bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estrogen–Estrogen Receptor α Signaling Facilitates Bilirubin Metabolism in Regenerating Liver Through Regulating Cytochrome P450 2A6 Expression
Authors: Kao Ta-Lun , Chen Yao-Li , Kuan Yu-Ping , Chang Wei-Chun , Ho Yu-Chen , Yeh Shuyuan , Jeng Long-Bin , Ma Wen-Lung 
Published: January 2018

Background: After living donor liver transplantation (LDLT), rising serum bilirubin levels commonly indicate insufficient numbers of hepatocytes are available to metabolize bilirubin into biliverdin. Recovery of bilirubin levels is an important marker of hepatocyte repopulation after LDLT. Cytochrome P450 (CYP) 2A6 in humans (or cyp2a4 in rodents) can function as “bilirubin oxidase.” Functional hepatocytes contain abundant CYP2A6, which is considered a marker for hepatocyte function recovery. The aim of our study was to determine the impact of estradiol/estrogen receptor signaling on bilirubin levels during liver function recovery. Methods: We conducted a hospital-based cohort study of bilirubin levels after LDLT surgery in both liver graft donors and recipients, performed a transcriptome comparison of wild-type versus estrogen receptor (ER)α knockout mice and a bioinformatics analysis of transcriptome changes in their regenerating liver after two-third partial hepatectomy (PHx), and assayed in vitro expression of cytochrome (CYP2A6) in human hepatic progenitor cells (HepRG) treated with 17β-estradiol (E2). Results: The latency of bilirubin level reduction was shorter in women than in men, suggesting that a female factor promotes bilirubin recovery after liver transplantation surgery. In the PHx mouse model, the expression of the cyp2a4 gene was significantly lower in livers from the knockout ERα mice than in livers from their wild-type littermates; but the expression of other bilirubin metabolism–related genes were similar between these groups. Moreover, E2 or bilirubin treatments significantly promoted CYP2A6 expression in hepatocyte progenitor cells (HepRG cells). Sequence analysis revealed similar levels of aryl hydrocarbon receptor (AhR; bilirubin responsive nuclear receptor) and ESR1 binding to the promoter region of CYP2A6. Conclusions: This is the first report to demonstrate, on a molecular level, that E2/ERα signaling facilitates bilirubin metabolism in regenerating liver. Our findings contribute new knowledge to our understanding of why the latency of improved bilirubin metabolism and thereby liver function recovery is shorter in females than in males.
An analysis of emergency tracheal intubations in critically ill patients by critical care trainees
Authors: Arulkumaran Nishkantha , McLaren Charles S , Arulkumaran Kailash , Philips Barbara J , Cecconi Maurizio 
Published: January 2018

Introduction We evaluated intensive care medicine trainees’ practice of emergency intubations in the United Kingdom. Methods Retrospective analysis of 881 in-hospital emergency intubations over a three-year period using an online trainee logbook. Results Emergency intubations out-of-hours were less frequent than in-hours, both on weekdays and weekends. Complications occurred in 9% of cases, with no association with time of day/day of week (p = 0.860). Complications were associated with higher Cormack and Lehane grades (p=0.004) and number of intubation attempts (p < 0.001), but not American Society of Anesthesiologist grade. Capnography usage was ≥99% in all locations except in wards (85%; p = 0.001). Ward patients were the oldest (p < 0.001), had higher American Society of Anesthesiologist grades (p < 0.001) and lowest Glasgow Coma Scale (p < 0.001). Conclusions Complications of intubations are associated with higher Cormack and Lehane grades and number of attempts, but not time of day/day of week. The uptake of capnography is reassuring, although there is scope for improvement on the ward.
Venous Thromboembolism in Podiatric Foot and Ankle Surgery
Authors: Matthews Jemma H. , Terrill Alexander J. , Barwick Alex L. , Butterworth Paul A. 
Published: January 2018

Background: The extent to which podiatric surgeons follow venous thromboembolism guidelines is unknown. The aim of this study therefore, was 2-fold: (a) to determine the rate of venous thromboembolism following podiatric surgery and (b) to investigate the factors that influence the use of thromboprophylaxis. Methods: Data from 4238 patients who underwent foot and ankle surgery over 2 years were analyzed. Venous thromboembolism within the first 30 days following surgery was recorded using the Australasian College of Podiatric Surgeons surgical audit tool. Logistic regression analyses were undertaken to determine the factors that influenced thromboprophylaxis. Results: Of the 4238 patient records, 3677 records (87%) provided complete data (age range 2-94 years; mean ± SD, 49.1 ± 19.7 years; 2693 females). A total of 7 venous thromboembolic events (0.2% rate) were reported. Operative duration and age (OR 12.63, 95% CI 9.47 to 16.84, P < 0.01), postoperative immobilization (OR 6.94, 95% CI 3.95 to 12.20, P < 0.01), and a prior history of VTE (OR 3.41, 95% CI 1.01 to 11.04, P = 0.04) were the strongest predictors of thromboprophylaxis. Conclusion: Podiatric foot and ankle surgery is associated with a low rate of venous thromboembolism. This may be due in part to the thromboprophylaxis regime implemented by podiatric surgeons, which closely aligns with current evidence-based guidelines. Levels of Evidence: Level II: Prospective cohort study
Quantitative proteomics of plasma vesicles identify novel biomarkers for hemoglobin E/β-thalassemic patients
Authors: Kittivorapart Janejira , Crew Vanja Karamatic , Wilson Marieangela C. , Heesom Kate J. , Siritanaratkul Noppadol , Toye Ashley M. 
Published: January 2018

Key PointsChaperones, antioxidants, iron-sequestering proteins, and cathepsin S exhibited increased abundance in thalassemic EVs. Haptoglobin and hemopexin are reduced in thalassemic patients’ EVs, reflecting hemolysis. These could be used as clinical biomarkers.
Immune-Modified Response Evaluation Criteria In Solid Tumors (imRECIST): Refining Guidelines to Assess the Clinical Benefit of Cancer Immunotherapy
Authors: Hodi F. Stephen , Ballinger Marcus , Lyons Benjamin , Soria Jean-Charles , Nishino Mizuki , Tabernero Josep , Powles Thomas , Smith David , Hoos Axel , McKenna Chris , Beyer Ulrich , Rhee Ina , Fine Gregg , Winslow Nathan , Chen Daniel S. , Wolchok Jedd D. 
Published: January 2018

Purpose Treating solid tumors with cancer immunotherapy (CIT) can result in unconventional responses and overall survival (OS) benefits that are not adequately captured by Response Evaluation Criteria In Solid Tumors (RECIST) v1.1. We describe immune-modified RECIST (imRECIST) criteria, designed to better capture CIT responses. Patients and Methods Atezolizumab data from clinical trials in non–small-cell lung cancer, metastatic urothelial carcinoma, renal cell carcinoma, and melanoma were evaluated. Modifications to imRECIST versus RECIST v1.1 included allowance for best overall response after progressive disease (PD) and changes in PD definitions per new lesions (NLs) and nontarget lesions. imRECIST progression-free survival (PFS) did not count initial PD as an event if the subsequent scan showed disease control. OS was evaluated using conditional landmarks in patients whose PFS differed by imRECIST versus RECIST v1.1. Results The best overall response was 1% to 2% greater, the disease control rate was 8% to 13% greater, and the median PFS was 0.5 to 1.5 months longer per imRECIST versus RECIST v1.1. Extension of imRECIST PFS versus RECIST v1.1 PFS was associated with longer or similar OS. Patterns of progression analysis revealed that patients who developed NLs without target lesion (TL) progression had a similar or shorter OS compared with patients with RECIST v1.1 TL progression. Patients infrequently experienced a spike pattern (TLs increase, then decrease) but had longer OS than patients without TL reversion. Conclusion Evaluation of PFS and patterns of response and progression revealed that allowance for TL reversion from PD per imRECIST may better identify patients with OS benefit. Progression defined by the isolated appearance of NLs, however, is not associated with longer OS. These results may inform additional modifications to radiographic criteria (including imRECIST) to better reflect efficacy with CIT agents.
Agama: Sebuah Upaya Pembebasan Manusia (Perspektif-Dialogis Islam dan Kristen)
Authors: Muin Munawir 
Published: January 2018

Contemporary issues are present in the course of human civilization. In this part, religion should take its participation and offer a solution to these human contemporary issues. Religion should play an immense role solving the existing conflicts, but not serve as the source of conflicts. It is significant, in this context, to underscore religion as a solution of liberating human from their conflicts. The populist type of religiosity is demanding. It does not refer to place religiosity in its plain aim, but serves it as a medium pursuing the welfare of life. It leads to pluralist-liberalist traits that aware the truth outside one’s religion, support respects and tolerance to others in terms of their religious expressions.
Membongkar Patriarkhisme Islam sebagai Kearifan Budaya Lokal: Sebuah Kritik Terhadap UU. No. 1 Tahun 1974 Tentang Perkawinan
Authors: Asnawi Habib Shulton 
Published: January 2018

Patriarchism’s Islam is not a form of accusation that Islam is a patriarchal religion. Patriarchism’s Islam here is a way of interpretation by certain circles, because of its cultural, political, social and historical role of specific, resulting in the claim that Islam is a religion that favor the ideology of patriarchy. This patriarchal ideology that considers women as inferior beings position than men. This forms a negative paradigm to the framers of the law in particular is the law. No. 1 Year 1974 About Marriage. As a result of the UUP, women in Indonesia, suffered discrimination and injustice, this is certainly a violation of human rights. The protection of women's rights is the duty of the government of Indonesia. Therefore, reform/amendment UUP is a necessity that should be done, in order of justice, equality and protection of human rights, especially as indigenous efforts in Indonesia.
Islam dan Kearifan Budaya Lokal: Studi Terhadap Tradisi Penghormatan Arwah Leluhur Masyarakat Jawa
Authors: MS Erwin Arsadani 
Published: January 2018

Islam and Java for Indonesia are like two wings of a bird. It’s like opposite each other impressed even hostile. Even been divided into two, namely students and Javanese, is unlikely to meet and continue bersebrangan. But as the two wings flapping both need each other. This is because the majority of the people of Java and Indonesia is the largest religion in the country is Islam. So the majority of people in Indonesia are Muslim Javanese. Because it would be synonymous with Muslim Javanese. Javanese people like pilgrimage, honoring the ancestors, leaders and powerful people. Java has cultural roots of respect for ancestors had to deal with Islamic monotheism. Early days of the Islamic clerics in Indonesia have discovered a way to bring together some of the culture of Java with the teachings of Islam. But there are still many Javanese culture which according to Islam is not in accordance with the principle of tawhid. It is certainly necessary theological evaluation of the scholars teaching Muslims that Islam is really rooted.
Keberagamaan Koruptor Menurut Psikologi (Tinjauan Orientasi Keagamaan dan Psikografi Agama)
Authors: Ismail Roni 
Published: January 2018

All of religion forbids all followers to do something that could harm others. Any religion has principles that must be complied with by all adherents, either ban or printah. One of the ban as "stealing money" corruption. This Coruption is certainly very forbidden by any religion, because Coruption not only harms the individual and the group, but much more dangerous is the people. Many of the perpetrators of corrupt framing comply with such personality that embraced religion. Is it true that someone who actually obey the religion he embraced still violate religious rules? Aartikel will analyze religious corruption from the perspective of psychology of religion that would be obtained by using the empirical explanation of the two theories in the psychology of religion, namely: Religious Orientation and Religion or psychographic dimensions Religiosity. Evident in a corrupt personality split (split personality) as opposed to monotheism. People who have split personality is not one word and deed, while the tauhid one word and deedwhat is believed, it is said, thought the same as what it does.
Masa Depan Kehidupan Beragama dan Kearifan Budaya Lokal: Studi terhadap Pemikiran Abdurrahman Wahid Mengenai Asal Usul Peradaban Islam dan Implikasinya Di Masa Mendatang
Authors: Shofiyyuddin M. 
Published: January 2018

This article elaborates abdurrahman wahid’s concept about the origin of islamic civilization. Islam humanist, in the view of gusdur, is the view of history that describes so close to reality in past. History that is not to see the past in mythic and humanity. Someone’s view of the past as it is, is going to determine one’s outlook on the future. Respect and careful consideration based on factual condition of socity is formed by knowledge and concept about the history around him. Finally, Islam humanist is Islam that remarkes human rights, fair and equal before the law, defending minority, and also toleration to the local wisdom or native ways of religion.
Dualisme Agama: Menilik Peranannya atas Kedamaian dan Kesengsaraan
Authors: Widagdo Haidi Hajar 
Published: January 2018

Agama memainkan peran penting dalam kehidupan manusia, sebagai sesuatu yang memiliki fungsi pengatur kehidupan manusia, agama seharusnya membawa kepada perdamaian serta kasih sayang, namun dalam kenyataan seringkali agama berubah fungsi. Layaknya dua sisi mata uang. Agama yang awalnya menjadi sumber kedamaian dan kebahagiaan, seringkali berubah menjadi sumber ketegangan, teror yang menakutkan. Vandalisme dan tindakan kekerasan lainnya sering kali beratasnamakan agama. Otoritas keagamaan disalahgunakan dan itu terjadi berulang-ulang, dan akhirnya kesucian agama itu ternodai. Pemaknaan nilai agama sebagai sebuah entitas yang membawa perdamaian harus disadari kembali, sehingga agama dapat kembali ke fungsi awalnya sebagai pusat kedamaian.[Religion plays an important role in human life, as something that has a regulatory function of human life, religion should lead to peace and love, but in reality often religious change function. Like the two sides of the coin. Religion is initially a source of peace and happiness, often turn out to be a source of tension, terror scary. Vandalism and other acts of violence often beratasnamakan religion. Religious authority abused and it happens over and over again, and finally the sanctity of religion was tainted. Meaning of religious values as an entity that brings peace have to realize again. Thus, religion can be returned to the original function as a center of peace.]
Ayat-ayat Perdamaian: Dekonstruksi Tafsir ala Jane Dammen McAuliffe
Authors: Lukman Fadhli 
Published: January 2018

Its is the matter of fact that Muslims way to behave, including to behave before other communities, such as Christians, comes from the Qur’an. To understand how Muslims do something on their religiousity is then to come analyzing the Qur’an. This is what Jane Dammen McAulife fully aware of; She is curious of how the Qur’an presents the Christians. However, since the Qur’an further controlled by exegesis, it become an integral aspect in her way to study Qura’nic Christians. This paper will descriptively explore Jane Dammen McAuliffe’s though on Qur’anic presentation to Christians. Her dissertation will be the basis of analysis. However, we previously present the mapping of her whole thought to gain the comprehensive understanding on her complete thought. In context of Qur’anic Christians, she concludes that since the exegesis controls the Qur’an, Qur’anic Christians refer to nor historical Christians nor the living community call themselves as Christians.
“Merariq Syar’i” di Lombok: Studi Living Hadis di Dusun Lendang Simbe
Authors: Salimudin Salimudin 
Published: January 2018

This study discusses one of the topics in Living Hadits found in Merariq (Marriage) tradition in Dusun Lendang Simbe. The case indicates the instance of various interpretations and Muslim society’s receptive mode of Hadits. In this vein, Hadits has not been only served as books and readings; it could be managed as ‘driving force’ in a broader understanding and tolerance. It seems that the Sasak Muslim could mingle the positionality of Islam in the face of cultural aspect. The study shows that Muslims lived in Lendang Simbe following the command of ‘Tuan Guru’ to avoid the tradition of ‘bebait’ (kidnapping). In the case of ‘nyongkolan’ tradition, they still preserved it with a little modification on the outfits without diminishing the Sasak’s value and meaning.
“Kesarjanaan Revisionis” dalam Studi Al-Qur’an (Upaya Merekonstruksi Sumber Awal Kemunculan Teks al-Qur’an)
Authors: Muzayyin Muzayyin 
Published: January 2018

The challenge on the Qur’anic studies will never be end. For many centuries, The Qur’an always attracted many people attention all over the world, to treat or to examine the truth; whether the Qur’an as the word of God or the word of Muhammad ?. This is therefore, starting from that point, This paper particularly will attempt to explores a new trend of Qur’anic studies by the emerging of Revisionist Western scholarship theories of Islamic origins. In their analysis shown that the documentary sources or the beginnings of historical writing in the Islamic tradition must be considered in controversies. One might argues that the Qur’an contains several different kinds of material, hypothesizes that different parts of the Qur’an originated in different communities, some or all of which, were located not in Arabia, but in Iraq or Syria. Moreover, the analysis come to the conclusion that the Qur’anic text as we now know coalesced only slowly and does not assume final form until the late second/eighth century or even later. Taking the notion that the traditions about Islamic origins are the products of long and partly oral evolution. The aim of this paper then will describe the fact on how the revisionist western scholarship try to reconfigurate the reliable information about Islamic origin.[Tantangan studi al-Qur’an tidak akan pernah berakhir. Selama berabad-abad lamanya, al-Qur’an selalu menjadi perhatian banyak orang di seluruh penjuru dunia. Guna menguji kebenaran, yakni apakah ia benar-benar firman Tuhan atau kah perkataan Muhammad ? oleh karena itu, berangkat dari point ini, tulisan ini secara spesifik akan mengeksplorasi tren terkini tentang studi al-Qur’an dengan memunculkan teori kemunculan Islam oleh kesarjanaan Barat Revisionis. Dalam analisis mereka menunjukkan bahwa sumber documenter atau sejarah awal penulisan al-Qur’an mengalami kontroversi. Ada yang beranggapan bahwa al- Qur’an berisi beberapa macam perbedaan materi atau redaksi, sebagian dari itu berasal dari perbedaan komunitas. Sebagian lainnya berargumen bahwa al-Qur’an turun bukan di jazirah Arab, melainkan di Iraq dan Syria. analisis sampai pada kesimpulan bahwa teks Al-Qur’an seperti yang kita tahu sekarang perlahan-lahan mengalami bentuk fibalnya kecuali pada akhir abad kedua/kedelapan atau bahkan kemudian. Atas dasar itu, kemunculan Islam (al-Qur’an) adalah produk evolusi yang berasal dari manusia jauh belakangan. Singkatnya, Tulisan ini akan mendeskripsikan realitas tentang bagaimana kesarjanaan Revisionis mencoba menata ulang data yang tersedia tentang kemunculan Islsam (al-Qur’an).]
BERFIKIR PROFETIK DALAM PEMBELAJARAN MATEMATIKA SD/MI
Authors: Muhammad Azamul Fadhly Noor 
Published: January 2018

Abstract
In the world of education, students who have a high learning interest can experience a decrease in interest in learning. One example in mathematics learning. If they are taught by the teacher in a tedious and cheery way, then the students will get bored quickly in accepting the learning in class. Preferably, students who have low motivation, can experience increased interest in learning if guided by a teacher who knows how to communicate and think well to the students. Prophetic thinking is thinking according to what the prophet teaches or does. Education with prophetic perspective means studying education as a great nation program that has a predictive power to a more brilliant future conducted by someone called a prophet who is an early speech or pioneer who proclaims himself and speaks the future. in teaching Mathematics lesson which is a lesson that is needed by the students as their provision to live life in society later. Not to mention the paradaban of our nation at this time so badly, so we seem to have lost identity as a dignified nation, so it is necessary to return the level of thinking as taught by the Nabi Muhammad SAW that we often call Profetic thinking, which actually was already taught by parents each before entering elementary school.
Keywords: Profetical Thinking, Learning, Elementary Mathematics.
PENERAPAN MODEL KOOPERTAIF TIPE SIMULTANEOUS ROUNDTABLE UNTUK MENINGKATKAN KETERAMPILAN SOSIAL SISWA
Authors: Sriwulan Agus 
Published: January 2018

This study aims to describe the implementation of Simultaneous RoundTable model of cooperative model to improve students' social skills in Tunjungsekar 5 Elementary School Malang. This type of research is a Classroom Action Research consist of 2 cycles. Each cycle consists of four stages, planning, implementation, observation, and reflection. The subjects of this research are 25 students in II B class of Tunjungsekar 5 Elementary School Malang year 2015/2016. Data on students' social skills are collected through observation sheets and interviews. The collected data then analyzed by using qualitative descriptive analysis technique. In the first cycle, the percentage of social skills of students by 55% and experienced a significant increase in cycle II of 87%. Based on the results of this study, students 'social skills are enhanced through the application of Simultaneous RoundTable model of cooperation which includes sub aspect (1) the ability to communicate with other students, (2) make friendship with peers, (3) listen to friends' opinions, (4) giving and receiving criticism from others, and (5) giving or receiving feedback.
Keywords: Simultaneous RoundTable type of Cooperative model, Students’ social skills
ANALISIS KEMAMPUAN LITERASI SAINS DI KELAS VC SD MUHAMMADIYAH CONDONGCATUR SLEMAN YOGYAKARTA
Authors: Yuliawati Fitri 
Published: January 2018

This study aims to determine how high the ability of science literacy learners in class VC SD Muhammadiyah Condongcatur Sleman Yogyakarta Year 2016-2017.This research uses non experimental quantitative approach with descriptive method. Technique of collecting data using test instrument in the form of multiple choice that has been validated the contents and constructs by experts and empirical validation using IBM SPSS Statistic 22 program with bivariate correlation analysis and using Product Moment Correlation formula. The population is the students of class V and the sample VC class students with sampling technique Simple Random Sampling at SD Muhammadiyah Condongcatur Sleman Yogyakarta. Data analysis is done by descriptive statistics.
The results can be concluded that the ability of science literacy learners in class VC SD Muhammadiyah Condongcatur Sleman Yogyakarta academic year 2016-2017 is divided into 5 criteria. Very high criteria there are 7 students with 19.44%, high criteria there are 5 students with 13.88%, medium criteria there are 16 students with 44.44%, low criteria there are 3 students with 8,33% and very low criteria there are 5 students with 13.88%.
Keywords: PISA, Literacy Science ability, SD Muhammadiyah Condongcatur