bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Kid in Town? Active Inclusion Elements in European Minimum Income Schemes
Authors: Marchal Sarah , van Mechelen Natascha 
Published: November 2015

AbstractThis article assesses the current variation in activation strategies directed towards able‐bodied persons of working age relying on a minimum income guarantee in 19 EU member states. First, we argue that the active inclusion notion developed by the European Commission in its Recommendation on the active inclusion of persons excluded from the labour market provides a useful tool to categorize current activation strategies towards minimum income protection (MIP) recipients. Consequently, we assess the empirical viability of active inclusion strategies in a fuzzy set ideal type analysis of purpose‐collected institutional data. We find that there are only few countries where the activation discourse has remained a dead letter. Most countries implement policy measures that aim to discourage benefit dependency among MIP recipients. Nevertheless, behind the realities of activation strategies towards MIP recipients seldom lies the notion of active inclusion as defined by the European Commission. Particularly, many countries focus predominantly on incentives to increase labour market participation rates of MIP recipients, rather than enabling measures.
The impact of fertilizer management on the oxidation status of terrestrial organic matter
Authors: Worrall F. , Clay G. D. , Macdonald A. 
Published: November 2015

AbstractThe oxidative ratio (the ratio of moles of O2 produced per mole CO2 sequestered – OR) of the organic matter in the terrestrial biosphere governs the ability of the terrestrial biosphere to uptake CO2. The value of OR is known to vary between environments, but it would also be expected to vary with management. This study measured the OR of plant and soil samples from the long‐term grassland plots on the Park Grass experiment at Rothamsted (SE England). The selected plots included those with different fertilizer inputs, including farmyard manure or inorganic fertilizers and an unfertilized control, each with and without lime. The measurements show that: (i) Use of inorganic fertilizer caused the OR of soil organic matter to increase. (ii) Farmyard manure (FYM) caused OR of the soil to increase but that of the vegetation decreased. (iii) Liming had the effect of decreasing OR and counteracting effects of fertilizer. (iv) The OR of the ecosystem increased with FYM application but decreased with inorganic fertilizer application. The global pattern in the use of organic amendments and inorganic fertilizers suggests that the likely impact of the predicted increase in global inorganic fertilizer use will result in a net decrease in the OR of the organic matter of the terrestrial biosphere, and an increase in its ability to act as a carbon sink. Corresponding increases in global FYM use and its impact upon global OR are unlikely to be large enough to counteract this effect.
The ability of the DGT soil phosphorus test to predict pasture response in Australian pasture soils – a preliminary assessment
Authors: Burkitt L. L. , Mason S. D. , Dougherty W. J. , Sale P. W. G. 
Published: November 2015

AbstractDiffusive gradients in thin‐films (DGT) technology provides an alternative assessment of available phosphorus (P) for a range of crops, suggesting a preliminary examination of the performance of the new DGT‐P test, compared to existing bicarbonate extractable Olsen and Colwell P tests, for pastures is justified. This study utilized historic data from the Australian National Reactive Phosphate Rock (NRPR) study (1992–1994) that included 25 experimental sites representing a wide range of soil types and climates used for pasture production. Stored (~19 yr) soil samples were analysed for DGT‐P, Olsen P and a single point P buffering index (PBI) and re‐analysed for Colwell P. Results showed the traditional bicarbonate extractable Colwell (r2 = 0.45, P < 0.001) and Olsen P (r2 = 0.27, P < 0.001) methods predicted relative pasture P response more accurately, compared to the novel DGT‐P test (r2 = 0.09, P = 0.03) when all 3 yr of data were examined. We hypothesize that the harsher bicarbonate extraction used for the Olsen and Colwell methods more accurately reflects the ability of perennial pasture roots to access less labile forms of P, in contrast to the DGT‐P test, which does not change the soil pH or dilute the soil and appears unable to fully account for a plants ability to solubilize P. Further studies are needed to compare the capacity of DGT‐P to measure P availability in perennial pasture systems and to better understand the soil chemical differences between pasture and cropping systems.
Re‐evolution of a morphological precursor of crypsis investment in the newly revised horned praying mantises (Insecta, Mantodea, Vatinae)
Authors: SVENSON GAVIN J. , MEDELLIN CAROLINA , SARMIENTO CARLOS E. 
Published: November 2015

AbstractThe Neotropical praying mantis tribe Vatini Stål is revised using total evidence phylogenetic analysis based on molecular and coded morphological data. The subfamily Vatinae is redefined to only include Neotropical taxa with the removal of distantly related African and Asian lineages. A new tribe is erected under Vatinae (Heterovatini trib.n.) for two unique genera with historically unstable taxonomic placement (Heterovates Saussure and Chopardiella Giglio‐Tos). Phylogenetic results and morphology support the synonymy of three genera (Lobovates Deeleman‐Reinhold, Phyllovates Kirby, and Hagiotata Saussure & Zehntner) and the validity of Chopardiella Giglio‐Tos, Heterovates Saussure, Callivates Roy, Pseudovates Saussure, Vates Burmeister, and Zoolea Audinet Serville. A new genus (Alangularis gen.n.) is created for a former species of Vates with unique morphology and separate phylogenetic placement. All genera are redescribed based on external morphology and the male genital complex. A key to genera for Vatinae is provided with dorsal habitus images of representatives for each genus. A distinct pattern of correlated evolution of morphological characters linked to crypsis was uncovered. Cuticular leg lobes within single leg segments are evolving as sets, and serially homologous lobes appear simultaneously or in close succession. The posteroventral lobes in the apical position on thoracic femora appear to be the precursors to multiple positive rate shifts in the evolutionary accumulation of cryptic features. One shift occurred early in the evolution of Vatinae while the second occurred much later, after the loss and re‐evolution of the posteroventral lobes in the apical position on thoracic femora, a violation of Dollo's law.This published work has been registered in ZooBank, http://zoobank.org/urn:lsid:zoobank.org:pub:724C16AF-069A-46A1-B66C-007D8DE18C68.
Promoting brain health through exercise and diet in older adults: a physiological perspective
Authors: Jackson Philippa A. , Pialoux Vincent , Corbett Dale , Drogos Lauren , Erickson Kirk I. , Eskes Gail A. , Poulin Marc J. 
Published: November 2015

AbstractThe rise in incidence of age‐related cognitive impairment is a global health concern. Ageing is associated with a number of changes in the brain that, collectively, contribute to the declines in cognitive function observed in older adults. Structurally, the ageing brain atrophies as white and grey matter volumes decrease. Oxidative stress and inflammation promote endothelial dysfunction thereby hampering cerebral perfusion and thus delivery of energy substrates and nutrients. Further, the development of amyloid plaques and neurofibrillary tangles contributes to neuronal loss. Of interest, there are substantial inter‐individual differences in the degree to which these physical and functional changes impact upon cognitive function as we grow older. This review describes how engaging in physical activity and cognitive activities and adhering to a Mediterranean style diet promote ‘brain health’. From a physiological perspective, we discuss the effects of these modifiable lifestyle behaviours on the brain, and how some recent human trials are beginning to show some promise as to the effectiveness of lifestyle behaviours in combating cognitive impairment. Moreover, we propose that these lifestyle behaviours, through numerous mechanisms, serve to increase brain, cerebrovascular and cognitive reserve, thereby preserving and enhancing cognitive function for longer.
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Detection of masses in digital breast tomosynthesis using complementary information of simulated projection
Authors: Kim Seong Tae , Kim Dae Hoe , Ro Yong Man 
Published: November 2015

Purpose:The purpose of this study is to develop a computer‐aided detection system that combines the detection results in 3D digital breast tomosynthesis (DBT) volume and 2D simulated projection (synthesized image which is not provided by the vendor but generated from DBT volume in this study) to improve the accuracy of mass detection in DBT.Methods:The 3D DBT volume has a problem of blurring in the out‐of‐focus plane because it is reconstructed from a limited number of projection view images acquired over a limited angular range. To solve the problem, the simulated projection is generated by measuring the blurriness of voxels in the DBT volume and adopting conspicuity voxels. A contour‐based detection algorithm is applied to detecting masses in the simulated projection. The DBT volume is analyzed by using an unsupervised mass detection algorithm, which results in mass candidates in the DBT volume. The mass likelihood scores estimated for mass candidates on the DBT volume and the simulated projection are merged in a probabilistic manner through a Bayesian network model to differentiate masses and false positives (FPs). Experiments were conducted on a clinical data set of 320 DBT volumes. In 90 volumes, at least one biopsy‐proven malignant mass was presented. The longest diameter of masses ranged from 7.0 to 56.4 mm (mean = 25.4 mm). The sizes of masses in the data set were relatively large compared to the sizes of the masses reported in other detection studies. Three image quality measurements (overall sharpness, sharpness of mass boundary, and contrast) were used to evaluate the image quality of the simulated projection compared to the DBT central slice where the mass was most conspicuous and other projection methods (maximum intensity projection and average projection). A free‐response receiver operating characteristic (FROC) analysis was adopted for evaluating the accuracy of mass detection in the DBT volume, the simulated projection, and the combined approach. A jackknife FROC analysis (JAFROC) was used to estimate the statistical significance of the difference between two FROC curves.Results:The overall sharpness and the sharpness of mass boundary in the simulated projection are higher than those in the DBT central slice and other projection methods. The contrast of the simulated projection is lower than the DBT central slice. The mass detection in the DBT volume achieved region‐based sensitivities of 80% and 85% with 1.75 and 2.11 FPs per DBT volume. The proposed combined mass detection approach achieved same sensitivities with reduced FPs of 1.33 and 1.93 per DBT volume. The difference of the FROC curves between the combined approach and the mass detection in the DBT volume was statistically significant (p < 0.01) by JAFROC analysis.Conclusions:This study indicates that the combined approach that merges the detection results in the DBT volume and the simulated projection is a promising approach to improve the accuracy of mass detection in DBT.
Drug Susceptibility and Viral Fitness of HIV-1 with Integrase Strand Transfer Inhibitor Resistance Substitution Q148R or N155H in Combination with Nucleoside/Nucleotide Reverse Transcriptase Inhibitor Resistance Substitutions
Authors: Andreatta Kristen N. , Miller Michael D. , White Kirsten L. 
Published: November 2015

ABSTRACT

In clinical trials of coformulated elvitegravir (EVG), cobicistat (COBI), emtricitabine (FTC), and tenofovir disoproxil fumarate (TDF), emergent drug resistance predominantly involved the FTC resistance substitution M184V/I in reverse transcriptase (RT), with or without the tenofovir (TFV) resistance substitution K65R, accompanied by a primary EVG resistance substitution (E92Q, N155H, or Q148R) in integrase (IN). We previously reported that the RT-K65R, RT-M184V, and IN-E92Q substitutions lacked cross-class phenotypic resistance and replicative fitness compensation. As a follow-up, the
in vitro
characteristics of mutant HIV-1 containing RT-K65R and/or RT-M184V with IN-Q148R or IN-N155H were also evaluated, alone and in combination, for potential interactions. Single mutants displayed reduced susceptibility to their corresponding inhibitor classes, with no cross-class resistance. Viruses with IN-Q148R or IN-N155H exhibited reduced susceptibility to EVG (137- and 40-fold, respectively) that was not affected by the addition of RT-M184V or RT-K65R/M184V. All viruses containing RT-M184V were resistant to FTC (>1,000-fold). Mutants with RT-K65R had reduced susceptibility to TFV (3.3- to 3.6-fold). Without drugs present, the viral fitness of RT and/or IN mutants was diminished relative to that of the wild type in the following genotypic order: wild type > RT-M184V ≥ IN-N155H ≈ IN-Q148R ≥ RT-M184V + IN-N155H ≥ RT-M184V + IN-Q148R ≥ RT-K65R/M184V + IN-Q148R ≈ RT-K65R/M184V + IN-N155H. In the presence of drug concentrations approaching physiologic levels, drug resistance counteracted replication defects, allowing single mutants to outcompete the wild type with one drug present and double mutants to outcompete single mutants with two drugs present. These results suggest that during antiretroviral treatment with multiple drugs, the development of viruses with combinations of resistance substitutions may be favored despite diminished viral fitness.
Distinctive Binding of Avibactam to Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria
Authors: Asli Abdelhamid , Brouillette Eric , Krause Kevin M. , Nichols Wright W. , Malouin François 
Published: November 2015

ABSTRACTAvibactam is a novel non-β-lactam β-lactamase inhibitor that covalently acylates a variety of β-lactamases, causing inhibition. Although avibactam presents limited antibacterial activity, its acylation ability toward bacterial penicillin-binding proteins (PBPs) was investigated.Staphylococcus aureuswas of particular interest due to the reported β-lactamase activity of PBP4. The binding of avibactam to PBPs was measured by adding increasing concentrations to membrane preparations of a variety of Gram-positive and Gram-negative bacteria prior to addition of the fluorescent reagent Bocillin FL. Relative binding (measured here as the 50% inhibitory concentration [IC50]) to PBPs was estimated by quantification of fluorescence after gel electrophoresis. Avibactam was found to selectively bind to some PBPs. InEscherichia coli,Pseudomonas aeruginosa,Haemophilus influenzae, andS. aureus, avibactam primarily bound to PBP2, with IC50s of 0.92, 1.1, 3.0, and 51 μg/ml, respectively, whereas binding to PBP3 was observed inStreptococcus pneumoniae(IC50, 8.1 μg/ml). Interestingly, avibactam was able to significantly enhance labeling ofS. aureusPBP4 by Bocillin FL. In PBP competition assays withS. aureus, where avibactam was used at a fixed concentration in combination with varied amounts of ceftazidime, the apparent IC50of ceftazidime was found to be very similar to that determined for ceftazidime when used alone. In conclusion, avibactam is able to covalently bind to some bacterial PBPs. Identification of those PBP targets may allow the development of new diazabicyclooctane derivatives with improved affinity for PBPs or new combination therapies that act on multiple PBP targets.
Exotic leptons: Collider and muon magnetic moment constraints
Authors: Cogollo D. 
Published: November 2015

In light of the ongoing effort on reducing the theoretical uncertainties and an upcoming experiment concerning muon magnetic moment, we perform a detailed study of an 3-4-1 electroweak gauge extension of the standard model that contains exotic charged leptons in its spectrum. We discuss flavor changing neutral current, collider and electroweak bounds on the model and derive [Formula: see text] limits using current and projected limits on the muon magnetic moment. In summary, we exclude the masses of new gauge bosons that couple to muons and heavy charged leptons up to 700 GeV. Moreover, we find a projected lower bound on the scale of symmetry breaking to be 2 TeV.
Helping to Make Sense of Regional Climate Modeling: Professional Development for Scientists and Decision-Makers Anytime, Anywhere
Authors: Walton Peter J. , Yarker Morgan B. , Mesquita Michel D. S. , Otto Friederike E. L. 
Published: November 2015

Abstract
Globally, decision-makers are increasingly using high-resolution climate models to support policy and planning; however, many of these users do not have the knowledge needed to use them appropriately. This problem is compounded by not having access to quality learning opportunities to better understand how to apply the models and interpret results. This paper discusses and proposes an educational framework based on two independent online courses on regional climate modeling, which addresses the accessibility issue and provides guidance to climate science professors, researchers, and institutions who want to create their own online courses.
The role of e-learning as an educational tool is well documented, highlighting the benefits of improved personal efficiency through “anywhere, anytime” learning with the flexibility to support professional development across different sectors. In addition, improved global Internet means increased accessibility. However, e-learning’s function as a tool to support understanding of atmospheric physics and high-resolution climate modeling has not been widely discussed. To date, few courses, if any, support understanding that takes full advantage of e-learning best practices.
There is a growing need for climate literacy to help inform decision-making on a range of scales, from individual households to corporate CEOs. And while there is a plethora of climate information online, educational theory suggests that people need to be guided in how to convert this information into applicable knowledge.
Here, we present how the experience of the courses we designed and ran independent of each other, both engaging learners with better understanding benefits and limitations of regional climate modeling, lead to a framework of designing e-learning for climate modeling.
Visualizing Vapor Pressure: A Mechanical Demonstration of Liquid–Vapor Phase Equilibrium
Authors: Lamb Dennis , Shaw Raymond A. 
Published: November 2015

Abstract
Water phase transitions are central to climate and weather. Yet it is a common experience that the principles of phase equilibrium are challenging to understand and teach. A simple mechanical analogy has been developed to demonstrate key principles of liquid evaporation and the temperature dependence of equilibrium vapor pressure. The system is composed of a circular plate with a central depression and several hundred metal balls. Mechanical agitation of the plate causes the balls to bounce and interact in much the same statistical way that molecules do in real liquid–vapor systems. The data, consisting of the number of balls escaping the central well at different forcing energies, exhibit a logarithmic dependence on the reciprocal of the applied energy (analogous to thermal energy kBT) that is similar to that given by Boltzmann statistics and the Clausius–Clapeyron equation. These results demonstrate that the enthalpy (i.e., latent heat) of evaporation is well interpreted as the potential energy difference between molecules in the vapor and liquid phases, and it is the fundamental driver of vapor pressure increase with temperature. Consideration of the uncertainties in the measurements shows that the mechanical system is described well by Poisson statistics. The system is simple enough that it can be duplicated for qualitative use in atmospheric science teaching, and an interactive animation based on the mechanical system is available online for instructional use (http://phy.mtu.edu/vpt/).
Impact of Two Distinct Teleconnection Patterns Induced by Western Central Pacific SST Anomalies on Korean Temperature Variability during the Early Boreal Summer
Authors: Ham Yoo-Geun , Kug Jong-Seong , Yeh Sang-Wook , Kwon Minho 
Published: November 2015

Abstract
This study investigates the impact of western central Pacific sea surface temperatures (SSTs) on the temperature variability over the Korea Peninsula during the early boreal summer season. The authors found a significant positive correlation between June temperature anomalies across the Korea Peninsula and a horseshoe pattern of ENSO-related SST anomalies in the western central Pacific during May. While this SST pattern is relatively stationary throughout the boreal summer, the SST-driven atmospheric teleconnection exhibits dramatic subseasonal changes. During May, positive precipitation anomalies caused by SST warming in the northern central Pacific (NCP; 20°–30°N, 160°E–160°W) induce a wave train extending in a northwest–southeast direction. During June, while this wave train pattern is weakened, a Pacific–Japan (PJ) pattern is formed by positive precipitation anomalies over the off-equatorial western Pacific (off-WP). Even though dramatic subseasonal changes exist in the teleconnection patterns, both patterns contribute to temperature warming over Korea. It is shown that the subseasonal change in the atmospheric teleconnection is caused by changes in climatological precipitation. During May, significant climatological precipitation related to the pre-mei-yu and pre-baiu fronts occurs over the NCP. These wet background conditions provide a favorable environment for anomalous convection over the NCP but not over the off-equatorial western Pacific. On the other hand, during June, convective activities over the off-WP result in the formation of a PJ pattern, enhanced by an increase in climatological precipitation associated with the activation of the western North Pacific (WNP) monsoon. These results indicate that climatological conditions play an important role in the formation of atmospheric teleconnection linking Pacific and East Asian climates.
Long-Term Morphological Changes in Simulated Supercells Following Mergers with Nascent Supercells in Directionally Varying Shear
Authors: Hastings Ryan , Richardson Yvette 
Published: November 2015

Abstract
Mergers involving supercells remain a challenge for severe thunderstorm forecasting. In this study, mergers between supercells and ordinary cells (e.g., cells forming in a similar environment but too young to be fully developed supercells) are investigated. A series of numerical experiments are performed using an idealized, homogenous environment supportive of cyclonically rotating, right-moving supercells. Warm bubbles are introduced at different times, resulting in two storms of different maturity; their placement is used to control the location of the merger and the relative maturity of the second storm. Simplified conceptual models for the long-term outcomes of mergers are developed. In the simplest mode of merger, outflow from the new cell cuts off inflow to the original. If the new cell’s cold pool is not sufficiently strong to cut off the inflow to the original cell, the minimum separation of the updraft maxima during the merger becomes a key controlling factor in the outcome. If it is less than 10 km, an updraft collision occurs, resulting in a classic supercell. If it is greater than 20 km and the new cell merges into the original cell’s forward flank, a dual-cell system results. If it is between 10 and 20 km, the enhanced precipitation produced during the merger leads to a cold pool surge and an updraft bridge, joining the original updrafts and developing into either a small bow echo (with forward-flank mergers) or a supercell on the classic high-precipitation spectrum (with rear-flank mergers), depending on the distribution of precipitation in the merging system.