bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low plasma FVII:C and activated FVII as predictive markers for overt disseminated intravascular coagulation
Authors: Lertthammakiat Surapong , Anantasit Nattachai , Anurathapan Usanarat , Sirachainan Nongnuch , Kadegasem Praguywan , Chuansumrit Ampaiwan 
Published: May 2017

SummaryIn sepsis, binding of factor VII (FVII:C) and activated factor VII (FVIIa) with tissue factor is the key step of coagulation resulting in disseminated intravascular coagulation (DIC). We conducted a prospective cohort study among 47 septic patients, aged 8 months to 18.8 years. They were initially divided into three groups of no DIC (n=27), non-overt DIC (n=14) and overt DIC (n=6). Blood samples were collected at 0, 24 and 48 hours (h) after the onset of sepsis. At the onset of sepsis, FVII:C tended to be lower in the non-overt DIC [median 57% (interquartile range [IQR] 41–80)] and overt DIC groups [33% (23–52)] than that in the no DIC group [65% (44–87)]. Whereas FVIIa tended to be lower in the overt DIC group [1.29% (0.50–4.19)] than those in the non-overt DIC [3.01% (1.01–5.24)] and no DIC groups [2.49% (1.14–3.13)]. At 24 h, FVII:C was significantly lower in the non-overt DIC [57% (41–101)] and overt DIC groups [31% (28–49)] than that in the no DIC group [83% (70–102)]. While FVIIa was significantly lower in the overt DIC group [2.15% (0.86–3.96)] than that in the no DIC group [3.83% (2.90–5.46)]. Using FVII:C <65% or FVIIa <3% at 24 h among patients without hepatic dysfunction to determine overt DIC at 24 h, the sensitivity was 83.9% and 77.4%, respectively, and the specificity was both 83.3%. Patients with low FVII:C and low FVIIa at 24 h after the onset of sepsis had a 20.8-fold (95% confidence interval [CI], 2.0–213.0, p=0.010) and 14.4-fold (95%CI, 1.5–142.4, p=0.023) chance of overt DIC.
Complex recombination with deletion in the F8 and duplication in the TMLHE mediated by int22h copies during early embryogenesis
Authors: Chen Changming , Xie Xiaoling , Wu Xi , Lu Yeling , Wang Xuefeng , Wu Wenman , Hu Yiqun , Ding Qiulan 
Published: May 2017

SummaryHaemophilia A (HA) is a common X-linked recessive bleeding disorder and almost one half of patients with severe HA are caused by intron 22 inversion (Inv22) in the F8. Inv22 is considered to be almost exclusively of meiotic origin in germ cells during spermatogenesis and only one mosaic Inv22 female carrier with the mutation possibly occurring during mitosis of the embryo has been reported so far. Previously we have identified a novel complex recombination mediated by int22h copies in a sporadic severe HA pedigree and herein we have localised the sequences flanking the breakpoint region using genome walking technique, AccuCopy technique, gene chip and real-time PCR. The disease causing genetic variant registered an 18.1 kb deletion including part of int22h-1 through the intron 23 of F8 and a 113.3 kb duplication of part of int22h-2 through the intron 1 of TMLHE inserted in the religated region of the F8. Two intrinsically linked mechanisms of recombination-dependent DNA replication: microhomology-mediated break-induced replication (MMBIR) followed by break-induced replication (BIR) might be responsible for the incident of the complex recombination during early embryogenesis of the proband’s mother.Supplementary Material to this article is available online at www.thrombosis-online.com.
Buildings, Beauty, and the Brain: A Neuroscience of Architectural Experience
Authors: Coburn Alex , Vartanian Oshin , Chatterjee Anjan 
Published: May 2017

AbstractA burgeoning interest in the intersection of neuroscience and architecture promises to offer biologically inspired insights into the design of spaces. The goal of such interdisciplinary approaches to architecture is to motivate construction of environments that would contribute to peoples' flourishing in behavior, health, and well-being. We suggest that this nascent field of neuroarchitecture is at a pivotal point in which neuroscience and architecture are poised to extend to a neuroscience of architecture. In such a research program, architectural experiences themselves are the target of neuroscientific inquiry. Here, we draw lessons from recent developments in neuroaesthetics to suggest how neuroarchitecture might mature into an experimental science. We review the extant literature and offer an initial framework from which to contextualize such research. Finally, we outline theoretical and technical challenges that lie ahead.
Traffic analysis of a three-dimensional elevator system
Authors: So Albert , Al-Sharif Lutfi , Hammoudeh Ahmad 
Published: May 2017

This article presents an overview of the concept of a hypothetical three-dimensional elevator system in extra-large buildings. The term three dimensional is used in this context in order to contrast the system with current conventional one-dimensional elevator systems that move bi-directionally in a dedicated vertical shaft; or two-dimensional elevator system that moves in a plane (e.g. in x-horizontal direction and z-vertical direction). The hypothetical three-dimensional elevator system presented in this article assumes that the elevator car can travel in all three directions (but obviously not at the same time). The proposed system comprises a vertical main shaft that allows elevator cars to travel to the required floor, and then to travel in two dimensions in a horizontal plane at the level of the required floor along a network of horizontal shafts in both x- and y- directions. Each elevator car is dispatched to one floor only in each round trip. This is more efficient as it removes the need to visit more than one floor in each journey, but relies heavily on the use of destination group control systems (in order to allow the allocation of the passengers destined to the same floor to the same elevator car). The article presents the general overview of the suggested system using sketches and then derives equations for calculating the round trip time for the elevator car. The Monte Carlo Simulation method is then used to verify the correctness of the derived equations. Practical application: This manuscript provides a high level overview of the possible arrangement of a three-dimensional elevator traffic systems in a very large building. It can be used by architects to explore the possibility of employing a three-dimensional elevator system in a large building and checking its feasibility.
Deployment-Related Traumatic Events and Suicidal Behaviours in a Nationally Representative Sample of Canadian Armed Forces Personnel
Authors: Sareen Jitender , Afifi Tracie O. , Taillieu Tamara , Cheung Kristene , Turner Sarah , Stein Murray B. , Zamorski Mark A. 
Published: May 2017

Objective: Worldwide, there has been substantial controversy with respect to whether military deployment is a risk factor for suicidal behaviour. The present study examined the relationship between lifetime exposure to deployment and deployment-related traumatic events (DRTEs) and past-year suicidal ideation (SI), suicidal plans (SP), and suicidal attempts (SA). Method: Data were analysed from the 2013 Canadian Forces Mental Health Survey (8161 respondents; response rate, 79.8%; aged 18-60 years). A total of 12 individual items assessed exposure to DRTEs (e.g., combat, witnessing human atrocities, feeling responsible for the death of Canadian or ally personnel, knowing someone who was injured or killed). We examined each individual DRTE type as well as the number of types of DRTEs in relation to suicidal behaviour. Results: Lifetime deployment was not significantly associated with suicidal behaviour. In models adjusted for sociodemographic variables, most of the individual DRTE items and the DRTE count variable were significantly associated with suicidal behaviours (adjusted odds ratio ranged between 1.10 and 5.32). When further adjusting for child abuse exposure, these associations were minimally attenuated, and some became nonsignificant. In models adjusting for mental disorders and child abuse, most DRTEs and number of types of DRTEs became nonsignificant in relation to SI, SP, and SA. Conclusions: Active military personnel exposed to increasing number of DRTEs are at increased risk for SI, SP, and SA. However, most of the association between DRTEs and suicidal behaviour is accounted for by child abuse exposure and mental disorders.
Psychodynamic Aspects of Reserpine: Its Uses and Effects in Open Psychiatric Settings
Authors: Sarwer-Foner G. J. , Ogle W. 
Published: May 2017

1) Reserpine is a remarkable and useful drug. It has a definite place in psychiatry for the alleviation of selected symptoms. It is not in any sense a psychic “specific”. 2) The physiologic effects of this drug are relatively constant. The principal ones are a fall in blood pressure, a relative bradycardia, and in adequate dosage, a slowing of the patient's spontaneous activity; feelings of weakness, tiredness and of being held down. 3) There are other effects, which are predominantly psychological and it is felt that they have nothing to do with the physiological effects per se. They are the result of the way in which the physiological action fits into the patient's way of handling and expressing his conflict (i.e. defenses). When a patient does badly it is due to the way in which the physiological effects psychologically threaten the patient. A patient does well or badly depending on this, and we have seen enhanced anxiety as well as psychoses produced by both reserpine and chlorpromazine (8). 4) Because of the above, psychotherapeutic efforts are of the greatest importance, and when used, usually overshadow the effects of the drug. We feel that no patient is treated in a vacuum. Milieu and relationship is what counts most. The other factors, though important, are adjuvants. 5) A level of 10 to 40 mg./day will control most motor over-activity. Anxiety and most panics can be handled at between 2 and 10 mg./day. The average daily dose was 7 mg./day. The average length of treatment was 26 days. 6) Side effects are frequent, but are rapidly reversible. There were no serious or irreversible toxic effects. The drug is remarkably safe. 7) Reserpine is of about the same usefulness as chlorpromazine in psychiatry. Chlorpromazine is quicker acting. Reserpine is safer. When the G.I. tract is irritated or the site of symptoms, chlorpromazine is preferable. Cardiac or cardiovascular symptomatology might indicate a preference for reserpine, especially when bradycardia is desirable. Neither is a “specific” curative agent. Both are useful for the symptomatic relief of selected symptoms. Both have their contra indications. Neither is an effective substitute for intimate human contact with the patient. Both should be used along with psychotherapy.
Changes in blood pressure among patients in the Ontario Telehomecare programme: An observational longitudinal cohort study
Authors: Sahakyan Yeva , Abrahamyan Lusine , Shahid Nida , Stanimirovic Alexandra , Pechlivanoglou Petros , Mitsakakis Nicholas , Ryan Welson , Krahn Murray , Rac Valeria E 
Published: May 2017

Background The objective of this study was to investigate the changes in blood pressure among patients enrolled in the Telehomecare programme in Ontario, Canada. Methods This observational study utilised a prospective longitudinal cohort design, including patients with heart failure and chronic obstructive pulmonary disease enrolled in the Ontario Telehomecare programme from July 2012 to July 2015. The outcome of interest was change in mean (biweekly) systolic and diastolic blood pressure levels over a six-month period. Patient data were extracted from the Ontario Telemedicine Network database, and analysed using generalised linear mixed model procedures. Results Overall, we analysed data for 3513 patients. Patients were on average 74.1 ± 11.4 years of age; almost half were men, 62% had heart failure, 55% chronic obstructive pulmonary disease and 29% diabetes. At baseline, the mean systolic and diastolic blood pressure levels were 130.4 ± 19.1 mmHg and 72.2 ± 12.5 mmHg for the total sample. At six months, the adjusted reduction in systolic and diastolic blood pressure values were 4.0 mmHg (95% confidence interval: −4.5 to −3.5) and 2.7 mmHg (95% confidence interval: −3.1 to −2.4), respectively. In a subgroup of 1220 patients with uncontrolled blood pressure at baseline (systolic/diastolic blood pressure of 150.7 ± 10.2 mmHg/80.2 ± 13.5 mmHg) the adjusted reduction in systolic blood pressure was 12.5 mmHg (95% confidence interval: −13.4 to −11.6) and in diastolic blood pressure was 7.1 mmHg (95% confidence interval: −7.8 to −6.5) over the six-month period. Conclusions Blood pressure levels were significantly reduced in patients enrolled in the Telehomecare programme, with changes being more pronounced in patients with uncontrolled blood pressure. The sustainability of decreased blood pressure on other clinical outcomes needs further evaluation.
Wildlife corridors in india
Authors: Srivastava Raghav , Tyagi Richa 
Published: May 2017

Wildlife corridors, used by various species to migrate, breed and feed, are increasingly becoming relevant as essential tools for wildlife conservation. Rapid increase in industrial and infrastructural development, especially around forests, has resulted in widespread habitat fragmentation and isolation. Added to this, the growing development (for tourism, linear infrastructure etc.) around protected areas, and the altered de facto boundaries of these, have exacerbated this need. There is, however, no ‘hard’ statutory recognition afforded in India to wildlife corridors in spite of their established relevance in ecological conservation. Nor is there a strict prohibition on development within, and around important corridors in India. Even so, wildlife corridors have found passing mention in certain conservation law and guidelines framed thereunder, which seek to protect wildlife habitat and reduce human – wildlife conflict. These extant legal spaces have largely proved ineffective in the protection and conservation of corridors, and corridor protection and management continues to be a dormant legal space in India. This paper seeks to analyse the various barriers to corridor conservation and management, and whether the existing legal measures are underutilised in providing legal protection to wildlife corridors, without the need of a parallel institutional framework. Through an understanding of the criticality of corridors to wildlife conservation, the adequacy of existing legal structures has been examined by the authors, and recommendations made for augmenting the current legal framework with more concrete strategies.
Childhood maltreatment and inflammation among pregnant women with gestational diabetes mellitus: A pilot study
Authors: Bublitz Margaret , De La Monte Suzanne , Martin Susan , Larson Lucia , Bourjeily Ghada 
Published: May 2017

Background Women with childhood maltreatment histories are at increased risk for adverse birth outcomes. Mechanisms explaining this link are poorly understood. Past research is limited by sampling pregnant women at low risk for adverse maternal and neonatal outcomes. Methods This pilot study was a secondary data analysis of 24 women with gestational diabetes mellitus; 17% of the sample also reported a maltreatment history. Women provided a blood sample to measure inflammatory cytokines and insulin resistance, and saliva samples to measure diurnal cortisol. Birth outcomes for past and current pregnancies were recorded. Results Histories of maltreatment were associated with elevated interleukin-15 and a marginally greater incidence of preterm delivery in current and past pregnancies. Conclusions This pilot study was the first to demonstrate an association between childhood maltreatment history and inflammatory cytokine levels in pregnant women diagnosed with gestational diabetes mellitus.
Prehospital triage of patients suffering severe dyspnoea using N-terminal pro-brain natriuretic peptide, the PreBNP trial: a randomised controlled clinical trial
Authors: Bøtker Morten T , Jørgensen Maren T , Stengaard Carsten , Seidenfaden Sophie-Charlott , Tarpgaard Mona , Granfeldt Asger , Mortensen Tanja Ø , Grøfte Thorbjørn , Friesgaard Kristian D , Mærkedahl Rikke , Pedersen Anette B , Lundorff Simon , Hansen Troels Martin , Kirkegaard Hans , Christensen Erika F , Terkelsen Christian J 
Published: May 2017

Purpose: The purpose of this study was to examine whether the addition of brain natriuretic peptide measurement to the routine diagnostic work-up by prehospital critical care team physicians improves triage in patients with severe dyspnoea. Methods: Prehospital critical care team physicians randomly assigned patients older than 18 years with severe dyspnoea to routine diagnostic work-up or diagnostic work-up with incorporated point-of-care N-terminal pro-brain natriuretic peptide (NT-proBNP) measurement. The primary endpoint was the proportion of patients with dyspnoea of primary cardiac origin triaged directly to a department of cardiology. Results: A total of 747 patients were randomly assigned and 711 patients consented to participate, 350 were randomly assigned to the NT-proBNP group and 361 to the routine work-up group. NT-proBNP was measured in 90% (315/350) of patients in the NT-proBNP group and in 19% (70/361) of patients in the routine work-up group. There was no difference in the proportion of patients with dyspnoea of primary cardiac origin triaged directly to a department of cardiology between the NT-proBNP group and the routine work-up group (75% vs. 69%, P=0.22) in the intention-to-treat analysis. Sensitivity analysis according to the de facto diagnostics performed showed results consistent with this. No differences in hospital length of stay, intensive care unit admission rates or mortality between the NT-proBNP group and the routine work-up group were observed. Conclusion: Routine supplementary point-of-care measurement of NT-proBNP in patients with severe dyspnoea did not improve triage of patients with dyspnoea primarily caused by heart disease. ClinicalTrials.gov identifier NCT02050282.
Overall survival in patients with lung cancer using a web-application-guided follow-up compared to standard modalities: Results of phase III randomized trial.
Authors: Denis Fabrice , Lethrosne Claire , Pourel Nicolas , Molinier Olivier , Pointreau Yoann , Domont Julien , Bourgeois Hugues Pierre , Senellart Helene , Tremolieres Pierre , Lizee Thibaut , Bennouna Jaafar , Urban Thierry , El Kouri Claude , Charron Alexandre , Septans Anne-Lise , Balavoine Magali , Rolley Cyrielle , Landry Sebastien , Solal-Celigny Philippe , Letellier Christophe 
Published: May 2017

LBA9006 Background: We developed a web-application for an early detection of symptomatic relapse, complications and early supportive care in high-risk lung cancer patients between visits. A dynamical analysis of the weekly self-reported symptoms automatically triggered physician visit. Methods: We performed a national multi-institutional phase 3 prospective randomized study to compare web-application follow-up (experimental arm) for which patient’s self-scored symptoms that were weekly sent (between planned visits) to the oncologist and a clinical routine assessment with a CT-scan (every 3-6 months or at investigator’s discretion - standard arm). High risk lung cancer patients without progression and with a 0-2 performance status (PS) after an initial treatment were included. Maintenance chemotherapy or TKI therapy were allowed. In the experimental arm, an email alert was sent to the oncologist when some predefined clinical criteria were fulfilled: an imaging was then quickly prescribed. Early supportive cares were provided if adequate. The primary endpoint was to detect an improvement of 12% in 9 months survival in favor of the experimental arm (α = 5%, β = 20%, unilateral test). The boundary for declaring superiority with respect to overall survival at the pre-planned interim analysis was a p-value of less than 0.006. The PS at relapse, the quality of life (QOL) and cost-effectiveness were also investigated. Results: 121 patients were included in the intent-to-test survival analysis (90% were stage III/IV, median age: 65 y): 60 (61) in the experimental (standard) arms with equivalent baseline characteristics. Median follow-up was 9 months. Median overall survival in months was 19 (11.8), p=0.0014 (n  =  121; HR  =  0.33; 95 % CI, 0.16-0.67) and the PS at the first relapse was 0-1 for 81.5% (35.3%) of the patients (p<0.001) in the experimental (standard) arm. Conclusions: This trial shows a significant survival improvement using Web-application-guided follow-up that allowed better PS at relapse, earlier supportive care and reduction of routine imaging. QOL and cost analysis results will be presented during the meeting. Clinical trial information: NCT02361099.
Underuse of Radiation Therapy After Breast Conservation Surgery in Puerto Rico: A Puerto Rico Central Cancer Registry–Health Insurance Linkage Database Study
Authors: Chance William W. , Ortiz-Ortiz Karen J. , Liao Kai-Ping , Zavala Zegarra Diego E. , Stauder Michael C. , Giordano Sharon H. , Tortolero-Luna Guillermo , Guadagnolo B. Ashleigh 
Published: May 2017

Purpose To identify rates of postoperative radiation therapy (RT) after breast conservation surgery (BCS) in women with stage I or II invasive breast cancer treated in Puerto Rico and to examine the sociodemographic and health services characteristics associated with variations in receipt of RT. Methods The Puerto Rico Central Cancer Registry–Health Insurance Linkage Database was used to identify patients diagnosed with invasive breast cancer between 2008 and 2012 in Puerto Rico. Claims codes identified the type of surgery and the use of RT. Logistic regression models were used to examine the independent association between sociodemographic and clinical covariates. Results Among women who received BCS as their primary definitive treatment, 64% received adjuvant RT. Significant predictors of RT after BCS included enrollment in Medicare (odds ratio [OR], 2.14; 95% CI, 1.46 to 3.13; P ≤ .01) and dual eligibility for Medicare and Medicaid (OR, 1.61; 95% CI, 1.14 to 2.27; P < .01). In addition, it was found that RT was more likely to have been received in certain geographic locations, including the Metro-North (OR, 2.20; 95% CI, 1.48 to 3.28; P < .01), North (OR, 1.78; 95% CI, 1.20 to 2.64; P < .01), West (OR, 4.04; 95% CI, 2.61 to 6.25; P < .01), and Southwest (OR, 2.79; 95% CI, 1.70 to 4.59; P < .01). Furthermore, patients with tumor size > 2.0 cm and ≤ 5.0 cm (OR, 0.61; 95% CI, 0.40 to 0.93; P = .02) and those with tumor size > 5.0 cm (OR, 0.37; 95% CI, 0.15 to 0.92; P = .03) were found to be significantly less likely to receive RT. Conclusion Underuse of RT after BCS was identified in Puerto Rico. Patients enrolled in Medicare and those who were dually eligible for Medicaid and Medicare were more likely to receive RT after BCS compared with patients with Medicaid alone. There were geographic variations in the receipt of RT on the island.