bluuebunny/crossref_metadata_2025_split huggingface dataset:
Further evidence that peritraumatic 17β-estradiol levels influence chronic posttraumatic pain outcomes in women, data from both humans and animals
Authors: Son Esther , Gaither Rachel , Lobo Jarred , Zhao Ying , McKibben Lauren A. , Arora Rhea , Albertorio-Sáez Liz , Mickelson Jacqueline , Wanstrath Britannia J. , Bhatia Simran , Stevens Jennifer S. , Jovanovic Tanja , Koenen Karestan , Kessler Ronald , Ressler Kerry , Beaudoin Francesca L. , McLean Samuel A. , Linnstaedt Sarah D. 
Published: September 2024

Abstract
Chronic posttraumatic pain (CPTP) is common after traumatic stress exposure (TSE) and disproportionately burdens women. We previously showed across 3 independent longitudinal cohort studies that, in women, increased peritraumatic 17β-estradiol (E2) levels were associated with substantially lower CPTP over 1 year. Here, we assessed this relationship in a fourth longitudinal cohort and also assessed the relationship between E2 and CPTP at additional time points post-TSE. Furthermore, we used a well-validated animal model of TSE to determine whether exogenous E2 administration protects against mechanical hypersensitivity. Using nested samples and data from the Advancing Understanding of RecOvery afteR traumA study (n = 543 samples, 389 participants), an emergency department–based prospective study of TSE survivors, we assessed the relationship between circulating E2 levels and CPTP in women and men using multivariate repeated-measures mixed modeling. Male and ovariectomized female Sprague Dawley rats were exposed to TSE and administered E2 either immediately after or 3 days post-TSE. Consistent with previous results, we observed an inverse relationship between peritraumatic E2 and longitudinal CPTP in women only (β = −0.137, P = 0.033). In animals, E2 protected against mechanical hypersensitivity in female ovariectomized rats only if administered immediately post-TSE. In conclusion, peritraumatic E2 levels, but not those at post-TSE time points, predict CPTP in women TSE survivors. Administration of E2 immediately post TSE protects against mechanical hypersensitivity in female rats. Together with previous findings, these data indicate that increased peritraumatic E2 levels in women have protective effects against CPTP development and suggest that immediate post-TSE E2 administration in women could be a promising therapeutic strategy for reducing risk of CPTP.
A case report of bilateral persistent sciatic artery: Bilateral aneurysm with thromboembolism of the right lower extremity
Authors: Mao Yi , Chen Li , Liu Zhi-Xing 
Published: September 2024

Rationale:
Persistent sciatic artery (PSA) is a rare congenital vascular anomaly. The sciatic artery, which normally regresses to become the inferior gluteal artery during fetal development, persists as a direct branch of the internal iliac artery.

Patient concern:
We report a 78-year-old female who was admitted due to sudden pain, numbness, and loss of sensation in the right lower limb.

Diagnoses:
Acute thromboembolism in the right leg, bilateral PSA, and bilateral aneurysm.

Interventions:
After the super-selective embolization, lower limb arterial thrombolysis treatment was performed. After symptom relief, a computed tomography angiography was conducted to clarify the vascular variations.

Outcomes:
After relief of lower limb embolism, long-term antiplatelet therapy was administered.

Lessons:
When performing an ultrasound examination of PSA, careful identification of the arterial anatomy, evaluation of blood flow, assessment of surrounding structures, comparison between sides, and correlation with clinical symptoms are crucial to accurately diagnose this rare vascular anomaly.
Clinical efficacy and adverse effects of LMWH combined with ASA in the treatment of RSA: A meta-analysis and systematic review
Authors: Liu Fang , Shi Dongmei , Jin Rui , Yu Xinyou 
Published: September 2024

Background:
The incidence of recurrent spontaneous abortion (RSA) in the clinic shows an increasing trend year by year, and the coagulation status of this group of patients is mostly relatively abnormal. Currently, commonly used drugs in clinical practice include Aspirin (ASA) and low molecular weight heparin (LMWH), but their optimal treatment remains controversial. We aimed to evaluate the clinical efficacy and adverse effects of LMWH combined with ASA in the treatment of RSA.

Methods:
Randomized controlled trials of LMWH combined with ASA for RSA were searched in the databases of PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Wanfang, VIP, and Chinese Biomedical Literature Service System from the construction of the database to June 2024. Data were analyzed using Review Manager 5.3 and Stata software. Dichotomous variables were analyzed using relative risk (RR) and 95% confidence interval (CI) as their statistics. The included literature was assessed for bias and risk of bias of eligible studies using Cochrane risk of bias tool. The risk of bias was evaluated based on the evaluation criteria recommended by the Cochrane Guidance Manual for Systematic Evaluation.

Results:
A total of 32 papers with a total of 3397 patients with RSA were finally included. LMWH combined with ASA treatment significantly improved the live birth rate (RR = 1.31, 95% CI: [1.19, 1.45], P < .00001), the rate of preterm stillbirths (RR = 0.23, 95% CI: [0.13, 0.40], P < .00001), rate of term delivery (RR = 1.55, 95% CI: [1.43, 1.67], P < .00001), rate of miscarriage (RR = 0.42, 95% CI: [0.36, 0.48], P < .00001), incidence of petechiae (RR = 0.44, 95% CI: [0.26, 0.72], P = .001), and incidence of thrombocytopenia (RR = 0.61, 95% CI: [0.39, 0.96], P = .03). In contrast, the incidence of preterm live births (RR = 1.07, 95% CI: [0.90, 1.28], P = .44), adverse reactions (RR = 0.77, 95% CI: [0.59, 1.00], P = .05), gingival bleeding (RR = 1.12, 95% CI: [0.65, 1.93], P = .69), and gastrointestinal reactions (RR = 0.87, 95% CI: [0.64, 1.17], P = .35) were not significant.

Conclusion:
LMWH combined with ASA treatment might improve pregnancy outcomes and reduces the incidence of adverse events in patients with RSA.
Post-craniopharyngioma surgery hypocalcemia due to denosumab use for osteoporosis: A case report
Authors: Jia Liangliang , Hu Yueqin , Jin Guilan 
Published: September 2024

Rationale:
Denosumab, a fully humanized IgG monoclonal antibody, is commonly employed in the management of different types of osteoporosis. Up to now, hypocalcemia linked with denosumab has been predominantly reported in dialysis patients suffering from chronic kidney disease. Interestingly, there have been no reports of hypocalcemia following craniopharyngioma surgery with the use of denosumab.

Patient concerns:
A 65-year-old male received a subcutaneous injection of denosumab (60 mg) as a treatment for osteoporosis following the resection of a craniopharyngioma. Remarkably, the patient developed hypocalcemia within 4 days post-injection. However, 6 months subsequent to the initial treatment, the patient underwent another subcutaneous injection of desmuzumab and once again experienced hypocalcemia.

Diagnoses:
Hypocalcemia.

Interventions:
The hypocalcemia was successfully managed with intravenous calcium gluconate and oral calcium carbonate D3 tablets, leading to the alleviation of symptoms.

Outcomes:
Hypocalcemia following the use of denosumab after craniopharyngioma surgery is rare, and its occurrence may be associated with the primary disease and concomitant medications.

Lessons:
It underscores the necessity for clinicians to perform a thorough evaluation of the patient’s overall health status, complete all requisite testing, pay particular attention to those in high-risk categories, and ensure serum calcium levels are monitored, along with conducting other essential tests, prior to and following each administration of denosumab.
Different surgical interventions for unstable intertrochanteric fracture of the femur: Network meta-analysis
Authors: Zhou Yuqiao , Zhang Xiufang , Wei Yun , Xu Yuhao , Feng Min , Wang Chunlin 
Published: September 2024

Objective:
Although a large body of evidence has reported on surgical approaches for the treatment of unstable intertrochanteric femoral fractures, studies that comprehensively evaluate treatment outcomes are limited. The purpose of this study was to compare the effectiveness of extramedullary fixation (i.e., dynamic hip screw [DHS]), intramedullary fixation (i.e., the proximal femoral nailing [PFN]), and hemiarthroplasty (HA) for the treatment of unstable intertrochanteric femoral fractures using network meta-analysis.

Methods:
This study meets the preferred reporting items for systematic reviews and meta-analyses criteria. The Patient, Intervention, Comparison and Outcome search protocol framework was used to search the Google Scholar, PubMed, Embase, and Cochrane Library databases were searched from inception until June 2023.

Results:
A total of 15 randomized controlled trials, including 1282 patients were analyzed. The Harris hip score (HHS) after DHS fixation was the lowest compared with that of PFN fixation and HA. DHS fixation had a significantly longer operation time than that of PFN fixation. Compared with HA, a lower incidence of superficial wound infection was observed with PFN and DHS fixations. PFN was significantly more likely to be implant cut out compared with HA. Compared with DHS, PFN and HA showed a lower incidence of fracture healing malunion.

Conclusion:
HA and PFN have good efficacy in improving the HHS and preventing joint deformities. However, HA showed a higher incidence of superficial infection than that observed with PFN, whereas a higher risk of screw cutout is observed with PFN than with HA.
Generative Artificial Intelligence
Authors: Hawk Heather , Coriasco Michael , Jones Jeffrey R. 
Published: September 2024

Background:
Understanding the functionality, benefits, and limitations of generative artificial intelligence (GAI) is important for nurses and nursing students.

Purpose:
This study explored nursing students’ perspectives on GAI after a guided learning activity in which students used a chatbot to answer a clinical question.

Methods:
A qualitative approach using reflective thematic analysis of written reflections was conducted with 19 nursing students in a nursing baccalaureate completion program.

Results:
Student reflections demonstrated 4 themes: surprisingly familiar; the importance of critical thinking and external validation; a good summary lacking depth and nuance; and cautious optimism. Two subthemes were also identified: validation is time-consuming and a new perspective.

Conclusions:
Learning activities using GAI influence students’ knowledge and attitudes and instill critical awareness of the advantages and limitations of this technology. Additional emphasis on bias in GAI is needed when teaching about AI.
360° Video Simulation Scenario for the WHO Global Patient Safety Challenge “Medication Without Harm”
Authors: Sousa Vitória Talya Dos Santos , Fernandes Ellen da Silva , Costa Edmara Chaves , Moura Jose Ricardo Sousa Ayres de , Melo Emanuella Silva Joventino , Carvalho Rhanna Emanuela Fontenele Lima de , Ríos Manuel Pardo , Vasconcelos Patrícia Freire de 
Published: September 2024

Background:
High-quality video productions integrating 360° simulations of real-life nursing scenarios, though still emerging and relatively rare, have shown promise in enriching learning experiences and refining students’ competencies, attitudes, and knowledge.

Purpose:
To develop a 360° video simulation scenario for teaching medication safety in nursing.

Methods:
The methodological framework comprised 3 key stages: (1) crafting the script; (2) scrutinizing the script’s validity through evaluation by expert judges in medication administration; and (3) developing the set, filming scenes, and refining the video using a 360° camera.

Results:
All evaluated elements garnered substantial concurrence among the expert panel. After script validation, the video script underwent refinement and validation by expert judges. The 360° video was tailored for utilization with virtual reality glasses, rendering it accessible for integration into nursing education curricula.

Conclusions:
The final version consisted of a continuous scene that ended with a question that prompted the identification of errors.
A pilot study of South African oncology pharmacy facilities: Comparison with best practice guidelines
Authors: Botha Ruan , Nelson Gill , Brouwer Derk 
Published: September 2024

Abstract

Introduction:
Exposure to antineoplastic drugs can lead to adverse health effects such as fetal loss and DNA damage. Oncology pharmacy facilities should implement best pharmacy practice guidelines to protect pharmacy personnel. The objective of this study was to assess South African oncology pharmacy facility workplace and personnel work practices, guided by internationally accepted best practice guidelines.

Methods:
A cross-sectional pilot study was conducted in 6 oncology pharmacy facilities (one personnel member per facility) of 2 South African oncology pharmacy service providers. Using a simple checklist, comprising 7 assessment categories and 43 questions derived from best practice guidelines, work and workplace practices were scored as compliant, partially compliant, or noncompliant. Each facility and service provider were also given an overall score.

Results:
Overall scores for the 6 facilities ranged from 33.1% to 79.3%. Service provider 2 pharmacy facilities (which were assessed as being compliant overall) scored higher at 78.0% ± 1.5 (76.4%–79.3%) than service provider 1 pharmacy facilities, which were noncompliant overall at 40.2% ± 21.5 (33.1%–49.9%). Categories in which performance was poor included the presence of engineering controls, use of personal protective equipment, and medical monitoring.

Conclusion:
The complexities of South African oncology pharmacy facilities highlight the need for stricter regulation. Despite operating under the auspices of managed care organizations, some facilities' work practices were poor. It is recommended that service providers implement international best practice guidelines.
Qualitative Research on the Causes of Kinesiophobia in Postoperative Cerebellar Tumor Patients
Authors: Xu Xin , Wang Wei , Feng Xiuqin 
Published: September 2024

Objective:
To understand the causes of kinesiophobia in postoperative patients with cerebellar tumors, and to provide the basis for early rehabilitation regimen.

Methods:
Using the objective sampling method, 16 postoperative cerebellar tumor patients were extracted for semi-structured interviews. Data was analyzed using the Colaizzi 7-step method, and the theme was refined.

Results:
The causes of kinesiophobia in postoperative cerebellar tumor patients were summarized into 4 themes: Excessive vigilance to self-state. Increased pain sensitivity and fear of dizziness were regarded as threat signals, which brought excessive burden on the current therapeutic regimen. Uncertainty of early rehabilitation. Lack of cognition, uncertainty effect of early rehabilitation, and insufficient exercise of self-efficacy. Psychological stress and avoidant emotion. Economic pressure and avoidant emotion ran out of control. Vulnerable support system. Deficient in professional technique, family, and social support.

Conclusion:
The kinesiophobia in postoperative cerebellar tumor patients is composed of multiple factors. Medical staff are supposed to help patients establish a correct perception of disease status. The information on early rehabilitation needs to be transmitted continually. To promote patients to participate in early rehabilitation activities energetically, it is vital to keep a high level of rehabilitation effect expectation, increased self-exercise efficiency, psychological intervention, and strong multi-party cooperation in an improved social support system.
Impact Assessment of the “4+1 Nursing Operation Mode” on Enhancing the Efficacy of Alveolar Surgery Diagnosis and Treatment
Authors: Yin Tingting , Sun Huan , Tang Rong , Li Qiaowen , Zheng Jin , Feng Yi , Wang Li 
Published: September 2024

Objective:
The aim of this study is to evaluate the impact of the “4+1 Nursing Operation Mode” on improving the efficacy of alveolar surgery and the effectiveness of nursing.

Methods:
A total of 200 patients were recruited from the oral and maxillofacial surgery outpatient department at the School and Hospital of Stomatology, Wuhan University, between November and December 2023. These patients were allocated into 2 groups: a control group and an experimental group. The treatment for these groups involved different combinations of physicians and nurses, including doctors A and B, and nurses A, B, and C. In November 2023, doctor A treated 50 patients with the assistance of nurses A and C under the “4+1 Nursing Operation Mode,” while another 50 patients were treated by doctor A with the assistance of nurse A following the “Four-Handed Operation Mode.” In December 2023, doctor B treated 50 patients with the assistance of nurse B under the “Four-Handed Operation Mode,” and another 50 patients were treated by doctor B with the assistance of nurses B and C using the “4+1 Nursing Operation Mode.” Patient visit durations were documented, and patient satisfaction with diagnostic and treatment services was evaluated via a questionnaire survey.

Results:
In comparison to the “Four-Handed Operation Mode,” the “4+1 Nursing Operation Mode” resulted in a 27% reduction in patient visit times and an improvement in patient satisfaction with nursing services.

Conclusions:
The “4+1 Nursing Operation Mode” surpasses the “Four-Handed Operation Mode” in terms of efficiency. It not only reduces patient visit times and enhances doctor work efficiency but also improves patient satisfaction with nursing services.
Assessment of the Correlation Between Types of Orbital Fractures and Ocular Symptoms, and the Effect of Manual Preformed and Patient-Specific Mesh Implants: A Retrospective Study
Authors: Zhao Zhihao , Guo Zeyou , Hu Wenzhong , Long Jie 
Published: September 2024

Objective:
Although certain orbital fractures are associated with specific clinical symptoms, these relationships should be reviewed comprehensively. The optimal choice between manual preformed mesh implants (MPIs) and patient-specific mesh implants (PSIs) for orbital reconstruction remains undetermined due to inconclusive evidence regarding their effectiveness.

Methods:
This retrospective study investigated 280 patients with unilateral orbital fractures to explore the correlation between clinical ocular symptoms, including diplopia, enophthalmos, limitation of ocular movement, blindness, and the specific type of orbital fracture. The effects on orbital volume (OV) and orbital volume ratio (OVR) of MPI and PSI with and without the use of navigation were also evaluated in this study. Patients were categorized into 4 groups: MPI, PSI, navigation-assisted MPI, and navigation-assisted PSI. After this categorization, alterations in OV and OVR were analyzed before and after surgical intervention.

Results:
Significant correlations were observed between the orbital fracture type and diplopia, enophthalmos, and limitation of ocular movement (P < 0.05). Patients in the MPI group exhibited a notable difference in the postoperative OV between the injured and normal sides (P < 0.05), but no statistically significant difference was found in the postoperative OV between the injured and normal sides among the patients in the other 3 groups (P > 0.05). Moreover, the MPI group demonstrated significantly higher postoperative OVR than the other groups (P < 0.05). Notably, PSI remained effective with or without navigation, MPI combined with navigation technology achieved a reconstruction quality similar to that of PSI by rectifying positioning errors during surgery.

Conclusion:
The authors found significant correlations (P < 0.05) between orbital fracture type and diplopia, enophthalmos, and limitations of ocular movement. Patient-specific mesh implant plays an important role in orbital reconstruction. It is also a good method for reconstructing orbital fractures using MPI assisted by navigation technology.
Poor Prognostic Factors in Long-Term Survivors of Resected Pancreatic Ductal Adenocarcinoma
Authors: Javed Ammar A. , Rompen Ingmar F. , van Goor Iris W.J.M. , Stoop Thomas F. , Andel Paul , Mahmud Omar , Fatimi Asad Saulat , Habib Joseph R. , Mughal Nabiha A. , Schouten Thijs , Lafaro Kelly , Burkhart Richard A. , Burns William R. , Santvoort Hjalmar C. van , Dulk Marcel den , Daams Freek , Mieog J. Sven D , Stommel Martijn W. J. , Patijn Gijs A. , Hingh Ignace de , Festen Sebastiaan , Nijkamp Maarten W. , Klaase Joost M. , Lips Daan J. , Wijsman Jan H. , Harst Erwin van der , Manusama Eric , Eijck Casper H J van , Koerkamp Bas Groot , Kazemier Geert , Busch Olivier R. , Molenaar I. Quintus , Daamen Lois A. , He Jin , Wolfgang Christopher L. , Besselink Marc G. ,   for the Dutch Pancreatic Cancer Group and the PANC-PALS Consortium
Published: September 2024

Objective:
To measure the rate of LTS in resected PDAC and determine the association between predictors of OS and LTS.

Summary Background Data:
Long-term survival (>5 y, LTS) remains rare in pancreatic ductal adenocarcinoma (PDAC). Multiple predictors of overall survival (OS) are known but their association with LTS remains unclear.

Methods:
An international, multicenter retrospective study was conducted. Included were patients from 2012-2019 with resected PDAC. Excluded were those with metastases at diagnosis or resection, R2 resections, and 90-day mortality. Predictors of OS were identified using multivariable Cox regression and their prevalence in patients with LTS assessed. LTS was calculated by excluding patients with shorter follow-up and predictors of LTS were identified using multivariable logistic regression.

Results:
3,003 patients were included (27.4% received neoadjuvant chemotherapy). Elevated baseline CA19-9, high tumor grade, nodal disease, and perineural and lymphovascular invasion were negative independent predictors of OS, while receipt of adjuvant chemotherapy predicted improved OS (all P<0.05). LTS was observed in 220/2,436 patients (9.0%), of whom 198 (90%) harbored poor prognostic factors: elevated baseline CA19-9 (58.1%), poor tumor differentiation (51.0%), nodal disease (46.8%), and perineural invasion (76.0%). Of those without any of these four features, 50.0% achieved LTS as compared to 21.3%, 13.3%, 5.2%, and 3.5% in those with 1, 2, 3, or 4 features.

Conclusions:
This bi-national cohort demonstrates a true LTS rate of 9.0% in resected PDAC. Clinicians should remain aware that presence of poor prognostic factors does not preclude LTS.