bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predisposing factors for poor prognosis of angiosarcoma of the scalp and face: Systematic review and meta‐analysis
Authors: Shin Jin Yong , Roh Si‐Gyun , Lee Nae‐Ho , Yang Kyung‐Moo 
Published: August 2016

ABSTRACTBackgroundAngiosarcoma of the scalp and face is an aggressive tumor with a high rate of local recurrence. Although many previous studies have demonstrated risk factors for poor prognosis, debate remains. We identified the predisposing factors for poor prognosis through comprehensive review of selected studies with meta‐analysis.MethodsA systematic literature review and meta‐analysis were performed using MEDLINE, EMBASE, and Cochrane databases. Nine variables were extracted from the included studies and evaluated based on a 5‐year survival rate. The Newcastle–Ottawa scale was used to assess the quality of the studies.ResultsThe search strategy identified 89 publications. After screening, 11 articles were selected for review. Age, size, site of tumor, margin status, and surgery associated with poor angiosarcoma prognosis were identified.ConclusionAlthough further investigation of long‐term and prospective studies is needed, we identified 5 variables as predisposing factors for poor prognosis of angiosarcoma through meta‐analysis. © 2016 Wiley Periodicals, Inc. Head Neck 39: 380–386, 2017
Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults
Authors: Boon Eline , van der Graaf Winette T. A. , Gelderblom Hans , Tesselaar Margot E. T. , van Es Robert J. J. , Oosting Sjoukje F. , de Bree Remco , van Meerten Esther , Hoeben Ann , Smeele Ludi E. , Willems Stefan M. , Witjes Max J. H. , Buter Jan , Baatenburg de Jong Robert J. , Flucke Uta E. , Peer Petronella G. M. , Bovée Judith V. M. G. , Van Herpen Carla M. L. 
Published: August 2016

AbstractBackgroundThere is an ongoing debate about the value of (neo‐)adjuvant chemotherapy in high‐ and intermediate‐grade osteosarcoma of the head and neck.MethodsAll records of patients older than 16 years diagnosed with osteosarcoma of the head and neck in the Netherlands between 1993 and 2013 were reviewed.ResultsWe identified a total of 77 patients with an osteosarcoma of the head and neck; the 5‐year overall survival (OS) was 55%. In 50 patients with surgically resected high‐ or intermediate‐grade osteosarcoma of the head and neck younger than 75 years, univariate and multivariable analysis, adjusting for age and resection margins, showed that patients who had not received chemotherapy had a significantly higher risk of local recurrence (hazard ratio [HR] = 3.78 and 3.66, respectively).ConclusionIn patients younger than 75 years of age with surgically resected high‐ and intermediate‐grade osteosarcoma of the head and neck, treatment with (neo‐)adjuvant chemotherapy resulted in a significantly smaller risk of local recurrence. Therefore, we suggest (neo‐)adjuvant chemotherapy in patients amenable to chemotherapy. © 2016 The Authors Head & Neck Published by Wiley Periodicals, Inc. Head Neck 39: 140–146, 2017
Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells
Authors: Das Lipsa , Anderson Todd A. , Gard Jaime M.C. , Sroka Isis C. , Strautman Stephanie R. , Nagle Raymond B. , Morrissey Colm , Knudsen Beatrice S. , Cress Anne E. 
Published: August 2016

ABSTRACTLaminin binding integrins α6 (CD49f) and α3 (CD49c) are persistently but differentially expressed in prostate cancer (PCa). Integrin internalization is an important determinant of their cell surface expression and function. Using flow cytometry, and first order kinetic modeling, we quantitated the intrinsic internalization rates of integrin subunits in a single cycle of internalization. In PCa cell line DU145, α6 integrin internalized with a rate constant (kactual) of 3.25 min−1, threefold faster than α3 integrin (1.0 min−1), 1.5‐fold faster than the vitronectin binding αv integrin (CD51) (2.2 min−1), and significantly slower than the unrelated transferrin receptor (CD71) (15 min−1). Silencing of α3 integrin protein expression in DU145, PC3, and PC3B1 cells resulted in up to a 1.71‐fold increase in kactual for α6 integrin. The internalized α6 integrin was targeted to early endosomes but not to lamp1 vesicles. Depletion of α3 integrin expression resulted in redistribution of α6β4 integrin to an observed cell–cell staining pattern that is consistent with a suprabasal distribution observed in epidermis and early PIN lesions in PCa. Depletion of α3 integrin increased cell migration by 1.8‐fold, which was dependent on α6β1 integrin. Silencing of α6 integrin expression however, had no significant effect on the kactual of α3 integrin or its distribution in early endosomes. These results indicate that α3 and α6 integrins have significantly different internalization kinetics and that coordination exists between them for internalization. J. Cell. Biochem. 118: 1038–1049, 2017. © 2016 Wiley Periodicals, Inc.
Deep into the Aristolochia Flower: Expression of C, D, and E‐Class Genes inAristolochia fimbriata(Aristolochiaceae)
Authors: Suárez‐Baron Harold , Pérez‐Mesa Pablo , Ambrose Barbara A. , González Favio , Pabón‐Mora Natalia 
Published: August 2016

ABSTRACTAristolochia fimbriata(Aristolochiaceae) is a member of an early diverging lineage of flowering plants and a promising candidate for evo‐devo studies.Aristolochiaflowers exhibit a unique floral synorganization that consists of a monosymmetric and petaloid calyx formed by three congenitally fused sepals, and a gynostemium formed by the congenital fusion between stamens and the stigmatic region of the carpels. This floral ground plan atypical in the magnoliids can be used to evaluate the role of floral organ identity MADS‐box genes during early flower evolution. In this study, we present in situ hybridization experiments for the homologs of the canonical C‐, D‐, and E‐class genes. Spatiotemporal expression of the C‐class geneAfimAGis restricted to stamens, ovary, and ovules, suggesting a conserved stamen and carpel identity function, consistent with that reported in core‐eudicots and monocots. The D‐class geneAfimSTKis detected in the anthers, the stigmas, the ovary, the ovules, the fruit, and the seeds, suggesting conserved roles in ovule and seed identity and unique roles in stamens, ovary, and fruit development. In addition,AfimSTKexpression patterns in areas of organ abscission and dehiscence zones suggest putative roles linked to senescence processes. We found that both E‐class genes are expressed in the anthers and the ovary; however,AfimSEP2exhibits higher expression compared toAfimSEP1. These findings provide a comprehensive picture of the ancestral expression patterns of the canonical MADS‐box floral organ identity genes and the foundations for further comparative analyses in other magnoliids.
One For Me, One For You: Cause‐Related Marketing with Buy‐One Give‐One Promotions
Authors: Hamby Anne 
Published: August 2016

ABSTRACTA Buy‐one Give‐one (BOGO) donation model features the donation of a physical entity and is a popular cause‐related marketing (CM) promotion format. Little is known about factors that underlie consumer response to BOGO‐format promotions. The current studies, collectively, indicate BOGO promotions evoke a concrete construal mindset [(Trope & Liberman ). Temporal construal. Psychological Review, 110, 403–421], which influences consumer response in a distinct manner: BOGO promotions enhance promotion attitudes and purchase intention when bundled with utilitarian products, and enhance consumer response through perceived helpfulness of the donated entity.
Nanoimplants that Enhance Human Capabilities: A Cognitive‐Affective Approach to Assess Individuals’ Acceptance of this Controversial Technology
Authors: Reinares‐Lara Eva , Olarte‐Pascual Cristina , Pelegrín‐Borondo Jorge , Pino Giovanni 
Published: August 2016

ABSTRACTNanotechnology enables the miniaturization of complex devices designed to enhance individuals’ physical and cognitive capabilities and, in the form of nanoimplants, their integration in the human body. It is unknown, however, whether people are willing or not to accept such devices. To shed light on this issue, this research used an extended version of the well‐known technology acceptance model (TAM), adding affective factors to the cognitive components already present in the model. Testing on a sample of 600 individuals yielded statistically significant effects on attitudes toward nanoimplants and intention to undergo nanoimplantation. Conclusions are drawn and implications are discussed.
Casein glycomacropeptide‐derived peptide IPPKKNQDKTE ameliorates high glucose‐induced insulin resistance in HepG2 cells via activation of AMPK signaling
Authors: Song Jia‐jia , Wang Qian , Du Min , Li Tian‐ge , Chen Bin , Mao Xue‐ying 
Published: August 2016

ScopeRecently, casein glycomacropeptide (GMP)‐derived peptide was found to possess potent antioxidant and anti‐inflammatory activities. In this study, the improvement effects and underlying molecular mechanisms of GMP‐derived peptide on hepatic insulin resistance were investigated.Methods and resultsThe peptide IPPKKNQDKTE was identified from GMP papain hydrolysates by LC‐ESI‐MS/MS. Effects of IPPKKNQDKTE on glucose metabolism and expression levels of the hepatic insulin signaling proteins in high glucose‐induced insulin‐resistant HepG2 cells were evaluated. Results showed that IPPKKNQDKTE dose‐dependently increased glucose uptake and intracellular glycogen in insulin‐resistant HepG2 cells without affecting cell viability. IPPKKNQDKTE increased the phosphorylation of Akt and GSK3β and decreased the expression levels of p‐GS, G6Pase and PEPCK. These IPPKKNQDKTE‐mediated protection effects were reversed by PI3K/Akt inhibitor LY294002, showing the mediatory role of PI3K/Akt. Moreover, treatment with IPPKKNQDKTE reduced IRS‐1 Ser307 phosphorylation and increased phosphorylation of AMPK. Knockdown AMPK using siRNA in HepG2 cells increased Ser307 phosphorylation of IRS‐1 and reduced Akt phosphorylation in IPPKKNQDKTE‐treated insulin‐resistant cells.ConclusionIPPKKNQDKTE prevents high glucose‐induced insulin resistance in HepG2 cells by modulating the IRS‐1/PI3K/Akt signaling pathway through AMPK activation, indicating that IPPKKNQDKTE plays a potential role in the prevention and treatment of hepatic insulin resistance and type 2 diabetes.
Novel type of isoprenoid membrane anchors: an investigation of binding properties with dipalmitoylphosphatidylcholine vesicles
Authors: Faizullin Dzhigangir A. , Dzyurkevich Mikhail S. , Valiullina Yuliya A. , Islamov Daut R. , Kataeva Olga N. , Zuev Yuriy F. , Plemenkov Vitaliy V. , Stoikov Ivan I. 
Published: August 2016

AbstractIn this work, we present a new type of amphiphilic membrane‐anchoring agents that can be easily obtained by the Diels‐Alder reaction between terpene myrcene and N‐substituted maleimides. The interaction between the compounds and small unilamellar dipalmitoylphosphatidylcholine vesicles was investigated using infrared spectroscopy, microgravimetry, and turbidimetry. The ability of the compounds to embed in the phospholipid membrane was shown to be strongly dependent on the charge of their polar group. The insertion of the compounds studied into the lipid bilayer did not lead to disruption of the dipalmitoylphosphatidylcholine vesicles up to the highest tested drug to lipid molar ratio of 0.5 to 0.6. Low lipid solubilization ability of the compounds as well as their rigid nonplanar structure makes them an interesting alternative to the common membrane‐anchoring structural motifs.
Did Amendments to the Ontario Highway Traffic Act in 2009-2010 Affect the Proportion of Alcohol-Related Motor Vehicle Collisions Seen at a Level I Trauma Centre over a 10-year Period?
Authors: Garnett Meghan , Charyk Stewart Tanya , Miller Michael R , Lim Rodrick , Van Aarsen Kristine , Millard Wanda 
Published: August 2016

AbstractObjectivesTo determine if changes to the Ontario Highway Traffic Act (OHTA) in 2009 and 2010 had an effect on the proportion of alcohol-related motor vehicle collisions (MVCs) presenting to a trauma centre over a 10-year period.MethodsA retrospective review of the trauma registry at a Level I trauma centre in southwestern Ontario was undertaken. The trauma registry is a database of all trauma patients with an injury severity score (ISS) ≥12 and/or who had trauma team activation. Descriptive statistics were calculated. Interrupted time series analyses with ARIMA modeling were performed on quarterly data from 2004-2013.ResultsA total of 377 drivers with a detectable serum ethanol concentration (SEC) were treated at our trauma centre over the 10-year period, representing 21% of all MVCs. The majority (330; 88%) were male. The median age was 31 years, median SEC was 35.3 mmol/L, and median ISS was 21. A total of 29 (7.7%) drinking drivers died from their injuries after arriving to hospital. There was no change in the proportion of drinking drivers after the 2009 amendment, but there was a significant decline in the average SEC of drinking drivers after changes to the law. There was no difference in the proportion of drinking drivers ≤21 years after introduction of the 2010 amendment for young and novice drivers.ConclusionsThere was a significance decline in the average SEC of all drinking drivers after the 2009 OHTA amendment, suggesting that legislative amendments may have an impact on drinking before driving behaviour.
WHEN LARGE CONFLICTS SUBSIDE: THE EBBS AND FLOWS OF VIOLENCE IN POST-SUHARTO INDONESIA
Authors: Barron Patrick , Jaffrey Sana , Varshney Ashutosh 
Published: August 2016

AbstractThe last decade has witnessed an extraordinary spate of scholarship on the ethno-communal violence that swept through Indonesia following the collapse of the Suharto regime. Yet we know very little about how these large-scale violent conflicts subsided and the patterns of post-conflict violence that have emerged since. We introduce evidence from an original dataset to show that the high violence period lasted till 2003, after which violence declined in intensity and scale. Despite this aggregate decline, we find that old conflict sites still exhibit relatively high levels of small-scale violence. We conclude that Indonesia has moved to a new, post-conflict phase where large-scale violence is infrequent, yet small-scale violence remains unabated, often taking on new forms. Finally, we propose that effective internal security interventions by the state are a key reason, although not the only reason, why large-scale violence has not emerged again despite the continued prevalence of low-level violence.
The Roman Frontier in Britain
Authors: Collingwood R. G. 
Published: August 2016

It was Augustus who first realized that the Roman Empire could not go on expanding for ever. Horace could writeCaelo tonantem credidimus IovemRegnare; praesens Divus habebiiurAugustus adiectis BritannisImperio gravibusque Persis;but a very real part of Augustus' claim to grateful veneration lay in the fact that he made up his mind to leave Britons and Parthians alone—to seek in them not new subjects, but peaceful and respectful neighbours.Coercere intra terminos imperiumwas the advice he left to his successors; and in principle they never departed from it. Claudius might conquer Britain, Trajan Mesopotamia and Dacia; but these were “rectifications,” as we say nowadays, not obliterations, of the imperial frontier.For the frontier of the Empire, as Augustus left it, was far from perfect. Tiberius, concerned above all to maintain intact the system created by Augustus, played here, as everywhere, a waiting game, and did not meddle with the Augustan frontiers. But his successor Gaius, or “Caligula,” may have contemplated a conquest, or at least an invasion, of Britain; he certainly made a demonstration on the shore of the Channel. And Claudius, the fourth Emperor, took the decisive step. Britain and Gaul were too close together, too intimately linked by geography, blood and civilization, to permit of an unfortified Channel frontier. Southern Britain was already in part Romanized, and the flag followed trade.
The Danube Thoroughfare and the Beginnings of Civilization in Europe
Authors: Childe V. Gordon 
Published: August 2016

While high civilizations were growing up in Mesopotamia, Egypt, and the Aegean, continental Europe was still recovering from an ice age. Though the glaciers had retreated, the high passes that led across the Alps from the favoured Mediterranean to the interior were still virtually closed by snow. The tundras and steppes where the men of the Old Stone Age had hunted the reindeer were now for the most part covered with a dense forest fostered by the damp climate then ruling. Through the belt of forest and mountain that fenced off northern and western Europe early man could not easily penetrate. To reach Britain or Denmark he must take ship and face the perils of the Atlantic in a dug-out canoe or some only slightly superior craft. But one moving road leads right into the heart of the continent. From the Black Sea to Bavaria the Danube opens out a passage way far safer than the stormy Atlantic. Moreover it leads into territories where the uncongenial primeval forest did not grow so densely nor so inhospitably as on the coasts or highlands.Large tracts in Central Europe are covered with a deep deposit of fine wind-born dust that had formed during the dry ice ages. This aeolian soil termed “löss” is unfavourable to the growth of heavy timber, incidentally it provides ideal agricultural land.
The Climate of Prehistoric Britain
Authors: Brooks C. E. P. 
Published: August 2016

After the latest glacial advance of the Quaternary Ice Age, the climate of north-west Europe did not simply recover to its present level, but underwent a series of fluctuations, at times becoming warmer and drier than at present, and again approaching glacial conditions. The pioneer in the investigation of these postglacial climatic changes was the Norwegian Axel Blytt, who as long ago as 1876 made out a succession of dry and wet periods, which he termed Boreal, Atlantic, sub-Boreal and sub-Atlantic. The existence of these four periods has been abundantly confirmed; they are best shown in the peat-bogs of Norway and Sweden, where they are represented by layers of tree-stools alternating with beds of peat, but they have now been connected with de Geer's geochronological time-scale derived from the banded glacial clays. It is found that the dry, mainly cool Boreal period extended from about 6500 to 5200 B.C., the moist warm Atlantic period from 5200 to 3000 B.c., the dry warm sub-Boreal from 3000 to 850 B.C., and the wet cool sub-Atlantic from 850 B.C., to about 300 A.D. Thus the Neolithic in north-west Europe falls partly in the Atlantic and partly in the sub-Boreal period; the Bronze Age entirely in the latter. The early Iron Age, on the other hand, falls mainly in the sub-Atlantic.A succession of dry and wet periods can be recognized over a wide area in northern and central Europe and again in Scotland and Ireland. The Swiss lake-dwellings are strong evidence of a dry climate during much of the Neolithic, because when they were established the levels of the lakes must have been very much lower than at present, especially if, as seems probable, the dwellings were first built not in the waters of the lakes but on peat-bogs on their Neolithic shores. In Scotland James Geikie obtained a sequence similar to Blytt's, though he stressed the changes of temperature rather than of rainfall. Geikie named his stages Lower Forestian, Lower Turbarian (i.e. Lower Peat), Upper Forestian and Upper Turbarian. The Scottish peat mosses have since been examined more closely by F. J. Lewis1, who found that the Upper Forest Bed extended over the whole mainland of Scotland almost to Cape Wrath, rising in places to nearly 3000 feet above sea level, or far above the present limit of trees. In the Highlands however it is split into two layers separated by one to three feet of peat, indicating a break in the dry conditions. It is interesting that a similar break in the dry Neolithic climate is shown by the history of the Swiss lake-dwellings. The Upper Forest layer is not found in the Shetlands.
Barrows
Authors: Crawford O. G. S. 
Published: August 2016

The fascination of Archaeology consists in reconstructing the life of the past, but by a curious paradox we obtain most of our raw material from the graves of the dead. We profit by the superstition which ordained that the dead man should be supplied with tools and weapons, and the dead woman with ornaments, to accompany them to the land of shadows. We profit also by the conservative instinct which regulated the construction of the tomb and the accompanying ritual. Nothing changes so slowly as burial-customs, even in these radical times. In all essentials the modern funeral procession remains Victorian in its gloomy respectability, its tawdry finery, and its obsolete methods of transport.The origin of barrow-making being unknown, one is free to speculate without the risk of being upset by evidence. The earliest deliberate burials occurred in the Mousterian period, in caves; and although connecting links are not numerous, one cannot help feeling that the natural cave must have been the ancestor of the megalithic passage-grave. In all essentials the cave and the passage-grave are the same; the 'points' so to speak, of a habitation cave are (I) the ground in front of the mouth, ( 2 ) the mouth, and (3) the dark, little used interior. Of these the mouth was the most important, and was often walled off; and it is natural to suppose that the darker recesses were used for sleeping in at night. These three features correspond fairly well with the typical arrangement of a passage-grave ; and if the houses of the dead were modelled upon those of the living, as is usually supposed, there may be some truth in this suggested evolution ; but there are many difficulties. However this may be, megalithic burial-places were very often—and always in our country—covered with mounds of earth or, in stony country, cairns of stone : they were in fact the first barrows ; so we must consider them. The subject is a very thorny one, and in order to avoid being drawn into argument, I shall avoid problems and keep to a description of facts. The title of this paper suggests that geographical and ethnographical deductions may for once be given second place.
The Swedish Excavations in Cyprus
Authors: Gjerstad Einar 
Published: August 2016

The Swedish archaeological expedition in Cyprus worked last year at Lapithos on the north and at Karavostassi, the ancient Soli, on the north-west.At Lapithos 23 tombs from the early and middle Copper Age and zo tombs from the early Iron Age were opened and examined. The former cover a period from the end of early Cypriote I to the beginning of middle Cypriote 11. The main part of the finds consists of a very representative series of pottery : red polished I-IV ware, black polished ware, black slip 1-11 ware, white painted I-IV ware. The later tombs have yielded a rich collection of tools and weapons, bracelets and rings of copper, finger-rings of silver and gold, 8 necklaces of paste beads, idols of terra cotta and one marble idol, etc. The gold rings (early Cypriote III) represent the first gold found in Cvprus of the early Copper Age. One necklace (early Cypriote III), coniists of 156 globular beads of various sizes arranged in 8 rhythmic series, with one large bead in the middle of each series. Another necklace (middle Cypriote I) consists of 64 large globular beads and more than 500 small cylindrical beads inserted between the large ones. A third is of round, fluted and double-conical beads in symmetrical arrangement. The idols are of the plank-shaped type. One represents a mother holding a baby in her arms, another a mother and a baby in a bed, and a third a man and a woman in a bed.