bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary patterns of adults in Italy: Results from the third Italian National Food Consumption Survey, INRAN-SCAI
Authors: Scarsi Nicolò , Pastorino Roberta , Savoia Cosimo , Raspolini Gian Marco , Pezzullo Angelo Maria , Boccia Stefania 
Published: October 2024

ABSTRACTBackground & objective.Diet is among the most significant modifiable risk factors for reducing the global burden of chronic diseases. This study aims to investigate the dietary patterns of adults in a large representative sample of the Italian population and to analyze these patterns according to sociodemographic characteristics.MethodsAdult participants of the third Italian National Food Consumption Survey (INRAN- SCAI 2005-06) were included. A total of 878 food items were classified into 24 pre-defined food groups using the FoodEx2 classification system. Dietary patterns were identified through principal component analysis, and Z-scores were calculated to assess adherence to these patterns. Associations between sociodemographic characteristics, energy intake, and dietary adherence scores were investigated using linear regression models.ResultsBased on data from 2,831 subjects (median age 47, IQR 35-60), five principal components (PCs) were retained, explaining 35.6% of the overall variance. PC1 was indicative of a high-fat diet, PC2 suggested a western eating behavior, PC3 represented a health-conscious lifestyle, PC4 can be characterized as an Italian traditional diet, and PC5 represented an unhealthy dietary pattern. According to Z-scores, 42.4% of our study cohort showed high adherence to at least one of the dietary patterns. Less healthy dietary patterns were more prevalent among males and individuals from northern Italian regions.ConclusionsOur results indicate a significant regional variation in terms of dietary pattern, mirroring the general trends of Italian eating habits of the last decades, characterized by a higher tendency towards a more westernized lifestyle. These findings underscore the importance of considering region-specific characteristics when designing future public health interventions and establishing national dietary guidelines.
ZNFX1 is a Novel Master Regulator in Epigenetically-induced Pathogen Mimicry and Inflammasome Signaling in Cancer
Authors: Stojanovic Lora , Abbotts Rachel , Tripathi Kaushlendra , Coon Collin M. , Rajendran Saranya , Farid Elnaz Abbasi , Hostetter Galen , Guarnieri Joseph W. , Wallace Douglas C. , Liu Sheng , Wan Jun , Calendo Gennaro , Marker Rebecca , Gohari Zahra , Inayatullah Mohammed M. A. , Tiwari Vijay K. , Kader Tanjina , Santagata Sandro , Drapkin Ronny , Kommoss Stefan , Pfisterer Jacobus , Konecny Gottfried E , Coopergard Ryan , Issa Jean-Pierre , Winterhoff Boris J. N. , Topper Michael J. , Sandusky George E. , Miller Kathy D. , Baylin Stephen B. , Nephew Kenneth P. , Rassool Feyruz V. 
Published: October 2024

AbstractDNA methyltransferase and poly(ADP-ribose) polymerase inhibitors (DNMTis, PARPis) induce a stimulator of interferon (IFN) genes (STING)-dependent pathogen mimicry response (PMR) in ovarian (OC) and other cancers. We now show that combining DNMTis and PARPis upregulates expression of a little-studied nucleic-acid sensor, NFX1-type zinc finger-containing 1 protein (ZNFX1). We demonstrate that ZNFX1 is a novel master regulator for PMR induction in mitochondria, serving as a gateway for STING-dependent PMR. In patient OC databases, high ZNFX1 expression levels correlate with advanced stage disease. ZNFX1 expression alone significantly correlates with an increase in overall survival in a phase 3 trial for therapy-resistant OC patients receiving bevacizumab in combination with chemotherapy. In correlative RNA-seq data, inflammasome signaling through ZNFX1 correlates with abnormal vasculogenesis. ZNFX1 controls PMR signaling through the mitochondria and may serve as a biomarker to facilitate offering personalized therapy in OC patients, highlighting the strong translational significance of our findings.Significance statementDNA methyltransferase and poly(ADP-ribose) polymerase inhibitors upregulate expression of a novel nucleic-acid sensor, ZNFX1 that serves as a mitochondrial gateway to STING-dependent interferon/inflammasome signaling with tumor suppressor properties in ovarian cancer.
Idiopathic Intracranial Hypertension and Cardiovascular Diseases Risk in the United Kingdom Women: An Obesity-Adjusted Risk Analysis Using Indirect Standardization
Authors: Azzam Ahmed Y. , Morsy Mahmoud M. , Ellabban Mohamed Hatem , Morsy Ahmed M. , Zahran Adham Adel , Nassar Mahmoud , Elsayed Omar S. , Elswedy Adam , Elamin Osman , Al Zomia Ahmed Saad , Abukhadijah Hana J. , Alotaibi Hammam A. , Atallah Oday , Azab Mohammed A. , Essibayi Muhammed Amir , Dmytriw Adam A. , Morsy Mohamed D. , Altschul David J. 
Published: October 2024

AbstractIntroductionIdiopathic intracranial hypertension (IIH) is associated with increased cardiovascular disease (CVD) risk, but the relative contributions of obesity versus IIH-specific factors remain unclear. This study aims to disentangle the effects of obesity and IIH on stroke and CVD risk, building upon previous research suggesting a two-fold increased risk of cardiovascular events in women with IIH compared to BMI-matched controls.MethodsWe conducted an obesity-adjusted risk analysis using Indirect Standardization analysis based on Adderley et al. study which utilized data from a cohort of 2,760 women with IIH and 27,125 matched healthy controls from The Health Improvement Network (THIN) database. We employed innovative statistical models to adjust for the confounding effects of obesity, estimating the risk of ischemic stroke and cardiovascular disease attributable to IIH independent of obesity. Four distinct models were used to elucidate the complex interrelationships between IIH, obesity, and CVD risk.ResultsOur analysis revealed that IIH confers additional cardiovascular risk beyond that attributed to obesity alone. Risk ratios for various cardiovascular outcomes were consistently elevated across models comparing IIH patients to controls within the same obesity strata. A striking synergistic effect between IIH and obesity was observed, with the composite CVD risk reaching a risk ratio of 6.19 (95% CI: 4.58-8.36, p<0.001) in obese IIH patients compared to non-obese controls.ConclusionsThis study provides compelling evidence for a nuanced relationship between IIH, obesity, and cardiovascular risk. IIH appears to confer substantial cardiovascular risk independent of obesity, necessitating a paradigm shift in IIH management to encompass comprehensive cardiovascular risk mitigation. Further research is needed to elucidate the underlying mechanisms and develop targeted interventions for this unique patient population.
Molecular Specification of Claustro-Amygdalar and Paleocortical Neurons and Connectivity
Authors: Kaur Navjot , Kovner Rothem , Gulden Forrest O. , Pletikos Mihovil , Andrijevic David , Zhu Tianjia , Silbereis John , Ma Shaojie , Salla Nikkita , Martin Xabier de , Klarić Thomas S. , Liu Yuting , Shibata Akemi , Franjic Daniel , Cho Hyesun , Yuen Matthew , Chatterjee Ipsita , Burke Megan , Esakkimuthu Devippriya , Moser Markus , Santpere Gabriel , Mineur Yann S. , Pattabiraman Kartik , Picciotto Marina R. , Huang Hao , Sestan Nenad 
Published: October 2024

AbstractThe ventropallial excitatory neurons (ExNs) in the claustro-amygdalar complex and piriform cortex (PIR; part of paleocortex) form crucial reciprocal connections with the prefrontal cortex (PFC), integrating cognitive and sensory information that result in adaptive behaviors. Early-life disruptions in these circuits are linked to neuropsychiatric disorders, highlighting the importance of understanding their development. Our study uncovers that transcription factors SOX4, SOX11, and TFAP2D play a pivotal role in the development, identity, and PFC connectivity of these neurons. Using mouse models, we demonstrate that the absence of transcription factors SOX4 and SOX11 in post-mitotic ExNs dramatically reduces the size of the basolateral amygdala complex (BLC), claustrum, and PIR. SOX4 and SOX11 control BLC formation through direct regulation ofTfap2dexpression. Cross-species analyses, including humans, identified conservedTfap2dexpression in developing ExNs of BLC, claustrum, paleocortex including PIR, and the associated transitional areas of the frontal, insular and temporal cortex. While the loss and haploinsufficiency ofTfap2dyield similar alterations in learned threat behaviors, differences emerge in the manifestation ofTfap2ddosage, particularly in terms of changes observed in BLC size and the connectivity pattern between the BLC and PFC. This underscores the significance ofTfap2ddosage in orchestrating developmental shifts in BLC-PFC connectivity and behavioral modifications reminiscent of symptoms of neuropsychiatric disorders. Together, these findings reveal key elements of a conserved gene regulatory network that shapes the development and function of crucial ventropallial ExNs and their PFC connectivity and offer insights into their evolution and alterations in neuropsychiatric disorders.
Ca2+-dependent vesicular and non-vesicular lipid transfer controls hypoosmotic plasma membrane expansion
Authors: Mu Baicong , Rutkowski David M. , Grenci Gianluca , Vavylonis Dimitrios , Zhang Dan 
Published: October 2024

SummaryRobust coordination of surface and volume changes is critical for cell integrity. Few studies have elucidated the plasma membrane (PM) remodeling events during cell surface and volume alteration, especially regarding PM sensing and its subsequent rearrangements. Here, using fission yeast protoplasts, we reveal a Ca2+-dependent mechanism for membrane addition that ensures PM integrity and allows its expansion during acute hypoosmotic cell swelling. We show that MscS-like mechanosensitive channels activated by PM tension control extracellular Ca2+influx, which triggers direct lipid transfer at endoplasmic reticulum (ER)-PM contact sites by conserved extended-synaptotagmins and accelerates exocytosis, enabling PM expansion necessary for osmotic equilibrium. Defects in any of these key events result in rapid protoplast rupture upon severe hypotonic shock. Our numerical simulations of hypoosmotic expansion further propose a cellular strategy that combines instantaneous non-vesicular lipid transfer with bulk exocytic membrane delivery to maintain PM integrity for dramatic cell surface/volume adaptation.
Intrinsic Diversity In Primary Cilia Revealed Through Spatial Proteomics
Authors: Hansen Jan N. , Sun Huangqingbo , Kahnert Konstantin , Westenius Eini , Johannesson Alexandra , Tzavlaki Kalliopi , Winsnes Casper , Pohjanen Emmie , Fall Jenny , Navarro Frederic Ballllosera , Bäckström Anna , Lindskog Cecilia , Johansson Fredric , von Feilitzen Kalle , Vega Angelica Delgado , Uhlén Mathias , Casals Anna Martinez , Mahdessian Diana , Lindstrand Anna , Axelsson Ulrika , Lundberg Emma 
Published: October 2024

AbstractPrimary cilia are a critical organelle found on most human cells, and their dysfunction is linked to hereditary ciliopathies with diverse symptoms. Despite their significance, the specific roles of cilia in different cell types remain poorly understood due to limitations in analyzing ciliary protein composition. We employed antibody-based spatial proteomics to expand the Human Protein Atlas to primary cilia. Our analysis identified the subciliary locations of 654 proteins across three cell lines, examining 110,844 individual cilia. We found that 67% of the ciliary proteome is cell-type specific, and 78% exhibited dynamically varied localization patterns, indicating that protein trafficking is crucial for ciliary function. Our findings portray cilia as dynamic sensors tuning their proteome to effectively sense the environment and compute cellular responses. We identified 71 novel cilia proteins and linked a genetic variant inCREB3to typical ciliopathy phenotypes. This open, spatial cilia atlas advances research on cilia and ciliopathies.
Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex
Authors: Sellitto Stefano , Caredio Davide , Bimbati Matteo , Mariutti Giovanni , Cerisoli Martina , Frick Lukas , Bouris Vangelis , Morales Carlos Omar Oueslati , Vena Dalila Laura , Neupane Sandesh , Baroni Federico , Ging Kathi , Yin Jiang-An , De Cecco Elena , Armani Andrea , Aguzzi Adriano 
Published: October 2024

AbstractHeterogeneous Nuclear Ribonucleoprotein K (hnRNP K) is a limiting factor for prion propagation. However, little is known about the function of hnRNP K except that it is essential to cell survival. Here, we performed a synthetic-viability CRISPR ablation screen to identify epistatic interactors ofHNRNPK. We found that deletion of Transcription Factor AP-2γ (TFAP2C) suppressed the death of hnRNP K-depleted LN-229 and U-251 MG cells, whereas its overexpression hypersensitized cells to hnRNP K loss.HNRNPKablation decreased cellular ATP, downregulated genes related to lipid and glucose metabolism, and enhanced autophagy. Co-occurrent deletion ofTFAP2Creversed these effects, restoring transcriptional balance and alleviating energy deficiency. We linkedHNRNPKandTFAP2Cinteraction to mTOR signaling, observing thatHNRNPKablation inhibited mTORC1 activity through downregulation of mTOR and Rptor, whileTFAP2Coverexpression enhanced mTORC1 downstream functions. In prion-infected cells,TFAP2Cactivation reduced prion levels and countered the increased prion propagation caused byHNRNPKsuppression. Short-term pharmacological inhibition of mTOR also elevated prion levels and partially mimicked the effects ofHNRNPKsilencing. Our study identifiesTFAP2Cas a genetic interactor ofHNRNPK, implicates their roles in mTOR metabolic regulation, and establishes a causative link between these activities and prion propagation.
Declaration of free sugars from fruits on food labels: a scoping review
Authors: Padovan Marina , Ares Gaston , Scapin Tailane , Kraemer Mariana Vieira dos Santos , Chaddad Maria Cecília Cury , Fernandes Ana Carolina , Bernardo Greyce Luci , Uggioni Paula Lazzarin , Pettigrew Simone , Proença Rossana Pacheco da Costa 
Published: October 2024

PurposeThe World Health Organization recommends limiting the intake of free sugars, which can be added to packaged foods and may appear on labels under different terms. The aim of this research was to analyse the evidence related to the declaration of free sugars from fruits on packaged food labels.Design/methodology/approachA scoping review was conducted following the recommendations of the Joanna Briggs Institute (JBI).FindingsTen eligible studies, conducted in seven countries, were included in this review. The percentage of packaged foods in which free sugars were identified ranged from 52.5 to 86.5%. In three studies, terms related to sugars were identified inductively by reading the entire ingredient list, whereas in the other studies sugars were identified by searching for a list of predefined terms. Studies differed in the definition of sugars and the terms used to identify them. Nine studies included fruit sugars within the terms used to identify free sugars. However, they lacked consistency in the types of fruit sugars considered and did not discuss their agreement with the adopted definitions of sugars.Originality/valueAs far as can be ascertained, this is the first review that addresses the declaration of free sugars from fruits on packaged food labels. Overall, there is a scarcity of literature focused on identifying and discussing the range of free sugars from fruits declared on food labels.
Statistical monitoring applied to data science in classification: continuous validation in predictive models
Authors: Bueno Carlos Renato , Sordan Juliano Endrigo , Oprime Pedro Carlos , Vicentin Damaris Chieregato , Condé Giovanni Cláudio Pinto 
Published: October 2024

PurposeThis study aims to analyze the performance of quality indices to continuously validate a predictive model focused on the control chart classification.Design/methodology/approachThe research method used analytical statistical methods to propose a classification model. The project science research concepts were integrated with the statistical process monitoring (SPM) concepts using the modeling methods applied in the data science (DS) area. For the integration development, SPM Phases I and II were associated, generating models with a structured data analysis process, creating a continuous validation approach.FindingsValidation was performed by simulation and analytical techniques applied to the Cohen’s Kappa index, supported by voluntary comparisons in the Matthews correlation coefficient (MCC) and the Youden index, generating prescriptive criteria for the classification. Kappa-based control charts performed well for m = 5 sample amounts and n = 500 sizes when Pe is less than 0.8. The simulations also showed that Kappa control requires fewer samples than the other indices studied.Originality/valueThe main contributions of this study to both theory and practitioners is summarized as follows: (1) it proposes DS and SPM integration; (2) it develops a tool for continuous predictive classification models validation; (3) it compares different indices for model quality, indicating their advantages and disadvantages; (4) it defines sampling criteria and procedure for SPM application considering the technique’s Phases I and II and (5) the validated approach serves as a basis for various analyses, enabling an objective comparison among all alternative designs.
Influence of employee job crafting in Chinese manufacturing enterprises on safety innovation performance: a moderated mediation model
Authors: Yang Jiaoping , Qi Ziru , Zhu Jianhua 
Published: October 2024

Purpose
The purpose of this paper is to explore the influence of employees’ job crafting on safety innovation performance through psychological empowerment and the moderation effects of employees’ mindfulness traits and job complexity on such impact.

Design/methodology/approach
This study conducted structure equation modeling to analyze data collected from 1,566 employees in 96 manufacturing enterprises in northern and central China.

Findings
Results showed that employees’ job crafting has a positive effect on safety innovation performance, partially through psychological empowerment, and that effect was moderated by employee mindfulness traits and job complexity.

Practical implications
Manufacturing enterprises should seek to promote employees’ job crafting behavior in the workplace, improve employees’ psychological empowerment and pay attention to mindfulness training for enterprise managers and employees, so as to reduce the probability of unsafe behavior.

Originality/value
This study reveals the underlying influence mechanism of employees’ job crafting on safety innovation performance using the self-determination theory and suggests that psychological empowerment is critical in determining how employees’ job crafting influences safety innovation performance. Furthermore, both employees’ mindfulness traits and job complexity positively moderate the above mediation.
A comprehensive framework for examining the influence of tower crane safe operations on sustainable practices in modular integrated construction
Authors: Ali Ali Hassan , Zayed Tarek , Abdulai Sulemana Fatoama , Wang Roy Dong 
Published: October 2024

PurposeThis study aims to explore the tower crane safety factors (TCSFs) that influence tower crane safe operations (TCSOs) in modular integrated construction (MiC). It evaluates how the adoption of these factors contributes to achieving TCSOs and promoting sustainable practices (SPs) within MiC.Design/methodology/approachTo achieve this aim, the study employed a systematic search to ensure a comprehensive collection of variables. Additionally, it conducted a questionnaire survey involving professionals and utilized a brainstorming technique to categorize the different variables. Finally, partial least squares structural equation modeling (PLS-SEM) was employed to test the relationship between TCSOs and SPs.FindingsThe results of measurement models indicated strong convergent and discriminant validity, with each observed variable correlating well with its latent variable. Moreover, a significant positive correlation between TCSOs and SPs was evidenced by a path coefficient (β = 0.755) and ap-value of <0.05. Lastly, the structural model revealed that the independent variables strongly influence the dependent variable (i.e. SPs) by 57%, underscoring safety's pivotal role in advancing sustainability within MiC projects. These findings provide empirical evidence that improving tower crane safety can directly enhance sustainable practices, offering a dual benefit of increased safety and sustainability for the construction sector.Originality/valueThis study makes a unique and previously undiscovered contribution to the field by identifying the TCSFs in MiC and employing a novel approach by utilizing PLS-SEM to create a unique mathematical model. It offers valuable insights into the relationship between TCSFs, TCSOs and SPs, thus contributing to methodological advancements within Safety Science and providing a foundation for future research and practical implementation in the construction industry.
Discrimination in the hiring process – state of the art and implications for policymakers
Authors: Calluso Cinzia , Devetag Maria Giovanna 
Published: October 2024

PurposeDespite the increasing heterogeneity of the organizational workforce – as a consequence of major worldwide socioeconomic trends – a considerable number of studies shows how traditionally underrepresented groups still face significant barriers in entering the labor market. Literature has highlighted several grounds for discrimination: ethnicity, age, gender, religion, social status, sexual orientation, etc., and while some of these are extensively investigated (e.g. ethnicity), other fields are still gaining evidence (e.g. social status).Design/methodology/approachIn the current paper, we aim at providing a review of current experimental studies aimed at detecting discrimination in hiring and the possible interventions to reduce bias. Then, we offer a point of reflection for policymaking, analyzing whether such issue should be addressed at the level of the individual (i-frame) or rather at a more systemic level (s-frame).FindingsThe paper provides substantial evidence that discrimination in hiring still exists, despite the never greater pressure for firms’ social sustainability. Further, existing interventions appear to have an overall limited impact in reducing bias. Hence, we suggest that the issue of discrimination in hiring should be tackled at a systemic level, by means of s-frame interventions.Originality/valueThe paper offers a comprehensive understanding of the phenomenon by systematizing the existing body of knowledge deriving from empirical research and offering a broad perspective onto policy implications.