bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical model predictions of autogenic fluvial terraces and comparison to climate change expectations
Authors: Limaye Ajay B. S. , Lamb Michael P. 
Published: February 2016

AbstractTerraces eroded into sediment (alluvial) and bedrock (strath) preserve an important history of river activity. River terraces are thought to form when a river switches from a period of slow vertical incision and valley widening to fast vertical incision and terrace abandonment. Consequently, terraces are often interpreted to reflect changing external drivers including tectonics, sea level, and climate. In contrast, the intrinsic unsteadiness of lateral migration in rivers may generate terraces even under constant rates of vertical incision without external forcing. To explore this mechanism, we simulate landscape evolution by a vertically incising, meandering river and isolate the age and geometry of autogenic river terraces. Modeled autogenic terraces form for a wide range of lateral and vertical incision rates and are often paired and longitudinally extensive for intermediate ratios of vertical‐to‐lateral erosion rate. Autogenic terraces have a characteristic reoccurrence time that scales with the time for relief generation. There is a preservation bias against older terraces due to reworking of previously visited parts of the valley. Evolving, spatial differences in bank strength between bedrock and sediment reduce terrace formation frequency and length, favor pairing, and can explain sublinear terrace margins at valley boundaries. Age differences and geometries for modeled autogenic terraces are consistent, in cases, with natural terraces and overlap with metrics commonly attributed to terrace formation due to climate change. We suggest a new phase space of terrace properties that may allow differentiation of autogenic terraces from terraces formed by external drivers.
Bias reduction in decadal predictions of West African monsoon rainfall using regional climate models
Authors: Paxian A. , Sein D. , Panitz H.‐J. , Warscher M. , Breil M. , Engel T. , Tödter J. , Krause A. , Cabos Narvaez W. D. , Fink A. H. , Ahrens B. , Kunstmann H. , Jacob D. , Paeth H. 
Published: February 2016

AbstractThe West African monsoon rainfall is essential for regional food production, and decadal predictions are necessary for policy makers and farmers. However, predictions with global climate models reveal precipitation biases. This study addresses the hypotheses that global prediction biases can be reduced by dynamical downscaling with a multimodel ensemble of three regional climate models (RCMs), a RCM coupled to a global ocean model and a RCM applying more realistic soil initialization and boundary conditions, i.e., aerosols, sea surface temperatures (SSTs), vegetation, and land cover. Numerous RCM predictions have been performed with REMO, COSMO‐CLM (CCLM), and Weather Research and Forecasting (WRF) in various versions and for different decades. Global predictions reveal typical positive and negative biases over the Guinea Coast and the Sahel, respectively, related to a southward shifted Intertropical Convergence Zone (ITCZ) and a positive tropical Atlantic SST bias. These rainfall biases are reduced by some regional predictions in the Sahel but aggravated by all RCMs over the Guinea Coast, resulting from the inherited SST bias, increased westerlies and evaporation over the tropical Atlantic and shifted African easterly waves. The coupled regional predictions simulate high‐resolution atmosphere‐ocean interactions strongly improving the SST bias, the ITCZ shift and the Guinea Coast and Central Sahel precipitation biases. Some added values in rainfall bias are found for more realistic SST and land cover boundary conditions over the Guinea Coast and improved vegetation in the Central Sahel. Thus, the ability of RCMs and improved boundary conditions to reduce rainfall biases for climate impact research depends on the considered West African region.
Partitioning evapotranspiration based on the concept of underlying water use efficiency
Authors: Zhou Sha , Yu Bofu , Zhang Yao , Huang Yuefei , Wang Guangqian 
Published: February 2016

AbstractEvapotranspiration (ET) is dominated by transpiration (T) in the terrestrial water cycle. However, continuous measurement of transpiration is still difficult, and the effect of vegetation on ET partitioning is unclear. The concept of underlying water use efficiency (uWUE) was used to develop a new method for ET partitioning by assuming that the maximum, or the potential uWUE is related to T while the averaged or apparent uWUE is related to ET. T/ET was thus estimated as the ratio of the apparent over the potential uWUE using half‐hourly flux data from 17 AmeriFlux sites. The estimated potential uWUE was shown to be essentially constant for 14 of the 17 sites, and was broadly consistent with the uWUE evaluated at the leaf scale. The annual T/ET was the highest for croplands, i.e., 0.69 for corn and 0.62 for soybean, followed by grasslands (0.60) and evergreen needle leaf forests (0.56), and was the lowest for deciduous broadleaf forests (0.52). The enhanced vegetation index (EVI) was shown to be significantly correlated with T/ET and could explain about 75% of the variation in T/ET among the 71 site‐years. The coefficients of determination between EVI and T/ET were 0.84 and 0.82 for corn and soybean, respectively, and 0.77 for deciduous broadleaf forests and grasslands, but only 0.37 for evergreen needle leaf forests. This ET partitioning method is sound in principle and simple to apply in practice, and would enhance the value and role of global FLUXNET in estimating T/ET variations and monitoring ecosystem dynamics.
Derivation of Human Skin Fibroblast Lines for Feeder Cells of Human Embryonic Stem Cells
Authors: Unger Christian , Felldin Ulrika , Rodin Sergey , Nordenskjöld Agneta , Dilber Sirac , Hovatta Outi 
Published: February 2016

AbstractAfter the first derivations of human embryonic stem cell (hESC) lines on fetal mouse feeder cell layers, the idea of using human cells instead of mouse cells as feeder cells soon arose. Mouse cells bear a risk of microbial contamination, and nonhuman immunogenic proteins are absorbed from the feeders to hESCs. Human skin fibroblasts can be effectively used as feeder cells for hESCs. The same primary cell line, which can be safely used for up to 15 passages after stock preparations, can be expanded and used for large numbers of hESC derivations and cultures. These cells are relatively easy to handle and maintain. No animal facilities or animal work is needed. Here, we describe the derivation, culture, and cryopreservation procedures for research‐grade human skin fibroblast lines. We also describe how to make feeder layers for hESCs using these fibroblasts. © 2016 by John Wiley & Sons, Inc.
HT‐SPOTi: A Rapid Drug Susceptibility Test (DST) to Evaluate Antibiotic Resistance Profiles and Novel Chemicals for Anti‐Infective Drug Discovery
Authors: Danquah Cynthia A. , Maitra Arundhati , Gibbons Simon , Faull Jane , Bhakta Sanjib 
Published: February 2016

AbstractAntibiotic resistance is one of the major threats to global health and well‐being. The past decade has seen an alarming rise in the evolution and spread of drug‐resistant strains of pathogenic microbes. The emergence of extensively drug resistant (XDR) strains of Mycobacterium tuberculosis and antimicrobial resistance among the ESKAPE (
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nterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and
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nterobacter species) as well as fungal pathogens (such as certain species of Candida, Aspergillus, Cryptococcus, and Trichophyton) poses a significant 21st century scientific challenge. With an extremely limited arsenal of efficacious antibiotics, techniques that can (a) identify novel antimicrobials and (b) detect antimicrobial resistance are becoming increasingly important. In this article, we illustrate the HT‐SPOTi, an assay that is principally based on the growth of an organism on agar medium containing a range of different concentrations of drugs or inhibitors. The simple methodology makes this assay ideal for evaluating novel antimicrobial compounds as well as profiling an organism's antibiotic resistance profile. © 2016 by John Wiley & Sons, Inc.
Output outlier robust state estimation
Authors: De Palma Daniela , Indiveri Giovanni 
Published: February 2016

SummaryThis work addresses state estimation in presence of outliers in observed data. Outlying data and measurements have a most relevant impact in many control and signal processing applications including marine systems related ones: underwater navigation systems exploiting acoustic data, for example, are frequently affected by outlying measurements. Other on‐board sensors and devices are likely to produce measurements contaminated by outlier because of the harsh operating conditions of marine systems. Given the general interest for dealing with measurement outliers in a number of applications, this paper describes a state estimation solution exhibiting robustness to output outliers. The system model is assumed to be linear (either time varying or time invariant) discrete time. The proposed observer is designed by extending an outlier robust static parameter identification algorithm to the case of a linear dynamic plant. The designed estimator has a predictor/corrector structure like the Kalman filter and the Luenberger observer. Simulation and experimental results are provided illustrating the robustness of the derived solution to measurement outliers as compared with the Kalman filter. The proposed solution is also compared with alternative outlier robust state estimation filters showing its effectiveness, in particular, in the presence of measurements outliers occurring in a consecutive sequence. Because of its deterministic execution time and limited numerical complexity, the proposed state estimator can be readily applied in real‐time applications. Copyright © 2016 John Wiley & Sons, Ltd.
Brook/Elimination/Aldol Reaction Sequence for the Direct One‐Pot Preparation of Difluorinated Aldols from (Trifluoromethyl)trimethylsilane and Acylsilanes
Authors: Decostanzi Mélanie , Godemert Jérémy , Oudeyer Sylvain , Levacher Vincent , Campagne Jean‐Marc , Leclerc Eric 
Published: February 2016

AbstractA methodology allowing the one‐pot preparation of difluorinated aldols directly from Ruppert–Prakash reagent, acyltrimethylsilanes and aldehydes is reported. The process, initiated by a catalytic amount of an ammonium salt, involves the addition of (trifluoromethyl)trimethylsilane to the acylsilane, followed by a Brook rearrangement and elimination of a fluoride anion that promotes the subsequent aldol reaction. An efficient racemic reaction catalyzed by tetrabutylammonium difluorotriphenylsilicate is described, as well as our first efforts towards an asymmetric version.magnified image
Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients
Authors: Schüle Rebecca , Wiethoff Sarah , Martus Peter , Karle Kathrin N. , Otto Susanne , Klebe Stephan , Klimpe Sven , Gallenmüller Constanze , Kurzwelly Delia , Henkel Dorothea , Rimmele Florian , Stolze Henning , Kohl Zacharias , Kassubek Jan , Klockgether Thomas , Vielhaber Stefan , Kamm Christoph , Klopstock Thomas , Bauer Peter , Züchner Stephan , Liepelt‐Scarfone Inga , Schöls Ludger 
Published: February 2016

ObjectiveHereditary spastic paraplegias (HSPs) are genetically driven disorders with the hallmark of progressive spastic gait disturbance. To investigate the phenotypic spectrum, prognostic factors, and genotype‐specific differences, we analyzed baseline data from a continuous, prospective cohort.MethodsWe recruited 608 HSP cases from 519 families of mostly German origin. Clinical severity was assessed by the Spastic Paraplegia Rating Scale. Complicating symptoms were recorded by a standardized inventory.ResultsFamily history indicated dominant (43%), recessive (10%), and simplex (47%) disease. We observed a significant male predominance, particularly in simplex cases without a genetic diagnosis. Disease severity increased with disease duration. Earlier disease onset was associated with less severe disease. Specific complicating features including cognitive impairment, extrapyramidal or peripheral motor involvement, and ataxia were associated with worse disease severity. Disease severity also depended on the genotype. HSP cases maintained the ability to walk independently for a median disease duration of 22 years. Early onset cases were able to maintain free walking significantly longer and were at less risk to become wheelchair dependent.InterpretationThis cross‐sectional cohort study provides the first large‐scale data on disease manifestation, progression, and modifying factors, with relevance for counseling of HSP families and planning of future cross‐sectional and natural history studies. Later age of onset, specific complicating features, and the SPG11 genotype are strongly associated with more severe disease. Future interventional studies will require stratification for modifiers of disease progression identified in this study. Prospective longitudinal studies will verify progression rates calculated in this baseline analysis. Ann Neurol 2016;79:646–658
Permeation of fertilizer nutrients through polymer membrane: part I. Effect of P, K, and micronutrient fertilizer on permeability of urea
Authors: Li Xing , Bei Lei , Sun Zhi , Liu Kun , Zhang Xu , Han Xiaozhao 
Published: February 2016

AbstractThe study aimed at investigating the addition effects of P, K, and micronutrient fertilizers on the permeability of N‐nutrient fertilizer urea through a representative polymer membrane, which is of great importance in polymer‐coated compound fertilizer. Specifically, the permeability of urea through polystyrene membrane was determined experimentally at the nominal temperature of 298 K using the Ussing chamber method for fertilizer solutions of urea–water, urea–NaH2PO4–water, urea–Ca(H2PO4)2–water, urea–KCl–water, and urea–NaCl–water. The experimental data showed that the addition effects of NaH2PO4, KCl, and NaCl on urea permeability were pronounced and could be promotion or suppression depending on the amounts added. The variation of urea permeability with additive concentration could be explained by the ‘solution–diffusion’ model, suggesting that the specific intermolecular and interionic interactions in the permeation solution were an important factor determining the permeability. Using the saturated urea–water solution as basis, the addition of saturated KCl increased the urea permeability by 2.5 times, while the addition of saturated Ca(H2PO4)2 and NaH2PO4 decreased the permeability by 41% and 76%, respectively. © 2016 Curtin University of Technology and John Wiley & Sons, Ltd.
Morphological, thermal, and mechanical properties of poly(ε‐caprolactone)/poly(ε‐caprolactone)‐grafted‐cellulose nanocrystals mats produced by electrospinning
Authors: Bellani Caroline F. , Pollet Eric , Hebraud Anne , Pereira Fabiano V. , Schlatter Guy , Avérous Luc , Bretas Rosario E. S. , Branciforti Marcia C. 
Published: February 2016

ABSTRACTElectrospun nanocomposites of poly(ε‐caprolactone) (PCL) incorporated with PCL‐grafted cellulose nanocrystals (PCL‐g‐CNC) were produced. PCL chains were grafted from cellulose nanocrystals (CNC) surface by ring‐opening polymerization. Grafting was confirmed by infrared spectroscopy (FTIR) and thermogravimetric analyses (TGA). The resulting PCL‐g‐CNC were then incorporated into a PCL matrix at various loadings. Homogeneous nanofibers with average diameter decreasing with the addition of PCL‐g‐CNC were observed by scanning electron microscopy (SEM). PCL‐g‐CNC domains incorporated into the PCL matrix were visualized by transmission electron microscopy (TEM). Thermal and mechanical properties of the mats were analyzed by differential scanning calorimetry (DSC), TGA and dynamic mechanical analysis (DMA). The addition of PCL‐g‐CNC into the PCL matrix caused changes in the thermal behavior and crystallinity of the electrospun fibers. Significant improvements in Young's modulus and in strain at break with increasing PCL‐g‐CNC loadings were found. These results highlighted the great potential of cellulose nanocrystals as a reinforcement phase in electrospun PCL mats, which can be used as biomedical materials. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43445.
Functionalized polymeric silver nanoparticle hybrid network as a dual antimicrobe:Synthesis, characterization, and antibacterial application
Authors: Anirudhan T. S. , Deepa Binusreejayan, J. R. 
Published: February 2016

ABSTRACTThe present work describes a novel method for the synthesis of silver polymer nanocomposite for the delivery of amoxicillin (AMO). Silver nanoparticles (AgNPs) were synthesized with chitosan and silver nitrate. The reaction parameters were optimized. Three‐dimensional polymeric networks were synthesized by simple free‐radical graft copolymerization. UV–visible spectroscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, SEM, atomic force microscopy, dynamic light scattering, and zeta potential analysis were used for the complete characterization of the samples. Swelling studies and swelling factors were evaluated.In vitrorelease of AMO and AgNPs at physiological pHs was analyzed using the Peppas kinetic model to explain the drug delivery mechanism. Cytotoxicity, free‐radical scavenging, and antibacterial activities were analyzed. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2016,133, 43479.
Influence of flow diversions on giant freshwater pearl mussel populations in the Ebro River, Spain
Authors: Araujo Rafael , Álvarez‐Cobelas Miguel 
Published: February 2016

Abstract

Freshwater mussels, historically a component of freshwater benthic invertebrate biomass, are one of the most imperilled animal groups on the planet. Margaritifera auricularia was once a common freshwater mussel inhabiting large rivers throughout Western Europe. It was believed to be extinct until 1996 when a few small populations were found in Spain and France.
Currently M. auricularia is one of the most endangered species in the world. The current status of this mollusc in the Ebro River was surveyed, finding a few adult specimens at only two localities, and many old, empty shells throughout the river.
Using a simple analysis of historical hydrological data, dramatic changes in water flow might have led to localized extirpation of this freshwater mussel.
Other factors contributing to the slow extirpation of this long‐lived invertebrate from other areas of the Ebro Basin include the continuous reduction of water levels during the reproductive season, overharvesting for nacre, construction of impoundments, extinction of fish hosts, and impaired water quality.
Copyright © 2016 John Wiley & Sons, Ltd.
Plasma metabonomics study on toxicity biomarker in rats treated with Euphorbia fischeriana based on LC–MS
Authors: Wang Yingfeng , Man Hongxue , Gao Jian , Liu Xinfeng , Ren Xiaolei , Chen Jianxin , Zhang Jiayu , Gao Kuo , Li Zhongfeng , Zhao Baosheng 
Published: February 2016

AbstractLang‐du (LD) has been traditionally used to treat human diseases in China. Plasma metabolic profiling was applied in this study based on LC–MS to elucidate the toxicity in rats induced by injected ethanol extract of LD. LD injection was given by intraperitoneal injection at doses of 0.1, 0.05, 0.025 and 0 g kg−1 body weight per day to rats. The blood biochemical levels of alanine aminotransferase, direct bilirubin, creatinine, serum β2‐microglobulin and low‐density lipoprotein increased in LD‐injected rats, and the levels of total protein and albumin decreased in these groups. The metabolic profiles of the samples were analyzed by multivariate statistics analysis, including principal component analysis, partial least squares discriminant analysis and orthogonal projection to latent structures discriminate analysis (OPLS‐DA). The metabolic characters in rats injected with LD were perturbed in a dose‐dependent manner. By OPLS‐DA, 18 metabolites were served as the potential toxicity biomarkers. Moreover, LD treatment resulted in an increase in the p‐cresol, p‐cresol sulfate, lysophosphatidylethanolamine (LPE) (18:0), LPE (16:0), lysophosphatidylcholine (16:0) and 12‐HETE concentrations, and a decrease in hippuric acid, cholic acid and N‐acetyl‐l‐phenylalanine. These results suggested that chronic exposure to LD could cause a disturbance in lipids metabolism and amino acids metabolism, etc. Therefore, an analysis of the metabolic profiles can contribute to a better understanding of the adverse effects of LD. Copyright © 2016 John Wiley & Sons, Ltd.
An Afterword to Indexing It All: The Subject in the Age of Documentation, Information, and Data
Authors: Day Ronald E. 
Published: February 2016

EDITOR'S SUMMARYFor his book Indexing It All: The Subject in the Age of Documentation, Information, and Data, Ronald E. Day was honored with the 2015 ASIS&T Best Information Science Book award. In this afterword, Day explains that the book examines the concept of “aboutness” in the modern documentary tradition covering information science and data science. In writing the book, Day wanted to sort out the relationship between subject and object, between user and document, the core of information science and prelude to information retrieval. He considers the transition of a text serving a group audience to a document serving individual user needs, facilitated by an array of digital technologies. Referencing historical precursors Paul Otlet and Suzanne Briet, he considers documentation as evidence that, depending on the viewpoint chosen, may be a construction or a representation of a concept. Day considers his book a dystopian work, asserting that information technology has been charged with answering both information and cultural needs and has given rise to users’ addiction to technology. He anticipates data and documents to both influence and be influenced by evolving technologies, cultural forms and social norms with the document form persisting, though transformed.
Research Data Integration in the Purdue Libraries
Authors: Zilinski Lisa D. , Barton Amy , Zhang Tao , Pouchard Line , Pascuzzi Pete 
Published: February 2016

EDITOR'S SUMMARYAt the 2015 ASIS&T Research Data Access and Preservation (RDAP) Summit, panelists from Research Data @ Purdue University Libraries discussed the organizational structure intended to promote campus‐wide collaboration among diverse data specialists. Amy Barton explained her role as metadata specialist for research data and the importance of being engaged with evolving standards and best practices. As digital user experience specialist, Tao Zhang evaluated the Data Curation Profiles Toolkit, including an interview protocol librarians use to explore researchers’ data needs and a web application for researchers to create data management plans. Line Pouchard, an information specialist focusing on big data, explored the data curation lifecycle model in general and its unique aspects in the context of big data. Information specialist for molecular biosciences, Pete Pascuzzi addressed the importance of bioinformatics for data reuse and having librarians work in an embedded position with researchers.