bluuebunny/crossref_metadata_2025_split huggingface dataset:
Popularity estimation of interesting locations from visitor’s
trajectories using fuzzy inference system
Authors: Tiwari Shivendra , Kaushik Saroj 
Published: February 2016

Abstract
Identifying the interesting places through GPS
trajectory mining has been well studied based on the visitor’s
frequency. However, the places popularity estimation
based on the trajectory analysis has not been explored yet.
The limitation in the majority of the traditional popularity
estimation and place user-rating based methods is that all
the participants are given the same importance. In reality,
it heavily depends on the visitor’s category, for example,
international visitors make distinct impact on popularity.
The proposed method maintains a registry to keep the information
about the visited users, their stay time and the
travel distance from their home location. Depending on
the travel nature the visitors are labeled as native, regional
and tourist for each place in question. It considers the fact
that the higher stay in a place is an implicit measure of the
greater likings. Theweighted frequency is eventually fuzzified and applied rule based fuzzy inference system (FIS) to
compute popularity of the places in terms of the ratings
∈ [0, 5]. We have evaluated the proposed method using a
large real road GPS trajectory of 182 users for identifying
the ratings for the collected 26807 point of interests (POI)
in Beijing (China).
A Biconvex Form for Copulas
Authors: Fuchs Sebastian 
Published: February 2016

Abstract
We study the integration of a copula with respect to the probability measure generated by another
copula. To this end, we consider the map [. , .] : C × C → R given by

where C denotes the collection of all d–dimensional copulas and QD denotes the probability measures associated
with the copula D. Specifically, this is of interest since several measures of concordance such as
Kendall’s tau, Spearman’s rho and Gini’s gamma can be expressed in terms of the map [. , .]. Quite generally,
the map [. , .] can be applied to construct and investigate measures of concordance.
Fact-Checking Polarized Politics: Does The Fact-Check Industry Provide Consistent Guidance on Disputed Realities?
Authors: Marietta Morgan , Barker David C. , Bowser Todd 
Published: February 2016

AbstractIn the contemporary political environment of polarized claims about disputed realities, the online fact-check industry was born. These enterprises have received awards and praise but also accusations of bias and error, bringing their methods and conclusions into question. This paper examines the comparative epistemology of the three major fact-check sites: do they examine the same questions and reach the same conclusions? A content analysis of the published fact-checks addressing three disputed realties – the existence of climate change, the influence of racism, and the consequences of the national debt – suggests substantial differences in the questions asked and the answers offered, limiting the usefulness of fact-checking for citizens trying to decide which version of disputed realities to believe.
Nuclear Fallout: Investigating the Effect of Senate Procedural Reform on Judicial Nominations
Authors: Boyd Christina L. , Lynch Michael S. , Madonna Anthony J. 
Published: February 2016

AbstractOn November 21, 2013, U.S. Senate Democrats utilized the long threatened “nuclear option,” thereby allowing a simple-majority of the chamber to end debate on lower federal court judicial nominations. Formal theory predicts that this change should permit the president to nominate more ideologically extreme nominees. By comparing President Obama’s nominees before and after the Senate’s change to the confirmation process, we are able to provide the first comprehensive examination of how the nuclear option is likely to impact the ideological makeup of the lower federal courts. We additionally examine the impact of the nuclear option on time to confirmation and nominee success. Our results indicate, while post-nuclear option nominees are not significantly more liberal, they are being confirmed more often and more quickly, allowing Obama and Senate Democrats to more efficiently fill the federal judiciary with Democratic-leaning judges.
Dydrogesterone support following assisted reproductive technique (ART) reduces the risk of pre-eclampsia
Authors: Ali Anizah Bt , Ahmad Mohd Faizal B. , Kwang Ng Beng , Shan Lim Pei , Shafie Nasir Mohamed , Omar Mohd Hashim 
Published: February 2016

Abstract

Background:
Pre-eclampsia (PE) contributes to poor maternal morbidity and mortality. Progesterone is hypothesised to reduce the risk of PE.

Aim:
To determine the effect of progestogen supplementation during assisted reproductive technique (ART) in reducing the incidence of PE.

Method:
A retrospective comparative analysis among 1140 pregnancies between January 2006 and March 2015 conducted in a tertiary centre. A total of 570 pregnancies who conceived following ART with progesterone supplementation (study group) and an age-matched spontaneous pregnancies, without progesterone supplementation (control group, n=570) were included in the analysis. The study group received progesterone support following ART or intrauterine insemination (IUI) until 14–16 weeks’ gestation.

Results:
The rate of PE was significantly lower in the study group compared to control group (8.4% vs. 14.2%, p<0.05). Women supplemented with dydrogesterone only showed a lower PE incidence as compared to women received a combination of dydrogesterone and hydroxyprogesterone caproate, however, it was not statistically significant (6.9% vs. 9.9%; 6.9%; p=0.2).
Long-term BH4 (sapropterin) treatment of children with hyperphenylalaninemia – effect on median Phe/Tyr ratios
Authors: Tansek Mojca Zerjav , Groselj Urh , Kelvisar Matic , Kobe Helena , Lampret Barbka Repic , Battelino Tadej 
Published: February 2016

AbstractPhenylalanine hydroxylase deficiency causes various degrees of hyperphenylalaninemia (HPA). Tetrahydrobiopterin (BH4; sapropterin) reduces phenylalanine (Phe) levels in responders, enabling relaxation of dietary therapy. We aimed to assess long-term effects of BH4 treatment in HPA patients.Nine pre-pubertal BH4 responsive children were treated with BH4 for at least 2 years. The median dietary tolerance to Phe and levels of blood Phe, tyrosine (Tyr), zinc, selenium and vitamin B12 and anthropometric measurements, in the 2 years periods before and after the introduction of BH4 treatment were analyzed and compared. Adverse effects of BH4 were assessed.The daily Phe tolerance had tripled, from pretreatment median value of 620 mg (IQR 400–700 mg) to 2000 (IQR 1000–2000 mg) after 2 years of follow up (p<0.001). The median blood Phe levels during the 2 years period before introducing BH4 did not change significantly during the 2 years on therapy (from 200 μmol/L; IQR 191–302 to 190 μmol/L; IQR 135–285 μmol/L), but the median blood Phe/Tyr ratio had lowered significantly from pre-treatment value 4.7 to 2.4 during the 2 years on therapy (p=0.01). Median zinc, selenium, vitamin B12 levels and anthropometric measurements did not change while on BH4 therapy (p=NS). No adverse effects were noticed.BH4 therapy enabled patients much higher dietary Phe intakes, with no noticeable adverse effects. Median blood Phe and Tyr levels, median zinc, selenium, vitamin B12 levels and anthropometric measurements did not change significantly on BH4 therapy, but median Phe/Tyr ratios had lowered.
Synthesis, characterization, antimicrobial, and DNA cleavage evaluation of some organotin(IV) complexes derived from ligands containing the 1H-indole-2,3-dione moiety
Authors: Sharma Swati , Meena Ramhari , Singh R.V. , Fahmi Nighat 
Published: February 2016

AbstractNew Schiff bases 5-iodo-indol-2,3-dionehydrazinecarboxamide (L
Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling
Authors: de Melo Jimmy , Zibetti Cristina , Clark Brian S. , Hwang Woochang , Miranda-Angulo Ana L. , Qian Jiang , Blackshaw Seth 
Published: February 2016

Müller glia (MG) are the only glial cell type produced by the neuroepithelial progenitor cells that generate the vertebrate retina. MG are required to maintain retinal homeostasis and support the survival of retinal neurons. Furthermore, in certain vertebrate classes, MG function as adult stem cells, mediating retinal regeneration in response to injury. However, the mechanisms that regulate MG development are poorly understood because there is considerable overlap in gene expression between retinal progenitor cells and differentiated MG. We show that the LIM homeodomain transcription factorLhx2is required for the development of MG in the mouse retina. Temporally controlled knock-out studies reveal a requirement forLhx2during all stages of MG development, ranging from the proliferation of gliocompetent retinal progenitors, activation of Müller-specific gene expression, and terminal differentiation of MG morphological features. We show that Lhx2 regulates gliogenesis in part by regulating directly the expression of Notch pathway genes includingNotch1,Dll1, andDll3and gliogenic transcription factors such asHes1,Hes5,Sox8, andRax. Conditional knock-out ofLhx2resulted in a rapid downregulation of Notch pathway genes and loss of Notch signaling. We further demonstrate that Müller gliogenesis induced by misexpression of the potently gliogenic Notch pathway transcriptional effectorHes5requiresLhx2expression. These results indicate that Lhx2 not only directly regulates expression of Notch signaling pathway components, but also acts together with the gliogenic Notch pathway to drive MG specification and differentiation.SIGNIFICANCE STATEMENTMüller glia (MG) are radial glial cells located in the vertebrate retina that are essential for the function and survival of retinal neurons. We found the LIM homeodomain transcription factor Lhx2 to be expressed in both retinal progenitor cells and MG. Using conditional knock-outs, we show thatLhx2is required during all stages of MG development. We also show that Lhx2 regulates directly the expression of components of the Notch signaling pathway, which promotes retinal Müller gliogenesis, as well as multiple gliogenic transcription factors. We further demonstrate thatLhx2is required for Hes5-dependent gliogenesis. This study identifiesLhx2as a central transcriptional regulator of both Notch-dependent and Notch-independent components of retinal gliogenesis.
Acute Modulation of Cortical Glutamate and GABA Content by Physical Activity
Authors: Maddock Richard J. , Casazza Gretchen A. , Fernandez Dione H. , Maddock Michael I. 
Published: February 2016

Converging evidence demonstrates that physical activity evokes a brain state characterized by distinctive changes in brain metabolism and cortical function. Human studies have shown that physical activity leads to a generalized increase in electroencephalography power across regions and frequencies, and a global increase in brain nonoxidative metabolism of carbohydrate substrates. This nonoxidative consumption of carbohydrate has been hypothesized to include increasedde novosynthesis of amino acid neurotransmitters, especially glutamate and GABA. Here, we conducted a series of proton magnetic resonance spectroscopy studies in human volunteers before and after vigorous exercise (≥80% of predicted maximal heart rate). Results showed that the resonance signals of both glutamate and GABA increased significantly in the visual cortex following exercise. We further demonstrated a similar increase in glutamate following exercise in an executive region, the anterior cingulate cortex. The increase in glutamate was similar when using echo times of 30 and 144 ms, indicating that exercise-related T2 relaxation effects across this range of relaxation times did not account for the findings. In addition, we found preliminary evidence that more physical activity during the preceding week predicts higher resting glutamate levels. Overall, the results are consistent with an exercise-induced expansion of the cortical pools of glutamate and GABA, and add to a growing understanding of the distinctive brain state associated with physical activity. A more complete understanding of this brain state may reveal important insights into mechanisms underlying the beneficial effects of physical exercise in neuropsychiatric disorders, neurorehabilitation, aging, and cognition.SIGNIFICANCE STATEMENTIncreasing evidence suggests that distinctly different brain states are associated with sedentary behavior compared with physically active behavior. Metabolic studies show that the nonoxidative consumption of carbohydrates by the brain increases greatly during vigorous activity. Prior studies have suggested that one component of this metabolic shift may involve increasing the reserves of neurotransmitters in the brain viade novosynthesis from carbohydrate substrates. The current study reports the results of three experiments that support this hypothesis by showing increased cortical content of glutamate and GABA following physical activity. Understanding how brain metabolism and function differ during sedentary versus active behavioral states may provide important insights into the neurotherapeutic potential of exercise.
A Bright and Fast Red Fluorescent Protein Voltage Indicator That Reports Neuronal Activity in Organotypic Brain Slices
Authors: Abdelfattah Ahmed S. , Farhi Samouil L. , Zhao Yongxin , Brinks Daan , Zou Peng , Ruangkittisakul Araya , Platisa Jelena , Pieribone Vincent A. , Ballanyi Klaus , Cohen Adam E. , Campbell Robert E. 
Published: February 2016

Optical imaging of voltage indicators based on green fluorescent proteins (FPs) or archaerhodopsin has emerged as a powerful approach for detecting the activity of many individual neurons with high spatial and temporal resolution. Relative to green FP-based voltage indicators, a bright red-shifted FP-based voltage indicator has the intrinsic advantages of lower phototoxicity, lower autofluorescent background, and compatibility with blue-light-excitable channelrhodopsins. Here, we report a bright red fluorescent voltage indicator (fluorescent indicator for voltage imaging red; FlicR1) with properties that are comparable to the best available green indicators. To develop FlicR1, we used directed protein evolution and rational engineering to screen libraries of thousands of variants. FlicR1 faithfully reports single action potentials (∼3% ΔF/F) and tracks electrically driven voltage oscillations at 100 Hz in dissociated Sprague Dawley rat hippocampal neurons in single trial recordings. Furthermore, FlicR1 can be easily imaged with wide-field fluorescence microscopy. We demonstrate that FlicR1 can be used in conjunction with a blue-shifted channelrhodopsin for all-optical electrophysiology, although blue light photoactivation of the FlicR1 chromophore presents a challenge for applications that require spatially overlapping yellow and blue excitation.SIGNIFICANCE STATEMENTFluorescent-protein-based voltage indicators enable imaging of the electrical activity of many genetically targeted neurons with high spatial and temporal resolution. Here, we describe the engineering of a bright red fluorescent protein-based voltage indicator designated as FlicR1 (fluorescent indicator for voltage imaging red). FlicR1 has sufficient speed and sensitivity to report single action potentials and voltage fluctuations at frequencies up to 100 Hz in single-trial recordings with wide-field microscopy. Because it is excitable with yellow light, FlicR1 can be used in conjunction with blue-light-activated optogenetic actuators. However, spatially distinct patterns of optogenetic activation and voltage imaging are required to avoid fluorescence artifacts due to photoactivation of the FlicR1 chromophore.
The Impact of Public Access Venue Information and Communication Technologies in Botswana Public Libraries
Authors: Totolo Angelina , Renken Jaco , Sey Araba 
Published: February 2016

Abstract

Objective – A study on the impact of Public Access Venue (PAV) Information and Communication Technologies (ICTs) was conducted in Botswana libraries with Internet connections. The main objective was to determine the impact of ICTs in public libraries.
Methods –Using the Sustainable Livelihoods Framework as a theoretical lens, the study used semi-structured interviews and focus group discussions to investigate the impact of PAV ICTs in 4 study sites, resulting in data from a total of 39 interviews and 4 focus groups.
Methods –Using the Sustainable Livelihoods Framework as a theoretical lens, the study used semi-structured interviews and focus group discussions to investigate the impact of PAV ICTs in 4 study sites, resulting in data from a total of 39 interviews and 4 focus groups.

Results – The results of the study show that PAV ICTs had a positive impact on users in the areas of education and economic benefits. Within educational and economic impacts, social benefits were also found, pertaining to the use of social media and the Internet for formal and informal communication. The study also revealed a slight difference between school going users and non-school going elderly users where the use and acquisition of computer skills was concerned. Elderly non-school going users tended to rely on venue staff for skills more than the younger school going users.

Conclusion – The study recommends that PAV facilities should be improved in terms of skills offered and resources availed so as to appeal to both the younger school going generation and the older non-school going users. It is also recommended that education on ICT be improved to help curb rising unemployment in Botswana; such skills would enhance the income generation skills of the unemployed users as well as school leavers.
The Role Of Negative Information In Dissolving Consumer Identification With Companies
Authors: Rozensher Susan G. , Fergenson P. Everett 
Published: February 2016

A benefit of strong consumer identification with a company has been hypothesized to be consumers’ greater resilience to negative information about the company. The positive consequences of strong consumer-company identification, however, have been proposed to have their limits, or “zone of tolerance”. The present study extended and tested the “zone of tolerance” hypothesis by measuring reactions of company-identified consumers when confronted with negative information that challenged their strong identification with the company.
Do Impact Fees Pay For The Infrastructure Costs Required By New Developments?
Authors: Apap Antonio , Cicheskie Dana L. 
Published: February 2016

This study investigated impact fees used by counties and communities to pay for infracture costs required by development and found that the impact fees do not pay the full costs of the infrastructure required by the new development. The major impact fees are for roads and schools, however, impact fees are also routinely used for fire protection, police protection, emergency services, correctional facilities, parks, libraries, government buildings and drainage. Florida was used as a proxy for the 34 states that use impact fees. Since roads and schools cause the highest burden on the communities experiencing growth, comparisons of cost vs. impact fee revenues were limited to roads and schools.
Bundling And Small Business Operations
Authors: Boronico Jess , Murdy James , Loughlin Selene 
Published: February 2016

The purpose of this paper is to develop and test a model for managing the inventory for a small, student managed food service business. The Hazell Nut Café offers six coffees, six flavors of ice cream, four teas, hot chocolate, assorted pastries, bottled water, vitamin water, and four other types of cold beverages. The purveyors for the all supplies, with the exception of dairy products, have on-call deliveries, but pre-set minimums for order quantities. The dairy company requires a minimum weekly delivery. After nearly one year of operation, the café’s student-managers are still developing an inventory management system. The model developed here seeks to provide an easy to understand solution to the supply chain problems encountered by a small business such as the Hazell Nut Café.
Mitigating NPD And R&D Risks Via A Portfolio Effect In Country Choice
Authors: Buskirk Bruce , Reynolds Ken , Schmidt Stacy M.P. , Ralph David L. 
Published: February 2016

New Product Development as well as Research and Development projects tend to be inherently risky investments. Most MNC’s today have great latitude in choosing site and country locations to build or contract Research or Development projects. MNC R&D risks, corporate wide, can be moderated via a diversification of NPD/R&D projects across multiple cultures and countries. In fact there is some evidence that R&D global diversification can generate synergies. (Fast track projects that work around the clock via work being done in three locations each 8 hours off from the other.) Foreign R&D facilities can help serve as outposts to facilitate the entrance into strategic foreign markets. This paper attempts to develop decision methodologies for allocating NPD/R&D globally with the goal of both reducing risks and increasing global competitiveness.
Lessons Learned From Using An Ill-Conceived Nonmonetary, Prepaid Incentive In A Self-Administered Survey Of College Students
Authors: Dommeyer Curt J. , Romero Melissa , Tafazzoli Kevin M. 
Published: February 2016

An experiment was conducted to determine how effective a prepaid, nonmonetary incentive would be at inducing college students to participate in a self-administered survey. The experiment was conducted on two college campuses in Los Angeles County. As students exited their campus library, an interviewer approached them for an interview. Half of those approached were offered a prepaid, nonmonetary incentive; the other half were not. Contrary to expectations, the prepaid, nonmonetary incentive dampened the response rate to the survey. Explanations are offered as to why the incentive was counterproductive.
Características epidemiológicas de la enfermedad periodontal e higiene oral en mujeres en etapa de embarazo y lactancia materna
Authors: Yllesca-Yllesca Ivonne , Manrique-Chávez Jorge Enrique , Chávez-Reátegui Beatriz Del Carmen 
Published: February 2016

Objetivo: Comparar las características epidemiológicas de la enfermedad periodontal y la higiene oral entre mujeres que se encuentren en etapa de gestación y mujeres que se encuentran en periodo de lactancia de unacomunidad urbano marginal de Lima-Perú en el 2014. Materiales y Métodos: Cuarenta mujeres agrupadas según el trimestre de gestación y cuarenta mujeres agrupadas según el bimestre de lactancia, fueron evaluadas empleando el índice de higiene oral simplifi cado, índice periodontal comunitario y el índice de pérdida de fi jación. Resultados: Se realizó las pruebas estadísticas Chi Cuadrado y Test Exacto de Fisher para comparar ambos grupos. No se encontró diferencias estadísticamente signifi cativas entre gestantes y lactantes al comparar la higiene oral, el sangrado al sondaje y la pérdida de fijación. Sin embargo se halló diferencias estadísticamente signifi cativas con respecto a las bolsas periodontales, siendo más prevalentes en gestantes. Además es importante mencionar que las bolsas periodontales disminuyeron progresivamente a medida que avanzaban los trimestres delactancia. Conclusión:Durante el embarazo, se presentaron más características epidemiológicas de enfermedad periodontal que en el periodo de lactancia materna, a pesar de que, ambos grupos tuvieron las mismas condiciones de higiene oral.