bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Analysis of Patient Safety Incident Reports Associated with Electronic Health Record Interoperability
Authors: Adams Katharine , Howe Jessica , Fong Allan , Puthumana Joseph , Kellogg Kathryn , Gaunt Michael , Ratwani Raj 
Published: June 2017

SummaryBackground: With the widespread use of electronic health records (EHRs) for many clinical tasks, interoperability with other health information technology (health IT) is critical for the effective delivery of care. While it is generally recognized that poor interoperability negatively impacts patient care, little is known about the specific patient safety implications. Understanding the patient safety implications will help prioritize interoperability efforts around architectures and standards.Objectives: Our objectives were to (1) identify patient safety incident reports that reflect EHR interoperability challenges with other health IT, and (2) perform a detailed analysis of these reports to understand the health IT systems involved, the clinical care processes impacted, whether the incident occurred within or between provider organizations, and the reported severity of the patient safety events.Methods: From a database of 1.735 million patient safety event (PSE) reports spanning multiple provider organizations, 2625 reports that were indicated as being health IT related by the event reporter were reviewed to identify EHR interoperability related reports. Through a rigorous coding process 209 EHR interoperability related events were identified and coded.Results: The majority of EHR interoperability PSE reports involved interfacing with pharmacy systems (i.e. medication related), followed by laboratory, and radiology. Most of the interoperability challenges in these clinical areas were associated with the EHR receiving information from other health IT systems as opposed to the EHR sending information to other systems. The majority of EHR interoperability challenges were within a provider organization and while many of the safety events reached the patient, only a few resulted in patient harm.Conclusions: Interoperability efforts should prioritize systems in pharmacy, laboratory, and radiology. Providers should recognize the need to improve EHRs interfacing with other health IT systems within their own organization.Citation: Adams KT, Howe JL, Fong A, Puthumana JS, Kellogg KM, Gaunt M, Ratwani RM. An analysis of patient safety incident reports associated with electronic health record interoperability. Appl Clin Inform 2017; 8: 593–602 https://doi.org/10.4338/ACI-2017-01-RA-0014
Reanimating Lost Landscapes: Bringing Visualisation to Aboriginal History
Authors: Read Peter 
Published: June 2017

In Public History Review volume 11, Peter Osborne called for the methodologies of environmental history to be brought more securely and more imaginatively into public history. Environmental history by its own definition, he argued, encompassed Indigenous, ethnic and Anglo-Celtic histories, and heritages natural and built, material and intangible. I believe too that we public historians need to Incorporate changing landscapes and topographies as a vital element in understanding why communities and their built heritages constantly transfigure. Sometimes a single geographic factor such as the northern Gulf Stream can go far to explain the spectacular rise of a small island like Great Britain to world power. Equally we can help to explain the precipitous decline of towns like Bourke by degradation and siltation in the Darling River.
This paper uses the case study of the Narrabeen town camp to explore the potential of digital visual technologies in Aboriginal History.
E-democracy: meer demos door digitale revolutie?
Authors: Metze Tamara , Cuijpers Colette 
Published: June 2017

E-democracy: empowerment of the demos through a digital revolution?
E-democracy incorporates digital tools, the internet and social media to enhance democracy. There are many of these tools available to improve governmental responsiveness, transparency, and accountability, but also to support the inclusiveness, representativeness and influence of citizens’ participation. Examples are online petitions, apps for neighborhood watches, wikiplanning and social media monitoring. Web 3.0, which is more interactive and less location specific, enables governments to take a more personalized approach. It also allows for participation across administrative and geographical boundaries. In this symposium two contributions address the question of the influence of e-democracy on the democratization of governmental decision-making, information and service delivery, and of citizens’ participation.
Het rechte pad
Authors: Doekhie Jennifer , Dirkzwager Anja , Nieuwbeerta Paul 
Published: June 2017

To desist or not to desist? A qualitative study of long-term prisoners in the Netherlands and their plans for life after prison
This study focuses on a sample of 28 male long-term prisoners in the Netherlands who are about to return to society. The aims of the study are to examine their future expectations regarding criminal behavior and to explore how social and individual factors, such as employment, family support and agency, relate to these expectations. This is important because such expectations may affect their actual (criminal) behavior after release. Pre-release semi-structured in-depth interviews included questions about their future expectations, social ties, and sense of agency. Prisoners expecting to quit with criminal activities had both close social ties to society and scored high on individual factors.
Nog niet effectief genoeg: het huisverbod in perspectief
Authors: de Vaan Katrien 
Published: June 2017

Not effective enough just yet! Perspectives on the Dutch temporary restraining order
In 2009 the Dutch temporary restraining order Act came into being. The order is a much used instrument in the fight against domestic violence. However, it’s effectivity has yet to be proven beyond doubt. There are signs the order can be effective, but it is unknown what influences this effect: which choices in its implementation, which characteristics of violence and those involved, which characteristics of the care that is provided.This article claims that the temporary restraining order can be more effective if we collect more data on what it is that makes it effective, and use this data to mirror the order against other instruments that are available in the fight against domestic violence. In that way, we can choose the instrument that best suits the situation, instead of picking the temporary restraining order simply because it is most readily available. This means the following is necessary: 1) more knowledge about the types of situations in which the order can be most effective; 2) more knowledge about the effects of choices that are being made in the implementation of the instrument; 3) an overview of all available instruments for intervening in situations of serious and immediate threat of domestic violence and the effects that can be reached with those instruments; and 4) a better use of available knowledge about the effects of care and assistance to victims and perpetrators of domestic violence to improve the trajectories that accompany temporary restraining orders. This will enable a more balanced choice between these orders and other interventions and will improve the effects of the orders and the care and assistance that accompanies them.
Osteopathic medical considerations of reflex sympathetic dystrophy
Authors: Nelson Kenneth E. 
Published: June 2017

Abstract
Review of current medical literature reveals little understanding of the physiology underlying the complex signs and symptoms that accompany reflex sympathetic dystrophy (RSD). The author surveyed the osteopathic medical literature and found a significant body of research documenting the physiology of somatic dysfunction. The manifestations of upper thoracic somatic dysfunction are strikingly similar to those of RSD and may offer insight into its heretofore unexplained physiology of this disorder.
Bicycle helmet laws: A current perspective
Authors: Borgialli Dominic A. 
Published: June 2017

Abstract
Bicycle-related head trauma is a significant source of death, disability, and healthcare costs in the United States. Bicycle helmets are effective safety devices that can reduce most of this burden on society. Bicycle helmet laws and education programs are effective ways to increase helmet use rates. Osteopathic physicians can play a prominent role in bicycle-related injury prevention by actively supporting and participating in helmet legislation, research, and community-based education. This article provides a current summary of state bicycle helmet laws and highlights research that supports the effectiveness and necessity of these laws. The recent trend in safety standards for bicycle helmets is included to give a comprehensive view of bicycle helmet law in the United States.
Superior vena cava syndrome caused by a benign retrosternal multinodular goiter
Authors: Promisloff Robert A. , Pervall-Phillips Gina P. 
Published: June 2017

Abstract
Retrosternal thyroid accounts for a significant percentage of anterior mediastinal masses, but has been described very rarely as the cause of superior vena cava (SVC) syndrome. Most cases of SVC syndrome occur as a complication of malignancy. The authors report the case of a patient with few respiratory symptoms, mild upper airway obstruction, and SVC syndrome caused by a benign retrosternal multinodular goiter.
Spontaneous expulsion of an intravesical bullet
Authors: Didomenico David , Guinan Patrick , Sharifi Roohollah 
Published: June 2017

Abstract
Gunshot wounds of the pelvis are not uncommon. Penetrating injuries of the bladder are usually documented by means of a cystogram. The patient reported here was shot with a small caliber bullet. No extravasation was demonstrated. The authors caution that not all penetrating injuries to the bladder will demonstrate extravasation on a properly performed cystogram.
Excision of urethral diverticulum calculi in a pregnant patient on an outpatient basis
Authors: Wittich Arthur C. 
Published: June 2017

Abstract
Although the incidence of urethral diverticula in women of reproductive age ranges from 0.6% to 6%, urethral diverticulum calculi are rarely reported. This report describes excision and outpatient management of urethral diverticulum calculi in a symptomatic pregnant patient. The etiology, diagnosis, and recommended therapy of urethral diverticulum calculi are discussed. Historically, surgical therapy has been considered appropriate; however, recent technologic advancements-including ultrasound and lithotripsy-may change this widely accepted method of treatment.
Surface rupturing earthquakes repeated in the 300 years along the ISTL active fault system, central Japan
Authors: Katsube Aya , Kondo Hisao , Kurosawa Hideki 
Published: June 2017

AbstractSurface rupturing earthquakes produced by intraplate active faults generally have long recurrence intervals of a few thousands to tens of thousands of years. We here report the first evidence for an extremely short recurrence interval of 300 years for surface rupturing earthquakes on an intraplate system in Japan. The Kamishiro fault of the Itoigawa‐Shizuoka Tectonic Line (ISTL) active fault system generated a Mw 6.2 earthquake in 2014. A paleoseismic trench excavation across the 2014 surface rupture showed the evidence for the 2014 event and two prior paleoearthquakes. The slip of the penultimate earthquake was similar to that of 2014 earthquake, and its timing was constrained to be after A.D. 1645. Judging from the timing, the damaged area, and the amount of slip, the penultimate earthquake most probably corresponds to a historical earthquake in A.D. 1714. The recurrence interval of the two most recent earthquakes is thus extremely short compared with intervals on other active faults known globally. Furthermore, the slip repetition during the last three earthquakes is in accordance with the time‐predictable recurrence model rather than the characteristic earthquake model. In addition, the spatial extent of the 2014 surface rupture accords with the distribution of a serpentinite block, suggesting that the relatively low coefficient of friction may account for the unusually frequent earthquakes. These findings would affect long‐term forecast of earthquake probability and seismic hazard assessment on active faults.
Connecting Antarctic sea ice to deep‐ocean circulation in modern and glacial climate simulations
Authors: Marzocchi Alice , Jansen Malte F. 
Published: June 2017

AbstractAntarctic sea‐ice formation plays a key role in shaping the abyssal overturning circulation and stratification in all ocean basins, by driving surface buoyancy loss through the associated brine rejection. Changes in Antarctic sea ice have therefore been suggested as drivers of major glacial‐interglacial ocean circulation rearrangements. Here, the relationship between Antarctic sea ice, buoyancy loss, deep‐ocean stratification, and overturning circulation is investigated in Last Glacial Maximum and preindustrial simulations from the Paleoclimate Modelling Intercomparison Project (PMIP). The simulations show substantial intermodel differences in their representation of the glacial deep‐ocean state and circulation, which is often at odds with the geological evidence. We argue that these apparent inconsistencies can largely be attributed to differing (and likely insufficient) Antarctic sea‐ice formation. Discrepancies can be further amplified by short integration times. Deep‐ocean equilibration and sea‐ice representation should, therefore, be carefully evaluated in the forthcoming PMIP4 simulations.
Relation between Human Serum Albumin Structure and Fluorescence Decay Parameters of Tryptophan Residue 214
Authors: Jankeje Kristina , Amiri Megdouda , Albani Jihad René 
Published: June 2017

AbstractThe purpose of this article is to study the relation between fluorescence decay parameters of tryptophan residue in human serum albumin (HSA) and the protein structure. HSA contains a single tryptophan residue, and thus, there will be no ambiguity on the data obtained.HSA comprises a single polypeptide of 585 amino acid residues with only one tryptophan residue. Tryptophan fluorescence is very sensitive to the local environment. Global form and structure of HSA are pH dependent. Thus, in this article, behavioral changes and fluorescence characteristics of tryptophan within HSA were studied at different pHs (2–12) and in the denatured state in the presence of guanidine hydrochloride solution.In an environment with a low pH (at pHs 2 and 3), tryptophan emits at a maximum of 330 nm. The peak position shifts to 340 nm at higher pH. Peak position values indicate no protein denaturation but a structural modification. The loss of the tertiary protein structure (complete denaturation) induces a shift in tryptophan fluorescence to 352 nm.At all pHs, tryptophan residue emits with three lifetimes. Lifetime measurements at different pHs along the emission wavelengths allowed us to differentiate the different forms of HSA.In the denatured state, tryptophan emission occurs also with three lifetimes. However, values and contributions of these lifetimes to the global emission decay differ between the native and denatured states.We have considered that fluorescence emission occurs from tryptophan substructures, each substructure is characterized by one lifetime along with its pre‐exponential. Populations of the substructures, characterized by the pre‐exponential values of the fluorescence lifetimes, are dependent on the microenvironment of the fluorophore and on the global protein structure.
The Interaction of Metal Compounds with Protein Targets: New Tools in Medicinal Chemistry and Chemical Biology
Authors: Miller Jessica J. , Gomes Luiza M. F. , Storr Tim , Casini Angela 
Published: June 2017

Abstract
In cells and organisms, metal complexes can be specifically designed to interact with biomolecules and accordingly alter important biological processes. These interactions have been widely explored for targeting specific biological functions and diseases. In fact, several studies have demonstrated that inorganic chemistry offers significant diversity and versatility for the preparation of highly potent protein modulators (e.g., inhibitors). Moreover, both coordination and organometallic complexes featuring favorable chemico‐physical properties (e.g., luminescence) have proven to be well suited to image proteins and peptides in living cells by various methods. An inherent advantage of metal complexes is the accessibility of multiple oxidation states, and overall charge and geometries, which makes them attractive from the point of view of chemical design. However, these properties can become a disadvantage if not controlled and fine‐tuned in the biological application. In this review, we generally discuss the use of metal compounds, targeting proteins and/or peptides, in medicinal chemistry and chemical biology, and then focus on representative recent examples and applications. Furthermore, we highlight future challenges and attractive perspectives in the field, which may stimulate research and define new frontiers in bioinorganic chemistry.
Divergent Reactivity of (Diacyloxyiodo)arenes under Palladium Catalysis: Controlled Allylic C−H Acyloxylation and Vinylic Arylation
Authors: Yue Qiang , Yang Tingting , Yang Yaocheng , Zhang Chuancheng , Zhang Qian , Li Dong 
Published: June 2017

AbstractThe divergent reactivity of (diacyloxyiodo)arenes in the palladium‐catalyzed allylic C−H acyloxylation and vinylic arylation reactions of various alkenes has been established. These reactions proceed under simple, mild, and ligand‐free conditions to give C−H acyloxylation and vinylic arylation products in moderate to good yields with high regioselectivities. This reaction can employ a broad scope of substrates and has good functional group compatibility. This method will greatly broaden the applications for (diacyloxyiodo)arenes in organic synthesis.
Highly Active Ruthenium Supported on Magnetically Recyclable Chitosan‐Based Nanocatalyst for Nitroarenes Reduction
Authors: Liew Kin Hong , Rocha Mariana , Pereira Clara , Pires Ana L. , Pereira André M. , Yarmo Mohd Ambar , Juan Joon Ching , Yusop Rahimi M. , Peixoto Andreia F. , Freire Cristina 
Published: June 2017

AbstractA Ru supported on a magnetically separable chitosan‐based nanomaterial (Mn@CS@Ru) was prepared by wet impregnation based on ionic gelation using sodium tripolyphosphate as a cross‐linking agent. The ionic gelation of chitosan leads to a supporting matrix to promote the embedding of manganese(II) ferrite and Ru nanoparticles (NPs) by electrostatic interactions. The effects of the formulation and method parameters on the fabrication process were investigated, and the resulting as‐prepared Mn@CS@Ru nanocatalyst was characterized. The catalytic activity of the Mn@CS@Ru nanomaterial was evaluated in the reduction of 4‐nitrophenol (4‐NP) and 4‐nitroaniline (4‐NA) in the presence of sodium borohydride as a reducing agent at room temperature. The turnover frequency values in the reduction of 4‐NP and 4‐NA were 273.9 and 336.5 min−1, respectively, which were attributed to the very small size of the hybrid nanomaterial (32.0±2.8 nm with 3.9±0.1 nm Ru NPs) that provided a large surface‐area‐to‐volume ratio for the chemical reaction. Furthermore, the hybrid nanocatalyst was recovered easily by magnetic separation after the catalytic reaction and could be reused in at least 10 cycles without a loss of catalytic activity, which confirms its high stability. The present route is a new approach to synthesize highly active magnetic heterogeneous catalysts for the reduction of nitroarenes based on metallic NPs with easy accessibility, excellent activity, and convenient recovery.
Alternating Copolymer of Double Four Ring Silicate and Dimethyl Silicone Monomer–PSS‐1
Authors: Smet Sam , Vandenbrande Steven , Verlooy Pieter , Kerkhofs Stef , Breynaert Eric , Kirschhock Christine E. A. , Martineau‐Corcos Charlotte , Taulelle Francis , Van Speybroeck Veronique , Martens Johan A. 
Published: June 2017

AbstractA new copolymer consisting of double four ring (D4R) silicate units linked by dimethylsilicone monomer referred to as polyoligosiloxysilicone number one (PSS‐1) was synthesized. The D4R building unit is provided by hexamethyleneimine cyclosilicate hydrate crystals, which were dehydrated and reacted with dichlorodimethylsilane. The local structure of D4R silicate units and dimethyl silicone monomers was revealed by multidimensional solid‐state NMR, FTIR and modeling. On average, D4R silicate units have 6.8 silicone linkages. Evidence for preferential unidirectional growth and chain ordering within the PSS‐1 copolymer was provided by STEM and TEM. The structure of PSS‐1 copolymer consists of twisted columns of D4R silicate units with or without cross‐linking. Both models are consistent with the spectroscopic, microscopic and physical properties. PSS‐1 chains are predicted to be mechanically strong compared to silicones such as PDMS, yet more flexible than rigid silica materials such as zeolites.
Inhibition of angiogenesis impairs bone healing in an in vivo murine rapid resynostosis model
Authors: Hyzy Sharon L. , Kajan Illya , Wilson D. Scott , Lawrence Kelsey A. , Mason Devon , Williams Joseph K. , Olivares‐Navarrete Rene , Cohen David J. , Schwartz Zvi , Boyan Barbara D. 
Published: June 2017

AbstractBiologics can improve bone formation, but may diffuse away from sites of therapeutic need. We developed a click‐chemistry hydrogel that rapidly polymerizes in situ to control delivery of biologics during post‐suturectomy resynostosis in 21‐day‐old male mice. Here, we used this model to determine the role of angiogenesis in post‐suturectomy resynostosis and examine whether controlled release of angiogenesis inhibitors could delay bone regeneration. Hydrogels [DB‐co‐PEG/poly (TEGDMA)‐co‐(N3‐TEGDMA)] were produced containing anti‐angiogenic compounds [anti‐VEGFA‐antibody or hypoxia inducible factor 1α‐inhibitor topotecan]. Bioactivity in vitro was assessed by tube length and branching points of endothelial cells in hydrogel‐conditioned media. In vivo effects were examined 14 day post‐suturectomy, based on the temporal analysis of angiogenic mRNAs during resynostosis following posterior frontal suture removal. MicroCT was used to quantify angiogenesis in contrast‐agent‐perfused blood vessels and bone defect size in defects receiving hydrogel, anti‐VEGFA/hydrogel, or topotecan/hydrogel. Shorter endothelial tube length and less branching were seen in inhibitor‐conditioned media (topotecan > AbVEGFA). In vivo, both compounds inhibited angiogenesis compared with hydrogel‐only. Anti‐VEGFA/hydrogel reduced resynostosis compared with empty defects, but topotecan/hydrogel blocked bone regeneration. We demonstrate that anti‐angiogenic compounds can be incorporated into a spontaneously polymerizing hydrogel and remain active over 14 days in vitro and in vivo. Moreover, bone formation can be delayed by inhibiting neovascularization, suggesting possible use as a therapeutic to control resynostosis following suturectomies and potential applications in other conditions where rapid osteogenesis is not desired. © 2017 Wiley Periodicals Inc. J Biomed Mater Res Part A: 105A: 2742–2749, 2017.