bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kajian Alokasi Kebutuhan Ruang di Provinsi Sumatera Utara
Authors: Pinem Dessy Eresina , Sianipar Bambang Benediktus , Purnama Purnama 
Published: June 2016

<p class="Abstract"><em>In line with the development </em><em>of the city, the insistence on changes to the natural spaces and undeveloped land</em><em>s, such as </em><em>for housing, offices, shops, roads and parking </em><em>space, and others becomes higher. </em><em>This condition will effect the decreasing of space for agriculture, vegetables planting and horticulture. On the other side, products of agriculture and horticulture are needed for food. A special case in North Sumatera, the development of highlight/featured sector (rubber and palm planting) also need more space. </em> So, <em>thereupon a competition to get land between many activities in North Sumatera. </em><em>The purpose of research is to analyze the need for space in North Sumatra </em><em>Province in comparison to the availability and suitability of </em><em>the land. In this study, the requirement </em><em>of space is calculated by the amount of the food needs of the entire population of North Sumatra Province which is adapted to Target Consumption of Food Top North Sumatra Province in 2025, the amount of land area required for settlements that are tailored to the population of North Sumatra Province in 2025, the amount of land area needed for the development of the production of palm oil plantations </em><em>as the leading sectors of North Sumatra Province, the vast amount of land required for the development of agricultural production and horticulture to meet the needs of residents of North Sumatra Province until</em><em> 2025. Forecasting the number of agricultural production </em><em>is using simple linear regression. Suitability and land capability </em><em>are measured through the depiction </em><em>of Unit Ability Land (</em>SKL<em>) that will show</em><em> the suitability of land </em><em>for protected areas, residential areas, forests, mangroves, cattle grazing, agriculture annuals, perennial plants, and </em><em>others. </em><em>The result</em><em>s of </em><em>the analysis showed that there will be a shortage of land for agriculture in 2025 in the amount of 596,485.44 ha due to the conversion of agricultural land to residential areas, plantations, and others. Based on the suitability of land for agricultural seasonal wet and dry land, </em><em>there are 1,410,363.07 hectares of land are appropriate for planting vegetables</em><em> in 2025. In 2025</em><em>, also will be a shortage of land for housing amounted to 185,638.54 ha. Another finding is that if productivity remains, then by 2025, rice production in North Sumatra Province can meet the needs of rice for food security as long as the harvest of the land until 2025 is provided. </em><em></em></p>
The role of Pazopanib in Soft Tissue Sarcoma: A comprehensive review of the literature
Authors: Fotopoulos George , Pentheroudakis George 
Published: June 2016

Abstract
INTRODUCTION: Sarcomas are a rare and heterogeneous group of tumours of mesenchymal origin. Single agent pazopanib showed activity in a phase II clinical trial designed to screen various soft tissue sarcoma subtypes [10] and a phase III [11] clinical trial followed resulting in FDA approval in 2012 for use in metastatic soft tissue sarcoma exposed to prior chemotherapy.
METHODS: We conducted an independent computerised review of PubMed and ScienceDirect database up to May 2015 using combinations of terms such as soft tissue sarcoma, pazopanib, STS ,VEGFR2, TKIs ,angiogenesis, advanced sarcoma treatment, targeted therapy for sarcoma
AIM: Our aim was to explore the role of pazopanib in soft tissue sarcoma (STS) treatment, its mode of action, the clinical trials supporting its approval, safety and efficacy, how the product fits into the real world and its contribution to the development of targeted therapy for STS
CONCLUSION: Pazopanib is a valid, innovative and cost-effective approach in the treatment of advanced pre-treated STS
Vocabulary of concepts and terms in chemometrics (IUPAC Recommendations 2016)
Authors: Hibbert David B. 
Published: June 2016

Abstract
Recommendations are given concerning the terminology relating to chemometrics. Building on ISO definitions of terms for basic concepts in statistics the vocabulary is concerned with mainstream chemometric methods. Where methods are used widely in science, definitions are given that are most useful to chemical applications. Vocabularies are given for general data processing, experimental design, classification, calibration and general multivariate methods.
Synthesis of glucopyranos-6′-yl purine and pyrimidine isonucleosides as potential cholinesterase inhibitors. Access to pyrimidine-linked pseudodisaccharides through Mitsunobu reaction
Authors: Batista Daniela , Schwarz Stefan , Loesche Anne , Csuk René , Costa Paulo J. , Oliveira M. Conceição , Xavier Nuno M. 
Published: June 2016

Abstract
The synthesis of new isonucleosides comprising purine and pyrimidine-derived systems linked to methyl glucopyranosidyl units at C-6 and evaluation of their cholinesterase inhibitory profiles is reported. Their access was based on the Mitsunobu coupling of partially acetylated and benzylated methyl glucopyranosides with purine and pyrimidine derivatives. While the reactions with purines and theobromine proceeded with complete regioselectivity, affording exclusively N9- or N1-linked 6′-isonucleosides, respectively, the use of pyrimidine nucleobases led to N1 and/or N3-glucopyranosid-6′-yl pyrimidines and/or to N1,N3/2-O,4-O-pyrimidine-linked pseudodisaccharides through bis-coupling, depending on the substitution pattern of the sugar precursor and on the nature of the nucleobase. From this series of compounds, four were shown to be effective and selective inhibitors of acetylcholinesterase with inhibition constants in the micromolar concentration range. A tri-O-acetylated N1-glucopyranosid-6′-yl theobromine and a benzylated N1,N3-bis-glucopyranosid-6-yl thymine were the most active molecules with K
i values of 4 μM. A tri-O-benzylated glucopyranosid-6′-yl uracil displayed good and selective inhibition of butyrylcholinesterase (K
i=8.4±1.0 μM), similar to that exhibited by the standard galantamine. Molecular docking simulations, performed with the two most effective acetylcholinesterase inhibitors, showed interactions with key amino acid residues located at the enzyme’s active site gorge, which explain the competitive component of their inhibitory activities.
Mechanistic aspects of the stereospecific reduction of chiral hydroxyalkyl phosphinates and phosphine oxides
Authors: Lemouzy Sébastien , Nguyen Duc Hanh , Gatineau David , Giordano Laurent , Hérault Damien , Buono Gérard 
Published: June 2016

Abstract
We present recent advances in the understanding of the reduction of optically pure hydroxyalkylphosphinates and phosphine oxides, which represent key intermediates for the preparation of P-stereogenic ligands. Their reduction leads to P-chiral phosphinites and phosphines, respectively, and occurs stereospecifically with inversion of configuration using BH3·THF, which plays three roles: activating, reducing and protecting agent. The formation of by-products as hydroxyalkyl secondary phosphine–boranes has also been studied.
An easy approach to dihydrochalcones via chalcone in situ hydrogenation
Authors: Jesus Ana R. , Marques Ana P. , Rauter Amélia P. 
Published: June 2016

Abstract
Dihydrochalcones are polyphenols that exhibit a diversity of bioactivities, namely anti-inflammatory, antimicrobial and antiviral. We have explored the synthetic access to such molecular entities, and describe now an easy and scalable approach based on reduction of the olefinic double bond of chalcone precursors via in situ hydrogenation with the system Et3SiH-Pd/C in very high yield. The intermediate chalcones were synthesized also by a simple and efficient microwave-assisted Claisen–Schmidt condensation of aromatic aldehydes with acetophenones, conveniently protected with ethoxymethyl ether, if required. Chalcones were obtained as single reaction product in high yield in 2–3 h, while under conventional conditions at room temperature the reaction was carried out with completion only after 24 h. In addition, microwave irradiation has proven very efficient for deprotection of ethoxymethyl ether with iron chloride in only 10 min and very high yield.
Elements of nurses’ professional image in electronic media and their contexts. The opinion of professionally active nurses
Authors: Sykut Anna , Massalska Klaudia , Dobrowolska Beata 
Published: June 2016

Abstract

Aim. The aim of the research was to determine the elements of a nurses’ professional image, which most frequently appear in the media and the analysis of their connotations.

Material and method. A survey was conducted on 171 women and 10 men; professionally active nurses. The study was carried out in 2015 using a questionnaire created by the author.

Results. Among the most common elements influencing the nurses’ professional image in electronic media there were strikes/protests (54.1%) and the nurses’ external appearance (40.9%). The tone of the above mentioned elements was assessed by the respondents as indifferent. According to the surveyed nurses, the most infrequently appearing professional traits were: confidence (7.7%), independence (10.5%), honesty and conscientiousness (13.3%). The overtone of these elements was evaluated as indifferent except for the ‘independence’ which was described by 36.5% of the respondents as negative. According to the respondents, the efforts to improve the image in electronic media should be done by professional organizations of nurses and midwifes and the nurses themselves. The most important task that should be undertaken by professional organizations in order to improve the overall image would be to increase wages and improve nurses’ working conditions and their identification with the professional environment.

Conclusions. The most frequently appearing elements of the professional image of nurses in the electronic media were strikes and protests. Rarely such features of nurses and the profession as self-confidence, independence and honesty and conscientiousness were mentioned. Thus there is a great need for acting towards changing the nurses’ professional image in the electronic media.
Anwendung des Reziprozitätsverfahrens zur Kalibrierung von Elektretmikrofonen
Authors: Wiesner Thomas , Thaller Kurt , Zagar Bernhard G. 
Published: June 2016

Zusammenfassung
Die Durchführung von reproduzierbaren akustischen Messungen erfordert
den Einsatz von kalibrierten Mikrofonen. Für die Kalibrierung sind,
abhängig vom Einsatzzweck, mehrere Verfahren etabliert, wobei sich mit
dem Reziprozitätsverfahren die kleinsten Unsicherheiten erreichen
lassen. Üblicherweise werden mit diesem Verfahren als Labornormal
geeignete Typen von Kondensatormikrofonen mit externer Vorspannung
kalibriert. Da beim Reziprozitätsverfahren kein Referenzmikrofon
benötigt wird, ist seine Anwendung auch bei anderen Mikrofontypen und
geringeren Unsicherheitsanforderungen interessant. Die Kalibrierung
von Elektretmikrofonen nach diesem Verfahren wurde erfolgreich
getestet. Neben den Grundlagen des Verfahrens werden der verwendete
Versuchsaufbau für die Kalibrierung sowie die Messdatenauswertung im
Detail beschrieben. Für die im Mikrofondatenblatt angegebene
Empfindlichkeit bei 1 kHz wurde eine gute Übereinstimmung mit
den Messdaten erhalten.
Scannende Infrarotdeflektometrie für die Inspektion diffus spiegelnder Oberflächen
Authors: Höfer Sebastian , Beyerer Jürgen 
Published: June 2016

Zusammenfassung
Unter Infrarotdeflektometrie versteht man die Anwendung des Messprinzips der Deflektometrie im thermischen
Infrarotspektrum. Dadurch lässt sich ausnutzen, dass vor allem raue, metallische Oberflächen in diesem Spektrum spiegelnd
erscheinen und so eine deflektometrische Inspektion ermöglicht wird. Diese Arbeit befasst sich mit dem Problem der
Erzeugung der notwendigen thermischen Codemuster und deren Auswertung. Es werden verschiedene Ansätze vorgestellt, um
Oberflächen mit Hilfe eines Industrieroboters oder im Durchlauf zu inspizieren. Darüber hinaus wird zur Auswertung der
Muster zu einer Registrierung ein neues Verfahren vorgestellt. Die Ergebnisse werden an praktisch relevanten Beispielen
demonstriert.
Regulierung von Entgelten und Gebühren in Netzwirtschaften
Authors: Gersdorf Hubertus 
Published: June 2016

Zusammenfassung
(Private und öffentliche) Monopole neigen zu Ineffizienzen. Im Rahmen des allgemeinen Kartellrechts und des sektorspezifischen Regulierungsrechts ist dafür Sorge getragen, dass solche Ineffizienzkosten auf die Verbraucher nicht übergewälzt werden können. Im vorliegenden Beitrag wird der Frage nachgegangen, ob auch das öffentlich-rechtliche Gebührenrecht einen vergleichbaren Schutzstandard gewährt. Darüber hinaus wird untersucht, ob die Vorschrift des § 130 Abs. 1 Satz 2 GWB, nach der sich die Kartellaufsicht nur auf privatrechtliche Entgelte, nicht aber auf öffentlich-rechtliche Gebühren erstreckt, von Verfassungs wegen Bestand hat.
Popular Music Celebrity Endorsements in Food and Nonalcoholic Beverage Marketing
Authors: Bragg Marie A. , Miller Alysa N. , Elizee Juleen , Dighe Shatabdi , Elbel Brian D. 
Published: June 2016

BACKGROUND:
Food and beverage marketing has been associated with childhood obesity. We quantified the number and type of food or beverage brands promoted by music celebrities, assessed the nutritional quality of the products, and examined Teen Choice Award data to assess the celebrities’ popularity among adolescents.

METHODS:
This was a descriptive study. A list of music celebrities associated with the 2013 and 2014 Billboard Hot 100 Chart, which ranks songs according to sales and radio impressions, was compiled. Data on celebrity endorsements were gathered from official company Web sites, YouTube commercials, an advertising database, and media reports. Nutritional quality of foods was assessed according to the Nutrient Profile Index, whereas nonalcoholic beverages were evaluated based on calories from added sugar. Teen Choice Award nominations were used to measure the celebrities’ popularity among adolescents.

RESULTS:
Of the 590 endorsements made by the 163 celebrities in the sample, consumer goods (eg, fragrances, makeup) represented the largest endorsement category (26%), followed by food and beverage (18%) and retail (11%). Sixty-five celebrities were collectively associated with 57 different food and beverage brands owned by 38 parent companies. Of these 65 celebrities, 53 (81.5%) had ≥1 Teen Choice Award nomination. Forty-nine (71%) of the 69 nonalcoholic beverage references promoted sugar-sweetened beverages. Twenty-one (80.8%) of the 26 endorsed foods were energy dense and nutrient poor. Baauer, will.i.am, Justin Timberlake, Maroon 5, and Britney Spears had the most food and beverage endorsements.

CONCLUSIONS:
This study demonstrates that music celebrities who are popular among adolescents endorse energy-dense, nutrient-poor products.
Febrile Seizure Risk After Vaccination in Children 6 to 23 Months
Authors: Duffy Jonathan , Weintraub Eric , Hambidge Simon J. , Jackson Lisa A. , Kharbanda Elyse O. , Klein Nicola P. , Lee Grace M. , Marcy S. Michael , Nakasato Cynthia C. , Naleway Allison , Omer Saad B. , Vellozzi Claudia , DeStefano Frank ,   on behalf of the Vaccine Safety Datalink
Published: June 2016

BACKGROUND AND OBJECTIVE:
An increased risk of febrile seizure (FS) was identified with concomitant administration of trivalent inactivated influenza vaccine (IIV3) and pneumococcal conjugate vaccine (PCV) 13-valent during the 2010–2011 influenza season. Our objective was to determine whether concomitant administration of IIV3 with other vaccines affects the FS risk.

METHODS:
We examined the risk of FS 0 to 1 day postvaccination for all routinely recommended vaccines among children aged 6 through 23 months during a period encompassing 5 influenza seasons (2006–2007 through 2010–2011). We used a population-based self-controlled risk interval analysis with a control interval of 14 to 20 days postvaccination. We used multivariable regression to control for receipt of concomitant vaccines and test for interaction between vaccines.

RESULTS:
Only PCV 7-valent had an independent FS risk (incidence rate ratio [IRR], 1.98; 95% confidence interval [CI], 1.00 to 3.91). IIV3 had no independent risk (IRR, 0.46; 95% CI, 0.21 to 1.02), but risk was increased when IIV3 was given with either PCV (IRR, 3.50; 95% CI, 1.13 to 10.85) or a diphtheria-tetanus-acellular-pertussis (DTaP)-containing vaccine (IRR, 3.50; 95% CI, 1.52 to 8.07). The maximum estimated absolute excess risk due to concomitant administration of IIV3, PCV, and DTaP-containing vaccines compared with administration on separate days was 30 FS per 100 000 persons vaccinated.

CONCLUSIONS:
The administration of IIV3 on the same day as either PCV or a DTaP-containing vaccine was associated with a greater risk of FS than when IIV3 was given on a separate day. The absolute risk of postvaccination FS with these vaccine combinations was small.
Internal Factors within Entrepreneurs that Influence the Acceptance and Use of Social Commerce among SMEs in Malaysia
Authors: Adam Azilahwati Binti , Mat Jizat Jessnor Elmy Binti , Mohd Nor Mohd Asri Bin 
Published: June 2016

<p>Current technological advances, particularly in information and communications technology (ICT) and social media have sparked a phenomenon in the business world. The existence of social commerce (s-commerce), which is a combination of e-commerce and social media, has opened up greater opportunities for SMEs in Malaysia. The use of s-commerce as a medium for marketing and buying and selling is capable of helping SMEs to increase the sales and profitability of their businesses. However, according to studies conducted by SME Corp Malaysia, the usage of e-commerce and social media is still low. Attitude and self-efficacy are variables that are often used in studies related to entrepreneurs and their intention to accept a new business innovation or technology. Therefore, this study was undertaken to identify the internal factors within entrepreneurs, namely attitude and self-efficacy, which influence the acceptance and use of s-commerce among SMEs in Malaysia.</p><p> </p>
Effect of Situational Factors and Product on Consumer Buying Decision In Hypermart at Manado City
Authors: Mamuaya Nova Christian 
Published: June 2016

<p>This research aims at (1) understanding and analyzing the effect of situational and non situational (produc) factors, simultaneously or partially, on the consumer buying decision in hypermart at Manado City, (2) understanding and analyzing factor with dominant effect on consumer buying decision in hypermart at Manado City.</p><p>The observed situational and non situational (product) factors through Belk Theory. Sampling has been developed through accidental sampling, resulting in 60 respondents. Data have been collected by main instrument of questionnaire, 5-point Likert Scale to measure the respondents’ answer, data analysis using multiple linier regression.</p><p>Results of research indicate that situational factor and product have significant effect simultaneously or partially on consumer buying decisions in hypermart at Manado City and product assortment has dominant effect on consumer buying decision in hypermart at Manado City.</p>
Influencia de los ácidos grasos insaturados en el peso corporal y en el metabolismo de la glucosa y de los lípidos en mujeres obesas con el genotipo Pro12Pro en el gen PPAR γ 2
Authors: Fófano do Lago Márcia , Chaia Kaippert Vanessa , Lopes Souto Débora , Lopes Rosado Eliane 
Published: June 2016

Introducción: el tipo de ácido graso de la dieta presenta diferentes efectos sobre la obesidad y sus complicaciones, pero estos efectos pueden verse influenciados por los genes y sus polimorfismos, tales como los receptores activados por el proliferador de los peroxisomas isoforma γ2 (PPARγ2). Además, no está claro si el grado de insaturación de los lípidos posee diferentes efectos en el metabolismo de los lípidos y de la glucosa y, particularmente, en la pérdida de peso. Objetivos: evaluar la influencia de dietas ricas en ácidos grasos poliinsaturados (AGPI) y monoinsaturados (AGMI) en las variables antropométricas y bioquímicas en el peso corporal y el perfil glucémico y lipémico en mujeres obesas con el genotipo Pro12Pro en el gen PPARγ2. Métodos: dieciocho mujeres obesas con genotipo Pro12Pro fueron distribuidas aleatoriamente para una de las dietas, rica en AGPI (n = 8) o AGMI (n = 10). Las variables antropométricas (índice de masa corporal [IMC] y circunferencia de la cintura) y bioquímicas (glucosa, insulina, HOMA-IR, colesterol total, LDL-colesterol, HDL colesterol y triglicéridos) fueron evaluadas antes y después de un periodo de 45 días. Resultados: las variables antropométricas y bioquímicas fueron similares entre los grupos antes y después de la intervención (p > 0,05). El IMC disminuyó después de la ingesta de AGPI (p = 0,01), probablemente debido al menor contenido de lípidos. El AGMI redujo la glucosa (p = 0,03), insulina (p = 0,03) y HOMA-IR (p = 0,02). Conclusión: los AGMI fueron más eficientes para reducir la resistencia a la insulina en mujeres obesas con el genotipo Pro12Pro en el gen PPARγ2, aunque las mujeres presentaran una elevada ingesta de lípidos totales y ácidos grasos saturados.
Relación entre condición física, actividad física y diferentes parámetros antropométricos en escolares de Santiago (Chile)
Authors: Muros José Joaquín , Cofre-Bolados Cristian , Zurita-Ortega Félix , Castro-Sánchez Manuel , Linares-Manrique Marta , Chacón-Cuberos Ramón 
Published: June 2016

Introducción: la sociedad actual está experimentando reducciones significativas en los niveles de actividad física, y estos niveles de sedentarismo están asociados a un aumento de la obesidad. Objetivo: describir y analizar las relaciones entre composición corporal, realización de actividad física y condición física, además de describir los índices de sobrepeso/obesidad de una muestra de escolares de la provincia de Santiago (Chile). Material y métodos: se diseñó un estudio transversal con una muestra representativa de 515 alumnos (10,6 ± 0,5). Se determinaron diferentes índices antropométricos (IMC y porcentaje graso), así como la actividad física y la condición física (capacidad aeróbica y fuerza muscular máxima en tren superior e inferior). Resultados: alrededor del 55% de la muestra estudiada presentó problemas de sobrepeso/obesidad. Los valores de volumen de oxígeno máximo (VO 2 máx) y fuerza del tren superior fueron estadísticamente superiores en el grupo de los niños que en el de las niñas. Los alumnos clasificados como obesos presentaron unos niveles superiores de porcentaje graso, así como unos niveles inferiores de actividad física y de condición física que el grupo con normopeso. Se encontró una correlación negativa entre las puntuaciones del PAQ-C (Physical Activity Questionnaire for Older Children) y los parámetros antropométricos, así como entre los parámetros antropométricos y los valores obtenidos en todas las pruebas de condición física. Conclusión: ante los alarmantes niveles de sobrepeso y obesidad infantil detectados en Santiago parece de importante relevancia crear planes de intervención centrados en la mejora de la condición física; los grupos con problemas de sobrepeso y obesidad y los grupos de sexo femeninos donde se debería hacer una mayor incidencia.