bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Crowd logistics”: the contribution of social crowds in logistics activities
Authors: Mladenow Andreas , Bauer Christine , Strauss Christine 
Published: August 2016

Purpose
The paper aims to provide the necessary basis for a novel interdisciplinary research field. Various types and implementations of crowdsourcing have emerged in the market; many of them are related to logistics. While we can identify plenty of crowd logistics applications using information technology capabilities and information sharing in practice, theories behind this phenomenon have received only limited attention. This paper accounts for filling this research gap by analyzing the crowd’s contributions in logistics of goods and information.

Design/methodology/approach
This paper is part of an ongoing research endeavor in the field of location-based crowdsourcing. It represents conceptual work that builds on a literature review enriched with an in-depth analysis of real-world examples in the field of crowd logistics. Using a scoring method, we provide an example how a company may evaluate the alternatives of crowd logistics. The main approach is an analysis of variants of how the social crowd may be integrated in logistics processes. The work is conceptual in its core. Thereby, we use real-world examples of crowdsourcing applications to underpin the evaluated variants of crowd logistics.

Findings
The paper presents relevant theoretical background on crowd logistics. The authors differentiate between variants of crowd logistics with their flow of materials, goods and information. Thereby they zoom in the type, significance and process flow of the crowd’s contributions. They discuss potential advantages and challenges of logistics with the performing crowd and deeply discuss opportunities and challenges from a business and from an individual’s perspective. Finally, they highlight a route map for future research directions in this novel interdisciplinary research field.

Research limitations/implications
As this work is conceptual in its core, generalizations may be drawn only with great care. Still, we are in a position to propose a route map for further research in this area in this paper. Also the integration of an analysis of a scale of real-world applications allows us to highlight our research’s practical relevance and implications.

Originality/value
The main contribution of this paper is an in-depth analysis and consolidation of innovative crowd logistics applications to provide an overview on recent implementations. The authors propose a categorization scheme and contribute with a route map for further research in the field of crowd logistics.
Application of ICD‐PM to preterm‐related neonatal deaths in South Africa and United Kingdom
Authors: Allanson ER , Vogel JP , Tunçalp Ӧ , Gardosi J , Pattinson RC , Francis A , Erwich JJHM , Flenady VJ , Frøen JF , Neilson J , Quach A , Chou D , Mathai M , Say L , Gülmezoglu AM 
Published: August 2016

ObjectiveWe explore preterm‐related neonatal deaths using the WHO application of the International Classification of Disease (ICD‐10) to deaths during the perinatal period: ICD‐PM as an informative case study, where ICD‐PM can improve data use to guide clinical practice and programmatic decision‐making.DesignRetrospective application of ICD‐PM.SettingSouth Africa, and the UK.PopulationPerinatal death databases.MethodsDescriptive analysis of neonatal deaths and maternal conditions present.Main outcome measuresCauses of preterm neonatal mortality and associated maternal conditions.ResultsWe included 98 term and 173 preterm early neonatal deaths from South Africa, and 956 term and 3248 preterm neonatal deaths from the UK. In the South African data set, the main causes of death were respiratory/cardiovascular disorders (34.7%), low birthweight/prematurity (29.2%), and disorders of cerebral status (25.5%). Amongst preterm deaths, low birthweight/prematurity (43.9%) and respiratory/cardiovascular disorders (32.4%) were the leading causes. In the data set from the UK, the leading causes of death were low birthweight/prematurity (31.6%), congenital abnormalities (27.4%), and deaths of unspecified cause (26.1%). In the preterm deaths, the leading causes were low birthweight/prematurity (40.9%) and deaths of unspecified cause (29.6%). In South Africa, 61% of preterm deaths resulted from the maternal condition of preterm spontaneous labour. Among the preterm deaths in the data set from the UK, no maternal condition was present in 36%, followed by complications of placenta, cord, and membranes (23%), and other complications of labour and delivery (22%).ConclusionsICD‐PM can be used to appraise the maternal and newborn conditions contributing to preterm deaths, and can inform practice.Tweetable abstractICD‐PM can be used to appraise maternal and newborn contributors to preterm deaths to improve quality of care.
Effects of Freeze‐Dried Vegetable Products on the Technological Process and the Quality of Dry Fermented Sausages
Authors: Eisinaite Viktorija , Vinauskiene Rimante , Viskelis Pranas , Leskauskaite Daiva 
Published: August 2016

AbstractThe aim of this study was to compare the chemical composition of freeze‐dried vegetable powders: celery, celery juice, parsnip and leek. The effect of different freeze‐dried vegetables onto the ripening process and the properties of dry fermented sausages was also evaluated. Vegetable products significantly (p < 0.05) differed in their chemical composition: celery products contained higher amounts of nitrates, total phenolic compounds and lower amounts of sucrose, parsnip had higher concentration of proteins, leek was rich in fat. The analysis of pH, water activity, lactic acid bacteria, coagulase‐positive staphylococci and coliforms content showed that the incorporation of freeze‐dried vegetables had no negative effect on the fermentation and ripening process of dry fermented sausages. In addition, the color parameters for sausages with the added lyophilised celery products were considerable (p < 0.05) more stable during these processes. At the end of the ripening process the sausages made with lyophilised celery juice were characterised by higher lightness and lower hardness than those made with the addition of other vegetable products and control. Freeze‐dried celery, celery juice, parsnip and leek have some potential for the usage as a functional ingredient or as a source for indirect addition of nitrate in the production of fermented sausages.
Drinking Motives Predict Subjective Effects of Alcohol and Alcohol Wanting and Liking During Laboratory Alcohol Administration: A Mediated Pathway Analysis
Authors: Wardell Jeffrey D. , Ramchandani Vijay A. , Hendershot Christian S. 
Published: August 2016

BackgroundMotivational models of alcohol use suggest that individual differences in sensitivity to the acute subjective effects of alcohol play an important role in motivational pathways to alcohol use. However, few studies have examined the link between drinking motives and subjective responses to alcohol. This study investigated the associations of coping and enhancement drinking motives with subjective stimulant and sedative effects during a laboratory alcohol administration session. We also examined whether stimulation and sedation following alcohol administration mediated the relationships between drinking motives and postalcohol ratings of alcohol wanting and liking.MethodsHeavy episodic drinkers (n = 147, ages 19 to 25) at 2 sites participated in an intravenous alcohol administration session in which blood alcohol concentration was raised to a target of 80 mg% over 20 minutes. Participants completed measures of stimulation and sedation at baseline and 20 minutes and also rated alcohol liking and wanting at 20 minutes. Drinking motives and alcohol use were assessed during a previous laboratory visit.ResultsA path analysis controlling for baseline stimulation and sedation showed that enhancement motives were positively associated with postalcohol stimulation and negatively associated with postalcohol sedation. In contrast, coping motives were positively associated with postalcohol sedation. In turn, postalcohol stimulation, but not sedation, was associated with alcohol wanting and liking. Further, indirect pathways from enhancement motives to postalcohol wanting and liking mediated through postalcohol stimulation were statistically significant. Coping motives, on the other hand, were directly associated with increased postalcohol wanting and liking.ConclusionsThe results demonstrate that drinking motives are linked with individual differences in sensitivity to the effects of alcohol, which may serve as a mechanism underlying alcohol reinforcement and the motivation to consume more alcohol during a drinking episode.
Effects of long‐term fire exclusion and frequent fire on plant community composition: A case study from semi‐arid shrublands
Authors: Knuckey Chris G. , Van Etten Eddie J.B. , Doherty Tim S. 
Published: August 2016

AbstractTime since last fire and fire frequency are strong determinants of plant community composition in fire‐prone landscapes. Our study aimed to establish the influence of time since last fire and fire frequency on plant community composition and diversity of a south‐west Australian semi‐arid shrubland. We employed a space‐for‐time approach using four fire age classes: ‘young’, 8–15 years since last fire; ‘medium’, 16–34; ‘old’, 35–50; and ‘very old’, 51–100; and three fire frequency classes: burnt once, twice and three times within the last 50 years. Species diversity was compared using one‐way ANOVA and species composition using PERMANOVA. Soil and climatic variables were included as covariables to partition underlying environmental drivers. We found that time since last fire influenced species richness, diversity and composition. Specifically, we recorded a late successional transition from woody seeders to long‐lived, arid‐zone, resprouting shrub species. Fire frequency did not influence species richness and diversity but did influence species composition via a reduction in cover of longer‐lived resprouter species – presumably because of a reduced ability to replenish epicormic buds and/or sufficient starch stores. The distinct floristic composition of old and very old habitat, and the vulnerability of these areas to wildfires, indicate that these areas are ecologically important and management should seek to preserve them.
The remarkable Australian rove beetle genus Myotyphlus: its cryptic diversity and significance for exploring mutualism among insects and mammals (Coleoptera: Staphylinidae)
Authors: Solodovnikov Alexey , Jenkins Shaw Josh 
Published: August 2016

AbstractMyotyphlus jansoni (Matthews ) a rare and the only rove beetle species from the subtribe Amblyopinina (Staphylininae) in Australia that occurs in the fur of small mammals, is revised. Examination of the male genitalia of this species leads to identification of three distinct species: M. jansoni from Tasmania, Myotyphlus newtoni sp. nov. and Myotyphlus wurra sp. nov. described as new from mainland south‐eastern Australia. Distribution, bionomics and host associations are summarised for all three species with the conclusion that at least M. newtoni also occurs in bat guano in caves, or on the ground. Probably, none of the Myotyphlus species is specific to a particular mammal species although M. wurra is only known from one species of Rattus, while the genus as a whole occurs on several species of Rattus, on Pseudomys higginsi and on Antechinus swainsonii. Myotyphlus seems not as strongly associated with its host mammals as the more diverse Neotropical mammal‐associated genera of Amblyopinina, which is consistent with the shorter time period of those respective mammals' presence in Australia. Reviewed in the broad context of insect–mammal mutualisms, the ecology and putative sister‐group relationships of Myotyphlus suggest an independent origin for the mammal‐associated lifestyle in Myotyphlus and Neotropical Amblyopinina, respectively.
FTDP‐17 with Pick body‐like inclusions associated with a novel tau mutation, p.E372G
Authors: Tacik Pawel , DeTure Michael A. , Carlomagno Yari , Lin Wen‐Lang , Murray Melissa E. , Baker Matthew C. , Josephs Keith A. , Boeve Bradley F. , Wszolek Zbigniew K. , Graff‐Radford Neill R. , Parisi Joseph E. , Petrucelli Leonard , Rademakers Rosa , Isaacson Richard S. , Heilman Kenneth M. , Petersen Ronald C. , Dickson Dennis W. , Kouri Naomi 
Published: August 2016

AbstractMutations in microtubule‐associated protein tau gene (MAPT) cause frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP‐17). Here, we describe a patient with FTDP‐17 and a novel missense mutation in exon 13 of MAPT, p.E372G. We compare clinicopathologic features of this patient to two previously unreported patients with another exon 13 mutation, p.G389R. The patient with the p.E372G mutation was a 40‐year‐old man with behavioral variant frontotemporal dementia (bvFTD), who subsequently developed agrammatic speech and parkinsonism. One of the FTDP‐17 patients with p.G389R mutation presented at age 24 with agrammatic variant of primary progressive aphasia, and subsequently behavioral dysfunction. The other presented at age 53 with bvFTD, followed by agrammatic speech and corticobasal syndrome. Neuropathologic features of FTDP‐17 due to p.E372G were similar to those of p.G389R, including tau‐immunoreactive Pick body‐like neuronal inclusions and swollen, tapering thread‐like processes in white matter immunoreactive for 3‐repeat and 4‐repeat tau. Biochemical analysis of insoluble tau showed similar isoform compositions in p.E372G and p.G389R. Functional studies of the p.E372G mutation showed marked increase in tau filament formation and its reduced ability to promote microtubule assembly. Together these findings indicate that p.E372G is a pathogenic MAPT mutation that causes FTDP‐17 similar to p.G389R.
Faulty splicing and cytoskeleton abnormalities in Huntington's disease
Authors: Fernández‐Nogales Marta , Santos‐Galindo María , Hernández Ivó H. , Cabrera Jorge R. , Lucas José J. 
Published: August 2016

AbstractHuntington's disease (HD) is caused by a CAG‐repeat encoding a polyglutamine (polyQ) tract in the huntingtin protein. There is plenty of evidence of polyQ‐driven toxicity. However, CAG repeat RNA‐driven alteration of splicing has recently been proposed in analogy to CUG‐repeat diseases. Here we review the reported alteration of the CAG‐repeat associated splicing factor SRSF6 in brains of HD patients and mouse models and how this correlates with altered splicing of, at least, two microtubule‐associated proteins in HD, namely MAPT (tau) and MAP2. Regarding tau, altered splicing of exon 10 has been reported, along with increased levels and 4R/3R‐tau ratio and detection of tau in a new nuclear rod‐shaped histopathological hallmark termed tau nuclear rod (TNR) or tau nuclear indentation (TNI). These findings, together with an attenuation of HD phenotype in R6/1 mice with tau deficiency and subsequent studies showing increased phosphorylation in mouse models and increased levels in CSF of patients, has led to proposing HD as a tauopathy. Regarding MAP2, an increase in its juvenile form and a decrease in total MAP2 together with redistribution from dendrites to soma is observed in HD patients, which may contribute to the dendritic atrophy in HD. Furthermore, MAP2 positive structures filling nuclear indentations have occasionally been found and co‐localized with tau. Therefore, altered MAP function with imbalance in tau/MAP2 content could contribute to HD striatal atrophy and dysfunction. Besides, TNIs might be indicative of such MAP abnormalities. TNIs are also found in early pathology Alzheimer's disease and in tauopathy mice over‐expressing mutant 4R‐tau. This indicates that tau alteration is sufficient for TNI detection, which becomes a marker of increased total tau and/or altered 4R/3R‐tau ratio and reporter of pathology‐associated nuclear indentations. Altogether, these recent studies suggest that correcting the SRSF6‐driven missplicing and/or microtubule‐associated imbalance might be of therapeutic value in HD.
Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF
Authors: Puigdellívol Mar , Saavedra Ana , Pérez‐Navarro Esther 
Published: August 2016

AbstractOne of the main focuses in Huntington's disease (HD) research, as well as in most neurodegenerative diseases, is the development of new therapeutic strategies, as currently there is no treatment to delay or prevent the progression of the disease. Neuronal dysfunction and neuronal death in HD are caused by a combination of interrelated pathogenic processes that lead to motor, cognitive and psychiatric symptoms. Understanding how mutant huntingtin impacts on a plethora of cellular functions could help to identify new molecular targets. Although HD has been classically classified as a neurodegenerative disease affecting voluntary movement, lately cognitive dysfunction is receiving increased attention as it is very invalidating for patients. Thus, an ambitious goal in HD research is to find altered molecular mechanisms that contribute to cognitive decline. In this review, we have focused on those findings related to corticostriatal and hippocampal cognitive dysfunction in HD, as well as on the underlying molecular mechanisms, which constitute potential therapeutic targets. These include alterations in synaptic plasticity, transcriptional machinery and neurotrophic and neurotransmitter signaling.
The Endangered Arctic, the Arctic as Resource Frontier: Canadian News Media Narratives of Climate Change and the North
Authors: Stoddart Mark C.J. , Smith Jillian 
Published: August 2016

The Arctic is one of the most radically altered parts of the world due to climate change, with significant social and cultural impacts as a result. Using discourse network analysis and qualitative textual analysis of articles published in the Globe and Mail and National Post during the period 2006 to 2010, we identify and analyze key frames that interpret the implications of climate change on the Arctic. We examine Canadian national news media coverage to ask: How does the Arctic enter media coverage of climate change? Is there evidence of a climate justice discourse in relation to regional disparities in the risks and harms of climate change between northern and southern Canada? Climate change in the Arctic is often framed through the lens of Canadian national interests, which downplays climate‐related social impacts that are already occurring at subnational political and geographical scales.L'Arctique est une des régions du monde la plus radicalement altérée par le changement climatique, menant comme résultat des importants changements sociaux et culturels. En utilisant l'analyse des réseaux de discours ainsi que l'analyse textuelle qualitative des articles publiés dans le Globe and Mail et le National Post de 2006 à 2010, nous identifions and analysons des cadres clés qui servent à interpréter les conséquences du changement climatique dans l'Arctique. Nous examinons la couverture des médias nationaux canadiens pour pouvoir demander : comment est‐ce que l'Arctique s'insère dans la couverture médiatique du changement climatique? Est‐ce qu'il y a de la preuve d'un discours de la justice climatique en relation des disparités régionales des risques et méfaits du changement climatique entre le Canada du nord et du sud? Le changement climatique dans l'Arctique est souvent encadré à travers le prisme des intérêts nationaux canadiens, ce qui minimise les impacts sociaux reliés au climat qui se produisent actuellement aux échelons sous‐nationaux politiques et géographiques.
New pyrazole derivative 5‐[1‐(4‐fluorophenyl)‐1H‐pyrazol‐4‐yl]‐2H‐tetrazole: synthesis and assessment of some biological activities
Authors: de Oliveira Lanussy Porfiro , da Silva Daiany Priscilla Bueno , Florentino Iziara Ferreira , Fajemiroye James Oluwagbamigbe , de Oliveira Thiago Sardinha , Marcelino Renato Ivan de Ávila , Pazini Francine , Lião Luciano Morais , Ghedini Paulo César , de Moura Soraia Santana , Valadares Marize Campos , de Carvalho Verônica Vale , Vaz Boniek Gontijo , Menegatti Ricardo , Costa Elson Alves 
Published: August 2016

The molecular modification and synthesis of compounds is vital to discovering drugs with desirable pharmacological and toxicity profiles. In response to pyrazole compounds' antipyretic, analgesic, and anti‐inflammatory effects, this study sought to evaluate the analgesic, anti‐inflammatory, and vasorelaxant effects, as well as the mechanisms of action, of a new pyrazole derivative, 5‐[1‐(4‐fluorophenyl)‐1H‐pyrazol‐4‐yl]‐2H‐tetrazole. During the acetic acid‐induced abdominal writhing test, treatments with 5‐[1‐(4‐fluorophenyl)‐1H‐pyrazol‐4‐yl]‐2H‐tetrazole reduced abdominal writhing, while during the formalin test, 5‐[1‐(4‐fluorophenyl)‐1H‐pyrazol‐4‐yl]‐2H‐tetrazole reduced licking times in response to both neurogenic pain and inflammatory pain, all without demonstrating any antinociceptive effects, as revealed during the tail flick test. 5‐[1‐(4‐fluorophenyl)‐1H‐pyrazol‐4‐yl]‐2H‐tetrazole also reduced carrageenan‐induced paw edema and cell migration during the carrageenan‐induced pleurisy test. As demonstrated by the model of the isolated organ, 5‐[1‐(4‐fluorophenyl)‐1H‐pyrazol‐4‐yl]‐2H‐tetrazole exhibits a vasorelaxant effect attenuated by Nω‐nitro‐l‐arginine methyl ester, 1H‐[1,2,4]oxadiazolo[4,3‐alpha]quinoxalin‐1‐one, tetraethylammonium or glibenclamide. 5‐[1‐(4‐fluorophenyl)‐1H‐pyrazol‐4‐yl]‐2H‐tetrazole also blocked CaCl2‐induced contraction in a dose‐dependent manner. Suggesting a safe toxicity profile, 5‐[1‐(4‐fluorophenyl)‐1H‐pyrazol‐4‐yl]‐2H‐tetrazole reduced the viability of 3T3 cells at higher concentrations and was orally tolerated, despite signs of toxicity in doses of 2000 mg/kg. Lastly, the compounds' analgesic activity might be attributed to the involvement of the NO/cGMP pathway and K+ channels observed in the vasorelaxant effect.
The impact of parental incarceration on children's care: identifying good practice principles from the perspective of imprisoned primary carer parents
Authors: Trotter Chris , Flynn Catherine , Baidawi Susan 
Published: August 2016

AbstractParental incarceration has wide‐ranging impacts on families. One key effect may be disruption to the care and legal custody of children, yet few studies have examined processes and outcomes relating to care planning for children of prisoners. This paper presents findings of interviews with 151 primary carer prisoners in two Australian states which aimed to address this research gap. The study examined care planning for children upon parental arrest, sentencing and imprisonment, stability of care arrangements and primary carer prisoners' involvement and satisfaction with care planning. Around one third of prisoners had discussions regarding children's care arrangements at arrest and imprisonment, although the issue was more commonly raised at sentencing. While there was much variation in the stability of care arrangements, children placed in out‐of‐home care experienced the most instability. A minority of prisoners reported being involved in care planning and decision‐making for children upon imprisonment, and around one third rated care planning process poorly. Prisoners were more satisfied with care planning when there were fewer movements of children, where prisoners felt involved with decision‐making, and when police officers, lawyers and corrections staff inquired about the welfare of their children. Implications for policy and future research are discussed.