bluuebunny/crossref_metadata_2025_split huggingface dataset:
Southern Hemisphere baroclinic activity in seasonal forecasts
Authors: Trentini Laura , Calmanti Sandro , Dell’Aquila Alessandro , Gesso Sara Dal , Venturini Marco , Petitta Marcello 
Published: September 2024

Abstract
Accurate prediction of mid-latitude baroclinic activity is extremely relevant for understanding global climate dynamics and improving long-term weather forecasts. However, current seasonal forecast models struggle to accurately represent the variability of baroclinic activity in the Southern Hemisphere, which may affect their reliability and usefulness. Baroclinic instability in the mid-latitudes is a significant component of the climate system, as it is associated with the meridional transport of a large amount of energy and momentum. Therefore, the ability of the models to correctly predict the properties of the atmospheric circulation in this latitudinal region is a very important requirement. The aim of this study is to estimate the energy of atmospheric phenomena typical of the mid-latitudes, such as baroclinic perturbations, and to understand how seasonal forecasts can be practically used to assess the energy transfer in the atmosphere. We compare the Southern Hemisphere mid-latitude winter variability of the seasonal forecasts of the ECMWF, DWD and Météo France forecasting systems with the ERA5 reanalysis. The analysis is performed by computing the Hayashi spectra of the 500-hPa geopotential height field. Both the reanalysis and the seasonal forecast show a series of peaks in the spectral region of eastward-travelling waves, which corresponds to the high frequency and high wavenumber domain. We quantify the amount of energy released from the atmosphere by calculating the Baroclinic Amplitude Index. The results suggest that seasonal forecasts may not accurately capture the variability of geopotential height power spectra in the Southern Hemisphere, which poses a challenge in correctly distributing the energy over spatial and temporal dimensions. This study will show that this problem is particularly pronounced for wavenumber 4 over a period of 8 days. This misrepresentation likely contributes to the uncertainties in precipitation forecasting, with discrepancies exacerbated by a suboptimal description of baroclinic instability and dynamical components in the models. Our findings highlight the need for an improved representation of baroclinic processes in seasonal forecast models, which could lead to substantial advancements in long-term weather prediction capabilities and in a more complete understanding of climate dynamics.
Modelling the Interaction Between Incumbents and New Entrants with a Game Theory Approach: A Case Study of Public Transportation
Authors: Kahrizeh Ali Amiramini , Yazdi Amir Karbassi , Wanke Peter , Tan Yong , Hanne Thomas 
Published: September 2024

AbstractThe transformative influence of new entrants on industries and heightened competition underscores their significance. Mature companies, threatened by their entry, deploy multiple incentives to forestall market penetration. Conversely, consumers embrace fresh participants, creating a dichotomy in reactions. This has spawned escalated conflicts between mature firms and newcomers, rooted in the latter's market entry. This study navigates this landscape by delving into the strategies, preferences, and priorities of these actors, seeking stable equilibrium and reconciliation points for these conflicts. Employing thematic analysis, it distills options, feasible scenarios, and relative preferences of each stakeholder. These insights undergo scrutiny via the GMCR + decision support model. Among 21 conceivable scenarios, the study unveils three equilibria and a semi-stable state, suggesting mature companies recalibrate their stance to explore synergies with new entrants. This research offers a panoramic perspective on the intricate interactions between mature companies and new entrants, transcending the narrow confines of entry barriers.
Revisiting abdominal wall “morbidity” of the extensile anterolateral approach to the thoracolumbar spine
Authors: Theologis Alekos A. , Collins Andrew P. , Parhar Kanwar , Gupta Munish C. 
Published: September 2024

Abstract

Purpose
To assess patients’ perceptions of their abdominal wall following extensile anterolateral approaches to the thoracolumbar spine for adult spinal deformity (ASD) using validated questionnaires.

Methods
Adults who underwent anterior–posterior thoracolumbar spinal operations to the pelvis for ASD in which the anterior fusion was performed through an extensile anterolateral approach were reviewed. Three questionnaires were administered at least 1 year following surgery and included The Abdominal Core Health Quality Collaborative Survey (AHS-QC), The Patient Scar Assessment Scale (PSAS), and The Anterior Abdominal Incision Questionnaire (AAIQ).

Results
Fifty-one patients (80.4% female, median age 65 years) were included. Average follow-up was 2.8 ± 1.7 years. Average number of anterior fusion levels was 3.5 ± 1.4. Patients achieved high satisfaction rates from surgery (74.5%). AAIQ responses included postoperative pain (33.3%), bulging (41.7%), and limitations in daily activities (18.8%) with only 15.7% experienced moderate–severe pain related to their incisions and only 6.3% seeking treatment for their scars. Post-operatively, 63.2% had a neutral or improved self-image of their torso and trunk, while only 10.2% stating it was much worse. Patients’ overall opinion of their scar compared to their normal skin was very positive [average 2.75 ± 2.93 (10 = worst possible scar)]. Favorable scores were also reported for color difference, stiffness, change in thickness, and irregularity in their abdominal scar compared to normal skin.

Conclusions
Following extensile anterolateral approaches to the thoracolumbar spine for ASD, the majority of patients reported mild pain, mild functional limitations, good cosmesis, and high satisfaction rates with their anterior incisions based on validated questionnaires.
Groups, Identity, and Redistributive Preferences in Canada
Authors: Borwein Sophie 
Published: September 2024

AbstractRecent political developments in established democracies have renewed attention to the politics of identity. Some commentators have expressed concern that polities are fracturing along increasingly narrow social identity lines, in the process, losing their ability to build solidarity around shared commitments such as redistribution. This article takes stock of the strength of Canadian social identities and their consequences for redistributive preferences. It asks: first, which group memberships form the basis of Canadians’ perceptions of shared identity, and second, do these group memberships shape preferences for redistribution? This study answers these questions using two conjoint experiments that assess respondents’ perceptions of commonality and support for redistributing to hypothetical Canadians who vary on multiple dimensions of identity and need. Findings support that Canadians perceive greater shared identity with some of their groups (their social class) over others (their region or ascriptive identity), but that they overwhelmingly prioritize redistributing toward those who need it over those with whom they share group memberships.
Federalism and Settler Imperialism: Racial Regimes, Whiteness, and Conquest in Canadian Constitutionalism
Authors: Henderson Phil 
Published: September 2024

AbstractIn political science, federalism is often treated as an “antithesis” to empire. While Canadian Politics has recently become more attentive to the importance of ongoing settler colonialism as conditioning Canadian political life writ large, this has yet to induce a paradigm shift in understanding how the institutional logics of the state were established by, and in order to advance, colonial and imperial ends. This article contributes to this broader understanding by exploring how, in Canada, the federal arrangement congeals a constitutionalized whiteness that facilitates both the internal coherence of a settler class and its subsequent continental expansion. Attentive to the importance of this constitutional development within a world-spanning imperial context, this article also suggests that the simultaneous innovation of Dominion status contoured the early twentieth-century's global colour line, as self-determination was increasingly devolved to other white settler polities. The contradictory realities of these processes are also noted.
When the House is Not a Home: Assessing the Family-Friendliness of Canadian Legislatures
Authors: Johnstone Rachael 
Published: September 2024

AbstractCalls for more family-friendly assemblies, specifically those able to accommodate representatives who are pregnant, postpartum or have young children, have become urgent in the last decade, as a mini-baby boom in the federal parliament and the provinces has called the inclusivity of legislatures into question. Drawing on interviews with legislative clerks, this article asks two questions: 1) Are Canadian legislatures family-friendly? And 2) what approaches to family-friendly legislatures emerge from policies and discussions within these legislatures? It identifies patterns both in the types of changes that are proposed and those which are actioned, finding that changes have leaned heavily on the least consequential improvements. Many calls for change continue to run up against structural challenges that have been, thus far, ignored. Although legislatures are more family-friendly than in previous decades, this article argues that the future of inclusive parliaments hinges on a broad rethinking of the parliamentary role.
Qui paie gagne. Égalité démocratique, inégalités économiques et financement électoral au Canada
Authors: Turmel Patrick , Robichaud David , Mossu Sacha-Emmanuel 
Published: September 2024

RésuméLes instruments auxquels un État peut avoir recours pour atténuer les risques que font peser les inégalités économiques sur la démocratie sont nombreux et peuvent prendre différentes formes. Dans cet article, nous cherchons à mettre en lumière la dimension normative des trois principaux instruments auxquels on a généralement recours pour mitiger l'influence de l'argent dans la compétition électorale, ainsi que le contexte dans lequel ils furent institués, remodelés – et parfois démantelés – au Canada. Ces trois mécanismes sont la limitation des dépenses électorales, le plafonnement des contributions privées et le financement public des partis. Il ne s'agit toutefois pas uniquement de décrire ces instruments, mais de réfléchir aux justifications normatives spécifiques à chacun, et d'en comprendre leur complémentarité. Plus largement, il s'agit d'offrir un cadre pour penser les enjeux de financement électoral en philosophie politique, un sujet trop souvent laissé dans l'ombre par la théorie démocratique.
Generation of Field‐Aligned Currents in Response to Sudden Enhancement of Solar Wind Dynamic Pressure
Authors: Zhang Tian , Ebihara Yusuke , Tanaka Takashi 
Published: September 2024

AbstractWe investigated the generation of field‐aligned currents (FACs) in response to the sudden enhancement of the solar wind dynamic pressure by tracing backward in time a packet of the Alfvén wave in the global magnetohydrodynamic (MHD) simulation. The generation region is identified from three perspectives, including the continuity of the current, the energy conservation and the time rate of change in the FACs. The generation mechanism is found to be related with the tailward motion of the compressional wave, which is excited when the magnetopause is compressed due to the solar wind dynamic pressure pulse. The compressional wave with a high magnetic pressure center interacts with the Earth's dipole field and forms a protruding part of the wavefront near the equatorial plane. The leading edge of the merged magnetic pressure that pertains to the compressional wave and the Earth starts to generate preliminary impulse (PI) FACs off the equator, as the magnetic pressure force accelerates the plasma and magnetic field lines are bent (FAC dynamo 1). Main impulse (MI) FACs are generated behind the leading edge in the equatorial plane due to the enhanced magnetic tension force (FAC dynamo 2). Magnetic field lines would be extremely curved during the passage due to the increasing magnetic tension force. The polarity of PI FACs is decided by the parallel vorticity of plasma flow, and MI FACs are the result of enhanced perpendicular currents together with the plasma flow in the equatorial plane.
The IDH1-R132H mutation aggravates cisplatin-induced acute kidney injury by promoting ferroptosis through disrupting NDUFA1 and FSP1 interaction
Authors: Lai Kunmei , Chen Zhimin , Lin Siyi , Ye Keng , Yuan Ying , Li Guoping , Song Yankun , Ma Huabin , Mak Tak W. , Xu Yanfang 
Published: September 2024

Abstract
The IDH1-R132H mutation is implicated in the development of various tumors. Whether cisplatin, a common chemotherapeutic agent, induces more significant renal toxicity in individuals with the IDH1-R132H mutation remains unclear. In this study, we observed that the IDH1-R132H mutation exacerbates mitochondrial lipid peroxidation and dysfunction in renal tubules, rendering the kidneys more susceptible to cisplatin-induced ferroptosis. The IDH1-R132H mutation increases methylation of the Ndufa1 promoter, thereby suppressing NDUFA1 transcription and translation. This suppression disrupts NDUFA1’s interaction with FSP1, reducing its resistance to cisplatin-induced tubular epithelial cell death. As a consequence, ROS accumulates, lipid peroxidation occurs, and ferroptosis is triggered, thereby promoting acute kidney injury. In summary, this study elucidates a novel mechanism underlying cisplatin-induced nephrotoxicity and provides valuable insights for the development of personalized treatment strategies for tumor patients carrying the IDH1-R132H mutation.
Properties of risk aversion estimated from portfolio weights
Authors: Grant Andrew , Kwon Oh Kang , Satchell Steve 
Published: September 2024

AbstractWhile risk tolerance is often elicited using questionnaire-based instruments, in this paper, we evaluate the merits of an inversion-based technique, wherein risk aversion parameters are inferred from an individual’s portfolio holdings and a sequence of realized returns. We obtain expressions for the finite sample and asymptotic variance of the estimated risk aversion parameter under the inversion approach with a single risky asset, demonstrating that confidence intervals for parameter estimates are relatively wide. Extending the analysis, we show that inferring risk aversion from multiple risky assets does not typically serve to reduce the estimated parameter variance, but rather propagates estimation error.
Potential threats and habitat of the night parrot on the Ngururrpa Indigenous Protected Area
Authors: Sunfly Clifford , Schubert Andrew , Reid Angela M. , Leseberg Nicholas , Parker Luke , Paltridge Rachel 
Published: September 2024

Context The Endangered night parrot (Pezoporus occidentalis) is one of the rarest birds in Australia, with fewer than 20 known to occur in Queensland and, prior to 2020, only occasional detections from a handful of sites in Western Australia (WA). Here, we provide an introduction to night parrots on the Ngururrpa Indigenous Protected Area (IPA) in WA from the perspectives of both Indigenous rangers and scientists working together to understand their ecology. Aims We aimed to identify night parrot sites on the Ngururrpa IPA, compare habitat and likely threats with those in Queensland and identify appropriate management practices. Methods Between 2020 and 2023, we used songmeters (a type of acoustic recorder) to survey for the presence of night parrots at 31 sites (>2 km apart). At sites where parrots were detected, we used camera-traps to survey predators and collected predator scats for dietary analysis. Forty years of Landsat images were examined to assess the threat of fire to roosting habitat. Key results Night parrots were detected at 17 of the 31 sites surveyed on the Ngururrpa IPA. Positive detections were within an area that spanned 160 km from north to south and 90 km from east to west. Ten roosting areas were identified, and these occurred in habitat supporting the same species of spinifex (lanu lanu or bull spinifex, Triodia longiceps) used for roosting in Queensland. However, the surrounding landscapes differ in their vegetation types and inherent flammability, indicating that fire is likely to be a more significant threat to night parrots in the Great Sandy Desert than in Queensland. Dingoes (Canis dingo) were the predator species detected most frequently in night parrot roosting habitat and the feral cat was found to be a staple prey for dingoes at night parrot sites. Conclusions Our surveys indicated that there could be at least 50 night parrots on the Ngururrpa IPA, which is the largest known population in the world. Fire is a key threat to roosting habitat, occurring in the surrounding sandplain country every 6–10 years. Dingoes are common in night parrot habitat and regularly eat feral cats, which are only occasionally detected in roosting habitat. Implications We recommend management that focuses on strategic burning to reduce fuel loads in the surrounding landscape, and limiting predator control to methods that do not harm dingoes.
Theoretical study of particle and energy balance equations in locally bounded plasmas
Authors: JUN Hyun-Su , TSANG Yat Fung , YOO Jae Ok , SINGH Navab 
Published: September 2024

Abstract
In this study, new particle and energy balance equations have been developed to predict the electron temperature and density in locally bounded plasmas. Classical particle and energy balance equations assume that all plasma within a reactor is completely confined only by the reactor walls. However, in industrial plasma reactors for semiconductor manufacturing, the plasma is partially confined by internal reactor structures. We predict the effect of the open boundary area (

) and ion escape velocity (

) on electron temperature and density by developing new particle and energy balance equations. Theoretically, we found a low ion escape velocity (

/

) and high open boundary area (

) to result in an approximately 38% increase in electron density and an 8% decrease in electron temperature compared to values in a fully bounded reactor. Additionally, we suggest that the velocity of ions passing through the open boundary should exceed

under the condition

.
Association Between Cardiorespiratory Fitness and Trend of Age-Related Rise in Arterial Stiffness in Individuals With and Without Hypertension or Diabetes
Authors: Jae Sae Young , Lee Kyung Hyun , Kim Hyun Jeong , Kunutsor Setor K , Pierce Gary L , Hui Stanley Sai-Chuen , Kang Mira 
Published: September 2024

Abstract

BACKGROUND
This study aimed to investigate whether higher cardiorespiratory fitness (CRF) can modify the trend of age-related rise in arterial stiffness in individuals with and without hypertension (HTN) or diabetes.

METHODS
The study included 4,935 participants who underwent maximal cardiopulmonary exercise testing with respiratory gas analysis in a health screening program. CRF was directly measured using peak oxygen uptake during the cardiopulmonary exercise test, while arterial stiffness was evaluated using brachial–ankle pulse wave velocity (baPWV).

RESULTS
Participants with high CRF levels had significantly lower baPWV compared with those with low CRF levels, regardless of HTN or diabetes status (P &lt; 0.05). The trend of baPWV increased with age, but the rate of age-related increase in baPWV was lower in individuals with moderate-to-high CRF levels compared with those with low CRF levels, regardless of HTN or diabetes status. Joint association analysis indicated that the trend of age-related increase in baPWV was the lowest in fit individuals without HTN or diabetes compared with unfit individuals with HTN or diabetes (P &lt; 0.01). However, the trend of age-related increase in baPWV was not attenuated in fit with HTN or diabetes compared with unfit with HTN or diabetes.

CONCLUSIONS
These findings suggest that higher CRF levels may mitigate the trend of age-related rise in arterial stiffness in individuals with and without HTN or diabetes. However, this attenuating trend appears more pronounced in individuals without HTN or diabetes.
Functional landscape of genome-wide postzygotic somatic mutations between monozygotic twins
Authors: Yamamoto Kenichi , Lee Yoko , Masuda Tatsuo , Ozono Keiichi , Iwatani Yoshinori , Watanabe Mikio , Okada Yukinori , Sakai Norio 
Published: September 2024

Abstract
Monozygotic (MZ) twins originate from a single fertilized egg, making them genetically identical at the time of conception. However, postzygotic somatic mutations (PZMs) can introduce genetic differences after separation. Although whole-genome sequencing (WGS) sheds light on somatic mutations in cancer genomics, its application in genomic studies of MZ twins remains limited. In this study, we investigate PZMs in 30 healthy MZ twin pairs from the Osaka University Center for Twin Research using WGS (average depth = 23.8) and a robust germline-calling algorithm. We find high genotype concordance rates (exceeding 99%) in MZ twins. We observe an enrichment of PZMs with variant allele frequency around 0.5 in twins with highly concordant genotypes. These PZMs accumulate more frequently in non-coding regions compared with protein-coding regions, which could potentially influence gene expression. No significant association is observed between the number of PZMs and age or sex. Direct sequencing confirms a missense mutation in the ANKRD35 gene among the PZMs. By applying a genome-wide mutational signature pattern technique, we detect an age-related clock-like signature in these early postzygotic somatic mutations in MZ twins. Our study provides insights that contribute to a deeper understanding of genetic variation in MZ twins.
Etrasimod Corticosteroid-Free Efficacy, Impact of Concomitant Corticosteroids on Efficacy and Safety, and Corticosteroid-Sparing Effect in UC: Analyses of the ELEVATE UC Clinical Programme
Authors: Sands Bruce E , Leung Yvette , Rubin David T , Gecse Krisztina B , Panés Julian , Goetsch Martina , Wang Wenjin , Woolcott John C , Smith Christina C , Wosik Karolina , Schreiber Stefan 
Published: September 2024

Abstract

Background
Etrasimod is an oral, once-daily, selective sphingosine 1-phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). This post hoc analysis reports efficacy and safety by baseline corticosteroid use in the ELEVATE UC clinical programme.

Methods
Patients with UC received etrasimod 2 mg or placebo for up to 52 weeks. Corticosteroid use was permitted; tapering was recommended from Week 12. Efficacy was assessed at Weeks 12 and 52 in ELEVATE UC 52, and Week 12 in ELEVATE UC 12, in patients in the corticosteroid (CS) and no-CS subgroups. CS-free efficacy at Week 52 was assessed in patients with baseline CS use.

Results
In ELEVATE UC 52 and ELEVATE UC 12, 93/289 (32.2%) and 65/238 (27.3%) patients receiving etrasimod and 42/144 (29.2%) and 34/116 (29.3%) patients receiving placebo, respectively, had concomitant CS use at baseline. In the CS and no-CS subgroups, higher proportions of patients who received etrasimod vs placebo achieved clinical remission (p &lt; 0.05) in ELEVATE UC 52 at Weeks 12 (CS: 32.3% vs 16.7%; no-CS: 26.0% vs 4.9%) and 52 (CS: 31.2% vs 9.5%; no-CS: 33.2% vs 6.9%). In the CS subgroup, significantly more patients receiving etrasimod than placebo achieved CS-free clinical remission at Week 52 (31.2% vs 7.1%). No increases in infection rates were observed with baseline CS use. Safety was comparable between subgroups.

Conclusions
Etrasimod demonstrated efficacy in inducing and maintaining remission in both subgroups. CSfree remission was achieved in the CS subgroup. Safety was consistent, with no increase in infections.