bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Clinical Short-term Outcome of Atorvastatin and Trimetazidine Combination Treatment in Patients with Non-ST Segment Elevation Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention
Authors: Wang Jiangyou , Chen Han , Song Dan , Peng Jian , Su Xi 
Published: November 2016

<p><strong>Background and Objectives: </strong>To investigate the effects of atorvastatin (ATV) and trimetazidine (TMZ) combination treatment in patients with non-ST segment elevation acute coronary syndromes (NSTE-ACS) undergoing percutaneous coronary intervention. <strong></strong></p><p><strong>Subjects and Methods: </strong>A total of 92 patients with NSTE-ACS were randomly divided into the pretreatment with ATV group (80mg 12h before PCI, with a further 20mg every day to 30th days after PCI, n=44) or the pretreatment with ATV (as the ATV group) and TMZ (60mg 30min before PCI, with a further 20mg tid to 30th days after PCI, n=48). Echocardiography was executed and plasma N-terminal pro brain natriuretic peptide (NT-pro-BNP) levels were measured just prior to the PCI and 30th days after PCI. The main end point was a 30-day incidence of major adverse cardiac events.</p><p><strong>Result: </strong>Major adverse cardiac events occurred in 9.1% of patients in the ATV group and 4.2% of those in the ATV+TMZ group (P=0.189). NT-pro-BNP of the two groups were decreased 30th days after PCI, however, NT-pro-BNP in the ATV+TMZ group were significantly lower than those in the ATV group (P&lt;0.05). Cardiac function in NSTE-ACS patients, as reflected by the increased LVEF, FS as well as decreased LVEDd (P&lt;0.05) in all groups at 30 days after intervention, but cardiac function parameters were more obviously improved in the group administered with ATV+TMZ (p&lt;0.05).</p><p><strong>Conclusion: </strong>Short-term pretreatment with the combination of ATV and TMZ administration prior to PCI can prominently decrease NT-pro-BNP and improve cardiac function compared to a single administration of the ATV. </p>
Ebstein’s anomaly and Left Ventricular Non Compaction Cardiomyopathy: a Not So Unusual Association
Authors: Andreini Daniele , Pontone Gianluca , Mushtaq Saima , Muratori Emanuela , Guglielmo Marco , Conte Edoardo , Carita' Patrizia , Pepi Mauro 
Published: November 2016

<p align="JUSTIFY"><span lang="en-GB">Left ventricular n</span><span lang="en-GB">on-compaction (LVNC) is a rare congenital cardiomyopathy. </span><span lang="en-US">It is thought to be a congenital arrest of endomyocardial embryogenesis in utero</span><span lang="en-US"><strong>.</strong></span><span lang="en-US"> It has been reported the association with</span><span lang="en-US"> other cardiac abnormalities. </span><span lang="en-GB">We pre</span><span lang="en-GB">sented two cases of association of LVNC and Ebstein's anomaly. </span>The cardiac magnetic resonance (CMR) allows a comprehensive evaluation of associated findings. All patients with Ebstein’s anomaly should be carefully evaluated for LVNC. The prompt identification of myocardial non compaction is important because of its high mortality due to progressive heart failure, tromboembolism and malignant arrhythmias</p>
Vazio Existencial: um fundo sem fundo
Authors: Pichler Nadir Antonio 
Published: November 2016

Resumo: o homem, dentre todos os seres, possui consciência de sua existência, pois é um ser inserido no mundo, com o mundo e para o mundo. Por isso ele tem consciência de sua potencialidade, finitude e perfectibilidade. E o vazio existencial é decorrente dessa condição natural. Assim, o objetivo do artigo, de natureza bibliográfica, é refletir sobre o vazio existencial humano, decorrente de sua condição de ser no mundo. E quanto mais o homem procura realizar-se, principalmente pela busca de bens materiais e efêmeros, mais ele mergulha no vazio. Ora, as ciências humanas, como a filosofia, a psicologia e a teologia, conseguem amenizar esse fundo sem fundo, mas jamais realizá-lo na sua plenitude de ser existencial, porque o homem é um ser inconcluso.
Palavras-chave: Vazio existencial. Homem. Felicidade. Finitude.
Deus, Felicidade Plena do Ser Humano: o conceito de Deus na Teologia de Andréa Torres Queiruga
Authors: Motta Ronaldo Silveira , Miranda Mário De França 
Published: November 2016

Resumo: o propósito deste trabalho é apresentar como Queiruga vê a face de Deus, com um olhar crítico à visão individual, temporal, sem o crivo da visão de Jesus Cristo. Esse novo conceito de Deus não é excludente, mas apresentado como um Deus para todos, sendo o que ele diz ser: um Deus de amor.
Palavras-chave: Imagem de Deus. Modernidade. Experiência de Abbá. Realização existencial.
Legal norms, Profesional values, and practical ethics in local government: Elderly care in Latvia, Lithuania, and Norway
Authors: Kjørstad Monica , Koht Harald S. , Reinholde Iveta , Tufte Geir Conrad 
Published: November 2016

This article reports findings from a comparative study of the influence of values and norms on the delivery of administrative and professional services in the public sector at the local gov-ernment level in three selected countries in the Baltic Sea Region, Latvia, Lithuania, and Norway. The research concerns the criteria that professional welfare and health professionals apply in individual cases whenever they are expected to make high-quality judgments regard-ing the care of older people. The research question seeks to ascertain whether there are signif-icant differences with regard to the effect of formal rules and norms on the effort to arrive at good solutions in providing public services in three democracies, one long-established and two recent.
The results of this study show that in making their decisions, professionals in all countries emphasize the necessity of considering a broad range of legal and professional norms. For all respondents these considerations – in varying degrees of intensity – rank ahead of economic and administrative concerns.
BIOMINERALOGICAL INVESTIGATION OF APATITE PIEZOELECTRICITY
Authors: Pawlikowski M. 
Published: November 2016

Investigation of apatite piezoelectricity was conducted in order to assess piezoelectric properties of bone. In the first stage, mineralogical analysis of different apatite crystals, regarding their purity and fitness for the experiments was performed. After the crystals had been chosen, 0.8 mm-thick plates were cut, perpendicular and parallel to the crystallographic Z axis. The plates were then polished and dusted with gold. Electrodes were attached to the opposite surfaces of the plates with conductive glue. So prepared plates were hooked up to the EEG machine used for measuring electrical activity in the brain. The plates were then gently tapped to observe and register currents generated in them. Acquired data was processed by subtracting from the resulting graphs those generated by a hand movement, without tapping the plate. Results indicate that apatite plates have weak piezoelectric properties. Observed phenomenon may be translated to bone apatite, which would explain, at least partially, piezoelectric properties of bone. Acquired results suggest that there is a relation between the mechanical workload of bones (bone apatite) and theirelectrical properties. Considering the massive internal surface of bones, they may be treated as a kind of internal “antenna” reacting not only to mechanical stimuli, but to changes in electromagnetic field as well. Observed phenomena no doubt significantly influence the biological processes occurring in bones and the whole human body.
Pathogenic Variants in Complement Genes and Risk of Atypical Hemolytic Uremic Syndrome Relapse after Eculizumab Discontinuation
Authors: Fakhouri Fadi , Fila Marc , Provôt François , Delmas Yahsou , Barbet Christelle , Châtelet Valérie , Rafat Cédric , Cailliez Mathilde , Hogan Julien , Servais Aude , Karras Alexandre , Makdassi Raifah , Louillet Feriell , Coindre Jean-Philippe , Rondeau Eric , Loirat Chantal , Frémeaux-Bacchi Véronique 
Published: November 2016

Background and objectives
The complement inhibitor eculizumab has dramatically improved the outcome of atypical hemolytic uremic syndrome. However, the optimal duration of eculizumab treatment in atypical hemolytic uremic syndrome remains debated. We report on the French atypical hemolytic uremic syndrome working group’s first 2-year experience with eculizumab discontinuation in patients with atypical hemolytic uremic syndrome.

Design, setting, participants & measurements
Using the French atypical hemolytic uremic syndrome registry database, we retrospectively identified all dialysis–free patients with atypical hemolytic uremic syndrome who discontinued eculizumab between 2010 and 2014 and reviewed their relevant clinical and biologic data. The decision to discontinue eculizumab was made by the clinician in charge of the patient. All patients were closely monitored by regular urine dipsticks and blood tests. Eculizumab was rapidly (24–48 hours) restarted in case of relapse.

Results
Among 108 patients treated with eculizumab, 38 patients (nine children and 29 adults) discontinued eculizumab (median treatment duration of 17.5 months). Twenty-one patients (55%) carried novel or rare complement genes variants. Renal recovery under eculizumab was equally good in patients with and those without complement gene variants detected. After a median follow-up of 22 months, 12 patients (31%) experienced atypical hemolytic uremic syndrome relapse. Eight of 11 patients (72%) with complement factor H variants, four of eight patients (50%) with membrane cofactor protein variants, and zero of 16 patients with no rare variant detected relapsed. In relapsing patients, early reintroduction (≤48 hours) of eculizumab led to rapid (<7 days) hematologic remission and a return of serum creatinine to baseline level in a median time of 26 days. At last follow-up, renal function remained unchanged in nonrelapsing and relapsing patients compared with baseline values before eculizumab discontinuation.

Conclusions
Pathogenic variants in complement genes were associated with higher risk of atypical hemolytic uremic syndrome relapse after eculizumab discontinuation. Prospective studies are needed to identify biomarkers predictive of relapse and determine the best strategy of retreatment in relapsing patients.
Marginal Adaptation and Quality of Interfaces in Lithium Disilicate Crowns — Influence of Manufacturing and Cementation Techniques
Authors: Melo Freire CA , Borges GA , Caldas DBM , Santos RS , Ignácio SA , Mazur RF 
Published: November 2016

SUMMARY
Purpose: To evaluate the cement line thickness and the interface quality in milled or injected lithium disilicate ceramic restorations and their influence on marginal adaptation using different cement types and different adhesive cementation techniques.
Methods and Materials: Sixty-four bovine teeth were prepared for full crown restoration (7.0±0.5 mm in height, 8.0 mm in cervical diameter, and 4.2 mm in incisal diameter) and were divided into two groups: CAD/CAM automation technology, IPS e.max CAD (CAD), and isostatic injection by heat technology, IPS e.max Press (PRESS). RelyX ARC (ARC) and RelyX U200 resin cements were used as luting agents in two activation methods: initial self-activation and light pre-activation for one second (tack-cure). Next, the specimens were stored in distilled water at 23°C ± 2°C for 72 hours. The cement line thickness was measured in micrometers, and the interface quality received scores according to the characteristics and sealing aspects. The evaluations were performed with an optical microscope, and scanning electron microscope images were presented to demonstrate the various features found in the cement line. For the cement line thickness, data were analyzed with three-way analysis of variance (ANOVA) and the Games-Howell test (α=0.05). For the variable interface quality, the data were analyzed with the Mann-Whitney U-test, the Kruskal-Wallis test, and multiple comparisons nonparametric Dunn test (α=0.05).
Results: The ANOVA presented statistical differences among the ceramic restoration manufacturing methods as well as a significant interaction between the manufacturing methods and types of cement (p&lt;0.05). The U200 presented lower cement line thickness values when compared to the ARC with both cementation techniques (p&lt;0.05). With regard to the interface quality, the Mann-Whitney U-test and the Kruskal-Wallis test demonstrated statistical differences between the ceramic restoration manufacturing methods and cementation techniques. The PRESS ceramics obtained lower scores than did the CAD ceramics when using ARC cement (p&lt;0.05).
Conclusions: Milled restorations cemented with self-adhesive resin cement resulted in a thinner cement line that is statistically different from that of CAD or pressed ceramics cemented with resin cement with adhesive application. No difference between one-second tack-cure and self-activation was noted.
Shear Bond Strength and Tooth-Composite Interaction With Self-Adhering Flowable Composites
Authors: Brueckner C , Schneider H , Haak R 
Published: November 2016

SUMMARY
Purpose: To evaluate the tooth-composite interaction (A) and shear bond strength (SBS; B) of self-adhering flowables.
Methods and Materials: (A) Thirty-two human molars with one Class V cavity were restored with Vertise Flow (VF), Fusio Liquid Dentin (FLD), an experimental self-adhering flowable (EF), or Adper Prompt-L-Pop/Filtek Supreme XT Flowable (PLP). Teeth were prepared according to laboratory standard and stored in water (24 hours, 37°C). Microleakage (ML; percentage interface length at enamel [E]/dentin [D]) and tooth-composite interaction were investigated. (B) The buccal surface of 160 embedded human molars was abraded to expose an enamel/dentin area of diameter ≥3 mm. Composite specimens were produced on enamel/dentin with VF, FLD, EF, or PLP. Prior to loading, 80 samples were water stored (24 hours, 37°C) and 80 thermocycled (5°C-55°C, 1500 cycles). The SBS was measured, and failure modes were classified by scanning electron microscopy.
Statistics: Kruskal-Wallis, Mann-Whitney U, and Fisher exact tests were performed (α=0.05).
Results: (A) At enamel margins, EF and VF showed significantly lower ML than did FLD and PLP (pi≤0.009; 81%-89%); in dentin, lower values resulted with FLD and VF compared with PLP and EF (pi≤0.01; 77%-94%). Adhesive tags at E were consistently verifiable with EF and VF but irregularly with FLD and PLP. At D, tags were detectable with all systems. (B) In all groups, SBS decreased by up to 97% after thermocycling. It was generally diminished with self-adhering flowables (E: 50%-98%, D: 59%-98%; pi&lt;0.02). More cohesive defects were observed with PLP (pi&lt;0.009).
Conclusion: Tooth-composite morphology and bond strength indicate that the clinical use of self-adhering flowables must be pursued cautiously.
Margin Integrity and Secondary Caries of Lined or Non-lined Composite and Glass Hybrid Restorations After Selective Excavation In Vitro
Authors: Schwendicke F , Kniess JLM , Paris S , Blunck U 
Published: November 2016

SUMMARY
Objectives: For deep carious lesions, selective carious tissue removal (leaving soft dentin close to the pulp) is suggested. Afterward, different restoration materials, such as resin composites or glass hybrids (GHs), can be placed. Many dentists also apply setting or non-setting calcium hydroxide liners before restoration. We compared margin integrity and susceptibility for secondary caries in differently restored premolars in vitro.
Methods: In 48 extracted human premolars, artificial residual lesions were induced on pulpo-axial walls of standardized cavities. Teeth were restored using a GH (Equia Forte) or adhesively placed resin composite restoration (OptiBond FL and Tetric EvoCeram) without any liner (RC), resin composite restoration with a non-setting calcium hydroxide liner (RC_NCH), or resin composite restoration with a setting calcium hydroxide liner (RC_SCH). After thermomechanical cycling, groups (n=12) were compared regarding their gingivocervical margin integrity (proportion of irregularities, microgaps, gaps &gt;5 μm, overhangs). Teeth were then submitted to a continuous culture Lactobacillus rhamnosus biofilm model. After 14 days, bacterial numbers in biofilms, along tooth-restoration margins and mineral loss (ΔZ) of secondary lesions, were determined.
Results: GH and RC_NCH showed significantly higher proportions of irregularities than RC and RC_SCH (p&lt;0.05/Mann-Whitney). GH also showed significantly more gaps than alternative restorations (p&lt;0.05). Bacterial numbers and ΔZ did not differ significantly between groups (p&gt;0.05).
Conclusions: GH and composites lined with non-setting calcium hydroxide showed reduced margin integrity compared with non-lined composites or composites lined with setting calcium hydroxide. This did not increase susceptibility for secondary caries.
Quelle reconstruction dans la campagne alsacienne au lendemain des guerres du XVIIe siècle ?
Authors: Boehler Jean-Michel 
Published: November 2016

Mise à la mode historiographique au lendemain de la Seconde Guerre mondiale, la problématique de la « reconstruction » porte avant tout sur les réparations matérielles. Celle qui suit les guerres du XVIIe siècle, entre 1648 et les années 1720, tient compte à la fois des spécificités de la campagne alsacienne et du type de guerre pratiqué (rebondissement des conflits, dévastations et épuisement des ressources). Multiforme, elle est d’abord une reconstruction démographique, dans laquelle l’immigration tient une large part, le repeuplement bénéficiant, de la part du roi ou des seigneurs territoriaux, d’édits de défrichement particulièrement avantageux. Sur le plan économique, elle se solde souvent par un retour à l’âge d’or, mythique et idéalisé, des temps anciens : plus apparents que réels, les progrès qu’elle induit seront en effet tardifs (XVIIIe siècle) et relèveront souvent d’un simple rattrapage. De même, l’indispensable reconstruction religieuse et morale renoue également avec les valeurs traditionnelles et les usages séculaires. La reconstruction revêt ensuite, de la part des grands propriétaires fonciers, l’apparence d’une patiente reconstitution des droits face à l’usurpation des biens « caducs » et à l’instrumentalisation d’une emphytéose fréquemment usurpée par les exploitants. Sur le plan politique enfin, elle renforce l’autorité des princes territoriaux face au pouvoir souverain de l’empereur ou du roi.
Émile Salomon (1833-1913)
Authors: Umbrecht Véronique 
Published: November 2016

Né à Strasbourg d’un père allemand et d’une mère alsacienne, Émile Salomon suit une double formation d’architecte à Paris à l’école des Beaux-arts de Paris puis à l’Akademie der bildenden Künste de Munich. Il contribue à la reconstruction de plusieurs quartiers après la guerre de 1870. Architecte attitré de la Fondation Saint-Thomas, il est chargé de redessiner le quartier du Temple Neuf, dévasté par les bombardements. Les dégâts de la guerre et la nécessité de reconstruire au plus vite incitent la municipalité et les particuliers à rénover un grand nombre de bâtiments. C’est à cette époque que le Consistoire protestant confie à Émile Salomon la transformation du quartier Saint-Thomas. Une nouvelle rue est percée, donnant un accès plus aisé à l’église Saint-Thomas. L’engagement d’Émile Salomon dans la défense et la valorisation du patrimoine alsacien ancré entre l’héritage français et allemand, ont nourri ses réflexions sur son art et lui ont permis d’affirmer un style spécifique, libre des pressions de la « germanisation » insufflée par les autorités allemandes.
L’épreuve de la reconstruction industrielle dans le Haut-Rhin après la Grande Guerre
Authors: Wisniewski Clément 
Published: November 2016

Les deux départements alsaciens ne sont pas touchés par la guerre de la même manière. Alors que le Bas-Rhin occupe une position plus en retrait, le Haut-Rhin est traversé par la ligne de front. Les combats demeurent toutefois cantonnés sur les hauteurs vosgiennes, si bien qu’une partie de l’industrie haut-rhinoise installée dans les différentes vallées est détruite par les combats. D’autres usines sont également affectées par les aléas de la guerre : productions restreintes, chômage technique en raison des pénuries de matières premières, réquisitions de leur outillage… Pour faire face à cette multitude de dommages de guerre, une législation particulière résultant du droit allemand, français et du traité de Versailles, ainsi que des services administratifs propres à l’Alsace se mettent en place pour accompagner la reconstruction après-guerre. Toutefois, malgré une législation qui vise à favoriser leur réintégration dans l’économie nationale, les industriels alsaciens se trouvent pénalisés par des délais d’attente supérieurs aux autres régions dévastées pour le versement de leurs indemnités, prolongeant ainsi les difficultés causées par la Grande Guerre.
Reconstituer et reconstruire l’habitat rural après la Première Guerre mondiale : l’exemple des communes de la haute vallée de Munster (1919 - vers 1930)
Authors: Raimbault Jérôme 
Published: November 2016

Au cours de la première année de la Grande Guerre, huit des neuf communes implantées en amont de la ville de Munster (Haut-Rhin), situées alors de part et d’autre de la ligne de front, sont anéanties dans des proportions supérieures à 90%. Plus d’une décennie est nécessaire pour mener à terme l’immense chantier de reconstitution de leur territoire et de reconstruction de leur habitat rural. Au sein d’un département nouvellement recouvré par la France, le service de la Reconstitution en Haute-Alsace va œuvrer dès 1919 au dédommagement des sinistrés et au relèvement des ruines. Il est chargé de l’application des lois prises par le gouvernement : loi sur les dommages de guerre (nommée aussi « Charte des sinistrés ») du 17 avril 1919 et loi sur les sociétés coopératives de reconstruction du 15 août 1920. Palliant les défaillances initiales de l’État, ces sociétés vont à partir de 1921 superviser et assurer la grande majorité des travaux de reconstruction des maisons et des fermes, en coordonnant l’activité des hommes de l’art, architectes et entrepreneurs. Cette entreprise d’une ampleur inédite donne la possibilité aux architectes de repenser les formes d’un habitat dont la sobriété est caractéristique de la moyenne montagne vosgienne. Prenant le dessus sur le courant moderniste, le courant régionaliste anime les architectes de la Reconstruction. Ceux-ci font renaître un habitat qui réinvestit les volumes et les distributions anciens et dont la modernité se manifeste par le choix des matériaux.