bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prostate Specific Antigen‐Growth Curve Model to Predict High‐Risk Prostate Cancer
Authors: Shoaibi Azza , Rao Gowtham A. , Cai Bo , Rawl John , Haddock Kathlyn Sue , Hébert James R. 
Published: October 2016

PURPOSETo investigate if a prostate specific antigen (PSA)‐derived growth curve can predict the occurrence of high‐risk prostate cancer (PrCA).METHODSData from 38,340 men randomized to the PrCA screening arm in the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO) were used to develop a PSA growth curve model to estimate PSA rate of change. The model was then used to predict high‐risk PrCA in clinical data available from 680,390 veterans seeking routine care. The PSA growth curve was modeled using non‐linear mixed regression and the PSA rate was estimated by taking the 1st derivative of the growth curve equation at 1 year prior to diagnosis/exit.RESULTSIn the PLCO, PrCA incidence was 8.1%; ≈19% of whom had high‐risk PrCA. Overall, a PSA rate threshold of 0.37 ng/ml/year had the best combination of sensitivity (97.2%) and specificity (97.3%) for detecting high‐risk PrCA. In the VA data; 7,347 men were diagnosed with PrCA; of these 4,315 (58.7%) were diagnosed with high‐risk PrCA. The PLCO optimal threshold of 0.37 ng/ml/year produced sensitivity = 95.5% and specificity = 85.2%. An optimal threshold of 0.99 ng/ml/year in AA produced sensitivity = 89.1% and specificity = 80.0%. PSA rate was a better predictor than the single last PSA value.CONCLUSIONSPSA growth curves predicted high‐risk PrCA in the PLCO data. Fitting the same algorithm in the VA data produced lower specificity. Although encouraging, this finding underlines the need for further research to prospectively test the algorithm, especially for African‐American men, the population group at highest risk of aggressive PrCA. Prostate 77:173–184, 2017. © 2016 Wiley Periodicals, Inc.
Anisotropic Elliott–Yafet theory and application to KC8 potassium intercalated graphite
Authors: Márkus Bence G. , Szolnoki Lénárd , Iván Dávid , Dóra Balázs , Szirmai Péter , Náfrádi Bálint , Forró László , Simon Ferenc 
Published: October 2016

AbstractWe report electron spin resonance (ESR) measurements on stage‐I potassium intercalated graphite (KC). Angular dependent measurements show that the spin–lattice relaxation time is longer when the magnetic field is perpendicular to the graphene layer as compared to when the magnetic field is in the plane. This anisotropy is analyzed in the framework of the Elliott–Yafet theory of spin‐relaxation in metals. The analysis considers an anisotropic spin–orbit Hamiltonian and the first order perturbative treatment of Elliott is reproduced for this model Hamiltonian. The result provides an experimental input for the first‐principles theories of spin–orbit interaction in layered carbon and thus to a better understanding of spin‐relaxation phenomena in graphene and in other layered materials as well.
Rapid detection of alteration of serum IgG in patients with schizophrenia after risperidone treatment by matrix‐assisted laser desorption ionization/time‐of‐flight mass spectrometry
Authors: Lo Li‐Hua , Shiea Jentaie , Huang Tiao‐Lai 
Published: October 2016

RationaleThe aim of the study was to use a technique that combines acid hydrolysis and matrix‐assisted laser desorption ionization/time‐of‐flight mass spectrometry (MALDI‐TOF MS) in order to detect the serum biomarkers of patients diagnosed with schizophrenia both before and after four‐week antipsychotic treatment with risperidone.MethodsDuring this study's two‐year period, inpatients were diagnosed with schizophrenia using the Structured Clinical Interview for DSM‐IV Axis I Disorders. Severity was then evaluated using the Positive and Negative Syndrome Scale both at baseline and at endpoint following four‐week treatment with risperidone. The patients' serum biomarkers were quickly measured using acid hydrolysis and MALDI‐TOF MS. The resulting peptides were then analyzed using MALDI‐TOF MS. We constructed a receiver operating characteristic (ROC) curve for the evaluated biomarkers.ResultsWe recruited 20 pairs of participants for this study. The experimental group was treated with serum protein with HCl for 10 minutes to effectively hydrolyze abundant proteins. The target peptide, the immunoglobulin gamma chain (IgG), was then rapidly detected using this manner. A significant difference was found in the IgG levels of patients with schizophrenia before and after antipsychotic treatment. We constructed a ROC curve based on the IgG, and the area under said curve was 0.969. In comparison to conventional detection protocols, this method takes only minutes to complete and is also less costly.ConclusionsThis study found that applying acid hydrolysis with MALDI‐TOF MS technology could rapidly differentiate serum IgG levels in patients with schizophrenia before and after being treated with risperidone. This IgG difference may enhance the understanding of mechanism of antipsychotic treatment of schizophrenia. Copyright © 2016 John Wiley & Sons, Ltd.
A CRT‐based verifiable secret sharing scheme secure against unbounded adversaries
Authors: Ersoy Oğuzhan , Pedersen Thomas Brochmann , Kaya Kamer , Selçuk Ali Aydın , Anarim Emin 
Published: October 2016

AbstractFor commitments on secrets, statistical hiding is a must when we are dealing with a long‐term secret or when the secret domain is small enough for a brute‐force attack by a powerful adversary. Unfortunately, all the Chinese Remainder Theorem‐based verifiable secret sharing schemes in the literature are either insecure or suffer from the vulnerability of computationally hiding commitments. To the best of our knowledge, there exist five such studies where two of them were already proven to be insecure. In this work, we first show that two of the remaining schemes are also insecure, that is, the schemes reveal information on the secret even when the adversary is passive. In addition, the remaining one is only secure against a computationally bounded adversary which can be a problem for secret sharing schemes requiring long‐term secret obscurity or using small secret domain. We propose a modification for the latter scheme and prove that the modified scheme is a secure verifiable secret sharing scheme against an unbounded adversary. Lastly, as an application, we show how to use the new scheme for joint random secret sharing and analyze the practicality and efficiency of the proposed schemes. Copyright © 2016 John Wiley & Sons, Ltd.
A novel approach for privacy homomorphism using attribute‐based encryption
Authors: Doshi Nishant , Jinwala Devesh C. 
Published: October 2016

AbstractIn CRYPTO'13, Gentry et al. proposed the first homomorphic encryption (HE) scheme for the attribute‐based encryption (ABE). However, Gentry's scheme requires the same index for encryption of each ciphertext and supports only the key‐policy ABE. Indeed, in SECRYPT'13, Clear et al. left an open problem in the Gentry et al. scheme viz. a scheme that requires different sets of index in HE using ABE and supports the ciphertext‐policy ABE (CP‐ABE), where the sender is assumed to be intelligent. In addition, in INDOCRYPT'12, Vaikuntanathan discussed an open problem viz. to work out the HE using cryptographic techniques other than lattice‐based cryptography. With an aim to propose the CP‐ABE scheme using HE, in this research attempt, we propose an approach that integrates the benefits of HE in CP‐ABE and yet uses pairing‐based cryptography. In our approach viz. attribute‐based HE (AB‐HE), a user is able to successfully decrypt the ciphertext only if the attributes in the policy match those in the secret key. However, in addition, our approach also allows multiple invocations of multiplication operation on the ciphertext as in a typical partially HE, coupling the advantages of the partial HE in the CP‐ABE. Further, we also propose an extension of the proposed scheme that serves as a pseudo‐fully HE, but requires the help of a key authority. The security of the proposed scheme is based on the decisional bilinear Diffie–Hellman problem. To the best of our knowledge, ours is a unique attempt in integrating HE into the attribute‐based cryptography with different indexes/policies. In addition, our AB‐HE scheme is pairing‐based, and by adding more ciphertexts, it does not blow the final ciphertext size because we use the constant length ciphertext approach for the encryption. Copyright © 2016 John Wiley & Sons, Ltd.
A new taxon of cistecephalid dicynodont from the upper Permian Kundaram Formation of India
Authors: Kammerer Christian F. , Bandyopadhyay Saswati , Ray Sanghamitra 
Published: October 2016

AbstractA new cistecephalid dicynodont,Sauroscaptor tharavatigen. et sp. nov., is described from the upper Permian Kundaram Formation of India. This taxon is represented by specimens formerly referred to the African dicynodont generaCistecephalusandEmydops.Sauroscaptorcan be distinguished from other cistecephalids by the extremely posterior position of the pineal foramen (overhanging the edge of the occiput), bipartite nuchal crest, and relatively narrow skull roof. The recognition ofSauroscaptoras a distinct cistecephalid taxon adds to the increasing evidence for high levels of basinal endemism in this family. However, dicynodont biogeographical patterns are complex, and there is no simple relationship between inferred dispersal ability based on body size and levels of endemicity within clades.
Bürogebäude mit städtebaulicher Funktion
Authors: Seidel Marc 
Published: October 2016

AbstractZentral gelegen im Bonner Bundesviertel befindet sich seit dem Jahr 2013 die moderne Unternehmenszentrale der Beratungsgesellschaft DHPG. Das fünfgeschossige Bürogebäude zeichnet sich in seiner Außenwirkung durch die elegante Kombination aus Glas und Beton mit markanter Rippenstruktur und einem Stahlverbundtragwerk aus. Das Bauunternehmen Goldbeck war von der Planungsberatung an über die gesamte Ausführung bis zur schlüsselfertigen Übergabe für das Bauvorhaben verantwortlich. Im Rahmen eines vorgeschalteten Architektenwettbewerbs wurde das Büro Prof. Schmitz Architekten mit der architektonischen Gestaltung beauftragt. Errichtet wurde das Gebäude innerhalb von nur 16 Monaten. Der Rohbau besteht komplett aus Systembauteilen mit einem hohen Vorfertigungsgrad, die gestapelte Fassade entwickelten Goldbeck und die Architekten aus Betonfertigteilen mit individueller Rezeptur. Beim Innenausbau standen der Komfortgedanke und ein kommunikatives Arbeitsumfeld unter Nutzung einer einheitlichen Designsprache im Mittelpunkt. Der Beitrag beleuchtet am Beispiel DHPG die Vielseitigkeit und die Vorteile der elementierten Systembauweise.Office building with an impact on urban architecture – DHPG Head Office in Bonn. The modern head office of the advisory firm DHPG has been centrally located in Bonn's Federal Quarter (Bundesviertel) since 2013. Due to its elegant combination of glass and concrete featuring prominent ribbing and a composite steel structure, the five‐storey office building stands out from its surroundings. Goldbeck consulted on planning and design, and oversaw the entire construction project from the beginning to turnkey handover. Prof. Schmitz Architekten won an architectural competition prior to the project and was commissioned to design the building's architecture. Construction took just 16 months. The shell is made entirely of system components, many of which were pre‐fabricated. Goldbeck and the architects developed the graduated facade from customised precast concrete elements. Interior design and construction centred on comfort and a communicative working environment with a uniform design language. The article highlights the diversity and advantages of system construction based on the example of DHPG.
Ersatzneubau der Talbrücke Heidingsfeld
Authors: Langer Stephan 
Published: October 2016

Abstract50 Jahre nach ihrer Erbauung weicht die 665 m lange Talbrücke Heidingsfeld einem Ersatzneubau. Dabei kommt für den Stahlverbundüberbau aus dem Jahr 1964 erneut ein Stahlverbundquerschnitt zum Zuge, der je Fahrtrichtung durch einen modernen einzelligen Stahlhohlkasten mit außenliegenden Kragarmen und aufbetonierter Fahrbahnplatte gebildet wird. Aufgrund der topographischen Verhältnisse und der Bedingungen zur Aufrechterhaltung eines 4+0‐Verkehrs erfolgt die Montage durch Längseinschub der Stahlkonstruktion mit Stützweiten bis zu 120 m.Replacement of the viaduct Heidingsfeld. 50 years after its construction the 665 m long viaduct Heidingsfeld will be totally replaced. Hereby the steel composite superstructure from 1964 is constructed again as a steel composite section, which is formed in every roadway by a modern unicellular steel box with external cantilevers and concreted slab. Due to the topographical conditions and the conditions for maintaining a 4+0 traffic the steel construction will be installed by longitudinal launching with spans up to 120 m.
Rio 2016 – Ein Rückblick
Authors: Stockhusen Knut 
Published: October 2016

AbstractWenn man schon nicht als Sportler bei den Olympischen Spielen teilnehmen kann, dann bietet der Beruf des Ingenieurs wider Erwarten eine Alternative. Es gibt garantiert keine Medaillen zu gewinnen, aber auch hier gilt “Dabeisein ist alles”. Dass “unser” Maracanã‐Stadion eine Hauptrolle bei der Olympiade spielen würde, war zu erwarten. Dass wir Teil des Teams zur Planung der Eröffnungs‐ und Schlusszeremonie werden würden, und somit ein ganz ungewöhnliches Betätigungsfeld für Ingenieure erschließen würden, war nicht vorherzusehen. Auch die restlichen Planungsaufgaben für die größtenteils temporären Tennis‐ und Schwimmanlagen und die Live Site eröffneten neue Perspektiven und Herausforderungen. Alles in allem waren es sehr spannende Jahre mit einem tollen Finale.Rio 2016. If you can't make it to the Olympics as an athlete, then maybe you should try engineering. There's no medals to be won, but the most important thing is to take part. That “our” Maracanã Stadium would play a major role at the Olympics goes without saying, but the fact that we would end up being part of the team to plan the opening and closing ceremonies went well beyond our expectations, opening up a very different field of engineering. Even the planning for the (in large parts) temporary tennis and swimming facilities revealed a host of new perspectives and challenges. Altogether, it was a very exciting time with beautiful games.
Surgical Strategy and Outcome in Patients Undergoing Pancreaticoduodenectomy After Gastric Resection: A Three‐Center Experience with 39 Patients
Authors: Lee Dooin , Lee Jae Hoon , Choi Dongho , Kang Chang Moo , Chong Jae Uk , Kim Song‐Chul , Lee Kyeong Geun 
Published: October 2016

AbstractBackgroundStomach cancer is the second most commonly diagnosed cancer in Korea. Although the long‐term survival outcome has improved, secondary primary tumors from periampullary regions are increasing inevitably and pancreaticoduodenectomy (PD) following gastrectomy is challenging. This study evaluates the surgical outcomes of PD following gastrectomy and suggests the optimum method for reconstruction.MethodsPatients who underwent curative PD with a history of gastric resection between 2005 and 2015 were assessed retrospectively. PD was performed according to the standard fashion, with the aim of creating a new pancreaticobiliary limb with sufficient length (40–50 cm). Different reconstructive methods were employed during PD according to the previous gastrectomy type.ResultsA total of 3064 patients underwent PD, 39 of whom had previous gastrectomies including 12 with Billroth I gastrectomy, 20 with Billroth II gastrectomy, and seven patients with total gastrectomy (TG). In patients with Billroth I gastrectomy, all of the previous gastroduodenostomy site was resected for specimen retrieval. All previous esophagojejunostomy site was preserved in seven patients who had TG. In the Billroth II patients, the gastrojejunostomy site was preserved in 17 patients. Re‐operation after PD was required in two patients, and 14 patients (36 %) developed pancreatic fistula and five (13 %) of grade B or higher.ConclusionsOur study has been the largest report so far of PD following gastric resection, and we were able to confirm the safety and the feasibility of PD procedure. We therefore suggest standardizing the reconstruction method for PD following gastrectomy based on the type of previous gastrectomy.
Stanniocalcin 1 Enhances Carbon Flux from Glucose to Lipids in White Retroperitoneal Adipose Tissue in the Fed Rat
Authors: Cozer Aline G. , Trapp Márcia , Vieira Marques Claudia , Martins Tiago L. , Model Jorge Felipe A. , Schein Vanessa , Kucharski Luiz Carlos , Da Silva Roselis S. M. 
Published: October 2016

AbstractThe present work assesses in vitro the role of human Stanniocalcin 1 (hSTC‐1) in glucose metabolism in white retroperitoneal adipose tissue (WRAT) from fed rat. In the fed state, hSTC1 increases the incorporation of 14C from glucose into lipids in the rat WRAT. The increase in lipogenesis capacity supports the hypothesis that the activity of the glycerol‐3‐phosphate‐generating pathway (glycolysis) from glucose is regulated by hSTC‐1. The effect of hSTC‐1 on de novo fatty acid synthesis and on glucose oxidation in WRAT is supported by an 85 % increase in 14CO2 production from 14C‐glucose. The incubation of WRAT in the presence of hSTC‐1 maintained the ADP/ATP ratio close to the control group. The presence of hSTC‐1 in the incubation medium did not inhibit the lipolytic effect of epinephrine. In conclusion, hSTC‐1 is one of the hormonal factors that control glucose metabolism in WRAT in the fed state.
Histological and adhesiogenic characterization of the Zenapro Hybrid Hernia Repair Device
Authors: Hodde Jason P. , Suckow Mark D. , Johnson Chad , Rodenberg Eric , Ritchie Rae D. 
Published: October 2016

Abstract

Background
A major clinical problem relating to hernia repair is the formation of intra-abdominal, post-surgical adhesions when mesh products are used to reinforce the abdominal wall. To achieve better outcomes, more technologically-advanced products designed to achieve permanence of repair while eliminating serious complications such as adhesion formation are needed. This study was designed to assess the histological remodeling and adhesiogenic properties of the Zenapro™ Hybrid Hernia Repair Device as compared to uncoated and coated polypropylene.

Materials and Methods
Zenapro™, Prolene® and Ventralight® ST Mesh were implanted to repair full-thickness abdominal wall defects in rabbits and rats and were allowed to survive for various lengths of time. Animals were euthanized, the implants were identified, and the extent and tenacity of adhesions were evaluated. Tissue samples were collected and evaluated for inflammation, integration of the mesh with the abdominal wall, and collagen deposition.

Results
A significant difference was found in the extent of adhesions in the Prolene group as compared to the Zenapro group (p = 0.021) and the Ventralight ST group (p = 0.04) in the rat study. The tenacity of the adhesions in the Prolene mesh group trended higher than in the other groups but failed to reach statistical significance. Histological evaluation demonstrated that collagen accumulation was greatest for the Zenapro implants as compared to either the Ventralight ST or Prolene samples. At the conclusion of 6-months in the rabbit model, the Zenapro sites showed signs of a thicker repair composed of more organized mature collagen than was seen in the Ventralight ST samples. Neither device was found to elicit any sort of detrimental inflammatory tissue reaction.

Conclusion
A combination hernia device composed of a complete extracellular matrix with a synthetic mesh can result in enhanced tissue ingrowth and neovascularization while maintaining high tensile strength and mitigating adhesiogenic effects.

Highlights
Lamivudine switch therapy in chronic hepatitis B patients achieving undetectable hepatitis B virus DNA after 3 years of entecavir therapy: A prospective, open‐label, multicenter study
Authors: Yeh Ming‐Lun , Huang Ching‐I. , Hsieh Ming‐Yen , Huang Chung‐Feng , Hsieh Meng‐Hsuan , Huang Jee‐Fu , Dai Chia‐Yen , Lin Zu‐Yau , Chen Shinn‐Chern , Yu Ming‐Lung , Chuang Wan‐Long 
Published: October 2016

AbstractThe subsequent maintenance therapy in chronic hepatitis B (CHB) patients after long‐term viral replication suppression is still uncertain. We aim to evaluate the efficacy of lamivudine (LAM) maintenance therapy in CHB patients achieving undetectable hepatitis B virus (HBV) DNA after 3 years of entecavir (ETV) therapy. Consecutive CHB patients who received at least 3 years of ETV and achieved HBV DNA negativity were allocated either LAM switch therapy or stopped ETV therapy in a prospective, open‐label study. Another group of sex‐ and age‐matched patients with continuous ETV therapy for at least 4 years served as historical control group. The primary outcome measurement of the study was relapse of HBV DNA (defined as serum HBV DNA level ≥ 2000 IU/mL). A total of 74 patients, including 42 of LAM switch and 32 of the nonswitch group, were enrolled. There were no significant differences in demographics, except a higher proportion of patients with positive hepatitis B envelope antigen in the nonswitch group at the initiation of ETV therapy. The LAM switch group had significantly lower 1‐year relapse rate of HBV within 1 year compared to the nonswitch group (14.3% vs. 75%, p < 0.001). However, none of the 48 historical control patients developed relapse of HBV, which was significantly lower than the rate in LAM switch group (p < 0.001). LAM switch was the only factor associated with HBV DNA relapse. In conclusion, continuous long‐term potent nucleot(s)ide analogue therapy is mandatory for prevention of viral relapse in CHB patients.
DNA N6-methyladenine demethylase ALKBH1 enhances osteogenic differentiation of human MSCs
Authors: Zhou Chenchen , Liu Yuting , Li Xiaobing , Zou Jing , Zou Shujuan 
Published: October 2016

AbstractALKBH1 was recently discovered as a demethylase for DNA N6-methyladenine (N6-mA), a new epigenetic modification, and interacts with the core transcriptional pluripotency network of embryonic stem cells. However, the role of ALKBH1 and DNA N6-mA in regulating osteogenic differentiation is largely unknown. In this study, we demonstrated that the expression of ALKBH1 in human mesenchymal stem cells (MSCs) was upregulated during osteogenic induction. Knockdown of ALKBH1 increased the genomic DNA N6-mA levels and significantly reduced the expression of osteogenic-related genes, alkaline phosphatase activity, and mineralization. ALKBH1-depleted MSCs also exhibited a restricted capacity for bone formation in vivo. By contrast, the ectopic overexpression of ALKBH1 enhanced osteoblastic differentiation. Mechanically, we found that the depletion of ALKBH1 resulted in the accumulation of N6-mA on the promoter region of ATF4, which subsequently silenced ATF4 transcription. In addition, restoring the expression of ATP by adenovirus-mediated transduction successfully rescued osteogenic differentiation. Taken together, our results demonstrate that ALKBH1 is indispensable for the osteogenic differentiation of MSCs and indicate that DNA N6-mA modifications area new mechanism for the epigenetic regulation of stem cell differentiation.