bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac headache in acute coronary syndrome
Authors: Tran Phillip , Ziffra Robert , Nguyen Hoai V. , Losee Selena M. 
Published: June 2017

Acute coronary syndrome may present in a wide distribution of symptoms. The classic presentation includes substernal chest pain, neck pain, dyspnea or syncope. In patients with coronary risk factors who present with headaches, acute coronary syndrome is rare, but has been previously reported. We describe a case of 63-year-old female who presented with a severe headache and developed a Non ST Elevation Myocardial Infarction.
Practical Applications of Immunohistochemistry in the Diagnosis of Genitourinary Tumors
Authors: Xiao Xiuli , Hu Rong , Deng Fang-Ming , Shen Steven S. , Yang Ximing J. , Wu Chin-Lee 
Published: June 2017

Context.—Pathologic diagnosis of tumors in the genitourinary system can be challenging based on morphology alone, particularly when diagnostic material is limited, such as in core biopsies. Immunohistochemical stain can be a useful tool to aid in the diagnosis.Objective.—To provide an update on practical applications and interpretation of immunohistochemical stains in the diagnosis of tumors in prostate, kidney, bladder, and testis. We particularly focus on difficult differential diagnoses, providing our insights in frequently encountered challenging situations. Commonly used immunohistochemical panels are discussed.Data Sources.—Review of literature and our own experience.Conclusion.—Immunohistochemical stain is a valuable tool in the diagnosis of genitourinary tumors when appropriately used.
Use of predeposited autologous blood plus intraoperative autotransfusion compared with use of predeposited autologous blood alone in radical retropubic prostatectomy
Authors: Ginsberg, Phillip C. , Chiusano Michael A. , Finkelstein, Leonard H. , Mene Matthew 
Published: June 2017

Abstract
The efficacy of combining preoperative autologous blood donation with the intraoperative use of an autotransfuser during radical retropubic prostatectomy was examined by retrospective analysis of the charts of 27 patients who underwent this procedure between February 1989 and August 1992. An intraoperative autotransfuser was combined with 2 units of pre donated autologous blood in 14 patients (group 1), with 4 (29%) of the 14 requiring homologous blood. In group 2, 5 (62%) of 8 patients required homologous blood. For the remaining 5 patients (group 3), no autologous blood was available, so all received homologous blood transfusion. Preliminary data suggest that ideally, patients scheduled for radical prostatectomy should attempt to store at least 2 units of autologous blood and have an autotransfuser available during surgery.
Carpal tunnel syndrome and motor vehicle accidents
Authors: Ames Elliot L. 
Published: June 2017

Abstract
Carpal tunnel syndrome can result from acute injury, as indicated by a retrospective study. Symptoms of carpal tunnel syndrome developed in 96 patients within 2 months after an automobile accident. Forty-four (46%) of these 96 patients underwent carpal tunnel release. It is postulated that the mechanism of injury is blunt trauma from the steering wheel or dashboard.
Current trends in the pharmacologic and surgical treatment of Parkinson's disease
Authors: Galler Robert Michael , Hallas Brian H. , Fazzini, Enrico 
Published: June 2017

Abstract
Recently, there has been a surge in the research regarding the pharmacologic and surgical treatment of Parkinson's disease. This article reviews the latest modes of medical and surgical therapy for Parkinson's disease. The latest drug therapy has consisted of levodopa, a combination of levodopa and carbidopa (Sinemet/Sinemet CR), and monoamine oxidase type B (MAO-B) inhibitors (selegiline hydrochloride). The surgical treatment modalities have been stereotaxic implantations of dopamine-producing tissues (such as adrenal medulla and fetal mesencephalon) into the caudate nucleus and ventral pallidotomy of patients with Parkinson's disease. The most recent work has been in the field of gene therapy. The implantation of cells genetically modified to express trophic factors and tyrosine hydroxylase for the synthesis of L-dopa from tyrosine has been proposed as a possible route for the treatment of Parkinson's disease. Although the etiology of the disease is still unknown, two recent theories are discussed.
Ischemic cerebellar infarct in a 5-year-old boy: Sequela to minor back trauma
Authors: Byrd Lorraine Rose , Vogel H. Lauren 
Published: June 2017

Abstract
Minor trauma, a kick to the center of the back during roughhousing with an 8-year-old sibling, produced an ischemic cerebellar infarct in a 5-year-old boy. The boy was brought to medical attention because of vomiting and headache. He also had ataxia. Results of laboratory studies, structural examination, and cerebrospinal fluid analysis were noncontributory. An irregular, low-density region in the left cerebellar hemisphere of unknown cause was seen on computed tomography scans. Magnetic resonance imaging (MRI) revealed an area of signal alteration hyperintense on the T2-weighted image and mildly hyperintense on the proton-density image in the leftward cerebellar hemisphere. The distribution was most compatible with that of an acute superior cerebellar arterial infarction. No other abnormalities were detected. The patient was treated with oral prednisolone, recovered, and had no further episodes or sequelae. The authors recommend that posttraumatic stroke be considered early in the differential diagnosis of a child with the triad of symptoms seen in the patient described. They suggest that glucocorticoid therapy on a short-term basis may have a place in more rapid resolution of symptoms.
Hurthle cell carcinoma of the thyroid
Authors: Gray Michael W. , Caleel Richard T. 
Published: June 2017

Abstract
Hurthle cell tumors of the thyroid are uncommon neoplasms that generate considerable controversy regarding the correct clinicopathologic criteria for determining which lesions require aggressive surgical management and which lesions require conservative therapy. The neoplasms range from benign tumors that disappear spontaneously to tumors with widespread metastasis. The origin of these tumors is unclear, their clinical course is variable and largely unpredictable, and diagnosis is difficult. Neither atypical architecture nor cytologic features are reliable indicators of malignancy. Surgery is the only effective treatment modality. The authors present two case studies of patients with Hurthle cell carcinoma. They also discuss the natural history and management of this disease.
Integrated geophysical characteristics of the 2015 Illapel, Chile, earthquake
Authors: Herman Matthew W. , Nealy Jennifer L. , Yeck William L. , Barnhart William D. , Hayes Gavin P. , Furlong Kevin P. , Benz Harley M. 
Published: June 2017

AbstractOn 16 September 2015, aMw8.3 earthquake ruptured the subduction zone offshore of Illapel, Chile, generating an aftershock sequence with 14Mw6.0–7.0 events. A double sourceWphase moment tensor inversion consists of aMw7.2 subevent and the mainMw8.2 phase. We determine two slip models for the mainshock, one using teleseismic broadband waveforms and the other using static GPS and InSAR surface displacements, which indicate high slip north of the epicenter and west‐northwest of the epicenter near the oceanic trench. These models and slip distributions published in other studies suggest spatial slip uncertainties of ~25 km and have peak slip values that vary by a factor of 2. We relocate aftershock hypocenters using a Bayesian multiple‐event relocation algorithm, revealing a cluster of aftershocks under the Chilean coast associated with deep (20–45 km depth) mainshock slip. Less vigorous aftershock activity also occurred near the trench and along strike of the main aftershock region. Most aftershocks are thrust‐faulting events, except for normal‐faulting events near the trench. Coulomb failure stress change amplitudes and signs are uncertain for aftershocks collocated with deeper mainshock slip; other aftershocks are more clearly associated with loading from the mainshock. These observations reveal a frictionally heterogeneous interface that ruptured in patches at seismogenic depths (associated with many aftershocks) and with homogeneous slip (and few aftershocks) up to the trench. This event likely triggered seismicity separate from the main slip region, including along‐strike events on the megathrust and intraplate extensional events.
Kinematic evidence for the effect of changing plate boundary conditions on the tectonics of the northern U.S. Rockies
Authors: Schmeelk Dylan , Bendick Rebecca , Stickney Michael , Bomberger Cody 
Published: June 2017

AbstractWe derive surface velocities from GPS sites in the interior Northwest U.S. relative to a fixed North American reference frame to investigate surface tectonic kinematics from the Snake River Plain (SRP) to the Canadian border. The Centennial Tectonic Belt (CTB) on the northern margin of the SRP exhibits west directed extensional velocity gradients and strain distributions similar to the main Basin and Range Province (BRP) suggesting that the CTB is part of the BRP. North of the CTB, however, the vergence of velocities relative to North America switches from westward to eastward along with a concomitant rotation of the principal stress axes based on available seismic focal mechanisms, revealing paired extension in the northern Rockies and shortening across the Rocky Mountain Front. This change in orientation of surface velocities suggests that the change in the boundary conditions on the western margin of North America influences the direction of gravitational collapse of Laramide thickened crust. Throughout the study region, fault slip rate estimates calculated from the new geodetic velocity field are consistently larger than previously reported fault slip rates determined from limited geomorphic and paleoseismic studies.
Carbon dating reveals a seasonal progression in the source of particulate organic carbon exported from the Greenland Ice Sheet
Authors: Kohler T. J. , Žárský J. D. , Yde J. C. , Lamarche‐Gagnon G. , Hawkings J. R. , Tedstone A. J. , Wadham J. L. , Box J. E. , Beaton A. D. , Stibal M. 
Published: June 2017

AbstractSurface melt from the Greenland Ice Sheet (GrIS) collects particulate organic carbon (POC) as it drains into subglacial environments and transports it downstream where it serves as a microbial substrate. We hypothesized that older POC is entrained by meltwaters as the subglacial drainage network expands upglacier over the summer. To test this, POC samples were collected from a meltwater river exiting the GrIS over an ablation season and 14C dated. Resulting values were compared with meltwater hydrochemistry and satellite observations of the catchment area. We found that POC ages increased from ~5000 to ~9000 years B.P. until peak discharge and catchment size. Afterward, significant fluctuations in POC age were observed, interpreted to result from periods of high and low subglacial hydrological pressure and sediment supply and subsequent exhaustion. These observations suggest a seasonal progression in the source of POC exported from the GrIS and provide evidence for a seasonally evolving subglacial drainage system.
Variation of atmospheric electric field measured at Vostok, Antarctica, during St. Patrick's Day storms on 24th solar cycle
Authors: Jeni Victor N. , Frank‐Kamenetsky A. V. , Manu S. , Panneerselvam C. 
Published: June 2017

AbstractThe influence of solar wind‐magnetosphere interaction on the atmospheric electric field is investigated in connection with the two severe geomagnetic storms during 24th solar cycle. The observation was carried out at Vostok (78°27′S, 106°52′E), Antarctica, during 17–18 March 2013 and 17–18 March 2015. Two consecutive substorms were observed at Vostok during the main phase of geomagnetic storms, where the disturbed ionospheric current is antisunward in the morning sector (~04:00–10:00 UT) and sunward in the noon‐afternoon sector (~11:00–16:00 UT). Interplanetary magnetic field (IMF) and solar wind interaction enhance the ionospheric potential, which in turn couple with Potential Gradient (PG) measured at ground level. Eventually, for the first time, the slope of ~1.0 Vm−1 per kV has been demonstrated between Vostok PG and overhead ionospheric potential (Weimer_05) during intense (Kp = 8) geomagnetic perturbation. The linear relation between PG and overhead potential is highly significant on positive coupling, i.e., positive ΔPG changes, whereas the offset of ~25 V/m has been estimated with negative coupling. Ionospheric convection map from Super Dual Auroral Radar Network is more compatible with PG on positive coupling, and for negative changes of PG, radar observation is more consistent than the Weimer_05 model. Ionospheric electric potential from radar observation and empirical model is highly compromised when a polar cap is dominated by a single negative potential region associated with IMF By ≪ 0. It is inferred that superposed overhead ionospheric potential on Vostok PG is highly effective when IMF maintained a steady flow, whereas it is less significance for rapid changes of solar wind‐IMF parameters.
Unique concurrent observations of whistler mode hiss, chorus, and triggered emissions
Authors: Hosseini Poorya , Gołkowski Mark , Turner Drew L. 
Published: June 2017

AbstractWe present a unique 2 h ground‐based observation of concurrent magnetospheric hiss, chorus, VLF triggered emissions as well as ELF/VLF signals generated locally by the High Frequency Active Auroral Research Program (HAARP) facility. Eccentricity of observed wave polarization is used as a criteria to identify magnetospheric emissions and estimate their ionospheric exit points. The observations of hiss and chorus in the unique background of coherent HAARP ELF/VLF waves and triggered emissions allow for more accurate characterization of hiss and chorus properties than in typical ground‐based observations. Eccentricity and azimuth results suggest a moving ionospheric exit point associated with a single ducted path at L ~ 5. The emissions exhibit dynamics in time suggesting an evolution of a magnetospheric source from hiss generation to chorus generation or a moving plasmapause location. We introduce a frequency band‐limited autocorrelation method to quantify the relative coherency of the emissions. A range of coherency was observed from high order of coherency in local HAARP transmissions and their echoes to lower coherency in natural chorus and hiss emissions.
Lewis Base Catalytic Properties of [Nb10O28]6− for CO2 Fixation to Epoxide: Kinetic and Theoretical Studies
Authors: Hayashi Shun , Yamazoe Seiji , Koyasu Kiichirou , Tsukuda Tatsuya 
Published: June 2017

AbstractThe decaniobate cluster (TBA)6[Nb10O28] (TBA+=tetrabutylammonium cation) was found to act as a Lewis base catalyst for fixation of carbon dioxide (CO2) to styrene oxide (SO). A kinetic study showed that the cycloaddition of CO2 adsorbed on [Nb10O28]6− with SO corresponds to the rate‐determining step in the Eley–Rideal mechanism. Density functional theory calculation predicted that CO2 on the corner and edge O atoms of [Nb10O28]6− is negatively charged and thus activated for nucleophilic attack on SO.
Co‐utilization of hexoses by a microconsortium of sugar‐specific E. coli strains
Authors: Chappell Todd C. , Nair Nikhil U. 
Published: June 2017

ABSTRACTEscherichia coli is an important commercial species used for production of biofuels, biopolymers, organic acids, sugar alcohols, and natural compounds. Processed biomass and agroindustrial byproducts serve as low‐cost nutrient sources and contain a variety of hexoses available for bioconversion. However, metabolism of hexose mixtures by E. coli is inefficient due to carbon catabolite repression (CCR), where the transport and catabolic activity of one or more carbon sources is repressed and/or inhibited by the transport and catabolism of another carbon source. In this work, we developed a microconsortium of different E. coli strains, each engineered to preferentially catabolize a different hexose—glucose, galactose, or mannose. We modified the specificity and preference of carbon source using a combination of rational strain design and adaptive evolution. The modifications ultimately resulted in strains that preferentially catabolized their specified sugar. Finally, comparative analysis in galactose‐ and mannose‐rich sugar mixtures revealed that the consortium grew faster and to higher cell densities compared to the wild‐type strain. Biotechnol. Bioeng. 2017;114: 2309–2318. © 2017 Wiley Periodicals, Inc.
Investigation of acid phosphatase variants for the synthesis of phosphate monoesters
Authors: Tasnádi Gábor , Zechner Michaela , Hall Mélanie , Baldenius Kai , Ditrich Klaus , Faber Kurt 
Published: June 2017

ABSTRACTThe major drawback of using phosphatases for transphosphorylation reactions lies in product depletion caused by the natural hydrolytic activity of the enzymes. Variants of PhoC‐Mm from Morganella morganii and NSAP‐Eb from Escherichia blattae were studied for their ability to maintain a high product level in the transphosphorylation of various primary alcohols. A single amino acid exchange delivered phosphatase variant PhoC‐Mm G92D, which was able to catalyze the phosphorylation of primary alcohols without any major hydrolysis of the formed phosphate esters. The mutation mostly improved the affinity of the enzyme for alcohols, while rate constants of transphosphorylation and hydrolysis were decreased, overall resulting in a superior catalytic efficiency in transphosphorylation compared to hydrolysis. The presence of residual substrate alcohol at a given concentration was crucial to suppress phosphate ester hydrolysis. The present work extends the synthetic applicability of phosphatase variants beyond the previously reported nucleosides and allows preparative‐scale production of various primary phosphate esters (yields up to 42%) with high enzyme productivity (TONs up to ∼66,000). Biotechnol. Bioeng. 2017;114: 2187–2195. © 2017 Wiley Periodicals, Inc.
Utilization of UPLC/Q‐TOF‐MS‐Based Metabolomics and AFLP‐Based Marker‐Assisted Selection to Facilitate/Assist Conventional Breeding of Polygala tenuifolia
Authors: Li Juan , Wang Dan‐Dan , Xu Xiao‐Shuang , Bai Lu , Peng Bing , Pu Ya‐Jie , Tian Hong‐Ling , Qin Xue‐Mei , Zhang Fu‐Sheng , Ma Cun‐Gen 
Published: June 2017

As one of the most important traditional Chinese medicine, the quality of Polygala tenuifolia is difficult to control and a new method must be established to facilitate/assist the breeding of P. tenuifolia. In this study, UPLC/Q‐TOF‐MS‐based metabolomics analysis was performed to determine the chemical composition and screen metabolite biomarkers according to agronomic traits. A total of 29 compounds and 18 metabolite biomarkers were found. AFLP‐based marker‐assisted selection (MAS) was used to identify molecular marker bands and screen characteristic bands associated with specific agronomic traits. 184 bands and 76 characteristic AFLP bands were found. The correlation network between compounds and characteristic AFLP bands was built, so we may directly breed certain P. tenuifolia herbs with special agronomic traits (or characteristic AFLP bands), which exhibit specific pharmacological functions depending on the content of the active compounds. The proposed method of metabolomics coupled with MAS could facilitate/assist the breeding of P. tenuifolia.
MONITORING CRUSTAL DEFORMATION AND GRAVITY CHANGE CAUSED BY THE TERRESTRIAL WATER LOAD IN THE THREE GORGES AREA BASE ON CORS NETWORK
Authors: Wei WANG , Ya‐Min DANG , Chuan‐Yin ZHANG , Li‐Feng BAO , Shi‐Ming LIANG , Zhi‐Tang HE , Zheng‐Bo ZOU 
Published: June 2017

AbstractThe Three Gorges region is rich in water resources. With the added impact of impoundment and discharge of the Three Gorges Reservoir, the regional hydrodynamic environment is complex, and research on the impacts of this terrestrial water is still relatively scarce. Using the CORS network supplemented by a small amount of gravity station data, and using the load deformation and gravitational field spherical harmonic analysis method, the crustal deformation and gravity changes caused by the terrestrial water in the Three Gorges area are studied. We find that it is possible to use the CORS network to monitor the crustal deformation and ground‐level gravity changes that are caused by the terrestrial water load. The impact of the terrestrial water load is up to the centimeter‐level on the vertical deformation, less on the horizontal deformation, and up to hundreds of microgals in the ground level gravity variations. From January 2011 to June 2015, the vertical deformation caused by the terrestrial water load change tends to be balanced, and the influences of gravity changes are mainly concentrated in the Three Gorges Reservoir and the Jianghan Plain. Except for some areas, the crustal vertical deformations caused by the terrestrial water measured by CORS and GRACE are highly consistent in their distribution patterns and trends. In this paper, the research results can be used for monitoring the hydrodynamic environment and for the protection and utilization of water resources, which can also be used to dynamically maintain the elevation and gravity benchmarks.
Estimating the accuracy of a reduced‐order model for the calculation of fractional flow reserve (FFR)
Authors: Boileau Etienne , Pant Sanjay , Roobottom Carl , Sazonov Igor , Deng Jingjing , Xie Xianghua , Nithiarasu Perumal 
Published: June 2017

AbstractImage‐based noninvasive fractional flow reserve (FFR) is an emergent approach to determine the functional relevance of coronary stenoses. The present work aimed to determine the feasibility of using a method based on coronary computed tomography angiography (CCTA) and reduced‐order models (0D‐1D) for the evaluation of coronary stenoses. The reduced‐order methodology (cFFRRO) was kept as simple as possible and did not include pressure drop or stenosis models. The geometry definition was incorporated into the physical model used to solve coronary flow and pressure. cFFRRO was assessed on a virtual cohort of 30 coronary artery stenoses in 25 vessels and compared with a standard approach based on 3D computational fluid dynamics (cFFR3D). In this proof‐of‐concept study, we sought to investigate the influence of geometry and boundary conditions on the agreement between both methods. Performance on a per‐vessel level showed a good correlation between both methods (Pearson's product‐moment R=0.885, P<0.01), when using cFFR3D as the reference standard. The 95% limits of agreement were −0.116 and 0.08, and the mean bias was −0.018 (SD =0.05). Our results suggest no appreciable difference between cFFRRO and cFFR3D with respect to lesion length and/or aspect ratio. At a fixed aspect ratio, however, stenosis severity and shape appeared to be the most critical factors accounting for differences in both methods. Despite the assumptions inherent to the 1D formulation, asymmetry did not seem to affect the agreement. The choice of boundary conditions is critical in obtaining a functionally significant drop in pressure. Our initial data suggest that this approach may be part of a broader risk assessment strategy aimed at increasing the diagnostic yield of cardiac catheterisation for in‐hospital evaluation of haemodynamically significant stenoses.