bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aberrant telomere length and mitochondrial DNA copy number in suicide completers
Authors: Otsuka Ikuo , Izumi Takeshi , Boku Shuken , Kimura Atsushi , Zhang Yuan , Mouri Kentaro , Okazaki Satoshi , Shiroiwa Kyoichi , Takahashi Motonori , Ueno Yasuhiro , Shirakawa Osamu , Sora Ichiro , Hishimoto Akitoyo 
Published: June 2017

AbstractShort telomere length (TL) occurs in individuals under psychological stress, and with various psychiatric diseases. Recent studies have also reported mitochondrial DNA copy number (mtDNAcn) alterations under several neuropsychiatric conditions. However, no study has examined whether aberrant TL or mtDNAcn occur in completed suicide, one of the most serious outcomes of mental illnesses. TL and mtDNAcn in post-mortem samples from 528 suicide completers without severe physical illness (508 peripheral bloods; 20 brains) and 560 samples from control subjects (peripheral bloods from 535 healthy individuals; 25 post-mortem brains) were analysed by quantitative polymerase chain reaction. Suicide completers had significantly shorter TL and higher mtDNAcn of peripheral bloods with sex/age-dependent differences (shorter TL was more remarkably in female/young suicides; higher mtDNAcn more so in male/elderly suicides). The normal age-related decline of TL and mtDNAcn were significantly altered in suicide completers. Furthermore, shorter TL and lower mtDNAcn of post-mortem prefrontal cortex were seen in suicide completers compared to controls. This study shows the first association of aberrant telomeres and mtDNA content with suicide completion. Our results indicate that further research on telomere shortening and mitochondrial dysfunction may help elucidate the molecular underpinnings of suicide-related pathophysiology.
A possible pathogenetic factor of sickle-cell disease based on fluorescent analysis via an optofluidic resonator
Authors: Dai Hailang , Yin Cheng , Ye Xiaona , Jiang Bei , Ran Maowu , Cao Zhuangqi , Chen Xianfeng 
Published: June 2017

AbstractWaveguide based optofluidic resonator features high precision and high sensitivity in real-time fluorescent analysis. We present a novel optofluidic resonator following the hollow-core metal-cladding waveguide structure, which is then used to record the real-time binding process of Fe2+ and Fe3+ with protoporphyrin IX (PpIX) in PBS solution, respectively. The central fluorescent wavelength of compound with Fe2+ is in good accordance with that of the normal hemoglobin, whilst the peaks of the Fe3+ compound match the hemoglobin specimen from sickle-cell disease (SCD) patients. Similar statement holds when we monitor the real-time oxidation processes of these products by injecting oxygen into the optofluidic chip. These observations lead to the speculation that the SCD is caused by replacing the Fe2+ in hemoglobin with Fe3+, which may be insightful in the discovery of new clinical routes to cure this disease.
Goal-Directed Drinking Behaviors Can Be Modified Through Behavioral Mimicry
Authors: Shune Samantha E. , Foster Kayla A. 
Published: June 2017

Purpose
This study tested whether behavioral mimicry can alter drinking behavior. It was hypothesized that participants would increase drinking behaviors given increased confederate drinking but not cup touching.

Methods

Nineteen healthy adults (
M
age
= 20.32 years) completed 2 picture description tasks; during 1 task, a confederate frequently sipped water (
complete
drinking gesture), and during the other, the confederate touched her cup but did not drink (
partial
gesture). Outcome measures included number of drinks per minute, number of cup touches per minute, percentage of time spent drinking, and percentage of time spent touching the cup.

Results
Participants spent more time drinking and had an increased drinking rate during the drinking condition versus the cup-touching condition. For a majority of participants, drinking rate increased during the drinking condition versus baseline. Drinking, but not cup touching, rate also increased given increased confederate cup touching for many.

Conclusions
Mimicry likely contributes to social modeling of drinking behaviors. This effect appears more robust given a complete target gesture (full drink); however, a partial goal-directed drinking gesture may also yield a mimicked response. Beyond the theoretical implications, these results provide directions for research investigating more naturalistic mechanisms for increasing dietary intake in various patient populations (e.g., individuals with dysphagia).
Multimodality Management of Cavernous Sinus Hemangiomas—An Institutional Experience
Authors: Sarma Pragyan , Shukla Dhaval , Bhat Dhananjay , Pandey Paritosh , Somanna Sampath , Chandramouli Ananthakrishna , Srinivas Dwarakanath 
Published: June 2017

Objective Cavernous sinus hemangiomas (CSHs) are benign lesions accounting for less than 2% of the cavernous sinus tumors. They provide a formidable surgical challenge because of their vascularity and their being surrounded by critical neurovascular structures. In this study, one of the largest in available literature, we analyze our experience in the management of these unusual tumors and review the available literature.
Materials This is a retrospective analysis of patients who were managed surgically (both microsurgical and Gamma knife radiosurgery [GKRS]) for CSH at our Institution from 2007 to 2015. Complete demographic, clinical-radiologic surgical records were analyzed. Follow-up data were collected from the hospital records.
Results Total 23 patients were managed. Among these, 15 patients underwent microsurgery (group 1) whereas 8 underwent GKRS (group 2). Predominant clinical presentation in both the groups included headache and involvement of multiple cranial nerves. Five patients in group 1 had deteriorating vision. The volume of tumors ranged from 29 to 115 cm3 (mean = 64.57 cm3) in group 1 and from 2.1 to 11.6 cm3 in group 2. GKRS was performed with a mean dose of 13 Gy, an average isodose line of 50% with an average coverage of 96%. In group 1, the follow-up period ranged from 6 to 62 months (mean = 29.4 months). The extraocular movement (EOM) preservation rate in our series was not favorable, as most patients presented late with large tumors and established deficits. Recurrence/residual tumor was seen in two cases. In group 2, the follow-up was 5 to 48 months. All of them showed significant reduction in size.
Conclusion Both surgery and radiosurgery are highly effective in the management of CSHs. They are complementary to each other, with individual characteristics—the size and volume of the lesion—being the main factors in deciding the choice of treatment.
Tibial Onlay Posterior Cruciate Ligament Reconstruction: Surgical Technique and Results
Authors: Nascimento Felipe , Ferreira Aline , Oliveira Luciano , Fogagnolo Fabricio , Kfuri Mauricio , Salim Rodrigo 
Published: June 2017

AbstractThe posterior cruciate ligament (PCL) is a fundamental structure in knee kinematics. PCL tears may lead to adverse consequences, such as impaired functional performance and an increased risk of osteoarthritis. Although surgical treatment is a well-established option for the patients of PCL rupture, many surgeons opt for conservative treatment because of the lack of consensus in the orthopedic literature concerning the best surgical method with less risk of iatrogenic lesions to the neurovascular structures in the popliteal region. Here, we describe an onlay technique for PCL reconstruction, which has some advantages over the traditional transtibial and over inlay techniques. The technique described in this study avoids the “killer angle”—frequently considered the cause of laxity of the reconstructed ligament—while simultaneously permitting safe retraction of the neurovascular structures without the need for a change in the patient's position. This technique has been used at our institution for approximately 10 years with very satisfactory results. The aim of this study is to describe the technique and perform a retrospective evaluation of the results of a case series.
Epileptiform Activity in Electroencephalogram of Normal Children
Authors: Alshahawy Azza , El-Shehaby Walid , Darwish Amira 
Published: June 2017

Objectives This prospective cohort study assessed the prevalence of epileptiform discharges (EDs) in a cohort of healthy Egyptian children aged 1 to 18 years.
Methods Children with a history of unprovoked seizure disorders, family history of epilepsy, neurological or psychological disorder, or any other chronic illness were excluded. Digital electroencephalogram (EEG) was recorded under resting condition for a minimum of 20 minutes including activation methods.
Results The study included 1,382 healthy Egyptian children with no history of unprovoked seizures. Twenty-nine normal children had EDs, which represents 2.1% of total number of studied children. Centrotemporal spikes were detected in 19 children. The prevalence of EDs was significantly higher in children aged 6 to 12 years (3.59%) compared with children aged 13 to 18 years (1.2%) and children aged 1 to 5 years (0.45%).
Conclusions EDs can be observed in nonepileptic normal children. Centrotemporal spikes are the most common epileptiform pattern in EEG of normal children. None of normal children with EDs developed seizures or other neurological disorders during follow-up.
Sagittal Plane Corrections around the Knee
Authors: Dejour David , La Barbera Giuseppe , Pasqualotto Stefano , Valoroso Marco , Nover Luca , Reynolds Ryan , Saffarini Mo 
Published: June 2017

AbstractStability of the knee joint depends on soft tissues integrity and bony balance in the frontal and sagittal planes during gait. Although frontal plane imbalance is a well-known knee pathology, commonly treated by high tibial osteotomy, sagittal plane imbalance is less common, with fewer and more challenging surgical treatment options. The purpose of this review is to describe the biomechanical effects of sagittal knee imbalances and to outline the indications, techniques, and outcomes of sagittal knee osteotomies. The article details the reference axes and methods to measure posterior tibial slope (PTS), the principal indicator of sagittal imbalance, and its influence on anteroposterior tibial translations and rotational stability of the joint. The authors also outline the roles of the anterior and posterior cruciate ligaments in maintaining sagittal balance, with focus on the associations between PTS and ligament deficiencies, as well as posterolateral corner injuries. Different techniques and indications of tibial osteotomy in the sagittal plane, both above and below the anterior tibial tubercle, are compared in terms of technical difficulty, clinical benefits, and complication rates. The authors conclude on the importance of understanding sagittal knee imbalance, particularly in cases of ligament deficiencies, where the deformity can be the primary cause for lesions. Surgeons must identify the underlying deformities associated with sagittal imbalance, which can be recognized on weight-bearing X-rays and magnetic resonance imaging scans. Different techniques of sagittal osteotomies offer effective treatments for certain indications and should be considered in selected cases for unstable knees with ligament lesions.
Preemptive Analgesia in Thumb Basal Joint Arthroplasty: Immediate Postoperative Pain with Preincision versus Postincision Local Anesthesia
Authors: Ilyas Asif , Labrum Joseph 
Published: June 2017

Purpose Currently no guidelines exist for the timing of the injection of anesthetics in surgeries performed under general anesthesia to minimize postoperative pain. To better understand the role of timing of the injection of local anesthesia in hand surgery performed under general anesthesia, we evaluated the effect of pre- versus postincisional local analgesic injection on immediate postoperative pain experience. We hypothesize that the preincisional (preemptive) injection will result in decreased immediate postoperative pain experience and analgesic use when compared with postincisional injection.
Methods Consecutive cases of thumb basal joint arthroplasty performed over a 4-year period were retrospectively reviewed. During the first half of the study period, the surgical site was infiltrated with 0.5% bupivacaine at the completion of surgery following closure. During the second half of the study period, the surgical site was infiltrated with 0.5% bupivacaine prior to skin incision. Data collected included patient demographics, immediate postoperative recovery room (PACU) pain scores, and postoperative opioid consumption in morphine equivalents.
Results Two-tailed t-test identified no significant difference between the pre- and postincision cohorts relative to PACU entrance pain scores and time spent in the PACU. PACU exit pain scores were significantly lower in the preincision cohort. The mean PACU pain score was also significantly lower in the preincision cohort. PACU opioid consumption, converted into morphine equivalents, was found to be 211 mg in the preincision versus 299 mg in the postincision cohort.
Conclusion The preincisional (preemptive) injection of local anesthesia was found to result in lower pain scores during and upon exit of the PACU as compared with the postclosure group. In addition, the preincision cohort also trended toward lower opioid consumption while in the PACU. Consideration should be given to the routine use of preincision injection of local anesthesia to maximize pain relief in a multimodal pain strategy in hand surgical patients.
Level of Evidence Therapeutic level III.
Epidemiological Profile of Malignant Brain Neoplasms in the Northern Region of Brazil: data from the Cancer Hospital Registry of the Instituto Nacional de Câncer
Authors: Adriano Filho Carlos Eduardo , Pinto Lenon Machado , Jesus Joel Monteiro de 
Published: June 2017

Objective Tumors of the central nervous system (CNS) are considered rare, with an incidence of 3.4 cases per 100,000 individuals worldwide. Although uncommon, CNS tumors have been gaining epidemiological importance due to their increased incidence and mortality. In Brazil, there is a lack of population research regarding CNS cancer, especially in the Northern region. Thus, the authors aim to trace an epidemiological profile of malignant brain neoplasms in the Northern region from 2001 to 2013.
Methods Data were collected from the Cancer Hospital Registry of the Instituto Nacional de Câncer (RHC-INCA, in the Portuguese acronym) and stratified according to origin, gender, age, detailed primary location, and histological type. A total of 742 cases were analyzed. Most of the cases came from inland areas, with a male predominance.
Results The most affected age groups were between 0 and 9 years old and between 30 and 49 years old, with an accentuated decrease in incidence starting at the age of 70 years old. The frontal lobe was the most affected area, followed by the temporal and parietal lobes. Astrocytic tumors accounted for 64.3% of cases, followed by embryonal tumors (18.2%), and ependymal tumors (7.4%). Among the astrocytic tumors, astrocytoma, not otherwise specified (NOS), and glioblastoma, NOS corresponded to 82.2% of the cases. Among embryonal tumors, medulloblastoma accounted for 71.9% of the cases.
Conclusion More epidemiological studies in this area, especially in the Northern region, are required to identify risk factors and allow prevention and early diagnosis.
A Novel TSC2 Variant Associated with an Extremely Rare Magnetic Resonance Imaging Finding of Focal Megalencephaly
Authors: Jallol Tarek , Chaudhary Mohammed , Muhaish Husam , Mashhour Miral , Baradie Raidah , Mir Ali 
Published: June 2017

AbstractTuberous sclerosis complex (TSC) is a neurocutaneous syndrome with an autosomal dominant pattern of inheritance. It is a multisystem genetic disease caused by mutations in the TSC1 and TSC2 genes. The neuroradiographic findings of TSC include cortical dysplasia (cortical tubers and cerebral white matter radial migration lines), subependymal nodules, and subependymal giant cell astrocytoma. In this article, we describe an interesting case of TSC with an extremely rare radiographic finding of focal right megalencephaly. Molecular genetic testing detected a heterozygous c.3814+2T>G (p.?) variant, not previously described in the literature. As per the 2012 International Tuberous Sclerosis Complex Consensus Group guidelines and the findings of the genetic testing, this mutation most probably should be considered as a pathogenic variant. There are few cases of hemimegalencephaly (HME) reported in the literature, associated with TSC. To our knowledge focal megalencephaly is an extremely rare neuroradiographic finding in patients with TSC and has been previously reported only once by Griffiths et al based on clinical diagnostic criteria. Despite the uncommon association, TSC is the only neurocutaneous syndrome with similar histological appearance to HME. It is recognized that the pathological features in TSC and HME are due to abnormal cell proliferation, migration, and organization which could also be a possible mechanism for the development of focal megalencephaly. The uncommon association of HME and TSC with cytological similarities makes us wonder if there could be similarities in the pathogenesis of these two conditions. The advances in molecular genetic testing, increasing use of next-generation sequencing, and discovery of new pathogenic variants could answer some of these questions.
Carbohydrate mouth rinse improves morning high‐intensity exercise performance
Authors: Clarke Neil D. , Hammond Scott , Kornilios Evangelos , Mundy Peter D. 
Published: June 2017

AbstractOral carbohydrate (CHO) rinsing has been demonstrated to provide beneficial effects on exercise performance of durations of up to one hour. The aim of the present study was to investigate the effects of CHO mouth rinsing on morning high‐intensity exercise performance. Following institutional ethical approval and familiarisation, 12 healthy males (mean ± SD age: 23 ± 3 years, height: 175.5 ± 7.4 cm, body mass: 75.4 ± 7.5 kg) participated in this study. Countermovement jump (CMJ) height, isometric mid‐thigh pull peak force, 10 m sprint time and bench press and back squat repetitions to failure were assessed following CHO and placebo (PLA) rinsing or a control condition (CON). All testing took place at 07:30 following an 11 hour overnight fast. Performance of CMJ height (CHO: 39 ± 7 cm; PLA: 38 ± 7 cm; CON: 36 ± 6 cm; P = .003, = 0.40), 10 m sprint time (CHO: 1.78 ± 0.07 s; PLA: 1.81 ± 0.07 s; CON: 1.85 ± 0.05 s; P = .001, = 0.47), the number of bench press (CHO: 25 ± 3; PLA: 24 ± 4; CON: 22 ± 4; P < .001, = 0.55) and squat (CHO: 31 ± 4; PLA: 29 ± 5; CON: 26 ± 6; P < .001, = 0.70) repetitions and mean felt arousal (CHO: 5 ± 1; PLA: 4 ± 0; CON: 4 ± 0; P = .009, = 0.25) improved following CHO rinsing. However, isometric mid‐thigh pull peak force was unchanged (CHO: 2262 ± 288 N; PLA: 2236 ± 354 N; CON: 2212 ± 321 N; P = .368, = 0.08). These results suggest that oral CHO rinsing solution significantly improved the morning performance of CMJ height, 10 m sprint times, bench press and squat repetitions to failure and felt arousal, although peak force during an isometric mid‐thigh pull, rating of perceived exertion and heart rate were unaffected.
Communicative sensitivity in palliative care: a case on the “Happiness Angels” of Rajbala Foundation
Authors: Shukla Sangeeta , Sinha Saloni 
Published: June 2017

Subject area
The subject areas are business communication, human resource management and health care.

Study level/applicability
The case was designed for use in a first-year MBA-level course in business communication but would serve well in a course for executives or for advanced undergraduates. It might also be assigned in general management courses to evoke discussion on communication skills required in sensitive and critical situations; human resource courses; and course on health care.

Case overview
Palliative care is a specialized medical care focussing on improving the quality of life of patients suffering from life-threatening illnesses. It addresses symptom management and psychosocial and spiritual concerns of the patient and its caregivers. With the intent to alleviate the sufferings of terminally ill patients, Rajbala Foundation, a non-government organization (NGO), works at the psychosocial and spiritual levels. While training their volunteers in effective palliative care communication, it often encounters challenges such as socio-cultural variations, organizational challenges, appropriate verbal and nonverbal communication, etc. This teaching case focuses on the communication challenges faced by the volunteers of Rajbala Foundation. It would lead to a broader discussion on communicating empathically during critical situations. The case has a focus on NGOs, and non-profit organizations, public sector management, health-care management and human resources management. There is significant literature on communication skills for medical practitioners in palliative care. As an increasing number of NGOs step in to provide the second level of care to critically ill patients in non-physical domains, there is a need to understand the role of effective communication for such care providers. This case deals with non-medical care providers in palliative care; the issues of communication they face as they interact with patients; and the skills they require to address the emotional and spiritual needs of patients and their families.

Expected learning outcomes
The aim of this case is to raise awareness of the complexities involved in the communication process during an emotional and sensitive interaction. It aims to encourage volunteers involved in palliative care to reflect on good communication practices when communicating with patients and family members. After reading this case, the students should be able to discuss the complexities involved in the communication process when communicating in situations with high emotional involvement; understand the core elements of emotional interactions for effective practice; and emphasize the need for the development of communication skills within palliative care.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 6: Human Resource Management
Overcoming the HR challenge: a case of merger of Kotak Mahindra Bank and ING Vysya Bank
Authors: Jain Neena Rohit , Jaisinghani Dinesh 
Published: June 2017

Subject area
Human Resources and Organizational Behavior – dealing with the HR issues in mergers and acquisitions (M&As).

Study level/applicability
MBA and other similar programs at the post-graduation level.

Case overview
The current case deals with human resource (HR) issues in the merger of Kotak Mahindra Bank (KMB) and ING Vysya Bank (IVB). The case discusses various aspects of the merger process and focuses on the key challenges that firms face while integrating the employees of the merged entities. The case also highlights the steps taken by KMB to ensure that the merger process is smooth and employees are adequately motivated. The case also discusses the process adopted by the merged entity to efficiently integrate the employees.

Expected learning outcomes
The case can be a part of an organizational behavior course and a banking course. The current case allows students to make decisions while dealing with situations pertaining to employees’ integration in an M&A deal. The major expected learning outcomes of the current case include being able to: understand industry structure using the Indian banking industry as a case in point; identify the major challenges in any M&A deal; list down key HR issues in any merger activity; analyse strategies that can be adopted to deal with HR challenges; and construct a plan of action for integrating employees in a merged entity.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS: 6: Human Resource Management.