bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conformal higher‐order remeshing schemes for implicitly defined interface problems
Authors: Omerović Samir , Fries Thomas‐Peter 
Published: May 2016

SummaryA new higher‐order accurate method is proposed that combines the advantages of the classical p‐version of the FEM on body‐fitted meshes with embedded domain methods. A background mesh composed by higher‐order Lagrange elements is used. Boundaries and interfaces are described implicitly by the level set method and are within elements. In the elements cut by the boundaries or interfaces, an automatic decomposition into higher‐order accurate sub‐elements is realized. Therefore, the zero level sets are detected and meshed in a first step, which is called reconstruction. Then, based on the topological situation in the cut element, higher‐order sub‐elements are mapped to the two sides of the boundary or interface. The quality of the reconstruction and the mapping largely determines the properties of the resulting, automatically generated conforming mesh. It is found that optimal convergence rates are possible although the resulting sub‐elements are not always well‐shaped. Copyright © 2016 John Wiley & Sons, Ltd.
Can Social–Emotional Learning Reduce School Dropout in Developing Countries?
Authors: Wang Huan , Chu James , Loyalka Prashant , Xin Tao , Shi Yaojiang , Qu Qinghe , Yang Chu 
Published: May 2016

AbstractAn alarming number of students drop out of junior high school in developing countries. In this study, we examine the impacts of providing a social–emotional learning (SEL) program on the dropout behavior and learning anxiety of students in the first two years of junior high. We do so by analyzing data from a randomized controlled trial involving 70 junior high schools and 7,495 students in rural China. After eight months, the SEL program reduces dropout by 1.6 percentage points and decreases learning anxiety by 2.3 percentage points. Effects are no longer statistically different from zero after 15 months, perhaps due to decreasing student interest in the program. However, we do find that the program reduces dropout among students at high risk of dropping out (older students and students with friends who have already dropped out), both after eight and 15 months of exposure to the SEL program.
Coombs Positive Thrombotic Thrombocytopenic Purpura in a Male Pediatric Patient: An Urgent Diagnostic Challenge
Authors: Zenno Anna , Richardson Matthew 
Published: May 2016

Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy often caused by deficiency of von Willebrand (vW) factor cleaving protease, ADAMTS‐13, leading to large vW multimers and intravascular platelet aggregation. Hemolysis in TTP is mechanical and nonimmune mediated, thus Coombs testing is usually negative. We report a case of an adolescent with thrombocytopenia and Coombs positive anemia, diagnosed with Evans syndrome, but ultimately found to have TTP. TTP should be considered in children with thrombocytopenia and Coombs positive anemia who are refractory to steroids or develop signs of microangiopathy. Recognition of this presentation can lead to life‐saving treatment with plasma exchange.
Early Discharge of Neutropenic Pediatric Oncology Patients Admitted With Fever
Authors: Villanueva Melanie A. , August Keith J. 
Published: May 2016

BackgroundFever and neutropenia (FN) is a common complication of pediatric oncology therapy and accounts for a large number of hospital admissions. Standard therapy for FN includes hospital admission and empiric antibiotics. Strict adherence to this practice leads to prolonged hospitalizations that may be unnecessary for patients at low risk of having an underlying significant infection.ProcedureChildren admitted with FN could be discharged after a minimum of 48 hr with no further antibiotic therapy once they had been afebrile for 24 hr with negative blood cultures from initial presentation, regardless of their neutrophil count. We performed a retrospective review with regard to readmissions and subsequent documented infections in FN patients discharged with an ANC of ≤500 cells/mm3.ResultsThere were 299 FN admissions in 188 patients who were discharged prior to achieving an ANC of ≥500 cells/mm3. Readmission to the hospital during the same period of neutropenia occurred in 50 cases (16.7%) with 27 infections diagnosed in 21 patients. Patients discharged with an ANC of ≤100 cells/mm3 (odds ratio 3.7) and patients with acute lymphoblastic leukemia (odds ratio 2.6) were more likely to be readmitted for fever. All patients that developed a significant infection had an ANC of ≤100 cells/mm3 at admission and discharge. In patients that developed a significant infection, only one required admission to the intensive care unit with no deaths.ConclusionsThe practice of discharging patients with persistent neutropenia who are afebrile with negative blood cultures produces acceptable rates of readmission and subsequent infection and does not lead to increased morbidity and mortality.
The expanding field of cooperative initiatives for decarbonization: a review of five databases
Authors: Widerberg Oscar , Stripple Johannes 
Published: May 2016

Climate governance beyond the United Nations Framework Convention on Climate Change (UNFCCC)—including countries, companies, civil society, and international organizations, forming cooperative initiatives—is increasingly framed as complementing, supporting, and even substituting the multilateral negotiations. Cooperative initiatives activating nonstate actors could help bridging the ‘ambition gap’ between governmental greenhouse gas mitigation pledges and the decarbonization pathway needed to halt global warming at 2°C. But what do we know about the performance of cooperative initiatives and their participants? We examine the content of five databases aiming to capture the emerging field of cooperative initiatives and assess whether it is possible to measure the performance of cooperative initiatives based on current data. Overall, we find a substantial lack of ex post data for measuring performance. Available studies either focus on nonemission‐related qualitative variables and characteristics of cooperative initiatives such as governance function, participants composition, and thematic areas, or use quantitative modeling approaches to estimate their potential impact. Consequently, we currently lack information to assess how existing initiatives perform in relation to the socio‐technical systems they are intended to intervene in, or how initiatives align, scale‐up, and form low‐carbon pathways. Given the increasingly important role and legitimacy attributed to cooperative initiatives in addressing climate change, we argue that focusing more on gathering ex post data, improving exchange between academic and policy‐oriented work, and developing assessment methods accommodating diversity in terms of function, goal, and output, are needed to understand the performance of climate governance beyond the UNFCCC. WIREs Clim Change 2016, 7:486–500. doi: 10.1002/wcc.396This article is categorized under:

Policy and Governance > Multilevel and Transnational Climate Change Governance
Effect of long-term ingestion of weakly oxidised flaxseed oil on biomarkers of oxidative stress in LDL-receptor knockout mice
Authors: Nogueira M. S. , Kessuane M. C. , Lobo Ladd A. A. B. , Lobo Ladd F. V. , Cogliati B. , Castro I. A. 
Published: May 2016

AbstractThe effect of oxidised fatty acids on atherosclerosis progression is controversial. Thus, our objective was to evaluate the effect of long-term consumption of weakly oxidised PUFA from flaxseed oil on oxidative stress biomarkers of LDL-receptor(−/−)mice. To test our hypothesis, mice were separated into three groups. The first group received a high-fat diet containing fresh flaxseed oil (CONT−), the second was fed the same diet prepared using heated flaxseed oil (OXID), and the third group received the same diet containing fresh flaxseed oil and had diabetes induced by streptozotocin (CONT+). Oxidative stress, aortic parameters and non-alcoholic fatty liver disease were assessed. After 3 months, plasma lipid profile, glucose levels, body weight, energy intake and dietary intake did not differ among groups. Likewise, oxidative stress, plasma malondialdehyde (MDA), hepatic MDA expressed as nmol/mg portion (ptn) and antioxidant enzymes did not differ among the groups. Hepatic linoleic acid,α-linolenic acid, arachidonic acid and EPA acid declined in the OXID and CONT+ groups. Aortic wall thickness, lumen and diameter increased only in the OXID group. OXID and CONT+ groups exhibited higher concentrations of MDA, expressed as μmol/mg ptn per %PUFA, when compared with the CONT− group. Our results suggest that ingestion of oxidised flaxseed oil increases hepatic MDA concentration and is potentially pro-atherogenic. In addition, the mean MDA value observed in all groups was similar to those reported in other studies that used xenobiotics as oxidative stress inducers. Thus, the diet applied in this study represents an interesting model for further research involving antioxidants.
Charitable organisations, the Great Recession and the Age of Austerity: Longitudinal Evidence for England and Wales
Authors: CLIFFORD DAVID 
Published: May 2016

AbstractThere has been extensive concern about the effect of recession and of subsequent public spending austerity on the voluntary sector – but a lack of comprehensive sector-wide data to examine this empirically. We construct a unique longitudinal dataset, which follows through time the population of charitable organisations in England and Wales since 1999, and assess the impact of recession and austerity by placing organisations’ recent annual income within the context of longer-term trends. The results reveal the scale of the impact on charities’ incomes for the first time: since 2008 median real annual growth in income has been negative for six consecutive years, leading to sizeable cumulative real income decline over the period. Mid-sized charities, and those in more deprived local areas, have been most significantly affected, consistent with concerns about a ‘hollowing out’ of the charitable sector and about the uneven impact of austerity. However, there has also been considerable variation in the fortunes of charities working in different fields of activity. The analysis in this paper helps to widen our perspective on the implications of the Great Recession and of public spending austerity for social policy.
The effect of zinc supplementation on body composition and hormone levels related to adiposity among children: a systematic review
Authors: Gunanti Inong R , Al-Mamun Abdullah , Schubert Lisa , Long Kurt Z 
Published: May 2016

AbstractObjectiveTo provide a comprehensive synthesis of the effects of Zn supplementation on childhood body composition and adiposity-related hormone levels.DesignFive electronic databases were searched for randomized controlled trials of Zn supplementation studies published before 28 February 2015. No statistical pooling of results was carried out due to diversity in study designs.SettingCommunity- or hospital-based, from fourteen developing and developed countries.SubjectsChildren and adolescents aged 0 to 10 years.ResultsSeven of the fourteen studies reported an overall or subgroup effect of Zn supplementation on at least one parameter of body composition, when determined by anthropometric measurements (increased mid upper-arm circumference, triceps skinfold, subscapular skinfold and mid upper-arm muscle area, and decreased BMI). Three out of the fourteen studies reported increased mean value of total body water estimated by bio-impedance analysis and increased fat-free mass estimated by dual energy X-ray absorptiometry and by total body water. Zn supplementation was associated with increased fat-free mass among stunted children. One study found supplementation decreased leptin and insulin concentrations.ConclusionsDue to the use of anthropometry when determining body composition, a majority of the studies could not accurately address whether alterations in the fat and/or fat-free mass components of the body were responsible for the observed changes in body composition. The effect of Zn supplementation on body composition is not consistent but may modify fat-free mass among children with pre-existing growth failure.
Grounded objects. Archaeology and speculative realism
Authors: Edgeworth Matt 
Published: May 2016

AbstractThe philosophical movement known as speculative realism (SR) has much in common with archaeology. As well as a shared concern with objects and with time, both have orientations towards an external reality that exists (or existed) outside the domain of human knowledge. This paper explores overlaps and commonalities in these two very different types of investigation. Proceeding from an archaeological perspective, it critically assesses the relevance of some of the key ideas of SR for archaeology, while also looking at ways in which these can be challenged, honed, adapted and transformed through encounters with archaeological objects. It asks the question, what can archaeology usefully contribute to the SR project?
Factor endowments, the rule of law and structural inequality
Authors: BENNETT DANIEL L. , NIKOLAEV BORIS 
Published: May 2016

AbstractThis paper provides an empirical test of the Engerman–Sokoloff hypothesis that factor endowments influenced the development of the rule of law, which in turn has perpetuated income inequality. Using a measure of the suitability of land for growing wheat relative to sugarcane as an instrument for the rule of law, as measured by area 2 of the Economic Freedom of the World index, we estimate the potential causal impact of the rule of law on the long-run net income inequality. Conditioning on geography, ethnolinguistic fractionalization and legal tradition, the rule of law exerts a negative impact on inequality that is both economically and statistically significant. The results are robust to additional control variables, two alternative measures of the rule of law, an alternative instrumental variable and the exclusion of strategic country samples and outliers.
Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling
Authors: Morin-Poulard Ismaël , Sharma Anurag , Louradour Isabelle , Vanzo Nathalie , Vincent Alain , Crozatier Michèle 
Published: May 2016

AbstractSelf-renewal and differentiation of mammalian haematopoietic stem cells (HSCs) are controlled by a specialized microenvironment called ‘the niche’. In the bone marrow, HSCs receive signals from both the endosteal and vascular niches. The posterior signalling centre (PSC) of the larval Drosophila haematopoietic organ, the lymph gland, regulates blood cell differentiation under normal conditions and also plays a key role in controlling haematopoiesis under immune challenge. Here we report that the Drosophila vascular system also contributes to the lymph gland homoeostasis. Vascular cells produce Slit that activates Robo receptors in the PSC. Robo activation controls proliferation and clustering of PSC cells by regulating Myc, and small GTPase and DE-cadherin activity, respectively. These findings reveal that signals from the vascular system contribute to regulating the rate of blood cell differentiation via the regulation of PSC morphology.
Bioactivity of 2′-deoxyinosine-incorporated aptamer AS1411
Authors: Fan Xinmeng , Sun Lidan , Wu Yun , Zhang Lihe , Yang Zhenjun 
Published: May 2016

AbstractAptamers can be chemically modified to enhance nuclease resistance and increase target affinity. In this study, we performed chemical modification of 2′-deoxyinosine in AS1411, an anti-proliferative G-rich oligodeoxynucleotide aptamer, which binds selectively to the nucleolin protein. Its function was augmented when 2′-deoxyinosine was incorporated at positions 12, 13, 15, and 24 of AS1411, respectively. In addition, double incorporation of 2′-deoxyinosine at positions 12 and 24 (FAN-1224dI), 13 and 24 (FAN-1324dI), and 15 and 24 (FAN-1524dI) promoted G-quartet formation, as well as inhibition of DNA replication and tumor cell growth, and induced S-phase cell cycle arrest. In further animal experiments, FAN-1224dI, FAN-1324dI and FAN-1524dI resulted in enhanced treatment effects than AS1411 alone. These results suggested that the position and number of modification substituents in AS1411 are critical parameters to improve the diagnostic and therapeutic function of the aptamer. Structural investigations of the FAN-1524dI/nucleolin complex structure, using molecular dynamics simulation, revealed the critical interactions involving nucleolin and 2′-dI incorporated AS1411 compared with AS1411 alone. These findings augment understanding of the role of 2′-deoxyinosine moieties in interactive binding processes.
The burden of COPD mortality due to ambient air pollution in Guangzhou, China
Authors: Li Li , Yang Jun , Song Yun-Feng , Chen Ping-Yan , Ou Chun-Quan 
Published: May 2016

AbstractFew studies have investigated the chronic obstructive pulmonary disease (COPD) mortality fraction attributable to air pollution and modification by individual characteristics of air pollution effects. We applied distributed lag non-linear models to assess the associations between air pollution and COPD mortality in 2007–2011 in Guangzhou, China and the total COPD mortality fraction attributable to air pollution was calculated as well. We found that an increase of 10 μg/m3 in particulate matter with an aerodynamic diameter of 10 μm or less (PM10), sulfur dioxide (SO2) and nitrogen dioxide (NO2) was associated with a 1.58% (95% confidence interval (CI): 0.12–3.06%), 3.45% (95% CI: 1.30–5.66%) and 2.35% (95% CI: 0.42–4.32%) increase of COPD mortality over a lag of 0–15 days, respectively. Greater air pollution effects were observed in the elderly, males and residents with low educational attainment. The results showed 10.91% (95% CI: 1.02–9.58%), 12.71% (95% CI: 5.03–19.85%) and 13.38% (95% CI: 2.67–22.84%) COPD mortality was attributable to current PM10, SO2 and NO2 exposure, respectively. In conclusion, the associations between air pollution and COPD mortality differed by individual characteristics. There were remarkable COPD mortality burdens attributable to air pollution in Guangzhou.
Evolving Trends in Female to Male Incidence and Male Mortality of Primary Biliary Cholangitis
Authors: Lleo Ana , Jepsen Peter , Morenghi Emanuela , Carbone Marco , Moroni Luca , Battezzati Pier Maria , Podda Mauro , Mackay Ian R. , Gershwin M. Eric , Invernizzi Pietro 
Published: May 2016

AbstractPrimary biliary cholangitis (PBC) has been regarded as female-predominant without evidence of gender difference in survival. We aimed to compare the overall survival, incidence and prevalence of PBC in two well defined population-based studies over a recent decade, considering also sex ratios and mortality. We have taken advantage of population-wide records, during 2000–2009, in Lombardia, Northern Italy and Denmark. We focused on the incident cases of PBC, including gender and outcome, among 9.7 million inhabitants of Lombardia and 5.5 million of Denmark. In Lombardia there were 2,970 PBC cases with a female:male ratio of 2.3:1. The age/sex-adjusted annual incidence of PBC was 16.7 per million. Point prevalence was 160 per million on January 1st 2009. In Denmark there were 722 cases of incident PBC, female:male ratio was 4.2:1 and the annual incidence was 11.4 per million, a point prevalence of 115 per million in 2009. Cox regression multivariate analysis identified male sex as an independent predictor of all-cause mortality in both Italian (HR 2.36) and Danish population (HR 3.04). Our data indicate for PBC a sex ratio significantly lower than previously cited, a reversal of the usual latitudinal difference in prevalence and a surprisingly higher overall mortality for male patients.
Endocytosis of indium-tin-oxide nanoparticles by macrophages provokes pyroptosis requiring NLRP3-ASC-Caspase1 axis that can be prevented by mesenchymal stem cells
Authors: Naji Abderrahim , Muzembo Basilua André , Yagyu Ken-ichi , Baba Nobuyasu , Deschaseaux Frédéric , Sensebé Luc , Suganuma Narufumi 
Published: May 2016

AbstractThe biological effects of indium-tin-oxide (ITO) are of considerable importance because workers exposed to indium compounds have been diagnosed with interstitial lung disease or pulmonary alveolar proteinosis; however, the pathophysiology of these diseases is undefined. Here, mice intraperitoneally inoculated with ITO-nanoparticles (ITO-NPs) resulted in peritonitis dependent in NLRP3 inflammasome, with neutrophils recruitment and interleukin-1β (IL-1β) production. Withal peritoneal macrophages exposed ex vivo to ITO-NPs caused IL-1β secretion and cytolysis. Further, alveolar macrophages exposed to ITO-NPs in vitro showed ITO-NP endocytosis and production of tumor necrosis factor-α (TNF-α) and IL-1β, ensued cell death by cytolysis. This cell death was RIPK1-independent but caspase1-dependent, and thus identified as pyroptosis. Endocytosis of ITO-NPs by activated THP-1 cells induced pyroptosis with IL-1β/TNF-α production and cytolysis, but not in activated THP-1 cells with knockdown of NLRP3, ASC, or caspase1. However, exposing activated THP-1 cells with NLRP3 or ASC knockdown to ITO-NPs resulted in cell death but without cytolysis, with deficiency in IL-1β/TNF-α, and revealing features of apoptosis. While, mesenchymal stem cells (MSCs) co-cultured with macrophages impaired both inflammation and cell death induced by ITO-NPs. Together, our findings provide crucial insights to the pathophysiology of respiratory diseases caused by ITO particles, and identify MSCs as a potent therapeutic.
Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism
Authors: Chen Yanyan , Wu Xiafang , Wu Ruirui , Sun Xiance , Yang Boyi , Wang Yi , Xu Yuanyuan 
Published: May 2016

AbstractChanges in profile of lipids and adipokines have been reported in patients with thyroid dysfunction. But the evidence is controversial. The present study aimed to explore the relationships between thyroid function and the profile of lipids and adipokines. A cross-sectional study was conducted in 197 newly diagnosed hypothyroid patients, 230 newly diagnosed hyperthyroid patients and 355 control subjects. Hypothyroid patients presented with significantly higher serum levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDLC), fasting insulin, resistin and leptin than control (p < 0.05). Hyperthyroid patients presented with significantly lower serum levels of high-density lipoprotein cholesterol, LDLC and leptin, as well as higher levels of fasting insulin, resistin, adiponectin and homeostasis model insulin resistance index (HOMA-IR) than control (p < 0.05). Nonlinear regression and multivariable linear regression models all showed significant associations of resistin or adiponectin with free thyroxine and association of leptin with thyroid-stimulating hormone (p < 0.001). Furthermore, significant correlation between resistin and HOMA-IR was observed in the patients (p < 0.001). Thus, thyroid dysfunction affects the profile of lipids and adipokines. Resistin may serve as a link between thyroid dysfunction and insulin resistance.