bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autonomie et projet migratoire : deux notions abordées à travers les travaux d’Emmanuel Ma Mung
Authors: Polyzos Iris 
Published: May 2017

L’article s’articule autour de deux notions-clés pour l’étude des migrations internationales : le point de vue de l’autonomie comme approche théorique et la notion du projet migratoire comme approche épistémologique. Il ne tente pas de donner une définition de ces notions, mais essaie d’en retracer la généalogie et en particulier de montrer leurs évolutions à travers les objets de recherche qui ont préoccupé leur principal penseur et auteur, Emmanuel Ma Mung, entre les années 1970 et aujourd’hui. Durant cette période, le géographe a élaboré la notion d’autonomie à travers deux grands axes de recherche : la diaspora chinoise et l’entreprenariat ethnique. Depuis 1989, l’auteur est membre de l’équipe du laboratoire Migrinter, dont il a assuré sa direction entre 1995 et 2004.
Fossils and tombs and how they haunt us
Authors: Meylahn Johann-Albrecht 
Published: May 2017

Fossils and tombs in museums fascinate us and haunt us with their secrets. The discovery of the remains of Homo naledi, found, as argued by some, in an ancient burial chamber, promises to reveal secrets of an unremembered past, thus offering clues concerning our present-day humans and maybe influence our human future. The paper will not engage directly with what Homo naledi might contribute to the various science-religion and/or theology conversations but rather engage with the grammars of these conversations, by asking the question, why do tombs and fossils haunt us? This article will bring into the conversation Derrida’s interpretation on tombs and fossils, his hauntology, as well as the fascination with secrets. It will not offer an interpretation of Naledi, but rather ask the question why she inspires (haunts) the belief that she has something to offer the science-religion conversation (which I believe she does), or why she inspires the belief that such discoveries make no difference to the religious views on creation, for example. Whichever way, the dead, and specifically those dead to human memory, when ‘recalled’, haunt us and disturb us with their secrets.
Touching The Human Neuron: User-Centric Augmented Reality Viewing and Interaction of in-vivo Cellular Confocal Laser Scanning Microscopy (CLSM) Utilizing High Resolution zStack Data Sets
Authors: Riddle Scott , Wasser Daniel , McCarthy Michael 
Published: May 2017

This is the first report of a prototype that allows for real-time interaction with high-resolution cellular modules using GLASS© technology. The prototype was developed* using zStack data sets which allow for real-time interaction of low polygon and direct surface models exported from primary source imaging. This paper also discusses potential educational and clinical applications of a wearable, interactive, user-centric, augmented reality visualization of cellular structures.
Full article title: Touching The Human Neuron: User-Centric Augmented Reality Viewing and Interaction of in-vivo Cellular Confocal Laser Scanning Microscopy (CLSM) Utilizing High Resolution zStack Data Sets for Applications in Medical Education and Clinical Medicine Using GLASS and Motion Tracking Technology
Medial Hip Arthroscopy Portals: A Novel Approach for Hip Pathologies. is it Feasible?
Authors: Polesello Giancarlo C. , Queiroz Marcelo C. , de Figueiredo Marina J.P.S.S. , Braga Susana R. , Ricioli Walter , Akkari Miguel 
Published: May 2017

Purpose To report 3 patients operated on using medial hip arthroscopic portals, describe the surgical technique and clinical outcomes. Methods Three medial portals were made, the first one at the posterior edge of the adductor longus muscle (posterior medial portal), the second one at the anterior (anterior medial portal) and the third at the posterior border of the adductor longus, 5 cm distal to the inguinal crease (distal posterior medial portal). The first case was an 8-year-old boy with a lytic lesion at the posteromedial region of the femoral neck suggestive of sub-acute osteomyelitis. The second patient was a 21-year-old male with a posteromedial femoral neck nidus. The third patient was a 42-year-old male with a posteromedial femoral neck cystic lesion. Conclusions The described portals allowed successful access to posteromedial femoral neck. There were no neurovascular lesions, infection, femoral head osteonecrosis, skin retraction or functional limitation related to the portals.
Concordance analysis between HER2 immunohistochemistry and in situ hybridization in non-small cell lung cancer
Authors: Ko Young San , Kim Nae Yu , Pyo Jung-Soo 
Published: May 2017

Purpose: This study aimed to elucidate the concordance between human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) and in situ hybridization (ISH) and the diagnostic accuracy of HER2 IHC in non-small cell lung cancer (NSCLC) through a meta-analysis and diagnostic test accuracy review. Methods: Seven eligible studies and 1,217 patients with NSCLC were included in the review. The concordance between HER2 IHC and ISH was analyzed. To confirm the diagnostic accuracy of HER2 IHC, the sensitivity and specificity were analyzed and the area under the curve (AUC) in the summary receiver operating characteristic (SROC) curve was calculated. Results: The concordance rate between HER2 IHC and ISH was 0.795 (95% confidence interval [CI] 0.534-0.929). In the HER2 IHC-negative (score 0/1+) subgroup, the concordance rate was 0.975 (95% CI 0.854-0.996). The concordance rates of the HER2 IHC score 2+ and 3+ subgroups were 0.091 (95% CI 0.039-0.197) and 0.665 (95% CI 0.446-0.830), respectively. In diagnostic test accuracy review, the pooled sensitivity and specificity were 0.67 (95% CI 0.54-0.78) and 0.89 (95% CI 0.87-0.91), respectively. The AUC in the SROC curve was 0.891 and the diagnostic odds ratio was 16.99 (95% CI 5.08-56.76). Conclusions: HER2 IHC was largely in agreement with ISH in cases of HER2 IHC score 0/1+. Because the concordance rates of HER2 IHC score 2/3+ cases were lower than that of HER2 IHC score 0/1+ cases, further studies for detailed analysis criteria for HER2 IHC score 2+ or 3+ are required.
Effect of Low-Intensity Pulsed Ultrasound on Osteogenic Human Mesenchymal Stem Cells Commitment in a New Bone Scaffold
Authors: Carina Valeria , Costa Viviana , Raimondi Lavinia , Pagani Stefania , Sartori Maria , Figallo Elisa , Setti Stefania , Alessandro Riccardo , Fini Milena , Giavaresi Gianluca 
Published: May 2017

Purpose Bone tissue engineering is helpful in finding alternatives to overcome surgery limitations. Bone growth and repair are under the control of biochemical and mechanical signals; therefore, in recent years several approaches to improve bone regeneration have been evaluated. Osteo-inductive biomaterials, stem cells, specific growth factors and biophysical stimuli are among those. The aim of the present study was to evaluate if low-intensity pulsed ultrasound stimulation (LIPUS) treatment would improve the colonization of an MgHA/Coll hybrid composite scaffold by human mesenchymal stem cells (hMSCs) and their osteogenic differentiation. LIPUS stimulation was applied to hMSCs cultured on MgHA/Coll hybrid composite scaffold in osteogenic medium, mimicking the microenvironment of a bone fracture. Methods hMSCs were seeded on MgHA/Coll hybrid composite scaffold in an osteo-inductive medium and exposed to LIPUS treatment for 20 min/day for different experimental times (7 days, 14 days). The investigation was focused on (i) the improvement of hMSCs to colonize the MgHA/Coll hybrid composite scaffold by LIPUS, in terms of cell viability and ultrastructural analysis; (ii) the activation of MAPK/ERK, osteogenic ( ALPL, COL1A1, BGLAP, SPP1) and angiogenetic ( VEGF, IL8) pathways, through gene expression and protein release analysis, after LIPUS stimuli. Results LIPUS exposure improved MgHA/Coll hybrid composite scaffold colonization and induced in vitro osteogenic differentiation of hMSCs seeded on the scaffold. Conclusions This work shows that the combined use of new biomimetic osteo-inductive composite and LIPUS treatment could be a useful therapeutic approach in order to accelerate bone regeneration pathways.
A Direct Assay for Measuring Free 25-Hydroxyvitamin D
Authors: Heureux Nicolas , Lindhout Ernst , Swinkels Leon 
Published: May 2017

Abstract
Recent studies suggest that the concentration andgenotype of vitamin D binding protein (VDBP) are important factors that determine the bioavailability of25-hydroxyvitamin D [25(OH)D] in blood. Accumulatingdata indicate that, e.g., in pregnant women, hemodialysis patients, chronic kidney disease, liver failure, and bladder and pancreatic cancers, the measurement of free 25(OH)D in serum provides more relevant diagnostic information than measurement of total 25(OH)D. The aim of this study was to develop and validate an ELISA for direct measurement of free 25(OH)D in serum. A simple and direct ELISA was developed, based on a two-step immunoassay procedure performed ina microtiter plate. The assay has been characterizedin terms of precision (4–10% CV, according toconcentration), sensitivity (limits of blank = 0.5–1.0 pg/mL and LODs = 1.3–1.8 pg/mL), accuracy (correlation to dialysis, ELISA = 0.99xdialysis-0.5 pg/mL, r2 = 0.74), cross-reactivity of the antibody for the D2 form (77%),and addition of both VDBP and albumin (35–38%recovery upon addition of VDBP, 53–58% upon addition of albumin). The assay has already been usedin multiple studies, including its comparison with calculation methods and in studies of patients with liver failure, different ethnic groups, supplemented mice, respiratory diseases, and obesity. The free 25(OH)D ELISA can be used in studies as a valuable toolto establish the clinical relevance of free 25(OH)D.
Welfare assessment in traditional mountain dairy farms: above and beyond resource-based measures
Authors: Zuliani A , Romanzin A , Corazzin M , Salvador S , Abrahantes JC , Bovolenta S 
Published: May 2017

AbstractThe Welfare Quality® project was one of the largest research undertakings into animal welfare. Despite animal-based measures (ABMs) being increasingly preferred over resource-based measures (non-ABMs), the Welfare Quality® protocol (WQ) for dairy cattle has a non-ABM, Ease of Movement that classifies housing systems using a threshold of 100 days of access to pasture or, inversely, of 265 days tethered. Since traditional transhumance to alpine pastures lasts for approximately 90 days most farms tend to be classified as having a year-round tie-stall system by the WQ. The aim of this study was two-fold: to discuss the appropriateness of using non-ABMs and related thresholds in welfare scoring and to classify mountain dairy farms using ABM records. Initially, a comparison was made with scores obtained using the WQ protocol in farms where cows were: i) tethered all year; and ii) tethered but having regular exercise or reared in loose-housing systems. No difference in terms of welfare was detected between groups of farms regarding their housing systems, thus we investigated welfare focusing on ABMs. Therefore, farms were grouped into four clusters, according to their ABMs. The results indicated that good ABM scores can be obtained in most traditional mountain farms where cows are tethered for around 275 days a year and have access to highland pasture for the remaining 90 days. In this study, ABMs were effective tools for classifying mountain farms according to their welfare status and for informing targeted action to improve dairy cow welfare.
Public attitudes toward animals and the influential factors in contemporary China
Authors: Su B , Martens P 
Published: May 2017

AbstractThe relationship between public attitudes toward animals and human demographics has been well documented during the last few decades, but the influence of human ethical ideologies on public attitudes toward animals and animal welfare has been rarely investigated, especially in developing countries, such as China. The present study introduced two scales (Animal Issue Scale [AIS] and Animal Attitude Scale [AAS]) to investigate the Chinese people's attitudes toward animals and the manner in which their outlook related to ethical ideologies (idealism and relativism), which classified people into four ethical positions: situationists, subjectivists, absolutists and exceptionists. Moreover, it also showed how ethical ideologies and their interaction with human demographics influence respondents’ attitudes toward animals. The results of an online questionnaire (n = 504) distributed throughout China suggest that compared with middle-aged and old respondents, the young demonstrated significantly more positive attitudes toward animals. Absolutists showed the most positive attitudes toward animals, while subjectivists showed the least. People's attitudes toward animals were positively affected by idealism, which confirms previous findings in developed countries. However, people's attitudes toward animals were negatively affected by relativism, which is inconsistent with findings in developed countries, showing that ethical relativism failed to influence attitudes toward animals. Our results indicate that the same mechanisms underlying the effect of ethical idealism on attitudes toward animals might work in different countries to increase awareness on animal welfare. However, the manner in which ethical relativism influences attitudes toward animals may differ between developed and developing countries.
La production poétique en milieu minoritaire sous le signe de la concomitance : le cas de J. R. Léveillé
Authors: Hains Julia 
Published: May 2017

Au tournant des années 1970, on observe chez plusieurs écrivains francophones de l’Ouest du Canada une poésie tournée vers sa propre spécificité, engagée dans des problématiques d’ordre formel et qui a tendance à se dégager des questions sociales et politiques. C’est notamment le cas de l’oeuvre poétique de J. R. Léveillé, qui demande a priori à être lue pour sa valeur intrinsèque, refusant d’emblée les lectures référentielles. Dans le présent article, nous verrons toutefois que le recours à certaines stratégies déployées dans les textes poétiques de cet auteur est symptomatique d’une tension observable dans les littératures francophones du Canada entre les prétentions universalistes de l’oeuvre et la condition de minoritaire qui lui est inféodée et qui se négocie ici par l’entremise de l’exercice que nous appelons « concomitance ».
Directly Isolated Allogeneic Virus–Specific T Cells in Progressive Multifocal Leukoencephalopathy
Authors: Möhn Nora , Grote-Levi Lea , Wattjes Mike P. , Bonifacius Agnes , Holzwart Dennis , Hopfner Franziska , Nay Sandra , Tischer-Zimmermann Sabine , Saßmann Mieke Luise , Schwenkenbecher Philipp , Sühs Kurt-Wolfram , Mahmoudi Nima , Warnke Clemens , Zimmermann Julian , Hagin David , Goudeva Lilia , Blasczyk Rainer , Koch Armin , Maecker-Kolhoff Britta , Eiz-Vesper Britta , Höglinger Günter , Skripuletz Thomas 
Published: October 2024

ImportanceProgressive multifocal leukoencephalopathy (PML) is a life-threatening viral infection with no approved antiviral treatment.ObjectiveTo determine whether restoring the compromised immune system of patients with PML with directly isolated allogeneic virus–specific (DIAVIS) T cells is a promising therapeutic strategy, especially if other curative options are absent.Design, Setting, and ParticipantsA retrospective case series of patients with PML who were treated with DIAVIS T cells was conducted between March 2020 and February 2022. T cells were isolated from healthy donors within 24 hours and targeted against the BK polyomavirus. Patients with PML were treated monocentrically. Eligibility for treatment with DIAVIS T cells was assessed for patients with confirmed PML, and exclusion criteria included stable PML disease and previous treatment with natalizumab.ExposureFresh DIAVIS T cells were administered with a maximum dose of 2 × 104 CD3+ cells/kg body weight. Remaining T cells were cryopreserved in divided doses and administered in additional treatments approximately 2 and 6 weeks later.Main Outcomes and MeasuresPrimary outcome measures were clinical response and survival of patients, compared with the outcomes of a historical reference group of PML cases receiving best supportive treatment (BST) and with recently published real-world data of patients with PML who were treated with immune checkpoint inhibition.ResultsThe study cohort consisted of 28 patients (median [IQR] age, 60 [51-72] years; 20 male [71.4%]). Twenty-two patients (79%) treated with DIAVIS T cells showed response, resulting in significant clinical stabilization or improvement and a reduction in viral load. Six individuals (21%) were classified as nonresponders, deteriorated rapidly, and died, as did 2 other patients during a 12-month follow-up. Older age was the only predictor of a poor treatment response. Survival analysis revealed better 12-month survival rates (hazard ratio, 0.42; 95% CI, 0.24-0.73; P =.02) from diagnosis for patients treated with DIAVIS T cells (18 of 26 [69%]; 12-mo survival rate, 69%) compared with historical controls with BST (57 of 113 [50%]; 12-mo survival rate, including censored data, 45%).Conclusion and RelevanceThis case series of DIAVIS T-cell therapy in PML provides first class IV evidence suggesting efficacy to reduce mortality and improve functional outcome. Further prospective studies are required to confirm these results.
Cannabis Use During Adolescence and Young Adulthood and Academic Achievement
Authors: Chan Olsen , Daudi Ahad , Ji David , Wang Mathias , Steen Jeremy P. , Parnian Parsia , Li Crystal , Xiong Annie , Zhang Wei , Lopes Luciane C. , MacKillop James , Busse Jason W. , Wang Li 
Published: October 2024

ImportanceCannabis use during adolescence and young adulthood may affect academic achievement; however, the magnitude of association remains unclear.ObjectiveTo conduct a systematic review evaluating the association between cannabis use and academic performance.Data SourcesCINAHL, EMBASE, MEDLINE, PsycInfo, PubMed, Scopus, and Web of Science from inception to November 10, 2023.Study SelectionObservational studies examining the association of cannabis use with academic outcomes were selected. The literature search identified 17 622 unique citations.Data Extraction and SynthesisPairs of reviewers independently assessed risk of bias and extracted data. Both random-effects models and fixed-effects models were used for meta-analyses, and the Grading of Recommendations Assessment, Development, and Evaluation approach was applied to evaluate the certainty of evidence for each outcome. Data were analyzed from April 6 to May 25, 2024.Main Outcomes and MeasuresSchool grades, school dropout, school absenteeism, grade retention, high school completion, university enrollment, postsecondary degree attainment, and unemployment.ResultsSixty-three studies including 438 329 individuals proved eligible for analysis. Moderate-certainty evidence showed cannabis use during adolescence and young adulthood was probably associated with lower school grades (odds ratio [OR], 0.61 [95% CI, 0.52-0.71] for grade B and above); less likelihood of high school completion (OR, 0.50 [95% CI, 0.33-0.76]), university enrollment (OR, 0.72 [95% CI, 0.60-0.87]), and postsecondary degree attainment (OR, 0.69 [95% CI, 0.62-0.77]); and increased school dropout rate (OR, 2.19 [95% CI, 1.73-2.78]) and school absenteeism (OR, 2.31 [95% CI, 1.76-3.03]). Absolute risk effects ranged from 7% to 14%. Low-certainty evidence suggested that cannabis use may be associated with increased unemployment (OR, 1.50 [95% CI, 1.15-1.96]), with an absolute risk increase of 9%. Subgroup analyses with moderate credibility showed worse academic outcomes for frequent cannabis users and for students who began cannabis use earlier.Conclusions and RelevanceCannabis use during adolescence and young adulthood was probably associated with increases in school absenteeism and dropout; reduced likelihood of obtaining high academic grades, graduating high school, enrolling in university, and postsecondary degree attainment; and perhaps increased unemployment. Further research is needed to identify interventions and policies that mitigate upstream and downstream factors associated with early cannabis exposure.
AAPM BTSC Report 377.B: Physicist brachytherapy training in 2022 – A survey of therapeutic medical physics residents
Authors: Simiele Samantha J. , Aima Manik , Melhus Christopher S. , Richardson Susan L. 
Published: October 2024

AbstractBackgroundA survey of medical physics residency program directors was conducted in Spring 2021 to examine the current state of brachytherapy (BT) training during residency. In this related work, a subsequent survey of therapeutic medical physics residents in 2022 was conducted to assess the confidence and experience of the trainees. Concerns for access to high‐quality and diverse training in BT have escalated in importance due to recent declines in BT utilization.MethodsA survey consisting of 26 questions was designed by a working unit of the Brachytherapy Subcommittee of the American Association of Physicists in Medicine (AAPM) and approved for distribution by the Executive Committee of the AAPM. The survey was distributed to current trainees and recent graduates of the Commission on Accreditation of Medical Physics Education Programs accredited therapeutic medical physics residency programs by the AAPM. The participant response was anonymously recorded in an online platform and subsequently analyzed using spreadsheet software.ResultsThe survey was distributed to 796 current medical physics residents or recent graduates over the course of 6 weeks in February and March of 2022. The survey received 736 views and a total of 182 responses were collected, with 165 respondents completing the survey in full. Among those responses, 110 had completed their residency training, with program start dates ranging from calendar years 2015 to 2021. Individual responses from the survey takers (including partial survey submissions) were evaluated and analyzed to compile results.ConclusionsMedical physics residents reported the highest levels of confidence and caseload for gynecological BT procedures when compared with other surveyed treatment techniques. This indicates opportunities to improve training and increase access to clinical caseload are needed in order to improve competency and confidence. Time constraints (clinical and rotation‐based) were indicated as impediments to BT proficiency. Medical physics residents reported enthusiasm for additional training opportunities in BT, and it is evident that additional structure and programs are required to ensure adequate access to BT training during residency.