bluuebunny/crossref_metadata_2025_split huggingface dataset:
A discovery‐driven approach to elucidate urinary metabolome changes after a regular and moderate consumption of beer and nonalcoholic beer in subjects at high cardiovascular risk
Authors: Quifer‐Rada Paola , Chiva‐Blanch Gemma , Jáuregui Olga , Estruch Ramon , Lamuela‐Raventós Rosa M. 
Published: June 2017

ScopeThe aim of this work was to study the urinary metabolomics changes of participants that consumed beer, nonalcoholic beer (na‐beer), and gin.Methods and resultsThirty‐three males at high cardiovascular risk between 55 and 75 years old participated in an open, randomized, crossover, controlled trial with three nutritional interventions consisting of beer, na‐beer, and gin for 4 wk. Diet and physical activity was monitored throughout the study and compliance was assessed by measurement of urinary isoxanthohumol.Metabolomic analysis was performed in urine samples by LC coupled to an LTQ‐Orbitrap mass spectrometer combined with univariate and multivariate statistical analysis. Ten metabolites were identified. Eight were exogenous metabolites related to beer, na‐beer, or gin consumption, but two of them were related to endogenic changes: hydroxyadipic acid linked to fatty acid oxidation, and 4‐guanidinobutanoic acid, which correlated with a decrease in urinary creatinine. Plasmatic acylcarnitines were quantified by targeted MS. A regular and moderate consumption of beer and na‐beer decreased stearoylcarnitine concentrations.ConclusionHumulinone and 2,3‐dihydroxy‐3‐methylvaleric acid showed to be potential biomarkers of beer and na‐beer consumption. Moreover, the results of this trial provide new evidence that the nonalcoholic fraction of beer may increase fatty oxidation.
Resveratrol suppresses lipoprotein‐associated phospholipase A2 expression by reducing oxidative stress in macrophages and animal models
Authors: Sun Shengnan , Zhang Mingjun , Yang Qiangbing , Shen Ziying , Chen Jiahuan , Yu Biao , Wang He , Qu Jiali , Pang Daxin , Ren Wenzhi , Ouyang Hongsheng , Tang Xiaochun 
Published: June 2017

ScopeResveratrol is a naturally occurring polyphenolic compound with known cardioprotective, anti‐inflammatory, and antioxidant properties. Lipoprotein‐associated phospholipase A2 (Lp‐PLA2) is associated with the risk of cardiovascular disease. Here, we investigated the effects of resveratrol on Lp‐PLA2 expression in vitro and in vivo and explored the underlying mechanisms.Methods and resultsHuman monocytic cells (THP‐1) were induced to differentiate into macrophages for an in vitro experimental model. Resveratrol suppressed Lp‐PLA2 expression and reduced inflammation; lipopolysaccharide (LPS, 1 μg/mL), tumor necrosis factor‐α (TNF‐α, 10 ng/mL) and reactive oxygen species (ROS) were employed to stimulate an increase in Lp‐PLA2 expression and ROS levels, and the stimulation was inhibited by resveratrol (50 μM) and other antioxidants. The inhibition of resveratrol was inversed partially by sirtuin 1 (SIRT1) inhibitors (Nicotinamide, 1–10 mM) (p<0.05). Next, a chronic inflammation mouse model induced by a HFD (high fat diet) supplemented with resveratrol 100 mg/kg/day orally for 12 weeks, resulted in resveratrol‐induced decreases in the Lp‐PLA2 levels in the plasma and liver and increases in the superoxide dismutase 2 (SOD2) expression in the liver (p<0.05).ConclusionBased on our results, the protective effects of resveratrol on cardiovascular events may be related to its ability to suppress Lp‐PLA2 expression.
Relationship between lower urinary tract symptoms and cardiovascular risk scores including Framingham risk score and ACC/AHA risk score
Authors: Lee Bora , Lee Sang Wook , Kang Hye Rim , Kim Dae In , Sun Hwa Yeon , Kim Jae Heon 
Published: June 2017

AimsThis study attempted to investigate the association between lower urinary tract symptoms (LUTS) and cardiovascular disease (CVD) risk using International Prostate Symptom Score (IPSS) and CVD risk scores and to overcome the limitations of previous relevant studies.MethodsA total of 2994 ostensibly healthy males, who participated in a voluntary health check in a health promotion center from January 2010 to December 2014, were reviewed. CVD risk scores were calculated using Framingham risk score and American College of Cardiology (ACC)/American Heart Association (AHA) score. Correlation and multivariate logistic regression analysis to predict the CVD risk severity were performed.ResultsCorrelation between total IPSS with CVD risk scores demonstrated significant positive associations, which showed higher correlation with ACC/AHA score than the Framingham score (r = 0.18 vs 0.09, respectively). For ACC/AHA score, the partial correlation after adjustment of body mass index (BMI) showed significant positive correlations between all LUTS parameters and PSA. For the Framingham score, all variables, except IPSS Q2 and IPSS Q6, showed significant positive correlations. After adjustment of BMI, prostate volume and PSA, only the severe LUTS group showed significant relationship with intermediate‐high CVD risk severity, as compared with normal LUTS group (OR = 2.97, 95%CI (1.35‐6.99)).ConclusionUsing two validated CVD risk calculators, we observed that LUTS is closely associated with future CVD risk. To predict the intermediate‐high CVD risk severity, severe LUTS was a sentinel sign, the presence of which warrants the importance of an earlier screening for CVD.
Padé approximants and the modal connection: Towards increased robustness for fast parametric sweeps
Authors: Rumpler Romain 
Published: June 2017

SummaryTo increase the robustness of a Padé‐based approximation of parametric solutions to finite element problems, an a priori estimate of the poles is proposed. The resulting original approach is shown to allow for a straightforward, efficient, subsequent Padé‐based expansion of the solution vector components, overcoming some of the current convergence and robustness limitations. In particular, this enables for the intervals of approximation to be chosen a priori in direct connection with a given choice of Padé approximants. The choice of these approximants, as shown in the present work, is theoretically supported by the Montessus de Ballore theorem, concerning the convergence of a series of approximants with fixed denominator degrees. Key features and originality of the proposed approach are (1) a component‐wise expansion which allows to specifically target subsets of the solution field and (2) the a priori, simultaneous choice of the Padé approximants and their associated interval of convergence for an effective and more robust approximation. An academic acoustic case study, a structural‐acoustic application, and a larger acoustic problem are presented to demonstrate the potential of the approach proposed.
Self‐Assembly of G‐Rich Oligonucleotides Incorporating a 3′–3′ Inversion of Polarity Site: A New Route Towards G‐Wire DNA Nanostructures
Authors: Oliviero Giorgia , D'Errico Stefano , Pinto Brunella , Nici Fabrizia , Dardano Principia , Rea Ilaria , De Stefano Luca , Mayol Luciano , Piccialli Gennaro , Borbone Nicola 
Published: June 2017

AbstractObtaining DNA nanostructures with potential applications in drug discovery, diagnostics, and electronics in a simple and affordable way represents one of the hottest topics in nanotechnological and medical sciences. Herein, we report a novel strategy to obtain structurally homogeneous DNA G‐wire nanostructures of known length, starting from the short unmodified G‐rich oligonucleotide d(5′‐CGGT‐3′–3′‐GGC‐5′) (1) incorporating a 3’–3′ inversion of polarity site. The reported approach allowed us to obtain long G‐wire assemblies through 5′–5′ π–π stacking interactions in between the tetramolecular G‐quadruplex building blocks that form when 1 is annealed in the presence of potassium ions. Our results expand the repertoire of synthetic methodologies to obtain new tailored DNA G‐wire nanostructures.
Agreement and validity of electronic health record prescribing data relative to pharmacy claims data: A validation study from a US electronic health record database
Authors: Rowan Christopher G. , Flory James , Gerhard Tobias , Cuddeback John K. , Stempniewicz Nikita , Lewis James D. , Hennessy Sean 
Published: June 2017

AbstractBackgroundGranular clinical and laboratory data available in electronic health record (EHR) databases provide researchers the opportunity to conduct investigations that would not be possible in insurance claims databases; however, for pharmacoepidemiology studies, accurate classification of medication exposure is critical.ObjectiveThe aim of this study was to evaluate the validity of classifying medication exposure using EHR prescribing (EHR‐Rx) data.MethodsWe conducted a retrospective cohort study among patients with linked claims and EHR data in OptumLabs™ Data Warehouse. The agreement between EHR‐Rx data and pharmacy claims (PC‐Rx) data (for 40 medications) was determined using the positive predictive value (PPV) and medication possession ratio (MPR)—calculated in 1‐ and 12‐month medication exposure periods (MEPs). Secondary analyses were restricted to incident vs prevalent EHR‐Rxs, age ≥65 vs <65, white vs black race, males vs females, and number of EHR‐Rxs.ResultsThe validity metrics varied substantially among the 40 medications assessed. Across all medications, the period PPV and MPR were 62% and 63% in the 1‐month MEP. They were 78% and 43% in the 12‐month MEP. Overall, PPV and MPR were higher for patients with a prevalent EHR‐Rx and age <65.ConclusionsDespite substantial variability among different medications, there was very good agreement between EHR‐Rx data and PC‐Rx data. To maximize the validity of classifying medication exposure with EHR prescribing data, researchers may consider using longer MEPs (eg, 12 months) and potentially require multiple EHR‐Rxs to classify baseline medication exposure.
Simple method for determining of the isokinetic temperature value for the SNAr reactions in solution
Authors: Vlasov Vladislav M. 
Published: June 2017

AbstractThe changes of the free energy of activation δ∆G≠exp and the activation entropy δ∆S≠ in the framework of the isokinetic relationship δ∆G≠exp versus (Tiso − Texp) δ∆S≠ were explored quantitatively to predict the isokinetic temperature Tiso for the aromatic nucleophilic substitution reactions in solution.
Crystal structure of human WBSCR16, an RCC1‐like protein in mitochondria
Authors: Koyama Masako , Sasaki Taeko , Sasaki Narie , Matsuura Yoshiyuki 
Published: June 2017

AbstractWBSCR16 (Williams‐Beuren Syndrome Chromosomal Region 16) gene is located in a large deletion region of Williams‐Beuren syndrome (WBS), which is a neurodevelopmental disorder. Although the relationship between WBSCR16 and WBS remains unclear, it has been reported that WBSCR16 is a member of a functional module that regulates mitochondrial 16S rRNA abundance and intra‐mitochondrial translation. WBSCR16 has RCC1 (Regulator of Chromosome Condensation 1)‐like amino acid sequence repeats but the function of WBSCR16 appears to be different from that of other RCC1 superfamily members. Here, we demonstrate that WBSCR16 localizes to mitochondria in HeLa cells, and report the crystal structure of WBSCR16 determined to 2.0 Å resolution using multi‐wavelength anomalous diffraction. WBSCR16 adopts the seven‐bladed β‐propeller fold characteristic of RCC1‐like proteins. A comparison of the WBSCR16 structure with that of RCC1 and other RCC1‐like proteins reveals that, although many of the residues buried in the core of the β‐propeller are highly conserved, the surface residues are poorly conserved and conformationally divergent.
Schottky barrier diodes based on room temperature fabricated amorphous zinc tin oxide thin films
Authors: Schlupp Peter , von Wenckstern Holger , Grundmann Marius 
Published: June 2017

AbstractWe report on Schottky barrier diodes on the amorphous oxide semiconductor zinc tin oxide (ZTO). The ZTO thin films were grown by pulsed laser deposition at room temperature. Reactively sputtered gold, nickel, platinum, palladium, and silver layers were used to realize the Schottky contacts. To enhance rectification, a thin semi‐insulating zinc tin oxide layer was introduced at the metal–semiconductor interface. The forward current–voltage characteristics of the platinum Schottky barrier diodes were modeled using thermionic emission theory. From temperature dependent measurements, the mean barrier heights of the diodes were determined to be 0.8 and 1.3 eV for diodes without and with a semi‐insulating layer, respectively. Further, the Pt–ZTO diodes were investigated by capacitance–voltage measurements and thermal admittance spectroscopy (TAS). We found that the obtained net doping density agrees with the free electron density determined from Hall‐effect measurements. TAS revealed two defect levels: one deep defect with an activation energy of 220 meV and one shallow defect connected to the carrier freeze‐out. Assuming scattering at potential barriers within the conduction band minimum being the dominant scattering mechanism in multi‐cation semiconductors at freeze‐out temperature, an activation energy of about 15–27 meV was derived.
Re‐evaluation of the VSI‐ chart performance with estimated parameters
Authors: Noorossana Rassoul , Mohammadpanah Mohammad , Nayebpour Mohamad R. 
Published: June 2017

AbstractThe performance of the variable sampling interval‐
(VSI‐
) chart with estimated parameters has been investigated on the basis of the average time to signal (ATS) and standard deviation of time to signal (SDTS) in past research studies. Since the values of ATS and SDTS vary from practitioner to practitioner, the use of these 2 measures is not reliable. The use of different historical data sets in phase I results in varying parameter estimates, control limits, warning limits, ATS, and SDTS values. In this study, we use the standard deviation of average time to signal (SDATS) to evaluate and compare the performance of the VSI‐
chart with known parameters and estimated parameters. This study shows that variation reduction in ATS values requires a larger than previously recommended phase I data. Also, detection of up to moderate shifts in the process mean with the desired ATS value would be achievable with the number of samples recommended in the past, but the in‐control performance of the chart would not be reliable. Furthermore, we evaluate the effect of using large and small desired values of ATS0 on the performance of in‐control and out‐of‐control VSI‐
chart. We also study the effects of estimating the mean and standard deviation on the ATS values using numerical simulation. Finally, we present a method based on warning and control limits coefficients for the estimated parameters case to reduce the number of samples required in phase I.
Using independent component analysis to monitor2‐Dgeometric specifications
Authors: Fathizadan Sepehr , Niaki Seyed Taghi Akhavan , Noorossana Rassoul 
Published: June 2017

AbstractFunctional data and profiles are characterized by complex relationships between a response and several predictor variables. Fortunately, statistical process control methods provide a solid ground for monitoring the stability of these relationships over time. This study focuses on the monitoring of 2‐dimensional geometric specifications. Although the existing approaches deploy regression models with spatial autoregressive error terms combined with control charts to monitor the parameters, they are designed based on some idealistic assumptions that can be easily violated in practice. In this paper, the independent component analysis (ICA) is used in combination with a statistical process control method as an alternative scheme for phase II monitoring of geometric profiles when non‐normality of the error term is present. The performance of this method is evaluated and compared with a regression‐ and PCA‐based approach through simulation of the average run length criterion. The results reveal that the proposed ICA‐based approach is robust against non‐normality in the in‐control analysis, and its out‐of‐control performance is on par with that of the PCA‐based method in case of normal and near‐normal error terms.
Estimating missing values from negligible interactions in factorial designs
Authors: Xampeny Rafel , Grima Pere , Tort‐Martorell Xavier 
Published: June 2017

AbstractWhen a factorial design has some missing value but there are contrasts (at least as many as there are missing values) corresponding to interactions that can be considered negligible, equating the expressions of those contrasts to 0 allows the missing values to be deduced. This procedure allows estimating values that correspond to runs that have gone wrong or could not be performed as planned, as well as to reduce the experimental plan while saving some runs whose results can be estimated a posteriori. The problem is that the estimated values have a variance that is higher than that of the experimental runs, and the variance depends on which are the missing values and the contrasts used to make the estimate. This article performs a thorough analysis of the variances obtained by estimating up to 2 missing values in 8‐run designs and up to 5 in 16‐run designs, with tables included which provide the missing values and contrasts that should be used to obtain estimates that have minimal variability.
Impact of metabolic disorders on prostate cancer growth: Androgen and insulin resistance perspectives
Authors: Yanase Tashihiko , Kawanami Takako , Tanaka Tomoko , Tanabe Makito , Nomiyama Takashi 
Published: June 2017

AbstractBackgroundA high prevalence of cancers in metabolic disorders, like metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM), recently has been noted, including prostate cancer (PC), which is androgen‐sensitive. However, the pathological relationship among testosterone and insulin and insulin‐like growth factor (IGF)‐1 signaling in relation to MetS and T2DM with PC remains unclear.MethodsPapers were reviewed, including those by the authors.ResultsIn MetS or the initial stage of T2DM accompanying insulin resistance, insulin and IGF‐1 signaling could be essential for PC growth. In the advanced stage of T2DM, the decrease in insulin secretion might work against PC growth. A decrease in testosterone concentration with T2DM also might suppress PC proliferation. Androgen deprivation therapy in patients with PC might increase the risk of MetS and/or T2DM and consequently cardiovascular events. Certain drugs for T2DM treatment, such as metformin and glucagon‐like peptide‐1 analog, potentially might be useful for the treatment of PC.ConclusionThe improvement of insulin resistance appears to be essential for the prevention of PC growth. Further studies are needed to clarify the complicated pathophysiology of metabolic disorders in PC growth.
Precisely Tailored DNA Nanostructures and their Theranostic Applications
Authors: Zhu Bing , Wang Lihua , Li Jiang , Fan Chunhai 
Published: June 2017

AbstractA critical challenge in nanotechnology is the limited precision and controllability of the structural parameters, which brings about concerns in uniformity, reproducibility and performance. Self‐assembled DNA nanostructures, as a newly emerged type of nano‐biomaterials, possess low‐nanometer precision, excellent programmability and addressability. They can precisely arrange various molecules and materials to form spatially ordered complex, resulting in unambiguous physical or chemical properties. Because of these, DNA nanostructures have shown great promise in numerous biomedical theranostic applications. In this account, we briefly review the history and advances on construction of DNA nanoarchitectures and superstructures with accurate structural parameters. We focus on recent progress in exploiting these DNA nanostructures as platforms for quantitative biosensing, intracellular diagnosis, imaging, and smart drug delivery. We also discuss key challenges in practical applications.
Single Versus Multiple Solid Organ Injuries Following Blunt Abdominal Trauma
Authors: El‐Menyar Ayman , Abdelrahman Husham , Al‐Hassani Ammar , Peralta Ruben , AbdelAziz Hiba , Latifi Rifat , Al‐Thani Hassan 
Published: June 2017

AbstractBackgroundWe aimed to describe the pattern of solid organ injuries (SOIs) and analyze the characteristics, management and outcomes based on the multiplicity of SOIs.MethodsA retrospective study in a Level 1 trauma center was conducted and included patients admitted with blunt abdominal trauma between 2011 and 2014. Data were analyzed and compared for patients with single versus multiple SOIs.ResultsA total of 504 patients with SOIs were identified with a mean age of 28 ± 13 years. The most frequently injured organ was liver (45%) followed by spleen (30%) and kidney (18%). One‐fifth of patients had multiple SOIs, of that 87% had two injured organs. Patients with multiple SOIs had higher frequency of head injury and injury severity scores (p < 0.05). The majority of SOIs were treated nonoperatively, whereas operative management was required in a quarter of patients, mostly in patients with multiple SOIs (p = 0.01). Blood transfusion, sepsis and hospital stay were greater in multiple than single SOIs (p < 0.05). The overall mortality was 11% which was comparable between the two groups. In patients with single SOIs, the mortality was significantly higher in those who had pancreatic (28.6%) or hepatic injuries (13%) than the other SOIs.ConclusionSOIs represent one‐tenth of trauma admissions in Qatar. Although liver was the most frequently injured organ, the rate of mortality was higher in pancreatic injury. Patients with multiple SOIs had higher morbidity which required frequent operative management. Further prospective studies are needed to develop management algorithm based on the multiplicity of SOIs.