bluuebunny/crossref_metadata_2025_split huggingface dataset:
Larval species composition and genetic structures ofCarposina sasakii,Grapholita dimorpha, andGrapholita molestafrom Korea
Authors: Kwon D.H. , Kwon H.K. , Kim D.H. , Yang C.Y. 
Published: July 2017

AbstractRapid determination of the larval species composition and understanding of their genetic structure is important to establish the appropriate management system for multiple species infesting in fruits. We established accurate and rapid diagnostic methods based on multiplex polymerase chain reaction (PCR) diagnostic techniques to discriminate the three major lepidopteran species in orchard,Carposina sasakii,Grapholita dimorpha, andGrapholita molesta. Each species was identified by amplifying species-specific PCR products (375 bp forC. sasakii, 125 and 234 bp forG. dimorpha, and 125 bp forG. molesta). Based on species composition analysis from six types of infested fruits,G. dimorphaconstituted the highest proportion (47.8%), followed by 35.2 and 13.5% forG. molestaandC. sasakii, respectively. Interestingly, high prevalence was found inG. dimorphaandG. molestafor plum and peach, respectively. Based on genetic diversity analysis, the three insect species exhibited moderate or high haplotype diversity and low nucleotide diversity, ranging from 0.319 to 0.699 and 0.0006 to 0.0045, respectively. Demographic expansion was not detected according to either a neutrality test or mismatch distribution analysis. Moreover, no significant genetic structure corresponding to province, host plant, fruit type, or collection period was observed. These results suggest that the population of each species would have high dispersal ability following fruit-generating periods via intrinsic host adaptation ability regardless of the spatial and temporal conditions. Determination of larval composition on fruit is valuable for establishing appropriate management systems that take the species into consideration; additionally, population genetic approaches can be utilized to understand the effects of environmental factors (province, host fruit, fruit type, etc.) on population structures.
Eustachian tube dysfunction leading to middle-ear pathology in patients on chronic mechanical ventilation
Authors: Ilan O , Marcus E-L , Cohen Y , Farkash T , Levy R , Sasson A , Adelman C 
Published: July 2017

AbstractObjective:This study aimed to investigate the prevalence of and risk factors for Eustachian tube dysfunction leading to middle-ear pathology in patients on chronic mechanical ventilation via tracheostomy tube.Methods:A total of 40 patients on chronic ventilation were included in a prospective cohort study. Middle-ear status was determined by tympanometry. Tympanograms were categorised as types A, B or C; types B and C were defined as middle-ear pathology.Results:In all, 57 ears of 40 patients were examined. Disease was found in at least 1 ear in 26 out of 40 patients. Middle-ear pathology was found in 25 out of 34 patients who were tube fed (via nasogastric tube or percutaneous endoscopic gastrostomy)vs1 patient out of the 6 fed orally (p= 0.014), and in 23 out of 31 with conscious or cognitive impairmentvs3 out of 9 cognitively intact patients (p= 0.044).Conclusion:Middle-ear pathology is common in patients on chronic mechanical ventilation via tracheostomy tube. The highest prevalence was in those with impaired consciousness or cognition, and oral feeding appeared protective.
PARTIAL LIABILITY
Authors: Kaiserman Alex 
Published: July 2017

AbstractIn most cases, liability in tort law isall-or-nothing—a defendant is either fully liable or not at all liable for a claimant's loss. By contrast, this paper defends a causal theory ofpartialliability. I argue that a defendant should be held liable for a claimant's loss only to the degree to which the defendant's wrongdoing contributed to the causing of the loss. I ground this principle in a conception of tort law as a system of corrective justice and use it to critically evaluate different mechanisms for “limiting” liability for consequences of wrongdoing and for “apportioning” liability between multiple wrongdoers.
Is food store type associated with the consumption of ultra-processed food and drink products in Brazil?
Authors: Machado Priscila Pereira , Claro Rafael Moreira , Martins Ana Paula Bortoletto , Costa Janaína Calu , Levy Renata Bertazzi 
Published: July 2017

AbstractObjectiveTo analyse the association between food store type and the consumption of ultra-processed products in Brazil.DesignData from the 2008–2009 Household Budget Survey involving a probabilistic sample of 55 970 Brazilian households. Food stores were grouped into nine categories. Foods and drinks were grouped according to characteristics of food processing. The contribution of each food store type to the total energy acquired from each food processing group, and according to quintiles of consumption of ultra-processed products, was estimated. Exploratory factor analysis was conducted to identify a pattern of food store usage. Linear regression models were performed to estimate the relationship between the purchase pattern and the consumption of ultra-processed products.ResultsIn line with their larger market share, supermarkets accounted for 59 % of total energy and participated most in acquisition for three food groups, with emphasis on ultra-processed products (60·4 % of energy). The participation of supermarkets in total purchase tended to increase in populations with higher consumption of ultra-processed products, while the participation of small markets and small producers tended to decrease. The purchase pattern characterized by use of traditional retail (street fairs and vendors, small markets, small farmers, butcheries) was associated with a smaller consumption of ultra-processed products.ConclusionsFood policies and interventions aiming to reduce the consumption of ultra-processed products should consider the influence of supermarkets on the consumption of these products. A purchase pattern based on traditional retail constitutes an important tool for promoting healthy eating in Brazil.
Hexagonal boron nitride nanomechanical resonators with spatially visualized motion
Authors: Zheng Xu-Qian , Lee Jaesung , Feng Philip X.-L. 
Published: July 2017

AbstractAtomic layers of hexagonal boron nitride (h-BN) crystal are excellent candidates for structural materials as enabling ultrathin, two-dimensional (2D) nanoelectromechanical systems (NEMS) due to the outstanding mechanical properties and very wide bandgap (5.9 eV) of h-BN. In this work, we report the experimental demonstration of h-BN 2D nanomechanical resonators vibrating at high and very high frequencies (from ~5 to ~70 MHz), and investigations of the elastic properties of h-BN by measuring the multimode resonant behavior of these devices. First, we demonstrate a dry-transferred doubly clamped h-BN membrane with ~6.7 nm thickness, the thinnest h-BN resonator known to date. In addition, we fabricate circular drumhead h-BN resonators with thicknesses ranging from ~9 to 292 nm, from which we measure up to eight resonance modes in the range of ~18 to 35 MHz. Combining measurements and modeling of the rich multimode resonances, we resolve h-BN’s elastic behavior, including the transition from membrane to disk regime, with built-in tension ranging from 0.02 to 2 N m−1. The Young’s modulus of h-BN is determined to be EY≈392 GPa from the measured resonances. The ultrasensitive measurements further reveal subtle structural characteristics and mechanical properties of the suspended h-BN diaphragms, including anisotropic built-in tension and bulging, thus suggesting guidelines on how these effects can be exploited for engineering multimode resonant functions in 2D NEMS transducers.
Dynamically induced robust phonon transport and chiral cooling in an optomechanical system
Authors: Kim Seunghwi , Xu Xunnong , Taylor Jacob M. , Bahl Gaurav 
Published: July 2017

AbstractThe transport of sound and heat, in the form of phonons, can be limited by disorder-induced scattering. In electronic and optical settings the introduction of chiral transport, in which carrier propagation exhibits parity asymmetry, can remove elastic backscattering and provides robustness against disorder. However, suppression of disorder-induced scattering has never been demonstrated in non-topological phononic systems. Here we experimentally demonstrate a path for achieving robust phonon transport in the presence of material disorder, by explicitly inducing chirality through parity-selective optomechanical coupling. We show that asymmetric optical pumping of a symmetric resonator enables a dramatic chiral cooling of clockwise and counterclockwise phonons, while simultaneously suppressing the hidden action of disorder. Surprisingly, this passive mechanism is also accompanied by a chiral reduction in heat load leading to optical cooling of the mechanics without added damping, an effect that has no optical analog. This technique can potentially improve upon the fundamental thermal limits of resonant mechanical sensors, which cannot be attained through sideband cooling.
Light-absorbing organic carbon from prescribed and laboratory biomass burning and gasoline vehicle emissions
Authors: Xie Mingjie , Hays Michael D. , Holder Amara L. 
Published: July 2017

AbstractLight-absorbing organic carbon (OC), also termed brown carbon (BrC), from laboratory-based biomass burning (BB) has been studied intensively to understand the contribution of BB to radiative forcing. However, relatively few measurements have been conducted on field-based BB and even fewer measurements have examined BrC from anthropogenic combustion sources like motor vehicle emissions. In this work, the light absorption of methanol-extractable OC from prescribed and laboratory BB and gasoline vehicle emissions was examined using spectrophotometry. The light absorption of methanol extracts showed a strong wavelength dependence for both BB and gasoline vehicle emissions. The mass absorption coefficients at 365 nm (MAC365, m2 g−1C) – used as a measurement proxy for BrC – were significantly correlated (p < 0.05) to the elemental carbon (EC)/OC ratios when examined by each BB fuel type. No significant correlation was observed when pooling fuels, indicating that both burn conditions and fuel types may impact BB BrC characteristics. The average MAC365 of gasoline vehicle emission samples is 0.62 ± 0.76 m2 g−1C, which is similar in magnitude to the BB samples (1.27 ± 0.76 m2 g−1C). These results suggest that in addition to BB, gasoline vehicle emissions may also be an important BrC source in urban areas.
Direct transfer of classical non-separable states into hybrid entangled two photon states
Authors: Jabir M. V. , Apurv Chaitanya N. , Mathew Manoj , Samanta G. K. 
Published: July 2017

AbstractHybrid entangled states, having entanglement between different degrees-of-freedom (DoF) of a particle pair, are of great interest for quantum information science and communication protocols. Among different DoFs, the hybrid entangled states encoded with polarization and orbital angular momentum (OAM) allow the generation of qubit-qudit entangled states, macroscopic entanglement with very high quanta of OAM and improvement in angular resolution in remote sensing. Till date, such hybrid entangled states are generated by using a high-fidelity polarization entangled states and subsequent imprinting of chosen amount of OAM using suitable mode converters such as spatial light modulator in complicated experimental schemes. Given that the entangled sources have feeble number of photons, loss of photons during imprinting of OAM using diffractive optical elements limits the use of such hybrid states for practical applications. Here we report, on a simple generic experimental scheme to generate hybrid entangled states in polarization and OAM through direct transfer of classical non-separable states of the pump beam in parametric down conversion process. As a proof of principle, using local non-separable pump states of OAM mode l = 3, we have produced quantum hybrid entangled states with entanglement witness parameter of ~1.25 ± 0.03 violating by 8 standard deviation.
Schematic eye-gaze cues influence infants’ object encoding dependent on their contrast polarity
Authors: Michel Christine , Pauen Sabina , Hoehl Stefanie 
Published: July 2017

AbstractWe examined infants’ sensitivity to eye-gaze direction and its influence on object processing in 4-month-old infants by manipulating low-level properties of gaze cues. Infants were presented with two kinds of stimuli that either did or did not cue novel objects. The movement of a schematic image of two eyes (two black circles each moving on a white oval background) led to an enhanced processing of the cued object. A cue with reversed polarity (two white circles each moving on a black oval background) elicited distinctly weaker effects. Results highlight infants’ specific sensitivity to isolated eye gaze which furthermore facilitates object encoding. It is suggested that this sensitivity relies on the typical perceptual pattern of eyes, the black pupil on a white sclera.
Cell Dispersal Influences Tumor Heterogeneity and Introduces a Bias in NGS Data Interpretation
Authors: Pongor Lőrinc , Harami-Papp Hajnalka , Méhes Előd , Czirók András , Győrffy Balázs 
Published: July 2017

AbstractShort and long distance cell dispersal can have a marked effect on tumor structure, high cellular motility could lead to faster cell mixing and lower observable intratumor heterogeneity. Here we evaluated a model for cell mixing that investigates how short-range dispersal and cell turnover will account for mutational proportions. We show that cancer cells can penetrate neighboring and distinct areas in a matter of days. In next generation sequencing runs, higher proportions of a given cell line generated frequencies with higher precision, while mixtures with lower amounts of each cell line had lower precision manifesting in higher standard deviations. When multiple cell lines were co-cultured, cellular movement altered observed mutation frequency by up to 18.5%. We propose that some of the shared mutations detected at low allele frequencies represent highly motile clones that appear in multiple regions of a tumor owing to dispersion throughout the tumor. In brief, cell movement will lead to a significant technical (sampling) bias when using next generation sequencing to determine clonal composition. A possible solution to this drawback would be to radically decrease detection thresholds and increase coverage in NGS analyses.
Stable isotopes of carbon and nitrogen help to predict the belowground communities at a regional scale
Authors: Wang Bing , Wu Ying , Chen Dima 
Published: July 2017

AbstractAt the regional scale, although environmental factors are known to shape the distributions of belowground communities in terrestrial ecosystems, these environmental factors account for relatively low percentages of the variation in belowground communities. More of this variation might be explained by considering ecosystem stable isotopic values, which can provide insight into environmental conditions. Here, we investigated ecosystem (plant and soil) δ13C and δ15N values and belowground communities (microbes and nematodes) as well as environmental factors (climates, soils, and plants) across the Mongolian Plateau. The regression analyses showed that plant isotopic values were more closely associated with belowground communities than soil isotopic values, while ecosystem δ13C values were more closely associated with the belowground communities than ecosystem δ15N values. We also found isotopic values were more closely associated with nematode communities than microbial communities. Variation partioning analyses indicated that environmental variables together explained 16–45% of total variation in belowground communities. After isotopic variables were added as predictors to the variation partition analyses, the explanation of the variance was improved by14–24% for microbial communities and was improved by 23–44% for nematode communities. These findings indicate that isotopic values could be used to predict the properties of belowground communities at a regional scale.
Huaier extract restrains the proliferative potential of endocrine-resistant breast cancer cells through increased ATM by suppressing miR-203
Authors: Gao Sumei , Li Xiaoyan , Ding Xia , Jiang Liyu , Yang Qifeng 
Published: July 2017

AbstractEndocrine therapy is one of the main treatments for breast cancer patients in the early stages. Tamoxifen and fulvestrant are the major drugs of endocrine therapy for breast cancer patients. However, acquired drug resistance often caused treatment failure and relapse for patients, which is a major clinical problem. We investigated whether Huaier extract had effects on endocrine-resistant breast cancer cells. In our study, we aimed to demonstrate the inhibitory effects of Huaier extract on tamoxifen-resistant cells (M7-TR) and fulvestrant-resistant cells (M7-FR). Using MTT and clone formation assays, we found that Huaier extract could inhibit the proliferation in M7-TR and M7-FR cells. Flow cytometry and western blotting illustrated that Huaier extract could induce G0/G1 arrest in both endocrine-resistant breast cancer cells. Mechanistically, we present that Huaier extract significantly increased ataxia telangiectasia mutation (ATM) via down-regulation of miR-203. Huaier extract also had the inhibitory effects on tumour growth in vivo in a xenograft mouse model. These results demonstrated that Huaier extract could inhibit the proliferation of M7-TR and M7-FR cells by increasing ATM via suppression of miR-203.
Shape dependent cytotoxicity of PLGA-PEG nanoparticles on human cells
Authors: Zhang Bokai , Sai Lung Ping , Zhao Saisai , Chu Zhiqin , Chrzanowski Wojciech , Li Quan 
Published: July 2017

AbstractWe investigated the influence of nanoparticles’ shape on the physiological responses of cells, when they were fed with spherical and needle-shaped PLGA-PEG nanoparticles (the volume of the nanoparticles had been chosen as the fixed parameter). We found that both types of NPs entered cells via endocytosis and upon internalization they stayed in membrane bounded vesicles. Needle-shaped, but not the spherical-shaped NPs were found to induce significant cytotoxicity in the cell lines tested. Our study evidenced that the cytotoxicity of needle-shaped NPs was induced through the lysosome disruption. Lysosome damage activated the signaling pathways for cell apoptosis, and eventually caused DNA fragmentation and cell death. The present work showed that physiological response of the cells can be very different when the shape of the fed nanoparticles changed from spherical to needle-like. The finding suggests that the toxicity of nanomaterials also depends on their shape.
Continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation
Authors: Imai Hirohiko , Yoshimura Hironobu , Kimura Atsuomi , Fujiwara Hideaki 
Published: July 2017

AbstractWe present a new method for the continuous flow production of concentrated hyperpolarized xenon-129 (HP 129Xe) gas from a dilute xenon (Xe) gas mixture with high nuclear spin polarization. A low vapor pressure (i.e., high boiling-point) gas was introduced as an alternative to molecular nitrogen (N2), which is the conventional quenching gas for generating HP 129Xe via Rb-Xe spin-exchange optical-pumping (SEOP). In contrast to the generally used method of extraction by freezing Xe after the SEOP process, the quenching gas separated as a liquid at moderately low temperature so that Xe was maintained in its gaseous state, allowing the continuous delivery of highly polarized concentrated Xe gas. We selected isobutene as the candidate quenching gas and our method was demonstrated experimentally while comparing its performance with N2. Isobutene could be liquefied and removed from the Xe gas mixture using a cold trap, and the concentrated HP 129Xe gas exhibited a significantly enhanced nuclear magnetic resonance (NMR) signal. Although the system requires further optimization depending on the intended purpose, our approach presented here could provide a simple means for performing NMR or magnetic resonance imaging (MRI) measurements continuously using HP 129Xe with improved sensitivity.
Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ
Authors: Solé-Morata Neus , Villaescusa Patricia , García-Fernández Carla , Font-Porterias Neus , Illescas María José , Valverde Laura , Tassi Francesca , Ghirotto Silvia , Férec Claude , Rouault Karen , Jiménez-Moreno Susana , Martínez-Jarreta Begoña , Pinheiro Maria Fátima , Zarrabeitia María T. , Carracedo Ángel , de Pancorbo Marian M. , Calafell Francesc 
Published: July 2017

AbstractHaplogroup R1b-M269 comprises most Western European Y chromosomes; of its main branches, R1b-DF27 is by far the least known, and it appears to be highly prevalent only in Iberia. We have genotyped 1072 R1b-DF27 chromosomes for six additional SNPs and 17 Y-STRs in population samples from Spain, Portugal and France in order to further characterize this lineage and, in particular, to ascertain the time and place where it originated, as well as its subsequent dynamics. We found that R1b-DF27 is present in frequencies ~40% in Iberian populations and up to 70% in Basques, but it drops quickly to 6–20% in France. Overall, the age of R1b-DF27 is estimated at ~4,200 years ago, at the transition between the Neolithic and the Bronze Age, when the Y chromosome landscape of W Europe was thoroughly remodeled. In spite of its high frequency in Basques, Y-STR internal diversity of R1b-DF27 is lower there, and results in more recent age estimates; NE Iberia is the most likely place of origin of DF27. Subhaplogroup frequencies within R1b-DF27 are geographically structured, and show domains that are reminiscent of the pre-Roman Celtic/Iberian division, or of the medieval Christian kingdoms.
Development and validation of a new comorbidity index for patients with head and neck squamous cell carcinoma in Japan
Authors: Takenaka Yukinori , Takemoto Norihiko , Oya Ryohei , Ashida Naoki , Kitamura Takahiro , Shimizu Kotaro , Takemura Kazuya , Michiba Takahiro , Hanamoto Atsushi , Suzuki Motoyuki , Yamamoto Yoshifumi , Uno Atsuhiko , Inohara Hidenori 
Published: July 2017

AbstractDue to habitual drinking and smoking and advanced age at diagnosis, patients with head and neck squamous cell carcinoma (HNSCC) frequently present with comorbidities. Several comorbidity indices have been developed and validated for HNSCC. However, none have become the standard method. In this study, we developed a new comorbidity index for Japanese patients with HNSCC, which was validated against an independent data set. A Cox proportional hazards analysis of 698 patients identified dementia, connective tissue diseases, and second primary malignancies in the oesophagus, head and neck, lungs, and stomach as prognostic comorbidities for overall survival. The Osaka head and neck comorbidity index (OHNCI) was generated from the weighted points of these comorbidities. In the independent data set, the 5-year overall survival rates for the low, moderate, and high scoring OHNCI groups were 62.1%, 64.3%, and 37.7%, respectively. In the multivariate analysis, the high scoring OHNCI group was an independent prognostic factor for overall survival (hazard ratio: 1.81, 95% confidence interval: 1.05–3.13; P = 0.031). The model including the OHNCI exhibited a higher prognostic capability compared to those including other commonly used comorbidity indices. The OHNCI could become the primary choice for comorbidity assessment in patients with HNSCC in Japan.