bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acoustic Reflex Screening of Conductive Hearing Loss for Third Window Disorders
Authors: Hong Robert S. , Metz Christopher M. , Bojrab Dennis I. , Babu Seilesh C. , Zappia John , Sargent Eric W. , Chan Eleanor Y. , Naumann Ilka C. , LaRouere Michael J. 
Published: December 2015

ObjectiveThis study examines the effectiveness of acoustic reflexes in screening for third window disorders (eg, superior semicircular canal dehiscence) prior to middle ear exploration for conductive hearing loss.Study DesignCase series with chart review.SettingOutpatient tertiary otology center.Subjects and MethodsA review was performed of 212 ears with acoustic reflexes, performed as part of the evaluation of conductive hearing loss in patients without evidence of chronic otitis media. The etiology of hearing loss was determined from intraoperative findings and computed tomography imaging. The relationship between acoustic reflexes and conductive hearing loss etiology was assessed.ResultsEighty‐eight percent of ears (166 of 189) demonstrating absence of all acoustic reflexes had an ossicular etiology of conductive hearing loss. Fifty‐two percent of ears (12 of 23) with at least 1 detectable acoustic reflex had a nonossicular etiology. The positive and negative predictive values for an ossicular etiology were 89% and 57% when acoustic reflexes were used alone for screening, 89% and 39% when third window symptoms were used alone, and 94% and 71% when reflexes and symptoms were used together, respectively.ConclusionAcoustic reflex testing is an effective means of screening for third window disorders in patients with a conductive hearing loss. Questioning for third window symptoms should complement screening. The detection of even 1 acoustic reflex or third window symptom (regardless of reflex status) should prompt further workup prior to middle ear exploration.
Giant Centrifugal and Necrotizing Cutaneous Metastases of Melanoma
Authors: di Meo Nicola , Nan Katiuscia , Vichi Silvia , Gatti Alessandro , Trevisan Giusto 
Published: December 2015

Background: Melanoma is a neoplasm derived from melanocytes of the skin and other sites. In the natural history of melanoma, cutaneous metastases occur relatively frequently and can arise in early or late stages of the disease. Objective and Methods: Melanoma skin metastases have a variable appearance. Several clinical appearances are described in the literature. Results and Conclusion: We describe an unusual clinical pattern of cutaneous melanoma metastasis, defined as giant, centrifugal, and necrotizing, and we provide a brief review of the literature.
A first-in-human phase 1 study of ACE910, a novel factor VIII–mimetic bispecific antibody, in healthy subjects
Authors: Uchida Naoki , Sambe Takehiko , Yoneyama Koichiro , Fukazawa Naoki , Kawanishi Takehiko , Kobayashi Shinichi , Shima Midori 
Published: December 2015

Key Points
Single subcutaneous dosing of ACE910 has a linear PK profile, a half-life of 4 to 5 weeks, and FVIII-mimetic procoagulant activity in humans. ACE910 at doses up to 1 mg/kg is well tolerated and has no notable adverse hypercoagulable effect in healthy Japanese and white adults.
Transfusion of fresher vs older red blood cells in hospitalized patients: a systematic review and meta-analysis
Authors: Alexander Paul E. , Barty Rebecca , Fei Yutong , Vandvik Per Olav , Pai Menaka , Siemieniuk Reed A. C. , Heddle Nancy M. , Blumberg Neil , McLeod Shelley L. , Liu Jianping , Eikelboom John W. , Guyatt Gordon H. 
Published: December 2015

AbstractThe impact of transfusing fresher vs older red blood cells (RBCs) on patient-important outcomes remains controversial. Two recently published large trials have provided new evidence. We summarized results of randomized trials evaluating the impact of the age of transfused RBCs. We searched MEDLINE, EMBASE, CINAHL, the Cochrane Database for Systematic Reviews, and Cochrane CENTRAL for randomized controlled trials enrolling patients who were transfused fresher vs older RBCs and reported outcomes of death, adverse events, and infection. Independently and in duplicate, reviewers determined eligibility, risk of bias, and abstracted data. We conducted random effects meta-analyses and rated certainty (quality or confidence) of evidence using the GRADE approach. Of 12 trials that enrolled 5229 participants, 6 compared fresher RBCs with older RBCs and 6 compared fresher RBCs with current standard practice. There was little or no impact of fresher vs older RBCs on mortality (relative risk [RR], 1.04; 95% confidence interval [CI], 0.94-1.14; P = .45; I2 = 0%, moderate certainty evidence) or on adverse events (RR, 1.02; 95% CI, 0.91-1.14; P = .74; I2 = 0%, low certainty evidence). Fresher RBCs appeared to increase the risk of nosocomial infection (RR, 1.09; 95% CI, 1.00-1.18; P = .04; I2 = 0%, risk difference 4.3%, low certainty evidence). Current evidence provides moderate certainty that use of fresher RBCs does not influence mortality, and low certainty that it does not influence adverse events but could possibly increase infection rates. The existing evidence provides no support for changing practices toward fresher RBC transfusion.
Timing of tracheotomy in ICU patients: a systematic review of randomized controlled trials
Authors: Hosokawa Koji , Nishimura Masaji , Egi Moritoki , Vincent Jean-Louis 
Published: December 2015

Abstract
Introduction
The optimal timing of tracheotomy in critically ill patients remains a topic of debate. We performed a systematic review to clarify the potential benefits of early versus late tracheotomy.

Methods
We searched PubMed and CENTRAL for randomized controlled trials that compared outcomes in patients managed with early and late tracheotomy. A random-effects meta-analysis, combining data from three a priori-defined categories of timing of tracheotomy (within 4 versus after 10 days, within 4 versus after 5 days, within 10 versus after 10 days), was performed to estimate the weighted mean difference (WMD) or odds ratio (OR).

Results
Of the 142 studies identified in the search, 12, including a total of 2,689 patients, met the inclusion criteria. The tracheotomy rate was significantly higher with early than with late tracheotomy (87 % versus 53 %, OR 16.1 (5.7-45.7); p <0.01). Early tracheotomy was associated with more ventilator-free days (WMD 2.12 (0.94, 3.30), p <0.01), a shorter ICU stay (WMD -5.14 (-9.99, -0.28), p = 0.04), a shorter duration of sedation (WMD -5.07 (-10.03, -0.10), p <0.05) and reduced long-term mortality (OR 0.83 (0.69-0.99), p = 0.04) than late tracheotomy.

Conclusions
This updated meta-analysis reveals that early tracheotomy is associated with higher tracheotomy rates and better outcomes, including more ventilator-free days, shorter ICU stays, less sedation, and reduced long-term mortality, compared to late tracheotomy.
Citrate anticoagulation for CRRT: don’t always trust the postfilter iCa results!
Authors: Oudemans-van Straaten Heleen M. , Ostermann Marlies 
Published: December 2015

AbstractCitrate has been recommended as the first-line anticoagulant for continuous renal replacement therapy (CRRT) in critically ill patients. Compared with heparin, citrate anticoagulation is safer and more efficacious. Citrate inhibits the coagulation cascade by lowering the ionized calcium (iCa) concentration in the filter. Monitoring of systemic iCa concentrations is inherent to the protocol, and monitoring of postfilter iCa is recommended to adjust citrate flow and optimize anticoagulation. While systemic iCa targets are in the physiological range, postfilter iCa concentrations are targeted between 0.20 and 0.35 mmol/l. In a previous issue of Critical Care, Schwarzer et al. compared systemic and postfilter iCa measurements of patients receiving citrate-based CRRT between six devices. They highlight the unreliability of iCa concentrations in the postfilter range, because the instruments cannot be validated in the low iCa range. The maximum mean difference between two instruments was as high as 0.33 mmol/l (range 0.21–0.50 mmol/l). The authors call for dialysis companies to revise their protocols. However, the first implication of their study is that the accuracy of blood gas analyzers to measure iCa in the low range needs to improve; and, secondly, clinicians using citrate anticoagulation need to be aware that the postfilter iCa result may be falsely high or low. This is particularly relevant when frequent premature filter clotting is observed despite postfilter iCa results in the seemingly target range. In these situations, citrate flow can be safely increased up to 4 mmol/l blood flow under monitoring of signs of citrate accumulation.
Incidence of cutaneous malignant melanoma by socioeconomic status in Canada: 1992–2006
Authors: Johnson-Obaseki Stephanie E. , Labajian Varant , Corsten Martin J. , McDonald James T. 
Published: December 2015

Background There are no nationwide studies documenting changes in cutaneous malignant melanoma incidence or association of incidence with socioeconomic status (SES) in Canada. We sought to determine whether melanoma incidence increased from 1992 to 2006 and if there was an association between SES and melanoma incidence. Additionally, we studied whether there was a correlation between province of residence and melanoma incidence. Methods Cases from the Canadian Cancer Registry were reviewed. Demographic and socioeconomic information were extracted from the Canadian Census of Population data. Cases were linked to income quintiles by postal code. A negative binomial regression was performed to identify relationships among these variables. Results Overall incidence of melanoma in Canada increased by 67 % from 1992 to 2006 ( p < 0.0001). The increase in incidence was greater for melanoma in situ compared with invasive melanoma (136 % versus 52 % [ p < 0.0001]). Incidence was positively correlated with higher income quintiles; the incidence rates among patients in the lowest income quintiles were 67 % of that for the highest income quintiles ( p < 0.0001). Discussion A wide variety of explanations have been postulated for an increased incidence in melanoma among persons of higher SES, including access to and awareness of screening, more access to vacations in sunny climates, and increased leisure time. Variations in incidence of melanoma by urban vs. rural location and province may indicate differences in access to dermatologists across Canada. Conclusions Melanoma incidence is increasing in Canada and is higher among people in high SES groups. This rise is likely due to a combination of factors including a true rise in incidence due to increases in sun exposure, and also an increased detection rate, particularly in those who are more aware of the disease and have access to resources for detection.
Lapatinib in Combination With Capecitabine Plus Oxaliplatin in Human Epidermal Growth Factor Receptor 2–Positive Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma: TRIO-013/LOGiC—A Randomized Phase III Trial
Authors: Hecht J. Randolph , Bang Yung-Jue , Qin Shukui K. , Chung Hyun C. , Xu Jianming M. , Park Joon O. , Jeziorski Krzysztof , Shparyk Yaroslav , Hoff Paulo M. , Sobrero Alberto , Salman Pamela , Li Jin , Protsenko Svetlana A. , Wainberg Zev A. , Buyse Marc , Afenjar Karen , Houé Vincent , Garcia Agathe , Kaneko Tomomi , Huang Yingjie , Khan-Wasti Saba , Santillana Sergio , Press Michael F. , Slamon Dennis 
Published: December 2015

Purpose To evaluate the efficacy of adding lapatinib to capecitabine and oxaliplatin (CapeOx) in patients with previously untreated human epidermal growth factor receptor 2 (HER2) –amplified advanced gastroesophageal adenocarcinoma. Patients and Methods Patients with HER2-positive advanced gastroesophageal adenocarcinoma were randomly assigned at a one-to-one ratio to CapeOx plus lapatinib 1,250 mg or placebo daily. Primary end point was overall survival (OS) in patients with centrally confirmed HER2 amplification in the primary efficacy population. Results A total of 545 patients were randomly assigned, and 487 patients comprised the primary efficacy population. Median OS in the lapatinib and placebo arms was 12.2 (95% CI, 10.6 to 14.2) and 10.5 months (95% CI, 9.0 to 11.3), respectively, which was not significantly different (hazard ratio, 0.91; 95% CI, 0.73 to 1.12). Median progression-free survival in the lapatinib and placebo arms was 6.0 (95% CI, 5.6 to 7.0) and 5.4 months (95% CI, 4.4 to 5.7), respectively (hazard ratio, 0.82; 95% CI, 0.68 to 1.00; P = .0381). Response rate was significantly higher in the lapatinib arm: 53% (95% CI, 46.4 to 58.8) compared with 39% (95% CI, 32.9 to 45.3) in the placebo arm (P = .0031). Preplanned exploratory subgroup analyses showed OS in the lapatinib arm was prolonged in Asian and younger patients. No correlation was observed between HER2 immunohistochemistry status and survival. There were increased toxicities in the lapatinib arm, particularly diarrhea. Conclusion Addition of lapatinib to CapeOx did not increase OS in patients with HER2-amplified gastroesophageal adenocarcinoma. There were clear differences in the effect of lapatinib depending on region and age. Future studies could examine this correlation.
Complete Surgical Excision Is Essential for the Management of Patients With Breast Implant–Associated Anaplastic Large-Cell Lymphoma
Authors: Clemens Mark W. , Medeiros L. Jeffrey , Butler Charles E. , Hunt Kelly K. , Fanale Michelle A. , Horwitz Steven , Weisenburger Dennis D. , Liu Jun , Morgan Elizabeth A. , Kanagal-Shamanna Rashmi , Parkash Vinita , Ning Jing , Sohani Aliyah R. , Ferry Judith A. , Mehta-Shah Neha , Dogan Ahmed , Liu Hui , Thormann Nora , Di Napoli Arianna , Lade Stephen , Piccolini Jorge , Reyes Ruben , Williams Travis , McCarthy Colleen M. , Hanson Summer E. , Nastoupil Loretta J. , Gaur Rakesh , Oki Yasuhiro , Young Ken H. , Miranda Roberto N. 
Published: December 2015

Purpose Breast implant–associated anaplastic large-cell lymphoma (BI-ALCL) is a rare type of T-cell lymphoma that arises around breast implants. The optimal management of this disease has not been established. The goal of this study is to evaluate the efficacy of different therapies used in patients with BI-ALCL to determine an optimal treatment approach. Patients and Methods In this study, we applied strict criteria to pathologic findings, assessed therapies used, and conducted a clinical follow-up of 87 patients with BI-ALCL, including 50 previously reported in the literature and 37 unreported. A Prentice, Williams, and Peterson model was used to assess the rate of events for each therapeutic intervention. Results The median and mean follow-up times were 45 and 30 months, respectively (range, 3 to 217 months). The median overall survival (OS) time after diagnosis of BI-ALCL was 13 years, and the OS rate was 93% and 89% at 3 and 5 years, respectively. Patients with lymphoma confined by the fibrous capsule surrounding the implant had better event-free survival (EFS) and OS than did patients with lymphoma that had spread beyond the capsule (P = .03). Patients who underwent a complete surgical excision that consisted of total capsulectomy with breast implant removal had better OS (P = .022) and EFS (P = .014) than did patients who received partial capsulectomy, systemic chemotherapy, or radiation therapy. Conclusion Surgical management with complete surgical excision is essential to achieve optimal EFS in patients with BI-ALCL.
Media, ideological hegemony and popular music: Golden microphone song contest<p>Medya, ideolojik hegemonya ve popüler müzik: Altın mikrofon şarkı yarışması
Authors: Ergun Levent 
Published: December 2015

<p>This article focuses on "Golden Microphone Award" song contest which has been organized under the sponsorship of Hürriyet Daily News between the years of 1965-68. Between the different forms of popular culture/music and mass media, there is a characteristically symbiotic relationship in which one almost can not survive in the absence of the other. Golden Microphone song contest, organized under the sponsorship of the mass media institution, Hürriyet Daily News, requires an evaluation in a scope that exceeds this symbiotic relationship. Because the role that Hürriyet plays in the circulation and the support of the dominant ideological definitions and representations is more important here. If we consider Golden Microphone contest as a moment,we can say that: there is a dynamic arena for the media, official ideology, musicians and audience in which both the elements of resistance and consent, the issues of the past and the future; hence overlapping and conflicting elements are available. In this framework, this research tries to analyse the dynamics of this specific moment of Turkish popular music history by using the theoretical status of media, sponsorship, ideology and hegemony concepts. </p><p> </p><p><strong>Özet</strong></p><p>Bu makale, Hürriyet Gazetesi’nin sponsorluğunda 1965-68 yılları arasında düzenlenen “Altın Mikrofon Armağanı” adlı şarkı yarışması üzerine odaklanır. Popüler kültürün/müziğin farklı formları ile kitle iletişim araçları arasında, diğeri olmadan birisinin hayatını neredeyse sürdüremez olduğu karakteristik bir simbiyotik ilişki vardır. Bir kitle medyası olarak Hürriyet Gazetesinin sponsorluğunda düzenlenen “Altın Mikrofon” şarkı yarışması, bu simbiyotik ilişkiyi aşan bir çerçeve içinde değerlendirmeyi de gerektirmektedir. Çünkü Hürriyet’in egemen ideolojik tanımlar ve temsillerin dolaşımı ve pekiştirilmesinde oynadığı rol, burada çok daha önemlidir. Altın Mikrofon yarışmasını bir uğrak (moment) olarak ele alırsak şunu söyleyebiliriz: bu uğrakta gerek medya, gerek resmi ideoloji, gerekse müzisyenler ve izlerkitle için; hem direniş hem kabullenme ögeleri, hem geçmişin ve geleceğin unsurları, dolayısıyla hem birbiriyle örtüşen hem de çatışan ögelerin olduğu dinamik bir mücadele alanı bulunmaktadır. Bu çerçevede çalışma; medya, sponsorluk, ideoloji ve hegemonya kavramlarının teorik statüsünden yararlanarak, Türk popüler müzik tarihinin bu özgül uğrağını biçimlendiren dinamikleri analiz etme girişimidir.</p>
Dynamic Libraries: Access, Development and Transformation
Authors: Altenhöner Reinhard , Gömpel Renate , Junger Ulrike , Meyer-Heß Anke , Solberg Susann , Svensson Lars G. 
Published: December 2015

Zusammenfassung:
Vom 15. bis 21. August 2015 hat in Kapstadt, Südafrika, der Weltkongress Bibliothek und Information, die 81. IFLA-Generalkonferenz stattgefunden. In diesem Beitrag berichten Kolleginnen und Kollegen der Deutschen Nationalbibliothek über die Veranstaltungen der Sektionen Bestandserhaltung, Bibliografie, Katalogisierung, Klassifikation und Indexierung, Informationstechnologie und Nationalbibliotheken sowie der Konferenz der Direktoren der Nationalbibliotheken.
Kostenmodelle in der digitalen Bestandserhaltung
Authors: Schmitt Karlheinz 
Published: December 2015

Zusammenfassung:
Dieser Beitrag behandelt die Frage, wie ein individuelles Kostenmodell für die digitale Langzeitarchivierung aufgestellt werden könnte. Mit einem Blick auf national und international existierende Ansätze und Aktivitäten in diesem Bereich werden einige notwendige Entscheidungen, die stets getroffen werden müssen, thematisiert. Hierdurch soll den Lesern eine mögliche Herangehensweise zur Erstellung eines auf die eigene Organisation angepassten Kostenmodells für die digitale Bestandserhaltung vorgeschlagen werden.
Workflow zur Identifizierung von Publikationen für die Zweitveröffentlichung
Authors: Thomas Linda , Stadler Heike 
Published: December 2015

Zusammenfassung:
Verfügbare Allianz- und Nationallizenzen können eine Open-Access-Komponente beinhalten. Diese räumen den autorisierten Autoren oder Einrichtungen bestimmte Open-Access-Rechte zur Zweitveröffentlichung ein. Vorhandene Lizenzrechte zur Realisierung des Grünen Weges können somit zukünftig verstärkt genutzt werden. Dabei kann die Bibliothek eine aktive Rolle einnehmen. Präsentiert wird ein Workflow, der sich an der Checkliste für Repository-Manager orientiert. Sieben herausgearbeitete Schritte werden genannt und näher erläutert. An Beispielen wurde der Workflow getestet. Die Ergebnisse werden ebenfalls vorgestellt. Die Erweiterung des Workflows zur Identifizierung von Publikationen für die Zweitveröffentlichung lässt sich ggf. auch auf Creative-Commons-Lizenzen anwenden bzw. auf Zeitschriften, die keine Open-Access-Komponente haben.
Bücherspeicher, Infobroker, Solitäre?
Authors: Drechsel Kathrin 
Published: December 2015

Zusammenfassung:
Der Sachstand bei der Darstellung des Berufsbildes „wissenschaftlicher Bibliothekar“ wird zusammengefasst und die betreffende Berufsgruppe in den konkreten berufspraktischen Kontext eingeordnet. Die Schlüsselbegriffe „Bildung“, „Wissen“ und „Wissensgesellschaft“ werden in ihrer gesellschaftlichen Rolle geprüft und in Beziehung zu aktuellen Positionen und Entwicklungen im Bibliothekswesen gesetzt. Durch eine konstruktive Auseinandersetzung mit ihrem komplexen Umfeld müssen Bibliotheken Klarheit gewinnen, um ihre Zukunft zu gestalten. Entscheidend dabei ist die Definition der Aufgaben, aus denen sich dann Berufsbilder herleiten.
Anmerkungen zum Ankauf einer Handschrift und von alten Drucken aus dem Zisterzienserkloster Himmerod durch das Landesbibliothekszentrum Rheinland-Pfalz
Authors: Schlechter Armin 
Published: December 2015

Zusammenfassung:
Das Landesbibliothekszentrum Rheinland-Pfalz hat am 24. und 25. September 2015 eine Handschrift des 12. Jahrhunderts sowie verschiedene Drucke gekauft beziehungsweise ersteigert, die das Zisterzienserkloster Himmerod im Landkreis Bernkastel-Wittlich aus seiner Büchersammlung zum Verkauf gebracht hatte. Zuvor und danach wurden im Internet teils richtige, teils verzerrte Informationen zu diesen Vorgängen veröffentlicht, bei denen auch die beteiligten staatlichen Stellen angegriffen wurden. Dieser Beitrag stellt die Ereignisse aus der Sicht des Verfassers als Mitarbeiter des Landesbibliothekszentrums Rheinland-Pfalz dar.
Cretaceous-Paleogene Boundary Clays from Spainand New Zealand: Arsenic Anomalies
Authors: Premović Pavle I. 
Published: December 2015

Abstract
Remarkably high arsenic (As) contents havebeen reported in numerous Cretaceous-Paleogene boundary(KPB) clays worldwide including those from Spain (atCaravaca and Agost) and New (N.) Zealand (at WoodsideCreek). Two interpretations have been offered to explainthis anomaly. The first one suggests that this As was generatedby the combustion of fossil fuels (such as crude oil,coal or oil shales) near the Chicxulub impact site and thesecond interpretation proposes the post-impact combustionof the global biomass at the KPB. Both types of combustionwere presumably triggered by the Chicxulub impactor.This report shows that the estimated surface densitiesof As in Spain and N. Zealand strongly contradict thefossil fuel hydrocarbons/biomass hypotheses. In addition,we also show that previously reported global abundancesof As at KPB are greatly overestimated.The high abundances of iron (Fe) in the ejecta layers fromSpain and N. Zealand lead us to a working hypothesis thata major fraction of their anomalous As was adsorbed fromseawater by the Fe-oxides. These oxides were mainly derivedof Fe from the vaporized carbonaceous chondrite impactor.These were originally deposited on the local (topographicallyhigh) oxic soils in Spain and N. Zealand andthen laterally transported to the KPB sites by the impactinducedsurface waters.