bluuebunny/crossref_metadata_2025_split huggingface dataset:
MONARCH 3: Abemaciclib As Initial Therapy for Advanced Breast Cancer
Authors: Goetz Matthew P. , Toi Masakazu , Campone Mario , Sohn Joohyuk , Paluch-Shimon Shani , Huober Jens , Park In Hae , Trédan Olivier , Chen Shin-Cheh , Manso Luis , Freedman Orit C. , Garnica Jaliffe Georgina , Forrester Tammy , Frenzel Martin , Barriga Susana , Smith Ian C. , Bourayou Nawel , Di Leo Angelo 
Published: October 2017

Purpose Abemaciclib, a cyclin-dependent kinase 4 and 6 inhibitor, demonstrated efficacy as monotherapy and in combination with fulvestrant in women with hormone receptor (HR)–positive, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer previously treated with endocrine therapy. Methods MONARCH 3 is a double-blind, randomized phase III study of abemaciclib or placebo plus a nonsteroidal aromatase inhibitor in 493 postmenopausal women with HR-positive, HER2-negative advanced breast cancer who had no prior systemic therapy in the advanced setting. Patients received abemaciclib or placebo (150 mg twice daily continuous schedule) plus either 1 mg anastrozole or 2.5 mg letrozole, daily. The primary objective was investigator-assessed progression-free survival. Secondary objectives included response evaluation and safety. A planned interim analysis occurred after 189 events. Results Median progression-free survival was significantly prolonged in the abemaciclib arm (hazard ratio, 0.54; 95% CI, 0.41 to 0.72; P = .000021; median: not reached in the abemaciclib arm, 14.7 months in the placebo arm). In patients with measurable disease, the objective response rate was 59% in the abemaciclib arm and 44% in the placebo arm ( P = .004). In the abemaciclib arm, diarrhea was the most frequent adverse effect (81.3%) but was mainly grade 1 (44.6%). Comparing abemaciclib and placebo, the most frequent grade 3 or 4 adverse events were neutropenia (21.1% v 1.2%), diarrhea (9.5% v 1.2%), and leukopenia (7.6% v 0.6%). Conclusion Abemaciclib plus a nonsteroidal aromatase inhibitor was effective as initial therapy, significantly improving progression-free survival and objective response rate and demonstrating a tolerable safety profile in women with HR-positive, HER2-negative advanced breast cancer.
Surgical Treatment of Annuloaortic Ectasia – Replace or Repair?
Authors: Martino Andrea De , Re Federico , Blasi Stefania , Celiento Michele , Ravenni Giacomo , Pratali Stefano , Milano Aldo , Bortolotti Uberto 
Published: October 2017

Background:
Patients with annuloaortic ectasia may be surgically treated with modified Bentall or David I valve-sparing procedures. Here, we compared the long-term results of these procedures.

Methods:
A total of 181 patients with annuloaortic ectasia underwent modified Bentall (102 patients, Group 1) or David I (79 patients, Group 2) procedures from 1994 to 2015. Mean age was 62 ± 11 years in Group 1 and 64 ± 16 years in Group 2. Group 1 patients were in poorer health, with a lower ejection fraction and higher functional class.

Results:
Early mortality was 3% in Group 1 and 2.5% in Group 2. Patients undergoing a modified Bentall procedure had a higher incidence of thromboembolism and hemorrhage, whereas those undergoing a David I procedure had a higher incidence of endocarditis. Actuarial survival was 70 ± 6% at 15 years in Group 1 and 84 ± 7% at 10 years in Group 2. Actuarial freedom from reoperation was 97 ± 2% at 15 years in Group 1 and 84 ± 7% at 10 years in Group 2. In Group 2, freedom from procedure-related reoperations was 98 ± 2% at 10 years. At last follow-up, no cases of moderate or severe aortic regurgitation were observed.

Conclusions:
The modified Bentall and David I procedures showed excellent early and late results. The modified Bentall procedure with a mechanical conduit was associated with thromboembolic and hemorrhagic complications, whereas the David I procedure was associated with unexplained occurrences of endocarditis. Thus, the David I procedure appears to be safe, reproducible, and capable of achieving stable aortic valve repair and is therefore our currently preferred solution for patients with annuloaortic ectasia. However, the much shorter follow-up for David I patients limits the strength of our comparison between the two techniques.
Reporters in the age of data journalism
Authors: Veglis Andreas , Bratsas Charalampos 
Published: October 2017

Abstract
In the past, journalists were responsible for reporting the news. But today news stories disseminate as the incidents unfold, from multiple sources. Thus, gathering, filtering and visualizing events has a growing value. Huge amounts of data are available, but exploiting them is not an easy task. Data journalism can be defined as a journalism speciality in which numerical data are used in the production and distribution of information. This article investigates the necessary skills that journalists must have in order to cope with data journalism. More precisely, it defines data journalism, and discusses journalists’ Information and Communication Technology (ICT) skills, as well as the necessary skills for supporting data journalism. Special attention is given to Web 3.0 and open data that can play an important role in data journalism. A survey conducted among professional journalists in Greece concerning data journalism is also presented and discussed.
Applied diversity: A normative approach to improving news representations of ethno-cultural minorities based on the Canadian experience
Authors: Clark Brad 
Published: October 2017

Abstract
Western news organizations have long been accused of either ignoring or misrepresenting ethnic minorities in the media discourse. Proposals for reform have often been tied to hiring ethnically diverse journalists and to broad cultural awareness initiatives. Despite several decades of such efforts, study after study shows ethnic minorities are all too often under- and misrepresented in the news discourse. In Canada, where high rates of immigration and a burgeoning indigenous population are creating unprecedented demographic diversity, news media still struggle to produce consistently inclusive and equitable coverage. This article draws on research from Canada, as well as the United States and other western nations, identifying the major impediments to more accurate representations of ethnic minorities. It challenges reform initiatives of the past and details their failure to address the dominant bias inherent in mainstream news production routines. The author proposes explicit, new approaches to newsgathering practices targeting that dominant bias.
Situational ethics in photojournalism: Moving beyond doing good or doing right
Authors: Kim Yung Soo 
Published: October 2017

Abstract
Readers have different views on a photojournalist’s ethical situation when confronting the dilemma of whether to continue portraying a tragedy or intervening to help those in distress. Using an online experimental design with multiple stimuli, four situational characteristics were tested. Results showed that citizens (N=100) generally adopted a situational ethics rationale rather than an absolutist or utilitarian rationale. These findings substantiate an earlier study showing that readers do not universally condemn photojournalists who perform their professional duty instead of assisting persons in distress. However, readers would not object to photojournalists pursuing different actions according to specific situational circumstances.
Francophonie chinoise: Langues et identités en tension dans les œuvres de Dai Sijie, Gao Xingjian et Ying Chen
Authors: Laffitte Béatrice Bouvier 
Published: October 2017

Abstract
This article focuses on the complex, contradictory and changing relations that are established between the different languages of three multilingual authors from China: Ying Chen Dai Sijie and Gao Xingjian. After describing their particular linguistic situation (multilingualism in China and Chinese-French bilingualism in French-speaking areas), this article will attempt to situate them within the vast French-speaking literary area. Then, it will seek to elucidate how and to what extent they rely on the interaction of languages not only to create their own language but also to express the multiple modalities of their multilingual identity. This voluntary decentring of the initial language may reflect a search for both identity and a wish for linguistic emancipation.
Il sera question dans cet article des combinaisons complexes, mouvantes, contradictoires qui s’instaurent entre les langues du répertoire de trois écrivains plurilingues francophones originaires de Chine: Ying Chen, Dai Sijie, et Gao Xingjian. Après avoir décrit leur situation linguistique particulière (multilinguisme en Chine et bilinguisme français-chinois en milieu francophone), cette étude tentera de les situer au sein du grand ensemble à la fois un et composite que constitue l’espace francophone littéraire. Puis elle cherchera à élucider comment et dans quelles mesures ils s’appuient sur l’interaction des langues pour, non seulement créer un langage propre, mais aussi pour exprimer les multiples modalités de leur identité plurilingue. Ce positionnement volontairement excentré de la langue initiale pourrait correspondre à une recherche d’émancipation tant linguistique qu’identitaire.
Akeley inside the elephant: Trajectory of a taxidermic image
Authors: Behr Bernd 
Published: October 2017

Abstract
As a process distinct from its poured cousin, sprayed concrete involves using compressed air to propel cement with various chemical admixtures at a surface. Used in tunnelling for rock surface stabilization, and above ground for securing slopes and fabricating fake rockeries, its chimeric character ranges from the polished landscapes of skateparks and swimming pools to mimicking cast concrete in structural repair work. The origins of this industrial process lie with taxidermist Carl E. Akeley (1864–1926), who invented it during his pioneering work in the proto-photographic field of natural habitat dioramas at the Chicago Field Museum in 1907. Further cementing André Bazin’s notion of photography as embalmment, Akeley also invented a unique 35mm cine camera during his time at the American Museum of Natural History, New York. The essay explores this historical intersection between photography, taxidermy and architecture, and its wider implications for thinking through photography’s material contingency.
The illusion of inclusion: Agenda 21 and the commodification of Aboriginal culture in the Vancouver 2010 Olympic Games
Authors: Forsyth Janice 
Published: October 2017

Abstract
This article investigates the discourse about Aboriginal people benefitting from the 2010 Olympic Games and argues there was nothing fundamentally new about Aboriginal involvement in Vancouver, except for an unprecedented mobilization of Aboriginal bodies, land and insignia. In this regard, Aboriginal inclusion in 2010 was definitely different from past Games. There were more Aboriginal performers, artists and volunteers, more cultural imagery in strategic locations, and more indigenous merchandise for sale than ever before. Yet, in spite of their increased visibility, the power relations sustaining historic inequities between Olympic organizers and Aboriginal people remained largely unchanged. Indeed, a closer look at how Aboriginal people were involved in the Vancouver Games, the promises made to them, and the legacies that actually materialized, suggests the present day arrangement for Aboriginal people within the Olympic industry has actually worsened.
Resíduos de Serviços de Saúde: O Gerenciamento e a Legislação Pertinente
Authors: Ribeiro Edilton Juarez Matos , Ribeiro Mariana Emídio Oliveira , Lavor Anna Ariane Araújo de , Silva Antônio Carlos Alves da 
Published: October 2017

Os resíduos sólidos decorrentes das atividades humanas podem resultar em materiais com características de relativa inutilidade e potencial contaminante, cujo acúmulo facilita a formação de habitats propensos à proliferação de agentes microbiológicos nocivos à saúde humana e ao meio ambiente. Tais fatores dimanam, na realidade social atual, um grande desafio para os gestores, face os volumes crescentes desses materiais, que, se tratados e descartados inadequadamente, expõem a riscos de contaminação os seres humanos, os animais e o meio ambiente. No contexto dos resíduos sólidos inserem-se os resíduos de serviços de saúde, produzidos a partir das atividades de assistência à saúde humana e animal, com aspectos de virulência e contaminação bastante específicos, que, como tal, requerem tratamento diferenciado. O presente artigo objetivou apresentar aos profissionais da área de saúde, atuantes nos diversos segmentos, os conhecimentos sobre o gerenciamento dos resíduos de serviços de saúde nesses ambientes, consoante as informações técnicas, normativas e legais, emanadas dos órgãos que discorrem sobre esse tema. Utilizou-se o método analítico-descritivo, adotando como metodologia a pesquisa bibliográfica e documental em publicações de organismos da administração pública que normatizam as questões dos resíduos sólidos, normas técnicas de padrão internacional, dispositivos legais e resoluções internas dos órgãos ambientais e sanitários, das quais foram extraídas as análises e descrições cujo escopo é levar aos profissionais de saúde as informações sobre o correto gerenciamento dos resíduos de serviços de saúde, visando a preservação da saúde humana, do meio ambiente e dos recursos naturais.
Effects of alpha lipoic acid on acrylamide-induced hepatotoxicity in rats
Authors: Al-Qahtani F. A. , Arafah M. , Sharma B. , Siddiqi N. J. 
Published: October 2017

Acrylamide (ACR) is a neurotoxicant, reproductive toxicant, and carcinogen in animal species. It is used in many industries and has been found to form naturally in foods cooked at high temperatures. Alpha-lipoic acid (ALA) is a naturally occurring antioxidant whose therapeutic effect has been related to its antioxidant activity. This study was carried out to study the protective effect of alpha lipoic acid on acrylamide induced perturbations in rat liver. Four groups of rats were studied viz., control rats, acrylamide treated rats, alpha lipoic acid treated rats, and alpha lipoic acid plus acrylamide treated rats. ACR and ALA treatment alone and together caused a signifi­cant increase in hepatic reduced glutathione content while a decrease in hepatic ascorbic content was observed when compared to control group. ALA pretreatment of acrylamide exposed rats caused no a signifi­cant alteration in superoxide dismutase activity but resulted in a tendency towards restoration of glutathione peroxidase and catalase activity to near normal levels. Gel electrophoresis showed fragmentation of DNA in the treated groups. The dose of ALA used in the present study afforded partial restoration of oxidative indices altered by ACR in rat liver.
Effect of Microbial inoculation in combating the aluminium toxicity effect on growth of Zea mays
Authors: Arora P. , Singh G. , Tiwari A. 
Published: October 2017

The present study is aimed at improving the aluminium tolerance in maize crop employing the potential of microbial inoculants in conferring resistance to these toxicities via production of certain chelating compounds like siderophores, exopolysachharides and organic acids. Acid soils have now-a-days become one of the key factors for limiting growth of many agriculturally important crops. Aluminium is one of the major elements present in acid soils and is mainly responsible for toxicity in the soil. This aluminium is rapidly soluble in soil water and hence absorbed by plant roots under conditions where soil pH is below 5. This toxicity leads to severe root growth inhibition, thereby limiting the production of maize crops. It was observed that use of microbial inoculums can be helpful in elimination of these toxic compounds and prevent the inhibition of root growth . It was found that the soils contaminated with aluminium toxicity decreased the root length of maize plant significantly by 65% but Bacillus and Burkholderia inoculation increased this root length significantly by 1.4- folds and 2- folds respectively thereby combating the effect of aluminium toxicity. Aluminium concentration was found maximum in roots of plants which were grown under aluminium stress condition. But this aluminium accumulation decreased Ì´ 2-folds when Burkholderia was used as seed inoculants under aluminium stress conditions. Also, at 60mM aluminium accumulation, phosphorus solubilisation in roots was found to be increased upto 30% on Burkholderia inoculation. However, Bacillus inoculation didn't show any significant difference in either of the case. Thus, the inoculation of seeds with Burkholderia isolates could prove to be a boon in sequestering aluminium toxicity in Zea mays.
The Rise of the Khalwatiyah Sammān Sufi Order in South Sulawesi: Encountering the Local, Escaping the Global
Authors: Ubaedillah Achmad 
Published: October 2017

The rise of the Khalwatīyah Sammān Sufi Order (tarekat) in South Sulawesi in the second half of the nineteen century should not be seen as just another local religious phenomenon. The rapid growth of its reputation among commoners occurred in conjunction with the influence of global Islam brought to the area in the form of Wahabism from the Haramayn (Mecca and Medina), the center of Islam, and the local political consequences of the Bongaya Treaty between the ruler of Gowa and the Dutch in 1667. The political and social grievances the Treaty caused on the one hand and the religious elitism of formal religious leaders (parewa sarak) on the other also contributed to the impact the order was to have. The commoners widely accepted the order because of its uncomplicated way of the performance of its ritual (dhikr), while the patronage of its leaders with the royal members offered local power holders added to the order’s popularity among the elites.DOI: 10.15408/sdi.v24i2.4186
‘Rumi’ Networks of al-Sinkīlī: A Biography of Bāba Dāwud
Authors: Özay Mehmet 
Published: October 2017

This paper introduces Shaykh Dāwud ibn Ismā‘īl ibn Musṭafá Rūmī (also known as Bāba Dāwud or Musṭafá al-Rūmī) who was an Islamic scholar believed to have lived in Aceh sometime between 1650 and 1750 to the larger Muslim world. Shaykh Dāwud ibn Ismā‘īl ibn Musṭafá Rūmī is important for three reasons: (a) he lived during the time of the Sultanate of Aceh Darussalam (16th – 17th centuries) and he was the leading student and religious caliph of ‘Abd al-Ra’ūf al-Sinkīlī (Teungku Syiah Kuala), the well-known Acehnese religious scholar; (b) his Risālat masā’il al-muhtadī li ikhwān al-muhtadī has been taught at Islamic institutions in Aceh and all around the Malay world; and (c) no scholarly works have yet been written about him, despite the striking fact that he and Teungku Syiah Kuala co-founded the Dayah Manyang Leupue educational institution, to which he subsequently remained affiliated.DOI: 10.15408/sdi.v24i2.4441
Exploring Islamic School Leadership in a Challenging Southern Thailand Context
Authors: Raihani Raihani 
Published: October 2017

This study explores leadership practices in different Islamic schools in Southern Thailand, an area where already for decades an ethno-political conflict has been ongoing between Malay Muslims and the Thai Buddhist government. Using a multiple-case study approach, this research selected three Islamic schools one each in the provinces of Pattani, Narathiwat and Yala selecting their principals, teachers, and students as informants. The findings suggest that the principals, in their planning activities, tend to think strategically for the benefit of their schools, their students, and the community at large, that they are willing to compromise with the government so long as not contradicting their religious beliefs and principles, and that they have a strong vision for the school improvement. Under difficult conditions, they always consider the need to establish immediate and more extensive cooperation with various stakeholders to help further improve the school conditions and their output.DOI: 10.15408/sdi.v24i2.4608
Membaca Populisme Islam Model Baru
Authors: Garadian Endi Aulia 
Published: October 2017

Vedi R. Hadiz, Islamic Populism in Indonesia and the Middle East. Cambridge: Cambridge University Press. x + 228pp.This book wants to illustrate the compatibility of democracy with Islam. Under certain circumstances, it could be happened when alliances of marginalized classes unite in one shade under the banner of Islam. Focussing on Muslims in Indonesia, Egypt, and Turkey, Vedi R. Hadiz tries to see the process of Islamic populism formulation. This book elaborates more deeply the relationship between democratization, socio-economic change and the unbearable desire of globalization that has an impact on the evolution of the Muslim community’s struggle on those countries. By emphasizing the economic-political and socio-historical perspectives, the important point to be conveyed by Vedi that the motivation of the group interests and the economic advantages, to some extent, can give birth to the political power of Islam in the midst of society, rather than the ideology and the teachings of religion itself. Hence, basically, there is nothing that distinguishes Islamic political phenomena from the general political phenomenon. Finally, this book is important to read by those who want to get the latest framework in explaining the current development of Islamic Populism.DOI: 10.15408/sdi.v24i2.5708
Evaluating the Impact of Implementing a Clinical Practice Guideline for Febrile Infants With Positive Respiratory Syncytial Virus or Enterovirus Testing
Authors: DePorre Adrienne , Williams David D. , Schuster Jennifer , Newland Jason , Bartlett Jacqueline , Selvarangan Rangaraj , Mann Keith , McCulloh Russell 
Published: October 2017

OBJECTIVES:
To evaluate clinical practice patterns and patient outcomes among febrile low-risk infants with respiratory syncytial virus (RSV) infection or enterovirus (EV) meningitis after implementing a clinical practice guideline (CPG) that provides recommendations for managing febrile infants with RSV infection and EV meningitis.

METHODS:
Our institution implemented a CPG for febrile infants, which gives explicit recommendations for managing both RSV-positive and EV-positive infants in 2011. We retrospectively analyzed medical records of febrile infants ≤60 days old from June 2008 to January 2013. Among 134 low-risk RSV-positive infants, we compared the proportion of infants who underwent lumbar puncture (LP), the proportion of infants who received antibiotics, antibiotic hours of therapy (HOT), and length of stay (LOS) pre- and post-CPG implementation. Among 274 low-risk infants with EV meningitis, we compared HOT and LOS pre- and post-CPG implementation.

RESULTS:
Among low-risk RSV-positive patients, the proportion of infants undergoing LP, the proportion of infants receiving antibiotics, HOT, and LOS were unchanged post-CPG. Among low-risk infants with EV meningitis, HOT (79 hours pre-CPG implementation versus 46 hours post-CPG implementation, P &lt; .001) and LOS (47 hours pre-CPG implementation versus 43 hours post-CPG implementation, P = .01) both decreased post-CPG.

CONCLUSIONS:
CPG implementation is associated with decreased antibiotic exposure and hospital LOS among low-risk infants with EV meningitis; however, there were no associated changes in the proportion of infants undergoing LP, antibiotic exposure, or LOS among low-risk infants with RSV. Further studies are needed to determine specific barriers and facilitators to effectively incorporate diagnostic viral testing into medical decision-making for these infants.
BERGSON EN MILLAS: CONTRAPESO Y CONTRAPUNTO (PARTE I)
Authors: Smith Frederic 
Published: October 2017

E tema flosófco. Constata un acuerdo de raíz espiritualista sobre el valor l presente artículo conFirma la presencia en jorge millas de asuntos y problemas propuestos por bergson. Consigna sus diferencias sobre la relación entre intuición e inteligencia, y sobre la posibilidad de un sistema filosófico. Contrasta un acuerdo de raíz espiritualista sobre el valor ético de la flosofía y su incompatibilidad con todo dogmatismo y reduccionismo.