bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interfering with the Chronic Immune Response Rescues Chronic Degeneration After Traumatic Brain Injury
Authors: Ertürk Ali , Mentz Susanne , Stout Erik E. , Hedehus Maj , Dominguez Sara L. , Neumaier Lisa , Krammer Franziska , Llovera Gemma , Srinivasan Karpagam , Hansen David V. , Liesz Arthur , Scearce-Levie Kimberly A. , Sheng Morgan 
Published: September 2016

After traumatic brain injury (TBI), neurons surviving the initial insult can undergo chronic (secondary) degeneration via poorly understood mechanisms, resulting in long-term cognitive impairment. Although a neuroinflammatory response is promptly activated after TBI, it is unknown whether it has a significant role in chronic phases of TBI (>1 year after injury). Using a closed-head injury model of TBI in mice, we showed by MRI scans that TBI caused substantial degeneration at the lesion site within a few weeks and these did not expand significantly thereafter. However, chronic alterations in neurons were observed, with reduced dendritic spine density lasting >1 year after injury. In parallel, we found a long-lasting inflammatory response throughout the entire brain. Deletion of one allele of CX3CR1, a chemokine receptor, limited infiltration of peripheral immune cells and largely prevented the chronic degeneration of the injured brain and provided a better functional recovery in female, but not male, mice. Therefore, targeting persistent neuroinflammation presents a new therapeutic option to reduce chronic neurodegeneration.SIGNIFICANCE STATEMENTTraumatic brain injury (TBI) often causes chronic neurological problems including epilepsy, neuropsychiatric disorders, and dementia through unknown mechanisms. Our study demonstrates that inflammatory cells invading the brain lead to secondary brain damage. Sex-specific amelioration of chronic neuroinflammation rescues the brain degeneration and results in improved motor functions. Therefore, this study pinpoints an effective therapeutic approach to preventing secondary complications after TBI.
Involvement of Spinal IL-6Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-Alpha
Authors: König Christian , Morch Eric , Eitner Annett , Möller Christian , Turnquist Brian , Schaible Hans-Georg , Ebersberger Andrea 
Published: September 2016

During peripheral inflammation, both spinal TNF-α and IL-6 are released within the spinal cord and support the generation of inflammation-evoked spinal hyperexcitability. However, whether spinal TNF-α and IL-6 act independently in parallel or in a functionally dependent manner has not been investigated. In extracellular recordings from mechanonociceptive deep dorsal horn neurons of normal ratsin vivo, we found that spinal application of TNF-α increased spinal neuronal responses to mechanical stimulation of knee and ankle joints. This effect was significantly attenuated by either sgp130, which blocks IL-6trans-signaling mediated by IL-6 and its soluble receptor IL-6R (sIL-6R); by an antibody to the IL-6 receptor; or by minocycline, which inhibits the microglia. IL-6 was localized in neurons of the spinal cord and, upon peripheral noxious stimulation in the presence of spinal TNF-α, IL-6 was released spinally. Furthermore, TNF-α recruited microglial cells to provide sIL-6R, which can form complexes with IL-6. Spinal application of IL-6 plus sIL-6R, but not of IL-6 alone, enhanced spinal hyperexcitability similar to TNF-α and the inhibition of TNF-α-induced hyperexcitability by minocycline was overcome by coadministration of sIL-6R, showing that sIL-6R is required. Neither minocycline nor the TNF-α-neutralizing compound etanercept inhibited the induction of hyperexcitability by IL-6 plus sIL-6R. Together, these data show that the induction of hyperexcitability of nociceptive deep dorsal horn neurons by TNF-α largely depends on the formation of IL-6/sIL-6R complexes that are downstream of TNF-α and requires the interactions of neurons and microglia orchestrated by TNF-α.SIGNIFICANCE STATEMENTBoth spinal TNF-α and IL-6 induce a state of spinal hyperexcitability. We present the novel finding that the full effect of TNF-α on the development of spinal hyperexcitability depends on IL-6trans-signaling acting downstream of TNF-α. IL-6trans-signaling requires the formation of complexes of IL-6 and soluble IL-6 receptor. Spinal TNF-α furthers the release of IL-6 from neurons in the spinal cord during peripheral noxious stimulation and recruits microglial cells to provide soluble IL-6 receptor, which can form complexes with IL-6. Therefore, a specific interaction between neurons and microglia is required for the full development of TNF-α-induced hyperexcitability of nociceptive deep horsal horn neurons.
DDX3 Modulates Neurite Development via Translationally Activating an RNA Regulon Involved in Rac1 Activation
Authors: Chen Hung-Hsi , Yu Hsin-I , Tarn Woan-Yuh 
Published: September 2016

The RNA helicase DDX3 is a component of neuronal granules, and its gene mutations are linked to intellectual disability (ID). Here we demonstrate that DDX3 depletion in neurons impairs neurite development by downregulating Rac1 level and activation. Moreover, DDX3 activates the translation of functionally coherent mRNAs involved in Rac1 activation includingRac1. Among the DDX3 regulon,Prkacaencodes the catalytic subunit of PKA, a potential activator of Rac1 in neurons. DDX3-modulated PKAcα and Rac1 expression tunes the strength of PKA–Rac1 signaling and thereby contributes to neurite outgrowth and dendritic spine formation. Inhibition of DDX3 activity or expression in neonatal mice impaired dendritic outgrowth and spine formation of hippocampal neurons, echoing neuronal deficits underling DDX3 mutation-associated ID. Finally, we provide evidence that DDX3 activates local protein synthesis through a 5′ UTR-dependent mechanism in neurons. The novel DDX3 regulon may conduct a spatial and temporal control of Rac1 signaling to regulate neurite development.SIGNIFICANCE STATEMENTDDX3Xmutations are linked to intellectual disability (ID). We provide first evidence that DDX3 is required for neurite outgrowth and dendritic spine formationin vitroandin vivo. We identified a DDX3 regulon constituting functionally cohesive mRNAs involved in Rac1 signaling, which contributes to DDX3-modulated neurite development. Inhibition or ablation of DDX3in vivoshortened neurite lengths and impaired dendritic spine formation in hippocampal neurons, reflecting the prevalence of ID-associatedDDX3Xmutations in the helicase domain. Mechanistically, DDX3 activates local protein synthesis of mRNAs sharing similar 5′ UTR structures and therefore controls Rac1 signaling strength in neurites.
Patterns of Comorbidity Among Girls With ADHD: A Meta-analysis
Authors: Tung Irene , Li James J. , Meza Jocelyn I. , Jezior Kristen L. , Kianmahd Jessica S.V. , Hentschel Patrick G. , O’Neil Paul M. , Lee Steve S. 
Published: September 2016

CONTEXT:
Although children with attention-deficit/hyperactivity disorder (ADHD) are at elevated risk for comorbid psychopathology, the clinical correlates of ADHD in girls are far less understood relative to boys, despite ADHD being one of the most common childhood disorders in girls.

OBJECTIVE:
To meta-analytically summarize rates of comorbid internalizing (anxiety, depression) and externalizing (oppositional defiant disorder [ODD], conduct disorder [CD]) psychopathology among girls with and without ADHD.

DATA SOURCES:
Literature searches (PubMed, Google Scholar) identified published studies examining comorbid psychopathology in girls with and without ADHD.

STUDY SELECTION:
Eighteen studies (1997 participants) met inclusion criteria and had sufficient data for the meta-analysis.

DATA EXTRACTION:
Odds ratios for each comorbid disorder were calculated from available data. Demographic (eg, age, race/ethnicity) and study characteristics (eg, referral source, diagnostic method) were also coded.

RESULTS:
Compared with girls without ADHD, girls with ADHD were significantly more likely to meet Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for each comorbid disorder assessed. Relative odds were higher for externalizing (ODD: 5.6×; CD: 9.4×) relative to internalizing disorders (anxiety: 3.2×; depression: 4.2×). Meta-regression revealed larger effect sizes of ADHD on anxiety for studies using multiple diagnostic methods, featuring younger children, and including clinic-referred (versus community-referred) girls; the effect of ADHD on ODD varied based on diagnostic informant.

LIMITATIONS:
Findings were derived from cross-sectional studies, precluding causal inferences.

CONCLUSIONS:
Girls with ADHD frequently exhibit comorbid externalizing and internalizing disorders. We discuss future research priorities and consider intervention implications for ADHD and comorbid psychopathology in girls.
Observación de la calidad de las políticas de movilidad ciclistas desde la participación. Un estudio comparado de Madrid y Sevilla
Authors: Lorenzi Fernández Elisabeth , Acero Carmen 
Published: September 2016

Presentamos resultados y reflexión sobre un estudio que aborda procesos de participación ciudadana en la implementación de los sistemas de movilidad ciclista y su interacción con factores que influyen en la variación de la ciclabilidad, comparando dos áreas metropolitanas españolas (Madrid y Sevilla) en el período 1990-2014. Esta investigación puede ser agrupada en torno a dos aspectos fundamentales que se distinguen y solapan a lo largo de la misma. Por una parte se pretende llevar a cabo un estudio longitudinal y comparativo de los procesos de implementación versados en la movilidad sostenible en las ciudades de Madrid y Sevilla, viendo, del mismo modo, cuáles han sido las mutuas afecciones entre: movimientos probici, políticas públicas, medio ambiente y configuraciones sociales. Nuestro proyecto aborda estas cuestiones poniendo especial foco empírico en el discurso y las prácticas de las instituciones políticas y de los movimientos sociales para analizar su interacción y su impacto en la ciclabilidad de las ciudades de Madrid y Sevilla. A nivel metodológico nuestra investigación ha recogido discursos a través entrevistas en profundidad, observación participante y talleres de devolución y auto diagnóstico. Entendemos que la posibilidad que las metodologías participativas brindan a la hora de exponer y tratar en común los diferentes puntos de vista, inducen a un mayor acercamiento a las múltiples caras que la realidad tiene, logrando, a su vez, una mayor adecuación entre teoría y realidad dada.
Efficient Mixer in Baking “Galamai” Process by Using Camera Sensor
Authors: Kurnia Rahmadi 
Published: September 2016

One of Indonesian traditional food, expecially in Minangkabau called galamai was baked with inefficient and complicated manner. At least 4 or 5 person were needed to mix 30 kg galamai batter for 6 hours during baking process. This research solved those problems. The aim of this work was to displace a human labor with an automatic machine to make it more efficient. The basic idea of this reseach is to desain an automatic mixer by using camera sensor for controling the speed of DC machine. This mixer was worked base on the fact galamai batter characteristics that its color and viscosity will change during cooking process. Discoloration in galamai batter will be captured by camera sensor as a data input. Images data of the color of galamai batter will be converted in grayscale images. The intensity of gray scale image became an input for FIS (Fuzzy Inference System) which controled the speed of machine. The speed of motor will increase when the grayscale color of galamai batter is low. The system could controlled turning speed of motor automatically with acuration of speed value is more than 96.4% and synchronized in variation of galamai batter volume.
Application of Gold Nanoseeds in Surface- Enhanced Raman Spectroscopy for Detection of Urea
Authors: Abdullah Nur Adliha 
Published: September 2016

<p>This paper reports a study to detect urea by a homemade surface-enhanced Raman Spectroscopy (SERS) sensor using gold- nanoseeds (AuNS). The nanoseeds were prepared by the first of two steps of the seed-mediated technique where the sizes of the nanoseeds were controlled through the heat treatment periods. It was demonstrated that gold- nanoseeds (AuNS) with the averages sizes of 15-20 nm can be utilized to enhance the Raman peaks intensities of urea. The enhancement intensities of the Raman peaks are linear with the urea concentrations where the lowest urea concentration that was detected using AuNS from this study is 0.0901 g/L. </p>
Charge Carriers Motion in P3HT:Capped ZnO Nanoparticles Blend Films; Impact of Capping Agents
Authors: Bahtiar Ayi 
Published: September 2016

<p class="TTPAbstract">Blend of conjugated polymer poly(3-hexylthiophene) or P3HT and Zinc Oxide nanoparticles (ZnO-NP) has been intensively used as active material for high performance hybrid solar cells. However, agglomeration of ZnO-NP hinders efficient charge carrier<span lang="IN">s</span> transfer both from P3HT to ZnO-NP and <span lang="IN">their </span>transport within ZnO-NP which cause to low performance of solar cells. Capping of ZnO-NP is currently applied to avoid this agglomeration effect. In this study, we used three different capping agents to cap ZnO-NP, namely small semiconducting molecules squaraine, 2-naphthalene and insulating polymer polyvinylpyrrolidone. We <span lang="IN">conducted</span> temperature dependence of photoinduced infrared absorption spectroscopy to study charge carriers motion in the P3HT:capped ZnO nanoparticles blend films. The measurement was carried out with light irradiation of 532 nm and temperature ranging from 78 to 300 K. The spectra were analyzed by a bimolecular carrier recombination method with Arrhenius activation energy. Two parallel charge carrier recombination processes are observed, namely polarons recombination along polymer chain (intra-chain) and inter-chain polarons recombination in the P3HT-chains. At low temperatures, polarons recombine along polymer chains (intra-chain) with activation energy between 19-23 eV for all samples. However, the inter-chain polaron motion is influenced by capping agents as shown by a variation in its activation energy ranging from 28 to 58 eV.</p>
Synthesis and Characterization of Fibrous Bimetallic CuPt Nanoparticles
Authors: Rahmi Elvy 
Published: September 2016

<p>This paper reports a facile methode for the synthesis of fibrous bimetallic CuPt Nanoparticles (CuPt NPs) using the liquid phase deposition methods deposited directly on an indium-tin oxide (ITO) substrate. The electron microscopy analysis result shows that CuPt NPs, constructed by networked-nanorod of diameter ca. 3.5 nm and length approximately 5.5 to 6.5 nm, exhibits a quasi spherical morphology and fibrous structure with diameter approximately 196±98 nm. The differences of individual element miscibility and the effect of lattice-mismatch between Pt and Cu is the key factor for the formation of fibrous structure. XPS analysis indicated that the fibrous bimetallic CuPt NPs feature metallic properties with highly reactive surface. This may increase the charge-transfer reactions in catalytic, electrochemistry and sensors application.</p><p> </p>
Comparison of Remotely Sensed Wind Data over Sulawesi and Maluku Islands Sea Areas
Authors: Mahmuddin Faisal 
Published: September 2016

<p class="TTPKeywords"><span>In order to obtain accurate prediction of ocean wind energy, long term data are needed. However, one data sources might not able to provide long duration data. Therefore, the data need to be combined with other sources of data. However, before combining the data, it is important to compare and validate them to confirm their accuracy. In the present study, wind speed data collected by QuikScat and SSM/I (SSMIS) missions are compared and analyzed. QuikScat data were collected by a satellite with the same name, while Special Sensor Microwave Imager (SSM/I) and Special Sensor Microwave Imager Sounder (SSMIS) data are processed and offered by Remote Sensing System (RSS). SSM/I (SSMIS) are passive microwave radiometers carried onboard Defense Meteorological Satellite Program (DMSP). For the comparison, 5 (five) arbitrary positions over Sulawesi and Maluku islands sea areas are chosen for the analyses. For the evaluation purposes, beside time series of daily data from several chosen positions in research location, several statistical parameters are also computed and compared such as mean, standard deviation, root mean square (RMS), correlation coefficient. </span></p>
Application Of Trend Analysis Method For Emergency Planningin Npp Accident
Authors: M.U. Pande 
Published: September 2016

<p>A decision for emergency response should be taken based on existing nuclear preparedness assessment. However, lessons learned from the Fukushima accident revealed that emergency response personals had difficulties in estimating time duration needed for the emergency actions. For that case, it is needed an alternative way to determine the time required for a response to be implemented. The objective of this paper is to applicate the trend analysis method for an emergency planning in NPP accident, especially to estimate time duration of countermeasures such as sheltering, evacuation, and relocation. Estimation was done based on consequences and dose data of PWR-1000 MWe severe accident which was simulated for West Bangka site. Dose and consequence estimations were calculated using Pc-cosyma software, and trend analysis application was performed using statistical software. The result of simulation are: iodine tablets are to be distributed to residents in the area within radius of 20-30 km; sheltering countermeasure is needed within the radius of 20-30 km for 12 weeks; evacuation is subjected for the area of 20 km from reactor for duration of 12 weeks; relocation is subjected to radius of 10 km for 2.5 years. The trend analysis can be used for supporting the decision making, especially for emergency planning. The advantage of this method is that it can provide quicker result than past methods. Besides, uncertainties can be reduced by using accurate input data and selection of suitable computation model.</p>
Application Of 99m Tc Radioisotope In Diagnostic Procedures And Internal Radiation Dose Estimation
Authors: Hidayati Nur Rahmah 
Published: September 2016

At about 70% of nuclear medicine procedures have utilized <sup>99m</sup>Tc in their clinical practices.This has lead <sup>99m</sup>Tc becoming the most convenient radioisotope in nuclear medicine diagnostic. To estimate the internal radiation dose due to the administration of <sup>99m</sup>Tc to the patients, only few documents from International Commission of Radiation Protection (ICRP) have been available. However, the calculation usually has applied Caucasian data in Standard Reference Man as a model. The objective of this study was to review the application of <sup>99m</sup>Tc in Indonesia and to compare the internal dose estimation for <sup>99m</sup>Tc procedures by using Organ Level Internal Dose Assessment/ EXponential Modeling (OLINDA/EXM) software. The result of calculation was compared between Adult Caucasian model and Asian Reference Man. The result shows that <sup>99m</sup>Tc has been well applied and developed for diagnostic procedures in Nuclear Medicine Department. Moreover, in most diagnostic procedures using <sup>99m</sup>Tc in Indonesia, adult patients will receive effective dose about 1-15% higher than adult patient in foreign countries which apply the Caucasian model. Hence, to estimate the similar stochastic risk from the same procedure, the maximum value in recommended administered dose should be avoided and need to be evaluated.
Probabilistic Analysis On Levelized Unit Electricity Cost (Luec) Calculation Of Small Medium Reactor Nuclear Power Plant (Smr Npp) In Indonesia
Authors: Anti Nury 
Published: September 2016

<p class="NoSpacing1">SMR NPP is an alternative to overcome the dependency to diesel power plant especially in outside Java Bali system. Economic analysis is a crucial thing that should be done prior to any investment decision on the SMR NPP project and generally done by calculation of Levelized Unit Electricity Cost (LUEC). NPP projects, include SMR, are vulnerable to a number of uncertainty variables. The goal of this study was to perform economic analysis of SMR NPP project with capacity 2 x 100 MWe in Indonesia by incorporating an amount of uncertainty variables, namely the probabilistic approach. The research method is calculating LUEC with deterministic approach followed by the probabilistic approach. Probabilistic approach is done by simulating the effect of uncertainty variable on LUEC using Monte Carlo simulation technique. The results show that the deterministic approach with a discount rate of 10% obtained LUEC at 12.87 cents US$/kWh. Whereas the probabilistic approach obtained LUEC of 13.10 plus minus 1.43 cents USD/kWh at a discount rate of 10% and amounted to 8.11 plus minus 0.88 cents USD/kWh at a discount rate of 5%. calculation in deterministic approach was 12.87 cents USD/ kWh. While LUEC as the results of uncertainty variables simulation on probabilistic approach were 13.10 ± 1.43 cents USD/ kWh on discount rate 10% and 8.11 ± 0.88 cents USD/kWh on discount rate 5%. Occurrence probability of LUEC is less than 13 cents USD/kWh (benchmark value) was about 100% on discount rate of 5% and 50% on discount rate of 10%.<a href="file:///C:/Users/Mohamad%20Mostafa/Desktop/Knowledge%20E/In%20Press%20Conferences/ICoNETS-2015/Source-Manuscripts/19_L04-Nuryanti_p128-135.docx#_msocom_1">[P1]</a> </p><div><hr align="left" size="1" width="33%" /><div><div><p> <a href="file:///C:/Users/Mohamad%20Mostafa/Desktop/Knowledge%20E/In%20Press%20Conferences/ICoNETS-2015/Source-Manuscripts/19_L04-Nuryanti_p128-135.docx#_msoanchor_1">[P1]</a>Revised sentence</p></div></div></div>
Budaya Kerja Melayu dalam Mengembangkan Wirausaha Mahasiswa di Perguruan Tinggi Kota Palembang
Authors: Junaidi Heri 
Published: September 2016

Budaya melayu dan nilai nilai agama berada dalam substansi materi kuliah wirausaha. Beberapa sifat dasar budaya melayu optimis dalam hidup dan kehidupan serta toleran, mengambil positif dari budaya orang lain, berpegang pada agama dan adat, sopan santun, ramah, demokratis, mengutamakan diplomasi dari pada kekerasan. Strategi pembelajaran belum memberikan motivasi secara komprehensif karena lebih mendominasi model ceramah. Secara khsusus mahasiswa menerima materi kuliah dan memiliki kesadaran bahwa budaya Melayu termunculkan di setiap upacara. Namun demikian mereka belum siap berlatih berwirausaha dalam kuliah. Malay cultural and religious values are in substance entrepreneurial course material. Some basic nature of Malay cultural is optimistic in life and life and tolerant, to take something positive from the culture of others, adhering to the religion and customs, manners, friendly, democratic, give priority to diplomacy than violence. Learning strategies have not provided a comprehensive motivation because it dominates the discourse models. In particular, students receive course material and have an awareness that the Malay culture appear in every ceremony. However, they have not ready for practicing entrepreneurship in college.