bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevation correction of ERA‐Interim temperature data in the Tibetan Plateau
Authors: Gao Lu , Bernhardt Matthias , Schulz Karsten , Chen Xingwei 
Published: December 2016

ABSTRACTThe near surface air temperature is the primary indicator for climate change. Reanalysis as the surrogates for large‐scale observations are widely used in the Tibetan Plateau because of the sparse meteorological network. However, an average bias of −3.54 °C and root‐mean‐square error (RMSE) of 4.31 °C were found between ERA‐Interim monthly 2‐m temperature and observation over the Tibetan Plateau, which indicated that a correction procedure for ERA‐Interim is necessary before local scale applications. To overcome this challenge, a robust elevation correction method is developed to downscale ERA‐Interim 2° × 2° monthly 2‐m temperature data based on ERA‐Interim internal vertical lapse rates. This method is validated against 80 meteorological stations from 1979 to 2013 located in 26 ERA‐Interim grid cells. It is also compared with other four correction methods, which are using different lapse rate schemes such as fixed monthly lapse rates, surface lapse rates calculated from the meteorological stations (within a single grid or with neighbouring sites), as well as a third‐order curvilinear function of ERA‐Interim pressure level data. The results indicate that the correction method using ERA‐Interim internal vertical lapse rates cannot only significantly reduce the bias (89%) and RMSE (62%) for the original ERA‐Interim data, but also capture the inter‐annual variations for the plateau‐wide climatology very well. The seasonal and annual temperature warming trends are also modelled encouragingly compared with other four methods. The strongest advantage of this method is that it is independent of local meteorological stations. Therefore, it is possible to extrapolate ERA‐Interim temperature data for any other high mountain areas where no measurements exist. This work will help the scientific community identify the most proper and easiest method to downscale reanalysis temperature data for climate impact assessments at the site or regional scale.
The burden of childhood cancer in Mexico: Implications for low‐ and middle‐income countries
Authors: Rivera‐Luna Roberto , Zapata‐Tarres Marta , Shalkow‐Klincovstein Jaime , Velasco‐Hidalgo Liliana , Olaya‐Vargas Alberto , Finkelstein‐Mizrahi Nicole , Cárdenas‐Cardós Rocío , Aguilar‐Ortiz Marco R. 
Published: December 2016

AbstractIn Mexico, childhood cancer incidence and mortality have increased in the last decade. Through government actions since 2005, the Popular Medical Insurance (PMI) program for childhood cancer was created. The objective of PMI was to offer early cancer diagnosis, standardized treatment regimens, and numerous pediatric oncology residency programs. It has also accredited 55 national hospitals for the care of these children. Current problems still present under the PMI include shortage of pediatric oncologists and nurses and high rate of abandonment of treatment. Our aim is to describe the current scenario of childhood cancer care in Mexico, especially from the perspective of the PMI and how it has impacted human resources, infrastructure, and medical education.
Statistical learning: a powerful mechanism that operates by mere exposure
Authors: Aslin Richard N. 
Published: December 2016

How do infants learn so rapidly and with little apparent effort? In 1996, Saffran, Aslin, and Newport reported that 8‐month‐old human infants could learn the underlying temporal structure of a stream of speech syllables after only 2 min of passive listening. This demonstration of what was called statistical learning, involving no instruction, reinforcement, or feedback, led to dozens of confirmations of this powerful mechanism of implicit learning in a variety of modalities, domains, and species. These findings reveal that infants are not nearly as dependent on explicit forms of instruction as we might have assumed from studies of learning in which children or adults are taught facts such as math or problem solving skills. Instead, at least in some domains, infants soak up the information around them by mere exposure. Learning and development in these domains thus appear to occur automatically and with little active involvement by an instructor (parent or teacher). The details of this statistical learning mechanism are discussed, including how exposure to specific types of information can, under some circumstances, generalize to never‐before‐observed information, thereby enabling transfer of learning. WIREs Cogn Sci 2017, 8:e1373. doi: 10.1002/wcs.1373This article is categorized under:

Psychology > Learning
Early experience and brain development
Authors: Bick Johanna , Nelson Charles A. 
Published: December 2016

Healthy brain development takes place within the context of individual experience. Here, we describe how certain early experiences are necessary for typical brain development. We present evidence from multiple studies showing that severe early life neglect leads to alterations in brain development, which compromises emotional, behavioral, and cognitive functioning. We also show how early intervention can reverse some of the deleterious effects of neglect on brain development. We conclude by emphasizing that early interventions that start at the earliest possible point in human development are most likely to support maximal recovery from early adverse experiences. WIREs Cogn Sci 2017, 8:e1387. doi: 10.1002/wcs.1387This article is categorized under:

Psychology > Development and Aging
The heritability fallacy
Authors: Moore David S. , Shenk David 
Published: December 2016

The term ‘heritability,’ as it is used today in human behavioral genetics, is one of the most misleading in the history of science. Contrary to popular belief, the measurable heritability of a trait does not tell us how ‘genetically inheritable’ that trait is. Further, it does not inform us about what causes a trait, the relative influence of genes in the development of a trait, or the relative influence of the environment in the development of a trait. Because we already know that genetic factors have significant influence on the development of all human traits, measures of heritability are of little value, except in very rare cases. We, therefore, suggest that continued use of the term does enormous damage to the public understanding of how human beings develop their individual traits and identities. WIREs Cogn Sci 2017, 8:e1400. doi: 10.1002/wcs.1400This article is categorized under:

Cognitive Biology > Genes and Environment
Neuroscience > Development
Educating executive function
Authors: Blair Clancy 
Published: December 2016

Executive functions are thinking skills that assist with reasoning, planning, problem solving, and managing one's life. The brain areas that underlie these skills are interconnected with and influenced by activity in many different brain areas, some of which are associated with emotion and stress. One consequence of the stress‐specific connections is that executive functions, which help us to organize our thinking, tend to be disrupted when stimulation is too high and we are stressed out, or too low when we are bored and lethargic. Given their central role in reasoning and also in managing stress and emotion, scientists have conducted studies, primarily with adults, to determine whether executive functions can be improved by training. By and large, results have shown that they can be, in part through computer‐based videogame‐like activities. Evidence of wider, more general benefits from such computer‐based training, however, is mixed. Accordingly, scientists have reasoned that training will have wider benefits if it is implemented early, with very young children as the neural circuitry of executive functions is developing, and that it will be most effective if embedded in children's everyday activities. Evidence produced by this research, however, is also mixed. In sum, much remains to be learned about executive function training. Without question, however, continued research on this important topic will yield valuable information about cognitive development. WIREs Cogn Sci 2017, 8:e1403. doi: 10.1002/wcs.1403This article is categorized under:

Psychology > Attention
Psychology > Learning
Genes, behavior, and behavior genetics
Authors: Charney Evan 
Published: December 2016

According to the ‘first law’ of behavior genetics, ‘All human behavioral traits are heritable.’ Accepting the validity of this first law and employing statistical methods, researchers within psychology, sociology, political science, economics, and business claim to have demonstrated that all the behaviors studied by their disciplines are heritable—no matter how culturally specific these behaviors appear to be. Further, in many cases they claim to have identified specific genes that play a role in those behaviors. The validity of behavior genetics as a discipline depends upon the validity of the research methods used to justify such claims. It also depends, foundationally, upon certain key assumptions concerning the relationship between genotype (one's specific DNA sequences) and phenotype (any and all observable traits or characteristics). In this article, I examine—and find serious flaws with—both the methodologies of behavior genetics and the underlying assumptions concerning the genotype–phenotype relationship. WIREs Cogn Sci 2017, 8:e1405. doi: 10.1002/wcs.1405This article is categorized under:

Cognitive Biology > Genes and Environment
Neuroscience > Genes, Molecules, and Cells
Neuroembryology
Authors: Darnell Diana , Gilbert Scott F. 
Published: December 2016

How is it that some cells become neurons? And how is it that neurons become organized in the spinal cord and brain to allow us to walk and talk, to see, recall events in our lives, feel pain, keep our balance, and think? The cells that are specified to form the brain and spinal cord are originally located on the outside surface of the embryo. They loop inward to form the neural tube in a process called neurulation. Structures that are nearby send signals to the posterior neural tube to form and pattern the spinal cord so that the dorsal side receives sensory input and the ventral side sends motor signals from neurons to muscles. In the brain, stem cells near the center of the neural tube migrate out to form a mantel zone, and a set of dividing cells from the mantle zone migrate further to produce a second set of neurons at the outer surface of the brain. These neurons will form the cerebral cortex, which contains six discrete layers. Each layer has different connections and different functions. WIREs Dev Biol 2017, 6:e215. doi: 10.1002/wdev.215This article is categorized under:

Early Embryonic Development > Gastrulation and Neurulation
Early Embryonic Development > Development to the Basic Body Plan
Association Between BMI and Recurrence of Primary Spontaneous Pneumothorax
Authors: Tan Juntao , Yang Yang , Zhong Jianhong , Zuo Chuantian , Tang Huamin , Zhao Huimin , Zeng Guang , Zhang Jianfeng , Guo Jianji , Yang Nuo 
Published: December 2016

AbstractBackgroundWhether body mass index (BMI) is a significant risk factor for recurrence of primary spontaneous pneumothorax (PSP) remains controversial. The purpose of this study was to examine whether BMI and other factors are linked to risk of PSP recurrence.MethodsA consecutive cohort of 273 patients was retrospectively evaluated. Patients were divided into those who experienced recurrence (n = 81) and those who did not (n = 192), as well as into those who had low BMI (n = 75) and those who had normal or elevated BMI (n = 198). The two pairs of groups were compared in terms of baseline data, and Cox proportional hazards modeling was used to identify predictors of PSP recurrence.ResultsRates of recurrence among all 273 patients were 20.9% at 1 year, 23.8% at 2 years, and 28.7% at 5 years. Univariate analysis identified the following significant predictors of PSP recurrence: height, weight, BMI, size of pneumothorax, and treatment modality. Multivariate analyses identified several risk factors for PSP recurrence: low BMI, pneumothorax size ≥50%, and non‐surgical treatment. Kaplan–Meier survival analysis indicated that patients with low BMI showed significantly lower recurrence‐free survival than patients with normal or elevated BMI (P < 0.001).ConclusionsLow BMI, pneumothorax size ≥50%, and non‐surgical treatment were risk factors for PSP recurrence in our cohort. Low BMI may be a clinically useful predictor of PSP recurrence.
Advances in endovascular therapy for ischemic cerebrovascular diseases
Authors: Lu Jun , Wang Daming 
Published: December 2016

AbstractEndovascular therapy for ischemic cerebrovascular diseases has developed rapidly in recent years. The latest clinical trials of acute ischemic stroke have shown promising results with the continued advancement of concepts, techniques, and materials. Mechanical thrombectomy is recommended in the treatment of acute ischemic stroke caused by large vessel occlusion of the anterior circulation, according to the guidelines updated in Europe, USA, and China. The long‐term therapeutic efficacy of endovascular stenting for carotid artery stenosis has also been proved noninferior to that of carotid endarterectomy. However, the latest clinical trials have shown that the efficacy of stenting for intracranial artery and vertebral artery stenosis is inferior to that of medical treatment alone, which needs urgent attention through further development and studies.
Standards for Clinical Trials in Male and Female Sexual Dysfunction: II. Patient-Reported Outcome Measures
Authors: Fisher William A. , Gruenwald Ilan , Jannini Emmanuele A. , Lev-Sagie Ahinoam , Lowenstein Lior , Pyke Robert E. , Reisman Yakov , Revicki Dennis A. , Rubio-Aurioles Eusebio 
Published: December 2016

ABSTRACTThe second article in this series, Standards for Clinical Trials in Male and Female Sexual Dysfunction, focuses on measurement of patient-reported outcomes (PROs). Together with the design of appropriate phase I to phase IV clinical trials, the development, validation, choice, and implementation of valid PRO measurements—the focus of the present article—form the foundation of research on treatments for male and female sexual dysfunctions. PRO measurements are assessments of any aspect of a patient's health status that come directly from the patient (ie, without the interpretation of the patient's responses by a physician or anyone else). PROs are essential for assessing male and female sexual dysfunction and treatment response, including symptom frequency and severity, personal distress, satisfaction, and other measurements of sexual and general health-related quality of life. Although there are some relatively objective measurements of sexual dysfunction (ie, intravaginal ejaculatory latency time, frequency of sexual activity, etc), these measurements do not comprehensively assess the occurrence and extent of sexual dysfunction or treatment on the patient's symptoms, functioning, and well-being. Data generated by a PRO instrument can provide evidence of a treatment benefit from the patient's perspective.
Standards for Clinical Trials in Male and Female Sexual Dysfunction: I. Phase I to Phase IV Clinical Trial Design
Authors: Fisher William A. , Gruenwald Ilan , Jannini Emmanuele A. , Lev-Sagie Ahinoam , Lowenstein Lior , Pyke Robert E. , Reisman Yakov , Revicki Dennis A. , Rubio-Aurioles Eusebio 
Published: December 2016

ABSTRACTThis series of articles outlines standards for clinical trials of treatments for male and female sexual dysfunctions, with a focus on research design and patient-reported outcome assessment. These articles consist of revision, updating, and integration of articles on standards for clinical trials in male and female sexual dysfunction from the 2010 International Consultation on Sexual Medicine developed by the authors as part of the 2015 International Consultation on Sexual Medicine. We are guided in this effort by several principles. In contrast to previous versions of these guidelines, we merge discussion of standards for clinical trials in male and female sexual dysfunction in an integrated approach that emphasizes the common foundational practices that underlie clinical trials in the two settings. We present a common expected standard for clinical trial design in male and female sexual dysfunction, a common rationale for the design of phase I to IV clinical trials, and common considerations for selection of study population and study duration in male and female sexual dysfunction. We present a focused discussion of fundamental principles in patient- (and partner-) reported outcome assessment and complete this series of articles with specific discussions of selected aspects of clinical trials that are unique to male and to female sexual dysfunction. Our consideration of standards for clinical trials in male and female sexual dysfunction attempts to embody sensitivity to existing and new regulatory guidance and to address implications of the evolution of the diagnosis of sexual dysfunction that have been brought forward in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. The first article in this series focuses on phase I to phase IV clinical trial design considerations. Subsequent articles in this series focus on the measurement of patient-reported outcomes, unique aspects of clinical trial design for men, and unique aspects of clinical trial design for women.
The Influence of Test Positions on Clinical Assessment for Scapular Dyskinesis
Authors: Deng Simin , Chen Kang , Ma Yanhong , Chen Juan , Huang Mi 
Published: December 2016

AbstractBackgroundAppropriate evaluation of scapular dyskinesis is essential for therapeutic strategies. Although the current visual‐based assessment is rapid and practical, the reliability of this method is unsatisfactory. It is necessary to adequately understand the conditions of assessment to maximize the benefit of therapeutic interventions.ObjectiveTo explore the influence of different test positions on clinical assessment for scapular dyskinesis.DesignObservational study.SettingUniversity rehabilitation department.PatientsA total of 102 subjects diagnosed with unilateral shoulder disorder were recruited from among rehabilitation outpatients from November 2015 to February 2016.MethodsTwo experienced raters categorized the subjects' scapular movement pattern according to Kibler et al classification by the vision‐palpation method at 4 test positions (at rest, and the end range of elevation in the sagittal, scapular, and coronal planes).Main Outcome MeasurementsThe overall prevalence of scapular dyskinesis, the distribution of types, and the reproducibility of types at the 4 test positions were analyzed.ResultsThe overall prevalence of scapular dyskinesis was 90.08%, and the highest frequency was found at the resting position. Type III was the most common type in our sample. In reproducibility analysis, 21.57% of subjects presented with the same type at any position, and 75.49% of subjects presented with 2 types.ConclusionsScapular dyskinesis in individuals with shoulder disorder showed a high prevalence, especially at the resting position. More than 1 type of scapular pattern would be present if assessed at different positions. This study indicates that test positions can affect the results of scapular dyskinesis assessment, and that the resting position should primarily be applied.Level of EvidenceIII
The generation of gravity–capillary solitary waves by a pressure source moving at a trans-critical speed
Authors: Masnadi Naeem , Duncan James H. 
Published: December 2016

The unsteady response of a water free surface to a localized pressure source moving at constant speed $U$ in the range $0.95c_{min}\lesssim U\leqslant 1.02c_{min}$, where $c_{min}$ is the minimum phase speed of linear gravity–capillary waves in deep water, is investigated through experiments and numerical simulations. This unsteady response state, which consists of a V-shaped pattern behind the source, and features periodic shedding of pairs of depressions from the tips of the V, was first observed qualitatively by Diorio et al. (Phys. Rev. Lett., vol. 103, 2009, 214502) and called state III. In the present investigation, cinematic shadowgraph and refraction-based techniques are utilized to measure the temporal evolution of the free-surface deformation pattern downstream of the source as it moves along a towing tank, while numerical simulations of the model equation described by Cho et al. (J. Fluid Mech., vol. 672, 2011, pp. 288–306) are used to extend the experimental results over longer times than are possible in the experiments. From the experiments, it is found that the speed–amplitude characteristics and the shape of the depressions are nearly the same as those of the freely propagating gravity–capillary lumps of inviscid potential theory. The decay rate of the depressions is measured from their height–time characteristics, which are well fitted by an exponential decay law with an order one decay constant. It is found that the shedding period of the depression pairs decreases with increasing source strength and speed. As the source speed approaches $c_{min}$, this period tends to approximately 1 s for all source magnitudes. At the low-speed boundary of state III, a new response with unsteady asymmetric shedding of depressions is found. This response is also predicted by the model equation.
THE STRENGTH OF THE TREE THEOREM FOR PAIRS IN REVERSE MATHEMATICS
Authors: PATEY LUDOVIC 
Published: December 2016

AbstractNo natural principle is currently known to be strictly between the arithmetic comprehension axiom (ACA0) and Ramsey’s theorem for pairs ($RT_2^2$) in reverse mathematics. The tree theorem for pairs ($TT_2^2$) is however a good candidate. The tree theorem states that for every finite coloring over tuples of comparable nodes in the full binary tree, there is a monochromatic subtree isomorphic to the full tree. The principle $TT_2^2$ is known to lie between ACA0 and $RT_2^2$ over RCA0, but its exact strength remains open. In this paper, we prove that $RT_2^2$ together with weak König’s lemma (WKL0) does not imply $TT_2^2$, thereby answering a question of Montálban. This separation is a case in point of the method of Lerman, Solomon and Towsner for designing a computability-theoretic property which discriminates between two statements in reverse mathematics. We therefore put the emphasis on the different steps leading to this separation in order to serve as a tutorial for separating principles in reverse mathematics.
CLASS FORCING, THE FORCING THEOREM AND BOOLEAN COMPLETIONS
Authors: HOLY PETER , KRAPF REGULA , LÜCKE PHILIPP , NJEGOMIR ANA , SCHLICHT PHILIPP 
Published: December 2016

AbstractThe forcing theorem is the most fundamental result about set forcing, stating that the forcing relation for any set forcing is definable and that the truth lemma holds, that is everything that holds in a generic extension is forced by a condition in the relevant generic filter. We show that both the definability (and, in fact, even the amenability) of the forcing relation and the truth lemma can fail for class forcing.In addition to these negative results, we show that the forcing theorem is equivalent to the existence of a (certain kind of) Boolean completion, and we introduce a weak combinatorial property (approachability by projections) that implies the forcing theorem to hold. Finally, we show that unlike for set forcing, Boolean completions need not be unique for class forcing.
DESCRIPTIONS AND CARDINALS BELOW
Authors: JACKSON STEVE , KHAFIZOV FARID T. 
Published: December 2016

AbstractAssuming AD, we show that all of the ordinals below $\delta _5^1$ represented by descriptions (c.f. [2], but also defined below) are cardinals. Using this analysis we also get a simple representation for the cardinal structure below $\delta _5^1$. As an application, we compute the cofinalitites of all cardinals below $\delta _5^1$.