bluuebunny/crossref_metadata_2025_split huggingface dataset:
Free‐breathing abdominal MRI improved by repeated k‐t‐subsampling and artifact‐minimization (ReKAM)
Authors: Chu Mei‐Lan , Chang Hing‐Chiu , Chung Hsiao‐Wen , Bashir Mustafa R. , Cai Jing , Zhang Lei , Sun Duohua , Chen Nan‐kuei 
Published: November 2017

PurposeWe report an approach, termed Repeated k‐t‐subsampling and artifact‐minimization (ReKAM), for removing motion artifacts in free‐breathing abdominal MRI. The method is particularly valuable for challenging patients who may not hold their breath for a long time or have irregular respiratory rate.MethodsThe ReKAM framework comprises one acquisition module and two reconstruction modules. A fast MRI sequence is used to repeatedly acquire multiple sets of k‐t space data. Motion artifacts are then minimized by two reconstruction modules: (a) a bootstrapping module in k‐t‐space is used to identify a low‐artifact image; (b) a constrained reconstruction module that integrates projection onto convex set (POCS) and multiplexed sensitivity encoding (MUSE), termed POCSMUSE, is applied to further remove residual artifact. The ReKAM framework is compatible with different pulse sequences, and generally applicable to irregular data sampling patterns in k‐space. Free‐breathing fast spin‐echo MRI data, acquired from healthy volunteers and patients, were used to evaluate the developed ReKAM method.ResultsExperimental results show that the ReKAM technique can produce high‐quality free‐breathing images with the artifact levels comparable to that of breath‐holding MRI.ConclusionThe ReKAM framework improves the quality of free‐breathing abdominal MRI data, and is compatible with various MRI pulse sequences.
An inductively coupled ultra‐thin, flexible, and passive RF resonator for MRI marking and guiding purposes: Clinical feasibility
Authors: Alipour Akbar , Gokyar Sayim , Algin Oktay , Atalar Ergin , Demir Hilmi Volkan 
Published: November 2017

PurposeThe purpose of this study is to develop a wireless, flexible, ultra‐thin, and passive radiofrequency‐based MRI resonant fiducial marker, and to validate its feasibility in a phantom model and several body regions.MethodsStandard microfabrication processing was used to fabricate the resonant marker. The proposed marker consists of two metal traces in the shape of a square with an edge length of 8 mm, with upper and lower traces connected to each other by a metalized via. A 3T MRI fiducial marking procedure was tested in phantom and ex vivo, and then the marker's performance was evaluated in an MRI experiment using humans. The radiofrequency safety was also tested using temperature sensors in the proximity of the resonator.ResultsA flexible resonator with a thickness of 115 μm and a dimension of 8 × 8 mm was obtained. The experimental results in the phantom show that at low background flip angles (6–18°), the resonant marker enables precise and rapid visibility, with high marker‐to‐background contrast and signal‐to‐noise ratio improvement of greater than 10 in the vicinity of the marker. Temperature analysis showed a specific absorption ratio gain of 1.3. Clinical studies further showed a successful biopsy procedure using the fiducial marking functionality of our device.ConclusionsThe ultra‐thin and flexible structure of this wireless flexible radiofrequency resonant marker offers effective and safe MR visualization with high feasibility for anatomic marking and guiding at various regions of the body. Magn Reson Med 80:361–370, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
A multicenter, retrospective medical record review of X‐linked myotubular myopathy: The recensus study
Authors: Beggs Alan H. , Byrne Barry J. , De Chastonay Sabine , Haselkorn Tmirah , Hughes Imelda , James Emma S. , Kuntz Nancy L. , Simon Jennifer , Swanson Lindsay C. , Yang Michele L. , Yu Zi‐Fan , Yum Sabrina W. , Prasad Suyash 
Published: November 2017

ABSTRACTIntroduction: X‐linked myotubular myopathy (XLMTM), characterized by severe hypotonia, weakness, respiratory distress, and early mortality, is rare and natural history studies are few. Methods: RECENSUS is a multicenter chart review of male XLMTM patients characterizing disease burden and unmet medical needs. Data were collected between September 2014 and June 2016. Results: Analysis included 112 patients at six clinical sites. Most recent patient age recorded was ≤18 months for 40 patients and >18 months for 72 patients. Mean (SD) age at diagnosis was 3.7 (3.7) months and 54.3 (77.1) months, respectively. Mortality was 44% (64% ≤18 months; 32% >18 months). Premature delivery occurred in 34/110 (31%) births. Nearly all patients (90%) required respiratory support at birth. In the first year of life, patients underwent an average of 3.7 surgeries and spent 35% of the year in the hospital. Discussion: XLMTM is associated with high mortality, disease burden, and healthcare utilization. Muscle Nerve 57: 550–560, 2018
An International Continence Society (ICS) report on the terminology for adult neurogenic lower urinary tract dysfunction (ANLUTD)
Authors: Gajewski Jerzy B. , Schurch Brigitte , Hamid Rizwan , Averbeck Márcio , Sakakibara Ryuji , Agrò Enrico F. , Dickinson Tamara , Payne Christopher K. , Drake Marcus J. , Haylen Bernie T. 
Published: November 2017

IntroductionThe terminology for adult neurogenic lower urinary tract dysfunction (ANLUTD) should be defined and organized in a clinically based consensus Report.MethodsThis Report has been created by a Working Group under the auspices and guidelines of the International Continence Society (ICS) Standardization Steering Committee (SSC) assisted at intervals by external referees. All relevant definitions for ANLUTD were updated on the basis of research over the last 14 years. An extensive process of 18 rounds of internal and external review was involved to exhaustively examine each definition, with decision‐making by collective opinion (consensus).ResultsA Terminology Report for ANLUTD, encompassing 97 definitions (42 NEW and 8 CHANGED, has been developed. It is clinically based with the most common diagnoses defined. Clarity and user‐friendliness have been key aims to make it interpretable by practitioners and trainees in all the different groups involved not only in lower urinary tract dysfunction but additionally in many other medical specialties.ConclusionA consensus‐based Terminology Report for ANLUTD has been produced to aid clinical practice and research.
Price and capacity decisions of service systems with boundedly rational customers
Authors: Li Xin , Guo Pengfei , Lian Zhaotong 
Published: November 2017

AbstractWe consider price and capacity decisions for a profit‐maximizing service provider in a single server queueing system, in which customers are boundedly rational and decide whether to join the service according to a multinomial logit model. We find two potential price‐capacity pair solutions for the first‐order condition of the profit‐maximizing problem. Profit is maximized at the solution with a larger capacity, but minimized at the smaller one. We then consider a dynamically adjusting capacity system to mimic a real‐life situation and find that the maximum can be reached only when the initial service rate is larger than a certain threshold; otherwise, the system capacity and demand shrink to zero. We also find that a higher level of customers’ bounded rationality does not necessarily benefit a firm, nor does it necessarily allow service to be sustained. We extend our analysis to a setting in which customers’ bounded rationality level is related to historical demand and find that such a setting makes service easier to sustain. Finally we find that bounded rationality always harms social welfare.
MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB–NFIB fusion gene
Authors: Kim Jisun , Geyer Felipe C , Martelotto Luciano G , Ng Charlotte KY , Lim Raymond S , Selenica Pier , Li Anqi , Pareja Fresia , Fusco Nicola , Edelweiss Marcia , Kumar Rahul , Gularte‐Merida Rodrigo , Forbes Andre N , Khurana Ekta , Mariani Odette , Badve Sunil , Vincent‐Salomon Anne , Norton Larry , Reis‐Filho Jorge S , Weigelt Britta 
Published: November 2017

AbstractBreast adenoid cystic carcinoma (AdCC), a rare type of triple‐negative breast cancer, has been shown to be driven by MYB pathway activation, most often underpinned by the MYB–NFIB fusion gene. Alternative genetic mechanisms, such as MYBL1 rearrangements, have been reported in MYB–NFIB‐negative salivary gland AdCCs. Here we report on the molecular characterization by massively parallel sequencing of four breast AdCCs lacking the MYB–NFIB fusion gene. In two cases, we identified MYBL1 rearrangements (MYBL1–ACTN1 and MYBL1–NFIB), which were associated with MYBL1 overexpression. A third AdCC harboured a high‐level MYB amplification, which resulted in MYB overexpression at the mRNA and protein levels. RNA‐sequencing and whole‐genome sequencing revealed no definite alternative driver in the fourth AdCC studied, despite high levels of MYB expression and the activation of pathways similar to those activated in MYB–NFIB‐positive AdCCs. In this case, a deletion encompassing the last intron and part of exon 15 of MYB, including the binding site of ERG‐1, a transcription factor that may downregulate MYB, and the exon 15 splice site, was detected. In conclusion, we demonstrate that MYBL1 rearrangements and MYB amplification probably constitute alternative genetic drivers of breast AdCCs, functioning through MYBL1 or MYB overexpression. These observations emphasize that breast AdCCs probably constitute a convergent phenotype, whereby activation of MYB and MYBL1 and their downstream targets can be driven by the MYB–NFIB fusion gene, MYBL1 rearrangements, MYB amplification, or other yet to be identified mechanisms. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The safety of live attenuated influenza vaccine in children and adolescents 2 through 17 years of age: A Vaccine Safety Datalink study
Authors: Daley Matthew F. , Clarke Christina L. , Glanz Jason M. , Xu Stanley , Hambidge Simon J. , Donahue James G. , Nordin James D. , Klein Nicola P. , Jacobsen Steven J. , Naleway Allison L. , Jackson Michael L. , Lee Grace , Duffy Jonathan , Weintraub Eric 
Published: November 2017

AbstractPurposeTo evaluate the safety of live attenuated influenza vaccine (LAIV) in children 2 through 17 years of age.MethodsThe study was conducted in 6 large integrated health care organizations participating in the Vaccine Safety Datalink (VSD). Trivalent LAIV safety was assessed in children who received LAIV between September 1, 2003 and March 31, 2013. Eighteen pre‐specified adverse event groups were studied, including allergic, autoimmune, neurologic, respiratory, and infectious conditions. Incident rate ratios (IRRs) were calculated for each adverse event, using self‐controlled case series analyses. For adverse events with a statistically significant increase in risk, or an IRR > 2.0 regardless of statistical significance, manual medical record review was performed to confirm case status.ResultsDuring the study period, 396 173 children received 590 018 doses of LAIV. For 13 adverse event groups, there was no significant increased risk of adverse events following LAIV. Five adverse event groups (anaphylaxis, syncope, Stevens‐Johnson syndrome, adverse effect of drug, and respiratory failure) met criteria for manual medical record review. After review to confirm cases, 2 adverse event groups remained significantly associated with LAIV: anaphylaxis and syncope. One confirmed case of anaphylaxis was observed following LAIV, a rate of 1.7 per million LAIV doses. Five confirmed cases of syncope were observed, a rate of 8.5 per million doses.ConclusionsIn a study of trivalent LAIV safety in a large cohort of children, few serious adverse events were detected. Anaphylaxis and syncope occurred following LAIV, although rarely. These data provide reassurance regarding continued LAIV use.
Personality traits such as neuroticism and disability predict psychological distress in medically unexplained symptoms: A three‐year experience from a single centre
Authors: Menon Vikas , Shanmuganathan Balasubramanian , Thamizh Jaiganesh Selvapandian , Arun Anand Babu , Kuppili Pooja Patnaik , Sarkar Siddharth 
Published: November 2017

AbstractBackgroundPeople with medically unexplained symptoms (MUS) may have psychological co‐morbidities.AimsOur objectives were to assess the rates and identify correlates of psychological distress in MUS.MethodsA total of 171 subjects with MUS seeking treatment at a tertiary care facility were assessed over a 3‐year period. Psychological distress was assessed using the Tamil version of General Health Questionnaire‐12. Apart from socio‐demographic factors, personality, coping, perceived social support and subjective disability were assessed using standard instruments.ResultsNinety subjects (52.6%) endorsed symptoms of psychological distress. MUS subjects with psychological distress reported higher levels of neuroticism (p < 0.001), lower extraversion (p < 0.001), lower perceived social support (p = 0.002), higher disability (p < 0.001), lower problem focused engagement (p = 0.378) and higher emotion focused engagement (p = 0.009). In multivariate analysis, high neuroticism scores (odds ratio 1.579, 95% CI 1.108 to 2.251) and high disability (odds ratio 1.302, 95% CI 1.147 to 1.478) emerged as independent predictors of psychological distress in MUS.ConclusionMore than half of subjects with MUS have associated psychological distress. High levels of neuroticism and disability are potential markers of psychological distress in MUS. Copyright © 2017 John Wiley & Sons, Ltd.
Dithienosilole–phenylquinoxaline‐based copolymers with A‐D‐A‐D and A‐D structures for polymer solar cells
Authors: Keshtov Mukhamed L. , Khokhlov Alexei R. , Kuklin Sergei A. , Nikolaev Alexander Yu , Koukaras Emmanuel N. , Sharma Ganesh D. 
Published: November 2017

ABSTRACTTwo copolymers having D‐A‐D‐A (P1) and D‐A (P2) structures with quinoxaline acceptor unit and dithienosilole donor unit were synthesized and their optical and electrochemical (both experimental and theoretical) properties were investigated. The optical properties showed that these copolymers P1 and P2 exhibit optical bandgaps of 1.54 and 1.62 eV, respectively, with broader absorption profiles extending up to 800 nm and 770 nm, respectively. The electrochemical investigation of these two copolymers indicates that they exhibit suitable highest occupied molecular orbital and lowest unoccupied molecular orbital energy levels for efficient exciton dissociation and high open circuit voltage in the resultant polymer solar cells (PSCs). These copolymers were used as donors along with the PC71BM as acceptor for the fabrication of solution processed bulk heterojunction PSCs. The optimized P1:PC71BM and P2:PC71BM active layers treated with solvent vapor treatment showed overall power conversion efficiency (PCE) of 7.16% and 6.57%, respectively. The higher PCE of P1‐based device as compared to P2 might be attributed to higher crystallinity of P1 and good hole mobility resulting more balanced charge transport. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 376–386
Extension rate of the straight jet in electrospinning of poly(N‐isopropyl acrylamide) solutions in dimethylformamide: Influences of flow rate and applied voltage
Authors: Wang Yu , Hashimoto Takeji , Li Chang‐Chou , Li Yang‐Cheng , Wang Chi 
Published: November 2017

ABSTRACTIn the electrospinning process, the measurement of extension rate of the straight jet is not an easy task. In this study, the diameter profile of the tapering straight jet is determined with a laser light‐scattering technique. Afterwards, the jet extension rate () is derived and used to compare with the solution‐intrinsic rates, for example, the terminal relaxation rate and the Rouse relaxation rate. The extension rate of the straight jet depends on position: it is highest near the cone apex (region I) and decays to a constant value in the major jet (region II) until approaching the jet end (region III), at which the extension rate abruptly drops to nearly zero, that is,I>II≫III∼ 0. The jet diameter in region III is independent of solution concentration and applied voltage, but is scaled to the flow rate with an exponent of ∼0.37. The derived exponent is consistent with a simple prediction based on the counterbalance between the stretching electric force and the compressive force induced by the air drag force. Provided that air friction becomes overwhelming at the straight jet end, the long electrified jet is likely to buckle, thereby triggering the instability of jet whipping. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys.2018,56, 319–329
Differential Proteomic Analysis Reveals Protein Networks and Pathways that May Contribute to Helicobacter pylori FKBP‐Type PPIase‐Associated Gastric Diseases
Authors: Zhu Yanmei , Gong Yuehua , Li Aodi , Chen Moye , Kang Dan , Liu Jun , Yuan Yuan 
Published: November 2017

PurposeThough Helicobacter pylori (H. pylori) has been classified as class I carcinogen, key virulence factor generated by H. pylori that causes gastric cancer remains to be fully determined. Recently, we identified a gastric cancer‐associated H. pylori gene, peptidylprolyl isomerase‐FK506 binding protein (PPIase‐FKBP), and showed that PPIase‐FKBP was capable of inducing oncogenic transformation of gastric epithelial cells. But its mechanism was unclear.Experimental designWe carried out a comparative proteomic analysis of human gastric epithelial cells that either express PPIase‐FKBP or green fluorescent protein using 2‐DE and then MALDI‐TOF‐MS/MS.ResultsOur results identified 28 differentially expressed proteins induced by PPIase‐FKBP. These proteins participate in some cellular biological processes, such as cell proliferation, cell apoptosis and DNA replication, mRNA splicing, and protein biosynthesis. Ingenuity Pathway Analysis categorized the 28 proteins into two molecular interaction networks, involved primarily in cancer and gastrointestinal diseases.Conclusions and clinical relevanceOur results provided insight on the protein interaction networks and signaling pathways that may contribute to PPIase‐FKBP‐associated gastric diseases and may lead to a better understanding of the mechanisms indicating the oncogenic effects of H. pylori PPIase‐FKBP.
Dinitroaniline herbicide resistance in a multiple‐resistant Lolium rigidum population
Authors: Chen Jinyi , Yu Qin , Owen Mechelle , Han Heping , Powles Stephen 
Published: November 2017

AbstractBACKGROUNDThe pre‐emergence dinitroaniline herbicides (such as trifluralin and pendimethalin) are vital to Australian no‐till farming systems. A Lolium rigidum population collected from the Western Australian grain belt with a 12‐year trifluralin use history was characterised for resistance to dinitroaniline, acetyl CoA carboxylase (ACCase)‐ and acetolactate synthase (ALS)‐inhibiting herbicides. Target‐site resistance mechanisms were investigated.RESULTSThis L. rigidum population exhibited 32‐fold resistance to trifluralin, as compared with the susceptible population. It also displayed 12‐ to 30‐fold cross‐resistance to other dinitroaniline herbicides (pendimethalin, ethalfluralin and oryzalin). In addition, this population showed multiple resistance to commonly used post‐emergence ACCase‐ and ALS‐inhibiting herbicides. Two target‐site α‐tubulin gene mutations (Val‐202‐Phe and Thr‐239‐Ile) previously documented in other dinitroaniline‐resistant weed species were identified, and some known target‐site mutations in ACCase (Ile‐1781‐Leu, Asp‐2078‐Gly and Cys‐2088‐Arg) and ALS (Pro‐197‐Gln/Ser) were found in the same population. An agar‐based Petri dish screening method was established for the rapid diagnosis of resistance to dinitroaniline herbicides.CONCLUSIONEvolution of target‐site resistance to both pre‐ and post‐emergence herbicides was confirmed in a single L. rigidum population. The α‐tubulin mutations Val‐202‐Phe and Thr‐239‐Ile, documented here for the first time in L. rigidum, are likely to be responsible for dinitroaniline resistance in this population. Early detection of dinitroaniline herbicide resistance and integrated weed management strategies are needed to maintain the effectiveness of dinitroaniline herbicides. © 2017 Society of Chemical Industry
Monitoring resistance of Cydia pomonella (L.) Spanish field populations to new chemical insecticides and the mechanisms involved
Authors: Bosch Dolors , Rodríguez Marcela A , Avilla Jesús 
Published: November 2017

AbstractBACKGROUNDWidespread resistance of Cydia pomonella to organophosphates was demonstrated in populations from the Spanish Ebro Valley area which showed high levels of enzymatic detoxification. To determine the efficacy of new insecticides, neonate larval bioassays were carried out on 20 field codling moth populations collected from three different Spanish apple production areas. Synergist bioassays were performed to determine the enzymatic mechanisms involved.RESULTSThe least active ingredients were methoxyfenozide, with 100% of the populations showing significantly lower mortality than the susceptible strain, and lambda‐cyhalothrin, with very high resistance ratios (872.0 for the most resistant field population). Approximately 50% of the populations were resistant or tolerant to thiacloprid. By contrast, tebufenozide was very effective in all the field populations, as was chlorpyrifos‐ethyl despite its widespread use during the last few years. Indoxacarb, spinosad and chlorantraniliprole also provided high efficacy, as did emamectin and spinetoram, which are not yet registered in Spain.CONCLUSIONThe resistant Spanish codling moth populations can be controlled using new reduced‐risk insecticides. The use of synergists showed the importance of the concentration applied and the difficulty of interpreting results in field populations that show multiple resistance to different active ingredients. © 2017 Society of Chemical Industry
Ambrosia artemisiifolia as a potential resource for management of golden apple snails, Pomacea canaliculata (Lamarck)
Authors: Ding Wenbing , Huang Rui , Zhou Zhongshi , He Hualiang , Li Youzhi 
Published: November 2017

AbstractBACKGROUNDAmbrosia artemisiifolia, an invasive weed in Europe and Asia, is highly toxic to the golden apple snail (GAS; Pomacea canaliculata) in laboratory tests. However, little is known about the chemical components of A. artemisiifolia associated with the molluscicidal activity or about its potential application for GAS control in rice fields. This study evaluated the molluscicidal activities of powders, methanol extracts, and individual compounds from A. artemisiifolia against GAS in rice fields and under laboratory conditions.RESULTSAmbrosia artemisiifolia powders did not negatively affect the growth and development of rice but they reduced damage to rice caused by GAS. Extracts had moderate acute toxicity but potent chronic toxicity. The 24‐h 50% lethal concentration (LC50) of the extracts against GAS was 194.0 mg L–1, while the weights, lengths and widths of GAS were significantly affected by exposure to a sublethal concentration (100 mg/mL). Psilostachyin, psilostachyin B, and axillaxin were identified as the most active molluscicide components in the aerial parts of A. artemisiifolia, and the 24‐h LC50 values of these purified compounds were 15.9, 27.0, and 97.0 mg/L, respectively.CONCLUSIONThe results indicate that chemical compounds produced by A. artemisiifolia may be useful for population management of GAS in rice fields. © 2017 Society of Chemical Industry