bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avalanche dynamics by Newton. Reply to comments on avalanche flow models based on the concept of random kinetic energy
Authors: BARTELT PERRY , BUSER OTHMAR 
Published: January 2018

ABSTRACTThe critique by Issler and other (2017) of our avalanche dynamics model maintains that we disregard well-established results of particulate gravity flows. Here we show that the arguments of Issler and others (1) violate Newton's laws of motion in the avalanche core and (2) ignore size-dependent drag forces on snow particles (Stokes law) that lead to the formation of avalanche suspension layers. We explain why we cannot amend our model equations to accommodate their suggestions. The goal of our approach is to describe highly non-stationary processes in the avalanche core that lead to a wide range of avalanche flow types and therefore different flow behavior. This is important for practical applications.
INTENSIFICATION BENEFIT INDEX: HOW MUCH CAN RURAL HOUSEHOLDS BENEFIT FROM AGRICULTURAL INTENSIFICATION?
Authors: HARRIS D. 
Published: January 2018

SUMMARYSustainable intensification (SI) of agriculture is the predominant objective for agricultural research and extension worldwide. Researchers and policymakers consider SI to be essential to avoid global hunger, improve human nutrition and reduce rural poverty while avoiding all manner of environmental disasters. To achieve these global public goods requires a large number of rural households – ‘small farmers’ – in less developed countries to improve their agriculture. Household size and farm size from 11,789 households in 15 countries from sub-Saharan Africa were used to calculate an intensification benefit index (IBI) that reflects how much a household will benefit if intensification occurs. IBI is defined as the increase in personal daily income (cents/person/day) as returns to land (dollars/hectare/year) increase. Actual net farm income from 160 rural households in each of three countries was compared with their IBI values to explore the gap between potential intensification and current smallholder farm performance. Fifty percent of all households had IBI values less than 0.075 cents/dollar, 70% less than 0.125 cents/dollar and 90% less than 0.225 cents/dollar. Returns of $1000/ha/year would result in fewer than 15% of households crossing a $2/person/day poverty line; $2500/ha/year would be required to lift 50% of the sample above the line; and even with $4000/ha/year, more than 30% of households would remain below the line. Since mean net returns from three sub-sampled sites were only $78, $83 and $424/ha/year the gap between potential- and actual performance is large but, theoretically, amenable to closure through adoption of improved technologies. However, surveys have shown that the available technologies would struggle to bridge the gap completely for rural households with small farms. For many small farms, the gains from adopting improved technologies are unlikely by themselves to lift them out of poverty and so might not be as attractive as scientists would wish.
Tabligh Jama‘at in China: Sacred self, worldly nation, transnational imaginary
Authors: STEWART ALEXANDER 
Published: January 2018

AbstractThis article will evaluate how the experience of participating in the Tabligh Jama‘at affects the formation of Chinese Muslims’ subjectivities in relation to their local, national, and global communities by using data gleaned from interviews with participants in the movement and participation in Tabligh activities in and around Xining, Qinghai Province. Intensively structured practices make the movement seem restrictive, but observing the variety permitted in individual performances and autonomy allowed by grassroots governance reveals that the movement imbues participants with a high degree of agency. A sense of belonging in a pious transnational community grants individuals the means and confidence to reshape their everyday behaviours and comportment in a way that transcends traditional sectarian structures of authority and conflicts with the predominant materialism of modern China. The movement's inward focus and apolitical stance make the movement a subtle and peaceful means of tacitly undermining both atheist state and Muslim hierarchies, reinventing oneself, and expressing membership in the global ummah.
Low-temperature plasmas induced in nitrogen by extreme ultraviolet (EUV) pulses
Authors: Bartnik A. , Skrzeczanowski W. , Fiedorowicz H. , Wachulak P. , Fok T. 
Published: January 2018

AbstractIn this work, a comparative study of low-temperature plasmas, induced in a gaseous nitrogen by photoionization of the gas using two different irradiation systems, was performed. Both systems were based on laser-produced Xe plasmas, emitting intense extreme ultraviolet (EUV) radiation pulses in a wide wavelength range. The essential difference between the systems concerned formation of the EUV beam. The first one utilized a dedicated ellipsoidal mirror for collecting and focusing of the EUV radiation. This way a high radiation fluence could be obtained for ionization of the N2 gas injected into the vacuum chamber. The second system did not contain any EUV collector. In this case, the nitrogen to be ionized was injected into the vicinity of the Xe plasma. In both cases, energies of emitted photons were sufficient for dissociative ionization, ionization of atoms or even ions. The resulting photoelectrons had also sufficiently high energy for further ionizations or excitations. Low-temperature plasmas, created this way, were investigated by spectral measurements in the EUV, ultraviolet (UV) and visible (VIS) spectral ranges. Time-resolved UV/VIS spectra, corresponding to single-charged ions, molecules, and molecular ions, were recorded. Numerical simulations of the molecular spectra were performed allowing one to estimate vibrational and rotational temperatures of plasmas created using both irradiation systems.
Kinematic calibration of serial manipulators using Bayesian inference
Authors: Shammas Elie , Najjar Shadi 
Published: January 2018

SUMMARYIn this paper, a new calibration method for open-chain robotic arms is developed. By incorporating both prior parameter information and artifact measurement data, and by taking recourse to Bayesian inference methods, not only are the robot kinematic parameters updated but also confidence bounds are computed for all measurement data. In other words, for future measurement data not only the most likely end-effector configuration is estimated but also the uncertainty represented as 95% confidence bounds of that pose is computed. To validate the proposed calibration method, a three degree-of-freedom robotic arm was designed, constructed, and calibrated using both typical regression methods and the proposed calibration method. The results of an extensive set of experiments are presented to gauge the accuracy and utility of the proposed calibration method.
Virtual world anonymity and foreign language oral interaction
Authors: Melchor-Couto Sabela 
Published: January 2018

AbstractIn recent years, a considerably high number of research studies have looked into the use of virtual worlds (VWs) for language learning. A number of authors have hypothesised about the effects of anonymity when foreign language interactions are conducted via VWs. This study addresses the effect that the anonymity experienced in VW interaction may have on participants that present different affective profiles. The participants are 18 students (five male, 13 female) aged between 19 and 20 years old and registered in a Spanish undergraduate degree at the University of Roehampton (London). They were involved in four tandem oral interaction activities in the VW Second Life with a group of native Spanish students from the Universidad de Cádiz (Spain). A mixed-methods research design with quantitative and qualitative data was applied. Data were collected about the participants’ foreign language anxiety (FLA) levels, self-efficacy beliefs, and psychological profile (introvert/extrovert). Participants were also asked to answer three open-ended questions about how they felt during the interaction in the VW. The results obtained reveal a strong relationship between self-efficacy beliefs and the anonymity effect experienced by students, although no correlation was found between the participants’ FLA levels or personality profiles and their experience of the anonymity afforded by the VW.
Effect of simulated flooding during rice seed development and maturation on subsequent seed quality
Authors: Tejakhod Sujittra , Ellis Richard H. 
Published: January 2018

AbstractThe resilience of seed quality in rice (Oryza sativaL.) to flooding was investigated. Pot-grown plants of thejaponicacv. Gleva, theindicacv. IR64, and the introgressed line IR64-Sub1 were submerged in water, to simulate flooding, for 3‒5 days at different stages of seed development and maturation. Mean seed weight, pre-harvest sprouting, ability to germinate, and subsequent longevity in air-dry storage were assessed. Whereas seed quality in both IR64 and IR64-Sub1 was resilient to submergence, in Gleva the longer the duration of submergence and the later in development when plants were submerged the greater the pre-harvest sprouting. Thousand seed dry weight was reduced more by submergence in Gleva than IR64 or IR64-Sub1. At harvest maturity, few pre-harvest sprouted seeds were able to germinate upon rehydration after desiccation to 11‒12% moisture content. Seed longevity of the non-sprouted seed fraction in air-dry hermetic storage (40°C, 15% moisture content) was not affected greatly by submergence, but longevity of thejaponicarice was less than that of theindicarices due to the former's steeper seed survival curves. Longevity of the twoindicarices was predicted well by the seed viability equation and previously published estimates of viability constants for rice. The greater dormancy of IR64 and IR64-Sub1, compared with Gleva, enhanced resilience to pre-harvest sprouting and reduced thousand seed dry weight from plant submergence. There was little or no effect of plant submergence on subsequent air-dry storage longevity of non-sprouted seeds in any genotype.
Priming effects on seed germination of two perennial herb species in a disturbed lava field in central Mexico
Authors: Belmont Jafet , Sánchez-Coronado María E. , Osuna-Fernández Helia R. , Orozco-Segovia Alma , Pisanty Irene 
Published: January 2018

AbstractPriming has proved to enhance seed germination, but most of the research dealing with this topic has been carried out with cultivated species. The potential applications that this process has on wild species, which can be useful for restoration, are usually overlooked. This study analyses the germination response after natural priming and hydropriming ofPenstemon roseusandCastilleja tenuiflora, two perennial herbs growing in a protected area known as ‘Parque Ecológico de la Ciudad de México’. Photoblastism was evaluated for both species. Seeds were exposed to a hydration/dehydration cycle and then placed in germination chambers to determine responses to hydropriming. To identify the effects of natural priming, seeds were buried in natural conditions and then recovered every two months and placed in germination chambers. Germination percentages and rates were then quantified. Both species proved to have permeable seed coats.Penstemon roseusseeds are positive photoblastic whereasC. tenuifloraseeds are indifferent to light. Priming methods increasedC. tenuifloragermination rates, but they did not affect germination capacity. ForP. roseus, priming methods did not improve germination rates, and germination capacity of recovered seeds decreased after the rainy season, suggesting thatP. roseusforms a short-term, transient, seed bank. The germination strategies of these two species allow them to occupy suitable microsites for germination and establishment. These responses can be helpful in developing restoration programmes based on the accelerated establishment of native and characteristic successional species.
Supplementary physicians’ fees: a sustainable system?
Authors: Calcoen Piet , van de Ven Wynand P. M. M. 
Published: January 2018

AbstractIn Belgium and France, physicians can charge a supplementary fee on top of the tariff set by the mandatory basic health insurance scheme. In both countries, the supplementary fee system is under pressure because of financial sustainability concerns and a lack of added value for the patient. Expenditure on supplementary fees is increasing much faster than total health expenditure. So far, measures taken to curb this trend have not been successful. For certain categories of physicians, supplementary fees represent one-third of total income. For patients, however, the added value of supplementary fees is not that clear. Supplementary fees can buy comfort and access to physicians who refuse to treat patients who are not willing to pay supplementary fees. Perceived quality of care plays an important role in patients’ willingness to pay supplementary fees. Today, there is no evidence that physicians who charge supplementary fees provide better quality of care than physicians who do not. However, linking supplementary fees to objectively proven quality of care and limiting access to top quality care to patients able and willing to pay supplementary fees might not be socially acceptable in many countries. Our conclusion is that supplementary physicians’ fees are not sustainable.
Visualizing Music in the Silent Era: The Collaborative Experiments of Visual Symphony Productions
Authors: SIMONSON MARY 
Published: January 2018

AbstractIn July 1922, theNew York Timesreported that the “encouraging little film”Danse Macabrewas screening at the Rialto Theater in New York City. Directed by filmmaker Dudley Murphy, it starred dancers Adolph Bolm and Ruth Page in a visual interpretation of Saint-Saëns'sDanse Macabrethat synchronized perfectly with live performances of the composition. While film scholars have occasionally citedDanse Macabreand Murphy's other shorts from this period as examples of early avant-garde filmmaking in the United States, discussions of the films are mired in misunderstanding. In this article, I use advertisements, reviews, and other archival materials to trace the production, exhibition, and reception of Murphy's Visual Symphony project. These films, I argue, were not Murphy's alone: rather, they were a collaborative endeavor guided as heavily by musician and film exhibitor Hugo Riesenfeld as by Murphy himself. Recast in this way, the Visual Symphony project highlights evolving approaches to sound–image synchronization in the 1920s, the centrality of theater conductors and musicians to filmmaking in this period, and the various ways in which filmmakers, performers, and exhibitors conceptualized the relationship between music and film, and the live and the mediated, in the final decade of the silent era.
Defining the role of the tumor vasculature in antitumor immunity and immunotherapy
Authors: Schaaf Marco B. , Garg Abhishek D. , Agostinis Patrizia 
Published: January 2018

AbstractIt is now well established that cancer cells co-exist within a complex environment with stromal cells and depend for their growth and dissemination on tight and plastic interactions with components of the tumor microenvironment (TME). Cancer cells incite the formation of new blood and lymphatic vessels from preexisting vessels to cope with their high nutrient/oxygen demand and favor tumor outgrowth. Research over the past decades has highlighted the crucial role played by tumor-associated blood and lymphatic vasculature in supporting immunoevasion and in subverting T-cell-mediated immunosurveillance, which are the main hallmarks of cancers. The structurally and functionally aberrant tumor vasculature contributes to the protumorigenic and immunosuppressive TME by maintaining a cancer cell’s permissive environment characterized by hypoxia, acidosis, and high interstitial pressure, while simultaneously generating a physical barrier to T cells' infiltration. Recent research moreover has shown that blood endothelial cells forming the tumor vessels can actively suppress the recruitment, adhesion, and activity of T cells. Likewise, during tumorigenesis the lymphatic vasculature undergoes dramatic remodeling that facilitates metastatic spreading of cancer cells and immunosuppression. Beyond carcinogenesis, the erratic tumor vasculature has been recently implicated in mechanisms of therapy resistance, including those limiting the efficacy of clinically approved immunotherapies, such as immune checkpoint blockers and adoptive T-cell transfer. In this review, we discuss emerging evidence highlighting the major role played by tumor-associated blood and lymphatic vasculature in thwarting immunosurveillance mechanisms and antitumor immunity. Moreover, we also discuss novel therapeutic approaches targeting the tumor vasculature and their potential to help overcoming immunotherapy resistance.
Cell death-based treatment of childhood cancer
Authors: Westhoff Mike-Andrew , Marschall Nicolas , Grunert Michael , Karpel-Massler Georg , Burdach Stefan , Debatin Klaus-Michael 
Published: January 2018

AbstractAny therapy that aims at eradicating a cancerous growth will have at its core a cell death-inducing component. Here we argue that paediatric oncology presents with its unique set of considerations and problems, which—while taking the lead from oncological research experiences obtained from the adult population—need to be clinically evaluated independently. This is particularly true when considering long-term side effects. Precision medicine offers a promising new approach in therapy, but given as a monotherapy and in a limited combination, as found in an apoptosis inducer/sensitiser combination, it will most likely lead to mutation escape of the target cell population and the emergence of resistance. However, using the increasing amount of the molecular data as the basis for a complex combination therapy combining several key components such as cell death-inducing agents, kinase inhibitors and BH3 mimetics, holds great promise.
Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration
Authors: Ising Christina , Heneka Michael T. 
Published: January 2018

AbstractOver the past decades, our view on neurodegenerative diseases has been mainly centered around neurons and their networks. Only recently it became evident that immunological processes arise alongside degenerating neurons, raising the question whether these represent just meaningless bystander reactions or in turn, contribute to pathogenesis and disease symptoms. When considering any effect of inflammatory events on the CNS one has to consider the site, duration and nature of immune activation. Likewise, one has to distinguish between mechanisms which directly impact the neuronal compartment and indirect mechanisms, which affect cells that are important for neuronal functioning and survival. As discussed in this review, both types of mechanisms may be present at the same time and additively or synergistically lead to neuronal demise. Inflammatory mediators released by the principle innate immune cells of the brain, microglia and astrocytes, can compromise the function and structure of neurons, thereby playing important roles in the pathogenesis of neurodegenerative diseases.
Practical device-independent quantum cryptography via entropy accumulation
Authors: Arnon-Friedman Rotem , Dupuis Frédéric , Fawzi Omar , Renner Renato , Vidick Thomas 
Published: January 2018

AbstractDevice-independent cryptography goes beyond conventional quantum cryptography by providing security that holds independently of the quality of the underlying physical devices. Device-independent protocols are based on the quantum phenomena of non-locality and the violation of Bell inequalities. This high level of security could so far only be established under conditions which are not achievable experimentally. Here we present a property of entropy, termed “entropy accumulation”, which asserts that the total amount of entropy of a large system is the sum of its parts. We use this property to prove the security of cryptographic protocols, including device-independent quantum key distribution, while achieving essentially optimal parameters. Recent experimental progress, which enabled loophole-free Bell tests, suggests that the achieved parameters are technologically accessible. Our work hence provides the theoretical groundwork for experimental demonstrations of device-independent cryptography.
A naturally occurring epiallele associates with leaf senescence and local climate adaptation in Arabidopsis accessions
Authors: He Li , Wu Wenwu , Zinta Gaurav , Yang Lan , Wang Dong , Liu Renyi , Zhang Huiming , Zheng Zhimin , Huang Huan , Zhang Qingzhu , Zhu Jian-Kang 
Published: January 2018

AbstractEpigenetic variation has been proposed to facilitate adaptation to changing environments, but evidence that natural epialleles contribute to adaptive evolution has been lacking. Here we identify a retrotransposon, named “NMR19” (naturally occurring DNA methylation variation region 19), whose methylation and genomic location vary amongArabidopsis thalianaaccessions. We classify NMR19 as NMR19-4 and NMR19-16 based on its location, and uncover NMR19-4 as an epiallele that controls leaf senescence by regulating the expression ofPHEOPHYTIN PHEOPHORBIDE HYDROLASE(PPH). We find that the DNA methylation status of NMR19-4 is stably inherited and independent of genetic variation. In addition, further analysis indicates that DNA methylation of NMR19-4 correlates with local climates, implying that NMR19-4 is an environmentally associated epiallele. In summary, we discover a novel epiallele, and provide mechanistic insights into its origin and potential function in local climate adaptation.
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
Authors: Hsieh Wan-Chen , Hsu Tzu-Sheng , Chang Ya-Jen , Lai Ming-Zong 
Published: January 2018

AbstractX-linked lymphoproliferative syndrome type-2 (XLP-2) is a primary immunodeficiency disease attributed to XIAP mutation and is triggered by infection. Here, we show that mouse Xiap−/− regulatory T (Treg) cells and human XIAP-deficient Treg cells are defective in suppressive function. The Xiap−/− Treg cell defect is linked partly to decreased SOCS1 expression. XIAP binds SOCS1 and promotes SOCS1 stabilization. Foxp3 stability is reduced in Xiap−/− Treg cells. In addition, Xiap−/− Treg cells are prone to IFN-γ secretion. Transfer of wild-type Treg cells partly rescues infection-induced inflammation in Xiap−/− mice. Notably, inflammation-induced reprogramming of Xiap−/− Treg cells can be prevented by blockade of the IL-6 receptor (IL-6R), and a combination of anti-IL-6R and Xiap−/− Treg cells confers survival to inflammatory infection in Xiap−/− mice. Our results suggest that XLP-2 can be corrected by combination treatment with autologous iTreg (induced Treg) cells and anti-IL-6R antibody, bypassing the necessity to transduce Treg cells with XIAP.