bluuebunny/crossref_metadata_2025_split huggingface dataset:
The utility of adaptive eLearning in cervical cytopathology education
Authors: Samulski T. Danielle , Taylor Laura A. , La Teresa , Mehr Chelsea R. , McGrath Cindy M. , Wu Roseann I. 
Published: October 2017

BACKGROUNDAdaptive eLearning allows students to experience a self‐paced, individualized curriculum based on prior knowledge and learning ability.METHODSThe authors investigated the effectiveness of adaptive online modules in teaching cervical cytopathology. eLearning modules were created that covered basic concepts in cervical cytopathology, including artifacts and infections, squamous lesions (SL), and glandular lesions (GL). The modules used student responses to individualize the educational curriculum and provide real‐time feedback. Pathology trainees and faculty from the authors' institution were randomized into 2 groups (SL or GL), and identical pre‐tests and post‐tests were used to compare the efficacy of eLearning modules versus traditional study methods (textbooks and slide sets). User experience was assessed with a Likert scale and free‐text responses.RESULTSSixteen of 17 participants completed the SL module, and 19 of 19 completed the GL module. Participants in both groups had improved post‐test scores for content in the adaptive eLearning module. Users indicated that the module was effective in presenting content and concepts (Likert scale [from 1 to 5], 4.3 of 5.0), was an efficient and convenient way to review the material (Likert scale, 4.4 of 5.0), and was more engaging than lectures and texts (Likert scale, 4.6 of 5.0). Users favored the immediate feedback and interactivity of the module. Limitations included the inability to review prior content and slow upload time for images. Learners demonstrated improvement in their knowledge after the use of adaptive eLearning modules compared with traditional methods.CONCLUSIONSOverall, the modules were viewed positively by participants. Adaptive eLearning modules can provide an engaging and effective adjunct to traditional teaching methods in cervical cytopathology. Cancer Cytopathol 2018;126:129‐35. © 2017 American Cancer Society.
Sustainable Development and Competitive Advantages – Utilizing Matching to Overcome Sample Selection Bias
Authors: Teng Mei‐Jane , Wu Shih‐Ying 
Published: October 2017

AbstractThis study investigates whether a firm can enhance its competitive advantages in intangible assets and financial performance by voluntarily obtaining the certification of environmental management system ISO 14001. Previous studies find mixed evidence for the effect of ISO 14001 certification on firm performance partly owing to sample selection bias. To overcome this bias, we utilize propensity score matching to find non‐certified firms that are comparable to certified firms. The evidence from our matching method suggests that ISO 14001 certified firms have higher values of intangible assets than non‐certified firms. Our study thus suggests that stakeholder engagement in firms' environmental management can be beneficial not only to the public, but also to shareholders. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Structure–Activity and Stability Relationships for Cobalt Polypyridyl‐Based Hydrogen‐Evolving Catalysts in Water
Authors: Schnidrig Stephan , Bachmann Cyril , Müller Peter , Weder Nicola , Spingler Bernhard , Joliat‐Wick Evelyne , Mosberger Mathias , Windisch Johannes , Alberto Roger , Probst Benjamin 
Published: October 2017

AbstractA series of eight new and three known cobalt polypyridyl‐based hydrogen‐evolving catalysts (HECs) with distinct electronic and structural differences are benchmarked in photocatalytic runs in water. Methylene‐bridged bis‐bipyridyl is the preferred scaffold, both in terms of stability and rate. For a cobalt complex of the tetradentate methanol‐bridged bispyridyl–bipyridyl complex [CoIIBr(tpy)]Br, a detailed mechanistic picture is obtained by combining electrochemistry, spectroscopy, and photocatalysis. In the acidic branch, a proton‐coupled electron transfer, assigned to formation of CoIII−H, is found upon reduction of CoII, in line with a pKa(CoIII−H) of approximately 7.25. Subsequent reduction (−0.94 V vs. NHE) and protonation close the catalytic cycle. Methoxy substitution on the bipyridyl scaffold results in the expected cathodic shift of the reduction, but fails to change the pKa(CoIII−H). An analysis of the outcome of the benchmarking in view of this postulated mechanism is given along with an outlook for design criteria for new generations of catalysts.
Dipeptidyl peptidase 4 inhibitors attenuates the decline of skeletal muscle mass in patients with type 2 diabetes
Authors: Bouchi Ryotaro , Fukuda Tatsuya , Takeuchi Takato , Nakano Yujiro , Murakami Masanori , Minami Isao , Izumiyama Hajime , Hashimoto Koshi , Yoshimoto Takanobu , Ogawa Yoshihiro 
Published: October 2017

AbstractBackgroundActivation of dipeptidyl peptidase 4 has been reported to be associated with impairment of insulin signalling in skeletal muscle, presumably leading to loss of muscle function. This study was aimed to investigate whether the use of dipeptidyl peptidase 4 inhibitors (DPP4i) could attenuate the progressive loss of muscle mass in patients with type 2 diabetes.MethodsA total 105 patients with type 2 diabetes (mean age 62 ± 12 years; 39% female) were studied in this retrospective observational study. To reduce the bias due to confounding variables, propensity‐score matching analysis was performed. Change in skeletal muscle index measured by the whole body dual‐energy X‐ray absorptiometry at 1‐year follow‐up was evaluated. One‐year changes in visceral and subcutaneous fat area and liver attenuation index were also determined by abdominal computed tomography.ResultsOverall, 37 of 105 (35.2%) patients were treated with DPP4i. The estimated change in skeletal muscle index in patients with DPP4i was significantly higher than that in patients without (0.05 ± 0.06 vs −0.10 ± 0.04 kg, P = .046). In a propensity‐matched population (N = 48), the same finding was observed (0.04 ± 0.03 in DPP4i versus −0.12 ± 0.03 kg in non‐DPP4i, P = .033). There were no significant differences in changes of visceral and subcutaneous fat area and liver attenuation index between patients with DPP4i and those without.ConclusionsOur data suggest the potential of DPP4i to prevent the progressive loss of muscle mass with ageing in patients with type 2 diabetes.
Model application niche analysis: assessing the transferability and generalizability of ecological models
Authors: Moon Jessica B. , Dewitt Theodore H. , Errend Melissa N. , Bruins Randall J. F. , Kentula Mary E. , Chamberlain Sarah J. , Fennessy M. Siobhan , Naithani Kusum J. 
Published: October 2017

AbstractThe use of models by ecologists and environmental managers, to inform environmental management and decision‐making, has grown exponentially in the past 50 yr. Due to logistical, economical, and theoretical benefits, model users frequently transfer preexisting models to new sites where data are scarce. Modelers have made significant progress in understanding how to improve model generalizability during model development. However, models are always imperfect representations of systems and are constrained by the contextual frameworks used during their development. Thus, model users need better ways to evaluate the possibility of unintentional misapplication when transferring models to new sites. We propose a method of describing a model's application niche for use during the model selection process. Using this method, model users synthesize information from databases, past studies, and/or past model transfers to create model performance curves and heat maps. We demonstrated this method using an empirical model developed to predict the ecological condition of plant communities in riverine wetlands of the Appalachian Highland physiographic region, USA. We assessed this model's transferability and generalizability across (1) riverine wetlands in the contiguous United States, (2) wetland types in the Appalachian Highland physiographic region, and (3) wetland types in the contiguous United States. With this methodology and a discussion of its critical steps, we set the stage for further inquiries into the development of consistent and transparent practices for model selection when transferring a model.
Effective Installation Strategies of Fault Current Interrupting Arcing Horns Considering Operational Coordination with Responses of Line Protection Relays
Authors: OHTAKA TOSHIYA , KAMEDA HIDEYUKI 
Published: October 2017

SUMMARYThe Fault Current Interrupting Arcing Horns (FCIAH) is a new type of arcing horns, which operates to break fault current within one cycle of alternating current and contributes to reducing the instantaneous power interruption due to the opening of a circuit breaker. However, reportedly the transmission line is often tripped by the line protection relay in some power utilities, even though the FCIAH successfully could break fault current. In this paper, we have investigated primary factors in the unwanted operation of the line protection relays at the current interruption by the FCIAH, and have proposed effective installation strategies of the FCIAH considering the operational coordination with the responses of the line protection relays.
Pressure Rises Due to Arc under Insulating Oil in Closed Vessel—Pressure Fluctuation of Depth Direction in Oil
Authors: TADOKORO TOMO , KOTARI MASASHI , OHTAKA TOSHIYA , IWATA MIKIMASA , AMAKAWA TADASHI 
Published: October 2017

SUMMARYWhen a fault arc occurs in oil‐filled electric equipment, it generates a flammable gas and a dynamic pressure rise. In this study, the pressure rises due to the arc are measured in a closed vessel containing air and oil for different arc depths. The pressure rises in air and oil with different depth are measured under experimental conditions involving an arc current 6.6 kA, an arc duration of 100 ms. Experimental results show that the frequency of pressure fluctuation varies with the depth of the arc. Our approximate calculation of the pressure fluctuation with consideration of the oil flux is consistent with the experimental results.
Mapping Complexity in Environmental Governance: A comparative analysis of 37 priority issues in German water management
Authors: Kirschke Sabrina , Borchardt Dietrich , Newig Jens 
Published: October 2017

AbstractEnvironmental governance regularly has to cope with complex problems. However, ‘complexity’ has mostly been used as a heuristic concept and hardly made operable for empirical research. Drawing on psychological research on complex problem solving, we propose a structured operationalization of complexity in the five dimensions of (1) goals, (2) variables, (3) dynamics, (4) interconnectedness and (5) information uncertainty. Based on 65 semi‐standardized expert interviews and 158 assessments of complexity degrees, we analyse and map 37 water‐related problems in Germany with regard to their complexity. We find that these problems tend to exhibit medium degrees of complexity, based on 30 types of argument for complexity. Our analysis also reveals varying degrees of complexity and delineates the various natural, technical and social sources of complexity. Our approach and the results may facilitate more systematic discussion of governance strategies for complex problem solving across environmental policy fields and scales. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Challenges of Rasthryia Swasthya Bima Yojana (RSBY) in West Bengal, India: An exploratory study
Authors: Bandyopadhyay Satarupa , Sen Kasturi 
Published: October 2017

SummaryThis study reviews the economic viability of the Rashtriya Swasthya Bima Yojana (RSBY), India's landmark health insurance program for below poverty line (BPL) populations in West Bengal state of India. It addresses the issue through in‐depth analysis of literature, national and state level data, and a number of key stakeholder interviews. The study argues that the market failure conditions of this insurance model will continue to perpetuate losses for not only the state, but also for insurance companies, unless they adjust on a continuous basis for profit by raising the premium rate. This will further deplete state budgets for health care affecting the viability of the scheme in the long run.
Protein/polysaccharide‐based scaffolds mimicking native extracellular matrix for cardiac tissue engineering applications
Authors: Rosellini Elisabetta , Zhang Yu Shrike , Migliori Bianca , Barbani Niccoletta , Lazzeri Luigi , Shin Su Ryon , Dokmeci Mehmet Remzi , Cascone Maria Grazia 
Published: October 2017

AbstractTissue engineering has emerged as a viable approach to treat disease or repair damage in tissues and organs. One of the key elements for the success of tissue engineering is the use of a scaffold serving as artificial extracellular matrix (ECM). The ECM hosts the cells and improves their survival, proliferation, and differentiation, enabling the formation of new tissue. Here, we propose the development of a class of protein/polysaccharide‐based porous scaffolds for use as ECM substitutes in cardiac tissue engineering. Scaffolds based on blends of a protein component, collagen or gelatin, with a polysaccharide component, alginate, were produced by freeze‐drying and subsequent ionic and chemical crosslinking. Their morphological, physicochemical, and mechanical properties were determined and compared with those of natural porcine myocardium. We demonstrated that our scaffolds possessed highly porous and interconnected structures, and the chemical homogeneity of the natural ECM was well reproduced in both types of scaffolds. Furthermore, the alginate/gelatin (AG) scaffolds better mimicked the native tissue in terms of interactions between components and protein secondary structure, and in terms of swelling behavior. The AG scaffolds also showed superior mechanical properties for the desired application and supported better adhesion, growth, and differentiation of myoblasts under static conditions. The AG scaffolds were subsequently used for culturing neonatal rat cardiomyocytes, where high viability of the resulting cardiac constructs was observed under dynamic flow culture in a microfluidic bioreactor. We therefore propose our protein/polysaccharide scaffolds as a viable ECM substitute for applications in cardiac tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 769–781, 2018.
Effect of functionalized PHEMA micro‐ and nano‐particles on the viscoelastic properties of fibrin–agarose biomaterials
Authors: Scionti Giuseppe , Rodriguez‐Arco Laura , Lopez‐Lopez Modesto T. , Medina‐Castillo Antonio L. , Garzón Ingrid , Alaminos Miguel , Toledano Manuel , Osorio Raquel 
Published: October 2017

AbstractTwo types of PHEMA‐based particles, exhibiting either carboxyl or tertiary ammine functional groups, were incorporated to fibrin–agarose (FA) hydrogels, and the effect of the addition of these synthetic particles on the viscoelastic and microstructural properties of the biomaterials was evaluated. Experimental results indicated that the incorporation of both types of polymeric particles to FA scaffolds was able to improve the biomechanical properties of the biomaterials under steady state and oscillatory shear stresses, resulting in scaffolds characterized by higher values of the storage, loss, and shear moduli. In addition, the microstructural evaluation of the scaffolds showed that the nanoparticles exhibiting carboxyl functional groups were homogeneously distributed across the fibrous network of the hydrogels. The addition of both types of artificial polymeric particles was able to enhance the viscoelastic properties of the FA hydrogels, allowing the biomaterials to reach levels of mechanical consistency under shear stresses in the same range of some human native soft tissues, which could allow these biomaterials to be used as scaffolds for new tissue engineering applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 738–745, 2018.
Magnetic stimulus responsive vancomycin drug delivery system based on chitosan microbeads embedded with magnetic nanoparticles
Authors: Mohapatra Ankita , Harris Michael A. , LeVine David , Ghimire Madhav , Jennings Jessica A. , Morshed Bashir I. , Haggard Warren O. , Bumgardner Joel D. , Mishra Sanjay R. , Fujiwara Tomoko 
Published: October 2017

AbstractLocal antibiotic delivery can overcome some of the shortcomings of systemic therapy, such as low local concentrations and delivery to avascular sites. A localized drug delivery system (DDS), ideally, could also use external stimuli to modulate the normal drug release profile from the DDS to provide efficacious drug administration and flexibility to healthcare providers. To achieve this objective, chitosan microbeads embedded with magnetic nanoparticles were loaded with the antibiotic vancomycin and stimulated by a high frequency alternating magnetic field. Three such stimulation sessions separated by 1.5 h were applied to each test sample. The chromatographic analysis of the supernatant from these stimulated samples showed more than approximately 200% higher release of vancomycin from the DDS after the stimulation periods compared to nonstimulated samples. A 16‐day long term elution study was also conducted where the DDS was allowed to elute drug through normal diffusion over a period of 11 days and stimulated on day 12 and day 15, when vancomycin level had dropped below therapeutic levels. Magnetic stimulation boosted elution of test groups above minimum inhibitory concentration (MIC), as compared to control groups (with no stimulation) which remained below MIC. The drug release from test groups in the intervals where no stimulation was given showed similar elution behavior to control groups. These results indicate promising possibilities of controlled drug release using magnetic excitation from a biopolymer‐based DDS. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2169–2176, 2018.
Critical‐sized full‐thickness skin defect regeneration using ovine small intestinal submucosa with or without mesenchymal stem cells in rat model
Authors: Rashtbar Morteza , Hadjati Jamshid , Ai Jafar , Shirian Sadegh , Jahanzad Issa , Azami Mahmoud , Asadpuor Shiva , Sadroddiny Esmaeil 
Published: October 2017

AbstractDecellularized extracellular matrices (ECM) based materials are routinely used for a variety of clinical applications. Hereof, in vivo application of decellularized ovine small intestinal submucosal (DOSIS) layer as, a scaffold is yet to be investigated. In this study, the effectiveness of the DOSIS scaffold, with or without rat bone marrow mesenchymal stem cells (BM‐MSCs), in full‐thickness wound healing of critical‐sized defect was experimentally studied in a rat model. The experimental groups included; group I (control), group II (DOSIS), and group III (BM‐MSCs‐seeded DOSIS). Wound healing of all groups was examined and compared clinically and histopathologically on days 7, 14, and 21 postoperation. Our results represented BM‐MSCs‐seeded DOSIS accelerated wound contraction and healing compared to both the DOSIS alone and control groups. Epithelization was close to completion 21 days postoperation in DOSIS alone. In OSIS with BM‐MSCs group, epithelization was faster and had fully taken place at the subsequent time points. DOSIS layer, as cell‐free form with low substantially DNA content, accelerated healing of rat skin wound defects that was created at critical‐size and full‐thickness. In conclusion, decellularized OSIS alone and in combination with BM‐MSCs has the potential to be used as a wound graft material in skin regenerative medicine. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2177–2190, 2018.
Short‐term hypoxia upregulated Mas receptor expression to repress the AT1R signaling pathway and attenuate Ang II‐induced cardiomyocyte apoptosis
Authors: Chang Ruey‐Lin , Chang Chih‐Fen , Ju Da‐Tong , Ho Tsung‐Jung , Chang Tung‐Ti , Lin Jing‐Wei , Li Jia‐Chun , Cheng Shiu‐Min , Day Cecilia‐Hsuan , Viswanadha Vijaya Padma , Huang Chih‐Yang 
Published: October 2017

AbstractHypertension‐stimulated cardiac hypertrophy and apoptosis play critical roles in the progression of heart failure. Our previous study suggested that hypertensive angiotensin II (Ang II) enhanced insulin‐like growth factor receptor II (IGF‐IIR) expression and cardiomyocyte apoptosis, which are involved JNK activation, sirtuin1 (SIRT1) degradation, and heat‐shock transcription factor 1 (HSF1) acetylation. Moreover, previous studies have implied that short‐term hypoxia (STH) might exert cardioprotective effects. However, the effects of STH on Ang II‐induced cardiomyocyte apoptosis remain unknown. In this study, we found that STH reduced myocardial apoptosis caused by Ang II via upregulation of the Mas receptor (MasR) to inhibit the AT1R signaling pathway. STH activates MasR to counteract the Ang II pro‐apoptotic signaling cascade by inhibiting IGF‐IIR expression via downregulation of JNK activation and reduction of SIRT1 degradation. Hence, HSF could remain deacetylated, and repress IGF‐IIR expression. These effects decrease the activation of downstream pro‐apoptotic and hypertrophic cascades and protect cardiomyocytes from Ang II‐induced injury. In addition, we also found that silencing MasR expression enhanced Ang II‐induced cardiac hypertrophy and the apoptosis signaling pathway. These findings suggest a critical role for MasR in cardiomyocyte survival. Altogether, our findings indicate that STH protects cardiomyocytes from Ang II‐stimulated apoptosis. The protective effects of STH are associated with the upregulation of MasR to inhibit AT1R signaling. STH could be a potential therapeutic strategy for cardiac diseases in hypertensive patients.
RUNX‐mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins
Authors: Anderson Gail , Mackay Nancy , Gilroy Kathryn , Hay Jodie , Borland Gillian , McDonald Alma , Bell Margaret , Hassanudin Siti Ayuni , Cameron Ewan , Neil James C. , Kilbey Anna 
Published: October 2017

AbstractRUNX gene over‐expression inhibits growth of primary cells but transforms cells with tumor suppressor defects, consistent with reported associations with tumor progression. In contrast, chromosomal translocations involving RUNX1 are detectable in utero, suggesting an initiating role in leukemias. How do cells expressing RUNX1 fusion oncoproteins evade RUNX‐mediated growth suppression? Previous studies showed that the TEL‐RUNX1 fusion from t(12;21) B‐ALLs is unable to induce senescence‐like growth arrest (SLGA) in primary fibroblasts while potent activity is displayed by the RUNX1‐ETO fusion found in t(8;21) AMLs. We now show that SLGA potential is suppressed in TEL‐RUNX1 but reactivated by deletion of the TEL HLH domain or mutation of a key residue (K99R). Attenuation of SLGA activity is also a feature of RUNX1‐ETO9a, a minor product of t(8;21) translocations with increased leukemogenicity. Finally, while RUNX1‐ETO induces SLGA it also drives a potent senescence‐associated secretory phenotype (SASP), and promotes the immortalization of rare cells that escape SLGA. Moreover, the RUNX1‐ETO SASP is not strictly linked to growth arrest as it is largely suppressed by RUNX1 and partially activated by RUNX1‐ETO9a. These findings underline the heterogeneous nature of premature senescence and the multiple mechanisms by which this failsafe process is subverted in cells expressing RUNX1 oncoproteins.