bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preclinical evaluation of targeted therapies for central nervous system metastases
Authors: Pfeil Alexander J. , Hale Joshua D. , Zhang Tiger S. , Wakayama Kentaro , Miyazaki Isao , Odintsov Igor , Somwar Romel 
Published: September 2024

ABSTRACT
The central nervous system (CNS) represents a site of sanctuary for many metastatic tumors when systemic therapies that control the primary tumor cannot effectively penetrate intracranial lesions. Non-small cell lung cancers (NSCLCs) are the most likely of all neoplasms to metastasize to the brain, with up to 60% of patients developing CNS metastases during the disease process. Targeted therapies such as tyrosine kinase inhibitors (TKIs) have helped reduce lung cancer mortality but vary considerably in their capacity to control CNS metastases. The ability of these therapies to effectively target lesions in the CNS depends on several of their pharmacokinetic properties, including blood–brain barrier permeability, affinity for efflux transporters, and binding affinity for both plasma and brain tissue. Despite the existence of numerous preclinical models with which to characterize these properties, many targeted therapies have not been rigorously tested for CNS penetration during the discovery process, whereas some made it through preclinical testing despite poor brain penetration kinetics. Several TKIs have now been engineered with the characteristics of CNS-penetrant drugs, with clinical trials proving these efforts fruitful. This Review outlines the extent and variability of preclinical evidence for the efficacy of NSCLC-targeted therapies, which have been approved by the US Food and Drug Administration (FDA) or are in development, for treating CNS metastases, and how these data correlate with clinical outcomes.
Case Report: Pathological fracture in a Li-Fraumeni osteosarcoma patient: "Capasquelet'' femoral reconstruction and tumor vascular analysis with endomucin immunofluorescence multiplexing
Authors: Tran Guillaume , Amiaud Jerome , Combal Alexis , Duteille Franck , Redini Françoise , Verrecchia Franck , Crenn Vincent 
Published: September 2024

We describe the case report of an Osteosarcoma patient, with a Li-Fraumeni Syndrome, presenting with a pathological femoral fracture. The patient was treated with a multidisciplinary approach associating neoadjuvant and adjuvant chemotherapy with excisional surgery. The femoral reconstruction consisted of a ``Capasquelet'' reconstruction combining an induced membrane and a vascularized fibula allograft allowing a good functional result with an early weight-bearing. We managed to complete our histological analysis in this patient, in order to evaluate the tumor vascularization. Indeed, using the syngeneic osteosarcoma MOS-J mouse model, we highlighted previously that CD31+/\ensuremath{\alpha}-SMA+ vessels may be indicators of vasculature normalization and therefore may be used as specific markers of a good therapeutic response. Thus, we search for its interest in this specific case as preliminary work. The aim was to assess the feasibility and technical validity of the vascularization analysis of a human osteosarcoma tumor specimen. Therefore, we propose an immunohistochemistry methodology with multiplexed immunofluorescence to assess the vascularization as a promising marker in human osteosarcoma tissue.
Review article: Comparison of cosmetic regulatory policies in various countries toward consumer protection
Authors: Putri Kintan Amelia Asmoro , Segita Nur Elisa , Nuryadin Raissa Nuraini , Saputra Rio Dimas , Nur Yasmin Lutfiah , Silvia Deli 
Published: September 2024

Cosmetics are various products that enhance physical appearance and care for the skin, hair, and body. Cosmetic regulation refers to the rules and regulations imposed by a country's government or health regulatory agencies to regulate the production, marketing, and use of cosmetic products. The purpose of writing this journal is to compare the regulation of cosmetic products in Indonesia with the regulation of cosmetic products abroad, and it is hoped that people will be more aware and understand the regulation of cosmetic products that have been established. The literature method is used to conduct a review article, and the criteria chosen are based on the originality and relevance of the reading. The result of this writing is that the requirements regarding labeling in various countries are similar, such as composition, country of manufacture, product name, instructions for use, full name and address of the owner of the notification number (manufacturer), manufacturing batch number, expiration date, and special precautions that must be considered when using. Consumers must consider different regulations for cosmetic products in each country. These must be considered when making or selling cosmetic products: import and export regulations, limited ingredients, and safety testing of cosmetic products.

Keywords: Cosmetics, Export, Import, Labelling, Regulation
The importance of drug symbols and halal logos in the pharmaceutical industry: Effect, understanding, and implementation
Authors: Ramadan Hendra , Harbit Auratul Atifah , Azizah Siti Nur 
Published: September 2024

With its predominantly Muslim population, Indonesia has significant potential in pharmaceuticals and herbal products, making it a focal point for government initiatives to drive growth in the sector. Despite these efforts, compliance with halal standards and obtaining halal certificates still face many challenges. This research examines the efforts to fulfill halal certification obligations by implementing halal standards in pharmaceutical and herbal products. This research uses a descriptive qualitative study; the data was collected through observational reviews and interviews and supplemented with a comprehensive literature study, which includes various sources such as journals, books, online media, and other additional references. This study reveals that setting standards or halal certification involves three parties, namely the Halal Product Assurance Organizing Agency (BPJPH), the Halal Examining Agency (LPH), and the Indonesian Council of Ulama (MUI). BPJPH implements the halal product guarantee. Then BPJPH will submit it to Lembaga Pengkajian Pangan, Obat-obatan dan Kosmetika (LPPOM) as LPH to check the adequacy of documents, compile audits, conduct audits, hold auditor meetings, issue audit memoranda, and submit audit result records to the MUI Halal Fatwa Session. Together with the Fatwa Committee, MUI determines the level of halalness of the product based on the audit results and issues a MUI Halal Decree.

Keywords: Herbs, Halal Industry, Halal Certificate, Medicines
Crossed-cell-tile multiplexed 1st-order gratings, for three-dimensional beam-splitter applications
Authors: Subash Uma , Poutous Menelaos K. 
Published: September 2024

Oblique angle of incidence two-way and three-way beam splitters were designed and fabricated. The devices feature two first-order diffraction gratings, arrayed crossed in alternating adjacent tiles, resulting in conical diffraction spot separation of two 1
st
-orders in orthogonal planes while overlapping the 0
th
-order. The two-way beam splitter was designed for 0
th
−order suppression. The three-way beam splitter was designed to distribute light equally between the 1
st
and 0
th
− order spots. Testing of the devices yielded efficiencies of 2%:46%:46% for the two-way beam splitter at 604 nm, and 32%:32%:32% for the three-way beam splitter at 633 nm wavelength. The polarization state of the incident beam was preserved after diffraction through the devices.
Concocting Teleology in Aristotle’s
Meteorology
4 and
Generation of Animals
Authors: Kress Emily Nancy 
Published: September 2024

Abstract
Aristotle claims that in making an animal, nature acts like a “good housekeeper” who “is accustomed to throw out nothing from which it is possible to make something useful” (744b16–17). How does nature act when it “make[s] something useful” in these cases – and does it differ from other ways it acts? I defend two main claims. The first is that Meteor. 4.2’s distinction between two sorts of ‘concoction’ processes offers an underappreciated source of evidence for answering this question. My second claim concerns the nature of those processes and the ends they realize. While they are both the ends of their respective types of concoction, they differ in that some essential (process-defining) features of the second end – but not the first – are supplied by what the capacities of the “underlying” patient (on which the agent acts) are for. The result is a distinction between two kinds of end-directed efficient causation.
Modeling process for full forming sports underwear
Authors: Honglian Cong , Xiaowen Wu , Xian Huang , Qiudong Pan 
Published: September 2024

Abstract
Most of the sports underwear available is sewn using cutting and sewing techniques. During the exercise process, it is easy to cause discomfort to the skin due to repeated friction at the seam, and at the same time, it is also a waste of manpower and raw material costs. In order to address these issues present in existing sports underwear, during its design and development, combined with fully forming knitting technology, construction process model, so as to realize the integrated knitting of sports underwear. First of all, through the characteristics of the local style of sports underwear, the key points of its prototype were probed. Second, on this basis, its process model was established, including the forming methods and knitting rules of the body, shoulder collar, and bottom circumference. Finally, the feasibility of the technological model is proved by the braiding of a fully formed sports underwear. The change in the body size can be achieved by using the two-side braiding transfer method. The curve contour of the shoulder and neck can be obtained by using the triangular polyline segmentation method. The bottom part is divided into a cylinder part and a supporting part. The local braiding method is used to achieve the knitting. This study puts forward a process model and application method of fully formed sports underwear, which provides a certain method and reference for the design and production of fully formed sports underwear.
Theoretical and experimental comparison between straight and curved continuous box girders
Authors: Dawood Asala Asaad , Abdul-Razzaq Khattab Saleem , Abdulsahib Wael Shawky 
Published: September 2024

Abstract
The curvature causes a variation in the deflection of the outer and inner sides. The effect of curvature was investigated by casting and testing two specimens with the same section – one straight and the other horizontally curved continuous box girder. ABAQUS software was used to numerically model the box girder in order to verify the model and investigate additional parameters. Numerical modeling is successful with less effort, cost, and time because good results are obtained. The effect of the span-to-depth ratio, the compressive strength of concrete, and the percentage of stirrup steel reinforcement was studied numerically. Increasing the height, compressive strength, and percentage of stirrup steel led to a significant increase in load capacity and stiffness. The load capacity in the curved specimen decreased by 11% compared to the straight one due to the effect of torsional moments. A mathematical model was proposed based on the theory of strut-and-tie modeling (STM), where the span was divided into several panels, the effect of torsion was added, and then the results were compared with the traditional sectional method according to ACI and CEB-FIB. For the straight specimen, the sectional ACI, CEB-FIB, and STM methods were used, which gave theoretical results less than the experimental by 31, 48 and 13%, respectively. For the curved specimen, to get closer to reality, the sectional and STM methods were modified by adding the effect of torsion, and the results were less than the experimental tests by 43, 61 and 22%, respectively.
Green stability-indicating RP-HPTLC technique for determining croconazole hydrochloride
Authors: Alam Prawez , Shakeel Faiyaz , Alshehri Sultan , Alhaiti Ali , Alqarni Mohammed Hamed , Foudah Ahmed Ibrahim , Aljarba Tariq Mohammed , Abdel Bar Fatma Mohamed 
Published: September 2024

Abstract
The objective of the proposed investigation is the development and validation of a green stability-indicating reverse-phase high-performance thin-layer chromatographic method to determine croconazole hydrochloride (CCZ). The developing system used was an 80:20 v/v mixture of acetone and water. The measurement of CCZ was done at 198 nm. With the use of the Analytical Eco-Scale (AES), ChlorTox, and Analytical GREEnness (AGREE) tools, greenness was evaluated. The linearity was demonstrated by the present method in the 25–1,200 ng/band range. The present approach was additionally reliable, accurate, sensitive, precise, and green. An exceptional greenness profile was demonstrated by the AES, total ChlorTox, and AGREE scales, which were determined to be 89, 1.08 g, and 0.82, respectively. The greenness metrics of the present method were much better than the reported high-performance liquid chromatography approach. Under acid and oxidative degradation circumstances, CCZ was shown to be unstable, while under alkaline and thermal-stress settings, it was sufficiently stable. Furthermore, the stability-indicating component determined by analytical method identified CCZ in the presence of its degradation products. Commercial CCZ cream was found to contain 0.98% w/w of CCZ. The investigation’s results suggested that CCZ in commercially available creams might be regularly examined with the help of the recommended green technology.
Interpretation of TSH results can be improved by reference values fluctuating in time
Authors: Delanghe Joris R. , Van Elslande Jan , Godefroid Maaike , Speeckaert Marijn M. , Maenhout Thomas M. 
Published: September 2024

Abstract

Objectives
The secretion of thyroid stimulating hormone (thyrotropin, TSH), is characterized by a marked circadian rhythm. Plasma or serum TSH values are significantly lower in the afternoon and in the evening as compared to the early morning. As in clinical practice, blood sampling time shows an important variation, a reliable assessment of thyroid status is often not an easy task for the clinician. The biological variation of TSH plays a major role in the intra-individual variability of TSH results in serum or plasma. The observed intra-day variation largely exceeds the reported inter-vendor variation and the coefficient of variation of clinical TSH assays. Therefore, a mathematical solution was sought for correcting interpretation of TSH results for sampling time.

Methods
We have developed a cosinor model which allows to compensate TSH decision values for the fluctuating serum or plasma TSH concentrations throughout the day.

Results
The following mathematical function could be derived: corrected TSH cutoff_value (mIU/L)=0.40 + 0.24*cos(((π/12) *T) + 6) in which T represents the time (hours). This mathematical function can be easily implemented into a laboratory’s informatics system and furthermore allows a better tailored diagnosis of (subclinical) hyperthyroidism, regardless the blood sampling time.

Conclusions
Implementing the corrected cut-off values result in a marked reduction of apparent (false positive) hyperthyroidism diagnosis, in particular in the afternoon.
Avocado peel by-product in cattle diets and supplementation with oregano oil and effects on production, carcass, and meat quality
Authors: Mendez-Zamora Gerardo , Sinagawa-García Sugey R. , Luna-Maldonado Alejandro Isabel , Kawas Jorge R. , Rico-Costilla Daniela Saraí , Castillo-Velázquez Uziel , Preciado-González Eduardo , Martinez-Rojas Jimena 
Published: September 2024

Abstract
The objective of this work was to evaluate the effects of including a commercial avocado peel meal (Avomel) by-product as a feed source supplemented with Lippia berlandieri Schauer oregano essential oil (OEO) in cattle diets. Eighteen 22-month-old male Charolais x Angus crossbred cattle (334.96 ± 27.48 kg) were randomly distributed in three experimental groups (n = 6): Control, cattle fed with the control diet without Avomel and without OEO; Avomel, cattle fed 10% of Avomel in the diet; and Avomel + OEO, cattle fed 10% Avomel and 600 mg/kg of OEO in the diet. The evaluated variables were bulls’ weight (BW), feed intake (FI), slaughter variables, carcass quality and the pH, water holding capacity (WHC), color and chemical composition of raw rib eye meat, as well as cooking loss (CL), shear force (SF), texture analysis and sensory evaluation of cooked meat. After 120 days of feeding, BW was highest (P < 0.10) for Avomel and lowest (P < 0.10) for Avomel + OEO. The Avomel + OEO group FI was low. Cattle slaughter variables, carcass quality variables, pH, and WHC did not show differences (P > 0.05). Lightness was highest (P < 0.05) for Avomel meat. Meat chemical composition was not affected (P > 0.05). SF of meat was different (P < 0.05) being highest for Avomel + OEO. On meat texture, springiness was different (P < 0.05), i.e., meat treated with Avomel was highest, but no differences (P > 0.05) were detected for hardness, adhesiveness, cohesiveness, gumminess, chewiness, and resilience. Odor, taste, softness, juiciness, and overall acceptability of cooked meat were not different (P > 0.05), data not shown. The commercial by-product avocado peel meal supplemented with OEO could be used in cattle diets without adversely affecting productive performance, carcass traits, and meat quality.
Catalyst efficiency through the disorder kinetics to identify its nonlinearity in their properties of Ag3PO4@TiO2 catalyst using UV–visible spectroscopy
Authors: Vinothkumar Panjanathan , Sivakumar Thirumuruganantham , Praveenkumar Sukumar , Ramalingam Parameshwari , Alharethy Fahd , Suganthi Sanjeevamuthu , Oh Tae Hwan , John Anu Kattappana 
Published: September 2024

Abstract
Photocatalysis has a significant role in water remediation. During the process of photocatalysis, catalysts face different problems, such as instability and inefficiency. Here, we are introducing a new method, ‘nonlinearity kinetics’, which will help to identify this kind of problem during photocatalytic activity. We are considering Ag3PO4@TiO2 to study nonlinear disorder kinetics. Ag3PO4 is a highly photoactive compound with an inherent photocorrossive nature. Here, it addresses the challenge of pure Ag3PO4 by transforming composite materials to Ag3PO4@TiO2 and by studying its nonlinear kinetics during photocatalysis. The Ag3PO4@TiO2 underwent preliminary characterisation. Increment of crystalline nature studied through XRD. FESEM and TEM analysed morphological alignment and diffraction patterns. The functional behaviour of oxygen, Ag, Ti and P–O–P were identified through the FT-IR spectra. The reduced optical band gap Ag3PO4@TiO2 was 2.9 eV Obtained from the UV–visible spectra. Photocatalysis activity was performed, and newly introduced disorder kinetics were observed. The nonlinear fit of the kinetics shows a shift over time (intercept value of linear fit −0.27) that indicates the corrosive characteristics. For an efficient catalyst, this value must be equivalent to zero. The photocorrossive disorder kinetics study demonstrates the disorder and nonlinearity of the catalyst and catalytic medium when it does not fit with a linear fit. To identify a disorder, it is important to look at the disorder kinetics of analysis.
Fecundity difference is related to the production of reproductive pheromones in rats
Authors: Yamada Toshiyuki , Ando Aya , Morita Ryusuke , Sako Ken-Ichi , Tsuchida Shigeki , Yamamoto Hiroyuki 
Published: September 2024

In brief
Social and reproductive behaviors in mammals are regulated by pheromones. This study shows the possibility that male extraorbital lacrimal gland-derived pheromones are involved in reproductive efficiency in rats.

Abstract
In rodents, male-derived pheromones play fundamental roles in reproduction. The Hirosaki hairless rat (HHR) is a mutant strain derived from the Sprague–Dawley rat (SDR). While investigating the natural mating between single males and females, (SDR♂ × SDR♀) or (HHR♂ × HHR♀), the HHRs showed higher fecundity than the SDRs; the mean period between mating and delivery was shorter, and every HHR pair gave birth, whereas approximately half of the SDR pairs gave birth in the 3 months of experimental testing. By changing partners between the HHRs and SDRs, (SDR♂ × HHR♀) or (HHR♂ × SDR♀), we attributed the fecundity difference to the males. However, no significant difference was observed in the litter size, the concentration, morphology, or motility of sperm in the cauda epididymis, or the testosterone concentration in the serum between the SDR and HHR males. When an SDR and HHR male were simultaneously mated with a single female, the HHR males always succeeded in leaving progeny. Therefore, we assumed that the reason for the fecundity difference was the difference in copulation efficiency and focused on male-derived pheromones that may induce reproductive behaviors in females. Whereas Darcin (MUP20), one of the pheromones produced in the liver, did not appear to be involved, the extraorbital lacrimal gland (ELG) was heavier in the HHR males and showed larger amounts of pheromones, namely exocrine gland-secreting peptide 1 (ESP1) and cystatin-related protein 1 (CRP1). These results suggest that the fecundity difference is due to the difference in amounts of ELG-derived pheromones.