bluuebunny/crossref_metadata_2025_split huggingface dataset:
BLINDHEIT UND TAKT IN GOETHES WAHLVERWANDTSCHAFTEN
Authors: Torra‐Mattenklott Caroline 
Published: September 2017

ABSTRACTIn the eighteenth century, the German word ‘Takt’, in the first instance a synonym for the sense of touch and a musical term, adopts the figurative meaning of psychological and aesthetic sensitivity. Within a few decades, ‘tact’ then turns into a philosophical term for an intuitive form of empirical judgement that comes to bear in social intercourse as well as in the arts and sciences. In Goethe's novel Die Wahlverwandtschaften tact is a property of the female characters Charlotte and Ottilie, in whose actions it manifests itself literally as a sense of touch and rhythm. Aesthetic sensitivity, however, is not sufficient to hinder the fatal course of events: in Die Wahlverwandtschaften, tact is inseparably tied to blindness.
Review: A Japanese population‐based meta‐analysis of vonoprazan versus PPI for Helicobacter pylori eradication therapy: Is superiority an illusion?
Authors: Dong Shou Quan , Singh Tikka Prabhjot , Wei Xin , Yao Huang , Wang Hong Ling 
Published: September 2017

AbstractBackgroundVonoprazan (VPZ) is a novel acid suppressant that has been used in Helicobacter pylori (H. pylori) eradication therapies in recent years. However, the efficacy and safety of VPZ vs proton‐pump inhibitor (PPI) in H. pylori eradication therapies remain controversial.ObjectiveTo perform a meta‐analysis in order to assess the efficacy and safety of VPZ vs PPI for H. pylori eradication.Materials and MethodsThe PubMed, EMBASE, and Cochrane Library databases were searched up to July 10, 2017, for relevant randomized controlled trials (RCTs) and nonrandomized clinical studies (NRCTs). The pooled eradication rate (ER) and pooled occurrence rates of adverse events were used to compare the efficacy and safety of VPZ ‐ and PPI‐containing regimens.ResultA total of 14 studies with 14 636 patients were included in this meta‐analysis. The results showed that the pooled ER of VPZ ‐containing regimens was much higher than that of PPI‐containing regimens when used as first‐line therapies. This difference was significant for both intention‐to‐treat (85.1% vs 68.0%, P < .00001) and per‐protocol analyses (89.0% vs 74.2%, P < .00001). Moreover, subgroup analysis indicated significant superiority of VPZ in both patients with clarithromycin‐resistant strains (81.5% vs 40.9%, P < .00001) and those with clarithromycin‐susceptible strains (94.9% vs 89.6%, P = .006). However, VPZ did not show superiority to PPI as part of a second‐line triple therapy based on both intention‐to‐treat (83.4% vs 82.0%, P = .79) and per‐protocol analyses (89.3% vs 90.1%, P = .06). Finally, RCT subgroup analysis showed the safety of VPZ ‐containing regimens to be better than PPI‐containing regimens (26.4% vs 33.3%, P = .008), whereas there was no significant difference in this regard for the NRCT subgroup analysis (5.7% vs 4.7%, P = .08).ConclusionsThe efficacy of VPZ is superior to PPI in first‐line H. pylori triple eradication therapies but not in second‐line therapies. The safety of VPZ ‐containing regimens appears to be equal or even superior to that of PPI. However, most reports included in this study had low levels of evidence. Hence, adequate and high‐quality RCTs will be needed to support our results.
The concept of consumer vulnerability: Scale development and validation
Authors: Shi Hua Yu , Jing Feng Jie , Yang Yan , Nguyen Bang 
Published: September 2017

AbstractAlthough studies of nonrational consumer behaviour in the fields of psychology and marketing are widespread, few scholars have discussed this issue from the integrated perspective of individual characteristics and consumer welfare. Extant research has introduced the concept of consumer vulnerability to deepen the study of nonrational behaviour. The present research defines consumer vulnerability as an individual characteristic, that is, a tendency to be influenced by an external stimulation or temptation that leads to decisions harmful to the person's own welfare. To operationalize this concept, this study develops a consumer vulnerability scale. Results from exploratory factor analysis and confirmatory factor analysis reveal the following seven dimensions of consumer vulnerability: product knowledge, product promotion, marketing and emotional stress, social pressure, purchasing power, refunds policy and discrimination ability. After verifying the scale's reliability and validity, this study confirms that it can be applied to measure the degree to which consumer welfare has been harmed and predict nonrational decision‐making behaviour. Limitations and future research directions also are discussed.
Control of Staphylococcus aureus on soya bean products by D‐amino acids/nutmeg essential oil‐co‐loaded nanofilms
Authors: Cui Haiying , Yuan Lu , Li Changzhu , Lin Lin 
Published: September 2017

SummaryIn this present work, to minimise the risk of contamination by biofilm of Staphylococcus aureus (S. aureus), D‐amino acid (D‐AA) and nutmeg essential oil (NEO) were used to synergistically eliminate S. aureus biofilm formation. Chitosan nanoparticles (CNPs) were introduced to encapsulate D‐Pro, D‐Phe and NEO for getting better chemical stability during processing and storage. The optimal D‐AA/NEO@CNPs possessed high stability (particle size 155.3 nm, zeta potential 42.2 mV), high uniformity (polydispersity index 0.267) and superior antibiofilm performance. Then, for the application in soya bean products, electrospun nanofibrous membranes were introduced to immobilise the D‐AA/NEO@CNPs. And the antibiofilm assay of D‐AA/NEO@CNP‐loaded nanofibrous membranes exhibited excellent antibiofilm activity on soya bean products in this study.
Rheological properties of Colombian‐Caribbean‐coast sour cream from goat milk
Authors: Tirado Diego F. , Vertel‐Gallego Armando , Lora‐Sánchez José , Gallo‐García Luis Alberto , Acevedo Diofanor , Torres‐Gallo Ramiro 
Published: September 2017

SummaryThe viscoelastic properties provide guidelines to help give meaning to the observations on food products, to relate them to the way in which their structures behave, and to predict or modify their properties. This study analyses the incidence of varying the initial fat content of goat milk on the rheological properties of prepared sour cream. Storage (G′) and loss modulus (G″), as well as complex viscosity (η*) and loss factor values (tan δ), were determined at different initial fat contents in goat milk (3.75%, 4.00% and 4.25%). The experimental data were adapted to Maxwell model. All the prepared samples of sour cream meet national and international microbiological standards, and the initial fat content of goat milk influenced the viscoelastic behaviour of sour cream. Structures with prevalent elastic (G′) behaviour were found, and the product that was prepared from goat milk with 4.00% fat content showed the highest elastic modules. This sour cream exhibited higher firmness and better adherence when compared to the samples that were obtained from 3.75% and 4.25% fat‐content milk. This sample also exhibited the lowest tangent of the phase angle. Sour cream that was prepared from milk with higher fat content (4.00% and 4.25%) exhibited a semi‐solid behaviour along the entire temperature range that was studied. On the contrary, rheological properties of sour cream from 3.75% fat‐content milk tend to increase at temperatures above 333.15 K. The viscoelastic behaviour of sour cream was successfully explained under Maxwell model, while data from dynamic viscosity (η′) were adapted to Arrhenius model. Microstructure analysis to the sample considered as the best (from milk with 4.00% of initial fat content) showed that the protein network presented a rough, open surface with aggregates and wide spaces.
Optimal Adaptive Designs with Inverse Ordinary Differential Equations
Authors: Demidenko Eugene 
Published: September 2017

SummaryMany industrial and engineering applications are built on the basis of differential equations. In some cases, parameters of these equations are not known and are estimated from measurements leading to an inverse problem. Unlike many other papers, we suggest to construct new designs in the adaptive fashion ‘on the go’ using the A‐optimality criterion. This approach is demonstrated on determination of optimal locations of measurements and temperature sensors in several engineering applications: (1) determination of the optimal location to measure the height of a hanging wire in order to estimate the sagging parameter with minimum variance (toy example), (2) adaptive determination of optimal locations of temperature sensors in a one‐dimensional inverse heat transfer problem and (3) adaptive design in the framework of a one‐dimensional diffusion problem when the solution is found numerically using the finite difference approach. In all these problems, statistical criteria for parameter identification and optimal design of experiments are applied. Statistical simulations confirm that estimates derived from the adaptive optimal design converge to the true parameter values with minimum sum of variances when the number of measurements increases. We deliberately chose technically uncomplicated industrial problems to transparently introduce principal ideas of statistical adaptive design.
How to Finance the Rising Costs of Long‐Term Care: Four Alternatives for the Netherlands
Authors: Wouterse Bram , Smid Bert 
Published: September 2017

AbstractLong‐term care expenditures in the Netherlands have risen substantially over the last 40 years. Only a part of this growth can be attributed to the ageing of the population. Rising long‐term care costs threaten the sustainability of Dutch public finances: additional public revenues are needed to cover the additional spending. In this paper, we evaluate four alternative policies to finance the anticipated additional growth in long‐term care above the rate implied by projected demographic growth. We analyse these financing alternatives using a macro model, focusing on the long‐term effects on economic growth and on the redistribution of costs and benefits between birth cohorts. We find a relatively large intergenerational redistribution of lifetime net benefits for a pay‐as‐you‐go system and for an immediate one‐time increase of the premium rate, while a cohort‐specific savings system or a pensioner tax both have relatively small intergenerational effects. Labour supply and private consumption decline in all four financing alternatives, although the size and timing of these effects differ.
Does the Expansion of Public Long‐Term Care Funding Affect Saving Behaviour?
Authors: Costa‐Font Joan , Vilaplana‐Prieto Cristina 
Published: September 2017

AbstractWe study the effect of further public caregiving subsidies (and expansions of insurance to cover long‐term care) on savings and saving behaviour. Specifically, we examine the unique progressive introduction of a universal public long‐term care subsidy (Sistema para la Autonomía y Atención a la Dependencia, SAAD) in Spain. We draw on a difference‐in‐difference (DID) strategy to show a contraction of savings after the policy intervention, but only among younger elders who receive primarily cash benefits (unconditional caregiving allowance) as opposed to home help (a contraction ranging between 13 per cent and 39 per cent of the subsidy amount). Reductions in savings by individuals in the second and third quintiles of the income distribution, those aged under 75, those without children and those residing in regions that implemented the reform earlier drive the effect.
The Association Between the Use of Zolpidem and the Risk of Alzheimer's Disease Among Older People
Authors: Cheng Hui‐Ting , Lin Fang‐Ju , Erickson Steven R. , Hong Jin‐Liern , Wu Chung‐Hsuen 
Published: September 2017

ObjectivesTo evaluate the association between zolpidem use and the risk of Alzheimer's disease among older people.DesignA retrospective cohort study using data from 2001 to 2011 from the National Health Insurance Research Database.SettingTaiwan.ParticipantsA total of 6,922 patients aged 65 years or older enrolled from January 2002 to December 2004 (the enrollment period).Intervention (Exposure)Zolpidem users were identified as patients who used zolpidem during the enrollment period. The index date was the date of the first zolpidem prescription. Dosage of zolpidem use was defined using cumulative defined daily dose (cDDD) based on the cumulative dosage that patients took within one year after the index date (grouped as: less than 28, 28–90, 91–180, and more than 180 cDDD).MeasurementsThe occurrence of Alzheimer's disease was defined as the time period from the end of one year after the index date to the date of the Alzheimer's disease diagnosis. The propensity score was used to adjust the measured confounders of Alzheimer's disease. Cox proportional hazards models were used to evaluate the association between zolpidem use and the incidence of Alzheimer's disease.ResultsZolpidem users with a high cumulative dose (>180 cDDD) in the first year after initiation had a significantly greater risk of Alzheimer's disease than non‐zolpidem users (HR = 2.97, 95% CI = 1.61–5.49) and low cumulative dose (<28 cDDD) users (HR = 4.18, 95% CI = 1.77–9.86).ConclusionWe found the use of a high cumulative dose of zolpidem was associated with an increased risk of Alzheimer's disease among older people living in Taiwan. It is advised to use caution when considering long‐term use of zolpidem in older patients.
A three‐dimensional statistical model for imaged microstructures of porous polymer films
Authors: BARMAN S. , BOLIN D. 
Published: September 2017

SummaryA thresholded Gaussian random field model is developed for the microstructure of porous materials. Defining the random field as a solution to stochastic partial differential equation allows for flexible modelling of nonstationarities in the material and facilitates computationally efficient methods for simulation and model fitting. A Markov Chain Monte Carlo algorithm is developed and used to fit the model to three‐dimensional confocal laser scanning microscopy images. The methods are applied to study a porous ethylcellulose/hydroxypropylcellulose polymer blend that is used as a coating to control drug release from pharmaceutical tablets. The aim is to investigate how mass transport through the material depends on the microstructure. We derive a number of goodness‐of‐fit measures based on numerically calculated diffusion through the material. These are used in combination with measures that characterize the geometry of the pore structure to assess model fit. The model is found to fit stationary parts of the material well.
Paediatric food‐induced anaphylaxis hospital presentations in New Zealand
Authors: Speakman Sophie , Kool Bridget , Sinclair Jan , Fitzharris Penny 
Published: September 2017

AimGlobally, rates of paediatric food‐induced anaphylaxis (FIA) are increasing. Little data is available regarding the epidemiology of FIA among New Zealand (NZ) children. This study investigated the incidence of paediatric (0–14 years) FIA hospital presentations in NZ over a 10‐year period.MethodsMinistry of Health public hospital discharge data from 2006 to 2015 were analysed using FIA‐related International Classification of Diseases codes (T78.0 – anaphylactic shock due to adverse food reaction and T78.2 – anaphylactic shock unspecified and free text qualifier) to identify acute hospital presentations.ResultsThe overall annualised FIA hospital presentation rate was 16.2 per 100 000 children. Subgroup analysis indicated a significantly higher rate in males (19.1/100 000) than in females (13.1/100 000), and among children aged less than 2 years of age (50.5/100 000) compared with older children. Rates among Asian and Pacific children were higher than Māori and NZ European children. In 67.7% of cases, a single specific allergen was suggested by the information provided; among these cases, nuts (48%), specifically peanuts (26%), were the most commonly reported allergen, followed by cow's milk (21%). Time trend analysis showed a 2.8‐fold increase in the overall annualised rate for the 10‐year period.ConclusionThese findings are consistent with other international studies indicating increasing rates of FIA in children. These data will provide information for a review of NZ paediatric allergy services to ensure current international standards with regard to the equitable delivery of timely, appropriate and accessible care are being met. Reasons for differences by gender, age and ethnicity require further investigation.
Thermal evolution of trans‐Neptunian objects, icy satellites, and minor icy planets in the early solar system
Authors: Bhatia Gurpreet Kaur , Sahijpal Sandeep 
Published: September 2017

AbstractNumerical simulations are performed to understand the early thermal evolution and planetary scale differentiation of icy bodies with the radii in the range of 100–2500 km. These icy bodies include trans‐Neptunian objects, minor icy planets (e.g., Ceres, Pluto); the icy satellites of Jupiter, Saturn, Uranus, and Neptune; and probably the icy‐rocky cores of these planets. The decay energy of the radionuclides, 26Al, 60Fe, 40K, 235U, 238U, and 232Th, along with the impact‐induced heating during the accretion of icy bodies were taken into account to thermally evolve these planetary bodies. The simulations were performed for a wide range of initial ice and rock (dust) mass fractions of the icy bodies. Three distinct accretion scenarios were used. The sinking of the rock mass fraction in primitive water oceans produced by the substantial melting of ice could lead to planetary scale differentiation with the formation of a rocky core that is surrounded by a water ocean and an icy crust within the initial tens of millions of years of the solar system in case the planetary bodies accreted prior to the substantial decay of 26Al. However, over the course of billions of years, the heat produced due to 40K, 235U, 238U, and 232Th could have raised the temperature of the interiors of the icy bodies to the melting point of iron and silicates, thereby leading to the formation of an iron core. Our simulations indicate the presence of an iron core even at the center of icy bodies with radii ≥500 km for different ice mass fractions.
Granulomatosis with Polyangiitis Presenting with Pyoderma Gangrenosum–Like Ulceration and Negative Cytoplasmic Antineutrophilic Cytoplasmic Antibodies in a Child
Authors: Kass Ashley , Fagan Jake D. , Long Paul 
Published: September 2017

AbstractGranulomatosis with polyangiitis (GPA), a vasculitis that most commonly affects small to medium‐size vessels of the respiratory tract and kidneys, may also present with a wide array of skin findings. We present the case of a 12‐year‐old boy with pyoderma gangrenosum–like ulcerations on his lower extremity as the initial manifestation of GPA despite negative cytoplasmic antineutrophilic cytoplasmic antibodies (c‐ANCAs). Although GPA is strongly associated with c‐ANCA, c‐ANCA may be negative on presentation. Thus clinical and pathologic clues must be relied upon when serologic confirmation is negative.
Shedding Light on Alopecia Areata in Pediatrics: A Retrospective Analysis of Comorbidities in Children in the National Alopecia Areata Registry
Authors: Sorrell Jennifer , Petukhova Lynn , Reingold Rachel , Christiano Angela , Garzon Maria 
Published: September 2017

AbstractAlopecia areata (AA) is a common autoimmune disease and it is challenging to predict which patients will have severe disease. The purpose of this retrospective study was to identify comorbidities in children enrolled in the National Alopecia Areata Registry. Atopic dermatitis was more common in patients with severe AA than in those with mild disease. The most common autoimmune comorbidities were vitiligo, psoriasis, thyroid disease, and juvenile idiopathic arthritis.
Adams–Oliver Syndrome Type 2 in Association with Compound Heterozygous DOCK6 Mutations
Authors: Jones Krystal M. , Silfvast‐Kaiser Annika , Leake David R. , Diaz Lucia Z. , Levy Moise L. 
Published: September 2017

AbstractAdams–Oliver syndrome (AOS) is a multiple congenital anomaly syndrome characterized by aplasia cutis congenita (ACC) and transverse terminal limb defects (TTLDs). We present a case of type 2 autosomal recessive AOS associated with heterozygous mutations in the dedicator of cytokinesis 6 (DOCK6) gene, with characteristic findings of ACC, TTLD, intracerebral periventricular calcifications, and polymicrogyria.
The Use of Framing in Inventory Decisions
Authors: Schultz Kenneth L. , Robinson Lawrence W. , Thomas L. Joseph , Schultz Johnathon , McClain John O. 
Published: September 2017

It is well established that human newsvendors tend to order insufficient inventory in high‐margin situations, possibly due to implicit risk aversion. In this study, we investigate the use of framing to change newsvendors’ risk preference in order to induce them to make better ordering decisions. Through an exploratory experiment and five different treatments of the newsvendor problem, we found risk reversal only in the treatments with one question. In the other four treatments and the exploratory experiment, we asked multiple questions and found no evidence of risk reversal. Thus, we conclude that risk reversal cannot reliably be used without pretesting and that behavioral theories need to be tested in context. Finally, we reaffirm research showing that relying on averages can mask the heterogeneity of human decision‐making.
The effect of expressive writing on the error‐related negativity among individuals with chronic worry
Authors: Schroder Hans S. , Moran Tim P. , Moser Jason S. 
Published: September 2017

AbstractThe error‐related negativity (ERN), an ERP elicited immediately after errors, is enlarged among individuals with anxiety. The relationship between anxiety and enlarged ERN has spurred interest in understanding potential therapeutic benefits of decreasing its amplitude within anxious individuals. The current study used a tailored intervention—expressive writing—in an attempt to reduce the ERN among a sample of individuals with chronic worry. Consistent with hypotheses, the ERN was reduced in the expressive writing group compared to an unrelated writing control group. Findings provide experimental support that the ERN can be reduced among anxious individuals with tailored interventions. Expressive writing may serve to “offload” worries from working memory, therefore relieving the distracting effects of worry on cognition as reflected in a decreased ERN.