bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Everything Happens in the Hallways”: Exploring User Activity in the Corridors at Two Rehabilitation Units
Authors: Colley Jacinta , Zeeman Heidi , Kendall Elizabeth 
Published: October 2017

Objectives: This research aimed to examine the role of the corridors in specialist inpatient rehabilitation units to inform future design of these spaces. Background: In healthcare settings, such as rehabilitation units, corridors have often been designed simply as spaces allowing movement between other locations. However, research suggests that corridors may be places where important social and care-related activities take place. How corridors are used and understood by patients and staff in inpatient rehabilitation settings is unclear, and a greater understanding of the role of corridors in these settings could help to inform more supportive design of these spaces. Methods: Independent observations of user activity were conducted at a major metropolitan inpatient spinal injury unit (SIU) and brain injury unit (BIU). Interviews were conducted with SIU patients ( n = 12), and focus groups were conducted with SIU staff ( n = 23), BIU patients ( n = 12), and BIU staff ( n = 10). Results: Results from the observations showed that the corridors were used frequently across the day, particularly by staff. Thematic analysis of staff and patient experiences found three key themes describing how corridors were used: (1) moving around, (2) delivery and experiences of quality care, and (3) a “spillover space.” Conclusions: Results demonstrate that corridors not only have an important role as connective spaces but are also used as flexible, multipurpose spaces for delivery of quality care and patient experiences. Future design should consider how these spaces can more deliberately support and contribute to patient and staff experiences of rehabilitation.
Fluorarrojadite-(BaNa), BaNa4CaFe13Al(PO4)11(PO3OH)F2, a new member of the arrojadite group from Gemerská Poloma, Slovakia
Authors: Števko Martin , Sejkora Jiří , Uher Pavel , Cámara Fernando , Škoda Radek , Vaculovič Tomáš 
Published: October 2017

ABSTRACTThe new mineral fluorarrojadite-(BaNa), ideally BaNa4CaFe13Al(PO4)11(PO3OH)F2 was found on the dump of Elisabeth adit near Gemerská Poloma, Slovakia. It occurs in hydrothermal quartz veins intersecting highly fractionated, topaz–zinnwaldite S-type leucogranite. Fluorarrojadite-(BaNa) is associated with fluorapatite, ‘fluordickinsonite-(BaNa)’, triplite, viitaniemiite and minor amounts of other minerals. It forms fine-grained irregular aggregates up to 4 cm x 2 cm, which consist of individual anhedral grains up to 0.01 mm in size. It has a yellowish-brown to greenish-yellow colour, very pale yellow streak and a vitreous to greasy lustre. Mohs hardness is ~4½ to 5. The fracture is irregular and the tenacity is brittle. The measured density is 3.61(2) g cm–3 and calculated density is 3.650 g cm–3. Fluorarrojadite-(BaNa) is biaxial (+) and nonpleochroic. The calculated refractive index based on empirical formula is 1.674. The empirical formula (based on 47 O and 3 (OH + F) apfu) is A1(Ba0.65K0.35)Σ1.00 A2Na0.35 B1(Na0.54Fe0.46)Σ1.00 B2Na0.54Ca(Ca0.74Sr0.20Pb0.02Ba0.04)Σ1.00Na2 Na3Na0.46 M(Fe7.16Mn5.17Li0.37Mg0.12Sc0.08Zn0.06Ga0.02Ti0.02)Σ13.00 Al1.02P11O44PO3.46(OH)0.54 W(F1.54OH0.46). Fluorarrojadite-(BaNa) is monoclinic, space group Cc, a = 16.563(1) Å, b = 10.0476(6) Å, c = 24.669(1) Å, β = 105.452(4)°, V = 3957.5(4) Å3 and Z = 4. The seven strongest reflections in the powder X-ray diffraction pattern are [dobs in Å, (I), hkl]: 3.412, (21), 116; 3.224, (37), 206; 3.040, (100), 42$\bar 4$; 2.8499, (22), 33$\bar 3$; 2.7135, (56), 226; 2.5563, (33), 028 and 424; 2.5117, (23), 040. The new mineral is named according to the nomenclature scheme of arrojadite-group minerals, approved by the IMA CNMNC. In fluorarrojadite-(BaNa), Fe2+ is a dominant cation at the M site (so the root-name is arrojadite) and two suffixes are added to the root-name according to the dominant cation of the dominant valence state at the A1 (Ba2+) and B1 sites (Na+). A prefix fluor is added to the root-name as F– is dominant over (OH)– at the W site.
International Assessment of Event-Free Survival at 24 Months and Subsequent Survival in Peripheral T-Cell Lymphoma
Authors: Maurer Matthew J. , Ellin Fredrik , Srour Line , Jerkeman Mats , Bennani N. Nora , Connors Joseph M. , Slack Graham W. , Smedby Karin E. , Ansell Stephen M. , Link Brian K. , Cerhan James R. , Relander Thomas , Savage Kerry J. , Feldman Andrew L. 
Published: October 2017

Purpose Peripheral T-cell lymphomas (PTCLs) have aggressive clinical behavior. We have previously shown that event-free survival (EFS) at 24 months (EFS24) is a clinically useful end point in diffuse large B-cell lymphoma. Here, we assess EFS24 and subsequent overall survival (OS) in large, multinational PTCL cohorts. Patients and Methods Patients with systemic PTCL newly diagnosed from 2000 to 2012 and treated with curative intent were included from the United States and Sweden (initial cohorts) and from Canada (replication cohort). EFS was defined as time from date of diagnosis to progression after primary treatment, retreatment, or death. Subsequent OS was measured after achieving EFS24 or from the time of progression if it occurred within 24 months. OS rates were compared with the age-, sex-, and country-matched general population. Results Seven hundred seventy-five patients were included in the study (the median age at diagnosis was 64 years; 63% were men). Results were similar in the initial and replication cohorts, and a combined analysis was undertaken. Sixty-four percent of patients progressed within the first 24 months and had a median OS of only 4.9 months (5-year OS, 11%). In contrast, median OS after achieving EFS24 was not reached (5-year OS, 78%), although relapses within 5 years of achieving EFS24 occurred in 23% of patients. Superior outcomes after achieving EFS24 were observed in younger patients (≤ 60 years of age: 5-year OS, 91%). Conclusion EFS24 stratifies subsequent outcome in PTCL. Patients with PTCL with primary refractory disease or early relapse have extremely poor survival. However, more than one third of patients with PTCL remain in remission 2 years after diagnosis with encouraging subsequent OS, especially in younger patients. These marked differences in outcome suggest that EFS24 has utility for patient counseling, study design, and risk stratification in PTCL.
Topical 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Corrects Cutaneous Features of Systemic Glucocorticoid Excess in Female Mice
Authors: Tiganescu Ana , Hupe Melanie , Uchida Yoshikazu , Mauro Theadora , Elias Peter M , Holleran Walter M 
Published: October 2017

Abstract
Glucocorticoid (GC) excess drives multiple cutaneous adverse effects, including skin thinning and poor wound healing. The ubiquitously expressed enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activates mouse corticosterone from 11-dehydrocorticosterone (and human cortisol from cortisone). We previously demonstrated elevated 11β-HSD1 activity during mouse wound healing, but the interplay between cutaneous 11β-HSD1 and systemic GC excess is unexplored. Here, we examined effects of 11β-HSD1 inhibition by carbenoxolone (CBX) in mice treated with corticosterone (CORT) or vehicle for 6 weeks. Mice were treated bidaily with topical CBX or vehicle (VEH) 7 days before wounding and during wound healing. CORT mice displayed skin thinning and impaired wound healing but also increased epidermal integrity. 11β-HSD1 activity was elevated in unwounded CORT skin and was inhibited by CBX. CORT mice treated with CBX displayed 51%, 59%, and 100% normalization of wound healing, epidermal thickness, and epidermal integrity, respectively. Gene expression studies revealed normalization of interleukin 6, keratinocyte growth factor, collagen 1, collagen 3, matrix metalloproteinase 9, and tissue inhibitor of matrix metalloproteinase 4 by CBX during wound healing. Importantly, proinflammatory cytokine expression and resolution of inflammation were unaffected by 11β-HSD1 inhibition. CBX did not regulate skin function or wound healing in the absence of CORT. Our findings demonstrate that 11β-HSD1 inhibition can limit the cutaneous effects of GC excess, which may improve the safety profile of systemic steroids and the prognosis of chronic wounds.
Strategies for reducing ovarian dose in volumetric modulated arc therapy (VMAT) for postoperative uterine cervical cancer
Authors: Yoshihiro Ueda , Shingo Ohira , Masaru Isono , Masayoshi Miyazaki , Koji Konishi , Shoji Kamiura , Iori Sumida , Kazuhiko Ogawa , Teruki Teshima 
Published: October 2017

Objective:
To reduce the ovarian dose with volumetric modulated arc therapy (VMAT), an original VMAT was designed with two types of arcs to restrict angles and fields (R-VMAT).

Methods:
The subjects were 11 patients who underwent ovarian transposition with clips left by a surgeon. Three methods, intensity-modulated radiotherapy (IMRT), standard VMAT (S-VMAT) and R-VMAT, were optimized for assessment of the ovarian dose with the target coverage kept high.

Results:
The homogeneity and conformity indexes for the planning target volume (PTV) were similar for the three methods. However, the average ± SD of the ovarian mean dose (OMD) was 5.0 ± 1.5, 4.9 ± 1.9 and 3.5 ± 1.4 Gy, and the percentage of ovarian volume exceeding 5 Gy (V5) was 41.5 ± 34.1%, 34.1 ± 38.05% and 8.4 ± 20.5% for IMRT, S-VMAT and R-VMAT, respectively. The OMD and V5 were significantly smaller for R-VMAT than for the other plans (p &lt; 0.01). Correlation values between the OMD and the lateral distance from the ovaries to the PTV surface were 0.86, 0.81 and 0.82 for IMRT, S-VMAT and R-VMAT, respectively.

Conclusion:
These findings suggest that R-VMAT delivered the lowest dose to the ovaries. To reduce the OMD to less than 3 Gy, ovaries should be transposed laterally 6.1 cm away from the PTV surface when R-VMAT is used.

Advances in knowledge:
When organs with high susceptibility to radiation, such as ovaries, are near the PTV, R-VMAT is superior to IMRT and S-VMAT.
The effect of Mepitel Film on acute radiation-induced skin reactions in head and neck cancer patients: a feasibility study
Authors: Wooding Hayley , Yan Jing , Yuan Ling , Chyou Te-Yu , Gao Shanbao , Ward Iain , Herst Patries M 
Published: October 2017

Objective:
Mepitel Film significantly decreases acute radiation-induced skin reactions in breast cancer patients. Here we investigated the feasibility of using Mepitel Film in head and neck cancer patients (ACTRN12614000932662).

Methods:
Out of a total of 36 head and neck cancer patients from New Zealand (NZ) (n = 24) and China (n = 12) recruited between June 2015 and December 2016, 33 patients complied with protocol. Of these, 11 NZ patients followed a management protocol; 11 NZ patients and 11 Chinese patients followed a prophylactic protocol. An area of the neck receiving a homogenous radiation dose of &gt; 35 Gy was divided into two equal halves; one half was randomized to Film and the other to either Sorbolene cream (NZ) or Biafine cream (China). Skin reaction severity was measured by Radiation Induced Skin Reaction Assessment Scale and expanded Radiation Therapy Oncology Group toxicity criteria. Skin dose was measured by thermoluminescent dosimeters or gafchromic film.

Results:
Film decreased overall skin reaction severity (combined Radiation Induced Skin Reaction Assessment Scale score) by 29% and moist desquamation rates by 37% in the Chinese cohort and by 27 and 28%, respectively in the NZ cohort. Mepitel Film did not affect head movements but did not adhere well to the skin, particularly in males with heavy beard stubble, and caused itchiness, particularly in Chinese patients.

Conclusion:
Mepitel Film reduced acute radiation-induced skin reactions in our head and neck cancer patients, particularly in patients without heavy stubble.

Advances in knowledge:
This is the first study to confirm the feasibility of using Mepitel Film in head and neck cancer patients.
Cervical cancer treated with reduced-volume intensity-modulated radiation therapy base on Sedlis criteria (NCCN VS RTOG)
Authors: Luo Hua-Chun , Lin Gui-Shan , Liao Shao-Guang , Wang Feng-Mei , Cheng Hui-Hua , Feng Jing , Yin Qin , Chen Qun-Hua , Zhu Jin-Feng , Xu Jian-Feng , Wang Dian , Fu Zhi-Chao 
Published: October 2017

Objective:
This study aimed to evaluate the clinical efficacy of different target volumes in pelvic radiotherapy in postoperative treatment of cervical cancer based on the Sedlis criteria.

Methods:
Patients who admitted to our department for post-operative radiotherapy of cervical cancer from December 2001 to December 2011 and met the Sedlis criteria were retrospectively analysed. The incidences of acute and late radiation injuries, and overall, disease-free and tumour-specific survival with reduced-volume pelvic and whole-pelvis radiotherapy were evaluated and compared.

Results:
A total of 371 patients were included in the study, including 239 receiving whole-pelvis radiotherapy and 132 receiving reduced-volume pelvic radiotherapy. The volume of contours for mean PTV volumes, bilateral femoral heads and small intestine volumes in reduced-volume pelvic radiotherapy were lower than whole-pelvis radiotherapy; the results were similar to the V10, V20, V30, V40 and V45 for pelvic bone marrow and small intestine dose volume (both p &lt; 0.05). The acute radiation injury observed in the two groups was mainly haematologic toxicity and upper and lower gastrointestinal symptoms. The incidences of acute radiation injury, and late radiation injury of gastrointestinal and urinary tracts were both significantly lower with reduced-volume pelvic radiotherapy than with whole-pelvis radiotherapy (both p &lt; 0.05). Moreover, there was no significant difference in the incidence of lower extremity oedema, or 2-year or 5-year overall, disease-free or tumour-specific survival between groups (all p &gt; 0.05).

Conclusion:
Reduced-volume pelvic radiotherapy could relieve acute and late radiation injuries, especially myelosuppression, and did not affect long-term survival.

Advanced in knowledge:
Our study shows that reduced-volume base on National Comprehensive Cancer Network 2016 is more fit for cervical cancer than others.
Neither Phoebe nor Cinnamomum – the tetrasporangiate species of Aiouea (Lauraceae)
Authors: Rohde Randi , Rudolph Barbara , Ruthe Kristina , Lorea-Hernández Francisco G. , Moraes Pedro Luis Rodrigues de , Li Jie , Rohwer Jens G. 
Published: October 2017

AbstractCinnamomum is among the largest genera of the Lauraceae, including species from tropical to temperate Asia and from tropical to subtropical America. However, previous studies indicated that Cinnamomum might not be monophyletic in its current circumscription. We therefore re‐investigated the genus and possible relatives with an increased taxon sample, particularly of the Neotropical species. Our results, based on sequences of the nuclear ITS region and the chloroplast spacers psbA‐trnH and trnG‐trnS, show that the Neotropical Cinnamomum species indeed do not form a monophyletic group with the Paleotropical species. Instead, the American species form a clade in which most species of the Neotropical genus Aiouea are nested within several subclades. According to the ITS data the Aiouea/Cinnamomum clade is sister to the likewise predominantly Neotropical Ocoteacomplex, rather than the two Paleotropical Cinnamomum clades. Therefore, Cinnamomum cannot be upheld in its cur‐rent circumscription. As the type C. verum, is from Asia, the Neotropical species need to be placed in a different genus. We decided to transfer them to Aiouea here, because this is the oldest generic name in the Aiouea/Cinnamomum clade, and the only character separating Aiouea from Neotropical Cinnamomum is the number of pollen sacs per anther (di‐ vs. tetrasporangiate), a feature that is known to be variable within several other genera as well. This transfer requires 42 new combinations and two nomina nova. In addition, six species described in the unpublished Ph.D. thesis of one of the authors (FLH) are validated in Aioueahere, and the only species of the genus Mocinnodaphne is transferred to Aiouea as well.
Observational Study of Peripheral Intravenous Catheter Outcomes in Adult Hospitalized Patients: A Multivariable Analysis of Peripheral Intravenous Catheter Failure
Authors: Marsh Nicole , Webster Joan , Larsen Emily , Cooke Marie , Mihala Gabor , Rickard Claire M. 
Published: October 2017

BACKGROUNDAlmost 70% of hospitalized patients require a peripheral intravenous catheter (PIV), yet up to 69% of PIVs fail prior to completion of therapy.OBJECTIVETo identify risk factors associated with PIV failure.DESIGNA single center, prospective, cohort study.SETTINGMedical and surgical wards of a tertiary hospital located in Queensland, Australia.PARTICIPANTSAdult patients requiring a PIV.MEASUREMENTSDemographic, clinical, and potential PIV risk factors were collected. Failure occurred if the catheter had complications at removal.RESULTSWe recruited 1000 patients. Catheter failure occurred in 512 (32%) of 1578 PIVs. Occlusion/infiltration risk factors included intravenous (IV) flucloxacillin (hazard ratio [HR], 1.98; 95% confidence interval [CI], 1.19‐3.31), 22‐gauge PIVs (HR, 1.43; 95% CI, 1.02‐2.00), and female patients (HR, 1.48; 95% CI, 1.10‐2.00). Phlebitis was associated with female patients (HR, 1.81; 95% CI, 1.40‐2.35), bruised insertion sites (HR, 2.16; 95% CI, 1.26‐3.71), IV flucloxacillin (HR, 2.01; 95% CI, 1.26‐3.21), and dominant side insertion (HR, 1.39; 95% CI, 1.09‐1.77). Dislodgement risks were a paramedic insertion (HR, 1.78; 95% CI, 1.03‐3.06). Each increase by 1 in the average number of daily PIV accesses was associated (HR 1.11, 95% CI 1.03‐1.20)–(HR 1.14, 95% CI 1.08‐1.21) with occlusion/infiltration, phlebitis and dislodgement. Additional securement products were associated with less (HR 0.32, 95% CI 0.22‐0.46)–(HR 0.63, 95% CI 0.48‐0.82) occlusion/infiltration, phlebitis and dislodgement.CONCLUSIONModifiable risk factors should inform education and inserter skill development to reduce the currently high rate of PIV failure.
Analysis of Seismicity and Earthquake Energy at Opak Oyo Fault - Yogyakarta
Authors: Wibowo Nugroho Budi , Sembri Juwita Nur 
Published: October 2017

<em>The earthquake that occurred in the Region of Yogyakarta caused by fault activity on the surface, such as Opak-Oyo Fault, Dengkeng Fault, Menoreh Fault and plate tectonic activity in South of Java. Opak-Oyo fault activity reflected from epicenter distribution and earthquake energy. </em><em>This research aims to analyze the earthquake energy which has epicenter around the Opak-Oyo Fault in spatial and temporal. Based on earthquake catalog from 2008 – 2016, there were 66 earthquake with 11 significant event. Epicenter distribution reflected in seismicity map and for the tectonic parameter use least square method. Seismicity map of Opak Oyo Fault area show that distribution of epicenter in the East and Southeast of fault line with the calculation result of b value by least square method is 0.4. In temporal, there is an increasing trend of events in 2008-2015 and decline trend of earthquake in 2015- 2017. Earthquake energy that released in Opak Oyo Fault area has varies value about </em><em>1x10<sup>5.2</sup> – 1x10<sup>12</sup></em><em>joules. Meanwhile, the energy that associated with the existence of Opak Fault Lines has value between </em><em>1x10<sup>5.2</sup> – 1x10<sup>9.6</sup> Joule </em><em>with 10-20 km of hypocenter.The distribution energy has similar pattern with geological formations in that area.</em><p><em> </em></p><p><em><br /></em></p>
Chemical Composition, Antimicrobial, Cytotoxic and Antiplasmodial Activities of Three Sponges from Buton Islands, Indonesia
Authors: Putra Masteria Yunovilsa , Hadi Tri Aryono 
Published: October 2017

GC-MS analysis of the crude extracts of three different species of Indonesian marine sponges has been carried out for identification of bioactive compounds. The GC-MS analysis from Haliclona (Gellius) sp., Lamellodysidea herbacea, and Spheciospongia inconstans revealed the presence of 23, 21, 19 various compounds, respectively and mainly sterols and fatty acids. All the sponge species has been evaluated for antimicrobial activities, cytotoxicity using brine shrimp lethality bioassay and heme polymerization inhibitory activity assay for antiplasmodial activity. In this study, all the sponge species showed antimicrobial activities against at leastone of the test strains. Among them, the extract of sponge Lamellodysidea herbacea displayed activity against two Gram-positive bacteria (S. aureus and B. subtilis) and the Gram-negative bacteria V. cholerae, with inhibition zones of 10.3, 9.2 and 9.5 mm, respectively. The sponge Haliclona (Gellius) sp., showed significant activity against fungal pathogen C. albicans. The sponge Haliclona (Gellius) sp., displayed the ability to inhibit heme polymerization indicating an anti-Plasmodium function and also showed potent cytotoxic activity against the brine shrimp Artemia sp. Keywords: GC-MS analysis, antimicrobial, sponges,bioactive
Deaf people with “no language”: Mobility and flexible accumulation in languaging practices of deaf people in Cambodia
Authors: Moriarty Harrelson Erin 
Published: October 2017

AbstractDeaf people in Cambodia are often represented in the media as lacking language but in reality, deaf people’s repertoires and communicative practices challenge essentialisms regarding modalities and conventional understandings of “language.” Drawing on fieldwork in Cambodia, this article examines how notions of an urban/rural dichotomy devalue the communicative practices of rural deaf people. These ideologies marginalize the creative deployment of various modalities by deaf people in everyday languaging that are not commonly indexed as parts of a linguistic repertoire. Communicative practices such as drawing a picture to communicate, gestures, the use of physical objects such as city maps are devalued because academics and lay people tend to have rigid conceptualizations of language. This article calls for closer attention to modalities such as gestures, the drawing of pictures and the use of physical objects in everyday languaging to interrogate how the “invention” of languages results in distinctions between groups and individuals, especially in terms of access to linguistic resources such as a national signed language and perceptions about the use of modalities other than signing or speaking. In NGO narratives, often echoed by deaf Cambodians themselves, deaf people acquire a signed language only after rural-urban migration, which misrepresents their communicative competencies and creative use of linguistic resources. In reality, deaf people’s linguistic repertoires are constantly expanding as they enter new spaces, resulting in the flexible accumulation of languaging practices and modalities.
Machine learning in laboratory medicine: waiting for the flood?
Authors: Cabitza Federico , Banfi Giuseppe 
Published: October 2017

Abstract
This review focuses on machine learning and on how methods and models combining data analytics and artificial intelligence have been applied to laboratory medicine so far. Although still in its infancy, the potential for applying machine learning to laboratory data for both diagnostic and prognostic purposes deserves more attention by the readership of this journal, as well as by physician-scientists who will want to take advantage of this new computer-based support in pathology and laboratory medicine.