bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Regulation of Zfp30 Expression in Murine Airway Epithelia Through Altered Binding of ZFP148 to rs51434084
Authors: Laudermilk Lucas T , Thomas Joseph M , Kelada Samir N 
Published: December 2017

Abstract
Neutrophil chemotaxis to the airways is a key aspect of host response to microbes and a feature of multiple pulmonary diseases including asthma. Tight regulation of this recruitment is critical to prevent unwanted host tissue damage and inflammation. Using a mouse (Mus musculus) model of asthma applied to the Collaborative Cross population, we previously identified a lung gene expression quantitative trait locus (eQTL) for Zinc finger protein 30 (Zfp30) that was also a QTL for neutrophil recruitment and the hallmark neutrophil chemokine CXCL1. The Zfp30 eQTL is defined by three functionally distinct haplotypes. In this study, we searched for causal genetic variants that underlie the Zfp30 eQTL to gain a better understanding of this candidate repressor’s regulation. First, we identified a putative regulatory region spanning 500 bp upstream of Zfp30, which contains 10 SNPs that form five haplotypes. In reporter gene assays in vitro, these haplotypes recapitulated the three previously identified in vivo expression patterns. Second, using site-directed mutagenesis followed by reporter gene assays, we identified a single variant, rs51434084, which explained the majority of variation in expression between two out of three haplotype groups. Finally, using a combination of in silico predictions and electrophoretic mobility shift assays, we identified ZFP148 as a transcription factor that differentially binds to the Zfp30 promoter region harboring rs51434084. In conclusion, we provide evidence in support of rs51434084 being a causal variant for the Zfp30 eQTL, and have identified a mechanism by which this variant alters Zfp30 expression, namely differential binding of ZFP148.
Retratos não-modelares da modernidade: hegemonia e contra-hegemonia no pensamento brasileiro
Authors: Tavolaro Sergio Barreira de Faria 
Published: December 2017

O presente artigo almeja apurar no seio do pensamento social brasileiro a existência de elementos que indiquem alternativas a noções sociológicas consolidadas acerca da modernidade. Indaga-se sobre as premissas que subjazem imagens do Brasil talhadas em algumas obras ditas “clássicas” de interpretação de nossa formação social. Em seguida, busca-se identificar peças-chave do quadro de referência que, desde longa data, circunscreve os horizontes de ideação sociológica acerca da experiência moderna. Logo após, são contempladas as reflexões de analistas contemporâneos a respeito do valor heurístico de retratos do país delineados no seio do pensamento brasileiro. Por fim, à luz de programas e abordagens da teoria social contemporânea, lança-se mão de insights e sugestões ensaiadas em tais interpretações “clássicas” com o propósito de indicar saídas a alguns dos impasses e limites da sociologia da modernidade sublinhados na atualidade.
Insights sociológicos: sujeito e subjetivação em Walter Benjamin e Hannah Arendt
Authors: Aquino Luseni 
Published: December 2017

O texto apresenta uma breve discussão acerca dos insights que as obras de Hannah Arendt e Walter Benjamim oferecem para a tematização do sujeito e dos processos de subjetivação que tem sido marcante nas investigações sociológicas. Orienta a argumentação a hipótese de que, em ambos os casos, as reflexões são pautadas por uma compreensão bastante específica da vida social e do desenrolar histórico, que tem como fulcro o caráter contingente do agir humano. Neste sentido, identificam-se nas categorias “ação” e “experiência” o cerne das proposições dos autores. Conclui-se, ao final, que embora Arendt e Benjamin tenham apontado os imensos desafios que as condições materiais e a mentalidade moderna impõem ao sujeito como possibilidade para o existir humano, ambos indicam que o sujeito livre, como postulado que preserva o homem de ser reduzido a objeto ou recurso de poder ou prazer, subsiste não apenas como valor, mas também como potencialidade.
Formação e profissão de jovens e pedagogos na Amazônia
Authors: Maia Garcia Fabiane , Barbosa Nogueira Jocélia , Dias Moya Maria Angélica 
Published: December 2017

O trabalho corresponde a um entrelace entre duas pesquisas desenvolvidas no Programa de Pós-Graduação em Educação da Universidade Federal do Amazonas. A primeira, no doutoramento e em fase de conclusão discute a profissão como um processo de formação no percurso do pedagogo e a segunda, em fase inicial, se preocupa com o proceso de como ocorre a orientação dos estudantes do Ensino Médio, no ambiente escolar quando vinculado a escolha da formação profissional em um curso universitário num contexto que envolve demandas de cunho pessoal, familiar e de mercado de trabalho da região Amazônica.
Corpo e alteridade como expressão e produção cultural: Um olhar empírico
Authors: Cunha António Camilo 
Published: December 2017

A cultura e o corpo estão ligados, tendo um carater dinâmico de Ser e de se Compreender. Desenvolvem-se e complementam-se entre si, permanentemente, tendo sempre na sua dinâmica relacional um suporte de carater histórico e até filosófico. Se para Descartes (1596-1650), o corpo era um instrumento (res-extensa) do cogito (res- cogito), na atualidade o corpo e cogito fazem o “eu”. Um “eu” à maneira de Espinosa (1632-1677), isto é, um “eu” monista, onde corpo, alma, espírito – são uma totalidade. Um corpo que na sua totalidade emerge como expressão e produção cultural, não esquecendo a relação com outros “eus”..
Validation of the visual analog scale in the cervical spine
Authors: MacDowall Anna , Skeppholm Martin , Robinson Yohan , Olerud Claes 
Published: December 2017

OBJECTIVEThe visual analog scale (VAS) is frequently used to measure treatment outcome in patients with cervical spine disorders. The minimum clinically important difference (MCID) is the smallest change in a score that has clinical importance to the patient. Although it has been established for other medical fields, knowledge of the VAS MCID for the cervical spine is sparse, and it has rarely been considered in relation to measurement noise. The goals in this study were as follows: 1) to validate the VAS-neck and VAS-arm instruments for the cervical spine (e.g., repeatability); 2) to investigate the possible influence of predictive factors and the Hospital Anxiety and Depression Scale (HADS) score on repeatability; and 3) to compute the MCID with 5 different methods.METHODSA post hoc analysis of a prospective randomized controlled trial with 151 patients undergoing surgery for cervical radiculopathy due to degenerative disc disease was performed. Information on age, sex, smoking habits, exercise, employment status, HADS score, and VAS-neck and VAS-arm scores was gathered before surgery and after 1 year. The VAS was applied twice on every occasion, with 15 minutes in between. Repeatability and the association with predictors and HADS score were analyzed using the 1-sample t-test, linear regression models, and Spearman correlation. The MCID was calculated with the following methods: average change, change difference, receiver operating characteristic curve, effect size, and minimum detectable change (MDC).RESULTSThe repeatability in VAS-neck was 8.1 mm, and in VAS-arm it was 10.4 mm. Less consistent values on the VAS correlated to female sex and higher values on the HADS. For VAS-neck the MCID ranged from 4.6 to 21.4, and for VAS-arm it ranged from 1.1 to 29.1. The highest MCID came from the MDC method, which was the only method that gave values above the measurement noise in both VAS-neck and VAS-arm.CONCLUSIONSMeasurement noise in VAS-neck and VAS-arm for the cervical spine was influenced by female sex and HADS score. The only method to compute MCID that consistently gave results above the measurement noise in VAS-neck and VAS-arm was the MDC.Clinical trial registration no.: 44347115 (www.isrctn.com).
Evolution of the process underlying floral zygomorphy development in pentapetalous angiosperms
Authors: Bukhari Ghadeer , Zhang Jingbo , Stevens Peter F. , Zhang Wenheng 
Published: December 2017

PREMISE OF THE STUDY:Observations of floral ontogeny indicated that floral organ initiation in pentapetalous flowers most commonly results in a median‐abaxial (MAB) petal during early development, a median‐adaxial (MAD) petal being less common. Such different patterns of floral organ initiation might be linked with different morphologies of floral zygomorphy that have evolved in Asteridae. Here, we provide the first study of zygomorphy in pentapetalous angiosperms placed in a phylogenetic framework, the goal being to find if the different patterns of floral organ initiation are connected with particular patterns of zygomorphy.METHODS:We analyzed patterns of floral organ initiation and displays of zygomorphy, extracted from floral diagrams representing 405 taxa in 330 genera, covering 83% of orders (30 out of 36) and 37% of families (116 out of 313) in core eudicots in the context of a phylogeny using ancestral state reconstructions.KEY RESULTS:The MAB petal initiation is the ancestral state of the pattern of floral organ initiation in pentapetalous angiosperms. Taxa with MAD petal initiation represent ∼30 independent origins from the ancestral MAB initiation. There are distinct developmental processes that give rise to zygomorphy in different lineages of pentapetalous angiosperms, closely related lineages being likely to share similar developmental processes.CONCLUSIONS:We have demonstrated that development indeed constrains the processes that give rise to floral zygomorphy, while phylogenetic distance allows relaxation of these constraints, which provides novel insights on the role that development plays in the evolution of floral zygomorphy.
Genetic, morphological, and spectral characterization of relictual Niobrara River hybrid aspens (Populus × smithii)
Authors: Deacon Nicholas John , Grossman Jake Joseph , Schweiger Anna Katharina , Armour Isabella , Cavender‐Bares Jeannine 
Published: December 2017

PREMISE OF THE STUDY:Aspen groves along the Niobrara River in Nebraska have long been a biogeographic curiosity due to morphological differences from nearby remnant Populus tremuloides populations. Pleistocene hybridization between P. tremuloides and P. grandidentata has been proposed, but the nearest P. grandidentata populations are currently several hundred kilometers east. We tested the hybrid‐origin hypothesis using genetic data and characterized putative hybrids phenotypically.METHODS:We compared nuclear microsatellite loci and chloroplast sequences of Niobrara River aspens to their putative parental species. Parental species and putative hybrids were also grown in a common garden for phenotypic comparison. On the common garden plants, we measured leaf morphological traits and leaf‐level spectral reflectance profiles, from which chemical traits were derived.KEY RESULTS:The genetic composition of the three unique Niobrara aspen genotypes is consistent with the hybridization hypothesis and with maternal chloroplast inheritance from P. grandidentata. Leaf margin dentition and abaxial pubescence differentiated taxa, with the hybrids showing intermediate values. Spectral profiles allowed statistical separation of taxa in short‐wave infrared wavelengths, with hybrids showing intermediate values, indicating that traits associated with internal structure of leaves and water absorption may vary among taxa. However, reflectance values in the visible region did not differentiate taxa, indicating that traits related to pigments are not differentiated.CONCLUSIONS:Both genetic and phenotypic results support the hypothesis of a hybrid origin for these genetically unique aspens. However, low genetic diversity and ongoing ecological and climatic threats to the hybrid taxon present a challenge for conservation of these relictual boreal communities.
Multiple fixed point theorems for contractive and Meir-Keeler type mappings defined on partially ordered spaces with a distance
Authors: Choban Mitrofan M , Berinde Vasile 
Published: December 2017

<p>We introduce and study a general concept of multiple fixed point for mappings defined on partially ordered distance spaces in the presence of a contraction type condition and appropriate monotonicity properties. This notion and the obtained results complement the corresponding ones from [M. Choban, V. Berinde, A general concept of multiple fixed point for mappings defined on spaces with a distance, Carpathian J. Math. 33 (2017), no. 3, 275--286] and also simplifies some concepts of multiple fixed point considered by various authors in the last decade or so.</p>
Satellite drag effects due to uplifted oxygen neutrals during super magnetic storms
Authors: Lakhina Gurbax S. , Tsurutani Bruce T. 
Published: December 2017

Abstract. During intense magnetic storms, prompt penetration electric fields (PPEFs) through E  ×  B forces near the magnetic equator uplift the dayside ionosphere. This effect has been called the dayside super-fountain effect. Ion-neutral drag forces between the upward moving O+ (oxygen ions) and oxygen neutrals will elevate the oxygen atoms to higher altitudes. This paper gives a linear calculation indicating how serious the effect may be during an 1859-type (Carrington) superstorm. It is concluded that the oxygen neutral densities produced at low-Earth-orbiting (LEO) satellite altitudes may be sufficiently high to present severe satellite drag. It is estimated that with a prompt penetrating electric field of ∼ 20 mV m−1 turned on for 20 min, the O atoms and O+ ions are uplifted to 850 km where they produce about 40-times-greater satellite drag per unit mass than normal. Stronger electric fields will presumably lead to greater uplifted mass.
Controlling Spatiotemporal Mechanics of Supramolecular Hydrogel Networks with Highly Branched Cucurbit[8]uril Polyrotaxanes
Authors: Tan Cindy Soo Yun , Liu Ji , Groombridge Alexander S. , Barrow Steven J. , Dreiss Cécile A. , Scherman Oren A. 
Published: December 2017

AbstractAttempts to rationally tune the macroscopic mechanical performance of supramolecular hydrogel networks through noncovalent molecular interactions have led to a wide variety of supramolecular materials with desirable functions. While the viscoelastic properties are dominated by temporal hierarchy (crosslinking kinetics), direct mechanistic studies on spatiotemporal control of supramolecular hydrogel networks, based on host–guest chemistry, have not yet been established. Here, supramolecular hydrogel networks assembled from highly branched cucurbit[8]uril‐threaded polyrotaxanes (HBP‐CB[8]) and naphthyl‐functionalized hydroxyethyl cellulose (HECNp) are reported, exploiting the CB[8] host–guest complexation. Mechanically locking CB[8] host molecules onto a highly branched hydrophilic polymer backbone, through selective binary complexation with viologen derivatives, dramatically increases the solubility of CB[8]. Additionally, the branched architecture enables tuning of material dynamics of the supramolecular hydrogel networks via both topological (spatial hierarchy) and kinetic (temporal hierarchy) control. Relationship between macroscopic properties (time‐ and temperature‐dependent rheological properties, thermal stability, and reversibility), spatiotemporal hierarchy, and chain dynamics of the highly branched polyrotaxane hydrogel networks is investigated in detail. Such kind of tuning of material mechanics through spatiotemporal hierarchy improves our understanding of the challenging relationship between design of supramolecular polymeric materials and their complex viscoelasticity, and also highlights a facile strategy to engineer dynamic supramolecular materials.
A Rapid Photopatterning Method for Selective Plating of 2D and 3D Microcircuitry on Polyetherimide
Authors: Marques‐Hueso Jose , Jones Thomas D. A. , Watson David E. , Ryspayeva Assel , Esfahani Mohammadreza Nekouie , Shuttleworth Matthew P. , Harris Russell A. , Kay Robert W. , Desmulliez Marc P. Y. 
Published: December 2017

AbstractIn this work, a method for the rapid synthesis of metallic microtracks on polyetherimide is presented. The method relies on the photosynthesis of silver nanoparticles on the surface of the polymer substrates from photosensitive silver chloride (AgCl), which is synthesized directly on the polyetherimide surface. The study reveals that the use of AgCl as a photosensitive intermediate accelerates the reactions leading to the formation of silver nanoparticles by up to two orders of magnitude faster than other photodecomposition schemes. The patterning can be conducted under blue light, with notable advantages over UV exposure. Polymers of significant interest to the microelectronics and 3D printing industries can be directly patterned by light using this photography‐inspired technique at throughputs high enough to be commercially advantageous. Light exposures as short as a few seconds are sufficient to allow the direct metallization of the illuminated polyetherimide surface. The results show that the silver required for the seed layer is minimal, and the later copper electroless plating results in the selective growth of conductive tracks for circuitry on the light‐patterned areas, both on flexible films and 3D printed surfaces.
Superhydrophobic Shape Memory Polymer Arrays with Switchable Isotropic/Anisotropic Wetting
Authors: Cheng Zhongjun , Zhang Dongjie , Lv Tong , Lai Hua , Zhang Enshuang , Kang Hongjun , Wang Yongzhen , Liu Pengchang , Liu Yuyan , Du Yi , Dou Shixue , Jiang Lei 
Published: December 2017

AbstractSmart surfaces with tunable wettability have aroused much attention in the past few years. However, to obtain a surface that can reversibly transit between the lotus‐leaf‐like superhydrophobic isotropic and rice‐leaf‐like superhydrophobic anisotropic wettings is still a challenge. This paper, by mimicking microstructures on both lotus and rice leaves, reports such a surface that is prepared by creating micro/nanostructured arrays on the shape memory polymer. On the surface, the microstructure shapes can be reversibly changed between the lotus‐leaf‐like random state and the rice‐leaf‐like 1D ordered state. Accordingly, repeated switch between the superhydrophobic isotropic and anisotropic wettings can be displayed. Research results indicate that the smart controllability is ascribed to the excellent shape memory effect of the polymer, which endows the surface with special ability in memorizing different microstructure shapes and wetting properties. Meanwhile, based on the smart wetting performances, the surface is further used as a rewritable functional platform, on which various droplet transportation programmes are designed and demonstrated. This work reports a superhydrophobic surface with switchable isotropic/anisotropic wettings, which not only provides a novel functional material but also opens a new avenue for application in controlled droplet transportation.
NiCo Alloy Nanoparticles Decorated on N‐Doped Carbon Nanofibers as Highly Active and Durable Oxygen Electrocatalyst
Authors: Fu Yue , Yu Hai‐Yang , Jiang Cong , Zhang Tian‐Heng , Zhan Run , Li Xiaowei , Li Jian‐Feng , Tian Jing‐Hua , Yang Ruizhi 
Published: December 2017

AbstractThe exploring of catalysts with high‐efficiency and low‐cost for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is one of the key issues for many renewable energy systems including fuel cells, metal–air batteries, and water splitting. Despite several decades pursuing, bifunctional oxygen catalysts with high catalytic performance at low‐cost, especially the one that could be easily scaled up for mass production are still missing and highly desired. Herein, a hybrid catalyst with NiCo alloy nanoparticles decorated on N‐doped carbon nanofibers is synthesized by a facile electrospinning method and postcalcination treatment. The hybrid catalyst NiCo@N‐C 2 exhibits outstanding ORR and OER catalytic performances, which is even surprisingly superior to the commercial Pt/C and RuO2 catalysts, respectively. The synergetic effects between alloy nanoparticles and the N‐doped carbon fiber are considered as the main contributions for the excellent catalytic activities, which include decreasing the intrinsic and charge transfer resistances, increasing CC, graphitic‐N/pyridinic‐N contents in the hybrid catalyst. This work opens up a new way to fabricate high‐efficient, low‐cost oxygen catalysts with high production.
Tunable Förster Resonance Energy Transfer in Colloidal Nanoparticles Composed of Polycaprolactone‐Tethered Donors and Acceptors: Enhanced Near‐Infrared Emission and Compatibility for In Vitro and In Vivo Bioimaging
Authors: Yang Cangjie , Wang Xiaochen , Huang Shuo , Wang Mingfeng 
Published: December 2017

AbstractA near‐infrared (NIR) fluorescent donor/acceptor (D/A) nanoplatform based on Förster resonance energy transfer is important for applications such as deep‐tissue bioimaging and sensing. However, previously reported D/A nanoparticles (NPs) often show limitations such as aggregation‐induced fluorescence quenching and poor interfacial compatibility that reduces the efficiency of the energy transfer and also leads to leaching of the small molecular fluorophores from the NP matrix. Here highly NIR‐fluorescent D/A NPs with a fluorescence quantum yield as high as 46% in the NIR region (700–850 nm) and robust optical stability are reported. The hydrophobic core of each NP is composed of donor and acceptor moieties both of which are tethered with polycaprolactone (PCL), while the hydrophilic corona is composed of poly[oligo(ethylene glycol) methyl ether methacrylate] to offer colloidal stability and “stealthy” effect in aqueous media. The PCL matrix in each colloidal NP not only offers biocompatibility and biodegradability but also minimizes the aggregation‐caused fluorescence quenching of D/A chromophores and prevents the leakage of the NIR fluorophores from the NPs. In vivo imaging using these NIR NPs in live mice shows contrast‐enhanced imaging capability and efficient tumor‐targeting through enhanced permeability and retention effect.
Ascidian‐Inspired Fast‐Forming Hydrogel System for Versatile Biomedical Applications: Pyrogallol Chemistry for Dual Modes of Crosslinking Mechanism
Authors: Cho Jung Ho , Lee Jung Seung , Shin Jisoo , Jeon Eun Je , An Soohwan , Choi Yi Sun , Cho Seung‐Woo 
Published: December 2017

AbstractExploitation of unique biochemical and biophysical properties of marine organisms has led to the development of functional biomaterials for various biomedical applications. Recently, ascidians have received great attention, owing to their extraordinary properties such as strong underwater adhesion and rapid self‐regeneration. Specific polypeptides containing 3,4,5‐trihydroxyphenylalanine (TOPA) in the blood cells of ascidians are associated with such intrinsic properties generated through complex oxidative processes. In this study, a bioinspired hydrogel platform is developed, demonstrating versatile applicability for tissue engineering and drug delivery, by conjugating pyrogallol (PG) moiety resembling ascidian TOPA to hyaluronic acid (HA). The HA–PG conjugate can be rapidly crosslinked by dual modes of oxidative mechanisms using an oxidant or pH control, resulting in hydrogels with different mechanical and physical characteristics. The versatile utility of HA–PG hydrogels formed via different crosslinking mechanisms is tested for different biomedical platforms, including microparticles for sustained drug delivery and tissue adhesive for noninvasive cell transplantation. With extraordinarily fast and different routes of PG oxidation, ascidian‐inspired HA–PG hydrogel system may provide a promising biomaterial platform for a wide range of biomedical applications.