bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trajectories of sexual well-being and links with grief after a recent pregnancy loss: a dyadic longitudinal study
Authors: Allsop David B , Péloquin Katherine , Cockwell Heather , Rosen Natalie O 
Published: September 2024

Abstract

Background
Pregnancy loss affects 1 in 4 women and is linked with poorer overall health and relationship outcomes. Despite sexual well-being’s importance to health, how sexual well-being changes across time after a pregnancy loss and what might predict such changes, like perinatal grief, have never been examined, leaving practitioners and couples without knowledge of what to expect.

Aim
We aimed to examine (1) how sexual satisfaction, sexual desire, sexual distress, and perinatal grief change from 10 to 25 weeks postloss for both couple members; and (2) if perinatal grief levels at 10 weeks postloss predict sexual well-being trajectories.

Methods
Women and gender-diverse individuals who were pregnant when a pregnancy loss occurred (within the last 4 months) and men, women, and gender-diverse partners who were not pregnant (N = 132 couples) independently completed 4 monthly assessments of sexual well-being and perinatal grief.

Outcomes
Outcomes included sexual satisfaction (Global Measure of Sexual Satisfaction), sexual desire (Sexual Desire Inventory), sexual distress (Sexual Distress Scale–Short Form), perinatal grief (Perinatal Grief Scale).

Results
Dyadic growth curve modeling indicated that, from 10 to 25 weeks postloss, both couple members’ sexual satisfaction increased, and their sexual desire remained stable; sexual distress decreased for partners but remained stable for individuals who were pregnant; and both couple members’ perinatal grief decreased. Perinatal grief levels at 10 weeks postloss did not predict sexual well-being trajectories over time.

Clinical Implications
Given sexual well-being’s dynamic nature, clinicians should regularly discuss sexuality with both couple members after pregnancy loss. During such discussions, clinicians could reassure couples about their sexual relationship’s recovery by sharing that, on average, sexual satisfaction, sexual desire, and sexual distress tend to improve or stay the same (rather than worsen) from 10 to 25 weeks postloss. They can also share that perinatal grief tends to decrease during this time and is unrelated to trajectories of sexual satisfaction, sexual desire, and sexual distress.

Strengths and limitations
This is the first study, to our knowledge, to examine how sexual well-being changes across time after a pregnancy loss and perinatal grief’s role in such changes. The results may not generalize broadly, as most couples were in mixed-gender/sex relationships, identified as White, and were relatively affluent.

Conclusion
From 10 to 25 weeks postloss, both couple members tend to experience improvements in their overall sexual well-being and declines in their perinatal grief. Early perinatal grief levels and subsequent sexual well-being trajectories are seemingly unrelated.
Constraining the physical properties of large-scale jets from black hole X-ray binaries and their impact on the local environment with blast-wave dynamical models
Authors: Carotenuto F , Fender R , Tetarenko A J , Corbel S , Zdziarski A A , Shaik G , Cooper A J , Palma I Di 
Published: September 2024

ABSTRACT
Relativistic discrete ejecta launched by black hole X-ray binaries (BH XRBs) can be observed to propagate up to parsec-scales from the central object. Observing the final deceleration phase of these jets is crucial to estimate their physical parameters and to reconstruct their full trajectory, with implications for the jet powering mechanism, composition, and formation. In this paper, we present the results of the modelling of the motion of the ejecta from three BH XRBs: MAXI J1820$+$070, MAXI J1535–571, and XTE J1752–223, for which high-resolution radio and X-ray observations of jets propagating up to $\sim$15 arcsec ($\sim$0.6 pc at 3 kpc) from the core have been published in the recent years. For each jet, we modelled its entire motion with a dynamical blast-wave model, inferring robust values for the jet Lorentz factor, inclination angle and ejection time. Under several assumptions associated to the ejection duration, the jet opening angle and the available accretion power, we are able to derive stringent constraints on the maximum jet kinetic energy for each source (between $10^{43}$ and $10^{44}$ erg, including also H1743–322), as well as placing interesting upper limits on the density of the ISM through which the jets are propagating (from $n_{\rm ISM} \lesssim 0.4$ cm$^{-3}$ down to $n_{\rm ISM} \lesssim 10^{-4}$ cm$^{-3}$). Overall, our results highlight the potential of applying models derived from gamma-ray bursts to the physics of jets from BH XRBs and support the emerging picture of these sources as preferentially embedded in low-density environments.
Exploring mass measurements of supermassive black holes in AGN using GAMA photometry and spectroscopy
Authors: Casura Sarah , Ilić Dragana , Targaczewski Jonathan , Rakić Nemanja , Liske Jochen 
Published: September 2024

ABSTRACT
In the era of massive photometric surveys, we explore several approaches to estimate the masses of supermassive black holes (SMBHs) in active galactic nuclei (AGNs) from optical ground-based imaging, in each case comparing to the independent SMBH mass measurement obtained from spectroscopic data. We select a case-study sample of 28 type 1 AGN hosted by nearby galaxies from the Galaxy And Mass Assembly (GAMA) survey. We perform multicomponent spectral decomposition, extract the AGN component, and calculate the SMBH mass from the broad H$\alpha$ emission line width and luminosity. The photometric g and i band data is decomposed into AGN+spheroid(+disc)(+bar) components with careful surface brightness fitting. From these, the SMBH mass is estimated using its relation with the spheroid Sérsic index or effective radius (both used for the first time on ground-based optical imaging of AGN); and the more widely used scaling relations based on bulge or galaxy stellar mass. We find no correlation between the H$\alpha$-derived SMBH masses and those based on the spheroid Sérsic index or effective radius, despite these being the most direct methods involving only one scaling relation. The bulge or galaxy stellar mass based methods both yield significant correlations, although with considerable scatter and, in the latter case, a systematic offset. We provide possible explanations for this and discuss the requirements, advantages, and drawbacks of each method. These considerations will be useful to optimize strategies for upcoming high quality ground-based and space-borne sky surveys to estimate SMBH masses in large numbers of AGN.
A GMRT 610 MHz radio survey of the North Ecliptic Pole (NEP, ADF-N) / Euclid Deep Field North
Authors: White Glenn J , Barrufet L , Serjeant S , Pearson C P , Sedgwick C , Pal S , Shimwell T W , Sirothia S K , Chiu P , Oi N , Takagi T , Shim H , Matsuhara H , Patra D , Malkan M , Kim H K , Nakagawa T , Malek K , Burgarella D , Ishigaki T 
Published: September 2024

ABSTRACT
This paper presents a 610 MHz radio survey covering 1.94 deg$^2$ around the North Ecliptic Pole (NEP), which includes parts of the ${\it AKARI}$ (ADF-N) and Euclid, Deep Fields North. The median 5$\sigma$ sensitivity is 28 $\mu$Jy beam$^{-1}$, reaching as low as 19 $\mu$Jy beam$^{-1}$, with a synthesized beam of 3.6 arcsec $\times$ 4.1  arcsec. The catalogue contains 1675 radio components, with 339 grouped into multicomponent sources and 284 ‘isolated’ components likely part of double radio sources. Imaging, cataloguing, and source identification are presented, along with preliminary scientific results. From a non-statistical sub-set of 169 objects with multiwavelength AKARI and other detections, luminous infrared galaxies (LIRGs) represent 66 ${{\ \rm per\ cent}}$ of the sample, ultra-luminous infrared galaxies (ULIRGs) 4 ${{\ \rm per\ cent}}$, and sources with L$_{IR}$ &lt; 10$^{11}$ $\mathrm{ L}_{\odot }\,$ 30${{\ \rm per\ cent}}$. In total, 56 ${{\ \rm per\ cent}}$ of sources show some AGN presence, though only seven are AGN-dominated. ULIRGs require three times higher AGN contribution to produce high-quality SED fits compared to lower luminosity galaxies, and AGN presence increases with AGN fraction. The PAH mass fraction is not significant, although ULIRGs have about half the PAH strength of lower IR-luminosity galaxies. Higher luminosity galaxies show gas and stellar masses an order of magnitude larger, suggesting higher star formation rates. For LIRGs, AGN presence increases with redshift, indicating that part of the total luminosity could be contributed by AGN activity rather than star formation. Simple cross-matching revealed 13 ROSAT QSOs, 45 X-ray sources, and 61 sub-mm galaxies coincident with GMRT radio sources.
Stable potassium isotope ratios in human blood serum towards biomarker development in Alzheimer's disease
Authors: Mahan Brandon , Hu Yan , Lahoud Esther , Nestmeyer Mark , McCoy-West Alex , Manestar Grace , Fowler Christopher , Bush Ashley I , Moynier Frédéric 
Published: September 2024

Abstract
The Alzheimer's disease (AD)-affected brain purges K with concurrently increasing serum K, suggesting brain–blood K transferal. Here, natural stable K isotope ratios—δ41K—of human serum samples were characterized in an AD biomarker pilot study (plus two paired Li-heparin and potassium ethylenediaminetetraacetic acid [K-EDTA] plasma samples). AD serum was found to have a significantly lower mean δ41K relative to controls. To mechanistically explore this change, novel ab initio calculations (density functional theory) of relative K isotope compositions between hydrated K+ and organically bound K were performed, identifying hydrated K+ as isotopically light (lower δ41K) compared to organically bound K. Taken together with literature, serum δ41K and density functional theory results are consistent with efflux of hydrated K+ from the brain to the bloodstream, manifesting a measurable decrease in serum δ41K. These data introduce serum δ41K for further investigation as a minimally invasive AD biomarker, with cost, scalability, and stability advantages over current techniques.
Second generation lethality in RNAseH2a knockout zebrafish
Authors: Thomas Ruth C , Zaksauskaite Ringaile , Al-Kandari Norah Y , Hyde Anne Cathrine , Abugable Arwa A , El-Khamisy Sherif F , van Eeden Freek J 
Published: September 2024

Abstract
Removal of ribonucleotides from DNA by RNaseH2 is essential for genome stability, and its impacted function causes the neurodegenerative disease, Aicardi Goutières Syndrome. We have created a zebrafish rnaseh2a mutant to model this process. Surprisingly, RNaseH2a knockouts show little phenotypic abnormality at adulthood in the first generation, unlike mouse knockout models, which are early embryonic lethal. However, the second generation offspring show reduced development, increased ribonucleotide incorporation and upregulation of key inflammatory markers, resulting in both maternal and paternal embryonic lethality. Thus, neither fathers or mothers can generate viable offspring even when crossed to wild-type partners. Despite their survival, rnaseh2a−/− adults show an accumulation of ribonucleotides in both the brain and testes that is not present in early development. Our data suggest that homozygotes possess RNaseH2 independent compensatory mechanisms that are inactive or overwhelmed by the inherited ribonucleotides in their offspring, or that zebrafish have a yet unknown tolerance mechanism. Additionally, we identify ribodysgenesis, the rapid removal of rNMPs and subsequently lethal fragmentation of DNA as responsible for maternal and paternal embryonic lethality.
Unlocking precision in aptamer engineering: a case study of the thrombin binding aptamer illustrates why modification size, quantity, and position matter
Authors: Murray Makay T , Wetmore Stacey D 
Published: September 2024

Abstract
The thrombin binding aptamer (TBA) is a prototypical platform used to understand the impact of chemically-modified nucleotides on aptamer stability and target affinity. To provide structural insight into the experimentally-observed effects of modification size, location, and number on aptamer performance, long time-scale molecular dynamics (MD) simulations were performed on multiple binding orientations of TBA–thrombin complexes that contain a large, flexible tryptophan thymine derivative (T-W) or a truncated analogue (T-K). Depending on modification position, T-W alters aptamer–target binding orientations, fine-tunes aptamer–target interactions, strengthens networks of nucleic acid–protein contacts, and/or induces target conformational changes to enhance binding. The proximity and 5′-to-3′ directionality of nucleic acid structural motifs also play integral roles in the behavior of the modifications. Modification size can differentially influence target binding by promoting more than one aptamer–target binding pose. Multiple modifications can synergistically strengthen aptamer–target binding by generating novel nucleic acid–protein structural motifs that are unobtainable for single modifications. By studying a diverse set of modified aptamers, our work uncovers design principles that must be considered in the future development of aptamers containing chemically-modified nucleotides for applications in medicine and biotechnology, highlighting the value of computational studies in nucleic acids research.
Association of shared decision-making with financial toxicity and coping actions in adult patients with cancer: a nationwide study in China
Authors: Liu Meicen , Huang Dengmin , Ma Jing , Wei Wenqiang , Liu Yuanli 
Published: September 2024

Abstract

Objective
Evidence on the impact of shared decision-making (SDM) on the financial toxicity (FT) of patients with cancer in real clinical settings is lacking. Using a nationwide patient survey in China, we aimed to identify the prevalence of SDM, FT as well as its consequent coping actions, and investigate their associations in adult patients with cancer.

Methods
A cross-sectional survey was administered to patients with cancer near discharge at 33 tertiary public cancer hospitals across China between January and March 2021. The FT was measured using the COST (comprehensive score for financial toxicity) tool and was categorized into 3 groups: no (COST 26-44), mild (COST 14-25), and moderate or severe (COST 0-13) FT. SDM was measured using 2 items from patient’s perspective. The surveyed questionnaire also included patient’s coping actions, demographics, and clinical information. Multinomial logistic regression was used to investigate the association between SDM and FT, and for sensitivity analysis, linear regression was also used taking the COST score as a dependent variable. Pearson’s chi-square tests were used for association analyses of coping actions with FT and SDM.

Results
A total of 5008 adult patients with cancer were included, of which 26.18%, 54.13%, and 19.69% patients were categorized as no FT, mild FT, and moderate or severe FT with the average COST score of 21.0 for all patients. Besides, 3943 (78.73%) patients reported a better SDM. Better SDM had significantly lower odds of developing high FT than worse SDM (adjusted ORmild vs no 0.50, 95% CI 0.39-0.56; adjusted ORmoderate or severe vs no 0.63, 95% CI 0.50-0.80). In sensitivity analysis, better SDM was significantly associated with higher COST scores (β: 1.34, 95% CI 0.85-1.83), which indicated lower FT. Patients with higher FT were more likely to take adverse coping actions including treatment nonadherence, limiting basic health service expense, reducing leisure activity expense, and loan.

Conclusions
Adult patients with cancer reporting worse SDM tended to experience higher FT and those with higher FT tended to take adverse coping actions. Understanding the impact of SDM on FT is crucial to inform early interventions designed to mitigate FT and consequent coping actions in cancer care practice.
C2-domain abscisic acid-related proteins regulate the dynamics of a plasma membrane H+-ATPase in response to alkali stress
Authors: Guo Ai-Yu , Wu Wen-Qiang , Liu Wen-Cheng , Zheng Yuan , Bai Di , Li Yan , Xie Jie , Guo Siyi , Song Chun-Peng 
Published: September 2024

Abstract
Arabidopsis (Arabidopsis thaliana) H+-ATPase1 (AHA1), a plasma membrane (PM)-localized H+-ATPase, plays a key role in plant alkali stress tolerance by pumping protons from the cytoplasm to the apoplast. However, its molecular dynamics are poorly understood. We report that many C2-domain ABA-related (CAR) protein family members interact with AHA1 in Arabidopsis. Single or double mutants of CAR1, CAR6, and CAR10 had no obvious phenotype of alkali stress tolerance, while their triple mutants showed significantly higher tolerance to this stress. The disruption of AHA1 largely compromised the increased alkali stress tolerance of the car1car6car10 mutant, revealing a key role of CARs in AHA1 regulation during the plant's response to a high alkali pH. Furthermore, variable-angle total internal reflection fluorescence microscopy was used to observe AHA1-mGFP5 in intact Arabidopsis seedlings, revealing the presence of heterogeneous diffusion coefficients and oligomerization states in the AHA1 spots. In the aha1 complementation lines, alkali stress curtailed the residence time of AHA1 at the PM and increased the diffusion coefficient and particle velocity of AHA1. In contrast, the absence of CAR proteins decreased the restriction of the dynamic behavior of AHA1. Our results suggest that CARs play a negative role in plant alkali stress tolerance by interacting with AHA1 and provide a perspective to investigate the regulatory mechanism of PM H+-ATPase activity at the single-particle level.
Role of lumbar puncture level on the onset of epidural labor analgesia: a randomized controlled trial
Authors: Zhou Rui , Cao Yuansheng , Chen Xuemeng , Peng Yanhua , Xiong Chao , Zhai Wenhu , Zhang Xianjie , Zhou Yukai , Xiong Lize 
Published: September 2024

Abstract

Objective
To compare the speed of achieving painless uterine contractions in parturients undergoing epidural analgesia at different lumbar puncture levels.

Methods
This study is a randomized controlled trial at a tertiary A hospital with a history of over 80 years in Sichuan Province, China. Parturients aged 22–40 years old scheduled for vaginal delivery under epidural analgesia were recruited. Eligible patients were randomly allocated into lumbar 2-3 (L2-3) or lumbar 3-4 (L3-4) groups. Epidural analgesia was performed through the interspaces according to grouping. The primary outcome was the percentage of painless uterine contractions 15 min after the initiation of analgesia. The secondary outcomes included the percentage of painless status at 5 and 10 min, sensory block plane, motor block evaluation, adverse events of parturients, epidural analgesic consumption, Apgar score, and the parturients' evaluation of analgesia.

Results
Between April 2023 and August 2023, a total of 150 women were finally recruited, and 136 of them were analyzed (68 in each group). In comparison with the L3-4 groups, there was a significantly larger proportion of painless uterine contractions at 5, 10, and 15 min after analgesia initiation in the L2-3 group (20.6% vs. 7.4%, 52.9% vs. 26.5%, and 80.9% vs. 64.7%, P = .026, .002, and .034, respectively). Similarly, the pain scores were lower in the L2-3 group at 5, 10, and 15 min than that in the L3-4 group (5(4,7) vs. 6(5,7), 3(2,5) vs. 4(3,6), and 2(1,3) vs. 3(2,5), P = .006, .004, and .020, respectively). Furthermore, puncturing through the L2-3 interspace contributed to a higher evaluation of parturients to the analgesia procedure (9(8,9) vs. 8(8,9), P &lt; .001). However, there was no significant difference in sensory block, motor block, or adverse events between the two groups.

Conclusion
Puncturing through the L2-3 interspace is associated with faster pain relief and a better experience for parturients. These findings present a superior option for anesthesiologists when conducting epidural labor analgesia.
Key messages What is already known on this topic? Epidural analgesia is an effective way to relieve labor pain. What this study adds? Puncturing via lumbar 2-3 interspace induces more rapid onset of epidural analgesia. How this study might affect research, practice or policy? Lumbar 2-3 interspace is a superior option in terms of the speed of pain relief and satisfaction of parturients when conducting epidural labor analgesia.
Three Cases of Complex Eigenvalue/Vector Distributions of Symmetric Order-Three Random Tensors
Authors: Majumder Swastik , Sasakura Naoki 
Published: September 2024

Abstract
Random tensor models have applications in a variety of fields, such as quantum gravity, quantum information theory, mathematics of modern technologies, etc., and studying their statistical properties, e.g. tensor eigenvalue/vector distributions, is interesting and useful. Recently some tensor eigenvalue/vector distributions have been computed by expressing them as partition functions of 0D quantum field theories. In this paper, using this method, we compute three cases of complex eigenvalue/vector distributions of symmetric order-three random tensors, where the three cases can be characterized by the Lie-group invariances, $O(N,\mathbb {R})$, $O(N,\mathbb {C})$, and $U(N,\mathbb {C})$, respectively. Exact closed-form expressions of the distributions are obtained by computing partition functions of four-fermi theories, where the last case is of the “signed” distribution, which counts the distribution with a sign factor coming from a Hessian matrix. As an application, we compute the injective norm of the complex symmetric order-three random tensor in the large-N limit by computing the edge of the last signed distribution, obtaining agreement with an earlier numerical result in the literature.
Assessment of foetal dose and occupational exposure for pregnant workers in nuclear medicine using the Taiwanese pregnancy phantom
Authors: Chang Hao-Ting , Chang Yu-Chen , Hsu Fang-Yuh , Hsu Ching-Han 
Published: September 2024

Abstract
For pregnant workers in nuclear medicine, radiation doses can pose a risk to their foetus. However, foetal radiation doses cannot be measured directly. In this study, a method of estimating foetal radiation doses was developed through simulations and measurements of phantoms of pregnant women in the three trimesters. The uterus and abdominal surface doses for monoenergetic photons (137Cs) and medical diagnostic X-rays were measured, and uterine dose conversion coefficients (UDCCs) were calculated. The accuracy of the UDCC estimates were validated for measurements from thermoluminescent dosemeter (TLD) chips and TLD badges on the abdomen or chest. The foetal effective dose could be estimated using TLD chips and TLD badges on the abdomen or chest, or through literature estimation method. The proposed method can be used to easily and accurately estimate foetal effective doses from chest-worn TLD badges, ensuring accurate estimation in the early stage of pregnancy when a worker may not yet be wearing an abdominal badge. A flowchart for applying the UDCC method to approximate a foetal dose is also provided to ensure that total doses remain below the maximum of 1 mSv recommended in the International Commission on Radiological Protection 103 guidelines.