bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between HDAC9 gene polymorphisms and stroke risk in the Chinese population: A meta-analysis
Authors: Zhou Xin , Guan Tangming , Li Shuyuan , Jiao Zinan , Lu Xiaoshuang , Huang Xiaodi , Ji Yuhua , Ji Qiuhong 
Published: February 2017

AbstractSeveral recent genome-wide association studies (GWASs) have suggested that the histone deacetylase 9 (HDAC9) gene is associated with stroke, but the reliability of these findings remains controversial, particularly for the data derived from different ethnicities and geographical locations. Therefore, we performed a meta-analysis to explore the associations between HDAC9 polymorphisms and the risk of stroke in the Chinese population. All eligible case-control studies that met the search criteria were retrieved from multiple databases, and six case-control studies with a total of 2,356 stroke patients and 3,420 healthy controls were included. The pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to assess the strengths of the associations of 3 HDAC9 gene polymorphisms with stroke risk. Our results revealed statistically significant associations of the rs2107595 (T/C) polymorphism with an increased risk of stroke in the allele, codominant and dominant models. Additionally, the rs2389995 (G/A) polymorphism was found to be significantly associated with a decreased risk of stroke in all genetic models. In conclusion, this meta-analysis suggested that the T allele of rs2107595 in HDAC9 increases the risk of stroke but that the G allele of rs2389995 decreases the risk of stroke in the Chinese population.
Serum protein changes in a rat model of chronic pain show a correlation between animal and humans
Authors: Bellei Elisa , Vilella Antonietta , Monari Emanuela , Bergamini Stefania , Tomasi Aldo , Cuoghi Aurora , Guerzoni Simona , Manca Letizia , Zoli Michele , Pini Luigi Alberto 
Published: February 2017

AbstractIn previous works we showed the overexpression of some proteins in biological fluids from patients suffering chronic pain. In this proteomic study we analysed serum from a rat model of neuropathic pain obtained by the chronic constriction injury (CCI) of sciatic nerve, at two time intervals, 2 and 5 weeks after the insult, to find proteins involved in the expression or mediation of pain. Sham-operated and CCI rats were treated with saline or indomethacin. Two weeks after ligation, we identified three serum proteins overexpressed in CCI rats, two of which, alpha-1-macroglobulin and vitamin D-binding protein (VDBP), remained increased 5 weeks post-surgery; at this time interval, we found increased levels of further proteins, namely apolipoprotein A-I (APOA1), apolipoprotein E (APOE), prostaglandin-H2 D-isomerase (PTGDS) and transthyretin (TTR), that overlap the overexpressed proteins found in humans. Indomethacin treatment reversed the effects of ligation. The qPCR analysis showed that transcript levels of APOA1, APOE, PTGDS and VDBP were overexpressed in the lumbar spinal cord (origin of sciatic nerve), but not in the striatum (an unrelated brain region), of CCI rats treated with saline 5 weeks after surgery, demonstrating that the lumbar spinal cord is a possible source of these proteins.
Photon-phonon Interaction in a Microfiber Induced by Optical and Electrostrictive Forces
Authors: Shi Yun-chao , Luo Wei , Xu Fei , Lu Yan-qing 
Published: February 2017

AbstractStimulated Brillouin scattering (SBS) via electrostrictive force is a fundamental interaction between light and sound which limits the power in conventional optical fibers. The emergence of optical microfibers with subwavelength diameter, ultralight mass and an intense light field, provides a new platform for photon–phonon coupling, resulting in the radiation pressure mediated contribution of SBS. This study examines the optomechanical system in cylindrical coordinates, reveals the theoretically radiation pressure induced analogous, and demonstrates contrary effect compared with electrostrictive force in solid or hollow silica microfibers. The finding shows that the photon-phonon coupling, which is related to SBS, can be suppressed in a solid microfiber, and even be completely cancelled in a hollow microfiber.
Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation
Authors: Vendetti Frank P. , Leibowitz Brian J. , Barnes Jennifer , Schamus Sandy , Kiesel Brian F. , Abberbock Shira , Conrads Thomas , Clump David Andy , Cadogan Elaine , O’Connor Mark J. , Yu Jian , Beumer Jan H. , Bakkenist Christopher J. 
Published: February 2017

AbstractWe show that ATM kinase inhibition using AZ31 prior to 9 or 9.25 Gy total body irradiation (TBI) reduced median time to moribund in mice to 8 days. ATR kinase inhibition using AZD6738 prior to TBI did not reduce median time to moribund. The striking finding associated with ATM inhibition prior to TBI was increased crypt loss within the intestine epithelium. ATM inhibition reduced upregulation of p21, an inhibitor of cyclin-dependent kinases, and blocked G1 arrest after TBI thereby increasing the number of S phase cells in crypts in wild-type but not Cdkn1a(p21CIP/WAF1)−/− mice. In contrast, ATR inhibition increased upregulation of p21 after TBI. Thus, ATM activity is essential for p21-dependent arrest while ATR inhibition may potentiate arrest in crypt cells after TBI. Nevertheless, ATM inhibition reduced median time to moribund in Cdkn1a(p21CIP/WAF1)−/− mice after TBI. ATM inhibition also increased cell death in crypts at 4 h in Cdkn1a(p21CIP/WAF1)−/−, earlier than at 24 h in wild-type mice after TBI. In contrast, ATR inhibition decreased cell death in crypts in Cdkn1a(p21CIP/WAF1)−/− mice at 4 h after TBI. We conclude that ATM activity is essential for p21-dependent and p21-independent mechanisms that radioprotect intestinal crypts and that ATM inhibition promotes GI syndrome after TBI.
Dissecting the molecular structure of the Orion B cloud: insight from principal component analysis
Authors: Gratier Pierre , Bron Emeric , Gerin Maryvonne , Pety Jérôme , Guzman Viviana V. , Orkisz Jan , Bardeau Sébastien , Goicoechea Javier R. , Le Petit Franck , Liszt Harvey , Öberg Karin , Peretto Nicolas , Roueff Evelyne , Sievers Albrech , Tremblin Pascal 
Published: February 2017

Context.The combination of wideband receivers and spectrometers currently available in (sub-)millimeter observatories deliver wide-field hyperspectral imaging of the interstellar medium. Tens of spectral lines can be observed over degree wide fields in about 50 h. This wealth of data calls for restating the physical questions about the interstellar medium in statistical terms.Aims.We aim to gain information on the physical structure of the interstellar medium from a statistical analysis of many lines from different species over a large field of view, without requiring detailed radiative transfer or astrochemical modeling.Methods.We coupled a non-linear rescaling of the data with one of the simplest multivariate analysis methods, namely the principal component analysis, to decompose the observed signal into components that we interpret first qualitatively and then quantitatively based on our deep knowledge of the observed region and of the astrochemistry at play.Results.We identify three principal components, linear compositions of line brightness temperatures, that are correlated at various levels with the column density, the volume density and the UV radiation field.Conclusions.When sampling a sufficiently diverse mixture of physical parameters, it is possible to decompose the molecular emission in order to gain physical insight on the observed interstellar medium. This opens a new avenue for future studies of the interstellar medium.
Short-term stock assessment of Loligo gahi at the Falkland Islands: sequential use of stochastic biomass projection and stock depletion models
Authors: Roa-Ureta Rubén , Arkhipkin Alexander I. 
Published: February 2017

Abstract
Roa-Ureta, R. and Arkhipkin, A. I. 2007. Short-term stock assessment of Loligo gahi at the Falkland Islands: sequential use of stochastic biomass projection and stock depletion models – ICES Journal of Marine Science, 64, 3–17. Two short-term stock assessment models are combined to examine the pre-season, in-season, and post-season dynamics of the Loligo gahi fishery off the Falkland Islands over four consecutive fishing seasons. A stochastic biomass projection model (SBPM) projects a pre-season survey-based biomass estimate from the date of the survey to the start of the season. A stock depletion model (SDM) assesses in-season biomass from commercial daily catch-and-effort data. The SBPM projects the SDM biomass estimate at the end of the season to a post-season date of spawning. Combining the SBPM and the SDM helps to clarify the spatio-temporal functioning of the stock and to assess the comparability of survey- and fishery-based estimates of biomass. For the first 2005 season, projected length frequencies indicate two pulses of recruitment onto the fishing grounds. Survey-based projections of biomass were lower than equivalent fishery-based estimates. Over two surveys, the sex ratio was balanced, suggesting full recruitment of both sexes onto the fishing grounds, and the ratio of survey-projected to fishing-estimated biomass was constant. This constant is interpreted as a scaling factor between survey biomass and absolute biomass.
Energy and Angular Response of TL Dosemeters for Beta Ray Dosimetry
Authors: Christensen P. , Prokic M. 
Published: February 2017

Abstract
Measured data are presented showing the influence of detector thickness, filter thickness, and detector/filter geometry on the energy and angular response of a beta dosemeter. The investigation comprises different types of thermoluminescent detectors with Mylar filters of thicknesses ranging from 0 - 49 mg.cm-2. 147Pm, 204Tl and 90Y sources were used for the irradiations. The measurements were made by placing the detectors in depressions in a 1 cm thick Perspex phantom that was turned to obtain different irradiation angles. Comparative measurements were made with an extrapolation chamber. The results showed that thin TL detectors, e.g. graphite-mixed sintered MgB4O7:Dy pellets and the Vinten extremity dosemeter satisfy the requirement to measure Hs(0.07) with sufficient accuracy for use for personal monitoring for beta ray maximum energies above 0.2 MeV.
Beta Dosimetry, Different Solutions
Authors: Uchrin G. 
Published: February 2017

Abstract
Various types of thermoluminescence beta dosemeters have been used and compared for mixed beta-gamma radiation dose measurements. The dosemeters investigated include; graphite mixed MgB4O7 and LiF pellets; cold pressed 0.2 mm thick LiF detectors; a pair of LiF/TLD-100 chips and cold pressed LiF of various thicknesses; a pair of LiF TLD-100 hot pressed chips with the same thicknesses but different filtration, and a specially prepared sandwich type dosemeter. This latter is composed of two thermoluminescent detectors separated by a layer of material with poor thermal conductivity. The glow curve structure using an approriate heating cycle allows evaluation of the TL responses of the two detectors simultaneously. The dose contributions from beta and hard beta plus gamma radiation may be determined using such a sandwich type dosemeter. The main features of the dosemeter systems, such as glow curve structure, sensitivity, energy dependence, detection limit, discrimination ratio between beta and gamma dose and their applicability are given and discussed.
Fast Neutron TL Dosimetry by Knock-on Protons: Energy Deposition in Thin Dosemeter Layers
Authors: Chassende-Baroz Ph. , Braunlich P. , Tetzlaff W. , Gasiot J. 
Published: February 2017

Abstract
Thin layer dosemeters are suitable for rapid laser heating and for the detection of knock-on protons produced in hydrogenous materials by collisions with fast neutrons. In an attempt to establish the optimum design parameters for a fast neutron dosemeter based on such a proton radiator, we calculate the proton conversion efficiencies and the resulting normalised TL signals for CaSO4:Dy layers of various thicknesses. On the basis of the known neutron energy spectra of 252Cf, moderated 252Cf, and Pu-Be neutron sources, the generation of protons in polyethylene foils, placed in close contact with the TLD layer, and the energy deposited by these protons in the CaSO4:Dy layer are computed. The results are compared with experiments performed in mixed neutron-gamma fields with 9 mm2 spots of this TL phosphor on borosilicate glass substrates heated with a computer-controlled CO2 laser beam of uniform intensity profile.
A High Precision Silicon Diode Dosimetry System
Authors: Dixon R.L. 
Published: February 2017

Abstract
An integrating dosimetry system using a silicon diode detector for use in routine spot checks of radiation therapy treatment machines is described. The system is a micropower, battery operated, dosemeter with a digital dose readout. It can contain the results of two irradiations in memory for the life of the batteries (~4 months), and hence can be used to check the output of a treatment unit at a remote facility by mail in lieu of TLD, with the advantage over TLD of higher precision and an immediate digital readout so that it is much less labour intensive. The dosemeter is designed to be completely automatic (radiation reset) for ease of use by the radiographer/technician. Stability over a three year period on a 60Co treatment machine was ±0.35% standard deviation with all readings being within 1.2% of the initial reading.
Optically Stimulated Luminescence in MgS:Ce,Sm
Authors: Mathur V.K. , Gasiot J. , Abbundi R.J. , Brown M.D. 
Published: February 2017

Abstract
MgS:Ce,Sm has been investigated for optically stimulated luminescence (OSL) characteristics with a view to application in radiation dosimetry. Two dominant glow peaks, around 346 and 449K are observed in this material. The latter peak is suitable for dosimetry. This peak can be optically stimulated under 1317 nm irradiation from a InGaAsP diode laser subsequent to UV or ? ray dose. Optically stimulated luminescence follows the law IOSL=Iot-x, where x is approximately unity. Gamma ray dose relative to total light output of OSL exhibits a linear relationship between 1 and 10 Gy (100-1000 rad). Various observations suggest that the traps empty through the tunnelling of the carriers to Ce3+ recombination centres under optical stimulation.
The Localised Transition Model of Anomalous Fading
Authors: Templer R.H. 
Published: February 2017

Abstract
The currently accepted model for the anomalous fading of TL depends upon the quantum mechanical tunnelling of charge from deep traps to nearby recombination centres. Here a model is described which allows charge recombination to occur by transitions through an excited state common to a trap and luminescence centre pair. The theory is tested with respect to time and temperature for the anomalous fading in zircon and pumice. The results indicate that above room temperature localised transitions occur and at lower temperatures tunnelling predominates.
A Critical Analysis of Neutron RBE, Risk, and Q
Authors: Straume T. 
Published: February 2017

Abstract
The present neutron quality factor (Q) debate appears not to have focussed sufficiently on the implications of combining results obtained under vastly differing exposure conditions. The neutron RBEs that provide the basis for the recent ICRP and NCRP recommendations to increase neutron Q (from 10 to 20) were derived from experimental data obtained using low dose rate photons (fractionated or chronic-exposures) as the comparison radiation. In contrast, the dose limitation system within which the new quality factor would be used is based primarily on linear, non-threshold fits to high dose rate, mostly high dose, human epidemiological data. Combining such disparate data can be expected to over-estimate the neutron risk, perhaps even grossly. Rather than equalising risks for neutrons and gamma rays, the result could be the setting of unnecessarily restrictive neutron dose limits. It is proposed here that attempts be made to base both Q and estimates of human low LET risk coefficients on data obtained under similar irradiation conditions and using consistent dose response models. For example, if Q is to be based on RBEs obtained at low dose rates (RBEM), then the low LET risk coefficients for human stochastic effects should also be based on low dose rates. This, of course, would reduce low LET risk values, which are presently based on linear fits to high dose rate data. (Dose rate reduction factors of 5 to 10 are commonly observed experimentally). Or, because the effect of dose rate on human stochastic responses is largely unknown, it could be argued that application of the (perhaps conservative) linear, non-threshold model to the human epidemiological data should be continued for radiation protection purposes. In this case, Q should be based on RBEs that also are obtained from linear fits to low LET radiation data. Under these conditions, a Q somewhere between 5 and 10 would be consistent with experimental results.
A Neutron Survey Instrument Which Gives Information on the Low Energy Neutron Spectrum and Can be Used for Albedo Dosemeter Calibration
Authors: Harvey J.R. , Hart C.D. 
Published: February 2017

Abstract
An instrument has been developed for surveying neutron environments. It contains two thermal neutron detecting elements which consist of touch proof surface barrier detectors in contact with thin layers of 6LiF. One detector is located at the centre of a 76 mm (3") diameter Polythene sphere. The readings of the two detectors give information on the thermal and intermediate components of the ambient dose equivalent, and can be combined to mirror the response of various albedo dosemeters. The instrument can also be used to scale pulses from a wide energy range neutron survey instrument, and hence be used to assess the proportion of the neutron dose equivalent detected by albedo dosimetry systems.
Calculation of Dose Equivalent Index, Effective Dose Equivalent and Ambient Dose Equivalent for the Giant-Resonance Neutron Spectra Produced at an Electron Accelerator
Authors: Pelliccioni M. , Zanini A. 
Published: February 2017

Abstract
The results of calculations for the attenuation of the giant-resonance neutron spectra produced at an electron accelerator in various shielding materials are presented. As the spectra are similar to those of some radioactive sources, a comparison is made with Cf and Am-Be sources. Considering all the changes that have occurred in recent years regarding the quantities to be used in radiation protection, the results are expressed in terms of dose equivalent index, effective dose equivalent and ambient dose equivalent.
An Investigation of CR-39 Nuclear Track Detector Material as a Fast Neutron Microdosemeter
Authors: Stafford P.M. , Horton J.L. , Hogstrom K.R. , Johnson D.A. 
Published: February 2017

Abstract
This work describes the evaluation of CR-39 for use as a fast neutron microdosemeter, and provides some insight as to the feasibility of such use. The material was calibrated by irradiation with protons and alpha particles accelerated by a tandem electrostatic accelerator. Proton energies of 10, 6, and 3 MeV and alpha particle energies of 15, 10, and 7 MeV were used, at angles of incidence from 0 to 85 deg. The critical angle, normal incidence diameter, and track etching rates versus linear energy transfer (LET) were obtained from these measurements. A method for extracting a LET spectrum from CR-39 irradiated in-phantom with the fast neutron beam was developed and these results are compared with LET spectra measured by a 1.27 cm diameter Rossi chamber.
Response of Polyethylene Embedded TLDs to Neutrons from Some Polyenergetic Sources
Authors: Spurný F. , Luong D.T. , Votocková I. , Charvát J. , Gelev M. , Mishev I. 
Published: February 2017

Abstract
The responses of recently developed polyethylene embedded thermoluminescent detectors, TLDs, to neutrons from the polyenergetic sources 252Cf, PuBe and 9Be(d,n) with EN = 7.2 MeV were studied. The TL materials CaSO4:Dy, CaSO4:Mn and Al2O3 were used. The influence of an external proton radiator (polyethylene cover) on the relative response was also studied. It was found that relative responses increased substantially with both internal and external proton radiators. The enhancement depends not only on the neutron energy but also on the type of TLD. The results obtained are analysed and discussed.
Thermal Neutron Dosimetry with Cadmium Telluride Detectors
Authors: Fasasi M. , Jung M. , Siffert P. , Teissier C. 
Published: February 2017

Abstract
Cadmium telluride, a semiconductor compound with high Z is presently used at room temperature as a gamma ray detector. We have used this material to detect thermal neutrons by making use of the very high cross section of 113Cd to absorb thermal neutrons and emit gamma rays. Two CdTe detectors were exposed to a known thermal neutron beam at the CRN reactor, in order to analyse the performance of this device and a Monte Carlo code was developed to determine the expected response spectrum. For the two devices considered here under a series of experimental conditions, satisfactory agreement was observed between calculations and experimental data. Some of the 113Cd(n,?) radiative capture lines were identified by calibrating the detector with 57Co source. Since the atomic density of CdTe is much higher than in gas detectors, the efficiency under a small volume is very high, even if the total volume is presently limited to 10 x 10 x 2 mm3. In using CdTe as a thermal neutron dosemeter, it is best to use for calibration the line at 560 keV emitted and detected in the same device.
Analysis of Ground Fissures Using Content Ratios of Nuclides by Car-Borne Survey
Authors: Kimura S. 
Published: February 2017

Abstract
A new system was tested for car-borne and manual surveys of natural radiation to detect open fissures concealed in the ground. Positive deviation of the primary gamma ray dose ratio of 214Bi and 208Tl from its moving average was adopted as the main index. Localities where the positive deviation exceeded a threshold value gave a good indication of the existence of covered open fissures. The lowest of the deviations in a traverse was proportional to the amount of 222Rn ascending through fissures. This measurement system proved to be effective in prospecting for ground-water, hot springs, uranium, oil and natural gas resources and in earthquake prediction studies.
210Po in Marine Organisms: A Wide Range of Natural Radiation Dose Domains
Authors: Carvalho F.P. 
Published: February 2017

Abstract
Marine biota is able to concentrate 210Po to high levels, as 103-105 relative to sea water concentration. 210Po concentrations in mixed zooplankton reaches 34-51 Bq.kg-1 (fresh wt), special groups such as copepods reaching even higher concentrations ~90 Bq.kg-1, whereas gelatinous zooplankton display ~1 Bq.kg-1. Epipelagic teleosts feeding on plankton displayed the highest concentrations found in fish muscle, 2-21 Bq.kg-1. Contrasting with this, demersal teleosts and elasmobranchs display lower 210Po concentrations, in the ranges 0.5-7 Bq.kg-1 and 0.2-1.7 Bq.kg-1, respectively. Much higher concentrations can, however, be measured in fish liver, gonad, bone and piloric caecca, and small mesopelagic fish can reach ~800 Bq.kg-1 on a whole-body basis. Due to these 210Po activity concentrations, dose equivalent rates delivered to biological tissues in marine organisms can vary widely, from 0.4 mSv.y-1 in gelatinous plankton up to 5.6 x 103 mSv.y-1 in the gut wall of sardines. It is concluded that in organisms living in the same ocean layer a wide range of internal radiation doses exist and it is essentially sustained by 210Po food-chain transfer.