bluuebunny/crossref_metadata_2025_split huggingface dataset:
Marked paraneoplastic basophilia accompanying eosinophilia in a cat with alimentary T-cell lymphoma
Authors: Balan Maria , Hope Aimee , Cassidy Joseph , McCullough Maureen , O’Brien Peter J 
Published: September 2017

Case summary A 5-year-old male neutered domestic shorthair cat was referred with a history of persistent pyrexia, pica, soft faeces, inappetence, intermittent vomiting, mild-to-moderate granulocytosis and mild hypercalcaemia. No significant improvement was noted after antibiotic and corticosteroid treatment, except that the hypercalcaemia resolved. Physical examination, including thoracic auscultation, and abdominal and peripheral lymph node palpation, were unremarkable. On admission, haematology revealed moderate leukocytosis (36.8 × 109/l) with moderate-to-marked eosinophilia (21.3 × 109/l) and marked basophilia (4.04 × 109/l), the latter identified microscopically. Lymphocytes were markedly decreased (0.37 × 109/l). Blood smear examination revealed 58% eosinophils, 28% neutrophils, 11% basophils, 2% monocytes, 1% lymphocytes and marked, diffuse platelet clumping. Biochemistry abnormalities indicated mild pancreatitis, dehydration and anorexia with mildly increased pancreatic lipase, mild hypernatraemia (157 mmol/l), a moderate decrease in urea (3.1 mmol/l) and a slight decrease in phosphate (1.32 mmol/l). Ultrasound and radiographic imaging revealed enlargement of the mesenteric lymph nodes. Fine-needle aspiration, a Tru-cut biopsy and immunohistochemistry were performed. Cytological examination revealed ~65–75% lymphocytes (~80% were larger than a neutrophil), ~25–35% eosinophils and occasional basophils. Lymphocytes had single, small (<1/3 red blood cells), prominent nucleoli and increased pale, mildly vacuolated cytoplasm. On histopathology, cells were monomorphic, large, with prominent nucleoli, and mild, multifocal, staining for T-cell marker CD3. Smaller cells were strongly CD3-positive. Cells were negative for B-cell marker CD45R. Relevance and novel information This is the most severe case of paraneoplastic basophilia reported with feline alimentary T-cell lymphoma with accompanying eosinophilia and lymph node infiltration. Feline basophil prevalence is reported for the first time.
Prevalence and severity of syndrome Z in women with metabolic syndrome on waiting list for bariatric surgery: a cross-sectional study
Authors: Perez Eduardo Araujo , Oliveira Luis Vicente Franco , Freitas Wilson Rodrigues , Malheiros Carlos Alberto , Ilias Elias Jirjoss , Silva Anderson Soares , Urbano Jessica Julioti , Oliveira Patricia Clemente , Cepeda Felipe X. , Sampaio Luciana M. M. , Trombetta Ivani C. , Delle Humberto , Neto Daniel Gianella , Nacif Sergio Roberto , Stirbulov Roberto 
Published: September 2017

Abstract
Background
In recent years, obesity has become one of the most important public health problems in the world, with a growing prevalence in both developed and developing countries. Recent studies show that sleep disturbances, especially obstructive sleep apnoea (OSA) may be a manifestation of metabolic syndrome (MetS). Although the association of OSA with the MetS is largely attributed to obesity, the exact pathophysiological mechanisms and their individual characteristics still need to be identified. This study investigated the prevalence and severity of syndrome Z in obese women with MetS on waiting list for bariatric surgery.

Methods
In this double-center cross-sectional study, female patients aged ≥18 years, stage III severe obesity with MetS, on waiting list for bariatric surgery were recruited. The diagnosis for MetS was made according to the criteria of the national cholesterol education program, adult treatment panel III. Clinical, anthropometric, demographic, biochemistry, and sleep measurements were collected. Correlations between continuous variables with sleep parameters were performed using the Pearson correlation test or Spearman correlation test.

Results
The mean age of 83 patients was 44.8 ± 11.2 years and mean BMI was 42.6 ± 8.1 kg/m2. There was a significant correlation between OSA and metabolic score (r = 0.336; P = 0.002), neck circumference (r = 0.218; P = 0.048), basal systolic blood pressure (r = 0.280; P = 0.01), total cholesterol (r = 0.277; P = 0.011) and abdomen circumference (r = 0.284; P = 0.009). The mean values of excessive daytime sleepiness were 10.5 ± 7 demonstrating a value considered normal for its presence. However, a high risk for OSA was observed in practically the entire population. It was observed that the prevalence of Syndrome Z (75.9%) increased significantly according to apnoea hypopnoea index (AHI) (P for trend <0.0000). A prevalence of 27.71% for mild OSA, 20.48% for moderate OSA, and 27.71% for severe OSA was observed. An association of AHI severity with all components of MetS was also observed.

Conclusions
We can conclude that syndrome Z presents a high prevalence in a female population with MetS and a considerable severity according to the presence of OSA. Therefore, patients with MetS should be investigated for the presence of sleep disorders.
Trial registration The study has been registered on ClinicalTrials.gov NCT02409160 and followed the standards of The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies
Acute reverse annular remodeling during MitraClip® therapy predicts improved clinical outcome in heart failure patients: a 3D echocardiography study
Authors: Herbrand Theresa , Eschenhagen Silke , Zeus Tobias , Kehmeier Eva , Hellhammer Katharina , Veulemans Verena , Kelm Malte , Balzer Jan 
Published: September 2017

Abstract
Background
Transcatheter mitral valve repair (TMVR) has been shown to have acute effects on mitral valve geometry in patients with functional mitral regurgitation (FMR). This study investigates the impact of MitraClip® therapy-induced annular remodeling on clinical outcome and mitral regurgitation in heart failure patients.

Methods
TMVR was performed successfully in 45 patients with FMR. In this study, mitral valve datasets were obtained before and directly after MitraClip® implantation using three-dimensional (3D) transesophageal echocardiography, and were analyzed offline retrospectively using dedicated 3D reconstruction software. Patients underwent clinical and echocardiographic evaluation at baseline and after 6 months. At follow-up, the patients were allocated into two groups according to their improvement in New York Heart Association (NYHA) functional class: a Low Responder group with ΔNYHA <1.5 (n = 25); and a High Responder group with ΔNYHA ≥1.5 (n = 20).

Results
At 6-month follow-up, data analysis revealed that while mitral regurgitation was reduced significantly in both groups, only the High Responder group had experienced significant downsizing of the 3D circumference (137 ± 14 mm to 126 ± 13 mm; p < 0.01) and the anterior-to-posterior diameter (33 ± 5 mm to 29 ± 4 mm; p < 0.01) of the mitral annulus during the intervention. Furthermore, only the High Responder group with reverse annular remodeling as shown had substantial advances in quality of life (Minnesota living with heart failure questionnaire: 55 ± 10 to 34 ± 14 points; p < 0.01) and functional status (6-min walk distance: 290 ± 104 m to 462 ± 111 m; p = 0.07).

Conclusion
Our study demonstrates that instantaneous left ventricular annular remodeling during MitraClip® implantation is associated with improved clinical outcome of heart failure patients with functional mitral regurgitation.
Trial registration The study was approved by the local ethics committee (Study Number 4497R, Registration ID: 2013121585). Trial registration: NCT02033811 Retrospectively registered January 9, 2014.
Determining the construction sequence of the Preah Vihear monument in Cambodia from its sandstone block characteristics
Authors: Uchida Etsuo , Mizoguchi Akinori , Sato Hiroya , Shimoda Ichita , Watanabe Ryota 
Published: September 2017

Abstract
The Preah Vihear monument in Cambodia, located close to the border with Thailand, was one of the Khmer temples registered on the UNESCO World Heritage List as a Cultural Property in 2008. It consists of masonry buildings constructed of siliceous sandstone blocks. In this study, the construction sequence of its buildings was inferred from the chemical composition, magnetic susceptibility, and size of the sandstone blocks, along with pediment end style, and the presence or absence of reliefs on the tympana of adjacent buildings. Five construction stages were identified. We revealed that the Western Annex Hall (N2) is the oldest edifice in the Preah Vihear monument. We also reconfirmed that the Preah Vihear monument was constructed over a range of years, spanning the Bakheng style period to the Angkor Wat style period (the end of the 9th century to the end of 12th century). It was clarified that during the construction of Preah Vihear, the style of pediment ends changed from pediments ending in scrolls made from one block, to pediments ending in scrolls made from two blocks, and finally to pediments ending in five-headed nagas. Over the same time span, the size of the sandstone blocks used in construction increased markedly.
Perturbed CD8+ T cell immunity across universal influenza epitopes in the elderly
Authors: Nguyen Thi H O , Sant Sneha , Bird Nicola L , Grant Emma J , Clemens E Bridie , Koutsakos Marios , Valkenburg Sophie A , Gras Stephanie , Lappas Martha , Jaworowski Anthony , Crowe Jane , Loh Liyen , Kedzierska Katherine 
Published: September 2017

Abstract
Influenza epidemics lead to severe illness, life-threatening complications, and deaths, especially in the elderly. As CD8+ T cells are associated with rapid recovery from influenza, we investigated the effects of aging on antigen-specific CD8+ T cells across the universal influenza epitopes in humans. We show that aging is characterized by altered frequencies in T cell subsets, with naive T cells being partially replaced by activated effector/memory populations. Although we observed no striking differences in TCR signaling capacity, T cells in the elderly had increased expression of transcription factors Eomes and T-bet, and such changes were most apparent in CD8+ T cells. Strikingly, the numbers of antigen-specific CD8+ T cells across universal influenza epitopes were reduced in the elderly, although their effector/memory phenotypes remained stable. To understand whether diminished numbers of influenza-specific CD8+ T cells in the elderly resulted from alteration in TCR clonotypes, we dissected the TCRαβ repertoire specific for the prominent HLA-A*02:01-restricted-M158–66 (A2/M158) influenza epitope. We provide the first ex vivo data on paired antigen-specific TCRαβ clonotypes in the elderly, showing that influenza-specific A2/M158+ TCRαβ repertoires in the elderly adults varied from those in younger adults, with the main features being a reduction in the frequency of the public TRAV27–TRBV19 TCRαβ clonotype, increased proportion of private TCRαβ signatures, broader use of TRAV and TRBV gene segments, and large clonal expansion of private TCRαβ clonotypes with longer CDR3 loops. Our study supports the development of T cell-targeted influenza vaccines that would boost the T cell compartment during life and maintain the numbers and optimal TCRαβ signatures in the elderly.
SIMPLIFY-1: A Phase III Randomized Trial of Momelotinib Versus Ruxolitinib in Janus Kinase Inhibitor–Naïve Patients With Myelofibrosis
Authors: Mesa Ruben A. , Kiladjian Jean-Jacques , Catalano John V. , Devos Timothy , Egyed Miklos , Hellmann Andrzei , McLornan Donal , Shimoda Kazuya , Winton Elliott F. , Deng Wei , Dubowy Ronald L. , Maltzman Julia D. , Cervantes Francisco , Gotlib Jason 
Published: September 2017

Purpose We evaluated the efficacy and safety of momelotinib, a potent and selective Janus kinase 1 and 2 inhibitor (JAKi), compared with ruxolitinib, in JAKi-naïve patients with myelofibrosis. Patients and Methods Patients (N = 432) with high risk or intermediate-2 risk or symptomatic intermediate-1 risk myelofibrosis were randomly assigned to receive 24 weeks of treatment with momelotinib 200 mg once daily or ruxolitinib 20 mg twice a day (or per label), after which all patients could receive open-label momelotinib. The primary end point was a ≥ 35% reduction in spleen volume at 24 weeks of therapy. Secondary end points were rates of symptom response and effects on RBC transfusion requirements. Results A ≥ 35% reduction in spleen volume at week 24 was achieved by a similar proportion of patients in both treatment arms: 26.5% of the momelotinib group and 29% of the ruxolitinib group (noninferior; P = .011). A ≥ 50% reduction in the total symptom score was observed in 28.4% and 42.2% of patients who received momelotinib and ruxolitinib, respectively, indicating that noninferiority was not met ( P = .98). Transfusion rate, transfusion independence, and transfusion dependence were improved with momelotinib (all with nominal P ≤ .019). The most common grade ≥ 3 hematologic abnormalities in either group were thrombocytopenia and anemia. Grade ≥ 3 infections occurred in 7% of patients who received momelotinib and 3% of patients who received ruxolitinib. Treatment-emergent peripheral neuropathy occurred in 10% of patients who received momelotinib (all grade ≤ 2) and 5% of patients who received ruxolitinib (all grade ≤ 3). Conclusion In JAKi-naïve patients with myelofibrosis, 24 weeks of momelotinib treatment was noninferior to ruxolitinib for spleen response but not for symptom response. Momelotinib treatment was associated with a reduced transfusion requirement.
Neuropeptidergic integration of behavior in Trichoplax adhaerens, an animal without synapses
Authors: Senatore Adriano , Reese Thomas S. , Smith Carolyn L. 
Published: September 2017

ABSTRACT
Trichoplax adhaerens is a flat, millimeter-sized marine animal that adheres to surfaces and grazes on algae. Trichoplax displays a repertoire of different feeding behaviors despite the apparent absence of a true nervous system with electrical or chemical synapses. It glides along surfaces to find food, propelled by beating cilia on cells at its ventral surface, and pauses during feeding by arresting ciliary beating. We found that when endomorphin-like peptides are applied to an animal, ciliary beating is arrested, mimicking natural feeding pauses. Antibodies against these neuropeptides label cells that express the neurosecretory proteins and voltage-gated calcium channels implicated in regulated secretion. These cells are embedded in the ventral epithelium, where they comprise only 4% of the total, and are concentrated around the edge of the animal. Each bears a cilium likely to be chemosensory and used to detect algae. Trichoplax pausing during feeding or spontaneously in the absence of food often induce their neighbors to pause as well, even neighbors not in direct contact. Pausing behavior propagates from animal to animal across distances much greater than the signal that diffuses from just one animal, so we presume that the peptides secreted from one animal elicit secretion from nearby animals. Signal amplification by peptide-induced peptide secretion explains how a small number of sensory secretory cells lacking processes and synapses can evoke a wave of peptide secretion across the entire animal to globally arrest ciliary beating and allow pausing during feeding.
From where to what: a neuroanatomically based evolutionary model of the emergence of speech in humans
Authors: Poliva Oren 
Published: September 2017

In the brain of primates, the auditory cortex connects with the frontal lobe via the temporal pole (auditory ventral stream; AVS) and via the inferior parietal lobe (auditory dorsal stream; ADS). The AVS is responsible for sound recognition, and the ADS for sound-localization, voice detection and integration of calls with faces. I propose that the primary role of the ADS in non-human primates is the detection and response to contact calls. These calls are exchanged between tribe members (e.g., mother-offspring) and are used for monitoring location. Detection of contact calls occurs by the ADS identifying a voice, localizing it, and verifying that the corresponding face is out of sight. Once a contact call is detected, the primate produces a contact call in return via descending connections from the frontal lobe to a network of limbic and brainstem regions.Because the ADS of present day humans also performs speech production, I further propose an evolutionary course for the transition from contact call exchange to an early form of speech. In accordance with this model, structural changes to the ADS endowed early members of the genusHomowith partial vocal control. This development was beneficial as it enabled offspring to modify their contact calls with intonations for signaling high or low levels of distress to their mother. Eventually, individuals were capable of participating in yes-no question-answer conversations. In these conversations the offspring emitted a low-level distress call for inquiring about the safety of objects (e.g., food), and his/her mother responded with a high- or low-level distress call to signal approval or disapproval of the interaction. Gradually, the ADS and its connections with brainstem motor regions became more robust and vocal control became more volitional. Speech emerged once vocal control was sufficient for inventing novel calls.
Beyond the Startup Stage: The Founding Team’s Human Capital, New Venture’s Stage of Life, Founder–CEO Duality, and Breakthrough Innovation
Authors: Tzabbar Daniel , Margolis Jaclyn 
Published: September 2017

Using a unique longitudinal study of U.S. biotechnology ventures, we advance extant research by showing that a founding team’s educational heterogeneity and prior founding experience have a positive and significant effect on the likelihood of a firm’s creating breakthrough innovation. However, we demonstrate that these relationships depend on the firm’s stage of life and decision-making structure as reflected in its founder–CEO duality. Specifically, we show that the positive effect of a founding team’s human capital is stronger in the growth stage than the early stages of a startup. While founder–CEO duality increases the positive effect of the founding team’s human capital in the startup stage, during the growth stage, such a structure reduces the impact of the founding team’s human capital. Therefore, to fully appreciate the effect of human capital on a venture’s success in breakthrough innovation, we must consider both the firm’s stage of life and its decision-making structure. As such, our theory provides a meeting ground for economists and organizational theorists on issues associated with human capital, founder’s power, the life cycle of new ventures, and technological entrepreneurship. The online appendix is available at https://doi.org/10.1287/orsc.2017.1152 .
Treatment of scapholunate ligament injury
Authors: Andersson Jonny K. 
Published: September 2017

Injuries to the scapholunate joint are the most common cause of carpal instability. An isolated injury to the scapholunate ligament may progress to abnormal joint mechanics and degenerative cartilage changes. Treatment for scapholunate instability is aimed at arresting the degenerative process by restoring ligament continuity and normalising carpal kinematics. Early arthroscopic diagnosis of scapholunate injury is mandatory for establishing the prognosis of the injury, as a proper ligament repair is recommended within four to six weeks after trauma. In this review, anatomy, diagnosis and treatment of scapholunate ligament injury and carpal instability are discussed. Recommendations for treatment based on the stage and classification of injury and the degree of instability and arthritic changes are proposed. Cite this article: EFORT Open Rev 2017;2:382–393. DOI: 10.1302/2058-5241.2.170016
T. C. Boyle’s The Harder They Come: Violence in America
Authors: Freese Peter 
Published: September 2017

AbstractT. C. Boyle’s fifteenth novel The Harder They Come (2015) offers a fictional inquiry into the American propensity for violence and takes its title from Jimmy Cliff’s 1972 reggae song and its motto from D. H. Lawrence’s characterization of the “essential American soul [as] hard, isolate, stoic, and a killer” (1978: 68). The article investigates how Boyle creates a metafictional historiography by combining two unrelated historical events – the bare-handed killing of a mugger by an elderly American veteran in Costa Rica and the long police hunt for the schizophrenic murderer Aaron Bassler in the Mendocino Redwoods – with a fictional character who represents the paranoid fringe worlds of sovereign citizens. The article then shows how Boyle embeds his plot in a general atmosphere of menace and incorporates the legend of the heroic mountain man John Colter, thus adding historical depth and evoking the world of wilderness survivalists. It also examines the narrative techniques, such as the choice of a schizophrenic’s point of view, and the stylistic features employed in order to fuse these ingredients into a thrilling tale that reveals the hidden relations between American foundation myths and the threats of contemporary gun violence.
The physicochemical properties of offal from Puławska gilts in relation to carcass meatiness
Authors: Babicz Marek , Kropiwiec Kinga , Szyndler-Nędza Magdalena , Skrzypczak Ewa 
Published: September 2017

Abstract
The aim of this study was to determine the relationship between the meatiness of the Puławska pig carcass and selected physical and chemical parameters of pork offal. The study was conducted on a group of 50 porkers of the native Puławska breed, whose carcasses were classified into five classes: E, U, R, O, and P, covering 10 specimens each. Samples were collected from the tongue, heart, lungs, liver and kidneys, and the pH (pH45, pH24), percentage of free water and chemical composition (ash, fat, protein) were determined. To summarise the obtained results, it can be concluded that the increase of the meat content in carcass significantly and primarily affects the reduction of the offal’s weight and then the reduction of the pH45 as well as the increase of the free water content primarily in the kidney and the lungs. In the case of chemical composition an increase of the meatiness in the carcass affected the reduction of fat content in the kidneys, lungs, heart and liver. The liver and the heart were the offal with the greatest susceptibility to the effects of the carcass meatiness. In this offal the increase of the carcass meatiness significantly decreased the fat content and energy value, and also increased the ash and protein content. Offal from the studied meatiness classes of the pigs’ carcasses was characterised by adequate quality and suitability for processing.
Diversity and gradients of vegetation of Sivrihisar Mountains (Eskişehir-Turkey)
Authors: Balpinar Neslihan , Kavgaci Ali , Bingöl M. Ümit , Ketenoğlu Osman 
Published: September 2017

AbstractThis study was carried out to determine the plant communities and understand the main topographical driving factors of floristic differentiation in the Sivrihisar Mountains (Eskişehir Province). Vegetation samplings were carried out according to the Braun-Blanquet approach. The relevés were stored in the TURBOVEG database management program. Hierarchical classification was carried out in PC-ORD program with Ward’s method and Euclidean distance as a resemblance measure. The diagnostic species were identified by a fidelity measure in the JUICE program. The results of the classification were visualized by ordination techniques in the CANOCO package by using principal component analysis. In conclusion, except for the degraded forest community, all the 7 steppe and 1 scrub plant communities studied were identified and described as new associations. Also, a syntaxonomical scheme for the vegetation of Sivrihisar Mountains was suggested.