bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sosialisasi Literasi Infomasi Kesehatan Bagi Ibu Rumah Tangga Sebagai Upaya Pencegahan Stunting Di Wetan Kota Kab. Garut
Authors: Suminar Jenny Ratna , Arifin Hadi Suprapto , Fuady Ikhsan , Prasanti Ditha , Aisha Sarah 
Published: September 2024

Stunting mencerminkan kondisi gagal tumbuh pada anak balita (bawah 5 tahun) akibat kekurangan gizi kronis, sehingga anak menjadi terlalu pendek untuk usianya. Stunting dapat menimbulkan dampak serius baik mikro (individu) maupun makro (masyarakat). Kabupaten garut merupakan salah satu kabupaten dengan tingkat prevelensi stunting tertinggi di Jawa Barat sebesar 43 persen. Tingginya angka prevelensi stunting ini tidak lepas dari pengetahuan dan sikap masyarkat (ibu muda) yang rendah tentang penting pencegahan stunting. Rendahnya pengetahuan ibu muda di Kabupaten Garut tidak lepas dari rendahnya literas tentang pola hidup sehat dan pencegahan stunting. Metode Pengabdian pada masyarkaat ini dilakukan dengan beberapa kegiatan yang terdiri dari metode komunikasi bermedia dengan penayangan materi â€œsosialiasi literasi, metode ceramah, metode interaktif dan evaluasi metode pre test dan post test. Hasil pengabdian menunjukkan bahwa peserta pelatihan memiliki pemahaman dan literasi yang rendah dalam pencegahan stunting, kurang memahami factor penyebab stunting. Kegiatan pengabdian ini meningkatkan atau melakukan penguatan terhadap pengetahuan, sikap dan literasi individu/ibu muda dalam pencegahan stunting. Hasil evaluasi menunjukan adanya perubahan pengetahuan, dan sikap, serta antusiasme ibu dalam pencegahan stunting.
Edukasi Kesehatan dan Upaya Peningkatkan Imunitas Tubuh dalam Rangka Pencegahan Covid-19 di Desa Kedinding Sidoarjo
Authors: Ningsih Wahyu , Qoiriyah Dwi Nur , Ervina Yusanti , Susilawati Yosi Nur , Rizki Allifa Hanna , Ngibad Khoirul 
Published: September 2024

The purpose of the community service program for the KKN (Kuliah Kerja Nyata) scheme is to organize health education during the Covid-19 pandemic and make efforts to increase body immunity in the context of preventing Covid-19 in RT 10 RW 03 Gebang Hamlet, Kedinding Village, Tarik District. There are 3 methods of community service activity program, namely: 1) making and distributing herbal herbs, 2) distributing masks, and 3) making videos about how to make hand sanitizers. This community service can have an impact in the form of increasing partner knowledge regarding Covid-19, how to make turmeric herbs, the importance of maintaining distance, and wearing masks.
Penerapan Media Pembelajaran Aplikasi ID (Inggris â€“ Diniyah) Sebagai Upaya Peningkatan Minat Belajar Siswa SD Negeri Rejosopinggir
Authors: Fadhli Khotim , Sholicha Nadyatus Nur , Sahroni Sahroni , Chasanah Uswatun , Anandita Septian Ragil 
Published: September 2024

Kegiatan pengabdian kepada masyarakat dilaksanakan untuk meningkatkan minat belajar siswa pada tingkat sekolah dasar melalui pemanfaatan aplikasi yang dibuat sebagai teknologi tepat guna. Mitra dalam pengabdian kepada masyarakat ini adalah Sekolah Dasar (SD) Negeri Rejosopinggir yang merupakan salah satu sekolah di Dusun Jatimenok Desa Rejosopinggir Kecamatan Tembelang Kabupaten Jombang. Kendala yang dihadapi mitra diantaranya adalah kurangnya tenaga pendidik sehingga masih ada pelajaran dasar yang belum diajarkan seperti pelajaran bahasa inggris, dan proses belajar masih belum banyak memanfaatkan teknologi sebagai media dalam belajar karena kurangnya pemahaman guru dalam memanfaatkan teknologi.
Pelaksanaan kegiatan pengabdian kepada masyarakat untuk pengenalan teknologi tepat guna yang dibuat dengan melibatkan Guru dan Siswa SD. Media pembelajaran yang dibuat dalam bentuk aplikasi ID (Inggris - Diniyah) diharapkan meningkatkan minat belajar siswa karena dalam aplikasi ID tersebut sudah didesain beberapa tampilan yang menjelaskan materi dilengkapi dengan gambar dan audio, sehingga siswa lebih senang untuk belajar dan memahami materi pelajaran.
Simpulan hasil pengabdian masyarakat yakni penerapan media pembelajaran aplikasi ID (Inggris â€“ Diniyah) berbasis android; pertama, memberikan tambahan wawasan dan pengetahuan mengenai belajar dengan mudah, menarik, dan menyenangkan. Kedua, menumbuhkan minat belajar siswa SD Negeri Rejosopinggir pada pelajaran Bahasa Inggris dan Keagamaan. Ketiga, membantu guru dalam menjelaskan materi dengan media yang lebih menarik
Chitosan Based Zinc and Copper Nanoparticles: Synthesis, Characterization and Antibacterial Activity Investigation
Authors: Islam Gazi Jahirul , Zannah Shaheda , Mohinuddin Md 
Published: September 2024

Chitosan biopolymer has been used as a key supporting material for the synthesis of metallic nanoparticles (MNPs) due to its exceptional qualities, which include good capping and stabilizing capabilities, biocompatibility, biodegradability, eco-friendliness, polycationic and non-toxicity. In this study, chitosan-based metal nanoparticles, such as copper nanoparticles (Chi-Cu NPs) and zinc nanoparticles (Chi-Zn NPs) have been synthesized, characterized and checked for their bacteriological properties. The solution casting method has been employed to produce metal nanoparticles based on chitosan. FTIR, TGA, and SEM analysis were employed to characterize the produced nanoparticles. The produced materials are nanomaterials with a size range of 1-100 nm, as demonstrated by the SEM photograph. The generated nanoparticles showed increased antimicrobial activity. Chi-Zn NPs have zones of inhibition of 38, 31, 30 and 39 and Chi-Cu NPs have zones of inhibition of 32, 36, 37 and 32 mm against Pseudomonas aeruginosa, Salmonella bovismorbificans, Salmonella typhi and Escherichia coli bacteria, respectively. Whereas the standard medication kanamycin have zones of inhibition 22, 22, 20 and 20 against those bacteria, respectively.
Journal of Engineering Science 15(1), 2024, 45-57
Menyelamatkan Anak dari Stunting dengan Pemberdayaan Keluarga Komprehensif
Authors: Febriati Listia Dwi , Muflih Muflih , Khasana Tri Mei , Widaryanti Rahayu , Lin Vivien , Alya Carolina 
Published: September 2024

Prevalensi kasus stunting sudah mulai mengalami penurunan, namun terjadi peningkatan kasus underweight dan wasting, jika hal ini tidak ditangani dengan baik maka akan menambah kasus stunting baru. Sebagian besar ibu tidak mengetahui status gizi anaknya termasuk dalam kategori underweight atau wasting. selain itu, sebagian besar ibu mengeluh anaknya susah makan, suka memilih makanan serta kurang mengkonsumsi makanan beragam termasuk protein hewani.. Tujuan kegiatan pengabdian ini adalah meningkatkan kemampuan keluarga untuk mencegah stunting dengan pemberdayaan keluarga secara komprehensif. Metode yang digunakan dalam kegiatan ini meliputi edukasi mengenai pemberian makanan pendamping air susu ibu (MP-ASI). Kegiatan ini dilaksanakan pada Selasa, 30 Juli 2024 dengan jumlah peserta 29 ibu yang memiliki balita underweight dan wasting. Setelah mengikuti kegiatan ibu lebih memahami status gizi anaknya dan mengetahui praktik pemberian makanan pendamping ASI yang tepat dan responsif.
Pendidikan Kesehatan Perilaku Hidup Bersih Sehat (PHBS) melalui Snake Ladder Game pada Kelompok Remaja
Authors: Kurniawati Lailaturohmah , Rofiiqoh Iyyana Al Fiatur , Hamidah Khusnun Adma 
Published: September 2024

Permasalahan yang sering muncul dikalangan remaja yaitu sikap dan pengetahuan remaja yang masih minim terkait perilaku hidup bersih sehat. Snake ladder game merupakan permainan berupa papan bidak yang familiar dikalangan anak-anak hingga remaja, sehingga dengan metode ini pesan preventif kesehatan PHBS bisa tersampaikan sesuai sasaran yaitu remaja. Tujuan dari pengabdian masyarakat untuk melatih terlaksananya Perilaku Hidup Bersih Sehat (PHBS) melalui Snake Ladder Game pada kelompok remaja Jebres, Surakarta. Metode pelaksanaan kegiatan ini terdiri dari 3 langkah dalam praktiknya: tahap persiapan, tahap pelaksanaan, dan tahap evaluasi. Hasil post test pengabdian masyarakat metode Snake Ladder Game pada perilaku hidup bersih dan sehat remaja dengan tingkat pengetahuan baik yaitu 92%. Pengabdian Masyarakat memberikan pengaruh terhadap peningkatan pengetahuan Pendidikan Kesehatan Perilaku Hidup Bersih Sehat (PHBS) melalui Snake Ladder Game.
Pelatihan Optimalisasi Resiliensi Mengajar Guru Sekolah Dasar dengan Strategi Modifikasi Perilaku Prososial di Kecamatan Kalipare Kabupaten Malang
Authors: Farida Ika Andrini , Utomo Hanggara Budi , Putri Raissa Dwifandra , Putri Syabiilah Azzahroh Widyatmoko , Priyatama Muhammad Aldwin 
Published: September 2024

Era disruptif saat ini memberikan tantangan bagi guru untuk berinovasi sehingga berdampak pada tingkat stres yang dialami oleh guru. Dukungan modifikasi perilaku prososial perlu diberikan agar guru dapat menjadi resilien. Tujuan pengabdian ini adalah mengeksplorasi efektivitas strategi modifikasi perilaku prososial untuk meningkatkan resiliensi mengajar di sekolah. Lokasi kegiatan pengabdian di SDN 1 Tempurejo Kabupaten Malang. Mitra pengabdian adalah guru sekolah dasar yang tergabung dalam KKG Gugus 7 Kecamatan Kalipare Kabupaten Malang sejumlah 48 orang. Metode yang digunakan adalah Participatory Action Research dna analisis data menggunakan uji beda t-test. Hasil kegiatan pengabdian kepada masyarakat adalah meningkatnya pemahaman pengetahuan guru SD mengenai cara menerapkan strategi modifikasi perilaku prososial untuk optimalisasi resiliensi mengajar. Hasil pemahaman resiliensi guru juga menunjukkan peningkatan setelah dilaksanakan edukasi dan sosialisasi yang dikonsep dalam bentuk seminar. Implikasi kegiatan ini adalah pengetahuan yang telah diperoleh guru sekolah dasar dapat diterapkan secara berkelanjutan dalam mengatasi berbagai permasalahan yang muncul dalam pekerjaan sehari-hari.
Analisis kemampuan berpikir kreatif matematis siswa kelas VIII SMP pada materi SPLDV di kota karawang
Authors: Wiwin Wiwin , Warmi Attin 
Published: September 2024

Tujuan penelitian ini untuk mengetahui kemampuan berpikir kreatif matematis siswa SMP pada materi SPLDV. Subjek pada penelitian ini yaitu 20 siswa kelas IX SMP Negeri yang ada di Kabupaten karawang. Metode yang digunakan pada penelitian ini adalah dengan metode penelitian deskriptif dengan pendekatan kualitatif yang mana tujuannya untuk mendeskripsikan atau menganalisis kemampuan berpikir kreatif matematis siswa dalam mengerjakan soal kemampuan berpikir kreatif pada materi SPLDV. Instrumen yang digunakan pada penelitian ini yaitu instrumen tes kemampuan berpikir kreatif matematis, Proses pelaksanaannya terdiri dari tiga langkah, yakni persiapan, pelaksanaan, dan analisis data. Pada tahap pelaksanaan siswa diberi soal tes kemampuan berpikir kreatif matematis yang terdiri dari 4 soal dengan aspek kemampuan berpikir kreatif matematis yang digunakan adalah Fluency, Flexibility, Elaborasi dan Originality. Hasil dari penelitian ini yaitu kemampuan berpikir kreatif matematis pada materi SPLDV siswa SMP di salah satu SMP yang tepatnya ada di Kabupaten Karawang berada dalam kategori sedang. Dengan jawaban siswa tidak mampu menghasilkan ide ide baru, dan siswa kurang mampu mengembangkan ide ide atau gagasan, kesimpulan dari penelitian ini dapat kita lihat dari indikator indikator kemampuan berpikir kreatif matematis siswa kurang mampu berpikir originality dan berpikir elaboration.
Mechanically durable tri-composite polyamide 6/hematite nanoparticle/tetra-n-butylammonium bromide (PA6/α-Fe2O3/TBAB) nanofiber based membranes for phosphate remediation
Authors: Choi Yun Young , Hanh To Dung Thi , Kim Sewoon , Cwiertny David M. , Myung Nosang V. 
Published: September 2024

Essential properties for a Point of Use (POU) water filter include maintaining high removal capacity and rate, with excellent mechanical properties to withstand pressure drop. Herein, mechanically robust tri-composite polyamide 6/iron oxide nanoparticles/tetra-n-butylammonium bromide (PA6/α-Fe2O3/TBAB) nanofiber composite membranes were electrospun for phosphate (P) remediation, where the diameter and composition were tuned by controlling solution compositions and electrospinning conditions. Tri-composite composition and morphology affect phosphate uptake where the adsorption capacity followed Langmuir isotherm whereas the adsorption kinetics followed pseudo second order behavior. Mechanical properties (i.e., Young’s Modulus (E) and toughness) were significantly influenced by the composition and morphology of the tri-composite, as well. Although additional TBAB and iron oxide decreased toughness, there are optimum composition ranges which resulted in maximum Young’s Modulus. Of the synthesized nanofiber membranes, PA6/α-Fe2O3/TBAB nanofibers with 17% α-Fe2O3 and 2% TBAB showed excellent phosphate uptake capacity [i.e., 8.9 mg/g (52 mg of P/g of α-Fe2O3)] while it is bendable, stretchable, and able to plastically deform without fracturing (i.e., Young’s modulus of 2.06 × 108 Pa and Toughness of 1.35 × 106 J m−3). With concerns over the impact of P on water resources and the long-term availability of limited P resources, this tri-composite membrane is well suited for applications in both wastewater treatment and resource recovery.
The association of common autoimmune diseases with autoimmune thyroiditis: a two-sample Mendelian randomization study
Authors: Zhang Kaiyuan , Luo Ziyue , Wang Xinchang 
Published: September 2024

ObjectiveNumerous observational and retrospective studies have demonstrated an association between Autoimmune Thyroiditis (AIT) and various systemic Autoimmune Diseases (AIDs). However, the causal relationship between them remains uncertain. This study aims to investigate the causal link between AIT and diverse types of AIDs utilizing the Mendelian Randomization (MR) method.MethodWe assessed the causal relationship between AIT and eight prevalent AIDs. Summary statistics from genome-wide association studies (GWAS) were sourced from the FinnGen biobank and IEU Open GWAS database. Two-sample MR analyses were conducted, with the primary statistical approach being the Inverse Variance Weighting (IVW) method. This was complemented by a series of sensitivity analyses, and the robustness of the findings was evaluated through the estimation of heterogeneity and pleiotropy.ResultsWhen AIT was considered as the outcome, MR evidence suggested an association between Rheumatoid arthritis (RA), Type 1 diabetes (T1D), and Systemic lupus erythematosus (SLE) with AIT. Utilizing the Inverse Variance Weighting (IVW) method, we observed an increased risk of AIT with exposure to RA (P = 0.024, OR=1.25; 95% CI = 1.03, 1.52), T1D (P &lt; 0.001, OR=1.27 95% CI = 1.11,1.46), and SLE (P = 0.037, OR=1.14; 95% CI = 1.04,1.26). Conversely, no significant genetic causal relationship with AIT was found for Sjögren’s syndrome (SS), Ankylosing Spondylitis (AS), Multiple sclerosis (MS), Crohn’s disease (CD), and Ulcerative colitis (UC).ConclusionThis study identified RA, T1D, and SLE as triggering factors for AIT. The incidence rate of AIT in patients with RA, T1D, and SLE may be higher than that in the general population. Therefore, individuals with these three diseases should undergo regular monitoring of thyroid-related indicators.
Prokinetic effect of erythromycin in the management of gastroparesis in critically ill patients—our experience and literature review
Authors: Szczupak Mateusz , Jankowska Magdalena , Jankowski Bartłomiej , Wierzchowska Jolanta , Kobak Jacek , Szczupak Paweł , Kosydar-Bochenek Justyna , Krupa-Nurcek Sabina 
Published: September 2024

IntroductionGastroparesis is a disorder characterized by impaired gastric emptying and the accumulation of food in the intestines without any clear mechanical cause. Gastroparesis in critical care patients is a prevalent issue in the intensive care unit. The disruption of normal gastrointestinal motility in critically ill patients is linked to a significant risk of intolerance to enteral feeding, colonization of the gastrointestinal tract with pathogenic bacterial strains, increased permeability of the intestinal wall, translocation of the intestinal microbiota, leading to progressive malnutrition, and potential development of bacterial infection.Materials and methodsThe literature was reviewed to assess the benefits and risks associated with the use of this medication.AimThe aim of the study was to treat the symptoms of gastroparesis and stimulate gastrointestinal motility. Consequently, the aim was to reduce the amount of backed-up food content in the stomach, accelerate gastrointestinal motility, and return to intestinal feeding.ResultsGastroparesis is a frequent issue among patients in the intensive care unit. Critical illness can lead to gastrointestinal motility disorders, causing slowed gastric emptying. This increases the risk of problems such as intolerance to enteral feeding, regurgitation, and aspiration of gastrointestinal contents into the respiratory tract, as well as colonization of the gastrointestinal tract by pathogens. Over time, impaired intestinal absorption can result in malnutrition, necessitating the initiation of parenteral nutrition.ConclusionAfter analysis of the literature and published scientific reports, as well as considering their own research, it is evident that erythromycin, as a prokinetic drug, effectively enhances gastrointestinal motility. This contributes to stimulating gastric emptying in critically ill patients with gastroparesis who are hospitalized in an intensive care unit. The use of erythromycin in combination with metoclopramide and/or itopride hydrochloride allows for a synergistic effect, leading to the quickest possible return to enteral feeding.
Machine learning-based prediction of early neurological deterioration after intravenous thrombolysis for stroke: insights from a large multicenter study
Authors: Wen Rui , Wang Miaoran , Bian Wei , Zhu Haoyue , Xiao Ying , Zeng Jing , He Qian , Wang Yu , Liu Xiaoqing , Shi Yangdi , Zhang Linzhi , Hong Zhe , Xu Bing 
Published: September 2024

BackgroundThis investigation seeks to ascertain the efficacy of various machine learning models in forecasting early neurological deterioration (END) following thrombolysis in patients with acute ischemic stroke (AIS).MethodsEmploying data from the Shenyang Stroke Emergency Map database, this multicenter study compiled information on 7,570 AIS patients from 29 comprehensive hospitals who received thrombolytic therapy between January 2019 and December 2021. An independent testing cohort was constituted from 2,046 patients at the First People’s Hospital of Shenyang. The dataset incorporated 15 pertinent clinical and therapeutic variables. The principal outcome assessed was the occurrence of END post-thrombolysis. Model development was executed using an 80/20 split for training and internal validation, employing classifiers like logistic regression with lasso regularization (lasso regression), support vector machine (SVM), random forest (RF), gradient-boosted decision tree (GBDT), and multi-layer perceptron (MLP). The model with the highest area under the curve (AUC) was utilized to delineate feature significance.ResultsBaseline characteristics showed variability in END incidence between the training (n = 7,570; END incidence 22%) and external validation cohorts (n = 2,046; END incidence 10%; p &lt; 0.001). Notably, all machine learning models demonstrated superior AUC values compared to the reference model, indicating their enhanced predictive capacity. The lasso regression model achieved the highest AUC at 0.829 (95% CI: 0.799–0.86; p &lt; 0.001), closely followed by the MLP model with an AUC of 0.828 (95% CI: 0.799–0.858; p &lt; 0.001). The SVM, RF, and GBDT models also showed commendable AUCs of 0.753, 0.797, and 0.774, respectively. Decision curve analysis revealed that the SVM and MLP models demonstrated a high net benefit. Feature importance analysis emphasized “Onset To Needle Time” and “Admission NIHSS Score” as significant predictors.ConclusionOur research establishes the MLP and lasso regression as robust tools for predicting early neurological deterioration in acute ischemic stroke patients following thrombolysis. Their superior predictive accuracy, compared to traditional models, highlights the significant potential of machine learning approaches in refining prognosis and enhancing clinical decisions in stroke care management. This advancement paves the way for more tailored therapeutic strategies, ultimately aiming to improve patient outcomes in clinical practice.
8-weeks aerobic exercise ameliorates cognitive deficit and mitigates ferroptosis triggered by iron overload in the prefrontal cortex of APPSwe/PSEN1dE9 mice through Xc−/GPx4 pathway
Authors: Li Chaoyang , Cui Kaiyin , Zhu Xinyuan , Wang Shufan , Yang Qing , Fang Guoliang 
Published: September 2024

BackgroundAlzheimer’s disease (AD) is a degenerative disorder of the central nervous system characterized by notable pathological features such as neurofibrillary tangles and amyloid beta deposition. Additionally, the significant iron accumulation in the brain is another important pathological hallmark of AD. Exercise can play a positive role in ameliorating AD, but the mechanism is unclear. The purpose of the study is to explore the effect of regular aerobic exercise iron homeostasis and lipid antioxidant pathway regarding ferroptosis in the prefrontal cortex (PFC) of APPSwe/PSEN1dE9 (APP/PS1) mice.MethodsEighty 6-month-old C57BL/6 J and APP/PS1 mice were divided equally into 8-weeks aerobic exercise groups and sedentary groups. Subsequently, Y-maze, Morris water maze test, iron ion detection by probe, Western Blot, ELISA, RT-qPCR, HE, Nissle, Prussian Blue, IHC, IF, and FJ-C staining experiments were conducted to quantitatively assess the behavioral performance, iron levels, iron-metabolism-related proteins, lipid antioxidant-related proteins and morphology in each group of mice.ResultsIn APP/PS1 mice, the increase in heme input proteins and heme oxygenase lead to the elevated levels of free iron in the PFC. The decrease in ferritin content by ferritin autophagy fails to meet the storage needs for excess free iron within the nerve cells. Ultimately, the increase of free ferrous iron triggers the Fenton reaction, may lead to ferroptosis and resulting in cognitive impairment in APP/PS1 mice. However, 8-weeks aerobic exercise induce upregulation of the Xc−/GPx4 pathway, which can reverse the lipid peroxidation process, thereby inhibiting ferroptosis in APP/PS1 mice.Conclusion8 weeks aerobic exercise can improve learning and memory abilities in AD, upregulate GPx4/Xc− pathway in PFC to reduce ferroptosis induced by AD.