bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Medications and Herpes Zoster in Japanese Patients with Rheumatoid Arthritis: A 5-year Prospective Cohort Study
Authors: Harada Sayoko , Sakai Ryoko , Hirano Fumio , Miyasaka Nobuyuki , Harigai Masayoshi 
Published: April 2017

Objective.To investigate the association between medications and herpes zoster (HZ) in patients with rheumatoid arthritis (RA) given biological disease-modifying antirheumatic drugs (bDMARD) or conventional synthetic DMARD in the clinical setting during 5 years using the Registry of Japanese Rheumatoid Arthritis Patients on Biologics for Longterm Safety (REAL) database.Methods.We calculated the crude incidence rate (IR) of HZ treated with systemic antiviral medications in 1987 patients from the REAL database. To estimate the association between HZ and medications, a nested case control study was performed with 1:5 case-control pairs matched for age, sex, observation start year, and comorbidity (HZ case group, n = 43; control group, n = 214). We calculated OR and 95% CI of the use of bDMARD, methotrexate (MTX), and corticosteroids for the occurrence of HZ using a conditional logistic regression analysis.Results.The median patient age was 60.0 years, female proportion was 81.5%, and median disease duration was 6.0 years. The crude IR (95% CI) of HZ was 6.66 (4.92–8.83)/1000 person-years. The OR (95% CI) of medication use were 2.28 (1.09–4.76) for tumor necrosis factor inhibitor (TNFi) and 1.13 (1.03–1.23) for oral corticosteroids dosage (per 1 mg prednisolone increment), both of which were significantly elevated. The OR of non-TNFi and MTX usage were not elevated.Conclusion.TNFi use and higher corticosteroids dosage were significantly associated with HZ in Japanese patients with RA in the clinical setting.
Validity and Reliability of Patient Reported Outcomes Measurement Information System Computerized Adaptive Tests in Systemic Lupus Erythematosus
Authors: Kasturi Shanthini , Szymonifka Jackie , Burket Jayme C. , Berman Jessica R. , Kirou Kyriakos A. , Levine Alana B. , Sammaritano Lisa R. , Mandl Lisa A. 
Published: April 2017

Objective.The aims of this study were to assess the construct validity and the test-retest reliability of Patient Reported Outcomes Measurement Information System (PROMIS) computerized adaptive tests (CAT) in patients with systemic lupus erythematosus (SLE).Methods.Adults with SLE completed the Medical Outcomes Study Short Form-36, LupusQoL-US version (“legacy instruments”), and 14 selected PROMIS CAT. Using Spearman correlations, PROMIS CAT were compared with similar domains measured with legacy instruments. CAT were also correlated with the Safety of Estrogens in Lupus Erythematosus National Assessment–Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI) disease activity and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) scores. Test-retest reliability was evaluated using ICC.Results.There were 204 outpatients with SLE enrolled in the study and 162 completed a retest. PROMIS CAT showed good performance characteristics and moderate to strong correlations with similar domains in the 2 legacy instruments (r = −0.49 to 0.86, p < 0.001). However, correlations between PROMIS CAT and the SELENA-SLEDAI disease activity and SDI were generally weak and statistically insignificant. PROMIS CAT test-retest ICC were good to excellent, ranging from 0.72 to 0.88.Conclusion.To our knowledge, these data are the first to show that PROMIS CAT are valid and reliable for many SLE-relevant domains. Importantly, PROMIS scores did not correlate well with physician-derived measures. This disconnect between objective signs and symptoms and the subjective patient disease experience underscores the crucial need to integrate patient-reported outcomes into clinical care to ensure optimal disease management.
Endocrine Comorbidities in Patients with Psoriatic Arthritis: A Population-based Case-controlled Study
Authors: Haddad Amir , Ashkenazi Ron Ilan , Bitterman Haim , Feldhamer Ilan , Greenberg-Dotan Sari , Lavi Idit , Batat Erez , Bergman Irina , Cohen Arnon Dov , Zisman Devy 
Published: April 2017

Objective.To investigate endocrine comorbidities in patients with psoriatic arthritis (PsA).Methods.A retrospective, cross-sectional study was performed with the database of Clalit Health Services, the largest healthcare provider in Israel, between 2002 and 2014. Patients with PsA were identified and matched by age and sex to healthy controls. The following morbidities were analyzed: hypo/hyperthyroidism, hypo/hyperparathyroidism, hyperprolactinemia, Cushing disease, Addison disease, diabetes insipidus, diabetes mellitus (DM), pituitary adenoma, acromegaly, and osteoporosis. Descriptive statistics were applied. The associations between PsA and endocrine comorbidities were analyzed by univariable and multivariable analysis.Results.The study included 3161 patients with PsA, 53.4% women, mean age 58.4 ± 15.4 years, and 31,610 controls. Comparative analyses yielded higher proportion of hypothyroidism (12.7% vs 8.6%, p < 0.0001), Cushing disease (0.3% vs 0.1%, p < 0.0001), osteoporosis (13.2% vs 9.1%, p < 0.0001), and DM (27.9% vs 20.7%, p < 0.0001) in the PsA group compared with the control group. In the multivariable regression analysis, the following diseases were more frequent in the PsA group: hypothyroidism (OR 1.61, 95% CI 1.47–1.81), DM (OR 1.35, 95% CI 1.18–1.42), Cushing disease (OR 3.96, 95% CI 1.67–9.43), and osteoporosis (OR 1.56, 95% CI 1.37–1.78).Conclusion.PsA is associated with a high frequency of hypothyroidism, osteoporosis, DM, and Cushing disease. Awareness of these comorbidities may help physicians provide the optimal medical care to patients with PsA.
Self-reported Diagnosis of Rheumatoid Arthritis or Ankylosing Spondylitis Has Low Accuracy: Data from the Nord-Trøndelag Health Study
Authors: Videm Vibeke , Thomas Ranjeny , Brown Matthew A. , Hoff Mari 
Published: April 2017

Objective.Self-reported diagnoses of inflammatory arthritis are not accurate. The primary study aim was to ascertain self-reported diagnoses of rheumatoid arthritis (RA) and ankylosing spondylitis (AS) in the Norwegian population-based Nord-Trøndelag Health Study (HUNT) using hospital case files. The secondary aim was to provide updated estimates of the prevalence and incidence of RA and AS.Methods.All inhabitants ≥ 20 years old from the county of Nord-Trøndelag were invited. Data from 70,805 unique participants from HUNT2 (1995–1997) and HUNT3 (2006–2008) were included. For participants who self-reported RA or AS, case files from all 3 hospitals in the catchment area were evaluated using standardized diagnostic criteria.Results.Of 2703 self-reported cases of RA, 19.1% were verified in hospital files. Of 1064 self-reported cases of AS, 15.8% were verified. Of 259 cases self-reporting both RA and AS, 8.1% had RA and 5.4% had AS. Overall, a self-report of 1 or both diagnoses could not be verified in 82.1%, including 22.8% with insufficient information or no case file. The prevalence of RA was 768 (95% CI 705–835) per 100,000. The incidence of RA from HUNT2 to HUNT3 was 0.48 (0.41–0.56) per 1000 per year. The prevalence of AS was 264 (228–305) per 100,000. The incidence of AS from HUNT2 to HUNT3 was 0.19 (0.15–0.24) per 1000 per year.Conclusion.Self-reported diagnoses of RA and AS are often false-positive. The prevalence and incidence of RA were comparable to reports from similar populations. The incidence of AS was higher than previously reported in a mixed population from Norway.
Case-control Study on Dactylitis, Enthesitis, and Anterior Uveitis in Spondyloarthritis Associated with Inflammatory Bowel Diseases: Role of Coexistent Psoriasis
Authors: Cantini Fabrizio , Niccoli Laura , Nannini Carlotta , Cassarà Emanuele , Kaloudi Olga , Rizzello Fernando , Gionchetti Paolo 
Published: April 2017

Objective.To evaluate the frequency of dactylitis, enthesitis, and anterior uveitis (AU) in spondyloarthritis (SpA) associated with inflammatory bowel disease (IBD-SpA) compared with other SpA, and to assess the role of associated psoriasis in the occurrence of dactylitis and enthesitis.Methods.In a 12-month case-control study, the frequency of dactylitis and enthesitis in 29 patients with ulcerative colitis (UC) and 59 with Crohn disease (CD) who satisfied the Spondyloarthritis international Society criteria for axial or peripheral SpA was compared with 176 controls, including 97 (55.1%) with psoriatic arthritis (PsA), 47 (26.7%) with ankylosing spondylitis (AS), and 32 (18.2%) with nonradiographic axial SpA (nr-axSpA). The occurrence of these features in IBD-SpA with and without psoriasis was also evaluated.Results.Axial, peripheral, or mixed involvement was observed in 46 (52%), 29 (33%), and 13 (15%) patients, respectively; and 14/88 (16%) had psoriasis. Dactylitis was recorded in 4/88 patients (4.5%) with IBD-SpA and in 30 controls (17.4%; p = 0.008), enthesitis in 16 cases (18.1%) and in 78/176 controls (44.3%; p < 0.001), and AU in 3 patients (3.4%) with IBD-SpA and in 26 controls (14.7%; p = 0.01). No significant differences were found between patients with UC-SpA and those with CD-SpA. Dactylitis and enthesitis were significantly more common in patients with IBD-SpA who also had psoriasis compared to those without skin disease (p = 0.009 and 0.003, respectively).Conclusion.Dactylitis, enthesitis, and AU are significantly less frequent in IBD-SpA compared with other types of SpA. Given the frequent association of psoriasis and IBD, overlooking coexistent skin disease may lead to overestimating the frequency of these features.
« Nous vieillirons ensemble »Destins des retrouvailles à l’orée de la retraite chez les femmes
Authors: Siaugues Caroline , Verdon Benoît 
Published: April 2017

L’expérience du passage à la retraite paraît à même d’induire le trouble sur la scène psychique de bien des femmes. Souvent l’objet d’une chère attente associée au mérite et à la délivrance, la retraite professionnelle marque aussi l’avancée en âge et ne peut donc être pensée sans les problématiques qu’engage la traversée du vieillissement. À l’appui d’entretiens de recherche réalisés auprès de femmes retraitées, âgées entre 60 et 66 ans, cet article se propose d’appréhender tant la complexité que la singularité du travail psychique réclamé par cette expérience de passage en s’intéressant, plus particulièrement, aux retrouvailles avec le conjoint chez les femmes. Sous-tendues par la problématique de la dépendance et du vieillissement, ces retrouvailles peuvent mobiliser chez certaines la mise en place d’aménagements maniaques.
Matérialisme, eschatologie, nécessité
Authors: Untea Ionut 
Published: April 2017

Pendant la première moitié du xvii e siècle, les discours millénaristes enflamment l’imagination politique jusqu’au point d’inspirer l’exécution du roi Charles I er . À part sa portée politique, le projet millénariste anglais a aussi l’ambition de produire une vision scientifique de la manière dont la grâce divine agit sur les corps matériels. Arthur Dent, John Dury, Cheney Culpepper, Samuel Hartlib et Henry More font appel à l’image métaphorique de la pierre mise en mouvement par une puissance au-delà de toute force matérielle (Dn 2, 31-35). Afin de montrer que ce projet millénariste est insuffisamment fondé, même du point de vue théologique, Thomas Hobbes utilise la même image de la pierre, en lui donnant cette fois une interprétation dont le but est de souligner que les passions ne sont pas à mépriser. En intégrant la discussion sur les passions humaines dans sa vision scientifique sur le mouvement physique, Hobbes entend produire une théorie scientifique capable aussi d’être mise au service de l’unité religieuse et politique.
Les mots agonistiques des nouveaux discours féministes : l’exemple de grossophobie et cissexisme
Authors: Husson Anne-Charlotte 
Published: April 2017

Cet article choisit une entrée lexicale pour appréhender les discours et argumentations féministes contemporaines. Plus précisément, ce sont deux mots agonistiques qui servent de points d’entrée : grossophobie / grossophobe et cissexisme / cissexiste. Ces mots agonistiques sont caractéristiques d’une recherche d’inclusivité qui trouve sa source dans un débat (entamé dès les années 1970) sur le sujet politique du féminisme. L’analyse d’un corpus d’énoncés tirés du web (sites, blogs, forum et réseaux sociaux numériques) révèle qu’au-delà de leur dimension polémique, de tels mots s’inscrivent dans une vision du monde où la prise en compte de la multiplicité des identités et des appartenances sociales tient une place cruciale.
Le corps exhibé : un texte singulier du féminisme quatrième génération
Authors: Pahud Stéphanie 
Published: April 2017

Entre autres nouvelles élaborations argumentatives, la réflexion féministe contemporaine accueille un activisme non pas des mots, mais du corps : comme le relève Fraisse, si « le corps est évidemment partie prenante du fantasme et de l’image, au cœur des débats sur sexe et genre », il est aussi « une matière qui parle », « un langage de l’émancipation » (2014). La présente contribution prolongera cette observation en proposant une analyse discursive de corps féministes exhibés, ces derniers pouvant être considérés comme des textes de résistance. Elle sera plus précisément consacrée à une analyse discursive des pratiques corporelles du mouvement Femen, collectif féministe fondé en Ukraine en 2008, reconnaissable par sa nudité et ses « opérations coups de seins ». Il s’agira premièrement de décrire les particularités rhétoriques des corps-textes de ce mouvement : en adoptant des postures stéréotypiquement attribuées aux femmes et les stigmatisant, le collectif Femen investit politiquement le corps, et opère un détournement des exhibitions/aliénations (entre autres patriarcales) de ses performances. Enjeux et réception de ce retournement de stigmate seront discutés. Il s’agira également de réfléchir aux procédés discursifs de construction/déconstruction d’évidences sur le corps et aux modes possibles de repolitisation de ce dernier, envisagé ici comme instrument de communication/argumentation et comme lieu d’intelligibilité du social (Berthelot 1994).
Féminismes 2.0. Usages technodiscursifs de la génération connectée
Authors: Paveau Marie-Anne 
Published: April 2017

Les univers discursifs numériques ouverts par le Web social ont permis le développement rapide des discours militants exploitant la réticularité des espaces numériques et leur capacité relationnelle. Après une description des usages numériques natifs actuels des féministes et de leur genèse historique, on examine deux phénomènes caractérisant le discours féministe contemporain : le déploiement dans la blogosphère et les RSN féministes de formes discursives natives et spécifiques de resignification de contenus agressifs ou insultants envers les femmes ; l’usage de technographismes, productions composites articulant image et texte de manière indissociable (on développe les deux exemples du mème « We can do it! » et du bingo féministe, liste d’arguments antiféministes présentés en ligne sur une grille analogue à celle du célèbre jeu).
A Beurling Theorem for Generalized Hardy Spaces on a Multiply Connected Domain
Authors: Chen Yanni , Hadwin Don , Liu Zhe , Nordgren Eric 
Published: April 2017

AbstractThe object of this paper is to prove a version of the Beurling–Helson–Lowdenslager invariant subspace theorem for operators on certain Banach spaces of functions on a multiply connected domain in ℂ. The norms for these spaces are either the usual Lebesgue and Hardy space norms or certain continuous gauge norms. In the Hardy space case the expected corollaries include the characterization of the cyclic vectors as the outer functions in this context, a demonstration that the set of analytic multiplication operators is maximal abelian and reflexive, and a determination of the closed operators that commute with all analytic multiplication operators.
CM Periods, CM Regulators, and Hypergeometric Functions, I
Authors: Asakura Masanori , Otsubo Noriyuki 
Published: April 2017

AbstractWe prove the Gross–Deligne conjecture on CM periods for motives associated with H2 of certain surfaces fibered over the projective line. Then we prove for the same motives a formula which expresses the K1-regulators in terms of hypergeometric functions 3F2, and obtain a new example of non-trivial regulators.
Automated Reporting of Trainee Metrics Using Electronic Clinical Systems
Authors: Levin Jonathan C. , Hron Jonathan 
Published: April 2017

ABSTRACT

Background
The Accreditation Council for Graduate Medical Education has called for increased emphasis on reporting objective performance measures to trainees and programs. However, reporting of objective measures, including clinical volume, is largely omitted from training programs.

Objective
To use automated electronic medical systems at a tertiary pediatric care hospital to create a dashboard that reports objective trainee and program metrics, including clinical volume and diagnoses in a pediatrics residency.

Methods
We queried an enterprise data warehouse that aggregates data daily from multiple hospital systems to identify patient encounters during which senior pediatrics residents at Boston Children's Hospital had entered documentation over a 9-month period. From this query, we created a filterable dashboard to display clinical volume and diagnosis data by individual resident and in aggregate.

Results
A total of 44 of 45 senior residents (98%) in the program were included in analysis. We identified 12 198 patient encounters during which a senior pediatrics resident had entered documentation; these included a median of 332 inpatient encounters per resident, 122 emergency department encounters, and 84 outpatient encounters. The most common diagnoses stratified by clinical site were: inpatient – dehydration (median = 61); emergency department – long-term/current drug therapy (median = 16); and outpatient – encounter for immunization (median = 48).

Conclusions
We used electronic health record systems to generate performance dashboards for trainees in a pediatrics residency across different sites of care with reported volume by diagnosis. Our dashboards provide feedback to program leadership regarding individual and aggregate trainee experience and allow individual trainees to compare their clinical exposure to peers.
SMEs Management Practices in a Hostile Business Environment in Zimbabwe
Authors: Moyo Bekezela , Moyo Edinah 
Published: April 2017

A great deal of extant literature has emphasised the importance of SMEs role in the economic performance of any country. It is this realization that has propelled almost all countries to nurture their SMEs so as to achieve economic development. This paper intends to interrogate the management practices adopted by SMEs in Zimbabwe, particularly in Gweru metropolitan albeit the macro factors that bedevilled the country to date. To achieve this discussion, emphasis will be drawn to the adoption and adaptation of management practices by these SMEs particularly in four facets: management of human resources, cash management, management of capital assets, and management of the product/service. This is a conceptual paper and a qualitative research design is going to be used to define the methodology of this paper. A cross sectional survey is proposed for this study, using a sample size of fifty SMEs who will be chosen using purposive and snowballing sampling methods. Questionnaires will be administered on the chosen sample and this will be followed by semi-structured interviews on five cases that will constitute the main cases for discussion and confirmation. Data will be analysed using a thematically data analysis approach as put forth by respondents narrating their encounters.
Het Europees Hof voor de Rechten van de Mens en nationale integratiedebatten
Authors: van Bijsterveld Sophie 
Published: April 2017

The European Court on Human Rights and national integration debates – Compulsory mixed swimming in Swiss elementary school permitted
In a unanimous decision, the European Court of Human Rights (ECtHR) has accepted the refusal of an exemption of compulsory mixed swimming lessons for elementary school girls in Switzerland. The exemption was requested by the parents of the two girls as the requirement to let their daughters participate in those lessons was contrary to their religious conviction. The author discusses the decision in the light of national debates on integration and subscribes its outcome. Specific attention is paid to the ECtHR’s interpretation of the legitimacy of the aim of the Swiss authorities and the role of the numerical presence of Islam in the underlying Swiss court’s ruling which is upheld by ECtHR.
Backlash Against “Others”
Authors: Rhoades Gary 
Published: April 2017

Right wing populist movements are challenging established political parties and institutions, including higher education. The discourse and platforms of these movements are a nationalistic backlash against elites and “others” that are antithetical to all that universities at their best stand for. But universities would do well to refocus on class-based inequities that also underlie this shift, in ways that rebalance the global and local.
Trump and the Coming Revolution in Higher Education Internationalization
Authors: Altbach Philip G. , De Wit Hans 
Published: April 2017

The advent of the Trump Administration in the US along with Brexit in the UK and other changes in Europe will bring a major set of changes to internationalization. The US and the UK will be seen as less attractive for international students. It is likely that the immigration and visa restrictions will grow. Governmental support for programs such as Fulbright and ERASMUS are likely to be cut back. Perhaps most important, the spirit of internationalization in higher education is likely to change.
The American Academic Profession at Risk
Authors: Finkelstein Martin J. 
Published: April 2017

The Faculty Factor (Johns Hopkins University Press, 2016) creatively mines fresh—and heretofore unavailable—data sources to follow the fortunes of the American faculty through the lingering Great Global Recession of 2008. Building on The American Faculty (Johns Hopkins, 2006), Finkelstein and Schuster, now joined by Valerie Martin Conley, document the emergence of a “new” model of academic work and careers in the United States built on an increasingly contingent, stratified academic workforce; the unbundling of the traditionally integrated role into specialist teaching, research and administrative roles, and the progressive yielding of faculty authority on campus, even in academic matters, to a growing core of full-time professional administrators. This volume includes two chapters that explicitly place the U.S. faculty in international perspective.
Tajikistan: University Challenges and the Professoriate
Authors: Kataeva Zumrad 
Published: April 2017

Tajikistan's higher education sector has experienced significant challenges after the breakup of the Soviet Union followed by the civil war of 1992-1997. The situation and status of the professoriate throughout the Post-Soviet space has deteriorated, as salaries and professional development opportunities have spiraled downward. Liberalization of the economy and the promise of higher education access have led to a rise in the demand for higher education. Higher education institutions have had to hire lesser-prepared faculty as those more seasoned or talented among the professoriate left for the private sector or migrated abroad. Today, the compensation of faculty members in Tajikistan is not enough to cover living costs, forcing them to use a variety of strategies to survive. They work as translators, consultants, or private tutors. The Tajik higher education system needs to work on establishing policies and opportunities to better support the profession, especially if institutions of higher education are eager to compete in the growing global educational marketplace.