bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-reported outcome measures in a population of medically indigent patients with systemic lupus erythematosus in Puerto Rico
Authors: Rodríguez-Rivera Diana V , Rodríguez-Navedo Yerania , Nieves-Plaza Mariely , Vilá Luis M 
Published: September 2016

Objective: To determine patient-reported outcomes measures in indigent patients with systemic lupus erythematosus receiving their healthcare through the Puerto Rico government managed care system and compare these measures with non-indigent patients treated in a private fee-for-service setting. Methods: A cross-sectional study was conducted in a cohort of 98 Puerto Ricans with systemic lupus erythematosus. Patients from the public group (n = 40) were treated in a university-based specialized systemic lupus erythematosus clinic and the private group (n = 58) in a community-based rheumatology practice. Demographic and clinical features and patient-reported outcomes measures per LupusPRO instrument were determined. LupusPRO captures quality-of-life measures in 12 domains. Differences among study groups were examined using chi-square, Fisher’s exact, t-tests, and the Wilcoxon signed-rank test. Results: The mean (standard deviation) age of the study population was 44.9 (12.0) years; 94 (95.9%) were women. Patients in the public setting were younger and were more likely to have renal disease and elevated anti-double-stranded DNA antibodies, and being treated with azathioprine and cyclophosphamide. Patients from the public sector were more likely to have better quality-of-life measures in the LupusPRO domains of pain/vitality and coping. No significant differences were observed for the domains of lupus symptoms, physical health, emotional health, body image, cognition, procreation, lupus medications, desires/goals, social support, and satisfaction with medical care. Conclusion: Despite having a lower socioeconomic status and worse clinical status, systemic lupus erythematosus patients from the public sector had equal or better patient-reported outcomes measures than those treated in the private setting. This favorable outcome may be associated with the comprehensive healthcare received by these patients in a specialized lupus clinic.
Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation
Authors: Kato Hisashi , Nakazawa Yozo , Kurokawa Yumi , Kashiwagi Hirokazu , Morikawa Yoichiro , Morita Daisuke , Banno Fumiaki , Honda Shigenori , Kanakura Yuzuru , Tomiyama Yoshiaki 
Published: September 2016

Key PointsIn human CalDAG-GEFI deficiency, αIIbβ3 activation was impaired, but not agonist-induced neutrophil β2 integrin activation. Delayed αIIbβ3 activation kinetics was associated with severe bleeding tendency in CalDAG-GEFI deficiency.
Lung Ultrasonography for the Assessment of Perioperative Atelectasis: A Pilot Feasibility Study
Authors: Monastesse Audrey , Girard Francois , Massicotte Nathalie , Chartrand-Lefebvre Carl , Girard Martin 
Published: September 2016

BACKGROUND:
Few diagnostic tools are available to anesthesiologists when confronted with intraoperative hypoxemia. Lung ultrasonography is a safe and accurate bedside imaging modality. The aim of this study was to evaluate the feasibility of lung ultrasonography during the perioperative period and assess its ability to detect intraoperative respiratory complications and oxygenation changes resulting from perioperative atelectasis.

METHODS:
In this prospective observational pilot study, 30 consecutive patients scheduled for laparoscopic surgery were recruited. Mechanical ventilation was standardized. Lung ultrasonography was performed at 5 predefined time points: before induction of general anesthesia (GA), after induction of GA, after pneumoperitoneum insufflation, on arrival in the recovery room, and before recovery room discharge. For each echographic examination, 12 pulmonary quadrants were imaged. From these, a semiquantitative score, the lung ultrasound (LUS) score, was calculated to assess lung aeration at each time point.

RESULTS:
Lung ultrasonography was possible in all patients. Changes in the LUS score between the postinduction period and arrival in the recovery room were correlated with changes in oxygenation (Spearman r = −0.43, P = .018). Induction of GA was associated with an increase in the LUS score, which gradually worsened at all time points until recovery room discharge. This increase was significantly worse in the basal and dependent lung zones. Lung ultrasonography helped in the detection of 2 capnothoraces, 1 endobronchial intubation, and 1 episode of subclinical pulmonary edema.

CONCLUSIONS:
Lung ultrasonography in the perioperative period is feasible, allows tracking of perioperative atelectasis, and facilitates the diagnosis of respiratory complications. The evolution of aeration loss correlates moderately with changes in oxygenation.
An assessment of palliative care beliefs and knowledge: the healthcare provider's perspective
Authors: Patten Yvonne A. , Ojeda Maria M. , Lindgren Carolyn L. 
Published: September 2016

Research shows that healthcare providers' palliative care training and their misconceptions impact the delivery of care. As a result, the need for continuing education with adequate training is paramount to improve their knowledge and confidence in addressing the needs of patients and families facing serious illnesses. A pre-experimental static-group comparison design was used to determine if there was a significant difference in perceived competency and knowledge between healthcare providers who participated in a palliative care training programme and those who did not. A non-randomised sample of healthcare providers were administered a questionnaire to assess perceived competence and knowledge. Responses from 388 participants revealed a significant association between perceived competency and knowledge scores. The authors concluded that participation in a palliative care programme makes a significant difference in the healthcare provider's knowledge. However, further exploration is necessary to deduce the underlying reason for the negative association between perceived competency and knowledge.
What are the barriers to initiating end-of-life conversations with patients in the last year of life?
Authors: Travers Alice , Taylor Vanessa 
Published: September 2016

Introduction: Improving end of life care is a national imperative. Unsatisfactory care persists particularly in acute hospitals, with shortcomings, variability in communication and advance care planning identified as fundamental issues. This review explored the literature to identify what is known about the barriers to initiating end-of-life conversations with patients from the perspective of doctors and nurses in the acute hospital setting. Method: Six electronic databases were searched for potentially relevant records published between 2008 and 2015. Studies were included if the authors reported on barriers to discussing end of life with families or patients as described by doctors or nurses in hospital settings, excluding critical care. Results: Of 1267 potentially relevant records, 12 were included in the review. Although there is limited high-quality evidence available, several barriers were identified. Recurrent themes within the literature related to a lack of education and training, difficulty in prognostication, cultural differences and perceived reluctance of the patient or family. Conclusions: This study illustrated that, in addressing barriers to communication, consideration needs to be extended to include how to embed good communication practice between patients and health professionals into the culture of this setting. Board level commitment is required to raise awareness of, and familiarity with, policies and protocols concerning communication and end-of-life care. Communication training should include practical skills and tools, opportunities to explore the personal beliefs of practitioners and managing their emotions, opportunities to analyse the local organisational (physical and social environment) and team barriers.
Vertical and Horizontal Impact Force Comparison During Jump Landings With and Without Rotation in NCAA Division I Male Soccer Players
Authors: Harry John R. , Barker Leland A. , Mercer John A. , Dufek Janet S. 
Published: September 2016

Abstract
Harry, JR, Barker, LA, Mercer, JA, and Dufek, JS. Vertical and horizontal impact force comparison during jump landings with and without rotation in NCAA Division I male soccer players. J Strength Cond Res 31(7): 1780–1786, 2017—There is a wealth of research on impact force characteristics when landing from a jump. However, there are no data on impact forces during landing from a jump with an airborne rotation about the vertical axis. We examined impact force parameters in the vertical and horizontal axes during vertical jump (VJ) landings and VJ landings with a 180° rotation (VJR). Twenty-four Division I male soccer players performed 3 VJ and VJR landings on a dual-force platform system. Paired-samples t-tests (α = 0.05) compared differences in the first (F1) and second (F2) peak vertical ground reaction forces, times to F1 (tF1), F2 (tF2), and the end of the impact phase, vertical impulse, and anterior-posterior and medial-lateral force couples. Effect sizes (ES; large >0.8) were computed to determine the magnitude of the differences. Lower jump height (41.60 ± 4.03 cm, VJ landings; 39.40 ± 4.05 cm, VJR landings; p = 0.002; ES = 0.39), greater F2 (55.71 ± 11.95 N·kg−1, VJ; 68.16 ± 14.82 N·kg−1; p < 0.001; ES = 0.94), faster tF2 (0.057 ± 0.012 seconds, VJ; 0.047 ± 0.011 seconds, VJR; p = 0.001; ES = 0.89), greater anterior-posterior (0.06 ± 0.03 N·s·kg−1, VJ; 0.56 ± 0.15 N·s·kg−1, VJR; p < 0.001; ES = 1.83) and medial-lateral force couples (0.29 ± 0.11 N·s·kg−1, VJ; 0.56 ± 0.14 N·s·kg−1, VJR; p < 0.001; ES = 1.46) occurred during VJR landings. No other differences were identified. This kinetic analysis determined that landing from a jump with 180° airborne rotation is different than landing from a jump without an airborne rotation. Male Division I soccer players could benefit from increasing the volume of VJR landings during training to address the differences in jump height and force parameters compared with VJ landings.
The Perceived Psychological Responsibilities of a Strength and Conditioning Coach
Authors: Radcliffe Jon N. , Comfort Paul , Fawcett Tom 
Published: September 2016

Abstract
Radcliffe, JN, Comfort, P, and Fawcett, T. The perceived psychological responsibilities of a strength and conditioning coach. J Strength Cond Res 32(10): 2853–2862, 2016—Research is limited in exploring the specific psychology-oriented responsibilities of the strength and conditioning professional. The present research explored the psychological responsibilities adopted by accredited strength and conditioning coaches. Participants comprised 10 coaches working within the United Kingdom, 3 within the United States, and 5 within Australia offering a cross-section of experience from various sport disciplines and educational backgrounds. Participants were interviewed either in person or via Skype. Thematic clustering was followed using interpretative phonological analysis to identify common themes. Over half (61%) of the respondents reported that their position as a strength and conditioning coach required additional psychology-oriented responsibilities. These comprised a counseling role in the absence of a psychologist and the use of “softer skills” in a mentoring role to the athlete during a challenging situation. The coach could play an influential role in shaping the mentality of the team. The coach identifies how the role results in working to relay information from the athlete to other support staff and similarly from the support staff to the athlete. In addition to identifying the resonant psychology-oriented responsibilities, discussion is made with specific focus on the ethical boundary within which strength and conditioning coaches must reside regarding the competencies to provide psychological support.
Reliability and Validity of the Load–Velocity Relationship to Predict the 1RM Back Squat
Authors: Banyard Harry G. , Nosaka Kazunori , Haff G. Gregory 
Published: September 2016

Abstract
Banyard, HG, Nosaka, K, and Haff, GG. Reliability and validity of the load–velocity relationship to predict the 1RM back squat. J Strength Cond Res 31(7): 1897–1904, 2017—This study investigated the reliability and validity of the load–velocity relationship to predict the free-weight back squat one repetition maximum (1RM). Seventeen strength-trained males performed three 1RM assessments on 3 separate days. All repetitions were performed to full depth with maximal concentric effort. Predicted 1RMs were calculated by entering the mean concentric velocity of the 1RM (V1RM) into an individualized linear regression equation, which was derived from the load–velocity relationship of 3 (20, 40, 60% of 1RM), 4 (20, 40, 60, 80% of 1RM), or 5 (20, 40, 60, 80, 90% of 1RM) incremental warm-up sets. The actual 1RM (140.3 ± 27.2 kg) was very stable between 3 trials (ICC = 0.99; SEM = 2.9 kg; CV = 2.1%; ES = 0.11). Predicted 1RM from 5 warm-up sets up to and including 90% of 1RM was the most reliable (ICC = 0.92; SEM = 8.6 kg; CV = 5.7%; ES = −0.02) and valid (r = 0.93; SEE = 10.6 kg; CV = 7.4%; ES = 0.71) of the predicted 1RM methods. However, all predicted 1RMs were significantly different (p ≤ 0.05; ES = 0.71–1.04) from the actual 1RM. Individual variation for the actual 1RM was small between trials ranging from −5.6 to 4.8% compared with the most accurate predictive method up to 90% of 1RM, which was more variable (−5.5 to 27.8%). Importantly, the V1RM (0.24 ± 0.06 m·s−1) was unreliable between trials (ICC = 0.42; SEM = 0.05 m·s−1; CV = 22.5%; ES = 0.14). The load–velocity relationship for the full depth free-weight back squat showed moderate reliability and validity but could not accurately predict 1RM, which was stable between trials. Thus, the load–velocity relationship 1RM prediction method used in this study cannot accurately modify sessional training loads because of large V1RM variability.
Strength and Conditioning for Throwing in Cricket
Authors: Cronin John B. , Sharp Anthony P. , Stronach Bryan , Deuchrass Richard , Bressel Eadric , Shackel Dayle F. , McMaster Daniel T. 
Published: September 2016

ABSTRACT
IN CRICKET, THE ABILITY TO THROW A BALL AT HIGH VELOCITY WITH GREAT ACCURACY IS CRITICAL TO SUCCESSFUL PERFORMANCE AND OFTEN DETERMINES THE OUTCOME OF MATCHES. THE SKILL OF CRICKET FIELDING INCORPORATES A MOVEMENT PHASE AND A PICK-UP AND THROW PHASE AIMED AT DECREASING RUN RATE OR PRODUCING A RUN OUT OF THE OPPOSITION. A MAJOR ISSUE IN CRICKET IS THE RISK OF INJURY TO PLAYERS ATTRIBUTED TO AN ACUTE SPIKE IN THROWING INTENSITY AND VOLUME DURING PRACTICE AND MATCHES. THIS ARTICLE DISCUSSES STRENGTH AND CONDITIONING PRACTICES THAT MAY REDUCE THE PREVALENCE OF THROWING-RELATED INJURIES AND IMPROVE THROWING PERFORMANCE.
Comportamento e valores políticos de eleitores
Authors: Veiga Luciana 
Published: September 2016

Estudos (DALTON, 2002) vem apontando para o crescimento de dois tipos de eleitores nas últimas décadas: o eleitor apartidário, mas sofisticado cognitivamente e mobilizado em relação ao tema da política, e o eleitor partidário sem muitos recursos cognitivos e informação sobre os assuntos políticos.Tais perfis contrariam as descrições dos eleitores partidários e apartidários dos anos 60 (CAMPBELL, 1960). Buscamos, assim, aplicar a tipologia inspirado em DALTON (2008), que classifica os eleitores de acordo com duas variáveis: preferência partidária e sofisticação cognitiva sobre assuntos da política. A partir de análise de surveys do Estudo Eleitoral Brasileiro, realizados em 2002 e 2006, a intenção é verificar se os quatro tipos de eleitores se diferenciam no procedimento da escolha do voto e nos valores envolvidos neste comportamento (identificação ideológica e preferência partidária, grau de satisfação com os governos e avaliação da imagem do político). Os resultados encontrados apontam que há muitas similaridades sobre os procedimentos da escolha – todos disseram priorizar os temas/propostas, em seguida o passado e a imagem do político, e por último o partido ao elaborarem a sua decisão. Muitas são as diferenças sobre a avaliação do governo e, principalmente, sobre a avaliação de candidato, em 2002, e também presidente em 2006, Lula.
No Brasil, rádio e televisão influenciam relações políticas nas instâncias de poder
Authors: Correia Genira Chagas 
Published: September 2016

<p><strong>RESUMO</strong></p><p><em>Este texto busca apontar aspectos da radiodifusão brasileira – rádio e televisão – a partir de análise da legislação, visando reforçar o entendimento da influência desses meios sobre os acontecimentos políticos, reconhecidos posteriormente como parte da História. Problematiza-se a utilização desses instrumentos como instância de força em sucessivos governos – de Getúlio Vargas a João Goulart –, apontando como a visibilidade modifica as relações políticas nas instâncias do poder. </em></p>
TAP-Dependent and -Independent Peptide Import into Dendritic Cell Phagosomes
Authors: Lawand Myriam , Abramova Anastasia , Manceau Valérie , Springer Sebastian , van Endert Peter 
Published: September 2016

Abstract
Cross-presentation of phagocytosed Ags by MHC class I (MHC-I) molecules is thought to involve transport of cytosolic peptides into dendritic cell phagosomes, mediated by TAP transporters recruited from the endoplasmic reticulum. However, because pure and tightly sealed phagosomes are difficult to obtain, direct evidence for peptide transport into phagosomes has remained limited. Moreover, the parameters determining peptide uptake by, and survival in, phagosomes remain little characterized. In this study, we monitored peptide import into phagosomes by flow cytometry using two types of fluorescent reporter peptides, one of which directly bound to intraphagosomal beads. We observed that a peptide with high TAP affinity is imported into phagosomes in a TAP- and ATP-dependent manner, as expected. However, surprisingly, import of the OVA peptide SIINFEKL, a CD8+ T cell epitope frequently used to study cross-presentation, is ATP-dependent but substantially TAP-independent. The half-life of both reporter peptides is shortened by enhanced phagosome maturation triggered by TLR signaling. Conversely, formation of complexes with MHC-I molecules enhances peptide accumulation in phagosomes. Collectively, these results confirm that TAP can import peptides into phagosomes, but they suggest that some peptides, including the popular SIINFEKL, can enter phagosomes also via a second unknown energy-dependent mechanism. Therefore, the frequently reported TAP dependence of cross-presentation of phagocytosed OVA may principally reflect a requirement for recycling MHC-I molecules rather than SIINFEKL import into phagosomes via TAP.
JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages
Authors: Hedl Matija , Proctor Deborah D. , Abraham Clara 
Published: September 2016

Abstract
JAK2 genetic variants are associated with inflammatory bowel disease (IBD) and JAK inhibitors are being evaluated for therapy targeting immune-mediated diseases, including IBD. As JAK pathway-mediated cytokine regulation varies across cell types and stimulation conditions, we examined how JAK signaling and IBD-associated JAK2 variants regulate distinct acute and chronic microbial product exposure outcomes in human myeloid cells, consistent with the conditions of initial entry and ongoing intestinal tissue residence, respectively. Macrophages from controls and ulcerative colitis patients carrying the IBD-risk rs10758669 CC genotype showed increased JAK2 expression and nucleotide-binding oligomerization domain 2-induced JAK2 phosphorylation relative to AA carriers. Interestingly, the threshold of JAK2 expression and signaling determined pattern-recognition receptor (PRR)-induced outcomes; whereas anti-inflammatory cytokines progressively decreased with lower JAK2 expression, proinflammatory cytokines switched from decreased to increased secretion below a certain JAK2 expression threshold. Low JAK2-expressing rs10758669 AA macrophages were above this threshold; consequently, both PRR-induced pro- and anti-inflammatory cytokines were decreased. However, relative to rs10758669 CC risk carriers, AA carrier macrophages switched to increased nucleotide-binding oligomerization domain 2-induced proinflammatory cytokines at lower therapeutically used JAK inhibitor doses. Importantly, JAK inhibitors increased proinflammatory cytokines secreted by peripheral macrophages following chronic PRR stimulation and by human intestinal myeloid cells following exposure to intestinal pathogens. Mechanistically, the decreased response to and secretion of autocrine/paracrine IL-10, IL-4, IL-22 and thymic stromal lymphopoietin regulated these JAK-dependent outcomes in myeloid cells. Taken together, the JAK signaling threshold determines whether PRR-induced pro- and anti-inflammatory cytokines are reciprocally regulated in myeloid cells; consideration of JAK2 genotype and targeting of specific cell types might improve JAK-targeted therapy in immune-mediated diseases.