bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concomitant alterations of metabolic parameters, cardiovascular risk factors and altered cortisol secretion in patients with adrenal incidentalomas during prolonged follow‐up
Authors: Papanastasiou Labrini , Alexandraki Krystallenia Ι. , Androulakis Ioannis I. , Fountoulakis Stelios , Kounadi Theodora , Markou Athina , Tsiavos Vaios , Samara Christianna , Papaioannou Theodoros G. , Piaditis George , Kaltsas Gregory 
Published: December 2016

SummaryObjectiveAdrenal incidentalomas (AI) are associated with metabolic and hormonal abnormalities, most commonly autonomous cortisol secretion (ACS). Data regarding alterations of insulin resistance (IR) and ACS after prolonged follow‐up are limited. We investigated the evolution of IR, cortisol secretion and ACS development in patients with AI during prolonged follow‐up.DesignProspective study in a tertiary hospital.Patients and measurementsSeventy‐one patients with AI [51 nonfunctioning (NFAI) and 20 ACS] and 5·54 ± 1·7 years follow‐up underwent testing for ACS and oral glucose tolerance test to determine IR indices and adrenal imaging.ResultsAt follow‐up, 16/51 (31%) NFAI patients converted to ACS, while two with previous ACS reverted to NFAI; 21% (7/33) of patients who did not covert to ACS exhibited high urinary‐free cortisol (H‐UFC) levels. All AI patients developed deterioration of IR irrespective of their cortisol secretory status. Eight patients developed newly diagnosed type 2 diabetes (9·8% NFAI and 15% ACS, respectively) and 14 IR (17·6% NFAI and 25% ACS, respectively). Adenoma size increased from 2·1 ± 0·8 to 2·3 ± 0·8 cm, whereas IR correlated with postdexamethasone cortisol level and adenoma size increase. IR showed an incremental continuum trend from normal UFC (Ν‐UFC), to H‐UFC, C‐ACS and ACS patients.ConclusionsNew‐onset ACS developed in 31% patients with NFAI, whereas 21% of NFAI patients had H‐UFC levels. All AI patients as a group and the subgroups of N‐UFC, H‐UFC, C‐ACS and ACS patients developed deterioration of metabolic parameters during follow‐up that was more prominent in ACS patients.
‘En face’ ex vivo reflectance confocal microscopy to help the surgery of basal cell carcinoma of the eyelid
Authors: Espinasse Marine , Cinotti Elisa , Grivet Damien , Labeille Bruno , Prade Virginie , Douchet Catherine , Cambazard Frédéric , Thuret Gilles , Gain Philippe , Perrot Jean Luc 
Published: December 2016

AbstractBackgroundEx vivo confocal microscopy is a recent imaging technique for the perioperative control of skin tumour margins. Up to date, it has been used in the fluorescence mode and with vertical sections of the specimen margins. The aim of this study was to evaluate its use in the reflectance mode and with a horizontal (‘en face’) scanning of the surgical specimen in a series of basal cell carcinoma of the eyelid.DesignProspective consecutive cohort study was performed at the University Hospital of Saint‐Etienne, France.ParticipantsForty‐one patients with 42 basal cell carcinoma of the eyelid participated in this study.MethodsBasal cell carcinomas were excised with a 2‐mm‐wide clinically safe margin. The surgical specimens were analysed under ex vivo confocal microscopy in the reflectance mode and with an en face scanning in order to control at a microscopic level if the margins were free from tumour invasion. Histopathogical examination was later performed in order to compare the results.Main Outcome MeasuresSensitivity and specificity of ex vivo confocal microscopy for the presence of tumour‐free margins.ResultsEx vivo confocal microscopy results were consistent with histopathology in all cases (tumour‐free margins in 40 out of 42 samples; sensitivity and specificity of 100%).ConclusionsEx vivo confocal microscopy in the reflectance mode with an ‘en face’ scanning can control tumour margins of eyelid basal cell carcinomas and optimize their surgical management. This procedure has the advantage on the fluorescent mode of not needing any contrast agent to examine the samples.
Dental Implant Survival and Complication Rate over 2 Years for Individuals with Poorly Controlled Type 2 Diabetes Mellitus
Authors: Eskow Caroline C. , Oates Thomas W. 
Published: December 2016

AbstractBackgroundEmerging evidence suggests that implant therapy may be a viable option for diabetic individuals with elevated glycemic levels.PurposeThe purpose of this 2 year observational study was to evaluate survival and clinical complications of dental implants following placement in type 2 diabetes individuals having poor glycemic control.Materials and MethodsAdult participants (n = 24) with poorly controlled type 2 diabetes (8.0% ≤ HbA1c ≤ 12.0%) received two or more transgingival dental implants. Survival was evaluated after 1 (23 participants, 72 implants) and 2 (20 participants, 59 implants) years. Clinical complications were evaluated in 18 participants (52 implants) after 21‐34 months. Relationships between complications and stratified HbA1c levels were assessed using Pearson's correlation test.ResultsSurvival rates were 98.6% (71/72 implants) after 1 year and 96.6% (57/59 implants) after 2 years. Complications were identified in 29% of participants with peri‐implant mucositis, the most common event. Complications correlated directly with number of implants across HbA1c strata (0.42, R2 = 0.66). There was no correlation between HbA1c and the occurrences of complications or mucositis.ConclusionsThis 2‐year evaluation supports the broader application of implant therapy in type 2 diabetes individuals with poor glycemic control in demonstrating high survival rates with limited complications.
The Impact of Local Ethanol Production on the Corn Basis in Ontario
Authors: Wu Zhige , Weersink Alfons , Maynard Alex , Hailu Getu , Vyn Richard 
Published: December 2016

This paper investigates the factors affecting the corn basis in Ontario with particular emphasis on the effect of ethanol production given the projected detrimental effect its expansion could have on the red meat sector. We estimate a location‐specific and panel vector error correction models (VECM) for seven elevators in Ontario from 2006 to 2013. We find a long‐run equilibrium relationship exists between the basis and factors affecting local supply and demand including ethanol capacity and that the direction of causality is from these factors to changes in corn price. A one‐time increase in ethanol capacity of 100 million liters is projected to increase the basis by approximately 30 cents per bushel within two years. However, the impact is insignificant for elevators located in the livestock‐intensive regions of the province. The demand for corn as livestock feed is a determinant of the local corn price for all elevators. The decline in the number of hogs and beef cattle along with the 50% increase in corn supply have resulted in the observed decline in the local corn price despite the significant increase in demand from ethanol.L'impact de la production locale d′éthanol sur le prix de base du maïs en Ontario Cet article cherche à comprendre les facteurs ayant un effet sur le prix de base du maïs en Ontario, en particulier sur les effets de la production d′éthanol étant donné les effets négatifs attendus sur le secteur de la viande rouge causés par son expansion. Nous estimons des modèles vectoriels à correction d'erreurs (MVCE) à emplacements précis et panel entre 2006 et 2013, pour 7 silos‐élévateurs en Ontario. Nous constatons une relation d′équilibre à long terme entre le prix de base et les facteurs ayant un effet sur l'offre et la demande locale incluant la capacité pour l′éthanol. Nous constatons aussi que le sens de la causalité passe de ces facteurs aux changements du prix du maïs. L'on s'attend à voir une augmentation d'environ 30 cents du prix de base du boisseau suivant l'augmentation unique de 100 millions de litres de la capacité d′éthanol. Par contre, l'impact est négligeable pour les silos‐élévateurs situés dans les régions d′élevage intensif de la province. La demande pour le maïs comme aliment pour le bétail est un facteur déterminant du prix local du maïs pour tous les silos‐élévateurs. Le déclin du porc et des bovins ainsi que l'augmentation de 50 % de l'offre de maïs ont mené à la diminution notée du prix du maïs local malgré l'augmentation significative de la demande pour l′éthanol.
Assessing the shelf life of cost‐efficient conservation plans for species at risk across gradients of agricultural land use
Authors: Robillard Cassandra M. , Kerr Jeremy T. 
Published: December 2016

AbstractHigh costs of land in agricultural regions warrant spatial prioritization approaches to conservation that explicitly consider land prices to produce protected‐area networks that accomplish targets efficiently. However, land‐use changes in such regions and delays between plan design and implementation may render optimized plans obsolete before implementation occurs. To measure the shelf life of cost‐efficient conservation plans, we simulated a land‐acquisition and restoration initiative aimed at conserving species at risk in Canada's farmlands. We accounted for observed changes in land‐acquisition costs and in agricultural intensity based on censuses of agriculture taken from 1986 to 2011. For each year of data, we mapped costs and areas of conservation priority designated using Marxan. We compared plans to test for changes through time in the arrangement of high‐priority sites and in the total cost of each plan. For acquisition costs, we measured the savings from accounting for prices during site selection. Land‐acquisition costs and land‐use intensity generally rose over time independent of inflation (24–78%), although rates of change were heterogeneous through space and decreased in some areas. Accounting for spatial variation in land price lowered the cost of conservation plans by 1.73–13.9%, decreased the range of costs by 19–82%, and created unique solutions from which to choose. Despite the rise in plan costs over time, the high conservation priority of particular areas remained consistent. Delaying conservation in these critical areas may compromise what optimized conservation plans can achieve. In the case of Canadian farmland, rapid conservation action is cost‐effective, even with moderate levels of uncertainty in how to implement restoration goals.
Acantholytic invasive squamous cell carcinoma: tumor diameter, invasion depth, grade of differentiation, surgical margins, perineural invasion, recurrence and death rate
Authors: Pyne J. H. , Myint E. , Barr E. M. , Clark S. P. , David M. , Na R. 
Published: December 2016

BackgroundSquamous cell carcinoma (SCC) may present with or without the feature of acantholysis.MethodsInvestigate invasive acantholytic SCC by microscopic maximum tumor surface diameter, depth of invasion, grade of differentiation, perineural invasion (PNI) and percentage of acantholysis. Assess recurrence following excision.ResultsA total of 1658 consecutive invasive SCC cases were examined, comprising 4.9% acantholytic SCC. Median tumor microscopic maximum diameter was 8 mm for acantholytic SCC and 7.3 mm for non‐acantholytic SCC. Median tumor invasion depth was 1.0 mm for acantholytic SCC and 1.5 mm for non‐acantholytic SCC. Well, moderate and poor differentiation were not significantly different between acantholytic SCC and non‐acantholytic SCC. One PNI case was found in 82 acantholytic SCC cases. A total of 77 acantholytic SCC cases were followed up over a median 25 months finding histologic proven recurrence at three acantholytic SCC excision sites.ConclusionsAcantholytic SCC were more likely to be located on head sites with less median depth than non‐acantholytic SCC. Increasing percentage of acantholysis within acantholytic SCC was not associated with a shift towards poor differentiation. Histologic margins of 1.2 mm may adequately excise small acantholytic SCC. No recorded deaths, low PNI and low recurrence rates suggests acantholytic SCC is low‐risk.
Kompressionstherapie – Versorgungspraxis: Informationsstand von Patienten mit Ulcus cruris venosum
Authors: Protz Kerstin , Heyer Kristina , Dissemond Joachim , Temme Barbara , Münter Karl‐Christian , Verheyen‐Cronau Ida , Klose Katharina , Hampel‐Kalthoff Carsten , Augustin Matthias 
Published: December 2016

ZusammenfassungHintergrund und ZieleEine Säule der kausalen Therapie bei Patienten mit Ulcus cruris venosum ist die Kompressionstherapie. Sie unterstützt die Abheilung, reduziert Schmerzen und Rezidive und steigert die Lebensqualität. Bislang existieren kaum wissenschaftliche Daten zu dem Versorgungsstand und fachspezifischem Wissen von Patienten mit Ulcus cruris venosum.Patienten und MethodikStandardisierte Fragebögen wurden bundesweit in 55 Pflegediensten, 32 Arztpraxen, vier Wundzentren und ‐sprechstunden sowie einem Pflegetherapiestützpunkt von Patienten mit Ulcus cruris venosum bei Erstvorstellung anonym ausgefüllt.ErgebnisseInsgesamt nahmen 177 Patienten (Durchschnittsalter 69,4 Jahre; 75,1 % Frauen) teil. Ein florides Ulcus cruris venosum bestand im Mittel 17 Monate. 31,1 % hatten keine Kompressionstherapie, 40,1 % Binden und 28,8 % Strümpfe. Bei der Bestrumpfung hatten 13,7 % Kompressionsklasse III, 64,7 % Kompressionsklasse II und 19,6 % Kompressionsklasse I. 70,6 % legten die Strümpfe nach dem Aufstehen an, 21,1 % trugen sie Tag und Nacht. 39,2 % bereiteten die Strümpfe Beschwerden. Lediglich 11,7 % hatten eine An‐ und Ausziehhilfe. Die Binden wurden im Mittel 40,7 Wochen getragen und bei 69 % nicht unterpolstert. Bei 2,8 % wurde der Knöchel‐ und Waden‐Umfang zur Erfolgskontrolle gemessen. Venensport machten 45,9 %.SchlussfolgerungenEin Drittel hatte keine Kompressionsversorgung, obwohl diese eine Basismaßnahme der Therapie des Ulcus cruris venosum ist. Zudem ist deren korrekte Auswahl und Anwendung angesichts der langen Bestandsdauer der Ulzerationen zu hinterfragen. Weiterführende Fachkenntnisse bei Anwendern und Verordnern sowie Patientenschulungen sind erforderlich.
Verantwortlicher Umgang mit Antibiotika: Notwendigkeit der Antibiotikareduktion in der Aknetherapie
Authors: Gollnick Harald P. M. , Buer Jan , Beissert Stefan , Sunderkätter Cord 
Published: December 2016

ZusammenfassungDer übermäßige oder unkritische weltweite Einsatz von Antibiotika in der Medizin hat die Ausbreitung von Antibiotikaresistenzen beschleunigt. In einigen Bereichen sind viele Antibiotika bei bakteriellen Infektionen, die zuvor noch gut auf antibakterielle Wirkstoffe reagierten, mittlerweile wirkungslos geworden. Dermatologen/Venerologen setzten orale und topische Antibiotika bei der Behandlung von Acne vulgaris routinemäßig ein, obwohl Akne weder eine infektiöse Erkrankung ist noch alleine durch das Propionibacterium getriggert wird. Vielmehr ist sie eine komplexe, chronische entzündliche Hauterkrankung, die durch verschiedene pathogenetische Faktoren wie follikuläre Hyperkeratose, erhöhter Sebumproduktion, bakterielle Proliferation und Entzündung zustande kommt. Folglich sollte eine erfolgreiche Therapie auf die Bekämpfung verschiedener pathogenetischer Faktoren und nicht nur auf die von Propionibacterium acnes abzielen. Daher wurden topische Retinoide und Benzoylperoxid als Mittel der ersten Wahl definiert. Monotherapien mit lokalen Antibiotika sollten insgesamt vermieden werden. Systemische Antibiotika der Tetrazyklin‐Gruppe haben bei bestimmen Krankheitsstadien ihren Sinn, ihre Wirkung könnte aber eher auf der antientzündlichen als auf der antibiotischen Reaktion beruhen. Gesundheitsbehörden ermahnen alle Gesundheitsdienstleister, den Einsatz von Antibiotika einzuschränken. Das Nutzen‐Risiko‐Verhältnis muss bei der Entscheidung für oder gegen eine antibiotische Therapie bei einem einzelnen Patienten immer auch in Bezug auf das öffentliche Interesse am Erhalt der Wirksamkeit von Antibiotika abgewogen werden. Im Folgenden werden das aktuelle Krankheitskonzept zu Acne vulgaris und die sich daraus ableitenden Konsequenzen für den Einsatz von Antibiotika vorgestellt.
Management of veno‐occlusive disease: the multidisciplinary approach to care
Authors: Wallhult Elisabeth , Kenyon Michelle , Liptrott Sarah , Mank Arno , Ní Chonghaile Mairéad , Babic Aleksandra , Bijkerk Jacobine , Bompoint Caroline , Corbacioglu Selim , de Weijer Roel , Fink Claudia , Marktel Sarah , Soni Vivek , Sprenger Sarah , Arjona Eugenia Trigoso , Mohty Mohamad 
Published: December 2016

AbstractAlthough it is considered a relatively rare disorder, veno‐occlusive disease (VOD) is one of the main causes of overall, non‐relapse mortality associated with haematopoietic stem cell transplantation (HSCT). This article, based on the consensus opinion of haemato‐oncology nurses, haemato‐oncologists and pharmacists from both adult and paediatric services at the VOD International Multi‐Disciplinary Advisory Board at the European Society for Blood and Marrow Transplantation (EBMT) meeting, Istanbul, 2015, aims to explore the multidisciplinary approach to care for the management of VOD, with an emphasis on current challenges in this area. The careful monitoring of HSCT patients allows early detection of the symptoms associated with VOD and timely treatment, ultimately improving patient outcomes. As part of a multidisciplinary team, nurses have an essential role to play, from pretransplant assessment to medical management and overall care of the patient. Physicians and pharmacists have a responsibility to facilitate education and training so that nurses can work effectively within that team.
Binocular function during unequal monocular input
Authors: Kim Taekjun , Freeman Ralph D. 
Published: December 2016

AbstractThe fine task of stereoscopic depth discrimination in human subjects requires a functional binocular system. Behavioral investigations show that relatively small binocular abnormalities can diminish stereoscopic acuity. Clinical evaluations are consistent with this observation. Neurons in visual cortex represent the first stage of processing of the binocular system. Cells at this level are generally acutely sensitive to differences in relative depth. However, an apparent paradox in previous work demonstrates that tuning for binocular disparities remains relatively constant even when large contrast differences are imposed between left and right eye stimuli. This implies a range of neural binocular function that is at odds with behavioral findings. To explore this inconsistency, we have conducted psychophysical tests by which human subjects view vertical sinusoidal gratings drifting in opposite directions to left and right eyes. If the opposite drifting gratings are integrated in visual cortex, as wave theory and neurophysiological data predict, the subjects should perceive a fused stationary grating that is counter‐phasing in place. However, this behavioral combination may not occur if there are differences in contrast and therefore signal strength between left and right eye stimuli. As expected for the control condition, our results show fused counter‐phase perception for equal inter‐ocular grating contrasts. Our experimental tests show a striking retention of counter‐phase perception even for relatively large differences in inter‐ocular contrast. This finding demonstrates that binocular integration, although relatively coarse, can occur during substantial differences in left and right eye signal strength.
Magnetic resonance imaging‐guided injection of platelet‐rich plasma for treatment of an insertional core lesion of the deep digital flexor tendon within the foot of a horse
Authors: Marcatili M. , Marshall J. , Voute L. 
Published: December 2016

SummaryDefinitive diagnosis of a deep digital flexor tendon insertional lesion within the right fore foot was made by magnetic resonance imaging (MRI) examination and the lesion subsequently treated by injection with platelet‐rich plasma. MRI was used to guide positioning of the needle to achieve highly accurate injection. The volume injected was found to approximate the calculated lesion volume. On the basis of experience with this case, MRI‐guided injection of insertional deep digital flexor tendon lesions of the foot of horses under general anaesthesia is practicable. This technique is likely to be more accurate than the other techniques described (computed tomography, ultrasonography) and carries no risk of exposure to radiation (radiography).
Non‐invasive metabolic imaging of melanoma progression
Authors: Pastore Michael N. , Studier Hauke , Bonder Claudine S. , Roberts Michael S. 
Published: December 2016

AbstractSkin cancer is associated with abnormal cellular metabolism which if identified early introduces the possibility of intervention to prevent its progress to a deadly metastatic stage. This study combines multiphoton microscopy with fluorescence lifetime imaging (FLIM) using a syngeneic melanoma mouse model, to detect changes in metabolic state of single epidermal cells as a metabolic marker to monitor the progress of tumor growth. This method utilizes imaging of the ratio of the amounts of the free and protein‐bound forms of the intracellular autofluorescent metabolic co‐enzyme nicotinamide adenine dinucleotide (NADH). Here, we investigate the impact of the primary tumor lesion on the epidermal layers at three different growth stages of melanoma lesion compared to normal skin as a control. We showed a significant increase in the free‐to‐bound NADH ratio with the growth of the solid melanoma tumor, while concurrently the short and the long lifetime components of NADH remained constant. These results demonstrate the ability of FLIM for rapid, non‐invasive and sensitive assessment of melanoma progression revealing its potential as a diagnostic tool for melanoma detection and as an aid for melanoma staging.
Expression of claudin‐11 by tumor cells in cutaneous squamous cell carcinoma is dependent on the activity of p38δ
Authors: Nissinen Liisa , Siljamäki Elina , Riihilä Pilvi , Piipponen Minna , Farshchian Mehdi , Kivisaari Atte , Kallajoki Markku , Raiko Laura , Peltonen Juha , Peltonen Sirkku , Kähäri Veli‐Matti 
Published: December 2016

AbstractThe incidence of cutaneous squamous cell carcinoma (cSCC) is rapidly increasing, and the prognosis of patients with metastatic disease is poor. There is an emerging need to identify molecular markers for predicting aggressive behaviour of cSCC. Here, we have examined the role of tight junction (TJ) components in the progression of cSCC. The expression pattern of mRNAs for TJ components was determined with RNA sequencing and oligonucleotide array‐based expression analysis from cSCC cell lines (n=8) and normal human epidermal keratinocytes (NHEK, n=5). The expression of CLDN11 was specifically elevated in primary cSCC cell lines (n=5), but low or absent in metastatic cSCC cell lines (n=3) and NHEKs. Claudin‐11 was detected in cell‐cell contacts of primary cSCC cells in culture by indirect immunofluorescence analysis. Analysis of a large panel of tissue samples from sporadic UV‐induced cSCC (n=65), cSCC in situ (n=56), actinic keratoses (n=31), seborrhoeic keratoses (n=7) and normal skin (n=16) by immunohistochemistry showed specific staining for claudin‐11 in intercellular junctions of keratinizing tumor cells in well and moderately differentiated cSCCs, whereas no staining for claudin‐11 was detected in poorly differentiated tumors. The expression of claudin‐11 in cSCC cells was dependent on the activity of p38δ MAPK and knock‐down of claudin‐11 enhanced cSCC cell invasion. These findings provide evidence for the role of claudin‐11 in regulation of cSCC invasion and suggest loss of claudin‐11 expression in tumor cells as a biomarker for advanced stage of cSCC.