bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Phase III Trial of Standard Therapy Plus Low Molecular Weight Heparin in Patients With Lung Cancer: FRAGMATIC Trial
Authors: Macbeth Fergus , Noble Simon , Evans Jessica , Ahmed Sheikh , Cohen David , Hood Kerenza , Knoyle Dana , Linnane Seamus , Longo Mirella , Moore Barbara , Woll Penella J. , Appel Wiebke , Dickson Jeanette , Ferry David , Brammer Caroline , Griffiths Gareth 
Published: December 2015

Purpose Venous thromboembolism (VTE) is common in cancer patients. Evidence has suggested that low molecular weight heparin (LMWH) might improve survival in patients with cancer by preventing both VTE and the progression of metastases. No trial in a single cancer type has been powered to demonstrate a clinically significant survival difference. The aim of this trial was to investigate this question in patients with lung cancer. Patients and Methods We conducted a multicenter, open-label, randomized trial to evaluate the addition of a primary prophylactic dose of LMWH for 24 weeks to standard treatment in patients with newly diagnosed lung cancer of any stage and histology. The primary outcome was 1-year survival. Secondary outcomes included metastasis-free survival, VTE-free survival, toxicity, and quality of life. Results For this trial, 2,202 patients were randomly assigned to the two treatment arms over 4 years. The trial did not reach its intended number of events for the primary analysis (2,047 deaths), and data were analyzed after 2,013 deaths after discussion with the independent data monitoring committee. There was no evidence of a difference in overall or metastasis-free survival between the two arms (hazard ratio [HR], 1.01; 95% CI, 0.93 to 1.10; P = .814; and HR, 0.99; 95% CI, 0.91 to 1.08; P = .864, respectively). There was a reduction in the risk of VTE from 9.7% to 5.5% (HR, 0.57; 95% CI, 0.42 to 0.79; P = .001) in the LMWH arm and no difference in major bleeding events but evidence of an increase in the composite of major and clinically relevant nonmajor bleeding in the LMWH arm. Conclusion LMWH did not improve overall survival in the patients with lung cancer in this trial. A significant reduction in VTE is associated with an increase in clinically relevant nonmajor bleeding. Strategies to target those at greatest risk of VTE are warranted.
Feel your stride and find your preferred running speed
Authors: Lussiana Thibault , Gindre Cyrille 
Published: December 2015

ABSTRACTThere is considerable inter-individual variability in self-selected intensity or running speed. Metabolic cost per distance has been recognized as a determinant of this personal choice. As biomechanical parameters have been connected to metabolic cost, and as different running patterns exist, we can question their possible determinant roles in self-selected speed. We examined the self-selected speed of 15 terrestrial and 16 aerial runners, with comparable characteristics, on a 400 m track and assessed biomechanical parameters and ratings of pleasure/displeasure. The results revealed that aerial runners choose greater speeds associated with shorter contact time, longer flight time, and higher leg stiffness than terrestrial runners. Pleasure was negatively correlated with contact time and positively with leg stiffness in aerial runners and was negatively correlated with flight time in terrestrial runners. We propose the existence of an optimization system allowing the connection of running patterns at running speeds, and feelings of pleasure or displeasure.
PTP1B triggers integrin-mediated repression of myosin activity and modulates cell contractility
Authors: González Wusener Ana E. , González Ángela , Nakamura Fumihiko , Arregui Carlos O. 
Published: December 2015

ABSTRACT
Cell contractility and migration by integrins depends on precise regulation of protein tyrosine kinase and Rho-family GTPase activities in specific spatiotemporal patterns. Here we show that protein tyrosine phosphatase PTP1B cooperates with β3 integrin to activate the Src/FAK signalling pathway which represses RhoA-myosin-dependent contractility. Using PTP1B null (KO) cells and PTP1B reconstituted (WT) cells, we determined that some early steps following cell adhesion to fibronectin and vitronectin occurred robustly in WT cells, including aggregation of β3 integrins and adaptor proteins, and activation of Src/FAK-dependent signalling at small puncta in a lamellipodium. However, these events were significantly impaired in KO cells. We established that cytoskeletal strain and cell contractility was highly enhanced at the periphery of KO cells compared to WT cells. Inhibition of the Src/FAK signalling pathway or expression of constitutive active RhoA in WT cells induced a KO cell phenotype. Conversely, expression of constitutive active Src or myosin inhibition in KO cells restored the WT phenotype. We propose that this novel function of PTP1B stimulates permissive conditions for adhesion and lamellipodium assembly at the protruding edge during cell spreading and migration.
Tissue-specific tagging of endogenous loci inDrosophila melanogaster
Authors: Koles Kate , Yeh Anna R. , Rodal Avital A. 
Published: December 2015

ABSTRACTFluorescent protein tags have revolutionized cell and developmental biology, and in combination with binary expression systems they enable diverse tissue-specific studies of protein function. However these binary expression systems often do not recapitulate endogenous protein expression levels, localization, binding partners and/or developmental windows of gene expression. To address these limitations, we have developed a method called T-STEP (tissue-specific tagging of endogenous proteins) that allows endogenous loci to be tagged in a tissue specific manner. T-STEP uses a combination of efficient CRISPR/Cas9-enhanced gene targeting and tissue-specific recombinase-mediated tag swapping to temporally and spatially label endogenous proteins. We have employed this method to GFP tag OCRL (a phosphoinositide-5-phosphatase in the endocytic pathway) and Vps35 (a Parkinson's disease-implicated component of the endosomal retromer complex) in diverse Drosophila tissues including neurons, glia, muscles and hemocytes. Selective tagging of endogenous proteins allows, for the first time, cell type-specific live imaging and proteomics in complex tissues.
Drosophila p120-catenin is crucial for endocytosis of the dynamic E-cadherin–Bazooka complex
Authors: Bulgakova Natalia A. , Brown Nicholas H. 
Published: December 2015

ABSTRACT
The intracellular functions of classical cadherins are mediated through the direct binding of two catenins: β-catenin and p120-catenin (also known as CTNND1 in vertebrates, and p120ctn in Drosophila). Whereas β-catenin is crucial for cadherin function, the role of p120-catenin is less clear and appears to vary between organisms. We show here that p120-catenin has a conserved role in regulating the endocytosis of cadherins, but that its ancestral role might have been to promote endocytosis, followed by the acquisition of a new inhibitory role in vertebrates. In Drosophila, p120-catenin facilitates endocytosis of the dynamic E-cadherin–Bazooka subcomplex, which is followed by its recycling. The absence of p120-catenin stabilises this subcomplex at the membrane, reducing the ability of cells to exchange neighbours in embryos and expanding cell–cell contacts in imaginal discs.
The perspective of logotheory –help in understanding humans searching for meaning.
Authors: Salamon Anna 
Published: December 2015

CelInspiracją do napisania artykułu była rozmowa autorki z mężczyzną, który określa siebie jako osobę homoseksualną. Równocześnie istotną dla niego wartością jest relacja z Bogiem, rozumiana zgodnie z doktryną wyznawanej przez niego wiary. Po wysłuchaniu opowieści o życiu badanego, autorka poszukuje odpowiedzi na pytanie, jaka perspektywa teoretyczna pomoże zbliżyć się do rozumienia jego doświadczenia, szanując różne jego aspekty.MetodaAutorka dokonuje hermeneutycznej refleksji nad treścią usłyszanej historii oraz pracami autorstwa V.E. Frankla.WynikiDochodzi do wniosku, że logoteoria może w wystarczającym stopniu spełnić oczekiwania dotyczące pomocy w rozumieniu doświadczenia badanego. Perspektywa ta ukazuje wyjątkowy i indywidualny charakter jego doświadczenia. W różnych okresach życia doświadczał on napięcia pomiędzy przeżywaniem swojej wiary a pragnieniami związanymi ze swoją homoseksualnością. W kontekście logoteorii można rozpatrywać to napięcie jako przestrzeń poszukiwania osobistego sensu.WnioskiLogoteoria odnosząc się do różnych obszarów egzystencji człowieka, podkreśla wagę poszukiwania przez niego sensu. Proces ten jest nieodłącznie związany z pewnego rodzaju napięciem, czyli noodynamiką. Perspektywa logoteorii wiąże się z postawą szacunku wobec doświadczenia odnoszącego się do sfery duchowej, chroniąc przed pułapką redukcjonizmu ontologicznego.
Between care and violence – about relation with the patient in medical care
Authors: Wójcik-Krzemień Anna 
Published: December 2015

CelCelem przedstawionego artykułu jest refleksja nad znaczeniem słowa „opieka” oraz nad rolą relacji w opiece. Artykuł zrodził się z doświadczeń autorki pracującej w Zakładzie Opiekuńczo-Leczniczym.MetodaZastosowana metoda to obserwacja uczestnicząca.WynikiPrzedstawiono próby towarzyszenia oraz dialogi z pacjentami, aby unaocznić twierdzenie, że relacja jest nieodłączną częścią opieki. Pacjent jest podmiotem (nie przedmiotem) opieki.WnioskiTroska o relację powinna być imperatywem dla osób sprawujących opiekę. Opieka jest odpowiedzią na chorobę, która spada na pacjenta, a którą ten interpretuje w kategorii skierowanej na niego przemocy. Gest medyczny zawiera w sobie usprawiedliwioną przemoc służącą walce z chorobą. „Zarażeniu” przemocą może też ulec relacja z pacjentem. Etyka obecności: wrażliwość na różne formy ekspresji intymności drugiego, przy jednoczesnym zachowaniu powściągliwości, wskazuje drogę do tego, by chronić pacjenta przed niepotrzebną, dodatkową przemocą w opiece. Obecność i słuchanie, stanowiące zarazem podstawowe aspekty towarzyszenia, umożliwiają pacjentowi doznanie gościnności w relacji, tak bardzo upragnionej przez chorego w jego doświadczeniu granicznej sytuacji cierpienia (i śmierci).
Clinical Background of Attendance by Patient's Family during Home Medical Care Visits
Authors: Kimura Takuma , Imanaga Teruhiko , Matsuzaki Makoto , Akahoshi Tohru 
Published: December 2015

Background: In home medical care settings, some patients' families always attend provider visits, and others only do so when needed. The clinical background behind this difference is not well defined.Methods: A cross‐sectional mail survey of families of Japanese patients who had previously received home medical care, asking whether the family had always been present the patient during home healthcare visits and their reasons. Survey results were analyzed with a multivariable adjusted logistic regression model based on the explanatory variables, for aspects related to the family's attendance at provider visits.Results: Among the 271 families contacted, 190 families who finally met the selection criteria were divided into two groups : 155 families (81.6%) who had always been present with the patient ; and 35 families (18.4%) who had done so only when needed. Constant attendance by family members was significantly associated with the level of care required (odds ratio [OR] : 1.40, 95% confidence interval [CI] : 1.05–1.89, p = 0.02) and age of the primary caregiver (OR : 1.05, 95% CI : 1.02–1.09, p = 0.03). However, when the family had difficulty communicating with the provider owing to the patient's presence, families tended not to be present during visits by providers (OR : 0.41, 95% CI : 0.17–1.02, p = 0.06).Conclusions: In home medical care settings, visiting healthcare providers should bear in mind that if the family is not always present with the patient, there is a possibility that the family is experiencing difficulty communicating with the provider owing to the patient's presence.
Weakness and Low Lean Mass in Women With Hip Fracture: Prevalence According to the FNIH Criteria and Association With the Short-Term Functional Recovery
Authors: Di Monaco Marco , Castiglioni Carlotta 
Published: December 2015

Background and Purpose:
People with hip fracture commonly have low muscle mass, reduced muscle strength, limited mobility, and limited ability to function in activities of daily living. Our aim was to assess the role of grip strength and appendicular lean mass (aLM) to predict the short-term functional recovery in women with hip fracture. For both strength and aLM, we focused on the cutoff points recently released by the Foundation for the National Institutes of Health (FNIH).

Methods:
In this short-term prospective observational study, we investigated 138 white women consecutively admitted to a rehabilitation hospital because of their first hip fracture. We measured aLM by dual-energy x-ray absorptiometry, grip strength with a hand dynamometer, and body mass index (BMI) at a median of 18 days after hip fracture occurrence. Functional autonomy was assessed by the Barthel index at the end of the rehabilitation course.

Results:
Fifty-five of the 138 women (40%; 95% confidence interval [CI], 32%-48%) had a handgrip strength less than 16 kg, whereas 33 (24%; 95% CI, 17%-31%) had a handgrip strength/BMI less than 0.56. In both cases, the weak women had Barthel index scores significantly lower than the nonweak women (P ≤ .001). One hundred eighteen of the 138 women (86%; 95% CI, 80%-91%) had an aLM less than 15.02 kg, whereas 65 (48%; 95% CI, 39%-56%) had an aLM/BMI less than 0.512. In both cases the Barthel index scores were nonsignificantly different between the women whose aLM indexes were either below or above the cutoff points.

Conclusions:
Categorization according to the FNIH cutoff points for weakness significantly predicted the functional outcome in women with hip fracture, whereas categorization for aLM did not. Adjustments for BMI significantly changed the prevalence of either weakness or low aLM, but did not materially change their predictive roles.
Kinesiology Tape or Compression Sleeve Applied to the Thigh Does Not Improve Balance or Muscle Activation Before or Following Fatigue
Authors: Cavanaugh M. Tyler , Quigley Patrick J. , Hodgson Daniel D. , Reid Jonathan C. , Behm David G. 
Published: December 2015

AbstractCavanaugh, MT, Quigley, PJ, Hodgson, DD, Reid, JC, and Behm, DG. Kinesiology tape or compression sleeve applied to the thigh does not improve balance or muscle activation before or following fatigue.J Strength Cond Res30(7): 1992–2000, 2016—Compression sleeves (CS) and kinesiology tape (KT) are purported to enhance proprioception, however, there is substantial conflict in the literature. Because the beneficial effects of CS and KT are more evident in the literature with recovery, the objective of this study was to examine the effects of CS and KT on balance under acute nonfatigued and postfatigued conditions. Using a within-subject, repeated-measures design, 12 university participants (5 females and 7 males) performed in a random order CS, KT, and Control conditions. Two trials of each test were conducted before the application of CS or KT (pretest 1), immediately after the application (pretest 2), with posttests at 1 and 10 minutes after 4 sets of unilateral Bulgarian squats to failure (1 minute rest between sets). Tests included a Y balance test (measures: distance reached by nondominant foot in anterior, posterior lateral, and posterior medial directions) and drop jump landing balance test from a 50-cm platform (measures: ground reaction force, electromyography, and center of pressure). The fatigue protocol induced 25.3% decrease in unilateral squat repetitions from set 1 to set 4. There were no significant condition main effects or interactions for any balance measure or EMG before or after fatigue. In conclusion, independent of fatigue, there was no significant effect of CS or KT on balance outcomes immediately and up to 10 minutes following the fatiguing intervention. Thus, nonfatigued or muscles weakened by fatigue did not benefit from CS and KT application.
Acute Effects of Different Methods of Stretching and Specific Warm-ups on Muscle Architecture and Strength Performance
Authors: Sá Marcos A. , Matta Thiago T. , Carneiro Simone P. , Araujo Carolina O. , Novaes Jefferson S. , Oliveira Liliam F. 
Published: December 2015

Abstract
Sá, MA, Matta, TT, Carneiro, SP, Araujo, CO, Novaes, JS, and Oliveira, LF. Acute effects of different methods of stretching and specific warm-ups on muscle architecture and strength performance. J Strength Cond Res 30(8): 2324–2329, 2016—The purpose of the study was to investigate the acute effects of 2 stretching interventions, proprioceptive neuromuscular facilitation (PNF) and passive static stretching (PSS), and a specific warm-up (SW) on the strength and architecture of the vastus laterallis and biceps femoris muscles in a subsequent performance on a strength training session (STS). Musculoskeletal ultrasound images were acquired from 9 men before and immediately after stretchings or a SW, and 10 minutes after a STS. The STS consisted of the following exercises: leg extension, leg curl, leg press, and hack machine squat. The PNF resulted in lower performance for all situations. The PSS and SW improved performance for the leg press compared with the PNF and controls (CSs). For the hack machine squat, SWs resulted in higher performance than stretching conditions. The vastus lateralis muscle fascicle length (FL) increases after a STS for PNF. The biceps femoris muscle showed a higher pennation angle 10 minutes after the STS for PSS; the FL increases immediately after PSS and then decreases 10 minutes after the STS for PSS. As per our results, the SWs should be performed before STSs, whereas PNF stretching should not be prescribed because this condition impairs subsequent performance. These results may assist health professionals in prescribing resistance training.
Taste Bud-Derived BDNF Is Required to Maintain Normal Amounts of Innervation to Adult Taste Buds
Authors: Meng Lingbin , Ohman-Gault Lisa , Ma Liqun , Krimm Robin F. 
Published: December 2015

AbstractGustatory neurons transmit chemical information from taste receptor cells, which reside in taste buds in the oral cavity, to the brain. As adult taste receptor cells are renewed at a constant rate, nerve fibers must reconnect with new taste receptor cells as they arise. Therefore, the maintenance of gustatory innervation to the taste bud is an active process. Understanding how this process is regulated is a fundamental concern of gustatory system biology. We speculated that because brain-derived neurotrophic factor (BDNF) is required for taste bud innervation during development, it might function to maintain innervation during adulthood. If so, taste buds should lose innervation whenBdnfis deleted in adult mice. To test this idea, we first removedBdnffrom all cells in adulthood using transgenic mice with inducible CreERT2 under the control of the Ubiquitin promoter. WhenBdnfwas removed, approximately one-half of the innervation to taste buds was lost, and taste buds became smaller because of the loss of taste bud cells. Individual taste buds varied in the amount of innervation each lost, and those that lost the most innervation also lost the most taste bud cells. We then tested the idea that that the taste bud was the source of this BDNF by reducingBdnflevels specifically in the lingual epithelium and taste buds. Taste buds were confirmed as the source of BDNF regulating innervation. We conclude that BDNF expressed in taste receptor cells is required to maintain normal levels of innervation in adulthood.
Inkjet-printed quantum dot-based sensor for structural health monitoring
Authors: Hartwig Melinda , Ortlepp Franz , Möbius Martin , Martin Jörg , Otto Thomas , Geßner Thomas , Baumann Reinhard R. 
Published: December 2015

ABSTRACTA sensor which detects mechanical stresses and stores the position and the strength of these loads by color change of embedded quantum dots (QDs) is presented. The top and bottom electrodes of the sensor are inkjet-printed which leads to a fast and accurate deposition of thin (approx. 50 - 300 nm) and conductive layers. The used silver and poly(3,4-ethylenedioxythio-phene) polystyrene sulfonate (PEDOT:PSS) inks are optimized in terms of printability and opportunities of functionality forming without influencing the active layer of the sensor. The active layer of the sensor is spin-coated and consists of the QDs embedded in semi-conducting poly(9-vinylcarba-zole) (PVK). The hole transport characteristic of PVK and the band level alignment of the used materials ensures the preferred injection of only one type of charge carrier into the QDs. As a result the mechanical stress is visualized by a decreasing in photoluminescence (PL) of the QDs.
Editorial
Authors: Leite José Yvan P. 
Published: December 2015

Este volume publica resultados da área de tecnologia mineral, em particular do tradicional evento da área de tecnologia mineral que iniciou seu primeiro encontro em 1973 no Rio de Janeiro e organizado pela COPPE – Instituto Alberto Luiz Coimbra de Pós-Graduação e Pesquisa de Engenharia, da Universidade Federal do Rio de Janeiro (UFRJ) e denominado de Encontro Nacional de Tratamento de Minérios.Este periódico em 2013, durante realização do XXV Encontro Nacional de Tratamento de Minérios e Metalurgia Extrativa (ENTMME) e VIII Meeting of the Southern Hemisphere on Mineral Technology (MSHMT), em Goiânia/GO, coordenado pelo prof. André Silva da Universidade Federal de Goiás, celebrou uma parceria para a publicação de uma edição especial, com artigos do evento, os quais foram publicados no Vol. 3 de 2014 - http://www2.ifrn.edu.br/ojs/index.php/HOLOS/issue/view/63Este entendimento foi mantido com a organização do XXVI ENTMME, que foi realizado em Poços de Caldas/MG e coordenado pelos professores Maurício Bergerman (Universidade de São Paulo - USP) e Daniela Horta (Universidade Federal de Alfenas - UNIFAL).A importância da mineração no país justifica uma edição para ampliar a difusão neste campo, em particular o elevado impacto que esta área tem no PIB brasileiro e sua disseminação nos vários estados brasileiros. O recente desastre sócio-ambiental provocado pelo rompimento de barragem de rejeitos da Samarco, em Mariana/MG, coloca em evidência uma face negativa da mineração. O tema merece aprofundamento da comunidade acadêmica e este periódico fomentará uma edição especial em 2016 para discutir o tema.É importante compartilhar que o periódico passa a integrar a base Web of Science da Thomson Reuters, que pela importância amplia a visibilidade dos artigos publicados por estes lados do hemisfério sul.Nesta edição são publicados 21 artigos com contribuições nas áreas de caracterização tecnológica, cominuição, simulação, concentração gravítica, flotação, espessamento e briquetagem aplicado à agricultura.Externamos nossos agradecimentos aos novos integrantes do Conselho Editorial, os pesquisadores, Christos Roumpos (Technical University of Crete, Grécia), Francisco das Chagas Silva Sousa (Instituto Federal do Rio Grande do Norte, Brasil) e Francisco Manoel dos Santos Garrido (Universidade Federal do Rio de Janeiro, Brasil). Que nos engradeça do espírito público para compartilhar conhecimentos e ampliar horizontes que fortaleça a política científica difundida neste periódico.Esta editoria expressa reconhecimento e agradecimento à comissão organizadora do XXVI ENTMME pela realização de um excelente evento, por disponibilizar espaço para divulgação do periódico e pelo acolhimento em Poços de Caldas.Aos autores e pareceristas ad hoc, a editoria agradece de forma especial a confiança neste periódico.Por fim, convido àqueles com interesse em Tecnologia Mineral a prospectar artigos de interesse.Boas Festas e um Sempre Feliz 2016! Natal, 24 de dezembro de 2015. Prof. José Yvan Pereira Leite