bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiR‐148a promotes myocardial differentiation of human bone mesenchymal stromal cells via DNA methyltransferase 1 (DNMT1)
Authors: Jiang Changke , Gong Fang 
Published: June 2017

AbstractMicroRNAs have potential to modulate the differentiation of stem cells. In previous study, we found that miR‐148a was up‐regulated in myocardial differentiation of human bone mesenchymal stromal cells (hBMSCs) induced by 5′‐azacytidine. However, the role of miR‐148a in regulating this process still remains unclear. In this study, we investigated the function and molecular mechanism of miR‐148a in myocardial differentiation of hBMSCs. We found that miR‐148a was significantly increased while DNA methyltransferase 1 (DNMT1) was significantly decreased in myocardial differentiation of hBMSCs. Then, the dual luciferase reporter assays method indicated that DNMT1 was the direct target of miR‐148a. In addition, we showed that up‐regulation of miR‐148a could enhance myocardial differentiation of hBMSCs, while down‐regulation of miR‐148a could inhibit myocardial differentiation process. Moreover, knockdown of DNMT1 could block the role of miR‐148a in promoting myocardial differentiation of hBMSCs. Finally, MiR‐148a acted on methylation level of GATA‐4 and knockdown of DNMT1 could block this function. Therefore, our results indicate that miR‐148a plays a vital role in regulating myocardial differentiation of hBMSCs by targeting DNMT1.
Incidence, procedural management, and clinical outcomes of coronary in‐stent restenosis: Insights from the National VA CART Program
Authors: Waldo Stephen W. , O'Donnell Colin I. , Prouse Andrew , Plomondon Mary E. , Rao Sunil V. , Maddox Thomas M. , Ho P. Michael , Armstrong Ehrin J. 
Published: June 2017

AbstractBackroundIn‐stent restenosis (ISR) remains a common clinical problem associated with significant morbidity. We sought to evaluate the temporal trends in incidence and procedural management of coronary restenosis as well as evaluate the association between different treatment modalities and clinical outcomes.MethodsWe identified all patients treated for coronary ISR within the Veterans Affairs Healthcare System from October 1, 2006 to September 30, 2014. The temporal trends in incidence as well as intraprocedural management were assessed. Among patients treated for single vessel restenosis, a propensity matched cohort was created for those treated with drug‐eluting stents (DES) or other treatment modalities. Target vessel revascularization (TVR) and mortality were compared between the two subpopulations.ResultsFrom 2006 to 2014, 65,443 patients underwent percutaneous coronary intervention and 6,872 patients (10.5%) with 8,921 lesions were treated for ISR. The proportion of patients undergoing revascularization for restenosis increased 0.28% per year (P = 0.055). Among a propensity‐matched cohort of 6,231, the rates of TVR (subdistribution HR: 0.623, 95% CI: 0.511–0.760) and mortality (HR: 0.730, 95% CI: 0.641–0.830) were significantly lower among patients treated with a DES compared with other treatments. After adjustment for known risk factors, treatment with DES continued to be associated with a reduction in mortality rate (Adjusted HR: 0.802, 95% CI: 0.704–0.913).ConclusionsThere is a trend toward an increasing proportion of coronary interventions for ISR in a national cohort of Veterans and treatment with a DES is associated with the lowest rate of TVR and overall mortality.
A novel frameshift mutation of malonyl‐CoA decarboxylase deficiency: clinical signs and therapy response of a late‐diagnosed case
Authors: Ersoy Melike , Akyol Mehmet Bedir , Ceylaner Serdar , Çakır Biçer Nihan 
Published: June 2017

Key Clinical MessageWe evaluate the clinical findings and the treatment response of a late‐diagnosed case with a novel homozygous insertion c.13_14insG (p.P6Afs*202) result in a frameshift mutation in MLYCD gene. Both cardiac and neurologic involvements were mild when compared to previously reported cases, and see low‐fat/high‐carbohydrate diet treatment is highly effective.
Raman under Water: Nonlinear and Nearfield Approaches for Electrochemical Surface Science
Authors: Sabanés Natalia Martín , Domke Katrin F. 
Published: June 2017

AbstractThe front cover artwork is provided by the Domke group from the Max Planck Institute for Polymer Research. The image shows a cartoon association with Raman under water, depicting an underwater scene where molecule‐plants attached to nearfield‐generating particles are illuminated by a spotlight of a submarine and studied through a periscope. Read the full text of the Minireview at 10.1002/celc.201700293.
A DNA‐Based Encryption Method Based on Two Biological Axioms of DNA Chip and Polymerase Chain Reaction (PCR) Amplification Techniques
Authors: Zhang Yunpeng , Wang Zhiwen , Wang Zhenzhen , Liu Xin , Yuan Xiaojing 
Published: June 2017

AbstractResearchers have gained a deeper understanding of DNA‐based encryption and its effectiveness in enhancing information security in recent years. However, there are many theoretical and technical issues about DNA‐based encryption that need to be addressed before it can be effectively used in the field of security. Currently, the most popular DNA‐based encryption schemes are based on traditional cryptography and the integration of existing DNA technology. These schemes are not completely based on DNA computing and biotechnology. Herein, as inspired by nature, encryption based on DNA has been developed, which is, in turn, based on two fundamental biological axioms about DNA sequencing: 1) DNA sequencing is difficult under the conditions of not knowing the correct sequencing primers and probes, and 2) without knowing the correct probe, it is difficult to decipher precisely and sequence the information of unknown and mixed DNA/peptide nucleic acid (PNA) probes, which only differ in nucleotide sequence, arranged on DNA chips (microarrays). In essence, when creating DNA‐based encryption by means of biological technologies, such as DNA chips and polymerase chain reaction (PCR) amplification, the encryption method discussed herein cannot be decrypted, unless the DNA/PNA probe or PCR amplification is known. The biological analysis, mathematical analysis, and simulation results demonstrate the feasibility of the method, which provides much stronger security and reliability than that of traditional encryption methods.
Scaling Wet Fine Grinding Processes of Organic Particles Using Stirred Media Mills
Authors: Flach Frederik , Breitung‐Faes Sandra , Kwade Arno 
Published: June 2017

AbstractThis study presents an approach to scale up wet fine grinding processes of organic particles using stirred media mills. The process transfer is based on the calculation of grinding‐relevant energy, which is transferred to the product by a model theory derived from mill‐related values, especially geometric aspects. Its application was demonstrated by experimental work with two organic products, which were ground with different sizes and geometries of mills reaching from 20 to 900 mL grinding chamber volume under variation of process parameters.
Molecular Mechanism of Swing Effect in Zeolitic Imidazolate Framework ZIF‐8: Continuous Deformation upon Adsorption
Authors: Coudert François‐Xavier 
Published: June 2017

AbstractZeolitic imidazolate framework ZIF‐8 displays flexibility of its structure by rotation of its imidazolate linker. This “swing effect” has been widely described in the literature, both experimentally and theoretically, as a bistable system where the linker oscillates between two structures: “open window” and “closed window”. By using quantum chemistry calculations and first‐principles molecular dynamics simulations, it is shown that the deformation upon adsorption is in fact continuous upon pore loading, with thermodynamics of packing effects being the reason behind stepped adsorption isotherms experimentally observed. Finally, we study a variant of ZIF‐8 with a different linker, highlighting the influence of the linker and the balance of microscopic interactions on the framework's flexibility.
Convection‐Diffusion Layer in an “Open Space” for Local Surface Treatment and Microfabrication using a Four‐Aperture Microchemical Pen
Authors: Mao Sifeng , Zhang Yong , Zhang Weifei , Zeng Hulie , Nakajima Hizuru , Lin Jin‐Ming , Uchiyama Katsumi 
Published: June 2017

AbstractA four‐aperture microchemical pen was used to produce a stable convection‐diffusion layer in an “open space” for microreactions and microfabrication. The process represents a new method for microreactions and microfabrication in a convection‐diffusion layer. To prove the concept of a convection‐diffusion layer in an “open space”, bovine serum albumin was labeled with 4‐fluoro‐7‐nitro‐2,1,3‐benzoxadiazole to confirm that the small convection‐diffusion layer was effective for local surface treatment. To demonstrate the potential for microfabrication, silver patterns were fabricated on a glass surface with a convection‐diffusion layer by using the silver‐mirror reaction. The widths of each silver pattern could be easily controlled from 10 to 60 μm. Patterned silver lines with uniform widths or gradient widths were prepared. This is the first proof of concept study of a convection‐diffusion layer in an “open space” used in local surface treatment and microfabrication on a surface. The microchemical pen represents a potential method for the region‐selective microtreatment of tissues, cells, and other biological interfaces.
Measurements and characterization of power transformer and low voltage access network for NB‐PLC
Authors: Masood Bilal , Usman Muhammad , Gul Muhammad Usman , Khan Waheed Aftab 
Published: June 2017

SummarySeveral techniques for a state‐of‐the‐art advanced metering infrastructure (AMI) within the smart grid are being extensively studied and evaluated around the world. Advanced metering infrastructure provides an enhanced and efficient energy management infrastructure that can facilitate the latest demands of electric utilities, consumers, and smart grid. In the past few years, standardization process for the implementation of AMI using narrowband power line communications (NB‐PLC) transceivers has been completed by ITU‐T and IEEE. This paper is focused on the utilization of CENELEC band of NB‐PLC for deployment aspects. The power transformer model of 200 and 75 kVA transformers for 9 to 90 kHz frequency range that lies in CENELEC‐A band of NB‐PLC is also proposed. The proposed model is more simple than previously presented models in the literature and has the capability to evaluate the transformers working not only under normal condition but also under resonance condition for frequency of interest. Moreover, the efficient procedure for field measurements that provides a generalized NB‐PLC channel model for low voltage access network to deploy AMI within Lahore, Pakistan, is presented. A Simulink model is developed to validate the results. The analysis of measured and simulated results illustrates a close agreement of channel transfer functions. This research work proposes an improved and more accurate NB‐PLC channel model especially for South Asian countries.
Determination of testosterone esters in the hair of male greyhound dogs using liquid chromatography–high resolution mass spectrometry
Authors: Devi Jayasree Leela , Zahra Paul , Vine John H. , Whittem Ted 
Published: June 2017

The doping of greyhound dogs with testosterone is done in an attempt to improve their athletic performance, but such doping cannot easily be confirmed, especially in male dogs owing to the natural presence of endogenous testosterone. As testosterone is usually administered as its esters, their direct detection in hair would provide confirmatory evidence of the administration of a pharmaceutical product. This article demonstrates that the use of a liquid chromatography–high resolution mass spectrometry method with heated electrospray ionisation (HESI) combined with the use of amino solid‐phase extraction (SPE) cartridges for sample clean‐up, is suitable for the sensitive determination of propionate, phenyl propionate, isocaproate, decanoate, and enanthate esters of testosterone in greyhound hair. The method is linear over the range, 0.1 μg/kg–10 μg/kg, for all the testosterone esters analysed. The limits of detection (LOD) are 0.05 μg/kg for testosterone phenyl propionate, isocaproate, and decanoate, 0.025 μg/kg for testosterone propionate, and 0.25 μg/kg for testosterone enanthate. This method was applied to hair samples collected from male greyhounds before and after a single administration of a product containing several testosterone esters, each of which could be detected up to 100 days post‐administration. The study also demonstrates that tail hair is the specimen of choice for the analysis of testosterone in dog hair and that washing of dogs does not impact the analysis of testosterone esters in hair. This method may be useful in racing regulation for the detection of illegitimate use of testosterone in all species.
Exploring the key drivers of riparian woodland successional pathways across three European river reaches
Authors: Muñoz‐Mas R. , Garófano‐Gómez V. , Andrés‐Doménech I. , Corenblit D. , Egger G. , Francés F. , Ferreira M.T. , García‐Arias A. , Politti E. , Rivaes R. , Rodríguez‐González P.M. , Steiger J. , Vallés‐Morán F.J. , Martínez‐Capel F. 
Published: June 2017

AbstractClimate change and river regulation are negatively impacting riparian vegetation. To evaluate these impacts, process‐based models are preferred over data‐driven approaches. However, they require extensive knowledge about ecohydrological processes. To facilitate the implementation of such process‐based models, the key drivers of riparian woodland successional pathways across three river reaches, in Austria, Portugal, and Spain, were explored, employing two complementary approaches. The principal component analyses highlighted the importance of the physical gradients determining the placement of the succession phases within the riparian and floodplain zones. The generalized additive models revealed that the initial and pioneer succession phases, characteristic of the colonization stage, appeared in areas highly morphodynamic, close in height and distance to the water table, and with coarse substrate, whereas elder phases within the transitional and mature stages showed incremental differences, occupying less dynamic areas with finer substrate. The Austrian site fitted well the current successional theory (elder phases appearing sequentially further up and distant), but at the Portuguese site, the tolerance of the riparian species to drought and flash flood events governed their placement. Finally, at the Spanish site, the patchy distribution of the elder phases was the remnants of formative events that reshaped the river channel. These results highlight the complex relationships between flow regime, channel morphology, and riparian vegetation. The use of succession phases, which rely on the sequential evolution of riparian vegetation as a response to different drivers, may be potentially better reproducible, within numerical process‐based models, and transferable to other geographical regions.
Optimized Design Principles for Silicon‐Coated Nanostructured Electrode Materials and their Application in High‐Capacity Lithium‐Ion Batteries
Authors: Auer Andrea , Jonasson Niko Sebastian Willem , Apaydin Dogukan Hazar , Mardare Andrei Ionut , Neri Giulia , Lichtinger Josef , Gernhäuser Roman , Kunze‐Liebhäuser Julia , Portenkirchner Engelbert 
Published: June 2017

AbstractSilicon is considered as one of the most promising electrode materials for next‐generation, high‐energy‐density Li‐ion batteries as it demonstrates an exceptionally high specific capacity an order of magnitude beyond that of conventional graphite. The poor capacity retention, caused by the mechanical fracturing of Si because of the extreme volumetric and structural changes upon Li insertion/extraction, has triggered significant attention in the development of Si‐coated nanostructures that can accommodate the lithiation‐induced strain. In parallel, various spectroscopic studies and simulations have been conducted to understand the details of volumetric expansion, fracture, mechanical stress evolution, and structural changes in Si‐coated nanostructures. This publication reports a systematic lithiation/delithiation study of Si‐coated, anodically grown, self‐organized TiO2 nanotubes with different Si‐layer thicknesses. It is demonstrated for the first time that a “sweet spot” for the Si‐coating thickness is formed at which the specific lithiation capacity of the composite material reaches its maximum, which declines quickly for higher coating thicknesses. Furthermore, our results suggest that such a Si‐thickness‐dependent optimum in the specific lithiation capacity is immanent to any Si‐coated nanostructured electrode.
Accommodating missingness in environmental measurements in gene‐environment interaction analysis
Authors: Wu Mengyun , Zang Yangguang , Zhang Sanguo , Huang Jian , Ma Shuangge 
Published: June 2017

ABSTRACTFor the prognosis of complex diseases, beyond the main effects of genetic (G) and environmental (E) factors, gene‐environment (G‐E) interactions also play an important role. Many approaches have been developed for detecting important G‐E interactions, most of which assume that measurements are complete. In practical data analysis, missingness in E measurements is not uncommon, and failing to properly accommodate such missingness leads to biased estimation and false marker identification. In this study, we conduct G‐E interaction analysis with prognosis data under an accelerated failure time (AFT) model. To accommodate missingness in E measurements, we adopt a nonparametric kernel‐based data augmentation approach. With a well‐designed weighting scheme, a nice “byproduct” is that the proposed approach enjoys a certain robustness property. A penalization approach, which respects the “main effects, interactions” hierarchy, is adopted for selection (of important interactions and main effects) and regularized estimation. The proposed approach has sound interpretations and a solid statistical basis. It outperforms multiple alternatives in simulation. The analysis of TCGA data on lung cancer and melanoma leads to interesting findings and models with superior prediction.
Neural correlates of atomoxetine improving inhibitory control and visual processing in Drug‐naïve adults with attention‐deficit/hyperactivity disorder
Authors: Fan Li‐Ying , Chou Tai‐Li , Gau Susan Shur‐Fen 
Published: June 2017

AbstractAtomoxetine improves inhibitory control and visual processing in healthy volunteers and adults with attention‐deficit/hyperactivity disorder (ADHD). However, little is known about the neural correlates of these two functions after chronic treatment with atomoxetine. This study aimed to use the counting Stroop task with functional magnetic resonance imaging (fMRI) and the Cambridge Neuropsychological Test Automated Battery (CANTAB) to investigate the changes related to inhibitory control and visual processing in adults with ADHD. This study is an 8‐week, placebo‐controlled, double‐blind, randomized clinical trial of atomoxetine in 24 drug‐naïve adults with ADHD. We investigated the changes of treatment with atomoxetine compared to placebo‐treated counterparts using the counting Stroop fMRI and two CANTAB tests: rapid visual information processing (RVP) for inhibitory control and delayed matching to sample (DMS) for visual processing. Atomoxetine decreased activations in the right inferior frontal gyrus and anterior cingulate cortex, which were correlated with the improvement in inhibitory control assessed by the RVP. Also, atomoxetine increased activation in the left precuneus, which was correlated with the improvement in the mean latency of correct responses assessed by the DMS. Moreover, anterior cingulate activation in the pre‐treatment was able to predict the improvements of clinical symptoms. Treatment with atomoxetine may improve inhibitory control to suppress interference and may enhance the visual processing to process numbers. In addition, the anterior cingulate cortex might play an important role as a biological marker for the treatment effectiveness of atomoxetine. Hum Brain Mapp 38:4850–4864, 2017. © 2017 Wiley Periodicals, Inc.
An insight into the deep web; why it matters for addiction psychiatry?
Authors: Orsolini Laura , Papanti Duccio , Corkery John , Schifano Fabrizio 
Published: June 2017

AbstractObjectiveNowadays, the web is rapidly spreading, playing a significant role in the marketing or sale or distribution of “quasi” legal drugs, hence facilitating continuous changes in drug scenarios. The easily renewable and anarchic online drug‐market is gradually transforming indeed the drug market itself, from a “street” to a “virtual” one, with customers being able to shop with a relative anonymity in a 24‐hr marketplace. The hidden “deep web” is facilitating this phenomenon. The paper aims at providing an overview to mental health's and addiction's professionals on current knowledge about prodrug activities on the deep web.MethodsA nonparticipant netnographic qualitative study of a list of prodrug websites (blogs, fora, and drug marketplaces) located into the surface web was here carried out. A systematic Internet search was conducted on Duckduckgo® and Google® whilst including the following keywords: “drugs” or “legal highs” or “Novel Psychoactive Substances” or “NPS” combined with the word deep web.ResultsFour themes (e.g., “How to access into the deepweb”; “Darknet and the online drug trading sites”; “Grams‐search engine for the deep web”; and “Cryptocurrencies”) and 14 categories were here generated and properly discussed.ConclusionsThis paper represents a complete or systematical guideline about the deep web, specifically focusing on practical information on online drug marketplaces, useful for addiction's professionals.