bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast parenchymal patterns in processed versus raw digital mammograms: A large population study toward assessing differences in quantitative measures across image representations
Authors: Gastounioti Aimilia , Oustimov Andrew , Keller Brad M. , Pantalone Lauren , Hsieh Meng‐Kang , Conant Emily F. , Kontos Despina 
Published: October 2016

PurposeWith raw digital mammograms (DMs), which retain the relationship with x‐ray attenuation of the breast tissue, not being routinely available, processed DMs are often the only viable means to acquire imaging measures. The authors investigate differences in quantitative measures of breast density and parenchymal texture, shown to have value in breast cancer risk assessment, between the two DM representations.MethodsThe authors report data from 8458 pairs of bilateral raw (“FOR PROCESSING”) and processed (“FOR PRESENTATION”) DMs acquired from 4278 women undergoing routine screening evaluation, collected with DM units from two different vendors. Breast dense tissue area and percent density (PD), as well as a range of quantitative descriptors of breast parenchymal texture (statistical, co‐occurrence, run‐length, and structural descriptors), were measured using previously validated, fully automated software. Feature measurements were compared using matched‐pairs Wilcoxon signed‐ranks test, correlation (r), and linear‐mixed‐effects (LME) models, where potential interactions with woman‐ and system‐specific factors were also assessed. The authors also compared texture feature correlations with the established risk factors of the Gail lifetime risk score (rG) and breast PD (rPD), and evaluated the within woman intraclass feature correlation (ICC), a measure of bilateral breast‐tissue symmetry, in raw versus processed images.ResultsAll density measures and most of the texture features were strongly (r ≥ 0.6) or moderately (0.4 ≤ r < 0.6) correlated between raw and processed images. However, measurements were significantly different between the two imaging formats (Wilcoxon signed‐ranks test, pw < 0.05). The association between measurements varied across features and vendors, and was substantially modified by woman‐ and system‐specific image acquisition factors, such as age, BMI, and mAs/kVp, respectively. The strongest correlation, combined with minimal LME‐model interactions, was observed for structural texture features. Overall, texture measures from either image representation were weakly associated with Gail lifetime risk (−0.2 ≤ rG ≤ 0.2), weakly to moderately associated with breast PD (−0.6 ≤ rPD ≤ 0.6), and had overall strong bilateral symmetry (ICC ≥ 0.6).ConclusionsDifferences in measures from processed versus raw DM depend highly on the feature, the DM vendor, and image acquisition settings, where structural features appear to be more robust across the different DM settings. The reported findings may serve as a reference in the design of future large‐scale studies on mammographic features and breast cancer risk assessment involving multiple DM representations.
The Role of Interaction Patterns with Hybrid Electric Vehicle Eco-Features for Drivers’ Eco-Driving Performance
Authors: Arend Matthias G. , Franke Thomas 
Published: October 2016

Objective: The objective of the present research was to understand drivers’ interaction patterns with hybrid electric vehicles’ (HEV) eco-features (electric propulsion, regenerative braking, neutral mode) and their relationship to fuel efficiency and driver characteristics (technical system knowledge, eco-driving motivation). Background: Eco-driving (driving behaviors performed to achieve higher fuel efficiency) has the potential to reduce CO2 emissions caused by road vehicles. Eco-driving in HEVs is particularly challenging due to the systems’ dynamic energy flows. As a result, drivers are likely to show diverse eco-driving behaviors, depending on factors like knowledge and motivation. The eco-features represent an interface for the control of the systems’ energy flows. Method: A sample of 121 HEV drivers who had constantly logged their fuel consumption prior to the study participated in an online questionnaire. Results: Drivers’ interaction patterns with the eco-features were related to fuel efficiency. A common factor was identified in an exploratory factor analysis, characterizing the intensity of actively dealing with electric energy, which was also related to fuel efficiency. Driver characteristics were not related to this factor, yet they were significant predictors of fuel efficiency. Conclusion: From the perspective of user–energy interaction, the relationship of the aggregated factor to fuel efficiency emphasizes the central role of drivers’ perception of and interaction with energy conversions in determining HEV eco-driving success. Application: To arrive at an in-depth understanding of drivers’ eco-driving behaviors that can guide interface design, authors of future research should be concerned with the psychological processes that underlie drivers’ interaction patterns with eco-features.
LXR agonist treatment of blastic plasmacytoid dendritic cell neoplasm restores cholesterol efflux and triggers apoptosis
Authors: Ceroi Adam , Masson David , Roggy Anne , Roumier Christophe , Chagué Cécile , Gauthier Thierry , Philippe Laure , Lamarthée Baptiste , Angelot-Delettre Fanny , Bonnefoy Francis , Perruche Sylvain , Biichle Sabeha , Preudhomme Claude , Macintyre Elisabeth , Lagrost Laurent , Garnache-Ottou Francine , Saas Philippe 
Published: October 2016

Key PointsLXR activation inhibits BPDCN cell survival through the increase of cholesterol efflux, the inhibition of NF-κB, and IL-3 signaling. Treatment with LXR agonists can be proposed as a new therapeutic approach for BPDCN.
The Potential of Outsourcing Development as a HR Technology in the Stavropol Region
Authors: Мухорьянова  , Mukhoryanova O. , Астахова  , Astakhova E. , Калюгина  , Kalyugina Svetlana , Кривокора  , Krivokora Yevgyeniya , Савченко  , Savchenko I. 
Published: October 2016

The article describes the content and types of outsourcing, investigated its benefits. The evaluation of the practice of outsourcing both HR technology in Russia based
on the analysis of open official sources, are examples of successful domestic outsourcing projects. Consistent with the task of research focuses on the development
of the outsourcing of technology in government, examines the key challenges and problems faced by the authorities in the implementation of the outsourcing on the
municipal level. The main focus of the research is done on the possibilities of increased efficiency through the creation of jobs, development of territories, securing
their own staff and attracting new human resources with a high level of professional competence. The experience of Russian regions is studied in detail, the main
problems in the introduction of outsourcing in the Stavropol region are highlighted and „road map« of outsourcing in the Stavropol region is proposed.
Linear ubiquitination by LUBEL has a role in Drosophila heat stress response
Authors: Asaoka Tomoko , Almagro Jorge , Ehrhardt Christine , Tsai Isabella , Schleiffer Alexander , Deszcz Luiza , Junttila Sini , Ringrose Leonie , Mechtler Karl , Kavirayani Anoop , Gyenesei Attila , Hofmann Kay , Duchek Peter , Rittinger Katrin , Ikeda Fumiyo 
Published: October 2016

AbstractThe HOIP ubiquitin E3 ligase generates linear ubiquitin chains by forming a complex with HOIL‐1L and SHARPIN in mammals. Here, we provide the first evidence of linear ubiquitination induced by a HOIP orthologue in Drosophila. We identify Drosophila CG11321, which we named Linear Ubiquitin E3 ligase (LUBEL), and find that it catalyzes linear ubiquitination in vitro. We detect endogenous linear ubiquitin chain‐derived peptides by mass spectrometry in Drosophila Schneider 2 cells and adult flies. Furthermore, using CRISPR/Cas9 technology, we establish linear ubiquitination‐defective flies by mutating residues essential for the catalytic activity of LUBEL. Linear ubiquitination signals accumulate upon heat shock in flies. Interestingly, flies with LUBEL mutations display reduced survival and climbing defects upon heat shock, which is also observed upon specific LUBEL depletion in muscle. Thus, LUBEL is involved in the heat response by controlling linear ubiquitination in flies.
KEBIJAKAN PENGOPERASIAN BUBU DENGAN ALAT BANTU TERUMBU KARANG BUATAN DAN RUMPON DI WILAYAH REHABILITASI PERAIRAN KEPULAUAN SERIBU
Authors: Edrus Isa Nagib 
Published: October 2016

<p>Ujicoba bubu bersama terumbu karang buatan dan rumpon di wilayah rehabilitasi perairan Pulau Pari dan Pramuka adalah untuk menentukan kesesuaian paket teknologi alat tangkap dan alat bantu dalam usaha perikanan yang layak dari sisi teknis, sosial dan ekonomi. Tulisan ini merupakan sintesa kebijakan pola pemanfaatan bubu dengan dua alat bantu pengumpul ikan. Pendekatan yang digunakan adalah analisis kebijakan dengan memformulasikan semua informasi yang relevan dan hasil penelitian terkait. Hasil analisis menunjukkan bahwa penggunaan bubu dalam perikanan multi alat tangkap dengan pemanfaatan alat bantu penangkapan tergolong efektif secara teknis, sosial dan ekonomis. CPUE bubu dari 4 hari perendaman/trip adalah ratarata 1,1 kg/unit/trip untuk nelayan Pulau Pari yang mengoperasikan bubu di dekat terumbu buatan dan 2,4 kg/unit/trip untuk nelayan Pulau Pulau Pramuka yang menaruh bubu di bawah rumpon. Perikanan bubu tergolong layak ekonomi jika terintegrasi dengan perikanan multi alat tangkap. Nilai tambah pendapatan dari penggunaan bubu berkisar pada Rp. 196.000–Rp. 400.000 per trip. Perikanan bubu memiliki prospek yang baik untuk dikembangkan dalam skala besar melalui diversifikasi usaha perikanan di wilayah perairan yang direhabilitasi dan aplikasinya dapat diterima nelayan. Alat bantu rumpon memberikan pengaruh lebih besar pada hasil tangkap bubu dibanding hanya penggunaan karang buatan.</p><p> </p><p>The pot application by using artificial reefs and payaos as rehabilited fishing grounds in the waters of Pari and Pramuka Islands was to determine technological, social and economical feasible fisheries used pots and the both of fish aggregation divices (FAD). This paper is policy making of pot utility design using two kinds of the FAD. Policy analysis is an approach used to formulate any relevant information and related study results. The analysis showed that pot applications in multi gears fisheries using FAD were effective by technical, social and economical senses. Cacth Per Unit of Effort (CPUE) average of pots set 4 days per trip in the adjacent area of artificial reefs by the Pari island fisherfolks was 1.1 kg/unit/trip and those were operated under payaos by Pramuka Island fisherfolks was 2.4 kg/unit/trip. Pot fishery was feasible economic if it’s fishing had been integrated with multi gear fishery. Added values of the pot fishing income ranged from Rp. 196,000 to Rp. 400,000 per fishing trip. Pot fishery was propective to be intensively developed throught diversity fisheries in rehabilited water regions and it’s application get fisherfolk positive responses.</p>
TEKNOLOGI PRODUKSI INTENSIF TOKOLAN UDANG WINDU (Penaeus monodon Fabr.) DI TAMBAK DENGAN SISTEM AERASI
Authors: Suwoyo Hidayat Suryanto , Mangampa Markus 
Published: October 2016

Sampai saat ini udang masih merupakan komoditas andalan untuk meningkatkan devisa ekspor non-migas. Namun masalah penyakit masih menjadi kendala utama yang dihadapi petambak, sementara cara penanggulangan yang efektif belum ditemukan. Salah satu alternatif yang terus dikaji dan dikembangkan untuk menanggulangi penyakit adalah melalui penggunaan benur berkualitas. Mutu benur dan kesalahan manajemen pakan dapat diatasi dengan penggunaan benur hasil pentokolan. Pentokolan dengan sistem aerasi merupakan salah satu alternatif. Keuntungan pentokolan ini adalah dapat diperoleh benur yang berkualitas tinggi sehingga meningkatkan vitalitas benur, yang akhirnya dapat meningkatkan produktivitas tambak, efisiensi penggunaan pakan, wadah dan pengelolaan, mempersingkat waktu pemeliharaan, sehingga mengurangi peluang terserangnya penyakit. Sintasan tokolan dihasilkan dengan sistem aerasi ini dapat mencapai sekitar 82,65%--92,36% dengan rata-rata 85,79% dan bobot akhir berkisar antara 0,229--0,331 g/ekor.
DESAIN, TATA LETAK, DAN KONSTRUKSI TAMBAK
Authors: Mustafa Akhmad 
Published: October 2016

Komoditas yang umum dibudidayakan di tambak Indonesia adalah udang dan ikan bandeng yang menjadi komoditas unggulan untuk dikembangkan. Salah satu faktor penting yang sangat menentukan keberhasilan usaha budidaya tambak adalah rekayasa tambak yang mencakup disain, tata letak, dan konstruksi tambak. Secara umum, desain petakan tambak merupakan perencanaan bentuk tambak yang meliputi: ukuran panjang dan lebar petakan, kedalaman, ukuran pematang, ukuran berm, dan ukuran saluran keliling, serta ukuran dan letak pintu air. Tata letak suatu unit tambak harus memenuhi tujuan seperti: menjamin kelancaran mobilitas operasional sehari-hari, menjamin kelancaran dan keamanan pasok air, serta pembuangannya, dapat menekan biaya konstruksi tanpa mengurangi fungsi teknis dari unit tambak yang dibangun dan mempertahankan kelestarian lingkungan. Konstruksi tambak yang menggambarkan proses pengerjaan tambak harus disesuaikan dengan desain dan tata letak yang telah ada. Rekayasa tambak diarahkan pada kemampuan untuk menciptakan kondisi yang sesuai dengan keadaan alami yang dituntut oleh organisme akuatik yang dibudidayakan sehingga produktivitas tambak meningkat, efisien secara ekonomis, dan berkelanjutan.
PRESENT STATUS PRODUKSI DAN BUDIDAYA TERIPANG DI SULAWESI SELATAN
Authors: Tangko Abdul Malik 
Published: October 2016

Di Sulawesi Selatan teripang diperdagangkan dan diekspor ke Cina sejak abad ke-17 dan pada tahun 1824 berhasil mengekspor teripang sebanyak 300 ton dengan nilai 350.000 gulden atau setara 7.500.000 US Dollar. Kegiatan perburuan teripang oleh pelaut Bugis-Makassar di Australia Utara berlangsung sejak pada abad ke-17 dan berakhir pada tahun 1910. Setelah itu, wilayah operasi penangkapannya hanya meliputi perairan Sulawesi Selatan dan sekitarnya. Pada tahun 2004 volume ekspor teripang Sulawesi Selatan mencapai 1.052,5 ton dengan nilai 94.450.650 US Dollar kemudian mengalami penurunan menjadi 734,0 ton dengan nilai 15.805.120 US Dollar pada tahun 2007. Penurunan produksi teripang ini disebabkan karena populasinya di alam semakin berkurang, sedangkan harga dan permintaan pasar ekspor semakin meningkat. Pada saat ini harga teripang di Sulawesi Selatan mencapai Rp150.000,00-Rp500.000,00/kg. Sedangkan peningkatan produksi melalui usaha budidaya belum bisa berkembang walaupun teknologinya sudah dikuasai dan dukungan sumberdaya lahan yang cukup luas. Hal ini disebabkan oleh keterbatasan benih yang hanya mengandalkan benih dari alam yang bersifat musiman, sedangkan usaha pembenihan teripang di Indonesia termasuk di Sulawesi Selatan belum dapat berproduksi secara massal. Sehingga untuk memenuhi permintaan pasar ekspor yang semakin meningkat, maka salah satunya jalan yang dapat ditempuh oleh pengusaha teripang di Sulawesi Selatan adalah melakukan penangkapan di laut lepas dengan cara menyelam menggunakan peralatan canggih ataupun dengan menggunakan alat tangkap jaring trawl mini, walaupun hasil yang diperoleh tidak menentu dan kadangkala tidak seimbang dengan biaya operasional yang dikeluarkan.
HUBUNGAN ANTARA FAKTOR LINGKUNGAN DENGAN PRODUKTIVITAS TAMBAK UNTUK RUMPUT LAUT (Gracilaria verrucosa) DI PANTAI TIMUR PROVINSI SULAWESI SELATAN
Authors: Mustafa Akhmad 
Published: October 2016

Di pantai Timur Provinsi Sulawesi Selatan dijumpai tambak yang lebih luas dibandingkan dengan tambak di pantai Barat dan pantai Selatan. Tambak di pantai timur Sulawesi Selatan umumnya digunakan untuk budidaya rumput laut (Gracilaria verrucosa) dengan kualitas dan kuantitas produksi yang tergolong tinggi. Informasi mengenai hubungan antara faktor lingkungan tambak (kualitas tanah dan kualitas air) dengan produktivitas tambak untuk budidaya rumput laut di pantai Timur Sulawesi Selatan menjadi pokok bahasan dalam tulisan ini. Produktivitas tambak untuk rumput laut di pantai Timur Sulawesi Selatan berkisar antara 150 dan 40.909 dengan rata-rata 7.187 kg kering/ha/tahun. Produktivitas tambak untuk rumput laut yang lebih tinggi di pantai Timur Sulawesi Selatan didapatkan pada tanah dengan pHF lebih besar 6,5; pHFOX lebih besar 4,0; pHF-pHFOX kurang dari 2,5; dan SPOS kurang dari 1,00%. Kandungan Fe tanah yang melebihi 5.000 mg/L dan Al yang melebihi 490 mg/L menyebabkan penurunan produktivitas tambak untuk rumput laut. Peningkatan kandungan PO4 tanah lebih besar dari 6,0 mg/L dapat meningkatkan produktivitas tambak untuk rumput laut secara nyata. Produktivitas tambak untuk rumput laut tertinggi didapatkan pada salinitas 25,6 ppt dan oksigen terlarut 8,39 mg/L dan tumbuh baik pada kisaran pH antara 6,00 dan 9,32; suhu antara 26,00°C dan 37,86°C; fosfat lebih besar 0,1000 mg/L; dan besi kurang dari 0,1000 mg/L di pantai Timur Sulawesi Selatan.
PENYEBAB, DAMPAK, DAN MANAJEMEN PENYAKIT KARANG DI EKOSISTEM TERUMBU KARANG
Authors: Johan Ofri 
Published: October 2016

Penelitian tentang penyakit karang sudah berkembang dan banyak peneliti yang menekuninya di negara asing, namun berbeda dengan di negara Indonesia yang merupakan negara kepulauan dan sebagian besar pulaunya memiliki karang, malah belum ada penelitian dan data tentang penyakit karang, kalaupun ada baru dimulai pada 1 atau 2 lokasi dengan peneliti yang menekuni 1 atau 2 orang saja se-Indonesia. Berbagai faktor lingkungan sebagai penyebab terjadinya penyakit karang di antaranya disebabkan oleh faktor abiotik yaitu oleh stres temperatur, sedimentasi, zat kimia, nutrien tidak seimbang, radiasi ultra-violet, dan faktor biotik seperti predasi, kompetisi dengan alga, dan terinfeksi penyakit. Banyak informasi yang akan dibahas pada tulisan ini sebagai pengantar untuk memahami penyakit karang di antaranya tentang faktor penyebab, jenis, dan dampak penyakit, penelitian di Indonesia, dan manajemen serta pengelolaan yang perlu dilakukan apabila terjadi serangan penyakit di suatu ekosistem terumbu karang.
Commemorating a ‘Foreign’ War in a Neutral Country The Political Insignificance of World War 1 Memory in the Netherlands
Authors: Ribbens Kees 
Published: October 2016

The recent creation of a First World War museum exhibit at Huis Doorn reflects the increased Dutch attention paid to this war, accompanying the international Centenary efforts, although the neutral Netherlands had not been actively involved in the military events of wwi. This initiative, on a small estate where the former German emperor Wilhelm II lived after the defeat of Germany in 1918, was not a natural outcome of the dynamics of Dutch historical culture. This article raises the question of how wwi became increasingly emphasised in the early twenty- first century, and to what extent this reflects a profound change in the national historical culture, which previously displayed no strong connections to wwi. While familiarity with wwi has grown among the Dutch media and the wider public, governmental interest remained limited (very different from the case of wwii), making it rather difficult to actually speak of politics of memory. This article is part of the forum 'Commemorating War 100 years after the First World War'.
Varietas Unggul Tembakau Bondowoso ; Superior Varieties of Bondowoso Tobacco
Authors: Yulaikah Sri , Herwati Anik , Djajadi . 
Published: October 2016

<p>Tembakau di Kabupaten Bondowoso diolah dalam bentuk rajangan dan digunakan sebagai pengisi (filler) dalam blending industri pabrik rokok. Areal penanaman tembakau tiap tahun berkisar antara 7.000–9.000 ha, dengan total produksi per tahun berkisar antara 6.000–8.000 ton. Permasalahan yang ada adalah terbatasnya varietas unggul yang telah dilepas. Eksplorasi telah dilakukan pada tahun 2008, dan m endapatkan 6 aksesi. Uji multilokasi 6 aksesi yaitu Somporis 1, Serumpung, Marakot, Somporis ah, Somporis lokal, dan Somporis ch dilakukan di 2–3 lokasi pada tahun 2009 sampai 2011. Tujuan dari penelitian ini adalah untuk memilih kultivar yang memiliki penampilan terbaik. Hasil pengujian menunjukkan bahwa Somporis 1 dan Somporis ch merupakan kultivar yang unggul berdasarkan indeks penampilan. Produktivitas Somporis 1 se-besar 0,94 ton/ha, indeks mutu 70,73, dan warna kuning tua (cemerlang). Sedang Somporis ch produktivi-tas 0,73 ton/ha, indeks mutu 71,8, dan sangat aromatis. Kedua kultivar tersebut dapat direkomendasikan sebagai varietas yang unggul dan legal di Bondowoso.</p><p> </p><p>Tobacco which was planted in Bondowoso Regency, East Java is processed as air-dried-sliced tobacco and is used as filler in cigarette blending. Tobacco planting area is about 7,000–9,000 ha per year with total pro-duction is about 6,000–8,000 tons. The problem was on Bondowoso tobacco is a shortage availability of superior varieties. The exploration of Bondowoso tobacco was started in 2008 and found six cultivars i.e. Somporis 1, Serumpung, Marakot, Somporis ah, local Somporis, and Somporis ch. Multilocation trials of the six cultivars at 2–3 sites were conducted from 2009–2011. The objective of this research was to select the superior Bondowoso tobacco cultivars. Result showed that Somporis 1 and Somporis ch were the superior varieties based on performance index parameters. Somporis 1 had yield 0.94 tons/ha, quality index 70.73, and dark yellow colour (bright). The yield of Somporis ch were 0.73 tons/ha, it’s quality index 71.8, and very aromatic. These cultivars might be recomended as legalized superior varieties tobacco in Bondowoso.</p>
How Safety Cases and Bowties Can be Used to Improve Safety
Authors: Rowe Richard , O'Toole Peter , Brett Ryan , Alzouebi Ahmed 
Published: October 2016

Abstract
This paper, describes shortcomings of prescriptive regimes and the emergence of and progressive internationalisation of what is variously described as a goal setting or risk-based approach. Specifically the adoption of the "safety case regime" and how it can be used to improve standards of safety and used as a decision support tool is described.
The introduction of a "safety case regime" has taken the industry several years to fully appreciate and effectively apply it as a tool for improving standards of safety. The development of a safety case can provide essential insight into the risks facing an installation and the controls required to manage them. How this information is then used most effectively in operations is still an area for improvement; however there are some key approaches that can provide valuable insight and information to operators on a day to day basis.
Historically, most regulatory safety regimes have prescribed rules and standards that must be achieved, with varying degrees of enforcement. The limitations of this approach have been demonstrated in subsequent major accidents following which it was shown that the law was being complied with. A typical response to such incidents was to amend the regulations; often resulting in unnecessary additional costs, and a detailed focus on compliance, rather than understanding the risks associated with an individual facility and how it is operated. The safety case regime was born out the recognition that such mandated regimes were not effective in preventing major accidents.
The use of Bowties as an operational risk based decision support tool is considered with both the benefits and potential pitfalls of this approach being described. This paper builds on extensive experience gained in the North Sea and an approach being developed for use offshore Ghana.