bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agritourism as a strategy of remote island’s development: the case study of Kasos
Authors: Vythoulka Anastasia , Kaliakmanis Fotis , Delegou Ekaterini , Giannikouris Antonis , Kampanis Nikolaos , Alexandrakis Georgios , Moropoulou Antonia , Chlorokostas Stavros , Magkoufis Efthymios , Kontopoulos Christos , Charalampopoulou Vasiliki 
Published: September 2024

In rural, depopulated areas, agritourism, as a development model, could serve the goal of non- exclusively seasonal tourism while creating additional economic opportunities for the locals who are mainly engaged in agriculture. Kasos is an isolated island of the Dodecanese, Greece, preserving interesting elements of the authentic agricultural practices and architecture like terraces serving the island’s agricultural cultivation, mills and mitata, small stone- built creameries.
Kasos served as a case study of AEI program (Sustainable Development of Less Developed Regions and Isolated Areas by Creating New Touristic Resources and Products through Analysis, Documentation and Modelling of Cultural Assets using Innovative ICT Applications, project code:T2EDK- 01278). For thιs island that lies within the wider region of Rhodes, it is possible with the appropriate development of new touristic resources and products through the advancement of the unique architectural, cultural and environmental assets to orient towards them special parts of the touristic flow from Rhodes, creating new touristic activity by increasing the residence beyond the daily or short time tourism, as it stands for now.
For the analysis of the study area, research in local archives and communication with the municipality and local stakeholders was conducted. Thus, both the special features of the island and the needs of the local community were identified, organized, classified and presented in GIS maps. The implementation of a GIS for Kasos Island aims to provide a comprehensive representation of the different aspects of the island, providing useful information for policy-making and the development of strategic cultural and agrotourism plans to the local authorities and stakeholders.
According to the integrated plan for Kasos by AEI program, the island could preserve its special rural identity while revealing its cultural and environmental assets and attracting external economies within an agritourism model. In this work, we present AEI’s integrated plan for Kasos that refers to the island’s agricultural character, to the existing trail network as well as to the restoration and adaptive reuse of important architectural assets that could serve to the overall revealing of Kasos history and cultural reserve.
Extracellular Vesicle–Packaged ACSL4 Induces Hepatocyte Senescence to Promote Hepatocellular Carcinoma Progression
Authors: Hou Pei-pei , Zheng Chong-ming , Wu Si-hong , Liu Xi-xiao , Xiang Guang-xin , Cai Wei-yang , Chen Gang , Lou Yong-liang 
Published: September 2024

Abstract
Extracellular vesicles (EV) derived from cancer cells are crucial mediators of intercellular communication during tumor progression. The cargo in tumor-derived EVs that facilitates the establishment of a tumor-supportive microenvironment could serve as a therapeutic target to improve cancer treatment. Here, we demonstrated that hepatocellular carcinoma (HCC) cells secreted the acyl-CoA synthetase long-chain family member 4 (ACSL4) in large EVs (lEV) to modulate tumor–microenvironment interactions that promote HCC progression. HCC-derived lEV ACSL4 increased the intracellular abundance of polyunsaturated fatty acid–containing lipids and remodeled the lipid profile to potentiate lipid peroxidation in peritumoral hepatocytes, resulting in hepatocyte senescence accompanied by the senescence-associated secretory phenotype. Depletion of senescent hepatocytes by senolytic treatment suppressed tumor progression. In HCC cells, SREBP2-mediated transcriptional activation upregulated ACSL4 expression, and Akt-mediated phosphorylation of ACSL4 induced its packaging into lEVs by augmenting its interaction with Annexin A2. This study identified the critical regulatory function of ACSL4 secreted from HCC cells in inducing lipid remodeling and senescence in hepatocytes to support HCC progression, suggesting that targeting lEV ACSL4 is a potential therapeutic strategy for HCC.
Significance: Peritumoral hepatocyte senescence mediated by ACSL4 secreted from hepatocellular carcinoma cells in extracellular vesicles promotes tumor progression through a senescence secretome and represents a therapeutic target in liver cancer.
Neural Circuitries between the Brain and Peripheral Solid Tumors
Authors: Chen Xiang , Geng Yuli , Wei Guanxin , He Danzeng , Lv Jialong , Wen Wenhao , Xiang Fan , Tao Kaixiong , Wu Chuanqing 
Published: September 2024

Abstract
The recent discovery of the pivotal role of the central nervous system in controlling tumor initiation and progression has opened a new field of research. Increasing evidence suggests a bidirectional interaction between the brain and tumors. The brain influences the biological behavior of tumor cells through complex neural networks involving the peripheral nervous system, the endocrine system, and the immune system, whereas tumors can establish local autonomic and sensory neural networks to transmit signals into the central nervous system, thereby affecting brain activity. This review aims to summarize the latest research in brain–tumor cross-talk, exploring neural circuitries between the brain and various peripheral solid tumors, analyzing the roles in tumor development and the related molecular mediators and pathologic mechanisms, and highlighting the critical impact on the understanding of cancer biology. Enhanced understanding of reciprocal communication between the brain and tumors will establish a solid theoretical basis for further research and could open avenues for repurposing psychiatric interventions in cancer treatment.
Understanding and Overcoming Resistance to Selective FGFR Inhibitors across FGFR2-Driven Malignancies
Authors: Facchinetti Francesco , Loriot Yohann , Brayé Floriane , Vasseur Damien , Bahleda Rastislav , Bigot Ludovic , Barbé Rémy , Nobre Catline , Combarel David , Michiels Stefan , Italiano Antoine , Smolenschi Cristina , Tselikas Lambros , Scoazec Jean-Yves , Ponce-Aix Santiago , Besse Benjamin , André Fabrice , Olaussen Ken A. , Hollebecque Antoine , Friboulet Luc 
Published: September 2024

Abstract

Purpose:
Understanding resistance to selective FGFR inhibitors is crucial to improve the clinical outcomes of patients with FGFR2-driven malignancies.

Experimental Design:
We analyzed sequential ctDNA, ± whole-exome sequencing, or targeted next-generation sequencing on tissue biopsies from patients with tumors harboring activating FGFR2 alterations progressing on pan-FGFR–selective inhibitors, collected in the prospective UNLOCK program. FGFR2::BICC1 Ba/F3 and patient-derived xenograft models were used for functional studies.

Results:
Thirty-six patients were included. In cholangiocarcinoma, at resistance to both reversible inhibitors (e.g., pemigatinib and erdafitinib) and the irreversible inhibitor futibatinib, polyclonal FGFR2 kinase domain mutations were frequent (14/27 patients). Tumors other than cholangiocarcinoma shared the same mutated FGFR2 residues, but polyclonality was rare (1/9 patients). At resistance to reversible inhibitors, 14 residues in the FGFR2 kinase domain were mutated—after futibatinib, only the molecular brake N550 and the gatekeeper V565. Off-target alterations in PI3K/mTOR and MAPK pathways were found in 11 patients, often together with on-target mutations. At progression to a first FGFR inhibitor, 12 patients received futibatinib or lirafugratinib (irreversible inhibitors), with variable clinical outcomes depending on previous resistance mechanisms. Two patients with TSC1 or PIK3CA mutations benefited from everolimus. In cell viability assays on Ba/F3 and in pharmacologic studies on patient-derived xenografts, irreversible inhibitors retained better activity against FGFR2 kinase domain mutations, with lirafugratinib active against the recalcitrant V565L/F/Y.

Conclusions:
At progression to FGFR inhibitors, FGFR2-driven malignancies are characterized by high intra- and interpatient molecular heterogeneity, particularly in cholangiocarcinoma. Resistance to FGFR inhibitors can be overcome by sequential, molecularly oriented treatment strategies across FGFR2-driven tumors.
СТАТЕВІ ОСОБЛИВОСТІ РОЗВИТКУ ОКСИДАТИВНОГО СТРЕСУ В ПЕЧІНЦІ ПІД ВПЛИВОМ КРАНІОСКЕЛЕТНОЇ ТРАВМИ ТА ЙОГО КОРЕКЦІЯ
Authors: ГУК Р. А. , ГУДИМА А. А. 
Published: September 2024

Мета роботи: зʼясувати вплив експериментальної краніоскелетної травми на розвиток оксидативного стресу в печінці у щурів різної статі та оцінити ефективність 2-етил-6-метил-3-гідроксипіридину сукцинату в корекції виявлених порушень.
Матеріали і методи. В експериментах використано 78 білих щурів-самиць та 78 білих щурів-самців лінії Вістар масою 200–220 г. В умовах тіопенталонатрієвого наркозу в дослідній групі 1 моделювали краніоскелетну травму, у дослідній групі 2 щурам з краніоскелетною травмою проводили корекцію розчином 2-етил-6-метил-3-гідроксипіридину сукцинату. Контрольних щурів різної статі тільки вводили в наркоз. Щурів дослідної групи 1 виводили з експерименту через 1, 3, 7, 14 та 28 діб після моделювання травми. Щурів дослідної групи 2 виводили з експерименту через 7, 14 та 28 діб посттравматичного періоду. Для дослідження брали печінку, в гомогенаті якої визначали каталазну активність та вміст реагентів до тіобарбітурової кислоти. За їх співвідношенням розраховували антиоксидантно-прооксидантний індекс, величина якого свідчить про розвиток оксидативного стресу в печінці.
Результати. Під впливом модельованої травми у щурів-самців максимальне зниження величини антиоксидантно-прооксидантного індексу в печінці відмічали через 3 доби експерименту, у щурів-самиць – через 7 діб, з наступним підвищенням, яке у щурів обох статей до 28 доби не досягало рівня контролю. У всі терміни посттравматичного періоду величина показника була статистично вірогідно більшою у щурів-самиць, порівняно зі щурами-самцями. Під впливом 2-етил-6-метил-3-гідроксипіридину сукцинату, порівняно зі щурами без корекції, порушення величини антиоксидантно-прооксидантного індексу печінки виявилися меншими, що у щурів-самиць було статистично вірогідним через 7 діб експерименту, у щурів-самців – через 7, 14 та 28 діб експерименту. Отже, інтенсивність прооксидантних механізмів у відповідь на травму в печінці у щурів-самців є більшою, ніж у щурів-самок, проте ефективність 2-етил-6-метил-3-гідроксипіридину сукцинату у щурів-самців є вищою.
СТАТЕВІ ОСОБЛИВОСТІ РОЗВИТКУ ОКСИДАТИВНОГО СТРЕСУ В СЕРЦІ ЩУРІВ ІЗ МЕТАБОЛІЧНО АСОЦІЙОВАНОЮ СТЕАТОТИЧНОЮ ХВОРОБОЮ ПЕЧІНКИ І КОРЕКЦІЄЮ ЇЇ ПРЕПАРАТАМИ ІНОЗИТОЛУ
Authors: ЛЕВЧУК О. О. , ДЕНЕФІЛЬ О. В. 
Published: September 2024

Мета роботи: вивчити особливості змін продуктів пероксидного окиснення ліпідів і антиоксидантної системи та прослідкувати морфологічні зміни у серці щурів різної статі із метаболічно асоційованою стеатотичною хворобою печінки (МАСХП) та при корекції патологічного процесу інозитолом.
Матеріали і методи. Досліди виконано на 96 щурах різної статі. Тварин поділено на 4 групи – контроль, МАСХП 4 місяці, МАСХП 4 місяці + міо-інозитол, МАСХП 4 місяці + D-chiro-інозито. У групі МАСХП 4 (2 група) тварини споживали замість води 20 % розчин фруктози протягом 4 місяців. Через 2 місяці від початку експерименту протягом 2 місяців їм інтрагастрально вводили міо-інозитол (400 мг/кг) або D-chiro-інозитол (30 мг/кг), відповідно 3 і 4 групи. Проводили забір серця для морфологічного і біохімічного досліджень; у гомогенаті серця визначали вміст дієнових і трієнових кон’югатів, основ Шиффа, ТБК-активних продуктів, супероксиддисмутазну і каталазну активність.
Результати. У серцях контрольної групи щурів-самців відмічено більшу активність процесів пероксидного окиснення ліпідів, порівняно з самицями. Метаболічно асоційована стеатотична хвороба печінки викликає активацію процесів пероксидного окиснення ліпідів, причому в самців зростають у більшій мірі первинні продукти пероксидного окиснення ліпідів та антиоксидантна активність, а в самиць – вторинні та кінцеві продукти пероксидного окиснення ліпідів. Інозитоли спричиняють зменшення оксидативного стресу в тварин обох статей. Морфологічна картина препаратів серця підтвердила виявлені біохімічні зміни.
Discovery of the male of Augochloropsis (Glyptochlora) Moure (Hymenoptera, Apidae, Halictinae), with a revised diagnosis for the subgenus
Authors: Celis Cindy Julieth , Raemakers Ivo , Melo Gabriel A. R. 
Published: September 2024

Augochloropsis (Glyptochlora) Moure is a morphologically homogeneous and rare subgenus of Augochlorini, endemic to the Amazon Basin. So far, the subgenus was known only from females. Herein, we identified and studied the male of Augochloropsis (Glyptochlora) peruviana Celis & Melo. This specimen represents the first opportunity to document the male morphology of Augochloropsis (Glyptochlora). In addition to the description of the male, including genital capsule and metasomal sterna, we provide an updated diagnosis for A. (Glyptochlora).
Exploring the Many Tunings of Balinese Gamelan
Authors: Sethares William , Vitale Wayne 
Published: September 2024

Abstract
The study of gamelan tunings has a long history, both within Indonesia and among the many foreign researchers who have sought to reconcile those tuning systems with ideas and practices of Western music. Challenges arise because Indonesian gamelan and Western tuning systems are based on fundamentally different concepts and principles. This article introduces and describes the Gamelan Tuning Explorer (GTE), a Max patch intended to help facilitate, through visualization and adjustable parameters, greater understanding of certain core aspects of Balinese gamelan tuning—specifically, the nonstandardized tunings used for gamelan gong kebyar, a large orchestra of bronze-keyed metallophones, tuned gongs, and other instruments. The GTE incorporates measured tuning data from 47 complete gamelan gong kebyar; each encompasses about 150 keys and tuned gong chimes. Forty-two of these tuning data sets were collected in the mid 1970s by American ethnomusicologist Andrew Toth, who spent decades in Bali engrossed in research on this topic; five were remeasured by the authors in 2019 to document how they had changed over the ensuing decades. In addition to collecting this treasure trove of data, Toth identified several key conceptual ideas of Balinese gamelan tunings. These include the consistent use of ombak (the prominent beating of two paired notes played in “unison”); the relationship of paired-tuning ombak to octave treatment; the stretching and compression of octaves, both by register and by note; the Begbeg versus Tirus models of intervallic formation; and more. Toth's data and each of these tuning concepts have been analyzed in two previous articles (Vitale and Sethares 2021; Sethares and Vitale 2022). We seek to make these concepts more immediate and accessible with GTE by using a graphical, interactive interface. Each of these parameters can be explored by the simple manipulation of a slider or other interface element. The corresponding changes in the sound can be readily heard, and visualized with interactive Toth plots—graphic representations of gamelan tuning profiles developed by Toth and named in his honor. This article describes a series of observations enabled by GTE.
‘To Adopt the Principles of Freedom’: Christianity, Women’s Education, and Progress in U.S. Press Coverage of the Iwakura Mission
Authors: Henning Joseph M. , Makalsky Leo 
Published: September 2024

Abstract
In U.S. press reports, the visit of Meiji Japan’s Iwakura Mission in 1872 presented both an opportunity for Americans to facilitate progress in Japan and evidence of social reform already underway there. As an opportunity, the mission served as a potential medium for American efforts to improve the Meiji government’s treatment of Japanese Christians. Many American political and religious leaders hoped to convince the mission ambassadors that freedom of religion was an essential component of civilization and a prerequisite for engaging with the treaty powers on equal terms. As evidence of social reform, the five Japanese girls who came with the mission to study in the United States embodied Japan’s new commitment to expanding educational opportunities for women. Focusing on the themes of religion and gender in U.S. newspaper coverage, this article shows how Americans projected onto the Iwakura Mission their own images of the United States as an inspiration and model for reform in Japan. Treating the mission as both an opportunity and evidence, the U.S. press depicted it in a self-congratulatory fashion to embellish Americans’ national identity as a people committed to progress.
Iwakura Mission and the Network of Japanese Students in the United States
Authors: Wakabayashi Haruko 
Published: September 2024

Abstract
One notable characteristic of the Iwakura Mission was, in Tanaka Akira’s words, its historical and cultural “continuity in discontinuity.” While its leaders were mostly from the aristocracy and the powerful Satsuma and Chōshū domains with little experience in the West, the secretaries who assisted them were former Tokugawa retainers that were experts in foreign affairs. The ryūgakusei, or overseas students, who were in the United States or Europe prior to the mission’s arrival and joined them on site, were another group that exemplified the “continuity.” Reform-minded daimyo and the progressive members of the Tokugawa regime had dispatched many to the West during the Tokugawa period with the very purpose to become useful servants to assist Japan’s quick and successful modernization. Once recruited to the mission, these ryūgakusei served as guides, interpreters, and investigators, collecting and compiling information on various institutions and policies in the respective countries. The knowledge, experience, and linguistic skills they had acquired and the network they created while abroad were vital in facilitating the Iwakura Mission and the new Meiji government’s subsequent effort of modernization.
Missed opportunities to provide sexually transmitted and blood-borne infections testing in British Columbia: An interpretive description of users’ experiences of Get Checked Online's design and implementation
Authors: Iyamu Ihoghosa , Kassam Rosemin , Worthington Catherine , Grace Daniel , Pedersen Heather , Haag Devon , Bondyra Mark , Salmon Amy , Koehoorn Mieke , Gilbert Mark 
Published: September 2024

Background Digital testing services for sexually transmitted and blood-borne infections (STBBIs), such as GetCheckedOnline, experience significant user drop-offs. For example, 32% of GetCheckedOnline users needing testing at account creation do not test, constituting missed opportunities. We explored the influence of users’ expectations and experiences of GetCheckedOnline's web design and implementation on missed opportunities. Methods This interpretive description purposively sampled 14 GetCheckedOnline users who created accounts between April 2022 and February 2023, indicated needed testing at account creation but did not test. We conducted semi-structured interviews and cognitive walkthroughs of GetCheckedOnline on Zoom, exploring participants’ expectations and experiences, including problems using the service. Interviews were audio recorded, transcribed verbatim, and analyzed using reflexive thematic analyses. Results Three themes were identified: (a) transitioning between GetCheckedOnline and laboratory services is a major testing barrier; (b) users’ appraisal of their health and social contexts is a determinant of testing through GetCheckedOnline; and (c) tailoring GetCheckedOnline's design and implementation to accommodate varying user needs can promote equitable testing. Health equity issues occurred along sociodemographic gradients as the GetCheckedOnline-laboratory transition was more onerous for older users. Users’ appraisal of their testing needs which varied by age and gender, and their assessment of time, and travel requirements for testing in remote communities influenced testing. Learning about GetCheckedOnline from healthcare providers improved testing compared with learning about the service through Google search which raised trust concerns regarding GetCheckedOnline's authenticity. Suggested improvements to promote health equity include personalized education, mail-in testing options, and simpler seamless web experiences. Conclusions To promote equitable access to digital STBBI testing services such as GetCheckedOnline, we can adapt web-design and implementation to suit user needs and contexts, ensuring simplicity and options for testing that reduce user burdens.
Clinical features, pathophysiology, and management of acute myelopathy following CAR T-cell therapy
Authors: Deschênes-Simard Xavier , Santomasso Bianca D. , Dahi Parastoo B. 
Published: September 2024

Abstract
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of patients with relapsed or refractory hematologic malignancies, but it comes with unique toxicities, notably cytokine release syndrome and ICANS (immune effector cell–associated neurotoxicity syndrome). As experience with CAR T-cell therapy grows, distinct and infrequent neurologic complications are becoming increasingly evident. Recently, reports of acute myelopathy after the administration of CAR T-cell therapies have been accumulating. Despite the establishment of consensus guidelines for managing ICANS, there remains limited guidance on the appropriate investigations and treatments for this rare complication. In this manuscript, we delve into the clinical features, pathophysiology, and strategies for the optimal management of acute myelitis after CAR T-cell therapy and draw insights from reported cases in the literature.