bluuebunny/crossref_metadata_2025_split huggingface dataset:
TIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T Cells
Authors: Priego Neibla , de Pablos-Aragoneses Ana , Perea-García María , Pieri Valentina , Hernández-Oliver Carolina , Álvaro-Espinosa Laura , Rojas Andrea , Sánchez Oliva , Steindl Ariane , Caleiras Eduardo , García Fernando , García-Martín Santiago , Graña-Castro Osvaldo , García-Mulero Sandra , Serrano Diego , Velasco-Beltrán Paloma , Jiménez-Lasheras Borja , Egia-Mendikute Leire , Rupp Luise , Stammberger Antonia , Meinhardt Matthias , Chaachou-Charradi Anas , Martínez-Saez Elena , Bertero Luca , Cassoni Paola , Mangherini Luca , Pellerino Alessia , Rudà Roberta , Soffietti Riccardo , Al-Shahrour Fatima , Saftig Paul , Sanz-Pamplona Rebeca , Schmitz Marc , Crocker Stephen J. , Calvo Alfonso , Palazón Asís ,   RENACER, Valiente Manuel 
Published: October 2024

Abstract
Immunotherapies against brain metastases have shown clinical benefits when applied to asymptomatic patients, but they are largely ineffective in symptomatic cases for unknown reasons. Here, we dissect the heterogeneity in metastasis-associated astrocytes using single-cell RNA sequencing and report a population that blocks the antitumoral activity of infiltrating T cells. This protumoral activity is mediated by the secretion of tissue inhibitor of metalloproteinase-1 (TIMP1) from a cluster of pSTAT3+ astrocytes that acts on CD63+ CD8+ T cells to modulate their function. Using genetic and pharmacologic approaches in mouse and human brain metastasis models, we demonstrate that combining immune checkpoint blockade antibodies with the inhibition of astrocyte-mediated local immunosuppression may benefit patients with symptomatic brain metastases. We further reveal that the presence of tissue inhibitor of metalloproteinase-1 in liquid biopsies provides a biomarker to select patients for this combined immunotherapy. Overall, our findings demonstrate an unexpected immunomodulatory role for astrocytes in brain metastases with clinical implications.
Significance: This study presents a significant advancement in understanding immune modulation in brain tumors and offers new insights into the potential therapeutic interventions for brain metastases.
See related commentary by Lorger and James, p. 11
Redescription of Rhabditis maupasi Seurat in Maupas, 1919 (Rhabditida: Rhabditidae) from northwest Iran
Authors: Vazifeh Nasir , Niknam Gholamreza , Abolafia Joaquín , Shokoohi Ebrahim 
Published: October 2024

Summary
Rhabditis maupasi is re-described and reviewed based on morphological, morphometric, and molecular (D2-D3 expansion segment of the rDNA 28S) analysis collected from northwest Iran. The species is characterised by having a 1.1-1.9 mm long body, lateral fields with three incisures, the lip region offset by a depression, 12-15 μm wide, with six globular lips, the stoma rhabditoid, 14-20 μm long, with distinct cheilo-, gymno- and stegostom; cheilostom slightly cuticularised, gymno-promesostegostom a short tube with well-cuticularised walls, metastegostom with glottoid apparatus bearing small teeth, stomatal or pharyngeal collar covering 40-60% of stoma; pharynx well developed, the pharyngeal corpus consisting of a more or less cylindrical procorpus and swollen metacorpus (median bulb), basal bulb ovoid to pyriform, with grinder and narrow haustrulum, excretory pore at basal bulb level; vulva a transverse slit with protruding lips, the female tail conical-elongated (65-75 μm, c = 16-26, c′ = 2.0-2.5), the male tail conoid, ventrally arcuate (29-34 μm, c = 22-41, c′ = 0.7-1.0); spicules free, with pointed end and dagger-shaped, 61-72 μm long, bursa pseudopeloderan, and with eight pairs of genital papillae plus the phasmid, and gubernaculum 34-36 μm long. Furthermore, its relationship with four closely related species of the genus is discussed. A molecular phylogenetic study using a partial sequence of large subunit ribosomal DNA fragments revealed that R. maupasi forms a clade with R. terricola, recorded previously from Iran.
Promoting ASEAN Integration
Authors: Ha Hoang Hai , Ha Nguyen An , Khanh Do Ta 
Published: October 2024

Abstract
This article analyses Vietnam’s proactive and in-depth integration in the Association of Southeast Asian Nations (ASEAN), with a particular focus on the first decades of the 21st century. The paper argues that Vietnam’s more active and largely responsible contributions to ASEAN integration are fundamentally shaped by its perceptions on opportunities and challenges caused by China’s rise. By maintaining ASEAN’s non-aligned status, reinforcing its strategic autonomy, centrality, and unification, Vietnam seeks to make the Association strong enough to take a unified position towards China’s aggressive behaviour in the disputed waters close to its shores. However, ASEAN’s internal limitations, China’s great power diplomacy, and geo-strategic constraints, as well as countervailing incentives, lead us to expect there will be further challenges to Vietnam’s efforts.
Green Facades
Authors: Nadalutti Elisabetta 
Published: October 2024

Abstract
This article examines the development of ‘Forest City’ in the Iskandar Malaysia development Corridor within the broader context of China’s international expansion, focusing on Forest City portrayal as a model of sustainability. Despite being promoted as ‘eco-cities’ and ‘green cities’, these mega-projects often fall short of these ideals, revealing a significant gap between their marketed image and their actual environmental practices (Ouis 2011). Through the lens of Practice Theory enriched by the developmental state model, this study analyses the alignment between the promotional rhetoric of Chinese-backed green city projects and their real-world execution. Practice Theory offers a valuable tool for identifying inconsistencies between stated commitments to sustainability and the tangible outcomes observed in Chinese-finance development projects in Southeast Asia. The developmental state model helps to understand the practices that are translated, transplanted, and embedded by Chinese developers across borders. This analytical framework is critical as it sheds light on the underlying dynamics of ‘global China’ initiatives, which have gained increased global attention. Such scrutiny is particularly pertinent in highlighting the contrast between the marketed sustainability of these cities and the principles of genuine sustainable development. This critique provides a deeper understanding of the environmental implications of China’s overseas investments. Based on this analysis, the overarching research question is: why do Chinese-backed green city projects, such as Forest City in Iskandar Malaysia, frequently exhibit discrepancies between their promoted environmental sustainability and the actual environmental outcomes?
Theorizing and Understanding Corporate Involvement in Atrocity Crimes
Authors: van Baar Annika 
Published: October 2024

Abstract
Corporate involvement in atrocity crimes such as genocide, crimes against humanity and war crimes, has become an important topic for ngo s, activists and scholars from different disciplines, often focusing on the important question how to achieve a better regulation of and accountability for corporate roles in atrocities. This contribution, instead, is focused on the aetiology of this phenomenon. A theoretical framework is proposed based on, on the one hand, what follows from criminological research on corporate crime, state crime and state-corporate crime and, on the other hand, in-depth case studies of three contexts: Nazi Germany (1933–1945), Apartheid South Africa (1948–1994) and the drc (1996–2016). The proposed framework identifies the motivational drivers, opportunity aspects, and elements of the (lack of) control that, together, can explain why that corporation became involved in atrocity crimes. The framework is intended to—through application to new case studies—improve knowledge about and understanding of corporate involvement in atrocity crimes and to expand the conceptual and theoretical understanding of this phenomenon.
Evaluating Biophilic Design’s Effects on Virtual Museum Perception and Behavior
Authors: Dalay Lâl , Aytaç Gülşen 
Published: October 2024

Abstract
This study explores how the experience in virtual reality of localities such as museum spaces or digital museum environments can be enhanced by biophilic design, in the context of the COVID-19 pandemic which has significantly changed the way people interact with the built environment. The research focuses on the potential effects of biophilic design elements on human behavior, perception of space, and emotional response in digital museum environments, such as the Nature, Gardens, Fantasies exhibition at the Arkas Art Center. Integrating natural shapes and forms, light, and space into digital spaces can serve as a guide for design solutions that combine nature, art, and technology to promote an internal experience of nature. The study examines the impact of biophilic design elements on individuals’ perceptions and behaviors in virtual museum settings and emerging concepts of biophilia and exhibition environments are presented. These interactions and experiences with the exhibition were reported by the participants through a questionnaire. The impact of the digital exhibition’s biophilic design on participants’ sense of orientation, space, emotions, and general well-being was examined in this study. The results showed important aspects of the design that affected these variables. The majority of participants reported feeling content, at ease, and joyful following the virtual experience, despite the fact that their emotional reactions varied. This suggests that virtual biophilic design is effective in replicating the positive impacts of physical biophilic places. According to the research, virtual places can mimic the benefits of real-world biophilic spaces and have the ability to effectively promote biophilic design. Digital interventions present a great possibility for improving human well-being through the integration of technology, art, and nature. This is especially important in view of challenges like the COVID-19 outbreak.
Effects of powderization of a granular diet on growth performance of the edible cricket, Teleogryllus occipitalis (Orthoptera: Gryllidae)
Authors: Murata K. , Kagesawa W. , Akechi M. , Morimitsu Y. , Suzuki T. 
Published: October 2024

Abstract
Farming edible crickets has environmental and nutritional benefits, as well as social benefits such as livelihood diversification. Commercial feeds for poultry and fish farming are often used to feed crickets, and in recent years, crop and food-processing by-products have also been used to improve sustainability. However, the design of feed for crickets has not been standardized. Here, we investigated growth and development of the Asian field cricket, Teleogryllus occipitalis (Audinet-Serville) (Orthoptera: Gryllidae), fed on different forms of the same diet. Body mass and the rate of development were significantly greater in crickets fed on millimetre-order granules than in crickets fed on micrometre-order powder. In addition, analysis of feeding behaviour revealed that crickets fed less frequently on the powdered diet than on the granulated diet. These results suggest that crickets have an avoidance behaviour towards fine particles, or that the granular form is easier for them to grasp and ingest than the powdery form, which may have contributed to growth performance. Simply feeding millimetre-order granules may contribute to the development of feed design for farming edible crickets.
Hexaplaric Variants to the Books of Job, Proverbs, and Canticum
Authors: Albrecht Felix 
Published: October 2024

Abstract
This article offers an inaugural analysis of the Septuagint manuscript Rahlfs 516 (Codex Athous Lavra 149), a codex of the libri sapientiales from the second half of the tenth century, previously misdated and overlooked in Septuagint editions. The manuscript contains five Wisdom books of the Septuagint: Job, Sirach, a prologue to the book of Proverbs, Proverbs, Ecclesiastes, and Canticum. This manuscript, distinguished for its Hexaplaric readings in Job and its extensive parallels with Ra 248 and Ra 161, presents attributions to the Jewish revisers Aquila, Symmachus, and Theodotion. The analysis of this manuscript reveals interesting variants and a novel Symmachus reading in Job 1:6c, as well as a Symmachus attestation in Job 1:16b and a new Hexaplaric reading for Job 15:21b. This study accentuates the imperative of integrating Ra 516 into scholarly discourse and shows its significance for future research.
Reevaluation and Renewed Readings
Authors: Golani Shira J. 
Published: October 2024

Abstract
The pericope of David’s heroes is a scholarly junction of textual variation and literary-historical details regarding the military unit of David’s Heroes. This article reevaluates the spectrum of extant textual variants relating to the literary structure of this pericope in its two occurrences, at 2 Sam 23:8–39 and 1 Chr 11:11–47, with emphasis on the question of “warriors of the third rank,” with the aim of arriving at a better understanding of the structure of both the literary pericope and the military unit it describes. The textual reevaluation leads to the conclusion that, contrary to the preferred status of MT-Samuel in leading literary-historical studies, readings extant in other versions are to be preferred, while unique MT-Samuel readings, and the historiographical information they reflect, should be understood as either corruptions, reflections of a secondary tradition, or interpretation.
Violence, Affect, Empathy: The Topos of Immurement in Bulgarian School Textbooks
Authors: Siedlecka Sylwia 
Published: October 2024

Violence, Affect, Empathy: The Topos of Immurement in Bulgarian School Textbooks
The article examines the presence of the topos of foundation sacrifice in Bulgarian school textbooks since the 1970s, as well as media discussions on the function and meaning of this topos in the teaching of primary school children. Local culture is an important part of the Bulgarian education system, and textbook interpretations of the song about immurement entitled Three Brothers Built a Fortress have been a regular part of the core curriculum for half a century. Textual and performative interpretations of the song Three Brothers Built a Fortress analysed in this article make it possible to track the key ways in which textbook authors have understood the topos of the foundation sacrifice over the last half-century. The analysis of key interpretations of the song Three Brothers Built a Fortress in textbooks and of accompanying performative strategies show that education remains a space for the normalisation of violence against women and the perpetuation of gender inequalities. Embedded in men’s stories, women are supporting characters that stabilise the male world but lack a significant voice or empowerment. The sacrifice of a woman is sometimes judged as equitable and noble, and an acquiescent, obedient death is judged as desirable to achieve a higher goal. Legitimisation of the sacrificial act in the song Three Brothers Built a Fortress is an analogy for defining the Bulgarian nation as a community in need of sacrifice and a way of legitimising ethnic nationalism.

Przemoc, afekt, empatia. Topos zamurowania w bułgarskich podręcznikach szkolnych
W artykule zanalizowano obecność toposu ofiary zakładzinowej w bułgarskich podręcznikach szkolnych od lat 70. XX wieku do współczesności oraz dyskusje medialne na temat funkcji i znaczenia tego toposu w nauczaniu dzieci w szkołach podstawowych. Kultura lokalna jest istotną częścią bułgarskiego systemu edukacji, a podręcznikowe interpretacje pieśni o zamurowaniu pod tytułem Trzej bracia budowali twierdzę od półwiecza są stałym elementem podstawy programowej. Analizowane w artykule tekstowe i performatywne interpretacje pieśni o zamurowanej pozwalają prześledzić kluczowe sposoby rozumienia przez autorów podręczników toposu ofiary zakładzinowej w perspektywie ostatniego półwiecza. Analiza kluczowych sposobów interpretowania pieśni w podręcznikach oraz towarzyszące im strategie performatywne pokazują, że edukacja nadal pozostaje przestrzenią normalizacji przemocy wobec kobiet i utrwalania nierówności genderowych. Osadzone w męskich opowieściach kobiety są postaciami pomocniczymi, stabilizującymi męski świat, ale nieposiadającymi istotnego głosu ani sprawczości. Ofiara złożona z kobiety bywa oceniana jako słuszna i wzniosła, a pokorna, pozbawiona buntu śmierć jako pożądana w imię uzyskania wyższego celu. Legitymizacja aktu ofiarniczego w pieśni jest analogią dla definiowania narodu bułgarskiego jako wspólnoty potrzebującej ofiar oraz sposobem legitymizacji nacjonalizmu etnicznego.
Adaptations of Chekhov’s “A Boring Story” in Polish Cinema
Authors: Trashchynskaya-Stsiapushyna Tatsiana 
Published: October 2024

Adaptations of Chekhov’s A Boring Story in Polish Cinema
The article discusses the specifics of the adaptation of a work of Russian classical literature in the cinematography of Poland. The object of interest is A. P. Chekhov’s novel A Boring Story (1889), and its adaptation Nieciekawa historia by W. E. Has (1982). The term “adaptation” is broader than the translation of one artistic system into the language of another. The main problems of film adaptation are identified: the contradiction between a literal illustration of the original source and the director’s departure into greater artistic independence from the writer’s plan; the increasing commercialization of cinema; the difference of epochs; ethnocultural differences between the writer and the director; the use of cinema as a means of propaganda. It is argued that the adaptation of a literary work of Russian classical literature by a director of another culture living in another time gives birth to a new, independent work of cinematic art in which new meanings are added to the meanings of the literary source that have arisen precisely due to the peculiarities of film language.

Adaptacja opowiadania Nieciekawa historia Antona Czechowa w kinie polskim
Artykuł poświęcony jest kwestii specyfiki ekranizacji klasycznych dzieł rosyjskiej literatury w kinematografii polskiej. Przedmiotem uwagi jest opowiadanie Antona Czechowa Nieciekawa historia (1889) oraz jej ekranizacja Nieciekawa historia, autorstwa Wojciecha E. Hasa (1982). Pojęcie adaptacji filmowej (ekranizacji) jest rozumiane jako coś więcej niż tłumaczenie jednego systemu artystycznego na inny. W artykule zostały przedyskutowane główne problemy tego aktu: sprzeczność między dosłownym ilustrowaniem źródła a decyzją reżysera o odejściu od intencji pisarza w kierunku większej niezależności artystycznej, rosnąca komercjalizacja kina, różnica epok, różnice etnokulturowe między pisarzem i reżyserem, wykorzystanie kina jako środka propagandy. Pokazano, jak adaptacja dzieła literackiego klasycznej literatury rosyjskiej przez reżysera z innej kultury, żyjącego w innym czasie, rodzi nowe, niezależne dzieło sztuki filmowej, w którym do znaczeń źródła literackiego dodawane są nowe znaczenia i że powstały one właśnie ze względu na specyfikę języka filmowego.
Nontuberculous mycobacterial pulmonary disease (NTM PD) incidence trends in the United States, 2010–2019
Authors: Bents Samantha J. , Mercaldo Rachel A. , Powell Collin , Henkle Emily , Marras Theodore K. , Prevots D. Rebecca 
Published: October 2024

Abstract
Background
Nontuberculous mycobacteria (NTM) are ubiquitous environmental bacteria that cause chronic lung disease. Rates of NTM pulmonary disease (NTM PD) have increased over the last several decades, yet national estimates in the United States (US) have not been assessed since 2015.

Methods
We used a nationally representative population of Medicare beneficiaries aged ≥ 65 years to assess rates of NTM PD in a high-risk population from 2010 to 2019. Poisson generalized linear models were used to assess the annual percent change in incidence in the overall population and among key demographic groups such as sex, geography, and race/ethnicity. We evaluated the relative prevalence of various comorbid conditions previously found to be associated with NTM PD.

Results
We identified 59,724 cases of incident NTM PD from 2010 to 2019 from an annual mean population of 29,687,097 beneficiaries, with an average annual incidence of 20.1 per 100,000 population. NTM PD incidence was overall highest in the South and among women, Asian individuals, and persons aged ≥ 80 years relative to other studied demographic groups. The annual percent change in NTM PD incidence was highest in the Northeast, at 6.5%, and Midwest, at 5.9%, and among women, at 6.5%. Several comorbid conditions were highly associated with concurrent NTM diagnosis, including allergic bronchopulmonary aspergillosis, bronchiectasis, and cystic fibrosis.

Conclusions
Here we provide current estimates of NTM PD incidence and prevalence and describe increasing trends in the US from 2010 to 2019. Our study suggests a need for improved healthcare planning to handle an increased future caseload, as well as improved diagnostics and therapeutics to better detect and treat NTM PD in populations aged ≥ 65 years.
Drivers and barriers of seasonal influenza vaccination 2015/16 & 2019/20 to 2022/23 - a survey on why most Norwegians don’t get the flu vaccine
Authors: Klüwer Birgitte , Rydland Kjersti Margrethe , Mamelund Svenn-Erik , Gleditsch Rebecca Nybru 
Published: October 2024

Abstract
Background
This study aimed to explore the reasons adults in the general population, influenza risk groups (RGs) and health care workers (HCWs) in Norway give for their vaccination choices and whether these reasons vary between groups or over time in order to further improve influenza vaccination coverage.

Methods
Respondents of a nationally representative telephone survey conducted by Statistics Norway were asked “What was the most important reason why you did/did not get vaccinated?”. The question on influenza non-vaccination was included in 2016 and in 2020 to 2023 and the question on influenza vaccination in 2021 to 2023.

Results
The study included 9 705 individuals aged 18–79 years. Influenza vaccination coverage in the RGs increased from 20.6% in 2016 to 63.1% in 2022, before a reduction to 58.3% in 2023. Common reasons for non-vaccination were similar in all groups. The most cited reasons were “no need” for the vaccine and “no specific reason”, followed by “not recommended/offered the vaccine”, “worry about side effects” and “vaccine refusal”. The most frequent reasons for vaccination among the general population and RGs were protection against influenza and belonging to a RG, while the most frequent responses among HCWs were being offered the vaccine at work/work in health care, followed by a desire for protection against influenza. Receiving a vaccine recommendation from a health professional was mentioned in all groups. We also observed that the proportion reporting “no need” for the vaccine decreased over time, especially among HCWs, and that the proportions reporting vaccine refusal and worry about side effects as reasons for non-vaccination were temporarily reduced during the COVID-19 pandemic.

Conclusions
The general population and RGs cite protection against influenza as their primary incentive for vaccination, while HCWs mainly refer to their professional role or workplace vaccination. For non-vaccination we see a similar pattern in all groups, with “no need” and “no specific reason” as the main reasons. Of note, worry about side effects and vaccine refusal is as frequent among HCWs as in other groups. Continued efforts to maintain and increase vaccine confidence are needed.