bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of genetic and clinical characteristics of a Chinese Kallmann syndrome cohort with ANOS1 mutations
Authors: Nie Min , Xu Hongli , Chen Rongrong , Mao Jiangfeng , Wang Xi , Xiong Shuyu , Zheng Junjie , Yu Bingqing , Cui Mingxuan , Ma Wanlu , Huang Qibin , Zhang Hongbing , Wu Xueyan 
Published: August 2017

ObjectiveTo analyzeANOS1gene mutations in a large Chinese Kallmann syndrome (KS) cohort and to characterize the clinical presentation of the disease in patients withANOS1mutations.Patients and methodsChinese patients with KS, including 187 sporadic and 23 pedigree cases were recruited. Patients’ANOS1gene sequences were analyzed by direct sequencing of PCR-amplified products.In silicoanalysis was used to assess functional relevance of newly identified missense mutations. Patients’ clinical characteristics were analyzed retrospectively.Result(s)Fifteen nonsynonymous rareANOS1variants were found in 13 out of 187 sporadic and 8 out of 23 familial IHH probands. Seven novel (C86F, C90Y, C151W, Y379X, c.1062 + 1G > A, Y579L fs 591X, R597X) and eight recurrentANOS1mutations (S38X, R257X, R262X, R423X, R424X, V560I, c.1843-1G > A, p.R631X) were identified. All the novel mutations were predicted to be pathogenic. The prevalence of cryptorchidism was high (38.1%) and occurred in patients with different kind ofANOS1mutations, while the patients with the same mutation did not present with cryptorchidism uniformly.Conclusion(s)The prevalence ofANOS1gene mutations is low in sporadic KS patients, but is much higher in familial KS patients. In the present study, we identify seven novelANOS1mutations, including two mutations in the CR domain, which are probably pathogenic. These mutations expand theANOS1mutation spectrum and provide a foundation for prenatal diagnosis and genetic counseling.
Effects of mitotane on the hypothalamic–pituitary–adrenal axis in patients with adrenocortical carcinoma
Authors: Reimondo Giuseppe , Puglisi Soraya , Zaggia Barbara , Basile Vittoria , Saba Laura , Perotti Paola , De Francia Silvia , Volante Marco , Zatelli Maria Chiara , Cannavò Salvatore , Terzolo Massimo 
Published: August 2017

Objective
Mitotane, a drug used to treat adrenocortical cancer (ACC), inhibits multiple enzymatic steps of adrenocortical steroid biosynthesis, potentially causing adrenal insufficiency. Recent studies in vitro have also documented a direct inhibitory effect of mitotane at the pituitary level. The present study was aimed to assess the hypothalamic–pituitary–adrenal axis in patients with ACC receiving mitotane.

Design and methods
We prospectively enrolled 16 patients on adjuvant treatment with mitotane after radical surgical resection of ACC, who underwent standard hormone evaluation and h-CRH stimulation. A group of 10 patients with primary adrenal insufficiency (PAI) served as controls for the CRH test.

Results
We demonstrated a close correlation between cortisol-binding globulin (CBG) and plasma mitotane levels, and a non-significant trend between mitotane dose and either serum or salivary cortisol in ACC patients. We did not find any correlation between the dose of cortisone acetate and either ACTH or cortisol levels. ACTH levels were significantly higher in patients with PAI than that in patients with ACC, both in baseline conditions (88.99 (11.04–275.00) vs 24.53 (6.16–121.88) pmol/L, P = 0.031) and following CRH (158.40 (34.32–275.00) vs 67.43 (8.8–179.52) pmol/L P = 0.016).

Conclusions
The observation of lower ACTH levels in patients with ACC than that in patients with PAI, both in basal conditions and after CRH stimulation, suggests that mitotane may play an inhibitory effect on ACTH secretion at the pituitary levels. In conclusion, the present study shows that mitotane affects the HPA axis at multiple levels and no single biomarker may be used for the assessment of adrenal insufficiency.
Manifestaciones artísticas y culturales afrocolombianas. Una aproximación al caso de Girardota (Antioquia)
Authors: Larraín González América , Madrid Garcés Pedro José 
Published: August 2017

Tomando como punto de partida una etnografía realizada entre 2015 y 2016, este artículo ofrece una descripción de los elementos que componen el escenario de las manifestaciones artísticas y culturales de una comunidad afrodescendiente en el municipio de Girardota, Antioquia. Por este camino, llegamos a la conclusión de que hay un lazo indisociable entre la participación de la comunidad en escenarios políticos y de organización comunitaria, y el carácter étnico que se atribuye a sus manifestaciones artísticas y culturales. Aquí privilegiamos un enfoque que entiende dichas manifestaciones como un vehículo para acceder a reflexiones históricas, sociales y políticas, exponiendo cómo, tras la Constitución de 1991 y con la implementación del discurso del multiculturalismo en Colombia, la población de ascendencia africana reformula su identidad étnica para establecer un vínculo diferencial con su historia esclava y servil.
El papel del Estado colombiano en la conformación del sector siderúrgico de Boyacá. 1938-1980
Authors: Barreto Bernal Patricia Carolina , Jurado Jurado Juan Carlos 
Published: August 2017

En este artículo se expone el papel del Estado colombiano en la conformación del sector siderúrgico del Departamento de Boyacá, entre 1938 y 1980. El intervencionismo del Estado colombiano ha sido un elemento fundamental para la sustitución de importaciones explicable por las condiciones endógenas y exógenas de la economía nacional durante la Segunda Guerra Mundial (1939-1945). Se parte de la hipótesis de que el Estado es la forma política que ha adoptado el sistema económico capitalista y por tanto el intervencionismo estatal en la economía es característica del proceso de modernización que se experimentó en Colombia entre finales del siglo XIX y principios del siglo XX. Se abordan las políticas y leyes estatales del sector siderúrgico, las instituciones estatales y gremiales que lo desarrollaron, el declive del intervencionismo y el surgimiento de siderúrgicas privadas. Se consultaron fuentes secundarias, prensa nacional, la revista oficial del gremio durante las décadas de 1960 y 1970 y CONPES. Por último, es de resaltar algunos puntos clave que se encuentran fuera del alcance del presente estudio como lo son la interrelación del sector siderúrgico con otros sectores y los flujos de conocimiento y tecnologías nacionales e internacionales que se requerían para el montaje de grandes empresas; ideas vitales para generar nuevos procesos investigativos.
A robust approach based on time variable trigger levels for pump control
Authors: Alvisi Stefano , Franchini Marco 
Published: August 2017

AbstractAn approach for the control of a pumping plant feeding a tank at the inlet of a water distribution system is presented. The approach is aimed at minimizing the energy costs by maximizing pumping during off-peak electricity tariff periods. It is based on trigger levels which are variable during the day according to a prefixed pattern in order to ensure that the water level in the elevated tank is at its minimum and maximum values at the end of the peak and off-peak tariff periods, respectively. The pattern of the trigger levels is defined by solving a multi-objective problem aimed at minimizing the energy costs and the number of pump switches. The approach was applied to a couple of real cases with a single tank. The approach was compared with other methodologies typically used for pump control, i.e. fixed trigger levels (FTLs) and pump scheduling (PS). The results show for the two particular cases that the proposed approach achieves energy costs that are lower than those obtainable by using FTLs, and comparable with those obtainable by using PS. This is based on achieving a similar number of pump switches.
Layanan bimbingan kelompok dalam meningkatkan komunikasi interpersonal siswa
Authors: Fijriani Fijriani , Amaliawati Rediska 
Published: August 2017

Tujuan penelitian ini adalah untuk mengetahui efektifitas pelayanan konseling kelompok dalam meningkatkan komunikasi interpersonal pada siswa kelas X SMAN 1 Tanjurhalang. Penelitian ini menggunakan pendekatan kuantitatif dengan kuasi eksperimen pre-test dan post test control group design. Sampel penelitian diambil dengan teknik purposive sampling. Penelitian ini menggunakan 20 siswa sebagai sampel yang terbagi dalam dua kelas, 10 siswa sebagai kelas eksperimen dan 10 siswa sebagai kelas kontrol. Pada kelas eksperimen, diberikan proses layanan konseling kelompok 8 kali pertemuan. Setelah melakukan analisis data, ditarik kesimpulan bahwa layanan konseling kelompok efektif dalam meningkatkan komunikasi interpersonal pada siswa kelas X SMAN 1 Tanjurhalang
Penerapan terapi suportif dengan teknik bimbingan untuk mengurangi dorongan bunuh diri pada pasien skizofrenia
Authors: Pardede Sulastry 
Published: August 2017

Penelitian ini menyelidiki kondisi pasien skizofrenia tipe paranoid yang memiliki dorongan bunuh diri tinggi yang ditandai gejala depresi dan gangguan mental; putus asa dan merasa tidak berdaya; kejadian negatif dalam hidup; isolasi sosial; disfungsi keluarga; kurang memahami makna hidup; dan penerimaan diri negatif. Tujuan penelitian ini yaitu untuk mengetahui gambaran klinis dan penerapan terapi suportif dengan teknik bimbingan untuk mengurangi dorongan bunuh diri pada pasien skizofrenia. Metode penelitian yang digunakan dalam penelitian ini adalah single case design. Pengumpulan data menggunakan observasi, wawancara dan tes psikologi diantaranya adalah Wechsler-Bellevue Intelligence Scale, Sack’s Sentence Completion Test, Grafis, Minnesota Multiphasic Personality Inventory dan intervensi terapi suportif dengan teknik bimbingan. Hasil intervensi menunjukkan berkurangnya dorongan bunuh, di perkuat dengan hasil pre test 9 termasuk dalam kategori medium Intent, sedangkan skor post-test yaitu 3 termasuk kedalam kategori low intent dengan Suicide Intent Scale . Prognosis pada subyek: positif, dimana dorongan bunuh diri berkurang.
Mental health status of workers in selected tea estates, Tamil Nadu, India
Authors: Ashwini G.S. , Ramesh Naveen , Navya C.J. , Joy J. , Thomas A. , Jyoti S. 
Published: August 2017

Introduction: The prevalence of mental illnesses among industrial workers ranged between 14% - 51%, which is more than that of the general population. Individual’s psychosocial functioning has an impact on the work efficiency and hence the current study was undertaken to screen workers in tea plantations.Objective: To document the prevalence of probable mental illness and its associated factors among workers in selected tea estates in South India.Methodology: A cross sectional study was done in two tea estates in Tamil Nadu from March to May 2012. The General Health Questionnaire (GHQ) 28 was used to screen for mental health status. Socio-demographic details, work profile and associated risk factors were also documented.Results: Among the 400 subjects interviewed, 75.5% were females. The mean age was 43.21 (±7.47) years and the mean work experience was 21.38 (±9.31) years. In this study 12.8% subjects screened positive for probable mental illness and 1%, 1%, 0.2% and 1.5% screened positive for the domains of somatic symptoms, anxiety/insomnia, social dysfunction and severe depression respectively. Workers who screened positive for probable mental illness had availed significantly greater duration of leave in the previous year. There was no significant association of mental illness with age, gender, marital status, substance abuse, designation, co-morbidity and stressful life events.Conclusion: The prevalence of probable mental illness was similar to other occupational settings. Management of the associated risk factors may improve one’s work efficiency and productivity.
A Preliminary Investigation into Multiple Pollutant Exposures and Nephrotoxicity Injury Among Goldsmiths
Authors: Shahajahan Sulthana , Ravichandran B , Reddy Shreedhar , Sen Somnath , Shruthi B.R. 
Published: August 2017

Background: Goldsmiths are known for using potent toxic chemicals which pose a health risk to workers which occur either by inhalation or by dermal contact. Chemicals taken up by the body causes damage to vital organs of body such as kidneys, lungs etc., there by affecting their normal physiology and function. Objective: Present study reports the assessment of Nephrotoxicity among goldsmiths who are employed from 4 years-50years in jewellery making units. Methods: The study involved various environmental parameters such as determination of TSPM for air pollutant analysis, biological parameters such as urinary β-2-microglobulin, urinary Creatinine, urinary albumin, urinary total protein concentrations, and serum concentrations of Glutathione-S-Transferase, Catalase, extracellular Super Oxide Dismutase and total protein in both control and test samples.Result: Environmental, biological parameters of exposure and renal dysfunction were examined in a group of goldsmith workers (n=22) and in an un-exposed control group (n=22).The parameters examined were compared between the two groups and related to different exposure parameters. The TSPM concentrations ranged between 75-664 µg/m3. The concentrations of β-2-microglobulin were 0.14-1.2 mg/g of Creatinine, In exposed group Serum concentration of Glutathione-S-Transferase was 1.19 ± 0.48, Catalase 5.1 ± 0.61, extracellular Super Oxide Dismutase 281.2 ± 90.8, and total protein 5.9 ±0.83. However there were no significant changes in the urinary albumin and urinary total protein concentrations between the exposed and the control population.
Four new species of Aleiodes (Hymenoptera: Braconidae: Rogadinae) from the Neotropical Region
Authors: Sulca Garro Lidia , Shimbori Eduardo Mitio , Penteado-Dias Angélica Maria , Shaw Scott Richard 
Published: August 2017

AbstractFour new species of the Aleiodes apicalis (Brullé) species group (Hymenoptera: Braconidae: Rogadinae) from the Neotropical Region are described and illustrated: Aleiodes ambrosiaenew species. from Peru, A. aquilesinew species from Costa Rica, and A. sachambrosiaenew species and A. tapirapenew species from Brazil. We also add new distribution records for Aleiodes molestus Cresson, from Costa Rica. With the addition of the new species, the A. apicalis species group has 11 species from the New World, six of which are recorded from Neotropical Region.
Epigeal phase of the biological cycle of Forficula auricularia Linnaeus (Dermaptera: Forficulidae) in eastern Canada
Authors: Tourneur Jean-Claude 
Published: August 2017

AbstractThe population structure of the European earwig, Forficula auricularia Linnaeus (Dermaptera: Forficulidae), was investigated in three sites in eastern Canada (Montréal, Québec; Fredericton, New Brunswick; Truro, Nova Scotia), with two goals; describe the seasonal trends of the epigeal phase, and ascertain if the three studied populations belong to sibling species “A”, as opposed to sibling species “B” found in Vancouver, British Columbia, Canada. Insects were collected using wooden grooved traps placed on lawns and tree trunks; traps were checked weekly from the first spring melt of the frost barrier until after autumn first frost (epigeal phase). The epigeal phase was short, about five months. The different instars and adults showed a single peak of abundance. No first instars, few second instars, and mostly fourth instars and adults were collected in the arborescent stratum. The data demonstrated that these three populations have the same epigeal phenology. The interbreeding experiment established that the three studied populations belong to the same sibling species (A) of F. auricularia, and differ from sibling species (B) from Vancouver. I suggest that the climatic conditions in eastern Canada are like those in other world regions where sibling species “A” is present, and that these regions represent the edge of the bioclimatic environment of this species because of its limits on reproduction.
Ontslag vanwege een hoofddoek; de arresten Achbita en Bougnaoui en de Nederlandse rechtspraktijk
Authors: Swarte A. , Loof J.P. 
Published: August 2017

Ontslag vanwege een hoofddoek; de arresten Achbita en Bougnaoui en de Nederlandse rechtspraktijk
Het Hof van Justitie heeft zich op 14 maart 2017 in twee verschillende zaken uitgesproken over het ontslag van een vrouwelijke werknemer vanwege het dragen van een islamitische hoofddoek. Naar beide arresten werd al enige tijd met spanning uitgekeken, onder meer vanwege de eerder gepubliceerde volkomen uiteenlopende conclusies van advocaten-generaal Kokott en Sharpston. Het Hof van Justitie lijkt veel ruimte te laten aan werkgevers om het dragen van religieuze symbolen op de werkplek te verbieden, mits zo’n verbod op een algemene en neutrale manier geformuleerd wordt. Er blijven echter veel vragen onbeantwoord en daardoor is onduidelijk hoe richtinggevend de arresten nu precies zijn.HvJ 14 maart 2017, zaak C-157/15, Samira Achbita/G4S Secure Solutions NV, ECLI:EU:C:2017:203 en zaak C-188/15, Asma Bougnaoui/Micropole SA, ECLI:EU:C:2017:204
Population size, center–periphery, and seed dispersers’ effects on the genetic diversity and population structure of the Mediterranean relict shrub Cneorum tricoccon
Authors: Lázaro‐Nogal Ana , Matesanz Silvia , García‐Fernández Alfredo , Traveset Anna , Valladares Fernando 
Published: August 2017

AbstractThe effect of population size on population genetic diversity and structure has rarely been studied jointly with other factors such as the position of a population within the species’ distribution range or the presence of mutualistic partners influencing dispersal. Understanding these determining factors for genetic variation is critical for conservation of relict plants that are generally suffering from genetic deterioration. Working with 16 populations of the vulnerable relict shrub Cneorum tricoccon throughout the majority of its western Mediterranean distribution range, and using nine polymorphic microsatellite markers, we examined the effects of periphery (peripheral vs. central), population size (large vs. small), and seed disperser (introduced carnivores vs. endemic lizards) on the genetic diversity and population structure of the species. Contrasting genetic variation (HE: 0.04–0.476) was found across populations. Peripheral populations showed lower genetic diversity, but this was dependent on population size. Large peripheral populations showed high levels of genetic diversity, whereas small central populations were less diverse. Significant isolation by distance was detected, indicating that the effect of long‐distance gene flow is limited relative to that of genetic drift, probably due to high selfing rates (FIS = 0.155–0.887), restricted pollen flow, and ineffective seed dispersal. Bayesian clustering also supported the strong population differentiation and highly fragmented structure. Contrary to expectations, the type of disperser showed no significant effect on either population genetic diversity or structure. Our results challenge the idea of an effect of periphery per se that can be mainly explained by population size, drawing attention to the need of integrative approaches considering different determinants of genetic variation. Furthermore, the very low genetic diversity observed in several small populations and the strong among‐population differentiation highlight the conservation value of large populations throughout the species’ range, particularly in light of climate change and direct human threats.
Pride and punishment: Entitled people's self‐promoting values motivate hierarchy‐restoring retribution
Authors: Redford Liz , Ratliff Kate A. 
Published: August 2017

AbstractWhat is the purpose of punishment? The current research shows that for entitled people—those with inflated self‐worth—justice is about maintaining societal hierarchies. Entitled people more strongly hold self‐enhancing values (power and achievement; Studies 1 and 3). They are also more likely, when thinking about justice for offenders, to adopt a hierarchy‐based justice orientation: Perceptions that crime threatens hierarchies, motives to restore those hierarchies, and support for retribution (Studies 2 and 3). Further, the relationship of entitlement to justice orientation is mediated by self‐enhancing values when entitlement is measured (Study 3) and manipulated (Studies 4, 5 and 6). Together these studies suggest that entitlement—and the resultant preoccupation with one's status—facilitates a view of justice as a hierarchy‐based transaction: one where criminal offenders and their victims exchange power and status. These findings reveal the self‐enhancing and hierarchy‐focused nature of entitlement, as well as the roots of retribution in concerns about status, power, and hierarchies.
Postcolumn determination of polyphenolic antioxidants in Cirsium vulgare (Savi) Ten. extracts
Authors: Nalewajko‐Sieliwoniuk Edyta , Malejko Julita , Twarowska Paulina , Timoszuk Magdalena , Nazaruk Jolanta 
Published: August 2017

AbstractNovel methods for the determination of polyphenolic antioxidants present in extracts from inflorescences of Cirsium vulgare (Savi) Ten. based on ultra‐high performance liquid chromatography with photodiode array and chemiluminescence detection have been developed. Under the optimized conditions of chromatographic separation the analytical characteristic of the method was performed. The proposed method was successfully applied to the determination of ten polyphenols present in inflorescences of Cirsium vulgare. A comparison of the contents of analytes in extracts prepared by using various extraction media (methanol, ethanol, 70% methanol, 70% ethanol, and water) was carried out for the first time. For the postcolumn detection of scavenging activity of polyphenolic antioxidants against reactive oxygen species (H2O2, •OH, O2• −) three systems based on chemiluminescence of luminol were used. A review of the current scientific literature shows that this is the first report on the application of luminol‐based postcolumn detection for the on‐line investigation of •OH scavenging activity. The main compound determined in extracts from inflorescences of Cirsium vulgare was apigenin 7‐O‐glucuronide, whereas the highest antioxidant activity was observed for chlorogenic acid, luteolin 7‐O‐glucoside, and apigenin.
Tremor Secondary to a Thalamic Glioma: A Case Report
Authors: Wang Tony R , Fadul Camilo E , Elias W Jeff 
Published: August 2017

Abstract

BACKGROUND AND IMPORTANCE
Tremor is the most prevalent movement disorder. While the exact pathophysiology remains to be elucidated, the importance of the thalamus in tremor circuitry is well recognized. Thalamic lesions from demyelination, trauma, ischemia, or neoplasm rarely cause isolated tremor. We report the case of a patient presenting with a tremor secondary to a thalamic grade II astrocytoma that improved with treatment.

CLINICAL PRESENTATION
A 50-yr-old male presented with a 1-yr history of right-hand tremor. The presence of long tract signs prompted imaging that revealed a lesion within the left thalamus. Stereotactic biopsy revealed a World Health Organization grade II astrocytoma. Prior to biopsy, the patient's tremor was graded using the Clinical Rating Scale for Tremor. Immediately postoperatively the patient remained at his neurological baseline without improvement in his tremor. Subsequent fractionated radiotherapy with concomitant temozolomide followed by adjuvant temozolomide led to radiographic response as well as clinical improvement. The patient reported less tremor, which was confirmed objectively with improved Clinical Rating Scale for Tremor scores at 6 and 12 mo postoperatively.

CONCLUSION
This case of a thalamic glioma presenting with isolated contralateral tremor highlights the role of the thalamus in the development of tremor. Moreover, this particular case contrasts with other published reports on the lack of additional symptoms and tremor response to chemoradiation.