bluuebunny/crossref_metadata_2025_split huggingface dataset:
Familial Nonautoimmune Hyperthyroidism Due to a TSH Receptor Gene Pathogenic Variant
Authors: Takahashi Sawako , Nishihara Eijun , Fukata Shuji , Miyauchi Akira , Akamizu Takashi 
Published: September 2024

Abstract
Familial nonautoimmune hyperthyroidism (NAH) is a rare type of autosomal dominant hyperthyroidism caused by constitutively active pathogenic variants of the thyrotropin receptor (TSHR) gene. Although affected family members present with varied levels of hyperthyroid features, even when the same pathogenic variant is present, total thyroidectomy followed by radioiodine therapy is recommended for long-term management. Herein, we present the case of an 18-year-old proband and her family members with NAH (TSHR-I640V), who presented with diverse thyroid dysfunctions: fluctuations between euthyroid and subclinical hyperthyroidism, mild hyperthyroidism, and overt hyperthyroidism. Almost all affected adult family members, except the proband, showed no progression of hyperthyroidism or thyroid enlargement. A family history of thyrotropin receptor antibodies (TRAb)-negative hyperthyroidism is important for the identification of NAH in adults before TSHR genetic testing can be performed. Ablative therapy is not necessary when familial NAH presents with late-onset mild hyperthyroidism without coexisting diseases.
Rewriting the Literary Past: D. H. Lawrence and Geoff Dyer’s Antibiography
Authors: Koenig Andrew 
Published: September 2024

Abstract
Why do memoirists, in order to find themselves, find it necessary to rewrite their favorite authors? This article explores this question by analyzing D. H. Lawrence and Geoff Dyer and tracing Dyer’s conflicted attitude to memoir and rewriting back to Lawrence, specifically his Study of Thomas Hardy. If by now the book market is awash in antibiographical rewrites, that is because rewriting first asserted itself as a contrarian impulse, a radically different way of thinking about the canon that has become second nature.
Beyond Chatbot-K: On Large Language Models, “Generative AI,” and Rise of Chatbots—An Introduction
Authors: Goodlad Lauren M. E. , Stone Matthew 
Published: September 2024

Abstract
This essay introduces the history of the “generative AI” paradigm, including its underlying political economy, key technical developments, and sociocultural and environmental effects. In concert with this framing it discusses the articles, thinkpieces, and reviews that make up part 1 of this two-part special issue (along with some of the content for part 2). Although large language models (LLMs) are marketed as scientific wonders, they were not designed to function as either reliable interactive systems or robust tools for supporting human communication or information access. Their development and deployment as commercial tools in a climate of reductive data positivism and underregulated corporate power overturned a long history in which researchers regarded chatbots as “misaligned” affordances for safe or reliable public use. While the technical underpinnings of these much-hyped systems are guarded as proprietary secrets that cannot be shared with researchers, regulators, or the public at large, there is ample evidence to show that their development depends on the expropriation and privatization of human-generated content (much of it under copyright); the expenditure of enormous computing resources (including energy, water, and scarce materials); and the hidden exploitation of armies of human workers whose low-paid and high-stress labor makes “AI” seem more like human “intelligence” or communication. At the same time, the marketing of chatbots propagates a deceptive ideology of “frictionless knowing” that conflates a person's ability to leverage a tool for producing an output with that person's active understanding and awareness of the relevant information or truth claims therein. By contrast, the best digital infrastructures for human writing enable human users by amplifying and concretizing their interactive role in crafting trains of contemplation and rendering this situated experience in shareable form. The essay concludes with reflections on alternative pathways for developing AI—including communicative tools—in the public interest.
Effects of blood extraction and ecophysiological experiments on stress in adult males of Liolaemus attenboroughi
Authors: Duran Fernando , Medina Marlin S. , Ibargüengoytía Nora R. , Boretto Jorgelina M. 
Published: September 2024

ABSTRACT
Stress during laboratory experiments can affect the outcomes of ecophysiological studies. The serum corticosterone concentration (CORT), the leukocyte profile, heterophil/lymphocyte ratio (H/L), and the presence of blood endoparasites were analyzed as a proxy of stress and immunological state in adult males of the lizard Liolaemus attenboroughi, endemic to Patagonia, Argentina. The results of the ecophysiological variables (preferred temperature, running speed, locomotor endurance, and body condition index, BCI) were analyzed in relation to stress indicators obtained from blood samples taken at three different times: at capture, and on the third and seventh days in the laboratory. Males at capture showed a high percentage of lymphocytes and heterophils and a low of basophils, monocytes, and eosinophils. Haemogregorina-type endoparasites have been recorded in the genus Liolaemus for the first time. The proportion of infected males remained stable during captivity; however, these males showed higher CORT levels, increased percentages of basophils, and decreased percentages of lymphocytes. There was a significant increment in CORT and H/L, and a decrease in BCI during laboratory experiments, compared with baseline values at capture. The performance was not related to the CORT or the repeated blood sampling. The BCI decreased, possibly due to energy reserve mobilization caused by acute stress. This study shows that blood extraction and ecophysiological experiments over 7 days have a minor effect on the stress indicators used.
SOME BIOLOGICAL AND ECOLOGICAL FEATURES OF HYPODERMA LATREILLE, 1818 IN TAVUSH REGION OF ARMENIA
Authors: Grigoryan Valery V. , Shcherbakov Oleg V. , Abrahamyan Viktor V. , Yeribekyan Spartak V. , Grigoryan Liana H. 
Published: September 2024

Background. Cattle hypodermosis is a chronic parasitic disease (entomosis) that occurs as a result of parasitizing the larvae of warble flies in the body of animals. Disease is common in more than 55 countries of the world, causing great economic damage. It is considered as a parasitic disease with a certain zoonotic potential.
Purpose. To conduct research on biological and ecological features of the warble flies that determines certain epidemiological traits of the caused pathology in Tavush Region of Armenia.
Materials and methods. The observations were carried out in Tavush Region, and the experiments were carried out at the Research Center for Veterinary Medicine and Veterinary Sanitary Expertise at the Armenian National Agrarian University. The warble flies marked with stain, were released at a distance of 0.5 to 1.5 km from livestock farms with subsequent search and trapping of insects, located on pastures and on the skin of animals. Generally, 275 warble flies were released. Warble fly activity was evaluated visually counting the comparative number of flying insects at the fixed point per minute at different times of the day, as well as animal anxiety state caused by warble flies was identified. Statistical processing of experimental data was performed by means of “Vassart.net” online calculator.
Results. Female warble flies Hypoderma bovis flew up to 12.1 km, while female warble flies H. lineatum did it up to 8.6 km. Females of H. bovis and H. lineatum demonstrated various spatial and circadian flying activity that depends on season, and altitude above the sea level. Spring generation of warble flies is more resistant to low air temperatures compared to the summer generation. Mild and humid summers, as well as an increase in the number of animals, contribute to an increase in the population of warble flies, while high temperature and high soil moisture contribute to the mass death of warble fly pupae developing in the ground.
Conclusion. The research data cited in the article, detect the presence of a wide range of biocenotic factors that determine the epidemiology of cattle hypodermosis in the Tavush region of the Republic of Armenia. Cattle hypodermosis control plan was designed based on the results of the research, as well as natural and climatic conditions of Tavush region. Pasture prevention activities and periodic treatment of the cattle with insecticides were emphasized.
SPRING WHEAT IN THE DRY CLIMATE OF THE LOWER VOLGA REGION OF RUSSIA
Authors: Solonkin Andrey V. , Sukhareva Elena P. , Belikina Anna V. 
Published: September 2024

Background. The growing of spring wheat in arid conditions is a difficult task because the biological characteristics of the crop and its demands on moisture reserves. The need for sowing spring wheat in the spring is dictated by the possible death of winter grains in winter.
Purpose. To determine the most adaptive varieties of spring wheat with high yield and good quality for cultivation in the dry climate of the Lower Volga region of Russia.
Methods. To achieve this goal, an environmental test of spring wheat varieties was carried out by us; the harvest results were processed by analysis of variance. To characterize weather conditions, the hydrothermal coefficient was calculated according to T.G. Selyaninov. An analysis of the ability of varieties to adapt to local climatic conditions was carried out using the coefficient of adaptability, stress resistance and compensatory ability of varieties. The graph was constructed and statistical data processing was carried out in Microsoft Excel 2008.
Result. As a result of the research work, it was established that on average over three years of research, the highest yield of spring wheat was in the following varieties: Saratovskaya 73 -1.65 t/ha, Kamyshinskaya 3 - 1.32 t/ha, Bezenchukskaya 205 - 1, 4 t/ha. Processing of spring wheat harvest data are used by dispersion analysis made it possible to determine that the gross harvest of the crop is largely influenced by meteorological conditions, up to 42.0%, the choice of variety is about 19.7%, and agrotechnological and other environmental factors are 38.2%. It can be noted that spring soft wheat in the conditions of the Lower Volga region is capable of producing grain yields of good quality with large grains from 31.2 to 36.4 g of 1000 grains.
Analysis of indicators of the level of resistance to drought conditions shows that the most stress-resistant varieties are: Zinaida - 0.06 t/ha, Kamyshinskaya 3 - 0.24 t/ha, Albidum 188 - 0.24. The varieties that have the highest genetic flexibility in the conditions of the Lower Volga region are: Saratovskaya 73 - 1.72 t/ha, Bezenchukskaya 205 - 1.5 t/ha and Kamyshinskaya 3 - 1.32 t/ha. The spring wheat varieties Bezenchukskaya 205 have the highest responsiveness to changes in crop growth conditions - 0.12, Dobrynya is in second place - 0.14, Albidum is in third place, Kamyshinskaya 3 - 0.15. The adaptability coefficient is higher than 1 in the varieties Albidum 188, Kamyshinskaya 3, Saratovskaya 73, Prokhorovka, Zinaida.
Conclusion. The varieties Saratovskaya 73 and Kamyshinskaya 3 are distinguished by yield, stress tolerance, genetic adaptability to dry climate.
Conservative treatment of adolescent idiopathic scoliosis (AIS): A narrative review of current evidence and implications for clinical practice
Authors: Błachnio Klaudia , Kopciał Szymon , Piecuch Dawid , Hańczyk Edyta 
Published: September 2024

Introduction and purpose: Adolescent idiopathic scoliosis (AIS) is characterized by lateral curvature, vertebral rotation, and disruption of physiological curvature of the spine with the Cobb angle ≥10°. AIS affects 1-3% of children aged 10-16 years, representing the most common form of idiopathic scoliosis. Diagnosis of AIS is by exclusion and can be suspected based on Adams forward bend test and scoliometer. Untreated AIS can lead to serious consequences, such as progression of the deformity, back pain, reduced respiratory and cardiovascular function. The aim of this review is to update overview of conservative treatment options.
Description of the state of knowledge: AIS treatment guidelines from the Scoliosis Research Society (SRS) and the Scientific Society on Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT) advocate for observation, bracing, or surgery depending on curve severity, with a focus on avoiding spinal fusion when possible. Additionally, SOSORT recommends scoliosis-specific physiotherapy exercises for smaller curves or as an adjunct to bracing. Conservative treatment aims to prevent curve progression, manage respiratory and spinal complications, and improve quality of life.
Conclusions: AIS can significantly impair the physical and psychosocial well-being of young patients, with potential long-term consequences extending into adulthood Individualized treatment plans and patient/parent education are crucial for optimal outcomes. Schroth exercises are superior to Core Stabilization (CS) exercises in reducing Cobb angle, trunk rotation and improving spinal mobility, cosmetic trunk deformities and quality of life. CS exercises are more effective in increasing peripheral muscle strength, reducing pain and correcting vertebral rotation.
Leopolda Buczkowskiego zapiski wojenne. Kilka uwag z perspektywy edytora
Authors: Libich Maciej 
Published: September 2024

Artykuł stanowi rekapitulację problemów, z jakimi musi zmierzyć się edytor zapisków wojennych Leopolda Buczkowskiego (1905–1989). Autor szkicu, inspirując się teoriami z zakresu antropologii literatury i krytyką genetyczną, omawia materialne i pozatekstowe aspekty notatek czasu okupacji, które jego zdaniem domagają się odzwierciedlenia w edycji. Podejmuje też krytykę dotychczasowych opracowań dzienników Buczkowskiego, zwracając uwagę na niewystarczające zainteresowanie edytorów takimi kwestiami jak materiały piśmiennicze, którymi posługiwał się Buczkowski. Wreszcie wspomina o pomijanym dotąd przez badaczy maszynopisie utworu Buczkowskiego pod tytułem Rafał Bajc, postulując uwzględnienie go jako kontekstu dla wojennych zapisków.
Factors reported by the participants in group therapy for intimate partner perpetrators as helping
Authors: Pullinen Maria , Seppänen Saara , Tapola Vojna , Holma Juha 
Published: September 2024

Little is known about the factors that facilitate change in interventions designed for intimate partner perpetrators. This qualitative study examined factors perpetrators in a voluntary-based batterer programme had experienced as having helped them reduce their intimate partner violence. The data were drawn from video-recorded group meetings.
The data comprised recordings of 30 videotaped weekly group sessions held over a two-year period. The data were analysed by data-driven content analysis. We also examined which of the participants – facilitators or perpetrators – initiated discussion on factors helpful in reducing intimate partner violence
Multiple factors that perpetrators had found useful in reducing their violent behaviours were found: New skills, Changes in attitudes and ways of thinking, Receiving peer support in the group, and Increased personal well-being and functioning. These factors might be connected as part of a process of critical self-reflection which was enabled through reduced feelings of shame and increased empathy. These discussions began at the initiative of the facilitator or group members, by sharing the experiences of another group member, or by open-ended questions from group members to others.
CaF2/TiO2 nanophotonic biosensor based on a one-dimensional photonic crystal for Chikungunya virus detection
Authors: Aly Arafa H. , Mohamed B. A. , Al-Dossari M. , Mohamed D. , Awasthi S. K. , Fouad Emadelden , Alshomrany Ali S. , Amin A. F. , Hanafy H. 
Published: September 2024

An optical sensor based on a defective photonic crystal is proposed to identify the Chikungunya virus in blood components, including plasma, platelets, red blood cells (RBCs), and uric acid. Under healthy conditions, each blood component has a unique refractive index; this value is altered if the person is infected with the Chikungunya virus. The infected blood sample results in a deviation in the refractive index of the sample as compared to a normal sample due to the presence of the infection in the human blood. With the help of our suggested structure, this alteration can be detected, and the normal cell can be distinguished from the infected one. To simulate the results, the transfer matrix method (TMM) is applied. The sensitivity of the suggested structures loaded separately with the sample containing plasma, platelets, red blood cells, and uric acid is found to be 1411, 1352, 1335, and 795 nm/RIU, respectively. These results are enough to support our claim that the present design can be used as an ultra-sensitive nanophotonic biosensor for the detection of the Chikungunya virus.
In-network stable radix sorter using many FPGAs with high-bandwidth photonics [Invited]
Authors: Mizutani Kenji , Urino Yutaka , Shimizu Takanori , Yamaguchi Hiroshi , Nakamura Shigeru , Usuki Tatsuya , Ishii Kiyo , Matsumoto Ryosuke , Inoue Takashi , Namiki Shu , Koibuchi Michihiro 
Published: September 2024

A modern field-programmable gate array (FPGA) card can be equipped with high-bandwidth memory and high-bandwidth optical interconnection networks. This paper presents an in-network stable radix sorter on an eight-FPGA cluster. Each custom Stratix10 MX2100 FPGA card has up to 819-Gbps memory bandwidth (51.2Gbps×16channels) and up to 800-Gbps network bandwidth (25Gbps×32channels) with eight custom embedded optical modules. Our radix sorter for a 32-bit key range consists of eight 4-bit counting sorts optimized to in-network processing. Each counting sort needs only one memory read/write access for improving its throughput. We demonstrated a sorting throughput of 37.2 GB/s and an energy efficiency of 9.2 MB/J for 32-bit key range and 16-GiB data size using eight memory channels with 409.6 Gbps memory bandwidth per FPGA. It can scale up to 256 FPGAs with a sorting throughput of 983 GB/s for a 32-bit key range and 512-GiB data size.
Correlation between symptom experience and fear of cancer recurrence in postoperative breast cancer patients undergoing chemotherapy in China: A cross-sectional study
Authors: Han Manxia , Chen Huaying , Li Jialing , Zheng Xuemei , Zhang Xue , Tao Lin , Zhang Xiaoxia , Feng Xianqiong 
Published: September 2024

Objective
To analyze the relationship between experience of symptoms (e.g., pain, fatigue) and fear of cancer recurrence (FCR) in Chinese postoperative patients with breast cancer undergoing chemotherapy.

Methods
A total of 225 patients were recruited using convenience sampling. The Fear of Cancer Recurrence Inventory-Chinese Version and the Symptom Experience Index were used to collect data. The Mann–Whitney U test, Spearman’s correlation, and multivariate analysis were employed to explore the relationships between symptom experience and FCR.

Results
The total Fear of Cancer Recurrence Inventory score in postoperative patients with breast cancer undergoing chemotherapy was 43.19±22.83, and >64.0% of participants exhibited significant fear of cancer recurrence. The total score of symptom experience was 27.41±16.77, including scores of symptom severity (16.91±8.70) and symptom distress (10.50±8.89). Participants’ symptom experience was positively correlated with fear of cancer recurrence (r = 0.353, P < 0.001). Patients with clinically relevant FCR had higher scores for total symptom experience (Z = -3.911, P<0.001), symptom severity (Z = –3.245, P = 0.001), and symptom distress (Z = –4.185, P<0.001), compared to patients without clinically relevant FCR. Symptom experience (b = 0.511, t = 6.474, P<0.001), age (b = –0.591, t = –4.201, P<0.001), and educational level (b = 4.147, t = 3.955, P<0.001) were statistically correlated with FCR, accounting for 27.0% of the variance. Among these variables, symptom experience demonstrated the strongest correlation, with a beta value of 0.371.

Conclusion
This study followed others in identifying a cross-sectional relationship between symptom experience and FCR. Further prospective research is required to better understand the nature of this relationship.
Cardiovascular equity and health center funding: Associations of unmet hypertension and diabetes need by race/ethnicity and federal grants at federally qualified health centers, 2014–2019
Authors: Kishore Sanjay , Kishore Sandeep P. , Clark Cheryl , Sommers Benjamin D. 
Published: September 2024

Importance
Racial and ethnic disparities in chronic disease are a major public health priority.

Objective
To determine if the amount of federal grant funding to federally-qualified health centers (FQHCs) was associated with baseline overall prevalence of uncontrolled hypertension and uncontrolled diabetes, as well as prevalence by racial and ethnic subgroup.

Design
Cross-sectional multivariate regression analysis of Uniform Data System 2014–2019, which includes clinic-level data from each FQHC regarding demographics, chronic disease control by race and ethnicity, and grant funding.

Exposures
Our main exposure were the average values of the prevalence of uncontrolled hypertension and uncontrolled diabetes among the overall population and by racial and ethnic group from 2014–2016.

Main outcomes
Average federal grant funding per patient from 2017–2019, as measured by annual health center funding from the Bureau of Primary Health Care (BPHC) and overall federal grant funding.

Results
We analyzed 1,205 FQHCs from 2014–2019; the average BPHC grant per patient across all FQHCs in 2019 was $168 while the average total federal grant was $184 per patient. Increasing shares of total patients with uncontrolled hypertension or uncontrolled diabetes were not associated with increased total federal grant funding in either unadjusted or adjusted analysis. Increased shares of patients who are American Indian or Alaskan Native (AI-AN) with uncontrolled hypertension and diabetes were associated with increasing total federal grant funding in both unadjusted and adjusted analysis (adjusted beta hypertension $168.3, p <0.001; adjusted beta diabetes 59.44, p = 0.02). However, cardiovascular clinical need among other racial and ethnic groups was not significantly associated with grant funding.

Conclusions
FQHCs with higher overall rates of uncontrolled hypertension or diabetes do not receive more federal funds, and there is no significant association between federal funding levels and rates of uncontrolled blood pressure or diabetes within most racial and ethnic groups, with the exception of AI-AN populations. To narrow inequities in cardiovascular disease, HRSA should consider more explicitly targeting federal grants to clinics with higher levels of clinical need.