bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Plasminuria with Overhydration in Patients with CKD
Authors: Schork Anja , Woern Matthias , Kalbacher Hubert , Voelter Wolfgang , Nacken Regina , Bertog Marko , Haerteis Silke , Korbmacher Christoph , Heyne Nils , Peter Andreas , Häring Hans-Ulrich , Artunc Ferruh 
Published: March 2016

Background and objectives
Hypervolemia is a common feature of patients with CKD and associated with hypertension. Recent work has shown stimulation of sodium retention by urinary plasmin during nephrotic syndrome. However, it is unclear whether plasminuria plays a role in patients with stable CKD and non-nephrotic proteinuria.

Design, setting, participants, & measurements
In this cross-sectional study, we analyzed the fluid status of 171 patients with CKD consecutively presenting to our outpatient clinic from 2012 to 2013 using bioimpedance spectroscopy (Body Composition Monitor [BCM]; Fresenius Medical Care, Germany) and its associations to the urinary excretion of plasminogen and plasmin from a spot urine sample. Two–electrode voltage clamp measurements were performed in Xenopus laevis oocytes expressing human epithelial sodium channel to investigate whether plasmin in concentrations found in urine can activate the channel.

Results
Overhydration >5% and overhydration >10% of the extracellular volume were found in 29% and 17% of the patients, respectively, and overhydration was associated with edema, hypertension, higher stages of CKD, and proteinuria. Proteinuria was the strongest independent predictor for overhydration (+0.58 L/1.73 m2 per 10-fold increase; P<0.001). Urinary excretion of plasmin(ogen) quantified by ELISA correlated strongly with proteinuria (r=0.87) and overhydration (r=0.47). Using a chromogenic substrate, active plasmin was found in 44% of patients and correlated with proteinuria and overhydration. Estimated urinary plasmin concentrations were in a range sufficient to activate epithelial sodium channel currents in vitro. In multivariable analysis, urinary excretion of plasmin(ogen) was associated with overhydration similar to proteinuria.

Conclusions
Hypervolemia in patients with CKD is strongly associated with proteinuria, even in the non-nephrotic range. Protein-rich urine contains high amounts of plasminogen and active plasmin, rendering plasminuria as a possible link between proteinuria and hypervolemia.
Beyond Machine Dreams: Zen, Cyber-, and Transnational Feminisms in Ruth Ozeki's A Tale for the Time Being
Authors: Starr Marlo 
Published: March 2016

Abstract
In Ruth Ozeki's 2013 novel A Tale for the Time Being, sixteen-year-old Nao faces severe bullying and sexual violence at her new school in Japan. Seeking escape, she experiments with different identities, turning first to the Internet and then later to Zen Buddhist practices. These approaches appeal to her because they allow her to transcend the bounds of her physical body, but she soon finds these experiences limiting in other ways.
Intervening in discourses about the liberating potentials of cyber- and Buddhist feminisms, Ozeki's novel explores how experiences of disembodiment are empowering in some ways and inhibiting in others. This article argues that A Tale for the Time Being critiques philosophies that strive for social liberation by denying physicality and introduces a model of feminism that balances material and bodily experiences with ideas of equality that emerge from cyber-, Buddhist, and transnational feminist projects.
Higher Education Among Bedouin of the Negev: Tel Sheva as a Case Study
Authors: El-Meccawi Shaher , Degen A. Allan 
Published: March 2016

Abstract
A study on higher education was carried out in Tel Sheva during 2012-14. There were 7,223 residents above the age of eighteen of whom 433 residents ((229 males (52.9 per cent) : 204 females (47.1 per cent)) had post-secondary degrees or diplomas (past students) and 277 residents ((91 males (32.9 per cent) : 186 females (67.1 per cent)) were enrolled (present students) in institutes of higher education, giving a total of 710 students ((320 males (45 per cent) : 390 females (55 per cent)), or 9.8 per cent of those eligible. Of the 710 past and present total students, 61.8 per cent enrolled in education. Medicine and medicine-related studies ranked second at 15.8 per cent, engineering third at 13.4 per cent, law fourth at 3.9 per cent and psychology/sociology fifth at 2.1 per cent. A number of trends emerged when we compared past and present students. The percentage of females, of the total student body, rose from 47.1 per cent in the past to 67.1 per cent today, and the gap between genders seems to be widening. The percentage of students in education has remained relatively constant, 61.7 per cent in the past and 62.3 per cent today. However, the percentage of students in medicine and medicine-related studies has been increasing (11.1 per cent to 23.2 per cent), whereas the percentages of engineering (16.6 per cent to 8.3 per cent) and law (4.8 per cent to 2.5 per cent) students have been decreasing substantially. The percentage of females studying education is much higher than that of males while the reverse is true in medicine and engineering. More Bedouin are studying abroad today, in particular medicine and dentistry, and mostly in Romania and Moldova.
Role of Tibetan Women in Carbon Balance in the Alpine Grasslands of the Tibetan Plateau. A Review
Authors: Shang Zhanhuan , White Andrew , Degen A. Allan , Long Ruijun 
Published: March 2016

Abstract
Males and females often contribute differently to the ecosystem as a result of their different roles and labour responsibilities. This is especially true in remote areas like the Tibetan alpine grasslands, where women handle most household chores and agricultural labour. Within this framework, women are involved physically in carbon balance to a much greater extent than are men. The collection and use of livestock dung for fuel (dung-fuel) and the production of livestock commodities are two female activities that are extremely important in the carbon cycle in grassland ecosystems. More than ninety per cent of fuel in the alpine grassland areas in China comes from livestock dung, which is collected and burnt by women. In addition, animal carbon leaves the grassland ecosystems through the selling of milk products by women. The burning of dung reduces the use of fossil fuels and wood in alpine areas, but causes severe indoor air pollution in homes and greatly increases health risks, mainly among women. Women should receive more education on and made aware of these dangers. Because of their heavy work load and busy time schedule, however, Tibetan women have little time for other activities. Consequently, their education is at an extremely poor level and their health issues are often neglected. Steps should be taken to improve the status of women in the community, involve them more in decision-making, promote their education and health standards, and encourage more gender equality in agricultural labour tasks. These changes for women have been implemented in other pastoral societies and have proven to be successful.
Le développement urbain à Bavay à la lumière des recherches récentes.
Authors: Thollard Patrick 
Published: March 2016

De stadsontwikkeling van Bavay in het recent onderzoek.
Tradioneel neemt men aan dat de ontwikkeling van Bavay een groei in twee stadia was, met twee verschillende stratenpatronen ; het oudste rond het forum in het westen, het nieuwste als een uitbreiding naar het oosten. Een nieuw onderzoek van de gegevens waarop deze théorie steunde en récente ontdekkingen voeren naar een ander model. Van zijn stichting in de laatste twee decennia voor Chr. af had de stad het regelmatige stratenpatroon waarvan men vroeger dacht dat het het nieuwste was. In het midden van de eerste eeuw na Chr. werd dit plan gedeeltelijk verstoord door de inplanting van het forum. De topografische gegevens lieten niet toe dit monumentale bouwwerk perfekt in het oorspronkelijke plan in te passen ; zo was het nodig nieuwe straten aan te leggen en de wijken naast het forum aan te passen.
Recherches archéologiques à Bavay, XIV-XVII (Basilique civile, 1993-1994).
Authors: Hanoune Roger , Muller Arthur 
Published: March 2016

Les campagnes de fouille 1993 et 1994 dans la basilique civile ont été consacrées pour l'essentiel à l'étude de la façade occidentale du monument et de son articulation avec la place dallée du forum. A la suite de ces travaux la basilique est complètement dégagée des constructions postérieures (restes des fondations de la Chapelle du Collège des Oratoriens), à l'exception de l'emprise des rues actuelles.
La fouille en aire ouverte et les sondages ont permis d'étudier les traces d'occupation antérieures à l'édification de la basilique (par exemple l'extension probable d'une couche riche en fragments de moules à flans monétaires), et surtout l'ordonnance de la façade dans les différents états du monument : rectiligne avec sans doute un escalier sur toute la longueur entre les avant-corps dans le premier état ("basilique jaune"), puis articulée en saillants et rentrants avec des accès latéraux dans les derniers états ("basiliques rose et tricolore"). Des compléments de vérification ont porté sur la muraille du Bas-Empire et sur l'aile et la terrasse orientales de la basilique : ces derniers n'ont fait que confirmer les hypothèses émises précédemment sur le dispositif des "boutiques" ouvrant vers l'extérieur du monument dans le premier état et vers l'intérieur dans les états ultérieurs.
Recherches archéologiques à Bavay, XVIII (La céramique des périodes I, II et III de la Basilique civile de Bavay).
Authors: Geoffroy Jean-François 
Published: March 2016

Opgravingen in Bavay, XVIII (keramiek van de periode I, II, III van de burgelijke basiliek)
Dit artikel omvat de eerste resultaten van een studie over de tussen 1988 en 1993 aan het licht gebrachte overblijfselen van meubels. Het gaat slechts om een paar fragmenten. De synthese betreft alleen periode I (voor de bouw van de eerste basiliek), periode II (gele basiliek) en III (roze basiliek). Periode I : de fragmenten van italische sigillata, bekers met fijne wanden en gallo-belgische keramiekfragmenten laten een datering toe van de laatste twee decennia van de eerste eeuw voor Chr. tot het derde decennium van de eerste eeuw, zonder verdere bepaling van de terminus post quem. Période II : het lokale karakter overheerst hier, sigillata uit Zuid-Gallië werd ontdekt in de buurt van het noorderterras ontdekt in de aanaarding voor de gele basiliek (Drag. 15/17, Drag. 29 en wat Ritterling met stempel SENICIO FE) ;de terminus post quem kan bepaald worden in het derde kwart van de 1st. eeuw. Periode III :terminus post quem van het laatste decennium van de eerste eeuw tot begin tweede eeuw, maar het lokale karakter, het gebruik van dezelfde aanaardingen, het kleine aantal keramiekfragmenten en de frekwentie van gewoon gedraaid aardewerk maken dat het resultaat van dit onderzoek zeer voorlopig blijft.
Nécropole protohistorique et gallo-romaine à Izel-les- Equerchin.
Authors: Demolon Pierre , Compagnon Eric , Louis Etienne 
Published: March 2016

Proto-historical and Gallo-Roman Burying Site in Izel-les-Equerchin.
Thanks to the widening of the Al motorway, close to the Escrebieux valley, the proto-historical and Gallo-Roman occupation discovered under the High Speed Train track could be further spotted during the excavating work. A proto-historical circle, very ill preserved and a few Gallo Roman graves, form the major part of the structures identified. A few ditches structuring the landscape were also unearthead. The bad conditions in which the observation could be carried out limited the scientific conclusions these discoveries could lead to.
Méthode de diagnostic appliquée à Hénin-Beaumont (Pas-de-Calais).
Authors: Barbé Hervé , Barret Michel , Mangeon Guillaume 
Published: March 2016

Onderzoeksmethode gebruikt in Hénin-Beaumont (Pas-de-Calais).
Het onderzoek op het terrein van een bouwproject te Hénin-Beaumont, "Z.A.C. du Bord des Eaux" genaamd, bood de gelegenheid een onderzoeksmethode uit te werken aangepast aan factoren als oppervlakte (110 ha), période (4 maand), verschillende diepte van de overblijfselen. In het artikel worden de voordelen en de grenzen van deze mekanische prospektie besproken. Het was mogelijk via deze techniek een eerste overzicht te krijgen van het archeologisch potentieel van de Z.A.C. Een diachronische voorstelling van de resultaten en van enkele vondsten is daarvan het resultaat. Zo kon men een keuze maken, sommige zones verlaten, andere meer aandacht geven, rekening houdend met de mogelijke archeologische rijkdom.
ULTRA-NARROW NEGATIVE FLARE FRONT OBSERVED IN HELIUM-10830 Å USING THE 1.6 m NEW SOLAR TELESCOPE
Authors: Xu Yan , Cao Wenda , Ding Mingde , Kleint Lucia , Su Jiangtao , Liu Chang , Ji Haisheng , Chae Jongchul , Jing Ju , Cho Kyuhyoun , Cho Kyungsuk , Gary Dale , Wang Haimin 
Published: March 2016

ABSTRACT
Solar flares are sudden flashes of brightness on the Sun and are often associated with coronal mass ejections and solar energetic particles that have adverse effects on the near-Earth environment. By definition, flares are usually referred to as bright features resulting from excess emission. Using the newly commissioned 1.6 m New Solar Telescope at Big Bear Solar Observatory, we show a striking “negative” flare with a narrow but unambiguous “dark” moving front observed in He i 10830 Å, which is as narrow as 340 km and is associated with distinct spectral characteristics in Hα and Mg ii lines. Theoretically, such negative contrast in He i 10830 Å can be produced under special circumstances by nonthermal electron collisions or photoionization followed by recombination. Our discovery, made possible due to unprecedented spatial resolution, confirms the presence of the required plasma conditions and provides unique information in understanding the energy release and radiative transfer in astronomical objects.
WHITE DWARF MERGERS ON ADAPTIVE MESHES. I. METHODOLOGY AND CODE VERIFICATION
Authors: Katz Max P. , Zingale Michael , Calder Alan C. , Swesty F. Douglas , Almgren Ann S. , Zhang Weiqun 
Published: March 2016

ABSTRACT
The Type Ia supernova (SN Ia) progenitor problem is one of the most perplexing and exciting problems in astrophysics, requiring detailed numerical modeling to complement observations of these explosions. One possible progenitor that has merited recent theoretical attention is the white dwarf (WD) merger scenario, which has the potential to naturally explain many of the observed characteristics of SNe Ia. To date there have been relatively few self-consistent simulations of merging WD systems using mesh-based hydrodynamics. This is the first paper in a series describing simulations of these systems using a hydrodynamics code with adaptive mesh refinement. In this paper we describe our numerical methodology and discuss our implementation in the compressible hydrodynamics code CASTRO, which solves the Euler equations, and the Poisson equation for self-gravity, and couples the gravitational and rotation forces to the hydrodynamics. Standard techniques for coupling gravitation and rotation forces to the hydrodynamics do not adequately conserve the total energy of the system for our problem, but recent advances in the literature allow progress and we discuss our implementation here. We present a set of test problems demonstrating the extent to which our software sufficiently models a system where large amounts of mass are advected on the computational domain over long timescales. Future papers in this series will describe our treatment of the initial conditions of these systems and will examine the early phases of the merger to determine its viability for triggering a thermonuclear detonation.
JET SIGNATURES IN THE SPECTRA OF ACCRETING BLACK HOLES
Authors: Riordan Michael O’ , Pe’er Asaf , McKinney Jonathan C. 
Published: March 2016

ABSTRACT
Jets are observed as radio emission in active galactic nuclei and during the low/hard state in X-ray binaries (XRBs), but their contribution at higher frequencies has been uncertain. We study the dynamics of jets in XRBs using the general-relativistic magnetohydrodynamic code HARM. We calculate the high-energy spectra and variability properties using a general-relativistic radiative transport code based on grmonty. We find the following signatures of jet emission: (i) a significant γ-ray peak above ∼1022 Hz, (ii) a break in the optical/UV spectrum, with a change from

to

, followed by another break at higher frequencies where the spectrum roughly returns to

, and (iii) a pronounced synchrotron peak near or below ∼1014 Hz indicates that a significant fraction of any observed X-ray emission originates in the jet. We investigate the variability during a large-scale magnetic field inversion in which the Blandford–Znajek (BZ) jet is quenched and a new transient hot reconnecting plasmoid is launched by the reconnecting field. The ratio of the γ-rays to X-rays changes from

in the BZ jet to

during the launching of the transient plasmoid.
AN OVERMASSIVE DARK HALO AROUND AN ULTRA-DIFFUSE GALAXY IN THE VIRGO CLUSTER
Authors: Beasley Michael A. , Romanowsky Aaron J. , Pota Vincenzo , Navarro Ignacio Martin , Delgado David Martinez , Neyer Fabian , Deich Aaron L. 
Published: March 2016

ABSTRACT
Ultra-diffuse galaxies (UDGs) have the sizes of giants but the luminosities of dwarfs. A key to understanding their origins comes from their total masses, but their low surface brightnesses (

25.0) generally prohibit dynamical studies. Here, we report the first such measurements for a UDG (VCC 1287 in the Virgo cluster), based on its globular cluster system dynamics and size. From seven GCs we measure a mean systemic velocity v
sys =

km s−1, thereby confirming a Virgo cluster association. We measure a velocity dispersion of

km s−1 within 8.1 kpc, corresponding to an enclosed mass of (4.5 ± 2.8) × 109
M
⊙ and a g-band mass-to-light ratio of

within an effective radius. From the cumulative mass curve, along with the GC numbers, we estimate a virial mass of ∼8 × 1010
M
⊙, yielding a dark-to-stellar mass fraction of ∼3000. We show that this UDG is an outlier in M
star–M
halo relations, suggesting extreme stochasticity in relatively massive star-forming halos in clusters. Finally, we discuss how counting GCs offers an efficient route to determining virial masses for UDGs.
Effects of Rituximab and Infliximab Treatment on Carboxypeptidase B and Its Substrates in RA Synovium
Authors: Edginton Stefan , Hitchon Carol , Froese Warren , El-Gabalawy Hani 
Published: March 2016

Objective.We evaluated the synovial effects of 2 potent biologic rheumatoid arthritis (RA) therapies, focusing on their effect on the expression level of carboxypeptidase B (CPB) and its substrates.Methods.Patients with RA receiving infliximab (IFX; n = 9) or rituximab (RTX; n = 5) had an arthroscopic synovial biopsy at baseline and 16 weeks posttherapy. Expression of CPB, C5a, osteopontin (OPN), CD3, CD20, CD55, and CD68 was assessed by immunohistochemistry and image analysis, and compared with OA synovium. RA disease activity score was assessed at multiple timepoints. Serial serum samples were analyzed for soluble CPB and C5a levels.Results.The baseline clinical characteristics of patients receiving IFX and RTX were similar. At the time of the second biopsy, 50% of patients had achieved a European League Against Rheumatism good or moderate response. At baseline, expression of CPB, C5a, and OPN was markedly higher in RA compared with OA synovium and correlated with mononuclear cell infiltration. There was an overall reduction in synovial expression of CPB, C5a, and OPN paralleling a reduction in mononuclear cell infiltration, but these changes were not associated with clinical response. After an early reduction in serum C5a levels, these returned to baseline levels at later timepoints.Conclusion.In response to IFX and RTX treatment, RA synovial expression of CPB, C5a, and OPN decrease independently of the clinical response, reflecting the complex proinflammatory and antiinflammatory effects of this pathway.
A Multidisciplinary Evaluation Helps Identify the Antisynthetase Syndrome in Patients Presenting as Idiopathic Interstitial Pneumonia
Authors: Chartrand Sandra , Swigris Jeffrey J. , Peykova Lina , Chung Jonathan , Fischer Aryeh 
Published: March 2016

Introduction.Interstitial lung disease (ILD) is 1 possible manifestation of the idiopathic inflammatory myopathies (IIM). Occasionally, patients presenting with ILD are mistakenly diagnosed with idiopathic interstitial pneumonia (IIP), but after multidisciplinary evaluation, their ILD is determined to be because of antisynthetase syndrome (SynS) or myositis spectrum of disease.Methods.We used retrospective analytic methods to identify patients with ILD evaluated at the National Jewish Health between February 2008 and August 2014 and believed initially to have IIP but ultimately diagnosed with SynS or myositis spectrum of disease.Results.The cohort included 33 patients; most were white women with a mean age at presentation of 55 years. Their pulmonary physiologic impairment was moderate. In 31 cases, the ILD pattern by thoracic high-resolution computed tomography scan was nonspecific interstitial pneumonia (NSIP), organizing pneumonia (OP), or a combination of the 2. Surgical lung biopsy was performed in 21 patients; NSIP was the most common pattern. Less than one-third of the cohort had positive antinuclear antibodies. Two-thirds had positive SSA. All patients had either myositis-specific or myositis-associated autoantibody. Most had subtle extrathoracic symptoms or signs of SynS; 12 had an elevated serum creatine phosphokinase, but none had clinical evidence of myositis. None met the Peter and Bohan classification criteria for polymyositis/dermatomyositis.Conclusion.Among patients who present with presumed IIP, a multidisciplinary evaluation that includes the integration of clinical evaluations by rheumatologists and pulmonologists, morphologic (both histopathologic and radiographic) data, and serologic features is helpful in the detection of occult SynS or the myositis spectrum of disease.
Manuel de direction en action sociale et médico-sociale
Authors: Chauvière Michel 
Published: March 2016

L'avenir des associations passe par une fidélité constante au sillon qu'elles ont creusé depuis longtemps. Il s'agit moins d'innover que de rester fidèle aux valeurs fondatrices. Si d'aucuns — à mon avis à tort — avaient le sentiment que l'avenir associatif est incertain, qu'ils retrouvent ce qui a toujours fait la légitimité d'une association sanitaire et médico-sociale : créer les conditions pour que chaque professionnel se demande, dans ce dialogue si intime avec la personne qu'il accompagne, s'il utilise le mot juste, le geste juste, le sourire juste.