bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptive output feedback control of a bidirectional AC/DC totem‐pole PFC converter for wireless charging of electric vehicles
Authors: Lassioui Abdellah , El Fadil Hassan , Hamed Ahmed Mohamed , Sidina El Jeilani 
Published: October 2024

AbstractThis paper deals with the control problem of a single‐phase bidirectional alternating current/direct current (AC/DC) totem‐pole power factor correction (PFC) converter intended to be used in wireless power transfer (WPT) chargers for electric vehicles (EVs). The converter is operating as a bridgeless boost rectifier with the PFC functionality during grid to vehicle (G2V) mode and as a PFC inverter during vehicle to grid (V2G) mode. Firstly, the operating principle is presented. Secondly, an overall mathematical model governing all the operating modes of the converter is elaborated. Thirdly, due to the nonlinearity of the studied system, a nonlinear controller–based Lyapunov technique is designed to achieve the following control objectives: (i) unity power factor (UPF) during both power transfer modes G2V and V2G, (ii) regulation of the DC‐link voltage, and (iii) asymptotic stability of the closed‐loop system. Further, as the developed control law requires the measurement of all voltages and currents, an adaptive observer–based Kalman‐like technique is designed to estimate all the required signals and parameters. The performances of the proposed output feedback control technique are validated through several simulation scenarios showing that all control objectives are achieved. It should be noted that the use of the Kalman observer reduces the complexity of the systems as it requires only two measurements (grid voltage and current) making it an advantageous solution over existing solutions where three measurements are generally used. Furthermore, due to the low‐pass filtering behavior of the observer and its susceptibility to estimate the converter's parameters, the robustness of the controller and its insensitivity to the parameter uncertainties are greatly improved.
Low Temperature and Rapid Synthesis of Li‐Rich Li(Li0.17Mn0.83)2O4 Spinel Cathodes Derived from Metal‐Organic Frameworks for Lithium‐Ion Batteries
Authors: Li Ang , Wang Ziqi , Yu Meihui , Chang Ze 
Published: October 2024

AbstractLi‐rich spinel materials (Li1+xMn2−xO4) have shown promise for lithium‐ion batteries. Nevertheless, the preparation of Li1+xMn2−xO4 faces significant challenges due to the difficulty in achieving a balance between well‐crystallized phases and stoichiometric chemistry. Moreover, the synthesis process is highly sensitive to calcination temperature and time, making it susceptible to phase transformations. Therefore, the rational selection of precursors and corresponding calcination procedures is absolutely essential. Herein, we make full use of the nature of metal‐organic frameworks (MOFs) to achieve phase‐controlled synthesis of Li(Li0.17Mn0.83)2O4 (LMO−F) spinel cathodes in 8 minutes at 500 °C. The composition and structural evolution during the pyrolysis process were systematically investigated to clarify the relationship between precursors and derivatives. Notably, the LMO−F achieved good electrochemical performance with 100.4 mAh g−1 at 50 mA g−1 after 100 cycles.
Using rhamnolipid as a promoter to improve the production of germacrene A by Yarrowia lipolytica
Authors: Cui Wenxing , Lin Haohong , Peng Yujia , Qian Xiujuan , Dong Weiliang , Jiang Min 
Published: October 2024

AbstractSignificant progress has recently been made in the biosynthesis of germacrene A using microbial cell factories. Germacrene A is a crucial precursor for the synthesis of anti‐cancer active compounds. However, its hydrophobic characteristics lead to its aggregation in cell membranes and cause severe cytotoxicity. In the present study, we found that rhamnolipids (RLs), as toxicity antidotes, could promote the production of germacrene A. An optimal RLs concentration of 1.25 g L−1 resulted in an increase of over 30% in the germacrene A titer at both shake flask and bioreactor scales. Mechanistic analysis showed that the addition of RLs could dramatically reduce aqueous‐phase surface tension and cell surface hydrophobicity (CSH), and increase the cell membrane permeability. This, in turn, promoted an efficient transfer of germacrene A from cell membrane to extraction phases. The addition of RLs also increased the adenosine triphosphate (ATP) concentration and the nicotinamide adenine dinucleotide (NAD+/NADH) ratio, while reducing reactive oxygen species (ROS) levels. Correspondingly, gene transcripts for key enzymes associated with germacrene A biosynthesis, the respiratory chain, and ROS scavenging were upregulated significantly. This study provides an effective RLs‐regulated fermentation method for the biosynthesis of hydrophobic natural products.
Einfluss rapider Wärmebehandlung auf das kurzzeitige Kriechen von hochfestem Beton
Authors: Rose Jannis , Forman Patrick , Mark Peter 
Published: October 2024

AbstractDer Zusammenbau modularer Tragwerke erfordert eine hohe geometrische Präzision in seinen Betonfertigteilen. Neben Fertigungstoleranzen müssen dabei auch transiente, materialbedingte Abweichungen infolge von Schwinden und Kriechen beachtet werden. Für die Schwindverformungen wurde bereits in [1] gezeigt, dass eine rapide Wärmebehandlung bei Hochleistungsbetonen das Schwinden maßgeblich reduziert. In diesem Beitrag soll der Einfluss der Wärmebehandlung auf die Kriechverformung untersucht werden. Fokus liegt auf dem kurzzeitigen Kriechen innerhalb der ersten 28 d nach Betonage, um frühe Bauzustände experimentell abzubilden. Untersucht werden Wärmebehandlungsdauern von 2, 4 und 24 h bei 80 °C und 60 % RH direkt nach der Betonage sowie Proben ohne Wärmebehandlung als Referenz. Belastungsbeginn ist 48 Stunden nach Betonage, um minimale Zeiten zwischen Herstellung und Montage zu erfassen. Die Experimente erfolgen an zylindrischen Probekörpern (D/H=100/200 mm) und Belastungsgraden von 20 und 40 % der frühen Betonfestigkeit. Es zeigt sich, dass durch die Wärmebehandlung die Kriechdehnungen effektiv reduziert werden, und zwar affin zur Dauer um bis zu 66 % (24 h) bzw. 21 % (2 h). Trotz der hohen Anfangsfestigkeit des Betons zeigt sich auch nichtlineares Kriechen. Die Untersuchungsergebnisse werden für verschiedene Wärmebehandlungsdauern und Belastungsgrößen verallgemeinert und zu funktionalen Zusammenhängen polynomialer Antwortflächen aufgearbeitet.
Analysis of Two Oncological Drugs Futibatinib and Capivasertib via Ion‐Pairing With Eosin Y as a Spectrofluorimetric and Spectrophotometric Probe
Authors: Salem Hesham , Emad Nadeen , El‐Araby Manar , Samir Basmala , Abdelaziz Amany 
Published: October 2024

ABSTRACTUsing spectroscopy, two quick and sensitive analytical methods based on eosin Y ion pairing were developed and assessed in order to determine capivasertib and futibatinib with high selectivity and sensitivity. The quenching impact of futibatinib or capivasertib on the eosin Y's fluorescence at a pH 3.8 and 3.3 for futibatinib and capivasertib, respectively, in 0.1‐M acetate buffer solution was observed using two spectrofluorometric techniques. These techniques are regarded as the original spectrofluorometric techniques for the assay of futibatinib and capivasertib. For futibatinib and capivasertib, the quenching effect on fluorescence was ranged from 100 to 1000 and 150 to 1500 ng mL−1, respectively. The absorbance of the generated ion‐pair was measured using two different spectrophotometric methods at 550 nm in aqueous buffered solutions with pH values of 3.8 and 3.3 for futibatinib and capivasertib, respectively. In the concentration range of 1.0–10.0 and 2.0–10.0 μg mL−1, Beer's law was followed. The four approaches were applied to the analysis of dosage forms with a high percent recovery successfully, and they were assessed in compliance with ICH guidelines.
Barriers and facilitators of healthcare professionals in integrating shared decision‐making in pancreatic cancer treatment: A network approach
Authors: van Broekhoven Joannes Franciscus Adrianus Gerardus , van Heesch Fleur Arda Servasa , Mulder Sasja , Hermens Rosella , van der Wees Philip , van der Kolk Marion 
Published: October 2024

AbstractPurposeShared decision‐making (SDM) is crucial in pancreatic cancer treatment due to its choice‐sensitive nature and limited prognosis. Treatment of pancreatic cancer is organized in a network approach. Several obstacles exist on different levels—patient, healthcare professional, organizational, societal—that impede integration of SDM. This study aims to identify barriers and facilitators to SDM implementation within a comprehensive cancer network.MethodsA qualitative research design was applied, involving interviews and focus groups on barriers and facilitators with healthcare professionals involved in the implementation of SDM. In one comprehensive cancer network in the Netherlands, including seven hospitals, a project was initiated with the goal of empowering patients and healthcare professionals in SDM throughout primary, secondary and tertiary healthcare settings. A total of 17 participants were assessed. Directed qualitative content analysis was performed by two researchers.ResultsMain findings revealed barriers such as time constraints, lack of priority of physicians, little involvement of general practitioners, and insufficient social context of patients in referrals, alongside facilitators including learning communities with practical SDM examples, metro mapping, involvement of case manager in implementation and patient empowerment strategies.ConclusionAddressing cultural, systemic barriers and developing innovative strategies are of importance to enhance SDM in pancreatic cancer treatment in a network approach. This study provides understanding of SDM implementation in complex healthcare settings and offers valuable guidance for future interventions seeking to improve decision‐making processes in pancreatic cancer treatment and beyond.
The Anti‐Cancer Stem Cell Properties of Copper(II)‐Terpyridine Complexes with Attached Salicylaldehyde Moieties
Authors: Singh Karampal , Northcote‐Smith Joshua , Feng Xiao , Singh Kuldip , Suntharalingam Kogularamanan 
Published: October 2024

AbstractWe report the synthesis, characterisation, and anti‐breast cancer stem cell (CSC) properties of two copper(II)‐terpyridine complexes with bidentate salicylaldehyde moieties (2‐hydroxybenzaldehyde for 1 and 2‐hydroxy‐1‐naphthaldehyde for 2). The copper(II)‐terpyridine complexes 1 and 2 are stable in biologically relevant aqueous solutions and display micromolar potency towards breast CSCs. The most effective complex 1 is 5‐fold and 6.6‐fold more potent towards breast CSCs than salinomycin and cisplatin, respectively. The copper(II)‐terpyridine complexes 1 and 2 also decrease the formation and viability of three‐dimensionally cultured mammospheres within the micromolar range. Notably complex 1 is up to 7‐fold more potent towards mammospheres than salinomycin or cisplatin. Mechanistic studies suggest that the copper(II)‐terpyridine complexes 1 and 2 are able to readily enter breast CSCs, elevate intracellular reactive oxygen species levels, induce DNA damage (presumably by oxidative DNA cleavage), and evoke apoptosis that is independent of caspases. This study shows that the copper(II)‐terpyridine motif is a useful building block for the design of anti‐breast CSC agents and reinforces the therapeutic potential of copper coordination complexes.
The Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer (CISTO) study: Lessons learned about management and patient enrollment in a large, pragmatic, patient‐centered trial
Authors: Nathan Krupa K. , Follmer Kristin M. , Nash Michael G. , Wolff Erika M. , Lee Jenney R. , Mecham Solange , Yano Marielle , Kim Sung Min , Comstock Bryan A. , Gore John L. , Smith Angela B. 
Published: October 2024

AbstractBackgroundThe growth of patient and public involvement in clinical research highlights the paucity of literature on operational practices that ensure the success of large, patient‐centered outcomes trials. The authors' objective was to identify tools launched by the Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer (CISTO) study team to determine their effectiveness in maximizing patient enrollment in this observational, pragmatic trial.MethodsThe primary outcomes for this study were patient screening and enrollment across 36 CISTO study sites. The operational strategies included CISTOquestion email correspondence and All Sites Meetings, specifically poll performance data from meetings, and a nonanonymized feedback survey about the CISTO study's management practices. Effectiveness was measured using correlation analysis with patient cohort data, including screenings, enrollments, post‐hoc exclusions, and the post‐hoc exclusion rate.ResultsAverage screenings and enrollment rose after the implementation of CISTOquestion in April 2021, with the average number of screenings rising from 7.42 to 26.8 patients per month and enrollment rising from 3.76 to 16 patients per month. Use of CISTOquestion was correlated strongly with increased patient screenings and enrollment across all study sites. Eighty‐three percent of sites with above‐average post‐hoc exclusion rates (≥0.092) sent below the average number of CISTOquestion inquiries. Poll performance and survey data revealed that all survey respondents who used CISTOquestion found that it was a valuable and accessible resource.ConclusionsOf the several operational tools implemented within the CISTO study that aimed to improve patient enrollment, CISTOquestion, a centralized email for addressing eligibility questions, was most beneficial to overall patient accrual.
Polymer‐Assisted Nucleation for Stable Single‐Crystal Perovskite Thin Films
Authors: Xi Jiangyue , Zhao Guoxiang , Sun Xiangle , Zhang Sihan , Du Xinyu , Li Jiating , Yang Huan , Wang Ruonan , Lu Zheng , Zou Guifu 
Published: October 2024

AbstractOrganic‐inorganic hybrid perovskite single crystals have emerged as a strong candidate in photovoltaic and general optoelectronic applications. However, the high supersaturation of the precursor solution leads to the rapid formation of a significant number of nuclei and a diminished concentration of perovskite solute. Consequently, the inadequate availability of precursors poses challenges in sustaining the subsequent crystal growth phase, culminating in the development of small‐sized single crystals. In this work, we report a controlled nucleation process to foster the growth of large‐size single crystals. This method through the coordination interaction between polyacrylic acid and Pb2+ ions, and substitution of the coordination with I− ions. This reduces the formation of the Pb‐I6 complex, which promptly emerges in a state of supersaturation and acts as a nucleus, thereby effectively reducing the number of nuclei formed. The single crystals produced using this method exhibit a lateral size exceeding 5 mm, an extended absorption range, a longer carrier lifetime of 10.93 ns, and enhanced stability. These crystals demonstrate the ability to remain stable even after storage in an ambient environment (T=20±5 °C, RH=60±5 %) for a period of 20 days.
FIELDimagePy: A tool to estimate zonal statistics from an image, bounded by one or multiple polygons
Authors: Chatterjee Sumantra , Murray Seth C. , Matias Filipe Inácio , Fahlgren Noah 
Published: October 2024

AbstractVegetation indices have become an indispensable tool in remote sensing‐based agricultural research. A recent area of advancement in agricultural remote sensing research is in high‐throughput phenotyping, often conducted on a plot by plot basis. FIELDimageR is a tool used extensively in high‐throughput phenotyping that estimates zonal statistics of vegetation indices per plot. However, being written in R language, FIELDimageR requires high computing time. As a high‐resolution image over a large area means a large number of pixels, FIELDimageR is incapable of using high‐resolution orthomosaicked images without reducing image resolution by aggregating digital numbers of several pixels and treating them as one pixel. This research tool implements FIELDimageR in the Python language as FIELDimagePy. FIELDimagePy follows similar workflows as FIELDimageR and generates equivalent results for zonal statistics of vegetation indices per plot. FIELDimagePy is significantly and substantially faster than FIELDimageR. Computing time by FIELDimagePy are three to four times lower than computing times by FIELDimageR, even when using raw images with 16 times denser pixels. Moreover, FIELDimagePy is useful beyond plot by plot research in agriculture and capable of estimating zonal statistics of any raster bounded by any polygons. With slight modifications, FIELDimagePy can be useful for other disciplines of science, such as geophysics, geography, economics, medical sciences, among others. FIELDimagePy can be accessed from the GitHub repository: https://github.com/SumantraChatterjee/FIELDimagePy.
A novel puzzle ring replacement technique of a lumen‐apposing metal stent with a double‐pigtail plastic stent to prevent walled‐off necrosis recurrence (with video)
Authors: Mukai Shuntaro , Sofuni Atsushi , Tsuchiya Takayoshi , Tanaka Reina , Tonozuka Ryosuke , Yamamoto Kenjiro , Matsunami Yukitoshi , Nagai Kazumasa , Kojima Hiroyuki , Minami Hirohito , Asano Kyoko , Itoi Takao 
Published: October 2024

AbstractReplacing a lumen‐apposing metal stent (LAMS) with a double‐pigtail plastic stent (DPS) after treatment for walled‐off necrosis contributes to the prevention of recurrence. However, the success rate is not very high. To overcome this issue, we devised a novel stent‐replacement technique. In the final treatment procedure, a 7‐F DPS was placed in the lumen of the LAMS. Subsequently, the walled‐off necrosis shrank, and granulation formed over the pigtail portion, which fixed the DPS. The LAMS alone was removed with grasping forceps, leaving the DPS in the lumen of the LAMS (i.e., a puzzle‐ring technique; direct or rotary removal technique). Between August 2021 and August 2023, 18 patients were evaluated for recurrence prevention using this novel technique (median duration of LAMS placement, 37 days). In 17 patients (94.4%), the LAMS was successfully replaced with a 7‐F DPS (direct technique 14, rotary technique 3; median removal procedure time, 3 min). No recurrence was observed during the median observation period of 385 days. Before using this technique (April 2012 to August 2022), the technical success rate of replacement of LAMS with 7‐F DPS was significantly lower (61.8% [42/68, p = 0.02]). Recurrence of pancreatic fluid collection occurred in 15.3% (4/26) of the patients who could not undergo replacement with a 7‐F DPS. The novel puzzle ring technique, which improves the success rate of LAMS for DPS replacement, may be useful in reducing recurrence after walled‐off necrosis treatment.
Disruption of natural disturbance regime decouples habitat and life stage in a keystone species
Authors: Merz Joseph E. , Brown Rocko A. , Sellheim Kirsten , Zeug Steven C. 
Published: October 2024

AbstractAnthropogenic disturbance of stream ecosystems, often chronic in nature, has been studied extensively. However, when disturbance is driven by more than one resource policy over many decades, feedback between habitat evolution and biological adaptation can be disrupted and ecological function affected in unforeseen ways. We analyzed over 100 years of Chinook salmon (Oncorhynchus tshawytscha) length frequency trends associated with fisheries management and changes in available spawning substrate (habitat) linked to flow regulation in a highly altered California river. Over time, salmon lengths generally decreased, fluctuating with exploitation (ocean harvest) and hatchery production rates. Female size reduction, coupled with a degrading and coarsening channel, and perching peripheral habitat related to past mining activity, indicates available spawning substrate may be too large to support the current salmon population. Assuming a salmon can move material ~10% of her body length, length frequency data and current substrate size distribution suggest that increasing salmon sizes to historic distributions could increase available spawning habitat by as much as 13%. Alternatively, decreasing spawning substrate size could support a greater portion of the current population. To test the latter hypothesis and inform future management actions, we monitored two spawning riffles where large and small gravel was placed on top of a cobble. We observed an immediate spawning activity increase that was more pronounced where smaller gravel was deposited. Following a decade of habitat decline, the two sites were both replenished with medium gravel. Elevated spawning use occurred immediately at both sites, commensurate with this intermediate size, further supporting our hypotheses. Sediment coarsening and habitat disconnect below dams, combined with reduced salmon size, indicate the natural spawning process may be decoupled from available habitat below dams in the foreseeable future without continuous intervention. Actively managing salmon population demographics through modified hatchery and size‐selective harvest practices and developing a coarse sediment budget with size‐appropriate material for regulated anadromous rivers could produce immediate benefits for ecosystem services, including salmon populations. However, these management actions will require continued maintenance and informed socio‐ecological goals to remain successful.
Do leaf traits shape herbivory in tropical montane rainforests? A multispecies approach
Authors: Schön Jana E. , Keuth Raya , Homeier Jürgen , Limberger Oliver , Bendix Jörg , Farwig Nina , Brandl Roland 
Published: October 2024

AbstractThe co‐evolutionary arms race between herbivores and plants forces plants to evolve protection strategies that reduce the palatability of the plant modules attacked by the herbivores. These characteristics of traits have consequences for both the survival of plant individuals and the composition of plant communities. Thus, correlating traits of for instance leaves with herbivory is an important step toward understanding the dynamics of plant populations and communities. Traits can either be measured using conventional lab methods or recently developed spectral sensing techniques. We examined whether leaf traits of trees are related to herbivory in a multispecies approach. Furthermore, we explored whether leaf traits characterized by spectral sensing provide similar relations to herbivory as lab‐based leaf traits. We established nine 1‐ha square plots evenly distributed over three different forest types in Ecuadorian tropical montane rainforests where we estimated herbivory as the leaf area loss (in square centimeters) of 20 (±5) leaves sampled from the canopies of 380 tree individuals belonging to 51 tree species (7 ± 1 individuals/species) using lab‐ and spectral‐sensing‐based methods. For each methodological approach, we ran 100 linear mixed‐effects models with all respective leaf traits as predictor and herbivory as response variables for data subsets containing one randomly selected tree individual of each species to estimate the range of the regression coefficients for each trait. Automated stepwise backward selections determined the frequency of each trait having an important influence on herbivory. We found no clear relations between leaf traits and herbivory for neither lab‐ nor spectral‐sensing‐based traits. A nested variance component analysis demonstrated that the observed variability was mainly due to the variation in trait concentrations between tree individuals of a species. Our results suggest that snapshot data lead to a mismatch between herbivory and the concentrations of traits during the peak of herbivory. Another explanation could be that environmental conditions or processes along the food web are more important in structuring herbivory than leaf traits.