bluuebunny/crossref_metadata_2025_split huggingface dataset:
Head and neck squamous cell carcinoma: Ambiguous human papillomavirus status, elevated p16, and deleted retinoblastoma 1
Authors: Beck Tim N. , Smith Chad H. , Flieder Douglas B. , Galloway Thomas J. , Ridge John A. , Golemis Erica A. , Mehra Ranee 
Published: November 2016

ABSTRACTBackgroundHead and neck squamous cell carcinoma (HNSCC) is potentially curable, but treatment planning remains a challenge. Oncogenic human papillomavirus (HPV)‐positive disease is often associated with a good prognosis compared with HPV‐negative disease. However, some HPV‐positive HNSCC recurs, often with distant metastases and significant treatment resistance.Methods and ResultsWe performed p16 immunohistochemistry (IHC), in situ hybridization (ISH) for high‐risk HPV, and comprehensive genomic profiling on oropharyngeal HNSCC with basaloid features and particularly aggressive disease course, noting a rare genetic event: a deleting mutation (exons 5–17) of the tumor suppressor and dominant cell cycle regulator retinoblastoma 1 (RB1). Genomic and transcriptomic data available through FoundationOne and The Cancer Genome Atlas (TCGA) were reviewed for additional HNSCC cases with RB1 alterations.ConclusionRB1 alterations may have important prognostic implications, particularly in the context of high p16 expression, in both HPV‐positive and HPV‐negative HNSCC. © 2016 Wiley Periodicals, Inc. Head Neck 39: E34–E39, 2017
Prenatal detection of 10q22q23 duplications: dilemmas in phenotype prediction
Authors: Kong Grace Wing Shan , Cao Ye , Huang Jin , Cheng Kwun Yue , Pursley Amber Nolen , Rosenfeld Jill Anne , Edwards Janice G. , Chan Yiu Man , Cheung Sau Wai , Leung Tak Yeung , Choy Kwong Wai 
Published: November 2016

AbstractObjectivesThe phenotype for 10q22q23 duplication is diverse, ranging from intellectual disability and dysmorphism to normal development. Interpreting the clinical significance of the duplication identified in this region is difficult, especially in the prenatal setting. This study aimed to characterize the prenatal findings associated with this submicroscopic imbalance and discuss the dilemmas in predicting the phenotype of 10q22q23 duplications.MethodsThis is a retrospective study of three cases of 10q22q23 duplications diagnosed prenatally by chromosomal microarray analysis. Detailed pregnancy outcome and pediatric follow‐up were documented.ResultsThe genotypic and phenotypic features of the reported cases were discussed. 10q22q23 duplications are associated with an unpredictable and variable phenotypic outcome. Despite there was no phenotype found to be shared by 50% of the duplication cases, congenital heart defects, hypotelorism, and developmental delays including speech and motor delay seem to be more common.ConclusionsThe phenotype of 10q22q23 duplication is highly variable prenatally and postnatally. Identification of additional affected individuals with similar duplications is needed to provide further insights into the pathogenesis of this microduplication. © 2016 John Wiley & Sons, Ltd.
A protocol for pressurized liquid extraction and processing methods to isolate modern and ancient bone cholesterol for compound‐specific stable isotope analysis
Authors: Laffey Ann O. , Krigbaum John , Zimmerman Andrew R. 
Published: November 2016

RationaleBone lipid compound‐specific isotope analysis (CSIA) and bone collagen and apatite stable isotope ratio analysis are important sources of ecological and paleodietary information. Pressurized liquid extraction (PLE) is quicker and utilizes less solvent than traditional methods of lipid extraction such as soxhlet and ultrasonication. This study facilitates dietary analysis by optimizing and testing a standardized methodology for PLE of bone cholesterol.MethodsModern and archaeological bones were extracted by PLE using varied temperatures, solvent solutions, and sample weights. The efficiency of PLE was assessed via quantification of cholesterol yields. Stable isotopic ratio integrity was evaluated by comparing isotopic signatures (δ13C and δ18O values) of cholesterol derived from whole bone, bone collagen and bone apatite. Gas chromatography/mass spectrometry (GC/MS) and gas chromatography isotope ratio mass spectrometry (GC/IRMS) were conducted on purified collagen and lipid extracts to assess isotopic responses to PLE.ResultsLipid yield was optimized at two PLE extraction cycles of 75 °C using dichloromethane/methanol (2:1 v/v) as a solvent with 0.25–0.75 g bone sample. Following lipid extraction, saponification combined with the derivatization of the neutral fraction using trimethylsilylation yielded nearly twice the cholesterol of non‐saponified or non‐derivatized samples. It was also found that lipids extracted from purified bone collagen and apatite could be used for cholesterol CSIA. There was no difference in the bulk δ13C values of collagen extracted from bone with or without lipid. However, there was a significant depletion in 18O of bone apatite due to lipid presence or processing.ConclusionsThese results should assist sample selection and provide an effective, alternative extraction method for bone cholesterol that may be used for isotopic and paleodietary analysis. Copyright © 2016 John Wiley & Sons, Ltd.
Robust consensus tracking of linear multiagent systems with input saturation and input‐additive uncertainties
Authors: Wang Qingling , Sun Changyin , Xin Xin 
Published: November 2016

SummaryThe problem of robust global consensus tracking of linear multiagent systems with input saturation and input‐additive uncertainties is investigated in this paper. By using the parametric Lyapunov equation approach and an existing dynamic gain scheduling technique, a new distributed nonlinear‐gain scheduling consensus‐trackining algorithm is developed to solve this problem. Under the assumption that each agent is asymptotically null controllable with bounded control, it is shown that the robust global consensus tracking can be achieved under the undirected graph provided that its generated graph contains a directed spanning tree. Compared with the existing algebraic Riccati equation approach, which requires the online solution of a parameterized algebraic Riccati equation, all the parameters in the proposed nonlinear algorithm are offline determined a priori. Finally, numerical examples are provided to validate the theoretical results. Copyright © 2016 John Wiley & Sons, Ltd.
Recursive observer‐based fault detection for a class of nonlinear uncertain systems with output constraints
Authors: Zhang Zhi‐Hui , Yang Guang‐Hong 
Published: November 2016

SummaryThis paper investigates the fault detection (FD) problem for a class of nonlinear uncertain systems in strict feedback form with an output constraint. The key idea is to design an observer to generate the FD signals and the output estimate, which also satisfies the output constraint. To facilitate constraint handling, the constraints on the output and the output estimate are transformed into the output estimation error constraint. Then, the FD observer is designed in a recursive framework. By employing a barrier Lyapunov function, the output estimation error constraint is incorporated in the last step of the recursive observer design algorithm to prevent constraint violation. It is shown that the output estimation error is uniformly bounded and satisfies the constraint for the fault‐free case. Furthermore, the residual signal is constructed by the output estimation error, and its corresponding bound is used as threshold. Compared with the FD method without considering the constraints, the proposed FD scheme provides a smaller threshold and characterizes a larger set of faults, which can be detected. Finally, simulation results are presented to illustrate the benefits of the proposed FD scheme. Copyright © 2016 John Wiley & Sons, Ltd.
A survey on cloud forensics challenges and solutions
Authors: Simou Stavros , Kalloniatis Christos , Gritzalis Stefanos , Mouratidis Haralambos 
Published: November 2016

AbstractIn recent years, cloud computing has gained popularity, and it is now used to support various areas of human life. Cloud forensics has been introduced to help forensic investigators find potential evidence against cloud criminal activities and maintain the security and integrity of the information stored in the cloud. While great research in the area has been carried out concerning challenges and solutions, the research on methodologies and frameworks is still in its infancy. This article focuses on the methodological aspects of cloud forensics. It critically reviews cloud forensics' existing challenges and solutions, and it explores, based on a detailed review of the area, all the work that has been carried out both in digital and cloud forensic methodologies mainly for supporting the investigation of security incidents in cloud. Furthermore, the detailed comparison reveals similarities and drawbacks of the existing methodologies providing some novel future research directions. Finally, the specific paper can be considered as a starting point for researchers wishing to design cloud‐forensicable services over the cloud. Copyright © 2016 John Wiley & Sons, Ltd.
The Use of Autologous Peritoneum for Complete Caval Replacement Following Resection of Major Intra‐abdominal Malignancies
Authors: Coubeau Laurent , Rico Juri Juan‐Manuel , Ciccarelli Olga , Jabbour Nicolas , Lerut Jan 
Published: November 2016

AbstractObjectiveAssessment of a simple layer peritoneal tube used as an autogenous inferior vena cava replacement.BackgroundExtensive en‐bloc multivisceral resection including major vessels is effective in selected abdominal malignancies, but the need for vascular reconstruction represents a surgical challenge. We describe the use of autologous peritoneum for caval replacement.MethodsAutogenous parietal peritoneum without fascial backing was harvested and tubularized to replace the inferior vena cava (IVC) in four patients with complex abdominal tumors. Surgical morbidity was evaluated using the Clavien–Dindo classification, and graft patency was systematically evaluated with ultrasound.ResultsAll four patients had multiorgan resections for malignancies involving the retro‐hepatic IVC, and they all required the replacement of infrarenal and suprarenal IVC segments. Additionally, all four required a right nephrectomy, two had a combined major hepatectomy, and one patient needed a veno‐venous bypass. All had an R0 resection. A clinical follow‐up took place between 5 and 11 months after surgery for each patient. Four‐month graft patency was confirmed by ultra‐sound and TDM with no sign of disease recurrence.ConclusionsAutologous peritoneum without fascial backing is a good and safe option for circumferential replacement of IVC after extensive en‐bloc tumor resection with IVC involvement.
Why Is Cancer Genetic Counseling Underutilized by Women Identified as at Risk for Hereditary Breast Cancer? Patient Perceptions of Barriers Following a Referral Letter
Authors: Kne Alyssa , Zierhut Heather , Baldinger Shari , Swenson Karen K. , Mink Pamela , Veach Patricia McCarthy , Tsai Michaela L. 
Published: November 2016

AbstractFamily history information comprises an important tool in identifying and referring patients at risk for hereditary breast and ovarian cancer (HBOC) to cancer genetic counseling. Despite recommendations and support provided by numerous professional organizations, cancer genetic counseling services are underutilized by atrisk patients. This study aimed to: (1) determine the rate of genetic counseling utilization following a referral letter, (2) characterize factors (barriers and supports) which influenced uptake of services, and (3) identify potential strategies for increasing utilization. This study evaluated the uptake of cancer genetic counseling among 603 screening mammography patients identified as having an increased risk for HBOC based on National Comprehensive Cancer Network (NCCN) guidelines. At risk individuals and their primary care providers were mailed a referral letter recommending genetic counseling. Three focus groups (N = 24) were conducted to identify responses to receiving a letter recommending genetic counseling, barriers to seeking genetic counseling, and facilitating factors to utilizing these services. Participant responses were qualitatively analyzed using thematic and cross case analysis. Within one year, 50/603 (8 %) of the identified at‐risk women completed a genetic counseling appointment. Participant‐perceived barriers which influenced their decision not to seek genetic counseling included lack of relevance and utility, limited knowledge about genetic counseling, concerns about the genetic counseling process, and concerns about cost and insurance coverage. Participant‐perceived facilitating factors which would support a decision to seek genetic counseling included greater awareness and education about genetic counseling services when receiving a referral, and improved follow up and guidance from their provider. Findings from this study support the need for patient and primary care provider education, and improved provider‐patient communication to increase uptake of genetic counseling services.
Humeral lengthening and deformity correction
Authors: Hosny Gamal Ahmed 
Published: November 2016

Introduction Ilizarov principles and hybrid fixation have improved the results of humeral lengthening. We reviewed the literature on humeral lengthening using different fixators with regard to indications, operative technique, results and complications. We also retrospectively reviewed 56 segments in 46 patients treated with humeral lengthening and deformity correction using Ilizarov external fixation. The etiology was achondroplasia (10 patients), epiphyseal injury (8 cases), infection (11 cases) and Erb's palsy (17 cases). The average age at surgery was 14 years (range 8–20 years). The patients were assessed clinically and radiographically and DASH score was available for 36 segments. Follow-up ranged from 1–11 years. The magnitude of lengthening achieved ranged from 5–15.5 cm with an average of 9 cm. The average healing index was 29.5 cm (range 26–37 days). The percentage of area of lengthening to the original length ranged from 25 to 100% with an average of 55%. The average DASH (available for 36 segments only) score ranged from 15–40 preoperatively to 7–16 ( P = 0.04) at last follow-up. Functionally, all the patients returned to their preoperative jobs and daily activities including sports. Complications Complications included pin track infection in 46 segments, radial nerve palsy which recovered completely in 2 patients, fracture of the regenerate in 7 cases and premature consolidation of the regenerate in one case. Conclusion Humeral lengthening, whether unilateral or bilateral, is a valid method that improves the outcome following arm shortening and deformity correction, including angulation and rotation. Extensive lengthening up to 100% of the original length could be achieved without increasing the risk of complications. Level of evidence IV, retrospective cohort.
A case–control study of risk factors for maternal mortality in Burkina Faso in 2014
Authors: Ouédraogo Adja M. , Ouédraogo Henri G. , Baguiya Adama , Millogo Tieba , Somé Anthony , Kouanda Seni 
Published: November 2016

AbstractObjectiveTo analyze the factors associated with maternal mortality in hospitals in Burkina Faso in the context of emergency obstetric neonatal care.MethodsA case‐control study was conducted in 812 health facilities in the public and private sectors, involving all categories of health facility in the 13 regions of Burkina Faso. The study population included all women with obstetric complications from May 2013 to April 2014. For any identified case of maternal death, a control counterpart (living woman) was matched according to the obstetric complication. Conditional logistic regression was used to assess factors associated with maternal mortality.ResultsThe analysis focused on a total of 1128 women (564 cases and 564 controls). Place of residence (P=0.011), the referral for care (P<0.001), maternal age (P<0.001), state of consciousness of the mother (P<0.001), and the presence of a fever (P<0.001) were significantly associated with the occurrence of maternal death. In multivariate analysis, maternal age (OR 1.45; 95% CI, 0.95–2.20; P<0.001), coma (OR 1.44; 95% CI, 0.16–0.2; P=0.010), and presence of fever (OR 1.67; 95% CI, 1.21–2.28; P<0.001) were risk factors related to maternal death.ConclusionThe determined factors demonstrate that the survival of women is closely linked to their health.
Stakeholder Capability Enhancement as a Path to Promote Human Dignity and Cooperative Advantage
Authors: Westermann-Behaylo Michelle K. , Van Buren Harry J. , Berman Shawn L. 
Published: November 2016

ABSTRACT:Promoting dignity is at the heart of the human capability approach to development. We introduce the concept of stakeholder capability enhancement, beginning with a discussion of the capability approach to development proposed by Sen (1985) and further advanced by Nussbaum (1990) to incorporate notions of dignity. Thereafter follows a review of the literature on value creation stakeholder management and convergent stakeholder theory (Freeman, 1984; Freeman, Harrison, Wicks, Palmer, & DeColle, 2010; Harrison & Wicks, 2013; Jones & Wicks, 1999), as the foundation for our concept of stakeholder capability enhancement. The remainder of this article develops a model that integrates stakeholder management with the human capability approach to detail the cooperative advantage that accrues to business and its stakeholders, as well as the gains in social wellbeing and dignity, when stakeholder capability enhancement becomes a common enterprise strategy. The model also explores the risks and boundary conditions firms face when seeking to profit from stakeholder capability tradeoffs. In explaining the model, we explore normative responsibilities and consequences with regard to human capabilities and dignity. We conclude with implications for future research.
Electronic Clostridium difficile Infection Bundle Reduces Time to Initiation of Contact Precautions
Authors: Dewart Courtney M. , Blanco Natalia , Foxman Betsy , Malani Anurag N. 
Published: November 2016

The impact of computerized order-entry bundles on timing of contact precaution initiation for C. difficile infection (CDI) remains largely unexplored. Implementation of an electronic CDI prevention and management bundle that included an automatic isolation component significantly reduced time to initiation of contact precautions from 33.7 to 22.4 hours.Infect Control Hosp Epidemiol 2016;242–244
Associations between energy density of meals and snacks and overall diet quality and adiposity measures in British children and adolescents: the National Diet and Nutrition Survey
Authors: Murakami Kentaro , Livingstone M. Barbara E. 
Published: November 2016

AbstractThis cross-sectional study examined how energy density (ED) of meals and snacks are associated with overall diet quality and adiposity measures in 1617 British children aged 4–18 years from the 1997 National Diet and Nutrition Survey. On the basis of data from 7-d weighed dietary record, all eating occasions were divided into meals or snacks on the basis of time (meals: 06.00–09.00, 12.00–14.00 and 17.00–20.00 hours; snacks: all others) or contribution to energy intake (EI) (meals: ≥15 %; snacks: <15 %). ED of meals and snacks was calculated on the basis of food only. Overall diet quality was assessed using the Mediterranean diet score (range 0–8). Irrespective of the definition of meals and snacks, ≥67 % of EI was derived from meals, whereas ED of meals was lower than ED of snacks (mean: 8·50–8·75v. 9·69–10·52 kJ/g). Both ED of meals and ED of snacks were inversely associated with total intakes of vegetables, fruits, dietary fibre and overall diet quality and positively associated with total intakes of fat. However, the associations were stronger for ED of meals. The change in the Mediterranean diet score with a 1-unit increase of ED (kJ/g) was −0·35 to −0·30 for ED of meals and −0·09 to −0·06 for ED of snacks (allP<0·0001). After adjustment for potential confounders, all measures of ED of meals and snacks did not show positive associations with adiposity measures. In conclusion, although both ED of meals and ED of snacks were associated with adverse profiles of overall diet quality (but not adiposity measures), stronger associations were observed for ED of meals.
PRESCRIPTION AND EMPIRE FROM JUSTINIAN TO GROTIUS
Authors: CAVANAGH EDWARD 
Published: November 2016

AbstractEuropeans have long justified a right to something or other by invoking ‘prescription’ (that is, the creation of a legal entitlement by the passage of time). Yet for all the importance of prescription in the creation of international geopolitical order, no genealogy of the idea has emerged from historical or legal scholarship. This article will explore the relationship between prescription and empire within private, public, corporate, and ecclesiastical legal contexts. The idea of prescription is then considered within the specific ideological context of European imperialism between 1580 and 1640, when a series of diplomatic disputes and intellectual debates were had in Europe principally regarding maritime navigation and foreign dominion by ‘donation’. The metamorphosis of prescription in legal and political thought from Justinian (483–565) to Hugo Grotius (1583–1645) is therefore explored. Additional colour is given to this intellectual history by contrasting how corporate interests in North America attempted to justify their foreign land holdings in forts, ports, and hinterland by invoking ‘prescription’ during the early stages of colonial expansion. The case will be made for historians of early modern imperialism and international law to take closer notice of the opportunism of those prepared to justify prescription in theory and practice.
Interpreting Anselm's thought about divine justice: dealing with loose ends
Authors: van Vreeswijk Bernard J. D. 
Published: November 2016

AbstractOver the last fifty years studies of Anselm of Canterbury's concept of divine justice have delivered different results. The aim of this article is to present the results of a new comprehensive inquiry, based on the interpretation of key passages about justice in Anselm's theological works. The article argues that Anselm works with three definitions of God's justice. The first is the most traditional: God's justice is his right dealing with good and bad. The second definition follows the Anselmian concept of God: God's justice is his acting according to his being that than which nothing greater can be conceived. The third definition is God's rightness of will, preserved for its own sake. The article concludes that the attempt to show how these three definitions are related to each other brings to light tensions and loose ends in Anselm's works.
How group members contribute to group performance: Evidence from agent-based simulations
Authors: Douven Igor 
Published: November 2016

AbstractThe authors argue that group performance depends on the degree to which group members identify with the group as well as on their degree of differentiation. In this commentary, I discuss results from agent-based simulations, suggesting that group performance depends, at least in part, on features orthogonal to agents' caring about group performance or about how they are perceived by other group members.
Groups need selves, but which selves? Dual selves in groups and the downsides of individuation
Authors: Healey Mark P. 
Published: November 2016

AbstractIt may be true that “groups need selves,” as Baumeister et al. contend. However, certain types of selfhood and too much selfhood can both be detrimental to group functioning. I draw on theory and research on dual selves in work groups and teams to outline boundary conditions to the hypothesis that emphasizing individual selves yields positive effects for groups.