bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volumetric Hydrogen Storage Capacity in Metal–Organic Frameworks
Authors: Balderas‐Xicohténcatl R. , Schlichtenmayer Maurice , Hirscher Michael 
Published: November 2017

AbstractMolecular hydrogen storage in metal–organic frameworks (MOFs) is one possibility for on‐board storage in fuel‐cell vehicles, but so far generally only the gravimetric hydrogen storage capacity has been considered. Here we analyze the volumetric absolute hydrogen uptake of many MOFs measured at 77 K and 2.0–2.5 MPa in our laboratory in recent years and correlate these to their structure. A linear relation is found for the volumetric absolute hydrogen uptake as a function of the volumetric surface area, which yields the same hydrogen surface density as in Chahine's rule. Furthermore, the experimental data show a correlation between the specific volume and the specific surface area, which is used to develop a phenomenological model for the volumetric absolute uptake as a function of the gravimetric absolute uptake. Most of the MOFs follow this relation. However, the interpenetrated framework, CFA‐7, shows the strongest deviation and the highest volumetric absolute hydrogen storage capacity at 77 K and 2.0 MPa.
Recent Progress in Solution‐Processed Copper‐Chalcogenide Thin‐Film Solar Cells
Authors: Li Wenjie , Tan Joel Ming Rui , Leow Shin Woei , Lie Stener , Magdassi Shlomo , Wong Lydia Helena 
Published: November 2017

AbstractSolution‐based thin‐film semiconductors offer a promising path for the mass production of low‐cost solar cells prepared at low temperatures. Thin‐film Cu‐based chalcogenides such as Cu(In,Ga)(S,Se)2 (CIGSSe) and Cu2ZnSn(S,Se)4 (CZTSSe) hold great promise and have been regarded as viable candidates because of the abundance of their constituent elements and environmentally nontoxic nature. This Review summarizes the recent progress in solution‐processed Cu chalcogenides (CuInSe2, Cu(In,Ga)(S,Se)2, Cu2ZnSnS4, Cu2ZnSn(S,Se)4) for thin‐film solar cells, with emphasis on the precursor solution deposited by spray pyrolysis and spin coating. The general aspects, current status, and recent research highlights are introduced and analyzed in detail. Finally, the challenges and future prospects of these solar cells are also discussed.
Early‐onset epileptic encephalopathy and severe developmental delay in an association with de novo double mutations in NF1 and MAGEL2
Authors: Akamine Satoshi , Sagata Noriaki , Sakai Yasunari , Kato Takahiro A. , Nakahara Takeshi , Matsushita Yuki , Togao Osamu , Hiwatashi Akio , Sanefuji Masafumi , Ishizaki Yoshito , Torisu Hiroyuki , Saitsu Hirotomo , Matsumoto Naomichi , Hara Toshiro , Sawa Akira , Kano Shinichi , Furue Masutaka , Kanba Shigenobu , Shaw Chad A. , Ohga Shouichi 
Published: November 2017

SummaryAdvance in the exome‐wide sequencing analysis contributes to identifying hundreds of genes that are associated with early‐onset epileptic encephalopathy and neurodevelopmental disorders. On the basis of massive sequencing data, functional interactions among different genes are suggested to explain the common molecular pathway underlying the pathogenic process of these disorders. However, the relevance of such interactions with the phenotypic severity or variety in an affected individual remains elusive. In this report, we present a 45‐year‐old woman with neurofibromatosis type 1 (NF1), infantile‐onset epileptic encephalopathy, and severe developmental delay. Whole‐exome sequencing identified de novo pathogenic mutations in NF1 and the Schaaf‐Yang syndrome‐associated gene, MAGEL2. Literature‐curated interaction data predicted that NF1 and MAGEL2 proteins were closely connected in this network via their common interacting proteins. Direct conversion of fibroblasts into neurons in vitro showed that neuronal cells from 9 patients with NF1 expressed significantly lower levels of MAGEL2 (54%, p = 0.0047) than those from healthy individuals. These data provide the first evidence that pathogenic mutations of NF1 deregulate the expression of other neurodevelopmental disease‐associated genes. De novo mutations in multiple genes may lead to severe developmental phenotypes through their cumulative effects or synergistic interactions.
Periphyton and abiotic factors influencing arsenic speciation in aquatic environments
Authors: Lopez Adeline R. , Silva Silmara Costa , Webb Samuel M. , Hesterberg Dean , Buchwalter David B. 
Published: November 2017

Abstract

Benthic periphytic biofilms are important food sources at the base of aquatic ecosystems. These biofilms also sit at the interface of oxic waters and hypoxic sediments, and can be influenced by or influence trace element speciation. In the present study, we compared arsenic (As) enrichment in periphyton exposed to arsenate (As[V]) or arsenite (As[III]) (20 μg/L, static renewal, 7 d), and we found similar accumulation patterns of total As (101 ± 27 and 88 ± 22 mg kg−1 dry wt, respectively). Periphyton As was 6281- and 6684-fold higher than their aqueous exposures and occurred primarily as As(V). When these biofilms were fed to larval mayflies, similar total As tissue concentrations (13.9 and 14.6 mg kg−1 dry wt, respectively) were observed, revealing significant biodilution (∼ 10% of their dietary concentrations). Finally, we investigated the influence of aeration and periphyton presence on As speciation in solutions and solid phases treated with As(III). Predominantly As(III) solutions were slowly oxidized over a 7-d time period, in the absence of periphyton, and aeration did not strongly affect oxidation rates. However, in the presence of periphyton, solution and solid-phase analyses (by microscale x-ray absorption spectroscopy) showed rapid As(III) oxidation to As(V) and an increasing proportion of organo-As forming over time. Thus periphyton plays several roles in As environmental behavior: 1) decreasing total dissolved As concentrations via abiotic and biotic accumulation, 2) rapidly oxidizing As(III) to As(V), 3) effluxing organo-As forms into solution, and 4) limiting trophic transfer to aquatic grazers. Environ Toxicol Chem 2018;37:903–913. © 2017 SETAC
Synthesis, Characterization, and Photonic Efficiency of Novel Photocatalytic Niobium Oxide Materials
Authors: Morais Lidiane A. , Adán Cristina , Araujo Antonio S. , Guedes Ana P. M. A. , Marugán Javier 
Published: November 2017

AbstractThe application of niobium oxides as photocatalytic materials for the removal of contaminants is scarcely reported in the literature. This work reports the methodology to synthesize four different mesoporous niobium oxide materials and the correlation between the physicochemical properties and the photocatalytic activity. X‐ray diffraction, UV–vis diffuse reflectance spectra (DRS), transmission electron microscopy, and nitrogen adsorption techniques are used to characterize the structure and composition of the obtained materials. The photocatalytic oxidation of methanol is used as reaction test to assess the photocatalytic activities and photonic efficiencies of the materials as a function of the catalyst concentration. Nb2O5 materials display lower reaction rates, which can be attributed to the relatively high average particle size. By contrast, NaNbO3 materials show higher activity, especially for high catalyst loading. No significant differences in absorption and scattering of light are observed among the materials, indicating that the higher photonic efficiency of NaNbO3 should be the result of a lower charge recombination derived from its microstructure, sodium composition, low particle size, and high specific surface area of these materials.
Archaeological prospection of the nearshore and intertidal area using ultra‐high resolution marine acoustic techniques: Results from a test study on the Belgian coast at Ostend‐Raversijde
Authors: Missiaen Tine , Evangelinos Dimitris , Claerhout Chloe , De Clercq Maikel , Pieters Marnix , Demerre Ine 
Published: November 2017

AbstractThe coastal site of Ostend‐Raversijde in Belgium is known for its archaeological artifacts, mainly from Roman and medieval times. In recent years, detailed geophysical and geotechnical investigations have been carried out here to test the efficiency of these techniques for geoarchaeological prospection of the subtidal and intertidal zone. Very high‐resolution 2D subbottom profiling using a parametric echosounder evidenced a highly complex system of paleogullies and tidal channels, some of which can be linked to the medieval peninsulaTesterepand the drowned settlement ofWalraversijde. For the first time marine seismic and terrestrial electromagnetic induction (EMI) data were fully integrated in the same intertidal area. The parametric echosounder proved a highly effective tool to map the (partly excavated) peat layers and submerged landscape in high detail, even in extremely shallow water. Using a novel multitransducer parametric echosounder (SES‐2000 Quattro), unique 3D imaging of the peat exploitation pattern was possible with unprecedented detail (submeter level). This sets a new standard for shallow water research and opens important new perspectives for geoarchaeological studies in nearshore areas.
Disparities in rate, triggers, and management in pediatric and adult cases of suspected drug‐induced anaphylaxis in Canada
Authors: Gabrielli Sofianne , Clarke Ann E. , Eisman Harley , Morris Judy , Joseph Lawrence , La Vieille Sebastien , Small Peter , Lim Rodrick , Enarson Paul , Zelcer Michal , Chan Edmond S. , Mill Chris , Ben‐Shoshan Moshe 
Published: November 2017

AbstractIntroductionData is sparse on drug‐induced anaphylaxis (DIA) and there have not been studies assessing the differences in clinical characteristics and management of DIA between adults and children.ObjectiveWe assessed the percentage, diagnosis, and management of DIA among all anaphylaxis visits in three pediatric and one adult emergency departments (ED) across Canada.MethodsChildren presenting to the Montreal Children's Hospital (MCH), British Columbia Children's Hospital (BCCH), and Children's Hospital at London Health Sciences Center and adults presenting to Hôpital du Sacré‐Coeur with anaphylaxis were recruited as part of the Cross‐Canada Anaphylaxis Registry. A standardized data form documenting the reaction and management was completed and patients were followed annually to determine assessment by allergist and use of confirmatory tests.ResultsFrom June 2012 to May 2016, 51 children were recruited from the pediatric centers and 64 adults from the adult center with drug‐induced anaphyalxis. More than half the cases were prospectively recruited. The percentage of DIA among all cases of anaphylaxis was similar in all three pediatric centers but higher in the adult center in Montreal. Most reactions in children were triggered by non‐antibiotic drugs, and in adults, by antibiotics. The majority of adults and a third of children did not see an allergist after the initial reaction. In those that did see an allergist, diagnosis was established by either a skin test or an oral challenge in less than 20% of cases.ConclusionsOur results reveal disparities in rate, culprit, and management of DIA in children versus adults. Further, most cases of suspected drug allergy are not appropriately diagnosed. Guidelines to improve assessment and diagnosis of DIA are required.
Stimuli‐responsive Supra‐biomolecular Nanoassemblies of Cucurbit[7]uril with Bovine Serum Albumin: Drug Delivery and Sensor Applications
Authors: Barooah Nilotpal , Khurana Raman , Bhasikuttan Achikanath C. , Mohanty Jyotirmayee 
Published: November 2017

AbstractConstruction and characterization of stimuli‐responsive supra‐biomolecular nanoassembly between cucurbit[7]uril (CB7) and bovine serum albumin (BSA), uptake and release of doxorubicin (DOX) in live cells, the enhanced sensitivity of brilliant green (BG) and the metal ion‐induced relocation of neutral red (NR) dye to BSA have been discussed in this review. The fluorescence intensity of DOX is largely quenched in the presence of nanoassembly which recovers with adamantylamine or by changing the pH of the solution, indicating the significant uptake and release of DOX. Whereas, the interaction of BG with CB7‐BSA assembly leads to a huge fluorescence enhancement ∼350‐fold through ternary complex formation. In another study, the supramolecular pKa tuning of nanoassembly encapsulated NR dye with metal ion and the consequent relocation of NR from CB7 cavity to the hydrophobic pocket of BSA have been demonstrated. All these studies show promising applications in drug delivery and on‐off sensor.
Let's Think Creatively: Designing a High School Lesson on Metaphorical Creativity for English L2 Learners
Authors: Wang Hung‐chun 
Published: November 2017

AbstractThis article reports on a practitioner research study exploring how creative thinking activities can be designed and integrated into high school English classes. It delineates the process of developing a metaphorical creativity workshop for year 11 students in Taiwan and demonstrates the students’ workshop experiences and learning outcomes. Results of the study reveal that the workshop stimulated the students’ metaphorical creativity and expanded their English‐language knowledge. Findings also suggest that the workshop can be further improved in several ways, such as including more diverse topics about language creativity and combining creativity training with textbook content. Overall, this study provides essential insights that can help English teachers design creative thinking activities and integrate them into high school English curricula effectively.
Low‐level perfluorooctanoic acid enhances 3 T3‐L1 preadipocyte differentiation via altering peroxisome proliferator activated receptor gamma expression and its promoter DNA methylation
Authors: Ma Yue , Yang Jie , Wan Yanjian , Peng Yang , Ding Shuai , Li Yuanyuan , Xu Bing , Chen Xi , Xia Wei , Ke Yuebin , Xu Shunqing 
Published: November 2017

AbstractRecent studies suggest that perfluorooctanoic acid (PFOA) can play a role in the development of obesity; however, the associated mechanisms are poorly understood. We investigated how PFOA exposure affected the differentiation of 3 T3‐L1 preadipocytes and the associated transcriptional and epigenetic mechanisms. Cells treated with different doses of PFOA (ranging from 0.01 to 100 μg ml–1) were assessed for proliferation, differentiation and triglyceride accumulation. The gene expression levels of peroxisome proliferator activated receptor gamma (PPARγ) and its target genes were measured. DNA methylation levels of PPARγ promoter and global DNA methylation levels were also tested. We found a concentration‐dependent enhancement of adipocyte proliferation and differentiation following PFOA exposure. PFOA also induced a significant concentration‐dependent increase in the accumulation of lipid and triglyceride. Increased gene expression was also observed for PPARγ, CCAAT/enhancer binding proteins α, fatty acid binding protein 2 and lipoprotein lipase in differentiated cells after PFOA exposure. The ability of PFOA to induce adipogenesis was blocked by GW9662, a known PPARγ antagonist. In addition, significant demethylation of the cytosine–phosphate–guanine sites in the PPARγ promoter was observed after exposure to PFOA. In addition, PFOA exposure resulted in decreased global DNA methylation and increased expression levels of DNA methyltransferases genes. We found that treatment with low levels of PFOA can induce adipogenic differentiation in preadipocytes, and the underlying mechanisms probably involve the activation of PPARγ transcription and demethylation of PPARγ promoter.
Trichostatin A alters cytoskeleton and energy metabolism of pancreatic adenocarcinoma cells: An in depth proteomic study
Authors: Dalla Pozza Elisa , Manfredi Marcello , Brandi Jessica , Buzzi Arianna , Conte Eleonora , Pacchiana Raffaella , Cecconi Daniela , Marengo Emilio , Donadelli Massimo 
Published: November 2017

AbstractPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal of all human cancers with a high mortality rate. Resistance to conventional treatments and chemotherapeutics is a typical feature of PDAC. To investigate the causes of drug resistance it is essential to deeply investigate the mechanism of action of chemotherapeutics. In this study, we performed an in depth shotgun proteomic approach using the label‐free proteomic SWATH‐MS analysis to investigate novel insights of the mechanism of action of the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) in PDAC cells. This proteomic analysis in PaCa44 cells and data elaboration of TSA‐regulated proteins by bioinformatics showed an overall up‐regulation of cytokeratins and other proteins related to the cytoskeleton organization, keratinization, and apoptotic cell death. On the contrary, a large amount of the down‐regulated proteins by TSA treatment belongs to the cellular energetic metabolism and to the machinery of protein synthesis, such as ribosomal proteins, determining synergistic cell growth inhibition by the combined treatment of TSA and the glycolytic inhibitor 2‐deoxy‐d‐glucose in a panel of PDAC cell lines. Data are available via ProteomeXchange with identifier PXD007801.
A case of retroperitoneal para‐aortic ectopic pregnancy detected by sonography
Authors: Zhang Min , Qin Ling‐Ling 
Published: November 2017

AbstractRetroperitoneal ectopic pregnancy is extremely rare. We present a case of a retroperitoneal ectopic pregnancy with a gestational sac located to the left of the abdominal aorta and of the left renal vessels at 9 weeks of gestation. Careful transabdominal sonographic examination is suggested when an ectopic pregnancy is suspected and the examination of the pelvis is negative.
Low‐intensity vibration increases cartilage thickness in obese mice
Authors: Pamon Tee , Bhandal Vincent , Adler Benjamin J. , Ete Chan M. , Rubin Clinton T. 
Published: November 2017

ABSTRACTObesity is associated with an elevated risk of osteoarthritis (OA). We examined here whether high fat diet administered in young mice, compromised the attainment of articular cartilage thickness. Further, we sought to determine if low‐intensity vibration (LIV) could protect the retention of articular cartilage in a mouse model of diet‐induced obesity. Five‐week‐old, male, C57BL/6 mice were separated into three groups (n = 10): Regular diet (RD), High fat diet (HF), and HF + LIV (HFv; 90 Hz, 0.2g, 30 min/d, 5 d/w) administered for 6 weeks. Additionally, an extended HF diet study was run for 6 months (LIV at 15 m/d). Articular cartilage and subchondral bone morphology, and sulfated GAG content were quantified using contrast agent enhanced μCT and histology. Gene expression within femoral condyles was quantified using real‐time polymerase chain reaction. Contrary to our hypothesis, HF cartilage thickness was not statistically different from RD. However, LIV increased cartilage thickness compared to HF, and the elevated thickness was maintained when diet and LIV were extended into adulthood. RT‐PCR analysis showed a reduction of aggrecan expression with high fat diet, while application of LIV reduced the expression of degradative MMP‐13. Further, long‐term HF diet resulted in subchondral bone thickening, compared to RD, providing early evidence of OA pathology—LIV suppressed the thickening, such that levels were not significantly different from RD. These data suggest that dynamic loading, via LIV, protected the retention of cartilage thickness, potentially resulting in joint surfaces better suited to endure the risks of elevated loading that parallel obesity. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:751–759, 2018.
Application of visible/near infrared spectroscopy to quality control of fresh fruits and vegetables in large‐scale mass distribution channels: a preliminary test on carrots and tomatoes
Authors: Beghi Roberto , Giovenzana Valentina , Tugnolo Alessio , Guidetti Riccardo 
Published: November 2017

AbstractBACKGROUNDThe market for fruits and vegetables is mainly controlled by the mass distribution channel (MDC). MDC buyers do not have useful instruments to rapidly evaluate the quality of the products. Decisions by the buyers are driven primarily by pricing strategies rather than product quality. Simple, rapid and easy‐to‐use methods for objectively evaluating the quality of postharvest products are needed. The present study aimed to use visible and near‐infrared (vis/NIR) spectroscopy to estimate some qualitative parameters of two low‐price products (carrots and tomatoes) of various brands, as well as evaluate the applicability of this technique for use in stores.RESULTSA non‐destructive optical system (vis/NIR spectrophotometer with a reflection probe, spectral range 450–1650 nm) was tested. The differences in quality among carrots and tomatoes purchased from 13 stores on various dates were examined. The reference quality parameters (firmness, water content, soluble solids content, pH and colour) were correlated with the spectral readings. The models derived from the optical data gave positive results, in particular for the prediction of the soluble solids content and the colour, with better results for tomatoes than for carrots.CONCLUSIONThe application of optical techniques may help MDC buyers to monitor the quality of postharvest products, leading to an effective optimization of the entire supply chain. © 2017 Society of Chemical Industry
Prognostic significance of the distribution of lymph node metastasis in rectal cancer after neoadjuvant chemoradiation
Authors: Lee Soo Young , Kim Chang Hyun , Kim Young Jin , Kim Hyeong Rok 
Published: November 2017

BackgroundThis study aimed to evaluate the prognostic significance of lymph node distribution (LND) in rectal cancer after neoadjuvant chemoradiation.MethodsA total of 519 patients with primary rectal cancer who underwent curative resection after neoadjuvant chemoradiation were included. LND was classified into four groups: LND0, no lymph node metastasis (368/519, 70.9%); LNDp, lymph node metastasis along the inferior mesenteric artery (proximal) (15/519, 2.9%); LNDm, lymph node metastasis at the mesorectum (109/519, 21.0%); and LNDpm, lymph node metastasis at both the proximal and mesorectal areas (27/519, 5.2%). Clinicopathologic characteristics were analyzed to identify independent prognostic factors.ResultsIn patients with positive lymph nodes, LND showed superior discrimination for 3‐year DFS (LNDp 67.7%, LNDm 48.9%, and LNDpm 26.8%, P = 0.003) and 3‐year LRFS (LNDp 93.3%, LNDm 81.4%, and LNDpm 60.5%, P = 0.009) compared to ypN stage (3‐year DFS, N1 47.8%, N2 40.0%, P = 0.184; 3‐year LRFS, N1 79.4%, N2 75.2%, P = 0.527). On multivariate survival analysis, LND was an independent prognostic factor for LRFS (P = 0.030) in patients with positive lymph nodes.ConclusionsLND may improve the prognostic value of the ypTNM staging system for patients with node‐positive rectal cancer after neoadjuvant chemoradiation, particularly in terms of local recurrence.