bluuebunny/crossref_metadata_2025_split huggingface dataset:
P071 ASSOCIATION BETWEEN DIFFERENT TIMEPOINT AND THRESHOLD-CALCULATED TIME-IN-SYSTOLIC-BLOOD-PRESSURE-TARGET-RANGE AND INCIDENT MAJOR ADVERSE CARDIOVASCULAR EVENTS: INSIGHT FROM THE SPRINT TRIAL
Authors: Li Moran , Shi Jieying , Hou JingJing , Zhao Yifan , Zhang Yi 
Published: September 2024

Objective:
To evaluate the prognostic value of different timepoint and threshold of systolic blood pressure (SBP) Time in Target Rang (TTR) in Major Adverse Cardiovascular Events (MACEs).
Method: A post-hoc analysis of the SPIRNT trial was conducted. Participants with complete BP data and no adverse events occurred in next 2-years follow-up were enrolled. SBP TTR was calculated at different timepoints (3, 12, 24 months) and thresholds (110-130mmHg; 110-140mmHg; 110-130mmHg for intensive and 120-140mmHg for standard treatment groups)(Fig 1). The primary outcome was MACEs occurred 2 years later, defined as the composite of myocardial infarction, stroke, heart failure and cardiovascular death.

Results:
7134 participants in SPIRNT were enrolled in this study. SBP TTR indexes with independent predictive value of MACEs were selected by multivariable COX models adjusted for basic cardiovascular risk factors (Fig 2). Multivariable COX models identified SBP TTR calculated with 110-140mmHg threshold over 3 months (3month SBP TTR110-140) as the best predictor of MACEs. (Table 1). the nonlinear trend of 3month SBP TTR110-140 was also evaluated. (Fig 3) Then, a cut-off value of 0.65 for 3month SBP TTR110-140 was obtained by the point with the largest likelihood value in the RCS curve.(Fig 3). Patients with 3month TTR110-140 > 0.65 had 23.9% lower incidence of MACEs than patients with TTR ≤ 0.65 (HR 0.761[0.592-0978], P=0.033).(Table 2) In addition, for patients with early SBP well-control (3month SBP TTR110-140 >0.65), there was no significant difference in mean SBP between 110-130 mmHg and 130-140 mmHg (Fig4). Lasso regression also suggests that TTR110-140 has more informatics advantages than TTR110-130 in cox model at different timepoints (Fig5).

Conclusions:
3month SBP TTR110-140 was considered to be the best predictor of MACEs occurred 2 years later in different SBP TTR indexes, which indicated the importance of early SBP control. This study also proposed 0.65 as the critical value of 3-month SBP TTR110-140 for prevention of the incident of MACEs.
P083 CHANGES IN STANDARD CUFF AND CENTRAL BLOOD PRESSURES ARE EQUALLY ASSOCIATED WITH CHANGES IN LEFT VENTRICULAR MASS: LONGITUDINAL ANALYSIS FROM THE UK BIOBANK COHORT STUDY
Authors: Sharman James , Takeuchi Fumihiko , Protogerou Athanase , Weber Thomas , Wassertheurer Siegfried , Marwick Thomas 
Published: September 2024

Background and objective.
Central blood pressure (BP) measurement purports to aid hypertension management. This concept is founded on cross-sectional studies, however, findings are mixed and none report longitudinal relationships between changes in BP and outcomes. This study aimed to determine associations of changes in cuff BP and central BP with changes in left ventricular mass index (LVMi), as an important hypertension-related clinical outcome.

Methods.
Standard cuff BP and central BP (Vicorder, Skidmore Medical, UK; SBP/DBP calibration of waveforms) were measured at the same time as cardiac magnetic resonance imaging for LVMi among a cohort of adults from the UK Biobank Cohort Study assessed at two time points (2014+ and 2019+). Linear regression adjusted for demographic and clinical characteristics were used to determine cross sectional associations and associations between changes in cuff BP and central BP with LVMi.

Results.
Data were evaluable for 681 participants (aged 50.1±7.1 years, 54% female) followed over 1161±582 days (mean ± SD). Cross-sectional analysis showed the association of cuff systolic BP with LVMi (β±SE 3.47x10-2±6.38x10-3 g/m2.7/mmHg) and central systolic BP with LVMi (β±SE=3.52x10-2±6.40x10-3 g/m2.7/mmHg) were comparable (p<0.001 both). In the longitudinal analysis, associations between the changes in BP and changes in LVMi were identical for both central and cuff systolic BP (β±SE=0.011±0.003 g/m2.7/mmHg; p<0.001 both).

Conclusion.
Changes over time in standard cuff BP provides similar information to central BP on risk for hypertension-related changes in LVMi. These findings are likely to be generalisable to central BP devices using SBP/DBP calibration.
P088 VASCULAR HYPERREACTIVITY IS RELATED TO SHORTENING FRACTION AND LEFT VENTRICULAR MASS IN YOUNG NORMOTENSIVES
Authors: Rufino Nuñez Harline Raquel , Carmona Puerta Raimundo , Lorenzo Martinez Dra Elizabeth , Sanchez Dra Marielys del Carmen Martinez , Batista Dra Yahaira A. Flete , Gómez Calderón Jose B. , Peñaló Batista Joel 
Published: September 2024

Summary

Background and objective:
Vascular reactivity has been related to left ventricular hypertrophy, but there are insufficient data on whether this relationship involves left ventricular (LV) contractility. Our aim was to relate the degree of cardiovascular reactivity to LV mass and contractility.

Methods:
A cross-sectional study was carried out in normotensive men aged 16-40 years, divided into 2 groups of 30 individuals according to the degree of vascular reactivity determined by the sustained weight test. The LV mass index (LVMI) and the shortening fraction were determined by transthoracic echocardiography.

Results:
LVMI was found to be significantly higher in hyperreactive than in normoreactive patients (123.57 g/m2 vs. 105.10 g/m2 p<0.01) and the shortening fraction in hyperreactive patients was significantly lower than in normoreactive patients (31.21% vs. 33.78% p<0.05). This difference increased in the subgroup of hyper-reactive patients with left ventricular hypertrophy and disappeared in hyper-reactive patients without hypertrophy when compared in each case with normoreactive patients.

Conclusions:
Hyperreactivity status is related to lower shortening fraction and greater left ventricular mass in young normotensive males.
P092 THE EFFECT OF HYPERTENSION ON THE UTILITY OF ECHOCARDIOGRAM AS AS SUBSTITUTE OF CARDIAC SCNINTIGRAPHY TO DETECT CARDIAC ISCHEMIA
Authors: Miyahara Yuiko , Hirai Takumu , Sakida Miho , Kubo Kazuhiko 
Published: September 2024

Background and Objective:
The cardiac scintigraphy is worthwhile to detect ischemia instead of cardiac catheterization, whereas the echocardiogram is useful to detect movement of myocardium and valves but not to detect ischemia. It is beneficial to predict ischemia by echocardiogram because the disadvantage of cardiac scintigraphy is to be expensive and to expose radiation. The objective of the current study is to evaluate whether the echocardiogram is substituted for the cardiac scintigraphy in the patients with ischemic heart disease and to assess the effect of hypertension on the correlation of two examinations.

Methods:
We recruited 101 patients with ischemic heart disease who were admitted to Chidoribashi General Hospital and underwent both echocardiogram and cardiac scintigraphy from April 2021 to March 2023. They were divided to two groups by the presence and absence of hypertension at admission. The various parameters of echocardiogram and cardiac scintigraphy were collected retrospectively. The correlation was statistically tested using JMP Pro 17. This study was approved by our ethical committee.

Results:
In the risk factors of poor prognosis, left ventricular end-systolic volume, summed stress score and ejection fraction (EF) from cardiac scintigraphy were correlated with left ventricular internal dimension (LVD) on echocardiogram. In contrast, summed difference score was correlated with LVD in systole and EF on echocardiogram in the patients without hypertension but not in the patients with hypertension.

Conclusions:
These results suggest that LVD of echocardiogram may become an indicator to detect cardiac ischemia instead of cardiac scintigraphy.
P097 SEXUAL DIMORPHISM IN A HYPERTENSIVE MODEL OF FRUCTOSE PLUS HIGH SALT DIET
Authors: Araos Patricio , Marfull BS. Rominna , Durán Anyelo , Alfaro Juan José , Fernand Matthias , Torres Sven , Gutiérres Harold , Sáez Javiera , Amador Cristián A. , Wynne Brandi 
Published: September 2024

High salt diet (HSD) and fructose are both consumed in excess and contributes to hypertension (HTN). Fructose is commonly used to sweeten soft drinks, and studies have linked soft drink consumption to salt-sensitive HTN. However, full mechanisms aren’t understood. Previous data indicates that an acute fructose-enriched diet (FED) increases Na/K/2Cl cotransporter (NKCC2) activity, promoting salt-sensitive HTN in rats; however, there is no research on long-term consumption. Here, our goal was to evaluate whether a FED, coupled to HSD, can induce HTN. Given the known sex-dependent differences in salt-sensitive HTN, we also hypothesized differences between male and female mice.
Male and female C57BI/6 mice (10 weeks old, n=4-6) were treated with vehicle or fructose (10% in drinking water) plus HSD (4% in food) for 28 days. Systolic blood pressure (SBP) was measured by tail-cuff plethysmography, and cardiac hypertrophy (morphometry). We performed an acute diuresis test using furosemide to inhibit NKCC2 (20 mg/kg bw, ip) at day 26, and then measured natriuresis (metabolic cages) for 2-hrs. All data are presented by mean standard deviation.
Fructose+HSD increased SBP in male mice after 28 days (Veh=110.5±4.6 vs. Frucose+HSD=130.2±5.6 mmHg; p<0.01); in contrast, HTN was completely prevented in female mice (Veh=109.8±6.8 vs. Fructose+HSD=114.0±11.0 mmHg; ns). We did not observe changes in cardiac hypertrophy in either sex. We observed a significant decrease in natriuresis (∼20%) after furosemide injection in male mice (Veh=5.9±1.1 vs. Fructose+HSD=4.7±0.8 μEq/2 h/g bw; ns). Surprisingly, we observed an increase in natriuresis following furosemide injection in female mice (Veh=3.8±5.0 vs. Fructose+HSD= 7.7±2.7 μEq/2 h/g bw; p<0.01).
We observed HTN in males following a FED combined with HSD, which was not associated with increased NKCC2 activation. In contrast, female mice showed a resistance to HTN, and yet an apparent increase in NKCC2 activity. This probably suggests a dysregulation of other transporters not evaluated in this work. Finally, we demonstrate that long-term FED, with HSD, induces HTN with a sexual dimorphic effect, apparently through differential renal sodium handling.
P099 EXERCISE TRAINING FURTHER ATTENUATES BLOOD PRESSURE VARIABILITY AND RENAL DAMAGE IN HYDROCHLOROTHIAZIDE TREATED-HYPERTENSIVE AND POSTMENOPAUSAL RATS
Authors: Neves Pietra Petrica , Ferreira Maycon Junior , Shecaira Tânia Plens , Rascio Henriques Dutra Marina , Kimura Débora Conte , Gomes Guiomar Nascimento , Irigoyen Maria Claudia , De Angelis Katia 
Published: September 2024

Background and Objective:
Considering that blood pressure variability (BPV) has been associated with damage to target organs such as the kidney, this study aimed to investigate the effects of hydrochlorothiazide (HCTZ) combined with exercise training (CET) on BPV, as well as renal tissue morphology, function, inflammation, and oxidative stress.

Methods:
Female spontaneously hypertensive rats (SHR) were divided into 4 ovariectomized groups (n=5-6/group): sedentary (OS), sedentary + HCTZ (OSH), trained (OT), and trained + HCTZ (OTH). Both HCTZ (3 mg/kg) and CET (3 days/week) were administered for 8 weeks. Blood pressure was directly recorded for BPV analysis.

Results:
Renal function, morphology, inflammation and oxidative stress were assessed. The OSH, OT, and OTH groups had lower systolic BP (OSH: 189±13; OT: 179±5; OTH: 174±15 mmHg) compared to the OS group (208±15 mmHg). Only the combination of the drug with CET promoted a reduction in BPV variance. The HCTZ-treated groups showed lower plasma creatinine levels and increased creatinine clearance compared to the OS group. Treated groups showed a reduction in fields of 51–100% of interstitial tubule fibrosis when compared to the OS group; and the OTH group also showed reduction in fields in the range of 26–50% vs. other groups. The HCTZ-treated groups showed a reduction in protein oxidation. Renal catalase and IL10/TNF-alpha ratio were increased in the OTH group. Positive correlations were obtained between SBP variance and SBP (r=0.72), plasma creatinine (r=0.58), and levels of TNF-α (r=0.69), hydrogen peroxide (r=0.61), and protein oxidation (r=0.66) in renal tissue.

Conclusions:
Our results highlight the enhanced efficacy of the combination of HCTZ and CET compared to the use of either drug alone in the model studied. This combination effectively reduced BPV, resulting in beneficial changes in renal inflammatory and redox profiles, inducing morphological and functional benefits in hypertensive ovariectomized rats.
Financial support: FAPESP (2022/04050-1), CNPq, CAPES-PROSUP, UNINOVE.
P101 LEFT VENTRICULAR MASS INDEX (LVMI) IS UNLIKELY TO NORMALISE WITH TREATMENT USING CURRENTLY RECOMMENDED BLOOD PRESSURE TARGETS
Authors: Jedrzejewski Dawid , Lacy Peter , Williams Bryan 
Published: September 2024

Background and Objectives:
LVMI is one of the strongest predictors of cardiovascular events. However, it's unclear whether current blood pressure (BP) targets normalise LVMI relative to a truly normotensive population. We therefore compared achieved LVMI in a younger cohort of hypertensive patients (< 55 years) treated for one year to conventional blood pressure targets (< 140/90 mmHg) versus the LVMI of a truly normotensive age-matched healthy population from the UK Biobank (BP ≤ 120/80 mmHg).

Methods:
The normotensive cohort comprised 101 treatment-naïve men (mean ± SD age: 52 ± 2 years, BP: 112 ± 7/68 ± 7 mmHg) from 77,983 UK Biobank participants who had undergone cardiac Magnetic Resonance Imaging (cMRI) to determine LVMI. The treated hypertensive cohort comprised 44 men from the TREAT CASP study* (mean age: 49 ± 6 years) who achieved mean BP of 129 ± 10/78 ± 8 mmHg after one-year treatment. LVMI in both cohorts was measured accurately via automated analysis of cMRI and manually reviewed for accuracy.

Results:
LVMI in Biobank cohort was 51.3 ± 6.0 g.m-2 (95% CI: 50.1 to 52.4 g.m-2). In the hypertensive cohort, after one year of treatment, LVMI was reduced (59.2 ± 7.0 versus 56.0 ± 7.0 g.m-2, P <0.001) but remained higher than the Biobank cohort (56.0 ± 7.0 versus 51.3 ± 6.0 g.m-2, P <0.001). Mean LVMI of treated-hypertensive patients achieving truly normotensive BP (≤ 120/80 mmHg) was 52.7 ± 5.7 g.m-2 (95% CI: 48.9 to 56.4 g.m-2; n = 9).

Conclusions:
This study identified optimal cMRI LVMI for healthy middle-aged men. Antihypertensive treatment reduces but does not restore LVMI to normal levels, suggesting much lower BP targets than currently recommended are likely to be necessary to normalise LVMI in hypertensive patients.

*Reference:
Lacy, P. S., Jedrzejewski, D., McFarlane, E., & Williams, B. (2023). Blood pressure measurement modalities and indexed left ventricular mass in men with low-risk hypertension confirmed by ambulatory monitoring. Journal of Hypertension, 41(6), 941-950.
P109 AMINOPEPTIDASE A: A POTENTIAL NOVEL THERAPY FOR ANGIOTENSIN-DEPENDENT HYPERTENSION?
Authors: Forster Peter , Gonzalez Crisel Rivero , Mantilla Carlos Rueda , Wysocki Jan , Batlle Daniel 
Published: September 2024

Background:
We have shown that mice with a genetic deficiency in Aminopeptidase A (APA) have elevatedblood pressure. APA is an enzyme that removes a single aspartate residue from the amino-terminus of several peptides in the renin-angiotensin systems (RAS), including angiotensin (Ang) II. In this study, we investigated the impact of a recombinant APA on the cleavage of various RAS peptides and its effect on blood pressure.

Methods:
An in vitro assay was used to identify Ang peptides as substrates for APA. Ang peptides identified as APA substrates using this assay were then injected to anesthetized WT and APA-deficient mice to assess their pressor effect by measuring systolic blood pressure (SBP). Subsequently, murine recombinant (r)APA was used to evaluate its action on the acute SBP elevation elicited by Ang peptides that were identified to trigger pressor response.

Results:
In the in vitro assay, Ang II (22427±3353, n=12), Ang I (21883±1692, n=3), Ang1-7 (15833±3395,n=3), Ang1-9 (15773±3395, n=3) and Ang1-12 (13170±220, n=3), were identified as a substrate for rAPA as indicated by a strong aspartate-driven fluorescence formation. When these five Ang peptides were administered to WT mice, only Ang I, Ang II and Ang 1-12 caused a significant increase in SBP. This effect was exaggerated in APA deficient mice. The SBP increase elicited by Ang II in WT mice was markedly reduced by the pre-administration of rAPA (Fig).

Conclusion:
Aminopeptidase A can cleave the N-terminal aspartate from Ang II as well as from other RASpeptides that elicit (Ang 1-12, Ang I) and do not elicit (Ang 1-9, Ang 1-7) pressor response in mice. APA deficiency is associated with an exaggerated SBP response to Ang I, Ang II and Ang 1-12 while the recombinant enzyme mitigates the acute hypertensive effect. rAPA markedly reduced the increase in SBP caused by AngII infusion suggesting that it may be used to treat hypertension caused by excess of AngII.
P111 INTER-ARM DIFFERENCE IN SYSTOLIC BLOOD PRESSURE AMONG YOUNG POPULATION IN ABEOKUTA, NIGERIA
Authors: Adebayo Oladimeji , Ayowole Damilola , Inofomoh Francisca , Kanmodi Kehinde , Oiwoh Sebastine , Ojo Oluwaseyi , Williams Adedayo , Ibiyo Morohunmubo , Samuel Akinjopo , Ogunjimi Luqman 
Published: September 2024

Background and Objective:
Inter-arm blood pressure differences (IABPD) are linked to higher cardiovascular mortality and morbidity. Unfortunately, the profile and associated risk factors of IABPD in sub-Saharan Africa, particularly Nigeria are poorly studied. This study aims to determine the profile and associated correlates of systolic IABPD among the participants in the profile of anthropometry and psychosocial issues on campus (TERRACE) study, a cohort of young persons on selected tertiary educational campuses in Abeokuta metropolis aged 16-35years.

Methods:
This was a cross-sectional study. Basic demographic, anthropometric, and clinical data were collected. Brachial Blood Pressure (BP) were recorded in both arms, using validated electronic devices. Three standard measurements were performed on both arms. The IABPD was defined as the absolute value of the difference in systolic blood pressure(SBP) between the left and right arms of BP averages. Significant IABPD ≥10 mmHg. Data was analysed using Statistical Package for the Social Sciences (SPSS) version 23. The level of statistical significance was set at <0.05.

Results:
A total of 301 participants with age, 21.8±4.9 years and female proportion of 65.1%. The mean±SD of neck circumference, weight, height, right SBP, left SBP were 26.2 ± 3.6 cm, 58.0 ± 10.0 kg, 164.1 ± 10.4 cm, 112.9± 11.6mmHg and 112.0 ± 11.1 mmHg respectively. The median systolic IABPD was 0.6 mmHg, and the prevalence of significant systolic IABPD is 9.0% (11.4% in males and 7.7% in females, p- value: 0.275). Among our participants, there were 6.0%, 2.3% and 0.7% with a systolic IABPD in the ranges: 10-14.9mmHg, 15-19.9mmHg and ≥ 20mmHg respectively. The proportion with dominantly high right SBP was 54.4% in males compared to females (41.9%), p- value: 0.209. There was a correlation between height and IABPD (r2=0.177, p-value=0.002)

Conclusion:
Our study found that this young population have high IABPD, suggesting increased cardiovascular risk. Routine measurement in both arms is advised.
P113 CARDIOVASCULAR RISK FACTOR CONTROL IN HYPERTENSIVE PATIENTS WITH TYPE 2 DIABETES: A CROSS-SECTIONAL EPIDEMIOLOGICAL STUDY IN COLOMBIA (SNAPSHOT STUDY)
Authors: Quintero-Baiz Adalberto , Buelvas Herazo Jannes Jose , Gomez Jaime Orlando Ibarra , Etayo Ruiz Edwin Harbey , Jattin Fernando Gabriel Manzur , Tamayo Maya Juan Guillermo , Valiente Jose Mario Porto , Correa Luis Eduardo Echeverria , Barrios Gilberto Amed Castillo , Moreno Cortes Javier Alfredo , Gutierrez Tomasa Bermudez 
Published: September 2024

Background and objective:
Hypertension is the leading preventable cause of cardiovascular (CV) disease and frequently occurs with other risk factors such as elevated blood glucose and cholesterol. This study aimed to assess the control rates of blood pressure (BP), glycated haemoglobin (HbA1c), and LDL-cholesterol (LDL-C) according to CV risk in hypertensive patients with type 2 diabetes in Colombia.

Methods:
SNAPSHOT, a cross-sectional, observational, multicenter, epidemiological study, involved patients enrolled by 20 investigators (mostly cardiologists [75.0%] and internists [20.0%]) in Colombia. CV risk was assessed based on the European Society of Cardiology CV disease prevention 2021 (SCORE2&2-OP) guidelines.

Results:
The analysis set included 459 patients; mean age (SD) was 68.7 (10.5) years, most patients were female (58.0%), and overweight or obese (73.4%). Most patients (91.7%) had at least 1 comorbidity in addition to hypertension and type 2 diabetes, including dyslipidemia in 85.6% of patients.
Hypertension was treated in 97.6% of patients and considered by investigators to be controlled in 72.8% of patients, whereas only 44.4% of patients were controlled according to guidelines. Type 2 diabetes was treated in 92.2% of patients and controlled in 55.5% according to guidelines. In the subset of patients with concomitant dyslipidemia, LDL-C was treated in 95.2% and controlled according to guidelines in 25.6% of patients. The proportion of patients controlled for both hypertension and diabetes was 24.0% and the proportion controlled on all three parameters was 9.5% (Figure). Single-pill combinations were used to treat diabetes in 39.7%, hypertension in 21.4%, and dyslipidemia in 16.8% of patients. Mean (SD) systolic and diastolic BP were 131.3 (18.0) and 77.5 (10.1)mmHg, respectively; mean (SD) HbA1c was 7.0 (1.5)%; and mean (SD) LDL-C was 91.0 (43.4)mg/dL.

Conclusions:
This study showed a substantial unmet medical need: control rates for BP, HbA1c, and LDL-C in Colombia fell short among patients examined, emphasizing the urgency for enhanced therapeutic strategies.