bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Kidney Injury after Liver Transplantation
Authors: Martina Konkolova , Lubomir Skladany , Marcel Cellar , Patricia Kleinova , Timea Blichova , Monika Beliancinova , Karol Granak , Ivana Dedinska 
Published: September 2024

Abstract
Liver transplantation is the only curative treatment for terminal liver failure. Advances in immunosuppressive therapy and improvements in surgical techniques have improved patient survival in the post-transplant period. At the same time, however, the incidence of late complications is increasing, which has been contributed to by the broadening of the indication criteria in liver allocation. The most common complications include chronic kidney disease, the aetiology of which is multifactorial with a predominance of calcineurin inhibitor toxicity in the post-transplant period. The prevalence ranges from 30% to 90% depending on the definition used and the methodology used to measure renal function. Early detection of risk factors and early intervention lead to a significant improvement in the quality of life of recipients in the post-transplant period.
Implementation of Early Detection of Lung Tuberculosis Using Who Systematic Screening Guidelines at the Public Health Center in Indonesia
Authors: Zuhair M. N. , Nas A. R. , Lautan R. , Anugrawan W. , Yusuf  , Hanif A. M. , Sardi N. A. 
Published: September 2024

Abstract

Background
Tuberculosis remains a pressing public health concern in Indonesia, ranking second globally after India. Factors contributing to Indonesia’s high TB incidence include lengthy treatment, rising HIV/AIDS cases, and multi-drug resistant TB. Effective TB control focuses on targeted screening, avoiding costly mass screening. This study explores early lung TB detection using WHO systematic screening at Tamalate District, Makassar, Indonesia, addressing screening challenges and program management concerns.

Method
This descriptive observational study was performed on 153 patients, using primary data from systematic screening following WHO guidelines and a mobile outreach campaign in Tamalate District, Makassar, Indonesia, over 15 days in August 2023. Data were categorized into non-suspected lung TB and suspected lung TB. Suspected cases underwent GeneXpert MTB/RIF testing for TB and rifampicin resistance detection. Patients were divided into four groups – patients with non-suspected TB, suspected TB, diagnosed TB, and drug-resistant TB.

Result
Based on screened patient characteristics results, there was a higher distribution of males than females. In contrast, the mean age of our total sample was approximately 48.07 ± 16.37, which tended toward the <55 age group. Regarding the WHO systematic screening method results, we found that 44 had non-suspected lung tuberculosis, 36 had suspected lung tuberculosis but could not expel sputum, 47 were MTB-negative, and 10 were confirmed MTB-positive, and treatment was initiated.

Conclusion
This study highlights the effectiveness and efficiency of implementing the WHO systematic screening for active tuberculosis, which was previously not integrated into the Indonesian health system, particularly in the Tamalate District of Makassar, Indonesia.
The Presence of Monosodium Urate Deposits in the Joints of Patients with Asymptomatic Hyperuricemia is Associated with a Higher Cardiovascular Risk, But Not with More Advanced Kidney Damage
Authors: Gancheva R. , Koundurdjiev A. , Kundurzhiev T. , Kolarov Zl. , Peteva P. , Nikolova M. , Koundurdjieva I. , Yankova P. , Monov S. , Marinchev L. 
Published: September 2024

Abstract

Aim
To evaluate the association between asymptomatic hyperuricemia, renal damage and cardiovascular events and to investigate whether the presence of monosodium urate (MSU) deposits in the joints is related to more advanced renal changes and increased cardiovascular risk.

Methods
This was a study on 73 consecutive patients divided into 34 patients with osteoarthritis, 25 subjects with asymptomatic hyperuricemia and no ultrasound (US) evidence of MSU crystals in the joints and 14 individuals with asymptomatic hyperuricemia and MSU deposits in the joints. Patients underwent bilateral US examination of the joints of the hands, elbows, knees, ankles, feet and the kidneys. Routine abdominal ultrasound with evaluation of kidney and parenchymal size and echogenicity and renal vascular indices was performed. The presence of cardiovascular complications in the past was evaluated from the patients‘ history. The study protocol was a continuation of another project from 2013 (14-D2013, approved by the ethics committee of the Medical University – Sofia). Informed consent was obtained from all patients prior to the inclusion in the study. The study was conducted in accordance with the Declaration of Helsinki.

Results
The highest proportion of patients with cardiovascular events was detected in the group of asymptomatic hyperuricemia with MSU deposits in the joints. The patients with osteoarthritis had the lowest prevalence of eGFR < 90 ml/min. Renal parenchymal echogenicity and the prevalence of nephrolithiasis were compatible for all groups. Patients with hyperuricemia and MSU deposits in the joints had higher BMI (p = 0.018) and smaller kidney size (p = 0.015) compared to those with osteoarthritis. The comparison of hyperuricemia without MSU deposits in the joints to osteoarthritis group demonstrated a significant difference only in the age (p = 0.001). Finally, the comparison of the two groups with hyperuricemia showed that subjects with MSU deposits in the joints had higher BMI (p = 0.041) with no difference in the age, kidney size, RRI, eGFR and thickness of renal parenchyma.

Conclusions
Hyperuricemia, independent of the presence of articular crystals, is associated with compatible kidney damage. Cardiovascular risk is higher when MSU crystals are detected in the joints using US.
Upper Eyelid Blepharoplasty: An Approach for a Simplified, Safe and Effective Procedure
Authors: Yordanov Y. P. 
Published: September 2024

Abstract

Background
Upper blepharoplasty has significantly evolved over the past two decades from the unified routine excision of skin, muscle, and fat to a sophisticated and individualized to the patients’ needs surgical intervention. The contemporary techniques aim to correct age-related changes while preserving or even improving anatomy and function.

Objectives
To demonstrate the author’s personal approach for obtaining safe and reliable results in aesthetic upper eyelid surgical rejuvenation.

Material and methods
A retrospective chart review was conducted encompassing patients who underwent aesthetic upper blepharoplasty performed by a single surgeon in an ambulatory setting under local anesthesia between September 2020 and August 2023. A minimum follow-up of 9-month was established. Cases with concurrent periorbital or facial surgery, any previous surgical and non-surgical procedures on the eyelids and any underlying eyelid pathologies and comorbidities that could affect the eyelids were excluded from the study.

Results
A total of 137 consecutive patients (mean age, 51.09 years; range, 32-77 years) were found and studied. Out of them, 119 were female (n = 119; 86.86%) and 18 were male (n = 18; 13.14%). Analysis of the obtained results demonstrated significant aesthetic improvement and high satisfaction rate among the patients with no major complications in the series.

Conclusions
The described technique has shown to be safe and effective approach for upper eyelid surgical rejuvenation with reproducible and reliable results. It gives a natural outcome and also an improved quality of life which is of particular importance for elderly patients and those with excessive dermatochalasis.
Association of Markers of Bone Mineral Disease and Left Ventricular Hypertrophy in Patients of Chronic Kidney Disease
Authors: Aggarwal H. K. , Jain D. , Kaur S. , Dahiya S. , Harish P. , Kumar A. 
Published: September 2024

Abstract

Background. Chronic kidney disease (CKD) is an epidemic health problem responsible for an increase in morbidity and mortality secondary to various complications, especially cardiovascular events. Previous studies have suggested that biochemical markers of metabolic bone disease (MBD) are associated with an increase in cardiovascular events by causing left ventricular hypertrophy (LVH). Therefore, the present study aimed to evaluate the association between LVH and CKD-MBD markers as a major predictor for cardiovascular disease (CVD) in CKD patients.

Materials and Methods. A single-center, cross-sectional, observational study was carried out at a tertiary care center. A total of 50 CKD patients, stages 3-5, not on dialysis, were included. Demographic details, clinical history, laboratory investigations and echocardiography were obtained. The presence of LVH was determined on the basis of echocardiography, and it was associated with CKD stages and biochemical markers, including CKD-MBD markers.

Results. Seventy-two percent of CKD patients had LVH. The proportion of patients with LVH significantly increased with a declining estimated glomerular filtration rate (eGFR). Hypertension was considerably higher in patients with LVH (63.89%). Significant association of LVH was seen with serum creatinine, corrected calcium, phosphorus, total cholesterol, fibroblast growth factor 23 (FGF-23), vitamin D, intact parathyroid hormone (iPTH), eGFR, left ventricular mass index (LVMI) and ejection fraction (p-value < 0.05). On multivariate regression, FGF-23 had a significant positive correlation with LVH (p-value < 0.05, odds ratio > 1). A significant positive correlation was observed between LVMI and systolic blood pressure, serum creatinine, phosphorus, total cholesterol, iPTH, and FGF-23. A significant negative correlation was seen with LVMI and hemoglobin, corrected serum calcium, albumin, eGFR, vitamin D and ejection fraction.

Conclusion. The present study shows CKD-MBD markers, including serum calcium, phosphorous, vitamin D, iPTH and FGF-23, are significantly associated with LVH. FGF-23 is an independent predictor of LVH. The present study also demonstrates that CKD-MBD biochemical markers are reliable for screening CVD in CKD patients.
Self-Perceived Health and Life Satisfaction During COVID-19 Pandemic
Authors: Naseva E. , Baev M. , Baev G. , Stoilchev G. , Shtereva-Tzouni D. 
Published: September 2024

Abstract

The aim of the study was to assess both self-perceived health and life satisfaction during one of COVID-19 pandemic peaks and to reveal their correlates among the study characteristics.

Materials and methods. An online survey was conducted at the end of 2020 among 930 participants recruited via Facebook.

Results. A quarter of the participants (26.2%) rated their own health as very good, 47.1% – as good, for 22.8% it was satisfactory, 2.9% claimed it as bad and 0.9% as very bad. Life satisfaction was measured by a 10-point scale ranging from 1 “very unsatisfied” to 10 – “very satisfied“. The median level of satisfaction was 6 (IQR 3-8). With the decrease of self-perceived health a significant drop of life satisfaction was observed (Kendall’s tau = 0.172, p < 0.001). No significant difference was noticed in both self-perceived health and life satisfaction between patients who had suffered from COVID-19 and those who had not (p > 0.05). Self-perceived health was positively correlated with self-perceived living standard (Kendall’s tau = 0.118, p < 0.001) and negative with age (Kendall’s tau = -0.112, p < 0.001). Females’ health was significantly worse (p=0.006) and also single, divorced and widowed reported significantly worse health compared to married/in a steady relationship (p = 0.019). Life satisfaction was positively correlated with net monthly income (Kendall’s tau = 0.199, p < 0.001), self-perceived living standard (Kendall’s tau = 0.246, p < 0.001) and education (Kendall’s tau = 0.101, p < 0.001). Married or in a steady relationship reported significantly higher life satisfaction than single, divorced and widowed (p = 0.001).

Conclusion. Better economic status and living with spouse or having a steady partner (instead of being single, divorced or widowed) helps individuals to maintain better health and subjective well-being during pandemics.
Analysis of Genetic Polymorphisms of OCT1, MATE1, MATE2 and GLP1R in Rats with Experimentally Induced Obesity
Authors: Kalinkova M. , Kadiyska T. , Dabchev K. , Bogdanov G. , Handjieva-Darlenska T. 
Published: September 2024

Abstract
The experimental model of obesity based on a cafeteria diet is a common model to investigate different aspects of obesity. The present study aimed to evaluate the link between genetic variants of OCT1, MATE1, MATE2 and GLP1R and the treatment effects in male obese rats. After 19-weeks of feeding with a standard chow food and Cafeteria-diet (CAF), the rats were divided into three groups: control group (only CAF), metformin group (CAF and metformin treatment) and liraglutide group (CAF and GLP1 agonist treatment). The genetic variations of the receptors for metformin in liver and kidney (OCT1, MATE1, MATE2) and for liraglutide (GLP1R) were examined. The results demonstrated a significant decrease in body mass index, blood glucose and a significant increase in plasma HDL-cholesterol levels in both groups treated with either metformin or liraglutide compared to the control group. No effect on plasma triglycerides and VLDL-cholesterol levels was shown between the three groups. According to the genetic analysis, all rats were “wild type” for the genetic variants tested in OCT, MATE1, MATE2 and GLP1R, not affecting the effects of treatment. This raises the possibility of other potential genes implicated in the underlying mechanism of obesity and metformin/liraglutide therapy.
Overlap Syndromes in Autoimmune Connective Tissue Diseases
Authors: Dourmishev L. A. 
Published: September 2024

Abstract
Autoimmune connective tissue diseases are a group of immune disorders, characterized by different clinical features, which affects not only the skin but also different organs and systems. Such diseases include: rheumatoid arthritis, systemic lupus erythematosus, Sjögren’s syndrome, systemic sclerosis, dermatomyositis and polymyositis. However, there are patients that fulfil the diagnostic criteria of more than one disorder, thus supporting the concept of the so called “overlap syndromes”. The aim of this review is to present the history, clinical and immunologic hallmarks of these overlap syndromes. Such conditions are scleromyositis, lupus erythematosus/lichen planus overlap, Sharp’s syndrome, Rhupus syndrome, Rowell’s syndrome, Reynolds syndrome and Senear-Usher syndromes. Patients with these syndromes usually do not meet most of the diagnostic criteria of “classic” connective tissue diseases and this usually causes diagnostic difficulties. Overlap syndromes are commonly treated with corticosteroids, hydroxychloroquine and immunosuppressant drugs as a first-line treatment. The new therapeutic molecules that precisely interact with immune mechanisms will require accurate diagnosis and a better understanding of the pathogenesis of the overlap syndromes.
Control of yersiniosis in rainbow trout, Oncorhynchus mykiss: innovative non-antibiotic feed-based strategies
Authors: Abdel-Latif Hany M.R. , Citarasu Thavasimuthu , Turgay Emre , Yilmaz Ebru , Yousefi Morteza , Shekarabi Pezhman Hosseini , Ahmadifar Ehsan , Nowosad Joanna , Kucharczyk Dariusz , Yilmaz Sevdan 
Published: September 2024

Abstract
Yersiniosis or enteric redmouth (ERM) is responsible for significant mortalities among rainbow trout and other salmonids. Hence, its prevention and/or control has become a research hotspot. Antibiotics are effective for control; however, accumulating evidence indicates that unrestricted use of antibiotics harms fish, human beings, and the environment. Thus, finding safe, efficacious, cost-effective, and environmentally friendly substitutes is of great interest. Reports showed that dietary supplementation with functional additives with health-promoting and immunostimulatory functions could be a promising strategy. Herein, we provide an overview of the non-antibiotic feed-based strategies for combating EMR in rainbow trout without resorting to antibiotic usage. For this issue, the uses and application of some vitamins, probiotics, prebiotics, synbiotics, quorum quenching probiotic strains, algae, or organic acids, are included in the article. The roles of phytobiotics (herbal supplements), their phytochemicals, and the essential oils extracted from them will also be elucidated. Some emerging nano-based feed supplements are also discussed. Considering their advantages, literature declared that the dietary supplementation of these supplements could enhance the overall health condition, haemato-immunity, and disease resistance and conferred high protection of trout experimentally infected with yersiniosis. Given this perspective, this article presents the current situation and the latest knowledge on these supplements, emphasizing not only their roles to support immunity and decrease the effects of EMR but also to minimize antibiotic usage in aquaculture. Limitations and future perspectives on their effectiveness and efficacy are also discussed. This review will help enhance aquaculture sustainability and improve the health and welfare of rainbow trout.
Supplementing Nile tilapia (Oreochromis niloticus) (Linnaeus, 1758) larvae with dietary beta-glucan could improve their growth, survival, immune function, intestinal and liver histomorphology
Authors: AbouShabana Nevine M. , Aboseif Ahmed M. , Taha Mostafa K.S. , Ramadan Enas A. , Elhammady Ahmed K. I. , Ashour Mohamed , Doan Hien Van , El-Haroun Ehab , Goda Ashraf M. A-S. 
Published: September 2024

Abstract
Β-glucan exerts a positive impact and consider as a functional feed additives to enhance fish growth, immunity, control disease outbreaks and pathogen infections by increasing functional, immune and decreasing harmful responses. The present study aimed to determine the most effective dietary level of beta-glucan (βG) to improve Nile tilapia Oreochromis niloticus (L.) fry growth performance, feed utilization, and hematological indicators. Seven isonitrogenous (32% crude protein) and isocaloric diets (18 MJ/kg) were formulated. All diets were identical except for the variation in βG levels.The basal experimental diet (control diet) had no βG added. Diets 2–7 each contained βG at levels of 250, 500, 1000, 2000, 4000, and 8000 mg/kg diet, respectively. A total of 840 fish with an average body weight of 0.2±0.01 g were allocated into the seven experimental treatments (in triplicate). The trial lasted for 120 days, Nile tilapia fry growth performance and feed utilization were significantly (P≤0.05) higher in all treatments receiving βG diets than in the control diet. The fish fed with ßG0.1 diet showed the highest significant growth induces and the best FCR values. The survival (S%) of the fish also showed a significant increase in the βG diets up to ßG0.8 levels, when compared to the other experimental diet groups. All hematological parameters increased (P≤0.05) in fish fed with a diet supplemented up to ßG0.8 compared to the control group. Histological examination of the intestine and liver in the control group revealed histopathological alterations in the villi. On the other hand, the groups treated with βG had longer and structurally normal villi. The most well-preserved intestinal tissue and the tallest villi were observed in ßG0.1, followed by ßG0.050 and ßG0.8 groups. In the liver, the control group exhibited fatty degeneration, necrosis and pyknosis whereas the ßG0.1 group displayed the most preserved hepatic tissue, followed by ßG0.8 and ßG0.2 groups. The results indicate that according to FBW-based broken-line model analysis, the optimal dietary level of βG for Nile tilapia fry to exhibit superior growth and diet utilization efficiency associated with the best FCR for Nile tilapia should be 0.12% βG /kg diet. To increase the immunity of fish and improve the properties of hematological and histopathological indices, the dose can be increased to 0.8% βG without any adverse effects.
Progress and research trends in lumpy skin disease based on the scientometric assessment – a review
Authors: Zeeshan Hafiz Muhammad , Heyat Md Belal Bin , Hayat Mohd Ammar Bin , Parveen Saba , Sultana Arshiya , Akhtar Faijan , Iqbal Abid , Ali Ahmad , Pomary Dustin , Ogunsakin Ropo Ebenezer , Abdelgeliel Asmaa Sayed 
Published: September 2024

Abstract

Background
Lumpy skin disease (LSD) has been a significant concern in veterinary medicine since its discovery. Despite decades of research, understanding the full spectrum of this disease remains a challenge. To address this gap, a comprehensive analysis of the existing body of knowledge on LSD is essential. Bibliometric analysis offers a systematic approach towards the mapping of research landscape, identifying key contributors, and uncovering emerging trends in LSD research.

Objective
This study aims to conduct a thorough bibliometric analysis spanning from 1947 to till the present date in order to map the knowledge domain of LSD. The objective is to gain insights into the global research trends, identify influential contributors, explore collaboration networks, and predict future outlook in LSD research.

Method
Data extracted from the Scopus database was used to perform a bibliometric analysis. 341 relevant documents were selected for analysis. Bibliometric indicators, including publication numbers, citation counts, and the h-index, were utilized to assess the comprehensive contributions of nations, organizations, authors, and source titles. Additionally, cooperation networks between countries, organizations, and authors were visualized using the VOSviewer tool.

Results
The analysis revealed a significant increase in research output on LSD, with a notable growth rate of 19.26%. Since its discovery in Zambia in 1929, LSD research has grown steadily, with an average annual growth rate of 5.21%. The University of Pretoria and the Federal Centre for Animal Health emerged as the most active institutions and organizations in LSD research. The Journal of Virology was identified as the most cited journal, reflecting its significant impact on the field, and a strong international collaboration was observed between the United Kingdom and South Africa.

Conclusion
This study provides valuable insights into the global research landscape of LSD, highlighting key trends, contributors, and collaboration networks. By reviewing decades of research, this analysis enhances our understanding of LSD and serves as a foundation for future research endeavours. The findings of this study will aid researchers in navigating the vast literature on LSD, ultimately contributing to advancements in veterinary medicine and disease management strategies.