bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statistical issues in pragmatic trials of behavioral economic interventions
Authors: Troxel Andrea B , Asch David A , Volpp Kevin G 
Published: July 2016

Background: Randomized clinical trials provide gold-standard evidence for the efficacy of interventions, but have limitations, including highly selected populations that make inference on effectiveness difficult and a lack of ability to adapt and change midstream. Methods: We propose two innovations for pragmatic trial design. Results: Evidence-based evolutionary testing, a framework that allows adaptation of interventions and rapid-cycle innovation, preserves the power of randomization while acknowledging the need for adaptation and learning. An opt-out consent framework increases the fraction of the target population who participate in trials, but may lead to dampening of effect sizes. Conclusion: Pragmatic trials offer numerous advantages in the evaluation of behavioral interventions in health. Statistical innovations, including evidence-based evolutionary testing and opt-out framing of consent and enrollment processes, can enhance the power of pragmatic trials and lead to more rapid progress.
Patient-reported outcomes questionnaire compliance in Cancer Cooperative Group Trials (Alliance N0992)
Authors: Atherton Pamela J , Burger Kelli N , Pederson Levi D , Kaggal Suneetha , Sloan Jeff A 
Published: July 2016

Background/Aims: The use of patient-reported outcomes in clinical trials is a focal point for research and policy. Non-compliance with planned questionnaires and missing data can threaten both internal validity and generalizability. This retrospective analysis was conducted to determine the extent of, and characteristics associated with, missing patient-reported outcomes. Methods: Study characteristics, patient characteristics and adverse events, and reasons for non-compliance were compiled from 14 closed Alliance for Clinical Trials in Oncology, Mayo Clinic Cancer Center, or Mayo Clinic Cancer Research Consortium clinical trials. Compliance rates were calculated for each patient using the number of booklets completed while the patient was on trial divided by the number of booklets the patient was expected to complete. Frequency counts and summary statistics were compiled. Logistic regression techniques were employed. Results: The 1640 included patients had a median age of 58 years and were mostly White (90.8%) and female (73.8%). Compliance rates per study ranged from 84.7% to 97.2%. The primary endpoint of overall compliance rate was 93.1%. A total of 1267 patients were compliant. Those non-compliant were slightly older (mean = 58.6 vs 57.5, p = 0.03) and had different types of cancers (p < 0.01). There were no differences in compliance according to tumor status (p = 0.66), clinical stage (p = 0.81), baseline quality of life (p = 0.42 for ≥8 vs <8 and p = 0.12 for ≥6 vs <6), or maximum adverse event grade incidence (p = 0.33 for grade 2+ incidence and p = 0.36 for grade 3+ incidence). Reasons for non-compliance included patient refusal (N = 136), booklet not administered to patient (N = 199), no clinic visit at the scheduled time for booklet completion (N = 40), and at-home-completed booklet not returned (N = 224). Logistic regression indicates gender (p < 0.01), race (p < 0.01), performance score (p = 0.02), dose delay status (p = 0.01), and incidence of grade 3 or higher adverse event (p = 0.03) were correlates of compliance. Conclusion: Patient-reported outcomes have successfully been implemented into Alliance and Mayo Clinic trials with high rates of patient compliance. Further improvement in compliance can be made with staff commitment and education. Patients are typically non-compliant only when the task at hand is burdensome, unclear, or logistically challenging. Existing tracking systems used for the other trial outcomes should be utilized to ensure successful capture of patient-reported outcomes.
Ketamine: a novel antidepressant with a fast onset of action?
Authors: Smith Katharine , Attenburrow Mary Jane 
Published: July 2016

SummaryGlutamate receptor modulators, including ketamine, are possible candidates for new antidepressants with a novel mode of action. The pair of reviews discussed in this month's Round the Corner considered their use in treating unipolar major depression and bipolar depression. Promising results were seen for ketamine, but further studies are needed, in particular to investigate whether the benefits are sustained or can be extended by repeated or adjunctive treatment, whether ketamine is effective in treatment resistance, whether other modes of administration are as effective as the intravenous route and the long-term adverse effects of use.
Insecticide Dip Treatments to Prevent Walnut Twig Beetle Colonization of Black Walnut Logs
Authors: Audley Jackson , Taylor Adam , Klingeman William E. , Mayfield Albert E. , Myers Scott W. 
Published: July 2016

Abstract
The health, sustainability, and commercial viability of eastern black walnut (Juglans nigra) are currently under threat from thousand cankers disease. The disease is caused by an invasive bark beetle species, the walnut twig beetle (Pityophthorus juglandis), and its associated fungal pathogen (Geosmithia morbida). Range expansion of the beetle and pathogen has likely been facilitated by transport of infested walnut forest products. Preventing colonization of these products is crucial to limiting further spread of thousand cankers disease. This study evaluated three insecticides for their ability to induce walnut twig beetle mortality and prevent colonization of black walnut bolts, 3 to 5 cm in diameter, after dip treatment applications. Treatments included 0.003 percent azadirachtin, 15 percent disodium octaborate tetrahydrate (DOT), 0.5 percent permethrin, and water in Trial 1, and 0.013 percent azadirachtin, 30 percent DOT, 0.5 percent permethrin, and water in Trial 2. A total of 40 beetles, 4 beetles per sample, were exposed to treated samples and observed for 120 hours in each trial. Permethrin was the only treatment to achieve 100 percent mortality and prevent all colonization activity. The 30 percent DOT treatment increased mortality compared with the control; however, it did not reduce the mean number of attacks or mean gallery length. Azadirachtin was not effective at either concentration. Results suggest that insecticide dip treatments can prevent walnut twig beetles from colonizing cut black walnut logs. Treatments could be used in conjunction with phytosanitation to help prevent further spread of thousand cankers disease while allowing for the continued transport of bark-on walnut forest products.
Not Even in a Dream. Emigration and immigration in new Italian cinema
Authors: Zagarrio Vito 
Published: July 2016

Abstract
After a historical and theoretical review, this article analyses several generations of film-makers whose works address the phenomena of emigration and immigration as represented in Italian cinema. The classic, post-war Italian cinema often describes emigration from the country, but in the last two decades, new Italian cinema has dealt with the topic of immigration in its diverse and complex forms. More specifically, the discussion will focus on the generation of the post-fascist Italy (Germi, De Seta), the ‘modern’ Italian film-makers (such as Bertolucci), the auteurs of the 1980s and 1990s (Tornatore, Giordana, Amelio) and lastly the generation of the New Italian Cinema of the 2000s (Crialese, Segre, Mazzacurati, Salani, Noce, Di Matteo, Munzi, Cupellini, Giovannesi among others).
Consideration of Marital Status in a Mortality Model and its Application for Mortality Risk Management
Authors: Kwon Hyuk-Sung 
Published: July 2016

Abstract
As a variety of mortality risk factors have been identified by previous studies, it is desirable that these factors are reflected in mortality (longevity) risk assessments for life insurance, individual annuities, and pension plans. In this study, an extended traditional mortality table that accommodates marital status, which is one of the important risk factors in terms of mortality, is considered. A logistic regression method is used to model the mortality of groups of people with four different marital statuses–never married, married, widowed, and divorced. The analyses are based on data regarding mortality and changes of marital status in Korea. The results of the analyses that are based on the developed mortality model suggest that the information on risk factors must be reflected in an actuarial model to improve the evaluations and monitoring of risk for the portfolios of relevant insurance products.
The annexin A2 system and angiogenesis
Authors: Liu Wei , Hajjar Katherine A. 
Published: July 2016

AbstractThe formation of new blood vessels from pre-existing vasculature, the process known as angiogenesis, is highly regulated by pro- and anti-angiogenic signaling molecules including growth factors and proteases. As an endothelial cell-surface co-receptor for plasminogen and tissue plasminogen activator, the annexin A2 (ANXA2) complex accelerates plasmin generation and facilitates fibrinolysis. Plasmin can subsequently activate a downstream proteolytic cascade involving multiple matrix metalloproteinases. Thus, in addition to maintaining blood vessel patency, the ANXA2 complex can also promote angiogenesis via its pro-fibrinolytic activity. The generation of ANXA2-deficient mice allowed us to first observe the pro-angiogenic role of ANXA2in vivo. Further investigations have provided additional details regarding the mechanism for ANXA2 regulation of retinal and corneal angiogenesis. Other studies have reported that ANXA2 supports angiogenesis in specific tumor-related settings. Here, we summarize results fromin vivostudies that illustrate the pro-angiogenic role of ANXA2, and discuss the critical questions that may lead to an advanced understanding of the molecular mechanisms for ANXA2-mediated angiogenesis. Finally, highlights from studies on ANXA2-interacting agents offer potential therapeutic opportunities for the application of ANXA2-centered pharmaceuticals in angiogenesis-related disorders.
Characterizing Structural Performance of Unbound Pavement Materials Using Miniaturized Pressuremeter and California Bearing Ratio Tests
Authors: Shaban A. M. , Cosentino P. J. 
Published: July 2016

Abstract
Comparative analyses were implemented between the miniaturized pressuremeter (MPMT) test and the California bearing ratio (CBR) test to assess the capability of the MPMT stress-strain data for predicting structural performance of unbound pavement layers. Fifty-four MPMT tests and 108 CBR tests were performed on both base and subgrade soils in Brevard County, Florida. These comparative analyses were conducted in two stages. First, statistical correlations were established by comparing MPMT parameters with structural coefficients and structural numbers obtained from CBR data and the corresponding correlations. The results indicated that initial elastic moduli and limit pressures from MPMT correlate well with structural coefficients and structural numbers. Comparing them with results reported by AASHTO validated the quality of the correlation models. Secondly, finite element analyses were carried out to predict CBR as a function of MPMT data reduced to the strain-level model. The elastic moduli from the MPMT strain level model were input into the finite element simulation. To capture actual soil behavior, six strain levels were utilized during numerical simulations. For base course materials, strain evaluation points were selected at the top, middle, and bottom of the layer. For subgrade soils, strain evaluation points were selected at the top of the subgrade, 15 cm and 30 cm below subgrade surface. The results indicate that strain level moduli at the top of the base course layers provide the best CBR estimation, with the ratio of finite element CBR to measured CBR equal to 0.91. The results of subgrade show that strain level moduli determined at the depth of 15 cm below subgrade surface yield the best CBR prediction. The ratio of finite element CBR to measured CBR was 1.00.
The Material Dispatching Method for Conveyor System in 450 mm Wafer Fabrication
Authors: Wang C.-N. , Chung Y.-T. , Wang Y.-H. , Duong M.-T. , Lin T.-F. 
Published: July 2016

Abstract
The transition to 450 mm wafer manufacturing has already become a development trend for the semiconductor industry. To handle the larger wafer size, the conveyor-based automated material handling system (AMHS) is considered as the next-generation transportation. However, there is not any effective method for handling prioritized lots for 450 mm conveyor-based AMHS. This study developed an effective dispatching method named the “conveyor preemptive dispatching” (CPD) method for conveyor-based AMHS to minimize the average variable time of hot lots with the minimum impact to the transport of normal lots. Experiment results revealed that the CPD demonstrates better performance than the existing method. The CPD method reduced the average variable time by 59 % (from 14.572 to 5.904 s) for hot lots and 31 % (from 3962.394 to 2741.889 s) for normal lots. It expedites the movement of lots and significantly reduces lot average variable time and will effectively enhance the throughput of lots transportation.
TIC en el curriculo de matemáticas. Una orientación desde el marco de las politicas y proyectos educativos
Authors: Arévalo Duarte Mayra , Gamboa Suárez Audin 
Published: July 2016

<div data-canvas-width="1093.9928016262456">El presente artículo muestra una reflexión sobre los criterios que orientarán la inte</div><div>-</div><div data-canvas-width="1115.2507879124284">gración de las TIC en el currículo de matemáticas desde el marco de las políticas</div><div data-canvas-width="1114.5127293809603">y proyectos educativos TIC desarrollados en el territorio colombiano. El análisis se</div><div data-canvas-width="1093.9199460630537">desarrolló a partir de la identificación de fuentes primarias y secundarias de información, la fundamentación del sistema de categorías y el diseño del instrumento</div><div data-canvas-width="1115.342649274714">para la organización y sistematización de la información. Los resultados producto</div><div data-canvas-width="1114.4968912150491">del proceso de análisis de estas fuentes configuran algunos aspectos para orientar <div data-canvas-width="668.4364882281745">Mayra Alejandra Arévalo Duarte, Audin Aloiso Gamboa Suárez</div><div data-canvas-width="530.6773881847283">Universidad Santo Tomás, Facultad de Educación</div><div data-canvas-width="48.62633698095498">170</div><div data-canvas-width="1115.0195506901227">la integración de las TIC en el currículo de matemáticas. Finalmente, se concluye</div><div data-canvas-width="1094.0276455912508">que las políticas y proyectos desarrollados en torno a las TIC son un insumo fun</div><div>-</div><div data-canvas-width="1114.5760820446058">damental para construir las bases teóricas y metodológicas de la incorporación de</div><div data-canvas-width="1115.3078053097088">las TIC en el sistema educativo, y para caracterizar el contexto que le permitirá a</div><div data-canvas-width="1118.1333341082898">las instituciones educativas comprender las exigencias del Estado y la sociedad</div><div data-canvas-width="1116.6730552112651">para plantear currículos pertinentes y viables según las metas y propósitos de la</div><div data-canvas-width="332.0946628286965">educación en Colombia.</div></div>
Evaluación de la accesibilidad a la información de las personas con discapacidad visual en los sitios web de los ministerios de Costa Rica
Authors: Rodríguez Segura Natalia 
Published: July 2016

Para facilitarles el acceso a la información a las personas con discapacidad se han creado normas internacionales que regulan el contenido hallado en las páginas de Internet. Ejemplo de ello, son las Pautas de Accesibilidad para el Contenido Web 2.0, desarrolladas por el Consorcio World Wide (W3C) y como parte de la Iniciativa de Accesibilidad Web. Dichas pautas promueven la accesibilidad, ayudando a queel contenido web sea más útil tanto para las personas con algún tipo de discapacidad como para aquellas que bajo otras circunstancias encuentren dificultades para obtener el acceso a la información de los sitios web. El presente trabajo pretende determinar el grado de accesibilidad que poseen los sitios web de los ministerios costarricenses hacia las personas con discapacidad visual de nuestro país, tomando en cuenta herramientas como TAW, que es un instrumento basado en las Pautas de Accesibilidad al Contenido Web.
Notes and description amendment of Telipogon phuyupatamarcensis (Orchidaceae)
Authors: Collantes Benjamin , Martel Carlos 
Published: July 2016

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>Telipogon phuyupatamarcensis </span><span>es una especie poco conocida y endémica de Perú. Especímenes vivos </span><span>de diversas poblaciones fueron revisadas. Se proveen una descripción actualizada, ilustraciones, figuras y notas </span><span>taxonómicas. </span></p></div></div></div>
Scaffold degradation during bone tissue reconstruction in Macaca nemestrina mandible
Authors: Bachtiar Endang W. , Amir Lisa Rinanda , Suhardi Pradono , Abas Basril 
Published: July 2016

Objective
To examine the degradation of three scaffolds composed of hydroxyapatite/tricalcium phosphate (HA/TCP) with 70∶30 ratio, HA/TCP with 50∶50 ratio, and HA/TCP/chitosan scaffold as analyzed by the RNA expression of matrix metalloprotease 2 (MMP2), interleukin 13 (IL13), and tartrate-resistant acid phosphatase (TRAP) genes.

Methods
The three tested scaffolds and dental pulp stromal cells (DPSCs) were transplanted into the mandibular bone defect of six young male Macaca nemestrina. Defect on the left mandible served as the experimental group and the right mandible served as control group (split mouth design). The biopsies were retrieved at 0, 2, and 4 weeks after cell-scaffold transplantation. The expression of MMP2, IL13, and TRAP was analyzed by real-time PCR (RT-PCR).

Results
The inflammatory cells were still detected in areas where active bone and blood vessel formation occurred. The remnants of scaffold biomaterials were rarely seen. The expression of MMP2, IL13, and TRAP was observed in all samples. Their expressions were increased at week 4 and the decrease of TRAP gene expression in the experimental group was found higher than the control group. TRAP gene in the HA/TCP/chitosan group was found to be the highest at week 2 and lowest at week 4.

Conclusions
Degradation of the scaffold did not induce higher inflammatory response compared to the control yet it induced more osteoclast activity.
Anxiety, Gambling Activity, and Neurocognition: A Dimensional Approach to a Non-Treatment-Seeking Sample
Authors: Medeiros Gustavo C. , Sampaio Daniela G. , Leppink Eric W. , Chamberlain Samuel R. , Grant Jon E. 
Published: July 2016

Background and aims
Previous analyses have highlighted significant associations between gambling disorder (GD)/subsyndromal GD and increased rates of anxiety symptoms and anxiety disorders relative to the general population. However, less is known about how anxiety symptoms influence the clinical presentation of gambling problems. The objective of this study was to evaluate the association between anxiety symptoms, gambling activity, and neurocognition across the spectrum of gambling behavior.

Methods
The sample consisted of 143 non-treatment-seeking young adults (aged 18–29 years), in which 63 individuals (44.1%) were classified as recreational gamblers, 47 (32.9%) as having subsyndromal GD, and 33 (23.1%) met criteria for GD.

Results
The main findings were: (a) there was a positive correlation between anxiety severity and gambling severity measured by the number of DSM-5 GD criteria met; (b) there was a positive correlation between anxiety severity and attentional impulsiveness; (c) subjects with suicidality presented higher levels of anxiety; and (d) the severity of anxiety symptoms was negatively correlated with the quality of life.

Discussion and conclusions
This study suggests that anxiety may be associated with relevant clinical variables in the broad spectrum of gambling activity. Therefore, proper management of anxiety symptoms might improve the clinical presentation of gamblers in different areas.
"Ett universum av tecken” Intertextuella relationer i femton svenska recensioner av Michel Houellebecqs Underkastelse
Authors: Larsson Erik 
Published: July 2016

Målet med artikeln har varit att svara på de frågeställningar som formulerades inledningsvis. Gällande vilken funktion de intertextuella referenserna har i den kritiska texten är svaret att det är högst varierande. Den historiskt-genetiska intertexten har som namnet anger en i första hand förklarande funktion, det vill säga att hävda något slags kausalitet. Därtill kommer de rent illustrativa intertexterna, vilka har visat sig kunna användas i en rad olika syften: för att jämföra, för att beskriva, för att värdera, för att kategorisera samt för att kontextualisera. Sammantaget har alltså sex huvudsakliga användningsområdenkunnat urskiljas. Gällande artikelns tredje frågeställning kan konstateras att det recensionsmaterialet i allra högsta grad gör att finna stöd för de intertextuella relationer som enligt Riffaterre karakteriserar den litteraturkritiska diskursen.
IRMÃOS DE CRIANÇAS COM PERTURBAÇÃO DO ESPETRO DO AUTISMO
Authors: Pereira Garcia Galvão Dulce Maria , Dos Santos Leonardo Ana Patricia 
Published: July 2016

As Perturbações do Espetro do Autismo (PEA) afetam a interação, comunicação e comportamento de uma criança, alterando profundamente o ambiente familiar.Objetivos: Conhecer a experiência vivida dos irmãos de crianças com PEA.Participantes e Métodos: Estudo descritivo exploratório, de natureza qualitativa, junto de 11 irmãos de crianças com PEA, através de entrevista semiestruturada, realizada em Outubro e Novembro/2013, e análise de dados proposta por Bardin.Resultados: Emergiram quatro temas: a criança e o diagnóstico de doença do irmão, a criança e o irmão com PEA, a criança e os pais e a criança e os outros.Conclusões: Ser irmão de uma criança com PEA é uma experiência única, contudo apresenta aspetos positivos e negativos, sendo a atenção dispensada pelos pais uma das maiores necessidades sentidas pelos irmãos de crianças com PEA. Com base nos resultados obtidos, a intervenção dos enfermeiros junto dos irmãos poderão clarificar as necessidades sentidas, bem como intervir junto dos pais alertando-os que a atenção por eles dispensada aos filhos é uma das grandes necessidades verbalizadas pelas crianças.
Credibilidade das redes sociais online: aos olhos dos jornalistas profissionais finlandeses
Authors: Hasnat Mohammad Ofiul 
Published: July 2016

Este artigo analisa a alteração da estrutura de apresentação de notícias nas redes sociais, abordando as questões de credibilidade e de ética. Destaca os importantes fatores de precisão e de confiança, como forma de avaliar a relevância noticiosa e a credibilidade das notícias nas redes sociais. Têm emergido possíveis ideias de edição de conteúdos nas redes sociais, uma vez que a ausência de um processo de moderação tem levantado dúvidas acerca da credibilidade das redes sociais. Este estudo analisa o conteúdo de entrevistas temáticas realizadas com jornalistas profissionais selecionados, de quatro jornais diferentes: Lapin Kansa, Kaleva, Keskipohjanmaa e Österbottens Tidning, na Finlândia. Os resultados mostram que as redes sociais começaram a cumprir o objetivo de fazer chegar as notícias às pessoas e que estas redes irão emergir como media de pleno direito, no futuro, desde que a autenticidade, a credibilidade e a transparência da informação e da ética jornalística sejam asseguradas.