bluuebunny/crossref_metadata_2025_split huggingface dataset:
CRISPR-Cas-Induced Mutants Identify a Requirement for dSTIM in Larval Dopaminergic Cells of Drosophila melanogaster
Authors: Pathak Trayambak , Trivedi Deepti , Hasan Gaiti 
Published: January 2017

Abstract
Molecular components of store-operated calcium entry have been identified in the recent past and consist of the endoplasmic reticulum (ER) membrane-resident calcium sensor STIM and the plasma membrane-localized calcium channel Orai. The physiological function of STIM and Orai is best defined in vertebrate immune cells. However, genetic studies with RNAi strains in Drosophila suggest a role in neuronal development and function. We generated a CRISPR-Cas-mediated deletion for the gene encoding STIM in Drosophila (dSTIM), which we demonstrate is larval lethal. To study STIM function in neurons, we merged the CRISPR-Cas9 method with the UAS-GAL4 system to generate either tissue- or cell type-specific inducible STIM knockouts (KOs). Our data identify an essential role for STIM in larval dopaminergic cells. The molecular basis for this cell-specific requirement needs further investigation.
Who should care for people with bleeding disorders?
Authors: Harrison Cathy 
Published: January 2017

Abstract
An integrated model of specialised-delivered care is widely accepted as the standard of care for people with haemophilia in the UK. Assessment of available evidence on patient outcomes confirms this approach. But leading the specialist care for this group of patients does not require a medical qualification. Specialist nursing is well established within the haemophilia service and offers perhaps the greatest resource as health services cope with cost constraints on the specialist provision of services.
Neonatal circumcision in patients with haemophilia is safe – a single centre experience
Authors: Barg Assaf Arie , Mendelovich Sarina Levy , Lalezari Shadan , Aviv Shirley Azar , Bashari Dalia , Kenet Gili 
Published: January 2017

Abstract
Consensus evidence-based guidelines regarding prophylactic treatment for circumcision in patients with haemophilia are lacking. In this study, we retrospectively examined the results of circumcision of 40 consecutive neonates with haemophilia, diagnosed after delivery. Our protocol included application of a single dose of factor replacement prior to the procedure and 3 days’ oral treatment with tranexamic acid. Only 3/40 neonates with haemophilia experienced mild postcircumcision bleeding. No major or any life-threatening bleeds were encountered. As the therapy administered was minimal and the procedure simple and feasible, we concluded that circumcision in neonates with haemophilia should be performed according to family’s and physician’s discretion. Avoidance of circumcising male babies with haemophilia due to fear of bleeding complications is not supported by the results shown within our patient cohort.
Impact of intestinal helminths on the risks of gastrointestinal haemorrhage and iron deficiency among haemophilia patients in northern Nigeria
Authors: Ibrahim Umma A. , Ahmed Sagir G. , Kagu Modu B. , Abjah Usman A. 
Published: January 2017

Abstract
We predicted that haemophilia would create a prohaemorrhagic host-parasite relationship, which would make haemophiliacs very vulnerable to haemorrhagic effects of intestinal helminths in tropical countries like Nigeria. If our prediction is correct, the frequency and risks of gastrointestinal haemorrhage and iron deficiency will be higher among haemophiliacs infected by helminths in comparison with uninfected haemophiliacs. Frequency of gastrointestinal haemorrhages and iron deficiency among haemophiliacs with and without intestinal helminth infections were retrospectively obtained and analysed, and their relative risk determined by regression analysis. Haemophiliacs with intestinal helminths had significantly higher frequencies of gastrointestinal haemorrhage (73.3% vs. 18.5%, p<0.05) and iron deficiency (60% vs. 22.2%, p<0.05) in comparison with haemophiliacs without intestinal helminths. Haemophiliacs with intestinal helminths had significantly elevated relative risks (RR) of gastrointestinal haemorrhage (RR=3.4, CI95%: 2.4- 4.3, p=0.007) and iron deficiency (RR=2.5, CI95%: 1.7-3.3, p=0.009). These results showed that helminth infections were associated with increased risks of gastrointestinal haemorrhage and iron deficiency in haemophiliacs. This is thought to be due to a pro-haemorrhagic host-parasite relationship resulting from host haemostatic abnormality, coupled with the concurrent manipulation of the host haemostatic system by anticoagulants produced by some of the parasites. Haemophiliacs in tropical countries should be regularly screened and treated for intestinal helminths.
What is a nurse-led service? A discussion paper
Authors: Khair Kate , Chaplin Steve 
Published: January 2017

Abstract
The terms ‘nurse-led service’ and ‘nurse-led care’ are often used, but are frequently not well defined. As health care delivery evolves across the world and struggles to cope with changes in medical care and with the rising number of people living longer with long term conditions, it is frequently suggested that more care should be delivered and coordinated by nurses who have the most day-to-day contact with affected individuals and their families. This paper addresses the notion of modern ‘nurse-led’ care in the 21st century, with a focus on haemophilia. Haemophilia is one specialty in which totally nurse-led and delivered care could become a reality, there is already evidence from both developing and developed countries of nurses providing excellent and innovative haemophilia care.
Insulin delivery: what is new in the queue?
Authors: Rahman Syed Kasfur , Kawatra Pallavi 
Published: January 2017

Diabetes Mellitus (DM) is a cluster of metabolic disorders with the shared feature of hyperglycemia which may be due to discrete etiopathogenesis. India stands to be the diabetic capital of the world, second only to China. After its discovery by Banting and Best, it has been established that insulin plays a fundamental role in the management of DM. In spite of insulin being in the market for so long, what still remains a challenge is the invasive approach of its administration. Conventional pharmacotherapeutic approaches of insulin delivery that have been available over the years are insulin syringes, pumps and pens. Upcoming innovative modes of insulin delivery include oral insulin, inhaled insulin, colonic insulin delivery, transdermal insulin, intra-peritoneal insulin, intra-nasal insulin, nano-technology etc. Constant research has been going on since many years to discover a route of administration for insulin that is minimally or noninvasive, effective, safe, convenient and cost-effective for patients. If successful, alternative routes of administration could revolutionize the treatment of DM and help improve patients’ quality of life.
A survey of prescription pattern of antibiotic drugs on patients suffering from ENT infection within Dhaka metropolis
Authors: Karim Rubaba , Uddin Md. Sahab , Rahman M. Sohanur , Nure Most. Akhlatun , Saha Rita Rani , Begum Taslima , Begum Rayhana , Islam Azharul , Begum Mst. Marium 
Published: January 2017

Background: This survey was designed to assess and evaluate the prescription pattern of antibiotic drugs on patients suffering from ENT infection within Dhaka metropolis.Methods: A cross sectional, observational and prospective study was conducted from January to June 2015 in the out-patients (OPD) and in-patients (IPD) of ENT department at different general and specialized government and private hospitals (Dhaka Medical College and Hospital, Sir Solimullah Medical College Mitford Hospital, Holy Family Red Crescent Medical College and Hospital, Dhaka Community Medical College and Hospital) within Dhaka city.300 prescriptions were collected and randomly evaluated for this present study.Results: Out of 300 patients, 220 (73.33%) were male and 80 (26.67%) were female (including children and adults) where most of the patients were outpatients 262 (87.33%). In the patients information section it was observed that approximately 93.33% prescription contained antibiotic drugs and almost all prescription (100%) contained antibiotic drugs along with other drugs such as 80.67%PPI (proton pump inhibitors), 76.67% analgesic and 51.33% vitamin / iron supplements. From this analysis we found that 19.33% prescription contained single antibiotic drug, 80.67% contained two antibiotic drugs and no prescription contained more than two antibiotic drugs. Most of the prescribed drugs were administered orally (12% capsule, 80% tablet form). Out of 473 prescribed antibiotic drugs majority of them lie underβ-Lactam (54%) class followed by cephalosporin (46.33%) class in which maximum drugs (92%) were prescribed by their brand names.Conclusions: Prescribing more than one antibiotics was commonly encountered in this study indicating the occurrence of polypharmacy. Interventions to rectify over prescription of antibiotics, use of brand names, inadequate labelling of drugs is necessary to improve rational drug use. Standard treatment guidelines, hospital formulary, and educational intervention become essential to modify this behaviour to benefit the patient.
A case report of life threatening Dapsone Hypersensitivity Syndrome
Authors: Jeevangi Santoshkumar R. , Saba Amreen 
Published: January 2017

Dapsone is widely used for a variety of infections, immune and hypersensitivity disorders. However, the use of Dapsone may be associated with a plethora of adverse effects, the most serious being Dapsone Hypersensitivity Syndrome (DHS) wherein the patient typically presents with a triad of fever, skin eruption and internal organ involvement, that occurs during first 2 to 8 weeks of initiating the treatment. The incidence of DHS ranges from 0.5% to 3%. Here we report a case of severe life threatening Dapsone induced hypersensitivity reaction in a 21year old female who presented with high grade fever, generalized lymphadenopathy, skin rash and hepato-splenomegaly. This condition is best approached with immediate discontinuation of offending drug and prompt administration of oral or IV glucocorticoids. The case is being reported to emphasize the need for timely diagnosis and prompt treatment for successful outcome as it can cause irreversible organ damage or death if untreated early.
Docência compartilhada: estratégia didática para a educação de adolescentes, jovens e adultos do município de Goiânia (GO)
Authors: Moreira Fabíola Correia de Souza Araújo , Shuvartz Marilda 
Published: January 2017

A Educação de Jovens e Adultos (EJA), modalidade de educação amparada pela Lei de Diretrizes e Bases da Educação Nacional (Lei 9394/96 – LDB), há muito, vem sendo negligenciada em sua elaboração, visto que não é privilegiada de políticas públicas educacionais brasileiras. São notórios, nas características desta modalidade, aspectos pedagógicos específicos, para que o sujeito trabalhador alcance um aprendizado significativo durante sua estada na escola. Para isso é importante que os professores estejam preparados para situações pedagógicas nunca antes vivenciadas, com formação específica para esse público. Faz-se necessário, também, que o professor adote posturas e práticas pedagógicas capazes de proporcionar esse aprendizado. O presente artigo relata uma experiência pedagógica possível para os sujeitos da EJA, a docência compartilhada. Nessa proposta, dois professores compartilharam seus planejamentos e conteúdos, proporcionando uma (re)significação de suas práticas pedagógicas, viabilizando a inclusão dos alunos da EJA. As áreas de Ciências da Natureza e Ciências Humanas direcionaram uma pedagogia diferenciada, demonstrando as possibilidades de se alcançar um aprendizado significativo na EJA, em uma escola municipal de Goiânia.Palavras-chave: EJA; Docência compartilhada; Pedagogia diferenciada; Experiência didática. ABSTRACT: The Youth and Adult Education (EJA), type of education supported by the Law of Guidelines and Bases of National Education (Law 9394/96 - LDB) long, has been neglected in its preparation, as it is not privileged public policy Brazilian educational. Are notorious, the characteristics of this type, specific pedagogical aspects, so that the subject worker reach a significant learning during their stay at school. For this it is important that teachers are prepared for teaching situations never before experienced, specially trained for this audience. It is necessary also that the teacher adopt attitudes and teaching practices to provide this learning. This article reports a possible educational experience for the subjects of the EJA, shared teaching. In this proposal, two teachers shared their plans and content, providing (re) signification of their teaching practices, enabling the inclusion of adult education students. Areas of Natural Sciences and Humanities directed a differentiated pedagogy, demonstrating the possibilities of achieving a significant learning in adult education in a municipal school in Goiânia.Keywords: Adult education; Shared teaching; Differentiated learning; Teaching experience.
Agentes/atores envolvidos na institucionalização de políticas públicas de educação ambiental no Brasil e a necessidade do diálogo entre eles
Authors: Nery-Silva Ana Clara 
Published: January 2017

Buscando panoramas gerais sobre pesquisas em educação ambiental, o presente estudo investigou agentes/atores envolvidos nos processos de elaboração e implementação de políticas públicas federais de educação ambiental no Brasil. Foram encontrados diferentes agentes/ atores, divididos em duas categorias: governamentais e não-governamentais. Na primeira, estão presidentes, ministros, deputados federais, ministérios e secretarias de educação. Já na segunda, encontram-se comissões, conselhos e comitês da sociedade civil (incluindo movimentos sociais e organizações não- governamentais), educadores e corporações econômicas. Conclui-se que é necessário um maior diálogo entre os agentes/ atores envolvidos em cada uma das etapas para que as políticas elaboradas façam sentido ao serem implementadas em diferentes espaços educativos. Considera-se, também, que é necessário que a sociedade civil e os educadores sejam mais convidados a construir as políticas públicas educacionais, de maneira mais participativa, dialógica e democrática.Palavras-chave: Educação ambiental; Políticas públicas; Agentes/atores. ABSTRACT: Seeking overviews on research in environmental education, this study investigated agents/ actors involved in elaboration and implementation processes of federal public policies for environmental education in Brazil. Was found different agents/ actors, organized in two categories: governmental and non-governmental. In the first, are presidents, ministers, deputies, ministries and departments of education. In the second, can be found commissions, councils and committees of civil society (including social movements and non-governmental organizations), educators and economic corporations. We conclude its necessary for more dialogue between the agents/ actors involved in each step, to the elaborate public policies that can make sense when they are implemented in different educational spaces. It is considered, also, that is necessary than civil society and educators are more invited to build educational public policies, making this by a participative, dialogical and more democratic way.Keywords: Environmental education; Public policies; Agents/actors.
Controversial socio-scientific issues / Controvérsias sociocientíficas: aspectos metodológicos para a aproximação...
Authors: Levinson Ralph , Kato Danilo Seithi 
Published: January 2017

Entrevista com Ralph Levinson coordenada pelo Prof. Dr. Danilo Seithi Kato (UFTM). Ralph Levinson é professor do Instituto de Educação da Universidade de Londres. Ele dirige o mestrado em Educação para Ciências e orienta trabalhos de doutorado. Seus interesses de pesquisa são questões sociocientíficas controversas, ciência e justiça social, educação para ciências e criatividade e pedagogia em ciência. Ele é o autor de “Towards a theoretical framework for teaching controversial socio?scientific issues” (2006) e de “Science education and democratic participation: an uneasy congruence” (2010). Interview with Ralph Levinson coordinated by professor Danilo Seithi Kato (Federal University of Triângulo Mineiro - UFTM). Ralph Levinson is Reader in Education at the Institute of Education (University of London). He is programme director of the MA in Science Education and supervises doctoral students. His research interests are in socio-scientific issues, science and social justice, science education and creativity, and pedagogy in science. He is the author of “Towards a theoretical framework for teaching controversial socio?scientific issues” (2006) and “Science education and democratic participation: an uneasy congruence” (2010).
Phosphorus Removal Characteristics of Titanium Salts Compared with Aluminum Salt
Authors: Jeon Kyeong‐Jun , Kim Jong‐Ho , Ahn Johng‐Hwa 
Published: January 2017

ABSTRACT: This study evaluates the efficacy of titanium tetrachloride (TiCl4) and titanium sulfate [Ti(SO4)2] on phosphorus (P) removal in synthetic wastewater compared with aluminum sulfate [Al2(SO4)3]. Jar test experiments were performed at various chemical doses and initial pH (pHi) levels to determine the conditions at which P removal was most efficient. The doses with 99% P removal were 0.31 to 0.34 mM for TiCl4, 0.15 mM for Ti(SO4)2, and 0.19 mM for Al2(SO4)3 as Al at 2 mg P/L, 100 mg CaCO3/L, and pHi = 7.0 to 8.0. The optimum pHi was 7 for TiCl4, 5.5 for Ti(SO4)2, and 7 for Al2(SO4)3. The P‐removal efficiencies were Ti(SO4)2 > Al2(SO4)3 > TiCl4 at pHi 5.5, and TiCl4 ≈ Al2(SO4)3 > Ti(SO4)2 at pHi 7 and 8.5. P‐removal ability of TiCl4 decreased as alkalinity increased. Quadratic models successfully approximated the response surface for P removal efficiency with simultaneous changes in pHi and chemical concentrations [TiCl4 and Al2(SO4)3].
A Narrative Approach to Identifying Some Underlying Problems in an Urban Hospital's Emergency Room
Authors: Eisenberg Eric M , Pynes Joan E , Baglia Jay 
Published: January 2017

There is a shortage of nurses in America. This article provides an applied example of the value of ethnographic/qualitative research in an urban hospital's emergency room to identify factors associated with nurse turnover and low morale. A narrative that identifies some of the underlying problems in a hospital's emergency room is provided. The authors challenge public administration research methods courses to broaden their focus and incorporate more qualitiative methods.
The Disappearance of the Homemakers Club: A Dilemma for School Leaders
Authors: Ketelle Diane 
Published: January 2017

How can we return to a broader notion of education? There is a currently a need to focus on the public purpose of schooling. The notion of leading with public purpose derives from the progressive idea that human beings have bot hthe desire and capacity to make the world a better place. Educational leadership should engage individuals in the educational and civic community and assist in the bettering of public life and public schooling.
The Politics of Distance Edcucation
Authors: Peterson Mark 
Published: January 2017

"Distance education" at the college level is well over a century old. It has served the needs of a numerically large, but proportionately small population of learners who have eschewed the campus classroom. These correspondence school enrollees, educational TV watchers, and audiocassette listeners have had only modest impact on the structure, mission, and strategy of the institutions serving them. But that is now changing, and changing very dramatically. The advent of the Internet, interactive television technology, and web-based instructional software, coupled with administrative and political perceptions of educational reformation and fiscal efficiency, may be causing nothing less than a revolution in higher education. By applying a feminist model of assessment called "unthinking technology," that is to say, exploring the potential, but unthought of socio-political aspects of this technological revolution, this paper raises significant questions about the security of the traditional academic enterprise. "The Politics of Distance Education" urges a pro-active embrace of these technologies by the academy in order to enable a legitimate "competency for grievance" so that the protection of the validity of higher education, and legitimacy of the academic profession can be ethically defended and publicly respected, rather than being viewed as mulish resistance to the inevitable.
NASPAA Faculty and Their Involvement Distance Edcucation
Authors: Hoffman Marvin , Stefanovic Dragan , Strickland Ruth Ann , Gurley Dan 
Published: January 2017

This paper assesses the current use of distance learning technologies in graduate-level public administration programs in the United States. A telephone survey was undertaken of NASPAA-affiliated MPA programs and responses were received from 100 program directors. Distance learning means a number of different things in different universities, ranging from the email and web supplements to traditional course materials up to and including videoclasses and faculty-student teleconferencing. We find that the number of programs using distance learning is rapidly expanding, with 25 universities now using distance learning techologies and 14 more planning implementation within three years. Although the number of remote sites currently served by a program through distance learning is typically one or two, some statewide programs exist. Among programs using distance education technology, courses typically comprise only a portion of a student's program, but some programs exist in which a student can complete an entire MPA degree from a remote site. This article discusses pedagogical issues, such as optimal class size as well as instructor-student and student-peer interaction. The rationales cited by directors for implementing distance learning are examined. A bibliography is included that directs the reader to additional information regarding future trends in distance education as well as the on-going debate over pedagogical issues relating to distance education.
Community Building in a Distance Delivered MPA Program at the University of Alaska Southeast
Authors: Anderson Jonathan 
Published: January 2017

This paper presents a brief case study of the distance delivered Master of Public Administration program at the University of Alaska Southeast in Juneau, Alaska. The US Department of Education notes that from 1995 to 1998 distance education programs in the US have increased by 72% (complete study available at http://nces.ed.gov/). Many would say one of the greatest challenges to higher education in today's world is the challenge of distance education, particularly distance education mediated by technology. For years, Universities have undertaken distance education through correspondence courses. Despite the existence of such distance education courses, the fact that they were few in number, that they normally involved only preparatory or elective courses, that they rarely involved whole programs, and that they were normally administered by Departments of Continuing Education made them somehow less controversial.
Teaching Criminal Justice Online: A Case Study in Systems Improvement
Authors: Eastep Mary Ann 
Published: January 2017

This case study, examining the experiences of a criminal justice instructor teaching Women and Crime online, highlights some of the issues, challenges and discoveries that surface as the course continues to evolve and improve. Some specific topics include facilitating discussion online, concern about online cheating, the prevalence of online course delivery, performance issues and the "double-edges sword of anonymity." The theme of continuous improvement is emphasized.