bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Situ Disinfection through Photoinspired Radical Oxygen Species Storage and Thermal‐Triggered Release from Black Phosphorous with Strengthened Chemical Stability
Authors: Tan Lei , Li Jun , Liu Xiangmei , Cui Zhenduo , Yang Xianjin , Yeung Kelvin Wai Kwok , Pan Haobo , Zheng Yufeng , Wang Xianbao , Wu Shuilin 
Published: December 2017

AbstractPhotodynamic therapy (PDT) utilizing light‐induced reactive oxygen species (ROS) is a promising alternative to combat antibiotic‐resistant bacteria and biofilm. However, the photosensitizer (PS)‐modified surface only exhibits antibacterial properties in the presence of light. It is known that extended photoirradiation may lead to phototoxicity and tissue hypoxia, which greatly limits PDT efficiency, while ambient pathogens also have the opportunity to attach to biorelevant surfaces in medical facilities without light. Here, an antimicrobial film composed of black phosphorus nanosheets (BPSs) and poly (4‐pyridonemethylstyrene) endoperoxide (PPMS‐EPO) to control the storage and release of ROS reversibly is introduced. BPS, as a biocompatible PS, can produce high singlet oxygen under the irradiation of visible light of 660 nm, which can be stably stored in PPMS‐EPO. The ROS can be gradually thermally released in the dark. In vitro antibacterial studies demonstrate that the PPMS‐EPO/BPS film exhibits a rapid disinfection ability with antibacterial rate of 99.3% against Escherichia coli and 99.2% against Staphylococcus aureus after 10 min of irradiation. Even without light, the corresponding antibacterial rate reaches 76.5% and 69.7%, respectively. In addition, incorporating PPMS significantly improves the chemical stability of the BPS.
Cutting‐Edge Nanomaterials for Advanced Multimodal Bioimaging Applications
Authors: Tsang Ming‐Kiu , Wong Yuen‐Ting , Hao Jianhua 
Published: December 2017

AbstractThe desire for high sensitivity, resolution, low toxicity, and fast clearance contrast agents has driven the research for new nanomaterial systems. The drawbacks of traditional molecular probes limit their bioimaging ability, hence the exploration of emerging nanomaterials for multimodal bioimaging continues with rational designs. The key for realizing effective multimodal bioimaging is harnessing the physical and chemical properties of the nanomaterials. Although some nanomaterials possess multimodality intrinsically, those imaging modes may not be sufficient to meet the increasing demands of various applications. Therefore, the fabrication of novel composite structures by integrating various nanomaterials or molecules may overcome the challenging issues in multimodal bioimaging. An overview and considerations for multimodal bioimaging and the requirements regarding the nanomaterials are presented. The recently emerged nanomaterials and their composite structures for multimodal bioimaging are highlighted, including the recently emerging 2D materials. The traditional nanomaterials also show breakthroughs in terms of novel structures and morphologies, which would affect the contrast ability, entrance, and clearance from the in vivo models. Finally, some suggestions for toxicity studies of nanomaterials and new strategies are presented for realizing the advance of multimodal bioimaging.
Fawcettimine‐Type Lycopodium Alkaloids as a Driving Force for Discoveries in Organic Synthesis
Authors: Li Houhua , Lei Xiaoguang 
Published: December 2017

AbstractEver since the pioneering synthetic work reported by both Inubushi and Heathcock back in 1980s, the fawcettimine‐type Lycopodium alkaloids have continuously served as a driving force for discoveries in organic synthesis. In this personal account, we summarized our recent synthetic efforts towards the total synthesis of fawcettimine‐type Lycopodium alkaloids, along with a brief summary of relevant syntheses reported by others. Our discussions focus mainly on the key reactions applied during the synthesis of fawcettimine‐type Lycopodium alkaloids.
Antifibrotic effects of D‐limonene (5(1‐methyl‐4‐[1‐methylethenyl]) cyclohexane) in CCl4 induced liver toxicity in Wistar rats
Authors: Ahmad Sheikh Bilal , Rehman Muneeb U. , Fatima Bilques , Ahmad Bilal , Hussain Ishraq , Ahmad Sheikh Pervaiz , Farooq Adil , Muzamil Showkeen , Razzaq Rahil , Rashid Shahzada Mudasir , Ahmad Bhat Showkat , Mir Manzoor Ur Rahman 
Published: December 2017

AbstractThis study was designed to assess the potential antifibrotic effect of D‐Limonene—a component of volatile oils extracted from citrus plants. D‐limonene is reported to have numerous therapeutic properties. CCl4‐intduced model of liver fibrosis in Wistar rats is most widely used model to study chemopreventive studies. CCl4‐intoxication significantly increased serum aminotransferases and total cholesterol these effects were prevented by cotreatment with D‐Limonene. Also, CCl4‐intoxication caused depletion of glutathione and other antioxidant enzymes while D‐Limonene preserved them within normal values. Hydroxyproline and malondialdehyde content was increased markedly by CCl4 treatment while D‐Limonene prevented these alterations. Levels of TNF‐α, TGF‐β, and α‐SMA were also assessed; CCl4 increased the expression of α‐SMA, NF‐κB and other downstream inflammatory cascade while D‐Limonene co‐treatment inhibited them. Collectively these findings indicate that D‐Limonene possesses potent antifibrotic effect which may be attributed to its antioxidant and anti‐inflammatory properties.
Painting Writing, Writing Painting: Thinking, Seeing, and Problem Solving Through Story
Authors: Martens Prisca , Martens Ray , Doyle Michelle Hassay , Loomis Jenna , Fuhrman Laura , Stout Robbie , Soper Elizabeth 
Published: December 2017

AbstractThe purpose of this article is to share how the authors supported kindergartners’ and first graders’ developing creativity through stories they composed in writing and art. Over eight years, the authors explored ways to use picturebooks as mentor texts to help students explore how the authors and artists create meaning multimodally. This article shares minilessons and examples of how students creatively and imaginatively told their stories; learned to think, see, and reason; and invented and problem solved their stories, seamlessly weaving their meanings into writing and art.
Outbreak of porcine epidemic diarrhoea virus (PEDV) in Abruzzi region, central‐Italy
Authors: Pizzurro Federica , Cito Francesca , Zaccaria Guendalina , Spedicato Massimo , Cerella Angelo , Orsini Massimiliano , Forzan Mario , D'Alterio Nicola , Lorusso Alessio , Marcacci Maurilia 
Published: December 2017

AbstractHere we report and characterize a porcine epidemic diarrhea (PED) outbreak which occurred in a swine fattening farm in the province of Teramo, Abruzzi region (central Italy), in January 2016. PED virus (PEDV) identification was determined by real‐time RT‐PCR performed on RNAs purified from fecal samples collected from two symptomatic pigs. Whole genome sequence (PEDV 1842/2016) was also obtained by next generation sequencing straight from RNA purified from one fecal sample. Genome comparison with extant global PEDV strains revealed a high nucleotide identity with recently reported European and American S‐INDEL PEDVs. Efficient sequencing, share of genomic data combined with the implementation of epidemiological tools would be the ideal approach for study and analysis of transboundary infectious diseases as PED.
Justification and solvability of dynamical contact problems for generalized Marguerre–von Kármán shallow shells
Authors: Ghezal Abderrezak , Chacha Djamal Ahmed 
Published: December 2017

AbstractIn this work, we consider a three–dimensional dynamical model of unilateral contact problems with Signorini conditions and Coulomb friction laws for nonlinearly elastic shallow shells with a specific class of boundary conditions of generalized Marguerre–von Kármán type. Using technics from formal asymptotic analysis, we show that the scaled three–dimensional solution still leads to a two–dimensional dynamical model with frictionless contact problems. Then, we solve the last problems, using penalization method.
Impacts of Coastal Land Use and Shoreline Armoring on Estuarine Ecosystems: an Introduction to a Special Issue
Authors: Prosser Diann J. , Jordan Thomas E. , Nagel Jessica L. , Seitz Rochelle D. , Weller Donald E. , Whigham Dennis F. 
Published: December 2017

Abstract
The nearshore land-water interface is an important ecological zone that faces anthropogenic pressure from development in coastal regions throughout the world. Coastal waters and estuaries like Chesapeake Bay receive and process land discharges loaded with anthropogenic nutrients and other pollutants that cause eutrophication, hypoxia, and other damage to shallow-water ecosystems. In addition, shorelines are increasingly armored with bulkhead (seawall), riprap, and other structures to protect human infrastructure against the threats of sea-level rise, storm surge, and erosion. Armoring can further influence estuarine and nearshore marine ecosystem functions by degrading water quality, spreading invasive species, and destroying ecologically valuable habitat. These detrimental effects on ecosystem function have ramifications for ecologically and economically important flora and fauna. This special issue of Estuaries and Coasts explores the interacting effects of coastal land use and shoreline armoring on estuarine and coastal marine ecosystems. The majority of papers focus on the Chesapeake Bay region, USA, where 50 major tributaries and an extensive watershed (~ 167,000 km2), provide an ideal model to examine the impacts of human activities at scales ranging from the local shoreline to the entire watershed. The papers consider the influence of watershed land use and natural versus armored shorelines on ecosystem properties and processes as well as on key natural resources.
Using parent feedback: A&nbsp;qualitative study of residents’ and physician-educators’ perspectives
Authors: Eady Kaylee , Moreau Katherine A. 
Published: December 2017

Introduction Patients and family members can contribute to resident assessment in competency-based medical education. However, few studies have examined the use of patient/family member feedback generated from questionnaire-based assessments. To implement appropriate assessment strategies and optimize feedback use, we need to understand how residents and physician-educators would use feedback from these stakeholders. This study aimed to understand how paediatric residents and physician-educators would use parent feedback generated from questionnaire-based assessments.
Methods This study was conducted at a paediatric academic health science centre. We held dyadic interviews with six residents and six physician-educators. A three-step approach was used to analyze the data: data reduction, data display, and conclusions/verifications. We developed an initial coding scheme, conducted an in-depth review of the data and coded it, finalized our coding scheme, and identified categories.
Results Participants described that they would use parent feedback to: (a) provide additional direct observations of residents’ performances, (b) teach and coach residents, (c) assess residents’ overall performance and progression, and (d) encourage resident self-assessment and behaviour change.
Discussion Parents directly observe residents as they interact with them and their children and, therefore, can provide feedback on residents’ performances. Residency programs should include parent feedback and promote and facilitate its use by residents and physician-educators.
Conclusion This study provides an initial understanding of how paediatric residents and physician-educators would use parent feedback if they were to receive it. This information, combined with future research, can inform the development and implementation of parent feedback strategies in competency-based medical education.
SYSTEMIC RISK: AN ASYMPTOTIC EVALUATION
Authors: Asimit Alexandru V. , Li Jinzhu 
Published: December 2017

AbstractSystemic risk (SR) has been shown to play an important role in explaining the financial turmoils in the last several decades and understanding this source of risk has been a particular interest amongst academics, practitioners and regulators. The precise mathematical formulation of SR is still scrutinised, but the main purpose is to evaluate the financial distress of a system as a result of the failure of one component of the financial system in question. Many of the mathematical definitions of SR are based on evaluating expectations in extreme regions and therefore, Extreme Value Theory (EVT) represents the key ingredient in producing valuable estimates of SR and even its decomposition per individual components of the entire system. Without doubt, the prescribed dependence model amongst the system components has a major impact over our asymptotic approximations. Thus, this paper considers various well-known dependence models in the EVT literature that allow us to generate SR estimates. Our findings reveal that SR has a significant impact under asymptotic dependence, while weak tail dependence, known as asymptotic independence, produces an insignificant loss over the regulatory capital.
Palatal Tremor Revisited: Disorder with Nosological Diversity and Etiological Heterogeneity
Authors: Nagappa Madhu , Bindu Parayil S. , Sinha Sanjib , Bharath Rose D. , Sandhya Mangalore , Saini Jitender , Mathuranath Pavagada S. , Taly Arun B. 
Published: December 2017

AbstractThis case series aimed to describe clinicoradiological, electromyographic, and etiological spectra in palatal tremor (essential=1; symptomatic=26). Patients with symptomatic palatal tremor had 2 to 10 Hz arrhythmic electromyographic bursts, a spectrum of changes in inferior olivary nucleus, with/without lesions in Guillain Mollaret triangle, and varied etiologies (genetic=9, vascular=6, trauma=3, infections=3). Exome sequencing showed variations in POLG, WDR81, NDUFS8, TENM4, and EEF2. Clinical phenotypes of patients with POLG, WDR81, and NDUFS8 variations were consistent with that described in literature. We highlight salient magnetic resonance imaging features, electrophysiological observations, and diverse etiologies in a large cohort of palatal tremor.
Clinical Profile of Persons with Multiple Sclerosis Across the Continuum of Care
Authors: Turcotte Luke A. , Marrie Ruth Ann , Patten Scott B. , Hirdes John P. 
Published: December 2017

AbstractBackground:This study is part of the Innovations in Data, Evidence and Applications for Persons with Neurological Conditions project to understand the strengths, preferences, and needs of persons with neurological conditions living in Canada.Objective:To estimate the prevalence and describe the sociodemographic and clinical characteristics of persons with multiple sclerosis in Canadian home care, nursing home, Complex Continuing Care hospitals, and inpatient mental health care settings.Methods:Cross-sectional study of adults aged 18 years and older with multiple sclerosis (MS; n=11,250) across Canada from 1996 through 2011 using interRAI Resident Assessment Instrument (RAI) comprehensive health assessments (RAI Minimum Data Set 2.0, RAI-Home Care, RAI-Mental Health). Comparisons were made to adults with Alzheimer’s disease and related dementias (n=260,910), other neurological conditions (n=163,578) and non-neurological conditions (n=571,567).Results:The prevalence of MS was highest in Complex Continuing Care hospitals (4125 cases per 100,000 patients), followed by home care (2020 cases per 100,000 patients), nursing homes (1424 cases per 100,000 patients), and mental health settings (138 cases per 100,000 patients). Persons with MS experienced greater impairment in the completion of activities of daily living, pain, pressure ulcers, swallowing difficulty, depression, and anxiety compared with peers within care settings. There were also significant differences between settings, particularly the degree of physical and cognitive impairment experienced by persons with MS.Conclusions:Except for mental health care settings, the prevalence of MS in community, institutional and hospital-based care settings exceeded that of the general population. These data describing the sociodemographic and clinical characteristics of persons with MS may be used to inform clinical practice and policy decisions for persons with MS across the continuum of care.
Pathogen Distribution and Antimicrobial Resistance Among Pediatric Healthcare-Associated Infections Reported to the National Healthcare Safety Network, 2011–2014
Authors: Lake Jason G. , Weiner Lindsey M. , Milstone Aaron M. , Saiman Lisa , Magill Shelley S. , See Isaac 
Published: December 2017

OBJECTIVETo describe pathogen distribution and antimicrobial resistance patterns for healthcare-associated infections (HAIs) reported to the National Healthcare Safety Network (NHSN) from pediatric locations during 2011–2014.METHODSDevice-associated infection data were analyzed for central line-associated bloodstream infection (CLABSI), catheter-associated urinary tract infections (CAUTI), ventilator-associated pneumonia (VAP), and surgical site infection (SSI). Pooled mean percentage resistance was calculated for a variety of pathogen-antimicrobial resistance pattern combinations and was stratified by location for device-associated infections (neonatal intensive care units [NICUs], pediatric intensive care units [PICUs], pediatric oncology and pediatric wards) and by surgery type for SSIs.RESULTSFrom 2011 to 2014, 1,003 hospitals reported 20,390 pediatric HAIs and 22,323 associated pathogens to the NHSN. Among all HAIs, the following pathogens accounted for more than 60% of those reported:Staphylococcus aureus(17%), coagulase-negative staphylococci (17%),Escherichia coli(11%),Klebsiella pneumoniaeand/oroxytoca(9%), andEnterococcus faecalis(8%). Among device-associated infections, resistance was generally lower in NICUs than in other locations. For several pathogens, resistance was greater in pediatric wards than in PICUs. The proportion of organisms resistant to carbapenems was low overall but reached approximately 20% forPseudomonas aeruginosafrom CLABSIs and CAUTIs in some locations. Among SSIs, antimicrobial resistance patterns were similar across surgical procedure types for most pathogens.CONCLUSIONThis report is the first pediatric-specific description of antimicrobial resistance data reported to the NHSN. Reporting of pediatric-specific HAIs and antimicrobial resistance data will help identify priority targets for infection control and antimicrobial stewardship activities in facilities that provide care for children.Infect Control Hosp Epidemiol2018;39:1–11
Validation of bioelectrical impedance analysis in Ethiopian adults with HIV
Authors: Hegelund Maria H. , Wells Jonathan C. , Girma Tsinuel , Faurholt-Jepsen Daniel , Zerfu Dilnesaw , Christensen Dirk L. , Friis Henrik , Olsen Mette F. 
Published: December 2017

AbstractBioelectrical impedance analysis (BIA) is an inexpensive, quick and non-invasive method to determine body composition. Equations used in BIA are typically derived in healthy individuals of European descent. BIA is specific to health status and ethnicity and may therefore provide inaccurate results in populations of different ethnic origin and health status. The aim of the present study was to test the validity of BIA in Ethiopian antiretroviral-naive HIV patients.BIA was validated against the2H dilution technique by comparing fat-free mass (FFM) measured by the two methods using pairedttests and Bland–Altman plots. BIA was based on single frequency (50 kHz) whole-body measurements. Data were obtained at three health facilities in Jimma Zone, Oromia Region, South-West Ethiopia. Data from 281 HIV-infected participants were available. Two-thirds were female and the mean age was 32·7 (sd8·6) years. Also, 46 % were underweight with a BMI below 18·5 kg/m2. There were no differences in FFM between the methods. Overall, BIA slightly underestimated FFM by 0·1 kg (−0·1, 95 % CI −0·3, 0·2 kg). The Bland–Altman plot indicated acceptable agreement with an upper limit of agreement of 4·5 kg and a lower limit of agreement of −4·6 kg, but with a small correlation between the mean difference and the average FFM. BIA slightly overestimated FFM at low values compared with the2H dilution technique, while it slightly underestimated FFM at high values. In conclusion, BIA proved to be valid in this population and may therefore be useful for measuring body composition in routine practice in HIV-infected African individuals.
Evidence for trophic transfer ofInodosporus octosporaandOvipleistophora arlon. sp. (Microsporidia) between crustacean and fish hosts
Authors: Stentiford G.D. , Ross S. , Minardi D. , Feist S.W. , Bateman K.S. , Gainey P.A. , Troman C. , Bass D. 
Published: December 2017

AbstractWithin aquatic habitats, the hyper-abundant Order Crustacea appear to be the predominant host group for members of the Phylum Microsporidia. The musculature, a common site of infection, provides access to biochemical (carbohydrate-rich) and physiological (mitochondria-rich) conditions conducive to prolific parasite replication and maturation. The significant proportion of body plan devoted to skeletal musculature in Crustacea provides the location for a highly efficient intracellular parasite factory. In this study, we utilize histological, ultrastructural and phylogenetic evidence to describe a previously known (Inodosporus octospora) and novel (Ovipleistophora arlon. sp.) microsporidian parasites infecting the musculature of the common prawn (Palaemon serratus) from the same site, at the same time of year. Despite similar clinical signs of infection, both parasites are otherwise distinct in terms of pathogenesis, morphology and phylogeny. Based upon partial subunit ribosomal RNA (SSU rDNA) sequence, we show that thatI. octosporamay be identical to aKabatanasp. previously described infecting two-spot goby (Gobiusculus flavescens) in Europe, or at least thatInodosporusandKabatanagenera are synonyms. In addition, SSU rDNA sequence forO. arloplaces it within a distinct clade containingOvipleistophora mirandellaeandOvipleistophora ovariae, both infecting the oocytes of freshwater fish in Europe. Taken together, our data provide strong evidence for trophic-transfer between crustacean and fish hosts for two different microsporidians within clade 5 of the phylum. Furthermore, it demonstrates that morphologically and phylogenetically distinct microsporidians can infect the same tissues of the same host species to impart clinical signs which mimic infection with the other.
Social protection in the face of climate change: targeting principles and financing mechanisms
Authors: Carter Michael R. , Janzen Sarah A. 
Published: December 2017

AbstractThis paper builds a multi-generation household model of consumption, accumulation, and risk management to assess the dynamic consequences of climate risk exposure. The model incorporates long-term impacts of consumption shortfalls, induced by optimal ‘asset smoothing’ coping behavior of the vulnerable, on poverty. The analysis shows the long-term level and depth of poverty can be improved by incorporating ‘vulnerability-targeted social protection’ into a conventional social protection system. The paper further shows insurance-based vulnerability-targeted social protection dominates (in economic growth and poverty reduction measures) both in-kind transfers and asset-based vulnerability-targeted protection. We then stress test social protection mechanisms and find the relative performance of insurance-based vulnerability-targeted social protection improves when subjected to current pessimistic projections about increasing drought risk. However, if drought risk increases beyond current climate change projections, then even the vulnerability-targeted policy loses its ability to stabilize the extent and depth of poverty.