bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytochemical Characterization of the Aerial Parts of Teucrium nuchense K. Koch: An Endemic Species of Caucasian Flora
Authors: Korkotadze Teona , Berashvili Dali , Gokadze Sopio , Jokhadze Malkhaz , Bozhadze Anna , Gviniashvili Tsiala , Getia Malkhaz , Pichette André , Legault Jean , Mshvildadze Vakhtang 
Published: September 2024

Background:
The genus Teucrium L. is frequently employed in traditional medicine, primarily
for addressing disorders of the digestive and respiratory systems. Biological investigations
focused on essential oils have substantiated their antibacterial, antioxidant, anti-tumor, anti-diabetic,
and anti-rheumatic properties.

Objective:
The aim of the study was to assess the chemical composition and biological activities of
the aerial parts of the endemic species Teucrium nuchense K. Koch.

Methods:
The chemical composition of the essential oil was analyzed using gas chromatography-mass
spectrometry (GC-MS). The antioxidant activity was evaluated through the Oxygen Radical Absorbance
Capacity (ORAC) assay and tested on normal skin fibroblasts (WS-1). Additionally, the antiinflammatory
efficacy was assessed by monitoring nitric oxide production. The total phenolic content in
the aqueous, methanolic, and chloroformic extracts was quantified using the Folin-Ciocalteu reagent.
Individual compounds were isolated using preparative high-performance liquid chromatography. Their
identification was accomplished using high-resolution mass spectrometry (HRMS) with an ESI-Q-TOF
detector in conjunction with nuclear magnetic resonance (NMR) spectroscopy.

Results:
The essential oil yield was 0.32 ml/kg. Caryophyllene oxide, constituting 15.19 %, and 1-
octen-3-ol, constituting 8.75%, emerged as the primary components in the essential oil. Oxygenated
sesquiterpenes dominated the terpenic compounds, representing 25.1 % of the essential oil. The
aqueous and methanolic extracts displayed a notable phenolic content, with percentages of 27 ± 2 %
and 35 ± 0.1 %, respectively. Both the aqueous and methanolic extracts demonstrated robust antioxidant
activity in the ORAC test and in vitro assessments using WS-1 cells. The methanolic extract, at
a concentration of 160 μg/ml, inhibited NO formation by 90 %, without toxicity in RAW 264.7. Individual
compounds, teucrioside from the phenylethanoid glycoside class, two neo-clerodane diterpenes,
teucrin A, and 6-alpha-hydroxyteuscordine, were isolated.

Conclusion:
The essential oil extracted from the aerial parts of Teucrium nuchense is characterized
by the presence of caryophyllene oxide and 1-octen-3-ol. The methanolic extract exhibits notable
antioxidant as well as anti-inflammatory properties, whereas the aqueous extract demonstrates high
antioxidant activity. Additionally, three compounds of teucrioside, teucrin A, and 6-α-
hydroxyteuscordine have been isolated and characterized.
Method Development and Validation of Stability-Indicating HPLC-UV Method for Determination of 5 -Fluorouracil
Authors: Gulati Diksha , Arora Deepshi , Taneja Yugam , Dhingra Ashwani 
Published: September 2024

Introduction:
In the realm of pharmaceutical analysis, the development and validation of a High-Performance Liquid Chromatography with Ultraviolet Detection (HPLC-UV) method for the precise determination of 5-FU stand as a crucial endeavor.

Methods:
This study outlines the systematic process of method development, optimization, and subsequent validation to ensure the reliability and applicability of the method in pharmaceutical quality control. Method optimization included the selection of an appropriate stationary phase, mobile phase composition, and chromatographic conditions to achieve optimum resolution, sensi-tivity, and run time.

Results:
A speedy, simple, and dependable HPLC technique for quantifying 5-FU on a C18 (250 4.6 mm, 5m particle size) column with solvent A included 10 mM phosphate buffer with pH 3.0 and solvent B with acetonitrile as the mobile phase. At 250 nm, the effluent was measured. Fur-ther, 5-FU had a retention time of 1.698 minutes.

Conclusion:
According to ICH criteria, the devised technique was validated for precision, accu-racy, linearity range, robustness, and ruggedness.
Financial Dynamics in Cell and Gene Therapy Development: Navigating Valuation and Fundraising Challenges
Authors: Williamson Joab , Spicer Alexander , Colcomb Pierre-Albert 
Published: September 2024

:
Cell and gene therapy, offering unprecedented solutions for complex diseases, have
attracted significant attention in both the scientific and financial communities. This article
explores the tumultuous financial journey of companies specializing in these advanced therapeutic
modalities. The discussion illuminates the volatility of share prices, challenges in
valuation, and complexities in fundraising while delving into the inherent risks of the cell and
gene therapy development pathway. Through an examination of various strategies, the article
underscores the importance of diverse investment sources, robust collaborations, risk-sharing
models, and portfolio diversification in ensuring financial stability. As the field burgeons, understanding
these financial dynamics is paramount for stakeholders aiming to harness the
transformative potential of cell and gene therapies.
ANALISIS PENGARUH JUMLAH PENDUDUK, PRODUK DOMESTIK REGIONAL BRUTO (PDRB), INFLASI DAN JUMLAH TENAGA KERJA TERHADAP PENDAPATAN ASLI DAERAH (PAD) KOTA MALANG TAHUN 2012-2021
Authors: Surya Andriansyah Afwanda , Moh. Athoillah  
Published: September 2024

This study aims to determine the effect of total population, Gross Regional Domestic Product (GDP), inflation and total employment to Region Own-Source Revenue (PAD) in 2012-2021. This study used qualitative approach and literature review method. The data were obtained from Central Bureau of Statistics and the annual financial reports of Malang City through the official website which can be accessed by the public. The results of this study indicated that the variables of total population, inflation and total employment do not have a significant influence on Region Own-Source Revenue (PAD). However, Gross Regional Domestic Product (GDP) has a positive and significant influence on Region Own-Source Revenue (PAD). Meanwhile, total population, Gross Regional Domestic Product (GDP), inflation and total employment have a simultaneous influence of 96,4% on Region Own-Source Revenue (PAD).
Toward Personalized Care and Patient Empowerment and Perspectives on a Personal Health Record in Hemophilia Care: Qualitative Interview Study
Authors: Brands Martijn R , Haverman Lotte , Muis Jelmer J , Driessens Mariëtte H E , Meijer Stephan , van der Meer Felix J M , de Jong Marianne , van der Bom Johanna G , Cnossen Marjon H , Fijnvandraat Karin , Gouw Samantha C 
Published: September 2024

Background
To enable personalized treatment and shared decision-making in chronic care, relevant health information is collected. However, health information is often fragmented across hospital information systems, digital health apps, and questionnaire portals. This also pertains to hemophilia care, in which scattered information hampers integrated care. We intend to co-design a nationwide digital personal health record (PHR) for patients to help manage their health information. For this, user perspectives are crucial.

Objective
This study aims to assess patients’ and health care providers’ perspectives regarding the use of a PHR in hemophilia care in the Netherlands, required functionalities, and expectations and concerns.

Methods
In this semistructured interview study, 19 pediatric and adult persons with hemophilia, parents, and women with other inherited bleeding disorders, as well as 18 health care providers working within and outside of hemophilia treatment centers, participated. Perspectives of patients and providers were explored separately. To explore requirements, participants were asked to prioritize functionalities.

Results
Participants expected a PHR would increase the transparency of health information, improve patients’ understanding of their illness, and help the coordination of care between health care providers and institutions. Prioritized functionalities included the integration of relevant health information and patient-entered data. Formulated expectations and concerns focused on 4 themes: usability, safety, inclusiveness, and implementation. While patients expressed worries over medicalization (ie, more confrontational reminders of their illness), providers were concerned about an increased workload.

Conclusions
People with hemophilia, their parents, and health care providers welcomed the development of a PHR, as they expected it would result in better coordinated care. Formulated expectations and concerns will contribute to the successful development of a PHR for persons with hemophilia, and ultimately, for all persons with a chronic condition.
Role of Synchronous, Moderated, and Anonymous Peer Support Chats on Reducing Momentary Loneliness in Older Adults: Retrospective Observational Study
Authors: Dana Zara , Nagra Harpreet , Kilby Kimberly 
Published: September 2024

Background
Older adults have a high rate of loneliness, which contributes to increased psychosocial risk, medical morbidity, and mortality. Digital emotional support interventions provide a convenient and rapid avenue for additional support. Digital peer support interventions for emotional struggles contrast the usual provider-based clinical care models because they offer more accessible, direct support for empowerment, highlighting the users’ autonomy, competence, and relatedness.

Objective
This study aims to examine a novel anonymous and synchronous peer-to-peer digital chat service facilitated by trained human moderators. The experience of a cohort of 699 adults aged ≥65 years was analyzed to determine (1) if participation, alone, led to measurable aggregate change in momentary loneliness and optimism and (2) the impact of peers on momentary loneliness and optimism.

Methods
Participants were each prompted with a single question: “What’s your struggle?” Using a proprietary artificial intelligence model, the free-text response automatched the respondent based on their self-expressed emotional struggle to peers and a chat moderator. Exchanged messages were analyzed to quantitatively measure the change in momentary loneliness and optimism using a third-party, public, natural language processing model (GPT-4 [OpenAI]). The sentiment change analysis was initially performed at the individual level and then averaged across all users with similar emotion types to produce a statistically significant (P<.05) collective trend per emotion. To evaluate the peer impact on momentary loneliness and optimism, we performed propensity matching to align the moderator+single user and moderator+small group chat cohorts and then compare the emotion trends between the matched cohorts.

Results
Loneliness and optimism trends significantly improved after 8 (P=.02) to 9 minutes (P=.03) into the chat. We observed a significant improvement in the momentary loneliness and optimism trends between the moderator+small group compared to the moderator+single user chat cohort after 19 (P=.049) and 21 minutes (P=.04) for optimism and loneliness, respectively.

Conclusions
Chat-based peer support may be a viable intervention to help address momentary loneliness in older adults and present an alternative to traditional care. The promising results support the need for further study to expand the evidence for such cost-effective options.
Implementation of Artificial Intelligence–Based Diabetic Retinopathy Screening in a Tertiary Care Hospital in Quebec: Prospective Validation Study
Authors: Antaki Fares , Hammana Imane , Tessier Marie-Catherine , Boucher Andrée , David Jetté Maud Laurence , Beauchemin Catherine , Hammamji Karim , Ong Ariel Yuhan , Rhéaume Marc-André , Gauthier Danny , Harissi-Dagher Mona , Keane Pearse A , Pomp Alfons 
Published: September 2024

Background
Diabetic retinopathy (DR) affects about 25% of people with diabetes in Canada. Early detection of DR is essential for preventing vision loss.

Objective
We evaluated the real-world performance of an artificial intelligence (AI) system that analyzes fundus images for DR screening in a Quebec tertiary care center.

Methods
We prospectively recruited adult patients with diabetes at the Centre hospitalier de l’Université de Montréal (CHUM) in Montreal, Quebec, Canada. Patients underwent dual-pathway screening: first by the Computer Assisted Retinal Analysis (CARA) AI system (index test), then by standard ophthalmological examination (reference standard). We measured the AI system's sensitivity and specificity for detecting referable disease at the patient level, along with its performance for detecting any retinopathy and diabetic macular edema (DME) at the eye level, and potential cost savings.

Results
This study included 115 patients. CARA demonstrated a sensitivity of 87.5% (95% CI 71.9-95.0) and specificity of 66.2% (95% CI 54.3-76.3) for detecting referable disease at the patient level. For any retinopathy detection at the eye level, CARA showed 88.2% sensitivity (95% CI 76.6-94.5) and 71.4% specificity (95% CI 63.7-78.1). For DME detection, CARA had 100% sensitivity (95% CI 64.6-100) and 81.9% specificity (95% CI 75.6-86.8). Potential yearly savings from implementing CARA at the CHUM were estimated at CAD $245,635 (US $177,643.23, as of July 26, 2024) considering 5000 patients with diabetes.

Conclusions
Our study indicates that integrating a semiautomated AI system for DR screening demonstrates high sensitivity for detecting referable disease in a real-world setting. This system has the potential to improve screening efficiency and reduce costs at the CHUM, but more work is needed to validate it.
Use of antibiotics among small-scale cattle farmers in rural areas in Queretaro, Mexico
Authors: Galarde-López Miguel , Cruz-Monsalvo Brenda Yoselin , Velazquez-Meza Maria Elena , Carranza-Velázquez José Alfredo , Zumaya-Estrada Federico Alonso , Carrillo-Quiroz Berta Alicia , Herrera-García Sara Claudia , Alpuche-Aranda Celia Mercedes 
Published: September 2024

The inappropriate use of antibiotics in the livestock sector has been described as one of the causes of the emergence of antimicrobial resistance. Information on antibiotic use in small-scale farms is limited. Our objective was to identify patterns of antibiotic use in small-scale cattle farms in Queretaro, Mexico. Cross-sectional study with 50 small-scale cattle farmers from rural areas surveyed in the municipality of Tequisquiapan, Queretaro between May–October 2022. Convenience sampling, non-probabilistic, small-scale cattle farms were selected using respondent-driven sampling methodology. A face-to-face survey was applied, structured in five sections: i) small-scale cattle farmers´ profile, ii) characteristics of small-scale cattle farms, iii) antibiotic use, iv) antibiotic prescription, and v) inventory of stored antibiotics vials. The data collected were processed and analyzed. Ninety-two percent of the small-scale cattle farmers were male, with an age range of 23 to 88 years (median 58.5, IQR 49–64.5). Seventy-four percent of the small-scale cattle farmers had a basic level of schooling. The animal census consisted of 968 animals. A total of 142 stored antibacterial products from nine antibiotic classes were recorded: 34.5 % were penicillin, 19 % oxytetracycline, 13.4 % gentamicin, 9.8 % florfenicol, and 8.4 %enrofloxacin. About 50 % of the stored antibiotics have a "watch" classification in the WHO AWaRe tool. Seventy-eight percent of small-scale cattle farmers throw empty antibiotic vials in the trash. Our study showed that small-scale cattle farmers had an important use of third generation cephalosporins, tetracyclines, and fluoroquinolones; antibiotics considered “watch” by the WHO.
Three-dimensional assessment of the nasopharyngeal airway in Down syndrome during the mixed dentition period: a case-control study
Authors: Takizawa Hideomi , Takahashi Masahiro , Yoshida Hiroshi , Yamaguchi Tetsutaro , Maki Koutaro 
Published: September 2024

ABSTRACT

Objective
In this retrospective case-control study, we aimed to evaluate the nasopharyngeal airway volume of children with Down syndrome (DS) and compare the results with those of control participants well matched for sex and age.

Materials and Methods
Fifteen children with DS (mean age = 9.43 ± 0.38 years; 8 boys, 7 girls) and 15 control participants (mean age = 9.51 ± 0.40 years; 8 boys, 7 girls) were enrolled. The nasopharyngeal airway volume and the cross-sectional morphology were measured with cone-beam computed tomography taken for orthodontic treatment. All measurements were assessed by analysis of covariance (ANCOVA) using Bonferroni post hoc pairwise comparison tests. Covariates were body height and body weight, and the ANB angle and the mandibular plane angle. Significance was set at P &lt; .0019.

Results
Nasal airway, superior airway, and total airway volumes of DS participants were significantly smaller than those of the control participants in ANCOVA results adjusted for ANB angle and mandibular plane angle (P = .000). In ANCOVA results adjusted for body height and body weight, no statistically significant differences in the volume measurements were found.

Conclusion
The results indicate that the nasopharyngeal airway volume differs between children with and without DS and that the airway volume tends to be smaller in DS children than in children without DS.
The Effects of Music Therapy on Patients with Coronary Artery Disease after the Invasive Procedure: A Systematic Review and Meta-Analysis
Authors: Munawaroh Meihati , Setyawati Anita , Udin Ihwanudin , Novianti Rika Astri 
Published: September 2024

Latar Belakang. Penyakit arteri koroner (CAD) sebagai penyebab nyeri merupakan salah satu masalah kesehatan yang harus menjadi perhatian, baik di kawasan Barat maupun di dunia pada umumnya. Dengan seringnya melakukan pemantauan terhadap peralatan kesehatan, tidak adanya dukungan keluarga, dan kekhawatiran akan keberhasilan operasi, pasien mudah merasa cemas dan nyeri setelah menjalani prosedur. Terapi musik dapat menawarkan teknik komunikasi bagi individu yang tidak mampu mengekspresikan dirinya secara verbal.Objektif. Meta-analisis ini bertujuan untuk mengetahui efek terapi musik untuk menghilangkan nyeri pada pasien penyakit arteri koroner pasca prosedur invasif.Metode. Tinjauan saat ini dilakukan dan dipandu oleh item pelaporan yang disukai untuk Tinjauan Sistematis dan Meta-Analisis (PRISMA). Dengan menggunakan keywords: "coronary disease", "music therapy", dan "pain" yang dikombinasikan menggunakan operator boolean. Pencarian literatur dilakukan secara komprehensif pada dua basis data yaitu PubMed dan ProQuest.Hasil. Studi yang disertakan dalam penelitian ini terbit antara tahun 2011 hingga 2024. Studi dilakukan di tiga negara berbeda yaitu Turki, Tiongkok, dan Eropa. Dari penelitian yang disertakan ini, sebanyak 382 peserta dilibatkan, 191 di kelompok eksperimen dan 191 dikelompokkan kontrol. Kisaran ukuran sampel pada setiap penelitian bervariasi antara 31 hingga 94 responden.Implikasi Klinis. Studi ini dapat dijadikan sebagai bahan penelitian lebih lanjut untuk mengonfirmasi penelitian ini. Selain itu, studi ini dapat dijadikan pengembangan klinis tentang bagaimana terapi musik berintegrasi dengan berbagai intervensi medis untuk meningkatkan kualitas pelayanan kesehatan.Kata Kunci. penyakit arteri koroner, terapi musik, nyeri
Assessment of the Applicability of Lora Technology in Smart Metering
Authors: Волошин Е.В. 
Published: September 2024

Рассмотрен вопрос применения технологии Lora для взаимодействия с современными электросчетчиками. Даны предпосылки применения, компоненты и возможности технологии Lora. Описана тестовая система учета и ее компоненты для проверки возможностей технологии Lora. Перечислены выявленные в процессе эксплуатации технологии Lora особенности, на основании которых делаются выводы о возможности применения технологии Lora для интеллектуального учета.
The question of the application of Lora technology for interaction with modern electric meters is considered. The application prerequisites, components and capabilities of Lora technology are given. The test accounting system and its components for testing the capabilities of Lora technology are described. The features identified during the operation of Lora technology are listed, based on which conclusions are drawn about the possibility of using Lora technology for intelligent metering.
Transformation of Parametric Structural Schemes of Electroelastic Actuator for Nanomechatronics
Authors: Афонин С.М. 
Published: September 2024

В данной статье построены параметрические структурные схемы электроупругого актюатора, определена матричная передаточная функция электроупругого актюатора, рассчитаны динамические характеристики электроупругого актюатора для наномеханики. Используются уравнения электроупругости для нахождения характеристик электромеханических актюаторов, работающих на основе пьезоэлектрического или электрострикционного эффектов. С использованием решения линейного обыкновенного дифференциального уравнения второго порядка определена система уравнений, описывающая математическую модель актюатора для наномеханики. Из математической модели электроупругого актюатора получена матричная передаточная функция актюатора. Рассчитанные характеристики электроупругого актюатора позволяют выбирать его параметры в зависимости от нагрузки. Электроупругий актюатор на основе пьезоэлектрического или электрострикционного эффекта применяется в нанотехнологии, микроэлектроникe, нанобиологии, адаптивной оптике, лазерных системах, зондовой микроскопии для совмещении и сканировании в наномехатронных системах. Определена параметрическая структурная схема электроупругого актюатора для наномехатроники с учетом противоэлектродвижущей силы из-за прямого пьезоэффекта. Получена параметрическая структурная схема с обратными связями для электроупругого актюатора для наномехатроники, отображающая преобразование электрической энергии в механическую энергию актюатора.
In this article, the parametric structural schemes of the electroelastic actuator are constructed, the matrix transfer function of the electroelastic actuator is determined, and the dynamic characteristics of the electroelastic actuator for nanomechanics are calculated. Electroelasticity equations are used to find the characteristics of electromechanical actuators operating on the basis of piezoelectric or electrostrictive effects. Using a solution of the linear ordinary differential equation of the second order, the system of equations is determined that describes the mathematical model of the actuator for nanomechanics. The matrix transfer function of the actuator is obtained from the mathematical model of the electroelastic actuator. The calculated characteristics of the electroelastic actuator make it possible to choose its parameters depending on the load. An electroelastic actuator based on the piezoelectric or electrostrictive effect is used in nanotechnology, microelectronics, nanobiology, adaptive optics, laser systems, probe microscopy for combining and scanning in nanomechatronic systems. The parametric structural scheme of the electroelastic actuator for nanomechatronics is determined taking into account the antielectromotive force due to the direct piezoelectric effect. The parametric structural scheme with feedbacks has been obtained for an electroelastic actuator for nanomechatronics, which displays the conversion of electrical energy into mechanical energy of the actuator.