bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival impact of induction chemotherapy in advanced head and neck cancer: A National Cancer Database analysis
Authors: Stokes William A. , Amini Arya , Jones Bernard L. , McDermott Jessica D. , Raben David , Ghosh Debashis , Goddard Julie A. , Bowles Daniel W. , Karam Sana D. 
Published: March 2017

ABSTRACTBackgroundAdding induction chemotherapy to concurrent chemotherapy and radiotherapy (RT) has generally not improved the overall survival (OS) in randomized trials of patients with head and neck cancer. This failure may stem from inadequate power or inappropriate patient selection, prompting this National Cancer Data Base analysis.Methods8031 patients with T4 or N2b to N3 disease undergoing RT and chemotherapy were divided into induction chemotherapy and concurrent chemotherapy cohorts. Multivariate analysis was used to explore the association of treatment with survival and to identify predictors of radiation dose.ResultsOn multivariate analysis incorporating sociodemographic and clinical variables, survival of the induction chemotherapy cohort was not significantly different from that of the concurrent cohort (hazard ratio [HR], 0.96; 95% confidence interval [CI], 0.88–1.05; p = .35), nor on subgroup analyses of advanced disease. Multivariate analysis demonstrated increased odds of receiving <66 Gy among the patients in the induction chemotherapy cohort (p < .01).ConclusionInduction chemotherapy subjects experienced no survival advantage over concurrent chemotherapy subjects but were more likely to receive lower RT doses. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1113–1121, 2017
Effect of daily fraction size on laryngoesophageal dysfunction after chemoradiation for squamous cell carcinomas of the larynx and hypopharynx
Authors: Chen Allen M. , Hsu Sophia , Meshman Jessica , Chin Robert , Beron Philip , Abemayor Elliot , St. John Maie 
Published: March 2017

ABSTRACTBackgroundThe purpose of this study was to determine the effect of fraction size on laryngoesophageal dysfunction among patients treated by chemoradiotherapy for laryngeal and hypopharyngeal cancer.MethodsForty patients underwent chemoradiotherapy for stage III/IV squamous cell carcinomas of the larynx and hypopharynx. Median radiation dose was 70 Gy (range, 69.3–70.4 Gy) with daily fractionation ranging from 2 Gy to 2.2 Gy.ResultsWhen comparing 2 Gy versus >2 Gy daily fractionation, there was no difference in 2‐year overall survival (71% vs 72%; p = .68), locoregional control (79% vs 77%; p = .43), or laryngectomy‐free survival (60% vs 61%; p = .72). Use of 2 Gy versus >2 Gy fractionation improved laryngoesophageal dysfunction‐free survival (2‐year estimates, 49% vs 27%; p = .07). Patient‐reported voice and swallowing were improved with the former.ConclusionAs the importance of a functional larynx becomes recognized as an endpoint for patients treated by voice preservation, the results of our study help refine treatment guidelines. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1322–1326, 2017
Drip Irrigation with Sewage Effluent Increased Salt Accumulation in Soil, Depressed Sap Flow, and Increased Yield of Tomato
Authors: Li Yanfeng , Li Jiusheng , Wen Jiangli 
Published: March 2017

AbstractSewage application is a cost‐effective method for meeting the challenge of irrigation in water‐short regions. However, there is concern about the accumulation of salt from sewage effluent in soil. Experiments were conducted for 3 years in a greenhouse to investigate the effects of water quality on salt accumulation in soil and on sap flow for drip‐irrigated tomato. The types of irrigation water used in the experiments included secondary sewage effluent, groundwater, and blended water that was obtained by mixing the secondary sewage effluent and the groundwater in equal volumes. The results demonstrated that soil bulk electrical conductivity (ECb) increased with irrigation rates, and sewage application produced a more rapid increase than did blended water and groundwater treatments. Irrigation throughout the growing season could produce a 21–44% increase in salt content from its initial values to values at harvest, and salt accumulation occurred mainly at the 30–45 cm depth of soil. Sewage irrigation was likely to decrease sap flow but increased tomato yield and improved fruit quality parameters excluding ascorbic acid compared with groundwater irrigation. These results suggest that secondary sewage application using drip irrigation increases salt accumulation in the root zone, and depresses crop transpiration to some extent, but does not have a negative influence on tomato yield and fruit quality. Copyright © 2017 John Wiley & Sons, Ltd.
Insulin Resistance and the IGF-I-Cortical Bone Relationship in Children Ages 9 to 13 Years
Authors: Kindler Joseph M , Pollock Norman K , Laing Emma M , Oshri Assaf , Jenkins Nathan T , Isales Carlos M , Hamrick Mark W , Ding Ke-Hong , Hausman Dorothy B , McCabe George P , Martin Berdine R , Hill Gallant Kathleen M , Warden Stuart J , Weaver Connie M , Peacock Munro , Lewis Richard D 
Published: March 2017

ABSTRACT

IGF-I is a pivotal hormone in pediatric musculoskeletal development. Although recent data suggest that the role of IGF-I in total body lean mass and total body bone mass accrual may be compromised in children with insulin resistance, cortical bone geometric outcomes have not been studied in this context. Therefore, we explored the influence of insulin resistance on the relationship between IGF-I and cortical bone in children. A secondary aim was to examine the influence of insulin resistance on the lean mass-dependent relationship between IGF-I and cortical bone. Children were otherwise healthy, early adolescent black and white boys and girls (ages 9 to 13 years) and were classified as having high (n = 147) or normal (n = 168) insulin resistance based on the homeostasis model assessment of insulin resistance (HOMA-IR). Cortical bone at the tibia diaphysis (66% site) and total body fat-free soft tissue mass (FFST) were measured by peripheral quantitative computed tomography (pQCT) and dual-energy X-ray absorptiometry (DXA), respectively. IGF-I, insulin, and glucose were measured in fasting sera and HOMA-IR was calculated. Children with high HOMA-IR had greater unadjusted IGF-I (p &lt; 0.001). HOMA-IR was a negative predictor of cortical bone mineral content, cortical bone area (Ct.Ar), and polar strength strain index (pSSI; all p ≤ 0.01) after adjusting for race, sex, age, maturation, fat mass, and FFST. IGF-I was a positive predictor of most musculoskeletal endpoints (all p &lt; 0.05) after adjusting for race, sex, age, and maturation. However, these relationships were moderated by HOMA-IR (pInteraction &lt; 0.05). FFST positively correlated with most cortical bone outcomes (all p &lt; 0.05). Path analyses demonstrated a positive relationship between IGF-I and Ct.Ar via FFST in the total cohort (βIndirect Effect = 0.321, p &lt; 0.001). However, this relationship was moderated in the children with high (βIndirect Effect = 0.200, p &lt; 0.001) versus normal (βIndirect Effect = 0.408, p &lt; 0.001) HOMA-IR. These data implicate insulin resistance as a potential suppressor of IGF-I-dependent cortical bone development, though prospective studies are needed. © 2017 American Society for Bone and Mineral Research.
Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia Cells Through Bcr/Abl‐JAK/STAT Signaling Pathways
Authors: Cai Hong , Qin Xiaosong , Yang Chunhui 
Published: March 2017

ABSTRACTThis study evaluates the anticancer effects of dehydrocostus lactone, a plant‐derived sesquiterpene lactone, on human chronic myeloid leukemia cells. Dehydrocostus lactone significantly inhibits cell proliferation by inducing cells to undergo cell cycle arrest, apoptosis, and differentiation. Dehydrocostus lactone suppresses the expression of cyclin B1, cyclin A, cyclin E, cyclin‐dependent kinase 2 (CDK2), and cyclin‐dependent kinase 1 (CDK1) and increases p21 expression, resulting in S‐G2/M phase arrest in K562 cells. Dehydrocostus lactone also induces apoptosis by increasing the generation of reactive oxygen species (ROS), disruption of mitochondrial membrane potential (MMP), and modulating the protein levels of Bcl‐2 family members. We also found that dehydrocostus lactone significantly inhibits the phosphorylation expression of Bcr/Abl, STAT5, JAK2, and STAT3 and downstream molecules including p‐CrkL, Mcl‐1, Bcl‐XL, and Bcl‐2 proteins in K562 cells. At a low concentration, dehydrocostus lactone significantly increased CD11b and CD14 expression on the surface of K562 cells, and induced cells to differentiate into monocytes or mature macrophages. Taken together, this study provides new insight into the molecular mechanisms of dehydrocostus lactone actions that may contribute to the chemoprevention of chronic myeloid leukemia. J. Cell. Biochem. 118: 3381–3390, 2017. © 2017 Wiley Periodicals, Inc.
Impact of executive function on efficacy obtaining resources following intimate partner violence
Authors: Lee Michelle Seulki , DePrince Anne P. 
Published: March 2017

AbstractFollowing intimate partner violence (IPV), women risk losing resources needed to meet their basic needs, such as food and housing. To identify potential points of community intervention, the current study examined the role of executive function (EF) in women's efficacy to obtain resources following a police‐reported physical IPV incident. Participants were 199 women from diverse, urban, and largely lower‐income backgrounds. As predicted, greater physical abuse was associated with worse EF performance and worse EF was associated with less efficacy in obtaining resources 1 year later. Greater physical abuse was indirectly related to less efficacy in obtaining resources via EF, even when controlling for income. Results provide information regarding EF as a potential link in the relationship between IPV and obtaining resources among women of lower‐income backgrounds. In the context of limited resources, preparing community service professionals to use EF‐focused interventions (e.g., to structure tasks, repeat instructions) may support women's efforts to access resources.
Novel carboxylated graphene oxide‐CuS‐Ag nanocomposite glass coating for organic degradation under solar light
Authors: Yu Shuyan , Webster Richard D , Zhou Yan , Yan Xiaoli 
Published: March 2017

AbstractBACKGROUDRecently, semiconductor‐mediated heterogeneous photocatalysis has gained recognition as an effective treatment method for the removal of emerging organic contaminants (EOCs) from wastewater. The advantages of such technology include higher reaction rates for pollutant removal, complete mineralisation of the contaminants into harmless substances, e.g. water and carbon dioxide. Here, this study synthesized a hybrid multifunctional nanocomposite (GO‐COOH‐CuS‐Ag) via a facile method by integrating semiconductor copper sulfide (CuS) nanoflakes, carboxylic acid functionalised graphene oxide (GO‐COOH) sheets, and silver (Ag) nanoparticles, with the aim to enhance their EOCs photodegradation and antibacterial applications under solar light irradiation.RESULTSThe crystal phase, optical properties and morphology of the obtained composite were characterized using various characterization methods. The as‐synthesized GO‐COOH‐CuS‐Ag nanocomposites were transformed and applied on glass via a glass coating method aimed at facilitating their practical applications in photodegradation of emerging organic contaminants (EOCs) and disinfection for water treatment under solar light irradiation. The glass coatings had excellent photodegradation and antibacterial performance with good stability and repeatability. It was also found that synergistic reactions existed among CuS, Ag and GO‐COOH, and the mechanisms of charge transfer and photo‐disinfection were systematically investigated.CONCLUSIONThe results clearly demonstrate its high performance potential in photodegradation and photo‐disinfection processes with the advantage of simplifying recovery and reuse in comparison with powdered forms, and reducing problems including the agglomeration of powdered particles that may cause blockages. © 2017 Society of Chemical Industry
Clinical performance of high‐resolution late gadolinium enhancement imaging with compressed sensing
Authors: Basha Tamer A. , Akçakaya Mehmet , Liew Charlene , Tsao Connie W. , Delling Francesca N. , Addae Gifty , Ngo Long , Manning Warren J. , Nezafat Reza 
Published: March 2017

PurposeTo evaluate diagnostic image quality of 3D late gadolinium enhancement (LGE) with high isotropic spatial resolution (∼1.4 mm3) images reconstructed from randomly undersampled k‐space using LOw‐dimensional‐structure Self‐learning and Thresholding (LOST).Materials and MethodsWe prospectively enrolled 270 patients (181 men; 55 ± 14 years) referred for myocardial viability assessment. 3D LGE with isotropic spatial resolution of 1.4 ± 0.1 mm3 was acquired at 1.5T using a LOST acceleration rate of 3 to 5. In a subset of 121 patients, 3D LGE or phase‐sensitive LGE were acquired with parallel imaging with an acceleration rate of 2 for comparison. Two readers evaluated image quality using a scale of 1 (poor) to 4 (excellent) and assessed for scar presence. The McNemar test statistic was used to compare the proportion of detected scar between the two sequences. We assessed the association between image quality and characteristics (age, gender, torso dimension, weight, heart rate), using generalized linear models.ResultsOverall, LGE detection proportions for 3D LGE with LOST were similar between readers 1 and 2 (16.30% vs. 18.15%). For image quality, readers gave 85.9% and 80.0%, respectively, for images categorized as good or excellent. Overall proportion of scar presence was not statistically different from conventional 3D LGE (28% vs. 33% [P = 0.17] for reader 1 and 26% vs. 31% [P = 0.37] for reader 2). Increasing subject heart rate was associated with lower image quality (estimated slope = –0.009 (P = 0.001)).ConclusionHigh‐resolution 3D LGE with LOST yields good to excellent image quality in >80% of patients and identifies patients with LV scar at the same rate as conventional 3D LGE.Level of Evidence: 2Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2017;46:1829–1838.
Numerical model of static hysteresis taking into account temperature
Authors: Sixdenier Fabien , Scorretti Riccardo 
Published: March 2017

AbstractSome soft magnetic materials are strongly dependent of the temperature, because of their low Curie temperature. To be able to predict their behaviour in electrical devices, hysteresis models able to take into account the temperature are needed. The vector play static hysteresis model is an interesting hysteresis model that can be modified to be able to take into account the thermal behaviour. In this paper, the temperature is taken into account in this last model through its parameters. The variations of some parameters with temperature are mainly issued from numerical interpolation and specific assumptions. Simulation results are compared to measurements and discussed.
Endophytic fungi harbored in the root of Sophora tonkinensis Gapnep: Diversity and biocontrol potential against phytopathogens
Authors: Yao Yu Qun , Lan Fang , Qiao Yun Ming , Wei Ji Guang , Huang Rong Shao , Li Liang Bo 
Published: March 2017

AbstractThis work, for the first time, investigated the diversity of endophytic fungi harbored in the xylem and phloem of the root of Sophora tonkinensis Gapnep from three geographic localities with emphasis on the influence of the tissue type and geographic locality on endophytic fungal communities and their potential as biocontrol agents against phytopathogens of Panax notoginseng. A total of 655 fungal strains representing 47 taxa were isolated. Forty‐two taxa (89.4%) were identified but not five taxa (10.6%) according to morphology and molecular phylogenetics. Out of identifiable taxa, the majority of endophyte taxa were Ascomycota (76.6%), followed by Basidiomycota (8.5%) and Zygomycota (4.3%). The alpha‐diversity indices indicated that the species diversity of endophytic fungal community harbored in the root of S. tonkinensis was very high. The colonization and species diversity of endophytic fungal communities were significantly influenced by the geographic locality but not tissue type. The geographic locality and tissue type had great effects on the species composition of endophytic fungal communities. Forty‐seven respective strains were challenged by three fungal phytopathogens of P. notoginseng and six strains exhibited significant inhibitory activity. It was noteworthy that endophytic Rhexocercosporidium sp. and F. solani strongly inhibited pathogenic F. solani and other fungal phytopathogens of P. notoginseng.
Synthesis and characterization of block poly(ester‐ether‐urethane)s from bacterial poly(3‐hydroxybutyrate) oligomers
Authors: Debuissy Thibaud , Pollet Eric , Avérous Luc 
Published: March 2017

ABSTRACTTelechelic hydroxylated poly(3‐hydroxybutyrate) (PHB‐diol) oligomers have been successfully synthesized in 90–95% yield from high molar mass PHB by tin‐catalyzed alcoholysis with different diols (mainly 1,4‐butanediol) in diglyme. The PHB‐diol oligomers structure was studied by nuclear magnetic resonance, Fourier transformed infrared spectroscopy MALDI‐ToF MS, and size exclusion chromatography, whereas their crystalline structures, thermal properties and thermal stability were analyzed by wide angle X‐ray scattering, DSC, and thermogravimetric analyses. The kinetic of the alcoholysis was studied and the influence of (i) the catalyst amount, (ii) the diol amount, (iii) the reaction temperature, and (iv) the diol chain length on the molar mass was discussed. The influence of the PHB‐diol molar mass on the thermal stability, the thermal properties and optical properties was investigated. Then, tin‐catalyzed poly(ester‐ether‐urethane)s (PEEU) of Mn = 15,000–20,000 g/mol were synthesized in 1,2‐dichloroethane from PHB‐diol oligomers (Pester) with modified 4,4'‐MDI and different polyether‐diols (Pether) (PEG‐2000, PEG‐4000, and PPG‐PEG‐PPG). The influence of the PHB‐diol chain length, the Pether/Pester ratio, the polyether segment nature and the PEG chain length on the thermal properties and crystalline structures of PEEUs was particularly discussed. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 1949–1961
Analysis of matrix‐assisted laser desorption/ionization quadrupole time‐of‐flight collision‐induced dissociation spectra of simple precursor ions and isobaric oligosaccharide ion mixtures based on product ion intensities and pattern recognition
Authors: Jovanović Marko , Tyldesley‐Worster Richard 
Published: March 2017

RationaleQualitative analysis of glycomic tandem mass spectrometry (MS/MS) data based on m/z values of product ions alone is widely used, and often sufficient for analysis of single analytes. However, most complex glycomic mixtures contain multiple isobaric oligosaccharides, in which case this approach is often limited. Here we show how ion intensity information can be used in order to enhance MS/MS data analysis, and extract both qualitative and semiquantitative information from complex glycomic MS/MS datasets.MethodsA matrix‐assisted laser desorption/ionization quadrupole time‐of‐flight (MALDI QTOF) mass spectrometer was used in this study. We compared the intensities of product ions within a single product ion series, determined by their length, across the whole glycomic MS/MS dataset. In order to detect discernable patterns, the intensity data was normalized to the intensity of each product ion within the series. In most cases, normalized data yielded easily discernable patterns, relevant either for analysis of specific glycomic structure types, or mechanistic MS studies.ResultsWe used our approach on a glycomic sample consisting of human milk oligosaccharides. The approach yielded useful results for both qualitative and semiquantitative analyses. All normalizations performed were not equally rich in information and the information content of generated tables was not possible to predict. These analyses were shown to be independent of instrument manufacturer.ConclusionsOur approach enabled more detailed qualitative analysis of MS/MS spectra of precursor ions containing isobaric oligosaccharide structures. While limited semiquantitative information could be extracted from the raw data as well, the accuracy of this method should be significantly enhanced when standard calibration mixtures can be prepared. Copyright © 2017 John Wiley & Sons, Ltd.
Evaluation and comparison of open source software suites for data mining and knowledge discovery
Authors: Altalhi Abdulrahman H. , Luna J. M. , Vallejo M. A. , Ventura S. 
Published: March 2017

The growing interest in the extraction of useful knowledge from data with the aim of being beneficial for the data owner is giving rise to multiple data mining tools. Research community is specially aware of the importance of open source data mining software to ensure and ease the dissemination of novel data mining algorithms. The availability of these tools at no cost, and also the chance of better understanding of the approaches by examining their source code, provides the research community with an opportunity to tune and improve the algorithms. Documentation, updating, variety of algorithms, extensibility, and interoperability among others can be major issues to motivate users for opting for a specific open source data mining tool. The aim of this paper is to evaluate 19 open source data mining tools and to provide the research community with an extensive study based on a wide set of features that any tool should satisfy. The evaluation is carried out by following two methodologies. The first one is based on scores provided by experts to produce a subjective judgment of each tool. The second procedure performs an objective analysis about which features are satisfied by each tool. The ultimate aim of this work is to provide the research community with an extensive study on different features included in any data mining tool, either from a subjective and an objective point of view. Results reveal that RapidMiner, Konstanz Information Miner, and Waikato Environment for Knowledge Analysis are the tools that include higher percentage of these features. WIREs Data Mining Knowl Discov 2017, 7:e1204. doi: 10.1002/widm.1204This article is categorized under:

Application Areas > Data Mining Software Tools
Technologies > Computer Architectures for Data Mining
MODELING NO-TILL ADOPTION BY CORN AND SOYBEAN PRODUCERS: INSIGHTS INTO SUSTAINED ADOPTION
Authors: WADE TARA , CLAASSEN ROGER 
Published: March 2017

AbstractNo-till acreage has increased in recent years, but many farmers alternate no-till with other tillage practices, limiting public and private benefits from sustained no-till adoption. Revealed preference data are used in an ordered logit regression analysis to determine the effect of soil characteristics, climate, regions, farm characteristics, and producer demographics on producers’ choices to use continuous tillage, alternate no-till systems with tillage systems, or continuously use no-till. The model provides insight into the characteristics and conditions that are conducive to each tillage regime. The attributes found to significantly affect continuous no-till use are erodibility classification, drainage, farm size, and climate.