bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatal paraquat poisoning: a case report and literature review on rapid deterioration and therapeutic challenges
Authors: Barma Aachal , Poudel Aashis , Rawal Gunjana , Karn Mitesh , Kc Unika , Ojha Liladhar , Bajgai Dinesh , Mandal Manisha 
Published: February 2025

Introduction and importance:
Paraquat (PQ) poisoning is a life-threatening condition with a high-mortality rate. As it lacks a specific antidote, treatment is mainly supportive, focusing on reducing oxidative damage and organ dysfunction. Despite aggressive intervention, the condition can rapidly progress to multiorgan failure. This report presents a fatal case of PQ poisoning, highlighting its clinical course and management challenges.

Case presentation:
A 45-year-old female ingested 10 mL of 20% PQ, presenting with vomiting, dizziness, and generalized body aches. At presentation, she was alert, with stable vital signs and no significant findings. Immediate treatment, including gastric lavage, activated charcoal, corticosteroids, antioxidants, and monitoring of renal and hepatic function, was initiated. On Day 2, her condition deteriorated with jaundice, respiratory distress, and PQ-induced tongue ulcers. Lab results showed worsening renal and hepatic dysfunction. She received cyclophosphamide, N-acetylcysteine, and heparin-free hemodialysis, but her condition continued to decline, leading to multiorgan failure. She succumbed to her condition on the fourth day.

Clinical discussion:
PQ toxicity causes oxidative stress, resulting in rapid progression to multiorgan failure. Early decontamination and supportive care are key, but no curative treatment exists. The rapid progression and limited effectiveness of current therapies make management difficult.

Conclusion:
PQ poisoning remains a critical medical emergency with a high-mortality rate. Timely recognition, aggressive supportive care, and further research into novel detoxification and therapeutic strategies are essential to improving survival outcomes. Additionally, public health measures, including stricter regulations and increased awareness regarding PQ’s toxicity, are crucial in preventing future cases.
Comparative Study of Inflammatory and Fibrotic Reactions Induced by Silicone Implants with Different Hardness
Authors: Lee Da Woon , Jang Si-Hyong , Kim Hyun , Kim Taek Kyun , Byeon Je Yeon , Choi Hwan Jun 
Published: February 2025

Background:
Silicone nasal implants have been widely used in rhinoplasty. However, research on the correlation between implant hardness and the development of fibrosis and inflammation is lacking. This study investigated how the hardness of silicone implants influences fibrosis and inflammation through an experimental investigation.

Methods:
Three types of nasal silicone implants with varying hardness levels were implanted bilaterally on the backs of 15 Wistar rats. Ten weeks post-implantation, clinical aspects, such as differences in immune reactions and formation of peri-implant capsules were analyzed. The intra-tissue response of the host was assessed by qRT-PCR using 11 markers. Specific markers were investigated by immunohistochemical (IHC) staining. Pathological grading was performed to investigate inflammation and fibrosis in the peri-implant tissues. Quantification and statistical analysis of these parameters were conducted to derive scores for intergroup comparisons.

Results:
Histological analysis of the 45 capsules obtained revealed lower levels of fibrosis and acute inflammation in the group with lower hardness. This result was confirmed by IHC staining. Hematoxylin and eosin staining showed that the capsule thickness was less in the low-hardness group. Additionally, inflammation resolved quickly in the low-hardness group, and mature fibrotic tissue was observed.

Conclusions:
When silicone implants are stably positioned within the body, less-rigid implants exhibit lower inflammatory or fibrotic responses. This is directly related to the adverse effects associated with capsule formation. These findings contribute to our understanding of the behavior of heterotopic materials in the nasal dorsum and their effects on the skin and soft tissue envelope.
Stress drives plasticity in leaf maturation transcriptional dynamics
Authors: Swift Joseph , Wu Xuelin , Xu Jiaying , Jain Tanvi , Illouz-Eliaz Natanella , Nery Joseph R. , Chory Joanne , Ecker Joseph R. 
Published: February 2025

AbstractLeaf development is dynamic, adapting to environmental stress to optimize resource use. For example, in response to drought,Arabidopsisrestricts leaf growth to enhance water use efficiency. While this plastic response is well described at the physiological level, the underlying transcriptional changes that facilitate adjustments in leaf development in response to stress remain poorly described. By constructing a ∼1 million single-nuclei transcriptome atlas, we demonstrate that drought stress limits leaf growth by advancing transcriptional responses related to maturation and aging. Notably, we find that these transcriptional changes scale with environmental stress, and help explain how shoot size can decline proportionally with stress intensity. Leveraging these insights, we increased leaf growth under stress by cell-type targeted upregulation ofFERRIC REDUCTION OXIDASE 6in the mesophyll.
Early and late RNA eQTL are driven by different genetic mechanisms
Authors: Sakaue Saori ,   Accelerating Medicines Partnership®: RA/SLE Network, Raychaudhuri Soumya 
Published: February 2025

AbstractUnderstanding the genetic regulation of RNA abundance is essential to defining disease mechanisms. However, conventional expression quantitative loci (eQTL) studies quantify RNA molecules across the transcript lifecycle. While most eQTL likely affect transcription by altering promoter or enhancer function within the nucleus, it is also possible that they modulate any processes after transcription, including chemical modifications and RNA stability in the cytosol. To elucidate distinct eQTL mechanisms of early versus late RNA, we compared eQTL from mature cellular RNA and nascent nuclear RNA in the brain and the kidney. Across tissues, we identified different causal variants for cellular and nuclear eQTL for the sameeGene. Cellular eQTL were enriched in transcribed regions (P=3.3×10-126), suggesting the importance of post-transcriptional regulation. Conversely, nuclear eQTL were enriched in distal regulatory elements (P=7.0×10-32), highlighting the role of DNA transcriptional regulation. For example, we identified stop-gain eQTL variants likely acting through nonsense-mediated decay in cellular eQTL that had no effect in nuclear eQTL. Cellular eQTL were enriched for loci with multiple causal variants in linkage disequilibrium within the transcribed regions, where they may in concert affect RNA stability. We also identified examples of nuclear eQTL variants within enhancers that had no effect in cellular eQTL. We show that such eQTL (e.g.,TUBGCP4) sometimes uniquely colocalize with disease alleles (schizophrenia). This study reveals key differences in the genetic mechanisms of cellular and nuclear eQTL.
Sericanthe etugeiandS. onanae(Coffeeae Rubiaceae) new cloud forest tree species Endangered in Southwest Cameroon & Bioko (Equatorial Guinea)
Authors: Cheek Martin , Onana Jean Michel , Sonké Bonaventure 
Published: February 2025

SummaryTwo new species of cloudforest tree are described and illustrated from the Cross-Sanaga Interval within the Lower Guinea Domain.Sericanthe etugeiCheek from South West and Littoral Regions of Cameroon is species from the Cameroon Highlands, andSericanthe onanaeCheek from South West Region, Cameroon, and Bioko (Equatorial Guinea).Sericanthe etugeiis similar toSericanthe leonardii(N. Hallé) Robbr. of DRC (Kivu) and Rwanda, differing in the stipular awn 0.25 mm long (vs 1 – 4 mm), the adaxial leaf midrib and secondary nerves glabrous (vs hairy), the tertiary nerves conspicuously scalariform with the naked eye (vs not visible). The species is also similar toSericanthe testuivar.testui,differing in being a tree (vs liana), with stems not decorticating (vs decorticating), the calyx truncate in bud (vs closed) and in the pubescent ovary (vs glabrous).Sericanthe onanaeis similar toS. mpassaSonké & Robbr. of lowland forest in Gabon, differing from that species in that the leaves have an acumen (0.5 – )0.7 – 0.8(– 1.2) cm long vs 0.3 – 0.5 cm, secondary nerves are 7 – 10 (– 12) on each side of the midrib (vs 4 – 6 inS. mpassa), and that the stipules are 5 – 6.5( – 7) × 3 – 5(– 6) mm ( vs 2.5 mm long) and truncate (vs overtopped by an awn c. 1 mm long). It is also similar toS. jacfelicis(N. Halle) Robbr., differing in that the leaves are smaller (<15 cm long vs 16 – 20 cm long), the abaxial surface of the leaf blade has 7 – 10( –12) lateral nerves on each side of the midrib (vs 5 –7) and has a glossy surface and papery texture (vs matt, coriaceous), the petioles are hairy (vs glabrous), the stipules are 5 – 6.5( – 7) mm long, truncate, lacking an awn or arista, (vs 3 –4 mm long, with an arista 0.5 – 1 mm long). These two new species are both provisionally assessed as Endangered EN B2ab(iii) with the 2012 IUCN standard.The new species are briefly discussed in the context of other newly discovered submontane species from the Cross-Sanaga Interval. We speculate that the seeds of these species may be primate-dispersed.
Super Quantum Neuroelectromagnetic Dynamics of Action and Percept Potentials
Authors: Kanjua Jolly 
Published: February 2025

ABSTRACTThe spatiotemporal selectivity of neurons to sensory stimuli that underlie the center and surround receptive fields represents the anticommutative and, thus, symmetry that defines sensorimotor transformation. However, owing to the nonabelian nature of the irresponsiveness of neurons to sensory stimuli characterized by inexcitations, symmetry and, thus, transformation does not become apparent. Hence, a neuroscientific model that describes the precise mechanism of the nonabelian gauge group in the brain is unknown. Using quantum field theory, we show visuomotor transformation of natural images in which the superposition of opposite parallel cortical columns creates visual fields and annihilates motor fields. The creation and annihilation operators, magnetic and electric charged particles, are opposed inertia systems that act on each other by raising and lowering each other’s particles, leading to momentum–energy trade-offs, in our case, retinotopic gain and retinomotion loss, and vice versa. The magnetic charged particlesK−,Cl+,Na−, intrinsic to a magnetic neuron, nabla, are predicted to exist opposite parallel to the electrically charged particlesNa+,Cl−,K+of the electrical pyramidal neuron in the neocortex. The implication is that the physical neocortex or electric brain is in concert with a nonphysical complex neocortex or magnetic brain that is hardly detectable but much alive and proactive.
A large-scale genome-wide association meta-analysis for nevus count provides direct insights into the genetics of melanoma
Authors: Jayasinghe G J M S R , Zhu Gu , Pandeya Nirmala , Olsen Catherine M , Martin Nicholas G , Lind Penelope A , Medland Sarah E , Gordon Scott D , Torres Santiago D , Lingham Gareth , Lee Samantha S Y , Nijsten Tamar , Kayser Manfred , Pardo Luba M. , Montgomery Grant W , Hayward Nicholas K , Palmer Jane M , Hunter David J , Han Jiali , Hewitt Alex W , Falchi Mario , Bishop D Timothy , Brown Kevin M , Bataille Veronique , Mackey David A , Iles Mark M , Whiteman David C , Duffy David L , MacGregor Stuart , Law Matthew H 
Published: February 2025

AbstractA greater understanding of the biology of nevi will provide insights into the etiology of melanoma. Our large-scale meta-analysis of 14 nevus genome-wide association study (GWAS) included 85,967 individuals of European ancestry. We identified 29 nevus-associated loci (p < 5×10−8), of which 24 were not previously reported in a GWAS conducted for nevus count alone. We further identified 255 candidate genes for nevus loci, includingSIKE1which is involved in immune response regulation. This is of interest because immune response regulation influences the formation of nevi and melanoma susceptibility. Gene-set enrichment analyses prioritised immune response-related pathways and cancers that do not have a pigmentation component (e.g. breast, prostate, and glioma). This suggests that the biology underlying nevus count captures risk pathways beyond pigmentation that are relevant to melanoma. A nevus polygenic risk score explains 5% of the variance in nevus count, indicating its potential to enhance melanoma risk prediction.
Indonesian Version Of The Perceived Stress Scale- 10 (IPSS): A Psychometric Properties Of The Indonesian PSS-10 in Adolescents With Obesity
Authors: erlena Erlena Erlena , Nurjannah Intansari Nurjannah , Achadiono Deddy Nurwachid , Wibawa Tri , Prihastari Lisa 
Published: February 2025

Introduction: Stress significantly impacts adolescent obesity, which may impact both physical and mental health outcomes. One popular tool for measuring perceived stress is the Perceived Stress Scale-10 (PSS-10). The purpose of this study is to evaluate the validity and reliability of the Indonesian version of the PSS-10 (IPSS) in this demographic.Methods: Participants of 297 adolescents with and without obesity diagnoses. The scale was translated into Indonesian using the translation-back translation technique. For convergent validity, participants filled out the Indonesian PSS-10 and associated psychological tests. The factor structure of the scale was assessed using confirmatory factor analysis (CFA). Cronbach's alpha was used to determine internal consistency, and a group of individuals was evaluated for test-retest reliability over two weeks. Results: The Indonesian conflict of interest nothing declared PSS-10 demonstrated good internal consistency (Cronbach's alpha = 0.862) and CFA supported the two-factor model had acceptable fit indices ( CFI-0.950, RMR- 0.085, RMSE= 0.072) consistent with the original scale, indicating satisfactory construct validity Convergent validity was confirmed through significant correlations with related psychological constructs. Discussion: According to the results, the PSS-10 in Indonesia is a viable and dependable instrument for assessing felt stress in obese teenagers. The tool can be used to understand better the factors associated with stress in this group in both clinical and research settings. Future studies should examine the predictive validity of the scale and how well it applies to other teen demographics
Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis
Authors: Redmond Catherine J. , Steiner Sarah N. , Cohen Erez , Johnson Craig N. , Özlü Nurhan , Coulombe Pierre A. 
Published: February 2025

SUMMARYThe type I intermediate filament proteins keratin 14 (K14) and keratin 15 (K15) are common to all complex epithelia. K14 is highly expressed by progenitor keratinocytes, in which it provides essential mechanical integrity and gates keratinocyte entry into differentiation by sequestering YAP1, a transcriptional effector of Hippo signaling, to the cytoplasm. K15 has long been used as a marker of hair bulge stem cells though its specific role in skin epithelia is unknown. Here we show that the lack of two biochemical determinants, a cysteine residue within the stutter motif of the central rod domain and a 14-3-3 binding site in the N-terminal head domain, renders K15 unable to effectively sequester YAP1 in the cytoplasm. We combine insight obtained from cell culture and transgenic mouse models with computational analyses of transcriptomics data and propose a model in which the K15:K14 ratio promotes a progenitor state and antagonizes differentiation in keratinocytes of the epidermis.
Does financial experience of women owners of micro businesses promote microfinance lending and their continued existence in rural Uganda?
Authors: Okello Candiya Bongomin George , Semukono Frederick , Baleke Yiga Lubega Joseph , Yourougou Pierre 
Published: February 2025

PurposeFinancial experience is very important in today’s dynamic world of constant globalization with the upsurge in sophisticated financial products entering the financial markets, especially in developing countries. This is because it helps the illiterate unbanked poor women owners of micro businesses to make wise financial judgments and options guided by psychology and cognition. This paper aims to ascertain how financial experience can promote microfinance lending and the continued existence of women micro businesses in rural Uganda through an intervening role.Design/methodology/approachThe paper employs a structural equation model through SmartPLS software to ascertain how financial experience can promote microfinance lending and the continued existence of women micro businesses in rural Uganda through an intervening role.FindingsThe empirical findings from this study indicated that financial experience, as a significant and positive mediator, improves microfinance lending and the continued existence of women micro businesses in rural Uganda.Research limitations/implicationsOwing to the geographical ambit of the current study and sample source from only one developing country, future studies may collect data from other regions of the world for comparative analysis to give more insights on the role of financial experience in rural financial markets.Practical implicationsThe government of Uganda should promote financial literacy to enhance the financial experience of women owners of micro businesses to help them make better financial judgements in the rural financial markets. This may increase microfinance lending and the continued existence of vibrant women micro businesses in rural areas. As a result, this could lead to the creation of more jobs for the ever-growing younger population in Uganda.Originality/valueThis study is motivated by the lack of understanding and experience about key financial concepts among more than 3.5 billion adults, mostly women. It applies the Experiential Learning Theory grounded in psychology and cognition to show how the financial experience of women who run micro businesses derived from repeated retrieval of knowledge and reflection, can help them to make sound financial judgments to become financially included by rural-based microfinance institutions. Learning-by-doing allows women owners of micro businesses to repetitively take prudent saving, borrowing and investment selections that help them to generate income to meet timely loan repayment to access more microcredit for the continued existence. This is inadequate in the current theory of microfinance lending in rural financial markets.
Customer sustainability perception: a scale development study for food products
Authors: Panda Rajesh , Swar Biranchi Narayan 
Published: February 2025

PurposeWith increasing consumer awareness about sustainability, there is a notable shift towards sustainable consumption. This study investigates branded food products and consumer perceptions of sustainability in India, aiming to understand how consumers perceive sustainability. The research proposes and validates the customer sustainability perception (CSP) scale, which includes four dimensions: marketing communication, experiential dimension, product attributes and social media information.Design/methodology/approachEmploying rigorous data analysis techniques, the study uses exploratory factor analysis (EFA) to uncover latent factors and confirmatory factor analysis (CFA) to validate the structure and reliability of the CSP scale across two samples. These methods ensure the robustness and reliability of the proposed framework.FindingsThe findings validate the CSP scale, revealing that consumer perceptions of sustainability are influenced by marketing communication, product attributes, experiential dimensions and social media information. The empirical validation of the CSP framework offers practical insights for businesses to enhance their sustainability strategies and effectively communicate with environmentally conscious consumers.Practical implicationsBusinesses can leverage these insights to enhance their sustainability strategies and communicate eco-friendly initiatives effectively. This robust foundation supports future studies and practical applications in sustainable marketing.Originality/valueThis research advances theoretical understanding by integrating diverse dimensions of consumer perceptions into a cohesive framework. The CSP scale provides a comprehensive tool for measuring consumer sustainability perceptions and elucidates the interrelationships between various factors influencing consumer behaviour.
Digital markets: formative components, regulation, challenges and insights from the European Union Digital Markets Act
Authors: Ozili Peterson 
Published: February 2025

Purpose
This study aims to examine digital markets, their formative components, regulation and challenges. It also presents a concise definition of “digital markets” and suggests a link between digital markets and digital financial inclusion.

Design/methodology/approach
This study adopts a conceptual discussion of digital markets, their formative components and regulation.

Findings
The study projects digital markets to be a game changer for society. It analyses the regulation of digital markets, particularly the recent European Union Digital Markets Act, and show that regulation focus mostly on large technological companies. The study also shows the benefits of digital market regulation for users of digital markets and the demerits for the large technological companies who own the world’s largest digital transactional platforms in digital markets. The criticisms of regulating large technological companies are also identified.

Originality/value
There has been very little policy or academic discussion or debate about the value of digital markets in the literature. Most debates in the literature focus on the large technological companies that operate in digital markets, but there are no discussions or debates in the literature about the value proposition of digital markets as a standalone concept.