bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teiichi Kobayashi: his life and works, with an emphasis on his contribution to the history of the geosciences in Japan
Authors: Sato T. , Yamada T. , Yajima M. 
Published: November 2016

Abstract

Teiichi Kobayashi (1901–96), a major figure in the history of Japanese geology and palaeontology, was one of the founding members of INHIGEO. He is best known for his work on the Sakawa orogenic cycle and its bearing on the origin of the Japanese islands, which was published in 1941. He researched the geology and palaeontology of the Palaeozoic in East and SE Asia between 1964 and 1984 and published work on cephalopods and trilobites in Asia. During his research, he always recognized the importance of the history of the geological sciences. In 1972, he proposed and organized a committee dedicated to the history of the Japanese geosciences. Based on his awareness of the social significance of the geosciences and their history in Japan, he also contributed to the promotion of
Chigaku
(earth science) education in high schools and in universities.
A look into the history of geology in France
Authors: Taquet Philippe 
Published: November 2016

Abstract
The history of geology in France benefited from a renewal of interest after the creation of the French Committee for the History of Geology in 1976. This initiative, which was led by F. Ellenberger, resulted in the organization of numerous meetings, symposia and publications that have characterized the last decade of work in the history of the earth sciences in France.
Progression of instrument use and practice in mineralogy and petrology, 1750–1950
Authors: Newcomb Sally 
Published: November 2016

Abstract
Although laboratory practice has changed enormously over the last two centuries, it is more a matter of the addition of instruments and methods than their replacement. Balances, microscopes, thermometers and methods of applying pressure are still used. The analysis and characterization of the constituents of rocks and minerals continue to be of basic and necessary interest. Some methods have changed and others, previously unavailable, are now accessible. Each natural philosopher–mineralogist–geologist made use of the instrumentation available, often extending its use or improving it to meet their needs.
A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents
Authors: Azan Antoine , Caspers Peter J. , Bakker Schut Tom C. , Roy Séverine , Boutros Céline , Mateus Christine , Routier Emilie , Besse Benjamin , Planchard David , Seck Atmane , Kamsu Kom Nyam , Tomasic Gorana , Koljenović Senada , Noordhoek Hegt Vincent , Texier Matthieu , Lanoy Emilie , Eggermont Alexander M.M. , Paci Angelo , Robert Caroline , Puppels Gerwin J. , Mir Lluis M. 
Published: November 2016

Abstract
Raman spectroscopy is a noninvasive and label-free optical technique that provides detailed information about the molecular composition of a sample. In this study, we evaluated the potential of Raman spectroscopy to predict skin toxicity due to tyrosine kinase inhibitors treatment. We acquired Raman spectra of skin of patients undergoing treatment with MEK, EGFR, or BRAF inhibitors, which are known to induce severe skin toxicity; for this pilot study, three patients were included for each inhibitor. Our algorithm, based on partial least squares-discriminant analysis (PLS-DA) and cross-validation by bootstrapping, discriminated to variable degrees spectra from patient suffering and not suffering cutaneous adverse events. For MEK and EGFR inhibitors, discriminative power was more than 90% in the viable epidermis skin layer; whereas for BRAF inhibitors, discriminative power was 71%. There was a 81.5% correlation between blood drug concentration and Raman signature of skin in the case of EGFR inhibitors and viable epidermis skin layer. Our results demonstrate the power of Raman spectroscopy to detect apparition of skin toxicity in patients treated with tyrosine kinase inhibitors at levels not detectable via dermatological inspection and histological evaluation. Cancer Res; 77(2); 557–65. ©2016 AACR.
Gene Targeting Meets Cell-Based Therapy: Raising the Tail, or Merely a Whimper?
Authors: Cogdill Alexandria P. , Prieto Peter A. , Reuben Alexandre , Wargo Jennifer A. 
Published: November 2016

Abstract
Appreciation of the immune effects of targeted agents has grown, and efforts to combine these agents with immunotherapy are underway to enhance therapeutic responses. Multiple ongoing trials are examining this concept; however, nuances exist with regard to timing, sequence, and combinatorial strategies. Clin Cancer Res; 23(2); 327–9. ©2016 AACR.
See related article by Deniger et al., p. 351
Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers
Authors: Arora Arvind , Parvathaneni Swetha , Aleskandarany Mohammed A. , Agarwal Devika , Ali Reem , Abdel-Fatah Tarek , Green Andrew R. , Ball Graham R. , Rakha Emad A. , Ellis Ian O. , Sharma Sudha , Madhusudan Srinivasan 
Published: November 2016

Abstract
RECQL1, a key member of the RecQ family of DNA helicases, is required for DNA replication and DNA repair. Two recent studies have shown that germline RECQL1 mutations are associated with increased breast cancer susceptibility. Whether altered RECQL1 expression has clinicopathologic significance in sporadic breast cancers is unknown. We evaluated RECQL1 at the transcriptomic level (METABRIC cohort, n = 1,977) and at the protein level [cohort 1, n = 897; cohort 2, n = 252; cohort 3 (BRCA germline deficient), n = 74]. In RECQL1-depleted breast cancer cells, we investigated anthracycline sensitivity. High RECQL1 mRNA was associated with intClust.3 (P = 0.026), which is characterized by low genomic instability. On the other hand, low RECQL1 mRNA was linked to intClust.8 [luminal A estrogen receptor–positive (ER+) subgroup; P = 0.0455] and intClust.9 (luminal B ER+ subgroup; P = 0.0346) molecular phenotypes. Low RECQL1 expression was associated with shorter breast cancer–specific survival (P = 0.001). At the protein level, low nuclear RECQL1 level was associated with larger tumor size, lymph node positivity, high tumor grade, high mitotic index, pleomorphism, dedifferentiation, ER negativity, and HER-2 overexpression (P &lt; 0.05). In ER+ tumors that received endocrine therapy, low RECQL1 was associated with poor survival (P = 0.008). However, in ER− tumors that received anthracycline-based chemotherapy, high RECQL1 was associated with poor survival (P = 0.048). In RECQL1-depleted breast cancer cell lines, we confirmed doxorubicin sensitivity, which was associated with DNA double-strand breaks accumulation, S-phase cell-cycle arrest, and apoptosis. We conclude that RECQL1 has prognostic and predictive significance in breast cancers. Mol Cancer Ther; 16(1); 239–50. ©2016 AACR.
Digitalis-like Compounds Facilitate Non-Medullary Thyroid Cancer Redifferentiation through Intracellular Ca2+, FOS, and Autophagy-Dependent Pathways
Authors: Tesselaar Marika H. , Crezee Thomas , Swarts Herman G. , Gerrits Danny , Boerman Otto C. , Koenderink Jan B. , Stunnenberg Hendrik G. , Netea Mihai G. , Smit Johannes W.A. , Netea-Maier Romana T. , Plantinga Theo S. 
Published: November 2016

Abstract
Up to 20%–30% of patients with metastatic non-medullary thyroid cancer have persistent or recurrent disease resulting from tumor dedifferentiation. Tumor redifferentiation to restore sensitivity to radioactive iodide (RAI) therapy is considered a promising strategy to overcome RAI resistance. Autophagy has emerged as an important mechanism in cancer dedifferentiation. Here, we demonstrate the therapeutic potential of autophagy activators for redifferentiation of thyroid cancer cell lines. Five autophagy-activating compounds, all known as digitalis-like compounds, restored hNIS expression and iodide uptake in thyroid cancer cell lines. Upregulation of hNIS was mediated by intracellular Ca2+ and FOS activation. Cell proliferation was inhibited by downregulating AKT1 and by induction of autophagy and p21-dependent cell-cycle arrest. Digitalis-like compounds, also designated as cardiac glycosides for their well-characterized beneficial effects in the treatment of heart disease, could therefore represent a promising repositioned treatment modality for patients with RAI-refractory thyroid carcinoma. Mol Cancer Ther; 16(1); 169–81. ©2016 AACR.
Impact of Cost Sharing on Therapeutic Substitution: The Story of Statins in 2006
Authors: Li Pengxiang , Schwartz J. Sanford , Doshi Jalpa A. 
Published: November 2016

Background
Cost sharing is widely used to encourage therapeutic substitution. This study aimed to examine the impact of increases in patient cost‐sharing differentials for brand name and generic drugs on statin utilization on entry into the Medicare Part D coverage gap.

Method and Results

Using 5% Medicare Chronic Condition Warehouse files from 2006, this quasi‐experimental study examined patients with hyperlipidemia who filled prescriptions for atorvastatin or rosuvastatin between January and March 2006. Propensity score matching and difference‐in‐difference regressions were used to compare changes in statin utilization for the study group (patients who were not eligible for low‐income subsidies [non–
LIS
] and had generic‐only gap coverage) to those of a control group (
LIS
patients who faced the same cost sharing before and during the Part D coverage gap). In the final sample, 801 patients in the study group were matched to 801 patients in the control group. We found that, compared to the control group, the study group had a larger decline in any monthly brand‐name statin use (−0.24 30‐day fills,
P
<0.001). This was only partially offset by increased monthly generic statin use (+0.06 30‐day fill,
P
<0.001), with an overall drop in any monthly statin use (−0.18 30‐day fills,
P
<0.001). Overall adherence with statins declined (
OR
0.81,
P
<0.001), and statin discontinuation increased (
OR
1.62,
P
<0.001) in the study group as compared to the control group.

Conclusions
Increases in cost‐sharing differentials for brand name and generic drugs on coverage gap entry were associated with discontinuation of statins in Medicare Part D patients with hyperlipidemia.
Evaluation of a pharmacy managed heparin protocol for extracorporeal membrane oxygenation patients
Authors: Fitousis Kalliopi , Klasek Robin , Mason Phillip E , Masud Faisal 
Published: November 2016

Introduction: Unfractionated heparin is the preferred anticoagulant in extracorporeal membrane oxygenation (ECMO) patients. However, there is a lack of consensus on its titration and monitoring. The objective of this study was to describe the efficacy and safety of a pharmacy managed heparin protocol utilizing activated partial thromboplastin time (aPTT) in comparison to our standard physician-managed activated clotting time (ACT)-based anticoagulation in ECMO patients. Methods: Patients administered a heparin drip while on ECMO were included in the study. The primary endpoints were the incidence of hemorrhagic and thrombotic complications. Results: A total of 122 adult patients were identified who were on ECMO with heparin anticoagulation; sixty-one patients were managed with each of the physician-managed ACT and pharmacy managed aPTT protocols. No statistically significant difference was observed between the physician ACT and the pharmacy aPTT groups in overall hemorrhagic (69% vs 80%, p=0.145) or thrombotic complications (41% vs 39%, p=0.853). Conclusion: There was a similar rate of thrombotic and bleeding events between the two study groups. A pharmacy managed heparin protocol utilizing aPTT monitoring appears to be a safe and effective method of providing anticoagulation in adult ECMO patients.
Identifying professionals’ needs in integrating electronic pain monitoring in community palliative care services: An interview study
Authors: Taylor Sally , Allsop Matthew J , Bekker Hilary L , Bennett Michael I , Bewick Bridgette M 
Published: November 2016

Background: Poor pain assessment is a barrier to effective pain control. There is growing interest internationally in the development and implementation of remote monitoring technologies to enhance assessment in cancer and chronic disease contexts. Findings describe the development and testing of pain monitoring systems, but research identifying the needs of health professionals to implement routine monitoring systems within clinical practice is limited. Aim: To inform the development and implementation strategy of an electronic pain monitoring system, PainCheck, by understanding palliative care professionals’ needs when integrating PainCheck into routine clinical practice. Design: Qualitative study using face-to-face interviews. Data were analysed using framework analysis Setting/participants: Purposive sample of health professionals managing the palliative care of patients living in the community Results: A total of 15 interviews with health professionals took place. Three meta-themes emerged from the data: (1) uncertainties about integration of PainCheck and changes to current practice, (2) appraisal of current practice and (3) pain management is everybody’s responsibility Conclusion: Even the most sceptical of health professionals could see the potential benefits of implementing an electronic patient-reported pain monitoring system. Health professionals have reservations about how PainCheck would work in practice. For optimal use, PainCheck needs embedding within existing electronic health records. Electronic pain monitoring systems have the potential to enable professionals to support patients’ pain management more effectively but only when barriers to implementation are appropriately identified and addressed.
Middle cerebral artery diameter changes during rhythmic handgrip exercise in humans
Authors: Verbree J , Bronzwaer AGT , van Buchem MA , Daemen MJAP , van Lieshout JJ , van Osch MJP 
Published: November 2016

Transcranial Doppler (TCD) sonography is a frequently employed technique for quantifying cerebral blood flow by assuming a constant arterial diameter. Given that exercise increases arterial pressure by sympathetic activation, we hypothesized that exercise might induce a change in the diameter of large cerebral arteries. Middle cerebral artery (MCA) cross-sectional area was assessed in response to handgrip exercise by direct magnetic resonance imaging (MRI) observations. Twenty healthy subjects (11 female) performed three 5 min bouts of rhythmic handgrip exercise at 60% maximum voluntary contraction, alternated with 5 min of rest. High-resolution 7 T MRI scans were acquired perpendicular to the MCA. Two blinded observers manually determined the MCA cross-sectional area. Sufficient image quality was obtained in 101 MCA-scans of 19 subjects (age-range 20–59 years). Mixed effects modelling showed that the MCA cross-sectional area decreased by 2.1 ± 0.8% (p = 0.01) during handgrip, while the heart rate increased by 11 ± 2% (p < 0.001) at constant end-tidal CO2 (p = 0.10). In conclusion, the present study showed a 2% decrease in MCA cross-sectional area during rhythmic handgrip exercise. This further strengthens the current concept of sympathetic control of large cerebral arteries, showing in vivo vasoconstriction during exercise-induced sympathetic activation. Moreover, care must be taken when interpreting TCD exercise studies as diameter constancy cannot be assumed.
Computed tomography is not necessary to assess rotation of the femoral component in navigation-assisted total knee replacement
Authors: Hernández-Vaquero Daniel , Noriega-Fernandez Alfonso , Perez-Coto Ivan , Sandoval García Manuel A. , Sierra-Pereira Andres A. , Roncero-Gonzalez Sergio , Fernandez-Carreira Jose Manuel 
Published: November 2016

Objective To demonstrate that postoperative computed tomography (CT) is not needed if navigation is used to determine the rotational position of the femoral component during total knee replacement (TKR). Methods Preoperative CT, navigational, and postoperative CT data of 70 TKR procedures were analysed. The correlation between the rotational angulation of the femur measured by CT and that measured by perioperative navigation was examined. The correlation between the femoral component rotation determined by navigation and that determined by CT was also assessed. Results The mean femoral rotation determined by navigation was 2.64° ± 4.34°, while that shown by CT was 6.43° ± 1.65°. Postoperative rotation of the femoral component shown by CT was 3.09° ± 2.71°, which was closely correlated with the angle obtained through the intraoperative transepicondylar axis by navigation (Pearson’s R = 0.930). Conclusions Navigation can be used to collect the preoperative, intraoperative, and postoperative data and final position of the TKR. The rotation of the femoral component can be determined using navigation without the need for CT.
Growth of Headache Research: A 1983–2014 bibliometric study
Authors: Robert Claude , Wilson Concepción S , Lipton Richard B , Arreto Charles-Daniel 
Published: November 2016

Aim This study charts the growth of the scientific journal literature on headache for 30+ years (1983–2014). Methods Using the Web of Science, articles published in four two-year periods (1983–1984, 1993–1994, 2003–2004, 2013–2014) from journals indexed in the Science Citation Index Expanded database were retrieved and analyzed. Results From 1983–1984 to 2013–2014, the scientific literature on headache increased nearly fourfold (3.8) from 468 to 1776 articles; the number of participating countries more than doubled (26 to 67); and the two most prolific countries in each period were the USA and Italy. While several European countries (Italy, Germany, UK and Denmark) were among the top 10 in each period, the notable appearance of Turkey, China and Brazil among the top 10 in 2013–2014 indicates the growing geographic spread of publications on headache research. Meanwhile, the comet-like distribution of journals has not changed: two journals, Headache and Cephalalgia, persist throughout as the nucleus, with the tail increasing more than threefold from 141 journals in 1983–1984 to 462 in 2013–2014. Conclusion Our study follows the recent growth and spread of the scientific literature on headache research and should stimulate further bibliometric investigation in this field.
Protection of resveratrol on acute kidney injury in septic rats
Authors: Gan Y , Tao S , Cao D , Xie H , Zeng Q 
Published: November 2016

Aim: The aim of the study is to investigate protective effect of resveratrol (Res) on acute kidney injury (AKI) in sepsis. Methods: Rats in sham group received sham operation; in sham + Res received sham operation and Res (3 mg/kg); in cecal ligation and puncture (CLP) established as sepsis; in CLP + Res (3 mg/kg) with sepsis and Res (3 mg/kg); and in CLP + Res (10 mg/kg) with sepsis and Res (10 mg/kg). Survival rate, serum indexes, inflammatory factors, NF-κB-P65, and SIRT1 were detected. Lipopolysaccharide (LPS) mesangial cell was with Res and SIRT1 silencing. Results: (1) Res intervention improved survival rate of CLP rat. (2) Compared to sham, serum creatinine, blood urine nitrogen, serum cystatin C, neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, tumor necrosis factor-α, interleukin-1β, IL-6, and renal injury index increased in CLP group, while decreased in CLP + Res (3 mg/kg) and CLP + Res (10 mg/kg), significantly, as dose-dependent ( p < 0.05). (3) With Res, NF-κB-P65 and de-acetylated SIRT1 decreased, while SIRT1 and de-acetylated Nuclear factor kB-p65 9 NF-κB-P65) increased, significantly ( p < 0.05). (4) SIRT1 and de-acetylated NF-κB-P65 decreased in LPS cells, while SIRT1 increased after Res intervention, significantly ( p < 0.05). After silencing SIRT1, de-acetylated NF-κB-P65 increased, significantly ( p < 0.05). Conclusions: Res increases the survival rate of septic rats by inhibiting inflammatory factors to ease AKI and promotes NF-κB-P65 de-acetylation by upregulating SIRT1.
Geographic Variation in California Pediatric Hospice Care for Children and Adolescents: 2007-2010
Authors: Lindley Lisa C. , Edwards Sheri L. 
Published: November 2016

Objective: To map and describe the geographic distribution of pediatric hospice care need versus supply in California over a 4-year time period (2007-2010). Methods: Multiple databases were used for this descriptive longitudinal study. The sample consisted of 2036 children and adolescent decedents and 136 pediatric hospice providers. Geocoded data were used to create the primary variables of interest for this study—need and supply of pediatric hospice care. Geographic information systems were used to create heat maps for analysis. Results: Almost 90% of the children and adolescents had a potential need for hospice care, whereas more than 10% had a realized need. The highest density of potential need was found in the areas surrounding Los Angeles. The areas surrounding the metropolitan communities of Los Angeles and San Diego had the highest density of realized hospice care need. Sensitivity analysis revealed neighborhood-level differences in potential and realized need in the Los Angeles area. Over 30 pediatric hospice providers supplied care to the Los Angeles and San Diego areas. Conclusion: There were distinctive geographic patterns of potential and realized need with high density of potential and realized need in Los Angeles and high density of realized need in the San Diego area. The supply of pediatric hospice care generally matched the needs of children and adolescents. Future research should continue to explore the needs of children and adolescents at end of life at the neighborhood level, especially in large metropolitan areas.
Efficacy of Calcaneus Osteotomy for Treatment of Symptomatic Müller-Weiss Disease
Authors: Li Shu-Yuan , Myerson Mark S. , Monteagudo Manuel , Maceira Ernesto 
Published: November 2016

Background: Various methods of midfoot and hindfoot arthrodesis for treating symptomatic Müller-Weiss disease (MWD) have been reported in the literature. In this study, we present the results of a previously unreported method of treatment using a calcaneal osteotomy incorporating a wedge and lateral translation. Methods: Thirteen patients (14 feet) with MWD were treated with a calcaneal osteotomy and retrospectively reviewed. These included 7 females and 6 males, with an average age of 56 years (33-79 years), and an average symptoms duration of 10.6 years (1-16 years). The disease was staged according to Maceira, which included 5 feet in stage II, 4 feet in stage III, 4 feet in stage IV, and 1 foot in stage V. Pre- and postoperative visual analog scale (VAS) score, American Orthopaedic Foot & Ankle Society (AOFAS), radiologic examination, and patients’ satisfaction rate of the surgery were evaluated at an average of 3.7 years (range, 1-8.5 years) following surgery. Results: The final follow-up visit showed satisfactory outcomes, with VAS score reducing from the preoperative 8 (7-9) to postoperative 2 (0-4), whereas the AOFAS score improved from the preoperative 29 (20-44) to the postoperative 79 (70-88). The patient’s subjective ratings showed excellent results in 4 feet, good results in 8 feet, and fair outcomes in 2 feet. The hindfoot range of motion remained unchanged, as did the extent of the navicular complex arthritis, and no patient required an arthrodesis since surgery. Conclusion: A calcaneal osteotomy can be used as an alternative treatment option for selected MWD patients regardless of the radiologic stage of the disease. Level of Evidence: Level IV, retrospective case series.