bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mining medical related temporal information from patients’ self-description
Authors: Zhu Lichao , Yang Hangzhou , Yan Zhijun 
Published: November 2017

Purpose
The purpose of this paper is to develop a new method to extract medical temporal information from online health communities.

Design/methodology/approach
The authors trained a conditional random-filed model for the extraction of temporal expressions. The temporal relation identification is considered as a classification task and several support vector machine classifiers are built in the proposed method. For the model training, the authors extracted some high-level semantic features including co-reference relationship of medical concepts and the semantic similarity among words.

Findings
For the extraction of TIMEX, the authors find that well-formatted expressions are easy to recognize, and the main challenge is the relative TIMEX such as “three days after onset”. It also shows the same difficulty for normalization of absolute date or well-formatted duration, whereas frequency is easier to be normalized. For the identification of DocTimeRel, the result is fairly well, and the relation is difficult to identify when it involves a relative TIMEX or a hypothetical concept.

Originality/value
The authors proposed a new method to extract temporal information from the online clinical data and evaluated the usefulness of different level of syntactic features in this task.
Fake and pirated: do consumers care?
Authors: Chaudhry Peggy E. , Cesareo Ludovica 
Published: November 2017

Purpose
The purpose of this paper is to demonstrate the efficacy of messages in anti-counterfeiting campaigns that use a fear of legal prosecution, role models, peer pressure, linkages to organized crime and education.

Design/methodology/approach
A web survey of consumer perceptions regarding the effectiveness of different anti-counterfeiting campaigns on complicity was administered to 1,786 consumers in Brazil, China, India, Russia and the USA.

Findings
The effectiveness of the different anti-counterfeiting campaigns varies by country. Some can be used more successfully than others to limit complicity with the goal to transform consumers from accomplices of infringers to advocates of authenticity.

Research limitations/implications
An unexpected finding of this study was that several of the anti-counterfeiting campaigns were perceived as effective by consumers who reside in countries, such as China, that are well known for flourishing domestic counterfeit markets. Thus, these exploratory results provide a starting point for future researchers and practitioners to create and evaluate the efficacy of messages in anti-counterfeiting campaigns in markets where counterfeits and pirated goods are readily accessible in both physical and virtual markets.

Originality/value
Prior research establishes why consumers accept counterfeit and pirated products and also suggests a number of strategies to decrease its occurrence, mostly from a managerial perspective. This is the first multi-country study to assess whether consumers believe anti-counterfeiting campaigns will curb product counterfeiting.
Corporate social innovation: an Indian moving company drives industry change
Authors: Jayakumar Tulsi 
Published: November 2017

Purpose
This paper aims to understand how emerging economy firms can use the growing emphasis on corporate social responsibility (CSR) and sustainability as an opportunity to drive corporate social innovations (CSIs) so as to create shared value and gain competitive advantage.

Design/methodology/approach
The paper applies a case study design. Building on in-depth interviews with company officials, document analysis and secondary sources, the paper presents a model of CSIs.

Findings
The case study presents evidence of how Agarwal Packers and Movers Limited – an Indian family managed business firm operating in the fragmented, unorganized and highly competitive household relocation segment of the Indian logistics industry – used socio-environmental sustainability challenges to drive CSIs. These innovations helped it to differentiate itself from competitors and gain competitive advantage, while creating shared value simultaneously.

Practical implications
Indian firms have been lagging behind on both sustainability/CSR and innovations. Driven by domestic regulatory requirements, as also the need to compete in a globalizing economy, emerging economy firms may strategize to integrate their sustainability agenda with innovations to influence both organizational and societal outcomes.

Originality/value
Firm innovations, even in advanced countries, have been driven by market triggers, with ideas internal to the firm. The paper contributes to the limited research on innovations in emerging economy firms and shows how they may “leapfrog” their growth pathways by systematically integrating their sustainability agenda with innovation activities.
Purchasing food to counteract Mafia in Italy
Authors: Rivaroli Sergio , Ruggeri Arianna , Novi Pietro , Spadoni Roberta 
Published: November 2017

Purpose
The paper aims to investigate pro-social behaviour of Italian consumers during the decision-making process of buying food produced in lands confiscated from Mafia-type organisations. This is assumed as a form of buycotting, thus as an ethical purchasing choice to contribute to social change.

Design/methodology/approach
Data from 339 interviews were elaborated with a cluster analysis. The difference between groups was confirmed using MANOVA, whereas the multivariate multiple regression analysis was carried out to assess the difference between clusters.

Findings
Three types of consumer groups are identified: absolutists, exceptionists and subjectivists. Coherent with previous studies, findings also highlight the relevance of information acquisition and of the self-effectiveness perception as key factors to stimulate pro-social behaviours.

Originality/value
With a social marketing perspective, the paper offers useful suggestions to promote political consumerism as a critical choice to contribute to fight against Mafia-type organisations and to spread a culture of lawfulness.
Telephone discharge support for frail, vulnerable older people discharged from hospital: Impact on readmission rates – Participant and general practitioner feedback
Authors: Heppenstall Claire P , Hanger Hugh C , Wilkinson Timothy J , Dhanak Michelle 
Published: November 2017

ObjectiveTo assess the use and acceptability to older participants and general practitioners (GPs) of telephone support postdischarge to reduce readmissions.MethodsA prospective cohort study of older people after discharge from a specialist geriatric unit, and comparison with a previous cohort. Telephone follow‐up calls were made fortnightly for three months. Structured questionnaires were used to obtain feedback from participants and GPs.ResultsReadmission rates were high, 40%, despite the intervention. This rate had significantly increased since the earlier cohort. Almost one‐fifth of the sample (19%) were readmitted before the first telephone call. Subsequent readmissions were not related to whether participants had reported deteriorating health during the preceding telephone call. Feedback on the intervention from both participants and GPs was supportive.ConclusionsTelephone follow‐up as we used it did not reduce readmission rates. However, it was well received and appreciated by participants. It is possible the telephone calls were not made early enough or frequently enough to achieve the desired outcome.
China's Belt and Road Initiative: Can Europe Expect Trade Gains?
Authors: Herrero Alicia Garcia , Xu Jianwei 
Published: November 2017

AbstractThe Belt and Road Initiative (BRI) aims to improve cross‐border infrastructure to reduce transportation costs across a massive geographical area between China and Europe. We estimate how much trade might be created among Belt and Road (B&R) countries as a consequence of the reduction in transportation costs (both railway and maritime) and find that European Union countries, especially landlocked countries, will benefit considerably. This is also true for Eastern Europe and Central Asia and, to a lesser extent, South‐East Asia. In contrast, if China were to seek to establish a free trade area within the B&R region, EU member states would benefit less, while Asia would benefit more. Xi Jinping's current vision for the B&R, centered on improving transport infrastructure, is advantageous for Europe as far as trade creation is concerned.
Case Report: A Cryptosporidium infection in a patient with relapsed T‐lymphoblastic lymphoma undergoing allogeneic stem cell transplantation
Authors: Schiller Joanna , Klein Sebastian , Engels Marianne , Büttner Reinhard , Rybniker Jan , Fätkenheuer Gerd , Scheid Christof , Wybranski Christian , Quaas Alexander , Reinhardt Hans Christian , Flümann Ruth 
Published: November 2017

AbstractCryptosporidium infection is a rare cause of enterocolitis. In immunocompromised patients, cryptosporidiosis may lead to debilitating and life‐threatening diarrhea and malabsorption, occasionally with multi‐organ involvement. Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) requires long‐term immunosuppressive therapy, while cellular immunity is usually compromised due to intensive conditioning chemotherapy. Diarrhea in patients who underwent allo‐HSCT may be a sign of an infection, but can also be the result of intestinal graft‐versus‐host disease (GvHD). Here, we describe the case of a patient who developed severe diarrhea following allo‐HSCT for relapsed T‐lymphoblastic lymphoma. Initially, GvHD was suspected and treatment was initiated accordingly. However, a colon biopsy showed signs of cryptosporide oocysts alongside only low‐grade GvHD. Following molecular confirmation of the diagnosis of cryptosporidiosis, an intensive treatment regimen was started. Despite the severe clinical course, the patient recovered and was discharged with only residual symptoms.
Patterns and drivers of fish extirpations in rivers of the American Southwest and Southeast
Authors: Kominoski John S. , Ruhí Albert , Hagler Megan M. , Petersen Kelly , Sabo John L. , Sinha Tushar , Sankarasubramanian Arumugam , Olden Julian D. 
Published: November 2017

AbstractEffective conservation of freshwater biodiversity requires spatially explicit investigations of how dams and hydroclimatic alterations among climate regions may interact to drive species to extinction. We investigated how dams and hydroclimatic alterations interact with species ecological and life history traits to influence past extirpation probabilities of native freshwater fishes in the Upper and Lower Colorado River (CR), Alabama‐Coosa‐Tallapoosa (ACT), and Apalachicola‐Chattahoochee‐Flint (ACF) basins. Using long‐term discharge data for continuously gaged streams and rivers, we quantified streamflow anomalies (i.e., departure “expected” streamflow) at the sub‐basin scale over the past half‐century. Next, we related extirpation probabilities of native fishes in both regions to streamflow anomalies, river basin characteristics, species traits, and non‐native species richness using binomial logistic regression. Sub‐basin extirpations in the Southwest (n = 95 Upper CR, n = 130 Lower CR) were highest in lowland mainstem rivers impacted by large dams and in desert springs. Dampened flow seasonality, increased longevity (i.e., delayed reproduction), and decreased fish egg sizes (i.e., lower parental care) were related to elevated fish extirpation probability in the Southwest. Sub‐basin extirpations in the Southeast (ACT n = 46, ACF n = 22) were most prevalent in upland rivers, with flow dependency, greater age and length at maturity, isolation by dams, and greater distance upstream. Our results confirm that dams are an overriding driver of native fish species losses, irrespective of basin‐wide differences in native or non‐native species richness. Dams and hydrologic alterations interact with species traits to influence community disassembly, and very high extirpation risks in the Southeast are due to interactions between high dam density and species restricted ranges. Given global surges in dam building and retrofitting, increased extirpation risks should be expected unless management strategies that balance flow regulation with ecological outcomes are widely implemented.
Large‐scale migrations of brown bears in Eurasia and to North America during the Late Pleistocene
Authors: Anijalg Peeter , Ho Simon Y. W. , Davison John , Keis Marju , Tammeleht Egle , Bobowik Katalina , Tumanov Igor L. , Saveljev Alexander P. , Lyapunova Elena A. , Vorobiev Alexandr A. , Markov Nikolai I. , Kryukov Alexey P. , Kojola Ilpo , Swenson Jon E. , Hagen Snorre B. , Eiken Hans Geir , Paule Ladislav , Saarma Urmas 
Published: November 2017

AbstractAimClimatic changes during the Late Pleistocene had major impacts on populations of plant and animal species. Brown bears and other large mammals are likely to have experienced analogous ecological pressures and phylogeographical processes. Here, we address several unresolved issues regarding the Late Pleistocene demography of brown bears: (1) the putative locations of refugia; (2) the direction of migrations across Eurasia and into North America; and (3) parallels with the demographic histories of other wild mammals and modern humans.LocationEurasia and North America.MethodsWe sequenced 110 complete mitochondrial genomes from Eurasian brown bears and combined these with published sequences from 138 brown bears and 33 polar bears. We used a Bayesian approach to obtain a joint estimate of the phylogeny and evolutionary divergence times. The inferred mutation rate was compared with estimates obtained using two additional methods.ResultsBayesian phylogenetic analysis identified seven clades of brown bears, with most individuals belonging to a very large Holarctic clade. Bears from the widespread clade 3a1, which has a distribution from Europe across Asia to Alaska, shared a common ancestor about 45,000 years ago.Main conclusionsWe suggest that the Altai‐Sayan region and Beringia were important Late Pleistocene refuge areas for brown bears and propose large‐scale migration scenarios for bears in Eurasia and to North America. We also argue that brown bears and modern humans experienced a demographic standstill in Beringia before colonizing North America.
An All‐Zirconia Crown Discovered 2 Years Following Aspiration
Authors: Qin Han , Qing Hai , Hu Na , Zhu Hui , Wang Jian 
Published: November 2017

AbstractAccidental aspiration or ingestion can occur in dental treatment, as most procedures are performed with the patient in a supine position or semi‐recumbent position. Aspiration of foreign bodies commonly causes acute symptoms such as violent coughing, choking, and dyspnea; however, if foreign bodies are stuck distally to the lower lobe bronchi or the bronchus intermedius, acute presentation can be rare. This clinical report documents a 68‐year‐old male patient who accidentally aspirated an all‐zirconia crown during the try‐in procedure. The case was initially surmised as ingestion. The crown remained in the lower lobe of the left lung for about 2 years without any significant symptoms. This report cautions the importance of airway protection during dental procedures.
Tilmicosin‐ and florfenicol‐loaded hydrogenated castor oil‐solid lipid nanoparticles to pigs: Combined antibacterial activities and pharmacokinetics
Authors: Ling Z. , Yonghong L. , Junfeng L. , Li Z. , Xianqiang L. 
Published: November 2017

The combined antibacterial effects of tilmicosin (TIL) and florfenicol (FF) against Actinobacillus pleuropneumoniae (APP) (n = 2), Streptococcus suis (S. suis) (n = 2), and Haemophilus parasuis (HPS) (n = 2) were evaluated by chekerboard test and time‐kill assays. The pharmacokinetics (PKs) of TIL‐ and FF‐loaded hydrogenated castor oil (HCO)‐solid lipid nanoparticles (SLN) were performed in healthy pigs. The results indicated that TIL and FF showed synergistic or additive antibacterial activities against APP, S. suis and HPS with the fractional inhibitory concentration (FIC) ranging from 0.375 to 0.75. The time‐kill assays showed that 1/2 minimum inhibitory concentration (MIC) TIL combined with 1/2 MIC FF had a stronger ability to inhibit the growth of APP, S. suis, and HPS than 1 MIC TIL or 1 MIC FF, respectively. After oral administration, plasma TIL and FF concentrations could maintain about 0.1 μg/ml for 192 and 176 hr. The SLN prolonged the last time point with detectable concentrations (Tlast), area under the concentration–time curve (AUC0‐t), elimination half‐life (T½ke), and mean residence time (MRT) by 3.1, 5.6, 12.7, 3.4‐fold of the active pharmaceutical ingredient (API) of TIL and 11.8, 16.5, 18.1, 12.1‐fold of the API of FF, respectively. This study suggests that the TIL‐FF‐SLN could be a useful oral formulation for the treatment of APP, S. suis, and HPS infection in pigs.
Rectal administration of vigabatrin achieves higher plasma concentration than oral administration
Authors: Hussein Omar , Sawalha Khalid , Kalra Arun 
Published: November 2017

AbstractVigabatrin is a synthetic GABA derivative that is used to treat infantile spasms and as an adjunctive therapy in resistant cases of epilepsy. We present an 18‐month‐old white male with a history of infantile spasms, very well controlled on oral phenobarbital, and vigabatrin 55 mg/kg BID, who was admitted for urgent surgical management of esophageal obstruction. Vigabatrin is known to be administered orally only with a bioavailability of 80%. As oral administration was not possible, the medicine was crushed and dissolved in 15 cc of water to be administered rectally. The patient achieved serum level three times higher than the oral route. Our case suggests that rectal administration of vigabatrin might be an efficient route to achieve therapeutic drug‐plasma level.
Members of the DEAL subfamily of the DUF1218 gene family are required for bilateral symmetry but not for dorsoventrality in Arabidopsis leaves
Authors: Wilson‐Sánchez David , Martínez‐López Sebastián , Navarro‐Cartagena Sergio , Jover‐Gil Sara , Micol José Luis 
Published: November 2017

Summary

Most plant leaves exhibit bilateral symmetry, which has been hypothesized as an inevitable consequence of the existence of the proximodistal and dorsoventral axes. No gene has been described that affects leaf bilateral symmetry but not dorsoventrality in Arabidopsis thaliana.

We screened for viable insertional mutations that affect leaf morphology, and out of more than 700 mutants found only one, desigual1‐1 (deal1‐1), that exhibited bilateral symmetry breaking but no obvious defects in dorsoventrality. We found that deal1‐1 is an allele of VASCULATURE COMPLEXITY AND CONNECTIVITY (VCC).

Several overlapping regulatory pathways establish the interspersed lobes and indentations along the margin of Arabidopsis thaliana leaves. These pathways involve feedback loops of auxin, the PIN‐FORMED1 (PIN1) auxin efflux carrier, and the CUP‐SHAPED COTYLEDON2 (CUC2) transcriptional regulator. Early vcc (deal1) leaf primordia fail to acquire bilateral symmetry and instead form ectopic lobes and sinuses. The vcc leaves show aberrant recruitment of marginal cells expressing properly polarized PIN1, resulting in misplaced auxin maxima. Normal PIN1 polarization requires CUC2 expression and CUC2 genetically interacts with VCC; VCC also affects CUC2 expression.

VCC has a domain of unknown function, DUF1218, and localizes to the endoplasmic reticulum membrane. VCC acts partially redundantly with its two closest paralogs, DEAL2 and DEAL3, in early leaf margin patterning and is required for bilateral symmetry, but its loss of function does not visibly affect dorsoventrality.
Phenotypic characteristics associated with slow gait speed in idiopathic pulmonary fibrosis
Authors: Nolan Claire M. , Maddocks Matthew , Maher Toby M. , Canavan Jane L. , Jones Sarah E. , Barker Ruth E. , Patel Suhani , Jacob Joseph , Cullinan Paul , Man William D.‐C. 
Published: November 2017

ABSTRACTBackground and objectiveUsual gait speed over 4 m (4MGS) is an established functional performance measure in older adults that consistently predicts adverse health outcomes, but few data exist in idiopathic pulmonary fibrosis (IPF). We assessed the reliability of 4MGS, its relationship with established outcome measures and its responsiveness to pulmonary rehabilitation.MethodsIn four prospective IPF cohorts, 4MGS inter‐observer (n = 46) and test–retest (n = 46) reliability, concurrent validity (n = 65 and n = 62) and responsiveness (n = 60) were determined. The phenotypic characteristics of all patients stratified according to slow 4MGS (<0.8 m/s) were compared, including lung function parameters, HRCT of the chest, 6‐min walking distance (6MWD), Medical Respiratory Council (MRC) dyspnoea score, King’s Brief Interstitial Lung Disease (KBILD) questionnaire and Gender, Age and lung Physiology (GAP) prognostic index.ResultsIntra‐class correlation coefficients for inter‐observer and test–retest reliability were 0.996 and 0.983, respectively. There was a strong association between 4MGS and 6MWD (r = 0.76; P < 0.0001) and moderate correlations with MRC (r = −0.56), KBILD (r = 0.44) and GAP index (r = −0.41); all P < 0.005. 4MGS improved significantly with pulmonary rehabilitation (mean (95% CI) change: 0.16 (0.12–0.20) m/s), effect size 0.65. Patients with slow 4MGS had significantly worse exercise performance (6MWD: −167 (−220 to −133) m), dyspnoea, health status and prognosis index than those with preserved 4MGS, despite similar lung function and HRCT parameters.Conclusion4MGS is a simple, reliable, valid and responsive tool that may detect a patient phenotype with worse exercise performance, dyspnoea, health status and prognosis index in stable IPF.
Potential Exposure and Cancer Risk from Formaldehyde Emissions from Installed Chinese Manufactured Laminate Flooring
Authors: Sheehan Patrick , Singhal Ankur , Bogen Kenneth T. , MacIntosh David , Kalmes Renee M. , McCarthy John 
Published: November 2017

AbstractLumber Liquidators (LL) Chinese‐manufactured laminate flooring (CLF) has been installed in >400,000 U.S. homes over the last decade. To characterize potential associated formaldehyde exposures and cancer risks, chamber emissions data were collected from 399 new LL CLF, and from LL CLF installed in 899 homes in which measured aggregate indoor formaldehyde concentrations exceeded 100 μg/m3 from a total of 17,867 homes screened. Data from both sources were combined to characterize LL CLF flooring‐associated formaldehyde emissions from new boards and installed boards. New flooring had an average (±SD) emission rate of 61.3 ± 52.1 μg/m2‐hour; >one‐year installed boards had ∼threefold lower emission rates. Estimated emission rates for the 899 homes and corresponding data from questionnaires were used as inputs to a single‐compartment, steady‐state mass‐balance model to estimate corresponding residence‐specific TWA formaldehyde concentrations and potential resident exposures. Only ∼0.7% of those homes had estimated acute formaldehyde concentrations >100 μg/m3 immediately after LL CLF installation. The TWA daily formaldehyde inhalation exposure within the 899 homes was estimated to be 17 μg/day using California Proposition 65 default methods to extrapolate cancer risk (below the regulation “no significant risk level” of 40 μg/day). Using a U.S. Environmental Protection Agency linear cancer risk model, 50th and 95th percentile values of expected lifetime cancer risk for residents of these homes were estimated to be 0.33 and 1.2 per 100,000 exposed, respectively. Based on more recent data and verified nonlinear cancer risk assessment models, LL CLF formaldehyde emissions pose virtually no cancer risk to affected consumers.