bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Trace Dance Leaves Is Air: On Steve Paxton (1939–2024)
Authors: Lemon Ralph 
Published: September 2024

Abstract
Artist, writer, and choreographer Ralph Lemon tangentially marks his life in dance through an account of the times he witnessed the work of an important artistic guide, Steve Paxton, a founding member of Judson Dance Theater (1962–64) and Grand Union (1970–76), two collectives that indelibly redefined dance for the following decades. In addition to composing major works, while involved with Grand Union Paxton first formulated the dance form known as contact improvisation, which has become influential worldwide. “The Trace Dance Leaves Is Air” is a personal reflection and tribute, honoring a major artist, while also questioning how much one can trust creative inspiration.
The Tragedy of Dionysus in Euripides’ Bacchae
Authors: Duplessie Derek 
Published: September 2024

Abstract
This article argues for the significance of Euripides’ Bacchae to what Socrates, in Book X of the Republic, refers to as the ‘ancient quarrel between philosophy and poetry’. I argue that the play’s presentation of Dionysus – the god of tragic theatre – amounts to a metapoetic treatment of tragic poetry; it is a tragedy about tragedy. The Bacchae can thus be read as a statement of tragic poetry’s self-understanding of its pedagogical and political goals as well as of its possible limitations. I conclude by arguing that there is in fact a deep kinship between tragic poetry (as presented by Euripides) and Socratic political philosophy (as presented by Plato), especially with respect to their relation to, and understanding of, the polis. Ultimately, through analyzing the Bacchae’s presentation of Dionysus, I aim to allow tragic poetry to speak for itself as well as to clarify its relation to Platonic/Socratic political philosophy.
Picture this: Men building intimate partner relationships
Authors: Oliffe John L , Gao Nina , Kelly Mary T , Shim Andrea , Yap Celene YL , Sharp Paul , McKenzie Sarah 
Published: September 2024

Objectives: The quality of intimate partner relationships strongly influences men’s mental health, yet little research attention has been given to these relationships from a strengths-based critical masculinities perspective. Addressing this knowledge gap, this photovoice study provides insights into young men’s experiences of, and perspectives about, building intimate partner relationships. Design: Photovoice methodology. Setting: This study was conducted virtually over Zoom. Method: Working with 120 participant-produced photographs from 64 men who resided in 13 countries, who and ranged in age from 19 to 43 years ( M = 29.5), the current photovoice study provides a thematic analysis. Results: Three themes were derived. The first of these, Balancing autonomy and coupledom, stressed men’s openness to making and communicating ongoing partnership adjustments. Predominately sharing identity and social connection examples, men spoke to the need to retain a degree of individual agency while meeting joint expectations within a relationship. The second theme, Building compatibility and mutuality, highlighted men’s congruence with their partner as the foundation for actively being together. Flowing from this, mutuality was idealised as jointly bringing about gender equality and gender equity to sustain a relationship through inevitable ups and downs. The third theme, Communicating intimacy, was best accomplished by men having regular discussions with partners to express their affections, and to understand and meet each other’s sexual and emotional needs. Central to nourishing intimacy was a closeness, often garnered by men’s intentional efforts to secure secluded couple-orientated experiences. Conclusion: The findings question stereotypes depicting men as inept in, or ambivalent about, their partnerships. Instead they offer insight into wide-ranging strength-based relational masculinities that enable young men to build intimate partner relationships.
Case series on monoclonal antibodies targeting calcitonin gene-related peptide in migraine patients during pregnancy: Enhancing safety data
Authors: Elosua-Bayes Iker , Alpuente Alicia , Melgarejo Laura , Caronna Edoardo , Torres-Ferrús Marta , Pozo-Rosich Patricia 
Published: September 2024

Background Monoclonal antibodies targeting calcitonin gene-related peptide (CGRP-mAbs) are approved for adult migraine prevention but pose safety concerns in pregnancy. We assess the safety of CGRP-mAbs in the periconceptional period through a case series and literature review. Methods Six migraine-diagnosed women received CGRP-mAbs; treatment ceased upon pregnancy. We collected data and conducted safety assessments. To provide a comprehensive context, we performed a literature review. Results The series includes three erenumab, two fremanezumab and one galcanezumab case. A fremanezumab recipient experienced miscarriage; severe perinatal asphyxia linked to dystocia occurred with erenumab (140 mg). Database reviews revealed 63 spontaneous abortions, eight premature births, and seven birth defects among 286 World Health Organization and 65 European Medicines Agency cases. These rates align with untreated population rates. Conclusions CGRP-mAbs use in the periconceptional period does not lead to clinically significant increase in pregnancy-related pathology or adverse effects on newborns within our case series and the literature reviewed.
Umbelliprenin improved anti-proliferative effects of ionizing radiation on adult T-cell leukemia/lymphoma cells via interaction with CDK6; an in vitro and in silico study
Authors: Ebrahimi Keyhan , Bagheri Ramin , Gholamhosseinian Hamid , Keramati Mohammad Reza , Rafatpanah Houshang , Iranshahi Mehrdad , Rassouli Fatemeh B 
Published: September 2024

Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy with poor survival rates. The efficacy of radiotherapy in ATL needs enhancement with radiosensitizing agents. This study investigated whether umbelliprenin (UMB) could improve the therapeutic effects of ionizing radiation (IR) in ATL cells. UMB, a naturally occurring prenylated coumarin, exhibits anticancer properties and has shown synergistic effects when combined with chemotherapeutic drugs. Despite this promising profile, there is a notable lack of research on its potential combinatorial effects with IR, particularly for ATL treatment. UMB was extracted from Ferula persica using thin layer chromatography. MT-2 cells were treated with UMB alone and in combination with various doses of IR, and cell proliferation was assessed via alamarBlue assay. Flow cytometry with annexin V and PI staining was conducted, and candidate gene expression was analyzed by qPCR. In silico analysis involved identifying pathogenic targets of ATL, constructing protein-protein interaction (PPI) networks, and evaluating CDK6 expression in MT-2 cells. Molecular docking was used to determine the interaction between UMB and CDK6. The alamarBlue assay and flow cytometry showed that pretreating ATL cells with UMB significantly ( p < .0001) enhanced anti-proliferative effects of IR. The combination index indicated a synergistic effect between UMB and IR. qPCR revealed significant ( p < .0001) downregulation of CD44, CDK6, c-MYC, and cFLIPL, and overexpression of cFLIPS. Computational analysis identified CDK6 as a hub gene in the PPI network, and CDK6 overexpression was confirmed in MT-2 cells. Molecular docking revealed a favorable binding interaction between UMB and the ATP-binding site of CDK6, with a JAMDA score of −2.131, surpassing the control selonsertib. The current study provides evidence that UMB enhances the anti-proliferative effects of IR on ATL cells, and highlights the significance of targeting CDK6 in combinatorial approaches.
Apixaban as a Secondary Prophylaxis Agent for Patent Foramen Ovale-Associated Stroke
Authors: Khaimova Rebecca M. , Toderika Yuliana , Ramnarain Justin , Donatien Claudette 
Published: September 2024

Background: The purpose of this case report is to describe a case of switching warfarin to apixaban in a patient on anticoagulant prophylaxis for a patent foramen ovale (PFO)-associated stroke. Case Summary: An 86-year-old Afro-Latina female with a past medical history of cerebrovascular accident (CVA) in 2012 secondary to PFO and diagnosed Atrial Fibrillation (AF). Patient was switched from warfarin to apixaban after 3 months of labile international normalized ratio (INR) levels. The patient’s INR was monitored at a pharmacist-led anticoagulation clinic. As the patient’s INR remained subtherapeutic while on warfarin, a shared decision was made to switch the patient to apixaban 2.5 mg twice daily due to consistently painful enoxaparin injections, inconsistent vitamin K intake, frequent clinic visits and unstable renal function. Patient tolerated the anticoagulant switch well and reported satisfaction with decreased clinic visits and variable vitamin K diet. At 12 months post-switch, the patient’s complete blood count remains stable, no reported signs and symptoms of bleeding, and no new CVA or venous thromboembolism (VTE) events identified. Based on an improvement in renal function, the dose was increased to 5 mg twice daily.
Exploring the taken-for-granted relationship between children’s culture and the cultural heritage of terrorism
Authors: Hrechaniuk Yelyzaveta 
Published: September 2024

This article explores the relationship between children’s visual and material cultures and the official cultural heritage of terrorism. Drawings and cuddly toys have become a significant, yet overlooked, part of ‘difficult’ heritage of impactful violent events. The focus is on two museum collections dedicated to the 2017 terrorist attack in Stockholm – the active contributions of young people (8–25 years old) to the collections, and their presences constituted by artefacts. Examining both provides insights into the politics of cultural heritage and how heritage can be produced and presented.
Complications of Operative Treatment of Injuries of Peripheral Arteries
Authors: Velinovic M. Milos , Davidovic B. Lazar , Lotina I. Slobodan , Vranes R. Mile , Djukic L. Petar , Arsov J. Vladislav , Ristic V. Miljko , Kocica J. Mladen , Petrovic Lj. Predrag 
Published: September 2024

In 1991 and 1992, a total of 97 patients with 106 peripherial arterial injuries underwent surgery at the Institute for Cardiovascular Diseases, Clinical Centre of Serbia. Civilian injuries accounted for 53 (54.6%) patients (94.3% males, age range: 16–63 yr, mean: 35.2), and 44 patients had war injuries (93.2% males, age range: 19–61 yr, mean: 34.8). The injuries affected the superfitial femoral artery in 31 (29.24%); the popliteal artery in 28 (26.41%); the brachial artery in 17 (16.04%); the posterior tibial artery in 6 (5.66%); the axillary artery in 5 (4.72%); the anterior tibial artery in 5 (4.72%); the tlbioperoneal trunk in 4 (3.77%); the common femoral artery in 4 (3.77%); the external iliac artery in 2 (1.89%); the profound femoral artery in 2 (1.89%); the radial artery in 1 (0.94%); and ulnar artery in 1 (0.94%). A total of 98 reconstructive procedures were used to treat these patients. Graft interposition carried out in 50 (51.02%); by pass in 25 (25.51%); end-to-end anastomosis in 9 (9.18%); suture in 8 (8.16%); ligation in 4 (4.08%); and patch-angioplasty in 2 (2.04%). Primary reconstruction of injured arteries was performed in 72.2% and secondary repair in 27.8% cases. Infection developed in 51 (52.57%) patients, and it was significantly ( P < 0.05) more common in the war injuries (70.45%) and in secondary repairs (88.89%). The presence of associated lesions (69.56%) was also correlated with a greater rate of infection. Amputation was necessary in 21 (21.65%) of our patients, and was significantly ( P < 0.05) more often performed after secondary (44.44%) than primary operations (12.86%) and in the presence of associated injuries (32.61%).
Lack of Compressibility of the Common Femoral Vein: An Unequivocal Sign of Proximal Deep Venous Thrombosis on Duplex Ultrasound?
Authors: De Maeseneer M. G. , Tielliu I. F. , Tjalma W. A. , Van Schil P. E. 
Published: September 2024

The authors report a case of false positive diagnosis of iliac vein thrombosis on duplex ultrasound. The misreading of the duplex scan was based on the presence of an incompressible common femoral vein. External compression on the iliac veins, caused by enormous postoperative lymphoceles, was responsible for the false positive diagnosis.
Aortic Reconstructive Surgery for Limb Ischaemia: Immediate and Long-Term Follow-Up to Provide a Standard for Endovascular Procedures
Authors: Harris R.A. , Hardman D.T.A. , Fisher C. , Lane R. , Appleberg M. 
Published: September 2024

Purpose: Aortobifemoral and aortobiliac bypass has been a preferred treatment of severe aortoiliac occlusive disease. Recently, endovascular procedures and unilateral bypass grafting have been introduced. We report the results of aortic reconstructive surgery over a 19-year period (1975–1994). Methods: A total of 285 patients underwent surgery. Follow-up data from clinical notes, general practitioner questionnaire or phone interview was available in 93.3% (266/285). Results: Of the total 68% were male (180/226) and the median age was 63 years (range 22–85 years). Indications for surgery were tissue loss/gangrene ( n = 32), rest pain ( n = 84), severe claudication ( n = 40), moderate claudication ( n = 110). Total of 177 bifurcated grafts, 51 iliofemoral, eight left/right aortofemoral, and 30 other procedures were performed. The median duration of follow-up was 49.8 months. Cumulative secondary graft patency for 2, 5 and 10 years was 97.7%, 95.9%, and 94.4%. The amputation rate was 4.5% (12/266). Early mortality occurred in eight of 266 patients (3%) and late mortality in 60 patients. The most common cause of late death was ischaemic heart disease (24/60 followed by cancer (14/60). Data was further analysed by type of graft, risk factors, complications and previous and subsequent surgery. In our experience, aortic reconstructive surgery is a successful option for the management of severe aortoiliac occlusive disease. The outcome of other methods of maintaining arterial patency should be measured against this standard.
Increasing the Colloid Osmotic Pressure of Cardiopulmonary Bypass Prime and Normothermic Blood Cardioplegia Minimizes Myocardial Oedema and Prevents Cardiac Dysfunction
Authors: Mehlhorn U. , Allen S. J. , Davis K. L. , Geissler H. J. , Waiters R. D. , de Vivie E. Rainer 
Published: September 2024

Our recent work demonstrated that normothermic continuous antegrade blood cardioplegia results in cardiac dysfunction related to myocardial oedema. This oedema was partially due to increased myocardial microvascular fluid filtration induced by crystalloid hemodilution. We hypothesized that increasing the colloid osmotic pressure of blood cardioplegia would stop fluid filtration into the cardiac interstitium, thus preventing myocardial oedema and cardiac dysfunction. Methods: We determined myocardial water content in six dogs by microgravimetry and myocardial lymph flow from the major prenodal cardiac lymphatic. Preload recruitable stroke work was derived from sonomicrometry and micromanometry. The dogs were subjected to normothermic cardiopulmonary bypass primed with 6% hetastarch and 1 h of normothermic continuous antegrade blood cardioplegia (4:1 blood:6% hetastarch colloid osmotic pressure 21 ± 2 mmHg) delivered at 50 mmHg perfusion pressure. Results: We found that despite increased colloid osmotic pressure, a small but significant increase in myocardial water content still occurred during blood cardioplegia. As myocardial Jymph flow virtually ceased during cardioplegia, myocardial microvascular filtration must have been present. However, increased myocardial lymph flow following cardioplegia resulted in complete oedema resolution associated with normal left ventricular performance post-cardiopulmonary bypass. Conclusions: Our data show that the plegic myocardium is prone to oedema formation because of both relatively enhanced fluid filtration and lymph flow cessation. We conclude that increasing the colloid osmotic pressure of normothermic blood cardioplegia minimizes myocardial oedema, thus preventing post-cardiopulmonary bypass cardiac dysfunction.
Extraperitoneal Laparoscopic Aortic Control with Endovascular Visualization of a Stent-Graft Combination
Authors: Andrews S. M. , Freestone T. , Pate P. , Greenhalgh R. M. , Nott D. M. 
Published: September 2024

Objectives: To demonstrate the feasibility of minimally invasive approaches to the aorta using retroperitoneal laparoscopy and to clamp the aorta to give views for perfemoral aortic angioscopy. Methods: Using retroperitoneal laparoscopy facilitated by balloon dissection the authors developed a new approach to the infrarenal abdominal aorta, in six pigs, to allow control of aortic blood flow. Aortic stent-grafts were then deployed via femoral arteriotomy, and after flushing the blood from the aorta, the stent-grafts were visualized by angioscopy. Results: Accurate positioning and patency of the stent-grafts was ascertained by direct vision angioscopy in all cases. Conclusions: This series shows that extraperitoneal laparoscopic aortic dissection is feasible and direct endovascular visualization of the aortic lumen can be performed. This may find a role as an adjunct to endovascular techniques such as endovascular stent-graft placement, by aortic angioscopy following minimally-invasive aortic clamping.
Regulations of Immune Response by Astragalus  in Animal Asthma Models: A Meta-analysis
Authors: Wang Song , Chen Xinhua , Shi Zuoqiao , Shen Qianqian , Li Jing , Hua Wang , Shujing Wang , Wu Wanjing , Xi Qing , Li Guowen 
Published: September 2024

Background Asthma is a chronic respiratory condition by airway inflammation. Traditional Chinese medicine, is commonly used to treat it. Astragalus is known for its immunoregulation, anti-inflammatory, and antioxidant effects. Purpose To systematically evaluate the efficacy of Astragalus in asthma animal models using meta-analysis methods. Methodology A systematic search was performed in various databases, such as China National Knowledge Infrastructure (CNKI), WanFang Data, PubMed, Web of Science, and Cochrane Library databases for animal studies on Astragalus intervention in asthma models, with the search period extending up to September 2023. Two researchers performed independent literature screening and data extraction. The quality of the included studies was assessed by the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) animal experiment bias risk assessment tool. Meta-analysis was performed with RevMan (version 3.6.1). Results A total of 25 experiments were included. Meta-analysis indicated that Astragalus can significantly reduce total leukocytes, neutrophils, lymphocytes, and eosinophils in animal models of asthma. It also downregulated the expression levels of interleukin-4 and interleukin-5, while upregulation of interferon-γ and interleukin-10 expression was observed; however, the impact on macrophages was found to be not statistically significant ( p > 0.05). Conclusion Our systemic review suggested the potential efficiency of Astragalus in asthma treatment in China, although its mechanism is still unclear. The functions of Astragalus may be associated with attenuating airway inflammation through the regulation of immune response.
Research Trends in Presurgical Infant Orthopaedic Treatment in Patients with Cleft Lip and Palate: A Bibliometric Analysis of 100 Most-Cited Articles
Authors: Sennimalai Karthik , Selvaraj Madhanraj , Sameemullah Kathijathul Hidhaya , Gothankar Greeshma Shantharam , Siddiqui Hamza Parvez , Arora Garima , Mohaideen Kaja 
Published: September 2024

Objective To assess research trends and publication patterns of literature related to presurgical infant orthopaedics (PSIO) through a bibliometric analysis of the top 100 most-cited articles. Material and methods The top 100 most-cited articles were identified in the Web of Science (WoS) database using search terms related to PSIO on April 23, 2024, without any restrictions to study design, publication date and language. Standard information about each study was extracted. Citations from WoS, Scopus and PubMed databases were compared. The level of evidence for each article included was assessed. Association between different variables was calculated using Spearman's correlation coefficient with statistical significance set at p < 0.05. Visual analysis of the author's keyword co-occurrence, co-authorship analysis of authors, and citation analysis of journals and authors were performed using VOSviewer. Results Top cited articles were published from 1994 to 2020, with total individual database citations being WoS (n = 5378), Scopus (n = 6184) and PubMed (n =  10 450). Eleven articles were considered classic articles. Cleft Palate and Craniofacial Journal (Impact Factor = 1.1) had a maximum number of articles and citations. Two hundred eighty-five individuals contributed to top-cited articles, with 62 corresponding authors from 19 countries. A maximum number of authors were affiliated with universities in the United States. The most common keyword used was “nasoalveolar molding (n = 24)”, “cleft palate (n = 16)”, and “infant orthopedics (n = 16)”. The study design of the majority of articles was retrospective and follow-up studies (level 3; n = 53). A weak negative correlation was observed between citation metrics and both the publication year ( P < 0.01) and the level of evidence ( P < 0.01). Conclusion This analysis recognises the contributions of experts and offers valuable insights into trends that have shaped the development and evidence related to PSIO research. Future research should focus on integrating advanced technologies, conducting longitudinal studies, fostering collaboration, and emphasizing patient-centred outcomes.
Survival predictors in patients with pancreatic cancer on liposomal irinotecan plus fluorouracil/leucovorin: a multicenter observational study
Authors: Keum Jiyoung , Lee Hee Seung , Park Chan Su , Kim Jeehoon , Jang Wonjoon , Shin Kyung In , Kang Huapyong , Lee Sang Hoon , Jo Jung Hyun , Jang Sung Ill , Chung Moon Jae , Park Jeong Youp , Park Seung Woo , Cho Jae Hee , Bang Seungmin 
Published: September 2024

Background: Approximately half of the patients with advanced pancreatic ductal adenocarcinoma (PDAC) receive subsequent lines of chemotherapy. Recently, the liposomal irinotecan (nal-IRI) plus 5-fluorouracil/leucovorin (5-FU/LV) regimen is recommended as subsequent lines of chemotherapy. However, little is known about the predictive factors for the nal-IRI + 5-FU/LV regimen, especially in patients with previous irinotecan (IRI) exposure. Objectives: We investigated the predictive factors associated with nal-IRI + 5-FU/LV treatment in patients with PDAC. Design: Multicenter, retrospective cohort study. Methods: This study included patients with advanced PDAC who received the nal-IRI + 5-FU/LV regimen for palliative purposes. Results: Overall, 268 patients were treated with nal-IRI + 5-FU/LV. The median overall survival (OS) was 7.9 months (95% confidence interval (CI): 7.0–8.8), while the median progression-free survival (PFS) was 2.6 months (95% CI: 1.9–3.2). An albumin level of<4.0 g/dL, neutrophil-to-lymphocyte ratio (NLR) of ⩾3.5, liver or peritoneal metastasis, and a history of >3 lines of palliative chemotherapy were associated with worse OS. An NLR of ⩾3.5 and liver metastasis were significant predictive factors for worse PFS. Previous exposure to IRI was not a significant predictor. Patients without prior IRI (no-IRI) treatment showed relatively longer OS and PFS compared to IRI responders and nonresponders, but these differences were not significant when compared specifically to the responders (OS: 8.8 vs 8.1 months, p = 0.388; PFS: 3.6 vs 2.6 months, p = 0.126). Conclusion: An NLR of ⩾3.5 and liver metastasis were associated with worse PFS. Prior IRI exposure was not a significant predictive factor for OS and PFS, especially in IRI responders.