bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of sex on the number of circulating endothelial microparticles and microRNA expression in middle‐aged adults
Authors: Bammert Tyler D. , Hijmans Jamie G. , Kavlich Philip J. , Lincenberg Grace M. , Reiakvam Whitney R. , Fay Ryan T. , Greiner Jared J. , Stauffer Brian L. , DeSouza Christopher A. 
Published: June 2017

New Findings
What is the central question of this study?
Are there sex‐related differences in the number of circulating endothelial microparticles (EMPs) and microparticle microRNA expression in middle‐aged adult humans?

What is the main finding and its importance?
Although the numbers of circulating endothelial microparticles do not differ between middle‐aged men and women, there are sex‐related differences in the expression of miR‐125a in activation‐derived EMPs and miR‐34a in apoptosis‐derived EMPs. Differences in circulating endothelial microparticle microRNA content may provide new insight into the sex‐related disparity in the risk and prevalence of vascular disease in middle‐aged adults.

The aims of this study were to determine: (i) whether circulating concentrations of endothelial microparticles (EMPs) differ in middle‐aged men compared with women; and (ii) whether there are sex‐related differences in microRNA expression in EMPs. Peripheral blood was collected from 30 sedentary adults: 15 men (56 ± 6 years old) and 15 women (56 ± 5 years old). Endothelial microparticles were defined by markers of activation (CD62e+) or apoptosis (CD31+/CD42b−) by flow cytometry. Expression of microRNA (miR‐34a, 92a, 125a and 126) in activation‐ and apoptosis‐derived EMPs was measured by RT‐PCR. Circulating activation‐ (33 ± 31 versus 39 ± 35 microparticles μl−1) and apoptosis‐derived EMPs (49 ± 54 versus 42 ± 43 microparticles μl−1) were not significantly different between men and women. Expression of miR‐125a (2.23 ± 2.01 versus 6.95 ± 3.99 a.u.) was lower (∼215%; P < 0.05) in activation‐derived EMPs, whereas expression of miR‐34a (1.17 ± 1.43 versus 0.38 ± 0.35 a.u.) was higher (∼210%; P < 0.05) in apoptosis‐derived EMPs from men compared with women. Expression of microRNA in circulating EMPs may provide new insight into sex‐related differences in cardiovascular disease.
Comparison of the vasodilatory effects of sodium nitroprusside vs. nitroglycerin
Authors: Ranadive Sushant M. , Eugene Andy R. , Dillon Gabrielle , Nicholson Wayne T. , Joyner Michael J. 
Published: June 2017

The vasodilatory mechanism of Nntroglycerin (NTG) is similar to sodium nitroprusside (SNP) in regard to action on guanosine 3′5′-monophosphate (cyclic GMP) via nitric oxide. However, it is unknown whether NTG can achieve the same magnitude of vasodilation in the forearm as SNP. Therefore, the purpose of the study was to evaluate the differences in forearm blood flow (FBF) and forearm vascular conductance (FVC) during escalating infusions of NTG vs. SNP at similar concentration doses and rates. We measured FBF using venous occlusion plethysmography (VOP) and Doppler ultrasound in eight young, healthy participants (mean age = 28 ± 2 yr) during four forearm volume (FAV)-specific doses (0.25, 0.5, 1, and 2 µg·100 ml FAV−1·min−1) of SNP and NTG infused via a brachial artery catheter. There was a significant difference in FVC of SNP vs. NTG only at the higher doses, as measured by VOP (14.9 ± 1.4 and 18.3 ± 1.5 vs. 11.6 ± 1.2 and 12.5 ± 1.2 ml/dl FAV−1·min−1·100 mmHg−1). FVC as measured by Doppler ultrasound unadjusted for FAV was significantly different at the lowest and the higher two doses of SNP compared with NTG (202.1 ± 25.8, 329.4 ± 46.7, and 408 ± 63.5 vs. 142.9 ± 22.4, 217.2 ± 18.8, and 247.5 ± 18.2 ml·min−1·100 mmHg−1). SNP induces significantly higher vasodilatory actions compared with NTG. However, NTG is comparable in eliciting equivalent vasodilator effects to SNP during low concentration doses when measured by VOP. Importantly, for forearm pharmacology studies, NTG can elicit marked endothelium-independent forearm vasodilation. NEW & NOTEWORTHY We compared the vasodilatory capacities of NTG vs. SNP at similar concentration doses and rates into the forearm. Based on the results of the study, it may be feasible to use intra-arterial NTG as a measure of endothelial-independent vasodilator in research studies. However, NTG dosing may need to be higher if used as an endothelial-independent vasodilator due to significant differences in the vasodilatory effects during higher doses of SNP compared with NTG.
Venetoclax Synergizes with Radiotherapy for Treatment of B-cell Lymphomas
Authors: O'Steen Shyril , Green Damian J. , Gopal Ajay K. , Orozco Johnnie J. , Kenoyer Aimee L. , Lin Yukang , Wilbur D. Scott , Hamlin Donald K. , Fisher Darrell R. , Hylarides Mark D. , Gooley Theodore A. , Waltman Amelia , Till Brian G. , Press Oliver W. 
Published: June 2017

Abstract
Constitutive B-cell receptor signaling leads to overexpression of the antiapoptotic BCL-2 protein and is implicated in the pathogenesis of many types of B-cell non-Hodgkin lymphoma (B-NHL). The BCL-2 small-molecule inhibitor venetoclax shows promising clinical response rates in several lymphomas, but is not curative as monotherapy. Radiotherapy is a rational candidate for combining with BCL-2 inhibition, as DNA damage caused by radiotherapy increases the activity of pro-apoptotic BCL-2 pathway proteins, and lymphomas are exquisitely sensitive to radiation. We tested B-NHL responses to venetoclax combined with either external beam radiotherapy or radioimmunotherapy (RIT), which joins the selectivity of antibody targeting with the effectiveness of irradiation. We first tested cytotoxicity of cesium-137 irradiation plus venetoclax in 14 B-NHL cell lines representing five lymphoma subtypes. Combination treatment synergistically increased cell death in 10 of 14 lines. Lack of synergy was predicted by resistance to single-agent venetoclax and high BCL-XL expression. We then assessed the efficacy of external beam radiotherapy plus venetoclax in murine xenograft models of mantle cell (MCL), germinal-center diffuse large B-cell (GCB-DLBCL), and activated B-cell (ABC-DLBCL) lymphomas. In each model, external beam radiotherapy plus venetoclax synergistically increased mouse survival time, curing up to 10%. We finally combined venetoclax treatment of MCL and ABC-DLBCL xenografts with a pretargeted RIT (PRIT) system directed against the CD20 antigen. Optimal dosing of PRIT plus venetoclax cured 100% of mice with no detectable toxicity. Venetoclax combined with radiotherapy may be a promising treatment for a wide range of lymphomas Cancer Res; 77(14); 3885–93. ©2017 AACR.
A Riddling Recipe?
Authors: Overduin Floris 
Published: June 2017

Abstract
This article provides a detailed interpretation and suggests a literary background for the brief (26 verses) elegiac recipe against colic (SH 690), written by Philo of Tarsus in the first century AD. Although on one level it is a serious pharmacological prescription, on another level it is also a literary piece, concerned with a marked tone of voice, Homeric play, and general display of paideia. Particularly its play of substituting certain ingredients with mythological riddles is striking. Its appeal to both doctors and men of culture fits the intellectual pattern of the culture of the Second Sophistic. As a poetic hybrid it also plays on different genres inherited from the previous Hellenistic era. Moreover, it constitutes a telling example of the late subgenre of elegiac pharmacology, in an era in which elegiac had all but vanished from Greek literature.
Development of a Student-Led Ambulatory Medication Reconciliation Program at an Academic Institution
Authors: Miranda Aimon C. , Cole Jaclyn D. , Ruble Melissa J. , Serag-Bolos Erini S. 
Published: June 2017

Objectives: To integrate fourth-year student pharmacists on advanced pharmacy practice experience (APPE) rotations within several different ambulatory clinics to perform medication reconciliations and enhance interdisciplinary practice. Methods: The study design was a descriptive, prospective multisite study among a variety of ambulatory care outpatient clinics. Student pharmacists were partnered with physicians to conduct medication reconciliations during clinic visits for 4 hours per week, with data collection from January 2016 to September 2016. This program originated from physician requests for additional pharmacy involvement and led to the development of a successful implementation strategy to involve student pharmacists in the medication reconciliation process. Results: Student pharmacists identified 537 medication discrepancies among 491 patients, including commission of medications (36%), documentation of previously omitted medications (27%), and incomplete patient allergy information (11%). Students spent an average of 10 minutes on each encounter. Conclusion: Documentation from this innovative program suggests improvement in medication reconciliation and enhanced patient care with limited time required of student pharmacists. A similar program could be developed and utilized at other clinical sites.
Appropriating the Weather
Authors: Hornby Louise 
Published: June 2017

Abstract
This article focuses on works by the Danish artist Olafur Eliasson, who has recently produced a number of large-scale and immersive installations, such as Ice Watch (2014) and, most famously, The Weather Project (2003). His human-made environments situate the human subject and human experience at their center, inviting the spectator to experience atmospheres and environments anew. Relying on the disorienting and defamiliarizing effects of enlarged scale and colored fog, Eliasson tools his art to increase the spectators’ awareness both of their environment and of their position as phenomenological subjects within it. The works’ emphasis on an ecology of individual encounter and feeling situate the experiencing subject at their center, providing an analogue to the human centering that marks the era of the Anthropocene. While Bruno Latour has claimed that Eliasson’s attempts at climate control are not consistent with a desire to control the elements, I argue instead that Eliasson’s environments are fully orchestrated affairs that share the technologies and efforts of the twentieth and twenty-first centuries’ militarization of climate control. Their phenomenological embrace, which has become a hallmark of much immersive art, relies on a stripe of self-centering that turns art into an occasion for feeling, foreclosing on critique. Eliasson’s spectacles are containers for experience, refusing the possibility of a radical externality that is uncontrolled or the possibility of atmospheres that exist beyond their human witness.
SPATIAL MOUNTING SYSTEM REKONSTRUCTION OF INDUSTRIAL BUILDING
Authors: Хасанов Ришат , Ладнушкин Алексей , Авхавдеев Рустем , Avkhadeev Rustem , Садыков Ринат 
Published: June 2017

To date, a considerable amount of walling the main buildings of the power plant, power plant, boiler buildings of the Soviet period of construction is limited to operational or emergency condition. The most damaged structures of the main buildings of enterprises of power include cladding: curtain wall panels and ribbed slab.
In article results of new technology of dismantle or replacement of protecting building designs of the main cases of the enterprises of power system without manufacture stop are resulted. Approbation of technology with acknowledgments of considerable economic benefit is spent and the patent for the invention is taken out.
What Does Continuity Between Preschool and Primary General Education Prevent?
Authors: Горлова  , Gorlova N. 
Published: June 2017

The article considers factors that prevent continuity in the implementation of pre-school and primary general education programs. The situations that give rise to pedagogical neglect of children at the preschool education level are discussed, and ways of overcoming it are suggested, in particular the use of such pedagogical technologies as conditional and controlled dialogue, listening, with the purpose of developing communicative and
speech skills of children.
Why clinical audit is important in midwifery: experiences from Kenya
Authors: Gicheha Edith Wathira , Richens Yana , Kivai Rosemary Mideva , Lavender Tina 
Published: June 2017

Background: Clinical are an assessment of working practice against an agreed standard, with the intention of identifying areas for improvement and recommending interventions to address them ( Mancey-Jones and Brugha, 1997 ). However, audits are not widely used in low or middle income countries. LAMRN set out to strengthen the capacity of midwives in Kenya to carry out clinical audits Aim: To describe the development of an audit project in Kenyatta National Hospital and Pumwani Maternity Hospital. Methods: Midwives were asked to identify auditable areas from clinical practice, which were ranked in order of priority. The problem with the highest score following ranking was chosen for audit and discussed with the management and clinical teams in each hospital. An audit protocol was then designed and an audit completed. This article highlights how the audit was undertaken; results are due to follow. Findings: Midwives in both hospitals agreed to audit postpartum haemorrhage and developed an audit proposal. This outlined the audit objectives, critical standards for the management of postpartum haemorrhage, data collection methods, timelines, roles of each team member and expected outcomes. Conclusions: Using a systematic approach, midwives in Kenya were able to identify an auditable problem, set clear objectives and standards to conduct the audit and develop methods to carry out the audit successfully.
Factors contributing to intrapartum stillbirth: a criteria-based audit to support midwifery practice in Zambia
Authors: Kasengele Chowa Tembo , Mowa Ruth , Katai Carol , Kunda Simon , Ng'ambi Mathew , Porteous Carol , Maimbolwa Margaret 
Published: June 2017

Background: Stillbirth is a poor pregnancy outcome and one that is common worldwide. It mostly occurs during the intrapartum period, which accounts for more than 50% of cases. Estimates suggest that 55% of stillbirths occur in low-to middle-income countries ( Lawn et al, 2011 ). Objective: To establish factors contributing to intrapartum stillbirth in Mansa General Hospital, Lupala Province, Zambia. Methods: In this retrospective audit, the files of 115 women were purposively reviewed in an initial baseline clinical audit and strategies introduced to change practice. A further 31 files were reviewed in a subsequent re-audit. Data were entered and analysed using SPSS version 16.0. Results: The study found that only 36 (33.3%) labouring women in the initial audit and 20 (65%) in the re-audit were managed using a partograph. Obstructed labour was the main cause of intrapartum stillbirths, which was the case for 65 women (55.7%) at baseline and 12 (38.7%) in the re-audit. Antepartum haemorrhage was the cause for 27 (23.5%) stillbirths in the baseline audit and 5 (16.1%) in the re-audit. Suboptimal care was observed in the initial audit, but thanks to intervention strategies, care improved in the subsequent audit. Conclusions: Improving intrapartum care in labour wards by skilled birth attendants and an improved referral system is critical if stillbirths are to be averted.
Understanding factors associated with antenatal care usage in Zambia
Authors: Masebe Esther , Mukonka Priscar , Muyuya Miriam , Engelbrecht Susheela , Thompson Anja , Chiyende Elizabeth 
Published: June 2017

Objective: To identify factors encouraging uptake of antenatal care (ANC). Methods: Data were collected using a semi-structured questionnaire. The study was conducted with 48 Zambian postpartum women who were over 18 years old, had given birth to a live-born infant, had begun ANC visits in the first trimester and/or had received four or more ANC visits during their most recent pregnancy. Findings: The results from this study suggest that a pregnant woman's decision to use ANC services is influenced by her perception of benefits of and services provided during these visits, as well as family, peer group, and community support. Conclusions: The women interviewed sought ANC early and/ or received the recommended number of visits during their pregnancy. A number of factors were found to positively contribute to this behaviour. As ANC is beneficial for the woman and her unborn baby, an approach should be used that reinforces these positive influences so that more women access ANC.
Knowledge and uptake of folic acid among pregnant women attending a secondary health facility in Nigeria
Authors: Adebo Omowumi O , Dairo David M , Ndikom Chizoma M , Adejumo Prisca O 
Published: June 2017

Background Folate deficiency is associated with poor pregnancy outcomes and is one of the most common vitamin deficiencies in women, especially those of reproductive age. Aims This study aimed to determine the level of knowledge and uptake of folic acid among a sample of pregnant women. Method A descriptive cross-sectional study, using a structured questionnaire, was carried out among 300 pregnant women attending antenatal clinics in one hospital in Oluyoro, Ibadan, Nigeria. Findings All participants claimed to have heard of folic acid and major source of information was health workers (77.3%). Only 11.8% knew that folic acid can prevent birth defects and just 22.7% knew the best time to start using folic acid. Almost all the women (98.3%) reported using folic acid in the current pregnancy, of whom 54.2% used it as prescribed. Education (P=0.002), marital status (P=0.001), plan of pregnancy (P=0.022), and maternal age (P=0.046) were significantly associated with knowledge of folic acid. Employment status was significantly associated with uptake of folic acid (P=0.004). Conclusions In this study, knowledge and uptake of folic acid was low among young, single and low education status women. Campaigns promoting periconceptional use of folic acid will be very useful in reaching women of child-bearing age particularly those pregnant and not registered for antenatal care.
Contribuindo na formação do leitor: propostas com duas obras infantojuvenis de Monteiro Lobato
Authors: Souza Costa Francisco Das Chagas 
Published: June 2017

RESUMO Este trabalho objetivou contribuir de modo teórico e pragmático na formação do leitor crítico, por intermédio do texto literário de natureza infantojuvenil. Nesse sentido, a opção por estudar Monteiro Lobato e o seu pioneirismo na literatura infantojuvenil brasileira se constituiu um imperativo do qual não se pôde prescindir. Dentro da vasta obra infantojuvenil lobatiana, conhecida popularmente como Sítio do Picapau Amarelo, constatou-se a possibilidade do uso didático de duas obras que, coadunadas, podem representar dois elementos indispensáveis à leitura: conhecimento linguístico/gramatical e o arcabouço literário/cultural. Tratou-se, respectivemente, das obras Emília no País da Gramática e O Picapau Amarelo. Estabeleceram-se, assim, direcionamentos pedagógicos no sentido de fazer do texto literário uma ponte significativa na formação do leitor. Sugeriu-se o uso das obras no 7º ano do Ensino Fundamental, o que, contudo, não se constituiu como uma posição inflexível. Entende-se que a proposta pode ser aplicada, com as devidas adequações, em todo em toda 2ª fase do Ensino Fundamental. Assim, é preciso observar cada realidade no sentido de verificar se os discentes estão aptos a lidar com as tarefas e atividades de leitura solicitadas. Feitas as devidas ressalvas, não se tem dúvida de que o melhor modo de formar leitores críticos é “semear” o prazer pelos textos e pelo conhecimento desde os primeiros anos de vida. Nessa esteira de pensamento, a literatura infantojuvenil cumpre uma função sine qua non.
Imersão Cristal: Princípios, recorrências e reverberações.
Authors: Fernandes Ciane , Morais Líria De Araújo , Scialom Melina , Vieira Alba Pedreira 
Published: June 2017

O artigo resulta de mesa apresentada no IX Congresso da ABRACE na Universidade Federal de Uberlândia, em novembro de 2016, em que integrantes do Coletivo A-FETO compartilharam e teceram considerações sobre suas vivências na obra Cristal (MAC-SP, junho de 2016). Cristal é uma Imersão somático-performativa com participação do público, que acontece a partir de Padrões de Crescimento, de Mudança ou Padrões Cristal. Este princípio composicional da Abordagem Somático-Performativa foi inspirado na mutabilidade inerente às formas cristalinas das teorias de Rudolf Laban. Coerente com essa perspectiva em crescimento inerente ao próprio movimento criativo, a obra é uma instalação-performance que inclui dança, escrita, projeções, paisagem sonora em tempo real, e que aconteceu durante os dias da exposição Vesica Piscis (sob curadoria de Maria Mommensohn), como uma obra de tempo continuado. O público não foi apenas um visitante, mas também trouxe suas contribuições cristal. Do mesmo modo, as reflexões aqui apresentadas contribuem para desdobramentos e sistematizações performativas e integradas, conectando vivências pessoais e coletivas, criação e(m) pesquisa.

ABSTRACT
The article results of a roundtable presented at the IX ABRACE Congress at Federal University of Uberlândia, in November 2016, in which members of the Collective A-FETO shared and developed considerations regarding their experience in Cristal (MAC-SP, June 2016). Cristal is a somatic-performative merger with audience participation that is based on Growth Patterns, Change Patterns or Crystal Patterns. This compositional principle of the Somatic-Performative Approach was inspired on the inherent mutability of the crystal forms of Rudolf von Laban’s theories. Coherent with this growing perspective – which is also inherent to creative movement -, the piece is a performance-installation that includes dance, writing, projection, soundscape in real time, and that happened during the days of the exhibition Vesica Piscis (curated by Maria Mommensohn) as a continuous durational piece. The audience is not only a visitor to the installation, but they can also bring their own crystal contributions. In the same way, the current reflections presented here contribute to performative and integrative unfolding and systematizations, connecting personal and collective experience, creative processes and/in research.

KEYWORDS
Merger, Somatic-performative approach, Crystal patterns, performance-installation.
Optimum combination of process parameters to optimize Surface Roughness and Chip Thickness during End Milling of Aluminium 6351-T6 Alloy Using Taguchi Grey Relational Analysis
Authors: Sreenivasulu Reddy 
Published: June 2017

In any machining operations, quality is the important conflicting objective. In order to give assurance for high productivity, some extent of quality has to be compromised. Similarly productivity will be decreased while the efforts are channelized to enhance quality. In this study, the experiments were carried out on a CNC vertical machining center (KENT and INDIA Co. Ltd, Taiwan make) to perform 10mm slots on Al 6351-T6 alloy work piece by K10 carbide, four flute end milling cutter as per taguchi design of experiments plan by L9 orthogonal array was choosen to determine experimental trials. Furthermore the spindle speed (rpm), the feed rate (mm/min) and depth of cut (mm) are regulated in these experiments. Surface roughness and chip thickness was measured by a surface analyser of Surf Test-211 series (Mitutoyo) and Digital Micrometer (Mitutoyo) with least count 0.001 mm respectively. Grey relational analysis was employed to minimize surface roughness and chip thickness by setting of optimum combination of machining parameters. Minimum surface roughness and chip thickness obtained with 1000 rpm of spindle speed, 50 mm/min feed rate and 0.7 mm depth of cut respectively. Confirmation experiments showed that Gray relational analysis precisely optimized the drilling parameters in drilling of Al 6351-T6 alloy.