bluuebunny/crossref_metadata_2025_split huggingface dataset:
I Dentification Immunohistological Changes in the Thymus Gland of Male and Female Rats With Indocrine Glands Disorder
Authors: Stafa H.Ali  , N.Salman Ali 
Published: October 2024

Endocrine disorders is the result of a hormone imbalance, a condition characterized by a gland producing too much or too little of a hormone. This imbalance can be caused by:Issues with the endocrines feedback system−its main job is to keep hormones in the body perfectly balanced but it can malfunction and cause an imbalance a genetic disorder or infection or disease or injury to an an endocrine gland.The study amied to know the changes that occur in the thymus gland as a result of endocrine disorders in order to explain and analyze them accurately,as well as an immunological comparison between males and females.Twenty−four male and female rats Rattus norvegicus were divided into three groups of eight rats each : The first group (G1) received normal saline for 21 dayꓼ The second group male(G2), rats were given 6 mg / kg metoclopramide by intraperitoneal injection for hyperprolactinemia induction for 21 daysꓼ The third group femals (G3)was given metoclopramide 6 mg / kg intraperitoneally to induce hyperprolactinemic rats.After the end of experimental [21 days ], Measure prolactin hormone, and the thymus gland was removed, processed and examine for histomorphological changes. The result of the study revealed that is a significant (p<0.05) in prolactin and( WBC) in the two hyperprolactinemia group when compared with the control group.And when compared a group of hyperprolactinemia the males and agroup hyperprolactin females.Note a significant difference(increase)in the male group compared to the female group.And the resuit of the study showed asignificant decrease(p<0.05) in weight and size the thymus gland in hyperprolactinemia male and female group compared with the control group.The histologicale study in male and female laboratory rats of the two hyperprolactinemia group also showed clear histological changes compared to the negative control group,reprsented the cortex area increased compared with the medulla area ,where the cortex−to−medulla ratio was about 3:1 .The limited numbers of epithelial cells were observed in the medulla area where the increase in lymphocyte numbers was significantly observed.Also, Hassall‘s corpuscles were not observed in the medulla.AS note the limited deposition or almost absence of collagen fibre in the medulla area.The study concluded endocrine disruption has a significant and noticeable effect on the size and weight of the thymus gland on the one hand and a histological effect on the other hand.
Efektivitas Model Blended Learning Menggunakan Cisco Packet Tracer Untuk Meningkatkan Hasil Belajar Peserta Didik Di SMK Negeri 7 Makassar
Authors: Syahrul  , Jaya Hendra , Manguling Inez Sri Wahyuningsi 
Published: October 2024

Penelitian ini bertujuan untuk mengetahui bagaimana efektivitas pembelajaran dengan model blended learning menggunakan cisco packet tracer ditinjau dari hasil belajar peserta didik di SMK Negeri 7 Makassar. Populasi dalam penelitian ini adalah seluruh peserta didik XI RPL SMK Negeri 7 Makassar, sedangkan sampelnya berjumlah 46 orang yang teridri dari kelas XI RPL 1 sebagai kelas eksperimen dan kelas XI RPL 2 sebagai kelas kontrol. Jenis penelitian ini merupakan penelitian kuasi eksperimen. Penelitian ini dilaksanakan dengan membagi peserta didik kedalam 2 kelompok yaitu kelas eksperimen dan kelas kontrol. Data penelitian diperoleh dengan memberikan tes hasil belajar berupa pretest dan posttest. Teknik analisis data yang digunakan adalah uji normalitas, uji homogenitas dan uji independent sample t-test. Hasil penelitian menunjukkan dalam pelaksanaan pembelajaran kelas eksperimen ternyata memberikan dampak positif terhadap hasil belajar peserta didik dimana ada perbedaan signifikan pembelajaran model blended menggunakan cisco packet tracer. Nilai rata-rata hasil belajar kelas eksperimen peserta didik antara sebelum dan sesudah mendapatkan perlakuan mengalami kenaikan. Sebelum diterapkan model blended learning menggunakan cisco packet tracer nilai pretest peserta didik sebesar 43,48. Setelah menerapkan model blended learning menggunakan cisco packet tracer nilai posttest peserta didik sebesar 81,5. Nilai rata-rata hasil belajar peserta didik kelas kontrol yang tidak mendapatkan perlakuan dengan tidak menerapkan model blended learning yaitu nilai pretest peserta didik sebesar 37,83 dan nilai posttest peserta didik sebesar 72,39. Perbandingan nilai pretest dan posttest kelas eksperimen setelah diberikan perlakuan dengan menerapkan model pembelajaran blended menggunakan cisco packet tracer terjadi peningkatan nilai yang signifikan. Peningkatan nilai pada kelas eksperimen dapat disimpulkan adanya efektivitas model blended learning menggunakan cisco packet tracer untuk meningkatkan hasil belajar terhadap peserta didik di SMK Negeri 7 Makassar.
Voz e presença
Authors: Mota Juliana 
Published: October 2024

O artigo pretende questionar como a investigação dos caminhos da memória pode afetar o trabalho vocal do ator, expandindo sua presença cênica. Intuímos que a busca e a utilização dos arquétipos sonoros são via de transformação do estado do ator, da emanação do ser e, consequentemente, da relação de troca que acontece entre ator e espectador no momento da partilha cênica. Com base em experiências vivenciadas no grupo de pesquisa Casa Aberta, vinculado ao curso de Teatro da Universidade Federal de São João del-Rei, podemos identificar um desenho metodológico que será apresentado neste artigo como ferramenta pedagógica na busca da transformação da presença cênica do ator.
A opereta francesa
Authors: Neves Larissa de Oliveira 
Published: October 2024

Este artigo se propõe a delinear alguns aspectos da formação e das convenções da opereta (1850 - 1870), gênero originário da França, mas que percorreu o mundo e teve um papel fundamental na história do teatro brasileiro. Ao trazer essas informações inéditas para o pesquisador brasileiro, o artigo se propõe a refletir sobre alguns aspectos do gênero que ajudam a compreender por que essas peças fizeram tanto sucesso no Brasil e foram abrasileiradas de uma maneira tão singular — a ponto de as operetas nacionais gerarem frutos que determinariam os rumos do teatro brasileiro nas décadas seguintes.
Butô
Authors: Baird Bruce 
Published: October 2024

Artigo ligeiramente adaptado pelo autor e traduzido do originalmente publicado, sob o mesmo título, em A Processive Turn: The Video Aesthetics of Edin Vélez. Editado por Jorge Daniel Veneciano. RUTGERS, NJ: Paul Robison Galleries, 2007, p.42-49. Este capítulo foi gentilmente cedido pela editora. A reprodução é permitida apenas com a autorização expressa da mesma.
Saliva as a diagnostic tool in soccer: a scoping review
Authors: Ferreira Joyce , Jimenez Manuel , Cerqueira Agatha , Rodrigues da Silva Joana , Souza Bruno , Berard Lucas , Bachi Andre L.L. , Dame-Teixeira Naile , Coto Neide , Heller Debora 
Published: October 2024

Background
A high-performance sport like soccer requires training strategies that aim to reach peak performance at the right time for the desired competitions. Thus, the investigation of biochemical markers in saliva is a tool that is beginning to be used in athletes within the physical training process. There is still no evidence on universal saliva collection and analysis protocols in soccer. This review aims to map the use of saliva as a tool for analyzing athletic performance in soccer, from the biomarkers used to the validated protocols for these analyses.

Methods
A broad systematic literature search was carried out in the electronic databases Web of Science, Livivo, Scopus, PubMed, LILACS and gray literature (Google Scholar and ProQuest). Two reviewers selected the studies and extracted data on the type of salivary collection used, the salivary biomarker evaluated and monitored.

Results
Ninety-three articles were included. The most frequently analyzed salivary biomarkers were cortisol (n = 53), testosterone (n = 35), secretory immunoglobulin A (SIgA) (n = 33), salivary alpha amylase (n = 7), genetic polymorphisms (n = 4) and miRNAs (n = 2). The results of the studies indicated beneficial effects in monitoring salivary biomarkers in the assessment of sports performance, although most studies did not include a control group capable of comparison. Salivary collection and analysis protocols were varied and commonly not reported.

Conclusions
This scoping review provides a comprehensive overview of the current landscape of salivary biomarker research in soccer. The findings underscore the importance of these biomarkers in assessing athletes’ physiological responses and overall well-being. Future research should focus on refining methodologies, exploring additional biomarkers, and investigating the practical implications of salivary biomarker monitoring in soccer and other sports.
The impact of scabies in tent cities in Kahramanmaraş after the Turkish earthquakes: oral pharmacologic treatment efficacy
Authors: Beyoğlu Muhammed Mustafa , Gokler Mehmet Enes 
Published: October 2024

Background
Our study was conducted to determine the impact of scabies in people living in collective living areas such as tent cities and container cities after the February 6 Kahramanmaraş earthquakes and to show the effectiveness of oral ivermectin treatment on scabies cases because topical treatments could not be used in this period when access to water was limited.

Methods
Among 233 patients diagnosed and treated with scabies in tent and container cities, 192 patients who met the criteria were included in the study. Descriptive statistics were given as number (n), percentage (%), mean, median, standard deviation (SD). In the comparison of categorical data, the chi-square test was applied; in the comparison of numerical data ANOVA analyses was applied.

Results
A total of 192 scabies patients (82.4%), 47.9% (N:92) of whom were women, were included in the study. The frequency of scabies in the total population in tent cities and container cities was found to be at least 0.54%. The most common symptoms were pruritis (99.0%) and rash (97.9%). The most common sites of lesion involvement were the umbilicus (87.0.%), forearm (75.0%), and back (70.3%). After the first dose of ivermectin, 159 (82.8%) patients showed complete recovery, while 30 (15.6%) patients showed partial recovery. 3 (1.6%) patients showed no improvement. After the second dose of ivermectin, 173 (90.1%) patients showed complete recovery. There were two (1.0%) patients who did not show improvement after two doses. Due to the deterioration of urban infrastructure after devastating earthquakes, the irregularity of mass living areas, the lack of hygiene conditions, and the difficulty of accessing clean, usable water, oral ivermectin may be the first choice for treatment in terms of ease of use and effectiveness.
Identification of an additive interaction using parameter regularization and model selection in epidemiology
Authors: Hu Chanchan , Lin Zhifeng , Hu Zhijian , Lin Shaowei 
Published: October 2024

Background
In epidemiology, indicators such as the relative excess risk due to interaction (RERI), attributable proportion (AP), and synergy index (S) are commonly used to assess additive interactions between two variables. However, the results of these indicators are sometimes inconsistent in real world applications and it may be difficult to draw conclusions from them.

Method
Based on the relationship between the RERI, AP, and S, we propose a method with consistent results, which are achieved by constraining $e^{\theta_3}-e^{\theta_1}-e^{\theta_2}+1=0$, and the interpretation of the results is simple and clear. We present two pathways to achieve this end: one is to complete the constraint by adding a regular penalty term to the model likelihood function; the other is to use model selection.

Result
Using simulated and real data, our proposed methods effectively identified additive interactions and proved to be applicable to real-world data. Simulations were used to evaluate the performance of the methods in scenarios with and without additive interactions. The penalty term converged to 0 with increasing λ, and the final models matched the expected interaction status, demonstrating that regularized estimation could effectively identify additive interactions. Model selection was compared with classical methods (delta and bootstrap) across various scenarios with different interaction strengths, and the additive interactions were closely observed and the results aligned closely with bootstrap results. The coefficients in the model without interaction adhered to a simplifying equation, reinforcing that there was no significant interaction between smoking and alcohol use on oral cancer risk.

Conclusion
In summary, the model selection method based on the Hannan-Quinn criterion (HQ) appears to be a competitive alternative to the bootstrap method for identifying additive interactions. Furthermore, when using RERI, AP, and S to assess the additive interaction, the results are more consistent and the results are simple and easy to understand.
O RECONTO ORAL E A COMPREENSÃO EM LEITURA
Authors: Cordeiro da Silva Giseli , Baretta Luciane 
Published: October 2024

Os dados de avaliações que mensuram a compreensão leitora de escolares do Ensino Fundamental e Médio apontam para níveis insatisfatórios evidenciando o fato de que o ensino da leitura e sua compreensão necessitam de um olhar ainda mais atento. Assim, a partir de uma abordagem qualitativa, buscou-se uma reflexão sobre o conhecimento dos principais processos e fatores que influenciam a leitura e sua relação com o Reconto Oral, um instrumento já consolidado para avaliação da compreensão em leitura. Com este procedimento bem-organizado e planejado, o leitor pode alcançar níveis de compreensão mais aprofundados, pois esse instrumento possibilita uma maior interação com o texto conduzindo o leitor ao nível da leitura autônoma e crítica. A aplicação do Reconto Oral de forma planejada a se observar os fatores influentes na compreensão leitora contribui para que os professores consigam observar as habilidades e dificuldades em leitura e, por consequência, direcionar seus planejamentos contribuindo com os escolares a fim de evoluir na compreensão de um texto.
An open Web application framework for peer‐to‐peer location‐based services
Authors: Brambilla Giacomo , Amoretti Michele , Zanichelli Francesco 
Published: August 2017

SummaryMobile applications are increasingly taking advantage of sophisticated Location‐Based Services (LBSs). Currently, most available LBSs rely upon centralized infrastructures, thus raising serious concerns as regards user privacy. Because of that, researchers proposed a number of interesting decentralized, peer‐to‐peer protocols for LBSs, although their effectiveness and efficiency was mostly evaluated only by means of simulations. Even when prototypes have been realized, performance results cannot be replicated or extended due to nonpublicly available or closed software. This paper aims at improving the state of the art by presenting both simulations and field tests results for our Adaptive Distributed Geographic Table (ADGT) overlay scheme. The field tests have been carried out in our University Campus by sets of students using mobile applications based on Adgt.js, a novel and truly cross‐platform, WebRTC‐based framework for the development of ADGT‐based peer‐to‐peer LBSs. The tested LBS example, ie, a messaging mobile app based on Adgt.js, illustrates how straightforward and capable such a framework is.
Honey bee‐collected pollen in agro‐ecosystems reveals diet diversity, diet quality, and pesticide exposure
Authors: Colwell Megan J. , Williams Geoffrey R. , Evans Rodger C. , Shutler Dave 
Published: August 2017

AbstractEuropean honey bees Apis mellifera are important commercial pollinators that have suffered greater than normal overwintering losses since 2007 in North America and Europe. Contributing factors likely include a combination of parasites, pesticides, and poor nutrition. We examined diet diversity, diet nutritional quality, and pesticides in honey bee‐collected pollen from commercial colonies in the Canadian Maritime Provinces in spring and summer 2011. We sampled pollen collected by honey bees at colonies in four site types: apple orchards, blueberry fields, cranberry bogs, and fallow fields. Proportion of honey bee‐collected pollen from crop versus noncrop flowers was high in apple, very low in blueberry, and low in cranberry sites. Pollen nutritional value tended to be relatively good from apple and cranberry sites and poor from blueberry and fallow sites. Floral surveys ranked, from highest to lowest in diversity, fallow, cranberry, apple, and blueberry sites. Pesticide diversity in honey bee‐collected pollen was high from apple and blueberry sites and low from cranberry and fallow sites. Four different neonicotinoid pesticides were detected, but neither these nor any other pesticides were at or above LD50 levels. Pollen hazard quotients were highest in apple and blueberry sites and lowest in fallow sites. Pollen hazard quotients were also negatively correlated with the number of flower taxa detected in surveys. Results reveal differences among site types in diet diversity, diet quality, and pesticide exposure that are informative for improving honey bee and land agro‐ecosystem management.
A Utopian Commentary on the Plight of Nigeria: Ken Saro-Wiwa’s “Africa Kills Her Sun”
Authors: Rodrigues Angela L. 
Published: August 2017

Abstract:This article investigates the presence of utopian elements in Ken Saro-Wiwa’s short story “Africa Kills Her Sun,” and the extent to which they dismantle an otherwise bleak commentary on the protagonist’s reality. Ernst Bloch’s notions of “pre-illumination,” “daydreaming,” and “not-yet” are employed as analytical tools in order to unravel the narrative’s utopian content.
Is More than One Hour of Selective Antegrade Cerebral Perfusion in Moderate-to-Mild Systemic Hypothermic Circulatory Arrest for Surgery of Acute Type A Aortic Dissection Safe?
Authors: Papadopoulos Nestoras , Risteski Petar , Hack Theresa , Ay Mahmut , Moritz Anton , Zierer Andreas , El-Sayed Ahmad Ali 
Published: August 2017

Objectives Surgery for acute type A aortic dissection (AAD) remains a surgical challenge with considerable risk of morbidity and mortality. Antegrade cerebral perfusion (ACP) has been popularized, offering a more physiologic method of brain perfusion during complex aortic arch repair, often necessary in setting of AAD. The safe limits of this approach under moderate-to-mild systemic hypothermic circulatory arrest (≥ 28°C) are yet to be defined. Thus, the current study investigates our clinical results after surgical treatment for AAD in patients with a selective ACP and systemic circulatory arrest time of ≥ 60 minutes in moderate-to-mild hypothermia (≥ 28°C).
Methods Between January 2000 and April 2016, 63 consecutive patients underwent surgical treatment for AAD employing selective ACP during moderate-to-mild systemic hypothermia (≥ 28°C) with prolonged ACP and circulatory arrest times. Patients' mean age was 59 ± 15 years, and 39 patients (62%) were men. Hemiarch replacement and total arch replacement were performed in 13 (21%) and 50 (79%) patients, respectively. Frozen elephant trunk, arch light, and elephant trunk technique were performed in nine (14%), six (10%), and three patients (5%), respectively. Clinical data were prospectively entered into our institutional database. Mean late follow-up was 6 ± 4 years and was 98% complete.
Results Cardiopulmonary bypass time accounted for 245 ± 81 minutes and the myocardial ischemic time accounted for 140 ± 43 minutes. Mean duration of ACP was 74 ± 12 minutes. The mean lowest core temperature accounted for 28.9 ± 0.8°C. Unilateral ACP was performed in 44 patients (70%); bilateral ACP was used in the remaining 19 patients (30%). Intensive care unit stay reached 6 ± 5 days. New onset of acute renal failure requiring hemofiltration was observed in 8% of patients (n = 5). New postoperative permanent neurologic deficits were found in five patients (8%) and transient neurologic deficits in six patients (10%). There was one case of paraplegia. Thirty-day mortality and in-hospital mortality were 8 (n = 5) and 11% (n = 7), respectively. Overall survival at 5 years was 76 ± 9%.
Conclusion Our preliminary data suggest that selective ACP during moderate-to-mild systemic hypothermic circulatory arrest (≥ 28°C) can safely be applied for more than 1 hour even in the setting of AAD.
Anxiety and Depression in Patients Undergoing Mitral Valve Surgery: A Prospective Clinical Study
Authors: Botzet Katrin , Dalyanoglu Hannan , Schäfer Ralf , Lichtenberg Artur , Schipke Jochen , Korbmacher Bernhard 
Published: August 2017

Background Impending cardiac surgery presents an existential experience that may induce psychological trauma. Moreover, quality of life long after successful coronary artery bypass graft surgery (CABG) can be impaired.
Aim The aim of this study was to describe the time course of anxiety and depression in patients undergoing mitral valve surgery and compare it with our earlier results of patients undergoing CABG, a disease that is likely to be related to psychosomatic disorders. We hypothesized that patients undergoing mitral valve surgery can better manage stresses of cardiac surgery than patients undergoing CABG.
Patients and Methods Of 117 patients undergoing mitral valve surgery, 100 patients (22 to 87 years; 53 females) completed the study and were interviewed before (pre), 1 week after (early), and 6 months after (late) surgery. The Hospital Anxiety and Depression Scale (HADS) was employed.
Results The proportion of patients with elevated anxiety scores (AS ≥ 8) was higher than normal (19.8%): pre, 33.0%; early, 28.0%; and was normalized late (18.0%). Similarly, depression scores (DS ≥ 8) were increased: pre, 15.0%; early, 20.0%; and late 14.0%, respectively (normal: 3.2%).
Conclusion Coronary heart disease of CABG patients is presented as a systemic disorder, associated with both higher and postoperatively increased distress levels than in mitral valve patients. Anxiety and depression should be recognized as possible symptoms of psychosomatic disorders necessitating psychotherapeutic intervention to prevent postoperative depression and warrant patient-perceived surgical outcome that is additionally affected by expectations with respect to treatment and individual coping capacities. HADS is recommended to screen for vulnerable patients in the clinical routine, and psychosomatic support should be provided.
CBFβ initiates the hematopoietic stem cell program without obligatory binding to RUNX
Authors: Ciau-Uitz Aldo , Pinheiro Philip , Kirmizitas Arif , Fernandez Claire , Patient Roger 
Published: August 2017

SUMMARYHematopoietic stem cells (HSCs) emerge from hemogenic endothelium (HE) localised in the embryonic dorsal aorta (DA). Here we show that Runx1, a transcription factor essential for HSC emergence, controls HE establishment in the absence of its non-DNA-binding partner, CBFβ, and that a CBFβ-binding-deficient Runx1 mutant form can activate the HE program in the DA. Nevertheless, CBFβ is also essential for HSC emergence by regulating the specification of definitive hemangioblasts (DHs), the precursors of the DA and HE, in the lateral plate mesoderm where it mediates VEGFA induction by BMP signalling. Surprisingly, no Runx gene is expressed in DHs and the pharmacological inhibition of CBFβ binding to Runx is not detrimental for DH, confirming that CBFβ functions independently of Runx. Thus, we have uncovered, for the first time, that CBFβ regulates gene expression without Runx, breaking the dogma in which CBFβ ‘s gene regulatory functions are strictly dependent on its binding to Runx.HIGHLIGHTSRunx1 and CBFβ play independent roles in the establishment of the HSC lineageRunx1 binding to CBFβ is not required for HE establishmentCBFβ is downstream of BMP and regulates endogenous VEGFA expression in DHBinding to Runx is not obligatory for CBFβ function