bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why Do Women Not Use Preconception Care? A Systematic Review On Barriers And Facilitators
Authors: Poels Marjolein , Koster Maria P. H. , Boeije Hennie R. , Franx Arie , van Stel Henk F. 
Published: October 2016

Importance
Preconception care (PCC) has the potential to optimize pregnancy outcomes. However, awareness of PCC among the target population is generally limited, and the use of PCC remains low.

Importance
The objective of this study was to review the literature on women's perceptions regarding barriers and facilitators for the use of PCC.

Evidence Acquisition
A systematic search was conducted in MEDLINE, Embase, CINAHL, and PsycINFO for published studies until February 2015. Original qualitative and quantitative peer-reviewed studies from Western countries in English, holding women's perceptions regarding barriers and facilitators for the use of PCC. Data extraction and analysis were performed using NVivo version 10 software. A coding frame was derived from the findings and applied by 2 authors. Thematic analysis was used to identify key topics and themes.

Results
Twenty-one good-quality articles were included, of which 10 qualitative and 11 quantitative studies. Seven main themes were identified: preconditions, emotions and beliefs, perceived need, knowledge and experience, social structure, accessibility, and provider characteristics. “Not (fully) planning pregnancy”, “perceived absence of risks”, “lack of awareness”, and “pregnancy experiences” were the most frequently identified barriers and “believing in the benefits” and “availability of PCC” the most frequently identified facilitators for PCC use.

Conclusions and Relevance
Women perceive more barriers than facilitators related to PCC uptake, which explains why the use of PCC remains low. Our results provide a starting point to refocus interventions and strategies, aiming on enlarging the awareness, perceived importance, and accessibility of PCC to improve its uptake.

Target Audience
Obstetricians and gynecologists, family physicians.

Learning Objectives
After completing this activity, the learner should be better able to (1) appraise the recent literature on barriers and facilitators that affect the uptake rates of preconception care; (2) discuss which perceptions women hold regarding the use of preconception care; and (3) take these factors into account while designing preconception care interventions and strategies.
Graft and Mesh Use in Transvaginal Prolapse Repair: A Systematic Review
Authors: Schimpf Megan O. , Abed Husam , Sanses Tatiana , White Amanda B. , Lowenstein Lior , Ward Renée M. , Sung Vivian W. , Balk Ethan M. , Murphy Miles 
Published: October 2016

(Abstracted from Obstet Gynecol 2016;128:81–91)
In 2008, the US Food and Drug Administration (FDA) issued the first safety communication regarding serious complications associated with the use of transvaginal mesh for pelvic organ prolapse (POP) repair. Since this first safety communication, there have been increasing reports of debilitating mesh complications such as erosion, chronic pain, and dyspareunia, as well as high recurrence rates.
PROSE Treatment in Atypical Ocular Graft-Versus-Host Disease
Authors: Chiu Gloria B. , Theophanous Christos , Irvine John A. 
Published: October 2016

ABSTRACT

Purpose
To report a case of persistent epithelial defects in a patient with ocular chronic graft-versus-host disease that required coordinated modulation of systemic immunosuppressive treatment and overnight wear of Prosthetic Replacement of the Ocular Surface Ecosystem (BostonSight PROSE, Needham, MA) devices to achieve ocular surface healing.

Case Report
The case of a 38-year-old male patient who presented with a 2-year history of ocular chronic graft-versus-host disease, ocular burning, pain, light sensitivity, and a 3-week history of bilateral corneal epithelial defects is presented. Standard therapies and an initial PROSE treatment utilizing customized scleral lenses were unsuccessful in resolving his ocular complications. A second trial of PROSE treatment involving overnight wear of the devices in combination with increased systemic immunosuppressant therapy ultimately allowed ocular surface healing and improved his discomfort, vision, and quality of life.

Conclusions
Sight-threatening complications of ocular chronic graft-versus-host disease often require a multidisciplinary approach. Persistent corneal epithelial defects may require increased systemic immunosuppression and extension of PROSE treatment to overnight wear.
A Prospective Study of Renal Transplant Recipients: A Fall in Insulin Secretion Underpins Dysglycemia After Renal Transplantation
Authors: Langsford David , Obeyesekere Varuni , Vogrin Sara , Teng Jessie , MacIsaac Richard J. , Ward Glenn , Alford Frank , Dwyer Karen M. 
Published: October 2016

Background
Dysglycemia (encompassing impaired glucose tolerance and diabetes mellitus) arising after renal transplantation is common and confers a significant cardiovascular mortality risk. Nonetheless, the pathophysiology of posttransplant dysglycemia is not well described. The aim of this study was to prospectively and comprehensively assess glucose handling in renal transplant recipients from before to 12 months after transplantation to determine the underpinning pathophysiology.

Materials and Methods
Intravenous and oral glucose tolerance testing was conducted before and at 3 and 12 months posttransplantation. An intravenous glucose tolerance test was also performed on day 7 posttransplantation. We followed up 16 transplant recipients for 3 months and 14 recipients for 12 months. Insulin secretion, resistance and a disposition index (DI (IV)), a measure of β cell responsiveness in the context of prevailing insulin resistance, were also determined.

Results
At 12 months, 50% of renal transplant recipients had dysglycemia. Dysglycemia was associated with a dramatic fall in DI (IV) and this loss in β cell function was evident as early as 3 months posttransplantation (23.5 pretransplant; 6.4 at 3 months and 12.2 at 12 months posttransplant). Differences in the β cell response to oral glucose challenge were evident pretransplant in those destined to develop dysglycemia posttransplant (2-hour blood glucose level 5.6 mmol/L versus 6.8 mmol/L; P < 0.01).

Conclusions
Dysglycemia after renal transplantation is common, and the loss of insulin secretion is a major contributor. Subclinical differences in glucose handling are evident pretransplant in those destined to develop dysglycemia potentially heralding a susceptible β cell which under the stressors associated with transplantation fails.
Rapid Floral and Pitcher Scent Diversification in Carnivorous Pitcher Plants (Sarraceniaceae)
Authors: Ho Winnie W. , Nathan Kutz J. , Ng Julienne , Riffell Jeffrey A. 
Published: October 2016

ABSTRACTPlant volatiles play vital roles in signaling with their insect associates. Empirical studies show that both pollinators and herbivores exert strong selective pressures on plant phenotypes. While studies often evoke the assumption that volatiles from floral and vegetative tissues are distinct due to strong pollinator-mediated selection operating on the flowers or selection from herbivores acting on the leaves, explicit tests of these assumptions are often lacking. In this study, we examined the evolution of floral and vegetative volatiles in the North American (NA) pitcher plants (Sarraceniaceae). In these taxa, insects are attracted for both pollination and prey capture, providing an ideal opportunity to understand the evolution of scent compounds across different plant organs. We collected a comprehensive dataset of floral and vegetative volatiles from across the NA Sarraceniaceae. We used multivariate analysis methods to examine whether volatile profiles are distinct between plant tissues, and investigated rates of scent evolution in these unique taxa. Our major findings revealed that (i) flowers and pitchers produced highly distinct scent profiles, consistent with the hypothesis that volatiles alleviate trade-offs due to incidental pollinator consumption; (ii) across species, floral scent separated into distinct regions of scent space, while pitchers showed little evidence of clustering – this may be due to convergence on a generalist strategy for insect capture; and (iii) rates of scent evolution depended on tissue type, suggesting that pollinators and herbivores differentially influence the evolution of chemical traits. We emphasize the need for additional functional studies to further distinguish between volatile functions.
A roadmap for a quantitative ecosystem-based environmental impact assessment
Authors: Coston-Guarini J. , Guarini J-M , Edmunds J. , Hinz Shawn , Wilson Jeff , Chauvaud L. 
Published: October 2016

ABSTRACTA new roadmap for quantitative methodologies of Environmental Impact Assessment (EIA) is proposed, using an ecosystem-based approach. EIA recommendations are currently based on case-by-case rankings, distant from statistical methodologies, and based on ecological ideas that lack proof of generality or predictive capacities. These qualitative approaches ignore process dynamics, scales of variations and interdependencies and are unable to address societal demands to link socio-economic and ecological processes (e.g.population dynamics). We propose to re-focus EIA around the systemic formulation of interactions between organisms (organized in populations and communities) and their environments but inserted within a strict statistical framework. A systemic formulation allows scenarios to be built that simulate impacts on chosen receptors. To illustrate the approach, we design a minimum ecosystem model that demonstrates non-trivial effects and complex responses to environmental changes. We suggest further that an Ecosystem-Based EIA - in which the socio-economic system is an evolving driver of the ecological one - is more promising than a socio-economic-ecological system where all variables are treated as equal. This refocuses the debate on cause-and-effect, processes, identification of essential portable variables, and a potential for quantitative comparisons between projects, which is important in cumulative effects determinations.
De novo assembly of viral quasispecies using overlap graphs
Authors: Baaijens Jasmijn A. , Zine El Aabidine Amal , Rivals Eric , Schönhuth Alexander 
Published: October 2016

AbstractA viral quasispecies, the ensemble of viral strains populating an infected person, can be highly diverse. For optimal assessment of virulence, pathogenesis and therapy selection, determining the haplotypes of the individual strains can play a key role. As many viruses are subject to high mutation and recombination rates, high-quality reference genomes are often not available at the time of a new disease outbreak. We present SAVAGE, a computational tool for reconstructing individual haplotypes of intrahost virus strains without the need for a high-quality reference genome. SAVAGE makes use of either FM-index based data structures or ad-hoc consensus reference sequence for constructing overlap graphs from patient sample data. In this overlap graph, nodes represent reads and/or contigs, while edges reflect that two reads/contigs, based on sound statistical considerations, represent identical haplotypic sequence. Following an iterative scheme, a new overlap assembly algorithm that is based on the enumeration of statistically well-calibrated groups of reads/contigs then efficiently reconstructs the individual haplotypes from this overlap graph. In benchmark experiments on simulated and on real deep coverage data, SAV-AGE drastically outperforms generic de novo assemblers as well as the only specialized de novo viral quasispecies assembler available so far. When run on ad-hoc consensus reference sequence, SAVAGE performs very favorably in comparison with state-of-the-art reference genome guided tools. We also apply SAVAGE on two deep coverage samples of patients infected by the Zika and the hepatitis C virus, respectively, which sheds light on the genetic structures of the respective viral quasispecies.
Analysis of noise mechanisms in cell size control
Authors: Modi Saurabh , Vargas-Garcia Cesar A. , Ghusinga Khem Raj , Singh Abhyudai 
Published: October 2016

AbstractAt the single-cell level, noise features in multiple ways through the inherent stochasticity of biomolecular processes, random partitioning of resources at division, and fluctuations in cellular growth rates. How these diverse noise mechanisms combine to drive variations in cell size within an isoclonal population is not well understood. To address this problem, we systematically investigate the contributions of different noise sources in well-known paradigms of cell-size control, such as the adder (division occurs after adding a fixed size from birth) and the sizer (division occurs upon reaching a size threshold). Analysis reveals that variance in cell size is most sensitive to errors in partitioning of volume among daughter cells, and not surprisingly, this process is well regulated among microbes. Moreover, depending on the dominant noise mechanism, different size control strategies (or a combination of them) provide efficient buffering of intercellular size variations. We further explore mixer models of size control, where a timer phase precedes/follows an adder, as has been proposed inCaulobacter crescentus. While mixing a timer with an adder can sometimes attenuate size variations, it invariably leads to higher-order moments growing unboundedly over time. This results in the cell size following a power-law distribution with an exponent that is inversely dependent on the noise in the timer phase. Consistent with theory, we find evidence of power-law statistics in the tail ofC. crescentuscell-size distribution, but there is a huge discrepancy in the power-law exponent as estimated from data and theory. However, the discrepancy is removed after data reveals that the size added by individual newborns from birth to division itself exhibits power-law statistics. Taken together, this study provides key insights into the role of noise mechanisms in size homeostasis, and suggests an inextricable link between timer-based models of size control and heavy-tailed cell size distributions.
Functional analysis of a biosynthetic cluster essential for production of 4-formylaminooxyvinylglycine, a germination-arrest factor fromPseudomonas fluorescensWH6
Authors: Okrent Rachel A. , Trippe Kristin M. , Maselko Maciej , Manning Viola 
Published: October 2016

ABSTRACTRhizosphere-associatedPseudomonas fluorescensWH6 produces the germination-arrest factor, 4-formylaminooxyvinylglycine (FVG). FVG has previously been shown to both arrest the germination of weedy grasses and to inhibit the growth of the bacterial plant pathogenErwinia amylovora.Very little is known about the mechanism by which FVG is produced. Although a previous study identified a region of the genome that may be involved in FVG biosynthesis, it has not yet been determined which genes within that region are sufficient and necessary for FVG production. In the current study, we explored the role of each of the putative genes encoded in that region by constructing deletion mutations. Mutant strains were assayed for their ability to produce FVG with a combination of biological assays and thin-layer chromatographic analyses. This work defined the core FVG biosynthetic gene cluster and revealed several interesting characteristics of FVG production. We determined that FVG biosynthesis requires two small open reading frames of less than 150 nucleotides and that multiple transporters have overlapping but distinct functionality. In addition, two genes in the center of the biosynthetic gene cluster are not required for FVG production, suggesting that additional products may be produced from the cluster. Transcriptional analysis indicated that at least three active promoters play a role in the expression of genes within this cluster. The results of this study enrich our knowledge regarding the diversity of mechanisms by which bacteria produce non-proteinogenic amino acids like vinylglycines.
Rethinking Skinner’s model: strategic trade-offs in products and services
Authors: Sarmiento Roberto , Thurer Matthias , Whelan Garvan 
Published: October 2016

PurposeThe purpose of this paper is to further clarify the link between the theoretical and practical/real-life implications of a seminal topic in the strategic operations management field: Wickham Skinner’s strategic trade-offs model. This will help researchers, practitioners and students to realize the “everyday life” consequences of this highly influential model.Design/methodology/approachA theoretical analysis is made of previous research dealing with the strategic trade-offs model. Building on these investigations, a Popperian approach is used to logically develop the model, and the authors demonstrate how it can be empirically tested.FindingsPrevious investigations on Skinner’s model mainly focus on trade-offs between competitive capabilities (e.g. cost, quality, delivery) at the firm level. This paper demonstrates that the implications of this model necessarily should include consideration of the strategic trade-offs between the competitive characteristics of products/services that practitioners, students and the general public can observe.Originality/valueWhile previous investigations have provided necessary clarifications, no paper has addressed the issue of the existence of strategic trade-offs between the competitive characteristics of products/services. This paper offers guidelines for researchers and practitioners on the way that the strategic trade-offs model can be conceptualized, understood and tested.
Enhancing learning effectiveness by adopting a knowledge-based usability guidelines
Authors: Chin Sylvia Ping-Ping , Tsui Eric , Lee Chien-Sing 
Published: October 2016

Purpose
– Guidelines for the design of knowledge-based e-learning usability systems are absent from the current recognized set of usability design heuristics and from an established evaluation methodology of e-learning system developments. Such systems can help Web designers and instructional designers design for different user needs and decide which properties are of a higher priority, thus meriting more design and development efforts. The authors aim to help students develop higher-order thinking skills, such as application, evaluation and syntheses of knowledge.

Design/methodology/approach
– The authors applied Merrill
'
s first principles of instruction and usability properties as pedagogical and usability design guidelines, knowledge management (KM) and hierarchical task analysis as methodological knowledge bases. The authors proposed a KM e-learning usability framework which frames our mapping of Web usability attributes to e-learning usability properties. The authors aim to investigate whether adopting Merrill
'
s first principles of instruction and usability properties as knowledge-based guidelines/design factors would help learners develop higher-order thinking skills and whether this design would result in positive technology acceptance. The authors also developed a method matrix to map the selected methods of cognitive engineering to its potential uses in the KM e-learning usability framework of this paper and mapped e-learning usability tools with components in the KM e-learning usability system.

Findings
– Findings indicated that our design effectively helped learners to demonstrate higher-order thinking skills and positive technology acceptance, promising indications toward the design and development of knowledge-based usability frameworks and systems.

Research/limitations/implications
– The sample size of this paper is small. Hence, conclusions are not generalizable at this moment.

Originality/Value
– The authors’ contributions are twofold: First, the authors proposed a KM e-learning usability framework, which frames the mapping of KM processes to e-learning principles and usability properties. Second, the authors proposed a method matrix which maps the selected methods of cognitive engineering to its potential uses in their KM e-learning usability framework. Based on these mappings and focusing on the usability properties navigation and learning support, the authors used ICT/Web2.0 tools to present/visualize information more clearly and more sensibly/manageably to students, to help trigger new knowledge and develop higher-order thinking skills, such as application, evaluation and syntheses of knowledge and articulate information from different perspectives throughout the KM life cycle.
Organizational performance through the donation and collection of interorganizational knowledge
Authors: Nodari Felipe , Oliveira Mirian , Maçada Antonio Carlos Gastaud 
Published: October 2016

Purpose– This paper aims to provide empirical evidence to support the relationship between interorganizational knowledge sharing, absorptive capacity and organizational performance, and proposes that interorganizational knowledge sharing is composed of two processes: knowledge donation and collection.Design/methodology/approach– A quantitative methodology is adopted to examine the proposed relationship between interorganizational knowledge sharing, absorptive capacity and organizational performance. The study uses survey data from 269 companies in Brazil. Structural equation modeling is applied to test the stated hypotheses and the model.Findings– The empirical findings indicate that interorganizational knowledge sharing is composed of the donation and collection of knowledge. Interorganizational knowledge collection is found to have a positive effect on interorganizational knowledge donation, while collection is found to have a positive effect, mediated by absorptive capacity, on organizational performance.Research limitations/implications– One limitation of this research was the predominant participation of smaller companies. Another is that the data were only collected from Brazilian companies. Moreover, an instrument to measure these constructs was proposed and validated to enable future research to be conducted into the process of interorganizational knowledge sharing and its components: knowledge donation and knowledge collection.Practical implications– Managers can enhance organizational performance by developing both the donation and collection of knowledge. Knowledge donation is particularly important because, in addition to its impact on absorptive capacity and organizational performance, it contributes to the development of knowledge collection, which is also indirectly related to performance.Originality value– The donation and collection of knowledge were validated as components of the interorganizational knowledge-sharing process, and the relationship between these processes and organizational performance is mediated by the absorptive capacity of the organization.