bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Authors: Zhan Yang , Zhang Guanyi , Wang Xiaojie , Qi Yanfeng , Bai Shanshan , Li Dongying , Ma Tianfang , Sartor Oliver , Flemington Erik K. , Zhang Haitao , Lee Peng , Dong Yan 
Published: September 2016

Abstract
Androgen receptor splice variants (AR-V) are implicated in resistance of prostate cancer to androgen-directed therapies. When expressed alone in cells, some AR-Vs (e.g., AR-V7) localize primarily to the nucleus, whereas others (e.g., AR-V1, AR-V4, and AR-V6) localize mainly to the cytoplasm. Significantly, the latter are often coexpressed with the nucleus-predominant AR-Vs and the full-length AR (AR-FL). An important question to be addressed is whether the cytoplasmic-localized AR-Vs play a role in castration-resistant prostate cancer (CRPC) through interaction with the nucleus-predominant AR-Vs and AR-FL. Here, it is demonstrated that AR-V1, -V4, and -V6 can dimerize with both AR-V7 and AR-FL. Consequently, AR-V7 and androgen-bound AR-FL induced nuclear localization of AR-V1, -V4, and -V6, and these variants, in turn, mitigated the ability of the antiandrogen enzalutamide to inhibit androgen-induced AR-FL nuclear localization. Interestingly, the impact of nuclear localization of AR-V4 and -V6 on AR transactivation differs from that of AR-V1. Nuclear localization leads to an increased ability of AR-V4 and -V6 to transactivate both canonical AR targets and AR-V–specific targets and to confer castration-resistant cell growth. However, although AR-V1, which lacks inherent transcriptional activity, appears to activate AR-FL in an androgen-independent manner, it significantly antagonizes AR-V7 transactivation. Together, these data demonstrate that the complex interactions among different AR-Vs and AR-FL play a significant role in castration-resistant disease.
Implications: This study suggests important consequences for clinical castration resistance due to simultaneous expression of AR-FL and AR-Vs in patient tumors and suggests that dissecting these interactions should help develop effective strategies to disrupt AR-V signaling. Mol Cancer Res; 15(1); 59–68. ©2016 AACR.
A sighting of Plastingia naga (de Nicéville, [1884]) (Lepidoptera: Hesperiidae: Hesperiinae) from central Assam, India
Authors: Das Gaurab Nandi , Payra Arajush , Boruah Bitupan 
Published: September 2016

The species Plastingia naga, de Niceville 1884is a very rare butterfly, and it occurs widely from Assam to Myanmar, Malay Peninsula, Sumatra, Borneo and Philippines (Evans, 1932). Except India, recently this species was recorded from Singapore, Sumatra and Thailand. On 10 Oct 2014 around 10:00hr, a solitary individual of Plastingia naga was sighted in Panbari Reserve Forest, Central Assam. Apart from the fact that these records constitute existence of this species in North-East India, this is probably the first photographic record from North-East India.
Reduced Cognitive Control Demands after Practice of Saccade Tasks in a Trial Type Probability Manipulation
Authors: Pierce Jordan E. , McDowell Jennifer E. 
Published: September 2016

Abstract
Cognitive control is engaged to facilitate stimulus–response mappings for novel, complex tasks and supervise performance in unfamiliar, challenging contexts—processes supported by pFC, ACC, and posterior parietal cortex. With repeated task practice, however, the appropriate task set can be selected in a more automatic fashion with less need for top–down cognitive control and weaker activation in these brain regions. One model system for investigating cognitive control is the ocular motor circuitry underlying saccade production, with basic prosaccade trials (look toward a stimulus) and complex antisaccade trials (look to the mirror image location) representing low and high levels of cognitive control, respectively. Previous studies have shown behavioral improvements on saccade tasks after practice with contradictory results regarding the direction of functional MRI BOLD signal change. The current study presented healthy young adults with prosaccade and antisaccade trials in five mixed blocks with varying probability of each trial type (0%, 25%, 50%, 75%, or 100% anti vs. pro) at baseline and posttest MRI sessions. Between the scans, participants practiced either the specific probability blocks used during testing or only a general 100% antisaccade block. Results indicated an overall reduction in BOLD activation within pFC, ACC, and posterior parietal cortex and across saccade circuitry for antisaccade trials. The specific practice group showed additional regions including ACC, insula, and thalamus with an activation decrease after practice, whereas the general practice group showed a little change from baseline in those clusters. These findings demonstrate that cognitive control regions recruited to support novel task behaviors were engaged less after practice, especially with exposure to mixed task contexts rather than a novel task in isolation.
A new genus of millipedes (Diplopoda: Polydesmida: Dalodesmidae) from Tasmania, Australia with a mosaic distribution
Authors: MESIBOV ROBERT 
Published: September 2016

Atrophotergum silvaticum n. gen., n. sp. (type species), A. bonhami n. sp., A. montanum n. sp., A. pastorale n. sp., A sodalis n. sp., and A. wurrawurraense n. sp., are described. The six species have a tightly fitted mosaic distribution in Tasmania. Atrophotergum species are among the 'head + 19 segments' Australasian dalodesmids witha conspicuous pit on the underside of somite 2 in males, and relatively small metatergites on somites 3 and 4 in both sexes. The solenomerite in Atrophotergum is carried on a large posterior projection arising midway along the telopodite.
Diurnal Sea Breezes Force Near-Inertial Waves along Rottnest Continental Shelf, Southwestern Australia
Authors: Mihanović Hrvoje , Pattiaratchi Charitha , Verspecht Florence 
Published: September 2016

AbstractObservations of upper-ocean dynamics close to the critical latitude (ratio of the local inertial to diurnal frequency is 0.94) from a range of platforms (surface currents using HF radar, moored instruments, and satellite remote sensing data) off southwest Australia indicated the presence of energetic, near-inertial waves generated through the diurnal–inertial resonance. During the austral summer, when southerly winds and land–sea breeze (LSB) system dominated the wind regime, strong counterclockwise diurnal motions (amplitudes surpassing 0.3 m s−1) penetrated to 300-m depth with diurnal vertical isotherm fluctuations up to 60 m. The upward phase propagation speed of ~140 m day−1, deep penetration of diurnal currents below the mixed layer, and the ~180° phase difference between the upper and lower water column suggested that the local LSB system caused the resonant diurnal motions. Relative vorticity fluctuations along two cross-shore transects indicated changes to the local effective Coriolis frequency by more than 50% (±0.5f). In the presence of strong and relatively consistent cross-shore diurnal wind forcing in the study area, the main factors that controlled the observed energetic but sporadic near-inertial oscillations were the Leeuwin Current strength and spatial–temporal variations. These variations controlled the effective Coriolis frequency and enabled the effective pumping of diurnal wind energy into the ocean particularly when the effective Coriolis frequency was ~24 h.
Climatologically Significant Effects of Some Approximations in the Bulk Parameterizations of Turbulent Air–Sea Fluxes
Authors: Brodeau Laurent , Barnier Bernard , Gulev Sergey K. , Woods Cian 
Published: September 2016

AbstractThis paper quantifies the impacts of approximations and assumptions in the parameterization of bulk formulas on the exchange of momentum, heat, and freshwater computed between the ocean and atmosphere. An ensemble of sensitivity experiments is examined. Climatologies of wind stress, turbulent heat flux, and evaporation for the period 1982–2014 are computed using SST and surface meteorological state variables from ERA-Interim. Each experiment differs from the defined control experiment in only one aspect of the parameterization of the bulk formulas. The wind stress is most sensitive to the closure used to relate the neutral drag coefficient to the wind speed in the bulk algorithm, which mainly involves the value of the Charnock parameter. The disagreement between the state-of-the-art algorithms examined is typically on the order of 10%. The largest uncertainties in turbulent heat flux and evaporation are also related to the choice of the algorithm (typically 15%) but also emerge in experiments examining approximations related to the surface temperature and saturation humidity. Thus, approximations for the skin temperature and the salt-related reduction of saturation humidity have a substantial impact on the heat flux and evaporation (typically 10%). Approximations such as the use of a fixed air density, sea level pressure, or simplified formula for the saturation humidity lead to errors no larger than 4% when tested individually. The impacts of these approximations combine linearly when implemented together, yielding errors up to 20% over mid- and subpolar latitudes.
Characterization of Bias of Advanced Himawari Imager Infrared Observations from NWP Background Simulations Using CRTM and RTTOV
Authors: Zou X. , Zhuge X. , Weng F. 
Published: September 2016

AbstractStarting in 2014, the new generation of Japanese geostationary meteorological satellites carries an Advanced Himawari Imager (AHI) to provide the observations of visible, near infrared, and infrared with much improved spatial and temporal resolutions. For applications of the AHI measurements in numerical weather prediction (NWP) data assimilation systems, the biases of the AHI brightness temperatures at channels 7–16 from the model simulations are first characterized and evaluated using both the Community Radiative Transfer Model (CRTM) and the Radiative Transfer for the TIROS Operational Vertical Sounder (RTTOV). It is found that AHI biases under a clear-sky atmosphere are independent of satellite zenith angle except for channel 7. The biases of three water vapor channels increase with scene brightness temperatures and are nearly constant except at high brightness temperatures for the remaining infrared channels. The AHI biases at all the infrared channels are less than 0.6 and 1.2 K over ocean and land, respectively. The differences in biases between RTTOV and CRTM with the land surface emissivity model used in RTTOV are small except for the upper-tropospheric water vapor channels 8 and 9 and the low-tropospheric carbon dioxide channel 16. Since the inputs used for simulations are the same for CRTM and RTTOV, the differential biases at the water vapor channels may be associated with subtle differences in forward models.
Repeat Imaging in Idiopathic Unilateral Vocal Fold Paralysis
Authors: Noel Julia E. , Jeffery Caroline C. , Damrose Edward 
Published: September 2016

Objective: Imaging plays a critical role in the evaluation of patients presenting with unilateral vocal fold paresis or paralysis of unknown etiology. In those with idiopathic unilateral vocal fold paralysis (iUVFP), there is no consensus regarding the need or timing of repeat imaging. This study seeks to establish the rate of delayed detection of alternate etiologies for these patients to determine if and when imaging should be repeated. Methods: Retrospective chart review was conducted identifying patients at our institution with vocal fold movement impairment between 1998 and 2014. Idiopathic paralysis was diagnosed if physical examination, laryngoscopy, and initial imaging excluded a cause. Demographic data, length of follow-up, and the presence of late lesions were noted. Time to detection was plotted using the Kaplan-Meier method. Results: Of 3210 patients reviewed, 207 had a diagnosis of iUVFP. Of these patients, 8 went on to develop alternate diagnoses, including pulmonary disease, skull-base and laryngeal neoplasms, and thyroid malignancy. In Kaplan-Meir analysis, 90% remained “idiopathic” at 5 years of follow-up. The mean time to detection was 27 months. Conclusions: Patients initially diagnosed with iUVFP may have an occult cause that later becomes evident. We recommend repeat imaging within 2 years after diagnosis, but this is likely unnecessary beyond 5 years.
‘The horse has bolted I suspect’: A qualitative study of clinicians’ attitudes and perceptions regarding palliative rehabilitation
Authors: Runacres Fiona , Gregory Heidi , Ugalde Anna 
Published: September 2016

Background: Palliative care patients have numerous rehabilitation needs that increase with disease progression. Palliative rehabilitation practices and perceptions of palliative medicine physicians towards the role of rehabilitation are largely unstudied. Aim: To explore palliative medicine physicians’ attitudes and perceptions towards rehabilitation delivered within inpatient palliative care units. Design: Qualitative study utilizing semi-structured interviews. Transcribed interviews were analysed using thematic analysis and major themes reported as results. Participants: Australian palliative medicine physicians working in inpatient palliative care units. Results: In total, 20 physicians participated, representing specialist palliative care services across Australia. A total of 11 (55%) were males with an average of 12.5 years’ experience working in palliative care. Most participants believed rehabilitation was an important aspect of palliative care; however, few felt adequate rehabilitation programmes were available. Participants varied in their concepts of what palliative rehabilitation entailed. The term rehabilitation was seen by some as helpful (fostering hope and aiding transitions) and by others to be misleading (creating unrealistic expectations). Four key themes emerged when describing physicians’ attitudes, including (1) integrating rehabilitation within palliative care, (2) the intervention, (3) possibilities and (4) the message of rehabilitation. Conclusion: A lack of consensus exists among palliative medicine specialists regarding the definition and scope of palliative rehabilitation. Participants generally expressed a wish to offer enhanced rehabilitation interventions, however described resource and skill-set limitations as significant barriers. Further research is required to establish an evidence base for palliative rehabilitation, to support its acceptance and widespread integration within specialist inpatient palliative care.
Effectiveness of Headless Bioabsorbable Screws for Fixation of the Scarf Osteotomy
Authors: Kim Jin su , Cho Hun ki , Young Ki Won , Lee Sang young , Kim Ji soo , Lee Kyoungtae 
Published: September 2016

Background: Scarf osteotomy has been used in hallux valgus surgery due to its large fixation surface for screws and low postoperative complications. However, screws may cause skin irritation from their head, which may require an additional surgical procedure to remove. Methods: This study included 115 patients (106 females and 9 males, 115 feet) who underwent hallux valgus correction with a scarf osteotomy using bioabsorbable screws between September 2010 and September 2012. Preoperative and postoperative 1-month and 1-year radiographic measurements, including intermetatarsal angle (IMA), hallux valgus angle (HVA), distal metatarsal articular angle (DMAA), proximal phalangeal articular angle (PPAA), and lateral translational distance (LTD), were obtained. American Orthopaedic Foot & Ankle Society (AOFAS) hallux/forefoot scores were used for patient satisfaction. Results: Preoperative mean values of HVA, IMA, and PPA of 32.8 degrees, 14.6 degrees, and 7.52 degrees, respectively, improved to 10.7 degrees, 6.0 degrees, and 4.6 degrees, respectively at 1-year follow up ( P < .05). The difference in LTD between the 1-month and 1-year follow-up was not statistically significant. AOFAS hallux/forefoot score improved from 69.1 to 96.1 at the 1-year follow up ( P < .001). Complete screw absorption was not seen radiographically. Sixteen feet had complications reported. One patient complained of skin irritation over a small protrusion of the screw, and another patient had a foreign body reaction. There were 3 patients with neurologic injury from a popliteal block and 3 patients with dorsal cutaneous nerve symptoms. Four feet had metatarsal fracture during surgery. Conclusion: We found the scarf osteotomy using bioabsorbable screws to have satisfactory clinical and radiographic results with a low complication rate. Level of Evidence: Level IV, case series.
Realtime Achilles Ultrasound Thompson (RAUT) Test for the Evaluation and Diagnosis of Acute Achilles Tendon Ruptures
Authors: Griffin Matthew J. , Olson Kirstina , Heckmann Nathanael , Charlton Timothy P. 
Published: September 2016

Background: Acute complete Achilles tendon ruptures are commonly missed injuries. We propose the Realtime Achilles Ultrasound Thompson (RAUT) test, a Thompson test under ultrasound visualization, to aid in the diagnosis of these injuries. We hypothesized that RAUT testing would provide improved diagnostic characteristics compared with static ultrasound. Methods: Twenty-two consecutive patients with operatively confirmed acute Achilles tendon ruptures were prospectively evaluated with RAUT testing and static ultrasonography. RAUT video recordings and static ultrasound images from both ruptured and uninjured sides were randomized and graded by a group of novice reviewers and a group of expert attendings. From these observations, sensitivity, specificity, positive predictive value, and negative predictive value for RAUT and static ultrasound were calculated. In addition, κ interobserver coefficients were computed. Forty-seven novice reviewers and 11 foot and ankle attendings made a total of 4136 and 528 observations, respectively. Results: For static ultrasound, sensitivity and specificity were 76.8% and 74.8% for the novice reviewers and 79.6% and 86.4% for the attendings, respectively. For RAUT testing, sensitivity and specificity were 87.2% and 81.1% for the novice group and 86.4% and 91.7% for the attending group, respectively. The κ coefficient was 0.62 and 0.27 for novice and attending RAUT reviewers, indicating substantial and fair agreement, respectively, but only 0.46 and 0.12 for static ultrasonography, representing moderate and slight agreement, respectively. Conclusion: RAUT testing was a sensitive and specific test, providing a cost-effective adjunct to the clinical examination when diagnosing acute Achilles tendon ruptures. This test can be used by surgeons with minimal training in ultrasonography. Level of Evidence: Level II, diagnostic study.
Perforator-based propeller flaps reliability in upper extremity soft tissue reconstruction: a systematic review
Authors: Vitse J. , Bekara F. , Bertheuil N. , Sinna R. , Chaput B. , Herlin C. 
Published: September 2016

Current data on upper extremity propeller flaps are poor and do not allow the assessment of the safety of this technique. A systematic literature review was conducted searching PubMed, EMBASE, and the Cochrane Library electronic databases, and the selection process was adapted from the preferred reporting items for systematic reviews and meta-analysis statement. The final analysis included ten relevant articles involving 117 flaps. The majority of flaps were used for the hand, distal wrist, and elbow. The radial artery perforator and ulnar artery perforator were the most frequently used flaps. The were 7% flaps with venous congestion and 3% with complete necrosis. No difference in complications rate was found for different flaps sites. Perforator-based propeller flaps appear to be an interesting procedure for covering soft tissue defects involving the upper extremities, even for large defects, but the procedure requires experience and close monitoring. Level of evidence: II
Relationship between Metabolic Syndrome and Number of Teeth in Japan
Authors: Kawashita Y. , Kitamura M. , Ando Y. , Saito T. 
Published: September 2016

The 2004 Japanese National Health and Nutrition Survey collected data on several measures, including self-reported dental health. In addition, this was the first nationwide survey to focus on metabolic syndrome (MetS) in Japan. Therefore, the authors used this nationwide data set to assess the relationship between number of teeth present and MetS. Anonymized data were available with permission from the Ministry of Health, Labour and Welfare of Japan. Data from 3,195 men and women aged 35 to 99 y were examined, and logistic regression analyses were used to evaluate the association between number of teeth and MetS. Moreover, the authors performed an analysis of covariance to compare the mean number of teeth between those with and those without MetS, after adjusting for confounders. In comparison with those having ≥28 teeth, those with fewer remaining teeth demonstrated significantly higher odds of having MetS. Specifically, those having 1 to 9 teeth had higher odds of having MetS than those with more teeth and were more than twice as likely to be affected than those with ≥28 teeth. Furthermore, individuals with MetS in the age groups of 45 to 54, 55 to 64, and 65 to 74 y had significantly fewer teeth than those without MetS in the same age groups. These results suggest that the number of teeth present is associated with the prevalence of MetS in the Japanese population. Knowledge Transfer Statement: The results of this study can be used by clinicians when they examine patients with periodontal disease or extensive tooth loss to refer for a general medical examination.
Pulmonary rehabilitation
Authors: Wouters E.F.M. 
Published: September 2016

Educational aimsTo provide insights into management goals of pulmonary rehabilitation.To provide information about the structure and setting-up of pulmonary rehabilitation programmes.To provide information to health providers about the outcome of non-pharmacological treatment programmes.SummaryPulmonary rehabilitation programmes in chronic respiratory diseases have clear effects on improvements in exercise tolerance, reduction of symptoms such as dyspnoea and of health-related quality of life. Further studies are needed in order to define the long-term benefits as well as the optimal programme structure to get the greatest effects. Cost-effectiveness studies are needed, as well as data on more optimal selection procedures, in order to select the best possible candidates for rehabilitation. Exercise training programmes have to integrate present knowledge of muscular adaptations in patients with chronic respiratory diseases as COPD. The shift from empiricism to science in performing pulmonary rehabilitation may result not only in a further improvement in quality of life, but perhaps also in life expectancy for patients with usually incurable and sometimes inexorably progressive pulmonary disease.