bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laser interstitial thermal therapy for hypothalamic-hamartoma-related epilepsy: the long-term cognitive outcome of the first pediatric case in Europe
Authors: Diab Eva , LEFRANC M , MOING Anne Gaelle LE , HERY Loic , BOUREL-PONCHEL Emilie , BERQUIN Patrick 
Published: September 2024

Abstract

Laser interstitial thermal therapy (LITT) is a minimally invasive surgical treatment for drug-resistant, focal epilepsies. With MRI guidance, LITT can also be used to treat hypothalamic hamartoma. Here, we report on the first European case of LITT for hypothalamic hamartoma. No complication occurred except a transitory peripheral facial paralysis. The short- and long term outcomes (for both epilepsy and cognitive development) were excellent.
Association between Preoperative Exercise Tolerance and Unplanned Readmission in Patients with Pancreatic Cancer: A Retrospective Analysis
Authors: Onji Makoto , Nakai Asuka , Kakizoe Shinji , Naito Koichi , Kozono Shingo 
Published: September 2024

Abstract

Background
This study aimed to investigate the relationship between preoperative exercise tolerance and the likelihood of unplanned readmission in patients with pancreatic cancer. Despite advances in treatment, the incidence of postoperative complications following pancreatectomy remains high, leading to frequent hospital readmissions.
Methods
This retrospective analysis included 133 patients who underwent pancreatectomy between July 2019 and September 2022 and their preoperative exercise tolerance was assessed using the 6-min walk distance (6 MWD).
Results
The study found a 23.4% readmission rate within 1 year, with the median 6 MWD being significantly lower in readmitted patients than in those who were not readmitted (390.0 m versus 438.5 m; p < 0.01). A 6 MWD cut-off of 425 m was a strong predictor of readmission, with lower preoperative exercise tolerance associated with a higher risk of readmission.
Conclusions
Enhancing preoperative physical reserves through exercise therapy may reduce readmission rates and improve patient outcomes. Further research with larger sample sizes is required to confirm these findings.
Does timely surgery or not affect surgical outcomes in patients with severe spinal tuberculous kyphosis? An observational cohort study
Authors: Gao Yuan , Zhao Jianquan , Lai Bowen , Zhang Zhanrong , Jiang Heng , Zhou Xuhui 
Published: September 2024

Abstract

Background Spinal tuberculous kyphosis can cause paralysis, severely affecting patient's life. However, timing of the surgery has become a controversial issue. The aim of this study was to explore whether timely surgery would have an impact on surgical outcomes. Methods In this single-center, retrospective, observational cohort study, we collected clinical data of patients with severe spinal tuberculous kyphosis who underwent surgery from July 1st, 2015 to February 28th, 2019 at Shanghai Changzheng Hospital. We obtained patients' consultation, treatment, and follow-up data from the patient database of Shanghai Changzheng Hospital, and divided them into two groups according to whether they received surgery timely. We compared the data of the two groups using neurological function recovery as the primary outcome indicator and complication rates and deformity correction rates as the secondary outcome indicators. Results A total of 43 patients were included. 48.8% patients underwent surgery within 2 years and all patients underwent surgery within 7 years after the neurological symptoms onset. We grouped the patients who were treated surgically after 2 years as non-timely surgery group (Group A, Number of cases: 22) and the patients who were treated within 2 years as timely surgery group (Group B, Number of cases: 21). There was no statistically significant difference in correction rates between the two groups. There was a statistical difference in pulmonary complication rates (P = 0.037) and follow-up neurological function recovery rates (P = 0.021). Conclusion Considering neurological function recovery, deformity correction and complications, we support that patients with severe spinal tuberculous kyphosis should receive surgical treatment as soon as possible after the neurological symptoms onset and preferably within 2 years. This contributes to postoperative neurological recovery in patients as well as reducing the incidence of pulmonary complications.
A two-person collaborative conservative repositioning approach successfully reduced peritoneal dialysis catheter high migration: A case report and literature review
Authors: Yao Zhuangyan , Li Yanqing , Zhai Liping 
Published: September 2024

Abstract

Peritoneal dialysis catheter displacement is one of the most common complications in peritoneal dialysis patients, with serious consequences such as poor dialysate drainage, infection, and abdominal pain. Therefore, timely and effective treatment of catheter displacement is essential to maintain the patient's dialysis treatment. This case report describes catheter migration in an 80-year-old female peritoneal dialysis patient and details the successful reduction of the catheter by a two-person collaborative conservative reduction approach. Compared with other surgical and conservative reduction methods, this method not only reduces the physical and mental burden of elderly patients, but also has better results, significantly improves the success rate of reduction, and shortens the reduction time. In addition, this method effectively reduces the economic cost, is simple to operate, has high safety, and is easy to be accepted by patients. This case shows that this method has a significant effect in elderly patients and improves the quality of peritoneal dialysis, which is worthy of further promotion and application in clinical practice.
Adverse reactions associated with the use of ustekinumab in Crohn's disease treatment：an analysis based on the FAERS database
Authors: Guo Chiwei , Kang Qile , Lei Da , Mei Xuejiao , Wu Xingmei , Si Yifan , Wang Nongrong 
Published: September 2024

Abstract

Background: Approved in 2016 for Crohn’s disease(CD), ustekinumab’s adverse reaction signals(ADRs) remain largely unclear. This study aims to enhance clinical safety by identifying ADRs through mining the FAERS database.
Methods: We collected adverse drug event (ADE) data for ustekinumab used in the treatment of CD, reported in the FDA’s Adverse Event Reporting System from the fourth quarter of 2016 to 2023. For signal mining, we employed the Reported Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Belief Propagation Neural Network (BCPNN), and Empirical Bayesian Geometric Mean (EBGM). Additionally, we conducted a statistical classification of ADRs according to the System Organ Class (SOC).
Results: The timeframe was limited to Q4 2016 to Q4 2023. For CD, 17,187 ADRs were identified, resulting in 44,232 signals affecting 24 SOCs and 258 PTs. The most numerous reports were for injury, poisoning, and procedural complications. Infections and infestations had the highest ROR signals. Among PTs, congenital pulmonary airway malformation had the strongest ROR signal and the highest off-label use instances.
Conclusion: When administering ustekinumab for CD, in addition to monitoring common AEs like infections and tumors, vigilance is crucial for potential AEs involving the heart, hepatobiliary system, and emerging genetic diseases.
Association of CU/ZN Ratio With Protein Energy Wasting, Inflammation and Cardiovascular Disease Susceptibility of Patients Undergoing Hemodialysis
Authors: Fikadu Henok Akalu , Juhar Leja Hamza , Assefa Eskedar Getachew 
Published: September 2024

Abstract

End-stage renal disease (ESRD) presents a significant global health challenge, with hemodialysis (HD) being the primary treatment option. HD patients are prone to complications such as protein-energy wasting (PEW), inflammation, and cardiovascular disease (CVD). The imbalance in the ratio of copper (Cu) to zinc (Zn) has been implicated in the development and progression of these conditions. However, little is known about the association between the Cu/Zn ratio and these metabolic parameters in Ethiopian hemodialysis patients. This study aimed to evaluate the association of the Cu/Zn ratio with protein-energy wasting, inflammation, and CVD susceptibility in hemodialysis patients at St. Paul Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia. A cross-sectional study was conducted for three months, involving 42 hemodialysis patients and 20 healthy individuals as controls. Serum Cu and Zn levels were measured using inductively coupled plasma mass spectroscopy (ICP-MS), and the Cu/Zn ratio was calculated. PEW was assessed through anthropometric measurements and biochemical markers. Inflammation levels were determined using C-reactive protein (CRP) while CVD risk factors were evaluated. The correlation between the Cu/Zn ratio and markers of PEW, inflammation, and CVD risk factors in hemodialysis patients was examined. The Statistical Package for Social Science (IBM SPSS version 20) was used for the data analysis. The study revealed that most hemodialysis patients (64.2%) exhibited an elevated Cu/Zn ratio compared to healthy controls. The Cu/Zn ratio showed a significant inverse correlation with serum albumin levels and triceps skinfold thickness and CRP indicating a relationship with PEW and Inflammation. Furthermore, a moderate positive correlation was observed between the Cu/Zn ratio and basal systolic blood pressure, a well-known CVD risk factor. Hemodialysis patients demonstrated an elevated Cu/Zn ratio, associated with PEW, inflammation, and increased cardiovascular disease risk factors. Monitoring and managing these imbalances are crucial for improving hemodialysis patients' health outcomes.
Application of Terahertz Time-Domain Spectroscopy in the Protection of Color Cultural Relics
Authors: Yanhong Liu , Kangyu Yang , Tianhua Meng 
Published: September 2024

Abstract

The identification of appropriate pigments for the conservation of cultural murals and sculptures continues to pose a significant challenge. In this paper, terahertz time-domain spectroscopy was utilized to distinguish the common heritage pigments. The terahertz time domain spectra, frequency domain spectra, transmission spectra, absorption spectra and refractive index of six pigments(garcinia, lapis, lazuli, loess, calcite, laterite, mineral green)with very different colors were analyzed and studied in the range 0.2 to 1.5THz. Furthermore, in order to demonstrate the applicability of terahertz time-domain spectroscopy more comprehensively, the terahertz spectra of garcinia and orpiment as well as laterite and sinopis with very similar colors were investigated and compared respectively. The experimental results show that indicate distinct differences in the spectral characteristics for each pigment. Additionally, evident differences in spectral characteristics were observed for pigments with the same main ingredients. These results suggest that terahertz measurement techniques can provide an accurate reference for restoring color to cultural relics.
Impaired metabotropic glutamate type 5 receptor signaling in the dorsal striatum of the R451C-neuroligin 3 mouse model of Autism Spectrum Disorder
Authors: Meringolo Maria , Montanari Martina , D'Antoni Simona , Martella Giuseppina , Atiallah Ilham El , Ponterio Giulia , Tassone Annalisa , Reverte Ingrid , Caprioli Daniele , Strimpakos Georgios , Pieroni Luisa , Catania Maria Vincenza , Bonsi Paola 
Published: September 2024

Abstract

Background Human genetics indicates enrichment of synaptic pathway-related mutations in Autism Spectrum Disorder (ASD). Accordingly, several preclinical studies have reported synaptic alterations in different brain areas of relevant ASD mouse models. In particular, we previously showed that corticostriatal long-term synaptic depression is impaired in the dorsal striatum of mice carrying the ASD-associated R451C mutation in the neuroligin3 gene.Methods We used behavioral, proteomic, biochemical, and electrophysiological approaches to explore the dorsal striatum-dependent functions in the R451C-neuroligin3 mouse model of ASD.Results A detailed behavioral analysis confirmed striatum-dependent alterations in these mice. We further explored the corticostriatal synaptic function, disclosing modifications of the glutamatergic postsynaptic density protein composition, which functionally result in the impairment of different forms of corticostriatal synaptic plasticity, namely activity-dependent long-term depression and potentiation, and group I metabotropic glutamate receptor-dependent synaptic depression. We also found reduced protein expression levels of type 5 metabotropic glutamate receptor at striatal synapses, which likely preclude the expression of long-term potentiation and depression by preventing the potentiation of NMDA receptor-mediated currents and a sufficient generation of endocannabinoids, respectively.Conclusions Overall, our findings point to a significant impairment of type 5 metabotropic glutamate receptor signaling, affecting the dorsal striatum function, which underlies specific autism-relevant behaviors in R451C-neuroligin3 mice.
Durable flame-retardant finishing of cotton fabric via constructing multiple crosslinked layers
Authors: Fan Zuwei , Xue Yihai , Liu Hao , Yu Yuanyuan , Liu Rangtong 
Published: September 2024

Abstract

To improve the flame-retardant performance of cotton fabric, multiple crosslinked layers were constructed on cotton fiber surfaces through polymerization of m-phenylenediamine (MPD)/tetrakis hydroxymethyl phosphonium chloride (THPC) and trimesoyl chloride (TMC). The resulting morphology, general properties, flame retardancy, and durability were characterized and analyzed. Cotton fabric alternately finished with MPD-TMC and THPC-TMC displayed greater changes in surface morphology than that finished with single crosslinked products. The former material had the highest weight gain percentage and possessed significantly higher limiting oxygen index (LOI) value and weaker heat release, accompanied by formation of a more robust carbonaceous layer during micro combustion calorimetry. After alternating finishing with MPD-TMC and THPC-TMC, the cotton fabric exhibited increased flexural rigidity and decreased air permeability, with the change influenced by the number of finishing cycles. Increased finishing cycles also resulted in an increased LOI, up to 33.5% after five cycles. According to micro combustion calorimetry results, heat release was suppressed more effectively as long as the number of finishing cycles reached three, such that finishing with 3 cycles was optimal in this study. Moreover, a fabric with 3 cycles of alternating finishing almost kept its LOI value after washing in disturbed water for 24 h, exhibiting good durability for flame retardancy, which would be beneficial in real applications.
A novel variant of NEMF in a family with congenital fibrosis of the extraocular muscles: a case report and literature review
Authors: Peng Chuzhi , Zhang Ranran , Jia Hongyan , Chang Qinglin , Wang Dan , Jiao Yonghong 
Published: September 2024

Abstract

Background
Congenital fibrosis of the extraocular muscles (CFEOM) is one of the congenital cranial dysinnervation disorders (CCDDs) characterized by hypoplastic oculomotor nerves (CN3), congenital ptosis and non-progressive restrictive ophthalmoplegia. The NEMF gene encodes a protein that resolves stalled ribosomes during translation. Variants in NEMF have been associated with neurodevelopmental and neuromuscular disorders, including intellectual disability, developmental delay, central nervous system impairment and peripheral neuropathy.
Case presentation:
We describe a family with CFEOM harboring a novel variant of NEMF gene. CFEOM3 was diagnosed in two siblings, a 9 year old girl and a 6 year old boy. Whole-exome sequencing (WES) revealed that the siblings carried a novel heterozygous NEMF variant c.1972A > C, p. (Lys658Gln). This variant was predicted to lead to the loss of hydrogen bonds, potentially affecting the spatial structure and stability of the NEMF protein.
Conclusions
Our findings support that the NEMF variant may be the cause of CFEOM in our case. This report expands the phenotypic spectrum of NEMF-associated diseases and provides a new candidate gene for CFEOM.
Investigation of the Free-Radical Polymerization of Vinyl Monomers Using Horseradish Peroxidase (HRP) Nanoflowers
Authors: Ozaydin Gulbahar , Mirioglu Muge , Dadi Seyma , Ocsoy Ismail , Gokturk Ersen 
Published: September 2024

Abstract

In this study, we report the production of flower-shaped HRP-Cu2+ hybrid nano biocatalyst from the complexation between horseradish peroxidase (HRP) enzyme and Cu2+ ions, and investigate catalytic activity and stability of the obtained nanoflowers on the polymerization of some vinyl monomers (styrene, methylmethacrylate, acrylamide and N-isopropylacrylamide). Polymerizations of these monomers, except water soluble acrylamide, were accomplished under emulsion conditions using cationic, anionic and non-ionic surfactants in the presence of H2O2 and 2,4-pentanedione mediator. Optimum polymerizations were achieved under the conditions of non-ionic surfactant (tween 40) used. HRP-Cu2+ mediated polymerizations resulted in very high yields and molecular weights (Mn) of the polymers. Optimum polymerization of styrene with 84% of yield (Mn= 319 kDa) was accomplished at room temperature. However, the highest polymerization yields for acrylamide (96%, Mn= 171 kDa) and N-isopropylacrylamide (85%, Mn= 185 kDa) was achieved at 70 ºC. Similarly, optimum polymerization of methylmethacrylate was accomplished with 84% of yield (Mn= 190 kDa) at 60 ºC. While free-HRP loses its catalytic activity at 60 ºC and above temperatures, HRP-Cu2+ showed very high catalytic activity and stability even at 70 ºC. Increasing activity and stability of hybrid nanoflowers provide significant advantages for both scientific and industrial applications.
How do original actions performed by an attacker modify defensive dispersion in small-sided soccer games?
Authors: Borges Paulo Henrique , Ueda Lucas Shoiti Carvalho , de Souza Paulo Vitor , Binda Maria Eduarda Valente , Silva Juliano Fernandes da , Ribeiro João , Guilherme José 
Published: September 2024

Abstract

In complex systems, the system’s self-regulation processes can transition between states of equilibrium and disequilibrium, leading to changes in the distribution of players within the playing space. Actions that are surprising, rare, or out of the ordinary tend to be valued for their potential to destabilize the opposing defensive structure, altering player dispersion, and creating fragile spaces for the attack. With advancements in understanding the influence of the environment on players' affordances, the tactical consequences from individuals' solutions to various scenarios and their impact on the game context becomes a rich area for investigation. This study compared defensive dispersion in the moments preceding and following original actions in small-sided games. The original actions were obtained using the Creative Behavior Assessment in Team Sports (CBATS) observational matrix. At the same time, defensive dispersion was derived from positional data collected via GPS and processed using dedicated routines in MATLAB to obtain variables such as Stretch Index, Surface Area, Team Width, Team Length, and Individual Player Area. The Kolmogorov-Smirnov test was employed for normality, and the General Linear Model with Repeated Measures was used to compare pre-and post-action moments across different action classifications (pass and shot) and game configurations (SSG4v4-Small, SSG4v4-Large, SSG5v5-Small, and SSG5v5-Large). Differences were found in the Stretch Index, Surface Area, and Team Width variables in SSG4v4-Small and Surface Area in SSG5v5-Small (p < 0.05). It was concluded that the original action could attract opponents in small formats of SSG, increasing the contraction of the opposing team and reducing space around the action, with the potential to create new spaces in other areas of the field.
Assessing the landscape of clinical trials involving bioprinting: a scoping review
Authors: Briones Yumi , Pascua Beatrice , Tiangco Narra , Crisostomo Isabel , Casiguran Samantha , Remenyi Roland 
Published: September 2024

Abstract

Objective:
Bioprinting is a tissue engineering technique that is rapidly evolving to include complex clinical applications. However, there is limited evidence describing how far bioprinting has progressed past the pre-clinical stage. Thus, we conducted a scoping review to assess the landscape of clinical trials involving bioprinting by charting trends in general characteristics, bioprinting application, and trial design.
Methods:
The term "bioprint" and its variants were searched in five trial databases (ICTRP, ScanMedicine, CENTRAL, NIHCC, HCCTD) and two registries (ClinicalTrials.gov, PHRR) on 22 February 2024. This was followed by duplicate removal and dual independent review to finalize the inclusion list. We included trials published in or translated to English mentioning "bioprint" in their design, while we excluded those that did not adhere to our definition of bioprinting. Finally, data were charted and synthesized narratively.
Results:
Of 36 total search records, 11 trials met inclusion criteria. Registration dates ranged from 2016 to 2023, with China conducting the most trials globally. Only one trial had published results while the majority were still in progress. Seven trials aimed to bioprint in vitro models with autologous cells to study patient-specific conditions such as cancer. The remaining four trials aimed to implant bioprinted tissues, also with autologous cells, including blood vessels, trachea, external ear, and wound dressings.
Conclusion:
Bioprinting is still in the early stages of clinical research, with a focus on producing patient-specific tissues for cancer precision medicine and regenerative purposes. More standardized reporting of bioprinting-related information is needed to improve communication between researchers. As the body of evidence grows, our review may be used as a framework to monitor the clinical translation of bioprinting over the years.
PROZ and ARNT genes novel homozygous mutations are related to Recurrent pregnancy loss
Authors: Komachali Sajad Rafiee , Salehi Mansoor , Tamandani Dor Mohammad Kordi 
Published: September 2024

Abstract

Background
Recurrent miscarriage or Recurrent pregnancy loss is a complex situation, defined by two, three or more pregnancy losses. Expression of PROZ and ARNT genes are vital in normal pregnancy and their partial or complete deficiencies will result in early pregnancy loss and also recurrent pregnancy losses. Present study aims to find PROZ and ARNT novel mutations as causes of Recurrent miscarriage; and involves two couples that they had a consanguineous marriage and referred with 3 Recurring miscarriages. To find out the cause, pathological tests were requested for fetus and high resolution giemsa banding karyotypes were requested for couple. Also product of abortion sampling was done for array CGH and whole-exome sequencing in order to mutation analysis. It is notable that sanger sequencing was done for confirming the mutation.
Results
Based on the results, our first proband has novel likely pathogenic homozygous mutation NM_003891:c.349T > C (p.Y117H) in PROZ gene locates on 13q34 as a novel mutation of the PROZ gene, and our second proband has novel likely pathogenic homozygous mutation NM_001286035:exon16:c.1353-2A > G in ARNT gene, locates on 1q21.3. Sanger sequencing confirmed homozygosity of these two mutations in the probands and heterozygosity of these loci in their parents, suggesting it as the likely pathogen mutations, and autosomal recessive inheritance pattern in Recurrent miscarriage.
Conclusion
Novel likely pathogenic homozygous mutation NM_003891:c.349T > C (p.Y117H) in PROZ gene, and novel likely pathogenic homozygous mutation in ARNT gene are related to Recurrent miscarriage.