bluuebunny/crossref_metadata_2025_split huggingface dataset:
Better Than the Best Polar Solvent: Tuning the Polarity of 1,2,4‐ Triazolium‐Based Ionic Liquids
Authors: Singh Dharmendra , Sharma Gyanendra , Gardas Ramesh L. 
Published: May 2017

AbstractIn search of better replacement for highly polar volatile organic solvents, ionic liquids (ILs) with high polarity and high polarizability were synthesized using N‐1 substituted 1,2,4‐triazolium‐based cation with trifluoromethanesulfonate as the counter anion. The temperature dependence polarity of the synthesized ILs has been investigated using solvatochromic dyes and expressed in terms of and Kamlet‐Taft parameters (dipolarity/polarizability (π*), hydrogen bond donor acidity (α), and hydrogen bond basicity (β) in the range of (293.15−353.15) K. The introduction of the –SO3H functional group and triazole ring on the cation has revealed high polarity (
>1.2) and high polarizability (π*> 3.2). Furthermore, to understand the extent of intermolecular interaction temperature dependence refractive indices have been measured in the temperature range (293.15−343.15) K and a positive correlation was observed with polarity parameter. Finally, the impact of structure variants in terms of the N‐1 functionalized 1,2,4‐triazole ring has been analyzed over the studied properties which is scrutinized to understand the solvation capability and intermolecular interaction in ILs.
1, 2‐Epoxy Propane Induced Self‐Assembly of Macroscopic Graphene with Good Adsorption
Authors: Gao Bingying , He He , Lu Shaoxiang , Kalulu Mulenga , Oderinde Olayinka , Ren Lili 
Published: May 2017

AbstractA universal and simple one‐step approach to fabricate three‐dimensional (3D) graphene materials with the aid of 1, 2‐epoxy propane (PO) has been reported in this paper. PO, as one of widely used engineering materials, is easy to produce ring‐opening reaction under acidic conditions. When PO is introduced into graphene oxide (GO) dispersion (pH=2.4‐3.8), a 3D graphene architecture will be formed through the reaction of PO with oxygen‐containing functional groups (i. e. epoxy, carbonyl and carboxyl groups) on the surface of GO sheets. The obtained 3D graphene monolithic exhibits high porosity, strong mechanical performance, and good adsorption capacities for oil and organic dyes, which may find potential applications in wastewater treatment, environmental remediation, and electrochemistry.
Facile Access to Amino Acid Substituted Indenoisoquinolines through Carbonylative Cycloamination with [Fe(CO)5]
Authors: Slatkovská Beáta , Ondriaš Jakub , Doháňošová Jana , Gracza Tibor , Babjak Matej 
Published: May 2017

AbstractShort and facile access to indenoisoquinolines derived from amines, amino acids and a dipeptide is reported, combining modified Dieckmann condensation of phthalides with o‐bromobenzaldehydes and [Fe(CO)5] based Heck‐type carbonylation. The carbonylative step for amino acids was optimized to diminish the racemization.
A Novel Synthesis of Aryl‐ and Heteroaryl ‐ Annulated Carbazoles: Newly Synthesized Pyrido‐, Benzo[a]‐ and Spirooxindolinebenzo[a]‐carbazols
Authors: Murali Karunanidhi , Sparkes Hazel A. , Prasad Karnam Jayarampillai Rajendra 
Published: May 2017

AbstractA previously unknown class of highly substituted aryl‐ and heteroaryl‐annulated carbazoles such as pyrido[2,3‐a]carbazole, benzo[a]carbazole and spiro[indoline‐3′,4‐benzo[a]carbazole] has been prepared by the condensation of substituted α,α‐dicyanoalkenes and malononitrile with salicylaldehyde, aryl/heteroaryl aldehydes and isatin respectively in good to excellent yield. The structures of the compounds were confirmed spectroscopically (FT‐IR, 1H NMR, 13C NMR) and by single X‐ray diffraction. The generality and functional tolerance of this convergent method is demonstrated. Compared with the former and contemporary reaction methodologies, these approaches afford several advantages such as operational simplicity, simple work‐up procedure, higher yield, short reaction time and environment friendly protocols.
Effect of Narrow Oxirane Adduct Distribution on the Adsorption of Disodium Alcohol Ethoxylates Sulfosuccinate at Air–Aqueous Solution Interface
Authors: Wen Pengpeng , Gao Yuyang , Sun Yongqiang 
Published: May 2017

AbstractAdsorption behaviors at the air–water interface were presented for disodium alcohol ethoxylate sulfosuccinates (AESS) with narrow and broad oxirane adduct distribution. The CMC and equilibrium surface tension γeq of broad‐range distributed (BRD) and narrow‐range distributed (NRD) AESS2 (with average degrees of ethoxylation of 2) were measured by the Wilhelmy plate method, while the adsorption and thermodynamic parameters were calculated. The effect of temperature and inorganic electrolyte on adsorption behaviors of these two surfactants was also investigated. The results show that NRD AESS2 displays a lower CMC and higher γeq compared with BRD AESS2. At the same time, the maximum surface excess concentration Γmax of NRD AESS2 was lower than that of BRD AESS2 because of its larger steric hindrance, leading to the different adsorption and thermodynamic parameters. The adsorption of NRD AESS2 and BRD AESS2 was weakened with increasing temperature and enhanced in the presence of inorganic electrolyte.
Life‐threatening arrhythmias leading to syncope in patients with vasospastic angina
Authors: Nishizaki Mitsuhiro 
Published: May 2017

AbstractThe coronary artery diseases (CAD) that can lead to the occurrence of a syncopal attack include acute coronary syndrome, vasospastic angina, effort angina, and prior myocardial infarction. The possible mechanisms considered to lead to syncope in patients with CAD are pump failure, tachyarrhythmia, bradycardia, and vagal stimulation. Coronary artery spasm, in particular, is occasionally observed in patients with unexplained syncope in Japan. Life‐threatening arrhythmias are among the most serious complications of an ischemic attack caused by coronary spasm, and are associated with an increased risk of syncope and/or sudden cardiac death (SCD). Therefore, during the initial evaluation of unexplained syncope, the diagnosis of vasospastic angina (VSA) needs to be made promptly, to avert the risk of SCD as a consequence of syncope triggered by the lethal arrhythmia. The inducibility of polymorphic ventricular tachycardia or ventricular fibrillation, increased QT dispersion, T‐wave alternans, and early repolarization during the asymptomatic period are considered risk markers for ventricular arrhythmias during coronary spasm. In view of the conclusions from several studies, implantable cardioverter/defibrillator therapy should be considered in patients who are at high risk for recurrence of syncope due to a fatal ventricular arrhythmia triggered by coronary spasm, despite appropriate medical therapy.
Investigating Clinically and Scientifically Useful Cut Points on the Compulsive Sexual Behavior Inventory
Authors: Miner Michael H. , Raymond Nancy , Coleman Eli , Swinburne Romine Rebecca 
Published: May 2017

Abstract

Introduction
One of the major obstacles to conducting epidemiologic research and determining the incidence and prevalence of compulsive sexual behavior (CSB) has been the lack of relevant empirically derived cut points on the various instruments that have been used to measure the concept.

Aim
To further develop the Compulsive Sexual Behavior Inventory (CSBI) through exploring predictive validity and developing an empirically determined and clinically useful cut point for defining CSB.

Methods
A sample of 242 men who have sex with men was recruited from various sites in a moderate-size Midwestern city. Participants were assigned to a CSB group or a control group using an interview for the diagnosis that was patterned after the Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition. The 22-item CSBI was administered as part of a larger battery of self-report inventories.

Main Outcome Measures
Receiver operating characteristic analyses were used to compute area-under-the-curve measurements to ascertain the predictive validity of the total scale, the control subscale, and the violence subscale. Cut points were determined through consensus of experts balancing sensitivity and specificity as determined by receiver operating characteristic curves.

Results
Analyses indicated that the 22-item CSBI was a good predictor of group membership, as was the 13-item control subscale. The violence subscale added little to the predictive accuracy of the instrument; thus, it likely measures something other than CSB. Two relevant cut points were found, one that minimized false negatives and another, more conservative cut point that minimized false positives.

Conclusion
The CSBI as currently configured measures two different constructions and only the control subscale is helpful in diagnosing CSB. Therefore, we decided to eliminate the violence subscale and move forward with a 13-item scale that we have named the CSBI-13. Two cut points were developed from this revised scale, one that is useful as a clinical screening tool and the other, more conservative measurement that is useful for etiologic and epidemiologic research.
One-Stage Gender-Confirmation Surgery as a Viable Surgical Procedure for Female-to-Male Transsexuals
Authors: Stojanovic Borko , Bizic Marta , Bencic Marko , Kojovic Vladimir , Majstorovic Marko , Jeftovic Milos , Stanojevic Dusan , Djordjevic Miroslav L. 
Published: May 2017

Abstract

Background
Female-to-male gender-confirmation surgery (GCS) includes removal of breasts and female genitalia and complete genital and urethral reconstruction. With a multidisciplinary approach, these procedures can be performed in one stage, avoiding multistage operations.

Aim
To present our results of one-stage sex-reassignment surgery in female-to-male transsexuals and to emphasize the advantages of single-stage over multistage surgery.

Methods
During a period of 9 years (2007–2016), 473 patients (mean age = 31.5 years) underwent metoidioplasty. Of these, 137 (29%) underwent simultaneous hysterectomy, and 79 (16.7%) underwent one-stage GCS consisting of chest masculinization, total transvaginal hysterectomy with bilateral adnexectomy, vaginectomy, metoidioplasty, urethral lengthening, scrotoplasty, and implantation of bilateral testicular prostheses. All surgeries were performed simultaneously by teams of experienced gynecologic and gender surgeons.

Outcomes
Primary outcome measurements were surgical time, length of hospital stay, and complication and reoperation rates compared with other published data and in relation to the number of stages needed to complete GCS.

Results
Mean follow-up was 44 months (range = 10–92). Mean surgery time was 270 minutes (range = 215–325). Postoperative hospital stay was 3 to 6 days (mean = 4). Complications occurred in 20 patients (25.3%). Six patients (7.6%) had complications related to mastectomy, and one patient underwent revision surgery because of a breast hematoma. Two patients underwent conversion of transvaginal hysterectomy to an abdominal approach, and subcutaneous perineal cyst, as a consequence of colpocleisis, occurred in nine patients. There were eight complications (10%) from urethroplasty, including four fistulas, three strictures, and one diverticulum. Testicular implant rejection occurred in two patients and testicular implant displacement occurred in one patient.

Clinical Implications
Female-to-male transsexuals can undergo complete GCS, including mastectomy, hysterectomy, oophorectomy, vaginectomy, and metoidioplasty with urethral reconstruction as a one-stage procedure without increased surgical risks and complication rates.

Strengths and Limitations
To our knowledge, this is the largest cohort on this topic so far, with good surgical outcomes. Limitations include lack of selection or exclusion criteria and lack of other studies with a simple approach. For this reason, the technique should be studied further and compared with other techniques for female-to-male surgery before it can be recommended as an alternative procedure.

Conclusions
Through a multidisciplinary approach of experienced teams, one-stage GCS presents a safe, viable, and time- and cost-saving procedure. Complication rates do not differ from reported rates in multistage surgeries.
The Use of Dehydrated Human Amnion/Chorion Membrane Allograft Injection for the Treatment of Tendinopathy or Arthritis: A Case Series Involving 40 Patients
Authors: Gellhorn Alfred C. , Han Alex 
Published: May 2017

AbstractBackgroundDegenerative joint and tendon injuries remain difficult to treat, with few effective conservative treatment options available. Regenerative approaches aim to promote the inherent healing capacity of injured tissues. Micronized dehydrated human amnion/chorion membrane (dHACM) injection is an emerging regenerative option with promising preclinical results.ObjectiveTo test the clinical effectiveness of dHACM injection in patients with chronic tendinopathy and arthropathy.DesignCase series.SettingAcademic medical center outpatient sports medicine clinic.PatientsA total of 40 patients with chronic tendinosis or arthropathy who received dHACM over a period of 9 months.MethodsA structured interview was administered to patients by telephone to supplement the clinical information available in the medical chart. All patients received an ultrasound‐guided injection of dHACM.Main Outcome MeasuresThe primary outcome was change in pain level, and the secondary outcome was change in activities of daily living (ADLs) and sports/recreation function. More than 30% improvement in average pain and function was considered a successful outcome.ResultsPatient pain and function were measured at 1, 2, and 3 months after the procedure. Patient‐reported average pain scores decreased from a baseline value of 6.4 (95% confidence interval [CI] = 5.7‐7.0) to 2.7 (95% CI = 2.1‐3.3; P < .001) at 1 month, 1.7 (95% CI = 1.1‐2.2; P < .001) at 2 months, and 1.4 (95% CI = 0.9‐1.9; P < .001) at 3 months. The percentage of patients achieving clinical success, defined as 30% or greater improvement in pain levels, was 68% at 1 month, 82% at 2 months, and 91% at 3 months. Patient‐reported functional impairment in ADLs decreased from 6.8 (95% CI = 6.0‐7.5) to 2.0 (95% CI = 1.4‐2.7) (P < .001); impairment in sports/recreation decreased from 8.5 (95% CI = 7.9‐9.1) to 3.2 (95% CI = 2.6‐3.9) (P < .001). Frequency of pain medication use decreased from 29 of 40 patients (72.5%) before the procedure to 9 of 40 patients (22.5%) at final follow up (P < .001). Localized pain at the injection site was common, but no other adverse events or side effects were reported.ConclusionIn the setting of tendinosis or arthropathy, dHACM injection was clinically effective in reducing pain and improving function in a majority of adults.Level of EvidenceIV
Unpacking the role of self-reported compulsivity and impulsivity in obsessive-compulsive disorder
Authors: Prochazkova Luisa , Parkes Linden , Dawson Andrew , Youssef George , Ferreira Gabriela M. , Lorenzetti Valentina , Segrave Rebecca A. , Fontenelle Leonardo F. , Yücel Murat 
Published: May 2017

ObjectiveWe aimed to determine whether individuals with obsessive-compulsive disorder (OCD) and demographically matched healthy individuals can be clustered into distinct clinical subtypes based on dimensional measures of their self-reported compulsivity (OBQ–44 and IUS–12) and impulsivity (UPPS–P).MethodsParticipants (n=217) were 103 patients with a clinical diagnosis of OCD; 79 individuals from the community who were “OCD-likely” according to self-report (Obsessive-Compulsive Inventory–Revised scores equal or greater than 21); and 35 healthy controls. All data were collected between 2013 and 2015 using self-report measures that assessed different aspects of compulsivity and impulsivity. Principal component analysis revealed two components broadly representing an individual's level of compulsivity and impulsivity. Unsupervised clustering grouped participants into four subgroups, each representing one part of an orthogonal compulsive-impulsive phenotype.ResultsClustering converged to yield four subgroups: one group low on both compulsivity and impulsivity, comprised mostly of healthy controls and demonstrating the lowest OCD symptom severity; two groups showing roughly equal clinical severity, but with opposing drivers (i.e., high compulsivity and low impulsivity, and vice versa); and a final group high on both compulsivity and impulsivity and recording the highest clinical severity. Notably, the largest cluster of individuals with OCD was characterized by high impulsivity and low compulsivity. Our results suggest thatbothimpulsivity and compulsivity mediate obsessive-compulsive symptomatology.ConclusionsIndividuals with OCD can be clustered into distinct subtypes based on measures of compulsivity and impulsivity, with the latter being found to be one of the more defining characteristics of the disorder. These dimensions may serve as viable and novel treatment targets.
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection
Authors: Sinha Rileen , Winer Andrew G. , Chevinsky Michael , Jakubowski Christopher , Chen Ying-Bei , Dong Yiyu , Tickoo Satish K. , Reuter Victor E. , Russo Paul , Coleman Jonathan A. , Sander Chris , Hsieh James J. , Hakimi A. Ari 
Published: May 2017

AbstractThe utility of cancer cell lines is affected by the similarity to endogenous tumour cells. Here we compare genomic data from 65 kidney-derived cell lines from the Cancer Cell Line Encyclopedia and the COSMIC Cell Lines Project to three renal cancer subtypes from The Cancer Genome Atlas: clear cell renal cell carcinoma (ccRCC, also known as kidney renal clear cell carcinoma), papillary (pRCC, also known as kidney papillary) and chromophobe (chRCC, also known as kidney chromophobe) renal cell carcinoma. Clustering copy number alterations shows that most cell lines resemble ccRCC, a few (including some often used as models of ccRCC) resemble pRCC, and none resemble chRCC. Human ccRCC tumours clustering with cell lines display clinical and genomic features of more aggressive disease, suggesting that cell lines best represent aggressive tumours. We stratify mutations and copy number alterations for important kidney cancer genes by the consistency between databases, and classify cell lines into established gene expression-based indolent and aggressive subtypes. Our results could aid investigators in analysing appropriate renal cancer cell lines.
HLA-DP84Gly constitutively presents endogenous peptides generated by the class I antigen processing pathway
Authors: Yamashita Yuki , Anczurowski Mark , Nakatsugawa Munehide , Tanaka Makito , Kagoya Yuki , Sinha Ankit , Chamoto Kenji , Ochi Toshiki , Guo Tingxi , Saso Kayoko , Butler Marcus O. , Minden Mark D. , Kislinger Thomas , Hirano Naoto 
Published: May 2017

AbstractClassical antigen processing leads to the presentation of antigenic peptides derived from endogenous and exogenous sources for MHC class I and class II molecules, respectively. Here we show that, unlike other class II molecules, prevalent HLA-DP molecules with β-chains encoding Gly84 (DP84Gly) constitutively present endogenous peptides. DP84Glydoes not bind invariant chain (Ii) via the class II-associated invariant chain peptide (CLIP) region, nor does it present CLIP. However, Ii does facilitate the transport of DP84Glyfrom the endoplasmic reticulum (ER) to the endosomal/lysosomal pathway by transiently binding DP84Glyvia a non-CLIP region(s) in a pH-sensitive manner. Accordingly, like class I, DP84Glyconstitutively presents endogenous peptides processed by the proteasome and transported to the ER by the transporter associated with antigen processing (TAP). Therefore, DP84Gly, found only in common chimpanzees and humans, uniquely uses both class I and II antigen-processing pathways to present peptides derived from intracellular and extracellular sources.
New Insight into the Ground State of FePc: A Diffusion Monte Carlo Study
Authors: Ichibha Tom , Hou Zhufeng , Hongo Kenta , Maezono Ryo 
Published: May 2017

AbstractWe have applied DMC to evaluate relative stability of the possible electronic configurations of an isolated FePc under D4h
symmetry, considering some fixed nodes generated from different methods. They predict A2g
ground state consistently, supporting preceding DFT studies, with confidence overcoming the ambiguity about exchange-correlation (XC) functionals. By comparing DMC with several XC, we clarified the importance of the short-range exchange to describe the relative stability. We examined why the predicted A2g
is excluded from possible ground states in the recent ligand field based model. Simplified assumptions made in the superposition model are identified to give unreasonably less energy gain for A2g
when compared with the reality. The state is found to have possible reasons for the stabilization, reducing the occupations from an unstable anti-bonding orbital, avoiding double occupation of a spatially localized orbital, and gaining exchange energy by putting a triplet spin pair in degenerate orbitals.
Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications
Authors: Prada-Medina Cesar A. , Fukutani Kiyoshi F. , Pavan Kumar Nathella , Gil-Santana Leonardo , Babu Subash , Lichtenstein Flávio , West Kim , Sivakumar Shanmugam , Menon Pradeep A. , Viswanathan Vijay , Andrade Bruno B. , Nakaya Helder I. , Kornfeld Hardy 
Published: May 2017

AbstractComorbid diabetes mellitus (DM) increases tuberculosis (TB) risk and adverse outcomes but the pathological interactions between DM and TB remain incompletely understood. We performed an integrative analysis of whole blood gene expression and plasma analytes, comparing South Indian TB patients with and without DM to diabetic and non-diabetic controls without TB. Luminex assay of plasma cytokines and growth factors delineated a distinct biosignature in comorbid TBDM in this cohort. Transcriptional profiling revealed elements in common with published TB signatures from cohorts that excluded DM. Neutrophil count correlated with the molecular degree of perturbation, especially in TBDM patients. Body mass index and HDL cholesterol were negatively correlated with molecular degree of perturbation. Diabetic complication pathways including several pathways linked to epigenetic reprogramming were activated in TBDM above levels observed with DM alone. Our data provide a rationale for trials of host-directed therapies in TBDM, targeting neutrophilic inflammation and diabetic complication pathways to address the greater morbidity and mortality associated with this increasingly prevalent dual burden of communicable and non-communicable diseases.