bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma Concentrations of Afamin Are Associated With Prevalent and Incident Type 2 Diabetes: A Pooled Analysis in More Than 20,000 Individuals
Authors: Kollerits Barbara , Lamina Claudia , Huth Cornelia , Marques-Vidal Pedro , Kiechl Stefan , Seppälä Ilkka , Cooper Jackie , Hunt Steven C. , Meisinger Christa , Herder Christian , Kedenko Ludmilla , Willeit Johann , Thorand Barbara , Dähnhardt Doreen , Stöckl Doris , Willeit Karin , Roden Michael , Rathmann Wolfgang , Paulweber Bernhard , Peters Annette , Kähönen Mika , Lehtimäki Terho , Raitakari Olli T. , Humphries Steve E. , Vollenweider Peter , Dieplinger Hans , Kronenberg Florian 
Published: September 2017

OBJECTIVE
The human vitamin E–binding glycoprotein afamin is primarily expressed in the liver and has been associated with prevalent and incident metabolic syndrome. These data were in line with observations in transgenic mice. We thus investigated whether afamin concentrations are associated with prediabetes, type 2 diabetes, and insulin resistance (IR).

RESEARCH DESIGN AND METHODS
Individual-level baseline (n = 20,136) and follow-up data (n = 14,017) of eight prospective cohort studies were investigated. Study-level data were combined using random-effects meta-analyses. Main outcomes were prevalent and incident type 2 diabetes, prediabetes, and IR. Discrimination and reclassification of participants was analyzed for incident type 2 diabetes.

RESULTS
Mean afamin concentrations between studies ranged from 61 to 73 mg/L. The eight studies included 1,398 prevalent and 585 incident cases of type 2 diabetes. Each increase of afamin by 10 mg/L was associated with prevalent type 2 diabetes (odds ratio [OR] 1.19 [95% CI 1.12–1.26], P = 5.96 × 10−8). Afamin was positively associated with IR assessed by HOMA-IR (β 0.110 [95% CI 0.089–0.132], P = 1.37 × 10−23). Most importantly, afamin measured at baseline was an independent predictor for 585 incident cases of type 2 diabetes (OR 1.30 [95% CI 1.23–1.38], P = 3.53 × 10−19) and showed a significant and valuable gain in risk classification accuracy when added to this extended adjustment model.

CONCLUSIONS
This pooled analysis in &gt;20,000 individuals showed that afamin is strongly associated with IR, prevalence, and incidence of type 2 diabetes independent of major metabolic risk factors or parameters. Afamin might be a promising novel marker for the identification of individuals at high risk for the development of type 2 diabetes.
EFECTO DE LAS CONDICIONES DE ALMACENAMIENTO EN LA DEGRADACIÓN DE CIPERMETRINA EN PASTOS EN CLIMA FRIO MODERADO
Authors: Cardona Yaneth , Peláez Manuel , Chaparro Amanda 
Published: September 2017

Para mantener la integridad de las muestras durante las determinaciones analíticas, es importante controlar la manipulación y preservación de las mismas,pues no es común realizar los análisis in situ; por lo cual, las muestras deben sertransportadas a un laboratorio antes de su análisis. Diferentes factores contribuyen a la inestabilidad de los pesticidas piretroides, como la composición de la matriz,material del recipiente de almacenamiento, acidez de la muestra, entre otros. El objetivo de este trabajo fue determinar las condiciones adecuadas de almacenamiento de tres tipos de pasto (Pennisetum clandestinum, Brachiaria decumbens y Cynodon nlemfuensis ), que garanticen la integridad de la cipermetrina en estas muestras. Se compararon cuatro tipos de recipientes y ocho condiciones diferentes de almacenamiento, utilizando microextracción en fase sólida (SPME) y cromatografía de gases con detector de ionización de llama (GCFID) como técnicas deextracción y determinación,para estudiar la degradación de cipermetrina. Se encontró que las muestras de forraje estudiadas se pueden almacenar durante cinco días previos al análisis, en bolsas de polietileno de alta densidad o aluminio, en la nevera a una temperatura entre 5°C y -4°C.
SOBRE LA INTEGRAL DE CAMINO EN EL ESPACIO DE FASE DE UNA PARTÍCULA EN UN CAMPO MAGNÉTICO CONSTANTE
Authors: Villamizar Villamizar Adolfo , Becerra Becerra. Ariel 
Published: September 2017

El movimiento de una partícula cargada en un campo magnético constante es analizado por medio de la integral de camino en del espacio fase. Para encontrar el propagador, la acción es expresada en términos del espacio fase y el campo magnético es expresado como el rotacional de un vector potencial que satisface la condición gauge de Coulomb para un campo magnético. Se obtiene la expresión del oscilador armónico unidimensional como expresión matemática que describe el comportamiento de la partícula cargada en el campo magnético constante. Se muestra que el vector potencial tiene un rol fundamental en la simplificación de este resultado. Palabras clave: integral de camino, partícula en campo magnético, propagador, espacio de fase.
Auditing the Systems Understanding Aid Project: An Integrative Assignment for Accounting Students
Authors: Swanger Susan L. , Jones Beth H. 
Published: September 2017

ABSTRACT
Accounting educators strive to prepare graduates for work in their chosen field. Various teaching methods can be employed to best accomplish this goal. One valuable tool is the use of active learning tasks that simulate external work environments. This paper describes the collaboration between an AIS and an Auditing professor who used an integrative task that spanned their two classes over two semesters. The authors had their AIS students complete Arens and Ward's Systems Understanding Aid (SUA) project (Arens & Ward, 2008). The following semester, students in the auditing class audited the records and financials that had been generated by students the previous semester. The project was designed to facilitate course integration and teamwork by having groups of students play the role of corporate accountants, then act as independent auditors.
Patrimoine sans limite ? La mondialisation du tourisme comme opérateur d’un « tout-patrimoine »
Authors: Coëffé Vincent , Morice Jean-René 
Published: September 2017

Le champ de la mémoire est marqué depuis les années 1970 notamment par une « inflation patrimoniale ». Cet article vise à montrer comment le tourisme, à travers sa mondialisation, constitue non seulement un opérateur de la patrimonialisation, mais aussi de l’élargissement du champ patrimonial. Le phénomène touristique, à travers les touristes notamment, est régulièrement saisi comme une menace pour le patrimoine. Or, les acteurs investis dans le tourisme ont en réalité largement contribué à inventer le « monument historique » et continuent d’inventer de « nouveaux patrimoines ». Pour autant, la dynamique de co-constitution du tourisme et du « tout-patrimoine » reste lacunaire, et la patrimonialisation peut même constituer un enjeu pour la « dé-touristification ».
Arts, mémoires et engagement au Drill Hall (Johannesburg) : l’invention d’un patrimoine incertain
Authors: Guinard Pauline , Morovich Barbara 
Published: September 2017

Site patrimonial du centre-ville de Johannesburg (Afrique du Sud), le Drill Hall est peu entretenu par les institutions publiques mais fortement approprié par des associations artistiques, culturelles et sociales. Dans cette tension entre une patrimonialisation institutionnelle faible et la vivacité des mémoires, ce lieu apparaît comme un espace interstitiel en attente de son destin institutionnel. En quoi, les artistes correspondent-ils à des figures de l’engagement ? Dans quelle mesure les discours des artistes constituent-ils un vecteur de patrimonialisation et un argument de légitimation de leur présence ? Nous montrerons que cet engagement artistique et mémoriel contribue à l’invention d’un rapport inédit à l’art et au patrimoine, mais dont la capacité de résistance aux projets de rénovations urbaines et plus encore à la gentrification est pour le moins incertaine.
Arabie Saoudite : la guerre des trois n’a pas eu lieu
Authors: Paul Jacques-Jocelyn 
Published: September 2017

La « saoudité » reste difficile à définir, et elle suggère à la fois un type de débat politique très spécifique et la peur profonde d’une implosion immaîtrisable. C’est dans ce cadre que s’inscrit la relation conflictuelle avec le Qatar, représentant pour Riyad une idéologie des Frères musulmans antagonique avec ses propres conceptions. La modification de l’ordre de succession royal entérine un saut de génération, et un printemps arabe ne semble pas devoir toucher prochainement Riyad.
Refractive Outcomes of 20 Eyes Undergoing ICL Implantation for Correction of Hyperopic Astigmatism
Authors: Coskunseven Efekan , Kavadarli Isilay , Sahin Onurcan , Kayhan Belma , Pallikaris Ioannis 
Published: September 2017

PURPOSE:
To analyze 1-week, 1-month, and 12-month postoperative refractive outcomes of eyes that under-went ICL implantation to correct hyperopic astigmatism.

METHODS:
The study enrolled 20 eyes of patients with an average age of 32 years (range: 21 to 40 years). The outcomes of spherical and cylindrical refraction, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), vault, and angle parameters were evaluated 1 week, 1 month, and 12 months postoperatively.

RESULTS:

The preoperative mean UDVA was 0.15 ± 0.11 (decimal) (20/133 Snellen) and increased to 0.74 ± 0.25 (20/27 Snellen) postoperatively, with a change of 0.59 (decimal) (20/33.9 Snellen) (
P
< .0001), which was statistically significant. The preoperative mean CDVA was 0.74 ± 0.25 (decimal) (20/27 Snellen) and increased to 0.78 ± 0.21 (20/25 Snellen), with a change of 0.03 (decimal) (20/666 Snellen) (
P
< .052), which was not statistically significant. The mean preoperative sphere was 6.86 ± 1.77 diopters (D) and the mean preoperative cylinder was −1.44 ± 0.88 D. The mean 12-month postoperative sphere decreased to 0.46 ± 0.89 D (
P
< .001) and cylinder decreased to −0.61 ± 0.46 D (
P
< .001), with a change of 6.40 D, both of which were statistically significant. The mean 1-month postoperative vault was 0.65 ± 0.13 mm and decreased to 0.613 ± 0.10 mm at 1 year postoperatively, with a change of 0.44 mm (
P
< .003). The preoperative/12-month and 1-month/12-month trabecular–iris angle (TIA), trabecular–iris space area 500 mm from the scleral spur (TISA500), and angle opening distance 500 mm from the scleral spur (AOD500) values were analyzed nasally, temporally, and inferiorly. All differences were statistically significant between preoperative/12-month analysis. The only differences between 1- and 12-month analysis were on TISA500 inferior (
P
< .002) and AOD500 nasal (0.031) values.

CONCLUSIONS:
ICL hyperopic toric implantation is a safe method and provides stable refractive outcomes in patients with high hyperopia (up to 10.00 D) and astigmatism (up to 6.00 D).

[
J Refract Surg.
2017;33(9):604–609.]
Temperature-manipulated dynamics and phenology ofMindarus abietinus(Hemiptera: Aphididae) in commercial Christmas tree plantations in Québec, Canada
Authors: Doherty Jean-François , Guay Jean-Frédéric , Cloutier Conrad 
Published: September 2017

AbstractThe balsam twig aphidMindarus abietinusKoch (Hemiptera: Aphididae) is a major pest of economic importance for the Christmas tree industry. Global warming during the 21st century could potentially increase local population densities and reinforce the pest status of this aphid in commercial fir (AbiesMiller; Pinaceae) plantations in Québec, Canada. During this study, we tested the effects of a warmer environment on colony growth rates ofM. abietinusand aphid morph composition during the second generation of its cycle, which is key to colony size growth and potential damage to Christmas trees. We monitoredM. abietinuspopulations on two host fir species and one host fir variety, in order to understand the early season dynamics of this aphid and its host tree. It was possible to distinguish the two overlapping generations of winged aphids leaving colonies, which led to observing a much higher proportion of wingless daughters, produced by the stem mother, than what had previously been reported. Colony growth rates were significantly higher in a warmer environment than in the nearby plantation, suggesting that warmer temperatures in late spring and early summer may provide the suitable conditions required forM. abietinuscolonies of greater density.
Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection
Authors: Garreau Anne , Blaize Gaëtan , Argenty Jérémy , Rouquié Nelly , Tourdès Audrey , Wood Stephen A. , Saoudi Abdelhadi , Lesourne Renaud 
Published: September 2017

Abstract
Themis is a new component of the TCR signaling machinery that plays a critical role during T cell development. The positive selection of immature CD4+CD8+ double-positive thymocytes and their commitment to the CD4+CD8− single-positive stage are impaired in Themis−/− mice, suggesting that Themis might be important to sustain TCR signals during these key developmental processes. However, the analysis of Themis mRNA levels revealed that Themis gene expression is rapidly extinguished during positive selection. We show in this article that Themis protein expression is increased in double-positive thymocytes undergoing positive selection and is sustained in immature single-positive thymocytes, despite the strong decrease in Themis mRNA levels in these subsets. We found that Themis stability is controlled by the ubiquitin-specific protease USP9X, which removes ubiquitin K48-linked chains on Themis following TCR engagement. Biochemical analyses indicate that USP9X binds directly to the N-terminal CABIT domain of Themis and indirectly to the adaptor protein Grb2, with the latter interaction enabling recruitment of Themis/USP9X complexes to LAT, thereby sustaining Themis expression following positive selection. Together, these data suggest that TCR-mediated signals enhance Themis stability upon T cell development and identify USP9X as a key regulator of Themis protein turnover.
Regulatory T Cell–Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9
Authors: Madireddi Shravan , Eun So-Young , Mehta Amit K. , Birta Aruna , Zajonc Dirk M. , Niki Toshiro , Hirashima Mitsuomi , Podack Eckhard R. , Schreiber Taylor H. , Croft Michael 
Published: September 2017

Abstract
Stimulation of several TNF receptor family proteins has been shown to dampen inflammatory disease in murine models through augmenting the number and/or activity of regulatory T cells (Tregs). We recently found that one molecule, 4-1BB, used binding to Galectin-9 to exert its immunosuppressive effects and drive expansion of CD8+Foxp3− Tregs. We now show that ligation of another TNFR family molecule, DR3, which has previously been found to strongly expand CD4+Foxp3+ Tregs and suppress inflammation, also requires Galectin-9. We found that the extracellular region of DR3 directly binds to Galectin-9, and that Galectin-9 associates with DR3 in Tregs. From studies in vitro with Galectin-9−/− CD4+ T cells and Tregs, we found that stimulatory activity induced by ligating DR3 was in part dependent on Galectin-9. In vivo, in a model of experimental autoimmune encephalomyelitis, we show that an agonist of DR3 suppressed disease, correlating with expansion of CD4+Foxp3+ Tregs, and this protective effect was lost in Galectin-9−/− mice. Similar results were seen in an allergic lung inflammation model. Thus, we demonstrate a novel function of Galectin-9 in facilitating activity of DR3 related to Treg-mediated suppression.
Measurement of straylight for glare assessment and driving.
Authors: Van den Berg Thomas JTP 
Published: September 2017

In this review an overview of straylight as method to assess glare sensitivity for driver licensing will be given. Glare is an important safety issue while driving. It is well known that people stop driving at night because of glare when early cataract develops. It has been found to derive from the physical process of light scattering in the eye, causing a veil of straylight over the road scene. This veil lessens visibility, potentially up till complete blinding. By international agreement, glare is to be quantified by straylight based on the â€œequivalent luminanceâ€ concept. Normal standards have been defined, including age and cataract dependence. Straylight can be measured accurately with the psychophysical 2AFC â€œcompensation comparisonâ€ method, including a reliability check. A commercial instrument called C-Quant is marketed.Â As straylight is a basic quality of the eye, also other aspects of quality of vision, such as face recognition, contrast sensitivity, etc. depend on it. Straylight is used in ophthalmology as early indication for cataract surgery. It is to a large degree independent from acuity. Practical aspects of straylight measurement and limit values for occupational testing will be discussed. Normal young values are around log(s)=0.9. For demanding professions a limit elevation of 2x (0.3 log, corresponding to 3 standard deviations) is proposed. For normal driving a limit elevation of 4x is proposed, corresponding to log(s)=1.5. Cataract surgery is indicated at log(s)=1.4.
Zerstörungsfreie Bewertung der strukturellen Substanz der Asphaltbefestigung mit Geofonen
Authors: Wang Dawei , Liu Pengfei , Otto Frédéric , Oeser Markus , Balck Henning 
Published: September 2017

AbstractDie aktuell in Deutschland genutzten Verfahren zur Beurteilung der Substanz basieren vorwiegend auf der Analyse des Zustands der Oberfläche. Die Zielsetzung des vom Bundesministerium für Verkehr und digitale Infrastruktur beauftragten Forschungsprojekts „In‐Motion“ aus dem nationalen Innovationsprogramm Straße bestand darin, mithilfe verschiedener zerstörungsfreier Verfahren die strukturelle Substanz von Asphaltbefestigungen zu erfassen und zu bewerten. Dieser Ansatz wurde auf der Modellstraße der Bundesanstalt für Straßenwesen (BASt) validiert; auf dem Versuchsfeld der Modellstraße wurden zyklische Belastungen mit dem sog. Mobile Load Simulator (MLS10) zur Simulation von Strukturschädigungen in der Fahrbahn aufgebracht.Durch eine systematische Analyse von Deflektionsmessungen bei bewegter Belastung wurden Rückschlüsse auf das Tragverhalten der Asphaltbefestigungen gezogen. Dabei wurden aus den gemessenen Deflektionen physikalisch begründete Struktur‐ und Materialparameter rechnerisch abgeleitet. Die Rückrechnung erfolgte mithilfe der Methode der finiten Elemente, wobei insbesondere auf eine realitätsnahe Abbildung des jeweiligen Belastungszustands durch bewegte Lasten geachtet wurde. Aus den gewonnenen Erkenntnissen wurde ein eigenständiges Modul erarbeitet, welches als Grundlage für eine konzeptionelle Erweiterung bestehender Pavement‐Managementsysteme hin zu einer realistischeren Berücksichtigung der Substanzwerte von flexiblen Befestigungen dienen kann.
Synthesis and Biological Evaluation of O‐Methylated Glycolipids Related to PGLs via Direct Stereoselective Glycosidation and Sequential Suzuki–Miyaura Coupling using Boracyclane
Authors: Sato Ko , Omahdi Zakaria , Shibata Kensuke , Sonoda Koh‐hei , Yamasaki Sho , Tanaka Hiroshi 
Published: September 2017

AbstractSynthesis of O‐methylated glycolipids via direct stereoselective glycosidation whose sugar moieties are related to those in phenolic glycolipids (PGLs) is reported. Treatment of 2‐O‐methyl‐rhamnosyl imidates with I2 and nBu4NOTf resulted in their activation under low temperature and provided the α‐rhamnosides with excellent α‐selectivity. nBu4NOTf enhanced the electorophilicity of iodine. This methodology improved the efficiency of the synthesis of both PGL‐1 and PGL‐tb1 sugars. The process involved the formation of 2‐O‐naphthylmethyl‐α‐rhamnoside and 2‐O‐methyl‐α‐fucoside. Sequential Suzuki–Miyaura coupling using synthetic glycosides, boracyclane, and aryl bromides provided glycolipids related to PGL sugars, and was accomplished with a one‐pot process. Finally, we elucidated the immunosuppressive activities of all these synthetic compounds and found that a phenyl 3‐O‐α‐rhamnosyl‐2‐O‐methyl‐α‐rhamnoside possessing a 6‐(2‐naphthyl)hexyl group exhibited the strongest inhibitory effect.
Live long and prosper: plant–soil feedback, lifespan, and landscape abundance covary
Authors: Kulmatiski Andrew , Beard Karen H. , Norton Jeanette M. , Heavilin Justin E. , Forero Leslie E. , Grenzer Josephine 
Published: September 2017

AbstractPlant soil feedbacks (PSFs) are thought to be important to plant growth and species coexistence, but most support for these hypotheses is derived from short‐term greenhouse experiments. Here we use a seven‐year, common garden experiment to measurePSFs for seven native and six nonnative species common to the westernUnited States. We use these long‐term, field‐based estimates to test correlations betweenPSFand plant landscape abundance, species origin, functional type, and lifespan. To assess potentialPSFmechanisms, we also measured soil microbial community composition, root biomass, nitrogen cycling, bulk density, penetration resistance, and shear strength. Plant abundance on the landscape and plant lifespan were positively correlated withPSFs, though this effect was due to the relationships for native plants.PSFs were correlated with indices of soil microbial community composition. Soil nutrient and physical traits and root biomass differed among species but were not correlated withPSF. While results must be taken with caution because only 13 species were examined, these species represent most of the dominant plant species in the system. Results suggest that native plant abundance is associated with the ability of long‐lived plants to create positive plant–soil microbe interactions, while short‐lived nonnative plants maintain dominance by avoiding soil‐borne antagonists, increasing nitrogen cycling and dedicating resources to aboveground growth and reproduction rather than to belowground growth. Broadly, results suggest thatPSFs are correlated with a suite of traits that determine plant abundance.