bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrence of Solid Pseudopapillary Neoplasms of the Pancreas: Results of a Nationwide Study of Risk Factors and Treatment Modalities
Authors: Irtan Sabine , Galmiche‐Rolland Louise , Elie Caroline , Orbach Daniel , Sauvanet Alain , Elias Dominique , Guérin Florent , Coze Carole , Faure‐Conter Cécile , Becmeur François , Demarche Martine , Galifer René Benoît , Galloy Marie Agnès , Podevin Guillaume , Aubert Didier , Piolat Christian , De Lagausie Pascal , Sarnacki Sabine 
Published: May 2016

BackgroundSolid pseudopapillary neoplasms of the pancreas (SPPN) can relapse very late, but little is known about risk factors for recurrence and optimal treatment. We aimed to identify risk factors for recurrence and to analyze treatment modalities in all French pediatric cases of SPPN over the past 20 years.Material and methodsData were collected from pediatric oncologists and surgeons, and also from adult pancreatic surgeons in order to identify late recurrences.ResultsFifty‐one patients (41 girls) were identified. Median age at diagnosis was 13.1 years [8.7–17.9]. Abdominal pain was the commonest presenting symptom (32/49, 65%). The tumor was located in the pancreatic head in 24 patients (47%). Preoperative biopsy or cytology was performed in 14 cases (28%). All patients were operated with a median of 23 days [0–163] after diagnosis. The rate of postoperative morbidity was 29%. With a median follow‐up of 65 months [0.3–221], the overall and event‐free survival was 100% and 71%, respectively. Seven patients (13.7%) relapsed with a median of 43 months [33–94] after initial surgery. Six were treated surgically, either alone (n = 3) or with perioperative chemotherapy (n = 2) or hyperthermic intraperitoneal chemotherapy (n = 1). One patient in whom further treatment was not feasible was still alive at last news. Risk factors for recurrence were positive surgical margins (P = 0.03) and age less than 13.5 years at diagnosis (P = 0.03).ConclusionsSPPN recurrence in this pediatric series was a rare and late event that did not undermine overall survival. Complete surgical removal of recurrent tumors appears to be the best option.
The Feasibility of Physical Activity Interventions During the Intense Treatment Phase for Children and Adolescents with Cancer: A Systematic Review
Authors: Grimshaw Sarah L. , Taylor Nicholas F. , Shields Nora 
Published: May 2016

BackgroundPhysical activity may have benefits for children undergoing intense treatment for cancer, but such programmes are challenging to implement. This systematic review aimed to investigate the feasibly of physical activity interventions during intense cancer treatment for children and adolescents.ProcedureA systematic search of seven electronic databases (Cumulative Index to Nursing and Allied Health Literature, Medical Literature Analysis and Retrieval System Online, Public/Publisher MEDLINE, Psychological Information Database, Sportsdiscuss, Excerpta Medica Database, Allied and Complementary Medicine Database) from 2005 to August 2015 was completed. The risk of bias was assessed using the Downs and Black Checklist and The Critical Review Form–Qualitative Studies. Results were summarised descriptively across eight domains of feasibility: acceptability, demand, implementation, adaptation, practicality, integration, expansion and limited efficiency testing (including effectiveness).ResultsEleven quantitative studies and one qualitative study were identified for inclusion. Physical activity interventions were typically supervised, individualised programmes that prescribed a variety of activity types for hospital inpatients. There was evidence that physical activity interventions during the intense phase of cancer treatment were acceptable to parents and children, safe and successfully implemented. A trend of positive effects across all aspects of functioning was noted. Data were unavailable documenting feasibility for the domains of integration, adaptation and expansion.ConclusionThere is preliminary evidence that physical activity interventions are feasible, in that they are acceptable, safe and potentially beneficial for children with cancer but more work needs to be done to understand the most effective ways to implement these types of programmes.
Evidence generation from healthcare databases: recommendations for managing change
Authors: Bourke Alison , Bate Andrew , Sauer Brian C. , Brown Jeffrey S. , Hall Gillian C. 
Published: May 2016

AbstractThere is an increasing reliance on databases of healthcare records for pharmacoepidemiology and other medical research, and such resources are often accessed over a long period of time so it is vital to consider the impact of changes in data, access methodology and the environment. The authors discuss change in communication and management, and provide a checklist of issues to consider for both database providers and users. The scope of the paper is database research, and changes are considered in relation to the three main components of database research: the data content itself, how it is accessed, and the support and tools needed to use the database. Copyright © 2016 John Wiley & Sons, Ltd.
Synthesis, characterization and self‐assembly of well‐defined linear heptablock quaterpolymers
Authors: Ntaras Christos , Polymeropoulos George , Zapsas George , Ntetsikas Konstantinos , Liontos George , Karanastasis Apostolos , Moschovas Dimitrios , Rangou Sofia , Stewart‐Sloan Charlotte , Hadjichristidis Nikos , Thomas Edwin L. , Avgeropoulos Apostolos 
Published: May 2016

ABSTRACTTwo well‐defined heptablock quaterpolymers of the ABCDCBA type [Α: polystyrene (PS), B: poly(butadiene) with ∼90% 1,4‐microstructure (PB1,4), C: poly(isoprene) with ∼55% 3,4‐microstructure (PI3,4) and D: poly(dimethylsiloxane) (PDMS)] were synthesized by combining anionic polymerization high vacuum techniques and hydrosilylation/chlorosilane chemistry. All intermediates and final products were characterized by size exclusion chromatography, membrane osmometry, and proton nuclear magnetic resonance spectroscopy. Fourier transform infrared spectroscopy was used to further verify the chemical modification reaction of the difunctional PDMS. The self‐assembly in bulk of these novel heptablock quarterpolymers, studied by transmission electron microscopy and small angle X‐ray scattering, revealed 3‐phase 4‐layer alternating lamellae morphology of PS, PB1,4, and mixed PI3,4/PDMS domains. Differential scanning calorimetry was used to further confirm the miscibility of PI3,4 and PDMS blocks. It is the first time that PDMS is the central segment in such multiblock polymers (≥3 chemically different blocks). © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016, 54, 1443–1449
The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein
Authors: Fonseca‐Ornelas Luis , Zweckstetter Markus 
Published: May 2016

AbstractIn a group of neurodegenerative diseases, collectively termed transmissible spongiform encephalopathies, the prion protein aggregates into β‐sheet rich amyloid‐like deposits. Because amyloid structure has been connected to different prion strains and cellular toxicity, it is important to obtain insight into the structural properties of prion fibrils. Using a combination of solution NMR spectroscopy, thioflavin‐T fluorescence and electron microscopy we here show that within amyloid fibrils of a peptide containing residues 108–143 of the human prion protein [humPrP (108–143)]—the evolutionary most conserved part of the prion protein ‐ residue H111 and S135 are in close spatial proximity and their interaction is critical for fibrillization. We further show that residues H111 and H140 share the same microenvironment in the unfolded, monomeric state of the peptide, but not in the fibrillar form. While protonation of H140 has little influence on fibrillization of humPrP (108–143), a positive charge at position 111 blocks the conformational change, which is necessary for amyloid formation of humPrP (108–143). Our study thus highlights the importance of protonation of histidine residues for protein aggregation and suggests point mutations to probe the structure of infectious prion particles.
An escrow‐free online/offline HIBS scheme for privacy protection of people‐centric sensing
Authors: Chen Peixin , Su Jinshu , Zhao Baokang , Wang Xiaofeng , You Ilsun 
Published: May 2016

AbstractPeople‐centric sensing (PCS), which collects information closely related to human activity and interactions in societies, is stepping into a flourishing time. Along with its great benefits, PCS poses new security challenges such as data integrity and participant privacy. Hierarchical identity‐based signature (HIBS) scheme can efficiently provide high‐integrity messaging, secure communication, and privacy protection to PCS. However, key escrow problem and low computation efficiency primarily hinder the adoption of HIBS scheme. In this paper, we propose an escrow‐free online/offline HIBS scheme for securing PCS. By utilizing user‐selected‐secret signing algorithm and splitting the signing phase into online and offline procedures, our scheme solves the key escrow problem and achieves high scheme performance. Copyright © 2016 John Wiley & Sons, Ltd.
Psychological Vulnerability and Subjective Happiness: The Mediating Role of Hopelessness
Authors: Satici Seydi Ahmet , Uysal Recep 
Published: May 2016

AbstractThe current study examined the mediating role of hopelessness on the relationship between psychological vulnerability and subjective happiness. It was anticipated that hopelessness may act as a mediator in the relationship between psychological vulnerability and subjective happiness. Two hundred sixty‐nine (150 women and 119 men) university students completed the Psychological Vulnerability Scale, the Subjective Happiness Scale and the Beck Hopelessness Scale. Data have been collected in the 2013–2014 academic year. The present study was designed as a cross‐sectional study. Correlational results indicated that psychological vulnerability and hopelessness were significantly negatively associated with subjective happiness. Results using structural equation modelling showed that hopelessness fully mediated the relationship between psychological vulnerability and subjective happiness. Implications for future research and limitations of the present study are discussed. Copyright © 2016 John Wiley & Sons, Ltd.
Anchorage of composite dowels
Authors: Classen Martin , Hegger Josef 
Published: May 2016

AbstractIn steel‐concrete composite beams, lifting effects between the steel section and the concrete slab usually occur incidentally and have comparatively small load ordinates compared with the shear forces transferred. For this reason, lifting forces are generally irrelevant for the dimensioning of the composite joint. Nevertheless, this statement does not apply if shear connectors are used for the systematic anchorage of pull‐out forces. Although the anchorage behaviour of conventional shear connectors, e.g. headed studs, has already been studied extensively, appropriate investigations into the anchorage behaviour of concrete composite dowels are lacking, especially for composite dowels in slender or cracked concrete slabs. In this paper, the anchorage behaviour of a puzzle‐shaped concrete composite dowel is investigated in cracked and uncracked concrete. To this end, particular test setups were developed. All tests were simulated using a three‐dimensional, non‐linear finite element model. Finally, an engineering model for calculating the anchoring capacity of single composite dowels and composite dowel groups in reinforced and unreinforced concrete is presented.
Effects of transverse tension load on the static capacity and fatigue resistance of composite dowels
Authors: Kopp Maik , Pak Daniel , Feldmann Markus 
Published: May 2016

AbstractComposite dowels are powerful shear connectors in steel‐concrete composite structures, especially for prefabricated composite bridges. The advantages of composite dowels over other shear connectors are their increased strength and sufficient slip capacity even in high‐strength concrete. The National Technical Approval for Germany , from 2013 allows the design of composite structures with composite dowels for hogging and sagging moments under static and cyclic loading. However, the design of structures with cyclic loading in combination with centric tension perpendicular to the composite dowels (transverse tension) is neglected. Therefore, one part of national project P967 ”External reinforcement for composite bridges“, funded by FOSTA, the Research Association for Steel Application, was to determine how transverse tension affects the static capacity and fatigue resistance of composite dowels. To investigate this effect, two test series, each with six push‐out tests, were carried out. The test setup and the results of the static and cyclic shear tests in combination with transverse tension are presented in this paper.
Anchorage of external reinforcement in the case of rigid clamping
Authors: Luo Guoqing , Mensinger Martin 
Published: May 2016

AbstractIn the case of frame bridges with external reinforcement, the reinforcing elements have to be anchored in the abutment wall. Owing to the interaction of negative bending moment and longitudinal shear force in the abutment area, the force transfer between concrete, external steel reinforcement and normal steel reinforcement is complex. Two frame structure tests were carried out to investigate the loadbearing behaviour and rational anchorage length of external reinforcement in abutments. Two different anchorage lengths were tested, and the structural behaviour and failure modes of the two specimens were compared and analysed. The results indicate that the anchorage length has a great influence on the loadbearing capacity, and the pull‐out effect at the end of the external reinforcement should be paid special attention. The detail stress distribution and the M‐V interaction in the anchored external reinforcement were obtained from the tests and the results fit well with the theoretical calculation. Mechanical models are proposed to evaluate the pull‐out effect and optimize the anchorage length of the external reinforcement.
A new ETFE façade creates a landmark for Puebla F.C.
Authors: Aracil Llinares Mónica , Schöne Lutz , Weininger Florian 
Published: May 2016

AbstractCuauhtémoc Stadium, a first division football stadium in Puebla, México, with more than 51 000 seats, has recently been completely renovated. The brand‐new façade has become an icon for the club and for the city. The façade is designed as a skin of single‐layer ETFE foil in a combination of three different shades of blue and translucent white. The design and construction of the façade is the result of an international collaboration between local contractor DÜNN Lightweight Architecture, from Zapopan, Mexico, and LEICHT Structural engineering and specialists consulting GmbH, based in Munich, Germany. This paper will elaborate on the boundary conditions of the project and the technical decisions made for the construction of the façade.
Elastic behaviour of the steel part of a shear connection with MCL composite dowels
Authors: Kożuch Maciej , Rowiński Sławomir 
Published: May 2016

AbstractIn this paper the authors present numerical and analytical approaches for establishing rules for dimensioning MCL steel connectors for serviceability and fatigue limit states. Two unit models were adopted for the stress calculations by means of FEM: the first one for taking into account the notch effect of the longitudinal cutting line on the stress pattern in a uniformly tensioned steel plate, the second one for determining the stress pattern in a steel connector due to longitudinal shearing between the steel and concrete parts of the beam. A mathematical approach for establishing an envelope of the connector's resistance is presented. A detailed study of the fatigue behaviour of steel connectors is presented in the second part of the paper. Possible crack patterns and their development mechanisms are described, justified by appropriate FEA and test results.
Addressing the risk of maladaptation to climate change
Authors: Magnan A. K. , Schipper E.L.F. , Burkett M. , Bharwani S. , Burton I. , Eriksen S. , Gemenne F. , Schaar J. , Ziervogel G. 
Published: May 2016

This paper reviews the current theoretical scholarship on maladaptation and provides some specific case studies—in the Maldives, Ethiopia, South Africa, and Bangladesh—to advance the field by offering an improved conceptual understanding and more practice‐oriented insights. It notably highlights four main dimensions to assess the risk of maladaptation, that is, process, multiple drivers, temporal scales, and spatial scales. It also describes three examples of frameworks—the Pathways, the Precautionary, and the Assessment frameworks—that can help capture the risk of maladaptation on the ground. Both these conceptual and practical developments support the need for putting the risk of maladaptation at the top of the planning agenda. The paper argues that starting with the intention to avoid mistakes and not lock‐in detrimental effects of adaptation‐labeled initiatives is a first, key step to the wider process of adapting to climate variability and change. It thus advocates for the anticipation of the risk of maladaptation to become a priority for decision makers and stakeholders at large, from the international to the local levels. Such an ex ante approach, however, supposes to get a clearer understanding of what maladaptation is. Ultimately, the paper affirms that a challenge for future research consists in developing context‐specific guidelines that will allow funding bodies to make the best decisions to support adaptation (i.e., by better capturing the risk of maladaptation) and practitioners to design adaptation initiatives with a low risk of maladaptation. WIREs Clim Change 2016, 7:646–665. doi: 10.1002/wcc.409This article is categorized under:

Vulnerability and Adaptation to Climate Change > Learning from Cases and Analogies
Unsupervised learning of indoor localization based on received signal strength
Authors: Li Li , Yang Wang , Alam Bhuiyan Md Zakirul , Wang Guojun 
Published: May 2016

AbstractMost indoor wireless sensor network localization methods require costly site surveys to collect fingerprint information for later comparison. Moreover, due to the dynamic nature of fingerprint information in indoor wireless environments, the need for site surveys may be ongoing. In this work, indoor localization is addressed with an unsupervised learning algorithm. Our novel algorithm based on received signal strength combines the information conveyed by both range‐based and range‐free localization with state‐of‐art optimization techniques. A specially designed hierarchical Bayesian hidden Markov model coupled with a particle filter helps mitigate non‐line‐of‐sight and multipath errors. This grid‐based data sample process, derived from the theory of Dirichlet processes, simplifies the global optimization problem of unsupervised learning by employing a single initial hyper‐parameter. Meanwhile, for obtaining accurate coordinates of mobile nodes, a unique semidefinite programming method is used to provide feedback to the radio propagation model. This feedback step can enable the grid‐based algorithms not only to establish the coordinates of a mobile node, but also to optimize the accuracy iteratively. Theoretical and experimental analyses indicate that the proposed algorithm can achieve better localization accuracy than conventional range‐based algorithms without adding computation cost. Copyright © 2016 John Wiley & Sons, Ltd.
Preliminary Lichenometric Studies in Eastern and North-Western Himalaya
Authors: Bajpai Rajesh , Singh C. P. , Shukla Preeti , Upreti D. K. 
Published: May 2016

Abstract:
Lichenometry is an extremely useful technique in dating moraine ridge and recent glacier retreat in polar and alpine regions. The study relates the size of the lichen thallus to the minimum age of the exposure of the surface on which it grows which consequently helps in assessment of the age of the boulders. The Lichenometric studies are carried out in Kupup and Thangu area of eastern Himalaya in Sikkim and Thajiwas glacier in Ganderbal district of north western Himalaya of Jammu and Kashmir with the help of diameters of a common crustose lichen Rhizocarpon geographicum growing luxuriantly on exposed boulder. The Thajiwas glacier showed retreat of 200 m in 279 years while in Thangu and Kupup area of eastern Himalaya the retreat was estimated as 200 m in 100 and 91 years respectively. The rate of retreat was slightly more faster in eastern Himalayan (20 mm/century) than the north-western Himalaya region (18.5mm/century).
Estimation of Dolomite Formation: Dolomite Precipitation and Dolomitization
Authors: Banerjee Amlan 
Published: May 2016

Abstract:
Reactive-transport models are developed here that produce dolomite via two scenarios: primary dolomite (no CaCO3 dissolution involved) versus secondary dolomite (dolomitization, involving CaCO3 dissolution). Using the available dolomite precipitation rate kinetics, calculations suggest that tens of meters of thick dolomite deposits cannot form at near room temperature (25-35°C) by inorganic precipitation mechanism, though this mechanism will provide dolomite aggregates that can act as the nuclei for dolomite crystallization during later dolomitization stage. Increase in supersaturation, Mg+2/Ca+2 ratio and CO3−2 on the formation of dolomite at near room temperature are subtle except for temperature. This study suggests that microbial mediation is needed for appreciable amount of primary dolomite formation. On the other hand, reactive-transport models depicting dolomitization (temperature range of 40 to 200°C) predicts the formation of two adjacent moving coupled reaction zones (calcite dissolution and dolomite precipitation) with sharp dolomitization front, and generation of &gt;20% of secondary porosity. Due to elevated temperature of formation, dolomitization mechanism is efficient in converting existing calcite into dolomite at a much faster rate compared to primary dolomite formation.
Evaluation of Groundwater Potential Zones Using Electrical Resistivity and GIS in Noyyal River Basin, Tamil Nadu
Authors: Selvarani A. Geetha , Elangovan K. , Kumar C. Siva 
Published: May 2016

Abstract:
The purpose of this study was to identify the groundwater potential zones in Noyyal river basin using GIS and electrical resistivity. River Noyyal was perennial with good flow till early seventies. In recent years, the scene has changed drastically and the river has become practically seasonal and receives copious water during northeast monsoon from September to November. The rest of the years it remains more or less dry. Since the surface water resources in the area are inadequate to meet the local needs it is necessary to explore groundwater resources which has not been done properly. Hence various thematic maps have been used for the preparation of groundwater prospective map by integrating geology, geomorphology, slope, drainage and lineament of the study area. Electrical resistivity survey was conducted at 52 locations by using Schlumberger configuration. From this weathered thickness and depth to basement have been taken and overlaid for identifying groundwater potential sites and finally this result was compared with yield data. The interpretation shows that the entire study area has moderate to good category of groundwater potential.