bluuebunny/crossref_metadata_2025_split huggingface dataset:
Latarjet Fixation
Authors: Alvi Hasham M. , Monroe Emily J. , Muriuki Muturi , Verma Rajat N. , Marra Guido , Saltzman Matthew D. 
Published: April 2016

Background: Attritional bone loss in patients with recurrent anterior instability has successfully been treated with a bone block procedure such as the Latarjet. It has not been previously demonstrated whether cortical or cancellous screws are superior when used for this procedure. Purpose: To assess the strength of stainless steel cortical screws versus stainless steel cannulated cancellous screws in the Latarjet procedure. Study Design: Controlled laboratory study. Methods: Ten fresh-frozen matched-pair shoulder specimens were randomized into 2 separate fixation groups: (1) 3.5-mm stainless steel cortical screws and (2) 4.0-mm stainless steel partially threaded cannulated cancellous screws. Shoulder specimens were dissected free of all soft tissue and a 25% glenoid defect was created. The coracoid process was osteomized, placed at the site of the glenoid defect, and fixed in place with 2 parallel screws. Results: All 10 specimens failed by screw cutout. Nine of 10 specimens failed by progressive displacement with an increased number of cycles. One specimen in the 4.0-mm screw group failed by catastrophic failure on initiation of the testing protocol. The 3.5-mm screws had a mean of 274 cycles (SD, ±171 cycles; range, 10-443 cycles) to failure. The 4.0-mm screws had a mean of 135 cycles (SD, ±141 cycles; range, 0-284 cycles) to failure. There was no statistically significant difference between the 2 types of screws for cycles required to cause failure ( P = .144). Conclusion: There was no statistically significant difference in energy or cycles to failure when comparing the stainless steel cortical screws versus partially threaded cannulated cancellous screws. Clinical Relevance: Latarjet may be performed using cortical or cancellous screws without a clear advantage of either option.
All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD+ leukemia stem cells in vitro and in vivo
Authors: Ma Hayley S. , Greenblatt Sarah M. , Shirley Courtney M. , Duffield Amy S. , Bruner J. Kyle , Li Li , Nguyen Bao , Jung Eric , Aplan Peter D. , Ghiaur Gabriel , Jones Richard J. , Small Donald 
Published: April 2016

Key Points
ATRA and FLT3 TKIs have synergistic activity against FLT3/ITD+ AML cell lines and patient samples. Combination reduces the leukemia stem cell population and improves survival in genetic and xenograft AML mouse models.
Hyperactive mTOR pathway promotes lymphoproliferation and abnormal differentiation in autoimmune lymphoproliferative syndrome
Authors: Völkl Simon , Rensing-Ehl Anne , Allgäuer Andrea , Schreiner Elisabeth , Lorenz Myriam Ricarda , Rohr Jan , Klemann Christian , Fuchs Ilka , Schuster Volker , von Bueren André O. , Naumann-Bartsch Nora , Gambineri Eleonora , Siepermann Kathrin , Kobbe Robin , Nathrath Michaela , Arkwright Peter D. , Miano Maurizio , Stachel Klaus-Daniel , Metzler Markus , Schwarz Klaus , Kremer Anita N. , Speckmann Carsten , Ehl Stephan , Mackensen Andreas 
Published: April 2016

Key PointsALPS DNT cells and their putative precursors reveal high proliferative activity in vivo, which is associated with hyperactive mTOR signaling. Rapamycin therapy controls mitotic activity and abnormal differentiation of ALPS DNT cells and reduces CD4+ or CD8+ precursor DNT cells.
Single- vs double-unit cord blood transplantation for children and young adults with acute leukemia or myelodysplastic syndrome
Authors: Michel Gérard , Galambrun Claire , Sirvent Anne , Pochon Cecile , Bruno Benedicte , Jubert Charlotte , Loundou Anderson , Yakoub-Agha Ibrahim , Milpied Noel , Lutz Patrick , Marie-Cardine Aude , Gandemer Virginie , Blaise Didier , Michallet Mauricette , Rialland Fanny , Renard Cecile , Oudin Claire , Esmiol Sophie , Seux Mylene , Baumstarck Karine , Mohty Mohamad , Rocha Vanderson , Dalle Jean-Hugues 
Published: April 2016

Key Points
A double-unit strategy does not decrease transplantation failure risk when a single unit of cord blood with adequate cell dose is available. Alloreactivity may be enhanced by double-unit cord blood transplantation.
Classification of the primary progressive aphasias: principles and review of progress since 2011
Authors: Vandenberghe Rik 
Published: April 2016

AbstractHighly influential recommendations published in 2011 for the classification of the primary progressive aphasias (PPA) distinguished three subtypes: the semantic variant, the nonfluent/agrammatic variant, and the logopenic variant. We review empirical evidence published after 2011 that bears relevance to the validity of the recommended classification scheme. The studies that we review principally rely on monocentric, memory clinic-based consecutive series of PPA patients. We review whether a data-driven analysis of neurolinguistic test scores confirms the subtyping that was based on expert consensus, whether the 2011 subtyping covers the diversity of PPA in a comprehensive manner, and whether the proposed subgroups differ along dimensions that are not explicitly part of the defining criteria, such as diffusion tractography. Data-driven mathematical analyses of neurolinguistic data in PPA broadly confirm the presence of separate clusters corresponding to the subtypes but also leave 15–30 % unclassified. A comprehensive description of PPA requires the addition of the mixed variant as a fourth subtype and needs to leave room for cases fulfilling the criteria for a root diagnosis of PPA but not those of any of the three subtypes. Finally, given the limited predictive value of the clinical phenotype for the underlying neuropathology, biomarkers of the underlying pathology are likely of clinical utility in PPA.
Οι "Caesares" του Αυσονίου. Παρατηρήσεις και επισημάνσεις
Authors: ΠΑΠΠΑΣ Βασίλειος Λ. 
Published: April 2016

Ausonius was a latin poet, born in Burdigala (Bordeaux), who, <em>inter alios</em>, composed the poetic work entitled "Caesares" between 379-383 A.D. This collection is an exposition of the lives of Roman emperors in verse (in hexameter and elegiac couplets). The collection is not complete. The work stops suddenly at the incomplete quatrain of Elagabalus. In this paper the author deals with the literary genre of the collection, the style of the poem, while he also attempts to trace the texts the poet used (Suetonius, Tacitus, the so[called <em>Kaisergeschichte</em>, Marius Maximus etc.). Finally he refers to the proposals concerning the missing part of the collection as put forth by various scholars in recent years.
Optimized purification strategies for the elimination of non-specific products in the isolation of GAD65-specific monoclonal autoantibodies
Authors: Jiang Wei , Macmillan Henriette , Madec Anne-Marie , Mellins Elizabeth D. 
Published: April 2016

Autoantibodies against antigens expressed by insulin-producing β cells are circulating in both healthy individuals and patients at risk of developing Type 1 diabetes. Recent studies suggest that another set of antibodies (anti-idiotypic antibodies) exists in this antibody/antigen interacting network to regulate auto-reactive responses. Anti-idiotypic antibodies may block the antigen-binding site of autoantibodies or inhibit autoantibody expression and secretion. The equilibrium between autoantibodies and anti-idiotypic antibodies plays a critical role in mediating or preventing autoimmunity. In order to investigate the molecular mechanisms underlying such a network in autoimmunity and potentially develop neutralizing reagents to prevent or treat Type 1 diabetes, we need to produce autoantibodies and autoantigens with high quality and purity. Herein, using GAD65/anti-GAD65 autoantibodies as a model system, we aimed to establish reliable approaches for the preparation of highly pure autoantibodies suitable for downstream investigation.
Orthopaedic device-related infection: current and future interventions for improved prevention and treatment
Authors: Moriarty T. Fintan , Kuehl Richard , Coenye Tom , Metsemakers Willem-Jan , Morgenstern Mario , Schwarz Edward M. , Riool Martijn , Zaat Sebastian A.J. , Khana Nina , Kates Stephen L. , Richards R. Geoff 
Published: April 2016

Orthopaedic and trauma device-related infection (ODRI) remains one of the major complications in modern trauma and orthopaedic surgery. Despite best practice in medical and surgical management, neither prophylaxis nor treatment of ODRI is effective in all cases, leading to infections that negatively impact clinical outcome and significantly increase healthcare expenditure. The following review summarises the microbiological profile of modern ODRI, the impact antibiotic resistance has on treatment outcomes, and some of the principles and weaknesses of the current systemic and local antibiotic delivery strategies. The emerging novel strategies aimed at preventing or treating ODRI will be reviewed. Particular attention will be paid to the potential for clinical impact in the coming decades, when such interventions are likely to be critically important. The review focuses on this problem from an interdisciplinary perspective, including basic science innovations and best practice in infectious disease.Cite this article: Moriarty TF, Kuehl R, Coenye T, et al. Orthopaedic device related infection: current and future interventions for improved prevention and treatment. EFORT Open Rev 2016;1:89-99. DOI: 10.1302/2058-5241.1.000037.
Developing a national quality registry for hand surgery: challenges and opportunities
Authors: Arner Marianne 
Published: April 2016

The Scandinavian National Healthcare Quality Registries (NQRs) have brought about considerable improvements since their introduction in the 1970s. One such registry – HAKIR (‘hand surgery’) – was established in 2010 and was likely the first NQR for hand surgery. Patient-reported outcome and reoperations due to post-operative complications are registered in HAKIR, as well as hand function in selected groups of surgical procedures. Creating simple logistics for collecting data and careful planning are important factors when establishing a new NQR. Continuous surveillance of data validity and coverage are crucial for success. With perseverance, large databases for clinical research can be created, along with the establishment of national multi-professional collaboration in healthcare improvement work.Cite this article: Arner, M. Developing a national quality registry for hand surgery: challenges and opportunities. EFORT Open Rev 2016;1:100-106. DOI: 10.1302/2058-5241.1.000045.
PRIORITIZATION OF SMALL BUSINESS ENTERPRISE OWNER CONCERNS ABOUT THE AFFORDABLE CARE ACT USING THE ANALYTIC HIERARCHY PROCESS
Authors: Gupta Rakesh M K , Makrigeorgis Christos 
Published: April 2016

<p>For almost a century, Americans lacked a comprehensive health care system. Upon the passage of the Affordable Care Act (ACA) in 2010, politicians, media, and lobbyists provided conflicting and confusing interpretations of the law. With such varied opinions, small business enterprise (SBE) owners became concerned about the potential adverse financial effects of the ACA. In this paper, we researched the problem by applying the Analytic Hierarchy Process (AHP) to create a ranking of the concerns of the SBE owners toward the ACA. A sample of 50 SBE owners representing 5 specific industry groups in Richmond, Virginia, was used to obtain a cross-sectional view of the concerns which allowed us to ascertain their uniformity or variability across these industry groups. The AHP sample data set was obtained via a pairwise comparison questionnaire. The AHP analysis revealed that the topmost SBE owners concerns were insurance premium, quality of care, and tax burden. In addition, these concerns were non-uniformly ranked among the industry groups. However, the highest and lowest concerns in each industry group were the same across the industry groups.</p><p> </p>
AHP BASED MULTICRITERIA COMPARATIVE ANALYSIS OF REGIONS OF EASTERN POLAND
Authors: Strojny Jacek 
Published: April 2016

<p>The modern economic landscape dynamically creates new and often difficult conditions in which all types of organizations must function. In management sciences literature the companies sector is the situation most often analyzed, yet it is also important to improve the management processes in public administration. The global economic crisis that started in 2008 assumed the form of a public finance crisis especially in developed economies. Public authorities are forced to meet the rising expectations of democratic societies while maintaining financial discipline. The pressure to optimize public spending constantly increases. Decision-making processes must therefore focus on the dimensions most relevant to the development of economic systems data. This research takes into account these realities, and focuses on the competitiveness of regions located in so-called Eastern Poland. The study uses a multi-criteria comparative analysis based on the AHP method. The procedure involved building models of competitiveness which systemize statistical variables describing the phenomenon of competitiveness. Based on these models, measurements were constructed and the level of competitiveness was calculated. The regions selected for the case study are separated according to the Polish cohesion policy due to their similar developmental problems. The author is very familiar with the context of development for the selected regions which makes the evaluation of the usefulness of the results obtained by the analysis easier.</p><p> </p>
Looking Forward to ISAHP2016 in London, UK!
Authors: Ferretti Valentina 
Published: April 2016

<p><em>We are looking forward to seeing you at the </em><a href="http://www.isahp.org"><strong><em>ISAHP 2016 Symposium</em></strong><em> </em></a><em>which will take place <strong>August 4 - 7, 2016, in London, UK</strong> !</em><em></em></p>
Heat Capacity and Its Variation with Moisture Content for Plywood and Oriented Strand Board Sheathing Produced by North American Mills
Authors: Rice Robert W. , Redfern Ian 
Published: April 2016

Abstract
The heat capacity of panels used for house sheathing is an important property that allows the hygrothermal modeling of thermal mass and the calculation of heating and cooling rates of certain types of walls. To our knowledge, this article presents the first data in over four decades for the measurement of heat capacity across a range of moisture content values. Although some estimates of panel heat capacity exist, few, if any, have been reported for mills across North America and across a range of moisture contents. The data clearly show the dependence of heat capacity on moisture content. They also show that solid wood and panel heat capacity values are similar at low moisture contents but diverge as moisture content increases. The variation in heat capacity with moisture content is large enough so that it should be considered when determining hygrothermal efficiency in walls containing plywood or oriented strand board or when developing hygrothermal models.
CO2 Laser–Incised Teak and Mahogany Lumber Dried by Microwave and Steam Injection
Authors: Listyanto Tomy , Ando Keisuke , Yamauchi Hidefumi , Hattori Nobuaki 
Published: April 2016

Abstract
The aim of this study was to investigate the application of microwave and steam injection drying on CO2 laser–incised teak (Tectona grandis) and mahogany (Swietenia mahagoni) lumber. The specimens were teak and mahogany lumber with dimensions of 60 by 120 by 600 mm. Three incising densities, 0, 1,250, and 2,500 holes per m2, were applied to the drying specimens. The drying process was carried out by a combination of microwave and steam injection drying. Microwave irradiation had a power of 3 kW at a frequency of 2.45 GHz, while steam injection drying was done by injecting superheated steam at 105°C to 110°C through a perforated plate at 110°C to 120°C. Drying rate, moisture content (MC) distribution, and checks were observed to evaluate the quality of the drying process. The results indicate that microwave heating and steam injection drying could successfully dry incised teak and mahogany lumber. The highest drying rate was achieved in the specimens with an incising density of 2,500 holes per m2. Interestingly, reducing the MC of teak from 46 to 20 percent required only 20 hours, while lowering the MC of mahogany from 60 to 20 percent took only 24 hours, without the formation of surface and internal checks. Laser incising, microwave heating, and the setting temperature of steam injection drying contributed considerably in creating a more uniform moisture distribution in teak and mahogany lumber, which significantly reduced surface and internal check formation.
Modeling of n-Hexadecane and Water Sorption in Wood
Authors: Baglayeva Ganna , Krishnamoorthy Gautham , Frihart Charles R. , Seames Wayne S. , O'Dell Jane , Kozliak Evguenii I. 
Published: April 2016

Abstract
Contamination of wooden framing structures with semivolatile organic chemicals is a common occurrence from the spillage of chemicals, such as impregnation with fuel oil hydrocarbons during floods. Little information is available to understand the penetration of fuel oil hydrocarbons into wood under ambient conditions. To imitate flood and storage scenarios, the sorption of n-hexadecane (representing fuel oil hydrocarbons) and water by southern yellow pine was studied using gravimetric techniques at ambient temperature and pressure. The sorption curves obtained had three distinct regions, reflecting three different sorption phases. Lower sorption coefficients were obtained for nonpolar n-hexadecane than for water, leading to n-hexadecane maximum mass uptake values being half those of water. Lower penetration values were obtained for epoxy-coated wood compared with uncoated wood, apparently because of the inaccessibility of diffusion paths along the wood lateral surface and slower air removal from tracheids. Two models were introduced to fit the observed sorption curves into a single algebraic equation, a diffusion (Fickian) model and an empirical (non-Fickian) equation. Effective diffusion coefficients were determined under the Fickian model, resulting in ca. 10−7 m2/s, 10−8 m2/s, and 10−10 to 10−11 m2/s diffusion rates for sorption in Phases 1, 2, and 3, respectively. The proposed non-Fickian model was based on first-order kinetic constants for the second sorption phase and fit the experimental data throughout all three phases. The two models were shown to corroborate each other by demonstrating that the effective surface areas of wood blocks calculated using both models' parameters were consistent with the corresponding expected physical values.
Evaluation of Mindray BC-6800 body fluid mode for automated cerebrospinal fluid cell counting
Authors: Buoro Sabrina , Seghezzi Michela , Mecca Tommaso , Vavassori Mauro , Crippa Alberto , La Gioia Antonio 
Published: April 2016

Abstract

Background:
Cellular analysis in cerebrospinal fluid (CSF) provides important diagnostic information in various medical conditions. The aim of this study was to evaluate the application of Mindray BC-6800 body fluid (BF) mode in cytometric analysis of CSF compared to light microscopy (LM).

Methods:
One hundred and twenty-nine consecutive CSF samples were analyzed by BC-6800-BF mode as well as by LM. The study also included limits of blank (LoB), limit of detection (LoD), limit of quantitation (LoQ), carryover and linearity.

Results
White blood cells LoQ was 4.0×106 cells/L. Linearity was good and carryover was negligible. As for the total and white blood cells, the BC-6800-BF parameters vs. LM showed both bias ranged from –10.28 to 0.06×106 cells/L. Polymorphonuclear and mononuclear cells ranged from 6.64 to 10.90%. For white blood cell the diagnostic agreement was 93% at the cut-off >5.0×106 cells/L, and for polymorphonuclear and mononuclear at the cut-off >50% was 91% and 92%, respectively.

Conclusions:
BC-6800-BF offers rapid and accurate counts in clinically relevant concentration ranges, replacing LM for most samples. However, in samples with abnormal cell counts or with abnormal white blood cell differential scattergrams the need to microscopic review for a correct clinical outcome remains.
TiCl2·2H2O catalyzed one-pot synthesis of highly functionalized tetrahydropiperidines and evaluation of their antimicrobial activities
Authors: Abbasi Mohsen , Seyedi Seyed Mohammad , Sadeghian Hamid , Akhbari Maryam , Enayaty Mohammadreza , Shiri Ali 
Published: April 2016

Abstract
One-pot condensation reaction of ethyl acetoacetate, various substituted benzaldehydes and anilines in the presence of TiCl2·2H2O yields highly functionalized tetrahydropiperidines. Atom economy, efficiency, and short reaction times are the advantages of the method, which is carried out under mild conditions using easily accessible and inexpensive chemicals. The antimicrobial activity of the synthesized products was evaluated against three Gram-positive and three Gram-negative bacteria, a yeast and a fungus strain using disc diffusion and minimum inhibitory concentration methods.
Optimal Energy Management for a Smart Grid using Resource-Aware Utility Maximization
Authors: Abegaz Brook W. , Mahajan Satish M. , Negeri Ebisa O. 
Published: April 2016

Abstract
Heterogeneous energy prosumers are aggregated to form a smart grid based energy community managed by a central controller which could maximize their collective energy resource utilization. Using the central controller and distributed energy management systems, various mechanisms that harness the power profile of the energy community are developed for optimal, multi-objective energy management. The proposed mechanisms include resource-aware, multi-variable energy utility maximization objectives, namely: (1) maximizing the net green energy utilization, (2) maximizing the prosumers’ level of comfortable, high quality power usage, and (3) maximizing the economic dispatch of energy storage units that minimize the net energy cost of the energy community. Moreover, an optimal energy management solution that combines the three objectives has been implemented by developing novel techniques of optimally flexible (un)certainty projection and appliance based pricing decomposition in an IBM ILOG CPLEX studio. A real-world, per-minute data from an energy community consisting of forty prosumers in Amsterdam, Netherlands is used. Results show that each of the proposed mechanisms yields significant increases in the aggregate energy resource utilization and welfare of prosumers as compared to traditional peak-power reduction methods. Furthermore, the multi-objective, resource-aware utility maximization approach leads to an optimal energy equilibrium and provides a sustainable energy management solution as verified by the Lagrangian method. The proposed resource-aware mechanisms could directly benefit emerging energy communities in the world to attain their energy resource utilization targets.