bluuebunny/crossref_metadata_2025_split huggingface dataset:
Localized translation regulates cell adhesion and transendothelial migration
Authors: Bergeman Jonathan , Caillier Alexia , Houle François , Gagné Laurence M. , Huot Marc-Étienne 
Published: September 2016

ABSTRACT
Epithelial-to-mesenchymal transition (EMT) is a process by which cancer cells gain the ability to leave the primary tumor site and invade surrounding tissues. These metastatic cancer cells can further increase their plasticity by adopting an amoeboid-like morphology, by undergoing mesenchymal-to-amoeboid transition (MAT). We found that adhering cells produce spreading initiation centers (SICs), transient structures that are localized above nascent adhesion complexes, and share common biological and morphological characteristics associated with amoeboid cells. Meanwhile, spreading cells seem to return to a mesenchymal-like morphology. Thus, our results indicate that SIC-induced adhesion recapitulates events that are associated with amoeboid-to-mesenchymal transition (AMT). We found that polyadenylated RNAs are enriched within SICs, blocking their translation decreased adhesion potential of metastatic cells that progressed through EMT. These results point to a so-far-unknown checkpoint that regulates cell adhesion and allows metastatic cells to alter adhesion strength to modulate their dissemination.
The Anthropological Meaning of the Network of Pedagogical Community and Its Implementation Through the Artifact-Pedagogy
Authors: �������  , Alferov M. , �������  , Nevskaya O. , ��������  , Fyedorova Yuliya 
Published: September 2016

The article deals with the communication network of pedagogical communities and artifact-pedagogy, the authors pay attention to the meaning of
metasubject interaction of teachers in the teaching of network communities.
SHOULD THE UK HAVE BREXITED THE EUROPEAN UNION?
Authors: Saaty Thomas L. , Wei Lirong 
Published: September 2016

This paper is an analysis of Brexit, and asked the question, “Should the UK have Brexited the European Union?” We use the Analytic Hierarchy Process (AHP) to model the decision based on Benefit-Opportunities-Costs and Risks (BOCR). The AHP structure considers various factors that may be taken into consideration from the perspective of the UK (Saaty, 1980). Questionnaires were used to obtain pairwise comparison judgments from experts and used to derive priorities for the factors and final decision to Brexit. The BOCR model results are combined in two ways. Both results show that the UK should remain a member of the EU. The referendum used showed the opposite result. The approach followed here can be used to educate people when voting on similar decisions.
Linear stability and resonance of triangular equilibrium points in elliptic restricted three body problem with radiating primary and triaxial secondary
Authors: Usha T. , Narayan A. 
Published: September 2016

The present paper studies the linear stability of the triangular equilibrium points of the system. The system comprises of a radiating primary and a triaxial secondary in elliptic restricted three body problem. The existence of third order resonances has been shown and the linear stability has been analyzed for these resonance cases. For the resonance case, and , the conditions of the linear stability are satisfied and the system is stable. But, for the resonance cases and the system is unstable.
Beyond Dinitrophenol Interaction with Tryptophan-Based Compounds
Authors: Zaharia Marius , Drochioiu Gabi , Zbancioc Gheorghiță , Grădinaru Vasile Robert 
Published: September 2016

Abstract
The effects of 2,4-dinitrophenol (2,4-DNP) on the spectroscopic parameters (UV-Vis or FT-IR absorbance) or fluorescence emission of tryptophan and glycyl-tryptophan were studied. A quenching phenomenon of fluorescence was observed, attributed to interactions between the indole ring of the fluorophore and the aromatic ring of the quencher. The analysis of fluorescence spectra confirms that the quenching is dictated by 2,4-DNP concentration and pH. A combined mechanism of static and dynamic quenching was detected. The quenching phenomenon observed in this work could be employed to explain the mechanism of action of such compounds on large fluorescent peptides or proteins.
Urban agglomerations and transformations of medium-sized towns in Poland
Authors: Runge Anna 
Published: September 2016

Abstract
This analysis investigates medium-sized towns in Poland, i.e. those with a population between 20–100 thousand, located up to 100 km away from the main city of the agglomeration. The aim of this article is to compare the level of socio-economic development of Polish towns depending on their location in relation to the main city in the largest agglomerations in 1998 and 2013. Three zones of distance from the main city of each agglomeration have been taken into consideration: a. the inner zone, reaching up to 25 km from the main city; b. the outer zone located at a distance of 25 to 50 km from the main city, and c. the peripheral zone, located at a distance of 50 to 100 km from the main city and including the medium-size towns located outside the agglomeration system. This analysis of the distribution of medium-sized towns and their level of socio-economic development has shown various levels of changes which depend on the distance from the main city of the agglomeration. In 1998, the highest level of development of the medium-sized towns was recorded in towns outside of these agglomeration systems, i.e. those located most remotely from the main city (peripheral zone). Most of the medium-sized towns are situated at a distance of 50–100 km from Warszawa, Kraków, Łódź, Lublin, Gdańsk and have developed their own local, or even regional labour markets and some of them have even provided administrative functions in the past as voivodeship capitals. Only in the Poznań agglomeration, the level of development of medium-sized towns was higher in the immediate surroundings of the main city (25 km). The medium-sized towns in all zones of the distance from the main city in the Wrocław agglomeration represented a similar level of development. By 2013, the level of development of the medium-sized towns in the peripheral zone in all investigated settlement systems had decreased, with a significant improvement in the level of development of the towns in the immediate surroundings of the main city. Such situation occurs especially in the conurbation of Gdańsk and the agglomerations of Warszawa, Kraków and Poznań. This shows that the largest cities of Poland are the main engines of economic development by stimulating their surroundings and their impact on the surrounding areas. Unfortunately, the towns located in the marginal zones of several agglomerations (the zone 25–50 km away from the main city) experience certain disadvantages, such as the process of “the backwash effect”. Furthermore, the lack of developmental impulses is observed in many medium-sized towns at the distance of 50-100 km from the main city of the agglomeration.
Groundwater renewable resources in karst areas, the case of the Kleśnica River basin (Sudety Mountains, Poland)
Authors: Olichwer Tomasz , Otrębski Adrian 
Published: September 2016

Abstract
The karst-fractured medium constitutes a considerable groundwater capacity, as shown on the example of the Kleśnica River basin. The paleozoic crystalline limestones in the research area are good collectors of the groundwater. The Kleśnica River basin, one of the largest crystalline limestone lens, is situated in the Sudety Mountains. Groundwater renewable resources were distinguished with the use of hydrological methods, on the basis of hydrometric measurements of the flow discharge of the Kleśnica River during the low-flow period (2009–2010). The mean module of the groundwater runoff equals 20.79 dm3/s*km2, and includes the study of the river catchments areas with extremely high groundwater runoff. The groundwater renewable resources in the Kleśnica River basin are almost twice higher than in the neighbouring river basins (the Kamienica and Morawka River basins), in which there are no significant outcrops of carbonate rocks. These considerable renewable resources also provide a high runoff in the spring, 7.98 dm3/s*km2. The high values of the runoffs indicate, that the groundwater is coming from the regional circulation system and, on a smaller scale, from the local system. The groundwater from both systems flows into the fractured system through the karst of carbonate massif rocks and their weathering fringes.
Reduced plantar sole sensitivity facilitates early adaptation to a visual rotation pointing task when standing upright
Authors: Maxime Billot , Normand Teasdale , Léandre Gagné Lemieux , Mathieu Germain Robitaille , Martin Simoneau 
Published: September 2016

Abstract
Humans are capable of pointing to a target with accuracy. However, when vision is distorted through a visual rotation or mirror-reversed vision, the performance is initially degraded and thereafter improves with practice. There are suggestions this gradual improvement results from a sensorimotor recalibration involving initial gating of the somatosensory information from the pointing hand. In the present experiment, we examined if this process interfered with balance control by asking participants to point to targets with a visual rotation from a standing posture. This duality in processing sensory information (i.e., gating sensory signals from the hand while processing those arising from the control of balance) could generate initial interference leading to a degraded pointing performance. We hypothesized that if this is the case, the attenuation of plantar sole somatosensory information through cooling could reduce the sensorimotor interference, and facilitate the early adaptation (i.e. improvement in the pointing task). Results supported this hypothesis. These observations suggest that processing sensory information for balance control interferes with the sensorimotor recalibration process imposed by a pointing task when vision is rotated.
The effect of mobilization techniques by the OMT Kaltenborn-Evjenth Koncept’s therapy for the range of motion and pain of patients with coxarthrosis
Authors: Załoga Karolina , Dudziński Krzysztof 
Published: September 2016

Abstract
Introduction: Degenerative changes are one of the most often appearing causes of the affliction located in the locomotor system where the hip joint is one of the most common locations. One can observe such symptoms as: limited movement, pain and muscle weakness. One of the therapy methods that are aimed at improving movement and reducing the affliction are techniques used in manual therapy (e.g. mobilization). The Kaltenborn-Evjenth method has been applied in physiotherapy practice for many years. The aim of the research was to assess the effectiveness of mobilization techniques directed at the synovial capsule (manual therapy) while treating degenerative changes of the hip joint. In literature no report that refers precisely to the subject mentioned above was found. Being assessed was the influence of therapy on the range of the joints movement and the level of pain.
Material and methods: A group of 20 people with degenerative changes of the hip joint were examined (16 women and 4 men, average age - 65 years). Measurements of the hip joint range movement were performed (the flexion, extension, abduction, adduction and rotation) and the assessment of the level of felt pain (VAS) before and after the therapy. The therapy using mobilization techniques taken from the Kaltenborn-Evjenth concept was conducted in a series of 6 therapy sessions lasting 2 weeks.
Results: In all comparisons of the range of motion in the hip joint an increasing was stated (p < 0.001) after the therapy. In the case of pain level a decreasing was observed (p < 0.001) after the therapy.
Conclusions: It seems right to use manual therapy techniques in physiotherapy proceedings in the course of the degenerative disease of the hip joint, aimed on for e.g. the synovial capsule.
Investigation and optimization of the electro-discharge machining parameters of 2024 aluminum alloy and Al/7.5% Al2O3 particulate-reinforced metal matrix composite
Authors: Daneshmand Saeed , Masoudi Behnam 
Published: September 2016

Abstract
Being newly advanced materials, metal matrix composites enjoy the properties of high service temperature, light weight, high specific strength, good wear resistance, high stiffness, and a low thermal expansion coefficient. However, machining these materials by conventional methods is difficult. A key machining process for difficult-to-machine materials like composites is electro-discharge machining, which is widely used in non-conventional material removal processes. The current work aims to identify different parameters, such as voltage, current, pulse on-time, and pulse off-time, which influence the material removal rate (MRR), tool wear rate (TWR), and surface roughness (SR). By applying regression equations, a mathematical model is adopted to estimate MRR, TWR, and SR. The optimum machining parameters are investigated using the Taguchi method with L9 orthogonal array. The optimum values are also analyzed by multi-objective Taguchi method with calculation of total normalized quality loss (TNQL) and multi-signal to noise ratio (MSNR) included. Analysis of the Taguchi method introduced voltage and pulse off-time as the two main significant factors that influence the value of the material removal rate. The discharge current and pulse off-time also have a statistically significant impact on both tool wear rate and surface roughness.
Wars and Conflicts are Only Randomly Connected with Religion and Religious Beliefs. An Outline of Historical, Cognitive, and Evolutionary Approach
Authors: Szocik Konrad 
Published: September 2016

AbstractMany scholars that study of religion and religious beliefs find that they affect behavioral patterns. Some of them suggest that this impact is morally wrong because religion and religious beliefs can cause aggression, conflicts, and wars. However, it seems that this topic is more complicated and complex. Here I show that religion and religious beliefs can affect mentioned above morally wrong patterns only in some particular cases. Usually they do not do it. Here I show an outline of philosophical historical approach that was critically oriented against religion and that accused it about conflicts and wars. Then I briefly discuss two current scientific research approaches to the study of religion, cognitive and evolutionary. They falsify these critically oriented philosophers because they treat connection between religious beliefs and conflicts as random and necessary. The core idea of this paper assumes that religious beliefs do not affect aggression and wars directly. They can sometimes strengthen or weaken some biological mechanisms that then can be used to compete by conflicts or by not-violent inter-group competition.
A guide to lifting aperiodic structures
Authors: Baake Michael , Écija David , Grimm Uwe 
Published: September 2016

Abstract
The embedding of a given point set with non-crystallographic symmetry into higher-dimensional space is reviewed, with special emphasis on the Minkowski embedding known from number theory. This is a natural choice that does not require an a priori construction of a lattice in relation to a given symmetry group. Instead, some elementary properties of the point set in physical space are used, and explicit methods are described. This approach works particularly well for the standard symmetries encountered in the practical study of quasicrystalline phases. We also demonstrate this with a recent experimental example, taken from a sample with square-triangle tiling structure and (approximate) 12-fold symmetry.
Inferring Past Effective Population Size from Distributions of Coalescent Times
Authors: Gattepaille Lucie , Günther Torsten , Jakobsson Mattias 
Published: September 2016

Abstract
Inferring and understanding changes in effective population size over time is a major challenge for population genetics. Here we investigate some theoretical properties of random-mating populations with varying size over time. In particular, we present an exact solution to compute the population size as a function of time, Ne(t), based on distributions of coalescent times of samples of any size. This result reduces the problem of population size inference to a problem of estimating coalescent time distributions. To illustrate the analytic results, we design a heuristic method using a tree-inference algorithm and investigate simulated and empirical population-genetic data. We investigate the effects of a range of conditions associated with empirical data, for instance number of loci, sample size, mutation rate, and cryptic recombination. We show that our approach performs well with genomic data (≥ 10,000 loci) and that increasing the sample size from 2 to 10 greatly improves the inference of Ne(t) whereas further increase in sample size results in modest improvements, even under a scenario of exponential growth. We also investigate the impact of recombination and characterize the potential biases in inference of Ne(t). The approach can handle large sample sizes and the computations are fast. We apply our method to human genomes from four populations and reconstruct population size profiles that are coherent with previous finds, including the Out-of-Africa bottleneck. Additionally, we uncover a potential difference in population size between African and non-African populations as early as 400 KYA. In summary, we provide an analytic relationship between distributions of coalescent times and Ne(t), which can be incorporated into powerful approaches for inferring past population sizes from population-genomic data.
Extraction of the Constituent Subgenomes of the Natural Allopolyploid Rapeseed (Brassica napus L.)
Authors: Zhu Bin , Tu Yuqin , Zeng Pan , Ge Xianhong , Li Zaiyun 
Published: September 2016

Abstract
As the dynamic nature of progenitor genomes accompanies the speciation by interspecific hybridization, the extraction of the constituent subgenome(s) from a natural allopolyploid species of long history and then restitution of the progenitor(s) provides the unique opportunity to study the genome evolution and interplay. Herein, the A subgenome from the allotetraploid oilseed rape (Brassica napus L., AACC) was extracted through inducing the preferential elimination of C-subgenome chromosomes in intertribal crosses and the progenitor B. rapa was restituted (RBR). Then by crossing and backcrossing RBR with B. napus donor, the C subgenome was in situ dissected by adding each of its nine chromosomes to the extracted A subgenome and establishing the whole set of monosonic alien addition lines (MAALs). RBR from spring-type B. napus genotype “Oro” expressed a phenotype resembling some type of B. rapa never observed before, but showed a winter-type flowering habit. This RBR had weaker growth vigor and suffered more seriously from biotic and abiotic stresses compared with Oro. The phenotypes specific for these MAALs showed the location of the related genes on the particular C-subgenome chromosomes. These MAALs exhibited obviously different frequencies in homeologous pairing and transmission of additional C-subgenome chromosomes, which were associated with the distinct degrees of their relatedness, and even with the possible genetic regulation for meiotic pairing evolved in B. napus. Finally, large scaffolds undetermined for sequence assembly of B. napus were anchored to specific C-subgenome chromosomes using MAALs.
Suicide in Elementary School-Aged Children and Early Adolescents
Authors: Sheftall Arielle H. , Asti Lindsey , Horowitz Lisa M. , Felts Adrienne , Fontanella Cynthia A. , Campo John V. , Bridge Jeffrey A. 
Published: September 2016

BACKGROUND AND OBJECTIVES:Suicide in elementary school–aged children is not well studied, despite a recent increase in the suicide rate among US black children. The objectives of this study were to describe characteristics and precipitating circumstances of suicide in elementary school–aged children relative to early adolescent decedents and identify potential within-group racial differences.METHODS:We analyzed National Violent Death Reporting System (NVDRS) surveillance data capturing suicide deaths from 2003 to 2012 for 17 US states. Participants included all suicide decedents aged 5 to 14 years (N = 693). Age group comparisons (5–11 years and 12–14 years) were conducted by using the χ2 test or Fisher’s exact test, as appropriate.RESULTS:Compared with early adolescents who died by suicide, children who died by suicide were more commonly male, black, died by hanging/strangulation/suffocation, and died at home. Children who died by suicide more often experienced relationship problems with family members/friends (60.3% vs 46.0%; P = .02) and less often experienced boyfriend/girlfriend problems (0% vs 16.0%; P &lt; .001) or left a suicide note (7.7% vs 30.2%; P &lt; .001). Among suicide decedents with known mental health problems (n = 210), childhood decedents more often experienced attention-deficit disorder with or without hyperactivity (59.3% vs 29.0%; P = .002) and less often experienced depression/dysthymia (33.3% vs 65.6%; P = .001) compared with early adolescent decedents.CONCLUSIONS:These findings raise questions about impulsive responding to psychosocial adversity in younger suicide decedents, and they suggest a need for both common and developmentally-specific suicide prevention strategies during the elementary school–aged and early adolescent years. Further research should investigate factors associated with the recent increase in suicide rates among black children.
Transformaciones territoriales: una categoría de análisis para explicar las dinámicas de conformación territorial.
Authors: Ramirez Camilo Mahecha 
Published: September 2016

<p>La siguiente reflexión tiene como objeto proponer la construcción de una categoría de análisis que permita dar cuenta la forma en que se ha trasformado el territorio colombiano en el marco del modelo extractivo, con especial énfasis en la industria petrolera. Se propone un recorrido analítico sobre conceptos claves que dan forma a la propuesta de elevar a nivel de categoría las “transformaciones territoriales.” Teniendo como principales elementos los impactos de la globalización en el modelo de desarrollo, así como los procesos de descentralización, el conflicto armado y las resistencias sociales. En este sentido, se toma como estudio de casoel departamento de Putumayo intentando entender sus dinámicas territoriales desde la categoría de análisis propuesta.</p>