bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lives of persons with disabilities in Cameroon after CRPD: voices of persons with disabilities in the Buea Municipality in Cameroon
Authors: Opoku Maxwell Peprah , Mprah Wisdom Kwadwo , Mckenzie Judith , Sakah Bernard Nsaidzedze , Badu Eric 
Published: May 2016

Abstract

Introduction:
The Convention on the Rights of Persons with Disabilities (CRPD) has been touted as a major breakthrough towards achieving equal rights for persons with disabilities. The promulgation of the convention provided clear guidelines for signatory countries to revise their legislation as well as to formulate policies that will take into consideration the needs of persons with disabilities. As Cameroon is a signatory to the convention, it is expected that disability-friendly policies have been implemented to enhance the living conditions of persons with disabilities. This study examined, from the perspectives of participants, the life experiences of persons with disabilities in the Buea Municipality 7 years after Cameroon signed the CRPD.

Methods:
The study adopted a qualitative method, involving focus-group discussions with 36 participants from three disability groups: hearing impaired, visually impaired, and physically impaired.

Findings:
The study found that persons with disabilities in the Buea Municipality faced many challenges in their daily endeavors. These challenges are a result of a lack of inclusive policies, leading to their exclusion from social and economic activities such as education, employment, and healthcare.

Conclusion:
Although the study is limited in scope, the findings suggest that persons with disabilities in the Buea Municipality were yet to benefit from the CRPD. It is, therefore, suggested that the government of Cameroon should formulate inclusive policies to address the numerous challenges facing persons with disabilities in the Buea Municipality.
Formalization of informally acquired competences as part of academic certificate programs in healthcare – “prototype” of a model / Formalisierung informell erworbener Kompetenzen im Rahmen akademischer Zertifikatsprogramme im Gesundheitsbereich – „Prototyp“ eines Modells
Authors: Wolf Alexander Karsten , Thiele Heike , Haar Markus , Kortekamp Stefanie , Braun von Reinersdorff Andrea 
Published: May 2016

AbstractThe health care sector is facing many aspects of transformation. One aspect amongst others herein is an alteration of qualification profiles. Universities have to focus on both aspects determining future qualification profiles and increasing permeability between educational systems in a sense of optimally intermeshing competences that have been acquired at universities and those that have been acquired outside of them. This leads to the question how to create university certificate programs that offers two aspects: academic qualification on the one hand and on the other hand a possibility to identify, evaluate and certify non-formally and informally acquired competences of participating students. The ultimate goal is to identify and evaluate a person´s overall competence in a clearly defined thematic context, whereat competences that have been acquired outside universities will play an important role. Competences that have been certified by these academic programs may be used later for crediting purposes. In this report an initial prototype is being presented. It defines itself mainly as additional novel way of discussing crediting concepts.
Raum und Macht – Eine Stoffgeschichte des Goldes im frühen 20. Jahrhundert
Authors: Grewe Bernd-Stefan 
Published: May 2016

Abstract
Focusing on the major flows of gold in early 20th century offers new perspectives on the various and often overlapping political, sociocultural and economic spaces that are linked to the production, transport, marketing and consumption of gold around the world. A material, but not materialistic, biography of gold helps to overcome the narrow “centrist” logic that still dominates many narratives of globalization as well as the historiography on gold. The paper studies different spatial impacts such as the geology and geographical conditions of the places where gold was found, the newly built infrastructures for energy and water with far-reaching effects, the political segregation of different ethnic groups, the systems of migrant work across national and imperial boundaries, work in mines on the surface and underground, channels of transport, the informal arrangements to direct the international flow of gold towards London, strategies of workers and unionists, the difficult conditions of peasant families in India as well as in South African reserves, and the important question of by whom and from where the global commodity chain of gold may have been directed.
Vom Rohstoff zum Produkt. Wirtschaftliche und technische Verflechtungen von Steinkohlen im Inde- und Wurmrevier
Authors: Thorade Nora 
Published: May 2016

Abstract
As an important fuel, hard coal shaped industrialisation. Due to its specific materiality, coal established different options for intertwining industry and resource. This paper concentrates on the one hand on the specific properties of coal and, on the other, on the economic and technological operations with coal. Using the example of the different material properties of coal from the coal districts of Inde and Wurm, these interrelations are examined and illustrate how a space of resource extraction could be arranged.
17-Hydroxyprogesterone responses to human chorionic gonadotropin are not associated with serum anti-Mullerian hormone levels among adolescent girls with polycystic ovary syndrome
Authors: Hou Jingwen , Cook-Andersen Heidi , Su H. Irene , Shayya Rana , Maas Kevin H. , Burt-Solorzano Christine M. , Kumar Ajay , Chang R. Jeffrey 
Published: May 2016

AbstractIn adult women with polycystic ovary syndrome (PCOS) 17-OHP responses to human chorionic gonadotropin (hCG) stimulation are highly variable and inversely correlated with serum anti-Mullerian hormone (AMH) levels. The objective of this study was to determine whether adolescents with PCOS exhibit similar variable 17-OHP responsiveness to hCG and whether these responses are correlated to AMH levels.In a prospective study, adolescent PCOS (n=14) and normal controls (n=10) received 25 μg of hCG, intravenously. Blood samples were obtained before and 24 h afterwards for measurement of 17-OHP and basal AMH.Variable 17-OHP responses to hCG were observed among PCOS girls similar to that observed in adults. There was no correlation between AMH and 17-OHP responses to hCG.Among adult and adolescent individuals with PCOS variable 17-OHP production appears to be characteristic of the disorder. In adolescent PCOS, 17-OHP responsiveness to hCG is not correlated to AMH.
A fixed point approach to the Mittag-Leffler-Hyers-Ulam stability of a fractional integral equation
Authors: Eghbali Nasrin , Kalvandi Vida , Rassias John M. 
Published: May 2016

Abstract
In this paper, we have presented and studied two types of the Mittag-Leffler-Hyers-Ulam stability of a fractional integral equation. We prove that the fractional order delay integral equation is Mittag-Leffler-Hyers-Ulam stable on a compact interval with respect to the Chebyshev and Bielecki norms by two notions.
‘Blood as the Seat of Life’: The Blood Paradox among Afro-Christians
Authors: Machingura Francis , Museka Godfrey 
Published: May 2016

Abstract
The study is a response to the call for papers on African issues and it focuses on the theme of blood. The chapter seeks to answer the following questions: Why is blood, the sanctity of life, associated with defilement? How can the good and purity of life which blood symbolizes come out of impurities? How is the practice of blood manipulation represented in biblical texts? How can bodily refuse in this case blood be conceived as a symbol of purity, power and danger? How do readers of biblical texts understand the textual representations and interpretations of blood? Does each mode of blood manipulation rituals function as communicative symbols? Our response to these questions is threefold. First, we consider the sanctity of blood in relation to its purity and power. This is followed by an examination of danger beliefs associated with blood and lastly by an analysis of the sacred/taboo or purity/danger dichotomy within the context of the Old Testament and the New Testament as well as of the Shona Afro-Christians.
Religio-Culture, Fear, and Zimbabwe’s Leadership Perceptions
Authors: Bhebhe Muchumayeli 
Published: May 2016

Abstract
The study is a response to the call for papers on African issues and discusses the notion of leadership in the Zimbabwean context. Based on material drawn through an interdisciplinary research process, this article argues that the phenomenon of fear emanating from a Zimbabwean religio-culture cuts across the country’s socio-political structures and affects its different forms of leadership. Therefore, by drawing on primary and secondary as well as literary and non-literary, sources, the article examines how and why religio-culture and especially its elements, such as the phenomenon of fear, continue to influence the people’s understanding of leadership. The quest for a cross-cultural perspective leads to the consideration of both African and non-African scholarly views. In order to draw on concrete data, I focus on the perceptions and experiences of ordinary citizens whether professionals or non-professionals. Furthermore, the study considers arguments and propositions from disciplines such as history, political science, religious studies, anthropology, and African philosophy, among others.
Rethinking Christian Identity: African Reflections from Pauline Writings
Authors: Togarasei Lovemore 
Published: May 2016

Abstract
Despite its existence for over a century in Africa and statistics putting the Christian populations at average 80 percent mostly in sub-Saharan African countries, Christianity has not managed to provide an alternative identity to ethnicity as issues of identity continue dogging the continent. Many African societies remain divided and at war on the basis of identities, be they racial, tribal, creedal, gender, class, language or other identities. Surprisingly, this state of affairs is also found even within the precincts of the church. Many churches remain divided along racial, ethnic, tribal, and other identities. One does not need to look far and wide to acknowledge this reality. Does Christianity have an identity? Could the writings of Paul address the issues of Christian identity? Or do the writings address this problem at all? These are the questions at the heart of this paper. Making use of Pauline texts such as Galatians 3:28 and scholarly works such as those of Buell and Hodge (2004:237), I discuss Paul’s understanding of Christian identity and its implications for Christian identity in Africa today.
The Costs of Implementing a Unilateral One-Sided Exchange Rate Target Zone
Authors: Hertrich Markus 
Published: May 2016

Abstract
In the aftermath of the recent financial crisis, the central banks of small open economies such as the Swiss National Bank (SNB) implemented a unilateral one-sided exchange rate target zone vis-à-vis the euro currency to counteract deflationary pressures. Recently, the SNB abandoned its minimum exchange rate regime, arguing that after having analyzed the costs and benefits of this non-standard exchange rate policy measure, it was no longer sustainable. This paper proposes a model that allows central banks and policymakers to estimate ex-ante the costs of implementing and maintaining a unilateral one-sided target zone (in terms of the expected size of foreign-exchange interventions) and to monitor these costs during the period in which it is enforced. The model also offers central banks a tool to identify the right timing for the discontinuation of a minimum exchange rate regime. An empirical application to the Swiss case shows the ex-ante estimated size of these costs and reveals that these costs might have been substantial without the abandonment of the minimum exchange rate regime, which accords with the official statements of the SNB.
Growth in European Crisis Countries: Cyclical Normality or the Result of Structural Reforms?
Authors: Hielscher Kai 
Published: May 2016

Abstract
In mid-2013 the macroeconomic situation in European crisis economies started to show signs of recovery. In the political debate, improving economic conditions were often attributed to recently enacted structural reforms. In this paper, we use empirical business cycle models to indirectly assess the short term impact of recent structural reforms on growth. Given the past deep recession, a typical cyclical movement would imply far higher growth rates than have been observed in such countries in the recent recovery. Short-term economic performance is rather a sign of a long-lasting and severe weakness in demand which can almost exclusively be explained by characteristics of business cycles following financial crises as well as the initial situation in European crisis economies prior to 2009. With different approaches we are not able to deliver evidence that structural reforms have yet had a significant impact on growth, neither a positive nor a negative one. It will still take time for growth effects to materialize.
Sparse factor model for co-expression networks with an application using prior biological knowledge
Authors: Blum Yuna , Houée-Bigot Magalie , Causeur David 
Published: May 2016

Abstract
Inference on gene regulatory networks from high-throughput expression data turns out to be one of the main current challenges in systems biology. Such networks can be very insightful for the deep understanding of interactions between genes. Because genes-gene interactions is often viewed as joint contributions to known biological mechanisms, inference on the dependence among gene expressions is expected to be consistent to some extent with the functional characterization of genes which can be derived from ontologies (GO, KEGG, …). The present paper introduces a sparse factor model as a general framework either to account for a prior knowledge on joint contributions of modules of genes to latent biological processes or to infer on the corresponding co-expression network. We propose an ℓ
1 – regularized EM algorithm to fit a sparse factor model for correlation. We demonstrate how it helps extracting modules of genes and more generally improves the gene clustering performance. The method is compared to alternative estimation procedures for sparse factor models of relevance networks in a simulation study. The integration of a biological knowledge based on the gene ontology (GO) is also illustrated on a liver expression data generated to understand adiposity variability in chicken.
Synthesis and characterisation of long wavelength-absorbing donor/acceptor-substituted methine dyes
Authors: Heichert Christoph , Hartmann Horst 
Published: May 2016

AbstractBy the reaction of aromatic or heteroaromatic formyl compounds or their corresponding iminium salts with active methylene compounds a series of new methine dyes with long-wavelength absorption in the near-infrared spectral range were prepared.
Sir2/Sirt1 Links Acute Inebriation to Presynaptic Changes and the Development of Alcohol Tolerance, Preference, and Reward
Authors: Engel Gregory L. , Marella Sunanda , Kaun Karla R. , Wu Julia , Adhikari Pratik , Kong Eric C. , Wolf Fred W. 
Published: May 2016

Acute ethanol inebriation causes neuroadaptive changes in behavior that favor increased intake. Ethanol-induced alterations in gene expression, through epigenetic and other means, are likely to change cellular and neural circuit function. Ethanol markedly changes histone acetylation, and the sirtuin Sir2/SIRT1 that deacetylates histones and transcription factors is essential for the rewarding effects of long-term drug use. The molecular transformations leading from short-term to long-term ethanol responses mostly remain to be discovered. We find that Sir2 in the mushroom bodies of the fruit flyDrosophilapromotes short-term ethanol-induced behavioral plasticity by allowing changes in the expression of presynaptic molecules. Acute inebriation strongly reduces Sir2 levels and increases histone H3 acetylation in the brain. Flies lacking Sir2 globally, in the adult nervous system, or specifically in the mushroom body α/β-lobes show reduced ethanol sensitivity and tolerance. Sir2-dependent ethanol reward is also localized to the mushroom bodies, and Sir2 mutants prefer ethanol even without a priming ethanol pre-exposure. Transcriptomic analysis reveals that specific presynaptic molecules, including the synaptic vesicle pool regulator Synapsin, depend on Sir2 to be regulated by ethanol. Synapsin is required for ethanol sensitivity and tolerance. We propose that the regulation of Sir2/SIRT1 by acute inebriation forms part of a transcriptional program in mushroom body neurons to alter presynaptic properties and neural responses to favor the development of ethanol tolerance, preference, and reward.SIGNIFICANCE STATEMENTWe identify a mechanism by which acute ethanol inebriation leads to changes in nervous system function that may be an important basis for increasing ethanol intake and addiction liability. The findings are significant because they identify ethanol-driven transcriptional events that target presynaptic properties and direct behavioral plasticity. They also demonstrate that multiple forms of ethanol behavioral plasticity that are relevant to alcoholism are initiated by a shared mechanism. Finally, they link these events to theDrosophilabrain region that associates context with innate approach and avoidance responses to code for reward and other higher-order behavior, similar in aspects to the role of the vertebrate mesolimbic system.
Chronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency
Authors: Koranda Jessica L. , Krok Anne C. , Xu Jian , Contractor Anis , McGehee Daniel S. , Beeler Jeff A. , Zhuang Xiaoxi 
Published: May 2016

Although dopamine receptor antagonism has long been associated with impairments in motor performance, more recent studies have shown that dopamine D2 receptor (D2R) antagonism, paired with a motor task, not only impairs motor performance concomitant with the pharmacodynamics of the drug, but also impairs future motor performance once antagonism has been relieved. We have termed this phenomenon “aberrant motor learning” and have suggested that it may contribute to motor symptoms in movement disorders such as Parkinson's disease (PD). Here, we show that chronic nicotine (cNIC), but not acute nicotine, treatment mitigates the acquisition of D2R-antagonist-induced aberrant motor learning in mice. Although cNIC mitigates D2R-mediated aberrant motor learning, cNIC has no effect on D1R-mediated motor learning. β2-containing nicotinic receptors in dopamine neurons likely mediate the protective effect of cNIC against aberrant motor learning, because selective deletion of β2 nicotinic subunits in dopamine neurons reduced D2R-mediated aberrant motor learning. Finally, both cNIC treatment and β2 subunit deletion blunted postsynaptic responses to D2R antagonism. These results suggest that a chronic decrease in function or a downregulation of β2-containing nicotinic receptors protects the striatal network against aberrant plasticity and aberrant motor learning induced by motor experience under dopamine deficiency.SIGNIFICANCE STATEMENTIncreasingly, aberrant plasticity and aberrant learning are recognized as contributing to the development and progression of movement disorders. Here, we show that chronic nicotine (cNIC) treatment or specific deletion of β2 nicotinic receptor subunits in dopamine neurons mitigates aberrant motor learning induced by dopamine D2 receptor (D2R) blockade in mice. Moreover, both manipulations also reduced striatal dopamine release and blunt postsynaptic responses to D2R antagonists. These results suggest that chronic downregulation of function and/or receptor expression of β2-containing nicotinic receptors alters presynaptic and postsynaptic striatal signaling to protect against aberrant motor learning. Moreover, these results suggest that cNIC treatment may alleviate motor symptoms and/or delay the deterioration of motor function in movement disorders by blocking aberrant motor learning.
Conscious Vision Proceeds from Global to Local Content in Goal-Directed Tasks and Spontaneous Vision
Authors: Campana Florence , Rebollo Ignacio , Urai Anne , Wyart Valentin , Tallon-Baudry Catherine 
Published: May 2016

The reverse hierarchy theory (Hochstein and Ahissar, 2002) makes strong, but so far untested, predictions on conscious vision. In this theory, local details encoded in lower-order visual areas are unconsciously processed before being automatically and rapidly combined into global information in higher-order visual areas, where conscious percepts emerge. Contingent on current goals, local details can afterward be consciously retrieved. This model therefore predicts that (1) global information is perceived faster than local details, (2) global information is computed regardless of task demands during early visual processing, and (3) spontaneous vision is dominated by global percepts. We designed novel textured stimuli that are, as opposed to the classic Navon's letters, truly hierarchical (i.e., where global information is solely defined by local information but where local and global orientations can still be manipulated separately). In line with the predictions, observers were systematically faster reporting global than local properties of those stimuli. Second, global information could be decoded from magneto-encephalographic data during early visual processing regardless of task demands. Last, spontaneous subjective reports were dominated by global information and the frequency and speed of spontaneous global perception correlated with the accuracy and speed in the global task. No such correlation was observed for local information. We therefore show that information at different levels of the visual hierarchy is not equally likely to become conscious; rather, conscious percepts emerge preferentially at a global level. We further show that spontaneous reports can be reliable and are tightly linked to objective performance at the global level.SIGNIFICANCE STATEMENTIs information encoded at different levels of the visual system (local details in low-level areas vs global shapes in high-level areas) equally likely to become conscious? We designed new hierarchical stimuli and provide the first empirical evidence based on behavioral and MEG data that global information encoded at high levels of the visual hierarchy dominates perception. This result held both in the presence and in the absence of task demands. The preferential emergence of percepts at high levels can account for two properties of conscious vision, namely, the dominance of global percepts and the feeling of visual richness reported independently of the perception of local details.