bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fully automatic left ventricular myocardial strain estimation in 2D short-axis tagged magnetic resonance imaging
Authors: Morais Pedro , Queirós Sandro , Heyde Brecht , Engvall Jan , ’hooge Jan D , Vilaça João L 
Published: August 2017

Abstract
Cardiovascular diseases are among the leading causes of death and frequently result in local myocardial dysfunction. Among the numerous imaging modalities available to detect these dysfunctional regions, cardiac deformation imaging through tagged magnetic resonance imaging (t-MRI) has been an attractive approach. Nevertheless, fully automatic analysis of these data sets is still challenging. In this work, we present a fully automatic framework to estimate left ventricular myocardial deformation from t-MRI. This strategy performs automatic myocardial segmentation based on B-spline explicit active surfaces, which are initialized using an annular model. A non-rigid image-registration technique is then used to assess myocardial deformation. Three experiments were set up to validate the proposed framework using a clinical database of 75 patients. First, automatic segmentation accuracy was evaluated by comparing against manual delineations at one specific cardiac phase. The proposed solution showed an average perpendicular distance error of 2.35  ±  1.21 mm and 2.27  ±  1.02 mm for the endo- and epicardium, respectively. Second, starting from either manual or automatic segmentation, myocardial tracking was performed and the resulting strain curves were compared. It is shown that the automatic segmentation adds negligible differences during the strain-estimation stage, corroborating its accuracy. Finally, segmental strain was compared with scar tissue extent determined by delay-enhanced MRI. The results proved that both strain components were able to distinguish between normal and infarct regions. Overall, the proposed framework was shown to be accurate, robust, and attractive for clinical practice, as it overcomes several limitations of a manual analysis.
BSviewer: a genotype-preserving, nucleotide-level visualizer for bisulfite sequencing data
Authors: Sun Kun , Lun Fiona F M , Jiang Peiyong , Sun Hao 
Published: August 2017

Abstract

Motivation
The bisulfite sequencing technology has been widely used to study the DNA methylation profile in many species. However, most of the current visualization tools for bisulfite sequencing data only provide high-level views (i.e. overall methylation densities) while miss the methylation dynamics at nucleotide level. Meanwhile, they also focus on CpG sites while omit other information (such as genotypes on SNP sites) which could be helpful for interpreting the methylation pattern of the data. A bioinformatics tool that visualizes the methylation statuses at nucleotide level and preserves the most essential information of the sequencing data is thus valuable and needed.

Results
We have developed BSviewer, a lightweight nucleotide-level visualization tool for bisulfite sequencing data. Using an imprinting gene as an example, we show that BSviewer could be specifically helpful for interpreting the data with allele-specific DNA methylation pattern.

Availability and implementation
BSviewer is implemented in Perl and runs on most GNU/Linux platforms. Source code and testing dataset are freely available at http://sunlab.cpy.cuhk.edu.hk/BSviewer/.
Infliximab Biosimilars: A Promising but Unusual Treatment for Mycobacterial Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients
Authors: Troya Jesús , Cuevas Guillermo , Ryan Pablo , Díez Victorino , Izquierdo Elsa , Escobar Ismael , Solís Javier 
Published: August 2017

AbstractImmune reconstitution inflammatory syndrome can present as a paradoxical reaction after initiation of antiretroviral treatment in patients with severe immunosuppression and underlying infections. Immune reconstitution inflammatory syndrome has often been associated with mycobacteria, and the clinical response to traditional treatment with corticosteroids is not always satisfactory. Consequently, administration of an infliximab biosimilar could lead to an improvement in the clinical status of these patients.
MentaLiST – A fast MLST caller for large MLST schemes
Authors: Feijao Pedro , Yao Hua-Ting , Fornika Dan , Gardy Jennifer , Hsiao Will , Chauve Cedric , Chindelevitch Leonid 
Published: August 2017

AbstractMLST (multi-locus sequence typing) is a classic technique for genotyping bacteria, widely applied for pathogen outbreak surveillance. Traditionally, MLST is based on identifying sequence types from a small number of housekeeping genes. With the increasing availability of whole-genome sequencing (WGS) data, MLST methods have evolved toward larger typing schemes, based on a few hundred genes (core genome MLST, cgMLST) to a few thousand genes (whole genome MLST, wgMLST). Such large-scale MLST schemes have been shown to provide a finer resolution and are increasingly used in various contexts such as hospital outbreaks or foodborne pathogen outbreaks. This methodological shift raises new computational challenges, especially given the large size of the schemes involved. Very few available MLST callers are currently capable of dealing with large MLST schemes.We introduce MentaLiST, a new MLST caller, based on ak-mer voting algorithm and written in the Julia language, specifically designed and implemented to handle large typing schemes. We test it on real and simulated data to show that MentaLiST is faster than any other available MLST caller while providing the same or better accuracy, and is capable of dealing with MLST scheme with up to thousands of genes while requiring limited computational resources. MentaLiST source code and easy installation instructions using a Conda package are available athttps://github.com/WGS-TB/MentaLiST.
Quantifying the recurring nature of fitout to assist LCA studies in office buildings
Authors: Forsythe Perry 
Published: August 2017

Purpose
The purpose of this paper is to quantify fitout churn in office buildings to more accurately evaluate the recurrent embodied energy in life cycle assessment studies.

Design/methodology/approach
Three research methods were used in the context of Central Business District (CBD) office buildings in Sydney. Method 1 involved leasing records from 528 office buildings; method 2, a leasing history from a selective sample of three prime grade office buildings; method 3, a targeted survey of 21 property professionals concerning fitout churn cycle estimates.

Findings
Prime buildings are the area of most interest to fitout churn because they represent a large proportion of total office floor area. The churn rate differs according to office tenancy type (as defined by small, medium and large leased areas). Large tenants occupy the majority of floor space. Lease duration as obtained from Method 1, offers a reasonable proxy for predicting fitout churn. Using this method coupled with weighted-average calculations, the data indicate a fitout churn rate of 8.2 years.

Research limitations/implications
Variability concerning the situational context of Sydney CBD office buildings restricts broad generalisability of the findings. However, the research method used in this study would enable broad-based comparison and the potential for verification.

Originality/value
The main contribution of the research is to improve the ability to accurately predict fitout churn cycles as previous work only involves limited case studies and arbitrary estimates, thus lacking a strong evidence based.
Optimal contract design for dual-channel supply chains under information asymmetry
Authors: Yang Honglin , Cao Erbao , Lu Kevin Jiang , Zhang Guoqing 
Published: August 2017

Purpose
The aim of this paper is to investigate the effect of information asymmetry on revenue sharing contracts and performance in a dual-channel supply chain. First, the authors model the optimum revenue sharing contract in a dual-channel supply chain under both the full information case and the asymmetric information case. Second, they contrast the optimal decisions of a dual-channel supply chain between the full information case and the asymmetric information case. Third, they explore the impact of asymmetric cost information on the performance of a dual-channel supply chain and investigate the information value.

Design/methodology/approach
The authors present two main issues associated with revenue sharing contracts to alleviate manufacturer–retailer conflicts in a dual-channel supply chain. In the first issue, a revenue sharing contract is designed in a dual-channel supply chain under asymmetric cost information conditions, based on the principal-agent model. In the second issue, an optimal revenue sharing contract under full information conditions, based on the Stackelberg game is discussed. They explore the impact of asymmetric cost information on the performance of a dual-channel supply chain and investigate the information value based on comparative static analysis.

Findings
First, the direct sale price is unchanged and independent of the retailer’s cost construct, but the wholesale price increases and the retail sale price does not decrease under asymmetric cost information. The information asymmetry leads to higher direct sale demand and lower retail sale demand. Second, information asymmetry is beneficial for the retailer, but imposes inefficiency on the manufacturer and the whole supply chain. Third, the performance of the dual-channel supply chain is improved if the retailer’s cost information is shared and the dual-channel supply chain reaches coordination. The retailer is willing to share its cost information if the lump sum side payment that the manufacturer offers can make up the retailer’s reduced profit due to sharing this information.

Originality/value
The authors proposed a contract menus design model in a dual-channel supply chain. They examine how information asymmetry affects optimal policies and performance. They compared the optimal policies under symmetric information and asymmetric information. Conditions under which the partners prefer sharing information are identified. They quantified the information value from the points of partners and the whole system.
Categorizing corporate social responsibility (CSR) initiatives in B2B markets: the why, when and how
Authors: Blenkhorn David L. , MacKenzie H.F. (Herb) 
Published: August 2017

PurposeThis paper aims to address the questions of why, when and how business-to-business (B2B) firms engage in sustainability initiatives. The authors believe that this is the first attempt to address all three questions in a single paper, and one of the earliest to focus on these in B2B markets.Design/methodology/approachThe sustainability initiatives of B2B firms throughout the value/supply chain were examined. Input data came from external sources and the firms themselves. Two conceptual frameworks were developed, illustrating why firms partake in sustainability initiatives and when and how they may do so.FindingsThis paper provides two conceptual frameworks that address why, when and how firms get involved in sustainability initiatives, and how they can better communicate their involvement to stakeholders.Research limitations/implicationsTo obtain a broader perspective of B2B firms’ involvement in sustainability initiatives, a variety of third-party sources were used, augmented with data from firm websites. Examples of firms the authors selected were constrained by the collection of firms described in student research papers.Practical implicationsThis paper suggests useful guidelines for firms considering starting or expanding sustainability initiatives by providing frameworks that address why, when and how firms do so, with examples of firms illustrating engagement in each area. It also provides communication guidelines, necessary for enhancing stakeholder relations.Social implicationsIntegrating environmental sustainability within a firm’s strategy can improve corporate image and increase efficiency, while contributing to a better world environment.Originality/valueA review of the corporate social responsibility (CSR) literature indicated that most research has focused on business-to-consumer markets. This paper addresses CSR in B2B markets, examining players at all levels of the value/supply chain: manufacturers, channel intermediaries and end-users.
Service-dominant logic and supply chain management: a systematic literature review
Authors: Altuntas Vural Ceren 
Published: August 2017

Purpose
This study aims to contribute to the scholarly fields of supply chain management (SCM) and service-dominant logic (SDL) by conducting a systematic literature review on business-to-business (B2B) marketing and SCM studies.

Design/methodology/approach
After the collection and refinement of 127 articles on SDL and SCM interface, descriptive and thematic analyses were applied to discover the current situation and the existing research streams in the literature.

Findings
The SDL-SCM literature focuses on five main research streams which are value co-creation and value-in-use, integration and relationship management, resource sharing, servitization and service supply chains. Each of them are explored in depth, and future research opportunities are proposed.

Research limitations/implications
The research is limited with the selected articles. Future scholarly attention to the intersection between SDL and SCM will enhance the knowledge on these fields.

Originality/value
The study contributes to both of these fields by summarizing the existing scholarly research and proposing research opportunities for scholars. It is one of the first efforts to systematically review the interface between SCM and SDL.
Identifying the resource conditions that maximize the relationship between ambidexterity and new product performance
Authors: Heirati Nima , O’Cass Aron , Sok Phyra 
Published: August 2017

Purpose
Organizational ambidexterity is argued to be a prerequisite for successful new product development, especially for firms operating in highly competitive emerging markets. Despite growing attention to the importance of ambidexterity, the conditions under which specific forms of ambidexterity are more or less beneficial to new product performance (NPP) remain unclear. This study aims to investigate the contingent value of two specific resource conditions that favor the pursuit of the balanced dimension versus combined dimension of ambidexterity to achieve superior NPP.

Design/methodology/approach
Survey data were drawn from a sample of 156 high-tech large firms operating in the Middle East and tested through a hierarchical regression analysis.

Findings
This study highlights the important role of slack resources and social networking capability in enhancing the benefits of the combined dimension of ambidexterity over the balanced dimension of ambidexterity to drive NPP.

Originality/value
This study extends prior research which has mainly examined organizational characteristics that facilitates organizational ambidexterity and sheds light on the specific resource conditions under which high-technology firms operating in an emerging economy should pursue balanced dimension of ambidexterity or combined dimension of ambidexterity to achieve superior NPP.
Social media capability in B2B marketing: toward a definition and a research model
Authors: Wang Yun , Rod Michel , Ji Shaobo , Deng Qi 
Published: August 2017

PurposeThe purpose of this study is to explore organizational social media capability in business-to-business (B2B) marketing, by focusing on what social media capability is in a B2B marketing context and how it is developed in firms engaged in B2B marketing.Design/methodology/approachThis is a thematic literature review, drawing on both B2B marketing and Information Systems literature. In total, 112 academic articles from nine journals were identified and analyzed. The findings were synthesized and compiled to provide answers to the predefined research questions.FindingsThe results suggest that organizational social media capability is dependent on a deep understanding of a firm’s technological capability, i.e. recognizing the key features and categories of social media and dynamically upgrading the recognition in response to the environmental change. A four-level Social Media Capability Maturity Model (technological, operational, managed and strategic level) that collectively transfers social media’s technological capability to dynamic organizational capability is proposed.Originality/valueThis study contributes to an understanding of the use of social media in the context of B2B marketing from an organizational dynamic capability perspective. The model is particularly relevant to organizations that have adopted or plan to adopt a B2B social media strategy and is relevant for B2B researchers who are interested in social media research.
Manifest conflict, customer orientation and performance outcomes in international buyer-seller relationships
Authors: Leckie Civilai , Widing Robert E. , Whitwell Gregory J. 
Published: August 2017

Purpose
The purpose of this paper is to test the impact of manifest conflict on performance outcomes. In particular, this paper aims to examine the moderating effect of the supplier’s customer orientation (CO) as perceived by the buyer on the conflict-performance outcomes relationships in international channel relationships.

Design/methodology/approach
A survey of 162 Australian importers was conducted to elucidate the associations among manifest conflict, CO and performance outcomes.

Findings
Manifest conflict was found to be negatively related to the importer’s evaluation of the exporter’s overall performance, which is consistent with previous work. However, CO was found to moderate the negative direct effect of manifest conflict on two outcome measures, “satisfaction with business outcomes” and the “evaluation of the exporter’s overall performance”. Moreover, it actually changed the effect from dysfunctional to functional for “evaluation of the exporter’s overall performance”. That is, CO changes the nature of the manifest conflict–outcome relationship by turning it from negative to positive.

Research limitations/implications
This research helps answer the appeal for research on the conditions in which conflict causes dysfunctional and functional outcomes. From a practical standpoint, providing the importer views the exporter as being customer-oriented, conflict should not be avoided if it stems from disagreements that arise due to the exporter acting in the best interests of the importer. The power of CO in affecting the functionality of outcomes resulting from conflict should be highlighted.

Originality/value
Conflict is a fact of life in channel relationships, but little is known about its functional and dysfunctional effects (Frazier, 1999; Skarmeas, 2006). The empirical evidence largely points to conflict being dysfunctional; however, research also indicates that context can play an important role in moderating the functionality of conflict. In this paper the authors ask: what role does CO play as a determinant of the functionality of manifest conflict in channel relationships? They argue that the exporter’s CO changes the context in which the importer and the exporter interact and, thereby, changes the way in which the importer interprets the supplier’s actions.
Experimental validation of the damage-plasticity modeling concept for normal strength concrete in fire
Authors: Neuenschwander Martin , Scandella Claudio , Knobloch Markus , Fontana Mario 
Published: August 2017

Purpose
This paper aims to investigate with strain-rate controlled uniaxial cyclic compression tests the softening behavior of concrete and its elastic stiffness degradation with increasing plastic straining.

Design/methodology/approach
Such tests at ambient temperature show that concrete exhibits the phenomenon of elastic stiffness degradation, which can be captured by damage-plasticity models.

Findings
The experimentally derived evolutions of the elastic stiffness with plastic strain confirm the suitability of the damage-plasticity modeling concept for concrete in compression at elevated temperatures and provide novel calibration data.

Originality/value
Temperature-dependent concrete models implementing this modeling concept are often used presently in structural fire engineering, despite the lack of experiment-based validation data.
Lead adsorption and subsequent gasification with Pinus elliottii waste
Authors: Antonelli Jhonatas , Lindino Cleber Antonio , Bariccatti Reinaldo Aparecido , Souza Samuel Nelson Melegari , Lenz Anderson Miguel 
Published: August 2017

Purpose
The purpose of this paper is to investigate the use of Pinus wood waste in lead adsorption as a remediation technique in aqueous medium and its subsequent use in obtaining synthesis gas.

Design/methodology/approach
The capacity of the timber in the lead adsorption was studied in aqueous medium at various pH, determining the amount adsorbed in equilibrium. Then, the same timber was added in a fixed bed, co-current flow of two stage gasifier type, working temperature of 900°C, for obtaining synthesis gas. The synthesis gas composition was evaluated by the spectrophotometry in the infrared region and the gas chromatography and lead content in the ash and gas was determined by the atomic absorption spectrophotometry.

Findings
In laboratory tests carried out, the optimal pH for lead removal was pH 4 with 96.15 percent removal rate, reaching equilibrium after 180 min. In pilot scale the lead removal after 72 hours was 96 percent. The average production of syngas was 11.09 m³h−1. For tests with the motor-generator, the best condition occurred with charge of 2.0 kW, wherein gas consumption per kW produced reached 4.86 m³ kW−1, resulting in a 14.81 percent efficiency rate. The gas analysis showed an average concentration of 14.85 percent H2, 30.1 percent CO2, and 50.49 percent of atmospheric air. The concentration of lead in the gas was below the limit established by law. Pinus elliottii waste proved to be an excellent adsorbent, with removing more than 96 percent of the Pb ion present in aqueous solution and a starting material in the gasifier to generate synthesis gas.

Research limitations/implications
This paper describes the waste wood application in the treatment of contaminated environments and for obtaining syngas providing a sustainable process.

Originality/value
This paper shows a process that combines the remediation of contaminated environmental with power generation systems, allowing efficient management of contaminated environments.