bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Metastasectomy in the Multimodality Approach for BRAF V600E Metastatic Colorectal Cancer: The Mayo Clinic Experience
Authors: Johnson Benny , Jin Zhaohui , Truty Mark J. , Smoot Rory L. , Nagorney David M. , Kendrick Michael L. , Kipp Benjamin R. , Grothey Axel 
Published: September 2017

Abstract

Background
BRAF V600E mutations are present in 8%–10% of patients with metastatic colorectal cancer (mCRC) and portend poor prognosis. This study investigated the impact of metastasectomy for patients with BRAF V600E mCRC.

Subjects, Materials, and Methods
Using prospective clinical and molecular data, patients with BRAF V600E mCRC were analyzed for clinical characteristics and survival. Statistical analyses utilized the Kaplan-Meier method, log-rank test, and Cox proportional hazard models.

Results
Fifty-two patients were identified between July 1, 2008, and January 4, 2016. Patient characteristics included median age 65 years, 61% female, Eastern Cooperative Oncology Group performance status ≤1, 71% with right-sided tumors, and 28% with liver-limited metastasis. In the first-line setting, 7% (4/52) received fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI)/bevacizumab (BEV) and 81% were treated with doublet chemotherapy consisting of fluoropyrimidine, oxaliplatin, and BEV. Median overall survival (OS) for all 52 patients was 25 months with median progression-free survival (PFS) of 9.3 months. With median follow-up of 18.3 months, 21 patients underwent metastasectomy with longer OS (29.1 months vs. 22.7 months, hazard ratio [HR] = 0.33; confidence interval [CI], 0.12–0.78; p = .01) and PFS (13.6 months vs. 6.2 months, HR = 0.53, CI, 0.28–0.97; p = .03) compared with the non-metastasectomy cohort. In multivariate analysis, metastasectomy remained significant for improved survival outcomes (HR = 0.52; 95% CI, 0.07–1.02; p = .02). Median disease-free survival after metastasectomy was 9.7 months (95% CI, 5.5–19.5). Two patients remain disease-free at the time of last follow-up, with one patient without relapse for greater than 2 years (28.9 months).

Conclusion
Multimodality therapy incorporating metastasectomy for BRAF V600E mCRC should be considered and might be associated with improved overall survival in select patients.

Implications for Practice
BRAF V600E metastatic colorectal cancer (mCRC) represents an extremely difficult molecular subset of colorectal cancer to treat. To date, this subset remains refractory to standard chemotherapies, prompting extensive clinical investigation regarding novel treatment approaches and targeted modalities. While the use of metastasectomy for expanded RAS wild-type and RAS mutated mCRC has resulted in improved overall survival for select patients, utilization of metastasectomy in patients with BRAF V600E mCRC remains controversial. This article explores the authors' experience with BRAF V600E mCRC to ascertain whether a multidisciplinary approach incorporating metastasectomy for well-selected patients improves overall survival.
Protagonismo na aprendizagem de línguas pelo uso de aplicativos
Authors: Garcia Marilene Santana dos Santos , Machado Dinamara P 
Published: September 2017

O presente artigo representa parte de pesquisa realizada em nível de pós-doutorado entre 2014 e 2016, cujo objetivo principal foi, a partir de diferentes perspectivas de análise, levantar e discutir os diferenciais de aprendizagem de línguas por meio do uso de aplicativos. Uma dessas perspectivas é tratada neste artigo, por meio dela apontam-se especificamente alguns resultados da análise qualitativa realizada em quatro aplicativos, visando avaliar as soluções de design, das atividades propostas, das interfaces, das formas de usabilidade, de estímulo à aprendizagem e ferramentas, entre outros aspectos, sinalizando para competências e habilidades necessárias aos aprendizes para o protagonismo na aprendizagem. Palavras-chave: Aplicativos, Aprendizagem autônoma, Mobile-learning, Aprendizagem híbrida, Objetos de aprendizagem mobile.Protagonism in Languages Learning through the Use of ApplicationsAbstract This article is an excerpt from a postdoctoral research study, between 2014 and 2016, which the main objective was, from different perspectives of analysis, to raise and discuss the differentials of language learning through the use of apps. One of these perspectives is presented in this article, which specifically identifies some results of the qualitative analysis carried out in four applications, aiming at evaluating design solutions, proposed activities,interfaces, usability forms, learning stimulus, learning tools, among otheraspects, signaling to the skills and abilities of the apprentices necessary for the protagonism in the learning.Keywords: Applications, Autonomous learning, Mobile-learning, Hybrid learning, Digital learning objects
Editorial
Authors: Santos Gildenir Carolino 
Published: September 2017

É com muito prazer que damos continuidade à festividade dos 10 anos de existência da ETD – uma das primeiras revistas eletrônicas indexadas do país na década de 90. Para comemorar estes dez anos, apresentamos um novo formato do design da revista e também a reunião de trabalhos de vários pesquisadores de diversas áreas geográficas do Brasil. Nesses 10 anos, iremos celebrar, ao longo do ano de 2010, lançando edições comemorativas organizadas e/ou compostas por trabalhos de grande relevância acadêmica. O empenho em obtermos Qualis A, nos últimos anos, contou com a colaboração de conceituados pesquisadores brasileiros e estrangeiros, aos quais seremos sempre gratos: a confiança que tiveram e têm na ETD nos permitiu saltar de Qualis C em Educação para A, em 2007. Esse esforço, devidamente orquestrado, trouxe frutos.
Patrimônio em movimento: considerações sobre o mundo rural paulista
Authors: Pellicciotta Mirza 
Published: September 2017

Este artigo procura refletir brevemente sobre a trajetória de constituição e transformação do território paulista entre os séculos XVI e XXI na busca e contribuir para a identificação e reconhecimento de diferentes paisagens culturais, gestadas em recortes de tempo e espaço específicos e que ainda hoje guardam testemunhos inestimáveis do patrimônio rural paulista. O artigo procura também traçar algumas considerações sobre as fazendas integrantes do projeto Fazendas Históricas Paulistas.
Em busca do patrimônio intangível: dificuldades, estratégias e caminhos para a reconstrução do patrimônio imaterial das fazendas históricas paulistas
Authors: Von Simson Olga Rodrigues de Moraes 
Published: September 2017

Depois de reconstruir o processo de constituição da noção de patrimônio intangível ou imaterial em nosso país, mostrando os principais estudiosos que buscaram sua construção, registro e a inserção dessa preocupação na Constituição de 1988, o texto busca mostrar como o projeto Fazendas Históricas Paulistas vem trabalhando essa questão, ao tentar reconstruir o patrimônio imaterial de cada fazenda, através de depoimentos orais colhidos com proprietários e/ou trabalhadores que vivem há muito tempo na propriedade.
Konsep pendidikan Islam KH Abdullah bin Nuh dan Relevansinya Dengan Pendidikan Islam Modern
Authors: Mahfudin Rudi , Wajdi Firdaus , Ismail Yusuf 
Published: September 2017

KH Abdullah bin Nuh is one of Nusantaraâ€™s scholar who has a significant role in Islamic education. Beside that, he is also concerned with the improvement of Islamic education in Indonesia and vigorously wrote about education. The objective of this research is to increase insight about Islamic education of KH. Abdullah bin Nuh in order to recommend it as reference and to make it applicable with current Islamic education in Indonesia. This proves that KH. Abdullah bin Nuhâ€™s thoughts on Islamic education remain relevant to discuss and probably could become alternative recommandation to the development of Indonesian Islamic education.
Keywords: Islamic Education, KH. Abdullah bi Nuh, Islamic Modern Education
Abstrak
KH Abdullah bin Nuh merupakan salah satu ulama Nusantara dan yang sangat berpengaruh di dalam dunia pendidikan Islam. Selain aktif menulis dan berkarya KH Abdullah bin Nuh juga sangat memperhatikan perkembangan pendidikan Islam di Indonesia. Tujuan penulisan skripsi ini adalah untuk menambah wawasan dan khazanah mengenai konsep pendidikan Islam KH Abdullah bin Nuh, agar konsep pendidikan Islam bisa dijadikan acuan dan dapat dikombinasi dengan pendidikan Islam yang sudah ada di Indonesia. Dan membuktikan bahwa konsep pendidikan Islam KH Abdullah bin Nuh masih relevan untuk dibahas dan mungkin dapat digunakan sebagai pedoman konsep pendidikan Islam Indonesia.
Kata Kunci : Konsep Pendidikan Islam, KH Abdullah bin Nuh, Pendidikan Islam Modern
Meta‐Analysis Constrained by Data: Recommendations to Improve Relevance of Nutrient Management Research
Authors: Eagle Alison J. , Christianson Laura E. , Cook Rachel L. , Harmel R. Daren , Miguez Fernando E. , Qian Song S. , Ruiz Diaz Dorivar A. 
Published: September 2017

Core Ideas
Data and reporting deficiencies reduce the effectiveness of agri‐environmental meta‐analysis.
Standardization and consistency across studies will enhance data synthesis and meta‐analysis.
Reporting standard sets of data and meta‐data will extend the value of agricultural field research.
Five research teams identified parallel obstacles when concurrently attempting to conduct meta‐analyses on the air and water quality impacts of on‐farm 4R nutrient management practices. Across projects, system complexity and the lack of relevant data from cultivated and grassland agriculture field trials impeded the application of standard meta‐analytical procedures. Because challenges were comparable across projects, the 4R Research Fund technical leadership tasked the researchers with recommending improvements in field research design, data collection, and reporting to enhance future agri‐environmental data syntheses and meta‐analyses. Here we outline statistical and analytical issues unique to meta‐analysis and data synthesis in agriculture, discuss critical data and reporting gaps in the existing literature, and provide specific recommendations for researchers, funders, and journals. Key obstacles developed when field studies did not include complete descriptive or response data (per treatment and experiment year), measurement uncertainty, estimation error in treatment effects, or simultaneously measured nutrient losses and crop yield. Others did not report crop nutrient uptake or their apparent recovery efficiencies. To alleviate such challenges for subsequent research, we make the following recommendations: (i) use common meta‐data protocols for consistent units and terminology; (ii) clearly define treatments and controls; (iii) provide complete, tabular, full‐factorial response data for each year and location; (iv) collect and report a minimum set of auxiliary data; and (v) establish requirements for data curation and repositories in funding and publication cycles. Implementing these in future nutrient management research will facilitate more robust meta‐analyses and other data synthesis efforts.
Penggunaan Earned Value Analysis Di Dalam Mengukur Kinerja IT Project
Authors: Lisanti Yuliana 
Published: September 2017

IT Project’s succesfulness can be measured from some factors such as project’s time completion, project’s cost and project’s quality. These 3 factors, at least should be as planned, means that on time, on budget and on quality, or better than it has agreed. That’s why a regular project progress update has become a very important factor because it can be used by management to control the project, as well as an alert mechanism or early warning sign whether or not the project is on track or off track. This paper adopts the earned value analysis (EVA) that is used to monitor IT project progress, because EVA is a simple formula whilst able to provide a comprehensive information to support decision making.
Model System Dynamics Infrastruktur BTS Ramah Lingkungan Daerah Rural untuk Optimalisasi Perhitungan ARPU
Authors: Sardjono Wahyu 
Published: September 2017

Green Base transceiver station (BTS) or known as remote BTS is a special BTS with IP technology-based that has a small capacity and takes low power consumption with standard features suitable for use in rural areas. BTS utilizes 100% solar energy as a source of energy. The infrastructure Green BTS is composed of high-tech devices which is able to save energy, environmentally friendly, small and lightweight. The high rate service calls and SMS on green BTS is caused by the absence of competition telecom operators at a site. The solution to this problem needs to be done with system dynamics modeling approach with the aim to establish causality (cause and effect) between the variables. The standard target of model pattern which has been changed on system dynamics can be used to demonstrate the behavior of the model between the number of subscribers, the availability of network capacity and ARPU (average revenue per user) on the Green BTS site. On the changed standard target model, the actual revenue is placed as the actual event, the target revenue is as a target; the difference between the actual and target revenue is as gap, gap changes are as the pressure on the target and the corrective action taken against revenue as a corrective action. Based on simulation results, the standard model change targets can be developed by adding two negative loops (balancing loop) as an alternative solution towards the achievement of revenue targets that have been set.
Pembangunan Model Restaurant Management System
Authors: Jingga Fredy , Limantara Natalia 
Published: September 2017

Model design for Restaurant Management System aims to help in restaurant business process, where Restaurant Management System (RMS) help the waitress and chef could interact each other without paper limitation. This Restaurant Management System Model develop using Agile Methodology and developed based on PHP Programming Langguage. The database management system is using MySQL. This web-based application model will enable the waitress and the chef to interact in realtime, from the time they accept the customer order until the chef could know what to cook and checklist for the waitress wheter the order is fullfill or not, until the cahsier that will calculate the bill and the payment that they accep from the customer.
Pemodelan Tingkat Penghunian Kamar Hotel di Kendari dengan Transformasi Wavelet Kontinu dan Partial Least Squares
Authors: Ohyver Margaretha , Pudjihastuti Herena 
Published: September 2017

Multicollinearity and outliers are the common problems when estimating regression model. Multicollinearitiy occurs when there are high correlations among predictor variables, leading to difficulties in separating the effects of each independent variable on the response variable. While, if outliers are present in the data to be analyzed, then the assumption of normality in the regression will be violated and the results of the analysis may be incorrect or misleading. Both of these cases occurred in the data on room occupancy rate of hotels in Kendari. The purpose of this study is to find a model for the data that is free of multicollinearity and outliers and to determine the factors that affect the level of room occupancy hotels in Kendari. The method used is Continuous Wavelet Transformation and Partial Least Squares. The result of this research is a regression model that is free of multicollinearity and a pattern of data that resolved the present of outliers.
Analisis Kesulitan Mahasiswa Sastra China dalam Menguasai Hanzi (Studi Kasus di Universitas Bina Nusantara, Darma Persada dan Kristen Indonesia)
Authors: Tjong Cendrawaty 
Published: September 2017

Hanzi is the written form of the Chinese language. It is one of ancient characters in the world and also is the most used letters now. Many university students think that hanzi is their main problem in learning Chinese language. In order to find the easiest way to master Chinese characters, the author conducted a study using qualitative and quantitative methods by conducting surveys to universities, distributing questionnaires, doing a Chinese hanzi skill test, doing interviews with lecturers who teach hanzi course, and making an experiment according to the theory of hanzi expert in China. The results show that the difficulty of university students to master hanzi is divided to several parts, such as: the difficulty from the elements of hanzi, poor learning habits, the thought of students or lecturer who thought that hanzi is difficult, lack of motivation and lack of language environment. The results also show the the good methods to teach hanzi is not only focused on textbook or writing rules, but also can teach knowledge or theories relating to, as well as providing, cultural knowledge contained in it.
Prinsip Belajar Mengajar dalam Analekta yang Terkandung pada Film Kungfu Panda dan Kungfu Panda 2
Authors: Sufianto Agustinus , Patricia Patricia 
Published: September 2017

The Analects is one of the famous books from China which records Confucius’ teachings. Kungfu Panda and Kungfu Panda 2 are two famous animation films from America. After seeing these movies, there are some similar values that can be found between the movies and The Analects, especially in education field. The writer limited the scope into teaching and learning principles. The writer defined 2 main issues. First is to explain the correlation between Kungfu Panda and Kungfu Panda’s teaching and learning principles with The Analects. Second is to understand those principles and its application in our daily lives. This research method is library research. The results stated that there are some correlation between Kungfu Panda, Kungfu Panda 2, and The Analects. Analyzing the correlation will help us to understand more about Confucius’ teaching, especially in education field.
Berpikir dan Berperilaku dengan Rasa
Authors: Homan Devi Kurniawati 
Published: September 2017

Article discusses the importance for a designer to understand about psychology and consumers’ behaviors that act based on their feelings. Human as a complicated living creature has lot of feelings before making a reaction. The reaction itself is based on their own feeling from their experiences or the others’ before. In our daily life, we think a lot based on our feelings. We associate a stimulus with an unconscious physical or emotional response. A designer often needs to make a promotion, branding, and campaign for a product or something else. So, it is important for designers to know their targets and behaviors. By understanding their target behaviors, it is easier to predict or to design the reaction and response when the product or campaign is launched. The understanding of the psychology study is important for a designer as well as understanding the other branch of study beside their own study about aesthetics. When the designer understands a lot of things, they can make a creative, good and useful visual communication.
Stereotip Gender dan Dominasi Kapitalis dalam Iklan Televisi suatu Analisis Wacana Kritis Terhadap Iklan Televisi Citra Korporasi Gudang Garam di Bulan Ramadhan
Authors: Wahyuningtyas Bhernadetta Pravita , Setiowati Endang 
Published: September 2017

Advertising has many purposes including the formation of consciousness, creating the image of the product or brand, forming positive associations and encouraging consumer behavior. Basically, the purpose of advertising is to achieve economic hegemony of the producers of goods or service advertised. Ads are increasingly being used for the benefit of the capitalists. Corporate advertising researchers usually discuss the effects of advertising on the form of company image only. But this research is not going to reveal about the image of a company that advertised, but about the creator ideology behind the creation of a corporate Advertising. The corporate Ads examined in this study is a series of Gudang Garam corporate advertisement which consists of two ads that aired on television every Ramadan. The research method used is French critical discourse analysis and analytical method of Sara Mill. This study uses substantive theoretical framework such as hegemony, ideology, patriarchy, and Marxist feminism and the discourse analysis theory from Michael Foucault and semiotic theory of Roland Barthes. The results of this study showed that the ideology of the ad creator which is very patriarchal makes the text of the Gudang Garam corporate ads aired on all television stations every Ramadan, was laden with the existence of gender stereotypes.
Gambaran Disonansi Kognitif pada Wanita Perokok Dewasa Muda Berpendidikan Tinggi
Authors: Fitri Rani Agias 
Published: September 2017

This research aims to get the description of cognitive dissonance of high educated young adult smoker women, such as the source of dissonance and how to lessen their dissonance. By qualitative research method through depth interview with four research subjects, it is found out that logical inconsistency, general opinion, and past experience are the source of dissonance. Culture norm becomes the source of dissonance only on three subjects. The way the four subjects lessen their cognitive dissonance are changing behavior element and increasing cognitive element whereas changing cognitive element is only done by one subject.
Analisis Kesesuaian Penggunaan Bahan Ajar Bahasa Mandarin Sekolah Menengah Umum dengan Ketetapan Badan Standar Nasional Pendidikan
Authors: Haryanti Sri 
Published: September 2017

Teaching material is the important component in teaching and learning process, therefore, choosing the correct one will make easy the achievement of the learning objective. The Education National Standard Foundation (Badan Standar Nasional Pendidikan) arranges the basic competence standard which will be achieved in learning process as well as the topics which must be covered in the given teaching material. Every education stage has different material, and it is also different for the learner in different study program who will have different teaching material which is in accordance with the field of study and the expected goal. To achieve the good learning objective, the teacher has right to choose the textbook which is going to be used in the learning activities. However, there are also some schools decide to cooperate with other course institutions in running the Mandarin Language teaching and learning activities. The limitation of the availabality of Mandarin textbook which uses Indonesian language gives certain difficulty to the learners not only for the learning activity but also for the process of transferring the knowledge. The writer tries to describe the teaching material used by Senior High School and to see whether that textbook has fulfilled basic competence standard criteria which is going to be achieved by using discussion method with Senior High Schools teachers. It also tries to enlighten the material inside the textbook which is used by the teacher. The writer hopes there will be Mandarin Language Textbook which meets the basic competence standard which is able to support the learners in order to achieve the objective of the Mandarin Language learning process in Senior High School.