bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid-core nanocapsules increase the oral efficacy of quercetin in cutaneous leishmaniasis
Authors: SOUSA-BATISTA A. J. , POLETTO F. S. , PHILIPON C. I. M. S. , GUTERRES S. S. , POHLMANN A. R. , ROSSI-BERGMANN B. 
Published: June 2017

SUMMARYNew oral treatments are needed for all forms of leishmaniasis. Here, the improved oral efficacy of quercetin (Qc) and its penta-acetylated derivative (PQc) was evaluated in cutaneous leishmaniasis after encapsulation in lipid-core nanocapsules (LNCs) of poly(ε-caprolactone). Leishmania amazonensis-infected BALB/c mice were given 51 daily oral doses of free drugs (16 mg kg−1) or LNC-loaded drugs (0·4 mg kg−1). While treatment with free Qc reduced the lesion sizes and parasite loads by 38 and 71%, respectively, LNC-Qc produced 64 and 91% reduction, respectively. The antileishmanial efficacy of PQc was similar but not as potently improved by encapsulation as Qc. None of the treatments increased aspartate aminotransferase, alanine aminotransferase or creatinine serum levels. These findings indicate that when encapsulated in LNC, Qc and, to a lesser extent, PQc can safely produce an enhanced antileishmanial effect even at a 40-fold lower dose, with implications for the development of a new oral drug for cutaneous leishmaniasis.
Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome
Authors: Hirschtritt M. E. , Darrow S. M. , Illmann C. , Osiecki L. , Grados M. , Sandor P. , Dion Y. , King R. A. , Pauls D. , Budman C. L. , Cath D. C. , Greenberg E. , Lyon G. J. , Yu D. , McGrath L. M. , McMahon W. M. , Lee P. C. , Delucchi K. L. , Scharf J. M. , Mathews C. A. 
Published: June 2017

BackgroundThe unique phenotypic and genetic aspects of obsessive-compulsive (OCD) and attention-deficit/hyperactivity disorder (ADHD) among individuals with Tourette syndrome (TS) are not well characterized. Here, we examine symptom patterns and heritability of OCD and ADHD in TS families.MethodOCD and ADHD symptom patterns were examined in TS patients and their family members (N= 3494) using exploratory factor analyses (EFA) for OCD and ADHD symptoms separately, followed by latent class analyses (LCA) of the resulting OCD and ADHD factor sum scores jointly; heritability and clinical relevance of the resulting factors and classes were assessed.ResultsEFA yielded a 2-factor model for ADHD and an 8-factor model for OCD. Both ADHD factors (inattentive and hyperactive/impulsive symptoms) were genetically related to TS, ADHD, and OCD. The doubts, contamination, need for sameness, and superstitions factors were genetically related to OCD, but not ADHD or TS; symmetry/exactness and fear-of-harm were associated with TS and OCD while hoarding was associated with ADHD and OCD. In contrast, aggressive urges were genetically associated with TS, OCD, and ADHD. LCA revealed a three-class solution: few OCD/ADHD symptoms (LC1), OCD & ADHD symptoms (LC2), and symmetry/exactness, hoarding, and ADHD symptoms (LC3). LC2 had the highest psychiatric comorbidity rates (⩾50% for all disorders).ConclusionsSymmetry/exactness, aggressive urges, fear-of-harm, and hoarding show complex genetic relationships with TS, OCD, and ADHD, and, rather than being specific subtypes of OCD, transcend traditional diagnostic boundaries, perhaps representing an underlying vulnerability (e.g. failure of top-down cognitive control) common to all three disorders.
Seabird breeding population size on the Antarctic Peninsula related to fisheries activities in non-breeding ranges off South America
Authors: Krüger Lucas , Paiva Vitor H. , Petry Maria V. , Ramos Jaime A. 
Published: June 2017

AbstractPopulation growth of the southern giant petrelMacronectes giganteusfrom South America has been linked with an increase in fishing activities. It was demonstrated recently that a population from Elephant Island, Antarctic Peninsula, largely overlaps its non-breeding distribution with zones of high fishing intensity off South America. This study investigated the assumption that the increase in this population since the 1980s is related to an increase in fisheries off South America. Our results show that the population size is proportional to the increase in demersal and squid fisheries. These fisheries produce a considerable amount of discards, which can be used by non-breeding southern giant petrels as a food source during unfavourable conditions in winter. This may enhance the adult survival rates with potential carry-over effects on population size. Our study shows that we need to further understand the effects of fishery discards/offal on scavenging seabirds of the Southern Ocean, and highlights the importance of understanding the carry-over effects of seabird–fisheries interactions during the non-breeding phase in population dynamics.
Evaluating the use of external beam radiation alone in the management of cervix cancer
Authors: Al-Hajri Thuraya , Isfahanian Naghmeh , Alyamani Najlaa , Atallah Soha , Choan E. , Le Tien , Samant Rajiv 
Published: June 2017

AbstractAimTo determine the outcome of patients with locally advanced cervix cancer treated with curative intent using external beam radiotherapy (EBRT), without brachytherapy.Materials and methodsA chart review was performed of all patients with cervix cancer who received EBRT alone at our centre from 2000 to 2010. Overall survival and local control were evaluated using Kaplan–Meier survival curves.ResultsIn total, 22 patients were identified. The median age and follow-up were 56 years and 65 months, respectively. The stage included IB to IVB. Main histology was squamous cell carcinoma (82%). Median tumour size was 5·5 cm. Majority treated with 3D conformal techniques and nine patients (41%) were treated with intensity-modulated radiation therapy (IMRT); 14 patients received doses of ≥65 Gy. Most patients (73%) received weekly concurrent cis-platinum. The major reason for not receiving brachytherapy was locally extensive tumour (59%). The 5-year relapse-free survival and overall survival rates were 57 and 50%, respectively. Seven patients (32%) had a component of loco-regional failure, mainly within the cervix. There was a better outcome among the nine patients treated with IMRT to a median dose of 66 Gy with a loco-regional control of 78%.ConclusionsPatients who cannot have brachytherapy may still achieve acceptable rates of loco-regional disease control if high radiation doses (>65 Gy) was delivered.
Cohort differences in exercise adherence among primary care patients referred for mental health versus physical health conditions
Authors: Tobi Patrick , Kemp Philip , Schmidt Elena 
Published: June 2017

Abstract

Aim
To compare the characteristics of mental health and physical health participants attending an exercise referral scheme (ERS) and investigate associations with their adherence to exercise.

Background
While people referred to an ERS with a mental health diagnosis have similar initial rates of uptake as physical health participants, they are more likely to drop out. Comparisons of the groups to understand their differences and how these might impact on their adherence have been limited by the typically low numbers of mental health referrals in many schemes.

Methods
Retrospective analysis of a participant cohort. Data were extracted on all participants enrolled over a 12- month period (n = 701) and included measurements at baseline, mid-point (13 weeks) and end of programme (20-26 weeks). Differences were explored between the mental health (n=141) and physical health (n=560) subcohorts, and between adherers and non-adherers in each group. Binomial logistic regression estimated the effect of group-level factors associated with adherence.

Findings
Mental health referrals were more likely to be younger, White and unemployed, and had a lower mean body mass index and lower proportion of participants with high blood pressure. They were also more likely to drop out. While occupation was associated with exercise adherence among the physical health group, no predictive factors were identified in the mental health group.

Conclusion
Participants referred for mental health disorders are more likely to drop out of exercise referral schemes than those with physical health problems. While no factors were found to be predictive of their exercise adherence, an understanding of their distinguishing characteristics and attendance behaviour can guide in making better referral decisions concerning them and planning more appropriately tailored support.
miRNA-200c-3p is crucial in acute respiratory distress syndrome
Authors: Liu Qiang , Du Jianchao , Yu Xuezhong , Xu Jun , Huang Fengming , Li Xiaoyun , Zhang Cong , Li Xiao , Chang Jiahui , Shang Daozhen , Zhao Yan , Tian Mingyao , Lu Huijun , Xu Jiantao , Li Chang , Zhu Huadong , Jin Ningyi , Jiang Chengyu 
Published: June 2017

AbstractInfluenza infection and pneumonia are known to cause much of their mortality by inducing acute respiratory distress syndrome (ARDS), which is the most severe form of acute lung injury (ALI). Angiotensin-converting enzyme 2 (ACE2), which is a negative regulator of angiotensin II in the renin–angiotensin system, has been reported to have a crucial role in ALI. Downregulation of ACE2 is always associated with the ALI or ARDS induced by avian influenza virus, severe acute respiratory syndrome-coronavirus, respiratory syncytial virus and sepsis. However, the molecular mechanism of the decreased expression of ACE2 in ALI is unclear. Here we show that avian influenza virus H5N1 induced the upregulation of miR-200c-3p, which was then demonstrated to target the 3′-untranslated region of ACE2. Then, we found that nonstructural protein 1 and viral RNA of H5N1 contributed to the induction of miR-200c-3p during viral infection. Additionally, the synthetic analog of viral double-stranded RNA (poly (I:C)), bacterial lipopolysaccharide and lipoteichoic acid can all markedly increase the expression of miR-200c-3p in a nuclear factor-κB-dependent manner. Furthermore, markedly elevated plasma levels of miR-200c-3p were observed in severe pneumonia patients. The inhibition of miR-200c-3p ameliorated the ALI induced by H5N1 virus infection in vivo, indicating a potential therapeutic target. Therefore, we identify a shared mechanism of viral and bacterial lung infection-induced ALI/ARDS via nuclear factor-κB-dependent upregulation of miR-200c-3p to reduce ACE2 levels, which leads increased angiotensin II levels and subsequently causes lung injury.
Atomic structure and domain wall pinning in samarium-cobalt-based permanent magnets
Authors: Duerrschnabel M. , Yi M. , Uestuener K. , Liesegang M. , Katter M. , Kleebe H.-J. , Xu B. , Gutfleisch O. , Molina-Luna L. 
Published: June 2017

AbstractA higher saturation magnetization obtained by an increased iron content is essential for yielding larger energy products in rare-earth Sm2Co17-type pinning-controlled permanent magnets. These are of importance for high-temperature industrial applications due to their intrinsic corrosion resistance and temperature stability. Here we present model magnets with an increased iron content based on a unique nanostructure and -chemical modification route using Fe, Cu, and Zr as dopants. The iron content controls the formation of a diamond-shaped cellular structure that dominates the density and strength of the domain wall pinning sites and thus the coercivity. Using ultra-high-resolution experimental and theoretical methods, we revealed the atomic structure of the single phases present and established a direct correlation to the macroscopic magnetic properties. With further development, this knowledge can be applied to produce samarium cobalt permanent magnets with improved magnetic performance.
Yeast Cip1 is activated by environmental stress to inhibit Cdk1–G1 cyclins via Mcm1 and Msn2/4
Authors: Chang Ya-Lan , Tseng Shun-Fu , Huang Yu-Ching , Shen Zih-Jie , Hsu Pang-Hung , Hsieh Meng-Hsun , Yang Chia-Wei , Tognetti Silvia , Canal Berta , Subirana Laia , Wang Chien-Wei , Chen Hsiao-Tan , Lin Chi-Ying , Posas Francesc , Teng Shu-Chun 
Published: June 2017

AbstractUpon environmental changes, proliferating cells delay cell cycle to prevent further damage accumulation. Yeast Cip1 is a Cdk1 and Cln2-associated protein. However, the function and regulation of Cip1 are still poorly understood. Here we report that Cip1 expression is co-regulated by the cell-cycle-mediated factor Mcm1 and the stress-mediated factors Msn2/4. Overexpression of Cip1 arrests cell cycle through inhibition of Cdk1–G1 cyclin complexes at G1 stage and the stress-activated protein kinase-dependent Cip1 T65, T69, and T73 phosphorylation may strengthen the Cip1and Cdk1–G1 cyclin interaction. Cip1 accumulation mainly targets Cdk1–Cln3 complex to prevent Whi5 phosphorylation and inhibit early G1 progression. Under osmotic stress, Cip1 expression triggers transient G1 delay which plays a functionally redundant role with another hyperosmolar activated CKI, Sic1. These findings indicate that Cip1 functions similarly to mammalian p21 as a stress-induced CDK inhibitor to decelerate cell cycle through G1 cyclins to cope with environmental stresses.
Data analytics using canonical correlation analysis and Monte Carlo simulation
Authors: Rickman Jeffrey M. , Wang Yan , Rollett Anthony D. , Harmer Martin P. , Compson Charles 
Published: June 2017

AbstractA canonical correlation analysis is a generic parametric model used in the statistical analysis of data involving interrelated or interdependent input and output variables. It is especially useful in data analytics as a dimensional reduction strategy that simplifies a complex, multidimensional parameter space by identifying a relatively few combinations of variables that are maximally correlated. One shortcoming of the canonical correlation analysis, however, is that it provides only a linear combination of variables that maximizes these correlations. With this in mind, we describe here a versatile, Monte-Carlo based methodology that is useful in identifying non-linear functions of the variables that lead to strong input/output correlations. We demonstrate that our approach leads to a substantial enhancement of correlations, as illustrated by two experimental applications of substantial interest to the materials science community, namely: (1) determining the interdependence of processing and microstructural variables associated with doped polycrystalline aluminas, and (2) relating microstructural decriptors to the electrical and optoelectronic properties of thin-film solar cells based on CuInSe2 absorbers. Finally, we describe how this approach facilitates experimental planning and process control.
Genetic association analysis of the RTK/ERK pathway with aggressive prostate cancer highlights the potential role of CCND2 in disease progression
Authors: Chen Yang , Zhang Qin , Wang Qiuyan , Li Jie , Sipeky Csilla , Xia Jihan , Gao Ping , Hu Yanling , Zhang Haiying , Yang Xiaobo , Chen Haitao , Jiang Yonghua , Yang Yuehong , Yao Ziting , Chen Yinchun , Gao Yong , Tan Aihua , Liao Ming , Schleutker Johanna , Xu Jianfeng , Sun Yinghao , Wei Gong-Hong , Mo Zengnan 
Published: June 2017

AbstractThe RTK/ERK signaling pathway has been implicated in prostate cancer progression. However, the genetic relevance of this pathway to aggressive prostate cancer at the SNP level remains undefined. Here we performed a SNP and gene-based association analysis of the RTK/ERK pathway with aggressive prostate cancer in a cohort comprising 956 aggressive and 347 non-aggressive cases. We identified several loci including rs3217869/CCND2 within the pathway shown to be significantly associated with aggressive prostate cancer. Our functional analysis revealed a statistically significant relationship between rs3217869 risk genotype and decreased CCND2 expression levels in a collection of 119 prostate cancer patient samples. Reduced expression of CCND2 promoted cell proliferation and its overexpression inhibited cell growth of prostate cancer. Strikingly, CCND2 downregulation was consistently observed in the advanced prostate cancer in 18 available clinical data sets with a total amount of 1,095 prostate samples. Furthermore, the lower expression levels of CCND2 markedly correlated with prostate tumor progression to high Gleason score and elevated PSA levels, and served as an independent predictor of biochemical relapse and overall survival in a large cohort of prostate cancer patients. Together, we have identified an association of genetic variants and genes in the RTK/ERK pathway with prostate cancer aggressiveness, and highlighted the potential importance of CCND2 in prostate cancer susceptibility and tumor progression to metastasis.
Identifying affective personality profiles: A latent profile analysis of the Affective Neuroscience Personality Scales
Authors: Orri Massimiliano , Pingault Jean-Baptiste , Rouquette Alexandra , Lalanne Christophe , Falissard Bruno , Herba Catherine , Côté Sylvana M. , Berthoz Sylvie 
Published: June 2017

AbstractBased on evolutionary theory, a recent model in affective neuroscience delineated six emotional brain systems at the core of human personality: SEEKING, CARING, PLAYFULNESS, FEAR, ANGER, SADNESS. The Affective Neuroscience Personality Scales (ANPS) assess their functioning. Using a person-centred approach of the ANPS, this study: (i) examined the existence of latent personality profiles, (ii) studied their gender invariance, (iii) assessed their longitudinal (4 years) stability, and (iv) explored how they relate to several intrapersonal, interpersonal, and emotion regulation skills. Latent Profile Analysis in 2 samples (Canadian, longitudinal, N = 520; French, cross-sectional, N = 830) found that, qualitatively, 3 profiles characterized both populations and genders, with one distinction for the second profile where the French women endorsed slightly higher and lower scores for, respectively, the negative and positive emotions. Whilst not being quantitatively similar across genders, the personality profiles remained consistent across time in the longitudinal sample. Associations between profiles and intrapersonal (e.g. depression), interpersonal (e.g. empathy), and emotion regulation skills measures (e.g. emotional intelligence) offered concurrent validity evidence. This person centred approach to ANPS offers a holistic and parsimonious way to study affective personality dimensions. It opens promising avenues for future studies on the predictive value of ANPS profiles, and for personality-targeted interventions.
Improving biodiversity assessment via unsupervised separation of biological sounds from long-duration recordings
Authors: Lin Tzu-Hao , Fang Shih-Hua , Tsao Yu 
Published: June 2017

AbstractInvestigating the dynamics of biodiversity via passive acoustic monitoring is a challenging task, owing to the difficulty of identifying different animal vocalizations. Several indices have been proposed to measure acoustic complexity and to predict biodiversity. Although these indices perform well under low-noise conditions, they may be biased when environmental and anthropogenic noises are involved. In this paper, we propose a periodicity coded non-negative matrix factorization (PC-NMF) for separating different sound sources from a spectrogram of long-term recordings. The PC-NMF first decomposes a spectrogram into two matrices: spectral basis matrix and encoding matrix. Next, on the basis of the periodicity of the encoding information, the spectral bases belonging to the same source are grouped together. Finally, distinct sources are reconstructed on the basis of the cluster of the basis matrix and the corresponding encoding information, and the noise components are then removed to facilitate more accurate monitoring of biological sounds. Our results show that the PC-NMF precisely enhances biological choruses, effectively suppressing environmental and anthropogenic noises in marine and terrestrial recordings without a need for training data. The results may improve behaviour assessment of calling animals and facilitate the investigation of the interactions between different sound sources within an ecosystem.
Response of Atlantic salmon Salmo salar to temperature and dissolved oxygen extremes established using animal-borne environmental sensors
Authors: Stehfest Kilian M. , Carter Chris G. , McAllister Jaime D. , Ross Jeff D. , Semmens Jayson M. 
Published: June 2017

AbstractUnderstanding how aquatic species respond to extremes of DO and temperature is crucial for determining how they will be affected by climate change, which is predicted to increasingly expose them to levels beyond their optima. In this study we used novel animal-borne DO, temperature and depth sensors to determine the effect of extremes of DO and temperature on the vertical habitat use of Atlantic salmon Salmo salar in aquaculture cages. Salmon showed a preference for temperatures around 16.5 to 17.5 °C, however, selection of preferred temperatures was trumped by active avoidance of low DO (<35% saturation) at the bottom of the cage. In addition to low DO, salmon also avoided warm surface waters (>20.1 °C), which led to a considerable contraction in the available vertical habitat. Despite their avoidance behavior, fish spent a large amount of time in waters with suboptimal DO (<60% saturation). These results show that vertical habitat contraction could likely be a significant consequence of climate change if the reduction in DO outpaces the increase in hypoxia tolerance through local adaptation. They furthermore highlight that site-specific environmental conditions and stock-specific tolerance thresholds may need to be considered when determining stocking densities.
Comparative transcriptome analysis on the synthesis pathway of honey bee (Apis mellifera) mandibular gland secretions
Authors: Wu YuQi , Zheng HuoQing , Corona Miguel , Pirk Christian , Meng Fei , Zheng YuFei , Hu FuLiang 
Published: June 2017

AbstractSecretions from mandibular glands (MGs) have important caste-specific functions that are associated with the social evolution of honey bees. To gain insights into the molecular architecture underlying these caste differences, we compared the gene expression patterns of MGs from queens, queenright workers (WQRs) and queenless workers (WQLs) using high-throughput RNA-sequencing technology. In total, we identified 46 candidate genes associated with caste-specific biosynthesis of fatty acid pheromones in the MG, including members of cytochrome P450 (CYP450) family and genes involved in fatty acid β-oxidation and ω-oxidation. For further identification of the CYP450s genes involved in the biosynthesis of MG secretions, we analyzed by means of qPCR, the expression levels of six of the CYP450 genes most abundantly expressed in the transcriptome analysis across different castes, ages, tasks and tissues. Our analysis revealed that CYP6AS8 and CYP6AS11, the most abundantly expressed CYP450 genes in worker and queen MGs, respectively, are selectively expressed in the MGs of workers and queens compared to other tissues. These results suggest that these genes might be responsible for the critical bifurcated hydroxylation process in the biosynthesis pathway. Our study contributes to the description of the molecular basis for the biosynthesis of fatty acid-derived pheromones in the MGs.