bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magical Serialism: Modernist Enchantment in Elisabeth Lutyens'sO Saisons, O Châteaux!
Authors: FORKERT ANNIKA 
Published: July 2017

AbstractElisabeth Lutyens's music of the 1940s and 1950s provides one important, but frequently overlooked, link between British music and modernism before the so-called Manchester School. I argue that the main reason that the composer and her music have not yet received much attention is that early twentieth-century modernism, as it is commonly understood, has been gendered masculine. This article engages with the composition, texts, and reception of Lutyens's 1946 cantataO saisons, ô châteaux!in the context of other Lutyens pieces in order to argue that the composer sought to transcend what she perceived as a complex of disadvantages in the reception of her music (both regarding her gender and composition technique): the Cantata is an essentially melodic piece of ‘magical serialism’. Rather than ‘taming’ or ‘feminizing’ her serial music, Lutyens thus carves out a place for herself as Arthur Rimbaud's magician, reflecting on the set text ofO saisons, ô châteaux!and anticipating her later ‘credo’, in which she declares her music's allegiance with secret science rather than note counting or personal branding.
A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses
Authors: Yu Yufeng , Deng Yong-Qiang , Zou Peng , Wang Qian , Dai Yanyan , Yu Fei , Du Lanying , Zhang Na-Na , Tian Min , Hao Jia-Nan , Meng Yu , Li Yuan , Zhou Xiaohui , Fuk-Woo Chan Jasper , Yuen Kwok-Yung , Qin Cheng-Feng , Jiang Shibo , Lu Lu 
Published: July 2017

AbstractZika virus (ZIKV), a re-emerging flavivirus associated with neurological disorders, has spread rapidly to more than 70 countries and territories. However, no specific vaccines or antiviral drugs are currently available to prevent or treat ZIKV infection. Here we report that a synthetic peptide derived from the stem region of ZIKV envelope protein, designated Z2, potently inhibits infection of ZIKV and other flaviviruses in vitro. We show that Z2 interacts with ZIKV surface protein and disrupts the integrity of the viral membrane. Z2 can penetrate the placental barrier to enter fetal tissues and is safe for use in pregnant mice. Intraperitoneal administration of Z2 inhibits vertical transmission of ZIKV in pregnant C57BL/6 mice and protects type I or type I/II interferon receptor-deficient mice against lethal ZIKV challenge. Thus, Z2 has potential to be further developed as an antiviral treatment against ZIKV infection in high-risk populations, particularly pregnant women.
Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump
Authors: Su Chih-Chia , Yin Linxiang , Kumar Nitin , Dai Lei , Radhakrishnan Abhijith , Bolla Jani Reddy , Lei Hsiang-Ting , Chou Tsung-Han , Delmar Jared A. , Rajashankar Kanagalaghatta R. , Zhang Qijing , Shin Yeon-Kyun , Yu Edward W. 
Published: July 2017

AbstractResistance-nodulation-cell division efflux pumps are integral membrane proteins that catalyze the export of substrates across cell membranes. Within the hydrophobe-amphiphile efflux subfamily, these resistance-nodulation-cell division proteins largely form trimeric efflux pumps. The drug efflux process has been proposed to entail a synchronized motion between subunits of the trimer to advance the transport cycle, leading to the extrusion of drug molecules. Here we use X-ray crystallography and single-molecule fluorescence resonance energy transfer imaging to elucidate the structures and functional dynamics of the Campylobacter jejuni CmeB multidrug efflux pump. We find that the CmeB trimer displays a very unique conformation. A direct observation of transport dynamics in individual CmeB trimers embedded in membrane vesicles indicates that each CmeB subunit undergoes conformational transitions uncoordinated and independent of each other. On the basis of our findings and analyses, we propose a model for transport mechanism where CmeB protomers function independently within the trimer.
How gastrin-releasing peptide receptor (GRPR) and αvβ3 integrin expression reflect reorganization features of tumors after hyperthermia treatments
Authors: Hallasch Sandra , Frick Sindy , Jung Maximilian , Hilger Ingrid 
Published: July 2017

AbstractThe outcome of tumor treatment via hyperthermia in the clinic has been reported to be heterogeneous. Here, we assessed how the presence of gastrin-releasing peptide receptor (GRPR) and αvβ3 integrin together with the morphology of the vascularization reflects the growth behavior of tumors after hyperthermia treatment. MDA-MB-231 tumor bearing mice were treated either with high (46 °C) or low dose (42 °C) water hyperthermia for 60 min. Changes of GRPR and αvβ3 integrin expression were assessed via multiplexed optical imaging. Vascularization was reconstructed and quantified by µCT imaging after contrast agent injection. We found that high dose hyperthermia is capable of increasing the expression of GRPR, αvβ3 integrin, CD31, and Ki67 in tumors. Also the morphology of tumor vasculature changed (increased relative blood volume and small-diameter vessel density, decreased expression of α-SMA). Low dose hyperthermia induced comparatively moderate effects on the investigated protein expression pattern and vascular remodeling. We conclude that under defined circumstances, specific temperature doses affect the reorganization of tumor regrowth, which is triggered by residual “dormant” cells even though tumor volumes are transiently decreasing. Further on, GRPR, αvβ3 integrin expression are versatile tools to surveil potential tumor regrow during therapy, beyond the conventional determination of tumor volumes.
Fungal community succession and major components change during manufacturing process of Fu brick tea
Authors: Li Qin , Huang Jianan , Li Yongdi , Zhang Yiyang , Luo Yu , Chen Yuan , Lin Haiyan , Wang Kunbo , Liu Zhonghua 
Published: July 2017

AbstractFu brick tea is a unique post-fermented tea product which is fermented with microorganism during the manufacturing process. Metabolic analysis showed that most metabolites content were decreased during the manufacturing process of Fu brick tea, except GA (gallic acid). Illumina MiSeq sequencing of ITS gene amplicons was applied to analyze the fungal community succession. The genera Aspergillus, Cyberlindnera and Candida were predominant at the early stage of manufacturing process (from “primary dark tea” to “fermentation for 3 days”), but after the stage of “fermentation for 3 days” only Aspergillus was still dominated, and maintain a relatively constant until to the end of manufacturing process. The effects of metabolites on the structure of the fungal community were analyzed by redundancy analysis (RDA) and variation partitioning analysis (VPA). The results indicated that GCG (gallocatechin gallate), EGCG (epigallocatechin gallate) and GA as well as the interactions among them were the most probably ones to influence, or be influenced by the fungal communities during the fermentation process of Fu brick tea. This study revealed fungal succession, metabolite changes and their relationships, provided new insights into the mechanisms for manufacturing process of Fu brick tea.
Modeling Dominant and Recessive Forms of Retinitis Pigmentosa by Editing Three Rhodopsin-Encoding Genes in Xenopus Laevis Using Crispr/Cas9
Authors: Feehan Joanna M. , Chiu Colette N. , Stanar Paloma , Tam Beatrice M. , Ahmed Sheikh N. , Moritz Orson L. 
Published: July 2017

AbstractThe utility of Xenopus laevis, a common research subject for developmental biology, retinal physiology, cell biology, and other investigations, has been limited by lack of a robust gene knockout or knock-down technology. Here we describe manipulation of the X. laevis genome using CRISPR/Cas9 to model the human disorder retinitis pigmentosa, and to introduce point mutations or exogenous DNA sequences. We introduced and characterized in-frame and out-of-frame insertions and deletions in three genes encoding rhodopsin by co-injection of Cas9 mRNA, eGFP mRNA, and single guide RNAs into fertilized eggs. Deletions were characterized by direct sequencing and cloning; phenotypes were assessed by assays of rod opsin in retinal extracts, and confocal microscopy of cryosectioned and immunolabeled contralateral eyes. We obtained germline transmission of editing to F1 offspring. In-frame deletions frequently caused dominant retinal degeneration associated with rhodopsin biosynthesis defects, while frameshift phenotypes were consistent with knockout. We inserted eGFP or point mutations into rhodopsin genes by co-injection of repair fragments with homology to the Cas9 target sites. Our techniques can produce high frequency gene editing in X. laevis, permitting analysis in the F0 generation, and advancing the utility of X. laevis as a subject for biological research and disease modeling.
Effects of chloride ions on corrosion of ductile iron and carbon steel in soil environments
Authors: Song Yarong , Jiang Guangming , Chen Ying , Zhao Peng , Tian Yimei 
Published: July 2017

AbstractChloride is reported to play a significant role in corrosion reactions, products and kinetics of ferrous metals. To enhance the understanding of the effects of soil environments, especially the saline soils with high levels of chloride, on the corrosion of ductile iron and carbon steel, a 3-month corrosion test was carried out by exposing ferrous metals to soils of six chloride concentrations. The surface morphology, rust compositions and corrosion kinetics were comprehensively studied by visual observation, scanning electron microscopy (SEM), X-Ray diffraction (XRD), weight loss, pit depth measurement, linear polarization and electrochemical impedance spectroscopy (EIS) measurements. It showed that chloride ions influenced the characteristics and compositions of rust layers by diverting and participating in corrosion reactions. α-FeOOH, γ-FeOOH and iron oxides were major corrosion products, while β-Fe8O8(OH)8Cl1.35rather than β-FeOOH was formed when high chloride concentrations were provided. Chloride also suppressed the decreasing of corrosion rates, whereas increased the difficulty in the diffusion process by thickening the rust layers and transforming the rust compositions. Carbon steel is more susceptible to chloride attacks than ductile iron. The corrosion kinetics of ductile iron and carbon steel corresponded with the probabilistic and bilinear model respectively.
All solution-processed micro-structured flexible electrodes for low-cost light-emitting pressure sensors fabrication
Authors: Shimotsu Rie , Takumi Takahiro , Vohra Varun 
Published: July 2017

AbstractRecent studies have demonstrated the advantage of developing pressure-sensitive devices with light-emitting properties for direct visualization of pressure distribution, potential application to next generation touch panels and human-machine interfaces. To ensure that this technology is available to everyone, its production cost should be kept as low as possible. Here, simple device concepts, namely, pressure sensitive flexible hybrid electrodes and OLED architecture, are used to produce low-cost resistive or light-emitting pressure sensors. Additionally, integrating solution-processed self-assembled micro-structures into the flexible hybrid electrodes composed of an elastomer and conductive materials results in enhanced device performances either in terms of pressure or spatial distribution sensitivity. For instance, based on the pressure applied, the measured values for the resistances of pressure sensors range from a few MΩ down to 500 Ω. On the other hand, unlike their evaporated equivalents, the combination of solution-processed flexible electrodes with an inverted OLED architectures display bright green emission when a pressure over 200 kPa is applied. At a bias of 3 V, their luminance can be tuned by applying a higher pressure of 500 kPa. Consequently, features such as fingernails and fingertips can be clearly distinguished from one another in these long-lasting low-cost devices.
The relationships between serum fructosamine concentrations and lipid profiles in community-dwelling adults
Authors: Peng You-Fan , Wei Ye-Sheng 
Published: July 2017

AbstractWe examined the epidemiological associations between serum fructosamine and dyslipidemia indices in community-dwelling adults. Clinical characteristics and lipid profiles were analyzed in 1352 community-dwelling adults. The demographic characteristics and laboratory results were grouped according to the quartiles of serum fructosamine concentrations in all eligible individuals. From the bottom to the top quartile of serum fructosamine, there were graded increases in age, total cholesterol (TC), fasting blood glucose (FBG), total protein (TP), triglyceride (TG), total cholesterol/ high density lipoprotein-cholesterol (TC/HDL-C) and atherogenic index of plasma (AIP). Serum fructosamine was positive correlated with age, TC, FBG, TP, TG, TC/HDL-C and AIP in whole individuals. The positive correlations were then observed in both genders between serum fructosamine and TC, FBG, TP, TG. Two dominant factors were identified by principal component analysis. Logistic regression analysis showed that the two factors were associated with increased serum fructosamine with adjustment for gender, age, body mass index (BMI), FBG and TP. The similar results were observed in males, but not in females. Dyslipidemia tends to contribute to increased serum fructosamine concentrations in study population, suggesting that elevated serum fructosamine may herald an increased risk of cardiovascular disease among community-dwelling adults, especially in males.
Control of pattern formation during phase separation initiated by a propagated trigger
Authors: Kurita Rei 
Published: July 2017

AbstractUnderstanding pattern formation during phase separation is a key topic in materials science for the important role that patterns play in determining macroscopic physical properties. In this work, we show how pattern formation can be controlled using a phase-separation trigger propagating outwards from a point. We found a range of patterns, including a random droplet pattern, a concentric pattern and a dendritic pattern, depending on the speed at which the trigger propagates, while only the random droplet pattern is observed in a system with homogeneous cooling. We also found that the phase at the core of the concentric pattern periodically changes with time. In addition, we investigated pattern formation during phase separation induced by multiple propagated triggers. When we propagate the triggers from periodic points in space, a metastable regular hexagonal pattern is formed. We also found a bifurcation between a case where the majority phase becomes a droplet phase and a case where the minority phase adopts a droplet pattern. We also confirm the existence of a percolated, bicontinuous phase, even with an asymmetric composition.
Photochromic optical fibre for VIS spectrum range applications
Authors: Miluski P. , Kochanowicz M. , Zmojda J. , Dorosz D. 
Published: July 2017

The photochromic effect in poly(methyl methacrylate) (PMMA) fibre doped by 1,4‐bis(2‐methylstyryl)benzene is presented. The reversible photochromic effect of PMMA specimen and fibre has been checked using Nd‐YAG (355 nm) laser. Under the UV, the photodimerisation process leads to switching into the coloured form and wide absorption band below 670 nm was observed. The kinetic of photoswitching process is also presented. Moreover, the high transparency observed in visible (VIS) spectrum range, small dimensions, and high flexibility of presented functional polymeric fibre can be applied for numerous applications in optoelectronics devices.
Survey of Provider Preferences Regarding the Route of Misoprostol for Induction of Labor at Term
Authors: Towns Rachel , Quinney Sara , Pierson Rebecca , Haas David 
Published: July 2017

Objective To survey obstetrical provider preferences regarding use of misoprostol for induction of labor (IOL).
Methods An anonymous 25-question survey was distributed at an American College of Obstetricians and Gynecologists (ACOG) joint District V and VII Meeting in 2014 to obstetrics providers. The same survey was sent electronically to local providers. A separate survey was emailed to the labor and delivery nurses at two of the teaching hospitals in Indianapolis. The surveys queried provider demographics, dosing practice for misoprostol, opinions regarding different dosing strategies, and instructions on buccal administration.
Results A total of 113 (46.5%) providers responded. Of these, 92.9% used misoprostol for IOL, 73% preferred the vaginal route, 20% preferred buccal administration, and 7% oral administration. Only resident physician and midwife providers endorsed buccal route preference. Being a midwife independently predicted a preference for using buccal misoprostol (odds ratio [OR]: 125.8, 95% confidence interval [CI]: 7.9–1992.3). Additionally, 44 nurses completed the survey regarding administration techniques of buccal misoprostol. Also, 54.5% of nurses correctly instructed their patients on buccal administration techniques.
Conclusion Although not extensively studied, one-fifth of providers, particularly nurse midwives, prefer buccal administration of misoprostol for IOL. The majority of nurses correctly administered buccal misoprostol. There may be a need for further study and education about buccal administration of misoprostol for IOL.
A Review of Traditional Vaccine-Preventable Diseases and the Potential Impact on the Otolaryngologist
Authors: Greenlee Christopher , Newton Stephen 
Published: July 2017

Introduction A majority of otolaryngologists have not had direct experience with many vaccine-preventable diseases since the creation of national vaccination programs. Despite the elimination of endemic transmission of some of these diseases in the United States, outbreaks can occur anywhere and still pose a threat to public health around the world. Recent outbreaks and changing trends in exemption rates indicate that it is important for physicians to maintain a working knowledge of how these diseases present and of the recommended treatment guidelines.
Objectives This review will evaluate the current state of vaccination rates, vaccine exemption rates and disease incidence in the United States and in the world. It will also examine the clinical presentation and treatment recommendations of these diseases.
Data Synthesis United States estimated vaccination rates, vaccine exemption rates and vaccine-preventable disease incidences were obtained from data compiled by the Centers for Disease Control and Prevention. World vaccination rates and disease incidences were obtained from the World Health Organization databases, which compile official figures reported by member states. A PubMed literature review provided information on the current state of vaccination exemptions and outbreaks in the United States.
Conclusion Vaccination and vaccine exemption rates continue to put the United States and many areas of the world at risk for outbreaks of vaccine-preventable diseases. Clinical guidelines should be reviewed in the event of a local outbreak.
Microsurgical and Endovascular Treatments for Ruptured Paraclinoid Aneurysms
Authors: Zhao Qing-shuang , Hong Jing-fang , Zhao Lin , Zhang Xiao-jun , Wang Ru-mi , Wang Shou-sen 
Published: July 2017

Background The treatment of paraclinoid aneurysms can be challenging due to their relationship to the cavernous sinus, carotid siphon, and optic nerve. The goal of this retrospective analysis is to compare the efficacy and safety of microsurgical versus endovascular treatments for ruptured paraclinoid aneurysms.
Methods Medical records were reviewed to collect information about patient demographics, risk factors, diagnosis (the position and size of aneurysms), Hunt and Hess grade, and surgical method and outcomes, including modified Rankin Scale (mRS) at the time of discharge and 6 months later, complications, and death.
Results In total, 15 and 6 patients were recruited into the microsurgery and endovascular groups, respectively. No difference was detected regarding age, sex, risk factors, and Hunt and Hess grade. Most patients had ophthalmic segment aneurysms (87% versus 83%; p = 1.000) and small aneurysms (< 10 mm, 67% versus 100%; p = 0.102). In the microsurgical group, five patients (33%) had large aneurysms (10–25 mm); three patients (20%) had multiple aneurysms (all p > 0.05 compared with the endovascular group). The occlusion rate at 6 months was 93% in the microsurgical group and 100% in the endovascular group (p > 0.05). No difference was found regarding mRS or the complication and mortality rates between the two groups (all p > 0.05). The occurrence of complications was not related to the location and size of aneurysms (all p > 0.05).
Conclusions Our retrospective analysis indicates that good clinical outcomes can be achieved with both microsurgical and endovascular approaches. But further prospective randomized multicenter studies are needed to provide more evidence for clinical practice.
Entwicklung der anästhesieassoziierten Letalität und Einfluss auf das Outcome
Authors: Rosenberger Peter , Drexler Berthold 
Published: July 2017

ZusammenfassungDie anästhesieassoziierte Letalität konnte in den letzten Jahrzehnten deutlich gesenkt werden. Dies ermöglicht neben einer zuverlässigen Monitoringtechnik gut ausgebildetes Personal, das die patienten- und eingriffsspezifischen Risiken in das intraoperative Management mit einbezieht. Die richtige postoperative Betreuung von Patienten in Aufwachraum, PACU und Intensivstation ist ein weiterer zentraler Punkt für ein verbessertes Patienten-Outcome.
Anästhesie und Outcome: Einfluss der perioperativen Prozesse
Authors: Zieger Jörg , Häberle Helene 
Published: July 2017

ZusammenfassungIn den letzten Jahren hat sich die Rolle des Anästhesisten vom „Narkosearzt“ zum perioperativen Mediziner und Risikospezialisten enorm gewandelt. Die Patienten sind älter, multimorbide und werden zu immer umfangreicheren Eingriffen und Interventionen aufgeboten. Sozioökonomische Aspekte haben an Bedeutung zugenommen. Der Anästhesist ist als Wegbereiter eines guten Outcomes in nahezu alle perioperativen Prozesse involviert: präoperative Evaluation, Festlegung und Optimierung der prä- und intraoperativen Bedingungen, moderne intraoperative Anästhesieführung sowie eine postoperative, medizinisch indizierte, effektive und effiziente Behandlung der teilweise hochkomplexen Patienten. Die einzelnen perioperativen Prozessschritte auf diesem Weg werden in Anlehnung an etablierte Leitlinien und die Zunahme der gegenwärtigen Anforderungen beleuchtet. Schließlich wird ein besonderer Akzent auf die Erkenntnis gelegt, dass der perioperative Prozess nicht mit dem Operationsende abgeschlossen ist – postoperatives Outcome ist nicht zuletzt von postoperativen Komplikationen auf der Normalstation negativ beeinflusst. Das Risiko für Todesfälle nach Komplikationen, „Failure to rescue“, sollte frühzeitig erkannt und umgehend behandelt werden.
Gut schlafen und entspannen
Authors: Simianer Jessica 
Published: July 2017

Zusammenfassung
Interventionskoffer, die Neunte Wie oft liegen bei den Durchgängen im
Nachtdienst immer dieselben Patienten wach und äußern: „Ich kann nicht
einschlafen“? Manche kommen auch mitten in der Nacht verzweifelt aus dem Zimmer
und bitten um Hilfe, weil sie seit Stunden grübelnd wach liegen. In unserem
Interventionskoffer geben wir Ihnen das nötige Handwerkszeug, damit Ihre
Patienten entspannter einschlafen und ausgeruht aufwachen.
In den Schuhen des Anderen gehen
Authors: Weiße Dagmar 
Published: July 2017

Zusammenfassung
Einführung Fordernde und schwierige Pflegeprobleme treten im Umgang mit
Patienten immer wieder auf. Um diese zu reflektieren und zu lernen, damit
umzugehen, haben Lehrende und Lernende im Weiterbildungslehrgang Psychiatrische
Pflege an der Universitätsmedizin Mainz vor vier Jahren die systemische
Fallbesprechung ins Leben gerufen. Wie es gelingt, die Probleme aus der
Perspektive der Betroffenen zu erleben, Bekanntes zu hinterfragen und durch den
geänderten Blickwinkel neue Wege zu finden, schildert unsere Autorin.