bluuebunny/crossref_metadata_2025_split huggingface dataset:
Herpes zoster development in living kidney transplant recipients receiving low‐dose rituximab
Authors: Nishida Hayato , Fukuhara Hiroki , Takai Satoshi , Nawano Takaaki , Takehara Tomohiro , Narisawa Takafumi , Kanno Hidenori , Yagi Mayu , Yamagishi Atsushi , Naito Sei , Tsuchiya Norihiko 
Published: October 2024

ObjectivesWe evaluated whether a history of low‐dose rituximab treatment affected herpes zoster development after living kidney transplantation.MethodsWe enrolled 103 living kidney transplant recipients. Patients were divided into two groups according to their history of rituximab treatment; rituximab was administered to 50 living kidney transplant recipients. We assessed the difference in herpes zoster events between the two groups and determined the risk factors for herpes zoster using multivariate regression analysis.ResultsThe total dose of rituximab in each kidney transplant recipient who received rituximab therapy was 200–400 mg. The rate of herpes zoster events after transplantation in recipients who received rituximab therapy (4 of 50, 8%) was not higher than that in recipients who did not receive rituximab (9 of 53, 17%) (p = 0.238). Herpes zoster‐free survival did not significantly differ between the two groups (p = 0.409). In the multivariate regression analysis, the association between varicella zoster vaccination before transplantation and herpes zoster events after transplantation was confirmed, whereas rituximab therapy was not associated with herpes zoster events.ConclusionsLow‐dose rituximab therapy in kidney transplant recipients did not influence herpes zoster development after transplantation. Varicella zoster vaccination before transplantation may play an important role in preventing herpes zoster after transplantation.
Peer‐to‐Peer Human Milk Sharing Through Social Media Groups: The Experiences of Women Donors and Recipients in Hong Kong
Authors: Li Junyan , Ip Hoi Lam , Liao Qiuyan , Lee Jung Jae , Lok Kris Yuet Wan 
Published: October 2024

ABSTRACTAimTo explore the lived experience of donors and recipients involved in peer‐to‐peer human milk donation.DesignAn exploratory descriptive qualitative study.MethodSemi‐structured interviews were conducted between November 2022 and April 2023. A total of 50 women consisting of 34 donors and 16 recipients were recruited using purposive sampling from specific social media groups in Hong Kong that focus on breast milk donation and sharing. Data were analysed based on thematic analysis.ResultsFive key themes were identified in this study: Motivation; Milk sharing as a social act; Not a Norm; Recommendation to formal milk banks; and Formal donation as the preferred route.ConclusionThe findings indicate informal milk sharing is seen as an inferior alternative to formal milk donation systems. The establishment of formal milk banks is viewed as a way to address the shortcomings of informal sharing.Implications for the ProfessionThe findings have implications for the healthcare field, particularly in improving the experiences of those involved in informal milk sharing. The insights gained from the experiences of informal milk sharers can directly inform and enhance the services provided by formal milk banks.ImpactGiven the growing prevalence of online informal milk sharing, healthcare professionals should enhance their understanding of this practice. However, the practice has remained understudied, particularly in Asian region. This study brings together the experiences of both milk donors and recipients, providing a comprehensive view on the phenomenon.Reporting MethodThe Standards for Reporting Qualitative Research (SRQR).Patient or Public ContributionNo patient or public contribution.
Perceived Impact of COVID‐19 in an Underserved Community: A Natural Language Processing Approach
Authors: Holmes Ashleigh , Sachar Amanjot Singh , Chang Yu‐Ping 
Published: October 2024

ABSTRACTAimTo utilise natural language processing (NLP) to analyse interviews about the impact of COVID‐19 in underserved communities and to compare it to traditional thematic analysis in a small subset of interviews.DesignNLP and thematic analysis were used together to comprehensively examine the interview data.MethodsFifty transcribed interviews with purposively sampled adults living in underserved communities in the United States, conducted from June 2021 to May 2022, were analysed to explore the impact of the COVID‐19 pandemic on social activities, mental and emotional stress and physical and spiritual well‐being. NLP includes several stages: data extraction, preprocessing, processing using word embeddings and topic modelling and visualisation. This was compared to thematic analysis in a random sample of 10 interviews.ResultsSix themes emerged from thematic analysis: The New Normal, Juxtaposition of Emotions, Ripple Effects on Health, Brutal yet Elusive Reality, Evolving Connections and Journey of Spirituality and Self‐Realisation. With NLP, four clusters of similar context words for each approach were analysed visually and numerically. The frequency‐based word embedding approach was most interpretable and well aligned with the thematic analysis.ConclusionThe NLP results complemented the thematic analysis and offered new insights regarding the passage of time, the interconnectedness of impacts and the semantic connections among words. This research highlights the interdependence of pandemic impacts, simultaneously positive and negative effects and deeply individual COVID‐19 experiences in underserved communities.ImplicationsThe iterative integration of NLP and thematic analysis was efficient and effective, facilitating the analysis of many transcripts and expanding nursing research methodology.ImpactWhile thematic analysis provided richer, more detailed themes, NLP captured new elements and combinations of words, making it a promising tool in qualitative analysis.Reporting MethodNot applicable.Patient or Public ContributionNo patient or public contribution.
Blood Pressure Reduction and Changes in Antihypertensive Medication Use Among Patients With Hypertension Who Initiated Sodium‐Glucose Cotransporter‐2 Inhibitors
Authors: An Jaejin , Sim John J. , Zhou Matt M. , Zhou Hui , Choi Soon Kyu , Brettler Jeffrey W. , Ong‐Su Angeline L. , Reynolds Kristi 
Published: October 2024

ABSTRACTSodium‐glucose cotransporter‐2 inhibitors (SGLT2i) have demonstrated a blood pressure (BP) reduction benefit despite other indications for use. We evaluated BP changes and antihypertensive medication use pre‐ and post‐SGLT2i initiation among 12 960 patients with treated hypertension and among subgroups with apparent treatment‐resistant hypertension (aTRH) and/or proteinuria. Post‐SGLT2i initiation, the mean (SD) systolic blood pressure (SBP) was reduced from 133.9 (16.4) to 128.6 (15.5) mmHg and the mean diastolic blood pressure (DBP) was reduced from 70.8 (11.8) to 68.3 (11.3) mmHg among all patients. The mean SBP/DBP reduction was 5.3/2.5, 6.2/2.8, and 6.1/2.9 mmHg among all patients, patients with aTRH, and patients with proteinuria, respectively. Achieved BP < 130/80 mmHg increased by 12.5%, 16.9%, and 11.1% for all patients, patients with aTRH, and patients with proteinuria, respectively. Discontinuation of ≥ 1 antihypertensive medication within 12 months of SGLT2i initiation occurred in 33.4% overall, 47.6% of patients with aTRH, and 38.7% of patients with proteinuria.
Adaptation of the health literacy survey19‐Europe‐Q12 into Turkish culture: A psychometric study
Authors: Terzi Handan , Akca Ayşegül , Ayaz‐Alkaya Sultan 
Published: October 2024

AbstractRationaleMisinformation can lead to adverse outcomes on the health beliefs and behaviors of individuals. Therefore, health literacy skills are needed as a central competency to recognize the trustfulness of health‐related knowledge in any resources. To ensure this, a time‐efficient, skill‐oriented psychometric tools are needed to measure the comprehensive general health literacy level of communities.Aims and ObjectivesThis research was conducted to evaluate the psychometric properties of the 12‐item Health Literacy Survey‐Europe (HLS19‐Q12) regarding Turkish culture.MethodA methodological design was adopted. The population consisted of adult individuals registered to two family health centers in Ankara. The sample was determined based on 5–10 times the number of scale items rule (ntotal = 192). A questionnaire and Health Literacy Survey‐Europe‐Q12 were used to collect data. Language, content and construct validities and internal consistency reliability tests were performed through IBM‐SPSS 25.0 and AMOS 24.0 programs. The content validity was determined via the Davis technique. The construct validity was examined by exploratory (EFA) (n1 = 120) and confirmatory factor analysis (CFA) (n2 = 72). Internal consistency was evaluated using Cronbach's alpha coefficient. Time invariance was evaluated by test‐retest method (nretest = 32) 4 weeks later.ResultsThe mean age was 30.17 ± 10.37 (min. 18‐max. 61). The Kaiser‐Meyer Olkin test result was 0.898, and the Bartlett's Test of Sphericity result was 604.889 (p < 0.001). The model‐fit indices showed good fit. The difference between the first and the second measurements was statistically insignificant (t = −1.659, p = 0.107). The Cronbach's alpha was 0.88.ConclusionsThe HLS19‐Q12‐TR was a valid and reliable measurement tool in determining the health literacy level of the Turkish adult population. As one of the social determinants of health, easy measurement and generating a general health literacy map of the population is considered a necessity.
Exploring the reduction in aquaporin‐4 and increased expression of ciliary neurotrophic factor with the frontal–striatal gliosis induced by chronic high‐fat dietary stress
Authors: Fu Jing‐Ting , Huang Hui‐Ting , Chen Pei‐Chun , Kuo Yu‐Min , Chen Po‐See , Tzeng Shun‐Fen 
Published: October 2024

AbstractHigh‐fat diet (HFD)‐induced obesity induces peripheral inflammation and hypothalamic pathogenesis linking the activation of astrocytes and microglia. Clinical evidence indicates a positive correlation between obesity and psychiatric disorders, such as depression. The connectivity of the frontal‐striatal (FS) circuit, involving the caudate putamen (CPu) and anterior cingulate cortex (ACC) within the prefrontal cortex (PFC), is known for its role in stress‐induced depression. Thus, there is a need for a thorough investigation into whether chronic obesity‐induced gliosis, characterized by the activation of astrocytes and microglia, in these brain regions of individuals with chronic obesity. The results revealed increased S100β+ astrocytes and Iba1+ microglia in the CPu and ACC of male obese mice, along with immune cell accumulation in meningeal lymphatic drainage. Activated GFAP+ astrocytes and Iba1+ microglia were observed in the corpus callosum of obese mice. Gliosis in the CPu and ACC was linked to elevated cleaved caspase‐3 levels, indicating potential neural cell death by chronic HFD feeding. There was a loss of myelin and adenomatous polyposis coli (APC)+ oligodendrocytes (OLs) in the corpus callosum, an area known to be linked with injury to the CPu. Additionally, reduced levels of aquaporin‐4 (AQP4), a protein associated within the glymphatic systems, were noted in the CPu and ACC, while ciliary neurotrophic factor (CNTF) gene expression was upregulated in these brain regions of obese mice. The in vitro study revealed that high‐dose CNTF causing a trend of reduced astrocytic AQP4 expression, but it significantly impaired OL maturation. This pathological evidence highlights that prolonged HFD consumption induces persistent FS gliosis and demyelination in the corpus callosum. An elevated level of CNTF appears to act as a potential regulator, leading to AQP4 downregulation in the FS areas and demyelination in the corpus callosum. This cascade of events might contribute to neural cell damage within these regions and disrupt the glymphatic flow.
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Diverse functions of DEAD‐box proteins in oligodendrocyte development, differentiation, and homeostasis
Authors: Bizen Norihisa , Takebayashi Hirohide 
Published: October 2024

AbstractOligodendrocytes, a type of glial cell in the central nervous system, have a critical role in the formation of myelin around axons, facilitating saltatory conduction, and maintaining the integrity of nerve axons. The dysregulation of oligodendrocyte differentiation and homeostasis have been implicated in a wide range of neurological diseases, including dysmyelinating disorders (e.g., Pelizaeus‐Merzbacher disease), demyelinating diseases (e.g., multiple sclerosis), Alzheimer's disease, and psychiatric disorders. Therefore, unraveling the mechanisms of oligodendrocyte development, differentiation, and homeostasis is essential for understanding the pathogenesis of these diseases and the development of therapeutic interventions. Numerous studies have identified and analyzed the functions of transcription factors, RNA metabolic factors, translation control factors, and intracellular and extracellular signals involved in the series of processes from oligodendrocyte fate determination to terminal differentiation. DEAD‐box proteins, multifunctional RNA helicases that regulate various intracellular processes, including transcription, RNA processing, and translation, are increasingly recognized for their diverse roles in various aspects of oligodendrocyte development, differentiation, and maintenance of homeostasis. This review introduces the latest insights into the regulatory networks of oligodendrocyte biology mediated by DEAD‐box proteins.
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Perceptions and Experiences of Animal‐Assisted Interventions for People Living With Dementia: A Qualitative Evidence Synthesis
Authors: Zhang Dou , Hennessy Marita , Li Qiuxia , Paley Nuala , Paley Gerry , Houghton Catherine 
Published: October 2024

ABSTRACTAimTo synthesise stakeholders' experiences and perceptions of animal‐assisted intervention (AAI) for people with dementia in community care settings.DesignQualitative evidence synthesis.MethodsWe systematically searched Medline, CINAHL, Embase, Scopus, Web of Science, PsycINFO and AgeLine for potentially eligible studies. Thematic synthesis was used to analyse the data from included studies. We assessed the methodological limitations of included studies using an adaptation of the Critical Appraisal Skills Programme checklist and used Confidence in the Evidence from Reviews of Qualitative Research (GRADE‐CERQual) tool to assess confidence in review findings. This review is reported using the ENTREQ checklist.ResultsWe included 14 reports from 11 studies and developed three analytical themes incorporating a gardening analogy: planting–connecting with animals, growing–engaging in AAI and nurturing–making AAI work; and six subthemes: willingness to connect, building relationships, a rich experience, the benefits of AAI, individualised and holistic approach and training and support, with 15 key findings.ConclusionThis review describes people's experiences and perceptions of AAI for people with dementia, and provides recommendations on the development and implementation of AAI, with moderate to high confidence. Nurses need to consider the factors that influence the implementation of AAI identified in this review, to facilitate engagement and long‐term impacts while adopting AAI in community care settings.Implications for the Profession and Patient CareThis review may enhance healthcare professionals' understanding of AAI for people with dementia in community care settings. AAI is a complex intervention that can be delivered in varied manner. A multicomponent, flexible and individualised AAI is important. Additional training and education for staff are needed.Patient or Public ContributionA man with dementia and his wife who share a love of dogs, advised at each step of the review, providing insights and perspectives and contributing as co‐authors.
Adherence to Evidence‐Based Guidelines and Implications When Designing Electronic Documentation for Urinary Catheters
Authors: Janine Bothe , Sheena Lagat , Crellin Rebecca , Hahn Kelly‐Ann , Vicki Patton 
Published: October 2024

ABSTRACTAimThe aim of this study was to investigate the point prevalence and the rate of adherence to evidence‐based guidelines for patients who had indwelling urinary catheters in three Australian acute care hospitals.DesignA cross‐sectional observational design was used.MethodsA multisite cross‐sectional observational design was utilised in three acute hospitals across Australia. Data were collected from each site in a single day directly from observation of the patient, the bedside notes and medical records. The data collected included observations of clinical care and scrutiny of the documentation of the insertion details and catheter care using best practice guidelines.ResultsOf the 1730 patients audited, 47% were female. The mean point prevalence of catheters in situ across three sites was 12.9%. Correct documentation compliance was reported to be, on average, 40%. Documentation was significantly better when a template was available to guide information recorded: this was regardless of whether it was hard copy or electronic. Overall, clinical care compliance with best practices was 77%. Of note for improvement was the fixing of the urinary catheter to the thigh in highly dependent patients.ConclusionIt was identified that there is a need for improvement across all three sites: specifically regarding securement of the urinary catheter to the patient’s thigh within the ICU. In addition, it was identified that there is a need for documentation of the urine bag change in ward areas. Documentation may be improved by incorporating templates into healthcare documentation systems in the future. Further work is needed to ensure nurses are aware of the adverse effects of urinary catheters and thus, the need to adhere to best practice guidelines.Patient or Public ContributionThere has been no patient or public contribution.Reporting MethodWe have adhered to the STROBE guidelines for reporting.
Celebrating the legacy and work of John Schulenberg: Answering the question “Does adolescence matter?”
Authors: Jager Justin , Patrick Megan E. 
Published: October 2024

AbstractDr. John Schulenberg (1957–2023) was a brilliant and internationally recognized developmental scientist. In equal measure, he was an outstanding, dedicated, and generous mentor. Through his scholarship and mentorship, his impact on the fields of adolescent and substance use research will be deep and enduring. The overriding theme of his research was illuminating the importance of adolescence in the life course, which he referred to as “Taking the Long View” on adolescence. John's longstanding motivation for this was to answer the question: “Does adolescence matter?” This special issue, which (in addition to this introduction) includes 14 papers and 2 invited commentaries, is designed to honor his scholarship and impact. For this introduction to the special issue, we divide what it means to “Take the Long View” on adolescence into four major themes: (1) Turning points; (2) Developmental disturbances; (3) Continuity and long‐term developmental connections; and (4) Heterogeneity in the age curve. We describe these four themes, consider how they connect with the overarching question “Does adolescence matter?,” and discuss how the research papers included in this special issue are excellent examples of research inspired by these themes.
Discrimination, critical consciousness, and mental health in American youth of color
Authors: Desmarais Ariane , Christophe N. Keita 
Published: October 2024

AbstractTo resist and cope with oppression, youth of color may use the process of critical consciousness which involves understanding racial injustices (critical reflection), developing motivation to fight these injustices (critical motivation), and taking action to enact sociopolitical change (critical action). However, little is known about how each dimension of critical consciousness affects mental health in adolescents of color. In a sample of 367 ethnically and racially diverse American adolescents of color (age range = 13–17; 68.9% girls, 28.6% boys, and 2.5% gender minority; 84.4% US‐born), we conducted multivariate regressions in Mplus to examine the cross‐sectional links between each critical consciousness dimension (reflection, motivation, and action) and mental health outcomes (anxiety, depression, and stress) over and above the impact of everyday discrimination. We also investigated the interaction between critical consciousness and discrimination in predicting mental health outcomes. Controlling for age, gender, nativity, and social class, we found that discrimination and critical action were both positively associated with anxiety, depression, and stress. For our covariates, girls and gender minority adolescents reported worse outcomes. No interactions were significant. Overall, critical action, while necessary to enact societal change, may have a complex relationship with youth's depression, anxiety, and psychological stress symptoms and warrants careful exploration. Future research should focus on understanding the longitudinal mechanisms of critical action and how we can maximize the benefits by protecting youth from those negative effects.
Identifying the role of siblings in adolescent decision‐making: A developmental processes approach
Authors: Rogers Christy R. , Morgan Derek D. 
Published: October 2024

AbstractAdolescence represents a period of opportunity in decision‐making as developmental motivations and processes shift, particularly in social contexts. Sibling relationships may be especially influential in adolescent decision‐making, as siblings spend a disproportionate amount of time with one another and can affect how adolescents think, feel, and behave. However, the ways in which siblings may shape adolescent decision‐making through psychological, behavioral, and neurological processes, particularly their interactions, are less well known. This review introduces the developmental processes approach to understanding adolescent decision‐making in the sibling context by reviewing patterns in the literature as to how each developmental process in sibling contexts may contribute to adolescent decision‐making. Interdisciplinary collaborations across theories and methods (i.e., surveys, observations, and neuroimaging) can contribute to a more holistic understanding of how siblings may shape adolescent decision‐making, for better and for worse. Further, this approach can inform practice through sibling‐focused prevention programs and other sibling‐focused programming (e.g., government, nonprofit) in promoting adaptive adolescent decision‐making.