bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers
Authors: Zhang Qing‐Wei , Brusoe Andrew T. , Mascitti Vincent , Hesp Kevin D. , Blakemore David C. , Kohrt Jeffrey T. , Hartwig John F. 
Published: July 2016

AbstractThe synthesis of mono‐, di‐, and trifluoromethyl aryl ethers by fluorodecarboxylation of the corresponding carboxylic acids is reported. AgF2 induces decarboxylation of aryloxydifluoroacetic acids, and AgF, either generated in situ or added separately, serves as a source of fluorine to generate the fluorodecarboxylation products. The addition of 2,6‐difluoropyridine increased the reactivity of AgF2, thereby increasing the range of functional groups and electronic properties of the aryl groups that are tolerated. The reaction conditions used for the formation of trifluoromethyl aryl ethers also served to form difluoromethyl and monofluoromethyl aryl ethers.
Versatile Room‐Temperature‐Phosphorescent Materials Prepared from N‐Substituted Naphthalimides: Emission Enhancement and Chemical Conjugation
Authors: Chen Xiaofeng , Xu Cheng , Wang Tao , Zhou Cao , Du Jiajun , Wang Zhongping , Xu Hangxun , Xie Tongqing , Bi Guoqiang , Jiang Jun , Zhang Xuepeng , Demas James N. , Trindle Carl O. , Luo Yi , Zhang Guoqing 
Published: July 2016

AbstractPurely organic materials with room‐temperature phosphorescence (RTP) are currently under intense investigation because of their potential applications in sensing, imaging, and displaying. Inspired by certain organometallic systems, where ligand‐localized phosphorescence (3π‐π*) is mediated by ligand‐to‐metal or metal‐to‐ligand charge transfer (CT) states, we now show that donor‐to‐acceptor CT states from the same organic molecule can also mediate π‐localized RTP. In the model system of N‐substituted naphthalimides (NNIs), the relatively large energy gap between the NNI‐localized 1π‐π* and 3π‐π* states of the aromatic ring can be bridged by intramolecular CT states when the NNI is chemically modified with an electron donor. These NNI‐based RTP materials can be easily conjugated to both synthetic and natural macromolecules, which can be used for RTP microscopy.
Tartrate‐Resistant Acid Phosphatase Deficiency in the Predisposition to Systemic Lupus Erythematosus
Authors: An Jie , Briggs Tracy A. , Dumax‐Vorzet Audrey , Alarcón‐Riquelme Marta E. , Belot Alexandre , Beresford Michael , Bruce Ian N. , Carvalho Claudia , Chaperot Laurence , Frostegård Johan , Plumas Joel , Rice Gillian I. , Vyse Timothy J. , Wiedeman Alice , Crow Yanick J. , Elkon Keith B. 
Published: July 2016

ObjectiveMutations in the ACP5 gene, which encodes tartrate‐resistant acid phosphatase (TRAP), cause the immuno‐osseous disorder spondyloenchondrodysplasia, which includes as disease features systemic lupus erythematosus (SLE) and a type I interferon (IFN) signature. Our aims were to identify TRAP substrates, determine the consequences of TRAP deficiency in immune cells, and assess whether ACP5 mutations are enriched in sporadic cases of SLE.MethodsInteraction between TRAP and its binding partners was tested by a yeast 2‐hybrid screening, confocal microscopy, and immunoprecipitation/Western blotting. TRAP knockdown was performed using small interfering RNA. Phosphorylation of osteopontin (OPN) was analyzed by mass spectrometry. Nucleotide sequence analysis of ACP5 was performed by Sanger sequencing or next‐generation sequencing.ResultsTRAP and OPN colocalized and interacted in human macrophages and plasmacytoid dendritic cells (PDCs). TRAP dephosphorylated 3 serine residues on specific OPN peptides. TRAP knockdown resulted in increased OPN phosphorylation and increased nuclear translocation of IRF7 and P65, with resultant heightened expression of IFN‐stimulated genes and IL6 and TNF following Toll‐like receptor 9 stimulation. An excess of heterozygous ACP5 missense variants was observed in SLE compared to controls (P = 0.04), and transfection experiments revealed a significant reduction in TRAP activity in a number of variants.ConclusionOur findings indicate that TRAP and OPN colocalize and that OPN is a substrate for TRAP in human immune cells. TRAP deficiency in PDCs leads to increased IFNα production, providing at least a partial explanation for how ACP5 mutations cause lupus in the context of spondyloenchondrodysplasia. Detection of ACP5 missense variants in a lupus cohort suggests that impaired TRAP functioning may increase susceptibility to sporadic lupus.
Efficient Iterative Synthesis of O‐Acetylated Tri‐ to Pentadecasaccharides Related to the Lipopolysaccharide of Shigella flexneri Type 3 a through Di‐ and Trisaccharide Glycosyl Donors
Authors: Hu Zhaoyu , Bongat White Aileen F. , Mulard Laurence A. 
Published: July 2016

AbstractProtection against bacterial infections, including shigellosis, can be achieved by antibodies against the bacterial surface polysaccharide. In line with our efforts to develop vaccine candidates for shigellosis, we report herein the synthesis of penta‐, deca‐, and pentadecasaccharides as well as tri‐, octa‐, and tridecasaccharides as the endchain and intrachain fragments, respectively, of the surface polysaccharide of Shigella flexneri 3 a, a prevalent serotype. The syntheses relied on the efficiency of the trichloroacetimidate glycosylation chemistry, whereby iteration with di‐ and trisaccharide building blocks provided fragments made of up to three mono‐O‐acetylated polysaccharide repeating units. Pd(OH)2‐mediated hydrogenation/hydrogenolysis enabled the concomitant removal or conversion of up to 31 protecting groups of 4 different origins to provide the targets as propyl glycosides. Oligosaccharides comprising the octasaccharide segment were shown to display high conformational similarities in solution.
In utero exposure to venlafaxine, a serotonin–norepinephrine reuptake inhibitor, increases cardiac anomalies and alters placental and heart serotonin signaling in the rat
Authors: Laurent Laetitia , Huang Chunwei , Ernest Sheila R. , Berard Anick , Vaillancourt Cathy , Hales Barbara F. 
Published: July 2016

BackgroundHuman studies are inconsistent with respect to an association between treatment with selective serotonin and serotonin–norepinephrine reuptake inhibitors (SSRI/SNRIs) and an increase in the incidence of congenital heart defects. Here we tested the hypothesis that in utero exposure to venlafaxine, a highly prescribed SNRI, increases the incidence of fetal heart defects and alters placental and fetal heart serotonin signaling in the rat.MethodsTimed‐pregnant Sprague Dawley rats were gavaged daily with venlafaxine hydrochloride (0, 3, 10, 30, or 100 mg/kg/day) from gestation day 8 to 20. On gestation day 21, fetuses were examined for external and internal malformations; placentas and fetal hearts were collected for the analysis of gene expression.ResultsVenlafaxine had no effect on the number of live fetuses, fetal body weights, or external morphology in the absence of maternal toxicity. However, venlafaxine significantly increased the placental index (fetal body/placental weight ratio) and the incidence of fetal cardiac anomalies. Venlafaxine exposure decreased placental expression of the serotonin transporter (SERT/Slc6a4) at the transcript and protein levels. In contrast, venlafaxine increased SERT expression in the hearts of female, but not male, fetuses. Expression of the serotonin 2B receptor (5‐HT2B/Htr2b) and of fibroblast growth factor 8 was induced in fetal hearts.ConclusionIn utero venlafaxine exposure altered the placental index and induced fetal cardiac anomalies in rats. We propose that the increased incidence of cardiac anomalies is mediated through alterations in serotonin signaling in the placenta and fetal heart. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc. Birth Defects Research (Part A) 106:1044–1055, 2016. © 2016 Wiley Periodicals, Inc.
Dy3+‐, Sm3+‐, Ce3+‐ and Tb3+‐activated optical properties of microcrystalline BaMgP2O7 phosphors
Authors: Wani J. A. , Dhoble N. S. , Kokode N. S. , Singh Vijay , Dhoble S. J. 
Published: July 2016

AbstractPhotoluminescence (PL) and thermoluminescence (TL) properties of rare earth (RE) ion (RE = Dy3+, Sm3+, Ce3+, Tb3+) activated microcrystalline BaMgP2O7 phosphors are presented in this work. Non‐doped and doped samples of BaMgP2O7 were prepared using a solid state diffusion method and characterized by X‐ray diffraction (XRD), scanning electron microscopy (SEM), PL and TL. The XRD measurement confirmed the phase purity of the BaMgP2O7 host matrix. The average particle size was found through SEM measurement to be around 2 μm. All activators using the PL technique displayed characteristic excitation and emission spectra that corresponded to their typical f → f and f → d transitions respectively. Thermoluminescence measurements showed that BaMgP2O7:RE (RE = Dy3+, Sm3+, Tb3+, Ce3+) and co‐doped BaMgP2O7:Ce3+,Tb3+ phosphors have also TL behaviour.
Activist Theatre: The Effects of Community Performance on System Justification and Willingness to Engage in Activism
Authors: Vogel Autumn M. , Jackson Lydia Eckstein 
Published: July 2016

AbstractSystem justification is a motivation to legitimize the status quo that disables individuals from changing oppressive social systems. Community performance has long been used as a tool to illuminate and challenge such systems of power. The goal of the present study was to provide an empirical test of the effectiveness of community performance in the context of gender‐based oppression. Specifically, the present study tested whether a community performance could decrease audience members' system justification and increase intentions to engage in collective and virtual action to correct these oppressive systems. The performance consisted of 18 community‐created pieces performed by 11 actresses before an audience of 165 members of the college and local communities across three days. A total of 153 audience members participated in the study. Results indicated that a 50‐min performance reduced system justification while increasing willingness to take collective and virtual‐based action. Limitations and implications are discussed. Copyright © 2016 John Wiley & Sons, Ltd.
Understanding perspectives of signalling mechanisms regulating PEBP1 function
Authors: Rajkumar Karthik , Nichita Aare , Anoor Pawan Kumar , Raju Swathi , Singh Surya Satyanarayana , Burgula Sandeepta 
Published: July 2016

Phosphatidylethanolamine‐binding protein 1 (PEBP1), also known as Raf kinase inhibitor protein, belongs to PEBP family of proteins. It is known to interact with many proteins that are mainly involved in pathways that monitor cell proliferation and differentiation. PEBP1 in many cells interacts with several pathways, namely MAPK, GRK2, NF‐кB, etc. that keeps the cell proliferation and differentiation in check. This protein is expressed by many cells in humans, including neurons where it is predominantly involved in production of choline acetyltransferase. Deregulated PEBP1 is known to cause cancer, diabetic nephropathy and neurodegenerative diseases like Alzheimer's and dementia. Recent research led to the discovery of many drugs that mainly target the interaction of PEBP1 with its partners. These compounds are known to bind PEBP1 in its conserved domain which abrogate its association with interacting partners in several different pathways. We outline here the latest developments in understanding of PEBP1 function in maintaining cell integrity. Copyright © 2016 John Wiley & Sons, Ltd.Significance of the StudyPhosphatidylethanolamine‐binding protein is crucial in regulation of MAPK and PKC pathways. Its diverse roles, including regulating these pathways keep cell differentiation and proliferation in check. This review outlines some latest findings which greatly add to our current knowledge of phosphatidylethanolamine‐binding protein.
Trifluoroselenomethionine: A New Unnatural Amino Acid
Authors: Block Eric , Booker Squire J. , Flores‐Penalba Sonia , George Graham N. , Gundala Sivaji , Landgraf Bradley J. , Liu Jun , Lodge Stephene N. , Pushie M. Jake , Rozovsky Sharon , Vattekkatte Abith , Yaghi Rama , Zeng Huawei 
Published: July 2016

AbstractTrifluoroselenomethionine (TFSeM), a new unnatural amino acid, was synthesized in seven steps from N‐(tert‐butoxycarbonyl)‐l‐aspartic acid tert‐butyl ester. TFSeM shows enhanced methioninase‐induced cytotoxicity, relative to selenomethionine (SeM), toward HCT‐116 cells derived from human colon cancer. Mechanistic explanations for this enhanced activity are computationally and experimentally examined. Comparison of TFSeM and SeM by selenium EXAFS and DFT calculations showed them to be spectroscopically and structurally very similar. Nonetheless, when two different variants of the protein GB1 were expressed in an Escherichia coli methionine auxotroph cell line in the presence of TFSeM and methionine (Met) in a 9:1 molar ratio, it was found that, surprisingly, 85 % of the proteins contained SeM residues, even though no SeM had been added, thus implying loss of the trifluoromethyl group from TFSeM. The transformation of TFSeM into SeM is enzymatically catalyzed by E. coli extracts, but TFSeM is not a substrate of E. coli methionine adenosyltransferase.
Laboratory‐Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme‐Catalyzed Epoxide Hydrolysis
Authors: Janfalk Carlsson Åsa , Bauer Paul , Dobritzsch Doreen , Nilsson Mikael , Kamerlin S. C. Lynn , Widersten Mikael 
Published: July 2016

AbstractEngineered enzyme variants of potato epoxide hydrolase (StEH1) display varying degrees of enrichment of (2R)‐3‐phenylpropane‐1,2‐diol from racemic benzyloxirane. Curiously, the observed increase in the enantiomeric excess of the (R)‐diol is not only a consequence of changes in enantioselectivity for the preferred epoxide enantiomer, but also to changes in the regioselectivity of the epoxide ring opening of (S)‐benzyloxirane. In order to probe the structural origin of these differences in substrate selectivity and catalytic regiopreference, we solved the crystal structures for the evolved StEH1 variants. We used these structures as a starting point for molecular docking studies of the epoxide enantiomers into the respective active sites. Interestingly, despite the simplicity of our docking analysis, the apparent preferred binding modes appear to rationalize the experimentally determined regioselectivities. The analysis also identifies an active site residue (F33) as a potentially important interaction partner, a role that could explain the high conservation of this residue during evolution. Overall, our experimental, structural, and computational studies provide snapshots into the evolution of enantioconvergence in StEH1‐catalyzed epoxide hydrolysis.
Electro‐assisted Deposition of Binary Self‐Assembled 1,2‐Dithiolane Monolayers on Gold with Predictable Composition
Authors: Capitao Dany , Sahli Rihab , Raouafi Noureddine , Limoges Benoit , Fave Claire , Schöllhorn Bernd 
Published: July 2016

AbstractA reproducible electro‐assisted method was proposed for the fast and well‐controlled formation of mixed binary 1,2‐dithiolane‐based self‐assembled monolayers (SAMs) on a gold electrode from micromolar adsorbate solution concentrations. This was made possible by the combined use of 1,2‐dithiolane derivatives having comparable surface binding affinities and the application of a moderate cathodic potential to the electrode until an equilibrium binary SAM coverage was reached. Dithiolane derivatives containing distinct redox‐active ferrocenyl groups were synthesized and used for simultaneous and quantitative electrochemical monitoring of the formation of the binary SAMs. The corresponding separate electrochemical responses of each component in the mixed layer allowed for the determination of the adsorbate ratio, which afforded the overall and the individual chemisorption kinetics. Regardless of the different adsorption kinetics, the resulting adsorbate ratios at equilibrium in the SAM were found to be the same as those in solution. Upon reporting the equilibrium surface concentration of the adsorbate as a function of its mole fraction in solution, a clear‐cut linear relationship was obtained, which makes this method particularly useful for controlling and predicting the chemical composition of functional binary SAMs on gold surfaces.
Biocatalysis and Biomass Conversion in Alternative Reaction Media
Authors: Sheldon Roger A. 
Published: July 2016

AbstractIn this Minireview, the state of the art in the use of ionic liquids (ILs) and deep eutectic solvents (DESs) as alternative reaction media for biocatalytic processes and biomass conversion is presented. Initial, proof‐of‐concept studies, more than a decade ago, involved first‐generation ILs based on dialkylimidazolium cations and non‐coordinating anions, such as tetrafluoroborate and hexafluorophosphate. More recently, emphasis has switched to more environmentally acceptable second‐generation ILs comprising cations, which are designed to be compatible with enzymes and, in many cases are derived from readily available, renewable resources, such as cholinium salts. Protic ionic liquids (PILs), prepared simply by mixing inexpensive amines and acids, are particularly attractive from both an environmental and economic viewpoint. DESs, prepared by mixing inexpensive salts with, preferably renewable, hydrogen‐bond donors such as glycerol and amino acids, have also proved suitable reaction media for biocatalytic conversions. A broad range of enzymes can be used in ILs, PILs and DESs, for example lipases in biodiesel production. These neoteric solvents are of particular interest, however, as reaction media for biocatalytic conversions of substrates that have limited solubility in common organic solvents, such as carbohydrates, nucleosides, steroids and polysaccharides. This has culminated in the recent focus of attention on their use as (co)solvents in the pretreatment and saccharification of lignocellulose as the initial steps in the conversion of second‐generation renewable biomass into biofuels and chemicals. They can similarly be used as reaction media in subsequent conversions of hexoses and pentoses into platform chemicals.
ChemInform Abstract: 3D Transition Metal Ordering and Rietveld Stacking Fault Quantification in the New Oxychalcogenides La2O2Cu2—4xCd2xSe2 .
Authors: Ainsworth Chris M. , Lewis James W. , Wang Chun‐Hai , Coelho Alan A. , Johnston Hannah E. , Brand Helen E. A. , Evans John S. O. 
Published: July 2016

AbstractPolycrystalline samples of La2O2Cu2‐4xCd2xSe2 (x = 0—0.5) are prepared by solid state reaction of La2O3 and the elements in the presence of Al powder as O2 getter (Al2O3 crucible in evacuated silica tubes, 1100 °C, 12 h).
ChemInform Abstract: Baromagnetic Effect in Antiperovskite Mn3Ga0.95N0.94 by Neutron Powder Diffraction Analysis.
Authors: Wang Cong , et al.  
Published: July 2016

AbstractPolycrystalline samples of the Mn3GaN antiperovskite are prepared by sintering stoichiometric amounts of Mn2N and Ga (evacuated quartz tubes, 800 °C, several days).
ChemInform Abstract: Effect of the [Ba2BO3F]∞ Layer on the Band Gap: Synthesis, Characterization, and Theoretical Studies of BaZn2B2O6·nBa2 BO3F (n = 0, 1, 2).
Authors: Wu Hongping , Su Xin , Han Shujuan , Yang Zhihua , Pan Shilie 
Published: July 2016

AbstractSingle crystals of Ba3Zn2B3O9F (I) and Ba5Zn2B4O12F2 (II) are synthesized from mixtures of BaF2, PbO, ZnO, and H3BO3 (850—900 °C, 10 h, 30% and 80% yield for (I) and (II), respectively).
ChemInform Abstract: Synergistic Kinetic Resolution and Asymmetric Propargyl Claisen Rearrangement for the Synthesis of Chiral Allenes.
Authors: Liu Yangbin , Liu Xiaohua , Hu Haipeng , Guo Jing , Xia Yong , Lin Lili , Feng Xiaoming 
Published: July 2016

AbstractThe kinetic resolution of racemic propargyl vinyl ethers (I) through an enantioselective Claisen rearrangement affords chiral allenes (II) and enantiopure ethers (S)‐(I).
ChemInform Abstract: A Novel Coupling Reaction of α‐Halo Ketones Promoted by SmI3/CuI.
Authors: Liu Yongjun , Zhao Hengmin , Tian Guang , Du Feng , Qi Yan , Wen Yonghong 
Published: July 2016

AbstractIn the presented approach DMF plays a dual role both as a hydroxyl source and as a solvent.
ChemInform Abstract: Divergent Syntheses of Isoquinolines and Indolo[1,2‐a]quinazolines by Copper‐Catalyzed Cascade Annulation from 2‐Haloaryloxime Acetates with Active Methylene Compounds and Indoles.
Authors: Jiang Huanfeng , Yang Jidan , Tang Xiaodong , Wu Wanqing 
Published: July 2016

AbstractA convenient and reliable method for the direct construction of isoquinolines via copper‐catalyzed cascade condensation between haloaryloxime acetates and diverse β‐diketo compounds is described.
ChemInform Abstract: Direct Acylation of C(sp3)—H Bonds Enabled by Nickel and Photoredox Catalysis.
Authors: Joe Candice L. , Doyle Abigail G. 
Published: July 2016

AbstractThe acylation of N‐arylpyrrolidines (I) with anhydrides (II) or thioesters (IV) gives rise to N‐aryl‐2‐ketopyrrolidines (III) and (V), resp., in moderate to good yields.
ChemInform Abstract: Hypervalent Iodine as a Terminal Oxidant in Wacker‐Type Oxidation of Terminal Olefins to Methyl Ketones.
Authors: Chaudhari Dipali A. , Fernandes Rodney A. 
Published: July 2016

AbstractA Markovnikov‐selective oxidation of terminal olefins by a combination of palladium(II) acetate and Dess—Martin periodinane is described.
ChemInform Abstract: Enantioselective Vicinal Diacetoxylation of Alkenes under Chiral Iodine(III) Catalysis.
Authors: Woeste Thorsten H. , Muniz Kilian 
Published: July 2016

AbstractIodophenylene‐linked lactate esters are applied as chiral organocatalysts in the asymmetric vicinal diacetoxylation of styrene and cinnamyl alcohol substrates affording the acetoxy derivatives in modest to good yields and good dia‐ as well as enantioselectivities.
ChemInform Abstract: Copper(II)‐Catalyzed C5 and C7 Halogenation of Quinolines Using Sodium Halides under Mild Conditions.
Authors: Xu Jun , Zhu Xiaolei , Zhou Guobin , Ying Beibei , Ye Pingping , Su Lingying , Shen Chao , Zhang Pengfei 
Published: July 2016

AbstractSelective mono‐ and dihalogenation of quinolinamines is achieved depending on the quantities of the used sodium halides.
ChemInform Abstract: Visible‐Light Photocatalytic α‐Amino C(sp3)—H Activation Through Radical Translocation: A Novel and Metal‐Free Approach to α‐Alkoxybenzamides.
Authors: Huang Feng‐Qing , Dong Xin , Qi Lian‐Wen , Zhang Bo 
Published: July 2016

Abstracto‐Aminobenzamides are converted into diazonium salt intermediates, which can be reduced to generate aryl radicals.
ChemInform Abstract: A Three‐Component Reagent System for Rapid and Mild Removal of O‐, N‐ and S‐Trityl Protecting Groups.
Authors: Kicsak Mate , Bege Miklos , Bereczki Ilona , Csavas Magdolna , Herczeg Mihaly , Kupihar Zoltan , Kovacs Lajos , Borbas Aniko , Herczegh Pal 
Published: July 2016

AbstractUsing a triethylsilane/boron trifluoride etherate/hexafluoroisopropanol system, trityl‐type protecting groups are easily and selectively removed from O‐, N‐ and/or S‐functions of a number of nucleoside and sugar substrates.
ChemInform Abstract: Oxidative Aminoaziridination of 2‐Vinylfuran Derivatives as an Approach to Hexa‐2,5‐diene‐1,4‐dione Monohydrazones.
Authors: Sorokina Mariia V. , Pankova Alena S. , Kuznetsov Mikhail A. 
Published: July 2016

AbstractOxidative addition of N‐aminophthalimides to 2‐vinylfuran derivatives gives the title compounds instead of 2‐furylaziridines.
ChemInform Abstract: Ferromagnetic α‐Fe2O3NPs: A Potential Catalyst in Sonogashira—Hagihara Cross Coupling and Hetero‐Diels—Alder Reactions.
Authors: Kataria Meenal , Pramanik Subhamay , Kaur Navleen , Kumar Manoj , Bhalla Vandana 
Published: July 2016

AbstractFerromagnetic α‐Fe2O3 nanoparticles are shown to be an efficient catalyst for Sonogashira—Hagihara cross coupling and hetero Diels—Alder reactions.