bluuebunny/crossref_metadata_2025_split huggingface dataset:
EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork–Associated DNA Damage Repair
Authors: Saki Mohammad , Makino Haruhiko , Javvadi Prashanthi , Tomimatsu Nozomi , Ding Liang-Hao , Clark Jennifer E. , Gavin Elaine , Takeda Kenichi , Andrews Joel , Saha Debabrata , Story Michael D. , Burma Sandeep , Nirodi Chaitanya S. 
Published: August 2017

Abstract
EGFR signaling has been implicated in hypoxia-associated resistance to radiation or chemotherapy. Non–small cell lung carcinomas (NSCLC) with activating L858R or ΔE746-E750 EGFR mutations exhibit elevated EGFR activity and downstream signaling. Here, relative to wild-type (WT) EGFR, mutant (MT) EGFR expression significantly increases radiosensitivity in hypoxic cells. Gene expression profiling in human bronchial epithelial cells (HBEC) revealed that MT-EGFR expression elevated transcripts related to cell cycle and replication in aerobic and hypoxic conditions and downregulated RAD50, a critical component of nonhomologous end joining and homologous recombination DNA repair pathways. NSCLCs and HBEC with MT-EGFR revealed elevated basal and hypoxia-induced γ-H2AX–associated DNA lesions that were coincident with replication protein A in the S-phase nuclei. DNA fiber analysis showed that, relative to WT-EGFR, MT-EGFR NSCLCs harbored significantly higher levels of stalled replication forks and decreased fork velocities in aerobic and hypoxic conditions. EGFR blockade by cetuximab significantly increased radiosensitivity in hypoxic cells, recapitulating MT-EGFR expression and closely resembling synthetic lethality of PARP inhibition.
Implications: This study demonstrates that within an altered DNA damage response of hypoxic NSCLC cells, mutant EGFR expression, or EGFR blockade by cetuximab exerts a synthetic lethality effect and significantly compromises radiation resistance in hypoxic tumor cells. Mol Cancer Res; 15(11); 1503–16. ©2017 AACR.
The Estonian-Russian Territorial Sea Boundary Delimitation in the Gulf of Finland
Authors: Lott Alexander 
Published: August 2017

Abstract
In 2014, Estonia and the Russian Federation signed their land and maritime boundary agreements that are currently awaiting ratification. This study reconstructs the maritime boundary delimitation between the two States. In particular, the role of islands and pre-existing agreements for the delimitation of the territorial sea boundary in the south-eastern part of the Gulf of Finland are critically examined. It is established that the agreed maritime boundary line is a median line which was influenced by the use of the special circumstances method in the delimitation process.
ESTHÉTIQUE DU ≪SIGNE PUR≫. ADORNO, MERLEAU-PONTY ET L’ART COMME RÉINVENTION INFINIE DU RÉEL
Authors: Bachofen Blaise 
Published: August 2017

AESTHETICS OF “PURE SIGN” ADORNO, MERLEAU-PONTY AND ART AS AN ENDLESS REINVENTION OF REALITY
Contemporary painting has often dealt with signs, graffiti, calligraphy, and more precisely with aesthetic objects that take the form and appearance of signs, but which do not belong to any existing alphabet. These are forms that imitate signs but are what we might call “pure signs”, i.e. signifiers without a signified. This form of artistic experimentation (of which Paul Klee is the precursor) has elicited parallel and convergent analyses by Merleau-Ponty and Adorno. These authors show the ways in which this kind of artistic experimentation at once renews reflection on language and reflection on art, through a more fundamental reflection on the cognitive actions that they necessarily share, namely deciphering and interpretation. By asking how signs that have no conventional meaning can still be identified as signs–the “decryption” of which is therefore impossible–we re-actualize a question that goes back to Plato and Augustine. How can we begin to investigate and understand what we do not know yet? How does the decryption and interpretation process arise for one who does not yet know if there is something to understand? This type of artwork actually has a meaning, but not in the traditional sense. Although they are unreadable and untranslatable, such works clarifying the meaning of interpretation for us, they free us from a naive and simplistic conception of the process of understanding. They show us that interpretation is always a process of inventing and producing a new meaning, but never of actually finding a pre-existing meaning. In doing so, these kinds of artwork are inseparable from ontological and political issues. Against a conservative view of our relationship to reality, they make us aware that the sense of reality is never simply given nor definitive, and that our relationship to reality contains much more potential than we commonly believe.
Evacuation Decision-Making during Hurricane Matthew: An Assessment of the Effects of Social Connections
Authors: Collins Jennifer , Ersing Robin , Polen Amy 
Published: August 2017

AbstractThis study conducted in Florida examines the relationship between an individual’s social connections and their decision to evacuate during a hurricane warning. Using Hurricane Matthew in 2016 as a case study, a survey was conducted on two groups (those who evacuated and those who did not), assessing one’s social connections considering three dimensions: dependability, density, and diversity. These factors, in addition to socioeconomic variables (e.g., age, race, education), were used to better define a picture for what influences evacuation decision-making. To avoid memory decay, the surveys were completed at the time of the evacuation for those who evacuated and immediately after the passage of Matthew for those who did not evacuate. It was concluded, through statistical analyses, that the perceived dependability of a person’s social connections (i.e., their perceived access to resources and support) played a significant role in the decision to evacuate or not, with non-evacuees having more dependable relationships and having a tightknit community they can rely on during a storm event. On the other hand, the density and diversity of peoples’ social connections did not significantly impact the decision to evacuate. This study has important implications for adding to the knowledge base on community-based sustainable disaster preparedness and resilience.
Social connectedness improves public mental health: Investigating bidirectional relationships in the New Zealand attitudes and values survey
Authors: Saeri Alexander K , Cruwys Tegan , Barlow Fiona Kate , Stronge Samantha , Sibley Chris G 
Published: August 2017

Background: The importance of social connectedness in supporting public mental health is well established. However, the reverse causal pathway (that psychological ill-health leads to reduced social connectedness) remains a dominant perspective among mental health practitioners. Our analysis aimed to provide a rigorous test of the directionality of this relationship. Method: A cross-lagged panel analysis of a large longitudinal national probability sample ( N ≈ 21,227), the New Zealand Attitudes and Values Survey, was used to assess the bidirectional longitudinal relationship between social connectedness and mental health, controlling for baseline levels of both variables and demographics. Results: Social connectedness was found to be a stronger and more consistent predictor of mental health year-on-year than mental health was of social connectedness. Conclusion: These results further demonstrate how the psychological resources conferred by social connectedness can act as a ‘social cure’ for psychological ill-health, and provide the strongest evidence to date for the direction of this relationship in the general community.
Socioeconomic crisis and aggressive behaviour of Greek adolescents
Authors: Lazaratou Helen , Kalogerakis Zacharias , Economou Marina , Xenitidis Kiriakos 
Published: August 2017

Background: Aggressive behaviours are common during adolescence. In Greece, adolescents and their families experience a severe and enduring recession with potentially adverse impact on mental health. Aim: This study aimed to examine the correlation between adolescents’ aggressive behaviour and economic factors. Methods: The Buss–Perry Aggression Questionnaire (AQ) was used to measure aggression. Reduction in pocket money and three items of the Household Food Insecurity Access Scale were used to measure material deprivation as a result of the economic crisis. The questionnaires were administrated to a sample of 2,159 adolescent students of the Greater Athens Metropolitan Area. Results: Students who during the previous 4 weeks had experienced household food insecurity (anxiety/uncertainty about food, insufficient food quality or insufficient food intake) or had their pocket money decreased within the last 6 months scored on average significantly higher in the AQ compared to their counterparts who did not. Conclusion: The shortage in basic goods due to the actual Greek economic crisis seems to be related to aggressive behaviours during adolescence and we should take this into account in clinical practice.
Including the Copenhagen Adduction Exercise in the FIFA 11+ Provides Missing Eccentric Hip Adduction Strength Effect in Male Soccer Players: A Randomized Controlled Trial
Authors: Harøy Joar , Thorborg Kristian , Serner Andreas , Bjørkheim André , Rolstad Linn E. , Hölmich Per , Bahr Roald , Andersen Thor Einar 
Published: August 2017

Background: The FIFA 11+ was developed as a complete warm-up program to prevent injuries in soccer players. Although reduced hip adduction strength is associated with groin injuries, none of the exercises included in the FIFA 11+ seem to specifically target hip adduction strength. Purpose: To investigate the effect on eccentric hip adduction strength of the FIFA 11+ warm-up program with or without the Copenhagen adduction exercise. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: We recruited 45 eligible players from 2 U19 elite male soccer teams. Players were randomized into 2 groups; 1 group carried out the standard FIFA 11+ program, while the other carried out the FIFA 11+ but replaced the Nordic hamstring exercise with the Copenhagen adduction exercise. Both groups performed the intervention 3 times weekly for 8 weeks. Players completed eccentric strength and sprint testing before and after the intervention. Per-protocol analyses were performed, and 12 players were excluded due to low compliance (<67% of sessions completed). The main outcome was eccentric hip adduction strength (N·m/kg). Results: Between-group analyses revealed a significantly greater increase in eccentric hip adduction strength of 0.29 Nm/kg (8.9%; P = .01) in favor of the group performing the Copenhagen adduction exercise, whereas no within-group change was noted in the group that used the standard FIFA 11+ program (–0.02 N·m/kg [–0.7%]; P = .69). Conclusion: Including the Copenhagen adduction exercise in the FIFA 11+ program increases eccentric hip adduction strength, while the standard FIFA 11+ program does not. Registration: Registration: ISRCTN13731446 (International Standard Randomised Controlled Trial Number registry).
Hindrances to achieve professional confidence: The nurse’s participation in ethical decision-making
Authors: Storaker Anne , Nåden Dagfinn , Sæteren Berit 
Published: August 2017

Background: Research suggests that nurses generally do not participate in ethical decision-making in accordance with ethical guidelines for nurses. In addition to completing their training, nurses need to reflect on and use ethically grounded arguments and defined ethical values such as patient’s dignity in their clinical work. Objectives: The purpose of this article is to gain a deeper understanding of how nurses deal with ethical decision-making in daily practice. The chosen research question is “How do nurses participate in ethical decision-making for the patient?” Design and method: We use Gadamer’s philosophical hermeneutics as well as Kvale and Brinkmann’s three levels of understanding in interpreting the data material. Nine registered nurses were interviewed. Ethical considerations: The Ombudsman of Norwegian Social Science Data and the head of the hospital approved the investigation. The participants received both oral and written information about the study and they gave their consent. We informed the participants that the participation was voluntary and that they were free to withdraw at any point in the course of the study. The requirement of anonymity and proper data storage was in accordance with the World Medical Association Declaration of Helsinki (1964). The participants were assured that privacy, and confidentiality would be duly protected. Results: Four key themes emerged: (1) confusion in relation to professional and operational expectations of role, (2) ideal somnolence, (3) inadequate argumentation skills, and (4) compound pressure. Conclusion: Ethical ideals appear to be latent in the mindset of the participants; however, the main finding of this investigation is that nurses need to activate the ideals and apply them into practice. Furthermore, management needs to initiate professional reasoning and interdisciplinary discussions leading to common goals for patients.
Hospitalized adolescents’ perception of dignity: A qualitative study
Authors: Jamalimoghadam Neda , Yektatalab Shahrzad , Momennasab Marzieh , Ebadi Abbas , Zare Najaf 
Published: August 2017

Background: Adolescents can be vulnerable to diminished dignity in the hospital because young people have significantly different healthcare needs than children and adults. They like to cooperate with caregivers only when they get respectful and dignified care. Care without considering dignity can adversely influence the adolescents’ recovery. However, many studies have been conducted on exploring the concept of the patients’ dignity from the adult patients and fewer studies still have explored the dignity of young people. Objective: This study explores the hospitalized adolescents’ perception about dignity. Research design: A conventional qualitative content analysis method was used to explore the meaning of hospitalized adolescents’ dignity. Participants and research context: Hospitalized adolescents in general medical and surgical pediatric units were eligible to participate. Data were obtained through unstructured interviews. Purposive sampling was used and adolescents were recruited until data saturation was reached (n = 13). Ethical considerations: Ethical approval for the study was granted by the Ethics Committee of Shiraz University of Medical Sciences. Participants were provided with information about the purpose, reasons for recording interviews, voluntary participation, and confidentiality of data and interviewees. Findings: Dignity was reflected in four themes: (1) protection of personal privacy, (2) protection of autonomy, (3) respect for identity, and (4) intimate communication. Discussion and conclusion: Hospitalized adolescents stated that healthcare services should protect their personal privacy and autonomy. Also, they should respect the adolescent’s identity and communicate intimately with them to provide the dignity. Adolescence is a discrete developmental stage, with specific healthcare needs which must be addressed effectively by healthcare providers especially nurses.
Radiographic Results and Return to Activity After Sesamoidectomy for Fracture
Authors: Kane Justin M. , Brodsky James W. , Daoud Yahya 
Published: August 2017

Background: Limited data are available comparing the results of lateral sesamoidectomy and medial sesamoidectomy for the treatment of fractures recalcitrant to nonoperative treatment interventions. The hypothesis of this study was that sesamoidectomy for either lateral or medial sesamoid fractures would not change radiographic alignment of the first ray given the use of identical reconstruction of the plantar plate, intersesamoid ligament, and plantar ligament complex at the time of surgery. Methods: This retrospective cohort study compared the outcomes of 46 consecutive patients treated with sesamoidectomy (24 lateral, 22 medial). Patient demographics, mechanisms of injury, and outcomes were recorded. Preoperative, postoperative, and changes in both hallux valgus angle (HVA) and intermetatarsal angle (IMA) were measured. Results: No statistically significant difference could be detected for age ( P = .577), sex ( P = .134), return to activity ( P = 1.000), likelihood to undergo the procedure again ( P = 1.000), orthotic use postoperatively ( P = 1.000), perioperative complications ( P = .497), duration of symptoms ( P = .711), or length of follow-up ( P = .609). While statistically significant changes in preoperative and postoperative alignment were detected for both medial and lateral sesamoidectomy, these changes were not clinically significant. Patients undergoing medial sesamoidectomy had higher preoperative and postoperative HVA and IMA compared with those undergoing lateral sesamoidectomy. Medial sesamoidectomy patients had a net increase in both HVA and IMA, while patients undergoing lateral sesamoidectomy had a net decrease in both HVA and IMA. Conclusion: Although statistically significant changes in both HVA and IMA were detected, these values were too small to be considered clinically significant. Patient outcomes did not differ between the 2 groups, and sesamoidectomy was used with low patient morbidity for both medial and lateral sesamoid fractures that failed to respond to nonoperative modalities. These data suggest that the underlying mechanics of the foot may be different in patients who sustain medial and lateral sesamoid stress injury, suggesting a possible etiologic difference between medial and lateral sesamoid injuries. Level of Evidence: Level III, retrospective cohort study
Is the Walch B3 glenoid significantly worse than the B2?
Authors: Chan Kevin , Knowles Nikolas K. , Chaoui Jean , Ferreira Louis M. , Walch Gilles , Athwal George S. 
Published: August 2017

Background The Walch B3 glenoid is theorized to be a progression of the B2 biconcave pattern. The present study aimed to compare glenoid indices between B2 and B3 patterns. We hypothesized that the B3 pattern would have significantly worse retroversion, inclination and medialization. Methods Computed tomography scans of 50 patients with B2 erosions [mean (SD) age 68 (9) years; 25 male] and 50 patients with B3 erosions [mean (SD) age 72 (8) years; 22 males] were converted into three-dimensional reconstructions. Retroversion, inclination, medialization and humeral head subluxation were compared. Results The data demonstrated no statistically significant differences [mean (SD)] between groups when assessing retroversion: B2 = 21 (8)°, B3 = 24 (7)° ( p = 0.602); glenoid inclination: B2 = 9 (6)°, B3 = 8 (6)° ( p = 0.967); or medialization: B2 = 12 (4) mm, B3 = 14 (4) mm ( p = 0.384). In the B2 group, the mean (SD) humeral head subluxation was 80% (10%) according to the scapular plane and 55% (9%) according to the glenoid plane, which was not statistically different from the B3 group with a mean (SD) humeral head subluxation of 81% (7%) according to the scapular plane ( p = 0.680) and 54% (7%) according to the glenoid plane ( p = 0.292). Conclusions These results demonstrated no significant differences between the B2 and B3 erosion patterns, with respect to the glenoid indicies measured. The aetiology of the B3 glenoid cannot be completely explained by progression of wear in a B2 glenoid.
Total Ankle Arthroplasty: Comparing Perioperative Outcomes When Performed at an Orthopaedic Specialty Hospital Versus an Academic Teaching Hospital
Authors: Beck David M. , Padegimas Eric M. , Pedowitz David I. , Raikin Steven M. 
Published: August 2017

Background. The number of total ankle arthroplasties (TAAs) performed in the United States has risen significantly in recent years, as has utilization of orthopaedic specialty hospital (OSH) to treat healthy patients undergoing elective surgery. The purpose of this study was to compare postoperative outcomes following TAA at an OSH when compared with a matching population of patients undergoing TAA at an academic teaching hospital (ATH). Methods. We identified all TAA from January 2014 to December 2014 at the OSH and January 2010 to January 2016 at the ATH. Each OSH patient was manually matched with a corresponding ATH patient by clinical variables. Outcomes analyzed were length of stay (LOS), 30-day readmissions, mortality, reoperation, and inpatient rehabilitation utilization. Results. There were 40 TAA patients in each group. OSH and ATH patients were similar in age, body mass index, age-adjusted Charlson Comorbidity Index, and gender. Average LOS for TAA at the OSH was 1.28 ± 0.51 compared with 2.03 ± 0.89 (P < .001) at the ATH. There were no OSH patients readmitted within 30 days, compared with 2 ATH patients readmitted (5.0%; P = .15). Two OSH patients (5.0%) and 2 ATH patients (5.0%; P = 1.00) required reoperation. There were no mortalities in either group. There were no OSH patients requiring transfer. Conclusions. Primary TAA performed at an OSH had significantly shorter LOS when compared with a matched patient treated at an ATH with no significant difference in readmission or reoperation rates and may offer a potential source of significant health care savings. Levels of Evidence: Level III: Retrospective cohort study
Getting Better or Getting Well? The Patient Acceptable Symptom State (PASS) Better Predicts Patient’s Satisfaction than the Decrease of Pain, in Knee Osteoarthritis Subjects Treated with Viscosupplementation
Authors: Conrozier Thierry , Monet Matthieu , Lohse Anne , Raman Raghu 
Published: August 2017

Background In the management of knee osteoarthritis (OA), patient-reported-outcomes (PROs) are being developed for relevant assessment of pain. The patient acceptable symptom state (PASS) is a relevant cutoff, which allows classifying patients as being in “an acceptable state” or not. Viscosupplementation is a therapeutic modality widely used in patients with knee OA that many patients are satisfied with despite meta-analyses give conflicting results. Objectives To compare, 6 months after knee viscosupplementation, the percentage of patients who reached the PASS threshold (PASS +) with that obtained from other PROs. Methods Data of 53 consecutive patients treated with viscosupplementation (HANOX-M-XL) and followed using a standardized procedure, were analyzed at baseline and month 6. The PROs were Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function, patient’s global assessment of pain (PGAP), patient’s self-assessment of satisfaction, PASS for WOMAC pain and PGAP. Results At baseline, WOMAC pain and PGAP (range 0-10) were 4.6 (1.1) and 6.0 (1.1). At month 6, they were 1.9 (1.2) and 3.1 (5) ( P < 0.0001). At 6 months, 83% of patients were “PASS + pain,” 100% “PASS + function,” 79% “PASS + PGAP,” 79% were satisfied, and 73.6% experienced a ≥50% decrease in WOMAC pain. Among “PASS + pain” and “PASS + PGAP” subjects, 90% and 83.3% were satisfied with the treatment, respectively. Conclusion In daily practice, clinical response to viscosupplementation slightly varies according to PROs. “PASS + PGAP” was the most related to patient satisfaction.
Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: genomic features and potential therapeutic targets
Authors: Bouska Alyssa , Bi Chengfeng , Lone Waseem , Zhang Weiwei , Kedwaii Ambreen , Heavican Tayla , Lachel Cynthia M. , Yu Jiayu , Ferro Roberto , Eldorghamy Nanees , Greiner Timothy C. , Vose Julie , Weisenburger Dennis D. , Gascoyne Randy D. , Rosenwald Andreas , Ott German , Campo Elias , Rimsza Lisa M. , Jaffe Elaine S. , Braziel Rita M. , Siebert Reiner , Miles Rodney R. , Dave Sandeep , Reddy Anupama , Delabie Jan , Staudt Louis M. , Song Joo Y. , McKeithan Timothy W. , Fu Kai , Green Michael , Chan Wing C. , Iqbal Javeed 
Published: August 2017

Key Points
Adult-mBLs have distinct and more frequent DNA copy number abnormalities compared with pediatric-mBL. Comprehensive genomic analysis revealed that the BCR signaling pathway is a potential therapeutic target in adult-mBL.