bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of ionic liquid on the extraction of actinides and lanthanides with 1,2,3-triazole–modified carbamoylmethylphosphine oxide from nitric acid solutions
Authors: Turanov Alexander N. , Karandashev Vasilii K. , Sharova Elena V. , Genkina Galina K. , Artyushin Oleg I. , Baimukhanova Ayagoz 
Published: December 2017

Abstract
Solvent extraction of U(VI), Th(IV), Am(III) and lanthanides(III) from aqueous nitric acid solutions with 1,2,3-triazole–modified carbamoylmethylphosphine oxide (L) and [C4mim][Tf2N] ionic liquid dissolved in 1,2-dichloroethane was studied. A considerable synergistic effect in this system was observed. This effect is associated with the high hydrophobicity of the IL anions which participate in the formation of metal extracted ion species. The influence of aqueous and organic phases on the extraction efficiency was elucidated and stoichiometry of the complexes extracted was determined. The synergistic effect for metal ion extraction from aqueous nitric acid solutions with compound L and [C4mim][Tf2N] in 1,2-dichloroethane becomes weaker when the acidity of the aqueous phase increases. The partition of Tf2N− anions between the organic and aqueous phases is the major factor governing the extractability of metal ions in the L – IL synergistic system. The interaction of L with HTf2N and HNO3 also substantially affects the efficiency of metal ion extraction.
FGF-FGFR Mediates the Activity-Dependent Dendritogenesis of Layer IV Neurons during Barrel Formation
Authors: Huang Jui-Yen , Lynn Miskus Marisha , Lu Hui-Chen 
Published: December 2017

Fibroblast growth factors (FGFs) and FGF receptors (FGFRs) are known for their potent effects on cell proliferation/differentiation and cortical patterning in the developing brain. However, little is known regarding the roles of FGFs/FGFRs in cortical circuit formation. Here we show thatFgfr1/2/3 andFgf7/9/10/22mRNAs are expressed in the developing primary somatosensory (S1) barrel cortex. Barrel cortex layer IV spiny stellate cells (bSCs) are the primary recipients of ascending sensory information via thalamocortical axons (TCAs). Detail quantification revealed distinctive phases for bSC dendritogenesis: orienting dendrites toward TCAs, addingde novodendritic segments, and elongating dendritic length, while maintaining dendritic patterns. DeletingFgfr1/2/3in bSCs had minimal impact on dendritic polarity but transiently increased the number of dendritic segments. However, 6 d later, FGFR1/2/3 loss of function reduced dendritic branch numbers. These data suggest that FGFs/FGFRs have a role in stabilizing dendritic patterning. Depolarization of cultured mouse cortical neurons upregulated the levels of severalFgf/FgfrmRNAs within 2 h.In vivo, within 6 h of systemic kainic acid administration at postnatal day 6, mRNA levels ofFgf9,Fgf10,Fgfr2c, andFgfr3bin S1 cortices were enhanced, and this was accompanied by exuberant dendritogenesis of bSCs by 24 h. DeletingFgfr1/2/3abolished kainic acid-induced bSC dendritic overgrowth. Finally, FGF9/10 gain of function also resulted in extensive dendritogenesis. Together, our data suggest that FGFs/FGFRs can be regulated by glutamate transmission to modulate/stabilize bSC dendritic complexity. Both male and female mice were used for our study.SIGNIFICANCE STATEMENTGlutamatergic transmission plays critical roles in cortical circuit formation. Its dysregulation has been proposed as a core factor in the etiology of many neurological diseases. We found that excessive glutamate transmission upregulated mRNA expression ofFgfrsand their ligandsFgfs. DeletingFgfr1/2/3not only impaired bSC dendritogenesis but also abolished glutamate transmission-induced dendritic overgrowth. Overexpressing FGF9 or FGF10 in cortical glutamatergic neurons results in excessive dendritic outgrowth within 24 h, resembling the changes induced by excessive glutamate transmission. Our findings provide strong evidence for the physiological role of fibroblast growth factors (FGFs) and FGF receptors (FGFRs) in establishing and maintaining cortical circuits. Perturbing the expression levels of FGFs/FGFRs by excessive glutamatergic neurotransmission could lead to abnormal neuronal circuits, which may contribute to neurological and psychiatric disease.
Sleep in Humans Stabilizes Pattern Separation Performance
Authors: Hanert Annika , Weber Frederik D. , Pedersen Anya , Born Jan , Bartsch Thorsten 
Published: December 2017

Replay of hippocampal neural representations during sleep is thought to promote systems consolidation of declarative memory. How this reprocessing of memory during sleep affects the hippocampal representation itself, is unclear. Here we tested hippocampal stimulus processing (i.e., pattern separation) before and after periods of sleep and wakefulness in humans (female and male participants). Pattern separation deteriorated across the wake period but remained stable across sleep (p= 0.013) with this sleep–wake difference being most pronounced for stimuli with low similarity to targets (p= 0.006). Stimuli with the highest similarity showed a reversed pattern with reduced pattern separation performance after sleep (p= 0.038). Pattern separation performance was positively correlated with sleep spindle density, slow oscillation density, and theta power phase-locked to slow oscillations. Sleep, presumably by neural memory replay, shapes hippocampal representations and enhances computations of pattern separation to subsequent presentation of similar stimuli.SIGNIFICANCE STATEMENTThe consolidation of hippocampus-dependent memories is causally related to reactivation during sleep of previously encoded representations. Here, we show that reactivation-based consolidation processes during sleep shape the hippocampal representation itself. We studied the effect of sleep and wakefulness on pattern separation (i.e., orthogonalization of similar representations) and completion performance (i.e., recall of a memory in light of noisy input) that are essential cognitive elements of encoding and retrieval of information by the hippocampus. Our results demonstrate that pattern separation was stabilized after sleep but diminished after wakefulness. We further showed that pattern separation was related to EEG oscillatory parameters of non-REM sleep serving as markers of sleep-dependent memory consolidation and hippocampal reactivation.
The Ubiquitin E3 Ligase TRAF6 Exacerbates Ischemic Stroke by Ubiquitinating and Activating Rac1
Authors: Li Tao , Qin Juan-Juan , Yang Xia , Ji Yan-Xiao , Guo Fangliang , Cheng Wen-Lin , Wu Xiaolin , Gong Fu-Han , Hong Ying , Zhu Xue-Yong , Gong Jun , Wang Zhihua , Huang Zan , She Zhi-Gang , Li Hongliang 
Published: December 2017

Stroke is one of the leading causes of morbidity and mortality worldwide. Inflammation, oxidative stress, apoptosis, and excitotoxicity contribute to neuronal death during ischemic stroke; however, the mechanisms underlying these complicated pathophysiological processes remain to be fully elucidated. Here, we found that the expression of tumor necrosis factor receptor-associated factor 6 (TRAF6) was markedly increased after cerebral ischemia/reperfusion (I/R) in mice. TRAF6 ablation in male mice decreased the infarct volume and neurological deficit scores and decreased proinflammatory signaling, oxidative stress, and neuronal death after cerebral I/R, whereas transgenic overexpression of TRAF6 in male mice exhibited the opposite effects. Mechanistically, we demonstrated that TRAF6 induced Rac1 activation and consequently promoted I/R injury by directly binding and ubiquitinating Rac1. Either functionally mutating the TRAF6 ubiquitination site on Rac1 or inactivating Rac1 with a specific inhibitor reversed the deleterious effects of TRAF6 overexpression during I/R injury. In conclusion, our study demonstrated that TRAF6 is a key promoter of ischemic signaling cascades and neuronal death after cerebral I/R injury. Therefore, the TRAF6/Rac1 pathway might be a promising target to attenuate cerebral I/R injury.SIGNIFICANCE STATEMENTStroke is one of the most severe and devastating neurological diseases globally. The complicated pathophysiological processes restrict the translation of potential therapeutic targets into medicine. Further elucidating the molecular mechanisms underlying cerebral ischemia/reperfusion injury may open a new window for pharmacological interventions to promote recovery from stroke. Our study revealed that ischemia-induced tumor necrosis factor receptor-associated factor 6 (TRAF6) upregulation binds and ubiquitinates Rac1 directly, which promotes neuron death through neuroinflammation and neuro-oxidative signals. Therefore, precisely targeting the TRAF6-Rac1 axis may provide a novel therapeutic strategy for stroke recovery.
Testosterone level and risk of type 2 diabetes in men: a systematic review and meta-analysis
Authors: Yao Qiu-ming , Wang Bin , An Xiao-fei , Zhang Jin-an , Ding Liumei 
Published: December 2017

Background
Type 2 diabetes is a risk factor for testosterone deficiency and impaired sex steroid status. Some studies also investigated the association of testosterone level with diabetes risk in men, but reported controversial findings. To clarify this issue, we conducted a systematic review and meta-analysis.

Methods
PubMed, EMBASE and Web of Science were searched for eligible cohort or nested case–control studies published up to August 15, 2017. Meta-analysis was used to calculate the pooled relative risk (RR) of type 2 diabetes associated with higher testosterone level.

Results
Thirteen cohort or nested case–control studies with 16,709 participants were included. Meta-analysis showed that higher total testosterone level could significantly decrease the risk of type 2 diabetes in men (RR = 0.65; 95% CI 0.50–0.84; P = 0.001), and higher free testosterone level could also decrease the risk of type 2 diabetes in men (RR = 0.94; 95% CI 0.90–0.99; P = 0.014). After excluding two studies that did not calculate RRs by quartiles of testosterone levels, both higher total testosterone and free testosterone levels could decrease the risk of type 2 diabetes in men, and the pooled RRs were 0.62 (95% CI 0.51–0.76; P < 0.001) and 0.77 (95% CI 0.61–0.98; P = 0.03), respectively.

Conclusion
This meta-analysis suggests that higher testosterone level can significantly decrease the risk of type 2 diabetes in men. Therefore, combined with previous researches, the findings above suggest a reverse-causality scenario in the relation between testosterone deficiency and risk of type 2 diabetes in men.
Effect of surgical menopause on serum lipid profile-a prospective study
Authors: B. Renymol , N. R. Ambili , Unnikrishnan Kartha T. D. 
Published: December 2017

Background:Menopause marks the onset of cessation of ovarian function which is associated with changes in cardiovascular risk factors especially an unfavourable change in lipid profile. This is more pronounced is perimenopausal females who have undergone total hysterectomy with bilateral sapingo oopherectomy. This study aimed at looking into the changes occurring in the lipid profile and other cardiovascular risk in patients who have underwent oopherectomy over a 3 months period.Methods: The study was conducted as a case control one. We studied 70 consecutive perimenopausal patients admitted in a tertiary care teaching medical college hospital in Kerala, South India who were admitted for hysterectomy and bilateral oopherectomy over a 1year period. The lipid profile and anthropometric measurement with blood pressure recording was done prior to surgery and the same patients were followed up after 3 months when the cardiovascular risk assessment and lipid profile estimation were repeated. Here, the cases acted as controls after the end of third month.Results: It was found that after the end of 3 months of surgical menopause there was no significant change in body mass index, waist hip ratio or systolic BP. However, the DBP was higher in patients after surgery (78.68±7.94 vs 83.31±11.03, P <0.001). There was also statistically significant increase in total cholesterol (166.07±28.22 vs 242.94±45.65 [P<0.001]), TG (129.33±31.16 vs 177.06±50.57 P<0.001) and LDLc (107.83±20.06 vs 166.73±48.51 P>0.001). The HDLc was found to be 27% after 3 months of surgical menopause (59.31±8.22 vs 43.73±35 P>0.001.Conclusions: Thus, it was concluded that there was a significant unfavourable effects on lipid profile and diastolic blood pressure 3 months after surgical menopause.
PENINGKATAN KEMAMPUAN MEMBACA CEPAT DENGAN METODE SQ3R PADA SISWA SD
Authors: Nurani Heppi Isti , Suhita Raheni , Suryanto Edy 
Published: December 2017

<p>Penelitian ini bertujuan meningkatkan kualitas: (1) proses pembelajaran membaca cepat dengan metode SQ3R dan (2) hasil pembelajaran membaca cepat dengan metode SQ3R. Penelitian tindakan kelas (PTK) ini dilaksanakan di kelas V SD Negeri I Karang Duren. Sumber data diperoleh dari tempat dan peristiwa, partisipan, dan dokumen. Pengumpulan data dilakukan dengan cara observasi, wawancara, tes, dan angket. Teknik validasi data menggunakan triangulasi sumber data, triangulasi metode, dan revieu partisipan. Data dianalisis dengan teknik analisis komparatif deskriptif. Hasil penelitian disimpulkan bahwa metode <em>SQ3R</em> dapat meningkatkan kualitas proses dan kualitas pembelajaran membaca cepat. Peningkatan kualitas proses terefleksi dari keaktifan siswa dalam mengikuti apersepsi, perhatian, serta minat dan motivasi. Ketuntasan siswa dalam belajar juga mengalami peningkatan. Peningkatan kualitas hasil ditunjukkan perkembangan dari 52,6% pada siklus I menjadi 68% pada siklus II, dan 84,2% pada siklus III.</p><p><strong> </strong></p><p><strong>Kata kunci:</strong> kemampuan membaca , metode <em>SQ3R</em><em>, </em>membaca cepat<strong></strong></p>
PENERAPAN MODEL PEMBELAJARAN POE DENGAN METODE PRAKTIKUM UNTUK MENINGKATKAN RASA INGIN TAHU DAN PRESTASI BELAJAR KIMIA SISWA
Authors: Pamungkas Maya Sih Hika , Mulyani Sri , Saputro Sulistyo 
Published: December 2017

<p>Penelitian bertujuan untuk meningkatkan rasa ingin tahu dan prestasi belajar kimia dengan model <em>predict</em>-<em>observe</em>-<em>explain</em> (POE) dan metode praktikum pada materi pokok kelarutan dan hasil kali kelarutan. Penelitian tindakan kelas ini ini terdiri dari dua siklus dan setiap siklus memiliki tahapan perencanaan, pelaksanaan, observasi dan refleksi. Subjek penelitian adalah siswa kelas XI MIA 2 SMA Negeri 2 Surakarta. Sum­ber data berasal dari guru dan siswa. Data dikumpulkan melalui wa­wancara, observasi, angket, dan tes. Data dianalisis dengan teknik deskriptif kualitatif. Hasil penelitian disimpulkan bahwa model dan metode yang diterapkan dapat meningkatkan rasa ingin tahu siswa pada materi pokok kelarutan dan hasil kali kelarutan (siklus I 64,3% dan siklus II 78,6%) dan prestasi belajar kimia siswa pada materi pokok kelarutan dan hasil kali kelarutan (pada siklus I, aspek pengetahuan 53,6% dan siklus II menjadi 78,6%; siklus I, aspek sikap 89,3% dan siklus II menjadi 96,4% ; dan aspek keterampilan sebesar 100% pada siklus I).</p><p><strong> </strong></p><p><strong>Kata kunci: </strong>model predict-observe-explain (POE), metode praktikum, rasa ingin ta­hu, prestasi belajar kimia</p>
Roller-Ski Aerobic High-Intensity Interval Training Improves the VO2max and Anaerobic Power in Cross-Country Skiers
Authors: ATEŞ BAHAR , ÇETİN Ebru 
Published: December 2017

The purpose of this study was to investigate the 8-week of roller-ski aerobic high-intensity interval training on aerobic and anaerobic power in cross-country skiers. 10 male [age, 18,28±2,1 years; height, 171,26±4,12 cm; weight, 61,39±6,28 kg] and 8 female [age, 16,05±0.3 years; height, 158,3±6,47 cm; weight, 49,34±0.7 kg] junior cross-country skiers completed the study. All skiers performed 2x2-km all-out uphill intervals with roller-skis, 3 times a week, in addition to their traditional training program. Measurements included VO2max, anaerobic power, and also for 2-km time-trial performance. All values were listed as pre-to post-test mean [±SD], significant level, and percentage changes [%]. Pre-to post-testing changes in VO2max, anaerobic power, and also 2-km time-trial performance were significantly higher during all post-test trials in all groups [p<0.005]. As a result, we suggest that the skiers should integrate the roller-ski aerobic high-intensity interval uphill models in their training programs for improving performance.
The Effect of Bio/Neurofeedback Training on Performance, Audio and Visual Attention in Elite Shooters
Authors: Bagheri asl Farzaneh 
Published: December 2017

The aim of this study was the effect of Bio/Neurofeedback training on performance, audio and visual attention of elite shooters. In this study 36 elite shooters of Kermanshah Province participated. They divided in three groups. Two groups were experimental groups how participated biofeedback and neurofeedback training and one group was control group. All participants were tried that their trainings as well as the number of shoots were closely controlled in order to assure their physical and special trainings. In this study, for attention affects the computerized Integrated Visual and Auditory test (IVA) was used. This test has been considered as both a pretest and a posttest after the therapeutic intervention in three groups. The score of shooting also were collected before and after intervention. Each athlete in neurofeedback training group carried out the neurofeedback training for 20 sessions, each lasting 45 minutes. To do so, both auricles and T3 and PZ of each individual were cleaned using alcohol and new-perp gel to prepare for the neurofeedback training. The biofeedback training was heart rate and respiratory training. To compare the results of the pretest and the posttest in each group, the dependent t-test was used. For compare three groups we used ANOVA test. The significance level was set at 0.05. The results indicated that there is a significant difference in three groups. It indicates a significant increase in the total score for attention after the implementation of the biofeedback and neurofeedback training. The results showed that the attention mean scores in three visual, audio, and total variables were higher in the posttest than in the pretest for two experimental groups. The results also indicated that the scores of the shoots were improved after training. According the research finding, we can be said that the neurofeedback and biofeedback training act on the waves of the sensory-motor beats and which are responsible for coordinating the sensory-motor acts of the brain waves and physiology parameters (Heart and respiratory systems), and strengthen these waves in addition to the beta ones and rate of the heart and respiration. This leads to regulating the performance and attention.
Estudo da atividade antifúngica do óleo essencial de Syzygium aromaticum (L.) Merr & Perry (cravo-da-índia) no fungo Penicillium roqueforti
Authors: Teixeira Juraci Lourenço , Oliveira Mariana Mara de , Gaspar Junior Pascoal José 
Published: December 2017

Estudos recentes de compostos naturais de plantas medicinais e condimentares relatam a sua utilização na preservação de alimentos e no controle de patógenos veiculados na alimentação humana e animal. O presente estudo teve como objetivo avaliar, in vitro, o efeito do óleo essencial de Sygygium aromaticum(L.) MERR. & PERRY (cravo­da­índia), extraído por arraste de vapor e por solventes, sobre o crescimento micelial do fungo Penicillium roqueforti. O óleo sofreu o processo de extração em um protótipo, obtendo­se dois tipos de óleo de uma mesma destilação, observando um mais denso e outro menos denso que a água. A extração por solventes foi realizada de acordo com a metodologia proposta por Cechinel Filho e Yunes (1998). Foram testados todos os extratos nas concentrações de 1,00, 2,00, 3,00, 4,00, e 5,00 1⁄4g/L., usando como meio de cultura MEA (Malte Extrato de Agar). Os resultados mais efetivos sobre o crescimento micelial do fungo Penicillium roqueforti foram o óleo mais denso e o óleo extraído por hexano, na concentração máxima testada de 5,00 1⁄4g/L, ocorrendo, assim, a inibição total do crescimento micelial.
Formação acadêmica superior em ciências contábeis no Centro Universitário de Formiga X atuação do contabilista
Authors: Sousa Lorena Carmen de , Oliveira Camila Aparecida de , Fonseca Diego Rittiele da , Miranda Elba Caroline Queiroz , Pinto Joilson Almeida , Oliveira Luis Carlos Ferreira de Sousa 
Published: December 2017

As diretrizes de Graduação em Ciências Contábeis no Brasil têm­se fortalecido, consideravelmente, na atualidade. A busca pela formação acadêmica se acentua, ao passo que é necessário adquirir habilidades conceituais, capazes de nortear a carreira profissional dos estudantes do nível superior de ensino. A relevância que o acadêmico em Ciências Contábeis alcançou nos últimos anos permite definir a importância das responsabilidades do contador, frente à sua atuação profissional. Tendo em mente essas abordagens, objetivou­se verificar se a formação acadêmica no curso de Ciências Contábeis da Instituição de Ensino Superior, UNIFOR­MG, oferece suporte necessário para o exercício do profissional contábil no mercado de trabalho. Portanto, para o desenvolvimento da pesquisa, foi utilizada a técnica de aplicação de questionários como instrumento de coleta dos dados. Os resultados alcançados revelaram que o curso de Ciências Contábeis do UNIFOR­MG aprimora­se, de acordo com as exigências da atualidade, com o intuito de predispor os acadêmicos deste para o mercado de trabalho, oferecendo subsídios importantes para a formação acadêmica do universitário. Todavia, a predominância dos embasamentos teóricos faz com que a prática do ensino seja minoritária no percurso estudantil, o que representa um aspecto a ser aprimorado, uma vez que esta é essencial para o exercício contábil.
Modelagem e desenvolvimento de um software de otimização no co-processamento de resíduos na indústria do cimento envolvendo custos, qualidade e impacto ambiental
Authors: Carpio Ricardo Carrasco , Santos Aladir Horácio dos , Guimarães Marcone Dos Santos , Barbosa Ezequiel Antônio , Costa Mateus Rodrigues 
Published: December 2017

Atualmente a indústria de cimento vem procurando, soluções no que diz respeito aos combustíveis utilizados para a fabricação do clínquer, a eletricidade consumida no processo de produção, ao controle das emissões de poluentes, à utilização de adições ativas, e tudo isto, sem perder a qualidade de seu principal produto final, que é o cimento. Estas soluções devem atender aos requisitos de qualidade do produto e às restrições ambientais, de modo a permitir alcançar um menor custo final de produção. Nesta proposta de trabalho, pretende­se desenvolver um software para otimizar a dosagem e homogeneização das matérias­primas e combustíveis na fabricação do clínquer, tendo como possibilidade patentear o produto final do presente trabalho de pesquisa. ssim mesmo, através desse software será possível avaliar os efeitos dos resíduos utilizados, na qualidade do clínquer, no meio ambiente, no custo de fabricação e no consumo de energia elétrica, tendo como objetivo garantir uma melhor estabilidade da operação do forno, a redução no consumo de energia e a minimização do impacto ambiental. Por outro lado, este software será de ajuda à indústria do cimento para uma rápida avaliação dos diferentes tipos de combustíveis alternativos que possam ser utilizados como substitutos dos combustíveis tradicionais (co­processamento). Para desenvolvimento do software de otimização será utilizada a linguagem Java. A escolha deste aplicativo atende ao objetivo de ser uma das linguagens de programação mais difundidas na indústria e no meio acadêmico.