bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-class Active Video Game Supplementation and Adherence to Cardiac Rehabilitation
Authors: Ruivo Jorge Manuel Arsénio dos Santos , Karim Kay , O'Shea Roisin , Oliveira Rosa Celeste Santos , Keary Louis , O'Brien Claire , Gormley John Patrick 
Published: March 2017

Purpose:
The application of active video games (AVGs) during cardiac rehabilitation (CR) sessions could potentially facilitate patient adherence. The feasibility, safety, and efficacy of in-class AVG supplementation as an alternative to conventional phase 2 programs were investigated.

Methods:
A pilot, evaluator-blinded, intention-to-treat, randomized controlled trial recruited 32 low-moderate risk CR participants and allocated them to conventional or AVG-supplemented exercise. Both groups experienced equal exercise loads for 6 weeks. Patients were assessed at baseline, end of the program, and after an 8-week followup. Adherence and safety-related outcomes were the primary endpoints. Secondary outcomes included change in exercise capacity, daily physical activity (PA), energy expenditure (EE), and psychometric profiling.

Results:
Patients (males 81%; 60 ± 10 years) presented with typical cardiovascular risk factors and similar baseline characteristics. Participants did not perceive an increased risk of injury and were more interactive. At the end of the program, there was a lower tendency for dropping out (6% vs 19%, P > .05), a significant improvement in PA (322 vs 247 arbitrary acceleration units/min, P = .047) and related EE per body weight (13 vs 11 kcal/kg/d, P = .04) among AVG participants compared with controls. No significant differences between groups for adverse medical events, exercise capacity, affect toward exercise, anxiety, depression, or quality-of-life changes were reported.

Conclusions:
The additional use of AVGs during CR sessions is feasible, safe, and significantly improved daily PA and EE. A dropout reduction trend among its users, which needs to be confirmed in a larger trial, raises awareness to AVG supplementation as a promising strategy to increase CR adherence.
The Impact of a Violent Physical Assault on a Registered Nurse: Her Healing Journey and Return to Work
Authors: Graham Holly 
Published: March 2017

ABSTRACT
Healthcare practitioners are at an increased risk for workplace violence. What happens to a practitioner after a devastating physical assault from a patient in the workplace? This case report describes the impact of a violent assault on a registered nurse and her healing journey and return to the workplace. The Department of Veteran Affairs/Department of Defense “Clinical Practice Guidelines for Posttraumatic Stress Disorder” outline three categories of risk factors that are associated with the development of posttraumatic stress disorder: pretraumatic factors, peritraumatic or trauma-related factors, and posttraumatic factors. Each of these risk factors can contribute to the likelihood of an individual developing posttraumatic stress disorder after a traumatic incident and will be used to frame the discussion of this case. The registered nurse gave her full and informed consent for the author to tell her story.
The Impact of Nursing Leader’s Behavioral Integrity and Intragroup Relationship Conflict on Staff Nurses’ Intention to Remain
Authors: Kang Seung-Wan , Lee Soojin , Choi Suk Bong 
Published: March 2017

OBJECTIVEThis study tested a multilevel model examining the effect of nursing leader’s behavioral integrity and intragroup relationship conflict on staff nurses’ intent to remain.BACKGROUNDIn the challenging situation of nursing shortage, nurse executives are required to focus on the retention of nurses. No previous studies have examined the impact of nursing leader’s behavioral integrity and intragroup relationship conflict on nurses’ intention to remain.METHODSA cross-sectional survey of 480 RNs in 34 nursing units of a large public hospital in South Korea was conducted to test the hypothesized multilevel model.RESULTSNursing leader’s behavioral integrity was positively related to nurses’ intention to remain (b= 0.34,P< .001). This relationship was enhanced when the level of intragroup relationship conflict was high (b= 0.21,P< .05).CONCLUSIONSNursing leaders assigned to units with a high level of intragroup relationship conflict should endeavor to maintain their behavioral integrity to promote nurses’ intention to remain.
Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent-Treated Plasma in Critically Ill Children*
Authors: Camazine Maraya N. , Karam Oliver , Colvin Ryan , Leteurtre Stephane , Demaret Pierre , Tucci Marisa , Muszynski Jennifer A. , Stanworth Simon , Spinella Philip C. 
Published: March 2017

Objective:
To determine if the use of fresh frozen plasma/frozen plasma 24 hours compared to solvent detergent plasma is associated with international normalized ratio reduction or ICU mortality in critically ill children.

Design:
This is an a priori secondary analysis of a prospective, observational study. Study groups were defined as those transfused with either fresh frozen plasma/frozen plasma 24 hours or solvent detergent plasma. Outcomes were international normalized ratio reduction and ICU mortality. Multivariable logistic regression was used to determine independent associations.

Setting:
One hundred one PICUs in 21 countries.

Patients:
All critically ill children admitted to a participating unit were included if they received at least one plasma unit during six predefined 1-week (Monday to Friday) periods. All children were exclusively transfused with either fresh frozen plasma/frozen plasma 24 hours or solvent detergent plasma.

Interventions:
None.

Measurements and Main Results:
There were 443 patients enrolled in the study. Twenty-four patients (5%) were excluded because no plasma type was recorded; the remaining 419 patients were analyzed. Fresh frozen plasma/frozen plasma 24 hours group included 357 patients, and the solvent detergent plasma group included 62 patients. The median (interquartile range) age and weight were 1 year (0.2–6.4) and 9.4 kg (4.0–21.1), respectively. There was no difference in reason for admission, severity of illness score, pretransfusion international normalized ratio, or lactate values; however, there was a difference in primary indication for plasma transfusion (p < 0.001). There was no difference in median (interquartile range) international normalized ratio reduction, between fresh frozen plasma/frozen plasma 24 hours and solvent detergent plasma study groups, –0.2 (–0.4 to 0) and –0.2 (–0.3 to 0), respectively (p = 0.80). ICU mortality was lower in the solvent detergent plasma versus fresh frozen plasma/frozen plasma 24 hours groups, 14.5% versus 29.1%%, respectively (p = 0.02). Upon adjusted analysis, solvent detergent plasma transfusion was independently associated with reduced ICU mortality (odds ratio, 0.40; 95% CI, 0.16–0.99; p = 0.05).

Conclusions:
Solvent detergent plasma use in critically ill children may be associated with improved survival. This hypothesis-generating data support a randomized controlled trial comparing solvent detergent plasma to fresh frozen plasma/frozen plasma 24 hours.
Pulmonary Embolism Mimicking Infectious Pleuritis
Authors: Tetsuhara Kenichi , Tsuji Satoshi , Uematsu Satoko , Kamei Koichi 
Published: March 2017

Abstract
The diagnosis of pulmonary thromboembolism (PE) is often delayed because it is usually misdiagnosed as pneumonia or deep vein thrombosis. We report an unusual case of PE misdiagnosed as viral pleuritis on the first arrival at the emergency department (ED) in our hospital. A 14-year-old girl with no previous significant medical history was referred to the ED with pleuritic and chest pain with low-grade fever 4 days before admission. Echography showed a small amount of left pleural effusion. A 12-lead electrocardiogram was normal. She received a diagnosis of viral pleuritis. Two days before admission, she revisited ED with dyspnea and exacerbated pain. Echography showed slight increase in left pleural effusion. She had the same diagnosis. The chest pain remained at the same level. On the day of admission, she presented to ED with vomiting, watery diarrhea, abdominal pain, chest pain, and respiratory distress. Laboratory findings showed hypoalbuminemia and proteinuria. Echography showed a moderate amount of pleural effusion on both sides and no dilatation of the right cardiac ventricle. Contrast-enhanced chest computed tomography was performed to search the cause of the respiratory distress, which showed filling defects with contrast material in pulmonary arteries. A 12-lead electrocardiogram showed an S1Q3T3 pattern. She received a diagnosis of PE caused by nephrotic syndrome. Pulmonary thromboembolism can mimic infectious pleuritis and lead to misdiagnosis and/or delayed diagnosis. Thus, risk factors of PE should be considered in pediatric patients presenting with symptoms suggesting infectious pleuritis.
Understanding Brain Reorganization in Infants With Perinatal Stroke Through Neuroexcitability and Neuroimaging
Authors: Chen Chao-Ying , Georgieff Michael , Elison Jed , Chen Mo , Stinear James , Mueller Bryon , Rao Raghavendra , Rudser Kyle , Gillick Bernadette 
Published: March 2017

Purpose:The primary aim of this proposed study is to evaluate brain reorganization patterns in infants with perinatal stroke between 3 and 5 months of age using transcranial magnetic stimulation and magnetic resonance imaging, with the addition of the General Movements Assessment. A secondary aim is to demonstrate feasibility and safety of infant-appropriate brain assessment protocols.Methods:Ten infants with perinatal stroke will be enrolled. In this exploratory study, infants will first receive magnetic resonance imaging scanning during natural sleep to examine their corticospinal tract integrity. Infants will then receive transcranial magnetic stimulation to assess their corticomotor excitability. A General Movements Assessment video of at least 5 minutes will also be recorded.Discussion:Study results will enhance our understanding of brain reorganization in infants with perinatal stroke. We expect these results will also guide the development of early interventions designed to mitigate maladaptive neuroplastic changes and improve long-term motor outcomes.
Data, Staff, and Money: Leadership Reflections on the Future of Public Health Informatics
Authors: Leider Jonathon P. , Shah Gulzar H. , Williams Karmen S. , Gupta Akrati , Castrucci Brian C. 
Published: March 2017

Context:
Health informatics can play a critical role in supporting local health departments' (LHDs') delivery of certain essential public health services and improving evidence base for decision support. However, LHDs' informatics capacities are below an optimum level. Efforts to build such capacities face ongoing challenges. Moreover, little is known about LHD leaders' desires for the future of public health informatics.

Objectives:
Conduct a qualitative analysis of LHDs' future informatics plans, perceived barriers to accomplishing those plans, and potential impact of future advances in public health informatics on the work of the public health enterprise.

Methods:
This research presents findings from 49 in-depth key informant interviews with public health leaders and informatics professionals from LHDs, representing insights from across the United States. Interviewees were selected on the basis of the size of the population their LHD serves, as well as level of informatics capacity. Interviews were transcribed, verified, and double coded.

Results:
Major barriers to doing more with informatics included staff capacity and training, financial constraints, dependency on state health agency, and small LHD size/lack of regionalization. When asked about the role of leadership in expanding informatics, interviewees said that leaders could make it a priority through (1) learning more about informatics and (2) creating appropriate budgets for integrated information systems. Local health department leaders said that they desired data that were timely and geographically specific. In addition, LHD leaders said that they desired greater access to clinical data, especially around chronic disease indicators.

Conclusions:
Local health department leadership desires to have timely or even real-time data. Local health departments have a great potential to benefit from informatics, particularly electronic health records in advancing their administrative practices and service delivery, but financial and human capital represents the largest barrier. Interoperability of public health systems is highly desirable but hardly achievable in the presence of such barriers.
Three-Dimensional Self-Navigated T2 Mapping for the Detection of Acute Cellular Rejection After Orthotopic Heart Transplantation
Authors: van Heeswijk Ruud B. , Piccini Davide , Tozzi Piergiorgio , Rotman Samuel , Meyer Philippe , Schwitter Juerg , Stuber Matthias , Hullin Roger 
Published: March 2017

Background
T2 mapping is a magnetic resonance imaging technique measuring T2 relaxation time, which increases with the myocardial tissue water content. Myocardial edema is a component of acute cellular rejection (ACR) after heart transplantation. This pilot study compares in heart transplantation recipients a novel high resolution 3-dimensional (3D) T2-mapping technique with standard 2-dimensional (2D) T2-mapping for ACR detection.

Methods
Consecutive asymptomatic patients (n = 26) underwent both 3D T2 mapping and reference 2D T2 mapping magnetic resonance imaging on the day of endomyocardial biopsy (EMB). 3D T2 maps were obtained at an isotropic spatial resolution of 1.72 mm (voxel volume 5.1 mm3). 2D and 3D maps were matched anatomically, and maximum segmental T2 values were compared blinded to EMB results. In addition, all 3D T2 maps were rendered as 3D images and inspected for foci of T2 elevation.

Results
T2 values of segments from 2D and reformatted 3D T2 maps agreed (p > 0.5). The highest 2D segmental T2 values were 49.9 ± 4.0 ms (no ACR = 0R, n = 18), 48.9 ± 0.8 ms (mild ACR = 1R, n = 3), and 65.0 ms (moderate ACR = 2R). Rendered 3D T2 maps of cases with 1R showed foci with significantly elevated T2 signal (T2 = 58.2 ± 3.6 ms); 5 cases (28%) in the 0R group showed foci with increased T2 values (>2 SD above adjacent tissue) that were not visible on the 2D T2 maps.

Conclusions
This pilot study in a small cohort suggests equivalency of standard segmental analysis between 3D and 2D T2-mapping. 3D T2 mapping provides a spatial resolution that permits detection of foci with elevated T2 in patients with mild ACR.
Low-Density Lipoprotein Receptor-Related Protein 4-Positive Myasthenia Gravis in a Double-Seronegative, Electromyography-Negative Patient
Authors: Kruger Joshua M. , Karussis Dimitrios , Zisimopoulou Paraskevi , Petrou Panayiota 
Published: March 2017

Abstract:
We describe a patient with ocular myasthenia gravis, where single-fiber electromyography and testing for acetylcholine receptor and muscle-specific kinase antibodies were negative. However, antibodies to low-density lipoprotein receptor-related protein 4 (LRP4) were positive, and this prompted appropriate management. We recommend that testing for LRP4 antibodies be considered when the clinical suspicion for myasthenia gravis is high despite negative conventional diagnostic tests.
Biosynthesis of Isonitrile Lipopeptides by Conserved Non-ribosomal Peptide Synthetase Gene Clusters inActinobacteria
Authors: Harris Nicholas C. , Sato Michio , Herman Nicolaus A. , Twigg Frederick , Cai Wenlong , Liu Joyce , Downey Jordan , Khalaf Ryan , Martin Joelle , Koshino Hiroyuki , Zhang Wenjun 
Published: March 2017

AbstractA putative lipopeptide biosynthetic gene cluster is conserved in many species ofActinobacteria, includingMycobacterium tuberculosisandM. marinum, but the specific function of the encoding proteins has been elusive. Using bothin vivoheterologous reconstitution andin introbiochemical analyses, we have revealed that the five encoding biosynthetic enzymes are capable of synthesizing a new family of isonitrile lipopeptides (INLPs) through a thio-template mechanism. The biosynthesis features the generation of isonitrile from a single precursor Gly promoted by a thioesterase and a non-heme iron(II)-dependent oxidase homologue, and the acylation of both amino groups of Lys by the same isonitrile acyl chain facilitated by a single condensation domain of a non-ribosomal peptide synthetase (NRPS). In addition, the deletion of INLP biosynthetic genes inM. marinumhas decreased the intracellular metal concentration, suggesting the role of this biosynthetic gene cluster in metal transport.Significance StatementMycobacterium tuberculosisis the leading causative agent of tuberculosis (TB), of which millions of deaths occur annually. A putative lipopeptide biosynthetic gene cluster has been shown to be essential for the survival of this pathogen in hosts, and homologous gene clusters have also been found in all pathogenic mycobacteria and other species ofActinobacteria. We have identified the function of these gene clusters in making a new family of isonitrile lipopeptides. The biosynthesis has several unique features, including an unprecedented mechanism for isonitrile synthesis. Our results have further suggested that these biosynthetic gene clusters play a role in metal transport, and thus have shed light on a new metal transport system that is crucial for virulence of pathogenic mycobacteria.
Corrosion inhibition of Monel 400 in hydrochloric solution by some green leaves
Authors: Kherraf Sihem , Zouaoui Emna , Medjram Mohamed Salah 
Published: March 2017

PurposeThe purpose of this study was to investigate the inhibitive action of some green leaves on Monel 400 alloy in acidic media.Design/methodology/approachGreen leaves ofMespilus japonica,Ricinus communis LandVitis viniferawere immersed in methanol solutions, separately, and filtrated after 48 h of immersion; the obtained filtrates were examined as corrosion inhibitors of Monel 400 alloy in hydrochloric acid solution (1.0M HCl). The performance of these inhibitors was evaluated using electrochemical impedance spectroscopy and potentiodynamic polarization. The effect of temperature on corrosion behavior of Monel 400 was also studied.FindingsThe results obtained showed that all tested inhibitors performed as good corrosion inhibitors. The inhibition process is attributed to the adsorption of the inhibitors on Monel surface. The adsorption behavior was found to follow Langmiur isotherm. The inhibition efficiencies of extracts increased with increasing the concentration of each inhibitor and deceased with increasing the temperature.Practical implicationThese inhibitors could have application in industries where hydrochloric solutions were used to remove the surface impurities of Monel 400.Originality/valueThis paper helps to find new corrosion inhibitors that are safe and eco-friendly.
The moderating impact of emotions on customer equity drivers and loyalty intentions
Authors: Razzaq Zohaib , Yousaf Salman , Hong Zhao 
Published: March 2017

Purpose
The purpose of this paper is to investigate the significant contribution of emotions along with other conventional loyalty drivers on the loyalty intentions.

Design/methodology/approach
The influence of three conventional loyalty drivers, i.e., value equity, brand equity, relationship equity on loyalty intentions was investigated by further exploring the moderating effects of negative and positive emotions. A sample of 834 Pakistani consumers in the supermarkets and banking industries was studied employing store-intercept survey design.

Findings
Consumer behavior is driven by emotions in both the supermarkets and banking context. Thus, in order to better predict customer loyalty intentions, the emotional component is crucial and should be included along with other cognitive components.

Practical implications
Since customers’ emotional responses throughout service delivery are strongly linked to loyalty, therefore supermarkets and bank service managers need to make sure that the customers experience with their services as pleasurable as possible and for this purpose, customer service employees need to be trained in order to better understand the customers’ emotional responses during the course of service delivery process.

Originality/value
The present study complements the existing literature regarding the role of emotions in service settings and offers a new point of view for the linkage among emotions, customer equity drivers and customer loyalty intentions.
Exploring the service profit chain in a Thai bank
Authors: Benjarongrat Pichate , Neal Mark 
Published: March 2017

PurposeThe purpose of this paper is to explore the service profit chain (SPC) in a Thai bank, to identify which service features customers understand to be most important in their customer satisfaction and engagement. Through this it is intended to evaluate and refine the SPC model.Design/methodology/approachThe research involved two phases: a qualitative inductive process of interviews with bank customers to identify what they considered to be the most important aspects of service in their own customer satisfaction/engagement; second, a survey phase, which theoretically developed these aspects of service, and operationalized them as variables for testing in a refined SPC model.FindingsThe key service features for customers in their satisfaction and engagement were found to be convenience, courtesy, competence and internal branding. All had positive relationships with customer satisfaction/customer engagement. Customer engagement/satisfaction were further found to correlate with customer retention and acquisition. Interestingly, whereas all four service variables correlated with customer engagement and satisfaction, two of the variables – courtesy and internal branding – had stronger relationships with customer engagement.Practical implicationsThe inductive modeling and refinement of the SPC approach can be employed in different companies and cultural contexts to identify which features of service are most important to customers in influencing their customer satisfaction/engagement.Originality/valueThis is the first study to use/evaluate the SPC approach in the Thai banking context; the first to use inductive methods to identify relationships between service features and customer satisfaction/engagement; and the first to examine courtesy, competence, convenience and internal branding in a holistic model with customer satisfaction/engagement and customer retention/acquisition.