bluuebunny/crossref_metadata_2025_split huggingface dataset:
Генетические факторы в возникновении урологических онкологических заболеваний
Authors: Балановская Е.П. , Кадиров М.Л. , Соколова М.С. , Меликбекян А.К. , Агафонова Е.А. 
Published: October 2024

Введение. Урологические заболевания, включая рак простаты (РП) и мочевого пузыря (МП), являются серьезной проблемой глобального здравоохранения. Развитие генетических исследований открывает новые возможности для диагностики, лечения и профилактики этих заболеваний, подчеркивая важность понимания генетических факторов, лежащих в их основе. Цель работы. Провести комплексный анализ генетических факторов, влияющих на развитие урологических заболеваний, и оценить перспективы генетической диагностики и терапии в урологии. Материалы и методы. Исследование базируется на анализе современной литературы, данных геномных ассоциативных исследований (GWAS), а также применении технологий секвенирования нового поколения для выявления мутаций и полиморфизмов, связанных с РП и раком МП. Результаты. Выявлены ключевые генетические маркеры и мутации, ассоциированные с повышенным риском развития РП и рака МП, включая мутации в генах BRCA1, BRCA2 и FGFR3. Подчеркнута значимость индивидуальных генетических профилей для персонализации подходов к лечению. Заключение. Генетические исследования в урологии предоставляют фундаментальную основу для развития медицины персонализированных подходов в диагностике, лечении и профилактике урологических заболеваний. Продолжение исследований и разработка новых генетических терапевтических стратегий обещают значительный прогресс в сфере урологии.
Introduction. Urological diseases, including prostate cancer (PC) and bladder cancer (BC), pose a significant global health challenge. Advances in genetic research have opened new avenues for the diagnosis, treatment, and prevention of these diseases, underscoring the importance of understanding the genetic factors that underlie them. Purpose. To conduct a comprehensive analysis of the genetic factors influencing the development of urological diseases and evaluate the prospects of genetic diagnostics and therapy in urology. Materials and methods. This study is based on an analysis of contemporary literature, data from genome-wide association studies (GWAS), and the application of next-generation sequencing technologies to identify mutations and polymorphisms associated with PC and BC. Results. Key genetic markers and mutations associated with an increased risk of developing PC and BC were identified, including mutations in the BRCA1, BRCA2, and FGFR3 genes. The significance of individual genetic profiles for personalizing treatment approaches was highlighted. Conclusion. Genetic research in urology provides a fundamental basis for the development of personalized medicine approaches in the diagnosis, treatment, and prevention of urological diseases. The continuation of research and the development of new genetic therapeutic strategies promise significant progress in the field of urology.
Исследование пожарной опасности электронных устройств для курения
Authors: Горбунов А.С. , Богданов А.А. 
Published: October 2024

В статье представлены результаты исследований пожарной опасности электронных устройств для курения. В современном мире наблюдается высокий рост потребителей электронных устройств для курения. Помимо своей популярности электронные устройства могут представлять опасность в виде возникновения пожаров. Целью исследования является получение полного представления о возможности возникновения пожара от электронных устройств для курения, а также о рисках и опасностях, связанных с данными устройствами. Результаты и выводы работы могут быть использованы для разработки мер по повышению безопасности использования и производства вейпов.
The article presents the results of research on the fire hazard of electronic smoking devices. In the modern world, there is a high growth in consumers of electronic smoking devices. In addition to their popularity, electronic devices can pose a danger in the form of fires. The aim of the study is to obtain a complete understanding of the possibility of fire from electronic smoking devices, as well as the risks and dangers associated with these devices. The results and conclusions of the work can be used to develop measures to improve the safety of using and production vapes.
Априорная оценка оправдываемости прогнозов количества лесных пожаров в Якутии на 2024 и 2025 гг. с учетом изменений потоков космических лучей и солнечной активности
Authors: Холопцев А.В. , Проскова Н.Ю. , Шубкин Р.Г. 
Published: October 2024

Долгосрочные прогнозы изменений количества лесных пожаров, выявляемых за год на территории Якутии, необходимо учитывать при принятии управляющих решений по обеспечению пожарной безопасности региона. Цель данной работы - разработка и оценка оправдываемости прогнозов количества лесных пожаров для территории Якутии на 2024 и 2025 годы с учетом изменений потоков космических лучей и солнечной активности. Для ее достижения, среди указанных факторов определены предикторы прогностической модели изучаемых процессов, учет которых обеспечивал удовлетворительную оправдываемость рассматриваемых прогнозов на 2017 – 2023гг. Полученные результаты свидетельствуют о том, что в 2000 – 2023 гг. сценарий изучаемого процесса был близок к консервативному. Из разработанных прогнозов следует, что, если сценарий дальнейших изменений пожарной опасности в Якутии сохранится таким же, количество лесных пожаров, которые в 2024 и в 2025 годах возникнут на ее территории, не превысит уровень 2023 года. Разработанные прогнозы целесообразно учитывать при планировании основных мероприятий соответствующих функциональных подсистем Единой государственной системы предупреждения и ликвидации чрезвычайных ситуаций.
Long-term forecasts of changes in the number of forest fires detected per year on the territory of Yakutia should be taken into account when making management decisions to ensure fire safety in the region. The purpose of this work is to develop and assess the feasibility of forecasts of the number of forest fires for the territory of Yakutia for 2024 and 2025, taking into account changes in cosmic ray fluxes and solar activity. To achieve this goal, among the factors mentioned above, the predictors of the prognostic model of the processes under study were determined, taking into account which provided satisfactory justifiability of the forecasts under consideration for 2017 - 2023. The obtained results indicate that in 2000 - 2023 the scenario of the studied process was close to the conservative one. It follows from the developed forecasts that if the scenario of further changes in fire danger in Yakutia remains the same, the number of forest fires that will occur on its territory in 2024 and 2025 will not exceed the level of 2023. It is advisable to take into account the developed forecasts when planning the main activities of the relevant functional subsystems of the Unified State System for Prevention and Elimination of Emergency Situations.
The efficient method for searching stable structures in herringbone-phase organic semiconductors using density functional theory
Authors: Hakata Shuya , Ishii Hiroyuki , Takaki Hirokazu , Okamoto Toshihiro , Takeya Jun , Kobayashi Nobuhiko 
Published: October 2024

Abstract
We present the herringbone structure search (HSS) method to predict the crystal structures of organic semiconductors from molecular structural formulas. The charge transport efficiency of small-molecule organic semiconductors is governed by molecular packing, often in a two-dimensional herringbone structure. This method predicts crystal structures within the herringbone framework using the density functional theory. As a demonstration, we successfully applied it to promising molecules, predicting crystal structures that agreed well with experimental data. This method offers an efficient approach for in silico screening of new organic molecules, aiding the development of high-performance organic semiconductors.
The effect of severe COVID-19 infection on biochemical markers (FBS, HbA1C, FA, INS, C-Pep) in diabetic patients
Authors: Yones Marwah S. , Al-Wasiti Estabraq , Al Qaseer Abdul Hameed , Al-Rubaiawi Hadel Kareem 
Published: October 2024

Background & objective: Several studies have been conducted around the world on the impact of COVID-19 on people with diabetes mellitus (DM). Any acute illness can cause stress and increased inflammatory reactions, which increase sympathetic outflow and produce catecholamines, growth hormones, cortisol, and cytokines, all of which raise the risk and severity of complications from diabetes. Diabetes is a significant risk factor for the severity of COVID-19. We conducted this study to identify whether severe COVID-19 infection has any effect on the biomarkers, including fasting blood sugar (FBS), HbA1C, FA, INS, C-Pep, in individuals with DM.
Methodology: This study was simultaneously conducted at Department of Chemistry and Biochemistry, College of Medicine of Al-Nahrain University, and Department of Medicine of Mustansiriyah University College of Medicine, Baghdad, Iraq. During the months of February and March 2022, 50 COVID-19 patients with diabetes and 50 COVID-19 patients without diabetes were included in the study. The control group included 100 healthy, sexually identical people (age 50-80), collected under the supervision of the second supervisor from relatives and students of Mustansiriyah University, College of Medicine. Venous blood samples of 5 mL were taken from all participants and subjected to laboratory tests to detect the levels of the biomarkers.
Results: Average FBS level in DM patients was 304.9 mg/dL, (range 132-545.9 mg/dL), which was remarkably higher than in non-DM patient groups (193.3 mg/dL), range (of 66.2–458). The DM patients' group had a significantly higher concentration of HbA1C (median = 6.70 mg/dL, range 5.2-8.1) than the non-DM patient group (median = 5.8, range 4.2–7.6) with a significant difference. Although The group of DM patients had significantly greater FA concentrations than the group of non-DM patients. In contrast, the median and range for insulin and c-peptide Displays non-significant differences for covid-19 patients (DM and non-DM), but it's significant with a control group.
Conclusion: According to this study, COVID-19 patients with diabetes had greater biochemical indicator levels than non-diabetic people. Pre- and postprandial hyperglycemia and diabetic ketoacidosis were more common in COVID-19 DM patients than in non-infected DM patients. We found that COVID-19 increased the severity risk for T2DM patients and glucose level is raised and progresses in a vicious cycle exacerbated by insulin resistance (IR) and decreased pancreatic b-cell function.
Keywords: COVID-19, Diabetes mellitus, FBS, HbA1C, FA, INS, C-Pep
Citation: Yones MS, Al-Wasiti E, Al Qaseer AH, Al-Rubaiawi HK. The effect of severe COVID-19 infection on biochemical markers (FBS, HbA1C, FA, INS, C-Pep) in diabetic patients. Anaesth. pain intensive care 2024;28(5):804−808; DOI: 10.35975/apic.v28i5.2553
Received: June 01, 2024; Reviewed: June 19, 2024; Accepted: June 19, 2024
Development of ventilator-associated pneumonia (VAP) prevention model in the hospital based on Six Sigma and VAP Bundle
Authors: Yuswanto Tri Johan Agus , Ernawati Naya , Solikhah Fitriana Kurniasari , Wahito Nugroho Heru Santoso 
Published: October 2024

Background & Objective: Ventilator-Associated Pneumonia (VAP) is the leading cause of death in Healthcare-Associated Infections (HCAI), with 30-day mortality of 59% of patients with ventilator devices. The aim of this research was to develop a VAP prevention model in the intensive care unit (ICU) based on Six Sigma and VAP Bundle, involving individual, organizational and work characteristics factors.
Methodology: This research was carried out in the ICU, Poltekkes Kemenkes Malang, Malang, Indonesia, using a cross-sectional design. The research subjects were nurses, selected using a simple random sampling technique. All variables were measured through filling out questionnaires. Next, the measurement data was analyzed using Partial Least Square (PLS), based on Six Sigma and VAP Bundle.
Results: Based on Six Sigma and VAP Bundle, the results of the analysis of the effects of the three factors on the implementation of VAP prevention were: 1) for individual factors, path coefficient = 0.189 and P = 0.000, so it was interpreted that this factor had a significant effect on the implementation of VAP prevention; 2) for organizational factors, path coefficient = 0.496 and P = 0.003, so it was interpreted that this factor also had a significant effect; 3) for the work characteristics factors, path coefficient = 0.289 and P = 0.000, so this factor also had a significant effect on the implementation of VAP prevention.
Conclusion: Based on the research results, a VAP prevention model based on Six Sigma and VAP bundle was successfully built in the ICU, which involved organizational factors, work characteristics and individual factors.
Abbreviations: HCAI - Healthcare-Associated Infections; HAP - Hospital-acquired pneumonia; PLS - Partial Least Square; SOP - standard operating procedure; VAP - ventilator-associated pneumonia;
Keywords: Ventilator-Associated Pneumonia, VAP, Prevention; Six Sigma, VAP Bundle; Intensive Care Unit; organizational factors; work characteristics; individual factors
Citation: Yuswanto TJA, Ernawati N, SolikhahFK, Nugroho HSW. Development of a prevention model for ventilator-associated pneumonia based on Six Sigma and VAP bundle. Anaesth. pain intensive care 2024;28(5):876−882; DOI: 10.35975/apic.v28i5.2574
Received: July 14, 2024; Reviewed: July 28, 2024; Accepted: July 28, 2024
Síndrome do ápice orbitário, apresentação aguda e implicações tardias: um estudo bibliográfico.
Authors: Queiroz Filho Euclides Quirino De , Lustosa Maria Aparecida Lira Gomes , Nogueira Gabriela Marques , Barbosa Taisa Pêgo 
Published: October 2024

A síndrome do ápice orbitário (SAO) é uma condição neurológica rara e complexa que afeta múltiplos nervos cranianos, causando sintomas como oftalmoplegia dolorosa, proptose, ptose, perda de visão e hipoestesia na região periorbital. Suas principais causas incluem inflamações, infecções, neoplasias e processos vasculares. O diagnóstico e tratamento precoces são essenciais para evitar complicações permanentes, como perda de visão e neuropatias ópticas. O manejo da SAO exige uma abordagem multidisciplinar, envolvendo oftalmologistas, neurologistas e radiologistas, sendo o tratamento guiado pela identificação da causa subjacente. O objetivo desta revisão sistemática é analisar a apresentação aguda da síndrome do ápice orbitário, suas causas, diagnóstico, tratamento e as implicações tardias nos desfechos clínicos dos pacientes, com base em um estudo abrangente da literatura existente. Foram utilizadas as seguintes bases de dados científicas: Scopus e PubMed, para a seleção dos artigos, como o uso dos unitermos em língua inglesa: “Orbital apex syndrome, Acute presentation, Long-term complications, Ophthalmologic diagnosis”. Conclui-se que a síndrome do ápice orbitário (SAO) é uma condição aguda caracterizada por oftalmoplegia dolorosa e perda visual, resultante da compressão dos nervos cranianos que passam pelo ápice orbitário. O diagnóstico precoce, por meio de ressonância magnética, é essencial para diferenciar a SAO de outras condições semelhantes, como a síndrome do seio cavernoso. O tratamento varia de corticosteroides a intervenções cirúrgicas em casos de infecção ou tumores. A abordagem multidisciplinar é fundamental para otimizar os desfechos, prevenindo complicações como fibrose residual e perda visual irreversível. O manejo eficaz da SAO requer um acompanhamento a longo prazo e um plano terapêutico individualizado para melhorar a qualidade de vida dos pacientes.
The Security Implications of Self Driving Cars in India
Authors: Dr. S.S. Jadhav  , Jai Prakash  
Published: October 2024

The development of autonomous cars has been made possible in order to improve the safety of those who utilize transportation. These cars are able to have the ability to perceive their surroundings and make judgments without any assistance from outside sources in order to generate the most efficient path to reach a location. Prior to putting the solution into action, it is necessary to exercise caution, despite the fact that the concept seems to be futuristic and, if it is effectively implemented, would address a great deal of the existing problems that are associated with transportation. In this study, we will examine both the positive and negative aspects of putting autonomous cars into operation. Any tampering or manipulation of the data collected and communicated by these sensors might have fatal effects, since human lives are at risk in this situation. The sensors that are present on the cars are very dependent on the sensors that are present on the vehicles. This article covers a variety of assaults that may be launched against the various types of sensors that are installed on an autonomous vehicle.
Structural and logical scheme of construction of technical means of control of unproductive fuel consumption by machine and tractor units
Authors:   MECHANICS and AUTOMATICS of AGROINDUSTRIAL PRODUCTION of the NATIONAL ACADEMY of AGRARIAN SCIENCES of UKRAINE, Myronenko V. , Zhovtyi O. ,   MECHANICS and AUTOMATICS of AGROINDUSTRIAL PRODUCTION of the NATIONAL ACADEMY of AGRARIAN SCIENCES of UKRAINE
Published: October 2024

Purpose. Reduce unproductive fuel consumption in agroindustrial production in Ukraine. Methods. System analysis of opportunities to reduce fuel consumption in crop production. Synthesis of the structural and logical scheme of information support for unproductive fuel consumption by machine and tractor units. Results. Structural-logical scheme of information support for unproductive fuel consumption by machine and tractor units in the performance of the main technological operations of crop production. Conclusions 1.	Fuel consumption per unit of production in Ukrainian agriculture needs to be significantly reduced. 2.	Unproductive fuel consumption generally occurs for organizational (up to 40 %), qualification (up to 40 %) and technical (up to 15 %) reasons. 3.	Operational control and analysis of fuel consumption with the help of additional technical intelligence during ordinary operation of MTA can reduce fuel consumption by up to 51 %. Keywords: machine and tractor unit, fuel, operational control, unproductive costs, information support.
METHODS OF CONDUCTING MARKETING RESEARCH
Authors: Заякина Ирина Александровна , Петрова Ксения Алексеевна 
Published: October 2024

В данной статье рассматриваются ключевые аспекты разведочных, описательных и казуальных исследований, их сходства и различия, особенности применения.
This article discusses the key aspects of exploratory, descriptive and casual research, their similarities and differences, and application features.
MODERN METHODS OF NATURAL LANGUAGE PROCESSING IN COMPARATIVE LINGUISTICS
Authors: Агошкова Татьяна Валерьевна 
Published: October 2024

Современные технологии обработки натуральных языков существенно расширили возможности сравнительно-сопоставительного языкознания. В статье рассматриваются методы сравнительно-сопоставительного анализа, включая морфологический, семантический, синтаксический и прагматический методы исследования.
Modern technologies of natural language processing have significantly expanded the possibilities of comparative linguistics. The article examines the methods of comparative analysis, including morphological, semantic, syntactic and pragmatic research methods.
RUSSIAN NATIONAL CHARACTER IN THE CONTEXT OF INTERCULTURAL COMMUNICATION
Authors: Савостьянов Александр Иванович , Мацаренко Татьяна Николаевна 
Published: October 2024

межкультурная коммуникация в российском образовании совсем новая и неисследованная дисциплина. авторы впервые поднимают вопрос русского национального характера на платформе межкультурной коммуникации, стремятся понять и осмыслить данный феномен, который значим для современного общества.
intercultural communication in russian education is a completely new and unexplored discipline. the authors raise the issue of russian national character on the platform of intercultural communication for the first time, and seek to understand and comprehend this phenomenon, which is significant for modern society.
Inteligencia Emocional de los Estudiantes del Noveno Grado del Distrito de Coronel Oviedo – Paraguay
Authors: Avalos Ferreira Celia Nemecia , González de Benítez Rosa Catalina , Iglesias Romero Natalia Mabel 
Published: October 2024

Este trabajo intenta arrojar luz sobre las condiciones en que se encuentra el desarrollo de la inteligencia emocional de los estudiantes del noveno grado del distrito de Coronel Oviedo (zonas rural y urbana). Para este estudio, se tiene como base el concepto de BarOn (citado por Ugarriza, 2001), sobre el cual, él construye un inventario de cociente emocional (I - CE) y su visión sistémica, es la utilizada en esta investigación, considerando los cinco componentes de la inteligencia emocional y quince subcomponentes que la constituyen para describir la situación de la inteligencia emocional de los estudiantes de esta franja etaria, pudiendo afirmar que los mismos tienen dificultades en el desarrollo de los componentes, con un nivel más notorio entre los jóvenes en la zona urbana. La investigación se ha llevado a cabo bajo una metodología exclusivamente cuantitativa con el fin de extraer información precisa sobre el fenómeno estudiado y sugerir una línea de acción a la comunidad educativa usando como base los resultados de la investigación.
La Equidad de Género en el Trabajo para Acceder a Oportunidades que Impactan en el Desarrollo y Liderazgo de la Mujer
Authors: Gómez Gutierrez Elizabeth Lourdes , Castillo Borrego Juan Francisco , Rodriguez Camacho Victoria 
Published: October 2024

Los estudios de género en el ambiente laboral, constituye una creación de espacios para romper con comportamientos arraigados, en este sentido, los estudios de género han tomado relevancia desde hace varias décadas; es evidente el trabajo que los diferentes sectores: laboral, social, académico, público y privado, se han llevado con el propósito de abonar a la equidad de género en todos los ámbitos. Por ello la investigación tiene como objetivo mostrar la importancia de la igualdad de género en todos los ambientes y específicamente en el laboral. La lucha constante de la mujer por ascender a puestos directivos, su preparación, desarrollo y liderazgo para lograr igualdad de oportunidades.
Metodología de alcance descriptiva utiliza la encuesta como instrumento de medición, se aplicó a 255 personas en Saltillo, Coahuila en mayo de 2023, muestra representativa seleccionada de manera intencional a profesionistas de industrias manufactureras, los resultados se exportaron al programa estadístico SPSS 23.0 para ser analizados, se obtuvo un Alpha de Cronbach de .788, se determinó el estadístico Káiser-Meyer- Olkin (KMO), arrojando un valor de 0.764 siendo superior de 0.5.
Resultados y conclusiones: el 60% respondieron que solamente de 1a 5 mujeres ocupan un puesto directivo en sus organizaciones, seguido del 15.7% que ninguna mujer. El 75% perciben que ambos tienen la capacidad del liderazgo, no hay diferencias en capacidades y habilidades de líder, sin embargo responden que un 77.6% de los que ocupan el nivel jerárquico más alto, son hombres, solo el 22.4% es mujer, mostrando una brecha de género existente.