bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards Using Tiny Sensors with Heat Balancing Criteria for Child Care Reminders
Authors: Poon Geoffrey , Kwan Kin Chung , Pang Wai-Man , Choi Kup-Sze 
Published: December 2016

Raising children is challenging and requires lots of care. Parents always have to provide proper care to their children in time, like hydration and clothing. However, it is difficult to always stay alert or be aware of the care required at proper moments. One reason is that parents nowadays are busy. This especially applies to single parent, or the one who needs to raise multiple children. This paper presents the use of an integrated multi-sensors together with a mobile application to help keep track of unusual situations concerning a child. By monitoring the changes in surrounding temperature, motions, and air pressure acquired from the sensors, our mobile application can infer the physiological needs of the children with the heat equilibrium assumption. As the thermal environment in the human body is mainly governed by the heat balance equation, we fuse all available sensor readings to the equation so as to estimate the change in situation of a child over a certain period of time. Our system can then notify the parents of the necessary care, including hydration, dining, clothing and ear barotrauma relieving. The proposed application can greatly relieve some of the mental load and pressure of the parents in taking care of children.
A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells
Authors: Ishikawa Yoshinori , Gamo Kanae , Yabuki Masato , Takagi Shinji , Toyoshima Kosei , Nakayama Kazuhide , Nakayama Akiko , Morimoto Megumi , Miyashita Hitoshi , Dairiki Ryo , Hikichi Yukiko , Tomita Naoki , Tomita Daisuke , Imamura Shinichi , Iwatani Misa , Kamada Yusuke , Matsumoto Satoru , Hara Ryujiro , Nomura Toshiyuki , Tsuchida Ken , Nakamura Kazuhide 
Published: December 2016

Abstract
Dysregulation of lysine (K)-specific demethylase 1A (LSD1), also known as KDM1A, has been implicated in the development of various cancers, including leukemia. Here, we describe the antileukemic activity and mechanism of action of T-3775440, a novel irreversible LSD1 inhibitor. Cell growth analysis of leukemia cell lines revealed that acute erythroid leukemia (AEL) and acute megakaryoblastic leukemia cells (AMKL) were highly sensitive to this compound. T-3775440 treatment enforced transdifferentiation of erythroid/megakaryocytic lineages into granulomonocytic-like lineage cells. Mechanistically, T-3775440 disrupted the interaction between LSD1 and growth factor–independent 1B (GFI1B), a transcription factor critical for the differentiation processes of erythroid and megakaryocytic lineage cells. Knockdown of LSD1 and GFI1B recapitulated T-3775440–induced transdifferentiation and cell growth suppression, highlighting the significance of LSD1–GFI1B axis inhibition with regard to the anti-AML effects of T-3775440. Moreover, T-3775440 exhibited significant antitumor efficacy in AEL and AMKL xenograft models. Our findings provide a rationale for evaluating LSD1 inhibitors as potential treatments and indicate a novel mechanism of action against AML, particularly AEL and AMKL. Mol Cancer Ther; 16(2); 273–84. ©2016 AACR.
Cross-border Healthcare in the eu: And What if Something Goes Wrong?
Authors: Paskalia Vicki 
Published: December 2016

Abstract
In March 2011, a new Directive was adopted by the European Parliament and the Council of the European Union: Directive 2011/24, on the application of patients’ rights in cross-border healthcare, the primary purpose of which has been to facilitate access to healthcare across national borders. Healthcare safety and the availability of legal remedies in cases of harm are important parameters of quality healthcare and important patients’ rights in modern healthcare systems, and they are therefore important issues in a context of cross-border patient mobility. The aim of this article is to shed some light on the provisions of the Healthcare Directive in relation to the issue of legal remedies in cases of harm. It is argued that the current legal state should be considered unsatisfactory, problematic and in need of more clarity and even harmonisation.
Sayyid Yusuf’s 1433 Pilgrimage Scroll (Ziyārātnāma) in the Collection of the Museum of Islamic Art, Doha
Authors: Chekhab-Abudaya Mounia , Couvrat Desvergnes Amélie , Roxburgh David J. 
Published: December 2016

A pilgrimage scroll (ziyārātnāma) dated 1433 in the name of Sayyid Yusuf b. Sayyid Shihab al-Din Ma Waraʾ al-Nahri records an ʿumra to Mecca and visits (ziyārāt) to Medina, Jerusalem, Hebron, Najaf, and Karbala. This document reflects a common phenomenon in the central Islamic lands of the post-Mongol and pre-Safavid period, namely, the non-sectarian veneration of the family of the Prophet Muhammad, and its narrative provides unusually rich details about the pilgrim’s objectives in commissioning it. Given the rarity of this document and the lack of any scholarly study of it, two art historians and one conservation scientist here present an in-depth analysis of its materials, techniques of production, format, form, topographic representations, and calligraphy. The scroll is also considered vis-à-vis comparative materials, which are admittedly scant in number.
Correlates of Hepatitis C Virus Infection in the Targeted Testing Program of the New York City Jail System
Authors: Akiyama Matthew J. , Kaba Fatos , Rosner Zachary , Alper Howard , Kopolow Aimee , Litwin Alain H. , Venters Homer , MacDonald Ross 
Published: December 2016

Objective: The objective of this study was to understand predictors of hepatitis C virus (HCV) antibody positivity in a large urban jail system in New York City. Methods: We examined demographic characteristics, risk behaviors, and HCV antibody prevalence among 10 790 jail inmates aged 16 to 86 who were screened from June 13, 2013, to June 13, 2014, based on birth cohort or conventional high-risk criteria. We used logistic regression analysis to determine predictors of HCV antibody positivity. Results: Of the 10 790 inmates screened, 2221 (20.6%) were HCV antibody positive. In the multivariate analysis, HCV antibody positivity was associated most strongly with injection drug use (IDU; adjusted odds ratio [aOR] = 35.0; 95% confidence interval [CI], 28.5-43.0). Women were more likely than men to be infected with HCV (aOR = 1.3; 95% CI, 1.1-1.5). Compared with non-Hispanic black people, Hispanic (aOR = 2.1; 95% CI, 1.8-2.4) and non-Hispanic white (aOR = 1.7; 95% CI, 1.5-2.1) people were more likely to be infected with HCV. Non-IDU, recidivism, HIV infection, homelessness, mental illness, and lower education level were all significantly associated with HCV infection. The prevalence rate of HCV infection among a subset of inmates born after 1965 who denied IDU and were not infected with HIV was 5.6% (198 of 3529). Predictors of HCV infection among this group included non-IDU as well as being non-Hispanic white, Hispanic, recidivist, and homeless. Conclusion: These data reveal differences in HCV infection by sex, race/ethnicity, and socioeconomics in a large jail population, suggesting that a focused public health intervention is required and that universal screening may be warranted. Further sensitivity and cost-benefit analyses are needed to make this determination.
Quantifying the aggregate thermal performance of UK holiday homes
Authors: Johnston David , Farmer David , Miles-Shenton Dominic 
Published: December 2016

In the UK, there are approximately 330,000 holiday homes spread across a large number of mainly privately owned sites. These homes are often sited in exposed locations, are poorly insulated and are generally heated using expensive fuels, such as electricity or LPG. There is also a lack of empirical evidence available on the in situ energy performance of these homes. Consequently, it is not possible, given the existing evidence base, to determine whether these homes suffer from the same scale of building fabric thermal ‘ performance gaps’ (between assumed and realised in situ performance) that have been documented for newbuild UK housing. This paper presents the results obtained from undertaking detailed in situ thermal fabric tests on five new holiday homes. Whilst the size reported here is small, the results indicate that a ‘ performance gap’ exists for all of these homes. Results obtained indicate that this gap appears narrower than that documented for newbuild UK housing. The results also suggest that the scale of the ‘ gap’ may be more a consequence of the way in which the design intent of these homes has been determined, i.e. a ‘ prediction gap’. Practical application: This paper presents the results obtained from undertaking detailed building fabric thermal performance tests on a small sample of new holiday homes. The results of these tests indicate that although a building fabric thermal performance ‘ performance gap’ exists in all of the holiday homes tested, the results suggest that the ‘ gap’ is much smaller than that documented for new build UK housing and may be more of a consequence of the way in which the design intent of these homes has been determined, i.e. a ‘ prediction gap’, rather than a ‘ performance gap’ between assumed and realised in situ performance. These results could be used by industry to develop more appropriate prediction tools that are relevant to holiday homes.
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial
Authors: Ross Stephen , Bossis Anthony , Guss Jeffrey , Agin-Liebes Gabrielle , Malone Tara , Cohen Barry , Mennenga Sarah E , Belser Alexander , Kalliontzi Krystallia , Babb James , Su Zhe , Corby Patricia , Schmidt Brian L 
Published: December 2016

Background: Clinically significant anxiety and depression are common in patients with cancer, and are associated with poor psychiatric and medical outcomes. Historical and recent research suggests a role for psilocybin to treat cancer-related anxiety and depression. Methods: In this double-blind, placebo-controlled, crossover trial, 29 patients with cancer-related anxiety and depression were randomly assigned and received treatment with single-dose psilocybin (0.3 mg/kg) or niacin, both in conjunction with psychotherapy. The primary outcomes were anxiety and depression assessed between groups prior to the crossover at 7 weeks. Results: Prior to the crossover, psilocybin produced immediate, substantial, and sustained improvements in anxiety and depression and led to decreases in cancer-related demoralization and hopelessness, improved spiritual wellbeing, and increased quality of life. At the 6.5-month follow-up, psilocybin was associated with enduring anxiolytic and anti-depressant effects (approximately 60–80% of participants continued with clinically significant reductions in depression or anxiety), sustained benefits in existential distress and quality of life, as well as improved attitudes towards death. The psilocybin-induced mystical experience mediated the therapeutic effect of psilocybin on anxiety and depression. Conclusions: In conjunction with psychotherapy, single moderate-dose psilocybin produced rapid, robust and enduring anxiolytic and anti-depressant effects in patients with cancer-related psychological distress. Trial Registration: ClinicalTrials.gov Identifier: NCT00957359
Measuring Nutrition Governance
Authors: Webb Patrick , Ghosh Shibani , Shrestha Robin , Namirembe Grace , Gurung Sabi , Sapkota Diplav , Bell Winnie Fay , Davis Dale , Kennedy Eileen , Neupane Shailes , Manohar Swetha , Baral Kedar 
Published: December 2016

Background: Global commitments to nutrition have supported calls for better evidence to support effective investments at national level. However, too little attention has so far been paid to the role of governance in achieving impacts. Objective: This article explores the ways by which the commitment and capabilities of policy implementers affect collaborative efforts for achieving nutrition goals. Methods: Over 1370 structured interviews were held with government and nongovernment officials over 3 years in 21 districts. Coded responses supported quantitative analysis of stakeholders’ knowledge, attitudes, and practices regarding policy implementation. Results: Stakeholder commitment was already high in 2013 when a new national policy was adopted, but capabilities were weak. Only one-third of interviewed respondents had any nutrition training. Rollout of training focusing on districts targeted for early implementation of multisector programming. This raised levels of nutrition training among interviewed respondents to 57% in 2015, which raised demand for technical information to support actions. Better understanding of the complexity of cross-sector work led to calls for higher budgets and more effective cross-sectoral collaboration. Conclusion: Nepal offers an example of effective efforts to improve nutrition governance across sectors at all levels of administration. The promotion of awareness, capacity, and new ways of working shows promise. Trainings, information sharing, and management support led to growing willingness among civil servants to engage across sectors. Structured surveys offer a viable way to track change across institutions and sectors.
The bimanual ovarian palpation examination in the Prostate, Lung, Colorectal and Ovarian cancer screening trial: Performance and complications
Authors: Doroudi Maryam , Kramer Barnett S , Pinsky Paul F 
Published: December 2016

Objective To provide evidence about the performance characteristics and consequences of bimanual ovarian palpation. Setting and methods The Prostate, Lung, Colorectal and Ovarian cancer screening trial randomized 154,900 individuals to either an intervention or control arm. Enrolled eligible participants were aged 55–74, had no history of trial cancers, and no current treatment for cancer. Intervention arm women received CA-125 tests and transvaginal ultrasound. Bimanual ovarian palpation was offered annually during the first four years of the trial. Bimanual ovarian palpation-specific sensitivity and specificity were calculated, as were rates of diagnostic procedures and resulting complications following positive bimanual ovarian palpation screens. Results A total of 20,872 women received at least one bimanual ovarian palpation, with 50,498 total bimanual ovarian palpation examinations performed. The sensitivity and specificity of bimanual ovarian palpation were 5.1% (2/39) and 99.0% (49,957/50,459), respectively; no cases were detected by bimanual ovarian palpation alone. Rates for most follow-up procedures for abnormal results in women without ovarian cancer were higher among the group with another screening test positive, except for pelvic exam, where rates were similar. No complications were reported in the bimanual ovarian palpation-only positive group. Conclusion Low sensitivity of bimanual ovarian palpation alone and in combination with other tests argue against using bimanual ovarian palpation as a screening test for ovarian cancer in asymptomatic women.
Dynamic response of a front end accessory drive system and parameter optimization for vibration reduction via a genetic algorithm
Authors: Zhu Hao , Hu Yumei , Zhu WD 
Published: December 2016

A typical engine front end accessory drive system (FEADS) is mathematically modeled through Hamilton’s principle and Newton’s second law. In this model, the belt’s flexural rigidity and pulley’s eccentricity are considered. Eccentricities of the pulleys are introduced into governing motion equations of the belt spans through the boundary conditions and then transformed to external forces acting on the belt spans. Vibration modes and natural frequencies of the FEADS are calculated by the state-space technique of the complex mode theory. Dynamic responses of the FEADS at different rotational rates of the crankshaft are calculated by solving the spatially discretized governing equations obtained by Galerkin method. The modeling and solution methods are formulated and programmed in a general purposed code. The study shows that the typical resonance and beat phenomenon happen in a certain portion of the belt spans at a certain rotational rate by the excitations of the pulley’s eccentricity. According to the modal analysis and dynamic response analysis, an optimization method based on a genetic algorithm is proposed. By comparing the vibration amplitudes of belt spans before and after optimization at different rotational rates, this optimization method is verified to be effective in reducing transverse vibrations of the belt spans.
Clinical effectiveness of bevacizumab in patients with recurrent brain tumours: A population-based evaluation
Authors: de Lemos Mário L , Markarian Adeline , Chan Esther , Schaff Kimberly , Walisser Susan 
Published: December 2016

Background Bevacizumab is an antiangiogenic agent active in patients with recurrent malignant gliomas. However, evidence for its clinical efficacy is relatively limited so that bevacizumab is approved for this indication in Canada and the United States, but not in the European Union. We reviewed the effectiveness of bevacizumab in patients with recurrent brain tumour using a large population database. Methods This was a retrospective, multicentre, study conducted at the BC Cancer Agency, a public cancer care organisation for the residents of the Canadian province of British Columbia. Cases were identified from the provincial registry and drug database. Patients were eligible if they were treated with bevacizumab with or without lomustine or etoposide for recurrent brain tumour between April 2011 and March 2014. The primary end points were progression-free survival. Secondary endpoints were overall survival and objective response rate. Results A total of 160 patients were included, with a median age of 55 years. The most common diagnosis was glioblastoma multiforme (70.6%), followed by oligodendroglioma (10.6%). Half of the patients had prior metronomic dosing of temozolomide. The median duration of therapy was 3 months. The median progression-free survival was 4.0 months and the 6-month progression-free survival was 29.4%. The median overall survival was 7 months and the 9-month and 12-month overall survival was 28.1% and 20.6%, respectively. The objective response rate was 23.1%. The most common documented reason for bevacizumab discontinuation was disease progression (66.9%), followed by toxicity (6.9%). Conclusions Bevacizumab therapy seems to be effective in delaying disease progression in patients with recurrent brain tumour, but with limited benefits on the overall survival, when used outside the clinical trial setting.
OPRM1 and COMT Gene–Gene Interaction Is Associated With Postoperative Pain and Opioid Consumption After Orthopedic Trauma
Authors: Khalil Heba , Sereika Susan M. , Dai Feng , Alexander Sheila , Conley Yvette , Gruen Gary , Meng Li , Siska Peter , Tarkin Ivan , Henker Richard 
Published: December 2016

Background: mu-opioid receptor ( OPRM1) and catechol-O-methyltransferase ( COMT) contribute to the neurotransmission pathway of pain. COMT affects mu receptor expression and density in the brain. The aim of this study was to explore the OPRM1 and COMT interaction effects on postoperative pain and opioid consumption. Methods: This cross-sectional exploratory study used genotype and clinical data from 153 postoperative patients. Using multiple regression analyses, four single-nucleotide polymorphisms of COMT (rs6269, rs4633, rs4818, and rs4680), their haplotypes, and diplotypes were considered for their interactions with A118G of OPRM1 regarding postoperative pain and opioid consumption. Results: For opioid consumption, significant interactions were found between OPRM1 A118G and COMT rs4680 ( p = .037) and between OPRM1 and COMT rs4633 ( p = .037). Patients having Met158Met of COMT rs4680 and AG/GG of OPRM1 or TT of COMT rs4633 and AG/GG of OPRM1 consumed the largest amount of opioid compared to those having other combinations. For postoperative pain, a significant interaction was found between OPRM1 and the low pain sensitivity (LPS; GCGG) haplotype of COMT ( p = .017). For patients with no copies of the LPS haplotype, AA of OPRM1 A118G was significantly associated with higher pain scores compared to the variant AG/GG. However, the opposite direction was observed for patients with at least one copy of the LPS haplotype. Conclusions: The interaction of OPRM1 with COMT may contribute to variability in postoperative pain and opioid consumption. Additional larger studies are needed to confirm findings.
Impairment of decision-making in multiple sclerosis: A neuroeconomic approach
Authors: Sepúlveda Maria , Fernández-Diez Begoña , Martínez-Lapiscina Elena H , Llufriu Sara , Sola-Valls Nuria , Zubizarreta Irati , Blanco Yolanda , Saiz Albert , Levy Dino , Glimcher Paul , Villoslada Pablo 
Published: December 2016

Objective: To assess the decision-making impairment in patients with multiple sclerosis (MS) and how they relate to other cognitive domains. Methods: We performed a cross-sectional analysis in 84 patients with MS, and 21 matched healthy controls using four tasks taken from behavioral economics: (1) risk preferences, (2) choice consistency, (3) delay of gratification, and (4) rate of learning. All tasks were conducted using real-world reward outcomes (food or money) in different real-life conditions. Participants underwent cognitive examination using the Brief Repeatable Battery-Neuropsychology. Results: Patients showed higher risk aversion (general propensity to choose the lottery was 0.51 vs 0.64, p = 0.009), a trend to choose more immediate rewards over larger but delayed rewards ( p = 0.108), and had longer reactions times ( p = 0.033). Choice consistency and learning rates were not different between groups. Progressive patients chose slower than relapsing patients. In relation to general cognitive impairments, we found correlations between impaired decision-making and impaired verbal memory ( r = 0.29, p = 0.009), visual memory ( r = −0.37, p = 0.001), and reduced processing speed ( r = −0.32, p = 0.001). Normalized gray matter volume correlated with deliberation time ( r = −0.32, p = 0.005). Conclusion: Patients with MS suffer significant decision-making impairments, even at the early stages of the disease, and may affect patients’ quality and social life.