bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: SYNTHESIS OF NEW BILADIENE‐A,C DERIVATIVES AND THEIR CYCLIZATION TO UROPORPHYRIN III, 12‐DECARBOXYUROPORPHYRIN III AND PHYRIAPORPHYRIN III METHYL ESTERS
Authors: ENGEL J. , GOSSAUER A. 
Published: March 2016

AbstractMit Hilfe herkömmlicher Methoden werden zahlreiche Biladien‐"a,c‐Derivate dargestellt, deren Substitutionsmuster denjenigen des vom biologischen Standpunkt aus interessanten Uroporphyrins III (Ia), 12‐Descarboxyuroporphyrins III (Ib) bzw. Phyriaporphyrins III (Ic) entsprechen.
ChemInform Abstract: SYNTHESIS OF COVALENTLY LINKED PORPHYRIN DIMERS AND TRIMERS
Authors: ANTON J. A. , KWONG J. , LOACH P. A. 
Published: March 2016

AbstractIn der Porphyrin‐ Reihe dienen der Tetracarbonsäureester (I) sowie der Monoester (III) als Ausgangsmaterial.
ChemInform Abstract: METAL‐ASSISTED TERPENOID SYNTHESIS II. CATALYTIC CONVERSION OF ISOPRENE INTO FARNESENE AND ITS ISOMER, 2,6‐DIMETHYL‐10‐METHYLENE‐1,6‐TRANS‐11‐DODECATRIENE
Authors: AKUTAGAWA S. , TAKETOMI T. , OTSUKA S. 
Published: March 2016

AbstractIsopren (I) trimerisiert über Nickel‐Katalysatoren zu dem Dimethylmethylen‐dodecatrien (II) und zu β‐trans‐Farnesen (III).
ChemInform Abstract: A FACILE APPROACH TO AN (OPTICALLY ACTIVE TETRACYCLIC INTERMEDIATE) FOR THE SYNTHESIS OF 6‐METHYL‐19‐NORSTEROIDS
Authors: PANDIT U. K. , BIERAEUGEL H. 
Published: March 2016

AbstractDie asymmetrische Synthese von (‐)‐(13S,17S)‐(Vc), einem zentralen Zwischenprodukt, das für die im Titel erwähnte Klasse der Steroide erforderlich ist, wird beschrieben.
ChemInform Abstract: INSECT MOULTING HORMONES‐ THE SYNTHESIS OF ECDYSONE ANALOGUES FROM A BILE ACID
Authors: KINNEAR J. F. , MARTIN M.‐D. , HORN D. H. S. , MIDDLETON E. J. , WILKIE J. S. , GALBRAITH M. N. , WILLING R. I. 
Published: March 2016

AbstractDie Analogen (IVb), (VIIIc) bzw. (IVd) des Insektenhäutungshormons Ecdyson werden ausgehend von den Cholestan‐Derivaten (Ia), (V) bzw. (Ia) nach angegebenem Schema synthetisiert.
ChemInform Abstract: MICROBIOLOGICAL HYDROXYLATION. PART XXII. HYDROXYLATION OF 3,20‐, 7,20‐, AND 11,20‐DIOXYGENATED 5α‐PREGNANES
Authors: JONES E. R. H. , MEAKINS G. D. , MINERS J. O. , MIRRINGTON R. N. , WILKINS A. L. 
Published: March 2016

AbstractDie sauerstoffbifunktionellen Pregnanone (I)‐(III) werden der mikrobiologischen Hydroxylierung mit Calonectria decora (C.d.), Daedalea rufescens (D.r.), Rhizopus nigricans (R.n.), Rhizopus arrhizus und/oder Rhizopus circinans unterworfen.
ChemInform Abstract: HETEROCYCLIC STEROIDS. PART II. SYNTHESIS OF (.+‐.)‐8‐HYDROXY‐3‐METHOXY‐11‐AZA‐18‐NORESTRA‐1,3,5(10),9(11)‐TETRAEN‐17‐ONE AND RELATED COMPOUNDS
Authors: NASIPURI D. , GHOSH S. K. 
Published: March 2016

AbstractAusgehend von der Ketosäure (I) wird nach bekannten Verfahren über die Säure (II) das Keton (III) dargestellt, welches über das Furfurylidenderivat das Cyclopenten (IVa) liefert.
ChemInform Abstract: GLUCOPYRANOSE ANALOG OF 4‐CARBOXY‐5‐AMINOIMIDAZOLE RIBOTIDE
Authors: ALENIN V. V. , DOMKIN V. D. 
Published: March 2016

AbstractBei der Umsetzung der Verbindungen (I) und (II) beobachtet man eine nichtübliche stereospezifische Reaktion.
ChemInform Abstract: SYNTHESIS OF CERTAIN METABOLITES AND ANALOGS OF VITAMIN B6 AND THEIR RING‐CHAIN TAUTOMERISM
Authors: PAUL B. , KORYTNYK W. 
Published: March 2016

AbstractAus Pyridoxol (Ia) und Pyridoxal (IIIa) entstehen die Benzyläther (Ib) bzw. (IIIb), die zum Lacton (II) oxidiert werden.
ChemInform Abstract: UNUSUAL HYDROGEN BONDS. A NEUTRON DIFFRACTION STUDY OF THE HYDROGEN DINITRATE ION, (O2NO.CNTDOT.H.CNTDOT.ONO2)‐, IN CESIUM HYDROGEN DINITRATE
Authors: ROZIERE J. , ROZIERE‐BORIES M.‐T. , WILLIAMS J. M. 
Published: March 2016

AbstractDie Kristallstruktur der Titelverbindung wird aus 3dimensionalen Einkristall‐Neutronenbeugungswerten bestimmt (rhombisch, Raumgruppe Fddd, Z=8).
ChemInform Abstract: REPEATED REMOVAL OF THIN LAYERS OF SILICON BY ANODIC OXIDATION
Authors: BARBER H. D. , LO H. B. , JONES J. E. 
Published: March 2016

AbstractEs wird eine billige und einfache Schichttrennungsmethode (Anodisierung und anschließendes Ätzen) beschrieben, die, kombiniert mit Schichtwiderstandsmessungen, zur Bestimmung der Verunreinigungsprofile in Si geeignet ist.
ChemInform Abstract: INORGANIC POLYHEDRON COMPOUNDS, III. ZINTL′S ′POLYANIONIC SALTS′‐ PREPARATION N AND PROPERTIES OF THE CRYSTALLINE COMPOUNDS (NA4.7EN)SN9, (NA4.5EN)GE9, AND (NA3.4EN)SB7 AND OF THEIR SOLUTIONS. THE CRYSTAL STRUCTURE OF (NA4.7EN)SN9
Authors: DIEHL L. , KHODADADEH K. , KUMMER D. , STRAEHLE J. 
Published: March 2016

Abstract5 en]Ge9 und [Na3°C 4 en]Sb7 und ihrer Lösungen.
ChemInform Abstract: TAUTOMERISM IN CYTOSINE AND 3‐METHYLCYTOSINE. A THERMODYNAMIC AND KINETIC STUDY
Authors: DREYFUS M. , BENSAUDE O. , DODIN G. , DUBOIS J. E. 
Published: March 2016

AbstractWährend das Cytosin in Wasser hauptsächlich die Form (I) "bildet und sich nur geringfügig nach (II) tautomerisiert, liegt das Methylderivat (III) im Gleichgewicht mit seinem Imintautomeren (IV) vor.
ChemInform Abstract: BEHAVIOR OF NITRILE OXIDES TOWARDS NUCLEOPHILES. PART IV. HETEROMACROCYCLES FROM ACETONITRILE OXIDE
Authors: BRANDI A. , DE SARLO F. , GUARNA A. 
Published: March 2016

AbstractIn alkoholischer Lösung bildet Acetonitriloxid (I) mit Trime‐ thylamin im mittleren Konzentrationsbereich ein Hexameres, für das die Struktur (II) abgeleitet wird.
ChemInform Abstract: ISOMERIZATION OF α‐OXIDES ON A LITHIUM PHOSPHATE CATALYST. III. ISOMERIZATION OF 3,3‐DIMETHYL‐1,2‐EPOXYBUTANE
Authors: SREDNEV S. S. , KRYUKOV S. I. , FARBEROV M. I. 
Published: March 2016

AbstractDie Isomerisierung der Titelverbindung (I) liefert unter Skelettumlagerung den ungesättigten Alkohol (II) (Ausbeuteangabe fehlt), daneben Carbonylverbindungen sowie als Zerfallsprodukte des Alkohols (II) das Methylbuten (III) und Formaldehyd (IV).
ChemInform Abstract: THE PHOTOLYSIS AND THERMOLYSIS OF 3‐(DIPHENYLHYDROXYMETHYL)‐4‐(DIPHENYLMETHYLENE)‐2‐CYCLOBUTENE‐1‐ONE AND ITS 2‐BROMO DERIVATIVE
Authors: TODA F. , TODO E. 
Published: March 2016

AbstractDas Cyclobutenon (II) bildet bei seiner Photolyse in Methanol das Lacton (I), in Benzol dagegen ebenso wie bei seiner Thermolyse in o‐Xylol das gesättigte Derivat (III).
ChemInform Abstract: RADIATION INDUCED DECHLORINATION OF 1,2‐DICHLOROETHANE AND DETERMINATION OF ARRHENIUS PARAMETERS FOR HYDROGEN ATOM ABSTRACTION FROM CHLOROETHANES BY THE CYCLOHEXYL RADICAL
Authors: KATZ M. G. , BARUCH G. , RAJBENBACH L. A. 
Published: March 2016

AbstractBei der Radiolyse einer Lösung von 1,2‐Dichlor‐äthan in Cyclohexan werden durch radiolytisch gebildete Cyclohexylradikale unter Abspaltung von C1 bzw. H Chloräthyl‐ und 1,2‐Dichloräthyl‐Radikale erzeugt, die weiter hauptsächlich zu chlorierten Äthanen, Chlorcyclohexan und β‐Chloräthylcyclohexan reagieren.
ChemInform Abstract: STABLE NITROXIDE RADICALS FROM 2‐SUBSTITUTED QUINOLINE‐N‐OXIDES WITH ORGANOMETALLIC COMPOUNDS
Authors: BERTI C. , COLONNA M. , GRECI L. , MARCHETTI L. 
Published: March 2016

AbstractDie Reaktion des Chinolinoxids (Ia) mit der Grignardverbindung (IIa) in THF ergibt das Nitroxidradikal (IVa) sowie wenig Chinolin (V).
ChemInform Abstract: POLAR RADICALS. 9. KINETICS AND MECHANISM OF THE VAPOR‐PHASE BROMINATION OF 1‐BROMOBUTANE
Authors: TANNER D. D. , KOSUGI Y. , ARHART R. , WADA N. , PACE T. , RUO T. 
Published: March 2016

AbstractDie Photoreaktion der Titelverbindung (I) mit Brom im Verhältnis 5:1 ergibt hauptsächlich die Produkte (II)‐(IV).
ChemInform Abstract: 2‐ALKOXY‐, 2‐ARYLOXY‐, AND 2‐ACYLOXYCYCLOHEXANONES. SYNTHESIS AND STUDY OF THEIR CONFORMATIONAL EQUILIBRIUMS
Authors: CANTACUZENE D. , TORDEUX M. 
Published: March 2016

AbstractAryloxycyclohexanone wie z.B. (III) werden aus den Chloriden (I) und den Phenolaten (II) dargestellt.
ChemInform Abstract: PREPARATION OF CYCLONONA‐1,2,5‐TRIENE, CYCLONONA‐1,2,5,7‐TETRAENE AND CYCLODECA‐1,2,5,6‐TETRAENE
Authors: BAIRD M. S. , REESE C. B. 
Published: March 2016

AbstractDehydrobromierung des S‐Brom‐cyclooctens (I) liefert Cyclooctadien‐(1,4) (II) im Gemisch mit etwas Cyclooctadien‐(1,5).
ChemInform Abstract: REMOVAL OF SULFUR GROUPS FROM MOLECULES BY COPPER(I). PREPARATION OF SULFUR‐SUBSTITUTED 1,3‐DIENES FOR THE DIELS‐ALDER REACTION
Authors: COHEN T. , MURA A. J. , SHULL D. W. , FOGEL E. R. , RUFFNER R. J. , FALCK J. R. 
Published: March 2016

AbstractCrotonaldehyd (I) und Thiophenol geben das Thioäther‐dithioacetal (II), das in Gegenwart von Cu‐Pulver zum Phenylthio‐butadien (III) eliminiert.
ChemInform Abstract: CATALYTIC REARRANGEMENT OF O,S‐DIALKYL DITHIOCARBONATES TO S,S‐DIALKYL DITHIOCARBONATES. II. THE EFFECTS OF STRUCTURE OF O,S‐DIALKYL DITHIOCARBONATES, CATALYSTS AND SOLVENTS
Authors: KAWATA T. , HARANO K. , TAGUCHI T. 
Published: March 2016

AbstractAus Carbinolen (I) werden mit Alkalimetall, Schwefelkohlenstoff und Methyljodid die Xanthogenate (II) hergestellt, die katalytisch zu den Thioloestern (III) umgelagert und dann zu (IV) verseift werden.
ChemInform Abstract: MECHANISM OF THERMAL DECOMPOSITION OF DIAZIRINE. EVIDENCE FOR DIAZOMETHANE INTERMEDIATE
Authors: JENNINGS B. M. , LIU M. T. H. 
Published: March 2016

AbstractDas aus Valerophenon nach Literaturangaben dargestellte Diazirin (I) (40% Gesamtausbeute) zersetzt sich thermisch zu den l‐Phenyl‐pentenen (III) im cis‐/trans‐Verhältnis 1 : 5. Die Zersetzung verläuft über das isolierbare und erstaunlieh stabile Diazoalkan (II), das mit Essigsäure zu [l‐Phenyl‐pentyl‐(l)]‐acetat reagiert.
ChemInform Abstract: THE STEREOSPECIFIC SYNTHESIS OF α‐METHYLENE‐Γ‐BUTYROLACTONES OF TRANS‐1,3‐DIHYDROXYCYCLOALKANES
Authors: MARINO J. P. , FARINA J. S. 
Published: March 2016

AbstractReaktionen zwischen Cycloalkenon‐epoxiden und den Organo‐ Kupferverbindungen (I)‐(III) werden systematisch untersucht.
ChemInform Abstract: THERMAL REARRANGEMENT OF 2‐OXABICYCLO(2.2.2)OCT‐5‐ENO‐3‐CARBOXYLIC ACIDS
Authors: ACHMATOWICZ O. JUN. , JURCZAK J. , PYREK J. S. 
Published: March 2016

AbstractAus Diäthylmesoxalat (I) und Cyclohexadien (II) entsteht im Bombenrohr durch Diels‐Alder‐Reaktion der Diester (III), der mit LiAlH4 zum Diol reduziert werden kann (85% Ausbeute), katalytisch zum Dihydro‐ (IV) und Tetrahydro‐Derivat (V) hydriert und mit methanolischem KOH zur Disäure (IIIb) hydrolysiert wird.
ChemInform Abstract: THE REACTION OF ENAMINES WITH β‐KETO ESTERS‐ A ROUTE TO Γ‐PYRONES
Authors: MONSON R. S. 
Published: March 2016

AbstractAus den β‐Ketoestern (I) erhält man bei der Umsetzung mit Enaminen (II) die 7‐Pyrone‐ (III) in mäßigen Ausbeuten neben den Amiden (IV).
ChemInform Abstract: 1,8‐NAPHTHYRIDINES. PART III. SYNTHESIS OF SOME 6‐SUBSTITUTED‐1,8‐NAPHTHYRIDIN‐2(1H)‐ONES
Authors: EICHLER E. , ROONEY C. S. , WILLIAMS H. W. R. 
Published: March 2016

AbstractDie Kondensation von 2,6‐Diamino‐pyridin (II) mit Malondialdehyden (I) führt zu den Kondensationsprodukten (III), die zu (IV) hydrolysiert werden können.
ChemInform Abstract: A SYMMETRICAL DIAZADITWISTANE. 2,9‐DICYANO‐5,11‐DIMETHYL‐5,11‐DIAZATETRACYCLO(6.2.2.02,7.04,9)DODECANE
Authors: TEN BROEKE J. , DOUGLAS A. W. , GRABOWSKI E. J. J. 
Published: March 2016

AbstractAus dem nach früheren Verfahren zugänglichen Dicyano‐dimethyl‐diazatetracyclododecan (I) erhält man über Platin das Hydrierungsprodukt (II), das beim Erhitzen zum Diazaditwistan (III) führt.
ChemInform Abstract: ANTIBACTERIAL COMPOUNDS IN THE DEHYDRO‐N‐MANNICH BASE SERIES
Authors: KREUTZBERGER A. , TESCH U.‐H. , GUERSOY A. 
Published: March 2016

AbstractDie Darstellung des Cumarinderivats (IV) erfolgt wahrscheinlich über die Zwischenstufen (V) und (VI).
ChemInform Abstract: REACTION OF N,N′‐METHYLENEDILACTAMS FROM CYCLIC IMINO CHLORIDES AND DIMETHYL SULFOXIDE
Authors: HABECK D. , HOULIHAN W. J. 
Published: March 2016

AbstractAus dem Diazepindion (I) erhält man mit Phosgen die Dichlorverbindung (II), die zum Imidchlorid (III) dehydrochloriert wird.
ChemInform Abstract: MECHANISM OF THE FORMATION AND REARRANGEMENT OF SPIROPHOSPHORANES. VIII. REACTIONS OF SPIROPHOSPHORANES CONTAINING A PHOSPHORUS‐HYDROGEN BOND WITH REACTIVE ELECTROPHILES
Authors: LAURENCO C. , BURGADA R. 
Published: March 2016

AbstractDie Verbindung (I) und analoge methylsubstituierte Spirophosphorane reagieren mit Iminen und Aminoverbindungen zu den Derivaten (II).
ChemInform Abstract: THIOUREA ADDUCTS OF DIMETHYLHALOARSINES. CATIONIC TRIVALENT ARSENIC
Authors: JAVORA P. H. , MEYERS E. A. , ZINGARO R. A. 
Published: March 2016

AbstractDie Reaktion von Dimethylarsenchlorid oder ‐bromid mit Thioharnstoff in aprotischen Lösungsmitteln liefert 1:1‐ und 1:2‐Verbindungen (I) und (II).
ChemInform Abstract: ALKYL COMPLEXES OF SCANDIUM(III), TITANIUM(III) AND VANADIUM(III) DERIVED FROM PHOSPHORUS YLIDE ANIONS
Authors: MANZER L. E. 
Published: March 2016

AbstractDie durch Umsetzung von Butyl‐Li mit entsprechenden Phosphoniumjodiden in Äther dargestellten Li‐Salze (II) der P‐Ylid‐Anionen setzen sich mit den Übergangsmetallkomplexen (I) zu den Alkylkomplexen (III) um (Ausbeutenangabe zum Teil in Gramm).
ChemInform Abstract: STEREOSPECIFIC INCORPORATION OF CARBON‐13‐LABELED CARBON MONOXIDE INTO OLEFINIC SUBSTITUTED METAL CARBONYL COMPOUNDS
Authors: DARENSBOURG D. J. J. , SALZER A. 
Published: March 2016

AbstractDer Trien‐Molybdänkomplex (I) reagiert mit 13CO in Kohlenwasser= Stoff‐Lösungen bei Raumtemperatur zu der Tetracarbonyl‐Verbindung (II).
ChemInform Abstract: ORGANOMETALLIC CHEMISTRY OF THE CARBON‐NITROGEN DOUBLE BOND. 1. NICKEL COMPLEXES PREPARED FROM IMINIUM CATIONS AND THE X‐RAY STRUCTURE OF (((C6H5)3P)NI(CH2N(CH3)2)CL)
Authors: SEPELAK D. J. , PIERPONT C. G. , BAREFIELD E. K. , BUDZ J. T. , POFFENBERGER C. A. 
Published: March 2016

AbstractIminiumsalze (I) reagieren mit Ni(O)‐Komplexen (II) zu den Verbindungen (III), in denen das Iminiumion ′lt‐gebunden in trigonaler Koordination vorliegt.
ChemInform Abstract: CONCERNING THE THERMOCHROMIC MECHANISM OF COPPER(II) AND NICKEL(II) COMPLEXES OF N,N‐DIETHYLETHYLENEDIAMINE
Authors: FERRARO J. R. , BASILE L. J. , GARCIA‐INEGUEZ L. R. , PAOLETTI P. , FABBRIZZI L. 
Published: March 2016

AbstractAnhand von IR‐ und Elektronenspektren wird der T.hermochromie‐Mechanismus der Komplexe (I) erörtert, wobei Druck‐ und Temperaturuntersuchungen eingeschlossen werden.
ChemInform Abstract: METAL COMPLEXES OF SULFUR‐NITROGEN CHELATING AGENTS. V. 2‐N‐ETHYLAMINOCYCLOPENTENE‐1‐DITHIOCARBOXYLIC ACID COMPLEXES OF NICKEL(II), PALLADIUM(II), PLATINUM(II), COBALT(II), COBALT(III), AND COPPER(I)
Authors: NAG K. , JOARDAR D. S. 
Published: March 2016

AbstractDas Ammoniumsalz des Liganden reagiert mit den Tetrachlorometallaten von Pd und Pt, Ni‐chlorid bzw. Co‐nitrat zu den 2:1‐Komplexen (I) bzw. (IIa).
ChemInform Abstract: SYNTHESIS OF SESQUITERPENE ANTITUMOR LACTONES. 6. CIS‐8A‐VINYLOCTAHYDRO‐3H‐2‐BENZOPYRAN‐3,7‐DIONE, A PRECURSOR TO VERNOLEPIN
Authors: WEGE P. M. , CLARK R. D. , HEATHCOCK C. H. 
Published: March 2016

AbstractAus den 3‐Alkoxy‐cyclohexenonen (I) werden die Substitutionsprodukte (III) hergestellt.
ChemInform Abstract: SYNTHESIS AND CONFORMATIONAL STABILITIES OF 11‐OXO‐9α‐ AND 9β‐ESTRADIOL 3‐BENZYL ETHER
Authors: LIANG C. D. , BARAN J. S. , ALLINGER N. L. , YUH Y. 
Published: March 2016

AbstractDas aus dem Diacetat (I) zugängliche Epoxid (II) wird mit KOH zu dem 9ß‐Dihydroxyketon (IIIa) hydrolysiert, dessen 3‐Benzyläther (IIIb) beim Umsetzen mit NaH/Benzol zu dem 9oz‐Isomeren (IIIc) epirnerisiert.
Two‐Year Safety and Efficacy of Biodegradable Polymer Drug‐Eluting Stent Versus Second‐Generation Durable Polymer Drug‐Eluting Stent in Patients With Acute Myocardial Infarction: Data from the Korea Acute Myocardial Infarction Registry (KAMIR)
Authors: Hur Seung‐Ho , Kim In‐Cheol , Won Ki‐Bum , Cho Yun‐Kyeong , Yoon Hyuck‐Jun , Nam Chang‐Wook , Kim Kwon‐Bae , Kim Min‐Seok , Park Jincheol , Rha Seung‐Woon , Chae Shung‐Chull , Kim Young‐Jo , Kim Chong‐Jin , Cho Myeong‐Chan , Jeong Myung‐Ho , Ahn Young‐Keun , Kim Hyo‐Soo , Ahn Tae‐Hoon , Seung Ki‐Bae , Jang Yangsoo , Yoon Jung‐Han , Seong In‐Whan , Hong Taek‐Jong , Bae Jang‐Ho , Park Seung‐Jung ,   for the KAMIR (Korea Acute Myocardial Infarction Registry) Investigators
Published: March 2016

ABSTRACTBackgroundDespite improved long‐term safety of biodegradable polymer (BP) drug‐eluting stents (DES) compared to first‐generation durable polymer (DP) DES, data on the safety and efficacy of BP‐DES compared with second‐generation (2G) DP‐DES in patients with acute myocardial infarction (AMI) are limited.HypothesisTo evaluate the safety and efficacy of BP‐DES compared with 2G‐DP‐DES in the higher stent thrombosis (ST) risk setting of AMI.MethodsA total of 3359 AMI patients who received either BP‐DES (n = 261) or 2G‐DP‐DES (n = 3098) were included from the Korea Acute Myocardial Infarction Registry (KAMIR). Differences in baseline clinical and angiographic characteristics were adjusted using a 1:5 propensity score matching analysis (n = 261 for BP‐DES and n = 1305 for 2G‐DP‐DES). The primary outcome was the incidence of major adverse cardiac events (MACE) including all‐cause death, recurrent myocardial infarction (re‐MI), and target vessel revascularization (TVR). The rate of definite or probable ST was also investigated.ResultsIn adjusted analysis, there was no significant difference between the 2 groups in baseline clinical and angiographic characteristics; 2‐year MACE (10.7% and 9.9% in the BP‐DES group and 2G‐DP‐DES group, respectively, P = 0.679); ST incidence (0.8% vs 0.9%, respectively, P = 1.0), and rates of all‐cause death, re‐MI, and TVR. By multivariate analysis, old age, diabetes mellitus, renal dysfunction, and left ventricular dysfunction were the independent predictors of MACE after BP‐DES or 2G‐DP‐DES implantation.ConclusionsBP‐DES and 2G‐DP‐DES appear to have comparable 2‐year safety and efficacy for the treatment of AMI. However, longer‐term follow‐up is needed.
Endothelial Dysfunction and Racial Disparities in Mortality and Adverse Cardiovascular Disease Outcomes
Authors: Erqou Sebhat , Kip Kevin E. , Mulukutla Suresh R. , Aiyer Aryan N. , Reis Steven E. 
Published: March 2016

AbstractBackgroundThe contribution of arterial endothelial dysfunction (ED) to increased cardiovascular disease (CVD) risk among Blacks is not known.HypothesisWe investigated whether peripheral arterial ED explains racial disparity in CVD events.MethodsData from the Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) study was used. Endothelial dysfunction was assessed by the Framingham reactive hyperemia index (fRHI), measured using pulse amplitude tonometry (PAT). Lower values of fRHI indicate more severe ED. The primary outcome of interest was combined CVD events and all‐cause mortality.Results1454 individuals (62% female, 40% Black, mean age 59 ± 8 years) had available data on fRHI (mean [SD]: 0.74 [0.46]). Over a mean follow‐up period of 8.0 ± 2.4 years (11,186 person‐years), 116 events were observed. Black race, male sex, smoking, diabetes, blood pressure, triglycerides, C‐reactive protein, and interleukin‐6 were inversely correlated with fRHI in univariate models. In an unadjusted Cox regression model, fRHI was associated with 20% lower risk of the primary outcome events (hazard ratio [HR] per 1‐SD higher fRHI: 0.80, 95% confidence interval [CI]: 0.66‐0.97). However, this association was no longer significant after adjustment for CVD risk factors (HR: 0.90, 95% CI: 0.74‐1.11). In an age‐ and sex‐adjusted model, Blacks had 1.68 (95% CI: 1.16‐2.43) higher risk of primary outcome compared with Whites. This association was not significantly attenuated by addition of fRHI to the multivariable models.ConclusionBlack race is associated with increased risk of CVD events and mortality independent of its associations with ED, as measured by PAT.
Large‐Deviation Principle for Interacting Brownian Motions
Authors: Seo Insuk 
Published: March 2016

AbstractWe prove the large‐deviation principle for the empirical process in a system of locally interacting Brownian motions in the nonequilibrium. Such a phenomenon has been proven only for two lattice systems: the symmetric simple exclusion process and the zero‐range process. Therefore, we have achieved the third result in this context and moreover the first result for the diffusion‐type interacting particle system.© 2016 Wiley Periodicals, Inc.
Molecular and Interfacial Calculations of Iron(II) Light Harvesters
Authors: Fredin Lisa A. , Wärnmark Kenneth , Sundström Villy , Persson Petter 
Published: March 2016

AbstractInvited for this month′s cover is Petter Persson and co‐workers at Lund University. The image illustrates recent progress in the development and understanding of earth‐abundant iron complexes for solar energy applications. The Full Paper itself is available at 10.1002/cssc.201600062.
Rapid Access to Benzofuran‐Based Natural Products through a Concise Synthetic Strategy
Authors: Rao Maddali L. N. , Murty Venneti N. 
Published: March 2016

AbstractA concise strategy is described for the synthesis of ailanthoidol (1), egonol (2), homoegonol (3), demethoxyegonol (4), demethoxyhomoegonol (5), and stemofuran A (6). This approach involves a Pd‐catalysed domino cyclization/coupling process using triarylbismuth reagents for the generation of the benzofuran core. Subsequent structural modifications then give the final targets. The high yielding synthesis of the recently isolated natural products egonol‐9(Z)‐12(Z)‐linoleate (2a), 7‐demethoxyegonol‐9(Z)‐12(Z)‐linoleate (4a), and 7‐demethoxy‐egonol‐9(Z)‐oleate (4b) are also reported.
Effects of pregabalin on the nociceptive, emotional and cognitive manifestations of neuropathic pain in mice
Authors: La Porta C. , Lara‐Mayorga I.M. , Negrete R. , Maldonado R. 
Published: March 2016

AbstractBackgroundPreclinical drug discovery for the treatment of chronic pain is at present challenged by the difficulty to study behaviours comparable to the complex human pain experience in animals. Several reports have demonstrated a frequent association of chronic pain in humans with affective disorders, such as anxiety and depression, and impaired cognitive functions, including memory and decision making, and motivation for goal‐directed behaviours. In this study, we validated different behavioural outcomes to measure the emotional and cognitive manifestations of neuropathic pain induced in mice by partial sciatic nerve ligation.MethodsIn these mice, we evaluated at different time points the nociceptive responses, the anxiety‐ and depressive‐like behaviours, the anhedonic state, object recognition memory and the operant responding maintained by food and the effects of the repeated administration of pregabalin on these manifestations.ResultsOur results demonstrated that the presence of allodynia and hyperalgesia in neuropathic pain mice was associated with increased anxiety‐ and depressive‐like behaviours, reduced memory functions, development of an anhedonic state and impaired motivation to obtain food in the operant task. Chronic pregabalin treatment improved the nociceptive, anxiety‐like and anhedonic responses, as well as the memory deficit, but did not modify the depressive‐like alterations and the decreased motivation in these mice.ConclusionsThese results indicate that some emotional manifestations of chronic pain do not necessarily resolve when pain is relieved and underline the relevance to evaluate multiple behavioural responses associated with chronic pain, including the affective‐motivational and cognitive behaviours, to increase the predictive value of preclinical drug discovery.What does this study add?

In this study, we have validated different behavioural outcomes allowing a reliable measurement of the emotional and cognitive manifestations of neuropathic pain induced in mice by partial sciatic nerve ligation.

These results underline the relevance to evaluate these multiple pain‐related alterations to improve the predictive value of preclinical drug discovery.