bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative ultrasonographic evaluation of intrarenal artery resistive index among hypertensive and normotensive adults in a black African population compared to a European population
Authors: Madubueze George , Ugwa Emmanuel 
Published: January 2018

Background Hypertensive nephropathy is an important medical problem among the black African population. Early detection of renovascular changes using ultrasonography can provide opportunity for immediate intervention towards preventing or at least delaying the irreversible hypertensive nephropathy. Purpose To compare intrarenal resistive index (RI) in healthy normotensive and hypertensive adults in Kano, Nigeria. Material and Methods A prospective comparative study of intrarenal RI using ultrasound in 150 hypertensives and 150 normotensive controls. The mean renal RI of the interlobar arteries of both kidneys were measured and recorded. The data were analyzed with the aid of computer-based SPSS 16.0 software for Windows. Results The age range of the study participants was 35–70 years. The mean interlobar artery RI values were 0.59 ± 0.04 and 0.59 ± 0.03 on the right and left sides, respectively, in normotensive control individuals while those of hypertensive individuals were 0.73 ± 0.03 and 0.73 ± 0.03 for the mean interlobar artery RI values on the right and left sides, respectively. Conclusion The intrarenal RIs were lower in normotensives when compared with the hypertensive participants, which were statistically significant. These showed that hypertension has significant effects on the kidneys, and with early detection and intervention, irreversible renal damage may be prevented.
Documentation of Contraception and Pregnancy Intention In Medicaid Managed Care
Authors: Thiel de Bocanegra Heike , McKean Alia , Darney Philip , Saleeby Erin , Hulett Denis 
Published: January 2018

Context: Clinical guidelines recommend the documentation of pregnancy intention and family planning needs during primary care visits. Prior to the 2014 Medicaid expansion and release of these guidelines, the documentation practices of Medicaid managed care providers are unknown. Methods: We performed a chart review of 1054 Medicaid managed care visits of women aged 13 to 49 to explore client, provider, and visit characteristics associated with documentation of immediate or future plans for having children and contraceptive method use. Five managed care plans used Current Procedural Terminology and International Classification of Diseases, Ninth Revision codes to identify providers with at least 15 women who had received family planning or well-woman care in 2013. We conducted multilevel logistic regression analyses with documentation of contraceptive method and pregnancy intention as outcome variables and clinic site as the level 2 random effect. Results: Only 12% of charts had documentation of pregnancy intention and 59% documented contraceptive use. Compared to women with a family planning visit reason, women with an annual, reproductive health, or primary care reason for their visit were significantly less likely to have contraception documented (odds ratio [OR] = 11.0; 95% confidence interval [CI] = 6.8-17.7). Age was also a significant predictor with women aged 30 to 49 (OR = 0.6; 95% CI = 0.4-0.9), and women aged 13 to 19 (OR = 0.2; 95% CI = 0.1-0.6) being less likely to have a note about pregnancy intention in their chart. Pregnancy intention was more likely to be documented in multispecialty clinics (OR = 15.5; 95% CI = 2.7-89.2). Conclusions: Interventions to improve routine medical record documentation of contraception and pregnancy intention regardless of patient age and visit characteristics are needed to facilitate the provision of family planning in managed care visits and, ultimately, achieving better maternal infant health outcomes and reduced costs.
Naive Expectations to Resignation
Authors: Evans Michael M , Hupcey Judith E , Kitko Lisa , Alonso Windy 
Published: January 2018

Purpose: This study examined life descriptions of persons with stage D heart failure (HF) comparing those newly diagnosed to those with chronic HF. Methods: A secondary analysis of interviews from 75 participants followed in a longitudinal study of persons with stage D HF was thematically analyzed. There were 24 participants who were recently diagnosed with stage D HF (less than 2 years) and 51 participants with HF longer than 2 years. Results: Both groups shared life descriptions along a continuum, where recently diagnosed participants described naive expectations with hope for improvement, while the chronic group appeared resigned to their fate and the reality of the limitations of living with HF. Four themes illustrated differences between the groups: outlook on life, activity adjustments, understanding of HF, and mood. Conclusions: Although persons with stage D HF share the same life descriptions, they have differing perspectives of life with HF. Findings from this study can help health-care providers tailor interventions based on the length of time from diagnosis.
Relationship Between Claims Data and the Preferences and Trends Survey: An Analysis of Anti-Vascular Endothelial Growth Factor Medication Choice for Age-Related Macular Degeneration
Authors: Parikh Ravi , Feng Paula W. , Del Priore Lucian V. , Adelman Ron A. , Chaudhry Nauman A. 
Published: January 2018

Purpose: To compare published self-reported practice patterns among retina specialists with published claims data representing actual practice patterns for the use of anti-vascular endothelial growth factor (anti-VEGF) medications in the treatment of age-related macular degeneration (AMD) in the United States. Methods: We compared physician self-reported preference for anti-VEGF medications to treat AMD in the American Society of Retina Specialists’ Preferences and Trends (PAT) survey with a previously published study using claims data from 2006 to 2015 from OptumLabs Data Warehouse as a data source. A Pearson χ2 test compared the relative proportions of drug use between the 2 groups, with <.05 indicating statistical significance. Results: From 2006 to 2015, the PAT surveys had approximately 3548 respondents to questions on which anti-VEGF medication was used for the treatment of AMD. Over the study period, 62.3% (2211/3548) of respondents preferred bevacizumab, 30.4% (1078/3548) ranibizumab, and 7.3% (259/3548) aflibercept in the treatment of AMD. Claims data on anti-VEGF use for AMD noted 59.7% (359 267/601 917) of injections were for bevacizumab, 23.8% (143 200/601 917) were for ranibizumab, and 16.5% (99 450/601 917) were for aflibercept. The difference in the relative use of bevacizumab, ranibizumab, and aflibercept use was not significant between the data sets ( P = .1991). Conclusions: The PAT survey responses appear to reflect actual physician practices based upon claims data and demonstrate the prevalence of bevacizumab as the prevailing treatment for AMD.
Inference of Germline Mutational Status and Evaluation of Loss of Heterozygosity in High-Depth, Tumor-Only Sequencing Data
Authors: Khiabanian Hossein , Hirshfield Kim M. , Goldfinger Mendel , Bird Simon , Stein Mark , Aisner Joseph , Toppmeyer Deborah , Wong Serena , Chan Nancy , Dhar Kalyani , Gheeya Jinesh , Vig Hetal , Hadigol Mohammad , Pavlick Dean , Ansari Sepand , Ali Siraj , Xia Bing , Rodriguez-Rodriguez Lorna , Ganesan Shridar 
Published: January 2018

Purpose Inherited germline defects are implicated in up to 10% of human tumors, with particularly well-known roles in breast and ovarian cancers that harbor BRCA1/2-mutated genes. There is also increasing evidence for the role of germline alterations in other malignancies such as colon and pancreatic cancers. Mutations in familial cancer genes can be detected by high-throughput sequencing, when applied to formalin-fixed paraffin-embedded tumor specimens. However, because of the frequent lack of patient-matched control normal DNA and/or low tumor purity, there is limited ability to determine the genomic status of these alterations (germline v somatic) and to assess the presence of loss of heterozygosity (LOH). These analyses, especially when applied to genes such as BRCA1/2, can have significant clinical implications for patient care. Materials and Methods LOHGIC (LOH-germline inference calculator) is a statistical model selection method to determine somatic versus germline status and predict LOH for mutations identified via clinical grade, high-depth, hybrid capture, tumor-only sequencing. LOHGIC incorporates statistical uncertainties inherent to high-throughput sequencing as well as specimen biases in tumor purity estimates, which we used to assess BRCA1/2 mutations in 1,636 specimens sequenced at Rutgers Cancer Institute of New Jersey. Results Evaluation of LOHGIC with available germline sequencing from BRCA1/2 testing demonstrates 93% accuracy, 100% precision, and 96% recall. This analysis highlights a differential tumor spectrum associated with BRCA1/2 mutations. Conclusion LOHGIC can assess LOH status for both germline and somatic mutations. It also can be applied to any gene with candidate, inherited mutations. This approach demonstrates the clinical utility of targeted sequencing in both identifying patients with potential germline alterations in tumor suppressor genes as well as estimating LOH occurrence in cancer cells, which may confer therapeutic relevance.
Effectiveness and safety of CT-guided percutaneous radiofrequency ablation of adrenal metastases
Authors: Zhou Kang , Pan Jie , Yang Ning , Shi Hai-Feng , Cao Jian , Li Yu-Mei , Zhang Hong-Zhi , Wang Ke-Fei , Chen Shao-Hui 
Published: January 2018

Objective:
The imaging-guided percutaneous radiofrequency (RF) ablation of adrenal metastases is a relatively new treatment procedure, compared to the more widespread application of the technique for the treatment of liver and renal cancers. The present study aims to evaluate the safety and efficacy of the CT-guided percutaneous RF ablation of adrenal metastases in a cohort of patients.

Methods:
33 patients with 38 adrenal metastases who received percutaneous CT-guided RF ablation between 2012 to 2015 were retrospectively reviewed. The average diameter of the treated adrenal metastases was 3.0 ± 1.6 cm. The treatment outcomes, including presence of residual tumours, technical success rate, recurrence rate, and complications, were evaluated. Patients were followed up for every 3 months to monitor the progression of the disease.

Results:
Postoperative CT images showed the lack of tumour enhancement in 30 tumours (30/38 tumours, technical success rate = 78.9%), and residual disease was found in 7 tumours (7/37 tumours, 18.9%). The rate of residual disease was significantly lower in the group with tumour size &lt;3 cm than the group with tumour size ≥3 cm (p = 0.025). The severe complication rate was 4.3%, and the mild complication rate was 48%, with intraoperative hypertensive crisis as the most frequently observed complication (27.3%). The follow-up data showed that 76.3% of patients had recurrence-free survival in 27.4 months.

Conclusion:
The current study demonstrated that radiofrequency ablation is a relatively safe and effective treatment for controlling adrenal metastases, especially for patients with tumour size &lt;3 cm.

Advances in knowledge:
Surgical resection of the adrenal metastases was advocated as one of the treatment options for patients. The present study showed that radiofrequency ablation is a relatively safe and effective treatment for controlling adrenal metastases.
Treatment of the overriding fifth toe: Butler's arthroplasty is a good option
Authors: Simões R. , Alves C. , Tavares L. , Balacó I. , Cardoso P. Sá , Ling T. Pu , Matos G. 
Published: January 2018

Purpose The overriding fifth toe is a congenital triplane deformity that may cause aesthetic and functional concerns in children and adolescents. This study aims to evaluate the results obtained when using Butler's arthroplasty to treat this forefoot deformity. Methods We performed a retrospective study, including all patients undergoing Butler's arthroplasty from January 1995 to December 2012. Clinical records were reviewed to determine age at date of surgery, gender, laterality, preoperative symptoms, success of deformity correction, postoperative pain, scarring, need for adapted shoe, rates of complications and recurrence. Patient satisfaction was evaluated through a telephone interview. All p-values < 0.05 were considered statistically significant. Results A total of 21 patients were included in this study, the majority of which were male (57%), with a mean follow-up of 12 months (1 to 52). In the evaluation of the residual deformity (18 patients), 72% had excellent results, 17% good and 11% poor results. One patient had a keloid scar, three patients reported pain and three patients required adapted footwear. There was a partial recurrence of the deformity in three cases. The majority of patients (78%) were satisfied with the surgery. There was no statistically significant difference in terms of results, when comparing patients older and younger than seven years of age (p = 0.46). Conclusions Butler's operation is effective and safe in the treatment of the overriding fifth toe, yielding good functional results and patient satisfaction, with low rate of complications. Level of Evidence IV
Relationship between thoracic kyphosis and neural axis abnormalities in patients with adolescent idiopathic scoliosis
Authors: Swarup I. , Derman P. , Sheha E. , Nguyen J. , Blanco J. , Widmann R. 
Published: January 2018

Purpose Previous studies have suggested an association between increased thoracic kyphosis and neural axis abnormalities in patients with adolescent idiopathic scoliosis (AIS). However, the basis for this finding is unclear, and this association has been mainly noted in retrospective studies on a non-consecutive series of patients. The purpose of this study was to assess the relationship between thoracic kyphosis and neural axis abnormalities in patients with AIS. Methods We studied a consecutive series of AIS patients treated with spinal fusion. Thoracic kyphosis (T2 to T12) was measured from preoperative lateral radiographs. All patients underwent a spine magnetic resonance imaging (MRI) prior to surgery, and MRI reports were reviewed to determine the presence of neural axis abnormalities. Statistical analyses included descriptive statistics and chi-squared analysis. Results This study included 210 patients with AIS. There were no significant differences in age or gender between patients with thoracic hypokyphosis (kyphosis < 20°), normal thoracic kyphosis (kyphosis 20° to 40°) and thoracic hyperkyphosis (kyphosis > 40°) (p > 0.05). Neural axis abnormalities were present in 17.9% of patients with thoracic hypokyphosis, 9.8% of patients with normal thoracic kyphosis and 13.6% of patients with thoracic hyperkyphosis (p = 0.60). There were no significant differences in rates of Chiari malformation, syrinx, intra-spinal masses and other central nervous system abnormalities between groups (p > 0.05). Conclusions Thoracic kyphosis was not associated with neural axis abnormalities in our consecutive series of patients with AIS. Increased thoracic kyphosis may not be a reliable indicator for the presence of neural axis abnormalities in patients with AIS. Level of Evidence IV
THE ISLAMIC EDUCATIONAL VALUES IN THE PUPPETRY (Study on the story of Cungkring Takon Suwarga by Dalang Amudy Nata Prawa Cirebon West Jawa)
Authors: SA Nurul Huda , Faridah Lili 
Published: January 2018

This research aims to find out: the message, the value of any Islamic education embodied in the story of Cungkring asks Suwarga and the story’s position in relation to the context of people's lives today. Research has found that there are three aspects of the message and Islamic educationa values in the story of Cungkring asks Suwarga created by puppeteer Amudy Nata Prawa. Islamic educational values that include first, the value of worship (worship to Allah), includes transcendenta worship (Ibadah Mahdhoh), the confession (Syahadat) and pray (Shalat). Secondly, social worship. Third, the universal value of education. The Position of the story of cungkring takon Suwarga and its relationship with public life today is able to become an awareness for the media and a reminder of human life after death (tadzkiratul maut) in terms of awareness about life in the hereafter. Message and Islamic educational value contained in the play Cungkring asks Suwarga can be used as a reference for parents and educators to teach Islamic education values to children. Such as education about tolerance, cooperation, honesty, modesty, loyalty, love, responsibility and so on.
A Discourse of Transformative Islam within Curriculum Transformation at State Institute for Islamic Studies of Purwokerto (IAIN Purwokerto)
Authors: Sabarudin Sabarudin 
Published: January 2018

Abstract
This research is aimed to trace the thoughts and actions as efforts to achieve vision and mission of state institute for Islamic studies of Purwokerto (IAIN). The study is directed to answer following questions. Firstly, why transformative Islam becomes a discourse on curriculum development. Secondly, how a discourse of transformative Islam implicates in curriculum development at state institute for Islamic studies of Purwokerto (IAIN). Then, the findings show that a discourse of Islam tranformative in curriculum development at state institute for Islamic studies of Purwokerto (IAIN) emerges as a result of an incapability of traditional and modern Islam perspective to resolve people’s problem due to lack of critical understanding of the meaning and message of the Qur’an and Hadith. Then, implication of Islamic transformative discourse in curriculum development at state institute for Islamic studies of Purwokerto can be seen in its intra curricular activities, co-curricular, and extra curricular activities. Through intra-curricular activities, transformative Islam is embodied in Islamic building lectures. In co-curricular program, Islam is indigenized through activity of knowledge and practice of worship (nationally abbreviated PPI), while within extra-curricular activities transformative Islamic values come into student activities which are strongly supported by policies of university leaders.
Keywords: Transformative Islam, Islamic Building, Knowledge and Practice of Worship
Abstrak
Tujuan penelitian ini adalah untuk menelusuri pemikiran dan aksi dari upaya pencapaian visi dan misi IAIN Purwokerto. Petanyaan penelitiannya adalah pertama mengapa Islam transformatif menjadi wacana dalam pengembangan kurikulum. Kedua, bagaimana implikasi wacana Islam transformatif dalam pengembangan kurikulum di IAIN Purwokerto. Hasil penelitian menunjukkan, bahwa pertama, wacana Islam transformatif dalam pengembangan kurikulum IAIN Purwokerto muncul akibat ketidakmampuan pandangan tradisionalis dan modernis Islam dalam menyelesaikan persoalan umat akibat dari kurang kritisnya dalam menangkap makna dan pesan al-Qur’an dan al-Hadits. Kedua, Implikasi wacana Islam transformatif dalam pengembangan kurikulum di IAIN Purwokerto dapat dicermati pada kegiatan intra kurikuler, ko-kurikuler, dan ekstra kurikuler. Dalam bentuk intra kurikuler, Islam tranformatif mewujud dalam perkuliahan Islamic Building. Dalam kegiatan ko-kurikuler, Islam transformatif melalui bentuk pribumisasi Islam melalui kegiatan, Pengetahuan dan Pengamalan Ibadah (PPI). Sedangkan dalam kegiatan ekstra kurikuler, nilai-nilai Islam transformatif memperoleh lahan dalam kegiatan kemahasiswaan, yang mendapat dukungan kuat melalui kebijakan pimpinan.
Kata Kunci: Islam Transformatif, Islamic Building, Pengetahuan dan Pengamalan Ibadah
Transcriptional analysis of immune-relevant genes in the mucus of Labeo rohita, experimentally infected with Argulus siamensis
Authors: Parida Sonali , Mohapatra Amruta , Kar Banya , Mohanty Jyotirmaya , Sahoo Pramoda Kumar 
Published: January 2018

AbstractThe knowledge of mucosa-associated molecular events that occur during infections is scarce despite the well-established importance of mucus in fish immunity. Using qRT-PCR, we analyzed the immune gene expression patterns in mucus ofLabeo rohitaexperimentally infected with an ectoparasiteArgulus siamensis. Mucus samples were collected at 0 h, 12 h, 24 h, 3 d, 7 d, 15 d, and 30 d post challenge ofL.rohitawith metanauplii ofA.siamensis. All interleukins studied herein (IL 6, IL 15, and IL 1β) showed significant upregulation of expression levels in mucus ofA.siamensis-infected fish compared to control samples. Further, the expression levels of molecules involved in pathogen recognition, toll like receptor 22, and pathogen presentation, β2 microglobulin, were found to be significantly upregulated in experimental samples until 7 d post challenge compared to control samples. The upregulated expression of lysozyme G at all time points post infection indicated the early activation of acute phase responses in mucus of infectedL.rohita. Moreover, the expression levels of natural killer cell enhancing factor B were found to be higher in infected fish than they were in the control fish. The early upregulation of the immune genes observed herein reinforces the role of mucus as the first line of defense against pathogenic assault; furthermore, it expands our understanding of mucosal-immune responses toA.siamensisinfection, which can aid development of immunological interventions.
Nematode Thelazia callipaeda is spreading across Europe. The first survey of red foxes from Slovakia
Authors: Čabanová Viktória , Miterpáková Martina , Oravec Martin , Hurníková Zuzana , Jerg Slavomír , Nemčíková Gabriela , Červenská Michaela Brincko 
Published: January 2018

Abstract
Canine thalaziosis caused by the spirurid nematode Thelazia callipaeda has started to spread across Western and Central Europe during the last decade. In Slovakia, the first autochthonous cases of this infection were recorded in 2016 in four dogs from the south-eastern part of the country. In August 2017 other autochthonous case, again from the same locality, was reported. Seeing that red foxes are considered the main reservoir hosts for T. callipaeda, their examination could provide an integrated view of the real parasite distribution. Within the present study, 523 red foxes were examined by necropsy, and T. callipaeda nematodes were recovered from the conjunctival sacs of 7 animals, which represents an overall positivity of 1.3%. Six infected foxes originated in eastern Slovakia, which is consistent with the area where positive dogs were recently found. Also, single positive red fox was found in north-western Slovakia. Regarding morphology and morphometry, the specimens recovered from the foxes in this study were evaluated as larger in size when compared to nematodes isolated from Slovak dogs as well as dogs and foxes from other studies. BLAST analyses of the cox1 gene showed that all specimens isolated from Slovak red foxes were identified as haplotype 1 which circulated also in other European countries. Considering that majority of the infected animals, dogs and foxes, came from Košice region, we can presume that this area might become endemic in a short period of time.