bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reciprocal Negative Regulation between EGFR and DEPTOR Plays an Important Role in the Progression of Lung Adenocarcinoma
Authors: Zhou Xuefeng , Guo Jialong , Ji Yanmei , Pan Gaofeng , Liu Tao , Zhu Hua , Zhao Jinping 
Published: February 2016

Abstract
The epidermal growth factor receptor (EGFR) activates downstream mTOR phosphorylation to promote the progression of many different tumor types, thus making it a prime therapeutic target. However, the role of DEP domain-containing mTOR-interacting protein (DEPTOR), a natural mTOR inhibitor, remains unclear in this process. Here, it is reported that EGFR expression is significantly increased in tumors of lung adenocarcinoma patients and is negatively correlated with the expression of DEPTOR. Activation of EGFR signaling, by EGF, in A549 lung adenocarcinoma cells (overexpressing EGFR) significantly enhanced the function of the mTOR autoamplification loop, consisting of S6K, mTOR, CK1α, and βTrCP1, which resulted in downregulation of DEPTOR expression. Gefitinib, a specific EGFR inhibitor, stimulated DEPTOR accumulation by downregulating the function of the mTOR autoamplification loop. Furthermore, a series of assays conducted in DEPTOR knockout or ectopic expression in A549 cells confirmed that DEPTOR inhibited proliferation, migration, and invasion as well as the in vivo tumor growth of lung adenocarcinoma. Importantly, tumor progression mediated by EGFR ectopic expression was diminished by transfection with DEPTOR. This study uncovers the important inhibitory role of DEPTOR in lung adenocarcinoma progression and reveals a novel mechanism that EGFR downregulates DEPTOR expression to facilitate tumor growth.
Implications: DEPTOR acts as a tumor suppressor by limiting EGFR-driven lung adenocarcinoma progression. Mol Cancer Res; 14(5); 448–57. ©2016 AACR.
Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Predicts Future Risk of Cardiovascular Events Independently of Established Risk Factors
Authors: Leander Karin , Mälarstig Anders , van’t Hooft Ferdinand M. , Hyde Craig , Hellénius Mai-Lis , Troutt Jason S. , Konrad Robert J. , Öhrvik John , Hamsten Anders , de Faire Ulf 
Published: February 2016

Background—
The secreted protein proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising new target for lowering plasma low-density lipoprotein cholesterol and preventing cardiovascular disease (CVD). The relationship between circulating PCSK9 and incident CVD in the general population is unknown. We investigated whether serum PCSK9 concentration is associated with incident CVD in a prospective cohort study of 4232 men and women 60 years of age at the time of recruitment.

Methods and Results—
Incident CVD was recorded by matching to national registries. After 15 years of follow-up, a total of 491 incident events (fatal and nonfatal myocardial infarctions, unstable angina, deaths from coronary heart disease, fatal and nonfatal ischemic strokes) were recorded. Cox proportional hazards model was used to calculate hazard ratios with 95% confidence intervals. Baseline serum PCSK9 concentration predicted incident CVD; concentration in quartile 4 compared with quartile 1 was associated with a hazard ratio of 1.69 (95% confidence interval, 1.30–2.19) after adjustment for sex. Further adjustment for low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, lipoprotein(a), triglycerides, hypertension, diabetes mellitus, smoking, overweight, obesity, physical inactivity, and statin use resulted in a decrease in the hazard ratio to 1.48 (95% confidence interval, 1.12–1.95).

Conclusions—
Serum PCSK9 concentration is associated with future risk of CVD even after adjustments for established CVD risk factors. Further studies are needed to confirm this observation.
Post‐Procedural Troponin Elevation and Clinical Outcomes Following Transcatheter Aortic Valve Implantation
Authors: Koskinas Konstantinos C. , Stortecky Stefan , Franzone Anna , O'Sullivan Crochan J. , Praz Fabien , Zuk Katazyrna , Räber Lorenz , Pilgrim Thomas , Moschovitis Aris , Fiedler Georg M. , Jüni Peter , Heg Dik , Wenaweser Peter , Windecker Stephan 
Published: February 2016

Background

Biomarkers of myocardial injury increase frequently during transcatheter aortic valve implantation (
TAVI
). The impact of postprocedural cardiac troponin (
cT
n) elevation on short‐term outcomes remains controversial, and the association with long‐term prognosis is unknown.

Methods and Results

We evaluated 577 consecutive patients with severe aortic stenosis treated with
TAVI
between 2007 and 2012. Myocardial injury, defined according to the Valve Academic Research Consortium (
VARC
)‐2 as post‐
TAVI
cardiac troponin T (cTnT) >15× the upper limit of normal, occurred in 338 patients (58.1%). In multivariate analyses, myocardial injury was associated with higher risk of all‐cause mortality at 30 days (adjusted hazard ratio [
HR
], 8.77; 95%
CI
, 2.07–37.12;
P
=0.003) and remained a significant predictor at 2 years (adjusted
HR
, 1.98; 95%
CI
, 1.36–2.88;
P
<0.001). Higher
cTnT
cutoffs did not add incremental predictive value compared with the
VARC
‐2–defined cutoff. Whereas myocardial injury occurred more frequently in patients with versus without coronary artery disease (
CAD
), the relative impact of
cTnT
elevation on 2‐year mortality did not differ between patients without
CAD
(adjusted
HR
, 2.59; 95%
CI
, 1.27–5.26;
P
=0.009) and those with
CAD
(adjusted
HR
, 1.71; 95%
CI
, 1.10–2.65;
P
=0.018;
P
for interaction=0.24). Mortality rates at 2 years were lowest in patients without
CAD
and no myocardial injury (11.6%) and highest in patients with complex
CAD
(
SYNTAX
score >22) and myocardial injury (41.1%).

Conclusions

VARC
‐2–defined
cTnT
elevation emerged as a strong, independent predictor of 30‐day mortality and remained a modest, but significant, predictor throughout 2 years post‐
TAVI
. The prognostic value of
cTnT
elevation was modified by the presence and complexity of underlying
CAD
with highest mortality risk observed in patients combining
SYNTAX
score >22 and evidence of myocardial injury.
Effect of statin use on pain relief by transforaminal epidural steroid injection
Authors: Sari Sinem , Aydın Osman Nuri , Tasdemir Banu , Galimberti Fabrizio , Turan Alparslan 
Published: February 2016

Aim To investigate the impact of statin use on response to fluoroscopy-assisted transforaminal anterior epidural steroid injection (TAESI). Methods Patients undergoing TAESI for low back pain were recruited and stratified according to statin use. Pain was evaluated with a visual analogue scale (VAS) before and at 1, 3, and 6 months after TAESI. Health-related quality-of-life was evaluated using the Short Form 36 (SF-36) questionnaire 6 months after TAESI. Results There were no significant differences in VAS scores after TAESI between statin users ( n = 40) and statin nonusers ( n = 253). The SF-36 subgroup: role limitations due to emotional problems score was significantly lower in statin users than statin nonusers. There were no significant between-group differences in any other SF-36 parameter. Conclusion Statin use had no effect on pain scores after TAESI.
Telomerase activates transcription of cyclin D1 gene through an interaction with NOL1
Authors: Hong Juyeong , Lee Ji Hoon , Chung In Kwon 
Published: February 2016

ABSTRACT
Telomerase is a ribonucleoprotein enzyme that is required for the maintenance of telomere repeats. Although overexpression of telomerase in normal human somatic cells is sufficient to overcome replicative senescence, the ability of telomerase to promote tumorigenesis requires additional activities that are independent of its role in telomere extension. Here, we identify proliferation-associated nucleolar antigen 120 (NOL1, also known as NOP2) as a telomerase RNA component (TERC)-binding protein that is found in association with catalytically active telomerase. Although NOL1 is highly expressed in the majority of human tumor cells, the molecular mechanism by which NOL1 contributes to tumorigenesis remained unclear. We show that NOL1 binds to the T-cell factor (TCF)-binding element of the cyclin D1 promoter and activates its transcription. Interestingly, telomerase is also recruited to the cyclin D1 promoter in a TERC-dependent manner through the interaction with NOL1, further enhancing transcription of the cyclin D1 gene. Depletion of NOL1 suppresses cyclin D1 promoter activity, thereby leading to induction of growth arrest and altered cell cycle distributions. Collectively, our findings suggest that NOL1 represents a new route by which telomerase activates transcription of cyclin D1 gene, thus maintaining cell proliferation capacity.
Validation of the Polish version of the Penn Alcohol Craving Scale (PACS)
Authors: Chodkiewicz Jan , Ziółkowski Marcin , Czarnecki Damian , Gąsior Krzysztof , Juczyński Artur , Biedrzycka Beata , Nowakowska-Domagała Katarzyna 
Published: February 2016

CelCelem przeprowadzonych badań było dokonanie polskiej adaptacji Skali Głodu Alkoholu Penn (Penn Alcohol Craving Scale, (PACS) B. Flannery i współpracowników. Skala jest metodą samooceny składającą się z 5 twierdzeń i przeznaczoną do oceny nasilenia głodu alkoholu występującego u pacjenta w tygodniu poprzedzającym badanie.MetodaZbadano 550 pacjentów ze zdiagnozowanym zespołem uzależnienia od alkoholu, a do ostatecznej analizy przyjęto wyniki 510 osób. W badanej grupie znalazło się 396 mężczyzn i 114 kobiet. Badanie przeprowadzono w 3 tygodniu terapii. Zastosowano: Skalę Głodu Alkoholu Penn, Skalę Rozwoju Uzależnienia od Alkoholu (SRUA) (część dotycząca głodu), wywiad kliniczny zawierający specjalnie przygotowane pytania dotyczące odczuwanego w ostatnim miesiącu i tygodniu głodu alkoholu oraz Skalę Yale-Brown Obsesyjno-Kompulsywnego Intensywnego Picia.WynikiPolska wersja Skali Głodu Alkoholu Penn charakteryzuje się bardzo dobrymi właściwościami psychometrycznymi - jest narzędziem rzetelnym i trafnym. Eksploracyjna i konfirmacyjna analiza czynnikowa potwierdziła istnienie jednego czynnika. Zgodność wewnętrzna, oceniona na podstawie alfa Cronbacha, wynosiła 0,89. Metoda wykazuje istotne statystycznie (większość p<0,001) związki z nasileniem głodu w ostatnim roku, miesiącu i tygodniu przed badaniem a także z wynikiem ogólnym w Skali Yale-Brown.WnioskiRezultat przeprowadzonych prac nad adaptacją Skali Głodu Alkoholu Penn przemawia za rekomendowaniem metody do badań naukowych oraz zastosowania w praktyce terapeutycznej.
Polish Adaptation of the Psychache Scale by Ronald Holden and Co-workers
Authors: Chodkiewicz Jan , Miniszewska Joanna , Strzelczyk Dorota , Gąsior Krzysztof 
Published: February 2016

CelCelem badania było dokonanie polskiej adaptacji Skali Bólu Psychicznego Ronalda Holdena i współpracowników (Scale of Psychache). Skala jest metodą samooceny składającą się z 13 twierdzeń i przeznaczoną do oceny subiektywnie odczuwanego bólu psychicznego.MetodaZbadano 300 osób - studentów oraz słuchaczy studiów podyplomowych Uniwersytetu Łódzkiego i Politechniki Łódzkiej. Wśród badanych było 185 kobiet i 115 mężczyzn. Dodatkowo zbadano 150 mężczyzn uzależnionych od alkoholu, 50 współuzależnionych kobiet oraz 50 osób z rozpoznaniem epizodu dużej depresji.WynikiPolska wersja Skali jest narzędziem rzetelnym i trafnym. Eksploracyjna i konfirmacyjna analiza czynnikowa potwierdza istnienie jednego czynnika. Zgodność wewnętrzna, oceniona na podstawie alfa Cronbacha wynosi 0,93. Metoda wykazuje dodatnie, istotne statystycznie związki z poziomem depresji, beznadziejności, lęku i anhedonii oraz ujemne z poziomem optymizmu, zadowolenia z życia i orientacji pozytywnej. Mężczyźni uzależnieni od alkoholu, u których aktualnie stwierdzono występowanie myśli samobójczych charakteryzowali się istotnie wyższym poziomem bólu psychicznego w porównaniu z alkoholikami nie przejawiającymi takich myśli. Wyższy poziom bólu psychicznego odnotowano także u osób z depresją, u których występowały w przeszłości próby samobójcze, w porównaniu z tymi, u których takich prób nie było.WnioskiRezultat przeprowadzonych prac nad adaptacją Skali Bólu Psychicznego przemawia za rekomendowaniem metody do badań naukowych oraz zastosowania w praktyce terapeutycznej.
Polish adaptation of Sexual Addiction Screening Test - Revised
Authors: Gola Mateusz , Skorko Maciej , Kowalewska Ewelina , Kołodziej Aleksandra , Sikora Małgorzata , Wodyk Mateusz , Wodyk Zuzanna , Dobrowolski Paweł 
Published: February 2016

Cel pracyNałogowe zachowania seksualne są coraz częściej spotykane w praktyce psychoterapeutycznej, psychiatrycznej oraz seksuologicznej. Zyskują również coraz więcej uwagi ze strony naukowców. Obecnie dostępnych jest 25 anglojęzycznych kwestionariuszy służących do pomiaru poziomu natężenia utraty kontroli nad zachowaniami seksualnymi. Żadnego z nich nie zaadaptowano do polskich warunków. Celem naszych badań było opracowanie polskiej wersji Sexual Addiction Screening Test (SAST-R) – testu najczęściej używanego w badaniach nałogowych zachowań seksualnych.MetodaOszacowanie właściwości polskiej adaptacji kwestionariusza SAST-R (SAST-PL-M) przeprowadzono na grupie 558 heteroseksualnych mężczyzn.. W grupie tej 116 uczestników stanowiły osoby korzystające z pomocy psychologicznej w związku z nałogowymi zachowaniami seksualnymi, spełniające kryteria zaburzenia hiperseksualnego. Pozostałe osoby nie korzystały nigdy z pomocy psychologicznej, seksuologicznej lub psychiatrycznej w związku ze swoimi zachowaniami seksualnymi.WynikiWartymi podkreślenia cechami SAST-PL-M są jego wysoki współczynnik rzetelności (Alfa Cronbacha = 0,904) oraz dobre właściwości przesiewowe w identyfikowaniu osób z ryzykiem nałogowych zachowań seksualnych (krzywa ROC w odniesieniu do progu 5 na 20 maksymalnych punktów charakteryzuję się czułością = 99,1% i specyficznością = 78,3%).WnioskiSAST-PL-M może być stosowany jako narzędzie do badań przesiewowych pod kątem nałogowych zachowań seksualnych zarówno w badaniach klinicznych, jak i naukowych. Wyniki poniżej 5 punktów wskazują na bardzo niskie prawdopodobieństwo nałogowych zachowań seksualnych, podczas gdy punktacja powyżej 5 punktów wskazuje na potrzebę dodatkowego wywiadu klinicznego dotyczącego zachowań seksualnych. Wyniki SAST-PL-M można porównywać do wyników SAST-R z zagranicznych badań prowadzonych na populacjach heteroseksualnych mężczyzn.
Changing identity, roots, plurality, fluidity: The film and video installations of Singaporean artists
Authors: Teo Phyllis 
Published: February 2016

Abstract
Drawing upon the film and video installations of Singaporean artists Ho Tzu Nyen and Ming Wong, this article aims to make a critical enquiry into methodological and theoretical intersections between film and fine art. Drawing from the cultural particularities of Singapore, there are dimensions in these artists’ works that are relevant for the discussion of an imaginative identification with local histories. Contested issues relating to representation, identity, roots, performativity and history are engaged and negotiated in their works. Ho and Wong foreground the significance of the Malay heritage in the Singaporean identity, notwithstanding being Chinese. The artists are careful to underline the notion that identities are constructed and fluid, and their works reveal a resistance against a singular, constructed definition or an essentialist interpretation of the Singapore national identity, in favour of one that is able to reflect pluralities of diverse societies and the multiplicity of culture. The endeavours to devise alternative modes of exhibition in the art gallery are directed in part at transforming the exhibition environment and how viewers relate to the artwork. In their moving image installations, Ho Tzu Nyen and Ming Wong have developed various visual strategies that explore the dynamic relation between filmic space and time. Proposing a more fluid approach in the understanding of spectatorial positions, both artists have produced a visual and experiential language that enable the audience to develop a new consciousness about their environment and themselves. By engaging the aural-visual, conceptual and physical aspects of the artists’ works, the analysis of the moving image as a series of assertions made within the fields of contemporary art and film seeks to explore new possibilities about what is meant by the ‘cinematic’ in Singapore.
Found materials: Paul Gladston in conversation with Rudi Stanzel
Authors: Gladston Paul , Stanzel Rudi 
Published: February 2016

Abstract
Rudi Stanzel is an artist who lives and works in Vienna. He produces concrete, largely monochrome non-figurative paintings and objects often structured around loosely defined geometric patterns, including grids and stripes, and modular arrangements. Stanzel regards his work as resistant to precise conceptual interpretation. He also eschews conventional painterly concerns with part-by-part composition and spatial illusion, placing emphasis instead on the materiality of surface. Stanzel has taken up positions as an artist in residence in the People’s Republic of China on two occasions: first at the Ningbo Museum of Art from September to December 2006, and subsequently at the Organhouse in Chongqing from September to December 2013.1 In this conversation he discusses the development of his practice as an artist and the impact on that development of local materials appropriated during his residences in China.
Conversations with Chen Shaoxiong and Qian Weikang
Authors: Ding Liu , Lu Carol Yinghua , Wei Su 
Published: February 2016

Abstract
The following conversations with the artists Chen Shaoxiong and Qian Weikang were conducted by Liu Ding, Carol Yinghua Lu and Su Wei as part of their research as curators of the 7th Shenzhen Biennale, ‘Accidental Message: Art is Not a System, not a World’, which was staged in 2012. The interviews were originally published in Mandarin Chinese in Individual Experience: Conversations and Narratives of Contemporary Art Practice in China from 1989 to 2000, a collection of conversations Liu, Lu and Su conducted with artists and curators active in China from 1989 to 2000. Chen Shaoxiong is a founding member of the art groups the Southern Artists Salon and the Big Tail Elephant Group, both of which were formed in Guangzhou – the former in 1986 and the latter in 1990. Qian Weikang was active as a conceptual artist in China during the early to mid-1990s. Both interviews explore the concerns of artists in China during the 1990s as well as the socio-economic, cultural and political circumstances surrounding their practice at the time.
Reviews
Authors: Carrier David , Sanderson Edward 
Published: February 2016

Abstract
Tseng Kwong Chi: Performing for the Camera, Grey Art Gallery, New York University, New York, 21 April–11 July 2015
Contemporary Chinese Art: A Critical History, Paul Gladston (2014) London: Reaktion Books, 256 pp., ISBN: 978-1780232690, paperback, £25.00
Políticas de integración de tecnologías y Formación Inicial de Maestros en Uruguay
Authors: Martínez Barcellos Rosana Elizabeth , Leite Carlinda , Reis Monteiro Angélica María 
Published: February 2016

Este artículo, teniendo como problemática la Formación Inicial de Maestros (FIM) en Uruguay, analiza el lugar que en ella tienen las TIC y cuáles son las influencias (Ball, 1998, 2001; Bowe, Ball & Gold, 1992) que ejercen las políticas internacionales y cómo son recontextualizadas (Bernstein, 1993, 1998). Constituyen preguntas orientadores del estudio: ¿Qué dice la Agenda Global sobre las TIC en la FIM? ¿Qué influencia tienen estas políticas en la FIM? ¿Cómo ocurren procesos de recontextualización? En la componente empírica, el estudio recogió y analizó planes de FIM y entrevistas al director del curso, profesores que aseguran la formación y estudiantes que están realizando su práctica docente. Estos datos, tratados por análisis de contenido, permiten concluir que existe una agenda global que apunta a la necesidad de integración de las TIC en la educación, y como consecuencia de esto, los planes de formación inicial docente deben atender cuestiones que aseguren un uso efectivo de las tecnologías. Esta agenda global influencia las políticas educativas de Uruguay, las que sufren procesos de recontextualización a través de prácticas institucionales que las tienen que adaptar a las necesidades de los estudiantes y profesores. A pesar de eso, a nivel de la formación de maestros, aún es necesario un investimento que permita alcanzar los objetivos hacia los que apuntan las políticas de integración de las TIC.
Multivariate Analysis of Genotype–Phenotype Association
Authors: Mitteroecker Philipp , Cheverud James M , Pavlicev Mihaela 
Published: February 2016

AbstractWith the advent of modern imaging and measurement technology, complex phenotypes are increasingly represented by large numbers of measurements, which may not bear biological meaning one by one. For such multivariate phenotypes, studying the pairwise associations between all measurements and all alleles is highly inefficient and prevents insight into the genetic pattern underlying the observed phenotypes. We present a new method for identifying patterns of allelic variation (genetic latent variables) that are maximally associated—in terms of effect size—with patterns of phenotypic variation (phenotypic latent variables). This multivariate genotype–phenotype mapping (MGP) separates phenotypic features under strong genetic control from less genetically determined features and thus permits an analysis of the multivariate structure of genotype–phenotype association, including its dimensionality and the clustering of genetic and phenotypic variables within this association. Different variants of MGP maximize different measures of genotype–phenotype association: genetic effect, genetic variance, or heritability. In an application to a mouse sample, scored for 353 SNPs and 11 phenotypic traits, the first dimension of genetic and phenotypic latent variables accounted for &gt;70% of genetic variation present in all 11 measurements; 43% of variation in this phenotypic pattern was explained by the corresponding genetic latent variable. The first three dimensions together sufficed to account for almost 90% of genetic variation in the measurements and for all the interpretable genotype–phenotype association. Each dimension can be tested as a whole against the hypothesis of no association, thereby reducing the number of statistical tests from 7766 to 3—the maximal number of meaningful independent tests. Important alleles can be selected based on their effect size (additive or nonadditive effect on the phenotypic latent variable). This low dimensionality of the genotype–phenotype map has important consequences for gene identification and may shed light on the evolvability of organisms.