bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of serum chemerin, vaspin and omentin-1 levels in patients with polycystic ovary syndrome
Authors: Guvenc Yesim , Var Ahmet , Goker Asli , Kuscu Naci Kemal 
Published: May 2016

Objective To determine serum chemerin, vaspin and omentin-1 in overweight and normal weight patients with polycystic ovary syndrome (PCOS) and investigate the possible relationship between these adipokines and metabolic syndrome. Methods This cross sectional study enrolled women with PCOS and healthy women. Serum chemerin, vaspin and omentin-1 were assessed by enzyme-linked immunosorbent assay methods. Results Forty patients with PCOS and 30 healthy controls were included in the study. In the PCOS group, 18 women were overweight (body mass index [BMI] = 25.0–29.9 kg/m2) and 22 had normal weight (BMI = 18.5–24.9 kg/m2). Chemerin, total cholesterol, dehydroepiandrosterone sulphate and free androgen index (FAI) were significantly higher; and high-density lipoprotein cholesterol and sex hormone binding globulin were significantly lower in overweight PCOS patients compared with normal weight PCOS patients. A positive correlation was found between chemerin and BMI, triglyceride, insulin, homeostatic model assessment of insulin resistance and FAI in the PCOS group. There was no difference in serum chemerin, vaspin and omentin-1 between PCOS patients and healthy controls. Conclusion Circulating chemerin was increased in overweight compared with normal weight PCOS patients. The most predictive variables for circulating chemerin in PCOS patients were BMI, FAI and age.
Tailoring graft strategy to calcification severity of aorta in off-pump coronary artery bypass grafting
Authors: Nakamura Yoshitsugu , Nakajima Hiroyuki , Morita Kozo , Okada Norihiro , Tabata Mimiko , Koike Hiroyuki , Kambe Masaru , Uwabe Kazuhiko , Asakura Toshihisa , Iguchi Atsushi , Kimura Fumiko , Niinami Hiroshi 
Published: May 2016

Background: The study aimed to assess the influence of the calcification of the ascending aorta on surgical mortality, postoperative stroke, and completeness of coronary revascularization in patients undergoing off-pump coronary artery bypass grafting with graft strategy tailored to its calcification severity. Methods and results: We examined the clinical records of 726 patients who underwent off-pump coronary artery bypass grafting. The age at operation was 71 ± 8 years. Calcification of the ascending aorta was graded as none–mild (less than spotty) in 668 (92.0%), moderate (<1/4 of circumference) in 26 (3.6%), and severe (>1/4) in 32 (4.4%) by preoperative non-contrast computed tomography. There were no significant differences in the number of distal anastomoses per patient among the three groups (3.3 ± 1.1, 2.9 ± 1.0, and 3.0 ± 0.9, respectively; p = 0.85). Graft strategy was tailored for each patient. Proximal anastomosis with partial clamp was used in 43.8%, 7.7%, and 3.1%, respectively (p < 0.001), while anastomotic devices were used in 6.8%, 30.1%, and 28.1%, respectively (p < 0.001). Other patients had aortic no-touch technique. There were four hospital deaths in the none–mild group (0.6%, p = 0.85). Stroke occurred in 1 (0.1%) patient, an aortic no-touch technique patient with none–mild calcification. Complete revascularization was not possible in 1 (0.1%) patient in the severe calcification group. Patency of saphenous vein graft of distal anastomosis was not different among groups. Conclusion: Influence of the calcification of the ascending aorta was minimized by tailoring graft strategy to calcification severity. It can practically abolish postoperative stroke while maintaining coronary revascularization success rates.
Safety and Tolerability of Stribild in the Southeast United States
Authors: Derrick Caroline Boyd , Lu Zhiqiang Kevin , Caulder Celeste Rudisill , Hester Elizabeth Kelly , Wagner Tyler David , Bookstaver Paul Brandon 
Published: May 2016

Purpose: The purpose of this study is to assess postmarketing safety and tolerability of Stribild (elvitegravir [EVG]/cobicistat [COBI]/tenofovir disoproxil fumarate [TDF]/emtricitabine [FTC]). Methods: A retrospective, pharmacoepidemiologic study in 2 outpatient HIV clinics in the Southeast United States was conducted among adults receiving EVG/COBI/TDF/FTC. We evaluated incidence and treatment-related adverse events, including change in serum creatinine (SCr). Results: Patients were primarily treatment experienced (n = 173, 60%), African American (n = 210, 73%), and males (n = 187, 65%). One hundred ninety-five (68%) patients had any increase in SCr, and 65 (23%) had an increase of ≥0.3 mg/dL. Mean SCr change from baseline to peak was 0.2 mg/dL. Being treatment experienced (odds ratio [OR] = 2.21, 95% confidence interval [CI]: 1.12-4.38) was associated with SCr ≥0.3 mg/dL, while body mass index ≥30 kg/m2 (OR = 0.41, 95% CI: 0.18-0.93) was protective. Twenty (7%) patients discontinued therapy, 3 due to acute kidney injury. Conclusion: Our results demonstrate limited adverse events and low discontinuation rates associated with EVG/COBI/TDF/FTC.
Athletic Performance at the National Basketball Association Combine After Anterior Cruciate Ligament Reconstruction
Authors: Mehran Nima , Williams Phillip N. , Keller Robert A. , Khalil Lafi S. , Lombardo Stephen J. , Kharrazi F. Daniel 
Published: May 2016

Background: Anterior cruciate ligament (ACL) injuries are significant injuries in elite-level basketball players. In-game statistical performance after ACL reconstruction has been demonstrated; however, few studies have reviewed functional performance in National Basketball Association (NBA)–caliber athletes after ACL reconstruction. Purpose: To compare NBA Combine performance of athletes after ACL reconstruction with an age-, size-, and position-matched control group of players with no previous reported knee injury requiring surgery. We hypothesized that there is no difference between the 2 groups in functional performance. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 1092 NBA-caliber players who participated in the NBA Combine between 2000 and 2015 were reviewed. Twenty-one athletes were identified as having primary ACL reconstruction prior to participation in the combine. This study group was compared with an age-, size-, and position-matched control group in objective functional performance testing, including the shuttle run test, lane agility test, three-quarter court sprint, vertical jump (no step), and maximum vertical jump (running start). Results: With regard to quickness and agility, both ACL-reconstructed athletes and controls scored an average of 11.5 seconds in the lane agility test and 3.1 seconds in the shuttle run test ( P = .745 and .346, respectively). Speed and acceleration was measured by the three-quarter court sprint, in which both the study group and the control group averaged 3.3 seconds ( P = .516). In the maximum vertical jump, which demonstrates an athlete’s jumping ability with a running start, the ACL reconstruction group had an average height of 33.6 inches while the controls averaged 33.9 inches ( P = .548). In the standing vertical jump, the ACL reconstruction group averaged 28.2 inches while the control group averaged 29.2 inches ( P = .067). Conclusion: In athletes who are able to return to sport and compete at a high level such as the NBA Combine, there is no significant difference in any combine performance test between players who have had primary ACL reconstruction compared with an age-, size-, and position-matched control group. Clinical Relevance: Athletes with previous ACL reconstruction who are able to return to high-level professional basketball have equivalent performance measures with regard to speed, quickness, and jumping ability as those athletes who have not undergone knee surgery.
Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy
Authors: Herling Carmen Diana , Klaumünzer Marion , Rocha Cristiano Krings , Altmüller Janine , Thiele Holger , Bahlo Jasmin , Kluth Sandra , Crispatzu Giuliano , Herling Marco , Schiller Joanna , Engelke Anja , Tausch Eugen , Döhner Hartmut , Fischer Kirsten , Goede Valentin , Nürnberg Peter , Reinhardt Hans Christian , Stilgenbauer Stephan , Hallek Michael , Kreuzer Karl-Anton 
Published: May 2016

Key Points
First prospective, controlled study to identify complex karyotypes as an independent prognostic factor of survival in CLL. First study to show that mutations in KRAS or POT1 impact treatment response and survival after chemoimmunotherapy.
Add-on LABA in a separate inhaler as asthma step-up therapyversusincreased dose of ICS or ICS/LABA combination inhaler
Authors: Price David B. , Colice Gene , Israel Elliot , Roche Nicolas , Postma Dirkje S. , Guilbert Theresa W. , van Aalderen Willem M.C. , Grigg Jonathan , Hillyer Elizabeth V. , Thomas Victoria , Martin Richard J. 
Published: May 2016

Asthma management guidelines recommend adding a long-acting β2-agonist (LABA) or increasing the dose of inhaled corticosteroid (ICS) as step-up therapy for patients with uncontrolled asthma on ICS monotherapy. However, it is uncertain which option works best, which ICS particle size is most effective, and whether LABA should be administered by separate or combination inhalers.This historical, matched cohort study compared asthma-related outcomes for patients (aged 12–80 years) prescribed step-up therapy as a ≥50% extrafine ICS dose increase or add-on LABA,viaeither a separate inhaler or a fine-particle ICS/LABA fixed-dose combination (FDC) inhaler. Risk-domain asthma control was the primary end-point in comparisons of cohorts matched for asthma severity and control during the baseline year.After 1:2 cohort matching, the increased extrafine ICSversusseparate ICS+LABA cohorts included 3232 and 6464 patients, respectively, and the fine-particle ICS/LABA FDCversusseparate ICS+LABA cohorts included 7529 and 15 058 patients, respectively (overall mean age 42 years; 61–62% females). Over one outcome year, adjusted OR (95% CI) for achieving asthma control were 1.25 (1.13–1.38) for increased ICSversusseparate ICS+LABA and 1.06 (1.05–1.09) for ICS/LABA FDCversusseparate ICS+LABA.For patients with asthma, increased dose of extrafine-particle ICS, or add-on LABAviaICS/LABA combination inhaler, is associated with significantly better outcomes than ICS+LABAviaseparate inhalers.
Discovering causal interactions using Bayesian network scoring and information gain
Authors: Zeng Zexian , Jiang Xia , Neapolitan Richard 
Published: May 2016

Abstract
Background
The problem of learning causal influences from data has recently attracted much attention. Standard statistical methods can have difficulty learning discrete causes, which interacting to affect a target, because the assumptions in these methods often do not model discrete causal relationships well. An important task then is to learn such interactions from data. Motivated by the problem of learning epistatic interactions from datasets developed in genome-wide association studies (GWAS), researchers conceived new methods for learning discrete interactions. However, many of these methods do not differentiate a model representing a true interaction from a model representing non-interacting causes with strong individual affects. The recent algorithm MBS-IGain addresses this difficulty by using Bayesian network learning and information gain to discover interactions from high-dimensional datasets. However, MBS-IGain requires marginal effects to detect interactions containing more than two causes. If the dataset is not high-dimensional, we can avoid this shortcoming by doing an exhaustive search.

Results
We develop Exhaustive-IGain, which is like MBS-IGain but does an exhaustive search. We compare the performance of Exhaustive-IGain to MBS-IGain using low-dimensional simulated datasets based on interactions with marginal effects and ones based on interactions without marginal effects. Their performance is similar on the datasets based on marginal effects. However, Exhaustive-IGain compellingly outperforms MBS-IGain on the datasets based on 3 and 4-cause interactions without marginal effects. We apply Exhaustive-IGain to investigate how clinical variables interact to affect breast cancer survival, and obtain results that agree with judgements of a breast cancer oncologist.

Conclusions
We conclude that the combined use of information gain and Bayesian network scoring enables us to discover higher order interactions with no marginal effects if we perform an exhaustive search. We further conclude that Exhaustive-IGain can be effective when applied to real data.
Crowdsourcing the nodulation gene network discovery environment
Authors: Li Yupeng , Jackson Scott A. 
Published: May 2016

Abstract
Background
The Legumes (Fabaceae) are an economically and ecologically important group of plant species with the conspicuous capacity for symbiotic nitrogen fixation in root nodules, specialized plant organs containing symbiotic microbes. With the aim of understanding the underlying molecular mechanisms leading to nodulation, many efforts are underway to identify nodulation-related genes and determine how these genes interact with each other. In order to accurately and efficiently reconstruct nodulation gene network, a crowdsourcing platform, CrowdNodNet, was created.

Results
The platform implements the jQuery and vis.js JavaScript libraries, so that users are able to interactively visualize and edit the gene network, and easily access the information about the network, e.g. gene lists, gene interactions and gene functional annotations. In addition, all the gene information is written on MediaWiki pages, enabling users to edit and contribute to the network curation.

Conclusions
Utilizing the continuously updated, collaboratively written, and community-reviewed Wikipedia model, the platform could, in a short time, become a comprehensive knowledge base of nodulation-related pathways. The platform could also be used for other biological processes, and thus has great potential for integrating and advancing our understanding of the functional genomics and systems biology of any process for any species. The platform is available at http://crowd.bioops.info/, and the source code can be openly accessed at https://github.com/bioops/crowdnodnet under MIT License.
Spain: from massive immigration to vast emigration?
Authors: Izquierdo Mario , Jimeno Juan F. , Lacuesta Aitor 
Published: May 2016

AbstractLarge immigration flows during the 1995–2007 period increased the weight of foreigners living in Spain to 12 % of the total population. The rapid increase in unemployment associated with the Great Recession and the subsequent European debt crisis, substantially changed migration flows, so that, from the beginning of the 2010s, Spain experienced positive net outflows. In this paper, we take on three tasks. First, we show that sensitivity of migration flows to unemployment is similar between Spaniards born in Spain and foreigners that entered in Spain during the last 20 years. Second, we estimate the importance of past network effects of foreigners and the recent network effects of Spaniards in shaping these migration flows. Finally, we will use these estimations to conjecture that the rapid creation of networks of Spaniards abroad might keep their emigration rates growing, thus counterbalancing the effects of outflows due to the recent fall in the unemployment rate.
What’s the point? The role of punctuation in realising information structure in written English
Authors: Moore Nick 
Published: May 2016

AbstractThe main claim of this paper is that punctuation marks, in conjunction with spaces between words, function to provide visual rather than auditory cues for information structure in written English.Information structureis defined here as dividing the flow of discourse into units, each containing a newsworthy element, and in contrast to the Systemic Functional systems ofReferenceandTheme. A model of how these three systems interact is further supported by evidence from the historical development of reading and modern studies of the process of fluent silent reading. Reading silently does not require physical articulation and so written text is constrained by the saccading eye rather than the need to draw breath. The silent reader uses punctuation marks as a guide in a saccade to focus on the end of a clause which provides a non-arbitrary location for New information.
Resource Constructs Simulation in Sociology: Methodology, Theory, Practice
Authors: Красовский  , Krasovskiy Yuriy 
Published: May 2016

The main stages of origin, operation and development of simulation modeling process in sociology based on
consulting activity, as well as simulation models construction methods in the business games’ specifics are
outlined in this paper. The author reveals underexplored problems in sociology at the concrete descriptions
of social technologies for match practice, “decoding” the simulation modeling phenomenon as a consultmanagement
resources. An innovation in this phenomenon understanding is a discovery by the author of
two new functions during its study: structural and training ones. In the sociological encyclopedic dictionary,
where the simulation modeling phenomenon is described, only five of its functions has been stated.
In search of inhospitable knowledge
Authors: Skokic Vlatka , Lynch Paul , Morrison Alison 
Published: May 2016

Abstract
The aim of this article is to discuss the key issues that have had significant influence on a Ph.D. research student’s journey from positivism to interpretivism and the subsequent impact on the research methodology adopted. This journey is illustrated by briefly analysing and reflecting upon the nature of relevant accumulated knowledge in the fields of hospitality, tourism and entrepreneurship fields; critically analysing the impact of the social setting on entrepreneurial behaviours and attitude; and reflecting upon how the two previous points influence researcher behaviour and methodological design. Drawing upon research undertaken within the Dalmatia region of Croatia, a former socialist country, the contextual focus is on small hotel owners within the hospitality industry. The article is loosely framed within a hospitality analytical lens and furthers debate on the nature of academic hospitality (Phipps and Barnett 2007) as well as proposing steps to welcome inhospitable knowledge. This article charts moments in the intellectual journey from positivism to interpretivism travelled by a Ph.D. researcher, who critically engaged in, analysed and deliberated upon the nature of accumulated knowledge associated with the field of her studies, where the power base of the knowledge resided, and consequential issues for advancement of thought. Further, as the journey progressed she reflected on the impact of the social setting of the key actors, which is the focus of her research, and ensuing implications for the research methodological design. In addition, the researcher had to engage in a critical self-reflection that required she transform herself from a ‘dispassionate scientist’ to an ‘insider participant’. The magnitude of this revelation is given context and profound meaning within the setting of Croatia, a former socialist country that has faced severe political, economic and social turmoil and transitions, including war. In making the transformation, the researcher had to engage with inhospitable knowledge from the point of view of her educational formation. In so doing, the article highlights the importance of the boundaries of hospitality and looking at both their construction and exploration beyond.
Vertrauen ist gut, Kontrolle ist besser – Kriterien für Testpapiere zur Qualitätskontrolle in der Mengenentsäuerung nach der neuen ISO / TS 18344
Authors: Potthast Antje , Henniges Ute 
Published: May 2016

Zusammenfassung
Nach einer kurzen Einführung in die Technologie der Papierherstellung und der Mengenentsäuerung werden zunächst die Entwicklungen auf dem Gebiet der Qualitätskontrolle aufgezeigt. Zurzeit sind der pH-Wert, die alkalische Reserve und ihre Verteilung die Hauptkriterien zur Bewertung des Behandlungserfolgs. Da diese destruktiven Messmethoden nicht an Originalobjekten erfolgen können, muss ein universell einsetzbares Testpapier definiert werden. Im Wesentlichen muss dieses Testpapier das Absorptionsverhalten eines Entsäuerungsreagenzes und dessen Reaktionen mit im Papier vorhandenen Säuren darstellen können. Passend dazu müssen entsprechende Messmethoden den Entsäuerungserfolg zweifelsfrei darstellen können. Mit der Kombination von geeignetem Testpapier und spezieller Celluloseanalyse wurde hier im Rahmen der ISO / TS 18344 ein neuer Weg beschritten.
A remark on the multipliers on spaces
of Weak Products of functions
Authors: Richter Stefan , Wick Brett D. 
Published: May 2016

Abstract
If H denotes a Hilbert space of analytic functions on a region Ω ⊆ Cd , then the weak product is defined
by

We prove that if H is a first order holomorphic Besov Hilbert space on the unit ball of Cd , then the multiplier
algebras of H and of H ⊙ H coincide.
Vector-valued holomorphic
and harmonic functions
Authors: Arendt Wolfgang 
Published: May 2016

Abstract
Holomorphic and harmonic functions with values in a Banach space are investigated. Following an
approach given in a joint article with Nikolski [4] it is shown that for bounded functions with values in a Banach
space it suffices that the composition with functionals in a separating subspace of the dual space be holomorphic to
deduce holomorphy. Another result is Vitali’s convergence theorem for holomorphic functions. The main novelty in
the article is to prove analogous results for harmonic functions with values in a Banach space.
Invertible and normal composition operators on the Hilbert Hardy space of a half–plane
Authors: Matache Valentin 
Published: May 2016

AbstractOperators on function spaces of form Cɸf = f ∘ ɸ, where ɸ is a fixed map are called composition operators with symbol ɸ. We study such operators acting on the Hilbert Hardy space over the right half-plane and characterize the situations when they are invertible, Fredholm, unitary, and Hermitian. We determine the normal composition operators with inner, respectively with Möbius symbol. In select cases, we calculate their spectra, essential spectra, and numerical ranges.
Optimization of Facility Layout of Tank farms using Genetic Algorithm and Fireball Scenario
Authors: Nabavi S.R. , Taghipour A.H. , Mohammadpour Gorji A. 
Published: May 2016

Abstract
In this study a novel approach is presented to optimize the layout of petrochemical units, considering the most likely scenario. To illustrate the method a real case study, exporting petrochemical tank farm (Esfahan petrochemical, Iran), was selected. Three objective functions like, piping cost, occupied land cost and human losses were combined and the total cost function was minimized. The required data for lethality function were obtained using simulation of different scenario by Phast software. A sigmoid function was fitted to the data which can estimate the lethality based on the distance from incident point. Genetic algorithm (GA) was used to minimize the total cost function. Due to vastness of searching area, more than one optimum layout was obtained. Finally, the optimum layouts were simulated with fire ball scenario and a good agreement was obtained between optimum points and simulated data.