bluuebunny/crossref_metadata_2025_split huggingface dataset:
Holger Uhlich, Karel (C.A.J.) Kreutz &amp; Stefan Rätzel (2015) A contribution to the taxonomy and phytogeography of Orobanche alba Steph. ex Willd. (Orobanchaceae). Phytotaxa 222 (1): 1–16.
Authors: Uhlich Holger , Kreutz C.A.J. , Rätzel Stefan 
Published: February 2016

The authors present new knowledge on the biology and distribution of the poorly known Orobanche alba f. cuprea (= O. cuprea) and suggest its reclassification as a subspecies. Furthermore, the authors present recent data on biology and distribution of Orobanche alba subsp. xanthostigma. Distribution maps are shown for both taxa. Thymbra capitata and Thymus integer are recorded as new hosts for O. alba subsp. cuprea and Clinopodium vulgare s. l. for O. alba subsp. xanthostigma. Further information on the taxonomic assessment of other infraspecific taxa of O. alba are given as follows: O. alba f. maxima (= O. alba subsp. major) is promoted to the rank of variety based on a discovered earlier valid name; O. alba subsp. alba var. bidentata is rejected as an autonomous taxon and incorporated in the variability of the species.
Surface Arctic Amplification Factors in CMIP5 Models: Land and Oceanic Surfaces and Seasonality
Authors: Laîné Alexandre , Yoshimori Masakazu , Abe-Ouchi Ayako 
Published: February 2016

Abstract
Arctic amplification (AA) is a major characteristic of observed global warming, yet the different mechanisms responsible for it and their quantification are still under investigation. In this study, the roles of different factors contributing to local surface warming are quantified using the radiative kernel method applied at the surface after 100 years of global warming under a representative concentration pathway 4.5 (RCP4.5) scenario simulated by 32 climate models from phase 5 of the Coupled Model Intercomparison Project. The warming factors and their seasonality for land and oceanic surfaces were investigated separately and for different domains within each surface type where mechanisms differ. Common factors contribute to both land and oceanic surface warming: tropospheric-mean atmospheric warming and greenhouse gas increases (mostly through water vapor feedback) for both tropical and Arctic regions, nonbarotropic warming and surface warming sensitivity effects (negative in the tropics, positive in the Arctic), and warming cloud feedback in the Arctic in winter. Some mechanisms differ between land and oceanic surfaces: sensible and latent heat flux in the tropics, albedo feedback peaking at different times of the year in the Arctic due to different mean latitudes, a very large summer energy uptake and winter release by the Arctic Ocean, and a large evaporation enhancement in winter over the Arctic Ocean, whereas the peak occurs in summer over the ice-free Arctic land. The oceanic anomalous energy uptake and release is further studied, suggesting the primary role of seasonal variation of oceanic mixed layer temperature changes.
Sea Surface Height Variability in Drake Passage
Authors: Donohue Kathleen A. , Kennelly Maureen A. , Cutting Amy 
Published: February 2016

AbstractIntercomparisons between altimeter sea surface height (SSH) and open-ocean in situ observations have been limited owing to sparse available datasets. Here, SSH anomaly (SSHA) determined from current and pressure recording inverted echo sounders (CPIES) from the cDrake experiment were compared with an up-to-date AVISO-mapped product. Meandering Antarctic Circumpolar Current (ACC) fronts in the passage interior elevated SSHA variance; south of the Shackleton Fracture Zone and along the northern continental slope, the variance decreased by factors between 6 and 10. In situ analysis focused on the two constituents of SSHA, SSHAref determined from bottom pressure and SSHAbcb calculated from geopotential height referenced to the bottom. The peak variance of both SSHAbcb and SSHAref occurred in the energetic region between the Subantarctic Front and the Polar Front. The contribution of SSHAbcb to total SSHA variance was greater than 40% at all sites and averaged over all sites it was 73%. For most sites, high-frequency (>1/20 cpd) SSHAbcb signals dominated total high-frequency variance. Aliasing of high-frequency signals resulting from 10-day altimeter sampling was assessed. The fraction of aliased energy at frequencies longer than 1/50 cpd for sites at and north of the Shackleton Fracture Zone approached 0.25 and approached 0.50 for southern sites. CPIES and mapped altimeter SSHA agreed well. The mean correlation coefficient was 0.82 and the mean RMS difference was 0.075 m. Correlations between CPIES and AVISO were notably poorer at the northern and southern boundaries. RMS differences increased as a function of CPIES high-frequency SSHA variance because the mapped altimetry product does not resolve these frequencies.
If worst comes to horrible – sealing an iatrogenic coronary perforation with a polytetrafluoroethylene-covered stent in a patient with aspirin intolerance
Authors: Viertel Achim , Andreas Dominik , Grönefeld Gerian 
Published: February 2016

Abstract
This report outlines the long-term outcome after successful sealing of a coronary perforation with a covered stent in a patient with aspirin allergy.
Effect of Prayer on Intensity of Migraine Headache
Authors: Tajadini Haleh , Zangiabadi Nasser , Divsalar Kouros , Safizadeh Hossein , Esmaili Zahra , Rafiei Hossein 
Published: February 2016

Background and Aim. Migraine is a common form of headache that affects patients quality of life negatively. In addition to pharmacologic treatment, there are a variety of nonpharmacologic treatments for migraine headache. In present study, we examined the effect of prayer on intensity of migraine pain. Methods. In a prospective, randomized, controlled trial from October 2013 to June 2014, this study has been conducted in Kerman, Iran. We randomly assigned 92 patients in 2 groups to receive either 40 mg of propranolol twice a day for 2 month (group “A”) or 40 mg of propranolol twice a day for 2 months with prayer (group “B”). At the beginning of study and 3 months after intervention, patients’ pain was measured using the visual analogue scale. Results. At the beginning of study and before intervention, the mean score of pain in patients in groups A and B were 5.7 ± 1.6 and 6.5 ± 1.9, respectively. According to results of independent t test, mean score of pain intensity at the beginning of study were similar between patients in 2 groups ( P > .05). Three month after intervention, mean score of pain intensity decreased in patients in both groups. At this time, the mean scores of pain intensity were 5.4 ± 1.1 and 4.2 ± 2.3 in patients in groups A and B, respectively. This difference between groups was statistically significant ( P < .001). Conclusions. The present study revealed that prayer can be used as a nonpharmacologic pain coping strategy in addition to pharmacologic intervention for this group of patients.
Results From a Patient Experience Study in Pediatric Gastrointestinal Endoscopy
Authors: Jacob Divya Ann , Franklin Linda , Bernstein Bruce , Pall Harpreet 
Published: February 2016

Objective: Gastrointestinal endoscopy in children has become a standard diagnostic and therapeutic modality. The aim of our study was to characterize the most memorable elements of the patient experience from the parent’s and patient’s perspective and determine ways to improve the overall quality of their experience. Methods: Using a structured questionnaire, we conducted 47 phone interviews with families who had recently undergone gastrointestinal endoscopic procedures. Results: Our study showed clear communication and mutual agreement on care decisions contributed to positive experiences. Inadequate communication of information regarding alternatives to the procedure and risk of complications during the informed consent discussion contributed to negative patient experiences. Standardization of postprocedure follow-up and timely communication of pathology findings also had potential for improvement. Conclusion: Our study revealed 2 areas for quality improvement interventions: The need to ensure that alternatives and complications are thoroughly discussed and the need for standardization of postprocedure follow-up.
Urinary chitinase 3-like protein 1 for early diagnosis of acute kidney injury: a prospective cohort study in adult critically ill patients
Authors: De Loor Jorien , Decruyenaere Johan , Demeyere Kristel , Nuytinck Lieve , Hoste Eric AJ , Meyer Evelyne 
Published: February 2016

Abstract
Background
Acute kidney injury (AKI) occurs frequently and adversely affects patient and kidney outcomes, especially when its severity increases from stage 1 to stages 2 or 3. Early interventions may counteract such deterioration, but this requires early detection. Our aim was to evaluate whether the novel renal damage biomarker urinary chitinase 3-like protein 1 (UCHI3L1) can detect AKI stage ≥2 more early than serum creatinine and urine output, using the respective Kidney Disease | Improving Global Outcomes (KDIGO) criteria for definition and classification of AKI, and compare this to urinary neutrophil gelatinase-associated lipocalin (UNGAL).

Methods
This was a translational single-center, prospective cohort study at the 22-bed surgical and 14-bed medical intensive care units (ICU) of Ghent University Hospital. We enrolled 181 severely ill adult patients who did not yet have AKI stage ≥2 based on the KDIGO criteria at time of enrollment. The concentration of creatinine (serum, urine) and CHI3L1 (serum, urine) was measured at least daily, and urine output hourly, in the period from enrollment till ICU discharge with a maximum of 7 ICU-days. The concentration of UNGAL was measured at enrollment. The primary endpoint was the development of AKI stage ≥2 within 12 h after enrollment.

Results
After enrollment, 21 (12 %) patients developed AKI stage ≥2 within the next 7 days, with 6 (3 %) of them reaching this condition within the first 12 h. The enrollment concentration of UCHI3L1 predicted the occurrence of AKI stage ≥2 within the next 12 h with a good AUC-ROC of 0.792 (95 % CI: 0.726–0.849). This performance was similar to that of UNGAL (AUC-ROC of 0.748 (95 % CI: 0.678–0.810)). Also, the samples collected in the 24-h time frame preceding diagnosis of the 1st episode of AKI stage ≥2 had a 2.0 times higher (95 % CI: 1.3–3.1) estimated marginal mean of UCHI3L1 than controls. We further found that increasing UCHI3L1 concentrations were associated with increasing AKI severity.

Conclusions
In this pilot study we found that UCHI3L1 was a good biomarker for prediction of AKI stage ≥2 in adult ICU patients.
Recreating the image of Chan master Huineng: the roles of MOOD and MODALITY
Authors: Yu Hailing , Wu Canzhong 
Published: February 2016

AbstractThe article investigates the roles of MOOD and MODALITY in the recreation of the image of Chan master Huineng in four English translations ofThe Platform Sutraby Wong Mou-lam, (Sutra Spoken by the Sixth Patriarch, Wei Lang, on the High Seat of the Gem of Law(Message from the East), 1930), Heng Yin, (The Sixth Patriarch's Dharma Jewel Platform Sutra, 1977), Thomas Cleary, (The Sutra of Hui-neng, grand master of Zen: with Hui-neng's commentary on the Diamond Sutra, 1998) and Cheng Kuan (The Dharmic Treasure Altar-Sutra of the Sixth Patriarch, 2011). MOOD refers to the mood types of indicative and imperative, and MODALITY covers the semantic space between ‘yes’ and ‘no’. Adopting SysFan, a computational tool for doing systemic and functional analysis, the study investigates the choice of mood types and the values of modality (low, median and high) in each translation. Heng and Cleary favour high-valued modality more than Wong and Cheng though the mood type of declarative is adopted by all. They also use more imperative clauses and indicative clauses with high-valued modality than the latter. Consequently, two types of image are recreated of Huineng: an authoritative and forceful Huineng presented by the two American translators, and a prudent and polite Huineng presented by the two Chinese translators. The investigation shows that the phenomenon cannot be accounted for by the translators’ linguistic competence. Instead, the context of the translation, especially the tenor, should be taken into consideration to interpret these two types of image of Huineng.
IL-36γ is secreted in microparticles and exosomes by lung macrophages in response to bacteria and bacterial components
Authors: Kovach Melissa A , Singer Benjamin H , Newstead Michael W , Zeng Xianying , Moore Thomas A , White Eric S , Kunkel Steven L , Peters-Golden Marc , Standiford Theodore J 
Published: February 2016

Abstract
Interleukin-36 is a family of novel interleukin-1-like proinflammatory cytokines that are highly expressed in epithelial tissues and several myeloid-derived cell types. Like those of classic interleukin-1 cytokines, the secretion mechanisms of interleukin-36 are not well understood. Interleukin-36γ secretion in dermal epithelial cells requires adenosine 5′-triphosphate, which suggests a nonclassical mechanism of secretion. In this study, murine pulmonary macrophages and human alveolar macrophages were treated with recombinant pathogen-associated molecular patterns (intact bacteria: Klebsiella pneumoniae or Streptococcus pneumoniae). Cell lysates were analyzed for messenger ribonucleic acid by quantitative real-time polymerase chain reaction, and conditioned medium was analyzed for interleukin-36γ by enzyme-linked immunosorbent assay, with or without sonication. In addition, conditioned medium was ultracentrifuged at 25,000 g and 100,000 g, to isolate microparticles and exosomes, respectively, and interleukin-36γ protein was assessed in each fraction by Western blot analysis. Interleukin-36γ mRNA was induced in both murine and human lung macrophages by a variety of pathogen-associated molecular patterns, as well as heat-killed and live Klebsiella pneumoniae and Streptococcus pneumoniae, and induction occurred in a myeloid differentiation response gene 88–dependent manner. Secretion of interleukin-36γ protein was enhanced by adenosine 5′-triphosphate. Furthermore, extracellular interleukin-36γ protein detection was markedly enhanced by sonication to disrupt membrane-bound structures. Interleukin-36γ protein was detected by Western blot in microparticles and exosome fractions isolated by ultracentrifugation. Interleukin-36γ was induced and secreted from lung macrophages in response to Gram-negative and -positive bacterial stimulation. The results suggest that interleukin-36γ is secreted in a non-Golgi–dependent manner by lung macrophages in response to Gram-positive and -negative bacterial challenge.
Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice
Authors: Ohba Kenji , Leow Melvin Khee-Shing , Singh Brijesh Kumar , Sinha Rohit Anthony , Lesmana Ronny , Liao Xiao-Hui , Ghosh Sujoy , Refetoff Samuel , Sng Judy Chia Ghee , Yen Paul Michael 
Published: February 2016

Abstract
Clinical symptoms may vary and not necessarily reflect serum thyroid hormone (TH) levels during acute and chronic hyperthyroidism as well as recovery from hyperthyroidism. We thus examined changes in hepatic gene expression and serum TH/TSH levels in adult male mice treated either with a single T3 (20 μg per 100 g body weight) injection (acute T3) or daily injections for 14 days (chronic T3) followed by 10 days of withdrawal. Gene expression arrays from livers harvested at these time points showed that among positively-regulated target genes, 320 were stimulated acutely and 429 chronically by T3. Surprisingly, only 69 of 680 genes (10.1%) were induced during both periods, suggesting desensitization of the majority of acutely stimulated target genes. About 90% of positively regulated target genes returned to baseline expression levels after 10 days of withdrawal; however, 67 of 680 (9.9%) did not return to baseline despite normalization of serum TH/TSH levels. Similar findings also were observed for negatively regulated target genes. Chromatin immunoprecipitation analysis of representative positively regulated target genes suggested that acetylation of H3K9/K14 was associated with acute stimulation, whereas trimethylation of H3K4 was associated with chronic stimulation. In an in vivo model of chronic intrahepatic hyperthyroidism since birth, adult male monocarboxylate transporter-8 knockout mice also demonstrated desensitization of most acutely stimulated target genes that were examined. In summary, we have identified transcriptional desensitization and incomplete recovery of gene expression during chronic hyperthyroidism and recovery. Our findings may be a potential reason for discordance between clinical symptoms and serum TH levels observed in these conditions.
Colloidal Mesoporous Silica Nanoparticles
Authors: Yamamoto Eisuke , Kuroda Kazuyuki 
Published: February 2016

Abstract
Mesoporous silica nanoparticles (MSNs) with colloidal stability have attracted increasing interest because of their important properties, such as high transparency and cell uptake. Colloidal MSNs are comprehensively reviewed from the viewpoints of their preparation, characterization, and applications which include biomedical, catalytic, and optical materials. The following two points have been emphasized. The first point is that this review covers the widest range of introduction and discussion of the preparation and applications of both colloidal and noncolloidal MSNs. The second point is that this account contains a discussion from the viewpoints of both inorganic and colloid chemistries. After the introduction of the historical background of preparation of MSNs, preparative methods of colloidal MSNs and the major factors for the preparation of nanosized and colloidal MSNs are discussed. The methods to control the size, composition, morphology, and pore size of MSNs are also presented. Appropriate methods to obtain MSNs with high colloidal dispersibility are also discussed. Applications of colloidal MSNs are introduced with an emphasis on the colloidal stability. Issues to be addressed for further developments of colloidal MSNs are finally described.
Recent Advances in the Trichomonas vaginalis Field
Authors: Leitsch David 
Published: February 2016

The microaerophilic protist parasiteTrichomonas vaginalisis occurring globally and causes infections in the urogenital tract in humans, a condition termed trichomoniasis. In fact, trichomoniasis is the most prevalent non-viral sexually transmitted disease with more than 250 million people infected every year. Although trichomoniasis is not life threatening in itself, it can be debilitating and increases the risk of adverse pregnancy outcomes, HIV infection, and, possibly, neoplasias in the prostate and the cervix. Apart from its role as a pathogen,T.vaginalisis also a fascinating organism with a surprisingly large genome for a parasite,i.e. larger than 160 Mb, and a physiology adapted to its microaerophilic lifestyle. In particular, the hydrogenosome, a mitochondria-derived organelle that produces hydrogen, has attracted much interest in the last few decades and renderedT.vaginalisa model organism for eukaryotic evolution.This review will give a succinct overview of the major advances in theT.vaginalisfield in the last few years.
Synergistic Approach to Enterprise Management
Authors: Заковоротный  , Zakovorotnyy Vilor , Угнич  , Ugnich Ekaterina , Флек  , Flek Mikhail 
Published: February 2016

The research reveals the peculiarities of synergistic model of enterprise
management in market conditions. The possibilities of synergistic approach
application towards the study of economic systems are shown in the article.
On the basis of theoretical analysis of complex dynamic systems basic rules
are identified which must be taken into consideration while examining the
enterprise as a system in which the processes of self-organization exist.
A generalized dynamic model of an enterprise in market environment is
presented. It is carried out the analysis of the established condition of the
enterprise as a system and the stability of its stationary state.
Reengineering As a Tool of Crisis Management
Authors: Калиматова  , Kalimatova L. 
Published: February 2016

This article discusses reengineering as a tool of crisis management. Reengineering
is analyzed as a fundamental rethinking and radical redesign of business
processes to achieve the key breakthrough in the current performance of the
company, such as costs, product quality, service levels, etc. This approach
creates the preconditions for long-term stable operation of enterprises, greatly
reduces the appearance and development of crisis situations.
Economic Potential of Pumped-Storage Hydroelectric Power Plants
Authors: Быстров  , Bystrov Andrey , Юсим  , Yusim Vyacheslav , Филиппов  , Filippov V. 
Published: February 2016

The article deals with questions of using pumped-storage hydroelectric power
plants in electrical power system. Maneuverable reserve of Russian electrical
power system is exhausted; therefore further development is able only with
the presence of storage plants in the system which will allow getting additional
volume of electricity with existent generative power stations. However, low
return of investment slows down construction of storage plants. PSP exert a
powerful economic effect on system which is undervalued. Therefore for
ensuring a return on investment it is necessary to revise system of economic
relations within industry when using system utilities.
Different Susceptibility of B-Type Natriuretic Peptide (BNP) and BNP Precursor (proBNP) to Cleavage by Neprilysin: The N-Terminal Part Does Matter
Authors: Semenov Alexander G , Katrukha Alexey G 
Published: February 2016

Abstract

BACKGROUND
Protease neprilysin is known to be responsible for the degradation of natriuretic peptides. A recent heart failure (HF) drug, LCZ696 (EntrestoTM), that combines a neprilysin inhibitor and an angiotensin II receptor inhibitor was suggested to augment circulating B-type natriuretic peptide (BNP) concentrations, making the results of BNP measurements diagnostically ambiguous. Because the main form of measured BNP in HF patients is represented by its uncleaved precursor, proBNP, it is important to know the susceptibility of proBNP to cleavage by neprilysin.

METHODS
BNP 1–32 and nonglycosylated and glycosylated forms of proBNP 1–108 were incubated with neprilysin for different time periods. BNP immunoreactivity was analyzed using 2 sandwich immunoassays: one utilizing monoclonal antibody (mAb) KY-BNP-II (epitope 14–21) as capture with mAb 50E1 (epitope 26–32) for detection and a single-epitope sandwich BNP (SES-BNP) immunoassay specific to the epitope 11–17. Mass-spectrometry was applied to determine the sites of BNP cleavage.

RESULTS
In contrast to BNP, both forms of proBNP were resistant to degradation by neprilysin. The SES-BNP assay was much less susceptible to the BNP cleavage by neprilysin compared with the immunoassay utilizing antibodies specific to the region 14–21, comprising the site Arg17-Ile18, known as the site of BNP cleavage by neprilysin.

CONCLUSIONS
These findings suggest that modulation of neprilysin activity by specific inhibitors may not greatly influence the circulating concentrations of immunoreactive BNP, mostly represented in HF by proBNP, which is not susceptible to neprilysin. The different susceptibility of the BNP regions to neprilysin-dependent degradation highlights the importance of the choice of epitopes for reliable BNP immunodetection.