bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between pro-arrhythmic agents and aortic stenosis in young adults: is it sufficient to clarify the sudden unexpected deaths?
Authors: Radnic Bojana , Radojevic Nemanja , Vucinic Jelena , Duborija-Kovacevic Natasa 
Published: November 2016

AbstractMost young patients with mild-to-moderate aortic stenosis show no symptoms, and sudden death appears only occasionally. We hypothesised that malignant ventricular arrhythmias could be responsible for the high incidence of sudden death in such patients. If multiple factors such as asymptomatic aortic stenosis in association with arrhythmia-provoking agents are involved, could it be sufficient to account for sudden unexpected death? In this study, eight cases of sudden death in young adults, with ages ranging from 22 to 36 years, who had never reported any symptoms that could be related to aortic stenosis, were investigated. Full autopsies were performed, and congenital aortic stenosis in all eight cases was confirmed. DNA testing for channelopathies was negative. Comprehensive toxicological analyses found an electrolyte imbalance, or non-toxic concentrations of amitriptyline, terfenadine, caffeine, and ethanol. Collectively, these results suggest that congenital asymptomatic aortic stenosis without cardiac hypertrophy in young adults is not sufficient to cause sudden death merely on its own; rather, an additional provoking factor is necessary. According to our findings, the provoking factor may be a state of physical or emotional stress, a state of electrolyte imbalance, or even taking a therapeutic dose of a particular drug.
Asenapine for the treatment of adults with an acute exacerbation of schizophrenia: results from a randomized, double-blind, fixed-dose, placebo-controlled trial with olanzapine as an active control
Authors: Landbloom Ronald , Mackle Mary , Wu Xiao , Kelly Linda , Snow-Adami Linda , McIntyre Roger S. , Mathews Maju , Hundt Carla 
Published: November 2016

ObjectiveEvaluate the efficacy and safety of asenapine 2.5 mg twice daily (bid; n=97) or 5 mg bid (n=113) versus placebo (n=101) in adults with acute exacerbation of schizophrenia.MethodsAdults with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) schizophrenia diagnosis were randomized to asenapine 2.5 mg bid, 5 mg bid, placebo, or olanzapine 15 mg once daily. The primary objective was to test superiority of asenapine versus placebo as measured by the change from baseline to day 42 in the Positive and Negative Syndrome Scale (PANSS) total score. The key safety objective was to evaluate weight change in asenapine versus olanzapine at day 42.ResultsThe primary efficacy endpoint was met; the difference in least squares mean change from baseline to day 42 in PANSS total score between asenapine 5 mg bid and placebo was −5.5 points (unadjusted 95% CI: −10.1, −1.0; multiplicity adjusted P=0.0356). Neither asenapine 2.5 mg bid nor olanzapine 15mg were superior to placebo.Both asenapine groups demonstrated significantly less weight gain than olanzapine at day 42. Significantly higher incidences of oral hypoesthesia and dysgeusia (combined) for asenapine 2.5 mg bid (5.2% vs 0.0%; P=0.0217) and 5 mg bid (7.1% vs 0.0%; P=0.0033) were observed versus placebo. There were no significant differences between asenapine and placebo for insomnia, extrapyramidal symptoms, akathisia, dizziness, or combination of somnolence/sedation/hypersomnia.ConclusionThis study supports previous efficacy and safety findings of asenapine; asenapine 5 mg bid is the lowest effective dose in adults with schizophrenia. Asenapine was associated with significantly less weight gain than olanzapine at day 42.
Perinatal, sociodemographic and lifestyle correlates of increased total and visceral fat mass levels in schoolchildren in Greece: the Healthy Growth Study
Authors: Moschonis George , Kaliora Adriana C , Karatzi Kalliopi , Michaletos Aggelos , Lambrinou Christina-Paulina , Karachaliou Alexandra K , Chrousos George P , Lionis Christos , Manios Yannis 
Published: November 2016

AbstractObjectiveTo identify possibly independent associations of perinatal, sociodemographic and lifestyle factors with childhood total and visceral body fat.DesignA representative sample of 2655 schoolchildren (9–13 years) participated in the Healthy Growth Study, a cross-sectional epidemiological study.SettingSeventy-seven primary schools in four large regions in Greece.SubjectsA sample of 1228 children having full data on total and visceral fat mass levels, as well as on anthropometric, dietary, physical activity, physical examination, socio-economic and perinatal indices, was examined.ResultsMaternal (OR=3·03 and 1·77) and paternal obesity (OR=1·62 and 1·78), maternal smoking during pregnancy (OR=1·72 and 1·93) and rapid infant weight gain (OR=1·42 and 1·96) were significantly and positively associated with children’s increased total and visceral fat mass levels, respectively. Children’s television watching for >2 h/d (OR=1·40) and maternal pre-pregnancy obesity (OR=2·46) were associated with children’s increased total and visceral fat mass level, respectively. Furthermore, increased children’s physical activity (OR=0·66 and 0·47) were significantly and negatively associated with children’s total and visceral fat mass levels, respectively. Lastly, both father’s age >46 years (OR=0·57) and higher maternal educational level (OR=0·45) were associated with children’s increased total visceral fat mass level.ConclusionsParental sociodemographic characteristics, perinatal indices and pre-adolescent lifestyle behaviours were associated with children’s abnormal levels of total and visceral fat mass. Any future programme for childhood prevention either from the perinatal age or at late childhood should take these indices into consideration.
Effects of supplementation of a forage-only diet with wheat bran and sugar beet pulp in organic dairy cows
Authors: Ertl Paul , Zebeli Qendrim , Zollitsch Werner , Knaus Wilhelm 
Published: November 2016

AbstractAlthough levels of concentrate supplementation are generally lower in organic as compared with conventional dairy cows, forage-only (FO) diets are not very common in organic dairy cows because of the resulting limited dry matter intake (DMI) and lower milk production. However, from the perspective of net food production, FO diets or forage diets supplemented only with by-products from the food processing industry, offer considerable potential because they do not compete with humans for food. The aim of the present study was therefore to investigate the effects of adding a mixture of wheat bran and dried sugar beet pulp [0.56:0.44 on a dry matter (DM) basis] to a FO diet on DMI, milk production, chewing activity and production efficiency. Seventeen multiparous and three primiparous mid-lactation Holstein cows were randomly assigned to one of two treatments, receiving either a FO mixture with hay and grass silage in equal proportions (FO) or the same forage mixture supplemented with a mixture of wheat bran and dried sugar beet pulp at a rate of 25% of dietary DM (25%BP). The experiment was conducted in a change-over design with two experimental periods of 7 and 6 weeks, respectively. Overall, feeding the 25%BP diet increased DMI and energy-corrected milk (ECM) yield by 1.8 kg d−1 as compared with cows fed FO. Feed conversion efficiency (kg ECM per kg DMI) and energy efficiency (kg ECM per 10 MJ net energy for lactation intake) were higher in FO, but cows fed FO were in a slightly negative energy balance and also tended to have a higher mobilization of body tissues as compared with cows fed 25%BP. In comparison with FO, cows receiving 25%BP showed less chewing activity per kg DMI or per kg neutral detergent fiber ingested. In conclusion, results from this feeding trial showed that adding wheat bran and dried sugar beet pulp to a FO diet increased DMI and milk yield and improved the energy balance when compared with a FO diet, although the magnitude of the milk yield response was lower than expected.
Working Alliance Inventory for Children and Adolescents	(WAI-CA)
Authors: Figueiredo Bárbara , Dias Pedro , Lima Vânia Sousa , Lamela Diogo 
Published: November 2016

Abstract. The purpose of this study was to validate a version of the Working Alliance Inventory (WAI) for children and adolescents (WAI-CA). The sample included 109 children/adolescents aged between 7 and 17 years, outpatients in a Clinical Psychology Unit (Portugal), who completed the WAI-CA between psychotherapy sessions 3 and 35. A subsample of 30 children/adolescents aged between 10 and 14 years filled out both the WAI-CA and the WAI within a one-to-two week’s interval. A subsample of 57 children/adolescents with ages between 7 and 17 years filled out the WAI-CA, and their accompanying parent the WAI. Results show high internal consistency (Cronbach’s alpha ranging from .71 to .89) and good external validity. Significant differences were found in the bond subscale according to age, gender, and diagnosis, with higher values in children compared to adolescents, in girls compared to boys, and in participants with internalizing and externalizing problems compared to participants with school problems. Moderate to strong significant correlations were found between children/adolescents’ WAI-CA and WAI scores and weak correlations between children/adolescents’ WAI-CA scores and parent’s WAI scores. Results suggest that the WAI-CA is a valid measure of working alliance to be used with children and adolescents.
Assessing Personality With Multi-Descriptor Items
Authors: Schult Johannes , Schneider Rebecca , Sparfeldt Jörn R. 
Published: November 2016

Abstract. The need for efficient personality inventories has led to the wide use of short instruments. The corresponding items often contain multiple, potentially conflicting descriptors within one item. In Study 1 ( N = 198 university students), the reliability and validity of the TIPI (Ten-Item Personality Inventory) was compared with the reliability and validity of a modified TIPI based on items that rephrased each two-descriptor item into two single-descriptor items. In Study 2 ( N = 268 university students), we administered the BFI-10 (Big Five Inventory short version) and a similarly modified version of the BFI-10 without two-descriptor items. In both studies, reliability and construct validity values occasionally improved for separated multi-descriptor items. The inventories with multi-descriptor items showed shortcomings in some factors of the TIPI and the BFI-10. However, the other scales worked comparably well in the original and modified inventories. The limitations of short personality inventories with multi-descriptor items are discussed.
Ancient and methane-derived carbon subsidizes contemporary food webs
Authors: DelVecchia Amanda G. , Stanford Jack A. , Xu Xiaomei 
Published: November 2016

AbstractWhile most global productivity is driven by modern photosynthesis, river ecosystems are supplied by locally fixed and imported carbon that spans a range of ages. Alluvial aquifers of gravel-bedded river floodplains present a conundrum: despite no possibility for photosynthesis in groundwater and extreme paucity of labile organic carbon, they support diverse and abundant large-bodied consumers (stoneflies, Insecta: Plecoptera). Here we show that up to a majority of the biomass carbon composition of these top consumers in four floodplain aquifers of Montana and Washington is methane-derived. The methane carbon ranges in age from modern to up to >50,000 years old and is mostly derived from biogenic sources, although a thermogenic contribution could not be excluded. We document one of the most expansive ecosystems to contain site-wide macroinvertebrate biomass comprised of methane-derived carbon and thereby advance contemporary understanding of basal resources supporting riverine productivity.
Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry
Authors: Kiosze-Becker Kristin , Ori Alessandro , Gerovac Milan , Heuer André , Nürenberg-Goloub Elina , Rashid Umar Jan , Becker Thomas , Beckmann Roland , Beck Martin , Tampé Robert 
Published: November 2016

AbstractRibosome recycling orchestrated by the ATP binding cassette (ABC) protein ABCE1 can be considered as the final—or the first—step within the cyclic process of protein synthesis, connecting translation termination and mRNA surveillance with re-initiation. An ATP-dependent tweezer-like motion of the nucleotide-binding domains in ABCE1 transfers mechanical energy to the ribosome and tears the ribosome subunits apart. The post-recycling complex (PRC) then re-initiates mRNA translation. Here, we probed the so far unknown architecture of the 1-MDa PRC (40S/30S·ABCE1) by chemical cross-linking and mass spectrometry (XL-MS). Our study reveals ABCE1 bound to the translational factor-binding (GTPase) site with multiple cross-link contacts of the helix–loop–helix motif to the S24e ribosomal protein. Cross-linking of the FeS cluster domain to the ribosomal protein S12 substantiates an extreme lever-arm movement of the FeS cluster domain during ribosome recycling. We were thus able to reconstitute and structurally analyse a key complex in the translational cycle, resembling the link between translation initiation and ribosome recycling.
Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex
Authors: Reimer Jacob , McGinley Matthew J , Liu Yang , Rodenkirch Charles , Wang Qi , McCormick David A , Tolias Andreas S 
Published: November 2016

AbstractRapid variations in cortical state during wakefulness have a strong influence on neural and behavioural responses and are tightly coupled to changes in pupil size across species. However, the physiological processes linking cortical state and pupil variations are largely unknown. Here we demonstrate that these rapid variations, during both quiet waking and locomotion, are highly correlated with fluctuations in the activity of corticopetal noradrenergic and cholinergic projections. Rapid dilations of the pupil are tightly associated with phasic activity in noradrenergic axons, whereas longer-lasting dilations of the pupil, such as during locomotion, are accompanied by sustained activity in cholinergic axons. Thus, the pupil can be used to sensitively track the activity in multiple neuromodulatory transmitter systems as they control the state of the waking brain.
Genome sequence and analysis of the Japanese morning glory Ipomoea nil
Authors: Hoshino Atsushi , Jayakumar Vasanthan , Nitasaka Eiji , Toyoda Atsushi , Noguchi Hideki , Itoh Takehiko , Shin-I Tadasu , Minakuchi Yohei , Koda Yuki , Nagano Atsushi J. , Yasugi Masaki , Honjo Mie N. , Kudoh Hiroshi , Seki Motoaki , Kamiya Asako , Shiraki Toshiyuki , Carninci Piero , Asamizu Erika , Nishide Hiroyo , Tanaka Sachiko , Park Kyeung-Il , Morita Yasumasa , Yokoyama Kohei , Uchiyama Ikuo , Tanaka Yoshikazu , Tabata Satoshi , Shinozaki Kazuo , Hayashizaki Yoshihide , Kohara Yuji , Suzuki Yutaka , Sugano Sumio , Fujiyama Asao , Iida Shigeru , Sakakibara Yasubumi 
Published: November 2016

AbstractIpomoeais the largest genus in the family Convolvulaceae.Ipomoea nil(Japanese morning glory) has been utilized as a model plant to study the genetic basis of floricultural traits, with over 1,500 mutant lines. In the present study, we have utilized second- and third-generation-sequencing platforms, and have reported a draft genome ofI. nilwith a scaffold N50 of 2.88 Mb (contig N50 of 1.87 Mb), covering 98% of the 750 Mb genome. Scaffolds covering 91.42% of the assembly are anchored to 15 pseudo-chromosomes. The draft genome has enabled the identification and cataloguing of theTpn1family transposons, known as the major mutagen ofI. nil, and analysing the dwarf gene,CONTRACTED, located on the genetic map published in 1956. Comparative genomics has suggested that a whole genome duplication in Convolvulaceae, distinct from the recent Solanaceae event, has occurred after the divergence of the two sister families.
Magnetic slippery extreme icephobic surfaces
Authors: Irajizad Peyman , Hasnain Munib , Farokhnia Nazanin , Sajadi Seyed Mohammad , Ghasemi Hadi 
Published: November 2016

AbstractAnti-icing surfaces have a critical footprint on daily lives of humans ranging from transportation systems and infrastructure to energy systems, but creation of these surfaces for low temperatures remains elusive. Non-wetting surfaces and liquid-infused surfaces have inspired routes for the development of icephobic surfaces. However, high freezing temperature, high ice adhesion strength, and high cost have restricted their practical applications. Here we report new magnetic slippery surfaces outperforming state-of-the-art icephobic surfaces with a ice formation temperature of −34 °C, 2–3 orders of magnitude higher delay time in ice formation, extremely low ice adhesion strength (≈2 Pa) and stability in shear flows up to Reynolds number of 105. In these surfaces, we exploit the magnetic volumetric force to exclude the role of solid–liquid interface in ice formation. We show that these inexpensive surfaces are universal and can be applied to all types of solids (no required micro/nano structuring) with no compromise to their unprecedented properties.
Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity
Authors: Yang Yang , Liu Fan , Franc Vojtech , Halim Liem Andhyk , Schellekens Huub , Heck Albert J. R. 
Published: November 2016

AbstractMany biopharmaceutical products exhibit extensive structural micro-heterogeneity due to an array of co-occurring post-translational modifications. These modifications often effect the functionality of the product and therefore need to be characterized in detail. Here, we present an integrative approach, combining two advanced mass spectrometry-based methods, high-resolution native mass spectrometry and middle-down proteomics, to analyse this micro-heterogeneity. Taking human erythropoietin and the human plasma properdin as model systems, we demonstrate that this strategy bridges the gap between peptide- and protein-based mass spectrometry platforms, providing the most complete profiling of glycoproteins. Integration of the two methods enabled the discovery of three undescribed C-glycosylation sites on properdin, and revealed in addition unexpected heterogeneity in occupancies of C-mannosylation. Furthermore, using various sources of erythropoietin we define and demonstrate the usage of a biosimilarity score to quantitatively assess structural similarity, which would also be beneficial for profiling other therapeutic proteins and even plasma protein biomarkers.
Combining social cognitive treatment, cognitive remediation, and functional skills training in schizophrenia: a randomized controlled trial
Authors: Peña Javier , Ibarretxe-Bilbao Naroa , Sánchez Pedro , Iriarte Maria B , Elizagarate Edorta , Garay Maria A , Gutiérrez Miguel , Iribarren Aránzazu , Ojeda Natalia 
Published: November 2016

AbstractThis study examined the efficacy of an integrative cognitive remediation program (REHACOP) in improving cognition and functional outcome in patients with schizophrenia. The program combines cognitive remediation, social cognitive intervention, and functional skills training. Few studies have attempted this approach. One hundred and eleven patients diagnosed with schizophrenia were randomly assigned to either the cognitive remediation group (REHACOP) or an active control group (occupational activities) for 4 months (three sessions per week, 90 min). Primary outcomes were change on general neurocognitive performance and social cognition, including theory of mind (ToM), emotion perception (EP), attributional style, and social perception (SP). Secondary outcomes included changes on clinical symptoms (Positive and Negative Syndrome Scale) and functional outcome (UCSD Performance-Based Skills Assessment and the Global Assessment of Functioning). The trial was registered with clinicaltrials.gov (NCT02796417). No baseline group differences were found. Significant differences were found in the mean change between the REHACOP group and control group in neurocognition (

η

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0
.
138

), SP (

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0.082

), ToM (

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0
.
148

), EP (

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2

=
0.071

), negative symptoms (

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2

=
0.082

), emotional distress (

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0
.
136

), Global Assessment of Functioning (

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=
0.081

), and UCSD Performance-Based Skills Assessment (

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0
.
154

). The combination of cognitive remediation, social cognitive intervention, and functional skills training demonstrated statistically significant and clinically meaningful changes in neurocognition, social cognition, negative, and functional disability.
Gene-gene Interaction Analyses for Atrial Fibrillation
Authors: Lin Honghuang , Mueller-Nurasyid Martina , Smith Albert V. , Arking Dan E. , Barnard John , Bartz Traci M. , Lunetta Kathryn L. , Lohman Kurt , Kleber Marcus E. , Lubitz Steven A. , Geelhoed Bastiaan , Trompet Stella , Niemeijer Maartje N. , Kacprowski Tim , Chasman Daniel I. , Klarin Derek , Sinner Moritz F. , Waldenberger Melanie , Meitinger Thomas , Harris Tamara B. , Launer Lenore J. , Soliman Elsayed Z. , Chen Lin Y. , Smith Jonathan D. , Van Wagoner David R. , Rotter Jerome I. , Psaty Bruce M. , Xie Zhijun , Hendricks Audrey E. , Ding Jingzhong , Delgado Graciela E. , Verweij Niek , van der Harst Pim , Macfarlane Peter W. , Ford Ian , Hofman Albert , Uitterlinden André , Heeringa Jan , Franco Oscar H. , Kors Jan A. , Weiss Stefan , Völzke Henry , Rose Lynda M. , Natarajan Pradeep , Kathiresan Sekar , Kääb Stefan , Gudnason Vilmundur , Alonso Alvaro , Chung Mina K. , Heckbert Susan R. , Benjamin Emelia J. , Liu Yongmei , März Winfried , Rienstra Michiel , Jukema J. Wouter , Stricker Bruno H. , Dörr Marcus , Albert Christine M. , Ellinor Patrick T. 
Published: November 2016

AbstractAtrial fibrillation (AF) is a heritable disease that affects more than thirty million individuals worldwide. Extensive efforts have been devoted to the study of genetic determinants of AF. The objective of our study is to examine the effect of gene-gene interaction on AF susceptibility. We performed a large-scale association analysis of gene-gene interactions with AF in 8,173 AF cases, and 65,237 AF-free referents collected from 15 studies for discovery. We examined putative interactions between genome-wide SNPs and 17 known AF-related SNPs. The top interactions were then tested for association in an independent cohort for replication, which included more than 2,363 AF cases and 114,746 AF-free referents. One interaction, between rs7164883 at the HCN4 locus and rs4980345 at the SLC28A1 locus, was found to be significantly associated with AF in the discovery cohorts (interaction OR = 1.44, 95% CI: 1.27–1.65, P = 4.3 × 10–8). Eight additional gene-gene interactions were also marginally significant (P < 5 × 10–7). However, none of the top interactions were replicated. In summary, we did not find significant interactions that were associated with AF susceptibility. Future increases in sample size and denser genotyping might facilitate the identification of gene-gene interactions associated with AF.