bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pewss: A platform of extensible workflow simulation service for workflow scheduling research
Authors: Tsai Meng‐Han , Lai Kuan‐Chou , Chang Hsi‐Ya , Chen Kuan Fu , Huang Kuo‐Chan 
Published: December 2017

SummaryThis paper presents a Platform of Extensible Workflow Simulation Service (Pewss), which we have developed to provide a cloud service for aiding research work in workflow scheduling. The simulation has been a major tool for performance evaluation and comparison in workflow scheduling research. However, researchers usually have to develop their own simulation programs with limited functionality, simply outputting summarized performance results. Pewss has been developed for easing and improving current practices in conducting performance simulations during studying of existing workflow scheduling algorithms or designing of new scheduling algorithms. Pewss has been designed based on the Software as a Service (SaaS) model, adopting a multiuser Web‐based client/server architecture. Conducting simulation experiments on Pewss, researchers simply have to implement the scheduling algorithm under study instead of a whole simulation environment, allowing them to focus on their research work without spending unnecessary efforts on the simulation implementation details. Pewss provides the visualization of a workflow execution schedule based on simulation results, offering a convenient way for researchers to gain an insight into the effectiveness, characteristics, and performance bottleneck of scheduling algorithms. As a multiuser environment, Pewss also provides functionality for researchers to facilitate comparative performance analysis and collaborative research works effectively. Pewss has been used in our research work on task‐parallel workflow scheduling and has been planned to be extended to support other types of workflow scheduling research problems, eg, mixed‐parallel workflows.
Key requirements in the procurement of future low observable combat vehicles: a European perspective
Authors: Andersson Kent E. 
Published: December 2017

AbstractThe aim of this study is to propose guidelines for the systems engineering of future stealth combat vehicles using Low Observable Technology (LOT). A case study approach, based on interviews and document reviews, was used to analyze the systems engineering processes of the SEP multirole armored vehicle and the Visby class corvette respectively. The result is a thorough investigation of what worked in the cases studied, but with lessons extrapolated into recommendations for future development programs. These will have to deal with an increasingly complex sensor threat and a transformed, multilateral, European procurement environment. The main conclusion is that coherence and traceability between military needs on the battlefield and signature requirements is expected to be particularly challenging. A workflow tailored for requirements analysis in LO combat vehicle programs has, therefore, been derived and is presented here. In addition, the most important enablers for future multilateral development programs involving LOT have been identified as: establishing common best practices, demonstrator programs, an integrated product team approach, and, in line with similar work on combat aircraft, establishing stealth as a key architectural principle.
Identification and characterization of novel promoters for recombinant protein production in yeast Pichia pastoris
Authors: Xu Ning , Zhu Jinxiang , Zhu Qiaoyun , Xing Yanzi , Cai Menghao , Jiang Tianyi , Zhou Mian , Zhang Yuanxing 
Published: December 2017

AbstractPichia pastoris expression system has been widely used in recombinant protein production. So far the majority of heterologous proteins are expressed by methanol inducible promoter PAOX1 and constitutive promoter PGAP. The use of other promoters is rather limited. Here we selected 16 potentially efficient and regulatory promoter candidates based on the RNA‐seq and RNA folding free energy ΔG data. GFP and recombinant amylase were inserted after these promoters to reveal their strength and efficiency under different carbon sources and culture scales. Two novel promoters were successfully identified and could possibly be applied in recombinant protein expression: the methanol‐inducible promoter P0547 and the constitutive promoter P0472.
Recovery of Voice After Reconstruction of the Recurrent Laryngeal Nerve and Adjuvant Nimodipine
Authors: Mattsson P. , Frostell A. , Björck G. , Persson J. K. E. , Hakim R. , Zedenius J. , Svensson M. 
Published: December 2017

AbstractBackgroundTransection injury to the recurrent laryngeal nerve (RLN) has been associated with permanent vocal fold palsy, and treatment has been limited to voice therapy or local treatment of vocal folds. Microsurgical repair has been reported to induce a better function. The calcium channel antagonist nimodipine improves functional recovery after experimental nerve injury and also after cranial nerve injury in patients. This study aims to present voice outcome in patients who underwent repair of the RLN and received nimodipine during regeneration.MethodsFrom 2002–2016, 19 patients were admitted to our center with complete unilateral injury to the RLN and underwent microsurgical repair of the RLN. After nerve repair, patients received nimodipine for 2–3 months. Laryngoscopy was performed repeatedly up to 14 months postoperatively. The Voice Handicap Index (VHI) was administered, and patients’ maximum phonation time (MPT) was recorded during the follow‐up.ResultsAll patients recovered well after surgery, and nimodipine was well tolerated with no dropouts. None of the patients suffered from atrophy of the vocal fold, and some patients even showed a small ab/adduction of the vocal fold on the repaired side with laryngoscopy. During long‐term follow‐up (>3 years), VHI and MPT normalized, indicating a nearly complete recovery from unilateral RLN injury.ConclusionsIn this cohort study, we report the results of the first 19 consecutive cases at our center subjected to reconstruction of the RLN and adjuvant nimodipine treatment. The outcome of the current strategy is encouraging and should be considered after iatrogenic RLN transection injuries.
Changes in Clinical Practice Reduce the Rate of Anastomotic Leakage After Colorectal Resections
Authors: Iversen Henrik , Ahlberg Madelene , Lindqvist Marja , Buchli Christian 
Published: December 2017

AbstractBackgroundAnastomotic leakage is a serious clinical problem after colorectal resections and is associated with a significantly increased length of stay, morbidity and mortality. The aim of the present study was to evaluate the effect of changes in clinical practice on anastomotic leakage rate after colorectal resections.MethodsRetrospective cohort study based on prospectively collected data. All 894 patients with primary anastomosis after colorectal resection at a tertiary referral center between 2006 and 2013 were analyzed. Changes in clinical practice aiming at reducing the rate of anastomotic leakages were introduced in January 2010 and were characterized by exclusion of perioperative nonsteroidal anti‐inflammatory drugs, introduction of intra‐operative goal‐directed fluid therapy and avoidance of primary anastomoses in emergency resections. The study population was divided into two groups, one treated before and one after the introduction of changes in clinical practice. Groups were compared regarding patient characteristics and incidence of anastomotic leakage.ResultsThe cumulative incidence of anastomotic leakage after colorectal resections decreased from 10.0% (41 of 409) to 4.5% (22 of 485) after changing clinical practice, relative risk 0.45 (95% CI 0.27–0.75,p= 0.002). The adjusted odds ratio was 0.45 (0.26–0.78,p= 0.004). A separate analysis showed a decrease after colon resections from 9.1% (23 of 252) to 4.5% (14 of 310), relative risk 0.49 (0.26–0.94,p= 0.039), and from 11.5% (18 of 157) to 4.6% (8 of 175) after rectal resections, relative risk 0.40 (0.18–0.89,p= 0.024).ConclusionImplementing a structured change of clinical practice can significantly reduce the anastomotic leakage rate after colorectal resections.Trial registrationClinical trial registration number: ACTRN12617001497392.
A Nomogram to Predict Prognosis in Malignant Pleural Mesothelioma
Authors: Wang Shuai , Ma Ke , Chen Zongwei , Yang Xiaodong , Sun Fenghao , Jin Yulin , Shi Yu , Jiang Wei , Wang Qun , Zhan Cheng 
Published: December 2017

AbstractBackgroundMalignant pleural mesothelioma (MPM) is a rare malignancy with heterogeneous outcomes. This study was aimed to develop a nomogram to precisely and visually predict survival of MPM patients.MethodsData from Surveillance, Epidemiology, and End Results database (1973–2014) on MPM were screened and retrieved. The prognostic effects of variables, including age, sex, race, year of diagnosis, laterality, histology, tumor stage, surgery, chemotherapy, and radiotherapy were analyzed using Kaplan–Meier method and Cox proportional hazard model. A nomogram was formulated to predict overall survival of MPM patients.ResultsA total of 1092 cases who met inclusion criteria were included in this study. The overall 1‐, 2‐, and 3‐year survival rate in the entire cohort was 45.1, 23.0, and 12.1%, with median survival of 11 months. Cox regression analysis showed that age (P < 0.001), race (P = 0.003), histology type (P < 0.001), T stage (P < 0.001), M stage (P < 0.001), TNM stage (P < 0.001), cancer‐directed surgery (P < 0.001), and chemotherapy (P < 0.001) were all independent prognostic factors of MPM patients. A nomogram was established based on the results of multivariate analysis. The internal bootstrap resampling approach suggested the nomogram had sufficient discriminatory power with the C‐index of 0.705 (95% CI 0.681–0.729). The calibration plots also demonstrated good consistence between the prediction and the observation.ConclusionsWe developed a nomogram to accurately predict clinical outcomes of MPM patients based on individual characteristics. Risk stratification by the survival nomogram could optimize individual therapies and follow‐up.
Insights into portability issues of FM3TR waveform
Authors: Le Roy Frédéric , Rakotondrainibe Lahatra , Delahaye Jean-Philippe , Mansour Ali 
Published: December 2017

AbstractThis manuscript focuses on issues related to the implementation of the Future Multiband Multiwaveform Modular Tactical Radio (FM3TR) waveform on two different SCA platforms with similar hardware but different SCA development and deployment environments. Our experimental results showed that a SCA standardization based on technologies such as CORBA, XML, IDL, is not enough to ensure the portability of the waveform. Indeed, the files generated by SCA 2.2.2 environments (ZCE, SCA Architect, http://nordiasoft.com/products/scari-software-suite/sca-architect/) may often use a specific non-standard IDL interface to generate software components. To corroborate our statement, specific examples of SCA components are considered. The portability of the waveform depends on the waveform software used by the porting team. Three classic cases can be observed during the development of a waveform according to a standard specification: The first case is related to waveform development from scratch, the second case is observed when a static library is used to carry the golden code of the waveform and the third one occurs when only platform specific codes are available to the porting process. Finally, a general discussion about portability is provided.
Physicians’ Awareness and Utilization of Genetic Services in Texas
Authors: Diamonstein Callie , Stevens Blair , Shahrukh Hashmi S. , Refuerzo Jerrie , Sullivan Cathy , Hoskovec Jennifer 
Published: December 2017

AbstractThe number of disorders for which genetic testing is available has increased nearly 500% in the past 15 years. Access to genetic tests and services often hinges on physicians’ ability to identify patients at risk for genetic disease and provide appropriate testing and counseling or refer to genetic specialists. Recent research demonstrates the need for referrals to genetic specialists by showing that many physicians lack skills required to perform appropriate genetic services, such as making proper risk assessments, providing genetic counseling, ordering genetic testing and interpreting results. However, little research exists on physicians’ awareness and utilization of genetic services. In this study, an electronic survey evaluating practicing physicians’ awareness of, utilization of and perceived barriers to genetic services in Texas, and interest in learning more about genetics and genetic services was distributed via state physician organizations. Of the 157 participants, approximately half reported they were moderately or very aware of genetic testing and services in their area. Very few reported awareness of telemedicine services. Over two‐thirds reported never or rarely referring to genetic counselors or other genetic specialists, despite 75% reporting they had noticed an increased impact of genetics on their field and 61% reporting they had discussed genetics more in their day‐to‐day practice in the last 5–10 years. Only 20% reported genetics was very integral to their specialty. Over three‐fourths of all participants indicated interest in learning more about genetics, genetic testing, and genetic services. Among the most frequently chosen barriers to genetic counselors were awareness‐related barriers such as not knowing how to refer to a genetic counselor. Responses to many items varied significantly by medical specialty. The results identify a need to increase awareness of genetic services and referral logistics. Specific findings can help direct outreach efforts to educate clinicians, such as developing clinically meaningful, specialty‐specific educational objectives.
Firefighters Have a Higher Incidence of Trochlear Chondral Lesions than the Normal Population
Authors: Brady Jacqueline M. , Brown Haydée C. , Nguyen Joseph T. , Smith Halley , Mannor Dana A. , Kelly Anne M. , Hannafin Jo A. 
Published: December 2017

Background Firefighters’ knees are subjected to significant dynamic and static forces, resulting in increased knee complaints and a higher relative risk of osteoarthrosis, compared with aged-matched office workers. Firefighters wear or carry a total of 80 to 100 lbs. of gear while performing intensive physical activity. Purpose/Question The purpose of this study was to determine whether a central femoral trochlear lesion was observed in firefighters undergoing knee arthroscopy for other diagnoses. Methods A retrospective chart review of 159 knees in 146 firefighters undergoing arthroscopy for treatment of acute meniscal injury or anterior cruciate ligament reconstruction over a 14-year period was undertaken. Patient demographics, physical examination results, trochlear lesion size and grade, and firehouse type (engine vs. ladder company) and firefighter position (seniority) were recorded. Comparisons of characteristics in those with and without trochlear lesions were performed. Results The average patient age was 42.2 years (range, 27 to 64 years). Ninety-eight knees (62%) had trochlear lesions and 33 knees (51%) had matching patellar lesions. Patients with lesions were older (43.2 vs. 40.5 years). Mean trochlear lesion size was 19.5 ± 13.7 mm by 18.9 ± 12.4 mm. Lesion grade distribution was grade 1 or 2 in 24 knees (24%) and grade 3 or 4 in 67 knees (44%). Trochlear lesion presence was associated with a body mass index of over 30. Current engine company members had more advanced lesions. Conclusions A “firefighter's trochlea” was present in the majority of firefighters undergoing knee arthroscopy. Higher age and longer tenure as a firefighter prior to surgery were associated with more advanced lesions. Firefighters working in engine companies at the time of arthroscopy were at a greater risk of developing low-grade lesions but not high-grade lesions. Firefighters move between ladder and engine companies, thus a definitive association with company type cannot be reached in this retrospective study. This lesion may reflect the increase in patellofemoral biomechanical stresses secondary to the physical demands of the occupation.
Living Shorelines Support Nearshore Benthic Communities in Upper and Lower Chesapeake Bay
Authors: Davenport Theresa M. , Seitz Rochelle D. , Knick Kathleen E. , Jackson Nina 
Published: December 2017

Abstract
Human population growth and sea-level rise are increasing the demand for protection of coastal property against shoreline erosion. Living shorelines are designed to provide shoreline protection and are constructed or reinforced using natural elements. While living shorelines are gaining popularity with homeowners, their ability to provide ecological services (e.g., habitat provision and trophic transfer) is not well understood, and information is needed to improve coastal and resource management decision-making. We examined benthic community responses to living shorelines in two case-study subestuaries of Chesapeake Bay using a before-after control-impact study design. At Windy Hill, a bulkhead was removed and replaced by three tombolos, sand fill, and native marsh vegetation. At Lynnhaven, 25 m of eroding marsh shoreline was stabilized with coir logs, sand fill, and native marsh vegetation. Communities of large (> 3 mm) infauna adjacent to living shorelines at both locations tended to increase in biomass by the end of the study period. Community compositions changed significantly following living shoreline construction at Windy Hill, reflecting a trend toward higher density and biomass of large bivalves at living shorelines compared to pre-construction. Increasing trends in density and biomass of clams and simultaneously decreasing density and decreasing trends in biomass of polychaetes suggest a transition toward stable infaunal communities at living shorelines over time, though longer-term studies are warranted.
Changes in rejection sensitivity across adolescence and emerging adulthood: Associations with relationship involvement, quality, and coping
Authors: Norona Jerika C. , Tregubenko Valerya , Boiangiu Shira Bezalel , Levy Gil , Scharf Miri , Welsh Deborah P. , Shulman Shmuel 
Published: December 2017

ABSTRACTUsing a sample of 110 Israeli youth (72% female), the present study investigates associations between initial levels of rejection sensitivity as well as changes in rejection sensitivity from age 16 to age 23 and relationship involvement, quality, and (growth following) coping with relationship stress. Results showed that rejection sensitivity generally decreased over time into the transition to adulthood. Furthermore, levels of rejection sensitivity at age 16 predicted whether young people were romantically involved by age 23, as well as the quality of their relationships. Yet, the change in level of rejection sensitivity over time explained far more the quality of later romantic relationships and competence in coping with relationship stress than the initial level of rejection sensitivity. These findings have important implications for examining the role of changes in personality attributes such as rejection sensitivity in the transition from adolescence to adulthood.
New methodologies for old problems: tridimensional gastrointestinal organoids and guts-on-a-chip
Authors: Sakalem Marna Eliana , Ribeiro-Paes João Tadeu 
Published: December 2017

Abstract
Objectives The present review intended to present a critical overview of the methodological and experimental advances concerning tridimensional cell culture models within the scope of gastrointestinal research.
Methods A literature review was performed and some of the main published articles in the area were mentioned.
Main results Classic studies and high impact results were presented, starting from the pioneer works with gastrointestinal organoids, with a small gut organoid, to the achievement of guts-on-a-chip and multi-organ-chips. It was also discussed which implications the construction of such co-cultures bring, as well as future applications arising from these new methodologies.
Conclusions Despite the still discrete number of publications, in quantitative terms, there are qualitative promising and consistent results addressing physiopathological aspects and new therapeutic perspectives of tridimensional in vitro cultures in the gastroenterology field. It is expected, thus, that such new methodological approaches, including organoids and guts-on-a-chip, may contribute decisively to the advance in knowledge on basic aspects, as well as on the translation to new therapeutic approaches in gastrointestinal diseases.
Association of sociodemographic and clinical factors with self-image, self-esteem and locus of health control in patients with an intestinal stoma
Authors: Lima Joelma Alves de , Muniz Karina de Cássia , Salomé Geraldo Magela , Ferreira Lydia Masako 
Published: December 2017

Abstract
Objective To evaluate the sociodemographic and clinical factors related to patients with an intestinal stoma and to correlate them with locus of health control, self-esteem and self-image.
Method 44 patients with an intestinal stoma participated in the study. The following instruments were used: Scale for Locus of Health Control, Rosenberg Self-Esteem Scale/UNIFESP-EPM and Body Investment Scale.
Results With regard to Locus Health Control variables, sociodemographic variables with alterations were: unemployed (28.13); retirees (27.79); age up to 50 years (28.44); and singles (27.89). Regarding Body Investment Scale, the sociodemographic variables with alterations were: age up to 50 years (21.79); single (19.15) or married (17.53); retired (18.79) or unemployed (19.83); and can read and write (20.13). Regarding Rosenberg-EPM Self-esteem Scale, all sociodemographic variables were altered.
Conclusions Ostomized patients presented alterations in the following variables: unemployed, retired, aged up to 50 years and unmarried. There were also alterations in individuals whose cause of the stoma was neoplasia, a temporary stoma, stoma time <4 years, and ostomized non-participants of an association or support group, and who also did not practice physical activities. We conclude from these findings that ostomized individuals who participated in the study and who were included in these variables showed negative feelings about their body and believed that only they could control their health and that the people involved in their care and rehabilitation did not could contribute to their improvement.
Health Care Coalitions as Response Organizations: Houston After Hurricane Harvey
Authors: Upton Lori , Kirsch Thomas D. , Harvey Melissa , Hanfling Dan 
Published: December 2017

AbstractHealth care coalitions play an increasingly important role in both preparedness for, response to, and recovery from large scale disaster events occurring across the United States. The actions taken by the South East Texas Regional Advisory Council (SETRAC) in response to the landfall of Hurricane Harvey, and the consequential flooding that ensued, serve as an excellent example of how health care coalitions are increasingly needed to play a unifying role in response. This paper highlights a number of the strategic planning, operational planning and response, information sharing, and resource coordination and management activities that were undertaken for the response to Hurricane Harvey. The successful response to this devastating storm in the Houston, Texas area serves as an example to other regions across the country as they work to implement the 2017-2022 health care capabilities articulated by the Department of Health and Human Services Office of the Assistant Secretary for Preparedness and Response. (Disaster Med Public Health Preparedness. 2017;11:637–639)