bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dr. med. Skander Bouassida - „Ohne Schmiergeld oder Gefälligkeiten beim Personal geht nichts“
Authors: Sickinger Nina 
Published: December 2017

Ausländische Mitarbeiter berichten aus deutschen Kliniken
Dr. med. Skander Bouassida (42) ist halb tunesischer, halb deutscher Abstammung. Er arbeitete zunächst als Chirurg in Tunesien, sehnte sich dann jedoch aufgrund der Korruption und der Arbeitsbedingungen dort bald wieder nach Deutschland zurück. Inzwischen ist er hier Chefarzt einer chirurgischen Klinik.
Clinical Trial Design for Alcoholic Hepatitis
Authors: Szabo Gyongyi 
Published: December 2017

AbstractAlcoholic hepatitis (AH) is an acute and clinically distinct manifestation of alcoholic liver disease. While severe AH causes 30% or higher mortality in 3 months, treatment options are limited and ineffective. Recent advances on the understanding of the pathomechanisms of AH have identified numerous potential targets for new therapeutic interventions. Many of those targets are currently under preclinical testing and/or in human clinical trials for nonalcoholic steatohepatitis. Thus, the field of AH should be ready to launch new efforts and targeted clinical trials for this underserved patient population. There are remaining challenges in designing clinical trials in AH that include definition of the severity of disease, common data elements in clinical trial design, and selection of clinically meaningful endpoints. Future efforts and consensus meetings between regulatory agencies, academic and clinical experts, and industry will be instrumental to advance this emerging and greatly needed field of clinical investigations.
Systematic Review and Meta-Analysis: Prevalence of Small Intestinal Bacterial Overgrowth in Chronic Liver Disease
Authors: Shah Ayesha , Shanahan Erin , Macdonald Graeme , Fletcher Linda , Ghasemi Pegah , Morrison Mark , Jones Mike , Holtmann Gerald 
Published: December 2017

AbstractThe authors conducted a meta-analysis of the prevalence of small intestinal bacterial overgrowth (SIBO) in patients with chronic liver disease (CLD) and controls. Using the search terms “small intestinal bacterial overgrowth (SIBO)” and “chronic liver disease (CLD)” or “cirrhosis,” 19 case-control studies were identified. Utilizing breath tests, the prevalence of SIBO in CLD was 35.80% (95% CI, 32.60–39.10) compared with 8.0% (95% CI, 5.70–11.00) in controls. Using culture techniques, the prevalence was 68.31% (95% CI, 59.62–76.00) in CLD patients as compared with 7.94% (95% CI, 3.44–12.73) in controls. No difference between cirrhotic and noncirrhotic patients was found. SIBO is significantly more frequent in CLD patients as compared with controls. The association of SIBO and CLD was not confined to patients with advanced CLD, suggesting that SIBO is not a consequence of advanced liver disease but may play a role in the progression of CLD.
Long-Term Functional Results of a Wrist Exercise Program for Patients with Palmar Midcarpal Instability
Authors: Sulkers G. S. I. , Videler A. J. , Strackee S. D. , Smeulders M. J. C. , Mulders M. A. M. 
Published: December 2017

Background Patients with palmar midcarpal instability have symptoms of pain, combined with clinical signs of abnormal mobility on stressing the joint, an unpredictable blockade feeling, and a noticeable clunk, in the absence of an underlying trauma. No data are available on the effect of conservative treatment for these patients.
Purpose The purpose of this study was to evaluate the effect and the long-term functional outcomes of a wrist exercise program in patients with palmar midcarpal instability.
Patients and Methods All patients diagnosed with palmar midcarpal instability between 2005 and 2011 were included. Patients completed the Patient-Rated Wrist and Hand Evaluation (PRWHE) and the Short Form-36 health (SF-36) questionnaires, scaled their perceived pain before and after treatment, and indicated the effect of the received treatment.
Results A total of 119 patients diagnosed with palmar midcarpal instability were included. The median follow-up time was 6 years (IQR 4.5–7.0). The median PRWHE score after hand therapy was 35.5 and the median mental component of the SF-36 score was 53.9 and the physical component was 45.2. The median perceived pain reduced from eight to four and the median therapeutic effect of the wrist exercise program was five.
Conclusion Although palmar midcarpal instability remains to be a chronic disease, the effectiveness of our wrist exercise program is promising with acceptable long-term functional results and a good quality of life.
Level of Evidence Level IV, retrospective cohort study.
Topical Mitomycin C Application in Pediatric Patients with Recurrent Esophageal Strictures—Report on Unfavorable Results
Authors: Zimmer Julia , Gosemann Jan-Hendrik , Ure Benno , Lacher Martin , Boehm Roland , Madadi-Sanjani Omid 
Published: December 2017

Objective Recurrent esophageal strictures (ESs) following esophageal atresia repair or caustic ingestion represent a common clinical problem. Recently, Mitomycin C was reported to improve the outcome of patients by reducing the number of endoscopic dilatations. However, other groups failed to exhibit a beneficial effect. We report on our experience with topic Mitomycin C application following endoscopic dilatation for recurrent ES.
Methods Retrospective chart review of patients with ES treated at the Hannover Medical School (Location A) and the University of Leipzig (Location B) between 2009 and 2015. A Mitomycin C-soaked cotton swab was endoscopically placed at the area of stricture in all subjects. Successful treatment was defined as resolution of stricture after Mitomycin C therapy with not more than three dilatations thereafter. Our results were compared with published outcomes of alternative studies that involved 10 or more patients.
Results A total of 11 children received Mitomycin C concurrently with endoscopic dilatations. Seven children (64%) had gross type C esophageal atresia, two patients (18%) gross type A esophageal atresia, and two children (18%) caustic injury.After a median follow-up of 34 months (range, 14–75 months) and a median number of 3 ± 2.5 dilatations with Mitomycin C application per patient (range, 1–9), 6 of 11 patients (55%) achieved a resolution of their strictures. Five patients (45%) did not respond to Mitomycin C therapy, of which two needed esophageal redo-surgery.
Conclusion We failed to confirm the high success rates of Mitomycin C treatment for recurrent ESs. Given the fact that there is limited data to prove the beneficial effect of Mitomycin C treatment, pediatric surgeons should carefully consider whether the advantages of this therapy outweigh the necessity of life-long endoscopic follow-ups. Further randomized controlled studies are recommended.
Day of Week and Surgery Location Effects on Stay Length and Cost for Total Joint Arthroplasty: Academic versus Orthopaedic-Specific Hospital
Authors: Peterson Blake , Thompson Samuel , Cook James , Aggarwal Ajay , Martino John 
Published: December 2017

AbstractDemand for total hip (THA) and knee arthroplasties (TKA) is expected to rise sharply by 2030. Increasing demand in conjunction with financial pressure requires the use of cost-effective total joint arthroplasty (TJA) strategies. This study examined the effects that day of week and surgery location [academic (AH) versus orthopaedic-specific (OsH) hospital] have on length of stay (LOS) and cost for primary TJA patients in one multihospital university-based medical center. An Institutional Review Board-approved database of adult patients undergoing primary THA or TKA from June 2013 to December 2014 was constructed. Surgery location, day of procedure, age, American Society of Anesthesiologists (ASA) classification, LOS, and cost were recorded for each patient. Data were compared for significant differences using analysis of variance, t-Test or rank sum and for strength of correlations using Pearson's or Spearman's tests. A total of 1,291 patients met inclusion criteria. OsH showed significantly lower cost and shorter LOS than AH. Wednesday surgeries had significantly higher cost and longer LOS than all other days. Friday surgeries had significantly lower cost and shorter LOS than other days. ASA 3 and 4 were associated with the highest cost and longest LOS. LOS had a moderately strong direct correlation to cost. ASA did not have a strong correlation with LOS or cost. Data separated for THA and TKA showed similar results. At our institution, OsH provides more consistent and lower LOS and cost across all ASA classes. Wednesday and Thursday surgeries have increased LOS and cost than other days, which may be due to weekend discharge difficulties (average LOS is 3.0 days).
Physiotherapeutische Werkzeuge zur funktionellen Mobilisation von Narben und Bindegewebe sowie Dosierung bei
großflächigen Narbenplatten
Authors: Koller T , Ruegg C , Gut V 
Published: December 2017

ZusammenfassungDie jährlichen Statistiken zeigen eine zunehmende Anzahl an Operationen. Aus diesem Grund werden Physiotherapeuten in ihrer täglichen Praxis
mit einer Fülle von Narben konfrontiert. Bei einem großen Teil dieser Narben verläuft die Wundheilung asymptomatisch, ohne die
Funktionalität einzuschränken. Aber wie sieht die richtige und funktionsverbessernde Behandlung von symptomatischen und mit einer massiven
Funktionseinschränkung einhergehenden Narben aus?Diese Arbeit gibt einen Überblick über gewebephysiologische Aspekte der Wund- und Narbenheilung und beleuchtet mögliche Behandlungsansätze
bei Komplikationsnarben.
Clinical outcomes of endoscopic submucosal dissection for superficial esophageal neoplasms extending to the cervical esophagus
Authors: Ariyoshi Ryusuke , Toyonaga Takashi , Tanaka Shinwa , Abe Hirofumi , Ohara Yoshiko , Kawara Fumiaki , Ishida Tsukasa , Morita Yoshinori , Umegaki Eiji , Azuma Takeshi 
Published: December 2017

Abstract
Background The feasibility and safety of endoscopic submucosal dissection (ESD) for superficial esophageal neoplasms extending to the cervical esophagus currently remain unknown because of the limited number of cases. We aimed to clarify the clinical outcomes of these cases.
Methods This was a case series study conducted at a single institution that enrolled 26 consecutive patients with superficial esophageal neoplasms extending to the cervical esophagus who underwent ESD between July 2003 and December 2015.
Results En bloc and complete resection rates were both 100 % and no major intraprocedural complications occurred. Thirteen patients were treated with prophylactic steroid therapy. The incidence of postoperative stricture in patients with a circumferential mucosal defect of more than three-quarters was 72.7 %. Four patients required entire circumferential resection, with perforation occurring after endoscopic balloon dilation (EBD) in two and EBD being required for more than 1 year in the other two.
Conclusions ESD including the cervical esophagus is technically feasible. Circumferential resection may cause refractory postoperative stricture or post-EBD perforation, so needs to be avoided where possible.
Severe Rhabdomyolysis Associated With RSV
Authors: Bender James , Chew Rusheng , Lin Belinda Bin , Athan Eugene 
Published: December 2017

AbstractSevere rhabdomyolysis is associated with morbidity and mortality. We report on a previously well male who developed severe rhabdomyolysis, sepsis, and multi-organ failure. The patient made a complete recovery. Extensive microbiological testing was only positive for RSV, making this the first reported case of adult RSV-related rhabdomyolysis in the literature.
CHOROIDAL THICKENING AND PACHYCHOROID IN CUSHING SYNDROME
Authors: Wang Erqian , Chen Shi , Yang Hongbo , Yang Jingyuan , Li Yanlong , Chen Youxin 
Published: December 2017

Purpose:
To investigate subfoveal choroidal thickness and pachychoroid and their correlation with hormone level in patients with endogenous Cushing syndrome (CS).

Methods:
We enrolled a consecutive series of patients with CS and healthy controls. All participants had swept-source optical coherence tomography. All patients with CS had hormone test including morning plasma-free cortisol, 24-hour urine-free cortisol (24UFC), and plasma adrenocorticotropic hormone. We compared subfoveal choroidal thickness and pachychoroid changes between two groups. We performed univariate and multivariate analysis to study correlation between hormone level and choroid thickness as well as pachychoroid in patients with CS.

Results:
Compared with control group, Cushing group had significantly greater subfoveal choroidal thickness (371.6 ± 114.9 and 320.0 ± 74.0, P = 0.002) and higher proportion of eyes with pachychoroid (53.1 and 14.3%, P < 0.001). Subfoveal choroidal thickness was significantly correlated with 24UFC (P = 0.007) but not with plasma-free cortisol (P = 0.48) or adrenocorticotropic hormone (P = 0.56). Pachychoroid was significantly correlated with 24UFC (P = 0.03) but not with plasma-free cortisol (P = 0.24) or adrenocorticotropic hormone (P = 0.32).

Conclusion:
There was a positive correlation between elevated 24UFC and choroid thickening as well as pachychoroid, indicating the importance of normal endogenous cortisol level in maintaining the human choroid vasculature.
Prospective Evaluation of Standalone XEN Gel Implant and Combined Phacoemulsification-XEN Gel Implant Surgery: 1-Year Results
Authors: Mansouri Kaweh , Guidotti Jacopo , Rao Harsha L. , Ouabas Adel , D’Alessandro Elisa , Roy Sylvain , Mermoud André 
Published: December 2017

Purpose:
To evaluate the safety and efficacy of XEN gel implant (Allergan Inc., Irvine) as a standalone versus combined XEN-Phacoemulsification surgery (XEN+cataract) in glaucoma patients.

Methods:
Prospective, interventional study. One-hundred forty-nine eyes (113 patients) with open-angle glaucoma and uncontrolled intraocular pressure (IOP) despite medical treatment were enrolled at a tertiary glaucoma center and followed up for a minimum of 1 year. Approximately two-thirds of patients underwent combined XEN+cataract surgery, while the remainder had XEN alone surgery. Primary outcome was a 20% or more decrease in IOP from medicated baseline at 1 year. Mean IOP, mean number of medications at last follow-up, and incidence of adverse effects were analyzed.

Results:
Of 149 enrolled eyes, data of 87 (58%) were available at 1 year. A total of 109 (73.2%) eyes underwent XEN+cataract surgery and 40 (26.8%) XEN alone surgery. Mean medicated IOP was 20.0±7.1 at baseline and 13.9±4.3 mm Hg at 1 year (P<0.01), a 31% IOP reduction. Mean medications dropped from 1.9±1.3 preoperatively to 0.5±0.8 at 1 year (P<0.001). In total, 62.1% of patients achieved a ≥20% IOP reduction; this proportion was higher in the XEN alone group. 57.7% of eyes achieved complete success (without any antiglaucoma medications) and 71.1% qualified success (with or without medications) when IOP<16 mm Hg was considered as the definition of success. In all, 37% of patients required needling intervention. Adverse effects included bleb revision in 5 eyes, choroidal detachment in 2 eyes, and second glaucoma surgery in 9 eyes.

Conclusions:
The XEN gel implant as a standalone procedure or combined with cataract surgery demonstrated safe and sustained IOP reduction after 1 year.
Reflections on 50 Years of Neuroscience Nursing: Movement Disorders, Neuromuscular Disease, and Multiple Sclerosis
Authors: Woods Jennifer M. 
Published: December 2017

ABSTRACT
The American Association of Nursing was established in 1968 to support and advance the art and science of neuroscience nursing. During the course of 50 years, the Journal of Neuroscience Nursing has published numerous articles detailing the advances in the treatments of neurologic disease. The following highlights the strides achieved in the management of Parkinson disease, neuromuscular disease, and multiple sclerosis (MS).
Association of Magnet Status and Nurse Staffing With Improvements in Patient Experience With Hospital Care, 2008–2015
Authors: Zhu Junya , Dy Sydney M. , Wenzel Jennifer , Wu Albert W. 
Published: December 2017

Background:
Little is known about the longitudinal association of hospital Magnet status (an indicator of nursing excellence) and nurse-staffing level with inpatient care experience.

Objectives:
To examine temporal trends in hospital performance on patient experience measured using the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey and the association of these trends with Magnet status and nurse-staffing level.

Research Design:
Longitudinal study of hospital-level data from the HCAHPS survey, the American Hospital Association Annual Survey, and the American Nurses Credentialing Center. Growth curve models were used for the analysis of longitudinal associations.

Subjects:
A total of 26,752 hospital-year observations from 3614 US hospitals that collected at least 3 years of HCAHPS data from patients discharged between 2008 and 2015.

Measures:
Dependent variables were 7 HCAHPS measures. Independent variables included linear and quadratic time terms, hospital Magnet status, and nurse-staffing level.

Results:
There were significant improvements (P<0.001) in all 7 HCAHPS measures, but the trends were nonlinear; the improvement rates have decreased over time. Magnet hospitals and hospitals with more favorable nurse staffing consistently performed better on HCAHPS but did not improve faster than other hospitals during the study period. In subgroup analyses, HCAHPS scores did not improve for hospitals after they received Magnet recognition during the period from 2009 to 2015.

Conclusions:
The hospital organizational attributes that lead to Magnet recognition or better nurse staffing may be associated with higher performance on HCAHPS. Magnet status and favorable nurse staffing may be markers of hospital commitment to better patient-centered care.
The Association of Patient-centered Medical Home Designation With Quality of Care of HRSA-funded Health Centers
Authors: Hu Ruwei , Shi Leiyu , Sripipatana Alek , Liang Hailun , Sharma Ravi , Nair Suma , Chung Michelle , Lee De-Chih 
Published: December 2017

Objectives:
(1) To evaluate the relationship between Patient-centered Medical Home (PCMH) recognition and quality of clinical care among health centers, and (2) to determine whether the duration of recognition is positively associated with cumulative quality improvement over time.

Methods:
Data came from the 2012 to 2015 Uniform Data System, health centers’ PCMH recognition status, and the Area Resource File. Health center was the unit of observation. The outcome variables included 11 measures of clinical quality. We pooled all years of data and modeled longitudinal data with generalized estimating equations to examine the degree of improvement in health care quality in health centers with and without PCMH recognition over the years 2012–2015.

Results:
Health centers with PCMH recognition generally performed better on clinical quality measures than health centers that did not have PCMH recognition for all years studied. After accounting for health center and county-level potential confounders, health centers with longer periods of PCMH recognition were more likely to have improved their clinical quality on 9 of 11 measures, than health centers with fewer years of PCMH recognition.

Conclusions:
Health centers’ length of time with PCMH recognition was positively associated with additive quality improvement. Adoption of the PCMH model of care may serve as a strategy to enhance quality of primary care services.
Skin Rejuvenation through HIF-1α Modulation
Authors: Pagani Andrea , Aitzetmüller Matthias M. , Brett Elizabeth A. , König Viktoria , Wenny Raphael , Thor Dominik , Radtke Christine , Huemer Georg M. , Machens Hans-Günther , Duscher Dominik 
Published: December 2017

Summary:The constant intrinsic and extrinsic stress the skin is exposed to leads to significant impairments of the regenerative capacity of aging skin. Current skin rejuvenation approaches lack the ability to holistically support the biological processes that exhaust during aging skin degeneration, such as collagen production, cell migration and proliferation, and new vessel formation. Similar to chronic wounds, aged skin is characterized by dysfunction of key cellular regulatory pathways impairing regeneration. Recent evidence suggests that the same mechanisms hindering a physiologic healing response in chronic wounds are the basis of impaired tissue homeostasis in aged skin. Dysfunction of a main response-to-injury pathway, the hypoxia-inducible factor (HIF)-1α regulatory pathway, has been identified as pivotal both in chronic wounds and in aging skin degeneration. HIF-1α signaling is significantly involved in tissue homeostasis and neovascularization, resulting in the production of new collagen, elastin, and nourishing blood vessels. Modulating the functionality of this pathway has been demonstrated to significantly enhance tissue regeneration. In this review, we present an overview of the regenerative effects linked to the up-regulation of HIF-1α functionality, potentially resulting in skin rejuvenation on both the cellular level and the tissue level.
Xenomai-based multiple-process system, for real-time data acquisition and graphical display control
Authors: Caron Hadrien , Pouget Pierre 
Published: December 2017

AbstractTo elicit complex and rich graphical displays, and record neuronal phenomena ofinterest while all simultaneously being capable to interact in a closed-loop with external devises is a challenging task to all neurophysiologists. To facilitate this process, we have developed an Open-Source software system using a single computer running a well established Linux architecture (Ubuntu) associated to a kernel duo providing hard real-time support (Xenomai). We show that a single computer using our API is capable, for any tasks that require OpenGL displaying, to acheive millisecond accuracy programmed events. In this report, we describe the design of our system, benchmark and its performance in a real-world setting, and describe some key features.
NanoPack: visualizing and processing long read sequencing data
Authors: De Coster Wouter , D’Hert Svenn , Schultz Darrin T. , Cruts Marc , Van Broeckhoven Christine 
Published: December 2017

AbstractSummary: Here we describe NanoPack, a set of tools developed for visualization and processing of long read sequencing data from Oxford Nanopore Technologies and Pacific Biosciences.Availability and Implementation: The NanoPack tools are written in Python3 and released under the GNU GPL3.0 Licence. The source code can be found at https://github.com/wdecoster/nanopack, together with links to separate scripts and their documentation. The scripts are compatible with Linux, Mac OS and the MS Windows 10 subsystem for linux and are available as a graphical user interface, a web service at http://nanoplot.bioinf.be and command line tools.Contact:wouter.decoster@molgen.vib-ua.beSupplementary information: Supplementary tables and figures are available at Bioinformatics online.