bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous achieving color‐tuning long persistent luminescence and phosphorescent quantum yield of 81.05% in 2D organic metal halide perovskite
Authors: Wang Zheng , Li Chen‐Qi , Mo Jun‐Ting , Pan Mei 
Published: October 2024

AbstractIonically bonded organic metal halide perovskite‐like luminescent materials, which incorporate organic cations and metal halides, have emerged as a versatile multicomponent material system. However, these materials still face challenges in terms of low phosphorescence quantum yields and limited long persistent luminescence (LPL) colors. Herein, we present the design and synthesis of an intraligand charge‐transfer organic‐based metal halide perovskite‐like material, in which organic cations form a compact supramolecular hydrogen‐bonded organic framework (HOF) structure, exhibiting crystallization‐induced phosphorescence emission of ligand, while metal halides form a unique two‐dimensional (2D) structure that displays intrinsic self‐trapped excitons (STE) emission under the radiation of UV light. Notably, the metal halide hybrid is found to exhibit enhanced phosphorescent photoluminescence efficiency of up to 81.05% and tunable LPL from cyan to orange compared to the pristine organic phosphor, due to the structural distortion and scaffolding effects of 2D metal halides as well as a well‐packed HOF structure. Optical characterizations and theoretical calculations reveal that charge transfer from organic cations and halogen to ligand as well as STE from inorganic layers are responsible for the tunable LPL. Meanwhile, the high‐efficiency phosphorescent quantum yield is attributed to stronger hydrogen bond stacking as well as structural distortion of metal halogen bands. Thus, the obtained LPL provides potentials in anti‐counterfeiting, security systems, and so on.
Where did they come from, where did they go? Niche conservatism in woody and herbaceous plants and implications for plant‐based paleoclimatic reconstructions
Authors: Quirk Zack J. , Smith Selena Y. , Paul Acosta R. , Poulsen Christopher J. 
Published: October 2024

AbstractPremiseThe ecological conditions that constrain plants to an environmental niche are assumed to be constant through time. While the fossil record has been used previously to test for niche conservatism of woody flowering plants, additional studies are needed in other plant groups especially since they can provide insight with paleoclimatic reconstructions, high biodiversity in modern terrestrial ecosystems, and significant contributions to agriculture.MethodsWe tested climatic niche conservatism across time by characterizing the climatic niches of living herbaceous ginger plants (Zingiberaceae) and woody dawn redwood (Metasequoia) against paleoniches reconstructed based on fossil distribution data and paleoclimatic models.ResultsDespite few fossil Zingiberaceae occurrences in the latitudinal tropics, unlike living Zingiberaceae, extinct Zingiberaceae likely experienced paratropical conditions in the higher latitudes, especially in the Cretaceous and Paleogene. The living and fossil distributions of Metasequoia largely remain in the upper latitudes of the northern hemisphere. The Zingiberaceae shifted from an initial subtropical climatic paleoniche in the Cretaceous, toward a temperate regime in the late Cenozoic; Metasequoia occupied a more consistent climatic niche over the same time intervals.ConclusionsBecause of the inconsistent climatic niches of Zingiberaceae over geologic time, we are less confident of using them for taxonomic‐based paleoclimatic reconstruction methods like nearest living relative, which assume a consistent climatic niche between extant and extinct relatives; we argue that the consistent climatic niche of Metasequoia is more appropriate for these reconstructions. Niche conservatism cannot be assumed between extant and extinct plants and should be tested further in groups used for paleoclimatic reconstructions.
Functional disabilities and adverse well‐being by COVID‐19 and Long COVID history and employment status: 2022 Behavioral Risk Factor Surveillance System
Authors: Silver Sharon R. , Li Jia , Ford Nicole D. , Saydah Sharon H. 
Published: October 2024

AbstractBackgroundLong COVID can lead to functional disabilities and decreased well‐being and limit the ability to work. No study has yet assessed associations of SARS‐CoV‐2‐infection and Long COVID with specific measures of well‐being and functional disabilities among workers by employment status.MethodsUsing data from the U.S. Behavioral Risk Factor Surveillance System, we assessed the prevalence of functional disabilities and well‐being measures among adults of prime working age (25–54 years) by employment status and self‐reported COVID‐19 and Long COVID history. Within each employment status, we generated adjusted prevalence ratios (aPRs) comparing respondents from each 2022 COVID‐19/Long COVID category to respondents in that employment status before the pandemic (2019).ResultsIn 2022, prevalences of each functional disability except vision and all adverse well‐being measures were highest among the 9.2% of respondents reporting a history of Long COVID. For each outcome, prevalences were lowest for workers and highest among those unable to work. 2022 prevalence of cognitive disability (16.4% of employees, 21.4% of the self‐employed) and depression (31.2% and 36.4%, respectively) among workers reporting a history of Long COVID were more than double 2019 levels. Increases in cognitive disability and depression were lower but statistically significant among workers not reporting a history of Long COVID.ConclusionsThe high prevalence of functional disabilities and adverse well‐being among workers reporting a history of Long COVID have implications for workers and employers. Also concerning are smaller increases among workers not reporting a history of Long COVID, given the large number of affected workers. Mitigating the effects of Long COVID on workers will involve efforts in multiple domains: reducing incidence, increasing healthcare practitioner awareness, improving diagnosis and treatments, and increasing employer awareness of best practices for accommodating workers with Long COVID.
Synaptic and extrasynaptic distribution of NMDA receptors in the cortex of Alzheimer's disease patients
Authors: Escamilla Sergio , Badillos Raquel , Comella Joan X. , Solé Montse , Pérez‐Otaño Isabel , Mut Jose V. Sánchez , Sáez‐Valero Javier , Cuchillo‐Ibáñez Inmaculada 
Published: October 2024

AbstractBACKGROUNDSynaptic and extrasynaptic distribution of N‐methyl‐D‐aspartate receptors (NMDARs) has not been addressed in the brain from Alzheimer´s disease (AD) subjects, despite their contribution to neurodegeneration.METHODSWe have developed a protocol to isolate synaptic and extrasynaptic membranes from controls and AD frontal cortex. We characterized the distribution of the NMDAR subunits GluN2B, GluN2A, GluN1, and GluN3A, as well as post‐translational modifications, such as phosphorylation and glycosylation.RESULTSLower levels of synaptic GluN2B and GluN2A were found in AD fractions, while extrasynaptic GluN2B and GluN1 levels were significantly higher; GluN3A distribution remained unaffected in AD. We also identified different glycoforms of GluN2B and GluN2A in extrasynaptic membranes. Synaptic Tyr1472 GluN2B phosphorylation was significantly lower in AD fractions.DISCUSSIONReduction of synaptic NMDAR subunits, particularly for GluN2B, is likely to contribute to synaptic transmission failure in AD. Additionally, the increment of extrasynaptic NMDAR subunits could favor the activation of excitotoxicity in AD.Highlights
New protocol to isolate synaptic and extrasynaptic membranes from the human cortex.
Low GluN2B and GluN2A levels in Alzheimer´s disease (AD) synaptic membranes.
High GluN2B and GluN1 levels in AD extrasynaptic membranes.
Specific glycoforms of extrasynaptic GluN2B and GluN2A.
Low phosphorylation at Tyr1472 in synaptic GluN2B in AD.
Stable and Recyclable Copper Nanoclusters with Exposed Active Sites for Broad‐Scope Protosilylation in Open Air
Authors: Wen Songwei , Zhang Chengkai , Liu Li‐Juan , Wang Zhi , Sun Di , He Jian 
Published: October 2024

AbstractDespite recent advances in cluster‐based catalysis for organic synthesis, the substrate scope of reactions catalyzed by metal nanoclusters is typically not superior to previously established catalytic systems. Herein, we develop new atomically precise copper nanoclusters for protosilylation, with scope expanding to alkenes and simple enynes that were not suitable for prior synthetic methodologies with traditional copper complexes. The involvement of a second copper center in the metal kernel during the migratory insertion step is thought to be responsible for the expanded scope. In addition, the reaction is highly compatible with water and can be carried out in open air rather than under inert gas protection. Mechanistic studies suggest that the cluster‐catalyzed protosilylation proceeds in the absence of silyl radicals. The current findings demonstrate the potential of using metal nanoclusters for practical and sustainable chemical synthesis.
Novel Inorganic‐Organic Dual‐Photosensitizing Dinuclear‐Metal Self‐Assembly System for Efficient Artificial Photosynthesis without Sacrificial Electron Donors
Authors: Wang Jiaxin , Song Tianqun , Liu Zheyuan , Yun Qinbai , Sun Juehan , Zhang Ying , Yuan Kuo , Zhong Dichang , Tang Zhiyong , Lu Tongbu 
Published: October 2024

AbstractOwing to the unique synergistic effect, dinuclear‐metal‐molecule‐catalysts (DMCs) show excellent performance in catalytic fields. However, for overall photocatalytic CO2 reaction (CO2RR), it is still a challenge to construct well‐matched photosensitizer (PS) components for DMCs‐based photocatalysts. Inorganic‐quantum‐dot PS possesses capacities of multiple exciton generation and catalyzing water oxidation but is incompatible with DMCs. In contrast, organic PS can be covalently linked with DMCs but inescapable of using sacrificial electron donors. For overall photocatalytic CO2RR, organic–inorganic dual‐photosensitizing system might be a promising candidate. Herein, we employed covalent‐linking and electrostatic‐driven approaches to construct the self‐assembly of pyrene‐sensitized Co2L DMCs (Py‐Co2L) and perovskite (PVK) quantum dots, i.e., PVK@[Py‐Co2L]. Using H2O as an electron donor, PVK@[Py‐Co2L] realized 105.24 μmol ⋅ g−1⋅h−1 CO yield in photocatalytic CO2RR, much higher than PVK (15.44 μmol ⋅ g−1⋅h−1) and PVK@Co2L (32.30 μmol ⋅ g−1 ⋅ h−1), ascribing to the efficient photogenerated charge separation and transfer. The experimental results and theoretical investigations demonstrated that the pyrene linked on Co2L boosted the electron delivery from PVK to DMCs. Besides, this strategy could also be extended to the photocatalytic H2 evolution coupled with alcohol oxidation. As a proof‐of‐concept, our work lightens the integration of DMCs, organic and inorganic PS components, promoting the development of photocatalysis without sacrificial electron donors.
Engineering a Cu‐Pd Paddle‐Wheel Metal–Organic Framework for Selective CO2 Electroreduction
Authors: Zhang Ruirui , Liu Yan , Ding Pan , Huang Juanjuan , Dierolf Martin , Kelly Shelly D. , Qiu Xinqi , Chen Yishuo , Hussain Mian Zahid , Li Weijin , Bunzen Hana , Achterhold Klaus , Pfeiffer Franz , Sharp Ian D. , Warnan Julien , Fischer Roland A. 
Published: October 2024

AbstractOptimizing the binding energy between the intermediate and the active site is a key factor for tuning catalytic product selectivity and activity in the electrochemical carbon dioxide reduction reaction. Copper active sites are known to reduce CO2 to hydrocarbons and oxygenates, but suffer from poor product selectivity due to the moderate binding energies of several of the reaction intermediates. Here, we report an ion exchange strategy to construct Cu−Pd paddle wheel dimers within Cu‐based metal–organic frameworks (MOFs), [Cu3‐xPdx(BTC)2] (BTC=benzentricarboxylate), without altering the overall MOF structural properties. Compared to the pristine Cu MOF ([Cu3(BTC)2], HKUST‐1), the Cu−Pd MOF shifts CO2 electroreduction products from diverse chemical species to selective CO generation. In situ X‐ray absorption fine structure analysis of the catalyst oxidation state and local geometry, combined with theoretical calculations, reveal that the incorporation of Pd within the Cu−Pd paddle wheel node structure of the MOF promotes adsorption of the key intermediate COOH* at the Cu site. This permits CO‐selective catalytic mechanisms and thus advances our understanding of the interplay between structure and activity toward electrochemical CO2 reduction using molecular catalysts.
Atomically Asymmetrical Ir−O–Co Sites Enable Efficient Chloride‐Mediated Ethylene Electrooxidation in Neutral Seawater
Authors: Cai Linke , Liu Yao , Gao Ying , Zhao Bo‐Hang , Guan Jiacheng , Liu Xiao , Zhang Bin , Huang Yi 
Published: October 2024

AbstractThe chloride‐mediated ethylene oxidation reaction (EOR) of ethylene chlorohydrin (ECH) via electrocatalysis is practically attractive because of its sustainability and mild reaction conditions. However, the chlorine oxidation reaction (COR), which is essential for the above process, is commonly catalyzed by dimensionally stable anodes (DSAs) with high contents of precious Ru and/or Ir. The development of highly efficient COR electrocatalysts composed of nonprecious metals or decreased amounts of precious metals is highly desirable. Herein, we report a modified Co3O4 with a single‐atom Ir substitution (Ir1/Co3O4) as a highly efficient COR electrocatalyst for chloride‐mediated EOR to ECH in neutral seawater. Ir1/Co3O4 achieves a Faradaic efficiency (FE) of up to 94.8 % for ECH generation and remarkable stability. Combining experimental results and density functional theory (DFT) calculations, the unique atomically asymmetrical Ir−O−Co configuration with a strong electron coupling effect in Ir1/Co3O4 can accelerate electron transfer to increase the reaction kinetics and maintain the structural stability of Co3O4 during COR. Moreover, a coupling reaction system integrating the anodic chloride‐mediated and cathodic H2O2‐mediated EOR show a total FE of ~170 % for paired electrosynthesis of ECH and ethylene glycol (EG) using ethylene as the raw material. The technoeconomic analysis highlights the promising application prospects of this system.
Oligonucleotide therapeutics in sports? An antidoping perspective
Authors: Parr Maria K. , Keiler Annekathrin M. 
Published: October 2024

AbstractWithin the last two decades, the European Medicines Agency and the US Food and Drug Administration have approved several gene therapies. One category is oligonucleotide therapeutics, which allow for the regulation of the expression of target genes. Besides already approved therapeutics, there are several preclinical and clinical trials ongoing. The World Anti‐Doping Agency prohibits the use of “nucleic acids or nucleic acid analogs that may alter genome sequences and/or alter gene expression by any mechanism” as a nonspecified method at all times. Hence, the administration of nucleic acids or analogs by athletes would cause an Anti‐Doping Rule Violation. Herein, we discuss types of oligonucleotide therapeutics, their potential to be misused in sports, and considerations to sample preparation and mass spectrometric approaches with regard to antidoping analysis.
Beyond one size fits all: Probing patient choices in gestational diabetes management, from screening to postpartum
Authors: Mobin Ayman , Obeid Amir , El‐Kebbi Imad , Everett Dean , Ibrahim Saleh , Farhat Joviana , Al‐Omari Basem 
Published: October 2024

AbstractDuring antenatal care, gestational diabetes mellitus (GDM) screening is crucial for early diagnosis and treatment to ameliorate clinical outcomes and limit health care expenses. Dietary management and physical activity are central to GDM treatment, however, adherence is often influenced by personal preferences, socioeconomic barriers, and psychological stress. Pharmacologically, insulin and oral hypoglycemic medications, are the main GDM treatment that can be subject to patients' resistance due to fears of needles and side effects. Metformin is increasingly preferred for its ease of administration and lower cost. In the postpartum stage, regular screening for type 2 diabetes mellitus (T2DM) should always be considered despite the possible limitations that could arise, including communication gaps, lack of long‐term focus, and personal barriers. Overall, women with GDM prefer personalized, flexible management plans that consider their lifestyle, support from health care professionals (HCPs), and family involvement. Addressing psychological and socioeconomic barriers through education, counseling, and support networks is crucial for improving adherence and health outcomes. Enhancing patient‐centered care and shared decision‐making can empower women with GDM to manage their condition effectively and maintain lifestyle changes postpartum. Therefore, this review aimed to assess pregnant women's preferences in GDM management, focusing on screening, dietary recommendations, physical activity, and treatment. Additionally, this review examined GDM care in terms of these patients' quality of life and postpartum experiences.
On the Properties of PLS for Analyzing Two‐Level Factorial Experimental Designs
Authors: Borràs‐Ferrís Joan , Folch‐Fortuny Abel , Ferrer Alberto 
Published: October 2024

ABSTRACTWe present here a novel methodology to analyze data from two‐level factorial experimental designs, with or without missing runs, with just one method: partial least squares regression with one response variable (PLS1, hereinafter PLS). This property is very attractive for practitioners because, to the best of our knowledge, no other statistical tool has comparable versatility. In the case of a full and fractional factorial design, the one‐PLS component model yields the same analytical solution as multiple linear regression (MLR), not only in the estimation of the effects but also in their statistical significance. When having missing runs in the factorial design, PLS is of particular interest as it is a powerful tool when dealing with complex correlation structures, as opposed to MLR. Thus, we challenge the widely held view that PLS is useful only when dealing with nonexperimental design (i.e., correlated observational data). The methodology is illustrated by two illustrative examples and synthesized by an easy‐to‐follow route map useful for practitioners.
Enrichment Strategies for Low‐Abundant Single Nucleotide Mutations
Authors: Guo Chen , Ding Ruolin , Zhao Zhihe , Guo Jian , Li Feng 
Published: October 2024

AbstractOver the past three decades, significant advancements have been made in mutation enrichment methods, driven by the increasing need for precise and efficient identification of rare genetic variants associated with diseases. Mutation‐enrichment methods have emerged to boost sensitivity and enable easy detection of low‐frequency mutations. These methods are crucial in genomics research and clinical diagnostics, allowing for the detection of low‐frequency mutations within large genomic datasets. This review presents a summary of technological developments in rare mutation enrichment and emphasizes their mechanisms and applications in liquid biopsies.
Chiroptical Sensing of Amines With Isatins
Authors: Kariapper F. Safia , Miccolis Flavia , Pilicer Samantha L. , Wolf Christian 
Published: October 2024

ABSTRACTIsatins are extensively researched compounds with diverse applications, particularly as synthetic precursors in pharmaceutical developments. However, their use as optical probes for enantioselective sensing of chiral amines has not been explored to date. Herein, we present a novel chiroptical assay with an optimized isatin that generates strong, red‐shifted circular dichroism (CD) signals at approximately 380 nm upon ketimine formation with chiral amines. The intensity of the induced CD signal increases linearly with the enantiomeric excess of the analyte and thus allows quantitative chirality analysis. The general usefulness of this approach is demonstrated with a broad range of aliphatic and aromatic chiral amines, and by accurate determination of the enantiomeric composition of 10 samples.
Mechanism of TMB Discoloration Catalyzed by Layered CoNi@CN Nanozymes: Application Based on Smart Phone for Resorcinol Detection
Authors: Guo Qingyong , Xiao Rongsheng , Chen Haifeng , Bao Meishuo , Qi Jingwen , Jia Qian‐qian , Zhang Wuxiang 
Published: October 2024

Comprehensive SummaryReal‐time on‐site monitoring of resorcinol (RS) concentrations is crucial for detecting hazardous levels, enabling prompt response measures to mitigate potential environmental and health risks. In this study, we developed an innovative method using CoNi@CN‐2 nanozymes to activate peroxymonosulfate (PMS) for oxidizing 3,3',5,5'‐tetramethylbenzidine (TMB). Our results show that the formation of Ni2+ through the oxidation of Ni0 on the CoNi@CN‐2 surface significantly enhances the electron‐donating capacity of Co0. The catalytic reaction of TMB is mediated by redox active species (SO4•−, •O2−, •OH and 1O2). RS drives colorimetry by transferring electrons to the benzene ring and specific nitrogen atoms in ox‐TMB, reducing ox‐TMB to TMB. Furthermore, the colorimetric assay shows a robust linear correlation between RS concentration and absorbance (Abs), described by Abs = –0.44[RS] + 0.886 (0—200 μmol/L, R2 = 0.983). Also, we introduce a novel smartphone‐integrated autonomous detection software that can analyze RS concentration and grayscale values (GSV), yielding GSV = 0.327[RS] + 63.601 (0—200 μmol/L, R2 = 0.990) with a detection limit of 5.29 μmol/L. Additionally, excess PMS leads to ROS attacking specific sites in ox‐TMB, forming secondary oxidation products. This study has enabled rapid and accurate detection of RS, making a significant contribution to environmental safety and protection.
Bushy‐Tailed Multicationic Quaternary Phosphonium Compounds: Potent Amphiphilic Disinfectants with Promising Therapeutic Indices
Authors: Rachii Diana , Bezold Elise L. , Wuest William M. , Minbiole Kevin P. C. 
Published: October 2024

AbstractQuaternary ammonium compounds (QACs) have been essential for protecting human health for almost a century, functioning as surface disinfectants and sanitizers. With bacterial resistance increasing against commercially available QACs, the development of novel antimicrobials with divergent architectures is essential for effective infection prevention and control. Toward this end, our group has expanded beyond traditional ammonium scaffolds and explored the development of quaternary phosphonium compounds (QPCs). Herein, we report the synthesis and biological investigation of a series of 20 novel multicationic QPCs, bearing multiple short alkyl or aryl chains, also referred to as “bushy‐tailed” multiQPCs; these structures were hypothesized to have strong bioactivity while displaying low mammalian toxicity. Select bushy‐tailed QPC derivatives with trishexylphosphonium groups displayed single‐digit or sub‐micromolar activity against all seven bacteria tested, and MIC values of 2‐ to 8‐fold better than their bushy‐tailed QAC counterparts. Importantly, therapeutic indices of these bushy‐tailed QPCs were favorable in many cases, and were ≥4 against the entire bacterial panel for pX‐P6*,P6* and 1,8‐P6*,P6*, superior to more traditional architectures. This work highlights the promise of a novel set of multicationic phosphonium compounds as novel disinfectants with potent bioactivities and low toxicity.