bluuebunny/crossref_metadata_2025_split huggingface dataset:
Narrative production in monolingual and bilingual children with specific language impairment
Authors: TSIMPLI IANTHI MARIA , PERISTERI ELENI , ANDREOU MARIA 
Published: December 2015

ABSTRACTThe aim of this study was to identify potential clinical markers of specific language impairment (SLI) in bilingual children with SLI by using the Greek version of the Multilingual Assessment Instrument for Narratives. Twenty-one Greek-speaking monolingual and 15 bilingual children with SLI participated, along with monolingual (N = 21) and bilingual (N = 15) age-matched children with typical development. Results showed differences between typically development children and children with SLI in microstructure, while bilingual children with SLI were found to attain similar levels of performance, and even to outperform monolingual children with SLI, in macrostructure. It is suggested that the retelling coding scheme could permit differential diagnosis of SLI among bilingual children within the scope of narrative assessment.
The moderating role of parenting on the relationship between psychopathy and antisocial behavior in adolescence
Authors: Silva Teresa C. , Stattin Håkan 
Published: December 2015

AbstractWe aimed to analyze the impact of several parenting factors on the relationship between psychopathy and antisocial behavior. Nine hundred youths and their mothers reported on parent–youth interactions, and youth self-report measures of psychopathy, delinquency and violent behavior were taken. Multiple regression was used to test for the significance of interactions between parenting and psychopathy scores. In terms of delinquency, linear interactions between psychopathy and the level of conflict with parents and parents' knowledge of their youths' whereabouts/youths' willingness to disclose information were found based on the data reported by the youths. Data reported by mothers indicated a linear interaction between psychopathy and parents' knowledge/youth disclosure, and a quadratic interaction of conflict with parents. For violence, we used logistic regression models to analyze moderation. No interaction effects between psychopahy scores and parenting factors were found. Youths' reports of high conflict with parents and parents' knowledge/youth disclosure showed to have an impact on violence regardless of the level of psychopathic traits. Implications for the prevention and treatment are discussed.
Apoptotic cell clearance of Leishmania major-infected neutrophils by dendritic cells inhibits CD8+ T-cell priming in vitro by Mer tyrosine kinase-dependent signaling
Authors: Ribeiro-Gomes F L , Romano A , Lee S , Roffê E , Peters N C , Debrabant A , Sacks D 
Published: December 2015

AbstractNeutrophils are the predominant recruited and infected cells during the early stages of Leishmania major infection in the skin, and depletion of neutrophils promotes immunity to infection transmitted by sand fly bite. In order to better understand how the acute neutrophilic response suppresses immunity, we assessed the consequences of the interaction between neutrophils recovered from the skin-inoculation site and bone marrow-derived dendritic cells (DCs) in vitro. The capture of infected, apoptotic neutrophils by the DCs completely inhibited their cross-presentation function that was dependent on engagement of the receptor tyrosine kinase Mer on the DCs. The capture of uninfected neutrophils, or neutrophils infected with Toxoplasma gondii, had only slight immunomodulatory effects. These studies define the clearance of infected, apoptotic neutrophils by DCs and Mer receptor signaling as central to the early immune evasion strategies of L. major, with relevance to other vector-borne pathogens delivered by bite to the skin.
A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance
Authors: Ageta-Ishihara Natsumi , Yamazaki Maya , Konno Kohtarou , Nakayama Hisako , Abe Manabu , Hashimoto Kenji , Nishioka Tomoki , Kaibuchi Kozo , Hattori Satoko , Miyakawa Tsuyoshi , Tanaka Kohichi , Huda Fathul , Hirai Hirokazu , Hashimoto Kouichi , Watanabe Masahiko , Sakimura Kenji , Kinoshita Makoto 
Published: December 2015

AbstractThe small GTPase-effector proteins CDC42EP1-5/BORG1–5 interact reciprocally with CDC42 or the septin cytoskeleton. Here we show that, in the cerebellum, CDC42EP4 is exclusively expressed in Bergmann glia and localizes beneath specific membrane domains enwrapping dendritic spines of Purkinje cells. CDC42EP4 forms complexes with septin hetero-oligomers, which interact with a subset of glutamate transporter GLAST/EAAT1. In Cdc42ep4−/− mice, GLAST is dissociated from septins and is delocalized away from the parallel fibre-Purkinje cell synapses. The excitatory postsynaptic current exhibits a protracted decay time constant, reduced sensitivity to a competitive inhibitor of the AMPA-type glutamate receptors (γDGG) and excessive baseline inward current in response to a subthreshold dose of a nonselective inhibitor of the glutamate transporters/EAAT1–5 (DL-TBOA). Insufficient glutamate-buffering/clearance capacity in these mice manifests as motor coordination/learning defects, which are aggravated with subthreshold DL-TBOA. We propose that the CDC42EP4/septin-based glial scaffold facilitates perisynaptic localization of GLAST and optimizes the efficiency of glutamate-buffering and clearance.
Humidity trends imply increased sensitivity to clouds in a warming Arctic
Authors: Cox Christopher J. , Walden Von P. , Rowe Penny M. , Shupe Matthew D. 
Published: December 2015

AbstractInfrared radiative processes are implicated in Arctic warming and sea-ice decline. The infrared cloud radiative effect (CRE) at the surface is modulated by cloud properties; however, CRE also depends on humidity because clouds emit at wavelengths that are semi-transparent to greenhouse gases, most notably water vapour. Here we show how temperature and humidity control CRE through competing influences between the mid- and far-infrared. At constant relative humidity, CRE does not decrease with increasing temperature/absolute humidity as expected, but rather is found to be approximately constant for temperatures characteristic of the Arctic. This stability is disrupted if relative humidity varies. Our findings explain observed seasonal and regional variability in Arctic CRE of order 10 W m−2. With the physical properties of Arctic clouds held constant, we calculate recent increases in CRE of 1–5 W m−2 in autumn and winter, which are projected to reach 5–15 W m−2 by 2050, implying increased sensitivity of the surface to clouds.
Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels
Authors: Rama Sylvain , Zbili Mickaël , Bialowas Andrzej , Fronzaroli-Molinieres Laure , Ankri Norbert , Carlier Edmond , Marra Vincenzo , Debanne Dominique 
Published: December 2015

AbstractIn the mammalian brain, synaptic transmission usually depends on presynaptic action potentials (APs) in an all-or-none (or digital) manner. Recent studies suggest, however, that subthreshold depolarization in the presynaptic cell facilitates spike-evoked transmission, thus creating an analogue modulation of a digital process (or analogue–digital (AD) modulation). At most synapses, this process is slow and not ideally suited for the fast dynamics of neural networks. We show here that transmission at CA3–CA3 and L5–L5 synapses can be enhanced by brief presynaptic hyperpolarization such as an inhibitory postsynaptic potential (IPSP). Using dual soma–axon patch recordings and live imaging, we find that this hyperpolarization-induced AD facilitation (h-ADF) is due to the recovery from inactivation of Nav channels controlling AP amplitude in the axon. Incorporated in a network model, h-ADF promotes both pyramidal cell synchrony and gamma oscillations. In conclusion, cortical excitatory synapses in local circuits display hyperpolarization-induced facilitation of spike-evoked synaptic transmission that promotes network synchrony.
Multitrophic diversity in a biodiverse forest is highly nonlinear across spatial scales
Authors: Schuldt Andreas , Wubet Tesfaye , Buscot François , Staab Michael , Assmann Thorsten , Böhnke-Kammerlander Martin , Both Sabine , Erfmeier Alexandra , Klein Alexandra-Maria , Ma Keping , Pietsch Katherina , Schultze Sabrina , Wirth Christian , Zhang Jiayong , Zumstein Pascale , Bruelheide Helge 
Published: December 2015

AbstractSubtropical and tropical forests are biodiversity hotspots, and untangling the spatial scaling of their diversity is fundamental for understanding global species richness and conserving biodiversity essential to human well-being. However, scale-dependent diversity distributions among coexisting taxa remain poorly understood for heterogeneous environments in biodiverse regions. We show that diversity relations among 43 taxa—including plants, arthropods and microorganisms—in a mountainous subtropical forest are highly nonlinear across spatial scales. Taxon-specific differences in β-diversity cause under- or overestimation of overall diversity by up to 50% when using surrogate taxa such as plants. Similar relationships may apply to half of all (sub)tropical forests—including major biodiversity hotspots—where high environmental heterogeneity causes high biodiversity and species turnover. Our study highlights that our general understanding of biodiversity patterns has to be improved—and that much larger areas will be required than in better-studied lowland forests—to reliably estimate biodiversity distributions and devise conservation strategies for the world’s biodiverse regions.
A mirrorless spinwave resonator
Authors: Pinel Olivier , Everett Jesse L. , Hosseini Mahdi , Campbell Geoff T. , Buchler Ben C. , Lam Ping Koy 
Published: December 2015

AbstractOptical resonance is central to a wide range of optical devices and techniques. In an optical cavity, the round-trip length and mirror reflectivity can be chosen to optimize the circulating optical power, linewidth and free-spectral range (FSR) for a given application. In this paper we show how an atomic spinwave system, with no physical mirrors, can behave in a manner that is analogous to an optical cavity. We demonstrate this similarity by characterising the build-up and decay of the resonance in the time domain and measuring the effective optical linewidth and FSR in the frequency domain. Our spinwave is generated in a 20 cm long Rb gas cell, yet it facilitates an effective FSR of 83 kHz, which would require a round-trip path of 3.6 km in a free-space optical cavity. Furthermore, the spinwave coupling is controllable enabling dynamic tuning of the effective cavity parameters.
Polymorphisms of BCL2 and BAX Genes Associate with Outcomes in Advanced Non-small cell lung cancer Patients treated with platinum-based Chemotherapy
Authors: Peng Yu , Wang Linang , Qing Yi , Li Chongyi , Ren Tao , Li Qing , Li Mengxia , Zhang Shiheng , Shan Jinglu , Wang Ge , Yang Zhenzhou , Wang Dong 
Published: December 2015

AbstractSingle-nucleotide polymorphisms (SNP) of the gene belonging to the BCL2 family are thought to play a role in chemotherapy resistance. This study investigated the association of BCL2-938C>A(rs2279115) and BAX-248G>A(rs4645878) promoter region SNPs and the clinical responses and outcomes of 235 non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy. The data suggested that BAX-248GA and GA+AA genotype was associated with poor response [odds ratio (OR) 1.943, p = 0.039; OR 1.867, p = 0.038, respectively] to chemotherapy and BCL2-938CA, CA+AA and BAX-248GA, AA and GA+AA were associated with poor progression-free survival (PFS) [hazard ratio (HR) 1.514, p = 0.004; HR 1.456, p = 0.009; HR 1.449, p = 0.013; HR 2.006, p = 0.010; HR 1.506, p = 0.003, respectively] and BCL2-938CA, AA and CA+AA and BAX-248GA, AA and GA+AA were associated with poor overall survival (OS) (HR 2.006, p < 0.001; HR 2.322, p < 0.001; HR 2.096, p < 0.001; HR 1.632, p = 0.001; HR 2.014, p = 0.010; HR 1.506, p < 0.001, respectively). Furthermore, combination of these two polymorphisms showed patients with 2–4 variant alleles of these two genes associated with poor PFS and OS (HR 1.637, p = 0.001; HR 2.365, p < 0.001). The data from the current study provide evidence that BCL2-938C>A and BAX-248G>A polymorphisms may be useful in predicting clinical outcomes of patients with advanced inoperable NSCLC to platinum-based chemotherapy.
PTEN stabilizes TOP2A and regulates the DNA decatenation
Authors: Kang Xi , Song Chang , Du Xiao , Zhang Cong , Liu Yu , Liang Ling , He Jinxue , Lamb Kristy , Shen Wen H. , Yin Yuxin 
Published: December 2015

AbstractPTEN is a powerful tumor suppressor that antagonizes the cytoplasmic PI3K-AKT pathway and suppresses cellular proliferation. PTEN also plays a role in the maintenance of genomic stability in the nucleus. Here we report that PTEN facilitates DNA decatenation and controls a decatenation checkpoint. Catenations of DNA formed during replication are decatenated by DNA topoisomerase II (TOP2) and this process is actively monitored by a decatenation checkpoint in G2 phase. We found that PTEN deficient cells form ultra-fine bridges (UFBs) during anaphase and these bridges are generated as a result of insufficient decatenation. We show that PTEN is physically associated with a decatenation enzyme TOP2A and that PTEN influences its stability through OTUD3 deubiquitinase. In the presence of PTEN, ubiquitination of TOP2A is inhibited by OTUD3. Deletion or deficiency of PTEN leads to down regulation of TOP2A, dysfunction of the decatenation checkpoint and incomplete DNA decatenation in G2 and M phases. We propose that PTEN controls DNA decatenation to maintain genomic stability and integrity.
Antagonism of Nav channels and α1-adrenergic receptors contributes to vascular smooth muscle effects of ranolazine
Authors: Virsolvy Anne , Farah Charlotte , Pertuit Nolwenn , Kong Lingyan , Lacampagne Alain , Reboul Cyril , Aimond Franck , Richard Sylvain 
Published: December 2015

AbstractRanolazine is a recently developed drug used for the treatment of patients with chronic stable angina. It is a selective inhibitor of the persistent cardiac Na+ current (INa) and is known to reduce the Na+-dependent Ca2+ overload that occurs in cardiomyocytes during ischemia. Vascular effects of ranolazine, such as vasorelaxation,have been reported and may involve multiple pathways. As voltage-gated Na+ channels (Nav) present in arteries play a role in contraction, we hypothesized that ranolazine could target these channels. We studied the effects of ranolazine in vitro on cultured aortic smooth muscle cells (SMC) and ex vivo on rat aortas in conditions known to specifically activate or promote INa. We observed that in the presence of the Nav channel agonist veratridine, ranolazine inhibited INa and intracellular Ca2+ calcium increase in SMC and arterial vasoconstriction. In arterial SMC, ranolazine inhibited the activity of tetrodotoxin-sensitive voltage-gated Nav channels and thus antagonized contraction promoted by low KCl depolarization. Furthermore, the vasorelaxant effects of ranolazine, also observed in human arteries and independent of the endothelium, involved antagonization of the α1-adrenergic receptor. Combined α1-adrenergic antagonization and inhibition of SMCs Nav channels could be involved in the vascular effects of ranolazine.
RETRACTED ARTICLE: Acupuncture elicits neuroprotective effect by inhibiting NAPDH oxidase-mediated reactive oxygen species production in cerebral ischaemia
Authors: Shi Guang-Xia , Wang Xue-Rui , Yan Chao-Qun , He Tian , Yang Jing-Wen , Zeng Xiang-Hong , Xu Qian , Zhu Wen , Du Si-Qi , Liu Cun-Zhi 
Published: December 2015

AbstractIn the current study, we aimed to investigate whether NADPH oxidase, a major ROS-producing enzyme, was involved in the antioxidant effect of acupuncture on cognitive impairment after cerebral ischaemia. The cognitive function, infract size, neuron cell loss, level of superoxide anion and expression of NADPH oxidase subunit in hippocampus of two-vessel occlusion (2VO) rats were determined after 2-week acupuncture. Furthermore, the cognitive function and production of O2− were determined in the presence and absence of NADPH oxidase agonist (TBCA) and antagonist (Apocynin). The effect of acupuncture on cognitive function after cerebral ischaemia in gp91phox-KO mice was evaluated by Morris water maze. Acupuncture reduced infarct size, attenuated overproduction of O2− and reversed consequential cognitive impairment and neuron cell loss in 2VO rats. The elevations of gp91phox and p47phox after 2VO were significantly decreased after acupuncture treatment. However, no differences of gp91phox mRNA were found among any experimental groups. Furthermore, these beneficial effects were reversed by TBCA, whereas apocynin mimicked the effect of acupuncture by improving cognitive function and decreasing O2− generation. Acupuncture failed to improve the memory impairment in gp91phox KO mice. Full function of the NADPH oxidase enzyme plays an important role in neuroprotective effects against cognitive impairment via inhibition of NAPDH oxidase-mediated oxidative stress.
Random walk hierarchy measure: What is more hierarchical, a chain, a tree or a star?
Authors: Czégel Dániel , Palla Gergely 
Published: December 2015

AbstractSigns of hierarchy are prevalent in a wide range of systems in nature and society. One of the key problems is quantifying the importance of hierarchical organisation in the structure of the network representing the interactions or connections between the fundamental units of the studied system. Although a number of notable methods are already available, their vast majority is treating all directed acyclic graphs as already maximally hierarchical. Here we propose a hierarchy measure based on random walks on the network. The novelty of our approach is that directed trees corresponding to multi level pyramidal structures obtain higher hierarchy scores compared to directed chains and directed stars. Furthermore, in the thermodynamic limit the hierarchy measure of regular trees is converging to a well defined limit depending only on the branching number. When applied to real networks, our method is computationally very effective, as the result can be evaluated with arbitrary precision by subsequent multiplications of the transition matrix describing the random walk process. In addition, the tests on real world networks provided very intuitive results, e.g., the trophic levels obtained from our approach on a food web were highly consistent with former results from ecology.
Biofortification of oilseed Brassica juncea with the anti-cancer compound glucoraphanin by suppressing GSL-ALK gene family
Authors: Augustine Rehna , Bisht Naveen C. 
Published: December 2015

AbstractGlucosinolates are amino acids derived secondary metabolites, invariably present in Brassicales, which have huge health and agricultural benefits. Sulphoraphane, the breakdown product of glucosinolate glucoraphanin is known to posses anti-cancer properties. AOP (2-oxoglutarate-dependent dioxygenases) or GSL-ALK enzyme catalyzes the conversion of desirable glucoraphanin to deleterious gluconapin and progoitrin, which are present in very high amounts in most of the cultivable Brassica species including Brassica juncea. In this study we showed that B. juncea encodes four functional homologs of GSL-ALK gene and constitutive silencing of GSL-ALK homologs resulted in accumulation of glucoraphanin up to 43.11 μmoles g−1 DW in the seeds with a concomitant reduction in the anti-nutritional glucosinolates. Glucoraphanin content was found remarkably high in leaves as well as sprouts of the transgenic lines. Transcript quantification of high glucoraphanin lines confirmed significant down-regulation of GSL-ALK homologs. Growth and other seed quality parameters of the transgenic lines did not show drastic difference, compared to the untransformed control. High glucoraphanin lines also showed higher resistance towards stem rot pathogen Sclerotinia sclerotiorum. Our results suggest that metabolic engineering of GSL-ALK has huge potential for enriching glucoraphanin content and improve the oil quality and vegetable value of Brassica crops.
Characteristics and treatment outcomes of pan-urothelial cell carcinoma: a descriptive analysis of 45 patients
Authors: Fang Dong , Liu Pei , Li Xuesong , Xiong Gengyan , Zhang Lei , Singla Nirmish , Zhao Guangzhi , He Qun , He Zhisong , Zhou Liqun 
Published: December 2015

AbstractThe incidence of pan-urothelial cell carcinoma (panUCC), which refers to the presence of both bilateral (UTUC) and bladder tumor (BT), is relatively low. However, the profile of a panUCC cohort of patients remains to be elucidated. We reviewed the data of consecutive UTUC patients who received treatment at our center from 1999 to 2012. Overall, 45 patients were included in this study, with a median age of 64.5 years. Fourteen patients initially presented with unilateral UTUC, 11 initially with BT and the remainder with multiple tumors. Patients with UTUC were more likely to manifest higher rates of muscle invasion and larger-sized tumors. Five patients were treated with complete urinary tract exenteration (CUTE) and most patients (73.3%) received combined management with conservative and radical surgery. After a median follow-up of 77 months, 18 patients (40%) died including 15 (33.3%) due to cancer. Higher tumor stage was the only risk factor predictive of worse survival. Nineteen patients experienced local recurrence after conservative surgery. This study indicated that PanUCC involves either synchronous or metachronous presentation of tumors with a high risk of tumor recurrence, progression and dissemination after conservative surgery.
Kondo peak splitting and Kondo dip induced by a local moment
Authors: Niu Pengbin , Shi Yun-Long , Sun Zhu , Nie Yi-Hang , Luo Hong-Gang 
Published: December 2015

AbstractMany features like spin-orbit coupling, bias and magnetic fields applied and so on, can strongly influence the Kondo effect. One of the consequences is Kondo peak splitting. However, Kondo peak splitting led by a local moment has not been investigated systematically. In this research we study theoretically electronic transport through a single-level quantum dot exchange coupled to a local magnetic moment in the Kondo regime. We focus on the Kondo peak splitting induced by an anisotropic exchange coupling between the quantum dot and the local moment, which shows rich splitting behavior. We consider the cases of a local moment with S = 1/2 and S = 1. The longitudinal (z-component) coupling plays a role of multivalued magnetic fields and the transverse (x, y-components) coupling lifts the degeneracy of the quantum dot, both of which account for the fine Kondo peak splitting structures. The inter-level or intra-level transition processes are identified in detail. Moreover, we find a Kondo dip at the Fermi level under the proper parameters. The possible experimental observations of these theoretical results should deepen our understanding of Kondo physics.