bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study Protocol Transvaginal Natural Orifice Transluminal Endoscopic Surgery for Tubal Ectopic Pregnancy(vNOTESTEP): a Protocol for a Randomized Controlled Trial
Authors: Xiao Xinyu , Liu Tianjiao , Li Xin , He Li , Lin Yonghong , Feng Dan 
Published: September 2024

Abstract

Background
Tubal ectopic pregnancy poses a severe threat to the life of women in early pregnancy. There is an increasing tendency to use minimally invasive laparoscopic surgery to treat tubal ectopic pregnancies. Many retrospective studies have shown that Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) has a lower rate of perioperative complications, faster postoperative recovery, and better cosmetic outcomes when treating tubal ectopic pregnancy. However, the lack of unbiased, detailed perioperative and long-term postoperative data to support the feasibility and safety of vNOTES remains contentious and may impede its acceptance in gynecology.
Methods
The vNOTESTEP study is a randomized controlled trial (RCT) that will recruit about 72 gynecologic patients with indications of laparoendoscopy for treating tubal ectopic pregnancy. Patients will be randomly divided into the vNOTES or transumbilical laparoendoscopic single-site (TU-LESS) group and undergo corresponding approach. After obtaining the participants’ consent, a perioperative assessment and a 5-year postoperative follow-up with eight visits will be conducted. Data collection will be performed perioperatively and postoperatively at designated time points, e.g., 1st, 2nd, and 3rd postoperative day; 1st, 3rd, and 6th month; and 1st, 2nd, 3rd, 4th, and 5th year after the surgery. The baseline information collection will include subjects’ sociodemographics and their health- and gestation-related history obtained from the Hospital Information System and face-to-face interviews. As planned, perioperative and postoperative outcomes will be examined based on intraoperative assessment, in-patient clinical observation, and follow-up WeChat questionnaires or clinic services. Among these outcomes, long-term postoperative results, such as sexual function, pregnancy, vaginal delivery, and incisional hernia, will be the focus.
Discussion
The vNOTESTEP study aims to assess the perioperative and long-term postoperative outcomes of vNOTES in the treatment of tubal ectopic pregnancy compared to TU-LESS, using a RCT design and focusing on patients’ sexual function, pregnancy, vaginal delivery, and incisional hernia. This two-arm, prospective vNOTESTEP study, incorporating a comprehensive long-term follow-up items, has the potential to furnish substantial and robust clinical evidence for refining and establishing guidelines for gynecologic vNOTES procedures. This initiative is also expected to enhance patients' perceptions and acceptance of this innovative minimally invasive surgical approach.
Trial registration number:
ChiCTR2400082909(registered on April 10th, 2024)
Mobile phone applications for midwives with focus on antenatal care: A mapping and assessment of quality and suitability for low-resource settings.
Authors: Panman Amalie , Sakalidis Vanessa S. , Bohle Leah F. 
Published: September 2024

Abstract

Background
Reducing maternal mortality in low-resource settings remains a priority in achieving the Sustainable Development Goal 3. The provision of antenatal care is an essential pillar in maternal health care. Digital health applications, which target midwives providing antenatal care, can assist workers in low-resource settings by providing access to quality tools and education for evidence-based care. This study aimed to identify mobile apps for midwives focusing on antenatal care and assessed their quality and suitability for use in low-resource settings.
Methods
A systematic mapping of mobile apps accessible on Google Play Store was performed using pre-defined search terms related to midwifery and antenatal care. Inclusion criteria based on numbers of downloads, English language, free of cost, and thematic focus, resulted in 15 apps for evaluation. The quality of apps and suitability for use in low-resource settings was assessed using two frameworks. An individual score was calculated for each app and a ranking was performed.
Results
Of the 15 apps identified, the focus was on educational content (n = 10), antenatal care measurement tools (n = 4), and patient documentation (n = 1). The quality of apps overall ranged between 1.77–4.80 points, with a maximum of 5 points. Suitability for low-resource settings was favourable in that the majority of the apps were available offline (n = 11), however, only some offered additional languages (n = 5), and few integrated cultural diversity and sensitivity (n = 2). All apps integrated at least one of WHO’s recommendations for a positive pregnancy, suggesting the apps were somewhat suitable for midwives delivering antenatal care; although no apps referenced WHO or referred to national clinical guidelines.
Conclusions
Significant gaps in the availability of apps targeting midwives represented a missed opportunity in the digital health landscape. Only two apps holistically implemented WHO antenatal care recommendations, and were rated high quality. No apps combined educational content and tools; or connected the midwife and pregnant woman. This review demonstrated that while there are several comprehensive apps targeting midwives, the minority of these are focusing on antennal care in low-resource settings and would benefit from further resources, development and regulation.
Correlation of Angle Kappa and Angle Alpha on Visual Outcomes in Eyes Implanted with Three Types of Diffractive Trifocal Intraocular Lenses
Authors: Ang Robert Edward T. , Doroy Zoe Alethinos M. , Yao Justin Alan A. , Cruz Emerson M. 
Published: September 2024

Abstract

Purpose: To evaluate the correlation between preoperative, postoperative, and change in angle kappa and alpha to visual outcomes following implantation of three diffractive trifocal intraocular lenses.
Methods: This is a retrospective study which included 122 eyes of 61 patients. There were 38 eyes in the Synergy (Johnson & Johnson, USA) group and 42 eyes each from both the Panoptix (Alcon Laboratories, USA) and FineVision (Physiol BVI, Belgium) groups. Visual outcome parameters (uncorrected distance, intermediate, near vision, halo and starburst) and angle kappa and alpha were recorded preoperatively and at three months postoperatively. The preoperative, postoperative and the amount of change in angle kappa and alpha were correlated to visual outcomes and photic phenomena among the three different diffractive trifocal IOLs.
Results: There were no significant differences in the preoperative and postoperative magnitude of angle kappa and alpha among the Synergy, Panoptix, and FineVision groups. There was no significant correlation between the preoperative and postoperative magnitude, and change in angle kappa and alpha with the postoperative uncorrected distance, intermediate and near visual acuity, and halo and starburst scores of the three different diffractive IOLs.
Conclusion: The frequency of eyes with greater than 0.5 mm angle kappa and alpha values were low. Visual outcomes can be good even in eyes in which the angle kappa and alpha were greater than 0.5 mm. The newer diffractive trifocal IOLs were observed to be more tolerant to low and intermediate levels of angle kappa and alpha.
Effects of different anesthesia methods on post-stroke dysphagia in a mouse model
Authors: Rao Tong , Rao Zhehua , Tian Cong , Lu Meng , Liu Xin , Cheng Ankun , Murong Zhimiao , Zhang You , Liu Qiuyao , Yue Zenghui 
Published: September 2024

Abstract

Photochemical embolization is an emerging method for establishing post-stroke dysphagia models. The use of different anesthetics is a key factor affecting the outcome of ischemic stroke modeling. This study compared the effects of three different anesthetics on the outcomes of mice with dysphagia modeled by photochemical embolization. Sixty-six male C57BL/6J mice were divided into four groups consisting of tribromoethanol, isoflurane, pentobarbital sodium and control. The cerebral blood flow and wake-up time were recorded before and after modeling. Mortality, cerebral blood flow, neurological deficit score, infarct volume, water intake, swallowing counts, and swallowing EMG area were assessed 48 hours later. The results of the study showed that 48 hours after modeling, mice in the three groups all developed localized cerebral infarction and dysphagia. The mice in the isoflurane group had a different decreasing trend in cerebral blood flow within 48 hours after modeling. These mice needed less time to wake up and had lower mortality compared with those in the other model groups. These findings provided suggestions and evidence for the future selection of anesthesia for PSD model preparation using the PT method.
Sedimentary Petrology and Basin Analysis of the Mamu Formation: Insights into Provenance, Depositional Environments, and Paleohydrodynamic Conditions
Authors: Agbo Christian , Onyekuru Samuel , Ikoro Diugo 
Published: September 2024

Abstract

The Mamu Formation, a sedimentary unit of significant geological and economic interest, remains incompletely understood. This study employed sedimentary petrology and basin analysis techniques to investigate the provenance, depositional environments, and paleohydrodynamic conditions associated with the formation. Sediment samples (MA.1 through MA.8) were collected from various stratigraphic levels to capture the lithological variations within the Mamu Formation. A three-step methodology was implemented. First, samples underwent standard preparation techniques (washing, sieving, drying, crushing, homogenization). Second, petrographic analysis involved creating thin sections from each sample for examination under a polarizing microscope. Modal composition (quartz, feldspar, rock fragments) was quantified using the point-counting method. Finally, a ternary diagram was utilized to visualize the compositional data and classify the sandstones based on their detrital grain composition (quartz, feldspar, rock fragments). The dominance of quartz suggests a likely igneous or metamorphic source area, while the presence of feldspar and rock fragments indicates a potentially mixed source and relatively short transport distances. Grain size distribution points towards a high-energy environment like a fluvial or beach setting. Poor sorting and variable skewness values suggest fluctuations in flow strength during deposition. This analysis provides valuable insights into the origin, transport, and depositional history of the Mamu Formation sediments.
Developing a Cognitive Profile for Early Detection of Cognitive Decline: Identifying Key Risk Factors and Target Populations
Authors: Gil-Peinado María , Muñoz-Almaraz Francisco Javier , Ramos Hernán , Sendra-Lillo José , Moreno Lucrecia 
Published: September 2024

Abstract

Purpose: Early screening for cognitive decline (CD) is crucial for managing dementia risk factors and preventing disease progression. This study seeks to create a detailed cognitive profile for patients who are candidates for CD screening, with a focus on identifying emerging cognitive deficits and their underlying causes.
Methods: We first performed a systematic review of CD screening practices within community pharmacies. Following this, we analyzed data from 286 individuals who were screened after the introduction of these practices across 18 community pharmacies. This analysis aimed to pinpoint factors influencing patients who report subjective memory complaints (SMC).
Results: Our findings reveal that CD screening is not widely promoted globally, and participation among pharmacies remains limited. We identified specific characteristics associated with a higher risk of subjective cognitive decline (SCD), including age, usage of internet and social media, sleep patterns, and educational attainment. These factors are essential for defining the profile of individuals who would benefit most from CD screening services.
Conclusion: Enhancing early dementia detection in primary care settings may be achieved by focusing on individuals with limited engagement with internet and social media, irregular sleep patterns, and lower levels of education. Targeting these groups could significantly improve the effectiveness of CD screening programs.
Computational task transfer scheme based on multi-agent generative adversarial imitation learning
Authors: Huang Haojing , Li Jiajun , Lu Fei , Li Jianxin 
Published: September 2024

Abstract

The multi-agent computing task scheduling problem can be transformed into a task assignment optimization problem under the premise of minimum system cost and maximum sample utilization. For this problem, this paper proposes a computational task migration scheme based on multi-agent body generation adversarial imitation learning. In the battlefield, this scheme uses the idle computing power of tanks, fighting vehicles, drones or infantry equipment to form a Ad Hoc cloud. Based on the characteristics of distributed training of reinforcement learning algorithm, it makes full use of equipment resources to solve the transfer scheme of computing tasks. By using behavioral cloning to construct the data set and build the initial strategy model, the reward function is simplified, and the network structure, parameters and training hyperparameters are set. Driven by the training set, the generative adversarial inverse reinforcement learning method is used for network training. The simulation results show that the MAGAIL-MCT algorithm can mimic the expert trajectory behavior and successfully train the neural network. The experimental results prove that the scheme is improved in reducing system overhead, improving sample utilization, reducing migration delay, migration energy consumption and reducing the impact of mobility.
Long-term complications of Shiga toxin-producing Escherichia coli O157 (STEC O157) infection and STEC-associated haemolytic uraemic syndrome (STEC-HUS), Wales, 1990-2020
Authors: Merrick Rachel , Song Jiao , Fina Laia , Sawyer Clare , Jenkins Claire , King Grace , Turner Drew , Thomas Daniel , Williams Christopher 
Published: September 2024

Abstract

Background Information on sequelae of Shiga toxin-producing Escherichia coli (STEC) O157 infection is limited to short-term follow-up of paediatric haemolytic uraemic syndrome (HUS) cases. We investigate recorded long-term health outcomes experienced by individuals exposed to STEC O157 and STEC-HUS up to three decades on.Methods We compared acute or new onset of chronic outcomes in individuals ≥ 1 year after STEC O157 or STEC-HUS to unexposed general population comparators between 01/01/1990-01/01/2019. The unexposed were their age- and sex-equivalents (4:1 matching ratio) and assigned the same study entry date. Outcomes were identified in primary and secondary care and categorised as renal, neurological, cardiac, gastrointestinal, respiratory, or endocrine. Hazard ratios (HRs) and 95% confidence intervals (95%CI) were calculated using Cox regression.Results Of 1,245 individuals with STEC O157, 65 developed HUS (5.2%). Individuals with STEC O157 were more likely to experience renal (adjusted (a)HR: 1.9, 95%CI: 1.1–3.3), gastrointestinal (aHR: 1.7, 95%CI: 1.2–2.6) and respiratory (aHR: 1.3, 95%CI: 1.2–1.5) outcomes compared to the unexposed, on average between 3.4–11 years after exposure. Gastrointestinal (HR: 7.7, 95%CI: 2.6–23), renal (HR: 5.5, 95%CI: 1.6–19), cardiac (HR: 5.1, 95%CI: 1.1–23) and respiratory (HR: 1.9, 95%CI: 1.1–3.1) outcomes were more common in the STEC-HUS cohort and occurred sooner, on average after 2.7–4.8 years.Conclusions Long-term complications were nearly twice as likely in the STEC O157 cohort, and as many as eight times more likely following STEC-HUS. We recommend that those exposed to STEC be monitored for at least five years for late-emerging renal and extrarenal complications.
Prevalence of acute jaundice syndrome (AJS) in Rajshahi, Bangladesh: A sociodemographic and clinical manifestation
Authors: Mubassira Mahi , Muhib Md. Muntasir Alam , Abeed-Ul-Haque Syed , Khanam Sanzida , Hasan Md. Faruk 
Published: September 2024

Abstract

Background
The present study was designed to determine the outbreak pattern, diagnosis and treatment of jaundice patients at Rajshahi, Bangladesh.
Methods
A total of 1151 students living near the University of Rajshahi were included in the sample. Jaundice syndromes were determined by physiological and laboratory tests. Blood and urine were tested to confirm the pathophysiology by an automated clinical chemistry analyzer.
Results
Among the total number of tested patients, 27.28% and 72.72% had jaundice-positivity and negativity, respectively. Jaundice-positive patients had the highest average alanine transaminase (ALT) level (1312.67 ± 1.32 U/L), and the total bilirubin level was 2.08 ± 0.70 mg/dL for adults.
Conclusion
The present study provides vital information about the patterns of jaundice outbreaks, prompt diagnosis and effective control measures to protect students' health and the whole community.
Functional Insights into Novel Extremophilic Bacteria Isolated from the NASA Phoenix Mission Spacecraft Assembly Cleanrooms
Authors: Schultz Júnia , Jamil Tahira , Sengupta Pratyay , Sivabalan Shobhan Karthick Muthamilselvi , Rawat Anamika , Patel Niketan , Krishnamurthy Srinivasan , Alam Intikhab , Singh Nitin Kumar , Raman Karthik , Rosado Alexandre Soares , Venkateswaran Kasthuri 
Published: September 2024

Abstract

Human-designed oligotrophic environments, such as cleanrooms, harbor unique microbial communities shaped by selective pressures like temperature, humidity, nutrient availability, cleaning reagents, and radiation. During the Phoenix spacecraft mission, genomes of 215 bacterial isolates were sequenced and based on overall genome related indices, 53 strains belong to 26 novel species were recognized. Metagenome mapping indicated less than 0.1% of the reads associated with novel species, suggesting their rarity. Genes responsible for biofilm formation, such as BolA (COG0271) and CvpA (COG1286), were predominantly found in proteobacterial members but were absent in other non-spore-forming and spore-forming species. YqgA (COG1811) was detected in most spore-forming members but was absent in Paenibacillus and non-spore-forming species. Cell fate regulators, COG1774 (YaaT), COG3679 (YlbF, YheA/YmcA), and COG4550 (YmcA, YheA/YmcA), controlling sporulation, competence, and biofilm development processes, were observed in all spore-formers but were missing in non-spore-forming species. COG analyses further revealed resistance-conferring proteins in all spore-forming novel species (n=13) and eight actinobacteria, responsible for enhanced membrane transport and signaling under radiation (COG3253), transcription regulation under radiation stress (COG1108), and DNA repair and stress responses (COG2318). Additional functional analysis revealed that Agrococcus phoenicis, Microbacterium canaveralium, and Microbacterium jpeli contained biosynthetic gene clusters (BGCs) for ε-Poly-L-lysine, beneficial in food preservation and biomedical applications. Two novel Sphingomonas species exhibited zeaxanthin, an antioxidant beneficial for eye health. Paenibacillus canaveralius harbored genes for bacillibactin, crucial for iron acquisition. Georgenia phoenicis had BGCs for alkylresorcinols, compounds with antimicrobial and anticancer properties used in food preservation and pharmaceuticals. Despite strict decontamination and controlled environmental conditions, cleanrooms foster novel bacterial species which can form biofilms, resist various stressors, and produce biotechnologically valuable compounds.
Covid-19 Vaccine Acceptance, Hesitancy and Refusal Among Workers in a Paris Hospital Group
Authors: SAVIN Priscilla , CLIN Bénédicte 
Published: September 2024

Abstract

Background
The aim of this study was to analyse the determinants of COVID-19 vaccination and booster dose acceptance and underlying reasons for hesitancy or refusal, among workers of a Paris hospital group.
Methods
This prospective questionnaire study included 845 hospital workers who completed a questionnaire between 16 November 2021 and 10 January 2022.
Results
The main reasons for vaccine hesitancy were insufficient hindsight on the vaccine, lack of information, and fear of side effects. 48.8% of respondents did not feel vaccine hesitant, whereas 34.8% felt little hesitancy, and 16.4% felt significant hesitancy. 35.9% of auxiliary nurses felt strong vaccine hesitancy compared to 3.8% of medical practitioners (p < 0.001). Acceptance of the vaccine booster dose was 78.0%. The main reasons for vaccination were personal conviction (61.7%), mandatory vaccination (38.6%) and sanitary pass implementation (23.8%). The main reasons for hesitancy were lack of data (40.1%) followed by fear of side effects (29.3%). In 78 of the 105 employees who refused the vaccine booster dose, the reasons were the same as those for initial vaccination.
Conclusion
The employees expressing the highest COVID-19 vaccine hesitancy were women, hospital housekeepers, nurses and the 20–29 year age group. We must therefore focus our reinsurance and information efforts on these populations with greater vaccine hesitancy.
Evaluation of caesarean rates according to Robson classification using a newly developed smart phone application in a tertiary centre in Sri Lanka: Comparative study
Authors: Jayasundara Chandana , Piyadigama Indunil , Jayawardane Asanka , Perera Ananda 
Published: September 2024

Abstract

Objective
Caesarean section (CS) rates are increasing in Sri Lanka. More than half of births will occur through CS by 2025. CS should be medically indicated to reduce maternal morbidity. Robson classification is useful in assessing the indications for CS. It is difficult to obtain high-quality prospective data using traditional data collection methods. We intend to assess the use of new technology for this purpose.
Methods
We used the RobsApp® which is a newly developed smart phone application from April to October 2019 at the professorial unit De Soysa Hospital for Women (DSHW) for prospective data collection and analysis of 1712 deliveries according to Robson classification. This data is compared with Robson standards and previous traditional data collection methods.
Results
The quality of data gathered matched the recommendations by Robson guidance. The overall CS rate was 33.0%. The majority of the CS were carried out for Robson category 5a. Breech presentation accounted for 11.6% of CSs. Emergency CS contributed to 49.6% with CTG abnormalities being the most frequent indication.
Conclusions
RobsApp® is a convenient method for prospective data collection which allows achievement of the data quality recommended by the Robson guidance. The CS rates are rising in professorial unit DSHW. Increasingly CS are being performed for reasons other than for past sections.