bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of bleeding risk in patients with coronary artery disease on dual antiplatelet therapy
Authors: van der Meijden Paola E. J. , Henskens Yvonne M. C. , ten Cate-Hoek Arina J. , Cate Hugo ten , Vries Minka J. A. 
Published: December 2015

SummaryPatients with coronary artery disease are usually treated with dual antiplatelet therapy (DAPT) after percutaneous coronary intervention. Patients on DAPT are at risk of both ischaemic and bleeding events. Although side-lined for a long time, real-life studies have shown that both the incidence and the associated morbidity and mortality of outof-hospital bleeding are high. This indicates that prevention of (postinterventional) bleeding is as important as prevention of ischaemia. For this purpose it is crucial to reliably identify patients with a high bleeding risk. In order to postulate an algorithm, which could help identifying these patients, we performed a systematic review to determine the value of previously proposed prognostic modalities for bleeding. We searched and appraised the following tools: platelet function tests, genetic tests, bleeding scores and questionnaires and haemostatic tests. Most studies indicated that low on-treatment platelet reactivity (LTPR), as measured by several platelet function tests, and the carriage of CYP2C19*17 allele were independent risk factors for bleeding. A bleeding score also proved to be helpful in identifying patients at risk. No studies on haemostatic tests were retrieved. Several patient characteristics were also identified as independent predictors of bleeding, such as older age, female sex and renal failure. Combining these risk factors we propose an algorithm that would hypothetically facilitate identification of those patients at highest risk, warranting prevention measures for bleeding. This could be a starting point for further research concerning the topic.
Early Visual Cortex Dynamics during Top–Down Modulated Shifts of Feature-Selective Attention
Authors: Müller Matthias M. , Trautmann Mireille , Keitel Christian 
Published: December 2015

Abstract
Shifting attention from one color to another color or from color to another feature dimension such as shape or orientation is imperative when searching for a certain object in a cluttered scene. Most attention models that emphasize feature-based selection implicitly assume that all shifts in feature-selective attention underlie identical temporal dynamics. Here, we recorded time courses of behavioral data and steady-state visual evoked potentials (SSVEPs), an objective electrophysiological measure of neural dynamics in early visual cortex to investigate temporal dynamics when participants shifted attention from color or orientation toward color or orientation, respectively. SSVEPs were elicited by four random dot kinematograms that flickered at different frequencies. Each random dot kinematogram was composed of dashes that uniquely combined two features from the dimensions color (red or blue) and orientation (slash or backslash). Participants were cued to attend to one feature (such as color or orientation) and respond to coherent motion targets of the to-be-attended feature. We found that shifts toward color occurred earlier after the shifting cue compared with shifts toward orientation, regardless of the original feature (i.e., color or orientation). This was paralleled in SSVEP amplitude modulations as well as in the time course of behavioral data. Overall, our results suggest different neural dynamics during shifts of attention from color and orientation and the respective shifting destinations, namely, either toward color or toward orientation.
Impact of Assimilating Surface Velocity Observations on the Model Sea Surface Height Using the NCOM-4DVAR*
Authors: Carrier Matthew J. , Ngodock Hans E. , Muscarella Philip , Smith Scott 
Published: December 2015

Abstract
The assimilation of surface velocity observations and their impact on the model sea surface height (SSH) is examined using an operational regional ocean model and its four-dimensional variational data assimilation (4DVAR) analysis component. In this work, drifter-derived surface velocity observations are assimilated into the Navy’s Coastal Ocean Model (NCOM) 4DVAR in weak-constraint mode for a Gulf of Mexico (GoM) experiment during August–September 2012. During this period the model is trained by assimilating surface velocity observations (in a series of 96-h assimilation windows), which is followed by a 30-day forecast through the month of October 2012. A free-run model and a model that assimilates along-track SSH observations are also run as baseline experiments to which the other experiments are compared. It is shown here that the assimilation of surface velocity measurements has a substantial impact on improving the model representation of the forecast SSH on par with the experiment that assimilates along-track SSH observations directly. Finally, an assimilation experiment is done where both along-track SSH and velocity observations are utilized in an attempt to determine if the observation types are redundant or complementary. It is found that the combination of observations provides the best SSH forecast, in terms of the fit to observations, when compared to the previous experiments.
Multidetector computed tomographic assessment of the normal diameters for the thoracic aorta and pulmonary arteries in infants and children
Authors: Bayindir Petek , Bayraktaroglu Selen , Ceylan Naim , Savas Recep , Alper H Hudaver 
Published: December 2015

Background Knowledge of the normal size of the thoracic aorta and pulmonary arteries is important regarding the detection of the abnormal and valuable in the treatment of patients with congenital and acquired cardiovascular diseases. Purpose To determine the normal diameters of the thoracic vascular structures of pediatric participants on contrast-enhanced multidetector computer tomography (MDCT) scans. Material and Methods Between July 2010 and July 2014, the MDCT examinations obtained from 520 participants (age range, 0–18 years; mean age, 8.49 years ± 5.54 [standard deviation]; male:female ratio, 1.6:1) with normal cardiovascular examinations were retrospectively evaluated. Patients were divided into six groups according to their age. Diameters of the ascending aorta (AA), descending aorta (DA), main pulmonary artery (MPA), right pulmonary artery (RPA), and left pulmonary artery (LPA) were measured. Results The diameters of the thoracic vascular structures increased with age and the statistical difference among the age groups and genders were significant. The vascular structures in male patients tended to have higher dimensions than female patients. The LPA demonstrated higher mean values than the RPA in each age group. The mean ratio PA (MPA/AA) is 0.93 ± 0.08 for pediatric participants and it is slightly higher in girls compared to boys (0.93 ± 0.07 and 0.92 ± 0.07, respectively). The level of pulmonary artery bifurcation moves caudally with increasing age with thoracal 6 vertebra being the most common for all age groups (53.3%). Conclusion We believe that the results of our study can serve as a potential reference in differentiating the normal from the abnormal size of the aorta and pulmonary arteries on chest MDCT studies in the pediatric population.
Comparative effectiveness of onabotulinumtoxinA versus oral migraine prophylactic medications on headache-related resource utilization in the management of chronic migraine: Retrospective analysis of a US-based insurance claims database
Authors: Hepp Zsolt , Rosen Noah L , Gillard Patrick G , Varon Sepideh F , Mathew Nitya , Dodick David W 
Published: December 2015

Background Migraine, especially chronic migraine (CM), causes substantial disability; however, health care utilization has not been well characterized among patients receiving different migraine prophylactic treatments. Methods Using a large, US-based, health care claims database, headache-related health care utilization was evaluated among adults with CM treated with onabotulinumtoxinA or oral migraine prophylactic medications (OMPMs). Headache-related health care utilization was assessed at six, nine, and 12 months pre- and post-treatment. The primary endpoint was the difference between pre- and post-index headache-related health care utilization. A logistic regression model was created to test the difference between onabotulinumtoxinA and OMPM-treated groups for headache-related emergency department (ED) visits and hospitalizations. Results Baseline characteristics were comparable between groups. The proportion of patients with ED visits or hospitalizations for a headache-related event decreased after starting onabotulinumtoxinA, but increased after starting an OMPM, for all three cohorts. Regression analyses showed that the odds of having a headache-related ED visit were 21%, 20%, and 19% lower and hospitalization were 47%, 48%, and 56% lower for the onabotulinumtoxinA group compared to the OMPM group for the six-month, nine-month, and 12-month post-index periods, respectively. Conclusions When compared with similar patients who initiated treatment with OMPM, onabotulinumtoxinA was associated with a significantly lower likelihood of headache-related ED visits and hospitalizations.
A modeling study of augmenting coarse-grid 3D controlled-source electromagnetics with data from a towed receiver array
Authors: Morten Jan Petter , Poudroux Jean-Michael , Mittet Rune 
Published: December 2015

We have considered the simultaneous 3D inversion of controlled-source electromagnetic data from a towed receiver array and a coarse grid of stationary seabed receivers. Our 3D synthetic model demonstrated the sensitivity and effect on imaging of towed and seabed receiver data. The short-offset data from the towed receivers at 1–3 km offset are effective at resolving a shallow resistor at a 400-m burial depth. On the other hand, the data from the stationary seabed receivers have less noise and will resolve the 3D geometry of resistive structures buried at the 1–2 km depths typical of a hydrocarbon reservoir. We have determined how the complementary sensitivity of data from the two receiver types can be used in simultaneous inversion to recover the shallow and deep resistors.
α-Cell Dysfunctions and Molecular Alterations in Male Insulinopenic Diabetic Mice Are Not Completely Corrected by Insulin
Authors: Dusaulcy Rodolphe , Handgraaf Sandra , Heddad-Masson Mounia , Visentin Florian , Vesin Christian , Reimann Franck , Gribble Fiona , Philippe Jacques , Gosmain Yvan 
Published: December 2015

Abstract
Glucagon and α-cell dysfunction are critical in the development of hyperglycemia during diabetes both in humans and rodents. We hypothesized that α-cell dysfunction leading to dysregulated glucagon secretion in diabetes is due to both a lack of insulin and intrinsic defects. To characterize α-cell dysfunction in diabetes, we used glucagon-Venus transgenic male mice and induced insulinopenic hyperglycemia by streptozotocin administration leading to alterations of glucagon secretion. We investigated the in vivo impact of insulinopenic hyperglycemia on glucagon-producing cells using FACS-sorted α-cells from control and diabetic mice. We demonstrate that increased glucagonemia in diabetic mice is mainly due to increases of glucagon release and biosynthesis per cell compared with controls without changes in α-cell mass. We identified genes coding for proteins involved in glucagon biosynthesis and secretion, α-cell differentiation, and potential stress markers such as the glucagon, Arx, MafB, cMaf, Brain4, Foxa1, Foxa3, HNF4α, TCF7L2, Glut1, Sglt2, Cav2.1, Cav2.2, Nav1.7, Kir6.2/Sur1, Pten, IR, NeuroD1, GPR40, and Sumo1 genes, which were abnormally regulated in diabetic mice. Importantly, insulin treatment partially corrected α-cell function and expression of genes coding for proglucagon, or involved in glucagon secretion, glucose transport and insulin signaling but not those coding for cMAF, FOXA1, and α-cell differentiation markers as well as GPR40, NEUROD1, CAV2.1, and SUMO1. Our results indicate that insulinopenic diabetes induce marked α-cell dysfunction and molecular alteration, which are only partially corrected by in vivo insulin treatment.
Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy
Authors: Neumann Ursula H. , Denroche Heather C. , Mojibian Majid , Covey Scott D. , Kieffer Timothy J. 
Published: December 2015

Abstract
Leptin can reverse hyperglycemia in rodent models of type 1 diabetes. However, these models have used chemical or immune mediated β-cell destruction where insulin depletion is incomplete. Thus it is unknown which actions of leptin are entirely insulin independent, versus those which require insulin. To directly assess this we maximized blockage of insulin action using an insulin receptor antagonist in combination with streptozotocin-diabetic mice; leptin treatment was still able to reduce blood glucose. Next, we leptin-treated adult insulin knockout (InsKO) mice. Remarkably, leptin-treated InsKO mice were viable for up to 3 weeks without insulin therapy. Leptin treatment reduced plasma corticosterone, glucagon, β-hydroxybutyrate, triglycerides, cholesterol, fatty acids and glycerol. However, leptin-treated InsKO mice exhibited overt fed hyperglycemia and severe fasting hypoglycemia. Therefore, leptin can normalize many metabolic parameters in the complete absence of insulin, but blood glucose levels are volatile and the length of survival finite.
Palestine in the British press: A Postcolonial Critical Discourse Analysis
Authors: Sanz Sabido Ruth 
Published: December 2015

Abstract
This article examines the representations of the Israeli Palestinian conflict in the British press, starting from the premise that media representations in Britain should be analysed in relation to Britain’s role as a postcolonial power. Focusing on Britain’s colonial and postcolonial connection to this conflict, this study is based on the findings of a Postcolonial Critical Discourse Analysis of four British national newspapers (the Guardian, or Manchester Guardian; The Times; the Daily Herald, or the Sun; and the Daily Mirror) at four different points during the history of the conflict. The findings indicate that the classification of Palestine, Palestinians, Israel, Israelis, Jews, Zionists and Arabs as agents of political violence evolved over time, as violent acts and agents were perceived differently according to the dominant political discourse during each period. The contextualization of the conflict also provides insights into how the British press constructed its various ideological positions in relation to the clashes, and the extent to which the British Mandate remained visible in the later coverage of the armed confrontations. The postcolonial approach adopted in this study indicates that the generalized lack of references to the historical facts that underpin Britain’s role in the development of the conflict represents an attempt to move away from the historical responsibilities derived from colonial encounters. This framework therefore helps to restore the largely neglected historical connection of the British Mandate to its proper place in the analysis of these mediated events.
Representing Islam in the age of neo-orientalism: Media, politics and identity
Authors: Al-Zo’by Mazhar 
Published: December 2015

Abstract
The aim of this article is to examine the persistent charterer of orientalist discourse in western mass media narratives by analysing the function of the ‘native subject’ and ‘native attitude’ in the constitution of neo-orientalism. While the classical orientalist representational vision has dominated the western media and popular narratives of Islam and Arabs throughout the twentieth century, it is the contention of this article that new forms and formations of orientalist discourse have emerged corresponding with the West’s new imperial designs in the post-Cold War era and especially during the so-called ‘War on Terror’. The rise of these neo-orientalist strategies in the western media finds its elaborate articulation in the deployment of ‘native subjects’ as specialists who provide a crucial function in facilitating oriental discourse for the service of hegemonic (military and cultural) ideology. Relying on interpretive discourse analysis, this article will illustrate how a serious engagement with current orientalist media ideology warrants a critical examination of the ways its new strategies have mutated to include the native as a source for its ideological narratives. Whereas in classical orientalist narratives the ‘oriental native’ had indispensably occupied central status as the ‘object’ of ‘authentic’ oriental knowledge, in the neo-orientalist discourse the ‘native’ becomes the ‘voice/authority’ of the reorientalized native cultures.
Reinventando alojamientos turísticos. Casos de éxito y soluciones innovadoras
Authors: Temes Cordovez Rafael Ramón 
Published: December 2015

Reseña BibliográficaReinventando alojamientos turísticos. Casos de éxito y soluciones innovadorasMoisés R.Simancas Cruz y Raúl Hernández Martín (Eds.)Cátedra de Turismo de Cajacanarias - ASAHOTEL - Universidad de La Laguna, Tenerife1ª Edición abril 2015, ISBN: 978-84-606-5816-0, 271 páginas
Non-familial Cherubism – Report of a case
Authors: Patussi Cleverson , Sassi Laurindo Moacir , Bixofix Regiane Benez , Silva William Phillip Pereira da , Shussel Juliana Lucena 
Published: December 2015

Introduction: The Cherubism is a rare disease that affects the middle and lower third of the face in individuals at the time of childhood. It is a rare hereditary benign bone disease with an autosomal dominant inheritance. The familial distribution may affect different generations and isolated non-familial cases have also been reported in literature. Lesions appear as cystic multilocular radiolucencies, histologically, resembles central giant cell granluloma and hyperparathyroidism brown tumor with numerous randomly distributed multinucleated giant cells and vascular spaces within a fibrous connective tissue stroma. Objectives: The aim of this study is to report the importance of the diagnosis of this pathology and the variety of treatments available in the literature, thus guiding to an individualized treatment. Case Report: Caucasian 8 years-old female, in good general condition, was referred to Service of Oral and Maxillofacial Surgery of Erasto Gaertner Hospital (EGH), Curitiba – PR, Brazil, complaining of bilateral swelling of the maxilla and mandible since 4 years-old. Apparently, the girl is the first one who developed the genetic pathology in at least 4 generation of her family. After biopsy, cherubism diagnosis was confirmed and the treatment of choice was periodic monitoring. Discussion: Cherubism studies with long-term follow-up with clinical and radiographic documentation indicate that the spontaneous resolution of bone lesions is rare. Treatment of cherubism is controversial and various modalities have been reported as the use of calcitonin, osseous plasty surgery, curettage, orthognathic surgery, liposuction and palliative treatments.
Nine-year clinical evaluation of composite resins in Class III restorations
Authors: Sá Fátima Cristina , Fagundes Ticiane Cestari , Baseggio Wagner , Bresciani Eduardo , Barata Terezinha Jesus Esteves , Franco Eduardo Batista 
Published: December 2015

Objective: The aim of this study was to evaluate the nine-year clinical performance of Class III composite restorations using two microhybrid anterior composite resins [Magic™-Vigodent/(F) and Z100™-3M ESPE/(Z)]. Material and Methods: The study was a randomized controlled trial, following the split mouth design. Seventy restorations were placed, thirty-five for each resin composite into 35 patients. The restorations were placed by one operator according to the manufacturers’ specifications. Two independent evaluators conducted the clinical evaluation using modified USPHS criteria. After nine-years, 56 restorations (28F-28Z) were evaluated. Data were analyzed using Chi-square, Exact Fisher and McNemar tests (p<0.05). Results: No postoperative sensitivity, secondary caries and loss of anatomic form was observed after nine-years for both composites. There were no significant differences between the two composites tested at baseline and after nine-years. Significant differences for Z and F restorations between baseline and nine-year with respect to color matching and for F regarding the marginal integrity were detected. Conclusion: The clinical performance of both materials was considered acceptable after the 9-year evaluation.
Long-term dental follow-up in hematological stem cells transplantation children
Authors: Valente Júnior Luiz Alberto , Santos Paulo Sérgio da Silva , Coracin Fabio Luiz , Frascino Alexandre Viana , Fava Marcelo , Odone Filho Vicente 
Published: December 2015

Objective: The aim of this paper is to update the current published content about the craniofacial long-term development disturbances of childhood hematopoietic stem-cell transplantation (HSCT) and the preparative regimens for the onco-hematological malignancies treatments. Material and Methods: Two authors independently reviewed the published articles about long-term effects of childhood HSCT that fitted in to predetermined inclusion/exclusion criteria: clear definition of exposure or intervention, standard outcomes measurement and appropriate statistical analysis. Results: Twelve papers matched all the previous established eligibility criteria and were included in this review. The children’s age at HSCT were related to a higher risk of dental development disturbances, such as agenesis, dental hypoplasia, root stunting, crown-root proportion alterations, and microdontia. Craniofacial vertical growth was impaired in the irradiated patients without antero-posterior or latero-lateral impairment. Temporomandibular joint dysfunction was found to be more prevalent in the patients who was diagnosed with graft-versus-host disease. Conclusion: The late effects of craniofacial development disturbances leads to several aesthetic and functional impairment, periodontal bone resorption with consequent impairment of chewing ability, and risk of early tooth loss often associated with life’s quality impairment. Further investigations should be performed to provide accurate information for patients, parents and health care professionals. Keywords: Dental development. Craniofacial growth. Bone marrow transplantation. Hematopoietic stem-cell transplantation. Chemotherapy. Radiotherapy.
Predicting the Sprint Performance of Adolescent Track Cyclists Using the 3-Minute All-out Test
Authors: Waldron Mark , Gray Adrian , Furlan Nicola , Murphy Aron 
Published: December 2015

AbstractWaldron, M, Gray, A, Furlan, N, and Murphy, A. Predicting the sprint performance of adolescent track cyclists using the 3-minute all-out test.J Strength Cond Res30(8): 2299–2306, 2016—This study aimed to predict 500-m time trial (TT) and 2,000-m pursuit speed of adolescent cyclists (age range = 13–15 years) using mechanical parameters derived from a critical power (CP) test and anthropometric variables. Ten well-trained competitive cyclists were assessed for body composition, body mass, stature, and frontal surface area (FSA), as well as completing the CP test. The personal best speed (km·h−1) of each rider during competition in 500-m TT and 2,000-m pursuit races was predicted based on the CP test data and anthropometric profiles using multiple regression analysis. A combination of the CP·FSA−1and internal (predicted) to external work ratio performed by the cyclists (Wint:Wext) predicted 500-m TT speed (R2= 0.97; standard error of the estimate (SEE) = 0.82,P≤ 0.001), whereas a combination of mean power·FSA−1(mean power) and body fat percentage predicted 2,000-m pursuit speed (R2= 0.90; SEE = 1.5,p< 0.001). Between 90 and 97% of the variance in the sprint performance of adolescent cyclists can be explained by mechanical and anthropometric parameters, derived from a single visit to the laboratory. The tests and equations provided can be adopted by coaches to predict performance and set appropriate training intensities.