bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyphenols from Lonicera caerulea L. berry attenuate experimental nonalcoholic steatohepatitis by inhibiting proinflammatory cytokines productions and lipid peroxidation
Authors: Wu Shusong , Yano Satoshi , Hisanaga Ayami , He Xi , He Jianhua , Sakao Kozue , Hou De‐Xing 
Published: December 2016

ScopeNonalcoholic steatohepatitis (NASH) is a common disease, which is closely associated with inflammation and oxidative stress, and Lonicera caerulea L. polyphenols (LCP) are reported to possess both antioxidant and anti‐inflammatory properties. This study aimed to investigate the protective effects and mechanisms of LCP on NASH in a high‐fat diet plus carbon tetrachloride (CCL4) induced mouse model.Methods and resultsMice were fed with high‐fat diet containing LCP (0.5–1%) or not, and then administrated with CCL4 to induce NASH. Liver sections were stained by hematoxylin–eosin stain, serum transaminases and lipids were measured by clinical analyzer, insulin was examined by ELISA, cytokines were determined by multiplex technology, and hepatic proteins were detected by Western blotting. LCP improved histopathological features of NASH with lower levels of lipid peroxidation and cytokines including granulocyte colony‐stimulating factor, IL‐3, IL‐4, macrophage inflammatory protein‐1β, IL‐6, IL‐5, keratinocyte‐derived cytokine, tumor necrosis factor‐alpha, IL‐2, IL‐1β, monocytes chemotactic protein‐1, IL‐13, IFN‐γ, IL‐10, IL‐12(p70), IL‐1α, eotaxin, granulocyte‐macrophage colony‐stimulating factor, macrophage inflammatory protein‐1α, IL‐17, and RANTES. Further molecular analysis revealed that LCP increased the expression of nuclear factor (erythroid‐derived 2)‐like 2 and manganese‐dependent superoxide dismutase, but decreased forkhead box protein O1 and heme oxygenase‐1 in the liver of NASH mice.ConclusionDietary supplementation of LCP ameliorates inflammation and lipid peroxidation by upregulating nuclear factor (erythroid‐derived 2)‐like 2 and manganese‐dependent superoxide dismutase, and downregulating forkhead box protein O1 and heme oxygenase‐1 in NASH.
Method of B0 mapping with magnitude‐based correction for bipolar two‐point Dixon cardiac MRI
Authors: Liu Junmin , Peters Dana C. , Drangova Maria 
Published: December 2016

PurposeThe conventional two‐point (2pt) Dixon technique explicitly estimates B0 map by performing phase unwrapping. When signal loss, phase singularity, artifacts, or spatially isolated regions corrupt the measured phase images, this unwrapping‐based technique will face difficulty. This work aims to improve the reliability of B0 mapping by performing unwrapping error correction.MethodTo detect the unwrapping‐caused phase errors, we determined a magnitude‐based fat/water mask and used it as reference to identify pixels being mismatched by the phase‐based mask, which was derived from the B0‐corrected phase term of the Hermitian product between echoes. Then, we corrected the afore‐determined phase error on a region‐by‐region basis. We tested the developed method with nine patients’ data, and the results were compared with a well‐established region‐growing technique.ResultsBy adding the step to correct unwrapping‐caused error, we improved the robustness of B0 mapping, resulting in better fat–water separation when compared with the conventional 2pt and the phasor‐based region‐growing techniques.ConclusionWe showed the feasibility of B0 mapping with bipolar 2pt human cardiac data. The software is freely available to the scientific community. Magn Reson Med 78:1862–1869, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Severe murine limb‐girdle muscular dystrophy type 2C pathology is diminished by FTY720 treatment
Authors: Heydemann Ahlke 
Published: December 2016

ABSTRACTIntroductionLimb‐girdle muscular dystrophy type 2C (LGMD‐2C) is caused by mutations in γ‐sarcoglycan and is a devastating, progressive, and fully lethal human muscle‐wasting disease that has no effective treatment. This study examined the efficacy of the sphingosine‐1‐phosphate receptor modulator FTY720 in treating Sgcg−/−DBA2/J, a severe mouse model of LGMD‐2C. FTY720 treatment was expected to target LGMD‐2C disease progression at 2 key positions by reducing chronic inflammation and fibrosis.MethodsThe treatment protocol was initiated at age 3 weeks and was continued with alternate‐day injections for 3 weeks.ResultsThe treatment produced significant functional benefit by plethysmography and significant reductions of membrane permeability and fibrosis. Furthermore, the protocol elevated protein levels of δ‐sarcoglycan, a dystrophin–glycoprotein family member.ConclusionThis study showed that FTY720 is an effective muscular dystrophy treatment when therapy is initiated early in the disease progression. Muscle Nerve 56: 486–494, 2017
Ischemic myopathy revealing systemic calciphylaxis
Authors: Aouizerate Jessie , Valleyrie‐Allanore Laurence , Limal Nicolas , Ayache S. Samar , Gherardi Romain K. , Audard Vincent , Jerôme Authier François 
Published: December 2016

ABSTRACTIntroductionPatients with renal failure who are being treated with dialysis frequently develop neuromuscular manifestations. Renal failure–associated calciphylaxis, also termed calcific uremic arteriolopathy (CUA), is a life‐threatening condition usually observed in patients with end‐stage renal disease on chronic dialysis or after renal transplantation.MethodsWe describe a hemodialyzed patient who presented with rapidly progressive unexplained systemic vasculopathy, muscle atrophy, and proximal weakness, that unexpectedly proved to be caused by calciphylaxis.ResultsQuadriceps muscle biopsy disclosed diffuse vascular calcific deposits on medium‐ and small‐sized vessels, characteristic of CUA. Other changes included ischemic myopathy, focal intracellular calcium accumulation within myofibers, and calcium deposits in endomysial capillaries associated with marked complement activation and C5b9 formation.ConclusionThere are only a few descriptions of muscle involvement in the context of CUA, a condition with a prognosis that depends on early diagnosis and treatment. This report underscores the usefulness of muscle biopsy in the diagnosis of systemic calciphylaxis. Muscle Nerve 56: 529–533, 2017
High‐resolution manometry in patients with idiopathic inflammatory myopathy: Elevated prevalence of esophageal involvement and differences according to autoantibody status and clinical subset
Authors: Casal‐Dominguez Maria , Pinal‐Fernandez Iago , Mego Marianela , Accarino Anna , Jubany Lluis , Azpiroz Fernando , Selva‐O'callaghan Albert 
Published: December 2016

ABSTRACTIntroductionIn this study we assessed high‐resolution manometry (HRM) findings in patients with dermatomyositis and polymyositis.MethodsFrom 2008 to 2015, we performed a cross‐sectional study of myositis patients. A survey of esophageal symptoms and HRM data were analyzed and compared among different clinical and serologic groups.ResultsTwenty‐four (45%) of the 53 patients included in the study had manometric involvement that was not correlated with any esophageal symptom (P = 0.8). Failed waves (34% vs. 0%, P = 0.004) and decreased upper esophageal sphincter pressure (50 vs. 70 mm Hg, P = 0.03) were more common in polymyositis than in dermatomyositis patients. Jackhammer esophagus was more common in anti–TIF1‐γ patients (30% vs. 9%, P = 0.04), and lower esophageal sphincter involvement (47% vs. 25%, P = 0.03) was more prevalent in patients with the antisynthetase syndrome.ConclusionsEsophageal involvement is common in myositis patients, but it correlates poorly with esophageal symptoms. Specific clinical and serologic groups have different manometric features. Muscle Nerve 56: 386–392, 2017
Muscle activation during resistance exercise at 70% and 90% 1‐repetition maximum in resistance‐trained men
Authors: Gonzalez Adam M. , Ghigiarelli Jamie J. , Sell Katie M. , Shone Edward W. , Kelly Christopher F. , Mangine Gerald T. 
Published: December 2016

ABSTRACTIntroductionMuscle activation was investigated during resistance exercise with 2 relatively high‐intensity loads.MethodsTen resistance‐trained men performed the leg press exercise to repetition failure: a set at 70% of 1‐repetition maximum (1RM) and a set at 90% of 1RM. Surface electromyography (EMG) was used to assess peak and mean muscle activation of the vastus lateralis, rectus femoris, and vastus medialis.ResultsPeak and mean EMG remained greater at 90% than 70% 1RM across all repetitions (P =  0.03 and P = 0.02, respectively). Main effects for trial were also significant for mean EMG activity of the final common repetitions (P = 0.03) favoring 90% 1RM; however, peak EMG activity was similar during the final common repetitions of the 70% and 90% 1RM sets.ConclusionsAcross all repetitions, 90% 1RM appears to produce greater muscle activation during the leg press exercise, but similar peak EMG was observed during the final common repetitions of each set. Muscle Nerve 56: 505–509, 2017
Association of Temporal Variations in Staffing With Hospital‐Acquired Pressure Injury in Military Hospitals
Authors: Patrician Patricia A. , McCarthy Mary S. , Swiger Pauline , Raju Dheeraj , Breckenridge‐Sproat Sara , Su Xiaogang , Randall Kelly H. , Loan Lori A. 
Published: December 2016

AbstractTo more precisely evaluate the effects of nurse staffing on hospital‐acquired pressure injury (HAPI) development, data on nursing care hours per patient day (NCHPPD), nursing skill mix, patient turnover (i.e., admissions, transfers, and discharges), and patient acuity were merged with patient information from pressure injury prevalence surveys that were collected annually for the Military Nursing Outcomes Database (MilNOD) project. The MilNOD included staffing and adverse events from 56 medical‐surgical, stepdown, and critical care units in 13 military hospitals over a 4‐year‐period. Data on 1,643 patients were analyzed with Cox proportional hazards models and generalized estimating equations. Staffing was not associated with pressure injuries in stepdown or critical care patients. However, among the 1,104 medical‐surgical patients, higher licensed practical nurse (LPN) nursing care hours per patient day (NCHPPD) 3 days and 1 week prior to the HAPI discovery date were associated with fewer HAPI (HR 0.27, p < .001), after controlling for patient age, Braden mobility score, and albumin level. Neither total staff number, nor RN NCHPPD, nor the proportion of staff who were RNs (RN skill mix) were associated with HAPI. These findings suggest that on military medical‐surgical units, LPNs play a major role in HAPI prevention. Although the national trend in acute care is to staff hospital units with more RNs and patient care technicians, and fewer LPNs, hospitals should reconsider LPNs as valuable members of the nursing care team. © 2016 Wiley Periodicals, Inc.
Cycles of silence: First Nations women overcoming social and historical barriers in supportive cancer care
Authors: Hammond Chad , Thomas Roanne , Gifford Wendy , Poudrier Jennifer , Hamilton Ryan , Brooks Carolyn , Morrison Tricia , Scott Tracy , Warner Doris 
Published: December 2016

AbstractBackgroundFirst Nations people with cancer in Canada confront several critical inequities in physical and psychosocial domains. First Nations women are at a particular disadvantage as they are disproportionately affected by social determinants of health, but how they navigate these challenges within their communities is poorly understood.ObjectiveOur study explores survivorship experiences of First Nations women with cancer and their caregivers. Drawing from a larger data set on survivorship, we identify several major barriers to cancer communication and support in First Nations communities.MethodsOur team conducted a participatory, arts‐based study using several data collection methods (interviews, sharing sessions, photovoice, and other creative activities) with 43 participants (24 cancer survivors and 19 caregivers) from four First Nations communities in Canada.ResultsTwo major themes have emerged out of our data analyses: (1) suffering without support leads to cycles of silence and (2) community‐based supports can disrupt these cycles. We identified several social, historical, and institutional barriers to speaking about cancer and finding/providing support; however, communities met the challenge of silence through voluntary and unsolicited provision of support.ConclusionsWidespread silence around cancer reflects both the limited access First Nations people have to formal, supportive programs and services, as well as the creative ways they provide emotional, social, and financial support within their informal networks. Beyond the support of their communities, they also required institutional provision of care that is culturally safe, addressing the colonial impacts on cancer communication and the disproportionate burdens of disease in First Nations communities.
Performance comparison of electrospray ionization and atmospheric pressure chemical ionization in untargeted and targeted liquid chromatography/mass spectrometry based metabolomics analysis of grapeberry metabolites
Authors: Commisso Mauro , Anesi Andrea , Dal Santo Silvia , Guzzo Flavia 
Published: December 2016

RationaleElectrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) are both used to generate ions for the analysis of metabolites by liquid chromatography/mass spectrometry (LC/MS). We compared the performance of these methods for the analysis of Corvina grapevine berry methanolic extracts, which are complex mixtures of diverse metabolites.MethodsCorvina berries representing three ripening stages (veraison, early‐ripening and full‐ripening) were collected during two growing seasons, powdered and extracted with methanol. Untargeted metabolomic analysis was carried out by LC/ESI‐MS and LC/APCI‐MS. Processed data files were assembled into a data matrix for multivariate statistical analysis. The limits of detection (LODs), limits of quantification (LOQs), linear ranges, and matrix effects were investigated for strongly polar metabolites such as sucrose and tartaric acid and for moderately polar metabolites such as caftaric acid, epicatechin and quercetin 3‐O‐glucoside.ResultsMultivariate statistical analysis of the 608 features revealed that APCI was particularly suitable for the ionization of strongly polar metabolites such as sugars and organic acids, whereas ESI was more suitable for moderately polar metabolites such as flavanols, flavones and both glycosylated and acylated anthocyanins. APCI generated more fragment ions whereas ESI generated more adducts. ESI achieved lower LODs and LOQs for sucrose and tartaric acid but featured narrower linear ranges and greater matrix effects.ConclusionsESI and APCI are not complementary ion sources. Indeed, ESI can be exploited to analyze moderately polar metabolites, whereas APCI can be used to investigate weakly polar/non‐polar metabolites and, as demonstrated by our results, also strongly polar metabolites. ESI and APCI can be used in parallel, exploiting their strengths to cover the plant metabolome more broadly than either method alone. Copyright © 2016 John Wiley & Sons, Ltd.
MREA: a minimum resource expenditure node capture attack in wireless sensor networks
Authors: Lin Chi , Qiu Tie , Obaidat Mohammad S. , Yu Chang Wu , Yao Lin , Wu Guowei 
Published: December 2016

AbstractBecause of the stochastic key pre‐distribution and complicated network topology, designing an energy‐efficient node capture attack algorithm is of great challenge. Although many algorithms have been proposed for node capture attack, previous methods lack of concerning minimizing resource expenditure in modeling attacking behavior. In this paper, we propose a novel way of modeling the node capture attack. First, we transform the problem into a set covering problem with a shortest Hamiltonian cycle problem, which has been shown to be NP‐hard. Consequently, we also develop a heuristic called minimum resource expenditure node capture attack (MREA) to maximize destructiveness while minimizing resource expenditure. Moreover, extensive simulations are conducted to show the performance of MREA. Simulation results show that MREA outperforms other algorithms in reducing the attack rounds and saving resource expenditure. Copyright © 2016 John Wiley & Sons, Ltd.
Customized vs population‐based growth charts to identify neonates at risk of adverse outcome: systematic review and Bayesian meta‐analysis of observational studies
Authors: Chiossi G. , Pedroza C. , Costantine M. M. , Truong V. T. T. , Gargano G. , Saade G. R. 
Published: December 2016

ABSTRACTObjectiveTo compare the effectiveness of customized vs population‐based growth charts for the prediction of adverse pregnancy outcomes.MethodsMEDLINE, ClinicalTrials.gov and The Cochrane Library were searched up to 31 May 2016 to identify interventional and observational studies comparing adverse outcomes among large‐ (LGA) and small‐ (SGA) for‐gestational‐age neonates, when classified according to customized vs population‐based growth charts. Perinatal mortality and admission to the neonatal intensive care unit (NICU) of both SGA and LGA neonates, intrauterine fetal demise (IUFD) and neonatal mortality of SGA neonates, and neonatal shoulder dystocia and hypoglycemia as well as maternal third‐ and fourth‐degree perineal lacerations in LGA pregnancies were evaluated.ResultsThe electronic search identified 237 records that were examined based on title and abstract, of which 27 full‐text articles were examined for eligibility. After excluding seven articles, 20 observational studies were included in a Bayesian meta‐analysis. Neonates classified as SGA according to customized growth charts had higher risks of IUFD (odds ratio (OR), 7.8 (95% CI, 4.2–12.3)), neonatal death (OR, 3.5 (95% CI, 1.1–8.0)), perinatal death (OR, 5.8 (95% CI, 3.8–7.8)) and NICU admission (OR, 3.6 (95% CI, 2.0–5.5)) than did non‐SGA cases. Neonates classified as SGA according to population‐based growth charts also had increased risk for adverse outcomes, albeit the point estimates of the pooled ORs were smaller: IUFD (OR, 3.3 (95% CI, 1.9–5.0)), neonatal death (OR, 2.9 (95% CI, 1.2–4.5)), perinatal death (OR, 4.0 (95% CI, 2.8–5.1)) and NICU admission (OR, 2.4 (95% CI, 1.7–3.2)). For LGA vs non‐LGA, there were no differences in pooled ORs for perinatal death, NICU admission, hypoglycemia and maternal third‐ and fourth‐degree perineal lacerations when classified according to either the customized or the population‐based approach. In contrast, both approaches indicated that LGA neonates are at increased risk for shoulder dystocia than are non‐LGA ones (OR, 7.4 (95% CI, 4.9–9.8) using customized charts; OR, 8.0 (95% CI, 5.3–10.1) using population‐based charts).ConclusionsBoth customized and population‐based growth charts can identify SGA neonates at risk for adverse outcomes. Although the point estimates of the pooled ORs may differ for some outcomes, the overlapping CIs and lack of direct comparisons prevent conclusions from being drawn on the superiority of one method. Future clinical trials should compare directly the two approaches in the management of fetuses of abnormal size. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
Future liquefied natural gas business structure: a review and comparison of oil and liquefied natural gas sectors
Authors: Nikhalat‐Jahromi Hamed , Fontes Dalila B.M.M. , Cochrane Robert A. 
Published: December 2016

The liquefied natural gas (LNG) trade provides the means of trading gas globally and represents about 10% of the gas trade. The forecasts show the LNG business will grow, over the next 20 years, at about twice the rate of the whole gas trade. Although the current state of LNG trade is well studied, the literature on the future business structure of it is limited and conflictual. This work considers the future LNG business structure by comparing the development trajectories of the oil and LNG sectors. In addition, it assesses the conclusions drawn by researchers against this background and the current pattern of change in the industry. The comparison involves three stages: (1) trade flows—oil and LNG trade flows are very similar, mainly due to the common distribution of the oil and gas reserves. (2) Supply chain configuration—the international trade for both fuels is tanker based thus allowing for a similar market responsive trade policy, i.e., real‐time destination selection (spot sale) at a global scale. (3) Institutional developments—the current transparent and competitive global oil trade, with prices dominated by physical and paper markets, was driven previously by long‐term contracts, in the same manner as the current LNG business. This analysis, together with transaction cost economics, supports the argument that, in future, LNG spot trade will increase and give rise to a competitive and globally
unified LNG market. Furthermore, LNG pricing will become transparent and would be dominated by physical and paper markets benchmark prices. WIREs Energy Environ 2017, 6:e240. doi: 10.1002/wene.240This article is categorized under:

Energy Policy and Planning > Economics and Policy
Energy Policy and Planning > Systems and Infrastructure
Energy and Development > Economics and Policy
LJM716 in Japanese patients with head and neck squamous cell carcinoma or HER2-overexpressing breast or gastric cancer
Authors: Takahashi Shunji , Kobayashi Takayuki , Tomomatsu Junichi , Ito Yoshinori , Oda Hisanobu , Kajitani Tatsuhiro , Kakizume Tomoyuki , Tajima Takeshi , Takeuchi Hiromi , Maacke Heiko , Esaki Taito 
Published: December 2016

Abstract
Purpose
Human epidermal growth factor receptor 3 (HER3) has been identified as an important component of many receptor tyrosine kinase-driven cancers. LJM716 is a human IgG monoclonal antibody that binds HER3, trapping it in an inactive conformation. In this study, a phase I dose escalation was performed with a primary objective to establish the maximum tolerated dose and/or the recommended dose of LJM716 in Japanese patients with selected advanced solid tumors. Secondary objectives included the evaluation of the safety and tolerability, preliminary antitumor activity, and pharmacokinetics of LJM716 in Japanese patients.

Methods
LJM716 was administered intravenously at doses of 10, 20, or 40 mg/kg once weekly, in 28-day cycles, to 12 patients with HER2-amplified breast cancer or gastric cancer, or with esophageal squamous cell carcinoma or squamous cell carcinoma of the head and neck, regardless of HER2 status.

Results
The maximum tolerated dose was not reached, and the recommended dose was established at 40 mg/kg. No dose-limiting toxicities were observed in the first cycle. The most frequently reported adverse events were diarrhea, fatigue, stomatitis, pyrexia, and paronychia. One unconfirmed partial response was observed in a patient with breast cancer, and 50% of the patients achieved stable disease as the best overall response. Exposure increased with ascending dose, and half-life was estimated to be 11–14 days. No anti-LJM716 antibodies were detected.

Conclusions
LJM716 was well tolerated in Japanese patients, and a degree of tumor shrinkage was observed.

Clinical trial information
ClinicalTrials.gov NCT01911936.