarship being conducted institution wide. However, methods for categorizing how scholarship is equity-focused are lacking. We developed and evaluated the reliability of a health equity scholarship coding schema applied to Seattle Children’s affiliated scholarship.

Methods:
A 2021–2022 Ovid MEDLINE affiliation search yielded 3551 affiliated scholarship records, with 1079 records identified via an existing filter as scholarship addressing social determinants of health. Through reliability testing and examining concordance and discordance across three independent coders of these records, we developed a coding schema to classify health equity scholarship (yes/no). When health equity scholarship proved positive/Yes, the coders assigned a one through five maturity rating of the scholarship towards addressing inequities. Subsequent reliability testing including a new coder was conducted for 992 subsequent affiliated scholarship records (Oct 2022–June 2023), with additional testing of the sensitivity and specificity of the existing filter relative to the new coding schema.

Results:
Reliability for identifying health equity scholarship was consistently high (Fleiss kappas ≥ .78) and categorization of health equity scholarship into maturity levels was moderate (Fleiss kappas ≥ .47). The coding schema identified additional health equity scholarship not captured in an existing filter for social determinants of health scholarship. Based on the new schema, 23.3% of Seattle Childrens’ affiliated scholarship published October 2002–June 2023 was health equity focused.

Conclusions:
This new coding schema can be used to identify and categorize health equity scholarship to help quantitate the health equity focus of portfolios of human-focused research.
Chinese mothers use idioms in shared book reading: A predictor for children’s Chinese vocabulary growth?
Authors: Yang Junyi , Grøver Vibeke , Lawrence Joshua F. 
Published: October 2024

Abstract
Idioms play an important role in language; however, little research has examined idioms in children’s natural language settings. This study explored idioms usage in maternal talk during mother-child shared book reading and its relation to children’s vocabulary development. Thirty-three Chinese children in Norway (aged 3;0–5;5) and their mothers participated. We observed shared reading at the onset of the study and assessed children’s receptive and expressive vocabulary in Chinese three times across one year. Results demonstrated that mothers used an average of 1.8 idioms and explained one-third of the idioms. Maternal idiom usage was correlated with their talk amount and lexical diversity. Individual growth modeling revealed that the number of idioms mothers used predicted the growth of children’s receptive vocabulary in Chinese. We speculate that idiom usage could be an effective and understudied marker of parental linguistic sophistication. This study underscores the importance of idiom exposure in children’s language environment.
Experiential, perceptual, and cognitive individual differences in the development of declarative and automatized phonological vocabulary knowledge
Authors: Saito Kazuya , Uchihara Takumi 
Published: October 2024

Abstract
The present study explores the influence of individual differences in experience, perceptual acuity, and working memory on the development of both declarative and automatized aspects of L2 phonological vocabulary knowledge. A total of 486 Japanese English-as-a-foreign-language (EFL) students took part in two vocabulary tests designed to measure declarative (meaning recognition) and automatized knowledge (lexicosemantic judgement task). Their performance was tied to the quantity and quality of their EFL experience, as well as their scores in auditory processing and working memory. While several significant, modest correlations between experience, aptitude, and vocabulary outcomes were observed, certain predictor variables were uniquely associated with either declarative or automatized vocabulary performance. Specifically, individuals with more extensive, typically language-focused EFL training and greater working memory demonstrated higher levels of declarative knowledge. Conversely, those who pursued extracurricular practice outside the classroom – exposing themselves to auditory materials and/or participating in study-abroad experiences – showed a more automatic execution of vocabulary knowledge.
Monitoring sodium content in processed and ultraprocessed foods in Argentina 2022: compliance with National Legislation and Regional Targets
Authors: Guarnieri Leila , Castronuovo Luciana , Flexner Nadia , Yang Yahan , L’Abbe Mary R , Tiscornia Victoria 
Published: October 2024

Abstract

Objective:
To assess the current Na levels in a variety of processed food groups and categories available in the Argentinean market to monitor compliance with the National Law and to compare the current Na content levels with the updated Pan American Health Organisation (PAHO) regional targets.

Design:
Observational cross-sectional study.

Setting and Participants:

Argentina. Data were collected during March 2022 in the city of Buenos Aires in two of the main supermarket chains. We carried out a systematic survey of pre-packaged food products available in the food supply assessing Na content as reported in nutrition information panels.

Results:
We surveyed 3997 food products, and the Na content of 760 and 2511 of them was compared with the maximum levels according to the Argentinean law and the regional targets, respectively. All food categories presented high variability of Na content. More than 90 % of the products included in the National Sodium Reduction Law were found to be compliant. Food groups with high median Na, such as meat and fish condiments, leavening flour and appetisers are not included in the National Law. In turn, comparisons with PAHO regional targets indicated that more than 50 % of the products were found to exceed the regional targets for Na.

Conclusions:
This evidence suggests that it is imperative to update the National Sodium Reduction Law based on regional public health standards, adding new food groups and setting more stringent legal targets.
Whose war is it anyway? Proportionate reparations in wars of aggression
Authors: Nizami Ameer Arnaaz 
Published: October 2024

Abstract
This article proposes a hybrid legal framework combining jus ad bellum and jus in bello to govern the attribution of State responsibility for reparations at the end of a war of aggression. To this end, the article considers former international mass claims processes and proposes a complementary approach that, on the one hand, acknowledges the role of the aggressor State in waging the war, and on the other, takes a cautionary approach to prevent a disproportionate burden of compensation being imposed on the aggressor State as a form of collective punishment. The consequences of respective violations of the prohibition of the use of force and the law of war are blurred in a war of aggression, resulting in complexities around liability for aggressor States. In response, this article concludes with a nuanced proposal to calculate compensation based on (1) the aggressor party's capacity to comply with jus in bello; (2) the extent of damage caused by the war of aggression, factoring in jus ad bellum considerations if a party is found to be intentionally maximizing destruction; and (3) the incorporation of tort law principles for equitable attribution of responsibility.
Towards common ground: Strategies for effective collaboration between the humanitarian and peacebuilding communities
Authors: Brubaker Rebecca , Bennett Will , Eriksen Hannah Ajelet 
Published: October 2024

Abstract
In an era marked by growing conflicts, prolonged humanitarian needs and less donor funding, collaboration between the humanitarian and peacebuilding sectors is essential for more effective responses. This paper examines the complexities of fostering such collaboration, emphasizing the importance of integrated multisectoral approaches capable of addressing both immediate necessities and long-term peace and development objectives. While recent initiatives such as the humanitarian–development–peace nexus framework and the United Nations Secretary-General's Agenda for Humanity reflect progress toward integrated approaches, substantial collaborative challenges persist. This paper identifies three key entry points for mutual learning between humanitarian and peace actors. Firstly, it discusses a “peace-responsive” approach to humanitarian activities that proactively contributes to “peace-positive” outcomes. Secondly, it emphasizes the need for the peace sector to learn from humanitarian efforts regarding accountability to affected communities. Thirdly, it underscores the need to understand the normative foundations of each sector and their implications for joint action. Drawing on these insights, the paper offers recommendations for policy-makers and practitioners to help them advance joint approaches to humanitarian assistance and peacebuilding in conflict-affected contexts.
Mineralogical and radiological studies on some Paleozoic yellow ochre deposits in Southwestern Sinai, Egypt
Authors: Abdel-Azeem Marwa M. , Harpy Nareman M. , Alshami Abdalla S. , Maadawy Wael M. El 
Published: October 2024

AbstractYellow ochre is the basic material used in the manufacture of yellow oxide (a commercial product). Yellow ochre samples were taken from three different formations in southwestern Sinai: Abu Hamata, Um Bogma, and Abu Zarab. Yellow ochre occasionally exists in Abu Hamata Formation particularly in El Ferah area, associated with Fe–Mn ore in Wadi El Sahu (Um Bogma Formation) and in Himayer area (Abu Zarab Formation). The XRD analysis of the raw material reveals that they are mainly composed of goethite, which is associated with quartz and kaolinite in El Ferah area, hematite, kaolinite and quartz in Himayer area, and kaolinite, gypsum and quartz in Wadi El Sahu. The commercial product is mainly composed of goethite, quartz, and calcite. The heavy mineral investigation shows that some yellow ochre samples contain zircon and rare earth sulfate which may be responsible for the radioactivity of ochre due to their thorium and uranium content. The average values of specific radio-activities of most radionuclides in the samples of Himayer area I and II, and El Sahu I are higher than the respective world averages, while their activities are lower in El Ferah and El Sahu II. Th/U and Ra/U ratios exhibit vigorous changes in physico-chemical conditions during uranium leaching and deposition. Most of the radiological parameters in the ferruginous sediment and commercial product samples from El Ferah, El Sahu II, and Himayer II are lower than the recommended international values but higher than those from Himayer I and El Sahu I samples. The plotted hierarchical cluster analysis (HCA) exhibits that the main contributors for the hazards of these sediments and their commercial product are 238U, 232Th and 226Ra in Himayer I &II, commercial products, and El Ferah area, 232Th and 226Ra in El Sahu II , 232Th, 40K and 226Ra in El Sahu I.
Folded flexure MOEMS for the detection of PSA and hepatitis DNA as biosensor for prostate cancer and viruses
Authors: Bahramian Hossein , Gholinejad Jalal , Yazdanpanah Goharrizi Arash 
Published: October 2024

AbstractMicro-opto-electro-mechanical systems (MOEMS) biosensors are employed in various applications such as disease monitoring, drug investigation, detection of pollutants, and biological fluid studies. In this paper, a novel MOEMS biosensor based on a differential folded-flexure structure is introduced. The designed device is employed to detect prostate-specific antigen (PSA) protein and Hepatitis DNA. The target molecules cause a mechanical deflection in the folded-flexure; subsequently, the transmitted optical power across the finger, attached to the flexure, is modulated in proportion to the input concentration. Then, a photodiode power sensor measures the modulated optical power, where the output of the sensor is simply a current related to the target molecules’ concentrations. The employed readout circuit operates at a wavelength of λ = 1550 nm with a laser power of 1 µW. The dimensions of the proposed biosensor are considered to be 365 × 340 × 2 μm³, making this sensor small enough and suitable for integration. The designed biosensor provides notable features of mechanical deflection sensitivities of 0.2053 nm/(ng/ml) and 7.2486 nm/nM, optical transmittance sensitivities of 0.535504 × 10−3 1/(ng/ml) and 18.91 × 10−3 1/nM, total output sensitivities of 0.5398 (mA/W)/(ng/ml) and 19.059 (mA/W)/nM, and measurement ranges of 0-1000 ng/ml and 0-28.33 nM for PSA and Hepatitis DNA, respectively. The proposed system is a sensitive and powerful sensor that can play an important role in diagnosing many diseases.