bluuebunny/crossref_metadata_2025_split huggingface dataset:
Educational and therapeutic qualities of the Bones for Life method – Third Age University lectures
Authors: Salamon-Krakowska Katarzyna , Ławreszuk Ewa , Stępień Agnieszka 
Published: July 2016

AbstractThe advantages of the Bones for Life method (BFL) when working with the elderly cannot be overestimated. Bones for Life method may constitute an example of a modern practice of oneself, an example of empowerment which differs from the one offered by mass culture. Thanks to its philosophical underpinnings and consistency the BFL method is holistic in its approach i.e. it addresses the physical as well as the spiritual aspect of human nature thus avoiding treating instrumentally the psycho-physical unity of human beings. What is also significant in the BFL method is its ethical aspect as it combines therapeutic and educational qualities. Its constitutes an integral part of somatic education (a branch of knowledge still little known in Poland) and thus fosters personal development irrespective of the person’s age. Given the increase in demand for different forms of activity tailored for senior citizens perhaps we ought to take a closer look at methods well-known and practised elsewhere in the world.
Mechanotransduction as one of potential mechanisms of impact of massage on the organism
Authors: Andrzejewski Waldemar 
Published: July 2016

AbstractMassage as a mechanical factor acting on the human body has long been used in the prophylaxis, treatment and restoration of functions when they were disturbed. Its effects on the body have not been explicitly confirmed and require further research. Mechanotransduction may be a potential mechanism of massage action. It is understood as a process in which the mechanical element is converted intracellularly into various types of electrical and chemical signals. Massage action consists primarily of the deformation of the connective tissue which is a component of various anatomical structures. During deformation of these structures, there comes to tension within the limits of their elasticity and thus to the transfer of pulling force via the integrins on the fibres forming the cell cytoskeleton inducing complex cellular reactions. They can be characterized by rapid changes occurring in tissues on hormonal basis or be of long-lasting nature consisting of the expression of growth factors initiating tissue structural adaptation to the changed external conditions.
Review of research on the impact of physical activity on mental state of the elderly
Authors: Morga Paulina , Traczyk Justyna , Wittenbeck Klaudyna , Zygmont Agnieszka 
Published: July 2016

AbstractThe aim of the review was to find the factors correlated to the state of mental and physical health of the elderly as well as the factors, behaviours and activities that can be influenced and potentially modified. We performed an analysis of results of research conducted in many places all across the world among the persons after the age of 50. The results of this research indicate a significant role of physical activity in functioning of the elderly. They show how it influences their performance of everyday activities, their mood and health. We discuss the research taking into account the diagnostic tools used, the interventions performed and their effectiveness.
Minnesota Leisure Time Physical Activity Questionnaire in medical practice and health promotion
Authors: Barabasz Monika , Lwow Felicja , Zadarko Emilian 
Published: July 2016

AbstractThe prevention of chronic diseases, especially metabolic disorders, is based on modification of behavioural risk factors, in particular eating habits and physical activity. Numerous population studies have demonstrated a relationship between regular physical activity and decreased levels of risk factors for CVD (cardiovascular disease), type 2 diabetes and some cancers. Increasing the level of physical activity as part of the programs implemented for disease prevention or health promotion for selected populations requires a behavioural diagnosis, whereby an essential element is the preferred leisure-time activity in terms of the structure of negative health indicators. Evaluation of physical activity under population studies requires a simple, validated and inexpensive tool to be used in medical practice or health promotion. The Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ) is a tool currently often used and validated with laboratory methods. Standard MLTPAQ allows for assessment of the level of physical activity undertaken in leisure time. The authors present an algorithm for assessing leisure-time physical activity level based on MLTPAQ. The paper also reviews the practical application of the MLTPAQ questionnaire on healthy and patient populations in Poland and other countries by specialists in public health, health promotion and in medical practice.
Long-term results of physiotherapy in treatment of bronchial asthma – case study
Authors: Hupa Michał 
Published: July 2016

AbstractBronchial asthma is a common disease in this day and age, but despite our vast knowledge on it, it still represents a great challenge for contemporary medicine. The paper describes a case of a bronchial asthma patient from the moment of diagnosis until the present day. Based on extensive documentation of multiple stays in sanatoriums, and of outpatient treatment, the paper shows the course of the disease, as well as the applied treatment, rehabilitation and diagnostic tests (spirometry, blood gas test, radiography) that gave grounds for objective assessment of patient’s health and demonstrated the improvement.
Calibration of a three-dimensional photodynamic therapy illumination system and its segmentation assessment for port-wine stains
Authors: Feng Yun , Hu Xiaoming , Zhou Ya , Wang Yong 
Published: July 2016

Abstract
The uniformity of light dosimetry is an important parameter that affects the efficacy of photodynamic therapy (PDT). Although this uniformity can be improved by a three-dimensional (3D) digital PDT illumination system, it has a low field-of-view (FOV) utilization rate. A checkerboard calibration method using color coding is proposed to calibrate both the projector and camera of the system with a broad common FOV. Experiments reveal that the proposed method increases the utilization rate by up to three times compared with noncolor-coding methods with almost the same accuracy. A fine distinction of phantom lesions in the 3D system can be obtained by clustering, which may be used to optimize the treatment and light-dosimetry evaluation.
Acute Resistance Exercise Performance Is Negatively Impacted by Prior Aerobic Endurance Exercise
Authors: Ratamess Nicholas A. , Kang Jie , Porfido Tara M. , Ismaili Craig P. , Selamie Soraya N. , Williams Briana D. , Kuper Jeremy D. , Bush Jill A. , Faigenbaum Avery D. 
Published: July 2016

Abstract
Ratamess, NA, Kang, J, Porfido, TM, Ismaili, CP, Selamie, SN, Williams, BD, Kuper, JD, Bush, JA, and Faigenbaum, AD. Acute resistance exercise performance is negatively impacted by prior aerobic endurance exercise. J Strength Cond Res 30(10): 2667–2681, 2016—The purpose of the present study was to examine acute resistance exercise (RE) performance after 4 different aerobic endurance (AE) protocols. Eleven healthy, resistance-trained men (21.0 ± 1.2 years) performed a control RE protocol and 4 RE protocols 10 minutes after different AE protocols in random sequence. The RE protocol consisted of 5 exercises (high pull, squat, bench press, deadlift, and push press) performed for 3 sets of 6–10 repetitions with 70–80% of one repetition-maximum (1RM) with 3-minute rest intervals in between sets. The AE protocols consisted of treadmill running at velocities corresponding to: (a) 60% of their V̇o
2 reserve (V̇o
2R) for 45 minutes (P1); (b) 75% of their V̇o
2R for 20 minutes (P2); (c) 90–100% of V̇o
2R in 3-minute intervals (1:1 ratio) for 5 sets (P3); and (d) 75% of V̇o
2R (4.5 mph) uphill (6–9% grade) for 20 minutes (P4). Completed repetitions, average power and velocity, heart rate (HR), and ratings of perceived exertion (RPE) were assessed each set. Protocols P1–P4 resulted in 9.1–18.6% fewer total repetitions performed compared with the control RE protocol with the squat experiencing the greatest reduction. Average power and velocity were significantly reduced for the high pull, squat, and bench press after most AE protocols. Ratings of perceived exertion values for the high pull and squat were significantly higher in P1–P4 compared with control. Heart rate was significantly higher during RE after P1–P4 compared with control by 4.3–5.5%. These results indicate acute RE performance is significantly compromised in healthy men after AE exercise of different type, intensity, and duration with largest reductions observed after high-intensity interval exercise.
Learning to Fish with Genetics: A Primer on the Vertebrate ModelDanio rerio
Authors: Holtzman Nathalia G , Iovine M Kathryn , Liang Jennifer O , Morris Jacqueline 
Published: July 2016

AbstractIn the last 30 years, the zebrafish has become a widely used model organism for research on vertebrate development and disease. Through a powerful combination of genetics and experimental embryology, significant inroads have been made into the regulation of embryonic axis formation, organogenesis, and the development of neural networks. Research with this model has also expanded into other areas, including the genetic regulation of aging, regeneration, and animal behavior. Zebrafish are a popular model because of the ease with which they can be maintained, their small size and low cost, the ability to obtain hundreds of embryos on a daily basis, and the accessibility, translucency, and rapidity of early developmental stages. This primer describes the swift progress of genetic approaches in zebrafish and highlights recent advances that have led to new insights into vertebrate biology.
Weaving a Tapestry from Threads Spun by Geneticists: The Series Perspectives on Genetics, 1987–2008
Authors: Dove William F 
Published: July 2016

Abstract
The Perspectives column was initiated in 1987 when Jan Drake, Editor-in-Chief of GENETICS, invited Jim Crow and William Dove to serve as coeditors of “Anecdotal, Historical, and Critical Commentaries.” As the series evolved over 21 years, under the guidance of Crow and Dove, the input of stories told by geneticists from many countries created a panorama of 20th-century genetics. Three recurrent themes are visible: how geneticists have created the science (as solitary investigators, in pairs, or in cooperative groups); how geneticists work hard, but find ways to have fun; and how public and private institutions have sustained the science of genetics, particularly in the United States. This article ends by considering how the Perspectives series and other communication formats can carry forward the core science of genetics from the 20th into the 21st century.
Complex Traits and Simple Systems: An Interview with Leonid Kruglyak
Authors: Kruglyak Leonid 
Published: July 2016

Abstract
The Genetics Society of America’s Edward Novitski Prize recognizes an extraordinary level of creativity and intellectual ingenuity in the solution of significant problems in genetics research. The 2016 winner, Leonid Kruglyak, has made innovative contributions to the fields of linkage analysis, population genetics, and genomics, while drawing on a combination of mathematical, computational, and experimental approaches. Among other achievements, his work on statistical standards for genome-wide linkage studies has transformed their experimental design, and the linkage analysis program GENEHUNTER has been used to identify hundreds of human disease loci. Kruglyak’s group also pioneered expression quantitative trait locus studies, which enabled variation in global gene expression to shed light on the genetics of complex human diseases. In recent years, his laboratory has focused on using genomic technology to establish Saccharomyces cerevisiae and Caenorhabditis elegans as model organisms for studies of complex genetic variation.
Bioética urbana: La ciudad como bien común
Authors: SARMIENTO MARÍA LAURA 
Published: July 2016

<p>Los principios de la sustentabilidad no tienen que ver sólo con el uso del territorio en cuanto a los principios ecológicos, sino además debemos lograr otras cuestiones que hacen a la sustentabilidad, como la democracia, la justicia, la igualdad, como el respeto al valor agregado que tienen las diversidades, tiene que ver con la participación de todos los ciudadanos y ciudadanas del mundo (Rivas 2013).Es en este sentido de sustentabilidad que nos interpela el estado de la realidad en las ciudades de las que somos partícipes como arquitectos/as y urbanistas. De este modo, nos preguntamos: ¿Cuál es la intención de la arquitectura por estos tiempos que corren?¿Qué lugar ocupa en la construcción de la ciudad la Carta de la Tierra y el Buen Vivir? ¿Qué desafíos debiera asumir la arquitectura en su relación con la ciudad, reivindicada  ésta como bien común?  Intentaremos dar cuenta de estas interpelaciones a los fines de trazar un primer esbozo acerca de acuerdos posibles para la construcción de la ciudad como bien común, en el que proponemos la construcción de una Bioética Urbana que contemple y reconozca el vínculo con las maneras de habitar diferentes a las convencionales y sea responsable de dicha diversidad y amplitud, haciéndola su sustento.</p>
APROXIMACIÓN A LA CAPACIDAD ECOSISTÉMICA NECESARIA PARA EL MACROCOMPLEJO EUROVEGAS, ESPAÑA
Authors: Córdoba Hernández Rafael 
Published: July 2016

<p>La crisis económica y social española reciente, la caída del mercado inmobiliario y el auge del turismo está provocando un resurgimiento de proyectos singulares, donde el ocio o la segunda residencia son la idea principal. En este contexto, surge el proyecto de construir un complejo de juego y ocio similar a Las Vegas, pero de menor tamaño, en una localidad próxima a la capital. Las motivaciones políticas y económicas derivadas de la posible creación de empleo por el proyecto dejaron de lado la valoración del posible impacto territorial que tendría.La falta de información sobre las negociaciones hizo que los pocos datos cuantificables del complejo fueran apareciendo en la prensa nacional de manera parcial e intermitente. Con ellos, y a través de una comparación con los datos oficiales de consumo de otros proyectos, tratamos de hacer una aproximación a la capacidad de los ecosistemas que había exigido el complejo.Con este análisis se plantea cómo con unos números gordos sobre diferentes factores ecosistémicos se puede realizar una primera aproximación sobre la idoneidad (o no) de la adecuación de un proyecto en un territorio y cuáles podrían ser los efectos desde el punto de vista de la sostenibilidad.</p>
El mercado inmobiliario y la producción privada de viviendas: una aproximación a las estrategias empresariales en la ciudad de Córdoba (Argentina)
Authors: Capdevielle Julieta 
Published: July 2016

<p>La primacía dada a los factores estructurales y a la temática de la mundialización en el estudio del cambio urbano dio un énfasis, quizás excesivo, a la definición y a la descripción de la ‘ciudad global’, en detrimento de un estudio de los procesos, los agentes y las prácticas concretas. Para suplir esta carencia, a lo largo de este artículo, se analizan los mecanismos y estrategias concretas de apropiación material y simbólica del espacio urbano que los grupos empresariales ponen en juego. Dentro del conjunto de prácticas se abordan, principalmente las estrategias de unión, las vinculadas al Estado Municipal, las de comercialización y, por último, las de emplazamientos. Posteriormente, se delinean algunas de las consecuencias de las transformaciones urbanas.</p>
Emigración e inmigración internacional en el área metropolitana de Bogotá (Colombia)
Authors: Córdoba Aldana John Harold 
Published: July 2016

<p>El siguiente artículo presenta parte de los resultados de una investigación que relaciona la movilidad internacional con las dinámicas residenciales en Bogotá (Colombia). Tiene como objetivo analizar las dinámicas espaciales de la emigración y la inmigración internacional en la capital colombiana. El estudio está basado en el análisis de los censos de población de 1993 y 2005, así como una encuesta biográfica desarrollada en el programa METAL durante el periodo 2009-2010. El texto es una entrada a la comprensión de las dinámicas residenciales y al cambio urbano, en este caso, desde la migración internacional en el área metropolitana de Bogotá.</p>
El sistema urbano en Colombia y la formación metropolitana: una aproximación desde la Nueva Geografía Económica
Authors: León Nohra , Ruiz Cesar A. 
Published: July 2016

<p>La metropolización se puede entender como un proceso social y económico espacial que suele ocurrir en el marco de sistemas urbanos, por lo que se puede asumir también como un proceso de un subsistema urbano específico. El presente artículo busca, desde este marco, comprender el proceso de metropolización de las principales grandes ciudades colombianas a lo largo de siglo xx y parte del actual. Esta aproximación encuentra, desde la llamada Nueva Geografía Económica, algunas explicaciones válidas. Tres características pueden derivarse de esta visión: formación dinámica de estructuras espaciales, jerarquía urbana y evolución espacio-temporal de la jerarquía. Los cambios del sistema urbano explorados resultan útiles para explicar algunos rasgos de los procesos de metropolización colombiana, así como la dinámica de re-acomodamiento de su concentración urbana.</p>
Competitividad territorial capitalista y despojo del agua en el área de influencia metropolitana de Cali (Colombia)
Authors: Buitrago Bermudez Oscar 
Published: July 2016

<p>Para proponer el concepto de plataforma territorial de competitividad capitalista, se inicia por cuestionar la forma reducida y sesgada de entender el concepto de territorio en el ámbito de la práctica de despojo del agua, en particular, y de la naturaleza, en general. Se plantea el concepto de plataforma territorial de competitividad, entendido como un sistema de territorialidades que articula áreas periféricas al sistema global capitalista, para entender los procesos de expoliación de la naturaleza y el abuso, por parte del Estado y loscapitalistas, sobre las sociedades locales. A partir de este enfoque, se describe el despojo del agua en el marco de las contradicciones del modelo económico capitalista instaurado en Colombia. En el ámbito de la gestión ambiental del agua, la principal evidencia de la presencia de la plataforma territorial de competitividad es la pérdida de institucionalidad ambiental y departamental, la cual facilita la expansión del territorio cañícola.</p>
Defender la capital: el aseguramiento de espacio de dependencia de Bogotá durante el gobierno de Uribe Vélez
Authors: Peña Luis Berneth 
Published: July 2016

<p>Con el desarrollo de enormes operaciones militares durante los gobiernos de Álvaro Uribe (2002-2010), destinadas a expulsar a las organizaciones guerrilleras de las áreas metropolitanas, se puso de presente que la defensa y securización de los espacios de dependencia de las ciudades es un elemento fundamental de la territorialidad del Estado. En este artículo, se analiza el lugar que ocupan estas políticas de seguridad dentro del conjunto de políticas de territoriales del Estado, enfatizando que las estrategias de seguridad no son un ámbito nuevo de intervención política, sino un problema esencial de la formación del Estado. Igualmente, se analiza la red multiescalar de actores que conforman el aseguramiento de la región metropolitana de Bogotá,exponiendo el desarrollo de la operación militar “Libertad Uno”. Con este análisis se busca constituir una línea de investigación sobre las geopolíticas urbanas.</p>
Hospedándose en la ciudad global: patrones de localización de los hoteles de lujo en Santiago de Chile
Authors: Hidalgo Rodrigo , Azar Paula , Borsdorf Axel , Paulsen Alex 
Published: July 2016

<p>Chile se está convirtiendo en uno de los destinos más importantes en América Latina, especialmente, con su capital, Santiago. Así, asume un papel fundamental en los atractivos turísticos de familias, turistas urbanos y de negocios. Estos últimos juegan un rol importante dentro de este contexto, ya que las cadenas internacionales han construido numerosos hoteles de lujo dirigidos a ellos, alcanzando los estándares de las ciudades globales. La continua reestructuración económico-urbana de las metrópolis ha producido una distribución policéntrica de los hoteles de lujo; la mayoría de ellos, los más costosos y ostentosos, se ubican en la ciudad moderna. El aeropuerto, los centros de innovación y parques de negocio, al igual que el centro de la ciudad, también han formado parte de este nicho de inversión. En el caso del área de estudio analizada, las localizaciones de los hoteles de lujo muestran patrones que reflejan una nueva producción del espacio por parte de los agentes privados, en su búsqueda de una mejor capitalización de la renta urbana. Ello se refleja en la estructura intraurbana de los precios y la distribución de los hoteles de lujo.</p>
Location of Primary Tumor and Benefit From Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies in Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer
Authors: Moretto Roberto , Cremolini Chiara , Rossini Daniele , Pietrantonio Filippo , Battaglin Francesca , Mennitto Alessia , Bergamo Francesca , Loupakis Fotios , Marmorino Federica , Berenato Rosa , Marsico Valentina Angela , Caporale Marta , Antoniotti Carlotta , Masi Gianluca , Salvatore Lisa , Borelli Beatrice , Fontanini Gabriella , Lonardi Sara , De Braud Filippo , Falcone Alfredo 
Published: July 2016

Abstract

Introduction.
Right- and left-sided colorectal cancers (CRCs) differ in clinical and molecular characteristics. Some retrospective analyses suggested that patients with right-sided tumors derive less benefit from anti-epidermal growth factor receptor (EGFR) antibodies; however, molecular selection in those studies was not extensive.

Patients and Methods.
Patients with RAS and BRAF wild-type metastatic CRC (mCRC) who were treated with single-agent anti-EGFRs or with cetuximab-irinotecan (if refractory to previous irinotecan) were included in the study. Differences in outcome between patients with right- and left-sided tumors were investigated.

Results.
Of 75 patients, 14 and 61 had right- and left-sided tumors, respectively. None of the right-sided tumors responded according to RECIST, compared with 24 left-sided tumors (overall response rate: 0% vs. 41%; p = .0032), and only 2 patients with right-sided tumors (15%) versus 47 patients with left-sided tumors (80%) achieved disease control (p &lt; .0001). The median duration of progression-free survival was 2.3 and 6.6 months in patients with right-sided and left-sided tumors, respectively (hazard ratio: 3.97; 95% confidence interval: 2.09–7.53; p &lt; .0001).

Conclusion.
Patients with right-sided RAS and BRAF wild-type mCRC seemed to derive no benefit from single-agent anti-EGFRs.