bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete Genomic Sequences of Two Salmonella enterica subsp.
enterica
Serogroup C2 (O:6,8) Strains from Central California
Authors: Gorski Lisa , Huynh Steven , Cooper Kerry K. , Parker Craig T. 
Published: November 2017

ABSTRACT

Salmonella enterica
subsp.
enterica
strains RM11060, serotype 6,8:d:−, and RM11065, serotype 6,8:−:e,n,z
15
, were isolated from environmental samples collected in central California in 2009. We report the complete genome sequences of these two strains. These genomic sequences are distinct and will provide additional data to our understanding of
S. enterica
genomics.
Draft Genome Sequence of Entomopathogenic Brevibacillus laterosporus Strain Lak 1210, an Alkaliphilic Chitin Degrader
Authors: Prasanna Lakshmi , Moharana Tushar Ranjan , Sheikh Nizamuddin , Arravapalli Veerabhadra Rao , Kumaraswamy Thangaraj , Eijsink Vincent G. H. , Nalam Madhusudhana Rao 
Published: November 2017

ABSTRACT

We announce here the draft genome sequence of
Brevibacillus laterosporus
strain Lak 1210, isolated from mangrove soil. This alkaliphilic strain is an efficient chitin degrader and has the ability to control insects and inhibit phytopathogenic fungi. The assembly consists of 5,082,926 bp, with 4,321 protein-coding sequences and a GC content of 41.15%.
Are food and drink retailers within NHS venues adhering to NICE Quality standard 94 guidance on childhood obesity? A cross-sectional study of two large secondary care NHS hospitals in England
Authors: James Alice , Birch Laura , Fletcher Peter , Pearson Sally , Boyce Catherine , Ness Andy R , Hamilton-Shield Julian P , Lithander Fiona E 
Published: November 2017

ObjectiveTo assess whether the food and drink retail outlets in two major National Health Service (NHS) district general hospitals in England adhere to quality statements 1–3 of the UK National Institute for Health and Care Excellence (NICE) quality standard 94.DesignCross-sectional, descriptive study to assess the food and drink options available in vending machines, restaurants, cafes and shops in two secondary care hospitals.Main outcome measuresAdherence to quality statement 1 whereby the food and drink items available in the vending machines were classified as either healthy or less healthy using the Nutrient Profiling Model (NPM). Compliance with quality statements 2 and 3 was assessed through the measurement of how clearly the shops, cafes and restaurants displayed nutrition information on menus, and the availability and prominent display of healthy food and drink options in retail outlets, respectively.ResultsAdherence to quality statement 1 was poor. Of the 18 vending machines assessed, only 7 (39%) served both a healthy food and a healthy drink option. Neither hospital was compliant with quality statement 2 wherein nutritional information was not available on menus of food providers in either hospital. There was inconsistent compliance with quality standard 3 whereby healthy food and drink options were prominently displayed in the two main hospital restaurants, but all shops and cafes prioritised the display of unhealthy items.ConclusionsNeither hospital was consistently compliant with quality statements 1–3 of the NICE quality standard 94. Improving the availability of healthy foods and drinks while reducing the display and accessibility to less healthy options in NHS venues may improve family awareness of healthy alternatives. Making it easier for parents to direct their children to healthier choices is an ostensibly central component of our healthcare system.
Predictive value of apelin-12 in patients with ST-elevation myocardial infarction with different renal function: a prospective observational study
Authors: Yang Lingchang , Zheng Ting , Wu Haopeng , Xin Wenwei , Mou Xiongneng , Lin Hui , Chen Yide , Wu Xiaoyu 
Published: November 2017

ObjectivesTo investigate factors predicting the onset of major adverse cardiovascular events (MACEs) after primary percutaneous coronary intervention (pPCI) for patients with ST-segment elevation myocardial infarction (STEMI) .BackgroundApelin-12 plays an essential role in cardiovascular homoeostasis. However, current knowledge of its predictive prognostic value is limited.Methods464 patients with STEMI (63.0±11.9 years, 355 men) who underwent successful pPCI were enrolled and followed for 2.5 years. Multivariate cox regression analysis and receiver operating characteristic (ROC) curve analysis were performed to determine the factors predicting MACEs.Results118 patients (25.4%) experienced MACEs in the follow-up period. Multivariate cox regression analysis found low apelin-12 (HR=0.132, 95% CI 0.060 to 0.292, P<0.001), low left ventricular ejection fraction (HR=0.965, 95% CI 0.941 to 0.991, P=0.007), low estimated glomerular filtration rate (eGFR) (HR=0.985, 95% CI 0.977 to 0.993, P<0.001), Killip’s classification>I (HR=0.610, 95% CI 0.408 to 0.912, P=0.016) and pathological Q-wave (HR=1.536, 95% CI 1.058 to 2.230, P=0.024) were independent predictors of MACEs in the 2.5 year follow-up period. Low apelin-12 also predicted poorer in-hospital prognosis and MACEs in the 2.5 years follow-up period compared with Δapelin-12 (P=0.0115) and eGFR (P=0.0071) among patients with eGFR>90 mL/min×1.73 m2. Further analysis showed Δapelin-12 <20% was associated with MACEs in patients whose apelin-12 was below 0.76 ng/mL (P=0.0075) on admission.ConclusionsPatients with STEMI receiving pPCI with lower apelin-12 are more likely to suffer MACEs in hospital and 2.5 years postprocedure, particularly in those with normal eGFR levels.
Influence of Enzalutamide on Cabazitaxel Pharmacokinetics: a Drug–Drug Interaction Study in Metastatic Castration-resistant Prostate Cancer (mCRPC) Patients
Authors: Belderbos Bodine P.S. , Bins Sander , van Leeuwen Roelof W.F. , Oomen-de Hoop Esther , van der Meer Nelly , de Bruijn Peter , Hamberg Paul , Overkleeft Esther N.M. , van der Deure Wendy M. , Lolkema Martijn P. , de Wit Ronald , Mathijssen Ron H.J. 
Published: November 2017

Abstract
Purpose: In ongoing clinical research on metastatic castration-resistant prostate cancer (mCRPC) treatment, the potential enhanced efficacy of the combination of taxanes with AR-targeted agents, that is, enzalutamide and abiraterone, is currently being explored. Because enzalutamide induces the CYP3A4 enzyme and taxanes are metabolized by this enzyme, a potential drug–drug interaction needs to be investigated.
Experimental Design: Therefore, we performed a pharmacokinetic cross-over study in mCRPC patients who were scheduled for treatment with cabazitaxel Q3W (25 mg/m2). Patients were studied for three consecutive cabazitaxel cycles. Enzalutamide (160 mg once daily) was administered concomitantly after the first cabazitaxel cycle, during 6 weeks. Primary endpoint was the difference in mean area under the curve (AUC) between the first (cabazitaxel monotherapy) and third cabazitaxel cycle, when enzalutamide was added.
Results: A potential clinically relevant 22% (95% CI, 9%–34%; P = 0.005) reduction in cabazitaxel exposure was found with concomitant enzalutamide use. The geometric mean AUC0–24h of cabazitaxel was 181 ng*h/mL (95% CI, 150–219 ng*h/mL) in cycle 3 and 234 ng*h/mL (95% CI, 209–261 ng*h/mL) in cycle 1. This combination did not result in excessive toxicity, whereas PSA response was promising.
Conclusions: We found a significant decrease in cabazitaxel exposure when combined with enzalutamide. In an era of clinical trials on combination strategies for mCRPC, it is important to be aware of clinically relevant drug–drug interactions. Because recent study results support the use of a lower standard cabazitaxel dose of 20 mg/m2, the clinical relevance of this interaction may be substantial, because the addition of enzalutamide may result in subtherapeutic cabazitaxel exposure. Clin Cancer Res; 24(3); 541–6. ©2017 AACR.
Prognostic Stratification of Patients With ST-Segment–Elevation Myocardial Infarction (PROSPECT)
Authors: Pontone Gianluca , Guaricci Andrea I. , Andreini Daniele , Ferro Giovanni , Guglielmo Marco , Baggiano Andrea , Fusini Laura , Muscogiuri Giuseppe , Lorenzoni Valentina , Mushtaq Saima , Conte Edoardo , Annoni Andrea , Formenti Alberto , Mancini Maria Elisabetta , Carità Patrizia , Verdecchia Massimo , Pica Silvia , Fazzari Fabio , Cosentino Nicola , Marenzi Giancarlo , Rabbat Mark G. , Agostoni Piergiuseppe , Bartorelli Antonio L. , Pepi Mauro , Masci Pier Giorgio 
Published: November 2017

Background—
Cardiac magnetic resonance (CMR) is a robust tool to evaluate left ventricular ejection fraction (LVEF), myocardial salvage index, microvascular obstruction, and myocardial hemorrhage in patients with ST-segment–elevation myocardial infarction. We evaluated the additional prognostic benefit of a CMR score over standard prognostic stratification with global registry of acute coronary events (GRACE) score and transthoracic echocardiography LVEF measurement.

Methods and Results—

Two hundred nine consecutive patients with ST-segment–elevation myocardial infarction (age, 61.4±11.4 years; 162 men) underwent transthoracic echocardiography and CMR after succesful primary percutaneous coronary intervention. Major adverse cardiac events (MACE) were assessed at a mean follow-up of 2.5±1.2 years. MACE occurred in 24 (12%) patients who at baseline showed higher GRACE risk score (
P
<0.01), lower LVEF with both transthoracic echocardiography and CMR, lower myocardial salvage index, and higher per-patient myocardial hemorrhage and microvascular obstruction prevalence and amount as compared with patients without MACE (
P
<0.01). The best cut-off values of transthoracic echocardiography-LVEF, CMR-LVEF, myocardial salvage index, and microvascular obstruction to predict MACE were 46.7%, 37.5%, 0.4, and 2.6% of left ventricular mass, respectively. Accordingly, a weighted CMR score, including the following 4 variables (CMR-LVEF, myocardial salvage index, microvascular obstruction, and myocardial hemorrhage), with a maximum of 17 points was calculated and included in the multivariable analysis showing that only CMR score (hazard ratio, 1.867 per SD increase [1.311–2.658];
P
<0.001) was independently associated with MACE with the highest net reclassification improvement as compared to GRACE score and transthoracic echocardiography-LVEF measurement.

Conclusions—
CMR score provides incremental prognostic stratification as compared with GRACE score and transthoracic echocardiography-LVEF and may impact the management of patients with ST-segment–elevation myocardial infarction.
Association Between Stroke Risk and Metformin Use in Hemodialysis Patients With Diabetes Mellitus: A Nested Case–Control Study
Authors: Chien Li‐Nien , Chou Chu‐Lin , Chen His‐Hsien , Kao Chih‐Chin , Lin Yen‐Chung , Wu Yueh‐Lin , Chen Jin‐Shuen , Chen Li‐Ying , Fang Te‐Chao 
Published: November 2017

Background

Metformin use reduces the incidence and severity of stroke in patients with type 2 diabetes mellitus (
DM
). The benefits of metformin for stroke have not been examined in hemodialysis patients with
DM
.

Methods and Results

Using the National Health Insurance Research Database, we identified 17 760 patients with
DM
and new‐onset hemodialysis between 2001 and 2013. Of these, 1898 patients hospitalized for either ischemic or hemorrhagic stroke were matched to 7592 control patients according to sex, age, and year of initial hemodialysis therapy by using incidence sampling. The association between metformin use and stroke risk was estimated using conditional logistic regression after adjustment for hemodialysis frequency, comorbidity, and prescribed medications. Metformin use was recorded before the date of stroke admission and the date of pseudostroke of the case and control patients, respectively. Results showed that hemodialysis patients with ischemic stroke were more likely to use metformin than the controls 1 year before the date of stroke admission (adjusted odds ratio: 1.64; 95% confidence interval, 1.32–2.04). The association was evident within 90 days before the index date (adjusted odds ratio: 1.81; 95% confidence interval, 1.27–2.60). The results were consistent with those of hemodialysis patients with hemorrhagic stroke. Metformin use remained a risk factor for stroke in patients treated with antihypertensive, sulfonylurea, and antiplatelet drugs.

Conclusions

This nested case–control study is the first to show that metformin use is associated with stroke risk in hemodialysis patients with
DM
. We suggest that metformin should not be used by hemodialysis patients with
DM
.
Prolegomena to a Philosophical Phenomenology of Religion
Authors: Tuckett Jonathan 
Published: November 2017

AbstractThe aim of this paper is to deal with a slightly erroneous claim made in previous research that philosophical phenomenology has shown little interest in the topic of “religion”. The majority of this article deals with the branch of the Movement that I have dubbed Sociological Phenomenology which stems out of the work of Alfred Schutz and Max Scheler and has influenced scholars of religion like Peter Berger, Thomas Luckmann and James Spickard. I offer a Husserlian critique of this branch of phenomenology for failing to appreciate the key insights of his later phenomenology’s “ontological turn” where he turned to an analysis on the natural attitude and the life-world. I conclude by showing what a phenomenology or religion consistent with these later insights may look like.
Truth, Meaning, and the Study of Religion
Authors: Godlove Terry F. 
Published: November 2017

Abstract
This paper focuses on two contrasting approaches to the theory of linguistic meaning and asks how they color a range of issues of interest to scholars of religion. The so-called truth-conditional approach makes truth basic. It trades on the thought that we sometimes or perhaps often know what someone has said when we know what it would be for what she has said to be true. The other approach pegs meaning to how expressions and sentences are used in communicative situations. Dummett and Davidson are front and center. Davidson is of course in one sense a champion of truth-conditional semantics, but, over the issues I have in view, his case is instructively mixed. This discussion leads us toward an account of linguistic meaning which elevates over truth a family of concepts associated with use, including verification, justification, and pragmatic success.
Consonance and Communal Membership in the Didache
Authors: Campbell Warren C. 
Published: November 2017

Abstract
The Didache community reflects a group of Jewish Christ-devotees receiving both Jews and Gentiles into communal membership through the entrance pattern outlined in Did. 1-7. In light of Jewish and Gentile co-membership, the statement concerning Torah obedience in Did. 6:2-3, which promotes full Torah obedience and yet provides room for selective degrees of adherence for Gentile members, is a point of interest. Do the varying degrees of Torah adherence generate dissonance for the Jewish members? How is this apparent equanimity maintained? The argument advanced here is that since the ritual structure for communal entrance reflects conceptual and structural affinities with sectarian induction (1QS) and Rabbinic proselytism (b. Yeb 47a-b), the Jewish audience is able to draw associations between the ritual pattern used for the Didache community and wider Jewish processes for communal entrance. Did. 1-7 is then available as a resource to preserve consonance by providing a holistic association with a Jewish heritage.
Origen’s Vacillating Stances toward his “Valentinian” Colleague Heracleon
Authors: Berglund Carl Johan 
Published: November 2017

Abstract
When Origen of Alexandria presents numerous extensive quotations from Heracleon, whom he explicitly presents as a follower of Valentinus, one might expect a uniformly adversarial attitude toward this “Valentinian” sectarian. Instead, Origen’s stances are found to vacillate significantly from general renunciation and emphatic criticism, via considered disagreement and hypothetical approval, all the way to agreement and praise. The fascinating interplay between the stance taken and the dogmatic and philological matters in view implies that while dogmatic issues at stake are decisive for whether Origen agrees or disagrees with Heracleon, the full range of variance in Origen’s stances is determined by Heracleon’s philological methodology and presentation of evidence. Origen’s responses to Heracleon reveal that he viewed this predecessor not simply as a heterodox teacher, but also as a colleague in interpreting the New Testament using methods from Greco-Roman literary criticism.
Ancient Greek Tragedy Speaks to Democracy Theory
Authors: Saxonhouse Arlene W. 
Published: November 2017

Abstract
This essay initially distinguishes Athenian democracy from what I call ‘hyphenated-democracies’, each of which adds a conceptual framework developed in early modern Europe to the language of democracy: representative-democracy, liberal-democracy, constitutional-democracy, republican-democracy. These hyphenated-democracies emphasize the restraints placed on the power of political authorities. In contrast, Athenian democracy with the people ruling over themselves rested on the fundamental principle of equality rather than the limitations placed on that rule. However, equality as the defining normative principle of democracy raises its own problems, namely: How do we – of limited vision – identify who is equal, and what injustices attend the criteria used to establish who is equal? Consideration of several ancient tragedies illustrates how the Athenian playwrights explored these questions and how they identified the challenges faced by those who understand democracy as grounded on egalitarian principles.
Sophocles and Democracy
Authors: Sommerstein Alan H. 
Published: November 2017

Abstract
Sophocles was both a great dramatist and a significant figure in Athenian public life. As a public figure, he was elected to important offices by the Athenian demos, but he also had a hand in the abolition of democracy in 411 bc – and then won first prize in the first tragic contest held after democracy was restored. As a dramatist, he frequently gives the impression that the common people are helpless without strong and wise leadership; but he can also suggest that a leader is worth nothing if he neglects his people or ignores their opinions, and in Antigone he seems to go out of his way to highlight the importance of the opinion of the ordinary man as well as that of the elite.
Democracy’s Humility: A Reading of Sophocles’ Antigone
Authors: Kierstead James 
Published: November 2017

Abstract
Hegelian readings of Antigone would have us believe that Creon and Antigone are both heroes and villains at once. In this essay, I argue that Creon is in fact the villain of the piece, and a paradigmatic tyrant. Far from representing democratic rationalism, Creon is in fact the antitype of the epistemic humility that was one of the foundational ideals of Athenian democracy. As the Ode to Man and Protagoras’ Great Speech in Plato’s dialogue both suggest, human expertise ultimately reaches its limits in the sphere of ethics, an area overseen by the gods. For both Protagoras and Sophocles, in my reconstruction, democratic and religious practices are not an arrogant attempt to deny this fact, but a way of humbly accepting it. Through the humbling of Creon and the piety and reasonableness of Teiresias, Haimon, and even the Guard, Antigone illustrates an essential characteristic of democracy: its humility.
Restoring and Overturning Athenian Democracy in Aristophanes: Paradigmatic Truths and ‘Carnival’ Reversals
Authors: Sonnino Maurizio 
Published: November 2017

Abstract
The two historical examples used by Lysistrata in her peace speech (Ar. Lys. 1137-1156) are not comical distortions, but, just as in actual assembly orations, they rather represent a characteristic ‘modulation du paradigme’, according to which the examples are adapted to support the orator’s objective. The aim of Lysistrata’s speech, in particular, is to enable a shift from the upside-down world of gynecocracy that she herself established, to a full restoration of democratic Athens. Quite different is the situation in Ecclesiazusai, where the upside-down world created by Praxagora is an anti-democratic state from which it is impossible to return. It seems necessary to distinguish Aristophanes’ older dramas in which the subverted society returns to normal democracy, from his later works (Ecclesiazusai, Plutus), the only ones in which the overturning is permanent.
New species of Xiphoniscus and new record of Androdeloscia escalonai (Isopoda, Scutocoxifera, Oniscidea, Philosciidae) from Brazilian Amazon
Authors: GRANGEIRO DANIELA C. , SOUZA LEILA A. , CHRISTOFFERSEN MARTIN L. 
Published: November 2017

A new species in the previously monotypic genus Xiphoniscus Vandel, 1968, X. adisi sp. nov. is described. Both X. mirabilis Vandel, 1968 from Ecuador and X. adisi sp. nov. from Brazil occur in the Amazon rainforest. The new species shows a prolonged coxal plate II drawn out caudally, an autapomorphy of Xiphoniscus. Xiphoniscus adisi sp. nov. differs from X. mirabilis mainly in the characteristics of buccal appendages and male pleopods. A diagnosis of the genus Xiphoniscus is provided. The species Androdeloscia escalonai is reported from the Brazilian Amazon for the first time.
Migraine triggers and habituation of visual evoked potentials
Authors: Lisicki Marco , Ruiz-Romagnoli Emiliano , Piedrabuena Raúl , Giobellina Roberto , Schoenen Jean , Magis Delphine 
Published: November 2017

Background Identifying specific subsets of patients within the clinical spectrum of migraine could help in personalizing migraine treatment. Profiling patients by combining clinical characteristics and neurophysiological biomarkers is largely unexplored. We studied the association between migraine attack triggers and habituation of visual evoked potentials. Methods We personally interviewed 25 patients about their migraine triggers following a structured list, and measured the N1-P1 habituation slope over six blocks of 100 averaged pattern-reversal VEP afterwards. Results The mean number of triggers per patient was 4.52 ± 1.42. Habituation slopes differed significantly between subjects who reported stress as a migraine trigger (deficient VEP habituation) and subjects who did not (preserved VEP habituation). For the remaining categories, the mean amplitude slope was always positive, indicating deficient habituation, and was not significantly different between subgroups. Conclusions Migraine patients not reporting perceived stress as a trigger for their attacks might constitute a distinct clinic-physiological subset within the migraine spectrum.
Decline of Physical Activity in Terminally Ill Patients Could Be Useful for Predicting Short-Term Survival
Authors: Yasui Hiroki , Iwase Satoru , Ariyoshi Keisuke , Nojima Masanori , Yoshiuchi Kazuhiro 
Published: November 2017

Background: Although it is recommended that all terminally ill patients receive advance care planning (ACP), this is occasionally challenging because of the difficulty in predicting survival. There are some indexes for predicting survival, but few are accurate, especially at the terminal stages of illness. Methods: Twenty-two patients at the terminal stages of cancer were retrospectively analyzed. We assessed their physical activity and condition using activities of daily living (ADL) scores for 1 month before the death. The ADL scores included 7 items: walking, bathing, grooming, dressing, eating, transferring, and toileting. Results: Survival time after the first decline of physical activity was calculated (median: 13 days, 95% confidence interval [95% CI]: 5.6-20.4 days). Survival time after the second (median: 5 days, 95% CI: 0-10.9 days), third (median: 5 days, 95% CI: 0-13.4 days), and fourth (median time: 1 day, 95% CI: not applicable due to small size) decline of physical activity was also calculated. Conclusion: Change in physical activity seems helpful for estimating survival time, especially at the end of life, and this index could be useful for coordinating final ACP.