bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐class plant hormone HILIC‐MS/MS analysis coupled with high‐throughput phenotyping to investigate plant–environment interactions
Authors: Vrobel Ondřej , Ćavar Zeljković Sanja , Dehner Jan , Spíchal Lukáš , De Diego Nuria , Tarkowski Petr 
Published: September 2024

SUMMARYPlant hormones are chemical signals governing almost every aspect of a plant's life cycle and responses to environmental cues. They are enmeshed within complex signaling networks that can only be deciphered by using broad‐scale analytical methods to capture information about several plant hormone classes simultaneously. Methods used for this purpose are all based on reversed‐phase (RP) liquid chromatography and mass spectrometric detection. Hydrophilic interaction chromatography (HILIC) is an alternative chromatographic method that performs well in analyses of biological samples. We therefore developed and validated a HILIC method for broad‐scale plant hormone analysis including a rapid sample preparation procedure; moreover, derivatization or fractionation is not required. The method enables plant hormone screening focused on polar and moderately polar analytes including cytokinins, auxins, jasmonates, abscisic acid and its metabolites, salicylates, indoleamines (melatonin), and 1‐aminocyclopropane‐1‐carboxylic acid (ACC), for a total of 45 analytes. Importantly, the major pitfalls of ACC analysis have been addressed. Furthermore, HILIC provides orthogonal selectivity to conventional RP methods and displays greater sensitivity, resulting in lower limits of quantification. However, it is less robust, so procedures to increase its reproducibility were established. The method's potential is demonstrated in a case study by employing an approach combining hormonal analysis with phenomics to examine responses of three Arabidopsis ecotypes toward three abiotic stress treatments: salinity, low nutrient availability, and their combination. The case study showcases the value of the simultaneous determination of several plant hormone classes coupled with phenomics data when unraveling processes involving complex cross‐talk under diverse plant‐environment interactions.
TSUNAMI Analyses of the Similarity and Applicability of Zero Energy Deuterium 2 Critical Experiments for Reactor Physics Code Benchmarking for a Pressurized Water Reactor Small Modular Reactor Design Concept
Authors: Masala Eugene , Blomeley Laura , Watts David G. , Bromley Blair P. 
Published: September 2024

Abstract
This paper presents the findings of studies conducted at Canadian Nuclear Laboratories (CNL) to support the development of small modular reactor (SMR) designs. The primary focus of this research was to evaluate the suitability of the zero energy deuterium 2 (ZED-2) critical facility in replicating the reactor physics environment for a pressurized water reactor small modular reactor (PWR-SMR) design concept through similarity and nuclear data sensitivity studies, using the TSUNAMI code suite. It was found that previous ZED-2 experiments would be quite promising for application to a PWR-SMR design. Further similarity and sensitivity studies of hypothetical mixed-lattice substitution experiments, where PWR-SMR fuel assemblies were placed into a substitution region of the ZED-2 critical facility demonstrated improved similarity. Subsequent analyses focused on the impacts of dissolved Gadolinium (Gd) and boron (B) neutron absorbers, suggesting the feasibility of using future ZED-2 experiments to more closely replicate PWR-SMR reactor physics behavior. Building on these initial findings, the design for PWR-SMR fuel assembly substitution experiments in the ZED-2 facility were explored further. These hypothetical experiments feature water-cooled PWR-type fuel assemblies inside a shroud, surrounded by heavy-water-moderated CANdu FLEXible, Low Enriched Uranium, Recovered Uranium (CANFLEX-LEU/CANFLEX-RU) fuel channels. Similarity and sensitivity studies indicate a very high level of similarity of these experiments for PWR-SMR design applications.
Fusion of Multiple Data Sources for Vehicle Crashworthiness Prediction Using CycleGAN and Temporal Convolutional Networks
Authors: Zeng Jice , Gao Zhenyan , Li Yang , Barbat Saeed , Lu Jin , Hu Zhen 
Published: September 2024

Abstract
Computer-aided engineering (CAE) models play a pivotal role in predicting crashworthiness of vehicle designs. While CAE models continue to advance in fidelity and accuracy, an inherent discrepancy between CAE model predictions and the responses of physical tests remains inevitable, due to assumptions or simplifications made in physics-based CAE models. Machine learning (ML) models have shown promising potential in improving the prediction accuracy of CAE models. Nevertheless, the scarcity of vehicle crash data poses a significant challenge to the training of such ML models. This paper aims to overcome these challenges by fusing multiple data sources from two different types of vehicles. More specifically, the cycle-consistent generative adversarial neural networks (CycleGAN) are first employed to translate features of time-series test data from one domain (the first vehicle type) to another (the second vehicle type) using cycle consistency loss. Such a translation allows for the generation of synthetic crash test data for the second vehicle type by leveraging existing tests from both the first and second vehicle types. In parallel, an initial temporal convolutional network (TCN) model is trained using CAE simulation data and physical test data of the first vehicle type. This pre-trained TCN model is then fine-tuned using three sources of data from the second vehicle type, namely the CAE data, test data, and the augmented virtual test data generated using CycleGAN. Through this data fusion, the crashworthiness prediction accuracy of the second vehicle type can be improved. The essence of the proposed method involves domain translation across two different yet potentially interrelated vehicle types. This is accomplished by leveraging insights gained from the first vehicle type through transfer learning, coupled with data augmentation techniques. The proposed method is demonstrated by a real-world case study with a small-size SUV and a medium-size SUV. Results show substantial enhancement in the predictive performance of the medium-size SUV model.
Oral but Not Topical Sodium Bicarbonate Improves Repeated Sprint Performance During Simulated Soccer Match Play Exercise in Collegiate Athletes
Authors: Gurton William H. , Gough Lewis A. , Siegler Jason C. , Lynn Anthony , Ranchordas Mayur K. 
Published: September 2024

This study investigated the effect of oral and topical sodium bicarbonate (SB) on soccer-specific performance during simulated soccer exercise. In a block randomized, double-blind, crossover design, 10 collegiate male soccer players (stature: 181.7 ± 3.2 cm, body mass: 81.7 ± 10.5 kg) performed soccer-specific performance tests (countermovement jumps, Illinois agility, 8 × 25 m repeated sprints) throughout a 90-min soccer-specific aerobic field test (SAFT90) following 0.3 g/kg body mass SB in capsules (SB-ORAL), 0.9036 g/kg body mass PR Lotion (SB-LOTION), or placebo capsules and lotion (PLA). Soccer-specific performance tests were conducted pre-SAFT90, during half-time and post-SAFT90. Blood samples were analyzed for acid–base balance (pH; bicarbonate, ) and strong ions (sodium, Na+; potassium, K+). Average sprint times were quicker for SB-ORAL than PLA during half-time (3.7%; p = .049; g = .57) and post-SAFT90 (4.9%; p = .041; g = .66). SB-ORAL increased pH and prewarm-up and during half-time (p < .05), and lowered K+ during half-time (p = .035) compared with PLA. SB-LOTION increased pH (p = .019) and lowered K+ (p = .012) during half-time compared with PLA. SB-LOTION increased Na+ postexercise compared with PLA (p = .008). Repeated sprint times during simulated soccer exercise improved for SB-ORAL, which might have been mechanistically underpinned by elevated blood buffering capacity and greater regulation of strong ion concentration. Consuming SB in capsules is a more effective strategy than topical SB application for improving blood buffering capacity and repeated sprint performance throughout competitive soccer matches.
Spin-Dipole Strengths and Neutron Skin Thickness of $${}^{{90}}$$Zr, $${}^{{132}}$$Sn, $${}^{{208}}$$Pb
Authors: Borzov I. N. , Tolokonnikov S. V. 
Published: September 2024

Abstract
The strength distributions of charge exchange spin-dipole excitations are calculated in the continuum quasiparticle random-phase approximation based on the Fayans density functional with modified isovector part. An impact of the isovector parameter $$h_{2}^{-}$$ of the DF3-f functional on the strength functions of charge-exchange spin-dipole excitations ($$0^{-}$$, $$1^{-}$$, $$2^{-}$$) are studied for $${}^{208}$$Pb, $${}^{132}$$Sn and $${}^{90}$$Zr. The sum rules are calculated using both ground state radii and direct integration of the total SD strength distributions. A comparison with the experimental SD sum rule in $${}^{90}$$Zr gives one a possibility to check previously estimated $$h_{2}^{-}$$ values which described well the recent combined estimate for $$\Delta R_{np}$$ in $${}^{208}$$Pb and corresponding equation of state parameters – symmetry energy $$J_{0}=J(\rho_{0})$$ and a slope parameter $$L_{0}=L(\rho_{0})$$.
Characteristics of the studies using realist evaluation to assess interventions that address psychosocial healthcare issues in older adults: a scoping review
Authors: Mitani Shinya , Ogawara Hirofumi , Haruta Junji , Sakakibara Tetsuya , Fukahori Hiroki 
Published: September 2024

Objectives
Interventions to address psychosocial healthcare issues in older adults are increasing. Realist evaluation (RE) helps us understand how these interventions work for their issues. It is significant to obtain implications for further developing such research. We aimed to identify the characteristics of studies using RE to assess interventions that address psychosocial healthcare issues in older adults by mapping relevant literature.

Design
Scoping review.

Data sources
MEDLINE, the Cumulative Index to Nursing and Allied Health Literature, PsycINFO, Web of Science, Cochrane Library, ICHUSHI (a Japanese database) and Google Scholar were used for searches between 5 January 2022 and 4 January 2024.

Eligibility criteria
(1) Showing that most of the participants were older adults or their stakeholders; (2) stating in the research background or aim sections that the target interventions aimed at addressing older adults’ psychosocial healthcare issues and (3) using RE to assess these interventions.

Data extraction
Data on country of origin, type of research, study design, qualitative data collection and analysis methods, desirable items for RE and intervention aims and purposes were extracted and summarised using descriptive statistics.

Results
Fifty-four studies were analysed. Most studies were conducted in the UK (54.5%). Mixed methods were used in 28 studies (51.9%), while only qualitative methods were used in 25 studies (46.2 %). Fourteen intervention aims and purposes were identified: improving dementia care, avoiding emergency admissions, preventing social isolation and promoting family involvement in the care of older adults.

Conclusion
RE is useful for promoting an understanding of how interventions work for addressing psychosocial healthcare issues in older adults. RE also promotes the updating of plausible theories that lead to improving interventions. Our findings show the implications of managing time and resources to address the challenge of RE’s time and resource intensiveness and carefully considering the data collection methods to reduce burdens on older adults.
Cost-effectiveness of consolidation durvalumab for inoperable stage III non-small cell lung cancer in Vietnam
Authors: Mai Vu Quynh , Lindholm Lars , Van Minh Hoang , Sun Sun , Giang Kim Bao , Sahlén Klas-Göran 
Published: September 2024

Background
This study aimed to assess the cost-effectiveness of durvalumab as a treatment option for patients with inoperable stage III non-small cell lung cancer (NSCLC) from healthcare and partial societal perspectives in Vietnam.

Method
A lifetime partitioned survival model was used to evaluate the costs and quality-adjusted life years (QALYs) associated with consolidation durvalumab in comparison with the standard of care alone. Local costs and utilities were incorporated into the model. In the base-case analysis, no discount was applied to the acquisition cost of durvalumab. Scenario-based, one-way and probabilistic-sensitivity analyses were conducted.

Results
The base-case analysis revealed that the intervention resulted in an increase of 1.38 life years or 1.08 QALYs for patients, but the intervention was not deemed cost-effective from either perspective in the base-case analysis. However, with a 70% reduction in the durvalumab acquisition cost, the intervention was observed to be cost-effective when evaluated from a healthcare perspective and when examining the undiscounted results from a partial societal standpoint.

Conclusion
This study provides evidence regarding the cost-effectiveness of durvalumab for the treatment of inoperable stage III NSCLC in Vietnam for various scenarios. The intervention was not cost-effective at full acquisition cost, but it is important to acknowledge that cost-effectiveness arguments alone cannot solely guide decision-makers in Vietnam; other criteria, such as budget impact and ethical concerns, are crucial factors to consider in decision-making processes.
Rehospitalisation risk by hypnotics class in older patients with heart failure: a cohort study utilizing administrative claims data in Japan
Authors: Saito Tomoyuki , Nojiri Shuko , Naito Ryo , Kasai Takatoshi 
Published: September 2024

Background
Studies comparing the safety of orexin receptor antagonists and other hypnotic types for older patients with heart failure (HF) remain lacking. This study aimed to compare orexin receptor antagonists (suvorexant) with benzodiazepines or Z-drugs for sleep treatment and investigate the risk of acute HF-related rehospitalisation in older patients with HF.

Methods
This study used a cohort design to analyse data from an administrative claims database from April 2008 to December 2020. The study population was determined based on inclusion and exclusion criteria from a cohort of 1 159 937 patients aged ≥65 years, selected through random sampling. The follow-up period was censored based on multiple criteria, including outcome occurrences and hypnotic classification changes. Kaplan-Meier survival analysis and Cox proportional hazards models were conducted for risk assessment.

Results
The analysis included 1858 patients, aged ≥65 years and experiencing their first HF-related hospitalisation. These patients were categorised based on the initially prescribed hypnotic classification, including suvorexant, benzodiazepines and Z-drugs in 490, 606 and 762 patients, respectively. The average age and SD were similar across all hypnotic classes at 82.7±7.6 years. Kaplan-Meier curves indicated a higher trend of rehospitalisation risk for benzodiazepines and Z-drugs than for suvorexant. The adjusted HRs were 2.77 (95% CI 1.17 to 6.52) for benzodiazepines and 2.98 (95% CI 1.33 to 6.68) for Z-drugs.

Conclusions
Suvorexant administration for sleep treatment in older patients with HF shows a potentially reduced risk of acute HF-related rehospitalisation compared with benzodiazepines and Z-drugs. The results of this study provide valuable information for selecting hypnotics in older patients with HF having concurrent sleep disorders.
Investigating early and late-time epochs in f(Q) gravity
Authors: Kolhatkar Ameya , Mishra Sai Swagat , Sahoo P. K. 
Published: September 2024

AbstractIn the following work, a new hybrid model of the form $$ f(Q)=Q(1+a)+b\frac{Q_0^2}{Q} $$

f

(
Q
)

=
Q

(
1
+
a
)

+
b

Q
0
2

Q

has been proposed and confronted using both early as well as late-time constraints. We first use conditions from the era of Big Bang Nucleosynthesis (BBN) in order to constrain the models which are further used to study the evolution of the Universe through the deceleration parameter. This methodology is employed for the hybrid model as well as a simple model of the form $$ \alpha _1 Q+\alpha _2 Q_0 $$

α
1

Q
+

α
2

Q
0

which is found to reduce to $$\Lambda $$
Λ
CDM. The error bar plot for the Cosmic Chronometer (CC) and Pantheon+SH0ES datasets which includes the comparison with $$\Lambda $$
Λ
CDM, has been studied for the constrained hybrid model. Additionally, we perform a Monte Carlo Markov Chain (MCMC) sampling of the model against three datasets – CC, Pantheon+SH0ES, and Baryon Acoustic Oscillations (BAO) to find the best-fit ranges of the free parameters. It is found that the constraint range of the model parameter (a) from the BBN study has a region of overlap with the ranges obtained from the MCMC analysis. Finally, we perform a statistical comparison between our model and the $$\Lambda $$
Λ
CDM model using AIC and BIC method.
Higgs photon associated production in a two Higgs doublet type-II seesaw model at future electron-positron colliders
Authors: Ouazghour B. Ait , Chabab M. , Goure K. 
Published: September 2024

AbstractWe study the one-loop prediction for the single production of a SM-like Higgs boson in association with a photon in electron-positron collisions in the context of the two Higgs doublet type-II seesaw model (2HDMcT). We explore to what extent the new scalars in the 2HDMcT spectrum affect its production cross-section, the ratio $$R_{\gamma h_1}$$

R

γ

h
1

as well as the signal strengths $$R_{\gamma Z}$$

R

γ
Z

and $$R_{\gamma \gamma }$$

R

γ
γ

when $$h_1$$

h
1

is identified with the observed SM Higgs boson within the 2HDMcT delimited parameter space. More specifically, we focus on $$e^+e^- \rightarrow h_1\gamma $$

e
+

e
-

→

h
1

γ

process at one-loop, and analyzed how it evolves under a full set of theoretical constraints and the available experimental data, including $$B\rightarrow X_s\gamma $$

B
→

X
s

γ

limit at 95$$\%$$
%
C.L. Our analysis shows that these observables are strongly dependent on the parameters of the model, especially the mixing angel $$\alpha _1$$

α
1

, the potential parameters $$\lambda _{7}$$

λ
7

, $$\lambda _{9}$$

λ
9

, the trilinear Higgs couplings, with a noticeable sensitivity to $$\alpha _1$$

α
1

. We found that $$\sigma (e^+e^- \rightarrow h_1\gamma )$$

σ
(

e
+

e
-

→

h
1

γ
)

can significantly be enhanced up to $$8.1\,\,\times 10^{-2}$$

8.1

×

10

-
2

fb, thus exceeding the Standard Model prediction. Additionally, as a byproduct, we also observed that $$R_{\gamma h_1}$$

R

γ

h
1

is entirely correlated with both the $$h_1\rightarrow \gamma \gamma $$

h
1

→
γ
γ

and $$h_1\rightarrow \gamma Z$$

h
1

→
γ
Z

signal strengths.
Critical infrastructure monitoring in CBRNe scenarios: a reliable and robust communication network for distributed multimodal sensors
Authors: Sporrer Sebastian , Niemann Norman , Hammer Christof 
Published: September 2024

AbstractThe malicious misuse of CBRNe agents can inflict extensive damage to critical infrastructure and terrorize public society. The effects of such attacks can range from financial or structural drawbacks to significant casualties. Recent terror attacks in Cucuta (2021) or Kabul (2021) demonstrate the need to protect infrastructures such as airports, power plants, and transportation infrastructure. In the face of these modern-day threats, the need for a reliable and effective monitoring system for critical infrastructure has become increasingly important. In a first contribution to the long-term development, we present an initial version of a concept that requires the implementation paradigm of diverse redundancy and secure communication using MQTTS relying on the included cipher suite. An initial set of node types is defined and assigned requirements for implementation. The software tools architecture we propose based on these requirements is designed to support network operators and developers by providing standard features for network management and sensor node implementation. This includes the definition of a secure semi-automatic onboarding process for new sensor nodes, which is presented in detail. We strive for independency from specific hardware platforms, software frameworks, and network technologies to enable an open standard for communication within a critical infrastructure sensor network and also between such networks in the future.
O lugar de enunciação de bebês em sofrimento psíquico e com desfechos distintos de linguagem aos dois anos
Authors: Hoogstraten Antônia Motta Roth van , Parlato-Oliveira Erika Maria , Souza Ana Paula Ramos de 
Published: September 2024

Este artigo analisa a singularidade linguística e psíquica de dois bebês com desfecho de linguagem distintos aos dois anos. Para análise utilizou-se a entrevista inicial e continuada, os Indicadores Clínicos de Referência/Risco ao Desenvolvimento Infantil (IRDI), os Sinais Enunciativos de Aquisição da Linguagem (SEAL), além de filmagens da interação entre mãe e bebê. Os resultados indicaram que apenas um dos casos houve superação do sofrimento psíquico e atraso na linguagem a partir do segundo ano de vida. Tanto o exercício das funções parentais quanto as condições dos bebês são fatores importantes em sua constituição psíquica e linguística, o que traz reflexões interdisciplinares importantes acerca da singularidade na relação entre esses dois aspectos do desenvolvimento infantil.
Qoheleth as a Realist
Authors: Dell Katharine J. 
Published: August 2024

Abstract
On a three stage “ladder,” from humanism to scepticism to pessimism, Ecclesiastes has traditionally been regarded as the last of those three. Many recent studies, however, have challenged this assessment, replacing humanism with optimism and presenting a stark choice between the two extremes of optimism and pessimism. In this paper it is argued that a middle way can be found, using the language of “realism.” How to define “a realist” and what this means for understanding Qoheleth is explored. Examples of Qoheleth’s pragmatic advice, experiential starting point, and continual balancing of life’s options are aired, and key indicators of his realism are found. These are demonstrated first, in his use and placement of the three major poems in the book, second, in his choice of phrases around “knowledge,” and third, in his use of exemplifying stories that ground his more abstract musings in a concrete reality.
Understanding the Role of  Exports and FDI in  Remittances-Growth Nexus  in Globalised India
Authors: Poonam  , Ravinder  , Saini Vijender Pal 
Published: September 2024

This current study aims to understand the role of exports and foreign direct investment (FDI) in remittances-growth nexus in globalised India for the period 1991–2022. The autoregressive distributed lag (ARDL) model is employed to test the co-integration among the variables. The long-run and short-run coefficients are estimated after confirmation of co-integration. The results confirm that in the long run, remittances show a negative and insignificant impact on India’s economic growth, while FDI and exports (EXP) have a positive and significant impact on economic growth. Whereas in the short run, remittances have no impact on economic growth, while FDI and inflation have a significant but negative impact on economic growth. Based on the findings, the authorities of the Indian economy are recommended to take appropriate policy steps to make necessary arrangements for increasing exports, attracting more FDI and controlling inflation. JEL Codes: F24, C22, J6, O47