bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary supplement use in the older population of Iceland and association with mortality
Authors: Ólafsdóttir Birta , Gunnarsdóttir Ingibjörg , Nikulásdóttir Hjálmfríður , Eiríksdóttir Guðný , Harris Tamara B. , Launer Lenore J. , Guðnason Vilmundur , Halldórsson Thórhallur I. , Einarsdóttir Kristjana 
Published: June 2017

AbstractDietary supplements are often used by the elderly to improve their nutritional status. However, intake above the recommended dietary levels may be detrimental, and uncertainty exists on the potential health benefits of supplementation in this population. The aim of this study was to describe supplement use among Icelandic older adults and to assess its association with total mortality and CVD-related mortality. This study used data from the Age Gene/Environment Susceptibility-Reykjavik study, which recruited 5764 participants aged 66–98 years in 2002–2006. Intake of vitamins and minerals from dietary supplements was estimated from interviews. Hazard ratios (HR) for mortality were estimated in multivariate analyses with follow-up ending in 2009. The results showed that most (77 %) of the participants used supplements. Overall, the consumption of vitamins and minerals from supplements was moderate although 22 and 14 % of users exceeded the upper recommended intake levels for vitamin B6 and Zn, respectively. Supplement users followed in general a healthier lifestyle than non-users. There were 1221 deaths including 525 CVD-related deaths during the follow-up period. When comparing multivitamin users with non-users in multivariable models, no associations with total mortality (HR 0·91; 95 % CI: 0·77, 1·08) or CVD-related mortality (HR 0·91; 95 % CI 0·70, 1·18) were observed. In conclusion, users of supplements generally lead healthier lifestyles than non-users and supplements did not confer any added advantage or harm relative to mortality risk. However, the intake of vitamin B6 and Zn from dietary supplements exceeded the recommended daily intake for almost a quarter of the supplement users.
Distribution and formation of particles produced by laser ablation of cyclotetramethylene tetranitramine
Authors: Zhang W. , Shen R. , Ye Y. , Wu L. , Zhu P. , Hu Y. 
Published: June 2017

AbstractAn experimental investigation into laser ablation of secondary explosives, cyclotetramethylene tetranitramine (HMX), has been carried out by using a solid-state laser at the wavelength of 1064 nm. The ion particles of decomposition were detected by using a time-of-flight mass spectrometer. Possible attributions of both negative ions and positive ions were obtained. Some obvious peaks were found atm/z= 18, 28, 46, 60, and 106, corresponding to H2O, CO/N2/H2CN, NO2, CH2NO2/N2O2, and N(NO2)2/CH2(NO2)2, respectively. According to the distribution of the particles, three possible pathways were proposed to explain the process of particles. The results may shed some light on the possible decomposition mechanism of HMX under laser initiation.
Significance of the localization of phosphorus among tissues on a cross-section of leaf lamina of Bornean tree species for phosphorus-use efficiency
Authors: Tsujii Yuki , Oikawa Masakazu , Kitayama Kanehiro 
Published: June 2017

Abstract:A greater relative allocation of phosphorus (P) to photosynthetically active cells functions to maintain a rapid photosynthesis under P limitation, and may be a key mechanism of plants to use P efficiently. This mechanism has not been studied in tropical trees despite the productivity of tropical forests often being limited by P. In this study, the spatial distribution of P among tissues on a cross-section of leaf lamina was analysed for 13 tree species from P-limited sites on Mount Kinabalu, Borneo. Most species showed greater P concentration in palisade mesophyll than in spongy mesophyll and epidermal tissues, suggesting that tropical trees under P limitation localize foliar P in photosynthetic palisade mesophyll.
Referential interactions of Turkish-learning children with their caregivers about non-absent objects: integration of non-verbal devices and prior discourse
Authors: ATEŞ BEYZA Ş. , KÜNTAY AYLİN C. 
Published: June 2017

AbstractThis paper examines the way children younger than two use non-verbal devices (i.e., deictic gestures and communicative functional acts) and pay attention to discourse status (i.e., prior mention vs. newness) of referents in interactions with caregivers. Data based on semi-naturalistic interactions with caregivers of four children, at ages 1;00, 1;05, and 1;09, are analyzed. We report that children employ different types of non-verbal devices to supplement their inadequate referential forms before gaining mastery in language. By age 1;09, children show sensitivity to discourse status by using deictic gestures to accompany their non-lexical forms for new referents. A comparison of children's patterns with those in the input they receive reveals that caregivers choose their referential forms in accordance with discourse status information and tend to use different types of non-verbal devices to accompany their lexical and non-lexical referential forms. These results show that non-verbal devices play an important role in early referential discourse.
Four-year-old Cantonese-speaking children's online processing of relative clauses: a permutation analysis
Authors: CHAN ANGEL , YANG WENCHUN , CHANG FRANKLIN , KIDD EVAN 
Published: June 2017

AbstractWe report on an eye-tracking study that investigated four-year-old Cantonese-speaking children's online processing of subject and object relative clauses (RCs). Children's eye-movements were recorded as they listened to RC structures identifying a unique referent (e.g. “Can you pick upthe horse that pushed the pig?”). Two RC types, classifier (CL) andge3RCs, were tested in a between-participants design. The two RC types differ in their syntactic analyses and frequency of occurrence, providing an important point of comparison for theories of RC acquisition and processing. A permutation analysis showed that the two structures were processed differently: CL RCs showed a significant object-over-subject advantage, whereasge3RCs showed the opposite effect. This study shows that children can have different preferences even for two very similar RC structures within the same language, suggesting that syntactic processing preferences are shaped by the unique features of particular constructions both within and across different linguistic typologies.
Impulsivity as a mechanism linking child abuse and neglect with substance use in adolescence and adulthood
Authors: Oshri Assaf , Kogan Steve M. , Kwon Josephine A. , Wickrama K. A. S. , Vanderbroek Lauren , Palmer Abraham A. , MacKillop James 
Published: June 2017

AbstractEmerging developmental perspectives suggest that adverse rearing environments promote neurocognitive adaptations that heighten impulsivity and increase vulnerability to risky behavior. Although studies document links between harsh rearing environments and impulsive behavior on substance use, the developmental hypothesis that impulsivity acts as mechanism linking adverse rearing environments to downstream substance use remains to be investigated. The present study investigated the role of impulsivity in linking child abuse and neglect with adult substance use using data from (a) a longitudinal sample of youth (Study 1,N= 9,421) and (b) a cross-sectional sample of adults (Study 2,N= 1,011). In Study 1, the links between child abuse and neglect and young adult smoking and marijuana use were mediated by increases in adolescent impulsivity. In Study 2, indirect links between child abuse and neglect and substance use were evidenced via delayed reward discounting and impulsivity traits. Among impulsivity subcomponents, robust indirect effects connecting childhood experiences to cigarette use emerged for negative urgency. Negative urgency, positive urgency, and sensation seeking mediated the effect of child abuse and neglect on cannabis and alcohol use. Results suggest that child abuse and neglect increases risk for substance use in part, due to effects on impulsivity. Individuals with adverse childhood experiences may benefit from substance use preventive intervention programs that target impulsive behaviors.
Clinical Information Transfer between EMS Staff and Emergency Medicine Assistants during Handover of Trauma Patients
Authors: Fahim Yegane Seyedeh Almas , Shahrami Ali , Hatamabadi Hamid Reza , Hosseini-Zijoud Seyed-Mostafa 
Published: June 2017

AbstractIntroductionClinical handover by Emergency Medical Services (EMS) staff, as the first people who have contact with trauma patients, in the emergency department (ED), is very important. Therefore, effective communication to transfer clinical information about patients in a concise, rational, clear, and time-bound manner is essential. In Iran, the transfer of necessary information in clinical handover in EDs was carried out orally and without following standard instructions. This study aimed to audit the current clinical handover according to the Identify, Situation, Background, Assessment, and Recommendation (ISBAR) tool and survey the effect of training the ISBAR tool to Emergency Medicine Assistants (EMAs) and EMS staff on improvement of the clinical handover of patients to the ED.MethodsThis is a clinical audit study in three phases in Imam Hossein Hospital (Tehran, Iran) during 2016. In the first phase, the clinical handover between EMS staff and EMAs for 178 trauma patients admitted to the ED using ISBAR was audited and information was recorded. In the second phase, the correct approach of clinical handover according to the ISBAR tool was taught to EMS staff and EMAs using pamphlets and lectures. In the third phase, again, the clinical handover between EMS staff and EMAs for 168 trauma patients admitted to the ED was audited using the ISBAR tool and information was recorded. At the end, clinical audit assessment indicators of handover were evaluated before and after training.ResultsClinical audit of the current situation in the ED showed that the clinical handover process does not follow standard ISBAR (0.0%). However, after training, 65.3% of clinical handover processes were performed in accordance with ISBAR. In the current study, there was an increase in all parameters of the ISBAR tool after training, most of which increased significantly compared to the first phase of the study (before the intervention).ConclusionsFindings demonstrate that patient handover in the ED did not initially follow the ISBAR standard guideline. After providing education as pamphlets and lectures to EMS staff and EMAs, a high percentage of patient handovers were conducted in accordance with the ISBAR instructions.Fahim YeganeSA,ShahramiA,HatamabadiHR,Hosseini-ZijoudSM.Clinical information transfer between EMS staff and Emergency Medicine Assistants during handover of trauma patients.Prehosp Disaster Med.2017;32(5):541–547.
Is Emotional Intelligence Impaired in Unaffected Siblings of Patients with Schizophrenia?
Authors: Frajo-Apor Beatrice , Kemmler Georg , Pardeller Silvia , Huber Markus , Macina Christian , Welte Anna-Sophia , Hofer Alex 
Published: June 2017

AbstractObjectives:Social cognitive deficits have been discussed to be endophenotypes for schizophrenia and other serious mental illnesses. The current study aimed to assess emotional intelligence (EI) in unaffected siblings of schizophrenia patients to investigate its potential role as endophenotype for schizophrenia.Methods:EI was measured in 56 schizophrenia patients, 57 unaffected siblings, and 127 healthy control subjects by using the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT). In addition, non-social cognition was assessed with the Brief Assessment of Cognition in Schizophrenia (BACS). Linear mixed models with compound symmetric correlation structure were used for of the three groups with respect to EI and non-social cognition.Results:Schizophrenia patients showed significantly lower overall EI and performed significantly worse in three out of four MSCEIT branches compared to unaffected siblings and control subjects, whereas the two latter groups had comparable EI levels. Similar performance patterns (patients<unaffected siblings=control subjects) were found with respect to non-social cognition. Solely in the “Tower of London” test, siblings achieved significantly lower task scores compared to control subjects.Conclusions:Based on our results, EI as measured with the MSCEIT does not seem to represent a marker of risk for schizophrenia. Further investigations should concentrate on other EI measures to reassess this finding. (JINS, 2017,23, 577–583)
Are the Dyson rings around pulsars detectable?
Authors: Osmanov Z. 
Published: June 2017

AbstractIn the previous paper ring (Osmanov 2016) (henceforth Paper-I) we have extended the idea of Freeman Dyson and have shown that a supercivilization has to use ring-like megastructures around pulsars instead of a spherical shell. In this work we reexamine the same problem in the observational context and we show that facilities of modern infrared (IR) telescopes (Very Large Telescope Interferometer and Wide-field Infrared Survey Explorer (WISE)) might efficiently monitor the nearby zone of the solar system and search for the IR Dyson-rings up to distances of the order of 0.2 kpc, corresponding to the current highest achievable angular resolution, 0.001 mas. In this case the total number of pulsars in the observationally reachable area is about 64 ± 21. We show that pulsars from the distance of the order of ~ 1 kpc are still visible for WISE as point-like sources but in order to confirm that the object is the neutron star, one has to use the ultraviolet telescopes, which at this moment cannot provide enough sensitivity.
UHRF1 is required for basal stem cell proliferation in response to airway injury
Authors: Xiang Handan , Yuan Lifeng , Gao Xia , Alexander Peter B , Lopez Omar , Lau Calvin , Ding Yi , Chong Mengyang , Sun Tao , Chen Rui , Liu Si-Qi , Wu Haiyang , Wan Ying , Randell Scott H , Li Qi-Jing , Wang Xiao-Fan 
Published: June 2017

AbstractCellular senescence is a cell fate characterized by an irreversible cell cycle arrest, but the molecular mechanism underlying this senescence hallmark remains poorly understood. Through an unbiased search for novel senescence regulators in airway basal cells, we discovered that the epigenetic regulator ubiquitin-like with PHD and ring finger domain-containing protein 1 (UHRF1) is critical for regulating cell cycle progression. Upon injury, basal cells in the mouse airway rapidly induce the expression of UHRF1 in order to stimulate stem cell proliferation and tissue repair. Targeted depletion of Uhrf1 specifically in airway basal cells causes a profound defect in cell cycle progression. Consistently, cultured primary human basal cells lacking UHRF1 do not exhibit cell death or differentiation phenotypes but undergo a spontaneous program of senescence. Mechanistically, UHRF1 loss induces G1 cell cycle arrest by abrogating DNA replication factory formation as evidenced by loss of proliferating cell nuclear antigen (PCNA) puncta and an inability to enter the first cell cycle. This proliferation defect is partially mediated by the p15 pathway. Overall, our study provides the first evidence of an indispensable role of UHRF1 in somatic stem cells proliferation during the process of airway regeneration.
Experimental study of thermal rectification in suspended monolayer graphene
Authors: Wang Haidong , Hu Shiqian , Takahashi Koji , Zhang Xing , Takamatsu Hiroshi , Chen Jie 
Published: June 2017

AbstractThermal rectification is a fundamental phenomenon for active heat flow control. Significant thermal rectification is expected to exist in the asymmetric nanostructures, such as nanowires and thin films. As a one-atom-thick membrane, graphene has attracted much attention for realizing thermal rectification as shown by many molecular dynamics simulations. Here, we experimentally demonstrate thermal rectification in various asymmetric monolayer graphene nanostructures. A large thermal rectification factor of 26% is achieved in a defect-engineered monolayer graphene with nanopores on one side. A thermal rectification factor of 10% is achieved in a pristine monolayer graphene with nanoparticles deposited on one side or with a tapered width. The results indicate that the monolayer graphene has great potential to be used for designing high-performance thermal rectifiers for heat flow control and energy harvesting.
Characterisation and comparison of bacterial communities on reverse osmosis membranes of a full-scale desalination plant by bacterial 16S rRNA gene metabarcoding
Authors: Nagaraj Veena , Skillman Lucy , Ho Goen , Li Dan , Gofton Alexander 
Published: June 2017

AbstractMicrobiomes of full-scale seawater reverse osmosis membranes are complex and subject to variation within and between membrane units. The pre-existing bacterial communities of unused membranes before operation have been largely ignored in biofouling studies. This study is novel as unused membranes were used as a critical benchmark for comparison. Fouled seawater reverse osmosis membrane biofilm communities from an array of autopsied membrane samples, following a 7-year operational life-span in a full-scale desalination plant in Western Australia, were characterised by 16S rRNA gene metabarcoding using the bacterial primers 515F and 806R. Communities were then compared based on fouling severity and sampling location. Microbiomes of proteobacterial predominance were detected on control unused membranes. However, fouled membrane communities differed significantly from those on unused membranes, reflecting that operational conditions select specific bacteria on the membrane surface. On fouled membranes, Proteobacteria were also predominant but families differed from those on unused membranes, followed by Bacteriodetes and Firmicutes. Betaproteobacteria correlated with stable, mature and thick biofilms such as those in severely fouled membranes or samples from the feed end of the membrane unit, while Alpha and Gammaproteobacteria were predominantly found in biofilms on fouled but visually clean, and moderately fouled samples or those from reject ends of membrane units. Gammaproteobacteria predominated the thin, compact biofilms at the mid-feed end of membrane units. The study also supported the importance of Caulobacterales and glycosphingolipid-producing bacteria, namely Sphingomonadales, Rhizobiales and Sphingobacteriia, in primary attachment and biofilm recalcitrance. Nitrate-and-nitrite-reducing bacteria such as Rhizobiales, Burkholderiales and some Pseudomonadales were also prevalent across all fouled membranes and appeared to be critical for ecological balance and biofilm maturation.
Replacing a Century Old Technique – Modern Spectroscopy Can Supplant Gram Staining
Authors: Berezin Shirly , Aviv Yaron , Aviv Hagit , Goldberg Elad , Tischler Yaakov R. 
Published: June 2017

AbstractRapid and accurate Gram differentiation is paramount as the first step of pathogen identification and antibiotics administration. However, the current method requires additional reagents, is time-consuming, and is operator dependent. Here we show the principle of tip enhanced Raman spectroscopy (TERS) can differentiate between Gram negative and positive species, by detecting the changes in tip-enhancement in the Raman scattering from the bacteria’s lipid-bilayer membrane, which specifically enhances Gram negative bacteria.
Overcoming evolved resistance to population-suppressing homing-based gene drives
Authors: Marshall John M. , Buchman Anna , Sánchez C. Héctor M. , Akbari Omar S. 
Published: June 2017

AbstractThe recent development of a CRISPR-Cas9-based homing system for the suppression of Anopheles gambiae is encouraging; however, with current designs, the slow emergence of homing-resistant alleles is expected to result in suppressed populations rapidly rebounding, as homing-resistant alleles have a significant fitness advantage over functional, population-suppressing homing alleles. To explore this concern, we develop a mathematical model to estimate tolerable rates of homing-resistant allele generation to suppress a wild population of a given size. Our results suggest that, to achieve meaningful population suppression, tolerable rates of resistance allele generation are orders of magnitude smaller than those observed for current designs for CRISPR-Cas9-based homing systems. To remedy this, we theoretically explore a homing system architecture in which guide RNAs (gRNAs) are multiplexed, increasing the effective homing rate and decreasing the effective resistant allele generation rate. Modeling results suggest that the size of the population that can be suppressed increases exponentially with the number of multiplexed gRNAs and that, with four multiplexed gRNAs, a mosquito species could potentially be suppressed on a continental scale. We also demonstrate successful proof-of-principle use of multiplexed ribozyme flanked gRNAs to induce mutations in vivo in Drosophila melanogaster – a strategy that could readily be adapted to engineer stable, homing-based drives in relevant organisms.
Alternative splicing regulates distinct subcellular localization of Epithelial splicing regulatory protein 1 (Esrp1) isoforms
Authors: Yang Yueqin , Carstens Russ P. 
Published: June 2017

AbstractEpithelial-Splicing-Regulatory-Protein 1 (Esrp1) is a cell-type specific RNA-binding protein (RBP) that is essential for mammalian development through maintenance of epithelial cell properties including barrier function. Esrp1 also regulates splicing during the epithelial to mesenchymal transition (EMT). It contains three highly conserved RNA recognition motifs (RRMs) in the absence of other clearly defined protein domains. Esrp1 itself is also alternatively spliced to produce multiple protein isoforms. Here we determined that two competing alternative 5′ splice sites in exon 12 yield Esrp1 isoforms with differential nucleocytoplasmic localization. We carried out a detailed characterization of the Esrp1 peptide that is sufficient to confer nuclear localization. Furthermore, we identified splice variants encoding distinct nuclear and cytoplasmic isoforms of fusilli, the D. Melanogaster Esrp1 ortholog. Our observations demonstrate that the production of both nuclear and cytoplasmic Esrp1 isoforms through alternative splicing is phylogenetically conserved; strongly suggesting it is biologically significant. Thus, while previous studies have described extensive regulation by nuclear Esrp1 to promote epithelial specific splicing, it will be of great interest to study the contribution of cytoplasmic Esrp1 in maintenance of epithelial cell functions.