bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted exome sequencing defines novel and rare variants in complex blood group serology cases for a red blood cell reference laboratory setting
Authors: Schoeman Elizna M. , Roulis Eileen V. , Liew Yew‐Wah , Martin Jacqueline R. , Powley Tanya , Wilson Brett , Millard Glenda M. , McGowan Eunike C. , Lopez Genghis H. , O'Brien Helen , Condon Jennifer A. , Flower Robert L. , Hyland Catherine A. 
Published: November 2017

BACKGROUNDWe previously demonstrated that targeted exome sequencing accurately defined blood group genotypes for reference panel samples characterized by serology and single‐nucleotide polymorphism (SNP) genotyping. Here we investigate the application of this approach to resolve problematic serology and SNP‐typing cases.STUDY DESIGN AND METHODSThe TruSight One sequencing panel and MiSeq platform was used for sequencing. CLC Genomics Workbench software was used for data analysis of the blood group genes implicated in the serology and SNP‐typing problem. Sequence variants were compared to public databases listing blood group alleles. The effect of predicted amino acid changes on protein function for novel alleles was assessed using SIFT and PolyPhen‐2.RESULTSAmong 29 unresolved samples, sequencing defined SNPs in blood group genes consistent with serologic observation: 22 samples exhibited SNPs associated with varied but known blood group alleles and one sample exhibited a chimeric RH genotype. Three samples showed novel variants in the CROM, LAN, and RH systems, respectively, predicting respective amino acid changes with possible deleterious impact. Two samples harbored rare variants in the RH and FY systems, respectively, not previously associated with a blood group allele or phenotype. A final sample comprised a rare variant within the KLF1 transcription factor gene that may modulate DNA‐binding activity.CONCLUSIONTargeted exome sequencing resolved complex serology problems and defined both novel blood group alleles (CD55:c.203G>A, ABCB6:c.1118_1124delCGGATCG, ABCB6:c.1656‐1G>A, and RHD:c.452G>A) and rare variants on blood group alleles associated with altered phenotypes. This study illustrates the utility of exome sequencing, in conjunction with serology, as an alternative approach to resolve complex cases.
Hobson‐Jobson: The East India Company lexicon
Authors: TELTSCHER KATE 
Published: November 2017

ABSTRACTHenry Yule and A.C. Burnell'sHobson‐Jobson: A Glossary of Colloquial Anglo‐Indian Words and Phrases(1886) offers a richly nuanced history of the East India Company. This article argues that the lexicon shows the influence of comparative philology, particularly the work of Friedrich Max Müller. Compiled at the same time as the India Office archives were first catalogued,Hobson‐Jobsonengages with the primary sources of Company history. The article examines both the impact of Asian words and goods on Britain, and the cultural and trading connections between colonies. Through a series of close readings, the article demonstrates thatHobson‐Jobsonoffers fresh ways to approach the global networks of Company trade, and personal networks of affiliation.
High conservation of the transcriptional response to acetolactate‐synthase‐inhibiting herbicides across plant species
Authors: Délye C , Duhoux A , Gardin J A C , Gouzy J , Carrère S 
Published: November 2017

SummaryWe investigated whether specific ALS‐inhibitor response marker‐genes (AIRMs) identified in the model dicotyledonous plant Arabidopsis thaliana (Brassicaceae) were conserved across phylogenetically very distant species. The most probable homologs of the 533 A. thalianaAIRMs were identified in the major monocotyledonous weeds Alopecurus myosuroides and Lolium sp. (Poaceae) using recently established transcriptome resources. Expression patterns of above 70% of the grass AIRMs homologs matched those of their A. thaliana counterparts. Pathways of response to acetolactate‐synthase (ALS)‐inhibiting herbicides seem therefore strongly conserved, even across very distant plant species. This opens new perspectives for unravelling the genetic determinants of non‐target‐site resistance (NTSR) to ALS inhibitors, especially those governing NTSR regulation that remains fully unknown to date. Model plants could be used in a first step to discover the genes involved in ALS‐inhibitor response pathways. Subsequent studies comparing sequence and expression of weed homologs of these genes should expedite the identification of candidates for the role of genes governing NTSR sensing and regulatory pathways.
Reviewer Acknowledgements
Authors: Gibbs Nikki 
Published: November 2017

Applied Economics and Finance (AEF) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether AEF publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 4, Number 5Asad K. Ghalib, Liverpool Hope University, UKAyoub Taha Sidahmed, SIU, SudanDilshodjon Rakhmonov, Tashkent State University of Economics, UzbekistanEncarnación Alvarez-Verdejo, University of Granada, SpainErdal Gumus, Eskisehir Osmangazi University, TurkeyEyup Kadioglu, Capital Markets Board, TurkeyGeorge Theocharides, Cyprus International Institute of Management, CyprusGetamesay Bekele Meshesha, Debre Berhan University, EthiopiaIbrahim Baghdadi, Lebanese University, LebanonIgor Matyushenko, School of Foreign Economic Relations and Touristic Business, UkraineLuca Giordano, IOSCO (International Organization of Securities Commissions), ItalyMagdalena Radulescu, University of Pitesti, RomaniaMasonic Lodge, TurkeyNicolas Afflatet, University of the Federal Armed Forces, GermanyNuno Crespo, ISCTEIUL, PortugalPatrycja Kowalczyk-Rolczynska, Wroclaw University of Economics, PolandPayal Chadha, University of Wales Prifysgol Cymru, KuwaitRomeo Victor Ionescu, Dunarea de Jos University, RomaniaRuhet GENC, Turkish-German University, TurkeySherry Jensen, Florida Institute of Technology, USASorin Gabriel Anton, Alexandru Ioan Cuza University of Iaşi, RomaniaSteven V. Cates, Kaplan University, USASzabolcs Blazsek, Universidad Francisco Marroquín, GuatemalaTaro Abe, Nagoya Gakuin University, JapanVictoria Cociug, Academy of Sciences of Moldova, MoldovaWing-Keung Wong, Asia University, TaiwanZi-Yi Guo, Wells Fargo Bank, N.A., USA Nikki GibbsEditorial AssistantOn behalf of,The Editorial Board of Applied Economics and FinanceRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://aef.redfame.com
Study of a Bioinspired Wall-Climbing Robot: Contact Mechanism and Performance
Authors: Wu Xuan , Liu Gaowei , Wang Xiaojie , Liu Yanwei , Mei Tao 
Published: November 2017

This paper presents a study of bioinspired wall-climbing robot (WCR) using spiny toes. The first part of the paper describes a design of a flexible spiny toe inspired by the features of a typical wall-climbing insect Serica orientalis Motschulsky’s tarsal system. A simple contact model of the spiny toe is proposed by considering the contact asperities as spheres. With the help of the finite element method (FEM), the stiffness matrices as well as the directional adhesive properties of the spiny toe are obtained. A single spiny toe and its array are fabricated via fast prototyping. The adhesive forces and pull-off positions of the single toe are measured with a homebuilt apparatus using displacement-control method under different compressive deformations. As for the spiny array, the effect of the dragging path on the adhesive forces is evaluated. The results show that, both the single toe and array exhibit directional adhesive features. The value of compressive deformation of the single toe influences the contacting angle, as a consequence the directional adhesive behavior is achieved. When forming an array with numerous spiny toes, the adhesive ability is strengthened, which is also affected by the random distribution of the surface asperity height.
In the second part of the paper, a prototype of bioinspired WCR is designed and fabricated based on a fully understanding of the spiny contact mechanism. The robot has two feet, each of which has spring-actuated gripper. An inchworm gait is generated according to the trajectory planning of the feet. Using the proposed spiny arrays, the robot archives scaling on vertical and inverted rough surfaces, and can also transition between vertical and ceiling walls. The performance of the prototype of bioinspired WCR shows promising in developing an intelligent and maneuverable WCR system in practical applications.
Wet-Adhesion Properties of Microstructured Surface of PDMS Inspired by Newt Foot Pads
Authors: Gong Ling , Yu Haiwu , Wu Xuan , Wang Xiaojie 
Published: November 2017

Newts display superior attachment and climbing abilities under wet conditions due to the distinct pattern of micro- and nanoscale structures (i.e., polygonal epidermal cells with raised boundaries, and dense nanopillar arrays) on their foot pad surfaces. Inspired by the surface features of newt foot pads, a microstructured surface consisting of structural elements of round pillars surrounded by a closed hexagonal ridge is produced on the polydimethylsiloxane (PDMS) elastomer, and its wet adhesion properties are studied experimentally. A homebuilt adhesion tester is developed to carry out the pull-off experiments, in which the adhesion force of samples can be measured directly. The PDMS sample is fixed on the substrate, and a flat glass cylinder of 10 mm diameter is adopted as indenter. Different amounts of liquid are added to the area of contact by using a micropipette. Influences of preload, retraction speed, area ratio of round pillars, amount of liquid and approach-retraction cycle on wet adhesion of the patterned surface of PDMS samples are investigated.
Results show that the pull-off forces of all samples increase with preload and retraction speed. However, the pull-off forces increase slowly when the preload is over 3 N for both dry and wet conditions. The area ratios of round pillars increase the pull-off forces for the dry condition. When a small amount of liquid (0.1 μl) is added, the effect of the area ratios of round pillars on the pull-off force is not consistent with that of dry condition. Effects of amount of liquid on pull-off force for different area ratios of round pillars are various. For a certain amount of liquid, it is observed that the pull-off forces in general show a relatively high value for the first approach-retraction cycle, then decrease to a lower level starting from the second cycle, and suddenly increase and maintain a relatively constant value after several times of approach-retraction cycles. Our results can give insights into the repeated sliding actions of newt foot pads when climbing in wet environments as well as the possible functions of dense nanopillar arrays on newt footpad surface.
Two Stage Design of Compliant Mechanisms With Superelastic Compliant Joints
Authors: Jovanova Jovana , Frecker Mary 
Published: November 2017

The design of compliant mechanisms made of Nickel Titanium (NiTi) Shape Memory Alloys (SMAs) is considered to exploit the superelastic behavior of the material to achieve tailored high flexibility on demand. This paper focuses on two-stage design optimization of compliant mechanisms, as a systematic method for design of the composition of the functionally graded NiTi material within the compliant mechanism devices. The location, as well as geometric and mechanical properties, of zones of high and low flexibility will be selected to maximize mechanical performance. The proposed two-stage optimization procedure combines the optimization of an analytical model of a single-piece functionally graded unit, with a detailed FEA of a continuous compliant mechanism.
In the first stage, a rigid-link model is developed to initially approximate the behavior of the compliant mechanism. In the second stage the solution of the rigid-link problem serves as the starting point for a continuous analytical model where the mechanism consists of zones with different material properties and geometry, followed by a detailed FEA of a compliant mechanism with integrated zones of superelasticity.
The two-stage optimization is a systematic approach for compliant mechanism design with functional grading of the material to exploit superelastic response in controlled manner. Direct energy deposition, as an additive manufacturing technology, is foreseen to fabricate assemblies with multiple single piece functional graded components. This method could be applied to bio-inspired structures, flapping wings, flexible adaptive structures and origami inspired compliant mechanisms.
Microsecond State Monitoring of Nonlinear Time-Varying Dynamic Systems
Authors: Dodson Jacob , Joyce Bryan , Hong Jonathan , Laflamme Simon , Wolfson Janet 
Published: November 2017

Reliable operation of next generation high-speed complex structures (e.g. hypersonic air vehicles, space structures, and weapons) relies on the development of microsecond structural health monitoring (μSHM) systems. High amplitude impacts may damage or alter the structure, and therefore change the underlying system configuration and the dynamic response of these systems. While state-of-the-art structural health monitoring (SHM) systems can measure structures which change on the order of seconds to minutes, there are no real-time methods for detection and characterization of damage in the microsecond timescales.
This paper presents preliminary analysis addressing the need for microsecond detection of state and parameter changes. A background of current SHM methods is presented, and the need for high rate, adaptive state estimators is illustrated. Example observers are tested on simulations of a two-degree of freedom system with a nonlinear, time-varying stiffness coupling the two masses. These results illustrate some of the challenges facing high speed damage detection.
Comparing a new hydroexpression technique with conventional forceps method for SMILE lenticule removal
Authors: Ng Alex L K , Cheng George P M , Woo Victor C P , Jhanji Vishal , Chan Tommy C Y 
Published: November 2017

BackgroundWe described a modified ‘hydroexpression’ technique for the lenticule removal during small-incision lenticule extraction (SMILE) surgery and compared the results with conventional forceps method.MethodsThis was a retrospective, comparative study of 50 patients who underwent SMILE surgery by the same surgeon. We compared the 1-week and 3-months postoperative results after SMILE using the hydroexpression technique with the conventional forceps technique. Main outcome measures included uncorrected distance visual acuity, corrected distance visual acuity, refractive accuracy, safety index and efficacy index.ResultsThe baseline characteristics were comparable between both groups. At postoperative 1 week, the safety index in forceps and hydroexpression group was 0.93±0.11 and 0.97±0.10, respectively (P=0.246). At 3 months, they were 1.00±0.06 and 0.99±0.09 (P=0.850). For efficacy indices, at 1 week they were 0.84±0.17 and 0.91±0.17 (P=0.158). At 3 months, they were 0.92±0.13 and 0.94±0.19 (P=0.624). All eyes aimed for a plano target. 96% in forceps group and 90% in hydroexpression group were within ±0.50 dioptre (D) in spherical equivalent refraction (SEQ) correction at postoperative 3 months (P=0.567). The mean errors of SEQ correction were −0.10±0.21 D in forceps group and −0.08±0.30 D in hydroexpression group (P=0.705).ConclusionHydroexpression was simple and safe and had early results comparable to the conventional forceps technique. This technique was particularly useful for cases with more adhesions between lenticule and anterior cap, thin lenticule cases and for the inexperienced SMILE surgeons.
Metagenomic deep sequencing of aqueous fluid detects intraocular lymphomas
Authors: Gonzales John , Doan Thuy , Shantha Jessica G , Bloomer Michele , Wilson Michael R , DeRisi Joseph L , Acharya Nisha 
Published: November 2017

IntroductionCurrently, the detection of pathogens or mutations associated with intraocular lymphomas heavily relies on prespecified, directed PCRs. With metagenomic deep sequencing (MDS), an unbiased high-throughput sequencing approach, all pathogens as well as all mutations present in the host’s genome can be detected in the same small amount of ocular fluid.MethodsIn this cross-sectional case series, aqueous fluid samples from two patients were submitted to MDS to identify pathogens as well as common and rare cancer mutations.ResultsMDS of aqueous fluid from the first patient with vitreal lymphoma revealed the presence of both Epstein-Barr virus (HHV-4/EBV) and human herpes virus 8 (HHV-8) RNA. Aqueous fluid from the second patient with intraocular B-cell lymphoma demonstrated a less common mutation in the MYD88 gene associated with B-cell lymphoma.ConclusionMDS detects pathogens that, in some instances, may drive the development of intraocular lymphomas. Moreover, MDS is able to identify both common and rare mutations associated with lymphomas.
Cohort profile: workers’ compensation in a changing Australian labour market: the return to work (RTW) study
Authors: Dimitriadis Christina , LaMontagne Anthony D , Lilley Rebbecca , Hogg-Johnson Sheilah , Sim Malcolm , Smith Peter 
Published: November 2017

PurposeWorkers’ compensation claims for older workers and workers who have suffered psychological injury are increasing as a proportion of total claims in many jurisdictions. In the Australian state of Victoria, claims from both these groups are associated with higher than average wage replacement and healthcare expenditures. This cohort profile describes a longitudinal study which aims to investigate differences in the return to work (RTW) process for older workers compared with younger workers and claimants with musculoskeletal injuries compared with those with psychological injuries.ParticipantsThis prospective cohort study involved interviewing workers’ compensation claimants at three time points. The cohort was restricted to psychological and musculoskeletal claims. Only claimants aged 18 and over were recruited, with no upper age limit. A total of 869 claimants completed the baseline interview, representing 36% of the eligible claimant population. Ninety-one per cent of participants agreed at baseline to have their survey responses linked to administrative workers’ compensation data. Of the 869 claimants who participated at baseline, 632 (73%) took part in the 6-month follow-up interview, and 572 (66%) participated in the 12-month follow-up interview.Findings to dateInformation on different aspects of the RTW process and important factors that may impact the RTW process was collected at the three survey periods. At baseline, participants and non-participants did not differ by injury type or age group, but were more likely to be female and from the healthcare and social assistance industry. The probability of non-participation at follow-up interviews showed younger age was a statistically significant predictor of non-participation.Future plansAnalysis of the longitudinal cohort will identify important factors in the RTW process and explore differences across age and injury type groups. Ongoing linkage to administrative workers’ compensation data will provide information on wage replacement and healthcare service use into the future.
Cohort profile: design and first results of the Dutch IBD Biobank: a prospective, nationwide biobank of patients with inflammatory bowel disease
Authors: Spekhorst Lieke M , Imhann Floris , Festen Eleonora AM , Bodegraven Ad A van , Boer Nanne KH de , Bouma Gerd , Fidder Herma H , D’Haens Geert , Hoentjen Frank , Hommes Daan W , Jong Dirk J de , Löwenberg Mark , Maljaars PW Jeroen , Meulen-de Jong Andrea E van der , Oldenburg Bas , Pierik Marieke J , Ponsioen Cyriel Y , Stokkers Pieter C , Verspaget Hein W , Visschedijk Marijn C , van der Woude C Janneke , Dijkstra Gerard , Weersma Rinse K 
Published: November 2017

PurposeThe Dutch IBD Biobank aims to facilitate the discovery of predictors for individual disease course and treatment response in patients with inflammatory bowel disease (IBD). In this paper, we aim to describe the establishment of the Dutch IBD Biobank, including the facilitators and barriers to establishment. Moreover, we aim to provide a complete overview of the content of the Dutch IBD Biobank.ParticipantsSince 2007, every patient with IBD treated in one of the eight Dutch university medical centres is asked to participate in the Dutch IBD Biobank in which 225 standardised IBD-related data items and biomaterials, such as serum, DNA, biopsies and a stool sample, are collected.Findings to dateAs of June 2014, the Dutch IBD Biobank had enrolled 3388 patients with IBD: 2118 Crohn’s disease (62.5%), 1190 ulcerative colitis (35.1%), 74 IBD-unclassified (2.2%) and 6 IBD-indeterminate (0.2%). The inclusion of patients with IBD is ongoing. The quality of the biomaterials is good and serum, DNA and biopsies have been used in newly published studies.Future plansThe genotyping (750 000 genetic variants) of all participants of the Dutch IBD Biobank is currently ongoing, enabling more genetic research. In addition, all participants will start reporting disease activity and outcome measures using an online platform and mobileapp.
Association of type 2 diabetes with in-hospital complications among women undergoing breast cancer surgical procedures. A retrospective study using the Spanish National Hospital Discharge Database, 2013–2014
Authors: Lopez-de-Andres Ana , Jimenez-Trujillo Isabel , Hernandez-Barrera Valentin , de Miguel-Diez Javier , Mendez-Bailon Manuel , de Miguel-Yanes Jose M , Perez-Farinos Napoleon , Salinero-fort Miguel Angel , del Barrio Jose L , Romero-Maroto Martin , Jimenez-Garcia Rodrigo 
Published: November 2017

ObjectivesTo compare the type of surgical procedures used, comorbidities, in-hospital complications (IHC) and in-hospital outcomes between women with type 2 diabetes mellitus (T2DM) and age-matched women without diabetes who were hospitalised with breast cancer. In addition, we sought to identify factors associated with IHC in women with T2DM who had undergone surgical procedures for breast cancer.DesignRetrospective study using the National Hospital Discharge Database, 2013–2014.SettingSpain.ParticipantsWomen who were aged ≥40 years with a primary diagnosis of breast cancer and who had undergone a surgical procedure. We grouped admissions by T2DM status. We selected one matched control for each T2DM case.Main outcome measuresThe type of procedure (breast-conserving surgery (BCS) or mastectomy), clinical characteristics, complications, length of hospital stay and in-hospital mortality.ResultsWe identified 41 458 admissions (9.23% with T2DM). Overall, and in addition to the surgical procedure, we found that comorbidity, hypertension and obesity were more common among patients with T2DM. We also detected a higher incidence of mastectomy in women with T2DM (44.69% vs 42.42%) and a greater rate of BCS in patients without T2DM (57.58% vs 55.31%). Overall, non-infectious complications were more common among women with T2DM (6.40% vs 4.56%). Among women who had undergone BCS or a mastectomy, IHC were more frequent among diabetics (5.57% vs 3.04% and 10.60% vs 8.24%, respectively). Comorbidity was significantly associated with a higher risk of IHC in women with diabetes, independent of the specific procedure used.provinceConclusionsWomen with T2DM who undergo surgical breast cancer procedures have more comorbidity, risk factors and advanced cancer presentations than matched patients without T2DM. Mastectomies are more common in women with T2DM. Moreover, the procedures among women with T2DM were associated with greater IHC. Comorbidity was a strong predictor of IHC in women with T2DM.