bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of Vocal Health in Young Adults Attending College in the United States
Authors: Hartley Naomi A. , Breen Ellen , Thibeault Susan L. 
Published: October 2016

Purpose
The purpose of this study was to document typical vocal health characteristics (including voice-related activities, behaviors, and symptomatology) of young adults attending college and to determine lifetime and point prevalence rates of voice disorders.

Method
Undergraduates at University of Wisconsin–Madison completed an anonymous online survey detailing vocal use, symptomatology, impact, sociodemographics, and voice-related quality of life. Univariate analyses and multivariate regression models isolated risk factors for lifetime and point prevalence rates of a voice disorder.

Results

Vocal health and associated factors were analyzed for 652 students (predominantly 18–25 years of age). Lifetime prevalence rate of a voice disorder was 33.9% (point prevalence = 4.45%). Change in voice function (odds ratio [OR] = 2.77), seasonal or chronic postnasal drip (OR = 2.11), hoarseness (OR = 2.08), and restrictions to social activity (OR = 2.07; all
p
< .05) were identified as the strongest predictors of disorder. A total of 46% of students reported some form of voice problem in the past year, most frequently lasting between 1 and 6 days (39%). Voice usage in social and work settings exceeded demands in the classroom.

Conclusions
Young adults in college frequently experience disturbances to vocal health; however, this is not usually perceived to interfere with communication. Relative weighting of risk factors appears to differ from older adults, highlighting the need for individualized evaluation and management, with reference to age-appropriate normative reference points.
Design of compact size and tunable band pass filter for WLAN applications
Authors: Boutejdar A. , Ibrahim A.A. , Ali W.A.E. 
Published: October 2016

Compact size and tunable band pass filter based on open‐loop resonators is proposed. The proposed structure consists of dual‐armed microstrip open‐loop resonators. A second armed open‐loop resonator, which acts as band rejection resonator, is connected directly to the input and output ports to achieve the desired band pass behaviour. The open‐loop microstrip resonators are combined with four lumped capacitors to reduce the overall size of the proposed filter. The capacitors are inserted at places where maximum electric field is occurred in order to increase the effective capacitance and reduce the resonant frequency as well. The resonance frequency is translated from 6.75 to 5.3 GHz for WLAN applications. Consequently, the filter size will be more compact and the filter performance will be improved by enhancing the energy stored in the resonator. The proposed design using lumped capacitors represents a reduction in size of more than 35% when compared with conventional filter without using lumped capacitors. A good consistency is achieved between simulated and measured results.
Experimental investigation of multi‐path and metal‐stacking structure for 8‐shape on‐chip inductors on standard CMOS
Authors: Zou Wanghui , Chen Diping , Peng Wei , Zeng Yun 
Published: October 2016

An experimental investigation reports on the effectiveness of multi‐path and metal‐stacking structure in regard to quality factor improvement for on‐chip 8‐shaped inductors on standard CMOS process. It is found that the multi‐path structure has little positive impact on the 8‐shaped inductors, while the metal‐stacking structure improves quality factor significantly. For a 0.5 nH 8‐shaped inductor with top two layers metal‐stacking, a good differential quality factor of ∼15 at 10 GHz and ∼17 at 13 GHz is obtained, which makes the inductor suitable for the design of low‐cost and interference‐immune over‐10 GHz radio‐frequency and high‐speed integrated circuits.
Optimisation analysis of solar powered organic Rankine cycle system
Authors: Bataineh Khaled M. 
Published: October 2016

This study investigates the performance of solar powered organic Rankine cycle (ORC) system. Parabolic trough collector PTC is utilised in this study. The selected site is located in the northern part of Jordan. Simulation models are built to assess the performance of system. The simulation models are built by means of mass and energy balances applied to every component of the system. The model simulates the hourly thermal behaviour of all system components. Different working fluids are compared. The effect of key operating variables on the system performance is examined. Simulation results show that there is an optimum values for mass flow rate, and inlet turbine pressure for each months. For the working fluid studied, the average daily overall efficiency ranges between 9 to 22% during summer time. The comparison between working fluids showed that the most efficient fluid is Butane. The optimal daily average overall efficiency reaches 18%. It is found that using PTC of area of 617 m2 with ORC is reliable system producing above 80 kW during summer time. Mass flow rates have major effect on the cost of energy production. Furthermore, this study presents design optimisation so that solar thermal power plant can achieve higher reliable continuous operation with system components.
Going up, going down: the experience, control and management of gestational diabetes mellitus among Southeast Asian migrant women living in urban Australia
Authors: Jirojwong Sansnee , Brownhill Suzanne , Dahlen Hannah G. , Johnson Maree , Schmied Virginia 
Published: October 2016

Issue addressedIn many developed countries the rate of gestational diabetes mellitus (GDM) for Asian‐born women is higher than other groups. Studies suggest that some women have limited knowledge of the disease and poor self‐management leading to health problems for themselves and their baby. Few studies report the experience of GDM among Southeast Asian migrant women living in Australia and factors that influence their management of the disease.MethodsA qualitative interpretive design was used to explore Southeast Asian migrant women’s experience and management of GDM. Women diagnosed with the disease during pregnancy were recruited from an antenatal clinic at two Sydney metropolitan hospitals. Nineteen women were interviewed in their first language. Thematic analysis was used to analyse the data.ResultsA diagnosis of GDM conferred an unanticipated ‘up and down’ experience for this group of Southeast Asian women. Their experience of the disease, likened to an elevator ride, was modulated by ‘insulin’ and ‘information’ used to control the disease and manage blood glucose levels, dietary levels, exercise levels and anxiety levels.ConclusionsHealth promotion material that captures the fluctuating experience of GDM has the potential to help women, particularly at the time of diagnosis, to be better prepared, and health professionals to be better informed to control and manage the disease more effectively.So what?GDM is a serious problem. The model generated from our study has the potential to better inform health professionals to prepare women for the inevitable fluctuating physical and emotional effects of the disease. Culturally sensitive material and an educational strategy based on the model may also facilitate women’s lifestyle changes and compliance, and improve migrant women’s relationship with, and trust in, health professionals involved in their GDM care.
Pulmonary vascular effect of insulin in a rodent model of pulmonary arterial hypertension
Authors: Trammell Aaron W. , Talati Megha , Blackwell Thomas R. , Fortune Niki L. , Niswender Kevin D. , Fessel Joshua P. , Newman John H. , West James D. , Hemnes Anna R. 
Published: October 2016

Pulmonary arterial hypertension (PAH) is associated with metabolic derangements including insulin resistance, although their effects on the cardiopulmonary disease are unclear. We hypothesized that insulin resistance promotes pulmonary hypertension (PH) development and mutations in type 2 bone morphogenetic protein receptor (BMPR2) cause cellular insulin resistance. Using a BMPR2 transgenic murine model of PAH and two models of inducible diabetes mellitus, we explored the impact of hyperglycemia and/or hyperinsulinemia on development and severity of PH. We assessed insulin signaling and insulin‐mediated glucose uptake in human endothelial cells with and without mutations in BMPR2. PH developed in control mice fed a Western diet and PH in BMPR2 mutant mice was increased by Western diet. Pulmonary artery pressure correlated strongly with fasting plasma insulin but not glucose. Reactive oxygen species were increased in lungs of insulin‐resistant animals. BMPR2 mutation impaired insulin‐mediated endothelial glucose uptake via reduced glucose transporter translocation despite intact insulin signaling. Experimental hyperinsulinemia is strongly associated with PH in both control and BMPR2‐mutant mice, though to a greater degree in those with BMPR2 mutation. Human pulmonary endothelial cells with BMPR2 mutation have evidence of reduced glucose uptake due to impaired glucose transporter translocation. These experiments support a role for hyperinsulinemia in pulmonary vascular disease.
ViSiBooL—visualization and simulation of Boolean networks with temporal constraints
Authors: Schwab Julian , Burkovski Andre , Siegle Lea , Müssel Christoph , Kestler Hans A 
Published: October 2016

Abstract

Summary
Mathematical models and their simulation are increasingly used to gain insights into cellular pathways and regulatory networks. Dynamics of regulatory factors can be modeled using Boolean networks (BNs), among others. Text-based representations of models are precise descriptions, but hard to understand and interpret. ViSiBooL aims at providing a graphical way of modeling and simulating networks. By providing visualizations of static and dynamic network properties simultaneously, it is possible to directly observe the effects of changes in the network structure on the behavior. In order to address the challenges of clear design and a user-friendly graphical user interface (GUI), ViSiBooL implements visual representations of BNs. Additionally temporal extensions of the BNs for the modeling of regulatory time delays are incorporated. The GUI of ViSiBooL allows to model, organize, simulate and visualize BNs as well as corresponding simulation results such as attractors. Attractor searches are performed in parallel to the modeling process. Hence, changes in the network behavior are visualized at the same time.

Availability and Implementation
ViSiBooL (Java 8) is freely available at http://sysbio.uni-ulm.de/?Software:ViSiBooL.
A sensitized mutagenesis screen in Factor V Leiden mice identifies novel thrombosis suppressor loci
Authors: Westrick Randal J. , Tomberg Kärt , Siebert Amy E. , Zhu Guojing , Winn Mary E. , Dobies Sarah L. , Manning Sara L. , Brake Marisa A. , Cleuren Audrey C. , Hobbs Linzi M. , Mishack Lena M. , Johnston Alexander , Kotnik Emilee , Siemieniak David R. , Xu Jishu , Li Jun Z. , Saunders Thomas L. , Ginsburg David 
Published: October 2016

AbstractFactor V Leiden (F5L) is a common genetic risk factor for venous thromboembolism in humans. We conducted a sensitized ENU mutagenesis screen for dominant thrombosuppressor genes based on perinatal lethal thrombosis in mice homozygous forF5L(F5L/L) and haploinsufficient for tissue factor pathway inhibitor (Tfpi+/−).F8deficiency enhanced survival ofF5L/LTfpi+/−mice, demonstrating thatF5L/LTfpi+/−lethality is genetically suppressible. ENU-mutagenizedF5L/Lmales andF5L/+Tfpi+/−females were crossed to generate 6,729 progeny, with 98F5L/LTfpi+/−offspring surviving until weaning. Sixteen lines exhibited transmission of a putative thrombosuppressor to subsequent generations, with these lines referred to asMF5L(Modifier ofFactor5 Leiden) 1-16. Linkage analysis inMF5L6identified a chromosome 3 locus containing the tissue factor gene (F3). Though no ENU-inducedF3mutation was identified, haploinsufficiency forF3(F3+/−) suppressedF5L/LTfpi+/−lethality. Whole exome sequencing inMF5L12identified anActr2gene point mutation (p.R258G) as the sole candidate. Inheritance of this variant is associated with suppression ofF5L/LTfpi+/−lethality (p=1.7x10−6), suggesting thatActr2p.R258Gis thrombosuppressive. CRISPR/Cas9 experiments to generate an independentActr2knockin/knockout demonstrated thatActr2haploinsufficiency is lethal, supporting a hypomorphic or gain of function mechanism of action forActr2p.R258G. Our findings identifyF8and theTfpi/F3axis as key regulators in determining thrombosis balance in the setting ofF5Land also suggest a novel role forActr2in this process.Significance StatementVenous thromboembolism (VTE) is a common disease characterized by the formation of inappropriate blood clots. Inheritance of specific genetic variants, such as the Factor V Leiden polymorphism, increases VTE susceptibility. However, only ~10% of people inheriting Factor V Leiden develop VTE, suggesting the involvement of other genes that are currently unknown. By inducing random genetic mutations into mice with a genetic predisposition to VTE, we identified two genomic regions that reduce VTE susceptibility. The first includes the gene for blood coagulation Factor 3 and its role was confirmed by analyzing mice with an independent mutation in this gene. The second contains a mutation in the Actr2 gene. These findings identify critical genes for the regulation of blood clotting risk.
How we transmit memories to other brains: constructing shared neural representations via communication
Authors: Zadbood A. , Chen J. , Leong Y.C. , Norman K.A. , Hasson U. 
Published: October 2016

AbstractHumans are able to mentally construct an episode when listening to another person’s recollection, even though they themselves did not experience the events. However, it is unknown how strongly the neural patterns elicited by mental construction resemble those found in the brain of the individual who experienced the original events. Using fMRI and a verbal communication task, we traced how neural patterns associated with viewing specific scenes in a movie are encoded, recalled, and then transferred to a group of naïve listeners. By comparing neural patterns across the three conditions, we report, for the first time, that event-specific neural patterns observed in the default mode network are shared across the encoding, recall, and construction of the same real-life episode. This study uncovers the intimate correspondences between memory encoding and event construction, and highlights the essential role our common language plays in the process of transmitting one's memories to other brains.
Pervasive adaptation inPlasmodium-interacting proteins in mammals
Authors: Ebel Emily R. , Telis Natalie , Venkataram Sandeep , Petrov Dmitri A. , Enard David 
Published: October 2016

AbstractThe protozoan genusPlasmodiumcauses malaria in dozens of mammal species, including humans, non-human primates, rodents, and bats. In humans,Plasmodiuminfections have caused hundreds of millions of documented deaths, imposing strong selection on certain populations and driving the emergence of several resistance alleles. Over the deep timescale of mammalian evolution, however, little is known about host adaptation toPlasmodium. In this work, we expand the collection of knownPlasmodium-interacting-proteins (PIPs) in mammalian hosts from ~10 to 410, by manually curating thousands of scientific abstracts. We use comparative tests of adaptation to show that PIPs have experienced >3 times more positive selection than similar mammalian proteins, consistent withPlasmodiumas a major and long-standing selective pressure. PIP adaptation is strongly linked to gene expression in the blood, liver, and lung, all of which are clinically relevant tissues inPlasmodiuminfection. Interestingly, we find that PIPs with immune functions are especially enriched for additional interactions with viruses or bacteria, which together drive a 3.7-fold excess of adaptation. These pleiotropic interactions with unrelated pathogens, along with pressure from otherPlasmodium-like Apicomplexan parasites, may help explain the PIP adaptation we observe in all clades of the mammalian tree. As a case study, we also show that alpha-spectrin, the major membrane component of mammalian red blood cells, has experienced accelerated adaptation in domains known to interact specifically withPlasmodiumproteins. Similar interactions withPlasmodium-like parasites appear to have driven substantial adaptation in hundreds of host proteins throughout mammalian evolution.
Family firms in Ibero-America: an introduction
Authors: José Parada Maria , Müller Claudio , Gimeno Alberto 
Published: October 2016

PurposeThis paper highlights the importance of understanding family firms in different contexts. The purpose of this paper is to reflect on the characteristics and behavior of family firms in Ibero-America, and their contribution and fit to the broader field of research. Based on the five articles in this special issue, this paper attempts to give an overview of their main contributions.Design/methodology/approachThis paper explains in a contextual and analytical way the contributions of five papers that focus their attention on Ibero-American family firms, by linking them to the current research in the field and finding their fit within the broader field of family business. Tackling different topics, these five papers discuss about the comparison between family vs non-family businesses, innovation in family firms, and governance in family firmsFindingsFindings suggest that there is a need to stimulate research in family business in Ibero-America, especially Latin America, regarding family business dynamics, the different roles of the family within the enterprise, family governance, and the role of women. With regards to innovation the cultural and economic context play an important role in how they perform innovative activities.Originality/valueThis paper contributes to further understanding family firms by discussing the importance of the context and by linking all five papers with the broader literature in family business. The introduction also discusses topics worth to be further researched in Ibero-America.
Open innovation search strategies in family and non-family SMEs
Authors: Basco Rodrigo , Calabrò Andrea 
Published: October 2016

PurposeThe purpose of this paper is to investigate what types of open innovation search strategies are associated with internal innovation activities in family and non-family SMEs within natural resource-based clusters.Design/methodology/approachThis study is based on an empirical analysis of a sample of 245 Chilean firms.FindingsResults suggest that while family and non-family SMEs do not significantly differ in terms of internal innovation activities, important differences exist in terms of open innovation search strategies. In particular, family SMEs search for new ideas and knowledge within their closest network of relationships (e.g. customers, suppliers and competitors), whereas non-family SMEs mainly focus on broader network relationships (e.g. universities, public institutions and fair trade organizations).Practical implicationsThis study shows that within a natural resource cluster, the types of firm do matter. In fact, family and non-family SMEs use different open innovation search strategies to innovate; hence, this research may help and assist policy makers in tailoring innovation policies aimed at expanding the potential benefits of clusters for regional growth and development.Originality/valueThis research addresses the call to further investigate the link between family SMEs and innovation in developing countries, given that SMEs may also act as a lively player for regional development.
Management capability and performance in Spanish family firms
Authors: Garcés-Galdeano Lucia , García-Olaverri Carmen , Huerta Emilio 
Published: October 2016

PurposeThe purpose of this paper is to explore the possible causes of the heterogeneous productivity observed in Spanish firms, finding evidence of a link between managerial capability and higher productivity in the context of family firms. Also, innovative human resource policies are much more frequently found in companies where there is a high level of management capability.Design/methodology/approachProductivity differences in Spanish family firms are, for the first time, analysed from a managerial view, and using multiple correspondence analysis (MCA).FindingsThis paper proposes a way to measure managerial capability. Innovative human resource policies are much more frequently found in companies with high levels of management capability. The authors show that sustained competitive advantage is not just a function of single or isolated components, but rather a combination of human capital elements. Besides, a clear association between high managerial capability and performance in family firms is established. Thus, better management skills enable Spanish family firms to design the necessary strategies and internal structures to facilitate their adjustment to the business environment, and, thereby, achieve operational performance gains.Originality/valueThis paper proposes a way to measure managerial capability and its association with productivity in Spanish family firms using MCA. The authors also show a clear positive association between high managerial capability and performance in family firms. Thus, better management skills enable Spanish family firms to achieve operational performance gains.
Global research on air pollution between 2005 and 2014: a bibliometric study
Authors: Kolle Shankar Reddy , Thyavanahalli Shankarappa H. 
Published: October 2016

Purpose
The purpose of this paper is to analyze research works on air pollution published in 2005-2014 and indexed in Web of Science Core Collection.

Design/methodology/approach
The data of research publications on “air pollution” from the Web of Science Core Collection database were collected with following search strategy: publications with terms “Air contaminat*”, “Air pollut*”, “pollut* air” or “contaminat* air” in their titles for the period of 2005-2014 were collected. A total of 4,424 articles were published on air pollution during the period of 2005-2014, and the data were used for creation of database in Microsoft Excel for the analysis purpose. Bibliometric analysis techniques were applied wherever necessary.

Findings
Out of 4,424 articles published on air pollution in different languages, 4,276 articles were in English. The years 2013 and 2014 showed rapid increase in number of articles published, 563 and 638, respectively. The increased number of articles resulted in an increase in number of pages published and references cited in the articles. The articles published in the year 2006 had received more number of citations (12,318), and the average citation per article for the period was 17.59. Environmental Science was the major Web of Science subject category under which a greater number of articles were published. Article entitled as “Health effects of fine particulate air pollution: Lines that connect”, published in Journal of The Air & Waste Management Association by Pope and Dockery (2006), was the highest cited article (1,743) for the period, and the top most active journals that published huge number of articles were Atmospheric Environment and Environmental Health Perspective, with 11.79 per cent of the total articles (4,424) published.

Research limitations/implications
The findings of the study are limited to the journals covered under Web of Science Core Collection database and articles having the following keywords in their titles: “Air contaminat*”, “Air pollut*”, “pollut* air” or “contaminat* air”.

Originality/value
This study would be useful to researchers and policy makers to get an insight into the research trends of air pollution for effective decision-making and formulation of new research proposals.