bluuebunny/crossref_metadata_2025_split huggingface dataset:
The longitudinal effects of emotion regulation on physical and psychological health: A latent growth analysis exploring the role of cognitive fusion in inflammatory bowel disease
Authors: Trindade Inês A. , Ferreira Cláudia , Pinto‐Gouveia José 
Published: October 2017

ObjectiveThis study thus aims to test differences between patients with inflammatory bowel disease (IBD) regarding IBD symptomatology, cognitive fusion, and psychological and physical health, as well as to explore whether the maladaptive emotion regulation process of cognitive fusion longitudinally impacts on the baseline and evolution of these outcomes over a period of 18 months.Design and methodsParticipants include 116 IBD patients with a mean age of 36.76 (SD = 11.39) of both genders (69.83% females) that completed the self‐report measures of interest in three different times, equally spaced 9 months apart, over a period of 18 months. Latent growth curve models were conducted using structural equation modelling to estimate the growth trajectory of the variables in study.ResultsInflammatory bowel disease symptomatology and cognitive fusion's levels were negatively associated with psychological health and physical health's baseline levels. Furthermore, IBD symptomatology did not influence the growth of psychological health, while cognitive fusion did (β = .30, p = .007). The same result was found for physical health (β = .26, p = .024). These findings indicate that individuals with higher levels of cognitive fusion present lower levels of psychological health and physical health that tend to further decrease over the time through the effects of this maladaptive emotion regulation process.ConclusionsThis study implies that it is of crucial importance to include psychotherapeutic interventions in the health care of patients with IBD. If successful, these interventions could represent decreases in the cost of IBD treatment and in the use of drugs with adverse side effects, in addition to improving patients’ mental health and quality of life. Further implications for clinical and research work are discussed.
Statement of contribution

What is already known on this subject?

Research has demonstrated the impact of emotion regulation on both physical and mental health.

Nevertheless, the longitudinal effects of the specific emotion regulation process of cognitive fusion on physical and psychological health have never been explored.

Additionally, no study has yet examined the causal role of emotion regulation in evolution of physical health in inflammatory bowel disease (IBD).

What does this study add?

Cognitive fusion longitudinally impacted on IBD patients’ physical and mental health.

These variables were measured over a period of 18 months.

Treatment for IBD should include interventions aiming to diminish maladaptive emotion regulation.
Neural stem cells and adult brain fatty acid metabolism: Lessons from the 3xTg model of Alzheimer's disease
Authors: Hamilton Laura K. , Fernandes Karl J. L. 
Published: October 2017

AbstractNeural stem cell (NSC) activity and adult neurogenesis are physiologically relevant regulators of adult brain structure, function and repair. Given these roles, the NSC impairments observed in a wide range of neurodegenerative and psychiatric conditions likely factor into the overall cognitive dysfunction in these conditions. We investigated NSC regulation in the context of Alzheimer's disease (AD) using the well‐characterised triple transgenic (3xTg) model of AD. In this review, we describe our recent findings that link 3xTg‐AD neurogenesis impairments to AD‐associated abnormalities in brain fatty acid metabolism. Notably, we identified an accumulation of triglycerides rich in oleic acid, a mono‐unsaturated fatty acid, within the forebrain NSC niche in AD. Inhibiting the local conversion of saturated to mono‐unsaturated fatty acids within the brain was sufficient to counteract the loss of NSC activity in 3xTg‐AD mice (Hamilton et al., 2015). We place these findings within the context of recent evidence that dynamic changes in lipid metabolism occur during the transition from NSC quiescence to activation. The picture that emerges is that the critical NSC quiescence‐to‐activation decision is sensitive to the local levels of specific fatty acids and can be impaired by a disease‐associated shift in brain fatty acid balance.
Incidence and risk factors for parastomal bulging in patients with ileostomy or colostomy: a register‐based study using data from the Danish Stoma Database Capital Region
Authors: Andersen R. M. , Klausen T. W. , Danielsen A. K. , Vinther A. , Gögenur I. , Thomsen T. 
Published: October 2017

AbstractAimThe aim was to investigate the incidence and risk factors for parastomal bulging, a clinically important complication, in patients with an ileostomy or colostomy.MethodThe Danish Stoma Database Capital Region prospectively collects data on patients with a stoma up to a year after surgery. Stoma care nurses clinically assessed the main outcome, parastomal bulging. We linked data from the Stoma Database to data from the Danish Anaesthesia Database. Cumulative incidence of parastomal bulging over the first year was calculated with death and stoma reversal as competing risks. Risk factors were investigated using an exploratory approach.ResultsIn a study population of 5019, the cumulative incidence (with competing risks) of parastomal bulging was 36.2% at 400 days after surgery. Age, colostomy, male gender, alcohol consumption and laparoscopy were associated with an increased risk of parastomal bulging. Compared with cancer, inflammatory bowel disease was associated with a lower risk of parastomal bulging, and diverticulitis was associated with a higher risk. Peristomal mesh and stomas placed through a separate incision were associated with a reduction in risk. There was neither increased nor decreased risk of parastomal bulging for body mass index, American Society of Anesthesiologists score, smoking status, emergency surgery and preoperative stoma site marking.ConclusionParastomal bulging is a common complication affecting one in three patients within 1 year of surgery. Along with previous findings, there is now considerable evidence for age and colostomy as being risk factors for parastomal bulging.
Incidence of venous thromboembolic events in enhanced recovery after surgery for colon cancer: a retrospective, population‐based cohort study
Authors: Vendler M. M. I. , Haidari T. A. , Waage J. E. , Kleif J. , Kristensen B. , Gögenur I. , Bertelsen C. A. ,   the Copenhagen cOmplete Mesocolic Excision Study group (COMES)
Published: October 2017

AbstractAimBoth the Danish and the National Institute of Clinical Excellence (NICE) guidelines recommend prolonged thromboprophylaxis (PT) with low‐molecular‐weight heparin (LMWH) for 28 days postoperatively after elective surgery for colon cancer. The evidence relies on data from two randomized clinical trials (RCTs) that included not only colon cancers but also other abdominal cancers or benign colorectal diseases. Neither of those studies investigated the risk of venous thromboembolism (VTE) under enhanced recovery after surgery (ERAS). We aim to describe the risk of VTE and estimate the cost of preventing one case of VTE by PT under ERAS.MethodThis was a retrospective study of 2230 patients undergoing elective surgery for colon cancer Stage I‐III in the Capital Region of Denmark, 1 June 2008 to 31 December 2013. Patients who were discharged on postoperative day 28 or later, died during admission or were discharged with a vitamin K antagonist, novel oral anticoagulants or LMWH were excluded. Patients with rectal cancer only were not included. End‐points were symptomatic VTE diagnosed within 60 days postoperatively.ResultsThree‐hundred and thirty patients were excluded. For the remaining 1893, the median length of stay (LOS) was 4 [interquartile range (IQR): 3–5] days. Of these 1893 patients, four (0.20%) experienced a nonfatal symptomatic VTE. All four patients had other postoperative complications before the VTE. The cost of each symptomatic VTE prevented is estimated to be between £63 709 and £111 455 when medication and home‐care nursing are included.ConclusionThe risk of symptomatic VTE after uncomplicated, elective surgery for colon cancer with ERAS seems negligible and the cost‐effectiveness of PT to prevent one symptomatic VTE seems questionable.
Defektdeckung am Nasenflügel durch die kaudolateral gedrehte Transpositionslappenplastik und ihre Varianten
Authors: Felcht Moritz 
Published: October 2017

ZusammenfassungDefekte am Nasenflügel können für den Dermatochirurgen eine Herausforderung darstellen. Unterschiedliche Methoden der Defektdeckung wurden in der Vergangenheit entwickelt, allerdings sind diese teilweise kompliziert zu erlernen und durchzuführen. Der Dermatochirurg Andreas Lösler aus der Fachklinik für Dermatologie Hornheide, hat kürzlich die kaudolateral gedrehte Transpositionslappenplastik zur Deckung von Defekten am Nasenflügel entwickelt und publiziert. Diese zeigt eine sehr geringe Komplikationsrate. Da sie noch relativ neu ist, ist diese Technik den meisten Dermatochirurgen noch nicht bekannt und bisher auch nicht in den Standardwerken der Dermatochirurgie erwähnt. In dieser Übersichtsarbeit wird die Technik der kaudolateral gedrehten Transpositionslappenplastik beschrieben und zwei Varianten vorgestellt, die es erlauben, auch große Defekte und lateral gelegene Defekte im Bereich des Nasenflügels zu decken. Der kaudolateral gedrehte Transpositionslappen wird mit den beiden häufigsten Lappenplastiken zur Defektdeckung im Bereich des Nasenflügels, dem zweifach gestielten Lappen (bilobed flap) und der melolabialen Transpositionslappenplastik verglichen.
S1 guidelines for the diagnosis and treatment of ichthyoses – update
Authors: Oji Vinzenz , Preil Marie‐Luise , Kleinow Barbara , Wehr Geske , Fischer Judith , Hennies Hans Christian , Hausser Ingrid , Breitkreutz Dirk , Aufenvenne Karin , Stieler Karola , Tantcheva‐Poór Illiana , Weidinger Stefan , Emmert Steffen , Hamm Henning , Perusquia‐Ortiz Ana Maria , Zaraeva Irina , Diem Anja , Giehl Kathrin , Fölster‐Holst Regina , Kiekbusch Kirstin , Höger Peter , Ott Hagen , Traupe Heiko 
Published: October 2017

SummaryIchthyoses are a group of rare genetic skin disorders that pose numerous clinical challenges, in particular with respect to the correct diagnosis and appropriate management. The present update of the German ichthyosis guidelines addresses recent diagnostic advances that have resulted in the Sorèze consensus classification. In this context, we provide an updated diagnostic algorithm, taking into account clinical features as well as the molecular genetic basis of these disorders. Moreover, we highlight current therapeutic approaches such as psychosocial support, balneotherapy, mechanical scale removal, topical therapy, and systemic retinoid therapy. General aspects such as the indication for physical therapy, ergotherapy, or genetic counseling are also discussed. The present update was consented by an interdisciplinary consensus conference that included dermatologists, pediatricians, human geneticists, and natural scientists as well as representatives of the German patient support organization Selbsthilfe Ichthyose e. V.
Polypoidal choroidal vasculopathy treatment options: A meta‐analysis
Authors: Qian Tianwei , Li Xinxin , Zhao Mengya , Xu Xun 
Published: October 2017

AbstractBackgroundCombined treatment with intravitreal anti‐vascular endothelial growth factor (anti‐VEGF) and verteporfin photodynamic therapy (PDT) is widely used for patients with polypoidal choroidal vasculopathy (PCV), although clinical evidence regarding the therapeutic efficacy and safety of such treatment remains lacking.Design/MethodsWe performed a meta‐analysis of previously reported studies comparing combination treatment, PDT monotherapy, and anti‐VEGF monotherapy. Primary outcome measures included changes in best‐corrected visual acuity (BCVA) and central retinal thickness (CRT). The proportion of patients with polyp regression was regarded as the secondary outcome measure.ResultsTwenty studies (three RCTs and 19 retrospective studies) involving 1,178 patients with PCV were selected. Significant differences in the proportion of patients with polyps were observed between the PDT and anti‐VEGF monotherapy groups at 3 and ≥6 months (P < .00001; and P = .0001, respectively). Significantly greater reductions in CRT were observed in the anti‐VEGF than in the PDT group at the 3‐month follow‐up (P = .04). Significantly greater improvements in BCVA were observed in the combined therapy group than in the PDT monotherapy group at 3, 6, 12, and 24 months (P = .03; P = .005; P = .02; and P < .00001, respectively). Combined treatment also resulted in significantly greater improvements in BCVA than monotherapy with anti‐VEGF at 6 and 24 months (P = .001; P < .00001, respectively), and significantly greater polyp regression than that observed following anti‐VEGF treatment at 3 and ≥6 months (P < .00001; P < .0001, respectively).ConclusionsCombined therapy involving anti‐VEGF agents and PDT may be more effective in improving long‐term outcomes for patients with PCV than monotherapy.
Brain and heart magnetic resonance imaging/spectroscopy in duchenne muscular dystrophy
Authors: Mavrogeni Sophie , Pons Roser , Nikas Ioannis , Papadopoulos George , Verganelakis Dimitrios A. , Kolovou Genovefa , Chrousos George P. 
Published: October 2017

AbstractDuchenne muscular dystrophy (DMD) is an X‐linked muscle disorder characterized by progressive and irreversible loss of muscular function. As muscular disease progresses, the repair mechanisms cannot compensate for cellular damage, leading inevitably to necrosis and progressive replacement by fibrous and fatty tissue. Cardiomyopathy and respiratory failure are the main causes of death in DMD. In addition to the well‐described muscle and heart disease, cognitive dysfunction affects around 30% of DMD boys. Myocardial fibrosis, assessed by late gadolinium enhancement (LGE), using cardiovascular magnetic resonance imaging (CMR), is an early marker of heart involvement in both DMD patients and female carriers. In parallel, brain MRI identifies smaller total brain volume, smaller grey matter volume, lower white matter fractional anisotropy and higher white matter radial diffusivity in DMD patients. The in vivo brain evaluation of mdx mice, a surrogate animal model of DMD, showed an increased inorganic phosphate (P(i))/phosphocreatine (PCr) and pH. In this paper, we propose a holistic approach using techniques of magnetic resonance imaging, spectroscopy and diffusion tensor imaging as a tool to create a “heart and brain imaging map” in DMD patients that could potentially facilitate the patients’ risk stratification and also future research studies in the field.
Foreign direct investment and inequality in developing countries: Does sector matter?
Authors: Bogliaccini Juan A. , Egan Patrick J. W. 
Published: October 2017

AbstractScholars have studied the relationship between inward foreign direct investment (FDI) and within‐country income inequality in cross‐national contexts, but have not empirically investigated how FDI in different sectors might affect inequality in different ways. We use error correction models to analyze sectoral FDI data compiled from UNCTAD investment reports in 60 middle‐income countries from 1989 to 2010, arguing that FDI in services is more likely to be associated with inequality than FDI in other sectors. We argue that skill biases and changes in employment patterns associated with service sector investments can help explain these findings.
Between discretion and control: Reflections on the institutional position of the Commission within the European citizens' initiative process
Authors: Vogiatzis Nikos 
Published: October 2017

AbstractThis article considers the institutional position of the Commission within the European citizens' initiative (ECI) process, with particular emphasis on its decision regarding the admissibility/registration of a proposed ECI, and its final decision on the outcome of an ECI which has met the necessary levels of support. The purpose of this contribution is to juxtapose the case‐law of the Court on the Commission's discretion and the relevant provisions of the Treaties with the evolution of European integration and, more specifically, the evolution of the Commission's role therein. Viewed under this prism, the Commission's powers at the registration stage (which in any event clearly fall under the scope of judicial review) are compatible with the constitutionalisation of the Union, whereas the Commission's width of discretion at the follow‐up stage, while compatible with the Commission's prerogatives, cannot easily be reconciled, nonetheless, with the Commission's limited legitimacy when compared to that of the co‐legislators, the fact that it may not always represent the Union interest, and the latter's pragmatic losses within the EU institutional balance.
Prediction of fracture loads in PMMA U‐notched specimens using the equivalent material concept and the theory of critical distances combined criterion
Authors: Cicero S. , Torabi A.R. , Madrazo V. , Azizi P. 
Published: October 2017

AbstractThis paper provides a methodology for the prediction of fracture loads in notched materials that combines the equivalent material concept with the theory of critical distances. The latter has a linear‐elastic nature and requires material calibration in those cases where the non‐linear material behaviour is significant. The calibration may be performed by fracture testing on notched specimens or a combination of fracture testing and simulation. The proposed methodology sets out to define an equivalent linear‐elastic material on which the theory of critical distances may be applied through its basic formulation and without any previous fracture testing and/or simulation. It has been applied to PMMA single edge notch bending specimens containing U‐notches, providing accurate predictions of fracture loads.
A novel approach for modeling retained austenite transformations during rolling contact fatigue
Authors: Morris D. , Sadeghi F. , Chen Y.‐C. , Wang C. , Wang B. 
Published: October 2017

AbstractRetained austenite (RA) transformation in martensitic steels subjected to rolling contact fatigue (RCF) is a well‐established phenomenon. In this investigation, a novel approach is developed to predict martensitic transformations of RA in steels subjected to RCF. In order to achieve the objectives, a 2‐dimensional finite element model was developed to determine subsurface stresses due to rolling contact. These stresses are utilized within a continuum damage mechanics framework to determine RA transformations as a function of depth and cycles. Phase transformations were determined by comparing the required thermodynamic driving force for transformations to the energy dissipation of the microstructure. The results obtained from the combined FEA and continuum damage mechanics model were corroborated to the experimental results for RA decomposition as a function of depth and cycle for SAE 52100 steel. The results obtained are in good agreement with observed RA decomposition and DER formation as compared with the experimental results.
Occipital Nerve Stimulation for Medically Refractory Chronic Paroxysmal Hemicrania
Authors: Miller Sarah , Lagrata Susie , Watkins Laurence , Matharu Manjit 
Published: October 2017

ObjectiveTo describe the outcome of a patient with refractory chronic paroxysmal hemicrania (CPH) to occipital nerve stimulation (ONS).BackgroundCPH is a primary headache disorder exquisitely sensitive to indomethacin. In patients unable to tolerate indomethacin, the therapeutic options are limited. ONS is a promising therapy for other refractory headache conditions. We report the first patient with medically refractory CPH treated with ONS.MethodsFollowing implantation of the occipital nerve stimulator in 2006, the patient kept prospective headache diaries. Outcome was assessed by daily attack frequency.ResultsAfter a follow‐up of over 10 years, the patient reported a sustained efficacy of more than 50% reduction in attack frequency and was pain‐free at final follow‐up. The patient was able to stop indomethacin completely. The patient had three successful pregnancies during follow‐up. One system revision was undertaken alongside an expected battery replacement to treat unequal paresthesia and pain over the electrodes.ConclusionONS may offer an effective long‐term treatment for CPH in patients where indomethacin cannot be tolerated.
Comparison of performance and abnormal cell flagging of two automated hematology analyzers: Sysmex XN 3000 and Beckman Coulter DxH 800
Authors: Genc S. , Dervisoglu E. , Erdem S. , Arslan O. , Aktan M. , Omer B. 
Published: October 2017

AbstractIntroductionThe purpose was to evaluate the analytical performances of Sysmex XN 3000 and UniCel DxH 800 comparing the obtained results with manual counting and between each other. Also flagging capabilities of abnormal cells were compared for both analyzers.MethodsTwo thousand one hundred and forty‐two whole‐blood samples were analyzed for evaluation. The samples flagged due to blast, atypical lymphocyte (AL), immature granulocyte (IG), or nucleated red blood cells (NRBC) were microscopically reviewed (n=102).ResultsThe within‐run and between‐day coefficient of variations (CV%) of XN 3000 for hemoglobin, RBC, MCV, WBC, and platelets were lower than 5% and for WBC differentials lower than 10% except monocytes which was 15.6% at low level. The precision results of DxH 800 were also lower than 5.0% except platelets (9.5%) and monocytes (45%) at low level. The comparison of analyzers revealed good agreement (R>.86), except monocytes and basophils. The flagging sensitivities of XN 3000 were higher for IGs, blasts, and ALs than those of DxH 800 and almost similar for NRBC.ConclusionThe XN 3000 and DxH 800 are accurate, highly precise systems and can be used effectively in high‐volume laboratories. The flagging sensitivity of XN 3000 was higher in detecting blasts, IGs, and ALs than that of DxH 800. The detection of abnormal cells with high sensitivity may improve laboratory workflow with a reduced slide review and accelerated turnaround time.
Impact of four direct oral anticoagulants on rotational thromboelastometry (ROTEM)
Authors: Seyve L. , Richarme C. , Polack B. , Marlu R. 
Published: October 2017

AbstractIntroductionRotational Thromboelastometry (ROTEM) is a point of care method used to monitor coagulation during surgery and to guide transfusion strategies in patients presenting with severe bleeding. The aim of our study was to determine the impact of four direct oral anticoagulants (DOACs) on 3 commonly used ROTEM tests.MethodsWhole blood samples from 20 healthy donors were spiked in vitro with apixaban, edoxaban, rivaroxaban or dabigatran at 5 different plasma concentrations (0‐1000 ng/mL). EXTEM, INTEM and FIBTEM tests were systematically performed.ResultsThere was a linear relationship between the increase in clotting time (CT) and plasma DOAC concentrations in both the EXTEM and INTEM tests. We found that the DOAC concentration required to double EXTEM CT was 1042 ± 225 ng/mL for apixaban, 134 ± 38 ng/mL for edoxaban, 176 ± 26 ng/mL for rivaroxaban and 284 ± 73 ng/mL for dabigatran. INTEM CT was less sensitive than EXTEM CT whatever the anticoagulant. EXTEM CT was above the normal range for 5 of 5 spiked samples when the plasma concentrations were ~1000 ng/mL for apixaban, ~100 ng/mL for edoxaban, ~200 ng/mL for rivaroxaban and ~200 ng/mL for dabigatran. Maximum Clot Firmness in EXTEM, INTEM and FIBTEM tests was not affected whatever the DOAC or its concentration.ConclusionThis study found a DOAC dose‐dependent increase in ROTEM CTs. ROTEM tests were only poorly impacted by low levels of edoxaban, rivaroxaban or dabigatran. Apixaban had only a low effect even at high concentrations.