bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Urolithiasis in Anorexia Nervosa: A Population‐Based Cohort Study Using the Health Improvement Network
Authors: Denburg Michelle R. , Leonard Mary B. , Jemielita Thomas O. , Golden Neville H. , Tasian Gregory , Copelovitch Lawrence 
Published: June 2017

AbstractThis population‐based retrospective cohort study sought to determine if anorexia nervosa (AN) is associated with a higher risk of urolithiasis. Nine thousand three hundred two females with AN were compared to 92 959 randomly selected age‐matched and practice‐matched females. Cox regression was used to estimate the hazard ratio (HR) for urolithiasis and evaluate effect modification by age. Twenty‐three participants with AN (0.25%) developed urolithiasis compared with 154 unexposed participants (0.17%) over a median of 4 years of observation. The risk of urolithiasis varied significantly with age (interaction p = 0.02). AN was associated with a more than threefold higher risk of urolithiasis in females ≤25 years of age (HR 3.49, 95% CI: 1.56–7.81; p = 0.002), but not in females over 25 years (HR 1.18, 95% CI: 0.69–2.02; p = 0.54). The distribution of diagnosis codes for urolithiasis differed between groups (p = 0.04), with a higher proportion of codes for uric acid urolithiasis in the AN (16.2%) versus unexposed group (5.0%). Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
Development and Validation of a Decision Tool for Early Identification of Adult Patients with Severe and Complex Eating Disorder Psychopathology in Need of Highly Specialized Care
Authors: Dingemans Alexandra E. , Goorden Maartje , Lötters Freek J.B. , Bouwmans Clazien , Danner Unna N. , van Elburg Annemarie A. , van Furth Eric F. , Hakkaart‐van Roijen Leona 
Published: June 2017

SummaryPatients with complex and severe eating disorders often receive a number of ineffective or/and insufficient treatments. Direct referral of these patients to highly specialized tertiary treatment facilities in an earlier stage of the disorder is likely to be more (cost)‐effective. The aim of the study was to develop a decision tool that aids clinicians in early identification of these patients. After identification of criteria that were indicative of severity and complexity of eating disorder psychopathology by means of a systematic review of literature and consultation of a focus group, a Delphi method was applied to obtain consensus from experts on the list of relevant criteria. Finally, the decision tool was validated in clinical practice, and cut‐off criteria were established. The tool demonstrated good feasibility and validity to identify patients for highly specialized tertiary care. The final decision tool consisted of five criteria that can easily be implemented in clinical practice. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
Pay less, consume more? The price elasticity of home care for the disabled elderly in France
Authors: Roquebert Quitterie , Tenand Marianne 
Published: June 2017

AbstractLittle is known about the price sensitivity of demand for home care of the disabled elderly. We partially fill this knowledge gap by using administrative data on the beneficiaries of the main French home care subsidy program in a department and exploiting interindividual variation in provider prices. We address the potential endogeneity of prices by taking advantage of the unequal spatial coverage of providers and instrumenting price by the number of municipalities served by a provider. We estimate a price elasticity of around −0.4 that is significantly different from both 0 and −1. This less than proportionate response of consumption to price has implications for the efficiency and redistributive impact of variation in the level of copayments in home care subsidy schemes.
Cytomegalovirus infection in hematologic malignancy settings other than the allogeneic transplant
Authors: Marchesi F. , Pimpinelli F. , Ensoli F. , Mengarelli A. 
Published: June 2017

AbstractCytomegalovirus (CMV) infection in clinical settings other than the allogeneic transplant represents a poorly explored issue. Thus, we performed a comprehensive review of the medical literature about CMV infection in patients undergoing autologous hematopoietic stem cell transplant and in other nontransplant‐related hematologic patients. In autologous hematopoietic stem cell transplant, a CMV reactivation is reported to occur in up to 41% of CMV seropositive patients, when a prospective monitoring of antigenemia and/or viremia by polymerase chain reaction was adopted. However, more contained frequencies, up to 12%, have been reported when the monitoring criteria were based on a clinically driven diagnostic strategy. The most relevant risk factors appear to be CD34 + selected autografts, total body irradiation, and prior treatment with Alemtuzumab, Fludarabine, or Bortezomib, respectively. Other possible risk factors (ie, prior treatment with Rituximab, T‐cell lymphomas, and pretransplant HBcIgG seropositivity) are still debated. In nontransplant settings, the data are very heterogeneous; thus, CMV infection incidence and risk factors are more difficult to establish. Overall, the rate of CMV infection/reactivation ranges between 2 and 67%. High‐dose steroids, advanced disease, poor performance status, and treatment with Alemtuzumab, Fludarabine, Bortezomib, and Rituximab appear as the most relevant, though putative, risk factors. Intravenous Ganciclovir represents the gold standard for first‐line treatment of CMV infection in these patients. Oral Valganciclovir and Foscarnet are other possible options. Extensive prophylaxis and preemptive therapy are not generally recommended, with the exception of high‐risk patients.
Sodium salicylate modulates inflammatory responses through AMP‐activated protein kinase activation in LPS‐stimulated THP‐1 cells
Authors: Bao Weiwei , Luo Yaru , Wang Dan , Li Jian , Wu Xi , Mei Wei 
Published: June 2017

AbstractSodium salicylate (NaSal) is a nonsteroidal anti‐inflammatory drug. The putative mechanisms for NaSal's pharmacologic actions include the inhibition of cyclooxygenases, platelet‐derived thromboxane A2, and NF‐κB signaling. Recent studies demonstrated that salicylate could activate AMP‐activated protein kinase (AMPK), an energy sensor that maintains the balance between ATP production and consumption. The anti‐inflammatory action of AMPK has been reported to be mediated by promoting mitochondrial biogenesis and fatty acid oxidation. However, the exact signals responsible for salicylate‐mediated inflammation through AMPK are not well‐understood. In the current study, we examined the potential effects of NaSal on inflammation‐like responses of THP‐1 monocytes to lipopolysaccharide (LPS) challenge. THP‐1 cells were stimulated with or without 10 ug/mL LPS for 24 h in the presence or absence of 5 mM NaSal. Apoptosis was measured by flow cytometry using Annexin V/PI staining and by Western blotting for the Bcl‐2 anti‐apoptotic protein. Cell proliferation was detected by EdU incorporation and by Western blot analysis for proliferating cell nuclear antigen (PCNA). Secretion of pro‐inflammatory cytokines (TNF‐α, IL‐1β, IL‐6) was determined by enzyme‐linked immunosorbent assay (ELISA). We observed that the activation of AMPK by NaSal was accompanied by induction of apoptosis, inhibition of cell proliferation, and increasing secretion of TNF‐α and IL‐1β. These effects were reversed by Compound C, an inhibitor of AMPK. In addition, NaSal/AMPK activation inhibited LPS‐induced STAT3 phosphorylation, which was reversed by Compound C treatment. We conclude that AMPK activation is important for NaSal‐mediated inflammation by inducing apoptosis, reducing cell proliferation, inhibiting STAT3 activity, and producing TNF‐α and IL‐1β.
On the structure of (pan, even hole)‐free graphs
Authors: Cameron Kathie , Chaplick Steven , Hoàng Chính T. 
Published: June 2017

AbstractA hole is a chordless cycle with at least four vertices. A pan is a graph that consists of a hole and a single vertex with precisely one neighbor on the hole. An even hole is a hole with an even number of vertices. We prove that a (pan, even hole)‐free graph can be decomposed by clique cutsets into essentially unit circular‐arc graphs. This structure theorem is the basis of our ‐time certifying algorithm for recognizing (pan, even hole)‐free graphs and for our ‐time algorithm to optimally color them. Using this structure theorem, we show that the tree‐width of a (pan, even hole)‐free graph is at most 1.5 times the clique number minus 1, and thus the chromatic number is at most 1.5 time the clique number.
Color degree and monochromatic degree conditions for short properly colored cycles in edge‐colored graphs
Authors: Fujita Shinya , Li Ruonan , Zhang Shenggui 
Published: June 2017

AbstractFor an edge‐colored graph, its minimum color degree is defined as the minimum number of colors appearing on the edges incident to a vertex and its maximum monochromatic degree is defined as the maximum number of edges incident to a vertex with a same color. A cycle is called properly colored if every two of its adjacent edges have distinct colors. In this article, we first give a minimum color degree condition for the existence of properly colored cycles, then obtain the minimum color degree condition for an edge‐colored complete graph to contain properly colored triangles. Afterwards, we characterize the structure of an edge‐colored complete bipartite graph without containing properly colored cycles of length 4 and give the minimum color degree and maximum monochromatic degree conditions for an edge‐colored complete bipartite graph to contain properly colored cycles of length 4, and those passing through a given vertex or edge, respectively.
Safety and efficacy of venous reconstruction in liver resection using cryopreserved homologous veins
Authors: Yamamoto Masaki , Akamatsu Nobuhisa , Hayashi Akimasa , Togashi Junichi , Sakamoto Yoshihiro , Tamura Sumihito , Hasegawa Kiyoshi , Fukayama Masashi , Makuuchi Masatoshi , Kokudo Norihiro 
Published: June 2017

AbstractBackgroundOnly a few studies have reported the resection and reconstruction of major hepatic veins during hepatectomy. Here, we present our strategy and techniques for venous reconstruction with cryopreserved homologous veins, and describe the surgical outcome.MethodsAmong 2,387 hepatectomy patients, 39 patients who required hepatic venous reconstruction were reviewed retrospectively. Venous reconstruction was performed to secure a non‐congested liver remnant volume of at least 40% of the total liver volume.ResultsThere was no operative mortality, and the severe morbidity rate was 5% in this series. A total of 41 veins were reconstructed; 30 with homologous veins (73.2%) and 11 with autologous veins (26.8%), with the middle hepatic vein being the most frequent (n = 23, 56%). Interposition grafting was performed more often (P = 0.003), the length of the venous resection was longer (P = 0.007), and pathologic wall infiltration of the vein was revealed more often (P = 0.002) in the homologous graft group than in the autologous graft group. The 1‐, 2‐, and 3‐year overall patency of the reconstructed veins was 55.4%, 46.3%, and 46.3%, respectively.ConclusionsAggressive venous reconstruction during hepatectomy using cryopreserved homologous veins is a feasible option with satisfactory short‐term outcomes, and may be warranted to improve operative safety.
Differentiation of olfactory neuroblastomas from nasal squamous cell carcinomas using MR diffusion kurtosis imaging and dynamic contrast‐enhanced MRI
Authors: Xiao Zebin , Tang Zuohua , Qiang Jinwei , Qian Wen , Zhong Yufeng , Wang Rong , Wang Jie , Wu Lingjie , Tang Wenlin 
Published: June 2017

PurposeTo evaluate the use of magnetic resonance (MR) diffusion kurtosis imaging (DKI) and dynamic contrast‐enhanced MR imaging (DCE‐MRI) in the differentiation of olfactory neuroblastomas (ONBs) from squamous cell carcinomas (SCCs).Materials and MethodsDKI and DCE‐MRI were performed in 17 patients with ONBs and 23 patients with SCCs on a 3T MR scanner. Parameters derived from DKI and DCE‐MRI were measured and compared between ONBs and SCCs using an independent samplest‐test. The sensitivity, specificity, accuracy, positive predictive values (PPV), negative predictive values (NPV), and the area under the receiver operating characteristic (ROC) curve were determined.ResultsThe mean kurtosis (K) value of ONBs was significantly higher than that of SCCs (P< 0.001), and the mean fractional volume in the extravascular extracellular space (Ve) value of ONBs was lower than that of SCCs (P< 0.001). The ROC curve analyses yielded a cutoff K value of 0.953, with a sensitivity of 94.1%, a specificity of 69.6%, and an accuracy of 80.0%; the cutoff Vevalue was 0.493, with a sensitivity of 70.6%, a specificity of 95.7%, and an accuracy of 85.0%. A parallel test with K value >0.953 or Vevalue ≤0.493 achieved a sensitivity of 94.1%, a specificity of 100.0%, and an accuracy of 97.5% for differentiating ONBs from SCCs.ConclusionThe K value of DKI and Vevalue of DCE‐MRI have potential use in the differentiation of ONBs and SCCs.Level of Evidence:3Technical Efficacy:Stage 2J. Magn. Reson. Imaging 2018;47:354–361.
A comprehensive analytical study of electrical properties of carbon nanotube field‐effect transistor for future nanotechnology
Authors: Singh Ajay Kumar , Naresh Kumar B. , Ramana Murthy G. , Prabu C.M.R. 
Published: June 2017

AbstractThis paper discusses a comprehensive analytical study of electrical properties of single‐wall conventional carbon nanotube field‐effect transistor (CNTFET) devices of subthreshold swing (SS), transconductance (gm), and extension resistance. The analytical expressions for SS and gm have been derived based on channel modulated potential. In the study, it was observed that SS value of the CNTFET device is equal to 60 mV/decade, which is smaller than the conventional and double gate metal‐oxide‐semiconductor field‐effect transistors. The subthreshold swing degrades at larger tube's diameter and gate‐source voltage due to increased source‐drain leakage current. Carbon nanotube field‐effect transistor devices achieve larger gm at large gate‐source voltage, which has a disadvantage of reducing the allowable voltage swing at the drain. The extension resistance of the device falls with diameter of the tube.
Stratigraphy, age and correlation of two widespread Late Holocene tephras preserved within Lake Kutubu, Southern Highlands Province, Papua New Guinea
Authors: Schneider Larissa , Alloway Brent V. , Blong Russell J. , Hope Geoff S. , Fallon Stewart J. , Pain Colin F. , Maher William A. , Haberle Simon G. 
Published: June 2017

ABSTRACTSediment cores were retrieved from Lake Kutubu, the largest upland lake in Papua New Guinea, to assess palaeoenvironmental baselines. Two prominent tephra layers were encountered within the cores. Using a combination of core stratigraphy, sediment properties and geochemical characterization (electron microprobe and laser ablation inductively coupled‐plasma mass spectrometry techniques) we were able to correlate these tephras with Tibito and Olgaboli tephras, both previously described at adjacent distal localities. Glass shard compositional data of Tibito tephra from Lake Kutubu, Kuk swamp and from proximal volcaniclastic successions from Long Island are indistinguishable and this similarity strongly supports Long Island as the eruptive source. For Olgaboli tephra, the location of its eruptive source is less certain but the glass shard compositional data indicate a Karkar Island source. The occurrence of Tibito and Olgaboli tephras in Lake Kubutu sediments extends their known distributions further south‐west into the southern Highlands region and affirms their importance as inter‐regional stratigraphic markers, of late Holocene age, that have considerable potential for use in future palaeoenvironmental, archaeological and volcanic hazard and/or impact studies. Copyright © 2017 John Wiley & Sons, Ltd.
Patient‐reported outcome measures in advanced musculoskeletal physiotherapy practice: a systematic review
Authors: Fennelly Orna , Blake Catherine , Desmeules François , Stokes Diarmuid , Cunningham Caitriona 
Published: June 2017

AbstractObjectiveAdvanced practice physiotherapists (APPs), also known as extended scope physiotherapists, provide a new model of service delivery for musculoskeletal (MSK) disorders. Research to date has largely focused on health service efficiencies, with less emphasis on patient outcomes. The present systematic review aimed to identify the patient‐reported outcome measures (PROMs) being utilized by APPs.MethodA wide search strategy was employed, including the PubMed, Embase, CINAHL, CENTRAL and PEDro databases, to identify studies relating to PROMs utilized by APPs in MSK healthcare settings. PROMs identified were classified into predetermined outcome domains, with additional contextual data extracted.ResultsOf the initial 12,302 studies, 38 met the inclusion criteria. These involved APPs across different settings, utilizing 72 different PROMs and most commonly capturing: Patient Satisfaction, Quality of Life (QoL), Functional Status, and Pain; and, less frequently: Global Status (i.e. overall improvement), Psychological Well‐Being, Work ability, and Healthcare Consumption and Costs. The quality of the PROMs varied greatly, with Satisfaction most commonly measured utilizing non‐standardized locally‐devised tools; the EuroQol five‐dimensions questionnaire (EuroQoL‐5D) and 36‐Item Short‐Form (SF‐36) cited most frequently to capture QoL; and the Visual Analogue Scale (VAS) to capture Pain. No key measure was identified to capture Functional Status, with 15 different tools utilized.ConclusionAPPs utilized a multiplicity of PROMs across a range of MSK disorders. The present review will act as an important resource, informing the selection of outcomes for MSK disorders, with a view to greater standardization of outcome measurement in MSK clinical practice, service evaluation and research.
Cooperative receding horizon strategies for the multivehicle routing problem
Authors: Pietrabissa Antonio , Di Giorgio Alessandro , Oddi Guido , Chini Giorgia , Chiang Ming‐Li , Poli Cecilia 
Published: June 2017

SummaryThis paper deals with the dynamic Euclidean Multivehicle Routing Problem (MVRP) in both deterministic and uncertain scenarios. The objective of MVRP is to find the best paths for a fleet of vehicles that are cooperative to visit a set of targets. Based on the cooperative receding horizon (CRH) approach proposed in some previous works, which is vehicle‐oriented, in this paper, we consider a target‐oriented CRH, named tCRH, and then we propose a switching scheme, named sCRH, which is able to dynamically adjust the vehicle behaviors according to the time‐varying configuration of both vehicles and targets, as well as to handle the situation with the appearance of unknown targets. The proposed sCRH counteracts the oscillation problem of CRH and improves the overall routing performances by adopting the advantages of both CRH and tCRH approach. Convergence results and simulation results are provided to validate the proposed approach.
Mixed micellization study of ibuprofen (sodium salt) and cationic surfactant (conventional as well as gemini)
Authors: Kumar Dileep , Rub Malik Abdul , Azum Naved , Asiri Abdullah M. 
Published: June 2017

AbstractHerein, we have studied the interaction between cationic surfactant (conventional [myristyltrimethylammonium bromide, MTAB] as well as gemini surfactant 1, 4‐butanediyl‐α, ω‐bis(dimethyltetradecylammonium bromide) (14‐4‐14)) and anti‐inflammatory sodium salt of ibuprofen (IBU) drug in aqueous solutions by using tensiometry method at 298.15 K. The means of the interaction of drugs by added foreign materials is of paramount importance in the drug delivery. Ibuprofen is used for the relief of pain, fever, and swelling. From this study we have evaluated different parameters, for example, critical micelle concentration (cmc), micellar mole fraction of mixed micelles/mixed interface (X1m/X1σ), micellar/surface interaction parameter (βm/βσ), activity coefficients (f1m/f1σ and f2m/f2σ) of the mixed micelles/mixed interface, excess Gibbs free energy of mixed monolayer/mixed micelle formation (
/
), surface excess concentration (Γmax) etc. and discussed in detail. The micellar interaction parameter (βm) was determined from the critical micelle concentration values of the pure surfactant (MTAB/14‐4‐14) and IBU (cmc1 and cmc2) and the mixed system (cmc) using the Rubingh's model. In addition to this, various other parameters such as packing parameters of amphiphiles in the micelles (P), volume contribution of the hydrophobic chain (V0), and its effective length (lc), have also been calculated. The value of micellar mole fraction (
) is found to be more for IBU + 14‐4‐14 mixtures as compared to IBU + MTAB mixtures at lower mole fraction and vice versa at a higher mole fraction of surfactant. The ΔGom and ΔGoads values for all studied systems were found out to be negative, ie, micellization, as well as adsorption processes, are found to be energetically favorable.
Exploring the utility of coumarins‐based luminescent spectra converters
Authors: Lapina Viktoryia A. , Pavich Tatiyana A. , Pershukevich Piotr P. , Trofimov Aleksei V. , Trofimova Natalia N. , Tsaplev Yurii B. , Zak Pavel P. 
Published: June 2017

AbstractThe physicochemical aspects of functioning the luminescent converters for a rational modification of the emission spectra of light‐emitting diodes are considered. These converters use laser dyes' coumarins 314, 334, and 343 to transfigure the primary light‐emitting diode spectrum. The fine control of the emission spectra of the mentioned coumarins in polymeric matrices was achieved by introducing nonionic detergents. The relevant characteristics of the photochemical persistence of coumarins in the polymer layers are acquired.
An assessment of ground‐based GNSS Zenith Total Delay observation errors and their correlations using the Met Office UKV model
Authors: Bennitt G. V. , Johnson H. R. , Weston P. P. , Jones J. , Pottiaux E. 
Published: June 2017

Ground‐based GNSS Zenith Total Delay (ZTD) observations have been assimilated into the Met Office numerical weather prediction (NWP) models since 2007, and into the Met Office UKV model since its introduction in 2009. The UKV model is a 1.5 km resolution convective‐scale model and uses a 3D‐Var assimilation system. There is a plan to upgrade the UKV assimilation system from 3D‐Var to 4D‐Var in the near future, giving the opportunity to increase the temporal resolution of ZTDs assimilated. The ZTD observation‐error covariances used operationally are assumed to be uncorrelated in both space and time despite the expectation that ZTDs have temporally and spatially correlated observation errors due to the production method (e.g. batch processing using a sliding window and (time) relative constraints). To assess whether these error correlations should be accounted for in order to use ZTDs at higher temporal resolution, a posteriori diagnostics to estimate the extent of temporal and spatial error correlations in ZTD observations over the UK, BENELUX and Northern France are used.Over two separate month‐long periods, we find that ZTD observations within the same processing batch are correlated, and that correlations persist between different batches to at least 1 h. Spatially, ZTD observations are found to be correlated to a minimum of 62.5 km. We find that the extent of the diagnosed correlation between observations separated in space and time is affected by the value of the relative constraints parameter chosen by the processing centre in the GNSS processing software. The impact of the relative constraints parameter on the diagnosed error variances is greater than that revealed by innovation statistics alone.