bluuebunny/crossref_metadata_2025_split huggingface dataset:
Galectin‐3 is Persistently Increased in Early Rheumatoid Arthritis (RA) and Associates with Anti‐CCP Seropositivity and MRI Bone Lesions, While Early Fibrosis Markers Correlate with Disease Activity
Authors: Issa S. F. , Christensen A. F. , Lindegaard H. M. , Hetland M. L. , Hørslev‐Petersen K. , Stengaard‐Pedersen K. , Ejbjerg B. J. , Lottenburger T. , Ellingsen T. , Pedersen J. K. , Junker K. , Svendsen A. , Tarp U. , Østergaard M. , Junker P. 
Published: October 2017

AbstractGalectin‐3 has been suggested as a pro‐inflammatory mediator in animal arthritis and rheumatoid arthritis (RA). We aimed to study the serum level of galectin‐3 in patients with newly diagnosed RA and associations with disease profile, Magnetic resonance imaging (MRI) findings and seromarkers of synovial matrix inflammation. One hundred and sixty DMARD naïve patients newly diagnosed with RA were included (CIMESTRA study). Clinical, serological and imaging data were recorded before treatment and at 6 weeks, 3 and 12 months. Galectin‐3 and hyaluronan (HYA) were measured by ELISA (R&D and Corgenix, USA), and the N‐terminal propeptide of type III collagen (PIIINP) by radioimmunoassay (Orion Diagnostica, Finland). One hundred and nineteen, 87 and 60 blood donors served as controls for galectin‐3, HYA and PIIINP, respectively. Baseline galectin‐3 was significantly elevated in anti‐CCP positive (4.2 μg/l IQR [3.6;6.1]) patients as compared with anti‐CCP negatives (4.0 μg/l [2.6;4.9], P = 0.05) and controls (3.8 μg/l [3.0;4.8], P < 0.01). During treatment, galectin‐3 remained elevated, but increased transiently with peak values at 6 weeks. Galectin‐3 correlated with baseline smoking, anti‐CCP, and with MRI erosion score after 1 year of follow‐up. HYA and PIIINP were elevated (P < 0.001) irrespective of anti‐CCP status and correlated positively with synovitis assessed clinically and by MRI. HYA and PIIINP did not correlate with galectin‐3. These observations indicate that HYA and PIIINP mainly reflect expansive synovitis proliferation while galectin‐3 is more closely linked to autoimmunity, smoking and joint destructive processes.
When the Going Gets Tough: Issue Environments and Gendered Negativity Strategies*
Authors: Nelson Kjersten 
Published: October 2017

ObjectiveIn theory, gender expectations may influence candidate's negativity strategies. However, these gender expectations interact with other factors, such as party expectations and the election's issue environment. This study seeks to determine if candidate gender, opponent gender, and issue environment affect negativity strategies.MethodsThe study analyzes the ads purchased by U.S. congressional candidates in the 2004 and 2008 election cycles.ResultsThe analyses show that gender and party expectations, moderated by the issue environment of the election, affect levels of negativity. Democratic women and Republican men appear to be particularly sensitive to these contextual changes.ConclusionThe results bolster other findings that gender expectations are moderated by party expectations, as well as context dependent. In addition, given that women report more reluctance to run for office based on the potential of being involved in a negative campaign, the results provide insight as to why more women are not running for office.
Comparative analyses of industrial‐scale human platelet lysate preparations
Authors: Pierce Jan , Benedetti Eric , Preslar Amber , Jacobson Pam , Jin Ping , Stroncek David F. , Reems Jo‐Anna 
Published: October 2017

BACKGROUNDEfforts are underway to eliminate fetal bovine serum from mammalian cell cultures for clinical use. An emerging, viable replacement option for fetal bovine serum is human platelet lysate (PL) as either a plasma‐based or serum‐based product.STUDY DESIGN AND METHODSNine industrial‐scale, serum‐based PL manufacturing runs (i.e., lots) were performed, consisting of an average ± standard deviation volume of 24.6 ± 2.2 liters of pooled, platelet‐rich plasma units that were obtained from apheresis donors. Manufactured lots were compared by evaluating various biochemical and functional test results. Comprehensive cytokine profiles of PL lots and product stability tests were performed. Global gene expression profiles of mesenchymal stromal cells (MSCs) cultured with plasma‐based or serum‐based PL were compared to MSCs cultured with fetal bovine serum.RESULTSElectrolyte and protein levels were relatively consistent among all serum‐based PL lots, with only slight variations in glucose and calcium levels. All nine lots were as good as or better than fetal bovine serum in expanding MSCs. Serum‐based PL stored at −80°C remained stable over 2 years. Quantitative cytokine arrays showed similarities as well as dissimilarities in the proteins present in serum‐based PL. Greater differences in MSC gene expression profiles were attributable to the starting cell source rather than with the use of either PL or fetal bovine serum as a culture supplement.CONCLUSIONUsing a large‐scale, standardized method, lot‐to‐lot variations were noted for industrial‐scale preparations of serum‐based PL products. However, all lots performed as well as or better than fetal bovine serum in supporting MSC growth. Together, these data indicate that off‐the‐shelf PL is a feasible substitute for fetal bovine serum in MSC cultures.
Evaluation of reticulocyte hemoglobin content (RET‐He) in the diagnosis of iron‐deficient erythropoiesis in dogs
Authors: Fuchs Jannika , Moritz Andreas , Grußendorf Esther , Lechner Jörg , Neuerer Felix , Nickel Rafael , Rieker Thomas , Schwedes Claudia , DeNicola Dennis B. , Russell James , Bauer Natali 
Published: October 2017

AbstractBackgroundReticulocyte hemoglobin content provided by the Siemens ADVIA (CHr) is an established marker of iron deficiency. TheIDEXXProCyte Dx hematology analyzer now provides a similar variable, reticulocyte hemoglobin equivalent (RET‐He).ObjectivesThe objective was to evaluateRET‐Heand its diagnostic utility in dogs, and to calculate a cutoff value for diagnosing iron‐deficient erythropoiesis (IDE). Furthermore, the prevalence ofRET‐Hevalues below this cutoff value was established.MethodsOne hundred and seventy‐one CBCs of healthy dogs were used to establish aRI. Stability ofRET‐Hewas evaluated by repeated measurements over 48 hours (n= 10). The 25‐run coefficient of variation (CV) was calculated, and correlation and bias between measurements ofRET‐HeandCHr were assessed (n= 190). A cutoff value for diagnosingIDEwas calculated. The utility ofRET‐Hein the detection ofIDEwas evaluated in 123 dogs. The prevalence of lowRET‐Hevalues was assessed retrospectively in a multicenter study (2012–2014) under participation of 7 veterinary clinics.ResultsReticulocyte hemoglobin equivalent with anRIof 22.2 to 28.6 pg was statistically stable over 48 hours (P= .10). TheCVwas 1.8%. A fair correlation (ρ = 0.74) betweenRET‐HeandCHr with a small bias of −0.6 pg was found. The cutoff value for diagnosingIDEwas 20.9 pg (sensitivity: 85%; specificity: 99%). The prevalence ofRET‐Hevalues below 20.9 pg was 10.3% (1084/10,553 dogs).ConclusionsRET‐Heon the ProCyte Dx is a precise screening tool in dogs to detect iron‐deficient erythropoiesis.
Correlation between plasma fibrinogen and FIBTEM thromboelastometry during liver transplantation: a comprehensive assessment
Authors: Blasi A. , Sabate A. , Beltran J. , Costa M. , Reyes R. , Torres F. 
Published: October 2017

BackgroundThromboelastometry may reduce red blood cell (RBC) transfusion in liver transplantation (LT). Fibrinogen concentration is a primary determinant of FIBTEM maximum clot firmness (MCF), but several factors could affect the correlation between FIBTEM MCF and fibrinogen values. We aimed to investigate (1) the concordance between fibrinogen level and FIBTEM MCF and (2) the association of fibrinogen level and FIBTEM MCF with RBC transfusion during LT.MethodsA post hoc analysis of data from a randomized, multicentre, double‐blind, saline/fibrinogen trial was used (NCT01539057). A total of 86 adult patients were included.ResultsThe Lin concordance coefficient (LCC) between FIBTEM MCF and fibrinogen levels with the model formula 1·3679 + 0·05414* FIBTEM MCF was poor overall (LLC [95% CI]: 0·387 [0·340 to 0·432]) and moderate for the preperfusion period (LLC [95% CI]: 0·789 [0·747 to 0·824]), but very poor for the postreperfusion period (LLC [95% CI] 0·170 [0·105 to 0·233]). The model assessed for RBC transfusion for FIBTEM MCF showed an area under the curve of 0·788 [0·745‐0·832]. Patients with FIBTEM MCF values <8 mm had a significantly higher likelihood of receiving RBC than patients with higher values. (OR [95% CI]: 2·08 [1·30‐3·33], P = 0·002). FIBTEM MCF values over 10 mm do not appear to reduce the likelihood of RBC transfusion.ConclusionFIBTEM MCF is not a good indicator of plasma fibrinogen values after graft reperfusion. FIBTEM MCF >8 mm during the LT procedure is associated with less RBC transfusion. FIBTEM MCF values over 10 mm could lead to unnecessary fibrinogen administration.
Comparison of 2 training programs for basic laparoscopic skills and simulated surgery performance in veterinary students
Authors: Chen Chi‐Ya , Ragle Claude A. , Lencioni Rachael , Fransson Boel A. 
Published: October 2017

AbstractObjectiveTo compare the effects of 2 training curricula on laparoscopic skills and performance of simulated surgery in veterinary students.Study designProspective study.Sample populationVeterinary students (n = 33) with no prior hands‐on experience in minimally invasive surgery.MethodsBasic laparoscopic skills (BLS) were assessed based on 5 modified McGill inanimate system for training and evaluation of laparoscopic skills. Motion metrics and an objective structured assessment of technical skills (OSATS) were used to evaluate surgical skills during a simulated laparoscopic cholecystectomy performed in an augmented reality simulator. Students were randomly assigned to either skill‐based (group A) or procedural‐based (group B) training curriculum. Both tests were performed prior to and after a 10‐session training curriculum.ResultsPost‐training BLS results were improved in both training groups (P < .001). Seven participants completed both presimulated and postsimulated laparoscopic cholecystectomy, preventing paired analysis. Based on motion metrics analysis, participants completed tasks in a shorter time (P = .0187), and with better economy of movement (P = .0457) after training. No difference was detected in OSATS before and after training.ConclusionBoth training curricula improved BLS, but significant differences were not detected between the procedural‐based training program and basic skills training alone in veterinary students. Motion metrics such as time, economy of movement, and instrument path were superior to an OSATS, when assessing surgical performance. Further studies are needed to compare the effects of different simulators on the training of veterinarians with diverse laparoscopic surgical experience.
Tick infestation in bank voles from East Anglia
Authors: De MENDONCA Philippe Gil 
Published: October 2017

Bank voles (Clethrionomys glareolus) are widespread and abundant in the western half of Eurasia, including Great Britain. These small rodents often come into contact with domestic animals and/or humans, either directly or indirectly, and thus are an interface between sylvatic and domestic cycles for zoonotic organisms. Bank voles were live-trapped and inspected for ticks in Cambridgeshire, Essex and Suffolk from June 1999 to April 2000. Infested voles hosted between 1 and 10 ticks. Larvae were the most frequent stage. Overall prevalence estimate of tick infestation was 14.5% (95% C.I. : 8.3% to 20.7%). Prevalence estimates fluctuated with seasons. Two tick species were identified : Ixodes ricinus (larvae only) and Ixodes trianguliceps (all three stages). The aggregated distribution of ticks on their hosts suggests that co-feeding transmission of tick-borne pathogens may happen in British bank voles. Further investigations are required to improve our knowledge and understanding of the epidemiology of tick-borne diseases in East Anglia.
The Pietà in Jacob Steinhardt’s Early Œuvre
Authors: Czekanowska-Gutman Monika 
Published: October 2017

Abstract
This essay explores the Pietàs by Jacob Steinhardt, an Eastern-European Jewish artist, in connection with his involvement in the Pathetiker movement. The paper proceeds to examine them against the backdrop of German and Austrian Expressionist movements, as well as other treatments of the theme by Jewish artists. Through stylistic and iconographic analysis of Steinhardt’s Pietàs, Czekanowska-Gutman demonstrates that both of the works in question are in fact revisions of one of the most important Christian iconographic “framing themes,” which Steinhardt situates within the Jewish context and perspective. The central argument of the paper is that Steinhardt’s Pietàs address Christian audiences in their own representational conventions in order to denounce anti-Jewish violence, such as the pogroms of the time. The artist achieves this through the portrayal of Jesus and Mary as elderly Eastern European Jews (Ostjuden), using—remarkably—the visual language of anti-Jewish caricature. Finally, the paper investigates Steinhardt’s masterful use of drypoint and woodcutting techniques to visualise the suffering of Mary and her dying son.
The Oklahoma Meso-Scale Integrated Socio-Geographic Network: A Technical Overview
Authors: Jenkins-Smith Hank , Ripberger Joe , Silva Carol , Carlson Nina , Gupta Kuhika , Henderson Matt , Goodin Amy 
Published: October 2017

AbstractEstablished as a social companion to the Oklahoma Mesonet, the Oklahoma Meso-Scale Integrated Socio-Geographic Network (M-SISNet) is a network of approximately 1500 “social monitoring stations” (geolocated households) across the state of Oklahoma that provide data on household perceptions and responses to signals that are sent from agricultural, hydrological, and meteorological systems. This paper outlines the purpose and nature of the M-SISNet, with specific focus on the sample frame, protocols for recruitment, retention, and survey implementation. It concludes with example survey questions, analyses, and directions for accessing the data.
The Not-So-Marginal Value of Weather Warning Systems
Authors: Miller Benjamin M. 
Published: October 2017

AbstractKnowing the benefits of creating or expanding programs is important for determining optimal levels of investment. Yet estimates of the benefits of weather warning systems are sparse, perhaps because there is often no clear counterfactual of how individuals would have fared without a particular warning system. This paper enriches the literature and informs policy decisions by using conditional variation in the initial broadcast dates of the National Oceanic and Atmospheric Administration’s Weather Radio All Hazards (NWR) transmitters to produce both cross-sectional and fixed effects estimates of the causal impact of expanding the NWR transmitter network. Results suggest that from 1970 to 2014, expanding NWR coverage to a previously untreated county was associated with an almost 40% reduction in injuries and as much as a 50% reduction in fatalities. The benefits associated with further expansion of this system have likely declined over time.
Psychotic-like experiences in help-seeking adolescents: Dimensional exploration and association with different forms of bullying victimization – A developmental social psychiatry perspective
Authors: Catone Gennaro , Marotta Roberta , Pisano Simone , Lennox Belinda , Carotenuto Marco , Gritti Antonella , Pascotto Antonio , Broome Matthew R 
Published: October 2017

Background: Psychotic-like experiences (PLEs) are common in the general population and increase the risk of psychotic disorders. Adolescents are a high-risk group of this condition. Stressful events, such as bullying, have a role in the onset of PLEs. This study has several aims: (1) to assess PLEs in adolescents seeking help from a Child and Adolescent Mental Health Service, (2) to assess the association of PLEs with specific bullying victimization and (3) to assess difference in PLEs and victimizations by sex and age. Methods: Participants were help-seeking (HS) adolescents initially screened for PLEs. They completed an assessment including characteristics of PLEs and bullying victimization. We paid particular attention to different kinds of PLEs and victimization. Results: In total, 50 PLE-positive adolescents screened from 324 HS adolescents (15.4%) constituted the sample. Paranoia and verbal bullying were the PLEs and form of victimization most represented, respectively. Verbal bullying was strongly associated with paranoia (odds ratio (OR): 4.40, confidence interval (CI): 2.8−5.9, p < .001). Results remained significant after controlling for confounder (socio-demographic, anxiety, depression and for the latter analysis also other forms of victimization). Furthermore, social manipulation showed a strong association of paranoia and physical bullying with grandiosity. Verbal bullying was also associated with psychotic negative symptoms, but controlling for emotional symptoms and other victimization led to a reduction in the effect. Men were more involved in physical victimization and experienced grandiosity; on the contrary, late adolescents were most involved in social victimization and negative psychotic symptoms Conclusion: PLEs are relevant in HS adolescents. Bullying victimization interacts with the onset of these phenomena. In particular, verbal bullying predicted paranoia onset significantly.
The Effect of Pain Scale for functional capacity evaluations
Authors: Dornian Shelly , Short Joel A , Smith Shannon I , Townsend Lindsey A , Morassaei Sara , Forwell Susan J 
Published: October 2017

Introduction The Effect of Pain Scale is a new tool to evaluate the effect of pain on function during functional capacity evaluations. The aim was to test the clinicometric properties of the scale with clinicians familiar with the tool and workers with musculoskeletal injuries. Method The study was conducted in two stages. Stage 1 assessed clinical utility and content validity of the scale using a questionnaire for clinicians using the tool during functional capacity evaluations. In stage 2, data were collected from clients and clinicians during functional capacity evaluations and were used to assess criterion validity, inter-rater reliability, and responsiveness. Results Twelve clinicians responded to the survey on clinical utility and content validity, and data were recorded from 30 clients during their functional capacity evaluations. The tool demonstrated good clinical utility, content validity, inter-rater reliability, and criterion validity, and was responsive to the effects of pain on function as rated by both clients and clinicians. Conclusion Findings show its credibility as a tool with sound clinicometrics and establish its value for functional capacity evaluations with clients who have musculoskeletal injuries. Further testing in other clinical settings and client populations is needed to further establish the clinical value of this tool.
Improved Chondrotoxic Profile of Liposomal Bupivacaine Compared With Standard Bupivacaine After Intra-articular Infiltration in a Porcine Model
Authors: Shaw K. Aaron , Moreland Colleen , Jacobs Jeremy , Hire Justin M. , Topolski Richard , Hoyt Nathan , Parada Stephen A. , Cameron Craig D. 
Published: October 2017

Background: Increasingly, liposomal bupivacaine is being used with multimodal pain management strategies. In vitro investigations have shown decreased chondrotoxicity profiles for liposomal bupivacaine; however, there is no evidence regarding its in vivo effects. Hypothesis/Purpose: This study sought to investigate the in vivo chondrotoxicity of liposomal bupivacaine, hypothesizing that there would be increased chondrocyte viability after exposure to liposomal bupivacaine when compared with standard bupivacaine. Study Design: Controlled laboratory study. Methods: Eight juvenile, female Yorkshire cross piglets underwent a lateral stifle joint injection with either 1.3% liposomal bupivacaine or 0.5% bupivacaine. Injections were performed on one joint per animal with no injection to the contralateral knee, which served as the control. Chondrocyte viability was assessed 1 week after injection with a live-dead staining protocol and histologic examination. Results: Significant chondrocyte death was seen with the live-dead staining in the bupivacaine group (33% nonviable cells) in comparison with liposomal bupivacaine (6.2%) and control (5.8%) groups ( P < .01). However, histologic examination showed no differences in chondral surface integrity, fibrillation, and chondrocyte viability. Conclusion: Liposomal bupivacaine was found to be safe for intra-articular injection in this animal model. Although bupivacaine demonstrated decreased chondrocyte viability on a cellular level, histologically there were no changes. This study highlights the dichotomy between fluorescent staining and histologic appearance of articular chondrocytes in short-term analyses of viability. Clinical Relevance: This study supports the peri-articular application of liposomal bupivacaine in the setting of preserved articular cartilage. A single injection of standard bupivacaine did not produce histologic changes in the articular cartilage.
An Evaluation of Reach for a Work Site Implementation of the National Diabetes Prevention Program Focusing on Diet and Exercise
Authors: Zigmont Victoria A. , Shoben Abigail B. , Kaye Gail L. , Snow Richard J. , Clinton Steven K. , Harris Randall E. , Olivo-Marston Susan E. 
Published: October 2017

Purpose: Our objective is to evaluate the “reach” component of the Reach Effectiveness Adoption Implementation Maintenance (RE-AIM) framework by comparing prediabetics who were and were not interested in enrolling in a free work site diabetes prevention program (DPP) during the first year of the program. Reach is defined as the proportion of eligible participants who enroll in a health program. Design: A cross-sectional study design was used. Setting: The setting was a large health system in the Midwest. Participants: Prediabetic health plan enrollees and spouses (N = 2158). Measures: An online health survey, annual voluntary biometric screenings delivered by a trained health-care professional using standardized protocols via point-of-care testing, and records from the DPP office were the sources of data for this study. Analysis: Health behaviors and biometric screening results were simultaneously compared using multivariable logistic regression. Results: The study population was 63% female, 79% white, and 16% black, and the mean age was 50.2 years (SD = 10.2). The reach of this program was 10%. Prediabetics were more likely to express interest in the DPP, if they were female (adjusted odds ratio [AOR]: 2.4; 95% confidence interval [95% CI]: 1.55-3.72; P < .001), black (AOR = 2.23; 95% CI: 1.43-3.47; P < .001), older in age (AOR: 1.08; 95% CI: 0.99-1.17; P = .05), or had a high-risk waist circumference (AOR = 1.44; 95% CI: 0.98-2.13; P = .07), lower self-efficacy to make healthy changes (AOR = 0.48; 95% CI: 0.26-0.91; P = .03), and 5 or more doctor visits in the last year (AOR = 2.13; 95% CI: 0.99-4.57; P = .05), after controlling for other covariates. Conclusion: Current recruitment and implementation strategies are reaching only a small group of individuals who are not representative of the larger prediabetic population. These findings inform future engagement strategies, and we recommend that public health practitioners evaluate reach to ensure that health promotion programs are of high value.