bluuebunny/crossref_metadata_2025_split huggingface dataset:
Roles of Cognitive Status and Intelligibility in Everyday Communication in People with Parkinson’s Disease: A Systematic Review
Authors: Barnish Maxwell S. , Whibley Daniel , Horton Simon M.C. , Butterfint Zoe R. , Deane Katherine H.O. 
Published: August 2016

Background: Communication is fundamental to human interaction and the development and maintenance of human relationships and is frequently affected in Parkinson’s disease (PD). However, research and clinical practice have both tended to focus on impairment rather than participation aspects of communicative deficit in PD. In contrast, people with PD have reported that it is these participation aspects of communication that are of greatest concern to them rather than physical speech impairment. Objective: To systematically review the existing body of evidence regarding the association between cognitive status and/or intelligibility and everyday communication in PD. Methods: Five online databases were systematically searched in May 2015 (Medline Ovid, EMBASE, AMED, PsycINFO and CINAHL) and supplementary searches were also conducted. Two reviewers independently evaluated retrieved records for inclusion and then performed data extraction and quality assessment using standardised forms. Articles were eligible for inclusion if they were English-language original peer-reviewed research articles, book chapters or doctoral theses investigating the associations between at least one of cognitive status and level of intelligibility impairment and an everyday communication outcome in human participants with PD. Results: 4816 unique records were identified through database searches with 16 additional records identified through supplementary searches. 41 articles were suitable for full-text screening and 15 articles (12 studies) met the eligibility criteria. 10 studies assessed the role of cognitive status and 9 found that participants with greater cognitive impairment had greater everyday communication difficulties. 4 studies assessed the role of intelligibility and all found that participants with greater intelligibility impairment had greater everyday communication difficulties, although effects were often weak and not consistent. Conclusions: Both cognitive status and intelligibility may be associated with everyday communicative outcomes in PD. The contribution of intelligibility to everyday communication appears to be of small magnitude, suggesting that other factors beyond predominantly motor-driven impairment-level changes in intelligibility may play an important role in everyday communication difficulties in PD.
Assessment of Nonmotor Fluctuations Using a Diary in Advanced Parkinson’s disease
Authors: Ossig Christiana , Sippel Daniel , Fauser Mareike , Gandor Florin , Jost Wolfgang H. , Ebersbach Georg , Storch Alexander 
Published: August 2016

Background: Since previous studies aimed to study nonmotor symptom (NMS) fluctuations in direct conjunction with motor oscillations, there are no data available on the temporal context of NMS fluctuations and motor oscillations in advanced Parkinson’s disease (PD). Objective: To evaluate circadian patterns and temporal connections of NMS and motor fluctuations in PD. Methods: 15 controls, 17 non-fluctuating and 15 fluctuating PD patients completed two diaries by rating 4 key psychiatric (anxiety, depressive mood, inner restlessness, concentration/attention deficits), fatigue and 4 autonomic NMS (excessive sweating, sialorrhea, bladder urgency, dizziness) absent or present and motor function (Off, On with/without dyskinesia, and asleep) for every hour for 5 consecutive days. Results: NMS Off state hours (hours with NMS rated as present) were less frequent compared to motor Off state hours and NMS On-Off-switches were less prevalent compared to those of the motor state. Off time and number of On-Off-switches of psychiatric NMS were moderately correlated with motor Off time and number of motor On-Off switches on the individual patient level. Changes in NMS state occurred largely independent of changes in motor states with concordance rates of only 26–43% of all NMS changes for psychiatric and 7–17% for autonomic NMS. In controls and non-fluctuating PD patients, there were no NMS state switches in concordance to motor state switches. Conclusion: We provide first data on the temporal context of NMS fluctuations showing similar frequencies of psychiatric NMS Off, fatigue Off and motor Off times as well as their On-Off-fluctuations, but low concordance rates of NMS with motor On-Off-state switches. We found no evidence for NMS fluctuations in non-fluctuating PD patients. Our data implicate similar fluctuation patterns of mood NMS and motor function without close timing and/or different kinetics.
The Effects of Physical Activity in Parkinson’s Disease: A Review
Authors: Lauzé Martine , Daneault Jean-Francois , Duval Christian 
Published: August 2016

Background: Physical activity (PA) is increasingly advocated as an adjunct intervention for individuals with Parkinson’s disease (PD). However, the specific benefits of PA on the wide variety of impairments observed in patients with PD has yet to be clearly identified. Objective: Highlight health parameters that are most likely to improve as a result of PA interventions in patients with PD. Methods: We compiled results obtained from studies examining a PA intervention in patients with PD and who provided statistical analyses of their results. 868 outcome measures were extracted from 106 papers published from 1981 to 2015. The results were classified as having a statistically significant positive effect or no effect. Then, outcome measures were grouped into four main categories and further divided into sub-categories. Results: Our review shows that PA seems most effective in improving Physical capacities and Physical and cognitive functional capacities. On the other hand, PA seems less efficient at improving Clinical symptoms of PD and Psychosocial aspects of life, with only 50% or less of results reporting positive effects. The impact of PA on Cognitive functions and Depression also appears weaker, but few studies have examined these outcomes. Discussion: Our results indicate that PA interventions have a positive impact on physical capacities and functional capacities. However, the effect of PA on symptoms of the disease and psychosocial aspects of life are moderate and show more variability. This review also highlights the need for more research on the effects of PA on cognitive functions, depression as well as specific symptoms of PD.
Apathy in Mild Parkinson’s Disease: Neuropsychological and Neuroimaging Evidence
Authors: Alzahrani Hamad , Antonini Angelo , Venneri Annalena 
Published: August 2016

Background: Apathy is one of the most common neuropsychiatric symptoms in Parkinson’s disease (PD). Few studies have investigated the cognitive and neuroanatomical correlates of apathy in PD, and those which have done so have not controlled for the presence of other neuropsychiatric comorbidities. Objective: To explore the cognitive and neuroanatomical correlates of apathy in PD at a mild disease stage. Methods: Sixty-five PD patients and 24 healthy controls participated in this study. Patients underwent extensive neuropsychological screening, neuropsychiatric assessment using the Neuropsychiatric Inventory, structural MRI scanning, and neurological examination. Voxel-based independent t-test analyses were used to assess the differences in grey and white matter volumes between the sample groups with/without apathy/neuropsychiatric symptoms. Results: Patients with apathy had lower grey matter volume in several brain areas including the left insula, left inferior/middle/medial frontal gyrus, right anterior cingulate, and the left superior temporal gyrus. Significant impairments were found in tests assessing executive functions, and a trend-level significant difference was observed in long term memory tests in patients with apathy, when compared with patients without apathy. Conclusions: Apathy was associated with greater levels of atrophy in the frontal and temporal cortex, and anterior cingulate, as well as overall lower level of cognitive performance, particularly in executive function and memory skills. Apathy appears to be associated with cognitive impairments in PD, therefore, treatment of this symptom might mitigate its effects on cognitive performance in this clinical population.
Health and Social Service Access Among Family Caregivers of People with Parkinson’s Disease
Authors: Olsson Yvonne , Clarén Lena , Alvariza Anette , Årestedt Kristofer , Hagell Peter 
Published: August 2016

Background: Being a family caregiver for a person with Parkinson’s disease (PD) can negatively impact health and wellbeing, but it appears less clear to what extent caregivers’ health/social service needs are met. Objective: We explored the extent to which PD family caregivers experience sufficient access to health/social services, as compared to age-matched controls; and the associations between this and demographic and health-related variables. Methods: A cross-sectional survey of 66 PD family caregivers and 79 age-matched control subjects including the SF-36 health survey, the Nottingham Health Profile Sleep section (NHP-Sleep), and questions regarding contacts with various health/social related services and whether these were perceived as sufficient. Results: People reporting insufficient access ( n = 29) were more often PD family caregivers than controls (83% vs. 37%), did more often have a disease of their own (79% vs. 46%), and reported poorer health according to the SF-36 and the NHP-Sleep. Being a PD family caregiver (OR, 8.90), reporting more pain (OR, 1.02) and having an own disease (OR, 3.46) were independently associated with insufficient health/social service access. Conclusions: Our results imply that those in greatest need for health/social services (i.e., those with poorer health, an own disease, and who are PD family caregivers) are those whose health/social service needs are least met. Larger studies are needed for firmer conclusions and regarding how unmet health/social service needs impacts caregiver health and wellbeing. Health/social service providers should not only focus on patients but also consider their family members’ needs.
Impulse Control Disorders in Parkinson’s Disease are Associated with Alterations in Reward-Related Cortical Oscillations
Authors: Carriere Nicolas , Bourriez Jean-Louis , Delval Arnaud , Derambure Philippe , Defebvre Luc , Dujardin Kathy 
Published: August 2016

Background: Impulse control disorders (ICDs) in Parkinson’s disease (PD) are related to treatment with dopamine agonists, which is thought to deregulate the dopaminergic mesolimbic pathway and impair reward evaluation. EEG studies in healthy controls (HCs) have suggested that the increase in theta power observed after negative outcome is a marker of reward processing. Objective: To compare outcome-locked, event-related spectral perturbation in a gambling task in PD patients with and without ICDs and in HCs. Methods: Twelve PD patients with ICDs, 12 PD patients without ICDs and 14 HCs underwent EEG while performing a gambling task. The groups were compared in terms of (i) the peak EEG power in the theta (4–7 Hz), alpha (8–14 Hz) and beta (15–30 Hz) frequency bands between 200 and 500 ms after the outcome, and (ii) time-frequency plots at Fz, FCz and Cz. Results: Positive outcomes were associated with greater theta power than negative outcomes in patients without ICDs and in HCs, but not in patients with ICDs. Patients with ICDs and HCs displayed greater theta power following unexpectedly high outcomes. HCs displayed greater beta power following high amplitude than low amplitude outcomes, whereas patients with ICD showed the opposite pattern. Conclusions: In PD, ICDs are associated with (i) weaker modulation of frontocentral theta power by reward valence, (ii) greater frontocentral theta power following unexpected, high outcomes, and (iii) a reversal of the effect of risk on beta oscillations. These observations are consistent with an impairment in prediction error computation in the medial prefrontal cortex.
Effect of patient safety incident review and reflection in an extended morbidity and mortality meeting
Authors: Mehta Saurabh , Singh Harvinder Pal , Dias Joseph J. 
Published: August 2016

BACKGROUND: We modified the departmental mortality and morbidity (M&M) meetings to evaluate whether patient safety incident review as a part of this meeting was associated with reduced patient safety incidents. METHOD: A pilot programme of peer review of patient safety incidents (PSI) supported by education relevant to that event and follow-on action plan was introduced as a part of an extended morbidity and mortality meeting in a university hospital orthopaedic department. The pilot programme was conducted over six months (January 2012–June 2012). This programme involved junior and senior doctors including consultants although multidisciplinary groups were invited to attend. We investigated PSI rate/1000 hospital admissions for trauma and elective surgery, which were collected prospectively and independently between Jan 2011 to June 2013. We noted if the incident was caused by a medical or a nursing error and compared PSI rates. RESULTS: Rates of PSI (33/1000) were 7.8 times higher in trauma cases (80.2/1000) than in elective admissions (11.2/1000). There was 18% reduction in trauma and 27% reduction in planned elective admissions. The rate increased after the pilot programme finished but there was still a 7% reduction compared to the pre-pilot period. This study found a significant reduction in the PSI rate for medical error but no change in the rate of nursing error. CONCLUSION: This continuous reflection, education and action process, where safety events are reviewed as a part of the extended morbidity and mortality meeting, is associated with reduction of patient safety incidents. We recommend that PSI reflection should be introduced in Mortality and Morbidity meetings with mandated attendance of the entire multidisciplinary health care team.
Transcriptome sequencing and simple sequence repeat marker development for three Macaronesian endemic plant species
Authors: White Oliver W. , Doo Bethany , Carine Mark A. , Chapman Mark A. 
Published: August 2016

Premise of the study:Oceanic islands offer unparalleled opportunities to investigate evolutionary processes such as adaptation and speciation. However, few genomic resources are available for oceanic island endemics. In this study, we publish transcriptome sequences from three Macaronesian endemic plant species (Argyranthemum broussonetii [Asteraceae], Descurainia bourgaeana [Brassicaceae], and Echium wildpretii [Boraginaceae]) that are representative of lineages that have radiated in the region. In addition, the utility of transcriptome data for marker development is demonstrated.Methods and Results:Transcriptomes from the three plant species were sequenced, assembled, and annotated. Between 1972 and 2282 simple sequence repeats (SSRs) were identified for each taxon. Primers were designed and tested for 30 of the candidate SSRs identified in Argyranthemum, of which 12 amplified well across three species and eight were polymorphic.Conclusions:We demonstrate here that a single transcriptome sequence is sufficient to identify hundreds of polymorphic SSR markers. The SSRs are applicable to a wide range of questions relating to the evolution of island lineages.
CHARGED DUST GRAIN DYNAMICS SUBJECT TO SOLAR WIND, POYNTING–ROBERTSON DRAG, AND THE INTERPLANETARY MAGNETIC FIELD
Authors: Lhotka Christoph , Bourdin Philippe , Narita Yasuhito 
Published: August 2016

ABSTRACT
We investigate the combined effect of solar wind, Poynting–Robertson drag, and the frozen-in interplanetary magnetic field on the motion of charged dust grains in our solar system. For this reason, we derive a secular theory of motion by the means of an averaging method and validate it with numerical simulations of the unaveraged equations of motions. The theory predicts that the secular motion of charged particles is mainly affected by the z-component of the solar magnetic axis, or the normal component of the interplanetary magnetic field. The normal component of the interplanetary magnetic field leads to an increase or decrease of semimajor axis depending on its functional form and sign of charge of the dust grain. It is generally accepted that the combined effects of solar wind and photon absorption and re-emmision (Poynting–Robertson drag) lead to a decrease in semimajor axis on secular timescales. On the contrary, we demonstrate that the interplanetary magnetic field may counteract these drag forces under certain circumstances. We derive a simple relation between the parameters of the magnetic field, the physical properties of the dust grain, as well as the shape and orientation of the orbital ellipse of the particle, which is a necessary conditions for the stabilization in semimajor axis.
COMPARISON OF MAGNETIC PROPERTIES IN A MAGNETIC CLOUD AND ITS SOLAR SOURCE ON 2013 APRIL 11–14
Authors: Vemareddy P. , Möstl C. , Amerstorfer T. , Mishra W. , Farrugia C. , Leitner M. 
Published: August 2016

ABSTRACT
In the context of the Sun–Earth connection of coronal mass ejections and magnetic flux ropes (MFRs), we studied the solar active region (AR) and the magnetic properties of magnetic cloud (MC) event during 2013 April 14–15. We use in situ observations from the Advanced Composition Explorer and source AR measurements from the Solar Dynamics Observatory. The MCs magnetic structure is reconstructed from the Grad–Shafranov method, which reveals a northern component of the axial field with left handed helicity. The MC invariant axis is highly inclined to the ecliptic plane pointing northward and is rotated by 117° with respect to the source region PIL. The net axial flux and current in the MC are comparatively higher than from the source region. Linear force-free alpha distribution (10−7–10−6 m−1) at the sigmoid leg matches the range of twist number in the MC of 1–2 au MFR. The MFR is nonlinear force-free with decreasing twist from the axis (9 turns/au) toward the edge. Therefore, a Gold–Hoyle (GH) configuration, assuming a constant twist, is more consistent with the MC structure than the Lundquist configuration of increasing twist from the axis to boundary. As an indication of that, the GH configuration yields a better fitting to the global trend of in situ magnetic field components, in terms of rms, than the Lundquist model. These cylindrical configurations improved the MC fitting results when the effect of self-similar expansion of MFR was considered. For such twisting behavior, this study suggests an alternative fitting procedure to better characterize the MC magnetic structure and its source region links.
BARYON LOADING EFFICIENCY AND PARTICLE ACCELERATION EFFICIENCY OF RELATIVISTIC JETS: CASES FOR LOW LUMINOSITY BL LACS
Authors: Inoue Yoshiyuki , Tanaka Yasuyuki T. 
Published: August 2016

ABSTRACT
Relativistic jets launched by supermassive black holes, so-called active galactic nuclei (AGNs), are known as the most energetic particle accelerators in the universe. However, the baryon loading efficiency onto the jets from the accretion flows and their particle acceleration efficiencies have been veiled in mystery. With the latest data sets, we perform multi-wavelength spectral analysis of quiescent spectra of 13 TeV gamma-ray detected high-frequency-peaked BL Lacs (HBLs) following one-zone static synchrotron self-Compton (SSC) model. We determine the minimum, cooling break, and maximum electron Lorentz factors following the diffusive shock acceleration (DSA) theory. We find that HBLs have

and the radiative efficiency

, where P

B
and P

e
is the Poynting and electron power, respectively. By assuming 10 leptons per one proton, the jet power relates to the black hole mass as

, where

and

is the jet power and the Eddington luminosity, respectively. Under our model assumptions, we further find that HBLs have a jet production efficiency of

and a mass loading efficiency of

. We also investigate the particle acceleration efficiency in the blazar zone by including the most recent Swift/BAT data. Our samples ubiquitously have particle acceleration efficiencies of

, which is inefficient to accelerate particles up to the ultra-high-energy-cosmic-ray (UHECR) regime. This implies that the UHECR acceleration sites should not be the blazar zones of quiescent low power AGN jets, if one assumes the one-zone SSC model based on the DSA theory.
ASSESSMENT OF MODELS OF GALACTIC THERMAL DUST EMISSION USING COBE/FIRAS AND COBE/DIRBE OBSERVATIONS
Authors: Odegard N. , Kogut A. , Chuss D. T. , Miller N. J. 
Published: August 2016

ABSTRACT
Accurate modeling of the spectrum of thermal dust emission at millimeter wavelengths is important for improving the accuracy of foreground subtraction for cosmic microwave background (CMB) measurements, for improving the accuracy with which the contributions of different foreground emission components can be determined, and for improving our understanding of dust composition and dust physics. We fit four models of dust emission to high Galactic latitude COBE/FIRAS and COBE/DIRBE observations from 3 mm to 100 μm and compare the quality of the fits. We consider the two-level systems (TLS) model because it provides a physically motivated explanation for the observed long wavelength flattening of the dust spectrum and the anti-correlation between emissivity index and dust temperature. We consider the model of Finkbeiner et al. because it has been widely used for CMB studies, and the generalized version of this model that was recently applied to Planck data by Meisner and Finkbeiner. For comparison we have also fit a phenomenological model consisting of the sum of two graybody components. We find that the two-graybody model gives the best fit and the FDS model gives a significantly poorer fit than the other models. The Meisner and Finkbeiner model and the TLS model remain viable for use in Galactic foreground subtraction, but the FIRAS data do not have a sufficient signal-to-noise ratio to provide a strong test of the predicted spectrum at millimeter wavelengths.
RELATIVISTIC ELECTRONS PRODUCED BY RECONNECTING ELECTRIC FIELDS IN A LASER-DRIVEN BENCH-TOP SOLAR FLARE
Authors: Zhong J. Y. , Lin J. , Li Y. T. , Wang X. , Li Y. , Zhang K. , Yuan D. W. , Ping Y. L. , Wei H. G. , Wang J. Q. , Su L. N. , Li F. , Han B. , Liao G. Q. , Yin C. L. , Fang Y. , Yuan X. , Wang C. , Sun J. R. , Liang G. Y. , Wang F. L. , Ding Y. K. , He X. T. , Zhu J. Q. , Sheng Z. M. , Li G. , Zhao G. , Zhang J. 
Published: August 2016

ABSTRACT
Laboratory experiments have been carried out to model the magnetic reconnection process in a solar flare with powerful lasers. Relativistic electrons with energy up to megaelectronvolts are detected along the magnetic separatrices bounding the reconnection outflow, which exhibit a kappa-like distribution with an effective temperature of ∼109 K. The acceleration of non-thermal electrons is found to be more efficient in the case with a guide magnetic field (a component of a magnetic field along the reconnection-induced electric field) than in the case without a guide field. Hardening of the spectrum at energies ≥500 keV is observed in both cases, which remarkably resembles the hardening of hard X-ray and γ-ray spectra observed in many solar flares. This supports a recent proposal that the hardening in the hard X-ray and γ-ray emissions of solar flares is due to a hardening of the source-electron spectrum. We also performed numerical simulations that help examine behaviors of electrons in the reconnection process with the electromagnetic field configurations occurring in the experiments. The trajectories of non-thermal electrons observed in the experiments were well duplicated in the simulations. Our numerical simulations generally reproduce the electron energy spectrum as well, except for the hardening of the electron spectrum. This suggests that other mechanisms such as shock or turbulence may play an important role in the production of the observed energetic electrons.