bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of behavioral reasoning theory to examine the role of social responsibility in attitudes toward apparel donation
Authors: Park MinJung , Cho Hyojung , Johnson Kim K. P. , Yurchisin Jennifer 
Published: February 2017

AbstractDrawing on behavioral reasoning theory, this study investigated drivers of young consumers’ apparel donation behavior. By examining the impact of values (i.e., benevolence and power) and reasons (i.e., other‐oriented reasons and self‐oriented reasons) on attitudes, this study highlights the different motivations individuals have for donating clothing. As predicted, benevolence was positively related to other‐oriented reasons for donations and power was positively related to self‐oriented reasons for donations. Both other‐ and self‐oriented reasons for donating influenced attitudes related to apparel donation behavior. These findings offer an overarching explanation for the seemingly disparate reasons for apparel donation previously identified.
Laparoscopic implantation of artificial urinary sphincter in women with intrinsic sphincter deficiency: Mid‐term outcomes
Authors: Ferreira Carlos , Brychaert Pierre‐Emannuel , Menard Johann , Mandron Eric 
Published: February 2017

ObjectivesTo analyze the safety and the mid‐term continence rates of laparoscopic implantation of artificial urinary sphincter in women.MethodsA total of 52 women with intrinsic sphincter deficiency underwent a laparoscopic artificial urinary sphincter implantation from 2005 to 2015 at Surgical Clinic Du Pré, Le Mans, France. The artificial urinary sphincter was implanted around the bladder neck by a transperitoneal laparoscopic approach to the Retzius space. Urodynamic assessment was carried out. Postoperative functional outcome was defined as success (no leaking, no pad use), improvement (>50% decrease in number of leakages, >50% decrease in number of pads used or use of light protection) or failure (<50% improvement, persistent or increased leaking). Outcome measures also included perioperative and long‐term complications.ResultsThe mean age of the patients was 69.1 years (range 64–82 years). After a mean follow up of 37.5 months (median 24 months; range 1–125 months), 38 (77.6%) patients were considered to be continent (no leakage, no pads), and eight (16.3%) improved their grade of incontinence. Three patients abandoned the follow‐up schedule and were excluded. There was no perioperative severe complication. Artificial urinary sphincter revision was needed in 11 (22.4%) patients, requiring a total of seven redo procedures and four permanent sphincter removals. The main reasons for redo procedures were six (11.2%) mechanical problems and one vaginal erosion (2%).ConclusionsHerein we report one of the largest series with the longest follow up evaluating the outcomes of laparoscopic artificial urinary sphincter implantation in female patients. This approach seems to be a safe and effective treatment option for patients with intrinsic sphincter deficiency.
(Pro)renin receptor (ATP6AP2) depletion arrests As4.1 cells in the G0/G1 phase thereby increasing formation of primary cilia
Authors: Wanka Heike , Lutze Philipp , Staar Doreen , Peters Barbara , Morch Anica , Vogel Lukas , Chilukoti Ravi Kumar , Homuth Georg , Sczodrok Jaroslaw , Bäumgen Inga , Peters Jörg 
Published: February 2017

AbstractThe (pro)renin receptor [(P)RR, ATP6AP2] is a multifunctional transmembrane protein that activates local renin–angiotensin systems, but also interacts with Wnt pathways and vacuolar H+‐ATPase (V‐ATPase) during organogenesis. The aim of this study was to characterize the role of ATP6AP2 in the cell cycle in more detail.ATP6AP2down‐regulation by siRNA in renal As4.1 cells resulted in a reduction in the rate of proliferation and a G0/G1 phase cell cycle arrest. We identified a number of novel target genes downstream ofATP6AP2knock‐down that were related to the primary cilium (Bbs‐1, Bbs‐3, Bbs‐7, Rabl5, Ttc26, Mks‐11, Mks‐5, Mks‐2, Tctn2, Nme7) and the cell cycle (Pierce1, Clock, Ppif). Accordingly, the number of cells expressing the primary cilium was markedly increased. We found no indication that these effects were dependent of V‐ATPase activity, asATP6AP2knock‐down did not affect lysosomal pH and bafilomycin A neither influenced the ciliary expression pattern nor the percentage of ciliated cells. Furthermore, ATP6AP2 appears to be essential for mitosis. ATP6AP2 translocated from the endoplasmatic reticulum to mitotic spindle poles (pro‐, meta‐ and anaphase) and the central spindle bundle (telophase) andATP6AP2knock‐down results in markedly deformed spindles. We conclude that ATP6AP2 is necessary for cell division, cell cycle progression and mitosis. ATP6AP2 also inhibits ciliogenesis, thus promoting proliferation and preventing differentiation.
Filaggrin loss‐of‐function mutations, atopic dermatitis and risk of actinic keratosis: results from two cross‐sectional studies
Authors: Andersen Y.M.F. , Egeberg A. , Balslev E. , Jørgensen C.L.T. , Szecsi P.B. , Stender S. , Kaae J. , Linneberg A. , Gislason G. , Skov L. , Elias P.M. , Thyssen J.P. 
Published: February 2017

AbstractBackgroundCommon loss‐of‐function mutations in filaggrin gene (FLG) represent a strong genetic risk factor for atopic dermatitis (AD). Homozygous mutation carriers typically display ichthyosis vulgaris (IV) and many have concomitant AD. Previously, homozygous, but not heterozygous, filaggrin gene mutations have been associated with squamous cell carcinomas.ObjectiveThe first objective was to examine the association between FLG mutations and actinic keratosis (AK). The second objective was to investigate the occurrence of AK in patients with IV and AD, respectively.MethodsFLG mutation status in patients with AK was compared with controls from the general population. Furthermore, based on nationwide data from Danish registers, we compared the risk of AK in patients with IV, AD and psoriasis, respectively.ResultsThe prevalence of homozygous FLG mutations was significantly higher in the AK group (n = 4, 0.8%) in comparison with the control group (n = 18, 0.2%), whereas the prevalence of heterozygous FLG mutations was lower. In hospital registry data, patients with AD exhibited an increased risk of AK than did psoriasis controls (adjusted OR 1.46; [95% CI 1.12–1.90]), whereas no difference in risk was observed between patients with IV and AD.ConclusionsThis study indicates an increased susceptibility to AK in individuals with homozygous, but not heterozygous, FLG mutations and in patients with AD compared to psoriasis. Whether a reduction or absence of epidermal filaggrin could contribute to the susceptibility to AK in patients with IV and AD is unknown and additional research is needed to further explore this relationship.
The risk of depression, suicidal ideation and suicide attempt in patients with psoriasis, psoriatic arthritis or ankylosing spondylitis
Authors: Wu J.J. , Penfold R.B. , Primatesta P. , Fox T.K. , Stewart C. , Reddy S.P. , Egeberg A. , Liu J. , Simon G. 
Published: February 2017

AbstractBackgroundSparse information is available concerning mental health issues in psoriasis, psoriatic arthritis (PsA) and ankylosing spondylitis (AS) patients.ObjectiveTo estimate risk of depression, suicidal ideation and suicide attempt in patients with psoriasis, PsA and AS, respectively, compared with the general population.MethodsThis population‐based cohort study analysed 36 214 psoriasis patients, 5138 PsA patients and 1878 AS patients who were frequency‐matched with a general population cohort. Annual incidence rate of depression, suicidal ideation and suicide attempt was calculated separately for psoriasis, PsA and AS.ResultsThere was an increased risk of depression in the three cohorts; adjusted IRR: psoriasis, 1.14 (95% CI, 1.11, 1.17); PsA, 1.22 (95% CI, 1.16, 1.29); AS, 1.34 (95% CI, 1.23, 1.47). There was no significantly increased risk for suicidal ideations or suicide attempt among psoriasis, PsA or AS patients.LimitationsPatients were not excluded if previously diagnosed with depression, suicidal ideation or suicide attempt. Suicide attempt and completed suicide analyses were not adjusted for presence of depression. Use of systemic psoriasis treatment to measure severe psoriasis could lead to psoriasis severity misclassification.ConclusionThe risk of depression, but not suicidal ideation or suicide attempt, was significantly increased in patients with psoriasis, PsA and AS.
Firm Age, Investment Opportunities, and Job Creation
Authors: ADELINO MANUEL , MA SONG , ROBINSON DAVID 
Published: February 2017

ABSTRACTNew firms are an important source of job creation, but the underlying economic mechanisms for why this is so are not well understood. Using an identification strategy that links shocks to local income to job creation in the nontradable sector, we ask whether job creation arises more through new firm creation or through the expansion of existing firms. We find that new firms account for the bulk of net employment creation in response to local investment opportunities. We also find significant gross job creation and destruction by existing firms, suggesting that positive local shocks accelerate churn.
Skeletal and dental effects of Class III orthopaedic treatment: a systematic review and meta‐analysis
Authors: Rongo R. , D'Antò V. , Bucci R. , Polito I. , Martina R. , Michelotti A. 
Published: February 2017

SummaryTo summarise the skeletal, dental and soft tissue effects of orthopaedic treatment on growing skeletal class III patients compared with a concurrent untreated similar control group and to evaluate whether the design of the primary studies may affect the results. A literature search was performed up to the end of February 2016. No restrictions were applied concerning language and appliances. Once the quality score was assessed, a meta‐analysis was performed for the appliances used in more than three studies. A moderator analysis for study design was performed. The level of evidence was evaluated by means of the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) tool. The search resulted in 21 papers. The quality of most of the studies was medium. Each study reported skeletal sagittal improvement and overjet correction. Fourteen studies reported a significant increase in lower facial height. Follow‐up data showed slight relapses in about 15% of patients. Meta‐analyses were performed for the facemask and chin cup. The two appliances were efficient for correcting the sagittal discrepancy, increasing the divergence. In the analysis for study design, the retrospective studies showed a more efficient appliance than RCTs for 6 of 13 variables. The level of evidence was between very low and moderate. There is very low to low evidence that orthopaedic treatment is effective in the correction of Class III skeletal discrepancies and moderate evidence for the correction of the overjet. A common side effect is mandibular clockwise rotation in older subjects.
Grief, Death, and Longing in Stoic and Christian Ethics
Authors: Scherz Paul 
Published: February 2017

AbstractThe Stoic rejection of the passion of grief strikes many ethicists writing on dying as inhuman, selfish, or lacking appreciation for the world. This essay argues that Stoics rejected grief and the fear of death because these passions alienated one from the present through sorrow or anxiety for the future, disrupting one's ability to fulfill obligations of care for others and to feel gratitude for the gift of loved ones. Early Christian writers on death, such as Ambrose, maintained much of the substance of Stoic doctrine but transformed it through their belief in the resurrection and their corresponding revaluation of the future. While these writers rejected grief as an affective response to death, they affirmed longing for lost loved ones. These authors provide an example of how contemporary religious ethicists can use Stoic insights for recovering the tradition of the art of dying.
Can Isaac Forgive Abraham?
Authors: Gauvin Mitchell J. 
Published: February 2017

AbstractForgiveness is an expression that befits agents who are at heart morally frail and imperfect. There is strong disagreement regarding its structure, conditions, and permissibility. Søren Kierkegaard's pseudonymously authored Fear and Trembling—already well understood as a challenge to our understanding of faith, religion, and the moral law through its focus on the biblical tale of Abraham's binding of Isaac—offers an indirect challenge to our understanding of forgiveness. Isaac is too often overlooked as characterless and philosophically uninteresting. What such a reading ignores is his potential expression for what Kierkegaard understood as forgiveness: a dutiful commitment to love equally. Rather than dispelling traditional accounts of forgiveness, Isaac's binding reveals the extent of its diverse expressions.
Christian Supersessionism, Zionism, and the Contemporary Scene
Authors: Magid Shaul 
Published: February 2017

AbstractPostliberal theology has been a topic of considerable theological debate over the past few decades. In his 2011 book Another Reformation, Peter Ochs deploys a postliberal theological model for the purpose of developing a sophisticated understanding of the future of interreligious relations. Ochs argues that postliberal theology is a reparative theology focusing on alleviating human suffering. He argues that the Christian idea of supersessionism may be the most challenging for Christians to confront as they explore avenues for making interreligious dialogue more effective. Ochs critiques the Mennonite theologian John Howard Yoder's understanding of Zionism as Jewish Constantianism for being an instance of an ostensibly postliberal theology losing its way. In this essay, I offer a critique of Ochs's reading of Yoder, claiming that Yoder's view actually mirrors an important intra‐Jewish debate about the relationship between political power and piety, and retrieves an ingenious contribution of both early Judaism and early Christianity that is effaced in today's growing Constantinian approach to Christian imperialism and Jewish nationalism.
A Hermeneutics of Intimacy
Authors: Wesselhoeft Kirsten 
Published: February 2017

AbstractAll four of the volumes discussed here integrate erudite historical and textual scholarship in Islamic studies with clearly articulated ethical and theological projects of gender justice, which are in turn rooted in the authors’ engagements in Muslim communities worldwide. This combination is a hallmark of recent work on gender and sexuality in Islamic contexts, where scholars foreground the complex intersection of their own ethical standpoints, their historically and linguistically grounded exegesis of classical sources, and their hopes for gender justice in contemporary Muslim communities. In the process, they offer a range of evocative models for how to combine descriptive and constructive work in religious ethics. Further, this cluster of works contributes to an ongoing conversation in religious ethics about the concept of tradition. This review draws out a focus on the relational intimacy of the hermeneutical project that I argue constitutes an overarching theoretical intervention in the concept of an ethical tradition.
One Good Turn Deserves Another
Authors: Barbieri William A. 
Published: February 2017

AbstractElizabeth Bucar has provided a service to the guild with her introduction to the emergent field of visual ethics. In this comment I undertake to expand the picture she presents. I argue that the visual dimension of ethics includes a “dark side” not addressed in her piece, and go on to consider a number of current avenues of inquiry in which religious ethics intersects with visual studies. After briefly considering some of the distinctive methodological challenges attending the visual turn in ethics, I conclude my survey of this new field with some comments on the moral qualities of cinema.
Antibiotic administration alleviates the aggravating effect of orthodontic force on ligature‐induced experimental periodontitis bone loss in mice
Authors: Shi J. , Liu Z. , Kawai T. , Zhou Y. , Han X. 
Published: February 2017

Background and ObjectivesIt is recognized that orthodontic force (OF) has an aggravating effect on the progression of destructive periodontitis if periodontitis have not been well controlled. However, the underlying mechanism is not completely clear. This study was to investigate the effect of antibiotic administration on OF‐aggravated, ligature‐induced experimental periodontitis in mice.Material and MethodsC57BL/6 mice (male, 8 wk old) were divided into three groups (n = 8). Silk ligatures (SL) were tied around the maxillary right (group 1) or both (groups 2 and 3) first molars on day 0, removed on day 8 and systemic antibiotics was administered through drinking water (group 3) since day 8. OF was applied on the maxillary right first molars since day 13 (groups 2 and 3). All mice were killed on day 20.ResultsTotal oral bacteria load was significantly higher in group 2 when compared to group 1 on day 20, whereas such count was greatly reduced in group 3 when antibiotics were administered. Periodontal bone loss was significantly increased on SL side vs. control side in group 1. Periodontal bone loss was significantly increased on OF + SL side vs. SL side in group 2 (p < 0.05) but not in group 3 when systemic antibiotics were administered. Gingival mRNA and protein expressions of receptor activator of nuclear factor kappa‐B ligand/osteoprotegerin were significantly increased on OF + SL side vs. SL side in group 2 (p < 0.01) but not in group 3. However, comparable levels of tartrate‐resistant acid phosphatase‐positive cell formation within periodontal space and tooth movement were observed on OF + SL side in groups 2 and 3.ConclusionOur results suggest that reduction of oral bacterial load by antibiotic administration alleviate orthodontic force‐aggravated periodontitis bone loss.
The extrusion test and sensory perception revisited: Some comments on generality and the effect of measurement temperature
Authors: Brenner Tom , Tomczyńska‐Mleko Marta , Mleko Stanisław , Nishinari Katsuyoshi 
Published: February 2017

AbstractRelations between sensory perception, extrusion and fracture in shear, extension and compression are examined. Gelatin‐based gels are perceived as less firm and less hard than expected based on their mechanical properties compared to polysaccharide gels that have the same mechanical properties at room temperature but melt well above body temperature, underlying the importance of the measurement temperature for gels that melt during mastication. Correlations between parameters from extrusion and compression, extension and shear are verified using mixed polysaccharide gels.Practical applicationsWe previously reported a high correlation between several sensory attributes and parameters from an extrusion test. The extrusion test showed the most robust correlation, and could be used to assess samples at both extremes of the texture range with respect to elasticity, for example, both samples that could not be extended as their very low elasticity led to their fracture during handling, as well as samples that could not be fractured in compression. Here, we reexamine the validity of the relations reported. We demonstrate the generality of the relations between large deformation tests and extrusion, but the findings underscore the need to take into account the measurement temperature for samples that melt during mastication when correlating instrumental parameters with sensory perception.
Association of Hypercalcemia Before Treatment With Hypocalcemia After Treatment in Dogs With Primary Hyperparathyroidism
Authors: Dear J.D. , Kass P.H. , Della Maggiore A.M. , Feldman E.C. 
Published: February 2017

BackgroundDevelopment of hypocalcemia after treatment of hyperparathyroidism results in increased costs and risk of poorer outcomes. Previous studies have shown conflicting data about predictors of hypocalcemia after these procedures.Hypothesis/ObjectivesThe objective of this study was to investigate whether ionized calcium (iCa) concentrations before treatment are predictive of hypocalcemia or its clinical signs after surgical removal or heat ablation in dogs with primary hyperparathyroidism.AnimalsFifty‐four dogs with primary hyperparathyroidism (29 female, 25 male; 49 retrospective, 5 prospective).MethodsDogs were enrolled if they met the inclusion criteria: persistent hypercalcemia (iCa >1.41 mmol/L) due to primary hyperparathyroidism and absence of preemptive calcitriol treatment. All dogs were treated with parathyroidectomy (n = 37) or percutaneous ultrasound‐guided heat ablation (n = 17). After treatment,iCa was monitored twice daily until plateau or intervention.ResultsThere was a moderate correlation between before‐treatment hypercalcemia and after‐treatment hypocalcemia. The prospective study was terminated due to ethical concerns given findings in the retrospective section. All dogs were placed into groups according to their pretreatmentiCa: 1.46–1.61 mmol/L, 1.62–1.71 mmol/L,iCa 1.72–1.81 mmol/L, or >1.81 mmol/L. After treatment, the mean lowestiCa for each group, respectively, was 1.19, 1.18, 1.13, and 1.01 mmol/L. There was a significant association between higher group and proportion of dogs withiCa <1.00 mmol/L (P= .014).Conclusions and Clinical ImportanceThis study demonstrates a moderate correlation betweeniCa concentration before treatment and hypocalcemia after treatment. Dogs with higher initialiCa concentrations should be treated to prevent rapid decline and development of clinical hypocalcemia.
Management and prognosis of hepatocellular carcinoma in the elderly: Results of an in‐field multicenter cohort study
Authors: Borzio Mauro , Dionigi Elena , Vitale Alessandro , Rossini Angelo , Marignani Massimo , Fornari Fabio , Vicari Susanna , De Sio Ilario , Farinati Fabio , Bertolini Emanuela , Oliveri Filippo , Leandro Gioacchino , Francica Giampiero , Mitra Mario , Omazzi Barbara , Boccia Sergio , Salmi Andrea , Toldi Anna , Sacco Rodolfo 
Published: February 2017

AbstractAimsThis multicentre cohort study evaluated the role of ageing on clinical characteristics, treatment allocation and outcome of new hepatocellular carcinomas (HCCs), in clinical practice.Material & MethodsFrom September 2008, 541 patients >70 years old (elderly group), and 527 ≤70 years old (non‐elderly group) with newly diagnosed HCC were consecutively enrolled in 30 Italian centres. Differences in clinical characteristics and treatment allocation between groups were described by a multivariable logistic regression model measuring the inverse probability weight to meet the elderly group. Survival differences were measured by unadjusted and adjusted (by inverse probability weight) survival analysis.ResultsElderly patients were mainly females, hepatitis C virus infected and with better conserved liver function (P<.001). At presentation, HCC median size was similar in both groups while, in youngers, HCC was more frequently multinodular (P=.001), and associated with neoplastic thrombosis (P=.009). Adjusted survival analysis showed that age did not predict short–mid‐term survival (within 24 months), while it was a significant independent predictor of long‐term survival. Moreover, age had a significant long‐term survival impact mainly on early HCC stages (Barcelona Clinic for Liver Cancer [BCLC] 0‐A), its impact on BCLC B stage was lower, while it was negligible for advanced‐terminal stages.ConclusionsAge per se does not impact on short–mid‐term prognosis (≤24 months) of HCC patients, and should not represent a limitation to its management.