bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing the Diagnosis and Management of Pediatric Inducible Laryngeal Obstruction
Authors: Alanazi Alaa , Aizouki Carolin , Sloychuk Janelle , Callaghan Amy , Eksteen Eduard , Ennis Sheila , Isaac Andre 
Published: October 2024

BackgroundPediatric inducible laryngeal obstruction (ILO) is difficult to diagnose and treat. Patients often undergo multiple specialist referrals, and long‐term outcomes are not well reported.ObjectivesTo investigate the patterns of presentation, workup, and management of children who were diagnosed with ILO at the Stollery Children's Hospital.MethodsRetrospective review with a prospective cohort of pediatric patients diagnosed with ILO from 2015 to 2023. We collected the demographic data, diagnostic tests, specialist referrals, time to diagnosis, symptom burden, associated comorbidities and aggravating factors, management, and treatment outcomes. A subset of patients was followed prospectively to determine treatment outcomes. A basic descriptive analysis was performed, and factors associated with time to resolution were studied.ResultsSeventy‐eight patients met the criteria for inclusion, with 22 completing prospective questionnaires. The average age was 14 years old, and 75% were female. The majority required multiple specialist referrals. The majority were associated with exercise. Thirty‐two (41%) patients had a presumed diagnosis of asthma, despite only four pulmonary function tests being consistent with asthma. Abortive breathing exercises were the most commonly employed (95%) and most successful (61%) nonsurgical management technique. Surgery was highly successful in a small cohort of patients. Median time to symptom resolution was 12 months, with 36% reporting symptoms persistent beyond 3 years.ConclusionsPediatric ILO often goes undiagnosed for prolonged periods. Exercise‐related symptoms are the most common. Management strategies have varied levels of success and a large proportion of patients have prolonged symptoms despite treatment, as supported by other recent evidence.Level of Evidence3 Laryngoscope, 135:1207–1211, 2025
Primary Site Influences the Ability of Magnetic Resonance Imaging to Assess Cartilage Invasion in Advanced Laryngeal Cancer
Authors: Hintze Justin M. , Cleere Eoin , Griffin J. , O'Riordan I. , Timon C. , Kinsella J. , Fitzgerald C. , Lennon P. 
Published: October 2024

ObjectiveAccurate staging of advanced laryngeal cancer is important, as treatment can vary significantly between larynx preservation and total laryngectomy. The purpose of this study was to evaluate the accuracy of magnetic resonance imaging (MRI) in assessing features of T4a disease in locally advanced laryngeal cancer and determine if primary site played a role in the accuracy of MRI in this setting.MethodsA retrospective cohort study of patients undergoing a total laryngectomy in a tertiary referral center for head and neck cancer over a 10‐year time period was carried out. Patients met inclusion criteria if they underwent a primary total laryngectomy for squamous cell carcinoma (SCC) of the larynx during the study period. Data collected included basic demographic data, primary tumor subsite, and clinical and pathological staging. The predictive ability of MRI on outer thyroid cortex invasion, extralaryngeal extension, and overall T4a stage was analyzed with receiver operating characteristics analysis. Analysis was compared to histological data on outer thyroid cortex invasion, extralaryngeal extension, and histological T4a stage.ResultsA total of 112 patients met inclusion criteria. The mean age of the cohort was 65.1. Glottic primary subsite was associated with a statistically significant elevated risk for histological outer cortex erosion (p = 0.006), but MRI demonstrated worse sensitivity in detecting this outer cortex invasion in glottic primaries(p = 0.002).ConclusionGlottic primaries tumors display an increased likelihood of thyroid cartilage invasion, however, MRI demonstrates a poorer sensitivity for detecting these features.Level of Evidence3 Laryngoscope, 135:723–728, 2025
Pediatric Huntington Disease Brains Have Distinct Morphologic and Metabolic Traits: the RAREST‐JHD Study
Authors: Caligiuri Maria Eugenia , Tinelli Emanuele , Vizza Patrizia , Giancaterino Giulia , Cicone Francesco , Cascini Giuseppe Lucio , Sabatini Umberto , Squitieri Ferdinando 
Published: October 2024

ABSTRACTBackgroundPediatric‐onset Huntington's disease (POHD) exhibits a phenotype different from adult‐onset HD (AOHD), with hypokinetic movement disorders (eg, rigidity, bradykinesia, and dystonia) rather than chorea typical of AOHD.ObjectivesThe aim was to identify pathophysiology‐based biomarkers specific to POHD (≥60 CAG repeats).MethodsSimultaneous hybrid imaging using [18F]fluoro‐2‐deoxy‐d‐glucose (FDG) positron emission tomography plus magnetic resonance imaging (FDG‐PET/MRI) and clinical assessment using standardized Huntington's disease (HD) scales were employed. Exploratory longitudinal analyses were also performed.ResultsStriatal volume loss was remarkable and more severe in POHD (n = 5) than in AOHD (n = 14). Widespread, significantly altered glucose metabolism occurred in several different POHD cortical areas and thalamus, but not AOHD cortex, consistent with differences in clinical progression.ConclusionsPOHD patients' brains exhibited distinct morphologic and metabolic traits compared to AOHD patients’ brains, with longitudinal changes mirroring clinical progression. Hybrid FDG‐PET/MRI highlighted a variable regional brain dysfunction in vivo, as a biological consequence of highly expanded CAG repeats. Findings provide further evidence that POHD is a distinct disease from AOHD.
Coffee Bioactive N‐Methylpyridinium: Unveiling Its Antilipogenic Effects by Targeting De Novo Lipogenesis in Human Hepatocytes
Authors: Giannotti Laura , Stanca Eleonora , Di Chiara Stanca Benedetta , Spedicato Francesco , Massaro Marika , Quarta Stefano , Del Rio Daniele , Mena Pedro , Siculella Luisa , Damiano Fabrizio 
Published: October 2024

ScopeType 2 diabetes and nonalcoholic fatty liver diseases (NAFLDs) are promoted by insulin resistance (IR), which alters lipid homeostasis in the liver. This study aims to investigate the effect of N‐methylpyridinium (NMP), a bioactive alkaloid of coffee brew, on lipid metabolism in hepatocytes.Methods and resultsThe effect of NMP in modulating lipid metabolism is evaluated at physiological concentrations in a diabetes cell model represented by HepG2 cells cultured in a high‐glucose medium. Hyperglycemia triggers lipid droplet accumulation in cells and enhances the lipogenic gene expression, which is transactivated by sterol regulatory element binding protein‐1 (SREBP‐1). Lipid droplet accumulation alters the redox status and endoplasmic reticulum (ER) stress, leading to the activation of the unfolded protein response and antioxidative pathways by X‐Box Binding Protein 1(XBP‐1)/eukaryotic Initiation Factor 2 alpha (eIF2α) Protein Kinase RNA‐Like ER Kinase and nuclear factor erythroid 2‐related factor 2 (NRF2), respectively. NMP induces the phosphorylation of AMP‐dependent protein kinase (AMPK) and acetyl‐CoA carboxylase α (ACACA), and improves the redox status and ER homeostasis, essential steps to reduce lipogenesis and lipid droplet accumulation.ConclusionThese results suggest that NMP may be beneficial for the management of T2D and NAFLD by ameliorating the cell oxidative and ER homeostasis and lipid metabolism.
Whole‐brain T2 mapping with radial sampling and retrospective motion correction at 3T
Authors: Corbin Nadège , Trotier Aurelien J. , Anandra Serge , Kadalie Emile , Dallet Laurence , Miraux Sylvain , Ribot Emeline J. 
Published: October 2024

AbstractPurposeSeveral barriers prevent the use of whole‐brain T2 mapping in routine use despite increasing interest in this parameter. One of the main barriers is the long scan time resulting in patient discomfort and motion corrupted data. To address this challenge, a method for accurate whole‐brain T2 mapping with a limited acquisition time and motion correction capabilities is investigated.MethodsA 3D radial multi‐echo spin‐echo sequence was implemented with optimized sampling trajectory enabling the estimation of intra‐scan motion, subsequently used to correct the raw data. Motion corrected echo images are then reconstructed with linear subspace constrained reconstruction. Experiments were carried out on phantom and volunteers at 3T to evaluate the accuracy of the T2 estimation, the sensitivity to lesions and the efficiency of the correction on motion corrupted data.ResultsWhole‐brain T2 mapping acquired in less than 7 min enabled the depiction of lesions in the white matter with longer T2. Data retrospectively corrupted with typical motion traces of pediatric patients highly benefited from the motion correction by reducing the error in T2 estimates within the lesions. All datasets acquired on seven volunteers, with deliberate motion, also showed that motion corrupted T2 maps could be improved with the retrospective motion correction both at the voxel level and the structure level.ConclusionA whole‐brain T2 mapping sequence with retrospective intra‐scan motion correction and reasonable acquisition time is proposed. The method necessitates advanced iterative reconstruction strategies but no additional navigator, external device, or increased scan time is required.
Is it Possible to Regenerate the Underactive Detrusor? Part 2 Electrical Stimulation Therapies, Treatment of Bladder Outlet Obstruction, Constipation, and Pelvic Floor Disorders ICI‐RS 2024
Authors: Sinha Sanjay , Gajewski Jerzy B. , Tarcan Tufan , Van Huele Andries , Cruz Francisco , Martinez Esther M. , Przydacz Mikolaj , Bou Kheir George , Lombardo Riccardo , Wein Alan , Abrams Paul 
Published: October 2024

ABSTRACTIntroductionDetrusor muscle weakness is commonly noted on urodynamics in patients with refractory voiding difficulty. No clinical therapy has been proven to augment the strength of a detrusor contraction.MethodsThis subject was discussed at a think‐tank at the International Consultation on Incontinence‐Research Society (ICI‐RS) held in Bristol, June 2024. The discussions of the think‐tank are being published in two parts. This second part discusses the role of electrical stimulation therapies, treatment of bladder outlet obstruction, constipation, and pelvic floor disorders, in the enhancement of strength of a detrusor contraction.ResultsElectrical stimulation therapies, specifically sacral neuromodulation, have long been used in the salvage of patients with refractory nonobstructive voiding dysfunction. Clinical improvements can be noted in men following bladder outlet resistance reduction surgery especially, though not limited to those with demonstrable obstruction. Some patients may also show improvement with pelvic floor relaxation therapies and constipation care. However, there is a lack of high‐quality urodynamic data to demonstrate an improvement in the strength of a detrusor contraction with these therapies. The think‐tank recommends standards for future clinical studies examining treatments aimed at improving an underactive detrusor.ConclusionsStudies need to examine whether clinical improvement following treatment of patients with an underactive detrusor is associated with improvement in strength of the detrusor contraction. New therapeutic options should apply specified standards for assessing and reporting the impact on detrusor contraction.
Evolution of the “Hierarchy of Engagement” Model Over a Decade: Examining Social Media Use to Inform, Activate, and Create Community
Authors: Noor Zeeshan , Hersey Leigh 
Published: October 2024

ABSTRACTThe use and underuse of social media by organizations have garnered significant attention from scholars. The findings indicate that most public and nonprofit organizations primarily use one‐way messaging in their social media communication. In 2012, Lovejoy and Saxton presented a “Hierarchy of Engagement” framework to categorize nonprofits' social media communication into Information, Community, and Action (ICA) messages. Since its publication, more than 100 research articles, reports, etc. have referred to this framework. This study presents a systematic review of 48 published scholarly articles that applied and expanded the ICA typology over 10 years (2012–2021). We find that the messaging strategy has not changed much from how the authors initially framed it. The social media accounts reviewed by this literature average share 51% information, 24% community, and 26% action messages. This study offers practical implications for nonprofit professionals, marketers, digital media managers, and scholars.
Roles of pediatric surgeons in palliative pediatric oncology
Authors: Le Hau D. , Braungart Sarah , Shalkow‐Klincovstein Jaime , Piché Nelson 
Published: October 2024

AbstractPediatric surgeons engaged in oncology will inevitably treat patients receiving palliative care, but their role in this context is poorly described. This article identifies some of the challenges and opportunities of surgical involvement in pediatric oncology palliative care, underscoring how the surgeon's expertise can be exploited to significantly benefit children with cancer. Specific examples of skills (procedural, communication, and coordination) that surgeons can provide to the multidisciplinary palliative care teams are described and the importance of collaboration is highlighted.
GABA promotes peroxisome proliferation in Triticum monococcum leaves
Authors: Şahin Yunus , Nazarov Taras , Ünlü Ercan Selçuk , Smertenko Andrei , Zencrici Nusret 
Published: October 2024

AbstractAlthough peroxisomes are integral for both primary and secondary metabolism, how developmental changes affect activity of peroxisomes remains poorly understood. Here, we used published RNA‐seq data to analyze the expression patterns of genes encoding 21 peroxisome metabolic pathways at successive developmental stages of Zea mays and Oryza sativa. Photorespiration was the most represented pathway in adult leaf relative to the juvenile stages. Components of reactive oxygen species (ROS)/reactive nitrogen species (RNS) metabolism, NADPH regeneration, and catabolism of polyamines were also enriched at later stages of leaf differentiation. The most commonly upregulated gene in differentiated leaves across all datasets of both species was BETAINE ALANINE DEHYDROGENASE (BADH). BADH functions in catabolism of polyamines where it converts 4‐aminobutyraldehyde (ABAL) to 4‐aminobutyrate (GABA). We tested the outcome of RNA‐seq analysis by qRT‐PCR in developing Triticum monococcum ssp. monococcum (Einkorn) seedlings. Consistent with the outcomes of RNA‐seq analysis, transcription of BADH and CATALASE3 (CAT3) were upregulated in older seedlings. CAT3 is an essential peroxisome biogenesis factor and a key enzyme of ROS homeostasis. Furthermore, exogenous application of GABA resulted in higher peroxisome abundance and transcriptional upregulation of BADH and a gene encoding another peroxisome biogenesis factor responsible for peroxisome fission, PEROXIN11C (PEX11C), in leaves. We propose that GABA contributes to regulation of peroxisome fission machinery during leaf differentiation.
Tricuspid annular plane systolic excursion to pulmonary artery systolic pressure ratio in chronic thromboembolic pulmonary hypertension improves with balloon pulmonary angioplasty
Authors: Yang Jenny Z. , Poch David S. , Ang Lawrence , Mahmud Ehtisham , Bautista Marie Angela , Alotaibi Mona , Fernandes Timothy M. , Kerr Kim M. , Papamatheakis Demosthenes G. , Kim Nick H. 
Published: October 2024

AbstractRight ventricle (RV)‐to‐pulmonary artery (PA) coupling measured by the ratio of echocardiography‐derived tricuspid annular plane systolic excursion (TAPSE) and pulmonary artery systolic pressure (PASP) is a meaningful prognostic marker in pulmonary hypertension (PH). It's unclear if balloon pulmonary angioplasty (BPA) treatment of chronic thromboembolic pulmonary hypertension (CTEPH) alters RV‐PA coupling measured by TAPSE/PASP. We reviewed CTEPH patients treated with BPA at our institution who had a transthoracic echocardiogram (TTE) before BPA and a follow‐up TTE at any point during BPA. TAPSE was obtained from the initial and lattermost TTE; hemodynamics were obtained before each BPA session. Between March 2015 to October 2023, there were 228 patients treated with BPA. After excluding post‐PTE patients and those without PH, 67 were included. Initial TAPSE/PASP was 0.39 ± 0.21 mm/mmHg. Using previously defined TAPSE/PASP tertiles in PH (<0.19, 0.19–0.32, >0.32 mm/mmHg), there were 6 patients (9%) in low, 30 (45%) in middle, and 31 (46%) in the high tertiles at baseline. The lower TAPSE/PASP tertiles had more severe baseline hemodynamics (p < 0.001) compared to the high TAPSE/PASP cohort. At follow‐up, TAPSE/PASP improved to 0.47 ± 0.20 mm/mmHg (p = 0.023), with 2 (3%), 13 (19%), and 52 (78%) patients in the low, middle, high TAPSE/PASP tertiles, respectively. As patients progress through BPA sessions, the TAPSE/PASP ratio increases, possibly reflecting improved RV mechanics and RV‐PA coupling. TAPSE/PASP ratio as a marker of RV‐PA coupling can improve with BPA treatment and may be an important measure to follow during treatment of CTEPH.
Luteolin‐Loaded Hyaluronidase Nanoparticles with Deep Tissue Penetration Capability for Idiopathic Pulmonary Fibrosis Treatment
Authors: Pan Bo , Wu Fangping , Lu Shanming , Lu Wenwen , Cao Jiahui , Cheng Fei , Ou Meitong , Chen Youyi , Zhang Fan , Wu Guolin , Mei Lin 
Published: October 2024

AbstractIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by sustained fibrotic lesions. Orally administered drugs usually fail to efficiently penetrate the interstitial tissue and reach the lesions, resulting in low treatment efficiency. Luteolin (Lut) is a natural flavonoid, active metabolites of which possess antioxidant, anti‐inflammatory, anti‐fibrotic, and anti‐apoptotic properties. In this study, a nano‐formulation is developed by loading Lut into hyaluronidase nanoparticles (Lut@HAase). These Lut@HAase nanoparticles (NPs) exhibit small size and good stability, suitable for noninvasive inhalation and accumulation in the lungs, and hyaluronidase at the site of lesions can degrade hyaluronic acid in the interstitial tissue, enabling efficient penetration of Lut. Lut's therapeutic effect, when administered via NPs, is studied both in vitro (using MRC5 cells) and in vivo (using IPF mice models), and its anti‐fibrotic properties are found to inhibit inflammation and eliminate reactive oxygen species. Conclusively, this study demonstrates that Lut@HAase can improve lung function and enhance survival rates while reducing lung damage with few abnormalities during IPF treatment.
Morphologic Examination of Ossicula Auditus in Different Ruminants
Authors: Demircioğlu İsmail , Aksünger Karaavci Funda 
Published: October 2024

ABSTRACTBackgroundThe ossicula auditus is the structure that transmits vibrations from the tympanic cavity to the auris interna. This assembly is formed by three ossicles: the malleus, incus and stapes. In addition, the bone that exists as os lenticulare in humans exists as processus lenticulare in most mammals.ObjectiveTo our knowledge, no in‐depth study has been published on the ossicula auditus of gazelles. This study aims to provide a comparative study of the morphology of the auditory ossicles in sheep, goats and gazelles.MethodsOssicula auditus from six adult Awassi sheep, six hair goats and six gazelles was examined and photographed under a stereomicroscope.Results and conclusionIt was determined that the ossicula auditus of gazelle, hair goat and Awassi sheep consisted of malleus, incus and stapes. In the species examined, it was observed that the articular surface on the caput mallei, the malleus protrusions and the distal part of the manubrium mallei differed between species. It was determined that the incus bone consists of a body and two crus. As an important morphological difference, the proc. lenticulare was found to be on the crus breve in all three species. It was determined that the stapes bone was quadrangular in the species examined, especially in goats, but this quadrangular shape, which is specific to ruminants, was not fully formed in other species. As a result, it was determined that the ossicula auditus of gazelle, hair goat and Awassi sheep showed morphologically different characteristics.
Effect of Embedded Shape Memory Alloy (SMA) on the Low-velocity Impact Behaviour of Stringer Stiffened Composite Plates
Authors: Brack Tristan , Ghasemnejad Hessam 
Published: October 2024

Abstract
This study presents an analytical model of low-velocity impact on composite plates, possessing either flat or cylindrical shapes. The overall plate`s stiffness properties are varied with an additionally assembled Ω-stringer and embedded shape memory alloy wires in the composite material, using only the shape memory effect. This analytical approach enables a low-effort but sufficiently accurate design of low-energy-impacted structures. Comprehensive analytical equations are developed based on the inclusion of the stringer effect on the curved panels. For both stringer-stiffened and non-stiffened plate models, parameter variations regarding the impact and shape memory alloy (SMA) wire integration are conducted. The effects can be classified as changes in essential and acquired stiffness. Our results indicate that SMAs improve the energy absorption capability of stiffened composite panels.
Exploring Metalinguistic Awareness in School-Aged Autistic Children: Insights from Grammatical Judgment
Authors: Wolfer Pauline , Baumeister Franziska , Rudelli Nicola , Corrigan Grace , Naigles Letitia R. , Durrleman Stephanie 
Published: October 2024

AbstractMetalinguistic awareness, the ability to manipulate and reflect upon language, remains largely unexplored in the autistic population. To address this gap, this observational cross-sectional study examines the metalinguistic abilities of school-aged autistic children in comparison to neurotypical peers in a novel tablet-based Grammatical Judgment Task (GJT) of reduced linguistic complexity engaging two kinds of metacognitive resources. Children had to judge non-verbally whether pre-recorded sentences were grammatically correct or not, following the traditional GJT paradigm assessing metamorphosyntactic skills. In addition, sentences with anomalous meaning that were either grammatically correct or grammatically incorrect were introduced to test metasemantic knowledge. Findings reveal no difference in performance between the groups, with participants performing on average above chance level both on the sentences assessing mere metamorphosyntactic skills and on the sentences placing an additional demand on metasemantics. This study shows that autistic individuals are able to mobilize metalinguistic resources when tested via a task of reduced linguistic complexity.
Using information and communication technology (ICT)-based data systems to support teacher data-driven decision-making: Insights from the literature (2013–2023)
Authors: Alonzo Dennis , Quimno Val , Townend Geraldine , Oo Cherry Zin 
Published: October 2024

AbstractThe use of information and communication technology-based data systems to support teachers in data-driven decision-making (DDDM) remains limited. Despite the growing number of data systems available, their uptake remains limited, and there is a limited understanding of what data system characteristics increase and factors that influence teacher adoption and use. To address this gap, we reviewed the literature using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Synthesis of the 17 articles from three databases revealed six data systems commonly used in schools. Also, there are eight key data system characteristics that teachers find helpful. We have found several factors that influence teacher adoption of data systems related to data features, leadership, individual disposition, and the socio-cultural context. The findings of our review have critical implications for designing and using technology-based data systems for supporting teacher data-driven decision-making.