bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing connectivity and coverage in wireless sensor networks: a hybrid comprehensive learning-Fick’s algorithm with particle swarm optimization for router node placement
Authors: Amer Dina A. , Soliman Sarah A. , Hassan Asmaa F. , Zamel Amr A. 
Published: September 2024

AbstractWireless Sensor Networks (WSNs) are essential for collecting and transmitting data in modern applications that rely on data, where effective network connectivity and coverage are crucial. The optimal placement of router nodes within WSNs is a fundamental challenge that significantly impacts network performance and reliability. Researchers have explored various approaches using metaheuristic algorithms to address these challenges and optimize WSN performance. This paper introduces a new hybrid algorithm, CFL-PSO, based on combining an enhanced Fick’s Law algorithm with comprehensive learning and Particle Swarm Optimization (PSO). CFL-PSO exploits the strengths of these techniques to strike a balance between network connectivity and coverage, ultimately enhancing the overall performance of WSNs. We evaluate the performance of CFL-PSO by benchmarking it against nine established algorithms, including the conventional Fick’s law algorithm (FLA), Sine Cosine Algorithm (SCA), Multi-Verse Optimizer (MVO), Salp Swarm Optimization (SSO), War Strategy Optimization (WSO), Harris Hawk Optimization (HHO), African Vultures Optimization Algorithm (AVOA), Capuchin Search Algorithm (CapSA), Tunicate Swarm Algorithm (TSA), and PSO. The algorithm’s performance is extensively evaluated using 23 benchmark functions to assess its effectiveness in handling various optimization scenarios. Additionally, its performance on WSN router node placement is compared against the other methods, demonstrating its competitiveness in achieving optimal solutions. These analyses reveal that CFL-PSO outperforms the other algorithms in terms of network connectivity, client coverage, and convergence speed. To further validate CFL-PSO’s effectiveness, experimental studies were conducted using different numbers of clients, routers, deployment areas, and transmission ranges. The findings affirm the effectiveness of CFL-PSO as it consistently delivers favorable optimization results when compared to existing methods, highlighting its potential for enhancing WMN performance. Specifically, CFL-PSO achieves up to a 66.5% improvement in network connectivity, a 16.56% improvement in coverage, and a 21.4% improvement in the objective function value when compared to the standard FLA.
Digital exclusion as a barrier to accessing healthcare: a summary composite indicator and online tool to explore and quantify local differences in levels of exclusion
Authors: Mee Paul , Gussy Mark , Huntley Phil , Kenny Amanda , Jarratt Theo , Kenward Nigel , Ward Derek , Vaughan Aiden 
Published: September 2024

AbstractExisting disparities in digital access were exacerbated with the accelerated shift to online provision of services during the COVID-19 pandemic, particularly for already disadvantaged groups. Metrics to quantify relative local differences in levels of digital exclusion are a necessary pre-requisite for the targeting of interventions to address these disparities. In this study we developed a composite indicator and an interactive dashboard ‘The Lincolnshire Digital Health Toolkit’ to explore digital exclusion in Lincolnshire, UK. To develop the indicator, individual variables were normalised and aggregated, intra-variable correlations explored, and factor analysis used to determine variable weightings. Three underlying factors were identified that explained a significant proportion of the variance in the original variables, the first two predominantly related to socioeconomic deprivation and lack of activity. In general, coastal areas in the east of the county had higher levels of digital exclusion, with significant local variation particularly within urban areas. Long travel times to reach medical facilities are an additional barrier in some communities. The toolkit has been used to support the evidence-based geographic targeting of interventions to address barriers to accessing digitally based health information and services. The impact of digital exclusion must be addressed to reduce marginalisation and isolation. The Lincolnshire Digital Health Toolkit provides a novel composite metric tailored to the conditions of this largely rural county and an interactive dashboard to support decisions on resource allocation.
Biocompatibility and antimicrobial effect of demineralised dentin matrix hydrogel for dental pulp preservation
Authors: Sultan Nessma , Camilleri Josette , Scheven Ben A. 
Published: September 2024

AbstractRegeneration of dentin and preserving pulp vitality are essential targets for vital pulp therapy. Our study aimed to evaluate a novel biomimetic pulp capping agent with increased dentin regenerative activities. To produce demineralised dentin matrix (DDM) particles, human extracted teeth were ground and treated with ethylene diamine tetra-acetic acid solution. DDM particles were added to sodium alginate and this combination was dripped into a 5% calcium chloride to obtain DDM hydrogel (DDMH). The eluants of both DDMH and mineral trioxide aggregate (MTA) were tested using an MTT assay to detect their cytotoxic effect on dental pulp stem cells (DPSC). Collagen-I (COL-I) gene expression was analysed on DPSC exposed to different dilutions of pulp capping material eluants by real-time quantitative polymerase chain reaction. Acridine orange staining was used to monitor the cell growth over the tested materials. Agar diffusion assay was utilised to test the antibacterial effect of DDMH and MTA compared to controls. MTT assay revealed that neat eluates of DDMH promoted DPSC viability. However, neat eluates of MTA were cytotoxic on DPSC after 72 h of culture. Moreover, DPSC were capable of growth and attached to the surface of DDMH, while they showed a marked reduction in their number when cultured on the MTA surface for one week, as shown by the acridine orange stain. In DPSC cultured with DDMH eluates, the COL-I gene was overexpressed compared to those cultured with MTA eluants. DDMH had significant antimicrobial activity in comparison to MTA after 24 h incubation. This in vitro study showed that DDMH could be an alternative pulp capping agent for regenerative endodontics.
Ocular genetics in the Japanese population
Authors: Hotta Yoshihiro , Torii Kaoruko , Takayama Masakazu 
Published: September 2024

AbstractIn today’s globalized society, ophthalmologists can examine people of different ethnicities regardless of where they live. The frequency of disease-causing genes varies according to a patient’s ethnic background. We explain genetic findings for Japanese patients with inherited eye diseases. Ocular genetics has made great advances over the past 30 years. For example, detecting mutations at nucleotide position 11778 in mitochondrial DNA was useful in the genetic diagnosis of Leber’s hereditary optic neuropathy (LHON). I evaluated the genotype-phenotype relationship in cases of corneal dystrophy and inherited retinal dystrophy (IRD). I identified the entire exon sequence of the eyes shut homolog (EYS) gene in patients with autosomal recessive retinitis pigmentosa (RP). EYS gene mutations are the most frequent cause of autosomal recessive RP. RPGRIP1 may be a common causative gene with early-onset severe retinal dystrophy, including Leber congenital amaurosis. However, some genes have complex structures that are difficult to analyze, including the OPN1LW/OPN1MW gene cluster in blue cone monochromacy and the IKBKG/NEMO genes in incontinentia pigmenti. This review will also present two cases with uniparental disomy, a case of IRD with double mutations, and a case with RP complicated with LHON-like neuropathy. Precise understanding of the effects of genetic variants may reveal differences in the clinical characteristics of patients with the same variant. When starting genome medicine, accurately diagnosing the patient, making accurate prediction, determining the genetic pattern, and providing genetic counseling are important. Above all, that both the doctors and patients understand genetic diseases correctly is important.
Characterization of an Advanced Blast Simulator for Investigation of Large Scale Blast Traumatic Brain Injury Studies
Authors: Nelson Allison J. , Ritzel David , Showalter Noah , Boppe Danny , Riegel Andy , VandeVord Pamela J. 
Published: September 2024

Abstract
Blast traumatic brain injury (bTBI) is a prominent military health concern. The pervasiveness and long-term impacts of this injury highlight the need for investigation of the physiological outcomes of bTBI. Preclinical models allow for the evaluation of behavioral and neuropathological sequelae associated with bTBI. Studies have implemented rodent models to investigate bTBI due to the relative small size and low cost; however, a large animal model with similar neuroanatomical structure to humans is essential for clinical translation. Small blast simulators are used to induce bTBI in rodents, but a large animal model demands a larger device. This study describes a large advanced blast simulator (ABS4) that is a gas-detonation-driven system consisting of 5 sections totaling 40 ft in length with a cross-section of 4 × 4 ft at the test section. It is highly suitable for large animals and human surrogate investigations. This work characterized the ABS4 in preparation of large-scale bTBI testing. An array of tests were conducted with target overpressures in the test section ranging from 10 to 50 psi, and the pressure-time profiles clearly illustrate the essential characteristics of a free-field blast wave, specifically a sharp peak pressure and a defined negative phase. Multiple blast tests conducted at the same target pressure produced very similar pressure profiles, exhibiting the reproducibility of the ABS4 system. With its extensive range of pressures and substantial size, the ABS4 will permit military-relevant translational blast testing.
Proposal for a framework for environmental zoning of areas near gold mines based on the distribution of potentially toxic elements, pollution indices, and bioindicators: a case study in Antioquia, Colombia
Authors: López Julián E. , Marín Juan F. , Saldarriaga Juan F. 
Published: September 2024

AbstractGold mining, even under strict environmental regulations, inevitably causes environmental impacts and liabilities. To address this, the study proposes a framework for environmental zoning around gold mines based on the distribution of potentially toxic elements (PTEs), pollution indices, and bioindicators. Soil samples were collected from municipalities affected by gold mining projects, and concentrations of As, Cd, Pb, and Cr were measured. Then, the Pollution Load Index (PLI) was calculated. A plant model was used for the biomonitoring of PTEs, and the Plant Vigor Index (PVI) was determined. Finally, environmental zoning was proposed through geospatial analysis combining PTEs, PLI, and PVI values. The concentrations of PTEs were as follows: As ranged from 1.7 to 892, Cd from 0.1 to 65.2, Pb from 18.5 to 2345, and Cr from 5.4 to 118.4. Spearman’s rank correlation showed significant relations (ρ > 0.76) between bioindicators and PTE concentrations and PLI. The PVI correlated significantly with PTE concentrations (ρ − 0.41 to − 0.67) and PLI (ρ − 0.65). The municipalities were categorized into three zones: highly contaminated, moderately contaminated, and minimally contaminated. Overall, the environmental zoning maps serve as a management tool for environmental monitoring.
Disconnected Connections of Learning Beyond Formal Schooling Through Human–Computer–Human Interactions
Authors: Prestridge Sarah , Tan Seng Chee , Jacobsen Michele , Hoppe H. Ulrich , Angeli Charoula , Milrad Marcelo , Pangeni Shesha Kanta , Kovatcheva Eugenia , Kafyulilo Ayoub , Flanagan Brendan , Khaddage Ferial 
Published: September 2024

AbstractThis article originated from a working group on “Learning beyond formal schooling through human–computer–human interaction (HCHI)” convened at the UNESCO EDUSummIT 2023 in Kyoto (Japan). A polylogue approach was adopted by engaging eight co-authors whose diverse perspectives culminated in propositions that addressed the pivotal question: How should the connections between formal, non-formal, and informal learning be considered in a digitally mediated world? Formal learning is typically structured, organized and chronologically arranged institutional learning, whereas informal learning is associated with everyday learning across contexts throughout one’s life, and non-formal learning is a hybrid of these forms of learning. Considering the growing prominence of informal and non-formal learning in a digitally mediated world, the evolving learning ecosystem calls for a recalibration of the emphasis on formal learning. In this regard, HCHI has the potential to mediate human–human interactions, thereby bridging formal and informal learning. Our articulated position is to preserve the distinct boundaries and inherent complexities of each type of learning while creating opportunities or ‘bridges’ to authentically draw on the processes of each through meaningful actions. The polylogue yielded three propositions to bridge the connections between formal, non-formal and informal learning spaces in a digitally mediated world: (a) formal education institutions can establish strategic alliances and collaborations with learning organizations beyond the formal educational system, (b) the creation of digital learning communities within formal and non-formal spaces exemplify a paradigm of operation in an unregulated, student-centric cohesive space where the educator is a co-participant, (c) the recognition of the value of informal learning experiences by formal education institutions is critical, with emphasis on the learning process rather than the product.
Intraspecific Variation in the Alkaloids of Adalia decempunctata (Coleoptera, Coccinellidae): Sex, Reproduction and Colour Pattern Polymorphism
Authors: Aslam Muhammad , Nedvěd Oldřich , Sloggett John J. 
Published: September 2024

AbstractIn this paper, we examine intraspecific variation in the quantity of alkaloid chemical defence in field collected individuals of the polymorphic ladybird beetle Adalia decempunctata (10-spot ladybird). Like its more widely studied relative Adalia bipunctata (2-spot ladybird), A. decempunctata possesses the alkaloids adaline and adalinine, which are, respectively, the major and minor alkaloids of A. bipunctata. We focused especially on alkaloid concentration in relation to colour pattern morph, sex, and the relationship between female and egg parameters. There was a marked sexual dimorphism in the balance of the two alkaloids, with adaline predominating in females and adalinine predominating in males: in males, on average, over 70% of total alkaloid was adalinine. Females had a lower proportion of adalinine (< 10%) than their eggs (> 15%) and relationships between egg alkaloid and female alkaloid or fecundity were weak or non-existent. Colour pattern morph had a borderline (although not) significant relationship with adaline concentration and total alkaloid concentration, which could be further explored with laboratory reared individuals. The sexual dimorphism in alkaloid content, which seems likely due to differences in synthesis, might be related to their relative costs to the two sexes and might provide insight into the evolution of alkaloid diversity in ladybirds.
Assessing the Preservation Effectiveness: A Comparative Study of Plasma Activated Water with Various Preservatives on Capsicum annuum L. (Jalapeño and Pusa Jwala)
Authors: Rathore Vikas , Sharma Piyush , Venugopal Arun Prasath , Nema Sudhir Kumar 
Published: September 2024

AbstractThe study investigates the efficacy of plasma-activated water (PAW) in preserving green chillies (jalapeño and pusa jwala) and compared it with various household fruits and vegetables cleaners’ solutions. PAW was prepared using a pencil plasma jet with air as the plasma forming gas. The results of visual analysis revealed that PAW-treated chillies maintain their fresh appearance even after 21 days, exhibiting significantly lower spoilage compared to control (ultrapure milli-Q water) and fruits and vegetables cleaners’ solutions. PAW demonstrated antimicrobial properties, effectively reducing microbial growth and spoilage on chillies over the storage period. Physical attributes, such as weight loss and firmness, are evaluated. It has been observed that PAW-treated chillies exhibit lower weight loss and higher firmness, indicating better membrane integrity and moisture retention. Microbial resistance was notably higher in PAW-treated chillies compared to control and when cleaning solutions were used. CIELAB color analysis revealed that PAW-treated chillies retain greenness, and color, freshness, outperforming control and cleaners. Sensory evaluation, including visual inspection, smell, taste, and touch, consistently favored PAW-treated chillies, emphasizing their superiority in terms of enhancement in shelf-life. Biochemical analysis revealed that PAW-treated chillies either maintain or show enhancement in nutritional attributes such as soluble sugar, protein, and ascorbic acid concentrations. Phenol concentration (antioxidant activity) remained stable across treatments. Overall, the study underscores the positive impact of PAW treatment on preserving the membrane integrity, antimicrobial resistance, sensory quality, and nutritional attributes of green chillies, making PAW an alternative for extending their shelf life.
Is gastronomy crucial for UNESCO sites’ tourists? An important exploratory Italian study
Authors: Garofalo Antonio , Palmieri Nadia , Boccia Flavio 
Published: September 2024

AbstractThe paper analyses the role of gastronomic experiences as potential tourist attractions for local development. The decision to focus on a particular UNESCO site, as the Carolino aqueduct, is based on a perceived knowledge gap regarding the lack of tourists for the Carolino aqueduct. The work is based on quantitative data collection among potential visitors of the aqueduct Carolino. Altogether, 840 valid questionnaires were collected a Partial Least Squares Structural Equation Modeling (PLS-SEM) was applied. Findings reveal that that people’s motivation, supplied food, prior knowledge and past experiences influence the gastronomic experiences. The gastronomic experiences in turn affect both satisfaction with the destination and destination loyalty. Thus, gastronomic experiences should be useful path to support the tourism in a UNESCO site, as the aqueduct Carolino. When discussing issues related to the cultural heritage, the question arises as to how should enhance the cultural heritage for tourism reasons. The results of this research demonstrate that gastronomic experiences are imperative to the success of cultural heritage tourism.
The vasoprotective role of IGF-1 signaling in the cerebral microcirculation: prevention of cerebral microhemorrhages in aging
Authors: Stankovics Levente , Ungvari Anna , Fekete Mónika , Nyul-Toth Adam , Mukli Peter , Patai Roland , Csik Boglarka , Gulej Rafal , Conley Shannon , Csiszar Anna , Toth Peter 
Published: September 2024

AbstractAging is closely associated with various cerebrovascular pathologies that significantly impact brain function, with cerebral small vessel disease (CSVD) being a major contributor to cognitive decline in the elderly. Consequences of CSVD include cerebral microhemorrhages (CMH), which are small intracerebral bleeds resulting from the rupture of microvessels. CMHs are prevalent in aging populations, affecting approximately 50% of individuals over 80, and are linked to increased risks of vascular cognitive impairment and dementia (VCID). Hypertension is a primary risk factor for CMHs. Vascular smooth muscle cells (VSMCs) adapt to hypertension by undergoing hypertrophy and producing extracellular matrix (ECM) components, which reinforce vessel walls. Myogenic autoregulation, which involves pressure-induced constriction, helps prevent excessive pressure from damaging the vulnerable microvasculature. However, aging impairs these adaptive mechanisms, weakening vessel walls and increasing susceptibility to damage. Insulin-like Growth Factor 1 (IGF-1) is crucial for vascular health, promoting VSMC hypertrophy, ECM production, and maintaining normal myogenic protection. IGF-1 also prevents microvascular senescence, reduces reactive oxygen species (ROS) production, and regulates matrix metalloproteinase (MMP) activity, which is vital for ECM remodeling and stabilization. IGF-1 deficiency, common in aging, compromises these protective mechanisms, increasing the risk of CMHs. This review explores the vasoprotective role of IGF-1 signaling in the cerebral microcirculation and its implications for preventing hypertension-induced CMHs in aging. Understanding and addressing the decline in IGF-1 signaling with age are crucial for maintaining cerebrovascular health and preventing hypertension-related vascular injuries in the aging population.
Subcutaneous edema segmentation on abdominal CT using multi-class labels and iterative annotation
Authors: Bhadra Sayantan , Liu Jianfei , Summers Ronald M. 
Published: September 2024

Abstract

Purpose:

Anasarca is a condition that results from organ dysfunctions, such as heart, kidney, or liver failure, characterized by the presence of edema throughout the body. The quantification of accumulated edema may have potential clinical benefits. This work focuses on accurately estimating the amount of edema non-invasively using abdominal CT scans, with minimal false positives. However, edema segmentation is challenging due to the complex appearance of edema and the lack of manually annotated volumes.

Methods:

We propose a weakly supervised approach for edema segmentation using initial edema labels from the current state-of-the-art method for edema segmentation (Intensity Prior), along with labels of surrounding tissues as anatomical priors. A multi-class 3D nnU-Net was employed as the segmentation network, and training was performed using an iterative annotation workflow.

Results:

We evaluated segmentation accuracy on a test set of 25 patients with edema. The average Dice Similarity Coefficient of the proposed method was similar to Intensity Prior (61.5% vs. 61.7%;

$$p=0.83$$

p
=
0.83

). However, the proposed method reduced the average False Positive Rate significantly, from 1.8% to 1.1% (

$$p<0.001$$

p
<
0.001

). Edema volumes computed using automated segmentation had a strong correlation with manual annotation (

$$R^2=0.87$$

R
2

=
0.87

).

Conclusion:

Weakly supervised learning using 3D multi-class labels and iterative annotation is an efficient way to perform high-quality edema segmentation with minimal false positives. Automated edema segmentation can produce edema volume estimates that are highly correlated with manual annotation. The proposed approach is promising for clinical applications to monitor anasarca using estimated edema volumes.