bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling
Authors: Romick-Rosendale Lindsey E. , Hoskins Elizabeth E. , Privette Vinnedge Lisa M. , Foglesong Grant D. , Brusadelli Marion G. , Potter S. Steven , Komurov Kakajan , Brugmann Samantha A. , Lambert Paul F. , Kimple Randall J. , Virts Elizabeth L. , Hanenberg Helmut , Gillison Maura L. , Wells Susanne I. 
Published: November 2015

Abstract
Purpose: Head and neck squamous cell carcinoma (HNSCC) remains a devastating disease, and Fanconi anemia (FA) gene mutations and transcriptional repression are common. Invasive tumor behavior is associated with poor outcome, but relevant pathways triggering invasion are poorly understood. There is a significant need to improve our understanding of genetic pathways and molecular mechanisms driving advanced tumor phenotypes, to develop tailored therapies. Here we sought to investigate the phenotypic and molecular consequences of FA pathway loss in HNSCC cells.
Experimental Design: Using sporadic HNSCC cell lines with and without FA gene knockdown, we sought to characterize the phenotypic and molecular consequences of FA deficiency. FA pathway inactivation was confirmed by the detection of classic hallmarks of FA following exposure to DNA cross-linkers. Cells were subjected to RNA sequencing with qRT-PCR validation, followed by cellular adhesion and invasion assays in the presence and absence of DNA-dependent protein kinase (DNA-PK) and Rac1 inhibitors.
Results: We demonstrate that FA loss in HNSCC cells leads to cytoskeletal reorganization and invasive tumor cell behavior in the absence of proliferative gains. We further demonstrate that cellular invasion following FA loss is mediated, at least in part, through NHEJ-associated DNA-PK and downstream Rac1 GTPase activity.
Conclusions: These findings demonstrate that FA loss stimulates HNSCC cell motility and invasion, and implicate a targetable DNA-PK/Rac1 signaling axis in advanced tumor phenotypes. Clin Cancer Res; 22(8); 2062–73. ©2015 AACR.
O texto semiótico da cibercultura: uma análise do processo modelizante da autoria no website Overmundo
Authors: Martins Beatriz Cintra 
Published: November 2015

<span style="font-family: Arial, Helvetica, sans-serif; font-size: 12px;">O artigo traz uma análise da publicação eletrônica Overmundo, tendo como referencial teórico a Semiótica da Cultura. A abordagem é focada especificamente na produção discursiva co-autorada, ou autoria colaborativa, existente neste </span><em style="font-family: Arial, Helvetica, sans-serif; font-size: 12px;">website</em><span style="font-family: Arial, Helvetica, sans-serif; font-size: 12px;">, através da exploração das linguagens que interagem para tecer a sua interface. Propõe-se, deste modo, uma interpretação do processo modelizante da autoria nesse ambiente como uma ação coletiva dialógica em um espaço público virtual.</span>
Práticas na linguagem e as manifestações da alteridade
Authors: Soares Rosana De Lima , Leite Andrea Limberto 
Published: November 2015

<p>RuMoRes, revista científica online dedicada aos estudos de comunicação, linguagem e mídias, chega à sua edição comemorativa, aquela de número 10, marcando seu quinto ano de atuação. Com visual atualizado pelo cuidadoso trabalho da designer Paula Paschoalick, o site foi reformulado de modo a acompanhar as tendências estéticas funcionais do meio onde se insere.</p>
Possibilidades textuais e gêneros discursivos
Authors: Soares Rosana De Lima , Limberto Andrea 
Published: November 2015

<p>RuMoRes, revista científica online dedicada aos estudos de comunicação, linguagem e mídias, apresenta sua 11ª edição refletindo uma preocupação constante das pesquisas na área de comunicações e artes, voltada justamente para os limites entre as práticas comunicacionais e artísticas. Tal desafio de desenhar as fronteiras entre os campos, ou mesmo o debate sobre a necessidade mesma de fazê-lo, está também relacionado às discussões teóricas sobre as transposições entre os diversos gêneros discursivos.</p>
Desafios à prática jornalística e representações sociais nas mídias
Authors: Soares Rosana , Limberto Andrea 
Published: November 2015

<p>A presente edição de RuMoRes, revista científica online dedicada aos estudos de comunicação, linguagem e mídias, tem a oportunidade editorial de entregar um variado conjunto de textos em torno da prática jornalística, que se espalham desde o Dossiê Desafios teórico-metodológicos para o estudo do jornalismo, reunindo textos apresentados no âmbito do 10º congresso da Associação Brasileira de Pesquisadores em Jornalismo, àqueles do corpo da edição. Olhados em conjunto, esses artigos desafiam a prática jornalística em sua riqueza simbólica ao tentar desenhar seus contornos com outras áreas do conhecimento e com outras práticas de saber, seja na associação ou no confronto com elas.</p>
<br>Jornalismo e estudos culturais: a contribuição de Jesús Martín-Barbero
Authors: Felippi Ângela , Escosteguy Ana Carolina 
Published: November 2015

<p>O artigo apresenta uma abordagem teórica e metodológica do jornalismo a partir dos estudos culturais. A proposição trata o jornalismo a partir de uma perspectiva cultural, levando em conta a integralidade do circuito comunicativo – produção, texto e consumo. Como exemplo de um protocolo metodológico desse tipo, toma-se o <em>mapa noturno</em> de Jesús Martín-Barbero (2003), no qual o olhar científico sobre o jornalismo é feito abordando o processo comunicacional e suas mediações, ou seja, na sua totalidade e complexidade. Como conclusão, tem-se a reivindicação de uma análise cultural do jornalismo mais como um desafio teórico do que efetivamente um modelo metodológico a ser seguido.</p>
Identidades e representações nos sistemas midiáticos (in)formativos: a charge e a construção da imagem do Outro
Authors: Oliveira Eliane , Santos Renata De Paula , Borges Rosane Da Silva 
Published: November 2015

<p>Este artigo tem como objetivo refletir sobre o papel das visualidades no processo de construção e reconstrução das identidades fluidas que nos habitam. Trata-se, portanto, de um artigo que enfrenta o desafio de pôr em relevo algumas nuances da produção e reprodução das identidades, tomando por base charges informativas, e de escandir tópicos relacionados ao processo das identificações que deriva de um imaginário que projeta representações. Tais discussões são oriundas de estudos empreendidos com pesquisadoras do mestrado em Comunicação da Universidade Estadual de Londrina (UEL). Entre os autores que norteiam a pesquisa, destacam-se, no campo da charge, L. Teixeira (2005) e, nas questões da identidade e representação, D. Kellner (2001), S. Moscovici (2003), R. Stam com E. Shohat (2005) e S. Hall (1997; 2001).</p>
A inserção dos sujeitos educacionais em processos midiáticos: usos/interações em discursos na construção de conhecimento para a produção acadêmica mediada pela internet
Authors: Silva Reia Silvia Rios Magalhães e 
Published: November 2015

<p>A partir das tecnologias e do processo de midiatização da sociedade contemporânea, o texto traz algumas reflexões acerca dos dados de uma pesquisa preliminar de doutorado que tem como objetivo central analisar usos e contextos, por meio dos discursos, das práticas de interações dos sujeitos educacionais com a internet na produção acadêmica. Para fins do artigo, tentou-se cruzar as concepções e proposições teóricas sobre os fenômenos das novas tecnologias e da sociedade em midiatização com os dados empíricos obtidos por meio das técnicas de questionário e de entrevista aplicadas com docentes e discentes participantes de grupos e núcleos de pesquisa do curso de serviço social da Universidade Federal do Piauí (UFPI).</p>
Narrativas midiáticas como catalisadoras de controvérsias públicas
Authors: Lelo Thales Vilela 
Published: November 2015

<p>O propósito deste artigo é o de avaliar a forma como determinadas narrativas midiáticas se concentram em destacar e instituir situações particulares de controvérsia pública em suas tramas. Frisando a importância de uma semiologia das mídias orientada para os contextos de enunciação, serão efetuadas análises de dois objetos recortados do universo do audiovisual, tomando por base a ideia de componente narrativo de controvérsias políticas presente nas discussões de Alain Bovet e Cédric Terzi. Através desta orientação, pretende-se destacar a maneira como estas tramas são elaboradas, convocando um trabalho de sensibilização para o fator de indignação apontado nelas e instigando a percepção das mesmas na cena pública através da atividade de interlocução emocional.</p>
Chicago – Arcetri 1933
Authors: Barreca Francesco 
Published: November 2015

On the evening of October 2, 1933 a most unusual event took place during the Century of Progress World Exposition in Chicago. To celebrate the visit of the renowned scientist Guglielmo Marconi and, by extension, the achievements of science in Italy, that night the lights of the fair were switched on using light emitted by the moon. This feat was realized thanks to the cooperation between the Radio Corporation of America (RCA), the Astronomical Observatory of Arcetri, and the Ente Italiano per le Audizioni Radiofoniche (EIAR). Its purpose was to illustrate – by means of the towering figures of Galileo and Marconi – the past and present greatness of Italian science.
Illustrating Pathologies in the First Years of the Miscellanea Curiosa, 1670–1687
Authors: Conforti Maria 
Published: November 2015

The Miscellanea Curiosa, sive Ephemeridum Medico-Physicarum Germanicarum, the learned periodical published in different German cities under the aegis of the Academia Leopoldina Naturae Curiosorum, contained many cases of an anatomical nature. The Miscellanea Curiosa in its first years actively participated in the development of anatomia practica, the anatomical practice of observing the signs of diseases in cadavers and connecting them to what had been observed at the bedside. The illustrations that accompanied the post-mortem reports published in the Miscellanea Curiosa allow one to assess the evolution of the pathological illustration itself. This article is thus intended to serve as a contribution to the rediscovery of the origins of this visual genre. A learned journal like the Miscellanea Curiosa, which appeared regularly, provided an ideal venue for the process of accumulating, cross-referencing and – in the final analysis – selecting, serializing and systematizing the knowledge that would form the foundations of modern pathology, by providing a wealth of evidence and images observed at the dissection table.
MONDILEX – towards the research infrastructure for digital resources in Slavic lexicography
Authors: Dimitrova Ludmila , Koseska-Toszewa Violetta , Garabík Radovan , Erjavec Tomaž , Iomdin Leonid , Shyrokov Volodymyr 
Published: November 2015

MONDILEX – towards the research infrastructure for digital resources in Slavic lexicographyThe paper presents activities of the EU project MONDILEX, Conceptual Modelling of Networking of Centres for High-Quality Research in Slavic Lexicography and their Digital Resources. The main objective of MONDILEX is to design the conceptual scheme of a research infrastructure that supports the networking of centres for high-quality research in traditional and digital Slavic lexicography.
Un modèle d’analyse de structures situationnelles de discours
Authors: Miczka Ewa 
Published: November 2015

A model for the analysis of situational discourse structuresIn this paper the author presents a model for the analysis of situational discourse structures applied to fait divers. Situational structures of discourse are defined as a sequence of experiential frames. Each frame permits to conceptualize one event forming a part of information introduced in discourse. The proposed model permits to analyze (1) the internal structure of experiencial frames activated in discours and (2) possible relations between frames identified in discourse. The author aims to present the role of situational structures in discourse comprehension – the process which implicates creation of discourse representation.
Shallow syntactic annotation in the corpus of Wrocław University of Technology
Authors: Radziszewski Adam , Maziarz Marek , Wieczorek Jan 
Published: November 2015

Shallow syntactic annotation in the corpus of Wrocław University of TechnologyIn this paper we present shallow syntactic annotation of The Wrocław University of Technology Corpus. We discuss some theoretical and practical considerations related to shallow parsing of Polish, then we present our annotation guidelines. The proposed annotation scheme includes chunking – four chunk types are defined with reference to the notion of accommodation and syntactic connotation, as well as annotation of four inter-chunk predicate-argument relations. Until now almost 18k chunk and 4k relation instances have been annotated. We believe that both the corpus and the annotation guideliness will prove their applicability in construction of automatic shallow parsers.
Does an Intrinsic Source Generate a Shared Low-Frequency Signature in Earth’s Climate and Rotation Rate?
Authors: Marcus Steven L. 
Published: November 2015

Abstract
Previous studies have shown strong negative correlation between multidecadal signatures in length of day (LOD)—an inverse measure of Earth’s rotational rate—and various climate indices. Mechanisms remain elusive. Climate processes are insufficient to explain observed rotational variability, leading many to hypothesize external (astronomical) forcing as a common source for observed low-frequency signatures. Here, an internal source, a core-to-climate, one-way chain of causality, is hypothesized. To test hypothesis feasibility, a recently published, model-estimated forced component is removed from an observed dataset of Northern Hemisphere (NH) surface temperatures to isolate the intrinsic component of climate variability, enhancing its comparison with LOD. To further explore the rotational connection to climate indices, the LOD anomaly record is compared with sea surface temperatures (SSTs)—global and regional. Because climate variability is most intensely expressed in the North Atlantic sector, LOD is compared to the dominant oceanic pattern there—the Atlantic multidecadal oscillation (AMO). Results reveal that the LOD-related signal is more global than regional, being greater in the global SST record than in the AMO or in global-mean (land + ocean) or land-only surface temperatures. Furthermore, the strong (4σ) correlation of LOD with the estimated NH intrinsic component is consistent with the view proffered here, one of an internally generated, core-to-climate process imprinted on both the climate and Earth’s rotational rate. While the exact mechanism is not elucidated by this study’s results, reported correlations of geomagnetic and volcanic activity with LOD offer prospects to explain observations in the context of a core-to-climate chain of causality.
Dynamics of the Changing Near-Inertial Internal Wave Field in the Arctic Ocean
Authors: Dosser Hayley V. , Rainville Luc 
Published: November 2015

ABSTRACTThe dynamics of the wind-generated near-inertial internal wave field in the Canada Basin of the Arctic Ocean are investigated using the drifting Ice-Tethered Profiler dataset for the years 2005 to 2014, during a decade when sea ice extent and thickness decreased dramatically. This time series, with nearly 10 years of measurements and broad spatial coverage, is used to quantify a seasonal cycle and interannual trend for internal waves in the Arctic, using estimates of the amplitude of near-inertial waves derived from isopycnal displacements. The internal wave field is found to be most energetic in summer when sea ice is at a minimum, with a second maximum in early winter during the period of maximum wind speed. Amplitude distributions for the near-inertial waves are quantifiably different during summer and winter, due primarily to seasonal changes in sea ice properties that affect how the ice responds to the wind, which can be expressed through the “wind factor”—the ratio of sea ice drift speed to wind speed. A small positive interannual trend in near-inertial wave energy is linked to pronounced sea ice decline during the last decade. Overall variability in the internal wave field increases significantly over the second half of the record, with an increased probability of larger-than-average waves in both summer and winter. This change is linked to an overall increase in variability in the wind factor and sea ice drift speeds, and reflects a shift in year-round sea ice characteristics in the Arctic, with potential implications for dissipation and mixing associated with internal waves.
An Impression of the Conference at St. Andrews
Authors: Finkelstein L. 
Published: November 2015

All scientists and technologists nowadays, and especially, perhaps, those concerned with instrumentation and control, suffer from the information revolution. A flood of publications, ranging from the erudite to the popular, and from the useful to the trivial, pours from the presses of the world. It is in fact becoming impossible to read all the abstracts in one's field, let alone all the papers. Conscious of the need to keep up to date, we often resort to the Conference as a means of finding out about the current state in some area of our art or science. Too often we are disappointed. From the arrival of the bulky bundle of pre-prints, which we have no hope of reading with the attention they require, right through the rapid presentation of some very difficult material by a rapporteur, we grow ever more confused. At best we emerge having made or renewed some personal contacts. The picture presented is, of course, a caricature, but is I think close enough to reality to be recognisable. The S.I.T. Conference on “Online measurement and inspection: their impact on quality” has, however, shown that given determination to do so, it is still possible to mount a technical meeting at which you can actually follow and enjoy all the papers.
A Dynamic Model for a Packed Batch Distillation Column
Authors: Kropholler H. W. , Spikins D. J. , Whalley F. 
Published: November 2015

An analytical solution to the batch distillation equations for packed columns is presented. The dynamic model thus formed has been compared with experimental results for a 4-inch packed column separating a binary mixture. The computer time for a solution was only a few seconds, thus rendering the model useful for on line optimisation purposes.
Electrohydraulic Control of Alternator Drives with Wide Speed Range
Authors: Steel G. K. 
Published: November 2015

Consideration is given to the problem of controlling the output speed of a hydraulic transmission system, when the main source of disturbance is the changing speed of the prime-mover. A control system is described which will maintain a constant output speed over a range of input speeds of the order of 10:1. It is shown that satisfactory performance cannot be achieved over this wide speed range by using normal feedback control. The addition of a feedforward control operation overcomes this difficulty and yields a system which offers high performance. This system is particularly advantageous when the moment of inertia of the driven load is high. The control system has been realised in the form of an electro-hydraulic system and the results of tests on a typical transmission system are presented.
Analysis of the Dynamic Response Characteristics of a Flow Meter for Measurement of Pulsating Flow of Liquids
Authors: Young F. G. 
Published: November 2015

An account of the design and development of a prototype flow meter for measuring the flow of liquids under transient conditions was presented by the author at the Symposium on the Measurement of Pulsating Flow at the University of Surrey, April 1970. The flow meter exhibited good transient behaviour in response to rapid flow variations and a favourable correlation existed between theoretically predicted and experimental steady flow results. This paper gives a derivation of the theory underlying the transient behaviour of the instrument and shows how the essentially non-linear equations of motion may be linearised to produce easily manageable linear equations. The good transient response characteristics are accounted for by virtue of the high value of ‘hydraulic stiffness’.
Control Valves: System Flow Characteristics and Controllability
Authors: Bishop D M 
Published: November 2015

A theoretical examination is made of the relationship between a control valve and the plant in which it is installed; the effect of valve size and characteristic on the relationship is described. From the theoretical basis, practical rules are devised for use at the design stage, also for later changes that may be necessary once the plant is in operation. Some well known practical difficulties are described, together with means of evading or overcoming them.
Hydratect®—A Range of Highly Reliable Self-Validating Water Presence Detectors
Authors: Hasler E. F. , Martin R. E. 
Published: November 2015

In conventional instruments high reliability is achieved by using a sound physical principle and ensuring that the system is well engineered with high quality components: the user's confidence in the ability of the instrument to perform correctly then has to be supported by frequent functional checks. Where such instruments are used to detect an infrequent condition, eg, the presence of unwanted water in parts of a steam turbine plant, checks must be made at even more frequent intervals to reveal any inability to operate correctly and this is costly and disadvantageous because of consequent hazards to the main plant. Furthermore, instrument malfunctions can inhibit wanted operation and can also give rise to false operations which may shut down a large plant unnecessarily. The patented philosophy used in the systems described results in greater availability and eliminates all need for routine testing. The paper outlines a range of water presence detectors (Hydratect) in which any instrument defect is made self-proclaiming thus eliminating the need for testing. This ‘multi-headed’ sytem permits false operations to be discounted and under rare conditions of a failure of one instrument path the system calls for maintenance but still continues to provide useful service. Although it is at present applied and is being increasingly used for the vital detection of unwanted water in steam turbine plant, the basic method is applicable to both binary and analogue transducers where exceptionally high reliability and availability are necessary. Examples arise wherever a hazard exists due to the possible malfunctioning of conventional instruments.
Flowmetering in the Oil Industry
Authors: Gold R C 
Published: November 2015

The article traces the use of flowmeters in the production and processing of crude oil and its refined products. Emphasis is placed on meters used for accounting purposes and wherever possible, the significance of measurement uncertainty at the various stages of oil production is expressed in financial terms. The article concludes that improved measurement accuracy is more likely to be achieved from improved calibration and operating procedures than from the use of different types of flowmeters.