bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drunkards and Singers: A Mongolian Battle of Sounds
Authors: Legrain Laurent 
Published: January 2017

AbstractWhen I conducted fieldwork among the Darhad of northern Mongolia my informants repeatedly asserted that after a good singer’s performance even the most badly intoxicated lad stands still and keeps silent. In this article, I make three points in order to explain why this claim was made. In the first one, I show that the main concern about singing performance at social gatherings is not about revealing the singer’s inner emotional realm but rather about crafting a collective feeling that has the ability to make people temporarily shed their otherness and converge. The problem with drunkards lies in the fact that they are unable to participate and even noisily impede this rite of convergence. The main reason is that they are not sufficiently detached from their own inner realm. I then put the concept of noise in context, arguing that it forms the repulsive pole of a Mongolian sonic continuum. In my last point, I stress the fact that according to Mongolian linguistic ideology, noise brings misfortune to the entire community. That is why good singers must win their battle against drunkards.
Characteristics of Beta-blocker Treatment in Cardiac Patients with Concomitant Chronic Obstructive Pulmonary Disease
Authors: Frigy Attila , Mezei Katalin , Kocsis Ildikó , Máthé Lehel 
Published: January 2017

Abstract

Background: Recent scientific data demonstrated a potential beneficial effect of beta-blocker (BB) therapy in cardiac patients with chronic obstructive pulmonary disease (COPD). Our aim was to characterize the use of beta-blockers in these patients, in “real-life” conditions.

Material and methods: We collected retrospectively the data of 60 consecutive cardiac patients (51 men, 9 women, mean age 67 years) with the concomitant diagnosis of COPD: main cardiac conditions, presence and reason of BB therapy, type of drug and dosage, main ECG and echocardiographic parameters, medication and data regarding COPD. Besides descriptive statistics, we compared the data of patients with and without BB therapy (chi-square test, level of significance alpha <0.05) in order to identify factors associated with BB usage.

Results: In our study population, 41.6% of the patients had received BB treatment, the most frequently used drug being bisoprolol 2.5 mg and 5 mg q.d. (28%-28%), followed by carvedilol (32%). The prevalence of BB therapy was 51.2% in heart failure patients (48% in NYHA class III and IV, and 66.6% in dilated cardiomyopathy), 38.4% in hypertension, 81.8% in ischemic artery disease, and 64.7% in subjects with atrial fibrillation. The usage of BB therapy was significantly associated with the presence of heart failure (p = 0.047), dilated cardiomyopathy (p = 0.034), ischemic heart disease (p = 0.005), previous myocardial infarction (p = 0.003) and, inversely, with the acute exacerbation of COPD (p = 0.006).

Conclusions: Despite the fact that every cardiac patient with COPD had a potential indication for BB treatment, this was used insufficiently, especially in case of heart failure patients. In daily practice, there is a need for continuous review and improvement of BB usage in these patients.
Double Autologous Stem Cell Transplantation in a Case of Non-secretory Multiple Myeloma
Authors: Lázár Erzsébet , Găzdac Marius , Jakab Szende , Benedek István , Köpeczi Judit-Beáta , Pakucs Annamária , Ács János , Benedek István 
Published: January 2017

Abstract
Multiple myeloma represents a challenge for hematologists because it has become more frequent at a young age in recent years. This is why autologous stem cell transplantation is included in the standard treatment of myeloma patients. We present the case of a 39-year-old patient who was diagnosed with non-secretory myeloma with double autologous transplantation and underwent neurosurgery for spinal cord compression caused by a plasmocytoma at D5 level. We present the evolution and complexity of this very difficult case.
Computed Tomography Biomarkers of Vulnerable Coronary Plaques
Authors: Nyulas Tiberiu , Chiţu Monica , Mester András , Jáni Laura , Condrea Sebastian , Opincariu Diana , Kovács István , Benedek Imre , Benedek Theodora 
Published: January 2017

Abstract
An unstable plaque has a high risk of thrombosis and at the same time for a fast progression of the stenosis degree. Also, “high-risk plaque” and “thrombosis-prone plaque” are used as synonym terms for characterization of a vulnerable plaque. The imaging biomarkers for vulnerable coronary plaques are considered to be spotty calcifications, active remodeling, low-density atheroma and the presence of a ring-like attenuation pattern, also known as the napkin-ring sign. Computed cardiac tomography can determine the plaque composition by assessing the plaque density, which is measured in Hounsfield units (HU). The aim of this manuscript was to provide an update about the most frequently used biomarkers of vulnerability in a vulnerable plaque with the help of computed cardiac tomography.
Incorporating Lean Construction agent into the Building Standards Act: the Spanish case study
Authors: Brioso Xavier , Humero Antonio 
Published: January 2017

Abstract
There is a demand for lean construction in Europe; even though lean construction is still an emerging field and there is growing interest, there are no regulations on this topic. The main objective of this research is to regulate this role when in a project and to define and develop a building agent structure, according to the Building Standards Act (LOE by its acronym in Spanish), to be able to incorporate it into the Spanish law, protecting it from civil liabilities. In Spain, there is jurisprudence in civil jurisdiction based on the LOE to acquit or convict building agents, who are defined in the courts as “constructive managers” or similar. For this reason, courts could establish in the future several liabilities for the lean construction specialist and other agents of the project, depending on their actions and based on the implementation of the lean project delivery system, the target value design and the integrated project delivery. Conversely, it is possible that the level of action of the lean construction specialist may comprise design management, construction management and contract management. Accordingly, one or more building agents should be appropriately incorporated into the LOE according to their functions and responsibilities and based on the levels of action of the lean construction specialist. The creation of the following agents is proposed: design manager, construction manager and contract manager, definitions that are developed in this study. These agents are loosely defined, because any project manager, building information modeling manager or similar may act as one or as more-than-one of them. Finally, the creation of the lean construction manager is also proposed, as the agent who takes on the role of the design manager, construction manager and contract manager, but focused on the lean production principles.
Exploring allene chemistry using phosphorus-based allenes as scaffolds
Authors: Swamy K. C. Kumara , Anitha Mandala , Gangadhararao G. , Rama Suresh R. 
Published: January 2017

Abstract
In this paper, we review some of our results on cycloaddition and cyclization reactions of allenylphosphonates/and allenyl phosphine oxides. Thus nitro-substituted propargylic alcohols react with P(III)–Cl substrates to lead to unprecedented phosphono-benzazepines or -hydroxyindolinones. A similar reaction using a higher stoichiometry of P(III)–Cl precursor has led to the first observation of spontaneous resolution by crystallization in allene chemistry. In the reaction of these phosphorus based allenes with diphenyl isobenzofuran (DPBF), depending on the substituents, both [α, β] and [β, γ]-cycloaddition products are formed. Extension of this work to sulfur based allenes and leading to a new [4+2] cycloadduct with DPBF is reported. A novel cyclization reaction of a functionalized allenylphosphine oxide with diethylamine leading to 3-diethylamino-4-diphenylphosphinoyl-1-naphthol is discovered. Base-catalyzed reactions of allenylphosphonates with 2-substituted benzaldehdes lead to novel thiochromans, chromenes, and quinolines. Allenylphosphonates undergo phosphonylation in the presence of tetrabutyl ammonium fluoride (TBAF). Vinyl azides derived from allenylphosphonates undergo thermolysis to form bis-phosphonopyrazines. [Pd]-catalyzed reactions of allenes with 2-iodophenols, 2-iodobenzyl alcohol and 3-iodo-indole-2-carboxylic acids lead to a variety of benzofurans, benzopyrans and benzopyranones, respectively.
Wild boars (Sus scrofa) as bioindicators of environmental levels of selenium in Poland
Authors: Nowakowska E. , Pilarczyk B. , Pilarczyk R. , Tomza-Marciniak A. , Bąkowska M. , Marciniak A. 
Published: January 2017

Abstract
The objective of the study was to determine selenium content in selected organs (liver, kidney) of wild boars from different regions of Poland. Materials for the study were obtained from 28 sites located in 16 provinces of Poland. Selenium concentrations in organs were determined using spectrofluorometric methods after wet mineralization in HNO3 and HClO4 mixture. Mean selenium concentrations in the investigated wild boars from Poland were 0.230 μg/g wet weight in the liver and 1.327 μg/g w.w. in the kidneys. Hepatic and nephric Se concentrations ranged from 0.036-0.626 μg/g w.w. and 0.322-4.286 μg/g w.w., respectively. Selenium concentrations in the wild boars differed considerably according to geographical location. Concentrations of selenium were highest in wild boars from south-eastern provinces and lowest in animals from northern provinces. Most of Poland’s area is environmentally deficient in this trace element, as evidenced by marginal selenium levels in the organs of the wild boars.
Correlation between peripheral blood cell transcriptomic profile and clinical parameters of chronic mitral valve disease in Dachshunds
Authors: Garncarz M. , Hulanicka M. , Maciejewski H. , Parzeniecka-Jaworska M. , Jank M. 
Published: January 2017

Abstract
Studies identifying specific pathologically expressed genes have been performed on diseased myocardial tissue samples, however less invasive studies on gene expression of peripheral blood mononucleated cells give promising results. This study assessed transcriptomic data that may be used to evaluate Dachshunds with chronic mitral valve disease. Dachshunds with different stages of heart disease were compared to a control, healthy group. Microarray data analysis revealed clusters of patients with similar expression profiles. The clusters were compared to the clinical classification scheme. Unsupervised classification of the studied groups showed three clusters. Clinical and laboratory parameters of patients from the cluster 1 were in accordance with those found in patients without heart disease. Data obtained from patients from the cluster 3 were typical of advanced heart failure patients. Comparison of the cluster 1 and 3 groups revealed 1133 differentially expressed probes, 7 significantly regulated process pathways and 2 significantly regulated Ariadne Metabolic Pathways. This study may serve as a guideline for directing future research on gene expression in chronic mitral valve disease.
Comparison between cryoablation and irreversible electroporation of rabbit livers at a location close to the gallbladder
Authors: Zeng Jianying , Qin Zilin , Zhou Liang , Fang Gang , Chen Jibing , Li Jialiang , Niu Lizhi , Liang Bing , Xu Kecheng 
Published: January 2017

Abstract

Background
The ablation of liver tumors located close to the gallbladder is likely to lead to complications. The aim of this article is to compare the safety and efficacy of irreversible electroporation (IRE) and cryoablation in rabbit livers at a location close to the gallbladder.

Materials and methods
We performed cryoablation (n = 12) and IRE (n = 12) of the area of the liver close to the gallbladder in 24 New Zealand white rabbits in order to ensure gallbladder damage. Serum aminotransferase and serum bilirubin levels were measured before and after the ablation. Histopathological examination of the ablation zones in the liver and gallbladder was performed on the 7th day after the ablation.

Result
Seven days after the ablation, all 24 animals were alive. Gallbladder perforation did not occur in the IRE group; only mucosal epithelial necrosis and serous layer edema were found in this group. Gallbladder perforation occurred in four rabbits in the cryoablation group. Serum aminotransferase and serum bilirubin levels obviously increased in both groups by Day 3 and decreased gradually thereafter. The elevation in aminotransferase and bilirubin levels was greater in the cryoablation group than the IRE group. Pathological examination revealed complete necrosis of the liver parenchyma from the ablation center to the gallbladder in both groups, but bile duct and granulation tissue hyperplasia were observed in only the IRE group. Full-thickness gallbladder-wall necrosis was seen in the cryoablation group.

Conclusions
For ablation of the liver area near the gallbladder, IRE is superior to cryoablation, both in terms of safety (no gallbladder perforation in the IRE group) and efficacy (complete necrosis and rapid recovery in the IRE group).
Carotid artery stiffness, digital endothelial function, and coronary calcium in patients with essential thrombocytosis, free of overt atherosclerotic disease
Authors: Vrtovec Matjaz , Anzic Ajda , Zupan Irena Preloznik , Zaletel Katja , Blinc Ales 
Published: January 2017

Abstract

Background
Patients with myeloproliferative neoplasms (MPNs) are at increased risk for atherothrombotic events. Our aim was to determine if patients with essential thrombocytosis (ET), a subtype of MPNs, free of symptomatic atherosclerosis, have greater carotid artery stiffness, worse endothelial function, greater coronary calcium and carotid plaque burden than control subjects.

Patients and methods
40 ET patients without overt vascular disease, and 42 apparently healthy, age and sex-matched control subjects with comparable classical risk factors for atherosclerosis and Framingham risk of coronary disease were enrolled. All subjects were examined by physical and laboratory testing, carotid echo-tracking ultrasound, digital EndoPat pletysmography and CT coronary calcium scoring.

Results
No significant differences were found between ET patients and controls in carotid plaque score [1 (0-1.25) vs. 0 (0-2), p=0.30], β- index of carotid stiffness [7.75 (2.33) vs. 8.44 (2,81), p=0.23], pulse wave velocity [6,21 (1,00) vs. 6.45 (1.04) m/s; p=0.46], digital reactive hyperemia index [2.10 (0.57) vs. 2.35 (0.62), p=0.07], or augmentation index [19 (3-30) vs. 13 (5-22) %, p=0.38]. Overall coronary calcium burden did not differ between groups [Agatston score 0.1 (0-16.85) vs. 0 (0-8.55), p=0.26]. However, significantly more ET patients had an elevated coronary calcium score of >160 [6/40 vs. 0/42, p < 0.01].

Conclusions
No significant differences between groups were found in carotid artery morphology and function, digital endothelial function or overall coronary calcium score. Significantly more ET patients had an elevated coronary calcium score of >160, indicating high cardiovascular risk, not predicted by the Framingham equation.
Stories as Silt in Graham Swift’s Waterland
Authors: Catană Elisabeta Simona 
Published: January 2017

Abstract
The essay analyses Graham Swift’s Waterland and shows that history and identity are subject to a process of reconstruction within stories which evince their author’s power to build on the past based on his vision and cultural experience. We associate the process of recreating the world of the past through stories with the process of recreating a new world through siltation. The same as silt develops land and a new world on the already existing pieces of land reclaimed from water, stories reconstruct history and the past. Both silt and stories reconstruct the past.
In Search of the Invisible Roots: Immigrant Experiences in Jhumpa Lahiri’s Unaccustomed Earth
Authors: Rogobete Daniela 
Published: January 2017

Abstract
This paper attempts an analysis of the metaphorical strategies Jhumpa Lahiri uses in her 2008 collection of short stories Unaccustomed Earth in order to explore and comment on the intricate relations and the complex web of feelings and resentments, longing and attachment that make up the essence of family life as shaped by the diasporic experience. In this volume, Lahiri particularly focuses on the conflicting emotions engendered by migration, on the articulation of displacement and reintegration, and on the capacity to fully assume the diasporic experience and turn it into a meaningful assertion of one’s identity.
Trial-by-Trial Motor Cortical Correlates of a Rapidly Adapting Visuomotor Internal Model
Authors: Stavisky Sergey D. , Kao Jonathan C. , Ryu Stephen I. , Shenoy Krishna V. 
Published: January 2017

Accurate motor control is mediated by internal models of how neural activity generates movement. We examined neural correlates of an adapting internal model of visuomotor gain in motor cortex while two macaques performed a reaching task in which the gain scaling between the hand and a presented cursor was varied. Previous studies of cortical changes during visuomotor adaptation focused on preparatory and perimovement epochs and analyzed trial-averaged neural data. Here, we recorded simultaneous neural population activity using multielectrode arrays and focused our analysis on neural differences in the period before the target appeared. We found that we could estimate the monkey's internal model of the gain using the neural population state during this pretarget epoch. This neural correlate depended on the gain experienced during recent trials and it predicted the speed of the subsequent reach. To explore the utility of this internal model estimate for brain–machine interfaces, we performed an offline analysis showing that it can be used to compensate for upcoming reach extent errors. Together, these results demonstrate that pretarget neural activity in motor cortex reflects the monkey's internal model of visuomotor gain on single trials and can potentially be used to improve neural prostheses.SIGNIFICANCE STATEMENTWhen generating movement commands, the brain is believed to use internal models of the relationship between neural activity and the body's movement. Visuomotor adaptation tasks have revealed neural correlates of these computations in multiple brain areas during movement preparation and execution. Here, we describe motor cortical changes in a visuomotor gain change task even before a specific movement is cued. We were able to estimate the gain internal model from these pretarget neural correlates and relate it to single-trial behavior. This is an important step toward understanding the sensorimotor system's algorithms for updating its internal models after specific movements and errors. Furthermore, the ability to estimate the internal model before movement could improve motor neural prostheses being developed for people with paralysis.
A Delay between Motor Cortex Lesions and Neuronal Transplantation Enhances Graft Integration and Improves Repair and Recovery
Authors: Péron Sophie , Droguerre Marine , Debarbieux Franck , Ballout Nissrine , Benoit-Marand Marianne , Francheteau Maureen , Brot Sébastien , Rougon Geneviève , Jaber Mohamed , Gaillard Afsaneh 
Published: January 2017

We previously reported that embryonic motor cortical neurons transplanted immediately after lesions in the adult mouse motor cortex restored damaged motor cortical pathways. A critical barrier hindering the application of transplantation strategies for a wide range of traumatic injuries is the determination of a suitable time window for therapeutic intervention. Here, we report that a 1 week delay between the lesion and transplantation significantly enhances graft vascularization, survival, and proliferation of grafted cells. More importantly, the delay dramatically increases the density of projections developed by grafted neurons and improves functional repair and recovery as assessed by intravital dynamic imaging and behavioral tests. These findings open new avenues in cell transplantation strategies as they indicate successful brain repair may occur following delayed transplantation.SIGNIFICANCE STATEMENTCell transplantation represents a promising therapy for cortical trauma. We previously reported that embryonic motor cortical neurons transplanted immediately after lesions in the adult mouse motor cortex restored damaged cortical pathways. A critical barrier hindering the application of transplantation strategies for a wide range of traumatic injuries is the determination of a suitable time window for therapeutic intervention. We demonstrate that a 1 week delay between the lesion and transplantation significantly enhances graft vascularization, survival, proliferation, and the density of the projections developed by grafted neurons. More importantly, the delay has a beneficial impact on functional repair and recovery. These results impact the effectiveness of transplantation strategies in a wide range of traumatic injuries for which therapeutic intervention is not immediately feasible.
The Phenotypic Plasticity of Duplicated Genes inSaccharomyces cerevisiaeand the Origin of Adaptations
Authors: Mattenberger Florian , Sabater-Muñoz Beatriz , Toft Christina , Fares Mario A 
Published: January 2017

AbstractGene and genome duplication are the major sources of biological innovations in plants and animals. Functional and transcriptional divergence between the copies after gene duplication has been considered the main driver of innovations . However, here we show that increased phenotypic plasticity after duplication plays a more major role than thought before in the origin of adaptations. We perform an exhaustive analysis of the transcriptional alterations of duplicated genes in the unicellular eukaryote Saccharomyces cerevisiae when challenged with five different environmental stresses. Analysis of the transcriptomes of yeast shows that gene duplication increases the transcriptional response to environmental changes, with duplicated genes exhibiting signatures of adaptive transcriptional patterns in response to stress. The mechanism of duplication matters, with whole-genome duplicates being more transcriptionally altered than small-scale duplicates. The predominant transcriptional pattern follows the classic theory of evolution by gene duplication; with one gene copy remaining unaltered under stress, while its sister copy presents large transcriptional plasticity and a prominent role in adaptation. Moreover, we find additional transcriptional profiles that are suggestive of neo- and subfunctionalization of duplicate gene copies. These patterns are strongly correlated with the functional dependencies and sequence divergence profiles of gene copies. We show that, unlike singletons, duplicates respond more specifically to stress, supporting the role of natural selection in the transcriptional plasticity of duplicates. Our results reveal the underlying transcriptional complexity of duplicated genes and its role in the origin of adaptations.