bluuebunny/crossref_metadata_2025_split huggingface dataset:
Provider Perspectives and Access to Palliative Care: An American Head and Neck Society (AHNS) Survey
Authors: Sriram Shreya , Owusu‐Boahene Akua , Gersten Rebecca A. , Gourin Christine G. 
Published: October 2024

ABSTRACTBackgroundTo explore provider perspectives about palliative care (PC) in head and neck cancer (HNC) care.MethodsA 25‐question electronic survey was disseminated to the membership of the American Head and Neck Society (AHNS) from April 10, 2023, through June 13, 2023.ResultsRespondents were most likely to refer to PC at symptomatic disease progression (52%) or terminal diagnosis (29%) rather than at initial diagnosis (17%). Participants less likely to refer to PC were less likely to refer to symptomatic progression (8% vs. 39%, p = 0.0006) or address advance directives (62% vs. 87%, p = 0.0406). Symptom burden questionnaires were used by only 29% of respondents. Discordance was identified between self‐reported and actual access to local inpatient and outpatient PC services.ConclusionsBarriers to PC identified include a lack of established optimal timing of PC referral, a perceived lack of local access to PC, and a lack of uniform standardized assessment of symptom burden.
Safe and potent anti‐CD19 CAR T‐cells with shRNA‐IL‐6 gene silencing element in patients with refractory or relapsed B‐cell acute lymphoblastic leukemia
Authors: Ma Jin‐Feng , Yan Jia‐Wei , Liu Mei‐Jing , Yan Chun‐Long , Tang Xiao‐Wen , Qiu Hui‐Ying , Miao Miao , Han Yue , Li Li‐Min , Kang Li‐Qing , Xu Nan , Yu Zhou , Tan Jing‐Wen , Zhu Hong‐Jia , Jia Xu , Zhang Zhi‐Zhi , Wang Miao , Dai Hai‐Ping , Yu Lei , Xue Sheng‐Li , Wu De‐Pei , Gong Wen‐Jie 
Published: October 2024

AbstractSevere cytokine release syndrome (sCRS) and immune effector cell‐associated neurotoxicity syndrome (ICANS) have limited the widespread use of chimeric antigen receptor T (CAR T)‐cell therapy. We designed a novel anti‐CD19 CAR (ssCART‐19) with a small hairpin RNA (shRNA) element to silence the interleukin‐6 (IL‐6) gene, hypothesizing it could reduce sCRS and ICANS by alleviating monocyte activation and proinflammatory cytokine release. In a post hoc analysis of two clinical trials, we compared ssCART‐19 with common CAR T‐cells (cCART‐19) in relapsed/refractory B‐cell acute lymphoblastic leukemia (r/r B‐ALL). Among 87 patients, 47 received ssCART‐19 and 40 received cCART‐19. Grade ≥3 CRS occurred in 14.89% (7/47) of the ssCART‐19 group versus 37.5% (15/40) in the cCART‐19 group (p = 0.036). ICANS occurred in 4.26% (2/47) of the ssCART‐19 group (all grade 1) compared to 15% (2/40) of the cCART‐19 group. Patients in the ssCART‐19 group showed comparable rates of treatment response (calculated with rates of complete remission and incomplete hematological recovery) were 91.49% (43/47) for ssCART‐19 and 85% (34/40) for cCART‐19 (p = 0.999). With a median follow‐up of 21.9 months, cumulative nonrelapse mortality was 10.4% for ssCART‐19 and 13.6% for cCART‐19 (p = 0.33). Median overall survival was 37.17 months for ssCART‐19 and 32.93 months for cCART‐19 (p = 0.40). Median progression‐free survival was 24.17 months for ssCART‐19 and 9.33 months for cCART‐19 (p = 0.23). These data support the safety and efficacy of ssCART‐19 for r/r B‐ALL, suggesting its potential as a promising therapy.
Flexible Behavioral Adjustment to Frustrative Nonreward in Anticipatory Behavior, but Not in Consummatory Behavior, Requires the Dorsal Hippocampus
Authors: Hagen Christopher , Hoxha Megi , Chitale Saee , White Andre O. , Ogallar Pedro M. , Expósito Alejandro N. , Agüera Antonio D. R. , Torres Carmen , Papini Mauricio R. , Sabariego Marta 
Published: October 2024

ABSTRACTThe hippocampus (HC) is recognized for its pivotal role in memory‐related plasticity and facilitating adaptive behavioral responses to reward shifts. However, the nature of its involvement in the response to reward downshifts remains to be determined. To bridge this knowledge gap, we explored the HC's function through a series of experiments in various tasks involving reward downshifts and using several neural manipulations in rats. In Experiment 1, complete excitotoxic lesions of the HC impaired choice performance in a modified T‐maze after reducing the quantity of sugar pellet rewards. In Experiment 2, chemogenetic inhibition of the dorsal HC (dHC) disrupted anticipatory behavior following a food‐pellet reward reduction. Experiments 3–5 impaired HC function by using peripheral lipopolysaccharide (LPS) administration. This treatment, which induces peripheral inflammation affecting HC function, significantly increased cytokine levels in the dHC (Experiment 3) and impaired anticipatory choice behavior (Experiment 4). None of these dorsal hippocampal manipulations affected consummatory responses in animals experiencing sucrose downshifts. Accordingly, we found no evidence of increased neural activation in either the dorsal or ventral HC, as measured by c‐Fos expression, after a sucrose downshift task involving consummatory suppression (Experiment 6). The results highlight the HC's pivotal role in adaptively modulating anticipatory behavior in response to a variety of situations involving frustrative nonreward, while having no effect on adjustments on consummatory behavior. The data supporting this conclusion were obtained under heterogeneous experimental conditions derived from a multi‐laboratory collaboration, ensuring the robustness and high reproducibility of our findings. Spatial orientation, memory update, choice of reward signals of different values, and anticipatory versus consummatory adjustments to reward downshift are discussed as potential mechanisms that could account for the specific effects observed from HC manipulations.
Effects of zinc supplementation on sleep quality in humans: A systematic review of randomized controlled trials
Authors: Jazinaki Mostafa Shahraki , Gheflati Alireza , Moghadam Mohammad Reza Shadmand Foumani , Hadi Saeid , Razavidarmian Maryam , Nezhad Masoud Yaghob , Akhtari Hale , Nematizadeh Mona , Safarian Mohammad 
Published: October 2024

AbstractBackground and AimsAlternative therapies, such as zinc supplementation, have been explored as potential interventions for sleep disorders. However, the efficacy of zinc supplementation in improving sleep quality remains uncertain. This systematic review aims to examine the impacts of zinc supplementation on sleep quality in humans.MethodsThe Web of Science, Medline, Scopus, and Google Scholar databases were comprehensively searched to find studies investigating the effect of zinc supplementation on sleep quality. After identifying relevant studies by screening, relevant data were extracted from them. The quality assessment was conducted using the Cochrane quality assessment tool.ResultsThis systematic review included eight studies. The interventions ranged from 4 to 48 weeks, with a daily dose of zinc supplementation varying between 10 and 73.3 mg. The majority of the evidence examined in this review pointed to the significant improvement effect of zinc supplementation on sleep quality in adults compared to the control groups. Furthermore, zinc supplementation did not have a significant effect on sleep disorders. However, there was no consensus about these findings. Also, the effect of supplementation on sleep duration in nonadults was contradictory.ConclusionsThis systematic review suggests that zinc supplementation may lead to improvements in sleep quality. However, more research, primarily clinical trials, is needed to clarify the beneficial effects of zinc supplementation on sleep quality with consideration of dietary zinc intake and the Recommended Dietary Allowances of zinc (RDA) in the different populations. It is also recommended to investigate the effect of zinc supplementation on sleep quality in people with zinc deficiency in future studies.
Identification of key ubiquitination‐related genes in gestational diabetes mellitus: A bioinformatics‐driven study
Authors: Dai Yuheng , Lu Sha , Hu Wensheng 
Published: October 2024

AbstractBackground and AimsGestational diabetes mellitus (GDM) is characterized by glucose intolerance that occurs during pregnancy. This study aimed to identify key ubiquitination‐related genes associated with GDM pathogenesis.MethodsMicroarray data from GSE154377 was analyzed to identify differentially expressed genes (DEGs) in GDM vs normal pregnancy samples. Weighted gene co‐expression network analysis was performed on ubiquitination‐related genes. Functional enrichment, protein‐protein interaction network, and TF‐mRNA‐miRNA interaction network analyses were conducted on differentially expressed ubiquitination‐related genes (DE‐URGs).ResultsWe identified 2337 DEGs and 65 DE‐URGs in GDM. Functional enrichment analysis of the 65 DE‐URGs revealed involvement in protein ubiquitination and ubiquitin‐dependent catabolic processes. Protein‐protein interaction network analysis identified 8 hub genes, including MAP1LC3C, USP26, USP6, UBE2U, USP2, USP43, UCHL1, and USP44. ROC curve analysis showed these hub genes have high diagnostic accuracy for GDM (AUC > 0.6). The TF‐mRNA‐miRNA interaction network suggested USP2 and UCHL1 may be key ubiquitination genes in GDM.ConclusionIn conclusion, this study contributes to our understanding of the molecular landscape of GDM by uncovering key ubiquitination‐related genes. These findings may serve as a foundation for further investigations, offering potential biomarkers and therapeutic targets for clinical applications in GDM management.
Comparing the effects of premarital booklet‐ and video‐based educations on the reproductive health literacy of engaged couples
Authors: Bahrami‐Samani Sanaz , Mohsenzadeh–Ledari Farideh , Omidvar Shabnam , Khafri Soraya , Mohsenian Hoda 
Published: October 2024

AbstractObjectivesThe aim of this study was to compare the effects of premarital booklet‐based education (BBE) and video‐based education (VBE) on engaged couples’ RHL.MethodsThis quasi‐experimental study was conducted in 2021–2022. The study population consisted of engaged couples who referred to Amirkola Premarital Counseling Center, Babol, Iran, to receive premarital counseling. One hundred and ten couples were purposefully recruited and randomly allocated to a 55‐couple BBE group and a 55‐couple VBE group. Participants in the BBE group received RH‐related education through an educational booklet, while participants in the VBE group received RH‐related education through 4 weekly RH‐related educational videos shared through WhatsApp. The Sexual and Reproductive Health Literacy questionnaire was used to assess RHL at three measurement time points, i.e., before, 4 weeks after, and 2 months after the intervention onset. The data were analyzed using the SPSS software (v. 23.0).ResultsThe mean score of RHL significantly increased in both BBE and VBE groups (p < 0.001). The time‐group interaction was also significant for the mean scores of the access to information, evaluation of information, and decision‐making and application dimensions (p < 0.05) and insignificant for the reading and understanding dimension of RHL (p = 0.56).ConclusionBoth premarital BBE and VBE are effective in significantly improving RHL among engaged couples, while the effects of VBE on some RHL dimensions are significantly more than BBE.
The aftermath of asbestos prohibition in industry and its association with malignant mesothelioma in the south of Iran: An enduring predicament yet to be resolved
Authors: Rezvani Alireza , Shahriarirad Reza , Jahanshahi Sahar , Fouladi Damoun , Tavallali Maryam , Ziaian Bizhan , Fallahi Mohammad Javad 
Published: October 2024

AbstractPurposeMalignant Mesothelioma (MM) is a rare malignancy of the serosa membranes with a high mortality rate and long latent period. The relationship between a group of mineral fibers known as asbestos and mesothelioma is now well accepted in which people can be exposed to these fibers by various means during their lifetime and has been its usage has banned in many countries, such as Iran, which announced its gradual elimination from 1999 over a period of 7 years by using safe substitutes. However, the mineral particles are able to sustain itself in the environment, air, water, and soil and on the other hand, symptoms may take up to half a century to develop in exposed individuals. Also, there remains a shortage of comprehensive investigation on the effects of asbestos exposure within the familial context (household or domestic exposure) or on individuals residing in proximity to asbestos mines or factories (environmental exposure). Based on the high number of MM cases in Iran, and also our hypothesis that residuals of asbestos in the environment and petroleum products may be the etiological factor for MM, we conducted this study to evaluate the clinic epidemiological features of MM in the south of Iran its relation to possible asbestos exposure.MethodsIn this study, we analyzed the demographic features and occupations of confirmed cases of MM in Shiraz, southern Iran along with the follow‐up of the patients’ disease from 2008 to 2018, while also comparing the features of our patients with a control group compromising of 105 non‐MM patients.ResultsAmong the 35 confirmed cases of MM, with an average age of 61 years, 9 (25.7%) were female, and 26 (74.3%) were male. During our assessment, 12 patients had already died, with a mean time of 11.26 months post‐diagnosis. Our findings revealed a higher prevalence of MM among housekeepers and employees of oil companies. In comparison to the control group, individuals with occupational exposure and those residing near refinery locations were at a heightened risk of developing MM. However, based on regression analysis, only occupations associated with refineries exhibited a significant correlation with MM (p = 0.028; OR: 14.602; 95% CI: 1.328–160.499).ConclusionBoth occupational and para‐occupational exposure demonstrated a significant correlation with MM, whereas our regression analysis did not affirm geographical and environmental factors as contributors to MM. Despite the industry's prohibition of direct asbestos usage, the persistent existence of asbestos particles in the environment for decades, coupled with the long latency period of MM, warrants further investigation. Health authorities and policymakers should recognize this potential hazard, prompting an enhancement of early detection within at‐risk groups.
COVID‐19 vaccination in patients with multiple sclerosis: what you need to know – a review
Authors: Mahmoudi Farhad , Mirmosayyeb Omid , Shaabani Elnaz , Ghaffary Elham Moases , Nelson Flavia 
Published: October 2024

AbstractBackgroundThe appearance of severe acute respiratory syndrome Coronavirus 2 (SARS‐CoV‐2) initiated the COVID‐19 pandemic, resulting in millions of confirmed cases and numerous fatalities. In response, rapid vaccine development efforts were launched to mitigate the pandemic's impact. Despite the high efficacy of COVID‐19 vaccines, they are also associated with several common side effects/complications, some of them specific to the multiple sclerosis population. Our goal is to review various types of COVID‐19 vaccines, assessing their efficacy, adverse events, their association with an MS relapse following vaccination, and the influence of disease modifying therapies (DMTs) on vaccines’ efficacy.MethodsThe review was based on a database search that included PubMed/Medline, Embase, Scopus, and the Web of Science conducted from January 2020 to July 2024 using the following MeSH terms: MS, COVID‐19, COVID‐19 vaccination, vaccine side effects, and vaccine hesitancy.ResultsReceiving any type of COVID‐19 vaccine is a safer and more reliable approach to building immunity compared to becoming infected with the virus. Complications tend to be mild to moderate, occasionally severe. DMTs could affect the humoral response to the COVID‐19 vaccine. Among all DMTs, a notable reduction in the humoral response has been observed in patients who received anti‐CD20 and sphingosine‐1‐phosphate (S1P) receptor modulator drugs after their COVID‐19 vaccination.ConclusionDespite certain drawbacks, the benefits of the COVID‐19 vaccine significantly outweigh the associated risks, making it a recommended course of action for people with multiple sclerosis (pwMS). However, physicians need to be mindful of potential complications especially in patients undergoing anti CD20 and manage them appropriately.
Spatial analysis of risk factors related to colorectal cancer in Iran: An ecological study
Authors: Montaseri Zahra , Kargar Hossein , Sharafi Mehdi , Afrashteh Sima 
Published: October 2024

AbstractBackground and aimsColorectal cancer is the third most common cancer worldwide, accounting for 10% of cancer deaths. Therefore, this study was performed with the aim of spatial analysis of risk factors for colorectal cancer in Iran.MethodThis study was conducted ecologically using STEPS information (The WHO Stepwise Approach to NCD Risk Factor Surveillance) in Iran. To analyze the data, the researcher used cluster analysis and Geographically Weighted Regression methods with the help of ArcGIS version 10.ResultsThe results of OLS analysis showed that there was a significant relationship between tobacco consumption (B = 0.571, p‐value = 0.044) and smoking (B = 0.772, p‐value = 0.010) and the incidence of colon cancer (CC). There was also a significant relationship between abdominal obesity and the incidence of rectal cancer (RC) (B = 0.061, p‐value = 0.027).ConclusionThis study showed that (CC) high‐risk areas are located in central and northern parts of Iran, and the significant risk factors related to CC and RC were found to be tobacco use, cigarette smoking, and abdominal obesity. These findings are helpful to inform policymakers to plan screening services to reduce CC and RC, especially in high‐risk populations.
“They can learn it through us”: Youth seeking racial justice through a community‐based book club
Authors: McConnaha Mary M. , Marciano Joanne E. , Brewer Brittany M. , Reine Johnson Lauren Elizabeth 
Published: October 2024

AbstractIn the summer of 2020, amidst state‐mandated social distancing and protests for racial justice, youth participating in an ongoing YPAR initiative sought to design and facilitate a book club for the residents of their subsidized housing community to increase community awareness of the Black Lives Matter movement. Through interviews, youth shared their plans to design and facilitate a book club differently than they had experienced in English classroom settings. Through the lenses of critical literacy and civic praxis, the youths' imaginings reveal a desire to talk about books that were relevant to their lives, involve discussions that were participant‐led and democratic, and lead to meaningful, tangible outcomes. Implications encourage teachers to re‐examine their classroom book club practices and consider ways to center student desires.
Partitioning the projective plane into two incidence‐rich parts
Authors: Nagy Zoltán Lóránt 
Published: October 2024

AbstractAn internal or friendly partition of a vertex set of a graph is a partition to two nonempty sets such that every vertex has at least as many neighbours in its own class as in the other one. Motivated by Diwan's existence proof on internal partitions of graphs with high girth, we give constructive proofs for the existence of internal partitions in the incidence graph of projective planes and discuss its geometric properties. In addition, we determine exactly the maximum possible difference between the sizes of the neighbour set in its own class and the neighbour set of the other class that can be attained for all vertices at the same time for the incidence graphs of Desarguesian planes of square order.
Spontaneous Complete Chorioamniotic Membrane Separation in a Fetus With Ileal Atresia and Umbilical Cord Ulcer: A Case Report
Authors: Goto Hiroyuki , Isohata Hitoshi , Yamazaki Yu , Sakai Kanako , Yoshimura Yoshihiro , Hattori Kyoko , Shimaoka Takao , Sekiguchi Kazuki , Onishi Yoko , Ochiai Daigo 
Published: October 2024

ABSTRACTSpontaneous complete chorioamniotic membrane separation (cCMS) is rare and associated with adverse perinatal outcomes, such as intrauterine fetal death. Herein, we present a case of spontaneous cCMS in a fetus with ileal atresia and umbilical cord ulcers. In our case, we detected spontaneous cCMS on ultrasonography at 35 weeks of gestation. On the same day, a female infant weighing 2134 g was delivered via cesarean section. Pathological examination of the placenta confirmed cCMS and umbilical cord ulcers. When cCMS is evident in late preterm infants, the fetus should be carefully monitored and considered for delivery.
Experimentally Elevated Levels of Testosterone Advance Daily Onset of Activity in Short‐Day Housed Male House Sparrows (Passer domesticus)
Authors: Galante Holland , Lane Samuel J. , Elderbrock Emily K. , Brown Geoffrey , Greives Timothy J. 
Published: October 2024

ABSTRACTSeasonal changes in sleep/wake cycles and behaviors related to reproduction often co‐occur with seasonal fluctuations in sex hormones. Experimental studies have established that fluctuations in circulating testosterone mediate circadian rhythms. However, most studies are performed under constant lighting conditions and fail to investigate the effects of testosterone on the phenotypic output of circadian rhythms, that is, chronotype (daily activity patterns under light:dark cycles). Here, we experimentally elevated testosterone with implants during short nonbreeding daylengths in male house sparrows (Passer domesticus) to test if observed seasonal changes in chronotype are directly in response to photoperiod or to testosterone. We fitted individuals with accelerometers to track activity across treatment periods. Birds experienced three treatments periods: short day photoperiods before manipulation (SD), followed by testosterone implants while still on short days (SD + T). Implants were then removed. After a decrease in cloacal protuberance size, an indicator of low testosterone levels, birds were then photostimulated on long days (LD). Blood samples were collected at night, when testosterone peaks, to compare testosterone levels to daily onset/offset activity for experimental periods. Our results indicate that experimentally elevated testosterone under short nonbreeding photoperiods significantly advanced daily onset of activity and total daily activity relative to daylength. This suggests that testosterone, independent of photoperiod, is responsible for seasonal shifts in chronotypes and daily activity rhythms. These findings suggest that sex steroid hormone actions regulate timing of daily behaviors, likely coordinating expression of reproductive behaviors to appropriate times of the day.