bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Office Hour Participation on Student Performance
Authors: Schertzer Michael J. , Robinson Risa , Landschoot Timothy , Ghosh Amitabha , Liberson Alexander , Hensel Edward 
Published: January 2017

Office hours are available for students to receive extra help outside of class. Unfortunately, this resource is often underutilized by students despite efforts to schedule convenient and accessible office hour times. Previous survey results from students attending a variety of courses in Mechanical Engineering at the Rochester Institute of Technology (RIT) have shown a positive correlation between low office hour attendance and the following factors: (i) high understanding of course material, (ii) procrastination and lack of time to seek help before deadlines, and (iii) low time studying materials outside of class. Interestingly, the results of this survey did not support the hypothesis that students who attended more office hours performed better.
A new homework grading policy was instituted in Thermodynamics and Fluid Mechanics I in the fall and spring semesters of the 2013 academic year at RIT. Under this policy, students were required to visit office hours to receive credit for completion of assigned weekly problems. Implementation of this policy has provided quantitative information regarding participation and timing of office hour visits. This investigation will examine the effects of attendance and timing of office hour participation on metrics of performance including final class grades and theoretical understanding as measured by performance on multiple choice test questions.
Results presented here suggest that the office hour grading system resulted in high participation rates across a broad range of students. Higher office hour participation rates had a positive impact on student performance in long answer exam problems and low impact on performance in multiple choice questions. While performance was a stronger function office participation at the of end of term than in week five, early semester participation rates can be used as a tool to help identify students at risk of dropping a class or receiving a poor grade.
Embedding Specialized Online Learning Modules in Courses
Authors: Singh Kumar V. , Khan Fazeel 
Published: January 2017

In recent years, online learning modules and interactive tools have been developed for integrating synergistic computational and experimental activities into several courses in the mechanical and manufacturing engineering curriculum. These modules may complement existing labs, introduce experiments to lecture-based courses, or help reinforce the understanding of concepts within a course through case studies, computational modeling and its validation through experimental data analysis. Within a given undergraduate course in engineering, the traditional approach is to cover the fundamental concepts and their applications in problem solving and design. However, often some advanced concepts pertinent to the course material cannot be included in great details due to the restrictions on total number of credit/teaching hours. The exposure to such advanced material is considered very important for establishing a broader appreciation of the relevance of the course material and potentially instilling an interest in successive classes and, most importantly, research projects.
The project described in this paper has focused in the development of learning modules which can be used in various courses to introduce advanced topics, analyses and applications related to the fundamental course content. In this paper the development, implementation and assessment of two modules which feature enhanced content is presented. One module has been designed to be used as a tutorial on rotor dynamics and has been embedded in an introductory course on mechanical vibrations. The second is a module being developed for introducing the static and dynamic characterization of viscoelastic polymers. This module will be associated with an advanced mechanics of materials course, as well as the course on vibrations. These two separate concepts/topics are not formally a part of the undergraduate level courses but the underlying concepts can be easily related to the associated course learning outcomes. Such modules can, furthermore, be modified and used with various other courses as assignments and/or as a pre-requisite to a given case study. These modules can also be used for training and support of undergraduate researchers.
Inverse Dynamics Modeling of Paralympic Wheelchair Curling
Authors: Laschowski Brock , Mehrabi Naser , McPhee John 
Published: January 2017

Paralympic wheelchair curling is an adapted version of Olympic curling played by individuals with spinal cord injuries, cerebral palsy, multiple sclerosis, and lower extremity amputations. To the best of the authors’ knowledge, there has been no experimental or computational research published regarding the biomechanics of wheelchair curling. Accordingly, the objective of the present research was to quantify the angular joint kinematics and dynamics of a Paralympic wheelchair curler throughout the delivery. The angular joint kinematics of the upper extremity were experimentally measured using an inertial measurement unit system; the translational kinematics of the curling stone were additionally evaluated with optical motion capture. The experimental kinematics were mathematically optimized to satisfy the kinematic constraints of a subject-specific multibody biomechanical model. The optimized kinematics were subsequently used to compute the resultant joint moments via inverse dynamics analysis. The main biomechanical demands throughout the delivery (ie, in terms of both kinematic and dynamic variables) were about the hip and shoulder joints, followed sequentially by the elbow and wrist. The implications of these findings are discussed in relation to wheelchair curling delivery technique, musculoskeletal modeling, and forward dynamic simulations.
Draft Genome Sequence of
Micromonospora
sp. Strain WMMB235, a Marine Ascidian-Associated Bacterium
Authors: Adnani Navid , Braun Doug R. , McDonald Bradon R. , Chevrette Marc G. , Currie Cameron R. , Bugni Tim S. 
Published: January 2017

ABSTRACT

Micromonospora
sp. strain WMMB235 was isolated in 2011 off the coast of the Florida Keys, USA, from a marine ascidian as part of an ongoing drug discovery project. Analysis of the ~7.1-Mb genome provides insight into this strain's biosynthetic potential, means of regulation, and response to coculturing conditions.
Complete Genome Sequence of Mumps Virus Isolated from Karnataka State, India
Authors: Vaidya Sunil R. , Raut Chandrashekhar G. , Chowdhury Deepika T. , Hamde Venkat S. 
Published: January 2017

ABSTRACT
We report the first whole-genome sequence of mumps virus isolated from a two-year-old girl with bilateral parotitis from a Chikkahallivana village in the Davangere district of Karnataka State, India. The genome of the Davangere mumps isolate was 15,384 bp in length and identical to previously published mumps virus (MuV) genomes from India. BLAST results show 99.1% identity with previously sequenced genotype C viruses isolated from the states of Maharashtra, Tamil Nadu, and Uttar Pradesh.
Genome Sequence of Uric Acid-Fermenting Eubacterium angustum DSM 1989
T
(MK-1)
Authors: Poehlein Anja , Galperin Michael Y. , Andreesen Jan R. , Daniel Rolf 
Published: January 2017

ABSTRACT

Eubacterium angustum
DSM 1989
T
(MK-1) is a strictly anaerobic and uric acid-, xanthine-, and guanine-fermenting organism isolated from sewage sludge. The draft genome consists of one circular chromosome (2.4 Mb) and harbors 2,397 predicted protein-encoding genes.
Metagenome Sequencing of Prokaryotic Microbiota Collected from Rivers in the Upper Amazon Basin
Authors: Santos-Júnior Célio Dias , Kishi Luciano Takeshi , Toyama Danyelle , Soares-Costa Andrea , Oliveira Tereza Cristina Souza , de Miranda Fernando Pellon , Henrique-Silva Flávio 
Published: January 2017

ABSTRACT
Tropical freshwater environments, like rivers, are important reservoirs of microbial life. This study employed metagenomic sequencing to survey prokaryotic microbiota in the Solimões, Purus, and Urucu Rivers of the Amazon Basin in Brazil. We report a rich and diverse microbial community.
Whole-Genome Sequence of Escherichia coli Serotype O157:H7 Strain PA20
Authors: Uhlich Gaylen A. , Paoli George C. , Zhang Xinmin , Dudley Edward G. , Figler Hillary M. , Cottrell Bryan J. , Andreozzi Elisa 
Published: January 2017

ABSTRACT

Escherichia coli
serotype O157:H7 strain PA20 is a Pennsylvania Department of Health clinical isolate. It has been used to study biofilm formation in O157:H7 clinical isolates, where the high incidence of prophage insertions in the
mlrA
transcription factor disrupts traditional
csgD
biofilm regulation. Here, we report the complete PA20 genome sequence.
Metaviromes of Extracellular Soil Viruses along a Namib Desert Aridity Gradient
Authors: Zablocki Olivier , Adriaenssens Evelien M. , Frossard Aline , Seely Mary , Ramond Jean-Baptiste , Cowan Don 
Published: January 2017

ABSTRACTThe Namib Desert in southwest Africa is hyperarid and composed of distinct microbial communities affected by a longitudinal aridity gradient. Here, we report four soil metaviromes from the Namib Desert, assessed using deep sequencing of metavirome libraries prepared from DNA extracted from gravel plain surface soils.
Annotation of Fusarium graminearum (PH-1) Version 5.0
Authors: King Robert , Urban Martin , Hammond-Kosack Kim E. 
Published: January 2017

ABSTRACT

Fusarium graminearum
floral infections are a major risk to the global supply of safe cereal grains. We report updates to the PH-1 reference genome and significant improvements to the annotation. Changes include introduction of legacy annotation identifiers, new gene models, secretome and effectorP predictions, and inclusion of extensive untranslated region (UTR) annotations.
Rapidly Growing Mycobacteria
Authors: Brown-Elliott Barbara A. , Philley Julie V. 
Published: January 2017

ABSTRACT

Rapidly growing mycobacteria (RGM) compose approximately one-half of the currently validated mycobacterial species and are divided into six major groups, including the
Mycobacterium fortuitum
group,
M. chelonae/M. abscessus
complex,
M. smegmatis
group,
M. mucogenicum
group,
M. mageritense
/
M. wolinskyi
, and the pigmented RGM. This review discusses each group and highlights the major types of infections associated with each group. Additionally, phenotypic and molecular laboratory identification methods, including gene sequencing, mass spectrometry, and the newly emerging whole-genome sequencing, are detailed, along with a discussion of the current antimicrobial susceptibility methods and patterns of the most common pathogenic species.
Female genital mutilation in children presenting to Australian paediatricians
Authors: Zurynski Yvonne , Phu Amy , Sureshkumar Premala , Cherian Sarah , Deverell Marie , Elliott Elizabeth J 
Published: January 2017

ObjectiveThe WHO reports that female genital mutilation/cutting (FGM/C) is an ancient cultural practice prevalent in many countries. FGM/C has been reported among women resident in Australia. Our paper provides the first description of FGM/C in Australian children.DesignCross-sectional survey conducted in April–June 2014.SettingPaediatricians and other child health specialists recruited through the Australian Paediatric Surveillance Unit were asked to report children aged <18 years with FGM/C seen in the last 5 years, and to provide data for demographics, FGM/C type, complications and referral for each case.ParticipantsOf 1311 eligible paediatricians/child health specialists, 1003 (76.5%) responded.ResultsTwenty-three (2.3%) respondents had seen 59 children with FGM/C and provided detailed data for 31. Most (89.7%) were identified during refugee screening and were born in Africa. Three (10.3%) were born in Australia: two had FGM/C in Australia and one in Indonesia. All parents were born overseas, mainly Africa (98.1%). Ten children had WHO FGM/C type I, five type II, five type III and six type IV. Complications in eight children included recurrent genitourinary infections, menstrual, sexual, fertility and psychological problems. Nineteen children (82.6%) were referred to obstetrics/gynaecology: 16 (69.9%) to social work and 13 (56.5%) to child protection.ConclusionsThis study confirms that FGM/C is seen in paediatric clinical practice within Australia. Paediatricians need cultural awareness, education and resources to help them identify children with FGM/C and/or at risk of FGM/C, to enable appropriate referral and counselling of children, families and communities to assist in the prevention of this practice.
A survey of neurointerventionalists on thrombectomy practices for emergent large vessel occlusions
Authors: Fargen Kyle M , Arthur Adam S , Spiotta Alejandro M , Lena Jonathan , Chaudry Imran , Turner Raymond D , Turk Aquilla S 
Published: January 2017

BackgroundThe effect of the five positive randomized controlled trials on thrombectomy practices and procedural volume has yet to be defined. Further, few studies have attempted to define modern thrombectomy practices in terms of selection criteria and devices used.MethodsA 21 question survey of Society of Neurointerventional Surgery (SNIS) physicians was administered using the SurveyMonkey website, addressing current practices as well as changes from before January 1, 2015 to the months after this date.ResultsA total of 78 responses were obtained (approximately 10% of SNIS membership). Prior to January 2015, two-thirds of respondents reported performing 1–5 thrombectomies per month (67%), with 31% performing more than 5 per month. Following January 2015, 62% of respondents reported performing more than 5 thrombectomies per month; 45% of respondents reported a higher number of thrombectomies after trial publication. 73% and 80% of respondents indicated that inpatient consultations and hospital to hospital transfers for thrombectomy have increased, respectively. A plurality of respondents reported using A Direct Aspiration First Pass Technique (40%) as the first strategy for revascularization. Most commonly, neurointerventionalists reported using conscious sedation (56%) for anesthesia. 74% of respondents indicated being successful with their primary technique in at least 70% of cases.ConclusionsThis survey of predominantly academic SNIS physicians indicates that inpatient consultations, hospital to hospital transfers, and thrombectomy procedural volumes have increased modestly since the publication of the five major stroke trials this year. In addition, many respondents indicated an increase in aggressiveness in pursuing thrombectomy based on selection criteria.
RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers
Authors: Irshad Sheeba , Flores-Borja Fabian , Lawler Katherine , Monypenny James , Evans Rachel , Male Victoria , Gordon Peter , Cheung Anthony , Gazinska Patrycja , Noor Farzana , Wong Felix , Grigoriadis Anita , Fruhwirth Gilbert O. , Barber Paul R. , Woodman Natalie , Patel Dominic , Rodriguez-Justo Manuel , Owen Julie , Martin Stewart G. , Pinder Sarah E. , Gillett Cheryl E. , Poland Simon P. , Ameer-Beg Simon , McCaughan Frank , Carlin Leo M. , Hasan Uzma , Withers David R. , Lane Peter , Vojnovic Borivoj , Quezada Sergio A. , Ellis Paul , Tutt Andrew N.J. , Ng Tony 
Published: January 2017

Abstract
Cancer cells tend to metastasize first to tumor-draining lymph nodes, but the mechanisms mediating cancer cell invasion into the lymphatic vasculature remain little understood. Here, we show that in the human breast tumor microenvironment (TME), the presence of increased numbers of RORγt+ group 3 innate lymphoid cells (ILC3) correlates with an increased likelihood of lymph node metastasis. In a preclinical mouse model of breast cancer, CCL21-mediated recruitment of ILC3 to tumors stimulated the production of the CXCL13 by TME stromal cells, which in turn promoted ILC3–stromal interactions and production of the cancer cell motile factor RANKL. Depleting ILC3 or neutralizing CCL21, CXCL13, or RANKL was sufficient to decrease lymph node metastasis. Our findings establish a role for RORγt+ILC3 in promoting lymphatic metastasis by modulating the local chemokine milieu of cancer cells in the TME. Cancer Res; 77(5); 1083–96. ©2017 AACR.
Mechanisms of Mas1 Receptor-Mediated Signaling in the Vascular Endothelium
Authors: Hoffmann Brian R. , Stodola Timothy J. , Wagner Jordan R. , Didier Daniela N. , Exner Eric C. , Lombard Julian H. , Greene Andrew S. 
Published: January 2017

Objective—
Angiotensin II (AngII) has been shown to regulate angiogenesis and at high pathophysiological doses to cause vasoconstriction through the AngII receptor type 1. Angiotensin 1 to 7 (Ang-(1–7)) acting through the Mas1 receptor can act antagonistically to high pathophysiological levels of AngII by inducing vasodilation, whereas the effects of Ang-(1–7) signaling on angiogenesis are less defined. To complicate the matter, there is growing evidence that a subpressor dose of AngII produces phenotypes similar to Ang-(1–7).

Approach and Results—
This study shows that low-dose Ang-(1–7), acting through the Mas1 receptor, promotes angiogenesis and vasodilation similar to a low, subpressor dose of AngII acting through AngII receptor type 1. In addition, we show through in vitro tube formation that Ang-(1–7) augments the angiogenic response in rat microvascular endothelial cells. Using proteomic and genomic analyses, downstream components of Mas1 receptor signaling were identified, including Rho family of GTPases, phosphatidylinositol 3-kinase, protein kinase D1, mitogen-activated protein kinase, and extracellular signal–related kinase signaling. Further experimental antagonism of extracellular signal–related kinases 1/2 and p38 mitogen-activated protein kinase signaling inhibited endothelial tube formation and vasodilation when stimulated with equimolar, low doses of either AngII or Ang-(1–7).

Conclusions—
These results significantly expand the known Ang-(1–7)/Mas1 receptor signaling pathway and demonstrate an important distinction between the pathological effects of elevated and suppressed AngII compared with the beneficial effects of AngII normalization and Ang-(1–7) administration. The observed convergence of Ang-(1–7)/Mas1 and AngII/AngII receptor type 1 signaling at low ligand concentrations suggests a nuanced regulation in vasculature. These data also reinforce the importance of mitogen-activated protein kinase/extracellular signal–related kinase signaling in maintaining vascular function.
Ventricular Tachycardia Ablation in Severe Heart Failure
Authors: Tzou Wendy S. , Tung Roderick , Frankel David S. , Vaseghi Marmar , Bunch T. Jared , Di Biase Luigi , Tholakanahalli Venkatakrishna N. , Lakkireddy Dhanunjaya , Dickfeld Timm , Saliaris Anastasios , Weiss J. Peter , Mathuria Nilesh , Tedrow Usha , Afzal Mohammed R. , Vergara Pasquale , Nagashima Koichi , Patel Mehul , Nakahara Shiro , Vakil Kairav , Burkhardt J. David , Tseng Chi-Hong , Natale Andrea , Shivkumar Kalyanam , Callans David J. , Stevenson William G. , Della Bella Paolo , Marchlinski Francis E. , Sauer William H. 
Published: January 2017

Background—
Ventricular tachycardia (VT) radiofrequency ablation has been associated with reduced VT recurrence and mortality, although it is typically not considered among New York Heart Association class IV (NYHA IV) heart failure patients. We compared characteristics and VT radiofrequency ablation outcomes of those with and without NYHA IV in the International VT Ablation Center Collaboration.

Methods and Results—

NYHA II–IV patients undergoing VT radiofrequency ablation at 12 international centers were included. Clinical variables, VT recurrence, and mortality were analyzed by NYHA IV status using Kaplan–Meier analysis and Cox proportional hazard models. There were significant differences between NYHA IV (n=111) and NYHA II and III (n=1254) patients: NYHA IV had lower left ventricular ejection fraction; more had diabetes mellitus, kidney disease, cardiac resynchronization implantable cardioverter–defibrillator, and VT storm despite greater antiarrhythmic drug use (
P
<0.01). NYHA IV subjects required more hemodynamic support, were inducible for more and slower VTs, and were less likely to undergo final programmed stimulation. There was no significant difference in acute complications. In-hospital deaths, recurrent VT, and 1-year mortality were higher in the NYHA IV group, in the context of greater baseline comorbidities. Importantly, NYHA IV patients without recurrent VT had similar survival compared with NYHA II and III patients with recurrent VT (68% versus 73%). Early VT recurrence (≤30 days) was significantly associated with mortality, especially in NYHA IV patients.

Conclusions—
Despite greater baseline comorbidities, VT radiofrequency ablation can be safely performed among NYHA IV patients. Early VT recurrence is significantly associated with subsequent mortality regardless of NYHA status. Elimination of recurrent VT in NYHA IV patients may reduce mortality to a level comparable to NYHA II and III with arrhythmia recurrence.
Fraz. zbić z pantałyku ‘stropić kogo, pozbawić pewności siebie’
Authors: Rytter Grażyna 
Published: January 2017

The phrase zbić z pantałyku ‘to perplex, shatter somebody’s confidence’The article concerns the East-­Slavic linguistic influence on Polish in the second half of the nineteenh century as exemplified by the meaning of the phrase zbić z pantałyku. Today’s meaning of the phrase is associated with another phraseologism zbić z tropu ‘to throw [lit. knock] off trace,’ which originates from the hunting jargon. *Pantałyk as a separate word is not (and never has been) used in general Polish, and the comprehensibility of the whole phrase is the result of the sum of its components.East Slavic counterparts of the phrase are attested from the mid­nineteenth century. In the Polish of the period, zbić z pantałyku had a colloquial status, and its usefulness in the sphere of everyday communication was a manifestation of economy of imaginary rather than conceptual means of expression. Especially in the conditions of widespread bilingualism, the new phrase could easily be recognized against the background of contemporary usage of near­synonymous colloquial phrases derived from the verb zbić ‘to beat’ but also ‘to knock off.’The greater frequency of zbić z pantałyku in the Polish of south­eastern borderlands resulted from a combination of factors, mainly the blurred boundaries between literary and dialectal (folk) phraseology. Fraz. zbić z pantałyku ‘stropić kogo, pozbawić pewności siebie’Artykuł dotyczy wpływów ruskojęzycznych w polszczyźnie drugiej połowy XIX wieku. Dziś znaczenie frazeologizmu zbić z pantałyku to odpowiednik wybić z szyku, zbić z tropu, ‘zmieszać, stropić’, realnie ‘pomieszać krok’, ‘stracić ślad (na polowaniu)’.*Pantałyk jako wyraz samodzielny nie jest (i nigdy nie był) używany w polszczyźnie ogólnej, natomiast znaczenie całego frazeologizmu wynika z sumy jego składników.Odpowiedniki wschodniosłowiańskie poświadczone są od połowy XIX stulecia. W ówczesnej polszczyźnie zbić z pantałyku miało status potoczny, którego użyteczność w sferze komunikacji codziennej to przejaw ekonomiczności środków obrazowych zamiast pojęciowych.Nowy frazeologizm mógł być łatwo rozpoznawany w warunkach bilingwizmu językowego na tle ówczesnych środków z tradycją użycia w sferze potocznej. O szczególnej częstotliwości użycia zbić z pantałyku w polszczyźnie kresów południowo­wschodnich zdecydował splot czynników, głównie zaś „rozmyte” granice między frazeologią literacką a gwarową (ludową).