bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transition‐Metal‐Free Oxidative C(sp2)−H Hydroxylation of Terpyridines: A HOMO‐Raising Strategy for the Construction of a New Super‐Stable Terpyridine Chromophores
Authors: Huang Jiang‐Bo , Bai Xing‐Feng , Li Li , Zheng Zhan‐Jiang , Xu Zheng , Cui Yu‐Ming , Cao Jian , Xu Li‐Wen 
Published: February 2017

AbstractDirect functionalization of terpyridines is an increasingly important topic in the field of dyes and catalysis as well as supramolecular chemistry, but its synthesis and transformation is usually challenging. Herein, a HOMO‐raising strategy is reported for the construction of a super‐stable novel terpyridine chromophores, in which the selective oxidation of terpyridines at its 3‐position was determined successfully to the synthesis of phenol‐functionalization of terpyridines (TPyOHs) bearing a hydrogen bonding group. The corresponding TPyOHs displayed strong aggregation‐induced emission and exhibited highly selective and visual detection of ZnII cation with a record green terpyridine‐based luminophore with nanomolar sensitivity (125 nm).
The Influence of Supporting Ions on the Electrochemical Detection of Individual Silver Nanoparticles: Understanding the Shape and Frequency of Current Transients in Nano‐impacts
Authors: Krause Kay J. , Brings Fabian , Schnitker Jan , Kätelhön Enno , Rinklin Philipp , Mayer Dirk , Compton Richard G. , Lemay Serge G. , Offenhäusser Andreas , Wolfrum Bernhard 
Published: February 2017

AbstractWe report the influence of electrolyte composition and concentration on the stochastic amperometric detection of individual silver nanoparticles at microelectrode arrays and show that the sensor response at certain electrode potentials is dependent on both the conductivity of the electrolyte and the concentration of chloride ions. We further demonstrate that the chloride concentration in solution heavily influences the characteristic current spike shape of recorded nanoparticle impacts: While typically too short to be resolved in the measured current, the spike widths are significantly broadened at low chloride concentrations below 10 mm and range into the millisecond regime. The analysis of more than 25 000 spikes reveals that this effect can be explained by the diffusive mass transport of chloride ions to the nanoparticle, which limits the oxidation rate of individual silver nanoparticles to silver chloride at the chosen electrode potential.
CFD as a Design Tool for Fixed‐Bed Reactors with Small Tube‐to‐Pellet Diameter Ratio: Now or in the Future?
Authors: Wehinger Gregor D. , Kraume Matthias 
Published: February 2017

AbstractFestbettreaktoren mit kleinem Rohr‐zu‐Pelletdurchmesser‐Verhältnis (D/dp = N) finden vor allem bei stark exo‐ oder endothermen Reaktionen Anwendung. In diesem Beitrag werden Aspekte eines Algorithmus‐basierten Ansatzes untersucht, der Festbetten mit kleinem N ortsaufgelöst modelliert. Dabei wird das Modell hinsichtlich Bettmorphologie und den daraus resultierenden Geschwindigkeiten, Wärmetransport sowie heterogener Katalyse mit experimentellen Daten verglichen. Schlussendlich wird der Frage nachgegangen, in wie weit CFD als Designtool für Festbettreaktoren mit kleinem N verwendet werden kann.
Medicinal Chemistry Profiling of Monocyclic 1,2‐Azaborines
Authors: Zhao Peng , Nettleton David O. , Karki Rajeshri G. , Zécri Frédéric J. , Liu Shih‐Yuan 
Published: February 2017

AbstractThe first examples of biologically active monocyclic 1,2‐azaborines have been synthesized and demonstrated to exhibit not only improved in vitro aqueous solubility in comparison with their corresponding carbonaceous analogues, but in the context of a CDK2 inhibitor, also improved biological activity and better in vivo oral bioavailability. This proof‐of‐concept study establishes the viability of monocyclic 1,2‐azaborines as a novel pharmacophore with distinct pharmacological profiles that can help address challenges associated with solubility in drug development research.
Effect of postoperative radiotherapy on survival for surgically managed pT3N0 and pT4aN0 laryngeal cancer: Analysis of the National Cancer Data Base
Authors: Graboyes Evan M. , Zhan Kevin Y. , Garrett‐Mayer Elizabeth , Lentsch Eric J. , Sharma Anand K. , Day Terry A. 
Published: February 2017

BACKGROUNDThe current study was conducted to determine the effect of postoperative radiotherapy (PORT) on overall survival in patients with surgically managed pT3‐T4aN0 laryngeal squamous cell carcinoma (SCC).METHODSA review of the National Cancer Data Base from 2004 through 2013 was performed. Patients with surgically managed pT3‐4aN0 laryngeal SCC with negative surgical margins were included. Univariable and multivariable Cox regression analyses were used to determine factors associated with survival.RESULTSA total of 1460 patients were included, 46.2% of whom had pT3N0 disease (674 patients) and 53.8% of whom had pT4aN0 disease (786 patients). Approximately 72.0% of the patients with pT3N0 disease (485 patients) and 50.1% of the patients with pT4aN0 disease (394 patients) received PORT. PORT was not found to be associated with improved overall survival on univariable analysis for patients with pT3N0 disease (hazard ratio [HR], 0.84; 95% confidence interval [95% CI], 0.62‐1.14), but was for patients with pT4aN0 disease (HR, 0.57; 95% CI, 0.45‐0.71). For patients with pT3N0 SCC of the larynx, in a multivariable Cox regression analysis adjusting for age >65 years, severity of comorbidities, larynx subsite, extent of laryngectomy, and number of lymph nodes removed, PORT was not found to be associated with improved survival (adjusted HR, 0.88; 95% CI, 0.64‐1.21). For patients with pT4aN0 disease, the administration of PORT was associated with improved survival on multivariable analysis adjusting for age >65 years, severity of comorbidities, larynx subsite, number of lymph nodes removed, and type of hospital (adjusted HR, 0.58; 95% CI, 0.46‐0.73).CONCLUSIONSFor patients with surgically managed pT3N0 laryngeal SCC with negative margins, PORT does not appear to be associated with improved survival. Despite a survival benefit, nearly 50% of patients with pT4aN0 laryngeal SCC and negative surgical margins do not receive standard‐of‐care PORT. Cancer 2017;123:2248–2257. © 2017 American Cancer Society.
Racial disparities in BRCA testing and cancer risk management across a population‐based sample of young breast cancer survivors
Authors: Cragun Deborah , Weidner Anne , Lewis Courtney , Bonner Devon , Kim Jongphil , Vadaparampil Susan T. , Pal Tuya 
Published: February 2017

BACKGROUNDBreast cancer (BC) disparities may widen with genomic advances. The authors compared non‐Hispanic white (NHW), black, and Hispanic BC survivors for 1) cancer risk‐management practices among BRCA carriers and 2) provider discussion and receipt of genetic testing.METHODSA population‐based sample of NHW, black, and Hispanic women who had been diagnosed with invasive BC at age 50 years or younger from 2009 to 2012 were recruited through the state cancer registry. Multiple logistic regression was used to compare cancer risk‐management practices in BRCA carriers and associations of demographic and clinical variables with provider discussion and receipt of testing.RESULTSOf 1622 participants, 159 of 440 (36.1%) black women, 579 of 897 (64.5%) NHW women, 58 of 117 (49.6%) Spanish‐speaking Hispanic women, and 116 of 168 (69%) English‐speaking Hispanic women underwent BRCA testing, of whom 90 had a pathogenic BRCA mutation identified. Among BRCA carriers, the rates of risk‐reducing mastectomy and risk‐reducing salpingo‐oophorectomy were significantly lower among black women compared with Hispanic and NHW women after controlling for clinical and demographic variables (P = .025 and P = .008, respectively). Compared with NHW women, discussion of genetic testing with a provider was 16 times less likely among black women (P < .0001) and nearly 2 times less likely among Spanish‐speaking Hispanic women (P = .04) after controlling for clinical and sociodemographic factors.CONCLUSIONSThe current results suggest that the rates of risk‐reducing salpingo‐oophorectomy are lower among black BRCA carriers compared with their Hispanic and NHW counterparts, which is concerning because benefits from genetic testing arise from cancer risk‐management practice options. Furthermore, lower BRCA testing rates among blacks may partially be because of a lower likelihood of provider discussion. Future studies are needed to improve cancer risk identification and management practices across all populations to prevent the widening of disparities. Cancer 2017;123:2497–05. © 2017 American Cancer Society.
Psychometric properties of the Dutch version of the Treatment Support Measure (TSM) parent and youth form
Authors: van Sonsbeek Maartje A. M. S. , Holtmaat Catharina J. M. , Tiemens Bea G. , Hutschemaekers Giel J. M. , de Jong Kim 
Published: February 2017

The Treatment Support Measure (TSM) Parent and Youth were created to help clinicians with actionable feedback when youths are not making sufficient progress in treatment. This study examined the psychometric properties of the Dutch TSM Parent and TSM Youth. Parents (n = 172) and youth (n = 122) were recruited at 2 outpatient mental health care institutions. Children of participating parents (50.6% boys) had a mean age of 11.9 years (SD = 3.46; range 4–18). Participating youth (30.3% boys) had a mean age of 15.68 years (SD = 1.75; range 12–18). Participants were asked to complete the TSM and questionnaires measuring related constructs once during treatment. Responses to the TSM Parent items were explained by 9 instead of 5 subscales, and responses to the TSM Youth items were explained by 8 instead of 4 subscales. The internal consistency reliability of both the TSM Parent and the TSM Youth scales was generally good. The convergent validity of the TSM Parent and the TSM Youth was also good, although the divergent validity was less convincing. The criterion validity was inconclusive; the TSM Parent was not able to differentiate between problematic and nonproblematic treatments, but multiple scales of the TSM Youth were able to differentiate between these groups. The TSM Parent and TSM Youth have potential to be helpful tools in clinical practice. They could signal potential barriers to youth progress and direct the conversation between the clinician and youth and parents about adaptation of treatment.Key practitioner message

This is the first study to investigate the psychometric properties of the Treatment Support Measure (TSM) Parent and Youth versions, which are created to help clinicians with actionable feedback when youths are not making sufficient progress in treatment.
The Dutch TSM Parent and TSM Youth have moderate to good psychometric properties.
The Dutch TSM Parent and TSM Youth might be helpful tools for use in clinical practice: they contain variables that are related to youth outcome, can signal potential barriers to youth progress, and can direct the conversation between the clinician and the youth and parents about adaptation of treatment.
The Dutch TSM Parent and TSM Youth could be added to the regular ROM to facilitate both routine monitoring of outcome and direct and concrete aid to the here‐and‐now relational processes in treatment.
Tissue mechanics during temporal summation of sequentially cuff pressure‐induced pain in healthy volunteers and patients with painful osteoarthritis
Authors: Manafi‐Khanian B. , Kjær Petersen K. , Arendt‐Nielsen L. 
Published: February 2017

AbstractBackgroundThe phenomenon of temporal summation to repetitive pressure pain stimuli is an important central neural mechanism for pain intensity encoding. This study evaluated the time‐dependent behaviour of mechanical characteristics of soft tissue during repeated cuff stimulation used for eliciting temporal summation of cuff pressure‐evoked pain. Such information of tissue mechanics is important for the interpretation of the pain response evoked during sequential stimulations.MethodsTemporal summation was assessed in 16 subjects separated into two groups (healthy controls and severe knee osteoarthritis patients) using a visual analogue scale during 10 repetitive painful cuff stimuli (1‐s duration, 1‐s break) of the lower leg. The geometry of the lower leg was constructed based on magnetic resonance image (MRI) data. The loading boundary condition of the finite element model was defined according to the parabolic pattern of the interface pressure around the limb and the time‐dependent profile of the cuff pressure during repetitive stimuli.ResultsThe pain intensity significantly increased with an increasing number of stimuli (p < 0.001), and facilitated temporal summation of pain was observed in patients compared with healthy controls (p < 0.001). The maximal deep tissue stress and strain during stimuli 1–4 varied 43% and 9%, respectively. No variation was observed for stimuli 5–10.ConclusionsThe study concludes that the temporal summation of pain response during sequential cuff pressure is not explicable by a specific time‐dependent behaviour of stress and strain in the activated deep tissue and hence not due to changes in tissue biomechanics.SignificanceThe temporal summation of pain during sequential cuff stimulation is inexplicable by the time‐dependent response of mechanical stress and strain in soft tissue.
Electrochemical Characterizations of four Main Redox–metabolites of Pseudomonas Aeruginosa
Authors: Oziat Julie , Gougis Maxime , Malliaras George G. , Mailley Pascal 
Published: February 2017

AbstractBacterial identification is of first importance in clinic nowadays. For few years, electrochemistry appears as a reliable route for characterizations outside of laboratories. Nowadays, researchers mainly focus on the opportunistic pathogen Pseudomonas aeruginosa because of its production of the Pyocyanin toxin which has an electrochemical case study behavior. Other P. aeruginosa secreted molecules are also studied in a lesser extent. This work deals with the systematic electrochemical characterizations in aprotic and protic solvents of 4 main metabolites of this bacterium in the view of multispecies detection of P. aeruginosa. We report here the behavior of the 2‐Heptyl‐4(1H)‐quinolone (HHQ), Pseudomonas Quinolone Signal (PQS), Pyocyanin (PYO) and the 2′aminoacetophenone (2‐AA). All the mentioned species are clearly visible by using electrochemical techniques (cyclic and square wave voltammetries). The 2 most suitable species for electrochemical detection appear to be PQS and PYO because of their detection at low potential.
Electrochemical Detection of FAM134B Mutations in Oesophageal Cancer Based on DNA‐Gold Affinity Interactions
Authors: Haque Md. Hakimul , Islam Md. Nazmul , Islam Farhadul , Gopalan Vinod , Nguyen Nam‐Trung , Lam Alfred K. , Shiddiky Muhammad J. A. 
Published: February 2017

AbstractInexpensive, simple and rapid DNA sensors capable of accurate and sensitive detection of cancer specific point mutations in DNA biomarkers are crucial for the routine screening of genetic mutations in cancer. Conventional approaches based on sequencing, mass spectroscopy, and fluorescence are highly effective, but they are tedious, slow and require labels and expensive equipment. Recent electrochemistry based approaches mostly rely on conventional DNA biosensing using recognition and transduction layers, and hence limited by the complicated steps of sensor fabrication associated with surface cleaning, self‐assembled monolayer formation, and target hybridization. Herein we report a relatively simple and inexpensive method for detecting point mutation in cancer by using the direct adsorption of purified DNA sequences onto an unmodified gold surface. The method relies on the base dependent affinity interaction of DNA with gold. Since the affinity interaction (adsorption) trend of DNA bases follows as adenine (A) > cytosine (C) > guanine (G)> thymine (T), two DNA sequences with different DNA base compositions (i. e., amplified mutated sequences will be distinctly different than its original sequence) will have different adsorption affinity towards gold. The amount of mutation sites on a DNA sequence is quantified by monitoring the electrochemical current as a function of the relative adsorption level of DNA samples onto a bare gold electrode. This method can successfully distinguish single point mutation in DNA from oesophageal cancer. We demonstrated the clinical utility of this approach by detecting different levels of mutations in tissue samples (n=9) taken from oesophageal cancer patients. Finally, the method was validated with High Resolution Melt (HRM) curve analysis and Sanger Sequencing.
Optimization of the extraction of the p‐menthadienol isomers and aristolone contained in the essential oil from Elyonurus hensii using a 23 full factorial design
Authors: Loumouamou Aubin Nestor , Bikindou Kévin , Bitemou Ernest , Chalard Pierre , Silou Thomas , Figueredo Gilles 
Published: February 2017

AbstractThe aim of this study was to optimize the extraction of p‐menthadienol isomers and aristolone from the essential oil of Elyonurus hensii by hydrodistillation. The study of the seasonal variation in the chemical composition has shown that the plant material has been subject to a natural selection regarding the biosynthesis of the p‐menthadienol isomers: during periods of water stress, the extracts are rich in cis and trans‐p‐mentha‐1(7),8‐dien‐2‐ol and poor in cis and trans‐p‐mentha‐2,8‐dien‐1‐ol. Regarding the modeling, eight experiments were carried out by considering three easily interpretable factors (the extraction duration, the residual water content and the state of the division of the plant material). The average yield was 1.33% for the aerial part and 0.74% for the roots. The residual water content is the most important factor, which significantly influences the average yield of the essential oil and the content of the major constituents. Regarding the aerial part, a low residual water content of the plant material varies the essential oil yield (from 0.40% to 2.11%) and the content of cis and trans‐p‐mentha‐2.8‐dien‐1‐ol (from 15.87% to 23.24%). At the root level, the samples that have a very low residual water content provide extracts richer in aristolone. The combined effects of the extraction duration, the state of division, and the residual water content influence greatly the extraction of aristolone (from 36.68% to 54.55%). However, these interactions are more complex and difficult to assess.
Phospholipid localization implies microglial morphology and function via Cdc42 in vitro
Authors: Tokizane Kyohei , Konishi Hiroyuki , Makide Kumiko , Kawana Hiroki , Nakamuta Shinichi , Kaibuchi Kozo , Ohwada Tomohiko , Aoki Junken , Kiyama Hiroshi 
Published: February 2017

AbstractUnder a quiescent state, microglia exhibit a ramified shape, rather than the amoeboid‐like morphology following injury or inflammation. The manipulation of microglial morphology in vitro has not been very successful, which has impeded the progress of microglial studies. We demonstrate that lysophosphatidylserine (LysoPS), a kind of lysophospholipids, rapidly and substantially alters the morphology of primary cultured microglia to an in vivo‐like ramified shape in a receptor independent manner. This mechanism is mediated by Cdc42 activity. LysoPS is incorporated into the plasma membrane and converted to phosphatidylserine (PS) via the Lands' cycle. The accumulated PS on the membrane recruits Cdc42. Both Cdc42 and PS colocalize predominantly in primary and secondary processes, but not in peripheral branches or tips of microglia. Along with the morphological changes LysoPS suppresses inflammatory cytokine production and NF‐kB activity. The present study provides a tool to manipulate a microglial phenotype from an amoeboid to a fully ramified in vitro, which certainly contributes to studies exploring microglial physiology and pathology.
The impact of wildfire on baseflow recession rates in California
Authors: Bart Ryan R. , Tague Christina L. 
Published: February 2017

AbstractThe effect of wildfire on peak streamflow and annual water yield has been investigated empirically in numerous studies. The effect of wildfire on baseflow recession rates, in contrast, is not well documented. The objective of this paper was to quantify the effect of wildfire on baseflow recession rates in California for both individual watersheds and for all the study watersheds collectively. Two additional variables, antecedent groundwater storage and potential evapotranspiration, were also investigated for their effect on baseflow recession rates and postfire baseflow recession rate response. Differences between prefire and postfire baseflow recession rates were modeled statistically in 8 watersheds using a mixed statistical model that accounted for fixed and random effects. For the all‐watershed model, antecedent groundwater storage, potential evapotranspiration, and wildfire were each found to be significant controls on baseflow recession rates. Wildfire decreased baseflow recession rates 52.5% (37.6% to 66.0%), implying that postfire reductions in above‐ground vegetation (e.g., decreased interception, decreased evapotranspiration) were a stronger control on baseflow recession rate change than hydrophobicity. At an individual watershed scale, baseflow recession rate response to wildfire was found to be sensitive to intraannual differences in antecedent groundwater storage in 2 watersheds, with the effect of wildfire on baseflow recession rates being greater with lower levels of antecedent groundwater storage. Examination of burn severity for a subset of the study watersheds pointed to riparian zone burn severity as a potential primary control on postfire recession rate change. This study demonstrates that wildfire may have a substantial impact on fluxes to and from groundwater storages, altering the rate at which baseflow recedes.
Transthoracic echocardiography study of congenitally corrected transposition of the great arteries
Authors: Singh Amarjit , Singh Gurpreet , Dhaliwal Tejveer S. , Singh Manpreet 
Published: February 2017

ABSTRACTCongenitally corrected transposition of the great arteries (CCTGA) is a rare congenital heart defect, occurring in only 0.5% of patients exhibiting congenital heart defects. Because it is not seen in a routine transthoracic echocardiography (TTE) examination, CCTGA may be missed. The echocardiography diagnosis of CCTGA is difficult and not well explained in most textbooks. The present report provides key sonographic images that contribute to the diagnosis. In the present case, the patient had no prior history of heart disease. TTE revealed that the patient had CCTGA and early tricuspid regurgitation with right ventricle enlargement and hypertrophy. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:375–379, 2017;