bluuebunny/crossref_metadata_2025_split huggingface dataset:
BTB-autograft for mini open ACL replacement
Authors: Thomas Wolfram , Thomas Sascha , Walter Sebastian 
Published: March 2016

Aims and Objectives: This study intended to develop a new surgical approach combining easy operative handling as well as high functional outcomes for the reconstruction of the ACL. Materials and Methods: For the substitution of the ACL we use a Bone-tendon-bone auto-graft. After resecting the transplant from its original position and the mobilization of the Hoffa body the surgeon has an optimal sight onto the site of damage. During the whole intervention, the joint capsule is not resected. Results: In the time between September 2009 and January 2012 we treated 24 consecutive patients using this approach. Patients were evaluated using the Lysholm and the IKDC Score. Before the intervention patients scored 48, 6 ± 7, 4 resp. 43, 0 ± 4,8. After 36 months patients’score improved to 97, 1 ± 2, 6 resp. 96, 8 ± 2, 4; p = 0,037). Conclusion: Easy handling and precise placement of the graft demand the consideration of this technique as a standard treatment option.
Radiostereometric Evaluation of Tendon Elongation after Distal Biceps Repair
Authors: Marshall Nathan , Keller Robert A. , Guest John-Michael , Moutzouros Vasilios 
Published: March 2016

Objectives: Operative repair of distal biceps tendon ruptures have shown successful outcomes. However, little is known about the amount of tendon or repair site lengthening or creep. Treatment algorithms in regards to repair fixation, immobilization, initiation of activity and physical therapy are largely made on previous tendon healing principles and anecdotal findings. The purpose of our study was to evaluate distal biceps tendon repair via intratendinous radiostereometric analysis to evaluate tendon lengthening/creep at different time intervals of healing. Methods: Ten patients were recruited who sustained a distal biceps rupture requiring operative repair. Distal biceps repairs were performed using an endobutton only, single incision technique. Intraoperatively, two 2-mm tantalum beads with laser-etched holes were sutured to the distal biceps tendon. One bead was placed at the radius tendon interface and the other placed 1cm proximal to the first bead. Beads were evaluated via both CT scans immediately post-operatively and at 16 weeks and x-rays obtained at time 0 and then at 4, 8, and 16 weeks. Measurements were made using the endobutton to bead and bead-to-bead distances in order to assess repair site elongation as well as tendon elongation over time. Following final follow-up, patients underwent a DASH questionnaire and ultrasound to confirm the integrity of the tendon. Results: Ten patients were included in the study. Nine patients had complete ruptures with one having a partial rupture that underwent completion and subsequent repair. All patients showed statistically significant lengthening after surgery. The mean amount of lengthening after surgery was 21.8 mm (range 10.1-29.7 mm, p < 0.05). The repair site lengthened a mean of 12.5 mm (range 8.8-17.0 mm, p <0.05) and the tendon lengthened a mean of 9.4 mm (range: 4.0-18.8 mm, p<0.05) from surgery to final follow-up. The greatest change in lengthening was noted between time 0 and week 4 (mean: 11.8 mm, range: 4.0-18.0 mm, p<0.05), with the least amount of lengthening between week 8 and week 16 (mean: 3.6 mm, range: 2.1-5.5 mm, p<0.05). Average DASH scores after surgery was 4.5 (range: 2.5-16.7). Final ultrasound evaluations found no re-ruptures in any of the patients. Conclusion: This study’s findings suggest that all patients undergoing distal biceps tendon repair have significant elongation of their repair site and tendon after surgery, with the greatest amount of lengthening seen in the early post-operative period. These findings lend insight into decision-making with regards to intraoperative repair fixation and post-operative activity protocols while also adding knowledge to overall tendon repair principles.
Lacertus Fibrosis versus Achilles Allograft reconstruction for Chronic Distal Biceps Tears
Authors: Ramirez Miguel , Murthi Anand 
Published: March 2016

Objectives: Chronic distal biceps tears can be difficult to treat as in many cases, the remaining biceps tendon is significantly retracted and an allograft may be required to provide length for reconstruction. The lacertus fibrosis (LF), being a local, stout, fibrous sheath, can potentially be used as a reconstruction graft, obviating the need for allograft tissue. The purpose of this study is to evaluate the strength of the lacertus fibrosis compared to achilles allograft (AA) for distal biceps reconstruction. Methods: 10 fresh-frozen matched cadaveric pairs of elbows were used in this study. The distal biceps tendon was isolated and 3 centimeters of tendon was resected. In Group 1, the LF was identified and released from its distal attachment, maintaining its attachment to the biceps muscle. This was then tubularized and repaired to the radius via button fixation. In Group 2, an AA tendon graft was sutured to the biceps muscle via Pulvertaft weave and similarly repaired to the ulna via button fixation. The prepared radii were rigidly mounted at a 45-degree angle in a MTS electromechanical test frame (MTS Systems, Eden Prairie, MN). The proximal biceps muscle was secured in a custom fabricated cryogenic grip and allowed to freeze for 60s prior to testing. Two differential variable reluctance transducers (DVRTs) were mounted on the specimens, one at the radius-soft tissue junction and the second in the muscle or muscle allograft tissue junction proximal to the repair. Specimens were then loaded at a displacement rate of 20 mm/min until failure. Failure was defined as a 3 mm displacement of the DVRT located at the radius-soft tissue junction. Stiffness was calculated from the initial linear portion of the load versus radial DVRT curve. A t-test was used to determine if any observed differences were significant (p≤0.05) Results: Load to failure, as defined as a 3mm gap formation by DVRT was similar between both groups. Load to failure in Group 1 (LF) was 20.17 ± 5.52 N versus 16.89 ±4.54 N in Group 2 (AA) (p=0.18). Stiffness of the construct was also not statistically different, with Group 1 (LF) averaging 12.32± 7.11 KPa versus 10.48 ± 5.66 KPa in Group 2 (AA) (p=0.34). Conclusion: Lacertus fibrosis reconstruction for chronic distal biceps tears was as strong biomechanically as the commonly used achilles tendon allograft in terms of load to failure and construct stiffness. This may be a reasonable alternative for chronic distal biceps reconstruction in which primary repair is not possible.
A transplant “immunome” screening platform defines a targetable epitope fingerprint of multiple myeloma
Authors: Schieferdecker Aneta , Oberle Anna , Thiele Benjamin , Hofmann Fabian , Göthel Markus , Miethe Sebastian , Hust Michael , Braig Friederike , Voigt Mareike , von Pein Ute-Marie , Koch-Nolte Friedrich , Haag Friedrich , Alawi Malik , Indenbirken Daniela , Grundhoff Adam , Bokemeyer Carsten , Bacher Ulrike , Kröger Nicolaus , Binder Mascha 
Published: March 2016

Key Points
The myeloma transplant B-cell immunome is predictive for response to treatment. It may be exploited by immunosequencing and library technology as a source for unique target structures and antibodies for immunotherapy.
Biosafety of biotechnologically important microalgae: intrinsic suicide switch implementation in cyanobacterium Synechocystis sp. PCC 6803
Authors: Čelešnik Helena , Tanšek Anja , Tahirović Aneja , Vižintin Angelika , Mustar Jernej , Vidmar Vita , Dolinar Marko 
Published: March 2016

ABSTRACT
In recent years, photosynthetic autotrophic cyanobacteria have attracted interest for biotechnological applications for sustainable production of valuable metabolites. Although biosafety issues can have a great impact on public acceptance of cyanobacterial biotechnology, biosafety of genetically modified cyanobacteria has remained largely unexplored. We set out to incorporate biocontainment systems in the model cyanobacterium Synechocystis sp. PCC 6803. Plasmid-encoded safeguards were constructed using the nonspecific nuclease NucA from Anabaena combined with different metal-ion inducible promoters. In this manner, conditional lethality was dependent on intracellular DNA degradation for regulated autokilling as well as preclusion of horizontal gene transfer. In cells carrying the suicide switch comprising the nucA gene fused to a variant of the copM promoter, efficient inducible autokilling was elicited. Parallel to nuclease-based safeguards, cyanobacterial toxin/antitoxin (TA) modules were examined in biosafety switches. Rewiring of Synechocystis TA pairs ssr1114/slr0664 and slr6101/slr6100 for conditional lethality using metal-ion responsive promoters resulted in reduced growth, rather than cell killing, suggesting cells could cope with elevated toxin levels. Overall, promoter properties and translation efficiency influenced the efficacy of biocontainment systems. Several metal-ion promoters were tested in the context of safeguards, and selected promoters, including a nrsB variant, were characterized by beta-galactosidase reporter assay.
Individuals With Disabilities Who Have Diabetes: Do We Have Targeted Interventions?
Authors: Comer-HaGans DeLawnia , Austin Shamly , Ramamonjiarivelo Zo 
Published: March 2016

Abstract
According to 2010 data from the Centers for Disease Control and Prevention (CDC), diabetes is the seventh leading cause of death in the United States. It is assumed that various diabetes interventions are available to help individuals manage this chronic disease, but that is not the case. The literature is scant regarding interventions focused on people with disabilities who have diabetes. The purpose of this article is to review interventions specifically focused on people with disabilities who have diabetes and to discuss the effect of these interventions on this population.
From Nonissue to Healthcare Crisis: A Historical Review of Aging and Dying With an Intellectual and Developmental Disability
Authors: McGinley Jacqueline M. 
Published: March 2016

Abstract
Individuals with intellectual and developmental disabilities are living unprecedentedly longer lives primarily due to the long-term benefits of the deinstitutionalization movement and widespread improvements in health outcomes. However, the consequences of this protracted aging process are significant, complex, and often poor not only for the individuals and their caregivers but for the mainstream healthcare community. This article will explore, utilizing a constructionist perspective, how these challenges evolved from a nonissue to an impending crisis in less than 25 years. Additionally, present-day efforts by researchers, policymakers, and practitioners to address these challenges will be explored and recommendations will be made for future directions.
Why Realists Need Tropes
Authors: Keinänen Markku , Hakkarainen Jani , Keskinen Antti 
Published: March 2016

AbstractWe argue that if one wishes to be a realist, one should adopt a realist ontology involving tropes instead of a Russellian ontology of property universals and objects. Either Russellian realists should adopt relata-specific relational tropes of instantiation instead of facts, or, better, convert to Neo-Aristotelian realism with monadic tropes. Regarding Neo-Aristotelian realism, we have two novel points why it fares better than Russellian realism. (1) Instantiation of property universals by tropes, and characterisation or inherence between tropes and objects, are more transparent ontological notions than relational inherence, which is assumed in Russellian realism with the relational tropes of instantiation. (2) Neo-Aristotelian realism makes better sense about abstract universals, which are a more viable option than concrete universals.
Speeding of α Decay in Strong Laser Fields
Authors: Mişicu Ş , Rizea M. 
Published: March 2016

Abstract
An extremely high-intensity laser interaction with a nucleus that is undergoing spontaneous α-decay is investigated in the framework of the time-dependent one-body Schrödinger equation solved by a Crank-Nicolson scheme associated with transparent boundary conditions. The wave-packet dynamics are determined for various laser intensities and frequencies for continuous waves and for sequences of few-cycle pulses. We show that pulse sequences containing an odd number of half-cycles determine an enhancement of the tunneling probability and therefore a drastic decrease of alpha half-lives compared to the field-free case and the continuous wave case.
Outcomes of 44 Consecutive Complete Bilateral Cleft Lip and Palate Patients Treated with Secondary Alveolar Bone Grafting and Premaxillary Osteotomy
Authors: Scott Rupert , Scott Julia , Stagnell Sami , Robinson Steve , Flood Tim 
Published: March 2016

Objective To report the surgical outcomes of secondary alveolar bone grafting with premaxillary osteotomy in a single surgeon cohort of complete bilateral cleft lip and palate patients. Design Retrospective review of 44 consecutive patients using hospital notes and radiographs. Setting Single specialist cleft lip and palate center, UK. Patients Consecutive patients with complete bilateral cleft lip and palate who were being treated with secondary alveolar bone grafting incorporating premaxillary osteotomy. Outcome Measures Assessment of success of bone graft by Kindelan score; canine eruption; closure of fistulae and assessment of morbidity. Results Between January 6, 2000, and August 8, 2013, 44 patients with complete BCLP underwent secondary ABG with a premaxillary osteotomy as a one-stage procedure. The mean follow-up was 7.3 years (range 1.4 to 14.6). Eighty-five percent of ABGs were successful (a Kindelan score of 1 or 2), and canine eruption was 89%. Failure of the ABG occurred in 7%. Fistulae recurrence rate was 11%, all of which were asymptomatic. No premaxillae were devitalized. Conclusion Incorporating a premaxillary osteotomy into the secondary ABG surgical protocol can be a safe technique that gives excellent surgical exposure for fistula repair.
La internación involuntaria en la legislación Argentina y Brasilera desde la perspectiva de los Derechos Humanos
Authors: Puccio Sofia 
Published: March 2016

El artículo tiene como objetivo analizar comparativamente la legislación argentina y brasilera relativa a internación psiquiátrica involuntaria y protección de los derechos humanos de pacientes con sufrimiento mental. Es una investigación descriptivo-analítica, de base documental y legislativa con análisis cualitativo. Tanto en Brasil como en Argentina existen leyes sobre la materia, en la legislación argentina, la Ley n° 26.657, del 2010, que dispone sobre los derechos de protección a la salud mental de todas las personas y el Decreto Reglamentario n° 603 del 2013: en la legislación brasilera, la Ley 10.216 del 2001,que dispone sobre los derechos de las personas portadoras de trastornos mentales y la Portería GM n° 2391 del 2002 que reglamenta el control de las internaciones psiquiátricas involuntarias (IPI) y voluntarias (IPV) y los procedimientos de notificación de la comunicación de las IPI y IPV al Ministerio Público por establecimientos de salud, integrantes y no de SUS. Se establecen los conceptos fundamentales para la comprensión del tema, luego se analizan las influencias de la Convención de Caracas en la legislación de ambos países, para luego presentar el proceso de reforma psiquiátrica. Por fin, con base en un estudio de derecho comparado, se analiza la legislación de los dos países. A pesar de haber crecido Argentina y Brasil en la consolidación de su legislación en salud mental en los últimos años, el poco tiempo que tienen desde su implementación, evidencia que falta avanzar en el control y procedimiento de las internaciones para asegurar que las políticas públicas protejan los Derechos Humanos.
Além do principio da imaginação
Authors: Ramos Maria Luiza 
Published: March 2016

Resumo: Apresentando reflexões sobre a metonímia e a métafora, tanto do ponto de vista retórico quanto psicanalítico, este ensaio analisa um texto poético, em suas relações com atos de linguagem típicos do inconsciente.Résumé: Dans cet essai on fait des réflexions sur la métonymie et la métaphore, aussi bien du point de vue rhétorique que psychanalytique. Au cours de l'argumentation on a fait usage d'un texte poétique, dans ses rapports avec des actes de langage typiques de l'inconscient.
STUDI HISTOKIMIA LEKTIN TERHADAP JENIS DAN DISTRIBUSI GLIKOKONJUGAT ABOMASUM KERBAU RAWA (Bubalus bubalis) KALIMANTAN SELATAN
Authors: Nurliani Anni , Budi Pitojo Teguh , Kusindarta Dwi Liliek 
Published: March 2016

Penelitian ini bertujuan mengkaji efisiensi pencernaan kerbau rawa dengan mengidentifikasi jenis dan distribusi glikokonjugat pada daerah abomasum kerbau rawa. Enam ekor kerbau rawa jantan 2,5 tahun dan berat badan 300-400 kg digunakan dalam penelitian ini. Sampel diperoleh dari rumah potong hewan (RPH) Kabupaten Banjar, Kalimantan Selatan. Setiap bagian abomasum meliputi kardiak, fundus, dan pilorus diambil untuk pengamatan mikroskopis dengan pewarnaan hematoksilin-eosin (HE) dan alcian blue-periodic acid schiff (AB-PAS). Residu gula glikokonjugat pada abomasum dideteksi dengan pewarnaan histokimia lektin dengan menggunakan wheat germ agglutinin (WGA), ricinus communis agglutinin (RCA), concanavalin agglutinin (Con A), ulex europaeus agglutinin (UEA), dan soybean agglutinin (SBA). Hasil penelitian menunjukkan bahwa daerah kardiak mengandung glikokonjugat D manosa/D glukosa, D galaktosa, dan N asetilglukosamin. Daerah fundus mengandung D manosa/D glukosa, D galaktosa, L fukosa, N asetilglukosamin, dan N asetilgalaktosamin. Daerah pilorus mengandung glikokonjugat L fukosa dan N asetilglukosamin. Pola reaktivitas daerah kardiak, fundus, dan pilorus kerbau rawa terhadap pewarnaan histokimia lektin memiliki pola yang berbeda dengan ruminansia lain. Jenis glikokonjugat yang dimiliki oleh kerbau rawa tersebut diduga berkaitan dengan fungsi peningkatan kemampuan efisiensi pencernaan kerbau rawa. Setiap bagian abomasum kerbau rawa memiliki jenis glikokonjugat yang spesifik dengan pola distribusi khas sesuai dengan fungsinya.
DEFORMASI SENDI TARSUS PADA PREPARAT KAKI BELAKANG KUDA DELMAN
Authors: Sukareksi Hazar , N Nurhidayat 
Published: March 2016

Penelitian ini bertujuan mempelajari deformasi sendi tarsus yang mengalami tarsitis kronis. Penelitian ini dilakukan dengan mengamati perubahan ukuran sendi tarsus pada preparat kaki belakang kuda delman dan deformasi skelet sendi tarsus pada kuda delman. Dari hasil penelitian ditemukan adanya pembesaran di bagian medial tarsus kuda dan pembesaran pada lingkar tarsus kuda 3-7 cm dari bentuk normal dengan rata-rata lingkar tarsus kuda delman 23,18 cm dan rata-rata lingkar tarsus pada kuda yang mengalami tarsitis 27,83 cm. Kelainan berupa perlekatan tulang (ankylosis) dan pertumbuhan tulang baru (exostosis) pada permukaan tulang-tulang sendi tarsus kuda. Pada gambaran radiografiditemukan adanya penyempitan ruang sendi, kerusakan permukaan tulang dan pertumbuhan tulang baru yang abnormal. Deformasi yang terjadipada sendi tarsus preparat kaki belakang kuda delman diduga disebabkan oleh aktivitas yang berat semasa hidupnya.
PEMBERIAN EKSTRAK EPIDIDIMIS BERPOTENSI MENINGKATKAN KUALITAS SPERMATOZOA KAMBING JANTAN LOKAL
Authors: Akmal Muslim , Siregar Tongku Nizwan , Wahyuni Sri , Hambal Muhammad , S Sugito , A Amiruddin , S Syafruddin , R Roslizawaty , Z Zainuddin , Adam Mulyadi , G Gholib , Iskandar Cut Dahlia , R Rinidar , Asmilia Nuzul , H Hamny , J Joharsyah , S Suriadi 
Published: March 2016

Penelitian ini bertujuan mengetahui pengaruh pemberian ekstrak epididimis (EE) terhadap peningkatan kualitas spermatozoa kambing jantan lokal. Dalam penelitian ini digunakan 12 ekor kambing jantan lokal, berumur 1,5 tahun dengan bobot badan 10-15 kg dan dibagi atas empat kelompok (K0, KP1, KP2, dan KP3). Kelompok K0, hanya diinjeksi dengan NaCl fisiologis sedangkan kelompok KP1, KP2, dan KP3 diinjeksi EE masing-masing 1, 2, dan 3 ml/ekor selama 13 hari berturut-turut. Pada hari ke-14, dilakukan pengambilan semen kambing dengan elektroejakulator dan selanjutnya dilakukan pemeriksaan kualitas spermatozoa. Hasil penelitian menunjukkan bahwa pemberian EE dengan dosis 1 dan 3 ml/ekor EE selama 13 hari berturut-turut menyebabkan peningkatan kualitas spermatozoa dibanding kelompok kontrol. Berdasarkan hal tersebut dapat disimpulkan bahwa EE berpotensi meningkatkan kualitas spermatozoa pada kambing jantan lokal.
Technology Focus: Deepwater Projects (May 2015)
Authors: Iversen Morten 
Published: March 2016

Technology Focus
As the oil and gas industry pushes into deeper water, more-complex environments, and frontier unproduced areas, the technical and nontechnical risks related to appraisal and development of deepwater projects are likely to continue to increase substantially.
While the technical challenges related to deepwater developments are significant— perhaps more significant and critical to the venture success—it is important that the nontechnical aspects of managing a new development in a frontier area be incorporated at the onset.
After the successful discoveries in deepwater basins across the globe in west Africa, the North Sea, the Gulf of Mexico, Brazil, and elsewhere, operators are using the lessons learned and technologies developed in these fields to explore other frontier deepwater fields.
The exploration in deep water becomes complex on the basis of various factors, such as water depth, geological formations, weather conditions, lack of oilfield infrastructure, and material and tools availability.
The definition of deep water may vary with operators, but one definition of a deepwater field is any area of exploration where the water depth is greater than 150 m and there is a subsea blowout preventer. NORSOK defines deep water as water depth in excess of 600 m. Deep water may range from 600 to 3000 m, and ultradeep water is anything deeper than that.
Deepwater operations create several additional challenges that need to be addressed in the design phase. Some of these, such as low temperatures at seabed, shallow flow hazards, and possible hydrates, are problems that are most commonly associated with deepwater operations. Other challenges, such as low fracture gradients and proper mud removal for cement placement and zonal isolation, are also common in nondeepwater environments; however, these become more complex, more significant, and more difficult to manage in deep water.
There is no question that deepwater production will play a very important part in meeting the world’s future energy demand. The challenge for the oil and gas industry is to meet this demand safely, efficiently, and profitably.
This is not an easy challenge in deep water, given the limited margin for error. The technical complexity and multibillion-dollar development costs require a robust development strategy that allows a project to deliver the promised value within the constraints of time. JPT
Recommended additional reading at OnePetro: www.onepetro.org.
OTC 25135 Deepwater Development Strategy by Martijn Dekker, Shell, et al.
OTC 25443 50 Reservoirs, 48 Well Slots, and Two TLPs—Maximizing Recovery From the Deepwater Prolific Mars Field by Derek Newberry, Shell
SPE 169245 Overcoming Ultradeepwater Cementing Challenges.in.the Caribbean by N. Gupta,_Schlumberger, et al.
SPE 170286 A Novel Approach in Locating Single Loss Zone During Deepwater Drilling With Distributed- Temperature Measurement by Yuanhang Chen, The University of Tulsa, et al.