bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated Modelling System with Uncertainty Analysis for Reservoir Water Quality Management in a Reclamation River Basin
Authors: Ham Jonghwa , Hong Yoon‐Seok Timothy 
Published: September 2016

AbstractA developed integrated modelling system with uncertainty analysis (Monte Carlo simulation and generalized likelihood uncertainty estimation) was used to evaluate the effect of uncertainty sources on long‐term water quality and develop river basin management measures to meet the specified water quality criteria based on the predicted probability of occurrence in the reclamation river basin. The results of the deterministic integrated modelling system without uncertainty analysis showed that the Hwaong Reservoir water quality for total phosphorus (T‐P) (0.094 mg l−1) in 2022 would meet the reservoir water quality standard (0.1 mg l−1). However, the water quality prediction for the Hwaong Reservoir in 2022 using the integrated modelling system with uncertainty analysis showed that only 28% would meet the T‐P water quality standard, indicating that to meet the water quality standard with a 90% level of confidence, further river basin management measures should be applied in addition to the construction of planned wastewater treatment plants and treatment wetlands. The developed integrated modelling system with uncertainty analysis was demonstrated to be advantageous because it can allow modellers to make useful decisions about whether a river basin management plan can meet specified water quality criteria based on the probability of occurrence. Copyright © 2016 John Wiley & Sons, Ltd.
Features selection, data mining and finacial risk classification: a comparative study
Authors: Lahmiri Salim 
Published: September 2016

SummaryThe aim of this paper is to compare several predictive models that combine features selection techniques with data mining classifiers in the context of credit risk assessment in terms of accuracy, sensitivity and specificity statistics. The t‐statistic, Battacharrayia statistic, the area between the receiver operating characteristic, Wilcoxon statistic, relative entropy, and genetic algorithms were used for the features selection task. The selected features are used to train the support vector machine (SVM) classifier, backpropagation neural network, radial basis function neural network, linear discriminant analysis and naive Bayes classifier. Results from three datasets using a 10‐fold cross‐validation technique showed that the SVM provides the best accuracy under all features selections techniques adopted in the study for all three datasets. Therefore, the SVM is an attractive classifier to be used in real applications for bankruptcy prediction in corporate finance and financial risk management in financial institutions. In addition, we found that our best results are superior to earlier studies on the same datasets.
Does the Harvesting Technique Affect the Properties of Adipose‐Derived Stem Cells?—The Comparative Biological Characterization
Authors: Bajek Anna , Gurtowska Natalia , Olkowska Joanna , Maj Małgorzata , Kaźmierski Łukasz , Bodnar Magdalena , Marszałek Andrzej , Dębski Robert , Drewa Tomasz 
Published: September 2016

ABSTRACTThe objective of this study was to evaluate complex biological properties of human stem cells isolated from adipose tissue (ASCs) harvested utilizing different methods: surgical resection (R), power‐assisted liposuction (PAL), and laser‐assisted liposuction (LAL). ASCs were isolated from healthy donors, due to surgical resection, power‐, and laser‐assisted liposuction. Isolated cells were characterized by their clonogenicity, proliferation rate, doubling time, multilineage differentiation, and senescence potential. The average number of ASCs from 1g/1 ml of solid adipose tissue/lipoaspirate was 2.9 × 105 ± 2.4 × 105, 1.1 × 105 ± 0.8 × 105, and 1.2 × 105 ± 0.7 × 105, respectively, for ASCsR, ASCsPAL, and ASCsLAL. However, number of colonies formed by ASCsR and ASCsPAL was significantly higher compared to the average number of colonies formed by ASCsLAL. Also, in comparison to other analyzed cell groups, ASCsPAL obtained the highest proliferative activity. All analyzed cells were characterized by stable expression of CD90 and CD44 markers during prolonged culture. Expression of CD34 and CD45 markers was decreasing in subsequent passages. Presented study shows that different ASCs collection method affects some basic characteristics of these cells, such as number of isolated cells, clonogeneity, or doubling time. J. Cell. Biochem. 118: 1097–1107, 2017. © 2016 Wiley Periodicals, Inc.
IL‐15 and RANKL Play a Synergistically Important Role in Osteoclastogenesis
Authors: Okabe Iichiro , Kikuchi Takeshi , Mogi Makio , Takeda Hiroaki , Aino Makoto , Kamiya Yosuke , Fujimura Takeki , Goto Hisashi , Okada Kosuke , Hasegawa Yoshiaki , Noguchi Toshihide , Mitani Akio 
Published: September 2016

ABSTRACTInterleukin‐15 (IL‐15), a cytokine secreted by several cell types, has important physiological roles in the activity, proliferation, and viability of immune cells. It has both chemoattractant and proinflammatory properties, and may promote bone destruction. A previous study has shown that IL‐15 alone exerts no effect on osteoclastogenesis. Therefore, the current study addressed the synergistic effect of IL‐15 on osteoclast formation using RAW264.7 (RAW) cells by co‐stimulation with receptor activator of nuclear factor (NF)‐κB ligand (RANKL) that has a major role in osteoclastogenesis involving the pathogenesis of rheumatoid arthritis and periodontal disease. Co‐stimulation of RAW cells by IL‐15 and RANKL significantly increased the gene expression of osteoclast differentiation and osteoclastogenesis markers compared with stimulation by RANKL or IL‐15 independently as evaluated by tartrate‐resistant acid phosphate‐positive cell numbers, the fusion index, a pit formation assay with Alizarin red staining (calcification estimation), and quantitative polymerase chain reaction. Phosphorylation of extracellular signal‐regulated kinase (ERK), c‐jun N‐terminal kinase, p38 mitogen‐activated protein kinase, and NF‐κB was significantly increased by RANKL and IL‐15 (P < 0.05) compared with RANKL alone. In addition, these differentiation activities induced by RANKL and IL‐15 were comparatively suppressed by inhibition of ERK, suggesting that this synergistic effect on osteoclastogenesis is mainly mediated by ERK. Taken together, our results demonstrate that IL‐15 and RANKL induce osteoclastogenesis synergistically, and IL‐15 might play a novel and major role in destructive inflammatory bone diseases. J. Cell. Biochem. 118: 739–747, 2017. © 2016 Wiley Periodicals, Inc.
mTORC1 Signaling Promotes Limb Bud Cell Growth and Chondrogenesis
Authors: Jiang Ming , Fu Xuejie , Yang Huilin , Long Fanxin , Chen Jianquan 
Published: September 2016

ABSTRACTmTORC1 signaling has been shown to promote limb skeletal growth through stimulation of protein synthesis in chondrocytes. However, potential roles of mTORC1 in prechondrogenic mesenchyme have not been explored. In this study, we first deleted Raptor, a unique and essential component of mTORC1, in prechondrogenic limb mesenchymal cells. Deletion of Raptor reduced the size of limb bud cells, resulting in overall diminution of the limb bud without affecting skeletal patterning. We then examined the potential role of mTORC1 in chondrogenic differentiation in vitro. Both pharmacological and genetic disruption of mTORC1 significantly suppressed the number and size of cartilage nodules in micromass cultures of limb bud mesenchymal cells. Similarly, inhibition of mTORC1 signaling in chondrogenic ATDC5 cells greatly impaired cartilage nodule formation, and decreased the expression of the master transcriptional factor Sox9, along with the cartilage matrix genes Acan and Col2a1. Thus, we have identified an important role for mTORC1 signaling in promoting limb mesenchymal cell growth and chondrogenesis during embryonic development. J. Cell. Biochem. 118: 748–753, 2017. © 2016 Wiley Periodicals, Inc.
Allergen‐Specific IgE Measurement: Intermethod Comparison of Two Assay Systems in Diagnosing Clinical Allergy
Authors: Bulat Lokas Sandra , Plavec Davor , Rikić Pišković Josipa , Živković Jelena , Nogalo Boro , Turkalj Mirjana 
Published: September 2016

BackgroundOur aim was to examine the performance of IMMULITE 2000 assay for specific IgE (sIgE) by comparing it with ImmunoCAP technology in light of a clinical background.MethodsMeasurements of sIgE were done in a selected patient group (N = 569; varied sample size for each allergen) and in a random sample group (N = 100; 8 allergens). sIgE results were correlated with skin‐prick test results (selected patients) and medical history (nonselected patients).ResultsWe have detected fair to excellent correlation and agreement between the results of both assays, despite their methodological differences, both in selected and nonselected patient group (ρc = 0.431–0.976; ρc = 0.390–0.972, respectively). Associations of sIgE levels with skin‐prick test (SPT) levels and medical history have shown significant correlation for both assays for majority of tested allergens, where applicable (D. pteronyssinus, cat dander, egg white, milk, peanut, orchard grass, Alternaria tenuis, and common ragweed in selected patients; birch, cat dander, common ragweed, D. pteronyssinus, and orchard grass in nonselected; P < 0.05 for all).ConclusionsLaboratory testing for sIgE can be successfully accomplished by IMMULITE 2000 immunoanalyzer at a diagnostic accuracy relative to SPT, comparable to the results acquired by CAP technology but not fully comparable on the level of an individual patient.
Experimental study for the establishment of an evaluation criterion for the image sticking effect in OLED TV panels
Authors: Jang Youn‐hee , Kim Ki‐tae , Lee Hye‐mi , Lee Jae‐eun , Kim Ji‐hoon , Oh Chang‐seok , Lee Duek‐jung , Jang Joong‐soon 
Published: September 2016

AbstractThe individual elements of organic light‐emitting diode (OLED) displays degrade at different rates, because each element emits light independently; the resulting luminance differences between individual elements cause image sticking—a phenomenon where a displayed text or pattern remains on the screen even after changing the image contents—and are therefore an important issue in OLED displays. However, the introduction of OLED technology into large TV displays is still recent, and no criterion for image sticking evaluation has yet been established. The keystone of a criterion for image sticking evaluation is the definition of the difference level between the luminance of individual elements at which the viewer feels that image sticking is present. Therefore, in this study, an image sticking perception experiment is carried out in accordance with statistically sound procedures for experimental design, using a comprehensive set of human subjects to evaluate the presence of image sticking in moving images. The obtained results are analyzed, and two criteria for image sticking evaluation are proposed.
Rate Coefficient for the Gas‐Phase OH + CHF=CF2 Reaction between 212 and 375 K
Authors: Baasandorj Munkhbayar , Burkholder James B. 
Published: September 2016

ABSTRACTRate coefficients, k(T), for the OH + CHF=CF2 (trifluoroethylene, HFO‐1123) gas‐phase reaction were measured under pseudo–first‐order conditions using pulsed laser photolysis to produce OH radicals and pulsed laser induced fluorescence to measure the OH radical temporal profile. Rate coefficients were measured over the temperature range 212–375 K at total pressures between 20 and 500 Torr (He, N2 bath gas). The rate coefficient was found to be independent of pressure over this range of pressure with a temperature dependence that is described by the Arrhenius expression (3.04 ± 0.30) × 10–12 exp[(312 ± 25)/T] cm3 molecule–1 s–1 with k(296 K) measured to be (8.77 ± 0.80) × 10–12 cm3 molecule–1 s–1 (quoted uncertainties are 2σ and include estimated systematic errors). Rate coefficients for the reaction of CHF=CF2 with 18OH and OD were also measured as part of this study at 296 and 373 K and a total pressure of ∼25 Torr (He). The isotope measurements were used to evaluate the observed OH radical regeneration. CHF=CF2 is a very short‐lived substance with an atmospheric lifetime of ∼1 day with respect to OH reactive loss, whereas the actual lifetime of CHF=CF2 will depend on the time and location of its emission. The global warming potential for CHF=CF2 on the 100‐year time horizon (GWP100) was estimated using the present results and a lifetime correction factor to be 3.9 × 10−3.
In vivo tumor identification of colorectal liver metastases with diffuse reflectance and fluorescence spectroscopy
Authors: Tanis Erik , Evers Danny J. , Spliethoff Jarich W. , Pully Vishnu V. , Kuhlmann Koert , van Coevorden Frits , Hendriks Benno H.W. , Sanders Joyce , Prevoo Warner , Ruers Theo J.M. 
Published: September 2016

Background and ObjectiveOver the last decade, an increasing effort has been put towards the implementation of optical guidance techniques to aid surgeons during cancer surgery. Diffuse reflectance spectroscopy (DRS) and fluorescence spectroscopy (FS) are two of these new techniques. The objective of this study is to investigate whether in vivo optical spectroscopy is able to accurately discriminate colorectal liver metastases (CRLM) from normal liver tissue in vivo.Materials and MethodsDRS and FS were incorporated at the tip of a needle and were used for in vivo tissue differentiation during resection of CRLM. Measurements were taken in and around the tumor lesions and measurement sites were marked and correlated to histology (i.e., normal liver tissue or tumor tissue). Patients with and without neoadjuvant systemic chemotherapy were included into the study.ResultsFour hundred and eighty‐four measurements were taken in and near 19 liver lesions prior to resection. Overall sensitivity and specificity for DRS was 95% and 92%, respectively. Bile was the most discriminative parameter. The addition of FS did not improve the overall accuracy. Sensitivity and specificity was not hampered by neo‐adjuvant chemotherapy; sensitivity and specificity after neo‐adjuvant chemotherapy were 92% and 100%, respectively.ConclusionWe have successfully integrated spectroscopy technology into a disposable 15 Gauge optical needle and we have shown that DRS and FS can accurately discriminate CRLM from normal liver tissue in the in vivo setting regardless of whether the patient was pre‐treated with systemic therapy. This technique makes in vivo guidance accessible for common surgical practice. Lasers Surg. Med. 48:820–827, 2016. © 2016 Wiley Periodicals, Inc.
Reinforcing Lessons for Business from the Marketing Revolution in U.S. Presidential Politics: A Strategic Triad
Authors: Newman Bruce I. 
Published: September 2016

ABSTRACTThe role of marketing in presidential politics in the United States has introduced lessons for marketing executives on how to more effectively build up brand loyalty and fend off competition. The same technological breakthroughs in marketing that have powered corporate America were used by the Obama presidential campaigns in both 2008 and 2012 to microtarget potential donors and voters, carry out massive fund‐raising campaigns, and energize a base of citizens through newly minted movements at a level of sophistication not witnessed previously in other sectors. The same techniques continued to be used in the 2016 presidential campaign, and the paradigm shift in marketing put forward in this article is represented with the introduction of a Strategic Triad that integrates the use of Big Data, microtargeting, and social media by organizations in the political, for‐profit, and nonprofit sectors.
Considering the Role of Affect and Anticipated Emotions in the Formation of Consumer Loyalty Intentions
Authors: Taylor Steven A. , Ishida Chiharu , Donovan Leigh Anne Novak 
Published: September 2016

ABSTRACTAjzen and Sheikh () recently challenge calls for adding explicit measures of emotions or affect as independent constructs into the Theory of Reasoned Action (TRA). This assertion has potentially significant theoretical and operational implications for marketers in terms of parsimony and insight. The specific questions of whether or not the addition of anticipated forms of emotions and/or hedonic attitudes to traditional attitude‐based models meaningfully contributes to understanding loyalty intention formation in a retail marketing setting are empirically assessed in this research. Results suggest that, consistent with the arguments of Perugini and Bagozzi (), the independent addition of anticipated emotions (AEs) to attitude models such as the TRA, Theory of Planned Behavior, and Model of Goal‐Directed Behavior (MGB) can be justified in terms of model fit with data, predictive validity (∆R2), and efficacy in explanation. Interestingly, however, and consistent with the theoretical arguments underlying the TRA, the models receiving the most overall support appear to be models wherein AttitudeOverall mediates the contributions of positive and negative AEs on endogenous variables such as Desires and IntentionsLoyalty. While it remains up to the individual marketer which perspective to embrace given the observed gains reported herein, the present research also supports the notion that the addition of hedonic attitude forms and/or AEs can offer an overall net gain for many marketers. The managerial and research implications of the results are discussed.
Effects of Product Option Framing and Temporal Distance on Consumer Choice: The Moderating Role of Process versus Outcome Mental Simulations
Authors: Lu Mingying , Jen William 
Published: September 2016

ABSTRACTThis research demonstrates that the type of product option framing (additive vs. subtractive) and the temporal distance between an option choice and later buying behavior can influence decision difficulty. In two studies, the authors show that consumers who engage in additive option framing experience greater difficulty in making decisions for the near future than for the distant future, whereas consumers who engage in subtractive option framing experience greater difficulty in making decisions for the distant future than for the near future. In addition, by using theories of mental simulation, the authors show that communication strategies that promote process simulations for distant‐future choices in the subtractive option framing condition and those that promote outcome simulations for near‐future choices in the additive option framing condition are most effective in reducing decision difficulty. These effects hold across varying product categories and varying option prices.
Male–Male Status Signaling through Favoring Organic Foods: Is the Signaler Perceived and Treated as a Friend or a Foe?
Authors: Puska Petteri , Kurki Sami , Lähdesmäki Merja , Siltaoja Marjo , Luomala Harri 
Published: September 2016

ABSTRACTEven though consumers’ status signaling is a heavily researched topic, empirical contributions from two important research areas—the mundane food context and prosocial status signaling between male consumers—to signaling literature are still scarce. Thus, this study empirically investigates how a male signaling about his status through favoring organic foods is perceived and treated by other males in two different sociocultural settings (urban vs. rural). In an urban area—but not in a rural—the pro‐organic signaler was perceived as more respected, altruistic, and affluent than a male who did not signal about this (he also received statistically more money in a charity donation task). This may indicate that signaling about this tendency—because it can be viewed as use of one's own resources for the benefit of others—is not only a way to attain status, but can also make others behave more positively toward the signaler.
Asymmetric Membranes from Two Chemically Distinct Triblock Terpolymers Blended during Standard Membrane Fabrication
Authors: Li Yuk Mun , Srinivasan Divya , Vaidya Parth , Gu Yibei , Wiesner Ulrich 
Published: September 2016

Deviating from the traditional formation of block copolymer derived isoporous membranes from one block copolymer chemistry, here asymmetric membranes with isoporous surface structure are derived from two chemically distinct block copolymers blended during standard membrane fabrication. As a first proof of principle, the fabrication of asymmetric membranes is reported, which are blended from two chemically distinct triblock terpolymers, poly(isoprene‐b‐styrene‐b‐(4‐vinyl)pyridine) (ISV) and poly(isoprene‐b‐styrene‐b‐(dimethylamino)ethyl methacrylate) (ISA), differing in the pH‐responsive hydrophilic segment. Using block copolymer self‐assembly and nonsolvent induced phase separation process, pure and blended membranes are prepared by varying weight ratios of ISV to ISA. Pure and blended membranes exhibit a thin, selective layer of pores above a macroporous substructure. Observed permeabilities at varying pH values of blended membranes depend on relative triblock terpolymer composition. These results open a new direction for membrane fabrication through the use of mixtures of chemically distinct block copolymers enabling the tailoring of membrane surface chemistries and functionalities.
image
Patients’ Perspectives on the Psychological Impact of Inflammatory Arthritis and Meeting the Associated Support Needs: Open‐Ended Responses in a Multi‐Centre Survey
Authors: Dures Emma , Fraser Isobel , Almeida Celia , Peterson Alice , Caesley Judy , Pollock Jon , Ambler Nicholas , Morris Marianne , Hewlett Sarah 
Published: September 2016

AbstractObjectivesPsychological support for inflammatory arthritis is recommended in rheumatology treatment guidelines. Previous research found that high numbers of patients would access such support but that provision is often inconsistent and inadequate. The present study explored patients’ perspectives on the nature of the psychological impact of inflammatory arthritis and how to meet the associated support needs.MethodsA cross‐sectional survey was conducted, using questionnaires which included three open‐ended questions about helpful and unhelpful psychological support. The questionnaires were administered to 1,080 patients at six regional rheumatology units across England, and 1,200 members of a national patient charity.ResultsA total of 1,210 (53%) patients completed the questionnaire, with 779 (64%) responding to the open‐ended questions: 80% female; mean age 59 years (12.6); disease duration <5 years (40%), 5–10 years (20%), >10 years (40%). Data were analysed using a hybrid content analysis. Four categories emerged: challenges of an altered life course (negative emotions, isolation and loneliness, a dysfunctional body, loss, strained relationships, and fears for the future); poor communication (feeling unheard, clinicians’ reluctance to address psychological issues, a lack of help to manage pain and fatigue, and struggling to ask for help); understood by others (sharing with people who have arthritis, supportive family and friends, whole team support, and understanding from clinicians); and acquiring strategies (ways of coping).ConclusionsPsychological distress was commonplace, and often attributed to fatigue and pain. In addition to peers and family, patients looked to the rheumatology team for validation and support. Further research will address the skills training needs of rheumatology teams to meet patients’ psychological support requirements.