bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Shared Genetic Features and Molecular Mechanisms between Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma through
Bioinformatics
Authors: Tian ChengLong , Li Zheng , Liu QinLong 
Published: October 2024

Background:
Hepatocellular Carcinoma (HCC) is one of the most common
malignant tumors in the world, characterized by high incidence, high malignancy, and low
survival rate. Currently, 1/4 of adults in the world suffer from Non-Alcoholic Fatty Liver
Disease (NAFLD), with an incidence rate of 27% in Asia.

Methods:
We used TCGA and GEO public database data sets to conduct weighted gene coexpression
network analysis to identify relevant gene modules, defined the intersection of
tumorigenesis-related modules and NASH development-related modules as shared genes, and
then used single-factor Cox, LASSO, and multivariate Cox regression analysis screened out core
shared genes and verified their prognostic value. We further investigated the relationship
between core shared genes and immune infiltration, tumor mutational load, and drug sensitivity.
Finally, RT-qPCR was used to verify its mRNA expression in different cell lines.

Results:
We identified Karyopherin α 2 (KPNA2) as the core shared gene between NASH and
HCC. Patients were divided into low-risk groups and high-risk groups based on the expression
of KPNA2. The prognosis of the low-risk group was significantly better than that of the highrisk
group. Furthermore, we found significant differences in tumor immune cell infiltration,
somatic mutations, microsatellite instability, and drug sensitivity between different expression
groups.

Conclusion:
There are very few studies on the molecular mechanism of the relationship between
NAFLD and HCC. Our study demonstrates that KPNA2 is a potential therapeutic target and
immune-related biomarker for patients with NAFLD and HCC.
Microwave-assisted Synthesis of Benzimidazole Derivatives: A Green and Effective Approach
Authors: Shah Drashti , Patel Maitri , Patel Dharti , Patel Ashish 
Published: October 2024

Background:
Benzimidazole derivatives are pivotal in medicinal chemistry due to their
diverse therapeutic applications. Traditional synthesis methods often require catalysts and long reaction
times, which can be inefficient and environmentally unfriendly. Hence, there is a growing need
for more efficient and eco-friendly synthetic methodologies.

Methods:
A newly devised and efficacious synthetic methodology has been established for the synthesis
of benzimidazole derivatives, employing microwave assistance without the requirement for a
catalyst. This method facilitated the synthesis of fifteen derivatives with notable efficiency, characterized
by significantly reduced reaction times ranging from 5 to 10 minutes and impressive yields
ranging from 94% to 98%.

Results:
The identity and purity of the synthesized benzimidazole derivatives were meticulously
verified through a comprehensive analysis, encompassing a comparison of their physicochemical
properties and spectral characteristics with authenticated reference data.

Conclusion:
This method represents a significant advancement in the synthesis of benzimidazole
derivatives, offering a rapid and high-yielding alternative to traditional synthetic routes.
SEGO BORANAN IN BUYING AND SELLING CONTEXT OF MATHEMATICS PROBLEM SOLVING
Authors: Ardiansyah Adi Satrio , Fitriana Dea Rizqi , Chafshoh Nabillah Arifa , Isbianto Isbianto , Ali Mat , Susnasuhah Lilik 
Published: October 2024

This study aims to develop problem based learning in ethnomathematics-based textbooks through Sego Boranan’s buying and selling activities to improve students' problem-solving abilities in social arithmetic material. Research development were carried out a procedure of 3D (Define, Design, Develop). The feasibility assessment was carried out by experts and practitioners using the feasibility sheet, the readability assessment by students who had obtained Social Arithmetic material using readability sheets, and student responses by students who were studying Social Arithmetic material using a student response questionnaire. The textbooks developed were included in the very feasible criteria, was easy to understand, and very feasible to be implemented in learning mathematics. Although it is suggested that using an experimental method can test the effectiveness of using this textbook on learning outcomes and students' problem-solving abilities, this paper presented examples of ethnomathematics problem solving that can be practically implemented in mathematics classrooms.
Tobacco and Alcohol Content in Top Vietnamese YouTube Music Videos: Content Analysis
Authors: Tran Thi Phuong Thao , Vu Thu Trang , Li Yachao , Popova Lucy 
Published: October 2024

Background
Seeing portrayals of tobacco and alcohol in music videos (MVs) may reduce perceived risks, increase susceptibility, and lead to the initiation of tobacco and alcohol use among adolescents and young adults. Previous studies have predominantly concentrated on assessing tobacco and alcohol contents in English-language MVs within Western countries. However, many other countries have not only been influenced by the English music market but have also produced music in their native languages, and this content remains underexamined.

Objective
This study aims to investigate the prevalence of tobacco- and alcohol-related content in top Vietnamese MVs on YouTube from 2013 to 2021, to describe how tobacco and alcohol are portrayed in these MVs, and to examine associations between these portrayals and MV characteristics.

Methods
A total of 410 Vietnamese MVs, including the top 40 or 50 most viewed released each year between 2013 and 2021, were analyzed. General information, such as the song name, its release date and ranking, age restriction, musical genre, and type of MV, was collected. We examined tobacco and alcohol content in the MVs, with specific details such as tobacco types, their brands, as well as the number, age, sex, and roles of individuals smoking or drinking.

Results
Among the 410 MVs, 36 (8.8%) contained tobacco-related content and 136 (33.2%) featured alcohol-related content. Additionally, 28 (6.8%) out of 410 MVs included both tobacco and alcohol content. The prevalence of videos with tobacco and alcohol content fluctuated over the years. In MVs with tobacco-related content, a higher proportion of hip-hop or rap songs contained tobacco-related content (n=6, 30%) compared to other music genres. In MVs with tobacco-related content, cigarettes were the most frequently shown product (n=28, 77.8%), and smoking scenes were often depicted at parties (n=13, 36.1%) and during dancing and singing scenes (n=12, 33.3%). Among the 31 MVs portraying actual tobacco use, tobacco use was typically depicted with 1 person, often a young adult male, while 38.7% (n=12) showed singer(s) smoking. For MVs with alcohol-related content, there was a high proportion showing alcohol images at parties, bars, or pubs (n=96, 70.6%). Among 87 MVs containing drinking scenes, 60.9% (n=53) involved groups of young adults of both sexes, and 64% (n=56) depicted singers drinking. Additionally, only 2 (5.6%) MVs included health warnings about tobacco harm, and 2 MVs (1.5%) included warnings about drinking restricted to individuals 18 years and above.

Conclusions
The notable prevalence of tobacco and alcohol content in leading Vietnamese YouTube MVs raises concerns, especially as most of this content is portrayed without any warnings. The study underscores a regulatory gap in addressing such content on the internet, emphasizing the urgent need for stricter regulations and age restrictions on platforms such as YouTube.
Social Contexts in Social Work: a View from Teachers in the Centro East and Colombian Caribbean Region
Authors: Salcedo Carmen Cadrazco , Franco Xilena Gil , Baraahona Ana Yadira , Teheran Kelly Diaz , Carazo Rosana Martinez , Contreras Blanca Perez 
Published: October 2024

Objective: To reveal, from the point of view of the teachers dedicated to the training of social workers, the meanings they attribute to the social contexts in order to establish relationships with the training emphases proposed by the social work programs in the Caribbean and central-eastern regions of the Colombian territory.

Theoretical Framework: oriented from the study group methodology, where the exchange of knowledge was the basis for analyzing and deciding the basic theoretical course for the configuration of historical and theoretical perspectives of the developed process, based on local sociologies to understand life contexts of subjects and communities, which paraphrasing Wiebke Keim (2010) work the dynamics of the local, recovering the voices of actors against the classical social theory that marked even the powers of the so-called North Atlantic.

Method: the study was developed from the hermeneutic paradigm, qualitative approach, non-probabilistic designs, focus group technique and discourse analysis, aimed at teachers of Social Work Programs.

Results and Discussion: the relationship of the context as a scenario where interactions are developed is reaffirmed, product of an economic structure that determines certain social representations, built in the groups permeated by social dynamics and intervention processes influenced by diagnoses that give reading to social, economic and political determinants that allow their development.

Research Implications: It contributes to the epistemological, theoretical and methodological developments of Social Work from the reading of context.

Originality/value: It provides views of context related to the emphasis of training that give sense to areas of professional performance.
Analisis Risiko Sanitasi dan Kejadian Penyakit Kulit di Kecamatan Medan Belawan Kota Medan
Authors: Malau Pitto , Naria Evi , Indirawati Sri Malem 
Published: October 2024

Pendahuluan : Penyakit kulit merupakan salah satu penyakit yang paling sering ditemukan di negara beriklim tropis. Merujuk pada data BPS tahun 2019 penyakit kulit masuk dalam 10 deretan penyakit terbesar di Kota Medan. Berdasarkan data penyakit yang diperoleh dari Puskesmas Medan Belawan penyakit kulit masuk dalam 10 deretan penyakit tertinggi pada tahun 2022-2023 yaitu sebanyak 1751 kasus dengan persentase sebesar 24 persen. Berdasarkan data dan hasil observasi yang dilakukan masih banyak rumah tangga yang belum memiliki akses sanitasi dasar yang lengkap dan memenuhi standar kesehatan salah satunya adalah saluran pembuangan air limbah (SPAL). Mayoritas SPAL rumah tangga terbuka dan mencemari lingkungan. Tujuan Penelitian : Penelitian ini bertujuan untuk menganalisis risiko sanitasi variabel saluran pembuangan air limbah dengan kejadian penyakit kulit. Metode : Penelitian ini merupakan penelitian kuantitatif dilaksanakan di bulan Desember 2023 sampai Juni 2024. Populasi terdiri dari 27.114 rumah tangga dengan sampel sebanyak 100 rumah tangga. Pengambilan sampel dalam penelitian ini menggunakan purposive sampling. Data dikumpulkan melalui wawancara menggunakan instrument kuesioner kemudian akan dihitung menggunakan rumus perhitungan Indeks risiko sanitasi (IRS) sehingga akan diperoleh skor yang menyatakan risiko sanitasi. Untuk melihat hubungan variabel saluran pembuangan air limbah (SPAL) dengan kejadian penyakit kulit maka digunakan analisis statistik chi square. Simpulan : Berdasarkan hasil penelitian maka diperoleh indeks risiko sanitasi untuk variabel saluran pembuangan ari limbah (SPAL) rumah tangga berada pada kategori risiko sanitasi sangat tinggi. Hasil analisis statistic menunjukkan bahwa terdapat hubungan antara saluran pembuangan air limbah dengan kejadian penyakit kulit dengan perolehan nilai p value = 0.028 dan nilai Exp-B sebesar 4.01. Berdasarkan hasil penelitian yang dilakukan indeks risiko sanitasi saluran pembuangan air limbah berada pada kategori risiko sangat tinggi dengan indeks skor sebesar 67. Berdasarkan analisis statistik diperoleh hubungan antara saluran pembuangan air limbah dengan kejadian penyakit kulit (p value 0.028, PR= 1.7). Pengelolaan SPAL rumah tangga perlu ditingkatkan yaitu dengan jenis SPAL tertutup/memenuhi syarat kesehatan yang tidak menimbulkan pencemaran lingkungan.
METHOD OF DETERMINING THE ENERGY RELATIONSHIP BETWEEN PRODUCTS TEMPERATURNOI DESTRUCTION OF ITS SYNTHETIC OILS
Authors: Ковальский Б.И. , Рунда М.М. , Васильев А.В. , Акимов М.В. , Анакин М.Ф. 
Published: October 2024

В статье ппредставлены результаты испытания синтетических моторных масел на температурную стойкость в температурном интервале от 140 до 300 оС с учетом тепловой энергии, поглощенной продуктами температурной деструкции и испарения. Установлены линейные зависимости между десятичными логарифмами тепловой энергии, поглощенной продуктами температурной деструкции и испарения. Показано, что процессы температурной деструкции начинаются после испарения определенной массы, т.е. при термостатировании в первую очередь происходят процессы испарения, а после поглощения маслом определенного количества тепловой энергии происходит обоюдное увеличение концентрации продуктов деструкции и испарения
The article presents the results of testing synthetic motor oils for temperature resistance in the temperature range from 140 to 300 oC, taking into account the thermal energy absorbed by the products of thermal degradation and evaporation. Linear relationships between the decimal logarithms of the heat energy absorbed by the products of thermal degradation and evaporation are established. It is shown that the processes of thermal degradation begin after the evaporation of a certain mass, i.e., during temperature control, evaporation processes occur first, and after the absorption of a certain amount of thermal energy by the oil, the concentration of degradation and evaporation products increases mutually.
THERMAL AND DETONATION PROPERTIES OF BICYCLIC NITROTRIAZOLE DERIVATIVES
Authors: Комарова М.В. , Козырев Н.В. , Вакутин А.Г. , Суханова A.Г. 
Published: October 2024

В статье приводятся расчёты детонационных характеристик бициклических производных 3-нитро-1,2,4-триазола и взрывчатых композиций на их основе. Описаны термические свойства бициклических производных и эвтектических сплавов с тротилом, полученные методами термического анализа; указаны температуры плавления эвтектик. Результаты исследования показали, что скорость детонации композитов на основе бициклических производных сопоставима, либо может превышать аналогичный показатель для композиций на основе тротила. Составы, содержащие эвтектические сплавы имеют приемлемые технологические и детонационные свойства. Наиболее перспективными являются Бис[2-(3-нитро-1,2,4-триазол-1-ил)этил]овый эфир и 1,2-Бис(2-(3-нитро-1Н-1,2,4-триазол-1-ил)этокси)этан.
The article presents calculations of detonation characteristics of bicyclic derivatives of 3-nitro-1,2,4-triazole and explosive compositions based on them. The thermal properties of bicyclic derivatives and eutectic melt-casts with TNT obtained by thermal analysis are described; the melting temperatures of eutectic materials are determined. The results of the study showed that the detonation velocity of composites based on bicyclic derivatives the detonation velocity is equal to or higher than for similar compositions with trotyl. Compositions containing eutectic melt-casts have agreeable technological and detonation properties. The most promising are Bis[2-(3-nitro-1,2,4-triazol-1-yl)ethyl]ether and 1,2-Bis(2-(3-nitro-1H-1,2,4-triazol-1-yl)ethoxy)ethane.
PISTON RADIATOR FOR GAS MEDIA
Authors: Хмелев В.Н. , Шалунов А.В. , Нестеров В.А. , Нестеров А.А. , Тертишников П.П. 
Published: October 2024

В статье рассказывается про разработку и создание нового излучателя в форме поршня, который предназначен для озвучивания различных газовых сред. Базой для создания данного излучателя послужило тело в форме цилиндра, длина которой составляет половину длины волны. Данное тело соединялось с электроакустическим преобразователем. Благодаря тому, что присоединительная плоскость, которая предназначается для того, чтобы возбуждать колебания, выполняется углубленной, по отношению к торцевой поверхности, удалось значительно увеличить амплитуду механических колебаний излучающей поверхности. В конце проведения всех необходимых исследований и разработок был создан новый ультразвуковой излучатель. Предложенная конструкция позволяет обеспечивать акустическое воздействие на газодисперсные среды с интенсивностью ультразвукового поля не менее, чем 145 дБ, при уровне потребляемой мощности не превышающей значение 90 Вт.
The article describes the development and creation of a new radiator in the form of a piston, which is designed for voicing various gas environments. The basis for creating this emitter was a body in the form of a cylinder, the length of which is half the wavelength. This body was connected to an electroacoustic Converter. Due to the fact that the connecting plane, which is intended to excite vibrations, is deepened in relation to the end surface, it was possible to significantly increase the amplitude of mechanical vibrations of the radiating surface. At the end of all the necessary research and development, a new ultrasonic emitter was created. The proposed design makes it possible to provide an acoustic effect on gas-dispersed media with an ultrasonic field intensity of at least 145 dB, with a power consumption level not exceeding 90 watts.
SYNTHESIS OF COMPLEX CATIONIC SALTS BASED ON N,N'-DINITROUREA
Authors: Ильясов Д.С. , Ильясов С.Г. 
Published: October 2024

Федеральное государственное бюджетное учреждение науки Институт проблем химико-энергетических технологий Сибирского отделения Российской академии наук, г.Бийск Исследовано взаимодействие дикалиевой соли N,N'-динитромочевины с хлоридами меди, кобальта, никеля в присутствии диаминомочевины. Показано, что происходит образование комплексного катиона меди, кобальта, никеля (2+) с двумя нейтральными молекулами диаминомочевины во внутренней сфере и кислотным остатком анионом N,N'-динитромочевины во внешней сфере. Синтезированные соли идентифицированы ИК- и УФ-спектроскопией.
The reaction between the potassium salt of N,N'-dinitrourea and the chlorides of copper, cobalt and nickel over diaminourea was examined. A complex cation between copper, cobalt, nickel (2+) and two neutral diaminourea molecules within the inner sphere and anionic N,N'-dinitrourea as an acidic residue within the outer sphere was shown to be formed. The synthesized salts were resolved by IR and UV spectroscopies.
Study combustion performance nanothermite composition MoO3/Al/1Ме-3н on the prescription factors
Authors: Гордеев В.В. , Казутин М.В. , Козырев Н.В. 
Published: October 2024

В работе показано влияние содержания 1-метил-3-нитро-1,2,4-триазола (1Ме-3Н) на силу взрыва нанотермитной композиции MoO3/Al/1Ме-3Н. Использовали два способа компоновки рецептур: I – соотношение компонентов соответствовало максимальному расчетному значению теплоты горения (Q) композиции; II – компоновка, в которой соотношение компонентов базовой нанотермитной пары MoO3/Al сохранялось постоянным. Выявлено, что при любом способе рецептурной компоновки зависимость силы взрыва от содержания 1Ме-3Н носит экстремальный характер. При построении рецептуры по I способу максимальная сила взрыва достигается при содержании 1Ме-3Н - 15 % и составляет ~210 % от уровня базовой нанотермитной смеси. При использовании II способа максимальная сила взрыва составляет ~330 % от базового уровня и соответствует содержанию 1Ме-3Н - 30 %.
In this paper, discusses the effect of the additive content 1-methyl-3-nitro-1,2,4-triazole (1Me-3N) on the explosion force of the composition MoO3/Al/1Ме-3Н. Two methods of recipe configuration selected: I - mixing ratio corresponds to the maximum calculated value of combustion heat (Q) of the composition; II - ratio of components nanotermitnoy base pairs MoO3 / Al was kept constant. For each recipe configuration, the dependence of the explosive force on the 1Me-3H content is extreme nature.A recipe configuration to method I the maximum explosive force is achieved when the content 1Me-3H 15% and is about 210% of the base level nanotermite. When using method II, the maximum explosion force is ~ 330% of the baseline level and corresponds to a 1Me-3H content of 30%.
Comparative analysis of measurement techniques of the reactive power of sinusoidal signal
Authors: Серов А.Н. , Серов Н.А. , Долгачева Е.А. 
Published: October 2024

В настоящее время среди параметров реактивной мощности наибольший интерес представляет реактивная мощность основной спектральной компоненты. Сигналы напряжения и тока современных электрических сетей не являются синусоидальными. Однако, для измерения параметров реактивной мощности основной спектральной компоненты могут быть использованы методы анализа синусоидальных сигналов тока и напряжения. Среди известных методов измерения реактивной мощности синусоидального сигнала можно выделить: метод временной задержки, метод предварительного интегрирования, метод предварительного дифференцирования, и метод интегрирования-дифференцирования. Основной причиной возникновения погрешностей рассмотренных методов является наличие гармоник в спектре входного сигнала и отклонение частоты входного сигнала от номинального значения. В настоящей работе выполнен анализ влияния указанных параметров на погрешность измерения реактивной мощности основной спектральной компоненты указанных выше методов измерения. Получены аналитические соотношения, позволяющие оценить погрешность измерения реактивной мощности при отклонении частоты входного сигнала от номинального значения. Предложено звено задержки на целое число тактов для реализации метода временной задержки. Для метода предварительного интегрирования рассмотрена реализация на базе цифрового интегратора первого порядка. Для метода предварительного дифференцирования рассмотрена реализация на основе цифрового дифференциатора первого порядка. Выполнено имитационное математическое моделирование в программных пакетах Mathcad, Matlab и Simulink, подтверждающее справедливость полученных аналитических выражений. Выполнено сравнение рассмотренных методов с точки зрения сложности реализации и погрешности измерения реактивной мощности. Показано, что среди рассмотренных методов измерения наименьшей погрешностью обладает метод интегрирования-дифференцирования.
Abstract – Currently, for reactive power, the greatest interest of reactive power parameters is the reactive power of fundamental spectral component. Voltage and current of the modern electrical networks are not sinusoidal. However, for the measurement of reactive power of fundamental spectral component can be used techniques of analysis of sinusoidal voltage and current. Among known methods of measuring reactive power can be identified, the time-shift technique, preliminary integration technique, preliminary differentiation technique, integration-differentiation technique. The main reason for the occurrence of errors of the considered techniques is the presence of harmonics and frequency deviation of the signal from the nominal value. At the present work the analysis of the impact of these parameters on measurement error of reactive power of the fundamental spectral component. The obtained analytical correlations, allowing to estimate measurement error. Performed analytical modeling in software packages such as Mathcad, Matlab and Simulink, confirming the validity of the obtained analytical expressions.