bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Contribution of Different Cortical Regions to the Control of Spatially Decoupled Eye–Hand Coordination
Authors: Sayegh Patricia F. , Gorbet Diana J. , Hawkins Kara M. , Hoffman Kari L. , Sergio Lauren E. 
Published: March 2017

Abstract
Our brain's ability to flexibly control the communication between the eyes and the hand allows for our successful interaction with the objects located within our environment. This flexibility has been observed in the pattern of neural responses within key regions of the frontoparietal reach network. More specifically, our group has shown how single-unit and oscillatory activity within the dorsal premotor cortex (PMd) and the superior parietal lobule (SPL) change contingent on the level of visuomotor compatibility between the eyes and hand. Reaches that involve a coupling between the eyes and hand toward a common spatial target display a pattern of neural responses that differ from reaches that require eye–hand decoupling. Although previous work examined the altered spiking and oscillatory activity that occurs during different types of eye–hand compatibilities, they did not address how each of these measures of neurological activity interacts with one another. Thus, in an effort to fully characterize the relationship between oscillatory and single-unit activity during different types of eye–hand coordination, we measured the spike–field coherence (SFC) within regions of macaque SPL and PMd. We observed stronger SFC within PMdr and superficial regions of SPL (areas 5/PEc) during decoupled reaches, whereas PMdc and regions within SPL surrounding medial intrapareital sulcus had stronger SFC during coupled reaches. These results were supported by meta-analysis on human fMRI data. Our results support the proposal of altered cortical control during complex eye–hand coordination and highlight the necessity to account for the different eye–hand compatibilities in motor control research.
Weight and Veterans’ Environments Study (WAVES) I and II: Rationale, Methods, and Cohort Characteristics
Authors: Zenk Shannon N. , Tarlov Elizabeth , Powell Lisa M. , Wing Coady , Matthews Stephen A. , Slater Sandy , Gordon Howard S. , Berbaum Michael , Fitzgibbon Marian L. 
Published: March 2017

Purpose: To present the rationale, methods, and cohort characteristics for 2 complementary “big data” studies of residential environment contributions to body weight, metabolic risk, and weight management program participation and effectiveness. Design: Retrospective cohort. Setting: Continental United States. Participants: A total of 3 261 115 veterans who received Department of Veterans Affairs (VA) health care in 2009 to 2014, including 169 910 weight management program participants and a propensity score–derived comparison group. Intervention: The VA MOVE! weight management program, an evidence-based lifestyle intervention. Measures: Body mass index, metabolic risk measures, and MOVE! participation; residential environmental attributes (eg, food outlet availability and walkability); and MOVE! program characteristics. Analysis: Descriptive statistics presented on cohort characteristics and environments where they live. Results: Forty-four percent of men and 42.8% of women were obese, whereas 4.9% of men and 9.9% of women engaged in MOVE!. About half of the cohort had at least 1 supermarket within 1 mile of their home, whereas they averaged close to 4 convenience stores (3.6 for men, 3.9 for women) and 8 fast-food restaurants (7.9 for men, 8.2 for women). Forty-one percent of men and 38.6% of women did not have a park, and 35.5% of men and 31.3% of women did not have a commercial fitness facility within 1 mile. Conclusion: Drawing on a large nationwide cohort residing in diverse environments, these studies are poised to significantly inform policy and weight management program design.
Expression of microRNA let-7a positively correlates with hepatitis B virus replication in hepatocellular carcinoma tissues
Authors: Qiu Dongni , Chen Jian , Liu Jie , Luo Zhongguang , Jiang Weiru , Huang Jianping , Qiu Zhibing , Yue Wenjie , Wu Lijun 
Published: March 2017

Let-7a miRNA is downregulated in various cancers. However, in hepatocellular carcinoma (HCC) patients infected with hepatitis B virus (HBV), the relationship between let-7a and HBV replication has not been fully elucidated. Liver specimens were collected from 23 HCC patients with chronically active HBV. The serum levels of the HBV antigens hepatitis B surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg), and the HBV antibodies, anti-HBs, anti-HBe and anti-hepatitis B core antigen (anti-HBc) were measured using the microparticle enzyme immunoassay. Let-7a levels and HBV DNA copy numbers were measured by quantitative real-time PCR (qRT-PCR) and analyzed statistically. A let-7a specific antisense oligonucleotide was introduced to the HBV-producing cell line HepG2.2.15 and a change in HBV DNA copy numbers was assessed by qRT-PCR. HCC patients with highly active HBV replication (>106 DNA copies/mL) showed higher levels of serum HBsAg and anti-HBc than patients with less active HBV replication (<103 DNA copies/mL). The level of let-7a was lower in malignant tissues than in adjacent normal tissues. However, patients with highly active HBV replication demonstrated a significantly higher level of let-7a in hepatocarcinoma tissue than patients with less active HBV replication ( P < 0.05). A higher level of let-7a was observed in the HBV-producing cell line HepG2.2.15 than in HepG2 cells ( P < 0.05), and let-7a down-regulation by antisense oligonucleotides led to a reduction in HBV DNA copy numbers ( P < 0.05), indicating a correlation between the let-7a level and HBV replication. Down-regulation of let-7a reduces HBV replication and could prevent the development of HCC, suggesting it could be an effective therapeutic treatment for HBV infection. Impact statement Although interferon and nucleic acid analogues effectively suppress HBV replication in HBV patients, there is no treatment which eradicates the virus. Moreover, the therapeutic effect can be reduced by virus mutations or drug resistance. Let-7a is a miRNA initially found in the nematode as a master regulator of developmental processes, but also exists in humans. It has been reported that the transcription of let-7a was much lower in HCC than in normal liver tissues and specific miRNA could directly promote virus replication. Therefore we hypothesized that transcription of let-7a promotes HBV replication, which might compromise the therapeutic effects of antivirus treatments. In our present study, we demonstrated a correlation between let-7a transcription and HBV replication in surgical specimens obtained from patients with HCC, as well as in HCC cell lines. Our finding might be the base for a new approach to improve HBV infection treatments in the future.
Rituximab exposure is influenced by baseline metabolic tumor volume and predicts outcome of DLBCL patients: a Lymphoma Study Association report
Authors: Tout Mira , Casasnovas Olivier , Meignan Michel , Lamy Thierry , Morschhauser Franck , Salles Gilles , Gyan Emmanuel , Haioun Corinne , Mercier Mélanie , Feugier Pierre , Boussetta Sami , Paintaud Gilles , Ternant David , Cartron Guillaume 
Published: March 2017

Key Points
Rituximab exposure decreased as metabolic tumor volume increased, and correlated with metabolic response and survival. Rituximab dose could be individualized according to metabolic tumor volume to achieve optimal exposure and therefore optimal response.
The Limits of Chemical Control in the Caribbean Sugar Factory
Authors: Singerman David Roth 
Published: March 2017

Across the late-nineteenth-century Caribbean, sugar plantations were replaced by centralized industrial factories filled with sophisticated machines. Contemporary observers and later historians have credited those factories and machines with producing sugar of unprecedented purity and consistency. In doing so, they have written sugar's modern history as one of artisan skill replaced by automation. They have also accepted that sugar as a commodity inevitably approaches a sameness that only modern science can measure.This essay argues that the notion that sugar is a globally uniform chemical commodity was equally the product of these factories, showing them to be sites of metrological struggles for control of the labor process. For centuries sugar production had depended on workers' multisensory skills; by claiming that pure sugar was a chemical, industrialists tried to delegitimize these artisans' knowledge and obscure its continuing importance. Far from being automatic, however, the production of chemically pure sugar now depended on the equally hidden work of chemists, whose form of knowledge cane farmers distrusted and turned to the state to regulate. By examining the construction of sugar's apparently universal metrology, this essay suggests how historians can expose the invisible skilled labor that turns nature's diversity into interchangeable goods.
OPTIMIZATION PROCESS OF PRODUCTION PLANNING METHOD OF THE EXPERIMENT
Authors: Серых  , Serykh Inna , Черноситова  , Chernositova Elena , Чернышева  , Chernysheva Elena , Воронцова  , Vorontsova Viktoriya 
Published: March 2017

The results of the planning and implementation of a full factorial experiment on the selection of technological parameters of production special, providing the required values of fat.
The results of the regression analysis allow to identify and assess the influence of components on the fat content of the product process. Set values of technological parameters, allowing to obtain the desired value of the investigated parameter.
The commencement of the limitation period for the unjust enrichment claim: selected issues
Authors: Сергеев Александр , Sergeev Alexander , Терещенко Татьяна , Tereshchenko Tatiana 
Published: March 2017

In this article the authors analyze the concept
of unjust enrichment and certain limitation period issues
about commencement of the limitation period in such a
case. Based on it, the practical application of the conclusions
is demonstrated.
Training for law students: innovational ap proaches due to new Russian educational system
Authors: Писарев Георгий , Pisarev Georgiy 
Published: March 2017

Switching to a two-tiered training learning has established
a number of problematic issues. The author makes proposals on the
application of new teaching methods. Activization of the teaching
staff is needed for their implementation. The necessity of standardization
of the minimum content of the methodological support of
the master’s programs is substantiated.
«Space» of civil legislation as a problem of development of private law
Authors: Серова Ольга , Serova Olga 
Published: March 2017

Monopolization and expansion of civil law has no clear
designation in science. But the problem of expanding of spatial boundaries
of private law does exist. Introduction of division of legal entities
and corporations unitary organization will have a serious impact on the
expansion of private law in the area of labor law. The author denotes
the problem of expanding forms of participation of the state in the sphere
of private law.
The problem of pecuniary nature of relation ships, included in the subject matter of civil law
Authors: Рузанова Валентина , Ruzanova Valentina 
Published: March 2017

The article is dedicated to revealing the essence of pecuniary
relationships as part of the subject matter of civil law. Based on the
analysis of existing doctrinal approaches the author ascertains attributes
of these relationships and formulates their definition. The author reveals
connection of civil legal relationship (subjective civil rights) with the
subject matter of civil law, and for the first time in the literature it is
concluded that they have common classification criterion. In the text
the main groups of pecuniary relations regulated by different subbranches
and institutes of civil law are determined. It is noted that
civil forms of expression of pecuniary relationships are diverse.
Absolute relations in the subject of civil law
Authors: Арсланов Камиль , Arslanov Kamil 
Published: March 2017

The article studies one of the central categories of civil law,
which is civil legal relations. The category of legal relations that builds
the subject of civil law, that receives the cleared fixation in legal acts, including
the unified acts (Civil Code of the Russian Federation), causes
until present time different discussions in the civil legal science. This is
indicated of scientific researches of Soviet and Russian scientists since
middle of 20th century.
The fundamental division of legal relations into absolute and relative
relations tries to earn our interest because of its practical significance.
Depending of rating of legal relations to specified kind the optimal
mechanism of legal influence on participants of legal relations using of
private and / or public legal instruments is defined. Inspite of all these,
the subject of this article are first of all absolute legal relations. The author
tried to generalize existing concepts in the science of civil law about absolute
legal relations, to define the possibility to differentiate absolute and
relative legal relations. The question about the possibility of existence of
legal relations with elements of absoluteness and relativity, parallel existence
of absolute and relative legal relations in connection to the same
subject is raised. The specific character of absolute legal relations is analyzed
in connection with proprietary legal regulation, regulation in the
field of intellectual property rights, protection of immaterial goods and
immaterial rights, as well as in connection with relative new field of legal
regulation of corporate legal relations.
In the article the conclusion about the necessity of resumption of scientific
discussion concerning the essence of absolute legal relations and
necessity of their cleared definition ad litem is made.
Managing data subject access requests
Authors: Griffith Richard 
Published: March 2017

The Data Protection Act 1998 requires district nurses to process personal patient data fairly and lawfully by keeping accurate, contemporaneous and secure records. Patients who have concerns about the accuracy of their record can seek access to the record under the 1998 Act. In this article, Richard Griffith considers the requirements for requesting and granting access to a patient to view and obtain a copy of their health record.
Exploring postnatal depression, sexual dysfunction and relationship dissatisfaction in Australian women
Authors: Khajehei Marjan , Doherty Maryanne 
Published: March 2017

Background Postnatal depression symptoms are the most common mental health problem following childbirth. Aims This study aimed to investigate the association between sexual dysfunction, relationship dissatisfaction and symptoms of postnatal depression among Australian women during the first year after giving birth. Methods Australian women who had given birth during the past 12 months were invited to participate in a cross-sectional online study. A multi-section questionnaire was designed to collected data. Findings Almost a quarter of respondents (24%) reported symptoms of postnatal depression. The symptoms of postnatal depression were significantly associated with low educational level, exclusive breastfeeding, clinically diagnosed depression, sexual dysfunction, not being the initiator of sex during partnered sexual activity, and relationship dissatisfaction. The risk of depression symptoms was 2.2 times greater in women who had a low level of education, 2.5 times greater in women with sexual dysfunction and 3.7 times greater in women with relationship dissatisfaction. Conclusions Symptoms of depression are prevalent among postnatal women during the first year after childbirth and are significantly associated with sexual dysfunction and relationship dissatisfaction.
The current situation in hip arthroscopy
Authors: Marin-Peña Oliver , Tey-Pons Marc , Perez-Carro Luis , Said Hatem G. , Sierra Pablo , Dantas Pedro , Villar Richard N. 
Published: March 2017

Hip arthroscopy is an evolving surgical technique that has recently increased in popularity. Although femoroacetabular impingement was an important launch pad for this technique, extra-articular pathology has been described through hip endoscopy. Good clinical results in the medium term will allow improvements in this technique and increase its indications. Cite this article: EFORT Open Rev 2017;2:58-65. DOI: 10.1302/2058-5241.2.150041
The effectiveness of extended fetal heart screening in a Tertiary Center
Authors: Çakır Fatma , Şık Bulat Aytek , Kumbasar Serkan , Bozkurt Murat , Aba Yılda Arzu 
Published: March 2017

Our study is to evaluate the effectiveness of extended fetal heart screening in a tertiary center and research the sensitivity, specifity and the positive and negative values of echocardiography.316 patients who were diagnosed with congenital anomalies among those scanned with the extended fetal heart screening protocol in the perinatology department of our hospital were included in our study. Patients who were not diagnosed with congenital anomalies were excluded. Fetal echocardiographies were perfomed on patients who were admitted to our perinatology clinic, in accordance with the ISUOG extended fetal heart screening protocol. In our study, 55.3% of all cases with cardiac anomalies are concomitant with extracardiac anomalies. An interventional procedure was performed on 52.5% of the patients for karyotyping purposes. 19.3% was terminated early in the pregnancy, 5% and 12.5% were lost during the intrauterine and neonatal periods, respectively. In our study, upon comparison of the fetal and neonatal results, we determined that the false positive and negative rates for fetal echocardiography were 3.5% and 9.4% respectively.In our study, the sensitivity, specificity, positive predictive value and accuracy of echocardiography were determined as 91%, 99%, 98% and 99% respectively during the application of ISUOG recommendations in a tertiary center.
THE EFFECT OF CALF STARTER RATION FOR PRE-WEANING ONGOLE GRADE (PO) CALVES ON BODY WEIGHT GAIN
Authors: Winarti E. , Widyastuti A. 
Published: March 2017

The objective of study was to determine the effect of calf starter in the pre-weaning calves against the daily body weight gain. Twenty Ongole grade (PO) calves age of 1 month divided into 4 treatment groups of feed, 5 calves for each treatment. Treatment (P1) fed with extra soybean groats; (P2) soybean groats 50% + Gliricidia 50%; (P3) soybean groats 50%+ rice bran 50%; (P4) soybean groats 50%+ rejected bread 50%. Calf starter was given at age 1 month to 3 months. Observation was carried out on calves daily weight gain. This experiment was designed in Completely Randomized Design. Data was analyzed by analysis of variance and continued Least Significant Difference Test. Statistical analysis showed that feed of (P <0.05) significantly affected the daily weight gain of the calves. Results of the study can be concluded that calf starter with soya groats provide the best daily weight gain of pre-weaning calf.
SINTESIS ASAM 9,10-DIHIDROKSI STEARAT (DHSA) MELALUI HIDROLISA EPOKSIDA DARI OKSIDASI ASAM OLEAT DENGAN ASAM PERFORMAT
Authors: Maisaroh Maisaroh , Susetyo Indra Budi , Rusmandana Bayu 
Published: March 2017

SYNTHESIS OF 9,10-DIHYDROXYSTEARIC ACID (DHSA) THROUGH HYDROLYSIS EPOXIDE FROM OXIDATION OLEIC ACID AND PERFORMIC ACID. 9,10-dihydroxy stearic acid (DHSA); C18H36O4 is one of hydroxyl fatty acids with hydroxyl groups (OH) and carboxyl groups (-COOH) cause DHSA have unique properties for many applications including as an emulsifier in the oil phase/gel candles and water in cosmetic formulations. This study investigated the formation of DHSA of from oleic acid and performic acid through epoxidation and hydrolysis reactions. Epoxidation was carried out by reacting the oleic acid with formic acid to form performic acid in situ reaction at a temperature of 60-70oC with stirring in order to minimize byproduct, followed hydrolysis obtained DHSA as powder with melting point 86.5oC, iodine value 0.125 g I2/100 g, acid value 171.53 mg KOH/g, the hydroxyl group observed at the absorption band region of 3345.34 cm-1, LCMS analysis results show peak spetrograms-mass at m/z 317,269, with a value m/z is equivalent to molecular weight DHSA. Keywords: DHSA; epoxidation; hydrolysis; hydroxyl fatty acids; oleic acid Abstrak Asam 9,10-dihidroksi stearat (DHSA) dengan rumus molekul C18H36O4 merupakan senyawa hidroksil asam lemak dengan gugus hidroksil (-OH) dan karboksil (-COOH) menyebabkan DHSA memiliki sifat unik untuk berbagai aplikasi antara lain sebagai emulsifier antara fasa minyak/lilin gel dan air dalam formulasi kosmetik. Penelitian ini bertujuan untuk menghasilkan DHSA dari asam oleat dan asam performat, melalui tahapan reaksi epoksidasi dan hidrolisa. Epoksidasi asam oleat dengan asam performat yang dibentuk secara in situ dilakukan pada suhu reaksi 60-70oC dengan pengadukan untuk meminimalkan reaksi samping, dilanjutkan dengan hidrolisa epoksida diperoleh DHSA berupa serbuk berwarna putih gading dengan titik leleh 86,5oC, bilangan iod ± 0,125 g I2/100 g, bilangan asam 171,53 mg KOH/g, gugus hidroksil teramati menggunakan FTIR pada bilangan gelombang 3345,34 cm-1, yang diperkuat dengan data kromatogram LC-MS yang memberikan puncak spektrogram-massa pada m/z 317.269, dengan harga m/z yang setara dengan Berat Molekul DHSA. Kata kunci: DHSA; epoksidasi; hidrolisa; hidroksil asam lemak; asam oleat
PENGARUH PENGERINGAN DENGAN METODE GELEMBUNG TERHADAP SIFAT FISIK PRODUK EKSTRAK BUNGA ROSELA
Authors: Djaeni Mohamad , Triyastuti Meilya Suzan , Rahardjo Hadiono Soegeng 
Published: March 2017

Bunga rosela mengandung senyawa antosianin berwarna merah yang kaya antioksidan. Senyawa ini dapat diekstrak dan dikemas dalam bentuk serbuk kering sebagai bahan pewarna makanan dan minuman. Produksi serbuk ekstrak bunga rosela dengan pengeringan konvensional masih menghadapi kendala karena sifatnya yang tidak tahan panas. Penelitian ini bertujuan untuk mempelajari pengaruh pengeringan dengan metode gelembung terhadap sifat fisik ekstrak bunga rosela. Pada proses ini, bunga rosela diekstrak dengan air pada perbandingan 1:10 pada suhu 50oC selama 1 jam. Filtrat yang kaya antosianin dicampur dengan bahan pembentuk gelembung (putih telur) dan penstabil yaitu gliserol mono stearat (GMS). Campuran ini kemudian dikeringkan dengan udara pada temperatur yang berbeda. Dibandingkan dengan pengeringan ekstrak roselle tanpa gelembung, adanya putih telur dan GMS mampu mempercepat proses penguapan air dari ekstrak yang dikeringkan. Penguapan menjadi lebih cepat pada suhu yang lebih tinggi. Namun demikian, dari penampakan fisik terlihat bahwa pada suhu diatas 70oC, warna ekstrak mulai kehitam-hitaman (akibat karbonasi), serta serbuk yang dihasilkan lebih rapuh