bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNA-Demethylating Agents enhance cytolytic activity of CD8+ T Cells and anti-tumor immunity
Authors: Yau Helen Loo , Chakravarthy Ankur , Almeida Felipe Campos de , Allard David , Singhania Rajat , Ettayebi Ilias , Shen Shu Yi , Medina Tiago , Mehdipour Parinaz , Morancho Beatriz , Pommey Sandra , Klein Christian , Amarante-Mendes Gustavo , Roulois David , Butler Marcus , Arribas Joaquín , Stagg John , De Carvalho Daniel D. 
Published: October 2017

AbstractRecent studies have shown that DNA methyltransferase inhibitors (DNMTi) can induce IRF7 activation and Type I/III interferon signaling through dsRNA-mediated viral mimicry in cancer cells. By performing a large pan-cancer analysis using TCGA data, we determined that IRF7 activation is associated with higher CD8+ T cell tumor infiltration and higher cytolytic activity across multiple cancer types. Accordingly, we demonstrate that DNMTi treatment results in increased CD8+ T cell tumor infiltration, enhanced cytolytic activity and CD8+ T cell dependent tumor growth inhibition. Finally, we show that DNMTi triggers a process marked by the induction of viral mimicry directly on CD8+ T cells, leading to activation of dsRNA sensing pathway, and up-regulation of T cell activation markers, effector cytokines, and Granzyme B. Taken together, our findings suggest that dsRNA sensing pathway activation in the immune compartment, through pharmacological DNA demethylation, is a viable strategy for boosting anti-tumor immune response.
Role of restaurant employees’ intrinsic motivations on knowledge management
Authors: Lee Seonjeong (Ally) , Kim Soon-Ho 
Published: October 2017

PurposeThis study aims to investigate the role of restaurant employees’ intrinsic motivations that influenced their knowledge-sharing behaviors and knowledge application behaviors, based on need theory and prior knowledge management research.Design/methodology/approachA cross-sectional, self-administered survey was used to collect data from employees who work in the food and beverage sections of hotels, coffee shops or restaurants.FindingsResults from this study supported the role of employees’ intrinsic motivations to share knowledge with other employees and apply their knowledge to actions. Moreover, results identified employees’ knowledge application behaviors that influenced their innovative behaviors.Originality/valueThis paper investigated the role of restaurant employees’ intrinsic motivations on their knowledge management and innovative behaviors.
Does paying higher franchise fees command higher RevPAR?
Authors: Hua Nan , O’Neill John W. , Nusair Khaldoon , Singh Dipendra , DeFranco Agnes 
Published: October 2017

PurposeThis study aims to validate the value-added hypothesis in hotel franchising using data from 2,120 properties across the United States with a total of 12,720 observations over a six-year period of 2008-2013.Design/methodology/approachA series of annual cross-sectional regressions for each of the sample years and aggregated panel regressions for all sample hotel years were conducted. Newey–West errors were computed to address potential issues of autocorrelation and heteroscedasticity, and sensitivity tests were also performed.FindingsThe paper concludes that franchise royalty fee adds value to hotel franchisees as it significantly and positively affects revenue per available room (RevPAR) for all sample years after controlling for the major determining dimensions of RevPAR. A series of sensitivity tests also show robustness of results.Research limitations/implicationsThis study offers a rational and empirical explanation for the positive and significant effect of franchise royalty fees on hotel performance and the value-added hypothesis. Hoteliers need to ensure that there is a proper match between hotel specific attributes and the potential franchise when making a franchise selection. Individual entrepreneurs can partner with franchisors to reap the benefits of franchising, while experienced hoteliers can also use the findings of this study to make strategic decisions.Originality/valueThis study is the first using actual performance data from a large hotel property sample over multiple years to validate the value-added theory, where a higher royalty fee does command a higher RevPAR.
Chinese hotel firm internationalisation: Jin Jiang’s joint venture acquisition
Authors: Gross Michael J. , Huang Songshan (Sam) , Ding Yi 
Published: October 2017

PurposeThe purpose of this study was to examine the characteristics of mainland Chinese hotel firm internationalisation relative to traditional Western internationalisation theory through an analysis of the Shanghai Jin Jiang International Hotels Group’s joint venture with the Thayer Lodging Group to acquire Interstate Hotels & Resorts.Design/methodology/approachThe case study method was used to examine the three firms involved in the joint venture acquisition. The technique of elite interviews was used to collect primary data. Semi-structured personal interviews were conducted with senior corporate executives who were engaged as principals with the conception, execution and administration of the joint venture. Content analysis was performed with the interview data, seeking themes and patterns consistent with the study purpose.FindingsThe findings demonstrated specific characteristics that distinguish the internationalisation that Jin Jiang has pursued. The five distinctive characteristics were as follows: a “leap” market entry mode, a pattern of “a small fish eats a big fish”, a preference for purchasing hotels in the West, capital sourcing from Chinese banks and strategic rather than operational control of the acquired firm.Research limitations/implicationsThe findings indicate both similarities and differences between the China context of hotel firm internationalisation and that of Western firms. Theoretical implications are examined through an analysis of Dunning’s OLI (ownership, location, internalisation) framework. Generalisability of empirical findings may be limited by the China context and the unique combination of three firms.Practical implicationsThe findings advance our understanding of the relationship between Chinese and Western practices, particularly in the approaches that firms take in internationalisation.Originality/valueThe story reported in this paper is about the first firm internationalisation endeavour in the mainland Chinese hotel industry. This is a landmark event for the international hospitality industry that will have historical significance, and represents the leading edge of mainland Chinese hotel firm cross-border expansion. This study contributes an early analysis of how the Chinese hotel sector may approach internationalisation.
Factors that influence hand hygiene practice amongst occupational therapy students
Authors: Wall Olivia M. , Smiddy Maura P. 
Published: October 2017

Purpose
Hand hygiene is the single most important intervention to reduce the risk of acquiring infection. All healthcare workers and healthcare students have a responsibility to prevent transmission of infection. The purpose of this study is to investigate students’ attitudes to hand hygiene following university-based education and practice placement. Students attended a lecture, completed an e-learning module, participated in a practical session using a ultra-violet light hand inspection cabinet and engaged in clinical placement.

Design/methodology/approach
In all, 64 students participated in a multimodal hand hygiene education programme before clinical placement, with each student completing an in-class questionnaire after placement. Data were analysed using descriptive and comparative statistics. Students rated educational methods that had most influence on them. Their preference was for a practical hand hygiene education session. Students were also influenced by the therapist they were on placement with. They were least influenced by the didactic college presentation.

Findings
This study highlights that students may be influenced by different methods of education at different stages in their course and that placement may be an important influencing factor in the earlier years of occupational therapy education.

Research limitations/implications
This study highlights the importance of the availability of a multimodal educational approach and clinical placement to promote increased compliance with hand hygiene amongst students.

Practical implications
University healthcare course curricula should include multimodal approaches to the education of hand hygiene. While hand hygiene e-learning modules are beneficial, they should be used in conjunction with a multimodal educational strategy that incorporates practical elements. The influence of the therapist on a students’ behaviour should be utilised to improve both student and professionals hand hygiene adherence.

Originality/value
Original piece of work that is not widely discussed in Occupational Therapy literature.
Taming cronyism!: the role of Public Private Dialogues
Authors: Sabry Mohamed Ismail 
Published: October 2017

PurposeThe purpose of this paper is to explore the effect of Public Private Dialogues (PPD) on cronyism accounting for various cultural and governance institutions.Design/methodology/approachIt proposes a number of hypotheses on: whether PPD characterized by high official representation and business representation, through mainly building trust, succeed in minimizing cronyism; whether certain cultural and governance institutions help PPD in achieving this; and in cultural settings which are originally inducing cronyism whether PPD help in minimizing cronyism. These are tested empirically using an ordinary least squares multivariate panel regression.FindingsHigh official representation and high business people’s participation in PPD were found to help in minimizing cronyism in different cultures. This is arguably attributed to building trust in cultures characterized by having low general trust and low trust in governments. Accountability and transparency are significantly assisting PPD in this regard. Yet, PPD do not always succeed in taming cronyism, and in particular in ethnic fractionalized societies and societies having high collective cultures.Research limitations/implicationsThe biggest challenge this research faced was estimating a proxy for PPD. Better data on business associations’ participation worldwide are needed to construct a more developed proxy.Practical implicationsPPD with high business participation and government representation should be encouraged. The same is true for reform leading to higher levels of transparency and accountability.Originality/valueConstructing a proxy for PPD that allowed meta-analysis; and investigating theoretically and empirically the effect of the interaction of PPD with various institutions on cronyism.
The effects of microfinance on women’s empowerment: new evidence from Bangladesh
Authors: Rahman Mohammad Mafizur , Khanam Rasheda , Nghiem Son 
Published: October 2017

Purpose
The purpose of this paper is to examine the effects of microcredit on women’s empowerment in rural Bangladesh using the latest primary data.

Design/methodology/approach
Primary data have been collected by a household survey in the four districts of Bangladesh. Logistic regression is used to estimate the odd of improving women empowerment after participating in microfinance.

Findings
The results show positive impacts of microfinance on most of the selected indicators for women’s empowerment.

Research limitations/implications
Lack of control groups and baseline data are the main limitation of this research. Future research can address this issue by selecting institutions with baseline data or control groups.

Practical implications
The findings of the study can help policy makers to adopt appropriate policies that integrate empowerment in development projects with women.

Social implications
The results of this research could encourage more women to participate in microfinance activities and development projects.

Originality/value
This research provides the most updated data from a primary survey in Bangladesh. The authors also mitigate the possible selection biases by using a fixed-effects estimator.
Islamic vs conventional Human Development Index: empirical evidence from ten Muslim countries
Authors: Aydin Necati 
Published: October 2017

PurposeGiven the fact that the Islamic economic paradigm differs from the secular capitalist paradigm in terms of its emphasis on morality and spirituality, the author thinks that the current Human Development Index (HDI) does not capture human development from an Islamic perspective. The purpose of this paper is twofold: first, to provide a paradigmatic, theoretical, and conceptual model for the suggested Islamic HDI (iHDI) and second, to present several proxy variables for multi-dimensional iHDI and test the proposed index through empirical data for ten Muslim countries.Design/methodology/approachThe author developed eight-dimensional composite iHDIs based on the understanding of human nature from the Tawhidi anthropology. These dimensions included physical, reasoning, spiritual, ethical, animal, social, deciding, and oppressive selves. The author measured them using nine different indices, three of which came from the conventional HDI (cHDI). The author then compared the rankings of those Muslim countries in iHDI to those in cHDI.FindingsThe iHDI rankings for all Muslim countries except two differed from those in cHDI. The difference was more substantial for countries with higher economic development. Thus, improved cHDI rankings for Muslim countries based on their economic development do not necessarily mean that they move toward ideal human development. This finding confirms the need for an alternative human development indexing approach from an Islamic perspective.Research limitations/implicationsThe paper is likely to initiate movement to develop an alternative HDI from Islamic perspective.Practical implicationsThe paper findings have important policy implications for Muslim countries.Originality/valueIt is the first empirical paper showing how to develop an alternative HDI from an Islamic perspective.
Income shocks, informal insurance mechanisms, and household consumption expenditure
Authors: Ajefu Joseph Boniface 
Published: October 2017

Purpose
The purpose of this paper is to examine the effect of income shocks on household real consumption expenditure, taking into account the various informal coping strategies adopted by the households. Using Nigerian Household Panel Survey data for the year 2010/2011 and 2012/2013 respectively, and probit model estimation approach, the results suggest that idiosyncratic shocks have effect on household consumption expenditure and the informal insurance strategies play only limited roles in providing the needed insurance to households in the face of shocks. Also, the effect of shocks vary according to households characteristics, which depends on whether the household is headed by male or female and urban or rural dweller.

Design/methodology/approach
This paper explores the fixed effects and probit model estimation approach to examine the relationship between the effect of covariate and self-reported idiosyncratic shocks on household welfare. The study examines the effectiveness of the various informal coping measures adopted by households against shocks.

Findings
The results suggest that idiosyncratic shocks have been found to have little effect on real consumption expenditure and the informal insurance strategies play only limited roles in providing the much needed insurance to households in the face of shocks. Also, the effect of shocks vary according to households characteristics, whether the household is headed by male or female and urban or rural dweller is important.

Originality/value
The novelty of this essay is to investigate the relationship between variation in self-reported shocks to income across households and real consumption expenditure in Nigeria – a poor, risk-prone country – considering also, the ease with which households adopt the various risk-coping strategies, which help them in smoothing consumption over time.
The challenges facing poverty alleviation and financial inclusion in North-East Kenya Province (NEKP)
Authors: Ali Abd elrhman Elzahi Saaid 
Published: October 2017

Purpose
Poverty alleviation is one of the most compelling challenges facing Kenya today. It is not only widespread but it is also steadily rising. This highlights the need for sustainable solutions to poverty particularly through microfinance. This research investigated the case of North Eastern Kenya Province. The purpose of this paper is to explore the unique micro-level challenges that are faced by poverty alleviation programs adopted by microfinance institutions operating in this region.

Design/methodology/approach
The study used structured questionnaires to collect primary data. The sample covered 600 respondents randomly selected from three counties, namely, Wajir, Mandera and Marsabit. Three focus group discussions comprising 24 participants held to facilitate a deeper understanding of the challenges of poverty among the North Eastern Province’s communities when alleviated through micro-finance.

Findings
The results reveal that the illiteracy due to the weakness of education and the unfavorable basic and financial infrastructures such as roads, telecommunications network represents the most important challenges that may affect the success of micro-finance programs.

Research limitations/implications
These results recommend that both conventional and Islamic micro-finance might contribute positively for poverty alleviation for the poorest Kenyan region if the challenges are mitigated.

Practical implications
The study provides policy recommendations for the Kenya Government and the conventional and Islamic banks in Kenya to provide the expected support for the poorest area in the country.

Social implications
The result of this research might help the government, micro-finance providers and the donors to assist in alleviating the poverty of the Northern Kenyan community.

Originality/value
To overcome the challenges of alleviating poverty in the region of Northern Kenya.
Educational mismatch and its impact on earnings: evidence from Indian labour market
Authors: Sharma Swati , Sharma Prateek 
Published: October 2017

Purpose
The purpose of this paper is to examine the incidence and determinants of educational mismatch in the Indian labour market. It also attempts to measure the wage effects of educational mismatch, and other individual and work-related characteristics.

Design/methodology/approach
Educational mismatch is modelled using multiple Mincerian equations. Wage effects are measured using the novel identification strategy of Lewbel (2012), which constructs internal instruments to obviate potential endogeneity problems.

Findings
The authors find that the returns to over-education are positive and significant, while the returns to under-education are negative and significant. However, over-educated would earn less than the workers who have the same educational level, but who are engaged in occupations for which they are adequately educated.

Originality/value
This study is one of the earliest attempts to identify the determinants of educational mismatch in the Indian labour market. Additionally, it measures the effect of educational mismatch on labour market earnings, as well as marginal wage effects of each surplus (or deficit) year of education. Methodological improvements ensure that the results are robust to the sample selection bias, as well as the endogeneity bias.
Returns to education and occupations for Canadian Aboriginal people
Authors: Fan Lida , Brownlee Keith , Habibov Nazim N. , Neckoway Raymond 
Published: October 2017

Purpose
The purpose of this paper is twofold. First, drawing on a unique data set, the authors estimate the returns to education for Canadian Aboriginal people. Second, the authors explore the relationship between occupation and the economic well-being, measured as income, of Aboriginal people in an effort to provide a better understanding of the causes of income gaps for Aboriginal people.

Design/methodology/approach
The data used in this study is the Public Use Microdata File of Aboriginal People’s Survey, 2012. An ordered logit model is used to estimate the key determinants for income groups. Then the marginal effects of each variable, for the probability of being in each category of the outcomes, are derived.

Findings
All the explanatory variables, including demographic, educational and occupational variables, appeared statistically significant with predicted signs. These results confirmed relationships between income level and education and occupations.

Research limitations/implications
The data limitation of income, as a categorical variable prevents the precise estimation of the contributions of the dependent variables in dollar amount.

Social implications
In order to substantially improve the Aboriginal people’s market performance, it is important to emphasise the quality of their education and whether their areas of study could lead them to high-skilled occupations.

Originality/value
Attention is paid to the types of human capital rather than the general term of education.
Banking and credit extension: does religious diversity matter?
Authors: Ghosh Saibal 
Published: October 2017

PurposeWhile several facets of credit extension by banks have been extensively studied, one aspect which has largely bypassed the attention of researchers is the intrinsic attitude towards risk. To investigate this in detail the purpose of this paper is to employ data on India for an extended time period to understand whether religious diversity affects bank credit and other (flow) outcome variables, such as profitability, costs and returns.Design/methodology/approachGiven the longitudinal nature of the data, the author’s employ fixed effects regression methodology which enables us to control for unobserved characteristics that might affect the dependent variable.FindingsThe analysis indicates that religious diversity lowers credit off-take by lowering the number of accounts, although the number of deposit accounts improves. The behaviour however, differs across high- and low-income states and during the pre- and post-crisis periods. In addition, the evidence supports the fact that the overall negative credit response arises from the behaviour of national banks.Practical implicationsThe analysis explores an important and hitherto unidentified aspect driving banking outcomes in the Indian context. This would suggest that any policy intervention that seeks to influence bank behaviour would need to take on board the intrinsic risk-appetite of key stakeholders.Originality/valueTo the best of the author’s knowledge, this is one of the earliest studies for India to carefully examine the interface between religious diversity and bank behaviour.