bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ketorolac Dose Ceiling Effect for Pediatric Headache in the Emergency Department
Authors: Lefchak Brian , Morgan Danielle , Finch Mike , Madhok Manu , Raschka Mike 
Published: October 2024

OBJECTIVE
This study sought to demonstrate a non-inferiority analgesic ceiling effect previously ­demonstrated within adults for pediatric patients receiving a maximum ketorolac dose of 15 mg.

METHODS
We conducted a retrospective cohort study of pediatric ED patients weighing at least 60 kg treated with 30 mg (pre-intervention) or 15 mg (post-intervention) intravenous (IV) ketorolac for headache. The primary outcome included patient-reported pain scores. Additional outcomes included demographic variables, adjunct medication use and adverse effects. Categorical data were evaluated using a χ2 test, and numerical data were evaluated using an ANOVA F test and Welch 2-sample t test.

RESULTS
The pre- and post-intervention groups included 216 and 62 patients, respectively. Overall demographics were similar between the groups (72.3% female, 49.3% White/Caucasian, mean age 15.5 years, mean weight 79.2 kg, and mean baseline 10-point pain score 7.5). Twelve (5.6%) in the pre-intervention group required rescue analgesic compared with 2 patients (3.2%) in the post-intervention group (p = 0.416). In the pre-intervention group, 198 patients (91.7%) received nausea medication compared with 52 patients (83.9%) in the post-intervention group (p = 0.087). Mean 10-point pain scores following ketorolac administration decreased by 3.9 in the pre-intervention group compared with 5.1 in the post-intervention group (p = &lt; 0.001). Common (0.9%) or rare (0.9%) side effects were infrequent and only seen in the pre-intervention group patients.

CONCLUSIONS
Truncating the maximum intravenous ketorolac dose in pediatric patients at least 60 kg in weight to 15 mg compared with 30 mg results in effective analgesia in pediatric patients with headache. Future research could explore differences in admission rates, treatment of other indications, or treatment with multiple-dose regimens.
Impact of Age and Concurrent Antiseizure Medication Use on Lacosamide Dose to Concentration Ratio and Dosing in Pediatric Patients
Authors: Woods Megan , Phelps Stephanie J. , Christensen Michael L. , Meibohm Bernd , Wheless James W. 
Published: October 2024

OBJECTIVE
To evaluate age, adjunctive antiseizure medication (ASM), and specific ASMs on lacosamide (LCM) weight normalized dose-to-concentration ratio (DCR) and US Food and Drug Administration (FDA) dosing guidelines in pediatric patients.

METHODS
Patients 1 mo to ≤18 years with a LCM serum concentration between October 2009 and June 2017 were considered. Demographics, LCM DCR, and adjunctive ASM were recorded. LCM DCR/hr was used as a surrogate for clearance. Data were stratified by age (1 mo-&lt; 2 yr; ≥ 2–6 yr; ≥ 6–12 yr; and ≥12–≤18 yr), FDA dosing weights, and ASM potential to interaction with LCM.

RESULTS
There were 646 sera (380 patients) with median dose 8.36 mg/kg/day (IQR, 5.92–11.16). 50.2% of doses were within FDA-weight guidelines; however, 40.4% exceeded recommendations. Most (81.3%) LCM concentrations were between 2 and 12 mg/L. A difference existed in DCR between ages, with those &lt;2 years having the highest DCR (p &lt; 0.001). Moving across age groups, the DCR decreases by 30.7%, 50.5%, and 63.4%. There was a weak (r2 = 0.073) but significant (p &lt; 0.001) negative correlation between DCR and age. 84.8% received adjunctive ASM consisting of at least one of 31 different ASMs. DCR was higher with adjunctive ASMs compared with monotherapy [0.061 (0.039–0.095) vs 0.043 (0.030–0.062)], respectively (p &lt; 0.001) and was greatest with inducers. Phenobarbital increased DCR by 2.6-fold, topiramate by 72.1%, and clobazam by 32.6%. Inhibitors had no effect.

CONCLUSIONS
The correlation between age and DCR was weak, accounting for 6% of variability. Strong inducers significantly increased DCR. Synergy may exist when multiple inducers are given. Weak inhibitors did not affect DCR. Those ≥6 to 11 kg, ≥30 to 50 kg, and those given strong inducers may require larger ­initial LCM doses. Serum concentrations should be used to individualize dosing, especially in those receiving strong inducers.
The Influence of Logistics Activity on Sustainable Performance of Air Cargo Business in Thailand
Authors: Hongsakul Bharis , Chuaychoo Ichayaporn 
Published: October 2024

This research applies logistics management concepts to sustainable business operations in the context of air cargo businesses in Thailand. The study aims to understand how logistics activities impact the sustainable performance of air cargo businesses. The objectives of this study were to examine: 1) logistics activities in air cargo businesses in Thailand, and 2) the influence of logistics activities on the sustainable performance of the air cargo business. This study consists of descriptive research, utilzing a questionnaire for data collection. The sample consisted of 424 employees of air cargo businesses operating in Thailand. The findings reveal that all 9 logistics activities significantly influenced the sustainable performance of air cargo businesses in Thailand, in terms of economic, social, and environmental performance, where Customer Services and Support (CSS) had the highest average value with a mean value of 5.90 (S.D. = 0.723).
Regarding the results of the study of influences, Facilities Site Selection, Warehousing, and Storage (FWS) was found to strongly impact Economic Performance (ECOP) with a β value of .740. Meanwhile, Reverse Logistics (RL) had the greatest impact on Social Performance (SOCP) with a β value of 0.843, and Transportation (TRAN) had the greatest influence on Environmental Performance (ENVP), with a β value of 0.749.
The findings can support the introduction of business guidelines to enhance competitiveness and enable the achievement of sustainable success, offering encouragement for Thailand as a key air cargo hub for Southeast Asia. Moreover, the study can be used to enhance academic knowledge in the field of logistics and contribute to the future sustainable performance of the air cargo business.
Strategic Execution Drivers on Performance of Private Hospitals in Nairobi City County, Kenya.
Authors: Mola Nancy Mating’i , Sije Antony , Mangana Robert 
Published: October 2024

This study assess the influence of strategic execution drivers, specifically strategic leadership and resource allocation, on the performance of private hospitals in Nairobi County, Kenya. Strategy formulation often succeeds, but execution presents significant challenges, particularly in converting plans into successful outcomes. The research highlights the critical role of strategic leadership in shaping organizational culture, decision-making, and employee engagement, while resource allocation directly impacts hospitals' capacity to deliver quality healthcare and achieve operational efficiency. As Nairobi’s healthcare sector grows and competition intensifies, private hospitals must excel in strategy execution to maintain competitiveness. Despite their focus on clinical care, many hospitals face gaps in implementing strategic management, leading to performance deficiencies. Using Transformational Leadership Theory and the Resource-Based View (RBV) theory, the study explores how effective leadership and resource management drive operational success. The research employed a descriptive design, targeting key decision-makers across 62 private hospitals. Results from the analysis indicate that both strategic leadership and resource allocation play a significant role in shaping hospital performance, with correlations of 0.70 and 0.80, respectively. Findings suggest that private hospitals in Nairobi must prioritize aligning leadership and resource strategies to improve performance, meet operational goals, and enhance patient outcomes in an increasingly competitive environment
Calculating of Month and Day of Birth Ahead of The Wedding Day in The Javanese Culture: Perspective of Maqashid Al-Syari’ah
Authors: Mas'ud  
Published: October 2024

Background. Counting the month and day of birth is ritual; respect for traditions and beliefs that have existed for a long time in society; considered as one way to ensure that the couple starts their new life well and receives blessings from God.
Aim. Examines the role of Javanese culture in calculating the month and day of birth in relation to the upcoming wedding, as well as its relevance from the perspective of maqashid al-shari’ah.
Method. Qualitative approach involving in-depth interviews and participatory observation. Thematic analysis was employed to identify key themes of data and to connect with the theory of maqashid al-shari’ah.
Results. The practice carries values aligned with maqashid al-shari’ah, such as the protection of offspring and the formation of harmonious family relationship; provides spiritual and social reinforcement for the Javanese community; fostering mutual respect and strengthening the bonds between individuals and their traditions and beliefs.
Percepción de la calidad del proceso de enseñanza-aprendizaje en las dimensiones de planificación, ejecución, evaluación en estudiantes de posgrado de la Universidad Emiliano Zapata
Authors: Ayala García Héctor Arturo , Ramírez Vázquez Ileana Aidee , Flores Godínez Vicente 
Published: October 2024

En la Universidad Emiliano Zapata, “tiene como política garantizar una enseñanza que destaque por el nivel académico y oportunidades para todos” (Universidad Emiliano Zapata, 2024). De manera que se analizaron la calidad del aprendizaje-enseñanza en las dimensiones de Planificación, ejecución, evaluación (Melgarejo Solís, Gianina, & Rivas Díaz, Luisa Hortensia, 2021), expectativas académica y laboral en estudiantes de posgrado de ingeniería, aplicándose a 37 estudiantes, 23 de las Maestría Ingeniería Industrial en Sistemas (65% masculino y 34% femenino) y 14 de la Maestría en Gestión y Administración, 72% femenino y 28% masculino; obteniendo que 32 alumnos son originarios del Estado de Nuevo León y 5 foráneos, residentes en 7 municipios de la metrópoli regiomontana, siendo 18 del sexo femenino y 19 masculino, mostrando cierta equidad de género, en edad se reconocieron 4 grupos; 15 alumnos de 20-29 años; 12 de 30-39 años; 8 de 40-49 años y 2 de 50-59 años, se identificó en la dimensión de Calidad, Muy de acuerdo 65.2%, De acuerdo 31.8%, Ni de acuerdo ni en desacuerdo 2.8% y En desacuerdo 0.2%; en expectativa académica, Muy de acuerdo 62.2%, De acuerdo 35.1% y Ni de cuerdo ni en desacuerdo 2.7%; en expectativa laboral, Muy de acuerdo 62.2%, De acuerdo 35.1% y Ni de acuerdo ni en desacuerdo 2.7%.
Desarrollo de Competencias Digitales para los Estudiantes de Bachillerato de la Ciudad de Otavalo, provincia de Imbabura – Ecuador
Authors: Pavón Anrango Juan Carlos , Cajo Guallasamín Vanesa Estefanía 
Published: October 2024

El presente artículo aborda el estudio sobre las competencias digitales de los estudiantes de bachillerato de la ciudad de Otavalo, provincia de Imbabura – Ecuador. Considerando el uso de las nuevas plataformas digitales en la educación, el presente proyecto de investigación tiene como objetivo analizar las competencias digitales que el estudiante tiene con el uso de la plataforma Suite de Google, conjunto de herramientas ofimáticas que sirven para mejorar de trabajo colectivo, grupal o individual. Su enfoque fue descriptivo, por que nos permitio describir, explicar, analizar, y comparar las características de una población o situación en particular; transversal por que se recopilo la información de una población de 384 estudiantes de 5 unidades educativas mediante un formulario de Google Forms en el periodo de agosto 2022 a junio 2023, y cuantitativo con un diseño metodológico no experimental, por que se basó especialmente en la observación de los hechos exactamente como suceden en su contexto natural. Con esta investigación se pudo observar que los estudiantes hacen un énfasis en mejorar de sus competencias digitales con un 95%%, de deseo de aprender y un 5% que no tienen interes en desarrollar mayor destrezas que las que ya tienen.
Akulturasi Budaya Jawa dengan Budaya Islam pada Bulan Muharram di Desa Brayo Wonotunggal Kabupaten Batang
Authors: Maya Ika Trisnawati  , Hana Dian Malasari  , Alvian Varihul Mustavid  , Ahmad Noor Afifuddin  , Muhammad Nadhiful Hakim  , Pradipta Kurniasanti  
Published: October 2024

Nyadran is a series of traditional ceremonies, which are part of cultural heritage and believe that certain places are sacred or holy places. Nyadran traditions like this are a from of salvation carried out as a from of gratitude and respect for ancestors. The data collection technique used in this research was interviews with the main sources, the head of the Nyadran committee and the of Brayo village. The location of this research was in Ujung Biru Hamlet, Brayo Village, Wonotunggal District. Nyadran activities in Ujung Biru Hamlet are held in the month of Muharrom because Muharrom is not the Hijri New Year. Nyadran implementation in Brayo Village has been carried out since ancient times, as time goes by, the nyadran tradition has undergone many changes
A essência do teatro
Authors: Barba Eugenio 
Published: October 2024

Neste artigo, Eugenio Barba analisa a “história subterrânea” da tradição teatral do século XX e sua própria trajetória artística, ressaltando o “caminho da recusa” como o seu ethos profissional e o de seus antepassados — os protagonistas da Grande Reforma teatral do início do século XX —, dos quais se define como “nada mais que um epígono”. Partindo da pergunta “o que resta do teatro?”, traça as linhas que definem a essência da tradição teatral que, junto com seus companheiros e companheiras do Odin Teatret, inventou.
A memória como dispositivo de resistência
Authors: Rodrigues Éder , Rojo Sara 
Published: October 2024

Este artigo concentra suas discussões em torno do processo de criação da peça A mulher que andava em círculos, produzida pelo Mayombe Grupo de Teatro. O trabalho dramatúrgico com a memória coletiva da América Latina pelo prisma de uma mulher impedida de lembrar por causa das limitações da memória é o argumento dessa peça, que passou por uma série de transformações durante os ensaios ao assumir no corpus do texto o olhar estético-político da direção e as intervenções performáticas da atriz. A linha tênue entre ficção e história, entre o esquecimento e os alardes do contexto atual compõe a tessitura da peça estruturada a partir dos ecos silenciados extraídos dos escombros “oficiais” da história. Nessa linha, trazer ao presente como um dispositivo de resistência diante dos regimes opressores tornou-se um trajeto inevitável dentro da montagem, operada justamente na fronteira do poético com as micropolíticas.
Adaptações sobre as virtualidades do duplo no teatro
Authors: Dias de Almeida Berger Carolina 
Published: October 2024

Este artigo parte da virtualidade do Duplo no teatro, de Antonin Artaud. Visa refletir sobre as poéticas dos Duplos digitais em performances intermídia contemporâneas. A partir desta leitura, reviso o conceito de Duplo Digital pensado por Steve Dixon a partir do universo da performance digital. Por fim, chego ao que nomeio como Digital Self, desde um contexto prático-teórico de criação e investigação da geração de presença em performances intermídia com recursos de programação computacional para pensar o Duplo como imagem sintética do Self.
Antonin Artaud and reverberations
Authors: Da Costa Dias Luciana , Mantovani Gomes Barbosa Tamira 
Published: October 2024

Antonin Artaud (1896-1948) needs no introductions. His name stands out among the great creators and thinkers of the Performing Arts in the 20th Century, especially when it comes to the search for a theatrical language other than drama, but body-based in its expressiveness and movement – he discusses not only the body as a hieroglyph – matrix of meanings in his Theatre of Cruelty – but lately the body of the performer as a free, anarchic body as well (the famous, and many times misunderstood, body-without-organs). Artaud’s contributions to construct the contemporary theatre are striking in their innovative and experimenting character, in all the multiplicity, untamedness, physics and intensity of the contemporary scene. Therefore, this special issue intends to widen the space for debate and connect scholars whose own works are pervaded by reverberations of Artaud’s work.
Iluminação e composição cênica
Authors: Deiró Nosella Berilo Luigi , De Paula Resende Laura 
Published: October 2024

A partir do estudo da obra O teatro e seu duplo, de Antonin Artaud (2006), nela considerando suas reflexões sobre o uso da luz na cena, o presente artigo tem como objetivo realizar uma análise de caso sobre a iluminação cênica do espetáculo Soft Porn. Os procedimentos metodológicos tiveram como base o levantamento das características do processo criativo do espetáculo que contribuíram para associações com a proposta artaudiana sobre metodologias horizontais e a valorização da linguagem da cena, bem como os espaços não específicos de teatro. Desse modo, tornou-se viável a análise da iluminação do espetáculo pela perspectiva da experiência sensível compartilhada entre público e cena no espaço. O que se pretende, nesse contexto, é, a partir do olhar para uma obra cênica contemporânea, considerando seus processos e resultados, contribuir para um início de reflexão sobre um possível pensamento artaudiano referente à iluminação que pudesse orientar práticas contemporâneas no campo das artes cênicas – uma vez que o autor não deixou escritos definitivos nesse campo nem realizou experiências práticas a partir de suas ideias.
Comparative transcriptome and hormone analyses of roots in apple among three rootstocks with different rooting abilities
Authors: Li Zhongyong , Cao Yang , Zhu Jie , Liu Jin , Li Feng , Zhou Shasha , Zhang Xueying , Xu Jizhong , Liang Bowen 
Published: October 2024

Background
Root plays an important role in the growth and development of fruit trees; however, the molecular mechanisms behind the differences among rootstock varie-ties remain unclear.

Methods
This study examined the effects of different rootstocks on root structure and the endogenous hormone content of 1-year old apple seedlings in combinations of Tianhong 2 (T2)/Malus robusta (HT), T2/G935, and T2/Jizhen 2 (J2).

Results
The results showed that the T2/HT treatment had greater root length, surface area, volume, average diameter, tips and forks, followed by G935 and J2. In T2/HT leaves and roots, the indole-3-acetic acid (IAA) and gibberellins (GA3) levels were highest, and the abscisic acid (ABA) levels were the lowest. A root transcriptome analysis detected 10,064, 10,511, and 8,719 differentially expressed genes in T2/HT vs. T2/G935, T2/HT vs. T2/J2, and T2/J2 vs. T2/G935, respectively. The analysis of Gene Ontology (GO) terms indicated a significant enrichment in biological processes, cellular components, and molecular functions. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that plant hormone signaling, MAPK signaling pathway–plant, and plant–pathogen interaction played important roles in differences in the rooting ability of different rootstocks. In addition, some key differential genes were associated with root growth and development and were involved in these metabolic pathways. This study is important for enriching theoretical studies of fruit tree roots.
Phytochemical Screening and Safety Assessment of a Polyherbal Tea Formulation of Lippia Multiflora, Zinger Officinale and Mentha Piperita
Authors: Epiphanie N'DRI Quesnelle , Elisée KPOROU Kouassi , Sitapha OUATTARA , Maxwell BEUGRE Avit Grah , Gisèle KOUAKOU-SIRANSY 
Published: October 2024

Aims: Lippia multiflora, Zingiber officinale, and Mentha piperita are aromatic plants known for their health benefits. This study the phytochemical composition and evaluate the safety of a tea made from them for safe human consumption.
Methodology: For tea formulations, powder of each plant was prepared and weighed in specific proportions to formulate five different polyherbal tea. A hedonic test was then conducted on each formulation to evaluate consumer apprecation. Phytochemical composition was carried out by coloration and precipitation tests. This was followed by acute and subacute toxicity tests.
Results: Among the five formulations, formulation 4 consisting of “55% L. multiflora, 30% Z. officinale and 15% M. piperita" was the most appreciated tea with a value of 8.01. Regarding safety of the formulation 4, no deaths or signs of intoxication were observed. Subacute toxicity tests showed that the polyherbal tea 4 has no adverse effects on biochemical parameters. Apart from white blood cells for which there was an increasing number from 14.40 ± 0.50 103/uL to 19.30 ± 0.40 103/uL in comprarison to the control group (10.60 ± 0.90 103/uL), the haematological parameters were not significantly modified. This Tea formulation ²was rich in compounds such as alkaloids, polyphenols, flavonoids, saponosides, sterols and polyterpenes, leucoanthocyanins, and mucilages, which made its consumption more attractive.
Conclusion: The polyherbal tea 4 which was the most appreciated, was rich in secondary metabolites such as alkaloids, polyphenols, flavonoids, saponosides, sterols and polyterpenes, leucoanthocyanins, and mucilages, and was not toxic to wistar rats.
Die Deutsche Filmförderung und ihre wichtige Reform
Authors: Böhning Björn 
Published: October 2024

Zusammenfassung
Für den Filmstandort Deutschland ist es fünf vor zwölf. Nationale und internationale Produktionen wandern ins europäische Ausland ab, internationale Auftraggeber bauen Oligopole auf und Arbeitsplätze gehen verloren. Eine Lösung: Im Rahmen der Novellierung der Filmförderung braucht es eine Investitionsverpflichtung für Sender und Streamer sowie Steueranreize für Unternehmen, die in begeisternde Geschichten investieren.
Input‐variable sensitivity assessment for sediment transport relations
Authors: Fernández Roberto , Garcia Marcelo H. 
Published: July 2017

AbstractA methodology to assess input‐variable sensitivity for sediment transport relations is presented. The Mean Value First Order Second Moment Method (MVFOSM) is applied to two bed load transport equations showing that it may be used to rank all input variables in terms of how their specific variance affects the overall variance of the sediment transport estimation. In sites where data are scarce or nonexistent, the results obtained may be used to (i) determine what variables would have the largest impact when estimating sediment loads in the absence of field observations and (ii) design field campaigns to specifically measure those variables for which a given transport equation is most sensitive; in sites where data are readily available, the results would allow quantifying the effect that the variance associated with each input variable has on the variance of the sediment transport estimates. An application of the method to two transport relations using data from a tropical mountain river in Costa Rica is implemented to exemplify the potential of the method in places where input data are limited. Results are compared against Monte Carlo simulations to assess the reliability of the method and validate its results. For both of the sediment transport relations used in the sensitivity analysis, accurate knowledge of sediment size was found to have more impact on sediment transport predictions than precise knowledge of other input variables such as channel slope and flow discharge.