bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined strategy of device‐based contrast minimization and urine flow rate‐guided hydration to prevent acute kidney injury in high‐risk patients undergoing coronary interventional procedures
Authors: Paolucci Luca , De Micco Francesca , Scarpelli Mario , Focaccio Amelia , Cavaliere Valeria , Briguori Carlo 
Published: September 2024

AbstractBackground and AimsContrast‐associated acute kidney injury (CA‐AKI) is a major complication following coronary procedures. We aimed to evaluate the effectiveness of a combination of urine flow rate‐(UFR) guided hydration (RenalGuardTM) and device‐based contrast media (CM) reduction (DyeVertTM) in CA‐AKI prevention.MethodsStable high‐risk patients undergoing coronary procedures with the use of DyeVertTM and RenalGuardTM were prospectively included (Combined group) and matched with a similar cohort of patients treated only with RenalGuardTM in whom CM volume was controlled by operator‐dependent strategies (Control group). CA‐AKI was defined as a serum creatinine increase ≥0.3 mg/dL at 48 h.ResultsOverall, 55 patients were enrolled and matched with comparable controls. Patients in the Combined group were exposed to a lower CM dose (Control: 55 [30–90] mL vs. Combined: 42.1 [24.9–59.4] mL; p = 0.024). A significant interaction was found between treatment allocation and serum creatinine changes (p = 0.048). CA‐AKI occurred in five (9.1%) patients in the Combined group and in 14 (25.4%) patients in the Control group (OR 0.29, 95% CI [0.09–0.88]).ConclusionsA combined strategy of device‐based CM reduction plus UFR‐guided hydration is superior to operator‐dependent CM sparing strategies plus UFR‐guided hydration in preventing CA‐AKI in high‐risk patient.
Transpassive Behavior of Equimolar CrMnFeCoNi and CrCoNi Multi‐Principal Element Alloys in an Alkaline NaCl Electrolyte
Authors: Wetzel Annica , Morell Daniel , von der Au Marcus , Witt Julia , Ozcan Ozlem 
Published: September 2024

AbstractWe investigated the corrosion properties and transpassive behavior of CrMnFeCoNi and CrCoNi multi‐principal element alloys (MPEAs) in a 0.1 M NaCl electrolyte at pH 12. By using SECM‐based tip substrate voltammetry (TSV) in combination with the chemical analysis of the electrolyte, we were able to differentiate between anodic metal dissolution and oxygen evolution in the transpassive range. Our investigations have shown that CrCoNi has a significantly higher corrosion resistance compared to CrMnFeCoNi. In the studied alkaline environment, a transpassive oxide film is formed on the surface of CrCoNi during secondary passivation. This transpassive oxide film appears to play a significant role in oxygen evolution, as the increase in TSV currents at the microelectrode coincides with the corresponding current density plateau of the voltametric current trace. The formation of the transpassive oxide film was not observed in previous studies conducted in acidic environments. Moreover, the alkaline electrolyte induced a positive hysteresis and mild pitting corrosion, in addition to intergranular corrosion, which was the sole corrosion process observed at acidic pH levels. These findings enhance the understanding of the processes governing the transpassivity of CrMnFeCoNi and CrCoNi MPEAs in alkaline environments and have potential implications for the development of application‐tailored corrosion‐resistant MPEAs.
Uncovering the Potent Antiviral Activity of the Sesterterpenoids from the Sponge Ircinia Felix Against Human Adenoviruses: from the Natural Source to the Total Synthesis
Authors: Ruiz‐Molina Ana , Pech‐Puch Dawrin , Millán Ramón E. , Ageitos Lucía , Villegas‐Hernández Harold , Pachón Jerónimo , Pérez Sestelo José , Sánchez‐Céspedes Javier , Rodríguez Jaime , Jiménez Carlos 
Published: September 2024

AbstractHuman Adenovirus (HAdV) infections in immunocompromised patients can result in disseminated diseases with high morbidity and mortality rates due to the absence of available treatments for these infections. The sponge Ircinia felix was selected for the significant anti‐HAdV activity displayed by its organic extracts. Its chemical analysis yielded three novel sesterterpene lactams, ircinialactams J−L, along with three known sesterterpene furans which structures were established by a deep spectrometric analysis. Ircinialactam J displayed significant antiviral activity against HAdV without significant cytotoxicity, showing an effectiveness 11 times greater than that of the standard treatment, cidofovir®. Comparison of the antiviral evaluation results of the isolated compounds allowed us to deduce some structure‐activity relationships. Mechanistic assays suggest that ircinialactam J targets an early step of the HAdV replicative cycle before HAdV genome reaches the nucleus of the host cell. The first total synthesis of ircinialactam J was also accomplished to prove the structure and to provide access to analogues. Key steps are a regio‐ and stereoselective construction of the trisubstituted Z‐olefin at Δ7 by iron‐catalyzed carbometallation of a homopropargylic alcohol, a stereoselective methylation to generate the stereogenic center at C18, and the formation of the (Z)‐Δ20 by stereoselective aldol condensation to introduce the tetronic acid unit. Ircinialactam J is a promising chemical lead to new potent antiviral drugs against HAdV infections.
Solvent‐Selective Fluorescence Sensing of Mg2+ and Al3+ Ions by Pincer‐Type NNO Schiff Base Ligand: An Experimental and DFT Optimized Approach
Authors: Dev Keshav , Singh Shiva , Bhardwaj Shakshi , Kukreti Prashant , Ramakanth Dakuri , Kumar Pankaj , Saini Saakshi , Roy Partha , Srivastava Vimal Chandra , Ghosh Kaushik , Maji Pradip K. 
Published: September 2024

AbstractA newly developed dual‐functional fluorescence sensing probe (phenylhydrazinyl pyridine) Schiff base (SB) has been designed with good selectivity for distinguishing Mg2+ and Al3+ metal ions in different solvent solutions. SB exhibits quick and visual turn‐on fluorescence enhancement in response to Mg2+ and Al3+ detection. The addition of Mg2+ in ACN–HEPES buffer (1 : 1, v/v, pH 7.2) at (λmax=390 nm) and Al3+ in MeOH–HEPES buffer (1 : 1, v/v, pH 7.2) at (λmax=360 nm) resulted in significant enhancement of fluorescence, up to 7–9 times. These low detection limits of 7.1×10−6 M (7.1 μM) and 5.15×10−7 M (0.51 μM) for Mg2+ and Al3+, respectively, have been achieved by this solvent‐controlled platform. Due to the sensing potential towards Mg2+, the probe was utilized as an imaging material for breast cancer cells. 1H‐NMR studies were utilized to explore SB's sensing mechanism through turn‐on fluorescence. Density functional theory (DFT) calculations were utilized to validate optimized SB and its intricate geometries, which govern the sensing mechanism in the solvent environment. Such a probe has extensive potential applications in bioimaging and the assessment of the quality of wastewater.
The American Cancer Society National Lung Cancer Roundtable strategic plan: Provider engagement and outreach
Authors: Lewis Jennifer A. , Klein Deborah E. , Eberth Jan M. , Carter‐Bawa Lisa , Studts Jamie L. , Tong Betty C. , Smith Robert A. , Kazerooni Ella A. , Houston Thomas P. 
Published: September 2024

AbstractThe American Cancer Society National Lung Cancer Roundtable strategic plan for provider engagement and outreach addresses barriers to the uptake of lung cancer screening, including lack of provider awareness and guideline knowledge about screening, concerns about potential harms from false‐positive examinations, lack of time to implement workflows within busy primary care practices, insufficient infrastructure and administrative support to manage a screening program and patient follow‐up, and implicit bias based on sex, race/ethnicity, social class, and smoking status. Strategies to facilitate screening include educational programming, clinical reminder systems within the electronic medical record, decision support aids, and tools to track nodules that can be implemented across a diversity of practices and health care organizational structures.Plain language summaryThe American Cancer Society National Lung Cancer Roundtable strategic plan to reduce deaths from lung cancer includes strategies designed to support health care professionals, to better understand lung cancer screening, and to support adults who are eligible for lung cancer screening by providing counseling, referral, and follow‐up.
The American Cancer Society National Lung Cancer Roundtable strategic plan: Introduction
Authors: Kazerooni Ella A. , Wood Douglas E. , Rosenthal Lauren S. , Smith Robert A. 
Published: September 2024

AbstractLung cancer is the leading cause of cancer death in the United States and across the world. The American Cancer Society National Lung Cancer Roundtable (ACS NLCRT) was established in 2017 as a consortium of public, private, and voluntary organizations with a mission to lower the impact of lung cancer via prevention, early detection, and optimal therapy. The ACS NLCRT supports a comprehensive scope of work that covers the lung cancer continuum, from risk reduction, tobacco prevention and control, and early detection (screening and incidental lung nodule management) to guideline‐based staging, biomarker testing, treatment, and survivorship and overarching issues such as stigma and nihilism, health equity, and tactical approaches such as state coalition efforts and policy initiatives. Applying a multidimensional and multisector approach, over 220 public, private, and government agency member organizations and 250 volunteer experts, patients, and caregiver advocate representatives collaborate to address challenges across the lung cancer continuum by catalyzing action to conceive, build, and strengthen innovative solutions. The wide‐ranging membership allows the ACS NLCRT to harness the collective power and expertise of the entire lung cancer community by connecting leaders, communities, and systems to improve equity and access. These national, state, and local relationships provide partnerships for the dissemination of ACS NLCRT–developed tools and resources. This article describes the ACS NLCRT and introduces the series of accompanying and future articles that together make up the ACS NLCRT strategic plan, which provides a roadmap for future research, investment, and collaboration to reduce lung cancer mortality and lung cancer–related stigma and enhance survivorship.
New Ustekinumab Biosimilar Candidate FYB202: Pharmacokinetic Equivalence Demonstrated in a Randomized, Double‐Blind, Parallel‐Group, Single‐Dose Trial in Healthy Subjects
Authors: Balser Sigrid , Nopora Katrin , Körner Juliane , Wedemeyer Ralph‐Steven , Anschütz Maria , Schug Barbara 
Published: September 2024

AbstractIn the RUSTIC trial, pharmacokinetic (PK) similarity between the proposed ustekinumab biosimilar FYB202 and EU‐approved (EU‐Ref) and US‐licensed ustekinumab (US‐Ref) as well as between both reference drugs was assessed after a single 45‐mg subcutaneous injection. Safety analyses comprised immunogenicity (antidrug antibodies, neutralizing antibodies), adverse events, and local tolerability. Overall, 491 healthy adults were randomized 1:1:1 and observed for up to 112 days; 486 completed the trial, and 478 were included in the PK analysis. All 3 comparisons showed PK similarity, since the 90% confidence intervals of the respective geometric mean ratios for area under the concentration‐time curve from time 0 to infinity and maximum serum concentration were contained within the acceptance interval of 80%‐125%. No clinically meaningful differences regarding overall safety, immunogenicity, and local tolerability were observed. Notably, after FYB202 administration, in fewer subjects at least 1 positive antidrug antibody result was observed compared to the reference groups (FYB202, 20%; EU‐Ref, 42%; US‐Ref, 51%). In conclusion, the RUSTIC trial demonstrated equivalent PK characteristics for FYB202 when compared to both EU‐Ref and US‐Ref ustekinumab and between both reference drugs. It provides the basis for the marketing authorization of FYB202, together with an extensive analytical characterization and the results of a confirmatory efficacy and safety trial in patients with moderate to severe plaque psoriasis.
A systematic multi attributes fuzzy‐based decision‐making to migrate the monolithic paradigm electronic governance applications to new software architecture
Authors: Tyagi Nitin Kumar , Tyagi Kanchan 
Published: September 2024

SummaryIn the context of electronic governance, traditional monolithic architectures often struggle with the efficient exchange of information and analytics due to their centralized nature. Emerging architectural paradigms such as Service‐Oriented Architecture, Microservices Architecture (MSA), Distributed/Decentralized Technology, and Blockchain Technology offer potential solutions to these challenges. This white paper conducts a literature review to identify the factors influencing the decision to migrate from monolithic systems to these new architectures. By applying a multi‐attribute fuzzy‐based technique for order preference by similarity to ideal solution (TOPSIS), the study evaluates and ranks these architectures based on their ability to meet the requirements of modern electronic governance applications. The results are compared with other ranking multi‐criteria decision‐making techniques like fuzzy analytical hierarchical process and intuitionistic fuzzy TOPSIS (IFTOPSIS). The findings indicate that MSA ranks highest among the available options. Each architecture offers distinct advantages that can address the limitations of traditional systems but also come with challenges. This paper also considers these factors along with a well‐defined strategy and risk management plan essential for a successful migration.
Oral anticoagulation in patients with hypertrophic cardiomyopathy and non‐valvular atrial fibrillation in Japan
Authors: Kitaoka Hiroaki , Carroll Robert , Eugene Natalie , Teixeira Bruno Casaes , Matsuo Yukako , Kubo Toru 
Published: September 2024

AbstractAimsThere are limited data to support direct oral anticoagulant (DOAC) use in patients with hypertrophic cardiomyopathy (HCM) and non‐valvular atrial fibrillation (NVAF). The current study investigated the safety and effectiveness of DOACs versus warfarin in patients in Japan.MethodsThis retrospective observational study assessed a Japanese cohort of patients diagnosed with HCM and NVAF between July 2011 and June 2021 using a Japanese claims database. Propensity score (PS) matching (2:1 DOAC:warfarin) using the nearest‐neighbour method was applied to balance demographic and clinical characteristics between treatment groups. The primary outcomes were the risk of major bleeding and any bleeding (major or minor). Secondary outcomes included describing baseline demographic and clinical characteristics and the risk of stroke/systemic embolism (SE).ResultsAfter PS matching, 2955 DOAC‐ and 1603 warfarin‐treated patients were assessed. The mean [standard deviation (SD)] age in the DOAC and warfarin groups was 74.8 (10.5) and 75.3 (10.2) years, respectively. The majority of patients were male (DOAC, 58.8%; warfarin, 59.6%), had comorbidities (DOAC, 97.5%; warfarin, 96.6%), and were treated with β‐blockers (DOAC, 62.5%; warfarin, 62.3%). The risk of major and any bleeding was similar across cohorts [hazard ratio (HR), 0.80; 95% confidence interval (CI), 0.50–1.27; P = 0.336 and HR, 0.93; 95% CI, 0.78–1.11; P = 0.420] while the risk of stroke/SE was lower among patients treated with DOACs (HR, 0.67; 95% CI, 0.47–0.96; P = 0.027). Factors associated with an increased risk of major bleeding included prior bleeding (HR, 1.97; 95% CI, 1.22–3.17) and chronic kidney disease (HR, 1.87; 95% CI, 1.10–3.18). An increased risk of stroke/SE was associated with prior ischaemic stroke (HR, 2.97; 95% CI, 2.05–4.29), peripheral arterial disease (HR, 1.88; 95% CI, 1.22–2.88) and chronic kidney disease (HR, 1.87; 95% CI, 1.24–2.83).ConclusionsDOAC‐treated patients had a lower risk of stroke/SE and a comparable risk of bleeding compared with warfarin‐treated patients. Prior stroke was shown to augment stroke risk by approximately three‐fold. This large real‐world study suggests that patients diagnosed with HCM and NVAF can be safely and effectively treated with DOACs in Japan.
Insights Into the Magnesium‐Catalyzed C−C Coupling of Terminal Alkynes with Carbodiimides
Authors: Mukhopadhyay Sayantan , Rajput Sagrika , Sahoo Rajata Kumar , Nembenna Sharanappa 
Published: September 2024

AbstractThe bis‐guanidinate anion stabilized amido magnesium (II) compound [LMgN(SiMe3)2; L={(ArHN)(ArN)−C=N−C=(NAr)(NHAr); Ar=2,6‐Et2−C6H3}] (Mg‐1) has been synthesized and characterized. It has been successfully employed as a pre‐catalyst for the catalytic C−C coupling of terminal alkynes with carbodiimides, producing propiolamidine products with moderate to good yields. The active catalyst bis‐guanidinate magnesium acetylide [LMgC≡C−Ph]2 (Mg‐2) and the intermediate magnesium propiolamidinate [LMg{(NiPr)2C}C≡C−Ph] (Mg‐3) involved in the catalytic reaction were isolated and thoroughly characterized through multinuclear NMR and mass spectral analyses, as well as single crystal X‐ray diffraction studies. Based on the above findings, a plausible mechanistic cycle has been proposed. Additionally, a new example of bis‐guanidinate supported structurally characterized magnesium propiolamidate compound [LMg{(4−CH3−C6H4)N−(C−C≡C−Ph)=O]2 (Mg‐4) has been described via the reaction between Mg‐2 and isocyanate.
Synthesis of 2‐(Pentafluoro‐λ6‐sulfanyl)acetamides and Impact of the Fluorinated Group on the Lipophilicity
Authors: Mastalerz Vincent , Verret Laurianne , Paquin Jean‐François 
Published: September 2024

AbstractThe synthesis of 2‐(pentafluoro‐λ6‐sulfanyl)acetamides is described via an amidation reaction between 2‐(pentafluoro‐λ6‐sulfanyl)acetic acid, the SF5‐containing building block, and various amines. A total of 27 examples of SF5‐containing amides were synthesized, with isolated yields going from 43 % to quantitative. We showed that a 2‐(pentafluoro‐λ6‐sulfanyl)acetamide could be converted to a N‐(2‐SF5‐ethyl)amine and a SF5‐containing oxadiazoles. Finally, the effect of the SF5 substituent on the lipophilicity of the amide of a model compound was evaluated.
An Experimentally Designed Sertaconazole Sensor for Selective and Enhanced Potentiometric Response: Determination in Cream, Plasma and in Presence of Other Imidazoles
Authors: Tantawy Mahmoud A. , Soliman Shymaa S. , Abdel Rahman Mona A. 
Published: September 2024

AbstractA two‐step experimental design was followed to develop a potentiometric solid contact ion‐selective electrode for sertaconazole (STN) determination. A full factorial design was first employed in screening for the best cation exchanger, ionophore and conducting polymer. Amounts of the selected cation exchanger; tetrakis[3,5‐bis(trifluoromethyl)phenyl] borate (TFPB), and ionophore; calix[6]arene (CX6), incorporated in STN sensing membrane were then optimized with the aid of face centered composite design. Calibration slope, detection limit and electrode selectivity in presence of another imidazole‐classified drug; econazole, were the selected responses in both designs. The optimized ion‐sensing membrane, containing 1.0 mg TFPB and 9.9 mg CX6, showed enhanced responses compared to the primarily screened ones. This optimized electrode exhibited a linear response over a concentration range of 1.0×10−6‐−1.0×10−3 M with a Nernstian slope of 57.50 mV/decade. The detection limit was lowered by about one order of magnitude via this optimization to equal 3.16×10−7 M. The proposed electrode was successfully challenged for STN determination in the presence of other imidazoles. It was then used for STN determination in cream and spiked plasma as an example of biological fluid. Our proposed potentiometric method was finally compared to the reported chromatographic ones in terms of sensitivity, and greenness evaluation by the widely applicable Analytical GREEnness (AGREE) tool. The comparison revealed the superiority of our method in terms of sensitivity and sustainability.
Developing a resilient framework for electric vehicle charging stations harnessing solar energy, standby batteries and grid integration with advanced control mechanisms
Authors: Mazumdar Debabrata , Biswas Pabitra K. , Sain Chiranjit , Ahmad Furkan , Al‐Fagih Luluwah 
Published: September 2024

AbstractA direct consequence of the rapid expansion of civilization and modernization trends is the escalation in global warming and the consequential climatic upheavals. The world has actively advocated the adoption of electric vehicles (EVs) as a response to the environmental challenges posed by vehicular emissions. It is evident that conventional fuel‐based charging infrastructures are economically impractical and lack organizational cohesion in light of the proliferation of EVs. An EV charging station powered by renewable energy presents a promising opportunity for enhancing flexibility and control. It is imperative that EV charging stations be equipped with solar power and standby batteries (SBBs). Consequently, this article presents and evaluates a system that utilizes a proportional‐integral‐derivative controller, a neural network‐equipped grid and a charging station utilizing a Dragon Fly Optimization Algorithm to generate power and a maximum power point tracking controller. To achieve optimal power management within the charging station, MATLAB/Simulink is used to implement and rigorously test the proposed system. It orchestrates the interaction between the solar panel, backup battery, grid and EVs. Compared to existing systems in the literature, the comprehensive system exhibits commendable efficiency. Due to the pivotal role played by grid integration and the SBB, the system can ensure a reliable power supply to the charging station under any weather conditions.
Exhausted plant cell culture media as potential biostimulants to enhance plant growth and nitrogen use efficiency in tomatoes under optimal and reduced nitrogen supply
Authors: Cannata Claudio , Basile Federico , La Bella Emanuele , Arciello Stefania , Abreu Ana Cristina , Fernández Ignacio , Leonardi Cherubino , Mauro Rosario Paolo 
Published: September 2024

AbstractBackgroundInefficient nitrogen (N) use leads to economic losses and environmental harm. Improving N use efficiency (NUE) is crucial. The use of plant biostimulants (PBs), integrated with good agronomic practices, offers a sustainable solution.AimsThe study explores the potential use of exhausted cell culture media from plant cell cultures (Nicotiana sp. and Gardenia sp.) as PBs, assessing their role in enhancing plant physiological status and NUE. It also compares their effectiveness against commercial PBs.MethodsTwo experiments (Experiments 1 and 2) were conducted using cherry tomato plants. In the first one, the two media were applied at different concentrations as a foliar spray to define the optimal dose. This outcome was used to set up Experiment 2, in which both media were compared to commercial PBs under optimal and reduced N supply. Measurements included plant growth, chlorophyll (Chl) content, and NUE indices. Moreover, Experiment 2 examined gene expression related to N assimilation, transport, and response to oxidative stress.ResultsBoth experiments demonstrated a significant increase in leaf area (≈11%) and aboveground biomass (≈13%) using exhausted media. Furthermore, Experiment 2 demonstrated enhancements in Chl content (≈10%) and plant N accumulation (≈20%). These findings indicate that exhausted media has a comparable efficacy to commercial PBs.ConclusionsThe study underscores the practical viability of exhausted cell culture media as effective PBs for tomato growth in both N conditions. This approach aligns with sustainability objectives by repurposing by‐products to enhance plant resilience against abiotic stress and potentially improve the efficiency of N fertilizers.