bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional Differences in the Intergenerational Transmission of Family Size in Europe
Authors: Mönkediek Bastian , Rotering Paul , Bras Hilde 
Published: November 2015

AbstractMany studies report positive correlations between family sizes of successive generations, but the degree of correlation varies between countries. However, the majority of these studies are limited in geographical scope and do not consider the role of regional family organisation principles, that is, family systems. In this paper, we investigate to what extent regional family systems explain geographical differences in intergenerational transmission of family size among European regions. Using the large‐scale European Survey of Health, Ageing and Retirement in Europe, we derive indicators of regional family systems based on average frequency of contact and geographical distance between kin. We use a multilevel random coefficients model to test for differences in the transmission between European regions, as well as between sons and daughters. We find a complex regional pattern of family influences on childbearing continuities, with considerable within‐country variation. We observe a direct effect of parental fertility on offspring fertility, although sons show more variance than daughters. This transmission of fertility can be attributed to regional family systems for sons, but not for daughters. Our results demonstrate the importance of using a regional approach –rather than the country‐level approach –to study intergenerational continuities in childbearing. Copyright © 2015 John Wiley & Sons, Ltd.
Factor analysis models via I-divergence optimization
Authors: Finesso Lorenzo , Spreij Peter 
Published: November 2015

Given a positive definite covariance matrix Σ^\documentclass[12pt]{minimal}
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\begin{document}$$\widehat{\Sigma }$$\end{document} of dimension n, we approximate it with a covariance of the form HH⊤+D\documentclass[12pt]{minimal}
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\begin{document}$$HH^\top +D$$\end{document}, where H has a prescribed number k<n\documentclass[12pt]{minimal}
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\begin{document}$$k<n$$\end{document} of columns and D>0\documentclass[12pt]{minimal}
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\begin{document}$$D>0$$\end{document} is diagonal. The quality of the approximation is gauged by the I-divergence between the zero mean normal laws with covariances Σ^\documentclass[12pt]{minimal}
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\begin{document}$$\widehat{\Sigma }$$\end{document} and HH⊤+D\documentclass[12pt]{minimal}
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\begin{document}$$HH^\top +D$$\end{document}, respectively. To determine a pair (H, D) that minimizes the I-divergence we construct, by lifting the minimization into a larger space, an iterative alternating minimization algorithm (AML) à la Csiszár–Tusnády. As it turns out, the proper choice of the enlarged space is crucial for optimization. The convergence of the algorithm is studied, with special attention given to the case where D is singular. The theoretical properties of the AML are compared to those of the popular EM algorithm for exploratory factor analysis. Inspired by the ECME (a Newton–Raphson variation on EM), we develop a similar variant of AML, called ACML, and in a few numerical experiments, we compare the performances of the four algorithms.
Current topics in catecholaminergic polymorphic ventricular tachycardia
Authors: Sumitomo Naokata 
Published: November 2015

AbstractCatecholaminergic polymorphic ventricular tachycardia (CPVT) is induced by emotions or exercise in patients without organic heart disease and may be polymorphic or bidirectional in nature. The prognosis of CPVT is not good, and therefore prevention of sudden death is of utmost importance. Genetic variants of CPVT include RyR2, CASQ2, CALM2, TRD, and possibly KCNJ2 and ANK2 gene mutations. Hypotheses that suggest the causes of CPVT include weakened binding of FKBP12.6 and RyR2, a store overload‐induced Ca2+ release (SOICR), unzipping of intramolecular domain interactions in RyR2, and molecular and functional abnormalities caused by mutations in the CASQ2 gene. The incidence of an RyR2 anomaly in CPVTs is about 35–79%, whereas anomalies in the CASQ2 gene account for 3–5% CPVTs. The ping‐pong theory, suggesting that reciprocating delayed after depolarization induces bigeminy of the right and left bundle branches, may explain the pathogenesis of bidirectional ventricular tachycardia. Flecainide, carvedilol, left sympathetic nerve denervation, and catheter ablation of the PVC may serve as new therapeutic strategies for CPVT while gene‐therapy may be applied to some types of CPVT in the future. Although, not all sudden cardiac deaths in CPVT patients are currently preventable, new medical and interventional therapies may improve CPVT prognosis.
Neither Agamemnon nor Thersites, Achilles nor Margites: The Heraclid Kings of Ancient Macedon
Authors: Moloney E.P. 
Published: November 2015

AbstractIn modern scholarship a distinctly ‘Homeric’ presentation of the ancient Macedonian kings and their court still endures, in spite of recent notes on the use of ‘artifice’ in key ancient accounts. Although the adventures and achievements of Alexander the Great are certainly imbued with epic colour, to extend those literary tropes and topoi to the rule of earlier kings (and to wider Macedonian society) is often to misunderstand and misrepresent the ancient evidence.This paper offers a fresh review of the presentation of the early-Macedonian monarchy in the ancient sources, and considers the depiction of the Argead dynasty in both hostile and more-sympathetic accounts. It highlights the importance of another mythological model for these ancient kings: one that was supremely heroic, but not Homeric. The Argead appropriation of Heracles, Pindar’s ‘hero god’ (ἥρως θεός:Nem.3.22), was a key part of the self-representation of successive kings. Undoubtedly the crucial paradigm for Macedonian rulers, Heracles provided them with an identity and authority that appealed to diverse audiences, and it is time to consider the subtlety of the Argead presentation of their dynasty as Heraclid.
Parental modelling and prompting effects on acceptance of a novel fruit in 2–4-year-old children are dependent on children’s food responsiveness
Authors: Blissett Jackie , Bennett Carmel , Fogel Anna , Harris Gillian , Higgs Suzanne 
Published: November 2015

AbstractFew children consume the recommended portions of fruit or vegetables. This study examined the effects of parental physical prompting and parental modelling in children’s acceptance of a novel fruit (NF) and examined the role of children’s food-approach and food-avoidance traits on NF engagement and consumption. A total of 120 caregiver–child dyads (fifty-four girls, sixty-six boys) participated in this study. Dyads were allocated to one of the following three conditions: physical prompting but no modelling, physical prompting and modelling or a modelling only control condition. Dyads ate a standardised meal containing a portion of a fruit new to the child. Parents completed measures of children’s food approach and avoidance. Willingness to try the NF was observed, and the amount of the NF consumed was measured. Physical prompting but no modelling resulted in greater physical refusal of the NF. There were main effects of enjoyment of food and food fussiness on acceptance. Food responsiveness interacted with condition such that children who were more food responsive had greater NF acceptance in the prompting and modelling conditions in comparison with the modelling only condition. In contrast, children with low food responsiveness had greater acceptance in the modelling control condition than in the prompting but no modelling condition. Physical prompting in the absence of modelling is likely to be detrimental to NF acceptance. Parental use of physical prompting strategies, in combination with modelling of NF intake, may facilitate acceptance of NF, but only in food-responsive children. Modelling consumption best promotes acceptance in children with low food responsiveness.
The politics of numbers: the normative agendas of global benchmarking
Authors: BROOME ANDRÉ , QUIRK JOEL 
Published: November 2015

AbstractGlobal benchmarks have grown exponentially over the last two decades, having been both applied to and developed by states, international organisations, corporations, and non-governmental organisations. As a consequence, global benchmarking is now firmly established as a distinct mode of transnational governance. Benchmarking chiefly involves the development of comparative metrics of performance, which typically take the form of highly stylised comparisons which are generated by translating complex phenomena into numerical values via simplification and extrapolation, commensuration, reification, and symbolic judgements. This process of translation takes what might otherwise be highly contentious normative agendas and converts them into formats that gain credibility through rhetorical claims to neutral and technocratic assessment. This politics of numbers has far-reaching ramifications for transnational governance, including the dimensions and effects of indirect power, expertise and agenda-setting, coordination, regulation and certification, and norm contestation and activism. This Special Issue draws upon an emerging literature to explore how and why benchmarks both align with and expand upon established models of International Relations theory and scholarship. It does so by critically examining the role of global benchmarks in key areas such as state ‘failure’, global supply chains, disaster management, economic governance, corporate social responsibility, and human development.
Governing the world at a distance: the practice of global benchmarking
Authors: BROOME ANDRÉ , QUIRK JOEL 
Published: November 2015

AbstractBenchmarking practices have rapidly diffused throughout the globe in recent years. This can be traced to their popularity amongst non-state actors, such as civil society organisations and corporate actors, as well as states and international organisations (IOs). Benchmarks serve to both ‘neutralise’ and ‘universalise’ a range of overlapping normative values and agendas, including freedom of speech, democracy, human development, environmental protection, poverty alleviation, ‘modern’ statehood, and ‘free’ markets. The proliferation of global benchmarks in these key areas amounts to a comprehensive normative vision regarding what various types of transnational actors should look like, what they should value, and how they should behave. While individual benchmarks routinely differ in terms of scope and application, they all share a common foundation, with normative values and agendas being translated into numerical representations through simplification and extrapolation, commensuration, reification, and symbolic judgements. We argue that the power of benchmarks chiefly stems from their capacity to create the appearance of authoritative expertise on the basis of forms of quantification and numerical representation. This politics of numbers paves the way for the exercise of various forms of indirect power, or ‘governance at a distance’, for the purposes of either status quo legitimation or political reform.
Addressing the compliance gap? UN initiatives to benchmark the human rights performance of states and corporations
Authors: HARRISON JAMES , SEKALALA SHARIFAH 
Published: November 2015

AbstractThis article examines under what conditions benchmarking and associated measurement initiatives produced by UN human rights actors could, and should, play a role in promoting compliance with international human rights norms. It is organised around a comparative analysis of UN benchmarking initiatives for states and corporations. With regard to states, the article argues that ideological misgivings and technical limitations have so far triumphed over aspirations that indicators and benchmarks might play a significant role in increasing compliance with international human rights norms. With regard to corporations, we find that measuring human rights performance has been framed by the recent UN Guiding Principles on Business and Human Rights using a much more expansive and less quantitative set of benchmarks. These latter benchmarks do not appear to be creating conditions under which the human rights performance of corporations is effectively interrogated, and as a result there is a danger of superficial legitimation. Comparative analysis of these two initiatives reveals some of the tensions inherent in utilising benchmarking in transnational efforts to achieve human rights compliance. It also allows us to contribute to broader debates about the quantification of performance and its potential and limitations as a tool of global governance.
Financial knowledge and 401(k) investment performance: a case study
Authors: CLARK ROBERT , LUSARDI ANNAMARIA , MITCHELL OLIVIA S. 
Published: November 2015

AbstractWe explore whether investors who are more financially knowledgeable earn more on their retirement plan investments compared with their less sophisticated counterparts, using a unique new dataset linking administrative data on investment performance and financial knowledge. Results show that the most financially knowledgeable investors: (a) held 18% points more stock than their least knowledgeable counterparts; (b) could anticipate earning 8 basis points per month more in excess returns; (c) had 40% higher portfolio volatility; and (d) held portfolios with about 38% less idiosyncratic risk, as compared with their least savvy counterparts. Our results are qualitatively similar after controlling on observables as well as modeling sample selection. We also examine portfolio changes to assess the potential impact of the financial literacy intervention. Controlling on other factors, those who elected to take the financial literacy survey boosted their equity allocations by 66 basis points and their monthly expected excess returns rose by 2.3 basis points; no significant difference in volatility or non-systematic risk was detected before versus after the survey. While these findings relate to only one firm, we anticipate that they may spur other efforts to enhance financial knowledge in the workplace.
Micro-Foundations of Religion and Public Goods Provision: Belief, Belonging, and Giving in Catholicism and Islam
Authors: Kılınç Ramazan , Warner Carolyn M. 
Published: November 2015

AbstractWhile debates continue about the relationship between state-provided social welfare and religious charities, and whether organized religions are more capable of providing social welfare than is the public sector, less attention has focused on the question of what motivates religious adherents to contribute to the charitable work of their religions. In this article, we examine how adherents of Catholicism and Islam understand their generosity and its relationship to their faith. Through 218 semi-structured interviews with Catholics and Muslims in four cities in France, Ireland, Italy, and Turkey, we find systematic differences between the two religions. Catholics emphasize love of others and Muslims emphasize duty to God. We also find, contrary to expectations of the literature that emphasizes monitoring and sanctioning within groups to obtain cooperation, that Catholics and Muslims see their generosity as also motivated by the positive affect they feel towards their respective communities.
STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling
Authors: Haetscher Nadine , Feuermann Yonatan , Wingert Susanne , Rehage Maike , Thalheimer Frederic B. , Weiser Christian , Bohnenberger Hanibal , Jung Klaus , Schroeder Timm , Serve Hubert , Oellerich Thomas , Hennighausen Lothar , Rieger Michael A. 
Published: November 2015

AbstractHaematopoietic stem cells (HSCs) require the right composition of microRNAs (miR) for proper life-long balanced blood regeneration. Here we show a regulatory circuit that prevents excessive HSC self-renewal by upregulation of miR-193b upon self-renewal promoting thrombopoietin (TPO)-MPL-STAT5 signalling. In turn, miR-193b restricts cytokine signalling, by targeting the receptor tyrosine kinase c-KIT. We generated a miR-193b knockout mouse model to unravel the physiological function of miR-193b in haematopoiesis. MiR-193b−/− mice show a selective gradual enrichment of functional HSCs, which are fully competent in multilineage blood reconstitution upon transplantation. The absence of miR-193b causes an accelerated expansion of HSCs, without altering cell cycle or survival, but by decelerating differentiation. Conversely, ectopic miR-193b expression restricts long-term repopulating HSC expansion and blood reconstitution. MiR-193b-deficient haematopoietic stem and progenitor cells exhibit increased basal and cytokine-induced STAT5 and AKT signalling. This STAT5-induced microRNA provides a negative feedback for excessive signalling to restrict uncontrolled HSC expansion.
Intrinsic cardiovascular autonomic regulatory system of astronauts exposed long-term to microgravity in space: observational study
Authors: Otsuka Kuniaki , Cornelissen Germaine , Kubo Yutaka , Hayashi Mitsutoshi , Yamamoto Naomune , Shibata Koichi , Aiba Tatsuya , Furukawa Satoshi , Ohshima Hiroshi , Mukai Chiaki 
Published: November 2015

AbstractThe fractal scaling of the long-term heart rate variability (HRV) reflects the ‘intrinsic’ autonomic regulatory system. Herein, we examine how microgravity on the ISS affected the power-law scaling β (beta) of astronauts during a long-duration (about 6 months) spaceflight. Ambulatory electrocardiographic (ECG) monitoring was performed on seven healthy astronauts (5 men, 52.0±4.2 years of age) five times: before launch, 24±5 (F01) and 73±5 (F02) days after launch, 15±5 days before return (F03), and after return to Earth. The power-law scaling β was calculated as the slope of the regression line of the power density of the MEM spectrum versus frequency plotted on a log10–log10 scale in the range of 0.0001–0.01 Hz (corresponding to periods of 2.8 h to 1.6 min). β was less negative in space (−0.949±0.061) than on Earth (−1.163±0.075; P<0.025). The difference was more pronounced during the awake than during the rest/sleep span. The circadian amplitude and acrophase (phase of maximum) of β did not differ in space as compared with Earth. An effect of microgravity was detected within 1 month (F01) in space and continued throughout the spaceflight. The intrinsic autonomic regulatory system that protects life under serious environmental conditions on Earth is altered in the microgravity environment, with no change over the 6-month spaceflight. It is thus important to find a way to improve conditions in space and/or in terms of human physiology, not to compromise the intrinsic autonomic regulatory system now that plans are being made to inhabit another planet in the near future.
GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses
Authors: Quandt Dagmar , Rothe Kathrin , Baerwald Christoph , Rossol Manuela 
Published: November 2015

AbstractAlum adjuvanticity is still an unknown mechanism despite the frequent use as vaccine adjuvant in humans. Here we show that Alum-induced inflammasome activation in vitro and in vivo is mediated by the G protein-coupled receptor GPRC6A. The Alum-induced humoral response in vivo was independent of the inflammasome because Nlrp3−/− and ASC−/− mice responded normally to Alum and blockade of IL-1 had no effect on antibody production. In contrast, Alum adjuvanticity was increased in GPRC6A−/− mice resulting in increased antibody responses and increased Th2 cytokine concentrations compared to wildtype mice. In vitro activation of GPRC6A−/− splenic B cells also induced increased IgG1 concentrations compared to wildtype B cells. For the first time, we show GPRC6A expression in B cells, contributing to the direct effects of Alum on those cells. B cell produced immunostimulatory IL-10 is elevated in GPRC6A−/− B cells in vitro and in vivo. Our results demonstrate a dual role of GPRC6A in Alum adjuvanticity. GPCR6A activation by Alum leads to the initiation of innate inflammatory responses whereas it is an important signal for the limitation of adaptive immune responses induced by Alum, partially explained by B cell IL-10.
The prognostic values of CYP2B6 genetic polymorphisms and metastatic sites for advanced breast cancer patients treated with docetaxel and thiotepa
Authors: Song Qingkun , Zhou Xinna , Yu Jing , Dong Ningning , Wang Xiaoli , Yang Huabing , Ren Jun , Kim Lyerly H 
Published: November 2015

AbstractThis study investigated interactive effects of CYP2B6 genotypes and liver metastasis on the prognosis of metastatic breast cancer patients who received combined chemotherapy of docetaxel and thiotepa. Totally 153 patients were retrospectively genotyped rs8192719 (c.1294 + 53C > T) and rs2279343 (c.785A > G). Kaplan-Meier method and Cox Proportional Hazard Regression model were used to estimate the survival. Patients with liver metastasis had worsen prognosis, conferring a 2.26-fold high risk of progression and 1.93-fold high risk of death (p < 0.05). Both CT/TT genotype of rs8192719 (c.1294 + 53C > T) and AG genotype of rs2279343 (c.785A > G) prolonged survival (p < 0.05). Furthermore, among liver metastatic patients, AG genotype of rs2279343 (c.785A > G) was associated with a 47% reduced risk of death and a 6-month-longer overall survival (p < 0.05). Among non-liver metastatic patients, hazard ratios of CT/TT genotype of rs8192719 (c.1294 + 53C > T) were 0.45 for progression and 0.40 for death; and the corresponding survival was improved by 6 months and 16 months, respectively (p < 0.05). Genotypes of CYP2B6 had an interaction with clinical efficacy of docetaxel and thiotepa on metastatic breast cancer patients; and metastatic sites also affected clinical responses. Further therapies should take into account of chemotherapy regimen, genotypes of metabolizing enzymes and metastatic sites for the particular subpopulation.
Vertically Conductive Single-Crystal SiC-Based Bragg Reflector Grown on Si Wafer
Authors: Massoubre David , Wang Li , Hold Leonie , Fernandes Alanna , Chai Jessica , Dimitrijev Sima , Iacopi Alan 
Published: November 2015

AbstractSingle-crystal silicon carbide (SiC) thin-films on silicon (Si) were used for the fabrication and characterization of electrically conductive distributed Bragg reflectors (DBRs) on 100 mm Si wafers. The DBRs, each composed of 3 alternating layers of SiC and Al(Ga)N grown on Si substrates, show high wafer uniformity with a typical maximum reflectance of 54% in the blue spectrum and a stopband (at 80% maximum reflectance) as large as 100 nm. Furthermore, high vertical electrical conduction is also demonstrated resulting to a density of current exceeding 70 A/cm2 above 1.5 V. Such SiC/III-N DBRs with high thermal and electrical conductivities could be used as pseudo-substrate to enhance the efficiency of SiC-based and GaN-based optoelectronic devices on large Si wafers.