bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sala polivalente del Liceo Francés de Valencia
Authors: - Orts - Trullenque arquitectos 
Published: January 2018

In a built environment with a strong formal character (the charismatic “tambours” of the Lycée Français of Valence) the project takes on the cylindrical shape from the current buildings in order to fall within in place, politely, as a tree in the woods. After solving some sensitive project situations, as the access of service vehicles, using the plot topography, the proposal converts the site insertion strategy into an architectural strategy. This approach results in great working, energetically and economically, for the new building. The rest consists of planting trees, lots of them. The new multi-purpose room will be a remarkable space for the future LFV. It will be his picture towards the exterior, but it also will remain in the memory of people who lived special moments in it.
En un entorno construido con un fuerte carácter formal (los carismáticos “tambours” del Liceo Francés de Valencia y sus fluidos y divertidos espacios intersticiales), el proyecto asume la forma cilíndrica de sus edificios vecinos para insertarse, con educación, en el sitio, en un juego de iguales y diferentes, como lo haría un árbol en un bosque. A partir de esta decisión y después de dejar resueltos, gracias a la topografía de la parcela, algunos aspectos delicados del proyecto relativos a los accesos rodados de servicio, la propuesta amplía esta estrategia de inserción hasta convertirla en una estrategia arquitectónica en sí misma que se traduce en excelentes resultados energéticos y presupuestarios gracias al factor de forma del nuevo edificio.El resto consiste en poner árboles, muchos árboles. Espacio y carácter: la nueva Sala polivalente será un espacio singular del futuro LFV, será su escaparate hacia el exterior, pero también será ese espacio que permanecerá en la memoria de todos sus usuarios por lo especial de los momentos que hayan vivido en él.
Climate Impacts in Europe Under +1.5°C Global Warming
Authors: Jacob Daniela , Kotova Lola , Teichmann Claas , Sobolowski Stefan P. , Vautard Robert , Donnelly Chantal , Koutroulis Aristeidis G. , Grillakis Manolis G. , Tsanis Ioannis K. , Damm Andrea , Sakalli Abdulla , van Vliet Michelle T. H. 
Published: January 2018

AbstractThe Paris Agreement of the United Nations Framework Convention on Climate Change aims not only at avoiding +2°C warming (and even limit the temperature increase further to +1.5°C), but also sets long‐term goals to guide mitigation. Therefore, the best available science is required to inform policymakers on the importance of and the adaptation needs in a +1.5°C warmer world. Seven research institutes from Europe and Turkey integrated their competencies to provide a cross‐sectoral assessment of the potential impacts at a pan‐European scale. The initial findings of this initiative are presented and key messages communicated. The approach is to select periods based on global warming thresholds rather than the more typical approach of selecting time periods (e.g., end of century). The results indicate that the world is likely to pass the +1.5°C threshold in the coming decades. Cross‐sectoral dimensions are taken into account to show the impacts of global warming that occur in parallel in more than one sector. Also, impacts differ across sectors and regions. Alongside the negative impacts for certain sectors and regions, some positive impacts are projected. Summer tourism in parts of Western Europe may be favored by climate change; electricity demand decreases outweigh increases over most of Europe and catchment yields in hydropower regions will increase. However, such positive findings should be interpreted carefully as we do not take into account exogenous factors that can and will influence Europe such as migration patterns, food production, and economic and political instability.
Alternative Palladium‐Catalyzed Vinylic C−H Difluoroalkylation of Ketene Dithioacetals Using Bromodifluoroacetate Derivatives
Authors: Tian Shuangquan , Song Xiaoning , Zhu Dongsheng , Wang Mang 
Published: January 2018

AbstractA palladium‐catalyzed cross‐coupling of α‐oxo ketene dithioacetals and bromodifluoroacetate derivatives has been developed for the synthesis of a class of CF2‐containing tetra‐substituted olefins, which has potential to extend to drug design and material application. The process is proposed to involve two single electron transfer processes accompanied by an alternative loop from palladium(0) to palladium(I), likely due to unique structural properties of ketene dithioacetals with β,β‐dialkylthiol substituents on the olefin double bond.magnified image
Interpenetrating Triphase Cobalt‐Based Nanocomposites as Efficient Bifunctional Oxygen Electrocatalysts for Long‐Lasting Rechargeable Zn–Air Batteries
Authors: Jiang Yi , Deng Ya‐Ping , Fu Jing , Lee Dong Un , Liang Ruilin , Cano Zachary Paul , Liu Yangshuai , Bai Zhengyu , Hwang Sooyeon , Yang Lin , Su Dong , Chu Weiguo , Chen Zhongwei 
Published: January 2018

AbstractRational construction of atomic‐scale interfaces in multiphase nanocomposites is an intriguing and challenging approach to developing advanced catalysts for both oxygen reduction (ORR) and evolution reactions (OER). Herein, a hybrid of interpenetrating metallic Co and spinel Co3O4 “Janus” nanoparticles stitched in porous graphitized shells (Co/Co3O4@PGS) is synthesized via ionic exchange and redox between Co2+ and 2D metal–organic‐framework nanosheets. This strategy is proven to effectively establish highways for the transfer of electrons and reactants within the hybrid through interfacial engineering. Specifically, the phase interpenetration of mixed Co species and encapsulating porous graphitized shells provides an optimal charge/mass transport environment. Furthermore, the defect‐rich interfaces act as atomic‐traps to achieve exceptional adsorption capability for oxygen reactants. Finally, robust coupling between Co and N through intimate covalent bonds prohibits the detachment of nanoparticles. As a result, Co/Co3O4@PGS outperforms state‐of‐the‐art noble‐metal catalysts with a positive half‐wave potential of 0.89 V for ORR and a low potential of 1.58 V at 10 mA cm−2 for OER. In a practical demonstration, ultrastable cyclability with a record lifetime of over 800 h at 10 mA cm−2 is achieved by Zn–air batteries with Co/Co3O4@PGS within the rechargeable air electrode.
Computational Insights into the Reaction Mechanisms of Nickel‐Catalyzed Hydrofunctionalizations and Nickel‐Dependent Enzymes
Authors: Zhang Tonghuan , Zhang Xiaoyong , Chung Lung Wa 
Published: January 2018

AbstractFor several decades, transition‐metal catalysis has been a popular method for many functional group transformations in organic chemistry. Recent developments in sustainability and applications of earth‐abundant metals have resulted in a synthetic renaissance and have attracted considerable interest in less toxic and inexpensive first‐row transition‐metal catalysts such as nickel. Herein, we highlight some recent computational insights into the reaction mechanisms of Ni‐catalyzed hydrofunctionalizations (i.e., hydrogenation, hydrovinylation, hydroacylation, hydroheteroarylation, hydrosilylation, and hydroalkoxylation) and Ni‐dependent enzymes (i.e., lactate racemase, methyl‐CoM reductase, and [NiFe]‐hydrogenase). These computational studies provide insights into these reaction mechanisms and thus assist in the development and design of sustainable catalysts.
Copper‐Catalyzed Direct C−H Bond Arylation of Benzoxazoles with Anilines
Authors: Feng Pengju , Ma Guojian , Zhang Tianyu , Wang Changwei 
Published: January 2018

AbstractAn efficient and easily managed protocol was developed for the synthesis of 2‐aryl‐substituted benzoxazoles by using a copper‐catalyzed C−H arylation reaction between benzoxazole derivatives and in situ generated aryl diazonium salts. Under the optimized conditions, a wide variety of products were selectively obtained in moderate to good yields. Diphenylamine and 2,3′‐bipyridine were also obtained under the same reaction conditions by employing aniline and pyridin‐3‐amine, respectively, as the sole starting material.
Facile Syntheses, Characterization, and Physical Properties of Sulfur‐Decorated Pyran‐Annulated Perylene Diimides
Authors: Wang Ran , Li Gang , Zhou Yecheng , Hao Pin , Shang Qiaoyan , Wang Shuaihua , Zhang Yu , Li Dandan , Yang Shufan , Zhang Qichun , Shi Zhiqiang , Tang Bo 
Published: January 2018

AbstractThree sulfur‐containing pyran‐annulated perylene diimides (PDIs) were synthesized from commercially available PDIs through a nucleophilic substitution/cyclization reaction sequence. The as‐synthesized compounds were fully characterized by 1H and 13C NMR, and FT‐IR spectroscopy, as well as HRMS and TGA. The as‐prepared PDI derivatives exhibited significantly narrow HOMO–LUMO band gaps and high photochemical and thermal stability. Moreover, these materials exhibited quite different absorptions and emissions in dichloromethane, which were in agreement with the DFT‐calculated results.
Palladium‐Catalyzed Regioselective Aromatic Extension of Internal Alkynes through a Norbornene‐Controlled Reaction Sequence
Authors: Zhao Qingyang , Fu Wai Chung , Kwong Fuk Yee 
Published: January 2018

AbstractA regioselective aromatic π‐extension reaction of internal alkynes is reported. The proposed method employs three easily available components, namely aryl halides, 2‐haloarylcarboxylic acids, and disubstituted acetylenes. The transformation is driven by a controlled reaction sequence of C−H activation, decarboxylation, and annulation to give poly(hetero)aromatic compounds in a site‐selective fashion. Unlike in previously reported palladium‐catalyzed three‐component annulations, alkyne carbopalladation is the last step of this tandem reaction.
The Meaning of Intraoperative Errors: Perioperative Nurse Perspectives
Authors: Chard Robin , Tovin Melissa 
Published: January 2018

AbstractMedical errors involve different health care professionals, are multifaceted, and can occur at the individual practitioner or system level. The conditions for errors vary in the health care environment; some practice areas may be more vulnerable to errors than others. Limited research exists that explores perioperative nursing errors. The purpose of this study was to describe and interpret the experiences of perioperative nurses related to intraoperative errors. We used the hermeneutic phenomenological method. Ten perioperative RNs participated in focus group interviews that we audio‐recorded and transcribed. We analyzed data using thematic analysis, and three themes emerged that represent the essence of the experience of nurses involved in intraoperative errors: environment, being human, and moving forward. The findings support efforts to improve quality care and foster a culture of safety in the OR through strategies such as perioperative staff training, interprofessional team building, and controlling environmental factors that are distracting.
Effectiveness of modified hyper‐CVAD chemotherapy regimen in the treatment of adult acute lymphoblastic leukemia: a retrospective experience
Authors: Jalaeikhoo Hasan , Rajaeinejad Mohsen , Keyhani Manoutchehr , Zokaasadi Mohammad , Dehghani Firoozabadi Mohammad Mehdi 
Published: January 2018

AbstractSeveral chemotherapy regimens have been developed for the treatment of acute lymphoblastic leukemia (ALL), but relapse still presents the most common obstacles to attaining long‐term survival. The hyper‐CVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, and prednisolone)/HD MTX and Ara‐C (high‐dose methotrexate and cytarabine) chemotherapy regimen was first started in the MD Anderson Cancer Center as an intensive regimen for adult patients with ALL. The purpose of this study was to evaluate the effectiveness of a modified hyper‐CVAD protocol. We used hyper‐CVAD as consolidation/maintenance after remission induction with daunorubicin, vincristine, and prednisolone (and cyclophosphamide for T‐cell ALL only) rather than standard hyper‐CVAD in order to reduce treatment complications. This study was conducted as a retrospective review of medical records of ALL patients at 501 army hospital, Tehran, Iran, from 2005 to 2015. Three hundred and one patients underwent modified hyper‐CVAD chemotherapy regimen. Complete remission and overall survival (OS) rates were measured as primary endpoints. Two hundred and forty‐six (81.7%) reached complete remission (CR) during the first 6 months of treatment, and 55 patients (18.3%) did not reach CR. The 5‐year OS rate was 51.8% (95% CI (confidence interval): 45.1–57.8%). Modified hyper‐CVAD regimen is an efficient intensive chemotherapy regimen for consolidation/maintenance of adults with newly diagnosed ALL and has an acceptable 5‐year overall that is comparable to standard hyper‐CVAD regimen.
Pyridone Luciferins and Mutant Luciferases for Bioluminescence Imaging
Authors: Zhang Brendan S. , Jones Krysten A. , McCutcheon David C. , Prescher Jennifer A. 
Published: January 2018

AbstractNew applications for bioluminescence imaging require an expanded set of luciferase enzymes and luciferin substrates. Here, we report two novel luciferins for use in vitro and in cells. These molecules comprise regioisomeric pyridone cores that can be accessed from a common synthetic route. The analogues exhibited unique emission spectra with firefly luciferase, although photon intensities remained weak. Enhanced light outputs were achieved by using mutant luciferase enzymes. One of the luciferin–luciferase pairs produced light on par with native probes in live cells. The pyridone analogues and complementary luciferases add to a growing set of designer probes for bioluminescence imaging.
Enhanced Efficiency of Electron–Hole Separation in Bi2O2CO3 for Photocatalysis via Acid Treatment
Authors: Huang Yongchao , Li Kunshan , Lin Ying , Tong Yexiang , Liu Hong 
Published: January 2018

AbstractWe herein prepared defective Bi2O2CO3 microspheres via a simple nitric acid treatment method. Upon generation from Bi2O2CO3, electrons and holes were superbly separated with the existence of defects. Combined with the advantages of multiple scattering and reflection, a large surface area and increased range of visible‐light absorption, the defective Bi2O2CO3 dispalyed a high efficiency for the photodegradation of HCHO gases and methyl orange. The defective Bi2O2CO3 also possessed a superior stability, which is important for practical applications. This work opens up new opportunities for the design and fabrication of high‐activity Bi‐based photocatalysts for environmental protection.
Advanced Continuous Flow Platform for On‐Demand Pharmaceutical Manufacturing
Authors: Zhang Ping , Weeranoppanant Nopphon , Thomas Dale A. , Tahara Kohei , Stelzer Torsten , Russell Mary Grace , O'Mahony Marcus , Myerson Allan S. , Lin Hongkun , Kelly Liam P. , Jensen Klavs F. , Jamison Timothy F. , Dai Chunhui , Cui Yuqing , Briggs Naomi , Beingessner Rachel L. , Adamo Andrea 
Published: January 2018

AbstractAs a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time‐scale, we previously reported a refrigerator‐sized continuous flow system for the on‐demand production of essential medicines. Building on this technology, herein we report a second‐generation, reconfigurable and 25 % smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L)×0.5 (D)×1.3 m (H)] stand‐alone units for synthesis and purification/formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards.
Diffusion, Ion Pairing and Aggregation in 1‐Ethyl‐3‐Methylimidazolium‐Based Ionic Liquids Studied by 1H and 19F PFG NMR: Effect of Temperature, Anion and Glucose Dissolution
Authors: D'Agostino Carmine , Mantle Mick D. , Mullan Claire L. , Hardacre Christopher , Gladden Lynn F. 
Published: January 2018

AbstractIn this work, using 1H and 19F PFG NMR, we probe the effect of temperature, ion size/type and glucose dissolution on the rate of transport in 1‐ethyl‐3‐methylimidazolium ([EMIM]+)‐based ionic liquids by measuring self‐diffusion coefficients. Using such data, we are able to establish the degree of ion pairing and quantify the extent of ionic aggregation during diffusion. For the neat 1‐ethyl‐3‐methylimidazolium acetate ([EMIM][OAc]) a strong degree of ion pairing is observed. The substitution of the [OAc]− anion with the bis{(trifluoromethyl)sulfonyl}imide ([TFSI]−) anion reduces the pairing between the ions, which is attributed to a lower electric charge density on the [TFSI]− anion, hence a weaker electric interaction with the [EMIM]+ cation. The effect of glucose, important for applications of ionic liquids as extracting media, on the strongly paired [EMIM][OAc] sample was also investigated and it is observed that the carbohydrate decreases the degree of ion pairing, which is attributed to the ability of glucose to disrupt inter‐ionic interactions by forming hydrogen bonding, particularly with the [OAc]− anion. Calculations of aggregation number from diffusion data show that the [OAc]− anion diffuses as a part of larger aggregates compared to the [EMIM]+ cation. The results and analysis presented here show the usefulness of PFG NMR in studies of ionic liquids, giving new insights into ion pairing and aggregation and the factors affecting these parameters.
Development of an electrophoretic method based on nanostructured materials for HbA1c determination
Authors: Hamer Mariana , Bassi Narella , Agata Grela Denise 
Published: January 2018

AbstractGlycosylated hemoglobin (HbA1c) detection is performed routinely in hospitals as it is the most widespread confirmatory diagnosis of diabetes mellitus. Here we present a novel CE method for measuring HbA1c by introducing silica nanoparticles (NPs) modified with a boronic acid derivative (sugar loadings of 51 ± 2 μg/mg) as pseudo‐stationary phase. Before the sample injection, SiO2NP─B(OH)2 were introduced via pressure. Electrophoretic separation was explored through variation of the buffer pH and separation voltage, being the best separation, resolution and shorter separation time achieved with a 25 mM phosphate buffer pH 6.5. The calibration curve obtained was expressed as Area = 182.05%−1 × HbA1c − 377.02; R2 = 0.9826, using a UV/VIS absorbance detector at 415 nm (diode array). No interferences were observed from carbamylated or acetylated hemoglobin and the method shows a noteworthy stability. A paired t‐test was applied to compare the developed CE method with a commercial HbA1c test and no significant variations have been observed at a 90% significance level.
miR147b:Anovel key regulator of interleukin 1 beta‐mediated inflammation in human astrocytes
Authors: van Scheppingen Jackelien , Mills James D. , Zimmer Till S. , Broekaart Diede W.M. , Iori Valentina , Bongaarts Anika , Anink Jasper J. , Iyer Anand M. , Korotkov Anatoly , Jansen Floor E. , van Hecke Wim , Spliet Wim G. , van Rijen Peter C. , Baayen Johannes C. , Vezzani Annamaria , van Vliet Erwin A. , Aronica Eleonora 
Published: January 2018

AbstractAstrocytes are important mediators of inflammatory processes in the brain and seem to play an important role in several neurological disorders, including epilepsy. Recent studies show that astrocytes produce several microRNAs, which may function as crucial regulators of inflammatory pathways and could be used as therapeutic target. We aim to study which miRNAs are produced by astrocytes during IL‐1β mediated inflammatory conditions in vitro, as well as their functional role and to validate these findings in human epileptogenic brain tissue. Sequencing was used to assess miRNA and mRNA expression in IL‐1β‐stimulated human fetal astrocyte cultures. miRNAs were overexpressed in cell cultures using miRNA mimics. Expression of miRNAs in resected brain tissue from patients with tuberous sclerosis complex or temporal lobe epilepsy with hippocampal sclerosis was examined using in situ hybridization. Two differentially expressed miRNAs were found: miR146a and miR147b, which were associated with increased expression of genes related to the immune/inflammatory response. As previously reported for miR146a, overexpression of miR147b reduced the expression of the pro‐inflammatory mediators IL‐6 and COX‐2 after IL‐1β stimulation in both astrocyte and tuberous sclerosis complex cell cultures. miR146a and miR147b overexpression decreased proliferation of astrocytes and promoted neuronal differentiation of human neural stem cells. Similarly to previous evidence for miR146a, miR147b was increased expressed in astrocytes in epileptogenic brain. Due to their anti‐inflammatory effects, ability to restore aberrant astrocytic proliferation and promote neuronal differentiation, miR146a and miR147b deserve further investigation as potential therapeutic targets in neurological disorders associated with inflammation, such as epilepsy.
Application of Sal classification to parotid gland fine‐needle aspiration cytology: 10‐year retrospective analysis of 312 patients
Authors: Kilavuz Ahmet Erdem , Songu Murat , İmre Abdulkadir , Arslanoğlu Secil , Özkul Yilmaz , Pinar Ercan , Ateş Düzgün 
Published: January 2018

AbstractBackgroundThe accuracy of fine‐needle aspiration biopsy (FNAB) is controversial in parotid tumors. We aimed to compare FNAB results with the final histopathological diagnosis and to apply the “Sal classification” to our data and discuss its results and its place in parotid gland cytology.MethodsThe FNAB cytological findings and final histological diagnosis were assessed retrospectively in 2 different scenarios based on the distribution of nondefinitive cytology, and we applied the Sal classification and determined malignancy rate, sensitivity, and specificity for each category.ResultsIn 2 different scenarios FNAB sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were found to be 81%, 87%, 54.7%, and 96.1%; and 65.3%, 100%, 100%, and 96.1%, respectively. The malignancy rates and sensitivity and specificity were also calculated and discussed for each Sal category.ConclusionWe believe that the Sal classification has a great potential to be a useful tool in classification of parotid gland cytology.
Dividend policy and bank opacity
Authors: Tran Dung Viet , Ashraf Badar Nadeem 
Published: January 2018

AbstractDoes dividend policy increase or decrease bank opaqueness? Under the Dividend–Transparency Channel, paying dividends involves banks having greater discipline from the markets due to external financing and reduces private benefits of control, leading to lower earnings management concerns. Under the Dividend–Opacity Channel, due to a hesitancy to change dividend policy, banks have high vocations to engage earnings management to circumvent payout policy restrictions in debt covenants or to keep their dividend target unchanged. Employing a large sample of 2,483 U.S. bank holding companies from 2001:Q1–2013:Q4, the study documents the double‐edged sword of dividends on the discretionary behaviours of banks. Paying dividends makes banks less opaque to compare with nonpayers, which is consistent with the Dividend–Transparency Channel, however among dividend paying banks, excessive dividends involve banks to manage more their numbers, which is consistent with the Dividend–Opacity Channel. The findings are robust under different specifications. The results are of important interest to bank regulators.