bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between advanced cancer patients' survival and family caregiver presence and burden
Authors: Dionne‐Odom J. Nicholas , Hull Jay G. , Martin Michelle Y. , Lyons Kathleen Doyle , Prescott Anna T. , Tosteson Tor , Li Zhongze , Akyar Imatullah , Raju Dheeraj , Bakitas Marie A. 
Published: February 2016

AbstractWe conducted a randomized controlled trial (RCT) of an early palliative care intervention (ENABLE: Educate, Nurture, Advise, Before Life Ends) for persons with advanced cancer and their family caregivers. Not all patient participants had a caregiver coparticipant; hence, we explored whether there were relationships between patient survival, having an enrolled caregiver, and caregiver outcomes prior to death. One hundred and twenty‐three patient‐caregiver dyads and 84 patients without a caregiver coparticipant participated in the ENABLE early versus delayed (12 weeks later) RCT. We collected caregiver quality‐of‐life (QOL), depression, and burden (objective, stress, and demand) measures every 6 weeks for 24 weeks and every 3 months thereafter until the patient's death or study completion. We conducted survival analyses using log‐rank and Cox proportional hazards models. Patients with a caregiver coparticipant had significantly shorter survival (Wald = 4.31, HR = 1.52, CI: 1.02–2.25, P = 0.04). After including caregiver status, marital status (married/unmarried), their interaction, and relevant covariates, caregiver status (Wald = 6.25, HR = 2.62, CI: 1.23–5.59, P = 0.01), being married (Wald = 8.79, HR = 2.92, CI: 1.44–5.91, P = 0.003), and their interaction (Wald = 5.18, HR = 0.35, CI: 0.14–0.87, P = 0.02) were significant predictors of lower patient survival. Lower survival in patients with a caregiver was significantly related to higher caregiver demand burden (Wald = 4.87, CI: 1.01–1.20, P = 0.03) but not caregiver QOL, depression, and objective and stress burden. Advanced cancer patients with caregivers enrolled in a clinical trial had lower survival than patients without caregivers; however, this mortality risk was mostly attributable to higher survival by unmarried patients without caregivers. Higher caregiver demand burden was also associated with decreased patient survival.
Radiation‐induced mesothelioma among long‐term solid cancer survivors: a longitudinal analysis of SEER database
Authors: Farioli Andrea , Ottone Marta , Morganti Alessio G. , Compagnone Gaetano , Romani Fabrizio , Cammelli Silvia , Mattioli Stefano , Violante Francesco S. 
Published: February 2016

AbstractWe investigated the association between external beam radiotherapy (EBRT) and pleural and peritoneal mesothelioma among long‐term (>5 years) solid cancer survivors. We analyzed data from the US Surveillance, Epidemiology, and End Results (SEER) program (1973–2012). We fitted survival models adjusted by age, gender, race, year, surgery, and relative risk of primary mesothelioma in the county of residence (proxy for individual asbestos exposure). We estimated hazard ratios [HR] with reference to nonirradiated patients. We distinguished between scattered and direct irradiation to study the dose–response. We observed 301 mesotheliomas (265 pleural; 32 peritoneal; 4 others) among 935,637 patients. EBRT increased the risk of mesothelioma (any site; HR 1.34, 95% CI 1.04–1.77). We observed an increased risk of pleural mesothelioma (HR for EBRT 1.34, 95% CI 1.01–1.77), but we did not find signs of a dose–response relationship (HR for scattered irradiation 1.38; HR for direct irradiation 1.23). On the opposite, only direct peritoneal irradiation was associated with peritoneal mesothelioma (HR 2.20, 95% CI 0.99–4.88), particularly for latencies ≥10 years (HR 3.28, 95% CI 1.14–9.43). A competing risks analysis revealed that the clinical impact of radiation‐induced mesothelioma was limited by the high frequency of competing events. The cumulative incidence function of mesothelioma after 40 years of observation was very low (nonirradiated patients 0.00032, irradiated patients 0.00055).EBRT might be a determinant of mesothelioma. Longer latency periods are associated with higher risks, while the dose–response seems nonlinear. The clinical impact of mesothelioma after EBRT for primary solid cancers is limited.
The AhR is involved in the regulation of LoVo cell proliferation through cell cycle‐associated proteins
Authors: Yin Jiuheng , Sheng Baifa , Han Bin , Pu Aimin , Yang Kunqiu , Li Ping , Wang Qimeng , Xiao Weidong , Yang Hua 
Published: February 2016

AbstractSome ingredients in foods can activate the aryl hydrocarbon receptor (AhR) and arrest cell proliferation. In this study, we hypothesized that 6‐formylindolo [3, 2‐b] carbazole (FICZ) arrests the cell cycle in LoVo cells (a colon cancer line) through the AhR. The AhR agonist FICZ and the AhR antagonist CH223191 were used to treat LoVo cells. Real‐time PCR and Western blot analyses were performed to detect the expression of the AhR, CYP1A1, CDK4, cyclinD1, cyclin E, CDK2, P27, and pRb. The distribution and activation of the AhR were detected with immunofluorescence. A 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide (MTT) assay and flow cytometric analysis were performed to measure cell viability, cell cycle stage, and apoptosis. Our results show that FICZ inhibited LoVo cell proliferation by inducing G1 cell cycle arrest but had no effect on epithelial apoptosis. Further analysis found that FICZ downregulated cyclinD1 and upregulated p27 expression to arrest Rb phosphorylation. The downregulation of cyclinD1 and upregulation of p27 were abolished by co‐treatment with CH223191. We conclude that the AhR, when activated by FICZ (an endogenous AhR ligand), can arrest the cell cycle and block LoVo cell proliferation.
Correlates and outcomes related to periprocedural myocardial injury during percutaneous coronary intervention for chronic total occlusion: Results from a prospective, single center PCI registry
Authors: Zhang Qi , Hu Jian , Yang Zhen Kun , Ding Feng Hua , Zhang Jian Sheng , Du Run , Zhu Tian Qi , Shen Wei Feng , Kirtane Ajay J. , Zhang Rui Yan 
Published: February 2016

BackgroundThere is increasing interest in percutaneous coronary intervention (PCI) for chronic total occlusions (CTO). Periprocedural myocardial injury (PMI) post CTO PCI is not uncommon, but true incidence and implications of PMI are not well understood.ObjectivesThis study aimed to investigate risk factors for PMI post CTO PCI and its implications for the 1‐year clinical outcome of a Chinese population.MethodsBaseline characteristics, procedure features, and major adverse cardiac events (MACE) at 1 year were assessed in 629 consecutive patients who underwent CTO PCI. PMI was diagnosed as an elevation of creatine kinase MB ≥3 times ULN 12–24 hr post procedure. Multivariate analysis was performed to determine the correlates of PMI and MACE at 1‐year follow‐up.ResultsIn total, PMI was detected in 115 patients (18.3%). Compared with patients without PMI, those with PMI had a higher percentage of previous coronary artery bypass grafting (CABG), right coronary occlusion and side branch occlusion, and technical success was lower in the PMI group (90.4% vs. 96.7%, P = 0.003). One‐year MACE‐free survival was reduced in the PMI group (87.8% vs. 95.9%, P = 0.001). The final TIMI flow 0–1 (OR 2.23, 95%CI 1.06–4.87, P = 0.02), side branch occlusion (OR 2.67, 95%CI 1.19–7.11, P = 0.009), retrograde PCI (OR 1.35, 95%CI 1.10–2.74, P = 0.04), and history of prior CABG (OR 2.41, 95%CI 1.38–5.91, P = 0.01) were independent risk factors for the occurrence of PMI.ConclusionsIn this unique Chinese cohort, PMI post CTO PCI was associated with several clinical and angiographic factors and exerts an adverse effect on 1‐year clinical outcomes. © 2016 Wiley Periodicals, Inc.
ChemInform Abstract: Oxychalcogenide BaGeOSe2: Highly Distorted Mixed‐Anion Building Units Leading to a Large Second‐Harmonic Generation Response.
Authors: Liu Bin‐Wen , Jiang Xiao‐Ming , Wang Guan‐E , Zeng Hui‐Yi , Zhang Ming‐Jian , Li Shu‐Fang , Guo Wei‐Huan , Guo Guo‐Cong 
Published: February 2016

AbstractSingle crystals of BaGeOSe2 are prepared by solid state reaction of a stoichiometric mixture of GeO2, Ba, Se, and extra KI as a flux (evacuated quartz tubes, 1.
ChemInform Abstract: Early‐Lanthanide(III) Acetonitrile—Solvento Adducts with Iodide and Noncoordinating Anions.
Authors: Brown Jessie L. , Davis Benjamin L. , Scott Brian L. , Gaunt Andrew J. 
Published: February 2016

AbstractDissolution of LnI3 (Ln: La, Ce) in MeCN (25 °C) results in the highly soluble solvates LaI3(MeCN)5 (I) and CeI3(MeCN)5 (II) in 72‐84% yield.
ChemInform Abstract: A Modularly Designed Supramolecular Organocatalyst as an Effective Stimulant for the Highly Asymmetric Michael Addition of Ketones to Nitro Olefins.
Authors: Ramachary Dhevalapally B. , Shruthi Kodambahalli S. , Madhavachary R. 
Published: February 2016

AbstractAn acid promoted cyclization of the products to medicinally important tetrahydroacridines is also demonstrated.
ChemInform Abstract: Efficient Synthesis of π‐Conjugated Molecules Incorporating Fluorinated Phenylene Units Through Palladium‐Catalyzed Iterative C(sp2)—H Bond Arylations.
Authors: Abdelmalek Fatiha , Derridj Fazia , Djebbar Safia , Soule Jean‐Francois , Doucet Henri 
Published: February 2016

AbstractThe title synthesis starts from heteroarenes and furnishes the products in two or three steps following Pd‐catalyzed desulfitative arylation and direct arylations using aryl bromides sequence.
ChemInform Abstract: Selective Rhodium‐Catalyzed Reduction of Tertiary Amides in Amino Acid Esters and Peptides.
Authors: Das Shoubhik , Li Yuehui , Bornschein Christoph , Pisiewicz Sabine , Kiersch Konstanze , Michalik Dirk , Gallou Fabrice , Junge Kathrin , Beller Matthias 
Published: February 2016

AbstractA highly selective reduction of N‐acylated amino acid derivatives to the corresponding N‐alkylated products is developed using PhSiH3 in the presence of a Rh(II)‐catalyst.
ChemInform Abstract: Novel One‐Pot Three‐Component Reaction for the Synthesis of Functionalized Spiroquinazolinones.
Authors: Tajbakhsh Mahdieh , Ramezanpour Sorour , Balalaie Saeed , Bijanzadeh Hamid Reza 
Published: February 2016

Abstract8 Title compounds are prepared by a one‐pot three‐component reaction.
ChemInform Abstract: Synthesis of 2,5‐Dihydrofurans via a Gold(I)‐Catalyzed Formal [4 + 1] Cycloaddition of α‐Diazoesters and Propargyl Alcohols.
Authors: Wang Jing , Yao Xinbo , Wang Tao , Han Jie , Zhang Jin , Zhang Xi , Wang Ping , Zhang Zunting 
Published: February 2016

AbstractThe reaction succeeds using various aryl substituted α‐diazoesters and aryl‐ as well as alkyl‐substituted propargylic alcohols, including compounds with two propargylic alcohol moieties.
ChemInform Abstract: Friedel—Crafts Hydroxyalkylation of Indoles Mediated by Trimethylsilyl Trifluoromethanesulfonate.
Authors: Downey C. Wade , Poff Christopher D. , Nizinski Alissa N. 
Published: February 2016

AbstractFriedel‐Crafts silyloxyalkylation of indoles and their subsequent deprotection yield 1:1 adducts of indoles and aldehydes.
ChemInform Abstract: Highly Efficient Organocatalyzed Conversion of Oxiranes and CO2 into Organic Carbonates.
Authors: Sopena Sergio , Fiorani Giulia , Martin Carmen , Kleij Arjan W. 
Published: February 2016

AbstractA binary catalyst system based on tannic acid/NBu4I is presented as a highly efficient organocatalyst at very low catalyst loading for the coupling of carbondioxide and functional oxiranes to afford cyclic carbonates in good yields.
ChemInform Abstract: Diastereoselective Construction of anti‐4,5‐Disubstituted‐1,3‐dioxolanes via a Bismuth‐Mediated Two‐Component Hemiacetal Oxa‐Conjugate Addition of γ‐Hydroxy‐α,β‐unsaturated Ketones with Paraformaldehyde
Authors: Grisin Aleksandr , Oliver Samuel , Ganton Michael D. , Bacsa John , Evans P. Andrew 
Published: February 2016

AbstractThe obtained dioxolanes (III) can be subjected to stereodivergent reductions to afford syn,syn and syn,anti‐1,2,4‐triols (IV) and (V), respectively.
ChemInform Abstract: Gold‐Catalyzed Stereoselective 1,4‐Conjugate Addition of Pyrazoles to Propiolates and Their Hydrogenation to β‐Pyrazolyl Acid Esters.
Authors: Luo Guanglin , Chen Ling 
Published: February 2016

AbstractThe optimized conditions allow the conjugate addition of pyrazoles to propiolates under microwave irradiation and conventional heating.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of 1H‐Pyrazolo[4,3‐c]quinolines and 4‐Anilinoquinoline‐3‐carbonitriles from 4‐Chloroquinoline‐3‐carbaldehydes.
Authors: Wang Chao , Tang Caifei , Li Zhiming , Wang Quanrui 
Published: February 2016

AbstractThe title quinolines are obtained as a mixture of products by palladium‐catalyzed intramolecular C—N bond formation and concurrent hydrazine N—N bond fission.
ChemInform Abstract: Copper‐Mediated Aerobic Oxidative Synthesis of Benzimidazo Fused Quinazolines via a Multicomponent Approach.
Authors: Rai Byanju , Kumar Promod , Kumar Atul 
Published: February 2016

AbstractThe synthesis of the title quinazolines involves the formation of three C—N bonds starting from the azidation of the haloaryl educts with sodium azide followed by in situ conversion of these azides into aryl amines, which on condensation with various benzaldehydes undergo oxidative cyclization affording benzimidazo[1,2‐c]quinazoline derivatives in good to excellent yields.
ChemInform Abstract: Broensted Acid‐Promoted [3 + 3] Cycloaddition of Azomethine Ylides with Quinonemonoimine: A Practical Method Towards Dihydrobenzoxazine Derivatives.
Authors: Wu Yang , Qiao Guanyu , Liu Honglei , Zhang Lei , Sun Zhanhu , Xiao Yumei , Guo Hongchao 
Published: February 2016

AbstractThe reaction can be carried out on the gram scale.
ChemInform Abstract: A Metal Catalyst‐Free and One‐Pot Synthesis of (3,4‐Dihydro‐2H‐benzo[b][1,4]oxazin‐2‐yl)methanol Derivatives in Water
Authors: Singh Shambhu Nath , Jayaprakash Sarva , Venkateshwara Reddy K. , Nakhi Ali , Pal Manojit 
Published: February 2016

Abstractstarting from various aminophenols and epichlorhydrin
ChemInform Abstract: Organosulfide‐Catalyzed Diboration of Terminal Alkynes under Light.
Authors: Yoshimura Aya , Takamachi Yuki , Han Li‐Biao , Ogawa Akiya 
Published: February 2016

AbstractDiaryl disulfides such as (PhS)2 are useful organocatalysts for the photolytic addition of bis(pinacolato)diboron to terminal alkynes.
ChemInform Abstract: Antioxidative Cassane Diterpenoids from the Seeds of Caesalpinia minax
Authors: Zhang Jun‐Sheng , Guo Yan‐Qiong , Bao Jing‐Mei , Jiang Min‐Hong , Lin Shu‐Ling , Su Zhi‐You , Tang Gui‐Hua , Yin Sheng 
Published: February 2016

Abstractisolation, structural elucidation, and antioxidative properties of five new cassane diterpenoids, caesalmins I‐M, along with 23 known analogues
ChemInform Abstract: Biflavones and Furanone Glucosides from Zabelia tyaihyonii
Authors: Jang Hari , Lee Jin Woo , Jin Qinghao , Kim Soo‐Young , Lee Dongho , Hong Jin Tae , Kim Youngsoo , Lee Mi Kyeong , Hwang Bang Yeon 
Published: February 2016

Abstractisolation and structure elucidation of two new axially chiral biflavones (I) and two new furanone glycosides, zabeliosides A and B (II)
ChemInform Abstract: Corrin Syntheses. Part 2. Synthesis of Corrin Complexes via (A→B) Ring Closure. Preparation of Hemicorrinoid B/C‐Components, and Model Studies on Enamides and Imido Ester C,C Condensations
Authors: Scheffold Rolf , Bertele Erhard , Gschwend Heinz , Haeusermann Werner , Wehrli Pius , Huber Willi , Eschenmoser Albert 
Published: February 2016

AbstractReview: [91 refs.
ChemInform Abstract: Corrin Syntheses. Part 3. Synthesis of Corrin Complexes via (A→B) Ring Closure. Preparation of A/D Components
Authors: Pesaro Mario , Elsinger Fritz , Boos Helmut , Felner‐Cabogy Ivo , Gribi Hanspeter , Wick Alexander , Gschwend Heinz , Eschenmoser Albert 
Published: February 2016

AbstractReview: [79 refs.
Effect of genotype and genotype by environment interaction on total cyanide content, fresh root, and starch yield in farmer‐preferred cassava landraces in Tanzania
Authors: Mtunguja Mariam K. , Laswai Henry S. , Kanju Edward , Ndunguru Joseph , Muzanila Yasinta C. 
Published: February 2016

AbstractHigh starch yield is the most important trait for commercialized cassava starch production. Furthermore, cyanide present in cassava roots poses a health challenge in the use of cassava for food. Cassava genotypes have varying maturity periods that are also environmental dependent. This study aimed at identifying suitable cultivars and optimum time of harvest to maximize starch production across three environments. The study found significant difference between genotypes, locations, harvest period, and all the interactions (P ≤ 0.001) for all traits analyzed. Kiroba recorded high starch yields of 17.4, 12.7, and 8.2 t ha−1 at Chambezi, Amani, and Magadu, respectively. Kilusungu recorded highest cyanide content of 300–400 ppm across all locations but Kiroba recorded highest values of 800 ppm, 15 months after planting at Chambezi. Genotype by environment (GGE) biplot analysis revealed that Kiroba was a superior cultivar in terms of starch yield. Kilusungu recorded highest cyanide content and average starch yield, therefore suitable for use in starch production. The study confirmed effect of genotype and genotype by environment interaction, Kiroba cultivar was superior in terms of starch yield and maximum starch yield was obtained at 9 months after planting. Nyamkagile and Kibandameno had the lowest cyanide content across all environments.
Effects of a multilayered DNA/protamine coating on titanium implants on bone responses
Authors: Sakurai Toshitsugu , Yoshinari Masao , Toyama Takeshi , Hayakawa Tohru , Ohkubo Chikahiro 
Published: February 2016

AbstractDNA coating on dental titanium (Ti) implants is attracting attention due to its osteogenic properties. The aim of the present study was to evaluatein vitroandin vivobioactivities of a multilayered DNA/protamine (D/P) coating on Ti implant by simulated body fluid (SBF) immersion experiments and implantation experiments into extracted sockets of rat molars. Two types of DNA, 300 base pair (bp) and 7000 bp fragments, were used. Protamine was initially immobilized onto Ti implants using a tresyl chloride‐activated method and DNA and protamine were then alternatively deposited after the immobilization of protamine by a layer‐by‐layer technique. A multilayered D/P‐coating was confirmed by X‐ray photoelectron spectroscopy and Fourier‐transform infrared spectroscopy measurements. The deposition of apatite progressed more on the surfaces of multilayered D/P‐coated Ti implants than on those of nontreated Ti implants in SBF immersion experiments. Animal implantation experiments showed that multilayered D/P‐coated Ti implants provided a significantly higher bone‐to‐implant (BIC) contact ratio 3 weeks after implantation. No significant difference was observed in the BIC ratio 9 weeks after implantation. The results of the present study demonstrated that a multilayered D/P‐coating promoted new bone formation at the early stages of the bone healing process. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1500–1509, 2016.
Suture materials — Current and emerging trends
Authors: Dennis Christopher , Sethu Swaminathan , Nayak Sunita , Mohan Loganathan , Morsi Yosry (Yos) , Manivasagam Geetha 
Published: February 2016

AbstractSurgical sutures are used to facilitate closure and healing of surgical‐ or trauma‐induced wounds by upholding tissues together to facilitate healing process. There is a wide range of suture materials for medical purpose and the main types include absorbable and nonabsorbable. Recently, there is a growth in the development of classes of suture materials based on their properties and capabilities to improve tissue approximation and wound closure. This review outlines and discusses the current and emerging trends in suture technology including knotless barbed sutures, antimicrobial sutures, bio‐active sutures such as drug‐eluting and stem cells seeded sutures, and smart sutures including elastic, and electronic sutures. These newer strategies expand the versatility of sutures from being used as just a physical entity approximating opposing tissues to a more biologically active component enabling delivery of drugs and cells to the desired site with immense application potential in both therapeutics and diagnostics. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1544–1559, 2016.
Multi and mixed 3D‐printing of graphene‐hydroxyapatite hybrid materials for complex tissue engineering
Authors: Jakus Adam E. , Shah Ramille. N. 
Published: February 2016

AbstractWith the emergence of three‐dimensional (3D)‐printing (3DP) as a vital tool in tissue engineering and medicine, there is an ever growing need to develop new biomaterials that can be 3D‐printed and also emulate the compositional, structural, and functional complexities of human tissues and organs. In this work, we probe the 3D‐printable biomaterials spectrum by combining two recently established functional 3D‐printable particle‐laden biomaterial inks: one that contains hydroxyapatite microspheres (hyperelastic bone, HB) and another that contains graphene nanoflakes (3D‐graphene, 3DG). We demonstrate that not only can these distinct, osteogenic, and neurogenic inks be co‐3D‐printed to create complex, multimaterial constructs, but that composite inks of HB and 3DG can also be synthesized. Specifically, the printability, microstructural, mechanical, electrical, and biological properties of a hybrid material comprised of 1:1 HA:graphene by volume is investigated. The resulting HB‐3DG hybrid exhibits mixed characteristics of the two distinct systems, while maintaining 3D‐printability, electrical conductivity, and flexibility. In vitro assessment of HB‐3DG using mesenchymal stem cells demonstrates the hybrid material supports cell viability and proliferation, as well as significantly upregulates both osteogenic and neurogenic gene expression over 14 days. This work ultimately demonstrates a significant step forward towards being able to 3D‐print graded, multicompositional, and multifunctional constructs from hybrid inks for complex composite tissue engineering. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 274–283, 2017.