bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial Burden in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study
Authors: Nipp Ryan D. , Kirchhoff Anne C. , Fair Douglas , Rabin Julia , Hyland Kelly A. , Kuhlthau Karen , Perez Giselle K. , Robison Leslie L. , Armstrong Gregory T. , Nathan Paul C. , Oeffinger Kevin C. , Leisenring Wendy M. , Park Elyse R. 
Published: August 2017

Purpose Survivors of childhood cancer may experience financial burden as a result of health care costs, particularly because these patients often require long-term medical care. We sought to evaluate the prevalence of financial burden and identify associations between a higher percentage of income spent on out-of-pocket medical costs (≥ 10% of annual income) and issues related to financial burden (jeopardizing care or changing lifestyle) among survivors of childhood cancer and a sibling comparison group. Methods Between May 2011 and April 2012, we surveyed an age-stratified, random sample of survivors of childhood cancer and a sibling comparison group who were enrolled in the Childhood Cancer Survivor Study. Participants reported their household income, out-of-pocket medical costs, and issues related to financial burden (questions were adapted from national surveys on financial burden). Logistic regression identified associations between participant characteristics, a higher percentage of income spent on out-of-pocket medical costs, and financial burden, adjusting for potential confounders. Results Among 580 survivors of childhood cancer and 173 siblings, survivors of childhood cancer were more likely to have out-of-pocket medical costs ≥ 10% of annual income (10.0% v 2.9%; P < .001). Characteristics of the survivors of childhood cancer that were associated with a higher percentage of income spent on out-of-pocket costs included hospitalization in the past year (odds ratio [OR], 2.3; 95% CI, 1.1 to 4.9) and household income < $50,000 (OR, 5.5; 95% CI, 2.4 to 12.8). Among survivors of childhood cancer, a higher percentage of income spent on out-of-pocket medical costs was significantly associated with problems paying medical bills (OR, 8.9; 95% CI, 4.4 to 18.0); deferring care for a medical problem (OR, 3.0; 95% CI, 1.6 to 5.9); skipping a test, treatment, or follow-up (OR, 2.1; 95% CI, 1.1 to 4.0); and thoughts of filing for bankruptcy (OR, 6.6; 95% CI, 3.0 to 14.3). Conclusion Survivors of childhood cancer are more likely to report spending a higher percentage of their income on out-of-pocket medical costs, which may influence their health-seeking behavior and potentially affect health outcomes. Our findings highlight the need to address financial burden in this population with long-term health care needs.
CONKO-005: Adjuvant Chemotherapy With Gemcitabine Plus Erlotinib Versus Gemcitabine Alone in Patients After R0 Resection of Pancreatic Cancer: A Multicenter Randomized Phase III Trial
Authors: Sinn Marianne , Bahra Marcus , Liersch Torsten , Gellert Klaus , Messmann Helmut , Bechstein Wolf , Waldschmidt Dirk , Jacobasch Lutz , Wilhelm Martin , Rau Bettina M. , Grützmann Robert , Weinmann Arndt , Maschmeyer Georg , Pelzer Uwe , Stieler Jens M. , Striefler Jana K. , Ghadimi Michael , Bischoff Sven , Dörken Bernd , Oettle Helmut , Riess Hanno 
Published: August 2017

Purpose Gemcitabine is standard of care in the adjuvant treatment of resectable pancreatic ductal adenocarcinoma (PDAC). The epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in combination with gemcitabine has shown efficacy in the treatment of advanced PDAC and was considered to improve survival in patients with primarily resectable PDAC after R0 resection. Patients and Methods In an open-label, multicenter trial, patients were randomly assigned to one of two study arms: gemcitabine 1,000 mg/m2 days 1, 8, 15, every 4 weeks plus erlotinib 100 mg once per day (GemErlo) or gemcitabine (Gem) alone for six cycles. The primary end point of the study was to improve disease-free survival (DFS) from 14 to 18 months by adding erlotinib to gemcitabine. Results In all, 436 patients were randomly assigned at 57 study centers between April 2008 and July 2013. A total of 361 instances (83%) of disease recurrence were observed after a median follow-up of 54 months. Median treatment duration was 22 weeks in both arms. There was no difference in median DFS (GemErlo 11.4 months; Gem 11.4 months) or median overall survival (GemErlo 24.5 months; Gem 26.5 months). There was a trend toward long-term survival in favor of GemErlo (estimated survival after 1, 2, and 5 years for GemErlo was 77%, 53%, and 25% v 79%, 54%, and 20% for Gem, respectively). The occurrence or the grade of rash was not associated with a better survival in the GemErlo arm. Conclusion To the best of our knowledge, CONKO-005 is the first study to investigate the combination of chemotherapy and a targeted therapy in the adjuvant treatment of PDAC. GemErlo for 24 weeks did not improve DFS or overall survival over Gem.
Cabozantinib As Salvage Therapy for Patients With Tyrosine Kinase Inhibitor–Refractory Differentiated Thyroid Cancer: Results of a Multicenter Phase II International Thyroid Oncology Group Trial
Authors: Cabanillas Maria E. , de Souza Jonas A. , Geyer Susan , Wirth Lori J. , Menefee Michael E. , Liu Stephen V. , Shah Komal , Wright John , Shah Manisha H. 
Published: August 2017

Purpose Sorafenib and lenvatinib are oral multikinase inhibitors targeting vascular endothelial growth factor receptor (VEGFR) and approved for radioiodine (RAI)-refractory differentiated thyroid cancer (DTC). However, there are no approved second- or third-line therapies. MET is implicated in resistance to VEGFR inhibitors. Cabozantinib is an oral multikinase inhibitor targeting MET in addition to VEGFR and is approved for medullary thyroid cancer. In a phase I study of cabozantinib, five of eight patients with DTC previously treated with a VEGFR-targeted therapy had an objective response to cabozantinib. Patients and Methods Patients with RAI-refractory disease with Response Evaluation Criteria in Solid Tumor (RECIST) measurable disease and evidence of progression on prior VEGFR-targeted therapy were enrolled in this single-arm phase II study. The cabozantinib starting dose was 60 mg/day orally but could be escalated to 80 mg if the patient did not experience a response. Patients underwent tumor assessment according to RECIST v1.1 every 8 weeks. In this study, if at least five of 25 response-evaluable patients had an objective response, cabozantinib would be considered a promising agent in this patient population. Results Twenty-five patients were enrolled. The median age was 64 years, and 64% of patients were men. Twenty-one patients had received only one prior VEGFR-targeted therapy (sorafenib, pazopanib, or cediranib), and four patients had received two such therapies. The most common treatment-related adverse events were fatigue, weight loss, diarrhea, palmar-plantar erythrodysesthesia, and hypertension. One drug-related death was noted. Of the 25 patients, 10 (40%) had a partial response, 13 (52%) had stable disease, and two (8%) had nonevaluable disease. The median progression-free survival and overall survival were 12.7 months and 34.7 months, respectively. Conclusion Cabozantinib demonstrated clinically significant, durable objective response activity in patients with RAI-refractory DTC who experienced disease progression while taking prior VEGFR-targeted therapy.
Long-Term Survival Outcomes of Cancer-Directed Surgery for Malignant Pleural Mesothelioma: Propensity Score Matching Analysis
Authors: Nelson David B. , Rice David C. , Niu Jiangong , Atay Scott , Vaporciyan Ara A. , Antonoff Mara , Hofstetter Wayne L. , Walsh Garrett L. , Swisher Stephen G. , Roth Jack A. , Tsao Anne , Gomez Daniel , Giordano Sharon H. , Mehran Reza , Sepesi Boris 
Published: August 2017

Purpose Small observational studies have shown a survival advantage to undergoing cancer-directed surgery for malignant pleural mesothelioma (MPM); however, it is unclear if these results are generalizable. Our purpose was to evaluate survival after treatment of MPM with cancer-directed surgery and to explore the effect surgery interaction with chemotherapy or radiation therapy on survival by using the National Cancer Database. Patients and Methods Patients with microscopically proven MPM were identified within the National Cancer Database (2004 to 2014). Propensity score matching was performed 1:2 and among this cohort, a Cox proportional hazards regression model was used to identify predictors of survival. Median survival was calculated by using the Kaplan-Meier method. Results Of 20,561 patients with MPM, 6,645 were identified in the matched cohort, among whom 2,166 underwent no therapy, 2,015 underwent chemotherapy alone, 850 underwent cancer-directed surgery alone, 988 underwent surgery with chemotherapy, and 274 underwent trimodality therapy. The remaining 352 patients underwent another combination of surgery, radiation, or chemotherapy. Thirty-day and 90-day mortality rates were 6.3% and 15.5%. Cancer-directed surgery, chemotherapy, and radiation therapy were independently associated with improved survival (hazard ratio, 0.77, 0.74, and 0.88, respectively). Stratified analysis revealed that surgery-based multimodality therapy demonstrated an improved survival compared with surgery alone, with no significant difference between surgery-based multimodality therapies; however, the largest estimated effect was when cancer-directed surgery, chemotherapy, and radiation therapy were combined (hazard ratio, 0.52). For patients with the epithelial subtype who underwent trimodality therapy, median survival was extended from 14.5 months to 23.4 months. Conclusion MPM is an aggressive and rapidly fatal disease. Surgery-based multimodality therapy was associated with improved survival and may offer therapeutic benefit among carefully selected patients.
A Patient (46XX) With Congenital Adrenal Hyperplasia and Prostate Cancer: A Case Report
Authors: Wesselius Ruben , Schotman Mirjam , Schotman Martje , Pereira Alberto M 
Published: August 2017

Abstract
Congenital adrenal hyperplasia (CAH) can affect sex characteristics. The most common cause of CAH is 21-hydroxylase deficiency, and the cornerstone of treatment is glucocorticoid replacement in adrenocorticotropic hormone-suppressive dosages. A 64-year-old patient (46XX) with CAH resulting from 21-hydroxylase deficiency had been treated with dexamethasone and testosterone since diagnosis at age 12 and was phenotypically male. At age 62, he was diagnosed with prostate carcinoma. The patient received curative treatment with external beam radiotherapy. Genotypically female patients with CAH can develop prostate carcinoma when receiving long-term testosterone replacement therapy.
Case Report: Synchronous primary malignancy including the breast and endometrium
Authors: Banimostafavi Elham Sadat , Tayebi Sepideh , Tayebi Maryam 
Published: August 2017

Breast and endometrial cancer are the most common types of female cancers, but the incidence of both of these malignancies in a single patient is a rare event. Multiple primary malignancy has been increasingly reported over the past decade, and double primary cancer is considered as the most common type. In this study, we present a 53-year-old woman with synchronous primary malignancy of breast and endometrium. This patient had a history of breast and endometrial cancer in her family. Mammography and chest CT of the patient revealed a mass in the right breast and left supraclavicular region. However, the patient did not want to initiate treatment. Subsequently, the patient returned with a chief complaint of persistent abnormal vaginal bleeding. Abdominopelvic CT scan of the patient revealed a huge soft tissue mass in the pelvic cavity. She underwent hysterectomy, and pathology revealed endometrioid carcinoma, which had invaded the full thickness of uterine wall. Since this type of malignancy is rare and several risk factors are associated with it, it is worth being considered by clinicians when making decisions about screening or strategy for prevention.
Tree shape and form in ancient coppice woodlands
Authors: Maděra Petr , Slach Tomáš , Úradníček Luboš , Lacina Jan , Černušáková Linda , Friedl Michal , Řepka Radomír , Buček Antonín 
Published: August 2017

Abstract
Ancient coppice woodlands are coppice-originated forest stands with a long-term continual development, and with the preserved typical natural and historic elements of old sprout forests. Prominent natural elements in the ancient coppice woodlands are namely old coppice stools. There is, in scientific literature, lack of information about features of ancient coppice stools. Therefore, our contribution aims to describe shape and form of ancient coppice stools, including the most important microhabitat of coppice woodlands – dendrothelms. Based on field survey of 20 localities of important coppice woodlands we recorded 135 ancient coppice stools of 13 tree species and a total of 80 dendrothelms in 9 tree species. Basic features of ancient coppice stools and dendrothlems were measured and evaluated.
Determinanten der Erkennung und Bewertung von Objekttypen. Eine linguistisch-differenziell-psychologische Studie zum Genitiv
Authors: Wich-Reif Claudia , Leue Anja , Beauducel André 
Published: August 2017

Abstract
It is self-evident that language changes across time; how this process of language change takes place has been investigated for specific domains, such as the genitive case. Language change may induce a heterogeneity of verbal competences. However, in differential psychology theoretical models on verbal intelligence imply that verbal competence is a rather homogeneous. Accordingly, the question of homogeneity and heterogeneity of verbal competences is a rather open one. Therefore, this study investigates the competence of differentiating sentences with genitive verbs from other object types and of evaluating the familiarity with these object types. It was examined whether homogeneous or heterogeneous linguistic competences are relevant for the evaluation of the grammatical correctness of sentences. The methodological basis for the linguistic and differential psychological study was a questionnaire of 22 groups of sentences with verbs requiring the genitive as an object case and/or verbs requiring another object case. Participants (N = 177 students) were asked to evaluate the grammatical correctness of the sentences (correct vs. incorrect) and the familiarity of content of the sentences on a six point Likert scale. Based on a statistical method termed principal component analysis, the relevance of homogenous vs. heterogeneous linguistic competences was investigated. This analysis led to six principal components which can be differentiated with regard to their relevance for linguistic competences. In addition, it could be demonstrated that the mother tongue (German vs. non-German) and the course of study (German studies or Psychology) influenced the evaluation of correctness. The findings indicate that relations between specific linguistic competences and verbal intelligence should be analyzed with regard to language and socialization processes.
A Brief Review of Handgrip Strength and Sport Performance
Authors: Cronin John , Lawton Trent , Harris Nigel , Kilding Andrew , McMaster Daniel T. 
Published: August 2017

AbstractCronin, J, Lawton, T, Harris, N, Kilding, A, and McMaster, DT. A brief review of handgrip strength and sport performance.J Strength Cond Res31(11): 3187–3217, 2017—Tests of handgrip strength (HGS) and handgrip force (HGF) are commonly used across a number of sporting populations. Measures of HGS and HGF have also been used by practitioners and researchers to evaluate links with sports performance. This article first evaluates the validity and reliability of various handgrip dynamometers (HGD) and HGF sensors, providing recommendations for procedures to ensure that precise and reliable data are collected as part of an athlete's testing battery. Second, the differences in HGS between elite and subelite athletes and the relationships between HGS, HGF, and sports performance are discussed.
Technical and Tactical Aspects in Italian Youth Rugby Union in Relation to Different Academies, Regional Tournaments, and Outcomes
Authors: Ungureanu Alexandru N. , Condello Giancarlo , Pistore Simonluca , Conte Daniele , Lupo Corrado 
Published: August 2017

Abstract
Ungureanu, AN, Condello, G, Pistore, S, Conte, D, and Lupo, C. Technical and tactical aspects in Italian youth rugby union in relation to different academies, regional tournaments, and outcomes. J Strength Cond Res 33(6): 1557–1569, 2019—This study aimed to analyze the technical and tactical aspects of the Italian under-18 Academy Rugby Union in relation to different academies, regional tournaments, and game outcomes. A notational analysis (44 indicators) was performed on 16 games (2014–15 season) to evaluate strong differences (p ≤ 0.05; moderate-large effect sizes [ESs]) according to variables. Among academies, strong differences were showed for defensive breakdown, in which the defending support is much (range = 77–87%), equal (range = 11–32%), and less (range = 2–12%) numerous than the attacking support, total tackles (range = 64–122), and passes (range = 72–151), pass to possession ratio (range = 6–10), possession lost due to an error (range = 28–59%), and ball in play in own (range = 8–25%) and opponent (range = 7–31%) 22-m area indicators. For tournaments, effects emerged for offensive breakdown when the ball is used quickly using maximum 2 attacking supports (range = 20–30%) and is not used quickly (range = 28–41%), total penalty kicks (range = 11–16), and sequences period 0–10 (range = 26–35%) and 10–40 seconds (range = 47–55%). Conversely, winning and losing academies reported differences with small ESs. These results highlight that the technical and tactical aspects of the Italian under-18 Academy Rugby Union are quite homogeneous, suggesting that FIR coaching staffs are more oriented to players' skills than successful games. However, tactical and strength and conditioning coaches can benefit from the findings of this study, focusing training on cognitive, strength, and repeated sprint abilities with and without change of direction for improving the occurrence of “set pieces won/regained” and “ball in play in opponent 22 m area,” which appear as the key of the game in this rugby competition level.
Water Absorption in Cementitious Materials at Different Temperatures
Authors: Wei Jianqiang , Tao Bernard , Weiss W. Jason 
Published: August 2017

Abstract
This paper presents results from an experimental investigation that assessed water absorption in cementitious materials at different temperatures. This work aims to determine whether the absorption behavior may be explained by considering only temperature related variations in the fluid properties (surface tension, viscosity, and density). The calculated water absorption curves at 5°C and 40°C (based on adjusting the absorption that was measured at 23°C using the temperature dependent fluid properties) exhibit agreement with the experimental data for the secondary sorption. This indicates that the change of fluid properties as a function of temperature is the primary reason for the difference in behavior. As a result, it appears possible to predict the rate of secondary absorption of cementitious materials at various temperatures with a simple correction. The initial sorptivity also showed a temperature dependency; however, the dependency of the mortars with water-to-cement ratios of 0.30 and 0.50 was 50 % and 64 % greater than that obtained using only the temperature dependent fluid properties. This indicates that, in addition to variations in the properties of the fluid, the interaction between the fluid and cementitious materials may also have a temperature dependence that influences the initial sorptivity. The transition between initial and secondary sorption (i.e., nick point) occurs at an earlier time with increasing temperature due to the increased rate of fluid absorption.
Sustainable Manufacturing Performance Evaluation at the Enterprise Level: Index- and Value-Based Methods
Authors: Huang A. , Badurdeen F. 
Published: August 2017

Abstract
Sustainability is a key principle that has been intensely discussed over the past two decades. In this context, sustainable manufacturing, which involves the use of sustainable processes and systems to produce more sustainable products, is becoming increasingly important for corporate success. Companies that compete globally are increasingly required to commit to and report on the overall sustainability performance of operational initiatives. While a variety of performance evaluation methods have been presented in literature, for sustainable manufacturing performance evaluation at the enterprise level, none comprehensively cover the three pillars of sustainability, embrace the total life-cycle perspective, or consider the 6Rs of reduce, reuse, recover, redesign, and remanufacture simultaneously. In this paper, two alternate index-based and value-based methods were proposed to evaluate sustainable manufacturing performance at the enterprise level to comprehensively consider all the previously mentioned aspects. A sustainable manufacturing performance evaluation framework was used to identify enterprise sustainability metrics which are then converted to an index with a five-level hierarchical process. The same metrics were then used to propose a value-based measure for enterprise level sustainable manufacturing performance evaluation. Application of these two methods were illustrated for a representative enterprise producing consumer electronics to compare and analyze performance over a four year period. The two methods provide comparable results, indicating either can be used to evaluate sustainable manufacturing performance at the enterprise level in manufacturing organizations. The assessment methods also provide insights for future studies that can further explore sustainability metrics and evaluation methods for other levels across the supply chain.