bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research at the Marketing Interface to Advance Entrepreneurship Theory
Authors: Hills Gerald E. , Laforge Raymond W. 
Published: January 2018

The knowledge base for the emerging field of entrepreneurship should be interfunctional and interdisciplinary. Yet the functional discipline of marketing has contributed to the entrepreneurship field in only recent years. And entrepreneurship researchers and writers often address marketing superficially, without an awareness of sophisticated marketing concepts and methods. The objectives of this article are to identify key tangencies at the marketing/entrepreneurship interface, to provide relevant research sources, and to selectively convey illustrative marketing knowledge. Because length constraints prevent In-depth attention to any subject, breadth over depth is our objective. There are three major sections in this paper. First, the marketing/entrepreneurship interface is defined, with attention to various schools of marketing thought and their potential value to the entrepreneurship field. Secondly, unique tangencies with the buyer behavior literature are discussed and venture ideas and their evaluation (product research) are highlighted. Finally, the marketing strategy literature is reviewed as it potentially contributes to new venture development. In addition, other Important interfaces are briefly discussed.
Evaluation of a Serum Lung Cancer Biomarker Panel
Authors: Mazzone Peter J , Wang Xiao-Feng , Han Xiaozhen , Choi Humberto , Seeley Meredith , Scherer Richard , Doseeva Victoria 
Published: January 2018

Background: A panel of 3 serum proteins and 1 autoantibody has been developed to assist with the detection of lung cancer. We aimed to validate the accuracy of the biomarker panel in an independent test set and explore the impact of adding a fourth serum protein to the panel, as well as the impact of combining molecular and clinical variables. Methods: The training set of serum samples was purchased from commercially available biorepositories. The testing set was from a biorepository at the Cleveland Clinic. All lung cancer and control subjects were >50 years old and had smoked a minimum of 20 pack-years. A panel of biomarkers including CEA (carcinoembryonic antigen), CYFRA21-1 (cytokeratin-19 fragment 21-1), CA125 (carbohydrate antigen 125), HGF (hepatocyte growth factor), and NY-ESO-1 (New York esophageal cancer-1 antibody) was measured using immunoassay techniques. The multiple of the median method, multivariate logistic regression, and random forest modeling was used to analyze the results. Results: The training set consisted of 604 patient samples (268 with lung cancer and 336 controls) and the testing set of 400 patient samples (155 with lung cancer and 245 controls). With a threshold established from the training set, the sensitivity and specificity of both the 4- and 5-biomarker panels on the testing set was 49% and 96%, respectively. Models built on the testing set using only clinical variables had an area under the receiver operating characteristic curve of 0.68, using the biomarker panel 0.81 and by combining clinical and biomarker variables 0.86. Conclusions: This study validates the accuracy of a panel of proteins and an autoantibody in a population relevant to lung cancer detection and suggests a benefit to combining clinical features with the biomarker results.
Total Knee Arthroplasty: Does Day of Surgery Matter?
Authors: Malik Azeem Tariq , Khan Shahid , Ali Arif , Mufarrih Syed Hamza , Noordin Shahryar 
Published: January 2018

Introduction: There has been an influx of research studies aimed at identifying all factors that contribute to minimizing cost and maximizing postoperative care after total knee arthroplasty (TKA). Length of stay (LOS) has been defined as a significant factor that contributes to increased burden. We aimed at looking whether day of surgery has any significant effect on the LOS and postoperative complications following total knee arthroplasty (TKA). Materials and methods: Retrospective cohort study done at the Aga Khan University Hospital, Pakistan, from January 2007 to December 2015. A total of 611 patients who underwent a unilateral or bilateral total knee arthroplasty (TKA) were included in study: 269 (44.0%) patients underwent unilateral TKA and 342 (56.0%) underwent a bilateral TKA. Results: Kruskal-Wallis test and post hoc pairwise comparisons showed that unilateral TKAs performed on Tuesday, Saturday, and Sunday resulted in a lower median LOS ( P < .05). No significant association was seen in bilateral TKA group. Day of surgery was not associated with postoperative complications. Conclusions: Unilateral TKAs performed earlier during the week and later on the weekend are associated with a significantly lower LOS. It is highly probable that patch ancillary services during the latter part of the week and a higher workload for the staff are important reasons for this phenomenon.
First Experiences With a Wearable Multisensor in an Outpatient Glucose Monitoring Study, Part I: The Users’ View
Authors: Caduff Andreas , Zanon Mattia , Zakharov Pavel , Mueller Martin , Talary Mark , Krebs Achim , Stahel Werner A. , Donath Marc 
Published: January 2018

Background: Extensive past work showed that noninvasive continuous glucose monitoring with a wearable Multisensor device worn on the upper arm provides useful information about glucose trends to improve diabetes therapy in controlled and semicontrolled conditions. Methods: To test previous findings also in uncontrolled in-clinic and outpatient conditions, a long-term study has been conducted to collect Multisensor and reference glucose data in a population of 20 type 1 diabetes subjects. A total of 1072 study days were collected and a fully on-line compatible algorithmic routine linking Multisensor data to glucose applied to estimate glucose trends noninvasively. The operation of a digital log book, daily semiautomated data transfer and at least 10 daily SMBG values were requested from the patient. Results: Results showed that the Multisensor is capable of indicating glucose trends. It can do so in 9 out of 10 cases either correctly or with one level of discrepancy. This means that in 90% of all cases the Multisensor shows the glucose dynamic to rapidly increase or at least increase. Conclusions: The Multisensor and the algorithmic routine used in controlled conditions can track glucose trends in all patients, also in uncontrolled conditions. Training of the patient proved to be essential. The workload imposed on patients was significant and should be reduced in the next step with further automation. The feature of glucose trend indication was welcomed and very much appreciated by patients; this value creation makes a strong case for the justification of wearing a wearable.
Recent advances of the signal processing techniques in future smart grids
Authors: Uddin Zahoor , Ahmad Ayaz , Qamar Aamir , Altaf Muhammad 
Published: January 2018

AbstractSmart grid is an emerging research field of the current decade. The distinguished features of the smart grid are monitoring capability with data integration, advanced analysis to support system control, enhanced power security and effective communication to meet the power demand. Efficient energy consumption and minimum costs are also included in the prodigious features of smart grid. The smart grid implementation requires intelligent interaction between the power generating and consuming devices that can be achieved by installing devices capable of processing data and communicating it to various parts of the grid. The efficiency of these devices is greatly dependent on the selection and implementation of the advance digital signal processing techniques. This paper provides a comprehensive survey on the applications of signal processing techniques in smart grids, plus the challenges and shortcomings of these techniques. Furthermore, this paper also outlines some future research directions related to applications of signal processing in smart grids.
Numerical simulation of the in situ stress in a high-rank coal reservoir and its effect on coal-bed methane well productivity
Authors: Yin Shuai , Li Airong , Jia Qiang , Ding Wenlong , Li Yanxia 
Published: January 2018

In situ stress has an important influence on coal reservoir permeability, fracturing, and production capacity. In this paper, fracturing testing, imaging logging, and 3D finite-element simulation were used to study the current in situ stress field of a coal reservoir with a high coal rank. The results indicated that the horizontal stress field within the coal reservoir is controlled by the burial depth, folding, and faulting. The [Formula: see text] and [Formula: see text] values within the coal reservoir are 1–2.5 MPa higher than those within the clastic rocks of the roof and floor. The [Formula: see text]–[Formula: see text] values of the coal reservoir are generally between 2 and 6 MPa and increase with burial depth. When the [Formula: see text]–[Formula: see text] value is less than 5 MPa, production from a single well is high, but when the [Formula: see text]–[Formula: see text] value is greater than 5 MPa, production from a single well is low. In addition, the accumulated water production is high when the [Formula: see text]–[Formula: see text] value is greater than 5 MPa, demonstrating that a higher [Formula: see text]–[Formula: see text] value allows the hydraulic fractures to more easily penetrate the roof and floor of the coal seam. In coal-bed methane development regions with high [Formula: see text]–[Formula: see text] values, repeated fracturing using the small-scale plug removal method — which is a fracturing method that uses a small volume of liquid, small displacement, and low sand concentration — is suggested.
The Political Life of Cancer
Authors: Kelley Lindsay 
Published: January 2018

Abstract
One of the late Beatriz da Costa’s last projects, Dying for the Other (2011), presents three channels of video footage from testing environments, including laboratories, hospitals, kitchens, and living rooms offset by pink mice wriggling in their cage, living and dead mice weighed and handled by breast cancer researchers, and the materials of laboratory and medical work: test tubes, petri dishes, scalpels. Together across three shared video channels, bald pink mice have materially moved into da Costa’s frail body through a deft game of pharmacological cat’s cradle. This article will investigate da Costa’s Dying for the Other and a related project, the Anti-cancer Survival Kit (2013), as engagements with Elizabeth Wilson’s articulation of the gut as “an organ of mind.” Figuring the eating body as ecosystem illuminates how cancer’s political potential furthers both Wilson’s desire for “sustained attention [to] the nature of attacking, sadistic impulses, and the difficulties of how to live (and politick) with them” and Scott Gilbert, Jan Sapp, and Alfred Tauber’s call for “intermingled symbiont relationships.” The multispecies power structures playing out in Dying for the Other and the Anti-cancer Survival Kit reveal the political life of cancer to be animated by cellular and culinary anarchisms, bile, toxicity, frustration, and, in da Costa’s words, “more than even I can take.”
Astrobiology and the Ultraviolet World
Authors: Praet Istvan 
Published: January 2018

AbstractAstrobiology is normally envisaged as the scientific endeavor preoccupied with the search for life beyond Earth. What remains underappreciated, however, is that it is also a hotbed of transversal thinking. It links disciplines that have historically grown up in isolation from each other—such as solar physics, atmospheric science, dermatology, and ophthalmology (eye biology)—in remarkable ways. And even though these links may cast new light on the question of extraterrestrial life, they are an interesting topic of study in their own right. The present study illustrates this ethnographically, by using the angle of ultraviolet. Specifically, I focus on the ultraviolet spectrum to examine how astrobiologists look at celestial bodies, planetary atmospheres, the skin, and the eye. More generally, this article is a reflection on how outer space can be apprehended from a humanities perspective.
Preparing for Catastrophe on the Polar Frontier
Authors: O’reilly Jessica 
Published: January 2018

Abstract
From a distance, Antarctica invokes extreme imaginaries and possibilities. In the practice of everyday human Antarctic life, however, daily tasks and risks are heavily managed, mitigated, and overseen. To analyze the spectacular and mundane natures of human life in Antarctica, I will compare the paramilitary practicalities of Antarctic research station and field camp life with the visions of the Antarctic as a place of sublime wild nature, violent death, and climate disaster. Using three signature events in Antarctic field training—predeparture, orientation, and navigation—I consider how people visiting the Antarctic are trained to order their lives and work, especially in preparation for emergencies. Notions of risk, danger, and catastrophe hinge on the broader historical and cultural contexts of Antarctica as a frontier zone, making preparedness in the Antarctic gendered, militaristic, and highly ritualized. Finally, I compare climate catastrophe at a global scale—the other sort and scale of emergency Antarctic people are occupied with—with how traditional field preparedness maps onto this potential disaster. In field training, Antarctic people counter the tropes of wild nature with extreme and exaggerated performances of bureaucracy; this analysis, then, considers the generative potential of technocratic practices in the face of the Anthropocene, an environmental expression of human triumph and disaster. Practicing risk management requires practices of embodiment as well as literal and figurative orientations to potential hazards.
Pre-hospital delay in Vietnamese patients hospitalized with a first acute myocardial infarction: A short report
Authors: Nguyen Hoa L. , Phan Dat T. , Ha Duc A. , Nguyen Quang N. , Goldberg Robert J. 
Published: January 2018

Background: Administration of coronary reperfusion therapy to patients with an acute myocardial infarction (AMI) within the proper timeframe is essential in avoiding clinical complications and death. However, the extent of pre-hospital delay is unexplored in Vietnam. This report aims to describe the duration of pre-hospital delay of Hanoi residents hospitalized with a first AMI at the Vietnam National Heart Institute . Methods: A total of 103 Hanoi residents hospitalized at the largest tertiary care medical center in the city for first AMI, who have information on prehospital delay was included in this report.Results: One third of the study sample was women and mean age was 66 years. The mean and median pre-hospital delay duration were 14.9 hours and 4.8 hours, respectively. The proportion of patients who delayed <6 , 6-<12, and ≥ 12 hours were 45%, 13%, and 42%, respectively.Conclusions: Our data shows that a prolonged pre-hospital delay is often observed in patients with a first AMI in Vietnam. In order to confirm these preliminary descriptive findings, a full-scale investigation of all Hanoi residents hospitalized with first AMI is needed. Increasing public awareness about AMI treatment is vital in encouraging patients to seek medical care timely after experiencing AMI symptoms such that received treatment is most effective.
Variation in the effectiveness of insecticide treated nets against malaria and outdoor biting by vectors in Kilifi, Kenya
Authors: Kamau Alice , Mwangangi Joseph M. , Rono Martin K. , Mogeni Polycarp , Omedo Irene , Midega Janet , Scott J. Anthony G. , Bejon Philip 
Published: January 2018

Background: Insecticide treated nets (ITNs) protect humans against bites from the Anopheles mosquito vectors that transmit malaria, thereby reducing malaria morbidity and mortality. It has been noted that ITN use leads to a switch from indoor to outdoor feeding among these vectors. It might be expected that outdoor feeding would undermine the effectiveness of ITNs that target indoors vectors, but data are limited. Methods: We linked homestead level geospatial data to clinical surveillance data at a primary healthcare facility in Kilifi County in order to map geographical heterogeneity in ITN effectiveness and observed vector feeding behaviour using landing catches and CDC light traps in six selected areas of varying ITN effectiveness. We quantified the interaction between mosquitoes and humans to evaluate whether outdoor vector biting is a potential explanation for the variation in ITN effectiveness. Results: We observed 37% and 46% visits associated with positive malaria slides among ITN users and non-ITN-users, respectively; ITN use was associated with 32% protection from malaria (crude OR = 0.68, 95% CI: 0.64, 0.73). We obtained significant modification of ITN effectiveness by geographical area (p=0.016), and identified significant hotspots using the spatial scan statistic. Majority of mosquitoes were caught outdoor (60%) and were of the An. funestus group (75%). The overall propensity to feed at times when most people are indoor was high; the vast majority of the Anopheles mosquitoes were caught at times when most people are indoor. Estimates for the proportion of human-mosquito contact between the first and last hour when most humans were indoor was consistently high, ranging from 0.83 to 1.00. Conclusion: Our data therefore do not support the hypothesis that outdoor biting limits the effectiveness of ITNs in our study area.
Hyperspectral imaging of tissue perfusion and oxygenation in wounds: assessing the impact of a micro capillary dressing
Authors: Wild Thomas , Becker Markus , Winter Jochen , Schuhschenk Nicole , Daeschlein Georg , Siemers Frank 
Published: January 2018

Objective: Experimental tests of non-invasive multi- or hyperspectral imaging (HSI) systems reveal the high potential of support for medical diagnostic purposes and scientific biomedical analysis. Until now the use of HSI technologies for medical applications was limited by complex and overly sophisticated systems. We present a new and compact HSI-camera that could be used in normal clinical practice. Method: We assessed the use of the HSI system on the hands of 10 healthy volunteers, looking at control parameters, and those following venous occlusion, arterial occlusion and reperfusion, including tissue oxygenation, tissue haemoglobin index, perfusion in 4–6mm depth=near infrared spectroscopy (NIR), and tissue water index. Pseudo colours used ranged from 0% (blue) to 100% (red). We also assessed differences in the wounds of three patients. Results: The results show good potential in all parameters in the healthy volunteers, which had high conformity with validated reference oximetry measurements. In three wounds, different levels of oxygenation were identified in the wound area, although interpretation of these results is complex. In Cases 2 and 3, following the application of a micro capillary dressing, improvements were seen in perfusion and reduction of the tissue water index (TWI). Conclusion: The camera system proved to be quick, flexible and yielded data with high spatial and spectral resolution. These data will be used to perform a power analysis for a randomised controlled study.
Cytotoxic Activity on MCF-7 Cells and in Silico Study of Sapogenin Steroids From Trigonella foenum-graecum L.
Authors: Agustini Kurnia , Firdayani Firdayani , Churiyah Churiyah 
Published: January 2018

Trigonella foenum-graecum (TFG) is one of medicinal plants containing several steroidal sapogenins, such as diosgenin, yamogenin, gitogenin, tigogenin and trigoneoside, and also alkaloid trigonellin and some flavonoids such as vitexin, isovitexin, orientin, isoorientin, which has many activities, such as antidiabetic, estrogenic, and also anticancer. As phytoestrogen, TFG was predicted to have potency as Selective Estrogen Receptor Modulators (SERMs) which is used for hormonal-dependent breast cancer treatment. This experiment was carried out to investigate interaction of some sapogenin steroids and flavonoids in TFG to estrogen receptor alpha (ERα) and its activity to breast cancer cell line as confirmation. In silico prediction was carried out to investigate their estrogenic activity by analyzing their binding affinity to ERα using AutoDock Vina program. In vitro activity confirmation of TFG extract and its fractions were carried out using MTT assay on Erα-positive human breast cancer cell line, MCF-7. Results showed that free binding energies of diosgenin and yamogenin were -6.4 kcal/mol, estradiol was -6.0 kcal/mol, and tamoxifen was -5.1 kcal/mol. While cytotoxicity assay showed that ethyl acetate fraction gave the lowest IC50 of 41.81 ppm, with total steroid content of 20.03 ppm. From these results, we can conclude that diosgenin and yamogenin have greater binding affinity to ERα comparing to estradiol and tamoxifen. In vitro assay confirmation showed that ethyl acetate fraction has cytotoxic effect on MCF-7 cells.Keywords: Trigonella foenum-graecum, sapogenin steroids, MCF-7, estrogen receptor alpha, binding affinity
SMEDDS of Citrus hystrix ethanolic extract improves cardiac and hepar histopathology profile on doxorubicin-induced rats
Authors: Novitasari Dhania , Tirtanirmala Prisnu , Wulandari Nindi , Wikanthi Layung Sekar Sih , Safitri Ade , Sasmito Ediati 
Published: January 2018

Citrus hystrix D.C. (kaffir lime) peel contains several flavonoids including rutin, naringenin, hesperidin. C. hystrix peel ethanolic extract (ChEE) has shown its potency as cardioprotector agent in chemotherapy. However, there are limitations to the utilization of ChEE due to its poor water solubility and low oral bioavailability. Accordingly, self-microemulsifying drug delivery system (SMEDDS) formulations were developed to improve the oral absorption of flavonoids. Tween 80, Corn oil, and propylene glicol (5:1:1ml) were combined to form ChEE-SMEDDS. The present study is to evaluated ChEE-SMEDDS for their physicochemical properties and in vivo using combination with doxorubicin to see blood serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), nitrit oxide (NO) activity and also cardio-hepato-histopathology of female Sprague Dawley rats. The results showed that ChEE-SMEDDS repaired cardio-hepato-histopathology profile of doxorubicin -induced rats, but did not reduce serum activity of NO, ALT and AST. These results indicated that ChEE-SMEDDS has potency to be developed and improved as cardio-hepato-protector agent in chemotherapy.Keywords: Citrus hystrix D.C., SMEDDS, Cardio-hepatoprotector, Histopathology, Chemoterapy