bluuebunny/crossref_metadata_2025_split huggingface dataset:
TREINAMENTO MUSCULAR INSPIRATÓRIO APLICADO EM PACIENTES COM DOENÇA PULMONAR OBSTRUTIVA CRÔNICA: REVISÃO INTEGRATIVA
Authors: Lins Freitas Annicia , Maria Lacerda de Oliveira Carneiro Hellen , Flechas Arruda Perdigão Kauane , Pedrosa Rafaela , Heriston de Morais Lima José , Eriko Tenório de França Eduardo 
Published: October 2024

Introdução: A doença pulmonar obstrutiva crônica (DPOC) é uma obstrução das vias aéreas, que impossibilita a respiração adequada e ocasiona diferentes disfunções no corpo humano. Objetivo: Avaliar os efeitos do treinamento muscular inspiratório (TMI) em pacientes com DPOC, visando identificar, na literatura científica, as estratégias contemporâneas empregadas e seus resultados. Métodos: Revisão de escopo da literatura, abordando as formas de aplicação do TMI, bem como a carga, frequência e seus efeitos. Foram incluídos artigos dos últimos 5 anos, abrangendo ensaios clínicos. As bases de dados consultadas foram a Cochrane, Lilacs, Medline e Pubmed. Os descritores foram “COPD”, “Breathing Exercises”, e “Respiratory Muscle Training”, e o operador booleano “and”. Os dados extraídos foram organizados em instrumentos elaborados pelos autores. Resultados: Nove artigos selecionados mostraram que o programa de reabilitação pulmonar envolvendo o TMI oferta efeitos positivos quando comparados com programa de reabilitação pulmonar sem TMI. Geralmente, os treinamentos ocorrem num período de 3 a 8 semanas, 3 a 5 vezes por semana, e a carga é a partir de 30% da pressão inspiratória máxima, sendo aumentada progressivamente conforme as adaptações dos pacientes. Conclusão: Os estudos apontaram que o TMI no programa de reabilitação pulmonar entrega resultados significantes quanto a dispneia, capacidade funcional, força muscular inspiratória, padrão ventilatório, modulação autonômica cardíaca, equilíbrio, marcha e qualidade de vida.
Más allá del título y modo: transferencia de propiedad en el Perú a 40 años del Código Civil de 1984
Authors: Arribas Irazola Guillermo José 
Published: October 2024

Luego de 40 años de vigencia del Código Civil de 1984, el autor revisa y cuestiona el grupo de normas que regulan la transferencia de la propiedad en el Perú. Teniendo en especial consideración el hecho de que las reglas generales de transferencia de propiedad en el libro de Derechos Reales no han tenido ninguna modificación desde su emisión en 1984, el autor desarrolla estas normas junto con aquellas que complementan nuestro sistema de transferencia de propiedad, y las principales discusiones que se han dado sobre estas materias en los últimos 40 años.En cada caso, se evalúa la coherencia del sistema y la relevancia de potenciales modificaciones. El autor propone reformas concretas a esta sección del Código Civil con el objetivo de asegurar la adaptabilidad de las normas de transferencia de propiedad a nuevos tiempos.
El carácter de las normas sobre la interpretación de los contratos
Authors: Forno Flórez Hugo 
Published: October 2024

Las cláusulas de interpretación de los contratos son herramientas otorgadas por el Código Civil. La discusión sobre el carácter que poseen (imperativas o meras sugerencias) ha sido un largo debate doctrinario e incluso legislativo. El autor mediante un recorrido histórico y teórico de esta institución alrededor del mundo, pero sobre todo de las legislaciones europeas –que son la influencia de la nuestra–se pronuncia al respecto y sostiene que existe, en realidad, una dualidad en la naturaleza de estas normas (imperativas y dispositivas), puesto que estas categorías, en el contexto en el que han sido usadas, no serían mutuamente excluyentes.La importancia de entender de este modo estas reglas radica en que solo así se logra un balance entre la seguridad jurídica y la libertad contractual.
Comentarios a la legislación y a la jurisprudencia del contrato de arrendamiento en el Perú a los 40 años de vigencia del Código Civil
Authors: Villota Cerna Marco 
Published: October 2024

El presente artículo realiza un análisis de la regulación del contrato de arrendamiento en el Código Civil y normas conexas, desde un punto de vista de la jurisprudencia y del derecho comparado, para sugerir algunos cambios normativos o criterios de interpretación a los 40 años de vigencia del Código Civil peruano. El trabajo analiza la relación entre el arrendamiento y el derecho de posesión para distinguirlo del derecho real de uso y de usufructo; trata el subcontrato de arrendamiento para delimitar las responsabilidades del subarrendatario y sobre todo, se centra en el tema de la duración del contrato de arrendamiento, a propósito de la discusión si el arrendatario con contrato vencido tiene la calidad de ocupante precario. Finalmente, analiza las diversas formas de conclusión del contrato de arrendamiento, las causales del proceso de desalojo y las diversas clases de proceso, a fin de hacer más ágil el proceso de desalojo.
La donación remuneratoria: una aproximación crítica a su naturaleza y a sus alcances
Authors: Bautista Quispe Ulises 
Published: October 2024

La donación remuneratoria tiene un tratamiento parcialmente diferente al de una donación ordinaria; no se le aplican las normas de la revocación ni las de la obligación de alimentos (entre ellas las normas que protegen la legítima). Sin embargo, en el Código Civil se omite tal tratamiento y existe una tendencia a equipararla a un acto oneroso o a un pago, lo cual no es raro encontrar también en varios sectores de la doctrina nacional y extranjera.El autor critica estas posturas, señalando varias deficiencias, y sostiene que la donación remuneratoria es un subtipo de donación que se celebra de manera libre. Además, argumenta que la donación remuneratoria no debe ser equiparada con los intereses mercantiles, dada su esencia y los valores que promueve. Asimismo, ante la laguna legal en el Código Civil, el autor identifica y precisa el alcance que debería tener este contrato.
Limitaciones a la propiedad. En las limitaciones privadas: ¿el Tribunal Registral tiene facultad para legislar?
Authors: Ortiz Pasco Jorge 
Published: October 2024

El artículo desarrolla la diversidad de limitaciones al derecho de propiedad en el Perú, muchas de ellas pasadas por alto, pero muy necesarias de conocer. En esta tarea, el autor también se posiciona frente a la polémica restricción en la transferencia y gravamen de bienes por acuerdo entre privados.Sobre algunas limitaciones se ha pronunciado la máxima instancia administrativa registral: el Tribunal Registral; el autor cuestiona su facultad legislativa mediante un análisis de los cambios que han propiciado los plenos LXII, XCIV y XCIX, además de los pronunciamientos de Tribunal Constitucional y lo establecido en el Código Civil de 40 años de vigencia.
Histopathology of liver, kidney, intestine, spleen, and bile of catfish with Jaundice
Authors: Asrido Farhan , Nuryati Sri , Widanarni Widanarni 
Published: October 2024

Jaundice is a disease that can affect catfish, resulting in low or unsalable selling prices. The yellow colour in catfish is associated with tissue/organ disorders, particularly bile or liver function. This study aims to compare the histopathological structure of the liver, kidney, intestine, spleen, and bile of naturally jaundiced catfish and those injected with bacteria associated with jaundice. The study employed the observation method, using three variables: healthy catfish as a control (K), yellow catfish treated with Aeromonas spp. bacteria associated with jaundice (KP), and yellow catfish from the farm (KL). The results of the observation showed that the field scale variable (KL) had a higher level of necrosis damage in each organ compared to the laboratory scale variable (KP). The yellow colour in catfish is caused by disrupted organ tissue, particularly in the bile or liver. This can be observed in the liver, intestines, kidneys, spleen, and bile, where the field variable consistently indicates high levels of necrosis damage, with scores ranging from 1.11 to 2.48. Some of these scores indicate moderate damage, with a necrosis percentage of 40% ≤ P < 60% in the liver, kidneys, and bile organs.
Keyword: Clarias sp., histopathology, jaundice, necrosis

ABSTRAK

Salah satu penyakit yang menyerang ikan lele adalah penyakit kuning atau dikenal juga dengan jaundice, yang dapat mengakibatkan harga jual menjadi rendah atau bahkan tidak dapat dijual. Warna kuning pada ikan lele dikaitkan dengan gangguan jaringan / organ, terutama empedu atau fungsi hati. Penelitian ini bertujuan untuk membandingkan struktur histopatologi organ hati, ginjal, usus, limpa, dan empedu ikan lele yang sakit kuning baik yang alami maupun yang diinjeksi dengan bakteri yang berasosiasi dengan penyakit kuning. Penelitian ini menggunakan metode observasi dengan tiga variabel yaitu ikan lele sehat sebagai kontrol (K), ikan lele kuning yang diberi perlakuan injeksi dengan bakteri yang berasosiasi dengan penyakit kuning yaiatu bakteri Aeromonas spp. (KP), dan ikan lele kuning yang berasal dari farm (KL). Hasil pengamatan yang diperoleh menunjukkan bahwa variabel skala lapangan (KL) memiliki tingkat kerusakan nekrosis paling tinggi pada setiap organnya dibandingkan dengan variabel skala laboratorium (KP). Warna kuning pada ikan lele berhubungan dengan terganggunya jaringan organ terutama empedu atau fungsi hati. Terlihat pada organ hati, usus, ginjal, limpa, dan empedu bahwa variabel lapangan selalu mendapatkan skor tingkat kerusakan nekrosis yang tinggi dengan kisaran nilai skoring 1,11-2,48 yang sebagian tergolong kerusakan sedang dengan persentase nekrosis 40% ≤ P<60% pada organ hati, ginjal, dan empedu.

Kata kunci: Clarias sp., histopatologi, nekrosis, penyakit kuning
Larval rearing of kelabau fish Osteochilus melanopleurus, Bleeker 1852 with different live feed
Authors: Asiah Nur , Aryani Netti , Heltonika Benny 
Published: October 2024

This study aimed to determine the effect of different starting feeds on the growth and survival rate of kelabau fish larvae (Ostechilus melanopleurus, Bleeker 1852). The research was conducted in a Complete Randomized Design (CRD), 3 treatments and 3 replicates. The tested animals used were 7-Dpc (Day post hatch) 90 kelabau fish (Ostechilus melanopleurus) larvae with an initial average length of 0.50 ± 0.06 cm and an initial weight of 0.03 ± 0.02 g. Treatment of one (P1) Artemia nauplii, (P2) Tubifex sp., and (P3) Daphnia. Aquarium research containers size 30×30×20 cm3 9 pieces with a volume of 5 L of water without water flow in the first week onwards from the second week to the 4th week are increased to 10 L with a water recirculation system with a water flow of about 0.5 L per minute. Measurement of the length and weight of the larvae is carried out once a week for 4 weeks. The results showed that the highest length and weight growth was obtained in the P2 treatment of 3.92 ± 0.13c cm and 1.25 ± 0.03c g, and the lowest growth was in the P3 treatment of 1.73 ± 0.05a cm and 0.093 ± 0.010a g. The ANOVA results showed that feeding Tubifex sp. had a very noticeable different effect with a value of P<0.01.

Keywords: feed type, Osteochilus melanopleurus, growth

ABSTRAK

Penelitian ini bertujuan untuk mengetahui pakan awal berbeda terhadap pertumbuhan dan kelulushidupan larva ikan kelabau (Ostechilus melanopleurus, Bleeker 1852). Metode Penelitian yang digunakan adalah metode eksperimen, dengan Rancangan Acak Lengkap (RAL), 3 perlakuan dan 3 ulangan. Hewan uji yang digunakan adalah larva ikan kelabau (Ostechilus melanopleurus, Bleeker 1852) umur 7 hari sebanyak 90 ekor dengan rata-rata panjang awal 0,50 ± 0.06 cm dan berat awal 0.03 ± 0.02 g. Perlakuan satu (P1) Nauplii Artemia, (P2) Tubifex sp. dan (P3) Kutu Air. Wadah penelitian akuarium ukuran 30×30×20 cm3 9 buah dengan volume 5 L air tanpa aliran air pada minggu pertama dan seterusnya dari minggu kedua sampai minggu ke 4 ditambah menjadi 10 L dengan sistem resirkulasi air dengan aliran air sekitar 0.5 L per menit. Pengukuran panjang dan bobot larva dilakukan seminggu sekali, selama 4 minggu. Hasil penelitian menunjukkan bahwa pertumbuhan panjang dan berat tertinggi ditunjukkan pada perlakuan P2 sebesar 3.92 ± 0.13c cm dan 1.25 ± 0.03c g, dan pertumbuhan terendah yaitu pada perlakuan P3 1.73 ± 0.05a cm dan 0.093 ± 0.010a g. Hasil ANOVA menunjukan bahwa pemberian pakan Tubifex sp. memberikan pengaruh berbeda sangat nyata dengan nilai P<0.01.

Kata kunci: Osteochilus melanopleurus, pertumbuhan, tipe pakan
ANALYSIS OF TUMBAORHYTHM PATTERNONCONGA IN NECESITAS TU
Authors: Margana Rangga , Saryanto  , Srimoko Gandung Joko , Retnowati Tjut Etty 
Published: October 2024

The purpose of this study is to describe the results of the Analysis TumbaoRhythm PatternonConga in Necesitas Tu. The research method used is qualitative with a descriptive approach. This research was carried out from October 2020 to June 2021. The results of the study can be concluded that the most popular Basic of Latin Cuban is the tumbao pattern. The tumbao pattern is the basic pattern for playing conga in salsa music. In the song Necesitas Tu there are two types of variations of the tumbao pattern, namely: variation I and variation II. It can be concluded that the song Necesitas Tu by Blue Mambo has 9 (nine) parts, namely: intro, main theme, development section, interlude, solo, intro, main theme, development section, and coda. The section that has more than one variation of the tumbao rhythm pattern is the development section. Overall there are 4 (four) techniques used in the tumbao pattern such as heel, fingertip/toe, slap, and open tone. The implication of the results of this study is to explore conga instruments that are of interest in developing percussion skills. Music education institutions are to provide adequate facilities so that students are more active in exploring conga instruments, so that students are motivated to improve their abilities or skills in processing Latin percussion instruments as well as Indonesian ethnic percussion.
Successful Long-Term Management of NF1 Congenital Tibial Dysplasia with Prophylactic Bypass Graft and Bracing
Authors: Burgess Regan K. , Crawford Alvin H. , Mehlman Charles T. 
Published: October 2024

Case:
An 8-year-old girl with NF1 and congenital tibial dysplasia with significant bilateral tibial bowing underwent McFarland procedures. Now age 22 with 14-year follow-up indicating sustained correction and healing of her bilateral limb deformities.

Conclusion:
This case illustrates the McFarland procedure provided adequate corrective treatment of this deformity and remains a success at long-term follow-up.
POTABILIDADE DA ÁGUA DE POÇOS E OS SERVIÇOS DE ABASTECIMENTO HÍDRICO DA REGIÃO DO MÉDIO SOLIMÕES, AMAZONAS
Authors: Pinho Barbosa Milena , Capeleto de Andrade Leonardo , Rosinski Lima Gomes Maria Cecília 
Published: October 2024

As águas subterrâneas têm se tornando a principal fonte de abastecimento hídrico das cidades brasileiras, onde o número real de poços existentes no país torna-se inconclusivo. No estado do Amazonas, apesar da grande disponibilidade de águas dos rios, as cidades preferem utilizar-se das águas subterrâneas. O objetivo do estudo foi avaliar os serviços abastecimento e a potabilidade da água de municípios totalmente abastecidos por águas subterrâneas no Médio Solimões. Foram utilizados banco de dados dos Sistema de Informações de Águas Subterrâneas (SIAGAS) e do Instituto de Proteção Ambiental do Amazonas (IPAAM) e realizadas entrevistas com os gestores dos serviços de abastecimento. As amostras de água foram coletadas em oito poços de cada município e a análise microbiológica foi desenvolvida pela contagem direta de unidades formadoras de colônias de coliformes totais e Escherichia coli, utilizando o método de filtração por membrana de nitrocelulose. Foram identificados um total de 160 poços nos municípios no sistema do SIAGAS e 14 outorgas concedidas pelo IPAAM. Segundo as entrevistas concedidas, nenhum dos poços operados pelos serviços possuem registros nessas plataformas, encontrando-se irregulares. Em todos os poços analisados houve a presença de coliformes totais e em 75% das amostras houve contaminação por E. coli., estando fora do limite de potabilidade. A deficiência do sistema de abastecimento público faz com que a população se utilize de uma grande quantidade de poços privados irregulares para este suprimento. Todas as amostras foram consideradas não potáveis, em decorrência das concentrações de coliformes totais fora do padrão de potabilidade.
WITHDRAWN: The Difference in Fine Motor Performance Between Saudi Boys and Girls in Preschool Age: A Pilot Study
Authors: Alsakhawi Reham , Aleidi Jasmine , Almutairi Renad , Alrifaei Sara , Alnutifi Abeer , Almutiri Rawan 
Published: October 2024

Abstract

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
cfDNA Fragmentation Patterns Correlates with Tumor Burden Measured via PSMA PET/CT Volumetric Parameters in Patients with Biochemical Recurrence of Prostate Cancer
Authors: Amseian Gary , Figueras Marcel , Mases Joel , Mengual Lourdes , Ribal Maria-Jose , Quintero Katherine , Pages Rita , Ingelmo-Torres Mercedes , Roldan Fiorella-Lizzeth , Fuster David , Alcaraz Antonio , Izquierdo Laura , Paredes Pilar , Medicine CBNM Group Clinic Barcelona Nuclear 
Published: October 2024

Abstract

Background
Prostate cancer recurrence following primary treatment poses a significant clinical challenge, particularly when detected through biochemical recurrence at low PSA levels. Conventional imaging modalities often fail to localize the disease at this early stage. PSMA PET has demonstrated superior sensitivity in detecting recurrent lesions, even in patients with low PSA. Concurrently, liquid biopsy, through analysis of cell-free DNA (cfDNA), offers a minimally invasive approach for monitoring disease. There is scarce evidence about the association between liquid biopsy and PSMA PET/CT findings. This study aimed to assess the correlation between liquid biopsy and tumor burden assessed by PSMA PET/CT in early recurring prostate cancer patients.
Results
PSMA PET/CT and liquid biopsies of 32 patients in biochemical recurrence were analyzed. 12 patients (37.5%) had no PSMA PET-measurable disease. Four patients (12.5%) presented local recurrence, seven (21.9%) had recurrence in pelvic lymph nodes, one of whom also had local recurrence. Nine patients (28.1%) presented metastatic recurrence, with or without local or nodal recurrence. PSA levels correlated with molecular imaging data (p < 0.05), including wbPSMA-TV40, wbTL-PSMA40, wbSUVmean and wbSUVmax. The mean cfDNA fragment size fraction was inversely correlated with tumour burden measured with wbPSMA-TV, with a Spearman correlation coefficient of -0.451 and a p-value of 0.009. No correlation was found between cfDNA concentration and PET-PSMA data.
Conclusion
This prospective study demonstrated a statistically significant negative correlation between cfDNA fragmentation patterns and PSMA PET/CT volumetric parameters in localized prostate cancer patients with early biochemical recurrence. These findings underscore the potential of liquid biopsy as a biomarker and a complementary tool to PSMA PET/CT to assess disease progression during the follow-up of these patients.
Assessment of gingival blood flow changes due to orthodontic force using laser speckle contrast imaging: A randomized controlled trial
Authors: Yin Fan , Zhao Junwei , Zhang Hao , Wang Shusi , An Qi , Wei Xiaojiao , Tang Chenxin , Han Shuang 
Published: October 2024

Abstract

Background
This study aimed to measure gingival blood flow under different orthodontic forces using laser speckle contrast imaging (LSCI).
Methods
Forty eligible individuals were recruited and randomly assigned into two groups:50 g group and 150 g group. According to the groups, forces of 50 g or 150 g were applied from the maxillary canines to the first molars on the left or right sides of each participant. The canine area's blood flow (regions of interest (ROIs) 1, 2, 3, and 4) was measured using LSCI at different time intervals (baseline, 30 minutes, 1, 3, 7, and 14 days).
Results
Evaluation of blood flow between the groups revealed significant differences at ROI 1 at 1 day and 3 days; and at ROI 4 at 1 day and 3 days. Intra-group comparisons showed significant differences in blood flow within each group for each region at each time point (P<0.05). After applying orthodontic forces, blood flow reached its nadir within 30 minutes to 1 day. The 150 g group exhibited a more significant decrease compared to the 50 g group. Blood flow peaked at 3 days in the 50 g group and at 7 days in the 150 g group. Both groups finally returned to baseline at day 14. In the resting state without force loading, statistically significant differences in blood flow were observed among the marginal gingiva, attached gingiva, and interdental papilla. The marginal gingiva exhibited lower blood flow compared to other regions.
Conclusions
Laser speckle contrast imaging is a reliable tool for monitoring gingival blood flow in orthodontic treatment. Gingival blood flow decreased after force application, reaching peak values in 3 to 7 days and eventually returning to baseline within 14 days.
Trial registration
The trial was registered in Chinese Clinical Trial Registry (ChiCTR2400082438) on 29/03/2024.
How Do International Medical Students Make Sense of Internal and External Feedback to Improve Their Dutch Communication Skills?
Authors: Yu Hao , Li Zhien , Köhler S. Eleonore , Merriënboer Jeroen J. G. van , Asoodar Maryam 
Published: October 2024

Abstract

Background:
Feedback is crucial in medical education for developing communication skills and fostering comprehensive learning. Despite its importance, medical students often face challenges in effectively leveraging feedback. This study investigates how students make sense of internal and external feedback in a 2nd language (L2) medical Dutch course.
Methods:
Sixteen third-year international medical students (mean age = 23) participated in a medical Dutch course that included six structured sessions. Each session encompassed a briefing, simulated patient consultations (SPCs), and a debriefing. The curriculum integrated internal feedback from self-reflections and external feedback from peers, teachers, and simulated patients. Data were gathered through a students’ feedback perception survey and semi-structured interviews and analyzed via inductive thematic analysis.
Results:
Survey data indicated a trend where the preference, satisfaction, and trust in external feedback were higher than those for internal feedback. However, both types of feedback were regarded as equally effective in facilitating learning progress. Through thematic analysis, we identified five crucial themes that show how students perceive and make sense of various forms of feedback: proactive, dialogue and integration, holistic view on performance, value from diverse perspectives, and moment-specific and actionable feedback.
Conclusions:
This study underscores the vital roles of internal and external feedback in enhancing medical Dutch communication skills among medical students. Internal feedback encourages self-reflection and growth, essential for complex medical communications, while external feedback provides clear, specific and supportive guidance and experience from teachers, simulated patients and peers. These feedback mechanisms together improve students' skill in medical Dutch communication, leading to better doctor-patient interactions. Future research should focus on adapting these feedback strategies across diverse educational settings to further support the development of medical L2 communication skills in global medical contexts.