bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of ventricular electrical heterogeneity in left bundle branch pacing and left ventricular septal pacing by using various electrophysiological methods
Authors: Rijks Jesse H. J. , Heckman Luuk , Westra Sjoerd , Cornelussen Richard , Ghosh Subham , Curila Karol , Smisek Radovan , Grieco Domenico , Bressi Edoardo , Nguyên Uyên Châu , Lumens Joost , van Stipdonk Antonius M.W. , Linz Dominik , Prinzen Frits W. , Luermans Justin G. L. M. , Vernooy Kevin 
Published: September 2024

AbstractIntroductionLeft bundle branch area pacing (LBBAP) comprises pacing at the left ventricular septum (LVSP) or left bundle branch (LBBP). The aim of the present study was to investigate the differences in ventricular electrical heterogeneity between LVSP, LBBP, right ventricular pacing (RVP) and intrinsic conduction with different dyssynchrony measures using the ECG, vectorcardiograpy, ECG belt, and Ultrahigh frequency (UHF‐)ECG.MethodsThirty‐seven patients with a pacemaker indication for bradycardia or cardiac resynchronization therapy underwent LBBAP implantation. ECG, vectorcardiogram, ECG belt and UHF‐ECG signals were recorded during RVP, LVSP and LBBP, and intrinsic activation. QRS duration (QRSd) was measured from the ECG, QRS area was calculated from the vectorcardiogram, LV activation time (LVAT) and standard deviation of activation time (SDAT) from ECG belt and electrical dyssynchrony (e‐DYS16) from UHF‐ECG.ResultsBoth LVSP and LBBP significantly reduced ventricular electrical heterogeneity as compared to underlying LBBB and RV pacing in terms of QRS area (p < .001), SDAT (p < .001), LVAT (p < .001) and e‐DYS16 (p < .001). QRSd was only reduced as compared to RV pacing(p < .001). QRS area was similar during LBBP and normal intrinsic conduction, e‐DYS16 was similar during LVSP and normal intrinsic conduction, whereas SDAT was similar for LVSP, LBBP and normal intrinsic conduction. For all these variables there was no significant difference between LVSP and LBBP.ConclusionBoth LVSP and LBBP resulted in a more synchronous LV activation than LBBB and RVP. Especially LBBP resulted in levels of LV synchrony comparable to normal intrinsic conduction.
Health‐related quality of life in cutaneous T‐cell lymphoma: A post hoc analysis of a phase 3 trial in mycosis fungoides and Sézary syndrome
Authors: Ortiz Romero P. L. , Kim Y. H. , Molloy K. , Quaglino P. , Scarisbrick J. , Thornton S. , Sandilands K. , Dent J. E. , Nixon A. , Williams A. , Shinohara M. M. 
Published: September 2024

AbstractBackgroundMycosis fungoides (MF) and Sézary syndrome (SS) are common subtypes of cutaneous T‐cell lymphoma that primarily affect the skin but may spread to the lymph nodes, viscera and blood. The symptom burden may compromise health‐related quality of life (HRQL). The phase 3 MAVORIC study (ClinicalTrials.gov identifier NCT01728805) in patients with relapsed/refractory MF/SS reported improved HRQL with mogamulizumab compared with vorinostat.ObjectivesUse baseline (pre‐treatment) data from the MAVORIC study to describe the symptom burden of MF/SS and identify characteristics associated with worse HRQL.MethodsData were from 372 adults with stage IB–IVB histologically confirmed relapsed/ refractory MF or SS. Associations between demographic and medical history variables and worse HRQL (Skindex‐29, ItchyQol and Functional Assessment of Cancer Therapy – General [FACT‐G]) were determined by regression models.ResultsIn the cohort of 372 adults, 70% were white; 42% were female; mean age was 63 (SD 13.0) years. Fifty‐five per cent had MF and 45% had SS; 77% had advanced (stage IIB–IV) disease, involving the skin in all patients and the blood and/or nodes in 66%. HRQL scores showed impairment versus normative means (where available), with the greatest impact on Symptoms and Emotions in the Skindex‐29, Functioning in the ItchyQol, and Functional Wellbeing in the FACT‐G. In regression analysis, worse HRQL across all domains and total score was associated with being female and younger, worse mSWAT score and worse itch for the Skindex‐29 (n = 352), and being female, younger, Black/African American, worse performance status and worse itch for the ItchyQol (n = 369). Associations across domains and total score were not found for the FACT‐G. Associations between domains and demographic/medical history were seen for all instruments.ConclusionsThe symptoms of advanced MF/SS compromise all HRQL domains. Treatment goals and therapeutic choice should be informed by individual patients' disease burden.
The Experience and Needs of Living With Home Parenteral Nutrition in Adult Patients: A Meta‐Synthesis of Qualitative Studies
Authors: Fu Manyi , Shi Ming , Li Mengjie , He Guijuan 
Published: September 2024

ABSTRACTBackgroundHome parenteral nutrition (HPN) can improve the nutritional status of patients with gastrointestinal dysfunction. However, some patients face a series of challenges during its implementation, which significantly affect their quality of life.AimsTo explore the experience and needs of living with home parenteral nutrition in adult patients.DesignA systematic review and meta‐synthesis.MethodsA search was conducted across multiple databases, including PubMed, Embase, Cochrane Library, Web of Science, Chinese Biomedical Literature Service System, China National Knowledge Infrastructure, Wanfang Database and Wipu Database, to explore the real‐life experiences and needs of adult patients receiving HPN. The search covered the period up to March 2024. Qualitative research quality was evaluated using the Joanna Briggs Institute's Australian Centre for Evidence‐Based Health Care Quality Assessment Criteria for Qualitative Research. Data synthesis was performed using Thomas and Harden's method of thematic and content analysis.ResultsTwelve studies, each offering qualitative data, were analysed, resulting in the identification of four themes: positive experiences of HPN; the interplay of dynamic changes across physical, mental and social levels; self‐adjustment to the new normal; and multidimensional needs of patients receiving HPN.ConclusionsPatients receiving HPN face multiple challenges physically, psychologically and socially. This paper also reveals the supportive needs of patients in adapting to a new lifestyle with HPN. This indicates that healthcare professionals should provide comprehensive, continuous and dynamic supportive medical services to facilitate patients' reintegration and return to normal social life.Patient and Public InvolvementAs this study constitutes a meta‐synthesis, patient or public contribution is not applicable.Reporting ApproachAdhering to the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) reporting guidelines, this meta‐synthesis was conducted.
The quest for a qualitative hedonism
Authors: Dorsey Dale 
Published: September 2024

AbstractIn this paper, I attempt to articulate a version of qualitative hedonism, grounded in the value theory of the British Moralists. I argue that this view is novel, presents substantial advantages over alternative hedonisms (including rival approaches to qualitative hedonism and its quantitative cousin), and can avoid classic challenges to qualitative hedonism that emerged in the post‐Mill era. If I succeed, this is a significant result for substantive value theory, given the dismissiveness with which qualitative hedonism is generally treated in the literature on the good.
Leveraging programmed cell death patterns to predict prognosis and therapeutic sensitivity in OSCC
Authors: Wang An , Zhang Chi , Wang Yuhan , Diao Pengfei , Cheng Jie 
Published: September 2024

AbstractObjectivesIntricate associations between programmed cell death (PCD) and cancer development and treatment outcomes have been increasingly appreciated. Here, we integrated 12 PCD patterns to construct a novel biomarker, cell death index (CDI), for oral squamous cell carcinoma (OSCC) prognostication and therapeutic prediction.Materials and MethodsUnivariate Cox regression, Kaplan–Meier survival, and LASSO analyses were performed to construct the CDI. A nomogram combining CDI and selected clinicopathological parameters was established by multivariate Cox regression. The associations between CDI and immune landscape and therapeutic sensitivity were estimated. Single‐cell RNA‐seq data of OSCC was used to infer CDI genes in selected cell types and determine their expression along cell differentiation trajectory.ResultsTen selected PCD genes derived a novel prognostic signature for OSCC. The predictive prognostic performance of CDI and nomogram was robust and superior across multiple independent patient cohorts. CDI was negatively associated with tumor‐infiltrating immune cell abundance and immunotherapeutic outcomes. Moreover, scRNA‐seq data reanalysis revealed that GSDMB, IL‐1A, PRKAA2, and SFRP1 from this signature were primarily expressed in cancer cells and involved in cell differentiation.ConclusionsOur findings established CDI as a novel powerful predictor for prognosis and therapeutic response for OSCC and suggested its potential involvement in cancer cell differentiation.
ANOTHER STRAND IN THE WEB. THE CONNECTION BETWEEN NEA PAPHOS AND THE REGION OF NORTH‐WESTERN CYPRUS BASED ON AN INTEGRATED INVESTIGATION OF THE MIDDLE AND LATE ROMAN COOKING POTTERY
Authors: Nocoń Kamila , Marzec Edyta 
Published: September 2024

SummaryThe focus of this paper is the Middle and Late Roman (third–seventh centuries AD) cooking pottery recovered during the excavations at the Agora in Nea Paphos. Macroscopic investigation suggested that a part of this assemblage was imported from north‐western Cyprus. To verify this assumption, selected samples were analysed with thin section petrography and wavelength dispersive X‐ray fluorescence spectrometry. The results of an integrated macroscopic and laboratory analysis indicated the presence of two typologically distinguishable groups characterized by the same fabric. Comparative studies suggest that they were likely produced in the area of Dhiorios located in north‐western Cyprus. It was also noted that the cooking pottery vessels characterized by the same fabric were being imported to Nea Paphos already in the first century AD. The continuity of the production and exportation of the Dhiorios pottery suggests the economic importance of north‐western Cyprus throughout the entire Roman period.
Nutrient and Water Availability Influence Rice Physiology, Root Architecture and Ionomic Balance via Auxin Signalling
Authors: Manna Mrinalini , Rengasamy Balakrishnan , Sinha Alok Krishna 
Published: September 2024

ABSTRACTWater and soil nutrients are the vital ingredients of crop production, and their efficient uptake is essentially dependent on root development, majorly regulated by auxin. For a water‐loving crop like rice, how water availability regulates nutrient acquisition, additionally, how ambient nutrient level modulates water uptake, and the role of auxin therein is not well studied. While investigating the cross‐talks among these components, we found water to be essential for auxin re‐distribution in roots and shaping the root architecture. We also found that supplementing rice seedlings with moderate concentrations of mineral nutrients facilitated faster water uptake and greater nutrient enrichment in leaves compared to adequate nutrient supplementation. Additionally, moderate nutrient availability favoured greater stomatal density, stomatal conductance, photosynthesis, transpiration rate and water use efficiency when water was not limiting. Further, auxin supplementation enhanced root formation in rice, while affecting their water uptake ability, photosynthesis and transpiration causing differential mineral‐specific uptake trends. The present study uncovers the existence of an intricate crosstalk among water, nutrients and auxin signalling the knowledge of which will enable optimizing the growth conditions for speed breeding of rice and harnessing the components of auxin signalling to improve water and nutrient use efficiency of rice.
A note on a Halmos problem
Authors: Contino Maximiliano , Gallardo‐Gutiérrez Eva A. 
Published: September 2024

AbstractWe address the existence of non‐trivial closed invariant subspaces of operators on Banach spaces whenever their square have or, more generally, whether there exists a polynomial with such that the lattice of invariant subspaces of is non‐trivial. In the Hilbert space setting, the ‐problem was posed by Halmos in the seventies and in 2007, Foias, Jung, Ko and Pearcy conjectured it could be equivalent to the Invariant Subspace Problem.
Local wakefulness‐like activity of layer 5 cortex under general anaesthesia
Authors: Pardo‐Valencia Jesús , Moreno‐Gomez Miryam , Mercado Noelia , Pro Beatriz , Ammann Claudia , Humanes‐Valera Desire , Foffani Guglielmo 
Published: September 2024

AbstractConsciousness, defined as being aware of and responsive to one's surroundings, is characteristic of normal waking life and typically is lost during sleep and general anaesthesia. The traditional view of consciousness as a global brain state has evolved toward a more sophisticated interplay between global and local states, with the presence of local sleep in the awake brain and local wakefulness in the sleeping brain. However, this interplay is not clear for general anaesthesia, where loss of consciousness was recently suggested to be associated with a global state of brain‐wide synchrony that selectively involves layer 5 cortical pyramidal neurons across sensory, motor and associative areas. According to this global view, local wakefulness of layer 5 cortex should be incompatible with deep anaesthesia, a hypothesis that deserves to be scrutinised with causal manipulations. Here, we show that unilateral chemogenetic activation of layer 5 pyramidal neurons in the sensorimotor cortex of isoflurane‐anaesthetised mice induces a local state transition from slow‐wave activity to tonic firing in the transfected hemisphere. This wakefulness‐like activity dramatically disrupts layer 5 interhemispheric synchrony with mirror‐image locations in the contralateral hemisphere, but does not reduce the level of unconsciousness under deep anaesthesia, nor in the transitions to/from anaesthesia. Global layer 5 synchrony may thus be a sufficient condition for anaesthesia‐induced unconsciousness, but is not a necessary one, at least under isoflurane anaesthesia. Local wakefulness‐like activity of layer 5 cortex can be induced and maintained under deep anaesthesia, encouraging further investigation into the local vs. global aspects of anaesthesia‐induced unconsciousness.
imageKey points
The neural correlates of consciousness have evolved from global brain states to a nuanced interplay between global and local states, evident in terms of local sleep in awake brains and local wakefulness in sleeping brains.
The concept of local wakefulness remains unclear for general anaesthesia, where the loss of consciousness has been recently suggested to involve brain‐wide synchrony of layer 5 cortical neurons.
We found that local wakefulness‐like activity of layer 5 cortical can be chemogenetically induced in anaesthetised mice without affecting the depth of anaesthesia or the transitions to and from unconsciousness.
Global layer 5 synchrony may thus be a sufficient but not necessary feature for the unconsciousness induced by general anaesthesia.
Local wakefulness‐like activity of layer 5 neurons is compatible with general anaesthesia, thus promoting further investigation into the local vs. global aspects of anaesthesia‐induced unconsciousness.
Glyoxalase 1 overexpression improves neurovascular coupling and limits development of mild cognitive impairment in a mouse model of type 1 diabetes
Authors: Berends Eline , Pencheva Margarita G. , van de Waarenburg Marjo P. H. , Scheijen Jean L. J. M. , Hermes Denise J. H. P. , Wouters Kristiaan , van Oostenbrugge Robert J. , Foulquier Sébastien , Schalkwijk Casper G. 
Published: September 2024

AbstractDiabetes is associated with cognitive impairment, but the underlying mechanism remains unclear. Methylglyoxal (MGO), a precursor to advanced glycation endproducts (AGEs), is elevated in diabetes and linked to microvascular dysfunction. In this study, overexpression of the MGO‐detoxifying enzyme glyoxalase 1 (Glo1) was used in a mouse model of diabetes to explore whether MGO accumulation in diabetes causes cognitive impairment. Diabetes was induced with streptozotocin. Fasting blood glucose, cognitive function, cerebral blood flow, neurovascular coupling (NVC), Glo1 activity, MGO and AGEs were assessed. In diabetes, MGO‐derived hydroimidazolone‐1 increased in the cortex, and was decreased in Glo1‐overexpressing mice compared to controls. Visuospatial memory was decreased in diabetes, but not in Glo1/diabetes. NVC response time was slightly increased in diabetes, and normalised in the Glo1‐overexpressing group. No impact of diabetes or Glo1 overexpression on blood–brain barrier integrity or vascular density was observed. Diabetes induced a mild visuospatial memory impairment and slightly reduced NVC response speed and these effects were mitigated by Glo1. This study shows a link between MGO‐related AGE accumulation and cerebrovascular/cognitive functions in diabetes. Modulation of the MGO–Glo1 pathway may be a novel intervention strategy in patients with diabetes who have cerebrovascular complications.
imageKey points
Diabetes is associated with an increased risk of stroke, cognitive decline, depression and Alzheimer's disease, but the underlying mechanism remains unclear.
Methylglyoxal (MGO), a highly reactive by‐product of glycolysis, plays an important role in the development of diabetes‐associated microvascular dysfunction in the periphery and is detoxified by the enzyme glyoxalase 1.
Diabetes reduced visuospatial memory in mice and slowed the neurovascular coupling response speed, which was improved by overexpression of glyoxalase 1.
MGO formation and MGO‐derived advanced glycation endproduct (AGE) accumulation in the brain of diabetic mice are associated with a slight reduction in neurovascular coupling and mild cognitive impairment.
The endogenous formation of MGO, and the accumulation of MGO‐derived AGEs, might be a potential target in reducing the risk of vascular cognitive impairment in people with diabetes.
A Linear Method to Fit Equivalent Circuit Model Parameter Values to HPPC Relaxation Data From Lithium-Ion Cells
Authors: Plett Gregory L. 
Published: September 2024

Abstract
Battery management systems require mathematical models of the battery cells that they monitor and control. Commonly, equivalent circuit models are used. We would like to be able to determine the parameter values of their equations using simple tests and straightforward optimizations. Historically, it has appeared that nonlinear optimization is required to find the state-equation time constants. However, this article shows that the relaxation interval following a current or power pulse provides data that can be used to find these time constants using linear methods. After finding the time constants, the remaining parameter values can also be found via linear regression. Overall, only linear algebra is used to find all of the parameter values of the equivalent circuit model. This yields fast, robust, and simple implementations, and even enables application in an embedded system, such as a battery management system, desiring to retune its model parameter values as its cell ages.
An Approach to Realize Generalized Optimal Motion Primitives Using Physics Informed Neural Networks
Authors: Slightam Jonathon E. , Steyer Andrew J. , Beaver Logan E. , Young Carol C. 
Published: September 2024

Abstract
Autonomous manipulation is a challenging problem in field robotics due to uncertainty in object properties, constraints, and coupling phenomenon with robot control systems. Humans learn motion primitives over time to effectively interact with the environment. We postulate that autonomous manipulation can be enabled by basic sets of motion primitives as well, but do not necessitate mimicking human motion primitives. This work presents an approach to generalized optimal motion primitives using physics-informed neural networks. Our simulated and experimental results demonstrate that optimality is notionally maintained where the mean maximum observed final position percent error was 0.564% and the average mean error for all the trajectories was 1.53%. These results indicate that notional generalization is attained using a physics-informed neural network approach that enables near optimal real-time adaptation of primitive motion profiles.
FPSO Roll Motions Driven by Second-Order Forces and the Impacts on SLWR Riser Design
Authors: Senra Stael F. , Ferreira Marcos Donato A. S. , Oliveira Allan C. , Sena Bernardo D. , Prado Vinicius G. , Pesce Celso Pupo 
Published: September 2024

Abstract
The dynamic behavior of risers is highly influenced by the floating production unit (FPU) motions, associated with environmental loads, caused by waves, current, and wind. Particularly, as well known, under potential flow modeling, wave loads may be represented through power series expansions, with respect to a small parameter ε. First-order wave forces pulsate in the frequency range of the incident wave spectra, whereas second-order wave forces are related to sum or difference frequencies of the same spectra. The so-called second-order difference frequencies forces may then be responsible by resonating motions of the vessel in that range. Significant low-frequency motions due to second-order forces are commonly observed in the horizontal plane, resonating low natural frequencies of moored floating systems characterized by low mooring stiffnesses. Recently, however, this phenomenon was also observed for roll motions in several new floating production storage and offloading (FPSOs) that will operate in the pre-salt of Santos Basin. The phenomenon had already been detected in a deep draft semi-submersible in Campos Basin, but only more recently in FPSOs. The new floating units are characterized by high roll natural periods, above the typical wave period range in the pre-salt region, and the roll response to the second-order difference frequencies forces can be significant. This phenomenon was indeed detected in model tests and confirmed by numerical studies. In fact, this additional FPSO roll behavior occurs in typical periods slightly above 20 s, imposing displacements and accelerations that can directly affect the dynamics of the riser top region. The present paper addresses this phenomenon and its possible impact on steel lazy-wave riser (SLWR) designs.