bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular epidemiology of acute hemorrhagic conjunctivitis caused by coxsackie A type 24 variant in China, 2004–2014
Authors: Zhang Li , Zhao Na , Huang Xiaodan , Jin Xiuming , Geng Xingyi , Chan Ta-Chien , Liu Shelan 
Published: March 2017

AbstractTo understand control interventions, the molecular epidemiology of acute hemorrhagic conjunctivitis (AHC) was investigated from 2004 to 2014.A total of 613,485 AHC cases (annualized cases 55,771) with two deaths were included. Our findings showed that AHC was reported in all provinces, predominantly in Southern and Eastern China. The incidence rates were highest in 2007 (5.65/100,000) and 2010 (21.78/100,000) respectively. A clear seasonal pattern was identified with a peak from August to October. AHC cases occurred in all age groups; however, five to 14 years was the predominant group [23.06%, 133, 510/578,909]. The median age was 24 years (one month~97 years). The median duration from onset to diagnosis was 1.5 days, and there was no difference between the <15, 15~60 and >60-year-old patients [p = 0.0653]. The phylogenetic analysis of 100 nonstructural proteins (3C) and 84 structural proteins (VP1) revealed that AHC outbreaks were caused by Coxsackievirus A24 variant. Genotypes G4-c5a, G4-c5b, and G4-c3 co-circulated with both temporal and geographical overlaps. In conclusion, despite the overall steady decline in the number of AHC cases since the peak in 2010, it still remains a serious public health problem in Southern and Eastern China that targets on the school aged children under 15 years old.
Structural insights into the nucleotide base specificity of P2X receptors
Authors: Kasuya Go , Fujiwara Yuichiro , Tsukamoto Hisao , Morinaga Satoshi , Ryu Satoshi , Touhara Kazushige , Ishitani Ryuichiro , Furutani Yuji , Hattori Motoyuki , Nureki Osamu 
Published: March 2017

AbstractP2X receptors are trimeric ATP-gated cation channels involved in diverse physiological processes, ranging from muscle contraction to nociception. Despite the recent structure determination of the ATP-bound P2X receptors, the molecular mechanism of the nucleotide base specificity has remained elusive. Here, we present the crystal structure of zebrafish P2X4 in complex with a weak affinity agonist, CTP, together with structure-based electrophysiological and spectroscopic analyses. The CTP-bound structure revealed a hydrogen bond, between the cytosine base and the side chain of the basic residue in the agonist binding site, which mediates the weak but significant affinity for CTP. The cytosine base is further recognized by two main chain atoms, as in the ATP-bound structure, but their bond lengths seem to be extended in the CTP-bound structure, also possibly contributing to the weaker affinity for CTP over ATP. This work provides the structural insights for the nucleotide base specificity of P2X receptors.
Hunting promotes spatial reorganization and sexually selected infanticide
Authors: Leclerc M. , Frank S. C. , Zedrosser A. , Swenson J. E. , Pelletier F. 
Published: March 2017

AbstractHarvest can affect the ecology and evolution of wild species. The removal of key individuals, such as matriarchs or dominant males, can disrupt social structure and exacerbate the impact of hunting on population growth. We do not know, however, how and when the spatiotemporal reorganization takes place after removal and if such changes can be the mechanism that explain a decrease in population growth. Detailed behavioral information from individually monitored brown bears, in a population where hunting increases sexually selected infanticide, revealed that adult males increased their use of home ranges of hunter-killed neighbors in the second year after their death. Use of a hunter-killed male’s home range was influenced by the survivor’s as well as the hunter-killed male’s age, population density, and hunting intensity. Our results emphasize that hunting can have long-term indirect effects which can affect population viability.
Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing
Authors: Howell Kristen , Chien Chun , Bell Rebecca , Laudier Damien , Tufa Sara F. , Keene Douglas R. , Andarawis-Puri Nelly , Huang Alice H. 
Published: March 2017

AbstractTo date, the cell and molecular mechanisms regulating tendon healing are poorly understood. Here, we establish a novel model of tendon regeneration using neonatal mice and show that neonates heal via formation of a ‘neo-tendon’ that differentiates along the tendon specific lineage with functional restoration of gait and mechanical properties. In contrast, adults heal via fibrovascular scar, aberrant differentiation toward cartilage and bone, with persistently impaired function. Lineage tracing identified intrinsic recruitment of Scx-lineage cells as a key cellular mechanism of neonatal healing that is absent in adults. Instead, adult Scx-lineage tenocytes are not recruited into the defect but transdifferentiate into ectopic cartilage; in the absence of tenogenic cells, extrinsic αSMA-expressing cells persist to form a permanent scar. Collectively, these results establish an exciting model of tendon regeneration and uncover a novel cellular mechanism underlying regenerative vs non-regenerative tendon healing.
Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1
Authors: van Haren Matthijs J. , Marechal Nils , Troffer-Charlier Nathalie , Cianciulli Agostino , Sbardella Gianluca , Cavarelli Jean , Martin Nathaniel I. 
Published: March 2017

Significance
The posttranslational methylation of arginine is a widespread epigenetic modification catalyzed by the family of protein arginine methyltransferases (PRMTs). Dysregulation of PRMT expression is implicated in the pathogenesis of many diseases including human cancers. An atomic-scale understanding of the PRMT catalytic mechanism is crucial for both fundamental biological and pharmacological applications. Despite intense efforts, crystal structures of PRMT complexes with long peptides and full-length substrates have not been solved because of their inherent instability. To address this issue, we describe peptide-based transition state mimics that form stable complexes with the PRMT enzyme coactivator associated arginine methyltransferase 1 resulting in high-resolution cocrystal structures. Our findings provide an exciting approach to understanding PRMT substrate recognition and the regulation of arginine methylation.
Localized hepatic lobular regeneration by central-vein–associated lineage-restricted progenitors
Authors: Tsai Jonathan M. , Koh Pang Wei , Stefanska Ania , Xing Liujing , Walmsley Graham G. , Poux Nicolas , Weissman Irving L. , Rinkevich Yuval 
Published: March 2017

Significance
After partial hepatectomy, the adult mammalian liver regenerates through the mobilization of all hepatocytes characterized by a few cycles of cell division and subsequent hypertrophy with loss of global architecture. We have discovered a form of regeneration in the neonatal mouse liver, specific to the first week of life, where we observe numerous rounds of cell division and reconstitution of lobe architecture much like in amphibian limbs. This regenerative process is characterized by clonal expansion of select hepatocyte-specific stem or progenitors that localize to the central vein and is one of the first characterized instances of true mammalian regeneration.
Introduction
Authors: Miller Kiri 
Published: March 2017

Abstract
The introduction provides an overview of dance games and the five major thematic areas explored in the book: surveillance, control, and consent; performativity and embodied difference; kinesthetic listening; the virtual transmission of embodied practice; and choreographic labor. Each theme offers different insights into how dance games function as intimate media. This chapter includes a brief history of dance games and the music/rhythm games that preceded them, and a comparative account of the affordances of the Nintendo Wii and Xbox Kinect as motion-sensing interfaces. It lays out the research methodologies employed for this project, including digital ethnography and “do-it-yourself/do-it-again” ethnography (DIY/DIA), and situates the book with respect to related scholarship on performance, digital media, participatory culture, and popular music.
I See You, I See You!
Authors: Miller Kiri 
Published: March 2017

Abstract
This chapter investigates the private/public tensions built into digital dance gameplay. Dance games offer private dance lessons using surveillance technologies. This core contradiction makes the games function as engines of humor, shame, pride, suspicion, trust, and intimacy as players perform game choreography in a range of social contexts. The chapter addresses themes of control, consent, spectatorship, and social risk by analyzing marketing strategies, industry reviews, and early player reception of the Just Dance and Dance Central games. It offers a technical overview of the Wii and Kinect systems, shows how players test and evaluate each system’s perceptual capacities, and introduces the concepts of “kinesthetic vision” and “virtual proprioception.” Dance gameplay brings together the performance conventions and technical affordances of videogames, social media platforms, and user-facing cameras integrated into consumer media devices, yielding complex dynamics of seeing-and-being-seen.
Dancing Difference/Gaming Gender
Authors: Miller Kiri 
Published: March 2017

Abstract
This chapter shows how dance games invite players to engage with embodied difference. The games are built around popular music and dance styles that function as signs of gender, sexuality, race, ethnicity, and class; their screen dancers also bear marks of intersectional identities, which may or may not match those of the musical and choreographic repertoires that they perform. Dance games follow in the footsteps of minstrelsy and drag traditions by staging song-and-dance variety shows that center on racialized and gendered performances. The games afford performative possibilities for both reinforcing and destabilizing essentialist identity categories. The chapter explains how constructivist gender theory informed the development process for the Dance Central series, and explores what happens when designers enlist players in putting theory into practice.
Measuring the Spread of Modern Manufacturing to the Poor Periphery
Authors: Bénétrix Agustín S. , O’Rourke Kevin Hjortshøj , Williamson Jeffrey Gale 
Published: March 2017

Abstract
This chapter documents industrial output growth around the poor periphery (Latin America, the European periphery, the Middle East and North Africa, Asia, and Sub-Saharan Africa) between 1870 and 2007. We find that although the roots of rapid peripheral industrialization stretch into the late nineteenth century, the high point of peripheral industrialization was the 1950–73 period, which saw widespread import-substituting industrialization (ISI). This ISI period was also the high point of unconditional industrial catching-up, defined as the tendency of less industrialized countries to post higher per capita manufacturing growth rates than more industrialized countries. However, this post-Second World War ISI episode was preceded by significant industrial catching-up, thus defined, in the 1920s and 1930s, as well as the 1940s in Latin America. And the catching-up in those inter-war decades was not simply because of a manufacturing collapse of the leaders during the Great Depression.
State and Market in Russian Industrialization, 1870–2010
Authors: Markevich Andrei , Nafziger Steven 
Published: March 2017

Abstract
This chapter surveys the history of Russian industrialization. It begins by exploring its roots in the nineteenth century; continues with an examination of the Soviet period; and concludes with a survey of developments over the post-Soviet decades. Our focus is on the dual role that markets and state policies have played in fostering, accelerating, and hindering Russian industrial development during all three periods. We provide a unified empirical picture of the industrial sector for the entire period, highlight the interactions of Russian and Soviet industry with the global economy, and emphasize the importance of the Russian case for understanding the possibilities of late industrialization.
How Peripheral was the Periphery?
Authors: Klein Alexander , Schulze Max-Stephan , Vonyó Tamás 
Published: March 2017

Abstract
This chapter explores the timing, pace, and spatial diffusion of modern industry in the former Habsburg Empire and its successor states. The regions adjacent to Western Europe, Alpine Austria, and the Czech lands shifted from proto-industrial to modern manufacturing first, followed by the western parts of Hungary. Though well advanced in the western and northwestern regions, industry diffused only slowly to the east and southeast, with profound implications for East Central European economies throughout the twentieth century. It is argued that this part of Europe stepped into the industrial age before most of the global periphery; that economic growth was mainly driven by industry from the late nineteenth century to the collapse of state socialism; and that the contribution of industry to aggregate value added was associated with a growing share of ‘modern’ manufacturing in industrial production. However, post-war interventionist policies failed to erase relative backwardness in East Central Europe.
Industrialization in Egypt and Turkey, 1870–2010
Authors: Karakoç Ulaş , Pamuk Şevket , Panza Laura 
Published: March 2017

Abstract
This chapter examines the industrial performance of Egypt and Turkey during four periods: 1870 to the First World War under open economy conditions; the inter-war era when industrialization began with the help of protection; the decades after the Second World War when the import-substituting industrialization model was adopted and rates of industrialization peaked; and trade liberalization since 1980. Per capita incomes were similar in Egypt and Turkey around 1870 but were 150 per cent higher in Turkey than in Egypt in 2010. The chapter identifies several factors which explain this divergence: land abundance in Turkey and its scarcity in Egypt; initial social structure and related political economy forces; government intervention; and the quality of related institutions. In terms of human capital investment, Turkey and Egypt lagged behind countries in Latin America and East Asia, which made it difficult for manufacturing to move towards sectors with higher technology and value added.
Industrialization in China
Authors: Brandt Loren , Ma Debin , Rawski Thomas G. 
Published: March 2017

Abstract
This chapter views industrial growth in China over the last 150 years as an ongoing process through which firms acquired and deepened manufacturing capabilities. Two factors have been consistently important: openness to the international economy and domestic market liberalization. For a latecomer like China, modern industry initially has greatest success in more labour-intensive products requiring only modest capabilities. Gradual upgrading entails the shift into more skilled-labour and capital-intensive products and processes. Our construction and review of long-term data shows that (i) China’s industrial growth rate consistently exceeded that of Japan, India, and Russia/USSR throughout most of the twentieth century; (ii) China’s shift from textiles and other light industry toward defence-related industries began before rather than after 1949, as did the geographic spread of industry; and (iii) the state sector has consistently been a brake on industrial upgrading, highlighting the significance of current reform initiatives in determining China’s future industrial path.
From Commodity Booms to Economic Miracles
Authors: Bassino Jean-Pascal , Williamson Jeffrey Gale 
Published: March 2017

Abstract
Indonesia, Malaysia, and Thailand emerged unexpectedly in the 1960s and 1970s as fast-growing, labour-intensive manufacturing countries. Their industrial growth rates closely matched those of Japan, South Korea, and Taiwan for more than two decades. This sudden export-led ‘miracle’ took place in the context of political instability and ethnic tensions, after more than two decades of modest success with post-independence, import-substituting industrialization strategies there and in other Southeast Asian nations. Cambodia and Vietnam joined the export-led manufacturing club in the 1990s, followed by Myanmar in the 2000s. The Philippines was the only Southeast Asian nation to miss the late twentieth-century ‘miracle’. Southeast Asia experienced some impressive GDP per capita growth between 1870 and 1940, but, outside of the Philippines, manufacturing stagnated and modern enterprises were confined to commodity export processing. The chapter analyses the region’s dismal industrial performance before the 1960s, and why manufacturing grew so fast in the following decades.
Industrialization and Growth in Peru and Mexico, 1870–2010
Authors: Gómez-Galvarriato Aurora , Colín Graciela Márquez 
Published: March 2017

Abstract
The industrialization experiences of Mexico and Peru differed because of their different market sizes and location. Mexico’s larger market and border with the US gave it greater opportunities for industrialization. Peru’s development is closer to that of the classic late-nineteenth-century commodity exporter and followed the primary-goods-exports model for longer. Until the 1980s both countries had relatively high wages, inhibiting the development of labour-intensive manufactured exports, but they lacked the education and skill levels to produce more technologically sophisticated manufacturing goods. Contrary to common belief, commodity export-led growth supported industrial growth as long as exports were diversified and the government pursued sound fiscal and monetary policies. Import substitution policies fostered manufacturing growth when coupled with macroeconomic stability and policies promoting domestic and foreign investment. After economic liberalization in recent decades, Peru returned to relying on commodity exports, while Mexico developed assembly export manufacturing, with very low levels of domestic value added.
Patterns of Manufacturing Growth in Sub-Saharan Africa
Authors: Austin Gareth , Frankema Ewout , Jerven Morten 
Published: March 2017

Abstract
This chapter reviews the ‘long twentieth-century’ development of ‘modern’ manufacturing in Sub-Saharan Africa from colonization to the present. It argues that classifying Africa generically as a ‘late industrializer’ is inaccurate. To understand the distinctively African pattern of manufacturing growth, the discussion focuses on the dynamic interplay between the region’s specific endowment structures, global economic relationships, and government policies. It concludes that Sub-Saharan Africa is best characterized as a case of interrupted industrial growth instead of sustained convergence on world industrial leaders. This is partly because, until very recently, factor endowments made it very costly for states to pursue industrialization; and partly because successive rulers, colonial and post-colonial, have rarely had both the capacity to adopt and the dedication to sustain policies that modified the region’s existing comparative advantage in primary production, by using their fiscal and regulatory powers effectively to promote industrialization.
Symmetry-protected topological phases in one-dimensional systems
Authors: Pollmann Frank 
Published: March 2017

Abstract
Classifying and understanding phases of matter is an important task in condensed matter physics. The class of ‘conventional’ symmetry-broken phases is well understood in terms of Landau’s theory. A paradigmatic example is the Z2-symmetric Ising model with symmetric (paramagnetic) and symmetry-broken (ferromagnet) phases, which can be distinguished by measuring the magnetization as a local order parameter. Topological phases of matter, however, are less understood and no complete classification is known. These lecture notes discuss schemes that provide an understanding and characterization of certain topological phases of matter in models with local Hamiltonians. The main focus is on symmetry-protected topological (SPT) phases in one-dimensional bosonic systems. On the basis of the entanglement properties of such systems, a motivation is given for the matrix product state (MPS) representation of ground states. Using the MPS framework, it is demonstrated how SPT phases can be classified using projective representations of the symmetries.
Ethnic Disadvantage
Authors: Singhal Saurabh , Beck Ulrik 
Published: March 2017

Abstract
This chapter investigates the ethnic disadvantage in rural Viet Nam, focusing on the magnitude of the majority–minority gap and constraints on ethnic minority households that contribute to the gap. The chapter documents large improvements in living standards both for the Kinh majority as well as for the ethnic minorities. However, a significant difference between the Kinh households and the rest persists. Examining the sources of income shows that non-Kinh households are less likely to diversify into high-yielding non-farm activities. Non-Kinh households have lower quality agricultural land, lower rates of ownership certificates, face more problems in producing and selling their agricultural products, and have worse access to credit. However, the locational disadvantage of the non-Kinh households has substantially declined over time. The data allows examination of intra-minority dynamics—differences are found among the various non-Kinh minorities along spatial, ethnic, and linguistic lines.
Patient Response to an Integrated Orthotic and Rehabilitation Initiative for Traumatic Injuries: The PRIORITI-MTF Study
Authors: Hsu Joseph R. , Owens Johnny G. , DeSanto Jennifer , Fergason John R. , Kuhn Kevin M. , Potter Benjamin K. , Stinner Daniel J. , Sheu Robert G. , Waggoner Sandra L. , Wilken Jason M. , Huang Yanjie , Scharfstein Daniel O. , MacKenzie Ellen J. ,   METRC
Published: March 2017

Summary:
Although limb salvage is now possible for many high-energy open fractures and crush injuries to the distal tibia, ankle, hindfoot, and midfoot, orthotic options are limited. The Intrepid Dynamic Exoskeletal Orthosis (IDEO) is a custom, energy-storing carbon fiber orthosis developed for trauma patients undergoing limb salvage. The IDEO differs from other orthoses in that it allows patients with ankle weakness to have more normal ankle biomechanics and increased ankle power. This article describes the design of a study to evaluate the effectiveness of the IDEO when delivered together with a high-intensity, sports medicine–based approach to rehabilitation. It builds on earlier studies by testing the program at military treatment facilities beyond the Brooke Army Medical Center and the Center for the Intrepid where the device was developed. The PRIORITI-MTF study is a multicenter before-after program evaluation where participants at least 1 year out from a traumatic lower extremity injury serve as their own controls. Participants are evaluated before receiving the IDEO, immediately after 4 weeks of physical therapy with the IDEO and at 6 and 12 months after the completion of physical therapy. Primary outcomes include functional performance, measured using well-validated assessments of speed, agility, power, and postural stability and self-reported functioning using the Short Musculoskeletal Function Assessment (SMFA) and the Veterans Health Survey (VR-12). Secondary outcomes include pain, depression, posttraumatic stress, and satisfaction with the IDEO.