bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toxic Metals and Metalloids in Food: Current Status, Health Risks, and Mitigation Strategies
Authors: Zhao Di , Wang Peng , Zhao Fang-Jie 
Published: October 2024

Abstract
Purpose of Review
Exposure to toxic metals/metalloids, such as arsenic (As), cadmium (Cd), and lead (Pb), through food consumption is a global public health concern. This review examines the contamination status of these metals/metalloids in food, assesses dietary intake across different populations, and proposes strategies to reduce metal/metalloid exposures throughout the food chain.

Recent Findings
For the general population, dietary intake of metals/metalloids is generally lower than health-based guidance values. However, for vulnerable populations, such as infants, children, and pregnant women, their dietary intake levels are close to or even higher than the guidance values. Among different food categories, seafood shows higher total As, but largely present as organic species. Rice accumulates higher As concentration than other cereals, with inorganic As (iAs) and dimethylarsinic acid (DMA) being the main As species. Methylated thioarsenate species, such as dimethylmonothioarsenate, have also been detected in rice. The distribution of iAs and DMA in rice shows geographical variation. Additionally, seafood and cocoa products generally contain more Cd than other food, but seafood consumption does not significantly increase in adverse health effects due to its high zinc and iron content. Compared to As and Cd, Pb concentrations in food are generally lower. To minimize the health risks of metal/metalloid exposure, several strategies are proposed.

Summary
Food contamination with toxic metals/metalloids poses significant concerns for human health, particularly for vulnerable populations. This review provides scientific evidence and suggestions for policy makers to reduce human exposure of metals/metalloids via dietary intake.
Measurement of PDE5 concentration in human serum: proof-of-concept and validation of methodology in control and prostate cancer patients
Authors: Gravina Giovanni Luca , Guida Eugenia , Dri Maria , Massoud Renato , Di Stasi Savino M. , Fucci Giorgio , Sansone Andrea , Dolci Susanna , Jannini Emmanuele A. 
Published: October 2024

Abstract

Purpose
We aimed to investigate if the type 5 phosphodiesterase (PDE5), an enzyme with cardinal biological functions in sexual and cardiovascular health, can be detected and quantited in human serum.

Methods
Blood samples were collected from control male and female subjects. PDE5 levels were measured by a specific ELISA kit. ROC curves weighted for age and serum levels of PSA (male subjects), or age (female subjects) were used to identify the predictive ability in the detection of PCa. Sensitivity, specificity, PPV and NPV values were determined for cut-off value determined during ROC curve analysis.

Results
41 control male subjects, 18 control female subjects, and 55 consecutive subjects, of which 25 were affected by benign prostatic hypertrophy (BPH) and 30 with histologically confirmed prostate cancer (PCa), were studied. PDE5 serum levels were detectable in all subjects (range: 5 to 65 ng/ml). Analysis by MANCOVA identified a significant difference in serum PDE5 between control subjects or hyperplasia patients and PCa patients. Marginal means of serum PDE5 concentrations showed a significant difference (p < 0.001). The ROC curve demonstrated that PDE5 serum levels can predict men with or without PCa, with 0.806 AUC value (p < 0.0001). Using a 12.705 ng/ml PDE5 serum cut-off yielded sensitivity, specificity, PPV, and NPV of 83.3%, 77.27%, 62.5%, and 91.1% in detecting men with histologically proven PCa, respectively.

Conclusions
We demonstrated, for the first time, that PDE5 levels can be detected in human sera and that PCa patients have significantly higher PDE5 concentration compared to BPH patients or male and female controls. While serum PDE5 level measurement may open new research avenues, the clinical relevance of PDE5 levels in PCa patients deserves further investigation.
Unusual infections and thrombotic events in Cushing’s syndrome
Authors: Barbot Mattia , Lazzara Martina , Mazzeo Pierluigi , Pecori Giraldi Francesca 
Published: October 2024

AbstractThe diagnosis of Cushing’s syndrome requires a high degree of suspicion, especially in patients in whom typical features are overshadowed by other ailments. These include, among others, widespread opportunistic infections or sepsis and venous or arterial thromboembolism.This Review will summarize available data on patients presenting with severe infections or thrombotic events and the best approach to diagnosis.
Who and how to screen for endogenous hypercortisolism in type 2 diabetes mellitus or obesity
Authors: Guarnotta Valentina , Giordano Carla , Reimondo Giuseppe 
Published: October 2024

Abstract
Purpose
The current review aims to summarize and discuss the prevalence of confirmed hypercortisolism in patients with diabetes mellitus or obesity, analysing the screening tests used and their accuracy, in order to better identify whether patients with diabetes mellitus and obesity should be screened for Cushing’s syndrome (CS) and how.

Methods
A narrative review was performed including publications focusing on the current knowledge on prevalence of confirmed hypercortisolism in patients with type 2 diabetes mellitus (T2DM) or obesity and on screening tests used to detect CS.

Results
The studies reviewed suggest that the prevalence of CS in patients with T2DM is variable, ranging from 0.6 to 9.3%. The most used screening test is the overnight cortisol after 1 mg of dexamethasone suppression test (DST), with a false positive rate ranging from 3.7 to 21%. The prevalence of CS among obese patients is generally about 1%, except for two studies which reported higher prevalence. For obese patients, 1 mg DST and late-night salivary cortisol are the most accurate screening tests for CS.

Conclusions
Clinical expertise remains the mainstay to identify which subjects should be screened for CS. The evaluation of the clinical stigmata of CS and the combination with clinical comorbidities typical of CS are the stronger predictors of CS. In addition, we could hypothesize that in patients with T2DM, overnight 1 mg DST is the more accurate screening test for CS. By contrast, in patients with obesity both LNSC and overnight 1 mg DST could be equally used for the screening of hypercortisolism.
Shear mechanical behavior and fracturing path of red sandstone treated by joninted effect of water-fractures
Authors: Li Yangyang , Zhu Huicong , Zhang Shichuan , Chen Bing , Zhang Buchu 
Published: October 2024

AbstractWater content and primary fractures can change the mechanical characteristics of rock, making it easy to induce geological disasters. Therefore, direct shear tests of red sandstone under the action of water-fracture were carried out in this paper. The results show that shear strength of rock samples with fractures is less than that of intact rock samples. With the increase of primary fracture dip angle, shear strength and macroscopic crushing area of the rock sample increases first and then decreases with 20° as the boundary. It shows that the primary fractures weaken the shear mechanical properties and change the macroscopic failure mode. The shear performance of water-bearing rock samples is weaker than that of intact rock samples, and the weakening degree of water-saturated on shear performance of rock samples is lower than that of unsaturated water state. The fracture surfaces of rock samples are divided into 'shortest path single through type', 'longest path single through type' and 'cross path through type'. The failured rock samples are divided into 'single through type' and 'cross through type'. The research results can provide reference for geological disaster management under relevant conditions.
Classroom Interactions Facilitate a Sense of Belonging in Remote STEM Classes: Lessons from a Large-Scale Quantitative Study
Authors: Narla Avaneesh V. , Edwards Madison M. , Bullard Elizabeth , Petrie Katherine L. , Heinrichsen Erilynn T. 
Published: October 2024

AbstractDuring the global COVID-19 pandemic, instructors strove to facilitate student learning, engagement, and community in an unfamiliar environment, while students adapted to a college experience that differed from their expectations. This context provided the opportunity to identify factors that increased undergraduates’ sense of belonging in remote STEM classrooms. We analyzed responses from 1589 students in 26 undergraduate STEM courses at a large R1 research university in Likert-style surveys to assess how the remote modality affected their sense of belonging in their STEM course. Likewise, we analyzed data from 22 instructors about their pedagogical mindset and implementation of classroom activities. K-means clustering of student survey responses sorted classes into four significantly distinct clusters. Student responses in cluster 1 revealed an increased sense of belonging in the post-survey, whereas students in cluster 4 reported a decreased sense of belonging. Further, we observed that a higher frequency of active learning activities (student–student and student-instructor interactions) and instructor type (teaching faculty) correlated with an increased sense of belonging. Many studies have investigated alterations in students’ sense of belonging; our study contributes by identifying activities that enhance a sense of belonging in remote STEM classrooms. Moreover, our findings from a quantitative study allow us to propose ways instructors can modify their courses to increase student sense of belonging and insulate students from the isolation of remote classrooms.
Morita invariance of unbounded bivariant K-theory
Authors: Kaad Jens 
Published: October 2024

Abstract
We introduce a notion of Morita equivalence for non-selfadjoint operator algebras equipped with a completely isometric involution (operator

$$*$$

∗

-algebras). We then show that the unbounded Kasparov product by a Morita equivalence bimodule induces an isomorphism between equivalence classes of twisted spectral triples over Morita equivalent operator

$$*$$

∗

-algebras. This leads to a tentative definition of unbounded bivariant K-theory and we prove that this bivariant theory is related to Kasparov’s bivariant K-theory via the Baaj-Julg bounded transform. Moreover, the unbounded Kasparov product provides a refinement of the usual interior Kasparov product. We illustrate our results by proving

$$C^1$$

C
1

-versions of well-known

$$C^*$$

C
∗

-algebraic Morita equivalences in the context of hereditary subalgebras, conformal equivalences and crossed products by discrete groups.
Large-scale energy storage for carbon neutrality: thermal energy storage for electrical vehicles
Authors: Zhao Weiwei , Lin Xuefeng , Zhang Tongtong , Ding Yulong 
Published: October 2024

AbstractThermal Energy Storage (TES) systems are pivotal in advancing net-zero energy transitions, particularly in the energy sector, which is a major contributor to climate change due to carbon emissions. In electrical vehicles (EVs), TES systems enhance battery performance and regulate cabin temperatures, thus improving energy efficiency and extending vehicle range. The enhanced efficiency reduces overall energy consumption in EVs. Consequently, this reduction in energy demand can lead to decreased infrastructure needs, minimising the scale and investment required in energy production and distribution systems. Furthermore, the integration of TES with existing infrastructure allows for the simultaneous charging of thermal and electrical energy, leveraging waste heat or renewable energy sources. This not only cuts costs by optimizing resource use but also bolsters sustainability by minimising reliance on non-renewable energy sources. The widespread adoption of TES in EVs could transform these vehicles into nodes within large-scale, distributed energy storage systems, thus supporting smart grid operations and enhancing energy security. Strategic investments and regulatory updates are essential to realise a sustainable, carbon-neutral transportation future, underpinned by robust, cost-efficient infrastructure.
The Death of “Jewish Christianity” in the Afterlife of the Clementine Recognitions
Authors: Campbell Warren 
Published: October 2024

AbstractThe editorial history of the two Pseudo-Clementine narratives known as the Recognitions and the Homilies is intricate, to say the least. From an ever-elusive “basic writing” spring two novelistic stories with extensive translation histories, subjected to significant editorial interventions, and anthologized alongside other late ancient and medieval texts. This article focuses on the addition of pseudonymous epistles as prefatory material for these Pseudo-Clementines and follows one of these letters in particular, the Epistula Clementis (Ep. Clem.). The Epistula Clementis accompanies the Latin Pseudo-Clementine Recognitions in a host of medieval anthologies concerned with Petrine hagiography and ecclesial succession, as well as histories, dialogues, and epistolary texts with anti-Judaic resonances. I argue that the Epistula Clementis, as a prefatory text, was integral to the success of the Recognitions in these later anthologies, highlighting the transformative power of the preface upon its associated text as well as the hermeneutical force of the anthology itself.
Franz Rosenzweig’s Account of Revelation in Light of Its Protestant Background
Authors: Herskowitz Daniel M. 
Published: October 2024

AbstractIn the subsection “Grammar of Eros (The Language of Love)” in section 2 of book 2 of The Star of Redemption, the beating heart of the work, Franz Rosenzweig offers a peculiar portrait of the event of revelation. What is presented is a dramatization of the encounter between the loving God and the beloved human soul, a developing scene consisting of a series of utterances and experiences, many of which appear unwarranted. Why does Rosenzweig present revelation in this manner? This article seeks to explain the seemingly arbitrary twists and turns in the dramatized “plot” through which Rosenzweig depicts revelation by demonstrating that it follows in its main features the prevalent Protestant understanding of revelation as encompassing not only divine self-disclosure but also the discovery of sin, confession, forgiveness of sin, reconciliation, attainment of selfhood, and redemption, and is framed according to the directives of the Lutheran foundational principle of “at once a sinner and justified (Simul Justus et Peccator). In so doing, it exhibits Rosenzweig’s deep embeddedness in the Protestant theological discourse of his time and shows that The Star should be understood in light of the contemporary Protestant theology.
God’s Body and the Material Turn: Divine (Im)Materiality in Biblical Theophanies
Authors: Wilson Brittany E. 
Published: October 2024

AbstractAlthough biblical scholars are increasingly turning their attention to the question of God’s body, few clarify how precisely this “body” complicates the long-held claim that God is immaterial. The present article addresses this oversight by attending to the ways in which biblical accounts of God’s body intersect with wider tradents of thought on materiality and immateriality, including, above all, the recent cross-disciplinary “turn” known as new materialism. The article begins by discussing what biblical scholars mean when they say “God’s body” and how biblical theophanies in particular complicate the belief that God is immaterial. It then discusses new materialism and how key emphases in this scholarly shift similarly complicate the belief in God’s immateriality. Third and finally, the article returns to biblical theophanies by reading these accounts through a new materialist lens, focusing in particular on God’s manifestations in material, nonhuman forms. In the end, I suggest not only that biblical theophanies problematize traditional ways of conceiving God within the history of biblical interpretation but also that new materialism can better enable us to see how these accounts portray the relationship between God and embodied materialities.
New Temporalities and a Temporal (Re)Turn in New Testament Studies? The Cullmann/Bultmann Debate Revisited
Authors: Edsall Benjamin A. 
Published: October 2024

AbstractIn light of a recent surge of interest in time across a range of disciplines, a case has been made that New Testament studies has experienced a “temporal turn.” This claim raises an important question about how one understands the relation of recent developments to earlier, long-held debates about time among New Testament scholars. This question is answered here by revisiting the “salvation history” debate between Oscar Cullmann and Rudolf Bultmann, with the help of Paul Ricoeur’s analysis in Time and Narrative and in the context of recent trends in work on “temporalities.” This article argues that, although in many respects recent work on time offers fresh language to describe the kinds of time at stake for New Testament scholarship, it is also true that attending to the earlier debates shows how parts of the temporal turn are in fact a return to questions long considered.
What is the usual eating window for children and adolescents aged 6-20 years: a systematic review
Authors: Townley J. , Northstone K. , Hinton E.C. , Hamilton-Shield J.P. , Searle A.J. , Leary S.D 
Published: October 2024

This abstract was awarded the Student Competition prize.Time-limited eating is a dietary intervention whereby calorie intake is limited to a specific window of time during the day(1). The usual eating windows (EW) of adults, and how this can be manipulated for dietary interventions, is well documented(2). However, there is a paucity of data on the usual EW of children and adolescents, which may be a useful intervention for reducing obesity.The primary objective was to systematically review existing literature on the usual EW of children and adolescents. Secondary objectives were to identify average clock times of first and last food/drink intakes and also variations in EW and clock times by age, nationality or weight status subgroups, if available data allowed.Two databases (Medline and Embase) were searched for eligible papers published between February 2013 and February 2023. Included papers were forward searched using the citation network on Web of Science. 6347 papers were identified, and after deduplication 4569 papers were screened by two independent reviewers. Methodological quality was assessed using a Joanna Briggs Institute checklist(3).Ten studies were included, with both observational and experimental designs. These studies had a total population of 4,589 participants, with individual study sample sizes ranging from 22 to 2195. Ages of participants ranged from 6 – 20 years, with six studies involving adolescents alone (≥10 years), and four involving children and adolescents. There were four studies from the USA, two from Germany and one each from Brazil, India, The Netherlands and pan-European.Narrative synthesis showed large variations in average eating windows from 9.7 to 16.4 hours. Only four studies included clock times of intake, with large variations in both first and last intake times. Five studies were included in a random-effects meta-analysis, in which heterogeneity was considerable (I2 = 95.8%), and pooled duration of usual daily eating was 11.3 hours (95% confidence interval (CI) 10.95, 11.73). Sources of heterogeneity included differences in study design and populations, variation in dietary assessments methods and definition of eating windows. Narrative synthesis of an adolescent sub-group showed eating windows increased as children got older. Four studies were included in a random-effects sub-group meta-analysis, with a pooled EW of 11.2 hours (95% CI 10.27, 12.05; I2 = 96.6%) in adolescents. Insufficient data prevented further subgroup analysis.In conclusion large variations in eating windows exist across different study populations, with limited data available on first and last intake times; however, the pooled data suggest it may be possible to design time-limited eating interventions in paediatric populations aimed at reducing eating windows. Further high-quality research, of eating windows and associations with health outcomes, is needed.
Assessment of motivating factors to follow a time-restricted eating dietary protocol
Authors: Lages M. , Carmo-Silva S. , Barros R. , Guarino M.P. 
Published: October 2024

The number of clinical studies assessing the effects of time-restricted eating (TRE) has increased in recent years(1). The results of the studies conducted on humans demonstrate some health benefits, however, there is still a need to design larger and longer randomized clinical trials to prove the effectiveness and long-term benefits of these types of interventions(2). However, to ensure these health benefits, individuals need to be able to integrate its principles into their daily routines. This work aimed to associate daily habits with the potential adherence to different TRE protocols and to determine the factors that predict adherence to these protocols.A cross-sectional study was conducted using an online questionnaire based on a previous study(3), to assess the dietary and sleeping habits, daily routines and willingness to adhere to different windows of time-restricted eating in a sample of Portuguese adults. To analyze the associations between variables, the Spearman correlation coefficient and the Chi-Square test were calculated, and multiple linear regression was performed to identify the predictive factors. Statistical analysis was conducted on IBM SPSS Statistics version 29.0.130 responses were obtained (26% men, 74% women) with a mean age of 37.9±13.59 years old. On workdays, 60.0% of participants reported a daily eating window (the period between the first and last caloric intake) of 12h-14h, while on free days the highest percentage (41.5%) was between 10h12h. An inverse correlation was observed between age and willingness to adhere to a TRE protocol if there were health benefits (r=-0.356, p<0.001). Moderate correlations were also found between the availability to follow a TRE protocol on work days (r=0.538) and free days (r=0.598) and the potential health benefits of this type of intervention (p<0.001)). Associations were found between sex and potential adherence to the TRE protocol (χ2=10.644, df=2, p=0.005), with a tendency for more men not to adhere to a TRE protocol. There was also an association between body weight management and reducing the eating window by 1h-2h (χ² =24.883, df=12, p=0.015) and 2h-3h (χ²=22.367, df=12, p=0.034). The living situation, motivation for change, income, weight management, cooking knowledge, and working schedule were among the main factors predicting the willingness to adhere to TRE protocols (p<0.05).People’s willingness and motivation to adhere to TRE protocols outside the controlled environment of a clinical study depends on several factors. The results presented herein provide information that may be central when considering the translation of study results into nutritional practice and counselling.