bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can multiphase dynamic CT angiography provide a better assessment of aortic dissection compared with the standard triphasic protocol?
Authors: Lu Chun-yan , Diao Yi-ke , Guo Ying-qiang , Zhang Xiao-hui , Bai Hong-li , Li Zhen-lin 
Published: April 2017

Background Acute aortic dissection (AD) is a life-threatening medical emergency. It has been debated whether the multiphase dynamic computed tomography angiography (CTA) protocol is superior to the standard triphasic protocol for revealing the characteristics of AD. Purpose To examine two multiphase dynamic protocols, Dynamic four-dimensional (4D) CTA using the shuttle mode and Flash 4D CTA using the high-pitch mode for the assessment of AD and to compare them with the standard triphasic protocol. Material and Methods A total of 54 consecutive patients were randomly and equally assigned to three groups and scanned with a second-generation DSCT scanner. Groups A, B, and C were assessed with the Dynamic 4D CTA in the shuttle mode, the Flash 4D CTA in the high-pitch mode, and the standard triphasic acquisition protocol, respectively. Image quality of all patients was evaluated. The effective radiation dose (ED) was recorded. Results In 54 patients, CTA images could display the true and false lumens, the intimal flap, the entry tear, and branch vessel involvement in the AD. Compared with group C, additional diagnostic information was obtained in groups A and B, including the dynamic enhancement delay between the true and false lumens (A = 18, B = 18); the presence of membrane oscillation (A = 8, B = 14); dynamic ejection of the contrast material from the true lumen into the false lumen (A = 6, B = 7); and the dynamic obstruction of the left renal artery (B = 2). The ED in these three groups was significantly different ( P < 0.05). Conclusion Compared to the standard triphasic protocol, the multiphase dynamic CTA protocol is feasible and is able to reveal additional diagnostic information. Therefore, we recommend using the high-pitch, dual-source multiphase dynamic CTA to assess ADs.
Definitions and participant characteristics of frequent recurrent headache types in clinical trials: A systematic review
Authors: Aguila Maria-Eliza R , Rebbeck Trudy , Mendoza Kristofferson G , De La Peña Mary-Grace L , Leaver Andrew M 
Published: April 2017

Background Clear definitions of study populations in clinical trials may facilitate application of evidence to clinical populations. This review aimed to explore definitions of study populations in clinical trials on migraine, tension-type headache, cluster headache, and cervicogenic headache. Methods We performed a systematic review of clinical trials investigating treatment efficacy for migraine, tension-type headache, cluster headache, and cervicogenic headache. We extracted data on diagnosis, inclusion criteria and baseline headache characteristics. Results Of the 229 studies reviewed, 205 studies (89.5%) defined their populations in adherence to the International Classification of Headache Disorders (ICHD) criteria. Some studies ( n = 127, 55.5%) specified diagnosing through interview, clinical examination and diary entry. The most commonly reported inclusion criteria were pain intensity for migraine and tension-type headache studies ( n = 123, 66.1% and n = 21, 67.7%, respectively), episode frequency ( n = 5, 71.4%) for cluster headache studies, and neck-related pain for cervicogenic headache studies ( n = 3, 60%). Few studies reported details on the extent to which diagnostic criteria were present at baseline. Conclusions ICHD is routinely used in defining populations in headache studies. Details of baseline headache characteristics were not as consistently reported.
Effectiveness of Neuromuscular Training Based on the Neuromuscular Risk Profile
Authors: Hewett Timothy E. , Ford Kevin R. , Xu Yingying Y. , Khoury Jane , Myer Gregory D. 
Published: April 2017

Background: The effects of targeted neuromuscular training (TNMT) on movement biomechanics associated with the risk of anterior cruciate ligament (ACL) injuries are currently unknown. Purpose/Hypotheses: To determine the effectiveness of TNMT specifically designed to increase trunk control and hip strength. The hypotheses were that (1) TNMT would decrease biomechanical and neuromuscular factors related to an increased ACL injury risk and (2) TNMT would decrease these biomechanical and neuromuscular factors to a greater extent in athletes identified as being at a high risk for future ACL injuries. Study Design: Controlled laboratory study. Methods: Female athletes who participated in jumping, cutting, and pivoting sports underwent 3-dimensional biomechanical testing before the season and after completing TNMT. During testing, athletes performed 3 different types of tasks: (1) drop vertical jump, (2) single-leg drop, and (3) single-leg cross drop. Analysis of covariance was used to examine the treatment effects of TNMT designed to enhance core and hip strength on biomechanical and neuromuscular characteristics. Differences were also evaluated by risk profile. Differences were considered statistically significant at P < .05. Results: TNMT significantly increased hip external rotation moments and moment impulses, increased peak trunk flexion, and decreased peak trunk extension. Athletes with a high risk before the intervention (risk profile III) had a more significant treatment effect of TNMT than low-risk groups (risk profiles I and II). Conclusion: TNMT significantly improved proximal biomechanics, including increased hip external rotation moments and moment impulses, increased peak trunk flexion, and decreased peak trunk extension. TNMT that focuses exclusively on proximal leg and trunk risk factors is not, however, adequate to induce significant changes in frontal-plane knee loading. Biomechanical changes varied across the risk profile groups, with higher risk groups exhibiting greater improvements in their biomechanics.
Serum carotenoid interactions in premenopausal women reveal α-carotene is negatively impacted by body fat
Authors: Nuss Emily Taylor , Valentine Ashley R , Zhang Zhumin , Lai HuiChuan Jennifer , Tanumihardjo Sherry A 
Published: April 2017

Increasing body mass indices (BMIs) across the globe reflect pandemic shifts towards habitual positive energy imbalances. Excess body fat in individuals is often associated with high-energy and high-fat diets scanty in fresh produce. Carotenoids are fat-soluble pigments plentiful in many fruits and vegetables. They are well-known for provitamin A and antioxidant functions, but little research has been done related to carotenoid-body mass interactions. Serum carotenoids were analyzed relative to body fat to determine correlations between major serum carotenoids, retinol, BMI, fat mass, and lean mass. Healthy women ( n = 76), 19–50 years old, were categorized into two comparison groups determined by percent body fat measured by air displacement plethysomography (BOD POD®), i.e. <31% and ≥31% fat mass. Anthropometric and three-day diet records were completed for BMI and nutrient intake calculations, respectively. Serum α-carotene concentrations were strongly inversely associated with all measures of body composition ( P < 0.001 α-carotene) controlling for dietary intake and age, while β-carotene, lutein, and lycopene were not ( P > 0.05). Dietary intake between groups did not differ, including carrot consumption (a high dietary source of α-carotene). These results confirm previous carotenoid-health research and propose the need for further investigation of potential protective roles that α-carotene may perform for optimal health. Serum α-carotene may provide a deeper and clinically relevant purpose, beyond previous suggestions for its use as a biomarker for fruit and vegetable consumption, in that α-carotene may be a biomarker for chronic disease risk frequently linked with obesity. Impact statement Carotenoids are important pigments in fruit and vegetables and found in human serum. This study isolated a negative relationship between serum α-carotene and body fatness. As humans begin to live over a century, determining biomarkers of ultimate health is important. α-Carotene does not have the same distribution in the food supply as β-carotene and therefore is often overlooked in surveys. In part, this is due to the fact that β-carotene provides two molecules of vitamin A, while α-carotene provides one upon central cleavage. This study shows a very clear association between α-carotene and body fatness, which appears to go beyond its fat-soluble nature. Dietary intake data were not able to explain the association. Further work is needed to determine what dietary components infer health benefits.
Patient-specific prediction of functional recovery after stroke
Authors: Douiri Abdel , Grace Justin , Sarker Shah-Jalal , Tilling Kate , McKevitt Christopher , Wolfe Charles DA , Rudd Anthony G 
Published: April 2017

Background and aims Clinical predictive models for stroke recovery could offer the opportunity of targeted early intervention and more specific information for patients and carers. In this study, we developed and validated a patient-specific prognostic model for monitoring recovery after stroke and assessed its clinical utility. Methods Four hundred and ninety-five patients from the population-based South London Stroke Register were included in a substudy between 2002 and 2004. Activities of daily living were assessed using Barthel Index) at one, two, three, four, six, eight, 12, 26, and 52 weeks after stroke. Penalized linear mixed models were developed to predict patients’ functional recovery trajectories. An external validation cohort included 1049 newly registered stroke patients between 2005 and 2011. Prediction errors on discrimination and calibration were assessed. The potential clinical utility was evaluated using prognostic accuracy measurements and decision curve analysis. Results Predictive recovery curves showed good accuracy, with root mean squared deviation of 3 Barthel Index points and a R2 of 83% up to one year after stroke in the external cohort. The negative predictive values of the risk of poor recovery (Barthel Index <8) at three and 12 months were also excellent, 96% (95% CI [93.6–97.4]) and 93% [90.8–95.3], respectively, with a potential clinical utility measured by likelihood ratios (LR+:17 [10.8–26.8] at three months and LR+:11 [6.5–17.2] at 12 months). Decision curve analysis showed an increased clinical benefit, particularly at threshold probabilities of above 5% for predictive risk of poor outcomes. Conclusions A recovery curves tool seems to accurately predict progression of functional recovery in poststroke patients.
Does increased standardisation in health care mean less responsiveness towards individual patients’ expectations? A register-based study in Swedish primary care
Authors: Glenngård Anna Häger , Anell Anders 
Published: April 2017

Objective: We explore whether standardisation in health care based on evidence on group level and a public health perspective is in conflict with responsiveness towards individual patient’s expectations in Swedish primary care. Methods: Using regression analysis, we study the association between patient views about providers’ responsiveness and indicators reflecting provider’s adherence to evidence-based guidelines, controlled for characteristics related to providers, including patient mix and degree of competition facing providers. Data were taken from two Swedish regions in years 2012 and 2013. Results: Patients’ views about responsiveness are positively correlated with variables reflecting provider’s adherence to evidence-based guidelines regarding treatment of elderly and risk groups, drug reviews and prescription of antibiotics. A high overall illness, private ownership and a high proportion of all visits being with a doctor are positively associated with patient views about responsiveness. The opposite relation was found for a high social deprivation among enrolled individuals and size of practice. There was no systematic variation with respect to the degree of competition facing providers. Conclusion: Results suggest that responsiveness towards individual patient expectations is compatible with increased standardisation in health care. This is encouraging for health care providers as they are challenged to balance increased demands from both patients and payers.
Does the method of “securing the catheter” make any difference?
Authors: Macneil James WH , Wilkins Rachel G , Taylor Russell P , Lau Howard M 
Published: April 2017

Objectives: The purpose of this study was to determine whether commonly used methods of securing an indwelling catheter decrease the force transmission along the indwelling catheter to the bladder neck in response to an externally applied force. Materials and methods: A test apparatus was constructed to simulate key features of a catheter drainage system. A “bladder neck” was suspended from a force gauge, with an indwelling catheter inserted through it, tensioned with a urine drainage bag. The system was calibrated, and various methods of securement were tested, with the level of force transmitted to the bladder neck recorded. The methods of securement tested included: adhesive tape taped used a number of ways (including direct taping and a taped mesentery), and three commercially available devices. Results: Some securement devices were able to completely eliminate force transmission to the bladder neck (the Flexi-Trak and Grip-Lok devices). A taped mesentery performed well reducing the transmitted force by up to 85% compared with an unsecured control. Conclusion: Within the limitations of this study we were able to demonstrate that some of the commonly used methods of securing indwelling catheters do work. We were also able to show that adhesive tape was still effective, although not as effective as commercially available devices.
Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice
Authors: Wang Chia-Yu , Core Amanda B. , Canali Susanna , Zumbrennen-Bullough Kimberly B. , Ozer Sinan , Umans Lieve , Zwijsen An , Babitt Jodie L. 
Published: April 2017

Key PointsThe presence of Smad1 or Smad5 in hepatocytes is sufficient to maintain iron homeostasis, whereas deficiency of both induces iron overload. Erythropoietin and erythroferrone fail to suppress hepcidin in mice with a conditional ablation of Smad1 and Smad5 in hepatocytes.
Effects of combined tiotropium/olodaterol on inspiratory capacity and exercise endurance in COPD
Authors: O'Donnell Denis E. , Casaburi Richard , Frith Peter , Kirsten Anne , De Sousa Dorothy , Hamilton Alan , Xue Wenqiong , Maltais François 
Published: April 2017

Two replicate, double-blind, 6-week, incomplete-crossover studies (MORACTO 1 and 2) assessed the effects of tiotropium/olodaterol on inspiratory capacity and exercise endurance time in patients with moderate to severe chronic obstructive pulmonary disease.For each patient, four of five treatments were administered once daily for 6 weeks, with a 21-day washout between treatments: tiotropium/olodaterol 2.5/5 µg or 5/5 µg, tiotropium 5 µg, olodaterol 5 µg or placebo, allviathe Respimat inhaler. Primary outcomes were inspiratory capacity prior to exercise and exercise endurance time during constant work-rate cycle ergometry to symptom limitation at 75% of peak incremental work rate after 6 weeks (2 h post-dose).295 and 291 patients were treated in MORACTO 1 and 2, respectively. Tiotropium/olodaterol 2.5/5 and 5/5 µg provided significant improvements in inspiratory capacityversusplacebo and monotherapies (p<0.0001), and significant improvements in exercise endurance timeversusplacebo (p<0.0001). Intensity of breathing discomfort was reduced following both doses of tiotropium/olodaterolversusplacebo (p<0.0001).Once-daily tiotropium/olodaterol yielded improvements in lung hyperinflationversusplacebo and statistically significant improvementsversusmonotherapies. Tiotropium/olodaterol also showed improvements in dyspnoea and exercise toleranceversusplacebo but not consistentlyversusmonotherapies.
Effect of pressure on 3D distribution of P-wave velocity and attenuation in antigorite serpentinite
Authors: Svitek Tomáš , Vavryčuk Václav , Lokajíček Tomáš , Petružálek Matěj , Kern Hartmut 
Published: April 2017

We have developed a detailed study on the pressure dependence of P-wave velocities and amplitudes on a spherical sample of antigorite serpentinite from Val Malenco, Northern Italy. Measurements were done at room temperature and hydrostatic pressures up to 400 MPa in a pressure vessel with oil as a pressure medium. The transducer/sample assembly allows simultaneous velocity and amplitude measurements on the spherical sample in 132 independent directions. Three significant directions of the foliated sample were selected to study changes of the directional dependence (anisotropy) of velocity, amplitude, and [Formula: see text]-factor with increasing pressure. Remarkable differences are observed between the changes of velocity and attenuation anisotropy as pressure is increased. Although the velocity anisotropy is quite stable through all pressure levels, the attenuation anisotropy and the [Formula: see text]-factor vary significantly in magnitude and orientation. The variations are probably caused by the closing of microcracks due to acting hydrostatic pressure, so the contact conditions between individual minerals consolidate and the transmitting energy is less attenuating.
Phase II Study of the Efficacy and Safety of Pembrolizumab for Relapsed/Refractory Classic Hodgkin Lymphoma
Authors: Chen Robert , Zinzani Pier Luigi , Fanale Michelle A. , Armand Philippe , Johnson Nathalie A. , Brice Pauline , Radford John , Ribrag Vincent , Molin Daniel , Vassilakopoulos Theodoros P. , Tomita Akihiro , von Tresckow Bastian , Shipp Margaret A. , Zhang Yinghua , Ricart Alejandro D. , Balakumaran Arun , Moskowitz Craig H. ,   for the KEYNOTE-087
Published: April 2017

Purpose Hodgkin Reed-Sternberg cells harbor alterations in chromosome 9p24.1, leading to overexpression of programmed death-ligand 1 (PD-L1) and PD-L2. Pembrolizumab, a programmed death 1–blocking antibody, demonstrated a high overall response rate (ORR) in patients with relapsed or refractory classic Hodgkin lymphoma (rrHL) in phase I testing. Methods KEYNOTE-087 ( ClinicalTrials.gov identifier, NCT02453594) was a single-arm phase II study of pembrolizumab in three cohorts of patients with rrHL, defined on the basis of lymphoma progression after (1) autologous stem cell transplantation (ASCT) and subsequent brentuximab vedotin (BV); (2) salvage chemotherapy and BV, and thus, ineligible for ASCT because of chemoresistant disease; and (3) ASCT, but without BV after transplantation. Patients received pembrolizumab 200 mg once every 3 weeks. Response was assessed every 12 weeks. The primary end points were ORR by central review and safety. Results A total of 210 patients were enrolled and treated (69 in cohort 1, 81 in cohort 2, and 60 in cohort 3). At the time of analysis, patients received a median of 13 treatment cycles. Per central review, the ORR was 69.0% (95% CI, 62.3% to 75.2%), and the complete response rate was 22.4% (95% CI, 16.9% to 28.6%). By cohort, ORRs were 73.9% for cohort 1, 64.2% for cohort 2, and 70.0% for cohort 3. Thirty-one patients had a response ≥ 6 months. The safety profile was largely consistent with previous pembrolizumab studies. Conclusion Pembrolizumab was associated with high response rates and an acceptable safety profile in patients with rrHL, offering a new treatment paradigm for this disease.
Second-Line Hormonal Therapy for Men With Chemotherapy-Naïve, Castration-Resistant Prostate Cancer: American Society of Clinical Oncology Provisional Clinical Opinion
Authors: Virgo Katherine S. , Basch Ethan , Loblaw D. Andrew , Oliver Thomas K. , Rumble R. Bryan , Carducci Michael A. , Nordquist Luke , Taplin Mary-Ellen , Winquist Eric , Singer Eric A. 
Published: April 2017

Purpose ASCO provisional clinical opinions (PCOs) offer direction to the ASCO membership after publication or presentation of potential practice-changing data. This PCO addresses second-line hormonal therapy for chemotherapy-naïve men with castration-resistant prostate cancer (CRPC) who range from being asymptomatic with only biochemical evidence of CRPC to having documented metastases but minimal symptoms. Clinical Context The treatment goal for CRPC is palliation. Despite resistance to initial androgen deprivation therapy, most men respond to second-line hormonal therapies. However, guidelines have neither addressed second-line hormonal therapy for nonmetastatic CRPC nor provided specific guidance with regard to the chemotherapy-naïve population. Recent Data Six phase III randomized controlled trials and expert consensus opinion inform this PCO. Provisional Clinical Opinion For men with CRPC, a castrate state should be maintained indefinitely. Second-line hormonal therapy (eg, antiandrogens, CYP17 inhibitors) may be considered in patients with nonmetastatic CRPC at high risk for metastatic disease (rapid prostate-specific antigen doubling time or velocity) but otherwise is not suggested. In patients with radiographic evidence of metastases and minimal symptoms, enzalutamide or abiraterone plus prednisone should be offered after discussion with patients about potential harms, benefits, costs, and patient preferences. Radium-223 and sipuleucel-T also are options. No evidence provides guidance about the optimal order of hormonal therapies for CRPC beyond second-line treatment. Prostate-specific antigen testing every 4 to 6 months is reasonable for men without metastases. Routine radiographic restaging generally is not suggested but can be considered for patients at risk for metastases or who exhibit symptoms or other evidence of progression. Additional information is available at www.asco.org/genitourinary-cancer-guidelines and www.asco.org/guidelineswiki .
The LXR Ligand T0901317 Acutely Inhibits Insulin Secretion by Affecting Mitochondrial Metabolism
Authors: Maczewsky Jonas , Sikimic Jelena , Bauer Cita , Krippeit-Drews Peter , Wolke Carmen , Lendeckel Uwe , Barthlen Winfried , Drews Gisela 
Published: April 2017

Abstract
The role of liver X receptor (LXR) in pancreatic β-cell physiology and pathophysiology is still unclear. It has been postulated that chronic LXR activation in β-cells induces lipotoxicity, a key step in the development of β-cell dysfunction, which accompanies type 2 diabetes mellitus. In most of these studies, the LXR ligand T0901317 has been administered chronically in the micromolar range to study the significance of LXR activation. In the current study, we have evaluated acute effects of T0901317 on stimulus-secretion coupling of β-cells. We found that 10 µM T0901317 completely suppressed oscillations of the cytosolic Ca2+ concentration induced by 15 mM glucose. Obviously, this effect was due to inhibition of mitochondrial metabolism. T0901317 markedly depolarized the mitochondrial membrane potential, thus inhibiting adenosine triphosphate (ATP) production and reducing the cytosolic ATP concentration. This led in turn to a huge increase in KATP current and hyperpolarization of the cell membrane potential. Eventually, T0901317 inhibited glucose-induced insulin secretion. These effects were rapid in on-set and not compatible with the activation of a nuclear receptor. In vivo, T0901317 acutely increased the blood glucose concentration after intraperitoneal application. In summary, these data clearly demonstrate that T0901317 exerts acute effects on stimulus-secretion coupling. This observation questions the chronic use of T0901317 and limits the interpretation of results obtained under these experimental conditions.