bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercise intensity agreement, need satisfaction, and exercise behavior: A sex‐moderated mediation model
Authors: Teixeira D. S. , Andrade A. J. , Faria J. , Marques P. , Bastos V. , Rodrigues F. , Sousa A. M. , Pereira H. V. 
Published: September 2024

AbstractSeveral theoretical frameworks have been used to understand exercise adherence. Basic psychological needs (BPN), grounded on self‐determination theory, have received large attention for this purpose. More recently, the hedonic theory and the assumptions related to the exercise characteristics (e.g., intensity) that can bolster positive affective responses have been revitalized. This study aimed to explore the associations between the agreement of current exercise intensity and the one individually preferred, BPN satisfaction/frustration, enjoyment, the intention to continue exercise, and exercise frequency. Additionally, an exploration of the direct and indirect effects while testing sex as a moderator was performed. A sample of 369 exercisers (Mage = 43.6, standard deviation = 12.96; 214 females) enrolled in 26 health clubs participated in this study voluntarily. Data were received in a first‐approach descriptive and correlational analyses. Next, a moderated mediation was performed using model 15 (PROCESS v.4.2). As a result, agreement in preference for exercise intensity was positively associated with enjoyment (r = 0.35), intention (r = 0.43), and all needs satisfaction (ranging from r = 0.12 to r = 0.45) and negatively associated with all needs frustration (ranging from r = −0.15 to r = −0.31). In the moderated mediation analysis, the same pattern of results emerged in direct effects. Indirect effects were significant for autonomy in the enjoyment and frequency models. Findings suggest that promoting an individually adjusted training intensity may foster BPN satisfaction. It appears to be present an independent (of needs) and positive association with exercise enjoyment and intention to continue exercising.
Capsaicin‐mediated repair of circadian disruption‐induced Intestinal barrier damage via the gut microbiota
Authors: Deng Yupei , Lin Bolin , Ho Chi‐Tang , Xiao Jie , Cao Yong , Huang Jun‐qing , Lu Muwen 
Published: September 2024

AbstractCircadian clock serves as a regulator of gastrointestinal health, and the disruption of circadian rhythm may trigger the dysregulation of the intestinal barrier functions. This study investigated the effectiveness of capsaicin (CAP) in mitigating intestinal barrier dysfunction induced by circadian disruption in male SPF C57BL/6J mice. Our findings indicated that CAP supplementation attenuated abnormal weight gain, alterations in serum lipid levels, and misalignment in hepatic and colonic circadian clock gene expressions in mice caused by constant darkness (CD) treatment. The restoration of the intestinal barrier integrity was also observed through the increase in mucosal thickness and goblet cell numbers. Both the diversity and the circadian rhythm of gut microbiota were improved in CAP‐treated group. Correlation analysis indicated that CAP could modulate the gut microbiota by affecting intestinal barrier function and systemic metabolism in CD‐treated mice. These results highlight the potential of CAP as a functional food component in maintaining the intestinal barrier homeostasis through regulating gut microbiota.
Protein nutritional support: The prevention and regulation of colorectal cancer and its mechanism research
Authors: Feng Duo , Han Di , Li Mengjie , Li Hu , Li Na , Liu Tianxin , Wang Jing 
Published: September 2024

AbstractColorectal cancer (CRC) is a common malignant tumor of the digestive tract in China; its incidence rates and mortality rates have been on the rise in recent years, ranking third in terms of incidence and second in mortality. Rational dietary intervention plays an important role in human health, and prevention and adjuvant treatment of CRC through dietary supplementation is the most ideal and safest way to treat the disease at present. More importantly, dietary protein is the basis of our diet and the key nutrient to maintain the normal function of the human body. Therefore, this narrative review delivered an overview of the common causes and therapeutic treatments for CRC. It emphasized the importance of dietary interventions, with a particular focus on elucidating the distinct regulatory impacts of plant proteins, animal proteins, and their mixed proteins.
Genetic approach to discover a valuable gene for enhanced nutritional value in the edible filamentous fungus Fusarium venenatum
Authors: Jeon Hosung , Shin Soobin , Winarto Jessica , Bui Duc‐Cuong , Song Dae‐Geun , Son Hokyoung 
Published: September 2024

AbstractMycoprotein is critical in a dietary shift toward a more sustainable food system. However, the strain improvement for enhancing mycoprotein via genetic manipulation is lacking. Here, we investigated the functions of proteins related to ubiquitin and small ubiquitin‐like modifier (SUMO) modifications using a gene‐knockout strategy in Fusarium venenatum, a mycoprotein fungus closely related to the fungal genetics model species Fusarium graminearum. Among the candidate genes, we specifically focused on the putative SUMO‐associated gene UBQ14 based on phenotypic characteristics in F. graminearum. In the FvUBQ14 knockout mutant in F. venenatum, nutritional profiles showed prominent differences in amino acid and fatty acid composition compared to the wild‐type strain. Furthermore, through proteomic analysis, we confirmed that the loss of FvUBQ14 leads to metabolic changes, particular in amino acid biosynthesis and degradation, resulting in an increase in amino acid composition in F. venenatum. Our findings provide new insights into filamentous fungal food improvement through genetic engineering and contribute to advances in alternative protein industry.
Curcumin's effect in advanced and metastatic breast cancer patients treated with first or second‐line docetaxel: A randomized trial
Authors: Judith Passildas Jahanmohan , Maureen Bernadach , Mélanie Pouget , Fabrice Kwiatkowski , Isabelle Vanpraagh‐Doreau , Pascale Dubray‐Longeras , Catherine Abrial , Jean‐Marc Nabholtz , Hervé Curé , Valérie Delecroix , Philippe Chollet , Marie‐Ange Mouret‐Reynier 
Published: September 2024

AbstractBackgroundIn this study, we investigated whether the association of curcumin and docetaxel among advanced and metastatic breast cancer patients in first or second‐line treatment potentiated the objective response rate.Patients/MethodsA multicentre, randomized, open label, phase‐II study was conducted and included 42 patients from July 2009 to January 2017. The primary endpoint was the objective response rate of the docetaxel‐curcumin combination in comparison with docetaxel alone. The secondary endpoints were the assessment of clinical benefit, overall survival, time‐to‐progression, progression‐free survival, compliance, and safety. An interim analysis was planned to evaluate safety and efficacy.ResultsIn this interim analysis conducted on 37 patients (19 in the control group vs. 18 in the experimental group), no difference was observed for the objective response rate (p = 0.25, control 73.7% vs. experimental 55.6%). Concerning clinical benefit, overall survival and time‐to‐progression, we also failed to show any difference between the two arms. A slight tendency towards longer progression‐free survival at 12 months after randomization was observed in the curcumin group (65.5% vs. 41.4%) but this difference did not reach significance (p = 0.14).ConclusionIn this study, we showed for the first time that adding oral curcumin for advanced and metastatic breast cancer patients treated with first or second‐line docetaxel was not efficacious, although safe. Consequently, this study was stopped for reasons of futility. Further studies with a larger number of patients, a different curcumin preparation, a longer treatment period and a pharmacokinetic evaluation of curcumin are needed to explore the real efficacy of this compound.
Ambient ultraviolet radiation as a cardioprotective factor: A global and regional analysis
Authors: You Wenpeng 
Published: September 2024

AbstractBackgroundAmbient ultraviolet radiation (UVR) has been found to have a greater cardioprotective effect than previously believed. This study aimed to quantitatively measure the role of UVR in protecting against the progression of cardiovascular disease (CVD) in general on a global and regional scale.MethodsPopulation‐level data on UVR, CVD incidence, aging, economic affluence, CVD genetic background (indexed with the Biological State Index, Ibs), obesity prevalence, and urbanization were collected and analysed. The correlation between UVR and CVD was examined using bivariate correlations, partial correlation, and stepwise multiple linear regression. Countries were grouped to investigate regional correlations between UVR and CVD, and Fisher's r‐to‐z transformation was used to compare correlation coefficients.ResultsUVR showed a significant inverse correlation with CVD incidence rates in bivariate correlation analyses globally (r = − 0.775 and r = − 0.760, p < 0.001), as well as within high‐income (r = −0.704, p < 0.001) and low‐ and middle‐income countries (LMIC) (r = −0.851, p < 0.001). These correlations remained significant even after controlling for confounding variables (r = −0.689 to −0.812, p < 0.001). In stepwise regression models, UVR was found to be the most significant predictor of CVD incidence. The inverse correlation between UVR and CVD was stronger in LMICs compared to high‐income countries (z = −1.96, p < 0.050).ConclusionsLow ambient UVR may be a significant risk factor for the progression of CVD worldwide. The protective effect of UVR appears to be stronger in LMICs than in high‐income countries, suggesting a greater impact of UVR on CVD prevention in these regions. These findings emphasize the need for further research into the mechanisms underlying the cardioprotective effects of UVR and the development of public health strategies to mitigate CVD risk associated with low UVR exposure.
Intervertebral Cervical Disc Intensity (IVCDI) Detection and Classification on MRI Scans Using Deep Learning Methods
Authors: Erkoc M. Fatih , Ulutas Hasan , Sahin M. Emin 
Published: September 2024

ABSTRACTRadiologists manually interpret magnetic resonance imaging (MRI) scans for the detection of intervertebral cervical disc degeneration, which are often obtained in a primary care or emergency hospital context. The ability of computer models to work with pathological findings and aid in the first interpretation of medical imaging tests is widely acknowledged. Deep learning methods, which are commonly employed today in the diagnosis or detection of many diseases, show great promise in this area. For the detection and segmentation of intervertebral cervical disc intensity, we propose a Mask‐RCNN‐based deep learning algorithm in this study. The provided approach begins by creating an original dataset using MRI scans that were collected from Yozgat Bozok University. The senior radiologist labels the data, and three classes of intensity are chosen for the classification (low, intermediate, and high). Two alternative network backbones are used in the study, and as a consequence of the training for the Mask R‐CNN algorithm, 98.14% and 96.72% mean average precision (mAP) values are obtained with the ResNet50 and ResNet101 architectures, respectively. Utilizing the five‐fold cross‐validation approach, the study is conducted. This study also applied the Faster R‐CNN method, achieving a mAP value of 85.2%. According to the author's knowledge, no study has yet been conducted to apply deep learning algorithms to detect intervertebral cervical disc intensity in a patient population with cervical intervertebral disc degeneration. By ensuring accurate MRI image interpretation and effectively supplying supplementary diagnostic information to provide accuracy and consistency in radiological diagnosis, the proposed method is proving to be a highly useful tool for radiologists.
Miniature and cost‐effective self‐powered triboelectric sensing system toward rapid detection of puerarin concentration
Authors: Su Chang , Shao Jiajia , Yu Zeyang , Hasan Al Mahadi , Bao Chengmin , Bowen Chris R. , Li Chuanbo , Wang Zhong Lin , Yang Ya 
Published: September 2024

AbstractThe detection of puerarin concentration is an essential capability to study the functional role of the Pueraria root as a natural medicine and dietary source in the treatment of cardiovascular diseases and liver protection. Current methods to detect and measure puerarin concentration, such as ultraviolet–visible spectrophotometry (UV), are bulky, require an external power supply, and are inconvenient to use. Here, we propose a triboelectric puerarin‐detecting sensor (TPDS) which is based on liquid–solid contact electrification, in which liquid–solid interactions generate rapid electrical signals in only 0.4 ms to enable real‐time detection of puerarin concentration in water droplets. The electrical signal of the TPDS decreases with an increase of puerarin concentration, and the sensitivity of the approach is 520 V·(μg/mL)−1. The TPDS represents a miniature and cost‐effective sensor that is 0.2% of the size and 0.01% of the cost of a UV spectrophotometer. Our theoretical analysis verified that the puerarin concentration in droplets can effectively regulate the electronic structure, where higher concentrations of puerarin lead to a narrower energy bandgap, which allows the TPDS to detect puerarin concentration without the need for an external power supply. The TPDS therefore provides a route for the development of a portable and self‐powered method to measure the concentration of an active ingredient in droplets through the conversion of natural energy.image
Research progress on operation control and optimal scheduling of irrigation canal systems
Authors: Zhou Ke , Fan Yu , Gao Zhanyi , Chen Haorui , Kang Ye 
Published: September 2024

AbstractOpen canals are a common water transfer method used in water transfer projects and agricultural irrigation and drainage projects. With the emergence of drawbacks in traditional canal control models and the increasingly severe shortage of water resources, accurate transport and distribution of water in the canal system of the irrigation district, rational allocation of water resources, reduction in water loss, improvement in the efficiency and benefit of water resource utilization, and satisfaction of the water demand of different water users are needed. Many scholars have conducted extensive research on canal operation control and optimal scheduling. This paper systematically reviews and summarizes the relevant research progress, including the theory of unsteady flow in open canals, the operation mode of the canal system, the operation control model and algorithm of canal systems, and the optimization of water distribution in canal systems. By summarizing the research progress already achieved, the existing problems and future development directions are identified according to actual needs, providing a reference for the ongoing modernization of irrigation districts and the research and application of digital twin irrigation district technology.
Adsorptive removal of naproxen onto nano magnesium oxide‐modified castor wood biochar: Treatment of pharmaceutical wastewater via sequential Fenton's‐adsorption process
Authors: Bano Amreen , Aziz Mohd Kashif , Ameen Fuad , Singh Kavita , Prasad Bablu , Nandan  , Dave Hemen , Ravi Rajesh , Manjhi Jayanand , Kumari Madhu , Prasad Kumar Suranjit 
Published: September 2024

AbstractThis current investigation explored the thermal conversion process of castor wood into biochar, which was subsequently harnessed for removing naproxen from pharmaceutical industrial effluent via adsorption. Surface composition analyses conducted through scanning electron microscopy–energy dispersive X‐ray, laser‐induced breakdown spectroscopy, and Fourier‐transform infrared studies unveiled the presence of nano MgO particles within the adsorbent material. Employing optimization techniques such as response surface methodology facilitated a refined approach to batch study. The optimized conditions for batch naproxen sodium (NPX) adsorption on nano‐MgO‐modified biochar were identified as pH 4, 1.5 g/L adsorbent dosage, and a 120‐min contact time maintaining a constant NPX concentration of 10 mg/L. The adsorption capacity was calculated to be 123.34 mg/g for a nano‐magnesium oxide‐modified castor wood biochar (modified biochar) and 99.874 mg/g for pristine castor wood biochar (pristine biochar). Fenton's reagents comprising 15 mM of FeSO4 (7H2O) and 25 mM of H2O2 have been scrutinized under conditions of pH 3.0, a reaction time of 30 min, a temperature of 30°C, and stirring at 120 rpm, followed by batch adsorption treatment. The COD, NH3–N, NO3−, PO43−, and NPX removal percentages was found to be 90%, 87%, 79%, 80%, and 90%, respectively. Thus nano MgO‐modified biochar holds promise of treatment of pharmaceutical effluent.
COVID‐19, school closures and the retreat from educational aspirations
Authors: Glick Jennifer E. , Alcaraz Melissa , Randrianasolo Arinala , Yabiku Scott T. 
Published: September 2024

AbstractIntroductionAs a shared external shock, the coronavirus pandemic (COVID‐19) impacted health and well‐being around the world. Mitigation strategies employed in many locations included school closures and travel restrictions. These strategies directly impacted educational access and opportunities and created economic stressors for families. This study examines how these direct impacts also altered educational aspirations for children and adolescents, an important predictor of educational attainment.MethodWe estimate multilevel regression models using two waves of data, collected in 2017–18 and 2020‐21, from 1294 children and adolescents (Mean age = 13.1, SD = 2.8; 50.3% female) in Jalisco, Mexico, and 2201 children and adolescents (Mean age = 14.7, SD = 2.6; 49.1% female) in Chitwan Nepal. We examine changes in educational aspirations between the two waves (pre‐ and post‐COVID‐19 onset).ResultsInitial aspirations are positively associated with household wealth, caregiver education, and prior commitment to education. Multilevel regression models predicting changes in educational aspirations demonstrate these resources are important for maintaining high educational aspirations. But children and adolescents in households that experienced more economic loss following the external shock of the pandemic had lowered aspirations over time.ConclusionsDisruptions to schooling and economic shocks to households curtailed educational aspirations among children and adolescents in a similar way in two disparate settings. These results raise concerns about the educational attainment of children in the face of external shocks and the possibility that educational progress will stall in low resourced environments among the most vulnerable youth.
A review on eco‐sustainable photocatalytic degradation of pharmaceutical pollutants using biosynthesized nanoparticles
Authors: Emmanuel Stephen Sunday , Esan Akintomiwa Olumide , Afigo Festus Smith Oghenegaga , Adesibikan Ademidun Adeola , Idris Mustapha Omenesa 
Published: September 2024

AbstractPharmaceutical substances, a pill for every ill, have become a sweet poison by remarkably boosting the global economy as well as human and animal wellness and at the same time causing environmental pollution, especially in the aquatic ecosystem, and this has led to a fatal diminution in the availability of clean water and upsurge in water insecurity. Notably, traditional techniques and materials have been employed to clean up pharmaceutical pollutants (PP) from aquatic bodies; however, they have come under controversy because they require hazardous chemicals and cannot fully mineralize stubborn PPs. Interestingly, the photocatalytic degradation approach employing eco‐benign biosynthesized nanoparticles (BNP) is an avant‐garde practice and has shown to be an eco‐sustainable method that can fully mineralize PPs into harmless molecules. Thus, this study critically explores the application of BNPs for the photocatalytic degradation of PPs. The review revealed that the greatest degradation efficacy of BNPs was greater than 80% in most cases, and that the least amount of time required was around 10 min. In addition, the oxygen‐containing functional groups found in the biological sources used for the fabrication of BNPs contributed to the supremacy of •OH and O2• radicals in the degradation operation. Also, the photocatalytic degradation kinetic data was well modeled by pseudo‐first order, and this indicates that •OH was more involved in the PPs degradation operation than O2•. Moreso, BNPs have excellent reusability potential (>5 rounds) while maintaining inherent structural integrity. Techno‐economic analysis revealed that BNPs are cost‐effective, costing about $1.5/1,000,000 mL of pharmaceutical wastewater on average.
Evaluation of a Chemiluminescent Enzyme Immunoassay for the Detection of Prostaglandin E‐Major Urinary Metabolite (PGE‐MUM)
Authors: Takagi Jun , Moriyama Kazushige , Arihiro Seiji , Kato Tomohiro , Sakurai Toshiyuki , Saruta Masayuki , Wakabayashi Mie , Nasu Hidekazu , Katagiri Noriko , Yagi Shintaro 
Published: September 2024

ABSTRACTBackgroundWe developed a fully automated quantitative immunoassay for the detection of prostaglandin E‐major urinary metabolite (PGE‐MUM). In this study, we evaluated the analytical performance of this assay.MethodsSensitivity, within‐run reproducibility, correlation with radioimmunoassay (RIA), cross‐reactivity, dilution linearity, spike recovery performance, analyte stability, and effects of coexisting substances were evaluated. The assay was also used to measure PGE‐MUM in 211 healthy people.ResultsThe limit of detection and quantification were 1.0 and 1.3 ng/mL, respectively. When the assay was performed six times in a single run, the coefficient of variation ranged from 1.4% to 2.2%. The coefficient of correlation with a preceding RIA method was 0.970 with a correlation slope of 0.88. There was no cross‐reactivity with PGE‐MUM analogs. Linearity of dilution was confirmed at up to 16‐fold dilution with assay results within 100 ± 20% of the theoretical values calculated based on the undiluted sample. Spike recovery was good and ranged from 94% to 101%. Analyte stability was tested by storing samples at 25°C for 6 days, 10°C for 1 month, and by performing up to five freeze–thaw cycles. Assay results were all within 100 ± 10%, the values measured before storage and before the freeze–thaw process. Assay results in healthy people ranged from 3.1 to 162.7 ng/mL (mean: 35.8 ng/mL). After correction for creatinine, the 95% confidence interval was 8.68–42.25 μg/g creatinine.ConclusionThe assay precisely detects PGE‐MUM.