bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why Sketching May Aid Learning From Science Texts: Contrasting Sketching With Written Explanations
Authors: Scheiter Katharina , Schleinschok Katrin , Ainsworth Shaaron 
Published: March 2017

AbstractThe goal of this study was to explore two accounts for why sketching during learning from text is helpful: (1) sketching acts like other constructive strategies such as self‐explanation because it helps learners to identify relevant information and generate inferences; or (2) that in addition to these general effects, sketching has more specific benefits due to the pictorial representation that is constructed. Seventy‐three seventh‐graders (32 girls, M = 12.82 years) were first taught how to either create sketches or self‐explain while studying science texts. During a subsequent learning phase, all students were asked to read an expository text about the greenhouse effect. Finally, they were asked to write down everything they remembered and then answer transfer questions. Strategy quality during learning was assessed as the number of key concepts that had either been sketched or mentioned in the self‐explanations. The results showed that at an overall performance level there were only marginal group differences. However, a more in‐depth analysis revealed that whereas no group differences emerged for students implementing either strategy poorly, the sketching group clearly outperformed the self‐explanation group for students who applied the strategies with higher quality. Furthermore, higher sketching quality was strongly related to better learning outcomes. Thus, the study's results are more in line with the second account: Sketching can have a beneficial effect on learning above and beyond generating written explanations; at least, if well deployed.
Seroprevalence of Bartonella species, Coxiella burnetii and Toxoplasma gondii among patients with hematological malignancies: A pilot study in Romania
Authors: Messinger C. J. , Gurzau E. S. , Breitschwerdt E. B. , Tomuleasa C. I. , Trufan S. J. , Flonta M. M. , Maggi R. G. , Berindan‐Neagoe I. , Rabinowitz P. M. 
Published: March 2017

SummaryPatients receiving immunosuppressive cancer treatments in settings where there is a high degree of human–animal interaction may be at increased risk for opportunistic zoonotic infections or reactivation of latent infections. We sought to determine the seroprevalence of selected zoonotic pathogens among patients diagnosed with haematologic malignancies and undergoing chemotherapeutic treatments in Romania, where much of the general population lives and/or works in contact with livestock. A convenience sample of 51 patients with haematologic cancer undergoing chemotherapy at a referral clinic in Cluj‐Napoca, Romania, was surveyed regarding animal exposures. Blood samples were obtained and tested for evidence of infection with Bartonella species, Coxiella burnetii and Toxoplasma gondii, which are important opportunistic zoonotic agents in immunocompromised individuals. 58.8% of participants reported living or working on a farm, and living or working on a farm was associated with contact with livestock and other animals. 37.5% of participants were IgG seroreactive against one or more of five Bartonella antigens, and seroreactivity was statistically associated with living on farms. Farm dwellers were 3.6 times more likely to test IgG seroreactive to Bartonella antibodies than non‐farm dwellers. 47.1% of the participants tested T. gondii IgG positive and 13.7% tested C. burnetii IgG positive, indicating past or latent infection. C. burnetii IgM antibodies were detected in four participants (7.8%), indicating possible recent infection. These results indicate that a large proportion of patients with haematologic cancer in Romania may be at risk for zoonotic infections or for reactivation of latent zoonotic infections, particularly with respect to Bartonella species. Special attention should be paid to cancer patients' exposure to livestock and companion animals in areas where much of the population lives in rural settings.
The eyes and vision of butterflies
Authors: Arikawa Kentaro 
Published: March 2017

AbstractButterflies use colour vision when searching for flowers. Unlike the trichromatic retinas of humans (blue, green and red cones; plus rods) and honeybees (ultraviolet, blue and green photoreceptors), butterfly retinas typically have six or more photoreceptor classes with distinct spectral sensitivities. The eyes of the Japanese yellow swallowtail (Papilio xuthus) contain ultraviolet, violet, blue, green, red and broad‐band receptors, with each ommatidium housing nine photoreceptor cells in one of three fixed combinations. The Papilio eye is thus a random patchwork of three types of spectrally heterogeneous ommatidia. To determine whether Papilio use all of their receptors to see colours, we measured their ability to discriminate monochromatic lights of slightly different wavelengths. We found that Papilio can detect differences as small as 1–2 nm in three wavelength regions, rivalling human performance. We then used mathematical modelling to infer which photoreceptors are involved in wavelength discrimination. Our simulation indicated that the Papilio vision is tetrachromatic, employing the ultraviolet, blue, green and red receptors. The random array of three ommatidial types is a common feature in butterflies. To address the question of how the spectrally complex eyes of butterflies evolved, we studied their developmental process. We have found that the development of butterfly eyes shares its molecular logic with that of Drosophila: the three‐way stochastic expression pattern of the transcription factor Spineless determines the fate of ommatidia, creating the random array in Papilio.
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Both standing and postural threat decrease Achilles’ tendon reflex inhibition from tendon electrical stimulation
Authors: Horslen Brian C. , Inglis J. Timothy , Blouin Jean‐Sébastien , Carpenter Mark G. 
Published: March 2017

Key points
Golgi tendon organs (GTOs) and associated Ib reflexes contribute to standing balance, but the potential impacts of threats to standing balance on Ib reflexes are unknown.
Tendon electrical stimulation to the Achilles’ tendon was used to probe changes in Ib inhibition in medial gastrocnemius with postural orientation (lying prone vs. upright standing; experiment 1) and height‐induced postural threat (standing at low and high surface heights; experiment 2).
Ib inhibition was reduced while participants stood upright, compared to lying prone (42.2%); and further reduced when standing in the high, compared to low, threat condition (32.4%).
These experiments will impact future research because they demonstrate that tendon electrical stimulation can be used to probe Ib reflexes in muscles engaged in standing balance.
These results provide novel evidence that human short‐latency GTO‐Ib reflexes are dependent upon both task, as evidenced by changes with postural orientation, and context, such as height‐induced postural threat during standing.
AbstractGolgi tendon organ Ib reflexes are thought to contribute to standing balance control, but it is unknown if they are modulated when people are exposed to a postural threat. We used a novel application of tendon electrical stimulation (TStim) to elicit Ib inhibitory reflexes in the medial gastrocnemius, while actively engaged in upright standing balance, to examine (a) how Ib reflexes to TStim are influenced by upright stance, and (b) the effects of height‐induced postural threat on Ib reflexes during standing. TStim evoked short‐latency (<47 ms) inhibition apparent in trigger‐averaged rectified EMG, which was quantified in terms of area, duration and mean amplitude of inhibition. In order to validate the use of TStim in a standing model, TStim‐Ib inhibition was compared from conditions where participants were lying prone vs. standing upright. TStim evoked Ib inhibition in both conditions; however, significant reductions in Ib inhibition area (42.2%) and duration (32.9%) were observed during stance. Postural threat, manipulated by having participants stand at LOW (0.8 m high, 0.6 m from edge) and HIGH (3.2 m, at edge) elevated surfaces, significantly reduced Ib inhibition area (32.4%), duration (16.4%) and amplitude (24.8%) in the HIGH, compared to LOW, threat condition. These results demonstrate TStim is a viable technique for investigating Ib reflexes in standing, and confirm Ib reflexes are modulated with postural orientation. The novel observation of reduced Ib inhibition with elevated postural threat reveals that human Ib reflexes are context dependent, and the human Ib reflex pathways are modulated by threat or emotional processing centres of the CNS.
Interferon-Inducible Oligoadenylate Synthetase-Like Protein Acts as an Antiviral Effector against Classical Swine Fever Virus via the MDA5-Mediated Type I Interferon-Signaling Pathway
Authors: Li Lian-Feng , Yu Jiahui , Zhang Yuexiu , Yang Qian , Li Yongfeng , Zhang Lingkai , Wang Jinghan , Li Su , Luo Yuzi , Sun Yuan , Qiu Hua-Ji 
Published: March 2017

ABSTRACT

Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), which poses a serious threat to the global pig industry. Interferons (IFNs) and IFN-stimulated genes (ISGs) play a key role in host antiviral defense. We have previously screened the porcine 2′-5′-oligoadenylate synthetase-like protein (pOASL) as a potential anti-CSFV ISG using a reporter CSFV. This study aimed to clarify the underlying antiviral mechanism of pOASL against CSFV. We confirmed that CSFV replication was significantly suppressed in lentivirus-delivered, pOASL-overexpressing PK-15 cells, whereas silencing the expression of endogenous pOASL by small interfering RNAs markedly enhanced CSFV growth. In addition, the transcriptional level of pOASL was upregulated both
in vitro
and
in vivo
upon CSFV infection. Interestingly, the anti-CSFV effects of pOASL are independent of the canonical RNase L pathway but depend on the activation of the type I IFN response. Glutathione
S
-transferase pulldown and coimmunoprecipitation assays revealed that pOASL interacts with MDA5, a double-stranded RNA sensor, and further enhances MDA5-mediated type I IFN signaling. Moreover, we showed that pOASL exerts anti-CSFV effects in an MDA5-dependent manner. In conclusion, pOASL suppresses CSFV replication via the MDA5-mediated type I IFN-signaling pathway.

IMPORTANCE
The host innate immune response plays an important role in mounting the initial resistance to viral infection. Here, we identify the porcine 2′-5′-oligoadenylate synthetase-like protein (pOASL) as an interferon (IFN)-stimulated gene (ISG) against classical swine fever virus (CSFV). We demonstrate that the anti-CSFV effects of pOASL depend on the activation of type I IFN response. In addition, we show that pOASL, as an MDA5-interacting protein, is a coactivator of MDA5-mediated IFN induction to exert anti-CSFV actions. This work will be beneficial to the development of novel anti-CSFV strategies by targeting pOASL.
Nectin-4 Interactions Govern Measles Virus Virulence in a New Model of Pathogenesis, the Squirrel Monkey (Saimiri sciureus)
Authors: Delpeut Sébastien , Sawatsky Bevan , Wong Xiao-Xiang , Frenzke Marie , Cattaneo Roberto , von Messling Veronika 
Published: March 2017

ABSTRACT

In addition to humans, only certain nonhuman primates are naturally susceptible to measles virus (MeV) infection. Disease severity is species dependent, ranging from mild to moderate for macaques to severe and even lethal for certain New World monkey species. To investigate if squirrel monkeys (
Saimiri sciureus
), which are reported to develop a course of disease similar to humans, may be better suited than macaques for the identification of virulence determinants or the evaluation of therapeutics, we infected them with a green fluorescent protein-expressing MeV. Compared to cynomolgus macaques (
Macaca fascicularis
) infected with the same virus, the squirrel monkeys developed more-severe immunosuppression, higher viral load, and a broader range of clinical signs typical for measles. In contrast, infection with an MeV unable to interact with the epithelial receptor nectin-4, while causing immunosuppression, resulted in only a mild and transient rash and a short-lived elevation of the body temperature. Similar titers of the wild-type and nectin-4-blind MeV were detected in peripheral blood mononuclear cells and lymph node homogenates, but only the wild-type virus was found in tracheal lavage fluids and urine. Thus, our study demonstrates the importance of MeV interactions with nectin-4 for clinical disease in the new and better-performing
S. sciureus
model of measles pathogenesis.

IMPORTANCE
The characterization of mechanisms underlying measles virus clinical disease has been hampered by the lack of an animal model that reproduces the course of disease seen in human patients. Here, we report that infection of squirrel monkeys (
Saimiri sciureus
) fulfills these requirements. Comparative infection with wild-type and epithelial cell receptor-blind viruses demonstrated the importance of epithelial cell infection for clinical disease, highlighting the spread to epithelia as an attractive target for therapeutic strategies.
DFT study of elastic, half-metallic and optical properties of Co2V(Al, Ge, Ga and Si) compounds
Authors: Khosravi Heidar , Boochani Arash , Rasolian Golnaz , Solaymani Shahram , Naderi Sirvan 
Published: March 2017

First-principles study of elastic, electronic and optical properties of full-Heusler Co2V(Al, Ge, Ga and Si) compounds are calculated through density functional theory (DFT) to obtain and compare the mentioned properties. Equilibrium lattice constants of these compounds are in good agreement with other works. Electronic calculations are shown full spin polarization at Fermi level for all compounds, so in the down spin, indirect bandgap is calculated as 0.33, 0.6, 0.2 and 0.8 eV for Co2V(Al, Ge, Ga and Si), respectively. The integer amounts of the magnetic moments are compatible with Slater–Pauling role. The optical treatment of Co2VGa is different from three other compounds. All mentioned compounds have metallic behavior by 22 eV plasmonic frequency. The imaginary part of the dielectric function for the up spin indicates that the main optical transitions occurred in this spin mode. Moreover, the elastic results show that the Co2VGa does not have elastic stability, but the other three compounds have fully elastic stability and the Co2V(Al, Ge and Si) belong to the hardness of materials.
Inducing the magnetic character in reduced graphene oxide through incorporation of Fe2O3nanoparticles
Authors: Rauf Abdur , Shah Syed Sohail Ahmad , Rakha Sobia Allah , Gul Munazza , Ahmad Ishaq , Ullah Zaka , Shah Ishfaq Ahmad , Naseem Shahzad 
Published: March 2017

A chemical two-step approach based on solvothermal technique has been adopted to synthesize the reduced graphene oxide (rGO)/Fe2O3hybrid materials. The rGO was prepurified by acidic treatment, followed by sensitization to attach the desired functional groups. The structural, compositional, morphological and magnetic analyzes of the prepared samples were carried out using various characterization techniques. The fabricated rGO/Fe2O3heterostructures were confirmed by X-ray diffraction analysis and Fourier transform infrared spectroscopy. Raman spectroscopy evidenced the fabrication of multilayer graphene and scanning electron microscopy was carried out to study the morphology of the prepared samples. The average particle size of Fe2O3nanoparticles (NPs) loaded on rGO was found to be [Formula: see text]20 nm, as was observed during transmission electron microscopy. Thermogravimetric analysis of rGO/Fe2O3hybrid structures was performed to investigate their thermal behaviors. It was evidenced that the incorporation of Fe2O3NPs into rGO enhanced its thermal stability. Vibrating sample magnetometry showed that ferromagnetic character was induced in rGO due to involvement of Fe2O3NPs. The rGO/Fe2O3hybrid structures can be considered as a competent material for fabrication of various magnetic devices.
Earliest Cretaceous cocoons or plant seed structures from the Wealden Group, Hastings, UK
Authors: Brasier A. T. , Cotton L. J. , Garwood R. J. , Baker-Brian J. , Howlett E. , Brasier M. D. 
Published: March 2017

Abstract
Complete metamorphosis evolved in insects towards the end of the Palaeozoic Era. A wide range of pupation strategies existed and numerous biosedimentary structures associated with these have been described. The fossil record of endogenous materials associated with pupation, e.g. cocoons, is more limited. Here we report six amber-coloured specimens from the earliest Cretaceous of southern England that were tentatively identified on collection as insect cocoons. These were analysed by Fourier transform infrared spectrometry, stereomicroscopy and X-ray microtomography to elucidate their origin. The interpretation of the Fourier transform infrared spectrometry data was inconclusive because the spectra showed some differences from those of amber. A seed pod origin seems likely for at least two of the objects based on their size, shape and the lineations on their surfaces. Three specimens are more cocoon-like based on their overall morphology and a fibrous surface texture. Although plant megaspore membranes have features analogous with these specimens and cannot be ruled out, the similarity to and variability found within insect cocoons, coupled with the range of potential insect architects present at the time of origin, make an insect origin more likely. We review a number of hymenopteran clades whose extant members construct comparable cocoons. The possible cocoons may have been resin-coated to protect the larva inside from predation, or they may have passively come into contact with resin prior to burial.

Supplementary material:
All TIFF computed tomography slices from the scan, the computed tomography log file, a surface model of the specimen and digital visualizations of both the whole specimen and the perforations are available at
https://doi.org/10.6084/m9.figshare.c.3704794
Micro-Sector Cache
Authors: Chaudhuri Mainak , Agrawal Mukesh , Gaur Jayesh , Subramoney Sreenivas 
Published: March 2017

Recent research proposals on DRAM caches with conventional allocation units (64 or 128 bytes) as well as large allocation units (512 bytes to 4KB) have explored ways to minimize the space/latency impact of the tag store and maximize the effective utilization of the bandwidth. In this article, we study sectored DRAM caches that exercise large allocation units called sectors, invest reasonably small storage to maintain tag/state, enable space- and bandwidth-efficient tag/state caching due to low tag working set size and large data coverage per tag element, and minimize main memory bandwidth wastage by fetching only the useful portions of an allocated sector. However, the sectored caches suffer from poor space utilization, since a large sector is always allocated even if the sector utilization is low. The recently proposed Unison cache addresses only a special case of this problem by not allocating the sectors that have only one active block.
We propose Micro-sector cache, a locality-aware sectored DRAM cache architecture that features a flexible mechanism to allocate cache blocks within a sector and a locality-aware sector replacement algorithm. Simulation studies on a set of 30 16-way multi-programmed workloads show that our proposal, when incorporated in an optimized Unison cache baseline, improves performance (weighted speedup) by 8%, 14%, and 16% on average, respectively, for 1KB, 2KB, and 4KB sectors at 128MB capacity. These performance improvements result from significantly better cache space utilization, leading to 18%, 21%, and 22% average reduction in DRAM cache read misses, respectively, for 1KB, 2KB, and 4KB sectors at 128MB capacity. We evaluate our proposal for DRAM cache capacities ranging from 128MB to 1GB.
IGFBP3 Modulates Lung Tumorigenesis and Cell Growth through IGF1 Signaling
Authors: Wang Yong Antican , Sun Yunguang , Palmer Joshua , Solomides Charalambos , Huang Li-Ching , Shyr Yu , Dicker Adam P. , Lu Bo 
Published: March 2017

Abstract
Insulin-like growth factor binding protein 3 (IGFBP3) modulates cell growth through IGF-dependent and -independent mechanisms. Reports suggest that the serum levels of IGFBP3 are associated with various cancers and that IGFBP3 expression is significantly decreased in cisplatin (CDDP)-resistant lung cancer cells. Based on these findings, we investigated whether Igfbp3 deficiency accelerates mouse lung tumorigenesis and if expression of IGFBP3 enhances CDDP response by focusing on the IGF1 signaling cascade. To this end, an Igfbp3-null mouse model was generated in combination with KrasG12D to compare the tumor burden. Then, IGF-dependent signaling was assessed after expressing wild-type or a mutant IGFBP3 without IGF binding capacity in non–small cell lung cancer (NSCLC) cells. Finally, the treatment response to CDDP chemotherapy was evaluated under conditions of IGFBP3 overexpression. Igfbp3-null mice had increased lung tumor burden (&gt;2-fold) and only half of human lung cancer cells survived after expression of IGFBP3, which corresponded to increased cleaved caspase-3 (10-fold), inactivation of IGF1 and MAPK signaling. In addition, overexpression of IGFBP3 increased susceptibility to CDDP treatment in lung cancer cells. These results, for the first time, demonstrate that IGFBP3 mediates lung cancer progression in a KrasG12D mouse model. Furthermore, overexpression of IGFBP3 induced apoptosis and enhanced cisplatin response in vitro and confirmed that the suppression is in part by blocking IGF1 signaling.
Implications: These findings reveal that IGFBP3 is effective in lung cancer cells with high IGF1 signaling activity and imply that relevant biomarkers are essential in selecting lung cancer patients for IGF1-targeted therapy. Mol Cancer Res; 15(7); 896–904. ©2017 AACR.
Cessation of oral anticoagulation is an important risk factor for stroke and mortality in atrial fibrillation patients
Authors: Rivera-Caravaca José Miguel , Roldán Vanessa , Esteve-Pastor María Asunción , Valdés Mariano , Vicente Vicente , Lip Gregory Y. H. , Marín Francisco 
Published: March 2017

SummaryOral anticoagulation (OAC) is highly effective preventing stroke and mortality in AF, but withdrawal is common in the elderly, when high bleeding risk and when are difficulties achieving an optimal time in therapeutic range (TTR). We analysed the rate of OAC cessation, predisposing factors to cessation and the relation to clinical outcomes in a large ‘real world’ cohort of AF patients over a long follow-up period. Consecutive non-valvular AF outpatients clinically stables for six months were recruited. Rates of cardiovascular events, major bleeding and mortality were recorded and related to OAC cessation. We included 1361 patients (48.7 % male; aged 76, IQR 71–81), followed-up for a median of 6.5 years. During follow-up, 244 patients suffered thrombotic events, 250 suffered from major bleeding and 551 patients died. 10 % of patients stopped OAC. After OAC withdrawal, there were 36 thromboembolic events (22 strokes), 10 major bleedings and 75 deaths. OAC cessation was independently associated with adverse cardiovascular events (HR 1.45; 95 % CI 1.01–2.08), stroke/TIA (HR 1.85; 1.17–2.94) and all-cause mortality (HR 1.30; 1.02–1.67). Independent predictors of OAC cessation were age ≥80 (HR 2.29; 1.60–3.29), previous coronary artery disease (HR 0.32; 0.15–0.71), major bleeding (HR 5.00; 3.49–7.15), heart failure (HR 2.38; 1.26–4.47), cancer (HR 5.24; 3.25–8.44) and renal impairment developed during follow-up (HR 2.70; 1.26–5.75). In conclusion, in non-valvular AF patients, cessation of OAC was independently associated with the risk of stroke, adverse cardiovascular events and mortality. Bleeding events and some variables associated with higher bleeding risk are responsible for OAC cessation.Note: The review process for this manuscript was fully handled by Christian Weber, Editor in Chief.Supplementary Material to this article is available online at www.thrombosis-online.com.