bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study on existence of wormhole in Lemaitre–Tolman–Bondi model
Authors: Chakraborty Subenoy , Chakraborty Madhukrishna 
Published: September 2024

AbstractAn investigation has been done for possible existence of evolving wormhole (WH) solution in the background of inhomogeneous Lemaitre–Tolman–Bondi (LTB) space-time geometry. Using separable product form of the geometric (or area) radius, the shape function can be evaluated in terms of the functional part of the radial coordinate in the area radius. The conditions for a viable WH configuration have been examined.
Structural Characteristics and Dielectric Properties of Deposited Silver Nanoparticles with Polypyrrole on PET Films for Dielectric Devices
Authors: Atta A. , Al-Harbi Nuha , Abdeltwab E. , Altuijri Reem , Abdelhamied M. M. , Uosif M. A. M. 
Published: September 2024

Herein, (PPy-Ag)/PET composites, consisting of silver nanoparticles (AgNPs) and polypyrrole (PPy) coated on PET, were fabricated by the polymerization process and then the films were characterized by SEM and XRD techniques. The addition of PPy-Ag on the dielectric properties of PET were determined. The XRD proved the successful synthesis of the (PPy-Ag)/PET samples. The SEM results demonstrate the effect of Ag modified the characteristics of the composite, which confirmed the interaction of (PPy-Ag)/PET. The dielectric properties of the films in frequency of 50 Hz to 5.6 MHz were measured. The density energy was enhanced from 9.1 × 10−5 for PET to 5480 × 10−5 J m−3 for (PPy-Ag)/PET. Moreover, the relaxation time

τ

r

decreased from 1.7 × 10−5 for PET to 2.8 × 109 sec for (PPy-Ag)/PET. The obtained data confirm the incorporation of PPy-Ag by PET. This research has led to the development of novel physico-chemical properties in flexible polymeric nanocomposite films, which could be used in high-performance energy storage devices.
Two Innovations in the Barlaam Romance Research
Authors: Khintibidze Elguja 
Published: September 2024

Abstract
The Greek manuscripts of Barlaam romance, pointing out in the Lemma that the story was brought to the Holy City by the honorable man, monk Ioann of the monastery of Saint Sabas, supported establishing the name of Saint John Damascene as the author of the romance. According to this research, the bearer of this story was Iovanne- Tornike, a monk of Athos and a former Byzantine general. The monk Ioann mentioned in the Lemma was not a monk of the Laura of the Holy Sabba the Sanctified, but of the Georgian monastery of Oshki, where Saint Father Sabba was the abbot. Theological texts were copied there under Iovanne-Tornike’s guidance finding their way to Athos through his efforts. Two redactions of the Barlaam are preserved in Georgian manuscripts: The Wisdom of Balahvar and The Life of the Blessed Iodasaph. The first one is the short and original redaction. It preserves the earlier Christian reworking of this Eastern story, making it significant in studying the Arabic editions of the Balavhar and Būḏāsf.
Association of Biomarkers with the Severity of Depression
Authors: Agnihotri Shruti , Daripelly Suresh , Cherla Shirley Keerthana , Jopaka Ajay Kumar , Molanguri Umashankar 
Published: September 2024

Background: The pathogenesis of depression remains elusive and uncertain. The literature suggests that low-grade systemic inflammation might contribute to the etiology of depression. Other markers that are studied are serum magnesium and serum cortisol. The association between these factors might help understand the etiology. Methods: This was a cross-sectional study conducted on a sample of 40 participants. Socio-demographic data was noted, and the Hamilton depression rating scale was applied to rate the severity of depression. Blood samples were drawn at 8 a.m. to record a complete blood picture (to derive the neutrophil–lymphocyte ratio (NLR)), C-reactive protein, serum magnesium, and serum cortisol. Results: In this study, conducted on a sample size of 40, inflammatory markers such as C-reactive protein (CRP: mg/dl) and NLR were significantly increased to 15.52 ± 13.10 and 6.46 ± 2.92, respectively, showing an underlying inflammatory pathology. Serum cortisol (µg/dl) was also raised to 22.30 ± 5.46, and there was a fall in serum magnesium. Also, it is noteworthy that all these markers were significantly associated with the severity of depression, as the Pearson correlation between the Hamilton depression rating scale-21 item (HAM-D-21) score and CRP, NLR, and serum cortisol was positive and statistically significant ( r = 0.55, p < .01; r = 0.51, p = .01; r = 0.46, p = .002). The Pearson correlation between the HAM-D score and serum magnesium was negative and statistically significant ( r = -0.82, p < .01) Conclusion: There is a state of systemic inflammation, hypercortisolemia, and hypomagnesemia in depressive disorders.
Self-help digital mental health intervention in improving burnout and mental health outcomes among healthcare workers: A narrative review
Authors: Aye Lwin M. , Tan Min M. , Schaefer Alexandre , Thurairajasingam Sivakumar , Geldsetzer Pascal , Soon Lay K. , Reininghaus Ulrich , Bärnighausen Till , Su Tin T. 
Published: September 2024

Background Healthcare workers face burnout from high job demands and prolonged working conditions. While mental health services are available, barriers to access persist. Evidence suggests digital platforms can enhance accessibility. However, there is a lack of systematic reviews on the effectiveness of digital mental health interventions (DMHIs) for healthcare professionals. This review aims to synthesize evidence on DMHIs’ effectiveness in reducing burnout, their acceptability by users, and implementation lessons learned. Method This Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA)-guided review included 12 RCTs on DMHIs for healthcare professionals, published before 31 May 2024. The primary focus was on burnout, with secondary outcomes related to mental health and occupation. Quality appraisal used Cochrane risk of bias tools. A narrative synthesis explored DMHIs’ effectiveness, acceptability, utilization, and implementation lessons. Results Significant improvements in mental health outcomes were observed in 10 out of 16 RCTs. Burnout and its constructs showed significant improvement in five RCTs. Studies that measured the acceptability of the interventions reported good acceptability. Factors such as attrition, intervention design and duration, cultural sensitivities, flexibility and ease of use, and support availability were identified as key implementation considerations. Conclusions Web-based DMHIs positively impact burnout, mental health, and occupational outcomes among healthcare professionals, as shown in most RCTs. Future research should enhance DMHIs’ effectiveness and acceptability by addressing identified factors. Increasing awareness of DMHIs’ benefits will foster acceptance and positive attitudes. Lessons indicate that improving user engagement and effectiveness requires a multifaceted approach.
Short-Term Results With Ozaki Valved Conduit—A Simple Solution for Patients Needing Right Ventricle to Pulmonary Artery Conduit in a Low-Resource Setting
Authors: Raju Vijayakumar , Baird Christopher W. , Srinivasan Naveen , Sasikumar Divya Kadavanoor , Moorthy Rajalakshmi , Jothinath Koushik , Gangadharan Sreja , Swamy Kalyanasundaram Muthu , Raghavan Aparna Vijaya , Krishna Mani Ram , Nath Pavithra Ram 
Published: September 2024

Background The repair of certain types of complex congenital cardiac defects may require a right ventricle-pulmonary artery (RV-PA) conduit. Using the Ozaki Aortic valve neocuspidization (AVNeo)technique, a valved RV-PA conduit was constructed with an Ozaki valve inside a Dacron graft. This study aims to evaluate the short-term outcome of the Ozaki valved RV-PA conduit. Material/Method A total of 22 patients received the Ozaki valved RV-PA conduit from November 2019 until December 2023. The median age was 12 years (interquartile range [IQR], 5.5-21), median body weight was 35 kg (IQR, 15.8-48.5). The conduit was used in 16 patients (72.7%) under 18 years of age. Indications for conduit placement included: anatomic repair of corrected transposition of the great arteries, ventricular septal defect/pulmonary stenosis, conduit replacement, pulmonary atresia with associated anomalies, pulmonary artery aneurysm with dysplastic pulmonary valve, tetralogy of Fallot with coronary artery crossing the right ventricular outflow tract, bioprosthetic pulmonary valve regurgitation, and rheumatic heart disease. Native pericardium was used for the Ozaki valve in 12 patients and bovine pericardium for 10 patients. Conduit sizes ranged from 18 mm to 30 mm. Result The median intensive care unit stay was 4 (IQR, 2-6) days and the median hospital stay was 9 (IQR, 5.5-13.5) days. There were two perioperative mortalities (9.1%) both unrelated to the conduit. The median follow-up was 12.3 (IQR, 4.43-21.2) months. There was no infective endocarditis of the conduit. The median peak gradient across the conduit was 22 mm Hg (range 0-44 mm), and all were competent with trivial regurgitation on follow up. Conclusion Creation of an Ozaki valved conduit is an attractive option due to low cost, reproducibility, and excellent hemodynamics. Longer-term studies are needed to confirm the durability.
Knowledge, attitude and practices towards prevention and early detection of chronic kidney disease and associated factors in Ethiopia: A cross-sectional study
Authors: Gebreyohannes Lidiya Tekle , Wake Addisu Dabi , Abdulle Mohammed Usman 
Published: September 2024

Background: Early detection of chronic kidney disease (CKD) is important because it enables clinicians to initiate effective treatment, preventing loss of kidney function, and delaying or avoiding progression to kidney failure. This study was aimed to assess knowledge, attitude, and practices towards prevention and early detection of CKD and associated factors. Methods: Institution based cross-sectional survey was done at Adama Hospital Medical College, Ethiopia, between November 24/2021 and December 24/2021 among 190 hypertensive patients. Data were entered into EpiData version 4.2.0.0 and analyzed by Statistical Package for Social Sciences (SPSS) version 23. Result: The level of good knowledge, positive attitude, and good practice was 40.5%, 53.7%, and 47.4%, respectively. Government employed (AOR = 3.30, 95%CI: 1.38, 7.90), having an average monthly income of ≥3000 ETB (61.43 US dollars) (AOR = 2.95, 95%CI: 1.31, 6.66), and having a duration of ≥4 years since diagnosis of hypertension (AOR = 2.37, 95%CI: 1.11, 5.06) were factors significantly associated with good knowledge. Government employed (AOR = 2.56, 95%CI: 1.12, 5.87), having duration of hypertension ≥4 years since diagnosis (AOR = 2.16, 95%CI: 1.07, 4.36) were factors significantly associated with positive attitude. Government employed (AOR = 4.16, 95%CI: 1.38, 12.58), having an average monthly income of ≥3000 ETB (61.43 US dollars) (AOR = 6.74, 95%CI: 2.93, 15.52), having good knowledge towards prevention and early detection of CKD (AOR = 2.57, 95%CI: 1.14, 5.80) were significantly associated with good practice. Conclusions: The level of good knowledge, positive attitude, and good practice towards was low. Educational programs on these issues are required to minimize the burdens.
Morphea-like tattoo reaction in a patient with systemic sclerosis: Case report and review of the literature
Authors: Hobayan Catherine Grace P , Thai Jasmine , Korman Abraham M , Lin Judith 
Published: September 2024

Background: Morphea-like tattoo reactions are rare phenomena, with few cases reported in the literature. We present a case of a morphea-like tattoo reaction and a literature review of such reactions for comparison. Case Description: A 38-year-old woman with known history of systemic sclerosis presented with abnormal healing and skin thickening over a red tattoo. Histopathological examination revealed sclerosing dermatitis, consistent with morphea-like tattoo reaction. Treatment included topical clobetasol and oral mycophenolate mofetil. Methods: A literature search of PubMed and EMBASE was performed in August 2023 for known morphea-like tattoo reactions. No time or language filters were applied. Results: A total of six articles were included. Case reports of morphea-like tattoo reactions in patients with no significant past medical history comprise five articles. One review article notes that red tattoo ink with and without cinnabar is associated with adverse skin reactions. Conclusions: Morphea-like tattoo reactions can be triggered by ingredients of tattoo ink, possibly due to local hypersensitivity or the Koebner phenomenon. We encourage high clinical suspicion for morphea-like tattoo reactions when a patient with known history of connective tissue disease presents with skin changes around a tattoo.
Correlation of Doppler Indices Within the Umbilical Vein Compared With Gestational Age and Fetal Weight in a Normal Pregnancy
Authors: Jelany Saira , Farooq Syed Muhammad Yousaf , Rauf Fizza , Gilani Syed Amir , khawaja Abdullah Fazal , Jallad Lina Khaled 
Published: September 2024

Objective: Given the sophistication of ultrasonography, it is possible to explore and better comprehend the link between gestational age (GA), fetal weight (FW), and the diameter of the umbilical vein (UV). Therefore, the aim of this study was to determine whether a correlation exists between the Doppler indices, within the UV, compared with GA and FW, in a normal pregnancy. Materials and Methods: The design of this work was a cross-sectional analytical study. The sample size was calculated to include a sample size of 61, for statistical significance. A convenient sampling technique was used to collect the data. The inclusion criteria were to recruit pregnant women between the ages of 18 and 45 years, in the second and third trimester of pregnancy. In this cohort, the exclusion criteria were to be no co-existing maternal medical conditions chronic hypertension, gestational diabetes, cardiovascular problems, infections, hypercoagulability, and endocrine disorders. Results: A total of 61 pregnant women participated in this study, with a mean age of 25.21 ± 2.79 years. The mean GA was 32.4 ± 6.5 weeks. GA demonstrated a strong positive correlation with UV diameter ( r = .772, p < .001), UV velocity ( r = .687, p < .001), and UV volume ( r = .732, p < .001). UV diameter showed a strong positive correlation with UV velocity ( r = .593, p < .001) and an even stronger positive correlation with UV volume ( r = .928, p < .001). UV velocity showed a strong positive correlation with UV volume ( r = .754, p < .001). These findings may suggest that as GA increases, there are corresponding increases in UV diameter, velocity, and volume. Conclusion: In this cohort, the data collected demonstrated significant correlations between UV Doppler indices, GA, and FW, in normal pregnancies.
Surviving a classic heat stroke/hyperthermia > 42 °C – a case report
Authors: Schmidt Sonja Verena , Hinzmann Jannik , Stammler Anna , Wilhelms zu Bickern Paula , Macedo Santos Elisabete , Lehnhardt Marcus , Wallner Christoph 
Published: September 2024

Abstract
Introduction
Classic heat stroke is a severe trauma which can lead to multi-organ dysfunctions and is associated with a high mortality.

Case presentation
In this case report we present a 73-year-old patient with a classic heat stroke. His initial core body temperature was over 42 °C and he had a GCS of 3. Due to severe burn injuries the patient was transferred to a specialized burn center. The patient developed different organ failures and showed a prolonged course on the intensive care unit. Although the patient demonstrated different impaired organ systems, he recovered completely after receiving painstaking supportive therapy.

Conclusions
This is a rare case of a patient who fully recovered after a heat stroke with a temperature over 42 °C and severe sequelae.
Genomic diversity and population structure of Carniolan honey bee in its native habitat
Authors: Lukic Boris , Raguz Nikola , Kovačić Marin , Curik Ino , Obšteter Jana , Prešern Janez , Bubnič Jernej , Lužaić Ras , Pihler Ivan , Mirjanić Goran , Pietropaoli Marco , Puškadija Zlatko 
Published: September 2024

Abstract

Background
Research into the genetic diversity of honey bee (Apis melliferaL.) populations has become increasingly significant in recent decades, primarily due to population declines attributed to human activities and climate change. As a species of great importance, breeding programs that leverage understanding of genomic diversity could offer solutions to mitigate these challenges. The objective of this study was to examine the genomic diversity and population structure of Carniolan honey bees (Apis mellifera carnica) using the Illumina SNP chip on a large honey bee sample collected from Central and South-Eastern European countries. The study also aims to offer recommendations for future breeding programs.

Results
Our analysis involved Discriminant Analysis of Principal Components (DAPC), heterozygosity, admixture analysis, fixation indices (FST), Neighbour-Joining tree, gene flow and Isolation-by-distance analysis. DAPC indicated distinct separation between the Carniolan and Italian honey bee (Apis mellifera ligustica) populations, whereas the admixture analysis revealed varying levels of gene flow and genetic admixture within the Carniolan honey bee populations, demonstrating closer relationships between specific geographic regions (confirmed by Isolation-by-distance analysis). Furthermore, the research of heterozygosity, genomic inbreeding, pairwise FST values, and Neighbour-Joining tree provided insights into the patterns of genetic differentiation and similarity among the populations of Carniolan honey bee within its natural habitat. We have observed genetic homogeneity of the Carniolan honey bee population when considered in a broader genetic/geographical context. However, the Carniolan honey bee has sufficient genetic diversity in its geographical home range that needs to be carefully monitored and maintained.

Conclusions
This study provides important insights into the genetic composition, differentiation, and relationships among Carniolan honey bee populations in Central and South-Eastern European countries. The findings are crucial for conservation efforts, breeding programs, and sustainable beekeeping practices. They emphasise the importance of considering genetic factors and population structure in the breeding and management of honey bees. By understanding these genetic relationships, we can develop strategies to preserve genetic diversity, improve breeding outcomes, and ensure the resilience of honey bee populations in the face of environmental changes and challenges. This knowledge can also inform policy makers and stakeholders on best practices to maintain healthy bee populations, which are vital for ecosystem services and agricultural productivity.
Mirror, mirror on my screen: Focus on self-presentation on social media is associated with perfectionism and disordered eating among adolescents. Results from the “LifeOnSoMe”-study
Authors: Danielsen Hilde Einarsdatter , Finserås Turi Reiten , Andersen Amanda Iselin Olesen , Hjetland Gunnhild Johnsen , Woodfin Vivian , Skogen Jens Christoffer 
Published: September 2024

Abstract
Background
Social media use, perfectionism, and disordered eating have all increased over the last decades. Some studies indicate that there is a relationship between self-presentation behaviors and being exposed to others’ self-presentation on social media, and disordered eating. Studies also show that the relationship between focus on self-presentation and highly visual social media is stronger than for non-visual social media, hence facilitating upward social comparison. Nevertheless, no previous studies have investigated the link between adolescents’ focus on self-presentation and upward social comparison on social media, and perfectionism and disordered eating, which is the aim of the present study.

Method
The present study is based on a cross-sectional survey from the “LifeOnSoMe”-study (N = 3424), conducted in 2020 and 2021. Respondents were high school students (mean age 17.3 years, 56% females) in Bergen, Norway. Multiple regression analysis was performed, where SPAUSCIS, a measure of self-presentation and upward social comparison, was the independent variable. Perfectionism and disordered eating were dependent variables. Self-reported age, gender, and subjective socioeconomic status were used as covariates, as well as frequency and duration of social media use. Regression models were performed to compare proportions across the median split of SPAUSCIS.

Results
The multiple regression analysis showed that increased focus on self-presentation and upward social comparison on social media were positively associated with both perfectionism (standardized coefficient 0.28) and disordered eating. A stronger association for girls than boys was found for disordered eating (standardized coefficient 0.39 for girls and 0.29 for boys). There was no gender moderation for perfectionism.

Conclusions
Findings suggest that focus on self-presentation and upward social comparison on social media is associated with perfectionism and disordered eating. We recommend promoting a healthy use of social media. This could be established by increasing adolescents’ ability to reflect on and think critically about self-presentation and upward social comparison on social media.
Novel approach to exploring protease activity and targets in HIV-associated obstructive lung disease using combined proteomic-peptidomic analysis
Authors: Samorodnitsky Sarah , Kruk Monica , Lock Eric F. , Kunisaki Ken M. , Morris Alison , Leung Janice M. , Weise Danielle , Mehta Subina , Parker Laurie L. , Jagtap Pratik D. , Griffin Timothy J. , Wendt Chris H. 
Published: September 2024

Abstract
Background
Obstructive lung disease (OLD) is increasingly prevalent among persons living with HIV (PLWH). However, the role of proteases in HIV-associated OLD remains unclear.

Methods
We combined proteomics and peptidomics to comprehensively characterize protease activities. We combined mass spectrometry (MS) analysis on bronchoalveolar lavage fluid (BALF) peptides and proteins from PLWH with OLD (n = 25) and without OLD (n = 26) with a targeted Somascan aptamer-based proteomic approach to quantify individual proteases and assess their correlation with lung function. Endogenous peptidomics mapped peptides to native proteins to identify substrates of protease activity. Using the MEROPS database, we identified candidate proteases linked to peptide generation based on binding site affinities which were assessed via z-scores. We used t-tests to compare average forced expiratory volume in 1 s per predicted value (FEV1pp) between samples with and without detection of each cleaved protein and adjusted for multiple comparisons by controlling the false discovery rate (FDR).

Findings
We identified 101 proteases, of which 95 had functional network associations and 22 correlated with FEV1pp. These included cathepsins, metalloproteinases (MMP), caspases and neutrophil elastase. We discovered 31 proteins subject to proteolytic cleavage that associate with FEV1pp, with the top pathways involved in small ubiquitin-like modifier mediated modification (SUMOylation). Proteases linked to protein cleavage included neutrophil elastase, granzyme, and cathepsin D.

Interpretations
In HIV-associated OLD, a significant number of proteases are up-regulated, many of which are involved in protein degradation. These proteases degrade proteins involved in cell cycle and protein stability, thereby disrupting critical biological functions.