bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical correction of hallux valgus complicated with adult-type pes plano-valgus
Authors: Choi Jun Young , Yoon Hyeong Hwa , Suh Yu Min , Suh Jin Soo 
Published: February 2017

Purpose: To investigate the efficiency of simultaneous correction of moderate to severe hallux valgus deformity and adult-type pes planus. Methods: Twenty cases of moderate to severe hallux valgus complicated with adult-type pes planus in 19 consecutive patients (15 (79%) women, 4 (11%) men; mean age: 44.50 ± 17.13 years, mean follow-up duration: 31.30 ± 17.02 months) were included. Medial calcaneal sliding osteotomy was performed to correct hindfoot valgus, whereas treatments of hallux valgus were case dependent. Results: The mean postoperative hallux valgus angle, intermetatarsal angle, hindfoot alignment angle, and hindfoot alignment ratio were 8.40 ± 5.29°, 4.20 ± 2.54°, 3.09 ± 2.92º and 0.41 ± 0.17, respectively. Although a hallux varus deformity occurred as a postoperative complication in one case (5%), there were no cases of postoperative recurrence. Conclusion: Simultaneous correction of hallux valgus and pes plano-valgus using medial calcaneal sliding osteotomy is an effective technique that reduces recurrence of hallux valgus and increases satisfaction in patients with moderate to severe hallux valgus deformity complicated with adult-type pes planus accompanying hindfoot valgus.
C5 nerve root palsy after posterior cervical spine surgery
Authors: Pan Fu-Min , Wang Shan-Jin , Ma Bin , Wu De-Sheng 
Published: February 2017

Background: C5 palsy is a serious complication after cervical decompression surgery in which the patient shows a deterioration in power of the deltoid or biceps brachii by at least one grade in the manual muscle test without aggravation of lower extremity function. Although there are several hypotheses regarding the etiology of C5 palsy, the pathogenesis and preventive measures remain unidentified and many other controversies remain. Objective: To systematically review the clinical features, risk factors, mechanism, and preventive measures of C5 palsy after posterior cervical decompression surgery. Materials and methods: PubMed was searched to identify eligible studies that contained more than 10 cases and focused on C5 palsy. Microsoft Excel was used to analyze the data. Statistical comparisons were made when appropriate. Results: Out of 718 papers involving C5 palsy, 28 met the inclusion criteria. The average incidence rate was 7.8% (range, 1.4–23.0%). Risk factors for C5 palsy included age, male gender, ossification of the posterior longitudinal ligament, and stenosis of the C4–C5 intervertebral foramen. C5 palsy occurred from immediately to 2 months after surgery, and recovery time ranged from 48 h to 41 months. Hypotheses for the mechanism of C5 palsy included root involvement and spinal cord impairment. Foraminotomy and intraoperative neuromonitoring were the two main methods used to prevent C5 palsy. Conclusion: C5 palsy is a serious complication occurring at the early stage after cervical decompression surgery. Foraminotomy and intraoperative neuromonitoring were the two main methods to prevent C5 palsy. The incidence of C5 palsy is low, but it can place a serious burden on the patients’ quality of life and finances. The risk factors and mechanism of C5 palsy are still controversial. However, under conservative therapy, the prognosis is usually good. Higher quality studies are necessary for drawing more reliable and convincing conclusions about this disease.
Role of RUNX1 in hematological malignancies
Authors: Sood Raman , Kamikubo Yasuhiko , Liu Paul 
Published: February 2017

Abstract
RUNX1 is a member of the core-binding factor family of transcription factors and is indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is one of the most frequently mutated genes in a variety of hematological malignancies. Germ line mutations in RUNX1 cause familial platelet disorder with associated myeloid malignancies. Somatic mutations and chromosomal rearrangements involving RUNX1 are frequently observed in myelodysplastic syndrome and leukemias of myeloid and lymphoid lineages, that is, acute myeloid leukemia, acute lymphoblastic leukemia, and chronic myelomonocytic leukemia. More recent studies suggest that the wild-type RUNX1 is required for growth and survival of certain types of leukemia cells. The purpose of this review is to discuss the current status of our understanding about the role of RUNX1 in hematological malignancies.
Long-term outcome and safety of prolonged bedaquiline treatment for multidrug-resistant tuberculosis
Authors: Guglielmetti Lorenzo , Jaspard Marie , Le Dû Damien , Lachâtre Marie , Marigot-Outtandy Dhiba , Bernard Christine , Veziris Nicolas , Robert Jérôme , Yazdanpanah Yazdan , Caumes Eric , Fréchet-Jachym Mathilde 
Published: February 2017

Bedaquiline, a recently approved drug for the treatment of multidrug-resistant tuberculosis (MDR-TB), is recommended for a duration of 24 weeks. There are scarce data on patients treated with this drug outside clinical trials.All MDR-TB patients who started treatment from January 1, 2011 to December 31, 2013 and received ≥30 days of bedaquiline were included in a multicentre observational cohort.Among 45 MDR-TB patients, 53% harboured isolates resistant to both fluoroquinolones and second-line injectables, and 38% harboured isolates resistant to one of these drug classes. Median bedaquiline treatment duration was 361 days and 33 patients (73%) received prolonged (>190 days) bedaquiline treatment. Overall, 36 patients (80%) had favourable outcome, five were lost to follow-up, three died, and one failed and acquired bedaquiline resistance. No cases of recurrence were reported. Severe and serious adverse events were recorded in 60% and 18% of patients, respectively. Values of Fridericia-corrected QT interval (QTcF) >500 ms were recorded in 11% of patients, but neither arrhythmias nor symptomatic cardiac side-effects occurred. Bedaquiline was discontinued in three patients following QTcF prolongation. No significant differences in outcomes or adverse events rates were observed between patients receiving standard and prolonged bedaquiline treatment.Bedaquiline-containing regimens achieved favourable outcomes in a large proportion of patients. Prolonged bedaquiline treatment was overall well tolerated in this cohort.
Prior host-country work experience and immigrant labor market outcomes: evidence from Canada
Authors: Pandey Manish , Townsend James 
Published: February 2017

Abstract
Recent changes to immigration selection policies favor skilled workers with prior work experience in the immigrant host country. Using unique administrative tax data for Canada, we estimate earnings equations to quantify the difference in earnings of immigrants with prior Canadian experience (prefilers) and those without prior experience (non-prefilers). We find that, relative to non-prefilers, entry earnings are higher for prefilers and, for male immigrants, this earnings advantage persists for at least 20 years after arrival. We show that the primary source of the higher entry earnings of prefilers is a higher return to foreign experience. In addition, the prefiler earnings advantage is largest for university graduates and the return to foreign experience is higher for prefilers from Western countries than those from the rest of the world. Our findings suggest that a move towards an immigrant selection system which uses previous host-country work experience as a criterion will improve the labor market performance of immigrants.
Treatment of chronic ulcers
Authors: Aschermann I. , Mnich Ch.D. , Busch Ch. 
Published: February 2017

SummaryChronic ulcers (CUs) are a major cause of morbidity and mortality with increasing prevalence, in part due to the ageing population, and an increase of risk factors such as diabetes and obesity. CUs are caused by numerous diseases including venous dysfunction, diabetes mellitus, infections, peripheral neuropathy, pressure, and atherosclerosis. The current standard therapy for CUs includes compression, surgical débridement, infection control, and adequate wound dressings. As a high percentage of CUs do not adequately heal or quickly relapse with standard treatments, additional therapeutic approaches are pursued, termed “advanced wound care therapies”. Here, an overview on commonly applied therapies lacking significant evidence for wound healing is reviewed, followed by therapies with significant evidence supporting the routine use in the treatment of CUs, and a short outlook in a possible future wound treatment landscape.To give a résumé, the presented literature reveals that most of the commonly applied topical and advanced ulcer treatments largely lack solid scientific evidence for the induction or acceleration of wound healing. Surprisingly only “classical” treatments such as wound cleansing, débridement and compression have significant evidence. Novel approaches such as bilayered skin reconstructs, cell suspensions or extracorporal shock waves seem promising. Considering the increasing number of ulcer patients, there is a strong need for further basic research to fully understand all factors involved in wound development and healing of the various ulcer pathophysiologies, and the urgent need for prospective clinical trials comparing the various treatment options.
Large vein reconstructions in the endovascular era
Authors: Gloviczki P. 
Published: February 2017

SummaryMax Ratschow was a remarkable physician and an international authority in the field of angiology and the Ratschow lectureship helps to fulfill this pioneer’s life purpose: to advance evaluation and treatment of vascular diseases. The 2017 Max Ratschow lecture covers some recent advances and controversies in venous diseases. Phlebology, once a neglected field of angiology, is a discipline that has been in constant progress during the past decades. Endovascular techniques revolutionized treatment of patients with large vein obstruction and provided safe, minimally invasive procedures with excellent long term results. Attention now need to focus on comparative studies to provide scientific evidence of efficacy of venous angioplasty and stenting with properly organized randomized controlled trials. Further attempts are needed to develop special venous stents and to decrease thrombotic complications and formation of pseudointima that cause in-stent restenosis. Open and hybrid reconstructions are safe and durable, but the number of procedures in general is small and special training and expertise for reconstructive venous surgery is recommended. Autologous vein should be used for infrainguinal reconstructions and for treatment of unilateral iliac vein obstruction with a femoro-femoral cross-over bypass (Palma procedure). IVC and iliac vein reconstructions with ePTFE grafts provide superb result in patients who need excision of malignant tumors invading large veins. Open and hybrid reconstructions are here to stay and they remain excellent options for those patients who are unsuitable for or fail endovascular repair.
Asset Pricing with Spatial Interaction
Authors: Kou Steven , Peng Xianhua , Zhong Haowen 
Published: February 2017

We propose a spatial capital asset pricing model and a spatial arbitrage pricing theory (S-APT) that extend the classical asset pricing models by incorporating spatial interaction. We then apply the S-APT to study the comovements of eurozone stock indices (by extending the Fama–French factor model to regional stock indices) and the futures contracts on S&P/Case–Shiller Home Price Indices; in both cases, spatial interaction is significant and plays an important role in explaining cross-sectional correlation.The e-companion is available at https://doi.org/10.1287/mnsc.2016.2627 .This paper was accepted by Neng Wang, finance.
A Model of Product Design and Information Disclosure Investments
Authors: Markopoulos Panos M. , Hosanagar Kartik 
Published: February 2017

New technologies such as product simulators and virtual reality now allow firms to provide realistic product usage experiences and reduce buyer uncertainty about product quality. We argue that today’s firms should view product design and investments to reduce buyer uncertainty as an integrated process, which is in turn influenced by how much information buyers can obtain from third-party infomediaries. We introduce a game-theoretic model of a competitive market where both quality production and quality disclosure are endogenous decisions, affected by information made available by third parties. We show that quality investment under uncertainty never exceeds the level of quality investment under perfect information. Furthermore, we show that information availability by third parties allows firms to free ride, and it especially favors lower quality firms, who can reduce their information disclosure investments more so than higher-quality firms. Finally, we show that the intuitive argument that firms must improve their product quality when overall information availability in the market improves does not always hold. Instead, improved information availability may enable firms to reduce their quality in some situations. The online appendix is available at https://doi.org/10.1287/mnsc.2016.2634 . This paper was accepted by Chris Forman, information systems.
Mutual and Exclusive: Dyadic Sources of Trust in Interorganizational Exchange
Authors: McEvily Bill , Zaheer Akbar , Kamal Darcy K. Fudge 
Published: February 2017

Trust in interfirm exchange has traditionally been treated as mutually held and jointly determined by the two parties in a relationship. Yet, the expectations of exchange partners can, and routinely do, differ with respect to the goals, preferences, and vulnerabilities in their shared relationship. To account for such differences in expectations, we propose a broadened conceptualization of the sources of interorganizational trust as dyadic. Viewing the sources of trust as dyadic expands the conventional focus on mutual elements to further emphasize exclusive features of an exchange relationship. To substantiate our theory, we examine a key source of interorganizational trust, exchange hazards, and assess the extent to which its effects vary as a function of (1) the locus of exchange hazards (own versus other) in the dyad, (2) the degree of power imbalance in the dyad, and (3) each party’s power position in the dyad. To assess the validity of our claims, we devise a matched dyad research design and collect identical information from both buyers and suppliers in a given exchange relationship. Based on our results, we make three unique observations consistent with the notion of dyadic sources of trust. First, the same exchange hazards have contrasting effects on trust (enhancing versus diminishing) across the dyad. Second, the degree of power imbalance has opposing effects across the dyad. Third, the relative significance of partners’ exchange hazards varies based on their respective power positions. The online appendix is available at https://doi.org/10.1287/orsc.2016.1102
Teaching a creativity-based skill through self-pacing
Authors: Dobolyi Kinga , Amman Paul , Kauffman Chris , Lester Jamie , Praphamontripong Upsorn , Rangwala Huzefa , Setia Sanjeev , Wang Pearl 
Published: February 2017

Learning a creativity-based skill like programming requires practice and dedication. In “traditional” programming courses, instructors spend most of their time lecturing to large groups of students, with little class time to spend on active exercises or personal interaction. Students are not in control of the content delivery or its pacing, nor is it effectively communicated that practice is needed to master programming. Moreover, most practice is individual and graded strictly, meaning students suffer heavy penalties for minor slips while learning or collaborating. This past year we experimented with a self-paced version of introductory programming, where students spend class time working on problems in small groups at their own pace. Learning is intentional because students take responsibility for their learning, rather than waiting for the instructor. Our pass rates in the course improved by 25% with these modifications. This design could be adapted to other disciplines. We propose to demonstrate our innovations by leading the audience in a simulation of our self-paced, active learning, class by teaching the 'students' to solve a simple puzzle. Members of our instructional team will play the role of teaching assistants, who offer peer learning opportunities in our classrooms. Like students, the audience will have varying levels of previous exposure to these puzzles, so they will move through the exercises at their own pace. We will demonstrate how faculty can use immediate automated feedback, asynchronous online content, individual assessments with the ability to test up to five times, interventions, peer-learning, and mini-lectures to allow students to learn new skills at their own pace. Suggestions for adapting this to other disciplines will also be discussed.
Deep eutectic solvents as versatile media for the synthesis of noble metal nanomaterials
Authors: Lee Jae-Seung 
Published: February 2017

AbstractDeep eutectic solvents (DESs) were developed 15 years ago and have been used for various purposes based on their unique chemical and physical properties. Recently, they have been highlighted as versatile media for the synthesis of noble metal nanomaterials. Although there are a few limitations, their vast chemical library of hydrogen bond donors and excellent solubility show great potential for their future applications for the synthesis of noble metal nanoparticles.
HUBUNGAN PANJANG- BERAT, KEBIASAANMAKAN DAN KEMATANGANGONAD IKAN BILIH (Mystaecoleucus padangensis) DI DANAUTOBA, SUMATERAUTARA
Authors: Umar Chairulwan , Kartamihardja Endi Setiadi 
Published: February 2017

Ikan bilih (Mystacoleucus padangensis Bleeker) diDanau Toba adalah jenis ikan introduksi dari Danau Singkarak, Sumatera Barat. Pada saat ini terdapat kecenderungan ukuran individu menurun, hal ini antara lain disebabkan oleh penangkapan yang intensif menggunakan alat tangkap bagan apung dengan ukuran mata jaring relatif kecil (< 1,25 inci). Penelitian ini bertujuan untuk melihat beberapa aspek biologi meliputi ukuran panjang dan bobot, kebiasaan makan, tingkat kematangan gonad dan fekunditasnya. Hasil penelitian diperoleh hubungan panjang dan bobot individu bersifat allometrik positif dengan panjang total rata-rata 12,6 cmdan bobot rata-rata 19,8 g/ekor. Dari analisa lambung ikan bilih pemakan detritus (78,2 – 92,9 %), fitoplankton dan zooplankton sebagai pakan tambahan (4,9 – 11,5 %) serta seresah tumbuhan sebagai pakan pelengkap (1,9 – 1,8 %). Hasil pengamatan ikan bilih yang matang gonaddiperoleh nilai fekunditasnya rata-rata berkisar antara 5.262 – 16.117 butir telur. Hasil pengamatan TKG dan jumlah telur menunjukkan ikan bilih dapat bertelur danmemijah sepanjang tahun dan berkembang dengan baik sehingga ikan ini tetap lestari walaupun adanya eksploitasi yang cukup intensif. Bilih (Mystacoleucus padangensis Bleeker) in Toba Lake was introduce from Singkarak Lake,West Sumatra. At present the growth was decreased, it caused by intensive fishing and the uses of lift net with small mesh size (under 1,25 inch). This research aims to know some biological aspects of bilih such as length - weight, relationship food habit, level of gonadal maturity, and fecundity. The results showed that growth pattern of bilih positive allometric with average length of about 12,6 cm and average weight of about 19,8 gr/each. Bilih detritus feeding (78,2 – 92,9%), phytoplankton and zooplankton as additional food (4,9 – 11,5%) and seresah tumbuhan as complement food (1,9 – 1,8%). Fecundity of ranged from 5.262 – 16.117. TKG observation and eggs gain showed that bilih could development and spawn in long years and growth well enough, so that bilih can stlll growth rapidly eventhough there is an exploitation.
DISTRIBUSI SPASIALDANTEMPORALPLANKTON DI PERAIRANTELUKTOMINI, SULAWESI
Authors: Setyadji Bram , Priatna Asep 
Published: February 2017

Planktonmerupakan komponen penting dalamkehidupan akuatik karena fungsi biologisnya yang penting sebagaimata rantai paling dasar dalam rantai makanan dan merupakan organisme yang menduduki kunci utama di dalam ekosistem bahari. Penelitian ini dilakukan pada bulanMei, Juli, dan Nopember 2010 yangmewakili musimperalihan I, musim timur dan musim barat dengan tujuan mengetahui distribusi kelimpahan spasial dan temporal fitoplankton dan zooplankton di Teluk Tomini. Kelimpahan fitoplankton dan zooplankton tertinggi terdapat pada musim barat sebesar 177.666 sel/m3 dan 7.088 ind/m3, sedangkan terendah pada musim timur sebesar 4.878 sel/m3 dan 1.118 ind/ m3. Tingkat indek keaneka-ragaman (H) baik fitoplankton dan zooplankton sedang, indek keseragaman (E) rendah hingga sedang, dan tidak ditemukan jenis tertentu yang dominan. Chaetoceros, Coscinodiscus, dan Rhizosolenia dari kelas Bacillariophyceae merupakan fitoplankton yangmempunyai frekuensi kehadiran yang tinggi, sedangkan Crustaceae merupakan zooplankton yang dominan. Konsentrasi sebaran terdapat dimulut teluk dan tersebar relatif sesuai dengan musim. Plankton plays important role in aquatic life due to its significant biological function as basic food chain in oceanic ecosystem. This studywas conducted on May, July, and November representing north-west monsoon, east monsoon, and west monsoon, respectively. The purposed of this study is to know the spatial and temporal distribution and the abundance of phytoplankton and zooplankton in Tomini Bay. Results showed that the highest abundance of phytoplankton and zooplankton were 177.667 cell/m3 and 7.088 ind/m3 that appeared at north-west monsoon, while the lowest were 4.878 cell/m3 and 1.118 ind/m3 that shown in south-east monsoon. The diversity index (H) for both Phytoplankton and Zooplankton were in medium (1<H<3), while the eveness index (E) range from low (d”1) to medium. There were no dominance species found. However, Chaetoceros, Coscinodiscus and Rhizosolenia that representing Bacillariophyceae showed a high frequency of appearance, while Crustaceae group were the dominance of zooplankton. The distribution of plankton concentrated in the mouth of the bay and relatively distributed according to seasons.