bluuebunny/crossref_metadata_2025_split huggingface dataset:
Air pollutants and ovarian reserve: a systematic review of the evidence
Authors: Zupo Roberta , Castellana Fabio , Nawrot Tim S. , Lampignano Luisa , Bortone Ilaria , Murgia Ferdinando , Campobasso Gianluca , Gruszecka Kosowska Agnieskza , Giannico Orazio Valerio , Sardone Rodolfo 
Published: September 2024

BackgroundGrowing evidence indicates an association between ambient air pollution and decreased human reproductive potential. This study aims to systematically review the association between air pollutants and female ovarian reserve.MethodsThe literature was searched in six electronic databases through June 2024. Screening the 136 articles retrieved for inclusion criteria resulted in the selection of 15 human observational studies that evaluated the effect of environmental pollutants on ovarian reserve markers. The study protocol was registered on the International Prospective Register of Systematic Reviews (PROSPERO, registration code: CRD42023474218).ResultsThe study design of the selected studies was found to be cross-sectional (2 of 15), retrospective cohort (10 of 15), prospective cohort (2 of 15), and case–control (1 of 15). The study population was distributed as follows: Asians (53%, eight studies), Americans (33%, five studies), and Europeans (14%, two studies). The main findings showed a higher body of evidence for the environmental pollutants PM2.5, PM10, and NO2, while a low body of evidence for PM1, O3, SO2, and a very low body of evidence for benzene, formaldehyde, and benzo(a)pyrene, yet consistently showing significant inverse association data. The overall methodological quality of the selected studies was rated moderated across the 14 domains of the National Institutes of Health (NIH) toolkit.ConclusionThe data suggest that increased exposure to air pollutants seems to be associated with reduced ovarian reserve, with the most substantial evidence for pollutants such as PM2.5, PM10, and NO2. However, more evidence is needed to draw conclusions about causality.
Towards enhanced creativity in fashion: integrating generative models with hybrid intelligence
Authors: Ryjov Alexander , Kazaryan Vagan , Golub Andrey , Egorova Alina 
Published: September 2024

IntroductionThis study explores the role and potential of large language models (LLMs) and generative intelligence in the fashion industry. These technologies are reshaping traditional methods of design, production, and retail, leading to innovation, product personalization, and enhanced customer interaction.MethodsOur research analyzes the current applications and limitations of LLMs in fashion, identifying challenges such as the need for better spatial understanding and design detail processing. We propose a hybrid intelligence approach to address these issues.ResultsWe find that while LLMs offer significant potential, their integration into fashion workflows requires improvements in understanding spatial parameters and creating tools for iterative design.DiscussionFuture research should focus on overcoming these limitations and developing hybrid intelligence solutions to maximize the potential of LLMs in the fashion industry.
Fermented plant-based beverage supplemented with uvaia (Eugenia pyriformis) pulp: an innovative and pioneering approach to diversify plant-based diet product market
Authors: Santana de Oliveira Thaísa , Sant’Anna Roblessa , Arend Giordana Demaman , Sorita Guilherme Dallarmi , Camelo-Silva Callebe , Hoff Rodrigo Barcellos , Verruck Silvani 
Published: September 2024

Over the years, there has been an increase in demand for plant-based foods as alternatives. In line with this, this work explores the production and in vitro digestion of a fermented plant-based beverage (FPBB) produced with pea and rice proteins and 0% (FPBB-C), 5% (FPBB-5), and 10% (FPBB-10) uvaia pulp through lactic fermentation with Lacticaseibacillus rhamnosus GG. The in vitro gastrointestinal digestion process was conducted to assess the bioaccessibility of L. rhamnosus GG, total phenolic content (TPC), and antioxidant activity before and after simulating the gastrointestinal conditions. After 48 h of digestion, highly viable L. rhamnosus GG cells remained throughout the gastrointestinal system. FPBB-C (106.89%) and FPBB-5 (109.38%) exhibited higher survival rates than FPBB-10 (102.20%), indicating that these beverages have a higher prebiotic action potential. Compared with the non-digested samples, after 48 h of digestion, all samples exhibited a significant increase in TPC. The same behavior occurs for the antioxidant activity of FPBB-C, FPBB-5, and FPBB-10 by DPPH (4.06, 3.96, and 8.44 mg TEAC mL−1), ABTS (10.28, 11.06, 11.97 mg TEAC mL−1), and FRAP method (917.02, 863.87, and 1983.23 mg TEAC mL−1). Thirteen compounds were identified and quantified in uvaia pulp by HPLC-DAD-ESI-MS, particularly epigallocatechin gallate, quercetin-3-rhamnose, and quercetin-3-glucoside. Isorhamnetin was the main phenolic compound detected in the colon, assumably due to the conversion of quercetin-3-glucoside by the probiotic cells. In conclusion, as all counts were above 9 log CFU g−1, the FPBB formulations containing pea, rice protein, and uvaia pulp become a promising vehicle for carrying L. rhamnosus GG.
Leveraging single-cell transcriptomic data to uncover immune suppressive cancer cell subsets in triple-negative canine breast cancers
Authors: Kim Myung-Chul , Borcherding Nicholas , Song Woo-Jin , Kolb Ryan , Zhang Weizhou 
Published: September 2024

IntroductionSingle-cell RNA sequencing (scRNA-seq) has become an essential tool for uncovering the complexities of various physiological and immunopathological conditions in veterinary medicine. However, there is currently limited information on immune-suppressive cancer subsets in canine breast cancers. In this study, we aimed to identify and characterize immune-suppressive subsets of triple-negative canine breast cancer (TNBC) by utilizing integrated scRNA-seq data from published datasets.MethodsPublished scRNA-seq datasets, including data from six groups of 30 dogs, were subjected to integrated bioinformatic analysis.ResultsImmune modulatory TNBC subsets were identified through functional enrichment analysis using immune-suppressive gene sets, including those associated with anti-inflammatory and M2-like macrophages. Key immune-suppressive signaling, such as viral infection, angiogenesis, and leukocyte chemotaxis, was found to play a role in enabling TNBC to evade immune surveillance. In addition, interactome analysis revealed significant interactions between distinct subsets of cancer cells and effector T cells, suggesting potential T-cell suppression.DiscussionThe present study demonstrates a versatile and scalable approach to integrating and analyzing scRNA-seq data, which successfully identified immune-modulatory subsets of canine TNBC. It also revealed potential mechanisms through which TNBC promotes immune evasion in dogs. These findings are crucial for advancing the understanding of the immune pathogenesis of canine TNBC and may aid in the development of new immune-based therapeutic strategies.
Advancements in Cold-Region Rice Breeding: The 4S Phenotypic-Design Breeding System and Its Applications in Heilongjiang
Authors: Liu Baohai , Nie Shoujun , Gao Shiwei , Liu Qing , Liu Yuqiang , Mu Fengchen , Zhang Bo , Zhao Beiping , Gao Hongru , Wu Licheng , Xiao Minggang , Li Kun 
Published: September 2024

Heilongjiang, located in the cold region, is China’s largest rice-producing and commercializing province. The variety selection of rice in cold regions (RCR) is indispensable in promoting the rice industry’s development, and technological innovation in breeding theory plays a significant role in breeding breakthrough. Based primarily on long-term research, contemplation, and breeding practices, the 4S (selected topic, selected breeding, selected progenies, and selected promotion) phenotypic-design breeding technical system for RCR, which has revolutionized the theoretical basis and deepened the conceptual model, has been developed through systematic analyses and generalization. The system covers several key aspects such as scientific question formulation, breeding objective optimization, parental taxa hybridization, progeny population selection, and innovation dissemination, aiming to improve the foresight, precision, and efficiency of breeding. Furthermore, the system has demonstrated successful cases of rice variety breeding over the past 20 years, such as for Suijing 3, Suijing 4, Suijing 18, and a series of other rice varieties, providing theoretical and technical supports for cold-region rice breeding.
Continuity within a community integrated palliative care model and the influence of remote and digital approaches to care: a qualitative interview study
Authors: Ladds Emma , Ivey Malaika , Gadsby Katrina , Preest Elin , Samuels Ffion , Bradley Victoria 
Published: September 2024

BackgroundDemand for palliative care is rising. Recent UK policy approaches promote integrated care models — collaborations between GPs and multidisciplinary specialists — and remote and digital practices. The extent to which different forms of continuity are supported within this evolving context is currently unclear.AimTo explore the experience of continuity and impact of remote and digital practices within an integrated palliative care model.Design & settingA qualitative interview study of patients and bereaved relatives recruited from a GP practice list and healthcare professionals delivering the integrated palliative care service for that population.MethodTwenty narrative and semi-structured interviews were conducted with 22 patients, relatives, and professionals between May 2022 and November 2023. They explored how care was delivered or received, focusing on coherency and the use of remote and digital practices. Data were theorised using a novel framework that considered psychodynamic, biomedical, sociotechnical, and sociopolitical domains of continuity.ResultsThe need for human care and connection were of primary importance and affected by intersubjective, biomedical, sociotechnical, and sociopolitical factors that influenced continuity of care. Despite the logistical ease of remote and digital practices, professionals had to work harder or around technologies to provide a ‘caring’ service. This was exacerbated by a lack of co-localisation, loss of longitudinal relationships, and reduction in tacit knowledge.ConclusionNumerous complex factors and the exacerbating effects of remote and digital practices influence continuity and coherency within an integrated palliative care model.
CYCLIC DEPOSITS OF POTASH IN SASKATCHEWAN
Authors: Klingspor A. M. 
Published: September 2024

ABSTRACT
Exploration for hydrocarbons and potash in the Regina area has confirmed the presence of thick beds of sylvinitic potash ore. Mineralization is concentrated in three grouped intervals in the upper part of the Prairie Evaporite Formation of Middle Devonian age. Observed variations in composition, texture and fabric are believed to prove the primary nature of the ores discussed. The gross intervals, therefore, are interpreted to represent three major successive cycles of regression. Each major cycle is composed of numerous rhythms of deposition fluctuating from halite to sylvite, commonly commencing and ending with a small hiatus expressed by a fine clay lamina.
The ore in the lowermost potash beds has excellent industrial qualities where it combines high grade with low insoluble content and coarse crystallinity. The ores in the younger zones, although locally of high grade, are more contaminated by insolubles and have a finer crystal fabric.
THE UPPER DETACHMENT IN CONCENTRIC FOLDING
Authors: Dahlstrom C. D. A. 
Published: September 2024

ABSTRACT
During concentric folding the deformed rocks are divided into two or more discrete structural units. In the Fernie Basin area the internal structure and both boundaries of one concentrically folded panel can be studied. This structural-lithic unit is separated from the overlying rocks by a decollement and from the underlying rocks by a major thrust which probably was a decollement during folding. Recognizing these relationships requires the application of the principle of down-plunge projection.
A STUDY OF THE FOSSIL POLLEN WODEHOUSEIA SPINATA. I. ULTRASTRUCTURE AND COMPARISONS TO SELECTED MODERN TAXA. II. OPTICAL MICROSCOPIC RECOGNITION OF FOOT LAYERS IN DIFFERENTIALLY STAINED FOSSIL POLLEN AND THEIR SIGNIFICANCE
Authors: Leffingwell Harry A. , Larson Donald A. , Valencia Mark J. 
Published: September 2024

ABSTRACT
Pollen of Wodehouseia spiruita. Stanley, 1961, obtained from a sample of the Upper Cretaceous Lance Formation in east-central Wyoming, was studied with the scanning and transmission electron microscopes. The apertures and wall stratification indicate that Wodehouseia spinata is an angiospermous pollen. Its ektexine consists of a columella layer and a tectum, but lacks a foot layer; its endexine is a single, unstructured layer. The flange is formed entirely of ektexine, which separates from the endexine and protrudes in a narrow circumferential area about the grain. The flange surfaces are closely appressed, and supported internally by long, radiating projections which emerge through the tectum of the flange as small spines. The columella layer in the flange wall is reduced in height.
Although Wodehouseia is grossly similar to Impatiens, Beloperone, and Justicia, its ultrastructure is so fundamentally different as to render any generic relationships extremely improbable.
Fungsi Kognitif Skala MOCA-INA pada Peserta PPDS Anestesiologi dan Terapi Intensif: Perbandingan Sebelum dan Setelah Jaga di Rumah Sakit
Authors: Wonggo Tesalonika , Kambey Barry I. , Lalenoh Diana C. 
Published: September 2024

Abstract: Shift duty can negatively impact cognitive function among residents of Specialist Program. This study aimed to obtain the differences in cognitive function of Anesthesiology and Intensive Therapy (ATI) residents at Universitas Sam Ratulangi before and after on-call duty at Prof. Dr. R. D. Kandou General Hospital Manado. This was a descriptive observational study with a cross-sectional design. Samples were residents of ATI who completed the Indonesian version of the Montreal Cognitive Assessment (MoCA-INA) before and 24 hours after on-call duty. The results showed a total of 31 residents as samples with a proportion of 24 (77.4%) males and seven (22.6%) females. There was a decline in most cognitive domains, with a statistical analysis demonstrating a decrease in the mean MoCA-INA score from 26.8387 to 25.0000, accompanied by a p-value of 0.000 (<0.05) and a Z-score < -2 obtained from the Wilcoxon test. In conclusion, there is a significant difference in cognitive function of residents of Anesthesiology and Intensive Therapy Specialist Program of Universitas Sam Ratulangi before and after on-call duty at the hospital. This is possibly due to cognitive overload caused by the shift duty.
Keywords: cognitive function; MoCA-INA; shift duty; specialist program

Abstrak: Tugas jaga yang berat dapat berdampak negatif terhadap fungsi kognitif peserta Program Pendidikan Dokter Spesialis (PPDS). Penelitian ini bertujuan melihat perbedaan fungsi kognitif PPDS Anestesiologi dan Terapi Intensif (ATI) Universitas Sam Ratulangi sebelum dan sesudah jaga di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif observasional dengan desain potong-lintang pada PPDS ATI yang mengisi Montreal Cognitive Assesment versi Indonesia (MoCA-INA) sebelum dan 24 jam setelah jaga. Penelitian ini bertujuan untuk mengidentifikasi apakah terdapat perbandingan antara fungsi kognitif pada PPDS sebelum dan setelah menjalani tugas jaga 24 jam. Hasil penelitian mendapatkan 31 sampel dengan proporsi laki-laki sebanyak 24 (77,4%) orang dan perempuan sebanyak tujuh (22,6%) orang. Penurunan pada sebagian besar domain kognitif dengan hasil analisis statistik menunjukkan penurunan rerata skor MoCA-INA dari 26,8387 menjadi 25,0000 disertai dengan nilai p<0,05 (p=0,000) dan Z-score <-2 yang diperoleh melalui uji Wilcoxon. Simpulan penelitian ini ialah terdapat perbedaan fungsi kognitif PPDS Anestesiologi dan Terapi Intensif Universitas Sam Ratulangi yang bermakna antara sebelum dan setelah jaga di rumah sakit. Hal ini diduga disebabkan kelebihan beban kognitif akibat tugas jaga.
Kata kunci: fungsi kognitif; MoCA-INA; tugas jaga; residen pendidikan dokter spesialis
Health Promotion Using Dental Story Sticker Media on Prevention Knowledge Caries in Primary School
Authors: Budiman Angga Soleh Setia , Robbihi Hilmiy Ila , Primawati Rena Setiana 
Published: September 2024

Background: The results of basic health research in 2018 show that the biggest dental problem in Indonesia is broken/caved/sick teeth (45.3%). The proportion of problems with damaged, cavities or diseased teeth in Garut Regency is 57.61%. Health promotion is an effort to provide knowledge as a basis for behavior change to improve the health status of individuals, families, groups, and communities through learning activities. Dental Story Stickers are a way of conveying information about dental and oral health by using stickers that can be removed and reattached, as well as using storytelling as an outreach method where the instructor tells information about dental and oral health. Objective: To determine the effect of health promotion using dental story sticker media on knowledge of caries prevention in class IV students at State Elementary School 2 Mulyasari, Garut Regency. Method: The type of research is pre-experimental with a one-group pre and post-test design with total sampling technique, and measuring instruments namely questionnaires and statistical tests using the Wilcoxon test. Results: 18 students (60%) obtained good criteria, 12 students (40%) had sufficient criteria and no good curve criteria (0%). Conclusion: Health promotion using dental story sticker media influences knowledge of preventing dental caries in class IV students at State Elementary School 2 Mulyasari, Garut Regency.
Development Home Industry Culinary Sea-Processed Snacks Belitung District With Business Model Canvas
Authors: Rahmania Trisna 
Published: September 2024

This research aims to find out the condition of the culinary home industry for processed seafood snacks in Belitung Regency; factors that can influence the development of the seafood culinary snack home industry in Belitung Regency; and developing a culinary home industry for processed seafood snacks in Belitung Regency using the BMC (Business Model Canvas) method. The method used in this research is a qualitative descriptive method with data collection techniques through observation, interviews and literature studies with respondents from community-based culinary home industries, MSMEs, cooperatives, as well as domestic and foreign tourists in Belitung using the Business model canvas (BMC). The sampling technique was carried out using non-probability sampling using an incidental technique. The results of the research showed that there were five distribution areas for the Belitung seafood culinary snack home industry with cracker, chips or peanut brittle products. The factors that influence the development of processed seafood snacks are tourist visits, the tourism sector, and transportation, as well as tourist attraction factors based on culinary value, partners, promotions, online media, innovation, and competent people. BMC development is carried out through the identification of nine elements, namely (1) customer segments originating from domestic and foreign countries; (2) the value proposition comes from taste, distinctiveness and uniqueness; (3) key partners are the government, MSMEs, the Hospitality Industry, airlines, culinary entrepreneurs, bloggers and journalists; (4) customer relationships are the attraction of tourists because of promotions, taste, distinctiveness and uniqueness; (5) online media channels; (6) key activities are training, coaching, workshops, FGDs, exhibitions; (7) key resources come from the government, private sector and banking; (8) the cost structure is quite good; and (9) revenue streams contain good appreciation.
Hubungan Kadar CA-125 dengan Derajat Diferensiasi Kanker Ovarium Tipe Epithelial Tahun 2020 – 2022 di RSUD Abdul Wahab Sjahranie Samarinda
Authors: Diva Rahayu Diva Rahayu , Eko Nugroho  , Maulida Julia Saputri  
Published: September 2024

Kanker ovarium adalah tumor ganas, dengan tipe yang paling sering ditemukan yaitu ephitelial. CA-125 dan derajat diferensiasi penting untuk menentukan keganasan, dan prognosis penyakit kanker ovarium. Tujuan penelitian untuk mengetahui hubungan kadar CA-125 dengan derajat diferensiasi kanker ovarium tipe epithelial Tahun 2020 – 2022 di RSUD Abdul Wahab Sjahranie Samarinda. Sampel penelitian ini sebanyak 112 sampel data hasil pemeriksaan pasien kanker ovarium RSUD Abdul Wahab Sjahranie Samarinda tahun 2020-2022 dengan teknik Purposive Sampling. Jenis penelitian deskriptif analitik dengan pendekatan retrospektif. Analisis data dengan uji Chi square. Hasil penelitian didapatkan usia penderita kanker ovarium pada masa lansia awal (46-55 tahun) yaitu 46 pasien (41,1%). Paritas jenis multipara yaitu 45 pasien (40,3%). Hasil kadar CA-125 saat pertama kali diperiksa paling banyak meningkat (>35 U/mL) yaitu 69 pasien (61,6%). Sedangkan, derajat diferensiasi pasien terbanyak pada tingkat diferensiasi buruk yaitu 50 pasien (44,6%). Hasil perhitungan statistik, terdapat hubungan bermakna antara kada CA-125 dengan derajat diferensiasi p value <α(0,05) yaitu 0,042, sehingga dapat disimpulkan bahwa semakin tinggi kadar CA-125 semakin buruk diferensiasi sel kanker ovarium.
Strategi Penyiapan Aparat Komando Kewilayahan (Kowil) dalam Operasi Teritorial Pada Operasi Gabungan TNI di Wilayah Kodam II/Sriwijaya
Authors: Arif Abdillah 
Published: September 2024

This research aims to analyze the strategy for preparing Territorial Command Apparatus (Kowil) in territorial operations carried out by the Indonesian National Armed Forces (TNI) in the Kodam II/Sriwijaya region. The research employs a qualitative method with a case study approach, involving in-depth interviews, observations, and document analysis. The findings indicate that the strategies implemented include intensive training In the field of Territorial (Devotion to the Indonesian Armed Forces (Bhakti TNI), Social Communication (Komsos), and Regional Defense Training (Binwanwil)), enhancement of inter-agency cooperation, and the use of information technology to support communication and coordination. Additionally, community participation is considered crucial for the success of territorial operations. This study provides recommendations for further development in preparing Kowil apparatus in order to optimize their tasks and functions.