bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Cysteinome of Protein Kinases as a Target in Drug Development
Authors: Chaikuad Apirat , Koch Pierre , Laufer Stefan A. , Knapp Stefan 
Published: October 2017

AbstractDrugs that function through covalent bond formation represent a considerable fraction of our repository of effective medicines but safety concerns and the complexity of developing covalent inhibitors has rendered covalent targeting a less attractive strategy for rational drug design. The recent approval of four covalent kinase inhibitors and the development of highly potent covalent kinase probes with exceptional selectivity has raised significant interest in industry and academic research and validated the concept of covalent kinase targeting for clinical applications. The abundance of cysteines at diverse positions in and around the kinase active site suggests that a large fraction of kinases can be targeted by covalent inhibitors. Herein, we review recent developments of this rapidly growing area in kinase drug development and highlight the unique opportunities and challenges of this strategy.
Transient Behavior of the Metal Interface in Lithium Metal–Garnet Batteries
Authors: Fu Kun (Kelvin) , Gong Yunhui , Fu Zhezhen , Xie Hua , Yao Yonggang , Liu Boyang , Carter Marcus , Wachsman Eric , Hu Liangbing 
Published: October 2017

AbstractThe interface between solid electrolytes and Li metal is a primary issue for solid‐state batteries. Introducing a metal interlayer to conformally coat solid electrolytes can improve the interface wettability of Li metal and reduce the interfacial resistance, but the mechanism of the metal interlayer is unknown. In this work, we used magnesium (Mg) as a model to investigate the effect of a metal coating on the interfacial resistance of a solid electrolyte and Li metal anode. The Li–Mg alloy has low overpotential, leading to a lower interfacial resistance. Our motivation is to understand how the metal interlayer behaves at the interface to promote increased Li‐metal wettability of the solid electrolyte surface and reduce interfacial resistance. Surprisingly, we found that the metal coating dissolved in the molten piece of Li and diffused into the bulk Li metal, leading to a small and stable interfacial resistance between the garnet solid electrolyte and the Li metal. We also found that the interfacial resistance did not change with increase in the thickness of the metal coating (5, 10, and 100 nm), due to the transient behavior of the metal interface layer.
Dimethylamine as a Substrate in Hydroaminoalkylation Reactions
Authors: Bielefeld Jens , Doye Sven 
Published: October 2017

AbstractTransition‐metal‐catalyzed hydroaminoalkylations of alkenes have made great progress over the last decade and are heading to become a viable alternative to the industrial synthesis of amines through hydroformylation of alkenes and subsequent reductive amination. In the past, one major obstacle of this progress has been an inability to apply these reactions to the most important amines, methylamine and dimethylamine. Herein, we report the first successful use of dimethylamine in catalytic hydroaminoalkylations of alkenes with good yields. We also report applicability for a variety of alkenes to show the tolerance of the reaction towards different functional groups. Additionally, we present a catalytic dihydroaminoalkylation reaction using dimethylamine, which has never been reported before.
Assembly, Thermodynamics, and Structure of a Two‐Wheeled Composite of a Dumbbell‐Shaped Molecule and Cylindrical Molecules with Different Edges
Authors: Matsuno Taisuke , Kamata Sho , Sato Sota , Yokoyama Atsutoshi , Sarkar Parantap , Isobe Hiroyuki 
Published: October 2017

AbstractA carbonaceous dumbbell was able to spontaneously glue two tubular receptors to form a unique two‐wheeled composite through van der Waals interactions, thus forcing the wheel components into contact with each other at the edges. In the present study, two tubular receptors with enantiomeric carbon networks were assembled on the dumbbell joint, and the handedness of the receptors was discriminated, thus leading to the self‐sorting of homomeric receptors from a mixture of enantiomeric tubes. The crystal structures of the composites revealed the structural origins of the molecular recognition driven by van der Waals forces as well as the presence of a columnar array of C120 molecules in a 1:1 composite.
Polyaniline‐grafted polyurethane coatings for corrosion protection of mild steel surfaces
Authors: Karmakar Himadri S. , Arukula Ravi , Thota Apparao , Narayan Ramanuj , Rao Chepuri R. K. 
Published: October 2017

ABSTRACTWe report the superior corrosion‐resistant properties of conducting polyurethane networks of polyaniline (PANI), poly‐m‐aminophenol (PmAP), and poly‐o‐anisidine (PoA) coated on mild steel panels. These networks were prepared by blending conducting polyanilines with isocyanate‐containing prepolyurethanes. Free‐standing polyurethane films were obtained after a moisture cure for several days to ensure complete reaction of the excess isocyanate. The films were electrochemically active with conductivity in the range of 10−2 to 10−3 S/cm. The solution blends and formed films were characterized by infrared, ultraviolet, thermogravimetric analysis, and differential scanning calorimetry. Electrochemical corrosion studies of the coated films on mild steel panels showed excellent corrosion protection in the following order: PU‐PANI > PU‐PmAP > PU‐PoA. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45806.
Vascularization in Ornamented Osteoderms: Physiological Implications in Ectothermy and Amphibious Lifestyle in the Crocodylomorphs?
Authors: Clarac F. , De Buffrénil V. , Cubo J. , Quilhac A. 
Published: October 2017

ABSTRACTVascularization in the core of crocodylian osteoderms, and in their superficial pits has been hypothesized to be a key feature involved in physiological thermoregulation and/or acidosis buffering during anoxia (apnea). However, up to now, there have been no quantitative data showing that the inner, or superficial, blood supply of the osteoderms is greater than that occurring in neighboring dermal tissues. We provide such data: our results clearly indicate that the vascular networks in both the osteoderms and the pits forming their superficial ornamentation are denser than in the overlying dermis. These results support previous physiological assumptions and indicate that vascularization in pseudosuchian (crocodylians and close relatives) ornamented osteoderms could be part of a broad eco‐physiological adaptation towards ectothermy and aquatic ambush predation acquired by the crocodylomorphs during their post‐Triassic evolution. Moreover, regressions demonstrate that the number of enclosed vessels is correlated with the sectional area of the cavities housing them (superficial pits and inner cavities). These regressions can be used to infer the degree of vascularization on dry and fossilized osteoderms and thus document the evolution of the putative function of the osteoderms in the Pseudosuchia. Anat Rec, 2017. © 2017 Wiley Periodicals, Inc. Anat Rec, 301:175–183, 2018. © 2017 Wiley Periodicals, Inc.
Germ Cell Migration, Proliferation and Differentiation during Gonadal Morphogenesis in All‐Female Japanese Flounder (Paralichthys Olivaceus)
Authors: Yang Yang , Liu Qinghua , Xiao Yongshuang , Wang Xueying , An Hao , Song Zongcheng , You Feng , Wang Yanfeng , Ma Daoyuan , Li Jun 
Published: October 2017

ABSTRACTIn this study, all genetic female (XX) broods of Japanese flounder were produced artificially by mating the females with sex‐reversed males. The proliferation and migration of primordial germ cells (PGCs), formation of ovary and oogenesis were described in detail. After hatching, around 20 individual PGCs migrated from the lateral to the dorsal of trunk region. At 15 days posthatching (dph), a part of PGCs were covered by a single layer somatic cells and formed the genital ridge. By 22 dph, the elongated gonadal primordia appeared under the ventral kidney, where the PGCs were totally enclosed by somatic cells. During the process of migration, PGCs were presumed to be mitotically inactive. From 63 to 73 dph, somatic cells rearrangement resulted in the formation of a narrow crevice, which became deeper and formed ovarian lumen. However, at 52 dph, dramatic mitotic proliferation of germ cell occurred and germline nest formed before the appearance of ovarian lumen. The onset of intensive germ cell proliferation and appearance of cell nests could be accepted as a criterion of initial ovarian differentiation. Then germ cells and somatic epithelial cells were gradually delimited by basement membrane and formed the germinal epithelium. In this period, results from in situ hybridization revealed that the early forkhead box L2 (pofoxl2) was expressed in somatic cells and oocytes in primary growth, which indicated the prefollicle cells formed. Then oogonia or oocytes, follicle cells, basement membrane, and theca cells composed a follicle complex. Finally, oocytes underwent meiosis and developed into to mature eggs. Anat Rec, 301:727–741, 2018. © 2017 Wiley Periodicals, Inc.
The Cytoarchitecture of the Telencephalon of Betta Splendens Regan 1910 (Perciformes: Anabantoidei) with a Stereological Approach to the Supracommissural and Postcommissural Nuclei
Authors: Magalhães Horn Ângelo Cássio , Rasia‐Filho Alberto A. 
Published: October 2017

ABSTRACTTeleostean fish brains are useful models to study cellular and functional specializations along the phylogenesis. The Betta splendens Regan 1910 (Siamese fighting fish; Perciformes:Anabantoidei) is known for its aggressive display, courtship behavior, nest building, and offspring care. Here, we present novel and detailed data about the cytoarchitecture of the olfactory bulb and the telencephalic hemispheres of this fish. The hematoxylin‐eosin and Nissl techniques served to identify brain nuclei (n = 19 males and n = 21 females) and for the stereological evaluation of the numerical density of cells and the proportion of neurons and glial cells in the ventral telencephalon supracommissural (Vs) and postcommissural (Vp) nuclei of adult males and females. These nuclei are putative homologs of the sexually dimorphic medial amygdala in mammals. The olfactory bulb of Betta splendens consists of 5 concentrically arranged layers plus ganglion cells of the terminal nerves. The dorsal telencephalon consists of 16 different cell groups. The ventral telencephalon has 8 nuclei, plus the lateral septal organ and the nuclei of the preoptic area forming an anatomical continuum. The rostrocaudal extent of the Vs and Vp is not different between sexes. In both nuclei, the proportion of neurons to glial cells is approximately 2:1 and the density of neurons and glial cells is not different between sexes. These morphological findings can subserve future research on the brain function of the Betta splendens and the search for neural sex differences in other central areas of this same species, in other teleost species, or yet in other related vertebrate group. Anat Rec, 00:000–000, 2017. © 2017 Wiley Periodicals, Inc. Anat Rec, 301:88–110, 2018. © 2017 Wiley Periodicals, Inc.
Identifying patterns of adaptation in breast cancer patients with cancer‐related fatigue using response shift analyses at subgroup level
Authors: Salmon Maxime , Blanchin Myriam , Rotonda Christine , Guillemin Francis , Sébille Véronique 
Published: October 2017

AbstractFatigue is the most prevalent symptom in breast cancer. It might be perceived differently among patients over time as a consequence of the differing patients’ adaptation and psychological adjustment to their cancer experience which can be related to response shift (RS). RS analyses can provide important insights on patients’ adaptation to cancer but it is usually assumed that RS occurs in the same way in all individuals which is unrealistic. This study aimed to identify patients’ subgroups in which different RS effects on self‐reported fatigue could occur over time using a combination of methods for manifest and latent variables. The FATSEIN study comprised 466 breast cancer patients followed over a 2‐year period. Fatigue was measured with the Multidimensional Fatigue Inventory questionnaire (MFI‐20) during 10 visits. A novel combination of Mixed Models, Growth Mixture Modeling, and Structural Equation Modeling was used to assess the occurrence of RS in fatigue changes to identify subgroups displaying different RS patterns over time. An increase in fatigue was evidenced over the 8‐month follow‐up, followed by a decrease between the 8‐ and 24‐month. Four latent classes of patients were identified. Different RS patterns were detected in all latent classes between the inclusion and 8 months (last cycle of chemotherapy). No RS was evidenced between 8‐ and 24‐month. Several RS effects were evidenced in different groups of patients. Women seemed to adapt differently to their treatment and breast cancer experience possibly indicating differing needs for medical/psychological support.
High magnesium prevents matrix vesicle‐mediated mineralization in human bone marrow‐derived mesenchymal stem cells via mitochondrial pathway and autophagy
Authors: Li Yaqiang , Wang Jing , Yue Jiaji , Wang Yu , Yang Chunxi , Cui Quanjun 
Published: October 2017

AbstractMagnesium, as a physiological calcium antagonist, plays a vital role in the bone metabolism and the balance between magnesium and calcium is crucial in bone physiology. We recently demonstrated that matrix mineralization in human bone marrow‐derived mesenchymal stem cells (hBMSCs) can be suppressed by high Mg2+. However, a complete understanding of the mechanisms involved still remains to be elucidated. As mitochondrial calcium phosphate granules depletion manifests concurrently with the appearance of matrix vesicles (MVs) and autophagy are associated with matrix mineralization, we studied the effect of high extracellular Mg2+ on these pathways. Our results first demonstrated that high Mg2+ has a significant inhibitory effect on the generalization of extracellular mineral aggregates and the expression of collagen 1 along which the mineral crystals grow. Transmission electron microscope results showed that less amount of MVs were observed inside hBMSCs treated with high Mg2+ and high Mg2+ inhibited the release of MVs. In addition, high Mg2+ significantly suppressed mitochondrial Ca2+ accumulation. Autophagy is promoted as a response to osteogenesis of hBMSCs. High Mg2+ inhibited the level of autophagy upon osteogenesis and autophagy inhibitor 3‐MA significantly suppressed mineralization. Exogenous ATP can reverse the inhibitory effect of high Mg2+ by increasing the level of autophagy. Taken together, our results indicate that high Mg2+ may modulate MVs‐mediated mineralization via suppressing mitochondrial Ca2+ intensity and regulates autophagy of hBMSCs upon osteogenesis, resulting in decreased extracellular mineralized matrix deposition. Our results contribute to the understanding of the role of magnesium homeostasis in osteoporosis and the design of magnesium alloys.
Efficacy of alprostadil in preventing contrast‐induced nephropathy in patients undergoing percutaneous coronary intervention: A multicenter prospective randomized controlled trial
Authors: Liang Min , Yang Shicheng , Fu Naikuan , Lu Chengzhi , Tian Fengshi , Xing Xiaochun , Lin Wenhua , Liu Jingjing 
Published: October 2017

AbstractBackgroundThe role of alprostadil on the prevention of contrast‐induced nephropathy (CIN) still remains controversial. The purpose of this study was to examine the effects of short‐term alprostadil on the incidence of CIN in patients undergoing elective percutaneous coronary intervention (PCI).MethodsA total of 480 patients with coronary heart disease undergoing PCI were enrolled in our study and randomly assigned to two groups. The control group (n = 240) was given only hydration therapy and the alprostadil group (n = 240) received intravenous administration of 20 ug/day (diluted with 100 ml normal saline) from 0.5∼1 hr before to 3 days after operation on the basis of hydration. The primary endpoint of the study was the incidence of CIN, which was defined as an increase in SCr concentration ≥ 44.2 umol/l or ≥25% above baseline within 48 hr∼72 hr after exposure of contrast media.ResultsThe incidence of CIN was significantly lower in the alprostadil group than that in the control group (6.25% vs 11.67%,P = 0.038). Multivariate logistic regression analysis showed that alprostadil was the protective factor of CIN (OR = 0.699, 95% CI 0.542–0.902,P = 0.006). The benefits against CIN were consistent in prespecified high‐risk patients with diabetes mellitus (P = 0.003). In addition, we also found that hs‐CRP and blood homocysteine values after PCI were significantly lower in the alprostadil group than those in the control group.ConclusionProphylactic administration of alprostadil may prevent against CIN in coronary heart disease patients undergoing elective PCI, particularly in high‐risk patients with diabetes mellitus.
Second‐generation drug‐eluting stents versus drug‐coated balloons for the treatment of coronary in‐stent restenosis: A systematic review and meta‐analysis
Authors: Kokkinidis Damianos G. , Prouse Andrew F. , Avner Seth J. , Lee Joo Myung , Waldo Stephen W. , Armstrong Ehrin J. 
Published: October 2017

AbstractPurposeThe benefit of drug‐eluting stents (DES) versus drug‐coated balloons (DCB) in coronary artery in‐stent restenosis (ISR) for the prevention of target lesion revascularization (TLR), stent thrombosis, and mortality remains uncertain. Our aim was to synthesize the available evidence from randomized clinical trials (RCTs) and observational studies that directly compare second‐generation drug‐eluting stents (SG‐DES) and DCB for the treatment of coronary ISR.MethodsMedline, Embase, and Cochrane Central were searched for RCTs or observational studies, published up to March 15, 2017. A random effects model meta‐analysis investigating clinical and angiographic outcomes was conducted for RCTs and observational studies that compared SG‐DES versus DCB for the treatment of ISR.ResultsTen studies and 2,173 patients were included in this meta‐analysis. The two treatment strategies were proven equal with regards to TLR, myocardial infarction, stent thrombosis, and cardiac mortality in both randomized and observational studies. No difference was found among RCTs for all‐cause mortality, while in observational studies, patients who were treated with SG‐DES had a lower mortality compared to DCB (OR: 0.47; 95% CI: 0.27–0.83). In the pooled analysis also (RCTs and observational studies), SG‐DES were associated with lower all‐cause mortality compared to DCB. Patients treated with SG‐DES were also superior in terms of minimal lumen diameter (standardized mean difference: 0.39; 95% CI: 0.12–0.66).ConclusionsThe two treatment strategies are equal for the treatment of ISR, while the difference in all‐cause mortality might be potentially explained by baseline differences in the two groups among real‐world studies.
Comparison of outcomes with surgical cut‐down versus percutaneous transfemoral transcatheter aortic valve replacement: TAVR transfemoral access comparisons between surgical cut‐down and percutaneous approach
Authors: Drafts Brandon C. , Choi Charles H. , Sangal Kunal , Cammarata Michael W. , Applegate Robert J. , Gandhi Sanjay K. , Kincaid Edward H. , Kon Neal , Zhao David X. 
Published: October 2017

AbstractObjectivesThe objective is to compare the short‐term (30 days) and late (12 months) vascular adverse events in patients undergoing transfemoral (TF)‐transcatheter aortic valve replacement (TAVR) by surgical cut‐down (SC) vs. percutaneous (PC) approaches.BackgroundPrograms continue to utilize both approaches in TF‐TAVR. There are limited data comparing outcomes by SC vs. PC approaches and long‐term effects of endovascular intervention facilitated hemostasis on late vascular adverse events.MethodsA total of 146 men and women aged 79.7 ± 10.0 years with severe aortic stenosis deemed extreme or high risk for surgery underwent TAVR via TF access. 61 had SC and 85 had PC approaches. Valve Academic Research Consortium (VARC‐2) outcomes were assessed at an average of 12.1 months after TAVR.ResultsHospital length of stay (LOS) post‐TAVR was shorter for the PC group compared to the SC group (5.1 ± 3.9 vs. 8.2 ± 6.6 days; P < 0.001). More patients were discharged directly to home in the PC than the SC group (85.9% vs. 68.9%, P < 0.05). At 30 days, there were 13/61 (21.3%) and 16/85 (18.8%; P < 0.05) of any vascular events, and 2/61 (3.3%) and 2/85 (2.4%; P = 0.73) major vascular events in the SC and PC groups, respectively. There was no difference in all‐cause mortality between the SC (14/61; 23%) and PC groups [17/85 (20%); P = 0.34]. There was no difference in any [4/33 (12%) vs. 3/43 (7%); P = 0.84] or major vascular adverse events [1/33 (3%) vs. 1/43 (2%); P = 0.79] in subjects that underwent adjunctive endovascular intervention compared to those who did not, respectively. There were no statistically significant univariate or multivariate predictors of any vascular event at 12 months when comparing SC to PC groups.ConclusionFor TF TAVR, the PC approach, when compared to the SC approach, is associated with a shorter hospital LOS and higher rate of direct discharge to home with similar risk of vascular complications, late vascular adverse events, and all‐cause mortality at 12 months.
Gemcitabine and carfilzomib induced thrombotic microangiopathy: eculizumab as a life‐saving treatment
Authors: Gosain Rahul , Gill Amitoj , Fuqua Jacob , Volz Lesley H. , Kessans Knable Mika R. , Bycroft Ryan , Seger Sarah , Gosain Rohit , Rios Jorge A. , Chao Ju‐Hsien 
Published: October 2017

Key Clinical MessageDrug‐induced aHUS is rare; however, early diagnosis is vital to reduce morbidity and mortality. With confirmation of the diagnosis, eculizumab appears to be a viable treatment option to suppress the pro‐inflammatory surge. Furthermore, adverse side effects of medications such as carfilzomib and gemcitabine should be considered in the appropriate settings.
Hydrogenation of Lactic Acid to 1,2‐Propanediol over Ru‐Based Catalysts
Authors: Liu Kaituo , Huang Xiaoming , Pidko Evgeny A. , Hensen Emiel J. M. 
Published: October 2017

AbstractThe catalytic hydrogenation of lactic acid to 1,2‐propanediol with supported Ru catalysts in water was investigated. The influence of catalyst support (activated carbon, γ‐Al2O3, SiO2, TiO2, and CeO2) and promoters (Pd, Au, Mo, Re, Sn) on the catalytic performance was evaluated. Catalytic tests revealed that TiO2 yields the best Ru catalysts. With a monometallic Ru/TiO2 catalyst, a 1,2‐propanediol yield of 70 % at 79 % lactic acid conversion was achieved at 130 °C after 20 h reaction. Minor byproducts of the hydrogenation reaction were propionic acid, ethanol, 1‐propanol, and 2‐propanol. For the bimetallic catalysts, the addition of Pd and Au slightly enhanced the performance of Ru/TiO2, whereas the addition of common hydrogenation promoters such as Re, Mo, and Sn impaired the activity.
Versatile Heterogeneous Palladium Catalysts for Diverse Carbonylation Reactions under Atmospheric Carbon Monoxide Pressure
Authors: Vico Solano Marta , González Miera Greco , Pascanu Vlad , Inge A. Ken , Martín‐Matute Belén 
Published: October 2017

AbstractHerein, we report a versatile carbonylation protocol using heterogeneous Pd0 nanoparticles supported on the metal–organic frameworks (MOFs) MIL‐88B‐NH2 (Fe/Cr). The synthesis of a vast array of carbonyls, which includes amides, esters, carboxylic acids, and α‐ketoamides, was achieved through mono‐ and dicarbonylation reactions. The selectivity could be controlled simply by tuning the reaction conditions. Superior activity and selectivity were recorded in some cases compared to that achieved with commercial Pd/C. However, the utility of an elaborate catalyst support is questionable and important reactivity and recyclability issues are discussed.