bluuebunny/crossref_metadata_2025_split huggingface dataset:
Specific depressive symptoms predict remission to aripiprazole augmentation in late‐life treatment resistant depression
Authors: Gebara Marie Anne , DiNapoli Elizabeth A. , Kasckow John , Karp Jordan F. , Blumberger Daniel M. , Lenze Eric J. , Mulsant Benoit H. , Reynolds Charles F. 
Published: October 2017

ObjectiveTo identify which specific depressive symptoms predict remission to aripiprazole augmentation in late‐life treatment resistant depression.MethodsThis is a secondary analysis of data from a late‐life treatment resistant depression trial examining the safety and efficacy of aripiprazole augmentation. Participants aged 60 and above were randomized to aripiprazole augmentation (N = 91) versus placebo (N = 90). The main outcome was depression remission. Clinical predictors included individual Montgomery‐Asberg Depression Rating Scale (MADRS) item scores categorized as symptomatic (scores >2) or nonsymptomatic (scores ≤2).ResultsThree MADRS items predicted depression remission with aripiprazole augmentation: symptomatic scores on sleep disturbance and nonsymptomatic scores on apparent sadness and inability to feel. The 2‐way and 3‐way interaction terms of these MADRS items were not significant predictors of remission; therefore, the models' ability to predict remission was not improved by combining the significant MADRS items.ConclusionsThe identification of specific depressive symptoms, which can be clinically assessed, can be used to inform treatment decisions. Older adults with treatment resistant depression that present with sleep disturbances, lack of apparent sadness, or lack of inability to feel should be considered for aripiprazole augmentation.
Synthesis, structural elucidation, and biological activity to organotin(IV) derivatives of (E)‐2,3‐bis(4‐chlorophenyl)‐2‐propenoic acid
Authors: Rehman Sadiq‐ur‐ , Choudhary Muhammad Aziz , Ahmad Zahoor , Mirza M. Aslam , Ali Saqib 
Published: October 2017

AbstractEight new organotin(IV) carboxylates of general formula RnSnL4‐n have been synthesized by the reaction of respective organotin(IV) oxide/chloride with stoichiometric amount of the ligand, (E)‐2,3‐bis(4‐chlorophenyl)‐2‐propenoic acid or its silver salt in dry toluene using Dean and Stark apparatus accordingly. The synthesized carboxylates were characterized using multinuclear (1H,13C,119Sn)NMR,FT‐IRspectroscopies and mass spectrometry in combination with the elemental analysis and melting point determination. The data reveal that tri‐ and diorganotin(IV) carboxylates adopt penta‐ and hexa‐coordination around tin moiety in solid states, respectively. All compounds were preliminary screened for antimicrobial, antifungal, and cytotoxicity studies, and some of the compounds exhibit promising results.
Social value and individual choice: The value of a choice‐based decision‐making process in a collectively funded health system
Authors: Espinoza Manuel Antonio , Manca Andrea , Claxton Karl , Sculpher Mark 
Published: October 2017

AbstractEvidence about cost‐effectiveness is increasingly being used to inform decisions about the funding of new technologies that are usually implemented as guidelines from centralized decision‐making bodies. However, there is also an increasing recognition for the role of patients in determining their preferred treatment option. This paper presents a method to estimate the value of implementing a choice‐based decision process using the cost‐effectiveness analysis toolbox. This value is estimated for 3 alternative scenarios. First, it compares centralized decisions, based on population average cost‐effectiveness, against a decision process based on patient choice. Second, it compares centralized decision based on patients' subgroups versus an individual choice‐based decision process. Third, it compares a centralized process based on average cost‐effectiveness against a choice‐based process where patients choose according to a different measure of outcome to that used by the centralized decision maker. The methods are applied to a case study for the management of acute coronary syndrome. It is concluded that implementing a choice‐based process of treatment allocation may be an option in collectively funded health systems. However, its value will depend on the specific health problem and the social values considered relevant to the health system.
Water level observations from unmanned aerial vehicles for improving estimates of surface water–groundwater interaction
Authors: Bandini Filippo , Butts Michael , Jacobsen Torsten Vammen , Bauer‐Gottwein Peter 
Published: October 2017

AbstractIntegrated hydrological models are usually calibrated against observations of river discharge and piezometric head in groundwater aquifers. Calibration of such models against spatially distributed observations of river water level can potentially improve their reliability and predictive skill. However, traditional river gauging stations are normally spaced too far apart to capture spatial patterns in the water surface, whereas spaceborne observations have limited spatial and temporal resolution. Unmanned aerial vehicles can retrieve river water level measurements, providing (a) high spatial resolution; (b) spatially continuous profiles along or across the water body, and (c) flexible timing of sampling. A semisynthetic study was conducted to analyse the value of the new unmanned aerial vehicle‐borne datatype for improving hydrological models, in particular estimates of groundwater–surface water (GW–SW) interaction. Mølleåen River (Denmark) and its catchment were simulated using an integrated hydrological model (MIKE 11–MIKE SHE). Calibration against distributed surface water levels using the Differential Evolution Adaptive Metropolis algorithm demonstrated a significant improvement in estimating spatial patterns and time series of GW–SW interaction. After water level calibration, the sharpness of the estimates of GW–SW time series improves by ~50% and root mean square error decreases by ~75% compared with those of a model calibrated against discharge only.
Human serum albumin: A modulator of cannabinoid drugs
Authors: Leboffe Loris , di Masi Alessandra , Trezza Viviana , Polticelli Fabio , Ascenzi Paolo 
Published: October 2017

AbstractThe endocannabinoid system is a unique neuromodulatory system that affects a wide range of biological processes and maintains the homeostasis in all mammal body systems. In recent years, several pharmacological tools to target endocannabinoid neurotransmission have been developed, including direct and indirect cannabinoid agonists and cannabinoid antagonists. Due to their hydrophobic nature, cannabinoid agonists and antagonists need to bind specific transporters to allow their distribution in body fluids. Human serum albumin (HSA), the most abundant plasma protein, is a key determinant of drug pharmacokinetics. As HSA binds both the endocannabinoid anandamide and the active ingredient of Cannabis sativa, Δ‐9‐tetrahydrocannabinol, we hypothesize that HSA can be the most important carrier of cannabinoid drugs. In silico docking observations strongly indicate that HSA avidly binds the indirect cannabinoid agonists URB597, AM5206, JZL184, JZL195, and AM404, the direct cannabinoid agonists WIN55,212-2 and CP55,940, and the prototypical cannabinoid antagonist/inverse agonist SR141716. Values of the free energy for cannabinoid drugs binding to HSA range between −5.4 kcal mol–1 and −10.9 kcal mol–1. Accounting for the HSA concentration in vivo (∼ 7.5 × 10–4 M), values of the free energy here determined suggest that the formation of the HSA:cannabinoid drug complexes may occur in vivo. Therefore, HSA appears to be an important determinant for cannabinoid efficacy and may guide the choice of the drug dose regimen to optimize drug efficacy and to avoid drug‐related toxicity. © 2017 IUBMB Life, 69(11):834–840, 2017.
A novel calcium‐accumulating peptide/gelatin in situ forming hydrogel for enhanced bone regeneration
Authors: Jo Beom Soo , Lee Yunki , Suh Jin Sook , Park Yoon Shin , Lee Hyun Jung , Lee Jue‐Yeon , Cho Jaejin , Lee Gene , Chung Chong Pyoung , Park Ki Dong , Park Yoon Jeong 
Published: October 2017

AbstractBioactive agents, including proteins and peptides, can be loaded into hydrogels to improve bone regenerative capacity with their controlled release. However, the current loading method has focused on physical mixing, which has limited release control. Therefore, alternative conjugation of bioactive agents with hydrogels is highly recommended. Direct chemical conjugation of synthetic peptides containing a functional moiety with a hydrogel would be ideal. Here, we synthesized a bioactive calcium accumulating peptide (CAP) containing a collagen binding motif, which can induce osteogenic differentiation. A tyrosine residue in CAP was used to directly chemically conjugate the peptide with a gelatin‐based enzymatically crosslinked hydroxyphenyl propionic acid hydrogel under H2O2/Horse radish peroxidase conditions. To test the acceleration of bone formation, human periodontal ligament stem cells (PDLSCs) were loaded into a chemically conjugated CAP hydrogel. The CAP hydrogel induced bone mineralization around the PDLSCs and increased osteogenic marker expressions in vitro. It also recovered a bone layer in a calvarial defect 4 weeks postimplantation. In summary, an injectable CAP hydrogel scaffold system was developed as a potentially useful engineered microenvironment to enhance bone restoration, and it could be utilized as a vehicle for bioactive delivery of stem cells in tissue regenerative therapy. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 531–542, 2018.
Direct surface modification of metallic biomaterials via tyrosine oxidation aiming to accelerate the re‐endothelialization of vascular stents
Authors: Kakinoki Sachiro , Takasaki Kensuke , Mahara Atsushi , Ehashi Tomo , Hirano Yoshiaki , Yamaoka Tetsuji 
Published: October 2017

AbstractRapid in‐situ re‐endothelialization of coronary stents is one of the most effective approaches to inhibit late thrombosis and restenosis. Strut surfaces allowing excellent adhesion and migration of endothelial cells and endothelial progenitor cells may accelerate in‐situ re‐endothelialization. Here, a well‐known endothelial cell adhesive peptide, Arg‐Glu‐Asp‐Val (REDV), was directly immobilized onto metallic surfaces by means of single‐step tyrosine oxidation with copper chloride (II) and hydrogen peroxide, which we recently reported as a new biomaterial modification technique. REDV immobilization on a 316L stainless steel plate improved endothelial cell adhesion and effectively suppressed platelet adhesion in vitro. In addition, a Co‐Cr stent immobilized with Ac‐Tyr‐Gly‐Gly‐Gly‐Arg‐Glu‐Asp‐Val (Y‐REDV) was implanted into a rabbit abdominal aorta. On 7 days postimplantation, 80% of the strut surface of the Y‐REDV‐immobilized stent was covered by a thin neointimal layer and was similar in appearance to native endothelium. Restenosis and late thrombosis were not observed in the Y‐REDV‐immobilized stent for 42 days. These findings suggest that direct immobilization of Y‐REDV peptide onto metallic biomaterials by tyrosine oxidation is effective for promoting in‐situ re‐endothelialization in vascular stents. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 491–499, 2018.
Antibiotic‐eluting orthopedic device to prevent early implant associated infections: Efficacy, biocompatibility and biodistribution studies in an ovine model
Authors: Gimeno Marina , Pinczowski Pedro , Mendoza Gracia , Asín Javier , Vázquez Francisco J. , Vispe Eugenio , García‐Álvarez Felícito , Pérez Marta , Santamaría Jesús , Arruebo Manuel , Luján Lluís 
Published: October 2017

AbstractInfection of orthopedic devices is a major complication in the postsurgical period generating important health issues and economic consequences. Prevention strategies could be based on local release of antibiotics from the orthopedic device itself to avoid adhesion and growth of bacteria. The purpose of this work is to demonstrate the efficiency to prevent these infections by a cefazolin‐eluting, perforated stainless steel implant in an in vivo ovine model. The device was placed in the tibia of sheep, one group receiving cefazolin‐loaded implants whereas the control group received empty implants. All implants were experimentally infected by direct inoculation of Staphylococcus aureus ATCC 6538. In vitro cytotoxicological studies were also performed to check the effect of antibiotic on cell viability, integrity, and cycle. Results showed that sheep receiving cefazolin‐loaded devices were able to avoid implant‐associated infections, with normal tissue healing process. The antibiotic release followed a local concentric pattern as demonstrated by high‐performance liquid chromatography detection in tissues. The in vitro results indicate the lack of relevant cytotoxic effects for the maximum antibiotic concentration released by the device. These results demonstrate the efficiency and safety of cefazolin‐eluting implants in an ovine model to prevent early postsurgical infections of orthopedic devices. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1976–1986, 2018.
Biophysical interactions between pancreatic cancer cells and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering
Authors: Matta‐Domjan Brigitta , King Alice , Totti Stella , Matta Csaba , Dover George , Martinez Patricia , Zakhidov Anvar , La Ragione Roberto , Macedo Hugo , Jurewicz Izabela , Dalton Alan , Velliou Eirini G. 
Published: October 2017

AbstractNovel synthetic biomaterials able to support direct tissue growth and retain cellular phenotypical properties are promising building blocks for the development of tissue engineering platforms for accurate and fast therapy screening for cancer. The aim of this study is to validate an aligned, pristine multi‐walled carbon nanotube (CNT) platform for in vitro studies of pancreatic cancer as a systematic understanding of interactions between cells and these CNT substrates is lacking. Our results demonstrate that our CNT scaffolds—which are easily tuneable to form sheets/fibers—support growth, proliferation, and spatial organization of pancreatic cancer cells, indicating their great potential in cancer tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1637–1644, 2018.
Ciprofloxacin‐isatin‐1H‐1,2,3‐triazole Hybrids: Design, Synthesis, and in vitro Anti‐tubercular Activity against M. tuberculosis
Authors: Xu Zhi , Lv Zao‐Sheng , Song Xu‐Feng , Qiang Min 
Published: October 2017

A new set of ciprofloxacin (CPFX)‐isatin‐1H‐1,2,3‐triazole hybrids 6a–l with greater lipophilicity compared with the parent CPFX was designed, synthesized, and assessed for their in vitro anti‐mycobacterial activity against Mycobacterium tuberculosis (MTB) H37Rv as well as cytotoxicity in VERO cell line. The preliminary results showed that all hybrids (MIC: 0.39–50 μg/mL) exhibited promising activities against MTB H37Rv, and six of them (MIC: 0.39–1.56 μg/mL) were more active than the parent CPFX (MIC: 3.12 μg/mL). In particular, the most active conjugate 6h (MIC: 0.39 μg/mL) was comparable with RIF (MIC: 0.39 μg/mL), and eight times more potent than CPFX. All conjugates (CC50: 4–64 μg/mL) were more toxic than the parent (CC50: 128 μg/mL) in VERO cell lines, and the most active hybrids, which also displayed the highest cytotoxicity, should be further optimized.
Effect of mechanical strain on the pluripotency of murine embryonic stem cells seeded in a collagen‐I scaffold
Authors: Hazenbiller Olesja , Nasr Saghar , Krawetz Roman J. , Duncan Neil A. 
Published: October 2017

ABSTRACTThe use of embryonic stem cells (ESC) in regenerative medicine is restricted due to the possibility of tumorigenicity after inefficient or incomplete differentiation. Studies from our group, and others, suggest that mechanical stimuli may have a suppressive effect on the pluripotency/tumorigenesis of murine ESC (mESC). Furthermore, we have demonstrated that mESC seeded in a type I collagen scaffold, and transplanted into a murine bone fracture model, demonstrated repair without tumor formation. However, it remains unknown if mechanical factors were involved in blocking tumorigenicity of the mESC. Therefore, the aims of the current study were: (i) to characterize the mechanical environment within the transplanted construct (mESC‐Col I) in an in vivo murine fracture model using computational analyses; and (ii) to reproduce this mechanical environment in vitro to elucidate the role of these mechanical factors on mESC pluripotent gene expression. It was predicted that the mESC‐Col I construct was subjected to an average octahedral shear strain of ∼3.8% and a compressive strain of ∼3.1% within the fracture in vivo when the murine tibia was subjected to an axial compression load of 4 N (1 Hz). When a similar strain environment was replicated experimentally in vitro, the expression patterns of marker genes for pluripotency (Oct 4, Sox 2, Nanog, Rex 1, and oncogene ERas) were significantly down‐regulated. This suggests that the local micro‐mechanical environment within the fracture site in vivo may be involved in regulating stem cell fate after transplantation, and that these physical factors should be considered when developing regenerative medicine strategies. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:799–807, 2018.
Current and novel injectable hydrogels to treat focal chondral lesions: Properties and applicability
Authors: Pascual‐Garrido Cecilia , Rodriguez‐Fontan Francisco , Aisenbrey Elizabeth A. , Payne Karin A. , Chahla Jorge , Goodrich Laurie R. , Bryant Stephanie J. 
Published: October 2017

ABSTRACTFocal chondral lesions and early osteoarthritis (OA) are responsible for progressive joint pain and disability in millions of people worldwide, yet there is currently no surgical joint preservation treatment available to fully restore the long term functionality of cartilage. Limitations of current treatments for cartilage defects have prompted the field of cartilage tissue engineering, which seeks to integrate engineering and biological principles to promote the growth of new cartilage to replace damaged tissue. Toward improving cartilage repair, hydrogel design has advanced in recent years to improve their utility. Injectable hydrogels have emerged as a promising scaffold due to their wide range of properties, the ability to encapsulate cells within the material, and their ability to provide cues for cell differentiation. Some of these advances include the development of improved control over in situ gelation (e.g., light), new techniques to process hydrogels (e.g., multi‐layers), and better incorporation of biological signals (e.g., immobilization, controlled release, and tethering). This review summarises the innovative approaches to engineer injectable hydrogels toward cartilage repair. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:64–75, 2018.
Flash autoclave settings may influence eradication but not presence of well‐established biofilms on orthopaedic implant material
Authors: Williams Dustin L. , Taylor Nicholas B. , Epperson Richard T. , Rothberg David L. 
Published: October 2017

ABSTRACTFlash autoclaving is one of the most frequently utilized methods of sterilizing devices, implants or other materials. For a number of decades, it has been common practice for surgeons to remove implantable devices, flash autoclave and then reimplant them in a patient. Data have not yet indicated the potential for biofilms to survive or remain on the surface of orthopaedic‐relevant materials following flash autoclave. In this study, monomicrobial and polymicrobial biofilms were grown on the surface of clinically relevant titanium materials and exposed to flash autoclave settings that included varying times and temperatures. Data indicated that when the sterilization and control temperatures of an autoclave were the same, biofilms were able to survive flash autoclaving that was performed for a short duration. Higher temperature and increased duration rendered biofilms non‐viable, but none of the autoclave settings had the ability to remove or disperse the presence of biofilms from the titanium surfaces. These findings may be beneficial for facilities, clinics, or hospitals to consider if biofilms are suspected to be present on materials or devices, in particular implants that have had associated infection and are considered for re‐implantation. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1543–1550, 2018.
Oncologic results and quality of life in patients with squamous cell carcinoma of hypopharynx after transoral laser microsurgery
Authors: Hung Li‐Ting , Huang Hsin‐I , Wang Ling‐Wei , Yang Muh‐Hwa , Chu Pen‐Yuan 
Published: October 2017

ObjectiveTransoral laser microsurgery (TLM) is an alternative method for organ preservation in squamous cell carcinoma of hypopharynx (HPSCC). The purpose of this study was to analyze the oncologic results and quality of life (QOL) in HPSCC patients after TLM.MethodsForty‐six patients who underwent TLM were included, 34 of them had QOL evaluations. The QOL analyses were measured with EORTC QLQ‐C‐30, QLQ‐H&N35, VHI‐30, and MDADI at least 6 months postoperatively.ResultsMost patients were male (96%) with a median age of 60 years. Four patients (9%) were at the T1 category, 24 (52%) at T2, 15 (33%) at T3, and 3 (7%) at T4. Twenty‐nine patients (63%) had cervical lymph node metastases and 26 (57%) received postoperative radiotherapy. With a median follow‐up of 61 months for all patients, 18 (39%) had tumor recurrence, including 4 local, 7 regional, and 7 distant. The 5‐year overall and disease‐specific survival (DSS) rates were 59% and 77%, respectively. The 5‐year laryngeal preservation rate was 89%. Most patients had satisfactory QOLs.ConclusionIn early and selective moderately advanced HPSCC, TLM can achieve optimal oncologic results and satisfactory QOL. Lasers Surg. Med. 50:117–124, 2018.   © 2017 Wiley Periodicals, Inc.
Nickel‐Salen Type Polymers as Cathode Materials for Rechargeable Lithium Batteries
Authors: Eliseeva Svetlana N. , Alekseeva Elena V. , Vereshchagin Anatoliy A. , Volkov Alexey I. , Vlasov Petr S. , Konev Alexander S. , Levin Oleg V. 
Published: October 2017

AbstractThe nickel salen‐type redox polymers represent an interesting class of organometallic polymers frequently used in hybrid supercapacitor electrodes as thin films and carbon material composites. However, the suitability of these compounds for application as electrode materials for rechargeable batteries has not yet been tested. In this study, redox processes in monocomponent electrodes based on a series of nickel salen‐type redox polymers are investigated in 1mLiPF6in 1:1 ethylene carbonate (EC)/diethyl carbonate (DEC) electrolyte in a Li‐ion battery. The oxidation potentials for polymer complexes of nickel exceed 3.5 V versus Li/Li+, which enhances specific energy. It is found that introduction of a proper substituent in the phenyl ring of the ligand allows to fabricate additive‐free electrodes which demonstrate high charge/discharge rate performance with the capacity on discharge at 10Cbeing up to 73% of the capacity obtained at discharge at 1C, which corresponds to maximum power of 2.6 kW kg−1.