bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: DARST. CYCLISCHER UND ACYCLISCHER VINYLTRIFLUORMETHYLSULFONATE
Authors: DUEBER THOMAS E. , STANG PETER J. , PFEIFER WOLF D. , SUMMERVILLE RICHARD H. , IMHOFF MICHAEL A. , RAGUE SCHLEYER PAUL VON , HUMMEL KLAUS , BOCHER SIEGFRIED , HARDING CHARLES E. , HANACK MICHAEL 
Published: February 2016

AbstractAus den Cycloalkanonen (I) bzw. dem Isopropylmethylketon (IV) entstehen mit äquimolaren Mengen des Anhydrids (II) bei 15 bis 0° (2‐14 Tage) die Methansulfonate (III) (40‐50% Ausbeute) bzw. (V) (18%).
ChemInform Abstract: ANTI‐1,6.8,13‐BISMETHANO‐(14)ANNULEN
Authors: VOGEL EMANUEL , HABERLAND ULRICH , GUENTHER HARALD 
Published: February 2016

AbstractDurch Umsetzung des Dihydroannulens (I) mit 2 Mol N‐Brom‐succinimid und anschließende Reaktion des Dibromids (II) (vermutlich ein cis‐,trans‐Isomerengemisch) mit NaJ in Aceton unter N2 wird das Annulen (III) [58%Ausbeute bezogen auf (I)] erhalten, das unter N2 monatelang haltbar ist.
ChemInform Abstract: RINGSCHLUSSRK. IM ANSCHLUSS AN DIE ALLENUMLAGERUNG VON 1‐METHOXY‐1,1,5,5‐TETRAARYL‐PENTIN‐(2)‐ONEN‐(4) MIT ANORGANISCHEN SAEURECHLORIDEN
Authors: RIED WALTER , NEIDHARDT ROLF 
Published: February 2016

AbstractDie aus den entsprechenden Propinolen mit Dimethylsulfat erhältlichen Methoxypropine (I) werden mit Äthyl‐MgBr in die Grignardverbindungen übergeführt, die sofort mit Diphenylacetaldehyd zu den Pentinolen (II) weiterreagieren.
ChemInform Abstract: ANTIDEPRESSIVA UND NEUROLEPTISCHE TRICYCLEN 2. MITT. SYNTH. PARTIELL GESAETTIGTER ANALOGA VON AMITRIPTYLIN AUS O‐TOLUNITRILEN
Authors: DOSTERT P. , KYBURZ E. 
Published: February 2016

AbstractDie Nitrile (I) reagieren mit dem Bromid (II) zu den Nitrilen (III) (56‐70%Ausbeute), die beim Kochen mit KOH in Äthylenglykol Gemische aus denSäuren (IV) (70%) und den Amiden (V) liefern, wobei die Menge der Amidemit der Verseifungszeit variiert.
ChemInform Abstract: ZWEIFACHE FRAGMENTIERUNG VON THIACHROMANONEN‐(4) BEI DER BEHANDLUNG MIT SCHWEFEL‐YLIDEN, BLDG. VON THIANAPHTHENEN
Authors: SPECKAMP W. N. , DIJKINK J. , MAASSEN J. A. , HUISMAN H. O. 
Published: February 2016

AbstractDie Thiochromanone (II) liefern mit Dimethylsulfonium‐methylid (I) Gemische aus den Thianaphthenen (III) und den Cyclopropylketonen (IV), die sich durch alkalische Extraktion leicht trennen lassen.
ChemInform Abstract: IDENTITAET DER ABBAUPRODUKTE DES PHENYLBUTAZONS
Authors: SCHMID R. W. 
Published: February 2016

AbstractIn Ampullenpräparaten von Phenylbutazon (I) befinden sich infolge von Oxidations‐ und Hydrolyse‐Vorgängen dünnschichtchromatographisch nachweisbare Abbauprodukte, die als (II), (III) und (IV) identifiziert werden.
ChemInform Abstract: SYNTH. VON 10‐METHOXY‐1,2‐METHYLEN‐DIOXY‐7‐OXO‐DIBENZO(DE, G)CHINOLIN UND 9‐METHOXY‐1,2‐METHYLENDIOXY‐7‐OXO‐DIBENZO(DE, G)CHINOLIN (LANUGINOSIN)
Authors: GOVINDACHARI T. R. , VISWANATHAN N. , NARAYANASWAMI S. , PAI B. R. 
Published: February 2016

AbstractDurch Kondensation von Hydrastiniumjodid (I) mit den Toluolen (II) in Gegenwart von Na‐äthoxid erhält man die Tetrahydroisochinoline (III), die katalytisch zu den Aminen (IV) reduziert werden.
ChemInform Abstract: SYNTH. VON 2‐ UND 4‐AMINO‐1,5‐NAPHTHYRIDINEN
Authors: BROWN E. V. , PLASZ A. C. 
Published: February 2016

AbstractBei der Umsetzung von 1,5‐Naphthyridin (I) mit Kaliumamid in flüssigem Ammoniak wurde 4‐Amino‐1,5‐naphthyridin (II) erhalten.
ChemInform Abstract: THERMISCHE RK. VON TROPONAETHYLENKETAL
Authors: FUKUNAGA T. 
Published: February 2016

AbstractWird Troponäthylenketal (I) ohne Lösungsmittel oder mit Lösungsmitteln wie Acetonitril oder Cyclohexan im geschlossenen Rohr auf 110‐150° erhitzt, so entstehen in glatter Reaktion Benzol (II), Kohlendioxid (III), Äthylen (IV) und 3,4‐Dioxyäthylen‐cycloheptatrien (V).
ChemInform Abstract: ALKYLIERUNG VON ′MALONYL‐ALPHA‐AMINO‐PYRIDINEN′
Authors: URBAN RENE , GROSJEAN MIREILLE , ARNOLD WOLF 
Published: February 2016

AbstractDurch Kondensation von Aminopyridinen, wie z.B. (I), mit substituiertenMalonestern, wie z.B. (II), entstehen die Titelverbindungen (III) (68‐73%Ausbeute), die in Gegenwart von Na/Methanol mit den Halogeniden (IV) zueinem Gemisch aus den Betainen (V) (26‐56%), den Äthem (VI) (1 1‐‐28%)und den Amiden (VII) reagieren.
ChemInform Abstract: SYNTH. OXIDIERTER CAROTINOIDE
Authors: SURMATIS J. D. , WALSER A. , GIBAS J. , SCHWIETER U. , THOMMEN R. 
Published: February 2016

AbstractDie Ketone (I) werden nacheinander mit Phosphonoessigsäuretriäthylester, Li‐Al‐hydrid und Mn‐dioxid behandelt unter Bildung der Aldehyde (II), die nach Reaktion mit dem Phosphoniumbromid (III) und anschließender Hydrolyse ein Gemisch der Carotinoide (IV)‐(VI) in unterschiedlicher Zusammensetzung liefern.
ChemInform Abstract: SYNTH. VON HETEROCYCLISCHEN VERBINDUNGEN 349. MITT. TOTALSYNTH. VON (+‐)‐OBABERIN
Authors: KAMITANI T. , WAKISAKA K. , KIGASAWA K. 
Published: February 2016

AbstractDurch Bischler‐Napieralski‐Cyclisierung von (I) wurde ein Gemisch von (II) und (III) erhalten, das mit Natriumborhydrid in Methanol/Chloroform zu (IV) und (V) reduziert und anschließend mit Formaldehyd und Ameisensäure zu einem Gemisch von (VI) und (VII) methyliert wurde.
ChemInform Abstract: HEPATOTOXISCHE WIRKUNGEN VON PYRROLIZIDIN‐ALKALOIDEN UND ROLLE VON EPOXIDEN IN DER CARCINOGENESE
Authors: SCHOENTAL R. 
Published: February 2016

AbstractSenkirkin (I) und Hydroxysenkirkin (II), die zu den Pyrrolizidin‐Alkaloiden gehören, rufen bereits nach einmaliger Gabe bei Ratten Leberkrebs hervor.
ChemInform Abstract: SYNTH. DER 2‐THIO‐D‐GLUCOSE UND EINIGER 3‐THIO‐D‐ALTROSE‐DERIVATE
Authors: HARDEGGER E. , SCHUEEP W. 
Published: February 2016

AbstractDie aus Lävoglucosan in bekannter Weise erhältliche Dianhydromannose (I)wird durch Behandlung mit Na‐benzylmercaptid in die Glucose (IIa) (22% Ausbeute) und die Altrose (IIIa) (52%) übergeführt.
ChemInform Abstract: SYNTH. DES SELENANALOGONS DES NATUERLICH VORKOMMENDEN NUCLEOSIDS GUANOSIN, 6‐SELENOGUANOSIN
Authors: TOWNSEND L. B. , MILNE G. H. 
Published: February 2016

AbstractBei der Behandlung von (I) mit einer methanolischen Lösung von Natriumhydrogenselenid unter Rückfluß entsteht das Selenoguanosin (II) in einerAusbeute von 50%.
ChemInform Abstract: SYNTH. VON 5‐FORMYL‐2′‐DESOXYURIDIN UND DEM ALPHA‐ANOMEREN
Authors: MERTES M. P. , SHIPCHANDLER M. T. 
Published: February 2016

Abstract5‐Formyluracil (I) wurde silyliert und mit (II) in trockenem Aceton zu (III) kondensiert.
ChemInform Abstract: SYNTH. VON 9‐(3‐AMINO‐3‐DESOXY‐BETA‐D‐ARABINOFURANOSYL)‐ UND 9‐(2‐AMINO‐2‐DESOXY‐BETA‐D‐XYLOFURANOSYL)‐ADENIN
Authors: MARTINEZ A. P. , CALKINS D. F. , REIST E. J. , LEE W. W. , GOODMAN L. 
Published: February 2016

AbstractDie Verbindung (I) wurde in wäßrigem 2‐Methylglykol in Gegenwart von Ammoniumchlorid mit Natriumazid zu einem 15:1‐Gemisch der Azide (Ila)und (IIb) umgesetzt.
ChemInform Abstract: DITERPENOIDE 24. MITT. EINE PRUEFUNG DER AGATHIS‐SPECIES VON NORTH QUEENSLAND, ZWEI NEUE HARZSAEUREN
Authors: CARMAN R. M. , MARTY R. A. 
Published: February 2016

AbstractDie nichtpolymeren Säurefraktionen der Harze verschiedener Bäume werden methyliert und die erhaltenen Estergemische gaschromatographisch analysiert.
ChemInform Abstract: UNTERSUCHUNG DER NITRIERUNG VON 6‐METHOXY(HYDROXY)‐2‐PHENYL‐3‐HYDROXYPYRIDIN
Authors: SMIRNOV L. D. , AVEZOV M. R. , LEZINA V. P. , ALIEVA R. O. , DYUMAEV K. M. 
Published: February 2016

Abstract6‐Methoxy‐2‐phenyl‐3‐hydroxy‐pyridin (Ia) und 2‐Phenyl‐3,6‐dihydroxy‐pyridin (Ib) lassen sich in konz. Schwefelsäure bei 0°C mit 57%iger Salpetersäure im Benzolring zur 4‐Nitrophenyl‐Verbindung (II) nitrieren (Ausbeute 83‐85%).
ChemInform Abstract: NUCLEOSIDE 11. MITT. SYNTH. EINES BIOLOGISCH AKTIVEN GOUGEROTIN‐ANALOGONS
Authors: LICHTENTHALER FRIEDER W. , TRUMMLITZ GUENTER , BAMBACH GERD , RYCHLIK IVAN 
Published: February 2016

AbstractDas Glucopyranosid (I) geht bei Behandlung mit 40%igem HBr/Eisessig und anschließender Umsetzung mit 2,4‐Diäthoxy‐pyrimidin in das Nucleosidtetraacetat (II) über (36% Ausbeute).
ChemInform Abstract: CYCLISIERUNG UND FRAGMENTIERUNG VON N‐CHLOR‐LACTAMEN, TRANSANNULARE SYNTH. BICYCLISCHER LACTAME MIT BRUECKENKOPF‐STICKSTOFF
Authors: EDWARDS O. E. , PATON J. M. , BENN M. H. , MITCHELL R. E. , WATANATADA CHURAI , VOHRA K. N. 
Published: February 2016

AbstractDas N‐Chlor‐lactam (I) geht beim Erhitzen in Gegenwart von Benzoylperoxid in Dioxan‐Wasser auf 80‐85°C in ein Gemisch der Azabicyclononanone (II) (Ausbeute 32%) und (III) (63%) über.
Reversible client/server interactions
Authors: Barbanera Franco , Dezani-Ciancaglini Mariangiola , de’Liguoro Ugo 
Published: February 2016

Abstract

In the setting of
session behaviours
, we study an extension of the concept of compliance when a disciplined form of backtracking and of output skipping is present. After adding checkpoints to the syntax of session behaviours, we formalise the operational semantics via an LTS, and define natural notions of
checkpoint compliance
and
sub-behaviour
, which we prove to be both decidable. Then we extend the operational semantics with
skips
and we show the decidability of the obtained compliance.
Endothelial actions of atrial natriuretic peptide prevent pulmonary hypertension in mice
Authors: Werner Franziska , Kojonazarov Baktybek , Gaßner Birgit , Abeßer Marco , Schuh Kai , Völker Katharina , Baba Hideo A. , Dahal Bhola K. , Schermuly Ralph T. , Kuhn Michaela 
Published: February 2016

AbstractThe cardiac hormone atrial natriuretic peptide (ANP) regulates systemic and pulmonary arterial blood pressure by activation of its cyclic GMP-producing guanylyl cyclase-A (GC-A) receptor. In the lung, these hypotensive effects were mainly attributed to smooth muscle-mediated vasodilatation. It is unknown whether pulmonary endothelial cells participate in the homeostatic actions of ANP. Therefore, we analyzed GC-A/cGMP signalling in lung endothelial cells and the cause and functional impact of lung endothelial GC-A dysfunction. Western blot and cGMP determinations showed that cultured human and murine pulmonary endothelial cells exhibit prominent GC-A expression and activity which were markedly blunted by hypoxia, a condition known to trigger pulmonary hypertension (PH). To elucidate the consequences of impaired endothelial ANP signalling, we studied mice with genetic endothelial cell-restricted ablation of the GC-A receptor (EC GC-A KO). Notably, EC GC-A KO mice exhibit PH already under resting, normoxic conditions, with enhanced muscularization of small arteries and perivascular infiltration of inflammatory cells. These alterations were aggravated on exposure of mice to chronic hypoxia. Lung endothelial GC-A dysfunction was associated with enhanced expression of angiotensin converting enzyme (ACE) and increased pulmonary levels of Angiotensin II. Angiotensin II/AT1-blockade with losartan reversed pulmonary vascular remodelling and perivascular inflammation of EC GC-A KO mice, and prevented their increment by chronic hypoxia. This experimental study indicates that endothelial effects of ANP are critical to prevent pulmonary vascular remodelling and PH. Chronic endothelial ANP/GC-A dysfunction, e.g. provoked by hypoxia, is associated with activation of the ACE–angiotensin pathway in the lung and PH.
Altered mTOR signalling in nephropathic cystinosis
Authors: Ivanova Ekaterina A. , den van Heuvel Lambertus P. , Elmonem Mohamed A. , De Smedt Humbert , Missiaen Ludwig , Pastore Anna , Mekahli Djalila , Bultynck Greet , Levtchenko Elena N. 
Published: February 2016

AbstractLysosomes play a central role in regulating autophagy via activation of mammalian target of rapamycin complex 1 (mTORC1). We examined mTORC1 signalling in the lysosomal storage disease nephropathic cystinosis (MIM 219800), in which accumulation of autophagy markers has been previously demonstrated. Cystinosis is caused by mutations in the lysosomal cystine transporter cystinosin and initially affects kidney proximal tubules causing renal Fanconi syndrome, followed by a gradual development of end‐stage renal disease and extrarenal complications. Using proximal tubular kidney cells obtained from healthy donors and from cystinotic patients, we demonstrate that cystinosin deficiency is associated with a perturbed mTORC1 signalling, delayed reactivation of mTORC1 after starvation and abnormal lysosomal retention of mTOR during starvation. These effects could not be reversed by treatment with cystine‐depleting drug cysteamine. Altered mTORC1 signalling can contribute to the development of proximal tubular dysfunction in cystinosis and points to new possibilities in therapeutic intervention through modulation of mTORC‐dependent signalling cascades.
Species and clone‐dependent effects of tilapia fish (Cichlidae) on the morphology and life‐history of temperate and tropicalDaphnia
Authors: Tolardo Monique , da Silva Ferrão‐Filho Aloysio , Santangelo Jayme Magalhães 
Published: February 2016

AbstractIn aquatic systems, tilapia introductions may result in marked changes in the structure of prey communities. In this study, we experimentally examined the effects of tilapia‐mediated water at the individual and population levels of prey by exposing threeDaphniaspecies to predation cues. We hypothesized that tilapia‐mediated water determines reduced age and size at primipara, greater and faster reproduction, enhanced intrinsic rates of population increase (r), and longer tail spines inDaphnia; but that the magnitude of these changes would be species and clone‐dependent. When three tropicalD. laevisand one temperateD. similisclones were exposed to predation cues, adaptive changes were observed in some of the aforementioned parameters for each clone. The threeD. laevisclones exhibited changes in all life‐history and morphological measures. TemperateDaphnia spinulatadisplayed no changes but decreasedrvalues in the presence of predators. The observed changes in the species and clones tested here suggest that, overall, both temperate and tropicalDaphniacan detect and adaptively react to the risk of tilapia predation. However, only a fraction of the possible defenses may be displayed by individual clones. In contrast,D. spinulataseems more vulnerable to tilapia predation, given its long body length and absence of adaptive changes. Our study indicates thatDaphniacan respond to tilapia‐mediated water, and that interspecific and clonal variation exists between temperate and tropical species.
Considerations for the assessment of suicidal ideation and behavior in older adults with cognitive decline and dementia
Authors: Alphs Larry , Brashear H. Robert , Chappell Phillip , Conwell Yeates , Dubrava Sarah , Khin Ni A. , Kozauer Nicholas , Hartley Dean M. , Miller David S. , Schindler Rachel J. , Siemers Eric R. , Stewart Michelle , Yaffe Kristine 
Published: February 2016

AbstractIntroductionBetter understanding of suicide risk and its management in older adults with cognitive impairment and/or dementia remain significant unmet public health needs. Urgency to address them derives from concern that CNS treatments for dementia may impact suicide risk. Regulatory guidances requiring assessment of emergent suicidal ideation and behavior (SI/SB) at every clinical trial visit emphasize the need for understanding their prevalence.MethodsThe literature regarding SI/SB in older persons with cognitive impairment or dementia was reviewed by an Alzheimer's Association Taskforce with emphasis on epidemiology, classification, assessment, and regulatory requirements.ResultsGaps in our knowledge were identified, challenges discussed and recommendations for future work provided.DiscussionCurrently available SI/SB data from geriatric persons with dementia do not provide adequate understanding of its epidemiology, identification, assessment, or management. The growing public health burden of this population requires greater attention from clinicians and researchers on tactics and assessment tools to meet these needs.
Mandibular coronoid process fractures: Prevalence and characteristic multidetector CT findings
Authors: Ogura Ichiro , Hara Yoshinobu , Tokunaga Satoshi , Kaneda Takashi 
Published: February 2016

AbstractAim: The aim of this study was to investigate the prevalence and characteristic multidetector computed tomography (CT) (MDCT) findings of mandibular coronoid process fractures.Methods: A retrospective study was conducted on 376 patients with maxillofacial fractures who underwent 64‐MDCT. For patients with mandibular coronoid process fractures, age, gender, cause of injury, coronoid process fracture location, and other maxillofacial fracture location were analyzed.Results: Of all patients with maxillofacial fractures, 1.6% had mandibular coronoid process fractures. All patients with mandibular coronoid process fractures sustained other maxillofacial fractures as well. Furthermore, five (83.3%) of six patients with mandibular coronoid process fractures also had posterior maxillary sinus fractures.Conclusions: The results of the present study indicate the prevalence and characteristic MDCT findings of mandibular coronoid process fractures. Patients with mandibular coronoid process fractures may sustain other maxillofacial fractures, especially posterior maxillary sinus fractures.
Management of Bronchiolitis in Community Hospitals in Ontario: a Multicentre Cohort Study
Authors: Plint Amy C. , Taljaard Monica , McGahern Candice , Scott Shannon D. , Grimshaw Jeremy M. , Klassen Terry P. , Johnson David W. 
Published: February 2016

AbstractObjectivesBronchiolitis is the leading cause of hospital admission for infants, but few studies have examined management of this condition in community hospital settings. We reviewed the management of children with bronchiolitis presenting to community hospitals in Ontario.MethodsWe retrospectively reviewed a consecutive cohort of infants less than 12 months old with bronchiolitis who presented to 28 Ontario community hospitals over a two-year period. Bronchiolitis was defined as first episode of wheezing associated with signs of an upper respiratory tract infection during respiratory syncytial virus season.ResultsOf 543 eligible children, 161 (29.7%, 95% Confidence Interval (CI) 22.3 to 37.0%) were admitted to hospital. Hospital admission rates varied widely (Interquartile Range 0%-40.3%). Bronchodilator use was widespread in the emergency department (ED) (79.7% of patients, 95% CI 75.0 to 84.5%) and on the inpatient wards (94.4% of patients, 95% CI 90.2 to 98.6%). Salbutamol was the most commonly used bronchodilator. At ED discharge 44.7% (95% CI 37.5 to 51.9%) of patients were prescribed a bronchodilator medication. Approximately one-third of ED patients (30.8%, 95% CI 22.7 to 38.8%), 50.3% (95% CI 37.7 to 63.0%) of inpatients, and 23.5% (95% CI 14.4 to 32.7) of patients discharged from the ED were treated with corticosteroids. The most common investigation obtained was a chest x-ray (60.2% of all children; 95% CI 51.9 to 68.5%).ConclusionsInfants with bronchiolitis receive medications and investigations for which there is little evidence of benefit. This suggests a need for knowledge translation strategies directed to community hospitals.
Characteristics of Antimicrobial Stewardship Programs at Veterans Affairs Hospitals: Results of a Nationwide Survey
Authors: Chou Ann F. , Graber Christopher J. , Jones Makoto , Zhang Yue , Goetz Matthew Bidwell , Madaras-Kelly Karl , Samore Matthew , Kelly Allison , Glassman Peter A. 
Published: February 2016

BACKGROUNDAntimicrobial stewardship programs (ASPs) are variably implemented.OBJECTIVETo characterize variations of antimicrobial stewardship structure and practices across all inpatient Veterans Affairs facilities in 2012 and correlate key characteristics with antimicrobial usage.DESIGNA web-based survey regarding stewardship activities was administered to each facility’s designated contact. Bivariate associations between facility characteristics and inpatient antimicrobial use during 2012 were determined.SETTINGTotal of 130 Veterans Affairs facilities with inpatient services.RESULTSOf 130 responding facilities, 29 (22%) had a formal policy establishing an ASP, and 12 (9%) had an approved ASP business plan. Antimicrobial stewardship teams were present in 49 facilities (38%); 34 teams included a clinical pharmacist with formal infectious diseases (ID) training. Stewardship activities varied across facilities, including development of yearly antibiograms (122 [94%]), formulary restrictions (120 [92%]), stop orders for antimicrobial duration (98 [75%]), and written clinical pathways for specific conditions (96 [74%]). Decreased antimicrobial usage was associated with having at least 1 full-time ID physician (P=.03), an ID fellowship program (P=.003), and a clinical pharmacist with formal ID training (P=.006) as well as frequency of systematic patient-level reviews of antimicrobial use (P=.01) and having a policy to address antimicrobial use in the context of Clostridium difficile infection (P=.01). Stop orders for antimicrobial duration were associated with increased use (P=.03).CONCLUSIONSASP-related activities varied considerably. Decreased antibiotic use appeared related to ID presence and certain select practices. Further statistical assessments may help optimize antimicrobial practices.Infect Control Hosp Epidemiol 2016;37:647–654
Effect of wall suction on rotating disk absolute instability
Authors: Ho Joanna , Corke Thomas C. , Matlis Eric 
Published: February 2016

This research investigates the effect of uniform suction on the absolute instability of Type I cross-flow modes in the boundary layer on a rotating disk. Specifically, it is designed to investigate whether wall suction would transform the absolute instability into a global mode, as first postulated in the numerical simulations of Davies & Carpenter (J. Fluid Mech., vol. 486, 2003, pp. 287–329). The disk is designed so that with a suction parameter of $0.2$, the radial location of the absolute instability critical Reynolds number, $Re_{c_{A}}=650$, occurs on the disk. Wall suction is applied from $Re=317$ to 696.5. The design for wall suction follows that of Gregory & Walker (J. Fluid Mech., 1960, pp. 225–234) where an array of holes through the disk communicate between the measurement side of the disk and the underside of the disk which is inside of an enclosure that is maintained at a slight vacuum. The enclosure pressure is adjustable so that a range of suction or blowing parameters can be investigated. The holes in the measurement surface are covered by a compressed wire porous mesh to aid in uniformizing the suction on the measurement surface of the disk. The mesh is covered by a thin porous high-density polyethylene sheet featuring a $20~{\rm\mu}\text{m}$ pore size which provides a smooth finely porous surface. A companion numerical simulation is performed to investigate the effect that the size and vacuum pressure of the underside enclosure have on the uniformity of the measurement surface suction. Temporal disturbances are introduced using the method of Othman & Corke (J. Fluid Mech., 2006, pp. 63–94). The results document the evolution of disturbance wavepackets in space and time. These show a temporal growth of the wavepackets as the location of the absolute instability is approached which is in strong contrast to the temporal evolution without suction observed by Othman and Corke. The results appear to support the effect of wall suction on the absolute instability postulated by Thomas (PhD thesis, 2007, Cardiff University, UK) and Thomas & Davies (J. Fluid Mech., vol. 663, 2010, pp. 401–433).