bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic polymorphisms associated with preeclampsia risk in Nigerian women
Authors: Olaniyan Mathew F. , Akpoyovwere Obataze J. , Kanikwu Nwamaka P. , Olaniyan Tolulope B. , Adeniran Medinat T. , Muhibi Musa A. , Odegbemi Odekunle B. 
Published: September 2024

Abstract
Background
Preeclampsia, a complex hypertensive disorder unique to pregnancy, significantly impacts maternal and fetal health worldwide, with a prevalence of 2–8%. This condition results from a complex interplay of genetic, environmental, and immunological factors.

Aim and objectives
This study aims to investigate the genetic predispositions to preeclampsia, focusing on specific gene polymorphisms among pregnant women at Central Hospital Auchi, Nigeria.

Materials and methods
We examined the endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF), angiotensin-converting enzyme (ACE), and tumor necrosis factor-alpha (TNF-α) genes in 200 pregnant women, equally divided between preeclamptic patients and normotensive controls.

Results
The eNOS G894T polymorphism was significantly associated with preeclampsia, with the T allele nearly doubling the risk. The VEGF C936T polymorphism's T allele also indicated a higher risk. The D allele in the ACE gene's insertion/deletion (I/D) polymorphism significantly increased the risk, as did the A allele in the TNF-α G308A polymorphism.

Conclusions
These findings highlight the importance of genetic factors in preeclampsia and suggest that genetic screening could improve risk stratification and early detection. Future research should integrate genetic, epigenetic, and environmental data to understand preeclampsia's multifaceted nature and develop targeted therapies. This study underscores the potential of personalized medicine in managing and reducing the risks associated with preeclampsia.
Oral manifestations in children with congenital Zika virus syndrome: a systematic review
Authors: Gallo Maria Júlia Delsin , Molena Kelly Fernanda , de Almeida dos Santos Thalia Carvalho , de Carvalho Fabrício Kitazono , Paula e Silva Francisco Wanderley Garcia , Feres Murilo Fernando Neuppmann , de Queiroz Alexandra Mussolino 
Published: September 2024

Abstract
Background
Congenital Zika Syndrome (CZS) comprises congenital anomalies that occur in individuals, embryos or fetuses exposed to Zika virus infection during pregnancy and can result in systemic manifestations as well as alterations in the oral cavity of these children. The aim of this study was to conduct a systematic literature review of the most frequent oral and craniofacial manifestations in children aged 0 to 6 years with CZS compared to neurotypical children without CZS.

Main body of the abstract
In this review, a search was conducted in the PubMed, Medline, Embase, Web of Science databases and grey literature, as well as a manual search of the reference lists of the included articles, without restriction on year or language. Inclusion criteria were studies reporting oral alterations in children up to six years old or newborns with CZS, with or without a control group. Methodological quality of the studies was assessed by the Mixed Methods Appraisal Tool (MMAT). Twenty-seven articles were retrieved, 19 quantitative non-randomized and 09 quantitative descriptive studies. Three studies presented a high risk of bias. The main reported manifestations were delayed eruption (51,8%), dental enamel defects (25,9%), deep palate (29,6%), number alterations (14,8%), bruxism (29,6%), and malocclusion (25,9%).

Short conclusion
CZS can lead to several manifestations of dental interest and may interfere with the individual's oral health. The pediatric dentistry thus requiring the dentist to be attentive to these changes to offer the best and comprehensive treatment to this patient.
Application of artificial neural network for peak load forecasting in 150 kV Semarang power system
Authors: Fakhryza Khamdan Annas , Budisusila Eka Nuryanto , Nugroho Agus Adhi 
Published: September 2024

AbstractAccurate load forecasting is essential for reliable and efficient operation of power systems. Traditional forecasting methods often struggle with capturing complex nonlinear patterns in load data. Artificial neural networks (ANNs) have emerged as a promising alternative due to their ability to learn complex relationships from historical data (Syed et al. in IEEEA 9:54992–55008, 2021. https://doi.org/10.1109/ACCESS.2021.3071654). This study investigates the potential of ANNs for short-term peak load forecasting in a 150 kV power system in Semarang, Indonesia. The study examines the impact of different input variables, including historical peak load, minimum load, population, and energy production, on forecasting accuracy. Several ANN architectures are trained and evaluated using mean absolute percentage error (MAPE) and mean squared error (MSE) metrics as reported by Demuth and De Jesús (neural network design). The results indicate that ANNs can achieve high accuracy in predicting peak load, with MAPE values below 10%. The study also demonstrates the importance of carefully selecting input variables and training parameters for optimal model performance. The findings highlight the potential of ANNs for improving load forecasting accuracy in power systems, contributing to enhanced grid reliability and operational efficiency. The findings of this study contribute to a deeper understanding of the application of ANNs in power system load forecasting. They demonstrate the potential of ANNs to achieve high accuracy and provide valuable insights into the factors influencing model performance. The findings are relevant for power system operators, researchers, and policymakers working to improve grid reliability and efficiency as reported by Prabha Kundur and Malik (Power System Stability and Control, McGraw-Hill Education, New York, 2022. https://www.accessengineeringlibrary.com/content/book/9781260473544).
Le tout dernier Baudelaire
Authors: Thériault Patrick 
Published: October 2024

Résumé
Par la raideur intransigeante de sa posture tout autant que par la violence hyperbolique de son discours, le « tout dernier Baudelaire » de Belgique rappelle le prophète de malheurs, en sa version ancienne, vétérotestamentaire ; mais il l’annonce aussi, en sa version moderne : comme en témoignent les notes composant le dossier préparatoire de La Belgique déshabillée, il préfigure à certains égards un profil d’écrivain-journaliste qui jouera un rôle de premier plan dans l’espace intellectuel de la Troisième République et en lequel on peut reconnaître l’avatar du prophète de malheur le plus emblématique du dix-neuvième siècle, à savoir le pamphlétaire. C’est ce que nous proposons ici de démontrer, en considérant un fragment à résonance apocalyptique de La Belgique déshabillée en regard de l’introduction de La Fin d’un monde d’Édouard Drumont.
Exercise, Sports Participation, and Quality of Life in Young Patients with Heritable Thoracic Aortic Disease
Authors: MILLETTE THEODORE J. , RAMCHARITAR RANDY K. , MONFREDI OLIVER J. , THOMAS MATTHEW J. , CONAWAY MARK R. , DEAN PETER N. 
Published: October 2024

ABSTRACT

Introduction
Patients with heritable thoracic aortic disease (HTAD) are often restricted from sports and certain types of exercise. This study was designed to investigate the effect of lifetime exercise exposure and competitive sports participation on quality of life (QOL) in patients 15–35 yr old with syndromic (Marfan syndrome, Loeys–Dietz syndrome, and vascular Ehlers–Danlos syndrome) and nonsyndromic HTAD (nsHTAD).

Methods
This cross-sectional study used questionnaires to assess lifetime exercise exposure and utilized the PedsQL QOL Inventory. We developed an exercise exposure score (EES) to quantify lifetime exercise exposure. Questionnaires were completed via telephone with complimentary medical record review.

Results
Forty patients were enrolled. Mean age was 26 yr. The diagnosis was Marfan syndrome in 83%. Despite 88% of patients being restricted by their provider, 65% reported competitive sports participation and 93% reported recreational exercise. Participants with an EES greater than the median had significantly better total QOL scores compared with those below the median (78 vs 65, P = 0.03). There were significant positive correlations between current frequency of exercise and psychosocial QOL (slope = 3.9, 95% CI = 1.2–6.6, P = 0.005), physical QOL (slope = 8.1, 95% CI = 4.1–12, P < 0.001), and total QOL score (slope = 6.0, 95% CI = 3.1–9.0, P < 0.001). We found no difference in aortic size or need for surgical intervention between those above and below the median EES, or between those who did and did not participate in competitive sports.

Conclusions
Despite exercise restrictions, young HTAD patients are physically active. Increased lifetime exercise and current physical activity levels were associated with improved QOL in HTAD patients.
The impact of ethnicity on care and outcome after hip fracture in England and Wales
Authors: Nisar Sohail , Lamb Jonathan , Johansen Antony , West Robert , Pandit Hemant 
Published: October 2024

AimsTo determine if patient ethnicity among patients with a hip fracture influences the type of fracture, surgical care, and outcome.MethodsThis was an observational cohort study using a linked dataset combining data from the National Hip Fracture Database and Hospital Episode Statistics in England and Wales. Patients’ odds of dying at one year were modelled using logistic regression with adjustment for ethnicity and clinically relevant covariates.ResultsA total of 563,640 patients were included between 1 April 2011 and 1 October 2020. Of these, 476,469 (85%) had a coded ethnicity for analysis. Non-white patients tended to be younger (mean 81.2 vs 83.0 years), and were more commonly male (34.9% vs 28.5%; p < 0.001). They were less likely to be admitted from institutional care (12.9% vs 21.8%; p < 0.001), to have normal cognition (53.3% vs 62.0%; p < 0.001), and to be free of comorbidities (22.0% vs 26.8%; p < 0.001), but were more likely to be from the most deprived areas (29.4% vs 17.3%; p < 0.001). Non-white patients were more likely to experience delay to surgery for medical reasons (14.8% vs 12.7%; p < 0.001), more likely to be treated with an intramedullary nail or a sliding hip screw (52.5% vs 45.1%; p < 0.001), and less likely to be mobilized by the day after surgery (74.3% vs 79.0%; p < 0.001). Mortality was higher among non-white inpatients (9.2% vs 8.4% for white), but was lower at one year after hip fracture (26.6% vs 30.3%).ConclusionOur study identified serious problems with the quality of NHS ethnicity data. Despite this, we have shown that there is complex variation in case-mix and hip fracture morphology between ethnic groups. We have also identified variations in care received between ethnic groups, and that disparities in healthcare may contribute to poorer outcome. Inpatient mortality is higher in non-white patients, although this finding reverses after discharge, and one-year mortality is lower. Patients from ethnic minority backgrounds experience disparities in healthcare, however at one year postoperatively non-white patients have a statistically significant lower mortality after controlling for relevant clinical covariates.Cite this article: Bone Joint J 2024;106-B(10):1182–1189.
Elbow kinematics with increased lengthening of a radial head arthroplasty evaluated with dynamic radiostereometric analysis
Authors: Frost Teilmann Johanne , Petersen Emil T. , Thillemann Theis M. , Hemmingsen Chalotte K. , Olsen Kipp Josephine , Falstie-Jensen Thomas , Stilling Maiken 
Published: October 2024

AimsThe aim of this study was to evaluate the kinematics of the elbow following increasing length of the radius with implantation of radial head arthroplasties (RHAs) using dynamic radiostereometry (dRSA).MethodsEight human donor arms were examined by dRSA during motor-controlled flexion and extension of the elbow with the forearm in an unloaded neutral position, and in pronation and supination with and without a 10 N valgus or varus load, respectively. The elbows were examined before and after RHA with stem lengths of anatomical size, + 2 mm, and + 4 mm. The ligaments were maintained intact by using a step-cut lateral humeral epicondylar osteotomy, allowing the RHAs to be repeatedly exchanged. Bone models were obtained from CT scans, and specialized software was used to match these models with the dRSA recordings. The flexion kinematics of the elbow were described using anatomical coordinate systems to define translations and rotations with six degrees of freedom.ResultsThe greatest kinematic changes in the elbows were seen with the longest, + 4 mm, implant, which imposed a mean joint distraction of 2.8 mm in the radiohumeral joint and of 1.1 mm in the ulnohumeral joint, an increased mean varus angle of up to 2.4° for both the radius and the ulna, a mean shift of the radius of 2.0 mm in the ulnar direction, and a mean shift of the ulna of 1.0 mm posteriorly.ConclusionThe kinematics of the elbow deviated increasingly from those of the native joint with a 2 mm to a 4 mm lengthening of the radius. This confirms the importance of restoring the natural length of the radius when undertaking RHA.Cite this article: Bone Joint J 2024;106-B(10):1165–1175.
Hypervitaminosis D Associated with a Vitamin D Dispensing Error
Authors: Jacobsen Ryan B , Hronek Brett W , Schmidt Ginelle A , Schilling Margo L 
Published: September 2024

Objective: To report a case of hypervitaminosis D resulting in hypercalcemia and acute kidney injury in a 70-year-old female who was prescribed a standard dose of vitamin D but given a toxic dose of vitamin D 50.000 IU (1.25 mg) daily resulting from a dispensing error. Case Summary: A 70-year-old female in her usual state of health was instructed to begin supplementation with vitamin D 1000 IU dairy. Three months later she developed contusion, slurred speech, unstable gait, and increased fatigue. She was hospitalized for hypercalcemia and acute kidney injury secondary to hypervitaminosis D. All vitamin D supplementation was discontinued and 5 months after discharge, the patient's serum calcium and vitamin D concentrations, as well as renal function, had returned to baseline values. Upon review of the patient's records, it was discovered that she had been taking vitamin D 50,000 IU daily. Discussion: There is an increased interest in vitamin D, resulting in more health care providers recommending—and patients taking—supplemental vitamin D. Hypervitaminosis D is rarely reported and generally only in the setting of gross excess of vitamin D. This report highlights a case of hypervitaminosis D in the setting of a prescribed standard dose of vitamin D that resulted in toxic ingestion of vitamin D 50,000 IU daily due to a dispensing error. As more and more people use vitamin D supplements, it is important to recognize that, while rare, hypervitaminosis D is a possibility and dosage conversion of vitamin D units can result in errors. Conclusions: Health care providers and patients should be educated on the advantages and risks associated with vitamin D supplementation and be informed of safety measures to avoid hypervitaminosis D. in addition, health care providers should understand dosage conversion regarding vitamin D and electronic prescribing and dispensing software should be designed to detect such errors.
Economic Impact of Pharmacists' Interventions with Nonsteroidal Antiinflammatory Drugs
Authors: Guignard Adrienne P , Couray-Targe Sandrine , Colin Cyrille , Chamba Geneviève 
Published: September 2024

OBJECTIVE: To estimate the economic impact of community pharmacists' interventions following the detection of problems related to nonsteroidal antiinflammatory drugs (NSAIDs), whether in a prescription or self-medication format. The evaluation focused on the gastroduodenal adverse events that could be avoided and the subsequent savings of healthcare resources spent on treating these adverse effects. METHODS: A previous study conducted during a 12-week period in 924 French community pharmacies provided the number of interventions for drug-related problems concerning NSAIDs. A simulation model was constructed to compare 2 strategies: a systematic pharmacist's intervention and the absence of intervention. The base-case patient was assumed to have been taking an NSAID for 3 months. The model's inputs were extracted from medical literature and from an institutional medical database. RESULTS: In this study, 608 interventions were the results of NSAID-related problems. All of these interventions reduced the risk of gastrointestinal adverse events and avoided a total cost of 37 300. CONCLUSIONS: This model indicates that the dispensing of NSAIDs by pharmacists and related pharmaceutical care activities have a positive impact by reducing the number of gastrointestinal complications. The model quantifies the costs thus avoided. It also underlines the necessity of effective collaboration between the prescriber and the pharmacist if optimal patient management is to be achieved.
Elevated Creatine Kinase and Myalgia in a Patient Taking Rosiglitazone
Authors: Kennie Natalie , Antoniou Tony , Berger Philip 
Published: September 2024

Objective: To report a case of rosiglitazone-associated elevation in creatine kinase (CK) and coexisting myalgias and review other cases identified in the literature. Case Summary: A 42-year-old man originally from Sri Lanka developed an elevated CK, with peak concentrations of 1671 U/L (normal <160) and myalgias following 5 months of therapy with rosiglitazone. Signs and symptoms recurred upon rechallenge 3 years later. Other potential medical and medication causes were ruled out. Independent assessment by 2 raters using the Naranjo probability scale suggested a probable relationship with rosiglitazone. Discussion: Only 5 previous reports of elevated CK, myalgias, myopathy, or rhabdomolysis in patients taking rosiglitazone or other thiazolidinediones were identified in the literature. Potential risk factors identified from previously published reports included concomitant therapy with fibrates, excessive use of ethanol, and asymptomatic mild CK elevation prior to starting therapy. Based on this case report, it seems reasonable to monitor CK levels in patients on rosiglitazone who are experiencing muscle symptoms or who have a history of myopathy. Conclusions: Marked elevations of CK and muscle pain may be a possible adverse reaction of rosiglitazone therapy.
Corticosteroid Interactions with Cyclosporine, Tacrolimus, Mycophenolate, and Sirolimus: Fact or Fiction?
Authors: Lam Stefanie , Partovi Nilufar , Ting Lillian SL , Ensom Mary HH 
Published: September 2024

Objective: To review the current clinical evidence on the effects of corticosteroid interactions with the immunosuppressive drugs cyclosporine, tacrolimus, mycophenolate, and sirotimus. Data Sources: Articles were retrieved through MEDLINE (1966–February 2008) using the terms corticosteroids, glucocorticoids, immunosuppressants, cyclosporine, tacrolimus, mycophenolate, sirolimus, drug Interactions, CYP3A4, P-glycoprotein, and UDP-glucuronosyltransferases. Bibliographies were manually searched for additional relevant articles. Study Selection and Data Extraction: All English-language studies dealing with drug interactions between corticosteroids and cyclosporine, tacrolimus, mycophenolate, and sirolimus were reviewed. Data Synthesis: Corticosteroids share common metabolic and transporter pathways, the cytochrome P450 and P-glycoprotein (P-gp/ABCB1) systems, respectively, with cyclosporine, tacrolimus, and sirolimus. As a group, corticosteroids Induce the CYP3A4 and P-gp pathways; however, a tew exceptions exist and the impact on a patient's immunosuppressant regimen may be critical. Corticosteroids also have demonstrated an induction effect on the uridine diphos-phate–glucuronosyltransferase enzymes and multidrug resistance–associated protein 2 involved in mycophenolate's disposition. Successful corticosteroid withdrawal regimens have been reported; however, only few studies have examined the effects of steroid withdrawal on the remaining immunosuppressive regimens. To date, the clinical impact of steroid withdrawal on disposition of other immunosuppressive agents is not well characterized, and reports of such drug-drug interactions are conflicting. Conclusions: While our understanding of the clinical impact of sterokHmmuno-suppressant interactions is limited, it remains a fact that corticosteroids have complex Induction and inhibition interactions with common metabolic and transport pathways. Given the complex interaction of corticosteroids on crucial metabolic enzymes and transporter proteins, monitoring of immunosuppressive agents during steroid withdrawal is warranted to ensure optimal treatment outcomes.
Barriers to Clopidogrel Adherence Following Placement of Drug-Eluting Stents
Authors: Pallares Maria José , Powers Eric R , Zwerner Peter L , Fowler Andrew , Reeves Rodney , Nappi Jean M 
Published: September 2024

Background: Nonadherence to clopidogrel after drug-eluting stent (DES) placement is associated with in-stent thrombosis and adverse cardiac events. Objective: To identify the incidence of and barriers associated with nonadherence to clopidogrel in patients receiving DES. Methods: Patients who received a DES between March 1, 2004, and August 31, 2005, from a single academic medical center were eligible. Telephone interviews were conducted 6 or more months following discharge. Nonadherence was defined as premature discontinuation of or less than 80% adherence to clopidogrel. Patients were asked to identify barriers to adherence. Differences between adherent and nonadherent patients were analyzed using χ2 and t-test analysis. Results: Of the 674 patients identified, 257 (38%) participated. The nonadherence rate was 20%. The majority (58%) of nonadherent patients discontinued therapy prematurely. Patients identified the main reason for discontinuation as medical barriers (18.56%), including perceived adverse effects (9.28%). The Incidence of rash was higher in patients who were nonadherent (12% vs 4%; p = 0.049). Overall, 49% of patients recalled receiving discharge counseling regarding adverse effects. A financial barrier was identified by 22 (42%) patients in the nonadherent and 73 (36%) in the adherent group, of whom 64% and 52%, respectively, reported having insurance coverage for medications. Adherent patients reported higher copays ($29.69 vs $18.14; p = 0.01). Conclusions: Prospective studies should be conducted to aid in identifying patients at risk for nonadherence and possible in-stent thrombosis in order to identify interventions to improve adherence.
Possible Zoophilia Associated with Dopaminergic Therapy in Parkinson Disease
Authors: Jiménez-Jiménez Félix Javier , Sayed Youssef , García-Soldevilla Miguel Angel , Barcenilla Beatriz 
Published: September 2024

OBJECTIVE: To report a patient with Parkinson disease (PD) who developed zoophilia as a possible complication of dopaminergic therapy. CASE SUMMARY: A 74-year-old man with advanced PD, who had wearing-off motor fluctuations, with a marked disability during the off periods and severe peak-of-dose choreiform dyskinesias, developed hypersexuality with zoophilia 5 days after standard levodopa was substituted for controlled-release levodopa and the dose of bromocriptine was increased. The abnormal sexual behavior disappeared 2 days after the doses of standard levodopa and of bromocriptine were reduced. DISCUSSION: Hypersexuality is a known complication in PD patients undergoing dopaminergic therapy. However, the possible development of zoophilia due to these drugs, as was the case in our patient, is exceptional. CONCLUSIONS: Zoophilia should be considered as a possible behavioral complication of dopaminergic therapy in PD patients.