bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of high-fat diet on somatic growth, metabolic parameters and function of peritoneal macrophages of young rats submitted to a maternal low-protein diet
Authors: Alheiros-Lira Maria Cláudia , Jurema-Santos Gabriela Carvalho , da-Silva Helyson Tomaz , da-Silva Amanda Cabral , Moreno Senna Sueli , Ferreira e Silva Wylla Tatiana , Ferraz José Candido , Leandro Carol Góis 
Published: April 2017

AbstractThis study evaluated the effects of a post-weaning high-fat (HF) diet on somatic growth, food consumption, metabolic parameters, phagocytic rate and nitric oxide (NO) production of peritoneal macrophages in young rats submitted to a maternal low-protein (LP) diet. Male Wistar rats (aged 60 d) were divided in two groups (n22/each) according to their maternal diet during gestation and lactation: control (C, dams fed 17 % casein) and LP (dams fed 8 % casein). At weaning, half of the groups were fed HF diet and two more groups were formed (HF and low protein–high fat (LP-HF)). Somatic growth, food and energy intake, fat depots, serum glucose, cholesterol and leptin concentrations were evaluated. Phagocytic rate and NO production were analysed in peritoneal macrophages under stimulation of zymosan and lipopolysaccharide (LPS)+interferonγ(IFN-γ), respectively. The maternal LP diet altered the somatic parameters of growth and development of pups. LP and LP-HF pups showed a higher body weight gain and food intake than C pups. HF and LP-HF pups showed increased retroperitoneal and epididymal fat depots, serum level of TAG and total cholesterol compared with C and LP pups. After LPS+IFN-γstimulation, LP and LP-HF pups showed reduced NO production when compared with their pairs. Increased phagocytic activity and NO production were seen in LP but not LP-HF peritoneal macrophages. However, peritoneal macrophages of LP pups were hyporesponsive to LPS+IFN-γinduced NO release, even after a post-weaning HF diet. Our data demonstrated that there was an immunomodulation related to dietary fatty acids after the maternal LP diet-induced metabolic programming.
Acute otitis media associated bilateral sudden hearing loss: case report and literature review
Authors: Smith A , Gutteridge I , Elliott D , Cronin M 
Published: April 2017

AbstractBackground:Sudden sensorineural hearing loss is a rare otological condition with potential for dire outcomes including permanent hearing loss. Although the majority of cases are deemed idiopathic, bilateral sudden sensorineural hearing loss represents a rare subset typically related to systemic conditions, with higher morbidity and mortality. A controversial association with acute otitis media has been reported, with few bilateral cases published in the literature.Case report:A very rare case of bilateral sudden sensorineural hearing loss associated with acute otitis media is described, with a review of the literature.Conclusion:The limited evidence available suggests that acute otitis media with tinnitus and/or bacterial pathology may have an increased risk of sudden sensorineural hearing loss, which is consistent with the case described. Although there is no sufficiently powered published evidence to provide definitive treatment guidelines, the literature reviewed suggests that early myringotomy and antibiotics may greatly improve treatment outcomes.
Questionable practices despite good intentions: coping with risk and impact from dementia-related behaviours in care homes
Authors: BACKHOUSE TAMARA , PENHALE BRIDGET , GRAY RICHARD , KILLETT ANNE 
Published: April 2017

ABSTRACTCare-home residents with dementia can experience behavioural and psychological symptoms such as aggression, agitation, anxiety, wandering, calling out and sexual disinhibition. Care-home staff have a duty to keep residents safe. However, residents with dementia can pose particular challenges in this area. In this paper, we draw on a study which explored how care-home staff manage dementia-related behaviours. In-depth ethnographic case studies at four separate care homes were conducted in England. These involved interviews with 40 care-home staff and 384 hours of participant observation. Our analysis showed that some residents with dementia experience behaviours which can either create risks for, or negatively impact on, themselves and/or other residents or staff members. It emerged that the consequences of the behaviours, rather than the behaviours themselves, created difficulties for staff. To cope with the risk and impact of behaviours, staff employed multiple strategies such as surveillance, resident placement, restrictions and forced care. Using the data, we explore how actions taken by staff to manage the risk and impact of behaviours in these communal settings relate to residents’ human rights. Our findings have particular relevance for care-home staff who need support and guidance in this area, for service development worldwide and for the global ageing population whose valued human rights may become under threat, if they require long-term care.
Island conservation issues in international conventions and agreements
Authors: DAHL ARTHUR LYON 
Published: April 2017

SUMMARYIn this review, I look at governance beyond the national level and consider how well island conservation issues are addressed in international conventions and agreements, both global and regional. I focus primarily on small island developing states (SIDS) and look at conventions to which they are parties, in which their needs are specifically mentioned and which have actions directly targeted to SIDS. I also discuss the evolution of international soft law in agreements and action plans to respond to island issues, the role of the secretariats that have been set up by international conventions to support SIDS conservation action and the protection and recognition provided to island protected areas listed under international conventions. The review shows that international governance has increasingly responded to island needs for biodiversity conservation, often with the active participation of SIDS themselves. However, the multiplication of international agreements and their requirements has often surpassed the capacity of island countries to implement them, requiring further adaptations in order to address this problem. The regional organizations of SIDS help to provide an interface with global conventions and international organizations. There remain a number of gaps and challenges that still need to be addressed in order to halt the erosion and hopefully encourage the restoration of island biodiversity.
Parental depressive history, parenting styles, and child psychopathology over 6 years: The contribution of each parent's depressive history to the other's parenting styles
Authors: Kopala-Sibley Daniel C. , Jelinek Caitlin , Kessel Ellen M. , Frost Allison , Allmann Anna E. S. , Klein Daniel N. 
Published: April 2017

AbstractThe link between parental depressive history and parenting styles is well established, as is the association of parenting with child psychopathology. However, little research has examined whether a depressive history in one parent predicts the parenting style of the other parent. As well, relatively little research has tested transactional models of the parenting–child psychopathology relationship in the context of parents' depressive histories. In this study, mothers and fathers of 392 children were assessed for a lifetime history of major depression when their children were 3 years old. They then completed measures of permissiveness and authoritarianism and their child's internalizing and externalizing symptoms when children were 3, 6, and 9 years old. The results showed that a depressive history in one parent predicted the other parent's permissiveness. Analyses then showed that child externalizing symptoms at age 3 predicted maternal permissiveness and authoritarianism and paternal permissiveness at age 6. Maternal permissiveness at age 6 predicted child externalizing symptoms at age 9. No relationships in either direction were found between parenting styles and child internalizing symptoms. The results highlight the importance of considering both parents' depressive histories when understanding parenting styles, and support transactional models of parenting styles and child externalizing symptoms.
Transradial approach for collateral embolisation
Authors: Garg Naveen , Sahu Ankit K. , Khanna Roopali 
Published: April 2017

AbstractSignificant aortopulmonary collaterals in cyanotic CHD patients require closure immediately before definitive intracardiac repair. Traditionally, the transfemoral access has been used for this purpose; however in a few cases, selective and stable hooking of collaterals may be extremely difficult. We describe a case in which we used a new approach for collateral embolisation in a difficult situation.
Ecosystem services and land sparing potential of urban and peri-urban agriculture: A review
Authors: Wilhelm Jennifer A. , Smith Richard G. 
Published: April 2017

AbstractAgricultural expansion contributes to the degradation of biodiverse ecosystems and the services these systems provide. Expansion of urban and peri-urban agriculture (UPA), on the other hand, may hold promise to both expand the portfolio of ecosystem services (ES) available in built environments, where ES are typically low and to reduce pressure to convert sensitive non-urban, non-agricultural ecosystems to agriculture. However, few data are available to support these hypotheses. Here we review and summarize the research conducted on UPA from 320 peer-reviewed papers published between 2000 and 2014. Specifically, we explored the availability of data regarding UPA's impact on ES and disservices. We also assessed the literature for evidence that UPA can contribute to land sparing. We find that the growth in UPA research over this time period points to the emerging recognition of the potential role that UPA systems play in food production worldwide. However, few studies (n= 15) place UPA in the context of ES, and no studies in our review explicitly quantify the land sparing potential of UPA. Additionally, while few studies (n= 19) quantify production potential of UPA, data that are necessary to accurately quantify the role these systems can play in land sparing, our rough estimates suggest that agricultural extensification into the world's urban environments via UPA could spare an area approximately twice the size of the US state of Massachusetts. Expanding future UPA research to include quantification of ES and functions would shed light on the ecological tradeoffs associated with agricultural production in the built environment. As food demand increases and urban populations continue to grow, it will be critical to better understand the role urban environments can play in global agricultural production and ecosystem preservation.
Regulatory theory: commercially sustainable markets rely upon satisfying the public interest in obtaining credible goods
Authors: Warren-Jones Amanda 
Published: April 2017

AbstractRegulatory theory is premised on the failure of markets, prompting a focus on regulators and industry from economic perspectives. This article argues that overlooking the public interest in the sustainability of commercial markets risks markets failing completely. This point is exemplified through health care markets – meeting an essential need – and focuses upon innovative medicines as the most desired products in that market. If this seemingly invulnerable market risks failure, there is a pressing need to consider the public interest in sustainable markets within regulatory literature and practice. Innovative medicines are credence goods, meaning that the sustainability of the market fundamentally relies upon the public trusting regulators to vouch for product quality. Yet, quality is being eroded by patent bodies focused on economic benefits from market growth, rather than ensuring innovatory value. Remunerative bodies are not funding medicines relative to market value, and market authorisation bodies are not vouching for robust safety standards or confining market entry to products for ‘unmet medical need’. Arguably, this failure to assure quality heightens the risk of the market failing where it cannot be substituted by the reputation or credibility of providers of goods and/or information such as health care professionals/institutions, patient groups or industry.
Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma
Authors: Chauhan R , Churchill N D , Mulrooney-Cousins P M , Michalak T I 
Published: April 2017

AbstractHepatitis B virus (HBV) and the closely related woodchuck hepatitis virus (WHV) are potent carcinogens that trigger development of primary hepatocellular carcinoma (HCC). The initial sites of hepadnavirus–host genome integration, their diversity and kinetics of formation can be central to virus persistence and the initiation and progression of HCC. To recognize the nature of the very early virus–host interactions, we explored de novo infection of human hepatocyte-like HepaRG cells with authentic HBV and naive woodchucks with WHV. HepaRG were analyzed from several minutes post exposure to HBV onwards, whereas woodchuck liver biopsies at 1 or 3 h and 6 weeks post infection with WHV. Inverse PCR and clonal sequencing of the amplicons were applied to identify virus–host genomic junctions. HBV and WHV DNA and their replication intermediates became detectable in one hour after virus exposure. Concomitantly, HBV DNA integration into various host genes was detected. Notably, junctions of HBV X gene with retrotransposon sequences, such as LINE1 and LINE2, became prominent shortly after infection. In woodchucks, insertion of WHV X and preS sequences into host genome was evident at 1 and 3 h post infection (h.p.i.), confirming that hepadnavirus under natural conditions integrates into hepatocyte DNA soon after invasion. The HBV and WHV X gene enhancer II/core promotor sequence most often formed initial junctions with host DNA. Moreover, multiple virus–virus DNA fusions appeared from 1 h.p.i. onwards in both infected hepatocytes and woodchuck livers. In summary, HBV DNA integrates almost immediately after infection with a variety of host’s sequences, among which tandemly repeating non-coding DNAs are common. This study revealed that HBV can engage mobile genetic elements from the beginning of infection to induce pro-oncogenic perturbations throughout the host genome. Such swift virus insertion was also evident in natural hepadnaviral infection in woodchucks.
Human Electrical Muscular Incapacitation and Effects on QTc Interval
Authors: Gibbons John A. , Mojica Andrew J. , Peele Mark E. 
Published: April 2017

AbstractHuman Electrical Muscular Incapacitation (HEMI) is used to subdue combative individuals. Changes in cardiac electrical activity have been proposed as the cause of death in a small fraction of these individuals. The current study sought to determine whether changes in QTc interval occur after HEMI exposure. Twenty‐four participants had EKG readings before a 5‐second HEMI exposure and within 30 min after exposure. All subject EKGs were read by a data‐blinded cardiac electrophysiologist who calculated a QT corrected (QTc) interval. QTc interval was calculated using Bazett method. QTc prolongation was defined as >430 ms and a threshold of 30 ms for identifying QTc lengthening. Five participants experienced QTc prolongation and six had QTc lengthening. One participant developed QTc prolongation exceeding 500 ms, which carries a risk of developing multifocal ventricular tachycardia. These results suggest that HEMI exposure may cause EKG changes with a risk of ventricular tachycardia.
Does surgery for deep infiltrating bowel endometriosis improve fertility? A systematic review
Authors: Iversen Maja L. , Seyer‐Hansen Mikkel , Forman Axel 
Published: April 2017

AbstractIntroductionReduced fertility is a major concern in women with endometriosis. The influence of surgery of deep infiltrating endometriosis (DIE) affecting the bowel wall on fertility is controversial and the literature on this field is heterogeneous. In this review we addressed whether surgery for bowel DIE improves the spontaneous pregnancy rate, and the results of in vitro fertilization (IVF), and the potential risk of such surgery.Material and methodsWe conducted a literature search including the terms “deep”, “deep infiltrating”, “bowel”, rectovaginal”, “endometriosis”, “fertility”, “infertility” and “IVF” in PubMed.ResultsNo randomized controlled studies were found. Other publications of relevance included four retrospective and three prospective observational studies. Moreover, one retrospective study compared results of IVF treatment with or without previous surgery for bowel DIE. All studies reported detailed data on surgical complications. The poor data quality precluded firm conclusions. The results indicate, however, the possibility that surgery for bowel DIE may improve the spontaneous pregnancy rate, and positive effects on IVF outcome cannot be excluded. Such surgery will be associated with risk of major complications.ConclusionThe lack of proper data precludes conclusions on the potential role for bowel DIE surgery to improve the spontaneous pregnancy rate and results of IVF treatment. Positive effects cannot be excluded, but the definite risk of major complications must be taken into account.
Methodological issues in governance research: An editor's perspective
Authors: Filatotchev Igor , Wright Mike 
Published: April 2017

AbstractManuscript typeReviewResearch Question/IssueWhat can be learnt with regard to methods in corporate governance research from editorial experience in handling corporate governance manuscripts? We draw on our experience as editors and guest editors of various journals in highlighting some of the methodological challenges in corporate governance research. We consider methodological issues relating to both quantitative and qualitative studies. Within these broad approaches, we discuss implications of theorizing, ownership and types of firms, governance and institutional contexts, omission of governance variables, human and social capital of board members, endogeneity/causality issues, executive remuneration, configurations and interactions of governance constructs, other governance mechanisms, and data sources. Discussion of these issues also highlights the need for more theoretical and empirical consideration of contingent factors influencing governance relationships. We identify possible ways forward and future research avenues.Research Findings/InsightsThere is a need for corporate governance studies to devote greater recognition to the heterogeneity of various governance factors such as ownership types and director expertise. Studies have generally paid insufficient attention to the configurations of corporate governance.Theoretical/Academic ImplicationsFuture research needs to address the connections between the methodological recognition of heterogeneity and configurations and the implications for theorizing.Practitioner/Policy ImplicationsFailure to address these methodological issues implies that conclusions drawn from corporate governance research for practice and policy could well be misleading.
Host‐dependent differences in resource use associated with Anilocra spp. parasitism in two coral reef fishes, as revealed by stable carbon and nitrogen isotope analyses
Authors: Welicky Rachel L. , Demopoulos Amanda W. J. , Sikkel Paul C. 
Published: April 2017

AbstractThe role of parasites in trophic ecology is poorly understood in marine ecosystems. Stable isotope analyses (SIA) have been widely used in studies of trophic ecology, but have rarely been applied to study the role of parasites. Considering that some parasites are associated with altered host foraging patterns, SIA can help elucidate whether parasitism influences host trophic interactions. French grunt (Haemulon flavolineatum), an abundant Caribbean coral reef fish, contributes greatly to trophic connectivity. They typically depart the reef at dusk, feed overnight in seagrass beds, and return to the reef at dawn. The large parasitic isopod Anilocra haemuli commonly infects French grunt, and infected fish are less likely to complete their diel migration, and are in poorer condition than uninfected conspecifics. Brown chromis (Chromis multilineata) are diurnally feeding planktivores and infection by Anilocra chromis does not influence host condition. To determine if Anilocra infection influences host diet and foraging locality, we conducted stable carbon and nitrogen isotope analyses on scale, muscle, heart and gill tissues of infected and uninfected French grunt and brown chromis. We determined that all French grunt had δ13C values representative of seagrass habitats, but infected French grunt were significantly enriched in 13C and 15N compared to uninfected conspecifics. This suggests that compared to uninfected conspecifics, infected French grunt forage in seagrass, but on isotopically enriched prey, and/or are in poorer condition, which can elevate δ13C and δ15N values. For brown chromis, infection did not significantly influence any δ13C and δ15N values; hence they all foraged in the same environment and on similar prey. This is the first study to use SIA to examine differences in resource use by Caribbean coral reef fishes associated with parasitism and to evaluate how closely related parasites might have host‐dependent effects on host trophic ecology.
The Allende multicompound chondrule (ACC)—Chondrule formation in a local super‐dense region of the early solar system
Authors: Bischoff Addi , Wurm Gerhard , Chaussidon Marc , Horstmann Marian , Metzler Knut , Weyrauch Mona , Weinauer Julia 
Published: April 2017

AbstractIn Allende, a very complex compound chondrule (Allende compound chondrule; ACC) was found consisting of at least 16 subchondrules (14 siblings and 2 independents). Its overall texture can roughly be described as a barred olivine object (BO). The BO texture is similar in all siblings, but does not exist in the two independents, which appear as relatively compact olivine‐rich units. Because of secondary alteration of pristine Allende components and the ACC in particular, only limited predictions can be made concerning the original compositions of the colliding melt droplets. Based on textural and mineralogical characteristics, the siblings must have been formed on a very short time scale in a dense, local environment. This is also supported by oxygen isotope systematics showing similar compositions for all 16 subchondrules. Furthermore, the ACC subchondrules are isotopically distinct from typical Allende chondrules, indicating formation in or reaction with a more 16O‐poor reservoir. We modeled constraints on the particle density required at the ACC formation location, using textural, mineral‐chemical, and isotopic observations on this multicompound chondrule to define melt droplet collision conditions. In this context, we discuss the possible relationship between the formation of complex chondrules and the formation of macrochondrules and cluster chondrites. While macrochondrules may have formed under similar or related conditions as complex chondrules, cluster chondrites certainly require different formation conditions. Cluster chondrites represent a mixture of viscously deformed, seemingly young chondrules of different chemical and textural types and a population of older chondrules. Concerning the formation of ACC calculations suggest the existence of very local, kilometer‐sized, and super‐dense chondrule‐forming regions with extremely high solid‐to‐gas mass ratios of 1000 or more.