bluuebunny/crossref_metadata_2025_split huggingface dataset:
Security, Reliance and Availability: Psychometric features of the Kerns’ Security Scale in Hungarian population
Authors: Barcsi Beatrix , Hollódy Katalin , Péley Bernadette , Dorn Krisztina , Kerns Kathryn A. , Rózsa Sándor , Török Imre A. , Kállai János 
Published: May 2017

Background
This study examines the Kerns’ Security Scale (KSS) that is a self-report questionnaire to assess school-age children’s certain family-related experiences, and is widely used in the United States and in certain European countries.

Objectives
The aim of the present investigation is to review the factor structure of the KSS in Hungarian population and to describe the characteristics of the scales in an Eastern-Central European country, as well as to check its external validity by the Child Depression Inventory, and to evaluate its feasibility in clinical practice and school psychology services.

Methods
The sample consisted of 323 primary and secondary schools students (137 boys and 186 girls), aged 10–18 years. They completed the Kerns’ Security Scale and the Child Depression Inventory.

Results
statistical analysis has revealed that the items of the security questionnaire can be divided into three subscales, namely: Reliance, Availability, and Autonomy support. The mothers’ subscale scores are higher than fathers’ subscale scores (Reliance: t = 7.1, p < .001; Availability t = 8.9, p < .001; Autonomy support t = 3.2, p < .01).

Conclusion
The results supported the three factor model of the KSS, and recommended to apply for clinical practice and in school psychology services.
Health Care Resource Utilization and Associated Costs Among Metastatic Cutaneous Melanoma Patients Treated with Ipilimumab (INTUITION Study)
Authors: McArthur Grant A. , Mohr Peter , Ascierto Paolo Antonio , Arance Ana , Banos Hernaez Ana , Kaskel Peter , Weichenthal Michael , Shinde Reshma , Stevinson Kendall 
Published: May 2017

Abstract

Background
There are limited real-world data on health care resource utilization (HCRU) among advanced melanoma patients. The objective of this study was to describe HCRU and health care costs associated with the management of advanced melanoma patients receiving ipilimumab.

Methods
This retrospective multinational, observational study included advanced melanoma patients from Australia, Germany, Italy, and Spain who had received at least 1 dose of ipilimumab. Data extracted from medical charts included inpatient admissions, outpatient visits, surgical procedures, laboratory investigations, radiation therapy, imaging studies, and concomitant medications. Cost estimates were based on unit costs from country-specific standard reimbursement sources. Subgroup analyses were performed for BRAF mutation status and ipilimumab refractory patients, who had disease progression within 24 weeks of their last dose of ipilimumab.

Results
Mean age of 362 enrolled patients was 60.6 years (standard deviation [SD] 14.4). During a median follow-up period of 30.2 weeks, 57% of patients were admitted to hospital and 16% underwent surgery. Health care resource utilization rates varied substantially across countries and were highest in Germany. Concomitant medications to treat adverse events were commonly used. Subgroup analyses showed higher utilization rates among ipilimumab refractory and BRAF mutant patients. Mean weekly total costs associated with HCRU were lower in the pre-progression period (€107; 95% confidence interval (CI): 79–145) than in the post-progression period (€216; 95% CI: 180–259).

Conclusion
Health care resource utilization pattern and associated costs among patients treated with ipilimumab varied greatly among countries and between pre- and post-progression periods. There is a high economic burden associated with ipilimumab refractory melanoma.
Targeting BRAF-Mutant Non-Small Cell Lung Cancer: From Molecular Profiling to Rationally Designed Therapy
Authors: Baik Christina S. , Myall Nathaniel J. , Wakelee Heather A. 
Published: May 2017

Abstract
Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths globally. However, the identification of oncogenic driver alterations involved in the initiation and maintenance of NSCLC, such as epidermal growth factor receptor mutations and anaplastic lymphoma kinase translocation, has led to the development of novel therapies that directly target mutant proteins and associated signaling pathways, resulting in improved clinical outcomes. As sequencing techniques have improved, the molecular heterogeneity of NSCLC has become apparent, leading to the identification of a number of potentially actionable oncogenic driver mutations. Of these, one of the most promising therapeutic targets is B-Raf proto-oncogene, serine/threonine kinase (BRAF). Mutations in BRAF, observed in 2%–4% of NSCLCs, typically lead to constitutive activation of the protein and, as a consequence, lead to activation of the mitogen-activated protein kinase signaling pathway. Direct inhibition of mutant BRAF and/or the downstream mitogen-activated protein kinase kinase (MEK) has led to prolonged survival in patients with BRAF-mutant metastatic melanoma. This comprehensive review will discuss the clinical characteristics and prognostic implications of BRAF-mutant NSCLC, the clinical development of BRAF and MEK inhibitors from melanoma to NSCLC, and practical considerations for clinicians involving BRAF mutation screening and the choice of targeted therapy.
Male Breast Cancer as a Second Primary Cancer: Increased Risk Following Lymphoma
Authors: Farr Deborah E. , Thomas Alexandra , Khan Seema Ahsan , Schroeder Mary C. 
Published: May 2017

Abstract

Background
Male breast cancer (MBC) as a second primary cancer (SPC) has a known association with prior MBC. However, its association with non-breast index malignancies, relative to population risk, has not been previously reported.

Materials and Methods
Using Surveillance, Epidemiology, and End Results program (9 catchment area) data, we identified MBCs diagnosed from 1973–2012 as their SPC. Information regarding the index malignancy was also obtained. Standardized incidence ratios (SIR) of MBC as SPC were estimated, along with incidence rates and trends. Kaplan-Meier curves were used to estimate survival.

Results
Over a 38-year period, 464 MBCs were identified as SPC. The most common index malignancies were breast (SIR 30.86, 95% confidence interval [CI] 21.50–42.92, p &lt; .001), lymphoma (SIR 1.58, 95% CI 1.08–2.22, p = .014), melanoma (SIR 1.26, 95% CI 0.80–1.89), urinary (SIR 1.05, 95% CI 0.74–1.43), colorectal (SIR 0.94, 95% CI 0.69–1.24), and prostate (SIR 0.93 95% CI 0.81–1.07). Apart from the known association with prior breast cancer, the only significant association was with lymphoma as an index cancer, although not significant with a Bonferroni correction. From 1975–2012, incidence of breast cancer as a first cancer increased at an annual percentage change of 1.3% while breast cancer as a SPC increased at 4.7% (both p values &lt; .001).

Conclusion
Male breast cancer as a SPC has increased markedly over 4 decades. Men with a history of lymphoma may experience higher-than-expected rates of breast SPC. These observations warrant further research, and suggest possible etiologic connections with disease biology, prior therapy, or genetics.
Phase II Study of Modified Carboplatin Plus Weekly Nab-Paclitaxel in Elderly Patients with Non-Small Cell Lung Cancer: North Japan Lung Cancer Study Group Trial 1301
Authors: Miyauchi Eisaku , Inoue Akira , Usui Kazuhiro , Sugawara Shunichi , Maemondo Makoto , Saito Heisuke , Fujita Yuka , Kato Terufumi , Suzuki Toshiro , Harada Toshiyuki , Watanabe Hiroshi , Nakagawa Taku , Ichinose Masakazu 
Published: May 2017

Abstract

Lessons Learned
Weekly nanoparticle albumin-bound-paclitaxel (75 mg/m2) in combination with carboplatin (area under the curve 6 mg/mL/min) in elderly patients with previously untreated, advanced non-small cell lung cancer showed favorable efficacy, was well tolerated, and showed less neuropathic toxicity. This modified regimen offers potential for the treatment of elderly patients.

Background
The CA031 trial suggested weekly nanoparticle albumin-bound-paclitaxel (nab-PTX) was superior in efficacy to paclitaxel (PTX) once every 3 weeks when combined with carboplatin (CBDCA) for advanced non-small cell lung cancer (NSCLC) patients; a subgroup analysis of elderly patients looked promising. In a multicenter phase II trial, we prospectively evaluated the efficacy and tolerability of modified CBDCA plus weekly nab-PTX for elderly patients with untreated advanced NSCLC.

Methods
Eligible patients received CBDCA (area under the curve [AUC] 6 mg/mL/min) on day 1 and nab-PTX (75 mg/m2) on days 1, 8, and 15 every 4 weeks. The primary endpoint was an overall response rate (ORR), and secondary endpoints were progression-free survival (PFS), overall survival (OS), and toxicity.

Results
Of 32 patients (median age of 78 years), 84% were male, 56% had stage IV NSCLC, and 56% had squamous cell carcinoma. ORR and disease control rates were 50% (95% confidence interval (CI): 33–67) and 94% (95% CI: 85–100), respectively. Median PFS and OS were 6.4 months (95% CI: 4.8–8.0) and 17.5 months (95% CI: 11.9–23.1), respectively. Grade ≥3 toxicities were neutropenia (47%), leukopenia (38%), anemia (34%), thrombocytopenia (25%), and anorexia (9%). Febrile neutropenia and treatment-related deaths were not observed.

Conclusion
Modified CBDCA plus weekly nab-PTX demonstrated significant efficacy and acceptable toxicities in elderly patients with advanced NSCLC.
DEVELOPMENT OF PROFESSIONAL-PEDAGOGICAL MOTIVATION OF FUTURE TEACHERS IN THE CONDITIONS OF THE INTEGRATED EDUCATIONAL AND PROFESSIONAL SPACE
Authors: Chekina Alena , Vilchynskaya Liudmila 
Published: May 2017

The article is devoted to consideration of a problem of modernization of vocational training of future teachers by strengthening of its practical orientation. One of solutions of this problem is designing of the new educational space based on close interaction and integration of resources of university and organizations-customers of specialists. In article the author's model of the integrated educational-professional space of training of teachers is characterized. This model including a number of the interconnected components: target, structural, resource, substantial, procedural-activity and productive. The professional-pedagogical motivation at future teachers was studied by means of "Self-assessment of Professional-Pedagogical Motivation" by N. P. Fetiskin. This tool allows to define at what step of a motivational ladder there is a student: from indifference to future profession to the professional need to seize bases of pedagogical skill.
THE RELATIONSHIP BETWEEN AEROBIC LOAD AND PERSONALITY TRAITS IN SENIORS WITH DIFFERENT LEVEL OF AEROBIC PHYSICAL ACTIVITY EXPERIENCE
Authors: Ulmane Zane , Harlamova Jeļena , Arnis Voldemārs , Šneidere Kristīne , Stepens Ainārs 
Published: May 2017

Introduction Personality traits are stable and create an individuals’ behavior as well as allows to predict what kind of exercise type, intensity and frequency they might choose (Allen, Greenlees, & Jones, 2011). Involvement in physical activity can predict the dimension of such personality traits as extroversion and consciousness (Gallagher, Yancy, Denissen, Kühnel, & Voils, 2013). Research indicates that aerobic excercise promotes a healthy aging process as aerobic activity improves heart and respiratory system, by increasing the oxygen circulation as well as the heart and respiratory rate (WHO, 2009). The main objective of this study was to explore personality traits associate with long-term aerobic physical activity in seniors. Methods Participants were 26 adults, aged from 65 to 80 years (M = 72,65, SD = 4,8). The participants were divided into three groups based on the level of aerobic physical activity in their daily lives. In the first group we included seniors with regular long-term aerobic physical activity experience, in the second group we included seniors with short-term regular aerobic physical activity experience and in the third group we included seniors that do not engage in aerobic physical activity. The data were obtained with four questionnaires – „Latvian Personality questionnaire”(LPA-v3, Perepjolkina, Reņģe, 2013),a modified version of „Social Determinants of Health Behaviours” (FINBALT, 2014), „The International Physical Activity Questionnaire – modification for elderly „ (Hurting-Wennolof, Hagstromer, & Olsson, 2010) and Demographic Data questionnaire ( age, sex, native language). Participation in the study was voluntary and all patients signed Informed Consent Form before participating in the study. Results: Between the three groups significant differences in neurotism scale were observed (F = 4,624, P < 0,05). There were no significant correlations across all groups and the six personality dimensions. Conclusions: One of the main limitations of the study is the lunequal distribution of groups basd on gender. Another and possibly more significant limitation is the lack of more regular and vingorous exercise in the group with long-term aerobic physical activity experience, witch is higher in some of the participants with short-term experience. This creates a challlenge in creating objective physical activity groups.
TECHNOFERENCE, COUPLE’S RELATIONSHIP SATISFACTION CORRELATION BETWEEN CONFLICT MANAGEMENT STRATEGIES CHOICE
Authors: Dudkina Aija , Maslinovska Lida 
Published: May 2017

The aim of this scientific research article is to describe the satisfaction with pairs’ relationship and conflict management strategies choice correlation between technoference. Pairs’ relationship, their formation and long-term existence is influenced by different factors, however, important to prescribe their existence is both partners' satisfaction with them. Quality of the relationship depends on overall life satisfaction. Studies on satisfaction with the pairs relations have a tendency to grow, as evidenced by the number of research databases. For example, in 2015 the database APAPsychNet they are 32 studies, but by June 2016 already 20 studies of the relationship, which are studied more new aspects that are not so far been adequately studied. Studies have been conducted on the use of technology devices impact on pairs’ relationships satisfaction with the relationship (for example, Sidelinger, Avash,et.al., 2008, Coyne, et.al., 2011). Available sources is a study that analyzes satisfaction with the pairs’ relationships correlation with technoference (technical devices in use caused by disruption in the pairs mutual communication), which leads to the conclusion that in this perspective the topic has not yet been adequately studied (Coyne McDaniel, 2016). This study will be determined not only technoference correlation with the satisfaction of pairs relationship and conflict management strategies choice of partners, but will also explore what device causing the most disruption and whether there is technoference correlation with conflict management strategies.
8-9 YEAR OLD CHILDREN EMPATHY AND EMOTIONAL REGULATION MEASURMENT CHANGES IN NON - VIOLENT COMMUNICATION INTERVENCE PROGRAM BY M. ROSENBERG
Authors: Ozola Laura , Plaude Alla 
Published: May 2017

The aim of this paper is to investigate the 2nd grade children empathy and emotional regulation differences, after non – violent communication intervence program. Non- violent communication intervence program is based on M.Rosenberg,(2003) four step model. Nowdays a lot of schools and teachers, have a huge problem to deal with children challenging behaviour, like antisocial and impulsive,, bulling, verbal, non verbal agression, conflicts and the latest researches have shown, that it is strictly connected with social – emotional competence problems. First of all, emotional regulation influences peer relationship quality and life’s well being and success maintenance (Lane, 2000). Although, empathy is one of the most essential social competences components and has a strong connection between ourselves and others and is the biggest motivator of prosocial behaviour (de Waal, 2008). Zin & Elias state, that practicing different intervence programms based on social, emotional and mindfulness exercises with the focus on thoughts, feelings, meditation is the direct way to enlarge empathy and emotional regulation (Zin & Elias,2007).
Underweight increases the risk of pulmonary tuberculosis in adult
Authors: Irawan Galuh Chandra , Margawati Ani , Rosidi Ali 
Published: May 2017

<p>Background<br />Tuberculosis (TB) is a leading cause of morbidity and mortality, especially in middle- and low-income countries. The risk of developing TB may be related to nutritional status. Socioeconomic and behavioral factors are also shown to increase the susceptibility to TB infection. The objective of this study was to determine nutritional factors as risk factors of pulmonary TB in adult.</p><p>Methods<br />This was an observational study of case control design. The study subjects were community members consisting of 19 adult cases of pulmonary tuberculosis and 38 controls. Data on nutritional intakes were obtained by semiquantitative food frequency questionnaire (FFQ), while smoking behavior, history of DM, body mass index, education, and income were obtained by structured interviews. The data were analyzed by independent t-test and logistic regression for calculation of the odds ratio (OR).</p><p>Results<br />The bivariate test showed that the adequacy levels for energy (OR=6.8; 95% CI: 1.51-30.54), protein (OR=5.1; 95% CI: 1.52-17.14), vitamin A (OR=4.2; 5% CI: 1.31-13.54), vitamin C (OR=3.8;95% CI: 1.21-12.36), selenium (OR=4.2; 95% CI: 1.34-13.58), body mass index (OR=4.4; 95% CI: 1.32-14.35) and smoking behavior (OR=3.7; 95% CI: 1.15-11.9), were significant risk factors for pulmonary tuberculosis. Multiple logistic regression test showed that low body mass index (&lt;18.5 kg/m2) (OR=6.0; 95% CI: 1.32-27.18) was a the most influential risk factor of pulmonary tuberculosis.</p><p>Conclusion<br />Low body mass index is the most influential risk factor for pulmonary tuberculosis incidence in adult. Nutrition profile in adult is an important determinant of TB incidence.</p>
A prospective study of feasibility and short term outcome of stoma reversal under local anaesthesia
Authors: Kumar Ashok , Kumar Yogesh , Singh Vineet , Kumar Arvind 
Published: May 2017

Background: Stoma fashioning (ileostomy and colostomy) are very important and established procedures for deviation of bowel contents to procure the distal anostomosis. It is a very common procedure in cases of bowel obstruction, perforation, inflammatory bowel disease and large bowel disorders like Ca colon and Ca rectum, colonic fistulas, trauma to colon and rectum. Stoma reversal is a routine procedure but is usually performed using general or regional anaesthesia but large number of patient list for stoma reversal under general or regional anaesthesia, led to unnecessary delay in stoma reversal due to paucity of anaesthesia. Local anaesthesia has thus proved useful to handle a large load of stoma reversal, so we investigated feasibility of performing stoma reversal using local anaesthetic agent.Methods: Total 54 patients underwent for stoma reversal under local anaesthesia, admitted to Department of General Surgery, Nehru Hospital, B. R. D. Medical College, Gorakhpur, Uttar Pradesh, India.Results: Reversal of stoma could be comfortably done under safe dose of local anaesthesia, most of the patients remain comfortable intraoperatively, 4 out of 54 patients had systemic complications like vomiting and bradycardia and 2 had associated bowel injury. only 2 patients had minor anostomotic leak and 1 had developed fecal fistula while rest had normal intact anostomosis. Only 2 patients had reported moderate pain and 1 had mild pain according to visual analog scale and in 42 out of 54 patients had normal wound healing while 5 had minor erythema, 6 had seroma formation and 1 had complain of pus discharge.Conclusions: Reversal of STOMA can be performed safely and comfortably under local anaesthesia. Post op short term outcome and complications are comparable to that done under general or regional anaesthesia.
Fitossociologia de plantas espontâneas sob cultivo agroecológico na bananeira no Sertão Paraibano
Authors: Rodrigues Marilia Hortência Batista Silva , Andrade Francisco Edu de , Nascimento Danielle Maria do , Hafle Oscar Mariano , Pereira Junior Ednaldo Barbosa 
Published: May 2017

<p>Plantas são organismos sésseis e, portanto, refletem as condições locais. Elas apresentam geralmente maiores níveis de plasticidade fenotípica comparado aos animais, o que significa que efeitos de diversos estressores podem ser mais aparentes e, potencialmente, mais fáceis de serem medidos e quantificados. Este trabalho objetivou realizar um levantamento fitossociológico das espécies de plantas espontâneas presentes no cultivo de diferentes genótipos de banana sob manejo agroecológico no Alto Sertão Paraibano. Foi realizado em uma área experimental de 1.512m<sup>2</sup>. O espaçamento entre plantas foi de 3x3 m. Para a identificação e quantificação de plantas espontâneas, foi utilizado o método do quadrado inventário. Foram calculados: frequência, frequência relativa, densidade, densidade relativa, abundância, abundância relativa e o índice de importância relativa. Foram identificadas um total de 93 indivíduos correspondentes a 21 espécies, distribuídas em 11 famílias. A área em estudo apresentou uma grande diversidade de plantas espontâneas no cultivo da banana, sendo a mais frequente (18,18%) e com maior densidade relativa (38,70%) a espécie <em>Cyperus rotundus, s</em>eguido da <em>Alternanthera tenella </em>com frequência relativa de 13,63% e densidade relativa de 15,05%.</p><p class="Default" align="center"><strong><em>Phytosociology of spontaneous plants under agroecological cultivation in the banana tree in </em></strong><strong><em>backlands of </em></strong><strong><em>Paraiba</em></strong><strong></strong></p><p align="center"><strong><em> </em></strong></p><p><strong>Abstract</strong><strong>: </strong>Plants are sessile organisms and therefore reflect local conditions. They generally have higher levels of phenotypic plasticity compared to animals, which means that the effects of various stressors may be more apparent and potentially easier to measure and quantify. This work aimed to perform a phytosociological survey of the species of spontaneous plants present in the cultivation of different banana genotypes under agroecological management in Hinterland Paraibano. It was carried out in an experimental area of 1,512m<sup>2</sup>. The spacing between plants was 3x3 m. For the identification and quantification of spontaneous plants, the square inventory method was used. Frequency, relative frequency, density, relative density, abundance, relative abundance and relative importance index were calculated. A total of 93 individuals corresponding to 21 species were identified, distributed in 11 families. The area under study presented a great diversity of spontaneous plants in banana cultivation, being the most frequent (18.18%) and with greater relative density (38.70%) the species Cyperus rotundus, followed by Alternanthera tenella with relative frequency of 13.63% and relative density of 15.05%.</p><p><strong> </strong></p>