bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of perception of illness on quality of life in juvenile systemic lupus erythematosus
Authors: Şahin Nihal , Uçak Kübra , Atamyıldız Uçar Sıla , Sönmez Hafize Emine , Sözeri Betül 
Published: September 2024

Objective Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs, notably the skin, joints, and kidneys. The primary goal in managing SLE is to enhance patients’ quality of life (QoL). Illness perception can influence QoL in patients with chronic disease. We assessed illness perception in juvenile SLE (jSLE) patients and its effect on patient’s and parental QoL. Method Patients diagnosed with jSLE according to the SLICC 2012 criteria between January and November 2023 were included. Patients’ illness perceptions were gaged using the brief illness perception questionnaire (B-IPQ), while patient’s and parental QoL were evaluated using PedsQL and WHOQOL- BREF, respectively. Results The study comprised 32 patients and 32 parents, predominantly female (78.1%). Musculoskeletal involvement was the most common (65.6%), followed by mucocutaneous (59.4%), renal, and hematological involvement (50% each). Neuropsychiatric involvement was absent. The median SLEDAI-2K score at the last outpatient clinic visit, which was documented in the patient’s file was 2 (0–18) and was not correlated with the B-IPQ score (r = 0.121, p = .51). A significant negative correlation was found between B-IPQ and patient QoL, indicating poorer QoL in patients with negative illness perceptions (r = −0.576, p < .001). No correlation was observed between parental QoL and B-IPQ ( p => .05). Of note, 56.3% of patients had poor QoL, scoring below the PedsQL cut-off, while 43.8% of parents had poor QoL for general health, scoring below the WHOQOL-BREF cut-off for general health. Conclusion Although disease perception did not correlate with disease activation in jSLE, it significantly impacted patient QoL. Enhancing patients’ perceptions of jSLE may improve their overall QoL.
A Descriptive Study to Assess Neonatal Stress Behavior Among Preterm Neonates Admitted in NICU, Nehru Hospital, PGIMER, Chandigarh
Authors: Dhingra Sanjoli , Choudhary Anupama , Mukhopadhyay Kanya , Chopra Seema 
Published: September 2024

Background Preterm neonates are repeatedly exposed to many stressors in initial days of life such as environmental stressor (light and noise) and caregiver interventions (weighing, oral and tracheal suctioning, drawing blood samples, etc.). If preterm neonates’ stress is not recognized and left untreated, there may be long-term effects. Objective To assess the neonatal stress behavior among preterm neonates admitted in neonatal intensive care unit (NICU), Nehru Hospital, PGIMER, Chandigarh. Methodology A descriptive study was conducted to assess neonatal stress behavior among preterm neonates admitted in NICU, Nehru Hospital, PGIMER, Chandigarh. Ethical clearance was taken from Institutional Ethics Committee of PGIMER, Chandigarh. Total 100 participants admitted in NICU during the period of July–December 2022 were enrolled for the study using consecutive sampling technique. Data was collected by interviewing mother using interview schedule. It comprised of sociodemographic cum clinical profile of the preterm neonate. Observation was made by using—(a) modified infant positioning assessment tool (IPAT), (b) neonatal stress scale, and (c) preterm neonate’s behavior assessment scale. Results The present study shows that 88% of the preterm neonates show moderate stress and 70% of preterm neonates exhibit suspected abnormal behavioral response in terms of autonomic visceral subsystems, while 54% of the preterm neonates show suspected abnormal behavioral response in terms of state regulation attention interaction subsystem. Conclusion The present study concluded that moderate stress level and suspected abnormal behavioral response were found among hospitalized preterm neonates.
Raltitrexed Chemotherapy Regimen Plus Bevacizumab as Second-Line Treatment for Metastatic Colorectal Cancer: A Prospective Multicenter Phase II Trial
Authors: Li Sheng , Li Xiaoyou , Zhu Qianni , Gao Jin , Zhu Chunrong , Zhu Liangjun 
Published: September 2024

Objectives Clinical studies have shown that bevacizumab plus chemotherapy significantly improves efficacy in metastatic colorectal cancer (mCRC). This prospective study aims to investigate the efficacy and safety of changing second-line treatment to raltitrexed-based chemotherapy regimens plus bevacizumab in mCRC patients who have failed the first-line fluorouracil-based chemotherapy regimen with or without bevacizumab/cetuximab. Methods This is a prospective, open-label, multicenter, phase II clinical study. A total of 100 patients with mCRC after failure of the first-line fluorouracil-based chemotherapy regimen with or without bevacizumab/cetuximab were enrolled from November 2016 to October 2021, and received second-line raltitrexed-based chemotherapy regimen plus bevacizumab. Patients were treated for 6 cycles, and efficacy evaluation over stable disease were followed by maintenance treatment of bevacizumab and raltitrexed until disease progression or intolerable toxicity. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival (OS), objective response rate (ORR), disease control rate (DCR), safety, and toxicity. Results Ninety-four patients were treated with SALIRI (raltitrexed + irinotecan) plus bevacizumab, and six patients with SALOX (raltitrexed + oxaliplatin) plus bevacizumab. Median PFS was 8.4 (95% CI: 6.2-11.0) months, including 8.2 (95% CI 6.2, 11.0) months in the SALIRI group and 11.6 (95% CI 3.1, NA) months in the SALOX group. Median OS was 17.6 (95% CI 15.2, 22.0) months in the SALIRI group and 17.1 (95% CI 4.1, NA) months in the SALOX group. ORR and DCR were 25.5% and 87.2% in the SALIRI group, and 33.3% and 83.3% in the SALOX group, respectively. A low incidence of grade 3-4 adverse events was observed. Conclusions Raltitrexed-based chemotherapy regimens plus bevacizumab improved survival duration in mCRC patients with failed first-line therapy. Therefore, treatment with raltitrexed-based chemotherapy regimens plus bevacizumab could be a superior therapeutic option for second-line chemotherapy in mCRC ( ClinicalTrials.gov registration number: NCT03126071).
Safety of intramuscular tixagevimab-cilgavimab (Evusheld®) administration in patients at risk of iatrogenic haematoma due to haematological disorders
Authors: Malherbe Jacques A. J. , Misko Jeanie , Jayawardena Nishani K. , Rawlins Matthew D. M. , Manning Laurens , Purtill Duncan 
Published: September 2024

Introduction Traditionally, intramuscular (IM) injections have been avoided in patients with haematological diseases due to the risk of iatrogenic haematoma. Tixagevimab-cilgavimab (Evusheld®) is a novel monoclonal antibody combination used as preexposure prophylaxis against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for those at highest risk of severe infections. It is delivered as two separate IM injections (1.5 mL each). Patients with haematological disease are at higher risk for severe SARS-CoV-2 infections, which may be partially abrogated by the prophylactic inoculation of tixagevimab-cilgavimab. Methods A combined retrospective and prospective study of patients under the haematology service at a large metropolitan hospital receiving tixagevimab-cilgavimab was conducted. Tixagevimab-cilgavimab was administered IM to all patients, with platelet and factor replacement provided according to local protocols. Patients completed a numerical pain score daily for seven days following the injection, with scores ≥4/10 prompting an ultrasound to identify iatrogenic gluteal haematomas. Results The study recruited 131 patients; 66 patients were thrombocytopenic, including 10 patients with a platelet count <30 × 109/L. Fourteen patients (10.7%) received a single platelet transfusion prior to tixagevimab-cilgavimab administration, while two patients received fresh frozen plasma. No gluteal haematomas were identified, and only two patients reported an initial pain score of ≥4/10. Conclusions The intramuscular administration of tixagevimab-cilgavimab in patients with haematological diseases was well tolerated and was not associated with iatrogenic haematoma.
Local and systemic side effects of COVID-19 vaccine in Tunisian cancer patients: A prospective single center study
Authors: Ben Kridis Wala , Boudawara Olfa , Khanfir Afef 
Published: September 2024

Objective We aimed to evaluate the local and systemic side effects of the COVID-19 vaccine in cancer patients. Methods we conducted a cross-sectional study including cancer patients treated at Habib Bourguiba Hospital in Sfax, Tunisia between January and March 2022. Patients should have received at least 1 dose of a COVID-19 vaccine. Results We interviewed a total of 106 patients, of which 80.2% were actively treated. Mean age was 52.52. Patients were vaccinated by the Pfizer/BioNTech in 59.8% and the Oxford/AstraZeneca in 22.5%. The most frequent grade 1 or 2 adverse events occurring within 7 days were: pain at injection site (71.7%) and fatigue (38.7%). Only 2 patients developed grade 3 toxicity following vaccination. The most systemic side effects were fatigue (35.8%), fever (25.4%), headache (16.9%) and arthralgia (15.1%). They were more common after the first dose of Oxford/AstraZeneca vaccine compared to the Pfizer/BioNTech vaccine (69.6% vs 42.6%; p = 0.03). Risk of any grade toxicity (local or systemic) following the first dose was correlated with female sex (p = 0.033). Conclusion Our study showed that systemic side effects were more common after the first dose of Oxford/AstraZeneca vaccine compared to the Pfizer/BioNTech vaccine in cancer patient, with the predominance of any grade of local or systemic toxicity in women.
Bond strength empirical-mathematical equation and optimization of Al1050/AISI304 bilayer sheets fabricated by cold roll bonding method
Authors: Atifeh Seyed Mahdi , Sedighi Mohammad , Hashemi Ramin 
Published: September 2024

Nowadays, composite sheets have been increasingly developed in various applications due to their better corrosion and wear resistance as well as higher strength and formability. Of these, Al/SS bilayer sheets have been used in the food and automotive industries due to their favorable performance and low cost. In this research, the bonding strength of Al1050/AISI304 bilayer sheets fabricated by cold roll bonding has been investigated experimentally. At first, the design of the experiment was carried out using the surface response method, taking into account the thickness of the layers and the rolling reduction ratio, bilayer sheet using the rolling bonding method. In this research, for the first time, the bonding strength of Al/SS bilayer sheets fabricated by cold rolling bonding method and its optimization have been investigated. The bond strength was extracted using T peeling test. Then, using the linear regression method, a mathematical-experimental relationship was presented to obtain the peeling strength in terms of the thickness of the layers and the reduction ratio. The obtained results were analyzed using statistical methods and the table of coefficients, the table of residuals and the analysis of variance table of the data related to bond strength were presented and the adequacy of the presented model was examined. The results showed that by reducing the reduction ratio in the cold rolling process and also reducing the initial thickness of the sheets, the bond strength of the bilayer sheet has decreased. Then, bond strength optimization was done as a function of input parameters. The results indicated that the bonding strength reached its maximum level at the thickness of the aluminum layer = 2 mm, the thickness of the stainless-steel layer = 1.3 mm and reduction = 75%.
Multi-experimental seismic analysis of low-rise thin reinforced concrete wall building with unconnected elastomeric isolators using real-time hybrid simulations
Authors: Castillo Torres Bryan , Artunduaga Triviño Eivar A , Marulanda Casas Johannio , Ortiz Albert R , Thomson Peter 
Published: September 2024

In response to the pressing need for housing and streamlining construction processes, the building industry has embraced innovative construction techniques. One such method, known as the Industrialized Housing Construction (IHC) system, departs from traditional framing systems by utilizing thin-reinforced concrete walls (TRCW). These TRCWs, characterized by high flowability and rapid strength gain, enable quick and efficient monolithic construction of walls and slabs. However, challenges have arisen regarding the structural behavior of these elements, potentially compromising their seismic performance. Given the significant seismic risk, there is a compelling need to develop resilient buildings by using this cost-efficient structural system. This study proposes the use of passive control systems such as base isolation to address this problem. While base isolation has proven effective in other countries, its feasibility in structures using TRCW and its performance during actual seismic events warrants further investigation. This paper presents an innovative approach using Multi-Axial Real-Time Hybrid Simulation (M-RTHS), which combines numerical and experimental components to gain deeper insights into the seismic response of low-rise TRCW buildings with base isolation using unconnected fiber-reinforced elastomeric isolators (U-FREIs). The methodology is detailed and includes the division of the structure into numerical and experimental segments and the use of transfer systems to replicate real seismic excitations, including those from El Centro (USA, 1940), Pizarro (Colombia, 2004), Chihuahua (Mexico, 2013), Loma Prieta (USA, 1989), and Kobe (Japan, 1995), with a maximum amplitude of 7.36 [Formula: see text] (0.75 g). The results highlight a remarkable reduction in upper structure floor drifts of over 57.47%, the characterization of the behavior and energy dissipation of each experimental specimen, and the optimal evaluation of M-RTHS. This research paves the way for improving the seismic resistance of buildings in regions prone to seismic activity, especially those using innovative construction methods such as TRCW.
Endovascular Management of a Chronic Type A Aortic Dissection: Case Report
Authors: Al-Osail Emad M. , Le Houérou Thomas , Gaudin Antoine , Costanzo Alessandro , Fabre Dominique , Haulon Stephan 
Published: September 2024

Iatrogenic type A aortic dissection following thoracic endovascular aortic repair (TEVAR) is a life-threatening complication, with reported incidence rates ranging from 1.3% to 6.8%. Urgent open surgical repair is recommended when this complication occurs. In the present case, surgery was not performed at the onset of symptoms in a 61-year-old female initially treated with TEVAR for an acute type B aortic dissection. She was referred to our center 3 months later with a chronic type A dissection with the primary entry tear located in the arch. In this very fragile patient, we performed an endovascular repair with an arch branched endograft in combination with surgical debranching of the right carotid and left subclavian arteries. Clinical Impact Branched endograft exclusion of chronic type A dissections resulting from a TEVAR complication is a minimally-invasive approach to consider in very fragile patients to mitigate the potential risks associated with conventional open surgical repair.
Alternative hybrid access in endovascular neurosurgery: Scoping review and technical considerations
Authors: Costa Matias , Vivanco-Suarez Juan , O’Leary Sean , D’Souza Preston , Nunna Ravi , Luzzi Sabino , Casanova-Martinez Daniel , Patel Akshal 
Published: September 2024

Background The common femoral artery and radial artery constitute the most common access sites in contemporaneous endovascular neurosurgery. Oftentimes, it may be impossible to reach the vascular target safely due to different circumstances, necessitating alternative approaches. We aim to review these “last resource” access sites described in the literature, focusing on the technical aspects as a convenient reference. Methods We performed a comprehensive literature search of PubMed capturing articles from 1958 to 2022. Results We identified nine alternative approaches for endovascular access, after excluding direct carotid stick: superficial temporal artery access in 60 patients, calvarial foramina access in five patients, occipital artery access in seven patients, middle meningeal artery access in six patients, vertebral artery access in 23 patients and external carotid artery, internal maxillary artery, facial artery or lingual artery in 40 patients. Indications for the use of alternative access points included tortuous or occluded vessels, small vessel calibers, or anatomic variation. Pathologies treated included dural arteriovenous fistulas, arteriovenous malformations, intracranial aneurysms, acute stroke, and intracranial stenosis. Diagnostic brain angiograms were also performed. Conclusions Alternative vascular access routes expand the proceduralists' toolkit, enhancing the capability to manage complex cerebrovascular interventions. This review advocates for a broader understanding and consideration of these techniques, given their potential to significantly increase treatment options in neuroendovascular surgery.
Psychological distress and coping strategies in breast cancer patients under neoadjuvant therapy: A systematic review
Authors: Omari Majid , Amaadour Lamiae , El Asri Achraf , Benbrahim Zineb , Mellas Nawfel , El Rhazi Karima , Ragala Mohammed El Amine , El Hilaly Jaouad , Halim Karima , Zarrouq Btissame 
Published: September 2024

Background: During neoadjuvant therapy (NAT), patients with locally advanced breast cancer (LABC) experience psychological distress (PD) and adopt appropriate coping strategies. Objective: This systematic review aimed to examine the prevalence and changes in PD and coping strategies in patients with LABC during NAT and to evaluate effective interventions to reduce their PD. Design: Quantitative (cross-sectional, longitudinal, and interventional) and qualitative studies reporting PD and coping strategies related to NAT during LABC were included. Data sources and methods: PubMed, Cochrane Library, Scopus, ScienceDirect, Wiley Online Library, and Web of Science databases were consulted to gather relevant literature from the first publications until July 25, 2023. Selection was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: A total of 41 articles were included, of which four were qualitative. The main results showed that the prevalence of depression before NAT ranged from 0% to 46% and that of anxiety from 5.5% to 54%. After NAT, the prevalence of depression ranged from 40% to 78.5% and anxiety accounted for 27%. Additionally, PD decreased during NAT. The main determinants of PD were perceived social support, living in joint families, being affected by COVID-19 infection, delays in diagnosis, and starting neoadjuvant treatment. For coping strategies, after NAT, “resigned coping” decreased, whereas “social support” increased, and active coping strategies were correlated with better PD. Some interventions found a reduction in PD, such as a mobile health application, fasting-mimicking diet, relaxation training, and guided imaging. Conclusion: These findings highlight the importance of considering PD and coping strategies in patients with LABC from diagnosis to the end of NAT. The results suggest that effective psychological interventions should be implemented.
Pregnancy outcomes in renal transplant recipients: A systematic review and meta-analysis
Authors: Mustafa Muhammad Saqlain , Noorani Amber , Abdul Rasool Aniqa , Tashrifwala Fatema Ali Asgar , Jayaram Shubha , Raja Sandesh , Jawed Fatima , Siddiq Muhammad Usama , Shivappa Sowmya Govindanahalli , Hameed Ishaque , Dadana Sriharsha 
Published: September 2024

Background: Kidney transplantation is a superior treatment for end-stage renal disease (ESRD), compared with hemodialysis, offering better quality of life and birth outcomes in women with ESRD and lower fertility rates. Objectives: To investigate the pregnancy, maternal, fetal, and graft outcomes following kidney transplantation in women with ESRD and evaluate the improvements in quality of life and associated risks. Design: A systematic review and meta-analysis performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the Meta-analysis of Observational Studies in Epidemiology guidelines. Data Sources and Methods: A thorough search of multiple databases, including PubMed, Embase, Scopus, ATC abstracts, and Cochrane Central Register of Controlled Trials, was conducted to identify studies that analyzed pregnancy outcomes in kidney transplant patients. The search was conducted from the inception of each database to January 2023. Results: The study reviewed 109 studies that evaluated 7708 pregnancies in 5107 women who had undergone renal transplantation. Of these, 78.48% resulted in live births, 9.68% had induced abortion, and 68.67% had a cesarean section. Miscarriage occurred in 12.54%, preeclampsia in 20.87%, pregnancy-induced hypertension in 24.30%, gestational diabetes in 5.08%, and preterm delivery in 45.30% of cases. Of the 853 recipients, 123 had graft loss after pregnancy and 8.06% suffered acute rejection. Conclusion: Pregnancy after kidney transplantation is associated with risks for mother and fetus; however, live births are still possible. In addition, there are reduced overall risks of stillbirths, miscarriages, neonatal deaths, and gestational diabetes. Registration: PROSPERO (CRD42024541659).
Diabetic Peripheral Neuropathy: Emerging Treatments of Neuropathic Pain and Novel Diagnostic Methods
Authors: Røikjer Johan , Borbjerg Mette Krabsmark , Andresen Trine , Giordano Rocco , Hviid Claus Vinter Bødker , Mørch Carsten Dahl , Karlsson Pall , Klonoff David C. , Arendt-Nielsen Lars , Ejskjaer Niels 
Published: September 2024

Background: Diabetic peripheral neuropathy (DPN) is a prevalent and debilitating complication of diabetes, often leading to severe neuropathic pain. Although other diabetes-related complications have witnessed a surge of emerging treatments in recent years, DPN has seen minimal progression. This stagnation stems from various factors, including insensitive diagnostic methods and inadequate treatment options for neuropathic pain. Methods: In this comprehensive review, we highlight promising novel diagnostic techniques for assessing DPN, elucidating their development, strengths, and limitations, and assessing their potential as future reliable clinical biomarkers and endpoints. In addition, we delve into the most promising emerging pharmacological and mechanistic treatments for managing neuropathic pain, an area currently characterized by inadequate pain relief and a notable burden of side effects. Results: Skin biopsies, corneal confocal microscopy, transcutaneous electrical stimulation, blood-derived biomarkers, and multi-omics emerge as some of the most promising new techniques, while low-dose naltrexone, selective sodium-channel blockers, calcitonin gene-related peptide antibodies, and angiotensin type 2 receptor antagonists emerge as some of the most promising new drug candidates. Conclusion: Our review concludes that although several promising diagnostic modalities and emerging treatments exist, an ongoing need persists for the further development of sensitive diagnostic tools and mechanism-based, personalized treatment approaches.