bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of the early administration of valacyclovir hydrochloride for the treatment of neuropathogenic equine herpesvirus type-1 infection in horses
Authors: Maxwell Lara K. , Bentz Bradford G. , Gilliam Lyndi L. , Ritchey Jerry W. , Pusterla Nicola , Eberle R. , Holbrook Todd C. , McFarlane Dianne , Rezabek Grant B. , Meinkoth James , Whitfield Chase , Goad Carla L. , Allen George P. 
Published: September 2017

Abstract
OBJECTIVE To determine whether prophylactic administration of valacyclovir hydrochloride versus initiation of treatment at the onset of fever would differentially protect horses from viral replication and clinical disease attributable to equine herpesvirus type-1 (EHV-1) infection.
ANIMALS 18 aged mares.
PROCEDURES Horses were randomly assigned to receive an oral placebo (control), treatment at detection of fever, or prophylactic treatment (initiated 1 day prior to viral challenge) and then inoculated intranasally with a neuropathogenic strain of EHV-1. Placebo or valacyclovir was administered orally for 7 or 14 days after EHV-1 inoculation or detection of fever (3 horses/group). Effects of treatment on viral replication and clinical disease were evaluated. Plasma acyclovir concentrations and viremia were assessed to determine inhibitory concentrations of valacyclovir.
RESULTS Valacyclovir administration decreased shedding of virus and viremia, compared with findings for control horses. Rectal temperatures and clinical disease scores in horses that received valacyclovir prophylactically for 2 weeks were lower than those in control horses. The severity of but not the risk for ataxia was decreased by valacyclovir administration. Viremia was decreased when steady-state trough plasma acyclovir concentrations were > 0.8 μg/mL, supporting the time-dependent activity of acyclovir.
CONCLUSIONS AND CLINICAL RELEVANCE Valacyclovir treatment significantly decreased viral replication and signs of disease in EHV-1–infected horses; effects were greatest when treatment was initiated before viral inoculation, but treatment was also effective when initiated as late as 2 days after inoculation. During an outbreak of equine herpesvirus myeloencephalopathy, antiviral treatment may be initiated in horses at various stages of infection, including horses that have not yet developed signs of viral disease.
Simulasi dan Verifikasi Prestasi Terbang Model Remote Control Flying Boat Saat Hidroplaning
Authors: Syamsuar Sayuti 
Published: September 2017

Pesawat Wing In Surface Effect A2B tipe B konfigurasi Lippisch mempunyai hambatan air yang cukup besar dibandingkan tenaga mesin saat hydroplaning. Makalah ini berisikan bagian dari analisis dalam perancangan untuk mengetahui karakteristik aerodinamika dan hidrodinamika dari remote control model jenis Flying Boat pada fase hydroplaning. Pada awalnya, dilakukan pemotretan 3D terhadap pesawat model Flying Boat menggunakan kamera laser untuk menghasilkan solid drawing pada program CATIA. Model 3D dianalisis dengan menggunakan piranti lunak CFx pada program AnSys. Planform sayap, memiliki dihedral dan menggunakan airfoil jenis NACA 23012. Karakteristik aerodinamika dan hidrodinamika untuk model 3 D dipresentasikan pada posisi sudut alpha =00. Sedangkan kecepatan yang digunakan adalah 0 sampai25 knots. Untuk memverifikasi data hasil simulasi, digunakan data uji terbang pesawat udara tanpa awak Alap-alap yang mempunyai T/W rasio yang sama, yaitu sudut pitch, kecepatan arah sumbu Z pada sumbu benda, ketinggian dan kecepatan. Gaya angkat aerodimaka arah sumbu Z pada simulasi RC model Flying Boat sebanding dengan gaya angkat aerodinamika arah sumbu Z pada UAV Alap-alap saat take off.
[The Hydroplaning Flight Performance Simulation and Verfication of a Flying Boat Remote Control Model] The Wing in Surface Effect Aircraft A2B type B with Lippisch configuration has higher hydrodynamics drag compared to engine powered aircraft during hydroplaning. This paper explains parts of analysis in aircraft design to identify the aerodynamics and hydrodynamics characteristics of flying boat remote control model during hydroplaning phase. At first, flying boat model was three dimensional photographed using laser camera in order to produce solid drawing for CATIA program. The three dimensional model, later, analyzed by using CFx software in AnSys program. The wing planform has dihedral angle while the airfoil used is NACA 23012. The aerodynamics and hydrodynamics characteristics of this three-dimensional model is represented for alpha =00. Whilst the speed used in simulation was 0 to 25 knots. In verifying the data of the simulation results, the Unmanned Aerial Vehicle UAV Alap-alap flight test data was used in which it has the same T/W ratio for the pitch angle, acceleration in Z body axis, altitude, and speed. The aerodynamics lift in Z axis of flying boat model during simulation is proportional to the aerodynamics lift in Z axis of UAV Alap-alap during take-off.
Kajian Desain Kelaiktabrakan Pesawat Terbang
Authors: Jusuf Annisa , Afdhal Afdhal , Mora Minda 
Published: September 2017

Lalu lintas penerbangan di Indonesia mengalami tren peningkatan dari tahun ke tahun. Peningkatan frekuensi penggunaan pesawat terbang tentunya akan meningkatkan kemungkinan kejadian kecelakaan. Konsep kelaiktabrakan pesawat terbang menjadi hal penting yang perlu mendapat perhatian untuk mencegah kerusakan struktur dan cedera pada penumpang. Desain kelaiktabrakan struktur pesawat berada pada tahapan desain awal yang terintegrasi kedalam proses desain pesawat secara keseluruhan. Struktur subfloor pada pesawat terbang menjadi bagian yang digunakan untuk menyerap energi kinetik tabrakan dalam kasus pembebanan vertikal pada pesawat terbang. Crash box merupakan komponen pada subfloor yang akan menyerap energi kinetik tabrakan dengan mengubahnya menjadi deformasi plastis.
[A Review of Aircraft Crashworthiness Design] Air traffic in Indonesia is experiencing a positive trend in recent years. The increase in the frequency of aircraft operation might particularly increase the possibility of accidents occurrence. Aircraft crashworthiness concept becomes an important matter that need to be considered in order to prevent structural damage and injuries to the passengers. Aircraft structural crashworthiness design is developed in the aircraft preliminary design phase which is, later, integrated into the overall aircraft design process. Aircraft subfloor structure is the part of the aircraft that is used to restrain the kinetic energy of a collision in the case of vertical loading on the aircraft. Subsequently, crash box is a component of the subfloor that will absorb collisions kinetic energy by turning it into plastic deformation.
Desain dan Eksperimen Uji Getaran di Tanah dari Model Separuh Sayap Pesawat N219
Authors: Syamsuar Sayuti , Gunawan Leonardo , Widiramdhani Martina , Kartika Nina 
Published: September 2017

Fenomena flutter merupakan salah satu fenomena yang kritis dan dapat membahayakan pesawat. Ketika, pesawat terbang semakin cepat dan mencapai kecepatan flutter, maka akan terjadi ketidakstabilan struktur. Oleh sebab itu, untuk menjamin keselamatan Pilot saat uji terbang, perlu dilakukan analisis awal pada kecepatan flutter. Uji terowongan angin selalu dilakukan untuk memvalidasi hasil dari analisis numerikal. Penelitian ini meliputi analisis program NASTRAN pada model separuh sayap pesawat N219 saat uji getaran di tanah. Prediksi kecepatan flutter secara analisis hampir sama dengan hasil uji terowongan angin. Parameter modus struktur yang ditemukan, seperti frekuensi natural, modus getar dan rasio redaman, dapat digunakan untuk analisis parameter flutter sebagai metoda analisis baru.
[The Design and Experiment of Ground Vibration Test of N219 Aircraft Half Wing Model] Flutter phenomena is a critical phenomenon that can be dangerous for aircraft. When an aircraft fly faster until reach flutter speed, the structure will become unstable. Therefore, it is important to conduct preliminary analysis of flutter speed to ensure the safety of Pilot. Wind tunnel test is necessary to be conducted to validate numerical analysis results. This research consist of NASTRAN software analysis of half wing model of N219 aircraft for ground vibration test. The prediction of flutter speed which is obtained from software analysis is similar with the wind tunnel test result. It is found that the modus parameter of structure like natural frequency, modus of vibration and damping ratio can be used on the parameter analysis as a new analysis method.
Evaluasi Kinerja Infrastruktur Transportasi Udara di Ibukota Provinsi
Authors: Rarasati Ayomi D. , Mohammad Imran H. , Latief Yusuf 
Published: September 2017

Adanya penurunan kualitas infrastruktur transportasi di Indonesia menjadikan penelitian mengenai perbedaan kondisi antara kebutuhan dan kemampuan sektor transportasi udara perlu untuk dilaksanakan dalam rangka peningkatan kinerja infrastruktur transportasi udara. Artikel ini menitikberatkan pada analisa jumlah dan pertumbuhan penumpang, jumlah dan pertumbuhan kargo dan juga kebijakan yang diterapkan oleh pemerintah terkait infrastruktur transportasi udara. Berdasarkan analisa multi kriteria yang didapatkan dari data primer dan sekunder, penelitian yang bersifat eksploratif ini akan memberikan gambaran kondisi infrastruktur transportasi udara berdasarkan lalu lintas udara di infrastruktur bandara dan beberapa sudut pandang pemangku kepentingan seperti pemerintah pusat, pemerintah daerah, akademisi dan praktisi. Peningkatan pertumbuhan penumpang merupakan indikator utama kinerja transportasi udara sedangkan pertumbuhan barang hanya sebagai indikator sekunder jika dinilai dari sudut pandang pemerintah pusat maupun pemerintah daerah.
[The Evaluation of Air Transportation Infrastructure Performance in Indonesian Capital Province] The research related to the difference between supply and demand of air transportation due to the decrease in the quality of the transportation infrastructure in Indonesia is needed in order to improve the performance of the air transportation infrastructure. This paper focuses on the analysis of the number and growth of passengers, the number and growth of cargos, and related government policies in air transportation sector. Based on multi-criteria analysis derived from primary and secondary data, this exploratory study will provide the condition of air transportation infrastructure based on the air traffic at the airport and several stakeholders perspectives such as central government, local government, academics and practitioners. The increase in passenger growth is the key indicator of air transportation performance while the cargo growth only serves as the secondary indicator if measured from the viewpoint of the central government and local government.
Glacier disequilibrium in the Convoy Range, Transantarctic Mountains, Antarctica
Authors: Chinn T.J. 
Published: September 2017

Field work for a geological map of the Convoy Range included mapping glaciers, moraines and surficial deposits. A range of glaciological indicators, including supraglacial and other moraines and margin morphology, has been used to assess the present equilibrium of the glaciers. Fields of rafted supraglacial moraine have accumulated over long periods of time at specific low-gradient, low-velocity locations. As the glacier regime changes, the shape of the moraine field distorts, signalling a change in flow pattern. By reversing the ice flow vectors directed at the moraine field, the directions from whence the debris came are shown. Unsorting the contortions of supraglacial moraine fields reveals the nature of the changes in glacier regime. Moraine-field configurations all suggest that local glaciers are expanding in response to higher local precipitation, estimated to have occurred between 2000 and 8000 year BP, most likely coincident with the world-wide “climatic optimum” of about 6000 year BP.Ice-cliff morphology, fresh terminal moraines and boulder trains indicate that larger local glaciers are currently receding from a Holocene maximum, while the margin of the large Mackay Ice Sheet outlet glacier shows no evidence of recent recession and is probably close to its Holocene maximum. In contrast, areas of present snow cover are expanding, superimposing a recent positive balance (decades to hundreds of years), which has yet to reverse a general recession of mid- to high-altitude glaciers. Local hollows in some névé areas imply that glacier flow is not in equilibrium with snow accumulation.
A numerical model of blowing snow around an Antarctic building
Authors: Moore I. , Mobbs S.D. , Ingham D.B. , King J.C. 
Published: September 2017

The accumulation of drifting snow around buildings in regions of severe climate has important implications on their design and location. This paper studies one such building, at a station run by the British Antarctic Survey and located on the Brunt Ice Shelf at the edge of the Antarctic continent. Four previous stations have been built in the area, the buildings of which were designed to become covered in snow and all have been crushed within a few years. The current station, Halley V, consists of three buildings which are all raised from the ice shelf by means of legs. They were designed in such a way that the action of the wind blowing underneath the buildings would keep them-clear of snow.This paper describes a model which predicts the shape and position of drift formation, and then compares the results with those observed at Halley. This model is a first attempt to address the problem and as such the paper can be considered to be a progress report; improvements arc currently being made as part of continuing research. It is found that there is some qualitative agreement and possible reasons for a few quantitative discrepancies are discussed. Both the model and the true data show clearly that the new design is very effective in prolonging the useful life of the buildings.
Validating and improving elevation data of a satellite-image map of Filchner,Ronne Ice Shelf, Antarctica, with Results from ERS-1
Authors: Sievers J. , Doake C.S.M. , Ihde J. , Mantripp D.R. , Pozdeev V.S. , Ritter B. , Schenke H.W. , Thyssen F. , Vaughan D.G. 
Published: September 2017

A satellite-image map with surface-elevation contours of Filchner Ronne Ice Shelf has been published previously as a topographic map. The image map was constructed from a mosaic of 69 Landsat Multispectral Scanner (MSS) images and NOAA AVHRR data. The standard deviation in position in the central part of the mosaic is ±125m. Topographic-glaciologic features were taken from Landsat scenes and represent the best coastline of this region. Surface elevations have been calculated from airborne and ground measurements of either ice thickness (by assuming hydrostatic equilibrium) or barometric pressure. Accuracies vary from ±2 to ±7 m, Oversnow trigonometric levelling in the northeastern part of the ice shelf, tied to sea level at the ice front, has given accuracies of ± 1m. Accuracies reduce to about ±20 m in the grounded ice areas,ERS-I radar-altimeter data over the ice shelf have been processed to give ellipsoidal heights elevation above the ellipsoid), Geoidal reductions have been used to convert these to orthometric heights (elevation above sea level). No tidal corrections have been applied. The overall accuracy of the radar-altimeter-derived elevations is estimated to be better than ±5m. There are noticeable differences from the topographic map in the central part where the radar data indicate a lower surface. However, the maps agree to within the stated error figures.
A comparison of satellite-altimetry and ice-thickness measurements of the Ross Ice Shelf, Antarctica
Authors: Jonathan Bamber , Charles r Bentley 
Published: September 2017

The launch of ERS-l provides coverage, by satellite altimetry, of a large part of the Ross Ice Shelf ineluding areas of input from Byrd Glacier and Ice Streams D and E. Five 35 d repeats of fast-delivery data, comprising approximately 100000 height estimates, have been used to produce a Digital Elevation Model (DEM) of the Ross Icc Shelf north of 81.5° S. Careful filtering of the altimeter data, which removed about 30% of the measurements, ensured that only valid values were used. The data were grldded to produce a DEM with a cell size of 10km. Repeatability of the data was assessed from an analysis of crossing points of ascending and descending tracks. The rms cross-over difference for the ice shelf was 0.94 m. Using the five repeat tracks gave a random error of 0.30 m for an averaged height measurement. Regionally correlated errors in the orbit and geoid add a systematic long wavelength bias of approximately 2m to the final elevation estimate. Two of the latest geoid models, OSU91-A and JGMI, were compared with the available in situ data and hYdrostatic models based on ice and water densities.The altimetry was compared with ice-thickness data from Ross Icc Shelf Geophysical and Glaciological Survey (RIGGS) stations and Scott Polar Research Institute radio-echo-sounding surveys undertaken in the 1970s. Differences between the DEM and heights calculated from ice thicknesses and a standard density -depth equation lie, in general, within the combined measurement errors. There are, however, several areas where this is not the case. Prominent north-south stripes of different ice thickness shown on a RIGGS map apparently do not exist. Low elevations are associated with high-density ice draining from East Antarctic outlet glaciers. The grounding line of Icc Streams D and E and an ice plain behind it are clearly demarcated by the break in surface slope. Grounded ice north of Steershead is also observed
The central part of the Filchner-Ronne Ice Shelf, Antarctica: internal structures revealed by 40MHz monopulse RES
Authors: Blindow N. 
Published: September 2017

About 1200 km of surface-based radio-echo sounding (RES) profiles were measured during the German Antarctic field season 1989-90 on the Filchner Ronne Ice Shelf (FRIS), Antarctica, with a 40 MHz monopulse sounder developed in Münster. In the area investigated, downstream of Doake Ice Rumples and Henry Ice Rise, a basal layer of marine ice up to 400 m thick was found below the meteoric ice, which is less than 100 m thick in some places. High absorption losses and low bottom reflectivity of the basal layer prevented sounding of the total ice thickness, except for areas near the ice edge with strong melting.From common mid-point (CMP) measurements, the velocities of electromagnetic waves in the ice shelf were determined, to obtain precise depths from travel times for airborne and surface-based soundings.The continuous profiling yielded the total ice thickness in the northern part and a variety of internal structures, including lavers in the meteoric and the marine ice, remnants of crevasses, varying reflections of the meteoric-marine interface reflection (MMR). From these data, it is shown that the most-disturbed MMR signatures originate at grounding zones at Doake lee Rumples and at both sides of Henry Ice Rise. The status of the meteoric ice bottom is preserved by the formation of marine ice. Hence, structures remain widely unchanged over 400 km of flow. Internal features that can be correlated on parallel profiles perpendicular to the flow provide an independent means for the construction of flow lines. Even in areas with a smooth MMR, reflection amplitudes show variations by a factor of 2. Their spatial frequency is maximal on profiles prependicular to the now direction. A possible explanation for the amplitude variations is the varying salinity of the top of the marine ice.
Investigating tidal flexure on an ice shelf using kinematic GPS
Authors: Vaughan David G. 
Published: September 2017

The positions of ice-stream grounding zones are uniquely sensitive to changes in the mass balance of the ice sheet. Present methods for locating groundingzone features are either imprecise or require considerable effort in interpretation and so are of little value for change studies. We present a new method which uses the kinematic GPS technique to locate the position of the limit of tidal flexure. The method involves the collection of at least two surface-elevation profiles along the same track through the grounding zone, at different times during the tidal cycle. The elevation profiles obtained coincide upstream of the: limit of flexure but diverge downstream of the limit of flexure. Subtracting the profiles produces a tidal-def1ection profile which shows directly the response of the ice shelf to the tidal forcing.We present two examples of the use of this method, both on Rutford Ice Stream. Antarctica. The first is across the grounding zone and shows that the method is capable of measuring grounding positions to around 200 m precision. The second, taken across an active shear margin, shows a tidal-deflection profile, with an absence of steps that would indicate the presence of fracture planes penetrating from the ice base to sea level.
Effect of ginger extract on angiogenesis using CAM assay
Authors: Bashir Muhammad Farhan , Qadir Muhammad Imran 
Published: September 2017

Angiogenesis performs a critical role in the embryonic growth and several pathological conditions in cancer. This study evaluated the anti-angiogenic properties of the ginger extract using CAM assay. Ginger extract was prepared by methanol. Window was made after 5 days of incubation of eggs and the ginger extract was applied on day 6 at different doses (20, 50, 75 and 150 µL). SPIP software was utilized to investigate the CAM region and diameter of blood vessels. Ginger extract proved anti-angiogenic consequence by decreasing the diameter of CAM of blood vessels. Comparable results were attained at dilution of 150 µL. The anti-angiogenic activity of ginger extract implicates its possible application for diseases where inhibition of blood vessel formation is desired.
Video Clip of Methodology:
7 min 32 sec: Full screen Alternate
SMA Observations of the Hot Molecular Core IRAS 18566+0408
Authors: Silva Andrea , Zhang Qizhou , Sanhueza Patricio , Lu Xing , Beltran Maria T. , Fallscheer Cassandra , Beuther Henrik , Sridharan T. K. , Cesaroni Riccardo 
Published: September 2017

Abstract
We present Submillimeter Array (SMA) observations toward the high-mass star-forming region IRAS 18566+0408. Observations at the 1.3 mm continuum and in several molecular line transitions were performed in the compact (2.″4 angular resolution) and very-extended (∼0.″4 angular resolution) configurations. The continuum emission from the compact configuration shows a dust core of 150 M
⊙, while the very-extended configuration reveals a dense (2.6 × 107 cm−3) and compact (∼4000 au) condensation of 8 M
⊙. We detect 31 molecular transitions from 14 species including CO isotopologues, SO, CH3OH, OCS, and CH3CN. Using the different k-ladders of the CH3CN line, we derive a rotational temperature at the location of the continuum peak of 240 K. The

,

, and

lines reveal a molecular outflow at PA ∼ 135° centered at the continuum peak. The extended

emission has been recovered with the IRAM 30 m telescope observations. Using the combined data set, we derive an outflow mass of 16.8 M
⊙. The chemically rich spectrum and the high rotational temperature confirm that IRAS 18566+0408 is harboring a hot molecular core. We find no clear velocity gradient that could suggest the presence of a rotational disk-like structure, even at the high-resolution observations obtained with the very-extended configuration.