bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteolytic Processing of Neurexins by Presenilins Sustains Synaptic Vesicle Release
Authors: Servián-Morilla Emilia , Robles-Lanuza Estefanía , Sánchez-Hidalgo Ana C. , Camacho-Garcia Rafael J. , Paez-Gomez Juan A. , Mavillard Fabiola , Saura Carlos A. , Martinez-Mir Amalia , Scholl Francisco G. 
Published: December 2017

Proteolytic processing of synaptic adhesion components can accommodate the function of synapses to activity-dependent changes. The adhesion system formed by neurexins (Nrxns) and neuroligins (Nlgns) bidirectionally orchestrate the function of presynaptic and postsynaptic terminals. Previous studies have shown that presenilins (PS), components of the gamma-secretase complex frequently mutated in familial Alzheimer's disease, clear from glutamatergic terminals the accumulation of Nrxn C-terminal fragments (Nrxn-CTF) generated by ectodomain shedding. Here, we characterized the synaptic consequences of the proteolytic processing of Nrxns in cultured hippocampal neurons from mice and rats of both sexes. We show that activation of presynaptic Nrxns with postsynaptic Nlgn1 or inhibition of ectodomain shedding in axonal Nrxn1-β increases presynaptic release at individual terminals, likely reflecting an increase in the number of functional release sites. Importantly, inactivation of PS inhibits presynaptic release downstream of Nrxn activation, leaving synaptic vesicle recruitment unaltered. Glutamate-receptor signaling initiates the activity-dependent generation of Nrxn-CTF, which accumulate at presynaptic terminals lacking PS function. The sole expression of Nrxn-CTF decreases presynaptic release and calcium flux, recapitulating the deficits due to loss of PS function. Our data indicate that inhibition of Nrxn processing by PS is deleterious to glutamatergic function.SIGNIFICANCE STATEMENTTo gain insight into the role of presenilins (PS) in excitatory synaptic function, we address the relevance of the proteolytic processing of presynaptic neurexins (Nrxns) in glutamatergic differentiation. Using synaptic fluorescence probes in cultured hippocampal neurons, we report that trans-synaptic activation of Nrxns produces a robust increase in presynaptic calcium levels and neurotransmitter release at individual glutamatergic terminals by a mechanism that depends on normal PS activity. Abnormal accumulation of Nrxn C-terminal fragments resulting from impaired PS activity inhibits presynaptic calcium signal and neurotransmitter release, assigning synaptic defects to Nrxns as a specific PS substrate. These data may provide links into how loss of PS activity inhibits glutamatergic synaptic function in Alzheimer's disease patients.
Egészség-magatartással kapcsolatos attitűdök vizsgálata középiskolás és egyetemista fiatalok körében
Authors: Nagy Beáta Erika , Kovács Karolina Eszter 
Published: December 2017

Abstract: Introduction: Health awareness plays an important role in our life, which contains attitudes as well behavioural components. Social factors influencing health awareness were the basis of many previous investigations, measuring the effect of demographical and psychological factors. However, investigation of these factors usually happened with separated questions. Aim: The aim of the present study is to test a new questionnaire, which measures health behaviour and attitudes related to health awareness. Method: In present study, the attention was drawn to the introduction of a new questionnaire related to health behaviour, attitudes toward health awareness and factors influencing those and measured on population in Debrecen (SHTE 2017; n = 256). Results: the new measurement proved to be reliable based on Cronbach α analysis. This was created on the basis of focus content analysis of group conversations with 10 subscales and 35 items. Conclusions: It can be stated that gender, father’s educational level, objective and subjective financial status has a significantly negative effect; while sport, subjective health and fitness as well as subjective religiosity have a significantly positive effect which reflects previous findings and confirm the reliability of our questionnaire. Orv Hetil. 2017; 158(44): 1754–1760.
A laktátdehidrogenáz (LDH) prognosztikai jelentősége az onkológiában
Authors: Deme Dániel , Telekes András 
Published: December 2017

Abstract: Glycolysis is increased in most of the malignant cells, providing the largest proportion of energy needed for cell proliferation. Lactate dehydrogenase (LDH) catalyses the reversible process of pyruvate to lactate in anaerobic condition. LDHA isoenzyme expressed mainly by malignant cells, significantly increases lactate formation. Lactate induces the proliferation of oxygenated malignant cells, angiogenesis, and inhibits the innate and adaptive immune responses. Baseline serum LDH elevation correlates with shorter survival. The authors review the relevant studies exploring the correlation between LDH elevation and the prognosis of malignant diseases. Orv Hetil. 2017; 158(50): 1977–1988.
Acetazolamid orális alkalmazása mellett jelentkező chorioidealeválás két esete: ismert idioszinkráziás hatás szokatlan megjelenési formája?
Authors: Hári-Kovács András , Soós Judit , Gyetvai Tamás , Facskó Andrea , Végh Mihály 
Published: December 2017

Abstract: Sulpha drugs are widely employed in medicine for various diseases and disorders. During the last several decades, numerous papers had been published on supra ciliary and posterior choroidal effusion likely presenting as an idiosyncratic effect of these drugs especially of acetazolamide. In each publication, the effusion was associated with either an acute angle-closure glaucoma or transitory myopia or both of these as leading symptoms. In the current publication, authors report on two cases where the acetazolamide-induced choroidal effusion was an accidental finding without either a myopic shift in refraction or an acute elevation in intraocular pressure. To our best knowledge, ours is the first report in the literature describing this unusual, “silent” form of a sulpha drug-induced choroidal effusion. Since the choroidal involvement may vary in size and location, and is not necessarily associated with acute glaucoma and myopia, one can assume that a considerable amount of acetazolamide-related ocular side-effects will not be discovered. The above case report aims to draw the attention of other specialities to the need for ophthalmic examination for their patients taking sulpha drugs with acute visual deterioration. Orv Hetil. 2017; 158(50): 1998–2002.
Exploring the Information Source Preferences Among Canadian Adult Golf League Members
Authors: Davies Melissa , Gray Dianna 
Published: December 2017

With an aging demographic, and the abundance of physical inactivity in Canada, sport professionals need to understand how best to recruit and retain adults in sport and recreational activities, namely, golf leagues. Canadian golf league participants (N = 419; Mage = 62 years old) completed an online survey detailing their propensity to utilize a variety of information sources prior to making the decision to join a golf league. Results from a principal component analysis of a revised Information Sources Inventory, suggested that golfers in this sample were most likely to utilize Personal and Social sources of information associated with their league participation decision. While no differences emerged in information source preferences across Age or levels of Involvement, women (m = 4.12, SD = 1.30) were significantly more likely to utilize Public information sources than were men (m = 3.64, SD = 1.26). Implications from the information source preferences are discussed with the goal of generating more effective marketing strategies to recruit new golfers, lapsed golfers, or golfers who do not currently engage in league play.
BIBLICAL INTEGRATION IN A MATHEMATICS CLASSROOM: QUALITATIVE RESEARCH IN A SENIOR HIGH SCHOOL
Authors: Kristiana Tabita Gabriela , Winardi Yonathan , Hidayat Dylmoon 
Published: December 2017

<p>This article discusses to what extent mathematics teachers do Biblical integration in their class, explores the challenges that mathematics teachers face when they do or want to do Biblical integration, and explores the school’s expectation of Biblical integration for mathematics teachers with more clarity and intentionality. Research was conducted from September until October 2016. The research subjects were the curriculum coordinator, head of the Department of Mathematics, seven mathematics teachers, and 362 senior high students. The data collection techniques that were used were a semi-structured interview, and a questionnaire. The results of the research showed that the school’s expectation is that teachers should be able show how mathematics is capable of expressing truths about God’s work, God’s beauty, and God’s regularity because God created mathematics. All of the mathematics teachers modeled Biblical qualities. The challenges and obstacles that mathematics teachers were confronted with was that they had little time to find Biblical integration material, they did not have enough understanding, they had difficulty doing Biblical integration from the material, and the teachers were afraid that their explanations about Biblical integration would sound forced to students, especially non-Christian students.<em></em></p><p class="abstrak"><strong>ABSTRAK BAHASA INDONESIA: </strong>Artikel ini membahas sejauh mana guru matematika melakukan integrasi Alkitabiah di kelasnya, tantangan dan hambatan yang dihadapi oleh guru matematika saat mereka melakukan atau ingin melakukan integrasi Alkitabiah, dan untuk mencari tahu ekspetasi sekolah tentang integrasi Alkitabiah untuk guru matematika dengan lebih jelas dan mempunyai maksud. Penelitian ini dilakukan dari September sampai Oktober 2016. Subjek penelitian adalah kordinator kurikulum, kepala departemen matematika, tujuh guru matematika, dan 362 siswa sekolah menengah atas. Teknik pengumpulan data yang digunakan yaitu wawancara terencana-tidak terstruktur dan kuisioner. Hasil dari penelitian menunjukkan bahwa ekspetasi sekolah adalah bagaimana matematika mampu menjadi tempat untuk mengantarkan siswa mengenal kebenaran seperti pekerjaan Tuhan, keindahan Tuhan, keteraturan Tuhan karena Tuhan menciptakan matematika. Kemudian, semua guru matematika menjadi contoh kualitas Alkitabiah. Hambatan dan tantangan yang dihadapi guru matematika adalah kekurangan waktu untuk menemukan integrasi Alkitabiah dari materi, mereka juga tidak mempunyai pemahaman yang cukup, mereka merasa kesulitan dalam melakukan integrasi Alkitabiah, dan guru merasa takut jika penjelasannya tentang integrasi Alkitabiah terdengar memaksa bagi siswa, terkhusus siswa yang beragama lain.</p>
Weryfikacja systemu do planowania leczenia w brachyterapii metodą TLD
Authors: Matuszak Natalia 
Published: December 2017

Zjawisko termoluminescencji jest jedną z fundamentalnych metod luminescencji. Po napromienieniu, luminofor uwalnia energię zgromadzoną w postaci światła, o intensywności proporcjonalnej do pochłoniętej dawki. Emisja światła jest możliwa po uprzedniej ekspozycji promieniowaniem jonizującym bądź UV, a następnie wygrzaniu. Krzywe termoluminescencyjne obrazują efekt liniowego wzrostu temperatury, którym jest rejestracja ilości emitowanych kwantów luminescencji. Miarą pochłoniętej dawki jest amplituda piku równa scałkowanej powierzchni pod krzywą TL. Część fizyczną badań, obejmującą pomiary termoluminescencyjne przeprowadzono w Zakładzie Fizyki Jądrowej i Jej Zastosowań Uniwersytetu Śląskiego w Katowicach. Wszystkie czynności eksperymentalne dotyczące brachyterapii i tym samym wymagające użycia pożądanej aparatury zrealizowano w Zakładzie Radioterapii Katowickiego Centrum Onkologii. Weryfikacja opierała się na korelacji wyników dawek z planów leczenia, opartych na odmiennych algorytmach formalizujących obliczenia rozkładu dawki, z dawkami uzyskanymi na drodze pomiaru termoluminescencyjnego. Analiza wykazała, że metoda dozymetrii termoluminescencyjnej może być wykorzystana do weryfikacji dawek generowanych przez system planujący leczenie. Zgodność wyników jest możliwa przy uwzględnieniu wszystkich parametrów fizycznych pomiaru oraz warunków biologicznych.
Access to Infertility Consultations “What Women Tell Us About it”?
Authors: Remoaldo Paula , de Fátima da Silva Vieira Martins Maria , Faria Juliana Patrícia Alves , Veiga Paula 
Published: December 2017

Background:Infertility has been considered as a serious public health problem. Nevertheless, it is still very difficult to assess the epidemiology of this individual and public health problem. On the other hand, promotion of access to infertility treatments must be treated as a priority to national and regional policies.Objective:The aim was to evaluate the perception of women concerning the barriers and access to infertility consultations.Methods:Socio cultural and economic access to infertility consultations is detached and three municipalities of the northwest of Portugal were chosen as an example of a peripheral country. A quantitative/qualitative study was done with 60 women.Results:Three dimensions were evaluated: geographic and structural and functional access, economic access and sociocultural access. The main barriers were mainly identified in the last two dimensions. The economic access was less well evaluated by women bearing the cost of treatment (medication, and concentration of costs in a short period) which is difficult to bear.Conclusion:This can justify a greater involvement of the Portuguese Government, by developing policies for the reimbursement of part of the costs. Also, some changes in structural and functional access must be done with special regard to the separation of the infertility consultations from the reproductive medicine section. The setting of the teams, with a follow-up by the same team of health professionals is also needed.
Nanoneuromedicines for Neurodegenerative Diseases
Authors: Singh Ram , Geetanjali  
Published: December 2017

Introduction:
Neurodegenerative disease is a collective term for a number of diseases
that affect the neurons in the human brain. The location of the neuronal loss in the brain leads to the
specified disease based on the progression of the clinical symptoms. No drugs are available for
complete cure of these diseases. Most of the drugs only slow down the progression of neuronal
damage. The combination of drugs with nanotechnology gave a new promising hope for the treatment
of neurological disorders. Nanomedicines are extremely useful for safe, effective, target oriented
and sustained delivery. Due to their size in nanometer, they possess distinct and improved
properties in comparison to their bulk counterpart. The utility of nanomedicines in neurological
disorders including neurodegenerative diseases constitutes nanoneuromedicines.

Conclusion:
In this article, a comprehensive overview of the application of nanoneuromedicines in
neurodegenerative diseases such as Alzheimer’s Disease (AD), Parkinson’s Disease (PD) and
Amyotrophic Lateral Sclerosis (ALS) is provided.
PENINGKATAN MINAT KEWIRAUSAHAAN SISWA SMP DENGAN PENDEKATAN SCIENTIFIC SELL
Authors: Fitroni Zakki 
Published: December 2017

Abstrak: Pendidikan seni budaya merupakan mata pelajaran yang potensial dalam meningkatkan minat kewirausahaan siswa. Untuk memberi dampak yang signifikan terhadap minat siswa berwirausaha diperlukan pendekatan pembelajaran yang mampu memasukkan nilai kewirausahaan secara efektif ke dalam pembelajaran. Dengan memodifikasi pendekatan scientific dan menambahkan satu langkah lagi yaitu Sell (menjual) sehingga pendekatan ini dinamakan pendekatan Scientific Sell. Keterlaksanaan pendekatan scientific sell dalam materi melukis ragam hias pada media bangkiak, mampu meningkatkan minat siswa terhadap kewirausahaan siswa dengan menggunakan langkah; Mengamati, menanya mengumpulkan informasi, mengasosiasi, mencipta, menjual dan Mengkomunikasikan/refeksi. Keberhasilan pendekatan ini dapat dilihat dari hasil penilaian psikomotor dengan rata rata nilai yang diperoleh adalah 84,32% dan rata-rata nilai kognitif yang diperoleh adalah 82,19%. Sedangkan Nilai afektif didapat berdasarkan pengamatan minat siswa di siklus I sebesar 85,93%, dan mengalami peningkatan sebesar 2,55% sehingga menjadi 88,48% pada siklus II. Kata kunci: Kewirausahaan, Minat, Scientific Sell.
IMPLEMENTATION OF 2015 MENTORING PROGRAM IN ENGLISH DEPARTMENT OF UNIVERSITY MUHAMMADIYAH MALANG
Authors: Inayati Nina , Hikmah Nurbatra Laela , Khadijah Maro Rahmawati 
Published: December 2017

ABSTRACT The Mentoring Program of the English Department of UMM is an extra-curricular program designed to assist first year students to practice their English speaking and independent study. The speaking skills are focused on two specific skills; presentation and debate skills; while the English independent study introduces students to various English learning activities students could potentially integrate in their daily lives. The current study employs document analysis and survey as the methods of data collection. Then, content analysis is used to identify the salient themes and patterns occurring from the data to be presented based on the research problems. Analysis of the data shows that the program ran as planned and that some mentors developed the prepared lesson plans. As for the program evaluation, analysis of the survey results show that, in general, the program was viewed positively by the students. Some strengths mentioned were that the module was helpful and informative and that the mentors were fun and motivating. As for the weaknesses, Saturday morning schedule was considered bad option and that outdoor venues were less conducive some times. In light of the evaluation, some suggestions for the future program are offered, such as to improve the timing and venues. Keywords: Mentoring, English Learning, Speaking, Independent Study
Yksityisyys valvonnan verkoissa
Authors: Sirkkunen Esa 
Published: December 2017

Tässä artikkelissa tarkastelen yksityisyyden rakentumista verkkovalvonnan kontekstissa. Tarkastelen kehitystä neljästä näkökulmasta: selvennän verkkovalvonnan käsitettä, erittelen taloudellisen verkkovalvonnan toimintatapoja ja niiden vaikutusta yksityisyyteen, tutkin verkon alustojen käyttöehtoja yksityisyyden kannalta sekä esittelen verkon käyttäjien yksityisyyskäsityksiä. Edellisten perusteella esitän johtopäätöksissä ehdotuksia mediatutkimuksen tehtäviksi verkkovalvonnan ja sen seurausten tutkimuksessa.
Televisio- ja tuotantoyhtiöiden haasteet ja mahdollisuudet monimediaalisessa ympäristössä
Authors: Keinonen Heidi 
Published: December 2017

Television viihde- ja draamaohjelmat ovat muuttumassa monimediaalisiksi tuotannoiksi, jotka sisältävät itse ohjelmajaksojen lisäksi erilaisia ja eri alustoilla jaettavia sisältöjä. Tällaiset tuotannot tarjoavat televisioyhtiöille uudenlaisia mahdollisuuksia rakentaa katsojasuhdettaan, mutta ne myös haastavat monia televisiotuotannon käytäntöjä ja malleja. Tässä artikkelissa tarkastellaan, millaisia muutoksia monimediaalisuuden omaksuminen on tuonut suomalaiseen televisiotuotantoon. Artikkelissa analysoidaan suomalaisten ohjelmapäälliköiden ja televisiotuottajien kanssa tehtyjen haastattelujen pohjalta monimediaalisen televisiotuotannon käsitteitä ja käytäntöjä sekä televisiotuotantoa ja yleisradiotoimintaa liiketoimintana. Kaupallisille televisioyhtiöille monimediaalisten tuotantokäytäntöjen omaksuminen näyttää olevan luonteva askel sähköisen viestinnän kehityksessä, kun taas Ylen haasteena on löytää omat, julkisen palvelun arvoihin sopivat monimediaalisuuden muotonsa. Tuotantoyhtiöissä suurimmat haasteet puolestaan liittyvät uusien liiketoimintamallien kehittämiseen.
Kolmas tila suhteisuuden näyttämönä – mediaviitteet ja läheisten nimet yhteisöllisyyden osoittajina esiopetusikäisten lasten luovassa kirjoittamisessa
Authors: Mertala Pekka 
Published: December 2017

Pienten lasten luovaa kirjoittamista on tutkittu vähän ja yleensä vain teknistä tarkkuutta korostavan taitodiskurssin kautta. Kirjoittaminen voidaan kuitenkin ymmärtää myös tarkoitushakuisena sosiaalisena toimintana, jaettavaan muotoon taltioituina ideoina, näkemyksinä ja mielipiteinä – suhteina. Työssäni suhteisuuden teoreettisen viitekehyksen muodostaa kolmannen tilan käsite, jolla tarkoitan ei-institutionaalisen sekä institutionaalisen kasvuympäristön rajapinnoille muodostuvia molemmat kontekstit sisältäviä identiteettiperustaisia tiloja. Empiirinen aineisto koostuu esiopetusikäisten lasten päiväkotikontekstissa vapaan leikin aikana tuottamista (tietokone)kirjoituksista. Tarkastelen erityisesti sitä millaisia, keiden välisiä ja miten ilmaistuja suhteita lapset julkituovat kirjoituksissaan kolmannen tilan kautta. Kolmas tila esiintyi kirjoituksissa joko oman lähipiirin tai mediatekstien uudelleenkontekstualisointina. Valinnat eivät olleet sattumanvaraisia vaan kertoivat kiintymyksestä ja jo olemassa olevista tai toivotuista ystävyyssuhteista. Kirjoituksissa esiintyneiden lasten välittömään kokemusmaailmaan kuuluvien henkilöiden roolit ja relaatiot elivät kirjoituksissa omalakista elämäänsä, jossa esimerkiksi vanhempien ja lasten roolit usein sekoittuivat. Mediaviitteiden intersubjektiivinen suhteisuus ilmeni tarkoituksenmukaisena ja koordinoituna saman jaetun keskusteeman ympärillä pysyttelemisenä.
Internet julkisena toimintatilana<br>Osallistuvaa verkon käyttöä paikallisessa ympäristökiistassa
Authors: Bamberg Jarkko 
Published: December 2017

Artikkelissa tarkastellaan osallistuvaa informaatio- ja kommunikaatioteknologian käyttöä paikallisessa ympäristökiistassa. Aihetta lähestytään Tampereella Koskenniskan ajoneuvosillasta syntyneen julkisen keskustelun kautta. Tutkimusaineistona käytetään Koskenniskan siltaprosessin keskeisten toimijoiden haastatteluja, joilla kartoitettiin, miten ja miksi Internetiä käytettiin osallistumisen tukena. Artikkelin teoreettinen näkökulma kietoutuu osallistumisen, tilan ja julkisuuden käsitteiden ympärille, jotka auttavat ymmärtämään erilaisia kaupunkisuunnittelun osallistumisen muotoja julkisina toimintatiloina.
Artikkelissa esitellään ja eritellään Koskenniskan siltaprosessin aikana käytettyjä verkko-osallistumisen muotoja, joita olivat informaatiota prosessista tallentaneet nettisivut, keskustelufoorumit, viranhaltijoille ja luottamushenkilöille tehdyt kyselyt sekä havainnekuvat ja -piirrokset sillasta. Tutkimuksen tulokset osoittavat, että Internet on julkisena toimintatilana noussut haastamaan valtamediaa ja muita perinteisempiä julkisen toiminnan tiloja, mikä auttaa löytämään avaimia suljetun suomalaisen kunnallishallinnon avaamiseen.