bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hearing Loss in Patients Who Received Cranial Radiation Therapy for Childhood Cancer
Authors: Bass Johnnie K. , Hua Chia-Ho , Huang Jie , Onar-Thomas Arzu , Ness Kirsten K. , Jones Skye , White Stephanie , Bhagat Shaum P. , Chang Kay W. , Merchant Thomas E. 
Published: January 2016

Purpose Patients treated with cranial radiation therapy (RT) are at risk for sensorineural hearing loss (SNHL). Although SNHL is often characterized as a delayed consequence of anticancer therapy, longitudinal reports of SNHL in childhood cancer survivors treated with contemporary RT are limited. We report the incidence, onset, severity, and long-term trajectory of SNHL among children receiving RT. Potential risk factors for SNHL were also identified. Patients and Methods Serial audiologic testing was conducted on 235 pediatric patients who were treated with conformal or intensity-modulated RT as part of an institutional phase II trial for localized primary brain tumors, including craniopharyngioma, ependymoma, and juvenile pilocytic astrocytoma. All but one patient had measurable cochlear radiation dose (CRD) greater than 0 Gy. The median follow-up from RT initiation to latest audiogram was 9 years with a median of 11 post-RT audiograms per patient. Audiograms were classified by the Chang Ototoxicity Grading Scale. Progression was defined by an increase in Chang grade from SNHL onset to the most recent evaluation. Results At last evaluation, SNHL was prevalent in 14% of patients: 2.1% had mild and 11.9% had significant SNHL requiring hearing aids. Median time from RT to SNHL onset was 3.6 years (range, 0.4 to 13.2 years). Among 29 patients with follow-up evaluations after SNHL onset, 65.5% experienced continued decline in hearing sensitivity in either ear and 34.5% had no change. Younger age at RT initiation (hazard ratio [HR], 2.32; 95% CI, 1.21 to 4.46), higher CRD (HR, 1.07; 95% CI, 1.03 to 1.11), and cerebrospinal fluid shunting (HR, 2.02; 95% CI, 1.07 to 3.78) were associated with SNHL. Conclusion SNHL is a late effect of RT that likely worsens over time. Long-term audiologic follow-up for a minimum of 10 years post-RT is recommended.
PROCLAIM: Randomized Phase III Trial of Pemetrexed-Cisplatin or Etoposide-Cisplatin Plus Thoracic Radiation Therapy Followed by Consolidation Chemotherapy in Locally Advanced Nonsquamous Non–Small-Cell Lung Cancer
Authors: Senan Suresh , Brade Anthony , Wang Lu-hua , Vansteenkiste Johan , Dakhil Shaker , Biesma Bonne , Martinez Aguillo Maite , Aerts Joachim , Govindan Ramaswamy , Rubio-Viqueira Belén , Lewanski Conrad , Gandara David , Choy Hak , Mok Tony , Hossain Anwar , Iscoe Neill , Treat Joseph , Koustenis Andrew , San Antonio Bélen , Chouaki Nadia , Vokes Everett 
Published: January 2016

Purpose The phase III PROCLAIM study evaluated overall survival (OS) of concurrent pemetrexed-cisplatin and thoracic radiation therapy (TRT) followed by consolidation pemetrexed, versus etoposide-cisplatin and TRT followed by nonpemetrexed doublet consolidation therapy. Patients and Methods Patients with stage IIIA/B unresectable nonsquamous non–small-cell lung cancer randomly received (1:1) pemetrexed 500 mg/m2 and cisplatin 75 mg/m2 intravenously every 3 weeks for three cycles plus concurrent TRT (60 to 66 Gy) followed by pemetrexed consolidation every 3 weeks for four cycles (arm A), or standard therapy with etoposide 50 mg/m2 and cisplatin 50 mg/m2 intravenously, every 4 weeks for two cycles plus concurrent TRT (60 to 66 Gy) followed by two cycles of consolidation platinum-based doublet chemotherapy (arm B). The primary objective was OS. The study was designed as a superiority trial with 80% power to detect an OS hazard ratio of 0.74 with a type 1 error of .05. Results Enrollment was stopped early because of futility. Five hundred ninety-eight patients were randomly assigned (301 to arm A, 297 to arm B) and 555 patients (283 in arm A, 272 in arm B) were treated. Arm A was not superior to arm B in terms of OS (hazard ratio, 0.98; 95% CI, 0.79 to 1.20; median, 26.8 v 25.0 months; P = .831). Arm A had a significantly lower incidence of any drug-related grade 3 to 4 adverse events (64.0% v 76.8%; P = .001), including neutropenia (24.4% v 44.5%; P < .001), during the overall treatment period. Conclusion Pemetrexed-cisplatin combined with TRT followed by consolidation pemetrexed was not superior to standard chemoradiotherapy for stage III unresectable nonsquamous non–small-cell lung cancer.
Hematopoietic Stem Cells Transplantation Can Normalize Thyroid Function in a Cystinosis Mouse Model
Authors: Gaide Chevronnay H. P. , Janssens V. , Van Der Smissen P. , Rocca C. J. , Liao X. H. , Refetoff S. , Pierreux C. E. , Cherqui S. , Courtoy P. J. 
Published: January 2016

Abstract
Hypothyroidism is the most frequent and earliest endocrine complication in cystinosis, a multisystemic lysosomal storage disease caused by defective transmembrane cystine transporter, cystinosin (CTNS gene). We recently demonstrated in Ctns−/− mice that altered thyroglobulin biosynthesis associated with endoplasmic reticulum stress, combined with defective lysosomal processing, caused hypothyroidism. In Ctns−/− kidney, hematopoietic stem cell (HSC) transplantation provides long-term functional and structural protection. Tissue repair involves transfer of cystinosin-bearing lysosomes from HSCs differentiated as F4/80 macrophages into deficient kidney tubular cells, via tunneling nanotubes that cross basement laminae. Here we evaluated the benefit of HSC transplantation for cystinotic thyroid and investigated the underlying mechanisms. HSC engraftment in Ctns−/− thyroid drastically decreased cystine accumulation, normalized the TSH level, and corrected the structure of a large fraction of thyrocytes. In the thyroid microenvironment, HSCs differentiated into a distinct, mixed macrophage/dendritic cell lineage expressing CD45 and major histocompatibility complex II but low CD11b and F4/80. Grafted HSCs closely apposed to follicles and produced tunneling nanotube-like extensions that crossed follicular basement laminae. HSCs themselves further squeezed into follicles, allowing extensive contact with thyrocytes, but did not transdifferentiate into Nkx2.1-expressing cells. Our observations revealed significant differences of basement lamina porosity between the thyroid and kidney and/or intrinsic macrophage invasive properties once in the thyroid microenvironment. The contrast between extensive thyrocyte protection and low HSC abundance at steady state suggests multiple sequential encounters and/or remanent impact. This is the first report demonstrating the potential of HSC transplantation to correct thyroid disease and supports a major multisystemic benefit of stem cell therapy for cystinosis.
Female-Femmeing: A Gender-Bent Performance Practice
Authors: Heller Meredith 
Published: January 2016

Abstract
It is common for female-identified individuals to perform feminine acts—what I term “female-femmeing”—at contemporary drag king and queer drag shows. Although some scholarship has acknowledged the presence of these acts, a woman’s onstage (and offstage) femininity is frequently considered nontransgressive, nonqueer, and not gender-bending. This article first interrogates why femininity is often presumed to mean social alignment, and then demonstrates how some femininities actively contest this. Pairing Muñoz’s characterization of disidentification with ethnography from drag shows in Los Angeles, San Francisco, and Oakland (2008–2012), I illustrate several ways female-femmeing bends or expands hegemonic femininity. These acts not only add complexity to a queer counterpublic drag space, but also, I suggest, encourage the consideration of all identities, including femininity, as potentially queer. The acceptance of female-femmeing as queer, and the expansion of drag narratives to meet these practices, is an important step toward a queer world ideology.
Two “Gaysian” Junior Faculty Talking about Experience: A Collaborative Autoethnography
Authors: Eguchi Shinsuke , Spieldenner Andrew 
Published: January 2016

Abstract
As junior faculty of color, we face multiple racialized, gendered, and class challenges in higher education. To explicate the nuances of junior faculty experiences, we explore and interrogate our embodied performances as “gaysian” (gay and Asian) through the framework of complex intersectionalities. We engage in embodied performance strategies such as silence and humor to navigate the hierarchy and engage critical pedagogy in the classroom. We argue that negotiating the hegemonic relations of power and privilege is a complicated process in the classroom with students.
Degradation of TiB2/TiC Composites in Liquid Nd and Molten NdF3–LiF–Nd2O3 System
Authors: Wang Huihua , Su Lijuan , Wang Deyong , Qu Tianpeng , Tu Ganfeng 
Published: January 2016

AbstractThe degradation of titanium diboride (TiB2)/titanium carbide (TiC) composites in the liquid Nd and molten NdF3–Nd2O3–LiF salts is investigated at 1,060 °C, respectively. The penetration of TiB2/TiC composites by liquid Nd mainly depended on the grain boundaries and residual pores, even if the coherent interface is formed between TiB2and TiC. The oxidation of TiB2led to further interfacial chemistry reactions, which speeded up the degradation of TiB2/TiC composites at the initial stage in NdF3–LiF–Nd2O3system. After that, the degradation was slowed because of the formation of diffusion boundary layer, and then chemical penetration was replaced gradually by the physical penetration. The dissolved Ti in liquid Nd and NdF3–LiF–Nd2O3melts are used to evaluate the corrosion rate of TiB2/TiC composites, and the calculated values were about 0.56 and 7.8 mm/year, respectively. After the penetration by liquid Nd and NdF3–LiF–Nd2O3melts, the bending strengths of TiB2/TiC composites decreased and the fracture mode changed from transgranular to intergranular due to the decreased grain boundary force.
Quantification and monetary valuation of urban ecosystem services in Munich, Germany
Authors: Aevermann Tim , Schmude Jürgen 
Published: January 2016

Abstract
Urban green spaces provide ecosystem services that can be used by the local population. The valuation of these ecosystem services in urban areas gives information for stakeholders and decision-makers to improve urban planning processes. In addition, this information can be used to provide a better understanding of how urban green spaces should be managed. In this study, we quantify and monetize four ecosystem services (carbon sequestration and storage, air pollution removal, runoff reduction, groundwater recharge) provided by the urban green space of Schlosspark Nymphenburg in Munich, Germany. We classify four different land cover types (tree, grass/herbaceous, water, impervious) to calculate different amounts of ecosystem services according to the land cover type. In addition, we quantify the maintenance costs which this urban green space causes to the city of Munich. The interpretation, communication and risks of valuations studies are discussed.
Differential Expression of Genes Involved in Host Recognition, Attachment, and Degradation in the Mycoparasite Tolypocladium ophioglossoides
Authors: Quandt C Alisha , Di Yanming , Elser Justin , Jaiswal Pankaj , Spatafora Joseph W 
Published: January 2016

Abstract
The ability of a fungus to infect novel hosts is dependent on changes in gene content, expression, or regulation. Examining gene expression under simulated host conditions can explore which genes may contribute to host jumping. Insect pathogenesis is the inferred ancestral character state for species of Tolypocladium, however several species are parasites of truffles, including Tolypocladium ophioglossoides. To identify potentially crucial genes in this interkingdom host switch, T. ophioglossoides was grown on four media conditions: media containing the inner and outer portions of its natural host (truffles of Elaphomyces), cuticles from an ancestral host (beetle), and a rich medium (Yeast Malt). Through high-throughput RNASeq of mRNA from these conditions, many differentially expressed genes were identified in the experiment. These included PTH11-related G-protein-coupled receptors (GPCRs) hypothesized to be involved in host recognition, and also found to be upregulated in insect pathogens. A divergent chitinase with a signal peptide was also found to be highly upregulated on media containing truffle tissue, suggesting an exogenous degradative activity in the presence of the truffle host. The adhesin gene, Mad1, was highly expressed on truffle media as well. A BiNGO analysis of overrepresented GO terms from genes expressed during each growth condition found that genes involved in redox reactions and transmembrane transport were the most overrepresented during T. ophioglossoides growth on truffle media, suggesting their importance in growth on fungal tissue as compared to other hosts and environments. Genes involved in secondary metabolism were most highly expressed during growth on insect tissue, suggesting that their products may not be necessary during parasitism of Elaphomyces. This study provides clues into understanding genetic mechanisms underlying the transition from insect to truffle parasitism.
SOCIOPOÉTICA E FORMAÇÃO DO PESQUISADOR INTEGRAL
Authors: Gauthier Jacques 
Published: January 2016

Ao considerar os limites cognitivos da entrevista e as relações de poder que caracterizam as pesquisas acadêmicas foi criada a sociopoética, voltada para a constituição de grupos-pesquisadores atores e sujeitos da pesquisa, com valorização das culturas populares e de resistência, mobilização do corpo inteiro como fonte de conhecimentos, utilização de técnicas artísticas de pesquisa e dialogicidade na interação entre a academia e as comunidades anfitriões da pesquisa. O autor justifica teoricamente essa abordagem e expõe os passos de realização de uma pesquisa, desde a negociação inicial até a socialização, insistindo sobre os diversos momentos, analíticos e intuitivos, sensíveis, emotivos e racionais da criação coletiva e cooperativa do conhecimento. Além de uma forte referência à filosofia de Deleuze e Guattari estão expostas técnicas e noções originais que, além dos problemas, conceitos e personagens conceituais que encontramos em obras filosóficas acadêmicas, caracterizam as pesquisas sociopoéticas.
O FUTURO DA PSICOLOGIA BRASILEIRA: uma questão de projeto político
Authors: Rechtman Raizel 
Published: January 2016

Este estudo tem como objetivo traçar algumas perspectivas sobre o futuro da psicologia brasileira. Para tanto, será apresentada uma análise histórica e política sobre o surgimento da psicologia no Brasil, o perfil e atuação da(o) psicóloga(o) e formação em psicologia em nosso país. A partir destas análises, torna-se clara a indissociabilidade entre formação, ciência e profissão, a influência do projeto de profissão na construção da psicologia e a necessidade de posicionamento da categoria em assumir o seu futuro.
AS PSICÓLOGAS NO SUAS: MOBILIZANDO RECURSOS PARA UMA ATUAÇÃO COM COMPROMISSO SOCIAL
Authors: Santos Luane Neves 
Published: January 2016

O presente artigo objetiva refletir sobre a inserção da psicologia na assistência social, buscando evidenciar recursos e elementos necessários para a constituição de uma atuação consolidada no “compromisso social”. Para tanto, discutirá a realidade social brasileira em seu caráter de forte desigualdade social, apresentando as condições históricas para a constituição do Sistema Único da Assistência Social (SUAS) enquanto política pública que intenciona o enfrentamento desse processo. Retomará a trajetória da construção da psicologia como ciência e profissão, na qual convivem projetos ético-políticos distintos, que valorizam o compromisso com as elites ou com a transformação da realidade social brasileira, e se expressam na formação do profissional, nutrindo valores e práticas diversas. Com base em pesquisa realizada com psicólogas que atuam no SUAS serão apresentadas reflexões acerca de recursos e elementos necessários para a constituição de uma atuação consistente na assistência social. Reflexões que: a) apontam para o reconhecimento da complexidade da atuação dessa profissional no SUAS, situando a importância da produção de novas metodologias de trabalho, principalmente aquelas que trabalham com dispositivos grupais; b) focam na formação interdisciplinar; c) enfatizam a importância da profissional produzir leituras críticas e complexas sobre a realidade social brasileira, marcada por forte desigualdade, considerando que os pensamentos são orientadores da ação e dos significados que as psicólogas constituem para explicar os fenômenos. Ou seja, na leitura da realidade que essas profissionais produzem, também se encontram os limites, as potencialidades, e por assim dizer, o horizonte no qual serão construídas as intervenções.
La protección de la potencia más feliz de la tierra...
Authors: Vázquez Olivera Mario 
Published: January 2016

<p>En este trabajo se examinan los esfuerzos del gobierno centroamericano , entre 1823 y 1826 , por establecer una alianza con el gobierno estadunidense ante las acechanzas de vecinos mas poderosos como México y Colombia que buscaban medrar a costa de la República Federal de Centroamerica para ensanchar sus territorios. Tales esfuerzos fracasaron debido al escaso interes de Washington por involucrarse en los conflictos Iimitrofes entre Ios nacientes paises hispanoamericanos.</p>
Peter A. Hargous y la TRC en 1852 o de cómo tratar de recuperar una concesión y fracasar en el intento
Authors: Suárez Argüello Ana Rosa 
Published: January 2016

<p>El artículo presenta a la Tehuantepec Railroad Compan y, empresa estadunidense que quiso construir una via de comunicación interoceánica en el istmo de Tehuantepec; refiere cómo sus propietarios lucharon por conservar la concesión que el Congreso de México había anulado , y revisa Los recursos que se emplearon para hacer ruido , obtener el apoyo del Senado y obligar a la administración de Millard Fillmore a intervenir en su favor</p>
Los estados confederados de América: carácter nacional y política exterior hacia México, 1861
Authors: Gurza Lavalle Gerardo 
Published: January 2016

<p>Al inicio de la guerra de secesón en Estados Unidos, los estados confederados trataron de legitimar su lucha independentista mediante la consagración de ciertos principios, valores y creencias que debían constituir la base Ideológica de la nueva nación. Esa ideología nacional ejerció una influencia considerable en la actuación de la efímera república sureña en la escena internacional y particularmente, en sus relaciones con México</p>
La mirada de Morrow sobre México: ¿preludio de la Buena Vecindad?
Authors: Collado Herrera María del Carmen 
Published: January 2016

<p>Se aborda la gestión diplomática de Dwight W. Morrow en México utilizando el enfoque de la historia cultural. Se pone énfasis en la percepción de este embajador sabre su vecino del sur como ingrediente para explicar el giro de las relaciones entre México y Estados Unidos. Se sostiene que su mirada de formó en las intersecciones del discurso del dominado y el dominante, en una etapa en que la contracultura estadunidense revaloraba "al otro", representado par el latinoamericano.</p>
México y las cruzadas anticomunistas estadunidenses, 1924-1964
Authors: Buchenau Jürgen 
Published: January 2016

<p>Este trabajo analiza la reacción mexicana ante las cruzadas anticomunistas de Estados Unidos durante tres episodios: la presidencia de Calles, la Guatemala de Arbenz, y el gobierno revolucionario de la Cuba de Castro. El tema permite analizar la intrigante paradoja de que, durante la guerra fría, un régimen anticomunista -producto de una revolución que el gobierno estadunidense calificó alguna vez de bolchevique- practicara una política amistosa hacia movimientos supuestamente comunistas</p>
Las dificultades para construir el Estado nacional en el Perú. Desde la independencia hasta la república aristocrática (1821-1900)
Authors: González Osmar 
Published: January 2016

<p>En el presente artículo, el autor realiza una lectura que indaga en las condiciones que retrasaron la formación del Estado nacional peruano desde el tiempo de la posindependencia (1821-1824) hasta el inicio de la república oligárquica en 1894 -1895. Al mismo tiempo, se analiza críticamente la literatura que ha tratado dicho periodo, discutiendo brevemente algunas afirmaciones muy comunes en las ciencias sociales respecto al Estado oligárquico peruano.</p>
El Plan de Casa Mata y el federalismo en Nuevo León, 1823
Authors: Jáuregui Luis 
Published: January 2016

<p>El Plan de Casa Mata replaneaba la unión de las provincias del país con el centro. El artículo revisa las características particulares de las Provincias Internas de Oriente, dadas en parte por su lejanía y en parte por el régi­men de excepción con el que habían sido creadas. Muestra la rivalidad enrre Saltillo y Monterrey por obtener la capital de la pro­vincia, misma que dio lugar a su separación posterior y a las diferencias entre ellas y en­tre las ideologías de los hombres que las dirigían o manipulaban: fray Servando Teresa de Mier, Miguel Ramos Arizpe y Felipe de<br />la Garza.</p>
Historias de gringos y campesinos: una revisita a la ocupación estadunidense de la República Dominicana, 1916-1924
Authors: San Miguel Pedro L. 
Published: January 2016

<p>Una de las repercusiones de la ocupación militar de la República Dominicana por los Estados Unidos entre 1916 y 1924 fue la activación de diversos movimientos campesinos. Cada uno de estos movimientos contó con su propia dinámica y operó en un escenario particular. Este artículo realiza una reinterpretación de ese periodo crucial de la historia dominicana desde la perspectiva de esos movimientos sociales. Presta particular importancia al <em>olivorismo</em>, un movimiento milenarista que surgió cerca de la frontera con Haití, y al <em>gavillerismo</em>, una guerrilla rural que tuvo como eje la región oriental de la República Dominicana. Se arguye que la derrota de estos movimientos constituyó un aspecto fundamental de la “domesticación” del campesinado y de su subordinación al Estado.</p><p> </p><p> </p>
Jean François. De la revolución haitiana a su exilio en España
Authors: Victoria Ojeda Jorge 
Published: January 2016

<p>El artículo se ocupa de Jean François, uno de los principales caudillos esclavos de la revolución haitiana quien jugó un papel importante en la contienda armada desarrollada en la isla de La Española. Primero se sublevó en unión con otros esclavos, buscando la libertad y proclamando la monarquía francesa; posteriormente España lo ganó para su causa, dejándose Jean François llevar por intereses personales y olvidando sus antiguos ideales de libertad general. Terminó sus días en un exilio forzado, sin que la corona hispana cumpliera las promesas ofrecidas.</p><p> </p><p> </p>
De amor y conveniencia : la familia Carvajal y las redes de parentesco : Campeche, 1841-1853
Authors: Gantús Fausta 
Published: January 2016

<p>Para lograr la consolidación en el usufructo del control regional, los miembros de la sociedad campechana del siglo XIX apostaron por la formación de alianzas familiares y redes de parentesco y clientelares, implementadas sobre la base de la unión matrimonial; como ejemplo destacado presentamos un estudio de caso sobre la familia Carvajal que ilustra la construcción del espacio de poder.</p><p> </p>