bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemisynthesis, Anti-Inflammatory, and In-silico Alpha-Amylase Inhibition of Novel Carlina Oxide Analogs
Authors: Hammoudi Amina , Zatla Amina Tabet , Mami Imane Rihab , Perard Joelle , Dib Mohamed El Amine 
Published: October 2024

Background:
Numerous natural products have been successfully developed for clinical
use in the treatment of human diseases in almost every therapeutic area.

Objective:
This work aimed to synthesize some new analogs of Carlina oxide by functionalizing the
fifth position of the furan by different acyl groups using the Friedel-Crafts acylation approach. The
synthetic analogs and carlina oxide were then assessed for their in-vitro anti-inflammatory activity
and in-silico alpha-amylase inhibition effect.

Methods:
The new analogs were synthesized at room temperature using different anhydrides with
the presence of boron trifluoride diethyl etherate (BF3-Et2O) as an acid catalyst. A protein denaturation
assay was performed to evaluate the anti-inflammatory activity, while the in-silico study was
conducted using the Molecular Operating Environment (MOE) with different types of alphaamylase
sources, such as human salivary pancreatic alpha-amylase and Aspergillus oryzae alphaamylase
(PDB: 1Q4N, 5EMY, 7P4W respectively).

Results:
A total of four analogs of carlina oxide were obtained in yields of 60-7% and then identified
with 1H and 13C NMR analysis. Additionally, analog 1 exhibited a better anti-inflammatory effect
with an IC50 of 0.280 mg/mL. However, the in-silico study showed that all the synthetic analogs
have different interactions with human salivary alpha-amylase (1Q4N) and other interactions
with 5EMY and 7P4W.

Conclusion:
The new analogs of Carlina oxide have the potential to serve as an alternative agent
for alpha-amylase inhibition, contributing to the reduction of postprandial hyperglycemia.
The Effect of Ginger (Zingiber Officinale Roscoe) and Turmeric (Curcuma Longa) Supplementation on 17-β Estradiol Level, Quality of Life and Body Composition in Postmenopausal Women: Secondary Outcomes of a Randomized, Placebo controlled Trial
Authors: Shakouri Seyed Kazem , Salekzamani Yaghoub , Dolatkhah Neda , Dolati Sanam , Hashemian Maryam 
Published: October 2024

Background:
Further investigation is required to deeply understand the role of traditional
medicines in menopause and their safe and effective usage.

Objective:
To determine the effects of Zingiber officinale roscoe [ZO] and Curcuma longa [CL]
supplementation on 17-β estradiol [ES] levels, quality of life, and body composition indices in
postmenopausal women.

Methods:
In this four-month randomized controlled trial, women were recruited from the Tabriz
health centers between 2018 and 2019 and randomly allocated to one of four groups: ZO tablet
1000 mg and CL placebo, CL tablet 1000 mg and ZO placebo, ZO tablet 1000 mg and CL tablet
1000 mg, and ZO placebo and CL placebo.

Results:
One hundred and fifteen women completed this study. ZO [mean change [MC] = 3.18
[95% CI: 0.55 to 5.81]] resulted in a greater increase in serum ES than placebo. ZO [MC= -1.26
[95% CI: -2.78 to -0.72]], CL [MC=-1.21 [95% CI: -2.79 to -0.53]] and ZO + CL [MC=-1.69
[95% CI: -2.48 to -0.85]] resulted in greater improvements in total quality of life score compared
to placebo [MC=-0.51[95% CI: -0.04 to 1.32]]. A significant group difference favoring the ZO
group compared to the placebo was detected for the vasomotor symptoms [MC= -1.03 [95% CI:
-2.57 to -0.97]]. No significant adverse events were noted.

Conclusion:
This study demonstrates the beneficial effects of ginger, turmeric, and ginger plus
turmeric supplementation on the quality of life of postmenopausal women.
Research on Coordination Optimal Scheduling Method for Integrated Energy System Based on Finite-time Event-triggered Consensus Algorithm
Authors: Wu Lizhen , Yang Heng , Chen Wei , Pei Tingting 
Published: October 2024

Background:
The coupling of multiple heterogeneous energy sources in an integrated
energy system has led to difficulties in coordinating the optimal scheduling of various energy
sources. As a typical cyber-physical system, the development scale of an integrated energy system
is limited by the communication bandwidth.

Objective:
A coordinated optimal scheduling method for integrated energy system based on finitetime
event-triggered consensus algorithm is proposed in this paper to achieve the optimal operation
of an integrated energy system and lower the burden on the communication network.

Methods:
In this paper, the optimal scheduling model of integrated energy system is established,
and the finite-time consensus algorithm is applied to solve the model, so that the operating costs
of various energy sources can reach the optimal solution within a finite time. Then, a discrete system
communication scheme is established so that neighbor nodes exchange state information only
at the triggering instants. The stability of the system is analyzed using the Lyapunov stability theory,
and it is verified that the system does not exhibit the Zeno phenomenon. Finally, the effectiveness
of the proposed optimal scheduling method is verified by case analysis.

Results:
The results show that the method can achieve the optimal operation of integrated energy
system and effectively reduce the number of communications between neighbor nodes, lowering
the burden on the communication network.

Conclusion:
An integrated energy system composed of electric-heating-gas-cooling is given to
verify the feasibility and effectiveness of the proposed method.
MENGANALISIS FAKTOR YANG MEMPENGARUHI PERMINTAAN KREDIT PEMILIKAN RUMAH
Authors: Prasetyo Achmad Budi , Pudjihardjo M 
Published: October 2024

The increasing need for housing encourages people take other alternatives, such as using Home Ownership Loans (KPR) as an alternative in obtaining housing. There are some factors that influence the community as consumers in taking / using mortgages, some factors include customer income, house prices, interest rates, down payments, loan terms, and the simultaneous influence of all factors. This study aims to provide an overview of the factors that influence the demand for mortgage loans in Watubangga urban village housing in Kendari city. The method used in this research uses descriptive quantitative, where this approach explains the phenomenon of the situation, measures the relationship and draws conclusions based on the use of numbers. The findings of this study are partial factors that affect mortgage credit such as customer income, price of a house and time period are positively significant, which means that the increase in these partial factors increases the community's intention to take out a mortgage. However, it is inversely proportional to partial factors such as interest rates and down payments. Even so, the effect of these factors is simultaneously positively significant.
El Imperio romano y el derecho tributario las causas de la caída del Imperio romano = The Roman Empire and tax law. The causes of the fall of the Roman Empire
Authors: Cozzo Villafañe Patricia A. 
Published: October 2024

En el presente trabajo procuro ver la influencia de los tributos durante el tiempo del Imperio romano. Como se aplicaban los tributos a los reinos conquistados sin tener en cuenta la capacidad contributiva de las personas. Como fue la evolución de los mismos a lo largo de la historia y hasta llegar a los tiempos del cristianismo y la reforma tributaria de Dioclesiano. Como influyo este sistema impositivo en la caída del Impero romano.
ABSTRACT: In the present work I try to see the influence of the tributes during the time of the Roman Empire. How taxes were applied to the conquered kingdoms without taking into account the taxpaying capacity of the people. How was their evolution throughout history and until reaching the times of Christianity and the tax reform of Diocletian. How did this tax system influence the fall of the Roman Empire
STRATEGI DINAS PENANAMAN MODAL DAN PELAYANAN TERPADU SATU PINTU DALAM MENINGKATKAN INVESTASI KABUPATEN BINTAN
Authors: Lestari Seli , Nazaki Nazaki , Putra Ardi 
Published: October 2024

Pemerintah memiliki peran untuk memfasilitasi perkembangan penanaman modal, salah satunya peran pemerintah daerah. Hal tersebut tidak lepas dari peran Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu untuk terus membuat strategi melalui program-program baru untuk meningkatkan pelayanan perizinan dan penanaman modal. Maka dari itu penelitian ini bertujuan untuk mengetahui bagaimana strategi Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu dalam meningkatkan investasi di Kabupaten Bintan. Peneliti menggunakan metode kualitatif. Adapun subjek dari penelitian ini yaitu kepala Dinas dan Kepala Bidang Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Kabupaten Bintan serta pihak investor atau pengusaha di Kabupaten Bintan. Peneliti menggunakan teknik pengumpulan data berupa wawancara serta dokumentasi. Hasil dari penelitian yaitu strategi DPMPSTPS untuk meningkatkan invetasi. Pertama perumusan strategi melalui visi misi yang tercantum dalam Renstra. Kedua Implementasi strategi melalui program-program DPMPTSP Kabupaten Bintan yaitu: Program Pengembangan Penanaman Modal, Program Promosi Penanaman Modal, Program Pelayanan Penanaman Modal, Program Pengendalian Pelaksanaan Penanaman Modal dan Program Pengelolaan Data dan Sistem Informasi Penanaman Modal. Terakhir Evaluasi Strategi berupa evaluasi kinerja untuk program yang telah terlaksana. Adapun kendala yang masih Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu rasakan saat ini yaitu masih adanya ketimpangan peraturan dengan pemerintah pusat.
Changes and prognostic impact of noninvasive myocardial work indices in patients undergoing transcatheter aortic valve implantation
Authors: Ilardi Federica , Franzone Anna , Iapicca Cristina , Manzo Rachele , Angellotti Domenico , Nappa Dalila , Castiello Domenico S. , Mariani Andrea , Santoro Ciro , Avvedimento Marisa , Leone Attilio , D’Andrea Antonello , Cirillo Plinio , Spaccarotella Carmen , Piccolo Raffaele , Esposito Giovanni 
Published: October 2024

Purpose
The prognostic significance of noninvasive myocardial work (MW) indices in patients undergoing transcatheter aortic valve implantation (TAVI) has not been adequately examined.

Methods
We retrospectively selected 88 consecutive patients (mean age 79.9 ± 6.4 years, 40% males) with severe aortic stenosis scheduled for TAVI enrolled in the EffecTAVI registry. Exclusion criteria were prior valve surgery, atrial fibrillation, and left bundle branch block (LBBB) at baseline. Global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE) were measured by echocardiography at baseline and at 30 days. Accuracy of the noninvasive measures was assessed by invasive evaluation of MW.

Results
In the overall population, a significant reduction in GWI (2406 ± 567 vs. 2063 ± 515 mmHg% before and after TAVI respectively, P < 0.001), GCW (2783 ± 616 vs. 2380 ± 495 mmHg%, P < 0.001) and GWW (238 ± 203 vs. 186 ± 135 mmHg%, P = 0.015) was observed at 30 days after TAVI. GWE improved only in patients who did not develop left ventricular dyssynchrony due to new-onset LBBB or pacemaker implantation following TAVI. In a multivariable Cox-regression analysis, GWE after TAVI (hazard ratio 0.892, 95% confidence interval 0.81–0.97; P = 0.011) was the strongest predictor of adverse events (a composite of all-cause death, worsening of dyspnea, or rehospitalization for cardiovascular events) at 1-year follow-up.

Conclusions
TAVI results in significant changes in MW indices, including an early decrease in GWI, GCW and GWW, and an improvement in GWE in patients without left ventricle dyssynchrony. A GWE equal or less than 92% at 30 days is indicative of poor clinical outcomes at 1 year.
Wettbewerbsfähigkeit der Industrie und Energiepreise
Authors: Hölzl Werner , Streicher Gerhard 
Published: October 2024

Abstract
The rise in energy prices in 2021/22 put the competitiveness of Austrian manufacturing industry to the test. Model-based simulations and an enterprise survey were carried out to analyze the medium-term effects of high energy prices. The results show that the cost disadvantages in international competition induced by energy price increases will lead to a decline in industrial production and employment in the medium term and increase the risk of relocation of energy-intensive production.
Die neue Geoökonomik und ihre Auswirkungen auf den Wirtschaftsstandort
Authors: Felbermayr Gabriel 
Published: October 2024

Abstract
Geopolitical rivalries create mistrust between trading partners. These try to guard themselves against the opportunistic abuse of trade policy by de-risking and de-coupling. Indeed, first empirical evidence points towards an increasing division of the world economy into an US-centered and a China-centered block. Western sanctions against Russia have strongly accel-erated this tendency. Increased fragmentation disincentivizes corporate strategies based on serving foreign markets by exports and favors local-for-local models. This endangers value-added creation in small, open economies such as Austria. Countermeasures must include deepening the European Single Market, striking trade agreements with aligned and neutral countries, and promoting cost efficiency of European production.
Evaluation of User Satisfaction with Mobile Telephony in the State of Goiás Through Structural Equation Modeling
Authors: Oliveira Juliane de Sousa , Santos Neto Agenor Sousa , Paiva Cleyson Santos de , Soares Julio Cesar Valandro 
Published: October 2024

Objective: This study aims to investigate the satisfaction of post-paid mobile phone users in the State of Goiás, analyzing the interrelationships between perceived quality, perceived value, and consumer expectations.

Theoretical Framework: The study addresses fundamental concepts related to customer satisfaction, perceived quality, and the relevance of expectations in the service sector. It emphasizes the need for operators to understand the main factors influencing the perception of quality, taking into account regional variations in consumer preferences.

Method: The research employed Structural Equation Modeling (SEM) to analyze data obtained from the Anatel satisfaction survey of 2021, involving 172 respondents. The reliability of the questionnaire was validated through Cronbach's alpha coefficient.

Results and Discussion: The results indicated that perceived quality does not have a direct and significant effect on the overall satisfaction of users. In contrast, both perceived value and expectations showed significant relationships with satisfaction. This suggests that operators should prioritize clarity in information and agility in service to enhance the customer experience.

Research Implications: The implications highlight the necessity for operators to adjust their practices to more effectively meet the specific demands of consumers, promoting greater transparency and efficiency in the services offered.

Originality/Value: This study contributes to the understanding of the factors influencing customer satisfaction in the telecommunications sector, highlighting the importance of managing expectations. Additionally, it suggests directions for future research, including the application of statistical methodologies and artificial intelligence approaches to deepen the analysis of variables related to customer satisfaction.
Perfil de recém-nascidos em Unidade de Terapia Intensiva Neonatal durante a pandemia pela COVID-19
Authors: Santos Fernanda Pereira dos , Bortoloci Jhennifer Galassi , Costa Sara Eleotério , Mazzei Pedro Henrique Fabrício , Goldoni Esdra Cristina Pereira , Radovanovic Cremilde Aparecida Trindade , Santos Juliana Rodrigues dos , Santos Núbia Fernanda Maniero dos , Ichisato Sueli Mutsumi Tsukuda , Uema Roberta Tognollo Borotta 
Published: October 2024

Objetivo: Descrever o perfil epidemiológico de recém-nascidos internados em unidade de terapia intensiva neonatal durante pandemia pela Covid-19. Métodos: Estudo quantitativo, descritivo, exploratório e retrospectivo. Os dados foram coletados por meio de buscas em prontuários de recém-nascidos hospitalizados utilizando um instrumento estruturado no período de junho a dezembro de 2022. A análise estatística foi realizada com auxílio do software SPSS e os resultados foram apresentados em tabelas. Resultados: Foram analisados 192 prontuários de recém-nascidos hospitalizados. Observou-se que 70,7% dos recém-nascidos nasceram de cesariana, eram do sexo masculino, com peso superior a 2500g, diagnóstico de desconforto respiratório precoce e necessitando de suporte ventilatório. 93,75% das mães dos bebês realizaram pré-natal e os dados referentes tanto à infecção pelo coronavírus como à vacinação contra Covid-19 estavam ausentes. Conclusão: Foi possível descrever o perfil epidemiológico dos pacientes internados em uma unidade de terapia intensiva neonatal no período determinado foi majoritariamente composto por bebês do sexo masculino, nascidos de cesariana e que necessitaram de suporte ventilatório após o nascimento.
Including Information-Physical Quantities of Personality Traits into the International System of Units (SI)
Authors: В.А. Минкин 
Published: October 2024

Предложен подход к измерению характеристик личности, аналогичный измерению физических величин метрической системы измерения, лежащей в основе Международной системы единиц СИ. Проведен анализ открытой базы данных психофизиологической реакции (ПФР) 500 испытуемых на 48 многофакторных стимулов, имеющих привязку к способностям и порокам личности и последовательно предъявляемых программой Профайлер+. Рассмотрены различные формулы расчета текущего психофизиологического состояния (ПФС) и ПФР по данным микровибраций головы человека, измеряемым технологией виброизображения. Предложены математические критерии оценки корректности вычисления ПФС и ПФР на основании близости плотности ПФР к нормальному распределению и максимальной корреляции между ПФР на стимулы, имеющие привязку к способностям и порокам личности. По результатам анализа ПФР предложено введение в систему СИ новых информационно-физических величин и единиц измерений — бит и вибра, используемых для измерения характеристик личности. Даны определения новым единицам измерения характеристик личности, основанные на совмещении принципов психологии, кибернетики и физики в рамках единого метрологического подхода к человеку как биологическому, кибернетическому и физическому объекту.
Metrology approach to the personality characteristics is proposed, similar to the measurement of physical quantities of the International system of units (SI). The analysis was made of the open psychophysiological responses (PPR) database of 500 subjects to 48 multifactor stimuli tied to multiple intelligences and personality vices consistently presented by Blitz Judgment program. Various equations for calculating of the current psychophysiological state (PPS) and PPR according to microvibration data of a human head, measured by vibraimage technology, are considered. Mathematical criteria are proposed for assessing the correctness of PPS and PPR calculating based on the closeness of PPR distribution to the normal distribution and the maximum correlation between PPR for stimuli that are sense tied to multiple intelligences and personality vices. Based on the results of PPR analysis, it is proposed to include into the SI new values and units — the bit and the vibra used to measure personality traits. Definitions are given for new units of personality traits measurement, based on principles combination of psychology, cybernetics and physics within the framework of the single metrological approach to a person as biological, cybernetics and physical object.
Head Microvibration Characteristics Modeling and Creating Measurement Standard of Psychophysiological Response to Stimuli
Authors: В.А. Акимов , В.А. Минкин 
Published: October 2024

Исследовано влияние отдельных процессов микровибрации объекта, в том числе движения по горизонтали, вертикали, угла отклонения и контраста на параметры виброизображения объекта. Созданы несколько искусственных контрастных объектов для исследования вибраций и проанализировано влияние оптических и вибрационных характеристик объектов на параметры виброизображения. Определены основные закономерности наложения моделируемых процессов микровибрации объектов и их влияние на параметры виброизображения. Разработаны варианты эталона психофизиологической реакции на периодические стимулы в виде видеофайла и аппаратно-программного решения измерительной системы, моделирующие единицу психофизиологической реакции микровибраций головы человека — 1 вибра с неопределенностью измерений 4 мвбр. Разработан режим моделирования отдельных процессов вибраций и их наложений, приведенный в установках по умолчанию Standard в программе Vibraimage PRO.
The influence of an object microvibration processes, including horizontal, vertical movement, deflection angle and contrast, on the parameters of the object’s vibraimage was studied. Several artificial contrast objects were created to study vibration process and the influence of the optical and vibration characteristics of objects on vibraimage parameters was analyzed. The main patterns of various components of object microvibration superposition tied on vibraimage parameters are determined. Variants of the measurement standard (etalon) have been developed in the form of the video file and the hardware/software solution of measuring system that simulate the psychophysiological response to stimuli by human head microvibration. Unit of psychophysiological response to stimuli 1 vibra measurement standard with an associated standard measurement uncertainty of 4 mvbr was created. The mode for microvibration processes and their overlaps modeling has been developed in the default Standard settings of Vibraimage PRO program.
FIOS QUE (SE) TECEM: DISCURSO, TRADIÇÃO E MEMÓRIA EM CONTOS POPULARES
Authors: Dos Santos Hildete Leal , Dos Santos Adelino Pereira 
Published: October 2024

Tomando por base a teoria de Propp (1984) sobre as funções exercidas por personagens nos contos populares, neste trabalho consideramos conceitos e abordagem metodológica da Análise de Discurso de linha francesa (A.D.) para discutirmos sobre representações femininas em contos populares. Analisamos fragmentos de seis contos da tradição oral do interior da Bahia, versões locais de Cinderela, compilados nos anos finais da década de 1990, em comparação com uma matriz escrita de Perrault (1985). A análise revela que embora distantes no tempo e em diferentes condições de produção, as versões locais de Cinderela conservam as mesmas funções da matriz perraultiana, reveladoras de formações discursivas que colocam a mulher em condições de submissão e dependência do homem, em busca da redenção pelo casamento. Na constituição desses sentidos, torna-se relevante o papel da memória, a perpetuar em tradição discursos que desconsideram as então atuais conquistas e reais condições de vida da mulher na sociedade.
MACHADO DE ASSIS
Authors: David Ricardo Santos 
Published: October 2024

RESUMO

O presente artigo tem como objetivo central, debater de maneira conceitual sobre a importância da obra de Machado de Assis para a literatura brasileira. De modo que foi possível concluir que o escritor foi um visionário sobre seu tempo, especialmente no debate sobre questões polêmicas à época e que permeavam suas obras. Para a literatura e formação de cultura brasileira, não há como negar a fundamental importância e participação de Machado de Assis. A justificativa para a escolha do tema consiste na expectativa de contribuir para o âmbito acadêmico. O método de pesquisa empreendido segue natureza qualitativa, com pesquisa do tipo bibliográfica.

Palavras-chave: Machado de Assis; Literatura Brasileira; Letras.