bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is there a short-term benefit from an intra-articular steroid injection in female patients with adhesive capsulitis of the shoulder treated with physiotherapy?
Authors: Kumar Krishna , Thomas Ancy , Tetsworth Kevin , Hohmann Erik 
Published: February 2017

Introduction: The purpose of this retrospective study was to investigate the possible short-term benefit of a single intra-articular corticosteroid injection in those patients treated with physiotherapy when compared to a group of patients undergoing physiotherapy only (PT only). Methods: A retrospective chart review was conducted to identify eligible patients treated over a 4-year period. All female patients between 40 years and 60 years with a confirmed clinical diagnosis of idiopathic adhesive capsulitis who completed a prescribed physiotherapy program were considered eligible. Sixty-three patients fulfilled the inclusion criteria, but 22 were excluded because of missing data in the medical record. The remaining 41 patients comprise the study cohort; an experienced musculoskeletal physiotherapist assessed these patients both at initial presentation and at 12 weeks. Twenty patients with a mean age of 55.1 years underwent PT only and 21 patients with a mean age of 52.4 years received a single intra-articular dose of 40 mg methylprednisolone followed by physiotherapy. Outcome measures included the visual analogue scale (VAS) and measurement of range of motion. Results: At final assessment (12 weeks), significant between-group differences were identified for the ‘PT only’ group for flexion ( p = 0.01) and abduction ( p = 0.008). When comparing the mean change from the initial assessment, a significant between-group difference was observed for abduction ( p = 0.03). Conclusions: The results of this study suggest that the intra-articular injection of a single dose of cortisone has no significant short-term benefit in female patients with idiopathic adhesive capsulitis managed with physiotherapy.
Is C1 lateral mass screw placement safe for the Chinese, Indians, and Malays? An analysis of 180 computed tomography scans
Authors: Lee CK , Tan TS , Chan CYW , Kwan MK 
Published: February 2017

Introduction: C1 lateral mass (C1LM) screw is a common procedure in spine surgery. However, related studies are lacking in Asia. We aim to determine the safety of C1LM screw for the Chinese, Indians, and Malays. Methods: Three-dimensional computed tomographies of 180 subjects (60 from each ethnic) were analyzed. The length and angulations of C1LM screw and the location of internal carotid artery (ICA) in relation to C1LM were assessed and classified according to the classification by Murakami et al. The incidence of ponticulus posticus (PP) was determined and the differences among the population of these three ethnics were recorded. Results: The average base length was 8.5 ± 1.4 mm. The lengths within the lateral mass were between 14.7 ± 1.6 mm and 21.7 ± 2.3 mm. The prevalence of PP was 8.3%. 55.3% (199) of ICA were located in zone 0, 38.3% (138) in zone 1-1, 6.4% (23) in zone 1-2, and none in zone 1-3 and zone 2. The average angulation from the entry point to the ICA was 8.5° ± 6.4° laterally. The mean distance of ICA from C1 anterior cortex was 3.7 ± 1.7 mm (range: 0.6∼11.3). There was no difference in distribution of ICA in zone 1 among the three population (Chinese–47%, Indians–61%, and Malays–53%; p > 0.05). Conclusions: No ICA is located medial to the entry point of C1LM screw. If bicortical purchase of C1LM screw is needed, screw protrusion of less than 3 mm or medially angulated is safe for ICA. The incidence of PP is 8.3% with higher prevalence among the Indian population.
Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia
Authors: Nakata Yuichiro , Ueda Takeshi , Nagamachi Akiko , Yamasaki Norimasa , Ikeda Ken-ichiro , Sera Yasuyuki , Takubo Keiyo , Kanai Akinori , Oda Hideaki , Sanada Masashi , Ogawa Seishi , Tsuji Kohichiro , Ebihara Yasuhiro , Wolff Linda , Honda Zen-ichiro , Suda Toshio , Inaba Toshiya , Honda Hiroaki 
Published: February 2017

Key Points
Acquired expression of CblQ367P induces sustained proliferation of myelomonocytes, multilineage dysplasia, and splenomegaly resembling CMML. Combined inhibition of PI3K and JAK2 efficiently suppressed the growth of CblQ367P-induced CMML cells.
Recent advances in Major Histocompatibility Complex (MHC) class I antigen presentation: Plastic MHC molecules and TAPBPR-mediated quality control
Authors: van Hateren Andy , Bailey Alistair , Elliott Tim 
Published: February 2017

We have known since the late 1980s that the function of classical major histocompatibility complex (MHC) class I molecules is to bind peptides and display them at the cell surface to cytotoxic T cells. Recognition by these sentinels of the immune system can lead to the destruction of the presenting cell, thus protecting the host from pathogens and cancer. Classical MHC class I molecules (MHC I hereafter) are co-dominantly expressed, polygenic, and exceptionally polymorphic and have significant sequence diversity. Thus, in most species, there are many different MHC I allotypes expressed, each with different peptide-binding specificity, which can have a dramatic effect on disease outcome.Although MHC allotypes vary in their primary sequence, they share common tertiary and quaternary structures. Here, we review the evidence that, despite this commonality, polymorphic amino acid differences between allotypes alter the ability of MHC I molecules to change shape (that is, their conformational plasticity). We discuss how the peptide loading co-factor tapasin might modify this plasticity to augment peptide loading. Lastly, we consider recent findings concerning the functions of the non-classical MHC I molecule HLA-E as well as the tapasin-related protein TAPBPR (transporter associated with antigen presentation binding protein-related), which has been shown to act as a second quality-control stage in MHC I antigen presentation.
RNF4 interacts with multiSUMOylated ETV4
Authors: Aguilar-Martinez Elisa , Guo Baoqiang , Sharrocks Andrew D. 
Published: February 2017

Protein SUMOylation represents an important regulatory event that changes the activities of numerous proteins. Recent evidence demonstrates that polySUMO chains can act as a trigger to direct the ubiquitin ligase RNF4 to substrates to cause their turnover through the ubiquitin pathway. RNF4 uses multiple SUMO interaction motifs (SIMs) to bind to these chains. However, in addition to polySUMO chains, a multimeric binding surface created by the simultaneous SUMOylation of multiple residues on a protein or complex could also provide a platform for the recruitment of multi-SIM proteins like RNF4. Here we demonstrate that multiSUMOylated ETV4 can bind to RNF4 and that a unique combination of SIMs is required for RNF4 to interact with this multiSUMOylated platform. Thus RNF4 can bind to proteins that are either polySUMOylated through a single site or multiSUMOylated on several sites and raises the possibility that such multiSIM-multiSUMO interactions might be more widespread.
Could Good Intentions Backfire? An Empirical Analysis of the Bank Deposit Insurance
Authors: Bao Weining , Ni Jian 
Published: February 2017

The recent financial crisis led to the expansion of deposit-insurance coverage in many countries. We develop a structural model of the banking market in which banks act as financial intermediaries between consumers who have funds and businesses that seek loans, and explore the implications of such policies for banks and depositors. Our results indicate the policy could erode market discipline and increase banks’ moral hazard. As a result, banks extend their lending to riskier loans than they would have in the absence of the policy. We find this policy may even harm consumers. Moreover, market competition magnifies the lack of market discipline and induces additional moral hazard for excessive risk taking. Counterfactuals indicate banks may reduce their deposit interest rates by 2.7% in a duopoly market and almost triple their risk caps under the new policy. The estimated losses of depositors’ welfare are equivalent to at least a 3.27% drop in deposit interest rates. Data are available at https://doi.org/10.1287/mksc.2016.1009 .
The Effect of Discretion on Procurement Performance
Authors: Coviello Decio , Guglielmo Andrea , Spagnolo Giancarlo 
Published: February 2017

We run a regression discontinuity design analysis to document the causal effect of increasing buyers’ discretion on procurement outcomes in a large database for public works in Italy. Works with a value above a given threshold have to be awarded through an open auction. Works below this threshold can be more easily awarded through a restricted auction, where the buyer has some discretion in terms of who (not) to invite to bid. Our main result is that discretion increases the probability that the same firm wins repeatedly, and it does not deteriorate (and may improve) the procurement outcomes we observe. The effects of discretion persist when we repeat the analysis controlling for the geographical location, corruption, social capital, and judicial efficiency in the region of the public buyers running the auctions. Data and the online appendix are available at https://doi.org/10.1287/mnsc.2016.2628 . This paper was accepted by John List, behavioral economics.
Randomized Markdowns and Online Monitoring
Authors: Moon Ken , Bimpikis Kostas , Mendelson Haim 
Published: February 2017

Online retail reduces the costs of obtaining information about a product’s price and availability and of flexibly timing a purchase. Consequently, consumers can strategically time their purchases, weighing the costs of monitoring and the risk of inventory depletion against prospectively lower prices. At the same time, firms can observe and exploit their customers’ monitoring behavior. Using a data set tracking customers of a North American specialty retail brand, we present empirical evidence that monitoring products online is associated with successfully obtaining discounts. We develop a structural model of consumers’ dynamic monitoring to find substantial heterogeneity, with consumers’ opportunity costs for an online visit ranging from $2 to $25 in inverse relation to their price elasticities. Our estimation results have important implications for retail operations. The randomized markdown policy benefits retailers by combining price commitment with the exploitation of heterogeneity in consumers’ monitoring costs. We estimate that the retailer’s profit under randomized markdowns is 81% higher than from subgame-perfect, state-contingent pricing, because the retailer need not limit its inventory to credibly limit markdowns, which permits its jointly optimal inventory stock to expand by 133%. The welfare gain from these larger inventories splits nearly equally into retailer profit and consumer surplus. We also discuss targeting customers with price promotions using their online histories and the implications of reducing consumers’ monitoring costs.The electronic companion is available at https://doi.org/10.1287/mnsc.2016.2661 .This paper was accepted by Serguei Netessine, operations management.
Association of Blood Eosinophil and Blood Neutrophil Counts with Asthma Exacerbations in the Copenhagen General Population Study
Authors: Vedel-Krogh Signe , Fallgaard Nielsen Sune , Lange Peter , Vestbo Jørgen , Nordestgaard Børge Grønne 
Published: February 2017

AbstractBACKGROUNDBlood eosinophil count is a marker of eosinophilic airway inflammation and disease severity in asthma. However, blood neutrophil count might also be associated with disease severity. We tested the hypothesis that high blood eosinophil and neutrophil counts are both associated with the risk of asthma exacerbations among individuals with asthma from the general population.METHODSFrom the Copenhagen General Population Study with 81351 participants, we included 4838 with self-reported asthma. We recorded baseline blood eosinophil and neutrophil counts, and asthma exacerbations during follow-up in 2003–2011, defined as moderate (short-course treatment of prednisolone) or severe (hospitalization).RESULTSThe multivariable-adjusted incidence rate ratios (IRRs) were 1.28 (95% CI, 1.06–1.55) for moderate exacerbations and 1.55 (1.20–2.00) for severe exacerbations for individuals with blood eosinophil counts &gt;0.29 × 109/L (highest tertile) vs individuals with blood eosinophil counts &lt;0.18 × 109/L (lowest tertile). For blood neutrophils, the multivariable-adjusted IRRs were 2.14 (1.74–2.63) for moderate exacerbations and 1.18 (0.89–1.55) for severe exacerbations for individuals with blood neutrophil counts &gt;4.85 × 109/L (highest tertile) vs individuals with blood neutrophil counts &lt;3.77 × 109/L (lowest tertile). Blood eosinophil and neutrophil counts interacted on moderate exacerbations (P = 3 × 10−4), but not on severe exacerbations.CONCLUSIONSHigh blood eosinophil counts are associated with an increased risk of both moderate and severe asthma exacerbations, while high blood neutrophil counts are associated with an increased risk of moderate, but not severe exacerbations.
Clinical Risk Factors for Infective Endocarditis in Staphylococcus aureus Bacteremia
Authors: Salvador Vincent Bryan D. , Chapagain Bikash , Joshi Astha , Brennessel Debra J. 
Published: February 2017

Crucial to the management of staphylococcal bacteremia is an accurate evaluation of associated endocarditis, which has both therapeutic and prognostic implications. Because the clinical presentation of endocarditis can be nonspecific, the judicious use of echocardiography is important in distinguishing patients at high risk of developing endocarditis. In the presence of high-risk clinical features, an early transesophageal echocardiogram is warranted without prior transthoracic echocardiography.
The purpose of this study was to investigate the clinical risk factors for staphylococcal infective endocarditis that might warrant earlier transesophageal echocardiography and to describe the incidence of endocarditis in cases of methicillin-resistant and methicillin-sensitive Staphylococcus aureus bacteremia.
A retrospective case-control study was conducted by means of chart review of 91 patients consecutively admitted to a community hospital from January 2009 through January 2013. Clinical risk factors of patients with staphylococcal bacteremia were compared with risk factors of patients who had definite diagnoses of infective endocarditis. There were 69 patients with bacteremia alone (76%) and 22 patients with endocarditis (24%), as verified by echocardiography. Univariate analysis showed that diabetes mellitus (P=0.024), the presence of an automatic implantable cardioverter-defibrillator/pacemaker (P=0.006) or a prosthetic heart valve (P=0.003), and recent hospitalization (P=0.048) were significantly associated with developing infective endocarditis in patients with S. aureus bacteremia. The incidence of methicillin-resistant and methicillin-sensitive S. aureus bacteremia was similar in the bacteremia and infective-endocarditis groups (P=0.437).
In conclusion, identified high-risk clinical factors in the presence of bacteremia can suggest infective endocarditis. Early evaluation with transesophageal echocardiography might well be warranted.
Endovascular Exclusion of Aortobronchial Fistula and Distal Anastomotic Aneurysm after Extra-Anatomic Bypass for Aortic Coarctation
Authors: Bozzani Antonio , Arici Vittorio , Rodolico Giuseppe , Brunetto Massimo Borri , Argenteri Angelo 
Published: February 2017

The treatment of choice for aortic coarctation in adults remains open surgical repair. Aortobronchial fistula is a rare but potentially fatal late sequela of surgical correction of isthmic aortic coarctation via the interposition of a graft.
The endovascular treatment of aortobronchial fistula is still under discussion because of its high risk for infection, especially if the patient has a history of cardiovascular prosthetic implantation. Patients need close monitoring, most notably those with secondary aortobronchial fistula. We discuss the case of a 65-year-old man who presented with the combined conditions, and we briefly review the relevant medical literature.
Nonfluoroscopic Imaging as Guidance for Radiofrequency Ablation of Atrioventricular Nodal Reentrant Tachycardia after Mustard Repair
Authors: Hluchy Jan , Nguyen Dinh Q. , Sobczak Henrik , Brandts Bodo 
Published: February 2017

Most tachycardias in the pulmonary venous atrium are inaccessible by direct means and require either a retrograde approach or a transseptal approach for ablation.
We present a case in which successful radiofrequency ablation of common atrioventricular nodal reentrant tachycardia was accomplished via a retrograde transaortic approach guided by nonfluoroscopic mapping with use of the NavX™ mapping system. The patient was a 49-year-old woman who at the age of 4 years had undergone Mustard repair for complete dextrotransposition of the great arteries. Three-dimensional reconstructions of the ascending aorta, right ventricle, systemic venous atrium, left ventricle, and superior vena cava–inferior vena cava baffle complex were created, and the left-sided His bundle was marked. After a failed attempt at ablation from the systemic venous side, we eliminated the atrioventricular nodal reentrant tachycardia by ablation from the pulmonary venous side.
This case is, to our knowledge, the first report of successful radiofrequency ablation of common atrioventricular nodal reentrant tachycardia after Mustard repair for this congenital cardiac malformation in which ablation was guided by 3-dimensional nonfluoroscopic imaging. This imaging technique enabled accurate anatomic location of the ablation catheters in relation to the His bundle marked from the systemic venous side.
Modified Cone Reconstruction of the Tricuspid Valve for Ebstein Anomaly as Performed in Siberia
Authors: Krivoshchekov Evgeny V. , Ackerman Jaeger P. , Yanulevich Olga S. , Sokolov Alexander A. , Ershova Nadezhda V. , Dearani Joseph A. , Cetta Frank 
Published: February 2017

The cone reconstruction technique, first described by da Silva and modified by Dearani and by others, has become the repair method of choice in patients with Ebstein anomaly of the tricuspid valve. This report details the outcome of the modified cone reconstruction technique in 6 children who underwent surgical correction of Ebstein anomaly at the Tomsk Institute of Cardiology in Siberia.
From 2012 through 2015, 4 boys and 2 girls (age range, 11 mo–12 yr) underwent surgery to correct Ebstein anomaly. All had presented with cyanosis, exertional dyspnea, fatigue, or new-onset atrial arrhythmia, and none had undergone previous cardiac surgery. All survived the operation. One patient needed tricuspid valve replacement with a bioprosthesis after early breakdown of the cone reconstruction. As of December 2016, all the patients had no symptoms, tricuspid stenosis, or arrhythmia. This series indicates that cone reconstruction—the most anatomic repair technique for the dysmorphic Ebstein tricuspid valve—can be successfully performed in pediatric heart centers with a large experience.
Connectedness Bertini Theorem via numerical equivalence
Authors: Martinelli Diletta , Naranjo Juan Carlos , Pirola Gian Pietro 
Published: February 2017

AbstractLetXbe an irreducible projective variety and letf:X→ ℙnbe a morphism. We give a new proof of the fact that the preimage of any linear variety of dimensionk≥n+ 1 -dimf(X) is connected. We show that the statement is a consequence of the Generalized Hodge Index Theorem using easy numerical arguments that hold in any characteristic. We also prove the connectedness Theorem of Fulton and Hansen as an application of our main theorem.
Dominance order on signed integer partitions
Authors: Bisi Cinzia , Chiaselotti Giampiero , Gentile Tommaso , Oliverio Paolo Antonio 
Published: February 2017

AbstractIn 1973 Brylawski introduced and studied in detail the dominance partial order on the setPar(m) of all integer partitions of a fixed positive integerm. As it is well known, the dominance order is one of the most important partial orders on the finite setPar(m). Therefore it is very natural to ask how it changes if we allow the summands of an integer partition to take also negative values. In such a case,mcan be an arbitrary integer andPar(m) becomes an infinite set. In this paperwe extend the classical dominance order in this more general case. In particular, we consider the resulting latticePar(m) as an infinite increasing union onnof a sequence of finite latticesO(m,n). The latticeO(m,n) can be considered a generalization of the Brylawski lattice. We study in detail the lattice structure ofO(m,n).
Rheb in neuronal degeneration, regeneration, and connectivity
Authors: Potheraveedu Veena Nambiar , Schöpel Miriam , Stoll Raphael , Heumann Rolf 
Published: February 2017

Abstract
The small GTPase Rheb was originally detected as an immediate early response protein whose expression was induced by NMDA-dependent synaptic activity in the brain. Rheb’s activity is highly regulated by its GTPase activating protein (GAP), the tuberous sclerosis complex protein, which stimulates the conversion from the active, GTP-loaded into the inactive, GDP-loaded conformation. Rheb has been established as an evolutionarily conserved molecular switch protein regulating cellular growth, cell volume, cell cycle, autophagy, and amino acid uptake. The subcellular localization of Rheb and its interacting proteins critically regulate its activity and function. In stem cells, constitutive activation of Rheb enhances differentiation at the expense of self-renewal partially explaining the adverse effects of deregulated Rheb in the mammalian brain. In the context of various cellular stress conditions such as oxidative stress, ER-stress, death factor signaling, and cellular aging, Rheb activation surprisingly enhances rather than prevents cellular degeneration. This review addresses cell type- and cell state-specific function(s) of Rheb and mainly focuses on neurons and their surrounding glial cells. Mechanisms will be discussed in the context of therapy that interferes with Rheb’s activity using the antibiotic rapamycin or low molecular weight compounds.
Analysis of decreasing squared-sum of Gram–Schmidt lengths for short lattice vectors
Authors: Yasuda Masaya , Yokoyama Kazuhiro , Shimoyama Takeshi , Kogure Jun , Koshiba Takeshi 
Published: February 2017

Abstract
In 2015,
Fukase and Kashiwabara proposed an efficient method to find a very short lattice vector.
Their method has been applied to solve Darmstadt shortest vector problems of dimensions 134 to 150.
Their method is based on Schnorr’s random sampling, but their preprocessing is different from others.
It aims to decrease the sum of the squared lengths of the Gram–Schmidt vectors of a lattice basis, before executing random sampling of short lattice vectors.
The effect is substantiated from their statistical analysis, and it implies that the smaller the sum becomes, the shorter sampled vectors can be. However, no guarantee is known to strictly decrease the sum.
In this paper, we study Fukase–Kashiwabara’s method in both theory and practice, and give a heuristic but practical condition that the sum is strictly decreased.
We believe that our condition would enable one to monotonically decrease the sum
and to find a very short lattice vector in fewer steps.
Green Chemistry Pedagogy
Authors: Kolopajlo Larry 
Published: February 2017

AbstractThis chapter attempts to show how the practice of chemistry teaching and learning is enriched by the incorporation of green chemistry (GC) into lectures and labs. To support this viewpoint, evidence from a wide range of published papers serve as a cogent argument that GC attracts and engages both science and nonscience students, enhances chemistry content knowledge, and improves the image of the field, while preparing the world for a sustainable future. Published pedagogy associated with green and sustainable chemistry is critically reviewed and discussed.