bluuebunny/crossref_metadata_2025_split huggingface dataset:
Making multiple requests in French and Finnish convenience stores
Authors: Mondada Lorenza , Sorjonen Marja-Leena 
Published: December 2016

AbstractThis article systematically explores the sequential contexts for making multiple requests during shop encounters. Based on video recordings in convenience stores in France and Finland, it describes the multimodal practices that buyers and sellers use to treat multiple requests as progressively building a global buying project. The purpose of this study is to demonstrate how multiple requests can be packed together, as relatively simple actions achieved simultaneously or successively in embodied and verbal ways either as subsequent contiguous sequences of actions, or as sequences of actions separated by inserted actions. This article also examines how requests are tied together, and how ‘late’ requests are fitted to the last sequential opportunities in the unfolding encounter. This analysis contributes to the study of commercial encounters and the buying process, as well as to the understanding of sequence organization. It likewise contributes to comparative analyses by discussing the similarities and specificities of this activity across cultural contexts and in different time periods. (Requests, shop encounters, social interaction, multimodality, French, Finnish)
Content encapsulation in consciousness is likely to be incomplete
Authors: Basso Demis 
Published: December 2016

AbstractAlthough the passive frame theory (PST) seems to be very plausible, the encapsulation of content generation deserves further elaboration. Many concepts and data considering the capacity theory, perception, and higher cognitive processes seem to contradict this principle. In general, PST can be suitable in many cases, but it needs to be completed by other mechanisms.
What if consciousness has no function?
Authors: Blackmore Susan 
Published: December 2016

AbstractAn implicitly dualist or Cartesian materialist theory of consciousness is proposed without citing the many well-known problems with such theories. A function for consciousness is proposed with no reference to the possibility that “consciousness itself” has no function of its own. The theory builds on proposed “subset consensus” and “integration consensus” when in the literature there is no such consensus on these issues.
At what timescale does consciousness operate?
Authors: Hommel Bernhard , Wiers Reinout W. 
Published: December 2016

AbstractWhile applauding Morsella et al. for linking consciousness to action control, we ask what their theory implies regarding the exact functionality of consciousness and the timescale at which it operates. Does consciousness operate on, and resolve the conflict it emerges from (despite its slowness), or does it operate on future conflicts that it might resolve by externalizing/socializing cognitive control?
Locating consciousness: We are conflicted by the role of conflict
Authors: Massaro Dom , Rowe Bill 
Published: December 2016

AbstractWhat is consciousness for? Consciousness allows us to handle conflict, a promising proposal by Morsella et al. However, they provide little evidence as to why consciousness is particularly valuable in resolving conflict, nor do they limit the role of consciousness to only conflicting experiences. We attempt to clarify their possible positions and offer several solutions for how these might be formulated and tested.
Origins of emotional consciousness
Authors: Melo Hans L. , Koscik Timothy R. , Vrantsidis Thalia H. , Hathaway Georgia , Cunningham William A. 
Published: December 2016

AbstractWhile the field of emotions research has benefited from new developments in neuroscience, many theoretical questions remain unsolved. We propose that integrating our iterative reprocessing (IR) framework with the passive frame theory (PFT) may help unify competing theoretical perspectives of emotion. Specifically, we propose that PFT and the IR framework offer a point of origin for emotional experience.
Action-based synthesis of parental brain consciousness
Authors: Swain James E. , Caluser Ilinca , Mahmood Zainab , Meldrim Madalyn , Morelen Diana 
Published: December 2016

AbstractParenting consciousness, in line with passive frame theory, may be considered inseparable from action. With combined brain-imaging and cognitive-behavioral analyses, we are in the early phases of understanding how parental brain circuits regulate parental thoughts and behavior. Furthermore, work on parental consciousness confirms the importance of motor outputs and outlines related circuits that inform consciousness across generations.
Effect of the axial magnetic field on coexisting stimulated Raman and Brillouin scattering of a circularly polarized beam
Authors: Vyas Ashish , Sharma Swati , Singh Ram Kishor , Sharma R.P. 
Published: December 2016

AbstractThis paper presents a model to study the two prominent coexisting instabilities, stimulated Raman (SRS), and stimulated Brillouin scattering (SBS) in the presence of background axial magnetic field. In the context of laser-produced plasmas, this model is very useful in the situations where a self-generated axial magnetic field is present as well as where an external axial magnetic field is applied. Due to the interplay between both the scattering processes, the behavior of one scattering process is greatly modified in the presence of another coexisting scattering process. The impact of this coexisting phenomenon and axial magnetic field on the back reflectivity of scattered beams has been explored. It has been demonstrated that the back reflectivity gets modified significantly due to the coexistence of both the scattering processes (SRS and SBS) as well as due to the axial magnetic field. Results are also compared with the three-wave interaction case (isolated SRS or SBS case).
Sketching in three dimensions: A beautification scheme
Authors: Shankar Sree , Rai Rahul 
Published: December 2016

AbstractPrimary among all the activities involved in conceptual design is freehand sketching. There have been significant efforts in recent years to enable digital design methods that leverage humans’ sketching skills. Conventional sketch-based digital interfaces are built on two-dimensional touch-based devices like sketchers and drawing pads. The transition from two-dimensional to three-dimensional (3-D) digital sketch interfaces represents the latest trend in developing new interfaces that embody intuitiveness and human–human interaction characteristics. In this paper, we outline a novel screenless 3-D sketching system. The system uses a noncontact depth-sensing RGB-D camera for user input. Only depth information (no RGB information) is used in the framework. The system tracks the user's palm during the sketching process and converts the data into a 3-D sketch. As the generated data is noisy, making sense of what is sketched is facilitated through a beautification process that is suited to 3-D sketches. To evaluate the performance of the system and the beautification scheme, user studies were performed on multiple participants for both single-stroke and multistroke sketching scenarios.
Pilot study to harmonize the reported influenza intensity levels within the Spanish Influenza Sentinel Surveillance System (SISSS) using the Moving Epidemic Method (MEM)
Authors: BANGERT M. , GIL H. , OLIVA J. , DELGADO C. , VEGA T. , DE MATEO S. , LARRAURI A. ,   the Epidemiology Working Group of the Spanish Influenza Sentinel Surveillance System
Published: December 2016

SUMMARYThe intensity of annual Spanish influenza activity is currently estimated from historical data of the Spanish Influenza Sentinel Surveillance System (SISSS) using qualitative indicators from the European Influenza Surveillance Network. However, these indicators are subjective, based on qualitative comparison with historical data of influenza-like illness rates. This pilot study assesses the implementation of Moving Epidemic Method (MEM) intensity levels during the 2014–2015 influenza season within the 17 sentinel networks covered by SISSS, comparing them to historically reported indicators. Intensity levels reported and those obtained with MEM at the epidemic peak of the influenza wave, and at national and regional levels did not show statistical difference (P = 0·74, Wilcoxon signed-rank test), suggesting that the implementation of MEM would have limited disrupting effects on the dynamic of notification within the surveillance system. MEM allows objective influenza surveillance monitoring and standardization of criteria for comparing the intensity of influenza epidemics in regions in Spain. Following this pilot study, MEM has been adopted to harmonize the reporting of intensity levels of influenza activity in Spain, starting in the 2015–2016 season.
The future of social care funding: who pays?
Authors: Kenny T. , Barnfield J. , Daly L. , Dunn A. , Passey D. , Rickayzen B. , Teow A. 
Published: December 2016

AbstractWith the UK population ageing, deciding upon a satisfactory and sustainable system for the funding of people’s long-term care (LTC) needs has long been a topic of political debate. Phase 1 of the Care Act 2014 (“the Act”) brought in some of the reforms recommended by the Dilnot Commission in 2011. However, the Government announced during 2015 that Phase 2 of “the Act” such as the introduction of a £72,000 cap on Local Authority care costs and a change in the means testing thresholds1 would be deferred until 2020. In addition to this delay, the “freedom and choice” agenda for pensions has come into force. It is therefore timely that the potential market responses to help people pay for their care within the new pensions environment should be considered. In this paper, we analyse whether the proposed reforms meet the policy intention of protecting people from catastrophic care costs, whilst facilitating individual understanding of their potential care funding requirements. In particular, we review a number of financial products and ascertain the extent to which such products might help individuals to fund the LTC costs for which they would be responsible for meeting. We also produce case studies to demonstrate the complexities of the care funding system. Finally, we review the potential impact on incentives for individuals to save for care costs under the proposed new means testing thresholds and compare these with the current thresholds. We conclude that:∙Although it is still too early to understand exactly how individuals will respond to the pensions freedom and choice agenda, there are a number of financial products that might complement the new flexibilities and help people make provision for care costs.∙The new care funding system is complex making it difficult for people to understand their potential care costs.∙The current means testing system causes a disincentive to save. The new means testing thresholds provide a greater level of reward for savers than the existing thresholds and therefore may increase the level of saving for care; however, the new thresholds could still act as a barrier since disincentives still exist.
Finding peace in clinical settings: A narrative review of concept and practice
Authors: Austin Philip , MacLeod Roderick 
Published: December 2016

ABSTRACTThe purpose of this review was to investigate and review the concept of “peace” and the role it plays in the spiritual well-being and care of people with a chronic or terminal illness. Our objectives were, first, to examine the importance of peace in palliative care as a measure of acceptance and in chronic illness settings as a predictor of improved survival. Second, we explored the dimensions of peace and their relationships with spiritual well-being. We further examined how the constructs of peace are assessed both within valid spiritual well-being measures and as individual items related solely to peace. Finally, we examined therapies aimed at promoting peace and emotional well-being in palliative and chronic illness settings. Despite much being written about different constructs of peace and the positive effects of being at peace during times of illness, the effects of therapies on the feeling of peace are not well-studied.
The relevance of uncertainty and goal conflict to mental disorders, their prevention and management: a unifying approach
Authors: Einstein Danielle A. , Mansell Warren 
Published: December 2016

AbstractIntolerance of Uncertainty (IU) has been shown to underlie a range of disorders. Technological advances have produced a decline in our development of an ability to wait in the face of uncertainty. The paper provides an update on empirical, theoretical and neural research in IU. Einstein's extended trandiagnostic model of IU is described. This model is based on control theory. The research update and IU model propose specific tools which can be implemented within transdiagnostic treatment approaches.
Education and Intelligence: Pity the Poor Teacher because Student Characteristics are more Significant than Teachers or Schools
Authors: Detterman Douglas K. 
Published: December 2016

AbstractEducation has not changed from the beginning of recorded history. The problem is that focus has been on schools and teachers and not students. Here is a simple thought experiment with two conditions: 1) 50 teachers are assigned by their teaching quality to randomly composed classes of 20 students, 2) 50 classes of 20 each are composed by selecting the most able students to fill each class in order and teachers are assigned randomly to classes. In condition 1, teaching ability of each teacher and in condition 2, mean ability level of students in each class is correlated with average gain over the course of instruction. Educational gain will be best predicted by student abilities (up tor= 0.95) and much less by teachers’ skill (up tor= 0.32). I argue that seemingly immutable education will not change until we fully understand students and particularly human intelligence. Over the last 50 years in developed countries, evidence has accumulated that only about 10% of school achievement can be attributed to schools and teachers while the remaining 90% is due to characteristics associated with students. Teachers account for from 1% to 7% of total variance at every level of education. For students, intelligence accounts for much of the 90% of variance associated with learning gains. This evidence is reviewed.
Advances in the Neuroscience of Intelligence: from Brain Connectivity to Brain Perturbation
Authors: Santarnecchi Emiliano , Rossi Simone 
Published: December 2016

AbstractOur view is that intelligence, as expression of the complexity of the human brain and of its evolutionary path, represents an intriguing example of “system level brain plasticity”: tangible proofs of this assertion lie in the strong links intelligence has with vital brain capacities as information processing (i.e., pure, rough capacity to transfer information in an efficient way), resilience (i.e., the ability to cope with loss of efficiency and/or loss of physical elements in a network) and adaptability (i.e., being able to efficiently rearrange its dynamics in response to environmental demands). Current evidence supporting this view move from theoretical models correlating intelligence and individual response to systematic “lesions” of brain connectivity, as well as from the field of Noninvasive Brain Stimulation (NiBS). Perturbation-based approaches based on techniques as transcranial magnetic stimulation (TMS) and transcranial alternating current stimulation (tACS), are opening newin vivoscenarios which could allow to disclose more causal relationship between intelligence and brain plasticity, overcoming the limitations of brain-behavior correlational evidence
Emotional Responses to Disturbing Political News: The Role of Personality
Authors: Ryan Timothy J. , Wells Matthew S. , Acree Brice D. L. 
Published: December 2016

AbstractRecent scholarship in political science identifies emotions as an important antecedent to political behavior. Existing work, however, has focused much more on the political effects of emotions than on their causes. Here, we begin to examine how personality moderates emotional responses to political events. We hypothesized that the personality trait need for affect (NFA) would moderate the emotions evoked by disturbing political news. Drawing data from a survey experiment conducted on a national sample, we find that individuals high in NFA have an especially vivid emotional response to disturbing news—a moderating relationship that has the potential to surpass those associated with symbolic attachments.
HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression
Authors: Guha Manti , Srinivasan Satish , Guja Kip , Mejia Edison , Garcia-Diaz Miguel , Johnson F Brad , Ruthel Gordon , Kaufman Brett A , Rappaport Eric F , Glineburg M Rebecca , Fang Ji-Kang , Szanto Andres Klein , Nakagawa Hiroshi , Basha Jeelan , Kundu Tapas , Avadhani Narayan G 
Published: December 2016

AbstractReduced mitochondrial DNA copy number, mitochondrial DNA mutations or disruption of electron transfer chain complexes induce mitochondria-to-nucleus retrograde signaling, which induces global change in nuclear gene expression ultimately contributing to various human pathologies including cancer. Recent studies suggest that these mitochondrial changes cause transcriptional reprogramming of nuclear genes although the mechanism of this cross talk remains unclear. Here, we provide evidence that mitochondria-to-nucleus retrograde signaling regulates chromatin acetylation and alters nuclear gene expression through the heterogeneous ribonucleoprotein A2 (hnRNAP2). These processes are reversed when mitochondrial DNA content is restored to near normal cell levels. We show that the mitochondrial stress-induced transcription coactivator hnRNAP2 acetylates Lys 8 of H4 through an intrinsic histone lysine acetyltransferase (KAT) activity with Arg 48 and Arg 50 of hnRNAP2 being essential for acetyl-CoA binding and acetyltransferase activity. H4K8 acetylation at the mitochondrial stress-responsive promoters by hnRNAP2 is essential for transcriptional activation. We found that the previously described mitochondria-to-nucleus retrograde signaling-mediated transformation of C2C12 cells caused an increased expression of genes involved in various oncogenic processes, which is retarded in hnRNAP2 silenced or hnRNAP2 KAT mutant cells. Taken together, these data show that altered gene expression by mitochondria-to-nucleus retrograde signaling involves a novel hnRNAP2-dependent epigenetic mechanism that may have a role in cancer and other pathologies.
Defining functional interactions during biogenesis of epithelial junctions
Authors: Erasmus J. C. , Bruche S. , Pizarro L. , Maimari N. , Poggioli T. , Tomlinson C. , Lees J. , Zalivina I. , Wheeler A. , Alberts A. , Russo A. , Braga V. M. M. 
Published: December 2016

AbstractIn spite of extensive recent progress, a comprehensive understanding of how actin cytoskeleton remodelling supports stable junctions remains to be established. Here we design a platform that integrates actin functions with optimized phenotypic clustering and identify new cytoskeletal proteins, their functional hierarchy and pathways that modulate E-cadherin adhesion. Depletion of EEF1A, an actin bundling protein, increases E-cadherin levels at junctions without a corresponding reinforcement of cell–cell contacts. This unexpected result reflects a more dynamic and mobile junctional actin in EEF1A-depleted cells. A partner for EEF1A in cadherin contact maintenance is the formin DIAPH2, which interacts with EEF1A. In contrast, depletion of either the endocytic regulator TRIP10 or the Rho GTPase activator VAV2 reduces E-cadherin levels at junctions. TRIP10 binds to and requires VAV2 function for its junctional localization. Overall, we present new conceptual insights on junction stabilization, which integrate known and novel pathways with impact for epithelial morphogenesis, homeostasis and diseases.
Blood flow controls bone vascular function and osteogenesis
Authors: Ramasamy Saravana K. , Kusumbe Anjali P. , Schiller Maria , Zeuschner Dagmar , Bixel M. Gabriele , Milia Carlo , Gamrekelashvili Jaba , Limbourg Anne , Medvinsky Alexander , Santoro Massimo M. , Limbourg Florian P. , Adams Ralf H. 
Published: December 2016

AbstractWhile blood vessels play important roles in bone homeostasis and repair, fundamental aspects of vascular function in the skeletal system remain poorly understood. Here we show that the long bone vasculature generates a peculiar flow pattern, which is important for proper angiogenesis. Intravital imaging reveals that vessel growth in murine long bone involves the extension and anastomotic fusion of endothelial buds. Impaired blood flow leads to defective angiogenesis and osteogenesis, and downregulation of Notch signalling in endothelial cells. In aged mice, skeletal blood flow and endothelial Notch activity are also reduced leading to decreased angiogenesis and osteogenesis, which is reverted by genetic reactivation of Notch. Blood flow and angiogenesis in aged mice are also enhanced on administration of bisphosphonate, a class of drugs frequently used for the treatment of osteoporosis. We propose that blood flow and endothelial Notch signalling are key factors controlling ageing processes in the skeletal system.
Generation of internal solitary waves by frontally forced intrusions in geophysical flows
Authors: Bourgault Daniel , Galbraith Peter S. , Chavanne Cédric 
Published: December 2016

AbstractInternal solitary waves are hump-shaped, large-amplitude waves that are physically analogous to surface waves except that they propagate within the fluid, along density steps that typically characterize the layered vertical structure of lakes, oceans and the atmosphere. As do surface waves, internal solitary waves may overturn and break, and the process is thought to provide a globally significant source of turbulent mixing and energy dissipation. Although commonly observed in geophysical fluids, the origins of internal solitary waves remain unclear. Here we report a rarely observed natural case of the birth of internal solitary waves from a frontally forced interfacial gravity current intruding into a two-layer and vertically sheared background environment. The results of the analysis carried out suggest that fronts may represent additional and unexpected sources of internal solitary waves in regions of lakes, oceans and atmospheres that are dynamically similar to the situation examined here in the Saguenay Fjord, Canada.
Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment
Authors: Katsushima Keisuke , Natsume Atsushi , Ohka Fumiharu , Shinjo Keiko , Hatanaka Akira , Ichimura Norihisa , Sato Shinya , Takahashi Satoru , Kimura Hiroshi , Totoki Yasushi , Shibata Tatsuhiro , Naito Mitsuru , Kim Hyun Jin , Miyata Kanjiro , Kataoka Kazunori , Kondo Yutaka 
Published: December 2016

AbstractTargeting self-renewal is an important goal in cancer therapy and recent studies have focused on Notch signalling in the maintenance of stemness of glioma stem cells (GSCs). Understanding cancer-specific Notch regulation would improve specificity of targeting this pathway. In this study, we find that Notch1 activation in GSCs specifically induces expression of the lncRNA, TUG1. TUG1 coordinately promotes self-renewal by sponging miR-145 in the cytoplasm and recruiting polycomb to repress differentiation genes by locus-specific methylation of histone H3K27 via YY1-binding activity in the nucleus. Furthermore, intravenous treatment with antisense oligonucleotides targeting TUG1 coupled with a drug delivery system induces GSC differentiation and efficiently represses GSC growth in vivo. Our results highlight the importance of the Notch-lncRNA axis in regulating self-renewal of glioma cells and provide a strong rationale for targeting TUG1 as a specific and potent therapeutic approach to eliminate the GSC population.