bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional evaluation of joint in moderate to severe hemophilia patients treated with on-demand factor replacement: insights from a single hemophilia treatment center in Bangladesh
Authors: Ghosh Sujan , Tory Sanzina Sadia , Nazneen Humayra , Farhad Nurul , Islam Salwa , Hasan Mohammad Jahid , Biswas Akhil Ranjan 
Published: September 2024

Abstract
Background
Hemophilia patients are prone to spontaneous or post-traumatic bleeding, particularly in joints and various other body sites. The high incidence of joint hemorrhages in hemophilia patients underscores the importance of routine joint assessments in clinical care to monitor the condition and evaluate the efficacy of hemophilia treatments.

Aim
This study aimed to assess the joint health of hemophilia patients receiving FVIII or FIX on-demand replacement therapy treatment at a tertiary care hospital in Bangladesh.

Methods
This single-center study involved 93 patients diagnosed with moderate (n = 72;77.4%) and severe (n = 21;22.6%) hemophilia. The assessment of joint health was carried out on six key joints—both elbows, knees, and ankles—using the Hemophilia Joint Health Score (HJHS) version 2.1. Clinical and laboratory data were meticulously documented in a structured questionnaire.

Results
Among the 93 hemophilic patients, the majority had hemophilia A (96.8%). The median HJHS of the patients was 15 (IQR:9.5–20) with the knee joint being mostly affected (88.2%). A significant positive correlation was observed between HJHS and age (r = 0.385, p < 0.001) and total number of joints involved (r = 0.405, p < 0.001). No significant association was found between factor level, education status, and socio-economic status with HJHS score.

Conclusion
Early assessment and monitoring of joint health are essential in clinical practice to prevent severe complications in hemophilia patients.
Tubercular tracheobronchial amyloidosis: a rare complication presenting as an endobronchial mass — a case report
Authors: Dsouza Juvena Jebeleen Tony , Samdesi Abhishek , Mohapatra Aswini Kumar 
Published: September 2024

Abstract
Background
Pulmonary amyloidosis often occurs as a part of systemic AL (amyloid light chain) amyloidosis. Localized tracheobronchial amyloidosis is a very rare entity. Most often, it is asymptomatic, or if symptomatic, it usually presents with vague symptoms such as cough, dyspnoea, hoarseness, wheezing, haemoptysis, and rarely respiratory failure. It is commonly misdiagnosed as asthma, tuberculosis, COPD, malignancy, or pneumonia.

Case presentation
We are presenting a case of an elderly male, aged 64 years, who presented with symptoms of productive cough, dyspnoea, wheezing, and significant weight loss over a period of 6 months. Investigations such as bronchoscopy, histopathology, and imaging studies showed an endobronchial mass and left-sided pleural effusion.

Conclusions
Endobronchial amyloidosis generally has a nodular appearance which can imitate an endobronchial tumour. The quality of life is decreased in these patients, and the life expectancy is approximately 8–10 years. Therefore, the early diagnosis of this disease is essential.
Effect of strength-based physical exercise on telomere length as a marker of premature ageing in patients with schizophrenia: study protocol for a pilot randomised controlled trial
Authors: Sánchez-González Juan Luis , Juárez-Vela Raúl , Dutil Muñoz de la Torre Virginia , Andrés-Olivera María del Pilar , Martín-Vallejo Javier , Morán-Bayón Álvaro , Gonçalves-Cerejeira Joana Isabel , Gestoso-Uzal Nerea , González-Sarmiento Rogelio , Pérez Jesús 
Published: September 2024

Background
Patients with schizophrenia die decades earlier than the general population. Among the factors involved in this mortality gap, evidence suggests a telomere length shortening in this clinical population, which is associated with premature ageing. Recent studies support the use of strength-based training exercise programmes to maintain, or even elongate, telomere length in healthy elderly populations. However, studies aiming at modifying telomere length in severe mental illnesses, such as schizophrenia, are still very scarce.

Aims
To investigate the effect of a strength-based physical exercise programme on the telomere length of individuals with schizophrenia.

Method
We propose a pragmatic, randomised controlled trial including 40 patients aged ≥18 years, with a stable diagnosis of schizophrenia, attending the Complejo de Rehabilitación Psicosocial (CRPS, Psychosocial Rehabilitation Centre) in Salamanca, Spain. These patients will be randomly assigned (1:1) to either receive the usual treatment and rehabilitation programmes offered by CRPS (treatment-as-usual group) or these plus twice weekly sessions of an evidence-based, strength-based training exercise programme for 12 weeks (intervention group). The primary outcome will be effect on telomere length. Secondary outcomes will include impact on cognitive function, frailty and quality of life.

Results
We expect to show the importance of implementing strength-based physical exercise programmes for patients with schizophrenia. We could find that such programmes induce biological and genetic changes that may lengthen life expectancy and decrease physical fragility.

Conclusions
We anticipate that our trial findings could contribute to parity of esteem for mental health, reducing premature ageing in patients with severe mental illnesses, such as schizophrenia.
Organizational Implementation of Exercise Is Medicine® On Campus Programs
Authors: Howie Erin K. , Harden Samantha M. , Jett Kristin M. , Gallagher Kaitlin M. , Tompkins Connie L. , Leininger Lisa J. , Peterson Neil E. 
Published: September 2024

ABSTRACT

Introduction
The Exercise is Medicine® On Campus (EIM-OC) program, a physical activity initiative for universities, has a high potential for scalability and sustainability. Through EIM-OC’s recognition program, campuses achieve Gold-level status through the implementation of exercise referral. The current implementation and effectiveness of EIM-OC referral programs to increase student physical activity or health is largely unknown. The purpose of this study was to determine the implementation of the EIM-OC referral process and current assessments of effectiveness.

Methods
A cross-sectional survey of EIM-OC representatives currently at Gold-level campuses was conducted between April 1 and August 1, 2023, using the Practical, Robust Implementation and Sustainability Model (PRISM) framework.

Results
Thirty-three of 85 contacted campuses submitted complete responses. Of the eight campuses reporting all physical activity screening information, a total of 5682 individuals were screened. Of those who were screened, 356 (6.3%) individuals were referred to an exercise professional, with 135 (38.0%) following through with the referral. Half of campuses collected additional physical activity information (e.g., self-report surveys or accelerometers), 30% collected physical health (e.g., anthropometrics or blood) and/or mental health (e.g., depression symptoms or quality of life) measures, and 15% collected educational outcomes (e.g., grades). Approximately 20% of campuses reported a willingness to share data in a repository, depending on the measure, with others sharing concerns of confidentiality and institutional review board limitations. Only 36% of responding campuses tracked physical activity or health outcomes following the initial visit to assess effectiveness. Exercise programs included personal training only (n = 10), exercise prescription/health coaching (n = 12), or both (n = 8).

Conclusion
Although Gold-level campuses are generally successful in the assessment of physical activity, strategies are needed to improve the reach of EIM-OC programs, specifically implementation strategies to increase the number of individuals screened and successful follow-ups. Additional standardized measures and tracking are needed to determine the effectiveness of EIM-OC programs on improving student physical activity and health.
Chyme reinfusion in a clinical setting
Authors: Steensgaard Maja , Cooper Laura , Staub Ditte , Salling Ida , Bager Palle 
Published: September 2024

Background: Patients with ileostomies may develop intestinal failure and high stoma output. Chyme reinfusion (CR) was considered an alternative to parenteral nutrition. The Insides System, a closed system for CR, was introduced to allow complete patient control and management. In this paper the authors used the system for 3 years and aimed to describe its use in clinical practice. Methods: A cohort of patients considered for the system was included in the study. They were followed from screening until discontinuation of the system. Data on health-related quality of life were collected, and journal audits were performed. Results: A total of 14 patients were included in the results. Two did not receive the system, four answered the questionnaires one time or less and four had the system discontinued before discharge. Answers from the remaining four patients were inconclusive. The audit revealed that evaluating patient compliance and motivation was key before introducing the system. With the system in place, pain and discomfort levels were found to be important for the patients. Conclusion: The Insides System was feasible in a clinical practice setting. However, comprehensive screening was necessary, with specialised nurses playing a key role.
Effect of Personalized Nutrition Combined with Acceptance and Commitment Therapy on Psychological Resilience, Quality of Life and Side Effects of Chemotherapy in Patients with Advanced Gastric Cancer
Authors: Hu Haiping , Li Hefa , Xu Huixia , Liu Jiayin , Qi Yue 
Published: September 2024

Aims/Background Gastric cancer is a common and life-threatening cancer, which predisposes patients to certain psychological problems. Implementation of both personalized nutrition and acceptance and commitment therapy (ACT) have shown unique advantages in the treatment of cancer patients. This study aims to evaluate the effects of this comprehensive therapy on psychological resilience, quality of life and side effects of chemotherapy in patients with advanced gastric cancer (AGC), yielding findings that can inform the development of holistic and effective treatment methods. Methods The clinical data of 240 AGC patients who underwent chemotherapy in the Fourth Hospital of Hebei Medical University from February 2021 to February 2023 were retrospectively analyzed. After excluding 15 patients who did not meet the inclusion criteria, 225 patients were included in the study. According to the management methods, the patients were divided into three groups: group A receiving routine management (n = 76), group B receiving routine management plus personalized nutrition (n = 75), and group C receiving routine management, personalized nutrition and ACT (n = 74). The psychological resilience, quality of life and side effects of chemotherapy were evaluated in the three groups. Results There was no difference in the Connor-Davidson resilience scale (CD-RISC) scores and quality of life questionnaire-core 30 (QLQ-C30) scores among the three groups at admission (p > 0.05). After chemotherapy, compared with the group C, the CD-RISC scores of group A and group B were significantly lower (p < 0.001), and the scores of physical function, cancer-related symptoms and overall health in group A and group B were significantly lower (p < 0.001). The incidence of side effects of chemotherapy in group C was 25.68%, which was significantly lower than that in group A and group B (p < 0.05); there was no statistical difference in this regard between group A and group B (p > 0.05), and the same parameter was significantly different between group A and group C (p < 0.05). Conclusion Personalized nutrition management plus ACT has a significant favorable effect on improving psychological resilience, alleviating the side effects of chemotherapy, and enhancing the quality of life in patients with AGC undergoing chemotherapy.
Performance prediction of a closely spaced dual port dual-band silicon-graphene antenna with high isolation for THz wireless applications using a machine learning algorithm
Authors: Kumar Thakur Gopal , Kulkarni Shridhar , Kumar Lov , Jain Rakhee 
Published: September 2024

This article explains the design and
optimization of a twin port silicon-graphene
radiator in the THz frequency
regime. The suggested
radiator’s primary attributes are: 1) a plus-formed slot
produces dual radiating mode (HEM11δ and HEM12δ) inside the ceramic; 2) the
presence of an absorber wall in between the twin port blocks the
radiation between the ports and raises the separation level to above
35 dB as well; 3) using a graphene sheet over ceramic
and metasurface (MS) provides the tunability in the proposed radiating
structure; and 4) machine learning procedures, i.e., ANN
and random forest, help to predict the expected S-parameters of the
planned antenna. Actual (HFSS/CST software) and projected values
(using the ML algorithm) confirm that the design radiator works
effectively in the twin working spectrum, i.e., 3.3–3.98 and
4.9–5.45 THz. A good value of the far-field and MIMO parameters
confirms its applicability in THz-built biomedical uses.
Refractive blur’s influence on discomfort glare perception from white LED headlights at night
Authors: Iizuka Tatsuya , Kawamorita Takushi , Ishikawa Hitoshi 
Published: September 2024

This study examined the effects of refractive blur on discomfort perception caused by peripheral glare from white LED passing (low)-beam headlights at night. The study compared two levels of binocular blur (+0.50 diopter [D] and +1.00D) against a baseline of optimal refractive correction. Thirty participants (mean age 21.3±1.6 years; range 20–24 years) simulating a driving position assessed discomfort from glare sources (headlights of oncoming vehicles) located at 40 and 20 m distances using the de Boer scale. The study found that, with a blur of +0.50D, discomfort glare from white LED headlights did not significantly differ from the baseline regarding de Boer scores. However, with a blur of +1.00D, de Boer scores significantly decreased, indicating increased discomfort glare compared with the baseline for all distances (P=0.004). These results suggest that refractive blur may contribute to an increased perception of discomfort glare during nighttime driving.
Impact of pyrazinamide usage on serious adverse events in elderly tuberculosis patients: A multicenter cohort study
Authors: Yoon Joon Young , Kim Tae-Ok , Kim Ju Sang , Kim Hyung Woo , Lee Eung Gu , Jung Sung Soo , Oh Jee Youn , Kim Jin Woo , Lee Sang Haak , Kim Seunghoon , Kim Sun-Hyung , Park Yeonhee , Min Jinsoo , Kwon Yong-Soo 
Published: September 2024

BackgroundPyrazinamide (PZA) usage has been associated with adverse drug reactions, prompting its avoidance in treating elderly tuberculosis (TB) patients. This study aims to examine whether the administration of PZA is associated with poor outcomes during TB treatment among elderly individuals.MethodsA retrospective analysis was undertaken on data collected from a prospective cohort conducted between July 2019 and June 2023, which involved tuberculosis patients from 18 institutions across the Republic of Korea. The study aimed to assess the impact of PZA on the incidence of serious adverse events (SAEs), medication interruptions, and becoming loss to follow-up (LTFU) during standard short courses of TB treatment in elderly (≥65 years old) patients.ResultsPZA was administered to 356 of 390 elderly patients (91.3%), and 98 of the 390 (25.1%) experienced SAEs. Treatment success was significantly lower in patients not treated with PZA compared to those who received PZA (64.7% vs 89.9%, p < 0.001). The incidence of SAEs, medication interruption, or LTFU was higher in patients not given PZA compared those who received PZA (52.9% vs. 27.2%, p = 0.002). A multivariate logistic regression analysis, factoring in covariates such as age, comorbidities, and baseline laboratory data, revealed that PZA was not a risk factor for SAEs, medication interruption, or LTFU in TB treatment (odds ratio [OR] 0.457, 95% confidence interval [CI] 0.201–1.041).ConclusionTreating elderly TB patients with PZA did not increase the incidence of SAEs, medication interruptions, or LTFU during the standard short course of TB treatment. Therefore, considering its potential advantages, incorporating PZA into the treatment regimen for elderly TB patients may be advisable.
Belonging through meaningful activity in the transition from unhoused to housed
Authors: Plett Patti , Gewurtz Rebecca , Oudshoorn Abe , Forchuk Cheryl , Marshall Carrie Anne 
Published: September 2024

Background
Belonging is closely associated with well-being, yet individuals with experiences of being unhoused are likely to experience social exclusion and challenges with developing a sense of belonging. Engagement in meaningful activity has been linked to belonging; however, there are no focused studies exploring experiences of how engaging in meaningful activities influences belonging. Meaningful activities are things we do that bring value to our lives.

Purpose
To explore how engaging in meaningful activities may influence experiences of belonging following homelessness through a secondary analysis of qualitative interviews.

Method
Using interviews conducted in a community-based participatory action study exploring the transition to housing following homelessness (n = 19), we conducted a thematic analysis using the method described by Braun and Clarke. Participants were recruited through communication with local organizations supporting individuals with lived and living experiences of being unhoused as well as through presentations at drop-in organizations. An intentional effort was made to recruit diverse participants regarding housing status, age, and gender. Inductive analysis was used to conduct initial coding, focusing on belonging and engaging in meaningful activities. We then analyzed the codes abductively, using Bourdieu’s Social Capital Theory to inform this analysis.

Findings
The overarching essence generated in our analysis was: “I don’t feel like I belong…everything in the world is not for me…it’s for people with…enough money to…enjoy those things”. Within this overall essence, we generated three themes: 1) Human connection: “being where I am with people who care about me, I actually feel good”; 2) Social exclusion: being a “regular member of society”; and 3) Non-human connection: “my cats…are like my kids to me.” Participants described numerous contextual factors that challenged them as they sought belonging following homelessness, including financial limitations and other societal factors.

Conclusion
Our findings suggest that meaningful activity was an important pathway to belonging for participants in this study.
Impact of sinus surgery in people with cystic fibrosis and chronic rhinosinusitis in the era of highly effective modulator therapy: Protocol for a prospective observational study
Authors: Liu Christine M. , Fischer Jakob L. , Alt Jeremiah A. , Bodner Todd E. , Chowdhury Naweed I. , Getz Anne E. , Hwang Peter H. , Kimple Adam J. , Mace Jess C. , Smith Timothy L. , Soler Zachary M. , Goss Christopher H. , Taylor-Cousar Jennifer L. , Saavedra Milene T. , Beswick Daniel M. 
Published: September 2024

Introduction
Cystic fibrosis (CF) is commonly complicated by chronic rhinosinusitis (CRS). Despite highly effective management options, CRS in people with CF (PwCF+CRS) may be refractory to medical therapy, eventually requiring endoscopic sinus surgery. The impact of sinus surgery on pulmonary, quality of life (QOL), and other outcomes in PwCF+CRS in the expanding era of highly effective modulator therapy has not been fully elucidated. This study aims to determine if endoscopic sinus surgery can offer superior outcomes for PwCF+CRS when compared to continued medical treatment of CRS.

Methods and analysis
This multi-institutional, observational, prospective cohort study will enroll 150 adults with PwCF+CRS across nine US CF Centers who failed initial medical therapy for CRS and elected to pursue either endoscopic sinus surgery or continue medical treatment. To determine if sinus surgery outperforms continued medical therapy in different outcomes, we will assess changes in pulmonary, CF-specific QOL, CRS-specific QOL, sleep quality, depression, headache, cognition, olfaction, productivity loss, and health utility value after treatment. The influence of highly effective modulator therapy on these outcomes will also be evaluated. This study will provide crucial insights into the impact of endoscopic sinus surgery for PwCF+CRS and aid with development of future treatment pathways and guidelines.

Ethics and dissemination
This study has been approved by each institution’s internal review board, and study enrollment began August 2019. Results will be disseminated in conferences and peer-reviewed journals.

Trial registration
This study was registered on ClinicalTrials.gov (NCT04469439).
Interferencia por macrocomplejos B12: hacia una detección eficaz e interpretación correcta de la hipo e hipervitaminemia
Authors: Delgado Jose Antonio , Pastor María I. , Costa Gemma , Márquez Nuria , Bauça Josep Miquel 
Published: September 2024

Resumen

Objetivos
Los resultados indicativos de hipervitaminemia B12 pueden deberse a la presencia de macro B12. Las biomoléculas de alto peso molecular se pueden eliminar mediante precipitación con polietilenglicol (PEG). Sin embargo, con esta técnica, se pueden coprecipitar moléculas “libres,” por lo que es necesario establecer nuevos valores de referencia para el resultado post precipitación. Los objetivos principales del presente estudio son: 1) Establecer intervalos de referencia (IR) post-PEG para la vitamina B12. 2) Comparar los dos criterios establecidos en la literatura para determinar la presencia de macro B12; 3) Evaluar la utilidad conjunta del porcentaje de recuperación de vitamina B12 post PEG y de los intervalos de referencia post PEG, para determinar el estado real de vitamina B12 en el organismo; y 4) Proponer comentarios para facilitar la interpretación de los resultados.

Métodos
Se realizó un estudio prospectivo en el que se analizaron 488 muestras séricas de individuos “sanos” para determinar el porcentaje de recuperación y los intervalos de referencia tras la precipitación con PEG. Posteriormente, se realizó un análisis retrospectivo para evaluar la utilidad conjunta de ambas definiciones ante la sospecha de la presencia de macro B12. Se incluyó un total de 297 casos.

Resultados
La recuperación y los IR post-PEG, determinados con la plataforma Alinity i oscilaron entre el 60 % y el 107 % y entre 118 y 506 pmol/L, respectivamente. La prueba de McNemar reveló diferencias estadísticamente significativas entre los dos criterios a la hora de estimar la interferencia. Sin embargo, ambas metodologías mostraron un elevado nivel de concordancia. En los 27 casos, la presencia de macro-B12 coincidió con hipervitaminemia de B12 confirmada. En ningún caso, la presencia de macro B2 coincidió con un déficit de B12.

Conclusiones
Se debería incluir en los informes analíticos la concentración total de vitamina B12, el porcentaje de recuperación y la concentración de vitamina B12 post PEG, así como sus IR ajustados, con el fin de poder evaluar con mayor precisión el estado de la vitamina en el organismo.