bluuebunny/crossref_metadata_2025_split huggingface dataset:
The formation of new inter-firm relationships: a UK offshore wind sector analysis
Authors: Hennelly Patrick , Wong Chee Yew 
Published: May 2016

PurposeThe focus of this paper is to understand the initial formation of inter-firm relationship with the ultimate aim to form a long-term relationship in offshore-wind sector. The research question is “How and why new inter-firm relationships are built in nascent industries with highly uncertain business environments?”Design/methodology/approachLongitudinal case studies of three pairs of new inter-firm relationships based on interviews and other archival data are analysed.FindingsNot all new inter-firm relationships progressed to expansion stage, largely owing to incompatibility and uncertainty. In some cases incompatibility could be rectified by trust and sharing of information. High trust is required to move the relationship from awareness to exploration stage. Investment in R&D is required to move the relationship from exploration to expansion. Innovation complementarity is the key in OSW sector.Practical implicationsProvide insights into how new inter-firm relationships in OSW sector could fail or be built up. High trust at the beginning helps to lower risk and encourages further investment.Originality/valueInform inter-firm relationship theories under high market risk and political uncertainty, especially for OSW sector.
Characterization of metals in air and soil near a steel making plant in the North part of Italy
Authors: Rada Elena C. , Ragazzi Marco , Tubino Marco , Gambaro Andrea , Turetta Clara , Argiriadis Elena , Vecchiato Marco , Rossi Barbara , Tava Maurizio 
Published: May 2016

Purpose
– The purpose of this paper is to define suitable tracers that are particularly significant in assessing the impact on the surrounding environment caused by a steel making plant.

Design/methodology/approach
– The authors focussed on the detection and quantification of inorganic pollutants such as heavy metals in the soil and in the air in the surrounding area of the steel making plant. The presented data, concerning a plant in the North part of Italy, come from an approach that took into account the advantages of different devices and sampling criteria: apart from conventional devices, two kinds of deposimeters have been used (for characterizing either total or wet/dry depositions). Their locations have been chosen taking into account the distance from the plant.

Findings
– The paper demonstrates that the presence of diffused emissions plays an important (negative) role still today; thus a modern plant should reduce this kind of emission in order to be accepted from the population living in the surroundings. In the analyzed case study, the benefits of adopting the best available technologies can be seen from the temporal variability of the incidence of the plant.

Originality/value
– The value of the paper is in the support that it can give to decision makers that must manage a steel making plant in an area.
Effect of irregularity and anisotropy on the dynamic response due to a shear load moving on an irregular orthotropic half-space under influence of gravity
Authors: Singh Abhishek K. , Lakshman Anirban , Chattopadhyay Amares 
Published: May 2016

Purpose– The response of moving load over a surface is a subject of investigation because of its possible applications in determining the strength of a structure. Recently, with the enlargement of high-speed train networks, concern has been expressed about the effects of moving loads on the track, embankment and nearby structures. Earth surface and artificial structure are not always regular in nature. Irregularities are also responsible for structural collapse of long bridge and highway of plateau area under the action of moving loads. The purpose of this paper is to investigate the influence of irregularity on dynamic response due to a moving shear load.Design/methodology/approach– At first the authors developed the mathematical model for the problem which is comprised of equation of motion together with boundary conditions. Perturbation technique has been used to derive the stresses produced in an irregular orthotropic half-space (which is influenced by gravity) due to a moving shear load. MATLAB and MATHEMATICA softwares have been employed for numerical computation as well as graphical illustration.Findings– In this paper the authors have discussed the stresses produced in an irregular gravitating orthotropic half-space due to a moving shear load. The expression for shear stress has been established in closed form. Substantial effects of depth, irregularity factor, maximum depth of irregularity and gravitational parameter on shear stress have been reported. These effects are also exhibited by means of graphical illustration and numerical computation for an orthotropic material T300/5208 graphite/epoxy which is broadly used in aircraft designing. Moreover, comparison made through meticulous examination for different types of irregularity, presence and absence of anisotropy and gravity are highlighted.Practical implications– A number of classical fatigue failures occur in aircraft structures. The moving load responsible for such fatigue failure may occur during manufacturing process, servicing, etc. Apart from these the aircraft structures may also experience load because of environmental damages (such as lightning strike, overheat) and mechanical damages (like impact damage, overload/bearing failure). Therefore the present study is likely to find application in the field of construction of highways, airport runways and earthquake engineering.Originality/value– To the best of the authors’ knowledge no problem related to moving load on irregular orthotropic half-space under influence of gravity has been attempted by any author till date. Furthermore comparative study for different types of irregularity, presence and absence of anisotropy and influence of gravity on the dynamic response of moving load are novel and major highlights of the present study.
Plum Island Coffee Roasters: a perfect blend of coffee, business and community
Authors: Foudray Gregory C. 
Published: May 2016

Synopsis
The owner of an independent coffee shop is looking for methods to improve the sales performance of his business. He has strong customer sales and service skills but limited formal business education. He believes his sales are growing but seasonal volatility in sales is affecting his profitability. The manager of the coffee shop is a college student and is attempting to use methods from her business courses to analyze the impact of Facebook Advertising on the sales of the coffee shop. On a busy Friday in May, they are meeting to make key marketing decisions.

Research methodology
This case is a field researched case. The author had full access to the owner of the business, meeting with him frequently over a two-year period. The business owner has reviewed the case to verify its accuracy.

Relevant courses and levels
This case is intended for use in undergraduate business courses in the subject areas of Business, Marketing and Social/Digital Media Marketing.
Application of the Syllk model wiring an organisation for the capability of an online community of practice
Authors: Duffield Stephen Mark 
Published: May 2016

Purpose
This paper aims to demonstrate how to apply the systemic lessons learned knowledge (Syllk) model to enable the organisation for the capability of an online community of practice (CoP).

Design/methodology/approach
The research method consisted of multiple spiral “action research” cycles (plan, action, observe and reflect) within a government organisation. The initial planning stage consisted of interviews followed by two focus groups to identify the facilitators and barriers that impact the initial design of the Syllk model within the organisation. Established knowledge management practices were aligned with each of the Syllk elements to address the identified barriers and facilitate learning as the action cycles progressed. Online CoP initiatives were implemented with two action research cycles completed. Actions were observed, monitored, evaluated and reflected on using an after action review process.

Findings
The results from this research shows how the capability of a CoP can be “wired” (distributed) across organisational systems, and how the Syllk model can be used to conceptually facilitate this. The research highlights the importance in understanding organisational knowledge facilitators and barriers and the associated practices to reflect and learn from past experiences.

Research limitations/implications
The paper demonstrates an application of the Syllk model, and that action research can benefit project and knowledge management researchers and practitioners.

Practical implications
This study contributes to practice by highlighting how to use the Syllk model to “wire” an organisation for some know-how capability.

Originality/value
This study applies a conceptual model enabling management to understand how organisational know-how is distributed (wired) across various systems of an organisation for an online CoP.
The role of knowledge sharing culture in business performance
Authors: Marouf Laila 
Published: May 2016

PurposeThe aim of this study is to investigate the role of knowledge sharing (KS) culture in leveraging knowledge management (KM) strategy and human resource (HR) strategy to improve business performance (BP).Design/methodology/approachA structured questionnaire survey was distributed to 120 randomly selected companies in Kuwait. A total of 392 valid responses were collected and tested using a structural equation model. Statistical analysis was conducted using SPSS and LISREL software to verify the research hypotheses.FindingsThe results revealed the impact of the mediating variable KS culture on the enhancement of BP. Both KM strategy and HR strategy were observed to have a positive direct effect on KS culture.Practical implicationsThe results indicate that top management should make efforts to cultivate a KS culture to achieve better BP and future success.Originality/valueThe primary research contribution is the conceptual model for the role of KS culture as a mediator between KM strategy, HR strategy and BP.
Incorporation of poison center services in a state‐wide overdose education and naloxone distribution program
Authors: Doyon Suzanne , Benton Carleigh , Anderson Bruce A. , Baier Michael , Haas Erin , Hadley Lisa , Maehr Jennifer , Rebbert‐Franklin Kathleen , Olsen Yngvild , Welsh Christopher 
Published: May 2016

BackgroundTo help curb the opioid overdose epidemic, many states are implementing overdose education and naloxone distribution (OEND) programs. Few evaluations of these programs exist. Maryland's OEND program incorporated the services of the poison center. It asked bystanders to call the poison center within 2 hours of administration of naloxone. Bystanders included law enforcement (LE).ObjectiveDescription of the initial experience with this unique OEND program component.MethodsRetrospective case series of all cases of bystander‐administered naloxone reported to the Maryland Poison Center over 16 months. Cases were followed to final outcome, for example, hospital discharge or death. Indications for naloxone included suspected opioid exposure and unresponsiveness, respiratory depression, or cyanosis. Naloxone response was defined as person's ability to breathe, talk, or walk within minutes of administration.ResultsSeventy‐eight cases of bystander‐administered naloxone were reported. Positive response to naloxone was observed in 75.6% of overall cases. Response rates were 86.1% and 70.9% for suspected exposures to heroin and prescription opioids, respectively. Two individuals failed to respond to naloxone and died.DiscussionNaloxone response rates were higher and admission to the intensive care unit rates were lower in heroin overdoses than prescription opioid overdoses.ConclusionsThis retrospective case series of 78 cases of bystander‐administered naloxone reports a 75.6% overall rate of reversal.Scientific SignificanceThe findings of this study may be more generalizable. Incorporation of poison center services facilitated the capture of more timely data not usually available to OEND programs. (Am J Addict 2016;25:301–306)
Re‐irradiation using proton beam therapy combined with weekly intra‐arterial chemotherapy for recurrent oral cancer
Authors: Hayashi Yuichiro , Nakamura Tatsuya , Mitsudo Kenji , Kimura Kanako , Yamaguchi Hisashi , Ono Takashi , Azami Yusuke , Takayama Kanako , Hirose Katsumi , Yabuuchi Tomonori , Suzuki Motohisa , Hatayama Yoshiomi , Kikuchi Yasuhiro , Wada Hitoshi , Fuwa Nobukazu , Hareyama Masato , Tohnai Iwai 
Published: May 2016

AbstractAimThe purpose of this study was to clarify the efficacy and toxicities of re‐irradiation using proton beam therapy combined with weekly intra‐arterial chemotherapy for recurrent oral cancer.MethodsBetween October 2009 and July 2014, 34 patients who had recurrent oral cancer were treated by proton beam therapy combined with intra‐arterial infusion chemotherapy at the Southern Tohoku Proton Therapy Center, Japan.ResultsFor all patients, the median follow‐up was 25 months (range, 3–77 months). After treatment, 22 patients (65%) achieved a complete response, and 12 patients (35%) achieved a partial response at the primary tumor site. One‐year and 2‐year overall survival (OS) rates were 62% and 42%, respectively. One‐year and 2‐year LC rates were 77% and 60%, respectively. No treatment‐related deaths were observed during the treatment and follow‐up periods.ConclusionRe‐irradiation using proton beam therapy combined with weekly intra‐arterial chemotherapy improved OS and local control rates compared with other treatment modalities and could become a new treatment modality for patients with recurrent oral cancer.
Randomised clinical trial: a phase 1, dose‐ranging study of the anti‐matrix metalloproteinase‐9 monoclonal antibody GS‐5745 versus placebo for ulcerative colitis
Authors: Sandborn W. J. , Bhandari B. R. , Fogel R. , Onken J. , Yen E. , Zhao X. , Jiang Z. , Ge D. , Xin Y. , Ye Z. , French D. , Silverman J. A. , Kanwar B. , Subramanian G. M. , McHutchison J. G. , Lee S. D. , Shackelton L. M. , Pai R. K. , Levesque B. G. , Feagan B. G. 
Published: May 2016

SummaryBackgroundMatrix metalloproteinase‐9 is a proteolytic enzyme whose expression is increased in ulcerative colitis.AimTo evaluate the safety and efficacy of GS‐5745, a fully humanised anti‐matrix metalloproteinase‐9 monoclonal antibody, in moderately‐to‐severely active ulcerative colitis.MethodsWe randomised 74 patients with ulcerative colitis to treatment with single or multiple ascending intravenous or subcutaneous doses of GS‐5745 or placebo. Multiple‐dose cohorts received either IV infusions (0.3, 1.0, 2.5 or 5.0 mg/kg GS‐5745 or placebo) every 2 weeks (three total IV infusions) or five weekly SC injections (150 mg GS‐5745 or placebo). The primary outcomes were the safety, tolerability and pharmacokinetics of escalating single and multiple doses of GS‐5745. Exploratory analyses in the multiple‐dose cohorts included clinical response (≥3 points or 30% decrease from baseline in Mayo Clinic score and ≥1 point decrease in the rectal bleeding subscore or a rectal bleeding subscore ≤1) and clinical remission (a complete Mayo Clinic score ≤2 with no subscore >1) at Day 36. Biological effects associated with a clinical response to GS‐5745 were explored using histological and molecular approaches.ResultsTwenty‐three of the 42 patients (55%) receiving multiple doses of GS‐5745 had adverse events, compared with 5/8 patients (63%) receiving placebo. GS‐5745 showed target‐mediated drug disposition, approximately dose‐proportional increases in maximum plasma concentration and more than dose‐proportional increases in the area under the plasma drug concentration‐time curve. Clinical response occurred in 18/42 patients (43%) receiving GS‐5745 compared with 1/8 patients (13%) receiving placebo. Clinical remission occurred in 6/42 patients (14%) receiving GS‐5745 and 0/8 (0%) receiving placebo. Patients with a clinical response to GS‐5745 had reductions in matrix metalloproteinase‐9 tissue levels (mean 48.9% decrease from baseline compared with a mean 18.5% increase in nonresponders, P = 0.008) significant improvements in histopathology scores (confirmed with three separate histological disease activity indices), as well as changes in colonic gene expression that were consistent with reduced inflammation.ConclusionThis phase 1 trial provides preliminary evidence for the safety and therapeutic potential of GS‐5745 in the treatment of ulcerative colitis.
Visfatin Triggers the Cell Motility of Non‐Small Cell Lung Cancer via Up‐Regulation of Matrix Metalloproteinases
Authors: Wang Guanghai , Tian Wenjun , Liu Yiqing , Ju Ying , Shen Yajuan , Zhao Shengmei , Zhang Bingchang , Li Yu 
Published: May 2016

AbstractHigh levels of visfatin are correlated with worse clinical prognosis of various cancers. Still, the effects and mechanisms of visfatin on progression of non‐small cell lung cancer (NSCLC) remain unclear. This study revealed that plasma levels of visfatin in patients with NSCLC (585 ± 287 pg/ml) were significantly (p < 0.01) higher than those in healthy people (142 ± 61.1 pg/ml). The high level of plasma visfatin was found to be significantly (p < 0.05) correlated with TNM stage, lymph node metastasis and distant metastasis. Visfatin treatment can increase the migration and invasion of NSCLC cells via up‐regulation of metalloproteinase‐2 (MMP‐2) and MMP‐9. Both si‐MMP‐2 and si‐MMP‐9 attenuated visfatin‐induced migration of NSCLC cells. The inhibitor of NF‐κB, while not ERK1/2, p38‐MAPK or PI3K/Akt, can significantly abolish visfatin‐induced migration of A549 cells and up‐regulation of MMP‐2 and MMP‐9. Furthermore, visfatin can increase the phosphorylation of IκBα and p65 and the transcription activities of NF‐κB in NSCLC cells. ACHP, the inhibitor of IKK‐β, blocked visfatin‐induced activation of p65 and up‐regulation of MMP‐2 and MMP‐9. Collectively, our data revealed that visfatin can trigger the in vitro migration and invasion of NSCLC cells via up‐regulation of MMPs through activation of NF‐κB.
Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL‐XL (BCL2L1)
Authors: Delbridge Alex R. D. , Chappaz Stephane , Ritchie Matthew E. , Kile Benjamin T. , Strasser Andreas , Grabow Stephanie 
Published: May 2016

SummaryApoptosis is required to maintain tissue homeostasis in multicellular organisms. Platelets, the anucleate cells that are essential for blood clotting, are a prime example. Their brief life span in the circulation is regulated by the intrinsic apoptosis pathway. Pro‐survival BCL‐XL (also termed BCL2L1) is essential for platelet viability. It functions to restrain the pro‐apoptotic BCL‐2 family members BAK (also termed BAK1) and BAX, the essential mediators of intrinsic apoptosis. Genetic deletion or pharmacological inhibition of BCL‐XL results in thrombocytopenia. Conversely, deletion of BAK in platelets doubles their circulating life span. However, what triggers platelet apoptosis in vivo remains unclear. The pro‐apoptotic BH3‐only proteins are essential for initiating apoptosis in nucleated cells, and there is some evidence to suggest they also play a role in platelet biology. We investigated whether PUMA (also termed BBC3), a potent BH3‐only protein that can inhibit all pro‐survival BCL‐2 family members as well as directly activate BAX, regulates the death of platelets. Surprisingly, loss of PUMA had no impact on the loss of platelets caused by loss of BCL‐XL. It therefore remains to be established whether other BH3‐only proteins play a critical role in induction of apoptosis in platelets or whether their death is controlled solely by the interactions between BCL‐XL with BAK and BAX.
Convolutional Sparse Coding for High Dynamic Range Imaging
Authors: Serrano Ana , Heide Felix , Gutierrez Diego , Wetzstein Gordon , Masia Belen 
Published: May 2016

AbstractCurrent HDR acquisition techniques are based on either (i) fusing multibracketed, low dynamic range (LDR) images, (ii) modifying existing hardware and capturing different exposures simultaneously with multiple sensors, or (iii) reconstructing a single image with spatially‐varying pixel exposures. In this paper, we propose a novel algorithm to recover high‐quality HDRI images from a single, coded exposure. The proposed reconstruction method builds on recently‐introduced ideas of convolutional sparse coding (CSC); this paper demonstrates how to make CSC practical for HDR imaging. We demonstrate that the proposed algorithm achieves higher‐quality reconstructions than alternative methods, we evaluate optical coding schemes, analyze algorithmic parameters, and build a prototype coded HDR camera that demonstrates the utility of convolutional sparse HDRI coding with a custom hardware platform.
Roles of FGFR in oral carcinogenesis
Authors: Xie Xiaoyan , Wang Zhiyong , Chen Fangman , Yuan Yao , Wang Jiayi , Liu Rui , Chen Qianming 
Published: May 2016

AbstractFibroblast growth factor receptors (FGFRs) play essential roles in organ development during the embryonic period, and regulate tissue repair in adults. Accumulating evidence suggests that alterations in FGFR signalling are involved in diverse types of cancer. In this review, we focus on aberrant regulation of FGFRs in pathogenesis of oral squamous cell carcinoma (OSCC), including altered expression and subcellular location, aberrant isoform splicing and mutations. We also provide an overview of oncogenic roles of each FGFR and its downstream signalling pathways in regulating OSCC cell proliferation and metastasis. Finally, we discuss potential application of FGFRs as anti‐cancer targets in the preclinical environment and in clinical practice.
Pharmacokinetics of prolonged‐release tacrolimus and implications for use in solid organ transplant recipients
Authors: Tanzi Maria G. , Undre Nasrullah , Keirns James , Fitzsimmons William E. , Brown Malcolm , First M. Roy 
Published: May 2016

AbstractProlonged‐release tacrolimus was developed as a once‐daily formulation with ethylcellulose as the excipient, resulting in slower release and reduction in peak concentration (Cmax) for a given dose compared with immediate‐release tacrolimus, which is administered twice daily. This manuscript reviews pharmacokinetic information on prolonged‐release tacrolimus in healthy subjects, in transplant recipients converted from immediate‐release tacrolimus, and in de novo kidney and liver transplant recipients. As with the immediate‐release formulation, prolonged‐release tacrolimus shows a strong correlation between trough concentration (Cmin) and area under the 24‐hour time–concentration curve (AUC24), indicating that trough whole blood concentrations provide an accurate measure of drug exposure. We present the pharmacokinetic similarities and differences between the two formulations, so that prescribing physicians will have a better understanding of therapeutic drug monitoring in patients receiving prolonged‐release tacrolimus.