bluuebunny/crossref_metadata_2025_split huggingface dataset:
Specific features of bilateral otolith manifestations in patients with vestibular balance disorder
Authors: Grebenuk O. V. , Svetlik M. V. , Alifirova V. M. , Demkin V. P. , Akinina M. D. , Melnichuk S. V. , Rudenko T. V. , Smaglii L. V. , Demkin O. V. , Vishnevskaya Ya. B. , Trukhanov A. E. 
Published: October 2024

Bilateral asymmetry in the function of the semicircular canals underlies dizziness and vestibular balance disorders. According to the traditional view, otolith dysfunction does not have a significant effect on the clinical picture in individuals with peripheral vestibular disorders. In recent years, interest in studying the contribution of vestibular function to the control of posture and movements has increased. However, we have not identified any studies addressing the reactivity of otolith organs in vestibular balance disorders in the available literature.Aim: To study bilateral otolith reactions in patients with vestibular balance disorders using the method of cervical vestibular evoked myogenic potentials (cVEMP) in patients with episodic and chronic vestibular disorders.Material and Methods. A clinical examination was carried out in 63 patients complaining of dizziness and balance problems. They were hospitalized on an emergency and planned basis in the neurological departments of the clinics of the Siberian State Medical University and the Medical and Sanitary Unit No 2 in Tomsk. From the total group, 28 patients (8 men and 20 women aged from 22 to 84 years) were selected for assessment of vestibular function; the average age was 63.87 ± 11.52 years and 57.2 ± 18.5 years for men and women respectively. They had chronic and episodic vestibular dysfunction unrelated to acute or progressive neurological disease and inflammatory pathology of the inner ear.Results. 27 patients (96.4%) complained of dizziness. Systemic dizziness, characterized by a feeling of objects rotating around the subject, was detected in 29.63% of patients; non-systemic dizziness, including a feeling of “failing” – in 81.48%. Both types of complaints appeared in 10.71% of those examined, which made it possible to identify 2 groups of patients: Group A – with chronic vestibular disorders (7 patients) and Group B – with episodic vestibular disorders (21 patients). During the study of the groups of patients, differences were found in the amplitudes of cVEMP latency P13 and the coefficient of vestibular asymmetry between Groups A and B, as well as the absence of a difference in amplitudes in Group A and the presence of a difference in Group B on the right.Conclusion. Despite the fact that patients presented with predominantly one complaint of dizziness, clinical and instrumental tests of vestibular dysfunction showed the presence of damage to both the semicircular canals and otolithic organs; asymmetry of vestibular reflexes and/or bilateral damage to the vestibular organs. The results of the study allow us to consider the cVEMP method as one of the methods for objectively assessing the condition of the otolithic apparatus in patients with impaired vestibular function. In this regard, it is recommended to use this method in routine neurological practice.
Chronic management and recurrent challenges: a case of multifocal spinal hemangiopericytoma over 7 years. Illustrative case
Authors: Moustafa Wahab , Silbermann Jörg , Badary Amr , Maksoud Salah , Khalil Al-Barbarawi Mohammad 
Published: October 2024

BACKGROUND
Spinal hemangiopericytoma (sHPC) is a rare vascular tumor that presents significant challenges in diagnosis and management due to its potential for recurrence and metastasis.

OBSERVATIONS
This report documents the 7-year clinical course of a 68-year-old female diagnosed with multifocal sHPC. The patient initially presented with myelopathy due to a spinal mass, which was managed with resection, followed by several years of stability. Subsequent magnetic resonance imaging (MRI) revealed new growths, necessitating further interventions, including stereotactic radiosurgery. Despite the recurrence and progression of the disease, the strategic use of surgical and radiosurgical interventions demonstrated significant efficacy in managing tumor growth and alleviating symptoms.

LESSONS
This case emphasizes the critical importance of continual surveillance and a multidisciplinary approach in the treatment of sHPC. Continuous monitoring through regular MRI is essential for early detection of recurrences. Adaptable treatment strategies, including resection and radiosurgery, are necessary to manage the complex dynamics of tumor behavior. This report also highlights the need for patient-centered care and flexible, individualized treatment plans to ensure optimal patient outcomes in the face of recurrent and multifocal disease manifestations.
https://thejns.org/doi/10.3171/CASE24368
Angiographically occult spinal dural arteriovenous fistula diagnosed by exploratory surgery with intraoperative ultrasound: illustrative case
Authors: Jiang Kelly , Weber-Levine Carly , Kerensky Max J , Daniel Davidar A , Manbachi Amir , Pardo Carlos A , Gailloud Philippe , Theodore Nicholas , Jackson Christopher M , Lubelski Daniel , Sotirchos Elias S 
Published: October 2024

BACKGROUND
A 78-year-old male presented with progressive myelopathic symptoms. The clinical course and imaging findings raised a high suspicion for venous hypertensive myelopathy due to a spinal dural arteriovenous fistula (SDAVF).

OBSERVATIONS
Magnetic resonance angiography and four complete spinal angiograms did not reveal the presence of an SDAVF. Despite multiple negative angiograms, intraoperative ultrasound revealed abnormal cord edema and arterialized pulsatile vessels, confirming the presence of an SDAVF. The fistula was found and cauterized, which resulted in a decrease in the caliber of the dilated veins and an observed reduction of spinal cord stiffness posttreatment. The patient exhibited gradual improvement in neurological function. Retrospective analysis of the multiple complete spinal angiograms failed to reveal an anomaly at the treated level or any other level.

LESSONS
This case underscores the diagnostic utility of intraoperative Doppler ultrasound and the importance of maintaining a high index of suspicion for SDAVF in cases with consistent clinical characteristics and a lack of alternative diagnoses, even with negative spinal angiography.
https://thejns.org/doi/10.3171/CASE24438
Using kanban board for forming social time management skills of future IT specialists
Authors: Buzhinskaya N. V. , Grebneva D. M. , Vaseva E. S. 
Published: October 2024

For the professional development of students studying in information technology areas, it is important to develop social time management skills, i.e. skills in organizing well-coordinated teamwork and optimal distribution of responsibilities between team members with minimal time to achieve a common goal. The article aims to substantiate and elaborate methodological recommendations for developing social time management skills using kanban technology in organizing team activities of future IT specialists. Criteria for assessing the development of social time management skills are proposed. The article points out the necessity of including kanban project management technology not only as training content but also as a way to optimize time resources when performing team training projects.The article describes an experiment on teamwork organization of Nizhny Tagil State Socio-Pedagogical Institute (branch) of Russian State Vocational Pedagogical University students. At the initial stage, the determination of the level of formation of social time management skills among 2nd year students in the process of completing a project assignment on software product development was carried out within the discipline “High-level methods of informatics and programming” without the use of time management technologies. The results of this stage showed the need to develop time management skills of future IT specialists in the process of teamwork. Recommendations for organizing student teamwork when using project time management technologies using a kanban board were formulated, which will allow students to develop social time management skills.The next stage of the experiment was the organization of students’ teamwork using flexible project management methodology (kanban technology): taking into account the proposed recommendations in the experimental group, without the use of time management technologies in the control group. The results of the pedagogical experiment showed the expediency of following the proposed methodological recommendations.
Using ChatGPT in planning English language classes
Authors: Stognieva O. N. 
Published: October 2024

The digital transformation is a global trend in modernizing educational systems. Implementing digital technologies in Russian educational institutions has been legally established and has become an everyday practice for teachers and students. The transition to new forms of learning, including interaction with artificial intelligence (AI) in combination with other technological solutions, contributes to solving applied problems, such as optimizing teacher’s working time. This article explores the possibilities of using AI (in particular, ChatGPT) as a tool for English lesson planning and instructional design.The article provides an overview of the capabilities, basic principles of interaction, and prospects for using ChatGPT in the educational process. The main part of the article consists of examples of ChatGPT responses to requests from a user — an English language teacher. As a result of interaction with ChatGPT, we were able to create a lesson plan as well as exercises for the development of lexical skills, for monitoring text understanding, for developing speaking skills and listening skills. The article demonstrates that the use of ChatGPT in English language lesson planning opens new perspectives for effective individualized learning and expands the possibilities for creating attractive and relevant educational content to meet diverse needs of students.
Faktor-Faktor yang Berhubungan dengan Kepemilikan Aplikasi Mobile JKN pada Peserta BPJS Kesehatan di Wilayah Kerja UPT Puskesmas Rawat Inap Ujan Mas
Authors: Angraini Wulan , Pratama Yesa Putri , Yanuarti Riska , Kosvianti Emi , Febriawati Henni 
Published: October 2024

ABSTRACT National health insurance provides individuals with health benefits and protection to meet their basic health needs. Health insurance is provided by the government through the Social Security Administering Agency (BPJS), consisting of BPJS Employment and BPJS Health. In order to increase the efficiency of providing health services, BPJS Health introduced the JKN application. This application represents the latest technological advances aimed at increasing individual convenience in accessing services and information at high costs. The aim of the research is to test or validate research hypotheses that answer research problems, while this particular research methodology can be classified as observational research, where researchers make their own observations of variables without any treatment. The research methodology used was a cross-sectional quantitative design with a chi-square test sample of 106 people. Research findings show that there is a significant correlation between knowledge (P Value=0.000), however, there is no significant correlation between gender (P Value=0.568) and ownership of the JKN mobile application. So it can be concluded that knowledge has a relationship, while gender has no relationship with ownership of the JKN mobile application on BPJS Health participants in the UPT Ujan Mas Inpatient Health Center working are. Keywords: BPJS, Health Services, Mobile JKN ABSTRAK Asuransi kesehatan nasional memberi individu manfaat maupun perlindungan kesehatan untuk terpenuhinya kebutuhan kesehatan mendasar mereka. Jaminan kesehatan diselenggarakan oleh pemerintah melalui Badan Penyelenggara Jaminan Sosial (BPJS) terdiri dari BPJS Ketenagakerjaan maupun BPJS Kesehatan. Guna meningkatkan efisiensi penyelenggaraan pelayanan kesehatan, BPJS Kesehatan memperkenalkan aplikasi JKN. Aplikasi ini mewakili kemajuan teknologi terkini yang bertujuan untuk meningkatkan kenyamanan individu dalam mengakses layanan dan informasi dengan biaya mahal. Tujuan penelitian ialah menguji maupun memvalidasi hipotesis penelitian yang menjawab permasalahan penelitian, sedangkan metodologi penelitian khusus ini dapat digolongkan sebagai penelitian observasional, dimana peneliti melakukan observasi sendiri terhadap variabel tanpa adanya perlakuan apapun. Metodologi penelitian yang digunakan adalah desain kuantitatif cross-sectional dengan sampel uji chi-square sebanyak 106 orang. Temuan penelitian menunjukkan adanya hasil korelasi yang signifikan antara pengetahuan (P Value=0,000) namun, tidak terdapat korelasi yang signifikan antara jenis kelamin (P Value=0,568) dengan kepemilikan aplikasi mobile JKN. Maka dapat disimpulkan bahwa pengetahuan memiliki hubungan, sedangkan jenis kelamin tidak memiliki hubungan dengan kepemilikan aplikasi mobile JKN pada peseta BPJS Kesehatan di wilayah kerja UPT Puskesmas Rawat Inap Ujan Mas. Kata Kunci: BPJS, Layanan Kesehatan, Mobile JKN
The The Specialties of Sundanese Ngujuban Culture in the Community of Maja District
Authors: Andriyani Nuri 
Published: October 2024

Tradisi Budaya Sunda Ngujuban merupakan kegiatan mengarwahkan atau mendatangkan para leluhur. Di dalamnya terdapat penyuguhan berupa sesaji makanan, minuman, jajanan pasar, kembang, rokok, dan pembacaan doa-doa. Bertujuan untuk menghormati dan mengingat para leluhur, serta mensyaratkan keselamatan dan kesejahteraan bagi mereka di alam baka. Budaya ini mengandung moral yang dapat diterapkan di kehidupan sehari-hari. Metode penelitian ini menggunakan metode kualitatif dengan diperkuat oleh deskriptif yang mewawancarai beberapa narasumber berasal dari Kecamatan Maja. Hasil penelitian ini menunjukkan bahwa Keistimewaan Budaya Sunda Ngujuban terdapat pada pelaksanaannya yaitu satu hari sebelum hari raya dan hajat, dimana para karuhun atau leluhur datang mengunjungi tempat keluarganya masing-masing. Terdapat pembelajaran yang bisa diterapkan berupa (1) Nilai Pendidikan; (2) Nilai Religius; (3) Nilai Sosial; (4) Nilai Spiritual; dan (5) Nilai Kultural. Dengan adanya pembahasan mengenai Budaya Sunda Ngujuban diharapkan masyarakat Indonesia khususnya suku Sunda yang belum mengetahui budaya ini bisa menjadi tahu dan menjadikan bahan pembelajaran ilmu mengenai keberagaman yang berada di masyarakat Sunda serta diketahui secara luas juga bermanfaat bagi masyarakat yang lainnya.
Frequency, Causes and Medico-Legal Aspects of Grievous Injury to the Eye after Physical Assault
Authors: Shahid Erum , Fasih Uzma 
Published: October 2024

Aims: A medicolegal report is prepared by the medicolegal officer in conjunction with an ophthalmologist in cases of physical assault claiming vision loss. The objective was to report the frequency and cause of grievous injury to the eye after a physical assault.
Methods: This was a descriptive cross-sectional study, conducted in the Department of Ophthalmology of a tertiary care hospital in Pakistan from October 2019 to August 2022. A total of 378 medicolegal cases were reported in the ophthalmology outpatient. Among them, 285 patients of physical assault were included with consecutive sampling technique.
Results: The mean age of the patients was 33.93±12.96 years. The mean reporting time to an ophthalmologist was 4.1±8.2 days. Simple and grievous injuries were found in 278 (97.5%) and 7 (2.4%) cases, respectively. Among the grievous injuries, 4 (57.2%) were close globe injuries and 3 (42.8%) were open globe injuries. Thirteen (4.5%) were malingers. Domestic violence was observed in 82 (28.8%) study subjects.
Conclusion: The frequency of grievous injury to the eye is very low (2.4%) in patients with physical assault. The patients of assault-related grievous injury were mostly males, young age, low level of education, and doing manual jobs. Vitrolage with corneal melting, and firearm injury caused the grievous injury in open globe patterns. Vitreous hemorrhage, retinal detachment, macular hole, and secondary glaucoma were seen among close globe patterns.
J Bangladesh Coll Phys Surg 2024; 42: 336-341
Evaluation of Split Hand Syndrome in Early Diagnosis of Amyotrophic Lateral Sclerosis by Nerve Conduction Study as a Diagnostic Tool
Authors: Wazib Amit , Rahman Shaila , Ahmed Md Rayhan 
Published: October 2024

Background: Amyotrophic lateral sclerosis (ALS), a degenerative disease of the motor neurons that can present diversly. Needle electromyography (EMG) is the gold standard investigation for the diagnosis of ALS. Split hand syndrome (SHS) demonstrated by nerve conduction study (NCS); a noninvasive tool could be useful in diagnosing ALS. This study aimed to assess SHS by NCS in ALS.
Methods: This diagnostic accuracy case-control study included 37 cases of ALS and 37 age and gender-matched controls. Compound muscle action potential (CMAP) and distal motor latency (DML) of median and ulnar nerves and the ratio of median and ulnar CMAP and DML were compared between study groups. The diagnostic validity testing of electrophysiological SHS was also done.
Results: The mean age of the ALS and control groups were similar, 39.8±2.7 and 39.3±2.6 years, respectively. Sixteen (43.2%) ALS patients were in 30-59 years age group. Male-female ratio was 5.2. In the ALS group, median-ulnar CMAP ratio was lower and median-ulnar DML ratio was prolonged than the control. The diagnostic efficacy of median-ulnar CMAP ratio and DML ratio were calculated. A median-ulnar CMAP ratio cut-off value ≤1 showed 70% sensitivity, 97% specificity, 96% positive predictive value and 77% negative predictive value. A median-ulnar DML ratio cut-off value ≥1.5 showed 48% sensitivity, 89% specificity, 82% positive predictive value and 65% negative predictive value.
Conclusion: NCS demonstrating SHS can be an important tool in the early diagnosis of ALS.
J Bangladesh Coll Phys Surg 2024; 42: 350-354
Upaya meningkatkan hasil belajar bulutangkis materi pukulan forehand lob melalui metode teaching games for understanding pada siswa kelas V C di sekolah dasar negeri pulogebang 01 jakarta timur
Authors: Supriadi Wahyu , Abidin Dindin 
Published: October 2024

Tujuan penelitian ini untuk mengetahui apakah pendekatan teaching games for understanding dapat meningkatkan hasil belajar pukulan forehand lob permainan bulutangkis pada siswa kelas V.C Sekolah Dasar Negeri Pulogebang 01 Jakarta Timur. Adapun metode yang digunakan dalam penelitian ini adalah penelitian tindakan kelas (classroom action research), sedangkan subyek dalam penelitian ini adalah, siswa kelas kelas V.C Sekolah Dasar Negeri Pulogebang 01 Jakarta Timur yang berjumlah. 32 orang.
Hasil penelitian telihat peningkatan hasil belajar pukulan forehand lob permainan bulutangkis, obervasi awal menunjukkan hanya 15 orang (46.88%) siswa yang mencapai nilai KKM. Pada siklus 1 terdapat peningkatan yang cukup signifikan hasil menunjukkan 21 orang siswa (65.63%) siswa yang mencapai nilai KKM. Sedangkan pada siklus 2 didapat hasil 26 orang siswa (81.25%) siswa yang mencapai nilai KKM Pada siklus 2 hasil yang dicapai telah sesuai dengan apa yang di targetnya yaitu 75% siswa telah mencapai nilai KKM, dalam hal ini 81.25% siswa telah mencapai nilai KKM, sehingga tidak dilanjutkan pada siklus III.
Enhancing Human Capital Management through DevOps Practices
Authors: Suharminto Bayu Dwi , Wijaya Alek , Sutabri Tata , Syazili Ahmad 
Published: October 2024

In the current era of digital revolution, one of the main factors influencing an organization's performance is human resources. This is because HR is an important asset that determines the productivity and efficiency of organizational performance. This study's goal is to create and construct an integrated human resources application using the DevOps (Development and Operations) approach. The DevOps method is a collabo rative approach that combines the process of software development and operations in a sustainable, fast, and integrated manner. The human resources application developed in this research includes various important functions, including HR management, job grade promotion planning, employment contract termination notification, and promotion notification. This research also provides solutions to the problems experienced by the Palembang Region Office of PT Bank Rakyat Indonesia in human resource management. By using the DevOps method as a method of designing human capital applications, it is expected to increase employee efficiency and productivity through integrated and effective human resource management. The DevOps approach also allows organizations to respond quickly to changing needs and provide sustainable added value to the organization.
Procollagen-lysine 2-oxoglutarate 5-dioxygenases are responsible for 5R-hydroxylysine modification of therapeutic T-cell bispecific monoclonal antibodies produced by Chinese hamster ovary cells
Authors: Bauer Niels , Boettger Marco , Papadaki Styliani , Leitner Tanja , Klostermann Stefan , Kettenberger Hubert , Georges Guy , Larraillet Vincent , Gluhacevic von Kruechten Dino , Hillringhaus Lars , Vogt Annette , Ausländer Simon , Popp Oliver 
Published: October 2024

We present a detailed mass spectrometric analysis of three 2 + 1 T-cell bispecific monoclonal antibodies (TCB mAbs), where an unexpected +15.9950 Da mass shift in tryptic peptides was observed. This modification was attributed to the occurrence of 5R-hydroxylysine (Hyl) using a hybrid LC–MS/MS molecular characterization and CRISPR/Cas9 gene deletion approach. The modification was found at various sites within TCB mAbs, with a conspicuous hot spot motif mirroring a prior observation where Hyl was mapped to the CH1–VH Fab domain interface of IgGs. In contrast to the preceding report, our structural modeling analysis on TCB mAbs unveiled substantial differences in the orientation and flexibility of motifs in immediate proximity and across the artificial CH1–VL cross Fab interface and upstream elbow segment. Utilizing a hybrid database search, RNAseq, and a CRISPR/Cas9 knockout methodology in Chinese hamster ovary (CHO) production cell lines, procollagen-lysine, 2-oxoglutarate 5-dioxygenases (PLODs) were conclusively identified as the catalyzing enzymes accountable for the 5R-Hyl modification in TCB mAbs. To quantitatively inhibit Hyl formation in TCB mAbs, the activity of all three Chinese hamster PLOD isoenzymes needs to be depleted via CRISPR/Cas9 gene knockout. Moreover, our investigation identified cell culture iron availability, process duration, and clonal variability in CHO cells as elements influencing the levels of Hyl formation in TCB mAbs. This research offers a solution for circumventing Hyl formation in therapeutic complex mAb formats, such as TCB mAbs, produced in CHO cell culture processes, thereby addressing potential technical and biological challenges associated with unintended Hyl modification.