bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venetoclax and azacitidine compared with intensive chemotherapy for adverse-risk acute myeloid leukemia patients receiving allogeneic hematopoietic stem cell transplantation in first complete remission: a multicenter study of TROPHY group.
Authors: Mo Xiaodong , Wen Qi , Jiang Chuanhe , Liu Xiaodan , Xia Yi , Ma Yilei , Yang Yang , Wang Yu , Chang Yingjun , Wang Luxiang , Zhang Zilu , Huang Xiaojun , Cao Yang , Zhao Yanmin , Hu Xiaoxia 
Published: October 2024

Abstract

It was commonly accepted that adverse-risk acute myeloid leukemia patients should receive allogeneic hematopoietic stem cell transplantation (allo-HSCT) in first complete remission (CR1). In this multicenter study, we aimed to compare the post-transplant outcomes between patients receiving venetoclax with azacitidine (VEN-AZA, n = 47) and intensive chemotherapy (IC, n = 264) before allo-HSCT. In total cohort, the 3-year probabilities of overall survival, leukemia-free survival, and event-free survival of IC group were all better than VEN-AZA group, particularly for the patients with ASXL1 mutation or with SF3B1 mutation. Even in the patients ≥ 55 years or those with HCT-CI ≥ 1 scores before allo-HSCT, the survival of VEN-AZA group was not superior to the IC group. After propensity score matching, the overall survival at 1 year after allo-HSCT for IC group was better than that of VEN-AZA group (93.6 vs. 78.0%, P = 0.034), and the other clinical outcomes were comparable between VEN-AZA and IC groups. TP53 mutation was the most important adverse prognostic factor for post-transplant relapse and survival. Thus, our results did not support the preferential use of VEN-AZA over IC regimens in young and medical fit adverse-risk AML patients who would receive allo-HSCT in CR1.
Antenatal Stress, marital satisfaction and antenatal depression of Chinese couples: An actor - partner interdependence model extended to mediation
Authors: Dong Yuting , Liu Xiaoqing , Xu Xingyan , Luo Jinying , Liu Shiqiong , Zeng Hang , Song Yang , Zhou Xiaowan , Li Huangyuan , Wu Siying , Lin Shaowei 
Published: October 2024

Abstract

Background
Pregnant women exhibit heightened vulnerability to stress and an elevated risk of depression during gestation. Antenatal depression increases the likelihood of adverse outcomes, including postpartum depression. Current research often overlooks the spouse's role, focusing solely on the pregnant woman.
Aims
To explore couple-based antenatal stress interactions on depression and the mediating role of marital satisfaction.
Methods
Convenience sampling method was used to select 244 couples attending Maternal and Child Health Hospital of Fujian province as the study subiects. The path relationships between antenatal stress, marital quality and antenatal depression of couples were analysed by APIMeM.
Results
Individual antenatal stress exerts a direct effect on antenatal depression, both within the individual and in their spouse. Furthermore, marital satisfaction mediated the actor effect of antenatal stress and depression in wives, as well as the partner effect of antenatal stress in husbands on their wives’ antenatal depression.
Conclusion
Antenatal emotions exhibit cross-partner effects, and the marital satisfaction may serve as a potential mediating factor in the relationship between antenatal stress and antenatal depression. Couples are encouraged to prioritize stress management during pregnancy, enhancing marital satisfaction can mitigate the harmful effects of antenatal stress on depression, potentially improving pregnancy outcomes and postnatal health.
LncRNA LFQR promotes cytoactivity and resistance to quizartinib via FLT3 transcriptional activation in FLT3-ITD acute myeloid leukemia
Authors: Tang Yan-Lai , Liu Ying-Li , Zhang Xiao-li , Luo Xue-Qun , Sun Yu-Meng , Lian Jun-Yi , Song Shi-Yao , Ke Zhi-Yong , Wang Li-Na , Liang Cong , Fan Zhong , Huang Li-bin , Wang Wen-Tao 
Published: October 2024

Abstract

FMS-like tyrosine kinase-3 internal tandem duplication (FLT3-ITD) acute myeloid leukemia (AML) is an adverse subtype of leukemia associated with a poor patient prognosis. FLT3 inhibitors exhibit promising clinical activity, however, their effectiveness is limited by drug resistance. Therefore, overcoming resistance to FLT3 inhibitors remains an important clinical problem, necessitating the development of new strategies. In this study, we identified a lncRNA, AL713998.1, which was upregulated in both FLT3-ITD AML and quizartinib-resistant cells (LFQR). In vitro experiments showed that LFQR silencing significantly inhibited cell proliferation, impaired self-renewal capacity, caused cell cycle arrest and induced cell differentiation, specifically in FLT3-ITD AML. In addition, the interaction of LFQR with SFPQ was verified using RNA pull-down assays, mass spectrometry and RNA immunoprecipitation. Mechanistically, LFQR promotes SFPQ binding to the promoter region of FLT3 and facilitates transcriptional regulation, thereby increasing the expression of kinase and oncoproteins in FLT3-ITD AML cells. Notably, LFQR inhibition also impaired the cytoactivity of quizartinib cells and reversed their resistance to quizartinib. Overall, our study highlights that LFQR may serve as a potential therapeutic target in FLT3-ITD AML, and its knockdown can significantly improve the efficacy of quizartinib, thus providing a promising strategy for overcoming resistance to FLT3 inhibitors.
Longitudinal Impact of Metabolic Syndrome Evolution on Incident Chronic Disease Multimorbidity: A Cohort Study
Authors: Wang Yuxian , Chen Zekai , Qin Hailun , Fu Peng , Huo Zhenyu , Wu Kuangyi , Zheng Huancong , Cai Zefeng , Wu Weiqiang , Lan Yulong , He Zhen , Wu Shouling , Chen Youren 
Published: October 2024

Abstract

Background
Metabolic syndrome (MetS) has been associated with the development of chronic diseases, including cardiovascular disease (CVD), type 2 diabetes (T2D), and chronic kidney disease (CKD). However, the association of a longitudinal MetS evolution with the multimorbidity of these disease remains unclear. We aimed to investigate the impact of MetS evolution on incident chronic disease multimorbidity.
Methods
This prospective cohort study included 36,201 participants in the Kailuan cohort who were free of CVD, CKD, T2D before 2006–2010. MetS patterns was categorized according to the status of MetS obtained during the 2006 and 2010 surveys. The primary endpoint was chronic disease multimorbidity (suffering from at least 2 of CKD, CVD and DM), and secondary endpoints included CVD-T2D multimorbidity, CVD-CKD multimorbidity and T2D-CKD multimorbidity. Cox regression models were used to assess the association of MetS evolution with chronic disease multimorbidity and its components.
Results
During a median follow-up of 12.02 years, 930 participants developed chronic disease multimorbidity. After considering potential confounders, the persistent metabolic disorder group (hazard ratio [HR], 2.95 [95% CI, 2.41–3.60]), the MetS recovery group (HR, 1.87 [95% CI, 1.48–2.36]), and the MetS progression group (HR, 1.70 [95% CI, 1.39–2.06]) were all associated with an elevated risk of chronic disease multimorbidity compare with the sustained metabolic health group. Generally similar results were observed in CVD-T2D multimorbidity, CVD-CKD multimorbidity and T2D-CKD multimorbidity, and the analysis of single diseases complements our conclusions.
Conclusions
Not only the current presence of MetS, but also a history of metabolic disorders, even in the absence of current MetS, may increase the risk of chronic disease multimorbidity. The findings emphasize the need for primary prevention of MetS and intervention in individuals with a history of MetS in order to halt further progression to chronic disease and the multimorbidity.
Efficacy and safety of anlotinib combined with chemotherapy plus anlotinib maintenance in Radioiodine-refractory differentiated thyroid cancer: a case report and literature review
Authors: Zhou Chun-yan , Li Huan-huan , Lan Xin , Pan Xiao-mei , Song Feng-ping , Duan Dong 
Published: October 2024

Abstract

Background: Radioiodine-refractory differentiated thyroid cancer is one of the leading causes of mortality among patients with thyroid cancer, presenting significant clinical challenges in both diagnosis and management. In addition to sorafenib and levatinib, China's self-developed tyrosine kinase inhibitor, anlotinib, has been approved by the national medical products administration for the treatment of progressive, locally advanced or metastatic radioiodine-refractory differentiated thyroid cancer. Despite the potential of single-agent therapy to improve treatment efficacy, the management of patients with advanced radioiodine-refractory differentiated thyroid cancer who have exhausted first- and second-line treatments remains a considerable challenge, with limited chances of achieving satisfactory outcomes. Recent research has shown that anlotinib combined with chemotherapy has an enhanced antitumor efficacy and a tolerable safety profile in patients with triple-negative breast cancer and advanced ovarian cancer. However, the efficacy and safety of anlotinib with chemotherapy for radioiodine-refractory differentiated thyroid cancer have not been reported in the literature.
Case presentation: Here, we present a case of metastatic radioiodine-refractory differentiated thyroid cancer that was treated with a combination of anlotinib and chemotherapy, along with anlotinib maintenance therapy after the failure of sorafenib treatment, resulting in favorable outcomes.
Conclusions: The combination of anlotinib and chemotherapy, followed by anlotinib maintenance, showed promising efficacy and manageable toxicity in the treatment of advanced radioiodine-refractory differentiated thyroid cancer.
Challenges Management of Patients with Oral Cancer and Its Impact on Oral health‑related quality of life in Resource-limited Settings
Authors: bushabu Fidele Nyimi , kapamona Panumvita , Lubamba Grace Paka , David Kayembe Mwimbi , Kazadi Em Kalala , Milolo Augustin Mantshumba , Ingenya Edize Ekofo , Mwinaminayi Pierre Muyembi 
Published: October 2024

Abstract

Purpose
the purpose of the present study was to identify the challenges in the management of patients with OC in resource-limited settings, and to evaluate their quality of life in this area.
Material and methods
A cohort random study of Congolese participants was conducted using a clinical questionnaire and an Oral Health Impact Profile (OHIP)‑14 questionnaire between the OC patient and control groups. Predictor variable was the treatment method, clinical characteristics and the main outcome variable(s) were the challenges or quality of life. The Chi‑square test was used to compare the percentage of qualitatively dependent variables, independent sample t‑test and ANOVA to compare OHIP score. Statistical significance was set at 5%.
Results
Out of 457 patients, 66% were male, and 34% female.More than fifty percent of patients were unemployed. Observation therapy and traditional medicine were done in 29.8% and 25.4%. More than sixty percent of patients reported delays in initiating cancer treatment and 78% of participants could not inform other persons because of the conception of oral cancer diseases. The patients with OC were affected by the quality of life even with or without the treatment done.
Conclusion:
Challenges management of oral cancer in resource-limited settings result in several factors. This mostly are the result of the poor socioeconomic status of the patients and the conception of oral cancer diseases in the region. With or without treatment, the patients were affected in their quality of life.
Estimation of Central Venous Pressure Using Cardiac Ultrasound of Inferior Vena Cava in Ventilated Children: A Prospective Multicenter Observational Study
Authors: Sée Perrine , Hayotte Aurélie , Roux Enora Le , Guilbert Anne-Sophie , Collignon Charlotte , Denante Solene , Klifa Roman , Rambaud Jérome , Brissaud Olivier , Dauger Stéphane 
Published: October 2024

Abstract

Background:
Although ultrasound (US) parameters of the inferior vena cava (IVC) cannot be used to estimate central venous pressure (CVP) in adults under mechanical ventilation (MV), the limited pediatric literature reports highly contradictory results. Pediatric evidence was awaited.
Methods:
This prospective, multicenter, observational study, conducted in six pediatric intensive care units, included children aged 2 days to 12 years who were under MV and had a central venous catheter in the superior vena cava to monitor CVP. US measurements were performed by experienced intensivists in order to calculate the following parameters: i) IVC-Collapsibility: [(IVCdmax - IVCdmin)/IVCdmax] x 100, ii) IVC-Distensibility: [(IVCdmax - IVCdmin)/IVCdmin] x 100, iii) IVC/Aortic: (IVCdmax/Ao) x 100. The search for correlation was studied using scatter plot and Pearson and Spearman's correlation tests for linear and monotonic relationships, respectively.
Results:
We included 120 children with a median age of 11.5 [2.0; 46.3] months and a median weight of 9.0 [5.0 ;15.0] kg. A third of the patients were admitted for post-operative care, including cardiac surgery, and a fourth for respiratory failure, with a median CVP of 7.5 [5.0; 10.3] mmHg at inclusion. No significant relationship was found between CVP and IVC-Collapsibility (Pearson r = -0.05, p = 0.55; Spearman r = -0.09, p = 0.32), IVC/Ao (Pearson r = 0.16, p = 0.08; Spearman r = 0.17, p = 0.06), or IVC-Distensibility (Pearson r = -0.003, p = 0.97; Spearman r = -0.09, p = 0.29).
Conclusion:
There is no correlation between CVP and IVC-US parameters in children under MV.
Adjunctive diagnostic tool for histopathological classification in congenital mesoblastic nephroma
Authors: Hamada Hiroshi , Kohashi Kenichi , Iwasaki Takeshi , Hashisako Mikiko , Hino Yuko , Fukuhara Masahiro , Kamouchi Amane , Kawakubo Naonori , Tajiri Tatsuro , Oda Yoshinao 
Published: October 2024

Abstract

Purpose: Congenital mesoblastic nephromas (CMN) are histologically classified into classical, cellular, and mixed subtypes. Most cellular CMNs harbor ETV6-NTRK3 gene fusions, and classic and mixed CMNs harbor EGFR internal tandem duplications (EGFR-ITDs). Classic CMNs are considered benign, whereas recurrent or metastatic diseases occur in the cellular subtypes. Direct identification of mutations is desirable for an accurate diagnosis. However, molecular genetic analyses cannot be performed in a number of histopathology laboratories. This study aimed to investigate a surrogate marker for the accurate histological classification of CMN.
Methods: Overall, 11 CMN cases diagnosed at our institute were included in this study. Reverse transcription-polymerase chain reaction was performed for the NTRKgene fusion and EGFR-ITDs in all cases. Comprehensive mRNA analysis was performed using the nCounter® Gene Expression Assay. Principal component analysis (PCA) was performed based on the gene expression levels. Immunohistochemical evaluation was conducted for the expression of p-Mek1/2, p-Erk1/2, and EGFR.
Results: PCA revealed differences in mutation patterns between the EGFR-ITDs and NTRKfusion tumor groups. Gene ontology analysis of the highly expressed genes in the EGFR-ITDstumor group revealed enrichment related to the mitogen-activated protein kinase (MAPK) signaling pathway. p-Mek1/2 and p-Erk1/2 immunoreactivity was significantly increased in the EGFR-ITDs tumor group (p = 0.018 and p = 0.017, respectively). EGFR immunoreactivity is not a useful marker for CMN with EGFR-ITD.
Conclusion: p-Mek1/2 and p-Erk1/2 immunoreactivity may be useful markers for EGFR-ITDs. Thus, MEK1/2 inhibitors possess the potential to be used as a targeted therapy for CMN with EGFR-ITDs.
Can Robots Keep You Upright?: An Ergonomic Analysis of Surgeon Posture in Robotic versus Conventional Total Knee Arthroplasty
Authors: Gapinski Zachary , Mason Eric , Kothari Ezan , Desai Pratik , Haidukewych George , Green Cody 
Published: October 2024

Abstract

Background
Robotic-assisted technology has become an increasingly utilized adjunct within the realm of primary total knee arthroplasty (TKA). Previous studies have shown that robotic-assisted total knee arthroplasty (raTKA) offers potential advantages of enhanced bony preparation and optimal implant alignment with equivalent long-term patient outcomes and component longevity in comparison to conventional TKA (cTKA). Furthermore, recent studies have identified the additional benefit of decreased surgeon physiologic stress with the use of raTKA. The purpose of this study was to compare differences in surgeon posture between primary raTKA and cTKA.
Materials and Methods
We prospectively evaluated 103 consecutive primary TKA cases (48 raTKAs, 55 cTKAs) performed by three high-volume, fellowship-trained arthroplasty surgeons. Throughout each case, surgeons wore a posture-tracking device to evaluate time spent slouching. The threshold for slouching was set to 30 degrees of flexion from a neutral spinal axis. Demographic and operative factors were collected. Two tailed tests and multivariate analysis were used to assess for differences between groups.
Results
After controlling for individual surgeon differences in posture, we found a decrease in percentage and duration of time spent slouching in raTKA cases compared to cTKA cases (42.4 vs 72.5%, P < 0.001, 35.4 vs 54.7 min, P = 0.037). On average, use of the robot decreased surgeon slouching time by 19.3 min (26.6%, p < 0.001). Patient factors such as increased age and ASA 2 were also associated with favorable effects on posture (p < 0.001).
Conclusions
Surgeons performing primary raTKA cases spend significantly less case time and case percentage in a slouched posture compared to conventional primary TKA cases. This suggests potential for ergonomic benefit of robotic-assisted technology in primary TKA. Further research is needed to determine the long-term effects of posture on surgeon pain and career longevity.
Analysis of the Relationship Between the Characteristics of the Blood Internal Environment and Early Prognosis in Patients with Cardiac Arrest
Authors: Wang Yuwei , Wang Meiling , Yan Danping , Liu Yajie , Zhou Shuaishuai , Fang Jue , Zhan Fenfang , Wang Sa 
Published: October 2024

Abstract

Background：Cardiac arrest is a highly time-dependent condition, and there is limited evidence regarding the relationship between changes in the blood internal environment before and after arrest and resuscitation and the return of spontaneous circulation (ROSC) in patients. This study aims to understand the dynamic changes in the internal environment of blood at different time points and to identify blood biomarkers for patients who achieve ROSC.
Methods：A retrospective analysis was conducted on patients with CA in a tertiary hospital in China from January 2021 to December 2023. The study described and compared laboratory blood indicators at different time points: prior to cardiac arrest, during resuscitation, and after ROSC. Multivariate logistic regression analysis was employed to identify independent influencing factors for ROSC, and receiver operating characteristic (ROC) curves were plotted to evaluate their predictive value.
Result Among the 270 patients included in the final analysis, 122 achieved ROSC. Compared to pre-arrest and post-ROSC levels, WBC count, neutrophils, pH, and PO2 were lower during resuscitation, while lymphocytes, potassium, and PCO2 were higher (P < 0.05). In further comparison to the non-ROSC group, the ROSC group had higher WBC count, neutrophils, lymphocytes, platelets, and PO2 during resuscitation, but lower INR, D-dimer, and BE. WBC, D-dimer, and PO2 were identified as independent influencing factors for ROSC in cardiac arrest patients, with AUC of 0.686, 0.374, and 0.775. The combined detection of these three factors yielded an AUC of 0.826, with a sensitivity of 71.2% and specificity of 85.2%.
Conclusion：The different stages of CA and resuscitation exhibit distinct characteristics in the internal environment of blood. Factors such as WBC, neutrophils, and PO2 are significant influencing factors for ROSC in CA patients.
Effectiveness of self-care supported motivational interview to increase self-care agency and disease adaptation levels of hemodialysis patients: A randomized controlled trial
Authors: gerçek abdullah , KILIÇ Phd SERAP PARLAR 
Published: October 2024

Abstract

Background
This study aimed to determine the effect of self-care-supported motivational interview on the self-care and disease adaptation of patients with hemodialysis treatment. Self-care training supported by motivational interviewing affects both patients' self-care and adaptation to the disease.
Methods
The research was conducted between October 2020 and March 2021 in the Hemodialysis Unit of a state hospital in a province in the east of Turkey. 77 hemodialysis patients participated in this study conducted with randomized controlled research pattern. Personal Information Form, Adaptation to Chronic Illness Scale and Self Care Agency Scale were used in the collection of data.
Results
It was found that the average score in the experimental and control groups was similar prior to, and the score averages of the experimental group increased significantly after compared to those of the control group. In-group comparisons revealed that the difference between pre-test, post-test and follow-up test mean scores of patients in the experimental group and their mean scores has changed significantly. Pre-test, post-test and follow-up test total scores, physical scores and social scores of the patients in the control group showed significant differences.
Conclusions
In order to increase patients' adaptation to chronic diseases and their self-care power, self-care supported motivational interviewing technique should be applied to patients. In order to increase the health level of patients, nurses should use the self-care supported motivational interviewing technique during care practices.