bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Geophysical Model for the Origin of Volcano Vent Clusters in a Colorado Plateau Volcanic Field
Authors: Deng Fanghui , Connor Charles B. , Malservisi Rocco , Connor Laura J. , White Jeremy T. , Germa Aurelie , Wetmore Paul H. 
Published: October 2017

AbstractVariation in spatial density of Quaternary volcanic vents, and the occurrence of vent clusters, correlates with boundaries in Proterozoic crust in the Springerville volcanic field (SVF), Arizona, USA. Inverse modeling using 538 gravity measurements shows that vent clusters correlate with gradients in the gravity field due to lateral variation in crustal density. These lateral discontinuities in the crustal density can be explained by boundaries in the North American crust formed during Proterozoic accretion. Spatial density of volcanic vents is low in regions of high‐density Proterozoic crust, high in areas of relatively low density Proterozoic crust, and is greatest adjacent to crustal boundaries. Vent alignments parallel these boundaries. We have developed 2‐D and 3‐D numerical models of magma ascent through the crust to simulate long‐term, average magma migration that led to the development of vent clusters in the SVF, assuming that a viscous fluid flow through a porous media is statistically equivalent to magma migration averaged over geological time in the full field scale. The location and flux from the uniform magma source region are boundary conditions of the model. Changes in model diffusivity, associated with changes in the bulk properties of the lithosphere, can simulate preferential magma migration paths and alter estimated magma flux at the surface, implying that large‐scale crustal structures, such as inherited tectonic block boundaries, influence magma ascent and clustering of volcanic vents. Probabilistic models of volcanic hazard for distributed volcanic fields can be improved by identifying crustal structures and assessing their impact on volcano distribution with the use of numerical models.
Association of Vitamin K Status Combined With Vitamin D Status and Lower‐Extremity Function: A Prospective Analysis of Two Knee Osteoarthritis Cohorts
Authors: Shea M. Kyla , Loeser Richard F. , McAlindon Timothy E. , Houston Denise K. , Kritchevsky Stephen B. , Booth Sarah L. 
Published: October 2017

ObjectiveVitamins K and D are important for the function of vitamin K–dependent proteins in joint tissues. It is unclear whether these nutrients are mutually important to functional outcomes related to knee osteoarthritis (OA). We evaluated the association of vitamin K and D sufficiency with lower‐extremity function in the Health, Aging and Body Composition knee OA substudy (Health ABC) and conducted a replication analysis in an independent cohort, the Osteoarthritis Initiative (OAI).MethodsIn Health ABC (60% female, mean ± SD age 75 ± 3 years) baseline nutrient status was measured using circulating vitamin K and 25‐hydroxyvitamin D (25[OH]D). Lower‐extremity function was assessed using the Short Physical Performance Battery (SPPB) and usual 20‐meter gait speed. In the OAI (58% female, mean ± SD age 61 ± 9 years), baseline nutrient intake was estimated by food frequency questionnaire. Lower‐extremity function was assessed using usual 20‐meter gait speed and chair stand completion time. Multivariate mixed models were used to evaluate the association of vitamin K and D status and intake with lower‐extremity function over 4–5 years.ResultsHealth ABC participants with sufficient plasma vitamin K (≥1.0 nmoles/liter) and serum 25(OH)D (≥50 nmoles/liter) generally had better SPPB scores and faster usual gait speed over followup (P ≤ 0.002). In the OAI, sufficient vitamin K and vitamin D intake combined was associated with overall faster usual gait speed and chair stand completion time over followup (P ≤ 0.029).ConclusionSufficient vitamin K status combined with sufficient vitamin D status was associated with better lower‐extremity function in 2 knee OA cohorts. These findings merit confirmation in vitamin K and D co‐supplementation trials.
Thiol–Ene Clickable Gelatin: A Platform Bioink for Multiple 3D Biofabrication Technologies
Authors: Bertlein Sarah , Brown Gabriella , Lim Khoon S. , Jungst Tomasz , Boeck Thomas , Blunk Torsten , Tessmar Joerg , Hooper Gary J. , Woodfield Tim B. F. , Groll Juergen 
Published: October 2017

AbstractBioprinting can be defined as the art of combining materials and cells to fabricate designed, hierarchical 3D hybrid constructs. Suitable materials, so called bioinks, have to comply with challenging rheological processing demands and rapidly form a stable hydrogel postprinting in a cytocompatible manner. Gelatin is often adopted for this purpose, usually modified with (meth‐)acryloyl functionalities for postfabrication curing by free radical photopolymerization, resulting in a hydrogel that is cross‐linked via nondegradable polymer chains of uncontrolled length. The application of allylated gelatin (GelAGE) as a thiol–ene clickable bioink for distinct biofabrication applications is reported. Curing of this system occurs via dimerization and yields a network with flexible properties that offer a wider biofabrication window than (meth‐)acryloyl chemistry, and without additional nondegradable components. An in‐depth analysis of GelAGE synthesis is conducted, and standard UV‐initiation is further compared with a recently described visible‐light‐initiator system for GelAGE hydrogel formation. It is demonstrated that GelAGE may serve as a platform bioink for several biofabrication technologies by fabricating constructs with high shape fidelity via lithography‐based (digital light processing) 3D printing and extrusion‐based 3D bioprinting, the latter supporting long‐term viability postprinting of encapsulated chondrocytes.
Biomimetic Inspired Core–Canopy Quantum Dots: Ions Trapped in Voids Induce Kinetic Fluorescence Switching
Authors: Saha Arpita , Oleshkevich Elena , Vinas Clara , Teixidor Francesc 
Published: October 2017

AbstractClosely packed hollow spheres connected through pillars to a CdSe quantum dot (QD) core produce channels through which ions navigate. This particular structure is well represented by [CdSe@CarbOPH(O)]@Cl/[N(Caprylyl)3Me1] indicating that in the channels between the canopy made by the carboranyl spheres (carboranylphosphinate, CarbOPH(O)) and the CdSe core exist chloride anions. Due to the close packing, the spheres produce openings. These are converted into gates because [N(Caprylyl)3Me1] acts as a plug. The [CdSe@CarbOPH(O)]@Cl/assembly is negatively charged because the Cd positive charges are outnumbered by the negative charges due to the Se, the phosphinic acid and, very importantly, the trapped chloride anions, and this negative load is compensated by the cationic surfactant. Here, it is shown that this synergism produces an unprecedented phenomenon, namely, kinetic fluorescence switching. It is observed that the material shines brightly then loses its brightness and, upon the application of kinetic energy, shines back to the maximum power. This process continues for an extended period of time, up to half a year, at least. This new type of architecture in QDs is named as core–canopy QDs. In this case, this study demonstrates one property, the kinetic fluorescence switching, as a consequence of the trapping of Cl− in the QDs channels, but other properties can be envisaged with the judicious choice of the anions or even the pillar connecting the hollow sphere with the ground.
FeCl3–Catalyzed Cascade Reactions of Cyclic Amines with 2‐Oxo‐2‐arylacetic Acids toward Furan‐2(5H)‐one Fused N,O‐Bicyclic Compounds
Authors: Shi Xiaonan , He Yan , Zhang Xinying , Fan Xuesen 
Published: October 2017

AbstractA novel and efficient synthesis of furan‐2(5H)‐one fused N,O‐containing bicyclic compounds via the cascade reactions of N‐aryl substituted cyclic amines with 2‐oxo‐2‐arylacetic acids is presented. Mechanistically, the formation of the title compounds is initiated by the in situ formation of a cyclic enamine intermediate via FeCl3/di‐tert‐butyl peroxide (TBP)/oxygen (O2)‐promoted C(sp3)−H dehydrogenation of saturated cyclic amine. Nucleophilic addition of the cyclic enamine intermediate onto 2‐oxo‐2‐arylacetic acid followed by cyclization and dehydration gives the bicyclic heterocycle products. This intermolecular oxidative annulation constitutes an extension of tertiary amine‐based Mannich‐type β‐functionalization leading to a series of N,O‐bycyclic compounds in good yields with ease.magnified image
The developmental origins of placental function
Authors: Taylor Tracey , Quinton Ann , Hyett Jonathan 
Published: October 2017

AbstractThe placenta is the link between mother and fetus and its function is central to a successful pregnancy. The predominant theory within the literature is that the development of placental dysfunction is a result of abnormal trophoblast invasion early in pregnancy. Knowledge of the development of the early placenta and the establishment of the fetomaternal circulation assists in understanding the origins of placental dysfunction which manifest later in pregnancy.Perinatally, chronic placental dysfunction may result in a growth‐restricted fetus, maternal problems such as gestational hypertension, pre‐eclampsia, eclampsia and pregnancy complications such as placental abruption, preterm labour and delivery. In addition, the growth‐restricted fetus and the mother are at an increased risk of a myriad of disorders later in life.The role of ultrasound in the assessment of first trimester pregnancy is evolving with the potential for value in the prediction of placental function in later pregnancy. This review will address two aims, first to describe the development of the placenta from fertilisation to 12 weeks’ gestation, correlating this with first trimester ultrasound findings. Second, to describe the link between placental development and function later in pregnancy.Understanding the link between early placental development and later placental function is essential in directing the focus of new research addressing the role of ultrasound in the first trimester in the prediction of adverse obstetric outcomes.
Identifizierung von Interaktoren von Ubiquitinketten
Authors: Zhao Xiaohui , Lutz Joachim , Höllmüller Eva , Scheffner Martin , Marx Andreas , Stengel Florian 
Published: October 2017

AbstractAls Ubiquitinierung bezeichnet man die Modifizierung von Proteinen durch Ubiquitin (Ub). Diese Modifizierung ist eine der vielfältigsten und am häufigsten in eukariotischen Zellen anzutreffenden posttranslationalen Modifikationen. Da Ub selbst ebenfalls als Substrat wirken kann, können Proteine durch eine Vielzahl unterschiedlicher Ubiquitinketten (Ub‐Ketten) modifiziert werden. Diese können über einen oder verschiedene Lysinreste von Ubiquitin verknüpft sein. In homogenen Ub‐Ketten sind die Ub‐Moleküle durchgehend über denselben Lysinrest verknüpft. Unter allen Kettentypen wurde dieser Typ am besten charakterisiert. Aufgrund beschränkter Zugänglichkeit sind die Funktionen von K27‐, K29‐ und K33‐verknüpften Ketten jedoch weitgehend unbekannt. Mit dem neuen Ansatz wird erstmals gezeigt, dass alle sieben homogenen Ub‐Ketten in großen Mengen herstellbar sind. Das Potenzial des Ansatzes wird deutlich durch die Identifizierung von bisher unbekannten Interaktionspartnern von K27‐, K29‐ und K33‐verknüpften Ub‐Ketten in affinitätsbasierten Proteomikstudien.
Wässrige Goldüberwachsung von Silbernanopartikeln: Vereinigung der plasmonischen Eigenschaften von Silber mit der Funktionalität von Gold
Authors: Mayer Martin , Steiner Anja Maria , Röder Falk , Formanek Petr , König Tobias A. F. , Fery Andreas 
Published: October 2017

AbstractBis heute war es nicht möglich, die optische Güte von Silbernanopartikeln mit Eigenschaften wie chemischer Stabilität, Oberflächenmodifizierbarkeit und kontrollierter Synthese in Verbindung zu bringen. Wir präsentieren eine Synthesemethode, die zukünftige Entwicklungen in Informations‐, Energie‐ und Medizintechnologie ermöglicht, in denen optische oder elektronische Eigenschaften eine zentrale Rolle spielen. Dafür kombinieren wir die goldtypischen Eigenschaften mit der Plasmonik von Silber in einem rein wasserbasierten Au/Ag/Au‐Kern‐Schale‐Schale‐System. Die Dispersität der Nanopartikel wird durch maskierte Goldkerne vorgegeben, wobei die Optik von Silber bestimmt wird. Die Überwachsung mit einer sehr dünnen, schützenden Goldschicht verleiht Oxidationsstabilität und Oberflächenfunktionalität, ohne die optischen Eigenschaften des Silbers zu beeinträchtigen. Damit werden die optische Güte von Silber und die chemische Stabilität von Gold vereint – ohne Limitierung auf eine Morphologie.
Supramolecular Recognition Allows Remote, Site‐Selective C−H Oxidation of Methylenic Sites in Linear Amines
Authors: Olivo Giorgio , Farinelli Giulio , Barbieri Alessia , Lanzalunga Osvaldo , Di Stefano Stefano , Costas Miquel 
Published: October 2017

AbstractSite‐selective C−H functionalization of aliphatic alkyl chains is a longstanding challenge in oxidation catalysis, given the comparable relative reactivity of the different methylenes. A supramolecular, bioinspired approach is described to address this challenge. A Mn complex able to catalyze C(sp3)‐H hydroxylation with H2O2 is equipped with 18‐benzocrown‐6 ether receptors that bind ammonium substrates via hydrogen bonding. Reversible pre‐association of protonated primary aliphatic amines with the crown ether selectively exposes remote positions (C8 and C9) to the oxidizing unit, resulting in a site‐selective oxidation. Remarkably, such control of selectivity retains its efficiency for a whole series of linear amines, overriding the intrinsic reactivity of C−H bonds, no matter the chain length.
Tuneable Transient Thermogels Mediated by a pH‐ and Redox‐Regulated Supramolecular Polymerization
Authors: Spitzer Daniel , Rodrigues Leona Lucas , Straßburger David , Mezger Markus , Besenius Pol 
Published: October 2017

AbstractA multistimuli‐responsive transient supramolecular polymerization of β‐sheet‐encoded dendritic peptide monomers in water is presented. The amphiphiles, which contain glutamic acid and methionine, undergo a glucose oxidase catalyzed, glucose‐fueled transient hydrogelation in response to an interplay of pH and oxidation stimuli, promoted by the production of reactive oxygen species (ROS). Adjusting the enzyme and glucose concentration allows tuning of the assembly and the disassembly rates of the supramolecular polymers, which dictate the stiffness and transient stability of the hydrogels. The incorporation of triethylene glycol chains introduces thermoresponsive properties to the materials. We further show that repair enzymes are able to reverse the oxidative damage in the methionine‐based thioether side chains. Since ROS play an important role in signal transduction cascades, our strategy offers great potential for applications of these dynamic biomaterials in redox microenvironments.
Basin‐scale distribution and haplotype partitioning in different genetic lineages of the Neotropical migratory fish Salminus brasiliensis
Authors: Rosso Juan José , Rueda Eva C. , Sanchez Sebastián , Bruno María Cecilia , Casciotta Jorge , Aguilera Gastón , Almirón Adriana E. , Ruiz Díaz Federico J. , Cancino Delia Fabiana , Bugeau Baltazar , Mabragaña Ezequiel , González‐Castro Mariano , Delpiani Matías , Díaz de Astarloa Juan Martín 
Published: October 2017

Abstract

Four valid species are currently recognized in the Neotropical migratory genus Salminus: Salminus brasiliensis, Salminus franciscanus, Salminus hilarii and Salminus affinis. However, molecular evidence strongly suggested that two different species might be contained under the taxonomic denomination Salminus brasiliensis. Therefore, the geographical distribution of each entity was evaluated in order to understand their contribution to the different stocks of major river networks in South America.
Major river networks of the La Plata River basin were explored to characterize the geographical distribution of the two genetic lineages. To characterize further the genetic partitioning within each lineage of S. brasiliensis, a haplotype analysis was conducted. The 5′ region of the mitochondrial COI gene was used as the molecular marker. In total, 45 fish samples of S. brasiliensis from 19 sites in Argentina, Brazil and Paraguay were sequenced. Additional COI sequences of S. brasiliensis, S. franciscanus and S. hilarii were gathered from public databases.
All samples of S. brasiliensis comprised two different mitochondrial lineages. Accordingly, phylogenetic tree topologies segregated the complete set of sequences into two disparate clusters. One of these clusters was far closer phylogenetically to S. hilarii than to other S. brasiliensis.
While one of the genetic lineages of S. brasiliensis seemed mostly restricted to the upper Paraná River, the other showed a widespread distribution along major river networks of the basin.
Fifteen unique haplotypes were identified and collapsed. Salminus hilarii and S. franciscanus have private haplotypes. In S. brasiliensis, each mitochondrial lineage also hosts a set of unshared haplotypes.
The sympatry of two different putative species within S. brasiliensis together with their unshared haplotypes present a difficult situation for management and conservation that calls for timely solutions.
A Rare Variant (rs933717) at FBXO31‐MAP1LC3B in Chinese Is Associated With Systemic Lupus Erythematosus
Authors: Qi Yuan‐yuan , Zhou Xu‐jie , Nath Swapan K. , Sun Celi , Wang Yan‐na , Hou Ping , Mu Rong , Li Chun , Guo Jian‐ping , Li Zhan‐guo , Wang Geng , Xu Hu‐ji , Hao Yan‐jie , Zhang Zhuo‐li , Yue Wei‐hua , Zhang Huoru , Zhao Ming‐hui , Zhang Hong 
Published: October 2017

ObjectiveRecent evidence from genetic, cell biology, and animal model studies has suggested a pivotal role of autophagy in mediating systemic lupus erythematosus (SLE). However, the genetic basis has not yet been thoroughly examined. Therefore, the aim of the present study was to identify additional susceptibility variants in autophagy‐related genes along with their functional significance.MethodsFirst, we performed a gene family–based genetic association analysis in SLE patients with the use of ImmunoChip arrays, and then we selected the most strongly associated polymorphisms for replication in additional cohorts. To identify regulatory clues, we analyzed publicly available blood expression quantitative trait locus data and Encyclopedia of DNA Elements data on transcription factor binding sites and cell type‐specific differential expression. Functional effects were tested by luciferase reporter assays, electrophoretic mobility shift assays, and differential gene expression assays.ResultsIn 14,474 samples, we observed that the rare Chinese variant rs933717T was associated with susceptibility to SLE (0.11% in cases versus 0.87% in controls; P = 2.36 × 10–10, odds ratio 0.13). The rs933717 risk allele C correlated with increased MAP1LC3B expression; increased MAP1LC3B messenger RNA was observed in SLE patients and in lupus‐prone mice. In reporter gene constructs, the risk allele increased luciferase activity up to 2.7‐3.8‐fold in both HEK 293T and Jurkat cell lines, and the binding of HEK 293T and Jurkat cell nuclear extracts to the risk allele was also increased.ConclusionWe observed a likely genetic association between light chain 3B, a widely used marker for autophagy, and susceptibility to SLE.
A Facile Cyclization Method Improves Peptide Serum Stability and Confers Intrinsic Fluorescence
Authors: Ngambenjawong Chayanon , Gustafson Heather H. , Sylvestre Meilyn , Pun Suzie H. 
Published: October 2017

AbstractPeptides are a growing class of macromolecules used in pharmaceutics. The path toward the clinical use of candidate peptides involves sequence optimization and cyclization for stability and affinity. For internalized peptides, tagging is also often required for intracellular trafficking studies, although fluorophore conjugation has an impact on peptide binding, permeability, and localization. Herein, a strategy based on cysteine arylation with tetrafluoroterephthalonitrile (4F‐2CN), which simultaneously cyclizes peptides and imparts fluorescence, is reported. The 4F‐2CN cyclization of an M2 macrophage‐targeting peptide yields, in a single step, a peptide with improved serum stability, intrinsic fluorescence, and increased binding affinity. In a murine breast cancer model, it is demonstrated that the intrinsic fluorescence from the cyclized peptide is sufficient for monitoring biodistribution by whole‐organ fluorescence imaging and cell internalization by flow cytometry.
A novel technique for simultaneous hemostasis of ipsilateral radial and ulnar artery access sites
Authors: Roberts Jonathan S. , Niu Jianli 
Published: October 2017

AbstractWith the increased use of transradial artery access (TRA) for diagnostic and coronary interventional procedures, crossover to the ipsilateral ulnar artery after TRA failure is being reported more frequently. A major challenge with ipsilateral transradial and ulnar artery access is achieving efficient patent hemostasis of both the radial and ulnar arteries at the completion of the procedure. In this report, we describe two cases of failed TRA with subsequent ipsilateral ulnar artery access. A novel and practical technique of simultaneous patent hemostasis of both the ipsilateral radial and ulnar artery access sites is described, using a QuikClot® Radial® hemostasis pad and a TR Band®.
Zn2+ Interrupts R4‐R3 Association Leading to Accelerated Aggregation of Tau Protein
Authors: Jiji A. C. , Arshad A. , Dhanya S. R. , Shabana P. S. , Mehjubin C. K. , Vijayan Vinesh 
Published: October 2017

AbstractDirect binding of divalent metal ion, especially Zn2+, have been shown to increase the rate of tau aggregation and enhance tau toxicity in cells. Hence, understanding the molecular basis of the Zn2+‐accelerated tau aggregation can potentially determine the molecular interactions modulating tau aggregation. Herein, we show that Zn2+ coordinates through the cysteine in R3 repeat and significantly accelerates the aggregation rate of the three repeat tau constructs (K19) but that the coordination is incapable of increasing the aggregation rate of the 20 amino acid peptide derived from the R3 repeat (R3) of tau. The NMR characterization of the binding of Zn2+ to K19, together with the aggregation studies with K19, R3 and R4 peptides, reveal the presence of an aggregation‐inhibitory interaction between the R3 and R4 repeat of K19. Our data show that binding of Zn2+ to R3 repeat of tau, weaken the aggregation‐inhibiting influence between R3 and R4 repeats, leading to faster aggregation of tau protein.