bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parque temático turístico cultural como alternativa de diversificación de la oferta turística en la ciudad de Santa Elena.
Authors: Freire Rendón Mercedes , Peralta Silvia , Mendoza Efrén , Linzán Jessica 
Published: June 2017

El turismo de sol y playa es el segmento que genera mayor flujo de turistas y representa un motor importante para el desarrollo de la actividad en muchos países. Sin embargo, el hacinamiento, el deterioro ambiental, los cambios en la demanda y el aumento de la competencia han generado preocupación por el futuro de los destinos consolidados de sol y playa. Dada esta afirmación, y siendo Santa Elena una localidad con estas características, se hace relevante buscar alternativas de diversificación de la oferta turística que permitan dinamizar procesos de desarrollo sostenible del sector. El Objetivo de esta investigación, consiste en determinar el parque temático turístico cultural como alternativa de diversificación de la oferta turística en la ciudad de Santa Elena. La metodología utilizada se basó en un enfoque cualitativo-cualitativo apoyado en la recolección de datos con el diseño de entrevistas en profundidad con actores comunitarios como informantes clave para determinar las categorías a evaluar y establecer elementos esenciales del diagnóstico. Los principales resultados determinaron que en la ciudad de Santa Elena a pesar de la existencia del museo Amantes de Sumpa con enfoque cultural no hay lugar o atracción turística con temática que relacione lo recreativo y cultural, representando costumbres y tradiciones locales para la satisfacción de los visitantes. AbstractThe tourism of sun and beach is the segment that generates greater flow of tourists and represents an important motor for the development of the activity in many countries. However, overcrowding, environmental deterioration, changes in demand and increased competition have generated concern about the future of consolidated sun and beach destinations. Given this assertion, and being Santa Elena a locality with these characteristics, it becomes relevant to look for alternatives of diversification of the tourist supply that allow to dynamize processes of sustainable development of the sector. The objective of this research is to determine the cultural tourism theme park as an alternative to diversify tourism in the city of Santa Elena. The methodology used was based on a qualitative-qualitative approach based on the collection of data with the design of in-depth interviews with community actors as key informants to determine the categories to be evaluated and to establish essential elements of the diagnosis. The main results determined that in the city of Santa Elena despite the existence of the museum Lovers of Sumpa with cultural focus there is no place or tourist attraction with thematic that relates the recreational and cultural, representing customs and local traditions for the satisfaction of the visitors.
Zu wenig Waldverjüngung? Mit mehr Waldbewirtschaftung und Jagd zum Erfolg (Essay)
Authors: Frei Maurus 
Published: June 2017

Not enough forest regeneration? Intensified silviculture and hunting bring success (essay)
The influence of red deer, roe deer and chamois on forest regeneration is significant in Swiss forests, especially in mountain forests. Oak, silver fir and sycamore rarely regenerate without protection measures. Red deer populations have practically doubled over the last 20 years, and roe deer are found in every forest. Nevertheless, it is possible to have, even in Switzerland, a dense, site-appropriate forest regeneration. The conditions for this are close-to-nature silviculture over large areas, and hunting which is closely adapted to the condition of the forest. This approach is successful if it is accompanied by serious cooperation between forest services and hunters – a cooperation which is not seen as an end in itself but as a means of reaching agreed objectives. Success will not be achieved with compromises only and by following traditional approaches.
Le destin de l’anatomie
Authors: Laqueur Thomas , Chalier Jonathan 
Published: June 2017

L’historien américain de la sexualité explique que le corps naturel change selon les différentes manières de le décrire : c’est le destin qui fait l’anatomie. La période contemporaine est marquée par l’idéal d’un corps sur mesure pour chacun selon son identité sexuelle.
Targeting the β‐clamp in Helicobacter pylori with FDA‐approved drugs reveals micromolar inhibition by diflunisal
Authors: Pandey Preeti , Verma Vijay , Gautam Gunjan , Kumari Nilima , Dhar Suman Kumar , Gourinath Samudrala 
Published: June 2017

The β‐clamp is the processivity‐promoting factor for most of the enzymes in prokaryotic DNA replication; hence, it is a crucial drug target. In the present study, we investigated the β‐clamp from Helicobacter pylori, aiming to seek potential drug molecules against this gastric‐cancer‐causing bacterium. An in silico screening of Food and Drug Administration (FDA) approved drugs against the H. pylori β‐clamp, followed by its in vitro inhibition using a surface competition approach, yielded the drug diflunisal as a positive initial hit. Diflunisal inhibits the growth of H. pylori in the micromolar range. We determined the structure of diflunisal in complex with the β‐clamp to show that the drug binds at subsite I, which is a protein–protein interaction site. Successful identification of FDA‐approved molecules against H. pylori may lead to better and faster drug development.
Information capitalism
Authors: Ignatow Gabe 
Published: June 2017

Abstract

Information capitalism refers to the increasing importance of information within capitalism under conditions of globalization and rapid technological development. The idea of “information capitalism” is closely related to similar concepts such as
knowledge economy
(Drucker [1969] 1992),
postindustrial society
(Touraine 1971; Bell [1973] 1976),
information society
(Webster 2002), and
network society
(Castells 2000).
Tuning 2D Light Upconversion Emission by Modulating Phonon Relaxation
Authors: Kim Bum Jin , Lim Soo Yeong , Cho Youngho , Nam Sang Hwan , Suh Yung Doug , Park Chan Ryang , Kim Hyung Min 
Published: June 2017

AbstractThe photonic upconversion in rare earth atoms is widely used to convert “invisible” near infrared photons to “visible” photons with continuous wave light. By using a patterned substrate, upconversion become a route for creating new information‐incorporating security codes. The amount of information in the cipher increases in proportion to the number of emission colors as well as the pattern structure. Subsequently, changing the chemical composition of upconversion phosphors on 2 D substrates is required to manufacture information‐rich upconversion cryptography. In this study, we exploited temperature‐controlled thermal reaction on upconversion films deposited on a quartz substrate to prepare security information codes. Multiple color emission was generated from upconversion films as the result of inserting high‐frequency molecular oscillators into the film structures. Fourier‐transform infrared (FTIR) and time‐resolved study corroborated the mechanism of spectral variation of upconversion films.
Is it safe to use lamotrigine during pregnancy? A prospective comparative observational study
Authors: Diav‐Citrin Orna , Shechtman Svetlana , Zvi Naama , Finkel‐Pekarsky Victoriya , Ornoy Asher 
Published: June 2017

BackgroundLamotrigine is a second‐generation antiepileptic drug, also used as a mood stabilizer. Published data on its use in human pregnancy are largely derived from pregnancy registries. Pregnancy experience in most studies has been reassuring. However, data from the North American Antiepileptic Drug Pregnancy Registry suggested an increased risk for oral clefts. The primary objective of the study was to evaluate the rate of major anomalies after lamotrigine exposure during pregnancy compared with pregnancies of women counseled for nonteratogenic exposure (NTE).MethodsCallers who contacted the Israeli Teratology Information Service regarding lamotrigine treatment or NTE during pregnancy between 1997 and 2008 were prospectively followed‐up.ResultsThe rate of major congenital anomalies was similar between 218 lamotrigine exposed pregnancies (208 in the first trimester) and 865 NTE‐pregnancies. There was no case of oral cleft in the lamotrigine‐exposed group. The median lamotrigine dose in the beginning of pregnancy was 200 mg/d. The dose was increased during pregnancy in 29%. The majority of women in the cohort (82%) were treated for neurologic indications, while 18% for psychiatric disorders. Monotherapy was taken by 72%.ConclusionThe data available, thus far, on lamotrigine monotherpy‐exposed pregnancies are encouraging. However, further studies are needed to determine with greater certainty the overall risk for major anomalies, as well as the specific risk for oral clefts. Based on the current and previously published data, lamotrigine, seems a reasonable alternative for pregnant women when clinically indicated. Birth Defects Research 109:1196–1203, 2017. © 2017 Wiley Periodicals, Inc.
Management of common variable immunodeficiency by subcutaneous IgG self‐administration during pregnancy – a case report
Authors: Marasco Carolina , Venturelli Alberta , Rao Luigia , Vacca Angelo , Carratù Maria Rosaria 
Published: June 2017

Key Clinical MessagePatients with common variable immunodeficiency are prone to infections, and this poses a particular challenge during pregnancy, when the requirement for immunoglobulin (Ig) replacement therapy is even more demanding so as to achieve an effective protection also of the fetus. This case report highlights the benefits observed with subcutaneous IgG self‐administration in the management of common variable immunodeficiency (CVID) during pregnancy, in terms of efficacy and safety.
Temporal fish community responses to two cascade run‐of‐river dams in the Madeira River, Amazon basin
Authors: Cella‐Ribeiro Ariana , da Costa Doria Carolina Rodrigues , Dutka‐Gianelli Jynessa , Alves Hellison , Torrente‐Vilara Gislene 
Published: June 2017

AbstractWe examined responses from shore fish assemblages and bottom channel fish assemblages before and after 2 cascade run‐of‐river dams in the Madeira River, in the Amazon. Those dams were installed in a river corridor where historical factors, represented by the presence of the Teotônio and Jirau falls, were the best predictors of the fish fauna assemblage composition. Jirau and Santo Antônio were the first dams constructed with Kaplan horizontal bulb turbines in the Amazon. These bulb turbines have the ability to operate by forming small reservoirs known as run‐of‐river, which should minimize impacts on fish assemblages. Overall, there were major short‐term impacts in shore fish assemblages by increasing species richness, abundance, and biomass in experimental catches. Shore fish assemblages dissimilarities before and after the dams' closure were also noticed and were related to an increase in water temperature and dissolved oxygen. However, the historical factor represented by Teotônio Fall is still the best predictor of fish assemblage dissimilarities, combined with effects of dams' closure. Bottom channel fish assemblage dissimilarities can be explained only by dams closure and are related especially to changes in fish species abundance inside the reservoirs. Our study revealed an increase in native opportunistic fish species and changes in fish assemblage structure at local scale. Kaplan horizontal bulb turbines employed in run‐of‐river dams seem to be less deleterious than vertical axis turbines typically used in accumulation reservoirs, and should be preferred in the face of burgeoning new hydroelectricity development plans for rivers across the Amazon basin.
New York State Breast Density Mandate: Follow‐up Data With Screening Sonography
Authors: Destounis Stamatia , Arieno Andrea , Morgan Renee 
Published: June 2017

ObjectivesTo evaluate the impact on breast cancer detection from screening breast sonography performed in women with mammographically dense breasts.MethodsThis study used a retrospective chart review. Data collected included total number of screening mammograms, total number of dense breast screening sonograms, total number of procedures performed, biopsy results, and demographic data. Data were obtained from January 1, 2013, through August 31, 2015. During this period, there were a total of 195,982 screening mammographic examinations performed at our facility. Of these, 83,234 patients (42.5%) were informed that their breast tissue was heterogeneously dense or extremely dense. We specifically reviewed cases to identify those with findings on sonography only. The positive predictive value, biopsy rate, and cancer detection rate were determined.ResultsDuring the study period, 5434 screening sonographic examinations were performed in 4898 women with heterogeneously dense or extremely dense breasts. Most (95.7%) of the sonographic examinations resulted in an American College of Radiology Breast Imaging Reporting and Data System (BI‐RADS) category 1 or 2 designation. A total of 101 lesions were given a BI‐RADS 3 designation; 134 suspicious findings were given a BI‐RADS 4 or 5 designation; and 100 of these were seen on sonography only, all of which underwent tissue sampling, resulting in the diagnosis of 18 malignancies; all were invasive. In evaluating screening sonographic findings, we found a positive predictive value of 18.0%, with an overall biopsy rate of 2.0% and a cancer detection rate of 3.3 per 1000.ConclusionsThe results of our continued evaluation of our screening sonography program confirm that screening breast sonography in women with dense breast tissue can detect otherwise occult malignancy, with a low biopsy rate.
Agro‐Waste Extract Based Solvents: Emergence of Novel Green Solvent for the Design of Sustainable Processes in Catalysis and Organic Chemistry
Authors: Sarmah Manashi , Mondal Manoj , Bora Utpal 
Published: June 2017

AbstractWater extract of agro‐waste ash (AWEs) has emerged as an efficient non‐conventional solvent for practicing green reactions in catalysis and organic chemistry. The recent advancements made in the field of agro‐waste‐derived reaction media have witnessed a major advancement in reactions like Suzuki‐Miyaura, Sonogashira, Dakin, Henry, peptide synthesis and ipso‐hydroxylation. Traditionally, these reactions were conducted in conventional volatile organic solvents (VOCs) derived from non‐renewable petroleum sources. During the course of these reactions AWEs displays distinct properties, such as, in situ base, homogeneous catalyst, nano reactor and reducing agent. This review summarizes the recent developments made in the application of AWEs in important reactions emphasizing on the key utilities and limitations in order to facilitate the further progress of this exciting area of research.
Synthesis of Carboxamide‐Functionalized Multiwall Carbon Nanotubes via Ugi Multicomponent Reaction: Water‐Dispersible Peptidomimetic Nanohybrid as Controlled Drug Delivery Vehicle
Authors: Shaabani Ahmad , Afshari Ronak 
Published: June 2017

AbstractThis paper describes a direct synthesis of novel and valuable carboxamide functionalized multiwall carbon nanotubes (carboxamide‐f‐MWCNTs) for the development of new nanovectors through covalent functionalization via a one‐pot four‐component Ugi reaction. This efficient synthetic approach is facile and straightforward procedure for the synthesis of peptidomimetic coated MWCNTs from simple and readily starting materials including aniline, benzaldehyde, isocyanide and the carboxylated MWCNT as an acid component. The new synthesized nanobiohybrid was fully characterized. Also, the stability of nanobiohybrid was assessed using Zeta potential and particle size analyses. The synthesized nanobiohybrid presents unprecedented high and long term dispersity and stability in water. The performance of the nanobiohybrid for the controlled release of folic acid, as a model drug, was investigated and the results depicted pH dependent slow drug release behavior of nanobiohybrid. In addition, biocompatibility and cytotoxicity of carboxamide‐f‐MWCNTs were examined and no obvious adverse effects on the viability of NIH‐3T3 cells were observed. The results manifested its valuable applicability in controlled release drug delivery systems.
Does E-cigarette Use at Baseline Influence Smoking Cessation Rates among 2-Year College Students?
Authors: Snow Erika , Johnson Tye , Ossip Deborah J. , Williams Geofrey C. , Ververs Duncan , Rahman Irfan , McIntosh Scott 
Published: June 2017

Introduction: This study evaluates the association of baseline e-cigarette use with smoking cessation in a sample of 2-year college student smokers.Methods: Participants were 1,400 students from over 60 2-year colleges across 25 states who were current smokers enrolled in a web-assisted tobacco intervention (WATI) trial. Survey data at baseline, 1-, and 6-months, were evaluated.Results: At 6-months, baseline e-cigarette users were more likely to report cessation of traditional cigarettes compared to non-users (OR 1.39, 95% CI 1.002–1.92). Cessation was also associated with higher baseline confidence in quitting and greater time to first cigarette after awakening. Baseline e-cigarette use was not associated with self-reported cessation of all nicotine/tobacco products (OR 1.09, 95% CI 0.75–1.58) nor biochemically verified cessation of all nicotine/tobacco products (OR 0.83, 95% CI 0.47–1.47). Higher confidence was again associated with both self-reported and biochemically verified cessation of all nicotines.
Dating the Remains of a Church in Lubin (Wolin Island, NW Poland) in Light of Archaeological and Radiocarbon Studies
Authors: Krąpiec Marek , Rębkowski Marian 
Published: June 2017

AbstractArchaeological excavations carried out from 2008 to 2011 at the Lubin stronghold (NW Poland) brought about the discovery of relics in one of the oldest Christian churches in Pomerania (NW Poland). Radiocarbon (14C) analysis of 24 samples of charred wood from the deposits within the stronghold pointed to a chronology spanning from the 10th to 13th centuries, which is consistent with the archaeological evidence. However, the 14C analysis of 12 samples collected from the destruction of the church (erected in 1124 AD according to written accounts) produced a chronology notably older than expected, with a recorded difference of no less than 100 yr. The most probable explanation for this discrepancy seems to be the secondary use of older timber during the construction of the church.
Knocking Down Walls in Political Science: In Defense of an Expansionist Feminist Agenda
Authors: MacDonald Fiona 
Published: June 2017

AbstractThis article offers one possible answer to the question “What is the future of feminist political science?” by outlining and defending an expansionist agenda that is centred on challenging the male-female binary that has been upheld and replicated in the discipline to date. Such an approach draws heavily on the insights of intersectional analyses, transgender, queer and gender-fluid articulations of identity and requires that the field of political science investigate the varied and complex gendered experiences of “men.” Overall, this article argues that such as expansionist agenda is key to responding to the interrelated challenges presented by the perceived “crisis” of feminism and the ongoing “masculinity” of the discipline of political science.
A scoping research literature review to assess the state of existing evidence on the “bad” death
Authors: Wilson Donna M. , Hewitt Jessica A. 
Published: June 2017

ABSTRACTObjective:A scoping research literature review on “bad death” was undertaken to assess the overall state of the science on this topic and to determine what evidence exists on how often bad deaths occur, what contributes to or causes a bad death, and what the outcomes and consequences of bad deaths are.Method:A search for English-language research articles was conducted in late 2016, with 25 articles identified and all retained for examination, as is expected with scoping reviews.Results:Only 3 of the 25 articles provided incidence information, specifying that 7.8 to 23% of deaths were bad and that bad deaths were more likely to occur in hospitals than in community-care settings. Many different factors were associated with bad deaths, with unrelieved pain being the most commonly identified. Half of the studies provided information on the possible consequences or outcomes of bad deaths, such as palliative care not being initiated, interpersonal and team conflict, and long-lasting negative community effects.Significance of results:This review identified a relatively small number of research articles that focused in whole or in part on bad deaths. Although the reasons why people consider a death to be bad may be highly individualized and yet also socioculturally based, unrelieved pain is a commonly held reason for bad deaths. Although bad and good deaths may have some opposing causative factors, this literature review revealed some salient bad death attributes, ones that could be avoided to prevent bad deaths from occurring. A routine assessment to allow planning so as to avoid bad deaths and enhance the probability of good deaths is suggested.
The German Feedback Socialization Inventory
Authors: König Nina , Puca Rosa Maria 
Published: June 2017

Abstract. Feedback after success and failure can refer to stable attributes like ability and personality traits (person feedback) or to variable attributes like effort and strategies (process feedback). Past experimental research has shown that person feedback leads to helpless reactions after failure, whereas process feedback fosters mastery reactions. Feedback given in experimental settings may, however, have other effects than feedback given in natural settings for a long time. In order to investigate the latter we constructed the German Feedback Socialization Inventory (FSI), which assesses parental feedback retrospectively. The FSI consists of nine subscales assessing different facets of person and process feedback after success and failure from the recipients’ point of view. Construction followed rational principles. The pilot version was examined by exploratory factor analyses and item analyses ( N = 214). Results led to a shortened version, whose factorial structure was confirmed by structural equation modeling in three independent samples ( N = 1,113). The FSI showed good psychometric properties in each sample. Furthermore, validation was successful with regard to parental rearing behavior, variables concerning school performance, parental level of education, and participants’ coping styles.
Polyaromatic molecular peanuts
Authors: Yazaki Kohei , Akita Munetaka , Prusty Soumyakanta , Chand Dillip Kumar , Kikuchi Takashi , Sato Hiroyasu , Yoshizawa Michito 
Published: June 2017

AbstractMimicking biological structures such as fruits and seeds using molecules and molecular assemblies is a great synthetic challenge. Here we report peanut-shaped nanostructures comprising two fullerene molecules fully surrounded by a dumbbell-like polyaromatic shell. The shell derives from a molecular double capsule composed of four W-shaped polyaromatic ligands and three metal ions. Mixing the double capsule with various fullerenes (that is, C60, C70 and Sc3N@C80) gives rise to the artificial peanuts with lengths of ∼3 nm in quantitative yields through the release of the single metal ion. The rational use of both metal–ligand coordination bonds and aromatic–aromatic π-stacking interactions as orthogonal chemical glue is essential for the facile preparation of the multicomponent, biomimetic nanoarchitectures.