bluuebunny/crossref_metadata_2025_split huggingface dataset:
Slab Segmentation and Stacking in Mantle Transition Zone Controls Disparate Surface and Lower Mantle Subducting Rates and Complex Slab Morphology
Authors: Li Keqing , Hu Jiashun , Li Yida , Zhou Hao , Zhang Haijiang 
Published: September 2024

AbstractThe contradiction of high subducting plate rate (ranging from 4 to 9 cm/yr on Earth's surface) and low slab sinking rate (about 1 and 2 cm/yr in lower mantle) calls for significant slab deformation in the middle mantle. However, mechanisms that can account for both the deformation and the rate discrepancy have not been fully explored. Here, using 2‐D numerical models that incorporate grain size evolution, we propose a new slab deformation mode, slab segmentation and stacking, to accommodate the differential slab sinking rates. Our results show that the segmented slab due to faulting and grain‐size reduction may further break off and stack over itself as it encounters the high‐viscosity lower mantle. Stacked slabs slowly sink in the lower mantle, while periodic slab tearing hinders upward stress transmission, allowing shallow plates to subduct at a higher rate. This discovered mode also provides an alternative explanation for slab thickening in the lower mantle.
Anthropogenic Climate Change and Urbanization Exacerbate Risk of Hybrid Heat Extremes in China
Authors: Luo Sijia , Gu Xihui , Guan Yansong , Zheng Yanhui , Wang Lunche , Zhang Xiang , Cao Qian , Kong Dongdong , Li Jianfeng 
Published: September 2024

AbstractDry‐ and wet‐bulb temperature (Td and Tw) are usually to define heatwaves (HWs) which have been enhanced under anthropogenic climate change (ACC) and urbanization. However, responses of various types of HWs (i.e., dry HWs, only high Td; humid HWs, only high Tw; hybrid HWs, both high Td and Tw; total HWs, high Td or Tw), to ACC and urbanization remain unknown. In this study, both observations and simulations show significantly increasing occurrence probability of total HWs over China during 1971–2020, whereas this increase is mainly reflected in hybrid HWs, followed by dry HWs and humid HWs. 68.2%–93.0% of the observed increases in the above four types of HWs can be attributed to ACC; on the other hand, urbanization tends to suppress humid HWs but enhance dry HWs, as a result of contributing to the increase of hybrid HWs by 10.9%. Under future ACC, total HWs are projected to be more frequent as expected, which is mainly sourced from the increasing hybrid HWs because dry/humid HWs are projected to be steady/downward. As a consequence, urban population exposure to ACC‐induced total HWs would remarkably increase to 83.55 billion person‐days by the 2090s, 89.5% of which can be attributed to hybrid HWs. Urbanization would amplify this population exposure of ACC‐induced hybrid HWs from 74.79 billion person‐days to 110.9 billion person‐days. Our results underscore the importance of improving understanding of hybrid HWs in urban areas and developing targeted adaptation planning on a warmer planet.
Sediment Storage and Fluvial Sediment Transport Linkages Across an Experimental Flood Sequence
Authors: Hassan Marwan A. , Pierce J. Kevin , Chartrand Shawn M. 
Published: September 2024

AbstractRiver channels are maintained by coordination between flow hydraulics, sediment supply, riparian vegetation, and sediment transport. This coordination is challenging to understand in natural flow regimes, where climatic and environmental drivers produce episodic flood and sediment supply events. To better understand the response of channels to flood sequences, we have undertaken laboratory flume experiments on sediment storage and export across a sequence of alternating hydrographs. Our experiments indicate that accumulated sediment storage before floods predicts sediment transport during floods, with sediment storage depletion during floods causing a nonlinear variation of sediment‐transport rates through time. Likewise, sediment storage between floods follows a growth‐to‐saturation pattern, whereby the sediment transport gradually increases toward the sediment feed rate depending on the occupation of available sediment storage zones. To describe these non‐linear variations, we developed a mathematical model which represents sediment transport and storage as a coupled dynamical system. This work highlights the crucial role that within‐channel sediment storage and its history play in determining sediment export in rivers.
Reduced ENSO Variability During the Onset of the 4.2 ka Event
Authors: Dang Shaohua , Liu Zhongfang , Yu Kefu , Tao Shichen , Zhang Huiling , Wang Shaopeng , Lan Haimao 
Published: September 2024

AbstractAtmosphere‐ocean dynamics in the tropics play a key role in global climate change. An abrupt cooling event that occurred between 4500 and 3900a BP, known as the 4.2 ka event, has long been believed to be linked to changes in sea surface temperatures (SSTs) associated with intensified El Niño and Southern Oscillation (ENSO) variability. However, the precise timing and amplitude of ENSO variability during the 4.2 ka event remain uncertain, largely due to the lack of resolution in records from the ENSO‐sensitive regions. Here we present a 104‐year‐long monthly resolved coral record from the South China Sea that spans from 4400 to 4300 years BP, corresponding to the onset of the 4.2 ka event. Using the Sr/Ca paleo‐thermometry, we show a significant decrease in ENSO variability during this time interval compared to the modern period. The ENSO events decrease in the frequency from one every 3.5 years during the modern era to one every 5.6 years during the onset of the 4.2 ka event, with weaker magnitude in the latter period. This reduction in ENSO variability is largely associated with an intensification of the Pacific Walker circulation. We therefore suggest that ENSO variability was a response to, not a driver of, the development of the 4.2 ka event.
STAT3 promotes NLRP3 inflammasome activation by mediating NLRP3 mitochondrial translocation
Authors: Luo Ling , Wang Fupeng , Xu Xueming , Ma Mingliang , Kuang Guangyan , Zhang Yening , Wang Dan , Li Wei , Zhang Ningjie , Zhao Kai 
Published: September 2024

AbstractRecognition of the translocation of NLRP3 to various organelles has provided new insights for understanding how the NLRP3 inflammasome is activated by different stimuli. Mitochondria have already been demonstrated to be the site of NLRP3 inflammasome activation, and the latest research suggests that NLRP3 is first recruited to mitochondria, then disassociated, and subsequently recruited to the Golgi network. Although some mitochondrial factors have been found to contribute to the recruitment of NLRP3 to mitochondria, the detailed process of NLRP3 mitochondrial translocation remains unclear. Here, we identify a previously unknown role for Signal transducer and activator of transcription-3 (STAT3) in facilitating the translocation of NLRP3 to mitochondria. STAT3 interacts with NLRP3 and undergoes phosphorylation at Ser727 in response to several NLRP3 agonists, enabling the translocation of STAT3 and thus the bound NLRP3 to mitochondria. Disruption of the interaction between STAT3 and NLRP3 impairs the mitochondrial localization of NLRP3, specifically suppressing NLRP3 inflammasome activation both in vitro and in vivo. In summary, we demonstrate that STAT3 acts as a transporter for mitochondrial translocation of NLRP3 and provide new insight into the spatial regulation of NLRP3.
CMTM6 mediates the Warburg effect and promotes the liver metastasis of colorectal cancer
Authors: Shaha Aurpita , Wang Yuanguo , Wang Xianghu , Wang Dong , Guinovart David , Liu Bin , Kang Ningling 
Published: September 2024

AbstractLiver metastasis of colorectal cancer (CRC) is a leading cause of death among cancer patients. The overexpression of glucose transporter 1 (Glut1) and enhanced glucose uptake that are associated with the Warburg effect are frequently observed in CRC liver metastases, but the underlying mechanisms remain poorly understood. CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) regulates the intracellular trafficking of programmed death-ligand-1 (PD-L1); therefore, we investigated whether CMTM6 regulates Glut1 trafficking and the Warburg effect in CRC cells. We found that knocking down of CMTM6 by shRNA induced the lysosomal degradation of Glut1, decreased glucose uptake and glycolysis in CRC cells, and suppressed subcutaneous CRC growth in nude mice and liver metastasis in C57BL/6 mice. Mechanistically, CMTM6 forms a complex with Glut1 and Rab11 in the endosomes of CRC cells, and this complex is required for the Rab11-dependent transport of Glut1 to the plasma membrane and for the protection of Glut1 from lysosomal degradation. Multiomics revealed global transcriptomic changes in CMTM6-knockdown CRC cells that affected the transcriptomes of adjacent cancer-associated fibroblasts from CRC liver metastases. As a result of these transcriptomic changes, CMTM6-knockdown CRC cells exhibited a defect in the G2-to-M phase transition, reduced secretion of 60 cytokines/chemokines, and inability to recruit cancer-associated fibroblasts to support an immunosuppressive CRC liver metastasis microenvironment. Analysis of TCGA data confirmed that CMTM6 expression was increased in CRC patients and that elevated CMTM6 expression was associated with worse patient survival. Together, our data suggest that CMTM6 plays multiple roles in regulating the Warburg effect, transcriptome, and liver metastasis of CRC.
The roles and mechanisms of coding and noncoding RNA variations in cancer
Authors: Kim Sang Yean , Na Min Jeong , Yoon Sungpil , Shin Eunbi , Ha Jin Woong , Jeon Soyoung , Nam Suk Woo 
Published: September 2024

AbstractFunctional variations in coding and noncoding RNAs are crucial in tumorigenesis, with cancer-specific alterations often resulting from chemical modifications and posttranscriptional processes mediated by enzymes. These RNA variations have been linked to tumor cell proliferation, growth, metastasis, and drug resistance and are valuable for identifying diagnostic or prognostic cancer biomarkers. The diversity of posttranscriptional RNA modifications, such as splicing, polyadenylation, methylation, and editing, is particularly significant due to their prevalence and impact on cancer progression. Additionally, other modifications, including RNA acetylation, circularization, miRNA isomerization, and pseudouridination, are recognized as key contributors to cancer development. Understanding the mechanisms underlying these RNA modifications in cancer can enhance our knowledge of cancer biology and facilitate the development of innovative therapeutic strategies. Targeting these RNA modifications and their regulatory enzymes may pave the way for novel RNA-based therapies, enabling tailored interventions for specific cancer subtypes. This review provides a comprehensive overview of the roles and mechanisms of various coding and noncoding RNA modifications in cancer progression and highlights recent advancements in RNA-based therapeutic applications.
Octave-spanning Kerr soliton frequency combs in dispersion- and dissipation-engineered lithium niobate microresonators
Authors: Song Yunxiang , Hu Yaowen , Zhu Xinrui , Yang Kiyoul , Lončar Marko 
Published: September 2024

AbstractDissipative Kerr solitons from optical microresonators, commonly referred to as soliton microcombs, have been developed for a broad range of applications, including precision measurement, optical frequency synthesis, and ultra-stable microwave and millimeter wave generation, all on a chip. An important goal for microcombs is self-referencing, which requires octave-spanning bandwidths to detect and stabilize the comb carrier envelope offset frequency. Further, detection and locking of the comb spacings are often achieved using frequency division by electro-optic modulation. The thin-film lithium niobate photonic platform, with its low loss, strong second- and third-order nonlinearities, as well as large Pockels effect, is ideally suited for these tasks. However, octave-spanning soliton microcombs are challenging to demonstrate on this platform, largely complicated by strong Raman effects hindering reliable fabrication of soliton devices. Here, we demonstrate entirely connected and octave-spanning soliton microcombs on thin-film lithium niobate. With appropriate control over microresonator free spectral range and dissipation spectrum, we show that soliton-inhibiting Raman effects are suppressed, and soliton devices are fabricated with near-unity yield. Our work offers an unambiguous method for soliton generation on strongly Raman-active materials. Further, it anticipates monolithically integrated, self-referenced frequency standards in conjunction with established technologies, such as periodically poled waveguides and electro-optic modulators, on thin-film lithium niobate.
Multifaceted control of focal points along an arbitrary 3D curved trajectory
Authors: Ansari Muhammad Afnan , Ahmed Hammad , Li Yan , Wang Guanchao , Callaghan Jemma E. , Wang Ruoxing , Downing James , Chen Xianzhong 
Published: September 2024

AbstractMetalenses can integrate the functionalities of multiple optical components thanks to the unprecedented capability of optical metasurfaces in light control. With the rapid development of optical metasurfaces, metalenses continue to evolve. Polarization and color play a very important role in understanding optics and serve as valuable tools for gaining insights into our world. Benefiting from the design flexibility of metasurfaces, we propose and experimentally demonstrate a super metalens that can realize multifaceted control of focal points along any 3D curved trajectory. The wavelengths and polarization states of all focal points are engineered in a desirable manner. The super metalens can simultaneously realize customized 3D positioning, polarization states, and wavelengths of focal points, which are experimentally demonstrated with incident wavelengths ranging from 501 to 700 nm. We further showcase the application of the developed super metalenses in 3D optical distance measurement. The compact nature of metasurfaces and unique properties of the proposed super metalenses hold promise to dramatically miniaturize and simplify the optical architecture for applications in optical metrology, imaging, detection, and security.
Thermo-optical tweezers based on photothermal waveguides
Authors: Li Fuwang , Wei Jian , Qin Xiaomei , Chen Xue , Chen Dawei , Zhang Wentao , Han Jiaguang , Yuan Libo , Deng Hongchang 
Published: September 2024

AbstractField-controlled micromanipulation represents a pivotal technique for handling microparticles, yet conventional methods often risk physical damage to targets. Here, we discovered a completely new mechanism for true noncontact manipulation through photothermal effects, called thermal-optical tweezers. We employ a laser self-assembly photothermal waveguide (PTW) for dynamic microparticle manipulation. This waveguide demonstrates superior photothermal conversion and precision control, generating a nonisothermal temperature field. The interaction of thermal convection and thermophoresis within this field creates a microfluidic potential well, enabling noncontact and nondestructive particle manipulation. By varying the path of PTWs in lithography and manipulating laser loading modes, diverse manipulation strategies, such as Z-shaped migration, periodic oscillation, and directional transport, are achievable. Our innovative noninvasive micromanipulation technology minimizes not only physical damage to target objects but also enables precise and diverse manipulation of micro entities, opening up new avenues for the photothermal control of cells and biomolecules.
Circulating tumor cells: from new biological insights to clinical practice
Authors: Gu Xuyu , Wei Shiyou , Lv Xin 
Published: September 2024

AbstractThe primary reason for high mortality rates among cancer patients is metastasis, where tumor cells migrate through the bloodstream from the original site to other parts of the body. Recent advancements in technology have significantly enhanced our comprehension of the mechanisms behind the bloodborne spread of circulating tumor cells (CTCs). One critical process, DNA methylation, regulates gene expression and chromosome stability, thus maintaining dynamic equilibrium in the body. Global hypomethylation and locus-specific hypermethylation are examples of changes in DNA methylation patterns that are pivotal to carcinogenesis. This comprehensive review first provides an overview of the various processes that contribute to the formation of CTCs, including epithelial-mesenchymal transition (EMT), immune surveillance, and colonization. We then conduct an in-depth analysis of how modifications in DNA methylation within CTCs impact each of these critical stages during CTC dissemination. Furthermore, we explored potential clinical implications of changes in DNA methylation in CTCs for patients with cancer. By understanding these epigenetic modifications, we can gain insights into the metastatic process and identify new biomarkers for early detection, prognosis, and targeted therapies. This review aims to bridge the gap between basic research and clinical application, highlighting the significance of DNA methylation in the context of cancer metastasis and offering new avenues for improving patient outcomes.
Dopaminergic neurons lacking Caspase-3 avoid apoptosis but undergo necrosis after MPTP treatment inducing a Galectin-3-dependent selective microglial phagocytic response
Authors: García-Revilla Juan , Ruiz Rocío , Espinosa-Oliva Ana M. , Santiago Marti , García-Domínguez Irene , Camprubí-Ferrer Lluís , Bachiller Sara , Deierborg Tomas , Joseph Bertrand , de Pablos Rocío M. , Rodríguez-Gómez José A. , Venero José Luis 
Published: September 2024

AbstractParkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the Substantia nigra pars compacta (SNpc). Apoptosis is thought to play a critical role in the progression of PD, and thus understanding the effects of antiapoptotic strategies is crucial for developing potential therapies. In this study, we developed a unique genetic model to selectively delete Casp3, the gene encoding the apoptotic protein caspase-3, in dopaminergic neurons (TH-C3KO) and investigated its effects in response to a subacute regime of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration, which is known to trigger apoptotic loss of SNpc dopaminergic neurons. We found that Casp3 deletion did not protect the dopaminergic system in the long term. Instead, we observed a switch in the cell death pathway from apoptosis in wild-type mice to necrosis in TH-C3KO mice. Notably, we did not find any evidence of necroptosis in our model or in in vitro experiments using primary dopaminergic cultures exposed to 1-methyl-4-phenylpyridinium in the presence of pan-caspase/caspase-8 inhibitors. Furthermore, we detected an exacerbated microglial response in the ventral mesencephalon of TH-C3KO mice in response to MPTP, which mimicked the microglia neurodegenerative phenotype (MGnD). Under these conditions, it was evident the presence of numerous microglial phagocytic cups wrapping around apparently viable dopaminergic cell bodies that were inherently associated with galectin-3 expression. We provide evidence that microglia exhibit phagocytic activity towards both dead and stressed viable dopaminergic neurons through a galectin-3-dependent mechanism. Overall, our findings suggest that inhibiting apoptosis is not a beneficial strategy for treating PD. Instead, targeting galectin-3 and modulating microglial response may be more promising approaches for slowing PD progression.
cirSIRT5 induces ferroptosis in bladder cancer by forming a ternary complex with SYVN1/PHGDH
Authors: Li Weijian , Ou Yuxi , Ye Fangdie , Cheng Zhang , Chen Ziang , Zhou Quan , Yan Xiang , Jiang Haowen 
Published: September 2024

AbstractBladder cancer (BC) represents a prevalent and formidable malignancy necessitating innovative diagnostic and therapeutic strategies. Circular RNAs (circRNAs) have emerged as crucial regulators in cancer biology. In this study, we comprehensively evaluated ferroptosis levels in BC cells utilizing techniques encompassing lipid peroxidation assessment, transmission electron microscopy, and malondialdehyde (MDA) measurement. Additionally, we probed into the mechanistic intricacies by which circRNAs govern BC, employing RNA pull-down, RNA immunoprecipitation (RIP), and immunoprecipitation (IP) assays. Our investigation unveiled circSIRT5, which displayed significant downregulation in BC. Notably, circSIRT5 emerged as a promising prognostic marker, with diminished expression correlating with unfavorable clinical outcomes. Functionally, circSIRT5 was identified as an inhibitor of BC progression both in vitro and in vivo. Mechanistically, circSIRT5 exerted its tumor-suppressive activities through the formation of a ternary complex involving circSIRT5, SYVN1, and PHGDH. This complex enhanced the ubiquitination and subsequent degradation of PHGDH, ultimately promoting ferroptosis in BC cells. This ferroptotic process contributed significantly to the inhibition of tumor growth and metastasis in BC. In addition, FUS was found to accelerate the biogenesis of circSIRT5 in BC. These findings provide valuable insights into the pivotal role of circSIRT5 in BC pathogenesis, underscoring its potential as a diagnostic biomarker and therapeutic target for this malignancy.
Neurovascular coupling and CO2 interrogate distinct vascular regulations
Authors: Tournissac Marine , Chaigneau Emmanuelle , Pfister Sonia , Aydin Ali-Kemal , Goulam Houssen Yannick , O’Herron Philip , Filosa Jessica , Collot Mayeul , Joutel Anne , Charpak Serge 
Published: September 2024

AbstractNeurovascular coupling (NVC), which mediates rapid increases in cerebral blood flow in response to neuronal activation, is commonly used to map brain activation or dysfunction. Here we tested the reemerging hypothesis that CO2 generated by neuronal metabolism contributes to NVC. We combined functional ultrasound and two-photon imaging in the mouse barrel cortex to specifically examine the onsets of local changes in vessel diameter, blood flow dynamics, vascular/perivascular/intracellular pH, and intracellular calcium signals along the vascular arbor in response to a short and strong CO2 challenge (10 s, 20%) and whisker stimulation. We report that the brief hypercapnia reversibly acidifies all cells of the arteriole wall and the periarteriolar space 3–4 s prior to the arteriole dilation. During this prolonged lag period, NVC triggered by whisker stimulation is not affected by the acidification of the entire neurovascular unit. As it also persists under condition of continuous inflow of CO2, we conclude that CO2 is not involved in NVC.