bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring LOD through metadata extraction and data-driven visualizations
Authors: Peña Oscar , Aguilera Unai , López-de-Ipiña Diego 
Published: June 2016

Purpose
– The purpose of this paper is to present a new approach toward automatically visualizing Linked Open Data (LOD) through metadata analysis.

Design/methodology/approach
– By focussing on the data within a LOD dataset, the authors can infer its structure in a much better way than current approaches, generating more intuitive models to progress toward visual representations.

Findings
– With no technical knowledge required, focussing on metadata properties from a semantically annotated dataset could lead to automatically generated charts that allow to understand the dataset in an exploratory manner. Through interactive visualizations, users can navigate LOD sources using a natural approach, in order to save time and resources when dealing with an unknown resource for the first time.

Research limitations/implications
– This approach is suitable for available SPARQL endpoints and could be extended for resource description framework dumps loaded locally.

Originality/value
– Most works dealing with LOD visualization are customized for a specific domain or dataset. This paper proposes a generic approach based on traditional data visualization and exploratory data analysis literature.
Strategies for successful telework: how effective employees manage work/home boundaries
Authors: Basile Kelly A. , Beauregard T. Alexandra 
Published: June 2016

Purpose
This paper aims to identify strategies used by successful teleworkers to create and maintain boundaries between work and home, and to determine how these strategies relate to employee preferences for segmentation or integration of work and home.

Design/methodology/approach
Forty in-depth, face-to-face interviews were conducted with employees working from home either occasionally (occasional teleworkers), between 20 and 50 per cent of the workweek (partial teleworkers), or the majority of the time (full teleworkers).

Findings
Teleworkers use physical, temporal, behavioral and communicative strategies to recreate boundaries similar to those found in office environments. Although teleworkers can generally develop strategies that align boundaries to their preferences for segmentation or integration, employees with greater job autonomy and control are better able to do so.

Research limitations/implications
A limitation of this research is its potential lack of generalizability to teleworkers in organizations with “always-on” cultures, who may experience greater pressure to allow work to permeate the home boundary.

Practical implications
These findings can encourage organizations to proactively assess employee preferences for boundary permeability before entering a teleworking arrangement. The boundary management tactics identified can be used to provide teleworkers struggling to establish comfortable boundaries with tangible ideas to regulate interactions between home and work.

Originality/value
This research makes a significant contribution to practitioner literature by applying a boundary management framework to the practice of teleworking, which is being adopted by organizations with increasing frequency.
Model‐based exposure‐response analysis to quantify age related differences in the response to scopolamine in healthy subjects
Authors: Alvarez‐Jimenez Ricardo , Groeneveld Geert Jan , van Gerven Joop M. A. , Goulooze Sebastiaan C. , Baakman Anne Catrien , Hay Justin L. , Stevens Jasper 
Published: June 2016

AimSubjects with increasing age are more sensitive to the effects of the anti‐muscarinic agent scopolamine, which is used (among other indications) to induce temporary cognitive dysfunction in early phase drug studies with cognition enhancing compounds. The enhanced sensitivity has always been attributed to incipient cholinergic neuronal dysfunction, as a part of the normal aging process. The aim of the study was to correlate age‐dependent pharmacodynamic neuro‐physiologic effects of scopolamine after correcting for differences in individual exposure.MethodsWe applied a pharmacokinetic and pharmacodynamic modelling approach to describe individual exposure and neurocognitive effects of intravenous scopolamine administration in healthy subjects.ResultsA two‐compartment linear kinetics model best described the plasma concentrations of scopolamine. The estimated scopolamine population mean apparent central and peripheral volume of distribution was 2.66 ± 1.050 l and 62.10 ± 10.100 l, respectively and the clearance was 1.09 ± 0.096 l min−1. Age was not related to a decrease of performance in the tests following scopolamine administration in older subjects. Only the saccadic peak velocity showed a positive correlation between age and sensitivity to scopolamine. Age was, however, correlated at baseline with an estimated slower reaction time while performing the cognitive tests and to higher global δ and frontal θ frequency bands measured with the surface EEG.ConclusionsMost of the differences in response to scopolamine administration between young and older subjects could be explained by pharmacokinetic differences (lower clearance) and not to an enhanced sensitivity when corrected for exposure levels.
Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure
Authors: Stirrat Colin G. , Venkatasubramanian Sowmya , Pawade Tania , Mitchell Andrew J. , Shah Anoop S. , Lang Ninian N. , Newby David E. 
Published: June 2016

AimsUrocortin 2 and urocortin 3 may play a role in the pathophysiology of heart failure and are emerging therapeutic targets. We aimed to examine the local and systemic cardiovascular effects of urocortin 2 and urocortin 3 in healthy subjects and patients with heart failure.MethodsPatients with heart failure (n = 8) and age and gender‐matched healthy subjects (n = 8) underwent bilateral forearm arterial blood flow measurement using forearm venous occlusion plethysmography during intra‐arterial infusions of urocortin 2 (3.6–36 pmol min−1), urocortin 3 (360–3600 pmol min−1) and substance P (2–8 pmol min−1). Heart failure patients (n = 9) and healthy subjects (n = 7) underwent non‐invasive impedance cardiography during incremental intravenous infusions of sodium nitroprusside (573–5730 pmol kg−1 min−1 ), urocortin 2 (36–360 pmol min−1 ), urocortin 3 (1.2–12 nmol min−1) and saline placebo.ResultsUrocortin 2, urocortin 3 and substance P induced dose‐dependent forearm arterial vasodilatation in both groups (P < 0.05 for both) with no difference in magnitude of vasodilatation between patients and healthy subjects. During systemic intravenous infusions, urocortin 3 increased heart rate and cardiac index and reduced mean arterial pressure and peripheral vascular resistance index in both groups (P < 0.01 for all). Urocortin 2 produced similar responses to urocortin 3, although increases in cardiac index and heart rate were only significant in heart failure (P < 0.05) and healthy subjects (P < 0.001), respectively.ConclusionUrocortins 2 and 3 cause vasodilatation, reduce peripheral vascular resistance and increase cardiac output in both health and disease. These data provide further evidence to suggest that urocortins 2 and 3 continue to hold promise for the treatment of heart failure.
Neonatal adverse drug reactions: an analysis of reports to the French pharmacovigilance database
Authors: Kaguelidou Florentia , Beau‐Salinas Frédérique , Jonville‐Bera Annie Pierre , Jacqz‐Aigrain Evelyne 
Published: June 2016

AimTerm and preterm neonates are at high risk for serious adverse drug reactions (ADRs).MethodsA descriptive study of reports registered in the French pharmacovigilance database from 1986 to 2012 were obtained. All reports concerning neonates (≤1 month of life) with direct drug exposure were retrieved. Characteristics of the reports, including reported ADR(s), drug(s) and the causality assessment using the French causality assessment method, were described.ResultsA total of 1688 reports were analyzed and more than half of them were classified as serious (n = 995). Median age at ADR occurrence was 9 days. Overall, 3127 ADRs were described in these reports in relation to 2238 suspect/interacting drugs. The most commonly reported system organ classes (SOCs) were injury, poisoning and procedural complications (16%), general disorders and administration site conditions (12.5%) and blood and lymphatic system disorders (12%). In the majority of ADRs reported (73%), infants fully recovered and less than 4% of neonates deceased as a consequence of the reported ADR. One out of five ADRs was associated with drug administration errors. Therapeutic classes commonly incriminated were anti‐infectives, nervous system and alimentary tract drugs. Substances most frequently related to serious ADRs were zidovudine, ibuprofen and nevirapine. Among the 10 most frequently encountered drug−ADR pairs, two substances were mainly implicated, zidovudine in haematological adverse reactions and phytomenadione in maladministrations.ConclusionsAnti‐infective drugs, mainly antiretroviral therapy, account for the majority of ADRs reported in neonates. The specific issue of drug maladministration and medication errors remains to be addressed in neonates.
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents
Authors: Tsatsos Michael , MacGregor Cheryl , Athanasiadis Ioannis , Moschos Marilita M , Hossain Parwez , Anderson David 
Published: June 2016

AbstractOphthalmic herpes simplex viral keratitis is responsible for a range of ocular manifestations from superficial epithelial disease to stromal keratitis and endotheliitis. The Herpetic Eye Disease Study has guided the management of herpetic eye disease for almost twenty years, but newer medications such as valacyclovir are now available and are considered to have better bioavailability than acyclovir. In this review, we examine the existing evidence on the pathogenesis of different ophthalmic herpes simplex viral keratitis disease modalities and the role of oral and topically administered antiviral drugs in the treatment of herpes simplex viral keratitis.
Cartilage‐hair hypoplasia associated with isolated hypoganglionosis: A case report
Authors: Yasui Yoshitomo , Kohno Miyuki , Nishida Syouichi , Shironomae Tsubasa , Satomi Miwa , Kuwahara Tsuyoshi , Takahashi Sadayoshi , Niida Yo 
Published: June 2016

AbstractCartilage‐hair hypoplasia is a rare metaphyseal chondrodysplasia characterized by diverse clinical manifestations and a high incidence of Hirschsprung disease. We present a male patient with cartilage‐hair hypoplasia associated with severe intestinal obstruction. Genetic analysis of ribonuclease mitochondrial RNA‐processing complex gene identified compound heterozygous mutations consisted with previously reported mutations: n.‐14_3dupGAAGCTGAGGACGTGGT and n.183G > T. First, we considered that intestinal obstruction was due to an extensive type of Hirschsprung disease, but it was later confirmed as isolated hypoganglionosis. Isolated hypoganglionosis is rare and its therapeutic strategies are not well established. In cases of cartilage‐hair hypoplasia associated with severe intestinal obstruction, the differential diagnosis of not only Hirschsprung disease, but also isolated hypoganglionosis, should be considered.
Is genome size of Lepidoptera linked to host plant range?
Authors: Calatayud P.‐A. , Petit C. , Burlet N. , Dupas S. , Glaser N. , Capdevielle‐Dulac C. , Le Ru B. , Jacquin‐Joly E. , Kaiser‐Arnauld L. , Harry M. , Vieira C. 
Published: June 2016

AbstractGenome size varies considerably among organisms, largely as the result of differences in the content of non‐coding and/or repetitive DNA, such as introns, pseudogenes, or transposable elements, as well as whole‐genome duplications. Genome size is known to correlate with metabolic rates. Because polyphagy also affects the metabolism, a correlation between diet specialization and genome size can be expected. To test this hypothesis, a study was undertaken with five closely related species of stem borers which are easy to rear under artificial conditions, namely Busseola fusca (Fuller), Busseola segeta (Bowden), Busseola nairobica Le Ru, Sesamia calamistis Hampson, and Sesamia nonagrioides Lefebvre (all Lepidoptera: Noctuidae). However, as the number of species was too low for correlating diet with genome size in Lepidoptera in general, literature data from 16 Lepidoptera species were used in addition. The results pointed to a relationship between genome size and the insect's host plant range in Lepidoptera, but below the family level only, with larger genomes in polyphagous compared to specialist species. In addition, the genome size appeared to be influenced not only by host plant range but also by environmental/climatic conditions. Studies to test this hypothesis should be done strictly below the family level.
Carbon emission along a eutrophication gradient in temperate riverine wetlands: effect of primary productivity and plant community composition
Authors: Grasset Charlotte , Abril Gwenaël , Guillard Ludovic , Delolme Cécile , Bornette Gudrun 
Published: June 2016

Summary

Eutrophication increases primary productivity and favours the predominance of floating vegetation in wetlands. Carbon (C) fluxes in wetlands are strongly driven by primary productivity and can differ by vegetation type. However, to the best of our knowledge, the role of eutrophication in C fluxes has rarely been assessed.

Consequently, we aimed to measure the seasonal variation in carbon dioxide (CO2) and methane (CH4) fluxes at six aquatic sites in four temperate wetlands, ranging along a gradient of sediment total phosphorus content, and determine whether C fluxes correlate with above‐ground net primary productivity (ANPP) and plant community composition along this eutrophication gradient.

Daytime CO2 emissions were significantly and negatively correlated with wetland net primary productivity as a result of the greater C fixation by photosynthesis during the peak of production. Conversely, CH4 emissions were significantly and positively correlated with wetland ANPP, possibly due to higher litter production and anaerobic decomposition.

The highest CH4 emissions were observed above floating vegetation, which favoured hypoxic conditions in the water column. CH4 emissions including ebullition were higher above macroalgal belts than above vascular plants with floating leaves. CH4 emissions without ebullition (i.e. resulting from plant transport and diffusion) better correlated with the abundance of macroalgae than with the abundance of vascular plants with floating leaves.

Our results suggest that eutrophication may greatly modify CO2 and CH4 emissions from wetlands through changes in vegetation type and productivity.
Efficacy of XP‐endo finisher files in the removal of calcium hydroxide paste from artificial standardized grooves in the apical third of oval root canals
Authors: Wigler R. , Dvir R. , Weisman A. , Matalon S. , Kfir A. 
Published: June 2016

AbstractAimTo compare the efficacy of the XP‐endo finisher file (XP) (FKG Dentaire, La Chaux de Fonds, Switzerland) to that of passive ultrasonic irrigation (PUI) and conventional syringe and needle irrigation (SNI) in the removal of calcium hydroxide paste from an artificial standardized groove in the apical third of root canals.MethodologyThe root canals of 68 mandibular incisors with single oval canals were prepared using Mtwo instruments (VDW GmbH, Munich, Germany) up to size 40, .04 taper. Each tooth was split longitudinally, and in one half of the root, a standardized groove was prepared in the apical part of the specimen. The grooves were filled with Ca(OH)2, and the root halves were reassembled. The roots were randomly divided into two control groups (n = 4) and three experimental groups (n = 20) according to the Ca(OH)2 methods used: XP, PUI and SNI. The amount of remaining medicament was evaluated under X25 magnification using a 4‐grade scoring system. Kappa values were calculated for intra‐ and interobserver agreement evaluation. The differences in the Ca(OH)2 scores amongst the different groups were analysed using the Kruskal–Wallis test.ResultsNone of the tested methods could completely clean the Ca(OH)2 from the artificial standardized groove in the apical third of the root canals. XP and PUI removed significantly more Ca(OH)2 than SNI (P < 0.001), with no significant differences between them (P = 0.238).ConclusionsXP and PUI were more effective in removing Ca(OH)2 from artificial standardized grooves in the apical third of root canals than SNI.
Cost‐utility analysis of magnetoencephalography used to inform intracranial electrode placement in patients with drug resistant epilepsy: a model based analysis
Authors: Berrigan Patrick , Bardouille Tim , MacLellan Matt , Mohamed Ismail S , Murthy Manjari 
Published: June 2016

AbstractObjectivesWe estimated the cost‐effectiveness of adding magnetoencephalography to a standard assessment for epilepsy surgery consisting of neuropsychology, magnetic resonance imagining, scalp electroencephalography, video electroencephalography and intracranial electroencephalography, in the capacity of informing intracranial electroencephalography electrode placement.MethodsWe used Microsoft Excel (2007) to construct a decision model. Discounted costs and quality adjusted life years are aggregated to calculate incremental cost‐effectiveness ratios. Sensitivity analyses are conducted to assess robustness of findings.ResultsOur base case analysis yielded a result of $14 300 per quality adjusted life year gained. A total of 82.7% of probabilistic sensitivity analysis iterations resulted in incremental cost‐effectiveness ratios below $100 000 in 2014 Canadian dollars.ConclusionsOur findings demonstrate that the inclusion of Magnetoencephalography in the assessment for epilepsy surgery in the capacity of informing intracranial electroencephalography electrode placement is likely not cost saving but does represent a reasonable allocation of resources from a value for money perspective.
Empathic responsiveness and helping behaviours in young children with Williams syndrome
Authors: Plesa Skwerer D. , Tager‐Flusberg H. 
Published: June 2016

AbstractBackgroundAnecdotal and caregiver reports often highlight the sociability and empathy of children with Williams syndrome (WS), a genetically based neurodevelopmental disorder characterised by a distinctive, cognitive and social phenotype. Despite these characteristics, people with WS have many difficulties navigating the social world. In this study, we investigated whether the heightened social motivation and empathy demonstrated by children with WS lead to prosocial behaviours such as instrumental helping.MethodsWe compared 2;8 to 5;8 year olds with WS to an age‐matched and developmental quotient‐matched group of children with Down syndrome (DS) and an age‐matched group of typically developing children, in their responses to semi‐structured naturalistic situations designed to elicit empathic and helping behaviours.ResultsChildren with WS showed more empathic concern than both comparison groups towards a person in distress but did not differ from controls in their level of helping behaviour. Children in both the WS and DS groups consistently received higher ratings on empathy than on helpfulness, in contrast to the balanced profile shown by the typically developing children.DiscussionFindings suggest that the heightened emotional responsivity displayed by children with WS or DS does not readily translate into other forms of socially competent behaviour.The complex relations between empathy and prosocial behaviours in typical and atypical development are discussed.
Influence of the calf presence during milking on dairy performance, milk fatty acid composition, lipolysis and cheese composition in Salers cows during winter and grazing seasons
Authors: Cozma A. , Martin B. , Cirié C. , Verdier‐Metz I. , Agabriel J. , Ferlay A. 
Published: June 2016

SummaryThe milking of Salers cows requires the presence of the calf. The removal of the calf would simplify the milking routine, but it could also modify the milk yield and the milk and cheese composition. Therefore, the aim of this experiment was to evaluate the effect of calf presence during milking during sampling period (winter or grazing periods), on dairy performance, milk fatty acid (FA) composition, lipolysis and cheese yield and composition. Nine and 8 Salers lactating cows were milked in the presence (CP) or absence (CA) of their calves respectively. During winter, the cows were fed a hay‐based diet and then they only grazed a grassland pasture. Calf presence during milking increased milk yield and milk 16:0 concentration and decreased milk fat content and milk total odd‐ and branched‐chain FA (OBCFA) concentrations. Calf presence only increased initial lipolysis in milk collected during the winter season. Milk from CP cows compared to CA cows resulted in a lower cheese yield and ripened cheeses with lower fat content. Milk from the grazing season had lower saturated medium‐chain FA and OBCFA concentrations and higher 18:0, cis‐9‐18:1, trans‐11‐18:1 and cis‐9, trans‐11‐CLA concentrations than that from the winter season. Initial milk lipolysis was higher in the winter than in the grazing season. These variations could be due to seasonal changes in the basal diet. Furthermore, the effect of calf presence during milking on milk fat composition was lower than that on dairy performance, cheese yield and composition. Removing the calf during the milking of Salers cows seems feasible without a decrease in milked milk, and with a positive effect on cheese yield and fat content, under the condition that we are able to select cows having the capacity to be milked easily without the calf.
Effectiveness of subarachnoid drug infusion for pediatric tumor‐related pain
Authors: Higuchi Tsukasa , Shimada Kazuhiro , Cho Yoshiaki , Minami Kisei , Takeuchi Kouichi , Sakamoto Akiyuki 
Published: June 2016

AbstractAlthough the effectiveness of subarachnoid continuous drug infusion has been established in cancer pain management, its clinical use in children is rare. A 14‐year‐old girl with neurofibromatosis type I complained of right leg pain stemming from a growing tumor on her right buttock. Continuous and breakthrough right leg pain were unbearable, even at high doses of systemic opioids that caused severe constipation and deep sedation. Subsequent continuous infusion of bupivacaine and morphine through a subarachnoid catheter effectively relieved the girl's pain. The corresponding decrease in systemic opioid also improved her activities of daily living. The patient eventually died of cachexia due to the rapidly growing buttock lesion that was pathologically confirmed post‐mortem as a malignant peripheral nerve sheath tumor. Subarachnoid continuous drug infusion may be very useful in controlling severe pain with few side‐effects, even in the field of pediatric palliative care.