bluuebunny/crossref_metadata_2025_split huggingface dataset:
International sports federations as de facto lawmakers: Queer-feminist explorations of the gendered power of sports law
Authors: Holzer Lena 
Published: September 2024

AbstractThis article analyses the law-making power of international sports federations, with a specific focus on their authority of shaping global norms on gender. It explores a variety of international sporting rules from feminist and queer perspectives. These include the ban of rainbow armbands at the 2022 FIFA (Men’s) World Cup, rules on the participation of transgender persons in rugby, gendered and racialized uniform regulations in sports, and the Semenya case concerning the sports participation of women with variations in sex characteristics The analysis asserts that despite being non-state actors, international sports federations are de facto international lawmakers that disseminate hegemonic gender norms reflecting cis-hetero-sexism and white body norms. However, analysing the Semenya case and the decision of the Chamber of the European Court of Human Rights in the case shows that the law-making power of international sports federations in shaping gender norms is not absolute but embedded in a transnational network of norms. The article concludes that subjecting international sports federations to a feminist, queer, and anti-racist legal analysis assists in understanding how hegemonic norms on gender circulate transnationally and enhances knowledge on how international law works in practice.
Transcatheter occlusion of venovenous collaterals in the total cavopulmonary Fontan circulation
Authors: Baker David W. , Uthayakumaran Gajon , Polwart Ngaire , Lee Melissa G.Y. , Wilson Will , Ayer Julian , Tanous David , D’Udekem Yves , Celermajer David S. , O’Donnell Clare , Cordina Rachael 
Published: September 2024

AbstractBackground:Venovenous collaterals are abnormal connections between the systemic and pulmonary venous systems. They are commonly seen in the Fontan circulation and may lead to significant hypoxaemia. Transcatheter closure of venovenous collaterals is a potential but controversial treatment as the long-term benefits and outcomes are not well understood.Methods:This retrospective cohort study utilised data from the Australian and New Zealand Fontan Registry. Patients who underwent transcatheter venovenous collateral occlusion for hypoxemia from the year 2000 onwards were included. Atriopulmonary and Kawashima-type Fontan circulations were excluded to reflect a more contemporary Fontan cohort.Results:Nineteen patients (age 19.3 ± 7.8 years, 53% female) underwent transcatheter venovenous collateral occlusion. Compared to baseline, mean oxygen saturation was improved at latest follow-up (90.5% vs 87.0%; p = 0.003). Nine patients achieved a clinically significant response (defined as an increase of at least 5% to 90% or greater), and this was associated with lower baseline Fontan pressures (12.9 v 15.6 mmHg; p = 0.02). No heart failure hospitalisations, arrhythmia, transplant referrals, or mortality were observed during the median follow-up period of 4 years. Two patients experienced thromboembolic events and five patients underwent re-intervention.Conclusion:Transcatheter occlusion of venovenous collaterals in Fontan patients with chronic hypoxaemia resulted in a modest increase in oxygenation over a median follow-up of 4 years and longer-term prognosis did not appear to be adversely affected. Lower Fontan pressures at baseline were associated with a greater improvement in oxygenation.
Subjective fitness relates to performance and can be improved by exercise in children and young adults with heart disease
Authors: Aronoff Elizabeth B. , Chin Clifford , Opotowsky Alexander R. , Rice Malloree C. , Mays Wayne A. , Knecht Sandra K. , Goessling Jennah , Powell Adam W. 
Published: September 2024

AbstractIntroduction:The Duke Activity Status Index is used to assess an individual patient’s perception of their fitness abilities. It has been validated and shown to predict actual fitness in adults but has been studied less in the paediatric population, specifically those with heart disease. This study aims to assess if the Duke Activity Status Index is associated with measured markers of physical fitness in adolescents and young adults with heart disease.Methods:This retrospective single-centre cohort study includes patients who completed a minimum of 12 weeks of cardiac rehabilitation between 2016 and 2022. Cardiac rehabilitation outcomes included physical, performance, and psychosocial measures. A comparison between serial testing was performed using a paired t-test. Univariable and multivariable analyses for Duke Activity Status Index were performed. Data are reported as median [interquartile range].Results:Of the 118 participants (20 years-old [13.9–22.5], 53% male), 33 (28%) completed at least 12 weeks of cardiac rehabilitation. Median peak oxygen consumption was 60.1% predicted [49–72.8%], and Duke Activity Status Index was 32.6 [21.5–48.8]. On Pearson’s correlation assessing the Duke Activity Status Index, there were significant associations with % predicted peak oxygen consumption (r = 0.49, p < 0.0001), 6-minute walk distance (r = 0.45, p < 0.0001), Duke Activity Status Index metabolic equivalents (r = 0.45, p < 0.0001), and dominant hand grip (r = 0.48, p < 0.0001). In multivariable analysis, the % predicted peak oxygen consumption (r = 0.40, p = 0.005) and dominant hand grip (r = 0.37, p = 0.005) remained statistically significant.Conclusions:Duke Activity Status Index is associated with measures of physical fitness in paediatric and young adults with heart disease who complete a cardiac rehabilitation program.
Do immigrants at bay keep the xenophobes away? Post-entry rights and public opposition to immigrant admission
Authors: Lutz Philipp 
Published: September 2024

AbstractMany citizens in liberal democracies are concerned about immigration and its impact on their countries. Governments often seek to address these concerns by restricting the post-entry rights of immigrants such as the right to permanent settlement or access to welfare benefits. Thereby, it is expected that immigrants with an inferior legal status are (perceived as) less threatening to natives and, as a result, make the latter more willing to accept new immigrants. Does this policy rationale indeed attenuate public opposition to immigrant admission and thus allow for the reconciliation of the economic need for immigrants with the political concerns of domestic constituents? This study advances the theoretical argument of a rights-conditionality in citizens’ immigration preferences and provides empirical evidence on the phenomenon. A factorial survey experiment among citizens in the United States and Switzerland tests the effect of residence and welfare rights on the public opposition to immigrant admission. The results show that restricting immigrants’ welfare rights does significantly decrease public opposition towards immigration across the two countries. In contrast, restricting immigrants’ residence rights does not, and in the context of Switzerland, even increases opposition to immigrant admission. Citizens critical of immigration are thus not per se more welcoming to immigrants if they receive an inferior legal status but seem to care about immigrants’ contributions and commitment to the receiving society. The findings highlight the importance of immigrants‘ post-entry rights in the view of citizens and show how the design of immigration policies may help to understand public immigration preferences.
What militaries need to know about data protection and the right to digital privacy/private life
Authors: Argren Rigmor 
Published: September 2024

Abstract
With the advent of socio-technical systems that gather and process personal data, the capacity to identify and even locate people in an automated fashion has dramatically increased. This article discusses what militaries need to know about data protection and the right to digital privacy/private life when personal data is processed. The focus in this discussion is on sensitive data that makes individuals identifiable. It is here argued that the right to data protection and the right to digital privacy/private life are distinctive and separate rights and should be treated as such, despite some overlaps. Although the law of armed conflict approaches processing of sensitive data in a topical manner, it remains firm on the delimitation between what is permissible and what becomes unlawful when it comes to processing data. This article illustrates that elements of both data protection and protection of the right to privacy/private life can be traced in the law of armed conflict. In fact, both rights remain distinctive also in times of armed conflict and must be separately protected through obligations of result as well as obligations of conduct.
Embedding constitutional rights
Authors: Taylor Whitney K. 
Published: September 2024

AbstractThis article details the concept of constitutional embedding and demonstrates its utility in four country-rights cases. Constitutional embedding refers to the process by which some understanding of constitutional rights comes to take root in everyday life, moving from words on paper to something that shapes expectations and behavior. The degree of constitutional embedding varies along two dimensions: social and legal, or how individuals and groups operating in the social sphere understand and relate to constitutional rights, and how those working in the formal legal sphere do so. In a global political climate defined by democratic backsliding, powerful vested interests, and backlash against moves toward equality, the status of constitutional rights and how they become and remain embedded is doubly important. The constitutional embedding framework highlights how interactions between legal elites and ordinary citizens constitute the extent to which constitutional law influences daily life. The framework has broad applicability across contexts and rights domains.
Observational Insights of Nearshore Wind Stress and Parameterizations From Gaussian Process Regressions
Authors: Benbow C. A. , MacMahan J. H. 
Published: September 2024

AbstractThe nearshore wind stress, , is examined using machine‐learning models for air‐ocean data collected via new flux buoys deployed across four experiments. Consistent with prior nearshore studies, existing open‐ocean models predict nearshore with a large error of 0.0152 m2/s2. Gaussian Process Regression (GPR) for nearshore is developed, reducing errors to 0.0108 m2/s2. Nearshore air‐sea parameterizations are examined with wind speed (61%) and the wind‐wave frequency of encounters (16%) being the most important. A simpler nearshore, GPR‐derived, wind‐dependent‐only model () is developed, with errors of 0.0135 m2/s2. GPRs, evaluated using identical variables, were applied to nearshore observations, and these observations modeled with open‐ocean formulations for an initial comparison of parameterizations between these two regimes. The parameterizations are similar, though with subtle nonlinear differences. The new nearshore data set and machine‐learning models enhance the accuracy of predictions and understanding of differences from the open‐ocean.
Vapor Condensates on the Most Pristine Black Beads From a Clod in Apollo Drive Tube 73001: Discovery of Lunar NaCl Nanocrystals
Authors: Liu Yang , Ma Chi 
Published: September 2024

AbstractIdentification of the mineral species of vapor condensates on the surface of lunar pyroclastic beads, formed during the flights of beads in the lunar volcanic plume, helps to constrain the physical and chemical conditions of the lunar volcanic plume. We conducted nanomineralogy studies of vapor condensates on the surface of pristine black beads from a clod that was extracted from the recently opened Apollo drive tube 73001. This drive tube had been sealed under vacuum since its collection on the Moon and thus represents the most pristine sample in allocatable Apollo collection. Vapor condensates observed on the surface include patches made of ZnS nanocrystals and possible rare scattered NaCl nanocrystals. ZnS nanocrystals were previously found on Apollo 15 green and yellow beads, but NaCl nanocrystals are unique to black beads. Both ZnS and NaCl nanocrystals are absent in Apollo 17 74220 orange beads. Although orange and black beads are of similar chemistry, black beads in the clod 73001, 226 could form from a different environment.
Tectonic Anatomy Reveals the Chinese Altai‐Kuerti‐Dulate Arc Amalgamation in the Southern Altaids
Authors: Gan Jingmin , Xiao Wenjiao , Mao Qigui , Wang Hao , Sang Miao , Tan Zhou , Li Rui , Ao Songjian , Song Dongfang , Zhang Zhiyong 
Published: September 2024

AbstractThe Erqis tectonic belt, situated at the junction of the Chinese Altai‐East Junggar, originated through the subduction of the Ob‐Zaisan Ocean, playing a pivotal role in unraveling the tectonic evolution of the southern Altaids. Tectonic and provenance analyses discern three distinct arcs: the Chinese Altai in the north exhibits a protracted history from the late Cambrian to early Permian with a slender accretionary complex (AC) termed the Supute AC; the Kuerti intra‐oceanic arc in the middle emerged during the Silurian to Devonian coevally with a minor AC known as the Tesibahan AC; and the Dulate arc in the south predominantly evolved from the Middle Devonian to Permian, giving rise to the Fuyun AC that independently developed on its northern margin at least until ∼273 Ma. Our findings indicate the existence of multiple arcs within the Ob‐Zaisan Ocean, forming an archipelago paleogeography in the Paleo‐Asian Ocean. Provenance studies lead us to propose that cryptic sutures demarcating the Chinese Altai, Kuerti, and Dulate lie approximately along the Kuerti and Tesibahan faults, respectively, and that the oceanic branches between these arcs subducted northward beneath the Chinese Altai and Kuerti arcs and southward beneath the Dulate arc. Additionally, our work demonstrates the closure of the Ob‐Zaisan Ocean most probably postdates ∼273 Ma. Combining our data with previous research, we present a novel tectonic evolution model, elucidating several arc amalgamations with multiple subduction polarities between Chinese Altai and East Junggar throughout the late Cambrian to Permian.
The Changing Hydrology of an Irrigated and Dammed Yangtze River: Streamflow, Extremes, and Lake Hydrodynamics
Authors: Hao Haoran , Dong Ningpeng , Yang Mingxiang , Wei Jianhui , Zhang Xuejun , Xu Shiqin , Yan Denghua , Ren Liliang , Leng Guoyong , Chen Lu , Zhou Xudong , Wang Hao , Song Lijuan , Kunstmann Harald 
Published: September 2024

AbstractUnderstanding the role of anthropogenic activities in the hydrological cycle is critical to support sustainable water management for the Yangtze River Basin (YRB), which experiences extensive dam operation, irrigation and water withdrawal. However, this remains challenging due to insufficient accuracies of existing process‐based models for fully depicting anthropogenic activities as part of the hydrological cycle. To this end, this study enhances a national‐scale coupled land surface‐hydrologic‐hydrodynamic model (CLHMS) with a dynamic irrigation scheme for distinct crops, an extended reservoir operation scheme incorporating both water storage anomalies and water demand anomalies, and a cost‐function‐based approach to link water demands with reservoir operation. The enhanced model is extensively validated against historical streamflow, water storage of 90 reservoirs, and irrigation water withdrawal in the YRB, and the water level and storage of the Poyang Lake (PYL). By setting up controlled experiments in the YRB, we show that the streamflow decreases by 2%–6% due to irrigation and water withdrawal, and manifests an attenuated seasonality due to reservoir operation. At the basin scale, the increasing trend of extreme flood peaks exhibits a reversal under human activities, with the flood mitigation effect of irrigation and water withdrawal accounting for up to 50% of that of reservoir operation. The hydrodynamics of the PYL also exhibits considerable human‐induced alterations, with a 1.79 m‐decrease in the water level at the end of flood season. Our study sheds light on quantifying anthropogenic hydrologic impacts at basin scales, with important implications for understanding the co‐evolution between anthropogenic activities and the hydrological cycle.
Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway
Authors: A. Avelar Rita , Gupta Riya , Carvette Grace , da Veiga Leprevost Felipe , Jasti Medhasri , Colina Jose , Teitel Jessica , Nesvizhskii Alexey I. , O’Connor Caitlin M. , Hatzoglou Maria , Shenolikar Shirish , Arvan Peter , Narla Goutham , DiFeo Analisa 
Published: September 2024

AbstractThe integrated stress response (ISR) regulates cell fate during conditions of stress by leveraging the cell’s capacity to endure sustainable and efficient adaptive stress responses. Protein phosphatase 2A (PP2A) activity modulation has been shown to be successful in achieving both therapeutic efficacy and safety across various cancer models. However, the molecular mechanisms driving its selective antitumor effects remain unclear. Here, we show for the first time that ISR plasticity relies on PP2A activation to regulate drug response and dictate cellular survival under conditions of chronic stress. We demonstrate that genetic and chemical modulation of the PP2A leads to chronic proteolytic stress and triggers an ISR to dictate whether the cell lives or dies. More specifically, we uncovered that the PP2A-TFE3-ATF4 pathway governs ISR cell plasticity during endoplasmic reticular and cellular stress independent of the unfolded protein response. We further show that normal cells reprogram their genetic signatures to undergo ISR-mediated adaptation and homeostatic recovery thereby avoiding toxicity following PP2A-mediated stress. Conversely, oncogenic specific cytotoxicity induced by chemical modulation of PP2A is achieved by activating chronic and irreversible ISR in cancer cells. Our findings propose that a differential response to chemical modulation of PP2A is determined by intrinsic ISR plasticity, providing a novel biological vulnerability to selectively induce cancer cell death and improve targeted therapeutic efficacy.
Characterization of regulated cancer cell death pathways induced by the different modalities of non-thermal plasma treatment
Authors: Biscop Eline , Baroen Jana , De Backer Joey , Vanden Berghe Wim , Smits Evelien , Bogaerts Annemie , Lin Abraham 
Published: September 2024

AbstractNon-thermal plasma (NTP) has shown promising anti-cancer effects, but there is still limited knowledge about the underlying cell death mechanisms induced by NTP and inherent differences between NTP treatment modalities. This study aimed to investigate four major regulated cell death (RCD) pathways, namely apoptosis, pyroptosis, necroptosis, and ferroptosis, in melanoma cancer cells following NTP treatment, and to provide an overview of molecular mechanistic differences between direct and indirect NTP treatment modalities. To discriminate which cell death pathways were triggered after treatment, specific inhibitors of apoptosis, pyroptosis, necroptosis, and ferroptosis were evaluated. RCD-specific molecular pathways were further investigated to validate the findings with inhibitors. Both direct and indirect NTP treatment increased caspase 3/7 and annexin V expression, indicative of apoptosis, as well as lipid peroxidation, characteristic of ferroptosis. Pyroptosis, on the other hand, was only induced by direct NTP treatment, evidenced by increased caspase 1 activity, whereas necroptosis was stimulated in a cell line-dependent manner. These findings highlight the molecular differences and implications of direct and indirect NTP treatment for cancer therapy. Altogether, activation of multiple cell death pathways offers advantages in minimizing treatment resistance and enhancing therapeutic efficacy, particularly in a combination setting. Understanding the mechanisms underlying NTP-induced RCD will enable the development of strategic combination therapies targeting multiple pathways to achieve cancer lethality.
N6-methyladenosine-modified TRIM37 augments sunitinib resistance by promoting the ubiquitin-degradation of SmARCC2 and activating the Wnt signaling pathway in renal cell carcinoma
Authors: Luo Qiang , Dai Ting , Dong Yihong , Liang Jianpeng , Xu Zhipeng , Sun Zhixia 
Published: September 2024

AbstractTripartite motif-containing 37 (TRIM37) is reportedly a key member of the superfamily of TRIM proteins. Emerging evidence underscores the close association between dysregulated TRIM37 expression and the progression of various human malignancies. However, the precise biological functions and regulatory mechanisms of TRIM37 remain elusive. This study aimed to elucidate the impact of TRIM37 on the chemotherapy sensitivity of renal cell carcinoma (RCC) and uncover its specific molecular regulatory role. Using RT-qPCR and western blot assays, we assessed TRIM37 expression in both RCC patients and RCC cells. Through in vitro and in vivo experiments, we investigated the effects of TRIM37 silencing and overexpression on RCC cell proliferation, stemness capacity, and chemotherapy sensitivity using colony formation and sphere formation assays. Additionally, a co-immunoprecipitation (Co-IP) experiment was conducted to explore putative interacting proteins. Our results revealed elevated TRIM37 expression in both RCC patient tumor tissues and RCC cells. Functional experiments consistently demonstrated that TRIM37 silencing reduced proliferation and stemness capacity while enhancing chemotherapy sensitivity in RCC cells. Furthermore, we discovered that TRIM37 mediates the degradation of SMARCC2 via ubiquitin-proteasome pathways, thereby further activating the Wnt signaling pathway. In conclusion, this study not only sheds light on the biological role of TRIM37 in RCC progression but also identifies a potential molecular target for therapeutic intervention in RCC patients.