bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex
Authors: Khan Meraj H. , Salomaa Siiri I. , Jacquemet Guillaume , Butt Umar , Miihkinen Mitro , Deguchi Takahiro , Kremneva Elena , Lappalainen Pekka , Humphries Martin J. , Pouwels Jeroen 
Published: August 2017

ABSTRACT
Sharpin, a multifunctional adaptor protein, regulates several signalling pathways. For example, Sharpin enhances signal-induced NF-κB signalling as part of the linear ubiquitin assembly complex (LUBAC) and inhibits integrins, the T cell receptor, caspase 1 and PTEN. However, despite recent insights into Sharpin and LUBAC function, a systematic approach to identify the signalling pathways regulated by Sharpin has not been reported. Here, we present the first ‘Sharpin interactome’, which identifies a large number of novel potential Sharpin interactors in addition to several known ones. These data suggest that Sharpin and LUBAC might regulate a larger number of biological processes than previously identified, such as endosomal trafficking, RNA processing, metabolism and cytoskeleton regulation. Importantly, using the Sharpin interactome, we have identified a novel role for Sharpin in lamellipodium formation. We demonstrate that Sharpin interacts with Arp2/3, a protein complex that catalyses actin filament branching. We have identified the Arp2/3-binding site in Sharpin and demonstrate using a specific Arp2/3-binding deficient mutant that the Sharpin–Arp2/3 interaction promotes lamellipodium formation in a LUBAC-independent fashion.
This article has an associated First Person interview with the first author of the paper.
Peroxisomal plant metabolism – an update on nitric oxide, Ca2+ and the NADPH recycling network
Authors: Corpas Francisco J. , Barroso Juan B. 
Published: August 2017

ABSTRACT
Plant peroxisomes are recognized organelles that – with their capacity to generate greater amounts of H2O2 than other subcellular compartments – have a remarkable oxidative metabolism. However, over the last 15 years, new information has shown that plant peroxisomes contain other important molecules and enzymes, including nitric oxide (NO), peroxynitrite, a NADPH-recycling system, Ca2+ and lipid-derived signals, such as jasmonic acid (JA) and nitro-fatty acid (NO2-FA). This highlights the potential for complex interactions within the peroxisomal nitro-oxidative metabolism, which also affects the status of the cell and consequently its physiological processes. In this review, we provide an update on the peroxisomal interactions between all these molecules. Particular emphasis will be placed on the generation of the free-radical NO, which requires the presence of Ca2+, calmodulin and NADPH redox power. Peroxisomes possess several NADPH regeneration mechanisms, such as those mediated by glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) proteins, which are involved in the oxidative phase of the pentose phosphate pathway, as well as that mediated by NADP-isocitrate dehydrogenase (ICDH). The generated NADPH is also an essential cofactor across other peroxisomal pathways, including the antioxidant ascorbate–glutathione cycle and unsaturated fatty acid β-oxidation, the latter being a source of powerful signaling molecules such as JA and NO2-FA.
The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development
Authors: Huang Huai-Wei , Zeng Xiaomei , Rhim Taiyoun , Ron David , Ryoo Hyung Don 
Published: August 2017

ABSTRACT
IRE1 mediates the unfolded protein response (UPR) in part by regulating XBP1 mRNA splicing in response to endoplasmic reticulum (ER) stress. In cultured metazoan cells, IRE1 also exhibits XBP1-independent biochemical activities. IRE1 and XBP1 are developmentally essential genes in Drosophila and mammals, but the source of the physiological ER stress and the relative contributions of XBP1 activation versus other IRE1 functions to development remain unknown. Here, we employed Drosophila to address this question. Explicitly, we find that specific regions of the developing alimentary canal, fat body and the male reproductive organ are the sources of physiological stress that require Ire1 and Xbp1 for resolution. In particular, the developmental lethality associated with an Xbp1 null mutation was rescued by transgenic expression of Xbp1 in the alimentary canal. The domains of IRE1 that are involved in detecting unfolded proteins, cleaving RNAs and activating XBP1 splicing were all essential for development. The earlier onset of developmental defects in Ire1 mutant larvae compared to in Xbp1-null flies supports a developmental role for XBP1-independent IRE1 RNase activity, while challenging the importance of RNase-independent effector mechanisms of Drosophila IRE1 function.
Stability of a Markov-modulated Markov Chain, with Application to a Wireless Network Governed by two Protocols
Authors: Foss Sergey , Shneer Seva , Tyurlikov Andrey 
Published: August 2017

We consider a discrete-time Markov chain (Xt,Yt), t = 0, 1, 2,…, where the X-component forms a Markov chain itself. Assume that (Xt) is Harris-ergodic and consider an auxiliary Markov chain [Formula: see text] whose transition probabilities are the averages of transition probabilities of the Y-component of the (X, Y)-chain, where the averaging is weighted by the stationary distribution of the X-component.We first provide natural conditions in terms of test functions ensuring that the [Formula: see text]-chain is positive recurrent and then prove that these conditions are also sufficient for positive recurrence of the original chain (Xt, Yt). The we prove a “multi-dimensional” extension of the result obtained. In the second part of the paper, we apply our results to two versions of a multi-access wireless model governed by two randomised protocols.
On the Power of (Even a Little) Resource Pooling
Authors: Tsitsiklis John N. , Xu Kuang 
Published: August 2017

We propose and analyze a multi-server model that captures a performance trade-off between centralized and distributed processing. In our model, a fraction p of an available resource is deployed in a centralized manner (e.g., to serve a most-loaded station) while the remaining fraction 1 − p is allocated to local servers that can only serve requests addressed specifically to their respective stations. Using a fluid model approach, we demonstrate a surprising phase transition in the steady-state delay scaling, as p changes: in the limit of a large number of stations, and when any amount of centralization is available (p > 0), the average queue length in steady state scales as [Formula: see text] when the traffic intensity λ goes to 1. This is exponentially smaller than the usual M/M/1-queue delay scaling of [Formula: see text], obtained when all resources are fully allocated to local stations (p = 0). This indicates a strong qualitative impact of even a small degree of resource pooling. We prove convergence to a fluid limit, and characterize both the transient and steady-state behavior of the actual system, in the limit as the number of stations N goes to infinity. We show that the sequence of queue-length processes converges to a unique fluid trajectory (over any finite time interval, as N → ∞), and that this fluid trajectory converges to a unique invariant state vI, for which a simple closed-form expression is obtained. We also show that the steady-state distribution of the N-server system concentrates on vI as N goes to infinity.
Large Deviations of the Interference in the Ginibre Network Model
Authors: Torrisi Giovanni Luca , Leonardi Emilio 
Published: August 2017

Under different assumptions on the distribution of the fading random variables, we derive large deviation estimates for the tail of the interference in a wireless network model whose nodes are placed, over a bounded region of the plane, according to the β-Ginibre process, 0 < β ≤ 1. The family of β-Ginibre processes is formed by determinantal point processes, with different degree of repulsiveness. As β → 0, β-Ginibre processes converge in law to a homogeneous Poisson process. In this sense the Poisson network model may be considered as the limiting uncorrelated case of the β-Ginibre network model. Our results indicate the existence of two different regimes. When the fading random variables are bounded or Weibull superexponential, large values of the interference are typically originated by the sum of several equivalent interfering contributions due to nodes in the vicinity of the receiver. In this case, the tail of the interference has, on the log-scale, the same asymptotic behavior for any value of 0 < β ≤ 1, but it differs from the asymptotic behavior of the tail of the interference in the Poisson network model (again on a log-scale) [14]. When the fading random variables are exponential or subexponential, instead, large values of the interference are typically originated by a single dominating interferer node and, on the log-scale, the asymptotic behavior of the tail of the interference is insensitive to the distribution of the nodes, as long as the number of nodes is guaranteed to be light-tailed.
On Patient Flow in Hospitals: A Data-Based Queueing-Science Perspective
Authors: Armony Mor , Israelit Shlomo , Mandelbaum Avishai , Marmor Yariv N. , Tseytlin Yulia , Yom-Tov Galit B. 
Published: August 2017

Hospitals are complex systems with essential societal benefits and huge mounting costs. These costs are exacerbated by inefficiencies in hospital processes, which are often manifested by congestion and long delays in patient care. Thus, a queueing-network view of patient flow in hospitals is natural for studying and improving its performance. The goal of our research is to explore patient flow data through the lens of a queueing scientist. The means is exploratory data analysis (EDA) in a large Israeli hospital, which reveals important features that are not readily explainable by existing models. Questions raised by our EDA include: Can a simple (parsimonious) queueing model usefully capture the complex operational reality of the Emergency Department (ED)? What time scales and operational regimes are relevant for modeling patient length of stay in the Internal Wards (IWs)? How do protocols of patient transfer between the ED and the IWs influence patient delay, workload division and fairness? EDA also underscores the importance of an integrative view of hospital units by, for example, relating ED bottlenecks to IW physician protocols. The significance of such questions and our related findings raise the need for novel queueing models and theory, which we present here as research opportunities. Hospital data, and specifically patient flow data at the level of the individual patient, is increasingly collected but is typically confidential and/or proprietary. We have been fortunate to partner with a hospital that allowed us to open up its data for everyone to access. This enables reproducibility of our findings, through a user-friendly platform that is accessible via the Technion SEELab.
The technological system 2.0: Suggested amendments and revisions under digital assumptions
Authors: Schuchardt Read Mercer 
Published: August 2017

Abstract
When Jacques Ellul wrote Technological System in 1980, he understood it as an update to his earlier observations. By and large, these updates were analogous to the metastasizing of cancer cells; what Ellul saw was that there was ‘more’ technology everywhere, yet its assumptions were largely dependent on the nature of technologies he had analysed in his earlier work, The Technological Society in 1954. In this article, I update the previous insights of Ellul to take into account the critical mass of Internet and cell phone technologies. The ‘digital technological system’ has several more defining characteristics that need to be incorporated in order to fully assess and comprehend the technological system through Ellul’s original lens. By demonstrating that now too ‘that stage has passed’, this article nevertheless shows a continuity with Ellul’s thought in demonstrating that the digital technological system still contains the previous characteristics of autonomy, unity, universality and totalization but that the new digital stage also adds the characteristics of ubiquity, atemporality and disincarnation. What problems this presents for ‘man’ in the digital technological system is the key concern of the resulting analysis.
Jacques Ellul’s contributions to media literacy: Examining The Technological Bluff
Authors: Forsberg Geraldine E. 
Published: August 2017

Abstract
This article examines some of the rhetorical bluffs identified by Jacques Ellul in his book The Technological Bluff. The author explores how understanding the rhetoric about media and technology can contribute to teaching media literacy. Often the focus in education is on a critique of specific media and technologies. Ellul focuses our attention on the rhetoric about technology. This is a unique and important approach to media literacy.
Self and the city: Teaching sensory perception and integration in City as Classroom
Authors: McLeod Rogers Jaqueline 
Published: August 2017

Abstract

City as Classroom – a text McLuhan co-authored with Eric McLuhan and Kathryn Hutchon in 1977 – takes as its chief goal educating readers to identify ‘[p]atterns and structures [that] “make sense” of things’ (McLuhan et al. 1977: 165), presenting readers with a pedagogical model for exercising and attempting to balance their multiple senses. The text is directed in particular at a youthful audience, those who have inherited a technologized world but no critical tools for understanding or managing it. McLuhan invites readers to explore a process of knowing meant to reactivate human capacities turned off by a succession of takeover technologies. He reveals to readers/practitioners the power of the senses to capture rich perceptual information, engaging them in reshaping both how they know the environment and what they know of it. Offering non-mainstream pedagogical concepts and libratory learning practices and outcomes, this text speaks to the needs of contemporary students and readers.
The four ecologies, post-evolution and singularity
Authors: Zhang Peter 
Published: August 2017

Abstract
This article responds to the imminent break boundary humanity is facing from the vantage point of the productive interface between media ecology and French thought, especially that of Deleuze, Guattari and Virilio. It extends Guattari’s work by putting forward the notion of the four ecologies, reveals the post-evolutionary nature of our era and promotes spiritual singularity, as distinguished from technological singularity, as a phronētic way of pursuing the good life at this historical juncture. The article belongs to the emerging body of literature on interology. A Zen sensibility runs through the entire article.
Una educación estadística: para una sociedad que tolere la incertidumbre
Authors: Rocha Salamanca Pedro 
Published: August 2017

Este trabajo forma parte de la revisión de los antecedentes y parte de la construcción del marco conceptual de la tesis doctoral titulada “Las prácticas docentes de los profesores de estadística y probabilidad en las facultades de ingeniería”, se presenta desde la perspectiva de la cultura estadística como elemento importante cuando los ciudadanos tienen que tomar decisiones en situaciones de incertidumbre.
Historia de la Universidad Distrital: capítulo: la fundación (1948-1950)
Authors: Reina Rodríguez Carlos Arturo 
Published: August 2017

La Universidad Distrital Francisco José de Caldas cuenta con más de 60 años de existencia. Su fundación es el resultado de un proceso histórico acumulado por la experiencia de las Escuelas de Artes y Oficios y las Escuelas Industriales en el país, creadas en el siglo XIX. La necesidad de formar a los sectores pobres que no podían acceder a la educación superior fue una de las razones de su existencia. En la constitución del Colegio Municipal de Bogotá en 1948 se destacaron personajes como Antonio García Nossa, Gabriel Anzola o Jorge Eliécer Gaitán. Hacia 1850, el 6 de agosto y bajo la rectoría del presbítero Daniel de Cayzedo, fue fundada la Universidad Municipal de Bogotá Francisco José de Caldas. Esta investigación busca brindar nuevos referentes para la construcción de una historia de la Universidad Distrital y aportar elementos para la historia de la Educación Superior en Colombia.
Procesos de comunicación en la clase de matemáticas de grado 5°
Authors: Beltrán Perdomo Liceth Katherine , Caro Andrés Felipe , Fernández Herrán Diana Paola , Rozo Castañeda Lina Estefanía 
Published: August 2017

En este artículo se muestran los resultados de un proyecto de campo realizado mediante la utilización de una metodología de estudio de caso, centrado en las estrategias utilizadas en los procesos de comunicación frente a la relación estudiante-docente de la clase de matemáticas en grado quinto, a partir de la aplicación de unos instrumentos de investigación diseñados ybasándolo en lo propuesto por Camacaro (2008), Chevallard (1991), Cross (2000), Kaplun (1998), Rojas (2009) y otros, se logró evidenciar la falta de afinidad entre las opiniones de lo percibido por el docente y por el estudiante y las concepciones de superioridad que se tiene de los roles que están en juego en el aula.
El enfoque sociocultural en educación matemática desde la perspectiva de estudiantes para profesor: una aproximación inicial desde sus concepciones
Authors: Fuentes Leal Christian Camilo , Martínez Hernández Julián David 
Published: August 2017

El enfoque socio-cultual en educación matemática presenta algunos elementos que hasta hace algunos años eran invisibles o no tenían importancia en la enseñanza de las matemáticas, entre ellos la importancia del contexto, las interacciones sociales en el aula de clase y los aportes de espacios extra escolares a la escuela, en el presente documento se muestra una aproximación inicial sobre algunas concepciones de un grupo de estudiantes para profesor de la licenciatura en educación básica con énfasis en matemáticas de la universidad distrital (LEBEM), por medio de una aplicación de una encuesta tipo Likert, el análisis pretenderá buscar algunas interpretaciones y comprensiones sobre las respuestas propuestas por los estudiantes.
La modelación matemática en la ingeniería de dieseño
Authors: Rendón Mesa Paula Andrea , Duarte Pedro Vicente Esteban , Villa Ochoa Jhony Alexander 
Published: August 2017

Se pretende, en esta comunicación, informar algunos aspectos que se vienen adelantando en una investigación correspondiente a la formación del Doctorado en Educación de la Universidad de Antioquia. Se pretende discutir cómo la Modelación Matemática se puede convertir en una herramienta de formación para los ingenieros, propiamente en Ingeniería de Diseño. Se describe la forma cómo se realiza el trabajo en el transcurso del semestre y se ejemplifica dando a conocer avances de los resultados obtenidos. Finalmente, se plantea la necesidad de pensar la Modelación Matemática, como una alternativa donde el estudiante construya una “realidad” y responda a las exigencias actuales de tener un saber específico aplicado a un contexto, generando una articulación entre el saber matemático y el saber propio de la Ingeniería de Diseño.
Análisis del uso del razonamiento Bayesiano en estudiantes de básica primaria
Authors: Torres Mondragón Karen Yissed , Parra López Ginneth Viviana 
Published: August 2017

Diversas investigaciones sobre la enseñanza de la probabilidad han podido determinar que para las personas es difícil contar hechos en los cuales se privilegie la incertidumbre y a su vez incentive la capacidad para interpretar, comunicar y evaluar situaciones probabilísticas; esto ocurre porque la población está educada bajo la lógica determinista, la cual consiste en que el individuo siempre espere un mismo resultado, y este sea predecible, o bivalente; es decir, que corresponde a responder con un sí o un no. Se presenta un trabajo que centró la mirada en el análisis del razonamiento Bayesiano no como el hecho de utilizar algoritmos, sino como el tomar decisiones en situaciones de incertidumbre para estudiantes de básica primaria.
Análisis del concepto de función en estudiantes sordos de grado décimo
Authors: Peña Giraldo Raúl , Aldana Bermúdez Eliécer 
Published: August 2017

Este estudio de caso hace parte de una investigación que se está realizando con estudiantes sordos de grados octavo y décimo, con el propósito de lograr la comprensión/construcción del concepto de función, desde las dimensiones epistemológicas, didáctica y cognitiva. El estudio se undamenta en el marco teórico de los registros de representación semiótica y la metodología de la Ingeniería didáctica, apoyado en el diseño, desarrollo e implementaciónde un software.
La actividad de aprendizaje de matemáticas en ingeniería de alimentos: constitución del sentido personal del estudiante
Authors: Villada Ramírez Rigoberto 
Published: August 2017

Este escrito es un proyecto de investigación de Maestría en Educación Matemática. El objetivo que orienta dicha investigación es analizar el proceso de constitución del sentido personal de los estudiantes de ingeniería de alimentos desde y hacia la actividad de aprendizaje de matemáticas. La aproximación teórico-metodológica se fundamenta en las contribuciones de la perspectiva histórico-cultural de la educación y de la Teoría de la Actividad. Dicha aproximación se basa una metodología enmarcada en una investigación colaborativa, el grupo colaborativo está conformado por el investigador, el profesor del curso y algunos estudiantes. Los registros y datos se producen por los estudiantes y el investigador a partir de diarios de campo, autobiografías, análisis de episodios, ideogramas, textos escritos, mapas conceptuales y entrevistas.
MatemaTIC. Una experiencia de aula que integra las matemáticas y las TIC
Authors: Pérez Franklin Eduardo , Gómez Juan Diego 
Published: August 2017

En este texto se presenta una experiencia de aula desarrollada con un grupo aproximado de 170 estudiantes del grado décimo del Instituto San Carlos (ISC). En el 2012 se propuso la apertura de un blog en la web, constituido por cuatro diferentes productos asociados a cuatro fases.
Perspectivas para formar profesores de matemáticas: disminuyendo la brecha entre la teoría y la práctica-Prospects for training teachers of mathematics: brinding the breach between theory and practice
Authors: Parada-Rico Sandra Evely , Fiallo-Leal Jorge Enrique 
Published: August 2017

En este artículo se analizan algunas acepciones sobre la problemática de la formación inicial y continuada de profesores de matemáticas. Se plantea la necesidad de posibilitar experiencias y espacios de aprendizaje en los programas de formación y de actualización de docentes, en los que se reflexione sobre las prácticas del aula y problemáticas educativas reales, esto con el fin de disminuir la brecha entre las teorías y las prácticas profesionales. A partir de resultados de investigación se proponen alternativas de formación como: 1) en la formación inicial las tutorías académicas universitarias como práctica docente pueden aportar en el desarrollo del pensamiento reflexivo de los futuros maestros; así mismo, la vinculación de estos en investigaciones los puede proyectar como educadores matemáticos, y 2) para el desarrollo profesional, se plantea la necesidad de construir espacios de trabajo colaborativo como puede ser al interior de comunidades de práctica.