bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges experienced by health care providers working in both hospital and home-based palliative care units in Dhaka city: A multi-center based cross-sectional study
Authors: Kashmeeri Mastura , Islam A. N. M. Shamsul , Banik Palash Chandra 
Published: September 2024

Background
Palliative care is paramount in the modern clinical field worldwide. However, in Bangladesh, its acceptance is limited compared to other related sectors, despite the country suffering from a huge burden of life-limiting diseases. Besides, PC teams and their approach to care are entirely different from the conventional clinical approach. This study aimed to explore the challenges faced by healthcare providers working in the palliative care unit in Bangladesh, including all groups.

Design
This was a cross-sectional descriptive survey involving palliative care providers.

Methods
A self-administered pre-tested questionnaire was used for data collection. Data was analyzed using descriptive statistics and Chi-square at p <0.05.

Result
The mean age of the respondents was 33.59 ± 8.05 years, and barely most (82.5%) had served for 7–9 years. More than half (51%) of doctors and 31% of nurses claimed patient agitation as a challenge. Almost all groups of respondents exhibit ethical dilemma as a barrier, although a significant relationship was found between professional level and ethical dilemma. More than half of doctors (51%), 41.5% of nurses, and 29.5% of PCA-ward staff mentioned the lack of telemedicine facilities as a challenge. Nearly half (47.1%) of doctors and nurses claimed that patients’ families had made patient care difficult, on the other hand, PCA-ward staff (70%) group ignorance of family did the same thing. Opioid phobia of other health professionals restricted the growth mentioned by the majority of all four groups of respondents. A significant relationship was found between limited dose formulation and experience of HPs (p<0.07). At the institutional level, 93.3% of nursing staff agreed that the lack of supporting staff was a drawback. A significant relationship was also found between the type of institution and the lack of a support system to conduct home-based care (p<0.002). Moreover, the majority (83.3%) of PCA-WS exhibit a lack of career development opportunities (p<0.001) as a barrier, besides, more than 7 out of 10 doctors (7.2%) felt social discrimination as a challenge(p<0.001).

Conclusion
Introducing new concepts comes with obstacles, but proper planning and awareness can make it necessary. Incorporating it into primary healthcare can create new job opportunities and increase familiarity among the general population. Training healthcare professionals on opioid handling can also increase its acceptance.
Synergistic celecoxib and dimethyl-celecoxib combinations block cervix cancer growth through multiple mechanisms
Authors: Robledo-Cadena Diana Xochiquetzal , Pacheco-Velázquez Silvia Cecilia , Vargas-Navarro Jorge Luis , Padilla-Flores Joaquín Alberto , López-Marure Rebeca , Pérez-Torres Israel , Kaambre Tuuli , Moreno-Sánchez Rafael , Rodríguez-Enríquez Sara 
Published: September 2024

Objective
The synergistic inhibitory effect of celecoxib (CXB) and dimethyl-celecoxib (DMC) plus paclitaxel (PA) or cisplatin (CP) on human cervix HeLa and SiHa cells was assessed at multiple cellular levels in order to elucidate the biochemical mechanisms triggered by the synergistic drug combinations.

Methods
The effect of CXB (5 μM)/CP (2 μM) or CXB (5 μM)/PA (15 μM) and DMC (15 μM)/CP (5 μM) or DMC (15 μM)/PA (20 μM) for 24 h was assayed on cancer cell proliferation, energy metabolism, mitophagy, ROS production, glycoprotein-P activity, DNA stability and apoptosis/necrosis.

Results
Drug combinations synergistically decreased HeLa and SiHa cell proliferation (>75%) and arrested cellular cycle by decreasing S and G2/M phases as well as the Ki67 content (HeLa) by 7.5–30 times. Cell viability was preserved (>90%) and no apparent effects on non-cancer cell growth were observed. Mitochondrial and glycolytic protein contents (44–95%) and ΔΨm (45–50%) in HeLa cells and oxidative phosphorylation and glycolysis fluxes (70–90%) in HeLa and SiHa cells were severely decreased, which in turn promoted a drastic fall in the ATP supply (85–88%). High levels of mitophagy proteins in HeLa cells and active mitochondrial digestion in HeLa and SiHa cells was observed. Mitochondrial fission and microtubule proteins were also affected. Intracellular ROS content (2–2.3-fold) and ROS production was stimulated (2.3–4 times), whereas content and activity of glycoprotein-P (45–85%) were diminished. DNA fragmentation was not observed and apoptosis/necrosis was not detected suggesting that cell death could be mainly associated to mitophagy induction.

Conclusions
CXB or DMC combination with canonical chemotherapy may be a promising chemotherapy strategy against cervical cancer growth, because it can selectively block multiple cell processes including inhibition of energy pathways and in consequence ATP-dependent processes such as cell proliferation, glycoprotein-P activity, ROS production and mitophagy, with no apparent effects on non-cancer cells.
Self-management education for hypertension, diabetes, and dyslipidemia as major risk factors for cardiovascular disease: Insights from stakeholders’ experiences and expectations
Authors: Soleimani Nazanin , Ebrahimi Fatemeh , Mirzaei Masoud 
Published: September 2024

Background
Cardiovascular disease (CVD) is a leading cause of premature death, with hypertension, diabetes, and dyslipidemia as major risk factors. Effective self-management (SM) is crucial for controlling these conditions and improving quality of life. This study examines stakeholders’ experiences and expectations of SM education to enhance program development.

Methods
This study employed a qualitative grounded theory approach to explore the perspectives of three stakeholder groups: 19 patients with hypertension, type 2 diabetes, and dyslipidemia, 11 primary healthcare providers, and five provincial health policymakers and managers. Data were collected via semi-structured patient interviews and focus group discussions(FGDs) with health professionals. Coding and analysis were conducted separately using Corbin and Strauss principles with ATLAS. ti version 9.0 software.

Results
Most patients were women (68%) aged 50–60 years (37%), with education levels from illiterate to master’s degree; 32% had completed primary school. Most were housewives (52%), and 12 had multiple chronic diseases. Healthcare providers included six community health workers and five primary care physicians, with average experience of 12 and 19 years, respectively. Health policymakers and managers averaged 25 years of experience. Patient interviews and FGDs resulted in 12 and 13 subthemes, respectively, with five subthemes common to both sources. These subthemes were grouped into broader main themes, including "effective content design," "effective presentation and delivery," "characteristics and conditions of involved parties," and "educational needs," collectively reflect the central concept of "effective self-management education".

Conclusion
Although the core concept and its main themes were evident and consistent across stakeholder groups, significant variations in subthemes from each stakeholder emerged. This underscores the importance of considering diverse viewpoints and highlights that, while overarching concepts may seem uniform, exploring the details of stakeholder perspectives is crucial for understanding their nuanced opinions. Effective education should integrate these insights, focusing on tailored communication, interactivity, and active monitoring.
Intestinal Ultrasound: Envisioning a New Future for Crohn's Disease Management
Authors: Randhawa Amrik , Guzowski Tom 
Published: September 2024

ABSTRACT
The use of intestinal ultrasound (IUS) in the clinical assessment of intestinal disorders remains in its infancy in North America. We present a case in which IUS was used as a complement to Crohn's disease treatment in a 19-year-old man. After endoscopy and diagnosis, IUS was employed alongside other investigations to elucidate the extent of disease activity. It allowed identification and monitoring of complications such as free fluid and mucosal inflammation. IUS provided a marker of disease activity, even during apparent clinical remission. This case demonstrates that IUS can enhance disease monitoring and inform direction of therapy.
Potrebe staršev otrok z motnjo avtističnega spektra
Authors: Hodaj Tina , Ramšak Pajk Jožica 
Published: September 2024

Uvod: Avtistične motnje so skupina razvojnih motenj z največjim primanjkljajem na področju socialne komunikacije in interakcije. Namen pregleda literature je raziskati in predstaviti težave, s katerimi se soočajo starši otrok z avtistično motnjo.Metode: Uporabljen je bil pristop pregleda tuje in domače literature s pomočjo bibliografskih baz CINAHL, COBISS, PubMed, SpringerLink in brskalnika Google učenjak. Iskalni pojmi so bili: zgodnja obravnava, avtistična motnja, starši, stres, diagnoza oziroma early intervention, autism disorder, parents, stress in diagnosis. Iskalna strategija je temeljila na vključevalnih kriterijih: objava literature med letoma 2012 in 2022, dostopnost celotnega besedila in slovenski ali angleški jezik besedila.Rezultati: Glede na vključitvene kriterije smo pridobili 31.217 zadetkov, v končno analizo pa vključili 13 virov. Rezultati so pokazali štiri kategorije: negativna čustva in občutki, ki jih doživljajo starši otrok z avtistično motnjo; prepreke staršev otrok z avtistično motnjo; podpora staršem otrok z avtistično motnjo ter želje in potrebe staršev otrok z avtistično motnjo.Diskusija in zaključek: Starši otrok z avtistično motnjo se soočajo s številnimi negativnimi čustvi in občutki, kot so preobremenjenost, strah, tesnoba, izčrpanost, nerazumevanje, doživljanje preprek pri iskanju informacij in podpore. Zgodnje diagnosticiranje avtistične motnje pri otroku in s tem zgodnji pristop do potrebnih storitev lahko izboljšata rezultate pri otroku, zmanjšata finančne stroške in izboljšata obvladanje stresa pri starših.
(α, F)-Geraghty-type generalized F-contractions on non-Archimedean fuzzy metric-unlike spaces
Authors: Alam Khairul Habib , Rohen Yumnam , Tomar Anita 
Published: September 2024

Abstract
In this study, we generalize fuzzy metric-like, non-Archimedean fuzzy metric-like, and all the variants of fuzzy metric spaces. We propose the idea of fuzzy metric-unlike and non-Archimedean fuzzy metric-unlike, respectively. We also propose the idea of

(

α
,
F

)

\left(\alpha ,F)

-Geraghty-type generalized

F

F

-contraction mappings utilizing fuzzy metric-unlike and non-Archimedean fuzzy metric-unlike spaces. We investigate the presence of unique fixed points using the recently introduced contraction mappings. In order to complement our study, we consider an application to dynamic market equilibrium.
Three-dimensional composite substrate based on pyramidal pitted silicon array adhered Au@Ag nanospheres for high-performance surface-enhanced Raman scattering
Authors: Zhang Wei , Liu Siqi , Jiang Sijia , Zhang Jiahang , Ma Hongtao , Xu Liang , Yang Mingyu , Ma Ding , Jiao Qingbin , Tan Xin 
Published: September 2024

Abstract
As a noninvasive and label-free optical technique, Raman spectroscopy offers significant advantages in studying the structure and properties of biomacromolecules, as well as real-time changes in cellular molecular structure. However, its practical applications are hindered by weak scattering responses, low signal intensity, and poor spectral uniformity, which affect the subsequent accuracy of spectral analysis. To address these issues, we report a novel surface-enhanced Raman scattering (SERS) substrate based on a pyramidal pitted silicon (PPSi) array structure adhered with Au-shell Ag-core nanospheres (Au@Ag NSs). By preparing a highly uniform PPSi array substrate with controllable size and arrangement, and constructing SERS-active Au@Ag NSs on this substrate, a three-dimensional (3D) composite SERS substrate is realized. The enhancement performance and spectral uniformity of 3D composite SERS substrate were examined using crystal violet (CV) and Rhodamine 6G (R6G) molecules, achieving a minimum detectable concentration of R6G at 10−9 M and the analytical enhancement factor (AEF) of 4.2 × 108. Moreover, SERS detection of biological samples with varying concentrations of Staphylococcus aureus demonstrated excellent biocompatibility of the SERS substrate and enabled quantitative analysis of bacterial concentration (R
2 = 99.7 %). Theoretical simulations using finite-difference time-domain (FDTD) analysis were conducted to examine the electromagnetic field distribution of the three-dimensional SERS composite substrate, confirming its local electric field enhancement effect. These experimental and theoretical results indicate that the Au@Ag NSs/PPSi substrate with a regulable pyramidal pitted array is a promising candidate for sensitive, label-free SERS detection in medical and biotechnological applications.
Quantum efficiency of the B-center in hexagonal boron nitride
Authors: Yamamura Karin , Coste Nathan , Zeng Helen Zhi Jie , Toth Milos , Kianinia Mehran , Aharonovich Igor 
Published: September 2024

Abstract
B-centers in hexagonal boron nitride (hBN) are gaining significant research interest for quantum photonics applications due to precise emitter positioning and highly reproducible emission wavelengths at 436 nm. Here, we leverage the layered nature of hBN to directly measure the quantum efficiency (QE) of single B-centers. The defects were engineered in a 35 nm flake of hBN using electron beam irradiation, and the local dielectric environment was altered by transferring a 250 nm hBN flake on top of the one containing the emitters. By analyzing the resulting change in measured lifetimes, we determined the QE of B-centers in the thin flake of hBN. Additionally, we propose two approaches to quantify the QE of B-centers in thick flakes of hBN. Our results indicate that B-centers located in thin flakes can exhibit QEs higher than 40 %. Near-unity QEs are achievable under reasonable Purcell enhancement for emitters embedded in thick flakes of hBN, highlighting their promise for quantum photonics applications.
Lung transplantation models for preclinical trial (literature review)
Authors: Bunenkov N. S. , Akopov A. L. , Popov S. V. , Karpov A. A. , Minasyan S. M. , Gusejnov R. G. , Perepelitsa V. V. , Galagudza M. M. 
Published: September 2024

Lung transplantation (LT) is the only treatment for many end-stage lung diseases. Despite significant progress in transplantology and surgery, LT remains a high-tech surgical procedure performed at select research centers. Primary graft dysfunction, acute rejection, and chronic lung allograft dysfunction are serious problems that can worsen lung transplant outcomes significantly. Using animal models in experimental studies to investigate these pathologic conditions is one of the more rational approaches. A literature review was conducted in order to select a suitable model that reproduces pathologic processes developing after LT. The literature was searched and ana- lyzed in MEDLINE and Elibrary databases, and the US National Institute of Health guidelines for the period up to December 2023 were reviewed. It was found that the most frequently used models are small laboratory animal models (without LT) and large animal models (with LT).
Spider Assemblages and Diversity in Rice–Crab Cocropping Production Fields1
Authors: Ma Xiao-Hui , Guo Li , Li Zhi-Qiang 
Published: September 2024

Abstract
Rice–crab cocropping refers to a new type of ecological aquaculture technology that involves raising crabs (Eriocheir sinensis H. Milne Edwards) in rice fields. To investigate whether crabs affect the community of spiders in the rice fields, we surveyed the species composition of spiders in two types of rice production fields—a rice–crab cocropping paddy and a conventional paddy—over two growing seasons. The fields were representative of the rice fields in Panjin City, Liaoning Province, China. We collected a total of 3,406 spiders representing 27 genera and 10 families over the duration of the study. The number of spiders in rice–crab cocropping paddy fields was significantly higher than in conventional paddy fields, but there was no significant difference in the types of spiders in the two types of paddy fields. An analysis of spider community diversity using Simpson's index, Shannon–Wiener diversity index, Pielou's index, and Margalef's index revealed no significant differences between the rice–crab cocropping paddy and the conventional paddy throughout the survey period. The evenness index and the richness index exhibited a positive relationship, whereas the dominance index showed a negative relationship. The dominant species in the two cropping systems was Pirata subpiraticus Boes. et Str. (Araneae, Lycosidae). Overall, we found no impact of cocropping with crabs on the composition and characteristics of the spider community.
Program Pendewasaan Usia Perkawinan Sebagai Upaya Membentuk Keluarga Harmonis Perspekif Maqasid Al-Syariah Jasser Auda
Authors: Zaman Fakhru , Izzuddin Ahmad 
Published: September 2024

Perceraian tertinggi di Indonesia menimpa kelompok usia 20-24 tahun.Untuk menekan perceraian yang terjadi Badan Kependudukan dan Keluarga Berencana memiliki standar dalam menentukan usia ideal untuk melakukan perkawinan sehingga dapat membentuk keluarga yang harmonis. Usia Ideal 21 tahun bagi perempuan dan 25 tahun bagi laki-laki dan program BKKBN ini disebut dengan Pendewasaan Usia Perkawinan (PUP). Artikel ini memiliki tujuan untuk mendeskrippsikan program PUP dan mengetahui dapak yang ditimbulkan dari program ini. Artikel ini merupakan penelitian empiris dengan menggunakan pendekatan kualitatif, data-data diperoleh dari wawancara,buku dan dokumen. Jenis dan sumber data yang digunakan adalah sumber data primer dan sekunder ,pengolahan data menggunakan teknik pemeriksaan data, klasifikasi, verifikasi, analisis, dan kesimpulan. Artikel ini menunjukkan bahwa BKKBN Kota Malang memiliki 3 program yaitu Sekolah Siaga Keluarga (SSK), Generasi Berencana, Bina Keluarga Berencana dalam mencapai keberhasilan. Dari menjalankan program-program ini BKKBN mencapai keberhasilan dalam menekan terjadinya perkawinan dini di Kota Malang dengan meningkatnya rata-rata usia perkawinan pertama di Kota Malang. Dampak positif yang dihasilkan ini juga sejalan dengan pandangan Jasser Auda dalam maqasid syariah kontemporer menggunakan fitur sistem kognitif dalam menentukan usia perkawinan, keterbukaan dalam kehidupan bersosial, dan kemenyeluruhan dalam menentukan kedewasaan remaja. Sehingga dapat menciptakan tujuan hukum yang memenuhi hak asasi manusia dan keadilan.
ANALYSIS OF EMPLOYMENT STATUS OF COUPLE OF REPRODUCTIVE AGE ON THE INTENTIONS TO USE CONTRACEPTION IN UNMET NEED CONDITIONS
Authors: Annisa Intan Kholifatullah  , Ana Fitrotul Laili  , Miranda Feyza Nur Imania  , Elok Dwi Sulistiani  , Lutfi Agus Salim  
Published: September 2024

Based on the results of the 2021 Family Data Collection, it was revealed that Ngadiluwih District, Kediri Regency, East Java Province has a high unmet need case of 19.25%. This unmet need case is far below the target set by the RPJMN for 2019-2024. The village with the highest unmet need rate in Ngadiluwih District is Mangunrejo Village with a case of 16.89%. Various factors contribute to the unmet need rate, including socioeconomic conditions. The purpose of this study was to analyze the occupational status of the intention to use contraception in couples of childbearing age with unmet needs in Mangunrejo Village. The research was conducted with a cross-sectional approach through analytic observational methods in Mangunrejo Village in April-June 2022. The method used was interviewing and distributing questionnaires to respondents. The sample used couples of childbearing age who fit the inclusion criteria in Mangunrejo Village. As for the total of 12 respondents working and 12 respondents not working, as many as 61.3% of respondents not working have the intention to use contraception and as many as 47.8% of working respondents have the intention to use contraception. The results of the analysis showed that there was no significant relationship between the employment status of unmet need women with intention to use contraception (p=0.325). So it can be concluded that reproductive couples in Ngadiluwih District who are in unmet need condition, do not intend to use contraception who are all of those who are workers
Effects of self-controlled feedback on learning range of motion measurement techniques and self-efficacy among physical therapy students.
Authors: Yamamoto Ryohei , Imai Takaki , Yoshizato Yushin , Akizuki Kazunori 
Published: September 2024

Abstract

Background
Accurate range of motion (ROM) measurements using a universal goniometer or visual estimation are difficult for physical therapy students. Self-controlled (SC) feedback, in which learners choose whether or not to receive feedback, promotes learning more than feedback without a choice, but is underutilized in physical therapy education. Therefore, we examined the effects of SC feedback on skill acquisition of these two ROM measurements and physical therapy students' self-efficacy (SE) for ROM measurements.
Method
The participants were 30 physical therapy students randomly assigned to two groups: an SC group, in which they could choose whether to receive feedback during practice, and a Yoked (Yk) group, in which they received feedback according to a schedule created by their SC counterpart. Participants completed tests and practice of two tasks; a goniometric measurement task, in which participants measure the ROM of left knee flexion using a universal goniometer, and a visual estimation task, in which they estimate it visually. Measurement accuracy and measurement time were used as test performance for both tasks. SE for ROM measurement was measured before the start of each test. Feedback related to measurement errors was provided only during a practice in line with each group's conditions.
Results
The feedback frequency of the SC group remained high at 80.0 ± 30.3 % at the end of the practice. The accuracy and measurement time of the goniometer measurements and visual estimation improved in both groups; however, no differences were observed between the groups. In addition, the measurement accuracy was higher with goniometer measurements than with visual estimation. Furthermore, SE before the pretest did not show any relationship with the measurement accuracy of the pretest, but SE before the short-term retention test correlated with measurement accuracy at that time.
Conclusion
Although the effectiveness of SC feedback was not demonstrated, we showed that external feedback improved the accuracy of ROM measurements using a goniometer and visual estimation in physical therapy students and shortened the measurement time. It was also revealed that SE after the end of the practice was temporarily related to measurement accuracy at that time.