bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pretreatment 18F-Fluorodeoxyglucose Positron Emission Tomography Standardized Uptake Values and Tumor Size in Medically Inoperable Nonsmall Cell Lung Cancer Is Prognostic of Overall 2-Year Survival After Stereotactic Body Radiation Therapy
Authors: Kocher Madison R. , Sharma Anand , Garrett-Mayer Elizabeth , Ravenel James G. 
Published: December 2017

Objective
The aim of this study was to determine prognostic value of tumor size and metabolic activity on survival for patients with early stage nonsmall cell lung cancer receiving stereotactic body radiation therapy.

Methods
We retrospectively evaluated the patients who underwent positron emission tomography–computed tomography scan before stereotactic body radiation therapy treatment. Tumor diameter, tumor volume, maximum standardized uptake value (SUVmax), standardized uptake value (SUV) average, and SUV volume were obtained. Cox regression analyses were performed to determine the associations between tumor characteristics and survival.

Results
The patients with large tumors and high SUVmax have worse survival than patients with small tumors and low SUVmax (hazard ratio [HR] = 3.47, P = 0.007). Patients with small tumors and high SUVmax (HR = 1.80; P = 0.24) and large tumors and low SUVmax (HR = 1.55; P = 0.43) had increased risk of death compared with patients with small tumors and low SUVmax.

Conclusions
Both increased tumor size and metabolic activity are associated with increased risk of death. Combining size and metabolic activity together is superior for predicting 2-year survival and identifying patients for whom survival is statistically worse.
Early identification of patients requiring massive transfusion, embolization or hemostatic surgery for traumatic hemorrhage: A systematic review and meta-analysis
Authors: Tran Alexandre , Matar Maher , Lampron Jacinthe , Steyerberg Ewout , Taljaard Monica , Vaillancourt Christian 
Published: December 2017

BACKGROUND
Delays in appropriate triage of bleeding trauma patients result in poor outcomes. Clinical gestalt is fallible and objective measures of risk stratification are needed. The objective of this review is to identify and assess prediction models and predictors for the early identification of traumatic hemorrhage patients requiring massive transfusion, surgery, or embolization.

METHODS
We searched electronic databases through to September 31, 2016, for studies describing clinical, laboratory, and imaging predictors available within the first hour of resuscitation for identifying patients requiring major intervention for hemorrhage within the first 24 hours.

RESULTS
We included 84 studies describing any predictor-outcome association, including 47 multivariable models; of these, 26 (55%) were specifically designed for prediction. We identified 35 distinct predictors of which systolic blood pressure, age, heart rate, and mechanism of injury were most frequently studied. Quality of multivariable models was generally poor with only 21 (45%) meeting a commonly recommended sample size threshold of 10 events per predictor. From 21 models meeting this threshold, we identified seven predictors that were examined in at least two models: mechanism of injury, systolic blood pressure, heart rate, hemoglobin, lactate, and focussed abdominal sonography for trauma. Pooled odds ratios were obtained from random-effects meta-analyses.

CONCLUSION
The majority of traumatic hemorrhagic prediction studies are of poor quality, as assessed by the Prognosis Research Strategy recommendations and Critical Appraisal and Data Extraction for Systematic Reviews of Modeling Studies checklist. There exists a need for a well-designed clinical prediction model for early identification of patients requiring intervention. The variables of clinical importance identified in this review are consistent with recent expert guideline recommendations and may serve as candidates for future derivation studies.
Persistent injury-associated anemia and aging: Novel insights
Authors: Loftus Tyler J. , Kannan Kolenkode B. , Carter Christy S. , Plazas Jessica M. , Mira Juan C. , Brakenridge Scott C. , Leeuwenburgh Christiaan , Efron Philip A. , Mohr Alicia M. 
Published: December 2017

BACKGROUNDHypercatecholaminemia and bone marrow dysfunction have been implicated in the pathophysiology of persistent injury-associated anemia. The elderly may be more vulnerable to bone marrow dysfunction due to high basal and peak catecholamine levels and impaired hematopoietic progenitor growth. We hypothesized that aging would adversely affect persistent injury-associated anemia.METHODSMale Sprague-Dawley rats aged 8 to 9 weeks and F344-BN rats aged 25 months were randomized to naive controls, lung contusion plus hemorrhagic shock (LCHS), and LCHS plus daily chronic restraint stress (LCHS/CS). Urine norepinephrine was measured on Days 1 and 7. Mobilization of hematopoietic progenitor cells (HPCs), bone marrow colony-forming units–erythroid growth, and peripheral blood hemoglobin, mean corpuscular volume (MCV), and red cell distribution width (RDW) were assessed on Day 7 (*p< 0.05 young vs. aged counterpart by one-way analysis of variance).RESULTSAged rats had higher norepinephrine levels at naive baseline (97* vs. 27 ng/mL) and 7 days following LCHS/CS when compared with young (359* vs. 127 ng/mL). Following LCHS/CS, HPC mobilization was greater among young rats when compared with aged (5.4 vs. 2.5%). Colony-forming units–erythroid growth was lower among aged animals for each group (naive: 47* vs. 65; LCHS: 40* vs. 50; LCHS/CS: 38* vs. 44 cells/plate). Aged naive rats had higher initial hemoglobin (15.2* vs. 14.3 g/dL) but lower MCV (48* vs. 59 fL/cell) and larger RDW at baseline and greater differences 7 days after LCHS/CS (MCV: 46* vs. 60 fL/cell; RDW: 17.4* vs. 16.3%).CONCLUSIONSCompared with young rats, aged rats had less HPC mobilization despite elevated basal and peak norepinephrine. Aged rats were disproportionately affected by impaired hematopoietic progenitor growth and an iron-restricted red blood cell phenotype at baseline, which persisted 7 days after injury. Further research is needed to assess how the clinical approach to persistent injury-associated anemia should differ for elderly trauma patients.
Fractals in Action: An fMRI study on the Generation of new Hierarchical Levels in Motor Sequences
Authors: Martins Mauricio J.D. , Bianco Roberta , Sammler Daniela , Villringer Arno 
Published: December 2017

AbstractGeneration of hierarchical structures, such as the embedding of subordinate elements into larger structures, is a core feature of human cognition. Discrimination of well-formed hierarchies is thought to rely on lateral prefrontal cortex (PFC). However, the brain bases underlying the active generation of new hierarchical levels remain poorly understood. Here, we created a new motor paradigm to isolate this active generative process. In fMRI, participants planned and performed (identical) movement sequences based on three previously learned rules: (1) a hierarchical ‘fractal’ rule that involved generation of new levels, (2) a linear ‘iterative’ rule adding items to existing hierarchical levels, and (3) simple ‘repetition’. We found that generation of new hierarchical levels (using the fractal rule) activated a bilateral motor planning-and imagery network, but did not involve lateral PFC. Conversely, adding items to existing hierarchical levels required M1 directly during execution. These results show that the generation of new hierarchical levels can be achieved without involvement of putative domain-general systems such as those ascribed to lateral PFC. We hypothesize that these systems might be important to parse hierarchical sequences in a multi-domain fashion but not necessarily to generate new hierarchical levels.
Skilled lipreaders read and listen to lips
Authors: Saalasti S. , Alho J. , Lahnakoski J.M. , Bacha-Trams M. , Glerean E. , Jääskeläinen I.P , Hasson U. , Sams M. 
Published: December 2017

ABSTRACTOnly a few of us are skilled lipreaders while most struggle at the task. To illuminate the poorly understood neural substrate of this variability, we estimated the similarity of brain activity during lipreading, listening, and reading of the same 8-min narrative with subjects whose lipreading skill varied extensively. The similarity of brain activity was estimated by voxel-wise comparison of the BOLD signal time courses. Inter-subject correlation of the time courses revealed that lipreading and listening are supported by the same brain areas in temporal, parietal and frontal cortices, precuneus and cerebellum. However, lipreading activated only a small part of the neural network that is active during listening/reading the narrative, demonstrating that neural processing during lipreading vs. listening/reading differs substantially. Importantly, skilled lipreading was specifically associated with bilateral activity in the superior and middle temporal cortex, which also encode auditory speech. Our novel results both confirm previous results from few previous studies using isolated speech segments as stimuli but also extend in an important way understanding of neural mechanisms of lipreading.
Reticular adhesions: A new class of adhesion complex that mediates cell-matrix attachment during mitosis
Authors: Lock John G. , Jones Matthew C. , Askari Janet A. , Gong Xiaowei , Oddone Anna , Olofsson Helene , Göransson Sara , Lakadamyali Melike , Humphries Martin J. , Strömblad Staffan 
Published: December 2017

AbstractAdhesion to the extracellular matrix (ECM) persists during mitosis in most cell types. Yet, classical adhesion complexes (ACs), such as focal adhesions and focal complexes, do and must disassemble to enable cytoskeletal rearrangements associated with mitotic rounding. Given this paradox, mechanisms of mitotic cell-ECM adhesion remain undefined. Here, we identify ‘reticular adhesions’, a new class of AC that is mediated by integrin αvβ5, formed during interphase and preserved at cell-ECM attachment sites throughout cell division. Consistent with this role, integrin β5 depletion perturbs mitosis and disrupts spatial memory transmission between cell generations. Quantitative imaging reveals reticular adhesions to be both morphologically and dynamically distinct from classic focal adhesions, while mass spectrometry defines their unique composition; lacking virtually all consensus adhesome components. Indeed, remarkably, reticular adhesions are functionally independent of both talin and F-actin, yet are promoted by phosphatidylinositol-4,5-bisphosphate (PI-4,5-P2). Overall, the distinct characteristics of reticular adhesions provide a unique solution to the problem of maintaining cell-ECM attachment during mitotic rounding and division.
Prevalence, mechanisms and comparison of detection methods of fosfomycin resistance inE. colifrom urinary tract infections
Authors: Cottell Jennifer L. , Webber Mark A. 
Published: December 2017

AbstractAs numbers of bacterial isolates resistant to first line antibiotics rise there has been a revival in the use of older drugs such as fosfomycin. Fosfomycin is a cell wall inhibitor with a unique mode of action, increasingly used in the treatment of urinary tract infections. In this study, the prevalence of fosfomycin resistantE. coliin a panel of 1000 urine isolates was investigated. Three different clinically used fosfomycin susceptibility testing methods were assessed and genome sequencing used to characterise resistant isolates.Of the 1000 isolates, 676 wereE. coliof which initial susceptibility testing with the MAST Uri®system suggested 81 (12%) were fosfomycin resistant. Of these, 62 were subsequently confirmed as beingE. coli.However, using micro-broth dilution, agar dilution and E-test strips, a lower rate of 1.3% (8/62) ofE. coliisolates were robustly identified as being truly fosfomycin resistant; a prevalence comparable with other similar studies. The use of E-test and 96-well breakpoint plates gave results that were inconsistent and hard to interpret. Resistant isolates ofE. colibelonged to diverse MLST types and each had a unique set of chromosomal alterations in genes associated with fosfomycin resistance. Changes in GlpT and UhpT/UhpA transport systems were commonly identified, with 6/8 of the resistant isolates possessing amino-acid changes or deletions absent in susceptible strains. Fosfomycin resistant isolates were not multiply drug resistance and did not carry plasmidic fosfomycin resistance genes. Therefore, the use of fosfomycin may be unlikely to drive selection of a particular clone or movement of transferrable resistance genes.Fosfomycin remains a viable option for the treatment ofE. coliin uncomplicated UTIs, different susceptibility testing platforms can give very different results regarding the prevalence of fosfomycin resistance with false positives a potential problem that may unnecessarily limit use of this agent.
Review and bibliometric analysis of Chinese agricultural economics research: 2006-2015
Authors: Chen Qiuhong , Geng Ning , Zhu Kan 
Published: December 2017

Purpose
The purpose of this paper is to reveal the distributional characteristics and evolutional patterns in source periodicals, topics, authors, funding, and institutes of research papers in Chinese Agricultural Economics so as to understand the current situations and developmental tendency of Chinese agricultural economics research over the past decade.

Design/methodology/approach
Using the citation analysis method, this paper analyzed the distributional characteristics and evolution of source periodicals, fields, authors and topics of 2,203 highly cited journal papers from the database of China National Knowledge Infrastructure (CNKI) and 189 cited journal papers from database of Social Sciences Citation Index (SSCI) in agricultural economics first-authored by Chinese scholars from 2006 to 2015.

Findings
First, over the past decade, agricultural economics research in China has seen a rapid development. Specially, 103 scholars and 42 institutes have played key roles in the development, and 12 Chinese periodicals and 3 international journals have been the most influential outlets. Second, the coverage of the topics in Chinese agricultural economics research is broad and has expanded over the past decade. The rural land issue has been the most popular topic, while the issues regarding rural institutional arrangements and industrialization in rural areas have been explored extensively. However, issues in other fields, such as agricultural markets and trade, rural labor, food safety, etc. have to be further studied. Third, the improvements of economic theory and quantitative analytic techniques, the supports from research funding, and an increase in the collaboration between Chinese scholars and those from other countries have made great contribution to the rapid development of Chinese agricultural economics research over the past decade.

Originality/value
This paper is an original work that identifies the most influential journal papers including highly cited journal papers from CNKI and cited journal papers from SSCI, using citation frequency and standard Essential Science Indicators method. This is a contribution relative to the methods used by previous studies, which did not account for frequency of citation of a paper. Moreover, this study is based on data from two databases, CNKI and SSCI, suggesting that the coverage of sample papers is broader compared to those of previous studies.
Agricultural organizations and the role of farmer cooperatives in China since 1978: past and future
Authors: Huang Zuhui , Liang Qiao 
Published: December 2017

Purpose
During the past four decades, agriculture and rural development in China has scored a great progress. Organization institution in agriculture is one of the domains with drastic innovations. The purpose of this paper is to map the emergence and evolution of various agricultural organizations in China since 1978. Development status and the trend of agricultural organization system are analyzed. Further, the role of farmer cooperatives is discussed.

Design/methodology/approach
Data used in the paper are mainly from statistical yearbooks and documents published by the government including Ministry of Agriculture and Bureau of Industry and Commercial. Both descriptive and deductive analyses are adopted to achieve different analytical purposes.

Findings
The vast small-farm sector, co-existence of various types of organizations, and innovation of other organizations will continue and sustain for a long-time period in China. Despite the fast development of modern farmers and various organizations, it is important that traditional farmers participate effectively in modern agriculture. Farmers act collectively via a cooperative in a desirable way, which determines the central position of farmer cooperatives in the agricultural organization system.

Research limitations/implications
This paper is a qualitative analysis on agricultural organizations in China, yet no quantitative estimation regarding the comparison of various organizations is conducted due to insufficient data.

Originality/value
This paper fills the gap of a comprehensive review of the emergence, development status, and trend of agricultural organizations in China.
From taxing to subsidizing farmers in China post-1978
Authors: Anderson Kym 
Published: December 2017

PurposeThe purpose of this paper is to document the pace and extent to which China’s policy regime has transitioned over the past four decades from explicitly and implicitly taxing to subsidizing its farmers relative to its producers of other tradable goods; to present projections of the world economy to 2030 that suggest China will continue to become more food import-dependent under current policies and productivity growth rates; and to explore alternative policy instruments for remaining food secure and ensuring that farmers are not losers from economic growth.Design/methodology/approachThe data used to estimate the extent of distortions to producer incentives come from freely available World Bank and OECD sources that allow direct comparisons of China’s policy developments with those of more- and less-advanced economies.FindingsThe estimates of nominal and relative rates of assistance to farmers reveal that China has made the transition from negative to positive assistance to farmers far faster than an average developing country, and almost as fast as its Northeast Asian neighbors did in earlier decades at similar levels of real per capita incomes. That helped to ensure China remained food self-sufficient during the first two decades of reform; but self-sufficiency is now declining and is projected to continue to do so over the next decade under current policies.Research limitations/implicationsPreventing food self-sufficiency from declining further by increasing agricultural protection would be very costly, and is now unnecessary, thanks to the information and communication technology revolution that enables the government to directly support the well-being of poor farm households with conditional cash transfers.Originality/valueThis review of indicators of distortions to agricultural incentives in China is based on estimates of nominal and relative rates of assistance and consumer tax equivalents that are in the public domain. Its originality is in presenting the estimates for China in a comparative perspective, showing how they have evolved over time and as real per capita incomes have grown, and relating that to developments in China’s self-sufficiency in agricultural and food products. The paper also points to more-efficient ways of achieving societal objectives than using policy instruments that distort producer and consumer prices.
The multilevel nomological net of team conflict profiles
Authors: O’Neill Thomas A. , McLarnon Matthew J.W. , Hoffart Genevieve , Onen Denis , Rosehart William 
Published: December 2017

PurposeThis paper aims to offer an integrative conceptual theory of conflict and reports on the nomological net of team conflict profiles. Specifically, it integrates social self-preservation theory with information-processing theory to better understand the occurrence of team profiles involving task conflict, relationship conflict and process conflict.Design/methodology/approachThe study collected data from 178 teams performing and engineering design tasks. The multilevel nomological net that was examined consisted of constructive controversy, psychological safety and team-task performance (team level), as well as perceptions of learning, burnout and peer ratings of performance (individual level).FindingsFindings indicated mixed support for the associations between conflict profiles and the hypothesized nomological net.Research limitations/implicationsFuture research should consider teams’ profiles of team conflict types rather than examining task, relationship and process conflict in isolation.Practical implicationsTeams can be classified into profiles of team conflict types with implications for team functioning and effectiveness. As a result, assessment and team launch should consider team conflict profiles.Originality/valueThe complexity perspective advanced here will allow research on conflict types to move forward beyond the extensive research examining conflict types in isolation rather than their interplay.
Classification and prioritization ofwaqflands: a Selangor case
Authors: Shabbir Malik Shahzad 
Published: December 2017

PurposeThe aim of this paper is to study the current status and development ofwaqflands in Malaysia, specifically in the state of Selangor, Malaysia and propose a new model for categorisation of itswaqflands. Previous studies onwaqflands and allocation of financial resources on these lands have been general and scanty.Design/methodology/approachThey lack the focus of categorisingwaqflands according to sectors, economic attributes and strategic locations so that it was not easy to match these lands to the kind of resources and investment models required for their development. The present research is carried out to categorisewaqflands and prioritise them according to four major sectors, namely agriculture, commercial, residential and religiousFindingsThe study is quantitative in nature and uses a multi criteria decision-making method, the Analytic Hierarchy Process (AHP) to prioritise thewaqflands by taking inputs from the officers working in Selangor Islamic Religious Council and some other related organisations. The study concludes with recommendations and suggestions for future research.Originality/valueI have proposed a new model for the categorisation ofwaqflands. Previous studies onwaqflands and its allocation of financial resources have been general and revealing. The present research is carried out to categorisewaqflands and prioritise them according to four major sectors, namely agriculture, commercial, residential and religious.