bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of selenium in the pathophysiology of cardiorenal anaemia syndrome
Authors: Arai Shigeyuki , Yasukawa Minoru , Shibata Shigeru 
Published: September 2024

AbstractChronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)]. Several lines of evidence indicate that CRAS confers a worse prognosis, suggesting the need to clarify the underlying pathophysiology. Among the micronutrients (trace elements) that are essential to humans, inadequate iron status has previously been implicated in the pathogenesis of CRAS; however, the roles of other trace elements remain unclear. Selenium critically regulates the function of selenoproteins, in which selenocysteine is present at the active centres. The human genome encodes 25 selenoproteins, and accumulating data indicate that they regulate diverse physiological processes, including cellular redox homeostasis, calcium flux, thyroid hormone activity and haematopoiesis, all of which directly or indirectly influence cardiac function. The essential role of selenium in human health is underscored by the fact that its deficiency results in multiple disorders, among which are cardiomyopathy and abnormal erythrocyte morphology. Studies have shown that selenium deficiency is not uncommon in CKD patients with poor nutritional status, suggesting that it may be an under‐recognized cause of anaemia and cardiovascular disorders in these patients. In this review, we discuss the role of selenium in the pathophysiology of CKD, particularly in the context of the interconnection among CKD, cardiac dysfunction and anaemia. Given that selenium deficiency is associated with treatment‐resistant anaemia and an increased risk of CVD, its role as a key modulator of CRAS merits future investigation.
Clinical implication of sarcopenia in patients with acute decompensated heart failure: Design and rationale
Authors: Bai Bingqing , Li Dujuan , Xu Mingyu , Liao Yingxue , Zhou Haofeng , Liu Fengyao , Li Wen , Ma Huan 
Published: September 2024

AbstractBackgroundSarcopenia is widely recognized as an age‐related syndrome that involves a progressive loss of skeletal muscle mass and muscle strength. Many studies have shown that sarcopenia is associated with disease severity and exercise intolerance, as well as an independent predictor of mortality in patients with chronic heart failure. However, there is little research on the impact of sarcopenia on patients hospitalized with acute decompensated heart failure (ADHF).MethodsThis is a prospective, multicentre, observational cohort study. Enrolment of at least 500 participants adults aged over 18 years hospitalized for ADHF is planned, with a minimum of 195 cases each for patients with and without sarcopenia. Each patient is followed up for 6 months, 1 year, 2 years or until the occurrence of endpoint. The primary clinical outcome is all‐cause mortality at 6 months. Other clinical outcomes of interest include cardiovascular mortality, all‐cause hospitalization, heart failure hospitalization and survival time from enrolment to event occurrence. The sympathetic nervous activity, psychosocial factors, quality of life, physical function, and physical activity will be assessed and recorded at baseline. This study will examine the correlation between sarcopenia and prognosis in different subgroups of patients, and explore the additive effect of different comorbidities and sarcopenia on prognosis in patients with ADHF.ConclusionsThis study will provide important information and evidence on the clinical aspects of sarcopenia in patients with ADHF, potentially contributing to accurate risk stratification and optimal clinical management for patients with ADHF.REGISTRATION: (URL: https://www.clinicaltrials.gov); Unique identifier: NCT06298825.
Recovery and characterization of cellulose microfibers from fallen leaves and evaluation of their potential as reinforcement agents for production of new biodegradable packaging materials
Authors: Celik Sudenur , Kutlu Gozde , Tornuk Fatih 
Published: September 2024

AbstractIn the present work, cellulose microfibers (CMFs) isolated from fallen autumn leaves of cherry plum (Prunus cerasifera pissardii nigra), white mulberry (Morus alba) and plane (Platanus orientalis) trees were characterized and used as reinforcement agents in sodium alginate‐based biodegradable films. Fourier transform infrared spectroscopy (FT‐IR) characterization showed that the CMFs were successfully isolated from the leaves with high purity. The extracted CMFs had a particle size ranging from 321.20 nm to 632.26 nm and negative zeta potential values (−27.33 to −21.40). The extraction yield of CMFs ranged from 19.53% to 26.00%. Incorporation of the leaf‐derived CMFs into sodium alginate based films (1%, w:w) increased their tensile strength (from 153.73 to 187.78 MPa) and elongation at break values (from 105.97% to 89.90%) and significantly decreased oxygen (from 121.46 to 75.56 meq kg‐1) and water vapor permeabilities (from 2.36 to 1.60 g mm h−1 m−2 kPa−1)(p < 0.05). Furthermore, the supplementation of CMFs into the biopolymer matrix had no significant effect on the color (L*: 85.35–85.67; a*: −0.75‐0.71; b*: 4.23–4.94) and moisture content (44.64–48.42%) of the film samples, although the thickness increased (40.33–94.66 μm). Scanning electron microscopy (SEM) images showed that CMFs were homogeneously dispersed in the film matrix. Overall, this study confirms that fallen cherry plum, white mulberry, and plane leaves are valuable sources of CMFs which could be used in the manufacturing of biodegradable nanocomposite films as reinforcement agents.
Development and Characterization of a Novel Composite Hydrogel Biomaterial for Improved Mucoperiosteal Wound Repair
Authors: Wang Q. , Dunnwald M. , Kacmarynski D. S. F. , Worthington K. S. 
Published: September 2024

ABSTRACTMucoperiosteal wound healing, as it occurs after pediatric cleft palate surgery, can be challenging due to the limitations of current treatments such as tissue flaps secured with sutures and fibrin glue. In this study, we characterized the in vitro performance of a novel composite hydrogel biomaterial designed to be employed as an in situ wound filler and enhance mucoperiosteal wound healing. We evaluated a range of photopolymerizable formulations containing methacrylated gelatin (GelMA), glycol chitosan, and bioglass microparticles. Our aim was to identify one or more formulations with an appropriate balance of properties against a set of functional requirements that we established for this application. To test the formulations against these criteria, we measured photopolymerization kinetics, mechanical properties, degradation rate, in vitro biocompatibility, and ex vivo tissue adhesion. All formulations polymerized in less than 90 s using violet light. In addition, we found that GelMA‐based hydrogels were more adhesive to mucoperiosteal tissue than clinical standard fibrin glue. Inclusion of small amounts of bioglass in the formulation increased mechanical compatibility with mucoperiosteal tissue, enhanced cytoconductivity, and promoted cell proliferation. Taken together, our results support the suitability of these photopolymerized composite hydrogels as in situ mucoperiosteal wound fillers. Overall, this study lays the groundwork for investigating the in vivo, pre‐clinical effectiveness of these composite hydrogels in improving mucoperiosteal wound healing outcomes.
Crystal structure of the Michaelis complex of trypsin with N‐α‐benzoyl‐l‐arginine ethyl ester
Authors: Akbar Zeeshan , Ahmad Malik Shoaib 
Published: September 2024

AbstractThe crystal structure of Michaelis complex of the bovine trypsin with N‐α‐benzoyl‐l‐arginine ethyl ester (BAEE) was determined at 2.30 Å resolution. The structure of enzyme‐substrate complex was solved in space group H32. The active site of trypsin was found to be occupied with the N‐α‐benzoyl‐l‐arginine ethyl ester. The hydrolyzed product of substrate molecules was also crystallized with trypsin. The substrate was embedded within the S1 binding site of the enzyme, and showed contacts with Gly‐195, Ser‐216, and Ser‐192. Some water molecules were also found within the vicinity of catalytic residues of enzyme. Interestingly, the hydrolyzed product present within the crystal lattice was found to be with inverted configuration. The crystal structure of trypsin in‐complex with N‐α‐benzoyl‐l‐arginine ethyl ester has never been reported previously.
Is a two‐hour monitoring period sufficient and safe for patients undergoing ultrasound‐guided percutaneous liver mass biopsy?: A prospective and multicenter experience
Authors: Aslan Halil Serdar , Arslan Muhammet , Alver Kadir Han , Demirci Mahmut , Korkmaz Mehmet , Esen Kaan , Turmak Mehmet , Deniz Muhammed Akif , Tekinhatun Muhammed , Kisbet Tanju , Arıbal Serkan , Önder Hakan , Ozdemir Mustafa , Ozturk Mehmet Halil , Urfalı Furkan Erturk 
Published: September 2024

AbstractPurposeTo investigate whether patients undergoing percutaneous liver mass biopsy (PLMB) can be safely discharged following a two‐hour monitoring period.MethodsA multi‐center prospective analysis was conducted for 375 patients (196 males and 179 females), mean age 63 ± 12.45 years (range 37–89) who underwent PLMB between August 2023 and March 2024. Patients were monitored for 24 h, and complications were classified as minor or major. The timing of complications was categorized into three groups: within the first two hours, between the 2nd and 24th hours, and within 1 week after 24 hours.ResultsMinor complications occurred in 18.93% (71/375) and major complications in 2.13% (8/375). Most minor complications (80.2%, 57/71) appeared within the first two hours, 12.7% (9/71) between 2 and 24 h, and 7.1% (5/71) after 24 h. All major complications (62.5%, 5/8) except late‐onset cases, occurred within the first two hours. No major complications occurred between 2 and 24 h. Late‐onset major complications occurred in 37.5% (3/8) after 24 h.ConclusionThe two‐hour monitoring period did not adversely impact patient management regarding minor complications and is safe for identifying all major complications except for late‐onset ones. Extending the post‐biopsy recovery period does not significantly improve patient care.
Community‐led transformation principles: Transforming public health learning systems by centering authentic collaboration with community‐based organizations
Authors: Meigs Reba , Sheik Mohamed Amina , Bearse Adriana , Vicente Sarah , Dang Nghi , Deiranieh Asmaa , Zubaidi Reem , Nash Valerie , Ali Maliha , Childers Trenita , Wahdatyar Mohammad , Treichler Emily , Meléndrez Blanca 
Published: September 2024

AbstractIntroductionIn the face of evolving public health challenges, including emerging diseases, pervasive health disparities, and escalating environmental threats, the integration of learning health system (LHS) principles emerges as a vital strategy for enhancing the adaptability and efficacy of public health initiatives. Traditional approaches within these systems often overlook the potential to deeply involve community‐based organizations (CBO) that are led and staffed by the communities they serve as equal and essential partners in the public health discourse.MethodsThis commentary proposes a suite of nine community‐led transformation (CLT) principles aimed at reimagining LHS frameworks to authentically incorporate CBOs at their core. Drawing on the experiences from initiatives supporting Afghan refugees, we illustrate the application of these principles through two detailed case studies.ResultsThese examples demonstrate the CLT principles in action and spotlight the enhanced cultural competency, effectiveness, and equitable power distribution that arise from such partnerships. Centering small to mid‐sized CBOs including ethnic‐led and/or faith based within LHS structures enables the system to access invaluable cultural insights, strengthen community bonds, and empower those communities to spearhead their transformative journey toward sustainable health, equity, and well‐being improvements.ConclusionThe CLT principles herald a shift toward a more inclusive and co‐led public health paradigm by offering a blueprint for stakeholders eager to forge strong, trust‐based coalitions and cocreate initiatives with community leaders including Black, Indigenous, and People of Color (BIPOC) leaders from ethnic‐led and/or faith‐based CBOs. By embracing these principles, public health systems can evolve into truly inclusive, responsive, and sustainable entities poised to advance health equity for all community members.
PETER DRUCKER: MORE RELEVANT THAN EVER FOR TODAY’S LEADERS
Authors: Linkletter Karen E. 
Published: September 2024

AbstractThe author, Research Director of the Management as a Liberal Art Research Institute, has studied directly under Peter Drucker and has written books about him. In assessing Drucker’s work and legacy in a context for today’s leaders, she notes that he “was shaped by the disruptions of World War I, the rise of Nazi Germany, the Great Depression, World War II, and the growth of the United States as a post‐war industrial powerhouse. Given the degree of uncertainty he experienced in the first 35 years of his life, it is not surprising that Drucker sought a path to navigate the rough waters of instability and change.” Regarding his personal/career longevity, “his devotion to lifelong learning and his genuine interest in the lives of so many people helped him produce timely and important work well into his eighties and nineties.” She further discusses Drucker’s work as a social theorist, in management as a human activity, evolving views on leadership, the knowledge society, innovation, the public sector, technology, and the future. Regarding the latter, “decisions regarding advancement must be made with an eye on social costs and benefits, the limitations of technological innovations, and the historical, social, and cultural context of technological innovation.”
Quality of Life after Deep Brain Stimulation in Parkinson's Disease: Does the Target Matter?
Authors: Murcia Carretero Sandra , Petermann Katrin , Debove Ines , Amstutz Deborah , Sousa Mário , Waskönig Julia , Diamantaras Andreas Antonios , Tinkhauser Gerd , Nowacki Andreas , Pollo Claudio , Schuepbach Michael , Krack Paul , Lachenmayer Martin Lenard 
Published: September 2024

AbstractBackgroundDeep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) is an accepted therapy for Parkinson's disease (PD) with disabling motor complications. For elderly patients with poorer cognition and postural instability, GPi has been proposed as the preferable DBS target based on expert opinion, arguing GPi‐DBS may be less complicated by depression, apathy, worsened verbal fluency, and executive dysfunction, resulting in greater improvement in quality of life (QoL). However, data supporting such patient‐tailored approach are lacking.ObjectivesThe aims were to analyze whether the DBS target influences QoL in a PD cohort and a matched subgroup of frail patients with poor cognitive status and reduced postural stability, and whether other factors affect the QoL outcomes.MethodsIn this retrospective study, we analyzed a single‐center cohort of 138 PD patients who received bilateral STN‐DBS (117) or GPi‐DBS (21) using the mentioned approach for target selection. All patients underwent standardized clinical evaluations of motor‐ and nonmotor signs as well as QoL before and 1 year after surgery.ResultsDBS of both targets improved motor signs, dyskinesias, and pain. QoL improved without significant difference between the targets, but with a trend for greater improvement across all QoL domains in favor of the STN, even in an STN subgroup matched to the GPi group.ConclusionOur results contradict the prevailing belief that GPi‐DBS is superior in frail PD patients with cognitive decline and postural instability, questioning the proposed patient‐tailored approach of DBS target selection. Further studies are needed for a data‐driven approach.
High‐resolution incoherent interference imaging without phase measurement
Authors: Yao Mulin , Liu Shengjie , Li Junwei , Li Min , Wang Shengqian , Wei Kai , Cui Hao 
Published: September 2024

AbstractAiming for long‐distance, high‐resolution, passive imaging, we use fiber coupling to replace the spatial coupling of the segmented planar imaging detector for electro‐optical reconnaissance imaging system and propose a novel incoherent interference imaging method, which avoids the problem that the resolution of the imaging system is limited by the size of the silicon wafer. The method uses a phase retrieval algorithm and does not need to measure the phase in the system, effectively avoiding the intrinsic jitter problem of fiber optics. The feasibility of the method in achieving target image reconstruction was verified through simulation; furthermore, an indoor two‐dimensional discrete sampling imaging experiment for a simple four‐rod target was conducted, and an outdoor one‐dimensional feature identification experiment for a two‐rod target was also performed. The results showed that the resolution exceeds the diffraction limit and the reconstruction error of target size is less than 3.5%.
Design and application of D‐band bandpass filter based on 0.18 μm complementary metal oxide semiconductor process
Authors: Chung Ming‐An , Lin Chia‐Wei , Yang Chih‐Wei , Meiy Ing‐Peng 
Published: September 2024

AbstractThis paper designs a bandpass filter for D‐band and 0.18 μm complementary metal oxide semiconductor (CMOS) process. The bandpass filter is composed of an inverted L‐shaped coupling microstrip line and a cross‐coupled resonator, and is coupled to produce two controlled transmission zeros. A defected ground structure is used to make a good impedance match. The designed filter has a 3 dB impedance bandwidth of 52 GHz (149–201 GHz) with a center frequency of 175 GHz and an insertion loss of 3.23 dB. The design of this paper is a CMOS 0.18 μm process capable of applying the D‐band bandpass filter with the advantages of lower insertion loss, broadband, and compact size.
Recent Developments in Sustainable Bio‐Based Wax Nanoemulsions as Edible Coatings for Food Commodities: A Comprehensive Review
Authors: Islam Rayees Ul , Khan Tariq , Junaid Pir Mohammad , Naseem Swaleha 
Published: September 2024

ABSTRACTWaxes are a diverse class of organic compounds that are characterised by their hydrophobic nature. They are typically derived from long‐chain fatty acids and alcohols. Waxes serve various purposes in nature and industry due to their unique physical and chemical properties. Waxes find applications in diverse industries, including pharmaceuticals, food and textiles, for purposes such as coating, lubrication and insulation. The rising emphasis on sustainable and eco‐friendly approaches in the food sector has generated increasing attention towards the advancement of edible coatings for food products. Within this array of coatings, sustainable waxes have surfaced as a prospective approach to improve storage stability, safety and quality of diverse food items. Bio‐based wax nanoemulsions serve as effective nanocarriers in edible food coatings, enhancing their antimicrobial efficacy and preserving food quality. The incorporation of bio‐based nanoemulsion waxes as edible coatings signifies a substantial advancement towards establishing more environmentally sustainable and ecologically responsible systems of food packaging and preservation. The review examines recent advancements in the field of sustainable nanoemulsion waxes as edible coatings, focusing on their applications, formulation strategies and impact on food commodities. The review also discusses the influence of sustainable nanoemulsion wax coatings on the physicochemical properties of coated foods, including moisture barrier, gas permeability and mechanical strength.
Early autologous and/or allogeneic stem cell transplantation for adult patients with advanced stage T- lymphoblastic leukemia/lymphoma or Burkitt lymphoma. A retrospective single-centre analysis
Authors: Steiner N. , Baier K. , Ritter D. , Rudzki J. , Hetzenauer G. , Köck S. , Kircher B. , Gunsilius E. , Wolf D. , Nachbaur D. 
Published: September 2024

AbstractT-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) and Burkitt lymphoma (BL) are uncommon, highly aggressive diseases originating either from immature precursor T cells or from mature B cells in BL. We retrospectively analyzed the outcome of an early autologous and/or allogeneic stem cell transplantation (SCT) concept in 28 patients with advanced stage T-ALL/LBL and BL after three to four remission induction/consolidation chemotherapy cycles. Considering only patients in first complete remission (CR), the 5-year overall survival (OS) and event-free survival (EFS) was 91% in patients with BL and 73% in patients with T-ALL/LBL with a 5-year relapse incidence (RI) of 9% in patients with BL and 27% in patients with T-ALL/LBL. All relapsing patients finally succumbed to the disease (n = 10) or complications/toxicity after having received a salvage allogeneic transplant (n = 5). Despite the low patient number our retrospective single-centre analysis by incorporating an early intensive high-dose chemo-/radiotherapy strategy with either autologous or allogeneic stem cell transplantation, although preliminary, show promising long-term outcome. Further studies are highly warranted to better define those patients who might benefit most from such a treatment approach.
"Evaluation of spinel ferrites magnetic nanoparticles based hyperthermia: in-vitro study"
Authors: Abdelrahman Ahmed A. , Raboh Ahmed S. Abd , Ismail Mahmoud M. , El-Bahnasawy H. H. , Rayan Diaa A. 
Published: September 2024

AbstractThis study is an attempt to compare the hyperthermia and antimicrobial activity of three members of the family of spinel ferrite magnetic nanoparticles (XFe2O4, where X = Mg, Cu, and CO) MNPs. Spinell ferrite of MgFe2O4, CuFe2O4, and CoFe2O4 were prepared via sol–gel method. Structural and morphological shapes were investigated by different techniques X-ray diffraction X-ray powder diffractometer (XRD), Fourier transformed infrared spectroscopy (FTIR), and (Transmission electron microscope) TEM. Magnetic properties were examined by vibrating sample magnetometer (VSM). The in vitro test was conducted on cervical Hela cells using an MTT assay. Finally, the antimicrobial activity was tested on Staphylococcus aureus, Bacillus subtlus, and Escherichia coli using a clearing inhibition zone. XRD results confirmed the crystalline nature of MgFe2O4, CuFe2O4, and CoFe2O4. VSM results showed a high maximum saturation (Ms = 44.87 emu/g) of CuFe2O4 which is greater than that of CoFe2O4 and MgFe2O4 (18.221 and 18.669) emu/g, respectively. MTT assay revealed that high cell death was detected on Hela cells of CuFe2O4 compared to that of MgFe2O4 and CoFe2O4. The anti-microbial study showed that the prepared spinel magnetic nanoparticles possessed antimicrobial activity due to the release of Mg, Cu, Co, and Fe ions. Results showed that the CuFe2O4 could be a good spinel ferrite for medical application with antimicrobial activity and generate heat (hyperthermia, anti-cancer material).