bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Further Step to Develop Patient-Friendly Implementation Strategies for Virtual Reality–Based Rehabilitation in Patients With Acute Stroke
Authors: Lee Minyoung , Pyun Sung-Bom , Chung Jinjoo , Kim Jungjin , Eun Seon-Deok , Yoon BumChul 
Published: May 2016

AbstractBackgroundVirtual reality (VR)–based rehabilitation is gaining attention as a way to promote early mobilization in patients with acute stroke. However, given the motor weakness and cognitive impairment associated with acute stroke, implementation strategies for overcoming patient-perceived difficulty need to be developed to enhance their motivation for training.ObjectiveThe purpose of this study was to explore patient-perceived difficulty and enjoyment during VR-based rehabilitation and the factors affecting those experiences.DesignAn exploratory mixed-method design was used in this study.MethodsEight individuals with acute stroke participated in 2 training modes of VR-based rehabilitation (ie, workout and game modes) 20 to 30 minutes per day for 5 to 8 sessions. A visual analog scale was used to assess patient-perceived difficulty and enjoyment at every session. Then semistructured interviews were conducted to explore the factors affecting those experiences.ResultsLevels of difficulty and enjoyment varied depending on the training mode and participants' phases of recovery. Five major factors were identified as affecting those varied experiences: (1) ease of following the directions, (2) experience of pain, (3) scores achieved, (4) novelty and immediate feedback, and (5) self-perceived effectiveness.ConclusionsLevels of difficulty and enjoyment during VR-based rehabilitation differed depending on the phases of recovery and training mode. Therefore, graded implementation strategies for VR-based rehabilitation are necessary for overcoming patient-perceived difficulty and enhancing enjoyment. Ease of following the directions might be best considered in the very early stage, whereas multisensory feedback may be more necessary in the later stage. Health professionals also should find a way for patients to avoid pain during training. Feedback, such as knowledge of results and performance, should be used appropriately.
Embolization of the choroidal artery in the treatment of cerebral arteriovenous malformations
Authors: Elkordy Alaa , Endo Hidenori , Sato Kenichi , Matsumoto Yasushi , Kondo Ryushi , Niizuma Kuniyasu , Endo Toshiki , Fujimura Miki , Tominaga Teiji 
Published: May 2016

OBJECTIVE
The anterior and posterior choroidal arteries are often recruited to supply arteriovenous malformations (AVMs) involving important paraventricular structures, such as the basal ganglia, internal capsule, optic radiation, lateral geniculate body, and medial temporal lobe. Endovascular embolization through these arteries is theoretically dangerous because they supply eloquent territories, are of small caliber, and lack collaterals. This study aimed to investigate the safety and efficacy of embolization through these arteries.

METHODS
This study retrospectively reviewed 13 patients with cerebral AVMs who underwent endovascular embolization through the choroidal arteries between 2006 and 2014. Embolization was performed as a palliative procedure before open surgery or Gamma Knife radiosurgery. Computed tomography and MRI were performed the day after embolization to assess any surgical complications. The incidence and type of complications and their association with clinical outcomes were analyzed.

RESULTS
Decreased blood flow was achieved in all patients after embolization. Postoperative CT detected no hemorrhagic complications. In contrast, postoperative MRI detected that 4 of the 13 patients (30.7%) developed infarctions: 3 patients after embolization through the anterior choroidal artery, and 1 patient after embolization through the lateral posterior choroidal artery. Two of the 4 patients in whom embolization was from the cisternal segment of the anterior choroidal artery (proximal to the plexal point) developed symptomatic infarction of the posterior limb of the internal capsule, 1 of whom developed morbidity (7.7%). The treatment-related mortality rate was 0%. Additional treatment was performed in 12 patients: open surgery in 9 and Gamma Knife radiosurgery in 3 patients. Complete obliteration was confirmed by angiography at the last follow-up in 10 patients. Recurrent bleeding from the AVMs did not occur in any of the cases during the follow-up period.

CONCLUSIONS
Ischemic complications are possible following the embolization of cerebral AVMs through the choroidal artery, even with modern neurointerventional devices and techniques. Although further study is needed, embolization through the choroidal artery may be an appropriate treatment option when the risk of surgery or radiosurgery is considered to outweigh the risk of embolization.
Patency of the posterior communicating artery following treatment with the Pipeline Embolization Device
Authors: Daou Badih , Valle-Giler Edison P. , Chalouhi Nohra , Starke Robert M. , Tjoumakaris Stavropoula , Hasan David , Rosenwasser Robert H. , Hebert Ryan , Jabbour Pascal 
Published: May 2016

OBJECTIVE
The Pipeline Embolization Device (PED) has become an effective treatment strategy for some cerebral aneurysms. Concerns regarding the patency of branch arteries have been raised. The objective of this study was to assess the patency of the posterior communicating artery (PCoA) following treatment of PCoA aneurysms using the PED.

METHODS
All patients with PCoA aneurysms treated with the PED who had angiographic follow-up were retrospectively identified. The patency of the PCoA at follow-up was evaluated by 2 authors who were not involved in the intervention. Univariate and multivariate analyses were performed to identify factors associated with the following: 1) PCoA patency versus no or diminished flow, and 2) PCoA patency and diminished flow versus PCoA occlusion.

RESULTS
Thirty patients with an angiographic follow-up of 6 months were included. Aneurysm obliteration was achieved in 25 patients (83.3%). The PCoA was patent in 7 patients (23.3%), had diminished flow in 7 patients (23.3%), and was occluded in 16 patients (53.3%). In the univariate analysis of outcome, there was a trend for aneurysms with incomplete occlusion, aneurysms not previously treated, those with presence of a fetal PCoA, and those with an artery coming from the aneurysm to have higher odds of the PCoA remaining patent. In univariate and multivariate analyses of factors associated with outcome, fetal PCoA and presence of an artery coming from the aneurysm were associated with the PCoA remaining open with or without diminished flow. No patients had symptoms related to PCoA occlusion.

CONCLUSIONS
Occlusion and diminished flow through the PCoA is common following PED treatment of PCoA aneurysms. However, it is clinically insignificant in most cases.
The metopic index: an anthropometric index for the quantitative assessment of trigonocephaly from metopic synostosis
Authors: Wang Joanna Y. , Dorafshar Amir H. , Liu Ann , Groves Mari L. , Ahn Edward S. 
Published: May 2016

OBJECTIVE
Because the metopic suture normally fuses during infancy, there are varying degrees of severity in head shape abnormalities associated with premature fusion. A method for the objective and reproducible assessment of metopic synostosis is needed to guide management, as current methods are limited by their reliance on aesthetic markers. The object of this study was to describe the metopic index (MI), a simple anthropometric cranial measurement. The measurements can be obtained from CT scans and, more importantly, from palpable cranial landmarks, and the index provides a rapid tool for evaluating patients in both pre- and postoperative settings.

METHODS
High-resolution head CT scans obtained in 69 patients (age range 0–24 months) diagnosed with metopic craniosynostosis were retrospectively reviewed. Preoperative 3D reconstructions were available in 15 cases, and these were compared with 3D reconstructions of 324 CT scans obtained in a control group of 316 infants (age range 0–24 months) who did not have any condition that might affect head size or shape and also in a subset of this group, comprising 112 patients precisely matched to the craniosynostosis patients with respect to age and sex. Postoperative scans were available and reviewed in 9 of the craniosynostosis patients at a mean time of 7.1 months after surgical repair. 3D reconstructions of these scans were matched with controls based upon age and sex.

RESULTS
The mean preoperative MI for patients with trigonocephaly was 0.48 (SD 0.05), significantly lower than the mean values of 0.57 (SD 0.04) calculated on the basis of all 324 scans obtained in controls (p < 0.001) and 0.58 (SD 0.04) for the subset of 112 age- and sex-matched controls (p < 0.001). For 7 patients with both pre- and postoperative CT scans available for evaluation, the mean postoperative MI was 0.55 (SD 0.03), significantly greater than their preoperative MIs (mean 0.48 [SD 0.04], p = 0.001) and comparable to the mean MI of the controls (p = 0.30). In 4 patients, clinically obtained postoperative MIs by caliper measurement were comparable to measurements derived from CT (p = 0.141).

CONCLUSIONS
The MI is a useful measurement of the severity of trigonocephaly in patients with metopic synostosis. This simple quantitative assessment can potentially be used in the clinical setting to guide preoperative evaluation, surgical repair, and postoperative degree of correction.
Hepatoprotective effect of <i>Helicanthus elastica</i>
Authors: Sunil Kumar K.N. , Rajakrishnan R. , Thomas J. , Reddy G. Aadinaath 
Published: May 2016

<p class="Abstract">Search for medicinal plants to treat liver disorders is an important research topic on herbs. Acute toxicity study is a prerequisite for safety and dose fixation for further pharmacological actions. In the present study, aqueous and 95% ethanolic extract of whole plant of <em>Helicanthus elastica</em> were subjected to acute oral toxicity. The aqueous and ethanolic extract revealed no observable changes in the rats up to the dose level of 2,000 mg /kg body weight. The extracts were then screened for paracetamol-induced hepatic injury at dose levels of 200 and 400 mg/kg body weight (1/10 and 1/5 LD<sub>50 </sub>based on toxicity study). The aqueous extract of whole plant of <em>H. elastica</em> was found to produce significant (p&lt;0.05) reversal of the paracetamol-induced changes in the measured biochemical and histopathological parameters at lower dose of 200 mg/kg which was found to be better than ethanol extract at the same dose level.</p><p class="Abstract"><strong>Video Clip:</strong></p><p class="Abstract"><a href="https://www.youtube.com/v/cO6HI1Kikxs">Acute toxicity study and others:</a> 5 min 38 sec</p><p> </p>
Chemostratigraphy of Sediments in Benin West -1, Benin Flank: Paleoenvironmental Implications
Authors: Odedede O. 
Published: May 2016

Chemostratigraphical study was carried out on sediments of Benin west -1 well in order to understand their paleoenvironmental setting and geochemical zonations. Six chemozones (CHM 1, CHM 2, CHM 3, CHM 4, CHM 5 and CHM 6) were recognized in the stratigraphic column. Sedimentological attributes and maxima peaks and / or fluctuating trends of Zn, SiO2, K2O, Sr adjudged CHM 3 zone as a potential lowstand systems tract. Synergy of sedimentological and chemostratigraphical fingerprints suggests a marine to distributary channel environment of deposition.
Water Pollution by Industrial Effluent and Phytoplankton Diversity of Shitalakhya River, Bangladesh
Authors: Islam S. M. D. , Huda M. E. 
Published: May 2016

The present study investigated the water quality of Shitalakhya River, phytoplankton abundance, diversity and the effect of pollutants on phytoplankton as well as the primary productivity. The water of the collected samples was mostly alkaline (7.01-8.2) and showed a wide range of variation in EC (1171-2700 ?S/cm), TDS (576-1345 mg/L), DO (0.92-2.7 mg/L), free-CO2 (15-31 mg/L), BOD (12.03-28.38 mg/L) and COD (101.2-109.2 mg/L). A total of 62 species were identified of which 9 belonged to Chlorophyceae, 11 Cyanophyceae, 14 Euglenophyceae and 28 Bacillariophyceae. Among all the members, Bacillariophyceae were found to be dominant and lowest of Chlorophyceae indicates that this group is more sensitive to the pollutants discharged by the industry.
Chemotaxis of Biofilm Producing <i>Pseudomonas</i> spp. towards Refined Petroleum Oil
Authors: Dutta S. , Singh P. 
Published: May 2016

The bioavailability of organic contaminants to the degrading bacteria is a major limitation to efficient bioremediation of sites contaminated with hydrophobic pollutants. Studies were conducted to analyze the presence of biodegrading bacteria on the sites of refinery and garage oil spills with abundance of hydrocarbons. Contaminated soils were collected from these rich hydrocarbon sites and bacteria were isolated from samples using regular bacterial media enriched with petroleum oil. These isolates were characterized for their efficiency to utilize refining petroleum oil as their energy source and then the most common isolate was characterized. Further investigations examine the formation of biofilm by naturally existing oil-degrading bacteria on refine petroleum oil degradation. Here also studied the abilities of these Pseudomonas strains to respond chemo tactically to refine petroleum oil. Microbial chemotaxis plays important role for formation of biofilm. 16S rDNA analysis of the best degrader was found to belong to the Pseudomonas species. Interestingly, one of the best isolates was found to be close to Pseudomonas aeruginosa family.
Studies of Antimicrobial Activity of 2',4',5'- and 2',3',4'-Trimethoxy Flavanones
Authors: Rahim A. , Ali R. , Islam A. 
Published: May 2016

2',4',5'- and 2',3',4'-trimethoxy flavanones have been synthesized starting with 2-hydroxyacetophone and substituted aldehyde. Antibacterial activities of the flavanones have been tested along with their corresponding chalcones against two human pathogenic bacteria (Streptococcus-b-haemolyticus and Klebsiella sp. (G-)). Antifungal activities of the flavanones have also been investigated against two plants pathogenic mold fungi (Rhizactonia solani Sclerotium rolfsii). The structures of the synthesized compounds have been characterized with the help of UV, IR and 1H NMR and 13C-NMR spectra. The antibacterial and antifungal screening were performed in vitro by the filter paper disc diffusion method and poisoned food technique. The flavanones showed antibacterial activity while no activity was observed to their corresponding chalcones against the tested bacteria. On the other hand, chalcones and their corresponding flavanones both showed fungicidal activities.
PHOSPHORUS-BEARING MOLECULES IN MASSIVE DENSE CORES*
Authors: Fontani F. , Rivilla V. M. , Caselli P. , Vasyunin A. , Palau A. 
Published: May 2016

ABSTRACT
Phosphorus is a crucial element for the development of life, but so far P-bearing molecules have been detected only in a few astrophysical objects; hence, its interstellar chemistry is almost totally unknown. Here, we show new detections of phosphorus nitride (PN) in a sample of dense cores in different evolutionary stages of the intermediate- and high-mass star formation process: starless, with protostellar objects, and with ultracompact H ii regions. All detected PN line widths are smaller than ≃5 km s−1, and they arise from regions associated with kinetic temperatures smaller than 100 K. Because the few previous detections reported in the literature are associated with warmer and more turbulent sources, the results of this work show that PN can arise from relatively quiescent and cold gas. This information is challenging for theoretical models that invoke either high desorption temperatures or grain sputtering from shocks to release phosphorus into the gas phase. Derived column densities are of the order of 1011–12 cm−2, marginally lower than the values derived in the few high-mass star-forming regions detected so far. New constraints on the abundance of phosphorus monoxide, the fundamental unit of biologically relevant molecules, are also given.
KIC 8462852 FADED AT AN AVERAGE RATE OF 0.164 ± 0.013 MAGNITUDES PER CENTURY FROM 1890 TO 1989
Authors: Schaefer Bradley E. 
Published: May 2016

ABSTRACT
KIC 8462852 is a completely ordinary F3 main-sequence star, except that the light curve from Kepler shows episodes of unique and inexplicable day-long dips with up to 20% dimming. Here, I provide a light curve of 1338 Johnson B-band magnitudes from 1890 to 1989 taken from archival photographic plates at Harvard. KIC 8462852 displays a secular dimming at an average rate of 0.164 ± 0.013 mag per century. From the early-1890s to the late-1980s, KIC 8462852 faded by 0.193 ± 0.030 mag. The decline is not an artifact because nearby check stars have closely flat light curves. This century-long dimming is unprecedented for any F-type main-sequence star. Thus, the Harvard light curve provides the first confirmation (past the several dips seen in the Kepler light curve alone) that KIC 8462852 has anything unusual. The century-long dimming and the day-long dips are both just extreme ends of a spectrum of timescales for unique dimming events. By Ockham’s Razor, two such unique and similar effects are very likely produced by one physical mechanism. This one mechanism does not appear as any isolated catastrophic event in the last century, but rather must be some ongoing process with continuous effects. Within the context of dust-occultation models, the century-long dimming trend requires 104–107 times as much dust as for the deepest Kepler dip. Within the context of the comet-family idea, the century-long dimming trend requires an estimated 648,000 giant comets (each with 200 km diameter) all orchestrated to pass in front of the star within the last century.
Total Hip Arthroplasty in 6690 Patients with Inflammatory Arthritis: Effect of Medical Comorbidities and Age on Early Mortality
Authors: Weiss Rüdiger J. , Garellick Göran , Kärrholm Johan , Hailer Nils P. 
Published: May 2016

Objective.We analyzed early mortality after total hip arthroplasty (THA) in patients with inflammatory arthritis (IA), adjusting for medical comorbidities and socioeconomic background.Methods.Data on 6690 patients with IA who underwent THA during 1992–2012 were extracted from the Swedish Hip Arthroplasty Register. Data on comorbidity, measured using the Charlson Comorbidity Index (CCI), and socioeconomic data were gathered from the Swedish National Inpatient Register and Statistics Sweden. The CCI was divided into low (0), moderate (1–2), and high (> 2). Cox proportional hazards models were fitted to calculate adjusted HR of early mortality, with 95% CI.Results.Twenty-five patients (0.4%) died within 0–90 days, giving a 90-day unadjusted survival rate of 99.6% (CI 99.5–99.8). Comorbidity was associated with an increased risk of death within 90 days postoperatively [high vs low CCI: adjusted HR 9.0 (CI 1.6–49.9)]. There was a trend toward lower risk of death during the period 1999–2005, although patients operated on during this period had more comorbidities than those operated on from 1992 to 1998. A large proportion of patients was re-admitted to hospital within 90 days after the index procedure (30.2%), but rarely for cardiovascular reasons.Conclusion.Medical comorbidity and an age above 75 years are associated with a substantial increase in the risk of early death after THA in patients with IA. Awareness of potential risk factors may alert clinicians and thus improve perioperative care.
Critical Care Nurses’ Knowledge of Confidentiality Legislation
Authors: Newman Angela B. , Kjervik Diane K. 
Published: May 2016

Background
Health care legislation can be difficult to understand and apply in critical situations where patients may not be physically capable of autonomous control of confidential health information. Nurses are often the first to encounter confidential information about patients.

Objectives
To explore critical care nurses’ knowledge of federal and North Carolina state legislation regarding confidentiality.

Methods
This descriptive, qualitative study included 12 critical care nurses who were asked to describe their knowledge of federal confidentiality legislation and specific knowledge of North Carolina’s confidentiality legislation.

Results
Critical care nurses were knowledgeable about federal confidentiality laws but demonstrated a need for further education about state-specific legislation.

Conclusion
Nurses’ application of confidentiality legislation demonstrates their knowledge of confidentiality legislation. To continue the trusting relationship that nurses have traditionally held with patients and patients’ families, it is imperative for nurses to remain current about confidentiality legislation. Through education both before and after licensure, correct application of legislation can be achieved. Further research can aid in exploring the intersection between health care legislation and ethics.
Underestimation of Pupil Size by Critical Care and Neurosurgical Nurses
Authors: Kerr Robert G. , Bacon Andrea M. , Baker Laura L. , Gehrke Janelle S. , Hahn K. Danielle , Lillegraven Cheryl L. , Renner Catherine Hackett , Spilman Sarah K. 
Published: May 2016

Background
Early detection of pupillary changes in patients with head injuries can alert the care team to increasing intracranial pressure. Previous research has shown inconsistencies in pupil measurement that are most likely due to the subjective nature of measuring pupils without the assistance of technology.

Objectives
To evaluate nurses’ abilities to assess pupil diameter accurately and detect unequal pupils.

Methods
In a 3-part study, the accuracy of critical care and neurosurgical nurses’ assessments of pupils was determined. The study included assessment of drawings of eyes with an iris and pupil, examination of photographs of human eyes, and bedside examination of patients with a head injury.

Results
Subjective assessments of pupil diameter and symmetry were not accurate. Across all phases of the study, pupil diameters were underestimated and the rate of error increased as pupil size increased. Nurses also failed to detect anisocoria and misidentified pupil reactivity. In addition, nearly all nurses relied on subjective estimation, even when tools were available.

Conclusions
Critical care and neurosurgical nurses underestimated pupil size, were unable to detect anisocoria, and incorrectly assessed pupil reactivity. Standardized use of pupil assessment tools such as a pupillometer is necessary to increase accuracy and consistency in pupil measurement and to potentially contribute to earlier detection of subtle changes in pupils. If pupillary changes are identified early, diagnostic and treatment intervention can be delivered in a more timely and effective manner.