bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Synthesis of Benzimidazole Carboxamide Cysteine Protease Inhibitors as Promising Anti-leishmanial Agents
Authors: Akhter Gowsia , Hamid Hinna , Beg Mirza A. , Tantray Mushtaq A. , Dhawan Bharti , Alam Mohammad Sarwar , Selvapandiyan Angamuthu , Sayeed ur Rehman  , Kalicharan Sharma 
Published: October 2024

Introduction:
More than 20 protozoan species of Leishmania are responsible for
causing Leishmaniasis, an infection spread by blood-feeding phlebotomine sandflies. A narrow
pool of drugs is currently available rendering the current drug stratagem to treat this infection .
Development of novel, less toxic, and more effective regimens is thus a need of the hour. Design
and synthesis of benzo[d]imidazole carboxamides as agents to combat Leishmaniasis are
also required.

Methods:
14 benzo[d]imidazole carboxamides were synthesized and gauged against L. donovani
promastigotes and intramacrophage amastigote forms. All of the tested compounds exhibited
significant anti-promastigote properties with IC50 well below 10 uM. Compounds 4a,
4b, and 4d, showing the highest anti-parasitic activity against promastigote forms (IC50 0.91-
1.33 μM), were also found to be associated with better anti-leishmanial potential (IC50 0.78-
1.67 μM) against the intramacrophage amastigotes comparable to Amphotericin-B (0.13 μM),
a drug used for Leishmaniasis. Compound (4a), namely N-(2-(trifluoromethyl)-1Hbenzo[
d]imidazol-5-yl)benzo[d][1,3]-5-carboxamide-dioxole, was found to be most potent
against L. donovani amastigotes among all the tested compounds, and demonstrated better antileishmanial
properties (IC50 0.78 μM) when compared to the standard. Compound 4a was also
assessed for its toxicity profile against THP-1 human monocytic cells. To establish the molecular
target(s) in silico, molecular docking studies were performed against cysteine protease,
a putative virulence factor of Leishmania parasites, and nucleoside diphosphate kinase, an enzyme
with a critical role in nucleotide recycling, also associated with resistance in Leishmania
strains. Compound 4a showed better binding affinity than the standard to these targets; furthermore,
the molecular dynamic simulation studies further affirmed the stability of compound
4a, within the active site of the targets. In vitro, cysteine protease inhibitory activity
(IC50 8.53 μM) using Bz-Arg-AMC hydrochloride fluorogenic peptide substrate established the
promising potential of 4a as a cysteine protease inhibitor.

Result:
Computational ADMET analysis indicated appropriate pharmacokinetic profile and
physicochemical characteristics for all members of the synthesized library.

Conclusion:
Both in vitro and in silico studies indicate that the synthesized imidazole carboxamides
can act as potent hits and that N-(2-(trifluoromethyl)-1H-benzo[d]imidazol-5-
yl)benzo[d][1,3]-5-carboxamide-dioxole 4a can be an effective hit molecule which can be further
developed into potent lead molecule (s) to fight Leishmania donovani.
The Effect of COVID-19 Lockdown Among Adolescents with Type 1 Diabetes: A Systematic Review and Meta-Analysis
Authors: Momani Aaliyah , Halimi Aram , Nazari Seyed Saeed Hashemi , Al-Marzouqi Zalikha , Mosavi Jarrahi Alireza Mosavi , Al-Yateem Nabeel , Rahman Syed Azizur , Al-Marzouqi Amina 
Published: October 2024

Objective:
The aim of this study was to assess how the lockdown of the COVID-19
pandemic had affected the glycaemic control of adolescents aged 10-19 with type 1 diabetes.

Methods:
A comprehensive search of literature was performed in PubMed, Scopus, Web of Science,
and ProQuest. Published articles up to September 2022 were included. The Glucose Monitoring
Index (GMI) and HbA1c level were defined as outcome variables. Average glucose level was
found to be a common variable in both HbA1c levels and GMI; therefore, HbA1c and GMI were
converted to average glucose (mg/dL) using appropriate formulas. Studies reported the outcomes
in two or three periods (pre-lockdown, lockdown, and post-lockdown) were included in the analysis.
A paired wise meta-analysis was performed among the studies that reported all three periods.
Homogeneity across studies was assessed using I2 statistic.

Result:
Fourteen studies were included in the study. The pooled average glucose during the lockdown
decreased to 166.9 mg/dL (95% CI, 153.78, 180.02) from 205.793 mg/dL (95% CI, 188.412,
223.173) during the pre-lockdown period, then it increased to 204.23 mg/dL (95% CI, 186.17,
222.29) during the post-lockdown period. A paired wise meta-analysis indicated a reduction in average
glucose levels. However, it was not statistically significant, possibly due to the small number
of studies that reported data from all three periods.

Conclusion:
Although the descriptive analysis of our study showed that the lockdown had affected
(decreased) the average glucose level among adolescents with type 1 diabetes, this was not statistically
significant in the pooled analysis.
Investigation of Voltametric Behavior and Antioxidant Activity of Vanillin-based Chalcone Compound
Authors: Cogalmis Fatma Tuba , Yildiz Gulcemal , Sütay Berkay , Korkmaz Burak , Aydogmus Zeynep , Senkal Bahire Filiz 
Published: October 2024

Background:
Chalcone-type molecules are significant compounds due to their biocompatible
properties. This study aimed to examine the electrochemical properties of vanillin chalcone
monomer (VC) and its polymer (PANI-VC), as well as to investigate the antioxidant properties of the
vanillin chalcone monomer.

Methods:
VC and PANI-VC were synthesized and characterized using FTIR and UV-Vis spectroscopy.
The electrochemical properties of both compounds were investigated using cyclic voltammetry.
The antioxidant activity of the monomer was assessed using the DPPH (2,2-Diphenyl-1-
picrylhydrazyl) assay.

Results:
Two oxidation peaks and one reduction peak were observed for both the monomer and polymer
at pH 3 using cyclic voltammetry in Britton-Robinson buffer solution. The electrochemical
oxidation mechanisms of the monomer and polymer were investigated by cyclic voltammetry, and
the effects of pH and scan rate were also studied. The electrochemical oxidation mechanism was
further evaluated using density functional theory (DFT) computations, revealing that the electrochemical
process is adsorption-controlled. The antioxidant activity of VC was assessed using the
DPPH (2,2-Diphenyl-1-picrylhydrazyl) method.

Conclusion:
Chalcone-type compounds are known for their potential antioxidant, antimicrobial,
antifungal, antibacterial, antiviral, antimalarial, and neuroprotective effects. In this study, the electrochemical
properties of the synthesized vanillin chalcone monomer and its polymer were examined,
and their electrochemical mechanisms were evaluated through DFT calculations. The antioxidant
properties of the monomer were compared to those of ascorbic acid using the DPPH method, revealing
that the vanillin chalcone monomer possesses significant antioxidant activity.
A Review of Strawberry Picking Patents
Authors: Bao Yudong , Zhang Jingyang 
Published: October 2024

Background:
As the demand for strawberries increases, the growing area of strawberries
is also increasing. However, the main method of harvesting strawberries is the traditional artificial
harvest, so the harvest is the most time-consuming and laborious operation in the production chain.

Objective:
By summarizing the recent years of strawberry harvest research, some valuable conclusions
have been drawn to predict the future development of strobing machinery, providing reference
to researchers in relevant fields.

Methods:
This paper examines the patents of recent strawberry harvesting machinery, by comparing
the characteristics of various mechanical structures, to plan the research route of the future strawberry
machine.

Results:
The emerging problems and future directions of technology are identified through analysis
and discussion of existing technologies.

Conclusion:
Improvements in its structure alone do not meet the demands of modernization, and
strawberry harvesting machines need to be more intelligent and integrated and use more efficient
ways. More relevant patents are needed to be invented.
Utility of the Non-Alcoholic Fatty Liver Disease Fibrosis Score in the Evaluation of Individuals with Medically-Complicated Obesity: A Retrospective Study
Authors: Nath Anand , Shope Timothy R. , Pardo Lameda Ivanesa L. , Koch Timothy R. 
Published: October 2024

Background:
Individuals with high body mass index (BMI) are at risk for chronic liver disease. Liver biopsy is a gold standard for the diagnosis of liver disease, as well as for determining the NAFLD activity score and fibrosis stage. Blood alanine aminotransferase (ALT) can support the presence of steatohepatitis, while the non-alcoholic fatty liver disease (NAFLD) fibrosis score (using clinical features and blood testing) may predict fibrosis. Based on prior studies, it is not clear whether the NAFLD fibrosis score is predictive of the NAFLD activity score or fibrosis stage.

Aims:
The aim was to examine whether clinical features and blood testing can identify the risk of chronic liver disease in those individuals with high BMI.

Objective:
Individuals with high BMI who may benefit from bariatric surgery were examined for the prevalence of steatohepatitis and for potential relationships between the NAFLD fibrosis score and the NAFLD activity score and fibrosis stage.

Methods:
This was a retrospective study of 593 consecutive individuals evaluated for bariatric surgery who underwent blood testing. Seventy individuals with a mean BMI of 49.9 kg/m2 un-derwent liver biopsy at surgery.

Results:
Elevated ALT was present in 102 subjects (17.2%). The correlation coefficient (R: 0.025; p = .83) between the NAFLD fibrosis score and NAFLD activity score was not significant, but there was a weak correlation between the NAFLD fibrosis score and fibrosis stage (R = 0.262; p = .028). Two individuals (3%) had cirrhosis.

Conclusion:
Elevated ALT may support the presence of liver disease in individuals with high BMI. There is a weak correlation between the NAFLD fibrosis score and the fibrosis stage. Fur-ther work is required to determine whether specific blood and clinical findings can be useful in making clinical decisions with regards to bariatric surgery in those individuals with high BMI.
Juvenilização da Educação de Jovens e Adultos no Ensino Médio na Bahia
Authors: Silva José Humerto da , Zan Dirce Djanira Pacheco , Santos Carla Liane Nascimento dos 
Published: October 2024

Este artigo resulta de um estudo sobre a Juvenilização da Educação de Jovens Adultos (EJA), no ensino médio, no estado da Bahia. Tem como foco principal, desvelar quem são os jovens que estruturam esse fenômeno no estado. Para alçar o objetivo central da pesquisa, percorreu um caminho metodológico aglutinou método e técnicas de pesquisa, numa abordagem que articulou dados quantitativos com fontes teóricas já produzidas. Entre os autores referenciados, destacam-se: Bourdieu (1983), Pais (1990), Alves (2008) Spósito (2002), Silva (2009, 2012, 2023), Haddad e Di Pierro (2000), Paiva (1987), Brunel (2004), Rummert (2007), Zan(2013), entre outros. Triangulou com o campo teórico o levantamento de dados do número de matrícula dos estudantes da EJA no Brasil e Bahia e, destacadamente no nível médio (CENSO MEC/INEP, 2013-2023); dados de jovens de 15 a 29 anos, segundo a situação de trabalho e estudo e faixa etária. (Bahia, 2012/2022 da PNAC- Pesquisa Nacional por Amostra de Domicílio Contínua e PNADC). O resultado e a análise, oriundos da triangulação das diferentes fontes, estão organizados, além das Notas Introdutórias e considerações Finais, em três seções, a saber: “A Juventude no Ensino Médio: que juventude é essa que acessa a EJA”; “A Juvenilização da EJA no ensino médio: Quando ‘novos’ sujeitos entram em cena”; “A presença de Jovens no Ensino Médio da EJA no estado da Bahia”; “Os Jovens no Ensino Médio da EJA no Estado da Bahia”. A pesquisa conclui que os jovens, inseridos na EJA do Ensino Médio, têm “rosto” definido. Na sua grande maioria, são jovens entre 15-24 anos, pobres, pretos e residentes na zona urbana do Estado da Bahia. Trata-se, portanto, de uma juventude que não usufrui de um período exclusivo de preparação para a vida adulta- moratória social e que, desde muito cedo, inicia sua atividade de trabalho impactando de forma perversa sua trajetória escolar

Palavras chaves: EJA. Juventude. Juvenilização da EJA
The WeThrive App and Its Impact on Adolescents Who Menstruate: Qualitative Study
Authors: MacNeil Nora , Price Victoria , Pike Meghan 
Published: October 2024

Background
Heavy menstrual bleeding (HMB) affects up to 37% of adolescents. Without recognition, HMB can lead to other medical conditions resulting in diminished health-related quality of life. WeThrive, a new mobile health (mHealth) app, implements the pictorial bleeding assessment chart to identify HMB, and the adolescent Menstrual Bleeding Questionnaire to measure the effects of HMB on adolescents’ health-related quality of life. If HMB is identified, WeThrive will connect users to local clinics for further assessment of their menstrual bleeding with a health care provider.

Objective
This study aimed to describe adolescents’ experiences using WeThrive app.

Methods
This qualitative study was approved by the local Research Ethics Board in Halifax, Nova Scotia, and informed consent was provided by all participants. Individual semistructured interviews were held via videoconference with adolescents younger than 18 years, who had at least 1 menstrual period and had used WeThrive at least once. Interview transcripts were thematically analyzed by 2 investigators (MP and NMN) independently, and the κ statistic was calculated to determine the strength of correlation in themes.

Results
Five adolescents (mean age 15.5, range 13-18 years), participated in the interviews. All participants stated that WeThrive helps them better understand their menstrual periods by predicting period onset, recognizing menstrual symptoms, and identifying HMB. Four themes were identified: (1) the importance of visual features and usability, (2) newly obtained knowledge using WeThrive, (3) feature use depends on menstrual health, and (4) trustworthiness. There was substantial agreement on the identified themes (κ=0.73).

Conclusions
WeThrive is visually appealing, and trustworthy, and helps users better understand their menstrual periods, including identifying HMB. By identifying HMB early, WeThrive has the potential to improve the recognition of bleeding disorders and iron deficiency in adolescents. WeThrive is a useful tool to help adolescents better understand their menstrual periods.
Relasi Teks, Praktik Diskursif dan Sosiokultural Film Dokumenter “Ice Cold: Murder, Coffee and Jessica Wongso”
Authors: Rosita Eva , Tarmini Wini , Suryanling  
Published: October 2024

Media massa berperan penting membentuk narasi dan memengaruhi pandangan publik mengenai isu-isu kontroversial, sebagaimana dipaparkan dalam film dokumenter "Ice Cold: Murder, Coffee and Jessica Wongso". Penelitian ini bertujuan untuk mengkaji hubungan antara narasi teks, dinamika praktik diskursif, serta praktik sosio-kultural, menggunakan kerangka kerja Analisis Wacana Kritis Norman Fairclough. Metodologi deskriptif kualitatif digunakan untuk mendiskusikan dimensi-dimensi teks, praktik diskursif, serta praktik sosiokultural. Teknik pengumpulan data dilakukan melalui dokumentasi film, observasi wacana, metode simak bebas libat cakap serta teknik catat. Analisis data meliputi transkripsi, pembacaan intensif, dan telaah struktur mikro, meso, serta makro. Hasil penelitian menunjukkan representasi negatif terhadap Jessica Wongso melalui pemilihan kosakata, tata bahasa, dan struktur kalimat yang cenderung berkonotasi negatif. Pada tataran praktik diskursif, interaksi kompleks antara partisipan media dan khalayak, memicu reaksi emosional serta memengaruhi persepsi publik. Dalam konteks praktik sosial budaya, film dokumenter tersebut merefleksikan norma masyarakat Indonesia serta mendorong diskusi tentang keadilan dan peran media dalam membentuk realitas sosial.
Ketidaksesuaian Materi dan Asesmen pada Pembelajaran Bahasa Indonesia Teks Negosiasi
Authors: Alfiani Celvin Reindira , Rani Abdul , Wahyuni Sri 
Published: October 2024

Penggunaan instrumen asesmen yang tidak tepat berpotensi besar menghambat efektivitas dan menurunkan kualitas pembelajaran. Memastikan kesesuaian antara materi dan asesmen menjadi hal yang penting dalam menciptakan pembelajaran yang optimal. Penelitian ini bertujuan untuk menganalisis ketidaksesuaian materi teks negoisasi dan asessmen serta mengidentifikasi solusi optimalisasi pembelajaran pada materi tersebut. Pendekatan penelitian menggunakan kualitatif deskriptif. Proses pengumpulan data dilakukan dengan cara observasi dan wawancara kepada 1 guru bahasa Indonesia dan 6 siswa kelas X di SMK Al-Hakim. Hasil penelitian menunjukkan adanya ketidaksesuaian antara materi teks negoisasi dan asesmen yang digunakan oleh guru terutama dalam menilai keterampilan berbicara. Dalam pembelajaran, guru hanya menggunakan asesmen formatif atau kognitif berupa soal tertulis. Asesmen formatif yang digunakan oleh guru kurang sesuai untuk materi teks negoisasi karena sifatnya yang cenderung statis, tidak interaktif dan tidak autentik. Padahal secara penerapan, negoisasi membutuhkan kemampuan yang nyata terutama dalam menanggapi situasi sosial yang dinamis. Latihan soal dan tayangan video tentang negoisasi hanya akan membuat siswa paham secara konseptual yang sifatnya sementara. Hal ini berimbas pada rendahnya kompetensi siswa terutama pada keterampilan berbicara. Pembelajaran berbasis pengalaman seperti praktek dan project sangat dibutuhkan guna meningkatkan pemahaman tentang negoisasi. Pembelajaran yang faktual, implikatif dan interaktif juga penting untuk diterapkan agar keterampilan berbicara siswa dapat lebih maksimal.
EXAMINING THE IMPACT OF VALUE ADDED TAX ON SUKUK YIELD: A REVIEW
Authors: Al-Otaibi Mohammed Ibrahim , Mohd Nor Normaziah , Yusri Yusniyati 
Published: October 2024

This study aims to explore the impact of VAT (Value Added Tax) on Sukuk market in Saudi Arabia. A systematic literature review was used to answer a clearly formulated question regarding the impact of VAT on Sukuk market. The papers author included met the following key selection criteria: 1) published in peer-reviewed journals, 2) written in English, 3) focus on only impact of VAT on Sukuk market; and 4) published from January 2010 to September 2022. Initially, a total of 1,943 articles were identified from which only 8 papers were included in this study which fulfil the inclusion and exclusion criteria. From the selected articles there was mounting evidence that there is further study required for understanding the VAT impact on Sukuk market around the world and particularly in the Kingdom of Saudi Arabia because the VAT introduces in January 2018. Furthermore, more investigation is also needed in VAT and its impact on Sukuk market in Saudi Arabia especially for achieving national development plan Vision 2030. Moreover, green Sukuk also play important role in the social and economic development of a country and more such infrastructural investment is needed.
Abstrak: Penelitian ini bertujuan untuk mengeksplorasi dampak PPN (Pajak Pertambahan Nilai) terhadap pasar Sukuk di Arab Saudi. Tinjauan literatur sistematis digunakan untuk menjawab pertanyaan yang dirumuskan dengan jelas mengenai dampak PPN terhadap pasar Sukuk. Makalah yang disertakan penulis memenuhi kriteria pemilihan utama berikut: 1) diterbitkan dalam jurnal peer-review, 2) ditulis dalam bahasa Inggris, 3) hanya berfokus pada dampak PPN pada pasar Sukuk; dan 4) diterbitkan dari Januari 2010 hingga September 2022. Awalnya, total 1.943 artikel diidentifikasi di mana hanya 8 makalah yang dimasukkan dalam penelitian ini yang memenuhi kriteria inklusi dan eksklusi. Dari artikel yang dipilih, ada bukti yang meningkat bahwa ada studi lebih lanjut yang diperlukan untuk memahami dampak PPN pada pasar Sukuk di seluruh dunia dan khususnya di Kerajaan Arab Saudi karena PPN diperkenalkan pada Januari 2018. Selanjutnya, diperlukan juga penyelidikan lebih lanjut dalam PPN dan dampaknya terhadap pasar Sukuk di Arab Saudi terutama untuk pencapaian rencana pembangunan nasional Visi 2030. Selain itu, Sukuk hijau juga memainkan peran penting dalam pembangunan sosial dan ekonomi suatu negara dan lebih banyak lagi diperlukan investasi infrastruktur seperti itu.
Kata Kunci: Arab Saudi, Sukuk, Instrumen keuangan, Pajak Pertambahan Nilai, Tinjauan Sistematis
Dinamizando la gestión del conocimiento a través de mapas de conocimiento: un análisis desde los beneficios y las dificultades
Authors: Jurado-Zambrano Diego Armando , Echeverrri Hoyos Isabel Cristina 
Published: October 2024

Objetivo: identificar los beneficios y las dificultades experimentadas en la implementación de la herramienta de mapas de conocimiento en una organización del sector público colombiano.
Diseño/metodología: el estudio se desarrolló bajo una metodología cualitativa de alcance descriptivo. Se empleó la estrategia de estudio de caso único y la herramienta de entrevista semiestructurada.
Resultados: los resultados mostraron que los mapas de conocimiento han ayudado a estandarizar los procesos y a dar continuidad al desarrollo de estos, a identificar conocimientos críticos, a acelerar la curva de aprendizaje y a facilitar la transferencia de conocimiento. Por su parte, las dificultades se relacionan elevada rotación de personal, la falta de empoderamiento, los cambios periódicos del personal directivo y la falta de un equipo técnico sólido para acompañar el despliegue de los mapas de conocimiento.
Conclusiones: los mapas de conocimiento son una herramienta valiosa en los procesos de gestión del conocimiento, principalmente en la identificación de conocimientos críticos para la operación. Sin embargo, condiciones propias de organizaciones del sector público, tales como la forma de administrar el talento humano y la alta rigidez administrativa, puede llevar a estas a enfrentar obstáculos que impidan implementar estrategias efectivas para la gestión del conocimiento.
Originalidad: el estudio explora la implementación de los mapas de conocimiento en una organización pública, aspecto poco teorizado en este sector. En Colombia, las normativas en el área son relativamente recientes. Por consiguiente, estos resultados ofrecen a los responsables de la toma de decisiones una mejor comprensión de los aspectos clave que deben tenerse en cuenta a la hora de aplicar estas estrategias.
Atividades educativas em saúde na escola: implementando a atenção primária à saúde para mitigar focos da dengue
Authors: Antunes Batista Jack Eduarda , Pereira de Oliveira Mirian , De Oliveira Silva Anita 
Published: October 2024

Resumo
O objetivo é informar crianças matriculadas em uma rede de ensino pública a respeito dos cuidados para o combate à dengue, utilizando metodologia lúdica e educativa. Trata-se de um estudo de natureza descritiva e qualitativa, caracterizado como um relato de experiência. Foi realizada uma ação de educação em saúde para o controle da proliferação do vetor Aedes Aegypti com crianças de até 5 anos matriculadas em uma Escola Municipal de Educação Infantil, localizada em uma comunidade de Belo Horizonte (MG), entre maio e junho de 2023. Após a atividade, a maioria das crianças demonstrou conhecimento insuficiente sobre o tema. Houve participação efetiva e interesse delas nas atividades. Ao final, os desenhos ilustraram possíveis criadouros do vetor encontrados em casa e o sintoma mais característico da doença, indicando uma compreensão do conteúdo. É válido ressaltar que, os desenhos que mais representaram aprendizagem da temática foram feitos por crianças maiores (com idades próximas ou iguais à cinco anos), por estarem e um estágio de desenvolvimento cognitivo e biológico maior em comparação às crianças menores. Por fim, destaca-se a relevância das abordagens educativas em formato lúdico para propagar informações sobre saúde e garantir a promoção da conscientização infantil.

Palavras-chave: Educação em Saúde; Dengue; Atenção Primária à Saúde