bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spiral volumetric optoacoustic tomography of reduced oxygen saturation in the spinal cord of M83 mouse model of Parkinson’s disease
Authors: Combes Benjamin F. , Kalva Sandeep Kumar , Benveniste Pierre-Louis , Tournant Agathe , Law Man Hoi , Newton Joshua , Krüger Maik , Weber Rebecca Z. , Dias Inês , Noain Daniela , Dean-Ben Xose Luis , Konietzko Uwe , Baumann Christian R. , Gillberg Per-Göran , Hock Christoph , Nitsch Roger M. , Cohen-Adad Julien , Razansky Daniel , Ni Ruiqing 
Published: October 2024

Abstract

Purpose
Metabolism and bioenergetics in the central nervous system play important roles in the pathophysiology of Parkinson’s disease (PD). Here, we employed a multimodal imaging approach to assess oxygenation changes in the spinal cord of the transgenic M83 murine model of PD overexpressing the mutated A53T alpha-synuclein form in comparison with non-transgenic littermates.

Methods
In vivo spiral volumetric optoacoustic tomography (SVOT) was performed to assess oxygen saturation (sO2) in the spinal cords of M83 mice and non-transgenic littermates. Ex vivo high-field T1-weighted (T1w) magnetic resonance imaging (MRI) at 9.4T was used to assess volumetric alterations in the spinal cord. 3D SVOT analysis and deep learning-based automatic segmentation of T1w MRI data for the mouse spinal cord were developed for quantification. Immunostaining for phosphorylated alpha-synuclein (pS129 α-syn), as well as vascular organization (CD31 and GLUT1), was performed after MRI scan.

Results
In vivo SVOT imaging revealed a lower sO2
SVOT in the spinal cord of M83 mice compared to non-transgenic littermates at sub-100 μm spatial resolution. Ex vivo MRI-assisted by in-house developed deep learning-based automatic segmentation (validated by manual analysis) revealed no volumetric atrophy in the spinal cord of M83 mice compared to non-transgenic littermates at 50 μm spatial resolution. The vascular network was not impaired in the spinal cord of M83 mice in the presence of pS129 α-syn accumulation.

Conclusion
We developed tools for deep-learning-based analysis for the segmentation of mouse spinal cord structural MRI data, and volumetric analysis of sO2
SVOT data. We demonstrated non-invasive high-resolution imaging of reduced sO2
SVOT in the absence of volumetric structural changes in the spinal cord of PD M83 mouse model.
Genetic variants in patients with multiple arterial aneurysms
Authors: Körfer Daniel , Grond-Ginsbach Caspar , Peters Andreas S. , Burkart Sebastian , Hempel Maja , Schaaf Christian P. , Böckler Dittmar , Erhart Philipp 
Published: October 2024

Abstract

Purpose
The aim of this study was to identify causal genetic variants in patients with multiple arterial aneurysms.

Methods
From a total cohort of 3107 patients diagnosed with an arterial aneurysm from 2006 to 2016, patients with known hereditary connective tissue diseases, vasculitis, or other arterial pathologies (n = 918) were excluded. Of the remaining cohort (n = 2189), patients with at least 4 aneurysms at different arterial locations (n = 143) were included. Nine blood samples of respective patients were available and derived from the institutional vascular biomaterial bank, and analyzed by whole exome sequencing (WES). Possible candidate variants were selected based on in silico predictions: (I) Truncating variants or (II) Variants that were classified as likely pathogenic (SIFT score < 0.05 or PolyPhen score > 0.9) and with low (< 0.001) or unknown gnomAD allele frequency. The human genome databases GeneCards and MalaCards were used to correlate the variants with regard to possible associations with vascular diseases.

Results
A total of 24 variants in 23 different genes associated with vascular diseases were detected in the cohort. One patient with eight aneurysms was heterozygous for a variant in SMAD3, for which pathogenic variants are phenotypically associated with Loeys-Dietz syndrome 3. A heterozygous variant in TNXB was found in a patient with five aneurysms. Homozygous or compound heterozygous pathogenic variants in this gene are associated with Ehlers-Danlos syndrome (classical-like). Another patient with six aneurysms carried two heterozygous TET2 variants together with a heterozygous PPM1D variant. Pathogenic variants in these genes are associated with clonal hematopoiesis of indeterminate potential (CHIP), a known risk factor for cardiovascular disease.

Conclusion
All nine patients in this study carried variants in genes associated with vascular diseases. Current knowledge of the specific variants is insufficient to classify them as pathogenic at the present time, underlining the need for a better understanding of the consequences of genetic variants. WES should be considered for patients with multiple arterial aneurysms to detect germline variants and to improve clinical management for the individual and family members.
The effect of laparoscopic vertical sleeve gastrectomy and laparoscopic roux-en-Y gastric bypass on gastroesophageal reflux disease: An updated meta-analysis and systematic review of 5-year post-operative data from randomized controlled trials
Authors: Memon Muhammed Ashraf , Osland Emma , Yunus Rossita Mohamad , Hoque Zahirul , Alam Khorshed , Khan Shahjahan 
Published: October 2024

Abstract
Background
To evaluate 5-year effect of laparoscopic vertical sleeve gastrectomy (LVSG) versus laparoscopic roux-en-Y gastric bypass (LRYGB) on gastroesophageal reflux disease (GERD) solely based on randomized controlled trials (RCTs).

Methods
A systematic review and meta-analysis of 5-year postoperative GERD data comparing LVSG and LRYGB in adults were undertaken. Electronic databases were searched from January 2015 to March 2024 for publications meeting inclusion criteria. The Hartung–Knapp–Sidik–Jonkman random effects model was applied to estimate pooled odds ratio where meta-analysis was possible. Bias and certainty of evidence were assessed using the Cochrane Risk of Bias Tool 2 and GRADE.

Results
Five RCTs were analysed (LVSG n = 554, LRYGB n = 539). LVSG was associated with increased adverse GERD outcomes compared to LRYGB at 5 years. The odds for revisional surgery to treat GERD in LVSG patients were 11 times higher compared to LRYGB (OR 11.47, 95% CI 1.83 to 71.69; p = 0.02; I2 = 0% High level of certainty). Similarly pharmacological management for increasing GERD was significantly more frequent in LVSG patients compared to LRYGB (OR 3.89, 95% CI 2.31 to 6.55; p ≤ 0.01; I2 = 0% Moderate level of certainty). Overall, LVSG was associated with significantly more interventions (both medical and surgical) for either worsening GERD and/or development of de novo GERD compared to LRYGB (OR 5.98, 95% CI 3.48 to 10.29; p ≤ 0.01; I2 = 0%) Moderate level of certainty).

Conclusions
The development and worsening of GERD symptoms are frequently associated with LVSG compared to LRYGB at 5 years postoperatively requiring either initiation or increase of pharmacotherapy or failing that revisional bariatric surgery. Appropriate patient/surgical selection is crucial to reduce these postoperative risks of GERD.
Near-infrared autofluorescence pattern in parathyroid gland adenoma
Authors: Rossi Leonardo , De Palma Andrea , Papini Piermarco , Chicas Vasquez Malince , Cetani Filomena , Ambrosini Carlo Enrico , Materazzi Gabriele 
Published: October 2024

Abstract
Background
Parathyroid gland (PG) surgery is often challenging due to the small size and indistinct nature of these glands. The introduction of intraoperative near-infrared autofluorescence (NIRAF) has shown promise in localizing parathyroid tissue. However, the NIRAF features of parathyroid adenomas remain unclear. The aim of this study is to assess the NIRAF pattern of parathyroid adenomas.

Methods
Patients who underwent surgery for primary hyperparathyroidism at the University Hospital of Pisa, Endocrine Surgery Unit, between December 2021 and February 2022 were enrolled in this study. Intraoperative NIRAF patterns of suspected parathyroid adenomas were evaluated, with particular attention given to the presence of a bright cap.

Results
A retrospective study was conducted on 11 patients with primary hyperparathyroidism who underwent parathyroidectomy at our institution. Histopathological examination of the 15 resected specimens confirmed 14 parathyroid adenomas (12 chief cell parathyroid adenomas, 1 oxyphil cell parathyroid adenoma, and 1 mixed cell parathyroid adenoma) and one schwannoma. All adenomas exhibited a heterogeneous NIRAF pattern, distinct from the homogeneous pattern observed in the schwannoma. A bright cap was identified in 9 out of 14 (64.3%) parathyroid adenomas (all chief cell adenomas). On the contrary, all 9 macroscopically normal PGs identified during surgery presented an homogeneous pattern.

Conclusion
Our findings support the integration of NIRAF into parathyroid surgical procedures. The heterogeneous NIRAF pattern observed in parathyroid adenomas, often accompanied by a bright cap, offers a promising intraoperative diagnostic tool to differentiate hyperfunctioning from normal parathyroid tissue. Larger-scale randomized trials are warranted to further validate these findings.
Interdisziplinäre multimodale Schmerztherapie: Macht die Dosis einen Unterschied?
Authors: Baumbach Philipp , Storch Peter , Weiss Thomas , Meissner Winfried , Rottstädt Fabian 
Published: October 2024

Zusammenfassung
Hintergrund
Die interdisziplinäre multimodale Schmerztherapie (IMST) gilt als etablierte Behandlung bei Patient:innen mit starken chronischen Schmerzen. Über die Rolle der Dosierung der Behandlung und insbesondere hinsichtlich des Zusammenhangs der Dauer der IMST und des Behandlungserfolgs liegen kaum Erkenntnisse vor.

Ziel
Ziel dieser retrospektiven Studie war es, den mittelfristigen Behandlungserfolg einer kurzen stationären (KST, 1 Woche) und einer langen tagesklinischen (LTT, 4 Wochen) IMST mit vergleichbarem inhaltlichem Behandlungskonzept und vergleichbarer Therapieintensität (20 h/Woche) bei Patient:innen mit starken chronischen Schmerzen zu vergleichen.

Methoden
Patient:innen beider Gruppen beantworteten jeweils zu Beginn und zum Ende der IMST sowie nach 3 Monaten den Deutschen Schmerzfragebogen. Die primären Zielgrößen umfassten die schmerzbedingte Beeinträchtigung und die durchschnittliche Schmerzintensität im Follow-up bei zu Therapiebeginn hinsichtlich Geschlecht, Alter, Schmerzintensität und -beeinträchtigung vergleichbaren Patient:innen.

Ergebnisse
Während initial beide Gruppen signifikante Behandlungseffekte in der schmerzbedingten Beeinträchtigung und durchschnittlichen Schmerzintensität zeigten, berichteten im 3‑Monats-Follow-up Patient:innen der LTT (n = 32) signifikant bessere Werte in beiden Variablen im Vergleich zu Patient:innen der KST (n = 32). Dies war auf anhaltende positive Effekte bei LTT-Patient:innen und eine Verschlechterung in der KST-Gruppe zurückzuführen.

Schlussfolgerung
Die Ergebnisse deuten darauf hin, dass initiale Behandlungseffekte in beiden Behandlungssettings zu beobachten sind, eine längere Therapiedauer aber scheinbar die langfristige Stabilität der Behandlungseffekte begünstigt.

Graphic abstract
Die räumliche Dimension des EU-Emissionshandels (EU ETS): Messung des regionalen Transformationsdrucks in Deutschland
Authors: Becker Tim , Losacker Sebastian 
Published: October 2024

ZusammenfassungUm die Wirtschaft in eine emissionsarme Zukunft zu führen und den Klimawandel einzudämmen, wurde auf europäischer Ebene das EU-Emissionshandelssystem (EU ETS) eingeführt. Es funktioniert über einen Cap-and-Trade-Mechanismus und reguliert derzeit etwa 40 % der CO2-Emissionen in der EU. Aufgrund regionaler Unterschiede in der Industriestruktur und der räumlichen Konzentration regulierter Anlagen kann dieses supranationale Instrument jedoch regional unterschiedliche Wirkungen entfalten und zu einer räumlich ungleichen Verteilung des Kostendrucks zur Emissionsminderung führen. Um diesen Transformationsdruck für deutsche NUTS-3-Regionen empirisch zu messen, schlagen wir zwei Indikatoren vor: einen zur Messung der regionalen CO2-Intensität und einen zur Messung der regionalen regulatorischen Stringenz. Eine anschließende Regionstypisierung auf Basis beider Indikatoren bietet eine Orientierungshilfe, in welchen Regionen Strukturwandel, Abwanderung von Unternehmen oder Verlagerung emissionsintensiver Produktionsschritte aktuell und in Zukunft zu erwarten sind. Dies hilft dabei die unterschiedlichen Dimensionen des Transformationsdrucks auf die regionale Wirtschaftsstruktur zu approximieren, Zielregionen für zukunftsgerichtete Transformationsstrategien zu identifizieren und regionsspezifische Unterstützungsmaßnahmen zu entwickeln.
Cuts and semidefinite liftings for the complex cut polytope
Authors: Sinjorgo Lennart , Sotirov Renata , Anjos Miguel F. 
Published: October 2024

AbstractWe consider the complex cut polytope: the convex hull of Hermitian rank 1 matrices$$xx^\textrm{H}$$xxH, where the elements of$$x \in \mathbb {C}^n$$x∈Cnaremth unit roots. These polytopes have applications in MAX-3-CUT, digital communication technology, angular synchronization and more generally, complex quadratic programming. For$$m=2$$m=2, the complex cut polytope corresponds to the well-known cut polytope. We generalize valid cuts for this polytope to cuts for any complex cut polytope with finite$$m>2$$m>2and provide a framework to compare them. Further, we consider a second semidefinite lifting of the complex cut polytope for$$m=\infty $$m=∞. This lifting is proven to be equivalent to other complex Lasserre-type liftings of the same order proposed in the literature, while being of smaller size. Our theoretical findings are supported by numerical experiments on various optimization problems.
Exploring forest changes in an Ips typographus L. outbreak area: insights from multi-temporal multispectral UAS remote sensing
Authors: Östersund Madeleine , Honkavaara Eija , Oliveira Raquel A. , Näsi Roope , Hakala Teemu , Koivumäki Niko , Pelto-Arvo Mikko , Tuviala Johanna , Nevalainen Olli , Lyytikäinen-Saarenmaa Päivi 
Published: October 2024

AbstractUncrewed Aerial Systems (UAS) offer a versatile solution for monitoring forest ecosystems. This study aimed to develop and assess an individual tree-based methodology using multi-temporal, multispectral UAS images to track changes caused by the European spruce bark beetle (Ips typographus L.). The approach encompassed four key steps: (1) individual tree detection using structure-from-motion point clouds, (2) tree species classification, (3) health classification of spruce trees as healthy, declined, or dead, and (4) change detection, identifying fallen/removed trees and alterations in tree health status. The developed methodology was employed to quantify changes in a bark beetle outbreak area covering 215 hectares in southeastern Finland during 2019–2021. The dataset included two managed and two conserved forest areas. The uncertainty estimation demonstrated the overall accuracies ranging from 0.58 to 0.91 for individual tree detection, 0.84 for species classification, and 0.83–0.96 for health classification, and a F1-score of 0.91 for the fallen or removed tree detection. Maps and statistics were produced, containing information on the health of the spruce trees in the area and information on changes, including trees that died during monitoring and those that fell or were removed from the forest. The results demonstrated successful control of the outbreak in the managed stands, evidenced by moderate tree mortality. Conversely, in the conserved stands, the outbreak resulted in dramatic tree mortality. This method serves stakeholders by enabling large-scale outbreak impact monitoring, facilitating timely risk assessment, and validating bark beetle outbreak management strategies.
Multifaceted roles of mitochondria in asthma
Authors: Zhang Wei , Zhang Chenyu , Zhang Yi , Zhou Xuehua , Dong Bo , Tan Hong , Su Hui , Sun Xin 
Published: October 2024

AbstractMitochondria are essential organelles within cells, playing various roles in numerous cellular processes, including differentiation, growth, apoptosis, energy conversion, metabolism, and cellular immunity. The phenotypic variation of mitochondria is specific to different tissues and cell types, resulting in significant differences in their function, morphology, and molecular characteristics. Asthma is a chronic, complex, and heterogeneous airway disease influenced by external factors such as environmental pollutants and allergen exposure, as well as internal factors at the tissue, cellular, and genetic levels, including lung and airway structural cells, immune cells, granulocytes, and mast cells. Therefore, a comprehensive understanding of the specific responses of mitochondria to various external environmental stimuli and internal changes are crucial for elucidating the pathogenesis of asthma. Previous research on mitochondrial-targeted therapy for asthma has primarily focused on antioxidants. Consequently, it is necessary to summarize the multifaceted roles of mitochondria in the pathogenesis of asthma to discover additional strategies targeting mitochondria in this context. In this review, our goal is to describe the changes in mitochondrial function in response to various exposure factors across different cell types and other relevant factors in the context of asthma, utilizing a new mitochondrial terminology framework that encompasses cell-dependent mitochondrial characteristics, molecular features, mitochondrial activity, function, and behavior.
A new argument for linguistic determinants of human thought
Authors: Hinzen Wolfram , Martin Txuss , Wiltschko Martina 
Published: October 2024

AbstractWe argue that the commonly accepted existence of grammatical concepts such as Person (in the grammatical sense) or Tense poses an unrecognized challenge to the idea that human thought is independent of language. The argument is that such concepts identify aspects of linguistic expressions that also systematically define the contents and identity of the thoughts expressed in language. Since grammatical concepts are not known to have non-grammatical analogues, the thoughts in question do not appear to be non-linguistic in nature. We conclude that language is unlikely to be merely a medium in which independently constituted thoughts are expressed.
Numerical modeling of SNSPD absorption utilizing optical conductivity with quantum corrections
Authors: Baránek Martin , Neilinger Pavol , Kern Samuel , Grajcar Miroslav 
Published: October 2024

AbstractSuperconducting nanowire single-photon detectors are widely used in various fields of physics and technology, due to their high efficiency and timing precision. Although, in principle, their detection mechanism offers broadband operation, their wavelength range has to be optimized by the optical cavity parameters for a specific task. We present a study of the optical absorption of a superconducting nanowire single photon detector with an optical cavity. The optical properties of the niobium nitride films, measured by spectroscopic ellipsometry, were modeled using the Drude–Lorentz model with quantum corrections. The numerical simulations of the optical response of the detectors show that the wavelength range of the detector is not solely determined by its geometry, but the optical conductivity of the disordered thin metallic films contributes considerably. This contribution can be conveniently expressed by the ratio of imaginary and real parts of the optical conductivity. This knowledge can be utilized in detector design.
Effect of noisy environment on secure quantum teleportation of unimodal Gaussian states
Authors: Mehrabankar S. , Mahmoudi P. , Abbasnezhad F. , Afshar D. , Isar A. 
Published: October 2024

AbstractQuantum networks rely on quantum teleportation, a process where an unknown quantum state is transmitted between sender and receiver via entangled states and classical communication. In our study, we utilize a continuous variable two-mode squeezed vacuum state as the primary resource for quantum teleportation, shared by Alice and Bob, while exposed to a squeezed thermal environment. Secure quantum teleportation necessitates a teleportation fidelity exceeding 2/3 and the establishment of two-way steering of the resource state. We investigate the temporal evolution of steering and teleportation fidelity to determine critical parameter values for secure quantum teleportation of a coherent Gaussian state. Our findings reveal constraints imposed by temperature, dissipation rate, and squeezing parameters of the squeezed thermal reservoir on the duration of secure quantum teleportation. Intriguingly, we demonstrate that increasing the squeezing parameter of the initial state effectively extends the temporal window for a successful secure quantum teleportation.
Catalytic functionalization of MCM-41 and MCM-48 with copper by modified template ion-exchange method for low-temperature NH3-SCR process: the role of complexing agents for copper dispersion
Authors: Gomułka Aleksandra , Iwaszko Oliwia , Kowalczyk Andrzej , Piwowarska Zofia , Rutkowska Małgorzata , Chmielarz Lucjan 
Published: October 2024

AbstractMesoporous silicas of MCM-41 and MCM-48 types were synthesized and modified with copper by template ion-exchange (TIE) technique. A high dispersion of deposited copper species was managed by subsequent treatment of the samples with ammonia, urea, or acetonitrile solution. Copper-modified silicas were analysed in terms of their chemical composition (ICP-OES), ordering of porous structure (XRD), textural parameters (low-temperature N2 sorption), dispersion and form of introduced copper species (UV–vis-DR, XRD, H2-TPR, NH3-TPD). Mesoporous silicas modified with copper exhibited promising catalytic efficiency in selective catalytic reduction of NO with ammonia (NH3-SCR). The samples containing dispersed copper species (predominantly monomeric copper cations) presented enhanced catalytic activity compared to catalysts containing CuO aggregates. On the other hand, CuO aggregates showed greater catalytic activity in the side process of direct ammonia oxidation by oxygen present in the reaction mixture. It was demonstrated that TIE post-treatment of the samples with urea resulted in most effective improving dispersion of deposited copper and is less destructive for ordered porous structures of mesoporous silica comparing to treatment with ammonia solution.
Graphical abstract
Tuning diagonal scale matrices for HMC
Authors: Tran Jimmy Huy , Kleppe Tore Selland 
Published: October 2024

AbstractThree approaches for adaptively tuning diagonal scale matrices for HMC are discussed and compared. The common practice of scaling according to estimated marginal standard deviations is taken as a benchmark. Scaling according to the mean log-target gradient (ISG), and a scaling method targeting that the frequency of when the underlying Hamiltonian dynamics crosses the respective medians should be uniform across dimensions, are taken as alternatives. Numerical studies suggest that the ISG method leads in many cases to more efficient sampling than the benchmark, in particular in cases with strong correlations or non-linear dependencies. The ISG method is also easy to implement, computationally cheap and would be relatively simple to include in automatically tuned codes as an alternative to the benchmark practice.