bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opioid Prescribing for the Treatment of Acute Pain in Children on Hospital Discharge
Authors: Monitto Constance L. , Hsu Aaron , Gao Shuna , Vozzo Paul T. , Park Paul S. , Roter Deborah , Yenokyan Gayane , White Elizabeth D. , Kattail Deepa , Edgeworth Amy E. , Vasquenza Kelly J. , Atwater Sara E. , Shay Joanne E. , George Jessica A. , Vickers Barbara A. , Kost-Byerly Sabine , Lee Benjamin H. , Yaster Myron 
Published: November 2017

BACKGROUND:
The epidemic of nonmedical use of prescription opioids has been fueled by the availability of legitimately prescribed unconsumed opioids. The aim of this study was to better understand the contribution of prescriptions written for pediatric patients to this problem by quantifying how much opioid is dispensed and consumed to manage pain after hospital discharge, and whether leftover opioid is appropriately disposed of. Our secondary aim was to explore the association of patient factors with opioid dispensing, consumption, and medication remaining on completion of therapy.

METHODS:
Using a scripted 10-minute interview, parents of 343 pediatric inpatients (98% postoperative) treated at a university children’s hospital were questioned within 48 hours and 10 to 14 days after discharge to determine amount of opioid prescribed and consumed, duration of treatment, and disposition of unconsumed opioid. Multivariable linear regression was used to examine predictors of opioid prescribing, consumption, and doses remaining.

RESULTS:
Median number of opioid doses dispensed was 43 (interquartile range, 30–85 doses), and median duration of therapy was 4 days (interquartile range, 1–8 days). Children who underwent orthopedic or Nuss surgery consumed 25.42 (95% confidence interval, 19.16–31.68) more doses than those who underwent other types of surgery (P < .001), and number of doses consumed was positively associated with higher discharge pain scores (P = .032). Overall, 58% (95% confidence interval, 54%–63%) of doses dispensed were not consumed, and the strongest predictor of number of doses remaining was doses dispensed (P < .001). Nineteen percent of families were informed how to dispose of leftover opioid, but only 4% (8 of 211) did so.

CONCLUSIONS:
Pediatric providers frequently prescribed more opioid than needed to treat pain. This unconsumed opioid may contribute to the epidemic of nonmedical use of prescription opioids. Our findings underscore the need for further research to develop evidence-based opioid prescribing guidelines for physicians treating acute pain in children.
Alkalinized Lidocaine Preloaded Endotracheal Tube Cuffs Reduce Emergence Cough After Brief Surgery: A Prospective Randomized Trial
Authors: Nath Papu , Williams Stephan , Herrera Méndez Luis Fernando , Massicotte Nathalie , Girard François , Ruel Monique 
Published: November 2017

BACKGROUND:
Alkalinized lidocaine in the endotracheal tube (ETT) cuff decreases the incidence of cough and throat pain on emergence after surgery lasting more than 2 hours. However, alkalinized lidocaine needs 60–120 minutes to cross the ETT cuff membrane; therefore, its usefulness in shorter duration surgery is unknown. This prospective double-blind randomized controlled trial tested the hypothesis that alkalinized lidocaine would reduce the incidence of emergence cough after surgeries lasting <120 minutes.

METHODS:
After local ethics board approval, American Society of Anesthesiologists I–III patients consented to be randomized into 1 of 2 groups receiving either alkalinized lidocaine (group AL) or saline (group S) to inflate the ETT cuff. Cuffs were prefilled >90 minutes before intubation with either 2 mL of 2% lidocaine and 8 mL of 8.4% bicarbonate (group AL) or 10 mL of normal saline (group S). Cuffs were emptied immediately before intubation. After intubation, either 2 mL of 2% lidocaine (AL) or 2 mL of saline (S) were injected into the cuff. Additional 8.4% bicarbonate (AL) or saline (S) was injected into the cuff until there was no air leak. Anesthesia was maintained using desflurane, rocuronium, and either fentanyl or sufentanil to maintain vital signs within 20% of baseline values. Opioids administered in prophylaxis of extubation cough were proscribed. A standardized “no touch” emergence technique was used. A blinded assessor noted any cough above 0.2 minimum alveolar concentration (MAC) of expired desflurane. At 0.2 MAC, once every 30 seconds, the patient was instructed to open his eyes and extubation occurred once a directed response was noted.

RESULTS:
A total of 213 patients were randomized and 100 patients in each group completed the experimental protocol. The incidence of extubation cough in group AL was 12%, significantly lower (1-sided P = .045) than the 22% incidence in group S. The 1-tailed risk ratio for cough in group AL was 0.55 (0–0.94, P = .045). Total amount of opioids administered (P = .194), ETT cuff preloading times (P = .259), and extubation times (P = .331) were not significantly different between groups. The average duration of surgery was 59 ± 28 minutes in group AL and 52 ± 29 minutes in group S (P = .057).

CONCLUSIONS:
Alkalinized lidocaine in the ETT cuff significantly decreased general anesthesia emergence cough after surgeries with an average duration of slightly <1 hour.
Diverse parenting goals and community music in early childhood
Authors: Young Susan 
Published: November 2017

Abstract
My aim in this article is to look at how one aspect of English policy converts into practice in a community music project designed for under-3-year-olds with their mothers. The study that informs the discussion in this article takes a case study approach, focusing on one musician and the once-weekly music sessions that he provided for a group of Somali-born mothers and their children. The article explores how neoliberal policies have resulted in early childhood music work in the community framed by an interventionist agenda; however, in the case that is the focus of this article, we will see how the use of music as parenting intervention failed. I suggest why this might be so, explaining how diverse parenting goals result in varying parenting practices. Finally, I suggest a return to a ‘critical’ community music aligned more with the original aims of the community music movement in the United Kingdom.
Through a baby’s ears: Musical interactions in a family community
Authors: Costa-Giomi Eugenia , Benetti Lucia 
Published: November 2017

Abstract
We studied how the members of a family with three young children made and shared music with each other and the ways in which musical interactions supported their sense of community. We collected data by recording the soundscape of the family from the vantage point of 15-month-old Travis continuously for almost twelve hours per day for two days. We identified the following four musical behaviours corresponding to Wood and Judikis’ four elements of community: (1) Common purpose and mutual responsibility; (2) Acknowledgement of connectedness; (3) Respect for individual differences; (4) Commitment to the well-being of the members and the integrity of the group. The results of this case study based on behavioural data gathered in the family home show the effectiveness of music in fostering communication, expressing emotional connectedness, and enriching the daily life of parents and children.
Creating ties of intimacy through music: The case study of a family as a community music experience
Authors: Calì Claudia 
Published: November 2017

Abstract
This article examines and documents the musical life of a family with an 8-year-old child as resembling the concept, the intentions and practices of community music. Through the analysis of semi-structured interviews, sharing of musical artefacts, and written documentations of their daily musical encounters, I seek to provide insights into the functions of music as a means for building community, affective bonding and a sense of shared identity, drawing from Higgins the three broad perspectives through which community music is conceptualized. For the Beckett-Limas, an ethnically diverse family living in New York, music represented an adaptation tool in their living in various countries around the world, and sustained their transitions to different cultures, jobs, climates and communities, strengthening their relationships through moments of informal, spontaneous and communal musical interactions. Looking at family through the lens of community music reveals the extent to which music draws people together and promotes individual and collective well-being.
Musical concerts for young children in Greece
Authors: Dionyssiou Zoe , Fytika Athina 
Published: November 2017

Abstract
Music concerts for young children is a field of experimentation for many artistic institutions that aim to lead young audiences to rich musical experiences. This research project involved a series of concerts designed for young children from six months to six years old. The concerts were offered by the Music Department of Ionian University in Corfu city, Greece. The overall design and organization of the project aimed to offer an alternative and informal recital environment, so that young children and their parents could express their natural reactions towards music. Different layers of behaviour and reactions were observed and analysed, such as interactions among children, children and parents, children and musicians, and children and music.
Children with Williams syndrome make music: A community-based care model in the Czech Republic
Authors: Mastnak Wolfgang , Neuwirthová Anna 
Published: November 2017

Abstract
The Williams syndrome (WS) is a multifactorial genetic disorder that results from a deletion on location 7q11.23 and is characterized by a broad spectrum of pathological features. The strong affinity of affected individuals to music inspires promising therapeutic and community-based activities with instruments and the voice. Children with WS display an extraordinarily creative behaviour and have an eyecatching, outgoing personality. On the basis of a short review of research dedicated to music processing and music-associated benefits in WS, this article presents community-based music therapeutic approaches in Prague/Czech Republic. Taking sociocultural aspects of acculturation into account, it also discusses the multifaceted role of music therapists. Professional community music (CM) practice with WS encompasses manifold benefits such as social inclusion, developmental progress and personal growth, reduction of symptom-associated weakness, and subjective wellbeing through cultural participation.
Book Review
Authors: Waters Heather D. 
Published: November 2017

Abstract
Contesting Early Childhood: Listening to Children: Being and Becoming, Bronwyn Davies (2014) Abingdon, Oxon: Routledge, 121 pp., ISBN: 9781138780880 (Paperback, $53.95), ISBN: 9781315770390, e-book
Through illuminating stories from Reggio Emilia-inspired preschools, and connections to philosophy and literature, Davies encourages the practice of active, emergent listening, eloquently guiding the reader towards a deeper understanding of our relationships in and to the world. By encouraging openness to the not-yet-known, Davies potentially opens up new ways of thinking about children, communities, and ourselves.
Change in hydration indices associated with an increase in total water intake of more than 0.5 L/day, sustained over 4 weeks, in healthy young men with initial total water intake below 2 L/day
Authors: Stookey Jodi D. , Hamer Janice , Killilea David W. 
Published: November 2017

AbstractThis secondary data analysis addressed gaps in knowledge about effects of chronic water intake. Longitudinal data from the Adapt Study were used to describe effects of prescribing a sustained increase in water intake relative to baseline, for 4 weeks, on multiple indices of total body water (TBW) flux, regulation, distribution, and volume in five healthy, free‐living, young men, with mean total water intake initially below 2 L/day. Indices were measured weekly. Within‐person fixed effect models tested for significant changes in indices over time and associations between changes in indices. Agreement between indices was described. Mixed models tested if baseline between‐person differences in hydration indices modified changes in indices over time. Body water flux: The half‐life of water in the body decreased significantly. Body water regulation: Serum osmolality decreased significantly. Urine anti‐diuretic hormone, sodium, potassium, and osmolality decreased significantly. Plasma aldosterone and serum sodium increased significantly. Body water distribution: No significant changes were observed. Body water volume: Saliva osmolality decreased significantly. Body weight increased significantly by a mean ± SEM of 1.8% ± 0.5% from baseline over 4 weeks. Changes in indices were significantly inter‐correlated. Agreement between indices changed over 4 weeks. Baseline saliva osmolality significantly modified responses to chronic water intake. The results motivate hypotheses for future studies: Chronic TBW deficit occurs in healthy individuals under daily life conditions and increases chronic disease risk; Sustained higher water intake restores TBW through gradual isotonic retention of potassium and/or sodium; Saliva osmolality is a sensitive and specific index of chronic hydration status.
Cholesterol depletion does not alter the capacitance or Ca handling of the surface or t‐tubule membranes in mouse ventricular myocytes
Authors: Gadeberg Hanne C. , Kong Cherrie H. T. , Bryant Simon M. , James Andrew F. , Orchard Clive H. 
Published: November 2017

AbstractCholesterol is a key component of the cell plasma membrane. It has been suggested that the t‐tubule membrane of cardiac ventricular myocytes is enriched in cholesterol and that this plays a role in determining t‐tubule structure and function. We have used methyl‐β‐cyclodextrin (MβCD) to deplete cholesterol in intact and detubulated mouse ventricular myocytes to investigate the contribution of cholesterol to t‐tubule structure, membrane capacitance, and the distribution of Ca flux pathways. Depletion of membrane cholesterol was confirmed using filipin; however, di‐8‐ANEPPS staining showed no differences in t‐tubule structure following MβCD treatment. MβCD treatment had no significant effect on the capacitance:volume relationship of intact myocytes or on the decrease in capacitance:volume caused by detubulation. Similarly, Ca influx and efflux were not altered by MβCD treatment and were reduced by a similar amount following detubulation in untreated and MβCD‐treated cells. These data show that cholesterol depletion has similar effects on the surface and t‐tubule membranes and suggest that cholesterol plays no acute role in determining t‐tubule structure and function.
Products of Snowflaked Euclidean Lines Are Not Minimal for Looking Down
Authors: Joseph Matthieu , Rajala Tapio 
Published: November 2017

AbstractWe show that products of snowflaked Euclidean lines are not minimal for looking down. This question was raised in Fractured fractals and broken dreams, Problem 11.17, by David and Semmes. The proof uses arguments developed by Le Donne, Li and Rajala to prove that the Heisenberg group is not minimal for looking down. By a method of shortcuts, we define a new distance d such that the product of snowflaked Euclidean lines looks down on (RN, d), but not vice versa.
Accuracy and repeatability positioning of high-performancel athe for non-circular turning
Authors: Majda Paweł , Powałka Bartosz 
Published: November 2017

Abstract
This paper presents research on the accuracy and repeatability of CNC axis positioning in an innovative lathe with an additional Xs axis. This axis is used to perform movements synchronized with the angular position of the main drive, i.e. the spindle, and with the axial feed along the Z axis. This enables the one-pass turning of non-circular surfaces, rope and trapezoidal threads, as well as the surfaces of rotary tools such as a gear cutting hob, etc. The paper presents and discusses the interpretation of results and the calibration effects of positioning errors in the lathe’s numerical control system. Finally, it shows the geometric characteristics of the rope thread turned at various spindle speeds, including before and after-correction of the positioning error of the Xs axis.
New characterizations of magnetic Sobolev spaces
Authors: Nguyen Hoai-Minh , Pinamonti Andrea , Squassina Marco , Vecchi Eugenio 
Published: November 2017

Abstract
We establish two new characterizations of magnetic Sobolev spaces for Lipschitz magnetic fields in terms of nonlocal functionals. The first one is related to the BBM formula, due to Bourgain, Brezis and Mironescu. The second one is related to the work of the first author on the classical Sobolev spaces. We also study the convergence almost everywhere and the convergence in

L
1

{L^{1}}

appearing naturally in these contexts.
Data compression strategies for ptychographic diffraction imaging
Authors: Loetgering Lars , Rose Max , Treffer David , Vartanyants Ivan A. , Rosenhahn Axel , Wilhein Thomas 
Published: November 2017

Abstract
Ptychography is a computational imaging method for solving inverse scattering problems. To date, the high amount of redundancy present in ptychographic data sets requires computer memory that is orders of magnitude larger than the retrieved information. Here, we propose and compare data compression strategies that significantly reduce the amount of data required for wavefield inversion. Information metrics are used to measure the amount of data redundancy present in ptychographic data. Experimental results demonstrate the technique to be memory efficient and stable in the presence of systematic errors such as partial coherence and noise.
Does empirical data from bilingual and native Spanish corpora meet linguistic theory? The role of discourse context in variation of subject expression
Authors: García-Alcaraz Estela , Bel Aurora 
Published: November 2017

Abstract
The goal of this study is to shed light on how empirical data on the discourse constraints of null and overt third person subject pronouns in L1 and bilingual Spanish meet linguistic theory. A (semi)spontaneous production task was administered to 34 Moroccan Arabic (MA)/Spanish early sequential bilinguals and 30 L1 Spanish controls. All 3rd person subject positions were coded: (1) morphosyntactic form (null pronoun vs. overt pronoun); (2) discourse function ([-Topic Shift] vs. [+Topic Shift]); (3) sentence relation (intrasentential vs. intersentential); (4) clause order within intrasentential contexts (main-subordinate vs. subordinate-main); and (5) access to the antecedent (clear vs. ambiguous antecedent). The results reveal general patterns of use in both L1 and bilingual Spanish: null pronouns express topic maintenance both in inter- and intrasentential contexts (both clause orders) and overt pronouns, especially in intersentential contexts, are generally used for topic change. However, additional analyses provide evidence that null pronouns in L1, but not in bilingual Spanish, are often used in change of reference contexts where the antecedent is not ambiguous. This reveals patterns that have gone unreported by most previous descriptive and theoretical studies. Finally, a higher use of ambiguous null pronouns is attested among bilingual speakers, which suggests a lower control of the mechanisms by which reference is established in discourse and supports, to some extent, the predictions derived from the Interface Hypothesis.
An evaluation of the SENTiFIT 270 analyser for quantitation of faecal haemoglobin in the investigation of patients with suspected colorectal cancer
Authors: Auge Josep M. , Rodriguez Cristina , Espanyol Oihana , Rivero Liseth , Sandalinas Silvia , Grau Jaume , Jimenez Wladimiro , Castells Antoni 
Published: November 2017

Abstract

Background:
An evaluation of SENTiFIT® 270 (Sentinel Diagnostics, Italy; Sysmex, Spain) analyser for the quantitation of faecal haemoglobin (f-Hb) was performed.

Methods:
The analytical imprecision, linearity, carry over and f-Hb stability were determined. Evaluation of the diagnostic accuracy was performed on 487 patients.

Results:
Within-run and between-run imprecision ranged 1.7%–5.1% and 3.8%–6.2%, respectively. Linearity studies revealed a mean recovery of 101.1% (standard deviation, 6.7%) for all dilutions. No carry over was detected below 7650 μg Hb/g faeces. Decay of f-Hb in refrigerated samples ranged 0.2%–0.5% per day. f-Hb in patients with advanced colorectal neoplasia (ACRN) (colorectal cancer [CRC] plus advanced adenoma [AA]) were significantly higher than from those with a normal colonoscopy. Sensitivity for ACRN at f-Hb cutoffs from 10 to 60 μg Hb/g faeces ranged from 28.9% (95% confidence interval [CI], 21.7%–37.2%) to 46.5% (95% CI, 38.1%–55%), the specificity ranged from 85% (95% CI, 82.3%–87.3%) to 93.2% (95% CI, 91.2%–94.8%), positive predictive values for detecting CRC and AA ranged from 11.6% (95% CI, 7.6%–17.2%) to 20.6% (95% CI, 13.3%–30.3%) and from 34.7% (95% CI, 28.1%–42%) to 42.3% (95% CI, 32.4%–52.7%), respectively, and the negative predictive value for ACRN ranged from 90.2% (95% CI, 87.9%–92.2%) to 88.4% (95% CI, 86%–90.4%). Using two samples per patient sensitivity increased with a slight decrease in specificity.

Conclusions:
The analytical and clinical performances of SENTiFIT assay demonstrate a specific and accurate test for detecting ACRN in symptomatic patients and those undergoing surveillance.
Towards Pressure-Robust Mixed Methods for the Incompressible Navier–Stokes Equations
Authors: Ahmed Naveed , Linke Alexander , Merdon Christian 
Published: November 2017

Abstract
In this contribution, we review classical mixed methods
for the incompressible Navier–Stokes equations that relax the divergence constraint
and are discretely inf-sup stable. Though the relaxation of the divergence constraint was claimed to be harmless since
the beginning of the 1970s,
Poisson locking is just replaced by another more subtle kind of locking phenomenon, which
is sometimes called poor mass conservation
and led in computational practice to the exclusion
of mixed methods with low-order pressure approximations like the Bernardi–Raugel
or the Crouzeix–Raviart finite element methods. Indeed, divergence-free mixed methods
and classical mixed methods behave
qualitatively in a different way:
divergence-free mixed methods are
pressure-robust, which means that, e.g., their velocity error is independent
of the continuous pressure. The lack of pressure robustness in classical
mixed methods can be traced back to a consistency error
of an appropriately defined discrete Helmholtz projector.
Numerical analysis and numerical examples reveal that
really locking-free mixed methods must be discretely inf-sup stable and
pressure-robust, simultaneously. Further, a recent discovery shows that
locking-free,
pressure-robust mixed methods do not have to be divergence free.
Indeed, relaxing the divergence constraint in the velocity trial functions
is harmless, if the relaxation of the divergence constraint in
some velocity test functions is repaired, accordingly.
Thus, inf-sup stable, pressure-robust mixed methods will potentially
allow in future to reduce the approximation order of the discretizations used in computational
practice, without compromising the accuracy.