bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk‐based management of dental procedures in patients with inherited bleeding disorders: Development of a Dental Bleeding Risk Assessment and Treatment Tool (DeBRATT)
Authors: Rasaratnam L. , Chowdary P. , Pollard D. , Subel B. , Harrington C. , Darbar U. R. 
Published: January 2017

IntroductionSuccessful outcomes in dental management for patients with inherited bleeding disorders require close collaboration between haematology teams and dentists.AimTo review outcomes of an interdisciplinary pathway for dental procedures by assessing adequacy and appropriateness of haemostatic management.MethodsTwo hundred dental procedures in 30 patients with inherited bleeding disorders were included. A Dental Bleeding Risk Assessment and Treatment Tool (DeBRATT) was developed to identify four categories of bleeding risk (no risk, low, moderate and high risk of bleeding) in relation to the severity of the bleeding disorder and the invasiveness of dental procedure. The adequacy and appropriateness of haemostatic therapy provided in relation to the bleeding risk was assessed with reference to the published literature. Treatment was classified as appropriate, over or under‐treatment. Bleeding complication was the primary outcome.ResultsA high level of dental disease was noted, with 83% of patients having at least one decayed tooth and 46.7% having chronic gum disease. A total of 59.1% of the dental procedures in patients with mild bleeding disorders were over‐treated (n = 65/110) and 8.9% in patients with severe disorders had an extended duration of treatment (n = 7/79). One bleeding complication was observed in a patient with Von Willebrand's disease and severe thrombocytopenia. All other procedures (99.5%) were uneventful.ConclusionDeBRATT enables a risk‐based approach for the management of dental procedures in patients with inherited bleeding disorders. The tool facilitates a comprehensive evaluation of bleeding risk with the potential to minimize unnecessary treatment and aid interdisciplinary communication among different clinical teams.
Chemical, biological, and antibacterial characterization of silica glass containing silver and gold nanoparticles
Authors: Catauro Michelina , Papale Ferdinando , Caputo Pina , Donnarumma Giovanna 
Published: January 2017

AbstractThe aim of this study has been the preparation of sol‐gel glasses with potential antibacterial properties. Bioactive glasses containing different percentages of silver and gold nanoparticles have been synthesized via the sol‐gel method. The obtained glasses have 0.5, 1, 1.5, and 2 wt% silver as well as a constant amount of gold nanoparticles (AuNP) added as colloidal solution (15 wt%). Fourier Transform Infrared (FTIR) spectroscopy was used to characterize the materials. Scanning electron microscopy (SEM) has been used to investigate the surface of each sample. Moreover, the materials have been characterized in order to verify their antibacterial activities as well as their bioactivity and cytocompatibility as a function of Ag and Au content. SEM/EDX analysis has shown that the samples are bioactive because they are able to stimulate hydroxyapatite nucleation on their surface when soaked in a simulated body fluid (SBF). WST‐8 assay of 3T3 cells, placed in contact with the material extracts, has showed that the glass does not induce cytotoxicity. Staphylococcus epidermidis and Pseudomonas aeruginosa strains have been used for the evaluation of the antibacterial properties of each sample. The experimental data have shown that all synthesized materials have antibacterial activity. However, the two bacterial strains respond differently to the materials. The data show that the presence of AuNP causes a decrease in the antibacterial activity of Ag+ ions.
Knowledge about, attitude toward, and practice of skin lightening products use and its social correlates among university students in five Association of Southeast Asian Nations (ASEAN) countries
Authors: Peltzer Karl , Pengpid Supa 
Published: January 2017

AbstractBackgroundThe aim of this study was to investigate the knowledge about, attitude toward, and use of skin lightening products (SLP) and its social and psychological correlates among university students from five Association of Southeast Asian Nations (ASEAN) countries.MethodsIn a cross sectional survey, 3259 undergraduate university students (Mean age = 20.5 years, SD = 1.6) from five ASEAN countries responded to an anonymous questionnaire. Multivariate logistic regression analysis was used to identify associations between sociodemographic characteristics, knowledge, attitude, poor mental health, and SLP use.ResultsOverall, 79.1% of the students were aware that the use of SLP can harm the skin, and 30.1% knew the active ingredients of SLP. Most students had a positive perception of having a lighter skin tone and SLP. Overall, the prevalence of SLP use over the past 12 months was 30.7%, 16.7% of male, and 30.0% of female students, ranging from 13.4% in Myanmar to 69.4% in Thailand. In multivariate logistic regression analysis, among women, older age, coming from a poorer family, residing in an upper middle income country, awareness of active skin lightening ingredients, and poor mental health were associated with SLP, while among men, not aware of the negative effects of SLP and awareness of active skin lightening ingredients and poor mental health were associated with SLP use.ConclusionA high prevalence of SLP use was found in a large sample of ASEAN university students, and several social and mental health‐related risk factors were found that may help in guiding interventions.
Shifting the Beveridge curve: What affects labour market matching?
Authors: BOVA Elva , TOVAR JALLES João , KOLERUS Christina 
Published: January 2017

AbstractThis article explores short‐run determinants of the matching between labour demand and supply by identifying shifts in the Beveridge curves for 12 OECD countries between 2000Q1 and 2013Q4. Using three complementary methodologies (visual examination, cointegration techniques and non‐linear estimations), we find that labour force growth and employment protection legislation reduce the likelihood of outward shifts, and the higher the share of employees with intermediate levels of education and the long‐term unemployment, the more difficult the matching process. Active labour market policies (such as incentives for start‐ups or job‐sharing programmes) could facilitate matching, while passive policies (unemployment benefits or labour taxation) make matching significantly more difficult.
Claims to the benefits of clinical supervision: A critique of the policy development process and outcomes in New South Wales, Australia
Authors: White Edward 
Published: January 2017

AbstractThe historical development of clinical supervision has been variously interpreted in the international literature. Creditable evidence has accumulated, particularly over the past two decades, to show that clinical supervision has a positive demonstrable effect on supervisees. However, comparatively little research evidence has entered the public domain on any effect that clinical supervision might have on other nominated outcomes. In Australia, developments in clinical supervision were recently prompted by initiatives at national and state levels. Since 2010, lead agencies for these have sought feedback from professional bodies and organizations on a number of inter‐related draft policy documents. The present article tracked changes over time between the draft and final versions of these documents in New South Wales, and reviewed the original sources of literature cited within them. The strength of evidence upon which the final published versions were reportedly predicated was scrutinized. Upon examination, claims to the wider benefits of clinical supervision were found to be unconvincingly supported, not least because the examples selected by the agencies from the international literature and cited in their respective documents were either silent, parsimonious, or contradictory. Many claims remain at the level of folklore/hypothetical propositions, therefore, and stay worthy of rigorous empirical testing and faithful public reporting. Such investigations have been acknowledged as notoriously difficult to conduct. The present article identified noteworthy examples in the contemporary literature that signpost robust ways forward for empirical outcomes‐orientated research, the findings from which might strengthen the evidence base of future policy documents.
Challenges faced by older nurses in Singapore: a mixed methods study
Authors: Ang S.Y. , Ayoob S.B.M. , Hussain N.B.S. , Uthaman T. , Adenan H. , Chiang P. , Ong L.T. , Fong M.K. , Ostbye T. 
Published: January 2017

BackgroundIn Singapore, employees aged 62–65 can continue to be employed if they meet the re‐employment eligibility criteria. This policy, coupled with an ageing workforce, calls for age‐friendly initiatives, specific to work‐related challenges faced by older nurses.AimTo determine work‐related challenges faced by older nurses.MethodsA mixed method sequential explanatory study was conducted with nurses, aged 50 and above, working in a healthcare cluster in Singapore. In the quantitative phase, a questionnaire was administered to 534 nurses to elicit work‐related challenges, then in‐depth interviews with 30 nurses were carried out to help explain why certain tasks and work circumstances became harder.ResultsResults of the survey indicated that the top three challenges were coping with changes, working with computers and reading labels. Place of work, salary range, gender and race were significantly associated with different work‐related challenges. Five themes emerged from the qualitative data: physical demands of work and workload, new technology, need for further education, working with younger nurses and in intercultural teams, and changing public expectations and professional image.Discussion and conclusionThe study supports the current literature on the challenges older nurses face with technological advancement. However, older nurses in our study reported less aches and pain as compared to that reported elsewhere. There is a need for specific strategies that will address changes in work processes and environment in order to retain older nurses.Implications for nursing and nursing policyWhen devising age‐friendly work improvement initiatives, it is important for nurse leaders to factor in the needs of nurses working in different care environments, who are of different ranks, or are from different ethnic backgrounds.
Decreasing Rates of Pediatric Bipolar Within an Outpatient Practice
Authors: Wesemann Daniel 
Published: January 2017

PROBLEMPediatric bipolar disorder (PBD) prevalence is estimated to be 1–3%. Nationally and internationally, rates of PBD have increased by over 400%. However, in Iowa and at one psychiatric clinic in Iowa, from 2008–2013, there was a decrease in PBD diagnosis of 33 and 51.2% respectively. This study examined the diagnosing practices of PBD by local providers in one outpatient mental health center.METHODParents completed a screening packet to differentiate between PBD and attention deficit hyperactivity disorder (ADHD) using three tools: Child Mania Rating Scale (CMRS), Child Behavior Checklist‐Mania Scale (CBCL‐MS), and the NICHQ Vanderbilt. Symptom agreement analysis between the screeners and the provider's clinical diagnoses was performed using ANOVA and Tukey HSD posthoc analysis.FINDINGSA 19.6% of the participants were positive for PBD on the CMRS and 55.9% were positive on the CBCL‐MS. A total of 36.60% were positive for ADHD on the Vanderbilt. The screening data compared to the provider's clinical diagnosis showed no diagnostic agreement for PBD (p < .05). Providers’ rates of diagnosing PBD did not match the rate of PBD symptoms identified by the screeners.CONCLUSIONFurther evidence to determine the criteria and use of current screening measures for PBD is needed to guide practice for distinguishing PBD from related disorders.
Effect of ultrasound and storage time on quality attributes of strawberry juice
Authors: Tomadoni Barbara , Cassani Lucia , Viacava Gabriela , Moreira Maria Del Rosario , Ponce Alejandra 
Published: January 2017

AbstractThe aim of this study was to evaluate changes in quality attributes of non‐clarified strawberry juice during storage at 5 °C after ultrasonication at 40 kHz for 10 and 30 min in comparison with thermally treated juice at 90 °C for 60 s. Ultrasound treatments maintained color parameters with no significant differences (p < .05) from untreated sample, while thermally treated juice showed lower L* values and higher hue angles than the control. No significant differences in °Brix and total acidity were found between treated and untreated samples, and both parameters remained unchanged throughout storage. Compared to the control, ultrasound treatments showed no significant reductions on day 0 in mesophilic and psychrophilic bacteria, and yeast and molds counts. However, the treatments showed significant decrease in the microbial growth rate through storage time, and significant increase in both polyphenol content and antioxidant activity, compared to control.Practical applicationsWith today's tendency towards the consumption of nutritious and fresh‐like foods, non‐thermal treatments are gaining popularity. Among them, ultrasound has become a feasible alternative against traditional thermal treatments. Strawberry products are considered of great nutritional value, because of their high content in antioxidant compounds and vitamin C. In this study, ultrasound was evaluated in strawberry juice through storage time, where significant reductions on microbial growth rate were achieved; meaning that shelf‐life of the product was increased compared to control. Furthermore, physicochemical parameters were maintained through storage, and antioxidant capacity and polyphenol content showed a significant increment, which implies that nutritional value of the product was increased by ultrasound treatments. Therefore, sonication is a potential technology that can easily be applied at the fruit juice industry, replacing the traditional thermal treatment which compromises the organoleptical and nutritional quality of the final product.
Indigenous Empowerment or State Instrumentalization? The Formalization of Indigenous Justices in Michoacán, México
Authors: Andrade Orlando Aragón 
Published: January 2017

ResumenEl reconocimiento formal, o la formalización de las justicias indígenas en México, ¿ha empoderado a las comunidades indígenas con más derechos de autonomía? Este artículo intenta responder a esta interrogante mediante un análisis del Estado de Michoacán. Analiza dos fases distintas del proceso de formalización. Primero, la inclusión y legislación de formas “indígenas” de justicia dentro del sistema legal michoacano; y, segundo, la primera experiencia de poner en operación la reforma a través del Tribunal Comunal Purépecha entre 2007 y 2009. Sobre la base de este análisis se sugiere que lejos de empoderar a las comunidades indígenas, el proceso de formalización legal ha restringido su autonomía para ejercer sus distintas formas de justicia.
RISK‐COPING, LAND TENURE AND LAND MARKETS: AN OVERVIEW OF THE LITERATURE
Authors: Promsopha Gwendoline 
Published: January 2017

AbstractOver the last decades, a significant amount of literature has been published on informal risk‐coping in developing countries. In this paper, we review how informal risk‐coping has been addressed in the land tenure literature from two main perspectives: a first stream of research looks at how customary tenure and communal property perform key informal risk‐coping functions. A second subset of this literature analyses how informal risk‐coping creates land market imperfections through sharecropping or distress sales. The segmentation of the literature results from the Demsetzian property rights framework. Further research on risk‐coping and land tenure would benefit from examining recent work on property regimes.
INTRA‐HOUSEHOLD EXPERIMENTS: A SURVEY
Authors: Munro Alistair 
Published: January 2017

AbstractExperiments with family groups are rare, but since many decisions are taken at the household level or occur within the household it is an important area to investigate. This paper provides a survey of the recent experimental work on intra‐household decision‐making. I discuss some of the challenges involved in doing experiments with couples and families and consider major areas that remain yet to be explored. While general themes from the research are still emerging, four results repeatedly occur: (1) the absence of efficiency in intra‐household decisions; (2) joint decisions that are not a convex combination of individual decisions; (3) individual behaviour is affected by opportunities for hiding actions from spouses and (4) deviations from standard models of microeconomics in line with those seen in the anomalies literature of individual decision‐making.
Long‐term side effects on the temporomandibular joints and oro‐facial function in patients with obstructive sleep apnoea treated with a mandibular advancement device
Authors: Knappe S. W. , Bakke M. , Svanholt P. , Petersson A. , Sonnesen L. 
Published: January 2017

SummaryPatients with obstructive sleep apnoea (OSA) in long‐term treatment with a mandibular advancement device (MAD) to increase the upper airway space may develop changes in the temporomandibular joint (TMJ) and the oro‐facial function due to the protruded jaw position during sleep. The aim was to investigate the influence of long‐term MAD treatment on the TMJs, oro‐facial function and occlusion. This prospective study included 30 men and 13 women (median age 54) with OSA [Apnoea–Hypopnoea Index (AHI): 7–57]. They were examined with the Nordic Orofacial Test Screening (NOT‐S), the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and cone beam computed tomography (CBCT) of the TMJs. The examination was performed before MAD treatment (T0), and 3–6 months (T1, no CBCT), 1 year (T2) and 3 years (T3) after treatment start. The results were analysed as long term (T0–T3, n = 14) and short term (T0–T2, n = 24) by t‐test, Fisher's exact test and anova. Both long‐ and short‐term analyses revealed a reduction in AHI (P < 0·002). Significant long term were increased scores in the NOT‐S Interview (P < 0·045), reduced vertical overbite (P < 0·031) and increased jaw protrusive movement (P < 0·027). TMJ changes were found as joint sounds in terms of reciprocal clicking and crepitus, short term as a decrease and subsequent recurrence (P < 0·053; P < 0·037). No significant radiological changes were found. In conclusion, MAD treatment is beneficial to some OSA patients, but might induce changes in the TMJs, the oro‐facial function and the occlusion. However, these changes seemed to be less harmful than previously reported with careful adaptation, control and follow‐ups.
Potentiation of biological effects of mesenchymal stem cells in ischemic conditions by melatonin via upregulation of cellular prion protein expression
Authors: Lee Jun Hee , Han Yong‐Seok , Lee Sang Hun 
Published: January 2017

AbstractMesenchymal stem cells (MSCs) are promising candidates for stem cell‐based therapy in ischemic diseases. However, ischemic injury induces pathophysiological conditions, such as oxidative stress and inflammation, which diminish therapeutic efficacy of MSC‐based therapy by reducing survival and functionality of transplanted MSCs. To overcome this problem, we explored the effects of melatonin on the proliferation, resistance to oxidative stress, and immunomodulatory properties of MSCs. Treatment with melatonin enhanced MSC proliferation and self‐renewal via upregulation of cellular prion protein (PrPC) expression. Melatonin diminished the extent of MSC apoptosis in oxidative stress conditions by regulating the levels of apoptosis‐associated proteins, such as BCL‐2, BAX, PARP‐1, and caspase‐3, in a PrPC‐dependent manner. In addition, melatonin regulated the immunomodulatory effects of MSCs via the PrPC‐IDO axis. In a murine hind‐limb ischemia model, melatonin‐stimulated MSCs improved the blood flow perfusion, limb salvage, and vessel regeneration by lowering the extent of apoptosis of affected local cells and transplanted MSCs as well as by reducing infiltration of macrophages. These melatonin‐mediated therapeutic effects were inhibited by silencing of PrPC expression. Our findings for the first time indicate that melatonin promotes MSC functionality and enhances MSC‐mediated neovascularization in ischemic tissues through the upregulation of PrPC expression. In conclusion, melatonin‐treated MSCs could provide a therapeutic strategy for vessel regeneration in ischemic disease, and the targeting of PrPC levels may prove instrumental for MSC‐based therapies.
HsfA1a upregulates melatonin biosynthesis to confer cadmium tolerance in tomato plants
Authors: Cai Shu‐Yu , Zhang Yun , Xu You‐Ping , Qi Zhen‐Yu , Li Meng‐Qi , Ahammed Golam Jalal , Xia Xiao‐Jian , Shi Kai , Zhou Yan‐Hong , Reiter Russel J. , Yu Jing‐Quan , Zhou Jie 
Published: January 2017

AbstractMelatonin regulates broad aspects of plant responses to various biotic and abiotic stresses, but the upstream regulation of melatonin biosynthesis by these stresses remains largely unknown. Herein, we demonstrate that transcription factor heat‐shock factor A1a (HsfA1a) conferred cadmium (Cd) tolerance to tomato plants, in part through its positive role in inducing melatonin biosynthesis under Cd stress. Analysis of leaf phenotype, chlorophyll content, and photosynthetic efficiency revealed that silencing of the HsfA1a gene decreased Cd tolerance, whereas its overexpression enhanced plant tolerance to Cd. HsfA1a‐silenced plants exhibited reduced melatonin levels, and HsfA1a overexpression stimulated melatonin accumulation and the expression of the melatonin biosynthetic gene caffeic acid O‐methyltransferase 1 (COMT1) under Cd stress. Both an in vitro electrophoretic mobility shift assay and in vivo chromatin immunoprecipitation coupled with qPCR analysis revealed that HsfA1a binds to the COMT1 gene promoter. Meanwhile, Cd stress induced the expression of heat‐shock proteins (HSPs), which was compromised in HsfA1a‐silenced plants and more robustly induced in HsfA1a‐overexpressing plants under Cd stress. COMT1 silencing reduced HsfA1a‐induced Cd tolerance and melatonin accumulation in HsfA1a‐overexpressing plants. Additionally, the HsfA1a‐induced expression of HSPs was partially compromised in COMT1‐silenced wild‐type or HsfA1a‐overexpressing plants under Cd stress. These results demonstrate that HsfA1a confers Cd tolerance by activating transcription of the COMT1 gene and inducing accumulation of melatonin that partially upregulates expression of HSPs.
TTA‐Rapid in the treatment of the canine cruciate deficient stifle: short‐ and medium‐term outcome
Authors: Butterworth S. J. , Kydd D. M. 
Published: January 2017

ObjectivesTo evaluate complications, short‐ and medium‐term outcomes following treatment of lameness associated with cranial cruciate ligament insufficiency in dogs using the “TTA‐Rapid” technique.MethodsPatient records from two veterinary clinics were retrospectively examined to collect data from cases treated over a period of 21 months. An owner postal questionnaire using a clinical metrology instrument (Liverpool Osteoarthritis in Dogs) evaluated medium‐term outcome of at least six months.ResultsIn total 152 procedures were carried out in 141 dogs by two surgeons. Major complications, requiring further intervention, were identified in 11 (7%). Nine of these involved “late” meniscal injuries and two sustained tibial fractures postoperatively, one requiring internal fixation and the other external coaptation. The 3‐month outcome was considered satisfactory in 99% of 135 procedures whilst the medium‐term outcome (mean 16 months) was considered satisfactory in 86% of 108 dogs.Clinical Significance“TTA‐Rapid” offers a treatment option for cranial cruciate‐deficient stifles with good short‐ and medium‐term outcomes. The complication rate was low in our hands.