bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metrological Assessment of Analytical Procedures Used for Semi-micro and Micro Determination of Water in Lyophilisates
Authors: Turundaeva A. A. , Mamashina E. A. , Kuleshova S. I. , Grigorieva S. E. , Ryzhova A. A. 
Published: September 2024

INTRODUCTION. The metrological characterisation of analytical procedures helps in selecting a procedure that will provide reliable and consistent results. This is particularly relevant in cases where a pharmacopoeial standard includes several test methods for a quality parameter of a medicinal product. For example, the water content of a lyophilisate can be measured by volumetric or coulometric Karl Fischer titration (semi-micro and micro determination) and by the loss on drying.AIM. This study aimed to investigate the correlation between the method selected for the determination of water content in a lyophilisate and the results obtained by this method via analysis of variance (ANOVA), as well as to evaluate the uncertainty of water content measurements by Karl Fischer titration.MATERIALS AND METHODS. The study focused on a lyophilised micafungin medicinal product. The water content in the lyophilisate samples was measured by Karl Fischer titration (semi-micro and micro determination) and, additionally, by the loss on drying as outlined in the Pharmacopoeia of the Eurasian Economic Union (General Monograph 2.5.1.14 Lyophilisates). The authors performed ANOVA using Microsoft Excel to assess the effect of the test method on the results. The authors conducted statistical analysis of the experimental results, including Fisher's test to assess the reproducibility and Student's test to compare the mean results obtained by two different methods. To assess measurement uncertainty, the authors calculated confidence interval limits at confidence levels of 0.95 and 0.99.RESULTS. ANOVA demonstrated that the method selected to determine the lyophilisate water content had an effect on the results obtained. Karl Fischer titration (semi-micro and micro determination) provided reproducible results; the F-values calculated for four lyophilisate batches (F1=2.3440, F2=1.0762, F3=3.5302, and F4=1.0989) were lower than the critical F-value (Fcrit(0.95;2;2)=19.000). The mean results of different methods were statistically dissimilar; the calculated t-values (t1=9.2391, t2=11.4847, t3=11.0041, and t4=33.6502) exceeded the critical t-value (tcrit(0.95;2)=4.3027). To assess the measurement uncertainty, the authors calculated two-sided confidence interval limits using Student's test at confidence levels of 0.95 and 0.99. The measurement uncertainty of the semi-micro method was lower than that of the micro method.CONCLUSIONS. The results of water determination in the micafungin lyophilisate depend on the method used. Micafungin water content is not commonly quantified by the loss on drying, and the methods of semi-micro and micro determination are not interchangeable for this purpose. Further studies are required to estimate bias and include the estimate in the measurement uncertainty budget.
The influence of planting density on the oil and fatty acids content of soybean in hydroponic and soil conditions of the Ararat Valley
Authors: Mairapetya Stepan , Tadevosyan Anna , Tovmasyan Anahit , Asatryan Armenuhi , Efimenko Sergey , Efimenko Svetlana , Matevosyan Artur 
Published: September 2024

Background: Plant seed oils are major renewable resources from nature that can be used in multiple applications. Oils and fats are a vital component of human diets. About 1/3 of the daily energy requirements of a healthy diet come from fats. Each branch of the food industry has its own demands for the fatty acid composition of seed oils. High amounts of polyunsaturated fatty acids are a requirement of healthy diets. However, food manufacturers need highly saturated fatty acids because they need oil that is resistant to high temperatures and oxidation. Soybean oil is second only behind palm oil as the most commercially abundant plant oil globally. Soybean has been recognized for its agricultural importance and their various positive effects on human health.
Objective: to identify the quantitative changes of soybean fatty acids depending on the planting density and growing conditions in the Ararat Valley of Armenia.
Methods: Soybean was grown in hydroponic and soil conditions of the Ararat Valley. The seeds were sown in the middle of April. Experiments were carried out in hydroponic equipment and soil with different planting densities (30, 50, 70 and 90 plants/m2). The oil content was measured by using the pulsed nuclear magnetic resonance method. The composition of fatty acids in seed oil was analyzed by chromatographic method on "Chromatec Crystal 5000" GC.
Results: Oil content ranged from 19.6% to 24.4% in all variants. The maximum content was registered in soil with 30 plant/m2 planting density. Linoleic acid content ranged from 46.35 to 51.28% of the total fatty acid content, regardless of planting density and growing media. The content of linolenic acid ranged from 4.13 to 5.11% in all variants. The maximum content of ω-3 and the minimal content of ω-9 was recorded in hydroponics at 30 plants/m2 planting density. The highest percentage of stearic acid was observed in the soil variant with a planting density of 30 plants/m2. Interestingly, the variants did not differ in the total content of the 5 main fatty acids (98.84-98.95%). Growing medium had no significant effect on the total saturated fatty acids content; in all variants it ranged from 14.29% to 14.83%. Total unsaturated fatty acids content ranged from 85.2% to 85.7%. The hydroponic variant with a planting density of 30 plants/m2 had the lowest ratio of ω-6 and ω-3 fatty acids (10:1).
Conclusion: Planting density and growing media had a significant influence on the content of monounsaturated and polyunsaturated fatty acids. Under hydroponic conditions the lowest content of monounsaturated and the highest content of polyunsaturated fatty acids were observed at the lowest planting density (30 plants/m2), which can be used as a functional food for daily consumption.
Keywords: Glycine max (L.) Merr., soilless culture, ω-3, ω-6, ω-9, saturated acids.
The High Rising Terminal in the Intonation System of the Modern English Language
Authors: Sypacheva K. N. , Shamina E. A. 
Published: September 2024

Introduction. The article examines changes taking place in the intonation systems of modern varieties of the English language by analysing the use of the High Rising Terminal (HRT). Received pronunciation (RP), which is recognised as standard pronunciation in the United Kingdom, Australian English accents and Northern Irish English accents (accents of Belfast) have been chosen as the subject for this study. Intonation contours containing the HRT are compared in order to reveal any similar features regarding their realisation and functions. The results of this comparative analysis will show to what extent other varieties of English may be attributed to the changes in the intonation system of the modern RP. The present study is unique in that the material for the comparative analysis of the functions of the HRT includes recordings of spontaneous speech of the speakers of modern English accents. This study is relevant due to the growing interest in the modern changes in the intonation systems of different modern English dialects. The results of the comparative analysis show whether these changes can be considered universal across different English dialects.Methodology and sources. The material for the present study includes audio samples of spontaneous speech represented by dialogues between native speakers of Standard British English, Australian English and Belfast English. The samples containing the HRT have been acoustically analysed. The lexical and communicative context of the samples have been evaluated in order to determine the functions of the phonetic contour.Results and discussion. One of the main findings of this study is a new function of the HRT in RP that has not been found in the classical descriptions of the accent. The acoustic analysis of the realisations of the HRT has also revealed a number of similar features between the modern accents of English analysed in this study.Conclusion. Many changes taking place in modern varieties of English have been caused by globalisation. Even though RP accent is considered to be the standard accent of British English, it is also subject to change.
Vo2Max Siswa Sekolah Basket Wirabhakti Lumajang
Authors: Syahab Afaf , Fathur Rohman Muhammad , Widiyanto Wahyu Eko , Topoyono Topoyono 
Published: September 2024

Permainan bolabasket merupakan cabang olahraga yang populer dunia dengan pemain dari berbagai kalangan masyarakat dari remaja sampai dewasa. Permainan bolabasket dengan yang memerlukan intensitas fisik tinggi membutuhkan fisik dan kebugaran yang prima untuk mencapai permainan pada level lebih yang tinggi. Penelitian ini yang bertujuan untuk mengetahui kapasitas aerobik (VO2Max) siswa sekolah basket Wirabhakti Lumajang yang tengah bersiap menuju ajang PERBASI CUP kelompok umur dibawah 15 tahun. Hasil penelitian menunjukkan bahwa siswa sekolah basket wirabhakti lumajang belum ada yang masuk kategori unggul. siswa laki-laki sekolah basket Wira Bahkti Lumajang Under 15 tahun yang masuk kategori sangat baik sekali dan sangat baik dengan persentase 0%. Kategori baik sebesar 7%, berkategori cukup sebesar 43% dengan kategori kurang sebesar 14%, dan dengan kategori kurang sekali sebesar 36%. Sedangkan untuk atlet perempuan sekolah basket Wira Bahkti Lumajang Under 15 tahun yang masuk kategori sangat baik sekali,Sangat baik dan baik memperoleh persentase 0%. Kategori cukup sebesar 14%, berkategori kurang sebesar 36%, dan kategori kurang sekali sebesar 50%.
Aktivitas E.coli dan Stapphylococcus terhadap Penambahan Lactobacillus dari Rebung Asam
Authors: Welkriana Putri Widelia , Halimatussa'diah Halimatussa'diah 
Published: September 2024

Lactic acid bacteria produce antimicrobial protein compounds. This compound can inhibit the development of gram-positive and negative bacteria. However, this compound is not harmful to intestinal microflora and is easily digested by enzymes in the digestive tract. This protein compound comes from fermented food products and other processed food products, one of which is sour bamboo shoots with a fermentation time of 7 days. In sour bamboo shoots, Lactobacillus sp. was found. with pure strains of FNCC 0027 and C410LI genes. This is the result of previous research. Tamarind bamboo shoots are one of the processed products found in Bengkulu province. This research aims to determine the optimal conditions for the compounds produced by these bacteria. The methods used include: BAL cultured, BAL confirmed, antibacterial BAL isolated, E. coli and Staphylococcus activity test, antibacterial test for proteolytic enzymes, and temperature and pH measurements. The results of the research showed that the effectiveness of E. coli activity was 65.5% and S. aureus was 21% after the two bacteria were given the addition of Lactobacillus brevis strain 2096 16S ribosomal RNA gene. At varying temperatures, the inhibition zone activity of the two bacteria was highest at 1000C, while the activity of the inhibition zone was highest at pH 6.
Faktor-Fsktor yang Berhubungan dengan Perilaku Seks Pranikah pada Mahasiswa Kesehatan di Kota Bandar Lampung
Authors: Wati Putri Vega , Sary Lolita , Muhani Nova , Amperaningsih Yuliati , Febriani Christin Angelina 
Published: September 2024

Program kampus sehat mendukung dan mendorong setiap mahasiswa di lingkungan kampus untuk mewujudkan perubahan perilaku khususnya perilaku kesehatan reproduksi yang sehat. Tujuan dari penelitian ini adalah diketahuinya faktor-faktor yang berhubungan dengan perilaku seks pranikah pada mahasiswa kesehatan di Kota Bandar Lampung. Jenis penelitian kuantatif, populasi seluruh mahasiswa aktif program studi kesehatan semester genap 2022- 2023 berjumlah 721 orang dan sampel sebanyak 345 orang. Alat ukur kuesioner dan data dianalisis menggunakan chi square dan regresi logistik. Hasil penelitian didapatkan responden tidak berperilaku seks pranikah sebanyak 267 orang (77,4%), pengetahuan tentang kesehatan reproduksi baik sebanyak 199 orang (57,7%), sikap menolak perilaku seksual pranikah 201 orang (58,3%), tidak terdapat pengaruh teman sebaya 209 orang (60,6%), tidak terpapar media/konten pornografi 227 orang (65,8%). Terdapat hubungan pengetahuan (p- value 0,05 OR= 1,7), sikap akan perilaku seksual pranikah (p-value 0,002 OR=2,3), pengaruh teman sebaya (p-value 0,000 OR=5,4), paparan media/konten pornografi (p-value 0,017 OR=1,9) terhadap perilaku seks pranikah. Pengaruh teman adalah variabel yang paling berhubungan dengan perilaku seks pranikah dengan OR 5,0. Hendaknya memfasilitasi layanan kesehatan reproduksi remaja dengan edukasi menggunakan alat bantu poster, leaflet banner, melakukan talksow serta membentuk Pusat Informasi dan Konseling Remaja (PIK-R) sebagai wadah teman sebaya menyebarluaskan infomasi tentang kesehatan reproduksi Kata kunci: perilaku sesksual pranikah, teman sebaya, mahasiswa kesehatan
Penyuluhan Kesehatan Telinga Pasien Poli THT-KL RSUD dr H. Abdul Moeloek Provinsi Lampung Tahun 2024
Authors: Imanto Mukhlis , Permata Alfiah Yusi , Adila Naza Tsasbita Hayuning 
Published: September 2024

Kesehatan telinga dan pendengaran merupakan hal penting yang perlu perhatian khusus. Gangguan pada telinga dan pendengaran dapat mengakibatkan beberapa kelainan, seperti penyakit infeksi telinga, masalah keseimbangan hingga gangguan pendengaran permanen. Kesehatan telinga dan pendengaran yang baik dapat dicapai dengan melakukan kebiasaan dan sikap yang sehat dengan didasari pengetahuan yang baik dalam hal kesehatan telinga dan pendengaran. Kegiatan ini bertujuan memberikan pengetahuan mengenai menjaga kesehatan telinga dan Pemahaman Tentang Gangguan pendengaran. Kegiatan dilakukan Poli THT-KL RSUD dr H. Abdul Moeloek Provinsi Lampung. Kegiatan diawali dengan memberikan penyuluhan mengenai menjaga kesehatan telinga dilanjutkan dengan Pemaparan materi tentang faktor dan komplikasi pendengaran. Sebelum dan sesudah penyuluhan diberikan pre dan post test dengan hasil rata-rata 53 dan 85, terdapat peningkatan pengetahuan yang signifikan pada pasien mengenai kesehatan telinga. Melalui kegiatan ini terdapat peningkatan pengetahuan dari pasien-pasien Poli THT-KL RSUD dr H. Abdul Moeloek Provinsi Lampung mengenai cara menjaga kesehatan telinga dan faktor-faktor yang mempengaruhi gangguan pendengaran.
Pengaruh Edukasi Terhadap Pengetahuan Ibu tentang Stimulasi dalam Perkembangan Bahasa Balita usia 2-3 Tahun
Authors: Ifayanti Hikmah , Nadia Ara , Agustina Rika 
Published: September 2024

Berdasarkan penilaian perkembangan anak di Puskesmas Beringin Raya, Kota Bandar Lampung pada tahun 2023, dari 435 anak, diperoleh 11 (2,5%) mengalami keterlambatan perkembangan. Tujuan dari penelitian ini adalah dimengetahuinya pengaruh edukasi dengan media Booklet terhadap pengetahuan ibu tentang stimulasi dalam perkembangan bahasa anak usia 2-3 tahun di Taman Kanak-kanak di Kelurahan Beringin Raya, Kota Bandar Lampung. Jenis penelitian ini adalah kuantitatif dengan rancangan pra-eksperimental menggunakan pendekatan one-group pretest dan posttest. Sampel terdiri dari 39 peserta yang dipilih menggunakan teknik accidental sampling. Pengumpulan data dilakukan dengan menggunakan kuesioner. Hasil penelitian mengungkapkan bahwa rata-rata skor pengetahuan ibu tentang stimulasi bahasa pada balita usia 2-3 tahun sebelum menerima edukasi adalah 56,9, sedangkan setelah menerima edukasi meningkat menjadi 78,0. Terdapat pengaruh edukasi dengan media booklet terhadap pengetahuan ibu tentang stimulasi dalam perkembanagn bahasa balita usia 2-3 tahun di Taman Kanak-kanak Kelurahan Beringin Raya, Kota Bandar Lampung.
PARTISIPASI MASYARAKAT TERHADAP REHABILITASI HUTAN DI DESA JAGONG JEGET KECAMATAN JAGONG JEGET
Authors: Yanto Indri 
Published: September 2024

Penelitian ini membahas tentang partisipasi masyarakat terhadap rehabilitasi hutan di Kampung Jagong Jeget Kecamatan Jagong jeget Kabupaten Aceh Tengah berdasarkan teori Arnstein. Penelitian ini menggunakan metode kualitatif dengan membagikan kuesioner penelitian. Untuk mengetahui tingkatan partisipasi masyarakat terhadap rehabilitasi di kampung Jagong Jeget Kecamatan Jagong Jeget Kabupaten Aceh Tengah Pengumpulan data dilakukan dengan menyebarkan kuesioner kepada responden berdasarkan delapan tangga partisipasi Arnstein sehingga dapat dikategorikan menjadi 3 tingkatan partisipasi, yaitu tinggi, sedang dan rendah. Seluruh parameter yang diberikan kepada 38 responden berada pada posisi rendah. Persentase tertinggi berada pada tahap Manipulasi (manipulation) dengan presentase sebesar 14,8 % dan persentase terendah berada pada tahapan Terapi (theraphy) dan Kemitraan (partnership) dengan presentase sebesar 11,02 %. Artinya seluruh parameter derajat partisipasi masyarakat masih belum optimal. Dengan demikian dapat disimpulkan bahwa sebagian besar masyarakat di Kampung Jagong Jeget Kecamatan Jagong jeget Kabupaten Aceh Tengah masih kurang ikut serta dalam berpartisipasi untuk melakukan rehabilitasi hutan.
DAMPAK KEBERADAAN TEMPAT PEMBUANGAN AKHIR (TPA) SAMPAH TERHADAP KEADAAN SOSIAL EKONOMI PEMULUNG DI DESA TANJUNG SELAMAT KECAMATAN SUNGGAL KABUPATEN DELI SERDANG
Authors: Lara Anjelita Tarigan  , Sintong Mahara 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui bagaimana dampak keberadaan tempat pembuangan akhir sampah terhadap keadaan sosial ekonomi masyarakat di Desa Tanjung Selamat Kecamatan Sunggal Kabupaten Deli Serdang metode pada penelitian ini adalah deskriptif kualitatif data yang diperoleh dengan melakukan observasi dan wawancara kepada responden. Hasil penelitian menunjukkan bahwa: Dampak positif yang di sebabkan oleh adanya tempat pembuangan akhir sampah ini terhadap keadaan Sosial ekonomi pemulung yang bekerja di tempat pembuangan akhir sampah sangat membantu para pemulung yang mampu membuka lapangan pekerjaan bagi para pemulung dan Menambah pendapatan baik dalam memenuhi kebutuhan sehari-hari dan untuk menyekolahkan anak-anak mereka, bahkan ada pemulung yang mengkuliahkan anaknya sampai ke perguruan tinggi dari hasil ia memulung selama bertahun-tahun akan tetapi ada juga dampak negatif yang disebabkan oleh adanya tempat pembuangan akhir sampah di antaranya yaitu sebagian pemulung pernah menderita penyakit demam berdarah, tipes dan gatal gatal. Selain rentan terhadap penyakit oleh Qada dan Sampah pemulung juga memiliki kualitas udara yang kurang baik di rumahnya hal ini disebabkan karena keberadaan truk sampah yang berlalu Lalang sehingga dapat menyumbang debu, asap dan bau yang tidak sedap.
A CT-based radiomics predictive nomogram to identify pulmonary tuberculosis from community-acquired pneumonia: a multicenter cohort study
Authors: Li Pulin , Wang Jiling , Tang Min , Li Min , Han Rui , Zhou Sijing , Wu Xingwang , Wang Ran 
Published: September 2024

PurposeTo develop a predictive nomogram based on computed tomography (CT) radiomics to distinguish pulmonary tuberculosis (PTB) from community-acquired pneumonia (CAP).MethodsA total of 195 PTB patients and 163 CAP patients were enrolled from three hospitals. It is divided into a training cohort, a testing cohort and validation cohort. Clinical models were established by using significantly correlated clinical features. Radiomics features were screened by the least absolute shrinkage and selection operator (LASSO) algorithm. Radiomics scores (Radscore) were calculated from the formula of radiomics features. Clinical radiomics conjoint nomogram was established according to Radscore and clinical features, and the diagnostic performance of the model was evaluated by receiver operating characteristic (ROC) curve analysis.ResultsTwo clinical features and 12 radiomic features were selected as optimal predictors for the establishment of clinical radiomics conjoint nomogram. The results showed that the predictive nomogram had an outstanding ability to discriminate between the two diseases, and the AUC of the training cohort was 0.947 (95% CI, 0.916-0.979), testing cohort was 0.888 (95% CI, 0.814-0.961) and that of the validation cohort was 0.850 (95% CI, 0.778-0.922). Decision curve analysis (DCA) indicated that the nomogram has outstanding clinical value.ConclusionsThis study developed a clinical radiomics model that uses radiomics features to identify PTB from CAP. This model provides valuable guidance to clinicians in identifying PTB.
Do peers matter? The influence of peers' self-regulation on individual self-regulation: a longitudinal multilevel analysis
Authors: Busching Robert 
Published: September 2024

Introduction:Self-regulation is important for social as well as academic success, and research shows that it is also shaped by social interactions. At the same time, peers shape children's development in many domains. Linking these two concepts, it can be predicted that children who are surrounded by peers with a high level of self-regulation later show higher self-regulation themselves compared to those who are surrounded by peers with a low level of self-regulation.MethodsTo test this assumption, a longitudinal sample with N = 1,658 participants in 181 classrooms (μage = 8.37) was analyzed. The self-regulation facets of working memory updating, inhibition, and flexibility were measured using an age-appropriate version of the Stroop test, the repeat-digits-backward test, and the Wisconsin card-sorting task. Based on this data, a score for both the individual and class level was calculated.ResultsThe results show that the classmates‘ level of self-regulation predicted later individual self-regulation above the individual self-regulation score. While neither age nor gender moderated this relationship, there was a significant cross-level interaction: Especially individuals with a low level of cognitive flexibility gained from being surrounded by peers with a high level of cognitive flexibility.DiscussionWhile the results show that peers constitute an important social context for the development of self-regulation, this fact is often only a minor point in modern self-regulation theories.
The application and clinical translation of the self-evolving machine learning methods in predicting diabetic retinopathy and visualizing clinical transformation
Authors: Li Binbin , Hu Liqun , Zhang Siqing , Li Shaojun , Tang Wei , Chen Guishang 
Published: September 2024

ObjectiveThis study aims to analyze the application and clinical translation value of the self-evolving machine learning methods in predicting diabetic retinopathy and visualizing clinical outcomes.MethodsA retrospective study was conducted on 300 diabetic patients admitted to our hospital between January 2022 and October 2023. The patients were divided into a diabetic retinopathy group (n=150) and a non-diabetic retinopathy group (n=150). The improved Beetle Antennae Search (IBAS) was used for hyperparameter optimization in machine learning, and a self-evolving machine learning model based on XGBoost was developed. Value analysis was performed on the predictive features for diabetic retinopathy selected through multifactor logistic regression analysis, followed by the construction of a visualization system to calculate the risk of diabetic retinopathy occurrence.ResultsMultifactor logistic regression analysis revealed that being male, having a longer disease duration, higher systolic blood pressure, fasting blood glucose, glycosylated hemoglobin, low-density lipoprotein cholesterol, and urine albumin-to-creatinine ratio were risk factors for the development of diabetic retinopathy, while non-pharmacological treatment was a protective factor. The self-evolving machine learning model demonstrated significant performance advantages in early diagnosis and prediction of diabetic retinopathy occurrence.ConclusionThe application of the self-evolving machine learning models can assist in identifying features associated with diabetic retinopathy in clinical settings, enabling early prediction of disease occurrence and aiding in the formulation of treatment plans to improve patient prognosis.