bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of interventions to foster physician resilience
Authors: Fox Susan , Lydon Sinéad , Byrne Dara , Madden Caoimhe , Connolly Fergal , O’Connor Paul 
Published: October 2017

AbstractThis review aimed to synthesise the literature describing interventions to improve resilience among physicians, to evaluate the quality of this research and to outline the type and efficacy of interventions implemented. Searches were conducted in April 2017 using five electronic databases. Reference lists of included studies and existing review papers were screened. English language, peer-reviewed studies evaluating interventions to improve physician resilience were included. Data were extracted on setting, design, participant and intervention characteristics and outcomes. Methodological quality was assessed using the Downs and Black checklist. Twenty-two studies were included. Methodological quality was low to moderate. The most frequently employed interventional strategies were psychosocial skills training and mindfulness training. Effect sizes were heterogeneous. Methodologically rigorous research is required to establish best practice in improving resilience among physicians and to better consider how healthcare settings should be considered within interventions.
Dispersion relations and wave propagation in photonic hypercrystals
Authors: Ali Munazza Zulfiqar 
Published: October 2017

A photonic hypercrystal is a subwavelength periodic structure consisting of alternate layers of hyperbolic metamaterial and dielectric material. The structure can be treated as an effective medium as well as a periodic medium. Since two length scales are involved, the better treatment is to treat the hyperbolic metamaterial as an effective medium and the overall structure as a periodic medium. The dispersion relations are derived and plotted to show the appearance of propagating bands and gaps in the frequency and wave vector domains. Then using the transfer matrix approach, the transmissivity versus the frequency plot for propagating waves and grayscale plot of the transmission coefficient in the frequency versus wave vector plane for the evanescent waves are plotted and analyzed.
Jumping the Barrier: Modeling Drug Penetration across the Blood–Brain Barrier
Authors: Peer Cody J. , Chau Cindy H. , Figg William D. 
Published: October 2017

Abstract
Determining the penetration of drugs across the blood–brain barrier is a significant challenge in central nervous system drug development. The use of a mechanistic physiologically based pharmacokinetic model can predict drug exposures in the brain without needing in situ drug measurements. Clin Cancer Res; 23(24); 7437–9. ©2017 AACR.
See related article by Li et al., p. 7454
Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide Levels in Heart Failure Patients With and Without Atrial Fibrillation
Authors: Kristensen Søren Lund , Jhund Pardeep S. , Mogensen Ulrik M. , Rørth Rasmus , Abraham William T. , Desai Akshay , Dickstein Kenneth , Rouleau Jean L. , Zile Michael R. , Swedberg Karl , Packer Milton , Solomon Scott D. , Køber Lars , McMurray John J.V. 
Published: October 2017

Background
Patients with heart failure (HF) and atrial fibrillation (AF) have higher circulating levels of NT-proBNP (N-terminal pro-B-type natriuretic peptide) than HF patients without AF. There is uncertainty about the prognostic importance of a given concentration of NT-proBNP in HF patients with and without AF. We investigated this question in a large cohort of patients with HF and reduced ejection fraction.

Methods and Results

We studied 14 737 patients with HF and reduced ejection fraction and a measurement of NT-proBNP at time of screening, enrolled in either the PARADIGM-HF trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) or the ATMOSPHERE trial (Aliskiren Trial to Minimize Outcomes in Patients With Heart Failure), of whom 3575 (24%) had AF on their baseline ECG. Median (Q1, Q3) levels of NT-proBNP were 1817 pg/mL (1095–3266 pg/mL) in those with AF and 1271 pg/mL (703–2569 pg/mL) in those without (
P
<0.0001). Patients with AF were older (67 versus 62 years), had worse New York Heart Association class (III/IV; 36% versus 24%), and experienced fewer previous HF hospitalizations (52% versus 61%) or myocardial infarction (30% versus 46%); all
P
<0.001. We categorized patients with and without AF into 5 NT-proBNP bands: <400, 400 to 999 (reference), 1000 to 1999, 2000 to 2999, and ≥3000 pg/mL. For the primary composite outcome of cardiovascular death or HF hospitalization, event rates differed for patients with and without AF in the lowest band (<400 pg/mL; 8.2 versus 5.0 per 100 patient-years), but not for the higher bands (400–999 pg/mL, 7.4 versus 7.7 per 100 patient-years; 1000–1999 pg/mL, 9.8 versus 11.4 per 100 patient-year; 2000–2999 pg/mL, 13.5 versus 13.4 per 100 patient-years; ≥3000 pg/mL, 22.7 versus 23.0 per 100 patient-years). These findings were consistent whether NT-proBNP was examined as a categorical or continuous variable and before and after adjustment for other prognostic variables. We found similar results for the components of the composite outcome and all-cause mortality.

Conclusions
HF and reduced ejection fraction patients with AF had higher NT-proBNP than those without AF. However, above a concentration of 400 pg/mL (representing most patients in each group), NT-proBNP had similar predictive value for adverse cardiovascular outcomes, irrespective of AF status.

Clinical Trial Registration

URL:
https://www.clinicaltrials.gov
. Unique identifier NCT00853658 (ATMOSPHERE) and NCT01035255 (PARADIGM-HF).
Neuroimaging Correlates of Cerebral Microbleeds
Authors: Graff-Radford Jonathan , Simino Jeannette , Kantarci Kejal , Mosley Thomas H. , Griswold Michael E. , Windham B. Gwen , Sharrett A. Richey , Albert Marilyn S. , Gottesman Rebecca F. , Jack Clifford R. , Vemuri Prashanthi , Knopman David S. 
Published: October 2017

Background and Purpose—
Cerebral microbleed (CMB) location (deep versus strictly lobar) may elucidate underlying pathology with deep CMBs being more associated with hypertensive vascular disease and lobar CMBs being more associated with cerebral amyloid angiopathy. The objective of this study was to determine whether neuroimaging signs of vascular disease and Alzheimer pathology are associated with different types of CMBs.

Methods—
Among 1677 nondemented ARIC (Atherosclerosis Risk in Communities) participants (mean age=76±5 years; 40% men; 26% black) with 3-Tesla MRI scans at the fifth examination (2011–2013), we fit multinomial logistic regression models to quantify relationships of brain volumes (Alzheimer disease signature regions, total gray matter, frontal gray matter, and white matter hyperintensity volumes), infarct frequencies (lacunar, nonlacunar, and total), and apolipoprotein E (number of ε4 alleles) with CMB location (none, deep/mixed, or strictly lobar CMBs). Models were weighted for the sample selection scheme and adjusted for age, sex, education, hypertension, ever smoking status, diabetes mellitus, race site membership, and estimated intracranial volume (brain volume models only).

Results—
Deep/mixed and strictly lobar CMBs had prevalences of 8% and 16%, respectively. Larger white matter hyperintensity burden, greater total infarct frequency, smaller frontal volumes (in women only), and smaller total gray matter volume were associated with greater risk of both deep and lobar CMBs relative to no CMBs. Greater white matter hyperintensity volume was also associated with greater risk of deep relative to lobar CMBs. Higher lacunar and nonlacunar infarct frequencies were associated with higher risk of deep CMBs, whereas smaller Alzheimer disease signature region volume and apolipoprotein E ε4 homozygosity were associated with greater risk of lobar CMBs.

Conclusions—
CMBs are a common vascular pathology in the elderly. Markers of hypertensive small-vessel disease may contribute to deep CMBs while cerebral amyloid angiopathy may drive development of lobar CMBs.
The Agdal of Marrakesh (Twelfth to Twentieth Centuries): An Agricultural Space for Caliphs and Sultans. Part 1: History
Authors: Navarro Julio , Garrido Fidel , Almela Íñigo 
Published: October 2017

The Agdal is an enormous estate, located south of Marrakesh, that has survived from the twelfth century to the present. Historically it was used for agricultural production and related functions, and included pleasure gardens, pools, mills, and seasonal residences. This study presents the results of a multi-year survey of the Agdal’s water bodies, its place within the regional hydraulic system of khaṭṭāras, cultivation practiced there throughout the centuries, and the internal organization of its land and more than forty buildings. This archaeological approach is joined with a study of manuscript and published sources to give a comprehensive history of the Agdal, one of the most important historic landscapes in the Islamic world.
Utilization of an Integrated Electronic Health Record in the Emergency Department to Increase Prospective Medication Order Review by Pharmacists
Authors: Barra Megan E. , Culbreth Sarah E. , Sylvester Katelyn W. , Rocchio Megan A. 
Published: October 2017

Purpose: The objective of this study is to evaluate the impact of an integrated medical record system on prospective medication order verification by pharmacists in the emergency department (ED) of a level I trauma center. Methods: This was a single-center retrospective analysis comparing medication orders verified by a pharmacist during a 7-day period in 2013 (phase I) versus 2015 (phase II). Outcome measures include the percentage of medication orders reviewed by a pharmacist prior to administration and time from order entry to each of the following: pharmacist review, medication procurement from an automated dispensing cabinet (ADC), and medication administration. Results: In total, 5450 medication orders were included in the study. The percentage of medication orders reviewed by a pharmacist prior to administration increased from 51.8% to 94% in phase I versus phase II, respectively ( P < .001). Median time from order entry to pharmacist verification decreased from 13 to 4 minutes in phase I versus phase II, respectively ( P < .001). Time from order entry to ADC dispense increased from a median of 9 minutes in phase I to 15 minutes in phase II ( P < .001). Time from order entry to nursing administration increased from a median time of 15 minutes in phase I to 23 minutes in phase II ( P < .001). Conclusion: Implementation of prospective pharmacist order verification in the ED increased the percentage of medications reviewed by a pharmacist prior to administration and improved pharmacist efficiency in the medication verification process. This increase in pharmacist review was associated with a marginal increase in time to medication procurement and administration.
Dissolution kinetics of hydrated calcium aluminates (AFm-Cl) as a function of pH and at room temperature
Authors: Marty Nicolas C. M. , Grangeon Sylvain , Lerouge Catherine , Warmont Fabienne , Rozenbaum Olivier , Conte Thibauld , Claret Francis 
Published: October 2017

AbstractThe determination of reliable weathering/dissolution rates for cement phases is of fundamental importance for the modelling of the temporal evolution of both radioactive waste repositories and CO2 geological storage sites (e.g. waste matrix, plug in boreholes). Here, the dissolution kinetics of AFm-Cl (hydrated calcium aluminates containing interlayer Cl) has been studied using flow-through experiments conducted at pH values ranging from 9.2 to 13. Mineralogical (XRD) and chemical (EPMA, TEM) analyses have been performed to determine the evolution of the phases during the dissolution experiments. For pH values between 10 and 13, the dissolution of AFm-Cl is congruent (i.e. Ca/Al ratios close to 2 both for solids and outlet concentrations). In contrast, the precipitation of amorphous Al-phases and possibly amorphous mixed Al/Ca phases is observed at pH 9.2, leading to Ca/Al ratios in the outlet solutions higher than those of the initial solid. Therefore, at pH 9.2, even if Cl–/OH– exchange occurs, estimation of dissolution rate from released Cl appears to be the best proxy. Dissolution rates were normalized to the final specific surface areas (ranging from 6.1 to 35.4 m2 g−1). Dissolution rate appears to be pH-independent and therefore the far-from-equilibrium dissolution rate at room temperature is expressed as: logR(mol m–2 s–1) = –9.23 ± 0.18
Three-dimensional study by synchrotron radiation computed tomography of melt distribution in samples doped to enhance contrast
Authors: Ikeda Susumu , Nakano Tsukasa , Tsuchiyama Akira , Uesugi Kentaro , Nakashima Yoshito , Nakamura Koichi , Yoshida Hideto , Suzuki Yoshio 
Published: October 2017

AbstractThe three-dimensional distribution of melt in partially molten synthetic samples compositionally corresponding to diopside (90 wt.%)–anorthite (10 wt.%) and doped with PbO, WO3, MoO3, or Cs2O to enhance contrast was studied by X-ray computed tomography (CT) with synchrotron radiation. The heavy elements were strongly concentrated in the melt and contributed to an increase of the X-ray linear attenuation coefficient (LAC) of it. PbO was found to be compatible with silicate melt (>20 wt.% in solution) and incompatible with diopside crystals. Other oxides WO3 (∼10 wt.%), MoO3 (∼5 wt.%) and Cs2O (< 5 wt.%) are also soluble only in the melt. Such doping is useful not only for LAC control in X-ray CT measurements, but also for systematic control of the structure (wetting properties, distribution and connectivity) of partial melt. This technique gives basic information for discussion of the 3D distribution of partial melt having different wetting properties. As PbO was most effective in visualization of the diopside–anorthite partially molten system, CT images of the PbO-bearing sample were used for further 3D investigation of distribution. A distribution of dihedral angles at solid-melt-solid triple junctions ranging from 22 to 55° was observed with the 3D data. This range in angle distribution was probably caused by anisotropy of crystals and the result supports the argument that there is some limitation in a theoretical framework of stereology which estimates the 3D structure based on 2D observations. Investigators have begun to apply X-ray CT to the study of the 3D distribution of partial melts in rocks using synchrotron radiation. Our study on the effect of doping is one approach for developing a technique to investigate 3D melt distribution.
Complete genome sequence of Thermotoga sp. strain RQ7
Authors: Xu Zhaohui , Puranik Rutika , Hu Junxi , Xu Hui , Han Dongmei 
Published: October 2017

AbstractThermotoga sp. strain RQ7 is a member of the family Thermotogaceae in the order Thermotogales. It is a Gram negative, hyperthermophilic, and strictly anaerobic bacterium. It grows on diverse simple and complex carbohydrates and can use protons as the final electron acceptor. Its complete genome is composed of a chromosome of 1,851,618 bp and a plasmid of 846 bp. The chromosome contains 1906 putative genes, including 1853 protein coding genes and 53 RNA genes. The genetic features pertaining to various lateral gene transfer mechanisms are analyzed. The genome carries a complete set of putative competence genes, 8 loci of CRISPRs, and a deletion of a well-conserved Type II R-M system.
Clinical and laboratory assessment of a patient with thrombocytosis
Authors: Appleby Niamh , Angelov Daniel 
Published: October 2017

Elevated platelet counts are frequently encountered in hospital medicine and arise from both physiological and pathological mechanisms. Thrombocytosis may be secondary, reflecting an inflammatory state, iron deficiency, recent surgery or point towards an underlying neoplasm. Thrombocytosis may be the presenting sign of solid tumours and haematological conditions. The discovery of the activating mutations affecting thrombopoiesis led to greater understanding of the pathobiology of essential thrombocythaemia and other myeloproliferative neoplasms. The investigation of suspected primary thrombocytosis has evolved to include testing for these disease-associated mutations. Therapy for patients with essential thrombocythaemia aims to reduce their risk of thrombotic complications by addressing cardiovascular risk factors, and using antiplatelet agents and, in selected patients, cytoreductive therapy. This article provides a logical approach to distinguishing reactive or secondary thrombocytosis from thrombocytosis associated with an underlying myeloproliferative neoplasm and gives an overview of the management of essential thrombocythaemia.
The psychological nature of seizure conditions
Authors: Gurr Birgit , Tanskanen Sanna-Leena 
Published: October 2017

Background/Aims:Epilepsy is a long-term health condition that is associated with multiple biological, psychological and behavioural factors. Psychogenic or non-epileptic conditions have caused much debate and controversy among clinicians and researchers. This paper outlines comprehensive assessments with the aim of describing the psychological nature of different types of seizure conditions.Methods:The retrospective study reports on a range of self-report psychometric data of 26 patients with epileptic, non-epileptic, or both types of seizure conditions. The Hospital and Anxiety and Depression Scale, the Dissociative Experiences Scale and the Emotional Processing Scale were used to assess psychological functioning and emotional distress. The Quality of Life in Epilepsy Inventory and the MOS Short-Form Health Survey 36 were administered to evaluate subjective experiences related to quality of life and disability.Results:Epileptic and non-epileptic seizures are formulated in the background of biopsychosocial stress theories. The questionnaire outcomes revealed complex profiles. All patient groups reported reduced quality of life. Differential patterns of psychological distress were discovered for both diagnostic groups.Conclusion:The findings from this heterogeneous clinical population suggest that patients with epileptic and non-epileptic conditions demonstrate secondary psychological and functional difficulties. Future systematic research is required to establish valid measures of long-term psychosocial strain and to provide evidence for the link between maladaptive physiological mechanisms and psychological problems (and vice versa).
Power asymmetries in intercultural theatre in Taiwan: Flagship productions and audience response
Authors: Wang Wei-Chih 
Published: October 2017

Abstract
Given Taiwan’s colonial past, modern Taiwanese theatre has never been purely aesthetic. Instead, it is largely sociopolitical, providing an alternative space that indirectly transforms local people’s contestations of identity onstage, where practitioners reimagine or even reinvent Taiwan. Taking Taiwan as an intersection of transnational forces, I present an analysis of the ways in which power is negotiated in intercultural theatrical performance. In particular, I examine two ‘flagship’ productions of the Taiwan International Festival of Art: Orlando (2009) directed by Robert Wilson (1941–present), and La Dame aux Camélias (2011) directed by Suzuki Tadashi (1939–present). With these two productions, I explore the subtle ways in which modern Taiwanese theatre embodies both culturally universal identities and postcolonial struggles in Taiwanese contexts. By engaging with the most influential research on intercultural theatre and contextualizing these two flagship productions, I argue for moving away from an aesthetic to a more context-sensitive analysis of intercultural theatre productions that includes the perspectives and agency of practitioners and spectators. Ultimately, my analysis reveals the intense power negotiation of agency between three participating groups: foreign directors of global fame, local practitioners and spectators.
When localism meets racism: The controversy caused by the music video Foreigner
Authors: Yueh Hsin-I Sydney 
Published: October 2017

Abstract
The controversy caused by the music video Foreigner represents a tug of war between the western-dominated global value system and the culturally situated local pride. The controversy stems from the symbolic meaning of the music group, Nine One One. The rise of Nine One One is a result of the convergence of three forces: the localization of Taiwanese hip hop culture; the development of the digital music production business; the ongoing evolution of the taike concept and Taiwanese consciousness. This personal response article juxtaposes an American female’s criticism of the music video as racist and Taiwanese netizens’ reactions against the backdrop of a growing taike culture in order to present and question the hegemonic interpretation of the controversy. I will argue that the often-unnoticed discrimination held by Taipei cultural elites towards other Taiwanese citizens plays a key role in understanding the controversy.
Sara Pennoyer: Twentieth-century retail and advertising executive and her creation, Polly Tucker, Merchant
Authors: Matheson Rebecca Jumper 
Published: October 2017

Abstract
Twentieth-century American retail and advertising executive Sara Pennoyer gained varied fashion industry experience during the course of a long career, which included stints as promotion director at Harper’s Bazaar, advertising copywriter, buyer, fashion reporter and even novelist. In the 1930s and the 1940s, Pennoyer served as sales promotion manager, and later vice president, for New York specialty store Bonwit Teller, where her novel in 1937, Polly Tucker: Merchant, and the related campaign were a highlight of her career. Pennoyer’s work was grounded on a firm foundation of writing ability, paired with a creative ability to connect to consumers. Near the end of her career, Pennoyer headed her own advertising agency. Sara Pennoyer was one of the now little-known twentieth-century women who forged a fruitful career path in the American retail industry.
A queer aesthetic: Representations of gender and sexuality in Sadie Lee’s Tomboys and Crossdressers
Authors: Grigorovich Alisa 
Published: October 2017

Abstract
This article examines a series of paintings created by the artist Sadie Lee. Although these paintings are over twenty years old, their subject matter has salience to continuing debates about the nature of the relationship (if any) between gender and sexuality, and the role of clothing and physical appearance in self-representation, recognition and subjectivity. In focusing on queer women who do not easily fit within the homonormative cultural logics of mainstream lesbian culture, Lee directly challenges and enlarges contemporary understandings of current and historical queer subjectivities and sexualities. Drawing on recent scholarship regarding queer utopian looking practices and emotion, this article seeks to contribute towards ongoing debates about lesbian representation within popular culture by exploring the queer aesthetic of Lee’s paintings. What is ultimately argued is that Lee’s paintings generate an affective experience that offers us with a critical opportunity to disrupt the ‘straight time’ of the mainstream visual canon.
Book Reviews
Authors: Miller Jordan Forrest , Walerstein Rachel , Cocarla Sasha 
Published: October 2017

Abstract
Out Online: Trans Self-Representation and Community Building on Yo uTube, Tobias Raun (2016) New York: Routledge, 228 pp., ISBN: 9781472466761, h/bk, $149.95
Queer: A Graphic History, Meg-John Barker and Julia Scheele (2016) London: Icon Books, 175 pp., ISBN: 9781785780714, h/bk, US $17.95; ISBN: 9781785780714, p/bk, UK £11.99
The Revolting Child in Horror Cinema: Yo uth Rebellion and Queer Spectatorship, Andrew Scahill (2015) New York: Palgrave Macmillan, 193 pp., ISBN: 9781137488503, h/bk, $95.00