bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency, clinicopathological features and phylogenetic analysis of feline morbillivirus in cats in Istanbul, Turkey
Authors: Yilmaz Huseyin , Tekelioglu Bilge K , Gurel Aydin , Bamac Ozge E , Ozturk Gulay Y , Cizmecigil Utku Y , Altan Eda , Aydin Ozge , Yilmaz Aysun , Berriatua Eduardo , Helps Chris R , Richt Juergen A , Turan Nuri 
Published: January 2017

Objectives The aim of the study was to investigate feline morbillivirus (FmoPV) frequency, phylogeny and associated pathology in cats in Istanbul, Turkey. Methods Samples from sick (n = 96) and dead ( n = 15) cats were analysed using reverse transcription PCR. Blood and urine analyses and histopathology were also performed. Results FmoPV RNA was detected in six cats (5.4%), including three sick (in the urine) and three dead cats (tissues). A significantly greater proportion of FmoPV RNA-positive cats had street access compared with non-infected cats. Blood samples from the morbillivirus-positive cats were negative for morbillivirus RNA. Tubular parenchymal cells, lymphoid and plasma cells in kidney and hepatocytes, lymphoid and plasma cells in liver from dead cats were also positive by immunohistochemistry for the viral N protein. Two FmoPV-positive cats were also positive for feline coronavirus RNA and one cat for feline immunodeficiency virus RNA and feline leukaemia virus proviral DNA. Phylogenetic analysis of the six FmoPV-positive cats showed that the strains were grouped into cluster D and had high similarity (98.5–100%) with strains from Japan and Germany. In the three FmoPV RNA-positive sick cats, respiratory, urinary and digestive system signs were observed as well as weight loss, fever and depression in some cats. Similar clinical signs were also seen in the morbillivirus RNA-negative sick cats. FmoPV RNA-positive cats had lower median red blood cell count, haemoglobin, albumin, albumin/globulin and urobilinogen and higher alanine transaminase, alkaline phosphatase and bilirubin compared with non-infected cats. Significant histopathology of FmoPV RNA-positive dead cats included tubulointerstitial nephritis characterised by severe granular and vacuolar degeneration of the epithelial cells of the cortical and medullary tubules as well as mononuclear cell infiltrates. Widespread lymphoid cell infiltrates were detected in the renal cortex and medullary regions of the kidneys. Cellular infiltration, cholangiohepatitis and focal necrosis in the liver were also found. Although virus-infected cells were found in the kidney and liver of FmoRV RNA-positive cats, tubulointerstitial nephritis, cholangiohepatitis and focal necrosis seen in FmoRV RNA-positive cats were similar to those observed in FmoRV RNA-negative cats. Conclusions and relevance This is the first study to show the presence of FmoPV infection in cats in Turkey. Sick cats, particularly those with kidney disease, should be tested for this virus. The genotypes found in this study were similar to previously reported strains, indicating that circulating morbilliviruses in Turkey are conserved.
Aleglitazar, a dual peroxisome proliferator-activated receptor-α and -γ agonist, protects cardiomyocytes against the adverse effects of hyperglycaemia
Authors: Chen Yan , Chen Hongmei , Birnbaum Yochai , Nanhwan Manjyot K , Bajaj Mandeep , Ye Yumei , Qian Jinqiao 
Published: January 2017

Purpose: To assess the effects of Aleglitazar on hyperglycaemia-induced apoptosis. Methods: We incubated human cardiomyocytes, cardiomyocytes from cardiac-specific peroxisome proliferator-activated receptor-γ knockout or wild-type mice in normoglycaemic or hyperglycaemic conditions (glucose 25 mM). Cells were treated with different concentrations of Aleglitazar for 48 h. We measured viability, apoptosis, caspase-3 activity, cytochrome-C release, total antioxidant capacity and reactive oxygen species formation in the treated cardiomyocytes. Human cardiomyocytes were transfected with short interfering RNA against peroxisome proliferator-activated receptor-α or peroxisome proliferator-activated receptor-γ. Results: Aleglitazar attenuated hyperglycaemia-induced apoptosis, caspase-3 activity and cytochrome-C release and increased viability in human cardiomyocyte, cardiomyocytes from cardiac-specific peroxisome proliferator-activated receptor-γ knockout and wild-type mice. Hyperglycaemia reduced the antioxidant capacity and Aleglitazar significantly blunted this effect. Hyperglycaemia-induced reactive oxygen species production was attenuated by Aleglitazar in both human cardiomyocyte and wild-type mice cardiomyocytes. Aleglitazar improved cell viability in cells exposed to hyperglycaemia. The protective effect was partially blocked by short interfering RNA against peroxisome proliferator-activated receptor-α alone and short interfering RNA against peroxisome proliferator-activated receptor-γ alone and completely blocked by short interfering RNA to both peroxisome proliferator-activated receptor-α and peroxisome proliferator-activated receptor-γ. Conclusion: Aleglitazar protects cardiomyocytes against hyperglycaemia-induced apoptosis by combined activation of both peroxisome proliferator-activated receptor-α and peroxisome proliferator-activated receptor-γ in a short-term vitro model.
Evaluating place-based job creation programs in Japan
Authors: Kazekami Sachiko 
Published: January 2017

Abstract
First, this paper empirically evaluates the incidence of the Japanese place-based job creation program, which has rarely been studied in Japan. The program increases employment, especially in the agricultural, retail trade, and service sectors, which most treated municipalities promote. Second, this paper explores the municipalities that the program affects most. Those with large aging populations and those with small working age populations decrease the effects of the program. Third, this paper assesses the externality effect of this program and does not observe a strong reduction in sales, workers, or establishments in the neighboring municipalities of a treated municipality.
Persistent proteinuria as an indicator of renal disease in HIV-infected children
Authors: Hisbiiyah Yuni , Prasetyo Risky Vitria , Puspitasari Dwiyanti , Soemyarso Ninik Asmaningsih , Moedjito Ismoedijanto , Noer Mohammad Sjaifullah 
Published: January 2017

Background Persistent proteinuria (microalbuminuria) has been reported to be a precursor of HIV-related renal disease. Screening allows for early management in order to prevent the progression of renal disease and decrease morbidity and mortality associated with chronic kidney disease in HIV. Several studies have been done on renal manifestation in HIV-infected children from American and African regions, but similar studies from Asia are lacking.Objective To determine the prevalence of persistent proteinuria in HIV-positive children on antiretroviral therapy (ARV) in Dr. Soetomo Hospital, Surabaya.Methods A cross-sectional study on children with HIV and treated with highly active antiretroviral therapy (HARRT) was done from August 2014 to February 2015. Microalbuminuria was measured by the ratio of urine albumin to creatinine (ACR), while proteinuria was measured by dipstick. Measurements were performed 3 times in 4-8 weeks. All subjects underwent complete evaluation of blood tests, serum creatinine, blood urea nitrogen (BUN), CD4 counts, and urinalysis. Data were analyzed using Chi-square and logistic regression tests.Results Of 38 children on HARRT enrolled in this study, 2 subjects developed acute kidney injury (AKI), 4 subjects were suspected to have urinary tract infection (UTI), and 1 subject was suspected to have urinary tract stones. The prevalence of persistent microalbuminuria was 2.6%. There was no correlation between immunological status, WHO clinical stage, or duration of ARV and the incidence of persistent proteinuria (P>0.05).Conclusion The prevalence of persistent proteinuria is lower in younger HIV-infected children at a non-advanced stage and HIV-infected children with normal immunological status who are on HAART. We provide baseline data on the renal conditions of HIV-infected children in the era of HAART, before tenovofir is increasingly used as an antiretroviral therapy regimen in Indonesia.
Skor Prediksi Kematian Pneumonia pada Anak Usia di Bawah Lima Tahun
Authors: Latumahina Ambarsari , Triasih Rina , Hermawan Kristia 
Published: January 2017

Latar belakang. Pneumonia merupakan penyebab utama kematian pada anak usia di bawah lima tahun di negara berkembang. Pengembangan sistem skor yang sederhana untuk memprediksi kematian pada pneumonia dapat meningkatkan kualitas pelayanan dan menurunkan angka kematian anak akibat pneumonia.Tujuan. Menyusun skor prediksi kematian pada anak dengan pneumonia.Metode. Penelitian kohort retrospektif pada anak (umur 2 bulan sampai 5 tahun) yang dirawat di RSUP Dr. Sardjito dengan pneumonia sejak Januari 2009 sampai Desember 2014. Anak dengan rekam medis tidak lengkap atau dengan infeksi HIV dieksklusi. Digunakan metode Spiegelhalter Knill-Jones untuk penyusunan skor kematian. Prediktor kematian dengan likelihood ratio (LHR) ≤0,5 atau ≥2 dimasukkan dalam sistem skor. Cut off point dari skor total ditentukan dengan kurva receiver operating characteristic (ROC).Hasil. Di antara 225 anak yang memenuhi kriteria, 42 (18,7%) meninggal. Prediktor kematian yang memenuhi kriteria LHR adalah usia <6 bulan (LHR 2,05), takikardia (LHR 2,11), saturasi oksigen (SpO2) <92% (LHR 2,54), anemia (LHR 0,38) dan leukositosis (LHR 2,04). Skor prediksi kematian terdiri atas usia (skor=5 bila usia <6 bulan dan 0 bila >6 bulan); frekuensi nadi skor=6 bila takikardia dan -8 bila normal); saturasi oksigen (skor=3 bila SpO2 <92% dan 0 bila SpO2 >92%); hemoglobin (skor=4 bila anemia dan -6 bila normal), leukosit (skor=3 bila leukosit dan 0 bila normal). Total skor >3 Mempunyai sensitivitas dan spesifitas terbaik, yaitu 85,7% dan 72,1%.Kesimpulan. Skor prediksi kematian pneumonia >3 dapat digunakan untuk memprediksi kematian pada anak dengan pneumonia.
Home range of a male jaguar spatially associated with the landfill of the city of Playa del Carmen, Mexico
Authors: González-Gallina Alberto , Hidalgo-Mihart Mircea G. , Pérez-Garduza Freddy , Iglesias-Hernández Jesús A. , Oliveras de Ita Adán , Chacón-Hernández Andrés , Vázquez-Zúñiga Octavio 
Published: January 2017

Abstract
Understanding how jaguars (Panthera onca) adapt to disturbed landscapes, especially urbanized areas, can help us prevent adverse situations, thus reducing conflict, and perhaps even achieve coexistence with these predators. Playa del Carmen, a city located in the middle of a natural corridor linking two jaguar conservation units (JCUs; Sian Ka’an and Yum Balam), is facing intense pressure from tourism-related city growth. From January 2013 to March 2014, we tracked an adult male jaguar using a satellite collar and found that the presence of the Playa del Carmen landfill had a clear influence on a male jaguar’s home range and movements. We observed that this particular jaguar had the smallest seasonal home range and core areas reported in the literature (particularly during the dry season in 2013, where the home range was only 16.22 km2 and the core area was 2.5 km2) and also that the seasonal core areas overlapped with the area covered by the landfill (with a number of important locations within the landfill). Our results showed that male jaguars are surviving in areas previously not considered as jaguar habitat and are taking advantage of the human resources within. We hope that these results encourage more jaguar studies to be carried out in areas disturbed by human activities.
Drying Behavior of Mature Fine Tailings Pre-Dewatered With Super-Absorbent Polymer (SAP): Column Experiments
Authors: Roshani A. , Fall M. , Kennedy K. 
Published: January 2017

Abstract
Laboratory column experiments were conducted to investigate the effect of super-absorbent polymer (SAP) on the drying behavior (e.g., dewatering, strength, suction, settlement) of mature fine tailing (MFT). Four experimental columns filled in two different stages with dewatered MFT of 1 wt. % SAP were subjected to atmospheric drying. Moreover, four additional columns (control columns) filled with raw MFT (not pre-dewatered with SAP) were also subjected to drying. The rate of evaporation, drainage, settlement and evolution of suction, strength and void ratio were monitored or determined in a 30-day period. Promising results have been obtained. The results show that the rate of evaporation for SAP pre-dewatered samples was lower than that of raw MFT. Cumulative water lost via evaporation decreased from 13 kg for raw MFT to 7.2 kg for pre-dewatered MFT, which is because of the lower water content of the pre-dewatered MFT. Water drainage for pre-dewatered MFT showed 82 % reduction in comparison with raw MFT within the test period. This finding suggests that the use of SAP pre-dewatered method could considerably reduce the seepage of toxic water from the tailings and MFT impoundments. Developed suction in the first lift showed a sharp reduction by loading the second lift because of redistribution of pore water but this effect was temporary and developed suction in the second lift gained strength. Vane shear strength of pre-dewatered MFT after 30 days was around 3.6 kPa and 7.3 kPa for 5-cm (bottom) and 15-cm heights, respectively, and the strength of the upper parts reached 2.3 MPa. SAP pre-dewatered MFT had a much higher strength increase rate at early ages than the raw MFT. After 10 days of drying, the undrained shear strength at all column heights exceeded or was close to the 1-year value (5 kPa) required by environmental regulations set by the Energy Resources Conservation Board (ERCB). This could have significant practical implication with respect to accelerating the dewatering process and consolidation of MFT, thus increasing the pace of reclamation, reducing the cost of the tailing management and reducing the environmental footprint of heavy oil operations.
Interrelationships of Flat Rigid Dilatometer Parameters With Unconfined Compression Test Results
Authors: Aziz M. , Akbar A. 
Published: January 2017

Abstract
The flat dilatometer has been frequently used for soil investigations in engineering practice because of its simplicity, rapid and repetitive use. This paper described the calibration of a flat rigid dilatometer (NDMT) in a low to medium plasticity cohesive soil. The discussion concentrated on the comparison of soil classification, unit weight, undrained shear strength, and stiffness of the soil determined through NDMT tests and unconfined compressive strength (UCS) tests. Based on the geotechnical characterization of the test bed, an attempt was made to establish the usefulness of NDMT for in situ testing of widespread cohesive soil deposits in the Punjab province of Pakistan. Correlations have been proposed between NDMT parameters and UCS test results to estimate necessary soil properties for site characterization and design of foundations on such soils.
Sudden cardiac arrest risk in young athletes
Authors: Gradidge PJ-L , Constantinou D , Goldberg L 
Published: January 2017

Underlying cardiac abnormalities are the main cause of unexpected death in athletes on field. These abnormalities have been associated with a previous history of syncope, a family history of sudden cardiac arrest (SCA), cardiac murmur, a history of over-exhaustion post exercise and ventricular tachyarrhythmia during physical activity. The timely diagnosis of susceptible athletes may assist with an appropriate management plan for these individuals, and allow for the prevention of premature death in sport. A young football player was screened for SCA risk using the fundamental components of the pre-participation examination (PPE) – essentially, a medical history, a resting and stress electrocardiogram, and an echocardiogram to support clinical findings. The case is submitted with consideration of the applicable literature to accentuate the importance of using PPE to prevent SCA in young athletes.
Soil fertility constraints and yield gaps of irrigation wheat in South Africa
Authors: Sosibo Nondumiso Z. , Muchaonyerwa Pardon , Visser Lientjie , Barnard Annelie , Dube Ernest , Tsilo Toi J. 
Published: January 2017

South Africa currently faces a wheat (Triticum aestivum L.) crisis as production has declined significantly over the past few years. The objective of this study was to explore opportunities for improving yields in intensive irrigated wheat production systems of South Africa through analyses of yield gaps, soil fertility constraints and conservation agriculture practices. The study was conducted in the major irrigation wheat production areas across four geographical regions: KwaZulu-Natal, eastern Highveld, warmer northern and cooler central. Actual yield (Ya) based on long-term yield data ranged from 5.99±0.15 t/ha to 8.32±0.10 t/ha across different geographical regions. The yield potential (Yp) ranged from 7.57 t/ha to 11.45 t/ha. Yield gaps (Yp–Ya) were in the range of 1.58–3.13 t/ha. Yields could be increased by 26–38% through closing yield gaps. On 88.37% and 13.89% of the fields in the KwaZulu-Natal and warmer northern regions, respectively, there was strong evidence of the practise of conservation agriculture, but none in the other regions. On 42.31% of irrigated wheat fields, soil organic carbon was below 1% at a soil depth of 0–20 cm. Fields in which conservation tillage was practised had double the soil organic carbon of conventionally tilled fields (2.15±0.10% versus 1.02±0.05%), but greater acidity and phosphorus deficiency problems. Sustainable approaches for addressing phosphorus deficiency and acidity under conservation tillage practices need to be sought, especially in the KwaZulu-Natal region.

Significance:

Opportunities for improving wheat yields in South Africa need to be explored to address the wheat crisis.
Sustainable approaches for addressing phosphorus deficiency and acidity of soil under conservation tillage practices need to be sought, especially in the KwaZulu-Natal region.
POR QUE CULTURA SURDA?: Sentidos e significados na educação de alunos surdos
Authors: Cavalcante Anissa Ayala Rocha da Silva , Costa Valdelúcia Alves da 
Published: January 2017

Na intenção de discutir sobre a educação de alunos surdos na perspectiva da educação bilíngue, fez-se necessário refletir sobre as concepções de cultura ao longo das experiências sociais vividas pela humanidade; assim como sobre a questão da constituição das identidades no mundo globalizado e administrado pela lógica capitalista. Foi considerada a Teoria Crítica da Sociedade como referencial de análise e a escola como espaço de reflexão e crítica às ações de dominação cultural, visando compreender suas causas e, assim, não permitir sua reprodução, como também foi considerada a educação de alunos surdos que respeite as singularidades da língua e cultura da comunidade surda e o bilinguismo como opção metodológica de atendimento às demandas dos alunos surdos na organização de escolas bilíngues.Palavras-chave: Cultura surda. Educação bilíngue. Alunos surdos.WHY DEAF CULTURE?: Senses and meanings in the education of deaf studentsAbstract: In order to discuss about education of deaf students from the perspective of bilingual education, it was necessary to reflect on the conceptions of culture throughout the social experiences lived by mankind; As well as on the question of the constitution of identities in the globalized world and administered by the capitalist logic. The Critical Theory of Society was considered as a reference for analysis and the school as a space for reflection and criticism of the actions of cultural domination, aiming at understanding its causes and, therefore, not allowing its reproduction, but also considering the perspective of education of deaf students which respects the singularities of the language and culture of the deaf community and bilingualism as a theoretical-methodological option to meet the demands of deaf students in the organization of bilingual schools.Keywords: Deaf culture. Bilingual education. Deaf students.¿POR QUÉ LA CULTURA SORDA?: Sentidos y significados en la educación de los alumnos sordosResumen: Con la intención de discutir la formación de los alumnos sordos en el contexto de la educación bilingüe, fue necesario reflexionar sobre las concepciones de la cultura a través de las experiencias sociales vividas por la humanidad; así como sobre la cuestión de la constitución de las identidades en un mundo globalizado y administrado por la lógica capitalista. Se consideró la Teoría Crítica de la Sociedad como aporte de análisis y la escuela como un espacio de reflexión y crítica de las acciones de la dominación cultural con el fin de comprender sus causas y, por lo tanto, no permitir su reproducción, como también se consideró la educación de alumnos sordos que respete las singularidades de la lengua y la cultura de la comunidad sorda y el bilingüismo como una opción metodológica en el atendime nto de las demandas de los alumnos sordos en la organización de las escuelas bilingües. Palabras clave: Cultura sorda. Educación bilíngue. Alumnos sordos.
Analysis of risk of congenital malformations of musculoskeletal
system in Silesia region in comparison to rest of Polish territory
Authors: Gwiazda Wioleta , Balcerzyk Anna , Niemiec Paweł , Iwanicka Joanna , Tatarka Joanna , Żak Iwona 
Published: January 2017

WstępWrodzone wady rozwojowe występują u ok. 2–4% noworodków. W Polsce od 1997 roku działa Polski Rejestr Wrodzonych Wad Rozwojowych, który pozwala na ich monitorowanie w populacji polskiej. Analiza regionalnych różnic w częstości występowania wad wrodzonych może mieć istotne znaczenie w poszukiwaniu czynników ryzyka oraz analizie działań profilaktycznych na danym terenie.
Celem niniejszej pracy była ocena ryzyka urodzeń noworodków z wrodzonymi wadami rozwojowymi układu mięśniowo-szkieletowego w województwie śląskim w odniesieniu do pozostałego obszaru Polski objętego rejestrem.Materiał i metodyPraca powstała na bazie danych pochodzących z Polskiego Rejestru Wrodzonych Wad Rozwojowych z lat 2001–2006. Grupę badaną stanowiły zgłoszone do rejestru dzieci do 2 r.ż., u których rozpoznano wadę rozwojową, dzieci martwo urodzone z wadą oraz te, u których rozpoznano wadę w okresie prenatalnym. Wszystkie analizy statystyczne przeprowadzono przy użyciu oprogramowania Epi Info 7.WynikiCzęstość wystąpienia wrodzonych wad rozwojowych układu mięśniowo-szkieletowego na terenie województwa śląskiego była wyższa niż na pozostałym obszarze Polski we wszystkich analizowanych latach, z wyjątkiem roku 2003. Największy wzrost ryzyka stwierdzono w przypadku wad Q68 oraz Q67. Częstość wrodzonych wad na Śląsku wykazywała tendencję spadkową w kolejnych latach od 2001 do 2006.WnioskiWrodzone wady rozwojowe układu mięśniowo-szkieletowego występowały częściej na terenie województwa śląskiego, niż na pozostałym obszarze Polski we wszystkich analizowanych latach, z wyjątkiem roku 2003.