bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidental Finding of Double Posterior Belly of Digastric Muscle in Head and Neck Cancer Patient
Authors: Sagalow Emily S. , Wang Richard , Babu Jay , Bigcas Jo-Lawrence , Okuyemi Oluwafunmilola 
Published: September 2024

Objectives: The digastric muscles have important roles in swallowing, chewing, speech, and landmark identification during neck dissection. The posterior belly of the digastric muscle (PBDM) is often useful for defining boundaries in surgical neck dissection as it contributes to the carotid, submandibular, and submental triangles. The cadaveric prevalence rate of anatomic variations in the digastrics has been reported to be 31.4% of the population with most occurring in relation to the anterior belly of the digastric muscle (ABDM). Few reports describe variations in the PBDM. While anatomic variants of the digastric muscles do not present with clinical manifestations, they can be mistaken as neck masses and contribute to intraoperative complications. Methods: We present a case report of a 73-year-old male with a past medical history significant for Parkinson’s Disease, who was incidentally found to have a duplicate PBDM intraoperatively while receiving surgical management of a left buccal squamous cell cancer. Results: Nine months prior to surgery, the patient began experiencing trismus and some mild dysphagia that were eventually worked up to reveal left buccal squamous cell carcinoma (SCC). Prior to this, the patient did not have clinical symptoms demonstrating dysfunction that could be related to or indicative of this anatomical abnormality preceding symptoms related to left buccal SCC growth. The procedure included a wide local excision, left modified radical neck dissection and left submental artery island flap with suprahyoid neck dissection. The superior duplicate PBDM was found to be overlying the stylohyoid muscle. Conclusions: It is important for surgeons operating in the head and neck to be aware of the possibility of this rare variation, and to be conscientious when it is identified so that it does not prohibit or limit a thorough dissection of the neck structures where oncologic clearance is paramount.
Sheathless RIRS in the era of slim and single use flexible ureteroscopy (ssFURS): Prospective analysis of clinical outcome
Authors: Abushamma Faris , Abu Alwafa Rola , Zyoud Sa’ed H 
Published: September 2024

Introducation: the purpose is to assess the feasibility of sheathless and time-limited retrograde intrarenal surgery (RIRS) using slim and single use flexible ureteroscopy (ssFURS) in view of the stone-free rate (SFR), complication rate and upfront ureteral stenting. Methods: A prospective, cross-sectional study of patients who underwent RIRS for kidney stones between December 2021 and December 2023 at our tertiary urology center was performed. Patient demographics, clinical presentations and stone characteristics were calculated. The SFR and complication rate were included. Results: Hundred and eighteen patients were included. The median age was 48 (35.7–60.0) years. Diabetes mellitus (DM) was present in 32 patients (27.1%). The median length of the kidney stones was 1.15 (range [0.4–3.0]), and the median width was 1 (range [0.05–3.7]). The pelvi-ureteric junction (PUJ) represented 75 (63.6%) patients. The lower pole stone (LP) consisted of 27 (22.9%) patients. Thirty-seven (31.4%) of the patients had multiple kidney stones. An overall complete SFR after the first session was observed for 94 (79.7%) patients. The second session of complete SFR was observed in 15 patients (12.7%). A median stone length of 1 (0.8–1.5) cm and a median stone width of 0.95 (0.7–1.3) cm were both significantly associated with a complete SFR after the first session ( p < 0.001). A single kidney stone in 69 (73.4%) patients was significantly more strongly associated with a complete SFR after the first session than was multiple kidney stones in 25 (26.6%) patients ( p = 0.027). Upfront stenting was performed in 74 patients (62.7%). The complete SFR after the first session was significantly greater in patients who underwent upfront stenting (65; 69.1%) than in those who underwent primary ssFURS (29; 30.9%, p = 0.004). Conclusion: Sheathless and time-limited RIRS using ssFURS is a feasible and successful procedure with low complication rate.
Improving access to cervical cancer screening: The impact of a Saturday pap smear clinic
Authors: Strelow Brittany , Stevens Joy , Fink Stephanie , Cole Kristin , O’Laughlin Danielle 
Published: September 2024

Introduction The implementation of cervical cancer screening and human papillomavirus (HPV) vaccination has significantly reduced cervical cancer rates. However, it remains the fourth most common cancer among women globally. Barriers to screening include personal, health system, and insurance factors. Methods To address these barriers, a “Saturday Pap smear Clinic” was established to increase accessibility. The study included female patients aged 21 to 65 from Southeast Minnesota, USA, who attended the clinic from September 2021 to April 2023. Results A total of 357 women attended the Saturday clinic, with a median age of 44 years; 70.6% were White. Abnormal Pap smear results were found in 13.8% of attendees, with 7.8% testing positive for HPV. Additional health maintenance was addressed. The majority of patients had a physician primary care provider (58.3%), followed by residents (26.3%), and nurse practitioner/physician associates (15.4%). Discussion The clinic demonstrated a high fill rate of 86.15%, indicating demand for non-traditional appointment times. Despite this, disparities in access were noted, with primarily White and English-speaking women utilizing the clinic. The clinic showed improved outcomes compared to national screening rates, highlighting the importance of timely preventative care.
Is Conservative Management of Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features (NIFTP) Possible in Children?
Authors: Celtik Ulgen , Ertan Yesim , Ozen Samim , Goksen Damla , Celik Ahmet 
Published: September 2024

Background: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a newly recognized entity with benign clinical characteristics. We aim to compare NIFTP with invasive encapsulated follicular variant papillary carcinoma (fvPTC) and to discuss the management. Methods: Records of patients with fvPTC and NIFTP between 2016 and 2022 were reviewed retrospectively. Two groups were compared according to demographics, surgical management, postoperative management, and long-term follow-up. Results: Twenty patients were included in the study, with 10 in NIFTP group and 10 in fvPTC group. The mean age at operation was 14.10 ± 2.61 years. Demographics and preoperative nodule sizes ( P = .912) were statistically similar between the 2 groups. Although lobectomy was more common in the NIFTP group, this difference was not statistically significant compared to the fvPTC group in terms of surgical treatment. Postoperatively, while no patient received radioactive iodine treatment(RAI) in NIFTP group, 6 patients in fvPTC group did ( P = .011). Five patients in NIFTP group and 3 in the fvPTC group were followed up with lobectomy only, without any adverse events or recurrence, for 47.50 ± 19.25 and 30.10 ± 19.25 months, respectively. Conclusion: In conclusion, NIFTP appears to be an indolent disease in children. Therefore, observation with lobectomy is sufficient, and RAI is not necessary.
Placement of the feline V-gel Advanced supraglottic airway device and tracheal selectivity during controlled mechanical ventilation: a clinical and tomodensitometric evaluation
Authors: Debuigne Morgane , Gatel Laure , Chesnel Mandoline 
Published: September 2024

Objectives The aims of the study was to assess the placement of the V-gel Advanced (V-gel-A) and to evaluate tracheal selectivity during controlled mechanical ventilation, using CT. Methods In this prospective clinical study, 20 healthy cats undergoing general anaesthesia for an elective procedure underwent four successive CT scans from the nose to the mid-abdomen: at baseline (no device); after the placement of the V-gel-A, after a controlled mechanical ventilation (CMV) period of 5 mins; and after the placement of an endotracheal tube (ETT). Using both a purpose designed position score and a gas score estimating the quantity of gas in different digestive regions, the position of the V-gel-A and presence of gas in the digestive tract at each step were evaluated. Number of attempts and times required to place the V-gel-A and ETT were recorded and compared. Results The V-gel-A was found to be correctly placed, with position scores of 3/5 in six cats, 4/5 in 13 cats and 5/5 in one cat. Imperfect positioning was due to minor axial rotation or incomplete occlusion of the oesophagus by the tip of the device. The gas scores significantly increased after placement of the V-gel-A compared with baseline and after CMV was initiated. Correct positioning of the device was mostly achieved at the first attempt; no significant difference was found in the time required to place V-gel-A vs ETT, nor in the number of attempts ( P >0.05). Conclusions and relevance The V-gel-A was clinically easy to place and use in both spontaneous and controlled ventilation. The device properly fitted the larynx and was never observed to occlude the airway. However, incomplete occlusion of the oesophagus was frequently observed and may lead to a lack of complete tracheal selectivity.
Correlation between macular sensitivity and kidney function in patients with diabetes
Authors: Adžić Zečević Antoaneta , Vujović Kalinić Valentina , Potpara Zorica , Zečević Ksenija 
Published: September 2024

Purpose The aim of this study is to investigate the correlation between kidney function in patients with diabetes and macular sensitivity at central 10° using microperimetry. Methods A cross-sectional study was carried out on 30 diabetic patients (58 eyes). A full-threshold microperimetry of the central 10° of retina (the macula) was performed on all subjects, consisting of 37 measurement points, using a 4–2 representation strategy. Macular sensitivity was expressed as the average threshold value in decibels for the entire field tested. The correlation between macular sensitivity and GFR, as well as microalbuminuria, blood glucose and HbA1c, was calculated using Pearson correlation rank. Results A significant positive correlation was observed between GFR and macular sensitivity among both male and female study subjects. For male participants, the correlation was measured to r([16]) = [.615], p = [<.007] and r([15]) = [.844], p = [<.001] for the left and right eyes, respectively. As for female participants, the correlation was r ([9]) = [.903], p = [<.001] and r([10]) = [.941], p = [<.001] for the left and right eyes, respectively. The correlation between macular sensitivity and the following variables was statistically insignificant: microalbuminuria, blood glucose, and HbA1c. Conclusion Despite intact visual acuity measured on standard ophthalmic examination, patients with impaired kidney function had decreased macular sensitivity. This emphasizes the importance of microperimetry in preventative care and detection of early signs of diabetic retinopathy. Furthermore, we should consider the use of microperimetry as an auxiliary tool for monitoring kidney function in diabetics.
Gendered parenting and gender role attitude among children
Authors: Krishna Sangili , Thomas Tissy Mariam , Sreekumar Sringa 
Published: September 2024

In a society rife with gender stereotypes and discrimination, children frequently learn to accept gender roles that are not necessarily equitable to all genders. Many factors during childhood and adolescence impact children’s beliefs and actions about gender roles. These attitudes and behaviors are typically acquired and reinforced at home. Most research on gender socialization place greater emphasis on typical growth and average patterns across children. The present study investigated how gendered ideas and actions of parents influence their children’s attitudes about gender roles. The study examined gender stereotypes held by children about different concepts like occupation, appearance, play, and responsibilities, and how family contributed to their development. Data was collected from ten participants (of age between 4 and 6 years) from Kozhikode district, Kerala, India, using a semi-structured interview. The data was transcribed, and thematic analysis was performed. The study found that children had a solid gender-stereotyped viewpoint on all of the factors examined and that children make gender-stereotyped decisions, attitudes, and perceptions from a very young age. Role modeling and promoting distinct gendered behaviors are found to be the two ways through which parents and families impact children’s gender development. The present study has demonstrated that certain types of exposures from the family influence children’s learning of conventional gender roles. Society must establish a more gender-equitable context that will preserve the future psychological, social, and professional development of children.
Characterizing patient experiences with repeat artificial urinary sphincter revisions through quantitative surveys and qualitative patient interviews
Authors: Huffman Phillip J. , Ewachiw Gabriella , Johnson Ryan , Huang Mitchell M. , Dani Hasan , Knijnik Pedro G. , da Silva Arthur F. , Burnett Arthur L. , Mostwin Jacek L. , Wright Edward J. , Cohen Andrew J. 
Published: September 2024

Background: Artificial urinary sphincter (AUS) placement remains the gold-standard treatment for post-prostatectomy urinary incontinence (PPUI), despite their need for periodic surgical revision. Objective: To understand the experiences of patients who undergo repeat AUS revisions. Design: Mixed design including quantitative surveys and qualitative interviews for thematic analysis. Methods: Men with ⩾2 revisions were collected from a single-institution, retrospective database of AUS patients. Participants were interviewed about their prostatectomy, incontinence, AUS placement, and revisions. A survey was administered utilizing validated tools (e.g., Decision Regret Scale (DRS), Incontinence Impact Questionnaire-7) for quantitative analysis. Interview transcripts were used for qualitative thematic analysis. Results: Of 26 respondents, 20 completed the interview. Twenty-three men completed the survey. The mean DRS score for prostatectomy was 24 (standard deviation (SD) = 27), indicating low regret. Median Incontinence Impact Questionnaire score was 54 (SD = 27), with 70% of participants describing their PPUI as “severe.” Participants experienced a significant decrease in daily pad usage with AUS placement (5.5 pre-AUS vs 1.4 post-AUS, p < 0.0001). Qualitative analysis revealed themes involving prostatectomy urgency, physician–patient relationships, expectation setting, and quality of follow-up. Most participants (96%) were satisfied with their initial AUS placement and endorsed a positive relationship with their urologist. However, 22% of participants were unaware of device limitations, including the need for revision. Some participants (26%) were uncertain of the status of their AUS, while some participants (35%) desired improved follow-up. Conclusions: Initial improvement and positive experiences with urologists motivate patients to undergo AUS repeat revision. Urologists should emphasize the limitations of the AUS before placement and follow up with patients to evaluate their needs for future care.
Spatial variation and determinants of traditional birth attendants utilization among women of reproductive age in Ethiopia: Spatial and multilevel analysis study
Authors: Ali Mohammed Seid , Getaneh Mekonen Enyew , Workneh Belayneh Shetie 
Published: September 2024

Background: Traditional birth attendant utilization has become a common malpractice and a leading cause of maternal morbidity and mortality in the developing world, such as Ethiopia. Therefore, this study was aimed at determining the geospatial variation and determinant factors of traditional birth attendant utilization among mothers of reproductive age in Ethiopia. Methods: The data were taken from the 2019 Ethiopian Demographic and Health Survey. Arc GIS, Excel, and STATA-14 software were used for the data analysis. The adjusted odds ratio with a 95% confidence interval was used to declare significant determinants of traditional birth attendance among mothers of reproductive age in Ethiopia. Results: Among 5,753 mothers of reproductive age, 34.59% of them utilized traditional birth attendants in Ethiopia during the 2019 Ethiopian Demographic and Health Survey. There was a geospatial variation of traditional birth attendants among mothers of reproductive age in Ethiopia; the Global Moran’s index value was 0.39 with a p-value <0.001. The significant factors associated with traditional birth attendant utilization were the age of mothers; higher odds were observed among older mothers aged 35–49 years (AOR = 1.31; 95% CI (1.04–1.63)); educational level of mothers (AOR = 3.04; 95% CI (2.13–4.33)); higher odds were observed in uneducated mothers, wealth index (AOR = 2.76; 95% CI (1.83–4.19)); higher odds were observed among the poorer and poorest households, place of residence (AOR = 5.69; 95% CI (3.35–9.67)); and the regions; the highest odds were observed in Somali (AOR = 12.1; 95% CI (4.99–25.68)) and Afar (AOR = 7.13; 95% CI (2.37–21.38)). Conclusions: The utilization of traditional birth attendants among reproductive-age mothers became a major public health concern, and the distribution showed geo-spatial variations among the regions of the country. We recommend taking appropriate measures to alleviate the current problem by improving access to maternal healthcare services.
High-temperature behaviour of fluorcarletonite, KNa4Ca4Si8O18(CO3)4(F,OH)⋅H2O, from the Murun Alkaline Complex, Russia, appraised by experimental and theoretical methods
Authors: Mesto Ernesto , Lacalamita Maria , Kaneva Ekaterina , Shendrik Roman , Bogdanov Alexander , Merli Marcello , Schingaro Emanuela 
Published: September 2024

AbstractThe thermal behaviour of fluorcarletonite, KNa4Ca4Si8O18(CO3)4(F,OH)⋅H2O, from the charoitites of the Severny district at the Malyy Murun massif, Murun complex, NW Aldan Shield, Siberia, Russia, has been investigated in order to understand the temperature-induced changes in the crystal structure of this rare silicate. The study has been carried out combining in situ high-temperature single-crystal X-ray diffraction (T range 25–550°C), ex situ high-temperature Fourier-transform infrared spectroscopy (25–700°C) and ab initio calculations. An increasing trend of lattice parameters and cell volume was observed in the 150–550°C temperature range, when the mineral underwent a progressive dehydration process. At 550°C ~40% water loss was detected. If compared with the fluorcarletonite structure at room temperature, the partially dehydrated fluorcarletonite shows: the same space group (P4/mbm); increased distances between the oxygens of the H2O molecules (O11w and O12w) and their Na-centred octahedral cations (Na1 and Na2, respectively); distortion of the four- and six-member tetrahedral rings of the double silicate layer. The dehydration process mainly involves the oxygen at the O11w site which has a different local environment with respect to the oxygen at the O12w site. At T > 600°C, the complete dehydration is accompanied by deprotonation of the OH groups substituting for the F atoms and by the collapse of the structure when the CO2 is released. The adopted approach allowed definition of the temperature thresholds at which modifications occur in the fluorcarletonite crystal structure when subjected to controlled heating conditions. Our findings contribute to assessment of stability, reactivity and, more generally, the thermal behaviour of sheet silicates with fluorcarletonite-like topology.
Myeloid clonal hematopoiesis of indeterminate potential in patients with chronic lymphocytic leukemia
Authors: Vijenthira Abi , Volpe Virginia O. , Sekar Aswin , Santos Azevedo Roberta , Mikhaleva Mariia , Gibson Christopher J. , Martindale Stephen P. , Fardoun Rayan , Tyekucheva Svitlana , Ren Yue , Fernandes Stacey M. , Knisbacher Binyamin A. , Hahn Cynthia K. , Getz Gad , Wu Catherine J. , Davids Matthew S. , Brown Jennifer R. 
Published: September 2024

Abstract
Clonal hematopoiesis of indeterminate potential (CHIP) in patients with chronic lymphocytic leukemia (CLL) has not been extensively characterized. The objective of this study was to describe the prevalence of myeloid CHIP (M-CHIP) in patients with CLL, and to determine its association with time to first treatment (TTFT) and overall survival (OS). We retrospectively analyzed data from patients participating in a prospective CLL database at the Dana-Farber Cancer Institute who had standard-of-care targeted 95-gene next-generation sequencing (NGS) performed. A schema was devised to classify mutations as M-CHIP related. M-CHIP was analyzed as a binary (present/absent) and categorical (≥2 vs 1 vs 0 mutations) predictor. We included 966 patients (median age at time of NGS, 65 years; 38% female). Overall, 747 (77%) patients had NGS performed before CLL treatment, whereas 219 (23%) had it performed after receiving treatment. Median follow-up time from NGS was 1.9 years. The prevalence of M-CHIP in untreated (12%) and treated (24%) patients with CLL was similar to that described in previous literature. M-CHIP prevalence appeared to increase with age in untreated patients, but appeared consistent across age in treated patients, suggesting that treatment (85% had prior chemotherapy) may have an impact on M-CHIP emergence even in younger patients. The presence of ≥2 M-CHIP mutations was associated with OS, even accounting for prior treatment and age, but was driven by a small subset of patients (n = 28). M-CHIP was not associated with TTFT. These findings support continued work into characterizing the effects of M-CHIP in patients with CLL.
Sample size recalculation in three-stage clinical trials and its evaluation
Authors: Bokelmann Björn , Rauch Geraldine , Meis Jan , Kieser Meinhard , Herrmann Carolin 
Published: September 2024

Abstract
Background
In clinical trials, the determination of an adequate sample size is a challenging task, mainly due to the uncertainty about the value of the effect size and nuisance parameters. One method to deal with this uncertainty is a sample size recalculation. Thereby, an interim analysis is performed based on which the sample size for the remaining trial is adapted. With few exceptions, previous literature has only examined the potential of recalculation in two-stage trials.

Methods
In our research, we address sample size recalculation in three-stage trials, i.e. trials with two pre-planned interim analyses. We show how recalculation rules from two-stage trials can be modified to be applicable to three-stage trials. We also illustrate how a performance measure, recently suggested for two-stage trial recalculation (the conditional performance score) can be applied to evaluate recalculation rules in three-stage trials, and we describe performance evaluation in those trials from the global point of view. To assess the potential of recalculation in three-stage trials, we compare, in a simulation study, two-stage group sequential designs with three-stage group sequential designs as well as multiple three-stage designs with recalculation.

Results
While we observe a notable favorable effect in terms of power and expected sample size by using three-stage designs compared to two-stage designs, the benefits of recalculation rules appear less clear and are dependent on the performance measures applied.

Conclusions
Sample size recalculation is also applicable in three-stage designs. However, the extent to which recalculation brings benefits depends on which trial characteristics are most important to the applicants.