bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of the long-term application of QuikClot Combat Gauze, ChitoGauze PRO and Celox Gauze in a femoral artery injury model in swine – a preliminary study
Authors: Otrocka-Domagała I. , Jastrzębski P. , Adamiak Z. , Paździor-Czapula K. , Gesek M. , Mikiewicz M. , Rotkiewicz T. 
Published: August 2016

AbstractThe purpose of this study was to examine the safety of the long-term application of QuikClot Combat Gauze, ChitoGauze PRO and Celox Gauze using a swine model. The study was conducted on nine pigs weighing approximately 30 kg, which were randomly divided into three groups. Under deep anesthesia, the pigs underwent complete transverse cutting of the femoral artery in the groin region. Hemostatic dressings were left in the wound for 24 hours. The animals were euthanized 24 hours after dressing application. In each group, macroscopic and microscopic severe changes and shock symptoms were observed in the lungs, liver, kidneys and heart. Fibrino-gaseous embolic material was found in the pulmonary artery of each group and in the lung vessels of the animals from the ChitoGauze PRO and Celox Gauze groups. In conclusion, the long-term application of the evaluated hemostatic dressings has the risk of coagulopathy and reaching the progressive stage of shock. The residues from the hemostatic dressings can ingress into the systemic circulation, thereby increasing the risk of embolus formation. Because of these harmful effects, the evaluated hemostatic dressings are not appropriate for long-term use. Future studies are needed on the consequences of the long-term application of these hemostatic agents.
Analysis of the Genetic Diversity and Population Structure of Latvian Ash (Fraxinus excelsior L.) Stands using Nuclear and Chloroplast SSR Markers
Authors: Ruņģis Dainis , Korica Anna , Gailīte Agnese , Pušpure Ilze , Veinberga Ilze 
Published: August 2016

Abstract
Common ash (Fraxinus excelsior L.) has a widespread distribution throughout Europe, and Latvia is almost at the north eastern edge of the distribution range. In Europe, ash is threatened by ash dieback, a disease caused by the introduced ascomycete Hymenoscyphus fraxineus. Chloroplast and nuclear DNA markers have been used to study the genetic diversity and population structure of ash both in a broader pan-European context as well as in more restricted regions. Some of the markers analysed in these previously published reports were also utilised in this study, enabling comparisons of the genetic parameters calculated from the nuclear SSR marker data and of the haplotypes identified with the chloroplast markers. Analysis of chloroplast markers revealed one dominant haplotype in Latvian stands, which corresponds to the haplotype previously found in Eastern Europe and Scandinavia. A second haplotype, corresponding to a previously reported central European haplotype was found in all individuals from the Ķemeri stand, indicating that this stand was naturally established from introduced germplasm, which was planted in a neighbouring park. The nuclear SSR markers revealed low levels of differentiation of Latvian F. excelsior stands, probably due efficient pollen flow between stands. The analysis of both chloroplast and nuclear DNA markers has revealed different aspects of the structure and provenance of Latvian F. excelsior populations.
Ernährung: Universelle Prävention in der stationären Pflege
Authors: Blättner Beate 
Published: August 2016

Zusammenfassung:
Pflegekassen sollen künftig unter Beteiligung der versicherten Pflegebedürftigen und der Pflegeeinrichtungen Leistungen zur Prävention in stationären Pflegeeinrichtungen erbringen. Ein Handlungsfeld ist Ernährung. Im Nationalen Gesundheitsziel „gesund älter werden“ wird die Umsetzung des Qualitätsstandards für die Verpflegung in stationären Senioreneinrichtungen der Deutschen Gesellschaft für Ernährung empfohlen. Dieser ist allerdings nicht in seiner Evidenz überprüft und sieht keine partizipativen Ansätze vor.
Förderung der Qualität der Verpflegung in Kindertageseinrichtungen – Erfahrungen und Ergebnisse aus zwei Bremer Beratungsprojekten
Authors: von Atens-Kahlenberg Wiebke , Bosche Heidegret , Zeeb Hajo , Pischke Claudia R. 
Published: August 2016

Zusammenfassung:
Im Rahmen einer Fachberatung in Ernährungsfragen, die das Leibniz-Institut für Präventionsforschung und Epidemiologie (BIPS) für zwei große Bremer Träger von Kindertageseinrichtungen (Kita‘n) durchführt, wurden trägerbezogene Verpflegungskonzepte entwickelt. Sie beinhalten Qualitätsanforderungen und Empfehlungen unter anderem für das Verpflegungsangebot, die Mahlzeitengestaltung und die räumlichen Gegebenheiten für die Vorbereitung oder Lieferung der Mahlzeiten. Eines der Ergebnisse der Evaluation dieser Verpflegungskonzepte war, dass mehr als 80% der Kita‘n beider Träger die Vorgaben für einen ausgewogenen Speiseplan für 2–6-Jährige umsetzen.
Correlation between the expressions of leptin and its receptors (ObR,sObR) in gastric cancer / Mide kanserinde leptin ve reseptörlerinin (ObR, sObR) ekspresyonları arasındaki korelasyon
Authors: Çakır Işıl , Kılıç Eser , Coşkun Banu Demet Özel , Çakır Nuri , Savaşcıhabeş Asuman 
Published: August 2016

Abstract
Objective: The expressions of leptin and its receptor (ObR) have been observed in human gastric cancer (GC) tissue. Leptin can promote the proliferation of GC cells. However, the correlation between leptin and ObR expressions in GC and the role of gastric ObR protein levels in patients with GC is still unclear. This study aimed to evaluate the relationship between leptin, gastric ObR protein and soluble leptin receptor (sObR) levels and whether their possible role of indicator in GC.
Methods: Serum leptin, gastric leptin and serum sObR concentrations were determined in 30 male patients with GC and 25 male dyspeptic subjects by enzyme linked immunosorbent assay. We analysed the expression of gastric ObR levels in endoscopically obtained biopsy samples by using Western Blotting method.
Results: Compared with controls, patients had lower serum leptin and higher gastric tissue leptin levels. sObR protein concentrations of patients were detected significantly higher, gastric ObR protein expression were lower than subjects in control group.
Conclusion: Leptin in gastric cancerous region and sObR in circulation are overexpressed in GC. Their expressions are associated with malignancy. Decreased leptin levels, induces the sObR signal in circulation. This negative feedback regulation is also seen in gastric tissue: increased gastric tissue leptin levels inhibits gastric ObR protein expression. Thus,leptin and ObR may be important indicators in GC.
The association of sialic acid levels with nitric oxide and C-reactive protein in patients with diabetic foot ulcer / Diyabetik ayak ülseri olan hastalarda sialik asit düzeylerinin nitrik oksit ve C-reaktif protein ile ilişkisi
Authors: Keti Didem Barlak , Muhtaroğlu Sabahattin , Ünlühızarcı Kürşad , Çetin İhsan 
Published: August 2016

Abstract
Objective: The present study aimed to evaluate the association of serum sialic acid (SA) levels with nitric oxide (NO) and C-reactive protein (CRP) in patients with diabetic foot ulcer.
Methods: This study included total 56 type 2 diabetic patients (27 of them had diabetic foot ulcer and 29 without it) and 22 healthy volunteers. Serum SA, NO and CRP levels were measured with spectrophotometric and nephelometric methods respectively.
Results: Serum SA levels were higher in diabetic foot group than diabetes group (p<0.05). CRP and NO levels were found to be significantly higher in diabetic foot group compared to the diabetes (p<0.001 and p=0.002, respectively) and control groups (p<0.001, both). Although there was no correlation between SA and NO (p>0.05), serum SA levels were significantly correlated with CRP in diabetic foot group (p<0.001).
Conclusion: We suggest that SA could be related to acute phase response in patients with diabetic foot ulcer. Elevated serum SA and NO levels may be indicators of oxidative stress-induced vascular damage.
Effects of jinggangmycin on peroxidase and esterase isozymes and phytotoxin from Rhizoctonia solani AG-1 IA, the causal agent of rice sheath blight. Pirinç kabuğu yanığı nedeni Rhizoctonia solani AG-1 IA tarafından üretilen peroksidaz, esteraz izozimleri ve fitotoksinler üzerinde jinggangmycin etkisi
Authors: Yang Ying-Qing , Li Ming-Hai , Yang Mei , Shu Can-Wei , Li Xiang-Min , Lan Bo , Jian Yan-Li , Zhou Er-Xun 
Published: August 2016

Abstract
Objective: To explore the effects of jinggangmycin on the pathogenicity of rice sheath blight.
Methods: The effects of jinggangmycin on peroxidase and esterase isozymes from Rhizoctonia solani Kuhn AG-1 IA were compared using non-denaturing polyacrylamide gel electrophoresis (PAGE). Rs-toxins were obtained from the improved Richard medium amended with jinggangmycin at different concentrations. Subsequently, bioassays of Rs-toxin, including virulence to rice tissues, seedling wilting and inhibition to the seed germination were conducted.
Results: The results of PAGE showed that when the jinggangmycin concentration increased to 50 μg/mL, two of peroxidase isozyme bands became apparently weaker compared with the controls, indicating that jinggangmycin could considerably weaken the activity of the peroxidase isozyme. In addition, three extra bands of esterase isozyme were induced by jinggangmycin when the concentration increased to 50 μg/mL, indicating that jinggangmycin could affect the metabolism of esterase isozyme. The bioassays of Rs-toxin showed that jinggangmycin could weaken the virulence of Rs-toxin in rice tissues.
Conclusion: It was concluded that the control role of jinggangmycin in rice sheath blight might be due to the effects of jinggangmycin on the peroxidase and esterase isozymes and Rs-toxin virulence.
Nickel‐smelting fumes increased the expression of HIF‐1α through PI3K/ERK pathway in NIH/3T3 cells
Authors: Han Dan , Yang Yue , Zhang Lin , Wang Chao , Wang Yue , Tan Wen‐Qiao , Hu Xue‐Ying , Wu Yong‐Hui 
Published: August 2016

ObjectiveThe purpose of this study was to investigate the effects of Nickel (Ni)‐smelting fumes on oncogenic proteins in vivo and in vitro.MethodsNi fallout beside a Ni smelting furnace in a factory was sampled to study its toxic effect. The effects of Ni‐smelting fumes on the regulation of PI3K and ERK signaling pathways and the important downstream hypoxia inducible factor, HIF‐1α, were studied both in NIH/3T3 cells and in the lung tissue of rats. NIH/3T3 cell transformation induced by Ni‐smelting fumes was also observed.ResultsNi‐smelting fumes activated PI3K, p‐AKT, p70S6K 1, and ERK proteins and increased HIF‐1α expression in a time‐and dose‐dependent manner. However, activation was suppressed when NIH / 3 T 3 cells were pretreated with PI 3 K / AKT or ERK inhibitors. Ni‐smelting fumes caused malignant transformation of NIH/3T3 cells.ConclusionsNi‐smelting fumes increased the expression of HIF‐1α through the PI3K/ERK pathway in NIH/ 3T3 cells and induced malignant transformation in these cells indicating that Ni‐smelting fumes may be a potential carcinogen in mammalian cells.
Investigation of rare chronic lipoid pneumonia associated with occupational exposure to paraffin aerosol
Authors: Han Chenghong , Liu Lihai , Du Shiping , Mei Jianhua , Huang Ling , Chen Min , Lei Yongliang , Qian Junwen , Luo Jianyong , Zhang Meibian 
Published: August 2016

ObjectivesOccupational exposure to paraffin is an infrequent cause of lipoid pneumonia (LP) and related data are scare. We investigated the possible relationship between three rare cases of chronic LP and occupational exposure to paraffin aerosol in an iron foundry.MethodsThe three cases of LP and their workplaces were investigated using data from field investigations, air monitoring, pulmonary radiological examinations, cell staining, and lung biopsies.ResultsThe patients had long‐term occupational exposure to paraffin. X‐ray diffraction testing revealed that the raw material from the workshop was paraffin crystal. The air concentrations of paraffin aerosol in workplaces were significantly higher than outdoor background levels. Small diffuse and miliary shadows with unclear edges were observed throughout the whole lungs via radiography. Computed tomography revealed diffuse punctate nodules and a high density of stripe‐like shadows in both lungs (ground‐glass opacity in a lower lobe, and a masslike lesion and high translucent area near the bottom of the lung). Lipid‐laden macrophages were found in the sputum and bronchial lavage. A broadened alveolar septum and local focal fibrosis were also discovered via lung biopsy. The inflammatory reaction in the lung tissues appeared to resolve over time.ConclusionsThese three rare cases of chronic LP in workers during molding and repair processes were associated with occupational paraffin aerosol exposure. Therefore, primary prevention is essential for molding or repairing workers in the iron foundry, and a differential diagnosis of occupational chronic LP (vs. pneumoconiosis) should be considered when treating these workers.
Cost-Benefit Analysis of Three-Dimensional Craniofacial Models for Midfacial Distraction: a Pilot Study
Authors: Rogers-Vizena Carolyn R. , Flath Sporn Susan , Daniels Kimberly M. , Padwa Bonnie L. , Weinstock Peter 
Published: August 2016

Objective Patient-specific three-dimensional (3D) models are increasingly used to virtually plan rare surgical procedures, providing opportunity for preoperative preparation, better understanding of individual anatomy, and implant prefabrication. The purpose of this study was to assess the benefit of 3D models related to patient safety, operative time, and cost. Design Retrospective review. Setting Academic, tertiary care hospital. Patients, Participants Midfacial distraction was studied as a representative craniofacial operation. A consecutive series of 29 patients who underwent a single type of midfacial distraction was included. Intervention For a subset of patients, computed tomography-derived 3D models were used to study patient-specific anatomy and precontour hardware. Main Outcome Measures Complications, operative time, blood loss, and estimated cost. Results Twenty patients underwent midfacial distraction without and nine with preoperative use of a 3D model. Seven complications occurred in six patients without model use, including premature consolidation (3), cerebrospinal fluid leak (2), and hardware malfunction (2). No complications were reported in the model group. Controlling for surgeon variation, model use resulted in a 31.3-minute (7.8%) reduction in operative time. Time-based cost savings were estimated to be $1036. Conclusions Three-dimensional models are valuable for preoperative planning and hardware precontouring in craniofacial surgery, with potential positive effects on complications and operative time. Savings related to operative time and complications may offset much of the cost of the model.
Is Salvage Liver Resection Necessary for Initially Unresectable Hepatocellular Carcinoma Patients Downstaged by Transarterial Chemoembolization? Ten Years of Experience
Authors: Zhang Yingqiang , Huang Guihua , Wang Yu , Liang Lijian , Peng Baogang , Fan Wenzhe , Yang Jianyong , Huang Yonghui , Yao Wang , Li Jiaping 
Published: August 2016

Abstract

Introduction.
This study evaluated long-term outcomes of salvage surgery as additional therapy following downstaging of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) in patients with initially unresectable HCC.

Methods.
A retrospective analysis was performed of 831 consecutive patients with unresectable HCC who underwent TACE as initial treatment between June 2004 and December 2014. Of these, 82 patients with downstaged resectable HCC were enrolled in this study: 43 received salvage surgery (S group) and the remaining 39, who refused salvage resection, were the control group (T group). The primary endpoint was overall survival (OS).

Results.
The median OS in the S and T groups was 49 and 31 months, respectively (p = .027). The 2-, 4-, and 5-year survival rates were 93%, 47%, and 26% in the S group and 74%, 18%, and 10% in the T group, respectively (p = .019). Treatment modality (hazard ratio [HR], 0.337; 95% confidential interval [CI], 0.184–0.616; p &lt; .001) and response to TACE (complete vs. partial; HR, 3.154; 95% CI, 1.709–5.822; p &lt; .001) were independent prognostic factors for survival. The median OS for patients in the complete response and partial response (PR) subgroups was 50 and 49 months, respectively, in the S group and 54 and 24 months, respectively, in the T group (p = .699 and p &lt; .001, respectively). The median OS for HCC patients with macroscopic vascular invasion (MVI) was 58 and 30 months in the S and T groups, respectively (p = .024).

Conclusion.
Salvage surgery after downstaging of unresectable HCC had a survival benefit only for patients with MVI or a PR to TACE.
Shaking table tests on a three-storey timber building
Authors: Tomasi Roberto , Casagrande Daniele , Grossi Paolo , Sartori Tiziano 
Published: August 2016

This paper reports on a shaking table test conducted on a timber-framed building sheathed with oriented strand board within the framework of the European Series project at the National Laboratory of Civil Engineering in Lisbon, Portugal. The test structure was a full-scale, three-storey, 7 m × 5 m plan building. The aim of the tests was to assess the integrity of the structural members and the non-structural components during a seismic event. The structural design was carried out in accordance with European standards. The input signals comprised ‘accelerograms’, which were scaled versions of those recorded during the Montenegro (1979) and Tohoku (2011) earthquakes. The outcome of the tests showed excellent seismic behaviour, as demonstrated by the fact that the structure frequency did not change until the last step of the procedure. Moreover, after 17 simulations, no visible damage was detected.
Influence of Taekwondo on Flexibility Development in Boys of Primary School Age
Authors: Санжарова Н. М. , Попова М. В. 
Published: August 2016

Research objective. To experimentally prove the effectiveness of the use of Taekwondo means for flexibility development in boys of primary school age. To solve the tasks set, the study used the following methods: analysis of scientific and methodical literature; pedagogical observation; pedagogical testing, methods of mathematical statistics.Conclusions. The level of flexibility development in the boys of primary school age attending taekwondo classes for 2.9 ± 0.8 years (experimental group) is significantly higher than that of their peers (control group) whose physical activity is limited to physical training classes at school and periodic training in sports clubs at school (p < 0.05 — p < 0.001).
Pengaruh Prestise Lokasi Tuturan Terhadap Ragam Bahasa Remaja Puteri dalam Percakapan Informal
Authors: Kurniawati - 
Published: August 2016

Penggunaan bahasa dipengaruhi oleh beberapa faktor, di antaranya adalah penutur, lawan tutur, lokasi, dan waktu terjadinya tuturan. Faktor‐faktor tersebut menyebabkan perbedaan penggunaan bahasa yang dikenal dengan sebutan variasi atau ragam bahasa.Ragam bahasa yang digunakan kelompok penutur remaja menunjukkan identitas diri mereka. Usia puber merupakan masa pencarian identitas bagi para remaja. Ragam bahasa merupakan salah satu identitas yang ada pada diri remaja, termasuk remaja puteri. Dalam penggunaan ragam bahasa, nilai prestise lokasi tuturan sangat menentukan pemilihan ragam bahasa yang mereka gunakan.
Strategi Pengajaran Bahasa Daerah (Sunda) Untuk Mahasiswa Nonsunda Di PGSD UPI Kampus Cibiru
Authors: Rohayati Etty 
Published: August 2016

<p>Abstrak </p><p>Sesuai pasal no. 36 UUD 1945 yang menekankan bahwa “Di daerah‐daerah yang mempunyai bahasa sendiri yang dipelihara oleh rakyatnya dengan baik‐baik (misalnya bahasa Jawa, Sunda, Madura dan sebagainya) bahasa‐bahasa itu akan dihormati dan dipelihara oleh negara, Bahasa‐bahasa itu pun merupakan sebagian dari budaya Nusantara” dan sejalan pula dengan rekomendasi UNESCO tahun 1999 tentang “Pemeliharaan Bahasa‐bahasa ibu” Salah satunya realisasi dipeliharanya bahasa daerah (Sunda) oleh pemerintah di Jawa Barat, jelas dengan adanya pengajaran bahasa Sunda dari mulai tingkat SD , SLTP, sebagian SMU/SMK, dan Pendidikan Bahasa dan Sastra di Perguruan Tinggi, misal UPI, UNPAD dan UNPAS. Begitu juga PGSD UPI Bandung Kampus Cibiru, telah kerjasama dalam pendidikan progran stara ‐1 (S‐1) dengan kabupaten Kaimana, Propinsi Irian. Dan diantara program pendidikan adanya pendidikan bahasa Daerah (Sunda), pada semester tiga sebanyak tiga SKS. Strategi pembelajaran yang dilaksanakan yaitu secara teoritis, analisis kanstrantif. Materi perkuliahan yang disampaikan yaitu sesuai dengan empat keterampilan berbahasa di antaranya menyimak secara teoritis mengenai hakekat, kedudukan dan fungsi bahasa daerah, berbicara disesuaikan dengan kebutuhan sehari‐hari (kontekstual dan fungsional), misalnya dialog; perkenalan, ucapan selamat, ucapan terima kasih dan minta maaf, perbandingan kata‐kata yang berhubungan dengan tubuh, struktur keluarga, peralatan dapur, peralatan pertanian dan pertukangan. Membaca, mengapresiasi dan membandingkan hasil karya sastra, menulis aksara Sunda. Evaluasi berupa UTS dan UAS, pengembangan materi berupa tugas‐tugas, yang hasilnya cukup memuaskan.</p><p>Key Word: Bahasa Daerah, Strategi pengajaran, Suku non‐Sunda</p>
Pendidikan Karakter Di Sekolah
Authors: Rohendi Edi 
Published: August 2016

<div data-canvas-width="37.777992156862744">Abstrak</div><div data-canvas-width="349.9150745098038">Pendidakan karakter tiba-tiba menjadi wacana hangat di dunia pendidikan</div><div data-canvas-width="192.08482352941172">IndonesiWa laupun gagasan ihwal karakter adalah gagasan tua setua sejarah</div><div data-canvas-width="183.39721568627448">pendidikan, namun kemunculan gagasan “pendidikan karakter “(character</div><div data-canvas-width="166.49467843137253">building)menginterupsi bangsa kita khususnya yang sedang melanda bangsa</div><div data-canvas-width="125.72036862745095">Indonesia. Masalah-masalah yang terjadi seperti kekerasan, korupsi, manipulasi,</div><div data-canvas-width="189.64785882352945">praktek-praktek kebohongan dalam dunia pendidikan mulai dari menyontek</div><div data-canvas-width="350.1398235294117">dalamujian sampai plagiat,kurang keteladanan dikalangan para pemimpin bangsa, dan sebagainya, sebenarnya menyangkut masalah karakter. Walaupun sudah terlambat dalam menerapkan pendidikan karakter disekolah, “But late than never”, masih banyak generasi kita para peserta didik yang duduk dibangku sekolah dan butuh pendidikan karakter agar dimasa depannya menjadi orang yang tidak hanya cerdas secara intelek tapi juga memiliki karakter. Dunia pendidikan diharapkan menjadi motor penggerak sebagaimana telah dikemukakan oleh Mendinas Muhammad Nuh dalam peringatan Hardiknas tahun</div><div data-canvas-width="191.87519215686277">2010 yang lalu bahwa “ Pembangunan dan Pendidikan Karakter menjadi keharusan karena pendidikan tidak hanya menjadikan peserta didik cerdas. Pendidikan juga untuk membangun budi pekerti dan sopan santun dalam kehidupan “. Batasan karakter berada dalam dua wilayah. Ia diyakini ada sebagai sifat fitri manusia, sementara pada sisi lain ia diyakini harus “dibentuk”melalui pendidikan , salah satunya melalui pendidikan karakter</div><div data-canvas-width="186.45098039215685">disekolah. Pelaksanaan Pendidikan karakter disekolah sebagai alternative</div><div data-canvas-width="169.75605882352934">dikemukakan dalam makalah ini adalah: melalui Pembidanan dengan formula 4M (mengetaqhui, mencintai, menginginkan dan mengerjakan, juga dengan metode pembiasaan . Selain itu melalui metode : mengajarkan, keteladanan, mmenentukan prioritas dan praksis prioriotas.</div><div data-canvas-width="169.75605882352934"> </div><div data-canvas-width="169.75605882352934">Kata Kunci : Pendidikian Karakter, pendidikan Akhlak dan pendidikan Moral. </div>