bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early evaluation of radiation-induced parotid damage with diffusion kurtosis imaging: a preliminary study
Authors: Zhou Nan , Chen Weibo , Pan Xia , He Jian , Yan Jing , Zhou Zhengyang , Yang Xiaofeng 
Published: May 2017

Background Radiation-induced parotid gland damage is a common complication of radiotherapy (RT) in patients with nasopharyngeal carcinoma (NPC), which always causes xerostomia, dysphagia, dental caries, and even sleep disorders. Early evaluation of radiation-induced parotid damage is required to facilitate early interventions. Purpose To early-evaluate radiation-induced parotid damage using diffusion kurtosis imaging (DKI) in patients with NPC undergoing RT. Material and Methods Thirty-two patients with NPC underwent DKI for parotid glands pre-RT (two weeks before RT), mid-RT (five weeks after RT began), and post-RT (four weeks after RT). Parotid volume, apparent diffusion coefficient (ADC), corrected diffusion coefficient (D), excess diffusion kurtosis coefficient (K) values, mean radiation dose, and xerostomia degrees were recorded and analyzed. Results During RT, parotid ADC (change rates = 41.3 ± 25.2% at mid-RT, 70.8 ± 34.3% at post-RT) and D (change rates = 41.9 ± 25.2% at mid-RT, 63.2 ± 30.2% at post-RT) increased, while parotid volume (atrophy rates = 31.5 ± 7.9% at mid-RT, 30.6 ± 10.3% at post-RT) and K (change rates = –17.8 ± 11.0% at mid-RT, –29.8 ± 9.0% at post-RT) decreased significantly (all P < 0.001). At post-RT, the change rate of parotid D values was significantly positively correlated with the mean radiation dose ( r = 0.455, P < 0.001). Parotid ADC, D, and K values showed excellent intra- and inter-observer agreement (intraclass correlation coefficient = 0.946-0.985). Conclusion Radiation-induced parotid damage in patients with NPC undergoing RT could be effectively evaluated by DKI in the early stage.
Two-Tunnel Transtibial Repair of Radial Meniscus Tears Produces Comparable Results to Inside-Out Repair of Vertical Meniscus Tears
Authors: Cinque Mark E. , Geeslin Andrew G. , Chahla Jorge , Dornan Grant J. , LaPrade Robert F. 
Published: May 2017

Background: Radial meniscus tears disrupt the circumferential fibers and thereby compromise meniscus integrity. Historically, radial tears were often treated with meniscectomy because of an incomplete understanding of the biomechanical consequences of these tears, limited information regarding the biomechanical performance of repair, and the technical difficulty associated with repair. There is a paucity of studies on the outcomes of the repair of radial meniscus tears. Purpose/Hypothesis: The purpose was to determine the outcomes of 2-tunnel transtibial repair of radial meniscus tears and compare these results to the outcomes of patients who underwent the repair of vertical meniscus tears with a minimum of 2-year follow-up. The hypothesis was that radial and vertical meniscus tear repair outcomes were comparable. Study Design: Cohort study; Level of evidence, 3. Methods: Patients who underwent 2-tunnel transtibial pullout repair for a radial meniscus tear were included in this study and compared with patients who underwent inside-out repair for a vertical meniscus tear. Subjective questionnaires were administered preoperatively and at a minimum of 2-year follow-up, including the Lysholm score, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Short Form–12 (SF-12) physical component summary (PCS), the Tegner activity scale, and patient satisfaction. Analysis of covariance was used to compare postoperative outcome scores between the meniscus repair groups while accounting for baseline scores. Adjusted mean effects relative to the radial repair group were reported with 95% CIs. Results: Twenty-seven patients who underwent 2-tunnel transtibial pullout repair for radial meniscus tears and 33 patients who underwent inside-out repair for vertical meniscus tears were available for follow-up at a mean of 3.5 years (range, 2.0-5.4 years). No preoperative outcome score significantly differed between the groups. There were no significant group differences for any of the 2-year postoperative outcome scores. Relative to the vertical repair group, the radial repair group exhibited an adjusted mean of −0.2 (95% CI, −5.4 to 4.9), −0.6 (95% CI, −6.6 to 5.5), and 5.1 (95% CI, −3.9 to 14.0) points on the SF-12 PCS, WOMAC, and Lysholm scores, respectively. Conclusion: The 2-tunnel transtibial pullout technique for the repair of radial meniscus tears produces similar clinical outcomes when compared with the repair of vertical meniscus tears at a mean 3.5 years’ follow-up.
Increased Magnetic Resonance Imaging Signal of the Lateral Patellar Facet Cartilage: A Functional Marker for Patellar Instability?
Authors: Falkowski Anna L. , Camathias Carlo , Jacobson Jon A. , Magerkurth Olaf 
Published: May 2017

Background:In the knee joint, predisposition for patellar instability can be assessed by an abnormal Insall-Salvati index, tibial tuberosity–trochlear groove (TTTG) distance, and abnormal shape of patella and trochlea. Given the complex anatomic features of the knee joint with varying positions of the patella during motion, the presence of a single or even a combination of these factors does not inevitably result in patellar instability. After trocheoplasty in patients with trochlear dysplasia, assessment of trochlear cartilage and subchondral bone is limited due to postoperative artifacts. Identification of presence of edema in the patellar cartilage may be helpful to identify patellar instability before and after surgery in these patients.Purpose:To determine whether increased signal intensity of the lateral patellar facet cartilage or measurements of abnormal patellofemoral articulation are associated with patellar instability before and after trochleoplasty.Study Design:Case series; Level of evidence, 4.Methods:Twenty-two patients with clinical diagnosis of patellar instability who underwent trochleoplasty, with magnetic resonance imaging (MRI) of the knee before and after surgery, were identified. The following observations and measurements were obtained in preoperative imaging: Insall-Salvati ratio, tibial tuberosity–trochlear groove (TTTG) distance, patellar shape (Wiberg), trochlear shape (Hepp), and edema in the lateral patellar facet cartilage. At 3 to 12 months after surgery, the presence or absence of edema in the cartilage of the lateral facet of the patella, the trochlear shape, and TTTG distance were reassessed. Wilcoxon matched-pairs signed rank test and Student t test were used. Interreader agreement was calculated as the Cohen κ or paired Student t test.Results:Increased cartilage signal was present in 20 patients before trochleoplasty and in 4 after trochleoplasty. Insall-Salvati ratio was greater than 1.20 in 20 patients. Patellar shape was greater than type 2 in 18 patients. Trochlear shape was greater than type 2 in 21 patients before and 7 after trochleoplasty. Mean TTTG distance was 14 mm before and 10 mm after surgery. When results before and after surgery were compared, a significant difference was found for cartilage signal, TTTG distance, and trochlear shape. Agreement for observations was moderate to substantial, and no significant differences were found for interreader agreement ( P > .05).Conclusion:Patellar cartilage at the lateral facet of the patella can be assessed after trochleoplasty despite postoperative artifacts in the trochlea. A decrease of patellar edema seems to be associated with improved femoropatellar articulation. Moreover, patellar edema may be used as a functional criterion of patellofemoral instability. This would provide additional information compared to morphologic criteria which just describe predisposing factors for femoropatellar instability.
Successful clozapine re-challenge following myocarditis
Authors: Nguyen Bang , Du Charles , Bastiampillai Tarun , Dhillon Rohan , Tibrewal Prashant 
Published: May 2017

Objective: To explore the evidence around clozapine re-challenge following myocarditis. Conclusion: This case adds to the 17 cases of clozapine re-challenge following myocarditis, of which 71% were successful (12 cases). This demonstrates that re-challenge could be performed safely and effectively in the context of clozapine-induced myocarditis, if accompanied by a strict and rigorous monitoring protocol.
Novel Use of Active Leptospermum Honey for Ringed Fixator Pin Site Care in Diabetic Charcot Deformity Patients
Authors: Lazarides Alexander L. , Hamid Kamran S. , Kerzner Michael S. 
Published: May 2017

Introduction. Open reduction with external fixation (OREF) utilizing fine wire ringed fixators for correction of Charcot deformity has gained popularity over the past decade. Pin site infections are a well-documented complication of external fixation as well as a driver of escalating health care costs. We aimed to demonstrate the safety and efficacy of a novel method of pin site care utilizing active Leptospermum honey–impregnated dressings (MediHoney) in diabetic patients undergoing deformity correction with OREF. Methods. Twenty-one diabetic patients with Charcot deformities of the lower extremity were prospectively enrolled and followed for pin site complications following OREF for deformity correction. Active Leptospermum honey dressings were applied at metal-cutaneous interfaces at the end of the OREF procedure and replaced weekly for a total of 8 weeks. Patients were monitored for pin site infections from the time of surgery until external fixator removal. Sixteen consecutive patients receiving standard OREF for Charcot deformities were evaluated retrospectively to serve as a control group. Results. Of the 21 enrolled patients, 19 underwent OREF and followed up throughout the study period. Treated patients had a mean age of 58.5 years and mean body mass index measuring 33.3 kg/m2 as documented prior to surgery. The 15 patients with hemoglobin A1c labs drawn in the 3 months preceding surgery averaged 7.5. Fixators were removed at an average of 12.1 weeks after adequate bony healing. Of the 244 pin sites in 19 patients, 3 pin sites (1.2% of pins) in 2 patients (10.5% of patients) showed evidence of superficial infection. All infections resolved with oral antibiotics. Infection rates were significantly reduced when compared to the standard care control group. Conclusions. Pilot data in a prospectively collected case series demonstrate safety and efficacy of active Leptospermum honey–impregnated dressings when used for fine wire ringed fixator pin site care in diabetic Charcot deformity patients. Further investigation in the form of a prospective randomized controlled study is warranted to demonstrate the potential value of this novel intervention. Levels of Evidence: Level IV
Cervical Disc Arthroplasty: A Comprehensive Review of Single-Level, Multilevel, and Hybrid Procedures
Authors: Laratta Joseph L. , Shillingford Jamal N. , Saifi Comron , Riew K. Daniel 
Published: May 2017

Study Design: Systematic review. Objectives: Degenerative disc disease and spondylosis resulting in radiculopathy and retrodiscal myelopathy are among the most frequently encountered cervical spinal disorders. Traditionally, anterior cervical discectomy and fusion (ACDF) has successfully achieved neural decompression and restored intradiscal height in these conditions. Unfortunately, nonunion and iatrogenic adjacent segment pathology associated with fusion procedures in the cervical spine has led to an interest in motion-preserving procedures. Cervical disc arthroplasty (CDA) was developed in hopes of preserving cervical biomechanics while mitigating the complications associated with ACDF. Through a systematic review of both published and ongoing studies on single- and multilevel CDA, and hybrid surgeries, we aim to provide evidence for their safety and efficacy in the treatment of various cervical pathologies. Methods: A systematic search of several large databases, including Cochrane Central, PubMed, ClinicalTrials.gov , and the World Health Organization International Clinical Trials Registry was conducted to identify published studies and ongoing clinical trials on CDA and hybrid surgery. Results: Among the relevant studies reviewed, 3 were randomized controlled trials, 2 systematic reviews, as well as multiple prospective case series, biomechanical studies, and meta-analyses. Conclusion: Over the past decade, multiple high-quality studies have shown that single-level CDA can offer equivalent clinical outcomes with a reduction in secondary procedures and total cost when compared to ACDF. However, more recently there has been an increasing prevalence of 2-level CDA and hybrid surgery. Although the data regarding these multilevel procedures is less robust, it appears that they may be as effective as their single-level counterparts.
Can Posterior Lumbar Instrumentation and Fusion Be Overpowered by Anterior Lumbar Fusion With Hyperlordotic Cages? A Cadaveric Study
Authors: Wigner Nathan , Kadam Abhijeet , Saville Philip , Arlet Vincent 
Published: May 2017

Study design: Technical report on cadavers. Objective: To evaluate preliminary feasibility and safety of lumbar sagittal alignment correction with anterior hyperlordotic cages used to overpower previous posterior spinal instrumentation. Methods: Hyperlordotic 30° anterior lumbar interbody fusion (ALIF) cages were inserted in collapsed L5-S1 disc space of 2 cadavers to overpower prior posterior L5-S1 pedicle screws and rod constructs. A distinct technique of opening up the disc space and creation of intersegmental lordosis was employed using a large endplate distractor and transforaminal lumbar interbody fusion (TLIF) paddle distractor. Assessment of increase in the intersegmental lordosis (ISL) was made using lateral fluoroscopic imaging. Postprocedural computed tomography (CT) scans were obtained to evaluate any failure of posterior instrumentation and to serve as a surrogate marker for bone quality. Results: The 2 cadavers selected (from an available number of 10) were males: 82 and 84 years of age, respectively. Both had marked L5-S1 disc space collapse. The ISL achieved with hyperlordotic cages was 27.6° for the first cadaver (up from 4.9°) and 23.1° for the second one (up from 4.6°). No obvious screw-rod failure or cutout of instrumentation occurred. Postprocedure CT scans did not reveal any loosening of screws or cutout through endplates. Hounsfield unit values calculated on axial CT cuts were 73.50 (osteoporosis) and 80.70 (osteopenia) respectively for the 2 cadavers. Conclusion: Based on the results of the cadaveric experiment, overpowering of posterior instrumentation can be effectively achieved. Biomechanical and clinical studies are indicated to further evaluate the suitability and safety of this technique.
Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults
Authors: Milne Paul , Bigley Venetia , Bacon Chris M. , Néel Antoine , McGovern Naomi , Bomken Simon , Haniffa Muzlifah , Diamond Eli L. , Durham Benjamin H. , Visser Johannes , Hunt David , Gunawardena Harsha , Macheta Mac , McClain Kenneth L. , Allen Carl , Abdel-Wahab Omar , Collin Matthew 
Published: May 2017

Key Points
Bone marrow progenitors, monocytes, and myeloid DCs contain BRAFV600E alleles in adults with LCH and ECD. Mutant allele distribution is not disease specific, but precursors have distinct LCH-like and macrophage differentiation capacities.
Association between diffuse myocardial fibrosis and diastolic dysfunction in sickle cell anemia
Authors: Niss Omar , Fleck Robert , Makue Fowe , Alsaied Tarek , Desai Payal , Towbin Jeffrey A. , Malik Punam , Taylor Michael D. , Quinn Charles T. 
Published: May 2017

Key PointsDiffuse myocardial fibrosis is a common and novel mechanism of heart disease in SCA that can be detected noninvasively. Diffuse myocardial fibrosis is strongly associated with diastolic dysfunction in individuals with SCA.
Replenishing exosomes from older bone marrow stromal cells with miR-340 inhibits myeloma-related angiogenesis
Authors: Umezu Tomohiro , Imanishi Satoshi , Azuma Kenko , Kobayashi Chiaki , Yoshizawa Seiichiro , Ohyashiki Kazuma , Ohyashiki Junko H. 
Published: May 2017

Key Points
Exosomal miR-340 derived from young BMSCs inhibited tumor angiogenesis via the HGF/c-MET signaling pathway. The anti-angiogenic effect of exosomes from older BMSCs was restored by direct transfection of young BMSC-derived exosomal miRNAs.
The incidence and natural history of dasatinib complications in the treatment of chronic myeloid leukemia
Authors: Fox Lucy C. , Cummins Katherine D. , Costello Ben , Yeung David , Cleary Rebecca , Forsyth Cecily , Tatarczuch Maciek , Burbury Kate , Motorna Olga , Shortt Jake , Fleming Shaun , McQuillan Andrew , Schwarer Anthony , Harrup Rosemary , Holmes Amy , Ratnasingam Sumita , Chan Kah-Lok , Hsu Wei-Hsun , Ashraf Asma , Putt Faye , Grigg Andrew 
Published: May 2017

Key PointsPrescribing appropriately for age and cardiovascular risk is likely to result in minimal permanent toxicity-related dasatinib cessation. CML patients on dasatinib with pleural effusion are more likely to have achieved MR4.5 after 6-month therapy than those without effusion.
Can glypican‐3 be a disease‐specific biomarker?
Authors: Chen Chaolei , Huang Xiaomin , Ying Zhaojian , Wu Dengmin , Yu Yani , Wang Xiangdong , Chen Chengshui 
Published: May 2017

AbstractBackgroundGlypican‐3 (GPC3) is a cell surface‐bound proteoglycan which has been identified as a potential biomarker candidate in hepatocellular carcinoma, lung carcinoma, severe pneumonia, and acute respiratory distress syndrome (ARDS). The aim of our review is to evaluate whether GPC3 has utility as a disease‐specific biomarker, to discuss the potential involvement of GPC3 in cell biology, and to consider the changes of GPC3 gene and protein expression and regulation in hepatocellular carcinoma, lung cancer, severe pneumonia, and ARDS.ResultsImmunohistochemical studies have suggested that over‐expression of GPC3 is associated with a poorer prognosis for hepatocellular carcinoma patients. Expression of GPC3 leads to an increased apoptosis response in human lung carcinoma tumor cells, and is considered to be a candidate lung tumor suppressor gene. Increased serum levels of GPC3 have been demonstrated in ARDS patients with severe pneumonia.ConclusionsGlypican‐3 could be considered as a clinically useful biomarker in hepatocellular carcinoma, lung carcinoma, and ARDS, but further research is needed to confirm and expand on these findings.
A game-theory modeling approach to utility and strength of interactions dynamics in biomedical research social networks
Authors: Siqueiros-García J. Mario , García-Herrera Rodrigo , Hernández-Lemus Enrique , Alcalá-Corona Sergio 
Published: May 2017

AbstractPurposeCollaboration has become a cornerstone in biomedical research today. In contrast to physics which has a long history and experience in collaborative projects, biology is only recently becoming an evermore collaborative discipline. In this article we explore the effect of a collaboration network on the distribution of players having access to certain amount of resources from other players in the network and the distribution of the strength of interactions among them. We are interested in how they affect each other in the context of a network of scientific collaboration under the idea that while researchers are interested in maximizing their utilities, they also know that it is important to invest in building collaborative relationships.MethodsWe implemented two games played simultaneously: one for maximizing individual utility based on the iterated prisoner’s dilemma; the other, a coordination game for maximizing the connection strength between players. We tested our simulation on a biomedical research community network in México and compared the results with Erdös–Renyí, a Watts–Strogatz small-world and Barabási–Albert topologies.ResultsDifferent topologies display different global utility and global strength of interaction distributions. Moreover, the distribution of utility and strength of interaction in the researchers network is similar to that of Barabási–Albert and Watts–Strogatz topologies, respectively.ConclusionsData related to Science, from co-authorships to Scientists' movility are increasingly becoming available. We think that the readiness of these sort of data is a great opportunity for scientists interested in the social dynamics of science, especially in the context of computational social science.
Production with Risk Hedging—Optimal Policy and Efficient Frontier
Authors: Wang Liao , Yao David D. 
Published: May 2017

Demand for many products may depend on the price of a tradable asset or on the economy in general. For example, demand for equipment that plants or harvests corn correlates with the corn price on the commodity market, and discount stores experienced increased sales revenue during the last recession. Thus, we model demand as a stochastic process with two components: in addition to the usual Gaussian component reflecting demand volatility, there is a drift component taking the form of a function of a tradable asset price. (In the case of dependence on the general economy, the asset price can be a broad market index, such as the S&P 500 Index.) With this demand model, we study the one-time production quantity decision along with a real-time risk-hedging strategy over a given planning horizon (the production cycle). Pursuing a mean-variance formulation, we derive the optimal solution to both production and hedging decisions. We give a complete characterization of the efficient frontier and quantify the improvement in risk-return trade-off achieved by the hedging strategy. Furthermore, we show that the hedging strategy is self-financing in the sense that the expected total wealth from both production and hedging stays nonnegative at all times. The online appendix is available at https://doi.org/10.1287/opre.2017.1597
EXPERIENCIAS PEDAGÓGICAS: Educar en las primeras infancias: una experiencia de formación docente en nutrición y alimentación saludable
Authors: Ravelli Sandra , Manuale Marcela 
Published: May 2017

El presente trabajo analiza una experiencia de formación docente centrada en la Educación Alimentaria Nutricional, que permitió fortalecer vínculos entre la universidad y otros nivelesdel sistema educativo, promoviendo intervenciones en la intersección entre educación, salud y primeras infancias. Desde la propuesta del Programa Nacional de Formación Permanente, del Ministerio de Educación de la Nación, se propuso desde la Facultad de Bioquímica y Ciencias Biológicas (FBCB) de la Universidad Nacional del Litoral (UNL) un curso de capacitación denominado “Salud, nutrición y educación infantil: construyendo estrategias en el nivel inicial“, donde participaron docentes y directivos de nivel nicial, docentes del primer ciclo de educación primaria, alumnos avanzados de formación docente, especialmente del Profesorado de Educación Física y alumnos avanzados de la carrera de Licenciatura en Nutrición (LN) y de Terapia Ocupacional FBCB-UNL. El desarrollo de esta experiencia de formación pedagógica posibilitó el diseño y desarrollo de propuestas educativas contextualizadas, transfiriendo los ejes vinculados a la salud y nutrición trabajados a las prácticas de enseñanza en los niveles involucrados.