bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti‐Inflammatory and Osteoprotective Effects of Cannabinoid‐2 Receptor Agonist HU‐308 in a Rat Model of Lipopolysaccharide‐Induced Periodontitis
Authors: Ossola Cesar A. , Surkin Pablo N. , Mohn Claudia E. , Elverdin Juan C. , Fernández‐Solari Javier 
Published: February 2016

Background: Anti‐inflammatory and immunologic properties of cannabinoids have been reported in several tissues. Expression of cannabinoid receptor Type 2 was reported in osteoblasts and osteoclasts, suggesting a key role in bone metabolism. The aim of this study is to assess the effect of treatment with cannabinoid‐2 receptor agonist HU‐308 in the oral health of rats subjected to lipopolysaccharide (LPS)‐induced periodontitis.Methods: Twenty‐four rats were distributed in four groups (six rats per group): 1) control rats; 2) sham rats; 3) rats submitted to experimental periodontitis (LPS); and 4) rats submitted to experimental periodontitis and treated with HU‐308 (LPS+HU). In groups LPS and LPS+HU, periodontitis was induced by LPS (1 mg/mL) injected into the gingival tissue (GT) of maxillary and mandibular first molars and into the interdental space between the first and second molars, 3 days per week for 6 weeks. In group LPS+HU, HU‐308 (500 ng/mL) was applied topically to the GT daily.Results: Alveolar bone loss resulting from LPS‐induced periodontitis was significantly attenuated with HU‐308 treatment (LPS+HU), measured by macroscopic and histologic examination. Treatment also reduced gingival production of inflammatory mediators augmented in LPS‐injected rats, such as: 1) inducible nitric oxide (iNOS) activity (LPS: 90.18 ± 36.51 pmol/minute/mg protein versus LPS+HU: 16.37 ± 4.73 pmol/minute/mg protein; P <0.05); 2) tumor necrosis factor alpha (LPS: 185.70 ± 25.63 pg/mg protein versus LPS+HU: 95.89 ± 17.47 pg/mg protein; P <0.05); and 3) prostaglandin E2 (PGE2) (LPS: 159.20 ± 38.70 pg/mg wet weight versus LPS+HU: 71.25 ± 17.75 pg/mg wet weight; P <0.05). Additionally, HU‐308 treatment prevented the inhibitory effect of LPS‐induced periodontitis on the salivary secretory response to pilocarpine. Moreover, iNOS activity and PGE2 content, which were increased by LPS‐induced periodontitis in the submandibular gland, returned to control values after HU‐308 treatment.Conclusion: This study demonstrates anti‐inflammatory, osteoprotective, and prohomeostatic effects of HU‐308 in oral tissues of rats with LPS‐induced periodontitis.
Revealing contrasting genetic variation and study of genetic diversity in urdbean (Vigna mungo (L.) Hepper) using SDS-PAGE of seed storage proteins
Authors: Tripathy Swapan Kumar , Mohanty Priyadarshini , Jena Monalisha , Dash Gokul Bihari , Pradhan Kedareswar , Nayak Pramod Kumar , Dash Sasmita , Lenka Devraj , Mishra Dayanidhi , Mohapatra Pavitra Mohan , Swain Digbijaya , Senapati Niranjan 
Published: February 2016

<p><strong>Total seed storage protein profiles of 20 urdbean genotypes including the popular variety T9 were analysed by Sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). 14 genotypes could be clearly identified based on genotype-specific seed protein fingerprints while rest of the test genotypes were categorized into three protein types. Dendrogram based on electrophoretic data clustered the genotypes into seven groups at 78.5% phenon level. TU 95-1 with TU 12-25-4 revealed lowest similarity index value (0.33) followed by TU 95-1 with PU 30 and KU 96-3(SI=0.35). Clustering pattern revealed distinctly divergent group formed by TPU 95-1 and TPU 4. These may serve as a valuable source genotype in recombination breeding. </strong></p><p><strong>Key words: </strong>Seed storage protein profiling, SDS-PAGE, Genetic variation, urdbean.<strong></strong></p>
RECONCILE THE RELIGION AND SCIENCE EDUCATION MANAGEMENT IN ISLAM
Authors: Kurniawan Syamsul 
Published: February 2016

<p class="Normal1"><span class="normalchar"><em><span lang="EN-US">This research is aimed to reconcile science and religion, and to seek its relevance in the management of non-dichotomous Islamic education.</span></em></span><span class="normalchar"><em><span lang="EN-US">In addition, this research departs from the researcher’s anxiety in response to the dichotomous thought between religion and science which in turn manifests in the separation of science and religion in the history of Islamic education management.</span></em></span><span class="apple-converted-space"><span lang="EN-US"> </span></span><span class="normalchar"><em><span lang="EN-US">This results in the current Islamic education that suffers a setback in the development of science.</span></em></span><span class="apple-converted-space"><span lang="EN-US"> </span></span><span class="normalchar"><em><span lang="EN-US">Therefore, in the management of Islamic education, reintegration needs to be done without any dichotomy between religion and science.</span></em></span></p>
THE UNITY GAIT OF TARBIYAH ISLAMIYAH IN ISLAMIC EDUCATION IN MINANGKABAU
Authors: Maimunah Maimunah 
Published: February 2016

<p class="no0020spacing"><em>In the early 20th century, Islamic scholars in Minangkabau are divided into two groups: the old and young groups.</em><em> </em><em>The old group is those in the field of faith committed themselves to the Ahlus Sunnah wal Jama'ah from </em><em>Abu Hasan al-Asy’ari and Abu Muslim al-Maturidi. In the areas of worship, they are attached to Syafi’i. Although not all of them embrace the teachings of the congregation, in principle they admit the truth of mu’tabarah as defense from the young group. There are two main issues in that decision. The first is periama, the preservation issues of Sunniyah Syafi’iyah. The second is Minangkabau traditional preservation issues. These problems are summed up in one of the PERTI objectives, the results of the Bukititnggi congress which reinforce and strengthen adat</em> nan kawi, syara' nan lazim<em> </em><em>in each country.</em><em> </em><em>The old group in Minangkabau strongly holds </em><em>Syafi’i to be the foundation of every move in their struggle to both social and civic education.</em></p>
Intento suicida y antecedente de experiencias traumáticas durante la infancia en adultos con diagnóstico de depresión, trastorno de personalidad limítrofe o esquizofrenia.
Authors: Cáceres-Taco Elisa , Vásquez-Gómez Freddy 
Published: February 2016

La historia de experiencias traumáticas en la infancia ha sido asociada con el desarrollo de psicopatología en lapoblación adulta, no solamente con el incremento de riesgo para trastornos psiquiátricos, sino también con laocurrencia de posteriores intentos suicidas y peor pronóstico en el curso de la enfermedad. Objetivos: Determinar larelación entre el antecedente de trauma infantil y el posterior intento suicida en pacientes adultos con diagnóstico dedepresión, trastorno de personalidad limítrofe o esquizofrenia. Material y métodos: Se realizó un estudio descriptivocorrelacional aplicando un muestreo secuencial. Los autores recogieron los datos de los pacientes del consultorioexterno de adultos del Instituto Nacional de Salud Mental “Honorio Delgado- Hideyo Noguchi” durante los mesesde febrero y marzo del año 2013. A dichos sujetos se les aplicó la ficha de recolección de datos y la Escala deTrauma de Marshall, que evalúa la historia de eventos traumáticos. Resultados: Se entrevistaron 200 pacientes, el76% de ellos de sexo femenino. Los pacientes con personalidad limítrofe presentaron mayor proporción de intentos suicidas (83,1%), seguidos de aquellos con diagnóstico de depresión (43,1%) y esquizofrenia (20,6%). Se observó una elevada prevalencia de politrauma (más de tres eventos traumáticos) en todos los pacientes, encabezados por aquellos con personalidad limítrofe. Conclusiones: Existe una mayor frecuencia de trauma infantil en pacientes con trastorno de personalidad limítrofe en comparación con depresión y esquizofrenia; además existe el doble de probabilidad de cometer intento suicida entre aquellos pacientes que presentaron tres o más eventos traumáticos respecto a aquellos sin dicho antecedente.
Frecuencia del síndrome de Burnout y niveles de sus dimensiones en el personal de salud del servicio de emergencia de pediatría del Hospital Nacional Cayetano Heredia en el año 2014. Lima, Perú.
Authors: Vásquez-Manrique Jim F. , Maruy-Saito Aldo , Verne-Martin Eduardo 
Published: February 2016

El personal de salud que atiende población pediátrica está en continuo riesgo de presentar Síndrome de Burnout (SBO). Objetivos: Determinar la frecuencia del SBO y los niveles de sus dimensiones en los trabajadores del Servicio de Emergencia Pediátrica del Hospital Nacional Cayetano Heredia. Materiales y métodos: Se realizó un estudio descriptivo, transversal, en todos los trabajadores del Servicio de Emergencia de Pediatría del Hospital Nacional Cayetano Heredia durante los meses de febrero y marzo del año 2014. Se utilizó el instrumento Maslach Burnout Inventory-HS traducido y validado al español. Resultados: Participaron 54 trabajadores entre médicos (25), enfermeras (16) y técnicos de enfermería (13). La frecuencia de SBO fue de 3,76% (n = 2), el 12,97% (n = 7) de los participantes presentó un nivel alto de cansancio emocional, el 11,12% (n = 6) presentó un nivel alto de despersonalización, y el 14,81% (n = 8) presentó un bajo nivel de realización personal. Conclusiones: La falta de trabajo de la cónyuge, sexo, condición laboral y tiempo de trabajo tuvieron relación estadísticamente significativa con las dimensiones de este síndrome.
Crisis epilépticas en la demencia de la enfermedad de Alzheimer
Authors: Castro-Suarez Sheila , Guevara-Silva Erik , Lira David , Mar Marcela , Herrera-Pérez Eder , Núñez del Prado Liza , Montesinos Rosa , Custodio Nilton 
Published: February 2016

La enfermedad de Alzheimer y la epilepsia no solo comparten la edad avanzada como un factor de riesgo, si no también compartirían mecanismos subyacentes en su etiología. Las crisis epilépticas generalmente fueron reportadas en estadios tardíos de la enfermedad de Alzheimer; sin embargo los pacientes con enfermedad de Alzheimer familiar con mutaciones en la PSEN1, PSEN2 y proteína precursora del amiloide tienen mayor riesgo de desarrollar crisis epilépticas aún en estadios tempranos de la enfermedad. Por otro lado la epilepsia del lóbulo temporal podría generar per sé compromiso de memoria y la esclerosis hipocampal generar reorganización de redes neuronales excitatorias e inhibitorias que daría como resultado una actividad epiléptica. Es importante reconocer e iniciar tratamiento temprano en pacientes con Enfermedad de Alzheimer y epilepsia para evitar mayor deterioro cognitivo y mejorar la calidad de vida de estos pacientes
Alzheimer’s disease: Toward the rational design of an effective vaccine.
Authors: Marciani Dante J. 
Published: February 2016

The promising clinical results with the human monoclonal antibodies aducanumab and solanezumab targeting β-amyloidin Alzheimer’s disease treatment, confirm both the amyloid cascade hypothesis and protective natural immunity, while strengthening the immunotherapeutic approach. That aducanumab recognizes a conformational epitope formed by oligomers emphasizes the need for whole β-amyloid, not just its B-cell epitopes as have been the norm to avoid pro-inflammatory Th1-reactions. That truncated β-amyloid having N-terminal pyroglutamate is present only in diseased brain simplies a new useful vaccine antigen. Another relevant antigen is the tau protein, which shows a close association and cooperativity with β-amyloid in exacerbating this disease. Hence, effective vaccines may be polyvalent, presenting to the immune system a number of antigens relevant to induce an immune response to prevent or slowdown the onset of this disease. The presence of both B and T cell epitopes in the antigens, require a sole Th2 immunity to avert brain inflammation; a task that cannot be attain with adjuvants that under any conditions induce Th1and/or Th17immunities.Hence, new vaccine adjuvants are need to safely induce Th2 while inhibiting Th1 immunity, an objective that can be achieved with certain fucosylated glycans or triterpene glycosides, which apparently bind to the DC-SIGN lectin on dendritic cells polarizing the immune response toward Th2 immunity. Because the triterpene glycosides have the pharmacophore needed to co-stimulate T cells, they may ameliorate the T-cell anergy associated with immunosenescence and responsible for poor vaccine efficacy in theelderly population, a critical issue for an Alzheimer’s vaccine.
Enfermedad de Moyamoya: reporte de un caso.
Authors: Ramírez-Quiñones Jorge A. , Barrientos-Imán Danny M. , Calle-La Rosa Pilar , Ecos-Quispe Rosa L. , Novoa-Mosquera María E. , Valencia-Chávez Ana M. , Abanto-Argomedo Carlos 
Published: February 2016

La enfermedad de Moyamoya es una patología caracterizada por la estenosis progresiva de la arteria carótida interna y sus ramas principales. Es de etiología desconocida, tiene como forma de presentación a la enfermedad cerebrovascular isquémica o hemorrágica, siendo la primera más frecuente, y afecta en mayor proporción a niños y adultos jóvenes constituyendo un reto diagnóstico. Su presencia se confirma mediante la angiografía por sustracción digital (ASD) y el manejo es médico y/o quirúrgico, siendo el último el que se asocia a un mejor pronóstico. Comunicamos el caso de un paciente peruano de ascendencia japonesa, sin factores de riesgo, con una hemorragia intracraneal cuyo diagnóstico final fue enfermedad de Moyamoya.
Estructura de la sintomatología depresiva en una muestra de mujeres con menos de un año postparto.
Authors: Vega-Dienstmaier Johann M. 
Published: February 2016

Objetivos: Explorar la estructura de la sintomatología depresiva en mujeres postparto. Material y Métodos: En 321 mujeres que acudieron a un hospital general con menos de 1 año postparto, se exploró, mediante correlaciones tetracóricas y regresiones logísticas, la vinculación entre diversos síntomas depresivos, y entre éstos y el diagnóstico de depresión mayor. Resultados: Los síntomas que tuvieron mayor vinculación entre sí y también con el diagnósticode depresión mayor fueron: fatiga, tristeza, anhedonia, tendencias suicidas, hiporexia, dificultades de concentración, retardo psicomotor, sentimientos de culpa, agitación psicomotriz y pesadez de extremidades. Por otro lado, la hipersomnia y el apetito elevado no se relacionaron con el resto de sintomatología depresiva. Conclusiones: Los resultados del estudio sugieren que, en esta muestra de mujeres postparto, la hipersomnia y la elevación del apetito no forman parte del síndrome depresivo; y que los síntomas centrales de la depresión son: fatiga, tristeza y anhedonia, los cuales coinciden con los tres síntomas que la CIE-10 considera fundamentales para el diagnóstico de depresión.
The Natural Resources Conservation Service Land Resource Hierarchy and Ecological Sites
Authors: Salley Shawn W. , Talbot Curtis J , Brown Joel R. 
Published: February 2016

Core Ideas
Propose the creation of Land Resource Areas through landscape ecology principles of subdivision.
Integrate nested hierarchical relationships into the NRCS Land Resource Hierarchy.
Place Ecological Sites as a nested resource area scale in the NRCS Land Resource Hierarchy.
Resource areas of the Natural Resources Conservation Service (NRCS) have long been important to soil geography. At both regional and landscape scales, resource areas are used to stratify programs and practices based on geographical areas where resource concerns, problems, or treatment needs are similar. However, the inability to quantifiably delineate and classify resource area boundaries hinders communication across the NRCS and federal agencies. Without strong standards delineating geography and concepts, resource areas become less scientifically defensible and inconsistent in addressing similar resource management issues. Furthermore, with continued development of ecological site (ES) concepts, there is a renewed interest in understanding the relationships between resource areas and ESs. In this paper we: (i) review the concepts and history of landscape classifications leading to the predominant regional classification systems used by federal agencies in the USA, (ii) propose strengthening the NRCS's Land Resource Hierarchy (LRH) by building resource area concepts on nesting principles of subdivision instead of aggregation, and (iii) place ecological site concepts as a nested resource area within the LRH.
A Measurement Method for Rill and Ephemeral Gully Erosion Assessments
Authors: Wells Robert R. , Momm Henrique G. , Bennett Sean J. , Gesch Karl R. , Dabney Seth M. , Cruse Richard , Wilson Glenn V. 
Published: February 2016

Core Ideas
Photogrammetric techniques for spatiotemporal measure of topographic data
Physical data for validation and development of soil erosion modeling technology
Automated analysis presentation package
Rill and ephemeral gully monitoring at high spatial and temporal resolution
When flowing water concentrates on hillslopes, the erosivity of the water may only be limited by the erodibility of the soil. Over time, concentrated flow paths may become permanent drainage channels, and such rills and ephemeral gullies often have negative impacts on crop yield and downstream sedimentation. Spatiotemporal topographic assessments of rill and gully dimensions compliment hydraulic erosion estimates, and they can elucidate soil erosion processes and provide data for model validation. Accurate and detailed topographic assessments, however, can be cost prohibitive. The objectives of this study are to describe and evaluate a topographic assessment method with relatively high spatial and temporal resolution, to discuss its costs and limitations, and to provide an assessment procedure for erosion characterization and data optimization. Three locations are evaluated that are pertinent to soil erosion research on the field, plot, and laboratory scale. In each setting, the sites are monumented and monitored using photogrammetric techniques. Photogrammetry is a simple, robust means to track landscape evolution and morphodynamic changes in rills and ephemeral gullies. The assessment procedure describes study site attributes at a variety of spatial and temporal scales, it is cost‐effective, workforce empowering, and reliable, and the analysis and presentation can be automated. Capturing this type of information is critical to an improved understanding of the fundamental principles necessary to enhance modeling technology to estimate erosion potential at various scales and to assess the efficacy of conservation practices.
The Crisis Intervention Team (CIT) Model for Law Enforcement: Creative Considerations for Enhancing University Campus Police Response to Mental Health Crisis
Authors: Segal Emily 
Published: February 2016

Abstract

Purpose of the article American university and college campus law enforcement, like their peers in American munipal law enforcement agencies, find themselves interacting frequently with civilians experiencing mental health disturbances. An innovative model for law enforcement, the Crisis Intervention Team (CIT) model, has been developed to address the difficulties law enforcement professionals and civilians in mental health crisis face during encounters. (Margolis & Shtull, 2012) This article explores how CIT can enhance police response to mental health crisis on the college campus.

Methodology/methods Methods of applied research were conducted, borrowing from a benchmarking model and including interviews with multiple key informants representing law enforcement and mental health. Informants were affiliated with three universities and multiple municipal jurisdictions in Virginia, USA.

Scientific goal The goal was to assess the relevance of CIT on the college campus and explore creative approaches to enhancing campus police response to mental health crisis.

Findings The results supported the scholarly literature regarding the efficacy of the CIT model. Creative adaptations to the CIT model for campus possibly can be implemented to address concerns of mental health crisis on campus.

Conclusions CIT is a highly innovative model requiring extensive collaboration between law enforcement, mental health agencies, and mental health advocates. As standard qualitative research was not conducted, the sample size of key informants may not have reached saturation. However, findings from the interviews support the body of literature on CIT. The implementation of CIT on the college campus could possibly help to alleviate difficulties on campus arising from mental health crisis, including reducing inappropriate arrest or disciplinary action, improving campus safety, addressing concerns related to threat assessment and management, and enhancing collaborative efforts on campus and with resources in the broader community.
Cityness and Informativeness of the Emerging Informational Cities in Japan
Authors: Fietkiewicz Kaja J. , Stock Wolfgang G. 
Published: February 2016

Abstract
Based on the concept of Informational Cities, which are the highly developed prototypical cities of the 21st century, we conducted a regional comparison of four Japanese cities in terms of their “cityness” and “informativeness”. The purpose of our articles is to specify the theoretical framework for measuring the informativeness and cityness level of any desired city, to quantify the chosen indicators in order to compare the investigated cities, and finally, to conclude what is their advancement level in terms of a modern city of the knowledge society. Our methodology is based on a new approach to measure the position of a city in a national or a global scale, originating from information science and its indicators of the knowledge society. It includes such procedures as desktop research and bibliometrics, ethnographic field study, or grounded theory method. The investigated aspects under the notion of the informativeness level are the distinct labour market and mix of companies located in the city (concerned with creative, knowledge and information economy), as well as the progressive e-governance and advanced e-government. The notion of cityness level oscillates around the concept of space of flows in the city, including the flow of money, power, information, and human capital. In order to make our model practical and grounded on available evidence, we have chosen four Japanese cities to undergo the process. Tokyo, Yokohama, Osaka and Kyoto are big and economically significant Japanese metropolises. However, our results show that they differ from each other regarding many important aspects. We were able to quantify their performances and create a ranking. The limitation of our approach appears to be the strict quantification method that makes the cityness and informativeness levels of the cities dependent on other cities’ performances, and that does not precisely reflect the actual dimension of the differences between them. Hence, in the future work we will develop a more flexible and independent approach, enabling us to make more accurate statements on cities’ advancement unregarded the advancement level of the other metropolises.