bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cortical Alterations in Medication‐Overuse Headache
Authors: Riederer Franz , Schaer Marie , Gantenbein Andreas R. , Luechinger Roger , Michels Lars , Kaya Marihan , Kollias Spyridon , Sándor Peter S. 
Published: December 2016

ObjectiveUsing surface‐based morphometry we aimed to provide a detailed examination of cortical alterations in medication‐overuse headache (MOH), by disentangling between altered cortical thickness and gyrification (folding).BackgroundIn MOH, pain modulation is probably dysfunctional at the cortical and subcortical level, resulting in a disequilibrium between pain inhibition and facilitation. Both increased and decreased cortical volumes have been reported in individuals with MOH. There is however no detailed examination to date that distinguishes between altered cortical thickness and gyrification. Such distinction would help to identify the nature and timing of neurodevelopmental mechanisms at play in affected individuals.MethodsWe investigated cortical thickness and gyrification in 29 patients with MOH according to International Headache Society criteria and 29 age‐ and gender‐matched controls, using high‐resolution structural MRIs of the brain analyzed with FreeSurfer. This is a secondary analysis of data from a previously published voxel‐based morphometry study.ResultsIn patients with MOH compared to controls, reduced cortical thickness was observed in the left prefrontal cortex. We also observed higher local gyrification in one cluster extending from the fusiform cortex to adjacent medial temporal regions, and in another cluster in the right occipital pole. Higher gyrification in the right occipital pole predicted poor response after detoxification.ConclusionsCorroborating previous volumetric results, our study adds information on the putative neurobiological mechanisms involved in MOH, suggesting neurodevelopmental changes in MOH.
Structural Gray Matter Alterations in Chronic Migraine: Implications for a Progressive Disease?
Authors: Neeb Lars , Bastian Kaili , Villringer Kersten , Israel Heike , Reuter Uwe , Fiebach Jochen B. 
Published: December 2016

ObjectiveTo identify possible gray matter alterations in patients with chronic migraine using voxel‐based morphometry (VBM).BackgroundVBM studies demonstrate structural alterations of gray matter (GM) in episodic migraine (EM) patients. Some of these alterations correlate with disease duration and headache frequency. We assessed GM alterations in chronic migraine (CM) and EM to evaluate the concept of migraine as a progressive disorder of the brain.MethodsIndividually age and sex‐matched subjects with CM or EM (both without aura) and healthy controls (n = 21 per group) underwent magnetic resonance imaging‐based VBM.ResultsWe found an increase of GM volume (GMV) in amygdala and putamen, in CM compared to controls. GMV of EM compared to controls did not differ statistically significantly. Headache frequency in all migraineurs (EM and CM) correlated positively with GMV in putamen, frontal and temporal gyrus and negatively in left cuneus.ConclusionCM is associated with structural changes in brain regions involved in pain processing but also in affective and cognitive aspects of pain. Some GM alterations are correlated with headache frequency assessed in EM and CM. The findings support the assumption that chronic pain alters brain plasticity. GMV increase may reflect a remodeling of the central nervous system due to repetitive headache attacks leading to chronic sensitization and a continuous ictal‐like state of the brain in chronic migraineurs.
Sexual Dysfunction in Women With Migraine and Overweight/Obesity: Relative Frequency and Association With Migraine Severity
Authors: Bond Dale S. , Pavlović Jelena M. , Lipton Richard B. , Graham Thomas J. , Digre Kathleen B. , Roth Julie , Rathier Lucille , O'Leary Kevin C. , Evans E. Whitney , Wing Rena R. 
Published: December 2016

Background/ObjectivePrevious studies suggest that migraine might be associated with female sexual dysfunction (FSD), although this association may be complicated by overweight/obesity. To disentangle relationships of migraine and obesity with FSD, we examined: (1) FSD rates in women who had migraine and obesity with a matched sample of women with obesity who were free of migraine and (2) associations between indices of migraine severity and FSD in a larger sample of participants with migraine and overweight/obesity, controlling for important confounders.MethodsWomen with migraine and obesity seeking behavioral weight loss treatment to decrease headaches (n = 37) and nonmigraine controls (n = 37) with obesity seeking weight loss via bariatric surgery were matched on age (±5 years), body mass index (BMI; ±3 kg/m2), and reported sexual activity during the past month. Both groups completed the Female Sexual Function Index (FSFI), with a validated FSFI‐total cutoff score used to define FSD. In participants with migraine and overweight/obesity (n = 105), separate logistic regression models evaluated associations of migraine attack frequency, intensity, and duration with odds of having FSD, controlling for age, BMI, depression, and anxiety.ResultsOn average, participants and matched controls had severe obesity (BMI = 42.4 ± 3.8 kg/m2; range = 35‐49.9) and were 37.3 ± 7.2 years of age (range = 22‐50). FSD rate did not differ between migraine participants and controls (56.8% vs. 54.1%, P = .82). In the larger sample of participants with migraine and overweight/obesity (38.2 ± 7.8 years of age; BMI = 34.8 ± 6.4 [range = 25‐50 kg/m2]; 8.0 ± 4.3 migraine days/month, maximum pain intensity = 5.9 ± 1.4 on 0‐10 scale; average attack duration = 18.3 ± 9.7 hours), FSD was not associated with attack frequency (P = .31), pain intensity (P = .92), or attack duration (P = .35) but was associated with more severe anxiety symptoms (Ps < .017).ConclusionsRates of sexual dysfunction did not differ in severely obese women with and without migraine. Moreover, indices of migraine severity were not associated with increased risk of FSD in women with overweight/obesity. Replication of present findings in wider populations of women with migraine and of both normal‐weight and overweight/obese status are warranted.
A novel isolation protocol and probe‐based RT‐PCR for diagnosis of gastric infections with the zoonotic pathogen Helicobacter suis
Authors: Blaecher Caroline , Bauwens Eva , Tay Alfred , Peters Fanny , Dobbs Sylvia , Dobbs John , Charlett André , Ducatelle Richard , Haesebrouck Freddy , Smet Annemieke 
Published: December 2016

AbstractBackgroundHelicobacter suis is a very fastidious microorganism associated with gastritis, gastric ulcers, and mucosa‐associated lymphoid tissue lymphoma in humans. In vitro isolation of this agent from human patients has so far been unsuccessful.Materials and methodsA probe‐based real‐time PCR (RT‐PCR) for the rapid detection of H. suis in gastric biopsies was developed. Secondly, a mouse‐passage‐based protocol was optimized for isolation of low numbers of viable H. suis bacteria. Mice were inoculated with different numbers of viable H. suis (102‐108) and kept for 4 weeks to allow multiplication of this pathogen.ResultsThe probe‐based real‐time PCR (RT‐PCR) exhibited a high degree of diagnostic specificity and analytical sensitivity, high linear correlations (r2 between 0.995 and 0.999), and high amplification efficiencies (>90%) for H. suis. No cross‐reactivity was detected with human, porcine, non‐human primate, and murine DNA nor with DNA from other bacteria including Helicobacter spp. and Campylobacter spp. H. suis was successfully re‐isolated from the stomach of mice inoculated with at least 104 viable H. suis, using a biphasic medium (pH 5), consisting of Brucella agar with Brucella broth on top, both supplemented with vitox supplement, Campylobacter‐selective supplement, amphotericin (5 μg/mL), HCl (0.05%), fetal bovine serum (20%), and linezolid (5 μg/mL). Linezolid was necessary to inhibit proliferation of contaminants, including lactobacilli.ConclusionThe methods described above can be implemented for detection or isolation of H. suis from human gastric biopsies.
Prognostic stratification of oestrogen receptor‐positive HER2‐negative lymph node‐negative class of breast cancer
Authors: Rakha Emad A , Agarwal Devika , Green Andrew R , Ashankyty Ibraheem , Ellis Ian O , Ball Graham , Alaskandarany Mohammed A 
Published: December 2016

AimsMultigene assay is recommended currently for prognostic stratification of the clinically indeterminate group of breast cancer (BC) patients defined as lymph node (LN)‐negative, oestrogen receptor (ER)‐positive, HER2‐negative (LN−/ER+/HER2−) to determine the use of chemotherapy. However, this cohort, comprising approximately 40% of BC, is not a homogeneous group and shows variable outcome. This study aims to determine the prognostic value of routinely assessed variables, singly and in combination, in LN−/ER+/HER2− BC patients.Methods and resultsA total of 830 LN−/ER+/HER2− chemotherapy‐naive BCs were investigated. The prognostic value of histological grade, tumour size, lymphovascular invasion (LVI), progesterone receptor (PgR) and Ki67 labelling index (Ki67LI) was assessed. In this series, only 25% of patients received hormone therapy. Median follow‐up was 172 months. In the whole cohort, tumour grade, size, LVI, PgR and Ki67LI were correlated highly with outcome in a time‐dependent manner. The outcome of this group varied widely from 97% (20% of cases) to 50% survival rate after 10‐year follow‐up using a combination of these markers. A prognostic index (Nottingham Px) incorporating grade, size, PgR and Ki67LI, was developed. The index can stratify the whole cohort robustly as well as the higher‐risk subgroup (NPI score >3.4) into distinct prognostic classes.ConclusionCurrent routinely assessed variables can provide additional prognostic information in LN−/ER+/HER2− BC. The proposed (Nottingham Px) index can stratify the BC clinically indeterminate group of patients into excellent and poor prognostic subgroups and can be used to identify reliably patients for systemic chemotherapy or further multigene prognostic testing. Performance of prognostic variables in these tumours is time‐dependent, and should be considered in future studies.
Marital relationship and health‐related quality of life after prostate cancer diagnosis
Authors: Harju Eeva , Rantanen Anja , Kaunonen Marja , Helminen Mika , Isotalo Taina , Åstedt‐Kurki Päivi 
Published: December 2016

ABSTRACTProstate cancer has an impact on the health‐related quality of life (HRQoL) of patients and their spouses. However, the marital relationship at the time of prostate cancer diagnosis is not well known. The aim of the study was to describe and compare the marital relationship of patients with prostate cancer and their spouses and to identify factors associated with HRQoL at the time of diagnosis. The data of this cross‐sectional study were collected with The Marital Questionnaire and RAND‐36 Item Health Survey scales after the diagnosis of prostate cancer from 232 patients and 229 spouses at five Finnish central hospitals from October 2013 to January 2016. Patients with prostate cancer rated their dyadic satisfaction better than their spouses. Respectively, spouses reported better dyadic cohesion. The marital relationship of the patients or spouses was not associated with demographic variables of the respondents. In patients, energy, emotional well‐being and general health were associated with the marital relationship. In spouses, emotional role functioning, emotional well‐being and social functioning were explained by the marital relationship. At the time of diagnosis, the marital relationship of patients with prostate cancer and their spouses was good. However, there were differences in associations between patients' and their spouses' marital relationship and HRQoL. Based on the results of this study, it is useful to take into account the spouses and the marital relationship in the nursing of patients with prostate cancer. The follow‐up research on this subject is needed.
Specification Error, Estimation Risk, and Conditional Portfolio Rules
Authors: Carlson Murray , Chapman David A. , Kaniel Ron , Yan Hong 
Published: December 2016

AbstractIn characterizing the data‐generating process for excess returns, an investor faces both parameter uncertainty (or “estimation risk”) and specification error. We examine the trade‐off between these two effects, in the context of an optimal consumption/portfolio decision problem, by considering a minimal extension of the standard assumption of a linear vector autoregression for excess returns. The key additional assumption in our data‐generating process is a positive linear relationship between market volatility and lagged market dividend yields. This simple specification is consistent with a long sample of U.S. data. We show that volatility adjusted rules are substantially less sensitive to variation in dividend yields, and volatility‐related specification error is economically significant – even when the decisions are based on sample estimates from data sets of a realistic size.
Facilitators' delivery of a psychosocial intervention in a controlled trial for men with prostate cancer and their partners: a process evaluation
Authors: Parahoo Kader , McKenna Suzanne , Prue Gillian , McSorley Oonagh , McCaughan Eilis 
Published: December 2016

AbstractAimThe aim of this paper was to report the process evaluation of facilitators' delivery of a psychosocial intervention (called CONNECT), in a randomized controlled trial, to men with prostate cancer and their partners.BackgroundThere is a lack of information on the process of implementing psychosocial interventions in controlled trials and, in particular, on the role and performance of facilitators who deliver them. Yet, this information is crucial in assessing whether these interventions are effective or not and why.DesignQualitative design.MethodsSemi‐structured qualitative interviews and diaries were used to collect data (January–October 2012) from four facilitators and a co‐facilitator. Data were analysed using the Miles et al. framework.ResultsFive themes were discernible. These were ‘difficulties to keep to the structure of the intervention’, ‘selective coverage of topics’, ‘partner participation’, ‘overall impression of the group and telephone sessions’ and ‘perceived benefits to participants’. Issues such as not keeping to the aim of the intervention, deviating from the content and/or reluctance in discussing sensitive issues such as sexual health may mean that the psychosocial effects of the intervention may not have been fully realized.ConclusionsThese findings will be useful for further development and evaluation of the intervention. A tentative conceptual framework of factors, related to facilitators, influencing the fidelity of interventions in the context of controlled trials, is offered. This model, which requires further development and testing, will be useful for researchers worldwide who are involved in developing interventions and training facilitators.
Neutral and selective drivers of colour evolution in a widespread Australian passerine
Authors: Morales Hernán E. , Pavlova Alexandra , Sunnucks Paul , Major Richard , Amos Nevil , Joseph Leo , Wang Biao , Lemmon Alan R. , Endler John A. , Delhey Kaspar 
Published: December 2016

AbstractAimRump plumage coloration of the Eastern Yellow Robin (Eopsaltria australis), a widespread Australian songbird, varies from bright yellow in the tropical north to olive‐green in the temperate south. Here, we test whether colour variation: (1) correlates most strongly with neutral genetic variation and so is best explained by historical processes, (2) reflects selection associated with different visual environments (dense versus open habitats) and/or (3) reflects selection associated with climatic variation.LocationEastern Australia.MethodsWe quantified colour variation using reflectance spectrometry and visual models. We performed geographical cline analysis of colour and neutral genetic variation (genome‐wide single nucleotide polymorphisms). We tested for correlations of colour variation with climate, vegetation density, geographical location and genetic variation. We accounted for covariation and spatial autocorrelation, and conducted analyses at continental and regional spatial scales.ResultsClinal variation of colour traits and neutral genetic markers were largely concordant. At the continental scale, colour variation was strongly associated with neutral genetic structure and geography, and to a lesser extent with environment. At the regional scale, environmental variation was a better predictor of colour variation than it was at the larger scale.Main conclusionAt the continental scale, colour variation is strongly associated with large‐scale population history. In contrast, at the regional scale, where the influence of history and geography is weaker, environmental variation has a role in facilitating the maintenance of colour variation. Our results highlight the need to assess selective and neutral alternatives at multiple spatial scales when studying geographical variation.
Applying augmented reality to enhance learning: a study of different teaching materials
Authors: Hung Y.‐H. , Chen C.‐H. , Huang S.‐W. 
Published: December 2016

AbstractThe objective of this study was to determine the usefulness of augmented reality (AR) in teaching. An experiment was conducted to examine children's learning performances, which included the number of errors they made, their ability to remember the content of what they had read and their satisfaction with the three types of teaching materials, including a picture book, physical interactions and an AR graphic book. The three teaching materials were aimed to respectively demonstrate the characteristics of six bacteria with 2D graphics, 3D physical objects, and 3D virtual objects. Seventy‐two fifth‐grade children were randomly selected to participate in the study, and they were divided into three groups, each of which used the assigned teaching material to learn the name of the six different bacteria in intervals of 1, 2 and 3 min. Results showed that the AR graphic book offers a practical and hands‐on way for children to explore and learn about the bacteria. Follow‐up interviews indicated that the children liked the AR graphic book the most, and they preferred it to the other materials.Lay DescriptionWhat is currently known about Augmented Reality and learning?

Augmented reality (AR) provides a new perspective for learning by allowing learners to visualize complex spatial relationships and abstract concepts.
What the paper adds to the subject matter?

AR improves learning performances to a similar extent as the most used teaching materials (both picture books and physical interactions) do.
AR not only facilitates learning but also increases learning motivations better than conventional teaching materials do.The implications of study findings for practitioners.

If children feel bored about reading textbooks, give them AR (because AR effectively enhances learning and children are more motivated when using AR).
AR teaching material is a good alternative to conventional picture book and physical interactions.
Long‐term tooth retention in chronic periodontitis – results after 18 years of a conservative periodontal treatment regimen in a university setting
Authors: Graetz Christian , Plaumann Anna , Schlattmann Peter , Kahl Maren , Springer Claudia , Sälzer Sonja , Gomer Konstantin , Dörfer Christof , Schwendicke Falk 
Published: December 2016

AbstractAimThe longitudinal study assessed the risk of tooth loss under a non‐regenerative treatment regimen and aimed to identify prognostic factors for tooth loss.MethodsThree hundred and fifteen patients (8009 teeth) were examined before (T0) and after active periodontal therapy (APT, T1) as well as after (mean ± SD) 18 ± 6 years of supportive periodontal therapy (SPT, T2). Descriptive statistics and a Cox proportional hazards shared‐frailty model were applied.ResultsOverall, 351 and 816 teeth were lost during APT and SPT, respectively, with 0.15 ± 0.17 teeth being lost per patient and year. Seventy‐two percentage patients lost 0–3, 24% 4–9 and 4% ≥10 teeth. The proportion of teeth with probing‐pocket depths (PPD) >6 mm was 17.2% (T0), 1.6% (T1) and remained stable at 1.7% up to T2. Tooth loss during SPT was significantly increased in older patients [HR (95% CI): 1.04 (1.01–1.07) per year] and smokers [2.62 (1.34–5.14)], with each mm of PPD [1.35 (1.17–1.56)], in multirooted compared with single‐rooted teeth [1.86 (1.36–2.56)] and teeth with bone loss [BL; HR up to 23.6 (12.1–45.6) for BL > 70%].ConclusionThe risk of tooth loss was generally low under the provided non‐regenerative treatment regimen; a minority of patients were responsible for the majority of teeth lost during SPT.
The association between undiagnosed glycaemic abnormalities and cardiometabolic risk factors with periodontitis: results from 2007–2009 Canadian Health Measures Survey
Authors: Zuk Aleksandra , Quiñonez Carlos , Lebenbaum Michael , Rosella Laura C. 
Published: December 2016

AbstractAimThe aim was to investigate the association between undiagnosed glycaemic abnormalities and cardiometabolic risk factors with periodontitis.MethodsUsing Cycle 1 (2007–2009) of Canadian Health Measures Survey, survey‐sampling weights were applied to a restricted sample of fasting, non‐pregnant adults between 19 and 79 years of age without diagnosed or treated type 2 diabetes. We estimated the prevalence of periodontitis and various cardiometabolic risk factors according to the clinical diagnostic definition for metabolic syndrome (MetS), recognized by the American Heart Association and National Heart, Lung, and Blood Institute. Adjusted logistic regression models were used to estimate prevalence odds ratios (PORs) examining the association between cardiometabolic risk factors and periodontitis among dentate adults with available attachment loss measures.ResultsThe prevalence of combined moderate‐to‐severe periodontitis was 17.93% (95% CI 15.85, 20.02). Hyperglycaemia (fasting plasma glucose (FPG) ≥ 5.6 mmol/l) was significantly associated with periodontitis, POR = 1.60 (95% (CI) 1.04, 2.45), but was no longer significant after controlling for socioeconomic status variables. Central adiposity, dyslipidaemia and hypertension were not associated with periodontitis.ConclusionGlucose disruption measured by FPG was associated with periodontitis; however, no association was observed with other cardiometabolic risk factors or MetS in a cross‐sectional, nationally representative sample of Canadian adults.
The complex interplay between macronutrient intake, cuticular hydrocarbon expression and mating success in male decorated crickets
Authors: Rapkin J. , Jensen K. , House C. M. , Sakaluk S. K. , Sakaluk J. K. , Hunt J. 
Published: December 2016

AbstractThe condition dependence of male sexual traits plays a central role in sexual selection theory. Relatively little, however, is known about the condition dependence of chemical signals used in mate choice and their subsequent effects on male mating success. Furthermore, few studies have isolated the specific nutrients responsible for condition‐dependent variation in male sexual traits. Here, we used nutritional geometry to determine the effect of protein (P) and carbohydrate (C) intake on male cuticular hydrocarbon (CHC) expression and mating success in male decorated crickets (Gryllodes sigillatus). We show that both traits are maximized at a moderate‐to‐high intake of nutrients in a P:C ratio of 1 : 1.5. We also show that female precopulatory mate choice exerts a complex pattern of linear and quadratic sexual selection on this condition‐dependent variation in male CHC expression. Structural equation modelling revealed that although the effect of nutrient intake on mating success is mediated through condition‐dependent CHC expression, it is not exclusively so, suggesting that other traits must also play an important role. Collectively, our results suggest that the complex interplay between nutrient intake, CHC expression and mating success plays an important role in the operation of sexual selection in G. sigillatus.