bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: N,2‐Dibromo‐6‐chloro‐3,4‐dihydro‐2H‐benzo[e] [1,2,4]thiadiazine‐7‐sulfonamide 1,1‐Dioxide: An Efficient and Homogeneous Catalyst for One‐Pot Synthesis of 4H‐Pyran, Pyranopyrazole and Pyrazolo[1,2‐b]phthalazine Derivatives under Aqueous Media.
Authors: Khazaei Ardeshir , Zolfigol Mohammad Ali , Karimitabar Fatemeh , Nikokar Iraj , Moosavi‐Zare Ahmad Reza 
Published: January 2016

AbstractA wide range of the title compounds are conveniently obtained under aqueous, environmentally friendly reaction conditions.
ChemInform Abstract: Diversity‐Oriented Approach to Cyclophanes via Fischer Indolization and Ring‐Closing Metathesis: Substrate‐Controlled Stereochemical Outcome in RCM.
Authors: Kotha Sambasivarao , Chinnam Ajay Kumar , Shirbhate Mukesh E. 
Published: January 2016

AbstractIt is found that the configuration of the double bond formed during the RCM depends on the order of the synthetic route.
ChemInform Abstract: Palladium‐Catalyzed Allylic Alkylation Reactions of Glycolates as a Tool for the Synthesis of Functionalized α‐Hydroxy Esters.
Authors: Kiefer Alexander , Gawas Dnyaneshwar , Kazmaier Uli 
Published: January 2016

AbstractAn optimized protocol allows the introduction of side chains into the tert‐butyl glycolate (I) using allyl acetates.
ChemInform Abstract: Chiral Cu(II)‐Catalyzed Enantioselective β‐Borilation of α,β‐Unsaturated Nitriles in Water.
Authors: Zhu Lei , Kitanosono Taku , Xu Pengyu , Kobayashi Shu 
Published: January 2016

AbstractFor the title reaction, good enantioselectivities are achieved by using a chiral 2,2′‐bipyridine ligand.
ChemInform Abstract: The Carbonyl Group Tuned Electron‐Deficient Phosphorus Ligands and Their Application in Rhodium Catalyzed Arylation to Aldehydes.
Authors: Yang Jiefang , Chen Xingyu , Wang Zhiqian 
Published: January 2016

AbstractThe shown ligand exhibits the best activity because of accelerating the transmetalation step in the Rh‐catalyzed reaction of aldehydes with arylboronic acids.
ChemInform Abstract: Rhodium(III)‐Catalyzed Internal Oxidative Coupling of N‐Hydroxyanilides with Alkenes via C—H Activation.
Authors: Wen Jing , Wu An , Chen Pei , Zhu Jin 
Published: January 2016

AbstractThe ortho‐selective olefination of N‐hydroxyanilides is directed by the N‐hydroxy group which also acts as the required oxidant.
ChemInform Abstract: In situ Protection and Deprotection of Amines for Iron Catalyzed Oxidative Amidation of Aldehydes.
Authors: Bathini Thulasiram , Rawat Vikas S. , Bojja Sreedhar 
Published: January 2016

AbstractCarbon dioxide is found to be the ideal protecting group for the in situ protection and deprotection of amines for the oxidative amination of aldehydes.
ChemInform Abstract: Visible‐Light‐Induced Meerwein Cascade Reactions for the Preparation of α‐Aryl Esters.
Authors: Niu Teng‐fei , Li Liang , Ni Bang‐qing , Bu Mei‐jie , Cai Chun , Jiang Hui‐liang 
Published: January 2016

AbstractThe transformations are carried out at room temperature in the presence of molecular O2 as the oxidant.
ChemInform Abstract: Synthesis of Aryl Tri‐ and Difluoromethyl Thioethers via a C—H‐Thiocyanation/Fluoroalkylation Cascade.
Authors: Jouvin Kevin , Matheis Christian , Goossen Lukas J. 
Published: January 2016

AbstractThe synthesis of aryl trifluoromethyl thioethers and aryl difluoromethyl thioethers proceed with remarkable regioselectivity for the most electron‐rich, sterically least hindered position of the arene.
ChemInform Abstract: Palladacycles Derived from Arylphosphinamides for Mild Suzuki—Miyaura Cross‐Couplings.
Authors: Wu Guo‐Jie , Han Fu‐She , Zhao Yu‐Long 
Published: January 2016

AbstractA wide variety of biaryls is synthesized through Suzuki—Miyaura cross‐coupling of aryl bromides or aryl triflates with (het)aryl boronic acids.
ChemInform Abstract: An Efficient Zinc‐Catalyzed Cross‐Coupling Reaction of Aryl Iodides with Terminal Aromatic Alkynes.
Authors: Thankachan Amrutha P. , Sindhu K. S. , Krishnan K. Keerthi , Anilkumar Gopinathan 
Published: January 2016

AbstractDepending on the functional groups of the aryl substituent, the products are obtained in moderate to high yields.
ChemInform Abstract: Superacid Mediated Intramolecular Condensation: Facile Synthesis of Indenones and Indanones.
Authors: Ramulu Bokka Venkat , Satyanarayana Gedu 
Published: January 2016

AbstractIt is shown that the intramolecular acylation leads to a rearrangement of the olefin bond to the exo‐position of the five‐membered rings.
ChemInform Abstract: Palladium(II)‐Catalyzed Tandem Oxidative Acetoxylation/ortho C—H Activation/Carbocyclization of Arylallenes.
Authors: Mazuela Javier , Banerjee Debasis , Baeckvall Jan‐E. 
Published: January 2016

AbstractThis novel and efficient title reaction gives access to synthetically important functionalized indenes.
ChemInform Abstract: MeOTf‐Induced Carboannulation of Isothiocyanates and Aryl Alkynes with C=S Bond Cleavage: Access to Indenones.
Authors: Zhao Peng , Liu Yu , Xi Chanjuan 
Published: January 2016

AbstractA triflate‐induced cyclization of isothiocyanates and aryl alkynes provides indenones containing a 3‐methylthio moiety in good yields under metal‐free conditions.
ChemInform Abstract: Hg(OTf)2 Catalyzed Intramolecular 1,4‐Addition of Donor—Acceptor Cyclopropenesto Arenes.
Authors: Deng Yongming , Jing Changcheng , Zavalij Peter Y. , Doyle Michael P. 
Published: January 2016

AbstractThe title reaction is described to yield bicyclo[3.2.2]nonatriene derivatives (II) and (V) as sole or main products.
ChemInform Abstract: Chiral Octahedral Complexes of Co(III) as Catalysts for Asymmetric Epoxidation of Chalcones under Phase Transfer Conditions.
Authors: Larionov Vladimir A. , Markelova Elina P. , Smol'yakov Alexander F. , Savel'yeva Tat'yana F. , Maleev Victor I. , Belokon Yuri N. 
Published: January 2016

AbstractThe same type of catalyst is found to catalyze the coupling of the obtained epoxide (IIIa) with CO2.
ChemInform Abstract: Diastereoselective Synthesis of syn‐β‐Lactams Using Rh‐Catalyzed Reductive Mannich‐Type Reaction of α,β‐Unsaturated Esters.
Authors: Isoda Motoyuki , Sato Kazuyuki , Funakoshi Masato , Omura Keiko , Tarui Atsushi , Omote Masaaki , Ando Akira 
Published: January 2016

AbstractReaction conditions are optimized for the Rh‐hydride complex catalyzed reaction of α,β‐unsaturated esters with imines to give syn‐3,4‐disubstituted β‐lactams.
ChemInform Abstract: A New Strategy for Enantioselective Construction of Multisubstituted Five‐Membered Oxygen Heterocycles via a Domino Michael/Hemiketalization Reaction.
Authors: Hua Yuan‐Zhao , Liu Meng‐Meng , Huang Pei‐Jin , Song Xixi , Wang Min‐Can , Chang Jun‐Biao 
Published: January 2016

AbstractThe reaction of α‐hydroxyacetophenone (II) with a series of β,γ‐unsaturated α‐keto esters under conditions A) affords tetrasubstituted furans (III) with excellent e.e.
ChemInform Abstract: Hydroxoiridium/Chiral Diene Complexes as Effective Catalysts for Asymmetric Annulation of α‐Oxo‐ and Iminocarboxamides with 1,3‐Dienes.
Authors: Hatano Miyuki , Nishimura Takahiro 
Published: January 2016

AbstractA broad spectrum of highly functionalized γ‐lactam structures is available in high yields and with excellent enantioselectivities in the presence of the Ir catalyst containing ligand (I).
ChemInform Abstract: Copper‐Catalyzed Aerobic Oxidative Dehydrogenative Formal [2 + 3] Cyclization of Glycine Esters with α‐Angelicalactone: Approach to Construct Polysubstituted Pyrrolidones.
Authors: Huo Congde , Yuan Yong , Chen Fengjuan , Tang Jing , Wang Yajun 
Published: January 2016

AbstractThe scalable reaction delivers a diastereomeric mixture of 3‐acetyl‐4‐methoxycarbonyl substituted pyrrolidinones, and depending on the N‐aryl substituent the products are obtained in low to high yields.
ChemInform Abstract: Ring Contraction of 3‐Hydroxy‐3‐(trifluoromethyl)piperidines: Synthesis of 2‐Substituted 2‐(Trifluoromethyl)pyrrolidines.
Authors: Feraldi‐Xypolia Alexandra , Gomez Pardo Domingo , Cossy Janine 
Published: January 2016

AbstractThe key step for the synthesis of the title pyrrolidines is the Tf2O‐induced ring contraction of piperidine (I) leading to the key aziridinium intermediate which is regioselectively opened by different nucleophiles, such as alcohols, amines, thiols, carbanions, or halides.
ChemInform Abstract: Rhodium‐Catalyzed C—H Annulation of Nitrones with Alkynes: A Regiospecific Route to Unsymmetrical 2,3‐Diaryl‐Substituted Indoles.
Authors: Yan Hao , Wang Haolong , Li Xincheng , Xin Xiaoyi , Wang Chunxiang , Wan Boshun 
Published: January 2016

AbstractN‐Phenyl‐α‐arylnitrones react with symmetrical dialkylacetylenes to form unsymmetrically 2,3‐diaryl‐substituted N‐unprotected indole derivatives in moderate to often high yields.
ChemInform Abstract: Di‐tert‐butyl Peroxide (DTBP) Promoted Dehydrogenative Coupling: An Expedient and Metal‐Free Synthesis of Oxindoles via Intramolecular C(sp2)—H and C(sp3)—H Bond Activation.
Authors: Mondal Biplab , Roy Brindaban 
Published: January 2016

AbstractA variety of oxindoles is efficiently synthesized through intramolecular dehydrogenative coupling using di‐tert‐butyl peroxide as the oxidant.
ChemInform Abstract: Visible‐Light Photoredox Catalysis: Direct Synthesis of Sulfonated Oxindoles from N‐Arylacrylamides and Arylsulfinic Acids by Means of a Cascade C—S/C—C Formation Process.
Authors: Xia Dong , Miao Tao , Li Pinhua , Wang Lei 
Published: January 2016

AbstractThe method allows the access to a broad spectrum of functionalized oxindoles including higher ring systems (XII) and (XIV).
ChemInform Abstract: DABCO‐Catalyzed sp3 C—H Activation: Rapid Access to Isoxazole or Coumarin‐Fused 3‐Quaternary Carbon Oxindoles and Isoxazole‐Fused Pyrrolidinones.
Authors: Liu Xiong‐Li , Jing De‐Hong , Yao Zhen , Zhang Wen‐Hui , Liu Xiong‐Wei , Yang Zhou‐Jie , Zhao Zhi , Zhou Ying , Li Xiao‐Nian 
Published: January 2016

AbstractMost of the products show in vitro inhibition activity against Staphylococcus aureus (MTCC96) comparable to Penicillin.
ChemInform Abstract: Structure and Reactivity of Indolylmethylium Ions: Scope and Limitations in Synthetic Applications.
Authors: Follet Elsa , Berionni Guillaume , Mayer Peter , Mayr Herbert 
Published: January 2016

AbstractThe reactivity of the title compounds with π‐nucleophiles (silylated enol ethers and ketone acetals) is kinetically studied using photometric monitoring at 20°C.
ChemInform Abstract: Broensted Acid‐Catalyzed Cascade Reactions Involving 1,2‐Indole Migration.
Authors: Alvarez Estela , Nieto Faza Olalla , Silva Lopez Carlos , Fernandez‐Rodriguez Manuel A. , Sanz Roberto 
Published: January 2016

AbstractVarious indole‐functionalized benzofulvene derivatives are obtained by a cascade reaction of indoles with propargylic diols involving an unusual metal‐free 1,2‐indole migration onto an alkyne.
ChemInform Abstract: Preparation of 1,2,5‐Trisubstituted 1H‐Imidazoles from Ketenimines and Propargylic Amines by Silver‐Catalyzed or Iodine‐Promoted Electrophilic Cyclization Reaction of Alkynes.
Authors: Zhou Xiaorong , Jiang Zheng , Xue Lexing , Lu Ping , Wang Yanguang 
Published: January 2016

AbstractIn the presence of AgOTf [cf.
ChemInform Abstract: CuI/CuBr2‐Catalyzed Decarboxylative/A3 Reaction of Propiolic Acids for the Facile Synthesis of 1,4‐Diheterocycle‐2‐butynes.
Authors: Feng Huangdi , Zhao Panfeng , Sun Zhihua 
Published: January 2016

AbstractA facile one‐pot protocol is developed for the decarboxylative coupling of propiolic acid, aminoalcohols, and formaldehyde to give 1,4‐disubstituted but‐2‐ynes.
ChemInform Abstract: Utilization of Copper‐Catalyzed Carboarylation—Ring Closure for the Synthesis of New Oxazoline Derivatives.
Authors: Sinai Adam , Vangel Dora , Gati Tamas , Bombicz Petra , Novak Zoltan 
Published: January 2016

Abstract1‐Aryl and 1‐alkylpropargylamides are transformed with arylmesityliodonium salts to deliver oxazoline derivatives with a fully substituted exo double bond in moderate to high yields.
ChemInform Abstract: Synthesis of 1,2,4‐Triazoles via Oxidative Heterocyclization: Selective C—N Bond over C—S Bond Formation.
Authors: Gogoi Anupal , Guin Srimanta , Rajamanickam Suresh , Rout Saroj Kumar , Patel Bhisma K. 
Published: January 2016

AbstractEither 1,2,4‐triazole‐thiones or 1,2,4‐triazoles are efficiently obtained from arylidenearylthiosemicarbazides by simple tuning of the reaction time.
ChemInform Abstract: Stereoselective and Regiodivergent Allylic Suzuki—Miyaura Cross‐Coupling of 2‐Ethoxydihydropyranyl Boronates: Synthesis and Confirmation of Absolute Stereochemistry of Diospongin B.
Authors: Rybak Taras , Hall Dennis G. 
Published: January 2016

AbstractDepending on the ligand used the title reaction of chiral 2‐ethoxydihydropyranyl‐4‐pinacolate with (het)aryl and alkenylbromides delivers either α‐ or γ‐substituted coupling products.
ChemInform Abstract: An Easy Access to Chromanes via the Gold‐Catalyzed Hydroarylation of Allenes.
Authors: Fazeli Azadeh , Pflaesterer Daniel , Rudolph Matthias , Hashmi A. Stephen K. 
Published: January 2016

AbstractThe gold‐catalyzed intramolecular hydroallylation of allenes is used for the synthesis of chromanes with an exocyclic double bond.
ChemInform Abstract: Palladium(II)‐Catalyzed Regioselective Synthesis of 3,4‐Disubstituted Quinolines and 2,3,5‐Trisubstituted Pyrroles from Alkenes via anti‐Markovnikov Selectivity.
Authors: Senadi Gopal Chandru , Hu Wan‐Ping , Garkhedkar Amol Milind , Boominathan Siva Senthil Kumar , Wang Jeh‐Jeng 
Published: January 2016

AbstractAn efficient, scalable reaction of 2‐acylanilines with various 1‐arylalkenes, acrylic acid derivatives, cycloalkenones or naphthoquinone to 3,4‐disubstituted quinolines is described which is not applicable to cyclic or acyclic aliphatic alkenes.
ChemInform Abstract: An Enantioselective Synthesis of Spirobilactams Through Copper‐Catalyzed Intramolecular Double N‐Arylation and Phase Separation.
Authors: Liu Jianguang , Tian Yingying , Shi Jialing , Zhang Shasha , Cai Qian 
Published: January 2016

AbstractA series of title compounds is prepared as building blocks for functional chiral molecules.
ChemInform Abstract: Enantioselective Organocatalytic Transfer Hydrogenation of 1,2‐Dihydroquinoline Through Formation of Aza‐o‐xylylene.
Authors: Li Guangxun , Liu Hongxin , Lv Gang , Wang Yingwei , Fu Qingquan , Tang Zhuo 
Published: January 2016

AbstractThe developed method provides the products in high yields and with high enantiomeric excess, but requires the presence of an electron‐donating substituent in position 7 of the dihydroquinoline substrates to proceed.
ChemInform Abstract: Stereoselective Synthesis of Functionalized 1,2,3,4‐Tetrahydroisoquinolines (THIQs) via Highly Diastereoselective Ugi Three‐Component Reactions (U3CRs) with Chiral 3,4‐Dihydroisoquinolines (DHIQs).
Authors: Ramanivas T. , Gayatri G. , Priyanka D. , Nayak V. L. , Singarapu K. K. , Srivastava A. K. 
Published: January 2016

AbstractA protocol is presented for the synthesis of enantiopure THIQs from DHIQs, isocyanides, and aromatic or aliphatic carboxylic acids.
ChemInform Abstract: Photoredox‐Catalyzed Tandem Insertion/Cyclization Reactions of Difluoromethyl and 1,1‐Difluoroalkyl Radicals with Biphenyl Isocyanides.
Authors: Zhang Zuxiao , Tang Xiaojun , Dolbier William R. Jr. 
Published: January 2016

AbstractDifluoroalkyl radicals generated from sulfonyl chlorides (II) and (IV) or bromide (VI) undergo radical isonitrile insertion reactions to provide access to phenanthridine derivatives under mild conditions.
ChemInform Abstract: Generation of α‐Imino Gold Carbenes Through Gold‐Catalyzed Intermolecular Reaction of Azides with Ynamides.
Authors: Shu Chao , Wang Yong‐Heng , Zhou Bo , Li Xin‐Ling , Ping Yi‐Fan , Lu Xin , Ye Long‐Wu 
Published: January 2016

AbstractThe title reaction of ynamides of type (I), (IV), and (VI) with benzylic azides (II) offers a highly regioselective access to 2‐aminoindoles (III) and (V).
ChemInform Abstract: Copper‐Catalyzed Oxidative Annulation Between 2‐Aminopyridine and Arylidenemalononitrile Leading to 4‐Oxo‐pyrido[1,2‐a]pyrimidine‐3‐carbonitrile.
Authors: Mishra Subhajit , Hajra Alakananda 
Published: January 2016

AbstractThe new strategy for the synthesis of pyridopyrimidines (III) and (V) involves sequential aza‐Michael addition, aerobic dehydrogenation, and intramolecular amination.
ChemInform Abstract: Alcohols as Alkylating Agents in Heteroarene C—H Functionalization.
Authors: Jin Jian , MacMillan David W. C. 
Published: January 2016

AbstractA mild and simple alkylation reaction utilizing a combination of photoredox and thiol hydrogen atom transfer organocatalysis for the formation of heteroaryl C—C bonds using alcohols as latent nucleophiles is developed.
ChemInform Abstract: Palladium‐Catalyzed Dearomative Cyclocarbonylation by C—N Bond Activation.
Authors: Yu Hui , Zhang Guoying , Huang Hanmin 
Published: January 2016

AbstractA fundamentally novel approach to bioactive quinolizinone structures based on the Pd‐catalyzed cyclocarbonylation of azaarene‐substituted allylamines is developed.
ChemInform Abstract: Expeditious Synthesis of 2‐Phenylquinazolin‐4‐amines via a Fe/Cu Relay‐Catalyzed Domino Strategy.
Authors: Jia Feng‐Cheng , Zhou Zhi‐Wen , Xu Cheng , Cai Qun , Li Deng‐Kui , Wu An‐Xin 
Published: January 2016

AbstractThe process is based on an elegant domino reaction between ortho‐brominated, chlorinated, iodinated, or fluorinated benzonitriles, aryl or hetarylaldehydes, and sodium azide.
ChemInform Abstract: Dual Behavior of Ammonium Acetate for the Synthesis of Diverse Symmetrical/Unsymmetrical Bis[1,3]oxazines Possessing Anticancer Activity.
Authors: Ramachandran Gunasekar , Sathiyanarayanan Kulathu Iyer , Sathishkumar Munusamy , Rathore Ravindranath S. , Giridharan Periyasamy 
Published: January 2016

AbstractA simple and efficient approach is reported to synthesize symmetrical and unsymmetrical bis[1,3]oxazines using ammonium acetate with controllable substitution patterns in a one‐pot fashion.
ChemInform Abstract: Enantioselective Synthesis of Medium‐Sized‐Ring Lactones by Organocatalytic Michael Addition Followed by Reductively Initiated Fragmentation.
Authors: Roudier Mylene , Constantieux Thierry , Quintard Adrien , Rodriguez Jean 
Published: January 2016

AbstractAn efficient approach to the title compounds as scaffolds in biologically active natural products is developed.
ChemInform Abstract: Iron‐Catalyzed Reduction of CO2 into Methylene: Formation of C—N, C—O, and C—C Bonds.
Authors: Jin Guanghua , Werncke C. Gunnar , Escudie Yannick , Sabo‐Etienne Sylviane , Bontemps Sebastien 
Published: January 2016

AbstractBased on the use of a (dihydrido)iron complex as catalyst the conversion of hydroboranes to bis(boryl)acetal (III) using CO2 as one‐carbon source is optimized.
ChemInform Abstract: Copper‐Mediated Reaction of Oxazirconacyclopentenes with Dichlorophenylphosphine: A New Pathway for the Formation of 1,2‐Oxaphosphole Derivatives.
Authors: Zhou Yiqing , Wang Sheng , Chen Chao , Xi Chanjuan 
Published: January 2016

AbstractOxaphosphole derivatives are conveniently obtained in one‐pot from alkynes, carbonyl compounds, and dichlorophosphine in reaction with a zirconocene compound.
ChemInform Abstract: A Convenient Synthesis of Phosphonomethyl α,β‐Unsaturated γ‐Lactams.
Authors: Abdelli Abderrahmen , Efrit Mohamed Lotfi , Gaucher Anne , M'rabet Hedi , Prim Damien 
Published: January 2016

AbstractAn efficient method for the preparation of a novel family of functionalized phosphonomethyl α,β‐unsaturated γ‐lactams is established.
ChemInform Abstract: (.+‐.)‐Salviaprione, a Pair of Unprecedented Abietane‐Type Diterpeniods from Salvia prionitis.
Authors: Jiang Yong‐Jun , Zhang Yu , He Juan , Wu Xing‐De , Shao Li‐Dong , Li Xiao‐Nian , Su Jia , Peng Li‐Yan , Li Rong‐Tao , Zhao Qin‐Shi 
Published: January 2016

Abstract(+)‐Salviaprione and (‐)‐salviaprione are isolated from the whole plant of Salvia prionitis.
ChemInform Abstract: Novel Monoterpene Lactones from Cinnamomum inunctum
Authors: Fuchino Hiroyuki , Yazawa Aya , Kiuchi Fumiyuki , Kawahara Nobuo , Takahashi Yutaka , Satake Motoyoshi 
Published: January 2016

Abstractisolation and structure elucidation of four novel monoterpene lactones
ChemInform Abstract: (+)‐ and (‐)‐Pestaloxazine A, a Pair of Antiviral Enantiomeric Alkaloid Dimers with a Symmetric Spiro[oxazinane‐piperazinedione] Skeleton from Pestalotiopsis sp.
Authors: Jia Yan‐Lai , Wei Mei‐Yan , Chen Hai‐Yan , Guan Fei‐Fei , Wang Chang‐Yun , Shao Chang‐Lun 
Published: January 2016

AbstractEnantiomer [(+)‐I] is shown to exhibit potent antiviral activity.
ChemInform Abstract: In Situ Analysis of Catalytically Active Pd Surfaces for CO Oxidation with Near Ambient Pressure XPS
Authors: Kondoh Hiroshi , Toyoshima Ryo , Monya Yuji , Yoshida Masaaki , Mase Kazuhiko , Amemiya Kenta , Mun Bongjin Simon 
Published: January 2016

AbstractReview: 45 refs.
ChemInform Abstract: A New Approach to Modification of Rearrangements in Metallorganic Chemistry of Phosphorus, Arsenic, Antimony and Bismuth
Authors: Zhakenovich Aibassov Yerkin , Stepanovna Yemelyanova Valentina , Vladimirovna Shakieva Tatyana , Gizatulla Aibassov , Bakhyt Abenov , Maksat Bulenbayev 
Published: January 2016

AbstractReview: 100 refs.
Work stealing for GPU‐accelerated parallel programs in a global address space framework
Authors: Arafat Humayun , Dinan James , Krishnamoorthy Sriram , Balaji Pavan , Sadayappan P. 
Published: January 2016

SummaryTask parallelism is an attractive approach to automatically load balance the computation in a parallel system and adapt to dynamism exhibited by parallel systems. Exploiting task parallelism through work stealing has been extensively studied in shared and distributed‐memory contexts. In this paper, we study the design of a system that uses work stealing for dynamic load balancing of task‐parallel programs executed on hybrid distributed‐memory CPU‐graphics processing unit (GPU) systems in a global‐address space framework. We take into account the unique nature of the accelerator model employed by GPUs, the significant performance difference between GPU and CPU execution as a function of problem size, and the distinct CPU and GPU memory domains. We consider various alternatives in designing a distributed work stealing algorithm for CPU‐GPU systems, while taking into account the impact of task distribution and data movement overheads. These strategies are evaluated using microbenchmarks that capture various execution configurations as well as the state‐of‐the‐art CCSD(T) application module from the computational chemistry domain. Copyright © 2016 John Wiley & Sons, Ltd.
Chromosome engineering in zygotes with CRISPR/Cas9
Authors: Boroviak Katharina , Doe Brendan , Banerjee Ruby , Yang Fengtang , Bradley Allan 
Published: January 2016

SUMMARYDeletions, duplications, and inversions of large genomic regions covering several genes are an important class of disease causing variants in humans. Modeling these structural variants in mice requires multistep processes in ES cells, which has limited their availability. Mutant mice containing small insertions, deletions, and single nucleotide polymorphisms can be reliably generated using CRISPR/Cas9 directly in mouse zygotes. Large structural variants can be generated using CRISPR/Cas9 in ES cells, but it has not been possible to generate these directly in zygotes. We now demonstrate the direct generation of deletions, duplications and inversions of up to one million base pairs by zygote injection. genesis 54:78–85, 2016. © 2016 The Authors. genesis Published by Wiley Periodicals, Inc.