bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fermiology and electron dynamics of trilayer nickelate La4Ni3O10
Authors: Li Haoxiang , Zhou Xiaoqing , Nummy Thomas , Zhang Junjie , Pardo Victor , Pickett Warren E. , Mitchell J. F. , Dessau D. S. 
Published: September 2017

AbstractLayered nickelates have the potential for exotic physics similar to high TC superconducting cuprates as they have similar crystal structures and these transition metals are neighbors in the periodic table. Here we present an angle-resolved photoemission spectroscopy (ARPES) study of the trilayer nickelate La4Ni3O10 revealing its electronic structure and correlations, finding strong resemblances to the cuprates as well as a few key differences. We find a large hole Fermi surface that closely resembles the Fermi surface of optimally hole-doped cuprates, including its $$d_{x^2-y^2}$$

d

x

2

-

y

2

orbital character, hole filling level, and strength of electronic correlations. However, in contrast to cuprates, La4Ni3O10 has no pseudogap in the $$d_{x^2-y^2}$$

d

x

2

-

y

2

band, while it has an extra band of principally $$d_{3z^2-r^2}$$

d

3

z

2

-

r

2

orbital character, which presents a low temperature energy gap. These aspects drive the nickelate physics, with the differences from the cuprate electronic structure potentially shedding light on the origin of superconductivity in the cuprates.
Chemically induced large-gap quantum anomalous Hall insulator states in III-Bi honeycombs
Authors: Crisostomo Christian P. , Huang Zhi-Quan , Hsu Chia-Hsiu , Chuang Feng-Chuan , Lin Hsin , Bansil Arun 
Published: September 2017

AbstractThe search for novel materials with new functionalities and applications potential is continuing to intensify. Quantum anomalous Hall (QAH) effect was recently realized in magnetic topological insulators (TIs) but only at extremely low temperatures. Here, based on our first-principles electronic structure calculations, we predict that chemically functionalized III-Bi honeycombs can support large-gap QAH insulating phases. Specifically, we show that functionalized AlBi and TlBi films harbor QAH insulator phases. GaBi and InBi are identified as semimetals with non-zero Chern number. Remarkably, TlBi exhibits a robust QAH phase with a band gap as large as 466 meV in a buckled honeycomb structure functionalized on one side. Furthermore, the electronic spectrum of a functionalized TlBi nanoribbon with zigzag edge is shown to possess only one chiral edge band crossing the Fermi level within the band gap. Our results suggest that III-Bi honeycombs would provide a new platform for developing potential spintronics applications based on the QAH effect.
Prevalence and predictors of liver disease in HIV-infected children and adolescents
Authors: Pokorska-Śpiewak Maria , Stańska-Perka Aleksandra , Popielska Jolanta , Ołdakowska Agnieszka , Coupland Urszula , Zawadka Konrad , Szczepańska-Putz Małgorzata , Marczyńska Magdalena 
Published: September 2017

AbstractLiver disease in HIV-infected patients may result from the infection itself, antiretroviral treatment or comorbidities. In this study, we analysed liver disease in 79 HIV-infected children and adolescents aged 14.0 ± 5.1 years. All the patients were receiving combination antiretroviral therapy (cART), with a mean duration of 11.5 ± 4.7 years. Six patients (8%) had detectable HIV viral load, and 8/79 (10%) of the participants were coinfected with hepatitis B or C virus (HCV, 6/8 or HBV, 2/8). Liver disease was defined as an elevation of any of the following parameters: alanine or aspartate aminotransferase (ALT and AST), total bilirubin, and gamma glutamyl transferase (GGTP). For the noninvasive evaluation of liver fibrosis, the AST-to-Platelet Ratio Index (APRI) and Fibrosis-4 (FIB-4) were calculated. Liver disease was diagnosed in 20/79 (25%) of the patients, including 13/71 (18%) of participants without coinfection and 7/8 (88%) with coinfection (p < 0.0001). All of the liver markers except bilirubin were significantly higher in the coinfected group. APRI scores indicated significant fibrosis in 5/8 (63%) of patients with coinfection. HBV or HCV coinfection and detectable HIV viral load were independently positively associated with APRI (p = 0.0001, and p = 0.0001) and FIB-4 (p = 0.001, and p = 0.002, respectively). In conclusion, liver disease in HIV-infected children and adolescents results mainly from HBV or HCV coinfection. Effective antiretroviral treatment is protective against hepatic abnormalities.
Time-resolved two-dimensional profiles of electron density and temperature of laser-produced tin plasmas for extreme-ultraviolet lithography light sources
Authors: Tomita Kentaro , Sato Yuta , Tsukiyama Syouichi , Eguchi Toshiaki , Uchino Kiichiro , Kouge Kouichiro , Tomuro Hiroaki , Yanagida Tatsuya , Wada Yasunori , Kunishima Masahito , Soumagne Georg , Kodama Takeshi , Mizoguchi Hakaru , Sunahara Atsushi , Nishihara Katsunobu 
Published: September 2017

AbstractTime-resolved two-dimensional (2D) profiles of electron density (ne) and electron temperature (Te) of extreme ultraviolet (EUV) lithography light source plasmas were obtained from the ion components of collective Thomson scattering (CTS) spectra. The highest EUV conversion efficiency (CE) of 4% from double pulse lasers irradiating a Sn droplet was obtained by changing their delay time. The 2D-CTS results clarified that for the highest CE condition, a hollow-like density profile was formed, i.e., the high density region existed not on the central axis but in a part with a certain radius. The 2D profile of the in-band EUV emissivity (ηEUV) was theoretically calculated using the CTS results and atomic model (Hullac code), which reproduced a directly measured EUV image reasonably well. The CTS results strongly indicated the necessity of optimizing 2D plasma profiles to improve the CE in the future.
Electron tomography and fractal aspects of MoS2 and MoS2/Co spheres
Authors: Ramos Manuel , Galindo-Hernández Félix , Arslan Ilke , Sanders Toby , Domínguez José Manuel 
Published: September 2017

AbstractA study was made by a combination of 3D electron tomography reconstruction methods and N2adsorption for determining the fractal dimension for nanometric MoS2and MoS2/Co catalyst particles.DFTmethods including Neimarke-Kiselev’s method allowed to determine the particle porosity and fractal arrays at the atomic scale for the S-Mo-S(Co) 2D- layers that conform the spherically shaped catalyst particles. A structural and textural correlation was sought by further characterization performed by x-ray Rietveld refinement and Radial Distribution Function (RDF) methods, electron density maps, computational density functional theory methods and nitrogen adsorption methods altogether, for studying the structural and textural features of spherical MoS2and MoS2/Co particles. Neimark-Kiselev’s equations afforded the evaluation of a pore volume variation from 10 to 110 cm3/g by cobalt insertion in the MoS2crystallographic lattice, which induces the formation of cavities and throats in between of less than 29 nm, with a curvature radiusrk < 14.4 nm; typical large needle-like arrays having 20 2D layers units correspond to a model consisting of smooth surfaces within these cavities. DecreasingDP,DB,DIandDMvalues occur when Co atoms are present in the MoS2laminates, which promote the formation of smoother edges and denser surfaces that have an influence on the catalytic properties of the S-Mo-S(Co) system.
CB1 Receptor Activation on VgluT2-Expressing Glutamatergic Neurons Underlies Δ9-Tetrahydrocannabinol (Δ9-THC)-Induced Aversive Effects in Mice
Authors: Han Xiao , He Yi , Bi Guo-Hua , Zhang Hai-Ying , Song Rui , Liu Qing-Rong , Egan Josephine M. , Gardner Eliot L. , Li Jing , Xi Zheng-Xiong 
Published: September 2017

AbstractCannabis can be rewarding or aversive. Cannabis reward is believed to be mediated by activation of cannabinoid CB1 receptors (CB1Rs) on GABAergic neurons that disinhibit dopaminergic neurons in the ventral tegmental area (VTA). However, little is known about the mechanisms underlying cannabis aversion in rodents. In the present study, CB1Rs are found not only on VTA GABAergic neurons, but also on VTA glutamatergic neurons that express vesicular glutamate transporter 2 (VgluT2). We then used Cre-Loxp transgenic technology to selectively delete CB1Rs in VgluT2-expressing glutamatergic neurons (VgluT2-CB1−/−) and Cre-dependent viral vector to express light-sensitive channelrhodopsin-2 into VTA glutamatergic neurons. We found that photoactivation of VTA glutamatergic neurons produced robust intracranial self-stimulation (ICSS) behavior, which was dose-dependently blocked by DA receptor antagonists, but enhanced by cocaine. In contrast, Δ9-tetrahydrocannabinol (Δ9-THC), the major psychoactive component of cannabis, produced dose-dependent conditioned place aversion and a reduction in the above optical ICSS in VgluT2-cre control mice, but not in VgluT2-CB1−/− mice. These findings suggest that activation of CB1Rs in VgluT2-expressing glutamate neurons produces aversive effects that might explain why cannabinoid is not rewarding in rodents and might also account for individual differences in the hedonic effects of cannabis in humans.
Chromophore Renewal and Fluorogen-Binding Tags: A Match Made to Last
Authors: Pimenta Frederico M. , Chiappetta Giovanni , Le Saux Thomas , Vinh Joëlle , Jullien Ludovic , Gautier Arnaud 
Published: September 2017

AbstractFluorogen-binding tags, which activate the fluorescence of a specific chromophore (so-called fluorogen) upon reversible binding, have recently been proposed as a way of reducing photobleaching via fluorogen renewal. However, no generic methodology has been proposed to systematically analyze the photodamage of the fluorogen and the protein tag. Using Y-FAST (Yellow Fluorescence-activating and Absorption-Shifting Tag) as a case study we propose here a generic experimental and theoretical approach to assess how fluorogen renewal reduces the apparent photobleaching rate of a fluorogen-binding tag. Y-FAST has its apparent photobleaching rate greatly reduced by fluorogen renewal and its photostability is mainly limited by oxidation of specific residues in the protein scaffold by reactive oxygen species generated by the bound fluorogen. This study sets the groundwork for the optimization of fluorogenic systems, helping guide rational improvements to their photostability.
The Impact of Self-Reported Sleep on Caesarean Delivery in Women Undergoing Induction of Labour: A Prospective Study
Authors: Teong Aimee Chuin Ai , Diong Annabella Xinhui , Omar Siti Zawiah , Tan Peng Chiong 
Published: September 2017

Abstract216 women admitted for labour induction were recruited to evaluate sleep duration and other sleep measures on Caesarean delivery risk. The Pittsburgh Sleep Quality Index, Berlin (Obstructive Sleep Apnoea (OSA), Epworth Sleepiness Scale, International Restless Leg Syndrome, Insomnia Symptom Questionnaires were applied. Short sleep duration was defined as reported night sleep length in the previous month below the study population median of 6 hours. After binomial analysis, Caesarean delivery after labour induction is associated with short sleep duration (RR 1.8, 95% CI 1.1-2.9, P = 0.018), nulliparity, Bishop Score, prepregnant BMI and birth weight at P < 0.05. After adjustment for nulliparity, Bishop Score, prepregnant BMI and birth weight, short sleep duration remains independently predictive of Caesarean delivery AOR 2.4, 95% CI 1.1-5.0, P = 0.026. Women at high risk for OSA has a non-significant result on binomial analysis, RR 1.6, 95% CI 1.0-2.7, P = 0.073. In a sensitivity analysis which includes OSA in the multivariable logistic regression model, OSA’s predictive effect is attenuated AOR 1.2, 95% CI 0.4-3.2, P = 0.782 whilst short sleep duration remains significant AOR 2.3 95% CI 1.0-5.1, P = 0.039. Other evaluated sleep measures are not predictive of Caesarean delivery.
Ethanol-triggered Lipophagy Requires SQSTM1 in AML12 Hepatic Cells
Authors: Wang Lin , Zhou Jun , Yan Shengmin , Lei Guangsheng , Lee Chao-Hung , Yin Xiao-Ming 
Published: September 2017

AbstractEthanol-induced hepatic lipophagy plays an important cytoprotective role against liver injury, but its mechanism is not fully determined. In the present study, ethanol-induced lipophagy was studied in an immortalized mouse hepatocyte line, AML12. We found that ethanol treatment elevated lipid content in these cells, which could be regulated by autophagy. To determine the potential mechanism, we investigated the role of a key adaptor molecule SQSTM1/p62. SQSTM1 can bind to LC3 on autophagosomes and ubiquitinated molecules on cargos, thus facilitating the autophagic engulfment of the cargo. We found that both LC3 and SQSTM1 could colocalize with lipid droplets (LDs) following ethanol treatment. Colocalization of LC3 with LDs was significantly inhibited by SQSTM1 knockdown, which also reduced ethanol-induced lipid elevation. In addition, increased ubiquitin signals were found to colocalize with SQSTM1 on LDs in response to ethanol. Moreover, the SQSTM1 signal was colocalized with that of perilipin1, a major protein on LDs. Finally, perilipin1 knockdown significantly altered ethanol-induced lipophagy. Taken together, these data support a model in which autophagosomes were directed to the LDs via SQSTM1, which bound to ubiquitinated proteins, possibly including perilipin 1, on LDs. This study provides a potential mechanistic explanation to how ethanol induces lipophagy in hepatocytes.
The impact of long-term oceanic warming on the Antarctic Oscillation in austral winter
Authors: Hao Xin , He Shengping , Wang Huijun , Han Tingting 
Published: September 2017

AbstractIncreasing greenhouse gas concentration and ozone depletion are generally considered two important factors that affect the variability of the Antarctic Oscillation (AAO). Here, we find that the first leading mode of sea surface temperature (SST) variability (rotated empirical orthogonal functions) shows a long-term upward trend from 1901 to 2004 and is closely related to the AAO index that is obtained using the observationally constrained reanalysis data. Further, regressions of the sea level pressure and the 500-hPa geopotential height anomalies, against the principle component associated with the long-term SST anomalies, display a seesaw behavior between the middle and high latitudes of the Southern Hemisphere in austral winter, which is similar to the high polarity of the AAO. The circulation responses to the long-term oceanic warming in three numerical models are consistent with the observed results. This finding suggests that the long-term oceanic warming is partly responsible for the upward trend of the AAO in austral winter. The thermal wind response to the oceanic warming in South Indian and South Atlantic Ocean may be a possible mechanism for this process.
Discovery of a Low Toxicity O-GlcNAc Transferase (OGT) Inhibitor by Structure-based Virtual Screening of Natural Products
Authors: Liu Yubo , Ren Yang , Cao Yu , Huang Huang , Wu Qiong , Li Wenli , Wu Sijin , Zhang Jianing 
Published: September 2017

AbstractO-GlcNAc transferase (OGT) plays an important role in regulating numerous cellular processes through reversible post-translational modification of nuclear and cytoplasmic proteins. However, the function of O-GlcNAcylation is still not well understood. Cell permeable OGT inhibitors are needed to manipulate O-GlcNAcylation levels and clarify the regulatory mechanism of this modification. Here, we report a specific natural-product OGT inhibitor (L01), which was identified from a structure-based virtual screening analysis. L01 inhibited O-GlcNAcylation both in vitro and in cells without significantly altering cell surface glycans. Molecular dynamics and site-directed mutagenesis indicated a new binding mechanism in which L01 could interact with Asn557 near the UDP binding pocket of OGT. This residue may contribute to the specificity of L01. Furthermore, as a specific OGT inhibitor, L01 produced low toxicity in cellular and zebrafish models. The identification of L01 validates structure-based virtual screening approaches for the discovery of OGT inhibitors. L01 can also serve as a chemical tool to further characterize O-GlcNAcylation functions or a new molecular core for structure-activity relationship studies to optimize the biochemical potencies.
Endocytosis and lysosomal degradation of GluA2/3 AMPARs in response to oxygen/glucose deprivation in hippocampal but not cortical neurons
Authors: Koszegi Zsombor , Fiuza Maria , Hanley Jonathan G. 
Published: September 2017

AbstractGlobal cerebral ischemia results in oxygen and glucose deprivation (OGD) and consequent delayed cell death of vulnerable neurons, with hippocampal CA1 neurons more vulnerable than cortical neurons. Most AMPA receptors (AMPARs) are heteromeric complexes of subunits GluA1/GluA2 or GluA2/GluA3, and the presence of GluA2 renders AMPARs Ca2+-impermeable. In hippocampal CA1 neurons, OGD causes the synaptic expression of GluA2-lacking Ca2+-permeable AMPARs, contributing to toxic Ca2+ influx. The loss of synaptic GluA2 is caused by rapid trafficking of GluA2-containing AMPARs from the cell surface, followed by a delayed reduction in GluA2 mRNA expression. We show here that OGD causes endocytosis, lysosomal targeting and consequent degradation of GluA2- and GluA3-containing AMPARs, and that PICK1 is required for both OGD-induced GluA2 endocytosis and lysosomal sorting. Our results further suggest that GluA1-containing AMPARs resist OGD-induced endocytosis. OGD does not cause GluA2 endocytosis in cortical neurons, and we show that PICK1 binding to the endocytic adaptor AP2 is enhanced by OGD in hippocampal, but not cortical neurons. We propose that endocytosis of GluA2/3, caused by a hippocampal-specific increase in PICK1-AP2 interactions, followed by PICK1-dependent lysosomal targeting, are critical events in determining changes in AMPAR subunit composition in the response to ischaemia.
Molecular imaging using an anti-human tissue factor monoclonal antibody in an orthotopic glioma xenograft model
Authors: Takashima Hiroki , Tsuji Atsushi B. , Saga Tsuneo , Yasunaga Masahiro , Koga Yoshikatsu , Kuroda Jun-ichiro , Yano Shigetoshi , Kuratsu Jun-ichi , Matsumura Yasuhiro 
Published: September 2017

AbstractNuclear medicine examinations for imaging gliomas have been introduced into clinical practice to evaluate the grade of malignancy and determine sampling locations for biopsies. However, these modalities have some limitations. Tissue factor (TF) is overexpressed in various types of cancers, including gliomas. We thus generated an anti-human TF monoclonal antibody (mAb) clone 1849. In the present study, immunohistochemistry performed on glioma specimens using anti-TF 1849 mAb showed that TF expression in gliomas increased in proportion to the grade of malignancy based on the World Health Organization (WHO) classification, and TF was remarkably expressed in necrosis and pseudopalisading cells, the histopathological hallmarks of glioblastoma multiforme (GBM). Furthermore, in both fluorescence and single-photon emission computed tomography/computed tomography (SPECT/CT) imaging studies, anti-TF 1849 IgG efficiently accumulated in TF-overexpressing intracranial tumours in mice. Although further investigation is required for a future clinical use of immuno-SPECT with 111In-labelled anti-TF 1849 IgG, the immuno-SPECT may represent a unique imaging modality that can visualize the biological characteristics of gliomas differently from those obtained using the existing imaging modalities and may be useful to evaluate the grade of malignancy and determine sampling locations for biopsies in patients with glioma, particularly GBM.
Hydrogen generation from methanol at near-room temperature
Authors: Shen Yangbin , Zhan Yulu , Li Shuping , Ning Fandi , Du Ying , Huang Yunjie , He Ting , Zhou Xiaochun 
Published: September 2017

We successfully designed an effective strategy to fully convert methanol to hydrogen for at least 1900 min (∼32 h) at near-room temperature.
Supercapacitor‐assisted low dropout regulator technique: a new design approach to achieve high‐efficiency linear DC–DC converters
Authors: Gunawardane Kosala , Kularatna Nihal 
Published: September 2017

Approximate efficiency of a linear regulator is given by the ratio of regulated output voltage to input voltage. Higher voltage difference between the input and the output means a lower efficiency due to heavy losses in the series power semiconductor. Supercapacitor‐assisted low dropout regulator (SCALDO) is an emerging linear DC–DC converter technique, where a supercapacitor (SC) is used to reduce the voltage drop across the series transistor in a linear regulator where the SC acts as a lossless dropper. The circuit operates at a very low frequency decided by the size of the SC. An efficiency multiplication factor such as 1.33, 2, or 3 is achieved depending on the configuration. This study presents the essentials of its generalised theory, few prototype implementations, and a discussion on SCALDO properties. Typical efficiencies of 12–5 and 5–1.2 V linear regulators are around 42 and 24%, respectively. When SCALDO prototypes are built, the authors achieve respective end‐to‐end efficiencies of 79–81 and 58–73%. A loss analysis summary and further developments of the novel technique are also provided, in addition to a discussion to indicate that this is not a variation of the switched capacitor converters.
New inclination changing eclipsing binaries in the Magellanic Clouds
Authors: Juryšek J. , Zasche P. , Wolf M. , Vraštil J. , Vokrouhlický D. , Skarka M. , Liška J. , Janík J. , Zejda M. , Kurfürst P. , Paunzen E. 
Published: September 2017

Context. Multiple stellar systems are unique laboratories for astrophysics. Analysis of their orbital dynamics, if well characterized from their observations, may reveal invaluable information about the physical properties of the participating stars. Unfortunately, there are only a few known and well described multiple systems, this is even more so for systems located outside the Milky Way galaxy. A particularly interesting situation occurs when the inner binary in a compact triple system is eclipsing. This is because the stellar interaction, typically resulting in precession of orbital planes, may be observable as a variation of depth of the eclipses on a long timescale.
Aims. We aim to present a novel method to determine compact triples using publicly available photometric data from large surveys. Here we apply it to eclipsing binaries (EBs) in Magellanic Clouds from OGLE III database. Our tool consists of identifying the cases where the orbital plane of EB evolves in accord with expectations from the interaction with a third star.
Methods. We analyzed light curves (LCs) of 26121 LMC and 6138 SMC EBs with the goal to identify those for which the orbital inclination varies in time. Archival LCs of the selected systems, when complemented by our own observations with Danish 1.54-m telescope, were thoroughly analyzed using the PHOEBE program. This provided physical parameters of components of each system. Time dependence of the EB’s inclination was described using the theory of orbital-plane precession. By observing the parameter-dependence of the precession rate, we were able to constrain the third companion mass and its orbital period around EB.
Results. We identified 58 candidates of new compact triples in Magellanic Clouds. This is the largest published sample of such systems so far. Eight of them were analyzed thoroughly and physical parameters of inner binary were determined together with an estimation of basic characteristics of the third star. Prior to our work, only one such system was well characterized outside the Milky Way galaxy. Therefore, we increased this sample in a significant way. These data may provide important clues about stellar formation mechanisms for objects with different metalicity than found in our galactic neighborhood.