bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy Between AJSM Author-Reported Disclosures and the Centers for Medicare and Medicaid Services Open Payments Database
Authors: Boddapati Venkat , Fu Michael C. , Nwachukwu Benedict U. , Ranawat Anil S. , Zhen Wilson Y. , Dines Joshua S. 
Published: January 2018

Background: Inaccurate disclosures of physician and industry relationships in scientific reporting may create an asymmetry of information by hiding potential biases. The accuracy of conflict of interest disclosure in sports medicine research is unknown. Purpose: To compare author financial disclosures in published articles in 2016 in the American Journal of Sports Medicine ( AJSM) with the Centers for Medicare and Medicaid Services’ Open Payments Database (OPD) to determine the percentage of payments values and percentage of eligible authors with discrepancies. Study Design: Cross-sectional study; no level of evidence (nonclinical). Methods: All articles published in 2016 in AJSM were screened to identify eligible authors. On the basis of OPD reporting, physician authors affiliated with a US institution were included. Stated disclosures in AJSM publications for these authors were identified and compared with industry-reported payments on OPD. Results: A total of 434 authors were included in this study. Mean and median total payments per author per year were $76,941 and $1692, respectively. The most commonly received payment was for food and beverage (81.3% of authors), followed by travel and lodging (45.4%) and consulting (31.8%). Authors with higher total payments were less likely to be discrepant in their reporting—notably, authors earning >$500,000 had 16.1% of payment values with discrepancy, as opposed to 85.3% for those earning <$10,000 ( P < .001). First authors had a lower percentage of payment values with discrepancy (13.8%) versus middle authors (31.9%, P = .001). Finally, men had a lower percentage of payment values with discrepancy (418 authors, 22.3% of payment values with discrepancy) as compared with women (16 authors, 95.3%; P < .001). Regarding industry payments specifically requested on the AJSM disclosure form for authors (royalties, consulting, research payments, and ownership and investments), only 25.3% of authors had a discrepancy in these payment categories in aggregate. Conclusion: Discrepancies exist between disclosures reported by authors publishing in AJSM and what is reported in the OPD. Authors receiving lower total payments, middle authors, and women are more likely to have disclosure discrepancies. Additionally, industry research funding support and ownership interest are most likely to go unreported. However, this study did not assess whether authors with industry payments preferentially published studies pertaining to products from companies from which they received funding. As national registries such as the OPD are increasingly utilized, physicians may benefit from referencing such databases before submitting conflict of interest disclosures.
Medium-term follow-up of 149 mobile-bearing total knee arthroplasties and evaluation of prognostic factors influencing outcomes
Authors: Rosso Federica , Cottino Umberto , Olivero Matteo , Bonasia Davide Edoardo , Bruzzone Matteo , Rossi Roberto 
Published: January 2018

Objective: To evaluate the medium-term outcomes of a posterior-stabilized mobile-bearing total knee arthroplasty (PS-MB-TKA) and the role of different prognostic factors. Methods: Patients indicated for a primary cemented PS-MB-TKA between 2002 and 2010 were included and prospectively evaluated using the Knee Society Scoring System (KSS) and the Hospital for Special Surgery (HSS) knee scores. The Knee Society Roentgenographic Evaluation form was used for the radiological evaluation. Different variables were collected and divided into patient- and surgery-related. Logistic regression was used to analyze the correlation between these variables and implants outcomes and survivorship. Results: In total, 149 cases were included (67.8% female, average age 70.4 years, SD ±9.4). The patella was resurfaced in 12.1% of the cases. All the implants were cemented. The average follow-up was 87.3 months (SD ±21.2). Postoperatively, there was a statistically significant improvement in all the scores. The cumulative survival was 96.2% (SD ±0.02%). At the regression analysis, female gender was associated to worse satisfaction KSS (OR = 0.26), functional KSS (OR = 0.22), and HSS (OR = 0.37) scores. Patellar resurfacing and subsequent contralateral procedures were associated to better functional KSS score (OR = 4.13, OR = 2.21), as well as varus preoperative alignment (OR = 2.12). On contrary, valgus preoperative alignment was associated to worse objective KSS score (OR = 0.23). No variables were correlated to failure or presence of radiolucent lines. Conclusion: Good medium-term outcomes were obtained using PS-MB-TKA, with a cumulative survivorship of 96.5%. Female gender and valgus preoperative alignment were associated to worse objective and subjective outcomes. Conversely, patellar replacement, subsequent contralateral TKA, and varus preoperative alignment were associated to better functional outcomes.
Awareness of middle sacral artery pathway: A cadaveric study of the presacral area
Authors: Singhatanadgige Weerasak , Kang Daniel G , Wiranuwat Dol , Tanavalee Chotetawan , Yingsakmongkol Wicharn , Limthongkul Worawat 
Published: January 2018

Purpose: To assess the anatomic path of the middle sacral artery (MSA) at the presacral area and its relationship to the spinal midline during an axial lumbar interbody fusion (AxiaLif) approach. Methods: Fifty human cadavers (25 males, 25 females) were used in this study. A transabdominal approach was used to expose the anterior aspect of the L5/S1 intervertebral disc and the presacral space. We measured the size and distance from the spinal midline at the following positions: (a) middle of the L5/S1 disc level, (b) 1 cm below the sacral promontory (SP), and (c) 2 cm below the SP. Each parameter was measured three times by two observers, and the mean value analyzed. Results: The MSA was present and originated from the left common iliac artery in all cadavers with a mean width of 2.14 mm. The position of the MSA in relation to the midline was most commonly on the left side (LS, 56%) followed by the right side (RS, 34%) and midline (ML, 10%). In the LS group, the distance from the midline is relatively constant in the three measured positions with a mean value of (a) 1.78 mm (range, 0–8.17 mm), (b) 2.08 mm (range, 0–7.10 mm), and (c) 2.06 mm (range, 0–9.76 mm). In the RS group, the distance from the midline increased from cephalad to caudad, with a mean value of (a) 1.44 mm (range, 0–9.64 mm), (b) 2.19 mm (range, 0–9.95 mm), and (c) 2.92 mm (range, 0–10.03 mm). Conclusions: Our study found the presacral anatomic path of the MSA was most commonly at the left of midline. In addition, the right-sided MSA variant had increasing distance from the midline along its anatomic path from cephalad to caudad. Our findings suggest an AxiaLif approach at the left of midline may place the MSA at greatest risk.
Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer: Long-Term Survival Analysis of the Randomized Phase III E3805 CHAARTED Trial
Authors: Kyriakopoulos Christos E. , Chen Yu-Hui , Carducci Michael A. , Liu Glenn , Jarrard David F. , Hahn Noah M. , Shevrin Daniel H. , Dreicer Robert , Hussain Maha , Eisenberger Mario , Kohli Manish , Plimack Elizabeth R. , Vogelzang Nicholas J. , Picus Joel , Cooney Matthew M. , Garcia Jorge A. , DiPaola Robert S. , Sweeney Christopher J. 
Published: January 2018

PurposeDocetaxel added to androgen-deprivation therapy (ADT) significantly increases the longevity of some patients with metastatic hormone-sensitive prostate cancer. Herein, we present the outcomes of the CHAARTED (Chemohormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer) trial with more mature follow-up and focus on tumor volume.Patients and MethodsIn this phase III study, 790 patients with metastatic hormone-sensitive prostate cancer were equally randomly assigned to receive either ADT in combination with docetaxel 75 mg/m2for up to six cycles or ADT alone. The primary end point of the study was overall survival (OS). Additional analyses of the prospectively defined low- and high-volume disease subgroups were performed. High-volume disease was defined as presence of visceral metastases and/or ≥ four bone metastases with at least one outside of the vertebral column and pelvis.ResultsAt a median follow-up of 53.7 months, the median OS was 57.6 months for the chemohormonal therapy arm versus 47.2 months for ADT alone (hazard ratio [HR], 0.72; 95% CI, 0.59 to 0.89; P = .0018). For patients with high-volume disease (n = 513), the median OS was 51.2 months with chemohormonal therapy versus 34.4 months with ADT alone (HR, 0.63; 95% CI, 0.50 to 0.79; P < .001). For those with low-volume disease (n = 277), no OS benefit was observed (HR, 1.04; 95% CI, 0.70 to 1.55; P = .86).ConclusionThe clinical benefit from chemohormonal therapy in prolonging OS was confirmed for patients with high-volume disease; however, for patients with low-volume disease, no OS benefit was discerned.
Image once, print thrice? Three-dimensional printing of replacement parts
Authors: Rankin Timothy M , Wormer Blair A , Miller John D , Giovinco Nicholas A , Al Kassis Salam , Armstrong David G 
Published: January 2018

Objective:
The last 20 years has seen an exponential increase in 3D printing as it pertains to the medical industry and more specifically surgery. Previous reviews in this domain have chosen to focus on applications within a specific field. To our knowledge, none have evaluated the broad applications of patient-specific or digital imaging and communications in medicine (DICOM) derived applications of this technology.

Methods:
We searched PUBMED and CINAHL from April 2012 to April 2017.

Results:
261 studies fulfilled the inclusion criteria. Proportions of articles reviewed: DICOM (5%), CT (38%), MRI (20%), Ultrasonography (28%), and Bio-printing (9%).

Conclusion:
There is level IV evidence to support the use of 3D printing for education, pre-operative planning, simulation and implantation. In order to make this technology widely applicable, it will require automation of DICOM to standard tessellation language to implant.

Advances in knowledge:
Recent lapses in intellectual property and greater familiarity with rapid prototyping in medicine has set the stage for the next generation of custom implants, simulators and autografts. Radiologists may be able to help establish reimbursable procedural terminology.
A responsabilidade dos empresários
Authors: Wilner Adriana , Santos Aline Lilian dos 
Published: January 2018

Você consegue chegar em casa depois do trabalho e contar para a sua família tudo o que fez durante o dia? Esse é o termômetro de responsabilidade social que Oded Grajew indica a seus colegas. Ex-empresário e fundador de ONGs como Fundação Abrinq [Associação Brasileira dos Fabricantes de Brinquedos] pelos Direitos da Criança e do Adolescente, Fórum Social Mundial, Instituto Ethos, Rede Nossa São Paulo e Programa Cidades Sustentáveis, Grajew tem sido ativista em diversas causas, entre elas, o combate à corrupção nas empresas.Nascido na Palestina, em 1944, quatro anos antes da fundação do Estado de Israel, Grajew veio para o Brasil aos 12 anos, após rápida passagem da família por Paris, na França. O pai, que representava empresas de relógios, morreu três anos depois e os planos da família de se mudar para Madri, na Espanha, tiveram que ser cancelados. Para continuar estudando, Grajew foi vendedor de livros porta a porta, de cotas de empreendimentos, entre outros. Assim, conseguiu cursar Engenharia Elétrica na Escola Politécnica da Universidade de São Paulo (Poli-USP).Depois de trabalhar em organizações e bancos, fundou com colegas da faculdade a empresa de brinquedos Grow – formada pelas iniciais dos nomes dos sócios Geraldo, Roberto, Oded e Waldir. Foi convidado para assumir o Sindicato das Empresas de Brinquedos e Instrumentos Musicais do Estado de São Paulo e, a partir de então, envolveu-se em diversas iniciativas associativas.Em entrevista exclusiva à GV-executivo, Grajew fala dos desafios para combater a corrupção, das dificuldades para aprovar normas e leis de responsabilidade social e aponta perspectivas de renovação após os recentes escândalos envolvendo empresas e políticos.
Falta experiência para exportar
Authors: Pignanelli Alexandre , Santos Juliana Bonomi , Morais Dafne Oliveira Carlos de 
Published: January 2018

Políticas nacionais de apoio às exportações têm focado nas micro e pequenas empresas. No entanto, mais do que tamanho, é o pouco know-how que impede as empresas (de todos os portes) de vender para outros países.
Avaliação da atividade moduladora e citotóxica do óleo essencial das folhas de Hyptis martiusii Benth
Authors: Sobreira Dantas Nóbrega de Figueirêdo Francisco Rodolpho , Bitu Primo Ana Jaqueline , Brito Monteiro Álefe , Relison Tintino Saulo , De Araújo Delmondes Gyllyandeson , Dos Santos Sales Valterlúcio , De Souza Rodrigues Cristina Kelly , Bezerra Felipe Cicero Francisco , Melo Coutinho Henrique Douglas , Kerntopf Marta Regina 
Published: January 2018

A espécie Hyptis martiusii Benth é popularmente conhecida como “cidreira do campo”. Possui várias atividades biológicas, dentre elas atividades antifúngica, antiin amatória e inseticida. O objetivo deste trabalho foi investigar a atividade moduladora do óleo essencial das folhas frescas de Hyptis martiusii em associação com diferentes antibióticos frente às bactérias Staphylococcus aureus, Escherichia coli e Pseudomonas aeruginosa, como também a atividade citotóxica da espécie. O estudo utilizou a cim (con- centração inibitória mínima) como forma de avaliação da modulação usando uma inoculação de 100 microlitros de cada estirpe bacteriana. Os ensaios de citotoxicidade foram realizados in vitro utilizando a cultura de linhagem de células do tecido conectivo de camundongo ( broblastos de mamíferos). A pesquisa demonstrou que o Óleo Essencial das folhas de Hyptis martiusii Benth —oehm— apresentou sinergismo apenas em associação com os antibióticos gentamicina e imipenem frente às bactérias Pseudomonas aeruginosa e Escherichia coli. No entanto, apresentou antagonismo em associação com amicacina, gentamicina e imipenem frente às três bactérias estudadas. Em junção com o cipro oxaci- no não apresentou resultados relevantes. Em relação à atividade citotóxica a concentração letal média (LC50) expôs um valor de 263,12 μg/ml. Por m, revelou-se que H. martiusii apresenta atividade citotóxica e baixa atividade sinérgica frente às bactérias avaliadas.
Multidisciplinary knowledge of local anaesthetic systemic toxicity in maternity care: A pilot study
Authors: Bowsher Gemma M , Deepak Sahil , Edwards Amy 
Published: January 2018

Background Although widely used in maternity care, the risks associated with local anaesthetic (LA) agents are commonly overlooked. The most serious avoidable risk associated with LA use is local anaesthetic systemic toxicity (LAST). Incidence in maternity settings is known to be underestimated due to under-recognition and under-reporting. LAST is a considerable problem, with potential financial and medico-legal as well as implications for patient safety. Methods A standardised, anonymised questionnaire was used to evaluate LAST awareness among staff of all disciplines. Awareness was examined across four domains: LA safe maximum doses, signs and symptoms of toxicity, immediate management, and the antidote type and location. Findings Poor LAST awareness was identified across all staff disciplines, with scope for substantial improvement with an interprofessional educational intervention. Only 17% were aware of any guidelines relating to LAST. Conclusion There is a need for greater focus on interdisciplinary education and the importance of shared responsibility in optimising patient safety.
Reviewing the effect of hyperemesis gravidarum on women's lives and mental health
Authors: Dean Caitlin , Bannigan Katrina , Marsden Jonathan 
Published: January 2018

Background Hyperemesis gravidarum is a condition that affects 1–1.5% of pregnant women, and is characterised by extreme levels of intractable nausea and vomiting. Aims To understand the association between hyperemesis gravidarum and psychological morbidity. Methods A qualitative literature review of the effects of nausea and vomiting in pregnancy and hyperemesis gravidarum was undertaken. An extensive search of multiple databases was undertaken and the results appraised and synthesised. Findings Four main themes and two subthemes emerged in relation to mental health effects. The main themes were: social isolation; unable to care for self and others or change of role; negative psychological effects (depression, anxiety, guilt and loss of self); and sense of dying, suicidal ideation or termination. The subthemes were loss of earnings or employment; and changes to family plans. Conclusion A shift towards an holistic biopsychosocial approach to care for hyperemesis gravidarum is required. Health professionals can help women by allowing them to express their feelings, and validating them. Where required, referral to the perinatal mental health team or a peer support system may be appropriate.
Comparison of Rhodotorula sp. and Bacillus megaterium in the removal of cadmium ions from liquid effluents
Authors: Roşca Mihaela , Hlihor Raluca-Maria , Cozma Petronela , Drăgoi Elena Niculina , Diaconu Mariana , Silva Bruna , Tavares Teresa , Gavrilescu Maria 
Published: January 2018

AbstractThis study compares the capacity ofRhodotorulasp. andBacillus megateriumfor Cd(II) removal considering the influence of operating parameters (pH, biosorbent dosage, contact time, temperature, initial metal concentration in solution). The highest Cd(II) uptake of 14.2 mg/g byRhodotorulasp. was exhibited at 30°C, when working at pH 6 and with 5 g/l biosorbent dosage, after 48 h of contact time. In these conditions, a removal efficiency of 85% was obtained. Similar outcomes were obtained forB. megaterium(15.1 mg/g, 90%) at 35°C, pH 4 and 3 g/l biosorbent dosage, considered as the optimum set of parameters, equilibrium being achieved for a contact time of 20 min. The possible interaction mechanisms between the biosorbents and Cd(II) were evaluated through point of zero charge (pHpzc), Fourier transform infrared (FTIR), spectroscopy and scanning electron microscopy coupled with energy dispersive X-ray microanalysis (SEM-EDX). Data were modeled using pseudo-first and pseudo-second order kinetic models and Langmuir and Freundlich isotherms models. Further studies considered a modeling approach based on linear regression with Durbin-Watson statistics, while the accuracy and precision of experiments were evaluated by ANOVA.
Update on mitochondria and muscle aging: all wrong roads lead to sarcopenia
Authors: Picca Anna , Calvani Riccardo , Bossola Maurizio , Allocca Elena , Menghi Amerigo , Pesce Vito , Lezza Angela Maria Serena , Bernabei Roberto , Landi Francesco , Marzetti Emanuele 
Published: January 2018

Abstract
Sarcopenia is a well-known geriatric syndrome that has been endorsed over the years as a biomarker allowing for the discrimination, at a clinical level, of biological from chronological age. Multiple candidate mechanisms have been linked to muscle degeneration during sarcopenia. Among them, there is wide consensus on the central role played by the loss of mitochondrial integrity in myocytes, secondary to dysfunctional quality control mechanisms. Indeed, mitochondria establish direct or indirect contacts with other cellular components (e.g. endoplasmic reticulum, peroxisomes, lysosomes/vacuoles) as well as the extracellular environment through the release of several biomolecules. The functional implications of these interactions in the context of muscle physiology and sarcopenia are not yet fully appreciated and represent a promising area of investigation. Here, we present an overview of recent findings concerning the interrelation between mitochondrial quality control processes, inflammation and the metabolic regulation of muscle mass in the pathogenesis of sarcopenia highlighting those pathways that may be exploited for developing preventive and therapeutic interventions against muscle aging.
Body, Language and Mediality
Authors: Toru Tani 
Published: January 2018

Abstract
Husserl attempted to found logics and language on intuition, and particularly perception. The relationship between logical language and intuition is therefore one of the fundamental themes of his phenomenology. Husserl regarded the two as sharing an isomorphic structure, and this article shows that this structure can be characterized as “mediality.” That is, the “meaning” of language appears by mediation of sound or script, while the “I” as person appears by mediation of the body. I will show furthermore that intuitions themselves appear through the mediation of language, and interpret this idea of mediality in terms of the Japanese language. Guided by Husserl’s notion of Sprachleib (linguistic living body), I will also attempt an analysis of the “bodily” function of Chinese script and onomatopeia as aspects of Sprachleib and show how the Sprachleib functions as a “cultural living body” that makes community possible.
Low Second-To-Fourth Digit Ratio Has High Explosive Power? A Prepubertal Study
Authors: Hsu Cheng-Chen , Fong Tsorng-Harn , Chang Hung-Ming , Su Borcherng , Chi Chung-Pu , Kan Nai-Wen , Hsu Mei-Chich 
Published: January 2018

Abstract
Hsu, CC, Fong, TH, Chang, HM, Su, B, Chi, CP, Kan, NW, and Hsu, MC. Low second-to-fourth digit ratio has high explosive power? A prepubertal study. J Strength Cond Res 32(7): 2091–2095, 2018—A recent study reported that lower limb explosive power had no correlation with the index finger: ring finger (2D:4D) ratio. However, many studies hypothesized that a lower 2D:4D ratio (reflecting a relative higher testosterone exposure) predicts higher physical fitness. The aim of this study was to replicate the study of explosive power and the 2D:4D ratio in a sample of Taiwanese children. A total of 541 Taiwanese prepubertal children (257 girls and 284 boys aged 9–10 years) participated in this study. This study analyzed the relationship between the 2D:4D ratio and explosive power. Explosive power of the lower limbs was assessed using the standing long jump (SLJ) test. The lengths of the second and fourth fingers of the right hand were measured to calculate the 2D:4D ratio. The SLJ length was correlated with the 2D:4D ratios (r = −0.144, p = 0.015) in boys. After controlling for age and the body mass index, this correlation remained significant (r = −0.134, p = 0.024). For girls, 2D:4D ratios were not significantly correlated with SLJ scores. These results indicate that the SLJ distance was negatively correlated with the 2D:4D ratio in boys, but not in girls. These findings might suggest that prenatal testosterone exposure is negatively correlated with the explosive power in men, but not in women.