bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of system using beam's eye view images to measure respiratory motion tracking errors in image‐guided robotic radiosurgery system
Authors: Inoue Mitsuhiro , Shiomi Hiroya , Iwata Hiromitsu , Taguchi Junichi , Okawa Kohei , Kikuchi Chie , Inada Kosaku , Iwabuchi Michio , Murai Taro , Koike Izumi , Tatewaki Koshi , Ohta Seiji , Inoue Tomio 
Published: February 2017

The accuracy of the CyberKnife Synchrony Respiratory Tracking System (SRTS) is considered to be patient‐dependent because the SRTS relies on an individual correlation between the internal tumor position (ITP) and the external marker position (EMP), as well as a prediction method to compensate for the delay incurred to adjust the position of the linear accelerator (linac). We aimed to develop a system for obtaining pretreatment statistical measurements of the SRTS tracking error by using beam's eye view (BEV) images, to enable the prediction of the patient‐specific accuracy. The respiratory motion data for the ITP and the EMP were derived from cine MR images obtained from 23 patients. The dynamic motion phantom was used to reproduce both the ITP and EMP motions. The CyberKnife was subsequently operated with the SRTS, with a CCD camera mounted on the head of the linac. BEV images from the CCD camera were recorded during the tracking of a ball target by the linac. The tracking error was measured at 15 Hz using in‐house software. To assess the precision of the position detection using an MR image, the positions of test tubes (determined from MR images) were compared with their actual positions. To assess the precision of the position detection of the ball, ball positions measured from BEV images were compared with values measured using a Vernier caliper. The SRTS accuracy was evaluated by determining the tracking error that could be identified with a probability of more than 95% (Ep95). The detection precision of the tumor position (determined from cine MR images) was . The detection precision of the tracking error when using the BEV images was . These two detection precisions were derived from our measurement system and were not obtained from the SRTS. The median of Ep95 was found to be 1.5 (range, 1.0–3.5) mm. The difference between the minimum and maximum Ep95 was 2.5 mm, indicating that this provides a better means of evaluating patient‐specific SRTS accuracy. A suitable margin, based on the predicted patient‐specific SRTS accuracy, can be added to the clinical target volume.PACS number: 87.53.Ly
Modeling and measurement of the variations of CT number distributions for mobile targets in cone‐beam computed tomographic imaging
Authors: Ali Imad , Alsbou Nesreen , Ahmad Salahuddin 
Published: February 2017

The purpose of this study was to investigate quantitatively by measurement and modeling the variations in CT number distributions of mobile targets in cone‐beam CT (CBCT) imaging. CBCT images were acquired for three targets manufactured from homogenous water‐equivalent gel that was inserted into a commercial mobile thorax phantom. The phantom moved with a controlled cyclic motion in one‐dimension along the superior–inferior direction to simulate patient respiratory motion. Profiles of the CT number distributions of the static and mobile targets were obtained using CBCT images. A mathematical model was developed that predicted the variations in CT number distributions and their dependence on the motion parameters of targets moving in one‐dimension using CBCT imaging. The measured CT number distributions for the mobile targets varied considerably, depending on the motion parameters. The extension of the CT number distribution increased linearly with motion amplitude where maximum target elongation reached twice the motion amplitude. The CT number levels of the mobile targets were smeared over a longer distribution; for example, the CT number level for the 20 mm target dropped by nearly 30% at motion amplitude (A) equal to 20 mm in comparison with the CT number distribution of stationary targets. Frequency of motion played an important role in spatial and level variations of the CT number distributions. For example, the level of the CT number profile for the medium target (20 mm) decreased evenly by nearly 50% at with high motion frequencies. Motion phase did not affect the CT number distributions for prolonged projection acquisition that included several respiratory cycles. The mathematical model of the CT number distributions of mobile targets in CBCT reproduced well the measured CT number distributions and predicted their dependence on the target size and phantom motion parameters such as speed, amplitude, frequency, and phase. The CT number distributions varied considerably with motion in CBCT. A motion model of CT number distribution for mobile targets has been developed in this work that predicted well the variations in the measured CT number profiles and their dependence on motion parameters. The model corrected the CT number distribution retrospective to CT image reconstruction where it used a first‐order linear relationship between the number of projections collected in the imaging window of a mobile voxel to obtain the cumulative CT number. This model provides quantitative characterization of motion artifacts on CT number distributions in CBCT that is useful to determine the validity of CT numbers and the accuracy of localization and volume measurement of tumors in diagnostic imaging and interventional applications, such as radiotherapy.PACS number: 87.57.C‐
Usefulness of direct‐conversion flat‐panel detector system as a quality assurance tool for high‐dose‐rate 192Ir source
Authors: Miyahara Yoshinori , Kitagaki Hajime , Nishimura Tomonori , Itakura Kanae , Takahashi Shinobu , Yokokawa Masaki , Uchida Nobue , Inomata Taisuke 
Published: February 2017

The routine quality assurance (QA) procedure for a high‐dose‐rate (HDR) radioactive source is an important task to provide appropriate brachytherapy. Traditionally, it has been difficult to obtain good quality images using the source due to irradiation from the high‐energy gamma rays. However, a direct‐conversion flat‐panel detector (d‐FPD) has made it possible to confirm the localization and configuration of the source. The purpose of the present study was to evaluate positional and temporal accuracy of the source using a d‐FPD system, and the usefulness of d‐FPD as a QA tool. As a weekly verification of source positional accuracy test, we obtained core imaging by single‐shot radiography for three different positions (1300/1400/1500 mm) of a check ruler. To acquire images for measurement of the source movement distance with varying interval steps (2.5/5.0/10.0 mm) and temporal accuracy, we used the high‐speed image acquisition technique and digital subtraction. For accuracy of the source dwell time, sequential images were obtained using various dwell times ranging from 0.5 to 30.0 sec, and the acquired number of image frames was assessed. Analysis of the data was performed using the measurement analysis function of the d‐FPD system. Although there were slight weekly variations in source positional accuracy, the measured positional errors were less than 1.0 mm. For source temporal accuracy, the temporal errors were less than 1.0%, and the correlation between acquired frames and programmed time showed excellent linearity (). All core images were acquired clearly without image halation, and the data were obtained quantitatively. All data were successfully stored in the picture archiving and communication system (PACS) for time‐series analysis. The d‐FPD is considered useful as the QA tool for the source.PACS number: 87.56.Fc
Quantitative evaluation of 3D dosimetry for stereotactic volumetric‐modulated arc delivery using COMPASS
Authors: Vikraman Subramani , Manigandan Durai , Karrthick Karukkupalayam Palaniappan , Sambasivaselli Raju , Senniandavar Vellaingiri , Ramu Mahendran , Rajesh Thiyagarajan , Lutz Muller , Muthukumaran Manavalan , Karthikeyan Nithyanantham , Tejinder Kataria 
Published: February 2017

The purpose of this study was to evaluate quantitatively the patient‐specific 3D dosimetry tool COMPASS with 2D array MatriXX detector for stereotactic volumetric‐modulated arc delivery. Twenty‐five patients CT images and RT structures from different sites (brain, head & neck, thorax, abdomen, and spine) were taken from CyberKnife Multiplan planning system for this study. All these patients underwent radical stereotactic treatment in CyberKnife. For each patient, linac based volumetric‐modulated arc therapy (VMAT) stereotactic plans were generated in Monaco TPS v3.1 using Elekta Beam Modulator MLC. Dose prescription was in the range of 5–20 Gy per fraction. Target prescription and critical organ constraints were tried to match the delivered treatment plans. Each plan quality was analyzed using conformity index (CI), conformity number (CN), gradient Index (GI), target coverage (TC), and dose to 95% of volume (). Monaco Monte Carlo (MC)‐calculated treatment plan delivery accuracy was quantitatively evaluated with COMPASS‐calculated (CCA) dose and COMPASS indirectly measured (CME) dose based on dose‐volume histogram metrics. In order to ascertain the potential of COMPASS 3D dosimetry for stereotactic plan delivery, 2D fluence verification was performed with MatriXX using MultiCube phantom. Routine quality assurance of absolute point dose verification was performed to check the overall delivery accuracy. Quantitative analyses of dose delivery verification were compared with pass and fail criteria of 3 mm and 3% distance to agreement and dose differences. Gamma passing rate was compared with 2D fluence verification from MatriXX with MultiCube. Comparison of COMPASS reconstructed dose from measured fluence and COMPASS computed dose has shown a very good agreement with TPS calculated dose. Each plan was evaluated based on dose volume parameters for target volumes such as dose at 95% of volume () and average dose. For critical organs dose at 20% of volume (), dose at 50% of volume (), and maximum point doses were evaluated. Comparison was carried out using gamma analysis with passing criteria of 3 mm and 3%. Mean deviation of was observed for dose at 95% of volume () of target volumes, whereas much less difference was noticed for critical organs. However, significant dose difference was noticed in two cases due to the smaller tumor size. Evaluation of this study revealed that the COMPASS 3D dosimetry is efficient and easy to use for patient‐specific QA of VMAT stereotactic delivery. 3D dosimetric QA with COMPASS provides additional degrees of freedom to check the high‐dose modulated stereotactic delivery with very high precision on patient CT images.PACS numbers: 87.55.Qr, 87.56.Fc
A novel greedy heuristic‐based approach to intraoperative planning for permanent prostate brachytherapy
Authors: Liang Bin , Zhou Fugen , Liu Bo , Wang Junjie , Xu Yong 
Published: February 2017

This paper presents a greedy heuristic‐based double iteration and rectification (DIR) approach to intraoperative planning for permanent prostate brachytherapy. The DIR approach adopts a greedy seed selection (GSS) procedure to obtain a preliminary plan. In this process, the potential seeds are evaluated according to their ability to irradiate target while spare organs at risk (OARs), and their impact on dosimetric homogeneity within target volume. A flexible termination condition is developed for the GSS procedure, which guarantees sufficient dose within target volume while avoids overdosing the OARs. The preliminary treatment plan generated by the GSS procedure is further refined by the double iteration (DI) and rectification procedure. The DI procedure removes the needles containing only one seed (single seed) and implements the GSS procedure again to get a temporary plan. The DI procedure terminates until the needles number of the temporary plan does not decrease. This process is guided by constantly removing undesired part rather than imposing extra constrains. Following the DI procedure, the rectification procedure attempts to replace the remaining single seeds with the acceptable ones within the existing needles. The change of dosimetric distribution (DD) after the replacement is evaluated to determine whether to accept or to withdraw the replacement. Experimental results demonstrate that the treatment plans obtained by the DIR approach caters to all clinical considerations. Compared with currently available methods, DIR approach is faster, more reliable, and more suitable for intraoperative treatment planning in the operation room.PACS number: 87
Dosimetric effects of immobilization devices on SABR for lung cancer using VMAT technique
Authors: Park Jong In , Ye Sung‐Joon , Kim Hak Jae , Park Jong Min 
Published: February 2017

The purpose of this study was to investigate the dosimetric effects of immobilization devices on the dose distributions of stereotactic ablative radiotherapy (SABR) for lung cancer using volumetric‐modulated arc therapy (VMAT) technique. A total of 30 patients who underwent SABR for lung cancer were selected retrospectively. Every patient was immobilized using Body Pro‐Lok with a vacuum bag customized for each patient body shape. Structure sets were generated to include the patient body inside the body structure with and without the immobilization device. Dose distributions, with and without the immobilization device, were calculated using identical VMAT plans for each patient. Correlations between the change in dose‐volumetric parameters and the MU fraction of photon beams penetrating through the immobilization device were analyzed with Pearson correlation coefficients (r). The maximum change in , and the minimum, maximum and mean dose to the planning target volume (PTV) due to the immobilization device were 5%, 7%, 4%, 5%, and 5%, respectively. The maximum changes in the maximum dose to the spinal cord, esophagus, heart, and trachea were 1.3 Gy, 0.9 Gy, 1 Gy, and 1.7 Gy, respectively. Strong correlations were observed between the changes in , the minimum, the maximum, and the mean dose to the PTV, the maximum dose to the esophagus and heart, and the MU fractions, showing values of r higher than 0.7. The decrease in dose to the target volume was considerable for lung SABR using VMAT technique, especially when MU fraction was large.PACS number: 87.55.‐x
Application of off‐line image processing for optimization in chest computed radiography using a low cost system
Authors: Muhogora Wilbroad E. , Msaki Peter , Padovani Renato 
Published: February 2017

The objective of this study was to improve the visibility of anatomical details by applying off‐line postimage processing in chest computed radiography (CR). Four spatial domain‐based external image processing techniques were developed by using MATLAB software version 7.0.0.19920 (R14) and image processing tools. The developed techniques were implemented to sample images and their visual appearances confirmed by two consultant radiologists to be clinically adequate. The techniques were then applied to 200 chest clinical images and randomized with other 100 images previously processed online. These 300 images were presented to three experienced radiologists for image quality assessment using standard quality criteria. The mean and ranges of the average scores for three radiologists were characterized for each of the developed technique and imaging system. The Mann‐Whitney U‐test was used to test the difference of details visibility between the images processed using each of the developed techniques and the corresponding images processed using default algorithms. The results show that the visibility of anatomical features improved significantly () with combinations of intensity values adjustment and/or spatial linear filtering techniques for images acquired using . However, there was no improvement for images acquired using (). In conclusion, the use of external image processing for optimization can be effective in chest CR, but should be implemented in consultations with the radiologists.PACS number: , ,
Accelerated tomotherapy delivery with TomoEdge technique
Authors: Katayama Sonja , Haefner Matthias F , Mohr Angela , Schubert Kai , Oetzel Dieter , Debus Juergen , Sterzing Florian 
Published: February 2017

TomoEDGE is an advanced delivery form of tomotherapy which uses a dynamic secondary collimator. This plan comparison study describes the new features, their clinical applicability, and their effect on plan quality and treatment speed. For the first 45 patients worldwide that were scheduled for a treatment with TomoEdge, at least two plans were created: one with the previous “standard”mode with static jaws and 2.5 cm field width (Reg 2.5) and one with TomoEdge technique and 5 cm field width (Edge 5). If, after analysis in terms of beam on time, integral dose, dose conformity, and organ at risk sparing the treating physician decided that the Edge 5 plan was not suitable for clinical treatment, a plan with TomoEdge and 2.5 cm field width was created (Edge 2.5) and used for the treatment. Among the 45 cases, 30 were suitable for Edge 5 treatment, including treatments of the head and neck, rectal cancer, anal cancer, malignancies of the chest, breast cancer, and palliative treatments. In these cases, the use of a 5 cm field width reduced beam on time by more than 30% without compromising plan quality. The 5 cm beam could not be clinically applied to treatments of the pelvic lymph nodes for prostate cancer and to head and neck irradiations with extensive involvement of the skull, as dose to critical organs at risk such as bladder (average dose 28 Gy vs. 29 Gy, Reg 2.5 vs. Edge 5), small bowel (29% vs. 31%, Reg 2.5 vs. Edge 5) and brain (average dose partial brain 19 Gy vs. 21 Gy, Reg 2.5 vs. Edge 5) increased to a clinically relevant, yet not statistically significant, amount. TomoEdge is an advantageous extension of the tomotherapy technique that can speed up treatments and thus increase patient comfort and safety in the majority of clinical settings.PACS numbers: 87.55.de, 87.55ne
Commissioning and quality assurance of Dynamic WaveArc irradiation
Authors: Sato Sayaka , Miyabe Yuki , Takahashi Kunio , Yamada Masahiro , Nakamura Mitsuhiro , Ishihara Yoshitomo , Yokota Kenji , Kaneko Shuji , Mizowaki Takashi , Monzen Hajime , Hiraoka Masahiro 
Published: February 2017

A novel three‐dimensional unicursal irradiation technique “Dynamic WaveArc” (DWA), which employs simultaneous and continuous gantry and O‐ring rotation during dose delivery, has been implemented in Vero4DRT. The purposes of this study were to develop a commissioning and quality assurance procedure for DWA irradiation, and to assess the accuracy of the mechanical motion and dosimetric control of Vero4DRT. To determine the mechanical accuracy and the dose accuracy with DWA irradiation, 21 verification test patterns with various gantry and ring rotational directions and speeds were generated. These patterns were irradiated while recording the irradiation log data. The differences in gantry position, ring position, and accumulated MU (, and , respectively) between the planned and actual values in the log at each time point were evaluated. Furthermore, the doses delivered were measured using an ionization chamber and spherical phantom. The constancy of radiation output during DWA irradiation was examined by comparison with static beam irradiation. The mean absolute error (MAE) of and were within 0.1° and the maximum error was within 0.2°. The MAE of was within 0.7 MU, and maximum error was 2.7 MU. Errors of accumulated MU were observed only around control points, changing gantry, and ring velocity. The gantry rotational range, in which was greater than or equal to 2.0 MU, was not greater than 3.2%. It was confirmed that the extent of the large differences in accumulated MU was negligibly small during the entire irradiation range. The variation of relative output value for DWA irradiation was within 0.2%, and this was equivalent to conventional arc irradiation with a rotating gantry. In conclusion, a verification procedure for DWA irradiation was designed and implemented. The results demonstrated that Vero4DRT has adequate mechanical accuracy and beam output constancy during gantry and ring rotation.PACS number: 87
An evaluation of the stability of image‐quality parameters of Varian on‐board imaging (OBI) and EPID imaging systems
Authors: Stanley Dennis N. , Papanikolaou Nikos , Gutiérrez Alonso N. 
Published: February 2017

Quality assurance (QA) of the image quality for image‐guided localization systems is crucial to ensure accurate visualization and localization of regions of interest within the patient. In this study, the temporal stability of selected image parameters was assessed and evaluated for kV CBCT mode, planar radiographic k V, and MV modes. The motivation of the study was to better characterize the temporal variability in specific image‐quality parameters. The CATPHAN, QckV‐1, and QC‐3 phantoms were used to evaluate the image‐quality parameters of the imaging systems on a Varian Novalis Tx linear accelerator. The planar radiographic images were analyzed in PIPSpro with high‐contrast spatial resolution being recorded. For OBI kV CBCT, high‐quality head full‐fan acquisition and pelvis half‐fan acquisition modes were evaluated for uniformity, noise, spatial resolution, HU constancy, and geometric distortion. Dose and X‐ray energy for the OBI were recorded using the Unfors RaySafe Xi system with the R/F High Detector for kV planar radiographic and the CT detector for kV CBCT. Dose for the MV EPID was recorded using a PTW975 Semiflex ion chamber, PTW UNIDOS electrometer, and CNMC Plastic Water. For each image‐quality parameter, values were normalized to the mean, and the normalized standard deviations were recorded to evaluate the parameter's temporal variability. For planar radiographic modes, the normalized standard deviations of the spatial resolution were 0.015, 0.008, 0.004 lp/mm and 0.006, 0.009, 0.018 lp/mm for the kV and MV, respectively. The normalized standard deviation of dose for kV and MV were 0.010 mGy and 0.005 mGy, respectively. The standard deviations for full‐and half‐fan kV CBCT modes were averaged together. The following normalized standard deviations for each kV CBCT parameter were: 0.075 HU (uniformity), 0.071 HU (noise), 0.006 mm (AP‐geometric distortion), 0.005 mm (LAT‐geometric distortion), 0.058 mm (slice thickness), 0.124 (f50), 0.031 (HU constancy – Lung), 0.063 (HU constancy – Water), 0.020 (HU constancy – Bone), 0.006 mGy (Dose – Center), 0.004 mGy (Dose –Periphery). Using control chart analysis, institutional QA tolerances were reported as warning and action thresholds based on 1σ and 2σ thresholds. A study was performed to characterize the stability of image‐quality parameters recommended by AAPM Task Group‐142 for the Varian OBI and EPID imaging systems. Both imaging systems show consistent imaging and dosimetric properties over the evaluated time frame.PACS number: 87.10.‐e