bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of implant stability and bone density derived from computerized tomography images
Authors: Merheb Joe , Vercruyssen Marjolein , Coucke Wim , Quirynen Marc 
Published: December 2017

AbstractBackground and PurposeImplant stability is one of the most important factors influencing osseointegration. Using stereolithographical guides for maximizing precision, this study aimed at investigating the relationship between implant stability and bone density derived from computerized tomography analysis.Materials and MethodsOne hundred ninety‐five implants were placed in 48 patients using digitally designed stereolithographical surgical guides. Ninety‐five implants were placed using a mucosa supported guide and 100 implants were placed using a bone supported guide. Implant stability was measured by means of resonance frequency analysis (RFA) and damping capacity assessment (Periotest, PTV). Bone density (Hounsfield units) was measured at different regions of interest (ROI) and cortex thickness was measured around each implant.ResultsImplant stability correlated significantly with the different ROI. The best correlation for RFA was obtained for the spongious bone ROI (r = .64) and PTV best correlated with the coronal cortex density (r = −.41). Shorter implants (9 mm) had a significantly lower primary stability than longer implants (11, 13, 15 mm). Primary stability was also significantly higher in 4 mm diameter implants than in 3.5 mm diameter implants. A formula for the prediction of primary stability based on the different variables investigated was developed.ConclusionsBone density and cortex thickness have a significant influence on implant primary stability. Longer and wider implants reached higher primary stability than shorter and narrower implants. These correlations lose their significance after osseointegration has taken place. Implant stability can be predicted based on an preoperative analysis of bone characteristics.
FAM20C could be targeted by TET1 to promote odontoblastic differentiation potential of human dental pulp cells
Authors: Li Qimeng , Yi Baicheng , Feng Zhihui , Meng Runsha , Tian Cheng , Xu Qiong 
Published: December 2017

AbstractObjectivesTen‐eleven translocation 1 (TET1) is a DNA methylcytosine (mC) dioxygenase discovered recently that can convert 5‐mC into 5‐hydroxymethylcytosine (5hmC). We previously reported that TET1 promotes odontoblastic differentiation of human dental pulp cells (hDPCs). The gene encoding the family with sequence similarity 20, member C (FAM20C) protein, is a potential TET1 target and showed demethylation during odontoblastic differentiation of hDPCs in our previous study. This study aimed to explore whether TET1‐mediated hydroxymethylation could activate the FAM20C gene, thereby regulating hDPC differentiation.Materials and methodsThe expression pattern of FAM20C and its potential changes during odontoblastic induction of hDPCs were assessed by Western blotting. Lentivirus‐mediated transduction with short hairpin RNA (shRNA) was used to knock down FAM20C and TET1 expression in hDPCs. The mineralization potential of hDPCs was evaluated with an ALPase activity assay and by observing the mineralized matrix deposition and the expression of odontoblast‐related markers DSPP and DMP1. Recombinant human FAM20C protein (rhFAM20C) was reintroduced into shTET1 cells in a rescue experiment. The dynamic hydroxymethylation status of the FAM20C gene promoter was examined using hydroxymethylated DNA immunoprecipitation (IP)‐PCR. Chromatin IP‐PCR and agarose gel electrophoresis were utilized to validate the recruitment of TET1 to its target loci in the FAM20C promoter.ResultsFAM20C protein level was upregulated after the odontoblastic induction of hDPCs. shRNA‐mediated FAM20C suppression reduced the expression of DSPP and DMP1 after odontoblastic induction for 7 and 14 days. ALPase activity was reduced on day 7, and the formation of mineralized nodules was attenuated on day 14 after odontoblastic induction in FAM20C‐inhibited hDPCs. Genomic 5hmC levels significantly decreased, and total 5mC levels increased in TET1‐deficient hDPCs. In addition, a significant reduction in FAM20C also emerged. The rhFAM20C treatment of shTET1 cells attenuated the mineralization abnormalities caused by TET1 depletion. TET1 depletion prompted a decline in 5hmC levels in several regions on the FAM20C promoter. Enhanced TET1 recruitment was detected at the corresponding loci in the FAM20C promoter during odontoblastic induction.ConclusionTET1 knockdown suppressed odontoblastic differentiation by restraining its direct binding to FAM20C promoter, and hence inhibiting FAM20C hydroxymethylation and subsequent transcription. These results suggest that TET1 potentially promotes the cytodifferentiation potential of hDPCs through its DNA demethylation machinery and upregulation of FAM20C protein expression.
The Financialization of Finance? Demonetization and the Dubious Push to Cashlessness in India
Authors: Chandrasekhar C.P. , Ghosh Jayati 
Published: December 2017

ABSTRACTThis Debate contribution describes the promotion of digital rather than cash payments as a form of the financialization of finance, in its role as a payments system, with reference to recent Indian experience. The arguments in favour of reducing cash usage must be seen relative to the costs of digital payments, for both society and individuals. The drastic demonetization episode in India, which removed 86 per cent of the value of notes in circulation at one stroke in November 2016, was partly justified in terms of forcing a shift to cashless transactions. However, such a shift requires that adequate infrastructure be in place in terms of banking and connectivity, both of which are currently lacking in India. The article also identifies other concerns with digital transactions including higher costs and the possibilities of loss of privacy, fraud, identity theft and surveillance. The obsession with digital transactions as a marker of social and material progress is misplaced; it may become yet another means by which finance extracts rentier incomes out of relatively poor populations.
Improving Women's Substantive Representation in Community Government: Evidence from Chinese Villages
Authors: Sargeson Sally , Jacka Tamara 
Published: December 2017

ABSTRACTThe premise that increasing the number of women in government improves the representation of women's views and needs continues to motivate efforts in developing countries to raise the proportion of women in political office by means of gender‐differentiating ideologies and gender‐affirmative actions. This article raises the concern that a focus on boosting women's descriptive representation distracts attention from other interventions that potentially might be more effective in improving women's substantive representation. The article theoretically compares factors that have the potential to affect the two dimensions of representation, and empirically investigates which of these are conducive to women's substantive representation in community government. Based on case studies of villages in one rich and one poor province of China, the authors conclude that higher democratic quality, combined with stronger financial resources and institutions, produce greater improvements in women's substantive representation than gender ideologies and affirmative actions. This finding challenges the strategies used by development agencies, and identifies factors with the potential to improve women's representation in government, even in one‐party states.
Educational outcomes for children with cerebral palsy: a linked data cohort study
Authors: Gillies Malcolm B , Bowen Jennifer R , Patterson Jillian A , Roberts Christine L , Torvaldsen Siranda 
Published: December 2017

AimTo identify a cohort of children with cerebral palsy (CP) from hospital data; determine the proportion that participated in standardized educational testing and attained a score within the normal range; and describe the relationship between test results and motor symptoms.MethodThis population‐based retrospective cohort study used data from New South Wales, Australia. We linked hospital data for children younger than 16 years of age admitted between 1st July 2000 and 31st March 2014 to education data from 2009 to 2014. Hospital diagnosis codes were used to identify a cohort of children with CP (n=3944) and describe their motor symptoms. Educational outcomes in the CP cohort were compared with those among children without CP.ResultsOf those with educational data (n=1770), 46% were exempt from reading assessment because of intellectual or functional disability, 7% were absent or withdrawn from testing and 47% participated in testing. About 30% of all children with educational data had test scores in the normal range. The proportion was greatest among those with hemiplegia (>40%) and lowest among those with tetraplegia (<10%).InterpretationOne‐third of children with CP participated in standardized testing and achieved a result in the normal range. The proportions were lower in children with more severe motor symptoms.What this paper adds

From 2009 to 2014, most Australian children with cerebral palsy (CP) attended a mainstream school.

The rate of disability‐related exemption from standardized educational testing was almost 50%.

Thirty per cent of children with CP achieved educational scores in the normal range.
Life satisfaction is a protective factor against the onset of Type 2 diabetes in men but not in women: findings from the MONICA/KORA cohort study
Authors: Piciu A. M. , Johar H. , Lukaschek K. , Thorand B. , Ladwig K. H. 
Published: December 2017

AbstractAimsTo investigate the association of high life satisfaction with incident Type 2 diabetes separately in men and women.MethodsA longitudinal analysis was conducted among the 7107 participants (3664 men, 51.5%; 3443 women, 48.5%) aged 25–74 years (mean ± sd age 47.8 ±13.7 years) of two population‐based MONICA/KORA surveys conducted in 1989–1995 and followed up until 2009. Life satisfaction was assessed using a one‐item instrument with a six‐order response level, which was dichotomized into high vs medium or low. Sex‐specific hazard ratios were estimated using Cox proportional hazards models.ResultsCrude incidence rates for Type 2 diabetes per 10 000 person‐years were lower in participants with high than in those with medium or low life satisfaction (men: 57 vs 73; women: 37 vs 48). In men with high life satisfaction, there was a 27% risk reduction in incident Type 2 diabetes (hazard ratio 0.73, 95% CI 0.56–0.94; P=0.02) in a model adjusted for sociodemographic, behavioural and clinical risk factors. The association lost statistical significance after further adjusting for depressed mood (hazard ratio 0.79, 95% CI 0.61–1.03). Life satisfaction was not significantly associated with incident Type 2 diabetes in women.ConclusionLife satisfaction may be a valuable asset in assessing risk of Type 2 diabetes, especially in men, and in the development of more effective prevention strategies to deter onset of diabetes. More research is needed to investigate the underlying potential causal pathways that may link life satisfaction to the development of Type 2 diabetes.
Sulfonylurea vs insulin therapy in individuals with sulfonylurea‐sensitive permanent neonatal diabetes mellitus, attributable to a KCNJ11 mutation, and poor glycaemic control
Authors: Stanik J. , Dankovcikova A. , Barak L. , Skopkova M. , Palko M. , Divinec J. , Klimes I. , Gasperikova D. 
Published: December 2017

AbstractBackgroundTherapy with sulfonylurea is preferable to insulin in the majority of individuals with KCNJ11 mutations, but not all of these people achieve target levels of HbA1c in long‐term follow‐up. We aimed to compare sulfonylurea therapy with insulin treatment in two sulfonylurea‐sensitive individuals with a KCNJ11 mutation who had poorly controlled permanent neonatal diabetes mellitus.Case reportWe report on two individuals with a KCNJ11 mutation (p.R201H) who are currently aged 35 (SVK1) and 21 years (SVK2). These individuals were switched from insulin to sulfonylurea in 2005. Data from the first 4 (SVK2) and 8 years (SVK1) of the follow‐up showed improved diabetes control and increased quality of life for both individuals. During the following years, however, both individuals failed to retain good diabetes control (HbA1c ≤ 53 mmol/mol; 7.0%). We therefore changed the therapy to a combination of insulin and sulfonylurea in both individuals, or to insulin monotherapy in SVK1, and compared the effects on HbA1c with those of sulfonylurea monotherapy. HbA1c levels in both individuals worsened after adding insulin to sulfonylurea [67 mmol/mol (8.3%) vs 77 mmol/mol (9.2%) in SVK1 and 106 mmol/mol (11.8%) vs 110±19 mmol/mol (12.2±1.7%) in SVK2], and after switching to only insulin therapy in SVK1 [57 mmol/mol (7.4%) vs 62 mmol/mol (7.8%)] when compared with sulfonylurea monotherapy.DiscussionOur data show that sulfonylurea monotherapy might be preferable to insulin in people with permanent neonatal diabetes mellitus sensitive to sulfonylurea even when HbA1c is above target.
Subjective quality of life in recent onset of psychosis patients and its association with sociodemographic variables, psychotic symptoms and clinical personality traits
Authors: Sevilla‐Llewellyn‐Jones Julia , Cano‐Domínguez Pablo , de‐Luis‐Matilla Antonia , Espina‐Eizaguirre Alberto , Moreno‐Kustner Berta , Ochoa Susana 
Published: December 2017

AimThere is lack of research on the study of clinical personality traits in recent onset of psychosis (ROP) patients. The aims of this research were to study the relations among psychosocial, personality and clinical characteristics in ROP patients and also the effect that significant variables had on the different domains of Quality of Life (QoL).MethodsData for these analyses were obtained from 81 ROP patients. The Millon Clinical Multiaxial Inventory, the Positive and Negative Syndrome Scale and the World Health Organization Quality of Life Brief Scale were used to assess personality, symptoms and QoL.ResultsCorrelations between the negative symptoms and the physical, psychological and social domains of QoL, and the disorganized symptoms and physical domain, were found. Furthermore, the physical, psychological and social relationship domains of QoL were lower in patients with schizoid traits and the psychological domain was lower in patients with depressive traits. In contrast, the psychological and social domains were higher in patients with histrionic traits, while the physical domain was higher for patients with narcissistic traits. Multiple linear regressions demonstrated that negative symptoms and narcissistic and depressive traits explained 16.9% of the physical domain. Narcissistic and depressive traits explained 15% of the psychological domain. Finally, the negative symptoms and histrionic traits explained 13.7% of the social domain.ConclusionsQoL seems to be better explained by negative psychotic symptoms and some clinical personality traits. Our results support the importance of integrated intervention approaches that consider personality.
Reading from the middle: Heidegger and the narrative self
Authors: Roth Ben 
Published: December 2017

AbstractHeidegger's Being and Time is an underappreciated venue for pursuing work on the role narrative plays in self‐understanding and self‐constitution, and existing work misses Heidegger's most interesting contribution. Implicit in his account of Dasein (an individual human person) is a notion of the narrative self more compelling than those now on offer. Bringing together an adaptive interpretation of Heidegger's notion of “thrown projection”, Wolfgang Iser's account of “the wandering viewpoint”, and more recent Anglo‐American work on the narrative self, I argue that we read our ongoing existences in the same way that, mid‐story, we read a narrative. Reading is a better master metaphor than authorship, narration, plot, or character to guide investigations of narrative's relation to the self. It is not merely a metaphor, however, as the hermeneutic structures involved in interpreting existence and a narrative from the middle are the same.
Containment and ‘rational health’: Moran and psychoanalysis
Authors: Harcourt Edward 
Published: December 2017

AbstractThe paper focuses on Richard Moran's account (inAuthority and Estrangement) of the distinction between attitudes that meet, and alternatively fail to meet, his transparency criterion for what he calls rational health, and compare this with the psychoanalytic distinction between contained and uncontained states of mind. On the face of it, Moran's distinction appears to be a useful theoretical deepening of the psychoanalytic distinction. On closer examination, however, it appears that (a) rational health is a more demanding standard than containment, so the rationally unhealthy contains much that is mentally (quite) healthy; and (b) more seriously, some states that meet the “transparency” condition are manifestly mentally unhealthy. So transparency needs to be supplemented by an independently understood notion of containment to approach a realistic norm of mental health/ill health.
A novel lateral flow immunoassay for the rapid detection of anti‐Dsg3 IgG serum autoantibodies in pemphigus vulgaris
Authors: Schmidt Thomas , Mauracher Susanne , Bender Lena , Greene Brandon , Kurzhals Jonas , Eming Rüdiger , Dostatni Ralf , Hertl Michael 
Published: December 2017

AbstractPemphigus vulgaris (PV) is a severe autoimmune blistering disease of the skin and mucous membranes. As autoantibodies play an essential role in the disease pathogenesis, the serological detection of anti‐desmoglein 3 IgG represents a central tool in the diagnosis of the disease. In this study, we show the validation of a novel lateral flow immunoassay (LFIA) which rapidly detects anti‐desmoglein 3 (Dsg3) IgG in human serum. In contrast to other diagnostic procedures, the assay is compact and simple to perform and delivers a fast ”yes” or “no” answer within 10 minutes without additional hardware requirements for test evaluation. For validation, a blinded collection of 200 sera including 100 sera from 14 PV patients, 75 sera from 24 bullous pemphigoid patients and 25 sera from 6 patients with pemphigus foliaceus collected at different time points during disease was used. Presence or non‐presence of anti‐Dsg3 IgG within sera was confirmed using a commercially available Dsg3‐ELISA. For qualitative evaluation, Dsg3‐LFIA test results were assessed by two independent groups of human observers. Furthermore, quantitative evaluation using POCScan reader was applied. The Dsg3‐LFIA demonstrated reliable test results with a sensitivity and specificity of 78.1% and 97.1%, respectively. Test results from POCScan and human observers showed a substantial agreement. The Dsg3‐LFIA represents a new diagnostic tool for the immediate and reliable detection of anti‐desmoglein 3 serum IgG autoantibodies that does not require additional hardware. Further prospective trials are warranted to validate the Dsg3 LFIA in pemphigus.
Functional role of the core gap in the middle part of tropomyosin
Authors: Matyushenko Alexander M. , Shchepkin Daniil V. , Kopylova Galina V. , Bershitsky Sergey Y. , Koubassova Natalia A. , Tsaturyan Andrey K. , Levitsky Dmitrii I. 
Published: December 2017

Tropomyosin (Tpm) is an α‐helical coiled‐coil actin‐binding protein playing an essential role in the regulation of muscle contraction. The middle part of the Tpm molecule has some specific features, such as the presence of noncanonical residues as well as a substantial gap at the interhelical interface, which are believed to destabilize a coiled‐coil and impart structural flexibility to this part of the molecule. To study how the gap affects structural and functional properties of α‐striated Tpm (the Tpm1.1 isoform that is expressed in cardiac and skeletal muscles) we replaced large conserved apolar core residues located at both sides of the gap with smaller ones by mutations M127A/I130A and M141A/Q144A. We found that in contrast with the stabilizing substitutions D137L and G126R studied earlier, these substitutions have no appreciable influence on thermal unfolding and domain structure of the Tpm molecule. They also do not affect actin‐binding properties of Tpm. However, they strongly increase sliding velocity of regulated actin filaments in an in vitro motility assay and cause an oversensitivity of the velocity to Ca2+ similar to the stabilizing substitutions D137L and G126R. Molecular dynamics shows that the substitutions studied here increase bending stiffness of the coiled‐coil structure of Tpm, like that of G126R/D137L, probably due to closure of the interhelical gap in the area of the substitutions. Our results clearly indicate that the conserved middle part of Tpm is important for the fine tuning of the Ca2+ regulation of actin–myosin interaction in muscle.
Diel habitat selection of largemouth bass following woody structure installation in Table Rock Lake, Missouri
Authors: Harris J. M. , Paukert C. P. , Bush S. C. , Allen M. J. , Siepker M. J. 
Published: December 2017

AbstractLargemouth bass Micropterus salmoides (Lacepède) use of installed habitat structure was evaluated in a large Midwestern USA reservoir to determine whether or not these structures were used in similar proportion to natural habitats. Seventy largemouth bass (>380 mm total length) were surgically implanted with radio transmitters and a subset was relocated monthly during day and night for one year. The top habitat selection models (based on Akaike's information criterion) suggest largemouth bass select 2–4 m depths during night and 4–7 m during day, whereas littoral structure selection was similar across diel periods. Largemouth bass selected boat docks at twice the rate of other structures. Installed woody structure was selected at similar rates to naturally occurring complex woody structure, whereas both were selected at a higher rate than simple woody structure. The results suggest the addition of woody structure may concentrate largemouth bass and mitigate the loss of woody habitat in a large reservoir.
Identification of prognostic factors for activities of daily living in elderly patients after hospitalization for acute infectious disease in Japan: A 6‐month follow‐up study
Authors: Goto Ryohei , Watanabe Hiroki , Haruta Junji , Tsutsumi Madoka , Yokoya Shoji , Maeno Tetsuhiro 
Published: December 2017

AimWe investigated factors that predict the prognosis of activities of daily living (ADL) in elderly patients who had undergone rehabilitation during hospitalization for acute infectious disease.MethodsThe present prospective cohort study included 131 patients who were hospitalized due to acute infectious disease and who had undergone rehabilitation during hospitalization. Patient characteristics collected from medical records included age, sex and comorbidity score. The level of ADL 2 weeks before admission was assessed by interview at the start of rehabilitation. Grip strength testing, Short Physical Performance Battery as an assessment of lower limb function and the Mini‐Mental State Examination as an assessment of cognitive status were carried out at the time of hospital discharge. The level of ADL at 6 months after discharge was assessed by telephone interview. Multivariate logistic regression analysis was used to identify factors that independently predict ADL dependence (defined as being dependent in one or more ADL items at 6 months after discharge).ResultsThe average age of participants was 81.5 years, and 52.7% were women. A total of 22.1% of patients showed dependence in an ADL at 6‐month follow‐up. Factors that predicted an ADL dependence were comorbidity score (OR 4.19, 95% CI 1.19–14.69) and lower limb function (OR 0.51, 95% CI 0.36–0.72) at discharge.ConclusionsThe present findings have implications for the healthcare planning and well‐being of elderly patients during hospitalization and after discharge. Geriatr Gerontol Int 2018; 18: 615–622.