bluuebunny/crossref_metadata_2025_split huggingface dataset:
Field Theory and Interdisciplinarity: History and Sociology in Germany and France during the Twentieth Century
Authors: Steinmetz George 
Published: April 2017

AbstractThis article develops a theory of interdisciplinarity and examines relations between historians and sociologists in Germany and France over the course of the twentieth century, focusing in on several key moments of interdisciplinary activity. Interdisciplinary engagements are motivated by scholarly problems, field-specific interests and battles, and pressures and inducements coming from states, businesses, and scientific institutions. Analysis of the most productive moments of cross-disciplinary interaction suggests that they occur when disciplines are equal in power and when scholars are motivated by scholarly problems and disciplinary conflicts to move beyond their disciplines. More generative forms of interdisciplinarity are dialogic and processual, characterized by a fusion of perspectives; less productive forms are externally induced, involve asymmetrical partners, and are organized around division of disciplinary labor rather than an interpenetration of perspectives. The most productive interdisciplinary conjunctures result from serendipitous resonances and contingent synchronicities between subfields of semi-autonomous disciplines. It is thus impossible to produce the most fruitful forms of interdisciplinarity deliberately. The article examines three cases of symmetrical, processual interdisciplinarity involving sociology and history. Two of these cases were located in the French academic field, first between the wars, and then again after 1980. The other case of dialogic collaboration between historians and sociologists begins in Nazi Germany and continues after 1945 into the 1960s, leading to the formation of West GermanHistorische Sozialwissenschaft. Examples of unbalanced interdisciplinarity include German “History-Sociology” during the Weimar Republic, in which sociologists’ opening to history was not reciprocated by professional historians andHistorische Sozialwissenschaftafter 1970.
EFFECT OF EARLY SEXUAL DEBUT ON HIGH SCHOOL COMPLETION IN SOUTH AFRICA
Authors: Bengesai A. V. , Khan H. T. A. , Dube R. 
Published: April 2017

SummaryEarly sexual debut is of major concern because it is a correlate for health and economic shocks experienced in adulthood. In South Africa, this concern has provided impetus for research directed at the HIV and AIDS epidemic, teenage pregnancy and the effect of adolescent sexual behaviour on persistence in school. Of interest to the present study is high school completion, which is a well-established empirical barometer of adult socioeconomic opportunities. Using data from the five waves of the Cape Area Panel Study (CAPS), this paper examines the association between sexual behaviours initiated in pre- and early adolescence and high school completion rates. The CAPS study is a longitudinal survey that was designed to investigate young people’s (aged 14–22 years) educational attainment and sexual behaviours in Cape Town, South Africa. The sample was constituted from 3213 individuals who had initiated sex during their teenage years and the analysis was undertaken when the youngest cohort was aged 21, an age at which they should have completed high school if they were on time. Logistic regression models were fitted separately for males and females. Overall, the results reveal that early sexual debut is correlated with long-term negative educational outcomes. Individuals who experience early sexual debut are less likely to complete high school than their counterparts who make their sexual debut later on in life. This effect is worse for Africans, who also disproportionately have an earlier sexual debut than other race groups. Apart from race however, the findings also reinforce the effect of other demographic factors on high school completion, namely, place of residence and family socioeconomic status as measured by parental education and household income. Hence, early sexual debut adds another layer of inequality and worsens the plight of Africans, females, those living in rural areas and those who come from low-income families.
Coolie Therapeutics: Labor, Race, and Medical Science in Tropical Australia
Authors: Anderson Warwick 
Published: April 2017

AbstractThis essay considers the biomedical framing of labor in tropical Australia from the late-nineteenth century until the early twenty-first century. This entails critical inquiry into racialized estimates of labor capacity or fitness, as well as skeptical examination of medical assumptions of risk and danger. Racial theories and medical conjectures have constituted flexible analytic toolkits that might adjust, adapt, and justify a variety of exploitative labor practices in Australia’s tropical north. Debates about coolie or indentured labor were never simply economic calculations: They also concerned notions of races and their proper places, and expressed particular moral sensibilities and medical fears. Thus labor history becomes entangled with histories of racial formation and of science and medicine
Healthcare innovation and patent law’s ‘pharmaceutical privilege’: is there a pharmaceutical privilege? And if so, should we remove it?
Authors: Dutfield Graham 
Published: April 2017

AbstractThis article reviews current trends in patent claims regarding personalised, stratified and precision medicine. These trends are not particularly well understood by policymakers, even less by the public, and are quite recent. Consequently, their implications for the public interest have hardly been thought out. Some see personalised and other secondary drug patent claims as promoting better targeted treatment. Others are inclined to see them as \manifestations of ‘evergreening’ whereby companies are, in some cases quite cynically, trying to extend market monopolies in old products or creating new monopolies based on supposedly improved versions of such earlier drugs. The article claims that the relaxation of ‘novelty’ is a privilege unavailable to inventions in other fields and that on balance the patent systemdoesprivilege this industry and that no adequate case has yet been made thus far to prove the public benefits overall.
Making the Most of Capital in the Twenty-First Century
Authors: Lindert Peter H. 
Published: April 2017

Abstracts
Thomas Piketty’s monumental Capital in the Twenty-First Century has transported us to a higher understanding of the historical evolution of inequality. This essay attempts to inventory the different avenues of research, more or less promising, that scholars might usefully pursue when building on his work. The most important path to follow is the history of inequalities in income that Piketty and his team have flagged up so well, supported by the book’s history of the great shocks of the twentieth century and the political responses that they elicited. Less promising is the book’s emphasis on wealth, capital, and the rate of return. The best predictions of future inequality can be achieved by merging Piketty and his team’s history of those who hold the top 10 percent of income with works dedicated to the history of inequality within the lower 90 percent. It is also necessary to integrate other scholarship that has demonstrated that the sort of democratic system Piketty calls for would have positive effects on growth.
History in the Classroom An Undisciplined Subject
Authors: De Cock Laurence 
Published: April 2017

Abstract
This paper argues that a discipline taught in schools is more than a mere copy of scientific knowledge. It investigates the relationship between scholarly and pedagogic knowledge from the end of the nineteenth century, when the teaching of history was tasked with participating in the construction of a shared national culture. In fact, it is only by mobilizing tools from the social sciences that the complexity of history teaching can be understood. The repeated accusations directed at the teaching of history in schools therefore reflect a trite and hackneyed understanding of its nature and mission.
Making the History of Early Modern Science: Reflections on a Discipline in the Age of Globalization
Authors: Romano Antonella 
Published: April 2017

Abstract
What kind of history is the history of science? To what extent does the academic research labeled as such delineate a homogeneous field? What are the current challenges that it faces? The recent translation of Simon Schaffer’s works into French, along with the publication of his 2014 Marc Bloch Lecture in the Annales, provides the framework for this article’s historiographical reflection on the profound changes that have taken place within the discipline over the last thirty years, particularly within a French context. The analysis is twofold. First, it aims to trace how new approaches to the sociology and anthropology of science have reconfigured the boundaries of the discipline. Second, it considers the effect of the abandonment of one of its major historiographical paradigms by most of the scholars currently working on early modern science: the scientific revolution as the rise of scientific modernity, underpinned by a Eurocentric vision of the production of knowledge. Although most research on the early modern period now strives to distance itself from this narrative, it must also face new challenges and questions—in particular the role of science in the processes of globalization and the multiplicity of sites and social configurations that participate in this change of scale. These challenges point towards new methods and styles in the history of science and, more broadly, the social sciences.
Ceremonies of Measurement: Rethinking the World History of Science
Authors: Schaffer Simon 
Published: April 2017

Abstract
The practices of measurement have long been taken as authoritative technologies that travel unusually well and easily across cultural boundaries, and as a sign and cause of the apparent dominance of Western modes of science. Attention to the rituals of measurement and to the emergence of the forms of knowledge that accompanied measurement, notably the sciences of metrology, helps challenge these assumptions. Stories of the silent trade, often located in western Africa, and of the ritual origins of measurement, developed within anthropology and conjectural history, can be used to explore how measurement practices traveled and changed. In particular, the work of Marc Bloch as the preeminent historian of ceremony and power can help illuminate the relation between the historical geography of metrology and the scope of the sciences. His brilliant analysis of the royal ritual of “cramp rings” and its fate provides an important example and precedent for comparably ceremonial and culturally significant episodes in the long history of the science of measurement.
Exercise contagion in a global social network
Authors: Aral Sinan , Nicolaides Christos 
Published: April 2017

AbstractWe leveraged exogenous variation in weather patterns across geographies to identify social contagion in exercise behaviours across a global social network. We estimated these contagion effects by combining daily global weather data, which creates exogenous variation in running among friends, with data on the network ties and daily exercise patterns of ∼1.1M individuals who ran over 350M km in a global social network over 5 years. Here we show that exercise is socially contagious and that its contagiousness varies with the relative activity of and gender relationships between friends. Less active runners influence more active runners, but not the reverse. Both men and women influence men, while only women influence other women. While the Embeddedness and Structural Diversity theories of social contagion explain the influence effects we observe, the Complex Contagion theory does not. These results suggest interventions that account for social contagion will spread behaviour change more effectively.
Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms
Authors: Rodriguez Herrero Esteban , Boon Nico , Pauwels Martine , Bernaerts Kristel , Slomka Vera , Quirynen Marc , Teughels Wim 
Published: April 2017

AbstractThe oral use of antimicrobial agents embedded in toothpastes and mouth rinses results in an oral microbial massacre with high amounts of dead bacteria in close proximity to few surviving bacteria. It was hypothesized that this provides the surviving pathogenic bacteria a large amount of dead microbial biomass as a nutritional source for growth (necrotrophy). This study demonstrated the necrotrophic growth of periodontal pathogens in the presence of different dead oral species. In addition, the presence of dead bacteria resulted in an outgrowth of several periodontal pathogens in complex multi-species biofilms. Additionally, upon contact with dead oral bacteria, virulence genes of P. intermedia and P. gingivalis were up-regulated (necrovirulence). This resulted in a more pronounced epithelial cytotoxicity (necrotoxicity). These findings indicate that presence of dead bacteria induce necrotrophy, necrovirulence and necrotoxicity in several oral pathogens.
Quality and freshness of human bone marrow-derived mesenchymal stem cells decrease over time after trypsinization and storage in phosphate-buffered saline
Authors: Shin Tae Hwan , Lee Seungah , Choi Ki Ryung , Lee Da Yeon , Kim Yongman , Paik Man Jeong , Seo Chan , Kang Seok , Jin Moon Suk , Yoo Tae Hyeon , Kang Seong Ho , Lee Gwang 
Published: April 2017

AbstractHuman bone marrow-derived mesenchymal stem cells (hBM-MSCs) have been studied for their therapeutic potential. However, evaluating the quality of hBM-MSCs before transplantation remains a challenge. We addressed this issue in the present study by investigating deformation, the expression of genes related to reactive oxygen species (ROS) generation, changes in amino acid profiles, and membrane fluidity in hBM-MSCs. Deformability and cell size were decreased after storage for 6 and 12 h, respectively, in phosphate-buffered saline. Intracellular ROS levels also increased over time, which was associated with altered expression of genes related to ROS generation and amino acid metabolism. Membrane fluidity measurements revealed higher Laurdan generalized polarization values at 6 and 12 h; however, this effect was reversed by N-acetyl-l-cysteine-treatment. These findings indicate that the quality and freshness of hBM-MSCs is lost over time after dissociation from the culture dish for transplantation, highlighting the importance of using freshly trypsinized cells in clinical applications.
Light- and circadian-controlled genes respond to a broad light spectrum in Puffer Fish-derived Fugu eye cells
Authors: Okano Keiko , Ozawa Shoichi , Sato Hayao , Kodachi Sawa , Ito Masaharu , Miyadai Toshiaki , Takemura Akihiro , Okano Toshiyuki 
Published: April 2017

AbstractSome cell lines retain intrinsic phototransduction pathways to control the expression of light-regulated genes such as the circadian clock gene. Here we investigated the photosensitivity of a Fugu eye, a cell line established from the eye ofTakifugu rubripes, to examine whether such a photosensitive nature is present. Microarray analysis identified 15 genes that showed blue light-dependent change at the transcript level. We investigated temporal profiles of the light-induced genes, as well asCryandPer,under light-dark, constant light (LL), and constant dark (DD) conditions by quantitative RT-PCR. Transcript levels ofPer1aandPer3genes showed circadian rhythmic changes under both LL and DD conditions, while those ofCrygenes were controlled by light. All genes examined, including DNA-damage response genes and photolyase genes, were upregulated not only by blue light but also green and red light, implying the contribution of multiple photopigments. The present study is the first to identify a photosensitive clock cell line originating from a marine fish. These findings may help to characterize the molecular mechanisms underlying photic synchronization of the physiological states of fishes to not only daily light-dark cycles but also to various marine environmental cycles such as the lunar or semi-lunar cycle.
Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy
Authors: Mandai Shintaro , Furukawa Susumu , Kodaka Manami , Hata Yutaka , Mori Takayasu , Nomura Naohiro , Ando Fumiaki , Mori Yutaro , Takahashi Daiei , Yoshizaki Yuki , Kasagi Yuri , Arai Yohei , Sasaki Emi , Yoshida Sayaka , Furuichi Yasuro , Fujii Nobuharu L. , Sohara Eisei , Rai Tatemitsu , Uchida Shinichi 
Published: April 2017

AbstractMuscle wasting or sarcopenia contributes to morbidity and mortality in patients with cancer, renal failure, or heart failure, and in elderly individuals. Na+-K+-2Cl− cotransporter 1 (NKCC1) is highly expressed in mammalian skeletal muscle, where it contributes to the generation of membrane ion currents and potential. However, the physiologic function of NKCC1 in myogenesis is unclear. We investigated this issue using the NKCC1 inhibitors bumetanide and furosemide, which are commonly used loop diuretics. NKCC1 protein levels increased during C2C12 murine skeletal myoblast differentiation, similarly to those of the myogenic markers myogenin and myosin heavy chain (MHC). NKCC1 inhibitors markedly suppressed myoblast fusion into myotubes and the expression of myogenin and MHC. Furthermore, phosphorylated and total NKCC1 levels were elevated in mouse skeletal muscles after 6 weeks’ voluntary wheel running. Immunofluorescence analyses of myofiber cross-sections revealed more large myofibers after exercise, but this was impaired by daily intraperitoneal bumetanide injections (0.2 or 10 mg/kg/day). NKCC1 plays an essential role in myogenesis and exercise-induced skeletal muscle hypertrophy, and sarcopenia in patients with renal or heart failure may be attributable to treatment with loop diuretics.
Immune Tissue Print and Immune Capture-PCR for Diagnosis and Detection of Candidatus Liberibacter Asiaticus
Authors: Ding Fang , Paul Cristina , Brlansky Ron , Hartung John S. 
Published: April 2017

Abstract‘Candidatus Liberibacter asiaticus’ (CaLas), associated with citrus Huanglongbing (HLB), is a non culturable member of the α-proteobacteria. In this study serologically based methods for the detection of CaLas were developed. An anti-outer membrane protein A (OmpA) polyclonal antibody previously produced (in our laboratory) was highly effective for the detection of CaLas from citrus tissues in a simple tissue printing format. The antibody was also used to capture bacteria from periwinkle extracts. About 80% of all field samples analyzed tested positive with both immune tissue printing and qPCR; whereas 95% were positive with at least one of these two methods. When asymptomatic citrus tissues were tested, the tissue printing method gave a higher rate of detection (83%) than the qPCR method (64%). This is consistent with a lower concentration of CaLas DNA, but a higher proportion of viable cells, in the asymptomatic tissues. The immune tissue printing method also highlights the detail of the spatial distribution of ‘Ca. Liberibacter asiaticus’ in diseased citrus tissues. Both the immune capture PCR and immune tissue printing methods offer the advantages of low cost, high throughput, ease of scaling for multiple samples and simplicity over current PCR-based methods for the detection of ‘Ca. Liberibacter asiaticus’.
Transcriptome sequencing study implicates immune-related genes differentially expressed in schizophrenia: new data and a meta-analysis
Authors: Sanders A R , Drigalenko E I , Duan J , Moy W , Freda J , Göring H H H , Gejman P V ,   on behalf of MGS
Published: April 2017

AbstractWe undertook an RNA sequencing (RNAseq)-based transcriptomic profiling study on lymphoblastoid cell lines of a European ancestry sample of 529 schizophrenia cases and 660 controls, and found 1058 genes to be differentially expressed by affection status. These differentially expressed genes were enriched for involvement in immunity, especially the 697 genes with higher expression in cases. Comparing the current RNAseq transcriptomic profiling to our previous findings in an array-based study of 268 schizophrenia cases and 446 controls showed a highly significant positive correlation over all genes. Fifteen (18%) of the 84 genes with significant (false discovery rate<0.05) expression differences between cases and controls in the previous study and analyzed here again were differentially expressed by affection status here at a genome-wide significance level (Bonferroni P<0.05 adjusted for 8141 analyzed genes in total, or P<~6.1 × 10−6), all with the same direction of effect, thus providing corroborative evidence despite each sample of fully independent subjects being studied by different technological approaches. Meta-analysis of the RNAseq and array data sets (797 cases and 1106 controls) showed 169 additional genes (besides those found in the primary RNAseq-based analysis) to be differentially expressed, and provided further evidence of immune gene enrichment. In addition to strengthening our previous array-based gene expression differences in schizophrenia cases versus controls and providing transcriptomic support for some genes implicated by other approaches for schizophrenia, our study detected new genes differentially expressed in schizophrenia. We highlight RNAseq-based differential expression of various genes involved in neurodevelopment and/or neuronal function, and discuss caveats of the approach.
Vitamin B6–Responsive Epilepsy due to a Novel KCNQ2 Mutation
Authors: Lemke Johannes , Korinthenberg Rudolf , Jacobs Julia , Klotz Kerstin 
Published: April 2017

AbstractMutations in KCNQ2, encoding for subunits of potassium channels, are known to cause neonatal epileptic encephalopathy (NEE). Therapeutic options for these children are often limited. Recently, there are indications that some patients with KCNQ2 NEE show seizure response to vitamin B6 (VB6) therapy. We present a young infant with severe KCNQ2 encephalopathy resulting from a novel de novo mutation (c.1023G>C; p.(Gln341His)). In our patient, VB6 responsiveness could be demonstrated clearly by remarkable seizure-response to VB6 therapy and seizure exacerbation to discontinuation of VB6 therapy. The pathophysiology of VB6 response in potassium channel mutations is not understood. Some hypothetical mechanisms are currently in discussion. To identify the group of patients who benefits from VB6 therapy, further investigations are necessary.