bluuebunny/crossref_metadata_2025_split huggingface dataset:
Folliculin directs the formation of a Rab34–RILP complex to control the nutrient‐dependent dynamic distribution of lysosomes
Authors: Starling Georgina P , Yip Yan Y , Sanger Anneri , Morton Penny E , Eden Emily R , Dodding Mark P 
Published: April 2016

AbstractThe spatial distribution of lysosomes is important for their function and is, in part, controlled by cellular nutrient status. Here, we show that the lysosome associated Birt–Hoge–Dubé (BHD) syndrome renal tumour suppressor folliculin (FLCN) regulates this process. FLCN promotes the peri‐nuclear clustering of lysosomes following serum and amino acid withdrawal and is supported by the predominantly Golgi‐associated small GTPase Rab34. Rab34‐positive peri‐nuclear membranes contact lysosomes and cause a reduction in lysosome motility and knockdown of FLCN inhibits Rab34‐induced peri‐nuclear lysosome clustering. FLCN interacts directly via its C‐terminal DENN domain with the Rab34 effector RILP. Using purified recombinant proteins, we show that the FLCN‐DENN domain does not act as a GEF for Rab34, but rather, loads active Rab34 onto RILP. We propose a model whereby starvation‐induced FLCN association with lysosomes drives the formation of contact sites between lysosomes and Rab34‐positive peri‐nuclear membranes that restrict lysosome motility and thus promote their retention in this region of the cell.
Functional Divergence of the Nuclear ReceptorNR2C1as a Modulator of Pluripotentiality During Hominid Evolution
Authors: Baker Jennifer L , Dunn Katherine A , Mingrone Joseph , Wood Bernard A , Karpinski Beverly A , Sherwood Chet C , Wildman Derek E , Maynard Thomas M , Bielawski Joseph P 
Published: April 2016

AbstractGenes encoding nuclear receptors (NRs) are attractive as candidates for investigating the evolution of gene regulation because they (1) have a direct effect on gene expression and (2) modulate many cellular processes that underlie development. We employed a three-phase investigation linking NR molecular evolution among primates with direct experimental assessment of NR function. Phase 1 was an analysis of NR domain evolution and the results were used to guide the design of phase 2, a codon-model-based survey for alterations of natural selection within the hominids. By using a series of reliability and robustness analyses we selected a single gene, NR2C1, as the best candidate for experimental assessment. We carried out assays to determine whether changes between the ancestral and extant NR2C1s could have impacted stem cell pluripotency (phase 3). We evaluated human, chimpanzee, and ancestral NR2C1 for transcriptional modulation of Oct4 and Nanog (key regulators of pluripotency and cell lineage commitment), promoter activity for Pepck (a proxy for differentiation in numerous cell types), and average size of embryological stem cell colonies (a proxy for the self-renewal capacity of pluripotent cells). Results supported the signal for alteration of natural selection identified in phase 2. We suggest that adaptive evolution of gene regulation has impacted several aspects of pluripotentiality within primates. Our study illustrates that the combination of targeted evolutionary surveys and experimental analysis is an effective strategy for investigating the evolution of gene regulation with respect to developmental phenotypes.
Managing insect collections. Micropezidae (Diptera: Nerioidea) of the Entomological Museum UNAB
Authors: Martínez-Alava Javier O. , Serna Francisco 
Published: April 2016

UNAB consists of several collections that seek to represent the insects of agricultural and forestry significance from the various regions of Colombia, especially the mountainous zone. In order to contribute to knowledge on the Diptera diversity of Colombia found in agricultural ecosystems, the present study looked at the Micropezidae contained in this museum, along with the represented taxa, as well as its current curatorial status and geographic distribution in the country. Currently, the Taxonomic Central Collection houses 107 specimens from the Micropezidae family, which belong to the genera Cardiacephala, Grallipeza, Grallomyia, Mesoconius, Micropeza, Plocoscelus, Paragrallomyia, Poecilotylus, Ptilosphen, Scipopus, and Taeniaptera, representing distribution in 57 municipalities and 12 departments (provinces) of the Colombian Andean region.
Single Charge Electronics with Gold Nanoparticles and Organic Monolayers
Authors: Pluchery O. , Caillard L. , Rynder A. , Rochet F. , Zhang Y. , Salmeron M. , Chabal Y. J. 
Published: April 2016

ABSTRACTGold nanoparticles can be used as ultimate electrical materials for storing electrons or controlling their flow for the next generation nano-electronic devices. These particles are the core element of assemblies where the electrical current is reduced to the smallest possible since electrons are controlled one by one by using the Coulomb blockade phenomenon. We prepared colloidal gold nanoparticles beteween 4 and 15 nm and grafted them on a grafted organic monolayer (GOM) on silicon. GOM are highly ordered monolayers prepared by hydrosilylation of alkene molecules and subsequently modified with an amine group so that gold nanoparticles can be firmly immobilized on top of the layer. We discuss several electrical properties at a single electron level. Using the conductive tip of KPFM, we were also able to reveal the spontaneous charging behavior of the gold nanoparticles so that the local work function of a 10 nm gold nanoparticle is only 3.7 eV. By placing an STM tip above a nanoparticle, Coulomb blockade allows controlling the number of electrons simultaneously injected in the nanoparticle. This opens the way for new kinds of single electron memories or single electron transistors.
Synthesis and characterization of functionalized nano magnetite with phthalocyanines for use in photodynamic therapy
Authors: Balcázar-Pérez M.A. , Ramírez-García G. , Gutiérrez S. , Galindo R. 
Published: April 2016

ABSTRACTMagnetic nanoparticles (MNPs) are a class of materials that can be manipulated under the influence of an external magnetic field. Thanks to the ability of the MNPs to be guided by an external magnetic field that is like "action at a distance", combined with their low cytotoxicity and the intrinsic penetrability of magnetic fields into human tissue, opens up many applications involving the transport and/or immobilization of biological entities [1, 2].This work is focused on the synthesis of magnetite nanoparticles by varied methods, their functionalization with nickel tetrasulfonated phthalocyanine, and the corresponding physicochemical characterization and colloidal stability studies in biologically compatible media. The in vitro production of singlet oxygen by these nanoparticles through photochemical stimulation in ultraviolet and visible region was evaluated, resulting in 4.5 and 4 µM respectly to magnetite synthetized in the group. The increase reactive oxygen species concentration in the cellular environment can result in modification and damage of cellular components, and potentially, cell death and necrosis. Therefore, these materials offer the promise of revolutionary tools for photodynamic therapy and hyperthermia, which are attractive strategies for cancer therapy without systemic toxicity.
Deposition and Photocatalytic Activity of Ag:V2O5 Thin Films
Authors: González-Zavala F. , Escobar-Alarcón L. , Solís-Casados D. A. , Arroyo Rebollar D. , Basurto R. , Haro-Poniatowski E. 
Published: April 2016

ABSTRACTIn this work, the deposition and photocatalytic response of V2O5 thin films modified with different amounts of Ag (Ag:V2O5) is reported. Films were deposited on glass and silicon substrates (100), using the pulsed laser deposition (PLD) technique. A high purity vanadium target, with a different number of silver pellets attached on it were used. Thin films were characterized by energy dispersive spectroscopy (EDS) to determine the elemental chemical composition; structural changes due to the addition of Ag were monitored by Raman spectroscopy; Optical microscopy was used to observe the surface morphology and UV-Vis spectroscopy was employed to determine optical properties. Photocatalytic response of the prepared films was studied through the degradation of a malachite green solution using a solar irradiation source.
Synthesis of Nano/Meso-Structured Silicon Films by Plasma Deposition
Authors: Hernández-Montero William W. , Zúñiga-Islas Carlos , De la Hidalga-Wade Francisco J. , Calleja-Arriaga Wilfrido , Itzmoyotl-Toxqui Adrián 
Published: April 2016

ABSTRACTThe characteristics of silicon films deposited by plasma depend strongly on the reactor parameters. In our experiments, the two-level factorial design was implemented. Pressure, silane and hydrogen flows were set at high and low values for the synthesis of silicon films. Results showed that the flows of silane and hydrogen played a key role, being the influence of pressure low. In particular, the samples at high level of hydrogen exhibited the lowest deposition rate and photosensitivity. On the other hand, the samples at low level of hydrogen showed crystalline regions and high deposition rate. For the lowest dilution ratio, nano/meso-structured silicon films were obtained, showing high photosensitivity and high roughness that increases the scattering of light. These characteristics of our films make them suitable to be used in photovoltaics.
EFEKTIVITAS BIMBINGAN BELAJAR DALAM BIMBINGAN DAN KONSELING DI MADRASAH
Authors: Mustikawan Alfin 
Published: April 2016

This research study was aimed at revealing the effectiveness of the learning guidance services in the guidance and counseling program, particularly: the application, the effectiveness and (4) the problem arising and its causes. This research was a case study. The data were collected through observations, interviews, documentation, and questionnaire. The data were analyzed using the interactive model and the quantitative descriptive technique. <br /> The research findings showed that: (1) the application is effective. As many as 78.78% respondents said that the work of guiding teachers was effective and 68.99% respondents said that subject matter teachers were involved in guiding processes. (2) The results of learning guidance services given academic and nonacademic advantages. As many as 71.52% respondents said that learning guidance services also academic advantages. As many as 86.08% respondents said that learning guidance services also gave non-academic advantages. (3) The problems faced by counselors in applying learning guidance services include the limited time for them to give advice in the classroom and the lack of counselors. These problems are caused by too many class hours for religion lessons and there is no rule for counselors to get into the classrooms. <br /><br />
KUTTAB: MADRASAH PADA MASA AWAL (UMAYYAH) PENDIDIKAN ISLAM
Authors: Fahruddin M. Mukhlis 
Published: April 2016

Kuttab is fist Islamic education institute, the learning is simple system; reading, writing, physical exercise and skill. This institute development potency with Islamic character. The curriculum balanced intellectuality and spirituality. This article gives information about the firs institute education and scientific tradition in Islam. This tradition will hope motivator and innovator to development Islamic education in Indonesia. This article analyses intellectual tradition in Umayyah. The objective of the analyses awakens our awareness of intellectual tradition, because it will lead our nation into a better future. Creating such condition requires the involvement of each component of this nation<br /><br />Key word: Kuttab, Madrasah, Pendidikan Islam, Anak <br /><br />
Pengembangan Kurikulum Pendidikan Agama Islam Muslim Minoritas: Pesantren Nurul Yaqin Papua Barat
Authors: Wekke Ismail Suardi 
Published: April 2016

<span><em>Since the founding of Indonesia as a nation, madrasah already contribute </em><span><em>to education. This history reflcts madrasah to accelerate people need on </em><span><em>education. After long time, madrasah not only stimulate muslim society in </em><span><em>education but also at large fild of life. Therefore, this paper explores how </em><span><em>the process in madrasah to enhance curriculum. In addition, the study will </em><span><em>focus how the administrator of madrasah activate curriculum to extend the</em><br /><span><em>environment in minority muslim. This study was conducted in qualitative </em><span><em>approach. To step up the process of analysis, case study was implemented. </em><span><em>During data collection, in-depth interview and non-participant observation </em><span><em>were employed. Interview guidelines and observation sheet were carried </em><span><em>out to direct the study. Research fidings shows that madrasah in minority </em><span><em>muslim, in this study is Pesantren Nurul Yaqin, formulates some programs </em><span><em>and activities to develop the madrasah curriculum. Some programs were</em><br /><span><em>practiced to accumulate information from parents, practitioner, and decision </em><span><em>maker. There are several processes to enlarge participation and invite </em><span><em>people to contribute to the learning material in curriculum. The institution </em><span><em>on multiethnic and multicultural society has challenge to synchronize </em><span><em>aspiration form different side. On this opportunity to contribute, madrasah </em><span><em>accelerate its curriculum in expanding this environment condition. Finally, </em><span><em>this research conclude that madrasah in minority muslim on curriculum </em><span><em>advancement has chance to encourage students competency that differ </em><span><em>from other majority muslim.</em><br /><span><strong>Keywords: </strong><span><em>curriculum, enhancement, minority, society</em></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><br /><br class="Apple-interchange-newline" /></span></span>
Pembelajaran Sejarah Peradaban Islam Melalui Online Game And Quiz
Authors: Abubakar Isti'anah 
Published: April 2016

History of Islamic civilization is a subject which gives advantages for all people who learn it, but unfortunately it can’t be realized in the results of learning. The impression of monotonous, static, bored, and saturated is responses that always appears when people learning history. Online gameand quiz is application that helped by web and internet access which enable students and teachers to learn History of Islamic civilization easily. This application indirectly make easy students and teachers to minimize the main problems in learning History of Islamic Civilization, they are complexity of material and students’ overfullness. As one alternative in learning History of Islamic civilization, this application still needs improvement. Sharing between teachers of History of Islamic civilization is defiitely expected to make this application better.Keywords : Online game and Quiz and learning of History
Pengembangan Buku Ajar Tematik Dengan Pendekatan Integrasi Sains Dan Agama Di Kelas 4 Sekolah Dasar Islam Raudlatul Jannah Sidoarjo
Authors: Nuzulia Nuril 
Published: April 2016

<span><em>Purpose of this development is to fulfil the needs of learning material </em><span><em>especially in the Islamic Elementary School. In fact, thematic learning </em><span><em>separated from religion; therefore continuity of learning model that will be </em><span><em>applied is needed. This day, general subject different with religion subject,</em><br /><span><em>therefore in this research, researcher integrated between general subjects </em><span><em>with religion subject. This development of teaching material is using Dick </em><span><em>and Lou Carey model. The result of this development is Thematic Book for </em><span><em>student 4</em><span><em>th </em><span><em>grade of Islamic Elementary School. Product of this development </em><span><em>is tested in a series such as: (1) validation of contents, learning design, and </em><span><em>learning, (2) Tested on small group and tested on class.</em><br /><span><strong>Keywords: </strong><span><em>Development, Teaching Material, Thematic, Integration</em><br /><span><em>between Sciences and Religion</em></span></span></span></span></span></span></span></span></span></span></span><br /><br class="Apple-interchange-newline" /></span></span></span></span>
Menggagas Pendidikan Berbasis Nilai-Nilai Civil Society di Madrasah
Authors: .. Baharuddin 
Published: April 2016

In an effort to realize the civil society (civil society) need for serious efforts to build and develop civic cultur (cultural refiement). Compressive point, the social aspect and the social networks that are considered a weak point for the creation of a strong horizontal social entities. With an emphasis on that aspect, is expected madrasa can lead to cooperation among citizens in resolving public issues around it. The existence of social change in valuesbased education civil society produces promising practices, but not a fewsocial changes it gave birth to the contrary, become more childbirth social practices that “do not educate”. Where the importance we look back at how the process of social change in education based on the values of civil society could bring about a change in the desired direction.Keyword: Madrasah, Civil Society, learning Society
Pengembangan Buku Ajar Tematik Integratif Semua Mata Pelajaran Di Sekolah Dasar Islam
Authors: .. Sulistyowati 
Published: April 2016

Development of the fist class textbook using a thematic approach to integrative learning in Islamic primary school (SDI) based on the fact that the unavailability of special thematic textbook for students who attend school in Islamic institutions that accommodate all subjects including PAIand manners. The approach chosen thematic learning because students in the early grades still think holistically. They see something to make a whole, so that the thematic approach is the right approach to use.In this textbookdevelopment, developers use development methods in general, the planning, development, validation, testing, and dissemination. Development design model used is a model of Dick and Lou Carey. The results showed that the textbook class I by using thematic integrative learning approach has a level of effectiveness, effiiency, and attractiveness high. This is indicated by the test results are in good category according to a scale of 5 and an increase in student scores of 7.38. Thus, it can be said the development has contributedto the settlement of problems that arise in schools, especially on thematic integrative learning all subjects, including religion in class I. The product of this development can be disseminated to students who have the same characteristics.Keywords: Development, Textbook, Thematic Integrative Learning
Keberadaan Badan Akreditasi Provinsi Sekolah/Madrasah (Upaya Meningkatkan Mutu Pendidikan Madrasah Di Provinsi Jambi)
Authors: Jailani M. Syahran 
Published: April 2016

This research is intended to look into the existence of Province Acreditation for School and Islamic School in Jambi through the policies and programs executed, include the result of acreditation for islamic school at Ministry of Religious Affairs in Jambi. The data from Jambi Ministry of Religious Affairs in 2012 showed that from 538 islamic schools which have been acreditated, ie:(a) 244 Islamic Kindergarten, 169 (7,63%) kindergartens were acreditated, 75 (28,37%) kindergartens were not acreditated, (b). 263 Islamic Elementary School, 171 (61%) schools were acreditated, 98 (38,20%) schools were not acreditated, (c) 345 Islamic Junior High School, 158 (44,99 %) schools were acreditated, 187 (55,01%) schools were not acreditated and (d) 184 Islamic Senior High School, 88 (47,01%) schoolswere acreditated and 96 (52,99%) schools were not acreditated. From 1036 educational institutions, there have been 450 (43,44%) islamic schools which were acreditated while there were 586 (56,56%) isclamic schools which were not acreditated. The main problem which happenned was there were many islamic schools got C in acreditation and even some schools were not acreditated. It was caused by: (a) socialization, (b) limitted fund, (c) geographical condition, (d) the low network among islamic schools and (e) there were many policies which have not been accompanied by commitment fully.Keywords : Madrasah/School Acreditation Board, The Quality Of Madrasah Education.
Analisis Pemahaman Konsep Sains Guru Kelas Madrasah Ibtidaiyah
Authors: Wibowo Agus Mukti 
Published: April 2016

Most of the concepts in science are abstract ones. These concepts tend to be diffiult to study by students who have not developed formal thinking ability. This diffiulty may cause misconception, i.e. students’ conceptions which are different from those generally accepted by the scientificommunity. Understanding of teacher in non PGMI / PGSD on material science at Islamic Elementary School is still considered to be lacking or need improvement. Misconception that occurs teacher non PGMI / PGSD to learning materials science at Islamic Elementary School almost occurredin all of the material, among other things, the material of plant, animal material changes (water and solvent) light and the solar systemKeywords: material science, scientifi, misconception
Diseño y generación de transmisiones de potencia por correa trapecial en Solidworks mediante una aplicación en Visual Basic
Authors: Ozaeta Eidelman Aeljandro , Flórez García Luis Carlos , Higuera Cobos Oscar Fabián 
Published: April 2016

<p>Se presenta el procedimiento de diseño de transmisiones de potencia por correa trapecial según la norma BS 3790, mediante una aplicación desarrollada en Microsoft Visual Studio 2008 y utilizando el lenguaje de programación Visual Basic. El programa utiliza los parámetros de operación de la transmisión ingresada por el usuario, y mediante los cálculos estandarizados y una base de datos conformada por diversos catálogos de poleas y correas, muestra todas las transmisiones que satisfacen los requerimientos ingresados; además, permite la generación del modelo sólido de cada transmisión en SolidWorks.</p>
Análisis de soldabilidad de aceros inoxidables con aceros de medio y bajo carbono por SMAW
Authors: Marulanda Arevalo José Luddey , Burbano Victor Manuel , Peláez Jaime Andrés 
Published: April 2016

<p>Se presenta un estudio de la soldabilidad de aceros inoxidables austeníticos AISI 304 y AISI 316 con aceros de bajo y medio carbono AISI 1020 – AISI 1045, empleando como materiales de aporte los electrodos EutecTrode® 52 NG, 54 NG y 57 NG, mediante el proceso de arco eléctrico con electrodo revestido (SMAW). Para analizar la soldabilidad de estos electrodos cuando se realiza la unión de aceros inoxidables con aceros al carbono, se practicaron pruebas metalográficas y ensayos mecánicos de dureza, doblez y tracción, con el fin de observar el comportamiento tanto de la zona afectada térmicamente como del cordón de soldadura, a partir del cambio en las propiedades mecánicas y metalúrgicas en las diferentes regiones de las uniones soldadas. Durante el proceso de soldadura se siguió una especificación del procedimiento de soldadura (WPS), para que los resultados fueran repetibles, minimizando los problemas de agrietamiento en caliente, agrietamiento en frío, formación de fase sigma y precipitación de carburos.</p>
Aplicación del estándar ISO/IEC 9126-3 en el modelo de datos conceptual entidad-relación
Authors: González Pinzón Miguel Fernando , González Sanabria Juan Sebastián 
Published: April 2016

<p>Presenta una reflexión sobre las consideraciones y recomendaciones que se deben tener en cuenta para evaluar los criterios de calidad del Modelo<br />Conceptual, dentro del ciclo de vida de las bases de datos, presentando una revisión de la temática, en la que se tienen en cuenta diversos factores dados por autores destacados en el área, y por estándares como la ISO/IEC 25012, la ISO/IEC 9126-3 y la ISO/IEC 25024.</p>