bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Visual–Acoustic Biofeedback Intervention for Residual Rhotic Errors: A Single-Subject Randomization Study
Authors: McAllister Byun Tara 
Published: April 2017

PurposeThis study documented the efficacy of visual–acoustic biofeedback intervention for residual rhotic errors, relative to a comparison condition involving traditional articulatory treatment. All participants received both treatments in a single-subject experimental design featuring alternating treatments with blocked randomization of sessions to treatment conditions.MethodSeven child and adolescent participants received 20 half-hour sessions of individual treatment over 10 weeks. Within each week, sessions were randomly assigned to feature traditional or biofeedback intervention. Perceptual accuracy of rhotic production was assessed in a blinded, randomized fashion. Each participant's response to the combined treatment package was evaluated by using effect sizes and visual inspection. Differences in the magnitude of response to traditional versus biofeedback intervention were measured with individual randomization tests.ResultsFour of 7 participants demonstrated a clinically meaningful response to the combined treatment package. Three of 7 participants showed a statistically significant difference between treatment conditions. In all 3 cases, the magnitude of within-session gains associated with biofeedback exceeded the gains associated with traditional treatment.ConclusionsThese results suggest that the inclusion of visual–acoustic biofeedback can enhance the efficacy of intervention for some individuals with residual rhotic errors. Further research is needed to understand which participants represent better or poorer candidates for biofeedback treatment.
Comprehending Comprehension: Selected Possibilities for Clinical Practice Within a Multidimensional Model
Authors: Wallach Geraldine P. , Ocampo Alaine 
Published: April 2017

Purpose
In this discussion as part of a response to Catts and Kamhi's “Prologue: Reading Comprehension Is Not a Single Activity” (2017), the authors provide selected examples from 4th-, 5th-, and 6th-grade texts to demonstrate, in agreement with Catts and Kamhi, that reading comprehension is a multifaceted and complex ability. The authors were asked to provide readers with evidence-based practices that lend support to applications of a multidimensional model of comprehension.

Method
We present examples from the reading comprehension literature that support the notion that reading is a complex set of abilities that include a reader's ability, especially background knowledge; the type of text the reader is being asked to comprehend; and the task or technique used in assessment or intervention paradigms. An intervention session from 6th grade serves to demonstrate how background knowledge, a text's demands, and tasks may come together in the real world as clinicians and educators aim to help students comprehend complex material.

Conclusions
The authors agree with the conceptual framework proposed by Catts and Kamhi that clinicians and educators should consider the multidimensional nature of reading comprehension (an interaction of reader, text, and task) when creating assessment and intervention programs. The authors might depart slightly by considering, more closely, those reading comprehension strategies that might facilitate comprehension across texts and tasks with an understanding of students' individual needs at different points in time.
Circularly polarised filtering monopole antenna based on miniaturised coupled filter
Authors: Cheng Wenbin , Li Dagang 
Published: April 2017

This Letter proposes a circularly polarised (CP) monopole antenna with filtering function, which is achieved by integrating a miniaturised coupled filter based on the bent‐loop resonators. The circular‐polarisation is obtained by using the falcate‐shaped patch as the radiation part, and the existence of the coupled filter in the feeding line would not affect the CP radiation performances. Both numerical simulation and experimental demonstration are performed for the designed CP filtering antenna, and good agreements are obtained. The designed antenna with dimension of 70 × 75 mm2 exhibits good frequency selective performances for the return loss, gain and axial ratio at 2.45 GHz with measured impedance matching bandwidth (|S11| < 10 dB) of 0.23 GHz. Such CP filtering antenna is a good candidate for the emerging application area, e.g. wearable biotelemetric devices.
Natural Products as Lead Compounds for Sodium Glucose Cotransporter (SGLT) Inhibitors
Authors: Blaschek Wolfgang 
Published: April 2017

AbstractGlucose homeostasis is maintained by antagonistic hormones such as insulin and glucagon as well as by regulation of glucose absorption, gluconeogenesis, biosynthesis and mobilization of glycogen, glucose consumption in all tissues and glomerular filtration, and reabsorption of glucose in the kidneys. Glucose enters or leaves cells mainly with the help of two membrane integrated transporters belonging either to the family of facilitative glucose transporters (GLUTs) or to the family of sodium glucose cotransporters (SGLTs). The intestinal glucose absorption by endothelial cells is managed by SGLT1, the transfer from them to the blood by GLUT2. In the kidney SGLT2 and SGLT1 are responsible for reabsorption of filtered glucose from the primary urine, and GLUT2 and GLUT1 enable the transport of glucose from epithelial cells back into the blood stream.The flavonoid phlorizin was isolated from the bark of apple trees and shown to cause glucosuria. Phlorizin is an inhibitor of SGLT1 and SGLT2. With phlorizin as lead compound, specific inhibitors of SGLT2 were developed in the last decade and some of them have been approved for treatment mainly of type 2 diabetes. Inhibition of SGLT2 eliminates excess glucose via the urine. In recent times, the dual SGLT1/SGLT2 inhibitory activity of phlorizin has served as a model for the development and testing of new drugs exhibiting both activities.Besides phlorizin, also some other flavonoids and especially flavonoid enriched plant extracts have been investigated for their potency to reduce postprandial blood glucose levels which can be helpful in the prevention and supplementary treatment especially of type 2 diabetes.
The Gospel according to Borges
Authors: Van Wyke Ben 
Published: April 2017

Abstract
Borges’s “Gospel According to Mark,” written 1,900 years after the first biblical Gospel by the same name, provides a compelling illustration of how translators always play a visible, creative role in the work they perform (even when they do not realize it or want this role). The characters’ interaction with the Bible is an ideal platform to explore some complex notions that stem from postmodern conceptions of translation, such as the complicated relationship established between translators, their translations and audience. Furthermore, it is worth noting that Mark had a considerable impact on two of the three other Gospel authors, and that the Bible has had immeasurable impact on the general interpretation and translation of texts around the world. Borges’s story may seem to portray an absurd misreading of the Mark, but I propose that this radical misreading is not altogether different from the millions of interactions with the texts that have been responsible for creating and disseminating the Bible. Through brief histories of both Mark and the Vulgate in tandem with Borges’s text, we can understand that millions of nameless translators, interpreters and scribes have been responsible for actually creating what is now, in a fragmented nature, the Bible.
A halo substructure in Gaia Data Release 1
Authors: Myeong G. C. , Evans N. W. , Belokurov V. , Koposov S. E. , Sanders J. L. 
Published: April 2017

Abstract
We identify a halo substructure in the Tycho Gaia Astrometric Solution (TGAS) data set, cross-matched with the Radial Velocity Experiment (RAVE-on) data release. After quality cuts, the stars with large radial action (JR &gt; 800 km s−1 kpc) are extracted. A subset of these stars is clustered in longitude and velocity and can be selected with further cuts. The 14 stars are centred on (X, Y, Z) ≈ (9.0, −1.0, −0.6) kpc and form a coherently moving structure in the halo with median (vR, vϕ, vz) = (167.33, 0.86, −94.85) km s−1. They are all metal-poor giants with median [Fe/H] = −0.83. To guard against the effects of distance errors, we compute spectrophotometric distances for 8 out of the 14 stars where this is possible. We find that six of the stars are still comoving. These six stars also have a much tighter [Fe/H] distribution ∼−0.7 with one exception ([Fe/H] = −2.12). We conclude that the existence of the comoving cluster is stable against changes in distance estimation and conjecture that this is the dissolving remnant of a globular cluster accreted long ago.
Cervical Spine Muscle-Tendon Unit Length Differences Between Neutral and Forward Head Postures: Biomechanical Study Using Human Cadaveric Specimens
Authors: Khayatzadeh Saeed , Kalmanson Olivia A. , Schuit Dale , Havey Robert M. , Voronov Leonard I. , Ghanayem Alexander J. , Patwardhan Avinash G. 
Published: April 2017

Abstract
Background. Forward head posture (FHP) may be associated with neck pain and poor health-related quality of life. Literature describes only qualitative muscle length changes associated with FHP.
Objective. The purpose of this study was to quantify how muscle-tendon unit lengths are altered when human cadaveric specimens are placed in alignments representing different severities of FHP.
Design. This biomechanical study used 13 fresh-frozen cadaveric cervical spine specimens (Occiput-T1, 54±15 y).
Methods. Specimens’ postural changes simulating increasing FHP severity while maintaining horizontal gaze were assessed. Specimen-specific anatomic models derived from computed tomography–based anatomic data were combined with postural data and specimen-specific anatomy of muscle attachment points to estimate the muscle length changes associated with FHP.
Results. Forward head posture was associated with flexion of the mid-lower cervical spine and extension of the upper cervical (sub-occipital) spine. Muscles that insert on the cervical spine and function as flexors (termed “cervical flexors”) as well as muscles that insert on the cranium and function as extensors (“occipital extensors”) shortened in FHP when compared to neutral posture. In contrast, muscles that insert on the cervical spine and function as extensors (“cervical extensors”) as well as muscles that insert on the cranium and function as flexors (“occipital flexors”) lengthened. The greatest shortening was seen in the major and minor rectus capitis posterior muscles. These muscles cross the Occiput-C2 segments, which exhibited extension to maintain horizontal gaze. The greatest lengthening was seen in posterior muscles crossing the C4-C6 segments, which exhibited the most flexion.
Limitations. This cadaver study did not incorporate the biomechanical influence of active musculature.
Conclusions. This study offers a novel way to quantify postural alignment and muscle length changes associated with FHP. Model predictions are consistent with qualitative descriptions in the literature.
Translating Research to Practice
Authors: Nelson Harriett , Mott Sandra 
Published: April 2017

Background:
A freestanding quaternary pediatric hospital in New England has been facilitating parents’ requests to take their child home or to a hospice facility from an Intensive Care Unit at end of life for the withdrawal of life sustaining measures for the past 16 years. However, knowledge of the aftermath of this decision was very limited. Before responding to a growing interest in making this service more available, an exploratory study was done to learn about the parents’ perceptions of the experience over time. We learned that the parents were very positive and highly recommending that pediatric palliative transports be made more available.

Objective:
The aim of this study was to describe the steps and rationale used to create a structured platform for pediatric palliative transports, drawing on findings from a previous study.

Outcomes:
To standardize the process, describe distinct responsibilities, and ensure quality and safety, an algorithm was created. The development of a checklist followed to enable the coordinator to follow the status of preparation for the transport. Empowered by parents’ requests and positive reflections, these transports are now offered more frequently to parents of children requiring care in an intensive care unit at end of life.
Evolution and revolution in cardiopulmonary resuscitation
Authors: Fowler Ray , Chang Mary P. , Idris Ahamed H. 
Published: April 2017

Purpose of review
To discuss the evolution of the technique of cardiopulmonary resuscitation (CPR), including presenting important research that has made substantial improvements in patient outcome.

Recent findings
The last half century has seen the arising of guidelines for performing CPR increasingly based on good scientific evidence. Improvements in the technique, including teaching citizens ‘compressions only CPR’, have simplified the process of rescue while improving survival.

Summary
Numerous scientific studies and the better understanding of physiology have contributed to enhanced outcomes while creating community-based systems of care.
Molecular Typing of Syphilis-Causing Strains Among Human Immunodeficiency Virus-Positive Patients in Antwerp, Belgium
Authors: Mikalová Lenka , Grillová Linda , Osbak Kara , Strouhal Michal , Kenyon Chris , Crucitti Tania , Šmajs David 
Published: April 2017

Abstract
Centers for Disease Control and Prevention and sequencing-based treponeme typing was used to analyze 72 blood samples, collected from human immunodeficiency virus and syphilis co-infected patients during 2014 to 2015 in Antwerp, Belgium. Twenty-nine (40.3%) isolates were polymerase chain reaction positive for Treponema pallidum, and all tested were macrolide-resistant. Four genotypes were identified by sequencing-based typing including two new genotypes, U4NR8 and SU9R8, whereas enhanced Centers for Disease Control and Prevention typing revealed 7 subtypes.
Assortativity and Mixing by Sexual Behaviors and Sociodemographic Characteristics in Young Adult Heterosexual Dating Partnerships
Authors: Malagón Talía , Burchell Ann , El-Zein Mariam , Tellier Pierre-Paul , Coutlée François , Franco Eduardo L. 
Published: April 2017

Background
Assortative sexual mixing, the tendency for individuals to choose partners with similar characteristics to themselves, may be an important contributor to the unequal distribution of sexually transmitted infections in populations. We analyzed the tendency for assortative mixing on demographic and sexual behaviors characteristics in newly formed young adults dating partnerships.

Methods
Women aged 18 to 24 years and their male sexual partners of no more than 6 months were recruited during 2005 to 2010 at universities in Montreal, Canada. New dating partners were also prospectively recruited during the 2-year follow-up. We used Spearman and Newman coefficients to examine correlations between partners' demographic characteristics and sexual behaviors, and multivariable logistic modeling to determine which characteristics were assortative.

Results
Participants in 502 recruited partnerships were assortative on age (Spearman P = 0.60), smoking behavior (P = 0.43), ethnicity (Newman coefficient=0.39), lifetime number of sexual partners (P = 0.36), sex partner acquisition rates (P = 0.22), gap length between partnerships (P = 0.20), and on whether they had concurrent partners (P = 0.33). Partners were assortative on number of lifetime partners, sexual partner acquisition rates, concurrency, and gap length between partnerships even after adjustment for demographic characteristics. Reported condom use was correlated between initial and subsequently recruited partners (P = 0.35). There was little correlation between the frequencies of vaginal/oral/digital/anal sex between subsequent partnerships.

Conclusions
Dating partnerships were substantially assortative on various sexual behaviors as well as demographic characteristics. Though not a representative population sample, our recruitment of relatively new partnerships reduces survivor bias inherent to cross-sectional surveys where stable long-term partnerships are more likely to be sampled.
Keeping an Eye on Chlamydia and Gonorrhea Conjunctivitis in Infants in the United States, 2010–2015
Authors: Kreisel Kristen , Weston Emily , Braxton Jim , Llata Eloisa , Torrone Elizabeth 
Published: April 2017

Abstract
Perinatal transmission of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) can result in conjunctivitis in infants. We examined national rates of reported CT/GC conjunctivitis among infants. Surveillance of these infections is heavily affected by the completeness of reported data on specimen source and age. Alternative data sources should be evaluated.
Evaluating the Effectiveness of Concurrent Review: Does It Improve Stroke Measure Results?
Authors: McGillivray Celia Gomes , Silver Brian 
Published: April 2017

Background:
Concurrent review is a quality improvement strategy in which patients are tracked from admission to discharge, and messages are communicated to the responsible physician when quality stroke measures have not been met. There is little research regarding interventions that might influence clinical practice patterns and improvement in compliance with core quality measures. This study sought to evaluate whether concurrent review implementation was associated with change in performance on stroke measure outcome data.

Methods:
Randomly selected charts from 2 hospitals (A and B) during 3 time periods were reviewed. In period 1, neither hospital had a process for concurrent review. In period 2, hospital A, where concurrent review was implemented, was compared with hospital B without this process. In period 3, both hospitals had the process of concurrent review. Information on baseline demographics, insurance status, and length of stay was collected, as well as stroke performance measures.

Results:
A total of 620 medical records were reviewed during the 3 time periods. Although the number of beds and annual stroke volume were higher at hospital B, patient characteristics were similar. During period 2, when hospital A implemented concurrent review and hospital B had not, a statistically significant higher compliance with performance in 7 stroke measures occurred in hospital A than in hospital B. In period 3, when both hospitals utilized concurrent review, no statistical significant differences occurred in 7 of the 10 stroke measures.

Conclusion:
Concurrent review is a quality improvement intervention that increases performance with stroke performance measures.
The Risk of Transplant Failure With HLA Mismatch in First Adult Kidney Allografts 2: Living Donors, Summary, Guide
Authors: Williams Robert C. , Opelz Gerhard , Weil E. Jennifer , McGarvey Chelsea J. , Chakkera Harini A. 
Published: April 2017

Background
Allografts from living donors survive longer than those from deceased donors but the role of HLA mismatching in living kidney donation is still in question. We examined the effect of HLA compatibility on kidney allograft survival from living donors by studying all first adult kidney transplants performed in the United States over 25 years.

Methods
Using the United Network for Organ Sharing data, we identified first kidney transplants between October 1, 1987, and December 31, 2013. Recipients were classified by their number of HLA mismatches and stratified by donor origin. Cox multivariate regression analyses adjusting for recipient and donor transplant characteristics were performed to determine impact of HLA compatibility on kidney allograft survival for all living donors and for living related and living unrelated subsets.

Results
There were 66 596 first adult transplants from living donors with 348 960 years of follow-up. We found a linear relationship between HLA mismatch and allograft survival. In adjusted analyses, among all living donors, 1 mismatch conferred a 44% higher risk, whereas 6 mismatches conferred a twofold higher risk of allograft failure. When using 0-mismatched full siblings as a reference, living-donor kidneys reduce the hazard of failure by approximately 34% when compared with deceased donors. Twenty-five years of transplant experience, stratified by donor source, was summarized and presented as a guide for allocation.

Conclusions
These data reinforce the importance of optimizing HLA matching to further improve survival in first adult kidney allografts in the future, especially in living unrelated donations, when possible.
Addressing the digital divide in contemporary biology: Lessons from teaching UNIX
Authors: Mangul Serghei , Martin Lana S. , Hoffmann Alexander , Pellegrini Matteo , Eskin Eleazar 
Published: April 2017

AbstractResearchers in the biomedical sciences increasingly rely on applications that lack a graphical interface and require inputting code that, such as UNIX. Scientists who are not trained in computer science face an enormous challenge in analyzing the high-throughput data their research groups generate. We present a training model for use of command-line tools when the learner has little to no prior knowledge of UNIX.
The odd one out:Arabidopsisreticulon20 has a role in lipid biosynthesis
Authors: Kriechbaumer Verena , Maneta-Peyret Lilly , Botchway Stanley W , Upson Jessica , Hughes Louise , Richardson Jake , Kittelmann Maike , Moreau Patrick , Hawes Chris 
Published: April 2017

AbstractThe family of reticulon proteins has been shown to be involved in a variety of functions in eukaryotic cells including tubulation of the endoplasmic reticulum (ER), formation of cell plates and primary plasmodesmata. Reticulons are integral ER membrane proteins characterised by a reticulon homology domain comprising four transmembrane domains which results in the reticulons sitting in the membrane in a W-topology. Here we report on a subgroup of reticulons with an extended N-terminal domain and in particular on arabidopsis reticulon 20. We show that reticulon 20 is located in a unique punctate pattern on the ER membrane. Its closest homologue reticulon 19 labels the whole ER. We show that mutants in RTN20 or RTN19, respectively, display a significant change in sterol composition in the roots indicating a role in lipid biosynthesis or regulation. A third homologue in this family - 3BETAHSD/D1- is localised to ER exit sites resulting in an intriguing location difference for the three proteins.