bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adolescent escitalopram prevents the effects of maternal separation on depression‐ and anxiety‐like behaviours and regulates the levels of inflammatory cytokines in adult male mice
Authors: Wang Qi , Dong Xiaomei , Wang Yan , Liu Mengxi , Sun Anji , Li Nannan , lin Yiwei , Geng Zhongli , Jin Ye , Li Xiaobai 
Published: August 2017

AbstractThere is little research on the effects of adolescent administration of antidepressants on behavioural function and inflammation in early‐life stressed adult mice. Using maternal separation (MS), a paradigm of early adversity, we investigated the effects of adolescent (PND 33‐54) escitalopram (ES; 10 mg/kg) exposure on depression‐ and anxiety‐like behaviours and the levels of inflammatory cytokines (interleukin [IL]‐1β, tumor necrosis factor [TNF]‐α, and IL‐10) in the ventral hippocampus (HPV), prefrontal cortex (PFC), and serum in adult (PND 61) male offspring mice. The results showed that MS has no effect on locomotor activity, but increased depression‐like behaviours in the saccharin preference test and increased anxiety‐like behaviours in the social preference and elevated plus maze tests. MS increased the levels of IL‐1β in the HPV, PFC, and serum, while decreasing the level of IL‐10 in the HPV. Furthermore, adolescent ES treatment inhibited these depression‐ and anxiety‐like behaviours, decreased the levels of IL‐1β, and increased the level of IL‐10 in the HPV. The results also showed that there are no effects of chronic escitalopram administration on normal behaviour in control mice. Taken together, the current data provide experimental evidence that MS increases depression and anxiety levels in adult male offspring. Additionally, the findings support the idea that early pharmacological intervention with ES may be an effective treatment for reducing the behavioral abnormalities induced by early adversity and regulating the underlying inflammatory mechanisms involved.
On the Division of Moral Labour for Human Rights Between States and Corporations: A Reply to Hsieh
Authors: ARNOLD Denis G. 
Published: August 2017

AbstractIn a series of previous articles I have defended the claim that there are robust, theoretical justifications for concluding that corporations have human rights obligations and that those obligations are distinct from the larger set of human rights obligations that are properly attributed to states. Hsieh claims that corporations do not have human rights obligations. In this reply it is argued that even if one takes what Hsieh refers to as an ‘institutional approach’ to understanding the human rights obligations of states, corporations are nonetheless properly understood to have human rights obligations regarding those with whom they interact, such as workers, customers and community members.
Quantifying Network Dynamics and Information Flow Across Chinese Social Media During the African Ebola Outbreak
Authors: Feng Shihui , Hossain Liaquat , Crawford John W. , Bossomaier Terry 
Published: August 2017

ABSTRACTObjectiveSocial media provides us with a new platform on which to explore how the public responds to disasters and, of particular importance, how they respond to the emergence of infectious diseases such as Ebola. Provided it is appropriately informed, social media offers a potentially powerful means of supporting both early detection and effective containment of communicable diseases, which is essential for improving disaster medicine and public health preparedness.MethodsThe 2014 West African Ebola outbreak is a particularly relevant contemporary case study on account of the large number of annual arrivals from Africa, including Chinese employees engaged in projects in Africa. Weibo (Weibo Corp, Beijing, China) is China’s most popular social media platform, with more than 2 billion users and over 300 million daily posts, and offers great opportunity to monitor early detection and promotion of public health awareness.ResultsWe present a proof-of-concept study of a subset of Weibo posts during the outbreak demonstrating potential and identifying priorities for improving the efficacy and accuracy of information dissemination. We quantify the evolution of the social network topology within Weibo relating to the efficacy of information sharing.ConclusionsWe show how relatively few nodes in the network can have a dominant influence over both the quality and quantity of the information shared. These findings make an important contribution to disaster medicine and public health preparedness from theoretical and methodological perspectives for dealing with epidemics. (Disaster Med Public Health Preparedness. 2018;12:26–37)
A unique winged euthycarcinoid from the Permian of Antarctica
Authors: Collette Joseph H. , Isbell John L. , Miller Molly F. 
Published: August 2017

AbstractEuthycarcinoid arthropods (Cambrian–Triassic) were likely the first animals to transition from oceanic to freshwater and emergent environments. Although their basic bauplan is well known, they have a poor fossil record because their non-sclerotized exoskeleton was rarely preserved. Euthycarcinoids’ unusual morphology (varying numbers of body segments, seemingly dichotomous possession of either mandibles or a labrum, specialized or generalized limbs, and possession by some euthycarcinoid species of sternal pores—structures possibly analogous to coxal vesicles in myriapods) contribute to uncertainty regarding their relationship to other arthropod groups; while their poor fossil record masks the evolutionary transitions within and between the separate realms they inhabited (marine, freshwater, emergent). A new euthycarcinoid from a Permian polar proglacial lake is described herein that is morphologically unlike all other euthycarcinoids, and interpreted as being well adapted for a nekton-benthic lifestyle. Antarcticarcinus pagoda n. gen. n. sp. possesses a pair of large wing-like processes that project laterally from the preabdominal dorsal exoskeleton. A trace fossil from the overlying Mackellar Formation, cf. Orbiculichnus, which was previously interpreted as having been produced by insects taking off or landing on wet sediments, is reinterpreted herein as being produced by A. pagoda n. gen. n. sp. due to the high degree of morphological similarity between traces and body fossils. This occurrence indicates that euthycarcinoids were able to adapt to life in temperate freshwater environments, while possible subaerial adaptations hint at an ability to breathe air. Indeed, if euthycarcinoids could breathe air, Cambrian terrestrial forays and rapid transition (by the Ordovician) into freshwater environments might be explained.
Bouldery slope landforms on Mt. Biseul, Korea, and implications for paleoclimate and slope evolution
Authors: Rhee Hyun-Hee , Seong Yeong-Bae , Jeon Young-Gweon , Yu Byung-Yong 
Published: August 2017

AbstractIdentification of bouldery landforms in mountains and correctly understanding their formative processes play an important role in reconstructing the geomorphic history of a region. We propose that blocks were liberated by frost cracking and wedging of cliff walls during the last glacial period. However, we further suggest and test four hypotheses comprising different scenarios for preconditioning by chemical weathering and subsequent block transport using terrain analysis, characterization of boulders, and10Be exposure dating. Frost shattering from the backing cliff produced the boulders since the beginning of the last glacial period (~80 ka), and gelifluction transported them downslope throughout the last glacial period. Their activity then entered a dormant phase at the beginning of the Holocene. Distribution patterns of exposure ages of tors and block streams are similar to those of previous studies, implying that bouldery landscapes in the southern Korean Peninsula were likely to be formed by similar processes under periglacial conditions. The timing of active periods in transport of block streams corresponds well with the cold periods identified in regional and global climate proxy records. Interestingly, the activity of block streams in the study area reached a maximum during Marine Oxygen Isotope Stage 3 to 2 when the growth rate of nearby speleothems was lowest.
Social Protection for the Informal Sector in Urban China: Institutional Constraints and Self-selection Behaviour
Authors: JIANG JIN , QIAN JIWEI , WEN ZHUOYI 
Published: August 2017

AbstractThe Chinese government has recently expanded the scope of urban social insurance programmes. However, social protection for the labour force of the urban informal sector, which reaches about half the number of urban workers, lags significantly behind. This under-coverage may be due to institutional constraints, particularly the household registration system hukou, and self-selection behaviour related to the limited benefits of social insurance. Drawing on a recent nationwide individual-level survey and city-level statistics, this study examines these two explanations for the under-enrolment on the social insurance programme. First, results suggest that hukou and the intergovernmental fiscal system are major institutional constraints. Second, self-selection behaviour in programme enrolment is verified. Employers in the informal sector are likely to opt out of social insurance. More importantly, employers in the informal sector, with rural or non-local hukou, are likely to opt out of social insurance, which suggests that self-selection behaviour is constrained by institutions. Such findings have important implications for broad theoretical and policy debates on universal social protection.
Stability results for local zeta functions of groups algebras, and modules
Authors: ROSSMANN TOBIAS 
Published: August 2017

AbstractVarious types of local zeta functions studied in asymptotic group theory admit two natural operations: (1) change the prime and (2) perform local base extensions. Often, the effects of both of the preceding operations can be expressed simultaneously in terms of a single formula, a statement made precise using what we call local maps of Denef type. We show that assuming the existence of such formulae, the behaviour of local zeta functions under variation of the prime in a set of density 1 in fact completely determines these functions for almost all primes and, moreover, it also determines their behaviour under local base extensions. We discuss applications to topological zeta functions, functional equations, and questions of uniformity.
Utility of Ambulance Data for Real-Time Syndromic Surveillance: A Pilot in the West Midlands Region, United Kingdom
Authors: Todkill Dan , Loveridge Paul , Elliot Alex J. , Morbey Roger A. , Edeghere Obaghe , Rayment-Bishop Tracy , Rayment-Bishop Chris , Thornes John E. , Smith Gillian 
Published: August 2017

AbstractIntroductionThe Public Health England (PHE; United Kingdom) Real-Time Syndromic Surveillance Team (ReSST) currently operates four national syndromic surveillance systems, including an emergency department system. A system based on ambulance data might provide an additional measure of the “severe” end of the clinical disease spectrum. This report describes the findings and lessons learned from the development and preliminary assessment of a pilot syndromic surveillance system using ambulance data from the West Midlands (WM) region in England.Hypothesis/ProblemIs an Ambulance Data Syndromic Surveillance System (ADSSS) feasible and of utility in enhancing the existing suite of PHE syndromic surveillance systems?MethodsAn ADSSS was designed, implemented, and a pilot conducted from September 1, 2015 through March 1, 2016. Surveillance cases were defined as calls to the West Midlands Ambulance Service (WMAS) regarding patients who were assigned any of 11 specified chief presenting complaints (CPCs) during the pilot period. The WMAS collected anonymized data on cases and transferred the dataset daily to ReSST, which contained anonymized information on patients’ demographics, partial postcode of patients’ location, and CPC. The 11 CPCs covered a broad range of syndromes. The dataset was analyzed descriptively each week to determine trends and key epidemiological characteristics of patients, and an automated statistical algorithm was employed daily to detect higher than expected number of calls. A preliminary assessment was undertaken to assess the feasibility, utility (including quality of key indicators), and timeliness of the system for syndromic surveillance purposes. Lessons learned and challenges were identified and recorded during the design and implementation of the system.ResultsThe pilot ADSSS collected 207,331 records of individual ambulance calls (daily mean=1,133; range=923-1,350). The ADSSS was found to be timely in detecting seasonal changes in patterns of respiratory infections and increases in case numbers during seasonal events.ConclusionsFurther validation is necessary; however, the findings from the assessment of the pilot ADSSS suggest that selected, but not all, ambulance indicators appear to have some utility for syndromic surveillance purposes in England. There are certain challenges that need to be addressed when designing and implementing similar systems.TodkillD,LoveridgeP,ElliotAJ,MorbeyRA,EdeghereO,Rayment-BishopT,Rayment-BishopC,ThornesJE,SmithG.Utility of ambulance data for real-time syndromic surveillance: a pilot in the West Midlands region, United Kingdom.Prehosp Disaster Med.2017;32(6):667–672.
INFINITARY PROPOSITIONAL RELEVANT LANGUAGES WITH ABSURDITY
Authors: BADIA GUILLERMO 
Published: August 2017

AbstractAnalogues of Scott’s isomorphism theorem, Karp’s theorem as well as results on lack of compactness and strong completeness are established for infinitary propositional relevant logics. An “interpolation theorem” (of a particular sort introduced by Barwise and van Benthem) for the infinitary quantificational boolean logicL∞ωholds. This yields a preservation result characterizing the expressive power of infinitary relevant languages with absurdity using the model-theoretic relation of relevant directed bisimulation as well as a Beth definability property.
Gradient light interference microscopy for 3D imaging of unlabeled specimens
Authors: Nguyen Tan H. , Kandel Mikhail E. , Rubessa Marcello , Wheeler Matthew B. , Popescu Gabriel 
Published: August 2017

AbstractMultiple scattering limits the contrast in optical imaging of thick specimens. Here, we present gradient light interference microscopy (GLIM) to extract three-dimensional information from both thin and thick unlabeled specimens. GLIM exploits a special case of low-coherence interferometry to extract phase information from the specimen, which in turn can be used to measure cell mass, volume, surface area, and their evolutions in time. Because it combines multiple intensity images that correspond to controlled phase shifts between two interfering waves, gradient light interference microscopy is capable of suppressing the incoherent background due to multiple scattering. GLIM can potentially become a valuable tool for in vitro fertilization, where contrast agents and fluorophores may impact the viability of the embryo. Since GLIM is implemented as an add-on module to an existing inverted microscope, we anticipate that it will be adopted rapidly by the biological community.
Inorganic carbon distribution and CO2 fluxes in a large European estuary (Tagus, Portugal)
Authors: Oliveira A. P. , Cabeçadas G. , Mateus M. D. 
Published: August 2017

AbstractTen field cruises were carried out in Tagus estuary from 1999 to 2007 to study the dynamics of the inorganic carbon system. Dissolved inorganic carbon (DIC) and total alkalinity (TA) increased with salinity. DIC and TA were generally conservative in the estuarine mixing zone (salinity > 10), while a complex distribution pattern was observed at the upper estuary. DIC values peaked 1786.9 ± 155.8 µmol kg−1 at that segment. Estimated annual mean fluxes of DIC were 0.27 Tg C yr−1 from the river to the estuary, and 0.37 Tg C yr−1 from here to the coastal area. The Tagus estuary was always CO2 supersaturated, with partial pressure of CO2 (pCO2) reaching 9160 µatm in the upper estuary. An average emission of 0.11 Tg C yr−1 was estimated from the estuary to the atmosphere, corresponding to 23% of exported DIC. Only 8% of the riverine DIC was ventilated. The non-conservative behaviour of CO2 parameters in the estuary segment under freshwater influence was attributed to alternations in the relevance of riverine/terrestrial runoff, photosynthesis, aerobic respiration, organic matter mineralization and CaCO3 precipitation/dissolution.
Shannon entropy of brain functional complex networks under the influence of the psychedelic Ayahuasca
Authors: Viol A. , Palhano-Fontes Fernanda , Onias Heloisa , de Araujo Draulio B. , Viswanathan G. M. 
Published: August 2017

AbstractThe entropic brain hypothesis holds that the key facts concerning psychedelics are partially explained in terms of increased entropy of the brain’s functional connectivity. Ayahuasca is a psychedelic beverage of Amazonian indigenous origin with legal status in Brazil in religious and scientific settings. In this context, we use tools and concepts from the theory of complex networks to analyze resting state fMRI data of the brains of human subjects under two distinct conditions: (i) under ordinary waking state and (ii) in an altered state of consciousness induced by ingestion of Ayahuasca. We report an increase in the Shannon entropy of the degree distribution of the networks subsequent to Ayahuasca ingestion. We also find increased local and decreased global network integration. Our results are broadly consistent with the entropic brain hypothesis. Finally, we discuss our findings in the context of descriptions of “mind-expansion” frequently seen in self-reports of users of psychedelic drugs.
Three-terminal resistive switch based on metal/metal oxide redox reactions
Authors: Huang Mantao , Tan Aik Jun , Mann Maxwell , Bauer Uwe , Ouedraogo Raoul , Beach Geoffrey S. D. 
Published: August 2017

AbstractA solid-state three-terminal resistive switch based on gate-voltage-tunable reversible oxidation of a thin-film metallic channel is demonstrated. The switch is composed of a cobalt wire placed under a GdOx layer and a Au top electrode. The lateral resistance of the wire changes with the transition between cobalt and cobalt oxide controlled by a voltage applied to the top electrode. The kinetics of the oxidation and reduction process are examined through time- and temperature-dependent transport measurements. It is shown that that reversible voltage induced lateral resistance switching with a ratio of 103 can be achieved at room temperature. The reversible non-volatile redox reaction between metal and metal oxide may provide additional degrees of freedom for post-fabrication control of properties of solid-state materials. This type of three-terminal device has potential applications in neuromorphic computing and multilevel data storage, as well as applications that require controlling a relatively large current.
Groundwater rejuvenation in parts of India influenced by water-policy change implementation
Authors: Bhanja Soumendra N. , Mukherjee Abhijit , Rodell Matthew , Wada Yoshihide , Chattopadhyay Siddhartha , Velicogna Isabella , Pangaluru Kishore , Famiglietti James S. 
Published: August 2017

AbstractThe dwindling groundwater resource of India, supporting almost one fifth of the global population and also the largest groundwater user, has been of great concern in recent years. However, in contrary to the well documented Indian groundwater depletion due to rapid and unmanaged groundwater withdrawal, here for the first time, we report regional-scale groundwater storage (GWS) replenishment through long-term (1996–2014, using more than 19000 observation locations) in situ and decadal (2003–2014) satellite-based groundwater storage measurements in western and southern parts of India. In parts of western and southern India, in situ GWS (GWSobs) has been decreasing at the rate of −5.81 ± 0.38 km3/year (in 1996–2001) and −0.92 ± 0.12 km3/year (in 1996–2002), and reversed to replenish at the rate of 2.04 ± 0.20 km3/year (in 2002–2014) and 0.76 ± 0.08 km3/year (in 2003–2014), respectively. Here, using statistical analyses and simulation results of groundwater management policy change effect on groundwater storage in western and southern India, we show that paradigm shift in Indian groundwater withdrawal and management policies for sustainable water utilization appear to have started replenishing the aquifers in western and southern parts of India.
Experimental study on the location of an acoustic emission source considering refraction in different media
Authors: Zhou Zi-long , Zhou Jing , Dong Long-jun , Cai Xin , Rui Yi-chao , Ke Chang-tao 
Published: August 2017

AbstractThe existing acoustic emission (AE) source location methods assume that acoustic waves propagate along straight lines, and the source location is determined by average wave velocity. Because of the heterogeneity of materials, location results often fail to meet the accuracy requirement. For this reason, an AE source location method considering refraction in different media was proposed in this paper. According to sensor coordinates, the arrival time of acoustic waves, the velocities of acoustic waves in two kinds of media, the space-time relation equations of the AE source point and the measuring point were established by the precise coordinates of the AE source based on Snell’s law. The feasibility of the algorithm was verified by experiments, and the factors influencing location accuracy were also analysed. The results show that the algorithm proposed in this paper is applicable for both the same medium and different media, and the accuracy of localization is not affected by the ratio of wave velocities in two media or the distance from the AE source to the refraction surface.
Machine learning applications for prediction of relapse in childhood acute lymphoblastic leukemia
Authors: Pan Liyan , Liu Guangjian , Lin Fangqin , Zhong Shuling , Xia Huimin , Sun Xin , Liang Huiying 
Published: August 2017

AbstractThe prediction of relapse in childhood acute lymphoblastic leukemia (ALL) is a critical factor for successful treatment and follow-up planning. Our goal was to construct an ALL relapse prediction model based on machine learning algorithms. Monte Carlo cross-validation nested by 10-fold cross-validation was used to rank clinical variables on the randomly split training sets of 336 newly diagnosed ALL children, and a forward feature selection algorithm was employed to find the shortest list of most discriminatory variables. To enable an unbiased estimation of the prediction model to new patients, besides the split test sets of 150 patients, we introduced another independent data set of 84 patients to evaluate the model. The Random Forest model with 14 features achieved a cross-validation accuracy of 0.827 ± 0.031 on one set and an accuracy of 0.798 on the other, with the area under the curve of 0.902 ± 0.027 and 0.904, respectively. The model performed well across different risk-level groups, with the best accuracy of 0.829 in the standard-risk group. To our knowledge, this is the first study to use machine learning models to predict childhood ALL relapse based on medical data from Electronic Medical Record, which will further facilitate stratification treatments.