bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rare case of an aggressive polymorphous adenocarcinoma of minor salivary gland in the retro-maxilla
Authors: Saha Mehul , Kudva Adarsh , Sharma Swati , Singh Radhika 
Published: October 2024

Abstract
Polymorphous adenocarcinoma (PAC) is a low-grade malignant tumour of minor salivary glands of the oral cavity, which rarely presents with invasive features. Low metastatic and excellent survival rates are some of its favorable features. A 36-year-old woman reported with swelling, pain, and mobility of teeth in the left upper inner cheek region. Contrast enhanced computed tomography (CECT) revealed a large, lobulated, heterogenous mass in the left retro-maxillary region with a few enlarged left cervical lymph nodes (levels IB and II). After surgery, the final histopathology report gave a definitive diagnosis of PAC with certain invasive characteristics – perineural invasion, infiltration into skeletal muscle, and depth of invasion of 10 mm, which recurred in a different location 1.5 years later. A few predictable features of PAC include incidence in elderly women, asymptomatic presentation, occurrence in the posterior hard of soft palate, very low incidence of nodal or distant metastases, perineural spread, skeletal muscle infiltration, and low rates of recurrence with good survival outcomes. However, in our case, the patient appeared to present with a relatively aggressive form of PAC, considering her young age, symptomatic presentation, uncommon anatomic location in the retro-maxilla, cervical nodal metastasis, perineural and skeletal muscle infiltration, and local recurrence within a short period. Although PAC is a low-grade tumour with excellent prognosis, it may occasionally present with invasive characteristics, and early diagnosis and prompt management with strict adherence to post-operative regimens and follow-up is of prime importance to prevent any untoward outcomes.
Quantitative correlation of serum and salivary trace elements in oral squamous cell carcinoma and oral potentially malignant disorders: An institution-based biochemical analysis
Authors: Samadi Fahad M. , Sivakumar N. , Sonam Manjari , Sharma Pooja , Suhail Shaista , Ahmad Mohammad Kaleem 
Published: October 2024

Abstract

Background:
Trace elements are the important components that play a crucial role in various functions of the human body at cellular and molecular levels. Considering the role of the trace elements in precancerous and cancerous conditions, estimation of their levels in these conditions could aid in understanding the disease process and progression. The purpose of this study is to determine the alteration in salivary electrolyte concentration of oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) patients to correlate the variations with the severity and biological behaviour.

Material and Method:
A total of 70 subjects were included in this study, and they were divided into three groups: patients with OSCC (30), OPMDs (30) and apparently healthy individuals (10). An informed consent was obtained, following which blood and saliva samples were collected from the participants. Salivary and serum levels of copper, zinc, lead, cadmium, calcium and magnesium were measured and compared between the groups.

Results:
The levels of biochemical elements in both serum and saliva were in perfect correlation. The amount of all the estimated metallic ions was found to be significantly (P 0.001) increased in OSCC followed by OPMDs and normal mucosa. The levels of copper, cadmium and magnesium were gradually increased in increasing grades of OSCC (P 0.001).

Conclusion:
Salivary trace element levels could possibly have diagnostic significance in the early evaluation of OPMDs and OSCC as well. Increased levels of these elements might be used as a marker of disease progression and predictor of prognosis.
Clear cell myoepithelioma of palate: A rare case report with brief review of literature
Authors: Viswanathan Vidya , Londhe Mangesh , Gurwale Sushama , Buch Archana 
Published: October 2024

Abstract
Myoepitheliomas are very rare salivary gland neoplasms seen mainly in the major salivary glands (~40%) followed by minor salivary glands (~21%). Palatal myoepitheliomas are rare, with clear cell types being even rarer. Due to the rarity of this tumor, it lacks specific features that are diagnostic in cytology. Histopathology, along with immunohistochemistry, is needed for its confirmative diagnosis. We present a 28-year-old female with slow-growing, painless palatal swelling diagnosed as clear cell myoepithelioma on histopathology and immunohistochemistry.
Agenesis of all premolars – the first reported case
Authors: Chalakkal Paul , Pires Vernon , Ramanathan Ramya , Rangnekar Nidhi 
Published: October 2024

Abstract
The agenesis of teeth is the most common developmental anomaly in humans. Although third molars, mandibular second premolars, maxillary lateral incisors and maxillary second premolars are frequently found to be missing, the absence of all premolars has never been reported in the literature. This case report highlights the first-ever case of the complete agenesis of premolars in a 10-year-old male patient. It also discusses related definitions; commonly missing teeth and their prevalence; associated dental and skeletal features; genetic, drug-related and pathogenic etiological factors; and considerations for the future management of such cases.
QuPath for automated analysis of digital images of oral epithelial dysplasia
Authors: Belaldavar Chetan , Angadi Punnya V. , Mudenagudi Uma 
Published: October 2024

Abstract

Objectives:
Grading of oral epithelial dysplasia (OED) has been plagued with intra-observer and inter-observer variations. To overcome this subjectivity, a more objective digital image analysis is obligatory using computer-aided software. The use of open-source software like QuPath, which is a new bio-image evaluation software program, may fulfil this growing need in virtual pathology. This study used the QuPath software for automatic analysis of morphometric parameters in hematoxylin and eosin (H and E)-stained digital images of oral epithelial dysplasia.

Methodology:
150 H and E digital images of varying grades of OED captured under 40x magnification were processed using QuPath software for automatic analysis of cellular and nuclear parameters.

Results:
The parameters that showed statistical significance included nuclear hematoxylin OD, nuclear eosin OD, cellular hematoxylin OD, cellular eosin OD, cytoplasm hematoxylin OD, and cytoplasmic eosin OD (P < 0.05), while none of the other parameters showed statistically significant differences. A prediction accuracy of 76%, 74%, and 70% for mild, moderate, and severe dysplasia was obtained, respectively.

Conclusion:
The quantitative results outlined in this paper are encouraging to indicate that the use of this technique may improve the diagnostic reliability of OED. Morphometric analysis of OED using Qupath software can be fast and reproducible and can be quantitated automatically.
Hand, foot and mouth disease (HFMD): A case report
Authors: Suryawanshi Hema , Sahu Manisha , Singh Priyambada 
Published: October 2024

Abstract
Hand, foot and mouth disease (HFMD) is a viral highly contagious disease affecting mostly infants and children and occasionally adults. It has become a significant public health problem because of frequent outbreaks and rise in its incidence, severity and fatal complications in Southeast Asian countries in the last few decades. India had experienced a sudden resurgence of HFMD recently in the year 2022. The clinical course of HFMD is mainly mild and self-limiting with recovery within 1–2 weeks, but in few patient’s, severe form of infection has been reported. In this report, we present the case of a 4-year-old boy presenting with HFMD.
Modified Cajal’s trichrome stain in oral squamous cell carcinoma
Authors: Srinidhi S S Vidya , Murugesan Ambika , Balakrishnan Sekar , Ramesh Maya , Varrshana V , Jacob Mathew 
Published: October 2024

Abstract

Background:
Modified Cajal’s trichrome stain (MCTS) is a good differential stain that allows one to visibly distinguish between connective tissue and epithelial elements with different tonalities of colour.

Aim:
Our study aims to evaluate and analyse the effectiveness of oral squamous cell carcinoma (OSCC) using MCTS.

Materials and Methods:
A study was conducted retrospectively with 30 tissue blocks embedded in paraffin from cases of OSCC that have been confirmed by histopathology. Both standard haematoxylin and eosin (H&E) and MCTS were applied to each section. Then all the sections were analysed by two observers for nucleus cytoplasmic intensity, break in the basement membrane, and advancing front of the tumour, muscle, and surrounding stroma. The efficacy of the stain was assessed and was graded as 1, poor; 2, fair; and 3, good based on the staining intensity.

Statistical Analysis:
The parameters were graded for H&E and modified Cajal’s stain. The results were subjected to the Chi-square test.

Result:
The above-mentioned parameters analysed showed a uniformly significant P value of 0.001 for comparing modified Cajal’s trichrome stain to H&E stain. Measurement of the agreement was done based on Kappa statistics between two observers, and the values for each expression show that there was good agreement between the two for all the parameters.

Conclusion:
MCTS can also be used as a diagnostic aid to pathologists for better distinction of cellular components and easier identification, thereby solving difficulties in diagnosis at earlier stages.
Mutational analysis of BRAFV600E in a case of sialadenoma papilliferum of oral cavity
Authors: Jot Kiran , Sharath Reddipalli , Bhutia Ongkila , Surya Varun 
Published: October 2024

Abstract
This case report presents a rare benign salivary gland tumour called sialadenoma papilliferum. It comprises 3 to 5% of head and neck tumours and about 1% of all minor salivary gland tumours. The focus is on discussing the BRAFV600E mutation analysis and exploring its clinical implications, along with delving into the histopathological differentials. We documented a 73-year-old male, who had a white patch in the left retromolar trigone region for 6 months. The tumour was excised with a clinical diagnosis of verrucous lesion. Microscopic examination revealed exophytic hyperplastic parakeratotic stratified squamous epithelium and endophytic ductal papillary proliferation. The BRAFV600E mutation was present in the patient. Subsequent regular follow-ups were conducted, revealing no recurrence of the condition. This case underscores the pivotal role of BRAFV600E analysis as an invaluable diagnostic tool when confronted with the intricacies of intraoral salivary gland neoplasms.
A retrospective study at a tertiary care center in North India
Authors: Gupta Poonam , Srivastava Anubha , Kumar Sujit , Pandey Siddhartha , Goyal Virey Vireshwr 
Published: October 2024

BACKGROUND AND AIM:
To describe epidemiological, clinical characteristics and comorbidities among deceased patients with COVID-19.

MATERIALS AND METHODS:
Retrospective study among deceased patients with COVID-19 infection at SRN Hospital MLN Medical College a Tertiary Care Centre for COVID 19, Prayagraj (U. P) India. The study included patients who succumbed to COVID-19 between May 5, 2020 and February 8, 2021.

RESULTS:
A total of 497 patients were taken in the study. Mean age was 59.07 years with majority of them being males 350 (71%) and 147 (29%) females. The mean duration of illness was 5.9 days. The most common symptoms were breathlessness 472 (94.9%) and fever 383 (77%). Diabetes (48%) and hypertension (42%) were the most common comorbidities among the deceased. At the time of presentation, 328 (66%) patients had heart rate >100/min and 461 (92.8%) patients had respiratory rate >24/min. Mean oxygen saturation was 69%. The mean duration of hospitalisation is 4.7 days.

CONCLUSION:
Majority of the patients who contracted the illness and died due to COVID-19 were elderly, males with diabetes and hypertension. At the time of presentation, the majority had respiratory distress of acute onset. Elderly population with comorbidities are more prone to disease and have higher chances of respiratory failure and death.
Gastric fundoplication with endoscopic technique: A novel approach for gastroesophageal reflux disease treatment
Authors: Gadour Eyad , Hoff Anna Carolina 
Published: October 2024

BACKGROUND
Gastric fundoplication with endoscopic technique (GFET) is an innovative approach to managing gastroesophageal reflux disease (GERD). This minimally invasive procedure utilizes the GEN-2 Apollo endosuture device and Olympus H2T180 gastroscope to perform partial fundoplication by strategically placing Prolene 2-0 sutures at the 11, 7, 5, 1, and 3 o’clock positions around the gastroesophageal junction.
AIM
To evaluate whether GFET enhances the lower esophageal sphincter function by creating comprehensive plication to improve the barrier against reflux.
METHODS
This single-center prospective study included patients undergoing GFET. Before beginning GFET, pH metrics and subsequent manometric measurements were obtained. An analysis of variance was performed to determine statistically significant differences between quality of life (QOL) and DeMeester scores at the time of the procedure and 6 and 12 months postoperatively. Pearson’s χ 2 test was performed to identify statistically significant differences between categorical variables at the time of the procedure and 6 and 12 months postoperatively.
RESULTS
Eighteen participants were enrolled (11 males and 7 females; mean age, 35 years). More than 70% had an initial Hill grade of IIb. One adverse event was recorded after the procedure. One patient underwent valve reinforcement at 12 months. The mean QOL score was markedly higher at the time of the procedure (39.9 ± 4.0) compared to those at 6 and 12 months postoperatively (P < 0.001). Scores at 12 months were slightly higher than those at 6 months. The highest mean QOL score was observed at the time of the procedure, followed by those at 6 and 12 months postoperatively (P < 0.001). A similar trend was noted for the mean DeMeester scores (P < 0.001).
CONCLUSION
GFET is a minimally invasive alternative to traditional surgical interventions and endoscopic techniques for managing GERD. Further research is warranted to validate its long-term efficacy and effectiveness over existing treatments.
Streptococcus suis-Associated Meningitis in a Southern Region of Vietnam
Authors: Thanh Nguyen Huu , Huy Doan Thanh , Anh Vo Thi Tram , Anh Nguyen Ngoc , Uyen Nguyen Thi Thu , Hanh Nguyen Ho Hong , Phu Nguyen Hoan 
Published: October 2024

ABSTRACT.
Streptococcus suis is the most common and severe cause of meningitis in Vietnam, but the recent data about epidemiological characteristics and sequelae are still inadequate. We performed a retrospective study to describe the epidemiology, clinical characteristics, and outcomes of patients with S. suis-associated meningitis. A retrospective study was carried out by searching records from the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, between January 2016 and January 2020. All data concerning epidemiological, clinical, and subclinical characteristics and treatment results were collected and analyzed. Over the study period, 153 cases were included in this study, with 95 cases occurring in the 2016–2017 period. The median age of all patients was 52 years (range, 29–90 years), and 70.6% of patients were male. Fifty-two patients (34%) were farmers, and the Mekong Delta was the region with the highest number of cases (60.1%). The most frequent manifestation of infection was fever (151/153, 98.7%), followed by hearing loss (64/153, 41.8%), and one patient (0.7%) died. All isolates remained susceptible to ceftriaxone, penicillin, vancomycin, and levofloxacin, whereas 99.2% of isolates were resistant to tetracycline. Occupational exposure to pigs and the consumption of contaminated food have been identified as primary risk factors associated with this zoonosis, and our study found no significant changes in epidemiological factors compared with past data. The Mekong Delta continues to be the most affected region for S. suis meningitis in southern Vietnam, with S. suis serotype 2 remaining the most relevant agent.
Case Report: Streptococcus suis Human Infections among Pork Consumers in Jeju, South Korea: Zoonotic Threats
Authors: Kim Eui Tae , Heo Sang Taek , Yoo Jeong Rae , Kim Misun , Kim Tae Hyoung , Kim Young Ree 
Published: October 2024

ABSTRACT.
Streptococcus suis, a bacterium commonly found in pigs, causes infections in humans through direct contact with infected animals or consumption of contaminated pork products. Recently, a localized outbreak of S. suis infection in humans resulted in three confirmed cases. All three patients had some form of contact with pigs in their medical history. One patient worked at a pig farm, whereas the other two consumed raw pork soup at the same restaurant. The patients were diagnosed with septicemia, subdural empyema, and infectious spondylitis. Streptococcus suis was isolated from their blood. This study was conducted to investigate the clinical features of three patients with S. suis infection and perform a molecular biological analysis of the strains obtained from them. Subsequent investigations highlighted the potential sources for this rare but serious infection and provided insight into preventive measures.
Essential Foundational Education Research Methods Articles for Graduate Medical Educators: A Delphi Study
Authors: Feig Ethan , Mayersak Ryanne , Luo Christine , Cook Mackenzie R. , Sigman Lauren , Jordan Jaime , Riddell Jeff , Zuo Leila , Villamagna Angela Holly , Bonura Erin , Yarris Lalena M. 
Published: October 2024

ABSTRACT
Background Graduate medical educators interested in designing and conducting education research may seek foundational general overview articles on education research methods.
Objective We aimed to identify the most useful foundational education research methods articles for medical educators.
Methods We identified candidate articles through a 2020 Ovid MEDLINE literature search augmented by the authors’ personal files and by cross-checking references of included articles. Articles that were primarily about general education research principles were included; articles were excluded if they were not focused on medical education research methods, were published prior to the year 2000, were written in a non-English language, or had no available abstracts. We conducted a modified Delphi study with 10 participants representing a range of specialties and education research experience to find consensus about the most useful articles. We planned 3 rounds of the Delphi process, the first to eliminate any articles not deemed useful for this audience, and the second and third rounds to include articles that at least 80% of the panel deemed “most useful” to education researchers.
Results Of 25 relevant articles identified in the literature search: one was excluded in round 1, 7 met the a priori threshold of 80% agreement for inclusion in round 2, and an additional 2 met inclusion in round 3. These 9 foundational education research methods articles relevant to graduate medical educators are described, along with a capsule summary and specific use for education researchers.
Conclusions Our modified Delphi study of foundational education research methods articles identified 9 articles deemed useful for graduate medical educators who are seeking methods resources.
Modelagem e simulação CFD da ventilação natural no Edifício Evandro Sena Freire
Authors: Rocha Igor Luiz dos Santos , Lima Cleverson Alves de , Cruz Raquel Rocha , Nascimento Andrezzo Julio Dantas , Silva Carolaine da Cruz 
Published: October 2024

O edifício Evandro Freire é um complexo estudantil que depende integralmente de condicionamento de ar para garantir condições mínimas de conforto ambiental. Tal situação provocou esta pesquisa no tocante da melhoria da eficiência energética pelo aproveitamento da ventilação natural incidente, avaliando proposições para melhorar a permeabilidade predial. Iniciou-se com a avaliação do entorno, topografia, ocupação adjacente e rugosidade do terreno, para verificar o grau de turbulência gerado sobre o fluxo natural dos ventos utilizando o modelo CFD (simulação fluidodinâmica computacional) e GIS. O valor residual sobre o edifício foi utilizado para avaliar diversos sistemas prediais passivo e ativo de distribuição dos ventos. Foram avaliados os efeitos da ventilação sobre a temperatura do prédio dos diferentes sistemas nos espaços físicos do prédio e comparados e comparados com os parâmetros de ambiência.
Tradução automática de normas técnicas em modelo semântico
Authors: Souza Douglas Lopes de , Ruschel Regina Coeli 
Published: October 2024

As normas técnicas são preparadas em linguagem natural (LN) exigindo uma análise manual, propensa a erros e demandando um alto nível de capacitação para a programação dos requisitos em plataformas dedicadas à avaliação de conformidade automatizada. A consulta e interpretação otimizada às normas técnicas escritas em LN é prejudicada e incompatível com a digitalização em curso na Arquitetura, Engenharia e Construção. Desta forma, este artigo descreve um método de extração de informações baseado em regras para a tradução automática de normas técnicas da construção civil tendo sido aplicado a Norma de Desempenho (NBR 15.575). A solução classifica-se na área de Processamento de Linguagem Natural da Inteligência Artificial. O resultado compreende um algoritmo baseado em regras de extração de informações gerando um modelo semântico de representação dos requisitos da ND. O algoritmo é composto por diversas técnicas de Processamento de Linguagem Natural baseadas em padrões linguísticos do português. Foi gerado o modelo semântico da Parte 1 da ND expresso em linguagem formal, semiestruturada em Extensible Markup Language, que pode consultado de forma otimizada ou processado em aplicações relacionadas à verificação de conformidade.
Análise comparativa do desempenho de uma habitação segundo os limites da NBR 15575 e da Passive House Standard
Authors: Da Cruz Lopes Julia , De Mesquita Duarte Carolina , Meller Gabriela , Mulazzani Doleys Soares Roberta , Sartori Ziebell Clarissa , Grala da Cunha Eduardo 
Published: October 2024

O desafio contínuo na construção civil é desenvolver estratégias eficazes para projetos de edifícios que proporcionem conforto térmico aos usuários com um consumo reduzido de energia elétrica. Portanto, este estudo teve como objetivo comparar o desempenho térmico de uma residência unifamiliar localizada na Zona Bioclimática Brasileira 2, certificada pela Passive House, com o modelo de referência pré-estabelecido pela NBR 15575 e, também, com um modelo atendendo aos requisitos mínimos da norma. A análise foi realizada por meio de simulações computacionais com o software EnergyPlus. Os resultados indicaram a qualidade térmica do modelo certificado pela Passive House em comparação aos envelopes com as configurações de referência e mínima da NBR 15575 e a relevância do atendimento dos parâmetros impostos pela norma. Diante disso, como profissionais encarregados da qualidade do ar interior em edificações e conscientes da importância do desempenho térmico, é incentivado o empenho na busca por soluções que superem os padrões estabelecidos pela norma de desempenho, visando aprimorar tanto a eficiência energética quanto o conforto térmico dos usuários.