bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of oxidative phosphorylation signaling pathway on silkworm midgut following exposure to phoxim
Authors: Li Fanchi , Xu Kaizun , Ni Min , Wang Binbin , Gu Zhiya , Shen Weide , Li Bing 
Published: November 2015

ABSTRACTOrganophosphate pesticides are applied widely in the world for agricultural purposes, and their exposures often resulted in non‐cocooning of Bombyx mori in China. Silkworm midgut is the major organ for digestion and nutrient absorption, importantly it is also a barrier against foreign substances and chemical pesticides. The purpose of this study was to determine the mechanism of oxidative injury in silkworm midgut with phoxim induction. The results showed that the transcription level of oxidative phosphorylation signaling pathway genes of midgut under phoxim stress. Digital gene expression (DGE) analysis revealed that 24 electron transport chain (ETC)‐related genes were upregulated. Quantitative real time polymerase chain reaction results indicated that the ETC the genes encoding NADH‐CoQ1, Succinic‐Q, cyt c reductase‐S, cyt c oxidase‐S, cytochrome c oxidase polypeptide IV, ATP synthase, and vacuolar H+ ATP synthase were all significantly up‐regulated by 1.50‐, 1.31‐, 1.42‐, 1.44‐, 1.70‐, 2.03‐ and 1.43‐fold, respectively. Phoxim induction enhanced the activity of ETC complex in mitochondria, and induced the accumulation of ROS in midgut. These results indicated that trace phoxim enhanced respiration in midgut, and the imbalance between the activity changes of ETC may led to reactive oxygen species accumulation. The ETC of mitochondria may be potential biomarkers of midgut toxicity in B. mori caused by phoxim exposure. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 167–175, 2017.
QoE‐ and energy‐efficient resource optimization in OFDMA networks with bidirectional relaying
Authors: Ma Xiaolin , Li Fangmin , Ilow Jacek , Chen Zhizhang 
Published: November 2015

AbstractBecause of the surging demands of multimedia services, quality‐of‐experience (QoE) is becoming an important metric to evaluate network quality from users' perspective. In this paper, resource optimisation to achieve optimal tradeoff between QoE and energy consumption in bidirectional orthogonal frequency‐division multiple‐access relaying networks is addressed so as to provide satisfactory multimedia delivery quality and support green communications. We first formulate a QoE‐energy efficiency tradeoff optimisation where QoE requirements and relaying traffic balance are considered and prove that QoE‐energy efficiency is quasiconcave on QoE, which suggests the existence of a unique global optimal tradeoff point. We then propose an optimisation framework to achieve the optimal tradeoff efficiently. With the framework, we develop resource allocation approaches for two specific relaying strategies, that is, two‐phase decode‐and‐forward relaying with dynamic XOR network coding and compute‐and‐forward relaying with physical network coding via structured codes. Numerical results validate theoretical findings and demonstrate the effectiveness of the proposed optimisation solution for achieving the tradeoff between QoE and energy consumption. Copyright © 2015 John Wiley & Sons, Ltd.
Heterodinuclear Ruthenium(II) Complexes of the Bridging Ligand 1,6,7,12‐Tetraazaperylene with Iron(II), Cobalt(II), Nickel(II), as well as Palladium(II) and Platinum(II)
Authors: Brietzke Thomas , Kelling Alexandra , Schilde Uwe , Mickler Wulfhard , Holdt Hans‐Jürgen 
Published: November 2015

AbstractThe first heterodinuclear ruthenium(II) complexes of the 1,6,7,12‐tetraazaperylene (tape) bridging ligand with iron(II), cobalt(II), and nickel(II) were synthesized and characterized. The metal coordination sphere in this complexes is filled by the tetradentate N,N′‐dimethyl‐2,11‐diaza[3.3](2,6)‐pyridinophane (L‐N4Me2) ligand, yielding complexes of the general formula [(L‐N4Me2)Ru(µ‐tape)M(L‐N4Me2)](ClO4)2(PF6)2 with M = Fe {[2](ClO4)2(PF6)2}, Co {[3](ClO4)2(PF6)2}, and Ni {[4](ClO4)2(PF6)2}. Furthermore, the heterodinuclear tape ruthenium(II) complexes with palladium(II)‐ and platinum(II)‐dichloride [(bpy)2Ru(μ‐tape)PdCl2](PF6)2 {[5](PF6)2} and [(dmbpy)2Ru(μ‐tape)PtCl2](PF6)2 {[6](PF6)2}, respectively were also prepared. The molecular structures of the complex cations [2]4+ and [4]4+ were discussed on the basis of the X‐ray structures of [2](ClO4)4·MeCN and [4](ClO4)4·MeCN. The electrochemical behavior and the UV/Vis absorption spectra of the heterodinuclear tape ruthenium(II) complexes were explored and compared with the data of the analogous mono‐ and homodinuclear ruthenium(II) complexes of the tape bridging ligand.
Functionalized Paddle Wheel Complexes from BODIPY Carboxylic Acids
Authors: Höfler Sebastian , Scheja Anne , Wolfram Benedikt , Bröring Martin 
Published: November 2015

AbstractA series of BODIPY carboxylic acids carrying aromatic linking units between the luminophor and the carboxylate functional group was prepared using Sonogashira and Stille type coupling protocols. Ferrocene and hydroquinone units could be introduced by either of these methods. Metal complex formation of the BODIPY carboxylic acid ligands was investigated with the divalent metal ions of copper and rhodium. Copper forms insoluble material, which crystallized in one case. The X‐ray crystallographic analysis shows the presence of a BODIPY‐appended paddle wheel complex with typical Cu···Cu and Cu–O distances and four BODIPY units in a distance of 9.681 Å and 9.747 Å from the dinuclear center. Treatment with donor solvents results in the decomposition/monomerization of the compound, which could be shown crystallographically for pyridine. Rhodium(II) ions form soluble paddle wheel complexes with four different BODIPY carboxylates. The crystallographic analysis of one example shows the isostructural nature of the dirhodium and the dicopper derivatives. Optical spectroscopy and cyclic voltammetry provide first insights into efficient intramolecular energy‐ and electron transfer pathways for the rhodium complexes.
Synthesis, Crystal Structures, and Fluorescent Properties of Two ZnII/CdII Coordination Polymers Constructed from Isomeric Ligands
Authors: Xia Liang , Dong Wenwen , Tang Ping , Zhao Jun , Li Dongsheng 
Published: November 2015

AbstractThe d10 coordination polymers (CPs), [Zn(L1)(OH)]n (1) and [Cd(L2)2]n (2) were obtained from isomeric ligands 3‐(6‐aminpyridinium‐3‐yl) benzoic acid (L1) and 4‐(6‐aminpyridinium‐3‐yl) benzoic acid (L2), and characterized by elemental analyses, IR spectroscopy, single‐crystal and powder X‐ray diffraction. In compound 1, a spiral chain structure connected by μ2‐OH– and the ZnII ions, which are further linked by the L1 ligands to give atwo‐dimensional layered structure. Classical hydrogen‐bonding interactions (O···H–N) between adjacent layers result in three‐dimensional supramolecular structure. Compound 2 features a three‐dimensional framework formed by linking [Cd2(COO)2] clusters in a bcu net. Thermal stabilities and fluorescent properties of 1 and 2 were also investigated.
Paternalistic Leadership, Team Conflict, and TMT Decision Effectiveness: Interactions in the Chinese Context
Authors: Chen Lu , Yang Baiyin , Jing Runtian 
Published: November 2015

ABSTRACTIn this article, we propose that types of CEO paternalistic leadership will affect the effectiveness of top management team (TMT) decisions, and that team conflict will play a mediating role in the relationship between CEO paternalistic leadership and decision effectiveness in the Chinese context. Data collected from 108 TMTs in China suggest that dimensions of paternalistic leadership significantly affect decision effectiveness: benevolent and moral leadership positively affect TMT decision effectiveness, but authoritarian leadership has negative effects on TMT decision effectiveness. In addition, cognitive and affective team conflicts partially mediate the links between paternalistic leadership types and decision effectiveness. The results suggest that CEO paternalistic leadership approaches and conflict modes significantly determine TMT decision effectiveness.
Changes in milk composition in obese rats consuming a high-fat diet
Authors: Bautista C. J. , Montaño S. , Ramirez V. , Morales A. , Nathanielsz P. W. , Bobadilla N. A. , Zambrano E. 
Published: November 2015

AbstractMaternal obesity programmes offspring development. We addressed maternal obesity effects induced by high-fat diets on maternal mammary gland (MG) structure and function and offspring brain, liver and fat outcomes. Mothers were fed control (C, n 5) or obesogenic (MO, n 5) diet from the time they were weaned through pregnancy beginning at 120 d, through lactation. At offspring postnatal day (PND) 20, milk leptin and nutrients were determined. At the end of lactation, maternal liver and MG fatty acid profile were measured. Desaturase (Δ6D and Δ5D) and elongase (ELOVL 5 and ELOVL 2) protein was measured by immunohistochemistry and Western blotting (WB) in the liver and WB in the MG. In mothers, liver, MG and milk fat content were higher in MO than in C. Liver arachidonic acid (AA) and EPA and MG EPA were lower in MO than in C. Liver desaturases were higher in MO. The MG was heavier in MO than in C, with decreased Δ5D expression in MO. Desaturases and elongases were immunolocalised in parenchymal cells of both groups. Milk yield, water, carbohydrate content, EPA and DHA were lower, whereas milk leptin and AA were higher in MO than in C. At PND 21 and 36, brain weight was less and fat depots were greater in MO offspring than in C. MO decreased male absolute brain weight but not female absolute brain weight. In conclusion, maternal obesity induced by an obesogenic diet negatively affects maternal liver and MG function with the production of significant changes in milk composition. Maternal obesity adversely affects offspring metabolism and development.
Type D personality, anxiety, depression and personality traits in patients with isolated itching of the external auditory canal
Authors: Yilmaz B , Canan F , Şengül E , Özkurt F E , Tuna S F , Yildirim H 
Published: November 2015

AbstractObjective:This study evaluated type D personality, anxiety, depression and personality traits in patients with isolated itching of the external auditory canal.Method:A hundred consecutive out-patients with isolated itching of the external auditory canal and 100 controls were enrolled in the study. The Type D Scale, the abbreviated form of the Eysenck Personality Questionnaire Revised and the Hospital Anxiety and Depression Scale were used for data collection. Patients were also evaluated using the Modified Itch Severity Scale.Results:In all, 43 per cent of patients and 15 per cent of controls met the criteria for a type D personality. Patients with a type D personality had higher anxiety and itching severity but lower extraversion compared with those without a type D personality. Multiple linear regression analysis showed that extraversion and type D personality were independently associated with itch severity.Conclusion:These data suggest that clinicians should consider psychological and personality features when evaluating and treating patients with isolated itching of the external auditory canal.
Introducing a realistic and reusable quinsy simulator
Authors: Giblett N , Hari C 
Published: November 2015

AbstractBackground:An increasing number of inexperienced doctors are rotating through otolaryngology departments and providing care to ENT patients. Numerous acute ENT conditions require basic surgical or technical intervention; hence, effective and efficient simulation induction training has become paramount in providing a safe yet valuable educational environment for the junior clinician. Whilst simulation has developed over the years for numerous ENT skills, to date there has not been a realistic and easily reproducible model for teaching the skills to manage one of the most common ENT emergencies, a peritonsillar abscess or ‘quinsy’.Method:We have adapted the Laryngotech trainer, a well-established ENT simulation tool, to present a readily accessible, reusable and realistic simulation model.Conclusion:The model provides safe training for the drainage of quinsy.
Displacement, disempowerment and corruption: challenges at the interface of fisheries, management and conservation in the Bijagós Archipelago, Guinea-Bissau
Authors: Cross Helen 
Published: November 2015

AbstractSmall-scale fishers working in the West African Bijagós Archipelago are predominantly regional in-migrants, often living in isolated fishing camps (or economic enclaves) where capture, processing and trading activities occur. This paper explores the factors driving the fishing camp formation, relations with non-camp communities and interactions with prominent authority groups. One camp, presented here in the context of an anthropological case study, lost access to Ancopado beach during the designation of Orango National Park. Following violent evictions, migrant fishers shifted their efforts into less-observed waters, introducing challenging power negotiations with indigenous Bijagós islanders and fisheries authorities. Fishing persists inside the marine protected area, indicative of non-compliance by small-scale fishers who continue to resist a weak resource management agenda. The implications of this situation are discussed in terms of human rights to fish.
Stereotype or grammar? The representation of gender when two-year-old and three-year-old French-speaking toddlers listen to role nouns
Authors: LÉVY ARIK , GYGAX PASCAL , GABRIEL UTE , ZESIGER PASCAL 
Published: November 2015

AbstractUsing a preferential looking paradigm, the current study examined the role that grammatical gender plays when preschool French-speaking toddlers process role nouns in the masculine form (e.g.,chanteursmasculine‘singers’). While being auditorily prompted with “Look at the ‘a role noun’!”, two- and three-year-olds were presented with two pictures of two characters (‘boy–boy’ versus ‘girl–boy’) with attributes of the given role noun (e.g., singers with microphone and music notes). All role nouns were presented in the masculine plural form, which, despite its use to refer to mixed-gender groups, can be interpreted as referring to men. We expected toddlers to be biased by stereotypes, yet when non-stereotypical role nouns were presented, toddlers were not influenced by grammatical gender, but by their own sex (even more so for three-year-old toddlers). The absence of sensitivity to grammatical cues for either age group is discussed in terms of the developmental awareness of grammatical gender.
Epidemiology and factors associated with candidaemia following Clostridium difficile infection in adults within metropolitan Atlanta, 2009–2013
Authors: VALLABHANENI S. , ALMENDARES O. , FARLEY M. M. , RENO J. , SMITH Z. T. , STEIN B. , MAGILL S. S. , SMITH R. M. , CLEVELAND A. A. , LESSA F. C. 
Published: November 2015

SUMMARYWe assessed prevalence of and risk factors for candidaemia following Clostridium difficile infection (CDI) using longitudinal population-based surveillance. Of 13 615 adults with CDI, 113 (0·8%) developed candidaemia in the 120 days following CDI. In a matched case-control analysis, severe CDI and CDI treatment with vancomycin + metronidazole were associated with development of candidaemia following CDI.
Converting treaties into tactics on military operations
Authors: Carswell Andrew J. 
Published: November 2015

AbstractDespite widespread State acceptance of the international law governing military use of force across the spectrum of operations, the humanitarian reality in today's armed conflicts and other situations of violence worldwide is troubling. The structure and incentives of armed forces dictate the need to more systematically integrate that law into operational practice. However, treaty and customary international law is not easily translated into coherent operational guidance and rules of engagement (RoE), a problem that is exacerbated by differences of language and perspective between the armed forces and neutral humanitarian actors with a stake in the law's implementation. The author examines the operative language of RoE with a view to facilitating the work of accurately integrating relevant law of armed conflict and human rights law norms. The analysis highlights three crucial debates surrounding the use of military force and their practical consequences for operations: the dividing line between the conduct of hostilities and law enforcement frameworks, the definition of membership in an organized armed group for the purpose of lethal targeting, and the debate surrounding civilian direct participation in hostilities and the consequent loss of protection against direct attack.
MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail
Authors: Zuo Q-F , Cao L-Y , Yu T , Gong L , Wang L-N , Zhao Y-L , Xiao B , Zou Q-M 
Published: November 2015

AbstractMicroRNAs (miRNAs) deregulation is frequent in human gastric cancers (GCs), but the role of specific miRNAs involved in this disease remains elusive. MiR-22 was previously reported to act as tumor suppressors or oncogenes in diverse cancers. However, their accurate expression, function and mechanism in GC are largely unclear. Here, we found that the expression of miR-22 was significantly reduced in clinical GC tissues compared with paired adjacent normal tissues, and was significantly correlated with a more aggressive phenotype of GC in patients, and miR-22 low expression correlated with poor overall survival. The introduction of miR-22 markedly suppressed GC cell growth, migration and invasion, and inhibition of miR-22 promoted GC cell proliferation, migration and invasion in vitro. We further demonstrated that miR-22 acted as tumor suppressors through targeting extracellular matrix (ECM) remodeling member matrix metalloproteinase 14 (MMP14) and epithelial-to-mesenchymal transition (EMT) inducer Snail in GC. Moreover, ectopic expression of MMP14 or Snail restored inhibitory effects of miR-22 on cell migration and invasion in GC cells, and a negative relationship between the miR-22 expression and MMP14 or Snail mRNA levels was observed in GC. Finally, overexpression of miR-22 suppressed tumor growth, peritoneal dissemination and pulmonary metastasis in vivo. Taken together, we identified that miR-22 is a potent tumor suppressor in GC. MiR-22 downregulation promotes GC invasion and metastasis by upregulating MMP14 and Snail, and then inducing ECM remodeling and EMT. These findings provide a better understanding of the development and progression of GC and may be an important implication for future therapy of the GC.
In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-XL and Mcl-1 but in the absence of active BH3-only proteins
Authors: Senft D , Weber A , Saathoff F , Berking C , Heppt M V , Kammerbauer C , Rothenfusser S , Kellner S , Kurgyis Z , Besch R , Häcker G 
Published: November 2015

AbstractMitochondrial apoptosis is controlled by proteins of the B-cell lymphoma 2 (Bcl-2) family. Pro-apoptotic members of this family, known as BH3-only proteins, initiate activation of the effectors Bcl-2-associated X protein (Bax) and Bcl-2 homologous antagonist/killer (Bak), which is counteracted by anti-apoptotic family members. How the interactions of Bcl-2 proteins regulate cell death is still not entirely clear. Here, we show that in the absence of extrinsic apoptotic stimuli Bak activates without detectable contribution from BH3-only proteins, and cell survival depends on anti-apoptotic Bcl-2 molecules. All anti-apoptotic Bcl-2 proteins were targeted via RNA interference alone or in combinations of two in primary human fibroblasts. Simultaneous targeting of B-cell lymphoma-extra large and myeloid cell leukemia sequence 1 led to apoptosis in several cell types. Apoptosis depended on Bak whereas Bax was dispensable. Activator BH3-only proteins were not required for apoptosis induction as apoptosis was unaltered in the absence of all BH3-only proteins known to activate Bax or Bak directly, Bcl-2-interacting mediator of cell death, BH3-interacting domain death agonist and p53-upregulated modulator of apoptosis. These findings argue for auto-activation of Bak in the absence of anti-apoptotic Bcl-2 proteins and provide evidence of profound differences in the activation of Bax and Bak.
iJGVD: an integrative Japanese genome variation database based on whole-genome sequencing
Authors: Yamaguchi-Kabata Yumi , Nariai Naoki , Kawai Yosuke , Sato Yukuto , Kojima Kaname , Tateno Minoru , Katsuoka Fumiki , Yasuda Jun , Yamamoto Masayuki , Nagasaki Masao 
Published: November 2015

AbstractThe integrative Japanese Genome Variation Database (iJGVD; http://ijgvd.megabank.tohoku.ac.jp/) provides genomic variation data detected by whole-genome sequencing (WGS) of Japanese individuals. Specifically, the database contains variants detected by WGS of 1,070 individuals who participated in a genome cohort study of the Tohoku Medical Megabank Project. In the first release, iJGVD includes >4,300,000 autosomal single nucleotide variants (SNVs) whose minor allele frequencies are >5.0%.
Acute loss of TET function results in aggressive myeloid cancer in mice
Authors: An Jungeun , González-Avalos Edahí , Chawla Ashu , Jeong Mira , López-Moyado Isaac F. , Li Wei , Goodell Margaret A. , Chavez Lukas , Ko Myunggon , Rao Anjana 
Published: November 2015

AbstractTET-family dioxygenases oxidize 5-methylcytosine (5mC) in DNA, and exert tumour suppressor activity in many types of cancers. Even in the absence of TET coding region mutations, TET loss-of-function is strongly associated with cancer. Here we show that acute elimination of TET function induces the rapid development of an aggressive, fully-penetrant and cell-autonomous myeloid leukaemia in mice, pointing to a causative role for TET loss-of-function in this myeloid malignancy. Phenotypic and transcriptional profiling shows aberrant differentiation of haematopoietic stem/progenitor cells, impaired erythroid and lymphoid differentiation and strong skewing to the myeloid lineage, with only a mild relation to changes in DNA modification. We also observe progressive accumulation of phospho-H2AX and strong impairment of DNA damage repair pathways, suggesting a key role for TET proteins in maintaining genome integrity.
Giant barocaloric effects at low pressure in ferrielectric ammonium sulphate
Authors: Lloveras P. , Stern-Taulats E. , Barrio M. , Tamarit J.-Ll. , Crossley S. , Li W. , Pomjakushin V. , Planes A. , Mañosa Ll. , Mathur N. D. , Moya X. 
Published: November 2015

AbstractCaloric effects are currently under intense study due to the prospect of environment-friendly cooling applications. Most of the research is centred on large magnetocaloric effects and large electrocaloric effects, but the former require large magnetic fields that are challenging to generate economically and the latter require large electric fields that can only be applied without breakdown in thin samples. Here we use small changes in hydrostatic pressure to drive giant inverse barocaloric effects near the ferrielectric phase transition in ammonium sulphate. We find barocaloric effects and strengths that exceed those previously observed near magnetostructural phase transitions in magnetic materials. Our findings should therefore inspire the discovery of giant barocaloric effects in a wide range of unexplored ferroelectric materials, ultimately leading to barocaloric cooling devices.