bluuebunny/crossref_metadata_2025_split huggingface dataset:
An addendum to the problem of numerical computation of the stabilizing solution of periodic game theoretic Riccati differential equation of stochastic control
Authors: Dragan Vasile , Aberkane Samir 
Published: December 2017

Abstract
This note is an addendum to the results reported in Dragan (2014, IMA J. Math. Control Inf.) concerning the numerical computation of the stabilizing solution of periodic game theoretic Riccati differential equation arising in some stochastic control problems. A globally convergent iterative algorithm is proposed for this purpose. The performances of the proposed algorithm are illustrated on some numerical examples.
Recovery-Based Interprofessional Distance Education (RIDE)
Authors: Beebe Lora Humphrey , Roman Marian , Raynor Hollie , Thompson Dixie , Franks Andrea 
Published: December 2017

Abstract
Graduate student attitudes (n = 28) were assessed before and after participation in interprofessional practitioner education (IPE). Twenty-eight graduate students participated (14 mental health nursing, 6 pharmacy, 4 nutrition, 4 exercise physiology); most had at least some health care experience. Posttest scores indicated gains on a majority of constructs measured. These results suggest that online-blended IPE content yields gains in team skills and attitudes. This study adds to a very small body of literature on IPE in graduate programs. More research is needed in examining online versus face-to-face delivery.
Integrating Gerontology and Community Concepts Through Simulation
Authors: DeBrew Jacqueline Kayler , Hensley-Hannah Susan 
Published: December 2017

Abstract
This article describes an innovative simulation experience for nursing students. Faculty from a community health nursing course and a course in gerontology worked together to provide a comprehensive simulation experience that combined low-fidelity and high-fidelity experiences that provided an integrated learning experience and gave faculty with an opportunity to collaborate to improve outcomes. Student and faculty feedback was overwhelmingly positive. Future plans include incorporating a third didactic course, Leadership and Management, and working with other disciplines to demonstrate interprofessional collaboration.
An Intervention to Improve Cultural Competence in Graduate Nursing Education
Authors: Creech Constance , Filter Marilyn , Wehbe-Alamah Hiba , McFarland Marilyn R. , Andrews Margaret , Pryor Gwendolyn 
Published: December 2017

Abstract
Noting the small number of studies on the influence of an entire curriculum on graduate nursing students’ cultural competence, the researchers examined the effect of a curricular intervention using a pretest-posttest design. The study, conducted from 2012 to 2014, focused solely on the Doctor of Nursing Practice program at a midwestern university. Results from a pre- and postintervention faculty curriculum survey indicated that the percentage of courses including a cultural competence objective increased from 65 percent to 81 percent. Results from the pre- and postintervention administration of the Transcultural Self-Efficacy Tool showed a statistically significant improvement in students’ overall score and three subscale scores.
Assessment of Nursing Student Confidence Using the Clinical Skills Self-Efficacy Scale
Authors: Van Horn Elizabeth , Christman Jeanne 
Published: December 2017

Abstract
Student self-efficacy related to clinical skills is important to successful performance in the clinical setting. This pilot study was designed to evaluate the confidence levels of junior and senior nursing students in performing selected nursing skills, using the Clinical Skills Self-Efficacy Scale. A descriptive cross-sectional design was used in which participants completed an online survey. Findings indicate that senior students demonstrated higher self-efficacy than juniors; their experiences and confidence related to performing specific clinical skills varied across groups. Strategies to improve students’ clinical skills learning specific to the laboratory and clinical settings are addressed.
Flipping an Undergraduate Gerontological Nursing Course
Authors: Dabney Beverly Waller , Mitchell Ronald 
Published: December 2017

Abstract
A flipped classroom instructional method was implemented in a gerontological nursing course. Students were surveyed to evaluate their perceptions of the flipped classroom module as well as their satisfaction with it. Open-ended questions were used to explore the students’ best and least favorite aspects of the format. Results indicated that, overall, students were satisfied with and received benefits from the new format; some students experienced frustration in the nonpassive classroom setting. Additional research is needed to determine how to meet the needs of these students and which undergraduate nursing courses are suited for the flipped classroom format.
Utility of Human Papillomavirus Genotyping in the Management of Low-Grade Squamous Intraepithelial Lesions
Authors: Solé-Sedeno Josep M. , Mancebo Gemma , Miralpeix Ester , Lloveras Belen , Bellosillo Beatriz , Alameda Francesc , Carreras Ramon 
Published: December 2017

Objective
The aim of the study was to determine the usefulness of human papillomavirus (HPV) partial genotyping test in the triage of newly diagnosed low-grade squamous intraepithelial lesions (LSILs).

Materials and Methods
We analyzed 143 patients with LSIL diagnosed de novo. Lesions were classified as positive for HPV 16 or HPV 18, positive for HPV but not HPV 16 or HPV 18 (HPVno16no18) or no HPV detected (HPVneg). Patients were followed for a period of 2 years or until the lesion progressed. We calculated absolute and relative risks for progression and regression according to the HPV result.

Results
The mean (SD) age was 33.8 (11.1) years. A total of 19.6% were positive for HPV 16, 4.9% for HPV 18, and 63.6% for HPVno16no18. The absolute risk of HPV 16 for progression to cervical intraepithelial neoplasia grade 2 or more (CIN 2+) was 32.1%, 14.3% for HPV 18, and 5.8% for HPVno16no18. None of the HPVneg cases evolved to CIN 2+. The presence of HPV 16 conferred a 7.4 (95% CI = 2.7–20.3) times greater risk of developing CIN 2+ than its absence. The absolute risks for HPV 16, HPV 18, HPVno16no18, and HPVneg for regression were 53.6%, 57.1%, 75.4%, and 87.5%, respectively. Relative risks for regression were 0.7 (95% CI = 0.5–0.9) for HPV 16 and 1.3 (95% CI = 1.1–1.5) for HPVneg.

Conclusions
The HPV 16 LSILs are more likely to progress to CIN 2+, so tight control and immediate colposcopy are crucial, whereas when HPV 16 is not present, follow-up could be less strict. Low-grade squamous intraepithelial lesions in which high-risk HPV is not detected do not progress to CIN 2+, so its control should be different from other LSIL, and conservative management could be an acceptable strategy.
Photodynamic Therapy for Vulvar Lichen Sclerosus—A Systematic Review
Authors: Prodromidou Anastasia , Chatziioannou Eftychia , Daskalakis Georgios , Stergios Kostantinos , Pergialiotis Vasilios 
Published: December 2017

Objective
Lichen sclerosus (LS) is a disease affecting mostly genital and perianal areas. Photodynamic therapy (PDT) has gained interest during the past years. The present study accumulates current evidence on the efficacy of PDT in the management of vulvar LS.

Methods
We used Medline (1966–2017), Scopus (2004–2017), ClinicalTrials.gov (2008–2017) and Cochrane Central Register of Controlled Trials CENTRAL (1999–2017) databases in our primary search along with the reference lists of electronically retrieved full-text papers.

Results
Eleven studies were finally included in our systematic review, which recruited 337 women. The existing evidence supports that PDT results in significant relief of symptoms related to LS, hence remains confusing in evaluating the progress in the clinical appearance of the lesion. No major adverse effects were reported during therapy and during the posttreatment period. Pathologic findings seem to be conflicting, as current data do not unanimously support a beneficial histological effect.

Conclusions
According to the findings of our study, PDT seems to be promising in the treatment of patients with vulvar LS. Nonetheless, current knowledge is extremely limited, and further observational studies with large patient series are needed in the field to elucidate the efficacy of PDT.
Abacavir usage patterns and hypersensitivity reactions in the EuroSIDA cohort
Authors: Roen A , Laut K , Pelchen‐Matthews A , Borodulina E , Caldeira L , Clarke A , Clotet B , d'Arminio Monforte A , Fätkenheuer G , Gatell Artigas JM , Karpov I , Kuznetsova A , Kyselyova G , Mozer‐Lisewska I , Mulcahy F , Ragone L , Scherrer A , Uzdaviniene V , Vandekerckhove L , Vannappagari V , Ostergaard L , Mocroft A ,   on behalf of the EuroSIDA study
Published: December 2017

ObjectivesFive to eight per cent of HIV‐positive individuals initiating abacavir (ABC) experience potentially fatal hypersensitivity reactions (HSRs). We sought to describe the proportion of individuals initiating ABC and to describe the incidence and factors associated with HSR among those prescribed ABC.MethodsWe calculated the proportion of EuroSIDA individuals receiving ABC‐based combination antiretroviral therapy (cART) among those receiving cART after 1 January 2009. Poisson regression was used to identify demographic, and current clinical and laboratory factors associated with ABC utilization and discontinuation.ResultsBetween 2009 and 2016, of 10 076 individuals receiving cART, 3472 (34%) had ever received ABC‐based cART. Temporal trends of ABC utilization were also heterogeneous, with 28% using ABC in 2009, dropping to 26% in 2010 and increasing to 31% in 2016, and varied across regions and over time. Poisson models showed lower ABC utilization in older individuals, and in those with higher CD4 cell counts, higher cART lines, and prior AIDS. Higher ABC utilization was associated with higher HIV RNA and poor renal function, and was more common in Central‐East and Eastern Europe and lowest during 2014. During 779 person‐years of follow‐up (PYFU) in 2139 individuals starting ABC after 1 January 2009, 113 discontinued ABC within 6 weeks of initiation for any reason [incidence rate (IR) 14.5 (95% confidence interval (CI) 12.1, 17.5) per 100 PYFU], 13 because of reported HSR [IR 0.3 (95% CI 0.1, 1.0) per 100 PYFU] and 35 because of reported HSR/any toxicity [IR 4.5 (95% CI 3.2, 6.3) per 100 PYFU]. There were no factors significantly associated with ABC discontinuation because of reported HSR/any toxicity.ConclusionsABC remains commonly used across Europe and the incidence of discontinuation because of reported HSR was low in our study population.
Telephone Follow‐Up for Older Adults Discharged to Home from the Emergency Department: A Pragmatic Randomized Controlled Trial
Authors: Biese Kevin J. , Busby‐Whitehead Jan , Cai Jianwen , Stearns Sally C. , Roberts Ellen , Mihas Paul , Emmett Doug , Zhou Qingning , Farmer Franklin , Kizer John S. 
Published: December 2017

Background/ObjectivesTelephone calls after discharge from the emergency department (ED) are increasingly used to reduce 30‐day rates of return or readmission, but their effectiveness is not established. The objective was to determine whether a scripted telephone intervention by registered nurses from a hospital‐based call center would decrease 30‐day rates of return to the ED or hospital or of death.DesignRandomized, controlled trial from 2013 to 2016.SettingLarge, academic medical center in the southeast United States.ParticipantsIndividuals aged 65 and older discharged from the ED were enrolled and randomized into intervention and control groups (N = 2,000).InterventionIntervention included a telephone call from a nurse using a scripted questionnaire to identify obstacles to elements of successful care transitions: medication acquisition, postdischarge instructions, and obtaining physician follow‐up. Control subjects received a satisfaction survey only.MeasurementsPrimary outcome was return to the ED, hospitalization, or death within 30 days of discharge from the ED.ResultsRate of return to the ED or hospital or death within 30 days was 15.5% (95% confidence interval (CI) = 13.2–17.8%) in the intervention group and 15.2% (95% CI = 12.9–17.5%) in the control group (P = .86). Death was uncommon (intervention group, 0; control group, 5 (0.51%), 95% CI = 0.06–0.96%); 12.2% of intervention subjects (95% CI = 10.1–14.3%) and 12.5% of control subjects (95% CI = 10.4–14.6%) returned to the ED, and 9% of intervention subjects (95% CI = 7.2–10.8%) and 7.4% of control subjects (95% CI = 5.8–9.0%) were hospitalized within 30 days.ConclusionA scripted telephone call from a trained nurse to an older adult after discharge from the ED did not reduce ED or hospital return rates or death within 30 days. Clinicaltrials.gov identifier: NCT01893931z.
The lifetime costs of overweight and obesity in childhood and adolescence: a systematic review
Authors: Hamilton D. , Dee A. , Perry I. J. 
Published: December 2017

SummaryBackgroundResearch into lifetime costs of obesity in childhood is growing. This review synthesizes that knowledge.MethodologyA computerized search of the international literature since 2000 was conducted. Mean total lifetime healthcare and productivity costs were estimated and inflated to 2014 Irish euros.ResultsThis resulted in 13 published articles. The methodology used in these studies varied widely, and only one study estimated both healthcare and productivity costs. Cognizant of this heterogeneity, the mean total lifetime cost of a child or adolescent with obesity was €149,206 (range, €129,410 to €178,933) for a boy and €148,196 (range, €136,576 to €173,842) for a girl. This was divided into an average of €16,229 (range, €6,580 to €35,810) in healthcare costs and €132,977 (range, €122,830 to €143,123) in productivity losses for boys and €19,636 (range, €8,016 to €45,283) and €128,560, respectively, for girls. Income penalty accounted for the greater part of productivity costs, amounting to €97,118 (range, €86,971 to €107,264) per male adolescent with obesity and €126,108 per female adolescent.ConclusionsHealthcare costs and income penalty appear greater in girls while costs because of workdays lost seem greater in boys. There is proportionality between body mass index and costs. Productivity costs are greater than healthcare costs.
Diagnostic spectrum and 2-year outcome in a cohort of patients with very early arthritis
Authors: Norli Ellen Sauar , Brinkmann Gina Hetland , Kvien Tore Kristian , Bjørneboe Olav , Haugen Anne Julsrud , Nygaard Halvor , Thunem Cathrine , Lie Elisabeth , Mjaavatten Maria Dahl 
Published: December 2017

ObjectivesTo describe the diagnostic spectrum, arthritis persistency and clinical outcomes after 2 years in patients with inflammatory arthritis (IA) of less than 16 weeks’ duration.MethodsData from the Norwegian Very Early Arthritis Clinic, a 2-year longitudinal observational study of adults with IA of ≤16 weeks’ duration, were used. Exclusion criteria were arthritis due to crystal deposits, trauma, osteoarthritis and septic arthritis. In all patients who had any follow-up information (population A), clinical diagnoses and persistency of arthritis were described. For patients with 2-year follow-up (population B), we also studied other clinical outcomes (disease activity, pain, fatigue, functional disability and health-related quality of life).ResultsIn population A (n=1017) median (25th–75th percentile) duration of joint swelling was 35.0 (13.0–66.5) days, mean (SD) age 45.7 (14.8) years, 55.2% were females and 17.8% anticitrullinated protein antibodies positive. The most common final diagnoses were undifferentiated arthritis (UA) (41.7%), rheumatoid arthritis (RA) (24.1%) and reactive arthritis (18.1%). After 2 years, the arthritis had resolved in 59% of the patients. The remaining 41.0% had persistent disease defined by disease modifying antirheumatic drug (DMARD) use (32.1%) or persistent joint swelling without DMARD use (8.9%). In population B (n=669), all clinical outcomes improved significantly (P<0.001). Baseline joint pain and fatigue were similar across diagnoses.ConclusionsAmong 1017 patients with IA of ≤16 weeks’ duration, UA was the most common diagnosis after 2 years, and less than one-fourth were diagnosed with RA. Arthritis resolved without DMARDs in the majority of the patients. All clinical parameters improved significantly over a 2-year course.
Disruption of microtubules alters polarity of basement membrane proteoglycan secretion in epithelial cells
Authors: de Almeida J. Bruno , Stow Jennifer L. 
Published: December 2017

Basement membrane proteins such as the heparan sulfate proteoglycan (HSPG) are secreted in a polarized fashion from the basolateral membrane of epithelial cells. We have used the microtubule-disrupting drug colchicine to study the role of the microtubule network in directing constitutive secretion to the basolateral membrane of LLC-PK1 renal epithelial cells. Microtubule depolymerization induced by colchicine resulted in fragmentation and redistribution of fluorescently labeled trans-Golgi membranes. Increased immunofluorescent staining of HSPG was associated with these dispersed Golgi cisternae. The biosynthetic processing of HSPG was not significantly altered by the loss of microtubules or by the dispersal of the Golgi elements. The most striking effect of microtubule disruption was the loss of polarity of HSPG secretion. Immunoprecipitation studies showed that HSPG was secreted from both apical and basolateral surfaces of LLC-PK1 cells treated with colchicine, and a similar result was found for the delivery of laminin, another basement membrane protein. In contrast, there was no change in the distribution of an integral basolateral membrane protein, Na+-K+-ATPase, following colchicine treatment. Our results provide the first demonstration that microtubules are involved in the constitutive trafficking of basolateral secretory proteins. These data also suggest that there may be an inherent difference in the targeting or delivery of membrane and secretory proteins to the basolateral cell surface. polarized secretion; heparan sulfate proteoglycans; sorting; Golgi processing Submitted on July 10, 1990 Accepted on November 12, 1990
Differential effects of cytokines on long-term mitogenic and secretory responses of fetal rat pancreatic βcells
Authors: Sjöholmöholm A. 
Published: December 2017

Pages C116 and C118: Å. Sjőholm. “Differential effects of cytokines on long-term mitogenic and secretory responses of fetal rat pancreatic betacells.” Page C116, Table 1, the units for [Glucose] should read mM, and page C118, Table 3, the units for [IFN-ggr should read U/ml, as shown in the corrected tables. (The errors were inadvertentlv introduced by the printer at the final stage of proof.) (See PDF)
cAMP-independent regulation of CFTR by the actin cytoskeleton
Authors: Prat A. G. , Xiao Y. -F. , Ausiello D. A. , Cantiello H. F. 
Published: December 2017

Pages C1552<C1561: A. G. Prat, Y.-F. Xiao, D. A. Ausiello, and H. F. Cantiello. “cAMP-independent regulation of CFTR by the actin cytoskeleton.” Page C1558, Fig. 8A: units on the y-axis of the bar graph should have been 10 times larger. The corrected figure appears below. (See PDF)
Muscarinic stimulation of tracheal smooth muscle cells activates large-conductance Ca2+-dependent K+ channel
Authors: Wade G. R. , Sims S. M. 
Published: December 2017

Pages C658-C665: G. R. Wade and S. M. Sims. “Muscarinic stimulation of tracheal smooth muscle cells activates large-conductance Ca2+-dependent K+ channel.” Page C662, Fig. 6: the second half of the trace in A was inadvertently duplicated from B. The revised Fig. 6 below shows the correct channel traces. We wish to emphasize that the scientific point of the figure, the reversible antagonism of the cholinergic response by atropine, as well as the quantification in D, remains sound. The data were filtered at 400 Hz and sampled off-line from digital videotape at 2 kHz. (See PDF)
Cionin, a protochordean hybrid of cholecystokinin and gastrin: biological activity in mammalian systems
Authors: Schjoldager Birgit , Park Jung , Johnsen Anders H. , Yamada Tadataka , Rehfeld Jens F. 
Published: December 2017

The protochordean octapeptide cionin is structurally a hybrid of mammalian cholecystokinin (CCK) and gastrin, and thus their possible common ancestor. To determine whether cionin behaves like CCK or gastrin, we examined its effect on canine fundic somatostatin cells and on porcine and bovine gallbladder muscles. Cionin released somatostatin with a potency (ED50 0.15 nM) and efficacy (14.8% of cell content) similar to that of CCK-8 (ED50 0.12 nM, efficacy 16.7%). The efficacies but not the potencies of CCK-8 and cionin differed from those of sulfated gastrin (0.12 nM, 9.7%), nonsulfated gastrin (0.20 nM, 9.4%), and nonsulfated CCK-8 (0.30 nM, 10.4%). CCK and gastrin stimulated contractions of porcine gallbladder muscle strips in a concentration-dependent manner with no differences in efficacy but with characteristic differences in potency. CCK-8 and cionin displayed similar potencies of ED50 2.0 and 2.6 nM; both were significantly different from the ED50 of 0.4 μM for sulfated gastrin and 2.3 μM for nonsulfated gastrin. CCK radioligand binding to membrane-enriched preparations of porcine and bovine gallbladder muscularis was specific and of high affinity. The equilibrium data revealed that binding of CCK and gastrin peptides best fit a single site. CCK-8 and cionin displayed similar affinities [Kd 0.5 nM (porcine), 0.5 nM (bovine, CCK) vs. Kd 0.8 and 0.9 nM (cionin), respectively]. These differed again significantly from Kd 0.6 and 1.5 μM (sulfated gastrin) and 0.7 and 0.2 μM (nonsulfated gastrin). The results show that cionin behaves like CCK rather than gastrin in mammals. gallbladder motility; somatostatin; receptors Submitted on August 10, 1990 Accepted on December 19, 1990
Neural mechanism underlying tachycardia induced by nonhypotensive a-v shunt
Authors: Gupta P. D. , Singh M. 
Published: December 2017

The mechanism underlying tachycardia resulting from nonhypotensive arteriovenous shunt (shunt open plus infusion of blood to compensate for the fall in mean arterial pressure resulting from opening of a shunt) was investigated in anesthetized, artificially ventilated dogs. In dogs with intact autonomic innervation, dogs with beta-adrenergic blockade (BB), and dogs with BB plus spinal section at C7 (BBSS), opening of the shunt resulted in tachycardia ( P < 0.01 for all comparisons), which was, however, not significantly different on comparison among groups ( P > 0.40 for all comparisons). This shows that afferent and efferent sympathetic-mediated reflexes do not play a significant role in this tachycardia response. Additionally, the tachycardia response was significant in dogs with BBSS plus right or left vagotomy, but it was completely abolished in dogs with BBSS plus bilateral vagotomy. This suggests that in dogs with blockade of sympathetic afferent and efferent pathways, tachycardia resulting from nonhypotensive arteriovenous shunt may be due to a cardioacceleratory reflex with its ascending and its descending pathways in each vagus nerve. dog; heart rate; cardiac sympathetic efferents; spinal dog; cardioacceleratory reflex; vagovagal reflex; vagosympathetic reflex; spinovagal reflex; spinal afferents; vagal afferents; vagal efferents; arterial baroreceptors; beta-adrenergic blockade; vagotomy; nervous control of heart rate; propranolol Submitted on May 12, 1978 Accepted on August 29, 1978
CARBON DIOXIDE PRODUCTION FROM NERVE FIBRES WHEN RESTING AND WHEN STIMULATED; A CONTRIBUTION TO THE CHEMICAL BASIS OF IRRITABILITY
Authors: Tashiro Shiro 
Published: December 2017

in June number of the American Journal of Physiology (Vol. XXXII., No. II). Substitute " apparatus" for " apparati" in the following places: page 110, lines 7, 11, 23. page 129, line 1. page 137, line 28. page 138, lines 1, 3. page 144, line 6. Substitute " 7.1 c.c." for " 1.1 c.c." on page 144, line 29. In figure 1, page 120, correct as indicated the following drawing: (See PDF)