bluuebunny/crossref_metadata_2025_split huggingface dataset:
De keuze tussen strafrechtelijke en bestuursrechtelijke sanctionering en het criterium van de ernstige gedraging
Authors: van der Vorm Benny 
Published: August 2017

The choice between criminal and administrative sanctioning and the criterium of serious conduct
In the near future, the legislator will decide on the criteria to be applied to make a choice between the administrative and the criminal justice system. It is a possibility that the legislator will depart from the so-called ‘open context’ and the ‘confined context’. In his Farewell Speech, Rogier pleaded that the severity of behavior should be the criterion to the applied. When behavior can be qualified as ‘serious’ a criminal procedure should take place and if the behavior is ‘less serious’ the administrative procedure has to be chosen.
Hoe werkt vroegsignalering door lokale jongerenwerkers in de strijd tegen terrorisme?
Authors: van de Weert Annemarie , Eijkman Quirine 
Published: August 2017

How does early signaling by local youth workers affect the fight against terrorism?
This article analyses whether the local youth worker can operate on the intersection of social welfare and signalling of extremism. Although it is a rare phenomenon, there is a clear message from the government to watch out for the first signs of deviant behavior and unacceptable behavior. However, shouldn’t we ask ourselves whether youth workers are adequately equipped at local level to signal threat? The qualitative results show that in daily practice there is a lack of clear standards which make terminology for social professionals not easily distinguished. In addition their opinion depends largely on their own intuition regarding the issues. This can create side effects which form a risk that the local terrorism policy does not have the intended effect.
Klachtrecht in de care-sector: miniproces of goed gesprek?
Authors: Tiems Simona 
Published: August 2017

Complaint or dispute resolution in Dutch health care: a constructive dialogue or a mini trial
Care providers establish often long term relationships with their clients. It is of paramount importance that the threshold for a complaint or dispute resolution is preferably low. Ideally this is not a ‘mini-trial’ in which care provider and client are opposed against each other, but a constructive dialogue at a round table guided by a skillful complaints officer. This is what has been introduced by the Healthcare Quality, Complaints and Disputes Act (the Wkkgz).The new complaint system introduced with the Wkkgz applies to care covered by the Chronic Care Act (WLZ), the Healthcare Insurance Act (ZVW) and optionally can also apply to care based on the Social Support Act (WMO 2015).In my opinion it is a missed opportunity that the legislator has not introduced a similar complaint procedure in the Youth Act, but instead has chosen the ‘mini-trial’ option here. Moreover, it is also confusing for care providers and clients to follow different complaints systems next to each other.Finally, in psychiatric care where decisions of care providers can interfere with the right to self-determination there is a separate complaint procedure with a role for the Family Court. For all other run-of-the mill issues also in the psychiatric care the Wkkgz complaint procedure applies.
Lionfish (Pterois spp.) invade the upper-bathyal zone in the western Atlantic
Authors: Gress Erika , Andradi-Brown Dominic A. , Woodall Lucy , Schofield Pamela J. , Stanley Karl , Rogers Alex D. 
Published: August 2017

Non-native lionfish have been recorded throughout the western Atlantic on both shallow and mesophotic reefs, where they have been linked to declines in reef health. In this study we report the first lionfish observations from the deep sea (>200 m) in Bermuda and Roatan, Honduras, with lionfish observed to a maximum depth of 304 m off the Bermuda platform, and 250 m off West End, Roatan. Placed in the context of other deeper lionfish observations and records, our results imply that lionfish may be present in the 200–300 m depth range of the upper-bathyal zone across many locations in the western Atlantic, but currently are under-sampled compared to shallow habitats. We highlight the need for considering deep-sea lionfish populations in future invasive lionfish management.
Assessment of the toxicity of sediment and seawater polluted by the Prestige fuel spill using bioassays with clams (Venerupis pullastra, Tappes decussatus and Venerupis rhomboideus) and the microalga Skeletonema costatum
Authors: Mariño-Balsa JC , Pérez P , Estévez-Blanco P , Saco-Álvarez L , Fernández E , Beiras R 
Published: August 2017

In this study we present the early monitoring of the pollution caused by the accident of the Prestige tanker off the Galician coast. To evaluate the toxicity of sediment and water exposed to fuel, three kinds of bioassays were carried out using juvenile clams, clam embryos and microalgae. Firstly, the burrowing behaviour of Venerupis pullastra and Tappes decussatus in the sediment collected from two beaches of similar characteristics but different pollution conditions, was studied over 24 h. No significant differences were observed between the two sediments. Secondly, embryogenesis success of Venerupis rhomboideus was recorded after incubation in seawater and elutriates obtained from affected areas. In this case, fuel-polluted seawater showed a marked inhibition of embryogenesis, while sediment elutriates showed moderate toxicity. Parallel bioassays with the diatom Skeletonema costatum were carried out using sediment elutriates and filtered seawater from the sampling sites. The response variable measured was the maximum quantum yield of photosynthesis (Φpo) using a Fast Repetition Rate Fluorometer (FRRF). In the first sampling, significant differences were found in the response of S. costatum cultured in the elutriates as compared to the control after 5 h exposure. The results corresponding to the second sampling showed statistically significant lower values of Φpo in the culture incubated in M2 water as compared with the control, indicating that the water-accommodated fraction of fuel at this site was the most toxic.
AVALIAÇÃO DO DESEMPENHO DO TRATAMENTO DE ESGOTOS SANITÁRIOS POR REATOR UASB SEGUIDO DE FILTRAÇÃO POR MEMBRANAS SUBMERSAS
Authors: Felizatto Mauro Roberto , De Souza Marco Antonio Almeida , Nery Felipe Coelho , Gontijo Norma 
Published: August 2017

<p> </p><p>A incorporação da tecnologia de separação por membranas em processos anaeróbios (tal qual o reator UASB) representa uma inovação importante no desenvolvimento da engenharia de tratamento de águas residuárias, principalmente quando se deseja realizar o reúso de água. Esta pesquisa consistiu na avaliação da microfiltração através de membranas submersas, provido de sistema de retrolavagem, durante o tratamento contínuo do efluente de reator UASB operando com esgotos sanitários. As membranas utilizadas foram do tipo fibras-ocas fabricadas com o polímero poli(éter-imida). Como conclusão, os experimentos de longo termo realizados revelaram que a remoção alcançada pela microfiltração do efluente do reator UASB foi de 87% para Demanda Bioquímica de Oxigênio (DBO), 84% para Demanda Química de Oxigênio (DQO), 99% para Sólidos em Suspensão Totais (SST) e 2,02 unidades logarítmicas para Coliformes Fecais (CF).</p><p><span style="font-family: Arial; font-size: small;"><br /></span></p>
Stochastic dynamics of intermittent pore‐scale particle motion in three‐dimensional porous media: Experiments and theory
Authors: Morales V. L. , Dentz M. , Willmann M. , Holzner M. 
Published: August 2017

AbstractWe study the evolution of velocity in time, which fundamentally controls the way dissolved substances are transported and spread in porous media. Experiments are conducted that use tracer particles to track the motion of substances in water, as it flows through transparent, 3‐D synthetic sandstones. Particle velocities along streamlines are found to be intermittent and strongly correlated, while their probability density functions are lognormal and nonstationary. We demonstrate that these particle velocity characteristics can be explained and modeled as a continuous time random walk that is both Markovian and mean reverting toward the stationary state. Our model accurately captures the fine‐scale velocity fluctuations observed in each tested sandstone, as well as their respective dispersion regime progression from initially ballistic, to superdiffusive, and finally Fickian. Model parameterization is based on the correlation length and mean and standard deviation of the velocity distribution, thus linking pore‐scale attributes with macroscale transport behavior for both short and long time scales.
The role of ocean fluxes and radiative forcings in determining tropical rainfall shifts in RCP8.5 simulations
Authors: McFarlane Ashly Ann , Frierson Dargan M. W. 
Published: August 2017

AbstractWe use Coupled Model Intercomparison Project global climate models forced with the Representative Concentration Pathway (RCP) 8.5 scenario to attribute tropical precipitation shifts under global warming scenarios and changes in cross‐equatorial atmosphere heat transport (c‐eq AHT) to changes in ocean and radiative fluxes. We find that the models tend to agree on the sign of c‐eq AHT and change in precipitation asymmetry induced by each forcing, but not the magnitude. The ice‐albedo feedback and aerosol emission reduction lead to the Northern Hemisphere warming, but this is countered by a reduction to the Atlantic Meridional Overturning Circulation northward heat transport and increased longwave leading to the multimodel mean change in precipitation asymmetry being approximately zero. None of the forcings considered, including aerosol cleanup, can account for more than 20% of the multimodel mean change in c‐eq AHT alone.
Observation of ionospherically reflected quasiperiodic emissions by the DEMETER spacecraft
Authors: Hanzelka Miroslav , Santolík Ondřej , Hajoš Mychajlo , Němec František , Parrot Michel 
Published: August 2017

AbstractQuasiperiodic (QP) electromagnetic emissions are whistler mode waves at typical frequencies of a few kHz characterized by a periodic time modulation of their intensity. The DEMETER spacecraft observed events where the QP emissions exhibit a sudden change in the wave vector and Poynting vector directions. The change happens in a short interval of latitudes. We explain this behavior by ionospheric reflection and present a ray‐tracing simulation which matches resulting wave vector directions. We also attempt to locate the source region of these emissions and conclude that they are most probably generated at the inner boundary of the plasmapause which also acts as a guide during the propagation of the QP emissions.
Reversible Attachment with Tailored Permeability: The Feather Vane and Bioinspired Designs
Authors: Sullivan Tarah N. , Chon Michael , Ramachandramoorthy Rajaprakash , Roenbeck Michael R. , Hung Tzu‐Tying , Espinosa Horacio D. , Meyers Marc A. 
Published: August 2017

AbstractIn bird flight, the majority of the wing surface consists of highly refined and hierarchically organized feathers. They are composed of barbs that stem from the feather shaft and barbules that branch from barbs, forming a rigid feather vane. Barbules provide adhesion within the vane through an interlocking hook‐and‐groove mechanism to allow for the effective capture of air. This functional adhesive can reattach if structures unfasten from one another, preventing catastrophic damage of the vane. Here, using pelican primary feathers as a model material, we investigate the in‐plane adhesion and stiffness of barbules. With guineafowl, pelican, and dove feathers, we determine the effect of barbules on the feather vane's ability to capture air. The vane is found to have directional permeability, and the effect of detaching barbules on the feather's competency is determined to be a function of barb dimensions. Interestingly, barbule spacing is found to vary within a narrow 8–16 µm range for birds weighing from 4–11 000 g (hummingbird to condor). Additionally, bioinspired barbules are fabricated through additive manufacturing to study the complexities of the vane. Barbules are underexplored structures imperative to the adeptness of the feather in flight, with the potential to provide bioinspired aerospace materials.
Comparison of Simulation‐based Resuscitation Performance Assessments With In‐training Evaluation Reports in Emergency Medicine Residents: A Canadian Multicenter Study
Authors: Hall Andrew Koch , Damon Dagnone J. , Moore Sean , Woolfrey Karen G. H. , Ross John A. , McNeil Gordon , Hagel Carly , Davison Colleen , Sebok‐Syer Stefanie S. 
Published: August 2017

AbstractObjectiveSimulation stands to serve an important role in modern competency‐based programs of assessment in postgraduate medical education. Our objective was to compare the performance of individual emergency medicine (EM) residents in a simulation‐based resuscitation objective structured clinical examination (OSCE) using the Queen's Simulation Assessment Tool (QSAT), with portfolio assessment of clinical encounters using a modified in‐training evaluation report (ITER) to understand in greater detail the inferences that may be drawn from a simulation‐based OSCE assessment.MethodsA prospective observational study was employed to explore the use of a multicenter simulation‐based OSCE for evaluation of resuscitation competence. EM residents from five Canadian academic sites participated in the OSCE. Video‐recorded performances were scored by blinded raters using the scenario‐specific QSATs with domain‐specific anchored scores (primary assessment, diagnostic actions, therapeutic actions, communication) and a global assessment score (GAS). Residents’ portfolios were evaluated using a modified ITER subdivided by CanMEDS roles (medical expert, communicator, collaborator, leader, health advocate, scholar, and professional) and a GAS. Correlational and regression analyses were performed comparing components of each of the assessment methods.ResultsPortfolio review and ITER scoring was performed for 79 residents participating in the simulation‐based OSCE. There was a significant positive correlation between total OSCE and ITER scores (r = 0.341). The strongest correlations were found between ITER medical expert score and each of the OSCE GAS (r = 0.420), communication (r = 0.443), and therapeutic action (r = 0.484) domains. ITER medical expert was a significant predictor of OSCE total (p = 0.002). OSCE therapeutic action was a significant predictor of ITER total (p = 0.02)ConclusionsSimulation‐based resuscitation OSCEs and portfolio assessment captured by ITERs appear to measure differing aspects of competence, with weak to moderate correlation between those measures of conceptually similar constructs. In a program of competency‐based assessment of EM residents, a simulation‐based OSCE using the QSAT shows promise as a tool for assessing medical expert and communicator roles.
Visible light crosslinkable human hair keratin hydrogels
Authors: Yue Kan , Liu Yanhui , Byambaa Batzaya , Singh Vaishali , Liu Wanjun , Li Xiuyu , Sun Yunxia , Zhang Yu Shrike , Tamayol Ali , Zhang Peihua , Ng Kee Woei , Annabi Nasim , Khademhosseini Ali 
Published: August 2017

AbstractKeratins extracted from human hair have emerged as a promising biomaterial for various biomedical applications, partly due to their wide availability, low cost, minimal immune response, and the potential to engineer autologous tissue constructs. However, the fabrication of keratin‐based scaffolds typically relies on limited crosslinking mechanisms, such as via physical interactions or disulfide bond formation, which are time‐consuming and result in relatively poor mechanical strength and stability. Here, we report the preparation of photocrosslinkable keratin‐polyethylene glycol (PEG) hydrogels via the thiol‐norbornene “click” reaction, which can be formed within one minute upon irradiation of visible light. The resulting keratin‐PEG hydrogels showed highly tunable mechanical properties of up to 45 kPa in compressive modulus, and long‐term stability in buffer solutions and cell culture media. These keratin‐based hydrogels were tested as cell culture substrates in both two‐dimensional surface seeding and three‐dimensional cell encapsulation, demonstrating excellent cytocompatibility to support the attachment, spreading, and proliferation of fibroblast cells. Moreover, the photocrosslinking mechanism makes keratin‐based hydrogel suitable for various microfabrication techniques, such as micropatterning and wet spinning, to fabricate cell‐laden tissue constructs with different architectures. We believe that the unique features of this photocrosslinkable human hair keratin hydrogel promise new opportunities for their future biomedical applications.
Cytoskeleton and nucleoskeleton involvement in processes of cytomixis in plants
Authors: Kravets Elena Adolphovna , Yemets Alla Ivanovna , Blume Yaroslav Borisovich 
Published: August 2017

AbstractCytomixis is a form of cell‐to‐cell nuclear migration that involves the interaction of dynamic cytoskeletal components with the nucleus through signalling systems and linker complexes. In cytomixis two known mechanisms can be involved: actomyosin and/or microtubules and their associated motors. Perinuclear actin anchors and determines the direction of nuclear movement. In microsporogenesis cytomixis is probably initiated by a cascade of signals that trigger prophase reorganization of nucleus and cytoskeleton, and is a result of cytoskeletal protein activation, as well as a weakening of mechanisms responsible for anchoring the nucleus. The interactions between nuclei and the cytoskeleton are mediated by linker complexes that play a major role in nuclear positioning and shape, chromatin–nuclear envelope interactions, nucleoskeleton organization, gene expression and genome organization. Other contributing factors include changes in the protein composition and post‐translational modifications that alter protein conformation. Cytomixis appears also to have relevance to higher order structuring, influencing tissue and organ architecture, causing collective forms of cell interactions and information exchange within a single continuum. In this review we summarize our current understanding of the cytoskeleton dynamic function in cytomictic nuclear migration.
Cover Picture: A Novel Dual Channel Fluorescent Probe for Ca2+ and Zn2+ Based on a Coumarin Schiff Base (Chin. J. Chem. 8/2017)
Authors: Pan Shengnan , Tang Haoyang , Song Zhanke , Li Jin , Guo Yuan 
Published: August 2017

The cover picture shows a novel dual channel fluorescent probe for Ca2+ and Zn2+ based on a coumarin Schiff base. The probe displays a solvent dependent dual sensing, viz., recognition of Ca2+ in DMF‐H2O (9∶1, V/V) solution based on C = N isomerization, photoinduced electron transfer (PET) inhibition and chelation‐enhanced fluorescence (CHEF) mechanism as well as detection of Zn2+ in H2O‐CH3OH (9∶1, V/V) solution by excited‐state intramolecular proton transfer (ESIPT) and CHEF processes. More details are discussed in the article by Guo et al. on page 1263–1269.
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Biophysical Screening of a Focused Library for the Discovery of CYP121 Inhibitors as Novel Antimycobacterials
Authors: Brengel Christian , Thomann Andreas , Schifrin Alexander , Allegretta Giuseppe , Kamal Ahmed A. M. , Haupenthal Jörg , Schnorr Isabell , Cho Sang Hyun , Franzblau Scott G. , Empting Martin , Eberhard Jens , Hartmann Rolf W. 
Published: August 2017

AbstractThe development of novel antimycobacterial agents against Mycobacterium tuberculosis (Mtb) is urgently required due to the appearance of multidrug resistance (MDR) combined with complicated long‐term treatment. CYP121 was shown to be a promising novel target for inhibition of mycobacterial growth. In this study, we describe the rational discovery of new CYP121 inhibitors by a systematic screening based on biophysical and microbiological methods. The best hits originating from only one structural class gave initial information about molecular motifs required for binding and activity. The initial screening procedure was followed by mode‐of‐action studies and further biological characterizations. The results demonstrate superior antimycobacterial efficacy and a decreased toxicity profile of our frontrunner compound relative to the reference compound econazole. Due to its low molecular weight, promising biological profile, and physicochemical properties, this compound is an excellent starting point for further rational optimization.
RGD Peptide‐Based Target Drug Delivery of Doxorubicin Nanomedicine
Authors: Sun Yuan , Kang Chen , Liu Fei , Zhou You , Luo Lei , Qiao Hongzhi 
Published: August 2017

ABSTRACT

Preclinical Research

Doxorubicin (DOX) is commonly used for the treatment of breast cancer and lymphoma. However, its clinical use has been severely limited due to cardiotoxicity, requiring the development of safer and more efficient pharmaceutical formulations of DOX. Advances in nanotechnology have provided new ways to administer chemotherapeutic drugs like DOX are conveyed into the body and to tumor sites. These Nanotechnology approaches have aided in the selective accumulation of DOX into tumor sites via the enhanced permeability and retention. However, the absence of active targeting ligands still hinders the effective delivery of DOX. Among all active targeting ligands developed to date, RGD peptide (Arginylglycylaspartic acid) occupies a unique position owing to its inherent safety, biocompatibility, and targeting ability. Accordingly, modification of DOX with RGD ligand is anticipated to improve transport of DOX into tumor cells. In this review, we discuss using RGD peptide for improving the therapeutic efficacy of DOX nanomedicine. Drug Dev Res 78 : 283–291, 2017. © 2017 Wiley Periodicals, Inc.
Development of a quantitative method for the analysis of cocaine analogue impregnated into textiles by Raman spectroscopy
Authors: Xiao Linda , Alder Rhiannon , Mehta Megha , Krayem Nadine , Cavasinni Bianca , Laracy Sean , Cameron Shane , Fu Shanlin 
Published: August 2017

AbstractCocaine trafficking in the form of textile impregnation is routinely encountered as a concealment method. Raman spectroscopy has been a popular and successful testing method used for in situ screening of cocaine in textiles and other matrices. Quantitative analysis of cocaine in these matrices using Raman spectroscopy has not been reported to date. This study aimed to develop a simple Raman method for quantifying cocaine using atropine as the model analogue in various types of textiles. Textiles were impregnated with solutions of atropine in methanol. The impregnated atropine was extracted using less hazardous acidified water with the addition of potassium thiocyanate (KSCN) as an internal standard for Raman analysis. Despite the presence of background matrix signals arising from the textiles, the cocaine analogue could easily be identified by its characteristic Raman bands. The successful use of KSCN normalised the analyte signal response due to different textile matrix background interferences and thus removed the need for a matrix‐matched calibration. The method was linear over a concentration range of 6.25–37.5 mg/cm2 with a coefficient of determination (R2) at 0.975 and acceptable precision and accuracy. A simple and accurate Raman spectroscopy method for the analysis and quantification of a cocaine analogue impregnated in textiles has been developed and validated for the first time. This proof‐of‐concept study has demonstrated that atropine can act as an ideal model compound to study the problem of cocaine impregnation in textile. The method has the potential to be further developed and implemented in real world forensic cases.