bluuebunny/crossref_metadata_2025_split huggingface dataset:
Veno-Venous Extracorporeal Membrane Oxygenation in COVID-19-Associated ARDS: Predictors of Mortality
Authors: Mikaelyan K. A. , Petrova M. A. , Filimonova E. V. , Bazanovic S. A. 
Published: September 2024

The aim of the study was to identify factors associated with hospital mortality in patients with COVID-19associated acute respiratory distress syndrome (ARDS) receiving veno-venous extracorporeal membrane oxygenation (VV-ECMO).Materials and methods. The retrospective study included data from the medical records of 123 patients treated in the intensive care unit (ICU) № 7 of the City Clinical Hospital № 52 of Moscow Department of Health. ECMO was initiated in all patients for respiratory indications according to current recommendations. A number of factors potentially associated with mortality were systematized and analyzed. Statistical processing to identify predictors of death included univariate analysis and calculation of odds ratio (OR), ROC analysis with calculation of area under the ROC curve (AUROC).Results. The resulting mortality rate was 87% (107/123), 11% (14/107) of all deaths occurred after weaning from ECMO. High VV-ECMO ﬂow, delayed initiation of mechanical ventilation and ECMO therapy, and low pH at the time of ECMO initiation were identiﬁed as independent predictors of death in the study group. Low median albumin concentration and prolonged use of vasopressors were identiﬁed as predictors of death within 28 days of initiation of VV-ECMO. Development of acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT), septic shock and its recurrences, and the use of extracorporeal blood puriﬁcation therapy for septic shock were found to be predictors of death during VV-ECMO therapy.Conclusion. High-ﬂow VV-ECMO regimen, delayed initiation of mechanical ventilation and ECMO support, hypoalbuminemia, prolonged need for norepinephrine infusion, development of AKI requiring CRRT, septic shock occurrence and the number of its recurrences requiring extracorporeal blood puriﬁcation therapy during VV-ECMO support were identiﬁed as predictors of death in patients with COVID-19-associated ARDS after initiation of VV-ECMO therapy.
The Main Effects of the Original Oral Care Protocol Implementation in Patients on Invasive Mechanical Ventilation
Authors: Leyderman I. N. , Marichev A. О. , Kasherininov I. U. , Lesteva N. A. , Ponomareva A. D. , Sivcov A. О. , Ryabova D. V. , Nosenko M. М. , Ablesimov G. A. 
Published: September 2024

Respiratory infection is the most common nosocomial infection found in intensive care units (ICUs). Dental plaques and oral mucosa can be colonized by respiratory pathogens within a few days after tracheal intubation. Oral care plays an important role in reducing the incidence of ventilator-associated infections.Aim of the study. To evaluate clinical effectiveness of the original oral care protocol in ICU patients on invasive mechanical ventilation (IMV).Materials and Methods. A multicenter, open-label, randomized, prospective, controlled study was conducted in 55 surgical ICU patients on long-term mechanical ventilation. Oral care for patients in the study group (group 1, N=30) included brushing with disposable toothbrushes and rinsing with an aqueous solution of 0.05% chlorhexidine digluconate three times daily. In the control group (group 2, N=25), patients' oral care was performed twice a day using sterile cotton swabs soaked in 0.05% aqueous chlorhexidine digluconate solution. The results were statistically processed using IBM SPSS Statistics 21. The relative risk (RR) of events was calculated with a 95% confidence interval (95% CI). The 95% CIs for event density parameters such as incidence rate (IR) and incidence rate ratio (IRR) were calculated using the exact Poisson test.Results. The incidence of ventilator-associated pneumonia (VAP) was 13.6 cases [95% CI: 4.4; 31.7] per 1,000 ventilation days in group 1 and 23.6 cases [95% CI: 7.7; 55] per 1,000 ventilation days in group 2. The incidence of VAP was 1.74 times lower [95% CI: 0.4, 7.54] in group 1 vs. group 2 (P=0.398). The identity of oral and tracheal flora on day 7 was 20% in group 1 and 50% in group 2, RR=0.4, 95% CI: 0.165–0.973, P=0.037. Serum C-reactive protein levels were significantly lower in group 1 on day 7 of ventilation compared to group 2 (P=0.04).Conclusion. The original oral care protocol, based on toothbrushing 3 times daily with a set of disposable toothbrushes and 0.05% aqueous solution of chlorhexidine digluconate, is associated with a tendency to lower VAP incidence per 1000 days of ventilation, significantly lower similarity between oral and tracheal flora, and lower serum C-reactive protein levels on day 7 of IMV. Further research on various aspects of oral care in ICU patients is needed, especially in the absence of complete clinical guidelines and clearly effective strategies for the prevention of ventilator-associated infections.
The Eﬀect of Hemoadsorption with CytoSorb on Severe COVID-19 Complications
Authors: Rybalko A. S. , Galkina S. N. , Saryglar A. S. , Voronin A. V. , Rezyapova M. I. , Chaus N. I. , Perekhodov S. N. , Karpun N. A. 
Published: September 2024

The aim of the study was to assess the eﬀect of hemoadsorption with CytoSorb on the inﬂammatory response, respiratory failure, and mortality in patients with severe novel coronavirus infection.Materials and methods. A retrospective single-center cohort comparative study of hemoadsorbtion using the CytoSorb therapy included data from 124 COVID-19 ICU patients. Patients were divided into two groups: the study arm with hemoadsorption (group 1, N=93) and the control arm without hemoadsorption (group 2, N=31). Patients in group 1 had more severe respiratory failure at baseline, but were otherwise comparable to patients in group 2 in terms of clinical and demographic parameters.Results. After hemoadsorption, group 1 patients showed signiﬁcant improvement in 9 of 13 monitored clinical, instrumental, and laboratory parameters: fever (P=0.005), lactate dehydrogenase (LDH) (P<0.001), C-reactive protein (CRP) (P<0.001), and IL-6 (P<0.001) levels, as well as an increase in SpO₂/FiO₂ ratio (P=0.041), leukocyte count (P<0.001) and lymphocyte count (P=0.003), as well as no signiﬁcant changes in SOFA score (P=0.068). The only improvement seen in group 2 patients was a reduction in fever (P=0.003). Other signiﬁcant changes in group 2 were unfavorable, such as a decrease in SpO₂/FiO₂ ratio (P=0.002), an increase in inspiratory oxygen fraction FiO₂ (P=0.001), leukocyte count (P<0.05), LDH (P=0.038), procalcitonin (P<0.001), and IL-6 (P=0.005), as well as an increase in SOFA score from 3.0 to 7.0 (95%CI, 3.0–9.0) (P=0.001). The all-cause hospital mortality rate was 37,63% in group 1 and 74.20% in group 2.Conclusion. The use of hemoadsorption with CytoSorb as a pathogenetic therapy targeting the hyperinﬂammatory response in the management algorithm of ICU patients with severe COVID-19 complications resulted in resolution of the inﬂammatory response and respiratory failure, as well as a signiﬁcant reduction in mortality.
Change in occupational burnout measures in emergency medical service workers after a psychedelic experience induced by a single self-administered dose of psilocybin mushrooms
Authors: Machado Ferreira Ana Sofia , Martindale Sharon , Luke David 
Published: September 2024

AbstractBackground and AimsThis naturalistic mixed methods field study, aimed to assess the potential of a psilocybin induced experience, to help Emergency Medical Service Workers (EMSW) to address psychological and stress related symptoms stemming from a challenging working environment, known to contribute to occupational burnout (OB).MethodsThis exploration was conducted with an intentional sample of five participants, recruited through an online survey who self-administered a therapeutic dose of psilocybin mushrooms to manage psychological symptoms resulting from their work as EMSW, allowing the authors to assess the outcome. To measure the impact of the experience, changes in OB measures were assessed with psychometric instruments previously used in this population at three timepoints, before and after the session. The subjective impact of the psychedelic experience, through psychological insights and emotional breakthroughs, was also assessed, and two follow-up interviews were conducted to collect further data.ResultsThe results showed that, two weeks after the session, a visible improvement was noticed in several measures of pre-existent OB, that remained stable after two months. Additionally, most participants reported a strong subjective impact, that they perceived as fundamental for the positive outcome.ConclusionsAfter one therapeutic psylocibin session, several measures of OB showed an encouraging level of improvement and may constitute an important step towards finding alternative and innovative solutions to address high rates of psychological distress experienced by EMSWs, also benefiting the organization and the quality of patient care. The limitations and implications of the study and suggestions for future research are discussed.
Epidemiologic Profile and Clinical Outcomes of Patients with Pheochromocytoma in the University of the Philippines Philippine General Hospital (UP-PGH)
Authors: Hernandez Edrome , Jimeno Cecilia , Paz-Pacheco Elizabeth 
Published: September 2024

Objective. This study aims to describe the epidemiologic profile and determine the clinical outcomes of patients with pheochromocytoma at the University of the Philippines Philippine General Hospital (UP-PGH).
Methodology. We reviewed the medical records of 30 patients with histopathology-proven, clinical, and biochemical diagnosis of pheochromocytoma. Demographic, clinical characteristics, and clinical outcomes were collected for each patient.
Results. The median age at diagnosis of pheochromocytoma was 37.5 years (IQR 28-55) and the most common metabolic comorbidities were glucose intolerance (60%) and hypertriglyceridemia (23.3%). Majority of the patients were hypertensive (90%). Two third of the patients presented with classic features of pheochromocytoma while the remaining third presented as adrenal incidentaloma. Recurrence was found in 17% of subjects, who were significantly younger (25 years vs 46.5 years P = 0.0229), and had higher rates of bilateral pheochromocytoma (0 vs 75%), p = 0.002). Metastatic pheochromocytoma was found in 10% of the subjects.
Conclusion. Our study demonstrated that patients with pheochromocytoma in our setting exhibit great variability in terms of clinical behavior. Although majority of the patients presented with symptoms related to catecholamine excess, almost one-third of the patients were only incidentally discovered. Incidence of pheochromocytoma recurrence and metastasis in our setting are comparable with current available foreign studies.
Association of pulmonary function with functional capacity among middle-aged women
Authors: Vaish Hina , Sharma Digvijay 
Published: September 2024

INTRODUCTION: Age-related decline in pulmonary function and functional capacity is seen in adults. The menopausal process leads to a decline in pulmonary function and functional capacity which is essential in maintaining independence in daily life. OBJECTIVE: The present study aimed to explore the association of pulmonary function with functional capacity among middle-aged women. METHODS: One hundred and eight female participants aged 40–55 years were included in this cross-sectional study; depending on their menstrual history participants were classified as premenopausal and postmenopausal. After initial screening and assessment, six-minute walk test (6MWT) and pulmonary function (FEV1, FVC, FEV1/FVC) were recorded as per standardised guidelines. The mean and standard deviation for all continuous variables were calculated. Correlations were estimated using Pearson’s coefficient of correlation. A comparison of premenopausal and postmenopausal groups was done by independent t-test. A two-tailed p-value < 0.05 was considered statistically significant. RESULTS: There were significant differences in values of six-minute walk distance (6MWD) and pulmonary function values of pre and postmenopausal women (p < 0.05). The Pearson coefficient of correlation showed t significant association of FEV1, FVC and FEV1/FVC with 6MWD among middle-aged women. There was fair positive correlation of FEV1 (r = 0.391, p = 0.002) and FEV1/FVC (r = 0.395, p = 0.002) with 6MWD among postmenopausal women. CONCLUSION: There exists a fair positive correlation of pulmonary function with 6MWD among middle-aged women particularly postmenopausal women. Early screening of respiratory health and functional capacity should be initiated for middle-aged women as a preventive strategy.
Parental stress in childhood epilepsy
Authors: Bykovshchenko G. K. 
Published: September 2024

Background. Epilepsy is a common and persistent neurological disorder that typically affects children. In addition to the obvious physical and emotional outcomes for a child, epilepsy, like other chronic conditions, can have a profound impact on the well-being of family members. In order to comprehensively address and manage parental stress, it is essential to have a thorough understanding of the various factors involved.Objective: to determine the influence of parental stress on the course of epilepsy in children.Material and methods. A search for publications devoted to the study of parental stress in pediatric epilepsy in scientific databases PubMed/MEDLINE, Google Scholar, ScienceDirect, eLibrary identified 2670 articles. After the selection, 39 publications were included in the review.Results. There are a number of questionnaires that allow determining the level of parental stress: PSI, PSI-SF, PIP, IPES. They have shown their accuracy and have been validated in studies devoted to parental stress in parents of children with chronic diseases, including epilepsy. The relationship between the level of parental stress and the prognosis of epilepsy course, psychological state of children and the quality of life of parents was shown. The need for additional psychological support for parents of children with epilepsy was indicated. The feasibility of using biomarkers of brain damage in children as an additional tool for assessing the severity of parental stress was presented.Conclusion. Children with chronic conditions, such as epilepsy, and their families often face a number of interrelated problems. These include parental stress, difficulties in following treatment plans and adjusting to school, social discrimination. Despite the relevance of this issue, there are no large-scale, longitudinal studies examining stress in parents of children with epilepsy, so the relationship between epilepsy and parental stress is not fully understood. A collaborative approach is necessary, in which both the child and parents take responsibility for the treatment of the disease.
Гуманитарные аспекты проблемы понимания и оценки качества жизни в современном обществе
Authors: Колин Константин Константинович 
Published: September 2024

<p>Проведен анализ гуманитарных аспектов проблемы понимания и оценки качества жизни в современном обществе. Показано, что эта проблема выходит далеко за рамки проблематики социально-экономического развития и является ключевой в области обеспечения национальной и глобальной безопасности. Рассмотрены основные положения новой концепции оценки качества жизни в современном обществе, разработанной в Российской академии наук. Показаны ее принципиальные отличия от концепции ООН и международных рейтинговых агентств. Главное из них состоит в комплексном подходе с учетом гуманитарных аспектов качества жизни. При этом важнейшим показателем качества жизни является качество человеческого потенциала, который формируется в результате жизнедеятельности людей в конкретных условиях их обитания. Показана высокая значимость психологических факторов, которые являются определяющими для жизнеспособности человека. Главными из них являются безопасность жизни и уверенность в будущем.</p>
Álbum de História: Um relato de experiência em uma casa-lar em Novo Hamburgo - RS
Authors: Silveira Évelin Caroline da , Wendt Bruna 
Published: September 2024

O acolhimento institucional é uma medida de proteção provisória e excepcional direcionada a crianças e adolescentes cujos direitos foram ameaçados ou violados. Embora a reintegração da criança junto à sua família de origem ou extensa seja o objetivo primordial, nas situações em que isso não é possível, há a destituição do poder familiar e a criança é encaminhada para adoção. O processo de adoção exige preparação das famílias pretendentes e das crianças acolhidas. Este trabalho objetivou relatar a experiência de uma estagiária no processo de preparação para a adoção de uma criança acolhida em uma casa-lar no município de Novo Hamburgo, entre agosto/2022 e agosto/2023. O estágio foi orientado e supervisionado pela equipe técnica de gerência da Proteção Social Especial de Alta Complexidade do município, e por uma professora do curso de Psicologia da Faculdade IENH - Novo Hamburgo. As intervenções tiveram como inspiração o programa construído pelo Instituto Fazendo História, que propõe a produção de um álbum contando a história da criança desde o nascimento até o momento atual, o qual ela leva consigo após adoção ou na maioridade, para que possa seguir construindo. Foram planejados um total de sete encontros, cujos temas a serem trabalhados foram assim categorizados: sobre mim, sobre os outros e rotina. Esta experiência possibilitou aprendizados referentes aos processos de adoção, incluindo a busca por pretendentes no Sistema Nacional de Adoção, a abertura do Procedimento Preparatório para a Adoção e os efeitos psicológicos observados nas crianças e adotantes. Também possibilitou uma reflexão sobre o desacordo entre o tempo da justiça, que envolve a conclusão do processo de destituição, e o tempo subjetivo de cada criança, que engloba a elaboração do luto da perda da família biológica e abertura para um novo processo de filiação, permitindo contribuir na facilitação desse processo.
Uma análise dos processos de mudança e ordem social a partir das considerações de Parsons, Schutz e Garfinkel
Authors: Ferreira Marilaine Aparecida 
Published: September 2024

A dinâmica social, representada pela maneira como a vida social modifica-se, constitui um proeminente objeto da Sociologia. Neste ínterim, o presente trabalho aborda, a partir do pensamento de Parsons, Schutz e Garfinkel, as possibilidades de mudanças e permanências advindas das interações sociais. Ao se procurar os entrelaçamentos e diferenças entre os autores, demonstrou-se que a teoria dos sistemas sociais de Parsons centra-se nos processos de reprodução e de manutenção da ordem, por meio da integração e do controle, culminando na existência de uma sociedade mais resistente à mudança, enquanto Schutz valoriza a compreensão das experiências dos indivíduos como meio para a compreensão da própria sociedade, abrindo espaço para ressignificações e novos paradigmas. Por sua vez, Garfinkel, influenciado tanto pelos pensamentos de Schutz quanto pelos de Parsons, parte de uma análise das práticas concretas de interação para buscar compreender as regras que ordenam a vida social. Apesar de identificar a existência de padrões, Garfinkel, admite as alterações das experiências e das próprias regras a partir das práticas cotidianas.
CORPO BIOGRÁFICO FEMININO
Authors: De Souza Medina Bruna , Alvarenga Sena Venera Raquel 
Published: September 2024

O presente trabalho é um recorte da pesquisa de doutorado em Patrimônio Cultural e Sociedade. A tese pretende abordar o corpo biográfico de mulheres e o patrimônio cultural. O conceito de corpo biográfico desenvolvido por Josso (2012) entende o corpo como parte da narrativa de vida, pois é a partir do dele que se experimenta o ser-no-mundo. Assim, o corpo também é portador de memória e identidade, uma vez que estes conceitos se conectam. Entendendo que as construções sócio-históricas dos papéis de gênero colocam as mulheres em uma situação de vulnerabilidade em relação aos homens, principalmente as mulheres negras, na medida em que esses papéis operam como mecanismos de poder no patriarcado, visando disciplinar os corpos das mulheres e as formas em que elas devem ser-no-mundo, significando violências por vezes sutis - os padrões de beleza e corporais impostos as mulheres; as maneiras de se comportar; a forma de se sentar; o que vestir; os locais a frequentar; ou ainda violências explícitas chegando ao feminicídio. Considerando que o patriarcado se insere no âmbito social e cultural, uma vez que o patrimônio é vetor de memória e identidade, ele também pode operar nessa dinâmica de desigualdade de gênero. Sendo assim, esse artigo irá articular reflexões iniciais a cerca desses conceitos e suas relações, que posteriormente serão aprofundadas na tese de doutoramento, em fase inicial, em Patrimônio Cultural e Sociedade.
Immunological Response of Interleukin-6 on Cantang Hybrid Grouper (Ephinephelus sp.) By Induction Of Protein Brachionus sp.
Authors: Kumalaningrum Dwi Retna , Yanuhar Uun , Musa Mohammad , Martiningsih Nur Fauzi-yah 
Published: September 2024

This study examines the role of Brachionus sp protein on the interleukin-6 pro-inflammatory immune system in Cantang grouper infected with Viral Nervous Necrosis (VNN). The purpose of this study was to determine the protein content of Brachionus sp. which has the potential as an antivirus and to find out the benefits of Brachionus sp. on the expression of Interleukin-6 as an indicator of increased fish body defense system against VNN. Testing of Brachionus protein by injection at doses of 35 µl, 105 µl, and 170 µl /150 gram Cantang grouper. The results showed that the lowest decrease was at a dose of 105 µl/150-gram Cantang groupers. In addition, Brachionus sp. contains 3 protein bands with molecular weights of 122.73 kDa, 75.49 kDa, and 13.77 kDa.
Liver injury and recovery following radiation therapy for hepatocellular carcinoma: insights from functional liver imaging
Authors: Zaki Peter , Thonglert Kanokphorn , Apisarnthanarax Smith , Grassberger Clemens , Bowen Stephen R. , Tsai Joseph , Sham Jonathan G. , Chiang Bing-Hao , Nyflot Matthew J. 
Published: September 2024

Aim: A critical need for hepatocellular carcinoma (HCC) management is understanding how the liver recovers following radiotherapy (RT). We hypothesized that functional liver imaging with 99mTc-sulfur colloid (SC) SPECT/CT provides additional information on liver injury and recovery after RT compared to conventional imaging.
Methods: The liver function of patients with HCC was assessed using 99mTc-SC SPECT/CT imaging before and after definitive RT. The anatomical liver volume (ALV) was segmented on CT imaging. Liver function was measured as the total liver function (TLF) encompassing 30% of maximum SC uptake. Changes in ALV and TLF were compared to clinical characteristics.
Results: Of 31 patients with evaluable post-RT SC SPECT/CT scans (total of 32), 23 had pre-treatment Child-Pugh (CP)-A and 9 had CP-B/C scores. The median follow-up post-RT was 57 days. The median change in ALV was -1.7% with no significant difference between CP-A and CP-B/C patients (P = 0.26) or between short- (32-99 days) and long-term (271-1120 days) follow-up imaging groups (P = 0.28). The median change in TLF post-RT was -24% and was significantly different between short- and long-term groups (-39% vs. 2%, P = 0.001) and between CP-A and CP-B/C patients (-19% vs. -57%, P = 0.002). TLF significantly decreased following treatment at all radiation dose levels, with the decline correlating with the dose (P < 0.001).
Conclusion: Functional imaging provides additional information regarding liver injury and recovery following RT that conventional imaging cannot reveal. Patients with CP-A liver status showed less decline following RT and most had liver function near or above pre-treatment levels.