bluuebunny/crossref_metadata_2025_split huggingface dataset:
Das abdominale Aortenaneurysma
Authors: Trenner Matthias , Reutersberg Benedikt , Busch Albert , Stoklasa Kerstin , Eckstein Hans-Henning 
Published: July 2017

ZUSAMMENFASSUNGDas abdominale Aortenaneurysma (AAA) ist das häufigste Aneurysma der großen Arterien. Die offen-chirurgische oder endovaskuläre Therapie ist die einzige Option, eine unmittelbar lebensbedrohliche Aneurysmaruptur zu verhindern. Der folgende Artikel gibt eine Übersicht über den aktuellen Wissensstand zu Epidemiologie, Pathogenese, Diagnostik und Ultraschall-Screening sowie Therapie des AAA. Zusätzlich werden Behandlungsdaten von 965 AAA-Patienten aus der eigenen Klinik vorgestellt.
Congenital Pulmonary Lymphangiectasia: A Disorder not only of Fetoneonates
Authors: Yuan Shi-Min 
Published: July 2017

AbstractCongenital pulmonary lymphangiectasia (CPL) is a rare developmental disorder of the lung, characterized by dilation of pulmonary subpleural, interlobar, perivascular and peribronchial lymphatics. The incidence of CPL among stillborn and neonates was estimated to be <1%. The etiology of CPL is unknown. However, it has been suspected to be of a genetic background. Recent basic studies revealed that it might be caused by the FOXC2, Vegfr-3 and integrin α9β1gene mutations. A clinical diagnosis of CPL can be made much easier in full-term neonates who present with respiratory distress, pleural (especially chylous) effusions with or without generalized edema. In infancy, the diagnosis seems to be more difficult due to the nonspecific respiratory symptoms like persistent tachypnea, cough and wheeze. Lung biopsy with subsequent histological and immunohistochemical studies is the golden diagnostic method of CPL. Immunohistochemical staining for endothelial cell markers CD31, CD34 and D2-40 confirms lymphatic origin. Therapeutic strategies include supportive, nutritional, investigational, aggressively interventional and surgical regimens, most of which have shown promising outcomes. Although CPL was once regarded as a disorder of very poor prognosis in neonatal onset cases, teenager and adult patients have shown good outcomes upon long-term follow-up.
Can the Rate of C-sections Performed in a Level I Perinatal Center Be Reduced? – An Analysis of the University Gynecology Clinic Rostock, 2008 – 2014
Authors: Genuttis Nele , Bolz Michael , Briese Volker 
Published: July 2017

Abstract
Introduction In Germany the rate of deliveries by cesarean section is continually increasing. Many different reasons have been put forward to explain this trend. The aim of this study was to examine how the C-section rate developed at the University Gynecology Clinic Rostock, one of the biggest maternity hospitals and level I perinatal centers in Germany, based on various maternal and neonatal parameters. The aim was also to identify potential risk factors for C-sections.
Material and Method Various obstetric parameters were obtained from the birth cohort (2008 to 2014; n = 20 091) of the University Gynecology Clinic Rostock. The data was used to calculate parameter-specific C-section rates. Potential risk factors for C-section were identified by regression analysis.
Results The C-section rate dropped from 26.24% to 23.57%. The rate of repeat C-sections also declined. The mean age of the pregnant women increased. Nevertheless, the frequency of cesarean sections in pregnant women aged more than 35 years declined. Rates of being overweight or obese preconception increased. C-section rates increased as BMI values preconception increased. There was a perceptible trend towards attempting the vaginal delivery of children in breech presentation and of twins. The frequency of depressed neonates after vaginal delivery and after C-section decreased. Rates for mild and advanced acidosis increased after both C-sections and vaginal deliveries. Previous C-section, older maternal age, overweight and obesity prior to conception, breech presentation and multiple pregnancies all increased the risk of cesarean sections.
Conclusion This study showed that reducing the rates of C-sections without a deterioration in neonatal outcomes can be achieved even in a large maternity hospital that cares for many high-risk pregnancies.
Nichts wird besser durch Angst
Authors: Casagrande C 
Published: July 2017

Summary„Ich habe die Diagnose bekommen!“ Wenn Patienten mit diesem oder einem ähnlichen Satz das Gespräch beginnen, zucke ich auch heute noch ein wenig zusammen. Denn oft berichten sie dann, dass ein bösartiges Tumorgeschehen in ihrem Körper nachgewiesen wurde. DHZ-Kolumne von HP Christina Casagrande.
Kardiovaskuläre Risikofaktoren bei Diabetes
Authors: Müller-Wieland Dirk 
Published: July 2017

ZUSAMMENFASSUNGDiabetes mellitus ist mit einem deutlich erhöhten kardiovaskulären Risiko verbunden. Daher sollten allgemein Lebensstilmaßnahmen empfohlen und Maßnahmen zur sogenannten Verhältnisprävention politisch umgesetzt werden. Patienten mit Diabetes müssen frühzeitig, effektiv und sicher behandelt werden. Dies betrifft nicht nur die Blutzucker-Senkung, sondern insbesondere auch die Reduktion des arteriellen Blutdruckes und die drastische Senkung des LDL-Cholesterins im Blut. Durch eine frühzeitige effektive und multimodale Therapie kann das kardiovaskuläre Risiko von Patienten mit Diabetes etwa halbiert und langfristig die Gesamtsterblichkeit gesenkt werden.
Acetylated Furostene Glycosides from Solanum gilo Fruits
Authors: Tchoupang Edwige , Reder Christina , Ateba Sylvin , Zehl Martin , Kählig Hanspeter , Njamen Dieudonné , Höller Franziska , Glasl-Tazreiter Sabine , Krenn Liselotte 
Published: July 2017

AbstractIn continuation of our work on a traditional mixture of spices called “Nkui”, used in Cameroon for its influence on womenʼs reproductive health, we investigated the chemical composition of Solanum gilo, one component of “Nkui”. A methanolic extract was studied in detail. After dereplication of several known compounds, two furo-5-stene-derived saponin glycosides with acetylated sugar moieties were isolated. By extensive 1- and 2D NMR experiments and HR-MS and GC-MS methods, the structures were elucidated as 26-[(3‴,4‴,6‴-tri-O-acetyl)-β-D-glucopyranosyloxy]-22-hydroxyfurost-5-en-3β-yl-O-α-L-rhamnopyranosyl-(1″→2′)-β-D-glucopyranoside (A) and 26-[(3‴,4‴,6‴-tri-O-acetyl)-β-D-glucopyranosyloxy]-22-hydroxyfurost-5-en-3β-yl-[O-α-L-rhamnopyranosyl-(1′′′′→4′)-O-α-L-rhamnopyranosyl-(1″→2′)]-β-D-glucopyranoside (B), both new natural compounds.
Diverse continuum of CD4+T-cell states is determined by hierarchical additive integration of cytokine signals
Authors: Eizenberg-Magar Inbal , Rimer Jacob , Zaretsky Irina , Lara-Astiaso David , Reich-Zeliger Shlomit , Friedman Nir 
Published: July 2017

SignificanceUnderstanding the logic by which cells respond to complex signal combinations is challenging. We used CD4+T cells as a model system to study signal integration by systematically mapping their differentiation in response to a large number of cytokine combinations. We find that, in response to varied cytokine mixtures, cells coexpress lineage-specifying proteins at diverse levels, such that the cell population spans a continuum of intermediate states between canonical cell phenotypes. Mathematical modeling explains these results using hierarchical summation of cytokine inputs and correctly predicts population response to new input conditions. These findings suggest that complex cellular responses can be effectively described using relatively simple hierarchical summation rules, providing a framework for prediction of cellular responses to signal combinations.
Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice
Authors: Tejada Miguel A. , Montilla-García Angeles , Cronin Shane J. , Cikes Domagoj , Sánchez-Fernández Cristina , González-Cano Rafael , Ruiz-Cantero M. Carmen , Penninger Josef M. , Vela José M. , Baeyens José M. , Cobos Enrique J. 
Published: July 2017

Significance
New pain medications with novel mechanisms of action are needed. Here we show that sigma-1 antagonism decreases inflammatory pain hypersensitivity by enhancing the actions of endogenous opioid peptides produced by leukocytes in mice. Sigma-1 antagonism results in opioid analgesia only at the inflamed site, where immune cells naturally accumulate. This mechanism, which maximizes the analgesic potential of immune cells in painful inflamed sites, differs from that of conventional analgesics.
Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule
Authors: Ahmad Md. Faiz , Alam Intekhab , Huff Sarah E. , Pink John , Flanagan Sheryl A. , Shewach Donna , Misko Tessianna A. , Oleinick Nancy L. , Harte William E. , Viswanathan Rajesh , Harris Michael E. , Dealwis Chris Godfrey 
Published: July 2017

Significance
The search for anticancer drugs continues to be greatly pursued. The nucleoside analog gemcitabine, which targets ribonucleotide reductase (RR) as a diphosphate and DNA polymerases as a triphosphate, is the standard first-line treatment in patients with pancreatic cancer. However, its cytotoxicity to normal dividing tissues leads to unwanted side effects. Here, we have discovered a nonnucleoside RR inhibitor, naphthyl salicylic acyl hydrazone (NSAH), that has efficacy similar to gemcitabine and the potential to be modified to provide safer and more effective cancer therapies.
Distinct requirements for energy metabolism in mouse primordial germ cells and their reprogramming to embryonic germ cells
Authors: Hayashi Yohei , Otsuka Kei , Ebina Masayuki , Igarashi Kaori , Takehara Asuka , Matsumoto Mitsuyo , Kanai Akio , Igarashi Kazuhiko , Soga Tomoyoshi , Matsui Yasuhisa 
Published: July 2017

Significance
Primordial germ cells (PGCs) are the origin of germ cells and are critically important for continuity of multicellular organisms. Although the unique characteristics of mouse PGCs have been described in gene expression and epigenome levels, the metabolomic and proteomic profiles of PGCs and their significance for PGC properties have been unclear. Our findings in this study demonstrate not only distinct energy metabolisms in PGCs and pluripotent stem cells (PSCs), but also the essential contribution of enhanced oxidative phosphorylation and glycolysis in PGC specification from PSCs, and in reprogramming of PGCs into PSCs, respectively. The results uncover the importance of a shift in main energy metabolism for establishment and maintenance of PGC characteristics.
Maternal photoperiod programs hypothalamic thyroid status via the fetal pituitary gland
Authors: Sáenz de Miera Cristina , Bothorel Béatrice , Jaeger Catherine , Simonneaux Valérie , Hazlerigg David 
Published: July 2017

Significance
In mammals, long-term programming of offspring physiology occurring before birth has effects persisting into adulthood. Appropriate programming allows environmental preadaptation, while inappropriate programming has deleterious health and fitness consequences. To define the mechanistic pathways underlying maternal programming, this study focused on the programming of calendar time before birth, which sets subsequent trajectories for growth and reproduction. This phenomenon depends on day-length perception, encoded via the light-sensitive hormone melatonin from the mother. This study defines the pathway by which maternal melatonin engages with the fetal brain and shows how this prenatal signal leads to a long-term effect on brain thyroid hormone signaling, establishing a new paradigm for investigating epigenetic programming of brain function in utero.
Virus found in a boreal lake links ssDNA and dsDNA viruses
Authors: Laanto Elina , Mäntynen Sari , De Colibus Luigi , Marjakangas Jenni , Gillum Ashley , Stuart David I. , Ravantti Janne J. , Huiskonen Juha T. , Sundberg Lotta-Riina 
Published: July 2017

Significance
We describe the phage FLiP, an ssDNA virus with an icosahedral capsid and an internal lipid membrane. The FLiP genome shows limited similarity to known sequences, although an ssDNA replication mechanism was implied by genome analysis. However, because the capsid protein fold indicates relatedness with the dsDNA viruses of the PRD1–adenovirus lineage, FLiP exhibits a unique combination of structural and replication modules. It is suggested that the capsid protein structure could be used to complement the sequence data when classifying viruses and in detecting their deep evolutionary relationships, especially in the absence of sequence similarities. Furthermore, these findings demonstrate the value of characterizing unknown viruses from diverse environmental sources to understand the diversity of the microbial world.
Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells
Authors: Li Yun , Fu Jianxin , Ling Yun , Yago Tadayuki , McDaniel J. Michael , Song Jianhua , Bai Xia , Kondo Yuji , Qin Yannan , Hoover Christopher , McGee Samuel , Shao Bojing , Liu Zhenghui , Sonon Roberto , Azadi Parastoo , Marth Jamey D. , McEver Rodger P. , Ruan Changgeng , Xia Lijun 
Published: July 2017

Significance
Although many platelet glycoproteins, such as GPIbα and GPIIb/IIIa, are predominately modified by O-glycans, the biological importance of O-glycans in platelet homeostasis is unclear. Here, we report that platelets lacking O-glycans exhibit a reduced life-span and increased clearance in the liver due to defective sialylation. We found that Kupffer cells play a major role in clearing desialylated O-glycan–deficient platelets in cooperation with hepatocytes via the hepatic asialoglycoprotein receptor. These findings reveal how O-glycosylation regulates platelet homeostasis and clearance; they may also provide insights into the pathogenesis of disorders with thrombocytopenia such as sepsis and immune thrombocytopenia refractory to splenectomy.
On, Se and related valency alternations in Medieval French
Authors: Wolfsgruber Anne C. 
Published: July 2017

Abstract
This article explores the question of why Medieval French does not use se-constructions as exhaustively as other Medieval Romance varieties and why the indefinite pronoun on is clearly the preferred choice. It is claimed that se exhibits affix-like behavior in passive constructions and that it is very likely to be a morphological exponent of absorbing the [+Def] feature on T in IACs. These assumptions are connected to the possibility within a language system to store affixes as independent lexical entries, following Speas, 1995. It will be shown that Medieval French seems to be a language system in flux in which signs of NSL > non-NSL were present over a longer period of time. The uncertain status of affixes within these radical changes would have prompted learners to go for a multifunctional solution that is readily available and unequivocally identifiable: on.
Transitivity and valency in Northern Akhvakh
Authors: Creissels Denis 
Published: July 2017

Abstract
This paper analyzes transitivity and valency in Northern Akhvakh, a language belonging to the Andic group of languages included in the Northeast Caucasian (or Nakh-Daghestanian) family. Northern Akhvakh clause structure is characterized by an extreme flexibility of constituent order, omissibility of arguments with an either anaphoric or unspecified reading, and fully consistent ergative coding of core NPs. Northern Akhvakh has a very low rate of transitivity prominence, and an extremely strong tendency to derive the causal member of noncausal / causal pairs from its noncausal counterpart. Ambitransitivity is very marginal, and the productivity of morphologically unmarked valency alternations is very limited. Causative derivation is the only valency changing mechanism involving verb morphology, and ingestion verbs are the only transitive verbs for which causative derivation is productive.
Risk Screen of Freshwater Tropical Ornamental Fishes for the Conterminous United States
Authors: Hill Jeffrey E. , Tuckett Quenton M. , Hardin Scott , Lawson Larry L. , Lawson Katelyn M. , Ritch Jared L. , Partridge Lauren 
Published: July 2017

AbstractThe trade in ornamental fish is increasingly viewed as a major source for the introduction of invasive species into the environment. However, few ornamental fishes are established and widespread in the conterminous United States, and fewer still are thought to cause noticeable environmental impacts. To better evaluate the risk of this pathway, we conducted a risk screen of 34 important freshwater ornamental fish species by using the Fish Invasiveness Screening Kit (FISK) version 2 for the conterminous United States. Screens from three to five independent assessors resulted in categorization of 91–100% of the species as noninvasive. The low climate match of these mostly tropical species largely confines establishment risk to subtropical regions, primarily peninsular Florida, and to isolated thermal refuges (e.g., geothermal springs) in otherwise unsuitable climates. Few data on impacts exist for tropical ornamental fish in the conterminous United States, and there is little evidence for the occurrence of large, long‐term effects despite local impacts for a few species. Our results indicate that the freshwater tropical ornamental fish trade is less risky to the conterminous United States than has been concluded in most previous studies. Further risk assessment for management decisions might be required on a regional scale or for localized, high‐risk situations.Received November 3, 2016; accepted March 23, 2017 Published online July 18, 2017
Sensory Biology as a Risk Factor for Invasion Success and Native Fish Decline
Authors: Abrahams M. V. , Bassett D. K. , Montgomery J. C. 
Published: July 2017

AbstractNative freshwater fish populations are among the world's most threatened taxa due to the combined effects of habitat degradation and invasive alien species. Habitat degradation negatively impacts native species, whereas invasive species tend to possess adaptations, such as thermal and salinity tolerance, that are more suited to the degraded environment. Sensory ecology may also be a contributing factor. Most threatened native species are visual feeders, whereas invasive species found in degraded systems often have nonvisual specializations. Behavioral and distributional characteristics of the invasive Western Mosquitofish Gambusia affinis and the New Zealand native Inanga Galaxias maculatus illustrate the potential for sensory biology to influence foraging success, distribution, and species interaction between degraded and clear habitats. Behavioral trials measured the change in feeding rate in clear (0 NTU) and turbid (100 NTU) water over 30 min for Inanga and Western Mosquitofish feeding on brine shrimp Artemia salina nauplii. These experiments showed that Western Mosquitofish maintained similar feeding rates between clear and turbid water, whereas the native species exhibited a marked decline in feeding efficiency in turbid water. Across a strong natural turbidity boundary, the alien species was found to dominate turbid habitat less than 1 m from clear water, where both species were found. Accounting for sensory biology as a potential contributing factor in the establishment of invasive fish species in degraded habitat may help to identify invasive species risk and to shape strategies for rehabilitating native species.
Comparison of Day and Night Electrofishing to Sample Smallmouth Bass in Natural Lakes of Eastern South Dakota
Authors: Blackwell Brian G. , Kaufman Todd M. , Moos Tyrel S. , Ermer Mark J. 
Published: July 2017

Abstract
Smallmouth Bass Micropterus dolomieu, an important sport fish and apex predator, are commonly sampled by fisheries personnel using night electrofishing. We assessed day and night electrofishing catch per hour of effort (CPUE), sampling precision (i.e., CV), and size structure of Smallmouth Bass in eight northeast South Dakota natural lakes during 2013–2016 to determine if day electrofishing was a viable option for population assessment. Night CPUE was generally greater than day CPUE in paired samples. Significant differences in CPUE for fish ≥ 180-mm TL were identified in approximately one-third of lake year comparisons. Day and night CPUE were more likely to be significantly different in fish &lt; 350 mm-TL. A significant linear relationship was identified between day CPUE and night CPUE for all fish. Coefficients of variation of CPUE were similar between day and night samples. Significant differences in proportional size distribution (PSD) were identified for 6 of 15 day–night pairs, but no pattern was identified and no differences in proportional size distribution of preferred-length fish (PSD-P) values were found. A linear relationship was identified between day and night PSD and day and night PSD-P, and neither relationship differed from the 1:1 line. A significant curvilinear relationship was present between the percent deviations (PD) of day and night CPUE across Secchi depths. We believe that day electrofishing can be used to assess Smallmouth Bass populations in eastern South Dakota natural lakes.
Received January 9, 2017; accepted July 3, 2017 Published online October 11, 2017
A Modeling Framework to Quantify the Influence of Hydrology on the Abundance of a Migratory Indian Shad, the Hilsa Tenualosa ilisha
Authors: Naskar Malay , Chandra Ganesh , Sahu S. K. , Raman R. K. 
Published: July 2017

Abstract
It is envisaged that the influence of river hydrology on the commercial catch of anadromous species in river–estuary systems is very pronounced. We delineate a general framework to quantify the effect of changing river hydrology on the catch of a very unique anadromous species, the Hilsa Tenualosa ilisha, a shad species that is distributed across the Indo-Pacific region. The Narmada River–estuary system was studied as a representative for the region. Two synthesized factors—migratory habitat availability (factor 1) and migratory habitat quality potential (factor 2)—were derived from five hydrological variables to explain 96% of the variability in the hydrological regime of the Narmada River–estuary system. Based on the proposed autoregressive integrated moving average with explanatory variables (ARIMAX) modeling framework, we found that both factors had significant positive effects. Model-based forecasts of Hilsa catch revealed a decreasing trend in the future if a similar hydrological regime prevails. In a simulated future scenario, a 15% increase in Hilsa catch was predicted to occur in response to a 2% increase in factor 1, considering the last 5 years’ average catch as a benchmark. Some management strategies focused on controlling the hydrological regime are suggested to enhance Hilsa fisheries.
Received February 15, 2017; accepted July 1, 2017 Published online October 11, 2017
Retracted: Effective Dose of Salmon GnRHa for Induction of Ovulation in Channel Catfish
Authors: Chatakondi Nagaraj G 
Published: July 2017

Abstract
The present study was conducted to determine the minimum effective dose of salmon gonadotropin-releasing hormone analog (sGnRHa) to stimulate ovulation in Channel Catfish Ictalurus punctatus. Four doses of sGnRHa—0, 10, 15, and 25 µg/kg body weight (BW)—were compared with the commonly used dose of 100 µg/kg BW of mammalian luteinizing hormone releasing hormone analog (mLHRHa) to induce spawning in Channel Catfish. Hormone-induced catfish yielded significantly higher levels of plasma estradiol and ovulation success than saline-injected control fish. Ovulation ratio, relative fecundity, and number of fry per kilogram with 10 µg sGnRHa/kg were lower than those treated with 15 and 25 µg. To further refine the sGnRHa dose, spawning trials with 3- and 4-year-old Channel Catfish were compared using doses of either 10, 15, or 20 µg sGnRHa/kg BW. The relative fecundity (8,322 eggs/kg BW) and fry production (2,533 fry/kg BW) were higher in fish from the 15-µg sGnRHa/kg BW treatment. Hence, the results of this study suggest that 15 µg sGnRHa/kg BW is the minimum effective dose comparable with widely used mLHRHa to induce spawning in Channel Catfish and produce hybrid (Channel Catfish × Blue Catfish I. furcatus) embryos in hatcheries.