bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cervical myeloid sarcoma as an initial clinical manifestation: Four case reports
Authors: Li Jin-Ke , Wang Xiao-Xue , Fu Jia-Jun , Zhang Dan-Dan 
Published: September 2024

BACKGROUND
Cervical myeloid sarcoma (MS) is a rare hematological malignancy characterized by the formation of extramedullary soft tissue masses in the cervical region. Due to its uncommon presentation in the female reproductive system, cervical MS poses significant diagnostic and therapeutic challenges. Consequently, there is a pressing need for more research and clinical experience to better understand, diagnose, and manage this condition effectively.
CASE SUMMARY
This report details four cases, the diagnostic process, treatment strategy, and outcomes, discussing cervical MS as an initial clinical manifestation. The disease exhibits varied clinical presentations, such as irregular vaginal bleeding and palpation of cervical masses. The treatment approaches discussed include neoadjuvant chemotherapy, surgery, and postoperative chemotherapy, though managing the disease remains challenging. The report also features a comprehensive literature review that underscores the importance of immunohistochemistry for accurate diagnosis, identifying key markers, including myeloperoxidase, cluster of differentiation (CD) 68, and CD43, stressing the need for further research to improve treatment strategies and prognosis.
CONCLUSION
Immunohistochemical diagnosis and tailored therapeutic strategies are essential. Further research is crucial in improving outcomes and developing effective treatment protocols.
Perioperative management of postoperative sigmoid colon cancer complicated by a large abdominal wall defect: A case report
Authors: Zhu Yan-Ling , Li Rui , Cheng Yuan-Guang , Wang Ya-Fei 
Published: September 2024

BACKGROUND
Large abdominal wall defect (LAWD) measures > 20 cm in width. LAWD can easily lead to intestinal necrosis, peritonitis, other complications, and even multiple organ dysfunction syndrome. Multiple intestinal fistulas are high-flow fistulas that can cause severe water–electrolyte imbalance and malnutrition, as well as inflammation, high metabolic status, and chronic intestinal failure caused by intestinal fluid corrosion in tissues around the orifice fistulas.
CASE SUMMARY
This article summarizes the nursing experience of a patient with sigmoid carcinoma who has LAWD with multiple intestinal fistula due to repeated operations for postoperative complications. The key points of care: Scientific assessment of nutritional status, dynamic adjustment of nutritional support programmes, comprehensive adoption of enteral nutrition, parenteral nutrition and combined nutrition of enteral and parenteral; taking good care of abdominal wall defects and intestinal fistulas; continuous flushing of the abdominal drainage tube and low negative pressure drainage; prevention of venous thrombosis; strengthening of physical exercise; implementation of positive psychological interventions.
CONCLUSION
After more than 7 months of careful care, the patient's physical fitness has been well recovered, local inflammation is well controlled, which wins the opportunity for the operation, and the postoperative recovery is good.
Hypofractionated and intensity-modulated radiotherapy combined with systemic therapy in metastatic hepatocellular carcinoma: A case report
Authors: Chen Qiu-Qiu , Chen Chun-Qiao , Liu Jin-Kun , Huang Ming-Yue , Pan Min , Huang Hui 
Published: September 2024

BACKGROUND
Liver cancer treatment is characterized by multidisciplinary participation and coexistence of multiple treatment methods. Hypofractionated and intensity-modulated radiotherapy is a new precise radiotherapy technique applied to the treatment of systemic malignant tumors. There is a lack of understanding of hypofractionated and intensity-modulated radiotherapy combined with systemic therapy in metastatic hepatocellular carcinoma (HCC).
CASE SUMMARY
We report a case of metastatic HCC treated with hypofractionated and intensity-modulated radiotherapy combined with systemic therapy. A 41-year-old man was diagnosed with metastatic HCC (T3N1M1 stage IVB). Because it was found to be in the late stage of cancer and had already metastasized, it was impossible to undergo surgical treatment. In addition to aggressive comprehensive treatment for the primary lesion, local treatment for metastatic cancer can improve the patient's survival potential. Hypofractionated and intensity-modulated radiotherapy can provide a larger single treatment dose within a shorter overall treatment time, and improve the local control rate of the tumor. Follow-up examination demonstrated that the tumor and metastatic lesions had shrunk after therapy. The treatment has showed good efficacy. The patient survived for 18 months without disease progression and stable disease persisted for > 38 months.
CONCLUSION
Targeted therapy and immunotherapy followed by hypofractionated and intensity-modulated radiotherapy are also effective for advanced metastatic HCC.
Disitamab vedotin combined with apatinib in gastric cancer: A case report and review of literature
Authors: Li Xiao-Qian , Yang Jing , Liu Bo , Han Shu-Mei 
Published: September 2024

BACKGROUND
In patients with human epidermal growth factor receptor 2 (HER2)-overexpressing gastric cancer (GC), the combination of HER2 targeting and a standard first-line chemotherapy regimen has been demonstrated to significantly improve their prognosis. However, in a proportion of patients, cancer progresses within a short period of time, and there is currently no standard treatment after disease progression.
CASE SUMMARY
This study presents a case of a 51-year-old male with advanced GC who underwent radical resection (Billroth type II subtotal gastrectomy and gastrojejunostomy) and resection of liver metastases. Immunohistochemical staining revealed a HER2 score of 2+, a dMMR status, and a Ki67 proliferation index of 30% to 40%. The gene test results indicated the presence of ERBB2 amplification and a PD-L1 expression level of less than 5%. Since December 2021, the patient has experienced disease progression during both first-line (two cycles of KN026 combined with KN046) and second-line (five cycles of nivolumab combined with trastuzumab and SOX chemotherapy) treatment regimens. The patient's prognosis following the first and second lines of treatment was unfavorable, with progression occurring in a relatively short time. For third-line therapy, disitamab vedotin (RC48) plus apatinib was used. At the time of this report, the patient had achieved a progression-free survival (PFS) of 25.8 months, which exceeded the median survival time for patients with advanced GC.
CONCLUSION
Despite the unfavorable prognosis associated with advanced GC, the implementation of personalized treatment approaches may still prove beneficial for select patients. In patients with HER2-positive GC with extensive metastatic involvement, the use of the HER2-targeted combination with apatinib has demonstrated the potential to prolong both PFS and overall survival.
Vaginal clear cell adenocarcinoma in Herlyn-Werner-Wunderlich syndrome: A case report
Authors: Lei Xian-Gao , Zhang Heng 
Published: September 2024

BACKGROUND
Herlyn-Werner-Wunderlich (HWW) syndrome is a rare Müllerian duct anomaly, characterized by a combination of urogenital abnormalities. The occurrence of primary cervico-vaginal carcinomas in patients with HWW syndrome is exceptionally rare, posing significant challenges for screening, early diagnosis, and effective management.
CASE SUMMARY
We report a rare case of primary clear cell carcinoma of the vagina complicated in a 40-year-old woman with HWW syndrome. The patient presented with irregular vaginal bleeding for 4 years. On gynecological examination, an oblique vaginal septum was suspected. Surgical resection of the vaginal septum revealed a communicating fistula and a tumor on the left vagina and the left side of the septum, which was confirmed as clear cell carcinoma. One month later, she underwent a radical hysterectomy, vaginectomy, bilateral salpingo-oophorectomy, and pelvic lymph node dissection. Due to significant side effects, she completed only one course of chemotherapy. A year later, lung metastasis was detected and continued to grow. A thoracoscopic wedge resection of the right upper lobe was performed 4 years after the initial surgery. We also conducted a systemic review of the literature on primary cervical or vaginal carcinoma in HWW syndrome to explore this rare entity.
CONCLUSION
Cervico-vaginal adenocarcinomas in patients with HWW syndrome are occult, and require early surgical intervention and regular imaging surveillance.
Digital Marketing and Consumer Nutritional Behavior
Authors: Kömürcü Aysu , Özdil Dilara , Botsali Ahmet Reha , Önay Derin Didem 
Published: September 2024

Digital marketing involves promoting and selling products and services online and it is becoming extremely critical for retailers to gain new customers. Digital marketing uses online platforms, e-mail communications and messaging services, advertisements, and multi-modal online techniques. Digital marketing techniques can be used in parallel with machine learning and artificial intelligence to provide more effective results in analyzing customer behavior. Artificial intelligence (AI) has become an important and popular tool in the 21st century, affecting almost every sector, including engineering, science, medicine, business, finance, and marketing. However, AI’s dominance in every field of life, especially in digital marketing, may cause some ethical concerns related to consumers. In addition to these moral concerns, digital marketing creates doubts about its negative impact on human health. For this reason, understanding consumer behavior and providing products according to consumer needs has become indispensable for companies today. Digital marketing is everywhere in our daily lives and is also frequently used in the food industry. Through digital marketing, food industries promote the consumption of foods that are particularly high in energy and poor in nutrients. Consequently, individuals exposed to digital marketing in the food industry may be prone to obesity-related problems. This study analyzes the relationship between digital marketing, AI, and consumer behavior specifically on eating habits along with references from the literature.
KONSENTRASI AIR JERUK PERAS (Citrus sinensis) PENGGANTI ASAM LARUTAN TURK UNTUK HITUNG JUMLAH LEUKOSIT
Authors: Rahmayanti Rahmayanti , Wahab Irwana , Fajarna Farah , Nazir Nazir 
Published: September 2024

Pemeriksaan hitung jumlah leukosit manual biasanya menggunakan larutan Turk dengan komposisi asam asetat glasial, gentian violet dan aquadest. Larutan Turk secara umum berfungsi sebagai pengencer dan melisiskan sel-sel selain leukosit. Jeruk peras (Citrus x sinensis) memiliki kandungan asam sitrat yang sifat keasamannya hampir sama dengan asam asetat yaitu mempunyai sifat keasaman lemah yang dapat dijadikan pengganti asam asetat pada komposisi larutan Turk. Tujuan penelitian yaitu untuk mengetahui variasi konsentrasi air perasan jeruk peras (Citrus x sinensis) pada konsentrasi 2%, 3%, 4% dan 5% sebagai pengganti asam pada komposisi larutan Turk dalam hitung jumlah leukosit. Penelitian ini bersifat penelitian dasar murni (basic research) yang laboratorik dan dilaksanakan pada bulan Oktober 2023 di Laboratorium Patologi Jurusan Teknologi Laboratorium Medis Poletekkes Kemenkes Aceh menggunakan teknik purposive sampling. Pengumpulan data dilakukan dengan cara deskriptif yaitu dengan cara membuktikan berapa persen konsentrasi efektif digunakan untuk hitung jumlah leukosit, lalu data disajikan dalam bentuk tabulasi. Setelah dilakukan penelitian diperoleh bahwa variasi konsentrasi air perasan jeruk peras (Citrus x sinensis) dapat digunakan sebagai bahan alternatif pengganti komposisi larutan Turk untuk hitung jumlah leukosit dan efektif pada semua konsentrasi 2%, 3%, 4% dan 5%, namun jumlah leukosit yang paling banyak diperoleh pada konsentrasi 2% dimana inti leukosit terlihat jelas dan mudah untuk dihitung.
ANALISIS HASIL KONTROL KUALITAS PEMERIKSAAN HEMOGLOBIN DAN HEMATOKRIT
Authors: Wulandari Elsa , Astuti Tri Dyah , Hadi Wahid Syamsul 
Published: September 2024

Untuk menjamin hasil pemeriksaan yang benar, mekanisme kontrol yang dikenal sebagai aktivitas pemantapan mutu internl (PMI) diterapkan untuk menghindari atau menghilangkan kesalahan dan penyimpangan. Secara khusus, laboratorium sering melakukan uji hemoglobin dan hematokrit. Hematology Analyzer otomatis yang digunakan untuk pengujian ini berpotensi memberikan hasil pembacaan hematokrit dan hemoglobin dengan kesalahan pembacaan. Untuk menjamin hasil yang tepat, prosedur kontrol kualitas dapat mengidentifikasi kesalahan ini. Hasil kontrol kualitas hemoglobin dan hematokrit, termasuk presisi dan akurasi, serta bagan kontrol Levey-Jennings, aturan Westgard, dan nilai metrik sigma, menjadi fokus investigasi ini. Data sekunder dari pemeriksaan kontrol kualitas harian hemoglobin dan hematokrit yang dilakukan dengan Hematology Analyzer Mindray BC-6200 dan bahan kontrol komersial pada tingkat normal pada bulan Januari, Februari, dan Maret 2024 digunakan dalam penelitian ini, yang menggunakan metode deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa pemeriksaan hematokrit memiliki nilai bias sebesar 2,08%, -0,13%, dan 0%, sedangkan pemeriksaan hemoglobin memiliki nilai bias sebesar 0,16%, 0%, dan 0,41%. Untuk pemeriksaan hemoglobin, CV sebesar 0,57%, 0,65%, dan 0,57%; untuk pemeriksaan hematokrit sebesar 1,08%, 0,87%, dan 0,79%. Hasil perbandingan grafik Levey-Jennings dengan aturan Westgard menunjukkan bahwa nilai kontrol—khususnya, 12s, 13s, dan 22s—melebihi ketentuan Westgard. Pemeriksaan hematokrit memiliki nilai metrik sigma lebih dari 4, dan pemeriksaan hemoglobin memiliki nilai metrik sigma lebih besar dari 6. Ini menunjukkan bahwa kedua tes tersebut memiliki kualitas yang baik, dengan pemeriksaan hemoglobin memiliki kualitas yang lebih tinggi dimana nilai sigma yang lebih tinggi menunjukkan variasi yang lebih kecil dan kualitas yang lebih baik.
Study on Performance Simulation Matching of One-Dimensional Hydrogen Storage and Supply System for Hydrogen Fuel Cell Vehicles
Authors: Liu Qi , Xiong Biao , Liu Yuxuan , Zhang Chuanyu , Yuan Shuo , Ma Wenshang 
Published: September 2024

Article
Study on Performance Simulation Matching of One-Dimensional Hydrogen Storage and Supply System for Hydrogen Fuel Cell Vehicles

Qi Liu 1,2, * , Biao Xiong 1,3, Yuxuan Liu 1,3, Chuanyu Zhang 1,3, Shuo Yuan 1,2, and Wenshang Ma 1,3

1 College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, China
2 Research Institute of Hunan University in Chongqing, Chongqing 401120, China
3 State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, Hunan University, Changsha 410082, China
* Correspondence: author: hnuliuqi@hnu.edu.cn

Received: 1 July 2024; Accepted: 12 September 2024; Published: 27 September 2024

Abstract: With the improvement of environmental protection requirements, hydrogen fuel cell vehicles are considered one of the most potential and promising new energy vehicles because of their advantages, such as pollution-free emission, long cruising range, and short hydrogenation time. However, there are still unresolved problems between the storage and supply of hydrogen and the power demand during the operation of hydrogen fuel cell vehicles. In this study, a hydrogen fuel cell vehicle is taken as the research object, and a one-dimensional model is built according to the basic performance parameters so as to explore the operation law of the power performance demand of the hydrogen fuel cell vehicle, simulate the power demand in the actual operation process, summarize the influence of different parameters on the power economic performance of the vehicle, and put forward optimization strategies to improve the power, durability, and fuel economy of the vehicle.
Snyder Hopes the Application of Theoretical Model of Nursing Intervention in Patients with Brain Malignancy Surgery
Authors: Zhang Liying , Yang Changmei 
Published: September 2024

Explore the application value of nursing intervention based on Snyder hopes theory in patients with brain malignancy surgery. Methods The 110 cases of patients with brain malignancy who were treated in our hospital from January 2023 to January 2024 were selected as a study object. They were randomly divided into observation group and control group. The control group was received routine nursing. The hope theoretical intervention was performed on this basis in the observation group. The Herth hope index (HHI), self - rating anxiety scale (SAS), self - rating depression scale (SDS) and self-feeling burden scale (SPBS) scores of the two groups were compared before and after intervention. Both groups were followed up for 6 months, using the Concise Questionnaire for Psychological Adaptation of Cancer Patients (Min-MAC-19) and the Quality of Life Scale for Brain Tumor Patients (QOL-C30) to assess the improvement of patients' psychological adaptability and quality of life. Results After intervention, the SAS, SDS, and SPBS scores of the two groups were significantly reduced, and the HHI score was significantly increased. The SAS, SDS, and SPBS scores of the observation group were significantly lower than the control group, and the HHI score was significantly higher than the control group. The differences were statistically significant (P<0.05); After 6 months of follow-up, the observation group Min-MAC-19 and QOL-C30 scores were significantly higher than the control group (P<0.05). Conclusion Nursing intervention based on Snyder's hope theory can improve the mental state of patients after brain malignancy surgery, reduce the patient's self-experience burden, improve their hope level, psychological adaptability, and improve the quality of life of patients.
Improving the Performance of Islamic Banking through Technological Innovation and Human Resource Management
Authors: Muheramtohadi Singgih , Fataron Zuhdan Ady 
Published: September 2024

This study base on few islamic banks those aplicate syariah law in runing their business. And the question is what the reason the principal of syaria would be executed? Which human resources those will be prepared to for running syariah bank activities? How the application of technology in assistance of bank syariah performance? The results of study are those; many syaria bank run its system not much different from commercial banks. Just change many terms in arabic language. This happen cause the commercial bank system easier and safer than syariah system. To run the syaria system, so be required better quality resources in running of businesss more than comercial banks. So, it need some analysis experts and business supervisors those more professional, to reduce the level of loses. Beside that, with the assistance of technology can help in coordination and communication with other people, especiallly between shohibul mal. Mudharib and partnership
The advancement and future outlook of bioremediation techniques for locations contaminated with petroleum and petrochemicals
Authors: Zhou Qixing , Zhan Haiyin 
Published: September 2024

<p>The exploitation of petroleum assets fuels economic and societal progress, but it also leads to extensive contamination of land with oil and petrochemicals, which increasingly threatens the environmental integrity of these areas. Bioremediation has emerged as a favored approach for addressing this issue due to its environmentally benign nature and absence of secondary pollution. This discourse encapsulates the latest advancements in bioremediation strategies, particularly those involving microbial and phytoremediation techniques for tackling petroleum and petrochemical contamination. It also examines the constraints of current bioremediation practices and envisions future research directions. The objective is to enhance the efficacy of bioremediation for contaminated sites and to establish a scientific foundation that will support the evolution and comprehensive application of bioremediation technologies.<strong></strong></p>
Investigation into the correlation between agricultural non-point source pollution and economic expansion in Xinjiang: A Kuznets Curve analysis
Authors: Zhang Xiao-li , Xia Yire , Xiao Kaiti 
Published: September 2024

<p>This study employs the output coefficient method to estimate the agricultural non-point source pollution load in Xinjiang and further analyzes its Environmental Kuznets Curve (EKC) characteristics. The objective is to conduct empirical research on the relationship between livestock, planting, rural living, and economic growth. The results indicate that: (1) The agricultural non-point source pollution load in Xinjiang, in terms of total nitrogen (TN) and total phosphorus (TP), is ranked from highest to lowest as follows: animal husbandry, planting industry, and rural life. The non-point source pollution from animal husbandry is predominantly attributed to cattle and sheep, while the planting industry's pollution mainly stems from wheat, corn, and cotton crops. The pollution associated with rural life is largely due to the increasing rural population; (2) The relationship between agricultural non-point source pollution and economic growth in Xinjiang is not only an inverted "U" type but also an inverted "N" type, "U" type, and linear type. This suggests that as the economy grows, the pollution load may initially increase, reach a peak, and then decline, or it may rise continuously or show a linear trend. The findings provide insights into the complex relationship between agricultural non-point source pollution and economic growth, which can inform policy-makers in developing strategies to balance economic development and environmental protection in the region.<strong></strong></p>
Marabar Caves as a Symbol of Native Identity: An Ecocritical Analysis of A Passage to India by E.M. Forster
Authors: Hameed Farrukh , Aslam Amina 
Published: September 2024

The study explores the Marabar Caves as a symbol of native identity under the perspective of Ecocriticism in E. M. Forster’s A Passage to India. The phrase ‘Ecocriticism’ was initially coined by William Rueckert in 1978 in his essay “Literature and Ecology.” It refers to the perspective of examining writers’, researchers’, and poets’ works in the context of the environment and the natural world. Additionally, the research analyzes the Ecocritical elements involved in the Marabar caves’ scenery and incident as portrayed and described in A Passage to India. The Caves prove to be substantial for Aziz and other natives like Mahmoud Ali, while for Mrs. Moore, it proves to be meaningless and absurd. The Caves do not embrace the outsiders/intruders to be part of it. Adela Quested's hostile treatment of Caves is the central evidence of the argument. Moreover, the current study explores the effects of environment and culture on humans. It motivates people to find the affiliation between nature and ourselves. The objective of the study is to understand the influence of a homeland or birthplace on one’s life under the domain of Ecocriticism. Ecocritical elements help to explore the significance of the place in our lives. The echo of the Marabar Caves determines the identity of the natives and distinguishes them from outsiders as separate and independent human beings. It represents the inner anxiety of the oppressed. It further pushes the natives to stand up for their rights and raise their voices against colonial powers. The study is exploratory and interpretive.