bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of oncolytic virotherapy for the treatment of oral cancer – At the waiting stage for clinical use
Authors: Yura Yoshiaki , Hamada Masakazu 
Published: December 2016

AbstractOncolytic virotherapy originated from the finding that virus‐infected tumor cells are destroyed by the cytopathic effects of viruses. Cell death induced by viral infections in tumor tissues also promotes inherent tumor immunity in cancer patients. Several DNA and RNA viruses have been proposed as candidates for this treatment through in vitro and in vivo studies as well as clinical trials. Oral cancer is often accompanied by lymph node metastasis, resulting in worse patient prognoses. Some oncolytic viruses have been investigated for their therapeutic effects on patients with advanced head and neck cancer, including oral cancer. Oncolytic virotherapy is expected to become a treatment modality that will be essential for controlling chemoradio‐resistant oral cancer.
ON THE STRUCTURE OF GRAPHS WHICH ARE LOCALLY INDISTINGUISHABLE FROM A LATTICE
Authors: BENJAMINI ITAI , ELLIS DAVID 
Published: December 2016

For each integer $d\geqslant 3$, we obtain a characterization of all graphs in which the ball of radius $3$ around each vertex is isomorphic to the ball of radius 3 in $\mathbb{L}^{d}$, the graph of the $d$-dimensional integer lattice. The finite, connected graphs with this property have a highly rigid, ‘global’ algebraic structure; they can be viewed as quotient lattices of $\mathbb{L}^{d}$ in various compact $d$-dimensional orbifolds which arise from crystallographic groups. We give examples showing that ‘radius 3’ cannot be replaced by ‘radius 2’, and that ‘orbifold’ cannot be replaced by ‘manifold’. In the $d=2$ case, our methods yield new proofs of structure theorems of Thomassen [‘Tilings of the Torus and Klein bottle and vertex-transitive graphs on a fixed surface’, Trans. Amer. Math. Soc.323 (1991), 605–635] and of Márquez et al. [‘Locally grid graphs: classification and Tutte uniqueness’, Discrete Math.266 (2003), 327–352], and also yield short, ‘algebraic’ restatements of these theorems. Our proofs use a mixture of techniques and results from combinatorics, geometry and group theory.
Uptake and Beliefs Regarding Seasonal Influenza Vaccination Among Childcare Center Staff, Administrators, and Parents
Authors: Rebmann Terri , Loux Travis M. , Daly Brendan 
Published: December 2016

Surveys were distributed to parents and childcare agency staff to determine seasonal influenza vaccine uptake. Multivariate logistic regressions identified vaccination determinants. Overall, 351 parents and staff participated (response rate, 32%). One-half (168 [48%]) received vaccine. Vaccination predictors included healthcare provider or employer recommendation, perceived seriousness, and no vaccine fear.Infect Control Hosp Epidemiol 2017;38:367–370
Comparing Catheter-Associated Urinary Tract Infection Prevention Programs Between Veterans Affairs Nursing Homes and Non–Veterans Affairs Nursing Homes
Authors: Mody Lona , Greene M. Todd , Saint Sanjay , Meddings Jennifer , Trautner Barbara W. , Wald Heidi L. , Crnich Christopher , Banaszak-Holl Jane , McNamara Sara E. , King Beth J. , Hogikyan Robert , Edson Barbara S. , Krein Sarah L. 
Published: December 2016

OBJECTIVEThe impact of healthcare system integration on infection prevention programs is unknown. Using catheter-associated urinary tract infection (CAUTI) prevention as an example, we hypothesize that US Department of Veterans Affairs (VA) nursing homes have a more robust infection prevention infrastructure due to integration and centralization compared with non–VA nursing homes.SETTINGVA and non-VA nursing homes participating in the AHRQ Safety Program for Long-Term Care collaborative.METHODSNursing homes provided baseline information about their infection prevention programs to assess strengths and gaps related to CAUTI prevention via a needs assessment questionnaire.RESULTSA total of 353 of 494 nursing homes from 41 states (71%; 47 VA and 306 non-VA facilities) responded. VA nursing homes reported more hours per week devoted to infection prevention-related activities (31 vs 12 hours; P<.001) and were more likely to have committees that reviewed healthcare-associated infections. Compared with non-VA facilities, a higher percentage of VA nursing homes reported tracking CAUTI rates (94% vs 66%; P<.001), sharing CAUTI data with leadership (94% vs 70%; P=.014) and with nursing personnel (85% vs 56%, P=.003). However, fewer VA nursing homes reported having policies for appropriate catheter use (64% vs 81%; P=.004) and catheter insertion (83% vs 94%; P=.004).CONCLUSIONSAmong nursing homes participating in an AHRQ-funded collaborative, VA and non-VA nursing homes differed in their approach to CAUTI prevention. Best practices from both settings should be applied universally to create an optimal infection prevention program within emerging integrated healthcare systems.Infect Control Hosp Epidemiol 2017;38:287–293
Effective Antibiotic Conservation by Emergency Antimicrobial Stewardship During a Drug Shortage
Authors: Hsueh Kevin , Reyes Maria , Krekel Tamara , Casabar Ed , Ritchie David J. , Jafarzadeh S. Reza , Hays Amanda J. , Lane Michael A. , Durkin Michael J. 
Published: December 2016

We present the first description of an antimicrobial stewardship program (ASP) used to successfully manage a multi-antimicrobial drug shortage. Without resorting to formulary restriction, meropenem utilization decreased by 69% and piperacillin-tazobactam by 73%. During the shortage period, hospital mortality decreased (P=.03), while hospital length of stay remained unchanged.Infect Control Hosp Epidemiol 2017;38:356–359
Earliest occurrence of lophogastrid mysidacean arthropods (Crustacea, Eucopiidae) from the Anisian Luoping Biota, Yunnan Province, China
Authors: Feldmann Rodney M. , Schweitzer Carrie E. , Hu Shixue , Huang Jinyuan , Zhou Changyong , Zhang Qiyue , Wen Wen , Xie Tao , Schram Frederick R. , Jones Wade T. 
Published: December 2016

AbstractTiny, pelagic arthropods from the Anisian Luoping Biota exposed in two quarries near Luoping, Yunnan Province, China, represent the numerically most abundant organisms in the assemblage. They form the basis for definition of two, and possibly three, species referred to the order Lophogastrida, family Eucopiidae.Yunnanocopia grandisnew genus new species andY.longicaudan. gen. new species represent the oldest occurrence of mysidaceans in the fossil record. Their anatomy allies them with the Ladinian speciesSchimperella acanthocercusTaylor, Schram, and Shen, 2001, from Guizhou Province, China, which previously was thought to be the oldest lophogastrid, and with extant species of Eucopiidae. Their appearance in the Anisian represents one additional element of the early faunal radiation within the Luoping Biota following the end-Permian extinction event. Presence of well-preserved oostegites, along with other morphological features, documents a conservative bauplan expressed in Eucopiidae.
Incidental findings on magnetic resonance imaging of the internal auditory meatus performed to investigate audiovestibular symptoms
Authors: Htun H M , Mui S L , Williams C , Hans P S 
Published: December 2016

AbstractObjective:To determine the frequency of incidental findings found on magnetic resonance imaging scans of the internal auditory meatus performed to investigate audiovestibular symptoms, and to determine how to best manage these when found.Method:A retrospective review was conducted of internal auditory meatus magnetic resonance imaging scans during a three-month period in the radiology department at a UK district general hospital.Results:A total of 109 scans were reviewed. Of these, 92.7 per cent showed no retrocochlear pathology, 0.9 per cent showed vestibular schwannoma, 6.4 per cent revealed vascular loops, and 2.8 per cent showed incidental findings that warranted further action and investigation. Of the scans, 40.4 per cent showed other incidental pathologies such as age-related ischaemic changes, and sinus disease that required no further intervention. Of the magnetic resonance imaging scans reviewed, 49.5 per cent were entirely normal.Conclusion:Almost half of the scans investigating audiovestibular symptoms showed incidental findings. Otolaryngologists should have an understanding of the significance of the most commonly encountered incidental findings, and should counsel patients appropriately and refer them onward when necessary.
Effectiveness of transperforation myringoplasty in bilateral chronic otitis media patients undergoing contralateral tympanoplasty
Authors: Ihsan A T , Ranjana K 
Published: December 2016

AbstractObjectives:Bilateral tympanic membrane perforation closure is usually performed by otosurgeons in two sittings. However, in this study, transperforation myringoplasty was performed alongside contralateral tympanoplasty in a single sitting. The effectiveness of transperforation myringoplasty procedure and the benefits of single sitting bilateral surgery were evaluated.Methods:A prospective study of 50 selected patients with mucosal-type bilateral chronic otitis media was conducted. All patients underwent transperforation myringoplasty on the side that met the inclusion criteria and tympanoplasty on the contralateral side. Graft uptake and hearing improvement were evaluated after 6 months.Results:At the 6-month follow up, the graft uptake rate was 82 per cent, the hearing gain was 11.5 dB and the air–bone gap gain was 11.6 dB.Conclusion:This procedure offers perforation closure in a single sitting to patients with bilateral chronic otitis media who meet the inclusion criteria.
Prognostic factors for idiopathic sudden sensorineural hearing loss treated with hyperbaric oxygen therapy and intravenous steroids
Authors: Hosokawa S , Sugiyama K , Takahashi G , Takebayashi S , Mineta H 
Published: December 2016

AbstractObjective:This study evaluated the prognosis of idiopathic sudden sensorineural hearing loss when treated with hyperbaric oxygen therapy and intravenous steroids.Methods:The clinical data for 334 patients with idiopathic sudden sensorineural hearing loss treated by hyperbaric oxygen therapy and intravenous steroids at our hospital were retrospectively reviewed. These data included the initial averaged five-frequency hearing level, patient age, interval between onset of symptoms and treatment, vertigo as a complication, and co-existence of diabetes mellitus.Results:The overall improvement rate was 69.2 per cent, including better improvement (25.5 per cent), good improvement (21.0 per cent) and fair improvement (22.7 per cent).Conclusion:Hyperbaric oxygen therapy appears to confer a significant additional therapeutic benefit when used in combination with steroid therapy for idiopathic sudden sensorineural hearing loss. If performed early, hyperbaric oxygen therapy may bring about hearing improvement in many patients who are unresponsive to initial therapy.
Racial disparities in papillary thyroid microcarcinoma survival
Authors: Megwalu U C , Saini A T 
Published: December 2016

AbstractObjective:To evaluate the impact of race on survival in patients with papillary thyroid microcarcinoma.Methods:The study cohort included 17 668 patients diagnosed with papillary thyroid microcarcinoma between 1988 and 2009, identified in the Surveillance, Epidemiology, and End Results 18 database of the National Cancer Institute.Results:Black patients had lower overall survival than other racial groups (p < 0.001). Black patients had significantly worse overall survival (hazard ratio = 2.59) after adjusting for sex, marital status, age, year of diagnosis, multifocal disease and type of surgery. A subset analysis of Black patients revealed no significant difference in overall survival for total thyroidectomy versus lobectomy (p = 0.15).Conclusion:Black race is a negative prognostic factor in thyroid cancer, which cannot be explained by advanced disease stage. Further research on mechanisms by which race affects survival is needed to reveal areas of opportunity for interventions aimed at reducing health disparities in cancer care.
“Bypass the Lying Mouths”: How Does the CCP Tackle Information Distortion at Local Levels?
Authors: Gao Jie 
Published: December 2016

AbstractThe deliberate distortion of the work accomplishments of local governments is a growing concern for China's leaders in the reform era. How do they tackle this problem and gather reliable data? This study argues that the CCP has developed bypassing strategies to remedy the deficiencies of the statistical system which is vulnerable to artificial data distortion. By employing these strategies, authorities requiring authentic information can directly access the raw data, thereby bypassing lower-level officials who have incentives to distort performance information in the level-by-level reporting process. This study shows that the adoption of bypassing strategies enhances the capacity of the party-state to gather local intelligence. Although the strategies are limited in their ability to ensure the quality of certain types of data, their use should improve the quality of key information on the performance of local governments in the long term.
Changes in Physical Activity and Function with Transition to Retirement Living: A Pilot Study
Authors: Regan Kayla , Intzandt Brittany , Swatridge Karli , Myers Anita , Roy Eric , Middleton Laura E. 
Published: December 2016

RÉSUMÉCette étude pilote a examiné les changements dans l’activité physique et la fonction chez les personnes âgées se déplaçant de logements communautaires aux maisons de retraite. L’activité physique a été évaluée en utilisant un Actigraph (GT3X +) moniteur d’activité; l’activité physique par type a été rapportée avec le questionnaire CHAMPS de l’activité. La fonction physique a été évaluée en utilisant le Test de Fitness Senior. L’activité physique totale, objectivement contrôlée, a diminué après la transition (p = 0,02). Rapports d’activité physique par type ont indiqué que seules les activités de la vie quotidienne ont diminué (p <0,01), bien que l’exercice intentionnel s’est augmenté (p <0,03) avec la transition. L’endurance et la force sont également améliorés (p <0,05 et p <0,04). Résultats du projet pilote indiquent que des avantages physiques possibles profitent de la vie de la retraite, bien que les efforts visant à réduire le temps sédentaire sont nécessaires.
Organic strawberry in Mediterranean greenhouse: Effect of different production systems on soil fertility and fruit quality
Authors: Tittarelli F. , Ceglie F.G. , Ciaccia C. , Mimiola G. , Amodio M.L. , Colelli G. 
Published: December 2016

AbstractIn Europe, the lack of specific rules regulating organic vegetable production in protected conditions has led to the implementation of extremely diversified systems of production, at different level of intensification. In this study, we compared three strawberry organic production systems based on the following main criteria of soil fertility management: input substitution (SB), a simplified system of organic production that mimics conventional agricultural practices and two systems characterized by a more complex soil fertility management, based on the introduction, in the rotation of agroecological service crops (ASCs) and compost (AC), and of ASCs and cattle manure (AM). Strawberry yields, in the compared systems, were not significantly different in both years of our research, while, as a whole, the yield in 2013 (30.3 Mg ha−1) was significantly higher than in 2014 (28.9 Mg ha−1). Crop nitrogen (N) needs, during the entire cycle of production, were satisfied according to the same pattern by SB, AC and AM, while green manuring and organic amendments in AM and AC determined a higher soil organic N content, compared with SB. As far as the production quality is concerned, both AM and AC treatments yielded strawberry fruits similar to SB, but with better characteristics in terms of color and phenolic content. AM and AC did not differentiate statistically in the two year period of our research.
Mitochondrial permeability transition pore induction is linked to formation of the complex of ATPase C-subunit, polyhydroxybutyrate and inorganic polyphosphate
Authors: Elustondo P A , Nichols M , Negoda A , Thirumaran A , Zakharian E , Robertson G S , Pavlov E V 
Published: December 2016

AbstractMitochondrial permeability transition pore (mPTP) opening allows free movement of ions and small molecules leading to mitochondrial membrane depolarization and ATP depletion that triggers cell death. A multi-protein complex of the mitochondrial ATP synthase has an essential role in mPTP. However, the molecular identity of the central 'pore' part of mPTP complex is not known. A highly purified fraction of mammalian mitochondria containing C-subunit of ATPase (C-subunit), calcium, inorganic polyphosphate (polyP) and polyhydroxybutyrate (PHB) forms ion channels with properties that resemble the native mPTP. We demonstrate here that amount of this channel-forming complex dramatically increases in intact mitochondria during mPTP activation. This increase is inhibited by both Cyclosporine A, an inhibitor of mPTP and Ruthenium Red, an inhibitor of the Mitochondrial Calcium Uniporter. Similar increases in the amount of complex formation occurs in areas of mouse brain damaged by ischemia-reperfusion injury. These findings suggest that calcium-induced mPTP is associated with de novo assembly of a channel comprising C-subunit, polyP and PHB.
Questions and controversies: the role of necroptosis in liver disease
Authors: Dara Lily , Liu Zhang-Xu , Kaplowitz Neil 
Published: December 2016

AbstractAcute and chronic liver injury results in hepatocyte death and turnover. If injury becomes chronic, the continuous cell death and turnover leads to chronic inflammation, fibrosis and ultimately cirrhosis and hepatocellular carcinoma. Controlling liver cell death both in acute injury, to rescue the liver from acute liver failure, and in chronic injury, to curb secondary inflammation and fibrosis, is of paramount importance as a therapeutic strategy. Both apoptosis and necrosis occur in the liver, but the occurrence of necroptosis in the liver and its contribution to liver disease is controversial. Necroptosis is a form of regulated necrosis which occurs in certain cell types when caspases (+/−cIAPs) are inhibited through the RIPK1-RIPK3 activation of MLKL. The occurrence of necroptosis in the liver has recently been examined in multiple liver injury models with conflicting results. The aim of this review is to summarize the published data with an emphasis on the controversies and remaining questions in the field.
Interatomic Coulombic decay cascades in multiply excited neon clusters
Authors: Nagaya K. , Iablonskyi D. , Golubev N. V. , Matsunami K. , Fukuzawa H. , Motomura K. , Nishiyama T. , Sakai T. , Tachibana T. , Mondal S. , Wada S. , Prince K. C. , Callegari C. , Miron C. , Saito N. , Yabashi M. , Demekhin Ph. V. , Cederbaum L. S. , Kuleff A. I. , Yao M. , Ueda K. 
Published: December 2016

AbstractIn high-intensity laser light, matter can be ionized by direct multiphoton absorption even at photon energies below the ionization threshold. However on tuning the laser to the lowest resonant transition, the system becomes multiply excited, and more efficient, indirect ionization pathways become operative. These mechanisms are known as interatomic Coulombic decay (ICD), where one of the species de-excites to its ground state, transferring its energy to ionize another excited species. Here we show that on tuning to a higher resonant transition, a previously unknown type of interatomic Coulombic decay, intra-Rydberg ICD occurs. In it, de-excitation of an atom to a close-lying Rydberg state leads to electron emission from another neighbouring Rydberg atom. Moreover, systems multiply excited to higher Rydberg states will decay by a cascade of such processes, producing even more ions. The intra-Rydberg ICD and cascades are expected to be ubiquitous in weakly-bound systems exposed to high-intensity resonant radiation.
Discovery of a new type of topological Weyl fermion semimetal state in MoxW1−xTe2
Authors: Belopolski Ilya , Sanchez Daniel S. , Ishida Yukiaki , Pan Xingchen , Yu Peng , Xu Su-Yang , Chang Guoqing , Chang Tay-Rong , Zheng Hao , Alidoust Nasser , Bian Guang , Neupane Madhab , Huang Shin-Ming , Lee Chi-Cheng , Song You , Bu Haijun , Wang Guanghou , Li Shisheng , Eda Goki , Jeng Horng-Tay , Kondo Takeshi , Lin Hsin , Liu Zheng , Song Fengqi , Shin Shik , Hasan M. Zahid 
Published: December 2016

AbstractThe recent discovery of a Weyl semimetal in TaAs offers the first Weyl fermion observed in nature and dramatically broadens the classification of topological phases. However, in TaAs it has proven challenging to study the rich transport phenomena arising from emergent Weyl fermions. The series MoxW1−xTe2 are inversion-breaking, layered, tunable semimetals already under study as a promising platform for new electronics and recently proposed to host Type II, or strongly Lorentz-violating, Weyl fermions. Here we report the discovery of a Weyl semimetal in MoxW1−xTe2 at x=25%. We use pump-probe angle-resolved photoemission spectroscopy (pump-probe ARPES) to directly observe a topological Fermi arc above the Fermi level, demonstrating a Weyl semimetal. The excellent agreement with calculation suggests that MoxW1−xTe2 is a Type II Weyl semimetal. We also find that certain Weyl points are at the Fermi level, making MoxW1−xTe2 a promising platform for transport and optics experiments on Weyl semimetals.
SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer
Authors: Bon Emeline , Driffort Virginie , Gradek Frédéric , Martinez-Caceres Carlos , Anchelin Monique , Pelegrin Pablo , Cayuela Maria-Luisa , Marionneau-Lambot Séverine , Oullier Thibauld , Guibon Roseline , Fromont Gaëlle , Gutierrez-Pajares Jorge L. , Domingo Isabelle , Piver Eric , Moreau Alain , Burlaud-Gaillard Julien , Frank Philippe G. , Chevalier Stéphan , Besson Pierre , Roger Sébastien 
Published: December 2016

AbstractThe development of metastases largely relies on the capacity of cancer cells to invade extracellular matrices (ECM) using two invasion modes termed ‘mesenchymal’ and ‘amoeboid’, with possible transitions between these modes. Here we show that the SCN4B gene, encoding for the β4 protein, initially characterized as an auxiliary subunit of voltage-gated sodium channels (NaV) in excitable tissues, is expressed in normal epithelial cells and that reduced β4 protein levels in breast cancer biopsies correlate with high-grade primary and metastatic tumours. In cancer cells, reducing β4 expression increases RhoA activity, potentiates cell migration and invasiveness, primary tumour growth and metastatic spreading, by promoting the acquisition of an amoeboid–mesenchymal hybrid phenotype. This hyperactivated migration is independent of NaV and is prevented by overexpression of the intracellular C-terminus of β4. Conversely, SCN4B overexpression reduces cancer cell invasiveness and tumour progression, indicating that SCN4B/β4 represents a metastasis-suppressor gene.