bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal asymmetry and other motion parameters that characterise high-quality female dance
Authors: McCarty Kristofor , Darwin Hannah , Cornelissen Piers L. , Saxton Tamsin K. , Tovée Martin J. , Caplan Nick , Neave Nick 
Published: February 2017

AbstractDance is a universal human behaviour that is observed particularly in courtship contexts, and that provides information that could be useful to potential partners. Here, we use a data-driven approach to pinpoint the movements that discriminate female dance quality. Using 3D motion-capture we recorded women whilst they danced to a basic rhythm. Video clips of 39 resultant avatars were rated for dance quality, and those ratings were compared to quantitative measurements of the movement patterns using multi-level models. Three types of movement contributed independently to high-quality female dance: greater hip swing, more asymmetric movements of the thighs, and intermediate levels of asymmetric movements of the arms. Hip swing is a trait that identifies female movement, and the ability to move limbs asymmetrically (i.e. independently of the other) may attest to well-developed motor control, so long as this limb independence does not verge into uncontrolled pathological movement. We also found that the same level of dance quality could be predicted by different combinations of dance features. Our work opens avenues to exploring the functional significance, informational content, and temporal sequencing of the different types of movement in dance.
Comprehensive Proteomic Characterization of the Human Colorectal Carcinoma Reveals Signature Proteins and Perturbed Pathways
Authors: Hao Jian-Jiang , Zhi Xiaofei , Wang Yeming , Zhang Zheng , Hao Zeyu , Ye Rong , Tang Zhijie , Qian Fei , Wang Quhui , Zhu Jianwei 
Published: February 2017

AbstractThe global change in protein abundance in colorectal cancer (CRC) and its contribution to tumorigenesis have not been comprehensively analyzed. In this study, we conducted a comprehensive proteomic analysis of paired tumors and adjacent tissues (AT) using high-resolution Fourier-transform mass spectrometry and a novel algorithm of quantitative pathway analysis. 12380 proteins were identified and 740 proteins that presented a 4-fold change were considered a CRC proteomic signature. A significant pattern of changes in protein abundance was uncovered which consisted of an imbalance in protein abundance of inhibitory and activating regulators in key signal pathways, a significant elevation of proteins in chromatin modification, gene expression and DNA replication and damage repair, and a decreased expression of proteins responsible for core extracellular matrix architectures. Specifically, based on the relative abundance, we identified a panel of 11 proteins to distinguish CRC from AT. The protein that showed the greatest degree of overexpression in CRC compared to AT was Dipeptidase 1 (DPEP1). Knockdown of DPEP1 in SW480 and HCT116 cells significantly increased cell apoptosis and attenuated cell proliferation and invasion. Together, our results show one of largest dataset in CRC proteomic research and provide a molecular link from genomic abnormalities to the tumor phenotype.
Patterns of pollen and nectar foraging specialization by bumblebees over multiple timescales using RFID
Authors: Russell Avery L. , Morrison Sarah J. , Moschonas Eleni H. , Papaj Daniel R. 
Published: February 2017

AbstractThe ecological success of social insects is frequently ascribed to improvements in task performance due to division of labour amongst workers. While much research has focused on improvements associated with lifetime task specialization, members of colonies can specialize on a given task over shorter time periods. Eusocial bees in particular must collect pollen and nectar rewards to survive, but most workers appear to mix collection of both rewards over their lifetimes. We asked whether bumblebees specialize over timescales shorter than their lifetime. We also explored factors that govern such patterns, and asked whether reward specialists made more foraging bouts than generalists. In particular, we described antennal morphology and size of all foragers in a single colony and related these factors to each forager’s complete foraging history, obtained using radio frequency identification (RFID). Only a small proportion of foragers were lifetime specialists; nevertheless, >50% of foragers specialized daily on a given reward. Contrary to expectations, daily and lifetime reward specialists were not better foragers (being neither larger nor making more bouts); larger bees with more antennal olfactory sensilla made more bouts, but were not more specialized. We discuss causes and functions of short and long-term patterns of specialization for bumblebee colonies.
3D printed bandpass filters using compact high‐Q hemispherical resonators with improved out‐of‐band rejection
Authors: Li Jin , Guo Cheng , Mao Lijian , Xu Jun 
Published: February 2017

RF design and implementation of ceramic‐filled resin‐based 3D printed millimetre‐wave bandpass filters (BPFs) using a new class of compact high‐quality‐factor hemispherical cavity resonators are addressed. Design concept of the hemispherical resonator is discussed for BPF applications in both X and Ka bands. For validation purpose, the Ka‐band fourth‐order BPF is fabricated with a high‐temperature‐resistant ceramic‐filled resin using a fast and low‐cost stereolithography‐based 3D printing technique, and its surface metallisation is realised by employing electroless copper/silver plating. The proposed BPF's geometrical configuration contributes to a significantly improved out‐of‐band rejection. The RF‐measured results demonstrate the Ka‐band BPF an insertion loss of 0.43−0.9 dB from 31.52 to 32.42 GHz, a passband return loss mostly better than 15 dB, and a small frequency shift of about 0.06%.
Rapid Deterioration of Latent HBV Hepatitis during Cushing Disease and Posttraumatic Stress Disorder after Earthquake
Authors: Tashiro Ryosuke , Tominaga Teiji , Ogawa Yoshikazu 
Published: February 2017

AbstractReactivation of the hepatitis B virus (HBV) is a risk in the 350 million HBV carriers worldwide. HBV reactivation may cause hepatocellular carcinoma, cirrhosis, and fulminant hepatitis, and HBV reactivation accompanied with malignant tumor and/or chemotherapy is a critical problem for patients with chronic HBV infection. Multiple risk factors causing an immunosuppressive state can also induce HBV reactivation.We present a case of HBV reactivation during an immunosuppressive state caused by Cushing disease and physical and psychological stress after a disaster. A 47-year-old Japanese woman was an inactive HBV carrier until the Great East Japan Earthquake occurred and follow-up was discontinued. One year after the earthquake she had intractable hypertension, and her visual acuity gradually worsened. Head magnetic resonance imaging showed a sellar tumor compressing the optic chiasm, and hepatic dysfunction with HBV reactivation was identified. Endocrinologic examination established the diagnosis as Cushing disease. After normalization of hepatic dysfunction with antiviral therapy, transsphenoidal tumor removal was performed that resulted in subtotal removal except the right cavernous portion. Steroid hormone supplementation was discontinued after 3 days of administration, and gamma knife therapy was performed for the residual tumor. Eighteen months after the operation, adrenocorticotropic hormone and cortisol values returned to normal. The patient has been free from tumor regrowth and HBV reactivation throughout the postoperative course.Accomplishment of normalization with intrinsic steroid value with minimization of steroid supplementation should be established. Precise operative procedures and careful treatment planning are essential to avoid HBV reactivation in patients with this threatening condition.
Integration der Suchtmedizin ins Medizinstudium – interaktive Umgestaltung eines Seminars im Bereich Prävention und Gesundheitsförderung
Authors: Bleckwenn Markus , Just Johannes , Rüdisser Valeria , Engel Bettina , Weckbecker Klaus 
Published: February 2017

Zusammenfassung Durch eine interaktive Lehre konnte in Modellprojekten das suchtmedizinische Grundwissen bei Medizinstudenten in kurzer Zeit verbessert werden. Daher war das Ziel unseres Projektes, ein Seminar mit einem suchtmedizinischen Thema interaktiv zu gestalten und die Akzeptanz einer solchen Umgestaltung zu überprüfen.In ein Seminar über Medikamentenabhängigkeit wurden schrittweise aktivierende Lehrmethoden integriert. Dabei wurde pro Semester eine aktivierende Lehrmethode eingeführt. Anhand der Semesterevaluation wurde eine Lehrmethode im Seminarablauf belassen oder auch ausgetauscht. Nach der vollständigen interaktiven Umgestaltung wurde die Zufriedenheit von Studenten und deren Dozenten überprüft.Die 4 beteiligten Dozenten gaben eine hohe Zufriedenheit mit der Lehre im Seminar an [9,4 (0–10)]. Auch die Studenten (n=69) bewerteten das Seminar positiv (8,4) und bestätigten den hohen Grad an Interaktivität (8,1) und didaktischer Qualität (8,1).Eine interaktive Umgestaltung von Seminaren ist möglich. Aufgrund der positiven Ergebnisse ist aktive Lehre in Seminaren zu empfehlen.
Architected cellular ceramics with tailored stiffness via direct foam writing
Authors: Muth Joseph T. , Dixon Patrick G. , Woish Logan , Gibson Lorna J. , Lewis Jennifer A. 
Published: February 2017

Significance
Direct foam writing enables the construction of architected cellular ceramics with tailored microstructure, geometry, and mechanical properties. These bioinspired, hierarchical structures exhibit different modes of deformation as well as exceptional specific stiffness. This work represents an important step toward the scalable fabrication of architected porous materials, which may find potential application as lightweight structures, thermal insulation, tissue scaffolds, catalyst supports, and electrodes.
Spectrin βV adaptive mutations and changes in subcellular location correlate with emergence of hair cell electromotility in mammalians
Authors: Cortese Matteo , Papal Samantha , Pisciottano Francisco , Elgoyhen Ana Belén , Hardelin Jean-Pierre , Petit Christine , Franchini Lucia Florencia , El-Amraoui Aziz 
Published: February 2017

Significance
The mammalian auditory organ harbors a subpopulation of sensory hair cells that alternately shorten and elongate in response to sound stimuli. This singular feature, called somatic electromotility, is associated with the presence of a flexible cortical network of F-actin and spectrin βV, a large unconventional β-spectrin. We show that adaptive mutations of spectrin-βV occurred in the mammalian lineage and were accompanied with substantial changes in the protein distribution within inner ear hair cells. This study illustrates how a comparison of the subcellular locations of a protein between nonmammalian and mammalian vertebrates in a given cell type, combined with branch-site model analysis of the protein family in silico, can shed light on a major mammalian structural/functional innovation.
Mill’s act-utilitarian interpreters on Utilitarianism chapter V paragraph 14
Authors: Miller Dale E. 
Published: February 2017

AbstractIn the fourteenth paragraph of the fifth chapter of Utilitarianism, J. S. Mill writes that ‘We do not call anything wrong, unless we mean to imply that a person ought to be punished in some way or other for doing it; if not by law, by the opinion of his fellow-creatures; if not by opinion, by the reproaches of his own conscience.’ I criticize the attempts of three commentators who have recently presented act-utilitarian readings of Mill – Roger Crisp, David Brink, and Piers Norris Turner – to accommodate this passage.
Social actors and social ties in multiple modernity: Familism and social change in the South of Italy
Authors: Costabile Antonio , Coco Antonella 
Published: February 2017

ABSTRACT
This paper focuses on relationships between community ties and social change, highlighting family bonds in the South of Italy. We interrogate major results of contemporary research on political familism and its interconnections with political clientelism. The category of political familism highlights the presence of family chains within political parties, hence in the selection of the political class and within the bureaucratic sector. We argue that, in some contexts, the crisis of political parties in Italy and specific forms of personalisation of power are accompanied by the strengthening of political familism, since family ties still constitute a strategic resource for electoral and political success. Furthermore, we highlight firstly those factors which have favoured the persistence of familism, both in the private and in the public spheres, and subsequently some factors indicating crisis or change in the familistic model, in addition to its multiple ambivalences.
International Criminal Law and Its Paradoxes
Authors: Carlson Kerstin Bree 
Published: February 2017

AbstractThis article challenges international criminal tribunals’ (ICTs) capacity to perform the socially constitutive work of transitional justice. Highlighting paradigmatic ICT jurisprudence, I show that both the “progress” and “justice” constructs central to the work and legitimacy of international criminal law are unrealizable under current ICT practice. This is due to international criminal law’s foundational, legitimizing basis in natural law rather than political liberalism. I call for a revision of ICT institutional accountability structures.
Being Part of the “Home Team”
Authors: Collins Todd A. , Dumas Tao L. , Moyer Laura P. 
Published: February 2017

AbstractUnderstanding how attorneys’ perceptions of “insider” and “outsider” status affect negotiations is of both theoretical and practical importance for understanding the judicial system. We utilize a comprehensive survey of attorneys from one state to explore views of trustworthiness and negotiations. Overall, as attorneys become more embedded in their in-group, they increasingly report lower trust levels and less effective negotiations with outsiders. These relationships do vary somewhat by the scope and location of the attorney’s practice. Our findings provide insight into one possible causal mechanism underlying the “repeat player” advantage; they also suggest new directions for research on case outcomes.
Segmental Neurofibromatosis
Authors: Alexander Tiffany , Tran Bao Anh Patrick , Chen Wen , Maiberger Mary 
Published: February 2017

ABSTRACT
Segmental neurofibromatosis is a rare condition that most commonly affects women and presents as neurofibromas, café au lait spots, and freckling. The neurofibromas usually occur in a dermatomal pattern, whereas the café au lait spots may follow Blaschko’s lines. There is often no family history. The etiology is due to a postzygotic mutation in the gene encoding neurofibromin. Histopathology reveals a tumor with haphazardly arranged spindle cells and a pale myxoid stroma from mucin deposition and fibroplasia. There have been few reported cases of segmental neurofibromatosis. In this case report, we will discuss the clinical features, histopathology, differential diagnosis, and management of segmental neurofibromatosis.
Covered Balloon-Expanding Stents in Airway Stenosis
Authors: Majid Adnan , Kheir Fayez , Chung Jey , Alape Daniel , Husta Bryan , Oh Scott , Folch Erik 
Published: February 2017

Background:
The balloon-expanding stents are widely available but rarely described for use within the tracheobronchial tree. This report describes our experience with these stents in airway stenosis particularly as a lobar salvage therapy.

Methods:
This was a retrospective review of all records in which the balloon-expanding stents were used at a tertiary medical center. Ages, sex, location of stenosis, etiology of stenosis, stent size, duration of stent placement and associated interventions for airway stenosis were recorded. Patient’s self-reported respiratory symptoms, dyspnea scale, and radiographic imaging at baseline and after stent placement were also reported.

Results:
Twenty-one Atrium iCAST stents were inserted in 18 patients with malignant and benign airway disease. The median age was 69.5 years (interquartile range, 53.5 to 74). Most stents (n=20, 95%) were deployed in the lobar airways. There was a significant improvement in the modified Medical Research Council dyspnea scale from median of 3 to 2 (P<0.05). Self-reported respiratory symptoms improved in 14 patients (78%, P<0.05). Radiographic improvement post Atrium iCAST stent placement was achieved in 15 patients (83%). No deaths were related to airway stenting complications. Adverse events related to stents included migration (n=2, 9.5%), granulation tissue formation (n=2, 9.5%) and mucus plugging (n=1, 4.8%).

Conclusions:
Lobar stenting with balloon-expanding metallic stents appears feasible, safe and improves symptoms as well as radiographic atelectasis in patients with lobar airway stenosis in this small case series. Larger studies are needed to confirm this observation and to address long-term safety.
Hardwiring Bedside Shift Report
Authors: Scheidenhelm Sandra , Reitz O. Ed 
Published: February 2017

OBJECTIVE
The purpose of this project was to increase nurse compliance with bedside report and increase patient satisfaction scores.

BACKGROUND
Bedside report is an evidence-based practice used to increase patient involvement in their care and improve patient satisfaction. A change management strategy and standardized approach to bedside report can help increase nurse compliance with the process.

METHODS
This study used a quasi-experimental, between-group, preimplementation and postimplementation comparison of patient satisfaction scores from returned surveys on 2 units in a 149-bed community hospital. We also compared nurse compliance with bedside report preimplementation and postimplementation.

RESULTS
Five months after using a change management strategy to “hardwire” (ingrain systems and tools) bedside report, nurse compliance with bedside report and patient satisfaction scores improved in both intervention units.

CONCLUSIONS
A change management strategy and standardized approach to bedside report helped increase nurse compliance with the process, leading to improved patient satisfaction.
MEACA: efficient gene-set interpretation of expression data using mixed models
Authors: Zhuo Bin , Jiang Duo 
Published: February 2017

AbstractCompetitive gene-set analysis, or enrichment analysis, is widely used for functional interpretation of gene expression data. It tests a known category (e.g. pathway) of genes for enriched differential expression signals. Current methods do not properly capture inter-gene correlations and heterogeneity, resulting in mis-calibration and power loss. We propose MEACA, a new gene-set method based on mixed-effects models. MEACA flexibly incorporates unknown heterogeneity and correlations across genes, and does not need time-consuming permutations. Compared to existing methods, MEACA substantially improves type 1 error control and power in widely ranging scenarios. Real data applications demonstrate MEACA’s ability to recover biologically meaningful relationships.
Collective effects of common SNPs and improved risk prediction in lung cancer
Authors: Lei Xiaoyun , Yuan Dejian , Zhu Zuobin , Huang Shi 
Published: February 2017

AbstractLung cancer is the leading cause of cancer deaths in both men and women in the US. While most sporadic lung cancer cases are related to environmental factors such as smoking, genetic susceptibility may also play an important role and a number of lung cancer associated single nucleotide polymorphisms (SNPs) have been identified although many remain to be found. The collective effects of genome wide minor alleles of common SNPs, or the minor allele content (MAC) in an individual, have been linked with quantitative variations of complex traits and diseases. Here we studied MAC in lung cancer using previously published SNP datasets and found higher MAC in cases relative to matched controls. A set of 25883 SNPs with MA (MAF < 0.5) more common in cases (P< 0.1) was found to have the best predictive accuracy. A weighted risk score calculated by using this set can predict 2.6% of lung cancer cases (100% specificity). These results identify a novel genetic risk element or higher MAC in lung cancer susceptibility and provide a useful genetic method to identify a small fraction of lung cancer cases.
Genes Affecting Vocal and Facial Anatomy Went Through Extensive Regulatory Divergence in Modern Humans
Authors: Gokhman David , Nissim-Rafinia Malka , Agranat-Tamir Lily , Housman Genevieve , García-Pérez Raquel , Lizano Esther , Cheronet Olivia , Mallick Swapan , Nieves-Colón Maria A. , Li Heng , Alpaslan-Roodenberg Songül , Novak Mario , Gu Hongcang , Osinski Jason M. , Ferrando-Bernal Manuel , Gelabert Pere , Lipende Iddi , Mjungu Deus , Kondova Ivanela , Bontrop Ronald , Kullmer Ottmar , Weber Gerhard , Shahar Tal , Dvir-Ginzberg Mona , Faerman Marina , Quillen Ellen E. , Meissner Alexander , Lahav Yonatan , Kandel Leonid , Liebergall Meir , Prada María E. , Vidal Julio M. , Gronostajski Richard M. , Stone Anne C. , Yakir Benjamin , Lalueza-Fox Carles , Pinhasi Ron , Reich David , Marques-Bonet Tomas , Meshorer Eran , Carmel Liran 
Published: February 2017

SummaryRegulatory changes are broadly accepted as key drivers of phenotypic divergence. However, identifying regulatory changes that underlie human-specific traits has proven very challenging. Here, we use 63 DNA methylation maps of ancient and present-day humans, as well as of six chimpanzees, to detect differentially methylated regions that emerged in modern humans after the split from Neanderthals and Denisovans. We show that genes affecting the face and vocal tract went through particularly extensive methylation changes. Specifically, we identify widespread hypermethylation in a network of face- and voice-affecting genes (SOX9,ACAN,COL2A1,NFIXandXYLT1). We propose that these repression patterns appeared after the split from Neanderthals and Denisovans, and that they might have played a key role in shaping the modern human face and vocal tract.
Cigarette smoking increases coffee consumption: findings from a Mendelian randomisation analysis
Authors: Bjørngaard Johan H , Nordestgaard Ask Tybjærg , Taylor Amy E , Treur Jorien L , Gabrielsen Maiken E. , Munafò Marcus R , Nordestgaard Børge Grønne , Åsvold Bjørn Olav , Romundstad Pål , Smith George Davey 
Published: February 2017

AbstractBackgroundSmokers tend to consume more coffee than non-smokers and there is evidence for a positive relationship between cigarette and coffee consumption in smokers. Cigarette smoke increases the metabolism of caffeine, so this association may represent a causal effect of smoking on caffeine intake.MethodsWe performed a Mendelian randomisation analysis in 114,029 individuals from the UK Biobank, 56,664 from the Norwegian HUNT study and 78,650 from the Copenhagen General Population Study. We used a genetic variant in theCHRNA5nicotinic receptor (rs16969968) as a proxy for smoking heaviness. Coffee and tea consumption were self-reported. Analyses were conducted using linear regression and meta-analysed across studies.ResultsEach additional cigarette per day consumed by current smokers was associated with higher coffee consumption (0.10 cups per day, 95% CI:0.03,0.17). There was weak evidence for an increase in tea consumption per additional cigarette smoked per day (0.04 cups per day, 95% CI:-0.002,0.07). There was strong evidence that each additional copy of the minor allele of rs16969968 (which increases daily cigarette consumption) in current smokers was associated with higher coffee consumption (0.15 cups per day, 95% CI:0.11,0.20), but only weak evidence for an association with tea consumption (0.04 cups per day, 95% CI:- 0.01,0.09). There was no clear evidence that rs16969968 was associated with coffee or tea consumption in never or former smokers.ConclusionThese findings suggest that higher cigarette consumption causally increases coffee intake. This is consistent with faster metabolism of caffeine by smokers, but may also reflect behavioural links between smoking and coffee.