bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of surface and filtration properties of TiO2 coated ultrafiltration polyacrylonitrile membranes
Authors: Kovács I. , Veréb G. , Kertész Sz. , Beszédes S. , Hodúr C. , László Zs. 
Published: December 2017

Abstract
In the present work, the surface and filtration properties of TiO2 coated polyacrylonitrile ultrafiltration membranes were investigated. The membranes were coated using the physical deposition method. The appropriate TiO2 coverage proved to be 0.3 mg/cm2, which formed a hydrophilic cake layer on the membrane surface. The cleanability without chemicals and the retention of the coated membranes was compared to the neat membrane after model oily wastewater filtration. The cleaning sustained of rinsing with distilled water and ultraviolet (UV) irradiation of the fouled membranes. The coated membranes have better antifouling properties; higher flux values during oily water filtration and by the mentioned cleaning process a significantly better flux recovery can be achieved. The amount of the catalyst and the irradiation time are limiting factors to the effectiveness of the cleaning process. The UV irradiation increases the wettability of the fouled membrane surface by degrading the oil layer. The coating, the continuous use, and the cleaning process do not significantly affect the membrane retention expressed in chemical oxygen demand.
Antidiabetics: Structural Diversity of Molecules with a Common Aim
Authors: Popovic-Djordjevic Jelena B. , Jevtic Ivana I. , Stanojkovic Tatjana P. 
Published: December 2017

Background:
Diabetes mellitus type 2 (DMT2) is an endocrine disease of global
proportions which is currently affecting 1 in 12 adults in the world, with still increasing
prevalence. World Health Organization (WHO) declared this worldwide health problem, as an
epidemic disease, to be the only non-infectious disease with such categorization. People with
DMT2 are at increased risk of various complications and have shorter life expectancy. The
main classes of oral antidiabetic drugs accessible today for DMT2 vary in their chemical
composition, modes of action, safety profiles and tolerability.

Methods:
A systematic search of peer-reviewed scientific literature and public databases has
been conducted. We included the most recent relevant research papers and data in respect to
the focus of the present review. The quality of retrieved papers was assessed using standard
tools.

Results:
The review highlights the chemical structural diversity of the molecules that have the
common target-DMT2. So-called traditional antidiabetics as well as the newest and the least
explored drugs include polypeptides and amino acid derivatives (insulin, glucagon-like peptide
1, dipeptidyl peptidase-IV inhibitors, amylin), sulfonylurea derivatives, benzylthiazolidine-
2,4-diones (peroxisome proliferator activated receptor-γ agonists/glitazones),
condensed guanido core (metformin) and sugar-like molecules (α-glucosidase and sodium/
glucose co-transporter 2 inhibitors).

Conclusion:
As diabetes becomes a more common disease, interest in new pharmacological
targets is on the rise.
RDR Application: An Accurate HTHP Rheological Modeling for The Sulphonated Water-Based Drilling Fluid
Authors: Xu Lin , Gao Han , Xu Ming-biao , You Fu-chang , Wang Xiao-liang 
Published: December 2017

Introduction:
An accurate HTHP rheological model of drilling fluids is critical for the safe and economic drilling operation. However, general HTHP rheological modeling methods appear to be very limited in the predictive accuracy.

Materials and Method:
In this work, a particular relative dial readings(RDR) modeling experiment was conducted on a weighted sulphonated water-based drilling fluid within a certain temperature and pressure range(30-150°C, 0.1-100MPa), in combination to dial reading data of six specific shear rates 3, 6, 100, 200, 300, and 600rpm, to develop a highly accurate HTHP rheological model. The RDR modeling procedure was investigated in details, including relative dial reading, Arrhenius relation, polynomial of pressure coefficients, and polynomial of shear rate coefficients. An equation relating RDR to temperature, pressure, and shear rate was determined.

Results:
The predictive deviation was calculated to be lower than 11.7%, and large errors occurred under the conditions of high pressure and low shear rates; all of which meet the requirement of in-field predictive accuracy. These results not only provide an accurate HTHP rheological equation for the weighted sulphonated water-based drilling fluid, but also propose an effective HTHP rheological modeling strategy for drilling fluids.
The Influence of Natural and Synthetic Fibre Reinforcement on Wood-Gypsum Composites
Authors: Carmen Rodríguez-Liñán , María J. Morales-Conde , P. Rubio-De-Hita , F. Pérez-Gálvez , A. Pedreño-Rojas Manuel 
Published: December 2017

Objective:
This paper studies the influence of natural and synthetic fibres on the mechanical behaviour of recycled wood-gypsum composites. These composites of wood waste, such as wood shavings and sawdust, were tested using different proportions of each type of recycled wood. The fibres used, straw as a natural fibre and glass fibre as a synthetic fibre, were analysed in two different proportions.

Method:
The experimental procedure was based on the analysis of the physical properties, density and mechanical properties, flexural strength and compression of the reinforced mixtures. Water absorption by capillarity and the thermal behaviour of the new wood-gypsum materials were also studied.

Results and Conclusion:
The results show that the use of both types of fibres in the mixtures produces lighter composites, and reinforcement by glass fibre represents a significant increase in their flexural strength.
Development of New Eco-Efficient Cement-Based Construction Materials and Recycled Fine Aggregates and EPS from CDW
Authors: Mercader-Moyano Pilar , Requena García-de-la-Cruz Maria Victoria , Yajnes Marta Edith 
Published: December 2017

Background:This research paper presents the results of the characterization and adaptation of the construction product developed by the Experimental Centre of Production of the Faculty of Architecture, Design and Urbanism of the University of Buenos Aires, Argentina (CEP FADU UBA) for Spanish regulations. Additionally, it shows the study of the industrialization of its manufacturing process in Spain. The product consists of a cement-based compound that includes recycled fine ceramic aggregates and EPS from rehabilitation works.Objectives:The aim of this research work is to propose a new eco-efficient construction product adapted to Spanish and European regulations in order to minimize the environmental impact of the construction activity, improve energy efficiency and reduce construction costs. Furthermore, it is presented as a solution to the problem that construction and demolition waste management represents.Method and Results:Samples have been tested to the water absorption and compression resistance tests according to UNE standards. These parameters serve to delimit its use in new sustainable constructive solutions for the design of zero energy consumption buildings (nZEB).Conclusion:Results show that it is possible to obtain certain samples that include recycled ceramic aggregates and EPS which present good response to the mechanical and water absorption tests. In addition, it is obtained that industrializing this product in Spain is complex due to the current waste management system.
Understanding Personalized Training Responses: Can Genetic Assessment Help?
Authors: Pickering Craig , Kiely John 
Published: December 2017

Background:Traditional exercise prescription is based on the assumption that exercise adaptation is predictable and standardised across individuals. However, evidence has emerged in the past two decades demonstrating that large inter-individual variation exists regarding the magnitude and direction of adaption following exercise.Objective:The aim of this paper was to discuss the key factors influencing this personalized response to exercise in a narrative review format.Findings:Genetic variation contributes significantly to the personalized training response, with specific polymorphisms associated with differences in exercise adaptation. These polymorphisms exist in a number of pathways controlling exercise adaptation. Environmental factors such as nutrition, psycho-emotional response, individual history and training programme design also modify the inter-individual adaptation following training. Within the emerging field of epigenetics, DNA methylation, histone modifications and non-coding RNA allow environmental and lifestyle factors to impact genetic expression. These epigenetic mechanisms are themselves modified by genetic and non-genetic factors, illustrating the complex interplay between variables in determining the adaptive response. Given that genetic factors are such a fundamental modulator of the inter-individual response to exercise, genetic testing may provide a useful and affordable addition to those looking to maximise exercise adaption, including elite athletes. However, there are ethical issues regarding the use of genetic tests, and further work is needed to provide evidence based guidelines for their use.Conclusion:There is considerable inter-individual variation in the adaptive response to exercise. Genetic assessments may provide an additional layer of information allowing personalization of training programmes to an individual’s unique biology.
State of Democracy in Sri Lanka: A Preliminary Report
Authors: Uyangoda Jayadeva , Peiris Pradeep 
Published: December 2017

This paper is a preliminary report on citizens understanding and perceptions of democracy in Sri Lanka, as reflected in a survey carried out in 2004-2005. The survey was a part of a South Asian study covering Bangladesh, India, Nepal, Pakistan, and Sri Lanka on the theme "State of Democracy and Human Security in South Asia." The report of the overall study has now been published as State of Democracy in South Asia: A Report (2008).In terms of methodology, the study had four methodological 'pathways'. They are (i) case studies, (ii) dialogues, (iii) qualitative assessments, and (iv) cross-section surveys. The cross section survey carried out in each country was the principal instrument of data collection for the study. It sought to elicit broad trends of people's opinions, attitudes and behaviour in relation to democracy. The other three pathways provided qualitative assessments and dimensions that were not captured in the cross-section survey. The pathway of 'Dialogues' was chosen in order to recognise and retrieve bodies and voices of critical knowledge that are available among different social and political constituencies. Under the component 'Qualitative Assessments', scholars active in social science research were asked to 'assess' the experience of democracy in a non-partisan basis. The qualitative assessments addressed questions formulated around five key themes: (i) the promise of democracy, (ii) design of democracy, (iii) working of democracy, (iv) democracy's outcomes, and (v) democracy's futures.
The Effect of Extended Release Niacin on Markers of Mineral Metabolism in CKD
Authors: Malhotra Rakesh , Katz Ronit , Hoofnagle Andrew , Bostom Andrew , Rifkin Dena E. , Mcbride Ruth , Probstfield Jeffrey , Block Geoffrey , Ix Joachim H. 
Published: December 2017

Background and objectives
Niacin downregulates intestinal sodium-dependent phosphate transporter 2b expression and reduces intestinal phosphate transport. Short-term studies have suggested that niacin lowers serum phosphate concentrations in patients with CKD and ESRD. However, the long-term effects of niacin on serum phosphate and other mineral markers are unknown.

Design, setting, participants, & measurements
The Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health Trial was a randomized, double-blind, placebo-controlled trial testing extended release niacin in persons with prevalent cardiovascular disease. We examined the effect of randomized treatment with niacin (1500 or 2000 mg) or placebo on temporal changes in markers of mineral metabolism in 352 participants with eGFR<60 ml/min per 1.73 m2 over 3 years. Changes in each marker were compared over time between the niacin and placebo arms using linear mixed effects models.

Results
Randomization to niacin led to 0.08 mg/dl lower plasma phosphate concentrations per year of treatment compared with placebo (P<0.01) and 0.25 mg/dl lower mean phosphate 3 years after baseline (3.32 versus 3.57 mg/dl; P=0.03). In contrast, randomization to niacin was not associated with statistically significant changes in plasma intact fibroblast growth factor 23, parathyroid hormone, calcium, or vitamin D metabolites over 3 years.

Conclusions
The use of niacin over 3 years lowered serum phosphorous concentrations but did not affect other markers of mineral metabolism in participants with CKD.
Front-line treatment of patients with chronic lymphocytic leukemia: a systematic review and network meta-analysis
Authors: Xu Yingxin , Fahrbach Kyle , Dorman Emily , Baculea Simona , Côté Sarah , Sanden Suzy van , Diels Joris 
Published: December 2017

Aim:
A systematic literature review and network meta-analysis were conducted to determine the relative efficacy and safety of interventions for treatment-naive chronic lymphocytic leukemia patients, as comparative evidence is scarce.
Materials & methods:
Relative treatment effects of progression-free survival, overall survival and safety outcomes were estimated via network meta-analysis based on data identified via systematic literature review.
Results:
Ibrutinib was superior in all pairwise comparisons for progression-free survival (probability to be better [P] range: overall population: 69–100%; fludarabine-ineligible population: 69–100%) and overall survival (P range: overall: 89–100%; fludarabine-ineligible: 91–100%) and had the highest probability of being best for all outcomes.
Conclusion:
Ibrutinib provides superior benefit in survival and safety compared with other front-line treatments of chronic lymphocytic leukemia.
Juntos, en lo fronterizo: construyendo territorios a través de los espacios de frontera
Authors: Santamarina-Macho Carlos 
Published: December 2017

<p>La frontera no debe ser interpretada únicamente como una línea de separación y protección; también puede convertirse en el espacio desde donde realidades contrapuestas, mediante las posibilidades creativas del conflicto, avancen hacia metas comunes. Partiendo del mito fronterizo, el artículo muestra algunas situaciones y experiencias en las cuales el concepto puede seguir siendo útil en la actualidad para el conocimiento, la interpretación e, incluso, la construcción de territorios.</p>
Modernisasi Lembaga Pendidikan Pesantren
Authors: Bashori Bashori 
Published: December 2017

Pesantren is an Islamic institution which has the advantage of both aspects of the scientific tradition as well as the transmission side and the intensity of the Muslims. The rise of globalization has threatened the existence of pesantren, so it appears the idea of modernizing the environment of schools to the challenges of social transformation needs. But many people worry about the idea of modernization-oriented pesantren of the present can affect idenitas and primary function of pesantren education institutions. Therefore, it is important we discus and further analyze how the role of the modernization of pesantren education institutions today. Pesantren merupakan lembaga pendidikan Islam yang memiliki keunggulan baik dari aspek tradisi keilmuannya maupun sisi transmisi dan intensitas umat Islam. Derasnya arus globalisasi telah mengancam eksistensi pesantren sehingga muncul gagasan modernisasi dilingkungan pesantren demi menjawab tantangan kebutuhan transformasi sosial. Akan tetapi banyak kalangan mengkhawatirkan tentang gagasan modernisasi pesantren yang berorientasi kekinian dapat mempengaruhi idenitas dan fungsi pokok lembaga pendidikan pesantren. Oleh karena itu, perlu kiranya kita membahas dan menganalisis lebih jauh bagaimana peranan modernisasi lembaga pendidikan pesantren saat ini.
XÂY DỰNG QUY TRÌNH ĐỊNH LƯỢNG FLURBIPROFEN TRONG VIÊN NÉN BAO PHIM 100 MG BẰNG PHƯƠNG PHÁP SẮC KÝ LỎNG HIỆU NĂNG CAO GHÉP ĐẦU DÒ DIODE-ARRAY
Authors: Nguyen Thi Thanh Binh , Nguyen Thanh Hai , Dang Ngoc Anh , Tran Mai Anh 
Published: December 2017

Trong nghiên cứu này chúng tôi đã xây dựng được quy trình định lượng flurbiprofen trong viên nén bao phim 100 mg bằng phương pháp sắc ký lỏng hiệu năng cao ghép đầu dò diode-array theo hướng dẫn của Cơ quan quản lý thuốc châu Âu và Hội nghị quốc tế về hài hoà hoá các yêu cầu kỹ thuật để đăng ký dược phẩm sử dụng trên người. Pha tĩnh được sử dụng là cột silicagel pha đảo C8 (5 μm, 120 Å, 4,6×150 mm), pha động là hỗn hợp acetonitril : nước : acid acetic băng với tỷ lệ 65 : 32,5 : 2,5, tốc độ dòng 1 ml/phút. Mẫu được tiêm với thể tích 10 µl, thời gian sắc ký 8 phút, bước sóng phát hiện 247 nm. Thời gian lưu của flurbiprofen là 3,73 phút. Kết quả thực nghiệm cho thấy trong khoảng nồng độ từ 2 – 20 μg/ml, có sự tương quan tuyến tính chặt chẽ giữa diện tích pic y (mAU.min) và nồng độ dung dịch x (μg/ml) theo phương trình y = 0,680x với hệ số xác định R2 = 0,9993. Giới hạn phát hiện và giới hạn định lượng lần lượt là 0,05 và 0,15 μg/ml. Phương pháp đảm bảo tính đặc hiệu với flurbiprofen, có độ đúng và độ chính xác tốt với tỷ lệ phục hồi ≤ 100 ± 2%, độ lệch chuẩn tương đối của độ lặp lại ≤ 1,71%, độ lệch chuẩn tương đối của độ chính xác trung gian ≤ 2,34%.
KARAKTERISASI ISOLAT BAKTERI FIBRINOLITIK WU 021055* ASAL PERAIRAN PANTAI PAPUMA, JEMBER
Authors: Sri Pananjung Ajeng Maharani , Ulfa Evi Umayah , Senjarini Kartika , Arimurti Sattya 
Published: December 2017

A blood clot (thrombus) in a blood stream is formed due to a circulatory system imbalance in the hemostasis which results in plug of blood vessels. The suppliy of nutrients and oxygen to the tissues is inhibited (ischemia) by the accumulation of thrombus and embolus in the blood vessel. This prosses is the main cause for further atherotrombotic diseases such as myocardial infraction and cerebral infraction. This disease could be overcome by thrombolytic therapy by using fibrinolytic protease enzyme. Fibrinolytic activity of protease enzymes have been studied from various species of bacteria. Bacterial isolate of WU 021055* obtained from Papuma coastal waters has demonstrated fibrinolytic activity. This research was aimed to identify the bacterial isolate through morphological characterization (colony and cell morphology), physiological characterization (indole test, carbohydrates fermentation test (glucose, lactose, sucrose and fructose), catalase test, starch hydrolysis test, and the pH effect test), and molecular identification using 16S rRNA. Based on those characterizations, the bacterial isolate of WU 021055* shows a high similarity to Bacillus aerius.Keywords: Atherotrombosis, fibrinolytic, identification, characterization, bacteria ABSTRAKBekuan darah (trombus) dalam peredaran darah terbentuk akibat ketidakseimbangan sistem sirkulasi dalam hemostasis yang menyebabkan penyumbatan pembuluh darah. Akumulasi trombus dan embolus pada pembuluh darah mengakibatkan suplai nutrisi dan oksigen ke jaringan terhambat (iskemia) dan bahkan kematian jaringan (infark). Pembentukan ini merupakan etiologi dari penyakit aterotrombosis seperti infark miokard dan infark serebral. Penyakit akibat trombosis ini dapat diatasi dengan terapi trombolitik dengan enzim protease fibrinolitik. Aktivitas enzim protease fibrinolitik telah diteliti dari berbagai spesies bakteri. Isolat bakteri WU 021055* asal perairan pantai papuma tampak memiliki aktivitas fibrinolitik. Pada penelitian ini dilakukan identifikasi isolat bakteri melalui karakterisasi morfologi (morfologi koloni dan sel), karakterisasi fisiologis (uji indol, uji fermentasi karbohidrat (glukosa, laktosa, sukrosa dan fruktosa), uji katalase, uji hidrolisis pati, dan uji pengaruh pH), dan identifikasi secara molekuler menggunakan 16S rRNA. Berdasarkan karakterisasi morfologi, fisiologi, dan marker 16S rRNA, isolat bakteri WU 021055* menunjukkan kemiripan yang tinggi dengan Bacillus aerius.Kata kunci: Aterotrombosis, fibrinolitik, identifikasi, karakterisasi, bakteri
AKTIVITAS LIGNINOLISIS DARI BASIDIOMYCETES YANG DAPAT DIPAKAI UNTUK BIODEGRADASI DIOKSIN
Authors: Nugroho Nuki Bambang 
Published: December 2017

Chemical compounds belonging to dioxin group are known to be highly toxic environmental pollutant. Polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran are produced during organic materials burning process. Pentachlorophenol, a compound similar to dioxin, is widely used as wood preservative, fungicide, bacteriocide, herbicide, algicide and insecticide. Some white-rot fungi have potential to produce lignin degrading enzyme and degrade dioxin compounds. The diversity of white-rot fungi in Indonesia provides potential source for environmental pollutant-degrading microorganisms. In this study, basidiomycetes were isolated from fruiting body and rotted wood samples which were collected from seven provinces in Indonesia. Three hundred seventy basidiomycete isolates were screened for dioxin degrading activity using dye-decolorization method. The result indicated that sixty isolates had dioxin degrading activity, three of which showed significant activity.Keywords: Ligninolytic, basidiomycetes, biodegradation, dioxin, fungus ABSTRAKSenyawa-senyawa kimia dalam kelompok dioksin telah diketahui sebagai polutan lingkungan yang sangat beracun. Dibenzo-p-dioksin terpoliklorinasi dan dibenzofuran terpoliklorinasi dihasilkan selama proses pembakaran bahan-bahan organik. Pentaklorofenol, suatu senyawa mirip dioksin, banyak digunakan sebagai pengawet kayu, fungisida, bakterisida, herbisida, algisida dan insektisida. Beberapa jamur pelapuk putih memiliki potensi untuk menghasilkan enzim pengurai lignin dan mendegradasi senyawa-senyawa dioksin. Keanekaragaman jamur pelapuk putih di Indonesia yang tinggi merupakan sumber potensial mikroorganisme pengurai polutan lingkungan. Pada kajian ini, basidiomisetes diisolasi dari sampel-sampel tubuh buah dan kayu lapuk yang diambil dari tujuh provinsi di Indonesia. Tiga ratus tujuh puluh isolat basidiomisetes telah diseleksi aktivitasnya sebagai pendegradasi dioksin. Metode dye-decolorization digunakan pada seleksi ini. Hasil seleksi menunjukkan bahwa enam puluh isolat basidiomisetes memiliki aktivitas sebagai pendegradasi dioksin, tiga isolat di antaranya menunjukkan aktivitas tertinggi.Kata kunci: Ligninolisis, basidiomisetes, biodegradasi, dioksin, jamur