bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the outcomes of staging laparoscopy in intrahepatic cholangiocarcinoma patients undergoing surgical resection: a multicenter retrospective study in China
Authors: Qin Delong , Chen Jialu , Tang Yue , Li Zonglong , Geng Zhimin , Wu Hong , Qiu Yinghe , Song Tianqiang , Mao Xianhan , He Yu , Cheng Zhangjun , Zhai Wenlong , Li Jingdong , Liang Xiao , Lin Ruixin , Tang Di , Sun Chuandong , Tang Zhaohui 
Published: September 2024

Aim: To evaluate the perioperative outcomes and postoperative survival of applying staging laparoscopy (SL) in intrahepatic cholangiocarcinoma (ICC) patients undergoing surgical resection.
Methods: A retrospective analysis was performed on all selected ICC patients who underwent curative-intent resection with/without applying staging laparoscopy from January 2010 to August December 2021. Perioperative outcomes and postoperative survival were analyzed. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were performed to reduce the bias due to confounding variables in the SL group and the non-SL group. Multivariate Cox analysis was used to ascertain the independent predictor of survival for ICC patients.
Results: A total of 279 patients (24.1%) were included in the SL group, while 881 patients (75.9%) were included in the non-SL group. Compared with the non-SL group, the SL group had lower blood loss, smaller tumor size, higher R0 resection rate, and shorter hospital stay, but a higher incidence of postoperative complications. The OS of the SL group was better than that of the non-SL group (Median OS: 31 months vs. 20 months). The 1-, 3-, and 5-year overall survival rates of the SL group were 77.9%, 45.1%, and 32.9%, respectively, while the non-SL group had rates of 63.9%, 31.3%, and 18.4%. SL was confirmed as an independent predictor of survival by multivariate Cox analysis.
Conclusion: ICC patients receiving SL had better perioperative outcomes and significantly prolonged overall survival after resection surgery. The subgroup analysis results support the use of routine SL.
Analysing the Socio-Economic Conditions of Waste Pickers in Uttar Pradesh
Authors: Gagan Alka , Anand Subhash , Rani Usha , Kumar Ashwani , Dubey Anupama 
Published: September 2024

Waste pickers pick up reusable and recyclable waste from roadsides, dustbins, and landfills and sell it to local scrap dealers to earn money to fulfil their daily needs. Waste pickers do this in very unhygienic and hazardous conditions. This study examines the socio-economic status of waste pickers working in Ghaziabad using the Kuppuswamy SES (2020) scale. For this, 200 waste pickers, including male and female respondents, participated in this study. IBM SPSS software was used to code and analyse the data. Correlation matrix and regression were used for analysis. The research found that although waste pickers are crucial to society, their socio-economic situation is among the lowest. 51% of waste pickers are from the lower middle class, and 42% are from the upper lower class. These waste pickers of our study are underprivileged, illiterate, and live in poor conditions. For a sustainable and decent living, they need the government to satisfy some of their needs, including free medical services, access to clean, fresh water, social safety, and training for alternative employment.
KEBIJAKAN BANK BTN KANTOR CABANG SOLO MEMBERIKAN RELAKSASI KREDIT BAGI DEBITUR SAAT MASA PANDEMI COVID-19 (Studi Kasus di Bank Tabungan Negara Kantor Cabang Solo)
Authors: Shafira Deassy Prima , Pranoto ' 
Published: September 2024

<p align="center"><strong><em>Abstract</em></strong></p><p><em>This article aims to find out the policies used by Bank BTN Solo Branch Office in providing credit relaxation for debtors during the COVID-19 pandemic. This research is empirical legal research and descriptive-analytical. The approach used in this study is qualitative approach. The type of data used is primary data derived from informant interviews at BTN Solo Branch Office as well as secondary data derived from the study of primary and secondary legal materials that use download and copy techniques and then collect, categorize and qualify primary and secondary legal materials as needed based on research objects. The technique of legal material analysis in this study uses sociological/teleological interpretation, systematic interpretation, and uses interactive analysis model. Legal problems arising in number 2 the points of regulation of POJK No. 11/POJK.03/2020 concerning National Economic Stimulus as a Countercyclical Policy on the Impact of the Spread of COVID-19 there is the word "can" which means not obliging banks to implement it, but giving the option to banks to implement or not relax credit based on these regulations in accordance with the policies of each bank. As a result, the policy was used by Bank BTN Solo Branch Office as a legal basis to provide credit relaxation for debtors affected by COVID-19. </em></p><p align="center"> </p>
KEABSAHAN PURCHASE ORDER BERBAHASA ASING SEBAGAI PERJANJIAN JUAL BELI BERDASARKAN UNDANG-UNDANG NOMOR 24 TAHUN 2009 TENTANG BENDERA, BAHASA, DAN LAMBANG NEGARA, SERTA LAGU KEBANGSAAN
Authors: Aditya Wibawa Faiz Rafii , Tuhana ' 
Published: September 2024

<p><em>This article describe, first, the validity of a foreign language purchase order as a sale and purchase agreement. Second, the legal consequences of violating Article 31 of Law Number 24 of 2009 concerning the Flag, Language and National Emblem, as well as the National Anthem. This type of article is normative that is prescriptive and applied. The type of data used is secondary data with primary and secondary legal materials, as well as non-legal materials or tertiary legal materials. Data collection techniques are carried out by downloading, copying, collecting and then reading, studying, reviewing and analyzing primary legal materials such as laws, Civil Code and other regulations, books, articles, journals related to the issues reviewed by the author. Furthermore, the technical analysis used is the deduction method. The study show that purchase order is a valid agreement in accordance with the valid terms of the agreement, then if the sale and purchase transaction is carried out with a foreign party and uses a purchase order to reach an understanding, the purchase order must be made in Indonesian then the equivalent is made with the national language of the foreign party country and/or English. Second, purchase orders that violate these provisions do not have a criminal sanction, but purchase order can be canceled or requested for cancellation.</em></p><p>Artikel ini mengkaji mengenai, pertama, keabsahan <em>Purchase Order</em> bahasa asing sebagai perjanjian jual beli. Kedua, akibat hukum dari pelanggaran Pasal 31 Undang-Undang Nomor 24 Tahun 2009 tentang Bendera, Bahasa, dan Lambang Negara, serta Lagu Kebangsaan. Jenis artikel ini adalah normatif yang bersifat preskriptif dan terapan. Jenis data yang digunakan adalah jenis data sekunder dengan bahan hukum primer dan sekunder, serta bahan non-hukum atau bahan hukum tersier. Teknik pengumpulan data dilakukan dengan cara mengunduh (download), meng-copy, mengoleksi lalu membaca, mempelajari, mengkaji dan menganalisis bahan-bahan hukum primer seperti Undang-Undang, Kitab Undang-Undang Hukum Perdata serta peraturan lain, buku-buku, artikel, jurnal yang berhubungan dengan isu yang dikaji. Selanjutnya teknis analisis yang digunakan adalah metode deduksi. Hasil dari penelitian menunjukan bahwa <em>purchase order</em> merupakan perjanjian yang sah sesuai dengan syarat sahnya perjanjian, lalu apabila transaksi jual beli dilakukan dengan pihak luar negeri dan menggunakan <em>purchase order</em> demi tercapai kesepahaman <em>purchase order</em> wajib dibuat dalam Bahasa Indonesia lalu dibuat padanannya dengan bahasa nasional dari pihak luar negeri dan/atau Bahasa Inggris. Yang kedua, <em>purchase order</em> yang melanggar ketentuan tersebut tidak terdapat sanksi secara pidana namun <em>purchase order</em> tersebut dapat dibatalkan atau dimintai pembatalan.</p>
The Influence of Perceived Ease of Use and Perceived Risk on Intention to Use through Trust as Intervening on the Use of ShopeePay
Authors: Rizka Nuranda Azaria 
Published: September 2024

This research aims to examine the factors that influence intention to use towards using ShopeePay. This type of research is quantitative research using survey methods through questionnaires that are distributed boldly and used population was ShopeePay users in DKI Jakarta within a total sample of 220 people. The analysis techniques used to process the collected data are validity and reliability tests with SPSS software and Structural Equation Modeling (SEM) tests with AMOS 24 software. Through these technical analysis techniques, the results show that all indicators are valid and reliable, as well as perceived ease of use has an positive effect on trust, perceived risk has no effect on trust, perceived ease of use and trust has an positive effect on intention to use, perceived risk has no effect on intention to use, perceived ease of use has positive effect on intention to use through trust, and perceived risk has no effect on intention to use through trust.

Keywords: Perceived Ease of Use, Perceived Risk, Trust, Intention to Use, ShopeePay
INSECT HERBIVORY ON FERNS FROM A MODERN MARSH LOWLAND LOCALITY, SOUTHERN BRAZIL: IMPLICATIONS FOR INTERPRETING FOSSIL PLANT–INSECT INTERACTIONS
Authors: CENCI ROMULO , HORODYSKI RODRIGO SCALISE 
Published: September 2024

Abstract
Ferns are a model plant group for comparing insect herbivory between modern and deep time assemblages. We assessed fern–arthropod interactions in a modern marsh to reveal the taphonomic, morphological, and ecological implications of insect herbivory on fossil plant assemblages. Six functional feeding groups—hole feeding, margin feeding, surface feeding, piercing and sucking, galling, and pathogens—are present in eight fern species. We identified a total of 23 distinct damage types (DTs) on ferns, comprising 16 insect-mediated DTs, two of which are newly described in this study, and seven pathogen DTs, including one new addition. Among these, we present six arthropod-induced DTs that were previously undocumented in ferns. Furthermore, we report five DTs with fossil analogs. External foliage feeding, consisting of hole feeding, margin feeding, and surface feeding functional feeding groups, is the principal factor for DT richness on ferns in this lowland locality. We found products of arthropods behavior on ferns, such as instar molts and dead bodies and the byproducts from reproductive processes, which are unlikely to preserve in the fossil record. The taphonomic implications of these arthropod behavioral products are inferred by considering the substances that attach these structures to leaf tissues, potentially enhancing their preservation potential in the fossil record. Relatively mesic conditions support ferns in the lowland locality, resulting in a greater richness of insect herbivory compared to ferns in cooler xeric habitats from a previously surveyed upland locality.
THROUGH FIRE, AND THROUGH WATER, AN ABUNDANCE OF MID-DEVONIAN CHARCOAL
Authors: GLASSPOOL IAN J. , GASTALDO ROBERT A. 
Published: September 2024

Abstract
Evidence of fire in the Middle Devonian remains globally scarce. Charcoalified mesofossils recovered from the Emsian–Eifelian Trout Valley and St. Froid Lake formations of Maine are direct evidence of wildfires proximal to the Acadian Orogen, formed as the Avalon terrane and the North American plate collided. These mesofossils include charred psilophytes, lycopsids, prototaxodioids, enigmatic taxa such as Spongiophyton, and coprolites. Here, fire combusted a senesced and partially decayed litter, and the intimately associated nematophytes, following a period of extended dryness. We envisage wildfires occurred during neap tide when exposure of the flora of this estuarine setting was prolonged. Herein we provide a reconstruction of this Middle Devonian landscape and its flora in which lightning generated by post-dry season storms ignited wildfires that propagated through an extensive psilophyte-dominated litter.
Climate Change Contributes to Loss of Wild Rice (Manoomin/Psiŋ), Threatening Indigenous Lifeways
Authors: Nyblade Madeline , Larkin Daniel , Vogt Darren , Croll Rob , Ng G.H. , Graveen Joe , Hansen Kristen , Panci Hannah , Byrne Brandon , Panek Bazile 
Published: September 2024

Abstract

Climate change threatens lifeways of Indigenous Peoples, impacting their rights to self-determination and sovereignty. In the Laurentian Great Lakes region, Indigenous communities have experienced declines of wild rice (Ojibwemowin: Manoomin; Dakodiapi: Psiŋ; Latin: Zizania palustris), a sacred plant central to their culture. Past studies have implicated climate change in these declines but without quantification. Leveraging long-term, large-scale monitoring data collected by tribal organizations, we analyzed wild rice density and harvest data in relation to key climate conditions expected to impair wild rice’s vulnerable early life stages. Our results indicate that wild rice available for tribal harvest off-reservations has declined regionally by ~ 5–7% annually and likely will continue in part due to anthropogenic climate change, specifically increased early summer precipitation and warmer winters with less snow and shorter ice-duration. This decline has infringed on Indigenous lifeways by reducing off-reservation tribal harvest, a right guaranteed by treaties with the US government.
Tannic Acid Attenuates Quinolinic Acid-Induced Neurodysfunction by Modulating Oxidative Stress Parameters and Electrogenic Pump Activity
Authors: Ale Ebenezer Morayo , Ayo Victoria Ifeoluwa , Asuelimen Steve Osagie , Timothy Mgbede Joy , Adewole Mulikat Adenike , Nathan Rimamsanati Yohanna 
Published: September 2024

Abstract

The pathophysiology of neurodegenerative illnesses is largely dependent on oxidative stress and poor ion homeostasis, and these conditions represent a substantial worldwide health burden. Endogenous neurotoxic quinolinic acid (QA) is linked to neurodysfunction by inducing oxidative stress and interfering with sodium pump function. In a number of models, the polyphenolic molecule tannic acid (TA), which has strong antioxidant qualities, has demonstrated pharmacological effects in several diseased conditions. However, the neuroprotective effect of TA is rather speculative and still very open for clarification. In the present study, an in vitro model was employed to examine the effect of TA on deoxyribose degradation, lipid peroxidation, thiol status, antioxidant enzymes and cerebral and spinal sodium pump in rat cerebral and spinal tissue homogenates treated with quinolinic acid (QA, 2 mM). Results revealed that QA treatment led to a profound (p < 0.05) degradation of deoxyribose, formation of thiobarbituric acid reactive substances (TBARS), and marked (p < 0.05) reduction in tissue level of free thiols. However, TA treatment significantly (p < 0.05), counteracted TBARS production, deoxyribose degradation and markedly (p < 0.05) increased the thiol level of the cerebral and spinal tissue homogenates. Furthermore, QA markedly (p < 0.05) diminished the activities of cerebral and spinal antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD), Glutathione Peroxidase (GPx) and Glutathione S transferase (GST)] and impaired the activities of cerebral and spinal sodium pump. Nonetheless, the activities of the antioxidant enzymes and pump were all raised in both the cerebral and spinal tissue homogenates upon TA treatment. These findings justify the pharmacological action of TA on QA-induced neurotoxicity and suggest its potential use in the treatment of neurodegenerative diseases. Further investigation is required to determine TA's translational usefulness in clinical settings.
Design &amp; Analysis of Multiple effect Evaporator for Sugar Industry
Authors: Sanadi Atulkmar. G. , Khot Sanjay A. 
Published: September 2024

Abstract

A number of process industries, including pulp and paper, sugar, desalination, pharmaceuticals, dairy and food processing, etc., have evaporators as one of their most energy-intensive components. If the heat from the vapour is not used, a single effect evaporator might be energy inefficient. Using multiple-effect evaporators solves this problem. Because Vapour bleeding is implemented, Robert type evaporators are typically regarded as the preferred evaporator design in the cane sugar industry. The three-effect evaporator system model that will be created for this project has three effects. The model includes vapour bleeding as a way to cut back on the amount of steam used in the evaporator. Using waste heat while lowering steam consumption and heating power are the goals of multiple effect arrangements. This is accomplished by employing the vapour produced in the first stage as the second stage's heat source and the third stage's heat source. Condensate, feed and product flashing, vapour compression, and other energy-saving techniques are also available. Vapour bleeding improves the process's steam economy, but at the increased expense of the necessary heat exchangers. Along with designing this evaporator, we will analyse data to identify various stresses and develop a support system to minimise the evaporator's weight. .
Measuring space charge and electric field in axisymmetric dielectric barrier discharge using EFISH technique
Authors: Park Jin , Cha Min Suk 
Published: September 2024

Abstract

We investigated the dynamic interactions between electric fields and space charges within an axisymmetric dielectric barrier discharge (DBD) configuration. Employing a square-wave AC, the DBD setup ensured spatial and temporal consistency in microdischarge occurrences. The Electric Field Induced Second Harmonic Generation (EFISH) technique was utilized to capture electric fields and space charge distributions, with special emphasis on the theoretical deduction of space charges from Gauss’s Law. After a microdischarge occurred, the measured electric fields diminished due to the destructive superposition of external electric fields and th fields induced by space charges. This reduction in electric field intensity prevented subsequent microdischarges from occurring. However, when the polarity changed, our results demonstrated an increase in the electric fields due to constructive reinforcement between the external electric fields and the space-charge-induced electric field. This enhancement in the electric field facilitated the occurrence of subsequent microdischarges. Notably, a dominant excess of negative charges was observed in the negative phase after the microdischarge, indicating a net negative-charge domain likely due to electron emission from a metallic electrode. This study confirmed the effectiveness of the proposed method for estimating space charges by showcasing the inherent operating mechanism of DBD.
Cytomorphological Changes of Oral Mucosal Cells Among Smokeless Tobacco Users in Low and Middle-Income Country Settings: Insights from Pakistan
Authors: Hassan Sabreen , Sifat Ayesha , Munib Muhammad , Saeed Saliha , Nisa Waqar U , Durrani Sofia Haider , Rahim Abid , Ullah Naeem , Afaq Saima , Khattak Farhad Ali , Haq Zia Ul 
Published: September 2024

Abstract

Background: Chronic tobacco use, in any form, induces significant cellular alterations in the oral mucosa. This study investigates four distinct cytomorphological changes in oral mucosal cells among smokeless tobacco users, examining their association across different genders and age groups.
Materials and methods: This cross-sectional study involved collecting mucosal samples from smokeless tobacco (naswar) users through consecutive sampling. The prepared smears were examined for dysplastic changes. Data analysis was performed using SPSS, with Chi-square tests and logistic regression employed to evaluate proportions and associations.
Results: Among 100 Naswar users, the labial sulcus mucosa was the most common site affected (47%). The most frequent cytomorphological change was micronuclei (46%), followed by nuclear budding (25%), perinuclear halo (18%), and binucleated cells (14%). In the 51-60 age group, micronuclei (78.9%), nuclear budding (55.3%), binucleation (31.6%), and perinuclear halo (36.8%) were more prevalent (P < 0.005). Gender analysis revealed that micronuclei were more common in females (54.2%) compared to males (43.4%), while nuclear budding was more prevalent in males (27.6%) than females (P < 0.28). Logistic regression indicated that individuals aged 51-60 were more likely to exhibit micronuclei (OR = 1.15, 95% CI: 0.22 to 5.83, P = 0.863) and nuclear budding (OR = 5.34, 95% CI: 9.23 to 30.75, P < 0.05).
Conclusion: The dysplastic changes observed included micronuclei, nuclear budding, binucleated cells, and perinuclear halo, with micronuclei being the most prevalent. These findings could facilitate the early diagnosis of oral lesions and their timely management in habitual smokeless tobacco users.
SPINK1 Facilitates Tumor Progression in OSCC: Insights from Single-cell RNA Sequencing
Authors: Bao Mingyan , Tang Zhangui 
Published: September 2024

Abstract

Objective This investigation aimed to delineate the role and underlying mechanism of Serine Peptidase Inhibitor Kazal Type 1 (SPINK1) in oral squamous cell carcinoma (OSCC) via single-cell RNA-seq data.Materials and Methods Subpopulations of OSCC cells were identified via the GEO database. Cell‒cell communication analysis, gene set variation analysis (GSVA), gene set enrichment analysis (GSEA), and miRNA network construction were used to evaluate the role of SPINK1 in OSCC. The expression profile of SPINK1 in OSCC was authenticated via immunohistochemistry, quantitative polymerase chain reaction (qPCR), and Western blotting. The tumorigenic propensity of SPINK1 was evaluated through overexpression and knockdown assays employing Cell Counting Kit-8 (CCK-8), scratch assays, and transwell assays.Results SPINK1 was closely associated with T cells, malignant cells, and an array of immune modulators, including chemokines and immunoinhibitors, throughout OSCC progression. SPINK1 operates through pathways involving P53 and WNT signalling cascades. Relative to their normal tissue counterparts, SPINK1 is upregulated in OSCC, resulting in increased cell proliferation, invasion, and migration upon SPINK1 overexpression, whereas SPINK1 knockdown has opposite effects.Conclusion SPINK1 has emerged as a promising therapeutic target for the management of OSCC, offering prospective avenues for tailored therapeutic interventions and precision medicine strategies.