bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of ecological flow based on probability distributions of annual and monthly flows
Authors: Feng Baofei , Zhang Xiao , Yan Fangjia , Zhang Yu 
Published: October 2024

ABSTRACT
Developing scientifically sound ecological flow is crucial for protecting river ecosystems. However, most of the existing hydrological methods for determining ecological flow make it difficult to consider both inter-annual and intra-annual changes in runoff. To compensate for this shortcoming, this paper proposes an innovative ecological flow determination method based on the probability distributions of annual and monthly flows. Marginal distributions of annual and monthly flows are first fitted, and the Copula function is used to create joint probability distributions of annual and monthly flows. Conditional probabilities for different monthly flow sizes under different annual flow conditions are then calculated based on Bayesian inference. The conditional probabilities are combined with the flow–duration curve-–based method to finalize the ecological flow process considering both intra- and inter-annual runoff changes. A case study was conducted in Jinsha River, China. The results show that the total annual ecological water demand of the Jinsha River is 1.50, 1.25, and 1.04 × 1011 m3 under annual flow scenarios of high, medium, and low flows, respectively, which provide a red line for the development of water resources and hydro-energy resources of the Jinsha River, as well as for the better protection of the natural plant and animal species.
Groundwater pollution by nitrate and salinization in Morocco: a comprehensive review
Authors: Sanad Hatim , Oueld lhaj Majda , Zouahri Abdelmjid , Saafadi Laila , Dakak Houria , Mouhir Latifa 
Published: October 2024

ABSTRACT
Groundwater plays a critical role in supporting a wide range of human activities. However, it faces substantial challenges due to the growing demand for water and reduced precipitation resulting from climate change. Various studies have revealed the high vulnerability of Morocco's groundwater to contamination from multiple anthropogenic sources. This review focuses on assessing nitrate and salinization pollution in Moroccan groundwater, with a specific emphasis on the Gharb region. A comprehensive analysis of research conducted from 2010 to 2023, using reputable databases, underscores the pressing need to address groundwater pollution in Morocco, especially in the Gharb region. The results highlight the significant challenges faced by Morocco's groundwater resources. Agricultural practices and poorly designed irrigation systems are identified as primary contributors to nitrate contamination. Additionally, salinization in the region is influenced by factors such as seawater intrusion, hydrogeological characteristics, and irrigation practices. An integrated approach, combining laboratory analysis, remote sensing, geospatial tools, modeling, and geographic information systems technology, has proven to be effective in addressing the complex issues of assessing groundwater pollution due to nitrate and salinization. This survey presents a comprehensive framework for future research and decision-making processes aimed at achieving sustainable water resource management, preserving the groundwater heritage and safeguarding public health.
The influence of the industrial organization on farmers' willingness to adopt water-saving irrigation technologies: a perspective of organizational support
Authors: Deng Yashan , Lu Qian , Cha Jianping 
Published: October 2024

ABSTRACT

Water scarcity and inefficiency hinder China's sustainable agriculture. Water-saving irrigation (WSI) technology, as a crucial means to improve water efficiency, has relatively low adoption rates. In this context, this study utilizes survey data from 1,178 farmers in the Yellow River Basin in China, employing both the Binary Probit model and the Iv-Probit model to deeply explore the influence and mechanism of industrial organizations on farmers' willingness to adopt WSI technology. Our study shows that organizational participation behavior and degree of organizational support can effectively enhance farmers' willingness to adopt WSI technology. Organizational support indirectly enhances farmers' willingness to adopt WSI technology by standardizing production, providing agricultural training, and being proactive in learning agricultural techniques. Furthermore, organizational support has a significant impact on farmers with low education, young age, large land management areas, and poor agricultural production conditions. Our study also found that organizational support and government support can play a synergistic role in promoting farmers' willingness to adopt WSI technology. Therefore, it is necessary to strengthen the cultivation of industrial organizations, improve the governance structure of industrial organizations, strengthen the institutional guarantee of industrial organizations, and pay attention to the heterogeneity of farmer groups when leveraging the role of industrial organizations.
Structural Insights and Biological Activities of Furan-Based Drugs in the Treatment of Human Diseases
Authors: Mishra Avinash Kumar , Singh Kuldeep , Saha Sunam , Bhardwaj Harsh , Gupta Jeetendra Kumar , Shah Kamal , Kumar Shivendra , Jain Divya , Verma Hritik 
Published: October 2024

Abstract:
Neurodegenerative diseases present significant public health challenges, driving the
search for innovative therapeutic strategies. This review explores the neuroprotective potential of
furan-containing compounds, which are derived from various natural and synthetic sources. These
compounds are observed for their diverse pharmacological activities, including antioxidant
and anti-inflammatory properties. By scavenging free radicals and mitigating oxidative stress,
they address a key aspect of neurodegeneration. Additionally, furan derivatives modulate inflammatory
pathways, potentially reducing neuroinflammation, a critical factor in the progression
of these disorders. The review also highlights the impact of these compounds on neuronal
survival and regeneration, suggesting their role in promoting neurogenesis and enhancing neuronal
plasticity. Their interactions with neurotransmitter systems further support their neuroprotective
effects, particularly in maintaining synaptic function and neurotransmission. The potential
applications of furan-containing compounds are discussed concerning specific neurodegenerative
diseases, such as Alzheimer's and Parkinson's. Insights from preclinical studies and in
vitro experiments underscore their therapeutic promise across various experimental models.
While still in the early stages of research, the evidence suggests that furan-containing compounds
could be valuable in developing effective interventions for neurodegenerative diseases.
This review emphasizes the need for further investigation into these compounds to realize their
potential as neuroprotective agents fully.
Biomarkers and Novel Therapies of Diabetic Neuropathy: An Updated Review
Authors: Aziz Namra , Nehere Shital Vijay , Sinha Rishika , Satyarthy Rajeev , Prajapati Harshit , Panigrahy Uttam Prasad , Sharma Mukesh Chandra , Kumar Pankaj , Wal Pranay 
Published: October 2024

Abstract:
Diabetic neuropathy is a persistent consequence of the biochemical condition known
as diabetes mellitus. As of now, the identification and management of diabetic neuropathy continue
to be problematic due to problems related to the safety and efficacy of existing therapies.
This study examines biomarkers, molecular and cellular events associated with the advancement
of diabetic neuropathy, as well as the existing pharmacological and non-pharmacological treatments
employed. Furthermore, a holistic and mechanism-centric drug repurposing approach,
antioxidant therapy, Gene and Cell therapies, Capsaicin and other spinal cord stimulators and
lifestyle interventions are pursued for the identification, treatment and management of diabetic
neuropathy. An extensive literature survey was done on databases like PubMed, Elsevier, Science
Direct and Springer using the keywords “Diabetic Neuropathy”, “Biomarkers”, “Cellular
and Molecular Mechanisms”, and “Novel Therapeutic Targets”.Thus, we may conclude that
non-pharmacological therapies along with palliative treatment, may prove to be crucial in halting
the onset of neuropathic symptoms and in lessening those symptoms once they have occurred.
Bridging the Gap: Quality by Design as a Catalyst for Enhanced Quality Management Systems in Biopharmaceutical Manufacturing
Authors: Saxena Shivang , Saxena Shubhi , Diksha  , Patil Niraj S. , Ranjan Animesh , Singh Amandeep 
Published: October 2024

Abstract:
The document emphasizes the importance of addressing key issues in Quality Management
Systems (QMS) to stay competitive and provide high-quality goods and services in a dynamic
market. It highlights the need to adopt novel quality management techniques for long-term success.
The fundamentals of Quality by Design (QbD) are discussed, tracing back to pioneers like
Joseph M. Juran and the Six Sigma concept for effective implementation. QbD is described as a
systematic approach focusing on risk management, Quality Target Product Profile (QTPP), and
Critical Quality Attributes (CQAs) to create products meeting predetermined quality standards.
QbD incorporates quality concepts into the development and production processes. Its goal is to
guarantee the quality of the product by determining and managing important factors. Manufacturers
can be flexible with it while still adhering to strict quality standards. It signifies a change in the
industry's paradigm.
A Brief Review-an Update on 1,3,4-Oxadiazole
Authors: M Yokkesh , AS Vishal Pranav , Chandurwala Sarah , J Vinethmartin , Arun Sowmiya , B Gowramma , L Kaviarasan 
Published: October 2024

Abstract:
The 1,3,4-oxadiazole nucleus is a biologically necessary scaffold that exhibits a wide
range of pharmacological activities. The broad and strong activity of 1,3,4-oxadiazole and their
derivatives has established them as significant pharmacological scaffolds, particularly in the
treatment of cancer disease. A number of di-, tri-, aromatic, and heterocyclic substituted 1,3,4-
oxadiazole derivatives have been reported to possess potent biological activities; these substituted
1,3,4-oxadiazoles had different mechanisms of action and contributed to the development of biologically
active drugs. This review is intended to supplement previous reviews by reviewing the
literature on the different activities of 1,3,4-oxadiazole derivatives from the last fifteen years.
1,3,4-oxadiazole can be produced in a number of ways and has a wide range of possible pharmacological
uses. As a result, scientists have created novel procedures for the production of 1,3,4-
oxadiazole derivatives and their use in medicine presently. Anticancer, antibacterial, antiinflammatory,
anti-HIV, anti-tubercular, anti-diabetic, antifungal, and other properties are among
the activities. In this review, we discussed various research works based on 1,3,4-oxadiazole derivatives
synthetic procedure and assessment of different biological activities. Many researchers
may find the material on this page helpful, which could lead to the discovery of new medicinal
species for society.
Chemistry and Biotechnological Insights of Rhynchostylis retusa (L.) Blume: A Mini-Review
Authors: Kumari Anjna , Kaundal Rishabh , Roy Tina , Walia Yogesh Kumar , Kumar Dinesh 
Published: October 2024

Abstract:
Rhynchostylis retusa (L.) Blume belongs to the Vanda alliance of the Orchidaceae family
and is mostly distributed from 300-1,500 m. It is traditionally practiced for the treatment of
health issues such as dysentery, pain, inflammation, arthritis, and, skin, respiratory, heart, kidney,
brain, and menstrual problems. R. retusa is also used in folklore claims to recover from tuberculosis,
vertigo, anemia, and bone fractures. Further, some of the traditional claims were scientifically
validated through preclinical (In vitro & in vivo) studies. With the view of tremendous
health benefits, the current study was focused on harnessing the information through search engines
(Google Scholar, Scopus-Elsevier, Medline, Sci Finder, Web of Science, Plant list, and Directory
of Open Access Journal) till October 2022 and compile them as a comprehensive review.
Therefore, detailed, comprehensive information on botanical distribution, ethnopharmacological
and ornamental values, chemistry, biotechnological interventions for smart cultivation, pharmacological
activities, conservation status, patents, and future perspectives of the R. retusa has been
compiled. The comprehensive review of the Foxtail Orchid (R. retusa) has unremarkable potential
and still needs to be explored from chemical, pharmacological, quality control, and value addition
perspectives. The review will help the orchid community as well as researchers and farmers
working on orchids.
Concerns and Safety Evaluation Indicators for Compatibility Study of Injections with Prefilled Syringe
Authors: Chen Chao , Jin Yuqi , Cai Zhiwei , Fu Shasha , Zhu Peixi , Ruhlmann Laurent 
Published: October 2024

Abstract:
Prefilled syringe is a multi-component injector drug packaging system in which liquid
drugs are directly loaded for direct use by patients. It has two functions, drug storage and regular
injection, which belongs to high-risk pharmaceutical packaging containers. In recent years, more and
more injections have been packaged with prefilled syringes worldwide. However, no guidelines
about compatibility of chemical injections and prefilled syringes was set up. In current review, studies
related to the compatibility study was summarized. Structural composition, material composition
and production technology are analyzed first. After that, extraction test, interaction study and safety
study are summarized. Glass components, plastic components, seal elastomer components, other
components and materials, adsorption test and physical properties are the main focusing points.
Based on the studies mentioned above, together with the results of extraction test, migration test and
adsorption test, safety evaluation indexes could be formed. The current review aims to provide strategies
for the setting up of compatibility study guidelines.
Elucidation of DNA binding properties of transition metal ion complexes of curcumin: An In Vitro study
Authors: MK Divya Darasan , T Janesh , Selvaraj Stalin 
Published: October 2024

Introduction:
The present work aims to synthesize, characterize, and DNA binding properties
of copper, nickel, zinc, and iron complexes of a well-known polyphenol drug curcumin. The
metal ion complexes of curcumin's synthesized transition metal ion complexes were characterized by
UV-vis spectroscopy and FTIR.

Method:
The complexation of curcumin with transition metal ion complexes changes the color of the
curcumin based on the metal incorporated. Moreover, the shift in the absorption maxima of curcumin
metal ion complexes may confirm the formation of coordination complexes. Then, FTIR results indicated
that the coordination of curcumin with metal ions in the ketone group of curcumin confirms the
formation of 1:2 (M: L) complexes.

Results:
Then, we evaluated the DNA binding properties of synthesized metal ion complexes of
curcumin using electronic absorption spectra and agarose gel electrophoresis. The results indicated
that the curcumin zinc complex exhibited less DNA binding constant among the four metal ion complexes
than all the other compounds tested, confirming its weak interaction.

Conclusion:
Moreover, all the compounds degrade plasmid DNA, confirming their DNA cleavage
activity. From our findings, these compounds will pave the way for developing new anticancer drugs
with less toxicity.
Enhancing Indoor Localization Accuracy in Wireless Sensor Networks: A Hybrid Approach Integrating Hierarchical Structure Poly Particle
Swarm Optimization and Teaching–Learning-Based Optimization (HSPPSO-TLBO)
Authors: Gumaida Bassam , Ibrahim Adamu Abubakar 
Published: October 2024

Background and Objective:
Enhancing localization accuracy while minimizing development
costs poses significant challenges in deploying and managing wireless sensor networks
(WSNs). This paper presents an advanced algorithm for node localization in indoor environments,
integrating sophisticated optimization techniques. The hybrid algorithm, HSPPSO-TLBO, combines
Hierarchical Structure Poly Particle Swarm Optimization (HSPPSO) with Teaching–
Learning-Based Optimization (TLBO).

Methods:
The proposed algorithm HSPPSO-TLBO aims to minimize the mean squared range error
(MSRE) resulted by calculating internal distances between nodes using Received Signal Strength
Indicator (RSSI). TLBO, with its robust global search capabilities, complements HSPPSO’s local
search, preventing convergence to inappropriate local optima. HSPPSO-TLBO offers easy implementation
and leverages the cost-free feature of RSSI, making it an attractive choice for enhancing
localization precision.

Results:
Simulation results demonstrate the superior performance of HSPPSO-TLBO compared to
other algorithms using different meta-heuristic optimization techniques. The outstanding performance
of HSPPSO-TLBO is evident across various evaluation metrics, including localization error,
localization rate, and simulation runtime.

Conclusion:
The proposed algorithm utilizing HSPPSO and TLBO is exceptionally effective in
improving localization precision in indoor WSNs due to several key characteristics. These include
the seamless integration and easy implementation of both HSPPSO and TLBO, along with the costfree
advantage of using the RSSI technique. This combination makes the algorithm a highly functional
solution for improving localization accuracy.

other:
N/A
Therapeutic and Diagnostic Implications of Carbon Dot: An Advancement in the Avenue towards Cancer, Diabetes and Neurodegenerative Disorders
Authors: Manna Sreejan , Banerjee Sabyasachi , De Arnab , Banerjee Subhasis , Das Stabak , Rakshit Pallabita , S K Ashok Kumar , Sen Kalyan Kumar , De Sourav 
Published: October 2024

Introduction:
Carbon dots (CDs), by virtue of their electrical and optical properties,
emit intense light and fluorescence. They have attributes like photostability, high quantum yield
(QY), high emission, and scalability. In the recent past, theranostic-CDs have been widely used in
sensing, imaging, and medication administration. Furthermore, CDs may provide significant
promise to detect and ability to cross blood-brain barrier (BBB) along with a drug to treat numerous
neurodegenerative disorders (ND), such as Parkinson's disease (PD), Alzheimer's disease
(AD), and multiple sclerosis.

Method:
This review aims at exploring the immense utility of CDs in the arena of theranostics.
The immense utility of CDs was investigated through a systematic exploration of previously published
data in the relevant field. The application of CDs is well extended to treat life-threatening disorders,
like diabetes and cancer. In order to keep harmful substances out of the brain, the blood-
-brain barrier (BBB) forms a defensive barrier.

Results:
Water and gases being simple molecules can traverse the BBB without getting filtered
out, but several large molecules suffer to reach the site of action owing to their poor solubility.
CDs have recently been employed for delivering drugs to the brain and to assess the central nervous
system. An in-depth study of relevant literature indicates that CDs are the next-generation
carrier with an innate potential to subside the drawbacks of conventional nanoparticles.

Conclusion:
This review illustrates several biomedical applications of CDs, primarily focusing on
neurological illnesses, diabetes, and cancers. It also confers the usefulness of CDs in diagnostic
imaging.
Understanding Morning Emotions by Analyzing Daily Wake-Up Alarm Usage: Longitudinal Observational Study
Authors: Oh Kyue Taek , Ko Jisu , ­Jin Nayoung , Han Sangbin , Yoon Chan Yul , Shin Jaemyung , Ko Minsam 
Published: October 2024

Background
Morning emotions can significantly affect daily wellness. While many studies have analyzed daily survey responses to identify factors influencing morning emotions, these methods require additional time and effort from individuals for emotional monitoring.

Objective
This study aims to identify daily alarm usage patterns related to morning emotions.

Methods
We recruited 373 users of the Alarmy app (DelightRoom) in the United States and South Korea and surveyed their demographics and usual behaviors related to morning emotions. Participants described their morning emotions over a 2-week period, during which we collected daily alarm app logs. We used a generalized estimating equation (GEE) method to identify factors affecting morning emotions.

Results
The findings indicate that varied alarm usage is related to morning emotions. Alarm set time was positively associated with feelings of peacefulness and refreshment in the morning, while task-based alarms were related to nervousness. The time taken to deactivate the alarm after it rang was negatively correlated with happiness. In addition, usual behaviors and demographic factors were found to be related to morning emotions, consistent with previous studies.

Conclusions
The study reveals that daily alarm usage is related to morning emotions, suggesting that daily alarm logs can supplement survey methods to facilitate daily emotion monitoring.
Relationship between knowledge and adherence to use of TB drugs in adults in Idaman Banjarbaru Hospital
Authors: WATI HELMINA , Kurniawan Guntur , Abdurrahman Faizah 
Published: October 2024

Background: Worldwide, tuberculosis (TB) is the disease that causes the highest mortality rate. One of the causes is the bacteria Mycobacterium Tuberculosis. Knowledge and adherence are very important in TB treatment to achieve therapeutic success. Objectives: This study aims to see the relationship between the level of knowledge and adherence to taking medication for adult TB patients at Idaman Banjarbaru Hospital. Methods: This type of research is descriptive research with a cross-sectional research design prospectively taken in March - June 2023. The number of patients was 42 people using the total sampling technique. Data were collected through an online questionnaire and then analyzed using the SPSS Fisher Exact test with a 95% confidence level. Results: The results showed that patients had a good level of knowledge of as many as 32 people (76.2%) and had less knowledge of as many as 10 people (23.8%). The value of patient compliance in taking medication was 29 people (69%), and disobedient as many as 13 people (31%). Conclusion: The results of the statistical analysis concluded that there was a relationship between knowledge and compliance with taking medication in TB patients at Idaman Banjarbaru Hospital (p < 0.05).