bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: 8‐O‐4′ Neolignan Glycosides from the Aerial Parts of Matteuccia struthiopteris.
Authors: Zhu Ling‐Juan , Yan Fei , Chen Jin‐Peng , Zhang Nan , Zhang Xue , Yao Xin‐Sheng 
Published: May 2016

Abstractisolation, structural elucidation, and anti‐influenza A (H1N1) activity of matteustruthiosides A (I) and B (II)
ChemInform Abstract: Structure of Amyloid Oligomers and Their Mechanisms of Toxicities: Targeting Amyloid Oligomers Using Novel Therapeutic Approaches
Authors: Salahuddin Parveen , Fatima Munazza Tamkeen , Abdelhameed Ali Saber , Nusrat Saima , Khan Rizwan Hasan 
Published: May 2016

AbstractReview: 264 refs.
ChemInform Abstract: Graphitic Carbon Nitride “Reloaded” Emerging Applications Beyond (Photo)Catalysis
Authors: Liu Jian , Wang Hongqiang , Antonietti Markus 
Published: May 2016

AbstractReview: renaissance of graphitic carbon nitride (g‐C3N4) as a highly active photo/electrocatalyst, and diverse applications of the metal‐free polymer; 94 refs.
Hydroprocessing of 4‐methylanisole as a representative of lignin‐derived bio‐oils catalyzed by sulphided CoMo/γ‐Al2O3: A semi‐quantitative reaction network
Authors: Saidi Majid , Rahimpour Hamid Reza , Rahzani Behnam , Rostami Parisa , Gates Bruce C. , Rahimpour Mohammad Reza 
Published: May 2016

AbstractCatalytic hydroprocessing of 4‐methylanisole as a representative of lignin‐derived bio‐oils was catalyzed by a commercial sulphided CoMo/γ‐Al2O3 catalyst in a fixed‐bed flow reactor at various space velocities, temperatures, pressures, and feed compositions. An approximate reaction network is presented that accounts for the major products, and approximate kinetics are also presented. The kinetically significant reactions are 4‐methylanisole conversion to (a) 4‐methylphenol via hydrogenolysis, (b) toluene and benzene via hydrodeoxygenation, (c) cyclohexanone and methylcyclohexanone via hydrogenation, and (d) methylphenol derivatives via alkylation and transalkylation. The formation of toluene and benzene along with water and methanol from 4‐methylanisole is inferred to result from direct scission of the Caromatic–O bond. Cleavage of the Cmethyl–O bond is faster than cleavage of the Caromatic–O bond. The main pathway to toluene formation is the hydrogenolysis of the Caromatic–O bond of the intermediate 4‐methylphenol.
Use of stereotactic body radiotherapy for prostate cancer in the United States from 2004 through 2012
Authors: Baker Brock R. , Basak Ramsankar , Mohiuddin Jahan J. , Chen Ronald C. 
Published: May 2016

BACKGROUNDStereotactic body radiotherapy (SBRT) is a newer treatment option for patients with localized prostate cancer. The rates of diffusion of this technology across the United States are unknown. The goal of the current study was to describe the use of SBRT among patients with prostate cancer based on different risk groups (low, intermediate, or high risk) and by type of facility (community cancer program, comprehensive community cancer program, or academic program) in which patients were treated.METHODSUsing the National Cancer Data Base, a national registry that contains approximately 70% of patients with cancer in the United States, the authors identified 274,466 men between the ages of 40 to 80 years who were diagnosed from 2004 to 2012 with localized prostate cancer and received radiation therapy (RT) as their initial treatment. The authors described the prevalence of SBRT use each year, and multivariable analysis was used to examine factors associated with the receipt of SBRT.RESULTSIn 2004, SBRT use was low (<1% in all patient groups), and was observed to increase steadily each year. By 2012, 8.8% of low‐risk patients treated at academic centers with RT received SBRT. Uptake of SBRT was highest in patients with low‐risk or intermediate‐risk disease. Multivariable analysis demonstrated that year of diagnosis, type of center, risk group, and race were all significantly associated with the use of SBRT.CONCLUSIONSTo the authors' knowledge, the current study is the first report of the adoption of SBRT for localized prostate cancer across the United States. Diffusion was noted to be slowest at community cancer programs, reflecting potential barriers of cost or expertise for this new technology. Adoption of SBRT was found to be highest among patients with low‐risk or intermediate‐risk disease, in accordance with the bulk of patients included in published SBRT studies. Cancer 2016;122:2234–41. © 2016 American Cancer Society.
Phase 2 study of intensified chemotherapy and allogeneic hematopoietic stem cell transplantation for older patients with acute lymphoblastic leukemia
Authors: Fathi Amir T. , DeAngelo Daniel J. , Stevenson Kristen E. , Kolitz Jonathan E. , Asch Julie D. , Amrein Philip C. , Attar Eyal C. , Steensma David P. , Wadleigh Martha , Foster Julia , Connolly Christine , Galinsky Ilene , Devoe Craig E. , Stone Richard M. , Neuberg Donna S. , Ballen Karen K. 
Published: May 2016

BACKGROUNDOutcomes among older patients with acute lymphoblastic leukemia remain poor. This study sought to determine the efficacy of an intensified, multi‐agent approach derived from a Dana‐Farber consortium trial in younger adults for patients older than 50 years (trial identifier NCT00973752).METHODSThe primary endpoint was overall survival (OS) at 1 year. Patients received induction chemotherapy with vincristine, prednisone, doxorubicin, and pegylated asparaginase. Imatinib was incorporated for Philadelphia chromosome–positive disease. After induction, the first consolidation incorporated clofarabine. Patients in remission could proceed to allogeneic hematopoietic cell transplantation (HCT) after induction and consolidation I. Those not receiving HCT went on to receive central nervous system, consolidation II, and continuation phases of treatment.RESULTSThirty patients were enrolled: 19 achieved a complete remission (CR) after induction and 1 achieved CR after consolidation I for a CR rate of 67%. Sixteen patients underwent HCT. The proportion surviving at 1 year was 63%, and this met the primary endpoint. The 2‐year OS rate was 52% (n = 30), and the 2‐year disease‐free survival rate was 52% for patients achieving CR (n = 20). There was no survival advantage among those undergoing HCT. Therapy‐related hyperbilirubinemia prompted adjustments and limitations to asparaginase dosing.CONCLUSIONSIntensified chemotherapy can result in improved outcomes in comparison with historical data. Additional studies of similarly intensive regimens are warranted in this population. Cancer 2016;122:2379–2388. © 2016 American Cancer Society.
A computational framework to characterize and compare the geometry of coronary networks
Authors: Bulant C. A. , Blanco P. J. , Lima T. P. , Assunção  A.N. , Liberato G. , Parga J. R. , Ávila L. F. R. , Pereira A. C. , Feijóo R. A. , Lemos P. A. 
Published: May 2016

SummaryThis work presents a computational framework to perform a systematic and comprehensive assessment of the morphometry of coronary arteries from in vivo medical images. The methodology embraces image segmentation, arterial vessel representation, characterization and comparison, data storage, and finally analysis. Validation is performed using a sample of 48 patients. Data mining of morphometric information of several coronary arteries is presented. Results agree to medical reports in terms of basic geometric and anatomical variables. Concerning geometric descriptors, inter‐artery and intra‐artery correlations are studied. Data reported here can be useful for the construction and setup of blood flow models of the coronary circulation. Finally, as an application example, similarity criterion to assess vasculature likelihood based on geometric features is presented and used to test geometric similarity among sibling patients. Results indicate that likelihood, measured through geometric descriptors, is stronger between siblings compared with non‐relative patients. Copyright © 2016 John Wiley & Sons, Ltd.
Modeling and simulation of global and sleep states in ACPI‐compliant energy‐efficient cloud environments
Authors: Xavier Miguel G. , Rossi Fábio D. , De Rose César A. F. , Calheiros Rodrigo N. , Gomes Danielo G. 
Published: May 2016

SummaryThe more large‐scale data centers infrastructure costs increase, the more simulation‐based evaluations are needed to understand better the trade‐off between energy and performance and support the development of new energy‐aware resource allocation policies. Specifically, in the cloud computing field, various simulators are able to predict and measure the behavior of applications on different architectures using different resource allocation policies. Yet, only a few of them have the ability to simulate energy‐saving strategies, and none of them support the complete advanced configuration and power interface (ACPI) specification. ACPI defines a terminology for all possible power states of a machine and their associated power rate. The hardware industry has relied on ACPI to provide up‐to‐date standard interfaces for hardware discovery, configuration, power management, and monitoring, enabling a better understanding of the energy consumption level of different hardware states, referred to as ACPI G‐states, S‐states, and P‐states. In this paper, we improve the modeling and simulation of the ACPI G/S‐states and show not only that these states offer different energy‐saving levels but also that state transitions consume energy. In addition, we model the latency to transit between two states and the effects on the turnaround time when the transitions are not performed conservatively. Furthermore, the equations provide essential information to quantify the trade‐off between energy consumption and performance and assist in the analysis/decision on which strategy fits better in the environment and how it could be refined. Our expanded energy model was implemented in CloudSim and validated with simulation‐based experiments with a very high level of accuracy, with a standard deviation of at most 6%. Copyright © 2016 John Wiley & Sons, Ltd.
Randomized trial of the efficacy and safety of a new oral spray for drug‐induced xerostomia
Authors: Donath Frank , Tonner Françoise , Chavda Rajeev , Gatignol Jean‐Philippe , Bouyrie Julie 
Published: May 2016

AbstractThe aim of this study was to evaluate the efficacy, safety, and tolerability of three formulations of DC161 oral spray, a saliva substitute, and a comparator in relieving drug‐induced xerostomia. This was an open‐label, randomized, 4‐period, cross‐over study in adult subjects with drug‐induced xerostomia and documented hyposalivation. During each of the four 1‐day periods, one product (one of three DC161 formulations or the comparator) was applied at T0 and then at T4h (before a meal). Mouth dryness and related symptoms were evaluated by the subject on a 100‐mm visual analog scale. The primary efficacy criterion was the area under the curve of the dry mouth evaluation (baseline to T4h) after the first application. The oral mucosa was examined by a dental specialist; tolerability and product acceptability were assessed by the subject. Twenty‐four subjects were randomized and completed the study. Despite large variability in data among the products, the selected aqueous formulation – DC161‐DP0292 – reduced the intensity of dryness of mouth at least as well as the comparator; DC161‐DP0292 provided a fast relief and a long‐lasting effect on mouth dryness. Both products improved other symptoms such as swallowing and speaking, even when applied just prior to a meal. DC161‐DP0292 was well tolerated and rated by subjects as providing a slightly higher acceptability of taste/aftertaste, texture, and lubricating effect than the comparator. No clinically relevant signs were reported for any product following the oral examination. DC161‐DP0292 provides fast and long‐acting symptomatic relief and is a relevant new treatment for drug‐induced xerostomia.
The offloading model for green base stations in hybrid energy networks with multiple objectives
Authors: Wei Yifei , Ren Chenying , Song Mei , Yu Richard 
Published: May 2016

SummaryBased on green energy prediction and storage, a novel green base station (GBS) offloading model is proposed and can be employed with multiple objectives in this paper to save energy. By predicting the value of green energy collected by GBS and updating the residual energy of each GBS, we can obtain the maximum number of users that each GBS can offload theoretically. Then, the optimum number of users should be calculated in order to achieve different network performance. Eventually, under the restrictions of the maximum number of users and the optimum number of users, we can finish offloading for traditional base station in the network. Simulation results demonstrate that through the proposed GBS offloading model, we can fulfill compromise between maximizing green energy utilization and load balancing in the offloading process, and the effect of energy saving is remarkable. Copyright © 2016 John Wiley & Sons, Ltd.
Factors Affecting the Statistical Properties of Sea Clutter
Authors: MATSUKUMA TOSHIHARU , SAYAMA SHUJI , ISHII SEISHIRO 
Published: May 2016

SUMMARYWe observed sea clutter in the sea area east of the Daini Kaiho sea fort in Tokyo Bay using an X‐band radar, and obtained data from 21,996 cells by 47 consecutive observations. In order to investigate the statistical properties, we performed estimation of parameters by maximum likelihood estimation and a test of goodness of fit by the Akaike Information Criterion (AIC), as models for the Weibull, log‐Weibull, and log‐Normal distributions. The reflected intensity distribution of sea clutter was found to obey the Weibull distribution better than any other distribution, and we therefore made a study using the shape parameter of the Weibull distribution. It was found that sea conditions such as swells and wind waves affect the statistical properties of sea clutter.
Multichannel Acoustic Echo Canceler Based on Particle Swarm Optimization
Authors: KIMOTO MASANORI , ASAMI TAKUYA 
Published: May 2016

SUMMARYIn multichannel acoustic echo cancelers based on linear combination, the uniqueness problem exists, namely, that adaptive filters cannot identify the correct echo paths due to highly cross‐correlated multichannel input signals. Preprocessing of the input signal is good candidates for solving this problem. However, it can have the drawbacks of degrading audio quality as a secondary problem. In this misadjustment problem, a universal solution is not derived in the conventional adaptive filter's optimization. In this paper, we propose a new multichannel adaptive echo canceling algorithm based on particle swarm optimization (PSO) without preprocessing of the input signals. PSO is a stochastic optimization technique inspired by the social behavior of bird flocking or fish schooling, and this is the first attempt to apply it to multichannel acoustic echo cancelers. By performing various simulations, we confirm that the proposed method can estimate correct echo paths with highly cross‐correlated input signals.
Improvement of Measurement Resolution of Depth Distribution in Cross‐Sectional Imaging Using Terahertz Wave
Authors: FUKUCHI TETSUO , FUSE NORIKAZU , MIZUNO MAYA , FUKUNAGA KAORI 
Published: May 2016

SUMMARYTime‐resolved reflection measurement using broadband, short terahertz pulses can provide cross‐sectional images of dielectric materials at different depths. Low‐frequency components which have responses over a wide time range may result in inclusion of spurious signals which arise from strong reflections at other depths. Model calculations showed that such spurious signals can be suppressed by application of a frequency filter of an appropriate center frequency. The effect of frequency filtering was investigated in cross‐sectional imaging of an IC card. Cross‐sectional images were obtained at depth intervals of 0.18 mm, which provided images at five different depth intervals. As a result of frequency filtering, spurious signals resulting from strong reflections at different depths could be reduced in intensity, which resulted in improvement of the measurement resolution of the depth distribution.
Electrical Properties of Polymer‐Grafted Carbon Nanotubes
Authors: HAYASHIDA KENICHI 
Published: May 2016

SUMMARYPoly(cyclohexyl methacrylate)s (PCHMAs) were grafted on carbon nanotubes (CNTs) using surface‐initiated polymerization technique. The electrical properties of the PCHMA‐grafted CNTs (PCHMA‐CNTs) were systematically measured under direct current (dc) and alternating current (ac), and compared with those of conventional nanocomposites prepared by blending PCHMA with CNT (PCHMA/CNT). At a comparable volume fraction of CNT, PCHMA‐CNT has a dc volume resistivity 15 orders of magnitude higher than PCHMA/CNT. This excellent electrical insulation of PCHMA‐CNT is achieved by the perfect isolation of individual CNTs owing to the high molecular weight PCHMAs densely grafted on the CNTs. The highly insulated PCHMA‐CNT showed the same ac frequency dependence of impedance as neat PCHMA. This means that PCHMA‐CNT is a dielectric. The dielectric performance of PCHMA‐CNT was evaluated by comparing with that of a barium titanate‐filled PCHMA composite.
Lateral and subsurface flows impact arctic coastal plain lake water budgets
Authors: Koch Joshua C. 
Published: May 2016

AbstractArctic thaw lakes are an important source of water for aquatic ecosystems, wildlife, and humans. Many recent studies have observed changes in Arctic surface waters related to climate warming and permafrost thaw; however, explaining the trends and predicting future responses to warming is difficult without a stronger fundamental understanding of Arctic lake water budgets. By measuring and simulating surface and subsurface hydrologic fluxes, this work quantified the water budgets of three lakes with varying levels of seasonal drainage, and tested the hypothesis that lateral and subsurface flows are a major component of the post‐snowmelt water budgets. A water budget focused only on post‐snowmelt surface water fluxes (stream discharge, precipitation, and evaporation) could not close the budget for two of three lakes, even when uncertainty in input parameters was rigorously considered using a Monte Carlo approach. The water budgets indicated large, positive residuals, consistent with up to 70% of mid‐summer inflows entering lakes from lateral fluxes. Lateral inflows and outflows were simulated based on three processes; supra‐permafrost subsurface inflows from basin‐edge polygonal ground, and exchange between seasonally drained lakes and their drained margins through runoff and evapotranspiration. Measurements and simulations indicate that rapid subsurface flow through highly conductive flowpaths in the polygonal ground can explain the majority of the inflow. Drained lakes were hydrologically connected to marshy areas on the lake margins, receiving water from runoff following precipitation and losing up to 38% of lake efflux to drained margin evapotranspiration. Lateral fluxes can be a major part of Arctic thaw lake water budgets and a major control on summertime lake water levels. Incorporating these dynamics into models will improve our ability to predict lake volume changes, solute fluxes, and habitat availability in the changing Arctic. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
Formation of multimers of bacterial collagens through introduction of specific sites for oxidative crosslinking
Authors: Stoichevska Violet , An Bo , Peng Yong Y. , Yigit Sezin , Vashi Aditya V. , Kaplan David L. , Werkmeister Jerome A. , Dumsday Geoff J. , Ramshaw John A. M. 
Published: May 2016

AbstractA range of non‐animal collagens has been described, derived from bacterial species, which form stable triple‐helical structures without the need for secondary modification to include hydroxyproline in the sequence. The non‐animal collagens studied to date are typically smaller than animal interstitial collagens, around one quarter the length and do not pack into large fibrillar aggregates like those that are formed by the major animal interstitial collagens. A consequence of this for biomedical products is that fabricated items, such as collagen sponges, are not as mechanically and dimensionally stable as those of animal collagens. In the present study, we examined the production of larger, polymeric forms of non‐animal collagens through introduction of tyrosine and cysteine residues that can form selective crosslinks through oxidation. These modifications allow the formation of larger aggregates of the non‐animal collagens. When Tyr residues were incorporated, gels were obtained. And with Cys soluble aggregates were formed. These materials can be formed into sponges that are more stable than those formed without these modifications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2369–2376, 2016.
Therapeutic Cell‐Cycle‐Decoy Efficacy of a Telomerase‐Dependent Adenovirus in an Orthotopic Model of Chemotherapy‐Resistant Human Stomach Carcinomatosis Peritonitis Visualized With FUCCI Imaging
Authors: Yano Shuya , Takehara Kiyoto , Tazawa Hiroshi , Kishimoto Hiroyuki , Urata Yasuo , Kagawa Shunsuke , Fujiwara Toshiyoshi , Hoffman Robert M. 
Published: May 2016

ABSTRACTWe have established an orthotopic nude‐mouse model of gastric cancer carcinomatosis peritonitis, a recalcitrant disease in human patients. Human MKN45 poorly‐differentiated human gastric cancer cells developed carcinomatosis peritonitis upon orthotopic transplantation in nude mice. The MKN45 cells expressed the fluorescent ubiquitination‐based cell cycle indicator (FUCCI) that color codes the phases of the cell cycle. The intra‐peritoneal tumors and ascites contained mostly quiescent G1/Go cancer cells visualized as red by FUCCI imaging. Cisplatinum (CDDP) treatment did not reduce bloody ascites, and larger tumors formed in the peritoneal cavity after CDDP treatment in an early‐stage carcinomatosis peritonitis orthotopic mouse model. Paclitaxel‐treated mice had reduced ascites, but also had large tumor masses in the peritonium after treatment with cancer cells mostly in G0/G1, visualized by FUCCI red. In contrast, OBP‐301 telomerase‐dependent adenovirus‐treated mice had no ascites and only small tumor nodules consisting of cancer cells mostly in S/G2 phases in the early‐stage carcinomatosis peritonitis model, visualized by FUCCI green. Furthermore, OBP‐301 significantly reduced the size of tumors (P < 0.01) and ascites even in a late‐stage carcinomatosis peritonitis model. These results suggest that quiescent peritoneally‐disseminated gastric cancer cells are resistant to conventional chemotherapy, but OBP‐301 significantly reduced the weight of the tumors and increased survival, suggesting clinical potential. J. Cell. Biochem. 118: 3635–3642, 2017. © 2016 Wiley Periodicals, Inc.