bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Recovery of Left Ventricular Systolic Function After CoreValve Transcatheter Aortic Valve Replacement
Authors: Dauerman Harold L. , Reardon Michael J. , Popma Jeffrey J. , Little Stephen H. , Cavalcante João L. , Adams David H. , Kleiman Neil S. , Oh Jae K. 
Published: June 2016

Background—
Approximately one third of patients with symptomatic aortic stenosis have reduced left ventricular ejection fraction (LVEF) before transcatheter aortic valve replacement. The incidence, predictors, and significance of early LVEF recovery after CoreValve transcatheter aortic valve replacement have not been described.

Methods and Results—

We studied 156 patients from the CoreValve Extreme and High-Risk trials with LVEF ≤40% at baseline who had 30-day LVEF data. All patients underwent core laboratory echocardiographic assessment of LVEF at baseline, post procedure, discharge, 30 days, 6 months, and 1 year. Early LVEF recovery was defined as an absolute increase of ≥10% in EF at 30 days. One-year outcomes were compared between patients with and without early recovery. Multivariable analysis was performed to determine independent predictors of early recovery. Early LVEF recovery occurred in 62% of patients, generally before discharge. By 30 days LVEF increased >17% compared with baseline in the early recovery group with minimal increase in the no–early recovery group (48.9±8.8% versus 31.5±6.9%;
P
<0.001). One-year all-cause mortality was numerically (but not statistically) higher in the no–early recovery group (24% versus 12%;
P
=0.07). Absence of previous myocardial infarction (odds ratio, 0.44; 95% confidence interval, 0.19–1.03) and baseline mean gradient ≥40 mm Hg (odds ratio, 4.59; 95% confidence interval, 1.76–11.96) were identified as predictors of early LVEF recovery.

Conclusions—
Nearly two thirds of patients with reduced LVEF will have a marked early improvement after transcatheter aortic valve replacement. Early LVEF recovery is associated with improved clinical outcomes and is most likely among patients with higher baseline aortic valve gradients and no previous myocardial infarction.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01240902.
Leisure Time Physical Activity and Cardio‐Metabolic Health: Results From the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil)
Authors: Lin Xiaochen , Alvim Sheila M. , Simoes Eduardo J. , Bensenor Isabela M. , Barreto Sandhi M. , Schmidt Maria I. , Ribeiro Antonio L. , Pitanga Francisco , Almeida Maria Conceição C. , Liu Simin , Lotufo Paulo A. 
Published: June 2016

Background
Although increasing effort has been devoted to the promotion of a healthy lifestyle such as leisure time physical activity for cardio‐metabolic health, specific evidence supporting health policy remains sparse, particularly in those ethnically diverse populations where cardio‐metabolic diseases are reaching epidemic proportion and yet are grossly understudied.

Methods and Results

We conducted a cross‐sectional analysis of the baseline data from 10 585 participants aged 35 to 74 free of cardiovascular diseases in the Brazilian Longitudinal Study of Adult Health. Leisure time physical activity status was defined by the American Heart Association and the World Health Organization recommendations (≥150 min/week moderate activities or 75 min/week vigorous activities). In total, 1183 (21%) women and 1387 (29%) men were active. After accounting for covariates, the favorable effects of leisure time physical activity on cardio‐metabolic parameters were evident. Specifically, the average blood pressure, heart rate, and Framingham Risk Score for cardiovascular diseases of the active were significantly lower within each sex. The
OR
s comparing the active versus the inactive women were 0.78 (95%
CI
: 0.66–0.92) for hypertension and 0.78 (95%
CI
: 0.65–0.93) for cardiovascular diseases in 10 years. Among men, the
OR
s were 0.75 (95%
CI
: 0.65–0.87) for hypertension and 0.73 (95%
CI
: 0.61–0.87) for diabetes. The 10‐year risk of cardiovascular diseases was significantly lower among the active men with a 33% reduction (
OR
=0.67, 95%
CI
: 0.57–0.78).

Conclusions
We observed beneficial effects of leisure time physical activity on cardio‐metabolic health in this large Brazilian population that are consistent with studies in North America and Europe.
Zingiber skornickovae, a new species of Zingiberaceae from Central Vietnam
Authors: LÝ NGỌC-SÂM 
Published: June 2016

Zingiber skornickovae, a new species from central Vietnam, is described and illustrated. A comparison with the two most closely related species of Zingiber sect. Cryptanthium, Z. thorelii and Z. recurvatum, and a key to all procumbent flowering species in Vietnam are provided.
Impact of Satellite Data Assimilation in Atmospheric Reanalysis on the Marine Wind and Wave Climate
Authors: Sasaki Wataru 
Published: June 2016

Abstract
This study investigated the impact of assimilating satellite data into atmospheric reanalyses on trends in ocean surface winds and waves. Two experiments were performed using a numerical wave model forced by near-surface winds: one derived from the Japanese 55-year Reanalysis (JRA-55; experiment A) and the other derived from JRA-55 using assimilated conventional observations only (JRA-55C; experiment B). The results showed that the satellite data assimilation reduced upward trends of the annual mean of wave energy flux (WEF) in the midlatitude North Pacific and southern ocean (30°–60°S), south of Australia, from 1959 to 2012. It was also found that the assimilation of scatterometer winds reduced the near-surface wind speed in the midlatitude North Pacific after the mid-1990s, which resulted in the reduced trend in WEF from 1959 to 2012. By contrast, assimilation of the satellite radiances for 1973–94 increased near-surface wind speed in the southern ocean, south of Australia, whereas the assimilation of the scatterometer winds after the mid-1990s reduced wind speed. The latter led to the reduced trend in WEF south of Australia from 1959 to 2012.
A Simple Model for Sheddies: Ocean Eddies Formed from Shed Vorticity
Authors: Southwick O. R. , Johnson E. R. , McDonald N. R. 
Published: June 2016

AbstractRecent studies show that vertical eddy diffusivity is sufficient on its own to introduce intense horizontal shear layers at sloping ocean margins (Molemaker et al.; Gula et al.; Dewar et al.). These layers influence mesoscale energy and potential vorticity budgets but cannot be fully represented in models without sloping boundaries, no-slip boundary conditions, and sufficiently high resolution. This paper investigates the detachment of these shear layers and their subsequent rolling up into concentrated eddies. These shed eddies, or “sheddies,” may have significant oceanographic impacts. Their growth is considered using a simple point vortex model that adapts the Brown–Michael model of vortex shedding to quasigeostrophic flow and allows detailed consideration of the vorticity fluxes. The model shows good qualitative agreement with observations and experimental and numerical results. It is applied to a number of examples of well-known cases of sheddy formation, including the Agulhas cyclones, California Undercurrent, and Canary Eddy Corridor, and also is used to investigate the effects of shed vorticity in the growth of the Cook Strait eddy and the interaction of the North Brazil Current rings with the islands of the Lesser Antilles.
Intercomparison of Unmanned Aircraftborne and Mobile Mesonet Atmospheric Sensors
Authors: Houston Adam L. , Laurence Roger J. , Nichols Tevis W. , Waugh Sean , Argrow Brian , Ziegler Conrad L. 
Published: June 2016

AbstractResults are presented from an intercomparison of temperature, humidity, and wind velocity sensors of the Tempest unmanned aircraft system (UAS) and the National Severe Storms Laboratory (NSSL) mobile mesonet (NSSL-MM). Contemporaneous evaluation of sensor performance was facilitated by mounting the Tempest wing with attached sensors to the NSSL-MM instrument rack such that the Tempest and NSSL-MM sensors could collect observations within a nearly identical airstream. This intercomparison was complemented by wind tunnel simulations designed to evaluate the impact of the mobile mesonet vehicle on the observed wind velocity.The intercomparison revealed strong correspondence between the temperature and relative humidity (RH) data collected by the Tempest and the NSSL-MM with differences generally within sensor accuracies. Larger RH differences were noted in the presence of heavy precipitation; however, despite the exposure of the Tempest temperature and humidity sensor to the airstream, there was no evidence of wet bulbing within precipitation. Wind tunnel simulations revealed that the simulated winds at the location of the NSSL-MM wind monitor were ~4% larger than the expected winds due to the acceleration of the flow over the vehicle. Simulated vertical velocity exceeded 1 m s−1 for tunnel inlet speeds typical of a vehicle moving at highway speeds. However, the theoretical noncosine reduction in winds that should result from the impact of vertical velocity on the laterally mounted wind monitor was found to be negligible across the simulations. Comparison of the simulated and observed results indicates a close correspondence, provided the crosswind component of the flow is small.
A Case Study on the Far-Field Properties of Propagating Tropospheric Gravity Waves
Authors: Stephan Claudia C. , Alexander M. Joan , Hedlin Michael , de Groot-Hedlin Catherine D. , Hoffmann Lars 
Published: June 2016

Abstract
Mesoscale gravity waves were observed by barometers deployed as part of the USArray Transportable Array on 29 June 2011 near two mesoscale convective systems in the Great Plains region of the United States. Simultaneously, AIRS satellite data indicated stratospheric gravity waves propagating away from the location of active convection. Peak perturbation pressure values associated with waves propagating outside of regions where there was precipitation reached amplitudes close to 400 Pa at the surface. Here the origins of the waves and their relationship to observed precipitation are investigated with a specialized model study. Simulations with a 4-km resolution dry numerical model reproduce the propagation characteristics and amplitudes of the observed waves with a high degree of quantitative similarity despite the absence of any boundary layer processes, surface topography, or moist physics in the model. The model is forced with a three-dimensional, time-dependent latent heating/cooling field that mimics the latent heating inside the precipitation systems. The heating is derived from the network of weather radar precipitation observations. This shows that deep, intense latent heat release within the precipitation systems is the key forcing mechanism for the waves observed at ground level by the USArray. Furthermore, the model simulations allow for a more detailed investigation of the vertical structure and propagation characteristics of the waves. It is found that the stratospheric and tropospheric waves are triggered by the same sources, but have different spectral properties. Results also suggest that the propagating tropospheric waves may potentially remotely interact with and enhance active precipitation.
Observing Boundary-Layer Winds from Hot-Air Balloon Flights
Authors: de Bruijn Evert I. F. , de Haan Siebren , Bosveld Fred C. , Schreur Ben Wichers , Holtslag Albert A. M. 
Published: June 2016

Abstract
High-resolution upper-air wind observations are sparse, and additional observations are a welcome source of meteorological information. In this paper the potential of applying balloon flights for upper-air wind measurements is explored, and the meteorological content of this information is investigated. The displacement of a hot-air balloon is a measure for the wind speed and direction and thus a potential source for wind observations in the lower part of the troposphere. The response time of the balloon on the changing wind is fast in the beginning and levels off for smaller relative wind speeds. Four case studies are presented, and the balloon-derived winds are compared with other wind observations and with results from the HIRLAM–ALADIN Research on Mesoscale Operational NWP in Europe (HARMONIE) model. It turns out that hot-air balloon tracks can indeed produce useful wind observations just above and in the atmospheric boundary layer (ABL).
EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma
Authors: Yan Junli , Li Boheng , Lin Baohong , Lee Pei Tsung , Chung Tae-Hoon , Tan Joy , Bi Chonglei , Lee Xue Ting , Selvarajan Viknesvaran , Ng Siok-Bian , Yang Henry , Yu Qiang , Chng Wee-Joo 
Published: June 2016

Key Points
JAK3-mediated phosphorylation of EZH2 resulted in EZH2 oncogenic function independent of its enzymatic activity. Targeted inhibition of JAK3 may be a promising treatment in NK/TL through suppressing noncanonical EZH2 activity.
FcγRIIB on liver sinusoidal endothelial cells is essential for antibody-induced GPVI ectodomain shedding in mice
Authors: Stegner David , Popp Michael , Lorenz Viola , Wax Jacqueline K. , Gessner J. Engelbert , Nieswandt Bernhard 
Published: June 2016

Key Points
Antibody-induced shedding of platelet GPVI in vivo and the associated transient thrombocytopenia depend on liver sinusoidal endothelial cell-expressed FcγRIIB.
Recent global trends in the prevalence and incidence of dementia, and survival with dementia
Authors: Prince Martin , Ali Gemma-Claire , Guerchet Maëlenn , Prina A. Matthew , Albanese Emiliano , Wu Yu-Tzu 
Published: June 2016

Abstract
Background
Current projections of the scale of the coming dementia epidemic assume that the age- and sex-specific prevalence of dementia will not vary over time, and that population ageing alone (increasing the number of older people at risk) drives the projected increases. The basis for this assumption is doubtful, and secular trends (that is, gradual decreases or increases in prevalence over long-term periods) are perfectly plausible.

Methods
We carried out a systematic review of studies of trends in prevalence, incidence and mortality for people with dementia, conducted since 1980.

Results
We identified nine studies that had tracked dementia prevalence, eight that had tracked dementia incidence, and four that had tracked mortality among people with dementia. There was some moderately consistent evidence to suggest that the incidence of dementia may be declining in high-income countries. Evidence on trends in the prevalence of dementia were inconsistent across studies and did not suggest any clear overall effect. Declining incidence may be balanced by longer survival with dementia, although mortality trends have been little studied. There is some evidence to suggest increasing prevalence in East Asia, consistent with worsening cardiovascular risk factor profiles, although secular changes in diagnostic criteria may also have contributed.

Conclusions
We found no evidence to suggest that the current assumption of constant age-specific prevalence of dementia over time is ill-founded. However, there remains some uncertainty as to the future scale of the dementia epidemic. Population ageing seems destined to play the greatest role, and prudent policymakers should plan future service provision based upon current prevalence projections. Additional priorities should include investing in brain health promotion and dementia prevention programs, and monitoring the future course of the epidemic to chart the effectiveness of these measures.
Vestibular function following unilateral cochlear implantation for profound sensorineural hearing loss
Authors: le Nobel Gavin J. , Hwang Euna , Wu Adrian , Cushing Sharon , Lin Vincent Y. 
Published: June 2016

Background Many Canadians are affected by sensorineural hearing loss (SNHL) and those with severe or profound hearing loss may have poor hearing function despite optimized hearing aids. Cochlear implants (CI) offer effective hearing rehabilitation for these patients, however, concern continues to exist regarding possible effects of CI on the vestibular system and balance. The objective of this study was to conduct a pilot study assessing the effects of unilateral cochlear implantation (CI) on balance and the vestibular system in post-lingually deafened adults. Methods Twelve patients were included in this pilot study and were assessed pre-operatively and at immediate, 1 week, and 1 month post-operative intervals. Assessments consisted of the dizziness handicap inventory (DHI), subjective visual vertical (SVV), and timed up-and-go testing (TUG). When applicable, testing was repeated with the CI on and off. Results Many patients were found to have deviated SVV at pre-operative and post-operative assessments. However, statistically significant changes were not seen when comparing pre-operative and post-operative SVV or when comparing SVV with the CI on and with the CI off. DHI was found to improve in five patients and worsen in two patients, however, no statistically significant change was found in DHI scores or with TUG testing. Conclusions This current pilot study does not indicate that CI surgery or implant activity influence vestibular or balance function, however, this pilot study is underpowered and greater numbers of patients would need be assessed to confirm these findings.
Randomized, Double-Blind, Placebo-Controlled Phase III Study of Tasquinimod in Men With Metastatic Castration-Resistant Prostate Cancer
Authors: Sternberg Cora , Armstrong Andrew , Pili Roberto , Ng Siobhan , Huddart Robert , Agarwal Neeraj , Khvorostenko Denis , Lyulko Olexiy , Brize Arija , Vogelzang Nicholas , Delva Rémy , Harza Mihai , Thanos Anastasios , James Nicholas , Werbrouck Patrick , Bögemann Martin , Hutson Thomas , Milecki Piotr , Chowdhury Simon , Gallardo Enrique , Schwartsmann Gilberto , Pouget Jean-Christophe , Baton Frédérique , Nederman Thore , Tuvesson Helen , Carducci Michael 
Published: June 2016

Purpose Tasquinimod, a novel oral therapy targeting the tumor microenvironment, significantly improved progression-free survival (PFS) in a randomized, placebo-controlled phase II trial in men with metastatic castration-resistant prostate cancer (mCRPC). This phase III study was conducted to confirm the phase II results and to detect an overall survival (OS) benefit. Patients and Methods Men with chemotherapy-naïve mCRPC and evidence of bone metastases were assigned (2:1) to receive tasquinimod once per day or placebo until progression or toxicity. The primary end point was radiographic PFS (rPFS; time from random assignment to radiologic progression or death) per Prostate Cancer Working Group 2 criteria and RECIST 1.1. The study had 99.9% power to detect an rPFS hazard ratio (HR) of 0.6 with a two-sided alpha error of .05 and 80% power to detect a target HR of 0.8 for OS, the key secondary end point. Results In all, 1,245 patients were randomly assigned to either tasquinimod (n = 832) or placebo (n = 413) between March 2011 and December 2012 at 241 sites in 37 countries. Baseline characteristics were balanced between groups: median age, 71 years; Karnofsky performance status ≥ 90%, 77.3%; and visceral metastases, 21.1%. Estimated median rPFS by central review was 7.0 months (95% CI, 5.8 to 8.2 months) with tasquinimod and 4.4 months (95% CI, 3.5 to 5.5 months) with placebo (HR, 0.64; 95% CI, 0.54 to 0.75; P < .001). Median OS was 21.3 months (95% CI, 19.5 to 23.0 months) with tasquinimod and 24.0 months (95% CI, 21.4 to 26.9 months) with placebo (HR, 1.10; 95% CI, 0.94 to 1.28; P = .25). Grade ≥ 3 adverse events were more frequent with tasquinimod (42.8% v 33.6%), the most common being anemia, fatigue, and cancer pain. Conclusion In chemotherapy-naïve men with mCRPC, tasquinimod significantly improved rPFS compared with placebo. However, no OS benefit was observed.
Management of Brain Metastases in ALK-Positive Non–Small-Cell Lung Cancer
Authors: Rusthoven Chad G. , Doebele Robert C. 
Published: June 2016

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. A 54-year-old man with a former 15-pack-year smoking history presents with cough and dyspnea. Initial work-up with imaging demonstrates a right suprahilar mass measuring 4.7 cm as well as several enlarged hilar and ipsilateral mediastinal lymph nodes. Bronchoscopy with biopsy reveals adenocarcinoma consistent with a lung primary. Staging with positron emission tomography/computed tomography (PET/CT) reidentifies the primary mass and lymph nodes and shows several PET-avid bone metastases. Brain magnetic resonance imaging (MRI) demonstrates a 1.6-cm right parietal mass with mild vasogenic edema and four additional brain metastases measuring 4 to 9 mm in size. Molecular testing is positive for an anaplastic lymphoma kinase (ALK) gene rearrangement using fluorescence in situ hybridization and negative for EGFR, ROS1, RET, BRAF, KRAS, and other oncogenes. The patient denies any neurologic symptoms and has no significant findings on neurologic exam. He is referred to you for management options for newly diagnosed stage IV (T2aN2M1b) lung adenocarcinoma.
Perylene Bisimide-Based Donor–Acceptor Materials Incorporating Oligothiophenes: Synthesis, Characterization, Thin-Film Properties, and Nanomorphology
Authors: Nakabayashi Kazuhiro , Takeuchi Yuhei , Mori Hideharu 
Published: June 2016

Abstract
We developed a series of perylene bisimide (PBI)-based small molecules with donor–acceptor (D–A) architecture (PBI1, PBI2, and PBI3). By tuning the D–A architecture, intramolecular charge transfer (ICT) could be controlled; as a result, optical band gaps and HOMO levels of PBI1–3 were widely tunable from 1.83 to 1.44 eV and from −5.85 to −5.55 eV, respectively. Furthermore, extremely wide light absorption over 900 nm was observed in the thermal annealed PBI1–3 blend film. The grazing incidence wide angle X-ray scattering (GIWAXS) analysis demonstrated that the as-spun PBI2 thin film had the highest ordered nanostructure among PBI1–3, in which diffraction corresponding to π–π stacking was clearly observed in isotropic orientations.
De desempregado a empresário: uma ameaça ou a oportunidade que faltava?
Authors: Pech Gerson 
Published: June 2016

Demitido da empresa em que trabalhava, Marcos Mesquita precisa tomar uma decisão em relação ao investimento que realizará com a sua rescisão. Ele estuda a possibilidade de abrir uma franquia, entretanto não está bem certo sobre se esse é mesmo o melhor a fazer. O caso pode ser usado em cursos e disciplinas cujos objetivos estejam voltados à análise dos riscos envolvidos em uma decisão de investimentos em novos negócios.
Midas CS: os desafios para implantação de um RH estratégico
Authors: Higa Valter Genchin 
Published: June 2016

Amanda Amara acaba de assumir a diretoria de RH da Midas CS, empresa que possui de uma das maiores redes de franquias no setor varejista de alimentos no Brasil. Para o fundador e presidente da empresa, uma das grandes fraquezas da empresa é a alta rotatividade de franqueados, que necessitam de maior treinamento. A nova executiva, no entanto, acredita que é preciso ir além. O caso foi elaborado para ser aplicado em cursos de pós-graduação em Administração de Empresas que abordem temas relacionados a recursos humanos, cultura organizacional, liderança e gestão estratégica.