bluuebunny/crossref_metadata_2025_split huggingface dataset:
Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats
Authors: Dai Qinggang , Zhou Siru , Zhang Peng , Ma Xuhui , Ha Nayong , Yang Xiao , Yu Zhifeng , Fang Bing , Jiang Lingyong 
Published: June 2017

AbstractAs the number of elderly orthodontic patients increases, the impact of postmenopausal osteoporosis on orthodontic tooth movement (OTM) has attracted a great deal of attention because OTM relies on alveolar bone remodeling. The question of whether OTM causes subsequent alveolar bone loss and is harmful to alveolar bone health under osteoporotic conditions remains to be answered. The present study aimed to clarify the influences of OTM on alveolar bone in osteoporotic rats. OTM was accelerated in ovariectomized (OVX) rats as a result of increased bone resorption in the pressure area. At the same time, anabolic bone formation was promoted in the tension area during OTM in OVX rats. Micro-CT analysis of alveolar bone revealed a decrease in BMD, BV/TV and Tb.Th. in the OTM group compared with that in non-OTM rats on day 21 of OTM, suggesting that OTM caused alveolar bone loss in OVX rats during OTM. However, the OTM-induced bone loss could be recovered 3 months after OTM in OVX rats. Thus, our findings suggest that increased osteogenesis may compensate for the increased bone resorption during and after OTM and enable effective accelerated OTM in OVX rats.
The Effectiveness of the Progression of Widex Zen Tinnitus Therapy: A Pilot Study
Authors: Tyler Richard S. , Deshpande Aniruddha K. , Lau Chi C. , Kuk Francis 
Published: June 2017

Purpose
The aim of this study was to measure the progression of benefits to individuals with tinnitus from providing informational counseling, hearing aids, a brief tinnitus activities treatment and Zen therapy.

Method
Several magnitude estimation scales and tinnitus handicap scales were administered for the duration of the study to 20 participants.

Results
Results indicated that all participants benefited from this sequential approach of providing different components of this tinnitus treatment. Large benefits were observed following the tinnitus activities treatment and the Zen treatments.

Conclusion
We conclude that the progressive approach of treatment demonstrated here should be of benefit to most individuals with tinnitus and that the Widex Zen sound therapy is a worthwhile treatment for many tinnitus sufferers.
Dynamic Assessment for 3- and 4-Year-Old Children Who Use Augmentative and Alternative Communication: Evaluating Expressive Syntax
Authors: Binger Cathy , Kent-Walsh Jennifer , King Marika 
Published: June 2017

PurposeThe developmental readiness to produce early sentences with an iPad communication application was assessed with ten 3- and 4-year-old children with severe speech disorders using graduated prompting dynamic assessment (DA) techniques. The participants' changes in performance within the DA sessions were evaluated, and DA performance was compared with performance during a subsequent intervention.MethodDescriptive statistics were used to examine patterns of performance at various cueing levels and mean levels of cueing support. The Wilcoxon signed-ranks test was used to measure changes within the DA sessions. Correlational data were calculated to determine how well performance in DA predicted performance during a subsequent intervention.ResultsParticipants produced targets successfully in DA at various cueing levels, with some targets requiring less cueing than others. Performance improved significantly within the DA sessions—that is, the level of cueing required for accurate productions of the targets decreased during DA sessions. Last, moderate correlations existed between DA scores and performance during the intervention for 3 out of 4 targets, with statistically significant findings for 2 of 4 targets.ConclusionDA offers promise for examining the developmental readiness of young children who use augmentative and alternative communication to produce early expressive language structures.
Early Sentence Productions of 3- and 4-Year-Old Children Who Use Augmentative and Alternative Communication
Authors: Binger Cathy , Kent-Walsh Jennifer , King Marika , Mansfield Lindsay 
Published: June 2017

Purpose
This study investigated the early rule-based sentence productions of 3- and 4-year-old children with severe speech disorders who used single-meaning graphic symbols to communicate.

Method
Ten 3- and 4-year-olds requiring the use of augmentative and alternative communication, who had largely intact receptive language skills, received instruction in producing up to four different semantic–syntactic targets using an Apple iPad with a communication app. A single-case, multiple-probe, across-targets design was used to assess the progress of each participant and target. Generalization to new vocabulary was assessed, and a subgroup also was taught to produce sentences using grammatical markers.

Results
Some targets (primarily possessor-entity) were mastered in the baseline phase, and the majority of the remaining targets were mastered during intervention. All four children who completed intervention for grammatical markers quickly learned to use the markers accurately.

Conclusions
Expressive language potential for preschoolers using graphic symbol–based augmentative and alternative communication systems should not be underestimated. With appropriate presentation and intervention techniques, some preschoolers with profound speech disorders can readily learn to produce rule-based messages via graphic symbols.
Using Network Science Measures to Predict the Lexical Decision Performance of Adults Who Stutter
Authors: Castro Nichol , Pelczarski Kristin M. , Vitevitch Michael S. 
Published: June 2017

Purpose
Methods from network science have examined various aspects of language processing. Clinical populations may also benefit from these novel analyses. Phonological and lexical factors have been examined in adults who stutter (AWS) as potential contributing factors to stuttering, although differences reported are often subtle. We reexamined the performance of AWS and adults who do not stutter (AWNS) from a previously conducted lexical decision task in an attempt to determine if network science measures would provide additional insight into the phonological network of AWS beyond traditional psycholinguistic measures.

Method
Multiple regression was used to examine the influence of several traditional psycholinguistic measures as well as several new measures from network science on response times.

Results
AWS responded to low-frequency words more slowly than AWNS; responses for both groups were equivalent for high-frequency words. AWS responded to shorter words more slowly than AWNS, producing a reverse word-length effect. For the network measures, degree/neighborhood density and closeness centrality, but not whether a word was inside or outside the giant component, influenced response times similarly between groups.

Conclusions
Network analyses suggest that multiple levels of the phonological network might influence phonological processing, not just the micro-level traditionally considered by mainstream psycholinguistics.
Fault diagnosis of rotor winding inter‐turn short circuit for sensorless synchronous generator through screw
Authors: Yucai Wu , Qianqian Ma , Bochong Cai 
Published: June 2017

Timely and accurate detection of the rotor winding inter‐turn short‐circuit fault of a synchronous generator can reduce the more serious damages caused by fault deterioration and economic losses, so developing online detection methods with high sensitivity is necessary. On the basis of the structural characteristics of the synchronous generator, this study proposes a sensorless online detection method for rotor winding inter‐turn short‐circuit faults, respectively, taking a 300 MW turbo generator and a 550 MW hydro‐generator as the objects of finite‐element simulation. The results show that the new fault diagnosis method of the rotor winding inter‐turn short circuit for the sensorless synchronous generator has high sensitivity and can realise real‐time monitoring of the faults.
One‐day ahead wind speed/power prediction based on polynomial autoregressive model
Authors: Karakuş Oktay , Kuruoğlu Ercan E. , Altınkaya Mustafa A. 
Published: June 2017

Wind has been one of the popular renewable energy generation methods in the last decades. Foreknowledge of power to be generated from wind is crucial especially for planning and storing the power. It is evident in various experimental data that wind speed time series has non‐linear characteristics. It has been reported in the literature that nonlinear prediction methods such as artificial neural network (ANN) and adaptive neuro fuzzy inference system (ANFIS) perform better than linear autoregressive (AR) and AR moving average models. Polynomial AR (PAR) models, despite being non‐linear, are simpler to implement when compared with other non‐linear AR models due to their linear‐in‐the‐parameters property. In this study, a PAR model is used for one‐day ahead wind speed prediction by using the past hourly average wind speed measurements of Çeşme and Bandon and performance comparison studies between PAR and ANN‐ANFIS models are performed. In addition, wind power data which was published for Global Energy Forecasting Competition 2012 has been used to make power predictions. Despite having lower number of model parameters, PAR models outperform all other models for both of the locations in speed predictions as well as in power predictions when the prediction horizon is longer than 12 h.
Fatigue assessment by electroencephalogram measured with candle‐like dry microneedle electrodes
Authors: Kudo Yuta , Arai Miyako , Miki Norihisa 
Published: June 2017

This work reports on the creation of an electroencephalogram (EEG) index and the discovery of a power ratio related to alpha band frequencies (8–13 Hz) that were experimentally found to have a high correlation with human mental fatigue. The EEG was measured from occipital lobe of the human brain by microfabricated dry candle‐like microneedle electrodes (CMEs) that can avoid hairs and penetrate through the high‐impedance stratum corneum. The newly identified EEG index exhibited higher correlations to mental fatigue states, which were rated subjectively via the visual analogue scale (VAS), than did heart rate variance, which is often used as the objective measure of fatigue levels. Interestingly, it was found that the index trend changed 10 min before the VAS did, which implies that the index could assess the onset of mental fatigue even before the subjects recognised it themselves. The identification of this EEG index, along with the ease of obtaining EEG measurements via CME, which is due to the fact that the CME does not require any skin preparation or conductive gels and can acquire EEGs from hair‐covered parts of the scalp, can be expected to promote practical fatigue assessment applications that use EEGs.
Concept of Combined Femoral and Tibial Osteotomies
Authors: Sigwalt Loic , Rubens-Duval Brice , Chedal-Bornu Billy , Pailhe Regis , Saragaglia Dominique 
Published: June 2017

AbstractMedial knee osteoarthritis is not uncommon, and high tibial osteotomy (HTO) for some surgeons is a unique treatment option for young and active patients. However, the deformity is not always located at the level of proximal part of the tibia and the overcorrection needed to achieve a lasting functional result can lead to an oblique joint line. To avoid this undesirable effect to the joint line, a double-level osteotomy (DLO), one at the distal part of the femur and another one at the proximal part of the tibia, is a viable option. The aim of this article is to present the preoperative radiological assessment, the operative procedure, the indications of HTO, distal femoral osteotomy (DFO), and DLO presenting the rationale behind the treatment options. Long-leg radiographs are mandatory to measure the hip–knee–ankle angle, and the femoral and tibial mechanical axes to plan the location of the osteotomy. The best indication for DLO is a severe varus knee deformity with femoral and tibial mechanical axes in varus. This argument can be applied to a genu valgum deformity, especially when the femur is in valgus as well as the tibia, which is not rare. Although the operative technique is demanding, the biggest challenge is not the procedure itself but rather how to reach the exact degree of overcorrection. Computer-assisted surgery is a good alternative and can improve the accuracy of the surgery.
A Less Invasive Approach to Periacetabular Osteotomy Improves Patient Reported Outcomes without Compromising Orientation
Authors: Pelt Christopher , Wingert Nathaniel , Erickson Jill , Anderson Mike , Peters Christopher 
Published: June 2017

AbstractA less-invasive modification of the approach to periacetabular osteotomy (PAO) has recently been popularized by sparing the rectus femoris origin (RS-PAO). The RS-PAO approach with its lack of intra-articular inspection and associated treatment is novel, and there are few published results on the outcomes following this technique. We report on a consecutive series of RS-PAO cases, including patient reported outcomes (PROs), acetabular fragment reorientation, and complications. We reviewed a consecutive series of 103 patients (103 procedures) who underwent RS-PAO from June 2012 to January 2016 with a mean 2-year follow-up. We collected PROs, radiographic, and clinical outcomes. PROs consisted of PROMIS (Patient Reported Outcomes Measurement Information System) measures covering the domains of physical function, mental health, and a numeric pain score (NPS). Physical function and mental health were reported as standardized T-scores. Appropriate bivariate statistics were used for the analyses. Physical function improved from a preoperative mean of 39.9 (95% confidence interval [CI], 38.0–42.0) to a postoperative value of 50.0 T-score units (95% CI, 47.01–52.7; dav = 1.2). The PROMIS global mental-health T-scores improved from a preoperative median of 45.8 (interquartile range [IQR], 41.1–50.8) to a postoperative value of 53.3 (IQR, 50.8–59.0; p < 0.001, correlation coefficient [r] = 0.77). Pain decreased from a median preoperative value of 6 (IQR, 3–8) to a postoperative value of 2 (IQR, 1–3; p < 0.001, r = 0.71). The postoperative acetabular index (AI) was within the correction goal in 75% of the cases (77/103) and lateral center-edge angle (LCEA) was within goal in 87% (90/103) of the cases. Complications included intraoperative ischial fracture (n = 1), nonunion of the superior ramus (n = 1), ischiofemoral impingement (n = 1), delayed union (n = 1), and wound dehiscence (n = 2). There have been no reoperations for intra-articular pathology. The data demonstrated that using the RS-PAO technique without concomitant intra-articular work allows for appropriate acetabular positioning as well as significant improvement in physical function, mental health, and pain with an acceptable short-term complication profile and low rate of reoperation.
Combined Effect of the PGR +331C > T, CYP17A1 -34A > G and CYP19A1 1531G > A Polymorphisms on the Risk of Developing Endometriosis
Authors: Cardoso Jéssica Vilarinho , Machado Daniel Escorsim , Ferrari Renato , Silva Mayara Calixto da , Berardo Plínio Tostes , Perini Jamila Alessandra 
Published: June 2017

Purpose To evaluate the magnitude of the association of the polymorphisms of the genes PGR, CYP17A1 and CYP19A1 in the development of endometriosis.
Methods This is a retrospective case-control study involving 161 women with endometriosis (cases) and 179 controls. The polymorphisms were genotyped by real-time polymerase chain reaction using the TaqMan system. The association of the polymorphisms with endometriosis was evaluated using the multivariate logistic regression.
Results The endometriosis patients were significantly younger than the controls (36.0 ± 7.3 versus 38.0 ± 8.5 respectively, p = 0.023), and they had a lower body mass index (26.3 ± 4.8 versus 27.9 ± 5.7 respectively, p = 0.006), higher average duration of the menstrual flow (7.4 ± 4.9 versus 6.1 ± 4.4 days respectively, p = 0.03), and lower average time intervals between menstrual periods (25.2 ± 9.6 versus 27.5 ± 11.1 days respectively, p = 0.05). A higher prevalence of symptoms of dysmenorrhea, dyspareunia, chronic pelvic pain, infertility and intestinal or urinary changes was observed in the case group when compared with the control group. The interval between the onset of symptoms and the definitive diagnosis of endometriosis was 5.2 ± 6.9 years. When comparing both groups, significant differences were not observed in the allelic and genotypic frequencies of the polymorphisms PGR +331C > T, CYP17A1 -34A > G and CYP19A1 1531G > A, even when considering the symptoms, classification and stage of the endometriosis. The combined genotype PGR +331TT/CYP17A1 -34AA/CYP19A11531AA is positively associated with endometriosis (odds ratio [OR] = 1.72; 95% confidence interval [95%CI] = 1.09–2.72).
Conclusions The combined analysis of the polymorphisms PGR-CYP17A1-CYP19A1 suggests a gene-gene interaction in the susceptibility to endometriosis. These results may contribute to the identification of biomarkers for the diagnosis and/or prognosis of the disease and of possible molecular targets for individualized treatments.
Der Patient mit Thoraxtrauma: anästhesiologisches Management
Authors: Kozian Alf , Bergmann Astrid , Hachenberg Thomas , Schilling Thomas 
Published: June 2017

ZusammenfassungIn der anästhesiologischen Praxis ist das Thoraxtrauma eine große Herausforderung. Verletzungen von Atemwegen, Lunge, Zwerchfell, Herz und großen thorakalen Gefäßen sind die vorherrschenden Probleme. Art und Ausmaß des chirurgischen Eingriffs sowie Wirkungen von Anästhetika und mechanischer Ventilation auf die pulmonale und kardiale Funktion sind besonders zu beachten.
Der Patient mit Thoraxtrauma: präklinische Versorgung
Authors: Hansen Michael , Hachenberg Thomas 
Published: June 2017

ZusammenfassungEtwa jeder 10. Traumapatient in den Notaufnahmen weist ein stumpfes Thoraxtrauma auf, aus dem lebensbedrohliche Verletzungen wie Spannungspneumothorax oder Perikardtamponade resultieren können. Zeitkritische Diagnostik und Therapie stehen bei der Versorgung im Vordergrund. Die Durchführung lebensrettender therapeutischer Maßnahmen muss jedem Notarzt geläufig sein, und das Verletzungsmuster entscheidet über die Auswahl der Zielklinik.
Primary Fetal Lung Hypoplasia (PFLH): Imaging and Clinical Characteristics
Authors: Achiron Reuven , Gilboa Yinon , Salem Yishay , Jacobson Yizhak , Raviv-Zilka Lisa , Cioca Andreea , Kidron Debora , Kivilevitch Zvi 
Published: June 2017

Abstract
Purpose To describe in utero and postnatal imaging and clinical characteristics of primary fetal lung hypoplasia (PFLH).
Methods A retrospective review of fetuses and neonates diagnosed in one academic tertiary center during an eleven-year period.
Results 12 cases of PFLH were identified. 4 were bilateral and 8 had unilateral involvement. Prenatal sonographic characteristics, postnatal magnetic resonance imaging (MRI), computerized tomographic angiography (CTA), and histologic findings are described. 3 of the 4 bilateral cases were evaluated during fetal live. 2 were terminated and 2 died shortly after delivery. Among the 8 cases with unilateral PFLH, 7 involved the right lung and 1 the left lung. In fetuses with right hypoplasia, 5 showed characteristic features of Scimitar syndrome, while associated gastrointestinal tract (GIT) anomalies were presented in 2 cases. In this group 3 were born alive and the other 5 were terminated.
Conclusion Primary PFLH is a rare anomaly that lethal in its bilateral form and with variable prognosis in its unilateral variant. Targeted evaluation of lung vascularity and exclusion of associated anomalies, especially of the GIT, are important prognostic factors.
Medizinische Versorgung von Flüchtlingen: Chancen und Herausforderungen in Hamburg – ein Praxisbericht
Authors: Jakubowski Elke , Rau Cornelius , Quellhorst Sibylle , Sothmann Peter , Plenge-Bönig Anita , Niessen Johannes 
Published: June 2017

ZusammenfassungDie stark gestiegenen Zahlen von Menschen auf der Flucht stellen insbesondere deutsche Großstädte vor Herausforderungen. Im Jahr 2015 meldeten sich in Hamburg 40 868 Schutzsuchende, von denen 22 315 aufgenommen wurden. Ziel der medizinischen Grundversorgung ist es, auf die besonderen gesundheitlichen Risiken und Bedürfnisse der Asylsuchenden einzugehen und gleichzeitig einen möglichst raschen Übergang in das Regelsystem zu ermöglichen. Öffentliche Stellen, Hilfsorganisationen und die Zivilgesellschaft arbeiten dazu Hand in Hand. In allen Hamburger Erstaufnahmeeinrichtungen werden von Übersetzern begleitete medizinische Sprechstunden in voll ausgestatteten Arztpraxiscontainern angeboten. Pro 1 000 Asylsuchenden stehen ein Arzt und eine medizinische Assistenzkraft vollzeitig zur Verfügung. Neben Honorarkräften beteiligen sich auch Mitarbeiter vertraglich eingebundener Krankenhäuser an der Versorgung. Die systematische Erhebung von Daten über den Gesundheitszustand der Asylsuchenden sowie die Stärkung des Öffentlichen Gesundheitsdienstes sind Schlüsselfaktoren, um die Versorgung zukünftig zu planen und zu verbessern. Die Schaffung eines gesünderen Lebensumfeldes und der Zugang zum medizinischen Regelsystem bieten die Chance, eine erfolgreiche Integration der Asylsuchenden in die Gesellschaft zu unterstützen.
Recommended Ideal-Gas Thermochemical Functions for Heavy Water and its Substituent Isotopologues
Authors: Simkó Irén , Furtenbacher Tibor , Hrubý Jan , Zobov Nikolai F. , Polyansky Oleg L. , Tennyson Jonathan , Gamache Robert R. , Szidarovszky Tamás , Dénes Nóra , Császár Attila G. 
Published: June 2017

Accurate temperature-dependent ideal-gas internal partition functions, Qint(T), and several derived thermochemical functions are reported for heavy water, with an oxygen content corresponding to the isotopic composition of Vienna Standard Mean Ocean Water (VSMOW), and its constituent isotopologues, D216O, D217O, and D218O, for temperatures between 0 and 6000 K. The nuclear-spin-dependent partition functions are obtained by the direct summation technique, involving altogether about 16 000 measured and more than nine million computed bound rovibrational energy levels for the three molecules. Reliable standard uncertainties, as a function of temperature, are estimated for each thermochemical quantity determined, including the enthalpy, the entropy, and the isobaric heat capacity of the individual nuclear-spin-equilibrated isotopologues and of heavy water. The accuracy of the heavy-water ideal-gas Cp(T) is unprecedented, below 0.01% up to 1800 K. All the thermochemical functions are reported, in 1 K increments, in the supplementary material.
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing
Authors: Fei Teng , Chen Yiwen , Xiao Tengfei , Li Wei , Cato Laura , Zhang Peng , Cotter Maura B. , Bowden Michaela , Lis Rosina T. , Zhao Shuang G. , Wu Qiu , Feng Felix Y. , Loda Massimo , He Housheng Hansen , Liu X. Shirley , Brown Myles 
Published: June 2017

Significance
Alternative RNA splicing and the spliceosome machinery have been implicated in cancer progression. A genome-wide CRISPR screen identified the RNA processing factor heterogeneous nuclear ribonucleoprotein L (HNRNPL) as required for prostate cancer growth by regulating alternative RNA splicing and circular RNA formation. HNRNPL and its RNA clients are overexpressed during prostate cancer progression, supporting their potential role as therapeutic targets.