bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between pre-pregnancy obesity and screening results of depression for all trimesters of pregnancy, postpartum and 1 year after birth: a cohort study
Authors: Salehi-Pourmehr Hanieh , Mohammad-Alizadeh Sakineh , Jafarilar-Agdam Nayyer , Rafiee Somayyeh , Farshbaf-Khalili Azizeh 
Published: February 2017

Abstract

Objective:
To determine the relationship between pre-pregnancy obesity and screening results of gestational and post-delivery depression in women referred to the health centers of Tabriz, Iran.

Methods:
In this cohort study, 62 and 245 pregnant women with class 2–3 obesity [body mass index (BMI)≥35 kg/m2] and normal-weight (BMI 18.5–24.9 kg/m2) were enrolled, respectively, in the first trimester of pregnancy from December 2012 to January 2016. For matching of groups, nulliparous and multiparous mothers aged 18–35 years were selected with the ratio of 1:4 in obese and normal BMI groups from the same recruitment center and to controlling the confounder factors, inclusion criteria were considered. The Edinburgh Postnatal Depression Scale (EPDS) was completed in five time points, the first, second, third trimester of pregnancy, 6–8 weeks and 12 months after delivery. Independent t-test, Mann-Whitney, chi-square, Fisher’s exact tests and multivariate logistic and linear regression adjusted for confounders were used. P<0.05 was considered as statistically significant.

Results:
Based on the EPDS, 12.7% of normal weight women in first, 13.5% in second, 10.2% in third trimester of pregnancy, 7.8% in 6–8 weeks of postpartum and 10.6% in 1 year after delivery screened positive for depression. This proportion was greater in class 2–3 obese women (32.3%, 33.3%, 28.8% in trimesters of pregnancy and 35.4%, 19.4% in postpartum period, respectively) (P<0.05). The results of multivariate logistic regression adjusted for confounding factors showed that the risk of depression in the first trimester of pregnancy for class 2–3 obesity was 3.25-fold greater than normal weight group [adjusted odds ratio (aOR) 3.25, 95% confidence interval (CI) 1.68–6.28]. This risk was 3.29-fold in the second (aOR 3.29, 95% CI 1.67–6.47), 4-folds in the third trimester (aOR 4.003, 95% CI 1.84–8.70 for third), 7.5-fold in the 6–8 weeks of postpartum (aOR 7.46, 95% CI 3.30–16.89) and 1.83-fold (aOR 7.46, 95% CI 3.30–16.89) for 1 year after birth.

Conclusions:
Pre-pregnancy obesity was associated with probability of gestational and post-delivery depression. Therefore, training and planning to conduct required interventions to resolve obesity seem be helpful in this regard.
The Transcendence and Visibility of the Father in the Gospel of John
Authors: Filtvedt Ole Jakob 
Published: February 2017

Abstract:This article examines five statements in John related to the visibility of the Father (1,18; 5,37; 6,46; 12,45; 14,7–11). Some of these seem to affirm that the Father can be seen, while others seem to deny it. The article argues that John ultimately holds that God can be seen, that the passages that seem to deny this only deny the possibility of unmediated access to the Father, apart from Jesus, and that John has developed three ways of securing God’s transcendence, despite his visibility: (i) the vision of God is only available through Jesus; (ii) the vision of God is climaxed precisely where God seems to be absent, namely in Jesus’ crucifixion; and (iii) the vision of God in Jesus’ crucifixion runs counter to human expectations, and is therefore only recognizable with hindsight. Thus, John is able to affirm both God’s visibility and transcendence.
Stabilization of Fine-Grained Soils Against Desiccation Cracking Using Sustainable Materials
Authors: Jayanthi P. N. V. , Kuntikana G. , Singh D. N. 
Published: February 2017

AbstractDesiccation cracking is a phenomenon commonly associated with the fine-grained soils, which initiates at their surface and subsequently propagates deeper inside their matrix. Hence, for safe and durable infrastructure development, stabilization of such soils becomes important. In order to stabilize these soils, cement, chemicals, and fibers have been employed by earlier researchers. However, in recent times, the ill effects of these stabilizers on the ecosystem have been realized, and hence their replacement with sustainable materials that are mostly industrial by-products is becoming necessary. This philosophy would not only conserve natural resources, but would also result in a “marriage” between “two suitable” materials to create a “synergy” within the ecosystem. With this in view, the ground granulated blast furnace slag (GGBS), a by-product from the iron and steel plants, was activated by red mud (RM), a by-product from alumina manufacturing units, with an objective to establish its utility in stabilizing the fine-grained soils against desiccation cracking. To achieve this, the parameter crack intensity factor (CIF), which has been employed by earlier researchers to quantify cracking characteristics of the (virgin) soil mass, has been employed for the soils amended with GGBS and RM. Subsequently, the CIF has been correlated with the soil specific parameters (viz., cation exchange capacity and tensile strength) and the environmental conditions (viz., humidity and temperature), represented by the evaporation rate of the soil mass. Based on these extensive investigations, it has been demonstrated that such correlations would be very useful for selection of the right combination of the soil and sustainable material(s) to achieve a stabilized system of the fine-grained soil. It has been put forth through this study that the by-products chosen exhibit high potential to stabilize the fine-grained soils, which also resulted in alteration of their micro-structure and strength post stabilization. Furthermore, studies have been carried out to establish the effect of addition of industrial by-products to virgin soils, mainly in terms of their micro-structure, which in turn controls their strength.
Identification of Genes inSaccharomyces cerevisiaethat Are Haploinsufficient for Overcoming Amino Acid Starvation
Authors: Bae Nancy S , Seberg Andrew P , Carroll Leslie P , Swanson Mark J 
Published: February 2017

AbstractThe yeast Saccharomyces cerevisiae responds to amino acid deprivation by activating a pathway conserved in eukaryotes to overcome the starvation stress. We have screened the entire yeast heterozygous deletion collection to identify strains haploinsufficient for growth in the presence of sulfometuron methyl, which causes starvation for isoleucine and valine. We have discovered that cells devoid of MET15 are sensitive to sulfometuron methyl, and loss of heterozygosity at the MET15 locus can complicate screening the heterozygous deletion collection. We identified 138 cases of loss of heterozygosity in this screen. After eliminating the issues of the MET15 loss of heterozygosity, strains isolated from the collection were retested on sulfometuron methyl. To determine the general effect of the mutations for a starvation response, SMM-sensitive strains were tested for the ability to grow in the presence of canavanine, which induces arginine starvation, and strains that were MET15 were also tested for growth in the presence of ethionine, which causes methionine starvation. Many of the genes identified in our study were not previously identified as starvation-responsive genes, including a number of essential genes that are not easily screened in a systematic way. The genes identified span a broad range of biological functions, including many involved in some level of gene expression. Several unnamed proteins have also been identified, giving a clue as to possible functions of the encoded proteins.
Second-GenerationDrosophilaChemical Tags: Sensitivity, Versatility, and Speed
Authors: Sutcliffe Ben , Ng Julian , Auer Thomas O , Pasche Mathias , Benton Richard , Jefferis Gregory S X E , Cachero Sebastian 
Published: February 2017

AbstractThick tissue specimens present major challenges for labeling cells and subcellular structures in a rapid and reliable manner. Sutcliffe et al. present...Labeling and visualizing cells and subcellular structures within thick tissues, whole organs, and even intact animals is key to studying biological processes. This is particularly true for studies of neural circuits where neurons form submicron synapses but have arbors that may span millimeters in length. Traditionally, labeling is achieved by immunofluorescence; however, diffusion of antibody molecules (&gt;100 kDa) is slow and often results in uneven labeling with very poor penetration into the center of thick specimens; these limitations can be partially addressed by extending staining protocols to over a week (Drosophila brain) and months (mice). Recently, we developed an alternative approach using genetically encoded chemical tags CLIP, SNAP, Halo, and TMP for tissue labeling; this resulted in &gt;100-fold increase in labeling speed in both mice and Drosophila, at the expense of a considerable drop in absolute sensitivity when compared to optimized immunofluorescence staining. We now present a second generation of UAS- and LexA-responsive CLIPf, SNAPf, and Halo chemical labeling reagents for flies. These multimerized tags, with translational enhancers, display up to 64-fold increase in sensitivity over first-generation reagents. In addition, we developed a suite of conditional reporters (4xSNAPf tag and CLIPf-SNAPf-Halo2) that are activated by the DNA recombinase Bxb1. Our new reporters can be used with weak and strong GAL4 and LexA drivers and enable stochastic, intersectional, and multicolor Brainbow labeling. These improvements in sensitivity and experimental versatility, while still retaining the substantial speed advantage that is a signature of chemical labeling, should significantly increase the scope of this technology.
Efficacy and Safety of Nonoperative Treatment for Acute Appendicitis: A Meta-analysis
Authors: Georgiou Roxani , Eaton Simon , Stanton Michael P. , Pierro Agostino , Hall Nigel J. 
Published: February 2017

CONTEXT:Nonoperative treatment (NOT) with antibiotics alone of acute uncomplicated appendicitis (AUA) in children has been proposed as an alternative to appendectomy.OBJECTIVE:To determine safety and efficacy of NOT based on current literature.DATA SOURCES:Three electronic databases.STUDY SELECTION:All articles reporting NOT for AUA in children.DATA EXTRACTION:Two reviewers independently verified study inclusion and extracted data.RESULTS:Ten articles reporting 413 children receiving NOT were included. Six, including 1 randomized controlled trial, compared NOT with appendectomy. The remaining 4 reported outcomes of children receiving NOT without a comparison group. NOT was effective as the initial treatment in 97% of children (95% confidence interval [CI] 96% to 99%). Initial length of hospital stay was shorter in children treated with appendectomy compared with NOT (mean difference 0.5 days [95% CI 0.2 to 0.8]; P = .002). At final reported follow-up (range 8 weeks to 4 years), NOT remained effective (no appendectomy performed) in 82% of children (95% CI 77% to 87%). Recurrent appendicitis occurred in 14% (95% CI 7% to 21%). Complications and total length of hospital stay during follow-up were similar for NOT and appendectomy. No serious adverse events related to NOT were reported.LIMITATIONS:The lack of prospective randomized studies limits definitive conclusions to influence clinical practice.CONCLUSIONS:Current data suggest that NOT is safe. It appears effective as initial treatment in 97% of children with AUA, and the rate of recurrent appendicitis is 14%. Longer-term clinical outcomes and cost-effectiveness of NOT compared with appendicectomy require further evaluation, preferably in large randomized trials, to reliably inform decision-making.
A Phase II Randomized Trial (GO27827) of First-Line FOLFOX Plus Bevacizumab with or Without the MET Inhibitor Onartuzumab in Patients with Metastatic Colorectal Cancer
Authors: Bendell Johanna C. , Hochster Howard , Hart Lowell L. , Firdaus Irfan , Mace Joseph R. , McFarlane Joshua J. , Kozloff Mark , Catenacci Daniel , Hsu Jessie J. , Hack Stephen P. , Shames David S. , Phan See-Chun , Koeppen Hartmut , Cohn Allen L. 
Published: February 2017

Abstract

Background
Dysregulated hepatocyte growth factor/mesenchymal-epithelial transition (MET) signaling is associated with poor prognosis and resistance to vascular endothelial growth factor inhibition in metastatic colorectal cancer (mCRC). We report outcomes from a double-blind, multicenter phase II trial of the MET inhibitor onartuzumab in combination with mFOLFOX-6 and bevacizumab for mCRC (GO27827; NCT01418222).

Materials and Methods
Patients were randomized 1:1 to receive onartuzumab (10 mg/kg intravenously [IV]) or placebo plus mFOLFOX-6 and bevacizumab (5 mg/kg IV). Oxaliplatin was given for 8–12 cycles; other agents were continued until disease progression, unacceptable toxicity, or death. The primary endpoint was progression-free survival (PFS) in the intent-to-treat (ITT) and MET immunohistochemistry (IHC) expression-positive populations.

Results
Between September 2011 and November 2012, 194 patients were enrolled. In September 2013, an interim analysis recommended stopping onartuzumab treatment due to lack of efficacy. At the time of the final analysis in February 2014, no significant improvement in PFS was seen with onartuzumab versus placebo in either the ITT or MET IHC-positive populations. An improvement in PFS was noted in the MET IHC-negative population. Neither overall survival nor response rate was improved with onartuzumab. The incidence of fatigue, peripheral edema, and deep vein thrombosis was increased with onartuzumab relative to placebo.

Conclusion
Onartuzumab combined with mFOLFOX-6 and bevacizumab did not significantly improve efficacy outcomes in either the ITT or MET IHC-positive populations. MET expression by IHC was not a predictive biomarker in this setting.
Pediatric, Adolescent, and Young Adult Thyroid Carcinoma Harbors Frequent and Diverse Targetable Genomic Alterations, Including Kinase Fusions
Authors: Vanden Borre Pierre , Schrock Alexa B. , Anderson Peter M. , Morris John C. , Heilmann Andreas M. , Holmes Oliver , Wang Kai , Johnson Adrienne , Waguespack Steven G. , Ou Sai-Hong Ignatius , Khan Saad , Fung Kar-Ming , Stephens Philip J. , Erlich Rachel L. , Miller Vincent A. , Ross Jeffrey S. , Ali Siraj M. 
Published: February 2017

Abstract

Background
Thyroid carcinoma, which is rare in pediatric patients (age 0–18 years) but more common in adolescent and young adult (AYA) patients (age 15–39 years), carries the potential for morbidity and mortality.

Methods
Hybrid-capture-based comprehensive genomic profiling (CGP) was performed prospectively on 512 consecutively submitted thyroid carcinomas, including 58 from pediatric and AYA (PAYA) patients, to identify genomic alterations (GAs), including base substitutions, insertions/deletions, copy number alterations, and rearrangements. This PAYA data series includes 41 patients with papillary thyroid carcinoma (PTC), 3 with anaplastic thyroid carcinoma (ATC), and 14 with medullary thyroid carcinoma (MTC).

Results
GAs were detected in 93% (54/58) of PAYA cases, with a mean of 1.4 GAs per case. In addition to BRAF V600E mutations, detected in 46% (19/41) of PAYA PTC cases and in 1 of 3 AYA ATC cases, oncogenic fusions involving RET, NTRK1, NTRK3, and ALK were detected in 37% (15/41) of PAYA PTC and 33% (1/3) of AYA ATC cases. Ninety-three percent (13/14) of MTC patients harbored RET alterations, including 3 novel insertions/deletions in exons 6 and 11. Two of these MTC patients with novel alterations in RET experienced clinical benefit from vandetanib treatment.

Conclusion
CGP identified diverse clinically relevant GAs in PAYA patients with thyroid carcinoma, including 83% (34/41) of PTC cases harboring activating kinase mutations or activating kinase rearrangements. These genomic observations and index cases exhibiting clinical benefit from targeted therapy suggest that young patients with advanced thyroid carcinoma can benefit from CGP and rationally matched targeted therapy.
An Intervention Study: Removing Supplemented Materials from Montessori Classrooms Associated with Better Child Outcomes
Authors: Lillard Angeline S , Heise Megan J 
Published: February 2017

Montessori classrooms vary a good deal in implementation, and one way in which implementation differs is the provision of materials. Specifically, some classrooms use only Montessori materials, whereas others supplement the Montessori materials with commercially available materials like puzzles and games. A prior study suggested this might be a reason for observed differences across studies and classrooms (Author, 2012) but an intervention study is the best test. The present study presents such an intervention with 52 children in 3 Montessori classrooms with Supplementary materials. All children were given 6 pretests, and non-Montessori materials were removed from 2 of the classrooms. Four months later, children were retested to see how much they changed across that period. Children in the classrooms from which the non-Montessori materials were removed advanced significantly more in early reading and executive function, and to some degree advanced more in early math. There were no differences across the classroom types in amount of change on the tests of vocabulary, social knowledge, or social skills.
THE PUBLIC SPHERE AS THE EDUCATION OF MULTICULTURALISM AWARENESS
Authors: - Yusar 
Published: February 2017

Abstract. This article was endeavor to describe the awareness multicultural education in the Chinese Lampion Festival in Kota Bandung since 2011 to 2013. The research was held with the longitudinal, qualitative, and adopt to the action research methods. The evidence was describe that the public sphere was success to build the communicative action between the native ethnics and the Chinese. By the public sphere, each ethnics perceived their cultural differences and appreciate as an equality. By this public sphere, the multiculturalism awareness was formed succesfully and reduce the ethnical stereotype between the native ethnics and the Chinese. This article conclude that the awareness multicultural education may be doing by creating the public spheres. Keywords: public sphere, education, multiculturalism Abstrak. Artikel ini menggambarkan pendidikan kesadaran multikulturalisme melalui perayaan Cap Go Meh. Etnis-etnis tempatan yang mengklaim sebagai pribumi memiliki stereotipe etnis yang kuat terhadap etnis Tionghoa. Penelitian telah dilakukan dengan paradigma kualitatif yang bersifat longitudinal mengadopsi pada metode action research. Hasil penelitian menunjukkan bahwa ruang publik yang dibangun antara etnis tempatan dengan etnis Tionghoa memunculkan tindakan komunikatif antar etnis. Melalui penciptaan ruang publik tersebut, kesadaran akan keberagaman muncul dari masing-masing etnis dan memadang bahwa budaya masing-masing berdiri setara dan muncul penghargaan atas masing-masing kebudayaan. Pemahaman multikulturalisme terbangun karena ruang publik yang diciptakan. Bagian penutup dijelaskan bahwa pendidikan kesadaran multikultur dapat ditempuh melalui penciptaan ruang-ruang publik. Kata kunci: ruang publik, pendidikan, multikulturalisme
THE APPLICATION OF TSTS MODEL IN CIVIC EDUCATION LESSON IN IMPROVING STUDENTS’ LEARNING ABILITY
Authors: Herfina Hanna 
Published: February 2017

Abstract, The background of this research is the need of various learning method to improve student’s learning ability. One of them is TSTS (two stay to stray). The purpose of this research is to examine TSTS learning method effectiveness in improving student’s learning ability and how much improvement made in implementing TSTS learning method. This research uses cooperative learning with two stay to stray (TSTS) model and action research method trial on learning process of PKn subject at Elementary School. The result of the research indicates improvement on students’ ability on PKn subject by using TSTS learning method, and the effectiveness of this model is proven with the increase of average score of 83.41%. TSTS model in First and Second cycle has proven, exponentially, contributes to the increase of students’ learning results. Keyword: effectiveness, learning method, TSTS model, Elementary School students. Abstrak, Penelitian ini dilatarbelakangi dengan adanya kebutuhan mengenai metode pembelajaran yang bervariasi untuk meningkatkan kemampuan belajar siswa, salah satunya dengan penerapan model pembelajaran TSTS. Adapun tujuan penelitian ini adalah untuk mengetahui efektivitas model pembelajaran TSTS dalam meningkatkan kemampuan belajar Siswa dan seberapa besar peningkatan kemampuan siswa dalam menerapkan model pembelajaran TSTS. Penelitian ini menggunakan konsep cooperative learning dengan model two stay to stray(TSTS), serta metode action research yang diujikan dalam proses belajar mengajar siswa Sekolah Dasar pada materi PKn. Sedangkan untuk hasil yang diperoleh adalah terdapat peningkatan kemampuanSiswa dalam pembelajaran PKn dengan model pembelajaran TSTS dan keefektifan melalui pemanfaatan model pembelajaran TSTS terbukti dengan meningkatnya nilai rata-rata sebesar83,41. Hal itu sudah menandakan bahwa penggunaan model TSTS di dalam siklus I dan II memberikan kontribusi yang sangat besar bagi peningkatan hasil belajar siswa.Kata kunci: efektivitas,metode pembelajaran, model TSTS, siswa SD.
THE PUBLIC RELATION LITIGATION STRATEGIES OF PT POS INDONESIA COMMUNICATION DIVISION IN DEALING WITH THE PROCUREMENT OF PERSONAL DATA TERMINAL
Authors: Widhiarti, dkk Chandra Kesuma 
Published: February 2017

Abstract, Strategic Public Relations is the way that has been planned to obtain a certain result. The result can be the purpose or goal of the objectives to be achieved by the company. Likewise with PT Pos Indonesia (Persero) which is handling the crisis through Litigation Public Relations. Crisis management must be done quickly and accurately so it requires careful planning. The purpose of this descriptive study was to determine strategies Public Relations Corporate Communications team, especially when the crisis is still being processed in court. Public Relations strategy is tailored to the stage of settling disputes in court. Keyword: Crisis, Litigation PR, Public Relations Public Relations Strategy Abstrak, Strategi Public Relations merupakan cara yang telah direncanakan untuk mendapatkan hasil tertentu. Hasil tersebut dapat berupa tujuan ataupun sasaran dari tujuan yang ingin dicapai oleh perusahaan. Demikian halnya dengan PT Pos Indonesia (Persero) yang tengah menangani krisis melalui Litigasi Public Relations. Penanganan krisis harus dilakukan dengan cepat dan tepat sehingga diperlukan perencanaan yang matang. Tujuan dari penelitian deskriptif ini adalah untuk mengetahui strategi Public Relations Tim Komunikasi Korporat khususnya ketika krisis masih diproses di Pengadilan. Strategi Public Relations tersebut disesuaikan dengan tahap penyelesaian perkara yang ada di Pengadilan.Kata Kunci: Strategi Public Relations, Litigasi PR, Krisis, Public Relations