bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preliminary In silico Analysis of Adenylate Kinase 1 (ADK1) of Echinococcus granulosus as a Candidate for Vaccination against Cystic Echinococcosis
Authors: Hashemi Saman , Shams Khakriz Hanieh , Jalali Niroumand Mohammad , Ghasemi Ezatollah , Majidiani Hamidreza 
Published: September 2024

Background:
A neglected zoonosis, Cystic Echinococcosis (CE), is most common in
developing nations worldwide. Vaccination is, therefore, helpful in preventing the disease.

Objective:
Predicting the main biochemical properties of E. granulosus Adenylate Kinase 1 (ADK1)
and its possible B-cell and T-cell-binding epitopes as a valuable candidate for immunization
was the goal of the current study.

Methods:
Predictions were made to determine biochemical, antigenic, structural, and subcellular
characteristics, along with the immunogenic epitopes, using several online servers.

Results:
The extracellular 22 KDa protein had no allergenicity, while it possessed hydrophilicity
(GRAVY: -0.286), stability (instability: 17.48), tolerance to a wide range of temperatures (aliphatic:
93.45), and 17 post-translational modification sites. The secondary structure mostly comprised
helices and random coils and the 3D model was generated using Robetta server (confidence:
0.88). Common B-cell epitopes were discovered by three servers and screened for antigenic, allergenic,
and solubility traits. Moreover, MHC-associated epitopes for mice and humans were predicted
in E. granulosus ADK1 with subsequent screening.

Conclusion:
This work offers a foundation for further investigation on designing an effective vaccination
against CE. Further empirical research study with the examined protein solely or combined
with other antigens is needed.
Population Digital Health: Continuous Health Monitoring and Profiling at Scale
Authors: Hossein Motlagh Naser , Zuniga Agustin , Thi Nguyen Ngoc , Flores Huber , Wang Jiangtao , Tarkoma Sasu , Prosperi Mattia , Helal Sumi , Nurmi Petteri 
Published: September 2024

Abstract
This paper introduces population digital health (PDH)—the use of digital health information sourced from health internet of things (IoT) and wearable devices for population health modeling—as an emerging research domain that offers an integrated approach for continuous monitoring and profiling of diseases and health conditions at multiple spatial resolutions. PDH combines health data sourced from health IoT devices, machine learning, and ubiquitous computing or networking infrastructure to increase the scale, coverage, equity, and cost-effectiveness of population health. This contrasts with the traditional population health approach, which relies on data from structured clinical records (eg, electronic health records) or health surveys. We present the overall PDH approach and highlight its key research challenges, provide solutions to key research challenges, and demonstrate the potential of PDH through three case studies that address (1) data inadequacy, (2) inaccuracy of the health IoT devices’ sensor measurements, and (3) the spatiotemporal sparsity in the available digital health information. Finally, we discuss the conditions, prerequisites, and barriers for adopting PDH drawing on from real-world examples from different geographic regions.
Client Perspectives of Case Stories in Internet-Delivered Cognitive Behavioral Therapy for Public Safety Personnel: Mixed Methods Study
Authors: Price Jill AB , Gregory Julia , McCall Hugh C , Landry Caeleigh A , Beahm Janine D , Hadjistavropoulos Heather D 
Published: September 2024

Background
Internet-delivered cognitive behavioral therapy (ICBT) is an effective and convenient means of offering cognitive behavioral therapy to the general population. To increase access to ICBT among Canadian public safety personnel (PSP)—a group that experiences elevated rates of mental health concerns and barriers to mental health care—a clinical research unit called PSPNET has tailored ICBT to PSP, primarily through offering case stories and PSP-specific examples within an ICBT program. PSPNET’s first and most frequently used ICBT program, called the PSP Wellbeing Course, has been found to reduce symptoms of mental disorders (eg, anxiety, depression, and posttraumatic stress) among PSP. Little research, however, has investigated clients’ perceptions of the case stories in this course.

Objective
This study was designed to expand the literature on the use and evaluation of case stories in ICBT among PSP. Specifically, this study investigated (1) PSP’s perceptions of the case stories using the theoretical model provided by Shaffer and Zikmund-Fisher and (2) PSP feedback on the case stories in the PSP Wellbeing Course.

Methods
This study included 41 clients who completed the PSP Wellbeing Course. Of these, 27 clients completed a bespoke questionnaire called the Stories Questionnaire, 10 of whom also participated in a semistructured interview.

Results
Findings show that perceptions of the case stories in the PSP Wellbeing Course were largely positive and that the case stories were generally successful in achieving the 5 purposes of case stories (ie, informing, comforting, modeling, engaging, and persuading) proposed by Shaffer and Zikmund-Fisher. Client feedback also identified 3 tangible areas for story improvement: characters, content, and delivery. Each area highlights the need for and potential benefits of story development. Not all PSP engaged with the case stories, though, so results must be interpreted with caution.

Conclusions
Overall, this study adds to the growing body of research supporting the use of case stories in internet-delivered interventions among PSP.

Trial Registration
ClinicalTrials.gov NCT04127032; https://www.clinicaltrials.gov/ct2/show/NCT04127032
Comments of the Auditing Standards Committee of the Auditing Section of the American Accounting Association on the PCAOB’s Proposed Auditing Standard—Designing and Performing Substantive Analytical Procedures and Amendments to Other PCAOB Standards
Authors: Barr-Pulliam Dereck , Boland Colleen M. , Dennis Sean A. , Hermanson Dana R. , Keyser John D. , Pyzoha Jonathan S. , Smith Jason L. 
Published: September 2024

SUMMARY
On June 12, 2024, the Public Company Accounting Oversight Board (the Board or PCAOB) issued a request for comment on Proposed Auditing Standard—Designing and Performing Substantive Analytical Procedures and Amendments to Other PCAOB Standards (PCAOB 2024a). This comment letter presents the views of the participating members of the Auditing Standards Committee of the Auditing Section of the American Accounting Association. We applaud the PCAOB for its ongoing commitment to improve audit quality by addressing enhancements to substantive analytical procedures. Based on our committee’s assessment of the proposal, we provide some overall observations, an analysis based on academic research, and perspectives on the proposal’s economic analysis.
Regional variation in low-value musculoskeletal surgery: a nationwide study from the Finnish Care Register
Authors: Ponkilainen Ville , Laurema Anniina , Mattila Ville M , Karjalainen Teemu 
Published: September 2024

Background and purpose: Healthcare systems globally are grappling with resource constraints and rising costs. Concerns have been raised about “low-value” care, which consumes healthcare resources without benefiting patients. We aimed to examine regional differences in common low-value musculoskeletal surgeries in Finland and explore explanatory factors behind the variation.Methods: Using data from the Finnish Care Register for Health Care, surgeries conducted from 2006–2007 compared with 2020–2021 were analyzed across 20 hospital districts. Selected surgeries (acromioplasty, rotator cuff repair, partial meniscectomy, wrist arthroscopy, ankle arthroscopy, and distal radius fracture fixation) were categorized based on NOMESCO procedure codes, and incidence rates in older populations were calculated based on population size derived from Statistics Finland.Results: We found substantial regional disparities in low-value surgeries. The incidence rates were higher in hospitals with high historical incidence rates and smaller population sizes, suggesting that the uptake of evidence is slower in small non-academic hospitals.Conclusion: The incidence of low-value surgery is declining but regional differences remain large. It is unlikely that regional variation in disease incidence explains such large variation in low-value surgery. Instead, local treatment culture seems to be the driving force behind low-value surgery, and the practices seem to be more entrenched in small hospitals.
Certificados digitais:
Authors: Paula Maria Eloiza dos Santos de , Olavo Antônio Vagner Almeida , Reis Luan Kevin Guimarães Dos , Cirino Andréia Lopes 
Published: September 2024

O objetivo deste estudo é analisar os problemas para a oferta de certificação digital no município de Benjamin Constant, Amazonas. Os procedimentos metodológicos são de natureza exploratória e descritiva, com abordagem qualitativa. Para isso, utilizou-se como ferramenta para coleta de dados um roteiro de entrevista semiestruturada, com 12 funcionários de duas empresas de contabilidade localizadas no município de Benjamin Constant, Amazonas. Como resultado do estudo, foram identificados sete problemas relevantes para os participantes, a saber: a falta de compreensão do uso do certificado digital por parte dos clientes, os custos, as documentações necessárias (documentos legíveis), a perda ou roubo, a distância geográfica dos grandes centros urbanos, profissionais qualificados e, por fim, às dificuldades de acesso/navegabilidade da internet na região amazônica. Conclui-se que os desafios enfrentados pelas empresas de contabilidade estão ligados a questões de conhecimento, à necessidade de fortalecer o governo digital, à qualificação profissional, à logística e à infraestrutura tecnológica existente na região do Alto Solimões.
Pengembangan E-Modul pada Metode Discovery Learning dalam Mata Pelajaran PAI Kelas XI SMA Negeri 1 Sutera
Authors: Yozandra Mayang , Darmansyah Darmansyah , Eldarni Eldarni , Anugrah Septriyan 
Published: September 2024

Penelitian pengembangan e-modul pada Metode Discovery Learning dalam Mata Pelajaran Pendidikan Agama Islam Untuk Kelas XI SMA Negeri 1 Sutera dilakukan sebagai upaya dalam proses belajar mengajar yang diterapkan oleh guru dengan menggunakan metode ceramah, Materi banyak yang tidak bisa dijelaskan dengan kata-kata harus dengan gambar, video dan audio menjadi permasalahan yang ditemukan sehingga proses belajar bersifat konvensiaonal. Sehingga perlu adanya pengembangan bahan ajar yang menarik dan mudah diperoleh peserta didik yaitu bahan ajar berbasis teknologi yang mudah diakses dan dapat meningkatkan motivasi peserta didik berupa e-modul. Pengembangan membuat e-modul ini bertujuan untuk menghasilkan produk e-modul yang valid, praktis dan efektif terhadap proses pembelajaran.
Hubungan Antara Lingkungan Sosial Dengan Kenalan Remaja Di Desa Naras 1 Kota Pariaman
Authors: Nila Citra Rosfir , Solfema Solfema 
Published: September 2024

Latar belakang penelitian adalah rendahnya lingkungan sosial yang mengakibatkan kenakalan remaja di desa Naras 1. Dengan ini diduga dengan lantaran berkurangnya perhatian orang tua sehingga mengakibatkan anak remaja dapat terpengaruh oleh lingkungan sosial yang kurang baik. Penelitian bertujuan untuk: mengetahui 1) menggambarkan kondisi/ keadaan lingkungan sosial di desa naras 1 kota pariaman; 2) menggambarkan kenakalan remaja di desa naras 1 kota pariaman; 3) melihat hubungan kondisi lingkungan sosial terhadap kenakalan remaja di desa naras 1 kota pariaman.Penelitian dilakukan dengan pendekatan kuantitatif jenis korelasional yang bertujuan menguji hubungan lingkungan sosial dengan perilaku kenakalan remaja di desa naras 1 kota pariaman. Populasi dalam penelitian ini dilakukan pada orang tua dari remaja, terdapat dalam 1 keluarga ada 2 atau 3 anak remaja pada 1 keluarga, dengan teknik pengambilan sampel adalah area sampling dan diambil sebanyak 63 orang tua remaja. Metode ini pengumpulan angket dengan format daftar pertanyaan sebagai alat pengumpulan data, teknik analisis data menggunakan persentase dan untuk mencari product moment Hasil penelitian membuktikan 1) tingginya pengaruh lingkungan sosial terhadap kenakalan remaja di desa naras 1 kota pariaman dikategorikan tinggi; 2) kenakalan remaja sangat meresahkan bagi orang tua maupun masyarakat sekitar apalagi lingkungan yang bisa dikatakan tidak baik; 3) terdapat hubungan antara lingkungan sosial dengan perilaku kenakalan remaja di desa naras 1 kota pariaman. Diharapkan peneliti berikutnya perubahan dalam meneliti serta variabel baru sehingga memperlengkap dan memperbanyak variabel penelitian.
Pengembangan Alat Pendidikan Untuk Meningkatkan Minat Belajar Peserta Didik
Authors: Samaloisa Mira Santika , Mardiana Ria , Syafithri Selomita , Rahmanisa Silvia 
Published: September 2024

Developing educational tools to increase students' interest in learning is something that is difficult to realize in the world of education. The aim of writing this article is to identify the role of educational tools in stimulating students' interest in learning and provide views on strategies for developing effective educational tools. In this context, educational tools include a variety of resources such as educational software, learning games, textbooks, and other interactive media. Students' learning interest is a key factor in a sustainable learning process and has an impact on academic achievement. The article writing method used involves literature analysis to evaluate the best approach in designing educational tools that motivate and attract students. The findings of this research indicate that attractive educational tools need to consider various factors, including the diversity of students' learning styles, active involvement, connection to the real world, as well as a playful and exploratory approach. The results of this research provide practical guidance for educators, curriculum developers, and educational tool designers to design educational products that are more effective in increasing students' interest in learning. By understanding the importance of motivating and engaging educational tools, it can be hoped that increasing interest in learning will encourage better academic achievement and create a more dynamic and satisfying learning environment for students.
Tranexamic acid stops hyperfibrinolysis in dogs with hemorrhagic shock: a randomized, controlled clinical trial
Authors: Mays Erin Long , Hansen Bernie , Culbreth Laura , Hanel Rita , Majoy Sean , Rozanski Elizabeth , DeLaforcade Armelle 
Published: September 2024

Abstract

OBJECTIVE
To determine the effect of tranexamic acid (TXA) on clot hyperfibrinolysis (HF), defined as excessive clot lysis at 30 minutes (LY30%), with rapid thromboelastography (rTEG) or rTEG samples spiked with tissue plasminogen activator (tPA-stressed rTEG), in dogs with hemorrhagic shock.

METHODS
Prospective blinded clinical trial at 2 teaching hospitals, March 16, 2018, to May 20, 2022. Twenty-five dogs with hemorrhagic shock and HF were treated with standard care plus either TXA (20 mg/kg; TXA group) or saline (SAL group) over 20 minutes followed by an infusion of the same dose over 8 hours. Rapid TEG and tPA-stressed rTEG assays were performed immediately before study drug administration and at 8, 12, and 24 hours afterwards (T0, T8, T12, and T24, respectively).

RESULTS
4 dogs died or were euthanized before the end of the study period due to disease/injury severity. All survivors had normal rTEG LY30% values after T0; the value for 1 nonsurvivor increased at T8. The tPA-stressed LY30% normalized in all TXA (n = 14) and 8 of 11 SAL dogs at T8; TXA dogs had lower median tPA-stressed rTEG LY30% values at T8 and T12 than SAL dogs (P = .001 and .02, respectively). There was no treatment effect on blood product administration or survival, and no adverse effects were attributed to TXA administration.

CONCLUSIONS
Resuscitation with or without TXA reduced HF identified by tPA-stressed rTEG. Hyperfibrinolysis was completely suppressed at the conclusion of the 8-hour TXA infusion.

CLINICAL RELEVANCE
Although TXA treatment stopped HF, there was no effect on survival or transfusion requirements.
Serious surgical complications of canine cryptorchid castration are associated with surgical approach: a case-control study of 202 dogs
Authors: Faulkner Emma B. , Kimmerlein Anne , Morrison JoAnn , Beal Tricia , Kerl Marie , Saito Emi K. 
Published: September 2024

Abstract

OBJECTIVE
The purpose of this study was to compare a cohort of dogs with serious or life-threatening complications following cryptorchid castration to dogs without complications to identify potential contributing factors to the development of these complications.

METHODS
Dogs that had a cryptorchid castration between 2018 and 2022 in 2 hospital networks were retrospectively reviewed in a case-control manner for reported complications. Inclusion criteria for cases and controls consisted of dogs with documented surgical procedures to address a retained testicle within the abdomen and an in-person follow-up visit at least 2 weeks postoperatively. Exclusion criteria consisted of felines, procedures limited to inguinal cryptorchid castrations, if the retained testicle had undergone malignant transformation, and medical records lacking essential patient or procedure information.

RESULTS
202 dogs were included in the study, with 38 dogs with reported complications and 164 controls. The most reported serious complication was trauma to the prostate, followed by gastrointestinal signs and urinary tract trauma. A complication was more likely if a paramedian skin incision was performed (OR, 4.01; 95% CI, 1.45 to 11.1) compared to a parapreputial incision, as well as if a paramedian abdominal incision was performed compared to a ventral midline incision (OR, 3.4; 95% CI, 1.5 to 7.4).

CONCLUSIONS
The most common complication found in this case-control study was prostatic trauma and was likely associated with inadequate exposure based on the incision location.

CLINICAL RELEVANCE
Parapreputial skin incision and ventral midline abdominal incision increase exposure and visualization of organs, decreasing the risk of serious complications associated with cryptorchid castration.
Clinical course and radiographic resolution of pneumonia in dogs treated with a shorter versus longer course of antimicrobials: a randomized, double-masked, placebo-controlled study
Authors: Reineke Erica L. , McClosky Megan E. , Mauro Katie D. , Schlax Adam , McGonigle Kathryn M. , Scavello Heather , Cole Stephen D. , Redding Laurel E. 
Published: September 2024

Abstract

OBJECTIVE
To describe clinical and radiographic outcomes in dogs with uncomplicated pneumonia receiving a shorter (2-week) versus longer (4-week) duration of antimicrobial therapy.

ANIMALS
30 client-owned dogs with radiographic evidence of pneumonia.

METHODS
Dogs were randomly assigned to either a 2-week course of antimicrobials followed by a 2-week course of placebo medication (2-week group) or a 4-week course of antimicrobials (4-week group). All study investigators and owners were masked to the treatment group. Dogs were reevaluated at 12 ± 2 days and again at 28 ± 2 days for a physical examination and thoracic radiography. Standard documentation at visits included owner-reported clinical signs, nurse-acquired history, the clinician’s physical examination, the number of affected lung lobe segments, and the global radiographic severity scores assigned. Outcomes investigated included the persistence of clinical and radiographic signs of pneumonia.

RESULTS
28 dogs (93.3%) experienced complete resolution of clinical signs by the first visit, and no dogs in either group experienced relapse of clinical signs during the study period. Eighteen of 30 dogs (60%) and 25 of 30 dogs (83%) experienced complete resolution of radiographic lesions at the first and second study visits, respectively. The remaining 5 dogs (17%) had either stable (4 dogs) or continued (1 dog) improvement in radiographic lesions.

CLINICAL RELEVANCE
Resolution of clinical and radiographic signs followed similar courses in dogs with uncomplicated pneumonia receiving a 2-week course of antimicrobials compared to a 4-week course. Clinical signs may be more useful for guiding discontinuation of antimicrobial therapy for pneumonia than radiographic signs.
The mBBM equation: a mathematical key to unlocking wave behavior in fluids
Authors: Mahmoud Attia Raghda Attia , Abdelazeem Khater Mostafa Mohamed 
Published: September 2024

Abstract
This research endeavors to analytically and numerically solve the nonlinear modified Benjamin–Bona–Mahony (mBBM) equation, a model of paramount importance in fluid dynamics, particularly for its application in describing unidirectional water waves with small amplitude that are influenced by dispersion and nonlinear effects. The study’s objective is to enhance the understanding of wave propagation in fluids and to establish a clear connection between the mBBM equation and other nonlinear evolution equations. Utilizing the extended auxiliary equation (EAE) and improved Kudryashov (IKud) methods, the research provides analytical solutions, while the extended cubic–B–spline (ECBS) method validates these solutions numerically. The results showcase the accuracy of the EAE and IKud methods in depicting the wave structures governed by the mBBM equation. The significance of this study lies in its potential to advance the application of the mBBM model in real–world scenarios, such as oceanography and coastal engineering. Conclusively, the research affirms the efficacy of the combined analytical and numerical approach in solving the mBBM equation, contributing novel insights into the field of applied mathematics and nonlinear partial differential equations.
Considerable traveling wave solutions of a generalized Hietarinta-type equation
Authors: Mahmud Adnan Ahmad 
Published: September 2024

Abstract
This work effectively utilizes the modified extended tanh− function approach to scientifically deduce semi-analytic traveling wave solutions for the (2+1)-dimensional fourth-order non-linear generalized Hietarinta-type problem, leading to previously unidentified satisfactory solutions. The proposed model has been transformed into a fourth-order non-linear ordinary differential equation via a traveling wave transformation. Some periodic-solitary, original, and oscillating wave solutions to the model under experimentation are acquired in mixed complex trigonometric and logarithmic functions combined with hyperbolic trigonometric functions, and complex rational functions. Assorted solutions have been shown using two- and three-dimensional graphics and suitable arbitrary parameters to demonstrate their physical and dynamic results. Two-dimensional graphs have shown how changes in time formally impact the features and structures of the solution. The free parameters (unrestricted parameters) that keep going in the solutions have a big impact on the dynamic behavior of the solutions. Traveling wave, oscillating, periodic, and breather wave solutions have also been figured out with the help of the operation that gives values to the free parameters.