bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis
Authors: Dong Hui , Dumenil Jack , Lu Fu-Hao , Na Li , Vanhaeren Hannes , Naumann Christin , Klecker Maria , Prior Rachel , Smith Caroline , McKenzie Neil , Saalbach Gerhard , Chen Liangliang , Xia Tian , Gonzalez Nathalie , Seguela Mathilde , Inze Dirk , Dissmeyer Nico , Li Yunhai , Bevan Michael W. 
Published: December 2016

ABSTRACTThe characteristic shapes and sizes of organs are established by cell proliferation patterns and final cell sizes, but the underlying molecular mechanisms coordinating these are poorly understood. Here we characterize a ubiquitin-activated peptidase called DA1 that limits the duration of cell proliferation during organ growth inArabidopsis thaliana. The peptidase is activated by two RING E3 ligases, BB and DA2, which are subsequently cleaved by the activated peptidase and destabilized. In the case of BB, cleavage leads to destabilization by the RING E3 ligase PRT1 of the N-end rule pathway. DA1 peptidase activity also cleaves the de-ubiquitylase UBP15, which promotes cell proliferation, and the transcription factors TCP15 and TCP22, which promote cell proliferation proliferation and repress endoreduplication. We propose that DA1 peptidase activity regulates the duration of cell proliferation and the transition to endoreduplication and differentiation during organ formation in plants by coordinating the destabilization of regulatory proteins.
Telework: conditions that have a positive and negative impact on the work-family conflict
Authors: Solís Martín Salazar 
Published: December 2016

Purpose
Various investigations have shed light on the positive and negative effects of telework on the work-family conflict. These effects might be related to the conditions under which telework is carried out. The purpose of this paper is to analyze the influence of six variables related to telework conditions on the work-family conflict, and the number of additional hours worked beyond normal office hours.

Design/methodology/approach
Multiple linear regression models are calculated with data collected from a sample of 142 teleworkers in public institutions to evaluate the effect of the above variables.

Findings
Results reveal that factors which affect work-family conflict include the space used for working at home, the presence of persons at home while someone is teleworking, the number of days of telework, the time a person has been teleworking, and the extent of responsibility a worker has outside of the work environment.

Originality/value
There is a need for research to determine the ideal conditions and situations for teleworking. This study is specifically intended to strengthen some previous findings in this area, and to provide new evidence.
Trust and satisfaction: the keys to client loyalty in mobile commerce
Authors: Jimenez Nadia , San-Martin Sonia , Azuela Jose Ignacio 
Published: December 2016

Purpose
The purpose of this paper is to analyze the role of four important variables in the development of customer loyalty in mobile commerce. These variables are personal (propensity to use information and communication technologies (ICTs)), transactional (opportunism), and relational (trust and satisfaction).

Design/methodology/approach
A broad sample of 1,053 mobile customers in Mexico was studied using the structural equation analysis methodology.

Findings
The results offer evidence on how trust and satisfaction can increase loyalty and motivate purchases via mobile devices. In addition, the results show evidence of the indirect effect (mediated through trust) of opportunism, and propensity to use ICTs on loyalty.

Practical implications
Achieving customer satisfaction is revealed as the main strategy enterprises should seek in order to encourage repetitive purchases via mobile devices and customer loyalty. At the same time, companies should consider that the customers most likely to use ICTs, and those who perceive less opportunism can also be very loyal as a result of a higher level of trust when making purchases using mobile devices.

Originality/value
The contributions of this paper are: (1) to analyze the generation of loyalty in mobile commerce using a conceptual model that includes variables of different theoretical perspectives and nature, both positive and negative. (2) To provide empirical evidence from a sample of mobile users who have already bought goods via mobile phone, contributing to prior literature that has focused on analyzing the behavior of mobile phone users who do not make purchases via mobile phones. (3) To study mobile commerce in an emerging market with notable potential for growth (Mexico), which has not been studied at length in previous literature.
Inventory management in food companies with statistically dependent demand
Authors: Rojas Fernando , Leiva Victor 
Published: December 2016

Purpose
The objective of this paper is to propose a methodology based on random demand inventory models and dependence structures for a set of raw materials, referred to as “components”, used by food services that produce food rations referred to as “menus”.

Design/methodology/approach
The contribution margins of food services that produce menus are optimised using random dependent demand inventory models. The statistical dependence between the demand for components and/or menus is incorporated into the model through the multivariate Gaussian (or normal) distribution. The contribution margins are optimised by using probabilistic inventory models for each component and stochastic programming with a differential evolution algorithm.

Findings
When compared to the non-optimised system previously used by the company, the (average) expected contribution margin increases by 18.32 per cent when using a continuous review inventory model for groceries and uniperiodic models for perishable components (optimised system).

Research limitations/implications
The multivariate modeling can be improved by using (a) other non-Gaussian (marginal) univariate probability distributions, by means of the copula method that considers more complex statistical dependence structures; (b) time-dependence, through autoregressive time-series structures and moving average; (c) random modelling of lead-time; and (d) demands for components with values equal to zero using zero-inflated or adjusted probability distribution.

Practical implications
Professional management of the supply chain allows the users to register data concerning component identification, demand, and stock levels to subsequently be used with the proposed methodology, which must be implemented computationally.

Originality/value
The proposed multivariate methodology allows it to describe demand dependence structures through inventory models applicable to components used to produce menus in food services.
Becoming a leader-manager: a matter of training and education
Authors: Nguyen Nhien , Hansen Jens Ørding 
Published: December 2016

Purpose
Responding to a call from the conference “Becoming a leader: A matter of education?”, this paper aims to raise awareness of the challenge for individuals of performing both leadership and management activities and draws attention to the need for a new approach to educating and training leader-managers.

Design/methodology/approach
Based on the existing literature and discussions from the abovementioned conference, the paper questions the current approaches which either merge the leadership and management functions or treat them as mutually exclusive roles and offers instead a dual approach that emphasizes the capacity of individuals to switch mindsets.

Findings
Managing and leading are distinct activities with different goals and means that need to co-exist. Individuals should be prepared to either manage or lead depending on the situation and to change their mindset accordingly. Education and training programs should be designed for this purpose.

Originality/value
The paper proposes a dual “leading-managing mix” and discusses the challenges of its implementation by individuals. The discussion of the implications for training and education will be of value to practitioners as well as educators and training specialists.
Perspectives on informatics in the health sciences for information professionals
Authors: Frank Cervone H. 
Published: December 2016

Purpose
Informatics is a relatively new interdisciplinary field which is not very well understood outside of specific disciplinary communities. With a review of the history of informatics and a discussion of the various branches of informatics related to health-care practice, the paper aims to provide an overview designed to enhance the understanding of an information professional interested in this field.

Design/methodology/approach
The paper is designed to provide a basic introduction to the topic of informatics for information professionals unfamiliar with the field. Using a combination of historical and current sources, the role of informatics in the health professions is explored through its history and development.

Findings
The emergence of informatics as a discipline is a relatively recent phenomenon. Informatics is neither information technology (IT) nor information science but shares many common interests, concerns and techniques with these other two fields. The role of the informaticist is to transform data to knowledge and information. Consequently, while the outcomes may be different, there are many commonalities in informatics with the work information professionals perform.

Originality/value
Most introductions to informatics assume the reader is either an IT professional or a clinical practitioner in one of the health science fields. This paper takes a unique approach by positioning the discussion of the history and application of informatics in the health sciences from the perspective of the information professional.
Optimal feedback control of twin rotor MIMO system with a prescribed degree of stability
Authors: Choudhary Santosh Kumar 
Published: December 2016

Purpose
The purpose of this paper is to investigate an optimal control solution with prescribed degree of stability for the position and tracking control problem of the twin rotor multiple input-multiple output (MIMO) system (TRMS). The twin rotor MIMO system is a benchmark aerodynamical laboratory model having strongly non-linear characteristics and unstable coupling dynamics which make the control of such system for either posture stabilization or trajectory tracking a challenging task.

Design/methodology/approach
This paper first describes the dynamical model of twin rotor MIMO system (TRMS) and then it adopts linear-quadratic regulator (LQR)-based optimal control technique with prescribed degree of stability to achieve the desired trajectory or posture stabilization of TRMS.

Findings
The simulation results show that the investigated controller has both static and dynamic performance; therefore, the stability and the quick control effect can be obtained simultaneously for the twin rotor MIMO system.

Originality/value
The articles on LQR optimal controllers for TRMS can also be found in many literatures, but the prescribed degree of stability concept was not discussed in any of the paper. In this work, new LQR with the prescribed degree of stability concept is applied to provide an optimal control solution for the position and tracking control problem of TRMS.
Development of obstacle- avoiding robots using RF technology
Authors: B.B.V.L. Deepak , Nayak Soubhagya , Patra Sandip Kumar 
Published: December 2016

Purpose
In the capricious span of this current millennium, there is a deafening roar in the demand for modernization in the sector of robotics and technology to perform tasks in an intelligent manner. Thus to replenish such necessities, the innovations and inventions of researchers came forward as blessings on human civilization due to their sheer ingenuity and relentless and arduous efforts with each nanosecond passed from now onwards. With the same sublime goal, same resilient endeavor, same aggressive demeanor, the paper on obstacle avoiding robots comes forward. The paper aims to discuss these issues.

Design/methodology/approach
It exhibits how to control a differential drive robot wirelessly by analog thumb joystick module with added obstacle avoidance protection. The variations made by the user in the control of analog thumb joystick module are fed as input to the Atmega 16 microcontroller board which further transfers it wirelessly to the robot through the radio frequency (RF) transmitting module. The Arduino mega microcontroller equipped to the robot cross-checks the instructions gained through the RF receiving module and provides power accordingly to the geared motors through the motor driver board for movement along with scanning the environment to avoid obstacles present thereby.

Findings
The improvisation of RF technology in controlling the obstacle avoiding robot has enhanced its application and reliability by leaps and bounds reducing the anxiety and tension of the human controller.

Originality/value
With more advanced algorithm and genuine deployment sensors, the idea behind this research work can be used in humanoid robots which can help immensely in going to the extremely dangerous terrains, war zones and also in human rescue operations.
Experimental investigation and analysis of factors influencing delamination and surface roughness of hybrid GFRP laminates using Taguchi technique
Authors: Jenarthanan M.P. , Lakshman Prakash A. , Jeyapaul R. 
Published: December 2016

Purpose
The paper aims to develop a mathematical model for delamination and surface roughness during end milling by using response surface methodology (RSM) and to determine how the input parameters (cutting speed, depth of cut, helix angle and feed rate) influence the output response (delamination and surface roughness) in machining of hybrid glass fibre reinforced plastic (GFRP; Abaca and Glass) composite using solid carbide end mill cutter.

Design/methodology/approach
Four-factor, three-level Taguchi orthogonal array design in RSM is used to carry out the experimental investigation. The “Design Expert 8.0” is used to analyse the data collected graphically. Analysis of variance is carried out to validate the model and for determining the most significant parameter.

Findings
The feed rate is the cutting parameter which has greater influence on delamination (88.39 per cent), and cutting speed is the cutting parameter which has greater influence on surface roughness (53.42 per cent) for hybrid GFRP composite materials. Both surface roughness and delamination increase as feed rate increases, which means that the composite damage is larger for higher feed rates.

Originality/value
Effect of milling of hybrid GFRP composite on delamination and surface roughness with various helix angles of solid carbide end mill has not been analysed yet using RSM.
Investigation of flexural properties of hollow glass microsphere filled resin-matrix composites
Authors: Qiao Yingjie , Wang Xiaodong , Zhang Xiaohong , Xing Zhipeng 
Published: December 2016

Purpose
The purpose of this paper is to investigate the preparation and the flexural property of hollow glass microspheres (HGMs) filled resin-matrix composites, which have been widely applied in deep-sea fields.

Design/methodology/approach
The composites with different contents of HGMs from 47 to 57 Wt.% were studied. The voids in syntactic foams and their flexural properties were investigated.

Findings
The results showed that the voids quantity increased because of the increment of HGM content, whereas the exural strength and the exural modulus decreased. The fracture mechanism of the composites was also investigated by scanning electron microscope, which indicated that the composites failed by the crack extending through the microspheres.

Research limitations/implications
The advantages of HGMs with similar hollow spheres will be further investigated in a future research.

Practical implications
Results demonstrated that the properties of the composite might be tailored for specific application conditions by changing the HGM volume fraction.

Originality/value
The HGM filled resin-matrix composite materials have their unique properties and significant application potential. In this work, the resin-HGM composites were synthesized by mechanically mixing defined quantities of HGMs into epoxy resin, by which a kind of syntactic foams with good flexural properties could be obtained.
Local industry technological capability development using outsourcing opportunities
Authors: Gewe Ameha Mulugeta , Abebe Birhanu Beshah , Azene Daniel Kitaw , Bayu Fitsum Getachew 
Published: December 2016

Purpose
Technological outsourcing requires possessing the technological capability level by enterprises taking the outsourced activity and further mandates build-up capabilities. Small and medium enterprises (SMEs) in developing nations such as Ethiopia are usually equipped with low level of technological capability and could benefit from government-supported or government-initiated outsourcing networks. The current study aims to preliminarily assess performance of outsourcing initiative taken by the Hibret Manufacturing and Machine Building Industry, a subsidiary of a national corporation, in developing technological capability of SMEs in Ethiopia.

Design/methodology/approach
The study used a qualitative research approach through interviews with the parent company officials and owners of SMEs and site visit to these SMEs. Findings are organized in a way to draw lessons to be learned from technological outsourcing examined.

Findings
Technological learning, acquisition of new technologies, market access and process innovation are few capabilities achieved by the involved SMEs. To facilitate and harness these opportunities and further assist in policy ratification, a conceptual framework has been presented and elaborated.

Research limitations/implications
Further investigation into outsourcing procedure and biases are expected to shed further light onto the outsourcing initiative by the parent company. This study drew results from investigation of the SMEs involved. Additional investigation of other SMEs is expected to reveal additional insights.

Originality/value
There is a dearth of literature focusing on exploration of technological outsourcing in low-income developing countries, such as Ethiopia, to build SMEs’ technological capabilities. This research presents insightful contribution to strategic outsourcing to build local technological capability in developing economies.
Do grazing intensity and herbivore type affect soil health? Insights from a semi‐arid productivity gradient
Authors: Eldridge David J. , Delgado‐Baquerizo Manuel , Travers Samantha K. , Val James , Oliver Ian 
Published: December 2016

Summary

Grazing is one of the most widespread forms of intensive management on Earth and is linked to reductions in soil health. However, little is known about the relative influence of herbivore type, herbivore intensity and site productivity on soil health. This lack of knowledge reduces our capacity to manage landscapes where grazing is a major land use.

We used structural equation modelling to assess the effects of recent (cattle, sheep, goats, kangaroos and rabbit dung) and historic (cattle, sheep/goat livestock tracks) herbivore activity on soil health at 451 sites across 0·5 M km2 of eastern Australia. We assessed the direct and indirect effects of increasing herbivore intensity, using dung and livestock tracks, on 15 morphological, physical and chemical attributes that are indicative of soil health, and we used these attributes to derive three indices representing the capacity of the soil to maintain its structural integrity (stability), cycle nutrients (nutrients) and maintain water flow (infiltration).

Grazing had negative effects on the three soil health indices, but these effects varied with productivity. Grazing intensity was associated with strong reductions in the stability and nutrient indices under low productivity, but these effects diminished with increasing productivity. Herbivore effects on individual attributes varied in relation to productivity level and were strongly herbivore specific, with most due to cattle grazing, and to a lesser extent, sheep, goats and rabbits. Few effects due to kangaroos or historic grazing by livestock were observed.

Synthesis and applications. Our study shows that livestock and rabbits degrade soil health through grazing, and its effects are strongest under low or moderate productivity; however, kangaroo effects are benign. Our findings support calls for resource management agencies to consider site productivity, as well as herbivore type and intensity, when developing strategies to manage grazing by livestock, and feral and native herbivores.
Mycobacterium ulcerans toxin, mycolactone may enhance host‐seeking and oviposition behaviour by Aedes aegypti (L.) (Diptera: Culicidae)
Authors: Sanders M. L. , Jordan H. R. , Serewis‐Pond C. , Zheng L. , Benbow M. E. , Small P. L. , Tomberlin J. K. 
Published: December 2016

SummaryThe ecological functions of many toxins continue to remain unknown for those produced by environmental pathogens. Mycobacterium ulcerans, the causative agent of the neglected tropical disease, Buruli ulcer, produces a cytotoxic macrolide, mycolactone, whose function(s) in the environment remains elusive. Through a series of dual‐choice behaviour assays, they show that mycolactone may be an interkingdom cue for the yellow fever mosquito, Aedes aegypti, seeking blood‐meals as well as oviposition sites. Results provide novel insight into the evolution between bacteria and potential vectors. While further studies are needed to determine if mycolactone is an actual signal rather than simply a cue, this discovery could serve as a model for determining roles for toxins produced by other environmental pathogens and provide opportunities for developing novel strategies for disease prevention. The relationship between M. ulcerans, mycolactone, and Ae. aegypti further suggests there could be an amplification effect for the spread of pathogens responsible for other diseases, such as yellow fever and dengue.
Informativeness of NGS Analysis for Vaginal Fluid Identification
Authors: Giampaoli Saverio , DeVittori Elisabetta , Valeriani Federica , Berti Andrea , Romano Spica Vincenzo 
Published: December 2016

AbstractThe identification of vaginal fluids in forensic examinations plays an important role in crime scene reconstruction. Molecular detection of vaginal bacterial communities can lead to the correct discrimination of body fluids. These kinds of studies can be performed through multiplex real‐time PCR using primers for a specific selection of bacteria. The availability of next‐generation sequencing (NGS) protocols provided for the extension of the analysis to evaluate the prokaryotes present in specimens. In this study, DNA was extracted from 18 samples (vaginal, oral, fecal, yoghurt) and analyzed by real‐time PCR and NGS. The comparison between the two approaches has demonstrated that the information developed through NGS can augment the more conventional real‐time PCR detection of a few key bacterial species to provide a more probative result and the correct identification of vaginal fluid from samples that are more forensically challenged.