bluuebunny/crossref_metadata_2025_split huggingface dataset:
Der Schiedsspruch zum Südchinesischen Meer und die Reaktionen Beijings
Authors: Mohr Johannes 
Published: June 2017

Kurzfassung:
Das 2016 abgeschlossene, von den Philippinen initiierte Schiedsverfahren zur Südchinesischen See hat dazu geführt, dass weitgehend alle maritimen Ansprüche Chinas als rechtlich unwirksam erklärt worden sind. Auch die Aufschüttung künstlicher Inseln durch China wurde als widerrechtlich bezeichnet. China hat verbal sehr scharf darauf reagiert und die Zuständigkeit und Unabhängigkeit des Schiedsgerichtes bezweifelt. Diese Reaktionen muss man noch als relativ zurückhaltend bewerten, denn außer verbalen Attacken hat China im Gegensatz zu vielen Erwartungen wenig unternommen.
Assessment of macroprolactinemia inpatients with prolactinoma
Authors: Dogansen Sema Ciftci , Yalin Gulsah Yenidunya , Yarman Sema 
Published: June 2017

Abstract

Purpose
Macroprolactin, the high-molecular mass prolactin isoform, is considered to be an inactive product with extrapituitary origin. Although macroprolactinemia is considered a benign condition, there is evidence of overlapping clinical features among patients with hyperprolactinemia. Data on the prevalence of macroprolactinemia in prolactinomas is also quite limited. The aim of this study was to assess the prevalence of macroprolactinemia in our patients with prolactinoma.

Methods
The study included patients with macroprolactinoma (n=50) and microprolactinoma (n=16). Prolactin level was measured with an electrochemiluminescent immunoassay, and macroprolactinemia was defined as the percentage of prolactin recovery <40% after the polyethylene glycol precipitation.

Results
Macroprolactinemia was not detected in our patients with prolactinoma (the percentage of PRL recovery range; 55%–96%). The mean percentage of prolactin recovery was similar in patients with macroprolactinoma and microprolactinoma (67.7%±8.0% and 70%±9.4%, respectively, p=0.96).

Conclusion
Macroprolactinemia is generally associated with negative findings on pituitary imaging. Although the monomeric prolactin is dominant, rarely macroprolactin may also be present in prolactinomas. We did not detect presence of macroprolactin in any of the patients and there was no statistically significant difference between micro- and macroprolactinomas in terms of prolactin recovery.
A New Genus, New Species and New Records of Ulidiidae (Diptera, Tephritoidea) from Colombia
Authors: Kameneva E. P. , Korneyev V. A. , Ramos-Pastrana Y. 
Published: June 2017

Abstract
A preliminary list of the picture-winged flies known from Columbia is supplemented by 15 species based predominantly on the materials from the National Museum of Natural History, Washington, D.C., USA and now contains 28 species, including Xycores igniceps gen. & sp. n. from Venezuela and Colombia. The new genus belongs to the subfamily Otitinae and is preliminarily assigned to the tribe Cephaliini by the combination of the high clypeus, strongly widened palp, setulose vein R1, and ejaculator with short sperm pump and long fan-like apodeme. It clearly differs from other members of the tribe by the combination of elongate, narrow, apically truncated flagellomere 1, robust, mainly shining thorax with pair of microtrichose vittae, well developed proepisternal, postpronotal, acrostichal, 2 pairs of dorsocentral and scutellar setae, wing with entirely setulose vein R1 abdominal tergites devoid of microtrichia, sternites and abdominal pleura narrow, male genitalia with short epandrium, numerous (7–8) prensisetae arranged into a row along posterior margin, shallow hypandrium with pair of setulose pregonites, no postgonites or epiphallus, and an almost bare phallus with a pair of long spines submedially.
Analysis of Peristaltic Transport of Non-Newtonian Fluids Through Nonuniform Tubes: Rabinowitsch Fluid Model
Authors: Singh U.P. , Medhavi Amit , Gupta R.S. , Bhatt Siddharth Shankar 
Published: June 2017

Abstract
Peristaltic transport is an important mechanism of physiological phenomenon and peristaltic pumps. With the advancement of medical science, it has been established that the physiological fluids do not behave like Newtonian fluids. Therefore, in order to understand the behaviour and properties of physiological fluids during peristalsis, selection of appropriate fluid model is of great importance. In the present investigation, properties of peristaltic transport through nonuniform tube have been studied for non-Newtonian fluids using Rabinowitsch fluid model. Theoretical analysis has been presented for long wavelength and low Reynolds number approximation. To analyse various properties of the flow, analytical expressions for velocity, pressure gradient, pressure rise, friction force, and temperature have been obtained. The numerical results for the same have been obtained to present the effect of various physical and flow parameters on fluid velocity, pressure rise, friction force, and temperature. Significant variation of these properties has been observed in the analysis for non-Newtonian nature of the fluid and nonuniformity of the tube.
Complete X-ray single-crystal structure determination and Raman spectrum of NH4[C(CN)3]
Authors: Reckeweg Olaf , Schulz Armin , DiSalvo Francis J. 
Published: June 2017

Abstract
The crystal structure of NH4[C(CN)3] has been determined via X-ray single-crystal methods at 203(2) K corroborating earlier results. Additionally, the hydrogen positions have been determined and the Raman spectrum of the title compound recorded on single crystals. The spectroscopic results are compared to those for related compounds.
p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling
Authors: Yosef Reut , Pilpel Noam , Papismadov Nurit , Gal Hilah , Ovadya Yossi , Vadai Ezra , Miller Stav , Porat Ziv , Ben‐Dor Shifra , Krizhanovsky Valery 
Published: June 2017

AbstractCellular senescence is a permanent state of cell cycle arrest that protects the organism from tumorigenesis and regulates tissue integrity upon damage and during tissue remodeling. However, accumulation of senescent cells in tissues during aging contributes to age‐related pathologies. A deeper understanding of the mechanisms regulating the viability of senescent cells is therefore required. Here, we show that the CDK inhibitor p21 (CDKN1A) maintains the viability of DNA damage‐induced senescent cells. Upon p21 knockdown, senescent cells acquired multiple DNA lesions that activated ataxia telangiectasia mutated (ATM) and nuclear factor (NF)‐κB kinase, leading to decreased cell survival. NF‐κB activation induced TNF‐α secretion and JNK activation to mediate death of senescent cells in a caspase‐ and JNK‐dependent manner. Notably, p21 knockout in mice eliminated liver senescent stellate cells and alleviated liver fibrosis and collagen production. These findings define a novel pathway that regulates senescent cell viability and fibrosis.
Tctex‐1 controls ciliary resorption by regulating branched actin polymerization and endocytosis
Authors: Saito Masaki , Otsu Wataru , Hsu Kuo‐Shun , Chuang Jen‐Zen , Yanagisawa Teruyuki , Shieh Vincent , Kaitsuka Taku , Wei Fan‐Yan , Tomizawa Kazuhito , Sung Ching‐Hwa 
Published: June 2017

AbstractThe primary cilium is a plasma membrane‐protruding sensory organelle that undergoes regulated assembly and resorption. While the assembly process has been studied extensively, the cellular machinery that governs ciliary resorption is less well understood. Previous studies showed that the ciliary pocket membrane is an actin‐rich, endocytosis‐active periciliary subdomain. Furthermore, Tctex‐1, originally identified as a cytoplasmic dynein light chain, has a dynein‐independent role in ciliary resorption upon phosphorylation at Thr94. Here, we show that the remodeling and endocytosis of the ciliary pocket membrane are accelerated during ciliary resorption. This process depends on phospho(T94)Tctex‐1, actin, and dynamin. Mechanistically, Tctex‐1 physically and functionally interacts with the actin dynamics regulators annexin A2, Arp2/3 complex, and Cdc42. Phospho(T94)Tctex‐1 is required for Cdc42 activation before the onset of ciliary resorption. Moreover, inhibiting clathrin‐dependent endocytosis or suppressing Rab5GTPase on early endosomes effectively abrogates ciliary resorption. Taken together with the epistasis functional assays, our results support a model in which phospho(T94)Tctex‐1‐regulated actin polymerization and periciliary endocytosis play an active role in orchestrating the initial phase of ciliary resorption.
Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure
Authors: Smith Michael P , Rowling Emily J , Miskolczi Zsofia , Ferguson Jennifer , Spoerri Loredana , Haass Nikolas K , Sloss Olivia , McEntegart Sophie , Arozarena Imanol , von Kriegsheim Alex , Rodriguez Javier , Brunton Holly , Kmarashev Jivko , Levesque Mitchell P , Dummer Reinhard , Frederick Dennie T , Andrews Miles C , Cooper Zachary A , Flaherty Keith T , Wargo Jennifer A , Wellbrock Claudia 
Published: June 2017

AbstractApproaches to prolong responses to BRAF targeting drugs in melanoma patients are challenged by phenotype heterogeneity. Melanomas of a “MITF‐high” phenotype usually respond well to BRAF inhibitor therapy, but these melanomas also contain subpopulations of the de novo resistance “AXL‐high” phenotype. > 50% of melanomas progress with enriched “AXL‐high” populations, and because AXL is linked to de‐differentiation and invasiveness avoiding an “AXL‐high relapse” is desirable. We discovered that phenotype heterogeneity is supported during the response phase of BRAF inhibitor therapy due to MITF‐induced expression of endothelin 1 (EDN1). EDN1 expression is enhanced in tumours of patients on treatment and confers drug resistance through ERK re‐activation in a paracrine manner. Most importantly, EDN1 not only supports MITF‐high populations through the endothelin receptor B (EDNRB), but also AXL‐high populations through EDNRA, making it a master regulator of phenotype heterogeneity. Endothelin receptor antagonists suppress AXL‐high‐expressing cells and sensitize to BRAF inhibition, suggesting that targeting EDN1 signalling could improve BRAF inhibitor responses without selecting for AXL‐high cells.
PARTISIPASI MASYARAKAT DALAM PENGELOLAAN AREAL PERLINDUNGAN LAUT – BERBASIS MASYARAKAT DI KABUPATEN ADMINISTRASI KEPULAUAN SERIBU, DKI JAKARTA
Authors: Erwiantono Erwiantono , Amanah Siti , Asngari Pang S. , Kinseng Rilus A. 
Published: June 2017

Pada dua dekade terakhir, kondisi ekosistem terumbu karang di perairan Kepulauan Seribu telah menunjukkan degradasi yang mengkawatirkan. Untuk mengatasi permasalahan tersebut, mulai tahun 2004 Pemda Kabupaten Administrasi Kepulauan Seribu bersama masyarakat menerapkan program Areal Perlindungan Laut–Berbasis Masyarakat (APL–BM) di lima kelurahan. Tujuan penelitian adalah : (1) menganalisis tingkat partisipasi masyarakat dalam pengelolaan APL–BM, dan; (2) menganalisis faktor – faktor yang berpengaruh terhadap partisipasi masyarakat. Pengumpulan data dilakukan selama periode Juni 2011–Mei 2012 dengan menggunakan kuesioner, pengamatan dan kajian pustaka. Populasi pada penelitian ini adalah individu pemanfaat utama sumberdaya alam berbasis ekosistem terumbu karang secara langsung. Metode pengambilan contoh yang digunakan adalah acak berproporsi sehingga terpilih 202 responden. Data dianalisis dengan menggunakan statistika deskriptifdan inferensia dengan model persamaan struktural (SEM). Hasil penelitian menunjukkan : (1) tingkat partisipasi masyarakat dalam pengelolaan APL–BM pada keseluruhan tahapan kegiatan adalah rendah dan (2) faktor – faktor yang berpengaruh terhadap tingkat partisipasi masyarakat adalah kemampuan organisasi dan motivasi masyarakat. Kedua faktor tersebut dipengaruhi oleh indikator pendekatan komunikasi, kesesuaian konsepsi program dan intensitas peran penyuluhan. Title: Community’s Participation in Managing Community Based – Marine Protected Area in Kepulauan Seribu District, DKI JakartaIn the last two decades, the coral reef ecosystem in Kepulauan Seribu has shown a significant degradation. Considered this, in 2004 the government of Kepulauan Seribu District initiated collaborative program in five villages and the program called as community based–marine protected area. The researchobjectives were: (1) to analyze community’s participation level in managing marine protected area in Kepulauan Seribu District and (2) to analyze the determinant factors that influence the community’s participation. The data were collected from June 2011 – May 2012 by using questionnare, observation and reviewing existing documents. Units of analizing were 202 respondents of primary stakeholders that utilize fisheries–marine resources directly. The data were analyzed using descriptive and inferential statistics based on structural equation modelling (SEM). The conclusions of the study are: (1) the levelof community’s participation in managing marine protected is low and (2) this condition is influenced by community organisation’s ability and community’s motivation. Community organisation’s ability and motivation are in low level. The factors which influence community organisation’s’ ability and community’s motivation are communication approaches, the compatibility of program conception and intensity of extention agents roles.
PENGEMBANGAN ENERGI TERBARUKAN PADA PULAU-PULAU KECIL
Authors: Mira Mira , Muhartono Rizky , Suryawati Siti Hajar 
Published: June 2017

Penelitian ini bertujuan untuk melihat optimasi potensi pengembangan energi terbarukan dengan melihat aspek dari sisi suplai (potensi energi) dan dari sisi demand (potensi konsumen). Metode analisis data yang digunakan adalah analisis multikriteria dengan membuat prioritasi melalui bobot dan scoring. Hasil analisis skala prioritas wilayah pengembangan energi terbarukan mengindikasikan dari 5 wilayah yang disurvei, wilayah yang menjadi prioritas pengembangan energi gelombang dan arus laut dari prioritas tertinggi sampai terendah dengan skala prioritas masing-masing (0.76, 0.67, 0.65, 0.61, 0.51) adalah Raja Ampat , Larantuka, Bawean, Nusa Penida, dan Kabupaten Bangka. Sedangkan wilayah yang menjadi kurang prioritas dalam pengembangan energi terbarukan adalah Kabupaten Bangka, di Kecamatan Belinyu. Hal ini disebabkan dari sisi potensi arus tidak masuk dalam Arus Laut Indonesia (Arlindo) yang berpotensi untuk pengembangan energi arus. Guna mengoptimalkan potensi energi terbarukan seperti gelombang dan arus laut maka pengembangan energi terbarukan (arus dan gelombang laut) diharapkan secara teknis mudah dilaksanakan oleh masyarakat (kalau bisa teknologi yang digunakan harus disederhanakan), hal ini berkaitan dengan perawatan pasca pengembangan energi terbarukan terutama di pulau-pulau kecil.Title: Development Renewable Energi for Small Islands : Supply and Demand SideThe purpose of this study is to analyze the optimization potential renewable energi with a view aspects of the supply side (potential energi) and the demand side (potential consumers). Data analysis method used was multi-criteria analysis to make prioritization through weighting and scoring. The results of the analysis of priorities indicated from five regions surveyed, priority areas the development of energi waves and ocean currents from highest priority to lowest priority scale respectively (0.76, 0.67, 0.65, 0.61, 0.51) is Raja Ampat, Larantuka, Bawean Nusa Penida, and Bangka. Instead region becomes less priority in the development of renewable energi is Bangka, in the District Belinyu, because Bangka not included in the Indonesian Seas Flow (Arlindo). Development of renewable energi is expected to be technically easy to implement by the community (if it can be simplified technology used), it relates to the post-treatment of renewable energi development, especially in small islands.
Social affective variations in Brazilian Portuguese: a perceptual and acoustic analysis
Authors: Rilliard Albert , Moraes João Antônio 
Published: June 2017

Resumo: Este trabalho descreve e analisa um corpus de 17 atitudes prosódicas produzido por 21 falantes do português do Brasil (PB). A interpretação dada a essas atitudes baseia-se em um experimento de escolha livre (free-labelling) do qual participaram 22 ouvintes brasileiros. O agrupamento das diferentes expressões obtidas no experimento é relacionado aos parâmetros acústicos da prosódia (F0 , intensidade, duração), e sua interpretação é feita com base na literatura sobre a manifestação da expressividade na fala e nas teorias do uso simbólico da voz em interações (código da frequência, de Ohala, e código do esforço, de Gussenhoven). Os resultados mostram que as principais dimensões de sentido identificadas pelos ouvintes podem ser reagrupadas em três grandes categorias: valência positiva, expressões assertivas e expressões dubitativas, dimensões que se correlacionam com as medidas acústicas.Palavras-chave: prosódia; free-labelling; dimensões de sentido; medidas acústicas.Abstract: This work presents a description and an analysis of an attitudinal corpus recorded in Brazilian Portuguese by 21 speakers. The interpretation of their performances across 17 situations, by L1 speakers of Brazilian Portuguese, is studied thanks to a free-labelling experiment. The grouping of expressions is then related to acoustic parameters of prosody. The interpretation of these descriptions is done in the light of literature on expression of affect in voice, and theories of symbolic use of voice in spoken interactions (Ohala’s Frequency Code, and Gussenhoven’s Effort Code). Results show that the main dimensions of meaning retrieved by the listeners may be summarized as: positive valence, assertive and dubitative expressions. These dimensions do correlate with the acoustical measures.Keywords: prosody; free-labelling; dimensions of meaning; acoustic measures.
Prosódia de enunciados declarativos e interrogativos totais nas variedades de Salvador, Fortaleza e Rio de Janeiro / Prosody of declarative and interrogative modalities in Salvador, Fortaleza, and Rio de Janeiro varieties
Authors: Couto Leticia Rebollo Couto , Silva Carolina Gomes da , Miranda Luma da Silva 
Published: June 2017

Resumo: Este trabalho tem como objetivo descrever diferenças entre variedades dialetais do português falado em Salvador, Fortaleza e Rio de Janeiro, Brasil, tanto nas sentenças declarativas quanto nas interrogativas. A análise de parâmetros prosódicos (frequência fundamental, duração, intensidade) é feita no núcleo final de sentenças oxítonas, paroxítonas e proparoxítonas. Há diferenças prosódicas sistemáticas entre as duas modalidades (declarativa e interrogativa): um tom alto ou subida de F0 no núcleo das interrogativas e, ao contrário, um tom baixo ou descida de F0 no núcleo das declarativas. Variações dialetais também são observadas. Os acentos tonais nucleares H + L*L% para as declarativas e L + H*L% para as interrogativas, propostos por Moraes (2008), são observados nos falantes do Rio de Janeiro – sendo este último truncado ou comprimido em sentenças oxítonas, devido à falta do material postônico. Entretanto, nas variedades de Salvador e Fortaleza, as interrogativas também podem ser realizadas com um padrão L + H*H%. Maior elisão de sílabas é observada nos falantes de Fortaleza. Palavras-chave: prosódia; entoação; sentenças declarativas; sentenças interrogativas totais; variação dialetal.Abstract: This work aims at describing differences between the dialectal varieties of Portuguese spoken at Salvador, Fortaleza and Rio de Janeiro, Brazil, in both the declarative and interrogative modalities. Analyses of prosodic parameters (fundamental frequency, duration, intensity) are made on the final nucleus of oxytonic, paroxytonic and proparoxytonic sentences. There are systematic prosodic changes between modalities – with a higher / rising F0 in interrogative nucleus where it is lower / decreasing for declaratives. The interrogative nucleus are also longer and stronger than the declaratives. Dialectal variations are also observed. The accentual patterns H + L*L% for declaratives and L + H*L% for interrogatives proposed by Moraes (2008) are observed in Rio de Janeiro speakers – the latter being truncated or compressed in oxytonic sentences due to lack of post-tonic material. Meanwhile, in the Salvador and Fortaleza varieties, interrogatives may also be performed with a L + H*H% pattern. More syllable elisions are also observed in Fortaleza speakers.Keywords: prosody; intonation; declarative sentences; yes/no questions; dialectal variation.
Desambiguização de sentenças na interface fonologia-sintaxe: resultados perceptuais / Sentence disambiguation in the phonology-syntax interface: results from a comprehension study
Authors: Angelo Melanie Campilongo , Santos Raquel Santana 
Published: June 2017

Resumo: Este artigo analisa a compreensão no português brasileiro da pista prosódica de duração de sílabas em sentenças ambíguas do tipo SN1- V-SN2-Atributo (e.g. ‘A mãe encontrou a filha suada’). Fonologicamente, tais leituras podem ser explicadas pelo fato de o atributo poder ou não se juntar a seu núcleo na construção do domínio da frase fonológica (NESPOR; VOGEL, 1986), e de que, se há fronteira de domínios, um alongamento é esperado (FOUGERON; KEATING, 1997). O estudo propõe que o alongamento é um fenômeno opcional no PB. Um experimento de picture matching é aplicado para versões de estruturas de aposição não local e local de nove sentenças. Os resultados apontaram para diferenças significativas conforme o tipo de estrutura sintática. As diferentes sentenças também se mostraram relevantes para a interpretação de que, ainda que o alongamento seja opcional na produção, uma vez realizado, ele serve como condutor para uma interpretação não local. Os resultados para uma interpretação local parecem decorrer da interação entre o Princípio de Late Closure (FRAZIER, 1979) com a estrutura prosódica da sentença. Por fim, a análise evidencia que estruturas do tipo small clause interferem no processo de alongamento e, assim, este artigo defendeue isso ocorre porque a reestruturação prosódica é bloqueada neste tipo de estrutura sintática.Palavras-chave: aposição local; aposição não local; fronteira prosódica; alongamento; small clauses.Abstract: This article discusses the comprehension of syllable duration in Brazilian Portuguese as a prosodic cue in ambiguous sentences with a NP1-V-NP2-attribute structure (e.g. ‘The mother has found her daughter sweating’). Phonologically, interpretations of the above-mentioned structure can be explained by the fact that attributes may or may not join the head in the construction of the phonological phrase domain (NESPOR; VOGEL, 1986), and because lengthening is expected when there is a boundary (FOUGERON; KEATING, 1997). We suggest that lengthening exists in BP as an optional phenomenon. We ran a picture matching experiment, with versions of structures with high and low attachment of 9 sentences. Overall results showed significant differences for type of syntactic structure. The different sentences also played a role in the results, indicating that although lengthening is optional in production, once it has been performed, it leads to a high attachment reading. The Low Attachment Principle (FRAZIER, 1979) seems to play a role in the results for sentences with low attachment. Finally, the findings signal also that sentences which allow small clause constructions may interfere with the lengthening process; and we argue that this happens because restructuring is blocked in this kind of structure.Keywords: low attachment; high attachment; prosodic boundary; lengthening; small clauses.