bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low expression of miR-192 in NSCLC and its tumor suppressor functions in metastasis via targeting ZEB2
Authors: Yunxia Zhang , Hongying Dong 
Published: November 2016

AbstractObjectivesLung cancer is the leading cause of cancer-related death, with non-small cell lung cancer (NSCLC) accounting for more than 80% of all lung cancer cases. The aim of this study was to investigate the function and underlying mechanism of microRNA-192 (miR-192) in metastasis of NSCLC cells.MethodsReal-time PCR was applied to quantify the expression of miR-192 in NSCLC tissues and cell lines, matched with their corresponding controls. The biological roles of miR-192 were studied in NSCLC cells using the wound healing and trans well invasion assays. Real-time PCR and western blot were used to evaluate the regulation of ZEB2 by miR- 192.ResultsMiR-192 was expressed significantly lower in NSCLC tissues/cells when compared with controls. Ectopic expression of miR-192 strongly inhibited cell migration and invasion in NSCLC A549 cells. Further investigation revealed ZEB2, an EMT regulator, was one of the downstream targets regulated by miR-192.ConclusionThese results suggested that miR-192 inhibits the metastasis of NSCLC cells by targeting ZEB2, and thus is an important tumor suppressor.
Advanced glycation end products mediated cellular and molecular events in the pathology of diabetic nephropathy
Authors: Kumar Pasupulati Anil , Chitra P. Swathi , Reddy G. Bhanuprakash 
Published: November 2016

AbstractDiabetic nephropathy (DN) is a major cause of morbidity and mortality in diabetic patients and a leading cause of end-stage renal disease (ESRD). Degenerative changes such as glomerular hypertrophy, hyperfiltration, widening of basement membranes, tubulointerstitial fibrosis, glomerulosclerosis and podocytopathy manifest in various degrees of proteinuria in DN. One of the key mechanisms implicated in the pathogenesis of DN is non-enzymatic glycation (NEG). NEG is the irreversible attachment of reducing sugars onto free amino groups of proteins by a series of events, which include the formation of Schiff’s base and an Amadori product to yield advanced glycation end products (AGEs). AGE modification of client proteins from the extracellular matrix induces crosslinking, which is often associated with thickening of the basement membrane. AGEs activate several intracellular signaling cascades upon interaction with receptor for AGEs (RAGE), which manifest in aberrant cellular responses such as inflammation, apoptosis and autophagy, whereas other receptors such as AGE-R1, AGE-R3 and scavenger receptors also bind to AGEs and ensue endocytosis and degradation of AGEs. Elevated levels of both serum and tissue AGEs are associated with adverse renal outcome. Increased evidence supports that attenuation of AGE formation and/or inhibition of RAGE activation manifest(s) in improving renal function. This review provides insights of NEG, discusses the cellular and molecular events triggered by AGEs, which manifest in the pathogenesis of DN including renal fibrosis, podocyte epithelial-mesenchymal transition and activation of renin-angiotensin system. Therapies designed to target AGEs, such as inhibitors of AGEs formation and crosslink breakers, are discussed.
Performance evaluation of ImmunoCAP® ISAC 112: a multi-site study
Authors: van Hage Marianne , Schmid-Grendelmeier Peter , Skevaki Chrysanthi , Plebani Mario , Canonica Walter , Kleine-Tebbe Jörg , Nystrand Mats , Jafari-Mamaghani Mehrdad , Jakob Thilo 
Published: November 2016

AbstractBackground:After the re-introduction of ImmunoCAPMethods:The study was carried out at 22 European and one South African site. Microarrays from different batches, eight specific IgE (sIgE) positive, three sIgE negative serum samples and a calibration sample were sent to participating laboratories where assays were performed according to the manufacturer’s instructions.Results:For both the negative and positive samples results were consistent between sites, with a very low frequency of false positive results (0.014%). A similar pattern of results for each of the samples was observed across the 23 sites. Homogeneity analysis of all measurements for each sample were well clustered, indicating good reproducibility; unsupervised hierarchical clustering and classification via random forests, showed clustering of identical samples independent of the assay site. Analysis of raw continuous data confirmed the good accuracy across the study sites; averaged standardized, site-specific ISU-E values fell close to the center of the distribution of measurements from all sites. After outlier filtering, variability across the whole study was estimated at 25.5%, with values of 22%, 27.1% and 22.4% for the ‘Low’, ‘Moderate to High’ and ‘Very High’ concentration categories, respectively.Conclusions:The study shows a robust performance of the ImmunoCAP
Antiphosphatidylserine/prothrombin antibodies as biomarkers to identify severe primary antiphospholipid syndrome
Authors: Hoxha Ariela , Mattia Elena , Tonello Marta , Grava Chiara , Pengo Vittorio , Ruffatti Amelia 
Published: November 2016

Abstract

Background:
Anti-phosphatidylserine/prothrombin (aPS/PT) antibodies have begun to be considered potentional biomarkers for antiphospholipid syndrome (APS). This cohort study investigate the role of aPS/PT antibodies as a risk factor for severe APS by evaluating the association between those antibodies and clinical/laboratory profiles of APS.

Methods:
Plasma/serum samples from 197 APS patients, 100 healthy subjects and 106 patients with autoimmune diseases were collected. IgG/IgM aPS/PT antibodies were assayed using commercial ELISA kit.

Results:
Prevalences of IgG and IgM aPS/PT (p<0.0001 and p=0.0009, respectively) and their titres (p<0.0001 and p=0.0002, respectively) were significantly higher in thrombosis/pregnancy group with respect to pregnancy morbidity alone. Prevalences of IgG and IgM aPS/PT (p<0.0001 and p=0.0004, respectively) and their mean levels (p=0.0001 for both) were significantly higher in the prematurity linked to life-threatening obstetric complications group with respect to miscarriage group. There was a significant relationship between IgG and IgM aPS/PT (p=0.001 and p=0.0002) and their mean levels were higher (p=0.0004 and p=0.0002, respectively) in the thrombotic microangiopathy group, considered a milestone manifestation of catastrophic APS. The relationship between IgG and IgM aPS/PT was significant and mean levels were higher in triple positive antiphospholipid antibody patients than in double and single positivity ones (p<0.0001 for all).

Conclusions:
APS/PT antibodies were associated to severe thrombosis, severe pregnancy complications inducing prematurity, and vascular microangiopathy, all generally associated to high risk APS forms requiring strong therapy.
Molecular Dynamics Simulation of Cholera Toxin A-1 Polypeptide
Authors: Badshah Syed Lal , Khan Abdul Naeem , Mabkhot Yahia Nasser 
Published: November 2016

AbstractA molecular dynamics (MD) simulation study of the enzymatic portion of cholera toxin; cholera toxin A-1 polypeptide (CTA1) was performed at 283, 310 and 323 K. From total energy analysis it was observed that this toxin is stable thermodynamically and these outcomes were likewise confirmed by root mean square deviations (RMSD) investigations. The Cα root mean square fluctuation (RMSF) examinations revealed that there are a number of residues inside CTA1, which can be used as target for designing and synthesizing inhibitory drugs, in order to inactivate cholera toxin inside the human body. The fluctuations in the radius of gyration and hydrogen bonding in CTA1 proved that protein unfolding and refolding were normal routine phenomena in its structure at all temperatures. Solvent accessible surface area study identified the hydrophilic nature of the CTA1, and due to this property it can be a potential biological weapon. The structural identification (STRIDE) algorithm for proteins was successfully used to determine the partially disordered secondary structure of CTA1. On account of this partially disordered secondary structure, it can easily deceive the proteolytic enzymes of the endoplasmic reticulum of host cells.
From expectation to concepts: Toward multilevel grounding in musical semantics
Authors: Antović Mihailo 
Published: November 2016

AbstractThis paper initiates a theory of musical semantics based on the notions ofcross-domain mappingfrom cognitive linguistics andgroundfrom the philosophy of language. The central claim is that listeners construct musical meaning on the basis of neither free associations nor fixed clues inherent to the musical structure. Rather, the process is grounded in a hierarchical system of six contextual constraints. On level one, the first glimpse of meaning emerges from directphysiologicalreactions, as when a segment of music is described as “tense.” On level two,image-schematicstructure begins to be constructed, e. g., a “hopping” staccato. Level three isconnotational, ascribing emotional qualities to the music, while on level four, the meaning becomesconceptual, relating the music to rich imagery, e. g., “a medieval battle.” On level five, conceptual meaning interacts with an elaboratedcultural context, motivating rich descriptions at the intersection of two or more conceptual domains, e. g., when the “battle” is replaced by “gods coming down from Olympus.” Level six hosts associations grounded in personal experience. To support the proposal, a representative set of verbal descriptions from a recent experimental study on musical meaning is analyzed, showing both the emergence of new conceptual content and the hierarchical nature of grounding. In doing so, the contribution attempts to formally capture the old paradox of musical semantics: that music is full of meaning, yet that this meaning is highly underspecified, manifested in apotentialrather than definite form.
Complex geophysical investigation of the Kapušany landslide (Eastern Slovakia)
Authors: Kušnirák David , Dostál Ivan , Putiška René , Mojzeš Andrej 
Published: November 2016

Abstract
Geophysical survey is a very useful and popular tool used by engineering geologists to examine landslides. We present a case study from the Kapušany landslide, Eastern Slovakia, where a broad spectrum of geophysical methods were applied along two perpendicular profiles in order to compare the ability of the methods to detect as many structural features of the landslide as possible. The 2D Electrical Resistivity Tomography inverse model was capable of defining the geological structure of the landslide and defining the shear zone, however the resolution of the inverse model does not allow us to identify cracks or other minor features of the landslide. These, however, were well recorded in the results of Dipole Electromagnetic Imaging and the Self Potential method. In addition microgravimetry, Gamma-Ray Spectrometry and Soil Radon Emanometry were experimentally employed to validate the results obtained from electrical methods and afterwards final geological models, based on the integrated interpretation of all involved methods were constructed.
Kodaira dimension of moduli of special cubic fourfolds
Authors: Tanimoto Sho , Várilly-Alvarado Anthony 
Published: November 2016

Abstract
A special cubic fourfold is a smooth hypersurface of degree 3 and dimension 4 that contains a surface not homologous to a complete intersection. Special cubic fourfolds give rise to a countable family of Noether–Lefschetz divisors

𝒞
d

{{\mathcal{C}}_{d}}

in the moduli space

𝒞

{{\mathcal{C}}}

of smooth cubic fourfolds. These divisors are irreducible 19-dimensional varieties birational to certain orthogonal modular varieties. We use the “low-weight cusp form trick” of Gritsenko, Hulek, and Sankaran to obtain information about the Kodaira dimension of

𝒞
d

{{\mathcal{C}}_{d}}

. For example, if

d
=

6
⁢
n

+
2

{d=6n+2}

, then we show that

𝒞
d

{{\mathcal{C}}_{d}}

is of general type for

n
>
18

{n>18}

,

n
∉

{
20
,
21
,
25
}

{n\notin\{20,21,25\}}

; it has nonnegative Kodaira dimension if

n
>
13

{n>13}

and

n
≠
15

{n\neq 15}

. In combination with prior work of Hassett, Lai, and Nuer, our investigation leaves only twenty values of d for which no information on the Kodaira dimension of

𝒞
d

{{\mathcal{C}}_{d}}

is known. We discuss some questions pertaining to the arithmetic of K3 surfaces raised by our results.
Electoral Behaviour’s Conditionality of Young People in Communal Elections (The Example from Surveyed University Students in Constantine the Philosopher University)
Authors: Michvocíková Veronika 
Published: November 2016

Abstract
The exploration of electoral behaviour’s conditionality of young people is based on the theoretical and empirical exploitation of their approach. Theoretical definitions of the communal politics’ knowledge are needed for their empirical analysis. Theoretical part of the present issue contents definitions of key words. Key words are connected with the communal politics’ area. Specifically, we need to define politics. It is also necessary to specify politics’ role in the contemporary society. This issue focusses on the communal politics. It also specifies the basic aim of the communal politics and it also defines communal politics’ objectives and specifications. At last, there is also described the participation of individuals on communal politics’ formation and development. Generally, the citizens are considered to be actors of the communal politics. Therefore, it is necessary to focus on the conditions of the individuals’ participation on electoral process. Communal politics’ empirical exploration is characterised by the conditionality of the individuals’ participation on electoral process in their residence. In this context, it is important to deal with the impact of individual aspects on the voter decisions of individuals. In the society, there are various groups of people. Young people are one of the significant sociable groups. They gradually incorporate into decision processes. Decision processes affect young people’s existence of daily life. Their decisions are determined by the exposure of general factors of the socialization. Therefore, it is important to explore determinants of the young people’s participation on communal politics. According to this, 180 students on Constantine the Philosopher University in Nitra attended the survey Received data were processed Statistical Software SPSS 20 by univariate, bivariate and multivariate data’s analysis.
Guided by the light: Roost choice and behaviour of urban Rainbow Lorikeets (Trichoglossus haematodus)
Authors: Daoud-Opit Savannah , Jones Darryl N. 
Published: November 2016

Abstract
1. The formation of large communal roosts is a conspicuous phenomenon associated with a wide range of bird species successfully exploiting urban environments. In many Australian cities, the abundance of the Rainbow Lorikeet (Trichoglossus haematodus), a native parrot, has increased markedly in recent decades, with the species roosting in very large numbers within suburban sites. These roosting locations are noisy and cause significant fouling of the land beneath, resulting in conflict with humans.
2. We investigated the selection of roosting sites in this species in Brisbane, Australia, by comparing characteristics of both the general sites of these roosts as well as individual trees used within roosting sites and trees that were avoided.
3. Lorikeets used a wide variety of tree types for roosting but demonstrated a clear preference for clumped trees within sparsely treed areas that received significantly more artificial light at night than otherwise suitable sites and trees nearby.
4. These features of roosting sites may enhance the detection of nocturnal predators by Rainbow Lorikeets, suggesting a potential positive impact of anthropogenic lighting. Our findings provide valuable insights into the management of roost-related conflicts in urban areas. We encourage further investigations into the possible benefits of artificial light.
Overlooked Opportunity: Trade in Services
Authors: Jensen J. Bradford 
Published: November 2016

Abstract
Politicians love the manufacturing sector (almost as much as they love farmers). The current administration has in place a number of programs to support the manufacturing and set as a goal to “create one million new manufacturing jobs by the end of 2016.” (Bogage, Jacob. “Obama’s elusive promise to add one million new manufacturing jobs,” Washington Post, May 5, 2016. Source: https://www.washingtonpost.com/business/economy/obamas-elusive-promise-to-deliver-1-million-new-manufacturing-jobs/2016/05/05/717d8cd0-107a-11e6-93ae-50921721165d_story.html.) The current administration is not alone, both major party presidential nominees also have policies to focus on the manufacturing sector – often involving some type of change to US trade policy. Clinton has back-tracked on the Trans-Pacific Partnership trade agreement and Trump goes further to propose applying 45 percent tariffs on goods from China and 35 percent on goods from Mexico – all seemingly with an eye to aiding the manufacturing sector. While a rebound in the manufacturing sector would be welcome, it is unlikely to have a material impact on the aggregate US employment picture – in 2012, manufacturing accounted for only about 8 percent of the labor force. Worse, focusing on the manufacturing sector diverts attention from a real opportunity: trade in services. The United States has a significant opportunity for increased growth through exports of business services. Global trade increased almost 7-fold over the period 1980–2010. Services share of world trade has increased from about 15 percent in 1980 to 20 percent in 2010. The United States share of global services trade has grown from about 10 percent in 1980 to 14 percent in 2010 – a growing share of a growing pie (World Trade Organization website. http://www.wto.org/english/res_e/statis_e/trade_data_e.htm.). The growing middle-class in emerging economies will likely combine to increase demand for services globally [Eichengreen and Gupta (2009) demonstrate a strong correlation between GDP per capita and the share of business services in GDP, suggesting that rising incomes are associated with increased demand for services.].
Univalence in locally cartesian closed ∞-categories
Authors: Gepner David , Kock Joachim 
Published: November 2016

Abstract
After developing the basic theory of locally cartesian localizations of presentable locally cartesian closed

∞

${\infty}$

-categories,
we establish the representability of equivalences and show that univalent families, in the sense of Voevodsky, form a poset isomorphic to the poset of bounded local classes, in the sense of Lurie.
It follows that every

∞

${\infty}$

-topos has a hierarchy of “universal” univalent families,
indexed by regular cardinals, and that n-topoi have univalent families classifying

(

n
-
2

)

${(n-2)}$

-truncated maps.
We show that univalent families are preserved (and detected) by right adjoints to locally cartesian localizations, and use this to exhibit certain canonical univalent families in

∞

$\infty$

-quasitopoi (certain

∞

${\infty}$

-categories of “separated presheaves”, introduced here).
We also exhibit some more exotic examples of univalent families, illustrating that a univalent family in an n-topos need not be

(

n
-
2

)

${(n-2)}$

-truncated, as well as some univalent families in the Morel–Voevodsky

∞

${\infty}$

-category of motivic spaces, an instance of a locally cartesian closed

∞

${\infty}$

-category which is not an n-topos for any

0
≤
n
≤
∞

${0\leq n\leq\infty}$

.
Lastly, we show that any presentable locally cartesian closed

∞

${\infty}$

-category is modeled by a combinatorial type-theoretic model category, and conversely that the

∞

${\infty}$

-category underlying a combinatorial type-theoretic model category is presentable and locally cartesian closed.
Under this correspondence, univalent families in presentable locally cartesian closed

∞

${\infty}$

-categories correspond to univalent fibrations in combinatorial type-theoretic model categories.
Evaluation of heating uniformity in radio frequency heating systems using carrot and radish
Authors: Kong Ling , Zhang Min , Wang Yuchuan , Adhikari Benu , Yang Zaixing 
Published: November 2016

Abstract
Lack of heating uniformity is a major problem impeding the broader adaptation of radio frequency heaters in industrial applications. The overall aim of this study was to evaluate the uniformity of heating or temperature distribution within food samples (three different carrot and one radish rectangles) placed vertically and horizontally within a radio frequency heating cavity. The intensity of the electric field in radio frequency was found to be symmetrical. The temperatures at the vertically top positions were lower than the vertically bottom positions at the equidistance from the vertical center with the highest was at the vertically central position. The rate of temperature rise at all the positions were higher in taller (higher mass) than the shorter (lower mass) rectangles of carrots. The temperatures at the corners and edges were lower than at the cross sectionally central positions at all the heights tested in both carrots and radishes. The rate of temperature rise at all the vertical positions was higher in radish rectangles than in the carrot rectangles of the same dimensions. The similarity of temperature distribution in carrot and radish rectangles suggested that the heating patterns and uniformity in carrots and radishes in RF heating were almost the same.
Soil porosity distribution representative elementary area analyzed through gamma-ray computed tomography
Authors: Ferreira Talita Rosas , Pires Luiz Fernando 
Published: November 2016

Abstract
This study aims to use γ-ray computed tomography images to define the representative elementary area of the soil porosity distribution. Different textured soils from Southeast Brazil and different schemes of areas were analyzed. The image acquisition was performed in 2006 using a first generation γ-ray computed tomography system equipped with 241Am radioactive source. Consecutive increasing areas located at the center (scheme 1), the inferior (scheme 2) and superior (scheme 3) borders of the sample computed tomography image, with size areas ranging from 1.2 to 678.8 mm², were selected. The full width at a half maximum parameter was used to describe the samples soil porosity distribution and mathematical analysis concepts were adopted to define the representative elementary area. The representative elementary areas found for the sandy soil (Geric Ferralsol) and clayey soils (Rhodic Ferralsol and Eutric Nitosol) were respectively: 514.3, 514.3 and 555.4 mm² (scheme 1); 279.5, 393.3 and 457.4 mm² (scheme 2); and 457.4, 457.4 and 457.4 mm² (scheme 3). The results confirmed that the representative elementary area were influenced by the soil texture and management. Different schemes were noticed to provide different representative elementary areas for the same soil, which suggests that this procedure was efficient to detect the heterogeneity inside the soil samples.
Quantification of hysteresis effects on a soil subjected to drying and wetting cycles
Authors: Rafraf Samia , Guellouz Lamia , Guiras Houda , Bouhlila Rachida 
Published: November 2016

Abstract
A quantitative description of soil hysteretic response during drying-wetting cycles is required to improve prediction of the soil water retention model. The objective of the study is to quantify the degree of hysteresis, which is helpful to evaluate the precision of soil water flow calculation. A new procedure to quantify the degree of hysteresis is presented. The Arya-Paris model allows assessment of hysteresis effects from initial drying curves, dynamic contact angles, degree of hysteresis value, and maximum difference value between drying and subsequent wetting curves. The experimental results show that the degree of hysteresis varies with the particle size, bulk density, void ratio, initial water content, and contact angle of the soil. The new findings can be very useful in modelling soil water flows.