bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delhi’s Education Revolution
Authors: Aiyar Yamini 
Published: October 2024

Abstract
This chapter details the Delhi reform effort as observed by the study team. It draws on the participant and classroom observations, analysis of government circulars, interviews with key reformers, and other secondary sources to describe the roll out of the Delhi government’s reform efforts. The description focuses specifically on the classroom-based learning-oriented, pedagogical reform interventions called Chunauti and Mission Buniyaad. It also presents details other linked efforts like the mentor teachers, the Happiness Curriculum and the changes in the assessment structure. During the rollout, researchers were embedded in schools and training centers to capture the immediate reactions and perspectives of school level stakeholders as they struggled to make sense of what was demanded of them. Thus this chapter is able to offer a birds eye view of the early phase of the rollout of the reform from the perspective of the stakeholders. The effort is to present to the reader a realistic account of the challenges that frontline actors and reformers alike encounter when rolling out disruptive ideas in entrenched, low-state capacity organizations.
Associations between changes in deprivation and alcohol use disorder: a nationwide longitudinal study
Authors: Kim Dan Bi , Lim Jae Hyeok , Ko Ji Su , Joo Min Jeong , Park Eun-Cheol , Jang Suk-yong 
Published: October 2024

Abstract

Background
Despite conflicting findings on the association between socioeconomic status and drinking, little is known about the impact of deprivation as a measure of inequality on alcohol use disorders (AUDs).

Methods
We used the Korea Welfare Panel Study, a longitudinal survey conducted from 2012 to 2022, and included 1569 Korean adult participants. Deprivation (at least one including food, housing, medical, educational, and credit deprivation) was measured by self-report and divided into four categories according to the change in deprivation experience from the previous year to the following year. AUD was measured using the Korean version of the Alcohol Use Disorders Identification Test scale. Multivariable logistic regression was used to estimate odds ratios and 95% confidence intervals and adjusted for confounders.

Results
Among 1569 participants, worsened deprivation and consistent deprivation were positively associated with AUD compared to non-deprivation. In particular, worsened deprivation was more likely to be associated with AUD in participants with low household income, high school education level, and economic activity.

Conclusion
We found that worsened deprivation and consistent deprivation were associated with AUD. Deprivation should be considered as a health policy intervention to improve drinking problems.
Measurements of dust and respirable crystalline silica during indoor demolition and renovation
Authors: Halvorsen Johanne Ø , Graff Pål , Gjengedal Elin Lovise Folven , Ervik Torunn K 
Published: October 2024

Abstract
Increased focus on renovating and maintaining the existing building stock is an integral part of the circular economy, however this might pose challenges to workers health. The aim of this study was to assess the renovation workers’ exposure to inhalable dust, thoracic dust, respirable dust, and respirable crystalline silica (RCS). Personal aerosol samples were collected as full shift samples from 92 workers to a total of 407 samples. Fourteen locations around Oslo, Norway was visited for multiple days with repeated measurements of the same individual. Particulate matter from 3 aerosol fractions, respirable, thoracic, and inhalable, were analyzed gravimetrically, and the respirable fraction was analyzed for RCS by NIOSH 7500 method for X-ray diffraction (XRD) with low temperature plasma ashing sample preparation. The total measured concentrations of respirable dust (n = 192) had a geometric mean (GM) of 0.88 mg/m3, RCS concentrations (n = 182) had a GM of 0.040 mg/m3, thoracic dust (n = 131) had GM 2.4 mg/m3, and inhalable dust (n = 84) had a GM of 8.5 mg/m3. The maximum measured concentrations were 29 mg/m3, 3.2 mg/m3, 65 mg/m3, and 163 mg/m3, respectively. Workdays involving tasks such as mechanical demolition and clearing out demolished materials led to the highest exposure levels of both dust and RCS. However, other workers at the renovation sites were indirectly exposed to a considerable amount of RCS. This study revealed substantial exposure to both RCS and dust during renovation, and protective measures are warranted to reduce exposure levels in the industry.
Utilization of Artificial Intelligence to Improve Equitable Healthcare Access for Breast Implant Patients
Authors: Ragsdale Louisa B , Kareh Aurora M , Gupta Rohun , Firouzbakht Peter K , Plikaitis Christina M , Rodby Katherine A 
Published: October 2024

Abstract
Recently, mandated FDA patient decision checklists were developed with the goal of improving the informed decision-making process for patients considering breast implants. However, these checklists are written at reading levels far higher than recommended by the National Institutes of Health and the American Medical Association. This study aims to improve the accessibility, and therefore, the utility of the mandated FDA patient literature for the average breast implant patient using the assistance of artificial intelligence (AI). Patient decision checklists were obtained from the 3 most utilized breast implant manufacturers in the United States—Allergan, Mentor, and Sientra. A novel patient decision checklist was synthesized by AI, written at the sixth grade reading level, using these checklists as source material. The AI-assisted checklist was edited by plastic surgeons for both formatting and content. The overall readability of Allergan, Mentor, and Sientra patient checklists correlated with the college reading level. These documents were of a statistically significantly higher reading level than the AI-assisted checklist, which was written at the recommended sixth grade level. Text composition analysis similarly demonstrated substantial differences between the AI-assisted and FDA-mandated literature. The currently mandated breast implant patient checklists are written at a college reading level and are inaccessible to the average patient. The authors propose a new patient decision checklist, generated with the assistance of AI, to improve healthcare access within plastic surgery. This simplified material can be used as an adjunct to the current checklists to improve shared decision making.
ProCogGraph: a graph-based mapping of cognate ligand domain interactions
Authors: Crown Matthew , Bashton Matthew 
Published: October 2024

Abstract

Motivation
Mappings of domain-cognate ligand interactions can enhance our understanding of the core concepts of evolution and be used to aid docking and protein design. Since the last available cognate-ligand domain database was released, the PDB has grown significantly and new tools are available for measuring similarity and determining contacts.

Results
We present ProCogGraph, a graph database of cognate-ligand domain mappings in PDB structures. Building upon the work of the predecessor database, PROCOGNATE, we use data-driven approaches to develop thresholds and interaction modes. We explore new aspects of domain-cognate ligand interactions, including the chemical similarity of bound cognate ligands and how domain combinations influence cognate ligand binding. Finally, we use the graph to add specificity to partial EC IDs, showing that ProCogGraph can complete partial annotations systematically through assigned cognate ligands.

Availability and implementation
The ProCogGraph pipeline, database and flat files are available at https://github.com/bashton-lab/ProCogGraph and https://doi.org/10.5281/zenodo.13165851.
Improving bioinformatics software quality through teamwork
Authors: Ferenc Katalin , Rauluseviciute Ieva , Hovan Ladislav , Kumar Vipin , Kuijjer Marieke L , Mathelier Anthony 
Published: October 2024

Abstract

Summary
Since high-throughput techniques became a staple in biological science laboratories, computational algorithms, and scientific software have boomed. However, the development of bioinformatics software usually lacks software development quality standards. The resulting software code is hard to test, reuse, and maintain. We believe that the root of inefficiency in implementing the best software development practices in academic settings is the individualistic approach, which has traditionally been the norm for recognizing scientific achievements and, by extension, for developing specialized software. Software development is a collective effort in most software-heavy endeavors. Indeed, the literature suggests teamwork directly impacts code quality through knowledge sharing, collective software development, and established coding standards. In our computational biology research groups, we sustainably involve all group members in learning, sharing, and discussing software development while maintaining the personal ownership of research projects and related software products. We found that group members involved in this endeavor improved their coding skills, became more efficient bioinformaticians, and obtained detailed knowledge about their peers’ work, triggering new collaborative projects. We strongly advocate for improving software development culture within bioinformatics through collective effort in computational biology groups or institutes with three or more bioinformaticians.

Availability and implementation
Additional information and guidance on how to get started is available at https://ferenckata.github.io/ImprovingSoftwareTogether.github.io/.
Deucravacitinib, an oral selective allosteric tyrosine kinase 2 inhibitor, in patients from China mainland, Taiwan and South Korea with moderate-to-severe plaque psoriasis: a phase III randomized clinical trial
Authors: Zhang Jianzhong , Ding Yangfeng , Wang Ping , Li Linfeng , Pan Weili , Lu Yan , Cheng Hao , Jiang Xian , Ho Ji-Chen , Guo Shuping , Liu Leona , Chatterjee Arkendu , Kisa Renata M , Banerjee Subhashis 
Published: October 2024

Abstract

Background
Deucravacitinib, an oral selective allosteric tyrosine kinase 2 inhibitor, is approved in the USA, the European Union, Japan, South Korea, China and other countries for the treatment of moderate-to-severe plaque psoriasis.

Objectives
To evaluate the efficacy and safety of deucravacitinib in Asian patients with moderate-to-severe plaque psoriasis.

Methods
In the 52-week blinded phase III POETYK PSO-3 trial (NCT04167462), patients were randomized 1 : 2 to placebo (n = 74) or deucravacitinib 6 mg once daily (n = 146) for 16 weeks followed by deucravacitinib alone. Co-primary endpoints were the achievement of a ≥75% reduction from baseline in Psoriasis Area and Severity Index (PASI 75) and static Physician Global Assessment score of 0 (clear) or 1 (almost clear; sPGA 0/1) at week 16. Efficacy and safety were evaluated throughout.

Results
At week 16, significantly higher proportions of patients receiving deucravacitinib compared with placebo achieved PASI 75 (68.8% vs. 8.1%; P &lt; 0.001) and sPGA 0/1 (55.6% vs. 6.8%; P &lt; 0.001). Response rates with deucravacitinib were maintained through week 52. Common adverse events (AEs) included upper respiratory tract infection and nasopharyngitis. Serious AE and discontinuation rates were low.

Conclusions
Deucravacitinib was efficacious and well tolerated in Asian patients with moderate-to-severe plaque psoriasis.
Quality assessment in bone densitometry: a case of incorrect hip analysis
Authors: Xu Hongmin , Gabriel Medhat Sam , James Judy Rose 
Published: October 2024

Abstract
Dual-energy X-ray absorptiometry (DXA) is a sophisticated imaging technique utilized in the field of medical diagnostics to measure bone mineral density. The significance of DXA lies in its ability to accurately assess bone health, which is crucial in the evaluation of osteoporosis, a condition characterized by weakened bones and heightened susceptibility to fractures. Despite its widespread adoption and clinical utility, DXA is not without limitations. Factors such as body size, tissue hydration, the presence of metal implants, improper equipment installation and maintenance, as well as inadequate education and training in bone densitometry may influence DXA measurements, necessitating careful interpretation by trained professionals. We present a case to show the errors that occurred during DXA analysis leading to dramatic T-score changes, highlighting the importance of technologists’ adherence to manufacturers’ recommendations, to ensure the accurate processing of DXA scans and diagnosis.
Expression of sPD-L1 levels in an ex vivo liver perfusion model
Authors: Irsara Christian , Weissenbacher Annemarie , Krendl Felix Julius , Anliker Markus , Hofmann Julia , Hautz Theresa , Schneeberger Stefan , Griesmacher Andrea , Loacker Lorin 
Published: October 2024

Abstract
The programmed cell death protein 1 (PD-1) acts as a central inhibitory immune checkpoint receptor. The soluble form of its primary ligand, sPD-L1, was found to be elevated in the serum of patients with cancer, infectious diseases, and chronic inflammation. So far, the hepatic origin of sPD-L1 has received relatively little attention and is therefore the subject of this study in the context of normothermic machine perfusion (NMP) of liver grafts. sPD-L1 concentrations as well as several well-established clinically relevant laboratory parameters were determined in the perfusate of 16 donor liver grafts undergoing NMP up to 30 hours. sPD-L1 levels continuously increased during NMP and significantly correlated with markers of hepatic synthesis (cholinesterase), acute-phase proteins (von Willebrand factor, procalcitonin, antithrombin, interleukin-6, fibrinogen), and liver decay markers (gamma-glutamyltransferase, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase). Perfusate leukocytes were in the lower reference range and decreased after 12 hours. Mean sPD-L1 levels in the perfusate correlated with donor levels of gamma-glutamyltransferase, alanine aminotransferase, creatinine, and blood urea nitrogen. Our study reveals a significant increase in the concentration of sPD-L1 following ischemia-reperfusion injury in a hepatic ex vivo model. sPD-L1 concentrations during NMP correlate with established acute-phase proteins and liver cell decay markers, suggesting that hepatic sPD-L1 synthesis or shedding increases during the acute phase and cell decay. Furthermore, sPD-L1 correlates with established liver function and synthesis parameters as well as with donor laboratory values and might therefore be a potential biomarker for the hepatic function of liver grafts.
Real-World Treatment Outcomes Associated With Early Versus Delayed Vedolizumab Initiation in Patients With Ulcerative Colitis
Authors: Krugliak Cleveland Noa , Candela Ninfa , Carter John A , Kuharic Maja , Qian Joyce , Tang Zhaoli , Turpin Robin , Rubin David T 
Published: October 2024

Abstract

Background
Patients with ulcerative colitis (UC) typically receive a targeted inflammatory bowel disease therapy after treatment with conventional therapies and after the development of significant morbidity. Evidence suggests that early biologic treatment after diagnosis could improve treatment response and prevent disease complications compared with delayed biologic treatment after conventional therapy.

Methods
RALEE was a retrospective study using claims data from IBM® MarketScan® Research Databases between January 1, 2016 and December 31, 2019. Adults with UC and at least one claim for vedolizumab were categorized into Early or Delayed Vedolizumab groups according to whether they had received vedolizumab within 30 days of diagnosis or after conventional therapy (5-aminosalicylates, corticosteroids, and immunomodulators), respectively. Treatment response was assessed at 2, 6, and 12 months after vedolizumab treatment initiation and was analyzed with logistic regression (bivariate).

Results
At 2 months, Delayed Vedolizumab was associated with significantly higher odds of nonresponse than Early Vedolizumab (odds ratio [OR], 2.509; 95% confidence interval [CI], 1.28-4.90). Delayed Vedolizumab was not significantly associated with odds of nonresponse at 6 months (OR, 1.173; 95% CI, 0.72-1.90) or at 12 months (OR, 0.872; 95% CI, 0.55-1.37). Mean total healthcare costs were similar in the Early Vedolizumab ($6492) and Delayed Vedolizumab ($5897) groups, although there were small differences in costs from different types of claims.

Conclusions
Patients who received vedolizumab early after UC diagnosis were less likely to experience nonresponse at 2 months and incurred similar healthcare costs at 12 months compared with patients who received delayed vedolizumab.
Successful treatment of atrial flutter post-radiofrequency ablation for atrial fibrillation following atrial septal defect occlusion: a case report of pulsed field ablation
Authors: Hu Jing , Ding Ligang , Gunawan Evan , Lai Hengli , Yao Yan 
Published: October 2024

Abstract

Background
Atrial flutter (AFL) is a common arrhythmia following radiofrequency ablation (RFA) for atrial fibrillation (AF), with varying incidence depending on the ablation strategy. Patients with prior atrial septal defect (ASD) occlusion pose challenges for ablation, particularly when the lesions are located near the occluder. Pulsed field ablation (PFA) has emerged as a promising alternative to RFA for the treatment of AF or AFL; however, its use in patients with ASD occlusion remains unexplored.

Case summary
We present the case of a 46-year-old female with a history of ASD occlusion and subsequent RFA for AF. Despite the initial success, she developed symptomatic AFL 3 months post-procedure. Intracardiac echocardiography (ICE)–guided transseptal puncture guided by ICE revealed an AFL originating from the slow conduction area around the ASD occluder. Pulsed field ablation was successfully performed, and AFL was terminated without complications. Post-procedural follow-up demonstrated maintenance of sinus rhythm.

Discussion
Patients with ASD occlusion present unique challenges for ablation, including difficulties in transseptal puncture and risk of injury to the occluder. Pulsed field ablation offers a potential solution, with studies showing fewer reconnected pulmonary veins and larger lesion creation compared with traditional methods. In our case, PFA effectively terminated the refractory AFL, highlighting its utility in this patient population. Moreover, the use of the Jinjiang PFA catheter with pulse circuit self-checking technology ensured procedural safety, particularly near the occluder.
Use of suture-mediated closure device system after inadvertent medport placement in the subclavian artery leading to multi-focal ischaemic infarct: a case report
Authors: Rodríguez-Santiago María A , Rodríguez-Cruz Edwin , Mesa-Pabon Marcel A 
Published: October 2024

Abstract

Background
Totally implantable venous access devices or chemoports are progressively being used in oncologic patients for long-term chemotherapy administration. We present the case of an iatrogenic arterial catheter placement in the aortic arch complicated with multi-focal ischaemic stroke.

Case summary
A case of a 73-year-old woman with a history of hypertension, diabetes mellitus, pineal gland tumour status post ventriculoperitoneal shunt, and breast and bladder cancer presented with a 2-week history of impaired balance, dysarthria, and right-sided facial drop. The chemoport was placed less than a month prior to the onset of symptoms at another institution. A brain magnetic resonance imaging revealed a left hemispheric supra- and infra-tentorial subacute ischaemic infarcts. The head and neck computed tomography angiography notably showed a misplaced venous port at the left subclavian artery with a distal tip projecting towards the ascending aortic arch, revealing the most likely aetiology of multi-focal ischaemic stroke. The patient underwent successful subclavian artery catheter extraction and endovascular repair with a suture-mediated closure device system without complications.

Discussion
Subclavian artery iatrogenic cannulation may lead to catastrophic outcomes, including stroke. A high level of suspicion for venous port misplacement must be entertained when ipsilateral multi-focal ischaemic infarct occurs in time relation to catheter placement. Conducting an endovascular catheter retrieval and using a suture-mediated closure device is an alternative approach to manual compression in locations where achieving an haemostasis is challenging. A suture-mediated closure device system might be useful for anatomy not amenable to manual compression, such as the subclavian artery.
Side branch preservation using tip detection-antegrade dissection re-entry after failed subintimal tracking and re-entry in chronic total occlusion: a case report
Authors: Dwiputra Bambang , Tadano Yutaka , Sugie Takuro , Fujita Tsutomu 
Published: October 2024

Abstract

Background
Techniques for treating difficult chronic total occlusions (CTOs) have evolved with the discovery of the tip detection-antegrade dissection re-entry (TDADR) guided by intravascular ultrasound (IVUS). This case demonstrates TDADR as a viable bailout in failed subintimal tracking and re-entry (STAR) technique.

Case summary
A 78-year-old man with stable angina on optimal medical therapy had exertional angina pectoris secondary to a residual CTO lesion of the left circumflex coronary (LCX) artery. Percutaneous coronary intervention was performed for a mid-LCX CTO with a blunt proximal stump where the dissection plane expanded along the main vessel and side branch 2. Due to lack of promising collaterals for the retrograde approach, STAR successfully recanalized side branch 1. As main vessel failed to be recanalized, we proceeded with an AnteOwl IVUS-guided TDADR, intending guidewire penetration into the true lumen from the middle of the dissection plane at the main vessel, proximal to side branch 2 origin. Accurate wiring was achieved, and a guidewire was placed on side branch 2 for protection. After stent placement in the main vessel and kissing inflation, cutting balloon dilatation was performed to create re-entries for the STAR-induced extended main vessel haematoma. The procedure resulted in complete revascularization of main vessel and side branches. At 12-month follow-up, no further angina was reported, and coronary computed tomography showed patent side branches with no significant in-stent restenosis.

Discussion
Imaging-based TDADR method was effective in our present case despite failed STAR technique. Limited IVUS and operator availability may become a barrier in implementing TDADR.
Public Good Superstars: A Lab-in-the-Field Study of Wikipedia
Authors: Hergueux Jérôme , Algan Yann , Benkler Yochai , Fuster-Morell Mayo 
Published: October 2024

Abstract
Many field public goods are provided by a small number of contributors: the ‘superstars’ of their respective communities. This paper focuses on Wikipedia, one of the largest online volunteering platforms. Over nine consecutive years, we study the relationship between social preferences—reciprocity, altruism and social image—and field cooperation. Wikipedia editors are quite prosocial on average, and superstars even more so. But while reciprocal and social image preferences strongly relate to contribution quantity among casual editors, only social image concerns continue to predict differences in contribution levels between superstars. In addition, we find that social image–driven editors—both casual and superstars—contribute lower-quality content on average. Evidence points to a perverse social incentive effect, as quantity is more readily observable than quality on Wikipedia.