bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the potential of the extract of Perilla sp. as a natural insecticide for Bemisia tabaci (Hemiptera: Aleyrodidae) on sweet peppers
Authors: Kim Soowan , Jung Minhyung , Song Yoon‐Jae , Kang Se Chan , Kim BaeYong , Choi I‐Jin , Kim Hong Geun , Lee Doo‐Hyung 
Published: February 2017

AbstractThe sweetpotato whitefly, Bemisia tabaci Gennadius (Hemiptera: Aleyrodidae), is a major pest on greenhouse crops including sweet pepper (Capsicum annuum L.), which is one of the leading greenhouse crops in South Korea. Synthetic insecticides, especially the neonicotinoids, have been used to conventionally control this pest. There have been continuous efforts to develop plant‐derived compounds as insecticides, deterrents, and repellents to reduce spraying synthetic insecticides. To develop new plant‐extract insecticides, we investigated the insecticidal effects of Perilla sp. (Perilla frutescens var. crispa) extract on B. tabaci in laboratory conditions. The Perilla sp. extract induced 90 % mortality within one hour, but phytotoxicity symptoms on sweet pepper leaves were also observed. We monitored the population change and spatial distribution of adult B. tabaci in an experimental sweet pepper greenhouse using yellow sticky traps, and analyzed distribution patterns by spatial analysis with distance indices (SADIE). Based on monitoring data and SADIE analysis, we concluded that B. tabaci aggregated near the greenhouse entrances, and it showed aggregation and association pattern as time passed. Therefore, we recommend spraying Perilla sp. extract near the entrances or wild host before the pest population penetrates. It will be one of the alternative pest management strategies to reduce B. tabaci population with fewer negative effects from chemical insecticide. Further study is required to reduce the phytotoxicity symptoms from Perilla sp. extract spray and insecticidal effect should be evaluated under field conditions.
Enterprise Risk Management and the Financial Reporting Process: The Experiences of Audit Committee Members, CFOs, and External Auditors
Authors: Cohen Jeffrey , Krishnamoorthy Ganesh , Wright Arnold 
Published: February 2017

AbstractThe recent financial crisis has brought to the forefront the need for companies to effectively manage their risks. In this regard, one approach that has gained prominence is enterprise risk management (ERM). Importantly, little is known about the link between ERM and the financial reporting process. This link is critical, because it is imperative that financial reporting adequately depicts the financial status (e.g., valuations, estimates) and associated risks of a company as revealed by ERM. Additionally, from an auditing perspective, ERM affects the risks of misstatement, which should impact audit planning. Accordingly, the objective of this study is to examine the experiences of audit partners, CFOs, and audit committee (AC) members (“the governance triad”) on the link between ERM and the financial reporting process. To determine whether members of the governance triad focus on monitoring, strategy, or both, we also examine their definition of and experiences with ERM with respect to agency and/or resource dependence theory. To address these issues, we conduct semistructured interviews of experienced individuals that form the governance triads from 11 public companies. There are three major findings from our study. First, importantly, all three types of participants see a strong link between ERM and the financial reporting process. Second, despite recognition of the broad nature of ERM, the predominant experiences of the actual roles played by triad members center on agency theory, while resource dependence may be relatively underemphasized by all triad members. Finally, CFOs and AC members indicate that auditors may be especially underutilizing ERM in the audit process, suggesting an “expectations gap.”
Melanoma and pregnancy
Authors: Morton Sarah Kym , Morton Adam Park 
Published: February 2017

AbstractMelanoma is the most common cancer in women during their reproductive years and kills more young Australians than any other single cancer. Care of women whose pregnancy is complicated by a diagnosis of malignancy is complex. The risk of delaying treatment to the mother, the short‐term and long‐term risks of premature delivery to the child, and the immediate risks to the foetus and long‐term risks to the child of maternal treatment with surgery, radiotherapy or medical therapies must be considered.
Lnc‐DC mediates the over‐maturation of decidual dendritic cells and induces the increase in Th1 cells in preeclampsia
Authors: Zhang Wen , Zhou Yang , Ding YiLing 
Published: February 2017

ProblemPreeclampsia is a severe pregnancy‐related disease that involves an imbalance of the immune reaction, which is dominated by T helper1 (Th1) cells; however, the mechanism is unclear.Method of StudyWe used flow cytometry, RT‐PCR and western blotting to detect Th1 cells in the blood and mature dendritic cells, lnc‐DC (a long non‐coding RNA that is specifically expressed in DCs and can mediate dendritic cell maturation by phosphorylating STAT3) and p‐STAT3 (phosphorylated transducer and activator of transcription 3) in the deciduas of normal pregnancies and preeclampsia patients.ResultsWe found that the expression of lnc‐DC and p‐STAT3 was increased in the deciduas of preeclampsia patients. The proportion of Th1 cells and mature dendritic cells was significantly higher in the preeclampsia patients.ConclusionThese results suggested the hypothesis that the overexpression of lnc‐DCs induces the over‐maturation of decidual dendritic cells in preeclampsia patients and leads to an increase in Th1 cells.
Survey of patient and partner satisfaction following collagenase Clostridium histolyticum treatment for Peyronie's disease
Authors: Anaissie J. , Yafi F. A. , Traore E. J. , Sikka S. C. , Hellstrom W. J. G. 
Published: February 2017

SummaryIntralesional injection of collagenase Clostridium histolyticum (CCH) is a minimally invasive, Food and Drug Administration‐approved, effective treatment for Peyronie's disease (PD). To assess the satisfaction of patients and their female sexual partners (FSP) following CCH therapy for PD, we conducted a retrospective review of the records of all patients treated with CCH for PD between 04/2014 and 03/2016. Collected variables included demographics, pre‐ and post‐treatment sexual function, penile curvature, penile vascular findings, and treatment outcomes. Patients and their FSPs were subsequently contacted by telephone and queried regarding their ability to have intercourse and their satisfaction with treatment. A total of 24 couples responded to our questionnaire and constitute the subjects of this analysis. Patient and FSP satisfaction with treatment were 67% and 71%, respectively. Significant predictors of FSP satisfaction with treatment included recall of penile trauma during prior sexual intercourse, improved ability to have sexual intercourse following treatment, and absence of post‐procedural glans hypoesthesia. In conclusion, CCH imparts a significant benefit on a couple's sexual health. Partner satisfaction with treatment is correlated with improved ability to have sexual intercourse and absence of patient glans hypoesthesia.
Extreme spermatogenesis failure: andrological phenotype and intracytoplasmic sperm injection outcomes
Authors: Plouvier P. , Barbotin A.‐L. , Boitrelle F. , Dewailly D. , Mitchell V. , Rigot J.‐M. , Lefebvre‐Khalil V. , Robin G. 
Published: February 2017

SummaryPatients with very low sperm count through direct sperm examination can exhibit extreme oligozoospermia or cryptozoospermia (after centrifugation). The management of these patients is a real challenge for both clinicians and biologists. In this retrospective and comparative cohort study, we compared the andrological phenotype of patients with extreme alterations of spermatogenesis and assessed whether the origin of spermatozoa (testicular or ejaculate) had any influence on intracytoplasmic sperm injection (ICSI) outcomes. A total of 161 ICSI cycles were performed using ejaculated spermatozoa from 75 patients with extreme oligozoospermia (EOS) or cryptozoospermia (CS) and 150 ICSI cycles using extracted testicular spermatozoa from 74 patients with non‐obstructive azoospermia (NOA). Physical, hormonal, ultrasound assessments, and ICSI outcomes were performed in each group. Cryptorchidism was significantly more frequent in the NOA group (60.8% vs. 22.6%, p = 0.001). FSH levels were significantly higher [18.9 IU/L (5.9–27.0) vs. 15.3 IU/L (9.0–46.5), p = 0.001] and the majority of inhibin B levels measured were found mostly undetectable in the NOA group as compared to EOS/CS group (31.1% vs. 10.7%, p = 0.0004). Moreover, we found no significant differences in the respect to the fertilization rates (48.9% and 43.3%, p = 0.43), implantation rates (17.4% and 15.9%, p = 0.77), and percentage of top quality embryo (22.4% and 20.4%, p = 0.73) between the two groups. The clinical pregnancy rates per embryo transferred were comparable in both groups (28.3% and 27.4%, p = 0.89). In this study, we showed for the first time a different andrological phenotype between EOS/CS and NOA groups. Indeed, cryptorchidism was significantly more frequent with more severe endocrine parameters found in the NOA group. These results reflect a more profound alteration in spermatogenesis in NOA patients. However, there was no difference in ICSI outcomes between NOA and EOS/CS groups.
Review article: pathogenesis and clinical manifestations of gastrointestinal involvement in systemic sclerosis
Authors: Kumar S. , Singh J. , Rattan S. , DiMarino A. J. , Cohen S. , Jimenez S. A. 
Published: February 2017

SummaryBackgroundGastrointestinal tract (GIT) involvement is a common cause of debilitating symptoms in patients with systemic sclerosis (SSc). There are no disease modifying therapies for this condition and the treatment remains symptomatic, largely owing to the lack of a clear understanding of its pathogenesis.AimsTo investigate novel aspects of the pathogenesis of gastrointestinal involvement in SSc. To summarise existing knowledge regarding the cardinal clinical gastrointestinal manifestations of SSc and its pathogenesis, emphasising recent investigations that may be valuable in identifying potentially novel therapeutic targets.MethodsElectronic (PubMed/Medline) and manual Google search.ResultsThe GIT is the most common internal organ involved in SSc. Any part of the GIT from the mouth to the anus can be affected. There is substantial variability in clinical manifestations and disease course and symptoms are nonspecific and overlapping for a particular anatomical site. Gastrointestinal involvement can occur in the absence of cutaneous disease. Up to 8% of SSc patients develop severe GIT symptoms. This subset of patients display increased mortality with only 15% survival at 9 years. Dysmotiity of the GIT causes the majority of symptoms. Recent investigations have identified a novel mechanism in the pathogenesis of GIT dysmotility mediated by functional anti‐muscarinic receptor autoantibodies.ConclusionsDespite extensive investigation, the pathogenesis of gastrointestinal involvement in systemic sclerosis remains elusive. Although treatment currently remains symptomatic, an improved understanding of novel pathogenic mechanisms may allow the development of potentially highly effective approaches including intravenous immunoglobulin and microRNA based therapeutic interventions.
Feed degradability, rumen fermentation and blood metabolites in response to essential oil addition to fistulated non‐lactating dairy cow diets
Authors: Suksombat Wisitiporn , Nanon Atitthan , Meeprom Chayapol , Lounglawan Pipat 
Published: February 2017

AbstractThe effects of essential oils (EOs) on ruminal nutrient disappearance, rumen fermentation and blood metabolites in fistulated non‐lactating dairy cows were studied. Four fistulated non‐lactaing dairy cows were used in a 4 × 4 Latin square design; the experiment consisted of four periods of 21 days in each period, with the first 14 days for adaptation followed by 7 days of measurement period. Animals were fed 3 kg/day of 21% crude protein (CP) concentrate and ad libitum corn silage. Treatments were: (i) control; (ii) 2 mL Allicin/cow/day; (iii) 2 mL zingiberene/cow/day; and (iv) 2 mL citral/cow/day. The results demonstrated that EOs increased dry matter and neutral detergent fiber degradabilities at 48 and 72 h, but had no effect on acid detergent fiber and CP degradabilities. EOs did not change ruminal pH, ammonia nitrogen, protozoa, volatile fatty acid concentrations and blood glucose but reduced blood urea nitrogen at 4 h.
Clarithromycin, trimethoprim, and penicillin and oxidative nucleic acid modifications in humans: randomised, controlled trials
Authors: Larsen Emil List , Cejvanovic Vanja , Kjær Laura Kofoed , Pedersen Morten Thorup , Popik Sara Daugaard , Hansen Lina Kallehave , Andersen Jon Trærup , Jimenez‐Solem Espen , Broedbaek Kasper , Petersen Morten , Weimann Allan , Henriksen Trine , Lykkesfeldt Jens , Torp‐Pedersen Christian , Poulsen Henrik Enghusen 
Published: February 2017

AimsIn vitro studies have demonstrated that formation of reactive oxygen species (ROS) contributes to the effect of bactericidal antibiotics. The formation of ROS is not restricted to bacteria, but also occurs in mammalian cells. Oxidative stress is linked to several diseases. This study investigates whether antibiotic drugs induce oxidative stress in healthy humans as a possible mechanism for adverse reactions to the antibiotic drugs.MethodsThis study contains information from two randomised, controlled trials. Participants underwent 1 week treatment with clarithromycin, trimethoprim, phenoxymethylpenicillin (penicillin V), or placebo. Oxidative modifications were measured as 24‐h urinary excretion of 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine (8‐oxodG) and 8‐oxo‐7,8‐dihydroguanosine (8‐oxoGuo), and plasma levels of malondialdehyde before and after treatment as a measurement of DNA oxidation, RNA oxidation, and lipid peroxidation, respectively.ResultsClarithromycin significantly increased urinary excretion of 8‐oxodG by 22.0% (95% confidence interval (CI): 3.6–40.4%) and 8‐oxoGuo by 14.9% (95% CI: 3.7–26.1%). Further, we demonstrated that trimethoprim significantly lowered urinary excretion of 8‐oxodG by 21.7% (95% CI: 5.8–37.6%), but did not influence urinary excretion of 8‐oxoGuo. Penicillin V did not influence urinary excretion of 8‐oxodG or 8‐oxoGuo. None of the antibiotic drugs influenced plasma levels of malondialdehyde.ConclusionClarithromycin significantly increases oxidative nucleic acid modifications. Increased oxidative modifications might explain some of clarithromycin's known adverse reactions. Trimethoprim significantly lowers DNA oxidation but not RNA oxidation. Penicillin V had no effect on oxidative nucleic acid modifications.
Hand–Eye Coordination Predicts Joint Attention
Authors: Yu Chen , Smith Linda B. 
Published: February 2017

The present article shows that infant and dyad differences in hand–eye coordination predict dyad differences in joint attention (JA). In the study reported here, 51 toddlers ranging in age from 11 to 24 months and their parents wore head‐mounted eye trackers as they played with objects together. We found that physically active toddlers aligned their looking behavior with their parent and achieved a substantial proportion of time spent jointly attending to the same object. However, JA did not arise through gaze following but rather through the coordination of gaze with manual actions on objects as both infants and parents attended to their partner's object manipulations. Moreover, dyad differences in JA were associated with dyad differences in hand following.
Professional interpersonal dynamics and burnout in European transplant surgeons
Authors: Jesse Michelle T. , Abouljoud Marwan , Eshelman Anne , De Reyck Chantal , Lerut Jan 
Published: February 2017

AbstractBackgroundBurnout within the health professions has become an increasingly important topic. Evidence suggests there are differences in burnout across different countries. Research has yet to examine burnout in transplant surgeons throughout Europe.MethodsA cross‐sectional survey of transplant surgeons across Europe. Survey included sociodemographics, professional characteristics, frequency and discomfort with difficult patient interactions (PI), decisional autonomy, psychological job demands (PJD), support (coworker, supervisor, and hospital administration), and burnout including emotional exhaustion (EE), depersonalization (DP), and personal accomplishment (PA).ResultsOne hundred and eight transplant surgeons provided data; 33 (30.6%) reported high EE, 19 (17.6%) reported high DP, and 29 (26.9%) reported low PA. Three hierarchical multiple linear regressions examined the burnout subscales as outcomes (EE, DP, and PA), and predictors selected based upon theoretical relationships with the outcomes. Greater PJD, greater discomfort in managing difficult PI, and lower levels of perceived supervisor support (SS) predicted greater EE. Only decisional autonomy significantly predicted DP, accounting for a small proportion of the variance. None of the steps for PA were significant.ConclusionsGiven prior research on burnout, there were several surprising findings from this study. For example, the relatively low levels of EE compared to U.S. physicians and surgeons. At this time, we can only hypothesize why this finding occurred but there are multiple possible explanations including cultural effects, response bias, or other factors unknown at this time. Research is needed to attempt to clarify these findings.
Impaired intestinal cholecystokinin secretion, a fascinating but overlooked link between coeliac disease and cholesterol gallstone disease
Authors: Wang Helen H. , Liu Min , Li Xiaodan , Portincasa Piero , Wang David Q.‐H. 
Published: February 2017

AbstractBackgroundCoeliac disease is a chronic, small intestinal, immune‐mediated enteropathy caused by a permanent intolerance to dietary gluten in genetically predisposed individuals. Clinical studies have found that intestinal cholecystokinin secretion and gallbladder emptying in response to a fatty meal are impaired before coeliac patients start the gluten‐free diet (GFD).DesignHowever, it was never really appreciated whether coeliac disease is associated with gallstones because there were very few studies investigating the mechanism underlying the impact of coeliac disease on the pathogenesis of gallstones.ResultsWe summarize recent progress on the relationship between coeliac disease and gallstones and propose that coeliac disease is an important risk factor for gallstone formation because defective intestinal cholecystokinin secretion markedly increases susceptibility to cholesterol gallstones via a mechanism involving dysmotility of both the gallbladder and the small intestine. Because GFD can significantly improve the coeliac enteropathy, early diagnosis and therapy in coeliac patients is crucial for preventing the long‐term impact of cholecystokinin deficiency on the biliary and intestinal consequences. When gluten is reintroduced, clinical and histologic relapse often occurs in coeliac patients. Moreover, some of the coeliac patients do not respond well to GFD.ConclusionsIt is imperative to routinely examine by ultrasonography whether gallbladder motility function is preserved in coeliac patients and monitor whether biliary sludge (a precursor of gallstones) appears in the gallbladder, regardless of whether they are under the GFD programme. To prevent gallstones in coeliac patients, it is urgently needed to investigate the prevalence and pathogenesis of gallstones in these patients.
Pattern of oral‐maxillofacial trauma from violence against women and its associated factors
Authors: da Nóbrega Lorena Marques , Bernardino Ítalo de Macedo , Barbosa Kevan Guilherme Nóbrega , e Silva Jéssica Antoniana Lira , Massoni Andreza Cristina de Lima Targino , d'Avila Sérgio 
Published: February 2017

AbstractBackground/AimViolence against women is a global public health problem. The aim of this study was to characterize the profile of women victims of violence and identify factors associated with maxillofacial injuries.Material and MethodsA cross‐sectional study was performed based on an evaluation of 884 medico‐legal and social records of women victims of physical aggression treated at the Center of Forensic Medicine and Dentistry in Brazil. The variables investigated were related to the sociodemographic characteristics of victims, circumstances of aggressions, and patterns of trauma. Descriptive and multivariate statistics using decision tree analysis by the Chi‐squared automatic interaction detector (CHAID) algorithm, as well as univariate and multivariate Poisson regression analyses were performed.ResultsThe occurrence of maxillofacial trauma was 46.4%. The mean age of victims was 29.38 (SD=12.55 years). Based on decision tree, the profile of violence against women can be explained by the aggressor's gender (P<.001) and sociodemographic characteristics of victims, such as marital status (P=.001), place of residence (P=.019), and educational level (P=.014). Based on the final Poisson regression model, women living in suburban areas were more likely to suffer maxillofacial trauma (PR=1.752;CI95%=1.153‐2.662;P=.009) compared to those living in rural areas. Moreover, aggression using a weapon resulted in a lower occurrence of maxillofacial trauma (PR=0.476;CI95%=0.284‐0.799;P=.005) compared to cases of aggression using physical force.ConclusionsThe prevalence of oral‐maxillofacial trauma was high, and the main associated factors were place of residence and mechanism of aggression.
Adult motor phenotype differentiates Dravet syndrome from Lennox‐Gastaut syndrome and links SCN1A to early onset parkinsonian features
Authors: Aljaafari Danah , Fasano Alfonso , Nascimento Fábio A. , Lang Anthony E. , Andrade Danielle M. 
Published: February 2017

SummaryDistinguishing adult patients with Lennox‐Gastaut syndrome from those with Dravet syndrome is challenging. We have previously reported that patients with Dravet syndrome present a very peculiar motor phenotype. Here we sought to confirm that this association was not linked to the chronic use of antiepileptic drugs or the many lifetime seizures. To this aim, we studied 14 adult patients with Lennox‐Gastaut syndrome and 14 adults with Dravet syndrome because both conditions share similar seizure severity. We found that antecollis and parkinsonian gait were significantly more common in the Dravet group, thus suggesting that these features are part of the Dravet syndrome adult phenotype.
Impact of compressive hold on out‐of‐phase thermomechanical fatigue crack growth in IN 718
Authors: Radzicki A. T. , Johnson W. S. , Neu R. W. , Annigeri B. S. , Ziegler B. M. 
Published: February 2017

AbstractAccurate characterization and understanding of the fatigue crack growth behaviour of components in jet turbine engines is critical for successfully using a damage tolerant design method to maximise safety and efficiency. The hot section components experience changing loads and temperatures, and hence, fatigue crack growth rates are typically studied under thermomechanical loading. One question that remains unclear is the role of the compressive holds that are often part of an aircraft loading‐temperature spectrum. This experimental study was undertaken to investigate a turbine disk alloy, Inconel 718, subjected to different cycling and temperature profiles considering different lengths of hot compressive holds to determine its effect on the fatigue crack growth rate. It was found that the addition of a compressive hold at temperatures from 650 to 725 °C has no significant impact on the fatigue crack growth rate when compared with a cycle without a compressive hold. Fractographic analysis shows that crack growth is primarily transgranular in all cases studied suggesting that grain boundary oxidation, often observed during hot tensile holds, is insignificant.