bluuebunny/crossref_metadata_2025_split huggingface dataset:
From past to digital time: Bibliometric perspective of worldwide research productivity on robotic and computer-assisted arthroplasty
Authors: Shu Boshen , Ou Xuehai , Shi Shaoyan , Hu Leiming 
Published: October 2024

Objective The number of citations can be used as an impact marker of research work. This study aimed to determine and characterize the worldwide research productivity on robotic and computer-assisted arthroplasty. Methods All accessible publications from 1992 to 2023 on robotic and computer-assisted arthroplasty from Web of Science Core Collection (WOSCC) database were recorded in August 2024. The following aspects were retrieved: cited times, name of author, keywords, institution, country, year of publication, journal, title, topic, impact factor, and H-index. VOSviewer software and Microsoft Excel were conducted to make the bibliometric research visual. The nature of our study is a systematic study and was conducted in China. Results 1061 articles were included in our study. The total cited times were 27,461 with the average number of 26. The most productive year was 2022, with a total of 158 publications. The United States contributed the highest number of articles (n = 389, 36.66%) and the Hospital for Special Surgery (n = 53, 5.00%) held the leading institution. “Orthopedics” became the dominant topic (n = 894, 84.26%) and the latest keywords “clinical outcomes”, “acetabular cup placement”, and “satisfaction” have mainly appeared since 2020. Conclusions Our analysis gives a comprehensive review of related articles on robotic and computer-assisted arthroplasty from past to future. The United States dominated studies of robotic and computer-assisted arthroplasty and a journal about arthroplasty was the most productive one. “Clinical outcomes”, “Acetabular cup placement”, and “Satisfaction” may become the future research hotspots.
Current Applications and Future Implications of Artificial Intelligence in Spine Surgery and Research: A Narrative Review and Commentary
Authors: Yahanda Alexander T. , Joseph Karan , Bui Tim , Greenberg Jacob K. , Ray Wilson Z. , Ogunlade John I. , Hafez Daniel , Pallotta Nicholas A. , Neuman Brian J. , Molina Camilo A. 
Published: October 2024

Study Design Narrative review. Objectives Artificial intelligence (AI) is being increasingly applied to the domain of spine surgery. We present a review of AI in spine surgery, including its use across all stages of the perioperative process and applications for research. We also provide commentary regarding future ethical considerations of AI use and how it may affect surgeon-industry relations. Methods We conducted a comprehensive literature review of peer-reviewed articles that examined applications of AI during the pre-, intra-, or postoperative spine surgery process. We also discussed the relationship among AI, spine industry partners, and surgeons. Results Preoperatively, AI has been mainly applied to image analysis, patient diagnosis and stratification, decision-making. Intraoperatively, AI has been used to aid image guidance and navigation. Postoperatively, AI has been used for outcomes prediction and analysis. AI can enable curation and analysis of huge datasets that can enhance research efforts. Large amounts of data are being accrued by industry sources for use by their AI platforms, though the inner workings of these datasets or algorithms are not well known. Conclusions AI has found numerous uses in the pre-, intra-, or postoperative spine surgery process, and the applications of AI continue to grow. The clinical applications and benefits of AI will continue to be more fully realized, but so will certain ethical considerations. Making industry-sponsored databases open source, or at least somehow available to the public, will help alleviate potential biases and obscurities between surgeons and industry and will benefit patient care.
Prevalence and Clinical Impact of Coronal Malalignment Following Circumferential Minimally Invasive Surgery (CMIS) for Adult Spinal Deformity Correction
Authors: Tanasansomboon Teerachat , Khandehroo Babak , Limthongkul Worawat , Yingsakmongkol Wicharn , Anand Neel 
Published: October 2024

Study Design Retrospective study. Objectives To determine prevalence and clinical importance of patients who had postoperative CM after CMIS for ASD correction. Methods We reviewed patients who underwent CMIS technique. Inclusion criteria were patients who were diagnosed with ASD, which is defined as having at least one of the following: coronal Cobb angle >20, SVA >50 mm, PI-LL >10, PT >20. They underwent >4 spinal levels fusion with CMIS technique and had at least 1-year follow-up. Preoperative and 1-year postoperative radiographs and clinical outcome measures (VAS, ODI, and SRS-22 scores) were used to make the comparisons. Results 120 patients were included. Radiographic outcomes, including CVA, coronal Cobb angle, LSF curve, SVA, LL, and PI-LL, and clinical outcomes, were significantly improved postoperatively in each of the 3 preoperative subgroups (Bao type A, B, and C). At 1-year post-operation, 10 patients (12.4 %) of type A turned out to be CM, 4 patients (21.1%) of type B, and 8 patients (40%) of type C remained CM. Comparing coronally aligned (CA) to coronally mal-aligned patients at 1-year follow-up in each coronal subtype revealed that clinical and radiographic outcomes were comparable. Conclusions CMIS technique significantly improves radiographic and clinical outcomes for ASD patients. Incidence rates of postoperative CM were similar to open surgery. Type C patients were at risk of postoperative CM than types A and B. However, most 1-year outcomes were not significantly different between postoperative CA and CM patients regardless of the preoperative coronal alignment characteristics except ODI scores in type A.
Magnitude of Septic Shock and its Associated Factors Among Critically Ill COVID-19 Patients at Addis Ababa COVID-19 Care Centers, Ethiopia
Authors: Tiruneh Kasie Gebeyehu , Mekonnen Migbar Sibhat , Tsegaw Melsew Getnet , Ashine Taye Mezgebu , Mesfin Edmialem Getahun , Sane Asaminew Habtamu , Beyene Hailu Asmare , Mengstie Melkie Ambaw , Zewude Wuletaw Chane 
Published: October 2024

Background The coronavirus disease (COVID-19) pandemic imposed a major public health impact. Septic shock is one of the frequent complications encountered among critically ill COVID-19 patients, leading to poor healthcare outcomes. This study aimed at assessing the magnitude of septic shock and its associated factors. Methods and materials An institution-based cross-sectional study was conducted retrospectively on 242 randomly selected COVID-19 patients admitted to three Addis Ababa COVID-19 care centers from September 2020 to October 2021. Septic shock was defined as a Sequential Organ Failure Assessment (SOFA) score ≥2 points and persisting hypotension requiring vasopressors to maintain a mean arterial pressure of ≥65 mmHg despite adequate volume resuscitation. Variables in the bivariate analysis were fitted to multiple regression analysis to eliminate confounders and determine independent risk factors for septic shock. In the multivariable analysis, statistical significance was declared at P < .05 Results The prevalence of septic shock was found to be 39.3% (95% confidence interval [CI]: 33.1, 45.7). Advanced age (≥60 years) [AOR = 7.9; 95% CI: 2.3, 26.8], intensive care unit stay above 7 days [AOR = 6.2; 95%CI: 2.1, 18.7], invasive ventilation [AOR = 10; 95% CI: 3, 37], and chronic obstructive pulmonary disease (COPD) [AOR = 18; 95% CI: 7, 45] were significantly associated with increased septic shock among COVID-19 patients. Meanwhile, diabetes [AOR = 0.24; 95% CI: 0.08, 0.71] and cardiovascular diseases [AOR = 0.17; 95% CI: 0.07, 0.44] were associated with a decrease risk of septic shock. Conclusion The prevalence of septic shock in critically ill COVID-19 patients was high and a major concern in this study, and it is independently associated with advanced age, prolonged stay in the intensive care unit, and COPD. Based on these findings, healthcare professionals should closely monitor and manage patients with COVID-19 who have a history of COPD, are older, or prolonged intensive care unit (ICU) stays to prevent septic shock and improve patient outcomes.
The Effect of Jacobson Relaxation Technique on Sleep Quality of Patients With Cancer Under Chemotherapy: A Randomized Clinical Trial
Authors: Kahreh Fatemeh Safari , Abdi Alireza , Khatony Alireza , Salari Nader , Paveh Behnam Khaledi- , Aznab Mozaffar , Naghibzadeh Amirhossein , Mohammadi Mohammad 
Published: October 2024

Introduction Sleep is one of the most crucial basic human needs in Maslow's hierarchy, while sleep disorders are the most commonly occurring complications of chemotherapy. Objective This study was conducted to determine the effect of progressive muscle relaxation techniques on the sleep quality of patients with cancer undergoing chemotherapy. Methods This study was a randomized clinical trial performed on patients with cancer undergoing chemotherapy. Ninety cancer patients were selected by the convenience sampling method and randomly assigned into two groups; the progressive muscle relaxation group and the control group. Before the intervention, the Pittsburgh Sleep Quality Questionnaire (PSQQ) was completed for patients in both groups. In the intervention group, progressive muscle relaxation was performed for 4 weeks (twice daily and 20 min each time). In the control group, patients only received routine care. After the intervention, the PSQQ was completed again for patients in both groups. The data were analyzed using SPSS version 23. Results The mean and standard deviation of age were 45.95 ± 10.26 years. The samples of the intervention and control groups were homogeneous in terms of demographic characteristics. The results showed a significant improvement in the Pittsburgh Sleep Quality Index in the intervention group before and after the intervention ( P < .001, Z = 5.09). However, this rate was not different in the control group. The sleep level of the intervention and control groups was not different at the beginning of the study. However, at the end of the study, the sleep score in the intervention group had decreased significantly ( P < .001, Z = 3.52). Conclusion The results of the present study showed that progressive muscle relaxation improves the sleep quality of patients with cancer undergoing chemotherapy. Therefore, relaxation can be considered a useful and effective intervention for improving sleep quality of patients with cancer.
Evaluating the Effectiveness of Indigenous Health Curricula: Validation and Application of the NOSM CAST Instrument
Authors: Maar Marion , Urajnik Diana , Hudson Geoffrey L. , Manitowabi Darrel , McGregor Lorrilee , Senecal Sam , Strasser Roger , Warry Wayne , Jacklin Kristen 
Published: October 2024

OBJECTIVESIn recent years, Indigenous health curricula have been integrated into medical education in response to international calls to improve Indigenous health care. Instruments to evaluate Indigenous health education are urgently needed. We set out to validate a tool to measure self-reported medical student preparedness to provide culturally safe care to Indigenous Peoples. We then applied the tool to evaluate the effectiveness of the Northern Ontario School of Medicine University's (NOSM U) Indigenous health curriculum.METHODSWe conducted psychometric testing of a 46-item draft NOSM Cultural Competency and Safety Tool (CAST). Testing included principal components analysis, subscale and item analysis, and the use of paired sample t-tests to examine pre- and posttest change to measure learner outcomes. The NOSM CAST was transposed to create a retrospective pre–posttest survey with single-point-in-time scoring.RESULTSRespondents included five cohorts of first-year undergraduate medical students, with 305 of 320 participating (response rate of 95.3%). The validated survey subscales included knowledge, confidence/preparedness, attitudes, intentions for advocacy, antidiscrimination, and self-reflective practice, measured using 36 scale items. Cronbach's alpha showed good to excellent internal consistency for the scales ( α range = 0.82–0.91). Composite reliability values were acceptable. The pre–posttest analysis showed statistically significant increases on four scales: knowledge [ t(254) = 15.10, P < .001], confidence/preparedness [ t(254) = 15.85, P < .001], intentions for advocacy [ t(251) = 3.32, P = .001], and self-reflective practice [ t(254) = 8.04, P < .001]. The largest mean increases were for knowledge ( d = 1.07) and confidence/preparedness ( d = 1.15).CONCLUSIONSThe NOSM CAST tracks student progress in Indigenous health curricula. NOSM U's classroom and immersion-based Indigenous health curriculum enhanced students’ self-reported preparedness for culturally safe care. NOSM CAST implemented together with an assessment of Indigenous patient experiences with the same learners constitutes a rigorous evaluation approach to Indigenous health curricula.
Indeterminate DC histiocytosis is distinct from LCH and often associated with other hematopoietic neoplasms
Authors: Ozkaya Neval , Melloul Benizri Sarah , Venkataraman Girish , Karai Laszlo J. , Fraitag Sylvie , Razanamahery Jérôme , Pittaluga Stefania , Battistella Maxime , Pack Svetlana , Le Pelletier François , Xi Liqiang , Moreau Anne , Lee Ina , Hélias-Rodzewicz Zofia , Donadieu Jean , Haroche Julien , Raffeld Mark , Jaffe Elaine S. , Emile Jean-François 
Published: October 2024

Abstract
Indeterminate dendritic cell histiocytosis (IDCH) is a rare and poorly understood entity characterized by accumulation of CD1a+/S100+ histiocytes (as Langerhans cell histiocytosis [LCH]) but with reduced-absent expression of Langerin/CD207. We assembled 43 cases of IDCH (defined by CD1a+/CD207&lt;20% immunophenotypic profile) examining the clinical, pathologic, and molecular landscape. Median age at presentation was 70 years (interquartile range, 44-80) with cutaneous (31/43; 72%) and nodal (11/43; 26%) involvement predominating. Eighteen (42%) individuals had an associated nonhistiocytic hematopoietic neoplasm (“secondary” IDCH) whereas 7 of 43 (16%) had a concurrent non-IDCH histiocytosis (“mixed” histiocytosis). Most cases exhibited morphology indistinguishable from LCH but with a CD1c+/CSF1R(CD115)− phenotype, mirroring the signature of normal indeterminate cells and conventional DC type 2. Mutational analysis revealed frequent KRAS (13/32; 41%) and BRAF p.V600E (11/36, 31%) mutations that were nearly mutually exclusive. RNA-sequencing analysis uncovered ETV3::NCOA2 fusion in 6 other patients presenting as a sole genetic alteration without any other concurrent histiocytic or hematopoietic neoplasm. BRAF and MAP2K1 alterations were significantly associated with partial/retained (1%-20%) Langerin expression (P = .005) and mixed histiocytosis (P = .002). Remarkably, myeloid alterations (DNMT3A, TET2, and SRSF2) co-occurred in IDCH tissues of several individuals. Paired sequencing of IDCH and concurrent non-IDCH hematopoietic neoplasm in 4 individuals revealed shared mutations. Age at diagnosis and any nodal involvement at diagnosis predicted inferior overall survival, but BRAF/RAS pathway alterations did not affect outcome. These data have implications for the diagnostic evaluation, classification, and therapeutic management of IDCH.
Pathogenic variants inCFAP46,CFAP54,CFAP74andCFAP221cause primary ciliary dyskinesia with a defective C1d projection of the central apparatus
Authors: Wohlgemuth Kai , Hoersting Niklas , Koenig Julia , Loges Niki Tomas , Raidt Johanna , George Sebastian , Cindrić Sandra , Schramm Andre , Biebach Luisa , Lay Simon , Dougherty Gerard W. , Olbrich Heike , Pennekamp Petra , Dworniczak Bernd , Omran Heymut 
Published: October 2024

BackgroundPrimary ciliary dyskinesia is a rare genetic disorder caused by insufficient mucociliary clearance leading to chronic airway infections. The diagnostic guideline of the European Respiratory Society primarily recommends an evaluation of the clinical history (e.g.by the PICADAR prediction tool), nasal nitric oxide production rate measurements, high-speed videomicroscopy analysis of ciliary beating and an assessment of ciliary axonemesviatransmission electron microscopy. Genetic testing can be implemented as a last step.AimsIn this study, we aimed to characterise primary ciliary dyskinesia with a defective C1d projection of the ciliary central apparatus and we evaluated the applicability of the European Respiratory Society diagnostic guideline to this primary ciliary dyskinesia type.MethodsUsing a high-throughput sequencing approach of genes encoding C1d components, we identified pathogenic variants in the novel primary ciliary dyskinesia genesCFAP46andCFAP54, and the known primary ciliary dyskinesia geneCFAP221. To fully assess this primary ciliary dyskinesia type, we also analysed individuals with pathogenic variants inCFAP74.ResultsCareful evaluation revealed that C1d-defective primary ciliary dyskinesia is associated with normal situs composition, normal nasal nitric oxide production rates, normal ciliary ultrastructure by transmission electron microscopy and normal ciliary beating by high-speed videomicroscopy analysis. Despite chronic respiratory disease, PICADAR does not reliably detect this primary ciliary dyskinesia type. However, we could show byin vitrociliary transport assays that affected individuals exhibit insufficient ciliary clearance.ConclusionsOverall, this study extends the spectrum of primary ciliary dyskinesia genes and highlights that individuals with C1d-defective primary ciliary dyskinesia elude diagnosis when using the current diagnostic algorithm. To enable diagnosis, genetic testing should be prioritised in future diagnostic guidelines.
Lung structure and longitudinal change in cardiac structure and function: the MESA COPD Study
Authors: Hermann Emilia A. , Sun Yifei , Hoffman Eric A. , Allen Norrina B. , Ambale-Venkatesh Bharath , Bluemke David A. , Carr J. Jeffrey , Kawut Steven M. , Prince Martin R. , Shah Sanjiv J. , Smith Benjamin M. , Watson Karol E. , Lima Joao A.C. , Barr R. Graham 
Published: October 2024

BackgroundLung structure and cardiac structure and function are associated cross-sectionally. The classic literature suggests relationships of airways disease to cor pulmonale and emphysema to reduced cardiac output (CO) but longitudinal data are lacking.MethodsThe Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study was a multicentre longitudinal COPD case–control study of participants 50–79 years with ≥10 pack-years smoking without clinical cardiovascular disease. Segmental airway wall area (WA) and percent emphysema were measured on computed tomography. Right and left ventricle parameters were assessed on cardiac magnetic resonance imaging (cMRI) in exams 6 years apart. Longitudinal and period cross-sectional associations were evaluated with mixed models adjusted for demographics, body size and smoking.ResultsThe 187 participants with repeated cMRI were 67±7 years old; 42% had COPD; 22% currently smoked; and the race/ethnicity distribution was 54% White, 30% Black, 14% Hispanic and 3% Asian. Greater WA at enrolment was associated with longitudinal increase in right ventricular (RV) mass (3.5 (95% CI 1.1–5.9) g per 10 mm2WA). Greater percent emphysema was associated with stably lower left ventricular (LV) end-diastolic volume (−7.8 (95% CI −10.3– −3.0) mL per 5% emphysema) and CO (−0.2 (95% CI −0.4– −0.1) L·min−1per 5% emphysema).ConclusionCardiac associations varied by lung structure over 6 years in this multi-ethnic study. Greater WA at enrolment was associated with longitudinal increases in RV mass, whereas greater percent emphysema was associated with stable decrements in LV filling and CO.
Acetylxylan esterase is the key to the host specialization of wood-decay fungi predicted by random forest machine-learning algorithm
Authors: Hasegawa Natsuki , Sugiyama Masashi , Igarashi Kiyohiko 
Published: October 2024

AbstractWood-decay fungi produce extracellular enzymes that metabolize wood components such as cellulose, hemicellulose and lignin. Each fungus has a preference of wood species as the host, but identification of these preferences requires a huge amount of cultivation data. Here, we developed a method of predicting the wood species preference, Angiosperm specialist or Gymnosperm specialist or generalist, of wood-decay fungi using the random forest machine-learning algorithm, trained on the numbers of families associated with host specialization in the Carbohydrate-Active enZymes database. The accuracy of the prediction was about 80%, which is lower than that of the classification of white- and brown-rot fungi (more than 98%) by the same method, but the reason for this may be the ambiguity of the definition of “preference” and “generalists”. Carbohydrate esterase (CE) family 1 acetylxylan esterase was the most significant contributor to the prediction of host specialization, followed by family 1 carbohydrate-binding module and CE family 15, mainly containing glucuronoyl esterases. These results suggest that the ability to degrade glucuronoacetylxylan, a major hemicellulose of Angiosperm, is the key factor determining the host specialization of wood-decay fungi.
Autistic and schizotypal traits exhibit similarities in their impact on mentalization and adult attachment impairments: a cross-sectional study
Authors: Sörnyei Dániel , Vass Ágota , Németh Dezső , Farkas Kinga 
Published: October 2024

Abstract
Background
Deficits in mentalizing and attachment occur in the autism and schizophrenia spectrum, and their extended traits in the general population. Parental attachment and the broader social environment highly influence the development of mentalizing. Given the similarities in the symptomatology and neurodevelopmental correlates of autism spectrum disorder (ASD) and schizophrenia (SCH), it is crucial to identify their overlaps and differences to support screening, differential diagnosis, and intervention.

Methods
This cross-sectional study utilized questionnaire data from 2203 adults (65.1% female, mean age[SD] = 37.98[9.66]), including participants diagnosed with ASD, SCH, and those exhibiting subclinical traits to investigate the associations between mentalizing, attachment, and perceived social support during adolescence across the autistic and schizotypy spectrum.

Results
It was revealed that both autistic and schizotypal traits have comparable effects on insecure adult attachment, primarily through challenges in mentalizing. The impact of mentalizing deficits on adult attachment slightly varies between autistic and schizotypal traits. Conversely, perceived social support during adolescence relates to improved mentalizing and secure adult attachment as a protective factor during development.

Conclusions
These outcomes highlight the significance of supportive therapeutic relationships and community care while suggesting directions for further research and collaborative treatments addressing ASD and SCH, considering the differential impact of mentalizing on adult attachment.