bluuebunny/crossref_metadata_2025_split huggingface dataset:
ВПЛИВ КОМПЛЕКСНИХ ЛІКУВАЛЬНО-ПРОФІЛАКТИЧНИХ ЗАХОДІВ НА СТАН ЙОДНОГО ЗАБЕЗПЕЧЕННЯ, ГІПОФІЗАРНО-ТИРЕОЇДНУ СИСТЕМУ В ЖІНОК ІЗ ПРЕЕКЛАМПСІЄЮ В ПОЄДНАННІ З ГІПОТИРЕОЗОМ.
Authors: Fedynchuk H. V. , Maliar V. V. , Maliar V. A. 
Published: May 2016

<p>Обстежено 100 вагітних жінок із прееклампсією на тлі йододефіцитних захворювань у регіоні з природною нестачею йоду Закарпаття, у яких проводилася традиційна терапія та розроблена комплексна терапія, яка включала комбінацію йодовмісного та вітамінно-оксидного комплексу (тріовіт); препаратів, що покращують мікроциркуляцію матково-плацентарного комплексу (актовегін); корекція гомеостазу проводилася включенням аспірину. При ключенні до традиційної терапії комплексного препарату, до складу якого входять йодид калію (770 мкг), вітаміни А і D2 та омега-3 поліненасичені кислоти, загальна медіана йодурії (Ме) у вагітних зросла у 1,4 раза, що забезпечило ліквідацію йододефіциту. Про ефективність запропонованої технології ведення вагітності свідчить зниження частоти фетоплацентарної недостатності та зміни її структури, що привело до зниження рівня передчасних пологів, анемії, розвитку важких форм прееклампсії.<br /><br /></p>
МОРФОЛОГІЧНА ХАРАКТЕРИСТИКА ГІПЕРПЛАСТИЧНИХ ПРОЦЕСІВ ЕНДОМЕТРІЯ ЗА УМОВ ПОЛІМОРБІДНОСТІ У ЖІНОК РЕПРОДУКТИВНОГО ВІКУ, ЩО ПРОЖИВАЮТЬ НА ЙОДОДЕФІЦИТНІЙ ТЕРИТОРІЇ.
Authors: Chornenka H. M. 
Published: May 2016

<p>На основі ретроспективного аналізу 100 історій хвороб жінок репродуктивного віку, які перебували на стаціонарному лікуванні з приводу метрорагії, наведено структуру гіперпластичних процесів ендометрія за умов поліморбідності. З’ясовано, що варіанти гіперпластичного<br />ремоделювання ендометрія мають залежність від наявності супутніх соматичних розладів, у т. ч. дисфункції итоподібної<br />залози. У структурі гіперпластичного ремоделювання гістологічно переважно діагностується залозиста гіперплазія<br />ендометрія і поліпи ендометрія, рідше атипова залозиста гіперплазія і аденокарцинома. Гістологічна структура поліпів<br />має свої особливості, які проявляються втратою координації стромально-залозистого відношення та зміною ядерноцитоплазматичного індексу епітеліоцитів.<br /><br /></p>
ПРОБЛЕМНО–ОРІЄНТОВАНА ОСВІТА
Authors: Pokanevych O. V. , Matyash M. М. , Khudenko L. I. 
Published: May 2016

<p>В статті, з метою ефективної інтеграції в Європейський освітній простір, окреслені проблеми сучасної освіти в Україні. Визначено, що ефективне професійне формування студента медичного університету можливе з врахуванням характерологічних, етнокультуральних особливостей особистості та є невідривним від розвитку країни.</p>
Pattern and Prognostic Implications of Cardiac Metastases Among Patients With Advanced Systemic Cancer Assessed With Cardiac Magnetic Resonance Imaging
Authors: Pun Shawn C. , Plodkowski Andrew , Matasar Matthew J. , Lakhman Yulia , Halpenny Darragh F. , Gupta Dipti , Moskowitz Chaya , Kim Jiwon , Steingart Richard , Weinsaft Jonathan W. 
Published: May 2016

Background

Cardiac magnetic resonance (
CMR
) imaging is well validated for tissue characterization of cardiac masses but has not been applied to study pattern and prognostic implications of cardiac metastases (
CMETs
) among patients with systemic cancer.

Methods and Results

The population consisted of 60 patients with stage
IV
cancer (32 patients with CMETs, 28 diagnosis‐matched controls) undergoing
CMR
.
CMET
was defined as a discrete mass with vascular tissue properties on delayed enhancement
CMR
. CMET‐positive patients and controls had similar clinical characteristics, cardiac geometry, and function (
P
=
NS
). Leading cancer types associated with
CMET
were sarcoma, melanoma, and gastrointestinal. Patients with
CMET
s had similar distribution of extracardiac metastatic disease compared with controls (organs involved: 3.4±2.0 versus 2.7±1.9,
P
=0.17). In 94% of patients with CMETs, there were metastases involving ≥1 extracardiac organ (66% lung involvement).
CMET
location varied (right ventricle 44%, right atrium 19%, left ventricle 28%, left atrium 9%, pericardial 25%); 22% of cases had multichamber involvement. Right‐sided chamber involvement was common in hematologic/lymphatic spread (67%); pericardial involvement was common with direct spread (64%). Regarding tissue properties on delayed enhancement
CMR
,
CMET
s commonly (59%) demonstrated heterogeneous enhancement (41% diffuse enhancement). Heterogeneous lesions were larger and had increased border irregularity (
P
<0.05). Survival 6 months post‐
CMR
was numerically lower among patients with
CMETs
(56% [95%
CI
39–74%]) versus stage
IV
cancer–matched controls (68% [95%
CI
50–86%]), although differences between groups were nonsignificant (
P
=0.42).

Conclusions

CMETs
vary regarding etiology, location, and tissue properties on
CMR
, highlighting need for comprehensive surveillance of cardiac involvement regardless of cancer origin. Prognosis remains poor with for patients with CMETs, albeit similar to that for stage
IV
cancer controls matched for cancer etiology.
Blackflies (Diptera: Simuliidae) in Croatia: species richness, distribution and relationship to surrounding countries
Authors: IVKOVIĆ MARIJA , KÚDELA MATUŠ , KÚDELOVÁ TATIANA 
Published: May 2016

All records of blackflies (Simuliidae) from the territory of Croatia are summarized, including previously unpublished data. The blackfly fauna of Croatia consists of 28 species. Simulium (Nevermannia) angustitarse (Lundström), Simulium (Nevermannia) cryophilum (Rubtsov) complex, Simulium (Nevermannia) lundstromi (Enderlein), Simulium (Nevermannia) vernum Macquart complex, Simulium (Simulium) argyreatum Meigen, Simulium (Simulium) bezzii (Corti) complex, Simulium paraequinum Puri and Simulium pseudequinum Séguy are reported for the first time from Croatia. Information related to the ecoregions, in which species were found and specific species traits are given. Genus Prosimulium Roubaud is represented by one species only. Genus Simulium Latreille is represented by 27 species in six subgenera, with subgenus Simulium Latreille s. str. being most species rich (13 species) and subgenera Boophthora Enderlein and Trichodagmia Enderlein represented each by only one species. Compared to the neighboring countries, the Croatian species assemblage is most similar to the fauna of Slovenia and least similar to that of Italy. The relatively low number of species, presence of several species complexes and unclear identity of other species show that further research of blackflies in Croatia is needed.
Impulsivity and attentional bias as predictors of modafinil treatment outcome for retention and drug use in crack-cocaine dependent patients: Results of a randomised controlled trial
Authors: Nuijten Mascha , Blanken Peter , Van den Brink Wim , Goudriaan Anna E , Hendriks Vincent M 
Published: May 2016

Background: High impulsivity and attentional bias are common in cocaine-dependent patients and predict poor treatment outcomes. The pharmacological agent modafinil is studied for its cognitive-enhancing capacities and may therefore improve clinical outcomes in crack-cocaine dependent patients. In this study, we investigated first whether pre-treatment impulsivity and attentional bias predict treatment outcome; next whether the drug modafinil given as an add-on treatment to cognitive behavioural therapy (CBT) improves impulsivity and attentional bias; and last, whether changes in impulsivity and attentional bias are related to improvements in treatment outcome. Methods: Crack-cocaine dependent outpatients ( n = 65) were randomised to 12 weeks CBT plus modafinil (400 mg/day) or only CBT. Self-reported impulsivity was assessed at baseline using the Barratt Impulsiveness Scale. At baseline and Week 12, we assessed inhibitory control as a behavioural measure of impulsivity, in terms of cognitive interference (Stroop task) and response inhibition (‘stop-signal task’), and attentional bias with the addiction Stroop task. Clinical outcomes were CBT-retention and crack-cocaine use. Results: At baseline, self-reported impulsivity predicted better CBT-retention; low self-reported and behavioural impulsivity and attentional bias predicted less crack-cocaine use. Changes in cognitive performance were not modafinil-related, but most likely due to low adherence. Improvements in impulsivity or attentional bias were not associated with CBT-retention nor changes in crack-cocaine use. Conclusions: Baseline impulsivity and attentional bias predicted clinical outcomes in crack-cocaine dependent patients. There were no firm indications that modafinil reduced impulsivity nor attentional bias in this population. Future studies involving cognitive-enhancing medications should include strategies to optimise adherence, to be better able to evaluate their potential.
Fumaric acid ester treatment in cutaneous lupus erythematosus (CLE): a prospective, open-label, phase II pilot study
Authors: Kuhn A , Landmann A , Patsinakidis N , Ruland V , Nozinic S , Perusquía Ortiz A M , Sauerland C , Luger T , Tsianakas A , Bonsmann G 
Published: May 2016

Objective The aim of the study was to assess the efficacy and safety of fumaric acid esters (FAEs) in patients with cutaneous lupus erythematosus (CLE). Methods In this 24-week, prospective, open-label, phase II pilot study, 11 patients with CLE, refractory to topical corticosteroids, were included. The primary endpoint of the study was the evaluation of the efficacy of FAEs after 24 weeks of treatment as assessed by the Revised Cutaneous Lupus Disease Area and Severity Index (RCLASI). Results Compared to baseline, significant improvement in the mean total RCLASI activity score and the mean RCLASI activity score for skin lesions was observed in week 12 ( p = 0.002, p = 0.002, respectively) and in week 24 ( p = 0.009, p = 0.009, respectively). Most common adverse events included abdominal cramps and headache. Conclusions FAEs could be an alternative and safe treatment in patients with therapy-refractory CLE; however, randomized controlled trials are warranted to evaluate the efficacy and safety of FAEs in this disease.
Whither are the Tribals in Chhattisgarh…
Authors: Saxena Anupama , Ganveer Dhammshil 
Published: May 2016

According to the Census of India Report of 2011, majorihJ of the tribal population is concentrated in cwtral part of India coupled with overwhelming availabilihj of natural resources particularly in the state of Chhattisgarl! and Madhya Pradesh. These tribal people who are indigenous to India have remained backward, oppressed and exploited in terms of their political participation and socio-economic conditions compared to the general class in the sociehj, despite the constitutional safeguards and clusters of policies framed by the state and central government. This paper seeks to provide a review of the stahls of Tribals in Chhattisgarh state. Statistical comparison on various socio-economic indicators, with the parent state Madhya Pradesh have also been made.
Turning the Wheel
Authors: Sarangi Jaydeep 
Published: May 2016

Dalit writers have employed diverse literary strategies to counter the stereotypical position of being victims of oppression. This act of authoring proves to be reformatory act for their social identity and dalit‐hood. Dalit Literary Movements are acts of liberation. Bengali dalit writers put forward fervent plea for a complete overhaul of society by questioning prevailing practices of caste and class in different parts of India. Manohar Mouli Biswas is a flag bearer of the dalit literary movement in Bengal. Biswas writes for a casteless and classless society, based on human values of justice, equality and fraternity, which is to be attained through a cultural, primarily literary movement. “‘Why do you play with that boy? Is there no one else in the whole village to play with? Don‐t give him water in that vessel. If he touches it, he'll defile it. Go away.' I was upset because I couldn't give water to a friend. Is one's caste more important than one's friend? Is caste more important than thirst? Wasn't Arjya a human being? If so, how could he make water impure by merely touching it?” (Limbale 2003:20)
Prevention of Divorce-Related Problems in Dutch 4- to 8-Year-Olds
Authors: Klein Velderman Mariska , Pannebakker Fieke D. , van Vliet Wendy , Reijneveld Sijmen A. 
Published: May 2016

Objective: Parental divorce has strong impacts on children. Evidence-based programs to support young children after parental divorce are rare. The U.S.-developed Children of Divorce Intervention Program (CODIP) is one of these. CODIP’s effectiveness outside the U.S. setting is to be further replicated. This study aimed at cultural adaptation of CODIP for Dutch 4- to 8-year-olds, evaluation of the feasibility of adapted CODIP-Netherlands modules (CODIP-NL) in the Dutch setting, and comparison with U.S. results. Methods: A pilot study ( N = 43) was conducted, comprising nine CODIP-NL groups. Results: Results showed intermediate and end users to be satisfied. Outcomes improved regarding mother-, teacher-, and group leader–reported child functioning. Standardized effect estimates were smaller than those found in the United States. Conclusions: CODIP-NL seems to be a feasible and satisfactory method to reduce divorce-related problems in Dutch 4- to 8-year-olds. This study could provide guidance to researchers interested in adapting research-based interventions to different cultural settings.
Single-Dose Fluconazole Therapy for Oral Thrush in Hospice and Palliative Medicine Patients
Authors: Lagman Ruth , Davis Mellar , LeGrand Susan , Walsh Declan , Parala Armida , Gamier Pamela , Cothren Brenda , Cheema Bushra , Gopal Sumi , Rybicki Lisa 
Published: May 2016

Background: Oral thrush is a common fungal infection of the mouth experienced by palliative medicine and hospice patients who have advanced cancer. Individuals often experience distressing symptoms that affect their oral intake with most regimens adding to pill burden. This is an open-label prospective observational study to assess the efficacy of a single-dose fluconazole 150 mg for oral thrush. Methods: Palliative medicine and hospice patients with a clinical diagnosis of oral thrush, a life expectancy of more than 1 week, and were able to swallow were enrolled. Signs and symptoms were evaluated on day 1 prior to administration of 150 mg of fluconazole and between days 3 to 5 after treatment. Results: Of 57 patients, 55 (96.5%) had more than 50% improvement in signs and symptoms. Both the number and severity of symptoms changed significantly posttreatment ( P < .001). Side effects were few. Conclusion: Single-dose fluconazole 150 mg is an effective treatment of oral thrush for individuals with advanced cancer.
Nodular Subtype of Bullous Pemphigoid
Authors: Dangel Björn , Kofler Lukas , Metzler Gisela 
Published: May 2016

Introduction: Itching nodules and papules are common findings. A rare but important differential diagnosis is the nodular subtype of bullous pemphigoid. Methods and Results: The investigators report a female patient presenting with strongly itching papules disseminated over her extremities and trunk. Physical examination revealed multiple erythematous, mostly excoriated papules and nodules on her back, abdomen, and extremities. Histology showed changes compatible with prurigo lesion, and immunofluorescence showed positive results for BP180 and BP230. Considering these clinical, histologic, and immunofluorescence findings, the diagnosis of a nodular subtype of bullous pemphigoid was made. The patient showed healing of lesions under a combination therapy with systemic psoralen and ultraviolet A, topical application of corticosteroids, and systemic therapy with azathioprine and prednisolone. Discussion: Pemphigoid nodularis represents the rare prurigo variant of bullous pemphigoid. Typically, lesions show the same immunopathologic and histologic features as in common bullous pemphigoid but mostly without the characteristic clinical finding of bullae.
Assessment and Development of Global Leadership Competencies in the Workplace
Authors: Cumberland Denise M. , Herd Ann , Alagaraja Meera , Kerrick Sharon A. 
Published: May 2016

The Problem In the 21st century, globalization is key. Therefore, assessing and developing global leadership competencies is an important topic in human resource development (HRD). Global leadership competencies encompass personality traits, knowledge, and skills, as well as behaviors. While there has been a plethora of scholar-practitioner literature identifying global leadership competencies, there has been far less focus on assessing global leadership competencies and how these competencies are developed. The Solution We attempt to address this gap by examining the state-of-the-art literature on global leadership assessment and development from several disciplines, including HRD, management, and leadership. With regard to global leadership competency assessment, our goal is to synthesize the literature and provide HRD professionals with a systematic method for identifying instruments that measure core global competencies. With regard to global leadership development, our aim is to provide a framework for understanding how global leadership competencies can be developed. The Stakeholders The identification and categorization of various instruments that measure global competencies, as well as a framework that outlines methods to develop these competencies, will benefit human resource (HR) professionals and HRD practitioners.
Exploring the use of technology pathways to access health information by Australian university students: a multi-dimensional approach
Authors: Usher Wayne , Gudes Ori , Parekh Sanjoti 
Published: May 2016

Objective: Mobile wireless communication technologies (MWCT) and social media (SM) networks create pathways for accessing widely available information that are favoured particularly by younger generations. The purpose of this study was to explore the way university students use these communication technologies to access health information. Method: Participants ( n = 696), who were recruited via an email invitation, completed an online self-reported survey that collected multi-dimensional data consisting of quantitative, qualitative and spatial statistics. Results: The results indicate that technology was used extensively to search for health information and resulted in positive changes in participants’ behaviours; however they perceived lack of reliability of the information as a pressing issue. Conclusion: The results suggest that appealing, persuasive and reliable MWCT and SM can be used extensively to promote health amongst Australian youth.
Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo
Authors: Kovtonyuk Larisa V. , Manz Markus G. , Takizawa Hitoshi 
Published: May 2016

Key Points
Mpl agonist, but not granulocyte colony-stimulating factor, induces self-renewing HSC divisions and expansions.
Cervical Abnormalities in South African Women Living With HIV With High Screening and Referral Rates
Authors: Katz Ingrid T. , Butler Lisa M. , Crankshaw Tamaryn L. , Wright Alexi A. , Bramhill Karen , Leone Dominick A. , Giddy Janet , Mould Sean 
Published: May 2016

Purpose To determine the prevalence of screening, cervical dysplasia, and malignancy on the basis of histologic diagnoses from colposcopy and large loop excision of the transformation zone among women living with HIV (WLWH) who attended an urban antiretroviral treatment (ART) clinic in KwaZulu-Natal, South Africa. Materials and Methods We performed a retrospective cohort study to examine a random sample of 462 WLWH during a 5-year period from 2004 to 2009. Women on ART for < 3 months were excluded. Data were abstracted from electronic records and paper charts to assess rates of cervical abnormalities detected on Pap smears as well as time to colposcopy. Results During the study period, 432 women (93.5%) had at least one evaluable Papanicolau test. At baseline, 237 women (54.9%) had an abnormal Papanicolau test, and of these patients, 181 (76.3%) had a Papanicolau test that qualified for further colposcopic evaluation. In addition, 115 women (63.5%) received colposcopy within a median of 39 days from referral. This yielded 74 evaluable histologic samples (64.3%), of which 21.6%, 27.0%, 27.0%, and 1.4% had cervical intraepithelial neoplasia (CIN) 1, CIN2, CIN3, and invasive cervical cancer, respectively. Conclusion In a large sample of WLWH who received ART in KwaZulu-Natal, South Africa, where Papanicolau test coverage and rates of referral for colposcopy and large loop excision of the transformation zone were high, > 75% of women with evaluable histologic samples had evidence of cervical dysplasia or malignancy. These findings underscore the importance of routine cervical screening upon entry into HIV care to optimize survival.
(How) do animals know how much they weigh?
Authors: Schilder Rudolf J. 
Published: May 2016

ABSTRACTAnimal species varying in size and musculoskeletal design all support and move their body weight. This implies the existence of evolutionarily conserved feedback between sensors that produce quantitative signals encoding body weight and proximate determinants of musculoskeletal designs. Although studies at the level of whole organisms and tissue morphology and function clearly indicate that musculoskeletal designs are constrained by body weight variation, the corollary to this – i.e. that the molecular-level composition of musculoskeletal designs is sensitive to body weight variation – has been the subject of only minimal investigation. The main objective of this Commentary is to briefly summarize the former area of study but, in particular, to highlight the latter hypothesis and the relevance of understanding the mechanisms that control musculoskeletal function at the molecular level. Thus, I present a non-exhaustive overview of the evidence – drawn from different fields of study and different levels of biological organization – for the existence of body weight sensing mechanism(s).
Ontogenetic changes in larval swimming and orientation of pre-competent sea urchin Arbacia punctulata in turbulence
Authors: Wheeler Jeanette D. , Chan Kit Yu Karen , Anderson Erik J. , Mullineaux Lauren S. 
Published: May 2016

ABSTRACT
Many marine organisms have complex life histories, having sessile adults and relying on the planktonic larvae for dispersal. Larvae swim and disperse in a complex fluid environment and the effect of ambient flow on larval behavior could in turn impact their survival and transport. However, to date, most studies on larvae–flow interactions have focused on competent larvae near settlement. We examined the importance of flow on early larval stages by studying how local flow and ontogeny influence swimming behavior in pre-competent larval sea urchins, Arbacia punctulata. We exposed larval urchins to grid-stirred turbulence and recorded their behavior at two stages (4- and 6-armed plutei) in three turbulence regimes. Using particle image velocimetry to quantify and subtract local flow, we tested the hypothesis that larvae respond to turbulence by increasing swimming speed, and that the increase varies with ontogeny. Swimming speed increased with turbulence for both 4- and 6-armed larvae, but their responses differed in terms of vertical swimming velocity. 4-Armed larvae swam most strongly upward in the unforced flow regime, while 6-armed larvae swam most strongly upward in weakly forced flow. Increased turbulence intensity also decreased the relative time that larvae spent in their typical upright orientation. 6-Armed larvae were tilted more frequently in turbulence compared with 4-armed larvae. This observation suggests that as larvae increase in size and add pairs of arms, they are more likely to be passively re-oriented by moving water, rather than being stabilized (by mechanisms associated with increased mass), potentially leading to differential transport. The positive relationship between swimming speed and larval orientation angle suggests that there was also an active response to tilting in turbulence. Our results highlight the importance of turbulence to planktonic larvae, not just during settlement but also in earlier stages through morphology–flow interactions.