bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stevia By-product Fraction has Antioxidant Capacity and has been Evaluated for its Antihyperglycemic and Antilipid Potential
Authors: Letícia Serra Cabeça Cynthia , Campangolli Pereira Betânea , Caroline Nogueira Natani , Leonardo Marotti Siciliano Paulo , Rosa Trentin Zorzenon Maria , Sergio Dacome Antonio , Kazue Enokida Milena , de Oliveira Souza Felipe , Godoi Silva Pauline , Rodrigues de de Oliveira Adan , Jorge Pilau Eduardo , Claudio da Costa Silvio , Gimenez Milani Fernandes Paula 
Published: October 2024

Introduction/Objective:
The ethanolic pretreatment of stevia leaves is considered ecologically
favorable and increases its yield, purity level, and sensory profile of sweeteners. We
investigated the by-product generated so that we can provide a viable and applicable destination
to effectively contribute to the production and industrial chain of stevia sweeteners. Recently, an
antioxidant and antidiabetic fraction was obtained through stevia methanolic extraction. However,
this process is costly, has a low yield, and is non-green. In this study, we got an antioxidant
fraction of stevia from its pretreatment by-product, the ethanolic extract, characterized its bioactive
compounds – mainly phenolic acids and flavonoids – and evaluated its antidiabetic and antilipid
capacity.

Methods:
The ethanolic extract was fractionated, then the ethyl acetate fraction was microencapsulated.
Physicochemical, Mass Spectrometry (UHPLC/MS-MS), scanning electron microscopy,
microencapsulation efficiency, and antioxidant capacity analyses were carried out. The antioxidant
capacity was evaluated. Antihyperglycemic capacity was assessed by inhibition
of α-glucosidase and α-amylase. For antilipid potential, inhibition of pancreatic lipase was
measured.

Results:
Antioxidant potential was observed mainly in the fraction. Microencapsulation improved
the stability of the fraction. Mass spectrometry allowed comparison with phenolic and flavonoid
compounds from the methanolic and ethanolic fractions of the by-product. Many compounds
were coincident, which may explain the similar antioxidant capacity found. The samples showed
more than 90% inhibition of alpha-glucosidase, which may indicate potential antidiabetic activity.
All samples showed inhibition of the pancreatic lipase enzyme higher than 80%, reaching 91.05%
for the free fraction.

Conclusion:
This study represented the recovery of a by-product and showed that this antioxidant
fraction deserves further investigation for its bioactive potential, especially antioxidant, antidiabetic,
and anti-lipid.
A Comprehensive Review on Role of Natural Polymers in Gastro Retentive Drug Delivery System (GRDDS)
Authors: Singh Manisha , Das Manas Kumar 
Published: October 2024

Abstract:
This review is to present a general outline of potent & promising natural polymers (on
which only slight research is done) along with their attributes & their pharmaceutical functions in
the development of GRDDS (gastro retentive drug delivery system). Therefore, there is a need of
more attention & focus on some of these natural polymers which are playing a crucial & indispensable
role in the fabrication of GRDDS. Recent & current research trends shows that progressively
natural polymers are replacing synthetic polymers in the fabrication of GRDDS as they are more
safe, non-toxic, biodegradable, biocompatible, economical, regulatory acceptance, etc. Also, it has
been noticed by the researchers that natural polymer due to their properties have successfully amplified
gastric residence time, dissolution & bioavailability of the gastroretentive dosage forms.
Isotype Profile of Specific Antibodies after Chronic Exposure to Microcystins
Authors: Ruiz Marcia A. , Ferrari Alejandro , Rodriguez Maria I. , Flanagan Cristian , Lerda Daniel , Romero Marta D. , Halac Silvana R. , Ruibal-Conti Ana L. 
Published: October 2024

Background:
The detection of microcystins in blood, respiratory mucosa, and urine samples to diagnose acute or chronic microcystin intoxication is difficult and requires sophis-ticated analysis techniques. Finding simple and quick methods to assess the exposure of indi-viduals to microcystins is crucial.

Objective:
This study aims to assess the presence of specific antibodies (IgG, IgE, IgA, and IgM) against microcystin-LR in individuals exposed to cyanobacterial blooms as a non-com-plex biomarker.

Methods:
Blood samples were taken to reveal the presence of specific antibodies as well as to measure a standard set of biochemical parameters. All volunteers were administered a ques-tionnaire regarding their water usage, health status, and habits. Significant differences in the antibody content were studied between exposed and non-exposed people to cyanobacterial blooms.

Results:
We found that out of 73 studied individuals, 87.7% of them showed positive results for at least one of the four types of antibodies tested. The prevalent isotype was IgE, and sig-nificant differences were detected for all isotypes between the exposed and non-exposed groups. The biochemical profile was altered in some cases.

Conclusion:
The presence of specific antibodies in serum could be used as exposure biomarkers to complement epidemiological studies and medical diagnosis of microcystin intoxications. The in-house ELISA method, developed by our group for the detection of antibodies, should now be improved in terms of specificity and accuracy. These findings also indicate that more re-search should be conducted on the protective role and duration of antibodies.
Impact of Ultra-Processed Foods on Food Sustainability: Exposure Assessment and Health Implications
Authors: Chadha Muskan , Shukla Ratnakar , Kumar Tiwari Rohit , Kumar Dubey Dharmendra , Singh Karuna 
Published: October 2024

Abstract:
Excessive consumption of ultra-processed food (UPF) is a global health concern as-sociated with an increased incidence of non-communicable diseases. UPFs are characterized by their extensive industrial processing and high content of additives, preservatives, chemicals, and artificial ingredients that are used to mask defects or inferior ingredients of end food products, presenting a multifaceted challenge to contemporary society. Exposure assessment showed that almost 50% to 30% of the energy consumption per day comes from UPFs. The more processed a food is, the less likely it is to be healthy and nutritious. UPFs affect human health by increasing the risk of obesity, heart disease, cancer, depression, diabetes, etc., as these foods are typically made up of a large number of preservatives, high content of fats, sodium, and sugars, and low contents of protein, fiber, and potassium. The ingredients required for the production of UPFs are commonly derived from intensive monoculture and livestock of raw foods. This, in turn, exerts imminent effects on agriculture, biodiversity, and the global food system by altering the bioavailability of nutrients within agricultural soil, thereby increasing the dependency on ferti-lizers and insecticides. Recent studies have shown that over-consumption of UPF has an effect on culinary traditions, loss of biodiversity, human well-being, and food system sustainability. Therefore, for better food system sustainability, the consumption of UPFs should be reduced, and we should move toward minimal processing technologies, preferably for seasonal and or-ganic local products. Based on available data, there is an urgent need to implement policies and regulations for the agro-food industry to include nutritional and environmental criteria. This review explains the different dimensions of UPFs in relation to health, nutrition, environment, current challenges, future innovations, and wider sustainability concerns.
Aphrodisiac Activity of Beligo (Benincasa hispida (Thunb.) Cogn.) Seeds of Ethanol Extract in Mice
Authors: Alim Nur , Jasmiadi Jasmiadi , Nadillah Nadia , Indrawaty Kadir Ira , Afirah Nur 
Published: October 2024

Beligo (Benincasa hispida (Thunb.) Cogn.), is empirically used by the people of South Sulawesi-Indonesia as an aphrodisiac. Beligo seeds contain alkaloids, phenolics, flavonoids, and unsaturated fatty acids, which have the potential to act as aphrodisiacs. The primary objective of this research is to determine the aphrodisiac activity of an ethanol extract from beligo seeds in mice. The procedure entails extraction and aphrodisiac evaluation using introduction, climbing, and coitus test parameters. Aphrodisiac testing was carried out for seven days using 25 mice as experimental animals, divided into five groups. Each group consists of four males and one female. Group I was given Sod. CMC 1% as a negative control; II, III, and IV were given ethanol extracts of beligo seeds at doses of 350mg/kg, 700mg/kg, 1400mg/kg BW, and group V, as a positive control, was given Yohimbine. The results showed that the ethanol extract of beligo seeds at doses of 350mg/kg BW, 700mg/kg BW, and 1400mg/kg BW had aphrodisiac activity (p=0.0001) compared to Sod. CMC 1% based on data on the amount of introduction and climbing. However, based on data on the number of coitus, it showed that the ethanol extract of beligo seeds at doses of 350mg/kg BW (p=0.072) had no aphrodisiac activity, 700mg/kg BW (p=0.007), 1400mg/kg BW (p=0.0001) had aphrodisiac activity compared to Na-CMC 1% and only a dose of 1400 mg/kg BW had the same aphrodisiac activity compared with Yohimbine (p=0.967). It is concluded that the ethanol extract of beligo seeds had aphrodisiac activity.
Social Gaming to Decrease Loneliness in Older Adults: Recruitment Challenges and Attrition Analysis in a Digital Mixed Methods Feasibility Study
Authors: Châtel Bas D L , Janssen Jeroen H M , Peeters Geeske M E E , Corten Rense , Tieben Rob , Deen Menno , Hendriks Elmy J M , Olde Rikkert Marcel G M 
Published: October 2024

Background
Digital mental health interventions could sustainably and scalably prevent and reduce loneliness in older adults. We designed an app containing 29 text-based games and a questionnaire-administering chatbot to stimulate intergenerational contact.

Objective
This study aims to evaluate the feasibility of a social gaming app in reducing loneliness among older adults by evaluating recruitment strategies, data collection procedures, and gameplay activity.

Methods
This mixed methods study recruited participants via newsletters, articles, and a social media campaign. We used semistructured interviews and descriptive analysis of questionnaire answers and game data to assess feasibility. Key measures included recruitment reach and efficiency, participant demographics, in-app activity, and app usability and engagement feedback.

Results
The social media campaign reached 192,641 potential participants, resulting in 1363 game downloads. A total of 155 participants (aged 65 years and older: n=34, 21.9% and aged less than 65 years: n=121, 78.1%) provided informed consent, yielding a conversion rate of 0.08%. The recruitment campaign focusing on distanced playful interaction had a significantly (P<.001) higher click-through rate (1.98%) than a campaign focusing on research participation (click-through rate=0.51%; P<.001). The overall conversion rate from advertisement exposure to research participation was 0.08%. Participants had a mean age of 48 (SD 16) years. The 65 years and older group averaged 70 (SD 5) years, while the less 65 years group averaged 42 (SD 12) years. Additionally, 45.2% (57/126) reported at least moderate levels of loneliness at baseline. Of the initial 554 players, 91 (16.4%) remained active after the first week, and 32 (5.8%) remained active for more than 90 days. Active participants tended to interact with those within their own age group, as indicated by a Pearson correlation of r=0.31 between the ages of the message sender and receiver. Interviews with 12 (48%) participants (aged 65-79 years; female: n=12, 83%) revealed barriers such as excessive chatbot questions and a mismatch between the target group and app design focus. Questionnaire completion rates dropped from 46% at baseline to 10% at follow-up.

Conclusions
These findings underscore the challenges of recruitment and retention for older adults in a fully digital social gaming intervention. Effective recruitment strategies and targeted app design are crucial for engagement. Based on these insights, future interventions should focus on simplified interfaces, clear guidance for gameplay, and addressing the specific needs and preferences of older adults, thereby enhancing the effectiveness of digital mental health interventions.
Perceptions of Illness Control, Coherence, and Self-Efficacy Following a Web-Based Lifestyle Program for Multiple Sclerosis: A Qualitative Analysis of Semistructured Interviews
Authors: Davenport Rebekah , Bevens William , Neate Sandra , Jelinek Pia , Yu Maggie , Jelinek George , Reece Jeanette 
Published: October 2024

Background
Evidence suggests that illness perceptions held by people living with multiple sclerosis (MS) impact affective distress and physical health outcomes. In a randomized controlled trial, we developed 2 MS Online Courses—the standard care course and the intervention course (IC). The IC was adapted from an evidence-based lifestyle program. Modifying lifestyle risk factors offers an opportunity to impact illness perceptions. Research on illness perceptions in people living with MS has focused predominately on quantitative methods.

Objective
This study aimed to explore the experiences and health outcomes of randomized controlled trial participants, including individuals’ perceived changes in attitudes toward MS and their health (ie, illness perceptions).

Methods
Qualitative responses provided by 38 participants (22 in the IC and 16 in the standard care course) were derived from semistructured interviews 1 month after completing the MS Online Course. The impact of course engagement and lifestyle modification on illness perceptions was explored using inductive thematic analysis.

Results
Themes of changes in illness perceptions were most prominent in the IC arm. Qualitative responses from 22 people living with MS informed the development of three themes: “self-efficacy for disease management,” “personal control,” and “illness coherence.”

Conclusions
Findings provide novel insights into the formation and modification of illness perceptions. Lifestyle modification may serve as a valuable adjunct to clinician-administered therapies, improving the sense of personal control over MS, illness coherence, and self-efficacy for disease management.

Trial Registration
Australian New Zealand Clinical Trials Registry ACTRN12621001605886; https://tinyurl.com/2vyve9p9

International Registered Report Identifier (IRRID)
RR2-10.1186/s12883-023-03298-0
Exploring the Intersection of Schizophrenia, Machine Learning, and Genomics: Scoping Review
Authors: Hudon Alexandre , Beaudoin Mélissa , Phraxayavong Kingsada , Potvin Stéphane , Dumais Alexandre 
Published: October 2024

Background
An increasing body of literature highlights the integration of machine learning with genomic data in psychiatry, particularly for complex mental health disorders such as schizophrenia. These advanced techniques offer promising potential for uncovering various facets of these disorders. A comprehensive review of the current applications of machine learning in conjunction with genomic data within this context can significantly enhance our understanding of the current state of research and its future directions.

Objective
This study aims to conduct a systematic scoping review of the use of machine learning algorithms with genomic data in the field of schizophrenia.

Methods
To conduct a systematic scoping review, a search was performed in the electronic databases MEDLINE, Web of Science, PsycNet (PsycINFO), and Google Scholar from 2013 to 2024. Studies at the intersection of schizophrenia, genomic data, and machine learning were evaluated.

Results
The literature search identified 2437 eligible articles after removing duplicates. Following abstract screening, 143 full-text articles were assessed, and 121 were subsequently excluded. Therefore, 21 studies were thoroughly assessed. Various machine learning algorithms were used in the identified studies, with support vector machines being the most common. The studies notably used genomic data to predict schizophrenia, identify schizophrenia features, discover drugs, classify schizophrenia amongst other mental health disorders, and predict the quality of life of patients.

Conclusions
Several high-quality studies were identified. Yet, the application of machine learning with genomic data in the context of schizophrenia remains limited. Future research is essential to further evaluate the portability of these models and to explore their potential clinical applications.
The Implementation Outcomes and Population Impact of a Statewide IT Deployment for Family Caregivers: Mixed Methods Study
Authors: Tonkikh Orly , Young Heather M , Bell Janice F , Famula Jessica , Whitney Robin , Mongoven Jennifer , Kelly Kathleen 
Published: October 2024

Background
In 2022, the US Department of Health and Human Services released the first National Strategy to Support Family Caregivers, identifying actions for both government and the private sector. One of the major goals is to expand data, research, and evidence-based practices to support family caregivers. While IT tools are widely deployed in health care settings, they are rarely available at scale in community agencies. In 2019, the state of California recognized the importance of a statewide database and a platform to serve caregivers remotely by enhancing existing service supports and investing in a web-based platform, CareNav. Implementation commenced in early 2020 across all 11 California Caregiver Resource Centers.

Objective
This paper describes the implementation strategies and outcomes of the statewide implementation of CareNav, a web-based platform to support family caregivers.

Methods
The Consolidated Framework for Implementation Research (CFIR), including a recent addendum, guided this mixed methods evaluation. Two major approaches were used to evaluate the implementation process: in-depth qualitative interviews with key informants (n=82) and surveys of staff members (n=112) and caregivers (n=2229). We analyzed the interview transcripts using qualitative descriptive methods; subsequently, we identified subthemes and relationships among the ideas, mapping the findings to the CFIR addendum. For the surveys, we used descriptive statistics.

Results
We present our findings about implementation strategies, implementation outcomes (ie, adoption, fidelity, and sustainment), and the impact on population health (organizational effectiveness and equity, as well as caregiver satisfaction, health, and well-being). The platform was fully adopted within 18 months, and the system is advancing toward sustainment through statewide collaboration. The deployment has augmented organizational effectiveness and quality, enhanced equity, and improved caregiver health and well-being.

Conclusions
This study provides a use case for technological implementation across a multisite system with diverse community-based agencies. Future research can expand the understanding of the barriers and facilitators to achieving relevant outcomes and population impact.
Walter Schuetze and the Numbers Game: Advocate for Reform, Champion of Independence, Promoter of Fair Value, and Proponent of Simplification
Authors: Foltin Craig , Flesher Dale L. 
Published: October 2024

ABSTRACT
This paper examines the life of Walter Schuetze (1932–2017) and his contributions to the accounting profession. He was a public accountant, a founding member of the Financial Accounting Standards Board (FASB), the Chief Accountant for the United States Securities and Exchange Commission (SEC), a corporate board member, and an advocate for accounting reform. In 2008, he was inducted into the Accounting Hall of Fame. This paper shows how Walter Schuetze has left a quiet but impactful legacy with lessons learned that still have applicability to the accounting profession today.
Audit Quality Under Remote Working Arrangement: The Role of Technology Competency
Authors: Hsieh Tien-Shih , Tang Zhenyang , Wang Zhihong , Yoon Kyunghee 
Published: October 2024

ABSTRACT
Using comprehensive labor market data to measure client firms’ workforce technology competency, this study investigates how companies’ workforce technology competency may mitigate the deterioration of audit quality under the remote working arrangement following COVID-19. Our results suggest that after the COVID-19 outbreak, companies’ accrual quality has decreased, indicating a deterioration of audit quality. The negative impact of remote audits during COVID-19 on audit quality is less pronounced in companies with greater workforce technology competency. Our results are robust to various alternative measures, local versus nonlocal client analysis, and nonhigh-technology industry analysis. Our study provides important implications for regulatory bodies and industry professionals to understand the importance of technological human capital in improving audit quality in remote auditing contexts.
Data Availability: Data are obtained from the sources specified in the paper.
JEL Classifications: M15; M42.
The Adoption of Blockchain Technology on Company’s Internal Control System in Sales and Purchasing Cycle
Authors: Lin Yu-Cheng , Padliansyah Roni , Wu Pei-Pei 
Published: October 2024

ABSTRACT
This paper explores the use of blockchain technology to enhance internal control systems for fraud prevention within the sales and purchasing cycle. Despite existing internal controls, significant weaknesses persist in these systems, leading to issues such as poor performance, missing orders, underpricing, rebates, false charges, falsification of order information, late delivery, and order/performance shifting. Using the design science research approach (Hevner, March, Park, and Ram 2004), we propose a conceptual framework that allocates the verification, storage, and management of events to each authorized blockchain node, preventing tampering with verified data. By integrating blockchain’s secure, traceable, and decentralized features with smart contracts, oracles, and the Internet of Things (IoT), our framework aims to automate workflows, track goods in real-time, and measure operational performance accurately. This approach enhances internal control systems, reduces audit workloads, and mitigates the risk of business fraud and misconduct.
JEL Classifications: M42; M49.