bluuebunny/crossref_metadata_2025_split huggingface dataset:
A description of clinical profile of over 65-years-old patients in acute psychiatric hospitalization unit at Hospital Universitario Central De Asturias (Oviedo, Spain)
Authors: Abad-Acebedo I. , Gonzalez-Blanco L. , Torio-Ojea E. , Bestene-Medina S. , Rodriguez-Revuelta J. 
Published: May 2016

IntroductionOlder patients with psychiatric conditions often have other disorders that include different levels of cognitive impairment, modifying the presentation of psychiatric symptoms and requiring treatment adaptations [1].ObjectiveTo describe clinical profile of hospitalized patients > 65 years, and its relationship with the presence of cognitive impairment and the length of hospital stay.MethodsDescriptive and comparative study. Sample: 71 inpatients > 65 years (mean ± SD Age: 72.42 ± 5.96), admitted to “Hospital Universitario Central de Asturias”(Spain) from August 2014 to June 2015. Age, length of hospitalization, diagnosis, cognitive impairment and treatment data were collected (Table 1).ResultsDays of hospital stay (mean ± SD) = 15.89 ± 11.53. No variable showed significant relation except number of antipsychotics taken (r = 0.307, P = 0.009). Cognitive impairment was significantly more frequent in men than women (45.5/15.8%; χ2 = 7.46; P = 0.006). No other variable showed significant differences.ConclusionsA high percentage of psychiatric inpatients > 65 years present a cognitive impairment (29.6%) which was more frequent in males (45.5%). The length of hospital stay seems to be similar than in the rest of patients and not being affected by any of studied variables. More studies should be carried on to compare those results with similar variables in younger population and to analyze if there are differences between subgroups (65–75 vs > 75) [1].Disclosure of interestThe authors have not supplied their declaration of competing interest.
Burden of informal carers in northwest Ireland: A pilot study of factors that influence burden
Authors: McCarthy G. , Gresswell I. , Adamis D. 
Published: May 2016

IntroductionResearch has shown that approximately 67% of carers experience extreme mental tiredness, a decrease in their quality of life and a deterioration in their physical health since taking on a care-giving role.Aims and objectivesThis study aims to identify factors that influence carer burden and in doing so, identify the sub-populations of carers who are most susceptible to burden.MethodsIn northwest Ireland, 53 informal carers referred to the Carers Association, Sligo were contacted and met for a face-to-face interview. Measurements used included demographic data, the Neuropsychiatric Inventory, Zarit Burden Interview, Social Network Index and Brown's Locus of Control Scale.ResultsOf the 53 carers, 43 were females and 10 males (age range: 32–81 years, mean age of 64.5 years). Of the corresponding 53 patients, 21 were females and 32 males (age range: 17–92 years, mean age of 72.1 years). Multiple linear regression analysis showed that sex of carer, marital status and the patient's behavioural problems were statistically significant independent factors, which influenced carer burden (p < 0.01). Female sex and greater patient behavioural problems increased susceptibility to burden and being married increased resilience towards burden.ConclusionsThe ability to predict which carers are more susceptible to burden allows physicians to more quickly identify “higher risk” carers, facilitating routine check-ups by physicians and carer support services. Further research should explore why female and unmarried carers are more susceptible to burden and whether it is possible to tailor support services to their individual needs.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Religiosity and its influence on mental health of late age persons
Authors: Pishchikova L. 
Published: May 2016

Christian anthropology considers personality as a unity of spiritual, emotional and corporal manifestation. Spirituality is defined as highest level of development and self-control of mature personality, ignoring which leads to moral dissonance and spiritual conflict. For the believing person, it is indisputable that belief, church sacraments and practices are capable to facilitate not only corporal, but also spiritual diseases. Clinical and expert analysis of 235 late age patients (> 60 years), who underwent forensic psychiatric examination in criminal and civil cases, helped to identify the influence of religiosity on mental health of late age persons. At late age, appeal to spirituality defines further evolutionary development of the person and favorable forms of aging. It is noted that elderly believers have no expressed cognitive and emotional frustration. When developing mental disorders, they resort to church sacraments and prayers. Thus, a patient with visual hallucinosis noted that during a prayer “visions calmed down, left or started listening”. A patient with acoustical hallucinosis (“blasphemous” voices) considered them as manifestation of “dark powers”, fought them by appeal to the icon of the Mother of God. A patient with menacing acoustical hallucinations read Psalmbook, dawned on them a cross sign with “consecrated hand” (venerated to Sacred relics) and “locked” them in room corner. Ignoring spirituality, which is observed in psychiatry, is connected with incompatibility of representations based on science and belief; low level of religiousness among psychiatrists; underestimation of religion role in life of patients; lack of special knowledge of this area.Disclosure of interestThe author has not supplied his/her declaration of competing interest.
Depression and mild cognitive impairment – Comorbidity and/or continuum?
Authors: Sobreira G. , Aleixo M.A. , Moreia C. , Oliveira J. 
Published: May 2016

IntroductionDepression and mild cognitive impairment are common among the elderly. Half the patients with late-life depression also present some degree of cognitive decline, making the distinction between these conditions difficult.ObjectivesTo conduct a database review in order to understand the relationship between these entities, and treatment approaches.AimsTo create and implement clinical guidelines at our institution, to evaluate and treat elderly patients presenting with depression and mild cognitive impairment.MethodsA PubMed database search using as keywords “late life depression”, “depression”; “cognitive impairment”; “mild cognitive impairment” and “dementia” between the year 2008 and 2015.ResultsLate-life depression and cognitive impairment are frequent among the elderly (10–20%). Depression is also common in the early stages of dementia decreasing as the cognitive decline progresses. The causal relationship between these entities is not well understood and some authors advocate a multifactorial model (genetic risk factors; neuroendocrine changes; vascular risk factors) and the cognitive impairment of said changes is dependent on the individual's cognitive reserve. Regarding treatment of depression in patients with cognitive impairment, most authors advocate a stepped approach with watchful waiting and then, if symptoms persist, the introduction of pharmacotherapy and psychosocial intervention.ConclusionsThe relationship between cognitive impairment and depression is still not clear and probably multifactorial. The diagnosis of depressive symptoms in patients with severe cognitive impairment can be difficult and most forms of pharmacological treatment in this population are not beneficial, making it important to carefully evaluate the benefits of introducing new medication.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Anosognosia in dementia – Relevance for clinical-practice in a memory clinic
Authors: Verhülsdonk S. , Höft B. , Supprian T. , Lange-Asschenfeldt C. 
Published: May 2016

IntroductionAnosognosia is a common symptom in patients with dementia, although data on prevalence vary widely. It is associated with decreased compliance to medical diagnosis and treatment. The rejection of assistance challenges professionals as well as caring relatives.ObjectivesAnosognosia increases with progression of disease but is also found in early stages. The underlying mechanisms are not completely understood; past studies described an association with executive dysfunction.AimsOur study aims to identify the frequency of anosognosia in our memory clinic.MethodsWe evaluated disease awareness using the Clinical Insight Rating Scale in 124 patients presenting with diagnosis of Alzheimer's disease in our memory clinic. We correlated the degree of awareness with standardized cognitive, affective, and functional parameters.ResultsOne hundred and fourteen patients (90.9%) showed decreased awareness, in 51.7% of our sample awareness was seriously impaired or even entirely lacking. In accordance with the literature, anosognosia correlated significantly with the result of the Mini-Mental-Staus-Examination as indicator of global cognitive functioning (r = −0.291, P < 0.05) and with the need for assistance in everyday-life (r = .364, P < 0.05). We found no correlation with depressive symptoms or age.ConclusionThe phenomenon of anosognosia is frequent in the setting of a memory clinic and has special impact on clinical practice as it is well correlated with executive functioning and global cognition and, thus, is a relevant factor for the initiation of medical care for patients with dementia.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Family burden and quality of life of mothers of children and adolescents with mental retardation or borderline mental capacity
Authors: Utas Akhan L. 
Published: May 2016

IntroductionStudies have found that the cognitive function levels of intellectually challenged children add a burden to the family and affect quality of life.ObjectivesThe purpose of this study was to determine the family burden felt by mothers of children, ages 6–16, whose mental capacity evaluation indicates an IQ of 35–79 to explore the mother's quality of life and discover the factors that yield an impact in this context.AimsThe main objective of this study therefore was to ascertain the family burden and quality of life experienced by the parents of children with mentally retarded or borderline mental capacity.MethodsThe WISC-R test was used in the research to determine the intellectual capacity of children, 6–16 years of age. The sample comprised 131 children and adolescents between the ages 6–16 with IQs in the interval of 35–79 and their mothers. The parents accompanying their children were assessed using the Family Burden Assessment Scale, the World Health Organization Quality of Life instrument and a sociodemographic questionnaire that was filled out during face-to-face interviews.ResultsThe quality of life of the mothers was found to be average. At the same time, as the IQ level of the children went up, the less the mothers felt they were under a family burden. It was seen that the mothers experienced the most difficulty in the domains of “perception of inadequacy” and “emotional burden.”ConclusionMothers with intellectually disabled children need psychosocial support. Providing all members of the family with counseling services to help them cope with the issues and responsibilities involved in the care of disabled children may make a significant difference in quality of life.Disclosure of interestThe author has not supplied his/her declaration of competing interest.
Elderly person's connection of family relations with quality of life and shame in the context primary healthcare
Authors: Kotrotsiou E. , Mparka I. , Xatzoglou C. , Gouva M. 
Published: May 2016

ObjectivesThe elderly persons continue to invest substantially in emotional relationships.AimThe overall objective of this research study was to investigate the attitudes of elderly persons towards family relations.MethodOne hundred and ninety-seven healthy elderly individuals participated to the present study from different region in Greece. The age range was 66–93 years old. The questionnaire included: (a) the Family Environment Scale (Family Environment Scale, Form R-FES), (b) The Experience of Shame Scale (ESS), (c) the Other As Shamer Scale (OAS), (d) Quality of Life (SF-36).ResultsUnivariate and multivariate analysis was applied for the statistical analysis of the data, which showed that: the elderly persons who are satisfied with their lives in past, they exhibit lower overall price external shame feelings of emptiness (empty – OAS) (P = .002), they perceived reaction of others when they make mistakes (Mistakes – OAS) (P = .000), conflict (Conflict – [Form R-FES]) (P = .000). Elderly persons who are satisfied with their life in this time show higher levels of orientation towards active recreational activity (Active-Recreational Orientation – R-FES) (P = .000). Elderly persons who declared that family relation is important for them exhibit lower levels of feeling vacuum (empty – OAS) (P = .009), and higher levels of orientation for achievements (Achievement Orientation) (R-FES) (P = .010), social role (SF – SF36) (P = .000), Mental Health summary Scale (SF_MCS-SF36) (P = .000).ConclusionFrom the findings of this study, it is apparent how important is the study of the quality of life in old age.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Implication of altered α7 nicotinic receptors and amyloid deposition in the Alzheimer's brain
Authors: Nakaizumi K. , Terada T. , Yoshikawa E. , Kakimoto A. , Takashi I. , Suzuki I. , Tomoyasu B. , Suzuki K. , Magata Y. , Mori N. , Ouchi Y. 
Published: May 2016

IntroductionBrain amyloid-β protein (Aβ) deposition is a key pathology of Alzheimer's disease (AD). Cholinergic degeneration, including reductions in α7 nicotinic acetylcholine receptors (α7-nAChR), is also known as a pathophysiology of AD. Recent imaging studies have shown cognitively normal subjects with Aβ depositions, indicating a missing link between Aβ deposition and cognitive decline.ObjectivesTo clarify relationships among the Aβ burden, α7-nAChR availability, and cognitive declines in AD.AimsTo measure brain Aβ deposition and α7-nAChR availability in the same patients with AD using positron emission tomography (PET).MethodsTwenty AD patients and age-matched 20 healthy adults were studied. The α7-nAChR availability and Aβ deposition were evaluated using PET with [11C]MeQAA and [11C]PIB, respectively. Levels of specific binding were estimated by a simplified reference tissue method (BPND) for [11C]MeQAA and a tissue ratio method (SUVR) for using [11C]PIB. The values were compared with clinical measures of various cognitive functions using regions of interest (ROIs)-based and statistical parametric mapping (SPM) analyses.Results[11C]MeQAA BPND levels were extensively lower in the cholinergic projection regions of AD. There was a significant negative correlation between [11C]PIB SUVR and [11C]MeQAA BPND in the nucleus basalis of Mynert (NBM). The NBM [11C]PIB SUVR was negatively correlated with the [11C]MeQAA BPND level in the anterior and posterior cingulate cortices, whereas the relation within the same region showed weak correlation. Also we found significant correlation between cognitive decline and [11C]MeQAA BPND levels in the NBM.ConclusionsAβ deposition-linked α7-nAChR dysfunction may account for cognitive decline in AD.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Cognitive behavioral therapy in pharmacoresistant obsessive-compulsive disorder
Authors: Vyskocilova J. , Prasko J. 
Published: May 2016

BackgroundThe aim of the study was to determine whether patients with OCD resistant to drugs may improve using intensive, systematic CBT lasting six weeks and whether it is possible to predict the therapeutic effect using demographic, clinical and psychological characteristics at baseline.MethodThere were 66 patients included in the study. Fifty-seven patients completed the program. The diagnosis was confirmed by a structured interview MINI. Patient were rated before the treatment using Y-BOCS (objective and subjective form), CGI (objective and subjective form), BAI, BDI, DES (Dissociative Experiences Scale), SDQ 20 (Somatoform Dissociation Questionnaire), and SDS (Sheehan Disability Scale), and at the end of the treatment using subjective Y-BOCS, objective and subjective CGI, BAI, and BDI. Patients were treated with antidepressants and daily intensive group cognitive behavioral therapy for the period of six weeks.ResultsDuring the 6-week intensive cognitive behavioral therapy program in combination with pharmacotherapy, there was a significant improvement in patients suffering from OCD formerly resistant to pharmacotherapy. There were statistically significant decreases in the scales assessing the severity of OCD symptoms, anxiety, and depressive feelings. The lower treatment effect was achieved specifically in patients who:– showed fewer OCD themes in symptomatology;– showed a higher level of somatoform dissociation;– with poor insight;– with a higher level of overall severity of the disorder in the beginning.The remission of the disorder was achieved more probably in patients with:– good insight;– the lower level of initial anxiety;– without comorbidity with the depressive disorder.Disclosure of interestThe authors have not supplied their declaration of competing interest.
The risk of sleep disorders in Korean cancer patients
Authors: Lee H. , Oh S.T. , Kim D.W. , Choi W.J. 
Published: May 2016

PurposeSleep disturbance in cancer patients is common. The aim of this study is to investigate the risk of sleep disorders in cancer patients compared to patients with other diseases using the national registry data.MethodUsing data from the Korean National Health Insurance Research Database between 2002 and 2013, the cancer group was composed of patients with an initial diagnosis of cancer in 2004 (n = 3358). The remaining people were considered as comparison group (n = 493,577) after excluding patients with any cancer or psychiatric disorder from 2002 to 2003 and from 2005 to 2013. Each sampled subject was tracked until 2013. Cox proportional hazard regressions were used to calculate the overall rate for sleep disorder development after adjusting for age, gender, and socio-economical confounders.ResultsCancer patients were associated with an increased risk of sleep disorder in both sexes (male hazard ratio [HR]: 1.319; 95% confidence interval [CI]: 1.232–1.413; female HR: 1.289; 95% CI: 1.198–1.386) after adjusting for potential confounders. Both results were statistically significant (P < 0.001). In terms of age, the effect size of the HR was largest among elder adults, aged ≥ 70 years (male HR: 1.748; female HR: 1.820). The HR tended to increase consistently.ConclusionInitial diagnosis of cancer was significantly associated with sleep disorder development after adjusting for potential confounders. This result suggests that thorough screening and intervention for sleep disorders are required for the newly diagnosed cancer patients to improve their quality of life.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Interdisciplinary rehabilitation of a patient with right brain injury and recurrent depression
Authors: Varako N. , Dobrushina O. , Zinchenko Y. , Martynov S. , Kovyazina M. 
Published: May 2016

IntroductionRehabilitaton of concurrent psychiatric disorder and brain injury is a major challenge. E. underwent neurosurgery for right fronto-parietal astrocytoma. Before illness he was managing automatization of big companies, but was fired after the operation. E. felt into severe depression and anxiety with catastrofization of his illness, suicidal ideation. He resisted multiple prescriptions for SSRI, admitting a sect pretending to “treat” oncology by “psychological” methods. Half a year after operation he attended our center.Objectives and aimTo help E. return to paid employment.MethodsE. was evaluated by neurologists, psychiatrist, neuropsychologists. Current depressive episode appeared to be the second one with underlying schizoid and perfectionist characteristics. He had moderate text comprehension difficulties, confabulations, slight executive dysfunction. Neuropsychologist educated patient on his difficulties and developed compensatory strategies – an alternative to catastrofisation. After psychoeducational session E. agreed to receive fluvoxamine. However, he deformed the received information due to brain injury, so psychotherapy had only minor effects. Infra-low frequency neurofeedback at T4P4 and T4Fp2 sites was started to promote restoration of right brain functions. E. gradually did better, and 3 months later was able to complete CBT course along with relaxation training.ResultsImprovements in emotional status along with ability to cope with cognitive difficulties allowed E. to return to a job similar to the previous. Six month after the start of treatment medications are tapered off, E. has no signs of depression and only slight anxiety.ConclusionsInterdisciplinary holistic rehabilitation may be effective in concurrent psychiatric disorder and brain injury.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Chronic non-malignant pain (CNMP) and substance use disorders
Authors: Herrera Duran L. , Falgas I. , Cook B. , Noyola N. , Toro M. , Alegria M. 
Published: May 2016

IntroductionChronic non-malignant pain (CNMP) is defined as pain lasting a minimum of three months. In general, chronic pain affects 20% adult worldwide population. Moreover, pain is more common in patients with depression, anxiety, and substance-use disorders and with low socioeconomic status. We aimed to better understand the influence of pain on substance use and treatment use patterns of individuals who experienced clinically recognized pain and have substance use disorder.MethodsPatients with pain disturbances were identified in Electronic Health Records (EHR) through ICD-9 code 338*, medical written diagnoses, or diagnoses of fibromyalgia. A patient was considered to have a substance use disorder if he received treatment for illicit drug or alcohol abuse or dependence. We combined 2010–2012 (EHR) data from primary care and specialty mental health setting in a Boston healthcare system (n = 131,966 person-years) and a specialty mental health care setting in Madrid, Spain (n = 43,309 person-years).ResultsWe identified that 35.3% of individuals with clinically recognized pain also report substance use disorder, compared to only 10.6% of individuals without clinically recognized pain (P < 0.01). Those with co-morbid pain and substance use disorder were significantly more likely than their specialty care counterparts without co-morbid pain and substance disorders to be seen in the emergency room (56.5% vs. 36.6%, respectively, P < 0.01).ConclusionThe findings suggest that CNMP is associated with an increase risk of substance abuse disorder.Disclosure of interestThe authors have not supplied their declaration of competing interest.