bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Rare and Emerging Entity: Sinonasal IgG4–related Sclerosing Disease
Authors: Song Brian H. , Baiyee Daniel , Liang Jonathan 
Published: December 2015

Background Immunoglobulin G4 (IgG4) related sclerosing disease (rSD) is a new disease entity, first described in 2001, that involves autoimmune pancreatitis. Considered a systemic disease with lesions described in multiple organ systems, IgG4-rSD that affects the sinonasal region is rare. Our goal was to highlight the sinonasal presentation of this unique disease and to review previously reported adult cases from 2003 to 2014. Methods Case report (a 72-year-old man who presented with left exophthalmos, periorbital pain, and epiphora) and review of the literature. Results Radiographic workup with computed tomography and magnetic resonance imaging demonstrated a left sinonasal mass that involved the left maxillary and ethmoid sinuses, with surrounding bony destruction and orbital invasion. Nasal endoscopy demonstrated a fibrous lesion emanating in the middle meatus, with surrounding mucosal inflammation. The patient underwent an endoscopic biopsy, medial maxillectomy, and ethmoidectomy with tumor debulking. Pathology demonstrated inflamed respiratory mucosa with dense lymphoplasmacytic infiltrate and fibrosis; flow cytometry demonstrated no malignant cell populations; immunophenotyping demonstrated multiple foci of IgG4 cells. Plasma IgG4 was elevated in the setting of normal total IgG. The patient was treated with postoperative systemic and topical corticosteroids. Surveillance imaging studies and nasal endoscopy demonstrated disease resolution without recurrence. Conclusions Sinonasal IgG4-rSD is a rare disease that can present with bony and soft-tissue invasion. This was an exceptional case, with osseous involvement and orbital invasion. Immunohistologic workup is essential for diagnosis. It is important to differentiate this disease from sinonasal tumors. Treatment includes corticosteroids and surgical debulking. Sinonasal IgG4-rSD represents an emerging disease that may present challenges for future rhinologists.
Depletion of Gadolinium burnable poison in a PWR assembly with high burnup fuel
Authors: Refeat R. M. 
Published: December 2015

Abstract
A tendency to increase the discharge burnup of nuclear fuel for Advanced Pressurized Water Reactors (PWR) has been a characteristic of its operation for many years. It will be able to burn at very high burnup of about 70 GWd/t with UO2 fuels. The U-235 enrichment must be higher than 5 %, which leads to the necessity of using an extremely efficient burnable poison like Gadolinium oxide. Using gadolinium isotope is significant due to its particular depletion behavior (“Onion-Skin” effect). In this paper, the MCNPX2.7 code is used to calculate the important neutronic parameters of the next generation fuels of PWR. K-infinity, local peaking factor and fission rate distributions are calculated for a PWR assembly which burn at very high burnup reaching 70 GWd/t. The calculations are performed using the recently released evaluated Gadolinium cross section data. The results obtained are close to those of a LWR next generation fuel benchmark problem. This demonstrates that the calculation scheme used is able to accurately model a PWR assembly that operates at high burnup values.
Thermal hydraulic analysis of reactivity accidents in MTR research reactors using RELAP5
Authors: El-Sahlamy N. , Khedr A. , D’Auria F. 
Published: December 2015

Abstract
The present paper comes in the line with the international approach which use the best estimate codes, instead of conservative codes, to get more realistic prediction of system behavior under off-normal reactor conditions. The aim of the current work is to apply this approach using the thermal-hydraulic system code RELAP5/Mod3.3 in a reassessment of safety of the IAEA benchmark 10 MW Research Reactor. The assessment is performed for both slow and fast reactivity insertion transients at initial power of 1.0 W. The reactor power is calculated using the RELA5 point kinetic model. The reactivity feedback terms are considered in two steps. In the first step the feedback from changes in water density and fuel temperature (Doppler effects) are considered. In the second step the feedback from the water temperature changes is added. The results from the first step are compared with that published in IAEA-TECDOC-643 benchmarks. The comparison shows that RELAP5 over predicts the peak power and consequently the fuel, clad and coolant temperatures in case of fast reactivity insertion. The results from the second step show unjustified values for reactor power. Therefore, the model of reactivity feedback from water temperature changes in the RELAP5 code may have to be reviewed.
Does Concomitant Methotrexate with Adalimumab Influence Treatment Outcomes in Patients with Psoriatic Arthritis? Data from a Large Observational Study
Authors: Behrens Frank , Koehm Michaela , Arndt Uta , Wittig Bianca M. , Greger Gerd , Thaçi Diamant , Scharbatke Eva , Tony Hans-Peter , Burkhardt Harald 
Published: December 2015

Objective.To examine the influence of concomitant methotrexate (MTX) with adalimumab (ADA) on outcomes in patients with psoriatic arthritis (PsA) using data from an observational study of ADA.Methods.Data from a German noninterventional study of patients with PsA starting treatment with ADA were analyzed retrospectively for effects of concomitant MTX on key outcomes, including Disease Activity Score-28 joints, tender and swollen joint counts, skin assessments, and safety. Patients were categorized into those with symptoms of axial involvement and those with no symptoms of axial involvement as judged by the examining clinician.Results.A total of 1455 patients met the study criteria, 296 with axial involvement (ADA monotherapy = 165; plus MTX = 131) and 1159 with no axial involvement (ADA monotherapy = 658; plus MTX = 501). ADA, alone or combined with MTX, resulted in strong and comparable reductions in disease activity measures in patients with and those without axial disease over 24 months of therapy. In multiple regression analyses, concomitant MTX did not affect joint or skin outcomes in either the group with axial manifestations or the group without axial disease. Neither adverse event rates nor withdrawal rates were significantly influenced by concomitant MTX.Conclusion.ADA is an effective treatment option for patients with PsA with or without axial involvement. Compared with ADA monotherapy, the use of concomitant MTX with ADA does not improve articular or skin outcomes in patients with PsA regardless of axial symptoms. Trial registration: Clinicaltrials.govNCT01111240
Anti-carbamylated Protein Antibody Levels Correlate with Anti-Sa (Citrullinated Vimentin) Antibody Levels in Rheumatoid Arthritis
Authors: Challener Gregory J. , Jones Jonathan D. , Pelzek Adam J. , Hamilton B. JoNell , Boire Gilles , de Brum-Fernandes Artur José , Masetto Ariel , Carrier Nathalie , Ménard Henri A. , Silverman Gregg J. , Rigby William F.C. 
Published: December 2015

Objective.The presence of anticitrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA) indicates a breach in immune tolerance. Recent studies indicate that this breach extends to homocitrullination of lysines with the formation of anti-carbamylated protein (anti-CarP) antibodies. We analyzed the clinical and serologic relationships of anti-CarP in 2 RA cohorts.Methods.Circulating levels of immunoglobulin G anti-CarP antibodies were determined by ELISA in established (Dartmouth-Hitchcock Medical Center) and early (Sherbrooke University Hospital Center) cohorts and evaluated for anticyclic citrullinated peptide antibodies (anti-CCP), specific ACPA, and rheumatoid factor (RF) levels using the Student t test and correlation analysis.Results.We identified elevated anti-CarP antibodies titers in 47.0% of seropositive patients (Dartmouth, n = 164), with relationships to anti-CCP (p < 0.0001) and IgM-RF (p = 0.001). Similarly, 38.2% of seropositive patients from the Sherbrooke cohort (n = 171) had elevated anti-CarP antibodies; titers correlated to anti-CCP (p = 0.01) but not IgM-RF (p = 0.09). A strong correlation with anti-Sa was observed: 47.9% anti-Sa+ patients were anti-CarP antibodies+ versus only 25.4% anti-Sa− in the Sherbrooke cohort (p = 0.0002), and 62.6% anti-Sa+ patients versus 26.9% anti-Sa− were anti-CarP antibodies+ in Dartmouth (p < 0.0001). We found a more variable response for reactivity to citrullinated fibrinogen or to citrullinated peptides from fibrinogen and α enolase.Conclusion.In 2 North American RA cohorts, we observed a high prevalence of anti-CarP antibody positivity. We also describe a surprising and unexpected association of anti-CarP with anti-Sa antibodies that could not be explained by cross-reactivity. Further, considerable heterogeneity exists between anti-CarP reactivity and other citrullinated peptide reactivity, raising the question of how the pathogenesis of antibody responses for carbamylated proteins and citrullinated proteins may be linkedin vivo.
Obesity Is Common in Axial Spondyloarthritis and Is Associated with Poor Clinical Outcome
Authors: Maas Fiona , Arends Suzanne , van der Veer Eveline , Wink Freke , Efde Monique , Bootsma Hendrika , Brouwer Elisabeth , Spoorenberg Anneke 
Published: December 2015

Objective.To assess the prevalence of overweight and obesity in a large cohort of patients with axial spondyloarthritis (axSpA) in comparison with the general population. To explore the relationship of body mass index (BMI) with clinical outcome in axSpA.Methods.Patients from the Groningen Leeuwarden Axial SpA cohort who visited the outpatient clinic in 2011/2012 were included in this cross-sectional analysis. Body weight, height, disease activity, physical function, and quality of life (QoL) were assessed. Patients were divided into normal weight (BMI < 25 kg/m2), overweight (BMI ≥ 25 to < 30 kg/m2), and obese (BMI ≥ 30 kg/m2). BMI data for the general population in the same demographic region, matched for age and sex, were obtained from the LifeLines Cohort Study.Results.Of the 461 patients with axSpA, 37% were overweight and 22% were obese. In the LifeLines cohort (n = 136,577), 43% were overweight and 15% were obese. Overweight and obese patients were older, had longer symptom duration, and had more comorbidities, especially hypertension. Further, obese patients had significantly higher disease activity, worse physical function, and worse QoL than overweight and normal weight patients (mean Bath Ankylosing Spondylitis Disease Activity Index 4.5, 3.5, 3.8; mean Ankylosing Spondylitis Disease Activity Score 2.8, 2.2, 2.3; median C-reactive protein 5, 3, 3 mg/l; median erythrocyte sedimentation rate 13, 8, 8 mm/h; median Bath Ankylosing Spondylitis Functional Index 5.2, 2.9, 2.9; median Ankylosing Spondylitis QoL Questionnaire 8, 4, 5, respectively). After adjustment for potential confounders, obesity proved to be an independent predictor of worse clinical outcome.Conclusion.In this large observational cohort study, obesity is more common in axSpA than in the general population and it is associated with worse clinical outcome.
Le dossier du nucléaire iranien et la question du rapprochement États-Unis – Iran
Authors: Zarifian Julien 
Published: December 2015

L’accord sur le nucléaire iranien signé le 14 juillet 2015 entre l’Iran et le « groupe des 5 + 1 » (États-Unis, Russie, Chine, France, Royaume-Uni, Allemagne) constitue un succès majeur, malgré les difficultés rencontrées pendant les négociations et même s’il ne règle pas les désaccords profonds entre l’Iran et la communauté internationale, et en particulier l’Occident. Outre geler le programme nucléaire iranien pour au moins quinze ans et lever l’essentiel des sanctions internationales à l’encontre de Téhéran, il montre les diplomaties américaine et iranienne sous un jour relativement positif et prouve qu’elles peuvent travailler ensemble et obtenir des résultats. Ce faisant, il laisse entrevoir des possibilités de réchauffement des (non -) relations bilatérales américano-iraniennes, mais aussi les obstacles à une telle amélioration des relations.
La relation américano-saoudienne à l’épreuve du rapprochement entre Washington et Téhéran
Authors: Wesser Sébastien 
Published: December 2015

Dans un Moyen-Orient en pleine ébullition, l’administration Obama a gagné son pari, lancé en 2013, de négocier une sortie de crise avec Téhéran afin de maîtriser la menace nucléaire iranienne et de restaurer les relations entre les deux pays après un gel de plus de trente-cinq ans. Ébranlés par le printemps arabe et déstabilisés par les conséquences des inextricables conflits syrien et irakien, les partenaires arabes des États-Unis étaient vent debout contre ce projet. Le Royaume saoudien, pourtant allié historique des États-Unis au Moyen-Orient, se méfie désormais des intentions de Washington. Au-delà de sa volonté de consolider sa puissance militaire, Riyad semble décidé à acquérir également un arsenal nucléaire pour faire face à une potentielle menace nucléaire iranienne. Alors que les deux pays s’affrontent déjà par alliés interposés en Irak ou en Syrie, le conflit yéménite apparaît, de plus en plus, comme un affrontement direct entre Riyad et Téhéran. Washington peut-il résoudre la quadrature du cercle du retour de l’Iran sur les scènes régionale et internationale ?
« Series finale » : enjeux et théorie d’un compromis moderne
Authors: Lifschutz Vladimir 
Published: December 2015

Cet article explore la problématique de la finalité dans une œuvre sérielle. Il s’agit de s’interroger sur les enjeux du series finale, point final d’un vaste projet narratif. En remontant le fil de l’Histoire et en étudiant les changements récents du statut de la fin, nous proposerons une théorie fondée sur l’idée suivante : les fins des séries reposent sur une rupture systématique de la « formule », une « déformulation » dont l’objectif ultime est de permettre à la fiction de passer de sa première diffusion à un second monde plus vaste que nous appellerons le monde de la réappropriation multi-médiatique. Nous mettrons cette théorie au feu de la pratique avec l’exemple de la sitcom Scrubs (diffusée de 2001 à 2008 sur NBC et de 2009-2010 sur ABC). La mutation économique autour des séries télévisées transforme les attentes des chaînes et des studios, offrant ainsi un nouveau rôle à jouer à la fin, celui d’être un liant entre deux modes d’existence.
Lire l’avenir, changer le passé : Rêves et foi en la fiction dans la série Lost
Authors: Hatchuel Sarah 
Published: December 2015

Il s’agira d’étudier les visions religieuses et spirituelles dans la série Lost comme tissus inter- et intra-textuels, et comme signes à décoder par les personnages et par les spectateurs dans une réflexion profonde sur les rapports entre fiction, « réel » et foi dans l’image et le récit.
Projectiles : De l’usage du plan-séquence dans The West Wing
Authors: Lévy Ophir 
Published: December 2015

La série The West Wing se caractérise notamment par ses longs plans-séquences virtuoses au sein desquels les personnages sillonnent l’aile ouest de la Maison-Blanche. Figures de la continuité par excellence, ces plans déplient méthodiquement un territoire où règne en permanence une activité frénétique qui se donne sous la forme de multiples trajectoires. Trajectoires croisées des corps anonymes appartenant à une foule de figurants de passage (assistants, secrétaires, stagiaires) qui, en moins d’une seconde, tels des projectiles, traversent l’écran et disparaissent absorbés par leur tâche. Trajectoires continues des principaux collaborateurs du président, ou du président lui-même, soutenues par des dialogues incessants qui semblent constituer le carburant de leur motricité même. Trajectoires en rafale des mots eux-mêmes, qui fusent à leur tour tels des projectiles au service d’une extraordinaire balistique de la parole. Que suggère cette coextensivité de la marche et de la parole dans The West Wing ? Soulignant la dépense continue et la virtuosité des personnages, l’ivresse du langage ou au contraire sa plus haute performativité, les plans-séquences permettent de rendre sensible la dimension éminemment physique de la parole. Et sans doute ménagent-ils, à leur manière, un accès à l’essence même du politique, la parole se manifestant dans la série en tant qu’elle est action véritable (convaincre, légiférer, gouverner) et non simplement verbiage inconsistant.
La ventilazione non invasiva in Medicina Interna
Authors: Navalesi Guest Editors: P. , Campanini M. , Lari F. , Giorgi Pierfranceschi M. 
Published: December 2015

<p class="titolo"><strong>Legenda delle più comuni abbreviazioni e acronimi</strong> 391</p><p class="titolo"><strong>Prefazione</strong> 393<br /><em>P. Navalesi</em></p><p class="titolo"><strong>Presentazione</strong> 395<br /><em>M. Campanini</em></p><img src="/public/site/images/pgranata/intro.jpg" alt="" /><br /><p class="titolo"><strong>La NIV in Medicina Interna</strong> 396<br /><em>F. Lari</em></p><img src="/public/site/images/pgranata/rass.jpg" alt="" /><br /><p class="titolo"><strong>Il ventilatore e i suoi componenti</strong> 399<br /><em>F. Lari</em></p><p class="titolo"><strong>Maschere ed interfacce</strong> 407<br /><em>F. Lari</em></p><p class="titolo"><strong>Sistemi CPAP (pressione positiva continua applicata alle vie aeree)</strong> 411<br /><em>F. Lari</em></p><p class="titolo"><strong>Principi e tecniche di ventilazione meccanica</strong> 417<br /><em>F. Giostra, E. Di Flaviano</em></p><p class="titolo"><strong>Insufficienza respiratoria acuta cardiogena - ruolo della ventilazione non invasiva</strong> 427<br /><em>F. Ventrella</em></p><p class="titolo"><strong>Riacutizzazione di broncopneumopatia cronica ostruttiva</strong> 443<br /><em>M. La Regina, F. Orlandini</em></p><p class="titolo"><strong>Altre indicazioni alla ventilazione meccanica non invasiva</strong> 451<br /><em>F. Pieralli, O. Para, C. Nozzoli</em></p><p class="titolo"><strong>Le apnee del sonno: competenza multidisciplinare e ruolo dell’internista</strong> 456<br /><em>F. Lari</em></p><p class="titolo"><strong>La ventilazione meccanica non invasiva nella palliazione del paziente oncologico terminale</strong> 462<br /><em>S. Orlando, M. Giorgi-Pierfranceschi</em></p><p class="titolo"><strong>La NIV nel paziente con insufficienza respiratoria cronica, la gestione domiciliare - Competenza specialistica nelle patologie pneumologiche pure</strong> 465<br /><em>A. Marchioni, E.M. Clini, B. Beghé</em></p><p class="titolo"><strong>Approccio al paziente internistico, candidato alla ventilazione meccanica non invasiva: <em>key messages</em></strong> 475<br /><em>M. Giorgi Pierfranceschi</em></p><img src="/public/site/images/pgranata/concl.jpg" alt="" /><p class="titolo"><strong>La ventilazione meccanica non invasiva: conclusioni</strong> 482<br /><em>M. Errico, A. Greco</em></p><img src="/public/site/images/pgranata/appendix.jpg" alt="" /><br /><p class="titolo"><strong>NIV in Medicina Interna: sono necessari sistemi di monitoraggio emodinamico?</strong> 484<br /><em>N. Di Battista, F. Savelli</em></p>
The Ecological Implications of Martin Buber's Zionism: The Myth of Zion in Martin Buber's Thought
Authors: Breslauer S. Daniel 
Published: December 2015

ABSTRACTSeveral theories about Jewish ethical reflection and ecological ethics compete for attention. Some theorists do utilize Martin Buber's thinking, both his general philosophy and his specific writings about Zion. Looking at Buber's approach to Zion as a myth helps focus his thinking, particularly in relationship to the diverse views in current Jewish thought. This paper examines Buber's view of myth, his discussion of the myth of Zion, and the implications of this mythic approach to ecological ethics.
Skryté kurikulum, žité příběhy. Narativy studentů učitelství o škole
Authors: Lojdová Kateřina 
Published: December 2015

Empirická studie je věnována skrytému kurikulu v příbězích o zkušenostech studentů učitelství se školou. Výsledkem narativní analýzy 88 studentských vyprávění je identifikace dvou typů skrytého kurikula. Kritériem pro typologii je to, zda se skryté kurikulum utváří mezi aktéry na různých sociálních pozicích ve škole, mezi kterými je hierarchický vztah, nebo mezi aktéry na stejných sociálních pozicích ve škole, mezi kterými je vztah nehierarchický. První typ je označen jako vertikální skryté kurikulum a utváří se mezi aktéry na odlišných sociálních pozicích ve škole, tedy nejčastěji mezi učiteli a žáky. Vertikální skryté kurikulum odhaluje konflikty mezi žáky a školou, které se objevují zejména v hodnotové rovině, dále pak rituály, kterými škola hodnoty prosazuje, s tím související podobu moci školy a rezistence žáků vůči této moci. V neposlední řadě je součástí vertikálního skrytého kurikula také bezmoc školy, a to v situacích, kdy mají žáci ve škole mocenskou převahu. Druhý typ skrytého kurikula je označen jako horizontální skryté kurikulum a vztahuje se k aktérům na stejných sociálních pozicích, tedy k žákovskému kolektivu. Opět se týká zejména hodnot, které se žáci ve škole učí, tentokrát však ve třídním kolektivu. Dochází zde k vzájemnému vyjednávání identit žáků. V neposlední řadě je zachyceno, jak do žákovských vztahů zasahují učitelé, kteří tak proměňují obsah horizontálního skrytého kurikula. Závěrem je diskutován význam zkušeností ze skrytého kurikula v průběhu povinné školní docházky pro budoucí učitele.
Pedagogika a paradigmatický obrat v metodologii a teorii
Authors: Šíp Radim 
Published: December 2015

Příspěvek popisuje paradigmatický obrat, který pozměňuje raně moderní východiska vědy. Opouští objektivistický realismus a korespondenční teorii pravdy a poznání. V textu autor představuje pragmatistickou teorii poznání (Dewey) a závěry pozdní fenomenologie (Merleau-Ponty, Barbaras, Ricoeur), která znovu objevuje faktické kořeny transcendentální roviny. Oba směry zdůrazňují vliv tělesnosti na proces poznání, což vede k závazkům, jež významně proměňují metafyzická východiska moderní vědy. Změny, které autor popisuje, se dotýkají jak metodologické, tak teoretické roviny. Na rovině metodologie autor poukazuje na to, jak je rozpouštěna příliš striktní hranice mezi přírodními a sociálními vědami a mezi kvantitativní a kvalitativní metodologií, a dokládá potřebu nahradit tato rozdělení tzv. „kontinuitou disciplinovaného vědeckého výzkumu“. Na teoretické rovině autor popisuje změnu role teorie a význam, jaký v této proměně hraje znovuobjevení somatické dimenze lidského poznání. Všechny tyto změny zásadně proměňují sebereflexi vědy jak na obecné úrovni, takna úrovni jednotlivých disciplín – tedy i v pedagogice.
Akademikui Pranui Mažyliui – 130
Authors: Basys Vytautas , Olechnovičienė Jadvyga 
Published: December 2015

2015 m. sausio 24 d. – Lietuvos mokslų akademijos (LMA) tikrojo nario, profesoriaus, mokslų daktaro Prano MAŽYLIO 130 gimimo metų sukaktis. Ta proga išleistas proginis vokas, Lietuvos sveikatos mokslų universiteto Akušerijos ir ginekologijos klinika kartu su Kauno krašto akušerių ginekologų draugija Lietuvos medicinos ir farmacijos istorijos muziejuje 2015 m. vasario 5 d. organizavo mokslinę konferenciją „Gyvenimas kaip legenda. Akademikas Pranas Mažylis, 1885–1966“, atidarė parodą „Akademikas profesorius Pranas Mažylis – Lietuvos akušerijos ir ginekologijos mokyklos įkūrėjas, gimdymo pagalbos organizatorius, klinicistas, pedagogas“.
Straipsnyje pateikiami svarbiausieji Lietuvos mokslų akademijos akademiko Prano Mažylio gyvenimo etapai ir jo veikla dirbant Akademijos institutuose, komisijose, vadovavimas moksliniams tyrimams ir šių tyrimų svarbiausi rezultatai.
Cartografia social: o mapa como construção cultural e exercício do poder
Authors: Santos Jadson de Jesus , Silva Gicélia Mendes da 
Published: December 2015

Este artigo é produto da dissertação de mestrado em Desenvolvimento e Meio Ambiente da Universidade Federal de Sergipe. O trabalho traz um descritivo histórico sobre os diversos tipos de cartografias, incluindo a cartografia social e a utilização delas nos diversos processos de formação histórica da sociedade através das diversas culturas e da formação dos diversos poderes exercidos.