bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caring for Hindu patients at the end-of-life: A narrative review
Authors: Raval Raniga Brinda , Kumar Savannah , McAteer Martin Rebecca , Blinderman Craig D. 
Published: October 2024

AbstractObjectivesThis paper reviews the existing literature to identify specific challenges that may arise in the context of providing palliative and end-of-life (EOL) care for Hindu patients in the physical, psychological, and spiritual domains. We offer practical strategies where appropriate to mitigate some of these challenges. We review how the Hindu faith impacts EOL decision-making, including the role of the family in decision-making, completion of advance directives, pain management, and decisions around artificial nutrition and hydration (ANH) and cardiopulmonary resuscitation (CPR).MethodsThe PubMed, MEDLINE Complete, Cochrane, and Embase databases were searched for articles using the search strings combinations of keywords such as Palliative care, Hindu, Hinduism, End of Life Care, India, Spirituality, and South Asian. Once inclusion criteria were applied, 40 manuscripts were eligible for review.ResultsOur results are organized into the following 4 sections – how Hindu religious or spiritual beliefs intersect with the physical, psychological, and spiritual domains: and decision-making at the EOL.Significance of resultsHindu beliefs, in particular the role of karma, were shown to impact decision-making regarding pain management, ANH and CPR, and advance directive completion. The complexity of Hindu thought leaves a significant role for interpretation and flexibility for individual factors in decision-making at the EOL.
Thiamine deficiency as a differential diagnosis for severe fatigue in terminally ill cancer patients
Authors: Onishi Hideki , Sato Hiroko , Uchida Nozomu , Yoshioka Akira , Sato Izumi , Onizawa Nobuyuki , Ito Hiroshi , Ishida Mayumi 
Published: October 2024

AbstractObjectivesPatients with advanced cancer present various symptoms as their disease progresses. Among these, fatigue is a frequent symptom in patients with advanced cancer and is associated with decreased quality of life (QOL). However, there are few reports regarding its association with thiamine deficiency (TD).MethodsWe report a case in which we found TD in a patient with advanced lung cancer who presented with weight loss, significant fatigue, and appeared to have a worsening general condition, for whom symptoms were dramatically improved within a short period of time by intravenous administration of thiamine.ResultsThe patient was a 76-year-old woman who had been diagnosed with lung cancer and liver metastases 6 months earlier. Due to interstitial pneumonia, she was not a candidate for chemotherapy and so palliative care was started. At 8 months after initial diagnosis, the patient complained of fatigue during a medical examination, so a blood sample was taken. A week later, she visited the hospital with a cane. She felt extremely fatigued and was unable to stand, but results from the previous blood test revealed that a TD. The fatigue disappeared 15 minutes after intravenous administration of thiamine and she was able to return home without the cane.Significance of resultsFatigue is a frequent symptom in advanced cancer patients, and TD may be the underlying cause. Inclusion of TD in the differential diagnosis may contribute to improving patient QOL.
Reconstruction of the Hydro‐Thermal Behavior of Regulated River Networks of the Columbia River Basin Using Satellite Remote Sensing and Data‐Driven Techniques
Authors: Darkwah G. K. , Hossain Faisal , Tchervenski Victoria , Holtgrieve Gordon , Graves David , Seaton Charles , Minocha Sanchit , Das Pritam , Khan Shahzaib , Suresh Sarath 
Published: October 2024

AbstractThe use of satellite‐based thermal infrared remote sensing has facilitated the assessment of surface water temperature on a large scale. However, the inherent limitations of this remote sensing technique make it difficult to assess rivers unless ambient conditions are cloud‐free, devoid of steep terrain and the rivers are at least 60 m wide. To address these challenges that limit the spatiotemporal continuity of satellite‐based hydro‐thermal data, we harnessed the extensive coverage from the Landsat missions' thermal infrared sensors and data‐driven techniques to estimate surface water temperature of rivers. Out of the tested data‐driven techniques, we selected the Random Forest Regressor as our prime non‐linear approach for estimation of surface water temperature in rivers. Using the selected technique, proposed as THORR (Thermal History of Regulated Rivers), we successfully reconstructed a multi‐decadal, continuous spatiotemporal surface water temperature record for regulated rivers in the Columbia River Basin. Using 42 years of data, the surface water temperature could be predicted on average with 0.71° C of absolute error regardless of the dam's potential thermal influence in the downstream reaches. The reconstructed hydro‐thermal behavior generated from THORR revealed a long‐term downstream warming trend along the Columbia River. The open‐source THORR tool can be extended to any river system around the world that is not gauged with in‐situ temperature measurements for the reconstruction of hydro‐thermal behavior.
Multi‐Stage Magmatism During Slab Exhumation Drives the Geochemical Evolution of Continental Crust: Insights From Paleozoic Granitoids in South Altyn, Western China
Authors: Tian Long , Liu Liang , Chen Danling , Cao Yuting , Gai Yongsheng , Ma Tuo , Wang Qian , Kang Lei 
Published: October 2024

AbstractThe present continental crust is characterized by a felsic upper crust and a mafic lower crust, resulting from significant geochemical differentiation over geological time. While various processes have been proposed to explain this differentiation, subduction zones remain pivotal regions for understanding the compositional evolution of continental crust. This study focuses on the South Altyn (SA) continental subduction‐collision belt in western China, a unique setting that experienced ultra‐deep (>300 km) continental subduction followed by multi‐stage exhumation. We present a comprehensive study of four granitoid suites from Tatelekebulake (TTLK) area in SA: biotite granite (BG), monzogranite (MG), K‐feldspar granite (KG), and leucogranite (LG). Comprehensive studies on petrology, geochemistry and zircon U‐Pb dating show that these granitoids formed at 494, 451, 414, and 418 Ma, respectively, and originated from protoliths with affinity to the subducted continental crust in SA. Phase equilibrium modeling suggests that BG formed at ∼800°C and 0.6 GPa, while the MG, KG, and LG formed by differentiation crystallization of the BG magma under progressively decreasing temperature and pressure conditions (750°C, 0.5 GPa; 740–700°C, 0.2 GPa; and 700–640°C, 0.1 GPa, respectively). These results, combined with previous studies, allow us to reconstruct the tectonic processes of continental exhumation and subsequent orogenic collapse in SA during the Early Paleozoic. Importantly, our findings reveal that magmatism derived from partial melting of subducted continental crust can promote the geochemical evolution of continental crust toward more felsic compositions, even in the absence of significant crustal growth or mantle‐derived magmatism. This study provides a valuable case for understanding the compositional evolution of continental crust in deep subduction zones and challenges conventional models that rely heavily on arc magmatism for crustal differentiation. Moreover, our results contribute to a broader understanding of crustal evolution processes in collisional orogens worldwide and highlight the importance of recycling and differentiation of subducted continental material in shaping crustal compositions.
Patterns of Plio‐Pleistocene Ice Volume Variability Recorded by the Large‐Magnitude Explosive Eruptions From the Kamchatka‐Kurile Volcanic Arc
Authors: Straub Susanne M. , Reilly Brendan , Raymo Maureen E. , Gómez‐Tuena Arturo , Wang Kuo‐Lung , Widom Elisabeth , Kuentz David , Arculus Richard J. 
Published: October 2024

AbstractMarine fallout ash beds can provide continuous, time‐precise records of highly explosive arc volcanism that can be linked with the climate record. An evaluation of revised Plio‐Pleistocene (0–4 Myr) tephrostratigraphies from Ocean Drilling Program Sites 881, 882, and 884 confirms cyclicity of the Kamchatka‐Kurile arc volcanism and a marked increase just after the intensification of the Northern Hemisphere glaciation at 2.73 Ma. The compositional constancy of the Kamchatka‐Kurile volcano‐magma systems through time points to external modulation of volcanic cyclicity and frequency. The stacked tephra record reveals periodic peaks in arc volcanicity at ∼0.3, ∼1.0, ∼1.6, ∼2.5, and ∼3.8 Myr that coincide with maxima of the global ice volume variability that have been linked with the amplitude modulation of the precession (0.3, 1.0 Myr) and obliquity (1.6, 2.5 and 3.8 Myr) bands. A simple model of a decreasing obliquity variance across the mid‐Pleistocene Transition at constant precession variance produces an excellent correlation of ash bed cycles with the variability of global benthic δ18O (r2 = 0.75), which implies that climate, and not direct orbital forcing, modulates Kamchatka‐Kurile arc volcanism. The rising influence of precession variance in the Kamchatka‐Kurile ash bed record after the mid‐Pleistocene Transition contrasts with the dominant 100 kyr signal in the benthic δ18O global ice volume variability, which may either reflect limitations of the ash bed record or an regional rather than global influence of ice volume variability. Our results indicate that climate influences the Kamchatka‐Kurile arc volcanism, which may influence climate only by feedback.
Air and Surface Temperatures Differently Drive Terrestrial Carbon and Water Cycles in the High Latitudes
Authors: Tang Jing , Chen Shouzhi , Martín Belda David , Rinnan Riikka , Körner Christian , Fu Yongshuo H. 
Published: October 2024

AbstractHigh‐latitude vegetation experience different temperatures than the ambient air temperature. While lacking a regional plant temperature product, we drove the dynamic ecosystem model, LPJ‐GUESS, with widely used ERA5‐land surface temperature (Tsurf, at radiative equilibrium) and air temperature to understand ecosystem process responses to these two temperatures. We show that tundra plants' growth is stimulated by warmer Tsurf in the summer, but in the boreal forests, colder Tsurf in the non‐summer months constrains leaf development and enzyme activity the following growing season. Tsurf drives higher productivity of tundra plant individuals but leads to less productive individuals in the boreal forest, although with compensatory changes (almost 68%) in vegetation structure. We demonstrate the importance of forcing temperature in simulating high‐latitude ecosystem processes and call for a community effort to measure plant temperatures across canopy heights and seasons to reduce uncertainties in estimating high‐latitude plant responses and feedback to climate.
Climate Change Impact on “Outdoor Days” Over the United States
Authors: Choi Yeon‐Woo , Khalifa Muhammad , Eltahir Elfatih A. B. 
Published: October 2024

AbstractThe scientific discourse on climate change throughout the US has primarily revolved around changes in mean climate and/or climate extremes. However, little is known about the impacts of climate change on mild weather conditions despite its significant relevance to quality of life. Here, we adopt the concept of “outdoor days” defined as those relatively pleasant days when most people may enjoy outdoor activities (Choi et al., 2024). We project how climate change reshapes seasonality of US outdoor days: relatively large drops in summer, late spring, and early fall; and a significant increase in winter. However, annual outdoor days are projected to change slightly, with notable exceptions. We project relatively large drops in southeast (−23%), south (−19%), and Ohio Valley (−19%), and a significant increase in northwest (14%) toward the end of the century. Our findings have implications for quality of life in different regions, and for nation‐wide travel and tourism.
The 2022 February 15 Solar Energetic Particle Event at Mars: A Synergistic Study Combining Multiple Radiation Detectors on the Surface and in Orbit of Mars With Models
Authors: Zhang Jian , Guo Jingnan , Zhang Yongjie , Cao Yihang , Dobynde Mikhail I. , Li Cunhui , Yu Yuhong , Wang Yuming , Tang Shuwen , Qian Yi , Zhao Hongyun , Sun Zhiyu , Wang Yi , Wimmer‐Schweingruber Robert F. 
Published: October 2024

AbstractOn 2022‐02‐15, solar eruptions caused one of the most intensive Solar Particle Events (SPEs) in Solar Cycle 25 observed at various heliospheric locations. This study focuses on the enhancements of energetic proton flux observed by multiple detectors located at the orbit and on the surface of Mars. We carry out the first analysis by the Mars Energetic Particle Analyzer (MEPA) instrument on board the Chinese Tianwen‐1 spacecraft (TW‐1) at Mars orbit which also serves to validate the instrument's capability to measure protons of up to 100 MeV. We reconstruct the event spectrum up to 1 GeV and further model the event doses at Mars's orbit and surface which are then validated against the corresponding dosimetry data. Our study utilizes all available radiation detectors at Mars, advances our understanding of Mars's radiation environment induced by large SPEs, and emphasizes the necessity of continuous and synergistic radiation monitoring at Mars.
An integrative single-cell atlas for exploring the cellular and temporal specificity of genes related to neurological disorders during human brain development
Authors: Kim Seoyeon , Lee Jihae , Koh In Gyeong , Ji Jungeun , Kim Hyun Jung , Kim Eunha , Park Jihwan , Park Jong-Eun , An Joon-Yong 
Published: October 2024

AbstractSingle-cell technologies have enhanced comprehensive knowledge regarding the human brain by facilitating an extensive transcriptomic census across diverse brain regions. Nevertheless, understanding the cellular and temporal specificity of neurological disorders remains ambiguous due to developmental variations. To address this gap, we illustrated the dynamics of disorder risk gene expression under development by integrating multiple single-cell RNA sequencing datasets. We constructed a comprehensive single-cell atlas of the developing human brain, encompassing 393,060 single cells across diverse developmental stages. Temporal analysis revealed the distinct expression patterns of disorder risk genes, including those associated with autism, highlighting their temporal regulation in different neuronal and glial lineages. We identified distinct neuronal lineages that diverged across developmental stages, each exhibiting temporal-specific expression patterns of disorder-related genes. Lineages of nonneuronal cells determined by molecular profiles also showed temporal-specific expression, indicating a link between cellular maturation and the risk of disorder. Furthermore, we explored the regulatory mechanisms involved in early brain development, revealing enriched patterns of fetal cell types associated with neuronal disorders indicative of the prenatal stage’s influence on disease determination. Our findings facilitate unbiased comparisons of cell type‒disorder associations and provide insight into dynamic alterations in risk genes during development, paving the way for a deeper understanding of neurological disorders.
PBLD promotes IRF3 mediated the type I interferon (IFN-I) response and apoptosis to inhibit viral replication
Authors: Zhu Hongchao , Hou Peili , Chu Fengyun , Li Xingyu , Zhang Wenjia , Sun Xiaonan , Liu Yu , Zhao Guimin , Gao Yuwei , He Daniel Chang , Wang Hongmei , He Hongbin 
Published: October 2024

AbstractRecent studies have implicated the phenazine biosynthesis-like domain-containing protein (PBLD) in the negative regulation of the development and progression of various cancers. However, its function in viral infection remains unknown. In this study, we found that PBLD plays important roles in multiple virus infections including BPIV3, SeV, VSV, and HSV-1. Our study revealed that PBLD enhances the expression of type I interferon (IFN-I) and ISGs through interferon regulatory factor 3 (IRF3). Further study indicated that PBLD promotes transcriptional phosphorylation of IRF3 (S385/386), thereby facilitating virus-induced IFN-I production. Interestingly, PBLD mediates virus-triggered mitochondrial apoptosis through its dependence on IRF3 (K313/315). Mechanistically, PBLD facilitated virus-induced apoptosis by recruiting the Puma protein to the mitochondria via IRF3. Additionally, we performed mutational analyses of IRF3, showing that its loss of either transcriptional or apoptotic function markedly increased viral replication. Moreover, macrophages with PBLD deficiency during viral infection exhibited decreased the IFN-I and ISGs expression, exacerbating viral infection. Importantly, mice deficient in PBLD exhibited increased viral replication and susceptibility to SeV infection, leading to decreased survival. Notably, Cedrelone, a chemical activator of PBLD, has the ability to reduce SeV replication. Collectively, we first discovered the new function of PBLD in viral infection, broadening our understanding of potential therapeutic targets and offering new insights for antiviral drug development.
TRIB3 inhibition by palbociclib sensitizes prostate cancer to ferroptosis via downregulating SOX2/SLC7A11 expression
Authors: Zhang Yangyi , Liu Chenyu , Yang Yalan , Ren He , Ren Tianyi , Huang Yinuo , Zhang Shinan , Sun Qiang , Huang Hongyan 
Published: October 2024

AbstractPalbociclib is a CDK4/6 inhibitor approved for the treatment of breast cancer by suppressing cell proliferation. However, monotherapy with palbociclib was discouraging in prostate cancer, calling for a mechanism-based effective therapy. In this study, we reported in prostate cancer that palbociclib is a potent sensitizer of ferroptosis, which is worked out by downregulating the expression of TRIB3, a gene highly expressed in prostate cancer. Specifically, TRIB3 knockdown augmented the response of prostate cancer cells to ferroptosis inducers, whereas, TRIB3 overexpression rescued prostate cancer cells from palbociclib-induced ferroptosis. Mechanistically, TRIB3 inhibition by palbociclib resulted in downregulation of SOX2, which subsequently led to compromised expression of SLC7A11, a cystine/glutamate antiporter that counteracts ferroptosis. Functionally, a combined treatment of palbociclib with ferroptosis inducer significantly suppressed prostate cancer growth in a xenograft tumor model. Together, these results uncover an essential role of TRIB3/SOX2/SLC7A11 axis in palbociclib-induced ferroptosis, suggesting palbociclib a promising targeted therapy in combine with ferroptosis induction for the treatment of prostate cancer.
Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height
Authors: Hawkes Gareth , Beaumont Robin N. , Li Zilin , Mandla Ravi , Li Xihao , Albert Christine M. , Arnett Donna K. , Ashley-Koch Allison E. , Ashrani Aneel A. , Barnes Kathleen C. , Boerwinkle Eric , Brody Jennifer A. , Carson April P. , Chami Nathalie , Chen Yii-Der Ida , Chung Mina K. , Curran Joanne E. , Darbar Dawood , Ellinor Patrick T. , Fornage Myrian , Gordeuk Victor R. , Guo Xiuqing , He Jiang , Hwu Chii-Min , Kalyani Rita R. , Kaplan Robert , Kardia Sharon L. R. , Kooperberg Charles , Loos Ruth J. F. , Lubitz Steven A. , Minster Ryan L. , Naseri Take , Viali Satupa’itea , Mitchell Braxton D. , Murabito Joanne M. , Palmer Nicholette D. , Psaty Bruce M. , Redline Susan , Shoemaker M. Benjamin , Silverman Edwin K. , Telen Marilyn J. , Weiss Scott T. , Yanek Lisa R. , Zhou Hufeng ,   NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Liu Ching-Ti , North Kari E. , Justice Anne E. , Locke Jonathan M. , Owens Nick , Murray Anna , Patel Kashyap , Frayling Timothy M. , Wright Caroline F. , Wood Andrew R. , Lin Xihong , Manning Alisa , Weedon Michael N. 
Published: October 2024

AbstractThe role of rare non-coding variation in complex human phenotypes is still largely unknown. To elucidate the impact of rare variants in regulatory elements, we performed a whole-genome sequencing association analysis for height using 333,100 individuals from three datasets: UK Biobank (N = 200,003), TOPMed (N = 87,652) and All of Us (N = 45,445). We performed rare ( < 0.1% minor-allele-frequency) single-variant and aggregate testing of non-coding variants in regulatory regions based on proximal-regulatory, intergenic-regulatory and deep-intronic annotation. We observed 29 independent variants associated with height at P < $$6\times {10}^{-10}$$
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after conditioning on previously reported variants, with effect sizes ranging from −7cm to +4.7 cm. We also identified and replicated non-coding aggregate-based associations proximal to HMGA1 containing variants associated with a 5 cm taller height and of highly-conserved variants in MIR497HG on chromosome 17. We have developed an approach for identifying non-coding rare variants in regulatory regions with large effects from whole-genome sequencing data associated with complex traits.
Neural pathways and computations that achieve stable contrast processing tuned to natural scenes
Authors: Gür Burak , Ramirez Luisa , Cornean Jacqueline , Thurn Freya , Molina-Obando Sebastian , Ramos-Traslosheros Giordano , Silies Marion 
Published: October 2024

AbstractNatural scenes are highly dynamic, challenging the reliability of visual processing. Yet, humans and many animals perform accurate visual behaviors, whereas computer vision devices struggle with rapidly changing background luminance. How does animal vision achieve this? Here, we reveal the algorithms and mechanisms of rapid luminance gain control in Drosophila, resulting in stable visual processing. We identify specific transmedullary neurons as the site of luminance gain control, which pass this property to direction-selective cells. The circuitry further involves wide-field neurons, matching computational predictions that local spatial pooling drive optimal contrast processing in natural scenes when light conditions change rapidly. Experiments and theory argue that a spatially pooled luminance signal achieves luminance gain control via divisive normalization. This process relies on shunting inhibition using the glutamate-gated chloride channel GluClα. Our work describes how the fly robustly processes visual information in dynamically changing natural scenes, a common challenge of all visual systems.