bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of NRAMP1 Gene Polymorphism with Hemoglobin and Iron Parameters in Patients with β-Thalassemia Major
Authors: Nahi Sameh M. , Jabir Ferdous A. 
Published: September 2024

Abstract

BACKGROUND:
Thalassemia is an inherited disorder that is also called mediterranean anemia and is described by a lack of hemoglobin synthesis. β-thalassemia is more common in people of certain origins, particularly those from the Mediterranean region and Arabian Peninsula. The NRAMP1 protein in membranes catalyzes the exit of divalent metal ions from phagolysosomes and their entry into the cytoplasm, including iron and manganese.

AIMS:
To investigate the possible link between beta-thalassemia major (β-TM) illness and the single-nucleotide polymorphism (3′ untranslated region) rs3 of the NRAMP1 gene.

MATERIALS AND METHODS:
To investigate the relationship between the condition β-TM and the NRAMP1 gene, the study used restriction fragment length polymorphisms-polymerase chain reaction. The enzyme-linked fluorescent assay was used to quantify the ferritin level. A hematology analyzer was used to quantify hemoglobin concentration. A spectrophotometer technique was used to assess the serum iron, serum total iron-binding capacity (TIBC), and serum unsaturated iron-binding capacity.

RESULTS:
The results showed a difference in hemoglobin and serum iron levels, serum unbound iron-binding capacity, serum TIBC, and ferritin concentration between individuals suffering from β-thalassemia and healthy groups. In NRAMP1 gene polymorphism, a highly significant difference was observed between the distribution of two alleles (TG− 244 bp, and TG+ 211 bp).

CONCLUSION:
During an investigation of NRAMP1 gene polymorphism, a significant variance was observed between β-thalassemia and control groups. Those who carried the (244 bp −TG) allele were found to have a 3.6 times higher risk of developing complications of β-TM than those who carried the (211 bp −TG+) allele.
Blood Donor Characteristics at a Hospital Blood Bank in Saudi Arabia: A Trend-analysis
Authors: Almalki Daee , Badawi Maha A. , Elgemmezi Tarek , Alabdali Ahmad , Almutairi Meznah , Almogbel Alhanouf , Hindawi Salwa 
Published: September 2024

Abstract

BACKGROUND:
Identification of blood donor profiles helps with recruitment and retention strategies.

OBJECTIVES:
To describe donor characteristics at a hospital blood bank and to describe any changes in donor characteristics throughout the study period.

METHODS:
In this retrospective observational study, we reviewed the blood bank records from 2005 to 2022. Characteristics of donors (age 18 or above) were collected. Percentages of donors according to various characteristics were described in 3-year intervals and compared using the Chi-square test.

RESULTS:
Over the study period, 226,576 blood donations were identified. Most donors were men, and half were non-Saudi nationals. Approximately two-thirds of the blood donors (145,794, 64.3%) were between 25 and 44 years old, and (59,650, 26.3%) were between 18 and 24 years old. When donors were compared across time intervals according to the age group, the percentage of donors 18–24 years old decreased over time from 31.4% in the interval 2005–2007 to 23.5% in the 2020–2022 interval. Significant changes were seen in the percentages of repeat donors as well.

CONCLUSIONS:
Donation trends showed significant changes related to donor age, gender, and nationality as well as donor type (new or repeat donor), the most notable being that donations by younger adults have decreased. Marketing plans must be implemented to target and retain this donor population. Further research is required for the detailed characterization of donors across the country to ensure the sustainability of the blood supply.
A Case-Control Study Examining the Relationship between Gastroesophageal Reflux Disease and Dental Caries
Authors: Suganya P , Nimmy P , Savitha S , Srutheesri R. P. , Anita M , Dhanushkodi Charumathi , Raghavan Savitha Lakshmi 
Published: September 2024

ABSTRACT

Aim:
This case-control study aims to assess the association between gastroesophageal reflux disease (GERD) and dental caries among individuals aged 18–35 years in Chennai city, India.

Materials and Method:
The study included 350 participants, divided equally into GERD and non-GERD groups, identified using a six-item GERD questionnaire. Dental caries was assessed using the DMFT index, and the body mass index (BMI) was calculated for each participant. The collected data were analyzed using analysis of variance.

Results:
Significant association was found between GERD and higher DMFT scores, with GERD patients exhibiting more decayed, missing, and total teeth compared to non-GERD patients.

Conclusion:
These findings underscore the need for integrated dental and medical care for GERD patients, emphasizing weight management to mitigate GERD symptoms. The study provides valuable insights into the interplay between GERD, dental caries, and BMI in a young adult population.
Laminar Architecture and Morphometry of Developing Human Fetal Cerebellum
Authors: Ahmad Nadia , Singh Deepa , Jethani Sunder Lal 
Published: September 2024

Abstract

Background:
One of the organs in the human fetus that starts to differentiate extremely early and keeps doing so throughout the postnatal period is the cerebellum. The goal of this study was to create a nomogram using the chronological events that were occurring and the relationship with progressing gestational age. Granule cells and Purkinje cells play a crucial role in the normal development of the cerebellum. Any disruption at the cellular level can lead to abnormal migration of these cells, potentially resulting in hypoplasia of the cerebellar vermis.

Methodology:
Tissue specimens from 60 human fetuses were studied for histological changes after being grouped into four from 13th week to 32nd week. Fetuses with any neurological deficit were excluded from the study. Different layers were identified, and the thickness of each layer was noted.

Results:
The first two groups had three layers, but the composition was different in both. The marginal and mantle layers in the second group disappeared completely. The third group showed presence of five layers, with addition of lamina dissecans, appearing for a transient period. The fourth group had four layers. The thickness of external granular layer and internal granular layer (IGL) increased throughout, except that the IGL made an appearance from the second group only. Lamina dissecans appeared, causing a significant shift between 23 and 27 weeks. The fetus has a four-layered structure near term, with an external granular layer persisting throughout the early postnatal stage of life. Progression of pregnancy was positively connected with the molecular and Purkinje cell layer (PCL) thickness.

Conclusion:
Progression of pregnancy was positively connected with the molecular and PCL thickness. Age determination and neuropsychiatric disorders of the developing fetus may benefit from such a link.
Economic Evaluation of Using Different Water Sources in the culture of African Catfish (Clarias gariepinus; Burchell, 1822) at Ediba-Qua, Calabar, Cross River State, Nigeria
Authors: Ayim E. M. , Isah M. H. , Ukorebi E. A. 
Published: September 2024

The objective of this paper is to evaluate the economic use of different water sources in the culture of the African Catfish (Clarias gariepinus; Burchell 1822) at Ediba-Qua, Calabar, Cross River State, Nigeria using standard appropriate techniques. Results obtained showed that cost of feeding increased significantly at (p < 0.05) with growth rate and weight gain in fish reared in borehole water having the highest cost (₦ 21617.86 ± 31.77) and least in rainwater (₦ 13635.93 ± 48.16). Profit index was highest in C. gariepinus reared in borehole water (16.99 ± 0.70), and least in stream water (15.74 ± 0.42) indicating that borehole water is the best water source for C. gariepinus with regards to profitability. This study has shown that fish farmers and fish intending farmers who are challenged by borehole water supply for fish culture can alternatively harvest rainwater or collect stream water to rear fish that could be utilized at a subsistent level.
Heavy Metal Levels in Insect Species Collected from Enyigba Community with Mining Activities in Southeast Nigeria
Authors: Nwanchor M. C. , Akunne C. E. , Uhuo C. A. , Ononye B. U. , Onyekwere A. M. , Anyanwu I. N. 
Published: September 2024

Insects are the largest and most diverse group of organisms which are typically the overwhelming dominant invertebrate faunal group extensively used in biomonitoring and bioassessment. The aim of this paper was to evaluate the heavy metals levels in insect species collected from Enyigba Community with mining activities in Southeast Nigeria using appropriate standard methods. In this study, three sites namely: Upper Inyia-(SA), Lower Inyia (SB) and the Control Site (SC) were selected and insect specimens were collected and evaluated from July 2022 to February, 2023. The insect groups used were Reticulitermes flavipes (termite), Zonocerus elegans (grasshopper), Acraea acrita (butterfly) and Cremtogaster sp. (Ant). The selected insects’ samples were analyzed using atomic absorption spectrophotometer (AAS). The results showed heavy metal accumulations on the selected insects particularly the toxic metals such as Cadmium (Cd), Copper (Cu), Manganese (Mn) and Mercury (Hg). Insects examined were Reticulitermes flavipes, Zonocerus elegans, Acraea acrita, and Crematogaster sp. collected from Enyigba mines. High concentrations of Cd was recorded in Zonocerus elegans at SA (0.13±0.042) and SB (0.17±0.007) which is far above WHO/FAO permissible limit. The result further revealed that there was also high Cd concentration (0.21±0.011) in Reticulitermes flavipes, which is also far above WHO/FAO permissible limit. Grasshopper, termites and butterfly had the highest accumulation of heavy metals among the studied insect groups, highlighting the challenges of mining on agriculture and food security in the region.
Financial requisition system: adopting agile techniques in solving corporate financial management challenge
Authors: Cole M. A. , Baridam B. B. 
Published: September 2024

This paper addresses a longstanding problem in corporate financial management by introducing a financial requisition system (FRS) using the Agile software programming methodology. While various branches of financial management, including procurement, have evolved their requisition processes, the financial requisition process has lagged in efficiency and transparency. Recognizing this gap, this paper focuses on developing an advanced tool specifically tailored to the financial requisition as an aspect of the financial management system. The proposed financial requisition system integrates user-friendly interfaces and robust backend functionalities, acknowledging the unique complexities of financial requisitions. By learning from the evolution of other branches of financial management, this paper aims to adopt agile transparency, and establish an advanced framework for managing financial needs. The paper contributes to the evolution of financial requisition processes, providing stakeholders and indeed all players in the financial industry with a dedicated and effective solution for managing financial workflows.
Megtartás-menedzsment sajátosságai hazai kutatási tapasztalatok tükrében
Authors: Szopos Edina-Cecília 
Published: September 2024

Recent changes, both in the macro and micro environment, have challenged organisations in recruiting and retaining staff. The aim of this paper is to explore and analyse the key factors that affect staff retention. It also aims to explore the specificities of the domestic labour market and the retention management practices of companies. In order to identify and collect these factors, I conducted a systematic literature review in Google Scholar, MTMT, Web of Science and the Online Encyclopedia of Public Service databases, examining studies published between 2020. and 2023. Based on the research findings, I believe that prioritizing the well-being of employees is key to workforce retention. It is important to create a constructive, supportive work environment where employees can enjoy their work and feel valued and well treated. They should also receive regular feedback on their work, feel satisfied with the working environment, and have the opportunity to work as part of a team, develop professionally and have opportunities for career progression.
Applying Machine Learning to Big Data Analysis in Economics
Authors: Бойдаченко В.В. , Бутин П.А. , Семененко А.В. , Косникова О.В. 
Published: September 2024

В статье изучается тема машинного обучения, а именно рассматриваются принципы работы машинного обучения и его применение для обработки информации в экономической сфере. Анализируются основные методы машинного обучения и работы с большими данными. В статье применяется алгоритм обработки производственных данных. Выявлены плюсы и минусы машинного обучения и других методов обработки информации и выделены возможные способы оптимизации данного алгоритма.
This article studies the topic of machine learning, namely, the principles of machine learning and its application to information processing in the economic sphere. Examples of successful implementation of machine learning methods in various sectors of the economy are also considered, which demonstrates their potential for improving business processes and making informed management decisions. The main methods of MO working with big data are analyzed. The article uses an algorithm for processing production data, its need for use and possible applications. Thanks to this study, the pros and cons of MO and other information processing methods were identified and possible optimizations of this algorithm were highlighted.
Features of digital marketing in Russia
Authors: Кадитлаева Н.Л. , Нажмутдинова С.А. 
Published: September 2024

В статье анализируется современная роль цифрового маркетинга. Цифровая среда все больше внедряется в жизнь современных потребителей, что способствует появлению новых инструментов в каждом из элементов комплекса продвижения. Перечислены факторы, повлиявшие на цифровые изменения инструментов продвижения. Важное место отводится рассмотрению возможных препятствий при переходе к маркетингу роста, а также их возможным решениям.
This publication analyzes the modern role of digital marketing. The digital environment is increasingly being introduced into the lives of modern consumers, and this contributes to the emergence of new tools in each element of the promotion mix. The factors that influenced digital changes in promotion tools are listed. An important place in the article is given to the consideration of possible obstacles in the transition to growth marketing, as well as their possible solutions.
The impact of diversification on the balance of cash flows of an engineering organization
Authors: Кислицына Л.В. 
Published: September 2024

Сбалансированность денежных потоков как одна из ключевых целей любой компании может быть достигнута различным образом. Одним из действенных механизмов ее реализации является диверсификация деятельности. Для инжиниринговых организаций, отличающихся спецификой деятельности, диверсификация в данном случае имеет особое значение. Она позволяет не только балансировать денежные потоки, но и способствует укреплению финансового состояния в части ликвидности и финансовой результативности. Содержание настоящей статьи может представлять интерес для практических работников в сфере инжиниринга, а также для обучающихся экономических направлений подготовки.
Balancing cash flows as one of the key goals of any company can be achieved in various ways. One of the effective mechanisms for its implementation is diversification of activities. For engineering organizations that differ in the specifics of their activities, diversification in this case is of particular importance. It allows not only to balance cash flows, but also helps to strengthen the financial condition in terms of liquidity and financial performance. The content of this article may be of interest to practitioners in the field of engineering, as well as to students of economic areas of training.
Portfolio risk-management effectiveness improvement: comparative study of different approaches
Authors: Никулин М.В. 
Published: September 2024

В статье предлагается концепция эффективного управления портфельными рисками и распределения капитала. Понимая риски, связанные с каждым активом, можно минимизировать общий риск портфеля, систематически диверсифицируя распределение капитала. Для достижения этой цели предлагается сочетать оценку стоимости-под-риском (VaR) с другими статистическими показателями, такими как процентильное ранжирование и эмпирическая закономерность. Такая комбинация может значительно снизить потенциальные потери по портфелю по сравнению с портфелем, в котором активы распределены равномерно. Результаты основаны на анализе цен активов с использованием трех различных методов: исторического (непараметрического), дисперсионно-ковариационного (параметрического) и метода Монте-Карло.
The article proposes the concept of effective portfolio risk management and capital allocation. By understanding the risks associated with each asset, it is possible to minimize the overall risk of the portfolio by systematically diversifying the allocation of capital. To achieve this goal, it is proposed to combine the value-at-risk (VaR) assessment with other statistical indicators such as percentile ranking and empirical rule. This combination can significantly reduce potential portfolio losses compared to a portfolio in which assets are evenly distributed. The results are based on the analysis of asset prices using three different methods: historical (nonparametric), variance-covariance (parametric) and the Monte Carlo method.
Innovative marketing approaches in the sports nutrition market
Authors: Антошина К.А. , Мартынюк Я.П. 
Published: September 2024

Статья посвящена всестороннему анализу инновационных маркетинговых подходов, применяемых на рынке спортивного питания. Обоснована актуальность выбранной научной проблематики в условиях растущей конкуренции и стремительного развития рынка спортивного питания. Особое внимание уделено детальному изучению современных публикаций по данной теме, что позволило выявить наиболее значимые исследования, направленные на передачу и использование научного опыта в данной области. Рассмотрены ключевые элементы структуры инновационных маркетинговых подходов, их инструменты, а также оценены их эффективность и возможности применения для повышения конкурентоспособности на рынке спортивного питания. В заключение обозначены перспективные направления дальнейших исследований, направленных на улучшение маркетинговых стратегий и их адаптацию к изменяющимся требованиям потребителей и рынка в целом.
The article is devoted to a comprehensive analysis of innovative marketing approaches used in the sports nutrition market. The relevance of the chosen scientific problem is substantiated in the context of growing competition and the rapid development of the sports nutrition market. Special attention is paid to a detailed study of modern publications on this topic, which made it possible to identify the most significant studies aimed at transferring and using scientific experience in this field. The key elements of the structure of innovative marketing approaches, their tools are considered, as well as their effectiveness and application possibilities for increasing competitiveness in the sports nutrition market are evaluated. In conclusion, promising areas of further research aimed at improving marketing strategies and adapting them to the changing requirements of consumers and the market as a whole are outlined.
Social networks as an effective marketing tool in the field of public health
Authors: Конюшков А.А. , Власова Т.И. 
Published: September 2024

В статье рассмотрены форматы взаимодействия государственных медицинских организаций с потребителями медицинских услуг в Московской области в части формальных и неформальных каналов связи, а также проанализирован эффект от последних. Доказано, что активное взаимодействие с потребителями услуг государственных медицинских организаций по неформальным каналам связи, таким как социальные сети, способствует повышению уровня удовлетворенности пациентов, снижению количества официальных обращений и повышению качества оказываемой медицинской помощи населению, а также позволяет формировать положительный имидж медицинской организации, оперативно реагировать на обратную связь и принимать системные решения на уровне медицинской организации. Предложенные рекомендации по взаимодействию с потребителями услуг государственных медицинских организаций посредством неформальных каналов связи способствуют повышению уровня удовлетворенности пациентов, снижению количества официальных обращений и повышению качества оказываемой медицинской помощи населению.
The article examines the formats of interaction between state medical organizations and consumers of medical services in the Moscow region in terms of formal and informal communication channels, and analyzes the effect of the latter. It is proved that active interaction with consumers of services of public medical organizations through informal communication channels, such as social networks, helps to increase patient satisfaction, reduce the number of official appeals and improve the quality of medical care provided to the population, and also allows you to form a positive image of a medical organization, promptly respond to feedback and make systemic decisions at the medical level organizations. The proposed recommendations on interaction with consumers of services of public medical organizations through informal communication channels contribute to increasing patient satisfaction, reducing the number of official requests and improving the quality of medical care provided to the population.
Forms of outsourcing as a tool for the development of the region’s economy
Authors: Тымчина Л.И. 
Published: September 2024

В статье рассмотрены вопросы актуальности внедрения аутсорсинга и рассмотрено его влияние на развитие региона. Результаты анализа преимуществ и недостатков выделенных подходов к пониманию сущности аутсорсинговых услуг и современных тенденций развития экономики позволили выделить формы аутсорсинга (управленческий, операционный и сопутствующий) с акцентом на наиболее характерные услуги в рамках каждой из них, вследствие чего обосновано их значение для инновационного развития региона.
The article discusses the relevance of outsourcing implementation and examines its impact on the development of the region. The results of the analysis of the advantages and disadvantages of the highlighted approaches to understanding the essence of outsourcing services and current trends in economic development allowed us to identify the forms of outsourcing (managerial, operational and related) with an emphasis on the most characteristic services within each of them, as a result of which their importance for the innovative development of the region is justified.