bluuebunny/crossref_metadata_2025_split huggingface dataset:
Migraine and frequent tension-type headache are not associated with multiple sclerosis in a Norwegian case-control study
Authors: Gustavsen MW , Celius EG , Winsvold BS , Moen SM , Nygaard GO , Berg-Hansen P , Lie BA , Zwart J-A , Harbo HF 
Published: December 2016

Background Inconsistent results have been obtained with regard to headache comorbidity in multiple sclerosis (MS). Objective Investigate the one-year prevalence of migraine and tension-type headache (TTH) in Norwegian MS patients and relate this to clinical parameters. Methods A questionnaire concerning headache was administered to 756 MS patients and 1090 controls and used to determine the one-year prevalence of migraine and frequent TTH. Results No significant differences were seen between patients and controls or between patients with different disease course. Less migraine was observed in patients with Expanded Disability Status Scale score (EDSS) ≥4.0. Conclusions This case-control study does not support an association between migraine or TTH and MS.
Evaluating surveillance imaging for diffuse large B-cell lymphoma and Hodgkin lymphoma
Authors: Cohen Jonathon B. , Behera Madhusmita , Thompson Carrie A. , Flowers Christopher R. 
Published: December 2016

Abstract
Up to 50% of patients with Hodgkin lymphoma and diffuse large B-cell lymphoma will relapse, requiring additional therapy. Although surveillance imaging is commonly performed in clinical practice, its ability to identify asymptomatic relapses and improve survival for patients is not well defined. We evaluated the surveillance imaging role in relapse detection and reviewed its impact on survival for relapsed patients, and found that current imaging approaches do not detect most relapses prior to clinical signs and symptoms or improve survival.
Sleep disordered breathing and autonomic function in overweight and obese children and adolescents
Authors: Van Eyck Annelies , Van Hoorenbeeck Kim , De Winter Benedicte Y. , Van Gaal Luc , De Backer Wilfried , Verhulst Stijn L. 
Published: December 2016

Obstructive sleep apnoea (OSA), common in children with obesity, is associated with cardiovascular morbidity. Autonomic dysfunction has been suggested to be a key player in the development of these complications. We investigated the relationship between obesity, OSA and sympathetic activity in children.191 children with obesity were included and distributed into two groups: 131 controls and 60 with OSA. Beat-to-beat RR interval data were extracted from polysomnography for heart rate variability analysis. Urinary free cortisol levels were determined.Urinary free cortisol did not differ between groups and was not associated with OSA, independent of the level of obesity. Differences in heart rate variability measures were found: mean RR interval decreased with OSA, while low/high-frequency band ratio and mean heart rate increased with OSA. Heart rate variability measures correlated with OSA, independent of obesity parameters and age: oxygen desaturation index correlated with mean heart rate (r=0.19, p=0.009) and mean RR interval (r= −0.18, p=0.02), while high-frequency bands and low/high-frequency band ratio correlated with arterial oxygen saturation measured by pulse oximetry (SpO2) (r= −0.20, p=0.008 and r= −0.16, p=0.04) andSpO2nadir (r=0.23, p=0.003 and r= −0.19, p=0.02).These results suggest that sympathetic heart activity is increased in children with obesity and OSA. Measures of hypoxia were related to increased sympathetic tone, suggesting that intermittent hypoxia is involved in autonomic dysfunction.
Pathway collages: personalized multi-pathway diagrams
Authors: Paley Suzanne , O’Maille Paul E. , Weaver Daniel , Karp Peter D. 
Published: December 2016

Abstract
Background
Metabolic pathway diagrams are a classical way of visualizing a linked cascade of biochemical reactions. However, to understand some biochemical situations, viewing a single pathway is insufficient, whereas viewing the entire metabolic network results in information overload. How do we enable scientists to rapidly construct personalized multi-pathway diagrams that depict a desired collection of interacting pathways that emphasize particular pathway interactions?

Results
We define software for constructing personalized multi-pathway diagrams called pathway-collages using a combination of manual and automatic layouts. The user specifies a set of pathways of interest for the collage from a Pathway/Genome Database. Layouts for the individual pathways are generated by the Pathway Tools software, and are sent to a Javascript Pathway Collage application implemented using Cytoscape.js. That application allows the user to re-position pathways; define connections between pathways; change visual style parameters; and paint metabolomics, gene expression, and reaction flux data onto the collage to obtain a desired multi-pathway diagram. We demonstrate the use of pathway collages in two application areas: a metabolomics study of pathogen drug response, and an Escherichia coli metabolic model.

Conclusions
Pathway collages enable facile construction of personalized multi-pathway diagrams.
New tools to analyze overlapping coding regions
Authors: Bayegan Amir H. , Garcia-Martin Juan Antonio , Clote Peter 
Published: December 2016

Abstract
Background
Retroviruses transcribe messenger RNA for the overlapping Gag and Gag-Pol polyproteins, by using a programmed -1 ribosomal frameshift which requires a slippery sequence and an immediate downstream stem-loop secondary structure, together called frameshift stimulating signal (FSS). It follows that the molecular evolution of this genomic region of HIV-1 is highly constrained, since the retroviral genome must contain a slippery sequence (sequence constraint), code appropriate peptides in reading frames 0 and 1 (coding requirements), and form a thermodynamically stable stem-loop secondary structure (structure requirement).

Results
We describe a unique computational tool, RNAsampleCDS, designed to compute the number of RNA sequences that code two (or more) peptides p,q in overlapping reading frames, that are identical (or have BLOSUM/PAM similarity that exceeds a user-specified value) to the input peptides p,q. RNAsampleCDS then samples a user-specified number of messenger RNAs that code such peptides; alternatively, RNAsampleCDS can exactly compute the position-specific scoring matrix and codon usage bias for all such RNA sequences. Our software allows the user to stipulate overlapping coding requirements for all 6 possible reading frames simultaneously, even allowing IUPAC constraints on RNA sequences and fixing GC-content.
We generalize the notion of codon preference index (CPI) to overlapping reading frames, and use RNAsampleCDS to generate control sequences required in the computation of CPI. Moreover, by applying RNAsampleCDS, we are able to quantify the extent to which the overlapping coding requirement in HIV-1 [resp. HCV] contribute to the formation of the stem-loop [resp. double stem-loop] secondary structure known as the frameshift stimulating signal. Using our software, we confirm that certain experimentally determined deleterious HCV mutations occur in positions for which our software RNAsampleCDS and RNAiFold both indicate a single possible nucleotide. We generalize the notion of codon preference index (CPI) to overlapping coding regions, and use RNAsampleCDS to generate control sequences required in the computation of CPI for the Gag-Pol overlapping coding region of HIV-1. These applications show that RNAsampleCDS constitutes a unique tool in the software arsenal now available to evolutionary biologists.

Conclusion
Source code for the programs and additional data are available at http://bioinformatics.bc.edu/clotelab/RNAsampleCDS/.
Genome sequence and overview of Oligoflexus tunisiensis Shr3T in the eighth class Oligoflexia of the phylum Proteobacteria
Authors: Nakai Ryosuke , Fujisawa Takatomo , Nakamura Yasukazu , Baba Tomoya , Nishijima Miyuki , Karray Fatma , Sayadi Sami , Isoda Hiroko , Naganuma Takeshi , Niki Hironori 
Published: December 2016

AbstractOligoflexus tunisiensis Shr3T is the first strain described in the newest (eighth) class Oligoflexia of the phylum Proteobacteria. This strain was isolated from the 0.2-μm filtrate of a suspension of sand gravels collected in the Sahara Desert in the Republic of Tunisia. The genome of O. tunisiensis Shr3T is 7,569,109 bp long and consists of one scaffold with a 54.3% G + C content. A total of 6,463 genes were predicted, comprising 6,406 protein-coding and 57 RNA genes. Genome sequence analysis suggested that strain Shr3T had multiple terminal oxidases for aerobic respiration and various transporters, including the resistance-nodulation-cell division-type efflux pumps. Additionally, gene sequences related to the incomplete denitrification pathway lacking the final step to reduce nitrous oxide (N2O) to nitrogen gas (N2) were found in the O. tunisiensis Shr3T genome. The results presented herein provide insight into the metabolic versatility and N2O-producing activity of Oligoflexus species.
Joint inversion of seismic, vertical seismic profiling, and crosswell data — A case study from China
Authors: Yuan Hemin , Han De-hua , Li Hui , Cao Danping 
Published: December 2016

Three-dimensional poststack and prestack seismic inversion results such as P- and S-impedance are commonly used for reservoir characterization. However, the frequency bandwidth of surface-based reflection seismic surveys usually ranges from 10 to 70 Hz, and these surveys have limited vertical resolution. The frequency bandwidth of vertical seismic profiling (VSP) and crosswell data is much wider than that of surface reflection seismic data, and it can give a detailed illumination of the subsurface around the borehole. We test a joint inversion method that integrated surface reflection seismic, VSP, and crosswell data. To better constrain the inversion results, we further integrate a posteriori information on the reflectivity obtained from petrophysics data into the inversion procedure. The a posteriori distribution we use is a modified-Cauchy distribution obtained from the statistical analysis of petrophysics data. To demonstrate the effectiveness of our algorithm, we applied our inversion strategy to a 2D synthetic model and a real seismic data set, and an uncertainty assessment was also performed. The joint inversion method can detect the thin layers that surface seismic inversion fail to, demonstrating the higher resolution of the method.
The Emerging Opportunities for Innovation in Natural Resource-based Industries in Latin America: Only Potential or Being Realised?
Authors: Dantas Eva , Marin Anabel , Figueiredo Paulo N. , Bravo-Ortega Claudio 
Published: December 2016

Increasing innovation opportunities in natural resources industries are transforming these industries, making them more dynamic and useful platforms for development. Latin American countries show a mixed record in exploiting these new opportunities.
Μουσείο, λογοτεχνία και εκπαίδευση: ενδεικτικά παραδείγματα από Ελλάδα και Γερμανία
Authors: Mortaki Sapfo , Blioumi Aglaia 
Published: December 2016

<p class="Summary">Το μουσείο αποτελεί χώρο μη τυπικής μάθησης, όπου οι εκπαιδευτικές διαδικασίες στοχεύουν στη διασύνδεση της μάθησης με τον πολιτισμό, την ψυχαγωγία, την έμπνευση, τη δημιουργία, ενώ η τελευταία ενεργοποιείται από τα εκτιθέμενα αντικείμενα. Τα μουσειακά εκθέματα προσφέρονται για πολλαπλές ερμηνείες και είναι δυνατόν να ωθήσουν τους εκπαιδευόμενους στην αναζήτηση της ερμηνείας τους με σκοπό την ανακάλυψη της γνώσης. Ως εκ τούτου, τα μουσεία διοργανώνουν εκθέσεις με στόχο τη γνωστική και ψυχολογική εμπλοκή του κοινού/μαθητών με τα εκθέματα, ενώ ειδικότερα τα λογοτεχνικά μουσεία στοχεύουν στη λογοτεχνική μέθεξη των επισκεπτών που διδακτικά επιτυγχάνεται διά της ανακαλυπτικής μεθόδου, συχνά υπό παιγνιώδη μορφή. Κατά συνέπεια, οι επισκέπτες/μαθητές γίνονται συμμέτοχοι στην εμπειρία αυτή και όχι απλοί αποδέκτες μιας ήδη διαμορφωμένης έκθεσης. Στην παρούσα μελέτη παρουσιάζονται δύο παραδείγματα εκπαιδευτικών προγραμμάτων μουσείων, ένα από την Ελλάδα και ένα από τη Γερμανία, με στόχο τη διερεύνηση ομοιοτήτων αλλά και διαφορών στην εκπαιδευτική πράξη, καθώς η συγκριτική διερεύνηση εκπαιδευτικών προγραμμάτων σπανίζει ακόμη και στη διεθνή βιβλιογραφία.</p>
Διερεύνηση συμπληρωματικής εξ αποστάσεως εκπαίδευσης στο πλαίσιο ενισχυτικής διδασκαλίας μαθηματικών με την αξιοποίηση εκπαιδευτικού λογισμικού
Authors: Παπαφιλίππου Νικόλαος , Τσιάτσος Θρασύβουλος , Μανούσου Ευαγγελία , Λιοναράκης Αντώνης 
Published: December 2016

Σκοπός του παρόντος άρθρου είναι η διερεύνηση συμπληρωματικής εξ Αποστάσεως εκπαίδευσης στο πλαίσιο ενισχυτικής διδασκαλίας των Μαθηματικών αξιοποιώντας εκπαιδευτικό λογισμικό, μέσω της πλατφόρμας Ηλεκτρονική Σχολική Τάξη (η-τάξη) του Πανελλήνιου Σχολικού Δικτύου (ΠΣΔ) και του εκπαιδευτικού παιχνιδιού μαθηματικών Volcanic Riddles. Για την εκπλήρωση του σκοπού πραγματοποιήθηκε εξ αποστάσεως παρέμβαση σε ηλεκτρονικό περιβάλλον, συμπληρωματικά με το σχολείο, σε ένα Γυμνάσιο του νομού Χαλκιδικής. Διερευνήθηκαν παράγοντες όπως οι αντιδράσεις (στάσεις) των μαθητών απέναντι στα μαθηματικά κατά την υποστήριξη της διδασκαλίας στο εξ αποστάσεως ηλεκτρονικό περιβάλλον, η επίδραση της η-τάξης και του παιχνιδιού στη στάση αυτή, η στάση απέναντι στην η-τάξη, το παιχνίδι και την εξ αποστάσεως εκπαίδευση (εξΑΕ). Όλοι μαθητές απάντησαν σε ερωτηματολόγια στάσεων πριν και μετά την παρέμβαση. Επιπλέον, οι μαθητές που μετείχαν στην η-τάξη και στο παιχνίδι απάντησαν μετά την παρέμβαση σε ερωτηματολόγιο που αφορούσε την παρουσίαση μαθηματικών εννοιών και την εξΑΕ. Ακόμη, οι μαθητές που δεν συμμετείχαν σε κάποια επιπλέον μαθησιακή δραστηριότητα πέραν της παραδοσιακής διδασκαλίας στην τάξη συμπλήρωσαν ερωτηματολόγιο σε σχέση με την εξΑΕ και τους παράγοντες που εμποδίζουν την υλοποίησή της. Σύμφωνα με τα κύρια αποτελέσματα της εργασίας οι στάσεις των μαθητών διαφοροποιήθηκαν μετά την παρέμβαση. Οι εξΑ δραστηριότητες βοήθησανστην κατανόηση των εννοιών, ενώ αύξησαν την επιθυμία τους να παρακολουθήσουν εξΑ μαθήματα.
Social Media in Greek K-12 education: A research model that explores teachers’ behavioral intention
Authors: Georgakainas Babis , Zaharias Panagiotis 
Published: December 2016

During the last decade we have witnessed a rapid growth of Web 2.0 technologies and especially the so-called online social media. Many people, from every age group but especially teenagers, participate in online communities, making new friends and exhibiting themselves and their interests in a huge international audience. It is extremely important for educational practitioners and researchers to successfully incorporate the dynamics of web 2.0 and social media in their practices. This is especially true for the teachers of K-12 education. The main aim of this study is to examine the factors that may affect teachers’ behavioral intention to use social media in their classes. Very little is known from teachers’ perspective and empirical work isvery limited, especially from Southern European countries. This research was setup inorder to develop and test a seven-factor model to explain the Greek teachers’behavioral intention to use social media in their classes. Findings reveal thatExperience, Perceived Usefulness and Trialability have a significant impact whileSubjective Norms and Perceived Ease of Use have a more weak impact on teacher’s behavioral intention.
Παραγωγή και αξιολόγηση εκπαιδευτικού υλικού με χρήση Επαυξημένης Πραγματικότητας για τη διδασκαλία της ενότητας «Αναπαράσταση της πληροφορίας στον υπολογιστή» στο Γυμνάσιο
Authors: Γιασιράνης Στέφανος , Σοφός Αλιβίζος 
Published: December 2016

Σκοπός της παρούσας εργασίας ήταν η διερεύνηση της προστιθέμενης αξίας της τεχνολογίας της Επαυξημένης Πραγματικότητας στην εκπαίδευση και συγκεκριμένα, κατά πόσο αυτή συμβάλει τόσο στη βελτίωση της επίδοσης των μαθητών, όσο και στην εμφάνιση της ψυχολογικής κατάστασης Ροής, που σύμφωνα με έρευνες έχει θετικήεπίδραση στην επίδοση τους, όταν τη βιώνουν κατά τη διάρκεια της μαθησιακής διαδικασίας. Στην έρευνα συμμετείχαν συνολικά 42 μαθητές της Β’ Γυμνασίου οι οποίοι διδάχθηκαν την «Αναπαράσταση της πληροφορίας στον υπολογιστή» χρησιμοποιώντας δύο διαφορετικές τεχνολογίες, αυτές της Επαυξημένης Πραγματικότητας και του Web. Τα ερευνητικά δεδομένα έδειξαν ότι και οι δύο τεχνολογίες συνέβαλλαν στην βελτίωση της επίδοσης των μαθητών και στην εμφάνιση Ροής στους μαθητές, με καλύτερους όμως μέσους όρους και ποσοστά για την ομάδα που αξιοποίησε την τεχνολογία της Επαυξημένης Πραγματικότητας.
Actual Directions of Researches of the Regions of Old Industrial Type in the Russian Federation
Authors: Сорокина  , Sorokina Natalia 
Published: December 2016

With use of Internet data basis of scientific electronic library eLIBRARY.RU the
most actual areas of scientific and practical researches of old-industrial regions
in the Russian Federation are defined: studying of foreign experience of state
regulation of development of territories of old-industrial type; research
of environmental problems of regions; research of problems of the cities located
in old- industrial regions; research of specific problems of development
of concrete old-industrial territories. It is proved that problems of social and
economic development of territories are most actively investigated; the special
attention is paid to justification of adequate approaches to their decision
in modern conditions. The common and specific problems interfering sustainable
social and economic development of old-industrial regions are revealed. It is
shown that the main directions of the solution of the revealed problems are:
realization of policy of reindustrialization, cluster policy, diversification of structure
of economy, improvement of strategic planning. In the conclusion the perspective
directions of scientific researches of old-industrial regions in the Russian
Federation are defined.
Bone grafts, bone graft extenders, substitutes and enhancers for acetabular reconstruction in revision total hip arthroplasty
Authors: Pierannunzii Luca , Zagra Luigi 
Published: December 2016

Acetabular bone loss is a relevant concern for surgeons dealing with a failed total hip arthroplasty. Since the femoral head is no longer available, allografts represent the first choice for most reconstructive solutions, either as a structural buttress or impacted bone chips. Even though fresh-frozen bone is firmly recommended for structural grafts, freeze-dried and/or irradiated bone may be used alternatively for impaction grafting. Indeed, there are some papers on freeze-dried or irradiated bone impaction grafting, but their number is limited, as is the number of cases. Xenografts do not represent a viable option based on the poor available evidence but bioactive bioceramics such as hydroxyapatite and biphasic calcium phosphates are suitable bone graft extenders or even substitutes for acetabular impaction grafting. Bone-marrow-derived mesenchymal stem cells and demineralised bone matrix seem to act as reliable bone graft enhancers, i.e. adjuvant therapies able to improve the biological performance of standard bone grafts or substitutes. Among these therapies, platelet-rich plasma and bone morphogenetic proteins need to be investigated further before any recommendations can be made.Cite this article: EFORT Open Rev 2016;1:431-439. DOI:10.1302/2058-5241.160025
Community Participiation in Village Development: the Scale of Latvia
Authors: Pudzis Edgars , Geipele Sanda , Geipele Ineta 
Published: December 2016

Abstract
The research provides an insight into village development planning, as well as considers village planning from the perspective of the national planning framework. Local settings of village development have also been taken into account. The research provides information about possible approaches for local community involvement in development decision-making.
The article aims at considering the current situation of the involvement of local communities in the advancement of local territories and at presenting the proposals for public involvement models.
Analysis, logical and historical data access methods, induction and deduction have been used in the present research.
Capacity of Professional Specialists in Residential Housing Management in Latvia
Authors: Puķīte Iveta , Stāmure Iveta , Geipele Ineta 
Published: December 2016

AbstractThe issue of residential housing management, depending on the chosen form of the residential housing administration, is topical both from the perspective of residential building apartment owners, if apartment owners have chosen to manage the building themselves, and from the residential house manager’s point of view, if the management of the residential building has been entrusted to a professional manager. This is justified by the fact that the process of residential housing maintenance and management is based on knowledge, experience and financial resources; besides, it should be carried out by meeting the existing legislative requirements of the European Union and the Republic of Latvia, as well as the interests of the apartment owners.In Latvia, in order to manage a residential building, the administrator is required to have appropriate professional education, which, according to the Law of Residential Housing Management, should be at least the 4thlevel of Professional Qualification accepted in Latvia (the 5thlevel of European Qualifications Framework, EQK, and Latvian Qualifications Framework, LQK).The topicality of the study is related to the fact that in Latvia the law stipulates that a residential housing manager should have vocational education, which can be obtained at a number of public educational institutions. In the management process owners can choose their preferred management model, but right now the Register of the Ministry of Economics does not provide full information about the professionalism of an administrator. The goal of the study is determined by the topicality of the theme - to explore the existing models of residential housing management in the Latvian market and professional capacity of specialists involved in management. Within the framework of the study, statistical, qualitative and analytical methods have been used.As at present in Latvia there is no unified system for the accounting of housing management education in the market, the research results will contribute to its development and creation.
Honey Bee Infection Caused by Nosema spp. in Lithuania
Authors: Blažytė-Čereškienė Laima , Skrodenytė-Arbačiauskienė Vesta , Radžiutė Sandra , Nedveckytė Irena , Būda Vincas 
Published: December 2016

Abstract
The infection of Lithuanian honey bee colonies by Nosema apis and N. ceranae and the consequences were analysed over a four-year (2011 - 2014) period. Both mono-infection either by N. apis or N. ceranae, and co-infection by both Nosema species, were found. There was a decrease in the percentage of Nosema infected colonies during the four-year study period. There were fewer colonies infected by N. ceranae, whereas the number of colonies with N. apis remained approximately at the same level during the study. The prevalence of both types of Nosema in honey bee colonies varied seasonally, i.e. there was a higher percentage of colonies infected in spring and summer but very rarely was Nosema detected in autumn. Mono-infection by N. apis, and co-infection by both Nosema species, were significantly more often recorded in weak and moderate colonies than in strong colonies. Mono-infection by N. ceranae was more often detected in weak colonies than in moderate and strong colonies, but more often detected in strong than in moderate colonies. A moderate link between a high prevalence of N. ceranae infection and an increased risk for winter colony mortality was observed.