bluuebunny/crossref_metadata_2025_split huggingface dataset:
Friedericia Chica, a Medicinal Plant from the Amazon Region, is Repellent Against Aedes Aegypti: In Vivo and Molecular Docking Evidence
Authors: Miorando Daniela , Cristina Maccagnan Juliana , Dalla Vecchia Cristian Alex , Vedoy Ferraz Cleidiane , Monteiro Marcelo , Assunta Busato Maria , Antônio Lutinski Junir , Isadora Roman Maria , de Souza Rezende Renan , Vidal Gutiérrez Max , Hage‐Melim Lorane I. S. , Pontes Franco M. M. , Barison Andersson , Nepel Angelita , Veselinova Anzhela , Roman Junior Walter Antônio 
Published: October 2024

AbstractFridericia chica is widely distributed in Brazil, where it is commonly known as crajiru or pariri in several regions. Despite its popular use for treating inflammations and as an insect repellent, there has been limited assessment of its chemical and biological properties, including its bioinsecticide activities. In this study, we conducted phytochemical analyses and investigated the larvicidal and repellent effects of F. chica against the mosquito Aedes aegypti. The F. chica (HEFc) hydroalcoholic extract was partitioned using column chromatography, and subfractions were analyzed using chromatographic and spectroscopic analyses (ESI‐IT‐MSn and NMR). In addition, HEFc was evaluated for its larvicidal and repellent activities. Phytochemical analyses revealed the presence of 17 constituents, including 2,4‐dihydroxybenzoic and p‐coumaric acids, along with umbelliferone, acetovanilone, myricetin‐3‐O‐glucuronide, and cis‐isorhapontigenin, which are reported for the first time in this species. Although no larvicidal effect was observed at the doses tested, the HEFc exhibited promising repellent effects against A. aegypti, which aligns with its ethnopharmacological potential. In addition, molecular docking studies demonstrated that the compounds of HEFc interacted efficiently with insect odorant binding proteins (OBPs), providing repellent effects. Consistent with the chemical profile and in silico studies, preparations of F. chica have considerable repellent potential.
Multipartite Fluorogenic Sensors for Monitoring Tyrosine Phosphatase Activity
Authors: Hansen Daniel T. , Tu Julian , Bouck Alison W. , Mathis Cheryl L. , Barrios Amy M. 
Published: October 2024

AbstractFluorogenic substrates are essential tools for studying the activity of many enzymes including the protein tyrosine phosphatases (PTPs). Here, we have taken the first step toward the development of genetically encodable sensors for PTP activity using fluorescent and fluorogen‐activating proteins. The Fluorescence‐Activating and absorption Shifting Tag (FAST) is a small protein that becomes fluorescent upon binding to a small molecule dye. We demonstrate that FAST protein can be used as a sensor for PTP‐mediated dephosphorylation of phosphorylated dye molecules. Phosphorylated 4‐hydroxybenzylidene rhodanine (pHBR) is not able to bind to the FAST protein and induce fluorescence, but provides a sensitive assay for PTP activity, readily detecting 100 pM concentrations of PTP1B in the presence of FAST with a kcat value of 19±1 s−1 and a KM value of 93±3 μM. In addition, while phosphorylation of the C‐terminal peptide of split GFP does not result in appreciable change in fluorescence of the reconstituted protein, phosphorylation of the C‐terminal peptide of the split FAST protein abrogates fluorescence. Upon PTP‐mediated dephosphorylation of the C‐terminal peptide, the ability of the N‐ and C‐terminal components to form a fluorescent complex with the small molecule dye is restored, leading to fluorescence.
Impact of a dedicated radial lounge on same‐day discharge percutaneous coronary intervention
Authors: Liberman Federico , Botto Fernando , Benzadon Mariano N. , Lamelas Pablo M. , Spaletra Pablo M. , Mascolo Pablo D. , Ordoñez Santiago , Padilla Lucio T. , Pedernera Gustavo O. , Belardi Jorge , Cura Fernando A. 
Published: October 2024

AbstractBackgroundThe same‐day discharge (SDD) program after elective percutaneous coronary intervention (PCI) is a safe strategy that allows for the optimization of hospital resources. However, the lack of adequate infrastructure and a specially targeted care model may limit its implementation. Our center developed an outpatient care model based on an area designed for percutaneous procedures called radial lounge (RL).AimsEvaluate the efficacy and safety of the RL care model: (1) SDD rate, (2) patient experience, (3) major adverse cardiac events (MACEs) (in‐hospital, 30‐day, and 1‐year mortality and intervention), and (4) vascular access complication. Secondary objective: Impact of RL SDD rate on total elective SDD‐PCI volume.MethodsWe conducted a retrospective observational cohort study at a cardiovascular hospital, including consecutive patients undergoing elective PCI between 2015 and 2022 who were admitted to the conventional hospitalization area (CHA) or the RL about the stated objectives. Patient experience was assessed using the Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey.ResultsA total of 5466 elective PCI procedures were included: 2102 in the RL and 3364 in the CHA. The SDD rate was 85.2% in the RL group and 54% in the CHA. After the implementation of RL, a significant increase in the volume of elective SDD‐PCI was observed and patient satisfaction improved significantly (p < 0.005) with CHA. Finally, a greater amount of MACEs were not observed in the RL.ConclusionsThe PCI program in RL proved to be safe and effective. It showed a higher rate of SDD and a significant improvement in patient experience was observed without affecting safety.
A case of LIMA side branch coronary steal syndrome: a role for embolization
Authors: Picci Andrea , Certo Giuseppe , Ceresa Fabrizio , Patanè Francesco 
Published: October 2024

AbstractFailure to close the side branches of the internal mammary artery can result in ischemia due to coronary steal through a patent mammary artery side branch after coronary artery bypass grafting. The authors present the case of a 56‐year‐old man with recurrent angina after 6 month surgical myocardial revascularization underwent coronary angiography that showed patent left branch of the internal mammary artery. After demonstration of inducible ischemia, effective percutaneous treatment was performed using coil embolization, improving blood flow and clinical symptoms.
Jicama (Pachyrhizus spp.), a nonconventional starch: Effects of citric acid and heat−moisture treatment on properties of starch and its application in film
Authors: Kishore Anand , Singh Anupama , Pati Kalidas , Ojha Ankur 
Published: October 2024

AbstractBackground and ObjectivesThis study investigated the effects of citric acid (CA) and heat–moisture treatment (HMT) on the properties of jicama starch (JS). Furthermore, it explores the potential of modified jicama starch for film preparation.FindingsThe amylose content of the JS increases after HMT and decreases for CA‐modified starch. CA and HMT modification lowered the swelling power, solubility, peak viscosity, breakdown viscosity, final viscosity, setback viscosity, and crystallinity percentage compared to the native JS. After modification, there was an increase in the transition and pasting temperature of JS. The strong peak for the control and treated JS was observed at around 1008 cm−1 wavenumber in the Fourier transform infrared spectroscopy. SEM showed the overlapping and clusters of the granules in all the modified JS. Modified JS‐based film significantly affects the water solubility, barrier, and mechanical properties of film. The film's SEM showed that the CA‐ and HMT‐modified films had more homogeneous surfaces than the native JS film.ConclusionsHMT and CA modification significantly impacted JS properties and improved the film properties for further application.Significance and NoveltyThis study's findings will facilitate selecting an appropriate treatment to enhance the properties of JS for applications in food formulation and sustainable packaging.
Manifold‐Fused Porphyrin‐Nanographene Conjugates
Authors: Oleszak Christoph , Ritterhoff Christian L. , Martin Max M. , Meyer Bernd , Jux Norbert 
Published: October 2024

AbstractA library of novel π‐extended porphyrin‐hexabenzocoronene (HBC) architectures is presented. Two distinct synthetic pathways were utilized to obtain either phenyl‐ or HBC‐fused compounds. Absorption experiments reveal the species’ exciting photophysical and optoelectronic properties. Depending on the degree of π‐extension, the number of porphyrins, and their relative position, a decisive change in shape, panchromatic broadening, and red‐shifting of the absorption curves is observed. Theoretical studies give more profound insight into the molecule's electronic structures, showing vast decreases in HOMO‐LUMO energy gaps.
Comparison of Different Organometallics Towards Electrophilic Aromatic 211At‐Astatinations of Highly Reactive Tetrazines
Authors: Poulie Christian B. M. , Müller Marius , Bom Pedersen Nadia , Martin Marcel , Mühlbauer Valerie , Mattiussi Simona , Jensen Holger , Herth Matthias M. , Maria Battisti Umberto 
Published: October 2024

AbstractOrganometallics can be used as precursors for electrophilic 211At‐statinations. In this report, we compared the potential of aryl trimethylsilanes, ‐germanes, or –stannanes to be used as precursors to 211At‐label highly reactive tetrazines. Tetrazines can be used for pretargeted radioligand therapies or be applied as synthons to radiolabel rapidly and orthogonally a broad set of precursors such as peptides, mAbs or nanomedicines. All precursors could successfully be synthesized and radiolabeled. The reactivity of organogermanium reagents ranged between those of respective organotin and organosilicon precursors. Moreover, organogermanium reagents proved promising for accessing more complex and polar tetrazine scaffolds. In contrast to organotin derivatives, the use of protecting groups could be avoided for organogermanium and ‐silicon precursors. The developed 211At‐labeled tetrazines could be labeled in radiochemical conversions of 60–90 %. Organogermanium and ‐silicon precursors were clearly advantaged as additional deprotection steps could avoided. Reported labeling procedures allow astatinations of highly reactive tetrazines to be used for pretargeted approaches or to applied as highly reactive synthons to label the next‐generation of 211At‐labeled radiopharmaceuticals.
Highly Luminescent Aceno[6]helicenones by Intramolecular Radical Cyclization
Authors: Sturm Ludmilla , Banasiewicz Marzena , Deperasinska Irena , Kozankiewicz Boleslaw , Morawski Olaf , Dechambenoit Pierre , Bock Harald , Nagata Yuuya , Salvagnac Ludovic , Séguy Isabelle , Šámal Michal , Jančařík Andrej 
Published: October 2024

AbstractHelicenes and helicenoid structures are promising candidates for future applications exploiting circularly polarized light. Ideal candidates should possess near‐quantitative photoluminescence quantum yield, a high luminescence dissymmetry factor and an adjustable HOMO‐LUMO gap. However, carbo[n]helicenes are poorly luminescent compounds and they absorb light mainly in the ultraviolet region. Here we show that the incorporation of a carbonyl group into helical scaffold significantly improves the fluorescence quantum yield and shifts the absorption to visible region. Although the carbonyl group is commonly considered as detrimental to efficient emission, fluorescence quantum yields up to Φ=0.43 were recorded. A straightforward synthetic approach to a highly luminescent tetraceno[6]helicenone and an aza analogue has been developed. The key step is a radical cyclization which is achieving dehydrative π‐extension. The aza‐analogue was incorporated as an emitter in organic light emitting diodes (OLEDs) and showed good performance.
Protocol: Assessing the impact of interest‐holder engagement on guideline development: A systematic review
Authors: Lytvyn Lyubov , Petkovic Jennifer , Khabsa Joanne , Magwood Olivia , Campbell Pauline , Graham Ian D. , Pottie Kevin , Bidonde Julia , Limburg Heather , Pollock Danielle , Akl Elie A. , Concannon Thomas W. , Tugwell Peter 
Published: October 2024

AbstractThis is the protocol for a Campbell systematic review. The objectives are as follows. The objective of this review is to identify and synthesize empirical research on the impacts of interest‐holder engagement on the guideline development process and content. Our research questions are as follows: (1) What are the empirical examples of impact on the process in health guideline development across any of the 18 steps of the GIN‐McMaster checklist? (2) What are the empirical examples of impact on the content in health guideline development across any of the 18 steps of the GIN‐McMaster checklist?
Phosphorous Doped Graphitic Carbon Nitride (P‐g‐C3N4) as an Electrochemical Platform for the Simultaneous Detection of Xanthine and Caffeine
Authors: Sakthivel Arunkumar , Alwarappan Subbiah 
Published: October 2024

AbstractA one step strategy was employed for the preparation of phosphorous doped g‐C3N4 (P‐g‐C3N4) using melamine phosphate. Herein, the precursor upon thermal condensation at 550 °C resulted in the formation of P‐g‐C3N4 nanosheets. The as‐synthesised P‐g‐C3N4 nanosheets were characterized by UV‐vis, FT‐IR and Raman spectroscopy. Later, surface morphological analysis were carried out using FESEM and HRTEM. Moreover, the crystalline nature and elemental composition analysis were conducted using XRD and XPS. Following this, P‐g‐C3N4 nanosheets modified glassy carbon (GC) electrode was employed for the simultaneous detection of xanthene and caffeine. The modified electrode was found to be linear in the range of 0.1 to 100 μM (for xanthine) and 0.05 to 100 μM (for caffeine). The limit of detection was found to be 10 nM and 14 nM for xanthine and caffeine respectively. Further, the electrode exhibited a highly selective detection towards each of these analyte when they co‐exists.
Effectiveness of fractionated rituximab in preventing tumor lysis syndrome in aggressive B‐cell lymphoma: Insights from real‐life clinical practice
Authors: Mohamad Jasmine , Bouroumeau Antonin , McKee Thomas A. , Mach Nicolas , Samii Kaveh , Chamuleau Martine , Stenner Frank , Tamburini Jerome , Lang Noémie 
Published: October 2024

AbstractBackgroundTumor lysis syndrome (TLS) is a potentially life‐threatening condition resulting from the rapid destruction of malignant cells, leading to electrolyte imbalances and severe complications, such as acute kidney injury, arrhythmias, and seizures. TLS can be managed through hyperhydration, urate‐lowering treatments, and a steroid prophase strategy.AimsThis study aims to explore the impact of fractionated rituximab, an anti‐CD20 antibody, on the occurrence and severity of TLS during the initial cycle in patients with aggressive B‐cell non‐Hodgkin lymphoma (B‐NHL).MethodsData was retrospectively collected from 94 of 186 patients.ResultsAmong the 94 patients included in the analysis, the median age was 70. Histologies were diffuse large B‐cell lymphoma (75%), Burkitt lymphoma (13%) and high‐grade B‐cell lymphoma (8%). The majority were at an advanced stage (93%) with a high IPI score (75%). Most patients received anthracycline‐containing regimens (72%) and prophylactic allopurinol (83%) and/or rasburicase (26%). Steroid prophase was administered to 82% of patients. The study identified one clinical TLS case and six laboratory TLS cases. Significant TLS factors included BL histology, elevated baseline LDH (⟩500 U/l), and rasburicase usage. Infusion reactions were rare (3%). Median progression‐free survival was 2.6 years, and 2‐year overall survival was 33%, irrespective of TLS occurrence.ConclusionIn this real‐life study, clinical TLS occurrence was low (1%). TLS appeared more frequent in BL but did not impact overall survival. Fractionated initial rituximab dosing in addition to preventive strategies is a feasible approach in preventing clinical TLS, warranting further prospective investigation.
The Role of Microbiome and Probiotics in Chemo‐Radiotherapy‐Induced Diarrhea: A Narrative Review of the Current Evidence
Authors: Khorashadizadeh Sanaz , Abbasifar Sara , Yousefi Mohammad , Fayedeh Farzad , Moodi Ghalibaf AmirAli 
Published: October 2024

ABSTRACTBackgroundIn this article, we review the most recent research on probiotics effects on diarrhea in both human and animal models of the condition along with the therapeutic potential of these compounds based on their findings.Recent FindingsNearly 50%–80% of cancer patients experience chemotherapy‐induced diarrhea (CID), serious gastrointestinal toxicity of chemotherapeutic and radiation regimens that leads to prolonged hospitalizations, cardiovascular problems, electrolyte imbalances, disruptions in cancer treatment, poor cancer prognosis, and death. CID is typically categorized as osmotic diarrhea. The depletion of colonic crypts and villi by radiotherapy and chemotherapy agents interferes with the absorptive function of the intestine, thereby decreasing the absorption of chloride and releasing water into the intestinal lumen. Probiotic supplements have been found to be able to reverse the intestinal damage caused by chemo‐radiation therapy by promoting the growth of crypt and villi and reducing inflammatory pathways. In addition, they support the modulation of immunological and angiogenesis responses in the gut as well as the metabolism of certain digestive enzymes by altering the gut microbiota.ConclusionBeyond the benefits of probiotics, additional clinical research is required to clarify the most effective strain combinations and dosages for preventing chemotherapy and radiotherapy diarrhea.
Halogen Substitution Strategy for Exploiting High‐Performance Molecular Ferroelectrics
Authors: Chen Xingguang , Xu Haojie , Li Wenjing , Luo Junhua , Sun Zhihua 
Published: October 2024

AbstractMolecular ferroelectrics are emerging as a robust family of electric‐ordered materials due to their distinct structural flexibility, molecular tunability, and versatility. In recent years, diverse chemical design approaches have significantly contributed to discovering and optimizing ferroelectric performances of molecule‐based ferroelectric systems. Notably, halogen substitution is one of the most effective strategies for inducing symmetry breaking and optimizing the dipole moments and potential energy barriers. In this minireview, we have summarized recent significant advances of halogen substitution strategy in molecule‐based ferroelectrics, including organic‐inorganic hybrids and metal‐free molecular systems. Subsequently, we discuss the underlying mechanism of halogen substitution to improve ferroelectric performances, including the generation of spontaneous polarization, enhancement of Curie temperature, and bandgap engineering. Finally, the future directions in designing and modulating molecular ferroelectrics by halogen substitution strategy are also highlighted.
Impact of genotype × environment interaction and selection history on genomic prediction in maize (Zea mays L.)
Authors: Costa Martin , Holland James B. , de Leon Natalia , Kaeppler Shawn M. 
Published: October 2024

AbstractBreeders made remarkable progress in improving productivity and stability of cultivars. Breeding progress relies on selecting favorable alleles for performance and stability to produce productive varieties across diverse environments. In this study, we analyzed the Genomes to Fields Initiative 2018–2019 genotype by environment interaction (G × E) dataset, focusing on three populations of double haploid (DH) lines derived from crossing inbrexpired Plant Variety Protection (ex‐PVP) inbred line PHW65 with inbred lines PHN11, Mo44, and MoG. PHW65 is an Iodent/Lancaster‐type inbred; PHN11 is an Iodent type ex‐PVP line; Mo44 is a tropical‐derived inbred; and MoG is an agronomically poor line derived from the variety Mastadon. Hybrids were produced by crossing the resulting DHs with Stiff Stalk testers PHT69 and LH195. The study's objective was to determine the donor inbreds' relative value and understand the impact of selection history on genomic prediction. We conducted a two‐stage analysis to compare hybrid performance and G × E variance of the populations. G × E variance for yield was significantly lower in the PHW65 × PHN11 population relative to the PHW65 × MoG population. The reduced G × E variance of the PHN11 population led to increased indirect prediction accuracy (when training and testing data are drawn from the same population but different environments). In cross‐validation, the PHN11 population had the greatest indirect prediction accuracy 45% of the time, followed by the Mo44 population (30%) and the MoG population (25%). Results demonstrate that prediction accuracy was greater in the population with the longest history of selection for favorable alleles (PHN11), contributing to greater yield stability.
Reducing Interfacial Recombination in Inverted Perovskite Solar Cells With Selenophene‐Substituted PCBM: Comparison With Thiophene and Furan Substitution
Authors: Cabrera‐Espinoza Andrea , Sánchez José G. , Li Wenhui , Collavini Silvia , Ibañez‐Etxeberria Maddi , Kosta Ivet , Ramírez‐Como Magaly , Martínez‐Ferrero Eugenia , Palomares Emilio , Delgado Juan Luis 
Published: October 2024

AbstractReducing the interfacial recombination and improving the charge transfer capability of charge transport layers are effective strategies to enhance the efficiency and stability of perovskite solar cells (PSCs). This study evaluates, for the first time, the effects of selenophene substitution in the chemical structure of phenyl‐butyric acid methyl ester (PCBM) on the performance and stability of inverted PSCs. Selenophene substitution was compared to thiophene and furan substitutions, and the reference PCBM without chalcogenophene moiety. Additionally, this study investigates the differences between using the fullerene cages C70 and C60 in the PCBM chemical structure. The photovoltaic results demonstrate that, with an adequate control of the thickness of the electron transport layer (ETL), incorporating the selenophene moiety in the structures of fullerenes enhances the photovoltaic parameters of PSCs. This improvement results from the reduction in trap‐assisted recombination, an increase in electron mobility, and the improved charge extraction processes. The use of C70, as opposed to C60, allows for the preparation of a series of ETLs with comparable thicknesses, although slightly lower efficiencies. This feature facilitates a systematic comparative analysis focused on variations in the electron properties of ETLs, thereby avoiding the inclusion of issues related to thickness and charge recombination processes.