bluuebunny/crossref_metadata_2025_split huggingface dataset:
Papillary Thyroid Carcinoma (PTC) in Children and Adults: Comparison of Initial Presentation and Long‐Term Postoperative Outcome in 4432 Patients Consecutively Treated at the Mayo Clinic During Eight Decades (1936–2015)
Authors: Hay Ian D. , Johnson Tammi R. , Kaggal Suneetha , Reinalda Megan S. , Iniguez‐Ariza Nicole M. , Grant Clive S. , Pittock Siobhan T. , Thompson Geoffrey B. 
Published: October 2017

AbstractBackgroundContemporary guidelines for managing PTC advise an approach wherein primary tumor and regional metastases (RM) are completely resected at first surgery and radioiodine remnant ablation (RRA) is restricted to high‐risk patients, policies our group has long endorsed. To assess our therapeutic efficacy, we studied 190 children and 4242 adults consecutively treated during 1936–2015.
Subjects and methodsMean follow‐up durations for children and adults were 26.9 and 15.2 years, respectively. Bilateral lobar resection was performed in 86% of children and 88% of adults, followed by RRA in 30% of children and 29% of adults; neck nodes were excised in 86% of children and 66% of adults. Tumor recurrence (TR) and cause‐specific mortality (CSM) details were taken from a computerized database.ResultsChildren, when compared to adults, had larger primary tumors which more often were grossly invasive and incompletely resected. At presentation, children, as compared to adults, had more RM and distant metastases (DM). Thirty‐year TR rates were no different in children than adults at any site. Thirty‐year CSM rates were lower in children than adults (1.1 vs. 4.9%; p = 0.01). Comparing 1936–1975 (THEN) with 1976–2015 (NOW), 30‐year CSM rates were similar in MACIS <6 children (p = 0.67) and adults (p = 0.08). However, MACIS <6 children and adults in 1976–2015 had significantly higher recurrence at local and regional, but not at distant, sites. MACIS 6+ adults, NOW, compared to THEN, had lower 30‐year CSM rates (30 vs. 47%; p < 0.001), unassociated with decreased TR at any site.ConclusionsChildren, despite presenting with more extensive PTC when compared to adults, have postoperative recurrences at similar frequency, typically coexist with DM and die of PTC less often. Since 1976, both children and adults with MACIS <6 PTC have a <1% chance at 30 years of CSM; adults with higher MACIS scores (6 or more) have a 30‐year CSM rate of 30%.
RNA Regulations and Functions Decoded by Transcriptome-Wide RNA Structure Probing
Authors: Piao Meiling , Sun Lei , Zhang Qiangfeng Cliff 
Published: October 2017

Abstract
RNA folds into intricate structures that are crucial for its functions and regulations. To date, a multitude of approaches for probing structures of the whole transcriptome, i.e., RNA structuromes, have been developed. Applications of these approaches to different cell lines and tissues have generated a rich resource for the study of RNA structure–function relationships at a systems biology level. In this review, we first introduce the designs of these methods and their applications to study different RNA structuromes. We emphasize their technological differences especially their unique advantages and caveats. We then summarize the structural insights in RNA functions and regulations obtained from the studies of RNA structuromes. And finally, we propose potential directions for future improvements and studies.
Marshall bundle reentrant atrial tachycardia after the Cox‐Maze IV procedure: The last barrier of the conduction pathway between the coronary sinus and left atrium
Authors: Wakabayashi Yasushi , Hayashi Takekuni , Sugawara Yoshitaka , Mitsuhashi Takeshi , Fujita Hideo , Momomura Shin‐ichi 
Published: October 2017

AbstractA 74‐year‐old woman who developed atrial tachycardia following the Cox‐Maze IV procedure underwent catheter ablation. The reentrant circuit included the coronary sinus (CS), Marshall bundle (MB), distal MB‐left atrial (LA) connection, and anterolateral mitral annulus. The distal MB‐LA connection was the last barrier in the conduction pathway between the CS and the left atrium.
PAH mutation spectrum and correlation with PKU manifestation in north Jiangsu province population
Authors: Wang Zhen‐Wen , Jiang Shi‐Wen , Zhou Bao‐Cheng 
Published: October 2017

AbstractPhenylketonuria (PKU) is a common autosomal recessive disorder of phenylalanine metabolism and mainly results a deficiency of phenylalanine hydroxylase gene (PAH). The incidence of various PAH mutations have race and ethnicity differences. We report a spectrum of PAH mutations complied from 35 PKU children who are all Chinese Han population from north Jiangsu in this study. All 13 exons and their flanking intron sequences of PAH were determined by Ion Torrent PGM™ sequencing. The relationship of genotype and phenotype was analyzed based on the sum of the arbitrary value (AV) values of the two alleles. We identified 61 mutations, with a frequency of 87.14%, among 70 alleles of 35 patients. The most prevalent mutations were R243Q (26.23%), R241C (9.84%) and V399V (8.20%). Furthermore, the consistency between prediction of the biochemical phenotype and the observed phenotype was 81.25%, with the highest consistency observed in classic PKU (87.50%). A significant correlation was found between pretreatment levels of phenylalanine and AV sum (r = −0.87, P < 0.05). Finally, our study constructs PAH mutation spectrum by next generation sequencing (NGS), and reveals that the PAH genotypes and biochemical phenotypes were significantly correlated. These offers facilitate the provision of appropriate genetic counseling for PKU patients.
A novel miniature, wireless neurostimulator in the management of chronic craniofacial pain: Preliminary results from a prospective pilot study
Authors: Weiner Richard L. , Garcia Carlos Montes , Vanquathem Niek 
Published: October 2017

Abstract

Objective
To report a novel wireless neuromodulation system for treatment of refractory craniofacial pain.

Background
Previous studies utilizing peripheral nerve stimulation (PNS) of the occipital and trigeminal nerves reported positive outcomes for alleviating neuropathic pain localized to the craniofacial and occipital areas. However several technological limitations and cosmetic concerns inhibited a more widespread acceptance and use of neuromodulation. Also, a relatively high incidence of adverse events like electrode erosions, dislocation, wire fracture and/or infection at the surgical site mandates a change in our approach to neuromodulation technology and implant techniques in the craniofacial region.

Methods
We report a novel approach for the management of craniofacial pain with a wirelessly powered, minimally invasive PNS system. The system is percutaneously implanted and placed subcutaneously adjacent to affected facial nerves via visual guidance by the clinician. In this feasibility study, pilot evidence was gathered in a cohort of ten subjects suffering from a combination of chronic headaches, facial pain for at least 15 days per month and for at least 4 h/day.

Results
At four weeks post-implant follow up, all patients reported sustained pain relief of the primary pain area. Electrode location and total number of electrodes used per subject varied across the cohort. The average pain reduction using the visual analog scale was >82%. The procedure had no adverse events or side effects.

Conclusions
Percutaneous placement of a wireless neurostimulation device directly adjacent to affected craniofacial nerve (s) is a minimally invasive and reversible method of pain control in patients with craniofacial pain refractory to conventional medical managements. Preliminary results are encouraging and further larger scale studies are required for improved applications.
Abnormalities of tumor endothelial cells and cancer progression
Authors: Hida Kyoko , Maishi Nako 
Published: October 2017

AbstractTumor growth and metastasis are dependent on angiogenesis, which is the formation of new blood vessels. The newly formed blood vessels around the tumor supply oxygen and nutrients to the tumor, supporting its progression. Moreover, these blood vessels also serve as channels through which tumor cells metastasize to distant organs. The balance between angiogenic stimulators and inhibitors regulates angiogenesis in the tumor microenvironment. Tumor blood vessels, especially the endothelial cells lining tumor blood vessels (tumor endothelial cells [TECs]), are important targets in cancer therapy. As newly formed tumor blood vessels originate from pre‐existing normal vessels, tumor blood vessels and TECs have traditionally been considered to be the same as normal ones.However, tumor blood vessels have a distinctively abnormal phenotype, including morphological alterations. Recently, it has been revealed that TECs constitute a heterogeneous population, exhibiting characteristics that are largely induced by tumor microenvironmental factors. Furthermore, TECs induce cancer progression through metastasis. In this review, we describe recent studies on TEC abnormalities related to cancer progression and consider their therapeutic implications.
Semi-empirical estimation and experimental method for determining inertial properties of the Unmanned Aerial System – UAS-S4 of Hydra Technologies
Authors: Tondji Y. , Botez R. M. 
Published: October 2017

ABSTRACTThis article presents a structural analysis of the Unmanned Aerial System UAS-S4 ETHECATL. Mass, centre of gravity position and principal mass moment of inertia are numerically determined and further experimentally verified using the ‘pendulum method’. The numerical estimations are computed through Raymer and DATCOM statistical-empirical methods coupled with mechanical calculations. The mass of the UAS-S4 parts are estimated according to their sizes and the UAS-S4 class, by the means of Raymer statistical equations. The UAS-S4 is also decomposed in several simple geometrical figures which centres of gravity are individually computed, weighted and then arithmetically averaged to find the whole UAS-S4 centre of gravity. In the same way, DATCOM equations allows us to estimate the mass moments of inertia of each UAS-S4 parts that are finally sum up according to the Huygens-Steiner theorem for computing the principal moment of inertia of the whole UAS-S4. The mass of de UAS-S4 is experimentally determined with two scales. Its centre of gravity coordinates and its mass moment of inertia are found using the pendulum method. A bifilar torsion-type pendulum methodology is used for the vertical axis(14)and a simple pendulum methodology is used for the longitudinal and transversal axes(12). The test object is installed on a pendulum (simple or bifilar torsion pendulum) which is led to oscillate freely while recording the oscillation's angles and speed, by the means of three sensors (an accelerometer, a gyroscope and a magnetometer) that the calibration is also discussed. Simultaneously, nonlinear dynamic models are developed for the rotational motion of pendulums, including the effects of large-angle oscillations, aerodynamic drag, viscous damping and additional momentum of air. ‘Algorithms of minimization’ are then used to simulate and actualise the dynamic models and finally chose the model that simulated data best fit the experimentally recorded one. Pendulum parameters, such as mass moment of inertia, are lastly extracted from the chosen model. To determine the accuracy of the nonlinear dynamics approach of the pendulum method, the experimental results for an object of uniform density for which the mass moments of inertia are computed numerically from geometrical data are presented along with the experimental results obtained for the UAS-S4 ETHECATL. For the uniform density object, the experimental method gives, with respect to the numerical results, an error of 4.4% for the mass moment of inertia around theZaxis and 9.5% for the moment of inertia around theXandYaxes. In addition, the experimental results for the UAS-S4 inertial values validate the numerical calculation through DATCOM method with a relative error of 6.52% on average.
Power in international trade politics: is ISDS a solution in search of a problem?
Authors: Reddie Andrew 
Published: October 2017

AbstractThis article examines the controversial investor-state dispute settlement (ISDS) mechanisms in recent mega-free trade agreement. Below, I examine the origins of the ISDS concept and outline the controversy surrounding its use in the context of the Transatlantic Trade and Investment Partnership (TTIP). Then, I provide a theoretical discussion that outlines both the exogenous and endogenous factors that contribute to the inclusion of ISDS provisions in international trade agreements. Focusing on the latter endogenous factors, I then argue that not all international trade agreements are the same and that, as such, it is possible to develop a typology of international trade agreement across two variables (the number of parties and relative power) that impact the appropriateness of including an ISDS provision. I test this typology against the empirical record. Finally, I discuss potential innovations to the ISDS provisions and market-based mechanisms that address the dual challenges of discrimination and expropriation that ISDS is designed to address.1
Emerging age asymmetries in the research relationship: challenges of exploring transition to the fourth age
Authors: SEDLÁKOVÁ TATIANA , SOURALOVÁ ADÉLA 
Published: October 2017

ABSTRACTThis article opens the discussion on age asymmetries within the research relationship between researchers who are young and able-bodied and research participants who are much older and have acquired impairments in later life. Based on the knowledge of age relations, we present our conceptualisation of power imbalances based on age. We see these asymmetries as co-existing with other forms of power imbalances between researchers and participants, and argue that these asymmetries are not the results of the limitations of the older adults but rather the consequences of different constellations of possibilities for researchers and participants. Moreover, we assert that taking these asymmetries into account is a necessary step when conducting research with people with acquired impairment in later life. As researchers, reflecting on age asymmetries helped us to avoid othering our research participants and prevented us from marginalising their life experiences. Drawing upon our own research, we reflect upon the network of cognitive, physical and social asymmetries that emerged in our research relationships and identify the main challenges that we faced. In the presence of some of these age asymmetries, we approach the research relationship through the roles which we played vis-à-vis the participants. We consider reflecting and addressing these asymmetries to be a necessary step in creating and maintaining a research relationship based on equality. Only a reflexive and transparent approach to these power imbalances can ensure that data collection and analysis do not contribute to their reproduction. This article presents some general insights on research practices and contributes to the debate on power imbalances in qualitative research. The article also contributes to gerontology and provides new insights about the lives of those individuals with acquired impairment in later life, a topic that has so far received inadequate research attention.
Education and Successful Aging Trajectories: A Longitudinal Population-Based Latent Variable Modelling Analysis
Authors: Cosco Theodore D. , Stephan Blossom C.M. , Brayne Carol , Muniz Graciela ,   MRC CFAS
Published: October 2017

ABSTRACTAs the population ages, interest is increasing in studying aging well. However, more refined means of examining predictors of biopsychosocial conceptualizations of successful aging (SA) are required. Existing evidence of the relationship between early-life education and later-life SA is unclear. The Successful Aging Index (SAI) was mapped onto the Cognitive Function and Aging Study (CFAS), a longitudinal population-based cohort (n = 1,141). SAI scores were examined using growth mixture modelling (GMM) to identify SA trajectories. Unadjusted and adjusted (age, sex, occupational status) ordinal logistic regressions were conducted to examine the association between trajectory membership and education level. GMM identified a three-class model, capturing high, moderate, and low functioning trajectories. Adjusted ordinal logistic regression models indicated that individuals in higher SAI classes were significantly more likely to have higher educational attainment than individuals in the lower SAI classes. These results provide evidence of a life course link between education and SA.
The Flying Dutchman, English Spectacle and the Remediation of Grand Opera
Authors: Cruz Gabriela 
Published: October 2017

AbstractRichard Wagner wrote in 1852 that in settling on the theme of the phantom ship he had entered ‘upon a new path, that of Revolution against our modern Public Art’, that is,grand opéra. Wagner’s revolution has often been described in light of the poetics of return and homecoming that contributed a new sense of identity to (German) opera. The present article is written against the grain of this conviction, and highlights the cosmopolitan career of the phantom ship and of the vernacular art forms – the nautical theatre and the phantasmagoria – that maintained the seafaring image at the forefront of the liberal imagination, first in Britain, and then in Paris, where Wagner arguably seized on it. Specifically, it explores the significance of ‘apparitional images’ to mid-nineteenth-century opera and Wagner’s turn to a regime of modern spectacle, inspired by the art of phantasmagoria, inDer fliegende Holländer.
Challenges for bilateral pulmonary artery stenting due to occluded femoral veins
Authors: Pavithran Sreeja , Chandrasekaran Ramyashri , Sivakumar Kothandam 
Published: October 2017

AbstractWhen the inferior caval vein is occluded or abnormal, jugular and hepatic veins provide alternative routes for interventions. For pulmonary artery stenting, transhepatic access may give a relatively straighter route than that from the jugular veins. We describe the challenges and strategies during transhepatic bilateral pulmonary artery stenting after arterial switch operation complicated by occluded inferior caval vein and congested hepatic veins.
Pre-gestational excessive weight and duration of breast-feeding
Authors: Sotero Andréa M , Ferreira Haroldo da S , Assunção Monica L , de Lira Pedro Israel C 
Published: October 2017

AbstractObjectiveTo investigate whether pre-gestational obesity interferes with the duration of breast-feeding.DesignA cross-sectional study was carried out with a population-based probabilistic sample. The dependent variables were exclusive breast-feeding (EBF) and breast-feeding (BF), as defined by the WHO. The classification of pre-gestational nutritional status was based on the pre-gestational BMI category.SubjectsA sample of 418 mother–infant pairs from the state of Alagoas, Brazil.ResultsThe median duration of EBF was 1·9 months (60d), while that of BF was 8·2 months (250d). According to multiple linear regression analysis, the factors that negatively and independently affected the duration of EBF were pre-gestational BMI≥30·0 kg/m2 (−51·9d, 95 % CI −80·4, −23·4), maternal schooling≤9 years (−30·8d, 95 % CI −54·7, −6·9), no prior lactation experience (−29·0d, 95 % CI −45·6, −11·5) and infant pacifier use (−41·4d; 95 % CI 54·5, −28·2). For BF, a higher weaning rate was observed during the first days after birth among children of pre-gestational obese mothers.ConclusionsThe results suggest that higher pre-gestational BMI is associated with shorter duration of EBF and BF. Prenatal care provides a privileged opportunity to promote nutritional education, better nutritional status of pregnant woman, and greater success with EBF up to 6 months of age and with longer BF.
Random generation of closed simply typed λ-terms: A synergy between logic programming and Boltzmann samplers
Authors: BENDKOWSKI MACIEJ , GRYGIEL KATARZYNA , TARAU PAUL 
Published: October 2017

AbstractA natural approach to software quality assurance consists in writing unit tests securing programmer-declared code invariants. Throughout the literature, a great body of work has been devoted to tools and techniques automating this labour-intensive process. A prominent example is the successful use of randomness, in particular, random typable λ-terms, in testing functional programming compilers such as the Glasgow Haskell Compiler. Unfortunately, due to the intrinsically difficult combinatorial structure of typable λ-terms, no effective uniform sampling method is known, setting it as a fundamental open problem in the random software testing approach. In this paper, we combine the framework of Boltzmann samplers, a powerful technique of random combinatorial structure generation, with today's Prolog systems offering a synergy between logic variables, unification with occurs check and efficient backtracking. This allows us to develop a novel sampling mechanism able to construct uniformly random closed simply typed λ-terms of up size 120. We apply our techniques to the generation of uniformly random closed simply typed normal forms and design a parallel execution mechanism pushing forward the achievable term size to 140.
Spontaneous disorder: conflict-kindling institutions in virtual worlds
Authors: MILDENBERGER CARL DAVID 
Published: October 2017

AbstractThis paper analyses the emergence and persistence of disorder due to bellicose (i.e. ‘conflict-kindling’) institutions. It does so relying on a novel empirical approach, examining the predatory and productive interactions of 400,000 users of a virtual world as well as its institutions. The paper finds that while there are many cases of spontaneous order in that virtual world, and while the users are not more conflict-loving as such, bellicose institutions sanctioning suicidal attacks in a supposedly safe region spontaneously emerged and rigidly persist, thus upholding disorder (i.e. a particularly violent kind of ordered anarchy).
Ethnoreligious Identity, Immigration, and Redistribution
Authors: Soroka Stuart , Wright Matthew , Johnston Richard , Citrin Jack , Banting Keith , Kymlicka Will 
Published: October 2017

AbstractDo increasing, and increasingly diverse, immigration flows lead to declining support for redistributive policy? This concern is pervasive in the literatures on immigration, multiculturalism and redistribution, and in public debate as well. The literature is nevertheless unable to disentangle the degree to which welfare chauvinism is related to (a) immigrant status or (b) ethnic difference. This paper reports on results from a web-based experiment designed to shed light on this issue. Representative samples from the United States, Quebec, and the “Rest-of-Canada” responded to a vignette in which a hypothetical social assistance recipient was presented as some combination of immigrant or not, and Caucasian or not. Results from the randomized manipulation suggest that while ethnic difference matters to welfare attitudes, in these countries it is immigrant status that matters most. These findings are discussed in light of the politics of diversity and recognition, and the capacity of national policies to address inequalities.