bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the burden of illness of haemophilia between resource‐constrained and unconstrained countries: the São Paulo–Toronto Hemophilia Study
Authors: Carneiro J. D. A. , Blanchette V. , Ozelo M. C. , Antunes S. V. , Villaca P. R. , Young N. L. , Castro D. , Brandão L. R. , Carcao M. , Abad A. , Feldman B. M. ,   the São Paulo–Toronto Hemophilia Study Group
Published: April 2017

IntroductionAlthough the regular replacement of clotting factor concentrates (prophylaxis) has been well established as the standard of care for severe haemophilia, the high cost of factor concentrates has limited access to prophylaxis in countries with under‐developed or developing economies.AimsWe studied the health gap that could be addressed by providing unlimited access to clotting factor concentrates with implementation of long‐term prophylaxis initiated from an early age in life.MethodsWe performed a cross‐sectional study of a random, representative sample of boys with moderate and severe haemophilia at three haemophilia treatment centres in Sao Paulo, Brazil, and one centre in Toronto, Canada.ResultsCanadian subjects were more often treated with prophylaxis, and began treatment at an earlier age. Fewer Canadian subjects had bleeds within the preceding 6 months (19 vs. 34, P = 0.003). Canadian subjects had lower (better) Pettersson radiographic scores (1.5 vs. 6.0, P = 0.0016), lower (better) Hemophilia Joint Health Scores (5.5 vs. 10.5, P = 0.0038), higher (better) Activity Scale for Kids scores (96.6 vs. 92.0, P = 0.033), more time spent in vigorous activity, and higher (better) social participation scores.ConclusionsOur findings suggest that increasing access to clotting factor concentrates for young boys with severe haemophilia is a global imperative.
Health information practice: integrating, inspiring and innovating
Authors: Marshall Audrey 
Published: April 2017

AbstractThe 2017 virtual issue of the Health Information and Libraries Journal (HILJ) is published to link to the 12th International Congress on Medical Librarianship and the 2017 EAHIL Workshop taking place in Dublin, Ireland on 12–16 June 2017. The conference title is Diversity in Practice: integrating, inspiring and innovative and it is exploring how health science librarianship, in all its diversity, is integrating, inspiring and innovating practice. These themes have been used to compile this virtual issue, which contains published articles selected from HILJ from the June 2014 issue through to September 2016. The virtual issue mirrors the format of a regular issue of HILJ, namely a review article, six original articles and our three regular features: ‘Dissertations into Practice’, ‘International Perspectives and Initiatives’ and ‘Teaching and Learning in Action’. All articles included in this virtual issue are available free online.
Regenerative endodontic treatment of perforated internal root resorption: a case report
Authors: Kaval M. E. , Güneri P. , Çalışkan M. K. 
Published: April 2017

AbstractAimTo present the regenerative endodontic treatment procedure of a perforated internal root resorption case and its clinical and radiographic findings after 2 years.SummaryA 14‐year‐old female patient was referred complaining of moderate pain associated with her maxillary left lateral incisor. After radiographic examination, a perforated internal resorption lesion in the middle third of tooth 22 was detected. Under local anaesthesia and rubber dam isolation, an access cavity was prepared and the root canal was shaped using K‐files under copious irrigation with 1% NaOCl, 17% EDTA and distilled water. At the end of the first and second appointments, calcium hydroxide (CH) paste was placed in the root canal using a lentulo. After 3 months, the CH paste was removed using 1% NaOCl and 17% EDTA solutions and bleeding in the root canal was achieved by placing a size 20 K‐file into the periapical tissues. Mineral trioxide aggregate was then placed over the blood clot. The access cavity was restored using glass–ionomer cement and resin composite. After 2 years, the tooth was asymptomatic and radiographic examination revealed hard tissue formation in the perforated resorption area and remodelling of the root surface.Key learning points

Regenerative endodontic treatment procedures are an alternative approach to treat perforated internal root resorption lesions.

Calcium hydroxide was effective as an intracanal medicament in regenerative endodontic treatment procedures.
Synthesis, characterization, and optimization of α‐Fe2O3/silica nanocomposites using homogenous precipitation method
Authors: Tari Faeze , Shekarriz Marzieh , Zarrinpashne Saeed , Ruzbehani Ahmad 
Published: April 2017

AbstractThe purpose of this study was to systematically synthesize and characterize the high surface area 10 wt% nanocomposites of α‐Fe2O3 (hematite)/silica using a simple and economically effective homogenous precipitation (HP) route via Response Surface Method combined with Central Composite Design (CCD). Accordingly, the RSM‐CCD approach including 20 experiments was designed to investigate the effects of three factors including concentration of iron chloride solution, pH and calcinations temperature on the final surface area of α‐Fe2O3/silica nanocomposites. The optimum surface area was 373 m2/g at the condition including iron chloride concentration of 0.018 mol/L, pH=8.95, and calcination temperature of 573°C.
Effects of BiMO3 on dielectric, ferroelectric, and piezoelectric properties of perovskite lead‐free piezoelectric BaTiO3–(Bi0.5Na0.5)TiO3 ceramics
Authors: Chaiyo Nopsiri , Muanghlua Rangson , Vittayakorn Wanwilai , Vittayakorn Naratip 
Published: April 2017

AbstractNew lead‐free piezoelectric ceramics of 0.9BaTiO3–(0.1−x)(Bi0.5Na0.5)TiO3–xBiMO3, M=Al and Ga, where x=0.00‐0.10, were fabricated by the solid‐state reaction technique. The effect of BiMO3 contents on the perovskite structure, phase transition, and dielectric, ferroelectric, and piezoelectric properties was investigated. X‐ray diffraction patterns showed that the ceramics exhibit a monophasic perovskite phase up to x=0.06, suggesting stabilized perovskite structures with B‐site aliovalent substitutions. Compositional‐dependent phase transitions were observed from tetragonal to pseudo‐cubic phase with increasing BiMO3 amounts. Al3+ ions were found to stabilize the transition temperature of the ceramics, while significantly decreasing transition temperature, and a change in the dielectric peak were found with an increasing amount of Ga3+. Regarding Al3+ substitution, the remanent polarization (Pr) values were found to decrease slightly with the Al3+ amount. With regard to Ga3+ substitution, Pr values decreased with the Ga3+ amount up to 0.06 and then increased slightly. The ceramics became softer with a higher degree of substitution according to the lower coercive field (Ec), when compared with 0.9BaTiO3–0.1(Bi0.5Na0.5)TiO3 ceramics. Ceramics with a lower degree of substitution and tetragonal phase showed butterfly strain loops that correlated with normal ferroelectric behavior.
Biodegradable hydrogel‐based biomaterials with high absorbent properties for non‐adherent wound dressing
Authors: Kumar Alok , Wang Xiang , Nune Krishna Chaitanya , Misra RDK 
Published: April 2017

ABSTRACTDressing materials involve conventional gauzes and modern materials such as hydrogels and foam‐based biomaterials. Although the choice of dressing material depends on the type of wound, a dressing material is expected to be non‐cytotoxic. Additionally, moist dressing is considered appropriate to accelerate epithelialisation, while dry dressing may cause tissue damage during removal. An ideal dressing material is expected to provide a moist environment and degrade and release the drug for faster wound healing. Thus, we have designed a hydrogel‐based biodegradable dressing material to provide the moist environment with no cytotoxic effect in vitro. The design of the hydrogel involved alginate–collagen reinforced with whisker cellulose derived from cotton. The hydrogel was prepared via amide linkage in the presence of 1‐ethyl‐(dimethylaminopropyl) carbodiimide (EDC) and N‐hydroxysulfosuccinimide (NHS), followed by divalent cationic cross‐linking of alginate and hydrogen bonding with cellulose. The high water retention capability of the hydrogel enables a moist environment to be maintained in the wounded area. The constituents of the hydrogel provided a microenvironment that was suitable for cell proliferation in the vicinity of the hydrogel but inhibited cell attachment on it. The MTT assay results indicated a higher fibroblast proliferation and viability in the presence of the hydrogel.
Understanding the solidification of stainless steel slag and dust mixtures
Authors: Jung Sung Suk , Kim Gi Beom , Sohn Il 
Published: April 2017

AbstractThe solidification of a multicomponent stainless steel slag and dust composite has been studied by thermodynamic calculations using Factsage and analyses of samples using EPMA and Rietveld refinement of synchrotron X‐ray powder diffraction after various cooling rates. At an apparent cooling rate of 1 K/min, the content of spinel (10.6 wt%) was less than thermodynamically calculated (16.6 wt%), largely because of difficulties in the diffusion of depleted ions (including Cr, Mn, and Ni) in the liquid with very gradual compositional gradients. Melilite showed a uniform but distorted crystal structure of P21212 and its content (48.9 wt%) was larger than the calculated result (32.3 wt%). At apparent cooling rates of 10 K/min and 50 K/min, a slight decrease in spinel and a significant decrease in melilite were observed, and the spinel was divided into two regions with an identical space group of Fdm but with distinguished composition and lattice parameters. However, the amorphous proportion consistently increased with the cooling rate from 29.4 wt% at 1 K/min to 69.6 and 92.9 wt% at 10 K/min and 50 K/min respectively.
Think manager—think male, think follower—think female: Gender bias in implicit followership theories
Authors: Braun Stephan , Stegmann Sebastian , Hernandez Bark Alina S. , Junker Nina M. , van Dick Rolf 
Published: April 2017

AbstractBecause of the overlap between the social roles of women and followers, we predicted that people would show a bias, that is, favor female followers over male followers. To support this hypothesis, we conducted two studies: An explicit test of the bias using a scenario design and an implicit association test (IAT)‐based study. Both studies show that the role of an ideal follower is more strongly associated with the female gender role, which seems to be caused partly by a more communal connotation of the follower role. This effect might contribute to the underrepresentation of women in leadership positions as they are perceived to be an ideal fit for followership positions; but it may also push men away from being followers and into leadership positions.
Efficacy and safety of twice‐ vs once‐daily dosing of lisinopril for hypertension
Authors: Tsai Tiffany , Kroehl Miranda E. , Smith Steven M. , Thompson Angela M. , Dai Isabella Y. , Trinkley Katy E. 
Published: April 2017

This retrospective cohort study compared administration of lisinopril twice daily and once daily for hypertension. Data were collected from an ambulatory electronic health record between 2011 and 2014. Patients previously receiving lisinopril 20 mg were placed into the once‐daily cohort if changed to 40 mg once daily or into the twice‐daily cohort if changed to 20 mg twice daily. Efficacy outcome measures were change in systolic blood pressure and diastolic blood pressure and achievement of blood pressure control (<140/90 mm Hg). Of 90 patients included (45 per cohort), the mean age was 61.8 years and 17.8% were black. Once‐ and twice‐daily administrations were associated with blood pressure reductions of 6.2/1.5 mm Hg and 16.5/5.9 mm Hg, with a 10.2/4.3 mm Hg greater reduction with twice‐daily administration (systolic blood pressure, P=.016; diastolic blood pressure, P=.068). Twice‐daily lisinopril dosing was associated with greater systolic blood pressure reductions compared with the same total daily dose administered once daily.
Comparison of direct sequencing and Invader assay for Y93H mutation and response to interferon‐free therapy in hepatitis C virus genotype 1b
Authors: Hayashi Kazuhiko , Ishigami Masatoshi , Ishizu Yoji , Kuzuya Teiji , Honda Takashi , Kawashima Hiroki , Ishikawa Tetsuya , Tachi Yoshihiko , Hattori Masashi , Katano Yoshiaki , Goto Hidemi , Hirooka Yoshiki 
Published: April 2017

AbstractBackground and AimVirologic failure of interferon‐free therapy has been associated with Y93H mutation in the non‐structure 5A region in hepatitis C virus (HCV) genotype 1b, and screening is recommended. A simple assay based on Q‐Invader technology was developed for Y93H mutant screening to reduce cost and effort. The present study sought to compare two methods of detection of Y93H mutation and to evaluate the effect of Y93H mutation on response to interferon‐free therapy.MethodsY93H mutation was examined in 258 patients with HCV genotype 1b using both direct sequencing analysis and the polymerase chain reaction (PCR)‐Invader assay. Daclatasvir and asunaprevir or ledipasvir and sofosbuvir therapy was administered to 205 patients whose sustained virological responses (SVR) were checked.ResultsHepatitis C virus was detected in 232 of 258 patients by direct sequencing and in 236 of 258 patients by the PCR‐Invader assay. Forty of 231 cases were defined as Y93 mutation by direct sequencing, and 46 of 236 cases were defined as Y93 mutation by the PCR‐Invader assay. SVR of patients who were Y93H by direct sequencing, Y93H by the PCR‐Invader assay, and Y93H by both methods was 62.5%, 82.4%, and 50%, respectively.ConclusionsThe sensitivity of the PCR‐Invader assay was similar to that of direct sequencing analysis; however, the PCR‐Invader assay had a better ability to detect minor strains. Combination of the two assays would improve prediction of the response to daclatasvir and asunaprevir, but Y93H mutation had little effect on SVR in ledipasvir and sofosbuvir therapy.
Herpes B virus replication and viral lesions in the liver of a cynomolgus macaque which died from severe disease with rapid onset
Authors: Pöhlmann Stefan , Suntz Michael , Akimkin Valerij , Bleyer Martina , Kaul Artur 
Published: April 2017

AbstractHerpes B virus (BV, Macacine alphaherpesvirus 1) infects macaques asymptomatically, with rare exceptions, but can cause fatal encephalitis in humans. Here, we report disseminated BV infection in a cynomolgus macaque that had died within 12 hour after the onset of unspecific symptoms. Multifocal lesions surrounded by viral antigen were detected in liver while other organs remained inconspicuous, indicating that the liver is a major target. Moreover, high copy numbers of viral DNA were found in feces, underlining the excrements are a potential source of transmission.
Mitochondrial biogenesis and PGC‐1α gene expression in male broilers from ascites‐susceptible and ‐resistant lines
Authors: Khodambashi Emami N. , Golian A. , Danesh Mesgaran M. , Anthony N. B. , Rhoads D. D. 
Published: April 2017

SummaryAscites is a cardiovascular metabolic disease characterized by accumulation of fluid around the heart and in the abdominal cavity that eventually leads to death. This syndrome is the end‐point result of a series of metabolic incidents that are generally caused by impaired oxygen availability. Mitochondria are the major sites of oxygen consumption, therefore major contributors to oxidative stress. Genetic, metabolic and dietary factors can influence variations in mitochondrial biogenesis (mitochondrial size, number and mass) that might have an effect on oxygen consumption and reactive oxygen species production. This study evaluated the effect of genotype on PGC‐1α mRNA gene expression and mitochondrial biogenesis. These parameters were examined in male broiler chickens at 22 weeks of age from the SUS and RES lines divergently selected for ascites phenotype. From each line, five birds were sampled for right ventricle and breast muscle. Gene expression and mtDNA copy number were assessed by quantitative PCR. Results showed that birds from SUS had significantly higher PGC‐1α mRNA gene (p = .033) and mitochondrial DNA copy number (p = .038) in breast muscle. There was no difference in right ventricle PGC‐1α expression or mitochondrial DNA copy number between the two lines. These findings indicate that mitochondrial biogenesis and PGC‐1α mRNA gene expression differ between male broiler chickens from RES and SUS lines in a tissue‐specific manner.
Divergence between riparian seed banks and standing vegetation increases along successional trajectories
Authors: Bourgeois Bérenger , Boutin Céline , Vanasse Anne , Poulin Monique 
Published: April 2017

AbstractQuestionsPlant community resilience largely depends on the secondary succession induced by species re‐colonization from seed banks. Soil seed bank resilience is, however, poorly understood, especially in regularly disturbed habitats like riparian zones. Two questions were asked: (1) what are the changes in species diversity experienced by riparian soil seed banks along successional trajectories, and (2) to what extent do riparian soil seed banks promote vegetation resilience during secondary succession?LocationSoutheast Quebec, Canada.MethodsSoils were collected along five rivers in field edges and riverbanks of post‐agricultural riparian zones with three contrasting successional stages (unplanted, planted with trees 15–17 yr prior to sampling, natural riparian forests), and their seed bank composition determined with the seedling emergence method. Species richness in seed banks was assessed along successional trajectories for distinct ecological groups, using LMM. The compositions of soil seed banks and standing vegetation (from botanical surveys) were compared based on NMDS and indicator species analysis.ResultsSeed bank species richness decreased along successional trajectories. Tree‐planted riparian zones were generally closer to unplanted riparian zones than to natural riparian forests, the latter being more species‐rich for natives, trees, shrubs and zoochores, and species‐poor for exotics, forbs and stress‐tolerators. Likewise, seed bank species composition of unplanted and tree‐planted riparian zones was similar but differed from that of natural riparian forests. Conversely, standing vegetation of tree‐planted riparian zones was intermediate between early and late successional stages, at least at field edges. For the three successional stages, seed bank composition clearly differed from standing vegetation.ConclusionsThe high resilience of riparian plant communities appeared poorly related to the dynamics of their soil seed banks. This species shift between seed banks and standing vegetation during secondary succession is likely due to periodic flooding, leading to the regular turnover of seeds. The resilience of riparian communities might thus be more influenced by spatial dispersal along rivers and across landscapes than by in situ temporal dispersal in soils.
Effects of an EP2 and EP3 Receptor Dual Agonist, ONO‐8055, on a Radical Hysterectomy‐Induced Underactive Bladder Model in Monkeys
Authors: MATSUYA Hidekazu , SEKIDO Noritoshi , KIDA Jun , MASHIMO Hiroko , WAKAMATSU Daisuke , OKADA Hiroki 
Published: April 2017

ObjectivesThe objective was to develop an underactive bladder (UAB) model in primates and to evaluate the potential of prostanoid EP2 and EP3 receptor dual agonist ONO‐8055 to become a therapeutic agent for UAB.MethodsA surgical procedure resembling radical hysterectomy was performed on female cynomolgus monkeys. Subsequently, in vitro muscle strip studies were performed using bladder muscle strips from normal monkeys and monkeys that underwent surgery. In addition, uroflowmetric data were obtained at specified days after the surgery. To evaluate the effects of ONO‐8055 and distigmine (DIS) on voiding function in the UAB monkey model, uroflowmetry was performed approximately 1 week after the surgery, before and after the cumulative intravenous administration of the compounds at 2 h intervals.ResultsIn the bladder muscle strip studies, the responses to potassium chloride at 2 months, and carbachol and electrical field stimulation from 2 weeks decreased significantly. Voided volume (VV), maximum flow rate (Qmax), and average flow rate (Qave) decreased after surgery, while voiding time (VT) increased. In this model, ONO‐8055 and DIS significantly increased VV and Qmax. DIS prolonged VT, while ONO‐8055 had no effect. The results also showed that ONO‐8055 increased Qave.ConclusionsWe developed a neurogenic UAB model in primates. As ONO‐8055 improved voiding function in this model to at least the same degree as DIS, this EP2 and EP3 receptor dual agonist has the potential to be a candidate for neurogenic UAB pharmacotherapy.
Competent or Competitive? How Employee Representatives Gain Influence in Organizational Decision‐Making
Authors: García Ana Belén , Munduate Lourdes , Elgoibar Patricia , Wendt Hein , Euwema Martin 
Published: April 2017

AbstractConflicts of interest between management and employees are part of organizational life. To manage these conflicts, employee representatives (ERs) often participate in organizational decision‐making. The objectives of this article were to investigate the relation between perceived competences of ERs and their influence on organizational decision‐making in different types of issues, and the mediating effect of ERs’ conflict behaviors on these relations. To test the hypotheses, which are based on theories of power and conglomerate conflict behavior, survey data from 614 human resources directors from 11 European countries were analyzed using structural equation modeling. Results show that perceived competences are positively related to the influence of ERs on decision‐making, both for traditional and for innovative issues. Perceived competence is positively related to cooperative and negatively related to competitive conflict behavior. Conglomerate conflict behavior partly mediates the relation between perceived competences and influence. Implications for representative influence are discussed.