bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Vasospasm and Early Mortality in Severe Traumatic Brain Injury: A Model Using Serum Cytokines, Neuronal Proteins, and Clinical Data
Authors: Rindler Rima S. , Robertson Henry , De Yampert LaShondra , Khatri Vivek , Texakalidis Pavlos , Eshraghi Sheila , Grey Scott , Schobel Seth , Elster Eric A. , Boulis Nicholas , Grossberg Jonathan A. 
Published: October 2024

BACKGROUND AND OBJECTIVES:
Prediction of patient outcomes after severe traumatic brain injury (sTBI) is limited with current clinical tools. This study aimed to improve such prognostication by combining clinical data and serum inflammatory and neuronal proteins in patients with sTBI to develop predictive models for post-traumatic vasospasm (PTV) and mortality.

METHODS:
Fifty-three adult civilian patients were prospectively enrolled in the sTBI arm of the Surgical Critical Care Initiative (SC2i). Clinical, serum inflammatory, and neuronal protein data were combined using the parsimonious machine learning methods of least absolute shrinkage and selection operator (LASSO) and classification and regression trees (CART) to construct parsimonious models for predicting development of PTV and mortality.

RESULTS:
Thirty-six (67.9%) patients developed vasospasm and 10 (18.9%) died. The mean age was 39.2 years; 22.6% were women. CART identified lower IL9, lower presentation pulse rate, and higher eotaxin as predictors of vasospasm development (full data area under curve (AUC) = 0.89, mean cross-validated AUC = 0.47). LASSO identified higher Rotterdam computed tomography score and lower age as risk factors for vasospasm development (full data AUC 0.94, sensitivity 0.86, and specificity 0.94; cross-validation AUC 0.87, sensitivity 0.79, and specificity 0.93). CART identified high levels of eotaxin as most predictive of mortality (AUC 0.74, cross-validation AUC 0.57). LASSO identified higher serum IL6, lower IL12, and higher glucose as predictive of mortality (full data AUC 0.9, sensitivity 1.0, and specificity 0.72; cross-validation AUC 0.8, sensitivity 0.85, and specificity 0.79).

CONCLUSION:
Inflammatory cytokine levels after sTBI may have predictive value that exceeds conventional clinical variables for certain outcomes. IL-9, pulse rate, and eotaxin as well as Rotterdam score and age predict development of PTV. Eotaxin, IL-6, IL-12, and glucose were predictive of mortality. These results warrant validation in a prospective cohort.
The myoarchitecture of the vertebrate cardiac ventricles: evolution and classification
Authors: López-Unzu Miguel A. , Teresa Soto-Navarrete María , Sans-Coma Valentín , Fernández Borja , Carmen Durán Ana 
Published: October 2024

ABSTRACT
The ventricle of the vertebrate heart is the main segment of the cardiac outflow region. Compared with other cardiac components, it shows remarkable histomorphological variation among different animal groups. This variation is especially apparent in the myocardium, which is generally classified into three main types: trabeculated, compact and mixed. The trabeculated or ‘spongy’ myocardium is characterized by the existence of trabeculae and deep recesses or intertrabecular spaces, lined by the endocardium. The compact type is composed of condensed myocardial fibers, with almost no trabeculated layer. The mixed type consists of an outer compact layer and an inner trabeculated layer. Among vertebrates, fishes show a great diversity of myocardial types. On this basis, the ventricular myoarchitecture has been categorized into four groups of varying complexity. This classification is made according to (i) the proportion of the two types of myocardium, trabeculated versus compact, and (ii) the vascularization of the heart wall. Here, we review the morphogenetic mechanisms that give rise to the different ventricular myoarchitecture in gnathostomes (i.e. jawed vertebrates) with special emphasis on the diversity of the ventricular myocardium throughout the phylogeny of ancient actinopterygians and teleosts. Finally, we propose that the classification of the ventricular myoarchitecture should be reconsidered, given that the degrees of myocardial compactness on which the current classification system is based do not constitute discrete states, but an anatomical continuum.
Wyznanie rosyjskiego jurgeltnika.
Authors: Ciesielski Tomasz 
Published: October 2024

W artykule przedstawiona została działalność Antoniego ze Skrzynna Dunina w okresie przeislenia politycznego w Rzeczypospolitej w latach 1733-1736. Niezbyt zamożny, choć dobrze spokrewniony i skoligacony szlachcic, osiadły w województwie witebskim, wykorzystał bezkrólewia po śmierci Augusta II i wojnę o tron polski do podjęcia próby podniesienie swojego statusu materialnego i społecznego. Związał się z obozem prorosyjskim, co było w sumie naturalnym wyborem zważywszy na fakt, że jego żoną była córka feldmarszałka i wysokiego urzędnika carskiego księcia Iwana Trubeckiego Katarzyna, w Rzeczypospolitej występująca w źródłach pod imieniem Regina. W spisanym latem 1735 r. memoriale-petycji adresowanej do głównodowodzącego wojskami rosyjskim w Rzeczypospolitej księcia Ludwika von Hessen-Homburg, Antoni Dunin twierdził, że nie ograniczył się do sympatyzowania z Rosją, ale oddał też konkretne usługi ambasadorowi imperatorowej Annie w Warszawie Karolowi Gustawowi von Löwenwolde, rzekomo ratując nawet jego życie, gdyż uprzedził go o planowanym ataku wojsk polskich na siedzibę ambasadorską i Pałac Saski. Związanie się z obozem prorosyjskim sprawiło, że Dunin (jak inni jego krewni) stał się zdeklarowanym zwolennikiem księcia Fryderyka Augusta II Wettina, od 17 stycznia 1734 r. koronowanego władcy Rzeczypospolitej Augusta III.
Search for an Immobile Hider on a Binary Tree with Unreliable Locational Information
Authors: Alpern Steve , Lidbetter Thomas 
Published: October 2024

Exploiting Unreliable Information to Help Locate a Hidden Target The mathematical theory of search games was originally introduced by Shmuel Gal in 1979 to model the search for an immobile target (for instance, a landmine, improvised explosive device, or a weapons cache) on a tree network (a network without cycles). A Searcher, starting at a given point, aims to find an adversarial Hider, who is trying to maximize the time till detection. Traditionally, the Searcher has no extra information once the Hider chooses his hiding spot. In practical situations, such as detecting radioactive materials or landmines, Searchers often receive additional clues. A new study by Alpern and Lidbetter models these clues as signals that help guide the Searcher’s route. These signals, though not always accurate, suggest which paths are more promising. The study shows that with this updated model, the Hider’s best strategy shifts to hiding further from the root. This enhanced approach could improve the effectiveness of mobile sensors in real-world searches.
Inteligencia Emocional Rasgo como Factor Predictor de la Satisfacción con la Vida en Estudiantes Universitarios Peruanos y Españoles: Un Estudio Transcultural
Authors: Vilca Pareja Vilma , Cejudo Javier , Rojas Zegarra María Elena , Rodríguez-Donaire Alba 
Published: October 2024

Los objetivos de la presente investigación son: (1) determinar la relación existente entre las dimensiones de la inteligencia emocional rasgo y la satisfacción con la vida en estudiantes universitarios peruanos y españoles; (2) examinar las posibles diferencias entre la muestra peruana y española en las variables IER y satisfacción con la vida.; (3) Analizar las posibles diferencias de género en la muestra peruana y española en las variables estudiadas; (4) Examinar el efecto moderador de la cultura española y peruana en la relación entre la IER y la satisfacción con la vida. La muestra total de participantes estuvo compuesta por 1220 estudiantes universitarios, 513 fueron estudiantes peruanos, (219 hombres, 294 mujeres) cuyo rango de edad oscila entre 17 y 26 años. La media = 19.66, SD = 1.57. La muestra española fue de 707 participantes; 173 hombres, 534 mujeres, con una media = 20.45, SD = 1.88. Se utilizaron las escalas Trait Meta-Mood Scale-24 (TMMS-24) y la escala de Satisfacción con la vida (SWLS). Los resultados revelaron que la IER y la satisfacción con la vida se asocian significativamente en ambas muestras. En cuanto a la comparación entre géneros, existen diferencias significativas. Finalmente se pudo evidenciar que la cultura no modera la IER y satisfacción con la vida.
Impact of natural disasters on HIV risk behaviors, seroprevalence, and virological supression in a hyperendemic fishing village in Uganda
Authors: Nakawooya Hadijja , Ssempijja Victor , Ndyanabo Anthony , Yeh Ping Teresa , W. Chang Larry , J. Wawer Maria , Nalugoda Fred , Serwadda David , H. Gray Ronald , Kagaayi Joseph , Reynolds Steven J. , Lutalo Tom , Kigozi Godfrey , Grabowski M. Kate , Ssekubugu Robert 
Published: October 2024

Background
Understanding the impact of natural disasters on the HIV epidemic in populations with high HIV burden is critical for the effective delivery of HIV control efforts. We assessed HIV risk behaviors, seroprevalence, and viral suppression in a high HIV prevalence Lake Victoria fishing community before and after COVID-19 emergence and lockdown and a severe lake flooding event, both of which occurred in 2020.

Methods
We used data from the largest Lake Victoria fishing community in the Rakai Community Cohort Study, an open population-based HIV surveillance cohort in south-central Uganda. The data were collected both prior to (September-December 2018) and after (October-December 2021) COVID-19 emergence and a severe flooding event. Households impacted by flooding were identified via drone data and through consulting village community health workers. The entire study population was subject to extensive COVID-19-related lockdowns in the first half of 2020. Differences in HIV-related outcomes before and after COVID, and between residents of flooded and non-flooded households, were assessed using a difference-in-differences statistical modeling approach.

Findings
A total of 1,226 people participated in the pre- and post-COVID surveys, of whom 506 (41%) were affected by flooding. HIV seroprevalence in the initial period was 37% in flooded and 36.8% in non-flooded households. After the COVID-19 pandemic and lockdown, we observed a decline in HIV-associated risk behaviors: transactional sex declined from 29.4% to 24.8% (p = 0.011), and inconsistent condom use with non-marital partners declined from 41.6% to 37% (p = 0.021). ART coverage increased from 91.6% to 97.2% (p<0.001). There was 17% decline in transactional sex (aPR = 0.83, 95% CI: 0.75–0.92) and 28% decline in the overall HIV risk score (aPR = 0.83, 95% CI: 0.75–0.92) among HIV-seronegative participants. We observed no statistically significant differences in changes of HIV risk behavior, seroprevalence, or viral suppression outcomes when comparing those affected by floods to those not affected by floods, in the periods before and after COVID-19, based on difference-in-differences analyses.

Interpretation
Despite a high background burden of HIV, the COVID-19 pandemic, and severe flooding, we observed no adverse impact on HIV risk behaviors, seroprevalence, or virologic outcomes. This may be attributed to innovative HIV programming during the period and/or population resilience. Understanding exactly what HIV programs and personal or community-level strategies worked to maintain good public health outcomes despite extreme environmental and pandemic conditions may help improve HIV epidemic control during future natural disaster events.
Multilevel factors associated with delays in screening, diagnosis, and treatment for lung cancer—A mixed methods systematic review protocol
Authors: Nduaguba Sabina O. , Kelly Kimberly M. 
Published: October 2024

Background
Factors affecting time to lung cancer care may occur at multiple levels of influence. Mixed-methods reviews provide an approach for collectively synthesizing both quantitative and qualitative data. Prior reviews on timeliness of lung cancer care have included only either quantitative or qualitative data, been agnostic of the multilevel nature of influencing factors, or focused on a single factor such as gender or socioeconomic inequalities.

Objective
We aimed to update the literature on systematic reviews and identify multilevel factors associated with delays in lung cancer screening, diagnosis, and treatment.

Design
The proposed systematic review will be conducted in accordance with the Joanna Briggs Institute (JBI) Manual for Evidence Synthesis specific for mixed methods systematic reviews. Reporting will be consistent with PRISMA guidelines.

Methods
Medline (PubMed), CINAHL, and SCOPUS will be searched using validated search terms for lung cancer and factors, health disparities and time/delay. Eligible studies will include original articles with quantitative, qualitative, or mixed-methods designs that investigate health disparities in, risk factors for, or barriers to timely screening, confirmatory diagnosis, or treatment among patients with lung cancer or those at risk for lung cancer. Title, abstract, and full-text screening, study quality assessment, and data extraction will be conducted by two reviewers. A convergent integrated approach with thematic synthesis will be applied to synthesize the extracted and generated analytical themes.

Discussion
Findings from this review will inform the design of an intervention to address delays in lung cancer screening for high-risk persons, diagnosis of suspected lung cancer, and treatment of confirmed cases.
Analysis of low-density lipoprotein receptor gene mutations in a family with familial hypercholesterolemia
Authors: Hu Ya-nan , Wu Min , Yu Hong-ping , Wu Qiu-yan , Chen Ying , Zhang Jian-Hui , Ruan Dan-dan , Zhang Yan-ping , Zou Jing , Zhang Li , Lin Xin-fu , Fang Zhu-ting , Liao Li-Sheng , Lin Fan , Li Hong , Luo Jie-Wei 
Published: October 2024

Background
Familial hypercholesterolemia (FH) is a common monogenic autosomal dominant disorder, primarily mainly caused by pathogenic mutations in the low-density lipoprotein receptor (LDLR) gene. Through phenotypic-genetic linkage analysis, two LDLR pathogenic mutations were identified in FH families: c.G1027A (p.Gly343Ser) and c.G1879A (p.Ala627Thr).

Materials and methods
Whole exome sequencing was conducted on the proband with familial hypercholesterolemia to identify the target gene and screen for potential pathogenic mutations. The suspicious responsible mutation sites in 14 family members were analyzed using Sanger sequencing to assess genotype-phenotype correlations. Mutant and wild type plasmids were constructed and transfected into HEK293T cells to evaluate LDLR mRNA and protein expression. In parallel, bioinformatics tools were employed to predict structural and functional changes in the mutant LDLR.

Results
Immunofluorescence analysis revealed no significant difference in the intracellular localization of the p.Gly343Ser mutation, whereas protein expression of the p.Ala627Thr mutation was decreased and predominantly localized in the cytoplasm. Western blotting has showed that protein expression levels of the mutant variants were markedly declined in both cell lysates and supernatants. Enzyme linked immunosorbent assay has demonstrated that LDLR protein levels in the supernatant of cell culture medium was not significant different from those of the wild-type group. However, LDLR protein levels in the cell lysate of both the Gly343Ser and Ala627Thr variants groups were significantly lower than those in the wild-type group. Bioinformatic predictions further suggested that these mutations may affect post-translational modifications of the protein, providing additional insight into the mechanisms underlying the observed reduction in protein expression.

Conclusions
In this study, we identified two heterozygous pathogenic variants in the LDLR gene, c.G1027A (p.Gly343Ser) and c.G1879A (p.Ala627Thr), in a family with familial hypercholesterolemia. We also conducted preliminary investigations into the mechanisms by which these mutations contribute to disease pathology.
Comparative study of machine learning approaches integrated with genetic algorithm for IVF success prediction
Authors: Dehghan Shirin , Rabiei Reza , Choobineh Hamid , Maghooli Keivan , Nazari Mozhdeh , Vahidi-Asl Mojtaba 
Published: October 2024

Introduction
IVF is a widely-used assisted reproductive technology with a consistent success rate of around 30%, and improving this rate is crucial due to emotional, financial, and health-related implications for infertile couples. This study aimed to develop a model for predicting IVF outcome by comparing five machine-learning techniques.

Method
The research approached five prominent machine learning algorithms, including Random Forest, Artificial Neural Network (ANN), Support Vector Machine (SVM), Recursive Partitioning and Regression Trees (RPART), and AdaBoost, in the context of IVF success prediction. The study also incorporated GA as a feature selection method to enhance the predictive models’ robustness.

Results
Findings demonstrate that AdaBoost, particularly when combined with GA feature selection, achieved the highest accuracy rate of 89.8%. Using GA, Random Forest also demonstrated strong performance, achieving an accuracy rate of 87.4%. Genetic Algorithm significantly improved the performance of all classifiers, emphasizing the importance of feature selection. Ten crucial features, including female age, AMH, endometrial thickness, sperm count, and various indicators of oocyte and embryo quality, were identified as key determinants of IVF success.

Conclusion
These findings underscore the potential of machine learning and feature selection techniques to assist IVF clinicians in providing more accurate predictions, enabling tailored treatment plans for each patient. Future research and validation can further enhance the practicality and reliability of these predictive models in clinical IVF practice.
THE PHILOSOPHY FOUNDATIONS OF MARKETING THEORY AND RESEARCH
Authors: Negara Danes Jaya 
Published: October 2024

In marketing, there had been a simmering debate about its scientific status during the 1950s and 1960s but the Fall 1983 issue of the Journal of Marketing marked the start of this particular episode. This article provides the philosophy foundations of marketing thought at two centers of early development. In particular is to evaluate scientific realism view and relativistic/contructionist view. The author explores the nature of realism and relativism as it is currently being discussed in the philosophy of science. Scientific realism argues that truth is appropriate goal for marketing theory and research and that science can come to know the real word, though not with certainty. They argue that there is no grand theory of science. Relativists have long argued that there is no single method or approach to science. After addressing a fundamental premise of the entire debate, the author concludes that philosophically oriented marketing theorists need to further demonstrate the value of their work tor practicing marketing scientists.
WORD OF MOUTH (WOM) DALAM INDUSTRI JASA : KAITANNYA DENGAN SIKAP DAN KEMUNGKINAN MEMBELI
Authors: Harsasi Meirani 
Published: October 2024

In buying a service, consumers often find it is difficult to choose a suitable service provider that will serve them as they are expected. This is happened because the nature of a service is intangibility so consumers can assess the quality of a service after they consume it. One easy way for consumers to obtain information about a service is by asking someone who has consumed the same service before. This is called word of mouth = WOM. Some researches indicate that WOM can influence the possibility of a consumer to choose and buy a service. Furthermore, an unsatisfied consumer will tell more people about a bad service than a satisfied consumer who will tells less people about a good service. This means that someone who accepts the information especially about negative WOM will possibly not do the same service purchasing. WOM can influence the possibility of someone's intention to buy a service according to a research conducted by Charlett et al in 1995. Februadi and Kusdibyo conducted the same research in 2003 and the result showed sameness to Charletrs. Particularly, the research also indicated that the negative WOM have a stronger influence compared to positive WOM. Therefore, service providers have to improve their service quality in many ways in order to deliver the suitable value for consumers. A service marketing strategy is needed here which difference than a product marketing strategy. In lessening the negative impact of WOM, a service provider better to conduct a service marketing covering internal marketing, external marketing, and interactive marketing.
Nursing students’ experience of a transformative approach to teaching cross cultural clinical decision making
Authors: Orchard Carole A. , Evans Marilyn K. , Tuyisenge Germaine , Ugirase Sibylle , Kasine Yvonne , Umubyeyi Benoite , Uwajeneza Pauline 
Published: October 2024

Abstract

Objectives
This study reveals the learning gained by Canadian and Rwandan nursing students from a course to enhance cross cultural clinical decision-making skills using a collaborative approach across two countries.

Methods
A qualitative descriptive study was conducted using thematic analysis. The study included analysis of end of course reflections of 94 students.

Results
Students became more open-minded, curious, strengthening teamwork, increasing their critical thinking, and identifying cross-cultural similarities in practice. They challenged their previous beliefs about others.

Conclusions
Students achieved a transformation of previous knowledge and decision-making skills. Results indicate the value of underpinning courses with theories and being open in allowing students to develop their own means to achieve expected learning outcomes.

Implications for an international audience
Creating learning environments designed to stimulate open mindedness and exploration of cultures among students can be achieved through online learning. Providing opportunities for students to learn across other countries about their nursing practices and health systems are critical to understanding how future patients who are immigrants and refugees from other countries differing perspectives to their health care needs.