bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRICE DETERMINANTS OF BRED COWS
Authors: MITCHELL JAMES L. , PEEL DERRELL S. , BRORSEN B. WADE 
Published: September 2017

AbstractHedonic modeling of Oklahoma cow auction data is used to determine the market value of bred cow characteristics. We use Agricultural Marketing Service data that let us consider more years and more lots of cattle than is typical for a cattle hedonic study. The greatest price premiums were for black, late-gestating cows, categorized as high quality by market reporters and weighing between 1,600 and 1,700 lb. Previous research on optimal cow size finds much smaller-size cows are optimal, and our research finds that larger cows receive a lower price per pound but still receive a substantially higher price per head.
Facilitators and Barriers to Preparedness Partnerships: A Veterans Affairs Medical Center Perspective
Authors: Schmitz Susan , Wyte-Lake Tamar , Dobalian Aram 
Published: September 2017

AbstractObjectiveThis study sought to understand facilitators and barriers faced by local US Department of Veterans Affairs Medical Center (VAMC) emergency managers (EMs) when collaborating with non-VA entities.MethodsTwelve EMs participated in semi-structured interviews lasting 60 to 90 minutes discussing their collaboration with non-VAMC organizations. Sections of the interview transcripts concerning facilitators and barriers to collaboration were coded and analyzed. Common themes were organized into 2 categories: (1) internal (ie, factors affecting collaboration from within VAMCs or by VA policy) and (2) external (ie, interagency or interpersonal factors).ResultsRespondents reported a range of facilitators and barriers to collaboration with community-based agencies. Internal factors facilitating collaboration included items such as leadership support. An internal barrier example included lack of clarity surrounding the VAMC’s role in community disaster response. External factors noted as facilitators included a shared goal across organizations while a noted barrier was a perception that potential partners viewed a VAMC partnership with skepticism.ConclusionFederal institutions are important partners for the success of community disaster preparedness and response. Understanding the barriers that VAMCs confront, as well as potential facilitators to collaboration, should enhance the development of VAMC–community partnerships and improve community health resilience. (Disaster Med Public Health Preparedness. 2018;12:431–436)
Use of Implementation Science for a Sustained Reduction of Central-Line–Associated Bloodstream Infections in a High-Volume, Regional Burn Unit
Authors: Sood Geeta , Caffrey Julie , Krout Kelly , Khouri-Stevens Zeina , Gerold Kevin , Riedel Stefan , McIntyre Janet , Maragakis Lisa L. , Blanding Renee , Zenilman Jonathan , Bennett Richard , Pronovost Peter 
Published: September 2017

OBJECTIVEWe describe the use of implementation science at the unit level and organizational level to guide an intervention to reduce central-line–associated bloodstream infections (CLABSIs) in a high-volume, regional, burn intensive care unit (BICU).DESIGNA single center observational quasi-experimental study.SETTINGA regional BICU in Maryland serving 300–400 burn patients annually.INTERVENTIONSIn 2011, an organizational-level and unit-level intervention was implemented to reduce the rates of CLABSI in a high-risk patient population in the BICU. At the organization level, leaders declared a goal of zero infections, created an infrastructure to support improvement efforts by creating a coordinating team, and engaged bedside staff. Performance data were transparently shared. At the unit level, the Comprehensive Unit-based Safety Program (CUSP)/ Translating Research Into Practice (TRIP) model was used. A series of interventions were implemented: development of new blood culture procurement criteria, implementation of chlorhexidine bathing and chlorhexidine dressings, use of alcohol impregnated caps, routine performance of root-cause analysis with executive engagement, and routine central venous catheter changes.RESULTSThe use of an implementation science framework to guide multiple interventions resulted in the reduction of CLABSI rates from 15.5 per 1,000 central-line days to zero with a sustained rate of zero CLABSIs over 3 years (rate difference, 15.5; 95% confidence interval, 8.54–22.48).CONCLUSIONSCLABSIs in high-risk units may be preventable with the a use a structured organizational and unit-level paradigm.Infect Control Hosp Epidemiol 2017;38:1306–1311
Functional laws for trimmed Lévy processes
Authors: Buchmann Boris , Ipsen Yuguang F. , Maller Ross 
Published: September 2017

AbstractTwo different ways of trimming the sample path of a stochastic process in 𝔻[0, 1]: global ('trim as you go') trimming and record time ('lookback') trimming are analysed to find conditions for the corresponding operators to be continuous with respect to the (strong)J1-topology. A key condition is that there should be no ties among the largest ordered jumps of the limit process. As an application of the theory, via the continuous mapping theorem, we prove limit theorems for trimmed Lévy processes, using the functional convergence of the underlying process to a stable process. The results are applied to a reinsurance ruin time problem.
Carbon and Oxygen Isotope Composition of Early Holocene Olivella Shell Beads from the Northwest Coast, USA
Authors: Hadden Carla S , Cherkinsky Alexander , Smith Geoffrey M , Ollivier Aaron P , Pan Hai 
Published: September 2017

AbstractArchaeological investigations of the age and origins of marine shell beads are important for understanding the emergence and maintenance of long-distance trade networks in prehistory. In this paper we expand upon and re-examine the incremental carbon (14C and δ13C) and oxygen (δ18O) isotope data from two Olivella biplicata shell beads from the LSP-1 Rockshelter, Oregon, USA, to address two common problems in dating marine shell trade goods: (1) the source region is large, adding to uncertainty regarding the appropriate specification of ΔR; and (2) the 14C activity within individual specimens is variable. Although this combination of factors severely limits the dating precision that is possible, we recommend a sampling and calibration approach that accounts for these added sources of uncertainty and minimizes the loss of precision. We recommend (1) sequential sampling in order to quantify the range of variability in 14C within shells; (2) a Bayesian calibration procedure that models the 14C dates as an ontogenetic sequence, in this case constrained by stable isotope sclerochronology; and (3) specifying ΔR in a manner that accounts for the full range of possible reservoir offsets in the source region.
Dietary starch types affect liver nutrient metabolism of finishing pigs
Authors: Xie Chen , Li Yanjiao , Li Jiaolong , Zhang Lin , Zhou Guanghong , Gao Feng 
Published: September 2017

AbstractThis study aimed to evaluate the effect of different starch types on liver nutrient metabolism of finishing pigs. In all ninety barrows were randomly allocated to three diets with five replicates of six pigs, containing purified waxy maize starch (WMS), non-waxy maize starch (NMS) and pea starch (PS) (the amylose to amylopectin ratios were 0·07, 0·19 and 0·28, respectively). After 28 d of treatments, two per pen (close to the average body weight of the pen) were weighed individually, slaughtered and liver samples were collected. Compared with the WMS diet, the PS diet decreased the activities of glycogen phosphorylase, phosphoenolpyruvate carboxykinase and the expression of phosphoenolpyruvate carboxykinase 1 in liver (P<0·05). Moreover, the lipid contents, the concentrations of acetyl-CoA carboxylase, fatty acid synthetase and the expression of sterol regulatory element binding protein-1c in liver of PS and NMS diets were lower than those of WMS diet (P<0·05). However, no effect was observed in the activity of hepatic lipase, the expressions of carbohydrate-responsive element-binding protein, liver X receptor and PPARα(P>0·05). Compared with the WMS diet, the PS diet reduced the expressions of glutamate dehydrogenase and carbamoyl phosphate synthetase 1 in liver (P<0·05). PS diet decreased the expression of the insulin receptor, and increased the expressions of mammalian target of rapamycin complex 1 and ribosomal protein S6 kinaseβ-1 in liver compared with the WMS diet (P<0·05). These findings indicated that the diet with higher amylose content could down-regulate gluconeogenesis, and cause less fat deposition and more protein deposition by affecting the insulin/PI3K/protein kinase B signalling pathway in liver of finishing pigs.
Depositional environment and climate changes during the Holocene in Grande Valley, Fildes Peninsula, King George Island, Antarctica
Authors: Chu Zhuding , Sun Liguang , Wang Yuhong , Huang Tao , Zhou Xin 
Published: September 2017

AbstractA 9.24 m sediment core, GA-2, was collected on the coastal platform of Grande Valley, a relatively narrow and shallow fjord in Fildes Peninsula, King George Island, Antarctica. The sediment was formed between 6600 and 2000 cal. yrbpaccording to accelerator mass spectrometry (AMS)14C dating of five bulk sediment samples. The comprehensive proxy indicators (grain size, loss on ignition at 550°C, magnetic susceptibility, elements) were analysed, and three separate depositional environments and an alternating climate change pattern were identified. Grande Valley experienced a warm marine environment between 6600 and 5800 cal. yrbp, a minor cooling between 5800 and 4800 cal. yrbp, the transition from cool to warm during 4800–4400 cal. yrbp, a mid-Holocene climatic optimum between 4400 and 2700 cal. yrbp, and the onset of the Neoglacial at 2700 cal. yrbp. This study reconstructed the environmental history of Grande Valley during the mid–late Holocene, provides the missing marine record of historical climate for the western coast of Fildes Peninsula and lays the foundation for further study of the climate and environment changes therein. Our finding that the sea level wasc.12 m a.m.s.l. at 2000 cal. yrbpallows for detailed reconstruction of Holocene sea level variations.
Modelling sequences and temporal networks with dynamic community structures
Authors: Peixoto Tiago P. , Rosvall Martin 
Published: September 2017

AbstractIn evolving complex systems such as air traffic and social organisations, collective effects emerge from their many components’ dynamic interactions. While the dynamic interactions can be represented by temporal networks with nodes and links that change over time, they remain highly complex. It is therefore often necessary to use methods that extract the temporal networks’ large-scale dynamic community structure. However, such methods are subject to overfitting or suffer from effects of arbitrary, a priori-imposed timescales, which should instead be extracted from data. Here we simultaneously address both problems and develop a principled data-driven method that determines relevant timescales and identifies patterns of dynamics that take place on networks, as well as shape the networks themselves. We base our method on an arbitrary-order Markov chain model with community structure, and develop a nonparametric Bayesian inference framework that identifies the simplest such model that can explain temporal interaction data.
Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage
Authors: Chen Poyu , Takatsuka Hirotomo , Takahashi Naoki , Kurata Rie , Fukao Yoichiro , Kobayashi Kosuke , Ito Masaki , Umeda Masaaki 
Published: September 2017

AbstractInhibition of cell division is an active response to DNA damage that enables cells to maintain genome integrity. However, how DNA damage arrests the plant cell cycle is largely unknown. Here, we show that the repressor-type R1R2R3-Myb transcription factors (Rep-MYBs), which suppress G2/M-specific genes, are required to inhibit cell division in response to DNA damage. Knockout mutants are resistant to agents that cause DNA double-strand breaks and replication stress. Cyclin-dependent kinases (CDKs) can phosphorylate Rep-MYBs in vitro and are involved in their proteasomal degradation. DNA damage reduces CDK activities and causes accumulation of Rep-MYBs and cytological changes consistent with cell cycle arrest. Our results suggest that CDK suppressors such as CDK inhibitors are not sufficient to arrest the cell cycle in response to DNA damage but that Rep-MYB-dependent repression of G2/M-specific genes is crucial, indicating an essential function for Rep-MYBs in the DNA damage response.
Neutrophil polarization by IL-27 as a therapeutic target for intracerebral hemorrhage
Authors: Zhao Xiurong , Ting Shun-Ming , Liu Chin-Hsuan , Sun Guanghua , Kruzel Marian , Roy-O’Reilly Meaghan , Aronowski Jaroslaw 
Published: September 2017

AbstractShortly after intracerebral hemorrhage, neutrophils infiltrate the intracerebral hemorrhage-injured brain. Once within the brain, neutrophils degranulate, releasing destructive molecules that may exacerbate brain damage. However, neutrophils also release beneficial molecules, including iron-scavenging lactoferrin that may limit hematoma/iron-mediated brain injury after intracerebral hemorrhage. Here, we show that the immunoregulatory cytokine interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Data from rodent models indicate that interleukin-27 modifies neutrophil maturation in the bone marrow, suppressing their production of pro-inflammatory/cytotoxic products while increasing their production of beneficial iron-scavenging molecules, including lactoferrin. Finally, interleukin-27 or lactoferrin administration results in reduced edema, enhanced hematoma clearance, and improved neurological outcomes in an animal model of intracerebral hemorrhage. These results suggest that interleukin-27/lactoferrin-mediated modulations of neutrophil function may represent a therapeutically viable concept for the modification of neutrophils toward a “beneficial” phenotype for the treatment of intracerebral hemorrhage.
Determination of Quality Changes in Peaches Wrapped in Active Paper and Stored at Ambient Temperature in Summer
Authors: Du Xiao-long , Li Hui , Zhou Wei-hong , Liu Ying , Li Jian-long 
Published: September 2017

AbstractPeaches are known for their palatable flavor and abundant nutrients. However, peaches are perishable, and the existing preservation techniques for peaches are still immature. To further extend the shelf life and prevent nutrient loss of perishable peaches under ambient temperature in summer (approximately 25–32 °C), we conducted experiments wrapping peaches (Prunus persica cv ‘Baihua’) in single- and composite-treated vegetal fibrous papers that contained calcium carbonate, phytic acid, Na-alginate and vitamin C. The pathogenic fungi that primarily caused peach decay during storage belonged to the genera of Penicillium, Botrytis, Aspergillus, Alternaria, and Rhizopus. After analyzing quality attributes, including weight loss, firmness, soluble sugar content, respiration rate, relative electric conductivity, malonaldehyde content, peroxidase activity and the decay index, we proved that vitamin C within the preservative paper greatly contributes to peach preservation. Combined with phytic acid and Na-alginate, the composite vitamin C preservative papers played significant roles in delaying fruit senescence, and 0.4% (w/v) vitamin C preservative paper with 1% Na-alginate could maintain quality and extend shelf life with the best effect. This preservation technique significantly postponed the respiration peak by 2–3 days and is a significant contribution to contemporary commercial production.
GATA3 regulates FLG and FLG2 expression in human primary keratinocytes
Authors: Zeitvogel Jana , Jokmin Neele , Rieker Samira , Klug Ilona , Brandenberger Christina , Werfel Thomas 
Published: September 2017

AbstractGATA3 is a transcription factor with an important role in atopic diseases because of its role in the differentiation of Th2 lymphocytes. Moreover, GATA3 is expressed in keratinocytes and has a role in keratinocyte differentiation and the establishment of the epidermal barrier. In this study, we investigated the role of GATA3 in keratinocytes in the context of epidermal barrier integrity under inflammatory skin conditions. When analysing skin samples from atopic dermatitis and psoriasis patients or healthy controls, we detected decreased expression of GATA3 in the stratum spinosum and stratum granulosum of atopic dermatitis and psoriasis patients when compared to healthy controls. Our cell cultures experiments revealed that a downregulation in GATA3 by shRNA leads to a significant reduction of filaggrin mRNA under atopic dermatitis-like conditions in keratinocytes. Overexpression of GATA3 in keratinocytes reversed this effect and significantly upregulated filaggrin and, furthermore, filaggrin-2 mRNA expression. Our results demonstrate that GATA3 is involved in the regulation of filaggrin and filaggrin-2 expression during inflammatory conditions in the skin. Thus, GATA3 may be of special importance for the establishment and maintenance of an intact epidermal barrier, especially in atopic dermatitis.
Hemoglobin enhances miRNA-144 expression and autophagic activation mediated inflammation of microglia via mTOR pathway
Authors: Wang Zhenyu , Yuan Bangqing , Fu Fenlan , Huang Shaokuan , Yang Zhao 
Published: September 2017

AbstractIntracerebral hemorrhage promotes autophagic activation of microglia and enhances neuroinflammation. MiRNAs are key factors to autophagy, contributed to negatively and posttranscriptionally regulate gene expression and function. However, the specific miRNAs involved in the intracerebral hemorrhage mediated microglia autophagic activation are unidentified. In this experiment, microglia was treated with hemoglobin. And then, miRNA-144 expression, autophagic activation and inflammation of microglia were detected. In addition, the mTOR target of miRNA-144 and its regulation were identified. Our data demonstrated that hemoglobin promoted miRNA-144 expression and autophagic activation mediated inflammation. Additionally, miRNA-144 targeted mTOR by directly interacting with the 3′ untranslated regions (UTRs), mutations of the binding sites abolish the miRNA-144 responsiveness. Overexpression of mTOR decreased autophagic activation and inflammation of microglia. Therefore, our results suggested that miRNA-144 contributed to hemoglobin mediated autophagic activation and inflammation of microglia via mTOR pathway. And miRNA based treatment provided novel therapeutical strategy for intracerebral hemorrhage.
Time-dependent effects of ipragliflozin on behaviour and energy homeostasis in normal and type 2 diabetic rats: continuous glucose telemetry analysis
Authors: Iuchi Hiroyuki , Sakamoto Masaya , Matsutani Daisuke , Suzuki Hirofumi , Kayama Yosuke , Takeda Norihiko , Minamisawa Susumu , Utsunomiya Kazunori 
Published: September 2017

AbstractSodium–glucose cotransporter 2 (SGLT2) inhibitors are oral antidiabetic drugs that promote urinary glucose excretion. Conversely, they cause behavioural changes, such as hyperphagia, that result in a positive energy balance. The relationship between energy homeostasis and SGLT2 inhibitors-induced behavioural changes remains unclear. Here we show that ipragliflozin, a SGLT2 inhibitor, time-dependently affects behaviour and enhances energy expenditure in normal and type 2 diabetic Goto–Kakizaki (GK) rats, using continuous glucose telemetry. Alongside increased urinary glucose excretion, ipragliflozin increased total food and water intakes in normal and GK rats. In normal rats, ipragliflozin treatment acutely disturbed the circadian rhythms of food and water intakes, activity, and body temperature. Subsequently, these rhythms gradually returned towards a normal state. However, activity and body temperature remained suppressed. In GK rats, ipragliflozin did not affect circadian rhythms. Blood glucose values assessed by glucose telemetry were significantly reduced in both ipragliflozin-treated groups. Despite these behavioural and glycaemic changes, ipragliflozin significantly increased oxygen consumption during dark and light periods in both groups. Ipragliflozin reduced body weight in normal rats only. Thus, ipragliflozin decreases blood glucose beyond compensatory hyperphagia in normal and GK rats, resulting in enhanced basal energy expenditure, despite acutely altering circadian rhythms in normoglycaemic individuals.
Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis
Authors: Lee Chang Hoon , Bae Su Jeong , Kim Miok 
Published: September 2017

AbstractEmerging evidence suggests that mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) is a key regulator of inflammatory diseases; however, the pathological role of MALT1 in rheumatoid arthritis (RA) is not well understood. Consequently, this protein has not been therapeutically targeted for the treatment of RA. MALT1 plays a role in the paracaspase pathway, has proteolytic activity and is involved in the regulation of inflammatory responses. In this study, we found that the MALT1-targeting inhibitory small molecule, MALT1 selective inhibitor 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide (MI-2) strongly suppresses the differentiation of monocytes into osteoclasts in the absence or presence of the inflammatory cytokine tumour necrosis factor α. Furthermore, MI-2 ameliorates pathologic bone erosion and synovitis in an in vivo mouse model of collagen-induced arthritis. Mechanistically, MI-2 blocked expression of the master osteoclast regulator – nuclear factor of activated T cells 1 (NFATc1) – by inhibiting nuclear factor κB (NF-κB), which is a critical regulator of NFATc1. These findings highlight the important regulatory role of MALT1 in the NF-κB–NFATc1-signalling axis during osteoclastogenesis and suggest that targeting MALT1 is a promising treatment option for rheumatoid arthritis.
A smart thermo- and pH-responsive microfiltration membrane based on three-dimensional inverse colloidal crystals
Authors: Yu Bing , Song Qianqian , Cong Hailin , Xu Xiaodan , Han Dongwei , Geng Zhongmin , Zhang Xiaoyan , Usman Muhammad 
Published: September 2017

AbstractIn this paper, a thermo- and pH-responsive microfiltration membrane was prepared based on three-dimensional (3D) inverse colloidal crystals (ICC). To manufacture the smart ICC membrane, the typical thermo-responsive N-isopropylacrylamide (NIPAM) and pH-responsive methacrylic acid (MAA) were polymerized inside silica colloidal crystals. The smart ICC membranes were characterized by SEM, IR and contact angle measurements. Moreover, the permeability of smart microfiltration membrane was carried out by the KCl diffusion tests. The result showed that effective diameter of the polymer ICC membrane can be reversible tuned by temperature and pH. Besides, the functional ICC membrane showed outstanding temperature- and pH-responsive gating property, which was applied to separate particles of different sizes. The savvy environment-responsive gating membranes have potential uses in filtration, separation, purification, sensor and other applications.