bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and application of selective adsorbent for pirimicarb pesticides in aqueous media using allyl‐β‐cyclodextrin based binary functional monomers
Authors: He Chengzijing , Lay Sovichea , Yu Haining , Shen Shengrong 
Published: September 2017

AbstractBACKGROUNDBinary functional monomers, allyl‐β‐cyclodextrin (allyl‐β‐CD) and methacrylic acid (MAA) or allyl‐β‐CD and acrylonitrile (AN), were exploited in a fabrication of molecularly imprinted polymers (MIPs) for selective recognition and large enrichment of pirimicarb from aqueous media.RESULTSSpecial attention was paid to the computational simulation of the imprinting molecular and functional monomers. The morphological characteristics of MIPs made of allyl‐β‐CD and MAA (M‐MAA) were characterised by scanning electron microscopy. The effect of binding capacity of MAA‐linked allyl‐β‐CD MIPs (M‐MAA) demonstrated higher efficiency than that of AN‐linked allyl‐β‐CD MIPs (M‐AN) when tested in binding specificity. Finally, M‐MAA was chosen to run through molecularly imprinted solid‐phase extraction (MISPE) to analyse the spiked fresh leafy vegetables of pirimicarb.CONCLUSIONThe present proposed technique is a promising tool for the preparation of the receptors which could recognise pirimicarb pesticide in aqueous media. © 2017 Society of Chemical Industry
The PD‐1 and PD‐L1 pathway in recurrent respiratory papillomatosis
Authors: Ahn Julie , Bishop Justin A. , Roden Richard B. S. , Allen Clint T. , Best Simon R. A. 
Published: September 2017

Objectives/HypothesisGeneration of an immunosuppressive microenvironment may enable a persistent human papillomavirus infection in the setting of an otherwise normal immune system. We hypothesized that expression of the T‐lymphocyte co‐inhibitory receptor programmed death 1 (PD‐1) and its ligand PD‐L1 would be increased in the recurrent respiratory papillomatosis (RRP) microenvironment compared to normal controls.Study DesignCase‐control study.MethodsFormalin‐fixed paraffin‐embedded respiratory papilloma and normal controls were obtained under institutional review board approval, stained for CD4, CD8, FoxP3, and PD‐1, and scored by automated cell count. PD‐L1 staining was scored by a blinded pathologist using an adjusted inflammation score that accounted for epithelial and immune infiltrate.ResultsThirty‐nine RRP cases and seven controls were studied. All immunologic markers demonstrated significantly increased staining in RRP specimens compared to normal controls (all P < .01). PD‐1 correlated with both CD4 (P < .0001) and CD8 (P < .001) cell counts. Epithelial staining for PD‐L1 (68%) and PD‐L1+ infiltrating immune cells (76%) were observed in the majority of papilloma samples. The strongest staining for PD‐L1 was usually observed in the basal papilloma layer adjacent to the immunologic infiltrate in the vascular core. Disease severity inversely correlated with CD8 cell counts (P = .01). A correlation between disease severity and other immunologic markers was not observed.ConclusionsMost RRP specimens demonstrate PD‐1 T‐lymphocyte infiltration and PD‐L1 expression on both papilloma and infiltrating immune cells. This study suggests that this checkpoint pathway may be contributing to local immunosuppression in RRP, and opens the door for clinical trials utilizing PD‐blocking monoclonal antibodies.Level of EvidenceNA Laryngoscope, 128:E27–E32, 2018
Assessment of a photon‐counting detector for a dual‐energy C‐arm angiographic system
Authors: Ahmad Moiz , Fahrig Rebecca , Pung Leland , Spahn Martin , Köster Niko S. , Reitz Silke , Moore Teri , Choi Jang‐Hwan , Hinshaw Waldo , Xia Yan , Müller Kerstin 
Published: September 2017

PurposeThis article presents the implementation and assessment of photon‐counting dual‐energy x‐ray detector technology for angiographic C‐arm systems in interventional radiology.MethodsA photon‐counting detector was successfully integrated into a clinical C‐arm CT system. Detector performance was assessed using image uniformity metrics in both 2D projections and 3D cone‐beam computed tomography (CBCT) images. Uniform exposure fields were acquired to analyze projection images and scans of a homogeneous cylinder phantom were taken to analyze 3D reconstructions. Image uniformity was assessed over a broad range of imaging parameters.ResultsDetector calibration greatly improved image uniformity, reducing image variation from 8.8% to 0.5% in an ideal scenario, but image uniformity degraded when imaging parameters varied strongly from values set at calibration: the tube voltage, low‐high energy threshhold, and tube current had the greatest impact. Material discrimination and dynamic angiography capabilities were successfully demonstrated in separate phantom and in vivo experiments.ConclusionThe uniformity results identified major factors degrading image quality. The quantitative results will guide selection of calibration points to mitigate the loss of uniformity. The unique combination of dual‐energy and fluoroscopy imaging capabilities with a flat‐panel photon‐counting detector may enable new applications in interventional radiology.
Technical Note: Scanning of parallel‐plate ionization chamber and diamond detector for measurements of water‐dose profiles in the vicinity of a narrow x‐ray microbeam
Authors: Nariyama Nobuteru 
Published: September 2017

PurposeScanning of dosimeters facilitates dose distribution measurements with fine spatial resolutions. This paper presents a method of conversion of the scanning results to water‐dose profiles and provides an experimental verification.MethodsAn Advanced Markus chamber and a diamond detector were scanned at a resolution of 6 μm near the beam edges during irradiation with a 25‐μm‐wide white narrow x‐ray beam from a synchrotron radiation source. For comparison, GafChromic films HD‐810 and HD‐V2 were also irradiated. The conversion procedure for the water dose values was simulated with Monte Carlo photon‐electron transport code as a function of the x‐ray incidence position. This method was deduced from nonstandard beam reference‐dosimetry protocols used for high‐energy x‐rays.ResultsAmong the calculated nonstandard beam correction factors, Pwall, which is the ratio of the absorbed dose in the sensitive volume of the chamber with water wall to that with a polymethyl methacrylate wall, was found to be the most influential correction factor in most conditions. The total correction factor ranged from 1.7 to 2.7 for the Advanced Markus chamber and from 1.15 to 1.86 for the diamond detector as a function of the x‐ray incidence position. The water dose values obtained with the Advanced Markus chamber and the HD‐810 film were in agreement in the vicinity of the beam, within 35% and 18% for the upper and lower sides of the beam respectively. The beam width obtained from the diamond detector was greater, and the doses out of the beam were smaller than the doses of the others.ConclusionsThe comparison between the Advanced Markus chamber and HD‐810 revealed that the dose obtained with the scanned chamber could be converted to the water dose around the beam by applying nonstandard beam reference‐dosimetry protocols.
A novel approach to probing in vivo metabolite relaxation: Linear quantification of spatially modulated magnetization
Authors: Li Linqing , Li Ningzhi , An Li , Shen Jun 
Published: September 2017

PurposeConventional sequences for metabolite transverse relaxation quantification all generally measure signal changes at different echo times (TEs). However, quantification results obtained via these conventional methods can be very different and are highly dependent on the type of sequence being applied. TE‐dependent effects such as diffusion, macromolecule baseline, and J‐coupling modulation contribute significantly to these differences. Here, we propose a novel technique—multiple flip angle pulse‐driven ratio of longitudinal steady states (MARzss)—for preparing magnetization with T2/T1 weighting. Using premeasured T1 values, T2 values for metabolites can thereby be determined. The measurement procedure does not require varying TE and is TE independent; T2, diffusion, and J‐coupling effects induced by the readout sequence are cancelled.MethodLongitudinal steady states at different flip angles were prepared with trains of radio frequency pulses interspersed with field gradients. The resulting spatially modulated longitudinal magnetization was acquired with a PRESS readout module. A new linear equation for quantification of MARzss was derived from Bloch equations.ResultsBy implementing this readout‐independent method, T2 measurement of brain metabolites at 7T was demonstrated through Bloch simulations, phantom, and in vivo experiments.ConclusionsThe proposed MARzss technique can be used to largely avoid multi‐TE associated interference, including diffusion, macromolecules, and J modulation. This MARzss technology, which is uniquely insensitive to readout sequence type and TE, is a promising technique for more accurately probing in vivo metabolite relaxation. Magn Reson Med 79:2491–2499, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Chronic psychological stress promotes lung metastatic colonization of circulating breast cancer cells by decorating a pre‐metastatic niche through activating β‐adrenergic signaling
Authors: Chen Hongyu , Liu Dan , Guo Liang , Cheng Xiang , Guo Ning , Shi Ming 
Published: September 2017

AbstractNumerous studies have indicated that primary tumors induce the formation of a pre‐metastatic niche in distant organs by secreting tumor‐derived factors. The present study shows that pre‐exposure to chronic stress enhanced lung colonization efficiency by circulating tumor cells, suggesting that chronic stress critically influences pre‐metastatic lungs before the arrival of disseminated tumor cells. Ablation of the sympathetic nerve function by 6‐OHDA or blockage of the β‐adrenergic signaling by propranolol remarkably suppressed stress‐induced lung metastasis. Depletion of circulating monocytes or lung macrophages strongly abolished stress‐induced lung seeding by tumor cells, whereas treatment of mice with the β‐adrenergic agonist isoproterenol (ISO) during the pre‐metastatic phase promoted the infiltration of macrophages to the lung. Meanwhile, the numbers of monocytes in peripheral blood, spleen, and bone marrow were remarkably increased in response to ISO stimulation. These data indicate that the β‐adrenergic signaling promotes lung metastatic colonization by tumor cells through increased output of monocytes in the pre‐metastatic phase and infiltration of macrophages into the pre‐metastatic lung. Mechanistic studies revealed that ISO stimulation upregulated the expression of CCL2 in pulmonary stromal cells and CCR2 in monocytes/macrophages, leading to the recruitment and infiltration of macrophages into the pre‐metastatic lung. By inducing a response of monocytes/macrophages driven by the CCL2/CCR2 axis, stress‐related catecholamine may act as a crucial factor in regulating the pre‐metastatic niche for and lung colonization by tumor cells. Our data demonstrate that disturbance of host macro‐environmental homeostasis has an influence on future metastatic organs. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Novel HPPD inhibitors: triketone 2H‐benzo[b][1,4]oxazin‐3(4H)‐one analogs
Authors: Li Hua‐Bin , Li Lei , Li Jun‐Xian , Han Ting‐Feng , He Jing‐Li , Zhu You‐Quan 
Published: September 2017

AbstractBACKGROUNDHerbicides that inhibit 4‐hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) are very important for grass weed control. In order to discover novel HPPD herbicides, a series of triketone 2H‐benzo[b] oxazin‐3(4H)‐one analogs was designed and synthesized.RESULTSIn comparison with the commercial triketone HPPD herbicide mesotrione (IC50 = 0.252 μM), some of these new triketone analogs displayed excellent HPPD inhibitory potency in vitro, for example B39 (IC50 = 0.172 μM) and B41 (IC50 = 0.156 μM). In addition, some of these compounds exhibited pre‐ and post‐emergence herbicidal activity similar to mesotrione when applied at 375 g/ha.CONCLUSIONMany of the title compounds described in this paper could be important lead structures for the further development of novel HPPD herbicides. © 2017 Society of Chemical Industry
Peptide‐Conjugated Nano‐Drug Delivery System to Improve Synergistic Molecular Chemotherapy for Colon Carcinoma
Authors: Rayappan Kathirvel , Murugan Chandran , Sundarraj Shenbagamoorthy , Lara Roberto Portillo , Kannan Soundarapandian 
Published: September 2017

AbstractThe biofunctional significance of hollow mesoporous silica nanoparticles (HMSNs) could be used as nano‐reservoirs. Here in the β‐sitosterol loaded into the hollow core and the cisplatin substituted with the carboxylic group of poly lactic acid (PLA)‐ polyethylene glycol (PEG) on the pore walls of HMSNs. Subsequently, the tumour biomarker somatostatin peptide (3207‐86) conjugated to Methyl polyethylene glycol 2‐maleimide ethyl ether (Meo‐PEG‐Mal) for the selective targeting of tumour cells. The surface modified HMSNs enable the internalization of cisplatin via chlorine ion release, through the cleavage of the coordinated interaction. Further, the β sitosterol release is dependent on the discharge rate of cisplatin and the pH of the cell microenvironment. The engineered nano‐drug delivery system could be used to selectively target cancer cells and deliver multimodal therapeutic schemes for the treatment of colon cancer
Synthesis of 1,128‐Octacosahectanediol and Its Sharp Thermoresponse in Solution with Concomitant Structural Change
Authors: Saito Nozomi , Shinozaki Yasuhiro , Shigeno Masanori , Mushiake Kumiko , Yamaguchi Masahiko 
Published: September 2017

Abstract1,128‐Octacosahectanediol, which has an extremely long polymethylene chain, was synthesized. The heptaene C128 intermediate with both ends silylated was synthesized by the sequence of the Wittig reaction and acetal deprotection in a two‐directional manner. The unsaturated compound was converted to a saturated disilyl ether by homogeneous hydrogenation under toluene reflux, and was subsequently desilylated under THF/toluene/12 M HCl refluxing conditions to yield a C128 diol. High‐temperature conditions were employed to dissolve the substrates, and cooling liberated the products, which were isolated by filtration. 1,128‐Octacosahectanediol showed a sharp increase in solubility in organic solvents with temperature changes of 10 K along with thermal hysteresis, which was ascribed to the concomitant structural change. The extended structure in the solid state was converted to a globular structure in solution, which involved large enthalpic loss and entropic gain.
Direct Synthesis of Sulphonates of Alcohol, Oxyma‐O‐sulphonates and Oxime‐O‐sulphonates under Microwave Irradiation
Authors: Chandra Jyoti , Chaudhuri Rohit , Manne Srinivasa Rao , Mondal Sandip , Mandal Bhubaneswar 
Published: September 2017

AbstractWe describe a new halogen and metal free microwave assisted industrially feasible environment friendly method for the synthesis of sulphonate esters from substituted benzene sulphonic acids by direct condensation. This high yielding method has been applied to various primary and secondary alcohols and oximes especially Oxyma to attach with sulphonic acids. Reactions have completed within 5 min at 120 °C under microwave irradiation. This atom economic approach is green as only generated byproduct is water and it represents a substantial improvement over previously described methods for the purpose. Use of silica gel improved the yield for some substrates. Possibility of scale up of the reaction is demonstrated. Mechanistic investigation of silica aided reaction revealed two novel intermediates.
Manganese Dioxide Nanosheets‐Induced Oxidation of Dopamine for Colorimetric Sensing of Hydrogen Sulfide
Authors: He Yi , Cai Yanhua , Huang Wei 
Published: September 2017

AbstractHere we report a selective and highly sensitive colorimetric sensing system based on MnO2 nanosheets and dopamine for the detection of hydrogen sulfide (H2S). MnO2 nanosheets show a capability for direct oxidation of dopamine to aminochrome, producing a strong UV‐vis absorption at 470 nm and accompanying a distinct color change from colorless to orange. When H2S is present in the sensing system, it can effectively inhibit the redox reaction between MnO2 nanosheets and dopamine. In this case, the concentration of the aminochrome in the reaction solution significantly decreases, and the color of the solution gradually fades with the increasing of the concentration of H2S. The solution turns colorless when the concentration of H2S exceeds 75 μM. The dynamic range of the calibration curve is 0.2‐125 μM, and the limit of detection is estimated to be 0.08 μM at a signal‐to‐noise ratio of 3:1.
Heterologous expression of a β-d-glucosidase in Caldicellulosiruptor bescii has a surprisingly modest effect on the activity of the exoproteome and growth on crystalline cellulose
Authors: Kim Sun-Ki , Chung Daehwan , Himmel Michael E , Bomble Yannick J , Westpheling Janet 
Published: September 2017

Abstract
Members of the genus Caldicellulosiruptor are the most thermophilic cellulolytic bacteria so far described and are capable of efficiently utilizing complex lignocellulosic biomass without conventional pretreatment. Previous studies have shown that accumulation of high concentrations of cellobiose and, to a lesser extent, cellotriose, inhibits cellulase activity both in vivo and in vitro and high concentrations of cellobiose are present in C. bescii fermentations after 90 h of incubation. For some cellulolytic microorganisms, β-d-glucosidase is essential for the efficient utilization of cellobiose as a carbon source and is an essential enzyme in commercial preparations for efficient deconstruction of plant biomass. In spite of its ability to grow efficiently on crystalline cellulose, no extracellular β-d-glucosidase or its GH1 catalytic domain could be identified in the C. bescii genome. To investigate whether the addition of a secreted β-d-glucosidase would improve growth and cellulose utilization by C. bescii, we cloned and expressed a thermostable β-d-glucosidase from Acidothermus cellulolyticus (Acel_0133) in C. bescii using the CelA signal sequence for protein export. The effect of this addition was modest, suggesting that β-d-glucosidase is not rate limiting for cellulose deconstruction and utilization by C. bescii.
Psychosocial Implications of Living with Catecholaminergic Polymorphic Ventricular Tachycardia in Adulthood
Authors: Richardson Ebony , Spinks Catherine , Davis Andrew , Turner Christian , Atherton John , McGaughran Julie , Semsarian Christopher , Ingles Jodie 
Published: September 2017

AbstractCatecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmogenic disease with a high risk of sudden cardiac death. The impact on health‐related quality of life (HR‐QoL) and psychosocial outcomes is not known. We sought to provide the first description of HR‐QoL and psychosocial wellbeing of adults with CPVT, parents of affected children and at‐risk relatives. Participants were recruited through the Australian Genetic Heart Disease Registry and invited to complete a cross‐sectional survey comprising a number of validated scales and open‐ended questions. Thirty‐five participants completed surveys (response rate 65%), including 19 with CPVT, 10 unaffected parents of a child with CPVT, and 7 at‐risk relatives (one participant considered patient and parent). Young patients <40 years were significantly more likely to report anxiety (p = 0.04), depression (p = 0.03) and posttraumatic stress symptoms (p = 0.02) compared to older CPVT patients. Further, young patients with an implantable cardioverter defibrillator (ICD) reported significantly worse device‐related distress (p = 0.04) and shock anxiety (p = 0.003). Patients with a genetic diagnosis had worse psychological adaptation than those patients without a gene result. Parents perceived their affected children to have poor quality of life across all subdomains compared to healthy age‐matched children, however quality of life of parents and at‐risk relatives was comparable to population norms. Ongoing psychosocial care is required for young people with CPVT. Those with an ICD and/or undergoing genetic testing may require additional support. The challenges of CPVT management should extend beyond the clinical and genetic aspects of care to incorporate greater psychosocial support, and further reinforces the need for a multidisciplinary approach to care.
Multifetal Pregnancy Reduction
Authors: Dadhwal Vatsla , Khoiwal Kavita 
Published: September 2017

AbstractMultifetal pregnancy increases maternal, fetal and neonatal complications, most important being preterm delivery and complications of prematurity. Fetal reduction is a procedure for reducing the number of fetuses to a more manageable number. Reduction of triplet or higher order pregnancy is acceptable and the ending number is usually two. Fetal reduction reduces the risk of preterm delivery. Intracardiac/intrathoracic KCl is used for fetal reduction in multichorionic pregnancy. This is not a viable option in monochorionic pregnancy, where vaso-occlusive methods are used.
The effects of self‐efficacy in bifurcating the relationship of perceived benefit and cost with condom use among adolescents: A cusp catastrophe modeling analysis
Authors: Xu Yunan , Chen Xinguang , Yu Bin , Joseph Verlin , Stanton Bonita 
Published: September 2017

ABSTRACTThis study tested the complex relationship among the perceived benefit from and cost of condom use, self‐efficacy and condom use among adolescents as a nonlinear dynamic process. Participants were 12th graders in public Bahamian high schools who reported having had sex and frequency of condom use. Results revealed that the perceived benefit and perceived cost as asymmetry variables were significantly associated with condom use (p < 0.001) after controlling for covariates. The association was bifurcated by the variable self‐efficacy (p < 0.001). Furthermore, the cusp model was better than linear and logistic regression models in predicting the dynamic changes in condom use behavior, judged by the AIC and BIC, and R2 criteria. These results suggest that adolescent condom use may follow a nonlinear rather than linear dynamic process. Emphasizing bifurcation variables such as self‐efficacy that promote sudden change could be essential to strengthen current evidence‐based intervention programs in encouraging condom use.