bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of All-Inside Arthroscopic and Open Techniques for the Modified Broström Procedure for Ankle Instability
Authors: Yeo Eui Dong , Lee Kyung-Tai , Sung Il-hoon , Lee Sun Geun , Lee Young Koo 
Published: September 2016

Background: No reported study has compared clinical and radiologic outcomes between an all-inside arthroscopic modified Broström operation (MBO) and an open MBO. The purpose of this study was to compare clinical and radiologic outcomes of all-inside arthroscopic and open MBOs. Methods: From August 2012 to July 2014, 48 patients were included. They were divided into 2 groups: all-inside arthroscopic MBO (25 patients) and open MBO (23 patients). The American Orthopaedic Foot & Ankle Society (AOFAS) ankle–hindfoot score, visual analog scale (VAS) score, and Karlsson score were used to evaluate clinical outcomes. Anterior talar translation and talar tilt were used to evaluate radiologic outcomes. All patients had lateral ankle instability. MBO was performed in 87 patients. Of these, 50 patients met the inclusion criteria. All patients had giving way, persistent pain, and an inability to resume their preinjury activity level for more than 6 months. Patients were randomized into 2 groups, all-inside arthroscopic MBO and open MBO, using a permuted block randomization method. Clinical outcome evaluations were performed preoperatively, at 6 weeks and 6 months postoperatively, and at a final follow-up at a minimum of 12 months postoperatively using the Karlsson score, the AOFAS ankle-hindfoot score, and pain VAS scores. Radiologic outcome evaluations were performed preoperatively and at 1 year postoperatively at final follow-up using anterior talar translation, and talar tilt angle. Results: After randomization, 25 ankles were allocated to the all-inside arthroscopic MBO group and 25 to the open MBO group. Two ankles in the open MBO group were excluded from the analysis because they were lost to follow-up. Thus, evaluations were performed for 25 ankles in the all-inside arthroscopic MBO group and 23 in the open MBO group. There was no difference in age, gender, symptom duration, preoperative AOFAS, VAS, Karlsson scores, anterior talar translation, or talar tilt between the 2 groups (all P > .05). At the final follow-up, the AOFAS, VAS, and the Karlsson scores had improved significantly in both groups ( P < .001). There was no difference in the Karlsson, AOFAS, or VAS scores, anterior talar translation, or talar tilt between the 2 groups at final follow-up (all P > .05). Conclusions: There was no difference in the clinical or radiologic outcome between the all-inside arthroscopic MBO and open MBO for the treatment of lateral ankle instability at up to 1 year after surgery. An all-inside arthroscopic MBO should be considered carefully in patients who have lateral ankle instability. Level of Evidence: Level I, randomized controlled trial.
Ultrasonographic, endoscopic and histological appearances of the caecum in cats presenting with chronic clinical signs of caecocolic disease
Authors: Hahn Harriet , Pey Pascaline , Baril Aurélie , Charpentier Julie , Desquilbet Loic , Le Poder Sophie , Château-Joubert Sophie , Laloy Eve , Freiche Valerie 
Published: September 2016

Objectives This study aimed to describe the ultrasonographic, endoscopic and histological characteristics of the caecum and ileocaecocolic junction in cats suffering from chronic clinical signs compatible with caecocolic disease. Methods Cats presenting with clinical signs suggestive of a caecocolic disease were prospectively recruited. All cats underwent an ultrasonographic examination of the caecum, ileum, colon, ileocolic lymph nodes and local mesenteric fat, in addition to comprehensive abdominal ultrasonography. This was followed by a colonoscopy with a macroscopic assessment of the caecocolic mucosa; caecocolic tissue samples were systematically collected for histologic analysis. Results Eighteen cats were included. Eleven of 18 cats had ultrasonographic abnormalities adjacent to the ileocaecocolic junction (lymphadenopathy, local steatitis) and 13/18 cats had abnormalities directly related to the junction (wall thickening, loss of wall layering). Seventeen of 18 cats had at least one ultrasonographic abnormality. Endoscopically, hyperaemia, oedema, discoloration and/or erosions were found in all cats. Each cat was classified as having mild or moderate-to-severe lesions according to endoscopic results; no classification could be established statistically for ultrasonographic results. The accentuation of the dimpled pattern tended to be inversely related to the severity of endoscopic lesion scoring. Histologically, a large proportion of cats showed typhlitis (13/16), one had lymphoma and two were normal. All cats with typhlitis also had colitis. There was only slight agreement between endoscopic and histological caecal results regarding the severity of lesions. Loss of caecal wall layering on ultrasound was found in 7/18 cats and, surprisingly, did not appear as a reliable predictor of the severity of inflammation or of malignancy; neither did local steatitis nor lymph node size. Conclusions and relevance Ultrasonography and endoscopy should not be used as the sole methods to investigate the ileocaecocolic region in cats with clinical signs suggestive of caecocolic disease. The presence of chronic clinical signs should routinely prompt histological biopsy.
Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker
Authors: Órpez-Zafra Teresa , Pavía Jose , Hurtado-Guerrero Isaac , Pinto-Medel Maria J , Rodriguez Bada Jose Luis , Urbaneja Patricia , Suardíaz Margarita , Villar Luisa M , Comabella Manuel , Montalban Xavier , Alvarez-Cermeño Jose C , Leyva Laura , Fernández Óscar , Oliver-Martos Begoña 
Published: September 2016

Background: The soluble isoform of the interferon-β (IFN-β) receptor (sIFNAR2) could modulate the activity of both endogenous and systemically administered IFN-β. Previously, we described lower serum sIFNAR2 levels in untreated multiple sclerosis (MS) than in healthy controls (HCs). Objective: To assess sIFNAR2 levels in a new cohort of MS patients and HCs, as well as in patients with clinically isolated syndrome (CIS) and with other inflammatory neurological disorders (OIND) and to assess its ability as a diagnostic biomarker. Methods: The cross-sectional study included 148 MS (84 treatment naive and 64 treated), 87 CIS, 42 OIND, and 96 HCs. Longitudinal study included 94 MS pretreatment and after 1 year of therapy with IFN-β, glatiramer acetate (GA), or natalizumab. sIFNAR2 serum levels were measured by a quantitative ELISA developed and validated in our laboratory. Results: Naive MS and CIS patients showed significantly lower sIFNAR2 levels than HCs and OIND patients. The sensitivity and specificity to discriminate between MS and OIND, for a sIFNAR2 cutoff value of 122.02 ng/mL, were 70.1%, and 79.4%, respectively. sIFNAR2 increased significantly in IFN-β-treated patients during the first year of therapy in contrast to GA- and natalizumab-treated patients who showed non-significant changes. Conclusion: The results suggest that sIFNAR2 could be a potential diagnostic biomarker for MS.
A randomized study of multimedia informational aids for research on medical practices: Implications for informed consent
Authors: Kraft Stephanie A , Constantine Melissa , Magnus David , Porter Kathryn M , Lee Sandra Soo-Jin , Green Michael , Kass Nancy E , Wilfond Benjamin S , Cho Mildred K 
Published: September 2016

Background/Aims: Participant understanding is a key element of informed consent for enrollment in research. However, participants often do not understand the nature, risks, benefits, or design of the studies in which they take part. Research on medical practices, which studies standard interventions rather than new treatments, has the potential to be especially confusing to participants because it is embedded within usual clinical care. Our objective in this randomized study was to compare the ability of a range of multimedia informational aids to improve participant understanding in the context of research on medical practices. Methods: We administered a web-based survey to members of a proprietary online panel sample selected to match national US demographics. Respondents were randomized to one of five arms: four content-equivalent informational aids (animated videos, slideshows with voice-over, comics, and text) and one no-intervention control. We measured knowledge of research on medical practices using a summary knowledge score from 10 questions based on the content of the informational aids. We used analysis of variance and paired t-tests to compare knowledge scores between arms. Results: There were 1500 completed surveys (300 in each arm). Mean knowledge scores were highest for the slideshows with voice-over (65.7%), followed by the animated videos (62.7%), comics (60.7%), text (57.2%), and control (50.3%). Differences between arms were statistically significant except between the slideshows with voice-over and animated videos and between the animated videos and comics. Informational aids that included an audio component (animated videos and slideshows with voice-over) had higher knowledge scores than those without an audio component (64.2% vs 59.0%, p < .0001). There was no difference between informational aids with a character-driven story component (animated videos and comics) and those without. Conclusion: Our results show that simple multimedia aids that use a dual-channel approach, such as voice-over with visual reinforcement, can improve participant knowledge more effectively than text alone. However, the relatively low knowledge scores suggest that targeted informational aids may be needed to teach some particularly challenging concepts. Nonetheless, our results demonstrate the potential to improve informed consent for research on medical practices using multimedia aids that include simplified language and visual metaphors.
An Adaptive Nonlinear Basal-Bolus Calculator for Patients With Type 1 Diabetes
Authors: Boiroux Dimitri , Aradóttir Tinna Björk , Nørgaard Kirsten , Poulsen Niels Kjølstad , Madsen Henrik , Jørgensen John Bagterp 
Published: September 2016

Background: Bolus calculators help patients with type 1 diabetes to mitigate the effect of meals on their blood glucose by administering a large amount of insulin at mealtime. Intraindividual changes in patients physiology and nonlinearity in insulin-glucose dynamics pose a challenge to the accuracy of such calculators. Method: We propose a method based on a continuous-discrete unscented Kalman filter to continuously track the postprandial glucose dynamics and the insulin sensitivity. We augment the Medtronic Virtual Patient (MVP) model to simulate noise-corrupted data from a continuous glucose monitor (CGM). The basal rate is determined by calculating the steady state of the model and is adjusted once a day before breakfast. The bolus size is determined by optimizing the postprandial glucose values based on an estimate of the insulin sensitivity and states, as well as the announced meal size. Following meal announcements, the meal compartment and the meal time constant are estimated, otherwise insulin sensitivity is estimated. Results: We compare the performance of a conventional linear bolus calculator with the proposed bolus calculator. The proposed basal-bolus calculator significantly improves the time spent in glucose target ( P < .01) compared to the conventional bolus calculator. Conclusion: An adaptive nonlinear basal-bolus calculator can efficiently compensate for physiological changes. Further clinical studies will be needed to validate the results.
Distraction First Metatarsophalangeal Arthrodesis With Tricortical Calcaneus Autograft
Authors: McAlister Jeffrey E. , Hyer Christopher F. , Black Trevor E. 
Published: September 2016

First metatarsophalangeal joint arthritis can stem from a biomechanical imbalance as in hallux abducto valgus, metabolic arthritidies such as rheumatoid or gout, and even in posttraumatic cases. Advanced arthritis in the foot and ankle can often become debilitating. Surgical intervention is often necessary. Revision of failed first metatarsophalangeal joint arthroplasty is often in the setting of bony erosion and lysis, cystic changes, and loss of bone stock. In this article, we describe first metatarsophalangeal distraction arthrodesis technique using tricortical calcaneus autograft with the aim of simplifying donor site graft harvesting and decreasing donor site morbidity while attaining successful osseous union. Levels of Evidence: Level V
Effectiveness of Percutaneous Proximal Closing Wedge Osteotomy With Akin Osteotomy to Correct Severe Hallux Valgus Determined by Radiographic Parameters
Authors: Kurashige Toshinori , Suzuki Seiichi 
Published: September 2016

Some authors reported the results from percutaneous distal metatarsal osteotomy for hallux valgus recently. On the other hand, there are few reports of percutaneous proximal metatarsal osteotomy. The purpose of the present study was to evaluate the radiographic results of percutaneous proximal closing wedge osteotomy with Akin osteotomy for correction of severe hallux valgus and increasing longitudinal arch height. Consecutive 17 feet (mean age = 70.8 years) were investigated. The mean follow-up was 22 months. Excision of medial eminence, distal soft tissue release, and Akin osteotomy were all performed percutaneously and concurrently. Weight-bearing anteroposterior and lateral radiographs of the feet were acquired preoperatively and at final follow-up. On the anteroposterior radiographs, hallux valgus angle, intermetatarsal angle, and first metatarsal shortening were measured. On the lateral radiographs, talometatarsal angle, calcaneal pitch angle, and first metatarsal dorsiflexion were measured. The average improvements in hallux valgus angle and intermetatarsal angle were 27.6° and 9.9°, respectively. The average first metatarsal shortening was 2.7 mm. The first metatarsal dorsiflexion improved by 2.2°; however, other parameters did not improve significantly. In conclusion, percutaneous proximal closing wedge osteotomy with Akin osteotomy corrects severe hallux valgus; however, the procedure does not increase the medial longitudinal arch. Levels of Evidence: Therapeutic, Level IV: Case series
Gender differences in the predictive role of self-rated health on short-term risk of mortality among older adults
Authors: Assari Shervin 
Published: September 2016

Objectives: Despite the well-established association between self-rated health and mortality, research findings have been inconsistent regarding how men and women differ on this link. Using a national sample in the United States, this study compared American male and female older adults for the predictive role of baseline self-rated health on the short-term risk of mortality. Methods: This longitudinal study followed 1500 older adults (573 men (38.2%) and 927 women (61.8%)) aged 66 years or older for 3 years from 2001 to 2004. The main predictor of interest was self-rated health, which was measured using a single item in 2001. The outcome was the risk of all-cause mortality during the 3-year follow-up period. Demographic factors (race and age), socio-economic factors (education and marital status), and health behaviors (smoking and drinking) were covariates. Gender was the focal moderator. We ran logistic regression models in the pooled sample and also stratified by gender, with self-rated health treated as either nominal variables, poor compared to other levels (i.e. fair, good, or excellent) or excellent compared to other levels (i.e. good, fair, or poor), or an ordinal variable. Results: In the pooled sample, baseline self-rated health predicted mortality risk, regardless of how the variable was treated. We found a significant interaction between gender and poor self-rated health, indicating a stronger effect of poor self-rated health on mortality risk for men compared to women. Gender did not interact with excellent self-rated health on mortality. Conclusion: Perceived poor self-rated health better reflects risk of mortality over a short period of time for older men compared to older women. Clinicians may need to take poor self-rated health of older men very seriously. Future research should test whether the differential predictive validity of self-rated health based on gender is due to a different meaning of poor self-rated health for older men and women and whether poor self-rated health reflects different health statuses based on gender.
Hereditary risk factors for thrombophilia and probability of venous thromboembolism during pregnancy and the puerperium
Authors: Gerhardt Andrea , Scharf Rüdiger E. , Greer Ian A. , Zotz Rainer B. 
Published: September 2016

Key Points
Women with severe thrombophilia have a high absolute risk of pregnancy-associated VTE independent of a positive family history of VTE. These women should be considered for routine antenatal thromboprophylaxis regardless of family history of VTE.
A hybrid computational strategy to address WGS variant analysis in >5000 samples
Authors: Huang Zhuoyi , Rustagi Navin , Veeraraghavan Narayanan , Carroll Andrew , Gibbs Richard , Boerwinkle Eric , Venkata Manjunath Gorentla , Yu Fuli 
Published: September 2016

Abstract
Background
The decreasing costs of sequencing are driving the need for cost effective and real time variant calling of whole genome sequencing data. The scale of these projects are far beyond the capacity of typical computing resources available with most research labs. Other infrastructures like the cloud AWS environment and supercomputers also have limitations due to which large scale joint variant calling becomes infeasible, and infrastructure specific variant calling strategies either fail to scale up to large datasets or abandon joint calling strategies.

Results
We present a high throughput framework including multiple variant callers for single nucleotide variant (SNV) calling, which leverages hybrid computing infrastructure consisting of cloud AWS, supercomputers and local high performance computing infrastructures. We present a novel binning approach for large scale joint variant calling and imputation which can scale up to over 10,000 samples while producing SNV callsets with high sensitivity and specificity. As a proof of principle, we present results of analysis on Cohorts for Heart And Aging Research in Genomic Epidemiology (CHARGE) WGS freeze 3 dataset in which joint calling, imputation and phasing of over 5300 whole genome samples was produced in under 6 weeks using four state-of-the-art callers. The callers used were SNPTools, GATK-HaplotypeCaller, GATK-UnifiedGenotyper and GotCloud. We used Amazon AWS, a 4000-core in-house cluster at Baylor College of Medicine, IBM power PC Blue BioU at Rice and Rhea at Oak Ridge National Laboratory (ORNL) for the computation. AWS was used for joint calling of 180 TB of BAM files, and ORNL and Rice supercomputers were used for the imputation and phasing step. All other steps were carried out on the local compute cluster. The entire operation used 5.2 million core hours and only transferred a total of 6 TB of data across the platforms.

Conclusions
Even with increasing sizes of whole genome datasets, ensemble joint calling of SNVs for low coverage data can be accomplished in a scalable, cost effective and fast manner by using heterogeneous computing platforms without compromising on the quality of variants.
Ritual, Power, and Pageantry
Authors: Nguyễn Thị Điểu 
Published: September 2016

AbstractColonization should be examined not as a one-way process in which the colonizer unequivocally subdues the colonized but as a fluid phenomenon whereby the so-called subjugated peoples selectively adopt and adapt those elements that best fit their sociocultural traditions. Vietnam in the throes of France's nineteenth-century conquest is an illustrative case. This deeply ritualistic monarchical state was profoundly affected by the imposition of French Republican rituals (Fête de l'Empereur, Quatorze Juillet) that effectively desacralized the Son of Heaven, rendering him a mere mortal, a puppet no longer worthy of devotion. However, the Vietnamese state and people did not merely submit to changes imposed by the French but selectively adopted certain features of the new framework while rejecting its political message. They integrated the Western-imported rituals, which were subsequently transformed into newly invented traditions that would aid them in their struggle for independence and nationhood.Le phénomène de colonisation ne doit pas être compris comme un carcan immuable de subjugation mais comme une manifestation mouvante dans laquelle les peuples colonisés entreprennent eux-mêmes d'intégrer au sein de leurs propres pratiques socioculturelles certaines des mesures coloniales en rejetant toutefois leur message politique. Tel fut le cas du Vietnam, objet de la conquête française au dix-neuvième siècle. La longue tradition rituelle confucéenne de cet état monarchique fut bouleversée par l'imposition d'une politique française de rites issus de la Troisième République qui mit fin à l'aura sacrée du Fils du Ciel. C'est ainsi que furent célébrées en grande pompe des fêtes comme celles du 14 juillet, de Jeanne d'Arc, et cetera, mais qui en s'enracinant en terre asiatique, furent métamorphosées au fil des jours en de nouvelles « traditions » indigènes. Toute empreinte coloniale oubliée, elles vont servir à renforcer la quête de l'indépendance et la formulation d'un Etat-nation moderne.
Mytilus galloprovincialis as a smart micro-pump
Authors: Uslu Fazil E. , Pekkan Kerem 
Published: September 2016

ABSTRACT
Hydrodynamic performance of the marine mussel, Mytilus galloprovincialis, is studied with time-resolved particle image velocimetry. We evaluated inhalant flow, exhalant jet flow, suction performance and flow control capabilities of the mussels quantitatively. Inhalant flow structures of mussels are measured at the coronal plane for the first time in literature. Nutrient fluid is convected into the mussel by three-dimensional sink flow. Inhalant velocity reaches its highest magnitude inside the mussel mantle while it is accelerating outward from the mussels. We calculated pressure gradient at the coronal plane. As inhalant flow approaches the mussel shell tip, suction force generated by the inhalant flow increases and becomes significant at the shell tip. Likewise, exhalant jet flow regimes were studied for 17 mussels. Mussels can control their exhalant jet flow structure from a single potential core region to double potential core region or vice versa. Peak exhalant jet velocity generated by the mussels changes between 2.77 cm s−1 and 11.1 cm s−1 as a function of mussel cavity volume. Measurements of hydrodynamic dissipation at the sagittal plane revealed no interaction between the inhalant and exhalant jet flow, indicating energy-efficient synchronized pumping mechanism. This efficient pumping mechanism is associated with the flow-turning angle between inhalant and exhalant jet flows, ∼90° (s.d. 12°).