bluuebunny/crossref_metadata_2025_split huggingface dataset:
The urban geoarchaeology of Benevento, Southern Italy: Evaluating archaeological potential
Authors: Amato Vincenzo , Ciarcia Sabatino , Rossi Amedeo , Santoriello Alfonso 
Published: October 2017

AbstractThe city of Benevento in the southern Apennines is located on a Pleistocene fluvial terrace almost entirely bordered by rivers. Its ancient history of human settlements dates back to the Samnitic age (fifth to third centuries B.C.). The urban landscape witnessed extensive transformation, especially during the Roman (fourth century B.C.–sixth century A.D.) and Longobard (6th–10th centuries A.D.) periods, largely as a result of destructive earthquakes and massive floods. As a consequence, large portions of the modern town were built on deep stratified archeological deposits that partially preserve the remains of previous settlements. In order to improve and expand our knowledge of the buried archaeological heritage of this town, archaeo‐stratigraphic data were integrated into a geographic information system format and database, the latter further supplemented by a detailed geomorphological study. This new dataset enabled a reassessment of the Benevento subsurface along with its archaeological assets, shedding new light on the archaeological potential of the urban area. Finally, a more reliable map of hidden cultural resources was developed, thus providing a useful tool for more suitable urban planning and project designs to help guide renovation of urban infrastructure.
Enhanced hepatogenic differentiation of bone marrow derived mesenchymal stem cells on liver ECM hydrogel
Authors: Wang Bo , Li Wuwei , Dean Derrick , Mishra Manoj K. , Wekesa Kennedy S. 
Published: October 2017

AbstractBone marrow derived mesenchymal stem cells (BM‐MSC) is a promising alternative cell source to primary hepatocytes because of their ability to differentiate into hepatocyte‐like cells. However, their inability to differentiate efficiently and potential to turn into myofibroblasts restrict their applications. This study developed a plate coating from the liver extracellular matrix (ECM) and investigated its ability in facilitating the BM‐MSCs proliferation, hepatic differentiation, and hepatocyte‐specific functions during in vitro culture. After 28‐day culture, BM‐MSCs on the ECM coating showed hepatocyte‐like morphology, and certain cells took up low‐density lipoprotein. Synthesis of albumin, urea, and anti‐alpha‐fetoprotein, as well as expression of certain hepatic markers, in cells cultured on ECM were higher than cells cultured on non‐coated and Matrigel‐coated plates. mRNA levels of CYP3A4, albumin, CK18, and CYP7A1 in cells on ECM coating were significantly higher than cells cultured on the non‐coating environment. In conclusion, viability and hepatogenic differentiation of BM‐MSCs cultured on both Matrigel and ECM coating were significantly enhanced compared with those cultured on non‐coated plates. Moreover, the liver ECM coating induced additional metabolic functions relative to the Matrigel coating. The liver ECM hydrogel preserves the natural composition, promotes simple gelling, induces efficient stem cell hepatogenic differentiation, and may have uses as an injectable intermedium for hepatocytes. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 829–838, 2018.
Hypophosphatemia, Severe Bone Pain, Gait Disturbance, and Fatigue Fractures After Iron Substitution in Inflammatory Bowel Disease: A Case Report
Authors: Bartko Johann , Roschger Paul , Zandieh Shahin , Brehm Attila , Zwerina Jochen , Klaushofer Klaus 
Published: October 2017

ABSTRACT

Intravenous infusions of different iron formulations are recognized as a cause of hypophosphatemia. Chronic hypophosphatemia can alter bone metabolism and bone material structure. As a consequence, osteomalacia may develop and lead to bone fragility. Herein, we report a patient with Crohn's disease presenting with persistent hypophosphatemia and insufficiency fractures while receiving regular iron infusions due to chronic gastrointestinal bleeding. Previously, the patient regularly received vitamin D and also zoledronic acid. The patient underwent bone biopsy of the iliac crest that showed typical signs of osteomalacia with dramatically increased osteoid volume and decreased bone formation. Analysis of the bone mineralization density distribution (BMDD) revealed a more complex picture: On the one hand, there was a shift to higher matrix mineralization, presumably owing to low bone turnover; on the other hand, a broadening of the BMDD indicating more heterogeneous mineralization due to osteomalacia was also evident. This is the first report on changes of bone histomorphometry and bone matrix mineralization in iron-induced osteomalacia. © 2017 American Society for Bone and Mineral Research.
New lower bounds for t‐coverings
Authors: Horsley Daniel , Singh Rakhi 
Published: October 2017

AbstractFisher proved in 1940 that any 2‐ design with has at least v blocks. In 1975, Ray‐Chaudhuri and Wilson generalized this result by showing that every t‐ design with has at least blocks. By combining methods used by Bose and Wilson in proofs of these results, we obtain new lower bounds on the size of t‐ coverings. Our results generalize lower bounds on the size of 2‐ coverings recently obtained by the first author.
Qualitative analysis of multiple compounds in raw and prepared Semen Cassiae coupled with multiple statistical strategies
Authors: Yang Bing , Hu Jing , Zhu Xiaochai , Zhuang Yanshuang , Yin Fangzhou , Qin Kunming , Cai Baochang 
Published: October 2017

AbstractIn China, Semen Cassiae is used clinically to improve eyesight, relieve constipation, and to treat headache and dizziness. Prepared Semen Cassiae is obtained by stir‐frying raw Semen Cassiae until it turned dark brown, micro dilatancy, and overflow aroma. After processing, the therapeutic effects change—the purgation effect is alleviated and the hepatoprotective effect is enhanced. To explore the changes in chemical compositions of Semen Cassiae after processing and clarify the material basis of the changed therapeutic effects, an ultra‐high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry coupled with automated data analysis software and statistical strategy was developed. As a result, 53 compounds in raw Semen Cassiae and 43 compounds in prepared Semen Cassiae were found, a total of 55 chemical compounds were identified. Principle component analysis and t‐test were processed by Markerview 1.2.1 software. Finally, 39 peaks were found to be the main contributors to the significant difference (p < 0.05) between raw and prepared Semen Cassiae. Compared with raw Semen Cassiae, 19 peaks showed a higher intensity in prepared Semen Cassiae, while the contents of 20 compounds in prepared Semen Cassiae were lower, most of which belonged to naphthopyrones glycosides and anthraquinone glycosides.
Cisplatin‐Rich Polyoxazoline–Poly(aspartic acid) Supramolecular Nanoparticles
Authors: Zhang Peng , Yuan Kangjun , Li Cheng , Zhang Xiaoke , Wu Wei , Jiang Xiqun 
Published: October 2017

AbstractCisplatin‐rich supramolecular nanoparticles are constructed through the supramolecular inclusion interaction between the admantyl (Ad)‐terminated poly(aspartic acid) (Ad‐P(Asp)) and the β‐cyclodextrin (β‐CD)‐terminated poly(2‐methyl‐2‐oxazoline). In the formation of the nanoparticles, the β‐CD/admantane inclusion complex integrates poly(2‐methyl‐2‐oxazoline) and poly(aspartic acid) chains to form pseudoblock copolymers, followed by the coordination between carboxyl groups in P(Asp) block and cisplatin. This coordination interaction drives the formation of nanoparticle and enables cisplatin incorporated into the nanoparticles. The spherical cisplatin‐rich supramolecular nanoparticles have 53% cisplatin‐loading content, good stability, and effective inhibition of the cell proliferation when it is tested in H22 cancer cells. Near‐infrared fluorescence imaging of tumor bearing mice reveals that the cisplatin‐rich nanoparticles can target the tumor in vivo effectively.
MolProbity: More and better reference data for improved all‐atom structure validation
Authors: Williams Christopher J. , Headd Jeffrey J. , Moriarty Nigel W. , Prisant Michael G. , Videau Lizbeth L. , Deis Lindsay N. , Verma Vishal , Keedy Daniel A. , Hintze Bradley J. , Chen Vincent B. , Jain Swati , Lewis Steven M. , Arendall W. Bryan , Snoeyink Jack , Adams Paul D. , Lovell Simon C. , Richardson Jane S. , Richardson David C. 
Published: October 2017

AbstractThis paper describes the current update on macromolecular model validation services that are provided at the MolProbity website, emphasizing changes and additions since the previous review in 2010. There have been many infrastructure improvements, including rewrite of previous Java utilities to now use existing or newly written Python utilities in the open‐source CCTBX portion of the Phenix software system. This improves long‐term maintainability and enhances the thorough integration of MolProbity‐style validation within Phenix. There is now a complete MolProbity mirror site at http://molprobity.manchester.ac.uk. GitHub serves our open‐source code, reference datasets, and the resulting multi‐dimensional distributions that define most validation criteria. Coordinate output after Asn/Gln/His “flip” correction is now more idealized, since the post‐refinement step has apparently often been skipped in the past. Two distinct sets of heavy‐atom‐to‐hydrogen distances and accompanying van der Waals radii have been researched and improved in accuracy, one for the electron‐cloud‐center positions suitable for X‐ray crystallography and one for nuclear positions. New validations include messages at input about problem‐causing format irregularities, updates of Ramachandran and rotamer criteria from the million quality‐filtered residues in a new reference dataset, the CaBLAM Cα‐CO virtual‐angle analysis of backbone and secondary structure for cryoEM or low‐resolution X‐ray, and flagging of the very rare cis‐nonProline and twisted peptides which have recently been greatly overused. Due to wide application of MolProbity validation and corrections by the research community, in Phenix, and at the worldwide Protein Data Bank, newly deposited structures have continued to improve greatly as measured by MolProbity's unique all‐atom clashscore.
Dual‐rate sampled‐data stabilization for active suspension system of electric vehicle
Authors: Meng Qinghua , Qian Chunjiang , Liu Rongjie 
Published: October 2017

SummaryIn this paper, we consider the dual‐rate sampled‐data state‐feedback control problem for an active suspension system of an electric vehicle. In the active suspension system, there exist 2 accelerometers to measure the heave acceleration of the sprung mass and the vertical acceleration of the unsprung mass, respectively. When the 2 accelerations are measured by sampled data under different sampling periods, the difficulty arising from the dual‐rate sampled data makes the active suspension stabilization problem challenging but interesting. In this paper, a linear hybrid stabilizer is proposed, which is implemented using dual‐rate sampled‐data state feedback. In order to deal with the more difficult stabilization problem under different triggering time instants, a coordinate transformation is proposed. A useful technical theorem is proposed in the stability analysis to show that the proposed hybrid controller can guarantee the states of the active suspension system being asymptotically stabilized or at least bounded to arbitrarily small domains. The experiment result is similar to the simulation result and indicates that the proposed active suspension controlling system is effective.
Experimental and Theoretical Efforts to Identify the Microstructural Transition of Water to Acetonitrile‐Based Reverse Micelle through Binary Compositions of Polar Solvents
Authors: Chowdhury Madhurima Paul , Kundu Kaushik , Bardhan Soumik , Kar Barnali , Chakraborty Gulmi , Saha Swapan K. 
Published: October 2017

AbstractThe present report was undertaken due to the scarcity of information regarding the microstructural transition from aqueous to acetonitrile (ACN)‐based non‐aqueous reverse micelles (RMs) stabilized by cationic didodecyldimethylammonium bromide (DDAB) and anionic sodium bis(2‐ethylhexyl) sulfosuccinate (AOT) in cyclohexane. The synergistic solubilization capacity of corresponding polar solvent at a fixed composition and the nature of conductance plots in these RMs were markedly varied along with the composition of binary solvents (water and ACN at pure or mixed states) and the surfactant charge types (DDAB and AOT). The structural alteration in these RMs through water‐ and ACN‐rich compositions were studied by FTIR, where the results were explained in terms of molecular states of water and ACN inside RMs. The differential binding affinity of both polar solvents with the two surfactants was shown using ab initio calculations. The subsequent appearance and disappearance of aqueous nano‐pool was verified from UV‐Vis technique using CoCl2. The lack of H‐bonding ability on going from aqueous to ACN‐based RMs was evidenced from the temperature‐dependent DLS study along with the absorption profiles of 7‐hydroxycoumarin. The results showed how the microstructures and H‐bonding interactions inside RMs are dramatically altered by simply changing polarity of the solvents or the surfactant charge‐types. This report could be useful to understand the formation mechanism of two class of RMs.
Main air pollutants and ventricular arrhythmias in patients with implantable cardioverter‐defibrillators: A systematic review and meta‐analysis
Authors: Yang Hong‐Jie , Liu Xin , Qu Chuan , Shi Shao‐Bo , Liang Jin‐Jun , Yang Bo 
Published: October 2017

AbstractObjectivePrevious studies of ambient air pollutants and ventricular arrhythmias in patients with implantable cardioverter‐defibrillator (ICD) have yielded mixed results, and the association between air pollution and ventricular arrhythmias in these patients remains unclear. This study aimed to assess and quantify the association between exposure to major air pollutants [CO, inhalable particles (PM10), SO2, fine particulate matter (PM2.5), O3, and NO2] and the presence of ventricular arrhythmia in patients with ICD.MethodsThe Medline, PubMed, Web of Science, Global Health Library, Virtual Health Library, Population Information Online (POPLINE), and New York Academy of Medicine Grey Literature Report databases were searched to identify studies analyzing the association between ventricular arrhythmias in patients with ICD and the abovementioned main air pollutants. Pooled estimates were generated using a random‐effects model or fixed‐effects model, according to the value of heterogeneity. Heterogeneity within studies was assessed using Cochran's Q and I2 statistics. Funnel plots, Egger's regression test, and Begg's rank correlation method were used to evaluate publication bias. Sensitivity analyses were also conducted to evaluate the potential sources of heterogeneity.ResultsAfter a detailed screening of 167 studies, seven separate studies were identified. Ventricular arrhythmias in patients with ICD were found to be positively, but not significantly, associated with CO, PM10, SO2, PM2.5, and NO2, with a pooled estimate [odds ratio (OR) associated with each 10 μg/m3 increase in pollutant concentration, except for CO, which was associated with each 1 mg/m3 increase in concentration] of 1.03 [95% confidence interval (CI): 0.92–1.17, P = 0.59] for CO, 1.01 (95%CI: 0.97–1.05, P = 0.55) for PM10, 1.09 (95%CI: 0.95–1.24, P = 0.22) for SO2, 1.07 (95%CI: 0.95–1.21, P = 0.25) for PM2.5, and 1.06 (95%CI: 0.98–1.14, P = 0.16) for NO2. No increased risk of ventricular arrhythmias in patients with ICD was found to be associated with O3 (OR = 1.00; 95%CI: 0.98–1.01, P = 0.56).ConclusionsThe results of this study provide little evidence that ambient air pollutants affect the risk of ICD discharges for treating ventricular arrhythmias.
FREDERICK THE GREAT AND JEAN LE ROND D'ALEMBERT ON PHILOSOPHY, TRUTH, AND POLITICS
Authors: LIM SHIRU 
Published: October 2017

AbstractThe prize question of the Berlin Academy of Sciences for 1780, on the utility of deception, has attracted both controversy and scholarly interest. Yet very little attention has been dedicated to the question's peculiar beginnings in the correspondence between the philosopher and mathematician Jean Le Rond d'Alembert and Frederick the Great, king of Prussia, in a discussion concerning the expulsion of the Jesuits from France. This correspondence not only reveals the prize question's complex genealogy in long-standing debates on the true ends of philosophy, but also helps revise conventional frameworks for understanding the relationship between philosophy and politics in Enlightenment Europe. Far from an adornment intended to boost the ‘Enlightened’ credentials of an absolutist king, d'Alembert held the momentum in this relationship, and recruited Frederick to his own campaign of promoting publicly useful philosophy. ‘Philosophy’ here amounted to a commitment to the truth and its public defence, rather than subscription to or belief in a specific set of ideas or political reforms. Placing pressure on rulers to disavow deceitful politics, the far-reaching implications of this conception of philosophy for political life were no less ambitious than the agendas espoused by protagonists of a supposed ‘radical Enlightenment’.
PERFORMANCE OF OVID MEDLINE SEARCH FILTERS TO IDENTIFY HEALTH STATE UTILITY STUDIES
Authors: Arber Mick , Garcia Sonia , Veale Thomas , Edwards Mary , Shaw Alison , Glanville Julie M. 
Published: October 2017

Objectives: This study was designed to assess the sensitivity of three Ovid MEDLINE search filters developed to identify studies reporting health state utility values (HSUVs), to improve the performance of the best performing filter, and to validate resulting search filters.Methods: Three quasi-gold standard sets (QGS1, QGS2, QGS3) of relevant studies were harvested from reviews of studies reporting HSUVs. The performance of three initial filters was assessed by measuring their relative recall of studies in QGS1. The best performing filter was then developed further using QGS2. This resulted in three final search filters (FSF1, FSF2, and FSF3), which were validated using QGS3.Results: FSF1 (sensitivity maximizing) retrieved 132/139 records (sensitivity: 95 percent) in the QGS3 validation set. FSF1 had a number needed to read (NNR) of 842. FSF2 (balancing sensitivity and precision) retrieved 128/139 records (sensitivity: 92 percent) with a NNR of 502. FSF3 (precision maximizing) retrieved 123/139 records (sensitivity: 88 percent) with a NNR of 383.Conclusions: We have developed and validated a search filter (FSF1) to identify studies reporting HSUVs with high sensitivity (95 percent) and two other search filters (FSF2 and FSF3) with reasonably high sensitivity (92 percent and 88 percent) but greater precision, resulting in a lower NNR. These seem to be the first validated filters available for HSUVs. The availability of filters with a range of sensitivity and precision options enables researchers to choose the filter which is most appropriate to the resources available for their specific research.
Pulse therapy combined with oral corticosteroids in the management of severe rheumatic carditis and rebound
Authors: Torres Renato P. A. , Torres Rômulo F. A. , Torres Rafael A. , Torres Rosângela S. L. A. 
Published: October 2017

AbstractObjectiveThe aim of the present study was to describe the clinical course, laboratory tests, and the cardiac involvement in rheumatic carditis patients in functional class III and IV, submitted to pulse therapy combined with oral prednisone.MethodsA total of 120 patients with severe carditis due to acute rheumatic fever were treatment with three cycles of pulse therapy combined with oral corticosteroids. The patients were followed up from the hospital admission until the end of the treatment and returned after 30, 60, and 90 days to control. The patients were evaluated by clinical, laboratory, and transthoracic echocardiogram.ResultsIn total, 23 (19.2%) patients at first attack of rheumatic fever and 97 (80.8%) with recurrent carditis were evaluated. Cardiac surgery was performed in 8 (6.6%) patients. The patients showed improved laboratory and radiological parameters (p<0.001) and were discharged, 74 (61.7%) in functional class I and 46 (38.3%) in functional class II. Hospitalisation time ranged from 21 to 176 days, with a mean of 69.1 days. Reduction of left atrium and ventricle diameters was observed, measured by means of transthoracic echocardiography, at hospital admission and discharge (p<0.001). None of the patients experienced rebound.ConclusionsThe pulse therapy was effective in controlling severe rheumatic carditis and the oral corticosteroid prevented rebound episodes. Prolonged hospital stay was required for the clinical stabilisation of patients and to avoid the interruption of medication.
Comparison of the Optical Properties of Graphene and Alkyl-terminated Si and Ge Quantum Dots
Authors: de Weerd Chris , Shin Yonghun , Marino Emanuele , Kim Joosung , Lee Hyoyoung , Saeed Saba , Gregorkiewicz Tom 
Published: October 2017

AbstractSemiconductor quantum dots are widely investigated due to their size dependent energy structure. In particular, colloidal quantum dots represent a promising nanomaterial for optoelectronic devices, such as photodetectors and solar cells, but also luminescent markers for biotechnology, among other applications. Ideal materials for these applications should feature efficient radiative recombination and absorption transitions, altogether with spectral tunability over a wide range. Group IV semiconductor quantum dots can fulfill these requirements and serve as an alternative to the commonly used direct bandgap materials containing toxic and/or rare elements. Here, we present optical properties of butyl-terminated Si and Ge quantum dots and compare them to those of graphene quantum dots, finding them remarkably similar. We investigate their time-resolved photoluminescence emission as well as the photoluminescence excitation and linear absorption spectra. We contemplate that their emission characteristics indicate a (semi-) resonant activation of the emitting channel; the photoluminescence excitation shows characteristics similar to those of a molecule. The optical density is consistent with band-to-band absorption processes originating from core-related states. Hence, these observations strongly indicate a different microscopic origin for absorption and radiative recombination in the three investigated quantum dot systems.