bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asociaciones de marcadores moleculares con la resistencia a enfermedades, caracteres morfológicos y agronómicos en familias diploides de papa (Solanum tuberosum L.)
Authors: Gabriel Julio , Veramendi Silene , Pinto Linett , Pariente Leslie , Angulo Ada 
Published: May 2016

<p>Quince familias de papa (840 genotipos) provenientes de cruzas inter-específicas entre especies de Solanum stenotomum, S. goniocalyx y S. phureja fueron genotipadas, con el objetivo de asociar seis marcadores moleculares (GP94, HC, Nl25, Gro 1-4, RYSC3 y CP60) con genes mayores de resistencia para tizón tardío (Phytophthora infestans), verruga (Synchytrium endobioticum), nematodo - quiste (Globodera pallida y G. rostochiensis) y virus PVY y PVX. Los resultados mostraron que cinco de los marcadores aplicados fueron polimórficos y amplificaron en más del 80% de las familias. El marcador RYSC3 que co-localiza con el gen Ry no amplificó en ninguna de las familias evaluadas. La familia 8 amplificó la banda para tres marcadores (CP60, GP94 y NL25) en la totalidad de sus clones. La prueba de χsup2 se utilizó para determinar el ajuste de las proporciones de segregación de cada familia para cada marcador y genotipar los progenitores. Nueve caracteres agronómicos y morfológicos fueron evaluados en la cosecha. Mediante agrupamiento cluster fueron seleccionados 107 clones con resistencia a PVX, P. infestans, G. rostochiensis y S. endobioticum, alto rendimiento y volumen de tubérculos, elevado número de tubérculos y ojos superficiales. Sobre la base de estos resultados, aspectos prácticos para la aplicación eficiente de la selección asistida por marcadores moleculares son discutidos en este artículo.</p>
Primary Cleft Lip and Palate Repair in Assam, India: Does Preoperative Anthropometric Analysis Help Identify Patients with Increased Surgical Risk in a Clinically Prescreened Population?
Authors: Jerome Mairin A. , Gillenwater Justin , Laub Donald R. , Osler Turner , Allan Anna Y. , Restrepo Carolina , Campbell Alex 
Published: May 2016

Objective To compare anthropometric z-scores with incidence of post-operative complications for patients undergoing primary cleft lip or palate repair. Design This was a retrospective observational analysis of patients from a surgical center in Assam, India, and includes a cohort from a single surgical mission completed before the opening of the center. Setting Patients included in the study underwent surgery during an Operation Smile mission before the opening of Operation Smile's Guwahati Comprehensive Cleft Care Center in Guwahati, India. The remaining cohort received treatment at the center. All patients received preoperative assessment and screening; surgery; and postoperative care, education, and follow-up. Patients, Participants Our sample size included 1941 patients and consisted of all patients with complete information in the database who returned for follow-up after receiving primary cleft lip repair or primary cleft palate repair between January 2011 and April 2013. Interventions Preoperative anthropometric measurements. Main Outcome Measure(s) Postoperative complications. Results Anthropometric z-scores were not a significant predictor of adverse surgical outcomes in the group analyzed. Palate surgery had increased risk of complication versus lip repair, with an overall odds ratio of 5.66 ( P < .001) for all patients aged 3 to 228 months. Conclusions Anthropometric z-scores were not correlated with increased risk of surgical complications, possibly because patients were well screened for malnutrition before surgery at this center. Primary palate repair is associated with an approximate fivefold increased risk of developing postoperative complication(s) compared with primary lip repair.
O Marketing Eletrônico como Ferramenta de Comunicação: um Estudo de Caso na Empresa Companhia da Esfiha em Dourados, MS
Authors: Xavier José Ângelo Pinto 
Published: May 2016

<p>Este trabalho desenvolveu-se após estudo de caso, via observação e diagnóstico, da empresa Cia. da Esfiha Ltda., em Dourados, MS, que<br />trabalha no ramo de comida rápida e entrega em domicílio. A empresa não possui departamento, nem agência específica de marketing, as ações são propostas pelo próprio empresário e autor. Durante este estudo de caso foi aplicado um questionário com dez perguntas fechadas, encaminhado por e-mail a uma amostra de duzentos clientes escolhidos aleatoriamente, com esse, buscou-se traçar o perfil e os anseios dos clientes e qual o canal de marketing seria mais eficiente para melhorar a comunicação com eles, uma vez que a empresa não utilizava-se ainda de meios virtuais para comunicação com os clientes. Após este estudo foi observado que os clientes da empresa são em sua maioria jovens e moram em lares com quatro a cinco indivíduos, tem uma frequência de pedidos de comida por telefone próximo de duas vezes por semana, tem a usabilidade de internet diária, e preferem comunicar-se por este meio pela maior comodidade, e utilizam como meio de comunicação rápido<br />e eficaz o formulário virtual.</p>
Takotsubo Syndrome: A Complex and Varied Clinical Syndrome
Authors: Shewan Louise , Henein Michael , Coats Andrew 
Published: May 2016

<p class="normal">This special issue includes expert reviews and original research on Takotsubo syndrome (TTS) including the history of its identification and the unravelling of the pathophysiology of the different variants of the syndrome. The role of neurological stress or catecholaminergic overload are reviewed, as is the role of CNS disorders triggering TTS. Clinical presentation patterns of TTS and the most useful diagnostic tests are reviewed, including original research into a novel clinical score the ‘GET QT' score to help in rapid differentiation of TTS from STEMI. There is also a review of TTS in the intensive care unit setting. The mechanisms of TTS including the role and assessment of the microcirculation in generating the classical myocardial dysfunction are reviewed in detail, as are the pathophysiological pathways of recurrent TTS. Lastly Singh, Akashi and Horowitz review the emerging treatment options for TTS. They issue also includes multiple elegant and fascinating case reports. TTS has come of age and now urgently adequate sized RCT’s. </p>
Museus de Arte Contemporânea: entre bancos de dados e narrativas
Authors: Freire Cristina 
Published: May 2016

Resumo O caráter documental das práticas artísticas define um dos principais paradigmas da arte contemporânea. A relação entre obra de arte e documentação indica os paralelos entre museu e arquivo, narrativas e banco de dados. Abstract The documental character of the artistic practices defines one of the main paradigms of contemporary art. The relationship between work of art and documentation suggests the parallels between museum and archives, as well as narratives and data banks.
Dificuldades, Reflexões e Possibilidades no Ensino da história da Música no Brasil do Nosso Tempo
Authors: Castagna Paulo 
Published: May 2016

Resumo Este artigo visa contribuir para a discussão sobre as necessárias mudanças no conceito, título e conteúdo das disciplinas “História da Música” e similares, destinadas ao aumento de sua eficiência no ensino musical da atualidade. Para esse objetivo, aborda-se o possível declínio da função do título e do conceito dessa disciplina na atualidade, propondo-se o título mais aberto de “Música, História, Cultura e Sociedade”. O artigo também discute a relação entre autor e professor, e entre disciplinas obrigatórias e optativas, destacando a urgência, na área de Música, de uma reforma curricular (especialmente da disciplina em questão) voltada às necessidades atuais. Abstract This article aims to contribute to the discussion about the necessary changes in the concept, title and content of the course “History of Music” and other similar courses, in order to increase its efficiency in the music education of our time. For this purpose, the text approaches the possible decline of the function of the title and the concept of this course in the present time, pro- posing the more opened title “Music, History, Culture and Society”. The article also discusses the relationship between author and teacher, and between compulsory courses and optional courses, highlighting the urgency of the curriculum reform in the Music area (especially in History of Music) intended to the current needs.
Os caminhos da pesquisa em poéticas visuais através de uma prática pessoal em pintura
Authors: Peruffo Ricardo 
Published: May 2016

Este artigo propõe-se como uma reflexão a respeito, e a partir, das investigações que empreendi nos últimos dez anos, durante o período do Mestrado e do Doutorado em Artes Visuais, no estabelecimento de um processo pictórico que elaborei como artista/pesquisador na linha de Poéticas Visuais. O propósito deste texto é argumentar, valendo-se de uma experiência pessoal de investigação, o que caracteriza e constitui uma pesquisa em Poéticas Visuais. A premissa nesse percurso foi a de que uma pesquisa nesta linha deve contemplar os meandros de sua própria construção, concomitantemente a esse fazer. Ou seja, estudos e análises são guiados pelos desdobramentos do trabalho de ateliê e, simultaneamente, fornecem os parâmetros para a continuidade desse processo.
Elevated MicroRNA‐128 in Periodontitis Mitigates Tumor Necrosis Factor‐α Response via p38 Signaling Pathway in Macrophages
Authors: Na Hee Sam , Park Mi Hee , Song Yu Ri , Kim Seyeon , Kim Hyung‐Joon , Lee Ju Youn , Choi Jeom‐Il , Chung Jin 
Published: May 2016

Background: Periodontitis is a chronic inflammatory disease resulting from an inflammatory response to subgingival plaque bacteria, including Porphyromonas gingivalis. MicroRNA (miRNA) is a current focus in regulating the inflammatory processes. In this study, the inflammatory miRNA expression in gingival tissues of patients with periodontitis and of healthy individuals is compared, and its role in regulating the inflammatory response is examined.Methods: Gingival tissues from patients with periodontitis and healthy individuals were collected for miRNA microarray. THP‐1 and CA9‐22 cells were challenged with P. gingivalis, and miRNA expression was determined by real‐time polymerase chain reaction. Target genes for miRNA were predicted using TargetScanHuman database, and miRNA gene expressions were reviewed using public databases. For the functional study, THP‐1 cells were transfected with a miRNA‐128 mimic, and target gene expression was compared with THP‐1 cells challenged with P. gingivalis. For the tolerance test, THP‐1 cells transfected with miRNA‐128 mimic were treated with phorbol 12‐myristate 13‐acetate (PMA) or paraformaldehyde (PFA)‐fixed Escherichia coli. Tumor necrosis factor (TNF)‐α production was determined by enzyme‐linked immunosorbent assay, and mitogen‐activated protein kinase (MAPK) protein phosphorylation was determined by Western blot.Results: Gingival tissues from patients with periodontitis showed increased expression of miRNA‐128, miRNA‐34a, and miRNA‐381 and decreased expression of miRNA‐15b, miRNA‐211, miRNA‐372, and miRNA‐656. THP‐1 cells and CA9‐22 cells challenged with P. gingivalis showed increased miRNA‐128 expression. Among the predicted miRNA‐128 target genes, several genes that are involved in MAPK signaling pathway showed similar gene expression pattern between P. gingivalis challenge and miRNA‐128 mimic transfection. In THP‐1 cells transfected with miRNA‐128 mimic, TNF‐α production was lower, and phosphorylation of p38 was inhibited when challenged with PMA or PFA‐fixed E. coli.Conclusion: miRNA‐128 may be involved in mitigating the inflammatory response induced by P. gingivalis in periodontitis.
Determinação do tamanho amostral para a validação de processo de produtos estéreis na indústria farmacêutica
Authors: Wruck Emerson , Julião Fabio S. 
Published: May 2016

Este trabalho teve como objetivo propor uma metodologia para a determinação do tamanho amostral, que consiga inferir resultados para todo o lote inspecionado por amostragem, no processo de inspeção para a validação de processo de produtos estéreis na industria farmacêutica, considerando o problema como um teste de hipóteses, sendo priorizada a especifi cação do erro tipo II. Foi feita a avaliação dos possíveis erros estatísticos envolvidos nos procedimentos farmacopéicos atuais de inspeção e foi sugerida uma adaptação desses procedimentos segundo a metodologia exposta no trabalho.
Grounding research projects in the undergraduate curriculum: assessment strategies
Authors: Laycock Angela 
Published: May 2016

In their 2009 paper, Developing Undergraduate Research and Enquiry, Mick Healey and Alan Jenkins observed, “The key to developing undergraduate research and inquiry is to mainstream it and integrate it into the curriculum for all students” (Healey & Jenkins 2009, 6). The following case study gives an account of the steps taken to incorporate two research projects, one international and one community-based, into the final year undergraduate curriculum resulting in significant student success and programme development. Both used a grounded theory model. This led to the development of an assessment regime to achieve the dual aims of providing the student with the opportunity to learn through participatory research and, at the same time, furnishing the commissioner of the research with meaningful findings and recommendations.
A complete Greenwich degree in a personal learning space
Authors: Rebbeck Geoff 
Published: May 2016

This Case study shows and explains the issues and value of placing a whole Greenwich first degree completed in Jan. 2007 into an e-portfolio. The purpose is to show proof of concept that it is possible and how it looks in basic form, when done retrospectively (6 years later).The completed portfolio was the presentation made at the APT Conference July 2013, audience members also able to access and explore it on personal devices in the session.The Case Study considers whether a degree can be presented inside a portfolio, what the issues are in creating a degree portfolio like this, what limitations may be encountered in the process.It then evaluates the value of this approach, and what might be done with a Greenwich University degree in this form.
Angels in the architecture - and devils in the detail: how the learning space impacts on teaching and learning
Authors: Challinor Jane 
Published: May 2016

An innovative classroom design pioneered in the US, which aims to facilitate greater student engagement, has been piloted in a UK University for the first time. This case study reflects on some of the advantages and the challenges of this technology rich learning space and considers its impact on curriculum design in a module which aims to develop academic, research and digital skills in first year students on an undergraduate Health and Social Care course.
Typo-Resource: developing T&L support materials through collaboration
Authors: Loveland Peter , Moys Jeanne-Louise , Tollett Hannah , Towriss Melissa 
Published: May 2016

This paper reports on a collaborative project between staff and students in the Department of Typography & Graphic Communication at the University of Reading. The Partnerships in Learning and Teaching (PLanT) project here described is a direct response to student needs for better online support materials. Methodologically, the project embeds user-centred design principles within an iterative process of design development and participant research. This process has underpinned the development of a prototype for an online interface called Typo-Resource. The resulting initial prototype addresses the usability and user experience dimensions of an online learning resource, moving beyond providing tutor-identified sets of resources to a multifaceted, collaborative, and visual platform for peer learning.
Nitrous Oxide Fluxes, Soil Oxygen, and Denitrification Potential of Urine‐ and Non‐Urine‐Treated Soil under Different Irrigation Frequencies
Authors: Owens Jen , Clough Tim J. , Laubach Johannes , Hunt John E. , Venterea Rodney T. , Phillips Rebecca L. 
Published: May 2016

Despite increased use of irrigation to improve forage quality and quantity for grazing cattle (Bos taurus, Linnaeus), there is a lack of data that assess how irrigation practices influence nitrous oxide (N2O) emissions from urine‐affected soils. Irrigation effects on soil oxygen (O2) availability, a primary controller of N2O fluxes, is poorly understood. It was hypothesized that increased irrigation frequency would result in lower N2O emissions by increasing soil moisture and decreasing soil O2 concentrations. This would favor more N2O reduction to dinitrogen (N2). We examined effects of high (3‐d) versus low (6‐d) irrigation frequency with and without bovine urine addition to pasture. Nitrous oxide fluxes were measured daily for 35 d. Soil O2, temperature, and water content were continuously measured at multiple depths. Inorganic nitrogen, organic carbon, and soil pH were measured at 6‐d intervals. Measurements of denitrification enzyme activity with and without acetylene inhibition were used to infer the N2O/(N2O + N2) ratio. The N2O/(N2O + N2) ratio was lower under high‐ compared with low‐frequency irrigation, suggesting greater potential for N2O reduction to N2 with more frequent irrigation. Although N2O fluxes were increased by urine addition, they were not affected by irrigation frequency. Soil O2 decreased temporarily after urine deposition, but O2 dynamics did not explain N2O dynamics. Relative soil gas diffusivity (DP/DO) was a better predictor of N2O fluxes than O2 concentration. On a free‐draining soil, increasing irrigation frequency while providing the same total water volume did not enhance N2O emissions under ruminant urine patches in a grazed pasture.Core Ideas
Irrigation effects on N2O emissions from ruminant urine patches are rarely studied.
Irrigation frequency influenced soil oxygen and N2O reductase enzyme.
N2O emission was unaffected by irrigation frequency on a free‐draining soil
Soil gas diffusivity (DP/DO) was a strong predictor of cumulative N2O emissions.
Ocular Tolerability of Preservative-Free Tafluprost and Latanoprost: in vitro and in vivo Comparative Study
Authors: Esaki Yoshihiko , Shimazaki Atsushi , Pellinen Pertti 
Published: May 2016

Objective:
Detrimental effects of the preserved prostaglandin analogs (PGAs) have been thoroughly documented in the published literature. The current work studied two preservative-free (PF) prostaglandin eye drops: PF tafluprost and PF latanoprost. The aim of the study was to compare these two PF formulations in vitro for viability of the human corneal epithelial (HCE-T) cells and in vivo for ocular tolerability of the rabbit eye.

Method:
Viability of the HCE-T cells was measured by the MTS assay. The SV40-immortalized HCE-T cells were exposed to 100 µL of the drug solutions (at their commercial concentrations) or the culture medium. Ocular irritation was evaluated after repeated instillation of the drug solutions in Japanese white rabbits (Kbl:JW).

Results:
A significant loss of HCE-T cell viability was observed in vitro immediately after the exposure to PF latanoprost formulation but not immediately after the exposure to PF tafluprost formulation. Congruently, PF latanoprost induced in vivo more irritation on the rabbit eye than PF tafluprost.

Conclusion:
Comparing these two PF formulations in vitro and in vivo, it is considered that ocular tolerability of PF tafluprost is better than PF latanoprost. Taking into account the composition of these two PF PGA formulations, the solubilizing agent macrogolglycerol hydroxystearate 40 (MGHS40) contained in PF latanoprost formulation is a plausible cause for the negative effects.
Mobile Phone and Web-based Cognitive Behavior Therapy for Depressive Symptoms and Mental Health Comorbidities in People Living With Diabetes: Results of a Feasibility Study
Authors: Clarke Janine , Proudfoot Judith , Ma Howard 
Published: May 2016

BackgroundDepression is often comorbid with diabetes; however, undertreatment of depressive symptoms in people affected is common.ObjectiveWe studied preliminary acceptability and effectiveness of a fully automated, mobile phone, and web-based public health intervention, myCompass, for reducing depressive symptoms and improving mental health comorbidities in people with diabetes.MethodsIn this single-group feasibility study, 89 volunteers with type 1 (n=34) or type 2 (n=55) diabetes and at least mild depressive symptoms used myCompass for 7 weeks. Web-based measures of depressive and anxious symptoms, functional impairment, diabetes-specific variables, and user satisfaction were completed at baseline, postintervention, and 3-month follow-up.ResultsRetention rates were 54% (n=48) at postintervention and 36% (n=32) at follow-up. Depressive symptoms were significantly improved at postintervention (P<.001; within-group effect size d=1.05), with gains persisting at follow-up. Mental health comorbidities, including anxiety (P<.001), functioning (P<.001), and diabetes-specific distress (P<.001), also showed significant and sustained improvement. Satisfaction with myCompass was high, with convenience and ease of program use, and relevance of program content rated positively by participants.ConclusionsThe myCompass program shows promise as an acceptable and effective treatment for depression and comorbid mental health problems in people with diabetes. The program is broadly available, free to use, and may benefit patients with diabetes who do not access services and/or wish to manage their mental health themselves. Replication of these findings in a controlled study is warranted.
Properties, weldability and corrosion behavior of supermartensitic stainless steels for on- and offshore applications
Authors: Taban Emel , Kaluc Erdinc , Ojo Olatunji Oladimeji 
Published: May 2016

Abstract
Stimulated material-environment interactions inside and around flowlines of deep or ultra deep wells during oil and gas exploration, and fabrication economy of pipelines have been the major challenges facing the oil and gas industries. Presumably, an extensive focus on high integrity, performance and material economy of flowlines have realistically made supermartensitic stainless steels (SMSS) efficient and effective material choices for fabricating onshore and offshore pipelines. Supermartensitic stainless steels exhibit high strength, good low temperature toughness, sufficient corrosion resistance in sweet and mildly sour environments, and good quality weldability with both conventional welding processes and modern welding methods such as laser beam welding, electron beam welding and hybrid welding approaches. In terms of economy, supermartensitic stainless steels are cheaper and they are major replacements for more expensive duplex stainless steels required for tubing applications in the oil and gas industry. However, weld areas of SMSS pipes are exposed to sulphide stress cracking (SSC), so intergranular stress corrosion cracking (IGSCC) or stress corrosion cracking can occur. In order to circumvent this risk of cracking, a post-weld heat treatment (PWHT) for 5 minutes at about 650 °C is recommended. This paper provides detailed literature perusal on supermartensitic stainless steels, their weldability and corrosion behaviors. It also highlights a major research area that has not been thoroughly expounded in literature; fatigue loading behaviors of welded SMSS under different corrosive environments have not been thoroughly detailed in literature.