bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transfection of FcγRIIIa (CD16) Alone Can Be Sufficient To Enable Human αβTCR T Lymphocytes To Mediate Antibody-Dependent Cellular Cytotoxicity
Authors: Ollier Jocelyn , Vivien Régine , Vié Henri , Clémenceau Béatrice 
Published: July 2017

Abstract
To combine the immune potential of T cells and Ab therapy, we and others have previously shown that T cells transduction with a fusion receptor that binds the Fc portion of human Ig enable them to mediate Ab-dependent cellular cytotoxicity (ADCC). The fusion receptors previously described included the FcγRIIIa (CD16) receptor coupled to different chains intended to translate the signal. In this work, we questioned whether the transfection of CD16 alone into T human lymphocytes and NK cells could be sufficient for CD16 expression and function, or whether the cotransfection of a transducing chain was mandatory. Our results demonstrated that: 1) transfection of CD16 alone into a human NK cell line and primary T cells can be sufficient for CD16 expression and function; 2) cotransfection of CD3ζ or FcεRIγ increased CD16 expression; 3) yet this increased CD16 expression increased the ADCC score only for trastuzumab, not for rituximab or cetuximab; and 4) compared with that of peripheral NK cells, ADCC scores by autologous CD16-transfected T cells ranked differently according to the opsonized target cell. Together, these results showed that neither the use of a fusion receptor nor the cotransfection of a transducing chain is mandatory to transfer the ADCC function to human lymphocytes. Thus, depending on the effector/Ab/target combination considered, transfection of CD16 alone can be sufficient to enable T cells to mediate ADCC. In the context of immunotherapy, such a strategy is by nature safer than the use of a chimeric receptor, and is freely available.
Exocrine drainage of the transplanted pancreas: A review
Authors: Beal Eliza , El-Hinnawi Ashraf , Whitson Bryan , Elkhammas Elmahdi , Henry Mitchell , Black Sylvester 
Published: July 2017

Pancreas transplant is an important treatment option for insulin dependent diabetic patients as it may result in physiologic euglycemia. Improvements in surgical technique, graft preservation, immunosuppression, diagnosis and management of rejection, and management of post-transplant complications have led to improved patient survival.There are several technical variables to consider when performing a pancreas transplant. One is the type of exocrine drainage to be used. The most common types of exocrine drainage are enteric or bladder drainage. Gastric- exocrine drainage has also been recently introduced. The most commonly cited complications associated with bladder drainage include metabolic complications, urologic complications and the need for enteric conversion.Many complications related to bladder drainage can be managed non-operatively with Foley catheter drainage. For those complications that cannot be managed in this manner, enteric conversion is an option. Complications associated with enteric drainage include anastomotic leak and intra-abdominal abscess, although at rates lower than cited in the early literature on the topic. Bladder drainage of exocrine secretions and enteric drainage of exocrine secretions, or a staged procedure with bladder drainage followed by indicated or elective enteric conversion are reasonable options for drainage of the exocrine secretions of the pancreas. Gastric-exocrine drainage is a promising therapy deserving of future exploration.
Renin angiotensin aldosterone system in the cardiovascular continuum: An overview of the trial evidence and clinical practice
Authors: Zuberi Beyla , Aijazi Ishma , Bashier Alaaeldin , Abdelgadir Elamin , Mirza Hina , Mathew Manoj , Abuelkeir Sona 
Published: July 2017

The renin angiotensin aldosterone system (RAAS) inhibitors represent an invaluable class of drugs in the management of various stages of the cardiovascular disease continuum. Both angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have unique pharmacodynamics properties. These enable them to block the RAAS system at multiple levels. The ARBs inhibit RAAS in a mechanistically distinct fashion when compared to the ACEIs. Whereas ACEIs decrease the synthesis of angiotensin II, ARBs selectively and competitively bind to the AT1 receptors hence preventing there activation by angiotensin II. The differential effects of these two groups of drugs, resulted in them playing different roles in primary and secondary cardiovascular protection. It is suggested that ACEIs tend to be more “cardioprotective” whereas ARBs may be more “cerebral-protective”.In this review article, we will attempt to enhance understanding of the role of RAAS blockers in most appropriate selection of ACEIs and ARBs according to their attributes and the needs of the clinical situation. We will initially described the role of RAAS activation in the pathophysiology of common cardiovascular disease processes. This will be followed by a review of the major clinical trials of different ACEIs and ARBs in the primary prevention and secondary prevention of cardiovascular diseases.In conclusion, the effects of ACEIs across a wide spectrum of cardiovascular diseases remain indisputable. However, ARBs showed a superior effect to ACEIs with regard to stroke, but their efficacy in certain major clinical end points seems limited.
Serum adiponectin level in children with nephrotic syndrome in relation to right ventricular functions and metabolic profiles
Authors: Hassan Asmaa , Metwalley Kotb 
Published: July 2017

Background: Adiponectin (ADPN), a protein hormone (cytokine), is exclusively expressed on and secreted from adipocytes. It is a particularly interesting compound because it may have a protective influence on the cardiovascular system. Objective: This study was designed to evaluate serum ADPN level, right ventricular functions and metabolic profiles among children with nephrotic syndrome (NS) and asses the correlations between ADPN as a protective hormone and each of right ventricular functions and metabolic profiles. Patients and Methods: A total of 47 children (28 boys; 19 girls) with steroid-responsive nephrotic syndrome (SRNS) were studied. They included two groups: Group A: included 25 children with SRNS in relapse. Group B: included 22 children with SRNS in remission for periods ranging from 3-9 months. A control group included 28 children with matched age and sex. Methods: Serum level of ADPN was estimated by ELISA and nitric oxide (NO) by chemical detection. In addition to total cholesterol, triglycerides, high-density lipoprotein (HDL), low density lipoprotein (LDL), total protein, and albumin by Enzymatic Colorimetric kits. Also, 24-hour urine samples were collected for detection of proteinuria. Electrocardiogram (ECG) and echocardiography measuring right ventricular wall functions were done. Results: Serum levels of ADPN and NO were significantly higher in children with SRNS in relapse in comparison with children with SRNS in remission or control group. Children with SRNS in relapse showed significantly higher levels of total cholesterol, triglycerides, LDL and proteinuria while significantly lower levels of total protein, albumin and HDL as compared with SRNS in remission or control group. Echocardiographic findings revealed that a significant decrease in right ventricular ejection fraction (RVEF %) and significant increase in right ventricular end diastolic diameter (RVEDD), right ventricular peak pressure (RVPP) and pulmonary artery pressure (PAP) were found in cases with SRNS in relapse in comparison to cases with SRNS in remission and control hypertrophy in relapsed cases. Finally, in children with SRNS in relapse it was found that serum ADPN level was significantly positively correlated with each of serum NO, total cholesterol, triglycerides, LDL, proteinuria, RVEDD, RVPP and PAP, while significantly negatively correlated with serum total protein, albumin and RVEF%.
Conclusion: During relapse of SRNS, serum ADPN level is higher than its level in SRNS in remission. This higher level may represent a physiologic response to the altered metabolic profiles and right ventricular strain so as to minimize cardiovascular complications.
Estudo sobre a figurabilidade em Balzac: A desfiguração do portrait de Camille Maupin
Authors: Frattini Paula Caldas 
Published: July 2017

http://dx.doi.org/10.5007/2175-7917.2016v21n2p134Nesse artigo, a ideia corrente da leitura do descritivo em Balzac como uma “mania” estilística ou como a inscrição do mundo sensível no romance prefigurando, dessa feita, uma romance de significação coerente e coesa, é reavaliada. A intenção, aqui, é sugerir ao leitor a análise de um elemento da poética balzaquiana - a figurabilidade - seus alcances estéticos e os possíveis problemas da relação entre o romance e as questões de representação. O retrato da personagem Camille Maupin do romance Béatrix desponta, dessa forma, como uma composição figurativa problemática referente à afirmação de que nos romances balzaquianos o que impera é uma representação fiel do mundo sensível. No lugar de uma reprodução fiel, notamos uma reconfiguração do corpo sensível. Na esteira do estudo de Georges Didi- Huberman sobre a semelhança informe em George Bataille e o conceito batailliano de materialismo, propomos a leitura do corpo de Camille Maupin como a descrição de um corpo informe, priorizando a maneira como o texto ficcional balzaquiano torna a figura humana visível.
Evidências Linguístico-Culturais de resistência na literatura infantil pós-colonial: literatura surda e Ondjaki
Authors: Sampaio Sonia Maria Gomes , Pissinatti Larissa Gotti 
Published: July 2017

http://dx.doi.org/10.5007/2175-7917.2016v21n2p162Este artigo identifica as representações linguístico-culturais de resistência na narrativa Adão e Eva dos autores Lodenir Karnopp e Fabiano Rosa, da literatura surda e na obra Ynari: a menina de cinco tranças do autor angolano Ondjaki. Para tanto, usamos a abordagem comparativista trazendo as evidências de resistência nas obras a partir dos estudos pós-coloniais. Na primeira parte do artigo contextualizamos as obras e após abordamos o termo resistência a partir dos estudos pós-coloniais e, em seguida adentramos na análise das obras. A fim de delimitar os elementos de análise para comparação das obras, fizemos uso de alguns aspectos da topoanálise elencados por seu criador Gaston Bachelard e revisitados por Ozíris Borges Filho, limitando nosso estudo às evidências de resistência manifestadas na obra pelos personagens e pela ambientação criada pelos autores, identificando os valores culturais e linguísticos que são expressos nas obras. Verificamos que tanto Adão e Eva como Ynari possuem elementos textuais que evidenciam valores linguístico-culturais e os autores, fazem da literatura uma estratégia de resistência.
Comparison of Vaisala radiosondes RS41 and RS92 launched over the oceans from the Arctic to the tropics
Authors: Kawai Yoshimi , Katsumata Masaki , Oshima Kazuhiro , Hori Masatake E. , Inoue Jun 
Published: July 2017

Abstract. To assess the differences between the RS92 radiosonde and its improved counterpart, the Vaisala RS41-SGP radiosonde version with a pressure sensor, 36 twin-radiosonde launches were made over the Arctic Ocean, Bering Sea, western North Pacific Ocean, and the tropical Indian Ocean during two cruises of R/V Mirai in 2015. The biases, standard deviations, and root mean squares (rms's) of the differences between the RS41 and RS92 data over all flights and altitudes were smaller than the nominal combined uncertainties of the RS41, except that the rms of the differences of pressure above 100 exceeded 0.6 hPa. A comparison between daytime and nighttime flights in the tropics revealed that the pressure difference was systematically larger during the day than at night above an altitude of 4.5 km, suggesting that there was some effect of solar heating on the pressure measurements, but the exact reason is unclear. The agreement between the RS41 and RS92 temperature measurements was better than the combined uncertainties. However, there were some noteworthy discrepancies presumably caused by the wet-bulbing effect on the RS92 radiosonde and the stagnation of the balloon. Although the median of the relative humidity differences was only a little more than 2 % of the relative humidity at all altitudes, the relative humidity of the RS92 was much lower than that of the RS41 at altitudes of about 17 km in the tropics. This dry bias might have been caused by the incomplete solar radiation correction of the RS92, and a correction table for the daytime RS92 humidity was calculated. This study showed that the RS41 measurements were consistent with the specifications of the manufacturer in most cases over both the tropical and polar oceans. However, further studies on the causes of the discrepancies are needed.
Comparison between IRI-2012 and GPS-TEC observations over the western Black Sea
Authors: Inyurt Samed , Yildirim Omer , Mekik Cetin 
Published: July 2017

Abstract. The ionosphere is a dynamic layer which generally changes according to radiation emitted by the sun, the movement of the earth around the sun, and sunspot activity. Variations can generally be categorized as regular or irregular variations. Both types of variation have a huge effect on radio wave propagation. In this study, we have focused on the seasonal variation effect, which is one of the regular forms of variation in terms of the ionosphere. We examined the seasonal variation over the ZONG station in Turkey for the year 2014. Our analysis results and IRI-2012 present different ideas about ionospheric activity. According to our analysed results, the standard deviation reached a maximum value in April 2014. However, the maximum standard deviation obtained from IRI-2012 was seen in February 2014. Furthermore, it is clear that IRI-2012 underestimated the VTEC values when compared to our results for all the months analysed. The main source of difference between the two models is the IRI-2012 topside ionospheric representation. IRI-2012 VTEC has been produced as a result of the integration of an electron density profile within altitudinal limits of 60–2000 km. In other words, the main problem with regard to the IRI-2012 VTEC representation is not being situated in the plasmaspheric part of the ionosphere. Therefore we propose that the plasmaspheric part should be taken into account to calculate the correct TEC values in mid-latitude regions, and we note that IRI-2012 does not supply precise TEC values for use in ionospheric studies.
The iFlow modelling framework v2.4: a modular idealized process-based model for flow and transport in estuaries
Authors: Dijkstra Yoeri M. , Brouwer Ronald L. , Schuttelaars Henk M. , Schramkowski George P. 
Published: July 2017

Abstract. The iFlow modelling framework is a width-averaged model for the systematic analysis of the water motion and sediment transport processes in estuaries and tidal rivers. The distinctive solution method, a mathematical perturbation method, used in the model allows for identification of the effect of individual physical processes on the water motion and sediment transport and study of the sensitivity of these processes to model parameters. This distinction between processes provides a unique tool for interpreting and explaining hydrodynamic interactions and sediment trapping. iFlow also includes a large number of options to configure the model geometry and multiple choices of turbulence and salinity models. Additionally, the model contains auxiliary components, including one that facilitates easy and fast sensitivity studies. iFlow has a modular structure, which makes it easy to include, exclude or change individual model components, called modules. Depending on the required functionality for the application at hand, modules can be selected to construct anything from very simple quasi-linear models to rather complex models involving multiple non-linear interactions. This way, the model complexity can be adjusted to the application. Once the modules containing the required functionality are selected, the underlying model structure automatically ensures modules are called in the correct order. The model inserts iteration loops over groups of modules that are mutually dependent. iFlow also ensures a smooth coupling of modules using analytical and numerical solution methods. This way the model combines the speed and accuracy of analytical solutions with the versatility of numerical solution methods. In this paper we present the modular structure, solution method and two examples of the use of iFlow. In the examples we present two case studies, of the Yangtze and Scheldt rivers, demonstrating how iFlow facilitates the analysis of model results, the understanding of the underlying physics and the testing of parameter sensitivity. A comparison of the model results to measurements shows a good qualitative agreement. iFlow is written in Python and is available as open source code under the LGPL license.
INFLUENCES OF STYRENE BUTADIENE RUBBER AND SILICA TYPES ON PERFORMANCE OF PASSENGER CAR RADIAL TIRE TREAD
Authors: Thaptong Puchong , Sae-oui Pongdhorn , Sirisinha Chakrit 
Published: July 2017

ABSTRACTA performance comparison among three types of styrene butadiene rubber (SBR), that is, emulsion polymerized SBR (ESBR), solution polymerized SBR (SSBR), and functionalized solution polymerized SBR (F-SSBR), was of interest. Effect of silica type, that is, highly dispersible silica and conventional precipitated silica, was also investigated. It is found that SSBR demonstrates significantly better heat build-up, dynamic set, abrasion resistance, including wet grip (WG) with comparable fuel efficiency, as compared to ESBR. As expected, the best tire performance, that is, abrasion resistance, WG, and fuel efficiency, is found in F-SSBR vulcanizates, attributed mainly to the greatest improvement in magnitude of rubber–filler interaction and degree of filler dispersion. Results reveal that the reactive functional group, that is, propylaminedimethoxysilane, which is chemically anchored at chain ends of F-SSBR, plays a crucial role in tire performance. Unexpectedly, silica type does not significantly influence the degree of filler dispersion, including WG and fuel saving efficiency. Probably, the predominance of sufficiently long mixing time during the compound preparation step may be responsible, as compared to the effect of silica characteristics.
MiR-411 Functions as a Tumor Suppressor in Renal Cell Cancer
Authors: Zhang Xintao , Zhang Meng , Cheng Jianli , Lv Zhaojie , Wang Feng , Cai Zhiming 
Published: July 2017

Background Recent studies have revealed that microRNAs (miRNAs) play important roles as oncogenes or tumor suppressors in tumorigenesis and tumor development, by negatively regulating protein expression. A previous study of microarrays identified that miR-411 was down-regulated in renal cell carcinoma (RCC), while few studies investigating the role of miR-411 in the pathogenesis of RCC have been performed. Methods We assessed the miR-411 expression in RCC and paired adjacent normal tissues, as well as in RCC cell lines and a normal renal cell line, by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Furthermore, the effects of miR-411 on RCC and normal renal cell proliferation, apoptosis and migration were determined using MTT assay, CCK-8 assay, flow cytometry and scratch wound assay following restoration of miR-411 with synthetic mimics. Results Results of qRT-PCR indicated that the expression of miR-411 was down-regulated in RCC tissues and cell lines when compared with adjacent normal tissues and a normal renal cell line. Further, results of CCK-8, MTT, cell scratch and transwell assay showed that over-expression of miR-411 suppressed RCC cell (786-0 and ACHN) proliferation and migration. Flow cytometry assay revealed that miR-411 could induce RCC cell apoptosis. However, overexpression of miR-411 had no obvious effect on normal renal cell line 293T Conclusions To sum up, miR-411 is significantly down-regulated and plays a role as a tumor suppressor in RCC. Further studies are warranted to determine the mechanisms of miR-411 in RCC pathogenesis and define the target genes of miR-411 in RCC.
The Circle, the Maze, and the Echo: Sublunary Recurrence and Performance in Chaucer's Legend of Ariadne
Authors: Harlan-Haughey Sarah 
Published: July 2017

Abstract
This article argues that Chaucer's tragic works explore the nightmare of the cyclical, and that an analysis of the Legend of Ariadne as a defining text at the center of Chaucer's writing career reveals his careful repetition of emotionally and philosophically charged images. The Legend of Ariadne provides a key to understanding Chaucer's conception of the Legend of Good Women as a series of echoing narratives, bound together by a series of curated repeating motifs. His condensed and crystallized deployment of classic Chaucerian themes such as the circle, the maze, and the echo gives us a sharp sense of Chaucer's tragic reading of history. To Chaucer, this doomed world is paradoxically always the same in its repetition, and constantly changing: generations die only to be replaced by others who will make the same mistakes.
DINÂMICA DA BIOMASSA E CARBONO ARBÓREO ENTRE 1995-2012 EM FLORESTA OMBRÓFILA MISTA MONTANA
Authors: Lipinski Evelyn Takahashi , Dalla Corte Ana Paula , Sanquetta Carlos Roberto , Rodrigues Aurélio Lourenço , Mognon Francelo , Behling Alexandre 
Published: July 2017

Avaliou-se a dinâmica da biomassa e do carbono no componente arbóreo acima do solo em um fragmento de Floresta Ombrófila Mista Montana no sul do Brasil. Os dados foram coletados em quatro parcelas permanentes instaladas no ano de 1995 com medições anuais até o ano de 2012. Indivíduos arbóreos com diâmetro à altura do peito (DAP) ≥10 cm foram mensurados. As árvores mortas e os indivíduos recrutas foram registrados em cada avaliação. Estimou-se a biomassa e o carbono orgânico ao nível de família, espécie e classe diamétrica. O estoque de biomassa acima do solo em árvores vivas foi estimado em 174,5 Mg ha-1 no ano de 1995 e de 235,4 Mg ha-1 para o ano de 2012, correspondendo a 73,14 Mg ha-1 e 98,66 Mg ha-1 de carbono, respectivamente. O incremento periódico anual (IPA) foi de 3,58 Mg ha-1 ano-1 de biomassa e 1,49 Mg ha-1ano-1 de carbono. O grupo das Araucárias apresentou maior estoque tanto em biomassa quanto em carbono. Entre as famílias, destacaram-se Araucariaceae e Lauraceae, e entre espécies Araucaria angustifolia. Avaliando a distribuição espacial das variáveis, contatou-se que os estoques de biomassa e carbono se mostraram muito associados à presença de Araucaria angustifolia.
The American Health Care Act: Trumped wetgeving?
Authors: Ranchordás S.H. 
Published: July 2017

The American Health Care Act: Trumped wetgeving?
De eerste bijdrage van de auteur aan de rubriek ‘Buitenlands nieuws’ had als onderwerp Obamacare (Affordable Care Act). Deze bijdrage heeft als onderwerp de opvolger ervan, vernoemd naar de opvolgende president van de Verenigde Staten: Trumpcare (American Health Care Act). Dat wil zeggen, het is onduidelijk of met de nieuwe wet Obamacare nu is afgeschaft, of slechts gewijzigd. Het oogmerk van Obamacare, namelijk het verzekeren van gelijke toegang tot de gezondsheidszorg, is daarmee weer deels ongedaan gemaakt. De American Health Care Act moet echter nog wel worden aangenomen door de Senaat. Het is de vraag of die hobbel kan worden genomen.