bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mass and p-factor of the Type II Cepheid OGLE-LMC-T2CEP-098 in a Binary System∗
Authors: Pilecki Bogumił , Gieren Wolfgang , Smolec Radosław , Pietrzyński Grzegorz , Thompson Ian B. , Anderson Richard I. , Bono Giuseppe , Soszyński Igor , Kervella Pierre , Nardetto Nicolas , Taormina Mónica , Stȩpień Kazimierz , Wielgórski Piotr 
Published: June 2017

Abstract
We present the results of a study of the type II Cepheid (P
puls = 4.974 days) in the eclipsing binary system OGLE-LMC-T2CEP-098 (P
orb = 397.2 days). The Cepheid belongs to the peculiar W Vir group, for which the evolutionary status is virtually unknown. It is the first single-lined system with a pulsating component analyzed using the method developed by Pilecki et al. We show that the presence of a pulsator makes it possible to derive accurate physical parameters of the stars even if radial velocities can be measured for only one of the components. We have used four different methods to limit and estimate the physical parameters, eventually obtaining precise results by combining pulsation theory with the spectroscopic and photometric solutions. The Cepheid radius, mass, and temperature are

,

, and

, respectively, while its companion has a similar size (

), but is more massive (

) and hotter (9500 K). Our best estimate for the p-factor of the Cepheid is

. The mass, position on the period–luminosity diagram, and pulsation amplitude indicate that the pulsating component is very similar to the Anomalous Cepheids, although it has a much longer period and is redder in color. The very unusual combination of the components suggest that the system has passed through a mass-transfer phase in its evolution. More complicated internal structure would then explain its peculiarity.
The Identification of the White Dwarf Companion to the Millisecond Pulsar J2317+1439
Authors: Dai S. , Smith M. C. , Wang S. , Okamoto S. , Xu R. X. , Yue Y. L. , Liu J. F. 
Published: June 2017

Abstract
We report the identification of the optical counterpart to the companion of the millisecond pulsar J2317+1439. At the timing position of the pulsar, we find an object with

,

, and

. The magnitudes and colors of the object are consistent with a white dwarf (WD). Compared with WD cooling models, we estimate that it has a mass of

, an effective temperature of

K, and a cooling age of 10.9 ± 0.3 Gyr. Combining our results with published constraints on the orbital parameters obtained through pulsar timing, we estimate the pulsar mass to be

. Although the constraint on the pulsar mass is still weak, there is a significant possibility that the pulsar could be more massive than two solar masses.
Condensation of Halo, Circumgalactic, and Intergalactic Gas onto Massive High-velocity Clouds
Authors: Gritton Jeffrey A. , Shelton Robin L. , Galyardt Jason E. 
Published: June 2017

Abstract
High-velocity clouds (HVCs) hydrodynamically interact with their surroundings. In scenarios with small clouds, the net result is erosion of the HVC, but in scenarios with large, massive clouds, it is capture and cooling of environmental gas by the cloud. In order to examine these effects over long periods of time, we made detailed three-dimensional hydrodynamic FLASH simulations of massive HVCs (1.35 × 105
M
☉ to 1.35 × 108
M
☉) traveling through hot, low-density media like that in the extended Galactic halo, circumgalactic media, and intergalactic space for at least 200 Myr. By setting the metallicity of the clouds to differ from that of the ambient gas, we were able to track the transfer of material between the two media. We found that massive clouds condense substantial amounts of ambient gas, up to 100% of their initial mass in certain cases. This gas cools to temperatures below 1.0 × 104 K, but retains some high ions. The amount of condensed gas depends on the cloud mass, the ambient density, and the cloud density and temperature, but apparently not on the velocity. We discuss the ramifications for cloud survivability and for the transport of halo, circumgalactic, and intergalactic gas to the disk of the Galaxy aboard massive HVCs.
VLA Survey of Dense Gas in Extended Green Objects: Prevalence of 25 GHz Methanol Masers
Authors: Towner A. P. M. , Brogan C. L. , Hunter T. R. , Cyganowski C. J. , McGuire B. A. , Indebetouw R. , Friesen R. K. , Chandler C. J. 
Published: June 2017

Abstract
We present ∼1″–4″ resolution Very Large Array (VLA) observations of four CH3OH

-E 25 GHz transitions (J = 3, 5, 8, 10) along with the 1.3 cm continuum toward 20 regions of active massive star formation containing Extended Green Objects (EGOs), 14 of which we have previously studied with the VLA in the Class I 44 GHz and Class II 6.7 GHz maser lines. Sixteen regions are detected in at least one 25 GHz line (J = 5), with 13 of 16 exhibiting maser emission. In total, we report 34 new sites of CH3OH maser emission and 10 new sites of thermal CH3OH emission, significantly increasing the number of 25 GHz Class I CH3OH masers observed at high angular resolution. We identify probable or likely maser counterparts at 44 GHz for all 15 of the 25 GHz masers for which we have complementary data, providing further evidence that these masers trace similar physical conditions despite uncorrelated flux densities. The sites of thermal and maser emission of CH3OH are both predominantly associated with the 4.5 μm emission from the EGO, and the presence of thermal CH3OH emission is accompanied by 1.3 cm continuum emission in 9 out of 10 cases. Of the 19 regions that exhibit 1.3 cm continuum emission, it is associated with the EGO in 16 cases (out of a total of 20 sites), 13 of which are new detections at 1.3 cm. Twelve of the 1.3 cm continuum sources are associated with 6.7 GHz maser emission and likely trace deeply embedded massive protostars.
Comparing parameterized versus measured microphysical properties of tropical convective cloud bases during the ACRIDICON–CHUVA campaign
Authors: Braga Ramon Campos , Rosenfeld Daniel , Weigel Ralf , Jurkat Tina , Andreae Meinrat O. , Wendisch Manfred , Pöhlker Mira L. , Klimach Thomas , Pöschl Ulrich , Pöhlker Christopher , Voigt Christiane , Mahnke Christoph , Borrmann Stephan , Albrecht Rachel I. , Molleker Sergej , Vila Daniel A. , Machado Luiz A. T. , Artaxo Paulo 
Published: June 2017

Abstract. The objective of this study is to validate parameterizations that were recently developed for satellite retrievals of cloud condensation nuclei supersaturation spectra, NCCN(S), at cloud base alongside more traditional parameterizations connecting NCCN(S) with cloud base updrafts and drop concentrations. This was based on the HALO aircraft measurements during the ACRIDICON–CHUVA campaign over the Amazon region, which took place in September 2014. The properties of convective clouds were measured with a cloud combination probe (CCP), a cloud and aerosol spectrometer (CAS-DPOL), and a CCN counter onboard the HALO aircraft. An intercomparison of the cloud drop size distributions (DSDs) and the cloud water content (CWC) derived from the different instruments generally shows good agreement within the instrumental uncertainties. To this end, the directly measured cloud drop concentrations (Nd) near cloud base were compared with inferred values based on the measured cloud base updraft velocity (Wb) and NCCN(S) spectra. The measurements of Nd at cloud base were also compared with drop concentrations (Na) derived on the basis of an adiabatic assumption and obtained from the vertical evolution of cloud drop effective radius (re) above cloud base. The measurements of NCCN(S) and Wb reproduced the observed Nd within the measurements uncertainties when the old (1959) Twomey's parameterization was used. The agreement between the measured and calculated Nd was only within a factor of 2 with attempts to use cloud base S, as obtained from the measured Wb, Nd, and NCCN(S). This underscores the yet unresolved challenge of aircraft measurements of S in clouds. Importantly, the vertical evolution of re with height reproduced the observation-based nearly adiabatic cloud base drop concentrations, Na. The combination of these results provides aircraft observational support for the various components of the satellite-retrieved methodology that was recently developed to retrieve NCCN(S) under the base of convective clouds. This parameterization can now be applied with the proper qualifications to cloud simulations and satellite retrievals.
Aerosol effects on the development of cumulus clouds over the Tibetan Plateau
Authors: Zhou Xu , Bei Naifang , Liu Hongli , Cao Junji , Xing Li , Lei Wenfang , Molina Luisa T. , Li Guohui 
Published: June 2017

Abstract. The aerosol–cloud interaction over the Tibetan Plateau has been investigated using a cloud-resolving weather research and forecasting model with a two-moment bulk microphysical scheme including aerosol effects on cloud condensation nuclei and ice nuclei. Two types of cumulus clouds with a similar convective available potential energy, occurring over the Tibetan Plateau (Cu-TP) and North China Plain (Cu-NCP) in August 2014, are simulated to explore the response of convective clouds to aerosols. A set of aerosol profiles is used in the simulations, with the surface aerosol number concentration varying from 20 to 9000 cm−3 and the sulfate mass concentration varying from 0.02 to 9.0 µg cm−3. Increasing aerosol concentrations generally enhances the cloud core updraft and maximum updraft, intensifying convections in Cu-TP and Cu-NCP. However, the core updraft is much stronger in Cu-TP than Cu-NCP, because of the early occurrence of the glaciation process in Cu-TP that is triggered at an elevation above 4000 m. The precipitation increases steadily with aerosol concentrations in Cu-NCP, caused by the suppression of the warm rain but occurrence of efficient mix-phased precipitation due to the reduced cloud droplet size. The precipitation in Cu-TP also increases with aerosol concentrations, but the precipitation enhancement is not substantial compared to that in Cu-NCP with high aerosol concentrations. The aerosol-induced intensification of convections in Cu-TP not only facilitates the precipitation but also transports more ice-phase hydrometeors into the upper troposphere to decrease the precipitation efficiency. Considering the very clean atmosphere over the Tibetan Plateau, elevated aerosol concentrations can remarkably enhance convections due to its specific topography, which not only warms the middle troposphere to influence the Asian summer monsoon but also delivers hydrometeors into the upper troposphere to allow more water vapor to travel into the lower stratosphere.
Partial replacement of board-certified specialist-grade physicians with emergency medicine trainees in a busy emergency department: Lack of adverse effect on time to physician
Authors: Pathan Sameer A. , Bhutta Zain A. , Moinudheen Jibin , Jenkins Dominic , Farook Saleem , Qureshi Isma , George Pooja , Irfan Furqan B. , Al Khal Abdul Latif , Thomas Stephen H. 
Published: June 2017

Objectives: Standard emergency department (ED) operation goals include minimization of the time interval between patients' initial ED presentation and initial emergency physician (EP) evaluation. Following up on previous work defining factors influencing the “time to physician” (tMD) in a busy ED, the current study was undertaken to evaluate whether tMD was adversely impacted by the ED's partial replacement of specialist-grade EPs with emergency medicine (EM) trainees (at the resident and fellow level). Methods: This retrospective study was conducted for four months (September–December 2015) using an ED administrative database (EDAD) in an urban academic tertiary ED with an annual census of approximately 500,000; during the four study months, the ED census was 165,969. To minimize confounding by time of day and related factors, data analysis focused solely on the “day shift” (0600–1400) of each of the study period's 122 days. EDAD data were combined with EP rostering data to generate a multivariate linear regression model that assessed the dependent variable tMD, for significant changes associated with increasing proportion – not necessarily always the same as increasing the absolute number of trainees (i.e., summed residents and fellows as a total percent of all on-duty EPs). There were trainees in the study ED throughout the study, but the trainee numbers as a proportion of the overall physician staffing fluctuated, thus providing a basis for analysis. The model adjusted for covariates previously demonstrated to impact tMD at the study center. Analyses were conducted with Stata 14MP, with statistical significance defined at p < 0.05 and confidence intervals (CIs) reported at the 95% level. Results: In an acceptable regression model that adjusted for multiple parameters influencing tMD, the introduction of a covariate representing the proportion of on-duty trainee physicians was very small in magnitude (β estimate 0.07, 95% CI − 0.16 to 0.30) and not statistically significant (p = 0.53). Conclusions: A multivariate analysis adjusting for variables contributing to tMD showed no indication of adverse tMD impact from partial replacement of board-certified specialist-grade EPs with EM trainees given adequate supervision by properly trained faculty.
Agression sexuelle et thérapie traditionnelle : essai d’expertise et de prise en charge ethnopsychanalytique d’une adolescente africaine migrante victime d’abus sexuels
Authors: Aboudé Louis Serge 
Published: June 2017

Dans cet article, nous interrogerons en trois étapes certains faits ambigus rencontrés par des professionnels au cours d’une pratique en clinique transculturelle. Le premier pas questionne l’interculturalité des concepts et les réactions du migrant, qui mettraient à mal le professionnel et l’obligeraient à se décentrer, à penser sa position clinique et, enfin, à travailler le contre-transfert culturel négatif qui en résulterait. La deuxième étape concernera l’indication proprement dite du soin dans ce contexte et nous ferons le choix de mobiliser pour ce faire l’ethnopsychanalyse. Enfin, il s’agira de réfléchir aux perspectives cliniques et psychopathologiques qui émergent du matériel clinique récolté à la suite d’une telle rencontre.
Nous poserons ainsi les jalons d’une conceptualisation en psychopathologie de famille démigrante ou remigrante en souffrance, ou encore de patient démigrant ou remigrant, en s’appuyant sur le cas d’une adolescente victime d’abus sexuels. Nous verrons que c’est à l’occasion d’un retour de la famille au Cameroun et de l’intrusion d’une pratique traditionnaliste par la grand-mère (test traditionnel de virginité) qu’un premier événement traumatique vécu en France fera retour après-coup. Cette situation mettrait en lumière de manière particulièrement crue la difficile question du choc toujours possible entre deux cultures thérapeutiques.
Détresse et anxiété chez les étudiants du collégial et recours aux services d’aide socioaffectifs
Authors: Gosselin Marc-André , Ducharme Robert 
Published: June 2017

Cette étude a été réalisée auprès de 12 208 cégépiens du régulier, inscrits à la session d’automne 2014 et provenant de huit cégeps situés dans différentes régions du Québec. Elle mesure l’ampleur des besoins socioaffectifs des répondants et l’utilisation des services d’aide qui leur sont offerts. Les résultats indiquent que les trois quarts des répondants ont recours à de tels services d’aide pour des problèmes autres que scolaires. Les principaux motifs de ce recours sont la satisfaction, la curiosité et la souffrance. Les résultats montrent aussi que 17,4 % des répondants ont ressenti beaucoup ou énormément de détresse et que 35,1 % ont éprouvé souvent ou tout le temps de l’anxiété. Les principaux facteurs explicatifs de la détresse et de l’anxiété sont les conflits familiaux, la pression liée au rendement scolaire, l’intimidation et les pensées suicidaires. Ainsi, 29,3 % disent qu’ils ont vécu beaucoup ou énormément de détresse à l’égard des conflits familiaux; 33,3 % ont éprouvé beaucoup ou énormément de pression liée à la performance scolaire; 11,9 % ont ressenti beaucoup ou énormément de détresse liée à l’intimidation et 18,3 % des répondants affirment avoir eu des pensées suicidaires et parmi eux, 7,3 % disent en avoir eues souvent ou tout le temps. Enfin, certains préjugés à l’égard de la santé mentale apparaissent comme un frein significatif à l’utilisation des ressources d’aide.
Mobilizing STING Pathway via a Cationic Liposome to Enhance Doxorubicin‐Induced Antitumor Immunity
Authors: Liu Xiaochen , Zhao Zhiwen , Xu Xiaoxuan , Yi Wenzhe , Yan Dan , Wang Dangge , Li Yaping 
Published: October 2024

AbstractThe efficacy of anthracycline, such as doxorubicin (DOX), is facilitated by cancer cell‐intrinsic type I interferon (IFN‐I) signaling through the induction of immune responses. However, weak and chronic IFN‐I responses from rounds of chemotherapy lead to resistance against DNA damage and acquired resistance to the therapy. An exogenous supply of IFN‐I can improve the chemotherapeutic responses. Herein, a library of cationic liposomes is developed for the optimization of 1, 2‐dioleoyl‐3‐trimethylammonium‐propane (DOTAP) proportions to enhance the lysosome escape and tumor distribution of the stimulator of interferon genes (STING) agonist 2′,3′‐cyclic guanosine monophosphate‐adenosine monophosphate (cGAMP) and DOX. The cationic liposomes with 8% DOTAP release cGAMP into the cytoplasm and increase the concentration of DOX in the tumor by 1.5 times compared with the free drug. Upon accumulation at the tumor site, the optimized liposomes induce immunogenic cell death (ICD) and stimulate the STING signaling, thereby improving the production of endogenous IFN‐I and promoting dendritic cell maturation to mobilize T cell immunity. The tumor growth inhibition rate is 86%, and the median survival time is 1.6‐fold prolonged. This study offers a strategy to enhance the DOX‐induced immune response by activating the STING pathway to supply IFN‐I.
A Flexible Adaptive Lasso Cox Frailty Model Based on the Full Likelihood
Authors: Hohberg Maike , Groll Andreas 
Published: October 2024

ABSTRACTIn this work, a method to regularize Cox frailty models is proposed that accommodates time‐varying covariates and time‐varying coefficients and is based on the full likelihood instead of the partial likelihood. A particular advantage of this framework is that the baseline hazard can be explicitly modeled in a smooth, semiparametric way, for example, via P‐splines. Regularization for variable selection is performed via a lasso penalty and via group lasso for categorical variables while a second penalty regularizes wiggliness of smooth estimates of time‐varying coefficients and the baseline hazard. Additionally, adaptive weights are included to stabilize the estimation. The method is implemented in the R function coxlasso, which is now integrated into the package PenCoxFrail, and will be compared to other packages for regularized Cox regression.
A phase I clinical trial of sonodynamic therapy combined with radiotherapy for brainstem gliomas
Authors: Huangfu Linkuan , Zha Boya , Li Peihong , Wang Long , Liu Xiaohao , Cui Haiyang , Li Yuxin , Wu Jingjing , Shi Shuling , Yang Yuchuan , Sun Xiaocong , Gao Shibo , Li Huizhen , Yang Daoke , Zheng Yingjuan 
Published: October 2024

AbstractBrainstem gliomas (BSGs) are a class of clinically refractory malignant tumors for which there is no uniform and effective treatment protocol. Ultrasound and radiation can activate hematoporphyrin and produce sonodynamic and radiodynamic effects to kill cancer cells. Therefore, we conducted the first phase I clinical trial of sonodynamic therapy (SDT) combined with radiotherapy (RT) for the treatment of BSGs to verify its safety and efficacy. We conducted a study of SDT combined with RT in 11 patients with BSGs who received SDT and RT after hematoporphyrin administration. Magnetic resonance imaging was performed during this period to assess the tumor, and adverse events were recorded. All adverse events recorded were grade 1–2; no grade 3 or more serious adverse events were observed. Treatment was well tolerated, and no dose‐limiting toxicities were observed. There were no treatment‐related deaths during the course of treatment. 8 of 11 patients (72.7%) maintained stable disease, 2 (18.2%) achieved partial response, and the tumors were still shrinking as of the last follow‐up date. The median progression‐free survival (PFS) for patients was 9.2 (95% confidence interval [CI] 6.2–12.2) months, and the median overall survival (OS) was 11.7 (95% CI 9.6–13.8) months. Therefore, SDT combined with RT has a favorable safety and feasibility and shows a preliminary high therapeutic potential.
Incidence of Pediatric to Adult Transition Among Tracheotomy Patients
Authors: Lee Rebecca , Chorney Stephen R. , Kou Yann Fuu , Wang Cynthia S. , Brooks Rebecca , Johnson Romaine F. 
Published: October 2024

ObjectiveTo estimate the incidence and identify predictors of pediatric tracheostomy patients who transition into adulthood with a tracheostomy.MethodsWe conducted a retrospective analysis of pediatric tracheostomy patients treated at a single tertiary care pediatric hospital between 2009 and 2022. Patient demographics, comorbidities, tracheostomy outcomes, including decannulation and mortality rates, and the status of those alive with a tracheostomy at adulthood were compared.ResultsOf the 663 children who underwent a tracheostomy, 103 (15.5%) would have surpassed 18 years by September 1, 2023. Detailed breakdown: 26 (25%) were alive with a tracheostomy, 35 (34%) had been decannulated, 25 (24%) had passed away, and 17 (16.5%) were lost to follow‐up. Patients who retained their tracheostomies into adulthood were more likely to be older at tracheostomy placement (mean age 14.3 vs. 1.7 years, p < 0.001), Hispanic (43.7% vs. 30.5%, p = 0.003), not ventilated at initial discharge (41% vs. 24%, p < 0.001), and have severe neurocognitive disabilities (72% vs. 53%, p < 0.001). Logistic regression identified older age at tracheostomy placement (OR = 1.35, 95% CI [1.24–1.48]) and severe neurocognitive disability (OR = 6.20, 95% CI [2.13–18.09]) as significant predictors of maintaining a tracheostomy into adulthood.ConclusionsOlder age at tracheostomy placement and severe neurocognitive disabilities significantly predict the transition of pediatric tracheostomy patients to adult care with their tracheostomies. These findings highlight the need for specialized transition programs tailored to the needs of this unique population.Level of Evidence4 Laryngoscope, 135:1186–1191, 2025
Concurrent Image Differentiation and Integration Processings Enabled By Polarization‐Multiplexed Metasurface
Authors: Bi Xinyi , Wu Xuanguang , Fan Xinhao , Zhao Chenyang , Wen Dandan , Liu Sheng , Gan Xuetao , Zhao Jianlin , Li Peng 
Published: October 2024

AbstractOptical computing and image processing performed by sensor front‐end metasurfaces is receiving increasing interest because of advantages such as significant reduction of latency time, energy consumption, and system complexity. Despite the rapid progress, concurrent processing, the most important feature of electronic computing, has not yet been well implemented in optical computing. Here, a metasurface‐based optical image processor that can perform optical differentiation and integration tasks simultaneously is proposed. This optical front‐end processor integrates two coherent transfer functions corresponding to differential and integral convolution kernels into a built‐in metasurface by polarization encoding, allowing concurrent processing of multiple all‐optical computational tasks. The simultaneous differentiation and integration operations on images for edge enhancement and denoising are demonstrated at multiple visible wavelengths. This concurrent processing architecture paves a promising pathway toward multifunctional and higher‐speed image processing for machine vision and biomedical imaging and shows the potential to expedite and potentially supplant certain digital neural network algorithms.