bluuebunny/crossref_metadata_2025_split huggingface dataset:
[The difficult management of patients with type 2 diabetes and renal disease: from diagnosis to treatment]
Authors: Pontremoli Roberto , Cappadona Francesca , Solini Anna 
Published: May 2016

The prevalence of type 2 diabetes mellitus and arterial hypertension is on the rise in western countries and chronic kidney disease is certainly one of their most harmful complications. This condition greatly complicates patient management. The clinician needs to wisely identify the best diagnostic algorithm and carefully balance potential risks and benefits of each therapeutic decision.Even when recommended therapeutic targets can be achieved, often a challenging task in clinical practice, residual cardiovascular and renal risk remains unacceptably high for these patients.Here we present the case of a 72-year old woman, with arterial hypertension and diabetes mellitus type 2. Despite the long clinical history of the patient, being treated for over 20 years,blood pressure and metabolic control were not satisfactory. The authors trace the patient’s treatment pathway, following the different clinical questions that led them to the modification of the patient’s therapy. The new therapy is based on chlorthalidone, sitagliptin, a combinationtherapy of ezetimibe / simvastatin, and metformin. [Article in Italian]
Les cheminements de la créativité en traduction
Authors: Stefanink Bernd , Bălăcescu Ioana 
Published: May 2016

La créativité est souvent sciemment écartée de la réflexion traductologique sous prétexte qu’elle « ne se prête pas à une étude systématique » (Gerzymisch-Arbogast et Mudersbach 1998 : 16). Et pourtant elle est le pain quotidien du traducteur. Elle est donc incontournable dans une théorie qui tient compte de la pratique. Nous nous proposons de démontrer la pertinence de l’approche herméneutique dans la gestion de la créativité par un exemple empirique, étudié à l’aide de l’analyse conversationnelle ethnométhodologique, qui nous permet de suivre le cheminement vers une solution créative qui peut paraître osée à première vue, mais qui se voit brillamment légitimée par des recherches récentes en sciences cognitives sur le fonctionnement de notre cerveau.
La transition énergétique entre homéostasie du système et effondrement
Authors: Rudolf Florence 
Published: May 2016

La transition énergétique prétend ouvrir un nouvel horizon dans le paysage français, mais cet horizon est-il à ce point inédit ? Pour en discuter, nous l’inscrivons dans une série dont elle fait partie. Par bien des aspects, les sémantiques qui rythment cette série partagent bien des points, dont le rejet de la figure révolutionnaire et l’affichage d’une certaine confiance dans la capacité de la modernité à faire face aux enjeux écologiques de la fin du XXe et du début du XXIe siècles. Par-delà cette similitude, le repérage des différences laisse entrevoir avec la référence à la transition un tournant plus menaçant qu’il n’y paraît au premier abord. Si la transition énergétique joue encore la carte de l’homéostasie, cette dernière est assombrie par le spectre d’un effondrement socio-écologique majeur qui s’annonce.
Le champ des sustainability transitions : origines, analyses et pratiques de recherche
Authors: Audet René 
Published: May 2016

Le champ des sustainability transitions est peu connu dans les cercles universitaires francophones, demeurant surtout, à ce jour, une affaire européenne. L’objectif de cet article est donc avant tout d’introduire ce champ au monde francophone : il s’agit de présenter les sustainability transitions, ses principales écoles, leurs problématiques théoriques et empiriques, leurs pratiques méthodologiques et leurs critiques. L’article est organisé autour des trois problématiques centrales du champ, soit : les problèmes de l’incertitude, de la complexité et de la réflexivité dans la gouvernance du développement durable, le fort degré de verrouillage des principaux systèmes sociotechniques empêchant leur « transition vers la durabilité », et le défi plus méthodologique du pilotage du changement et des transitions. L’article présente ces trois problématiques en montrant leurs ancrages dans différentes filiations théoriques des sciences sociales et des sciences de l’environnement, et en propose finalement une critique épistémologique et politique qui invite à réfléchir davantage aux conséquences des sustainability transitions sur les transformations actuelles des sociétés dans le contexte des crises écologique et climatique.
Microscopic Raman study of graphene on 4H-SiC two-dimensionally enhanced by surface roughness and gold nanoparticles
Authors: Matsumura Hisatomo , Yanagiya Shin-ichiro , Nagase Masao , Kishikawa Hiroki , Goto Nobuo 
Published: May 2016

AbstractWe present microscopic Raman spectroscopy measurements on single-layer graphene epitaxially grown on 4H-SiC by a thermal decomposition method. We collected spectral data with spatial resolution, which allowed us to obtain two-dimensionally enhanced Raman mapping images. Shallow holes in SiC, which had areas of 5 to 20 µm and depths of 100 nm, enhanced the Raman intensity of the 2D band of graphene. A monolayer of gold nanoparticle (AuNP) aggregates was successfully prepared by dropping and drying a colloidal suspension of AuNPs. The AuNP exhibited 30-fold enhanced the Raman spectra in the wavenumber range of 1550–1700 cm−1. Locally enhanced Raman intensity was also demonstrated using a glass microbead.
Retrospective study on structural neuroimaging in first-episode psychosis
Authors: Coentre Ricardo , Silva-dos-Santos Amilcar , Talina Miguel Cotrim 
Published: May 2016

Background.No consensus between guidelines exists regarding neuroimaging in first-episode psychosis. The purpose of this study is to assess anomalies found in structural neuroimaging exams (brain computed tomography (CT) and magnetic resonance imaging (MRI)) in the initial medical work-up of patients presenting first-episode psychosis.Methods.The study subjects were 32 patients aged 18–48 years (mean age: 29.6 years), consecutively admitted with first-episode psychosis diagnosis. Socio-demographic and clinical data and neuroimaging exams (CT and MRI) were retrospectively studied. Diagnostic assessments were made using the Operational Criteria Checklist +. Neuroimaging images (CT and MRI) and respective reports were analysed by an experienced consultant psychiatrist.Results.None of the patients had abnormalities in neuroimaging exams responsible for psychotic symptoms. Thirty-seven percent of patients had incidental brain findings not causally related to the psychosis (brain atrophy, arachnoid cyst, asymmetric lateral ventricles, dilated lateral ventricles, plagiocephaly andfalx cerebricalcification). No further medical referral was needed for any of these patients. No significant differences regarding gender, age, diagnosis, duration of untreated psychosis, in-stay andcannabisuse were found between patients who had neuroimaging abnormalitiesversusthose without.Discussion.This study suggests that structural neuroimaging exams reveal scarce abnormalities in young patients with first-episode psychosis. Structural neuroimaging is especially useful in first-episode psychosis patients with neurological symptoms, atypical clinical picture and old age.
Persistence of dicamba residue in harvested soybeans
Authors: Henry Jerri Lynn , Lin Chung‐Ho , Weirich Jason W. , Smeda Reid J. 
Published: September 2024

AbstractAdoption of dicamba‐tolerant soybeans contributed to widespread reports of chemical trespassing on adjacent, sensitive soybeans. Reports of the impact of dicamba on sensitive soybeans (Glycine max L.) have been well documented; however, the potential for dicamba carryover into harvested beans from sensitive plants has largely been overlooked. Field trials in central Missouri focused on assessing the injury and yield response of sensitive soybeans to concentrations of dicamba as low as 0.25% of the use rate (10 µL L−1 dicamba). In both 2018 and 2019, dicamba‐sensitive soybeans were planted in conventional row spacing and treated with 10–300 µL L−1 dicamba at both V3 and R1 soybeans. Dicamba symptoms were visible in less than 7 days after application (DAA); significant injury was observed at 10 µL L−1 and persisted through the duration of the study (28 DAA). Injury levels reached almost 50% with 300 µL L−1 dicamba. Step‐wise increases in soybean yield losses occurred with increasing dicamba concentrations and reached 50% with 300 µL L−1 dicamba. Yield losses were up to 10% greater for R1 versus V3 soybeans treated with the same dicamba concentration. Dicamba residues in bean tissue ranged from 0.72 to 0.81 mg kg−1 for 150 to 300 µL L−1 dicamba, and residues were similar for beans at both V3 and R1. Dicamba persisted in beans harvested up to 122 days after plant exposure to dicamba. Although dicamba residues were within limits established by the EPA (10 mg kg−1), residues exceeded that allowed in marketed, organic soybeans (0.5 mg kg−1).
Enhancement of the Potential Window of Ppy Electrodes in the Presence of a Bis(Oxamato) Nickel(II) Complex for High‐Performance Supercapacitor
Authors: Pesqueira Camila , Hryniewicz Bruna M. , Klobukoski Vanessa , Weheabby Saddam , Kanoun Olfa , Rüffer Tobias , Pašti Igor A. , Vidotti Marcio 
Published: September 2024

AbstractEnhancing the supercapacitors’ performance relies on the increased capacitance and voltage window, which are the current key challenges for developing new materials. In this study, the mononuclear NiII‐bis(oxamato) complex ([nBu4N]2[Ni(opba)], 1) has been synthesized and used as a template in polypyrrole (PPy) based conductive polymer as a novel electrode material for supercapacitor applications. The surface and structural properties of PPy and PPy/1 electrodes were studied using SEM and TEM to elucidate their interactions. The results of characterization techniques revealed that complex 1 altered the morphology, creating a prominent three‐dimensional globular structure in the PPy/1 hybrid material without significant chemical modification. The electrochemical properties of PPy and PPy/1 were investigated by CV, EIS, and GCD analyses. The PPy/1 electrode demonstrated intense pseudocapacitive behavior, showing a significantly widened potential window and increased current compared to the PPy electrode, resulting in enhanced energy storage capacity within the material. This improvement was evaluated by testing a symmetric supercapacitor in a coin cell architecture with an alginate‐based gel acting as both electrolyte and separator. The maximum specific cell capacitance reached 41.6 F g−1 at a current density of 0.2 A g−1, with a remarkable capacity retention of 97 % after 1000 galvanostatic charge/discharge cycles.
Intensification of biogas production from rice straw using anaerobic digestion based on pre‐treatment with ultrasound
Authors: Gandhi Sudhir S. , Gogate Parag R. , Patil Abhijeet D. 
Published: September 2024

AbstractThe current work illustrates a novel method of pre‐treating rice straw using ultrasound (US) as well as using ultrasound coupled with anaerobic digestion (AD) to intensify biogas production. The primary objectives were to evaluate the effectiveness of ultrasound in increasing the utilization of rice straw and to optimize the conditions for maximum biogas yield. Important parameters such as ultrasonic power (0.2–1 W/mL), duty cycle (20%–80%), and substrate loading (2%–10% w/v) were varied to understand their effects during pre‐treatment. The results showed that the maximum increase in soluble chemical oxygen demand (sCOD), with a final value of 13,500 mg/L (an increase of 64.63%), was achieved under optimum conditions of ultrasonic power of 0.4 W/mL, a duty cycle of 50%, and a substrate loading of 6% w/v. Additionally, the study evaluated the effect of low‐intensity US exposure during AD with pre‐treated rice straw at varying irradiation times (10–30 min) and duty cycles (20%–60%). The optimal conditions of ultrasonic time of 20 min and a duty cycle of 50% resulted in nearly four times higher biogas generation compared to untreated samples. The current research successfully demonstrates the efficient use of US in the feedstock pre‐treatment and also in AD process, leading to significant intensification in biogas production within a shorter time frame.
Design, analysis, and experimental validation of proposed dual gain pseudo squared buck–boost converter
Authors: Singh Shubham Kumar , Agarwal Anshul 
Published: September 2024

AbstractThis study presents a novel approach to improve the efficiency and performance of a new proposed buck–boost converter. The buck–boost converter allows for voltage step‐up or step‐down operations, making it suitable for wide range applications. The proposed converter design incorporates innovative circuitry to enhance the overall system efficiency. Based on the findings, a new buck–boost converter topology is introduced, which offers improved voltage regulation, reduced losses, and increased power conversion efficiency compared to traditional converter designs. Simulation studies and experimental validations are conducted to assess the performance of the proposed new buck–boost converter. The results demonstrate significant improvements in power output and system stability of proposed converter compared to conventional converter configurations.
Cytokine and chemokine receptor profiles in adipose tissue vasculature unravel endothelial cell responses in HIV
Authors: Obare Laventa M. , Priest Stephen , Ismail Anas , Mashayekhi Mona , Zhang Xiuqi , Stolze Lindsey K. , Sheng Quanhu , Nthenge Kisyua , Vue Zer , Neikirk Kit , Beasley Heather K. , Gabriel Curtis , Temu Tecla , Gianella Sara , Mallal Simon A. , Koethe John R. , Hinton Antentor , Bailin Samuel S. , Wanjalla Celestine N. 
Published: September 2024

AbstractChronic systemic inflammation significantly increases myocardial infarction risk in people living with HIV (PLWH). Endothelial cell dysfunction disrupts vascular homeostasis regulation, increasing the risk of vasoconstriction, inflammation, and thrombosis, contributing to cardiovascular disease. We aimed to characterize endothelial cell (EC) chemokines, cytokine, and chemokine receptors of PLWH, hypothesizing that in our cohort, glucose intolerance contributes to their differential expression implicated in endothelial dysfunction. Using single‐cell transcriptomic analysis, we phenotyped chemokine and cytokine receptor expression on arterial ECs, capillary ECs, venous ECs, and vascular smooth muscle cells (VSMCs) in subcutaneous adipose tissue of 59 PLWH with and without glucose intolerance. Our results show that arterial and capillary ECs express significantly higher interferon and tumor necrosis factor (TNF) receptors than venous ECs and VSMCs. Venous ECs exhibited more interleukin (IL)1R1 and ACKR1 receptors, and VSMCs showed significant IL6R expression than arterial and capillary ECs. When stratified by group, arterial ECs from PLWH with glucose intolerance expressed significantly higher IL1R1, IL6R, CXCL12, CCL14, and ICAM2 transcripts than arterial ECs from PLWH without diabetes. Of the different vascular cell types studied, arterial ECs as a proportion of all ECs in adipose tissue were positively correlated with plasma fasting blood glucose. In contrast, venous ECs and VSMCs were positively correlated with plasma IL6. To directly assess the effect of plasma from PLWH on endothelial function, we cultured human arterial ECs (HAECs) in plasma‐conditioned media from PLWH and performed bulk RNA sequencing. Plasma from PLWH stimulated ECs with the upregulation of genes that enrich for the oxidative phosphorylation and the TNF‐α via NFK‐β pathways. In conclusion, ECs in PLWH show heterogeneous cytokine and chemokine receptor expression, and arterial ECs were the most influenced by glucose intolerance. Further research must explicate cytokine and chemokine roles in EC dysfunction and identify biomarkers for disease progression and therapeutic response.
Attachment representations in pre‐adolescents at familial high risk of schizophrenia or bipolar disorder and population‐based controls—Characteristics of attachment from middle childhood to pre‐adolescence, and its relation to parental functioning and child mental disorder
Authors: Krantz Mette Falkenberg , Gregersen Maja , Veddum Lotte , Hjorthøj Carsten , Prøsch Åsa Kremer , Ohland Jessica , Brandt Julie Marie , Rohd Sinnika Birkehøj , Knudsen Christina Bruun , Andreasen Anna Krogh , Hemager Nicoline , Greve Aja , Mors Ole , Nordentoft Merete , Psouni Elia , Thorup Anne A. E. 
Published: September 2024

AbstractBackgroundDevelopment of secure attachment is crucial to establish and maintain healthy relationships with others throughout life. For parents with schizophrenia or bipolar disorder, challenged parental functioning may compromise the sensitive caregiving needed to establish secure child attachment. We aimed to examine pre‐adolescent attachment, predictors related to caregiving, and middle childhood attachment predictors of pre‐adolescent mental disorders.MethodsIn a population‐based nationwide cohort of 522 children of parents with schizophrenia or bipolar disorder and population‐based controls, The Secure Base Script Test was used to assess attachment security at age 11 (N = 409). Parental caregiving and functioning were assessed with the Personal and Social Performance Scale and MC‐HOME (age 7) and child mental disorder with K‐SADS‐PL (age 7 and 11). Story Stem Assessment Profile was used for age 7 attachment.ResultsWe found no differences between risk and control groups in prevalence of pre‐adolescent secure attachment. Parental level of functioning and attachment security at age 7 significantly predicted more rich secure base content at age 11. Level of age 7 disorganization significantly predicted presence of mental disorder at age 11.ConclusionsOverall, attachment of children at familial risk of schizophrenia or bipolar disorder did not differ from that of controls. Instead, parental functioning in middle childhood predicts pre‐adolescent attachment, and may therefore serve as a focus for supporting healthy attachment development. Middle childhood disorganization might serve as a predictor of pre‐adolescent mental disorder if other studies confirm our findings, and awareness hereof may be relevant for guiding intervention to support mental development.
Mediation of the influence of mindfulness on academic buoyancy by academic hope: A two‐wave longitudinal study
Authors: Satıcı Seydi Ahmet , Kütük Hasan , Okur Sinan 
Published: September 2024

AbstractEducational activities are significant in that they have an important place in the life of the individual and support mental health. In this study, the relationship between mindfulness and academic buoyancy and the mediating role of academic hope were examined in a longitudinal research study. Data were collected from 287 Turkish university students who participated in the study at 4‐month intervals. An autoregressive analysis of the cross‐lagged panel model for a half‐longitudinal design was used to test the role of academic hope as a mediator in the relationship between mindfulness and academic buoyancy. The results revealed the direct effect of mindfulness on academic hope and academic buoyancy. In addition, academic hope was found to have a mediating effect on the relationship between mindfulness and academic buoyancy. It was, therefore, concluded that improving mindfulness practices may benefit people from both an academic and spiritual perspective.
Reusable Specification Patterns for Verification of Resilience in Autonomous Hybrid Systems
Authors: Adelt Julius , Mensing Robert , Herber Paula 
Published: September 2024

AbstractAutonomous hybrid systems are systems that combine discrete and continuous behavior with autonomous decision-making, e.g., using reinforcement learning. Such systems are increasingly used in safety-critical applications such as self-driving cars, autonomous robots or water supply systems. Thus, it is crucial to ensure their safety and resilience, i.e., that they function correctly even in the presence of dynamic changes and disruptions. In this paper, we present an approach to obtain formal resilience guarantees for autonomous hybrid systems using the interactive theorem prover KeYmaera X. Our key ideas are threefold: First, we derive a formalization of resilience that is tailored to autonomous hybrid systems. Second, we present reusable patterns for modeling stressors, detecting disruptions, and specifying resilience as a service level response in the differential dynamic logic (d$$\mathcal {L}$$
L
). Third, we combine these concepts with an existing approach for the safe integration of learning components using hybrid contracts, and extend it towards dynamic adaptations to stressors. By combining reusable patterns for stressors, observers, and adaptation contracts for learning components, we provide a systematic approach for the deductive verification of resilience of autonomous hybrid systems with reduced specification effort. We demonstrate the applicability of our approach with two case studies, an autonomous robot and an intelligent water distribution system.
A Case Study on Formal Equivalence Verification Between a C/C++ Model and Its RTL Design
Authors: Raia Gaetano , Rigano Gianluca , Vincenzoni David , Martina Maurizio 
Published: September 2024

AbstractIn the field of communication system products, most datapath Digital Signal Processing algorithms are initially developed at a high-level in MATLAB® or C/C++. Subsequently, design engineers use these models as a reference for implementing Register Transfer Level designs. The conventional approach to verify their equivalence involves extensive Universal Verification Methodology dynamic simulations, which can last for months and require significant verification efforts. However, some elusive errors might still occur because it is infeasible to explore all input combinations with this method. On the other hand, Formal Equivalence Verification aims to verify that a Register Transfer Level design is functionally equivalent to the reference high-level C/C++ model across all possible legal states. With recent advancements in formal solver technology, Formal Equivalence Verification provides a distinct benefit by using mathematical methods to ensure that the Register Transfer Level (timed) matches the original high-level C/C++ model (untimed). This drastically reduces the verification time and ensures the exhaustive coverage of the design state space. This paper presents an in-depth exploration of complex Finite State Machine with datapath verification, specifically focusing on Multiplier-Accumulator, Tone Generator, and Automatic Gain Control, by employing the formal equivalence methodology. Although these signal processing blocks were previously verified throughout Universal Verification Methodology dynamic simulations, Formal Equivalence Verification was able to identify hard-to-find bugs in just a few weeks by utilizing the new workflow, thereby streamlining the verification process.
Einleitung
Authors: Kuhn Andrea 
Published: September 2024

ZusammenfassungEinige deutsche Bundesländer haben in den letzten Jahren Pflegekammern errichtet, sie ermöglichen der Profession Pflege erstmals ihre Selbstverwaltung. Kammerrecht ist Länderrecht, es obliegt jedem einzelnen Bundesland, sich für die Errichtung von Kammern als berufliche Selbstverwaltungsorgane zu entscheiden. Als heilberufliche Körperschaften des öffentlichen Rechts leisten Pflegekammern einen Beitrag zur Sicherung der gesundheitlichen Versorgung der Bevölkerung. Dieses Mandat erteilen die Bundesländer der Profession Pflege qua Gesetzgebung. Das Aufgabenportfolio von Pflegekammern umfasst auch das Thema Ethik. Allerdings mangelt es bis heute an Konkretisierung: Weder ist klar, was genau mit Ethik gemeint ist, noch welches Mandat sich daraus für Pflegekammern ableitet und mit welchen Interventionen es zu füllen wäre. Die Studie unternimmt die wissenschaftliche Entwicklung einer Programmtheorie der nötigen Interventionen des ethischen Mandats der Pflegekammer, kurz: eine Programmtheorie für Ethik in Pflegekammern.