bluuebunny/crossref_metadata_2025_split huggingface dataset:
Open versus Endoscopic Medial Orbital Decompression: Utilization, Cost, and Operating Room Time
Authors: Ference Elisabeth H. , Sindwani Raj , Tan Bruce K. , Chandra Rakesh K. , Kern Robert C. , Conley David , Smith Stephanie Shintani 
Published: September 2016

Background The advent of endoscopic sinus surgery has created an exciting interface between rhinology and ophthalmology in the area of orbital and optic nerve decompression Objectives (1) To study the utilization of open versus endoscopic medial orbital decompression based on geography and indication, (2) to describe the demographics of the patient populations who underwent these different techniques, and (3) to compare outcomes, including mean charges and operating room (OR) times Methods Cases identified by Current Procedural and Terminology codes were extracted from the California, Florida, Maryland, and New York State Ambulatory Surgery Databases from 2009 to 2011. Patient demographics, diagnoses, mean charge, and OR time were compared. Results A total of 1009 patients underwent orbital decompression; 93.0% of cases involved the medial wall only; 22.9% of medial decompressions were performed endoscopically, 74.5% were open, and 2.6% were via combined approach. Eighty percent of patients had thyroid eye disease. Analyses adjusted for sex, age, race, state, and diagnosis found that surgeries for infection (N = 47) were more likely to be performed endoscopically compared with procedures for other diagnoses (N = 962) (odds ratio 5.27 [2.67-10.40], p < 0.001). Patients in Florida were more likely to undergo endoscopic decompression compared with patients in California (odds ratio 2.35 [1.42-3.62]). The difference in median charge for endoscopic ($13,119) versus open ($11,291; p = 0.085) procedures was not significant on bivariate analysis but was significant on multivariate analysis (p = 0.04). The median OR time for open procedures was, on average, 33 minutes shorter (endoscopic, 132 minutes; open, 98 minutes; p ≤ 0.001) on bivariate analysis but was not significantly different when controlling for covariables (p = 0.08). Conclusion In the study sample, endoscopic orbital decompression was performed in 22.9% of patients, with significant variation in surgical technique based on geography and indication. Procedures that used endoscopic compared with open decompression techniques had no significant difference in charge on bivariate analysis. The OR time for open procedures was shorter on bivariate but not on multivariate analysis. Further research is required regarding the relative effectiveness of open versus endoscopic surgical techniques for various indications
Immunoglobulin G4-related Sclerosing Disease of the Paranasal Sinuses: A Case Report and Literature Review
Authors: Vandjelovic Nathan D. , Humphreys Ian M. 
Published: September 2016

Objective Immunoglobulin G4 (IgG4) related sclerosing disease (RSD) of the paranasal sinuses is a rare lesion of dense lymphoplasmacytic tissue, with a high proportion of IgG4+ plasma cells. We presented a rare case of IgG4-RSD with isolated involvement of the paranasal sinuses in the absence of multiorgan involvement. Methods A case report and comprehensive literature review. Results To our knowledge, only 11 cases of IgG4-RSD with paranasal sinus involvement have been reported. Patients with IgG4-RSD commonly present with epistaxis and symptoms that mimic chronic rhinosinusitis, e.g., rhinorrhea, nasal obstruction, and facial pressure. On imaging, an expansive and erosive process is described. Surgery provides tissue for immunohistologic evaluation; however, there is a paucity of evidence about the direct extent of surgical resection or medical therapies. Postoperative steroids were typically started, although the regimen was not standardized. Conclusion Few cases of paranasal sinus IgG4-RSD have been reported in the literature. Evidence-based recommendations regarding treatment and surveillance of paranasal sinus IgG4-RSD are lacking; however, most reports describe systemic steroids as the mainstay of treatment. This single subject analysis, with a review of previously reported cases adds to the expanding body of data related to this rare disorder.
The effects of stabilizing exercises on pain and disability of patients with lumbar segmental instability
Authors: Javadian Yahya , Behtash Hamid , Akbari Mohammad , Taghipour-Darzi Mohammad , Zekavat Hajar 
Published: September 2016

Background data: Lumbar segmental instability (LSI) is one of the subgroups of non-specific chronic low back pain. Pain, functional disability and reduced muscle endurance are common in such patients. Objective: The aim of this study was to determine the effects of stabilization exercise on pain, functional disability and muscle endurance in patients with LSI. Methods: A randomized clinical trial was carried out on 30 patients who had LSI aged between 18–45 years. They were divided into two groups; the control group underwent routine exercise only while the experimental group performed routine exercise plus stabilization training for 8 weeks. Both had 3 months follow-up. The variables included pain intensity, functional disability and flexion and extension range of motion and flexor, extensor and lateral flexor muscles endurance which were evaluated 3 times; before, post treatment and after three months. The data were analyzed using repeated measurement ANOVA. Results: The results revealed that after treatment, the trunk muscle endurance and flexion range of motion increased significantly and the pain intensity and functional disability decreased significantly in both groups; however the rate of improvement was significantly higher in the experimental group. The process of decreasing pain intensity and functional disability in addition to increasing muscle endurance time were significantly faster in the experimental group during the three months follow up. Conclusion: Regarding the positive effects of stabilizing exercises with routine exercises in reduction of pain intensity, increasing functional ability and muscle endurance, it is recommended to use this method in treatment of patients with lumbar segmental instability.
Spastic paraparesis and sensorineural hearing loss in a patient with neurobrucellosis
Authors: Baykal Tuba , Baygutalp Fatih , Senel Kazim , Levent Akin , Erdal Akin , Ugur Mahir , Ozgocmen Salih 
Published: September 2016

Objective: Brucellosis is a zoonotic disease and still a major public health problem in many geographic areas including Mediterranean basin and Middle East. Brucellosis causes multisystemic involvement and although rare central nervous system involvement causes serious manifestations. Neurobrucellosis occurs less than 5% of patients and presents with meningitis, encephalitis, myelitis, myelopathy, stroke, paraplegia, radiculoneuritis, intracerebral abscess, epidural abscess, demyelination and cranial nerve involvement or any combination of these manifestations. Spastic paraparesis and the sensorineural involvement are rarely reported in the literature. Methods: Herein we present a 28 years-old man with spastic paraparesis and sensorineural hearing loss due to neurobrucellosis. Results: The patient was treated with antibiotics combination for 6 months and underwent rehabilitation program. Conclusions: Neurobrucellosis should be ruled out in patients with unexplained neurological symptoms and/or sensorineural hearing loss particularly in those living in endemic areas.
A review of activity monitors as a new technology for objectifying function in lumbar spinal stenosis
Authors: Tomkins-Lane Christy C. , Haig Andrew J. 
Published: September 2016

The purpose of this review article is to introduce the concept of activity monitoring, and to discuss the application of accelerometry in rehabilitation research and clinical practice using lumbar spinal stenosis as a model. Function is a complex concept, and changes in function have historically been challenging to measure. The International Classification of Functioning (ICF) defines two distinct components of function: capacity and performance. Capacity, the ability to perform a given task in a controlled environment can be measured through any number of existing functional measures. Performance, defined as activities performed on a day to day basis in the context of real life is challenging to measure, yet important in identifying the impact of pathology on real life. Recent advances in technology have allowed us to begin to measure performance, using activity monitors (accelerometers). Activity monitoring has the potential to change our concepts of outcomes, and as a result, expand our ideas about appropriateness of interventions in rehabilitation. Researchers and clinicians might benefit from using the new technology of activity monitors to measure the impact of intervention and to assess function. Therefore, this review will discuss the concept of activity monitoring and highlight potential uses for activity monitors in spine research and clinical care.
Effect of scapular elevation taping on scapular depression syndrome: A case report
Authors: Lee Jung-Hoon , Yoo Won-Gyu 
Published: September 2016

Objective: This report describes the application of scapular elevation taping (SET) using kinesio tape to elevate the scapula and treat upper trapezius (UT) muscle tenderness in a patient with scapular depression syndrome. Methods: The patient was a 22-year-old man who had scapular depression and severe tenderness of the right UT. We performed SET for 2 months, 4 days a week, for an average of 9 h each day, to provide scapular elevation. Results: At the last assessment, the right superior angle of the scapula and the lateral border of the acromion were slightly elevated compared with the spinous process of the second thoracic vertebra. A chest X-ray showed that the right coracoid process was higher compared to the initial level and that the level of the first ribs was similar on both sides. The pressure-pain threshold in the UT increased from 1 to 8 kg and the tenderness at 3 kg, assessed on a numeric rating scale, decreased from 6 to 0. No tenderness occurred when carrying a bag with the right hand or slinging a bag over the right shoulder. Conclusion: Continuous application of SET may be used as a supplementary method for scapular elevation and reduction in patients with UT tenderness.
Risk Factors for Decline of Residual Renal Function in Children Treated with Peritoneal Dialysis
Authors: Roszkowska-Blaim Maria , Skrzypczyk Piotr 
Published: September 2016

Background The aim of the study was to assess risk factors for residual renal function (RRF) decline in children during the first/second year of chronic peritoneal dialysis (PD). Methods The study group included 56 children with end-stage renal disease (ESRD) (age 10.13 ± 4.86 years), including 18 on continuous ambulatory PD (CAPD) and 38 on automated PD (APD), in whom we evaluated RRF (daily diuresis [mL/m2/24 h], residual glomerular filtration rate (rGFR) [mL/min/1.73 m2]), etiology of ESRD, PD fluid volume (mL/m2/24 h), glucose load (g/m2/24 h), ultrafiltration (mL/m2/24 h), peritoneal permeability (D/PCrea 4h, D/D0 Glu 4h), dialysis adequacy (twKt/V, twCCr [L/week/1.73 m2]), blood pressure (BP), biochemical parameters, and medications used. Duration of follow-up was 24 months. Results Mean diuresis before initiation of PD was 1,394.93 ± 698.37 (mL/m2/24 h), and mean rGFR was 7.41 ± 3.96 (mL/min/1.73 m2). The rate of daily diuresis decline was -529.34 ± 546.28 in the first year and -107.10 ± 291.54 (mL/m2/24 h) in the second year ( p = 0.005), and the rate of rGFR decline was -3.35 ± 3.73 in the first year and -1.63 ± 1.85 (mL/min/1.73 m2) in the second year ( p = 0.118). Eleven (19.64%) patients became anuric. In univariate analysis, the rate of daily diuresis decline in the first year was related to baseline diuresis ( r = -0.29, p = 0.031), proteinuria ( r = -0.43, p = 0.001), and systolic BP ( r = -0.31, p = 0.020); 12-month changes (Δ0 - 12) in PD fluid volume ( r = -0.37, p = 0.004), glucose load ( r = -0.28, p = 0.035), and ultrafiltration ( r = -0.38, p = 0.004); serum calcium-phosphorus product ( r = -0.41, p = 0.002); and Δ0 - 12 body mass index (BMI) Z-score ( r = 0.30, p = 0.024); while the rate of rGFR decline in the first year was related only to baseline rGFR ( r = -0.57, p < 0.001). In multivariate analysis, significant predictors of the rate of daily diuresis decline in the first year were baseline diuresis (P = -0.386, p < 0.001) and proteinuria (p = -0.278, p = 0.017), mean systolic BP Z-score (P = -0.237, p = 0.027), and age at the onset of PD (P = -0.224, p = 0.037), while predictors of the rate of rGFR decline were baseline rGFR (P = -0.607, p < 0.001) and baseline proteinuria (P = -0.225, p = 0.046). In the second year, the only predictors of the rate of rGFR decline were D/D0 Glu 4h ( r = 0.44, p = 0.033, univariate analysis) and rGFR at 12 months (P = -0.499, p = 0.044). Conclusion The most important risk factors for rapid RRF decline in children during the first year of chronic PD include higher baseline daily diuresis and proteinuria, and additional factors are systolic BP and age at the onset of PD; while high baseline GFR and low peritoneal transport status may be the only important factors during the second year.
The Effect of Serum Sodium on Survival in Patients Treated by Peritoneal Dialysis in the United Kingdom
Authors: Al-Chidadi Asmaa , Nitsch Dorothea , Davenport Andrew 
Published: September 2016

Background Studies in hemodialysis patients suggest that hyponatremia is associated with increased mortality. However, results from peritoneal dialysis (PD) patients are discordant. We wished to establish whether there was an association between serum sodium and mortality risk in PD patients. Methods We analyzed 3,108 PD patients enrolled at day 90 of renal replacement therapy (RRT) into the UK Renal Registry (UKRR) data base with available serum sodium measurements (in 3 groups: ≤ 137, 138 - 140, ≥ 141 mmol/L) who were then followed up until death or the censoring date (31 December 2012). Analysis used Cox-regression with adjustment for age, sex, year of starting RRT, primary renal disease, serum albumin, smoking, and comorbidities. Results Unadjusted mortality rates were 118.6/1,000 person-years (py), 83.4/1,000 py, and 83.5/1,000 py for the lowest, middle, and highest serum sodium tertiles, respectively. After adjustment for covariates, patients in the lowest serum sodium group had almost 50% increased risk of dying compared with those with the highest serum sodium (hazard ratio [HR] 1.49, confidence interval [CI]:1.28 - 1.74), with a graded association between serum sodium and mortality. The association of serum sodium with mortality varied by age (p interaction < 0.001), and whilst this association attenuated after adjustment for confounding variables in the older age groups (55 - 64, and > 65 years), it remained in the younger age group of 18 - 54 years (HR 2.24 [1.36 – 3.70] in the lowest compared with the highest sodium tertile). Conclusions Lower serum sodium concentrations at the start of RRT in PD patients are associated with increased risk of mortality. Whilst this association may well be due to confounding in the older age groups, the persistent strong association between hyponatremia and mortality in the younger age group after adjustment for the available confounders suggests that prospective studies are required to assess whether active intervention to maintain serum sodium changes outcomes.
Compatibility of Meropenem with Different Commercial Peritoneal Dialysis Solutions
Authors: Wiesholzer Martin , Winter Alexandra , Kussmann Manuel , Zeitlinger Markus , Pichler Petra , Burgmann Heinz , Reznicek Gottfried , Poeppl Wolfgang 
Published: September 2016

Background Intraperitoneal administration of antimicrobial agents is recommended for the treatment of peritoneal dialysis (PD)-related peritonitis. For home-based antimicrobial therapy it is common to supply patients with PD fluid bags with admixed antibiotic. Thus, the compatibility of meropenem with different PD fluids (PDFs), namely Extraneal, Physioneal 1.36% and Physioneal 2.27% (all Baxter Healthcare Corp., Deerfield, IL, USA), was investigated under varying storage conditions. Methods Meropenem (Venus Pharma, Werne, Germany) was stored at 6°C and 25°C over 14 days and at 37°C over 24 hours. Drug concentration over time was determined using high performance liquid chromatography, drug activity by a diffusion disk method, diluent stability by visual inspection and drug adsorption was calculated. Blank PD fluids and deionized water were used as comparator solutions. Results Compared to water, the stability of meropenem was minimally lower in Extraneal but markedly reduced in both Physioneal solutions. No significant drug adsorption was detected for any PDF investigated. Conclusions Meropenem is stable and compatible with Extraneal and might be stored for up to a week at refrigeration temperature (6°C). A loss of ∼20% of meropenem after 2 days at room temperature should be considered. Mixed Physioneal appears not suitable for storage at any temperature after meropenem has been admixed. A considerable drug degradation due to the warming up to body temperature through heating plates should further be taken into account in clinical practice.
Early Peritonitis in A Large Peritoneal Dialysis Provider System in Colombia
Authors: Vargas Edgar , Blake Peter G. , Sanabria Mauricio , Bunch Alfonso , López Patricia , Vesga Jasmín , Buitrago Alberto , Astudillo Kindar , Devia Martha , Sánchez Ricardo 
Published: September 2016

Background Peritonitis is the most important complication of peritoneal dialysis (PD), and early peritonitis rate is predictive of the subsequent course on PD. Our aim was to calculate the early peritonitis rate and to identify characteristics and predisposing factors in a large nationwide PD provider network in Colombia. Methods This was a historical observational cohort study of all adult patients starting PD between January 1, 2012, and December 31, 2013, in 49 renal facilities in the Renal Therapy Services in Colombia. We studied the peritonitis rate in the first 90 days of treatment, its causative micro-organisms, its predictors and its variation with time on PD and between individual facilities. Results A total of 3,525 patients initiated PD, with 176 episodes of peritonitis during 752 patient-years of follow-up for a rate of 0.23 episodes per patient year equivalent to 1 every 52 months. In 41 of 49 units, the rate was better than 1 per 33 months, and in 45, it was better than 1 per 24 months. Peritonitis rates did not differ with age, ethnicity, socioeconomic status, or PD modality. We identified high incidence risk periods at 2 to 5 weeks after initiation of PD and again at 10 to 12 weeks. Conclusion An excellent peritonitis rate was achieved across a large nationwide network. This occurred in the context of high nationwide PD utilization and despite high rates of socioeconomic deprivation. We propose that a key factor in achieving this was a standardized approach to management of patients.
MEASURING TRANSIT SIGNAL RECOVERY IN THE KEPLER PIPELINE. III. COMPLETENESS OF THE Q1–Q17 DR24 PLANET CANDIDATE CATALOG WITH IMPORTANT CAVEATS FOR OCCURRENCE RATE CALCULATIONS
Authors: Christiansen Jessie L. , Clarke Bruce D. , Burke Christopher J. , Jenkins Jon M. , Bryson Stephen T. , Coughlin Jeffrey L. , Mullally Fergal , Thompson Susan E. , Twicken Joseph D. , Batalha Natalie M. , Haas Michael R. , Catanzarite Joseph , Campbell Jennifer R. , Uddin AKM Kamal , Zamudio Khadeejah , Smith Jeffrey C. , Henze Christopher E. 
Published: September 2016

ABSTRACT
With each new version of the Kepler pipeline and resulting planet candidate catalog, an updated measurement of the underlying planet population can only be recovered with a corresponding measurement of the Kepler pipeline detection efficiency. Here we present measurements of the sensitivity of the pipeline (version 9.2) used to generate the Q1–Q17 DR24 planet candidate catalog. We measure this by injecting simulated transiting planets into the pixel-level data of 159,013 targets across the entire Kepler focal plane, and examining the recovery rate. Unlike previous versions of the Kepler pipeline, we find a strong period dependence in the measured detection efficiency, with longer (>40 day) periods having a significantly lower detectability than shorter periods, introduced in part by an incorrectly implemented veto. Consequently, the sensitivity of the 9.2 pipeline cannot be cast as a simple one-dimensional function of the signal strength of the candidate planet signal, as was possible for previous versions of the pipeline. We report on the implications for occurrence rate calculations based on the Q1–Q17 DR24 planet candidate catalog, and offer important caveats and recommendations for performing such calculations. As before, we make available the entire table of injected planet parameters and whether they were recovered by the pipeline, enabling readers to derive the pipeline detection sensitivity in the planet and/or stellar parameter space of their choice.
MULTI-PHASE NATURE OF A RADIATION-DRIVEN FOUNTAIN WITH NUCLEAR STARBURST IN A LOW-MASS ACTIVE GALACTIC NUCLEUS
Authors: Wada Keiichi , Schartmann Marc , Meijerink Rowin 
Published: September 2016

ABSTRACT
The structures and dynamics of molecular, atomic, and ionized gases are studied around a low-luminosity active galactic nucleus (AGN) with a small (

2
×

10

6

M

⊙

) black hole using three-dimensional (3D) radiation–hydrodynamic simulations. We studied, for the first time, the non-equilibrium chemistry for the X-ray-dominated region in the “radiation-driven fountain” with supernova feedback. A double hollow cone structure is naturally formed without postulating a thick “torus” around a central source. The cone is occupied with an inhomogeneous, diffuse ionized gas and surrounded by a geometrically thick (

h

/

r
≳
1

) atomic gas. Dense molecular gases are distributed near the equatorial plane, and energy feedback from supernovae enhances their scale height. Molecular hydrogen exists in a hot phase (>1000 K) as well as in a cold (

<
100

K

), dense (

>

10

3

cm

−
3

) phase. The velocity dispersion of H2 in the vertical direction is comparable to the rotational velocity, which is consistent with near-infrared observations of nearby Seyfert galaxies. Using 3D radiation transfer calculations for the dust emission, we find polar emission in the mid-infrared band (12 μm), which is associated with bipolar outflows, as suggested in recent interferometric observations of nearby AGNs. If the viewing angle for the nucleus is larger than 75°, the spectral energy distribution is consistent with that of the Circinus galaxy. The multi-phase interstellar medium observed in optical/infrared and X-ray observations is also discussed.