bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guidelines vs Actual Management of Skin and Soft Tissue Infections in the Emergency Department
Authors: Kamath Rahul S , Sudhakar Deepthi , Gardner Julianna G , Hemmige Vagish , Safar Hossam , Musher Daniel M 
Published: January 2018

AbstractBackgroundInfections of skin and soft tissue (SSTI) commonly cause visits to hospital emergency departments (EDs). The Infectious Diseases Society of America (IDSA) has published guidelines for the management of SSTI, but it is unclear how closely these guidelines are followed in practice.MethodsWe reviewed records of patients seen in the ED at a large tertiary care hospital to determine guidelines adherence in 4 important areas: the decision to hospitalize, choice of antibiotics, incision and drainage (I&D) of abscesses, and submission of specimens for culture.ResultsThe decision to hospitalize did not comply with guidelines in 19.6% of cases. Nonrecommended antibiotics were begun in the ED in 71% of patients with nonpurulent infections and 68.4% of patients with purulent infections. Abscesses of mild severity were almost always treated with antibiotics, and I&D was often not done (both against recommendations). Blood cultures were done (against recommendations) in 29% of patients with mild-severity cellulitis. Abscess drainage was almost always sent for culture (recommendations neither favor nor oppose). Overall, treatment fully complied with guidelines in 20.1% of cases.ConclusionsOur results show a striking lack of concordance with IDSA guidelines in the ED management of SSTI. Social factors may account for discordant decisions regarding site of care. Use of trimethoprim/sulfamethoxazole (TMP/SMX) in cellulitis was the most common source of discordance; this practice is supported by some medical literature. Excess antibiotics were often used in cellulitis and after I&D of simple abscesses, opposing antibiotic stewardship. Ongoing education of ED doctors and continued review of published guidelines are needed.
Tornadoes and Their Parent Convective Storms
Authors: Bluestein Howard B. 
Published: January 2018

Abstract
In the past four decades much has been discovered about tornado formation and structure from observations, laboratory models, and numerical-simulation experiments. Observations include nearby movies and photographs of tornadoes, fixed-site, airborne, and ground-based mobile Doppler radar remote measurements, and in situ measurements using instrumented probes. Laboratory models are vortex chambers and numerical-simulations are based on the governing fluid dynamical equations. However, questions remain: How and why do tornadoes form? and How does the wind field associated with them vary in space and time? Recent studies of tornadoes based on observations, particularly by radar, are detailed. The major aspects of numerically simulating a tornado and its formation are reviewed, and the dynamics of tornado formation and structure based on both observations and laboratory and numerical-simulation experiments are described. Finally, future avenues of research and suggested instrument development for furthering our knowledge are discussed.
Coastal Hazards, Risks, and Marine Extreme Events
Authors: Marone Eduardo , de Camargo Ricardo , Salcedo Castro Julio 
Published: January 2018

Abstract
This article describes the threat costal hazards pose to existing life in light of climate change and natural disaster. It includes an overview of flooding, extreme waves, and other water-related stressors. The article discusses how human-induced risks in the coastal zone, resulting from mismanaged urbanization, persistent pollution, and overexploitation of resources, exacerbate matters and pose extra pressure on the environment, science, and society. Ways of measurement and reaction to these events, as well as best practices for preparedness, are discussed. Businesses, individuals, and ecosystems are under threat of destruction from these circumstances. The article also emphasizes the need to make scientific work in this field accessible and understandable to society and decisión makers.
Hyperbaric Oxygen for Ischemia due to Injection of Cosmetic Fillers: Case Report and Issues
Authors: Henderson Raven , Reilly Debra A. , Cooper Jeffrey S. 
Published: January 2018

Summary:
Natural and synthetic fillers have revolutionized aesthetic facial rejuvenation and soft-tissue augmentation. We present a case highlighting the dangers of filler self-injection. A 37-year-old woman self-injected a dermal filler around both temples. She immediately experienced left--side hearing loss, blanching over the left face, and pain. Prompt treatment with hyaluronidase, topical nitro paste, and warm compresses ensued. An emergency computed tomography angiogram showed occlusion of a superficial temporal artery branch. We treated her with enoxaparin, aspirin, dexamethasone, piperacillin-tazobactam, and intradermal lidocaine. After 6 hyperbaric oxygen therapy (HBO2) treatments in 3 days, the patient showed improvement in appearance with markedly decreased ischemic discoloration and her hearing returned to baseline. Algorithms for treating such injuries generally neglect HBO2. HBO2 is thought to be efficacious in these situations by a variety of mechanisms: oxygenation of ischemic tissues, reduction of edema, amelioration of ischemic/reperfusion injury, promotion of angiogenesis and collagen maturation. Her resolved hearing highlights the utility of HBO2 in sudden hearing loss as well. Injectors should have guidelines for using product, not only on patients but staff as well. Filler courses should include handling complications and include HBO2 in their guidelines. Clinicians should remind patients to seek treatment from qualified clinicians. The goal of a bargain price using self-injection may quickly become expensive and disfiguring.
Effects of the Humanized Anti-Adrenomedullin Antibody Adrecizumab (HAM8101) on Vascular Barrier Function and Survival in Rodent Models of Systemic Inflammation and Sepsis
Authors: Geven Christopher , Peters Esther , Schroedter Mathias , Struck Joachim , Bergmann Andreas , McCook Oscar , Radermacher Peter , Kox Matthijs , Pickkers Peter 
Published: January 2018

ABSTRACT

Purpose:
Adrenomedullin (ADM) is an important regulator of endothelial barrier function during sepsis. Administration of a murine antibody targeted against the N-terminus of ADM (HAM1101) resulted in improved outcome in models of murine sepsis. We studied the effects of a humanized form of this antibody (HAM8101, also known as Adrecizumab) on vascular barrier dysfunction and survival in rodent models of systemic inflammation and sepsis.

Methods:
Rats (n=48) received different dosages of HAM8101 or placebo (n = 8 per group), directly followed by administration of lipopolysaccharide (5 mg/kg). Twenty-four hours later, Evans Blue dye was administered to assess vascular leakage in kidney and liver tissue. Furthermore, mice (n = 24) were administered different dosages of HAM8101 or placebo (n = 6 per group), immediately followed by cecal ligation and puncture (CLP). Eighteen hours later, albumin, vascular endothelial growth factor (VEGF), and angiopoietin-1 were analyzed in the kidney. Finally, effects of single and repeated dose administration of HAM1101, HAM8101 and placebo on survival were assessed in CLP-induced murine sepsis (n = 60, n = 10 per group).

Results:
Dosages of 0.1 and 2.5 mg/kg HAM8101 attenuated renal albumin leakage in endotoxemic rats. Dosages of 0.1, 2.0, and 20 mg/kg HAM8101 reduced renal concentrations of albumin and the detrimental protein VEGF in septic mice, whereas concentrations of the protective protein angiopoietin-1 were augmented. Both single and repeated administration of both HAM1101 and HAM8101 resulted in improved survival during murine sepsis.

Conclusions:
Pretreatment with the humanized anti-ADM antibody HAM8101 improved vascular barrier function and survival in rodent models of systemic inflammation and sepsis.
Data-driven approaches for Tau-PET imaging biomarkers in Alzheimer’s disease
Authors: Vogel Jacob W. , Mattsson Niklas , Iturria-Medina Yasser , Strandberg T. Olof , Schöll Michael , Dansereau Christian , Villeneuve Sylvia , van der Flier Wiesje M. , Scheltens Philip , Bellec Pierre , Evans Alan C. , Hansson Oskar , Ossenkoppele Rik ,   the Alzheimer’s Disease Neuroimaging Initiative,   the Swedish BioFINDER study
Published: January 2018

ABSTRACTPrevious positron emission tomography (PET) studies have quantified filamentous tau pathology using regions-of-interest (ROIs) based on observations of the topographical distribution of neurofibrillary tangles in post-mortem tissue. However, such approaches may not take full advantage of information contained in neuroimaging data. The present study employs an unsupervised data-driven method to identify spatial patterns of tau-PET distribution, and to compare these patterns to previously published “pathology-driven” ROIs. Tau-PET patterns were identified from a discovery sample comprised of 123 normal controls and patients with mild cognitive impairment or Alzheimer’s disease (AD) dementia from the Swedish BioFINDER cohort, who underwent [18F]AV1451 PET scanning. Associations with cognition were tested in a separate sample of 90 individuals from ADNI. BioFINDER [18F]AV1451 images were entered into a robust voxelwise stable clustering algorithm, which resulted in five clusters. Mean [18F]AV1451 uptake in the data-driven clusters, and in 35 previously published pathology-driven ROIs, was extracted from ADNI [18F]AV1451 scans. We performed linear models comparing [18F]AV1451 signal across all 40 ROIs to several tests of global cognition, adjusting for age, sex and education. Two data-driven ROIs consistently demonstrated the strongest or near-strongest effect sizes across all cognitive tests. Inputting all regions plus demographics into a feature selection routine resulted in selection of two ROIs (one data-driven, one pathology-driven) and education, which together explained 28% of the variance of a global cognitive composite score. Our findings suggest that [18F]AV1451-PET data naturally clusters into spatial patterns that are biologically meaningful and that may offer advantages as clinical tools.
Vascular risk factors for male and female urgency urinary incontinence at age 68 from a British birth cohort study
Authors: Tsui Alex , Kuh Diana , Cardozo Linda , Davis Daniel 
Published: January 2018

AbstractObjectiveTo investigate the prevalence of UUI at age 68 and the contribution of vascular risk factors to male and female UUI pathogenesis in addition to the associations with raised BMISubjects and methods1762 participants were from the MRC National Survey for Health and Development (NSHD) birth cohort, who answered the International Consultation on Incontinence Questionnaire short form (ICIQ-SF) at age 68. Logistic regression was used to estimate associations between UUI and earlier life vascular risk factors including: lipid status, diabetes, hypertension, body mass index (BMI), previous stroke or transient ischaemic attack (TIA) diagnosis; adjusting for smoking status, physical activity, co-presentation of SUI symptoms, educational attainment and in women only, type of menopause, age at period cessation and use of hormone replacement therapy.ResultsUUI was reported by 12% of men and 19% of women at 68. Female sex, previous stroke or TIA diagnosis, increased BMI and hypertension (in men only) at age 60-64 were independent risk factors for UUI. Female sex, increased BMI and a previous diagnosis of stroke/ TIA increased the relative risk of more severe UUI symptoms. Type and timing of menopause and HRT use did not alter the estimated associations between UUI and vascular risk factors in women.ConclusionMultifactorial mechanisms lead to UUI and vascular risk factors may contribute to pathogenesis of bladder overactivity in addition to higher BMI. Severe UUI appears to be a distinct presentation with more specific contributory mechanisms than milder UUI.
Factor Structure and Heritability of Obsessive-Compulsive Traits in Children and Adolescents in the General Population
Authors: Burton C.L. , Park L. S. , Corfield E. C. , Forget-Dubois N. , Dupuis A. , Sinopoli V. M. , Shan J. , Goodale T. , Shaheen S-M , Crosbie J. , Schachar R.J. , Arnold P.D 
Published: January 2018

ABSTRACTBackgroundObsessive-compulsive disorder (OCD) is a heritable childhood-onset psychiatric disorder that may represent the extreme of obsessive-compulsive (OC) traits that are widespread in the general population. We studied the factor structure and heritability of the Toronto Obsessive Compulsive Scale (TOCS), a new measure designed to assess traits associated with OCD in children and adolescents. We also examined the degree to which genetic effects are unique and shared between dimensions.MethodsOC traits were measured using the TOCS in 16,718 children and adolescents (6 to 18 years) at a local science museum. Factor analysis was conducted to identify OC trait dimensions. Univariate and multivariate twin modeling was performed to estimate the heritability of OC trait dimensions in a subset of twins (220 pairs).ResultsSix OC dimensions were identified: Cleaning/Contamination, Hoarding, Rumination, Superstition, Counting/Checking, and Symmetry/Ordering. The TOCS total score (74%) and OC trait dimensions were heritable (30-77%). Hoarding was phenotypically distinct but shared genetic effects with other OC dimensions. Most of the genetic effects were shared between dimensions while unique environment accounted for the majority of dimension-specific variance, except for hoarding which had considerable unique genetic factors. A latent trait did not account for the shared variance between dimensions.ConclusionsOC traits and individual OC dimensions were heritable, although the degree of shared and dimension-specific etiological factors varied by dimension. The TOCS is useful for genetic research of OC traits and OC dimensions should be examined individually and together along with total trait scores to characterize OC genetic architecture.
Larger legume plants host a greater diversity of symbiotic nitrogen-fixing bacteria
Authors: Dinnage Russell , Simonsen Anna K. , Cardillo Marcel , Thrall Peter H. , Barrett Luke G. , Prober Suzanne M. 
Published: January 2018

AbstractA major goal in microbial ecology is to understand the factors that structure bacterial communities across space and time. For microbes that have symbiotic relationships with plants, an important factor that may influence their communities is host size or age, yet this has received little attention.Using tree diameter size as a proxy for age, we quantified the diversity of rhizobia that associate with an endemic legume,Acacia acuminata, of variable size across a climate gradient in southwest Australia. We examined the 16S rRNA diversity (V1-V3 hypervariable region) of rhizobia at the taxonomic level and at higher sequence level diversity within taxonomic groups.We identified 3 major taxonomic clades that associated withAcacia acuminata:Bradyrhizobiaceae, Rhizobiaceae, and Burkholderiaceae. Within these groups, we found extensive genetic variability, especially within Bradyrhizobiaceae. Using binomial multivariate statistical models that controlled for other factors that affect plant size and rhizobia community structure (climate and local soil characteristics), we determined that soil sampled at the base of largerAcaciatrees was much more likely to contain a greater number of taxonomic clades and cryptic genetic variants within the Rhizobiaceae clade.Despite strong influences of climate and highly heterogeneous soil conditions on rhizobial diversity, our results show that host tree size is a prominent factor in structuring nitrogen-fixing symbionts diversity across a large landscape. The identification of a positive relationship between plant host size and microbial diversity raise interesting questions about the role of plant host size in driving ecological processes that govern microbial community assembly. Specifically, our results suggest that hosts may modify the habitat of their surrounding soil to enhance growth (niche construction hypothesis) or that symbiotic microbes have large differences in dispersal capability. Our results also suggest that host plants may be analogous to ‘islands’, where larger legume hosts may accumulate diversity over time, through migration opportunities or in situ diversification. From a practical perspective, including plant size as an additional variable may assist sampling and analyses designs of future soil microbial studies.
Limitation of alignment-free tools in total RNA-seq quantification
Authors: Wu Douglas C. , Yao Jun , Ho Kevin S. , Lambowitz Alan M. , Wilke Claus O. 
Published: January 2018

AbstractBackgroundAlignment-free RNA quantification tools have significantly increased the speed of RNA-seq analysis. However, it is unclear whether these state-of-the-art RNA-seq analysis pipelines can quantify small RNAs as accurately as they do with long RNAs in the context of total RNA quantification.ResultWe comprehensively tested and compared four RNA-seq pipelines on the accuracies of gene quantification and fold-change estimation on a novel total RNA benchmarking dataset, in which small non-coding RNAs are highly represented along with other long RNAs. The four RNA-seq pipelines were of two commonly-used alignment-free pipelines and two variants of alignment-based pipelines. We found that all pipelines showed high accuracies for quantifying the expressions of long and highly-abundant genes. However, alignment-free pipelines showed systematically poorer performances in quantifying lowly-abundant and small RNAs.ConclusionWe have shown that alignment-free and traditional alignment-based quantification methods performed similarly for common gene targets, such as protein-coding genes. However, we identified a potential pitfall in analyzing and quantifying lowly-expressed genes and small RNAs with alignment-free pipelines, especially when these small RNAs contain mutations.
A genomic island of Streptomyces coelicolor with the self-contained regulon of an ECF sigma factor
Authors: Kao Camilla M. , Karoonuthaisiri Nitsara , Weaver David , Vroom Jonathan A. , Gai Shuning A. , Ho Mai-Lan , Patel Kedar G. 
Published: January 2018

AbstractStreptomycetes constitute the largest genus of actinobacteria, living predominantly in soil and decaying vegetation. The bacteria are widely known for their filamentous morphologies and their capacity to synthesize antibiotics and other biologically active molecules. More than a decade ago, we and others identified 22 genomic islands thatStreptomyces coelicolorM145 possesses and otherStreptomycesstrains lack. One of these genomic islands, Genomic Island (GI) 6, encodes an extracytoplasmic function (ECF) sigma factor that we were characterizing in separate work. Here we report that artificial induction of the ECF sigma factor, which is encoded by SCO3450, causes the transcription of approximately one-fourth of GI 6, or ~26 mostly contiguous genes, to increase. More than half of the regulon encodes putative enzymes involved in small molecule metabolism. A putative haloacid dehalogenase is present. Genes encoding two putative anti-sigma factors flank SCO3450, the three genes residing within the regulon. Our data suggest that the ECF sigma factor and its regulon are a self-contained transcriptional unit that can be transferred by horizontal gene transfer. To our knowledge, only one other example has been identified of an ECF sigma factor and its contiguous regulon appearing to be transferrable by horizontal gene transfer [18,19]. Because the regulon appears not to be induced by the 44 growth conditions recently examined by Byung-Kwan Cho and colleagues [20], if it confers fitness toS. coelicolor, the regulon likely does so in as-yet unknown situations. Those situations might range from scavenging to detoxification to even communication within microbial communities.IMPORTANCEStreptomycesbacteria grow as hyphae that colonize soil and differentiate into spores when nutrients become scarce. In their terrestrial habitats, the bacteria encounter diverse conditions. Presumably so that the bacteria can cope with those conditions, the chromosomes of streptomycetes are highly dynamic, varying greatly in structure not only between species but also between closely related strains of a single species. The bacteria also have large numbers of extracytoplasmic function (ECF) sigma factors, which undoubtedly help the microorganisms respond to the plethora of challenges coming from the environment. This work illustrates these two threads ofStreptomycesbiology dovetailing: Genetic adaptability through horizontal gene transfer seems to have enabledStreptomyces coelicolorto acquire a self-contained transcriptional unit that consists of an ECF sigma factor and its regulon. The suggested facile movement of the regulon between microbial hosts indicates the value of the metabolism of small molecules possibly mediated by the regulon.
Influence of social media technologies on organizational performance through knowledge and innovation
Authors: Garcia-Morales Victor Jesus , Martín-Rojas Rodrigo , Lardón-López María Esmeralda 
Published: January 2018

PurposeThe purpose of this paper is to show how social media technologies (SMT) make the firm proficient to act on business opportunities and reconfigure business resources by encouraging networks to routinize the firm’s knowledge and innovation competencies.Design/methodology/approachThe paper analyzes data obtained from a sample of 201 technological firms located in Spain. Structural equation modeling with Lisrel is used to test the hypotheses.FindingsThis paper contributes to the literature by reflecting empirically in a structural model how SMT drive technological knowledge competencies to improve organizational performance directly and indirectly by leveraging processes of innovation capability in the firm.Research limitations/implicationsThe study has some limitations, among them transversal analysis of different constructs. The number of relationships analyzed is limited, as is the literature focuses on a digital vision from a social media point of view.Practical implicationsSome implications for managers emerge. SMT both enable an emergent participatory culture through ubiquitous digital devices and social networks and balance constant connectivity afforded by digital devices.Originality/valueDrawing on complexity science, the authors develop a conceptual framework to explain how social media, as emergent IS phenomena, help firms to create business value, leveraging network effects and knowledge flows, and increasing innovative capability.
Market entry strategy for a digital platform provider
Authors: Kim Junic 
Published: January 2018

PurposeHow can a digital platform provider successfully secure users in its early stage to build an ecosystem? The purpose of this paper is to explore this issue through a case study on the deployment of the digital platform service RecordFarm and identifies the reasons behind its successful market access, overcoming the chronic chicken-egg problem in a two-sided market.Design/methodology/approachThe study empirically analyses the core user groups’ diffusion and usage rates by using a susceptible-infectious-recovery model of an epidemic based on a user survey and extensive archival data from the RecordFarm database.FindingsThe study identifies two important early stage characteristics for a business platform to be successful: the core users’ activities on the platform are a critical element for the network’s expansion and usage, and user relationships are more important than user contents on the digital platform.Originality/valueThis study confirms that organic interactions through active behaviours, such as visit frequency, uploading contents, and comment activities, are core elements for a successful digital platform to settle in the market early in the face of the difficulties of a two-sided market.