bluuebunny/crossref_metadata_2025_split huggingface dataset:
Membrane microdomains and the regulation of HDL biogenesis
Authors: Genest Jacques , Schwertani Adel , Choi Hong Y. 
Published: November 2017

Purpose of review
The major cardio-protective function of HDL is to remove excess cellular cholesterol in the process of HDL particle formation and maturation. The HDL biogenic procedure requiring protein–lipid interactions has been incompletely understood, and here we discuss recent progress and insights into the mechanism of HDL biogenesis.

Recent findings
The initial and rate-limiting step of HDL biogenesis is the interaction between apoA-I and plasma membrane microdomains created by ATP-binding cassette transporter A1 (ABCA1) transporter. Computer simulation of molecular dynamics suggests that ABCA1 translocates phospholipids from the inner to the outer leaflet of the plasma membrane to create a transbilayer density gradient leading to the formation of an exovesiculated plasma membrane microdomain. The cryo-electron microscopy structure of ABCA1 suggests that an elongated hydrophobic tunnel formed by the extracellular domain of ABCA1 may function as a passageway to deliver lipids to apoA-I. In contrast to ABCA1-created plasma membrane microdomains, desmocollin 1 (DSC1) contained in a cholesterol-rich plasma membrane microdomain binds apoA-I to prevent HDL biogenesis. The identification of DSC1-containing plasma membrane microdomains as a negative regulator of HDL biogenesis may offer potential therapeutic avenues.

Summary
Isolation and characterization of plasma membrane microdomains involved in HDL biogenesis may lead to a better understanding of the molecular mechanism of HDL biogenesis.
VLDL triglyceride accumulation in skeletal muscle and adipose tissue in type 2 diabetes
Authors: Søndergaard Esben , Nielsen Søren 
Published: November 2017

Purpose of review
Insulin resistance is closely linked to accumulation of lipid outside adipose tissue (ectopic fat storage). VLDL particles transport lipids from the liver to peripheral tissues. However, whether abnormalities in VLDL-triglyceride storage in muscle and adipose tissue exist in type 2 diabetes has previously been unknown, primarily because of methodological difficulties. Here, we review recent research on VLDL-triglyceride storage.

Recent findings
In a recent study, men with type 2 diabetes had increased skeletal muscle VLDL-triglyceride storage compared to weight-matched nondiabetic men, potentially leading to intramyocellular triglyceride accumulation. In contrast, studies of adipose tissue VLDL-triglyceride storage have shown similar storage capacity in men with and without diabetes, both in the postabsorptive and the postprandial period. In the initial submission, studies have failed to show associations between lipoprotein lipase activity, considered the rate-limiting step in storage of lipids from lipoproteins, and VLDL-TG storage in both muscle and adipose tissue.

Summary
Differences in muscle VLDL-triglyceride storage may lead to ectopic fat storage and contribute to the development of type 2 diabetes, whereas the ability to store VLDL-triglyceride in adipose tissue is preserved in type 2 diabetes.
Trends of Magnet Ingestion in Children, an Ironic Attraction
Authors: Reeves Patrick Todd , Nylund Cade M. , Krishnamurthy Jayasree , Noel Robert Adam , Abbas Mazen I. 
Published: November 2017

ABSTRACTBackground and Objectives:Ingestion of rare earth magnets is a serious ongoing hazard for pediatric patients. Our study aims to investigate whether 2012 Consumer Product Safety Commission (CPSC) policy action, in coordination with efforts from consumer and physician advocacy groups, decreased the incidence of magnet ingestions in children in the United States since 2012.Methods:Data from the National Electronic Injury Surveillance System (NEISS) was used to evaluate trends in emergency department (ED) encounters with pediatric patients (<18 years) who presented with suspected magnet ingestions (SMI) from 2010 to 2015. National estimates of SMI were made using the NEISS‐supplied weights and variance variables.Results:An estimated 14,586 children (59% male, 50% age <5 years) presented to the ED for SMI from 2010 to 2015. A significant upward trend in magnet‐related ED visits preceded the CPSC action, with the peak ingestions of 3167 (95% confidence interval, 1612–4723) recorded in 2012. This was followed by a steady decrease in the rate of SMI to 1907 (95% confidence interval, 1062–2752) in 2015, an average annual decrease of 13.3%. Most importantly, post‐federal action estimates demonstrated a downward trend in overall SMI ED visits (P = 0.03).Conclusions:The frequency of magnet ingestions continued to rise from 2010 and then peak in 2012, followed by a decline in magnet ingestion ED visits during the post‐federal action years. This down trend emphasizes the importance of advocacy on decreasing magnet ingestions in children. Further study will be required to determine the impact of the court decision to lift the magnet ban in 2016.
Work placements at 14-15 years and employability skills
Authors: Messer David 
Published: November 2017

Purpose
In the UK, concern frequently has been voiced that young people lack appropriate employability skills. One way to address this is to provide work based placements. In general, previous research findings have indicated that young people find such placements useful because of help with career choice and relevant skills. However, most studies are retrospective and involve sixth form or degree students. The purpose of this paper is to extend previous research by collecting information before and after the placements.

Design/methodology/approach
This investigation involved questionnaires with nearly 300 14-15 year-old students who provided a pre- and post-placement self-reports about their employability skills and their work-experience hosts provided ratings of employability skills at the end of the placement.

Findings
There was a significant increase in student ratings of their employability skills from before to after the placement, and although the employers gave slightly lower ratings of some employability skills than the students, the two sets of ratings were reasonably close. In addition, the students had high expectations of the usefulness of the placements and these expectations were fulfilled as reported in the post-placement questionnaire.

Originality/value
These positive findings, extend the knowledge of the effects of work based placements, by focussing on the opinion of the young people themselves, using a pre- to post-placement design, by validating student self-reports with host employer ratings, and by focussing on a younger than usual age group.
Teacher change from a short-term certification programme and its comparison with that of a comparable long-term programme
Authors: Choi Tae-Hee 
Published: November 2017

Purpose
Using teacher certification to induce educational change is a common practice in many countries. However, teacher change from these certification programmes, in particular, from the widely used “short-term” programmes, is not given due attention. Do teachers change on short-term programmes? Is teacher development (TD) on short-term programmes qualitatively different from that of long-term programmes? Answering these questions, the purpose of this paper is to address the identified research gap and contribute to the ongoing discussion on an effective teacher education provision.

Design/methodology/approach
This comparative, qualitative study mainly draws on a case study of an in-service certification programme in South Korea. It also draws on publications which report on TD on a comparable, long-term certification programme in the USA. In both contexts, semi-structured interviews, lesson observations, and document research were conducted and the data were analysed through thematic content analysis.

Findings
Participants experienced three major, interrelated patterns of cognitive change: capturing and repositioning their assumptions, gaining and seeking pedagogical implications, and inner conflicts and reconciliation in both programmes. The participants also found their learning an emotional process. TD on the short-term programme was not qualitatively different from that of a comparable long-term programme.

Originality/value
This is the first paper which systematically investigates TD from a short-term training, as compared to a comparable long-term programme. This research has significance as it has implications for effective design and management of TD programmes.
The MEQUAL scale: measure of service quality in management education
Authors: Verma Sanjeev , Prasad Ram Komal 
Published: November 2017

Purpose
The purpose of this paper is to develop an empirically validated scale to measure the students’ perception of service quality in management education.

Design/methodology/approach
In this study, a three-stage systematic procedure of scale development has been adopted. Initially, extant literature review delineated the construct. Exploratory study techniques like focus group study and expert opinion helped in purifying the scale. In the second stage, principal component analysis with varimax rotation and Kaiser normalization (exploratory factor analysis) was used to refine the scale. Finally, multi-trait-multimethod matrix analysis was done to test the reliability and validity of the scale.

Findings
A 25-item multi-dimensional construct with six factors (academic aspect, professional assurance, behavioral responses and supports, industry institute interaction, non-academic aspects and physical support) was derived scientifically for measuring service quality in management education. Psychometrically, the scale exhibits internal consistency and remains consistent across the samples. The scale passes the requisite reliability and validity tests (construct, convergent, discriminant, nomological, predictive) with all values within limits.

Practical implications
Scientific and structured multi-dimensional construct for service quality in management education will help academicians, administrators and regulators in designing a process-oriented system for enhanced student satisfaction and performance.

Originality/value
This study is an incremental attempt to develop an empirically validated scale for measuring the service quality level and resultant satisfaction in management education.
Using performative knowledge production to explore marketplace exclusion
Authors: Burgess Gemma , Kelemen Mihaela , Moffat Sue , Parsons Elizabeth 
Published: November 2017

PurposeThis paper aims to contribute to understandings of the dynamics of marketplace exclusion and explore the benefits of a performative approach to knowledge production.Design/methodology/approachInteractive documentary theatre is used to explore the pressing issue of marketplace exclusion in a deprived UK city. The authors present a series of three vignettes taken from the performance to explore the embodied and dialogical nature of performative knowledge production.FindingsThe performative mode of knowledge production has a series of advantages over the more traditional research approaches used in marketing. It is arguably more authentic, embodied and collaborative. However, this mode of research also has its challenges particularly in the interpretation and presentation of the data.Research limitations/implicationsThe paper highlights the implications of performative knowledge production for critical consumer learning. It also explores how the hitherto neglected concept of marketplace exclusion might bring together insights into the mechanics and outcomes of exclusion.Originality/valueWhile theatrical and performative metaphors have been widely used to theorise interactions in the marketplace, as yet the possibility of using theatre as a form of inquiry within marketing has been largely neglected. Documentary theatre is revealing of the ways in which marketplace cultures can perpetuate social inequality. Involving local communities in the co-production of knowledge in this way gives them a voice in the policy arena not hitherto fully addressed in the marketing field. Similarly, marketplace exclusion as a concept has been sidelined in favour of marketplace discrimination and consumer vulnerability – the authors think it has the potential to bring these fields together in exploring the range of dynamics involved.
Geophysical greenfield exploration in the permo‐carboniferous Saar–Nahe basin—The Wiesbaden Geothermal Project, Germany
Authors: Deckert Hagen , Bauer Wolfgang , Abe Steffen , Horowitz Franklin G. , Schneider Ulrich 
Published: November 2017

ABSTRACTStructurally bound upwelling and outflowing hot fluids in the city of Wiesbaden suggest an interesting geothermal potential at the northern margin of the permo‐carboniferous Saar–Nahe basin, Germany. The Saar–Nahe basin in the Wiesbaden area was previously not a target for intensive geophysical prospecting of the deep underground. We present an exploration concept to investigate potential geothermal reservoirs near Wiesbaden for heat and power production. The acquired geophysical exploration data give new insights into the local geometry and internal structure of the Saar–Nahe basin. The exploration combines a wide range of methods, including the analysis of data, a dense grid gravity survey, as well as two‐dimensional and three‐dimensional seismic surveys. The resulting data, which for the first time reveal the deep structure of the Mainz and Saar–Nahe basins near Wiesbaden down to a depth of c. 4,000 m, show that the Saar–Nahe basin is strongly segmented and contains deep‐reaching active faults. Combining these information with numerical models of the stresses in the fault system and of the temperature distribution in the exploration area, a promising drilling target has been identified, which promise high permeability at a low risk of induced or triggered seismicity.
Casein‐Based Powders: Characteristics and Rehydration Properties
Authors: Felix da Silva Denise , Ahrné Lilia , Ipsen Richard , Hougaard Anni Bygvraa 
Published: November 2017

AbstractCasein‐based powders are gaining industrial interest due to their nutritional and functional properties, but they are also known to have poor rehydration abilities. The fundamental physical and chemical mechanisms involved in the rehydration of these powders are essential for determining the critical steps in the manufacturing processes and for developing casein powders with improved rehydration properties. A number of analytical methods have been developed to measure the rehydration ability of powders, but criteria for the selection of methods for casein‐based powders have not been provided. This review article provides an overview of the characteristics and methods for the production of casein‐based powders, methodologies to measure their rehydration properties, and it summarizes the current state of understanding regarding rehydration. Advancements have been made in the field; however, a fundamental understanding enabling improvement of the rehydration properties of these powders is still lacking.
Temporal trends (2002–2014) of incidence and shockable status of adult emergency medical service attended out‐of‐hospital cardiac arrest of presumed cardiac aetiology in Queensland
Authors: Pemberton Katherine , Bosley Emma 
Published: November 2017

AbstractObjectiveTo describe trends in incidence and shockable status of adult out‐of‐hospital cardiac arrest (OHCA) of presumed cardiac aetiology attended by Queensland Ambulance Service (QAS) paramedics between 2002 and 2014.MethodsThe QAS cardiac arrest registry was used to collect data. Analyses included age‐standardised rates by gender for all adults and older adults only (65 years+); age‐specific incidence rates of young adults (18–49), middle age adults (50–64) and five groups of older adults (65–69, 70–74, 75–79, 80–84 and 85+); and proportions of shockable versus non‐shockable initial rhythm together and by age group (young, middle age and older adults). Temporal trends were analysed.ResultsOver the 13 years, 32 346 cases of adult OHCA of presumed cardiac aetiology were recorded on the QAS OHCA registry. Age‐standardised incidence reduced significantly over time overall and in males only, in all adults and independently in older adults. A significant reduction independently in females was observed only in older adults. Age‐specific rates reduced in the 18–49, 70–74, 75–79 and 80–84 year age groups, increased in the 50–64 age group (largely attributable to females) and no significant trends were found in the 65–69 and 85+ age groups. The proportion of cases with an initially shockable rhythm significantly decreased overall. This trend was observed independently in older adults, but not in young or middle age adults.ConclusionAge‐standardised incidence has reduced with a period of stagnation in the middle age and early older years. These factors require consideration in data interpretation and strategy planning.
The impact of consumer inattention on insurer pricing in the Medicare Part D program
Authors: Ho Kate , Hogan Joseph , Scott Morton Fiona 
Published: November 2017

AbstractThe Medicare Part D program relies on consumer choice to provide insurers with incentives to offer low‐priced, high‐quality pharmaceutical insurance plans. We demonstrate that consumers switch plans infrequently and search imperfectly. We estimate a model of consumer plan choice with inattentive consumers and show that high observed premiums are consistent with insurers profiting from consumer inertia. We estimate the reduction in steady state plan premiums if all consumers were attentive. An average consumer could save $1050 over three years; government savings in the same period could amount to $1.3 billion or 1% of the cost of subsidizing the relevant enrollees.
Advertising as a search deterrent
Authors: Wang Chengsi 
Published: November 2017

AbstractThis article examines a monopoly firm's incentive to disclose information through advertising when consumers can choose between buying immediately and searching for additional information. Because sales drop when search reveals low match values to consumers, the firm has an incentive to deter search. We show that partial information disclosure emerges as a useful tool for search deterrence when search costs are low. Informative advertising and consumer search can be viewed as complements in producing information. Although transparency policies reduce search expenditures and improve purchase decisions, whether they are socially desirable depends on the magnitude of search costs.
Patent privateering, litigation, and R&D incentives
Authors: Lemus Jorge , Temnyalov Emil 
Published: November 2017

AbstractWe model “patent privateering”—whereby producing firms sell patents to Patent Assertion Entities (PAEs), which then license them under the threat of litigation—in a bargaining game. PAEs can negotiate higher licensing fees than producing firms because they cannot be countersued for infringement. Privateering produces two countervailing effects: it increases the offensive value of patents, whereas it decreases their defensive value and lowers the aggregate surplus of producing firms. Embedding the bargaining game into a Research and Development (R&D) contest for multiple complementary technologies, we find that privateering may increase R&D investments, even as it induces more litigation threats and reduces industry profits.
Consumers' activism: the cottage cheese boycott
Authors: Hendel Igal , Lach Saul , Spiegel Yossi 
Published: November 2017

AbstractWe study a consumer boycott on cottage cheese, organized in Israel on Facebook in the summer of 2011 following a steep price increase since 2006. The boycott led to an immediate decline in prices, which remain low even six years later. We find that (i) demand at the start of the boycott would have been 30% higher but for the boycott, (ii) own‐ and especially cross‐price elasticities increased substantially after the boycott, and (iii) post‐boycott prices are substantially below the levels implied by the post‐boycott demand elasticities, suggesting that firms were concerned with public backlash due to high prices.
The economic advantages of chain organization
Authors: Hollenbeck Brett 
Published: November 2017

AbstractThis article considers the rapid spread of chain firms in many industries. The conventional explanation is that chains generate economies of scale in costs. Alternatively, the structure of chains may enhance demand by helping firms develop reputations, among other reasons. I quantify the value of these explanations empirically with a large, detailed data set on the hotel industry, combining a reduced‐form analysis of revenues with a structural estimation of firm costs. Revenue analysis shows substantial evidence of a large chain premium. Cost estimation shows that after accounting for unobserved heterogeneity, chain‐affiliated firms receive no cost advantage relative to independent firms.
Feng shui And Emotional Response in the Critical care Environment (FARCE) study
Authors: Charles R. , Glover S. , Bauchmüller K. , Wood D. 
Published: November 2017

SummaryThe aim of this study was to investigate the relationship between nursing staff emotions and their surrounding environment, using the ancient system of feng shui. Two orientations of critical care bed spaces (wind and water groups, respectively) were mapped using a western bagua. Energy or ‘chi’ scores for nine emotions were calculated based on the positive or negative flow of chi in each of the two groups. During a two‐week period, nursing staff were allocated to work in a bed space in either the wind or water groups; nursing staff who were not allocated to a study bed space acted as a control group. Participating nursing staff completed a questionnaire, ranking nine emotional states and their overall inner harmony, using a 11‐point chi scale. In total, 108 questionnaires were completed. Critical bed space orientation according to feng shui principles was not related to nurse‐reported chi scores or inner harmony (p > 0.05 for all measurements). There was also poor correlation between the bagua‐predicted and reported chi scores for both the wind and water groups (R2 = 0.338 and 0.093, respectively). The use of feng shui to guide the layout of critical care bed spaces does not improve the emotional well‐being of nursing staff.
Carotid endarterectomy: the change in practice over 11 years in a stroke centre
Authors: Tse Gabrielle T. W. , Kilkenny Monique F. , Bladin Chris , Grigg Michael , Dewey Helen M. 
Published: November 2017

BackgroundRecent research evidence has impacted the practice of carotid endarterectomy (CEA). We aim to characterize changes in the practice and outcome of CEA over time in a single large‐volume stroke centre.MethodsAll patients who underwent CEA from 2004 to 2014 and carotid angioplasty and stenting (CAS) from 2003 to 2008 at an Australian metropolitan tertiary stroke centre hospital were included. Clinical data were analysed to identify time trends in choice of intervention, patient selection, preoperative imaging utilization, surgical timing and outcome.ResultsThere were 510 CEAs performed during 2004–2014 and 95 CASs during 2003–2008. The proportion of patients undergoing CEA compared to CAS increased from 60% to 90% from 2004 to 2008 (P < 0.001). CAS patients were more likely to have cardiac co‐morbidities. From 2004 to 2014, the proportion of CEA patients aged ≥80 years increased (P = 0.001) and the proportion of asymptomatic patients decreased (P = 0.003) over time. Median time from symptom onset to surgery decreased from 52 days (Q1: 25, Q3: 74) in 2004 to 8 days (Q1: 5, Q3: 37) in 2014 (P < 0.001). Use of preoperative ultrasonography decreased whilst CT angiography and the number of imaging modalities applied to each patient increased over time (P < 0.001). Overall, 5.9% of CEAs were complicated by death, stroke or acute myocardial infarction with no significant change over time.ConclusionThe trends in CEA practice at our centre align with international trends and guidelines. This study provides a representative indicator of Australian hospital practice, and illustrates how evidence from research is translated into clinical care.