bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple data access via a common cavity bus in circuit QED
Authors: Chatterjee Dibyendu , Roy Arijit 
Published: March 2017

SummaryAccessing multiple data through a common bus in quantum information processing is challenging. Experimental demonstration of quantum state transfer between a pair of superconducting phase qubit [M. A. Sillanpää et al., Nature 449, 438 (2007)] motivates us to construct a scheme for accessing and transferring multi‐qubit quantum information through a common cavity bus. Here, we have presented an efficient scheme to access multiple data through single channel using superconducting qubit and superconducting cavity resonator. The qubit–cavity photon coupling offers transfer of quantum data in different location of a quantum processing system from multiple users through a common superconducting cavity resonator. Instead of phase qubit, charge qubit is found to be more advantageous in qubit–cavity interaction for quantum data transformation, because charge qubit is immune to flux and external flux is used to select specific qubit from a set of qubits. The scheme is very generic and provides M‐output from N‐number of inputs via a common cavity in circuit quantum electrodynamics. The flexibility of the scheme allows us to implement multiplexer, demultiplexer, and so on for quantum data manipulation in a similar manner as in classical digital electronics. This scheme is useful to reduce the circuit complexity in quantum processor named as ‘quprocessor’. Copyright © 2017 John Wiley & Sons, Ltd.
Prognostic importance of left ventricular mechanical dyssynchrony in heart failure with preserved ejection fraction
Authors: Biering‐Sørensen Tor , Shah Sanjiv J. , Anand Inder , Sweitzer Nancy , Claggett Brian , Liu Li , Pitt Bertram , Pfeffer Marc A. , Solomon Scott D. , Shah Amil M. 
Published: March 2017

AimsLeft ventricular mechanical dyssynchrony has been described in heart failure with preserved ejection fraction (HFpEF), but its prognostic significance is not known.Methods and resultsOf 3445 patients with HFpEF enrolled in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial, dyssynchrony analysis was performed on 424 patients (12%) by multiple speckle tracking echocardiography strain‐based criteria. The primary dyssynchrony analysis was the standard deviation of the time to peak longitudinal strain (SD T2P LS). Cox proportional hazards models assessed the association of dyssynchrony with the composite outcome of cardiovascular death or heart failure hospitalization. Mean age was 70 ± 10 years, LVEF was 60 ± 8%, and QRS duration was 101 ± 27 ms. Worse dyssynchrony, reflected in SD T2P LS, was associated with wider QRS, prior myocardial infarction, larger LV volume and mass, and worse systolic (lower LVEF and global longitudinal strain) and diastolic (lower e' and higher E/e') function. During a median follow‐up of 2.6 (interquartile range 1.5–3.8) years, 107 patients experienced the composite outcome. Worse dyssynchrony was associated with the composite outcome in unadjusted analysis [hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.01–1.07; P = 0.021, per 10 ms increase], but not after adjusting for clinical characteristics, or after further adjustment for LVEF, AF, NYHA class, stroke, heart rate, creatinine, haematocrit, and QRS duration (HR 1.03, 95% CI 0.99–1.06; P = 0.16, per 10 ms increase).ConclusionWorse LV mechanical dyssynchrony, assessed by speckle tracking echocardiography, is not an independent predictor of adverse outcomes in HFpEF, suggesting that mechanical dyssynchrony is unlikely to be an important mechanism underlying this syndrome. These findings warrant validation in an independent study specifically designed to assess the prognostic utility of mechanical dyssynchrony in HFpEF.Trial registration: NCT00094302
Photolabile Ruthenium(II)–Purine Complexes: Phototoxicity, DNA Binding, and Light‐Triggered Drug Release
Authors: Chan Hazel , Ghrayche Joy B. , Wei Jianhua , Renfrew Anna K. 
Published: March 2017

AbstractInvited for the cover of this issue is the group of Anna Renfrew from The University of Sydney, Australia. The cover image shows a light beam directed at a tumor. As a result of light irradiation, a photolabile ruthenium complex releases the anticancer agent 6‐mercaptopurine.
Influences of trehalose‐modification of solid lipid nanoparticles on drug loading
Authors: Wen Zhen , Lin Jing , Su Junqing , Zheng ZongKun , Chen Qing , Chen Lidi 
Published: March 2017

The aim of the present work is to evaluate influences of doping trehalose into solid lipid nanoparticles (SLNs) on drug loading. SLNs were prepared by the emulsion‐evaporation and low temperature‐solidification method, using glyceryl monostearate as a lipid, phosphatidylcholine as a surfactant, trehalose as a modifier and resveratrol as a model drug. As the SLNs were doped by trehalose at a low amount [m(trehalose):m(lipids) = 1:5], entrapment efficiency and loading capacity were enhanced to (81.37 ± 1.50) and (8.71 ± 0.13)%, respectively. Based on morphology, phase transformation and crystalline structure of SLNs, trehalose was doped into lipid matrix in a non‐crystalline state, disrupting the lipid crystallinity and inducing lattice defects.The lipid matrix was crystallized in polymorphic forms composed of α‐form and β′‐form and β‐form, resulting in prevention of drug expulsion from the lipid matrix. The trehalose was interacted with the lipid, facilitating the formation of trehalose/lipid eutectic dopant. The dopant contained lattice defects, allowing for the incorporation of more resveratrol in a amorphous state, contributing to increase of entrapment efficiency and loading capacity. These results confirm stabilizing effects of doping trehalose on improvement of drug loading are attributed to the lipid crystal type and structure of lipid matrix containing lattice defects.Practical applications: Trehalose‐doping is an innovative approach to the improvement of loading properties of SLNs. Compared with ordinary SLNs, SLNs doped with trehalose at low amounts exhibit higher drug loading, presenting the potential utility of these nanoparticles as a drug delivery system for hydrophobic drugs.Trehalose modification on improvement of drug loading of SLNs are attributed to the lipid crystal type and structure of lipid matrix containing lattice defects induced by doping trehalose.
Cholesterol can modulate mitochondrial aquaporin‐8 expression in human hepatic cells
Authors: Danielli Mauro , Capiglioni Alejo M. , Marrone Julieta , Calamita Giuseppe , Marinelli Raúl A. 
Published: March 2017

AbstractHepatocyte mitochondrial aquaporin‐8 (mtAQP8) works as a multifunctional membrane channel protein that facilitates the uptake of ammonia for its detoxification to urea as well as the mitochondrial release of hydrogen peroxide. Since early oligonucleotide microarray studies in liver of cholesterol‐fed mice showed an AQP8 downregulation, we tested whether alterations of cholesterol content per se modulate mtAQP8 expression in human hepatocyte‐derived Huh‐7 cells. Cholesterol loading with methyl‐β‐cyclodextrin (mβCD):cholesterol complexes downregulated the proteolytic activation of cholesterol‐responsive sterol regulatory element‐binding protein (SREBP) transcriptions factors 1 and 2, and the expression of the target gene 3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR). Under such conditions, mtAQP8 mRNA and protein expressions were significantly reduced. In contrast, cholesterol depletion using mβCD alone increased SREBP‐1 and 2 activation and upregulated HMGCR and mtAQP8 mRNA and protein expressions. The results suggest that cholesterol can regulate transcriptionally human hepatocyte mtAQP8 expression likely via SREBPs. The functional implications of our findings are discussed. © 2017 IUBMB Life, 69(5):341–346, 2017
Moderate selenium dosing inhibited chromium (VI) toxicity in chicken liver
Authors: Wang Yang , Liu Yongxia , Wan Huiyu , Zhu Yiran , Chen Peng , Hao Pan , Cheng Ziqiang , Liu Jianzhu 
Published: March 2017

AbstractThis study aimed to clarify the effect of selenium (Se) on chromium (VI) [Cr(VI)]‐induced damage in chicken liver. A total of 105 chickens were randomly divided into seven groups of 15. Group I received deionized water; group II received Cr(VI) (7.83 mg/kg/d) alone; and other groups orally received both Cr(VI) (7.83 mg/kg/d) and Se of different doses (0.14, 0.29, 0.57, 1.14, and 2.28 mg/kg/d). The levels of superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), Ca2+‐ATPase, and mitochondrial membrane potential (MMP) were measured. Results showed that Cr(VI) increased MDA content and decreased GSH content, T‐SOD activity, Ca2+‐ATPase activity, and MMP level. Meanwhile, Se co‐treatment (0.14, 0.29, and 0.57 mg/kg/d) increased the viability of the above indicators compared with Cr(VI)‐treatment alone. In addition, histopathologic examination revealed that Cr(VI) can cause liver damage, whereas Se supplementation of moderate dose inhibited this damage. This study confirmed that Se exerted protective effect against Cr(VI)‐induced liver damage.
A Novel Water‐Soluble Fluorescence Probe with Wash‐Free Cellular Imaging Capacity Based on AIE Characteristics
Authors: Qian Yunxia , Liu Hongmei , Tan Haijian , Yang Qingmin , Zhang Shuchen , Han Lingui , Yi Xuegang , Huo Li , Zhao Hongchi , Wu Yonggang , Bai Libin , Ba Xinwu 
Published: March 2017

A potential real‐time imaging water‐soluble fluorescent polymer (P3) is facilely prepared via one‐pot method. For P3, tetraphenylethene unit serves as the fluorescent unit, poly(acryloyl ethylene diamine) (a kind of polyelectrolyte) with specific degree of polymerization acts as water‐soluble part. 1H‐NMR, gel permeation chromatography (GPC), UV‐vis spectroscopy, photoluminescence (PL), and confocal laser scanning microscopy are undertaken to characterize the structure and property of P3. The results of wash‐free cellular imaging show that the signal‐to‐noise ratio is high as the concentration of P3 is 50 μg mL−1. In addition, the pH‐responsive and Cd2+‐responsive are also investigated in this paper. The results coming from pH‐responsive show that P3 solution displays significant fluorescence under near neutral. And the result from the cellular imaging shows that intracellular fluorescence intensity enhances with the augment of concentration of Cd2+, which reveals that P3 can give a hint to resolve the dilemma of traditional fluorescent dyes used as living cellular fluorescent probe.
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Synthesis of Poly(vitamin C) through ADMET
Authors: Luleburgaz Serter , Abuaf Meir , Tunca Umit , Hizal Gurkan , Durmaz Hakan 
Published: March 2017

l‐Ascorbic acid, commonly known as vitamin C and one of the most important biological compounds, is converted to a α,ω‐diene monomer and subsequently polymerized for the first time by acyclic diene metathesis. Various experimental conditions such as polymerization medium, catalyst type, temperature, and monomer/catalyst ratio are studied. The moderate molecular weight polymers are achieved when the polymerizations are conducted under bulk conditions employing the Grubbs first generation (G1) or Hoveyda–Grubbs second generation catalyst (HG‐2). In the solution case, on the other hand, low molecular weight polymers are obtained regardless of the catalyst type. Moreover, when the catalyst performances are compared, it is found that G1 produces the higher molecular weight as well as higher yield polymers with respect to the HG‐2.
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A UV‐Cleavable Bottlebrush Polymer with o‐Nitrobenzyl‐Linked Side Chains
Authors: Zhu Wen , Zhang Liangcai , Chen Yongming , Zhang Ke 
Published: March 2017

An ultraviolet (UV)‐cleavable bottlebrush polymer is synthesized using the “grafting‐onto” strategy by combining living radical polymerization and copper‐catalyzed azide‐alkyne cycloaddition (CuAAC). In this approach, reversible addition‐fragmentation chain transfer polymerization is used to prepare a poly(methylacrylate) backbone with azide side groups, while atom transfer radical polymerization is employed to prepare polystyrene (PS) side chains end‐functionalized with o‐nitrobenzyl (UV‐cleavable) propargyl groups. CuAAC is then used to graft PS side chains onto the polymer backbone, producing the corresponding bottlebrush polymers with UV‐cleavable PS side chains. The formation of the bottlebrush polymer is characterized by 1H nuclear magnetic resonance spectroscopy, gel permeation chromatography (GPC), and Fourier transform infrared spectroscopy. The cleavage behavior of the bottlebrush polymer is monitored in tetrahydrofuran solution under UV irradiation by GPC and viscosity measurements.
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Plant Oil‐Derived Epoxy Polymers toward Sustainable Biobased Thermosets
Authors: Wang Zhongkai , Yuan Liang , Ganewatta Mitra S. , Lamm Meghan E. , Rahman Md Anisur , Wang Jifu , Liu Shengquan , Tang Chuanbing 
Published: March 2017

Epoxy polymers (EPs) derived from soybean oil with varied chemical structures are synthesized. These polymers are then cured with anhydrides to yield soybean‐oil‐derived epoxy thermosets. The curing kinetic, thermal, and mechanical properties are well characterized. Due to the high epoxide functionality per epoxy polymer chain, these thermosets exhibit tensile strength over an order of magnitude higher than a control formulation with epoxidized soybean oil. More importantly, thermosetting materials ranging from soft elastomers to tough thermosets can be obtained simply by using different EPs and/or by controlling feed ratios of EPs to anhydrides.
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Synthesis and Characterization of a Soluble A–D–A Molecule Containing a 2D Conjugated Selenophene‐Based Side Group for Organic Solar Cells
Authors: Shin Yurim , Song Chang Eun , Lee Woo‐Hyung , Lee Sang Kyu , Shin Won Suk , Kang In‐Nam 
Published: March 2017

A new acceptor–donor–acceptor (A–D–A) small molecule based on benzodithiophene (BDT) and diketopyrrolopyrrole (DPP) is synthesized via a Stille cross‐coupling reaction. A highly conjugated selenophene‐based side group is incorporated into each BDT unit to generate a 2D soluble small molecule (SeBDT‐DPP). SeBDT‐DPP thin films produce two distinct absorption peaks. The shorter wavelength absorption (400 nm) is attributed to the BDT units containing conjugated selenophene‐based side groups, and the longer wavelength band is due to the intramolecular charge transfer between the BDT donor and the DPP acceptor. SeBDT‐DPP thin films can harvest a broad solar spectrum covering the range 350–750 nm and have a low bandgap energy of 1.63 eV. Solution‐processed field‐effect transistors fabricated with this small molecule exhibit p‐type organic thin film transistor characteristics, and the field‐effect mobility of a SeBDT‐DPP device is measured to be 2.3 × 10−3 cm2 V−1 s−1. A small molecule solar cell device is prepared by using SeBDT‐DPP as the active layer is found to exhibit a power conversion efficiency of 5.04% under AM 1.5 G (100 mW cm−2) conditions.
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A pneumatic phantom for mimicking respiration‐induced artifacts in spinal MRI
Authors: De Tillieux Philippe , Topfer Ryan , Foias Alexandru , Leroux Iris , El Maâchi Imanne , Leblond Hugues , Stikov Nikola , Cohen‐Adad Julien 
Published: March 2017

PurposeTo design a phantom capable of mimicking human respiration to serve as a testing platform for correction of the static and time‐evolving magnetic field distortions typically encountered in MRI of the spinal cord.MethodsAn inflation system to mimic the air variation of the human lungs was constructed. The inflation system was linked to a phantom containing synthetic lungs and an ex vivo human spine. The relationship between air pressure and phantom lung volume was evaluated via imaging experiment. The geometric distortion (pseudo‐displacement) caused by the
inhomogeneities was measured on echo planar imaging slices for different air volumes.ResultsLinear and quadratic relations linking air pressure to phantom lung volume were observed with a Pearson correlation coefficient of 0.99. Air distribution was uneven across the synthetic lungs, exhibiting a left‐to‐right lung volume ratio of up to 5/4. The pseudo‐displacement artifact of the spine caused by the air‐filled lungs was observed.ConclusionThe proposed phantom can reproduce the lung volume variation of human respiration and thus can serve as a reliable testing platform for the correction of the associated time‐varying B0 field distortions. Details of the construction and code for the inflation system microcontroller are available for download as open source. Magn Reson Med 79:600–605, 2017. © 2017 International Society for Magnetic Resonance in Medicine.
Susceptibility of insecticide‐resistant bed bugs (Cimex lectularius) to infection by fungal biopesticide
Authors: Barbarin Alexis M , Bellicanta Giovani S , Osborne Jason A , Schal Coby , Jenkins Nina E 
Published: March 2017

AbstractBACKGROUNDBed bugs are a public health concern, and their incidence is increasing worldwide. Bed bug infestations are notoriously difficult to eradicate, further exacerbated by widespread resistance to pyrethroid and neonicotinoid insecticides. This study evaluated the efficacy of the newly developed fungal biopesticide Aprehend™, containing Beauveria bassiana, against insecticide‐resistant bed bugs.RESULTSOverall mortality for the Harold Harlan (insecticide‐susceptible) strain was high (98–100%) following exposure to Aprehend™ or Suspend SC (deltamethrin). The mean survival times (MSTs) for Harold Harlan bed bugs were 5.1 days for Aprehend™ and 4.8 and 3.0 days for the low and high concentrations of Suspend SC respectively. All three strains of pyrethroid‐resistant bed bugs were susceptible to infection by B. bassiana, resulting in MSTs of <6 days (median = 4 days) and >94% overall mortality. Conversely, mortality of the three insecticide‐resistant strains after exposure to Suspend SC was only 16‐40%.CONCLUSIONThese results demonstrate that Aprehend™ is equally effective against insecticide‐susceptible and insecticide‐resistant bed bugs and could provide pest control operators with a promising new tool for control of bed bugs and insecticide resistance management. © 2017 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
c-Jun Amino-Terminal Kinase is Involved in Valproic Acid-Mediated Neuronal Differentiation of Mouse Embryonic NSCs and Neurite Outgrowth of NSC-Derived Neurons
Authors: Lu Lu , Zhou Hengxing , Pan Bin , Li Xueying , Fu Zheng , Liu Jun , Shi Zhongju , Chu Tianci , Wei Zhijian , Ning Guangzhi , Feng Shiqing 
Published: March 2017

Abstract
Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug, can induce neuronal differentiation, promote neurite extension and exert a neuroprotective effect in central nervous system (CNS) injuries; however, comparatively little is known regarding its action on mouse embryonic neural stem cells (NSCs) and the underlying molecular mechanism. Recent studies suggested that c-Jun N-terminal kinase (JNK) is required for neurite outgrowth and neuronal differentiation during neuronal development. In the present study, we cultured mouse embryonic NSCs and treated the cells with 1 mM VPA for up to 7 days. The results indicate that VPA promotes the neuronal differentiation of mouse embryonic NSCs and neurite outgrowth of NSC-derived neurons; moreover, VPA induces the phosphorylation of c-Jun by JNK. In contrast, the specific JNK inhibitor SP600125 decreased the VPA-stimulated increase in neuronal differentiation of mouse embryonic NSCs and neurite outgrowth of NSC-derived neurons. Taken together, these results suggest that VPA promotes neuronal differentiation of mouse embryonic NSCs and neurite outgrowth of NSC-derived neurons. Moreover, JNK activation is involved in the effects of VPA stimulation.
Reducing Surgery Cancellations at a Pediatric Ambulatory Surgery Center
Authors: Lee Chelsea M. , Rodgers Cheryl , Oh Albert K. , Muckler Virginia C. 
Published: March 2017

AbstractSurgery cancellations are costly and can be frustrating for patients, their families, and the surgical team. Because of the inherent nature of an ambulatory surgery center, which only performs scheduled elective procedures, surgical cancellations typically result in wasted time and resources. Pediatric surgery cancellations can be mitigated with proper preoperative screening and communication between nurses and patients’ guardians. To reduce the rate of cancellation at our pediatric ambulatory surgery center, we implemented a Nurse‐Patient Preoperative Call Log. Preoperative nurses called patients or their guardians on two separate occasions during the two weeks before surgery to review health history and instructions and answer questions about the upcoming surgery. Three months after implementing the call log, surgery cancellation rates significantly decreased from 16.8% to 8.8% (P < .05). Nurses used the call log for all patients, with 85.6% of patients receiving two calls in the two weeks before their surgery.
Viscoelastic Studies: Effective Tools for Trauma and Surgical Resuscitation Efforts
Authors: Salinas Dagoberto 
Published: March 2017

AbstractTrauma‐induced coagulopathy (TIC) is an abrupt disruption of all hemostatic components of coagulation resulting from severe tissue injury and hypoperfusion. The effective management of TIC has remained elusive to clinicians using traditional laboratory methods, challenging efforts to improve outcomes related to uncontrolled bleeding. Recent initiatives have aimed to reduce TIC‐associated morbidity and mortality, further invoking trauma experts to explore innovative modalities in the field of viscoelastic studies, such as thromboelastography (TEG) and rotational thromboelastometry (ROTEM). These tests are able to guide proper blood product administration more effectively during trauma and surgical resuscitation compared with conventional laboratory tests. Although TEG and ROTEM are similar tests, inherent differences in their features produce variation in output results. This article calls on the perioperative clinician to evaluate TEG and ROTEM tests and consider their implementation based on the benefits of their application to clinical practice.
Guideline Implementation: Energy‐Generating Devices, Part 2‐Lasers
Authors: Burlingame Byron L. 
Published: March 2017

AbstractLasers have been used in the OR for many years and are essential tools in many different types of procedures. However, laser beams that come into contact with unintended targets directly or via reflection can cause injury to patients or personnel or pose other hazards, such as fires. The new AORN “Guideline for safe use of energy‐generating devices” provides guidance on the use of all energy‐generating devices in the OR. This article focuses on key points of the guideline that address the safe use of lasers. These include the components of the laser safety program, the responsibilities of the personnel in roles specific to use of a laser, laser safety measures, and documentation of laser use. Perioperative RNs should review the complete guideline for additional information and for guidance when writing and updating policies and procedures.