bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chiral ionic liquids with a (−)-menthol component as wood preservatives
Authors: Zabielska-Matejuk Jadwiga , Feder-Kubis Joanna , Stangierska Anna , Przybylski Piotr 
Published: May 2017

Abstract
Research has been conducted on the biotic activity of eight chiral ionic liquids (CILs) with a natural component in the form of (−)-menthol with the configuration (1R,2S,5R) against Basidiomycetes and Fungi imperfecti. Optically active imidazolium salts were tested as follows: several asymmetric 3-alkyl-1-[(1R,2S,5R)-(−)-menthoxymethyl]imidazolium chlorides with various alkyl substituents (from methyl to dodecyl) and one symmetric 1,3-bis[(1R,2S,5R)-(−)-menthoxymethyl]imidazolium chloride containing two (1R,2S,5R)-(−)-menthol substituents. Mycological tests were carried out with brown-rot and white-rot fungi, as well as with filamentous fungi, i.e. mold fungi and blue stain fungi. The new, optically active compounds demonstrated diverse effectiveness of fungicidal activity, which was dependent on the chemical structure of the functional groups. The natural (−)-menthol component, introduced as a substituent in ionic liquids, turned out to be an optically active compound with activity against wood-destroying fungi. (1R,2S,5R)-(−)-menthol was especially active against the fungi tested. The fungicidal value of imidazolium chloride with two (−)-menthol substituents against Coniophora puteana ranged from 1.8 to 2.9 kg m−3. The adsorption processes on Scots pine wood and resistance to water leaching were examined. The sorption properties of symmetric salts with two optical active (−)-menthol substituents fitted very well with the Freundlich adsorption model. Attenuated total reflection-infrared (ATR-IR) spectra confirmed that methylene groups of the aliphatic substituent, the ring of the heterocyclic imidazole, as well as the ether bridge of the natural (−)-menthol component were fixed in the structure of the impregnated pine wood (Pinus sylvestris L.). The positive results encourage further investigation of the potential application of novel functional CILs (Figure 1) for wood protection.
Evaluation of hepatic glycogen content, some haematological and biochemical parameters of alloxan-induced diabetic rats treated with combinations of glibenclamide and G. latifolium extract
Authors: Aba Patrick E. 
Published: May 2017

Abstract

Background
Diabetes is associated with both biochemical and haematological complications. Combination therapy has been advocated to mitigate some of these complications.

Aim
This study was designed to investigate the effects of glibenclamide and Gongronema latifolium (GL) on hepatic glycogen content and haemato-biochemical parameters.

Methods
Thirty male Wistar rats were assigned into five groups of six rats each. Groups 2–5 rats received intraperitoneally, 160 mg/kg of alloxan monohydrate while group 1 rats served as normal control. Groups 2–5 rats were respectively treated with 10 mL/kg distilled water (DW), 2 mg/kg glibenclamide, 200 mg/kg GL and 2 mg/kg glibenclamide and 200 mg/kg GL, while group 1 rats received 10 mL/kg DW. All treatments were per os daily for 21 days. Blood samples for investigation of haemato-biochemical (red blood cell [RBC], packed cell volume [PCV], haemoglobin concentration [Hb], blood urea nitrogen [BUN] and creatinine) parameters were collected on days 7, 14 and 21 post-treatment (PT), while the liver sample for hepatic glycogen determination was obtained on day 21 PT.

Results
Creatinine and BUN values of groups 3 and 4 rats were comparable to that of group 1 but were significantly (p<0.05) lower when compared with those of groups 2 and 5. There were significant (p<0.05) increases in the mean hepatic glycogen content, RBC, PCV, and Hb of group 4 rats when compared to those of group 2.

Conclusions
It was concluded that a combination of glibenclamide and G. latifolium in treatment of diabetic rats improved glycogen storage and demonstrated beneficial effects on haematology and kidney marker parameters.
TA-ABC: Two-Archive Artificial Bee Colony for Multi-objective Software Module Clustering Problem
Authors: Amarjeet  , Chhabra Jitender Kumar 
Published: May 2017

Abstract
Multi-objective software module clustering problem (M-SMCP) aims to automatically produce clustering solutions that optimize multiple conflicting clustering criteria simultaneously. Multi-objective evolutionary algorithms (MOEAs) have been a most appropriate alternate for solving M-SMCPs. Recently, it has been observed that the performance of MOEAs based on Pareto dominance selection technique degrades with multi-objective optimization problem having more than three objective functions. To alleviate this issue for M-SMCPs containing more than three objective functions, we propose a two-archive based artificial bee colony (TA-ABC) algorithm. For this contribution, a two-archive concept has been incorporated in the TA-ABC algorithm. Additionally, an improved indicator-based selection method is used instead of Pareto dominance selection technique. To validate the performance of TA-ABC, an empirical study is conducted with two well-known M-SMCPs, i.e. equal-size cluster approach and maximizing cluster approach, each containing five objective functions. The clustering result produced by TA-ABC is compared with existing genetic based two-archive algorithm (TAA) and non-dominated sorting genetic algorithm II (NSGA-II) over seven un-weighted and 10 weighted practical problems. The comparison results show that the proposed TA-ABC outperforms significantly TAA and NSGA-II in terms of modularization quality, coupling, cohesion, Pareto optimality, inverted generational distance, hypervolume, and spread performance metrics.
Effect of Bicyclol tablets on drug induced liver injuries after kidney transplantation
Authors: Shang Wenjun , Feng Yonghua , Li Jinfeng , Wang Xinzhou , Xie Hongchang , Feng Guiwen 
Published: May 2017

AbstractLiver injury is one of the most common complications in patients after kidney transplantation. Bicyclol tablets possess obvious anti-inflammatory and liver-protective functions. This study aimed to explore the clinical effect of preventive application of Bicyclol on drug induced liver injuries at an early stage after kidney transplantation.A total of 1600 patients who accepted kidney transplantations at our hospital from January 2009 to May 2015 were enrolled in this study, and divided into the prevention group (Bicyclol) and the control group (no hepatic protectors) based on whether or not hepatic protectors were regularly administered after the operation. The occurrence of liver injuries at an early stage after the operation and their influencing factors were analyzed.Total of 745 cases were included in the final analysis of which 82 developed liver injuries post-operation, with 22 in the prevention group (4.82%) as compared to 60 in the control group (20.76%) (P= 0.001). As compared to the control group, OR (95% CI) of the prevention group was 0.197 (0.116, 0.334) after revising HBsAg status, age and maintenance immunosuppression.Prophylactic application of Bicyclol as liver-protective treatment was a protective factor against drug induced liver injuries at an early stage after kidney transplantation.
The clinical characteristics of patients with chronic idiopathic anal pain
Authors: Mao Weiming , Liao Xiujun , Wu Wenjing , Yu Yanyan , Yang Guangen 
Published: May 2017

Abstract
The aim of this study was to investigate the clinical characteristics, treatment outcomes and psychological distress in patients with chronic idiopathic anal pain. The study was conducted on patients referred to Hangzhou Third Hospital for chronic anal pain from January, 2010 to December, 2014. Patient demographics, clinical history, anorectal physiology, and radiological imaging data were recorded for all patients. The treatment outcome was noted for patients treated and followed up for more than 6 month at the present unit. Ninety-six patients with mean age of 45.1 years (range, 17-82) were studied. Seventy-one patients (74.0%) had functional anorectal pain(FARP). The main complaints were dull, sharp, stabbing, or spasm pain. Among all patients, 34.3% reported that their pain radiated into other locations. Fifty-one patients (53.1%) had bowel dysfunction, while 28.1% patients had urinary dysfunction. The common factors associated with pain relief were day time, lying down and warm water baths; the factors that contributed to aggravated pain were night time, defecation or sitting. 92.7% (89/96) of patients reported symptoms of psychological disturbance. FARP patients exhibited increased depression than non-FARP patients(P<0.05). In addition, female patients were more likely to have depression than male patients (P<0.05). The overall pain treatment success rate was 55.2% (53/96). The pain treatment outcome was better in non-FARP patients than in FARP patients(χ2=3.85, P<0.05). Conclusively, chronic idiopathic anal pain is a complex clinical symptom, involving pelvic floor muscles, the nervous system, endocrine system, and the patients’ psychological conditions. Further research is needed to improve diagnosis and treatment for patients with chronic idiopathic anal pain.
The crystal structure of the Schiff base (E)-2,6-diisopropyl-N-(pyridin-3-yl-methylene)aniline, C18H22N2
Authors: Njogu Eric M. , Omondi Bernard , Nyamori Vincent O. 
Published: May 2017

Abstract
C18H22N2, monoclinic, P21/c (no. 14), a = 8.1226(5) Å, b = 17.4745(10) Å, c = 11.1822(6) Å, β = 102.549(2)°, V = 1549.27(15) Å3, Z = 4, R
gt(F) = 0.0397, wR
ref(F
2) = 0.1071, T = 100 K.
Crystal structure of 3-(4-methoxyphenyl)-1-(4-methylphenyl)prop-2-en-1-one, C17H16O2
Authors: Köysal Yavuz , Bülbül Hakan , Özdemir Funda , İlhan İlhan Özer , Dege Necmi 
Published: May 2017

Abstract
C17H16O2, monoclinic, P21/c (no. 14), a = 11.6963(12) Å, b = 11.1187(8) Å, c = 11.6902(10) Å, β = 115.545(7)°, V = 1371.7(2) Å3, Z = 4, R
gt(F) = 0.0350, wR
ref(F
2) = 0.0865, T = 293 K.
Crystal structure of catena-poly[di-(μ3-oxido-κ3
O:O:O)-tetraoxido-(μ2-5′-(pyrazin-2-yl)-1H,2′H-3,3′-bi(1,2,4-triazole)-κ2
N:N′)dimolybdenum(VI)], C8H6Mo2N8O6
Authors: Zhang Lei , Nie Cong-Kui , Zhao Dan 
Published: May 2017

Abstract
C8H6Mo2N8O6, triclinic, P1̅ (no. 2), a = 7.3053(7) Å, b = 8.7683(9) Å, c = 11.6150(12) Å, α = 87.578(2)°, β = 74.490(2)°, γ = 71.912(2)°, V = 680.80(12) Å3, Z = 2, R
gt(F) = 0.454, wR
ref(F
2) = 0.1100, T = 296 K.
Development and characterization of a formulation based covalent conjugation with polyacrylic acid and recombinant major surface antigen (SAG1) of Toxoplasma gondii
Authors: Cakir Koc Rabia , Budama Kilinc Yasemin 
Published: May 2017

Abstract

Introduction
Toxoplasmosis is a major disease caused by Toxoplasma gondii that infects approximately half the world’s population. The development of an effective vaccine would be extremely valuable for preventing disease. SAG1 is a major surface antigen of parasites and one of the most antigenic proteins of T. gondii. Developing highly antigenic and effective vaccine formulations using new generations of adjuvants and delivery systems is very important. Polyacrylic acid (PAA) is a polymer that increases the immunogenicity of an antigen to which it is covalently linked. The aim of this study was to develop a new formulation candidate with high stability and immunogenicity potential against toxoplasmosis via a covalent conjugation of PAA and the SAG1 protein.

Methods
PAA and SAG1 were covalently conjugated using a water-soluble carbodiimide crosslinker that activates carboxyl groups for spontaneous reaction with primary amines. To demonstrate conjugation of these molecules in size exclusion chromatography (SEC), fluorescence spectroscopy was used.

Results
For the first time, one of the most important surface antigens of T. gondii was conjugated to a PAA polymer, SEC and fluorescence spectra results.

Discussion and conclusion
The obtained SAG1-PAA conjugate can be used for vaccine development against T. gondii in future.
Hyper‐reactive cloned mice generated by direct nuclear transfer of antigen‐specific CD4+ T cells
Authors: Kaminuma Osamu , Katayama Kazufumi , Inoue Kimiko , Saeki Mayumi , Nishimura Tomoe , Kitamura Noriko , Shimo Yusuke , Tofukuji Soichi , Ishida Satoru , Ogonuki Narumi , Kamimura Satoshi , Oikawa Mami , Katoh Shigeki , Mori Akio , Shichijo Michitaka , Hiroi Takachika , Ogura Atsuo 
Published: May 2017

AbstractT‐cell receptor (TCR)‐transgenic mice have been employed for evaluating antigen‐response mechanisms, but their non‐endogenous TCR might induce immune response differently than the physiologically expressed TCR. Nuclear transfer cloning produces animals that retain the donor genotype in all tissues including germline and immune systems. Taking advantage of this feature, we generated cloned mice that carry endogenously rearranged TCR genes from antigen‐specific CD4+ T cells. We show that T cells of the cloned mice display distinct developmental pattern and antigen reactivity because of their endogenously pre‐rearranged TCRα (rTα) and TCRβ (rTβ) alleles. These alleles were transmitted to the offspring, allowing us to establish a set of mouse lines that show chronic‐type allergic phenotypes, that is, bronchial and nasal inflammation, upon local administrations of the corresponding antigens. Intriguingly, the existence of either rTα or rTβ is sufficient to induce in vivo hypersensitivity. These cloned mice expressing intrinsic promoter‐regulated antigen‐specific TCR are a unique animal model with allergic predisposition for investigating CD4+ T‐cell‐mediated pathogenesis and cellular commitment in immune diseases.
Assessment of Single Cell RNA-Seq Normalization Methods
Authors: Ding Bo , Zheng Lina , Wang Wei 
Published: May 2017

Abstract
We have assessed the performance of seven normalization methods for single cell RNA-seq using data generated from dilution of RNA samples. Our analyses showed that methods considering spike-in External RNA Control Consortium (ERCC) RNA molecules significantly outperformed those not considering ERCCs. This work provides a guidance of selecting normalization methods to remove technical noise in single cell RNA-seq data.
A Slowed Cell Cycle Stabilizes the Budding Yeast Genome
Authors: Vinton Peter J , Weinert Ted 
Published: May 2017

Abstract
During cell division, aberrant DNA structures are detected by regulators called checkpoints that slow division to allow error correction. In addition to checkpoint-induced delay, it is widely assumed, though rarely shown, that merely slowing the cell cycle might allow more time for error detection and correction, thus resulting in a more stable genome. Fidelity by a slowed cell cycle might be independent of checkpoints. Here we tested the hypothesis that a slowed cell cycle stabilizes the genome, independent of checkpoints, in the budding yeast Saccharomyces cerevisiae. We were led to this hypothesis when we identified a gene (ERV14, an ER cargo membrane protein) that when mutated, unexpectedly stabilized the genome, as measured by three different chromosome assays. After extensive studies of pathways rendered dysfunctional in erv14 mutant cells, we are led to the inference that no particular pathway is involved in stabilization, but rather the slowed cell cycle induced by erv14 stabilized the genome. We then demonstrated that, in genetic mutations and chemical treatments unrelated to ERV14, a slowed cell cycle indeed correlates with a more stable genome, even in checkpoint-proficient cells. Data suggest a delay in G2/M may commonly stabilize the genome. We conclude that chromosome errors are more rarely made or are more readily corrected when the cell cycle is slowed (even ∼15 min longer in an ∼100-min cell cycle). And, some chromosome errors may not signal checkpoint-mediated responses, or do not sufficiently signal to allow correction, and their correction benefits from this “time checkpoint.”
Safety Profile of Cough and Cold Medication Use in Pediatrics
Authors: Green Jody L. , Wang George Sam , Reynolds Kate M. , Banner William , Bond G. Randall , Kauffman Ralph E. , Palmer Robert B. , Paul Ian M. , Dart Richard C. 
Published: May 2017

BACKGROUND AND OBJECTIVES:
The safety of cough and cold medication (CCM) use in children has been questioned. We describe the safety profile of CCMs in children &lt;12 years of age from a multisystem surveillance program.

METHODS:
Cases with adverse events (AEs) after ingestion of at least 1 index CCM ingredient (brompheniramine, chlorpheniramine, dextromethorphan, diphenhydramine, doxylamine, guaifenesin, phenylephrine, and pseudoephedrine) in children &lt;12 years of age were collected from 5 data sources. An expert panel determined relatedness, dose, intent, and risk factors. Case characteristics and AEs are described.

RESULTS:
Of the 4202 cases reviewed, 3251 (77.4%) were determined to be at least potentially related to a CCM, with accidental unsupervised ingestions (67.1%) and medication errors (13.0%) the most common exposure types. Liquid (67.3%), pediatric (75.5%), and single-ingredient (77.5%) formulations were most commonly involved. AEs occurring in &gt;20% of all cases included tachycardia, somnolence, hallucinations, ataxia, mydriasis, and agitation. Twenty cases (0.6%) resulted in death; most were in children &lt;2 years of age (70.0%) and none involved a therapeutic dose. The overall reported AE rate was 0.573 cases per 1 million units (ie, tablets, gelatin capsules, or liquid equivalent) sold (95% confidence interval, 0.553–0.593) or 1 case per 1.75 million units.

CONCLUSIONS:
The rate of AEs associated with CCMs in children was low. Fatalities occurred even less frequently. No fatality involved a therapeutic dose. Accidental unsupervised ingestions were the most common exposure types and single-ingredient, pediatric liquid formulations were the most commonly reported products. These characteristics present an opportunity for targeted prevention efforts.
Herbal Medicines for Gastrointestinal Disorders in Children and Adolescents: A Systematic Review
Authors: Anheyer Dennis , Frawley Jane , Koch Anna Katharina , Lauche Romy , Langhorst Jost , Dobos Gustav , Cramer Holger 
Published: May 2017

CONTEXT:
Gastrointestinal disorders are common childhood complaints. Particular types of complementary and alternative medicine, such as herbal medicine, are commonly used among children. Research information on efficacy, safety, or dosage forms is still lacking.

OBJECTIVES:
To systematically summarize effectiveness and safety of different herbal treatment options for gastrointestinal disorders in children.

DATA SOURCES:
Medline/PubMed, Scopus, and the Cochrane Library were searched through July 15, 2016.

STUDY SELECTION:
Randomized controlled trials comparing herbal therapy with no treatment, placebo, or any pharmaceutical medication in children and adolescents (aged 0–18 years) with gastrointestinal disorders were eligible.

DATA EXTRACTION:
Two authors extracted data on study design, patients, interventions, control interventions, results, adverse events, and risk of bias.

RESULTS:
Fourteen trials with 1927 participants suffering from different acute and functional gastrointestinal disorders were included in this review. Promising evidence for effectiveness was found for Potentilla erecta, carob bean juice, and an herbal compound preparation including Matricaria chamomilla in treating diarrhea. Moreover, evidence was found for peppermint oil in decreasing duration, frequency, and severity of pain in children suffering from undifferentiated functional abdominal pain. Furthermore, evidence for effectiveness was found for different fennel preparations (eg, oil, tea, herbal compound) in treating children with infantile colic. No serious adverse events were reported.

LIMITATIONS:
Few studies on specific indications, single herbs, or herbal preparations could be identified.

CONCLUSIONS:
Because of the limited number of studies, results have to be interpreted carefully. To underpin evidence outlined in this review, more rigorous clinical trials are needed.
Clinical Finding and Management of 12 Orofacial Clefts Cases with Nevoid Basal Cell Carcinoma Syndrome
Authors: Lee Lee Mui , Ma Lian , Li Tie Jun 
Published: May 2017

Objective To study the phenotype and overview the clinical management on Cleft Lip and/or Palate (CL/P) with Nevoid Basal Cell Carcinoma Syndrome (NBCCS) patients in Peking University School and Hospital of Stomatology. Design Case series study. Main Outcome Measures To describe the clinical phenotype of 12 CL/P with NBCCS patients who fulfilled the diagnostic criteria as well as to explore clinical management. Results Seven cases (7/12, 58.33%) were classified as bilateral complete cleft lip and palate (BCCLP). Two cases (2/12, 16.67%) were classified as unilateral complete cleft lip and palate (UCCLP). Three cases (1/12, 8.33%) were classified as unilateral complete cleft lip (UCCL), submucosa cleft uvula (SCU), and bifid uvula (BU), respectively. The ratio of male/female was 9/3. Keratocystic odontogenic tumors (KCOTs) were presented in all 12 cases. The most common site was the mandible region (12/12, 100%) followed by the maxilla region (7/12, 58.33%). The diagnostic age of 12 NBCCS with CL/P ranged from 11 to 42 years old (usually postponed to the occurring of KCOTs). The delayed diagnosis of NBCCS can be attributed to its complicated clinical manifestations. In some cases, the mutual effect between the surgical therapy of removing KCOTs and alveolar bone grafting made the team approach (TA) of CL/P more complicated. Conclusion CL/P may become important clinical phenotype in NBCCS. The type of cleft varied, with bilateral cleft lip and palate comprising above 50%. Larger sample sizes are needed to study and confirm this result. KCOTs, as one of the most common clinical feature of NBCCS, make the diagnosis delayed and the TA more difficult because of the occurring time and site. This compels us to improve the diagnostic criteria to make an early diagnosis and explore a better therapeutic protocol for CL/P.