bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transforming Growth Factor-β1 Inhibits Pseudoaneurysm Formation After Aortic Patch Angioplasty
Authors: Bai Hualong , Lee Jung Seok , Hu Haidi , Wang Tun , Isaji Toshihiko , Liu Shirley , Guo Jianming , Liu Haiyang , Wolf Katharine , Ono Shun , Guo Xiangjiang , Yatsula Bogdan , Xing Ying , Fahmy Tarek M. , Dardik Alan 
Published: November 2017

Objective—
Pseudoaneurysms remain a significant complication after vascular procedures. We hypothesized that TGF-β (transforming growth factor-β) signaling plays a mechanistic role in the development of pseudoaneurysms.

Approach and Results—
Rat aortic pericardial patch angioplasty was associated with a high incidence (88%) of pseudoaneurysms at 30 days, with increased smad2 phosphorylation in small pseudoaneurysms but not in large pseudoaneurysms; TGF-β1 receptors were increased in small pseudoaneurysms and preserved in large pseudoaneurysms. Delivery of TGF-β1 via nanoparticles covalently bonded to the patch stimulated smad2 phosphorylation both in vitro and in vivo and significantly decreased pseudoaneurysm formation (6.7%). Inhibition of TGF-β1 signaling with SB431542 decreased smad2 phosphorylation both in vitro and in vivo and significantly induced pseudoaneurysm formation by day 7 (66.7%).

Conclusions—
Normal healing after aortic patch angioplasty is associated with increased TGF-β1 signaling, and recruitment of smad2 signaling may limit pseudoaneurysm formation; loss of TGF-β1 signaling is associated with the formation of large pseudoaneurysms. Enhancement of TGF-β1 signaling may be a potential mechanism to limit pseudoaneurysm formation after vascular intervention.
STABLE-SR (Electrophysiological Substrate Ablation in the Left Atrium During Sinus Rhythm) for the Treatment of Nonparoxysmal Atrial Fibrillation
Authors: Yang Bing , Jiang Chenyang , Lin Yazhou , Yang Gang , Chu Huimin , Cai Heng , Lu Fengmin , Zhan Xianzhang , Xu Jian , Wang Xinhua , Ching Chi-Keong , Singh Balbir , Kim Young-Hoon , Chen Minglong 
Published: November 2017

Background:
Circumferential pulmonary vein isolation (CPVI) alone or combined with adjuvant substrate modifications is unsatisfactory for atrial fibrillation (AF) control in nonparoxysmal AF patients. Ablation targeting the fibrotic areas after CPVI (STABLE-SR [Electrophysiological Substrate Ablation in the Left Atrium During Sinus Rhythm]) is a newly evolved substrate modification strategy.

Methods and Results:

In this multicenter, randomized clinical trial, 229 symptomatic nonparoxysmal AF patients were 1:1 randomized to STABLE-SR group (n=114) or conventional STEPWISE group (n=115). In the STABLE-SR group, after CPVI, cavotricuspid isthmus ablation and cardioversion to sinus rhythm, left atrial high-density mapping was performed. Areas with low-voltage and complex electrogram were further homogenized and eliminated, respectively. Dechanneling would be done if necessary. In the STEPWISE group, additional linear lesions and defragmentation were performed.The primary end point was freedom from documented atrial tachyarrhythmias for ≥30 s after a single ablation procedure without antiarrhythmic medications at 18 months. At 18 months, 74.0% of the patients in the STABLE-SR group and 71.5% in the STEPWISE group (hazard ratio, 0.78; 95% confidence interval, 0.47–1.29;
P
=0.325) achieved success according to intention-to-treat analysis. However, less procedure time (186.8±52.7 versus 210.5±48.0 minutes,
P
<0.001), reduced post-CPVI fluoroscopic time (11.0±7.8 versus 13.7±8.9 minutes,
P
=0.006), and shorter energy delivery time (60.1±25.1 versus 75.0±24.3 minutes,
P
<0.001) were observed in the STABLE-SR group compared with the STEPWISE group.

Conclusions:
STABLE-SR is a simplified, personalized, and effective ablation strategy in nonparoxysmal AF patients. More importantly, over 50% nonparoxysmal AF patients do not need further ablation beyond CPVI and therefore can avoid excessive ablation.

Clinical Trial Registration:

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01761188.
Impact of Diabetes Mellitus on Outcomes in Patients Supported With Left Ventricular Assist Devices
Authors: Asleh Rabea , Briasoulis Alexandros , Schettle Sarah D. , Tchantchaleishvili Vakhtang , Pereira Naveen L. , Edwards Brooks S. , Clavell Alfredo L. , Maltais Simon , Joyce David L. , Joyce Lyle D. , Daly Richard C. , Kushwaha Sudhir S. , Stulak John M. 
Published: November 2017

Background
Diabetes mellitus (DM) is a risk factor for morbidity and mortality in patients with heart failure. The effect of DM on post–left ventricular assist device (LVAD) implantation outcomes is unclear. This study sought to investigate whether patients with DM had worse outcomes than patients without DM after LVAD implantation and whether LVAD support resulted in a better control of DM.

Methods and Results

We retrospectively reviewed 341 consecutive adults who underwent implantation of LVAD from 2007 to 2016. Patient characteristics and adverse events were studied and compared between patients with and without DM. One hundred thirty-one patients (38%) had DM. Compared with patients without DM, those with DM had higher rates of ischemic cardiomyopathy, LVAD implantation as destination therapy, and increased baseline body mass index. In a proportional hazards (Cox) model with adjustment for relevant covariates and median follow-up of 16.1 months, DM was associated with increased risk of all-cause mortality (hazard ratio, 1.73; 95% confidence interval: 1.18–2.53;
P
=0.005) and increased risk of nonfatal LVAD-related complications, including a composite of stroke, pump thrombosis, and device infection (hazard ratio, 2.1; 95% confidence interval: 1.35–3.18;
P
=0.001). Preoperative hemoglobin A1c was not significantly associated with mortality or adverse events among patients with DM. LVAD implantation resulted in a remarkable decrease in hemoglobin A1c levels (7.4±1.9 pre-LVAD versus 6.0±1.5 and 6.3±1.4 after 3 and 12 months post-LVAD, respectively;
P
<0.0001) and a significant reduction in requirements of DM medications.

Conclusions
DM is associated with increased rates of all-cause mortality and major adverse events despite favorable glycemic control after LVAD implantation.
Contemporary Characteristics and Outcomes in Chagasic Heart Failure Compared With Other Nonischemic and Ischemic Cardiomyopathy
Authors: Shen Li , Ramires Felix , Martinez Felipe , Bodanese Luiz Carlos , Echeverría Luis Eduardo , Gómez Efraín A. , Abraham William T. , Dickstein Kenneth , Køber Lars , Packer Milton , Rouleau Jean L. , Solomon Scott D. , Swedberg Karl , Zile Michael R. , Jhund Pardeep S. , Gimpelewicz Claudio R. , McMurray John J.V. ,   on behalf of the PARADIGM-HF and ATMOSPHERE Investigators and Committees
Published: November 2017

Background
Chagas’ disease is an important cause of cardiomyopathy in Latin America. We aimed to compare clinical characteristics and outcomes in patients with heart failure (HF) with reduced ejection fraction caused by Chagas’ disease, with other etiologies, in the era of modern HF therapies.

Methods and Results

This study included 2552 Latin American patients randomized in the PARADIGM-HF (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) and ATMOSPHERE (Aliskiren Trial to Minimize Outcomes in Patients With Heart Failure) trials. The investigator-reported etiology was categorized as Chagasic, other nonischemic, or ischemic cardiomyopathy. The outcomes of interest included the composite of cardiovascular death or HF hospitalization and its components and death from any cause. Unadjusted and adjusted Cox proportional hazards models were performed to compare outcomes by pathogenesis. There were 195 patients with Chagasic HF with reduced ejection fraction, 1300 with other nonischemic cardiomyopathy, and 1057 with ischemic cardiomyopathy. Compared with other etiologies, Chagasic patients were more often female, younger, and had lower prevalence of hypertension, diabetes mellitus, and renal impairment (but had higher prevalence of stroke and pacemaker implantation) and had worse health-related quality of life. The rates of the composite outcome were 17.2, 12.5, and 11.4 per 100 person-years for Chagasic, other nonischemic, and ischemic patients, respectively—adjusted hazard ratio for Chagasic versus other nonischemic: 1.49 (95% confidence interval, 1.15–1.94;
P
=0.003) and Chagasic versus ischemic: 1.55 (1.18–2.04;
P
=0.002). The rates of all-cause mortality were also higher.

Conclusions
Despite younger age, less comorbidity, and comprehensive use of conventional HF therapies, patients with Chagasic HF with reduced ejection fraction continue to have worse quality of life and higher hospitalization and mortality rates compared with other etiologies.

Clinical Trial Registration

PARADIGM-HF: URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01035255; ATMOSPHERE: URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00853658.
Risk of Stroke in Patients With Short-Run Atrial Tachyarrhythmia
Authors: Yamada Shinya , Lin Chin-Yu , Chang Shih-Lin , Chao Tze-Fan , Lin Yenn-Jiang , Lo Li-Wei , Chung Fa-Po , Hu Yu-Feng , Tuan Ta-Chuan , Liao Jo-Nan , Te Abigail Louise D. , Chang Yao-Ting , Chang Ting-Yung , Wu Cheng-I , Higa Satoshi , Chen Shih-Ann 
Published: November 2017

Background and Purpose—

The risk of stroke in patients with short-run atrial tachyarrhythmia (AT) remains unclear. This study aimed to investigate the relationship between short-run AT and the stroke and the use of the CHA
2
DS
2
-VASc score for the risk stratification.

Methods—
From the registry of 24-hour Holter monitoring, 5342 subjects without known atrial fibrillation or stroke were enrolled. Short-run AT was defined as episodes of supraventricular ectopic beats <5 seconds.

Results—

There were 1595 subjects (29.8%) with short-run AT. During the median follow-up period of 9.0 years, 494 subjects developed new-onset stroke. Patients with short-run AT had significantly higher stroke rates compared with patients without short-run AT (11.4% versus 8.3%;
P
<0.001). In patients with short-run AT, the number of strokes per 100 person-years for patients with CHA
2
DS
2
-VASc score of 0 and 1 were 0.23 and 0.67, respectively. However, the number of them for patients with CHA
2
DS
2
-VASc score of 2, 3, 4, and ≥5 were 1.62, 1.89, 1.30, and 2.91, respectively. In patients with CHA
2
DS
2
-VASc score of 0 or 1, age (>61 years old) and burden of premature atrial contractions (>25 beats/d) independently predicted the risk of stroke. In subgroup analyses, short-run AT patients were divided into 3 groups based on their CHA
2
DS
2
-VASc scores: low score (score of 0 [men] or 1 [women]; n=324), intermediate score (score of 1 [men] or 2 [women]; n=275), and high score (score of ≥2 [men] or ≥3 [women]; n=996). When compared with low score, intermediate and high scores were independent predictors for stroke (hazard ratio, 6.165;
P
<0.001 and hazard ratio, 8.577;
P
<0.001, respectively).

Conclusions—

Short-run AT increases the risk of stroke. Therefore, the CHA
2
DS
2
-VASc score could be used for the risk stratification. Age and burden of premature atrial contractions were independent predictors for stroke in patients with CHA
2
DS
2
-VASc score of 0 or 1.
Decreased activation and subsyndromal manic symptoms predict lower remission rates in bipolar depression
Authors: Caldieraro Marco Antonio , Walsh Samantha , Deckersbach Thilo , Bobo William V , Gao Keming , Ketter Terence A , Shelton Richard C , Reilly-Harrington Noreen A , Tohen Mauricio , Calabrese Joseph R , Thase Michael E , Kocsis James H , Sylvia Louisa G , Nierenberg Andrew A 
Published: November 2017

Objective: Activation encompasses energy and activity and is a central feature of bipolar disorder. However, the impact of activation on treatment response of bipolar depression requires further exploration. The aims of this study were to assess the association of decreased activation and sustained remission in bipolar depression and test for factors that could affect this association. Methods: We assessed participants with Diagnostic and Statistical Manual of Mental Disorders (4th ed) bipolar depression ( n = 303) included in a comparative effectiveness study of lithium- and quetiapine-based treatments (the Bipolar CHOICE study). Activation was evaluated using items from the Bipolar Inventory of Symptoms Scale. The selection of these items was based on a dimension of energy and interest symptoms associated with poorer treatment response in major depression. Results: Decreased activation was associated with lower remission rates in the raw analyses and in a logistic regression model adjusted for baseline severity and subsyndromal manic symptoms (odds ratio = 0.899; p = 0.015). The manic features also predicted lower remission (odds ratio = 0.934; p < 0.001). Remission rates were similar in the two treatment groups. Conclusion: Decreased activation and subsyndromal manic symptoms predict lower remission rates in bipolar depression. Patients with these features may require specific treatment approaches, but new studies are necessary to identify treatments that could improve outcomes in this population.
Increased serum levels of mBDNF in women with minimal and mild endometriosis have no predictive power for the disease
Authors: Perricos Alexandra , Ashjaei Kazem , Husslein Heinrich , Proestling Katharina , Kuessel Lorenz , Obwegeser Reinhard , Wenzl Rene , Yotova Iveta 
Published: November 2017

The objective of our pilot clinical, prospective study was to determine the serum levels of mature brain-derived neurotrophic factor, in of women with endometriosis and controls and explore whether mature brain-derived neurotrophic factor is a potential biomarker for the disease. The patients were selected from the Endometriosis Marker Austria prospective cohort study conducted at the tertiary referral certified Endometriosis Center of the Medical University of Vienna. All women underwent laparoscopic surgery because there was a suspicion of endometriosis, or the women had pelvic pain, adnexal cysts, unexplained infertility, or uterine fibroids. Our main outcome parameter was total levels of mature brain-derived neurotrophic factor in serum, measured using ELISA. Our results show that serum levels of mature brain-derived neurotrophic factor are significantly higher in women with endometriosis compared to women without endometriosis. The mean serum protein levels are significantly higher in women with rAFS stage I and II endometriosis, whereas no difference was found in women with stage III and IV endometriosis and controls. Postoperative follow-up at 6–10 weeks revealed that surgical intervention leads to equilibration of the levels of secreted mature brain-derived neurotrophic factor between women with and without endometriosis. The difference between serum mature brain-derived neurotrophic factor levels of women with endometriosis compared to women without endometriosis is independent of menstrual cycle phase and overall self-reported pelvic pain. ROC-curve analysis showed that, the mature brain-derived neurotrophic factor is not a useful biomarker for endometriosis. In conclusion, although women with stage I and II endometriosis have increased levels of mature brain-derived neurotrophic factor in serum compared to controls, the difference is not predictive for the disease.Impact statementEndometriosis is a disease that can have a significant impact on the quality of life of affected women. The gold standard for diagnosis to this day remains visualization through laparoscopic surgery with histological verification. Current studies are attempting to find a biomarker with high sensitivity and specificity, which would bypass the surgery-associated risks and would significantly reduce costs. In an attempt to elucidate whether mature serum BDNF can serve as diagnostic marker for the disease, we compared the levels of the protein in women with endometriosis to endometriosis-free controls. While our results showed that serum concentrations of the mature protein were significantly higher in women with endometriosis, we did not find this marker to have the sensitivity or specificity needed in order to allow a reliable diagnosis.
Incremental temperature cement delivery technique may prevent cement leakage in metastatic vertebral lesions
Authors: Liu Hao , Wang Shenghao , Liu Tao , Meng Bin , He Fan , Zhou Rong , Yang Huilin 
Published: November 2017

Objectives: To analyze the clinical efficacy and cement leakage rate of percutaneous kyphoplasty (PKP) for the treatment of metastatic vertebral lesions between the two groups using different cement infusion techniques. Methods: One hundred twenty-nine patients (160 metastatic vertebral fractures) who chose “the incremental temperature cement delivery technique” (ITCDT group) and 105 patients (128 metastatic vertebral fractures) who chose “traditional infusion technique” (TI group) were finally enrolled (nine patients were lost to the follow-up). The visual analog scale (VAS), Oswestry Disability Index (ODI), the local Cobb’s angle, the relative height of the vertebral anterior border, and cement leakage were analyzed to evaluate the clinical efficacy of the two cement infusion techniques within postoperative 12 months. Results: There was no significant difference in the VAS scores, ODI scores, the relative height of the vertebral anterior border, and local Cobb’s angle between the ITCDT group and TI group preoperatively and postoperatively ( p > 0.05). The cement leakage occurred in three patients of ITCDT group (2.3%), which was significantly less than TI group (12 patients, 11.4%; p < 0.05). Conclusions: The ITCDT and TI technique in kyphoplasty are effective at relieving pain and improving functional disability, vertebral height, and kyphosis angle; However, kyphoplasty using the ITCDT causes less cement leakage significantly.
Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice
Authors: Kon Ayana , Yamazaki Satoshi , Nannya Yasuhito , Kataoka Keisuke , Ota Yasunori , Nakagawa Masahiro Marshall , Yoshida Kenichi , Shiozawa Yusuke , Morita Maiko , Yoshizato Tetsuichi , Sanada Masashi , Nakayama Manabu , Koseki Haruhiko , Nakauchi Hiromitsu , Ogawa Seishi 
Published: November 2017

Key Points
Blood-specific expression of the Srsf2 P95H mutant results in decreased stem/progenitor cell numbers and a reduced repopulation capacity. Srsf2 P95H mutation by itself is not sufficient to develop MDS but contributes to the MDS phenotype in transplantation settings.
CD86 regulates myeloma cell survival
Authors: Gavile Catherine M. , Barwick Benjamin G. , Newman Scott , Neri Paola , Nooka Ajay K. , Lonial Sagar , Lee Kelvin P. , Boise Lawrence H. 
Published: November 2017

Key Points
CD86 mediates myeloma survival via activity from its cytoplasmic tail and the CD28-CD86 interaction facilitates stromal independence. Blocking the CD28-CD86 pathway is a promising therapeutic avenue for myeloma, as there are already approved agents that target this pathway.
Correction to: (Un)beliveable wages? An analysis of minimum wage policies in Europe from a living wage perspective
Authors: Fabo Brian , Belli Sharon Sarah 
Published: November 2017

Correction to: IZA journal of labor policy (2017) 6:4 DOI: 10.1186/s40173-017-0083-3
In the original version of this article (Fabo & Belli, 2017), published on 16 March 2017, the values for Minimum Wages (MW) in the Table 2 are incorrect. This also affected both the paragraph describing the values in Table 2 and Fig. 2. In this Correction the incorrect and correct version of Table 2, of its accompanying paragraph and of Fig. 2 are shown.
Ideology and the text-in-context relation
Authors: Lukin Annabelle 
Published: November 2017

AbstractWhile aspects of Halliday’s theory have been adopted for the study of ideology in discourse - in particular via Critical Discourse Analysis - these applications of his ideas have not attempted to bring the full weight of Halliday’s model to the problem of understanding the phenomenon and practical manifestation of ideology. A consideration of Halliday’s model reveals, first of all, that Halliday, like Vološinov in linguistics, and Mannheim in sociology, sees ideology as entirely pervasive. The act of analysing ideology is, therefore, ideological, a conundrum known as ‘Mannheim’s paradox’. This paradox, rather than hindering the study of ideology, invites the researcher to work explicitly with the concepts in one’s theoretical model, and to test their usefulness in producing robust and revealing descriptions of the ideologies that shape human experience and behaviour. This paper explores ideology in the context of the ‘architecture’ of human language, that is, with reference to key concepts in Halliday’s theory, including realisation/stratification, instantiation, register and context of situation and of culture. I argue that while ideology is permeable with respect to register - the same ideology can be expressed across a variety of contexts - the concepts of context and register are crucial to showing the affordances of particular registers to the dissemination of specific ideologies. I illustrate this claim by analysing one text with respect to its context of situation (drawing on Hasan’s context networks) and its context of culture. I consider how the text, as an instance of a particular register, is an ideal host for ideological meanings that legitimate organised violence in the pursuit of geopolitical power.
Treatment of Parotid Non-Hodgkin Lymphoma: A Meta-Analysis
Authors: Jamal Basem 
Published: November 2017

Purpose This meta-analysis aimed to review the published outcomes of parotid non-Hodgkin lymphoma (NHL) pertaining to different treatment modalities. Materials and Methods A total of 48 journal articles published between 1993 and 2015, comprising 742 cases of parotid NHL, were initially evaluated. In total, 108 patients from 12 studies who had sufficient data for analysis, including age, tumor histopathology, treatment modality, and outcome at final follow-up, were included. Patients were randomly assigned to different categories on the basis of histopathology and treatment modality. Groups were compared using Kaplan-Meier survival curve analysis and the Mann-Whitney U test. Results Log-rank tests demonstrated that for early-stage (I and II) parotid NHL of all histopathology variants, radiation therapy significantly improved the survival rate versus chemotherapy ( P = .043), as well as combined treatment with chemotherapy and radiation therapy ( P = .023). For early-stage diffuse large B-cell lymphoma, combined treatment significantly improved survival versus single treatment ( P = .028). No treatment was received by seven patients with early-stage mucosa-associated lymphoid tissue lymphoma after undergoing parotidectomy. When the clinical outcomes of these patients were compared with those of other patients with the same histology who underwent further treatment, no significant differences were noted in survival outcomes. Conclusion Radiation therapy seems to be a valid treatment of early-stage parotid NHL. However, for diffuse large B-cell lymphoma, survival was higher with combined treatment versus single treatment. For early-stage parotid mucosa-associated lymphoid tissue lymphoma, complete excision of the tumor through superficial parotidectomy may have similar survival outcome.