bluuebunny/crossref_metadata_2025_split huggingface dataset:
DENGUE: UMA ANÁLISE CLIMATO-GEOGRÁFICA NA CIDADE DE JATAÍ-GO
Authors: Cardoso Pereira Clarissa , De Fátima Mariano Zilda , Ricardo Rodrigues Rocha José 
Published: July 2016

Os atuais estudos de geografia da saúde vêm abordando, principalmente, ainfluência do meio geográfico, as alterações ambientais e a organização social,sobre a saúde e qualidade de vida das pessoas. Esses estudos, em sua maioria,visam contribuir com os programas de saúde pública e de planejamentoambiental urbano. Nesse sentido, este presente artigo tem como objetivoanalisar a variabilidade da precipitação pluvial com o número de casos dedengue no município de Jataí-GO, no período de 2007 a 2009. Foram instaladasestações automáticas para mensuração dos elementos climáticos comotemperatura do ar e umidade do ar e pluviômetros para a coleta da precipitaçãopluvial, em vários pontos no perímetro urbano. Esses dados foram tabulados ecorrelacionados com os casos confirmados de dengue. Desta forma, no períodode 2007 a 2009, ocorreu grande variabilidade na distribuição da dengue nosbairros. Os maiores números de casos se concentraram na região do CentroTécnico Sucam, com 181 de ocorrências, de um total de 703 casos registrados,correspondendo a 26%. O bairro Centro e Vila Fátima foram os queapresentaram o maior número de casos, registrando 49 e 89 casos de denguerespectivamente. Em seguida o setor Aeroporto com o registro de 39 casos dedengue. Embora o mês de março fosse o mais chuvoso (acima de 320 mm), osmaiores números casos de dengue ocorreram após o mês de março, nos mesesde abril (109 casos) e maio (107), pois é neste período em que há umadiminuição das chuvas e do escoamento superficial, além acúmulo de água nosrecipientes que favorecem a proliferação de larvas, confirmado por Silva (2006e 2007). A partir dos resultados obtidos, consideramos que o mosquitotransmissor da dengue vem, ao longo do tempo, se adaptando ao meio urbano,pois, é neste ambiente que encontra as condições ambientais e sociais ideaispara a sua procriação. Os maiores índices de casos de dengue em Jataí seguemum padrão sazonal na estação do verão e outono, principalmente nos meses de março, abril e maio com condições ambientais propiciam ao desenvolvimentodos ovos do mosquito Aedes aegypti.
PRECIPITAÇÃO NAS MESORREGIÕES DO ESTADO DO PARÁ: CLIMATOLOGIA, VARIABILIDADE E TENDÊNCIAS NAS ÚLTIMAS DÉCADAS (1978-2008)
Authors: Fernandes de Albuquerque Monik , Barreiros de Souza Everaldo , Do Carmo Felipe de Oliveira Maria , Augusto de Souza Júnior José 
Published: July 2016

Este trabalho utilizou dados de precipitação do período de 1978 a 2008 dobanco de dados do projeto Rede Estadual de Previsão Climática eHidrometeorologica do Pará (RPCH), com o objetivo de estudar a Climatologia,Variabilidade e Tendência da precipitação nas seis mesorregiões do estado doPará, nas últimas décadas, considerando a escala anual, sazonal e mensal paraanalise climatologia e as médias anuais e sazonais para a análise davariabilidade e tendência da precipitação nas diferentes mesorregiões do Pará.Os resultados evidenciaram que, os maiores índices pluviométricos estãoconcentrados nas mesorregiões do Marajó, Metropolitana e Nordeste Paraense,com precipitação anual superior a 2000 mm. Por outro lado, os menores valoresanuais de precipitação, ficam reservados as mesorregiões Sudeste e Sudoestedo Pará. Observou-se claramente que o verão e o outono, seguramente,abrigam os meses mais chuvosos do estado. Em geral, a época chuvosa iniciaseem dezembro e tem duração de cinco a seis meses, sendo o mês de março oque apresenta maior índice pluviométrico. A época menos chuvosa, ondepredominam as chuvas de caráter convectivo, abrangem os demais meses doano, sendo que o período de maior estiagem ocorre entre os meses de setembroe outubro. Observando as séries temporais da anomalia de precipitaçãopadronizada anual, nota-se que a precipitação passou a apresentar anomaliasnegativas a partir da década de 90, para quase todas as mesorregiões do estado, ressaltando que apenas a mesorregião Nordeste do estado, nãoapresenta grande variação de anomalia. A análise individual sazonal pode-senotar uma inversão no padrão anual de anomalia, no trimestre de MAM, comaltos índices de anomalia de precipitação após a década de 90, para todas asmesorregiões do Pará.
ESPAÇOS INVISÍVEIS: ARTE E ARQUITETURA NA CIDADE CONTEMPORÂNEA
Authors: Junqueira ribeiro pinto Julia 
Published: July 2016

Arte e arquitetura partilham questões comuns dentro do campo ampliado da cultura, visando a compreensão do mundo contemporâneo, no qual a cidade genérica, regida por produções imateriais de valor, é expoente. Parte necessária à manutenção deste sistema são os espaços residuais, por exemplo aqueles comumente gerados em renovações urbanas especulativas. É tamanha a dificuldade de se lidar com eles, são espaços ignorados, quase invisíveis. Porém, nesses lugares onde o tecido da cidade afrouxa – a densidade diminui, assim como os fluxos –, ficam evidentes os valores, dinâmicas e fraquezas contemporâneas. Daí a potência de intervenções que chamam a atenção para esses locais. Assim, o presente trabalho analisa e compara práticas recentes no contexto brasileiro de três artistas-arquitetos – Lotes Vagos, de Louise Ganz; Vazadores e Calçada, de Rubens Mano; e Amnésias Topográficas I, Amnésias Topográficas II e Espaços Públicos Invisíveis, de Carlos Teixeira – para entender como eles lidam com a realidade espacial desse mundo capitalizado e fragmentado e ao mesmo tempo dinâmico e virtualizado.
Tegenstrijdig belang bij een vriendelijk openbaar bod
Authors: van den Bosch T.W. , Meijs A.J.C.M. 
Published: July 2016

Tegenstrijdig belang bij een vriendelijk openbaar bod. Een bespreking aan de hand van het openbaar bod op Koninklijke Ten Cate N.V.
In de periode voorafgaand aan het vriendelijk openbaar bod op alle aandelen in de beursgenoteerde vennootschap Koninklijke Ten Cate N.V. is veel commotie ontstaan over de rol van een van haar bestuurders. Deze bestuurder werd onder meer belangenverstrengeling verweten. Aan de hand van deze overname wordt de problematiek omtrent het tegenstrijdig belang besproken, met name ten aanzien van bestuurders van beursgenoteerde vennootschappen. Aan de hand van de wet, Corporate Governance Code en jurisprudentie wordt besproken of de omstandigheden zoals die gedurende dit overnameproces aan de orde waren, kwalificeren als een tegenstrijdig belang.
Vennootschappelijk belang en doeloverschrijding
Authors: Viëtor D.A. , Speyart H.M.H. 
Published: July 2016

Vennootschappelijk belang en doeloverschrijding. Art. 2:7 BW richtlijnconform uitgelegd
Art. 2:7 BW heeft een Unierechtelijke achtergrond. Het is gebaseerd op de Eerste Richtlijn Vennootschapsrecht. Een richtlijnconforme uitleg van art. 2:7 BW brengt mee dat bij rechtshandelingen van een rechtspersoon art. 2:7 BW geen ruimte biedt voor enige derogerende werking van het vennootschappelijk belang en er onder normale omstandigheden evenmin sprake is van een onderzoeksplicht voor de wederpartij van de rechtspersoon naar het doel van die rechtspersoon.
Conducting Sensitive Interviews: A Review of Reflections
Authors: Melville Angela , Hincks Darren 
Published: July 2016

Conducting Sensitive Interviews: A Review of Reflections
Sensitive interviews involve emotionally difficult topics which require participants to face issues that are deeply personal and possibly distressing. This paper draws together reflections concerning how researchers manage the challenges of conducting sensitive interviews, including the author’s own reflections concerning interviewing clinical negligence claimants. First, it examines the ethical guidelines that regulate sensitive research, and the challenges of obtaining informed consent and maintaining confidentiality. Ethical guidelines, however, provide limited assistance for ensuring the emotional care of research participants, and we also consider challenges that are not usually formally regulated. These include preparing for the interview, and then ensuring the emotional care of participants both during and after the interview itself. Sensitive research also raises deeper ethical issues concerning the negotiation of relations between researcher and participant, especially when this relationship is unequal. Finally, while previous research has generally focused on the need to take emotional care of research participants, less attention has been given to the emotional needs of researchers. It is argued that support systems for researchers are too often ad hoc, and that providing support is often not a priority of granting bodies, grant holders or supervisors, and that formal systems need to be put in place.
Validation of the Biofish-300 HIS Enzymatic Biosensor for the Detection of Histamine in Fishery Products
Authors: Salleres Sandra , González Irune , Arantzamendi Alai , González Roberto , Maza Sonia , Jaureguibeitia Arrate , Hungerford James M , DeWitt Christina A , Benner Ronald A 
Published: July 2016

Abstract
The Biofish-300 HIS method is a simple, reliable, and specific enzymatic biosensor for the detection of histamine. This technology is highly specific and selective and allows quantification of histamine in fishery products (fresh/frozen and processed) in a short time frame (2–3 min). Histamine in raw tuna, raw mackerel, raw sardine, raw anchovy, boiled tuna, canned tuna in water, canned tuna in oil, canned mackerel in tomato sauce, canned pickled sardine, and canned salted anchovy was analyzed using a water-based extract. Matrix-specific assay procedures and calibration curves were used to enable analyses to be carried out across multiple sample types. The performance of this assay was examined using samples that were naturally contaminated (reference materials and interlaboratory studies) and spiked with histamine. All data were judged against previously established acceptance criteria. Performance measures were evaluated for linearity, selectivity, matrix, lot consistency, and robustness. Results produced in all performance measures, except robustness, were within acceptable ranges. Out-of-range robustness results reflected deviation in sample volume compared to the standard assay procedures. Positive interferences from the presence of agmatine were shown.
Mesenchymal Stem Cells Modulate the Functional Properties of Microglia via TGF-β Secretion
Authors: Noh Min Young , Lim Su Min , Oh Ki-Wook , Cho Kyung-Ah , Park Jinseok , Kim Kyung-Suk , Lee Su-Jung , Kwon Min-Soo , Kim Seung Hyun 
Published: July 2016

Abstract
The regulation of microglial cell phenotype is a potential therapeutic intervention in neurodegenerative disease. Previously, we reported that transforming growth factor-β (TGF-β) levels in mesenchymal stromal cells (MSCs) could be used as potential biological markers to predict the effectiveness of autologous MSC therapy in patients with amyotrophic lateral sclerosis. However, the underlying mechanism of TGF-β in MSCs was not fully elucidated in determining the functional properties of microglia. In this study, we aimed to clarify the role of TGF-β that is involved in MSC effectiveness, especially focusing on microglia functional properties that play a pivotal role in neuroinflammation. We found that MSC-conditioned media (MSC-CM) inhibited proinflammatory cytokine expression, restored alternative activated microglia phenotype markers (fractalkine receptor, mannose receptor, CD200 receptor), and enhanced phagocytosis in lipopolysaccharide (LPS)-stimulated microglia. In addition, TGF-β in MSC-CM played a major role in these effects by inhibiting the nuclear factor-κB pathway and restoring the TGF-β pathway in LPS-stimulated microglia. Recombinant TGF-β also induced similar effects to MSC-CM in LPS-stimulated microglia. Therefore, we propose that MSCs can modulate the functional properties of microglia via TGF-β secretion, switching them from a classically activated phenotype to an inflammation-resolving phenotype. The latter role may be associated with the inhibition of neuroinflammatory processes in neurodegenerative disorders.

Significance
The results of this study showed that microglia functional properties may be modulated depending on the composition and quantity of mesenchymal stromal cell (MSC)-secreting factors. Transforming growth factor (TGF)-β is proposed as a modulator of microglia functional properties among MSC-secreting factors, and this study aligns with a previous clinical study by these same authors. TGF-β releasing capacity could be an important factor enhancing the therapeutic efficacy of MSCs in clinical trials.
Externally Applied Static Magnetic Field Enhances Cardiac Retention and Functional Benefit of Magnetically Iron-Labeled Adipose-Derived Stem Cells in Infarcted Hearts
Authors: Wang Jian , Xiang Bo , Deng Jixian , Lin Hung-Yu , Zheng Dayang , Freed Darren H. , Arora Rakesh C. , Tian Ganghong 
Published: July 2016

Abstract

Although adipose-derived stem cells (ASCs) hold the promise of effective therapy for myocardial infarction, low cardiac retention of implanted ASCs has hindered their therapeutic efficiency. We investigated whether an externally applied static magnetic field (SMF) enhances cardiac localization of "magnetic" cells and promotes heart function recovery when ASCs are preloaded with superparamagnetic iron oxide (SPIO) nanoparticles. The influence of SMF (0.1 Tesla) on the biological activities of SPIO-labeled ASCs (SPIOASCs) was investigated first. Fifty-six female rats with myocardial infarction underwent intramyocardial injection of cell culture medium (CCM) or male SPIOASCs with or without the subcutaneous implantable magnet (CCM-magnet or SPIOASC-magnet). Four weeks later, endothelial differentiation, angiogenic cytokine secretion, angiogenesis, cardiomyocyte apoptosis, cell retention, and cardiac performance were examined. The 0.1-Tsela SMF did not adversely affect the viability, proliferation, angiogenic cytokine secretion, and DNA integrity of SPIOASCs. The implanted SPIOASCs could differentiate into endothelial cell, incorporate into newly formed vessels, and secrete multiple angiogenic cytokines. Four weeks after cell transplantation, the number of cardiac SPIOASCs was significantly increased, vascular density was markedly enlarged, fewer apoptotic cardiomyocytes were present, and heart contractile function was substantially improved in the SPIOASC-magnet treated rats in comparison with the SPIOASC-treated rats. The SPIOASCs could differentiate into endothelial cells, incorporate into vessels, promote angiogenesis, and inhibit ischemic cardiomyocyte apoptosis. An externally applied SMF offered a secure environment for biological properties of SPIOASCs, increased the cardiac retention of implanted magnetic SPIOASCs, and further enhanced heart function recovery after myocardial infarction.

Significance
This pilot proof-of-concept study suggests that a 0.1-Tesla static magnetic field does not adversely affect the viability, proliferation, angiogenic cytokine secretion, or DNA integrity of the superparamagnetic iron oxide-labeled adipose-derived stem cells (SPIOASCs). Implantation of adipose-derived stem cells promotes myocardial neovascularization and inhibits ischemic cardiomyocyte apoptosis through endothelial differentiation, incorporation into vessels, and paracrine factor secretion. An externally applied static magnetic field enhanced myocardial retention of intramyocardially injected "magnetic" SPIOASCs and promoted cardiac function recovery after myocardial infarction. With further preclinical optimization, this approach may improve the outcome of current stem cell therapy for ischemic myocardial infarction.
In Pursuit of Authenticity: Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Clinical Applications
Authors: Miyagishima Kiyoharu J. , Wan Qin , Corneo Barbara , Sharma Ruchi , Lotfi Mostafa R. , Boles Nathan C. , Hua Fang , Maminishkis Arvydas , Zhang Congxiao , Blenkinsop Timothy , Khristov Vladimir , Jha Balendu S. , Memon Omar S. , D’Souza Sunita , Temple Sally , Miller Sheldon S. , Bharti Kapil 
Published: July 2016

Abstract
Induced pluripotent stem cells (iPSCs) can be efficiently differentiated into retinal pigment epithelium (RPE), offering the possibility of autologous cell replacement therapy for retinal degeneration stemming from RPE loss. The generation and maintenance of epithelial apical-basolateral polarity is fundamental for iPSC-derived RPE (iPSC-RPE) to recapitulate native RPE structure and function. Presently, no criteria have been established to determine clonal or donor based heterogeneity in the polarization and maturation state of iPSC-RPE. We provide an unbiased structural, molecular, and physiological evaluation of 15 iPSC-RPE that have been derived from distinct tissues from several different donors. We assessed the intact RPE monolayer in terms of an ATP-dependent signaling pathway that drives critical aspects of RPE function, including calcium and electrophysiological responses, as well as steady-state fluid transport. These responses have key in vivo counterparts that together help determine the homeostasis of the distal retina. We characterized the donor and clonal variation and found that iPSC-RPE function was more significantly affected by the genetic differences between different donors than the epigenetic differences associated with different starting tissues. This study provides a reference dataset to authenticate genetically diverse iPSC-RPE derived for clinical applications.

Significance
The retinal pigment epithelium (RPE) is essential for maintaining visual function. RPE derived from human induced pluripotent stem cells (iPSC-RPE) offer a promising cell-based transplantation therapy for slowing or rescuing RPE-induced visual function loss. For effective treatment, iPSC-RPE must recapitulate the physiology of native human RPE. A set of physiologically relevant functional assays are provided that assess the polarized functional activity and maturation state of the intact RPE monolayer. The present data show that donor-to-donor variability exceeds the tissue-to-tissue variability for a given donor and provides, for the first time, criteria necessary to identify iPSC-RPE most suitable for clinical application.
How smartphone usage correlates with social anxiety and loneliness
Authors: Gao Yusong , Li Ang , Zhu Tingshao , Liu Xiaoqian , Liu Xingyun 
Published: July 2016

Introduction:Early detection of social anxiety and loneliness might be useful to prevent substantial impairment in personal relationships. Understanding the way people use smartphones can be beneficial for implementing an early detection of social anxiety and loneliness. This paper examines different types of smartphone usage and their relationships with people with different individual levels of social anxiety or loneliness.Methods:A total of 127 Android smartphone volunteers participated in this study, all of which have agreed to install an application (MobileSens) on their smartphones, which can record user’s smartphone usage behaviors and upload the data into the server. They were instructed to complete an online survey, including the Interaction Anxiousness Scale (IAS) and the University of California Los Angeles Loneliness Scale (UCLA-LS). We then separated participants into three groups (high, middle and low) based on their scores of IAS and UCLA-LS, respectively. Finally, we acquired digital records of smartphone usage from MobileSens and examined the differences in 105 types of smartphone usage behaviors between high-score and low-score group of IAS/UCLA-LS.Results:Individuals with different scores on social anxiety or loneliness might use smartphones in different ways. For social anxiety, compared with users in low-score group, users in high-score group had less number of phone calls (incoming and outgoing) (Mann-Whitney U= 282.50∼409.00,p< 0.05), sent and received less number of text messages in the afternoon (Mann-Whitney U= 391.50∼411.50,p< 0.05), used health & fitness apps more frequently (Mann-Whitney U= 493.00,p< 0.05) and used camera apps less frequently (Mann-Whitney U= 472.00,p< 0.05). For loneliness, users in low-score group, users in high-score group had less number of phone calls (incoming and outgoing) (Mann-Whitney U= 305.00∼407.50,p< 0.05) and used following apps more frequently: health & fitness (Mann-Whitney U= 510.00,p< 0.05), system (Mann-Whitney U= 314.00,p< 0.01), phone beautify (Mann-Whitney U= 385.00,p< 0.05), web browser (Mann-Whitney U= 416.00,p< 0.05) and social media (RenRen) (Mann-Whitney >U= 388.50,p< 0.01).Discussion:The results show that individuals with social anxiety or loneliness receive less incoming calls and use healthy applications more frequently, but they do not show differences in outgoing-call-related features. Individuals with higher levels of social anxiety also receive less SMSs and use camera apps less frequently, while lonely individuals tend to use system, beautify, browser and social media (RenRen) apps more frequently.Conclusion:This paper finds that there exists certain correlation among smartphone usage and social anxiety and loneliness. The result may be useful to improve social interaction for those who lack social interaction in daily lives and may be insightful for recognizing individual levels of social anxiety and loneliness through smartphone usage behaviors.
Shades of yellow: interactive effects of visual and odour cues in a pest beetle
Authors: Arnold Sarah E.J. , Stevenson Philip C. , Belmain Steven R. 
Published: July 2016

Background:The visual ecology of pest insects is poorly studied compared to the role of odour cues in determining their behaviour. Furthermore, the combined effects of both odour and vision on insect orientation are frequently ignored, but could impact behavioural responses.Methods:A locomotion compensator was used to evaluate use of different visual stimuli by a major coleopteran pest of stored grains (Sitophilus zeamais), with and without the presence of host odours (known to be attractive to this species), in an open-loop setup.Results:Some visual stimuli—in particular, one shade of yellow, solid black and high-contrast black-against-white stimuli—elicited positive orientation behaviour from the beetles in the absence of odour stimuli. When host odours were also present, at 90° to the source of the visual stimulus, the beetles presented with yellow and vertical black-on-white grating patterns changed their walking course and typically adopted a path intermediate between the two stimuli. The beetles presented with a solid black-on-white target continued to orient more strongly towards the visual than the odour stimulus.Discussion:Visual stimuli can strongly influence orientation behaviour, even in species where use of visual cues is sometimes assumed to be unimportant, while the outcomes from exposure to multimodal stimuli are unpredictable and need to be determined under differing conditions. The importance of the two modalities of stimulus (visual and olfactory) in food location is likely to depend upon relative stimulus intensity and motivational state of the insect.