bluuebunny/crossref_metadata_2025_split huggingface dataset:
Politics and Justice at the International Criminal Court
Authors: Steinberg Richard H 
Published: September 2024

AbstractThe International Criminal Court (ICC) is a legal institution embedded in international politics. Politics shaped the Rome Statute of the ICC, which is rooted in norms and rules of European lineage and security interests of party states. Politics constrains and influences the operation of the Court, which has adapted in response to oversight and governance of the Assembly of States Parties, and to political actions extrinsic to institutional rules. The ICC also has political effects in situation states. A brief history shows that application of Rome Statute triggers across state parties with different social conditions skewed geographic distribution of its investigations and prosecutions towards Africa, a structural bias that catalysed a legitimation crisis for the ICC. Subsequent exercises of expansive jurisdiction aimed at nationals of non-African, non-party states – including Israel and some of the world's great powers – have dampened African complaints and advanced the ICC agenda, but intensified non-legitimacy claims by powerful non-party states. To survive, Court organs must follow legal mandates, yet be responsive to pressing international political demands, continuously risking the legitimacy of the ICC as a legal institution and adverse political reactions by antagonised governments. Careful management of the tension between law and politics at the ICC may modestly reduce antagonism towards the Court, but that tension cannot be resolved, and confrontations over the ICC's legitimacy are certain to recur.
A Chapter Homily
Authors: Alleluia Amen. 
Published: September 2024

For the Alleluia versicle of the Mass of the Aurora for Christmas Day, the Church has chosen the opening words of Psalm 92: ‘The Lord hath reigned, he is clothed with beauty: the Lord is clothed with strength and hath girded himself with power'. It is with the beauty of our humanity that the Lord has clothed himself today: he has put on the weakness of a child; but he has reigned, the Lord has reigned from the crib, just as he was to reign from the cross, and now reigns in heaven. Like Moses in the ark, today the Lord is found in a crib; and as the Son is counted of greater worth than the servant, so he will lead the new Israel into the Promised Land; for ‘from Egypt I have called my Son'.It was in an ark that Moses was found; and in an ark that Noe sailed over the waters of the great flood, both, Moses and Noe, bearing with them the seeds of new life.
Rosary Sunday
Authors: McNabb Vincent 
Published: September 2024

The Holy Gospel according to St Matthew, chapter ‘...And the
Pharisees being gathered together, Jesus asked them, saying, “What think
ye of Christ: whose son is he?” They say to him,
David’s”.’

I Have to speak to you tonight about the holy Rosary. There are, of
course, ten thousand things to be said about it, the least of which is a
glorious battle on which probably depended the civilisation of the world;
but I am going to allow a little child to lead me and you into the
Rosary.
There are not many trees in London streets, but there are a great number
of children—better than trees of course—and God, in his goodness, often
allows little children to hail me. The other day I was passing through one
of our streets, close at hand, made beautiful with the feet of little
children and their gambols, and two little ones I found suddenly by my side.
I think they must have crossed the little narrow street; I don’t know. I
only know that suddenly I found two little ones by my side. I think their
aggregate age would be about six.
The Church's Earliest Hymns
Authors: Potter Roland 
Published: September 2024

The Hebrew Psalter became and has been for centuries I the great hymn-book of the Church. The wonder of this A book of ‘Praises’ has, very rightly, been made manifest through its long history. Very closely akin are the Canticles in St Luke's Gospel. These represent a genre of their own: we might say New Testament ideas in Old Testament dress. Thus the Magnificat of our Lady is modelled on the Canticle of Anna (I Sam. 2, I-IO) and recalls the Song of Miriam (Exod. 15, 1-21), the Benedictus echoes the language of psalms and prophecies, and the Nunc Dimittis is redolent of passages in Isaiah.Alongside the more hebraic traditions of prayer and praise we can discern the beginnings of more specifically Christian, and indeed Christological, hymns.
Hepatic and splenic venous access tract closure using the VASCADE vascular closure system following percutaneous intervention in patients with CHD
Authors: Eilers Lindsay F. , Bansal Manish , Khan Asra , Webb Melissa K. , Qureshi Athar M. , Gowda Srinath T. , Stapleton Gary E. 
Published: September 2024

AbstractBackground:Hepatic and splenic venous access are specialised techniques used to perform diagnostic and interventional procedures in the cardiac catheterisation laboratory. Bleeding events are the most commonly reported complication following hepatic or splenic venous access. The VASCADE Vascular Closure System (Cardiva Medical Inc. Santa Barbara, CA) is an approved device for closure of femoral vascular access tracts in patients ≥18 years of age. We report our experience using VASCADE to close the hepatic or splenic venous access site in the cardiac catheterisation laboratory.Methods:This is a single centre retrospective review of all patients who had percutaneous hepatic or splenic venous access obtained in the cardiac catheterisation laboratory from March 1, 2022 through October 30, 2023 and underwent tract closure with VASCADE.Results:Ten patients (six male) underwent 16 procedures (median age and weight 3.5 years and 12.5 kg) with 15 hepatic and two splenic veins accessed. Successful closure of the access tracts with VASCADE was performed in all patients. There were no major adverse events related to closure of the access sites with VASCADE.Conclusion:VASCADE can be used following transhepatic and trans-splenic venous access in the cardiac catheterisation laboratory to safely close the access tract and potentially reduce the risk of post-procedural bleeding complications. Further evaluation in a larger cohort of patients is needed to ensure VASCADE is safe for use and provides adequate haemostasis following hepatic or splenic venous access, particularly in children.
Plasma Structure Decay Rates in the Equatorial Ionosphere Are Strongly Coupled by Turbulence
Authors: Ivarsen M. F. , St‐Maurice J.‐P. , Park J. , Klenzing J. , Jin Y. , Lee W. 
Published: September 2024

AbstractEquatorial plasma irregularities in the ionospheric F‐region proliferate after sunset, causing the most apparent radio scintillation “hot‐spot” in geospace. These irregularities are caused by plasma instabilities, and appear mostly in the form of under‐densities that rise up from the F‐region's bottomside. After an irregularity production peak at sunset, the amplitude of the resulting turbulence decays with time. Analyzing a large database of irregularity spectra observed by one of the European Space Agency's Swarm satellites, we have applied a novel but conceptually simple statistical analysis to the data, finding that turbulence in the F‐region tends to decay with a uniform, scale‐independent rate, thereby confirming and extending the results from an earlier case study. We find evidence for two regimes, one valid post‐sunset (1.4 hr decay rate) and one valid post‐midnight (2.6 hr). Our results should be of utility for large‐scale space weather modeling efforts that are unable to resolve turbulent effects.
Orbital Tuning of Short Reversed Geomagnetic Polarity Intervals in the Cretaceous Normal Polarity Superchron
Authors: Ramos J. M. F. , Savian J. F. , Franco D. R. , Figueiredo M. F. , Leandro C. G. , Frontalini F. 
Published: September 2024

AbstractWhile the Cretaceous Normal Polarity Superchron has documented instances of brief reversed polarity intervals, the absence of accurate age determinations for such abrupt shifts poses a challenge in leveraging them as reliable reference tiepoints. This study presents a cyclostratigraphic analysis of gamma‐ray data from the DSDP Site 402A. The identification of Milankovitch cycles allowed us to construct a 405‐kyr astronomically‐tuned age model for two reversed events that occurred in the Aptian. Our results estimate an age of 117.03 ± 0.14 Ma for the Chron M”‐1r” or ISEA and 116.17 ± 0.14 Ma for reversal “2,” with timespans of ∼20 and ∼10 kyr, respectively. Sedimentation patterns are influenced by orbital eccentricity cycles with an average sedimentation rate of 5 cm/kyr. The short time intervals related to these reversals exposes the difficulty in their detection in cores through paleomagnetic analysis as well as in deep‐tow surveys.
Quasi‐Periodic EMIC Waves and Pulsating Ionospheric Perturbations Related to ULF Waves
Authors: Ma Longxing , Yu Yiqun , Tong Xin , Tang Linhui , Liu Wenlong , Cao Jinbin , Wu Jun , Wu Jian 
Published: September 2024

AbstractPulsating proton auroras are often attributed to periodic proton precipitation. However, how the proton precipitation is periodically generated in the magnetosphere remains an open issue. Utilizing multi‐point space‐borne and ground‐based observations, this study proposed a potential mechanism responsible for pulsating proton precipitation and intermittent ionospheric electron density disturbances. On 8 September 2017, Pc4 ULF waves and electromagnetic ion cyclotron (EMIC) wave packets were simultaneously observed by Van Allen Probes (RBSP) in the inner magnetosphere. The EMIC wave packets were quasi‐periodically excited at the same frequency as the ULF waves, which resulted in 30–100 keV proton precipitation detected by Low‐Earth‐Orbit (LEO) POES satellites. Meanwhile, conjugate European Incoherent Scatter (EISCAT) radar on the ground observed E‐region electron density enhancements that intermittently appeared nearly at the same frequency as the EMIC wave packets in space. These observations together suggest that ULF waves in the magnetosphere are the ultimate driver that modulates quasi‐periodic EMIC waves to induce proton precipitation and pulsating disturbances in the ionosphere.
Peat Particulate Organic Matter Accepts Electrons During In Situ Incubation in the Anoxic Subsurface of Ombrotrophic Bogs
Authors: Obradović Nikola , Schmitz Rob A. , Haffter Frédéric , Meier Dimitri V. , Lever Mark A. , Schroth Martin H. , Sander Michael 
Published: September 2024

AbstractPeat particulate organic matter (POM) in the anoxic subsurface of peatlands is increasingly recognized as an important terminal electron acceptor (TEA) in anaerobic respiration. While POM reduction has been demonstrated in laboratory peat‐soil incubations and (electro‐) chemical reduction assays, direct demonstration of POM reduction in peat soils under in situ, field conditions involving quantification of transferred electrons remain missing. Herein, we demonstrate that deployment of an oxidized reference POM in the anoxic, methanogenic subsurface of three ombrotrophic bogs, followed by one year incubation, resulted in the transfer of approximately 150–170 μmol of electrons per gram POM to the deployed reference POM. The capacity of this reduced POM to accept electrons was partially restored upon subsequent exposure to dissolved oxygen. These findings provide direct evidence for POM acting as regenerable and sustainable TEA for anaerobic respiration in temporarily anoxic parts of peat soils. Based on the number of electrons transferred to POM and thermodynamic considerations, we estimate that anaerobic respiration to POM may largely suppress methanogenesis in peat soils, particularly close to the oxic‐anoxic interface across which POM is expected to undergo redox cycling.
Orthodontic bonding in special circumstances
Authors: Burns Angus , Hughes Annie , O’Sullivan Michael 
Published: September 2024

AbstractThis clinical paper provides an in-depth exploration of advanced techniques for bonding orthodontic attachments under special circumstances. Challenges arise when bonding brackets to non-enamel surfaces, such as dental restorations, and in conditions such as amelogenesis imperfecta, which affect enamel integrity. Distinct approaches required for bonding to different restorative materials, including glassy ceramics, zirconia, resin composites and metals, are outlined. Moreover, we describe strategies to manage bonding in conditions including amelogenesis imperfecta, hypodontia and microdontia in a multidisciplinary context.
Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners
Authors: Hollingsworth Kristian , Di Maio Antonio , Richards Sarah-Jane , Vendeville Jean-Baptiste , Wheatley David E. , Council Claire E. , Keenan Tessa , Ledru Hélène , Chidwick Harriet , Huang Kun , Parmeggiani Fabio , Marchesi Andrea , Chai Wengang , McBerney Ryan , Kamiński Tomasz P. , Balmforth Matthew R. , Tamasanu Alexandra , Finnigan James D. , Young Carl , Warriner Stuart L. , Webb Michael E. , Fascione Martin A. , Flitsch Sabine , Galan M. Carmen , Feizi Ten , Gibson Matthew I. , Liu Yan , Turnbull W. Bruce , Linclau Bruno 
Published: September 2024

AbstractGlycan-mediated interactions play a crucial role in biology and medicine, influencing signalling, immune responses, and disease pathogenesis. However, the use of glycans in biosensing and diagnostics is limited by cross-reactivity, as certain glycan motifs can be recognised by multiple biologically distinct protein receptors. To address this specificity challenge, we report the enzymatic synthesis of a 150-member library of site-specifically fluorinated Lewisx analogues (‘glycofluoroforms’) using naturally occurring enzymes and fluorinated monosaccharides. Subsequent incorporation of a subset of these glycans into nanoparticles or a microarray revealed a striking spectrum of distinct binding intensities across different proteins that recognise Lewisx. Notably, we show that for two proteins with unique binding sites for Lewisx, glycofluoroforms exhibited enhanced binding to one protein, whilst reduced binding to the other, with selectivity governed by fluorination patterns. We finally showcase the potential diagnostic utility of this approach in glycofluoroform-mediated bacterial toxin detection by lateral flow.
Somatic mutations in 3929 HPV positive cervical cells associated with infection outcome and HPV type
Authors: Pinheiro Maisa , Wentzensen Nicolas , Dean Michael , Yeager Meredith , Chen Zigui , Shastry Amulya , Boland Joseph F. , Bass Sara , Burdett Laurie , Lorey Thomas , Mishra Sambit , Castle Philip E. , Schiffman Mark , Burk Robert D. , Zhu Bin , Mirabello Lisa 
Published: September 2024

AbstractInvasive cervical cancers (ICC), caused by HPV infections, have a heterogeneous molecular landscape. We investigate the detection, timing, and HPV type specificity of somatic mutations in 3929 HPV-positive exfoliated cervical cell samples from individuals undergoing cervical screening in the U.S. using deep targeted sequencing in ICC cases, precancers, and HPV-positive controls. We discover a subset of hotspot mutations rare in controls (2.6%) but significantly more prevalent in precancers, particularly glandular precancer lesions (10.2%), and cancers (25.7%), supporting their involvement in ICC carcinogenesis. Hotspot mutations differ by HPV type, and HPV18/45-positive ICC are more likely to have multiple hotspot mutations compared to HPV16-positive ICC. The proportion of cells containing hotspot mutations is higher (i.e., higher variant allele fraction) in ICC and mutations are detectable up to 6 years prior to cancer diagnosis. Our findings demonstrate the feasibility of using exfoliated cervical cells for detection of somatic mutations as potential diagnostic biomarkers.
Podocyte-specific KLF6 primes proximal tubule CaMK1D signaling to attenuate diabetic kidney disease
Authors: Gujarati Nehaben A. , Frimpong Bismark O. , Zaidi Malaika , Bronstein Robert , Revelo Monica P. , Haley John D. , Kravets Igor , Guo Yiqing , Mallipattu Sandeep K. 
Published: September 2024

AbstractDiabetic kidney disease (DKD) is the main cause of chronic kidney disease worldwide. While injury to the podocytes, visceral epithelial cells that comprise the glomerular filtration barrier, drives albuminuria, proximal tubule (PT) dysfunction is the critical mediator of DKD progression. Here, we report that the podocyte-specific induction of human KLF6, a zinc-finger binding transcription factor, attenuates podocyte loss, PT dysfunction, and eventual interstitial fibrosis in a male murine model of DKD. Utilizing combination of snRNA-seq, snATAC-seq, and tandem mass spectrometry, we demonstrate that podocyte-specific KLF6 triggers the release of secretory ApoJ to activate calcium/calmodulin dependent protein kinase 1D (CaMK1D) signaling in neighboring PT cells. CaMK1D is enriched in the first segment of the PT, proximal to the podocytes, and is critical to attenuating mitochondrial fission and restoring mitochondrial function under diabetic conditions. Targeting podocyte-PT signaling by enhancing ApoJ-CaMK1D might be a key therapeutic strategy in attenuating the progression of DKD.
A unified moment tensor potential for silicon, oxygen, and silica
Authors: Zongo Karim , Sun Hao , Ouellet-Plamondon Claudiane , Béland Laurent Karim 
Published: September 2024

AbstractSi and its oxides have been extensively explored in theoretical research due to their technological importance. Simultaneously describing interatomic interactions within both Si and SiO2 without the use of ab initio methods is considered challenging, given the charge transfers involved. Herein, this challenge is overcome by developing a unified machine learning interatomic potentials describing the Si/SiO2/O system, based on the moment tensor potential (MTP) framework. This MTP is trained using a comprehensive database generated using density functional theory simulations, encompassing diverse crystal structures, point defects, extended defects, and disordered structure. Extensive testing of the MTP is performed, indicating it can describe static and dynamic features of very diverse Si, O, and SiO2 atomic structures with a degree of fidelity approaching that of DFT.
Unobtrusive measurement of cognitive load and physiological signals in uncontrolled environments
Authors: Anders Christoph , Moontaha Sidratul , Real Samik , Arnrich Bert 
Published: September 2024

AbstractWhile individuals fail to assess their mental health subjectively in their day-to-day activities, the recent development of consumer-grade wearable devices has enormous potential to monitor daily workload objectively by acquiring physiological signals. Therefore, this work collected consumer-grade physiological signals from twenty-four participants, following a four-hour cognitive load elicitation paradigm with self-chosen tasks in uncontrolled environments and a four-hour mental workload elicitation paradigm in a controlled environment. The recorded dataset of approximately 315 hours consists of electroencephalography, acceleration, electrodermal activity, and photoplethysmogram data balanced across low and high load levels. Participants performed office-like tasks in the controlled environment (mental arithmetic, Stroop, N-Back, and Sudoku) with two defined difficulty levels and in the uncontrolled environments (mainly researching, programming, and writing emails). Each task label was provided by participants using two 5-point Likert scales of mental workload and stress and the pairwise NASA-TLX questionnaire. This data is suitable for developing real-time mental health assessment methods, conducting research on signal processing techniques for challenging environments, and developing personal cognitive load assistants.
Effectiveness of non-pharmaceutical interventions for COVID-19 in USA
Authors: Liu Yuhang , Wang Weihao , Wong Weng-Kee , Zhu Wei 
Published: September 2024

AbstractWorldwide, governments imposed non-pharmaceutical interventions (NPIs) during the COVID-19 pandemic to contain the pandemic more effectively. We examined the effectiveness of individual NPIs in the United States during the first wave of the pandemic. Three types of analyses were performed. First, a prototypical Bayesian hierarchical model was employed to gauge the effectiveness of five NPIs and they are gathering restriction, restaurant capacity restriction, business closure, school closure, and stay-at-home order in the 42 states with over 100 deaths by the end of the wave. Second, we examined the effectiveness of the face mask mandate, the sixth and most controversial NPI by counterfactual modeling, which is a variant of the prototypical Bayesian hierarchical model allowing us to answer the question of what if the state had imposed the mandate or not. The third analysis used an advanced Bayesian hierarchical model to evaluate the effectiveness of all six NPIs in all 50 states and the District of Columbia, and thereby provide a full-scale estimation of the effectiveness of NPIs and the relative effectiveness of each NPI in the entire United States. Our results have enhanced the collective knowledge on the general effectiveness of NPIs in arresting the spread of COVID-19.
MultiMatch: geometry-informed colocalization in multi-color super-resolution microscopy
Authors: Naas Julia , Nies Giacomo , Li Housen , Stoldt Stefan , Schmitzer Bernhard , Jakobs Stefan , Munk Axel 
Published: September 2024

AbstractWith recent advances in multi-color super-resolution light microscopy, it is possible to simultaneously visualize multiple subunits within biological structures at nanometer resolution. To optimally evaluate and interpret spatial proximity of stainings on such an image, colocalization analysis tools have to be able to integrate prior knowledge on the local geometry of the recorded biological complex. We presentMultiMatchto analyze the abundance and location of chain-like particle arrangements in multi-color microscopy based on multi-marginal optimal unbalanced transport methodology. Our object-based colocalization model statistically addresses the effect of incomplete labeling efficiencies enabling inference on existent, but not fully observable particle chains. We showcase that MultiMatch is able to consistently recover existing chain structures in three-color STED images of DNA origami nanorulers and outperforms geometry-uninformed triplet colocalization methods in this task. MultiMatch generalizes to an arbitrary number of color channels and is provided as a user-friendly Python package comprising colocalization visualizations.