bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Nickel‐Catalyzed Reductive Cross‐Coupling of (Hetero)Aryl Iodides with Fluorinated Secondary Alkyl Bromides.
Authors: Li Xuefei , Feng Zhang , Jiang Zhong‐Xing , Zhang Xingang 
Published: March 2016

AbstractThe reaction fails for trifluoromethylated tertiary alkyl bromides and gives only poor yields for trifluoromethylated primary alkyl chlorides (not shown).
ChemInform Abstract: Mild Deprotection of PMB Ethers Using tert‐Butyl Bromide.
Authors: Rival Nicolas , Albornoz Grados Arantxa , Schiavo Lucie , Colobert Francoise , Hanquet Gilles 
Published: March 2016

AbstractA mild method for the cleavage and scavenging of 4‐methoxybenzyl protecting group using tBuBr is reported.
ChemInform Abstract: Cross‐Dehydrogenative Coupling of Tertiary Amines and Terminal Alkynes Catalyzed by Copper Nanoparticles on Zeolite.
Authors: Alonso Francisco , Arroyo Adrian , Martin‐Garcia Iris , Moglie Yanina 
Published: March 2016

AbstractOxidized copper nanoparticles on sodium Y zeolite are used as a novel heterogeneous catalyst for the cross‐dehydrogenative coupling of tertiary amines and terminal alkynes.
ChemInform Abstract: Silver(I)‐Catalyzed N‐Trifluoroethylation of Anilines and O‐Trifluoroethylation of Amides with 2,2,2‐Trifluorodiazoethane.
Authors: Luo Haiqing , Wu Guojiao , Zhang Yan , Wang Jianbo 
Published: March 2016

AbstractFor the N‐trifluoroethylation of anilines, a formal N—H insertion reaction is suggested involving a Ag(I)/carbene formation and subsequent amine ligand migratory insertion.
ChemInform Abstract: Palladium‐Catalyzed Reductive Carbonylation of Aryl Halides with Iron Pentacarbonyl for Synthesis of Aromatic Aldehydes and Deuterated Aldehydes.
Authors: Iranpoor Nasser , Firouzabadi Habib , Etemadi‐Davan Elham , Rostami Abed , Rajabi Moghadam Khashayar 
Published: March 2016

AbstractA novel Pd‐catalyzed reductive carbonylation of iodoranes under phosphine‐free conditions and Fe(CO)5 as CO source is developed.
ChemInform Abstract: Disulfide‐Based Metal‐Free α‐Sulfanylation of Ketones.
Authors: Vaquer Andrea F. , Frongia Angelo , Secci Francesco , Tuveri Enrica 
Published: March 2016

AbstractA novel metal‐free proline‐catalyzed protocol is presented for the sulfanylation of cyclic and acyclic ketones by using diphenylsulfides.
ChemInform Abstract: Copper‐Catalyzed Trifluoromethylthiolation of Di(hetero)aryl‐λ3‐iodanes: Mechanistic Insight and Application to Synthesis of (Hetero)Aryl Trifluoromethyl Sulfides.
Authors: Saravanan Perumal , Anbarasan Pazhamalai 
Published: March 2016

AbstractPreliminary mechanistic investigations do not support the involvement of radicals in the reaction, rather than a Cu(I)/Cu(III) catalytic cycle involving an efficient salt metathesis between the copper complex and AgS—CF3 as indicated by temperature dependent 19F NMR spectroscopy.
ChemInform Abstract: Access to Highly Functionalized Sulfonated Cyclopentanes by Acid‐Promoted Rauhut‐Currier Reaction with Sulfinamides.
Authors: Gigant Nicolas , Drege Emmanuelle , Retailleau Pascal , Joseph Delphine 
Published: March 2016

AbstractStarting from symmetrically aryl‐ or alkyl‐substituted dienediones and sulfonamides a high‐yielding metal‐free access to sulfonated cyclopentanes with three contiguous stereocenters is developed.
ChemInform Abstract: Palladium‐Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Cyclopentanones.
Authors: Craig Robert A. , Loskot Steven A. , Mohr Justin T. , Behenna Douglas C. , Harned Andrew M. , Stoltz Brian M. 
Published: March 2016

AbstractThe scalable title reaction provides cyclopentanones with an α‐quaternary centre in often very high yields and with very high enantiomeric excesses.
ChemInform Abstract: Synthesis and Acid‐Catalyzed Cyclization of 2‐Alkenylstilbenes: A New Approach to the Substituted Indenes.
Authors: Ding Wei , Shi Xiaoxin , Lu Xia 
Published: March 2016

AbstractThe title stilbenes (II) are obtained by base‐catalyzed ring‐opening of various benzylisochromans.
ChemInform Abstract: A Simple Method for the Synthesis of Furfuryl Ketones and Furylacetic Acid Derivatives.
Authors: Chalikidi Petrakis N. , Nevolina Tatyana A. , Uchuskin Maxim G. , Abaev Vladimir T. , Butin Alexander V. 
Published: March 2016

AbstractA simple method for the synthesis of aryl furfuryl ketones (III), amides (V), and furylacetic acid esters (VII) based on the radical alkylation of furan derivatives (II) with corresponding xanthogenates is developed.
ChemInform Abstract: TfOH‐Catalyzed Domino Cycloisomerization/Hydrolytic Defluorination of 2,3‐Allenyl Perfluoroalkyl Ketones.
Authors: Xue Can , Huang Xin , Wu Shangze , Zhou Jing , Dai Jianxin , Fu Chunling , Ma Shengming 
Published: March 2016

AbstractProtons are the actual catalyst for the described reaction.
ChemInform Abstract: Nickel‐Catalyzed Direct C(sp3)—H Arylation of Aliphatic Amides with Thiophenes.
Authors: Wang Xie , Zhu Longzhi , Chen Sihai , Xu Xinhua , Au Chak‐Tong , Qiu Renhua 
Published: March 2016

AbstractThe scalable reaction is based on the chelation assistance of an N‐(quinolin‐8‐yl) group and tolerates multiple functional groups.
ChemInform Abstract: Copper‐Mediated N‐Arylation of Methyl 2‐Aminothiophene‐3‐carboxylate with Organoboron Reagents.
Authors: Rizwan Komal , Karakaya Idris , Heitz Drew , Zubair Muhammad , Rasool Nasir , Molander Gary A. 
Published: March 2016

AbstractThe desired N‐arylated 2‐amino‐thiophene derivatives (III) and (V) are obtained via Chan—Lam cross‐coupling of aminothiophene (I) with both arylboronic acids (II) and aryl trifluoroborate salts (IV).
ChemInform Abstract: γ‐Lactams and Furan Bispyrrolidines via Iodine Mediated Cyclization of Homoallylamines.
Authors: Hama Salih Mariwan A. , Male Louise , Spencer Neil , Fossey John S. 
Published: March 2016

AbstractA versatile route to 1,2,5‐trisubstituded γ‐lactams with tertiary alcohol functionality at the 3‐position, from homoallylic amine derivatives with a methyl group at the β‐position, is presented.
ChemInform Abstract: Stereoselective Formation of Chiral trans‐4‐Hydroxy‐5‐substituted 2‐pyrrolidinones: Syntheses of Streptopyrrolidine and 3‐epi‐Epohelmin A.
Authors: Si Chang‐Mei , Mao Zhuo‐Ya , Liu Yi‐Wen , Du Zhen‐Ting , Wei Bang‐Guo , Lin Guo‐Qiang 
Published: March 2016

AbstractA novel one‐pot method for the diastereoselective synthesis of trans‐4‐hydroxy‐5‐substituted 2‐pyrrolidinones via intramolecular cascade reaction of a series of Grignard reagents is presented.
ChemInform Abstract: Synthesis of α‐Enamino Esters via Cu(II)‐Promoted Dehydrogenation of α‐Amino Acid Esters: Application to the Synthesis of Polysubstituted Pyrroles.
Authors: Zhou Nini , Li Zhongle , Xie Zhixiang 
Published: March 2016

AbstractA novel and efficient approach towards α‐amino esters as synthons for polysubstituted NH pyrroles is presented.
ChemInform Abstract: Rhodium(II)‐Catalyzed Formal [3 + 2] Cycloaddition of N‐Sulfonyl‐1,2,3‐triazoles with Isoxazoles: Entry to Polysubstituted 3‐Aminopyrroles.
Authors: Lei Xiaoqiang , Li Longbo , He Yu‐Peng , Tang Yefeng 
Published: March 2016

AbstractThe method tolerates various 4‐(het)aryl substituted 1,2,3‐triazoles, but fails using 4‐alkyl substituted derivatives.
ChemInform Abstract: Combining Cycloisomerization with Trienamine Catalysis: A Regiochemically Flexible Enantio‐ and Diastereoselective Synthesis of Hexahydroindoles.
Authors: Chintalapudi V. , Galvin E. A. , Greenaway R. L. , Anderson E. A. 
Published: March 2016

AbstractVarious polysubstituted hexahydroindoles are synthesized through trienamine‐organocatalyzed cycloadditions of pyrrolidinyl dienals, prepared by palladium‐catalyzed cycloisomerization.
ChemInform Abstract: An Organocatalytic Asymmetric Friedel—Crafts Addition/Fluorination Sequence: Construction of Oxindole—Pyrazolone Conjugates Bearing Vicinal Tetrasubstituted Stereocenters.
Authors: Bao Xiaoze , Wang Baomin , Cui Longchen , Zhu Guodong , He Yuli , Qu Jingping , Song Yuming 
Published: March 2016

AbstractThe scalable highly efficient one‐pot two‐step process delivers novel oxindole‐pyrazolone adducts with two vicinal quaternary stereocenters in high yields and with excellent diastereo‐ and enantiocontrol.
ChemInform Abstract: Cuprous Oxide Catalyzed Oxidative C—C Bond Cleavage for C—N Bond Formation: Synthesis of Cyclic Imides from Ketones and Amines.
Authors: Wang Min , Lu Jianmin , Ma Jiping , Zhang Zhe , Wang Feng 
Published: March 2016

AbstractIn‐depth studies show that both α‐C—H and β‐C—H bonds adjacent to the carbonyl groups are indispensable for the C—C bond cleavage.
ChemInform Abstract: A Novel Synthesis of (E)‐1‐(2‐Hydroxyphenyl)‐3‐(1H‐indol‐3‐yl)‐prop‐2‐en‐1‐ones from Chromone‐3‐carboxylic Acid and Indoles.
Authors: Kornev Mikhail Yu. , Moshkin Vladimir S. , Sosnovskikh Vyacheslav Ya. 
Published: March 2016

AbstractTrans‐indolyl chalcones are prepared via 1,4‐nucleophilic addition including ring opening of pyrone and decarboxylation.
ChemInform Abstract: Synthesis of Functionalized Chromeno[2,3‐b]pyrrol‐4(1H)‐ones by Silver‐Catalyzed Cascade Reactions of Chromones/Thiochromones and Isocyanoacetates.
Authors: Qi Xueyu , Xiang Haoyue , Yang Chunhao 
Published: March 2016

AbstractThe reaction is assumed to proceed via nucleophilic conjugate addition of an isocyanate anion to the activated chromanone double bond followed by ring opening and subsequent pyrrole ring formation.
ChemInform Abstract: Regioselective Synthesis of 2H‐Indazoles Through Ga/Al‐ and Al‐Mediated Direct Alkylation Reactions of Indazoles.
Authors: Lin Mei‐Huey , Liu Han‐Jun , Lin Wei‐Cheng , Kuo Chung‐Kai , Chuang Tsung‐Hsun 
Published: March 2016

AbstractA very simple and efficient method for the regioselective N‐alkylation of pyrazole derivatives with alkyl and benzyl bromides is reported.
ChemInform Abstract: Iron(III) Tetranitrophthalocyanine Chloride Immobilized on Activated Carbon: Efficient, Excellent Chemoselectivity and Recyclable Catalyst for Synthesis of 2‐Substituted Benzimidazoles.
Authors: Zhao Junlong , Qiu Jun , Zhang Yaodu , Hua Chengwen , Gou Xiaofeng , Chen Bang 
Published: March 2016

AbstractThe coupling of o‐phenylenediamine with various aldehydes affording the title benzimidazoles is easy, short, and environmentally friendly.
ChemInform Abstract: Synthesis of 5‐Substituted 1H‐Tetrazoles Using a Recyclable Heterogeneous Nanonickel Ferrite Catalyst.
Authors: Abrishami Fatemeh , Ebrahimikia Maryam , Rafiee Fatemeh 
Published: March 2016

AbstractAn efficient approach to 5‐substituted 1H‐tetrazoles via nanonickel ferrite catalyzed [2+3] cycloaddition of sodium azide with nitriles is presented.
ChemInform Abstract: B(C6F5)3 as Versatile Catalyst: An Efficient and Mild Protocol for the One‐Pot Synthesis of Functionalized Piperidines and 2‐Substituted Benzimidazole Derivatives.
Authors: Prajapti Santosh Kumar , Nagarsenkar Atulya , Guggilapu Sravanthi Devi , Babu Bathini Nagendra 
Published: March 2016

AbstractOptimized conditions allow the diastereoselective one‐pot synthesis of highly functionalized piperidines via tandem reactions of acetoacetic esters, aldehydes, and amines.
ChemInform Abstract: Enantioselective Synthesis of N‐PMP‐1,2‐Dihydropyridines via Formal [4 + 2] Cycloaddition Between Aqueous Glutaraldehyde and Imines.
Authors: Ramaraju Panduga , Mir Nisar A. , Singh Deepika , Gupta Vivek K. , Kant Rajni , Kumar Indresh 
Published: March 2016

AbstractThe two‐step, one‐pot procedure involves an amino‐catalytic direct Mannich reaction/cyclization sequence followed by an IBX‐mediated chemo‐ and regioselective oxidation.
ChemInform Abstract: Selective Remote C—H Sulfonylation of Aminoquinolines with Arylsulfonyl Chlorides via Copper Catalysis.
Authors: Liang Hong‐Wen , Jiang Kun , Ding Wei , Yuan Yi , Shuai Li , Chen Ying‐Chun , Wei Ye 
Published: March 2016

AbstractCopper‐catalyzed direct C—H bond sulfonylation of aminoquinolines using commercially available and inexpensive arylsulfonyl chlorides as the sulfonylation reagents is described.
ChemInform Abstract: Synthesis of N‐Methyl‐5,6‐dihydrobenzo[c]phenanthridine and Its sp3 C(6)—H Bond Functionalization via Oxidative Cross‐Dehydrogenative Coupling Reactions.
Authors: Romo‐Perez Adriana , Miranda Luis D. , Garcia Abraham 
Published: March 2016

AbstractA novel three‐step sequence for the synthesis of benzophenanthridine (VI) is presented.
ChemInform Abstract: Microwave Assisted Synthesis of Disubstituted Imidazo[1,2‐a]pyridine‐3‐carboxylic Acid Esters
Authors: Liu Ming‐liang , Zhang Qiu‐rong , Li Lin‐hu , Wu Zhao‐yang , Li Zhuo‐rong , Guo Hui‐yuan 
Published: March 2016

Abstractby condensation of 2‐aminopyridines and ethyl 2‐halogenated acetoacetates
ChemInform Abstract: The Construction of 3‐Methyl‐4‐arylpiperidines via a trans‐Perhydroindolic Acid‐Catalyzed Asymmetric Aza‐Diels—Alder Reaction.
Authors: An Qianjin , Shen Jiefeng , Butt Nicholas , Liu Delong , Liu Yangang , Zhang Wanbin 
Published: March 2016

AbstractFused heterocycles bearing multiple contiguous stereocenters are obtained with high enantioselectivity via trans‐perhydroindolic acid‐catalyzed asymmetric aza‐Diels—Alder reaction of isothiazole or oxathiazine derivatives and propanal.
ChemInform Abstract: Synthesis of 4,7‐Dihydro[1,2,4]triazolo‐[1,5‐a]pyrimidine‐6‐sulfonamide Derivatives
Authors: Kolosov Maksim A. , Al‐Ogaili Muataz J. K. , Kulyk Olesia G. , Orlov Valeriy D. 
Published: March 2016

Abstractvia three‐component condensation of 1‐(1‐piperidinylsulfonyl)acetones, aromatic aldehydes, and 3‐amino‐1,2,3‐triazoles
ChemInform Abstract: Scalable Synthesis of Piperazines Enabled by Visible‐Light Irradiation and Aluminum Organometallics.
Authors: Suarez‐Pantiga Samuel , Colas Kilian , Johansson Magnus J. , Mendoza Abraham 
Published: March 2016

AbstractA rapid, scalable, and stereoselective assembly of multifunctional piperazines through a [3+3] coupling of azomethine ylides is developed.
ChemInform Abstract: Oxidant‐Free Au(I)‐Catalyzed Halide Exchange and C(sp2)—O Bond Forming Reactions.
Authors: Serra Jordi , Whiteoak Christopher J. , Acuna‐Pares Ferran , Font Marc , Luis Josep M. , Lloret‐Fillol Julio , Ribas Xavi 
Published: March 2016

AbstractThe first examples of oxidant‐free Au(I)‐catalyzed halide exchange and halide‐oxygen exchange reactions are described.
ChemInform Abstract: Stereoselective Construction of Bridged trans‐Aza‐Bicyclo[7/6,3/2,1]alkenyl Imines Through Ring Expansion Aza‐Cope Rearrangement.
Authors: Shen Mei‐Hua , Xu Ke , Sun Chu‐Han , Xu Hua‐Dong 
Published: March 2016

AbstractUnprecedented bridged bicyclic amidines are obtained through a highly stereoselective ketenimine formation/cyclization/aza‐Cope rearrangement cascade.
ChemInform Abstract: Ligand‐Controlled Regiodivergent Copper‐Catalyzed Alkylboration of Alkenes.
Authors: Su Wei , Gong Tian‐Jun , Lu Xi , Xu Meng‐Yu , Yu Chu‐Guo , Xu Zheng‐Yang , Yu Hai‐Zhu , Xiao Bin , Fu Yao 
Published: March 2016

AbstractFollowing subtle differences in the ligand structure [cf.
ChemInform Abstract: Silver(I)‐Catalyzed Diastereoselective Synthesis of anti‐1,2‐Hydroxyboronates.
Authors: Joannou Matthew V. , Moyer Brandon S. , Goldfogel Matthew J. , Meek Simon J. 
Published: March 2016

AbstractA wide range of aryl, alkenyl, alkyl aldehydes is used for the anti‐selective addition reactions with various 1,1‐diborylalkanes affording the title boronates.
ChemInform Abstract: Catalytic Borylation Using an Air‐Stable Zinc Boryl Reagent: Systematic Access to Elusive Acylboranes.
Authors: Campos Jesus , Aldrige Simon 
Published: March 2016

AbstractVarious aryl, vinyl, and benzylic bromides are borylated using a nucleophilic borylzinc reagent as efficient boron source under mild reaction conditions.
ChemInform Abstract: Silver‐Catalyzed Direct Regioselective Phosphonation of Thiazolo[3,2‐b]‐1,2,4‐triazoles with Dialkyl Phosphites.
Authors: Liu Wenjie , Wang Shaohua , Li Ziying , Huang Yanling , Li Shenghao , Wang Anda 
Published: March 2016

AbstractAn efficient hydrogenative cross‐coupling reaction for a direct phosphonation with dialkyl phosphites furnishes the products in moderate to good yields.
ChemInform Abstract: Two New Humulanolides from the Roots of Cynanchum wilfordii.
Authors: Li Jin‐Long , Fu Yan , Zhang Hai‐Yan , Zhao Wei‐Min 
Published: March 2016

AbstractTwo humulanolides with a bicyclo[6.3.0]undecane core and an adjoining butyrolactone moiety, named wilfolides A (I) and B (II), are isolated and their absolute configurations are confirmed by X‐ray crystallography.
ChemInform Abstract: Three Solvent‐Free Catalytic Approaches to the Acetal Functionalization of Carbohydrates and Their Applicability to One‐Pot Generation of Orthogonally Protected Building Blocks.
Authors: Traboni Serena , Bedini Emiliano , Giordano Maddalena , Iadonisi Alfonso 
Published: March 2016

AbstractThree alternative approaches for the selective acetalization of carbohydrates and polyols under mildly acidic, solvent‐free conditions are developed.
ChemInform Abstract: Foxo3a Inhibitors of Microbial Origin, JBIR‐141 and JBIR‐142.
Authors: Kawahara Teppei , Kagaya Noritaka , Masuda Yuichi , Doi Takayuki , Izumikawa Miho , Ohta Kumiko , Hirao Atsushi , Shin‐ya Kazuo 
Published: March 2016

AbstractTitle compounds (I) and (II) are isolated from soil‐derived Streptomyces sp.
ChemInform Abstract: Long Persistent Composite Phosphor CaAl2O4:Eu2+,Nd3+/Y3 Al5O12:Ce3+: A Novel Strategy to Tune the Colors of Persistent Luminescence.
Authors: Chen Wenbo , Wang Yuhua , Zeng Wei , Han Shaochun , Li Gen , Guo Haijie , Li Yanyan , Qiang Qinping 
Published: March 2016

AbstractThe phosphor CaAl2O4:0.125%Eu2+,0.25%Nd3+ is synthesized by reaction of stoichiometric mixtures of CaCO3, Al2O3, Eu2O3, Nd2O3, and a 3% excess of H3BO3 as a flux (5% H2/95% N2 stream, 1400 °C, 4 h).
ChemInform Abstract: Recent Advances in Iron Complexes as Potential Anticancer Agents
Authors: Wani Waseem A. , Baig Umair , Shreaz Sheikh , Shiekh Rayees Ahmad , Iqbal Prince Firdous , Jameel Ehtesham , Ahmad Akil , Mohd‐Setapar Siti Hamidah , Mushtaque Md. , Ting Hun Lee 
Published: March 2016

AbstractReview: 199 refs.
ChemInform Abstract: Coumarin Heterocyclic Derivatives: Chemical Synthesis and Biological Activity
Authors: Medina Fernanda G. , Marrero Joaquin G. , Macias‐Alonso Mariana , Gonzalez Magdalena C. , Cordova‐Guerrero Ivan , Teissier Garcia Ariana G. , Osegueda‐Robles Soraya 
Published: March 2016

AbstractReview: [212 refs.
ChemInform Abstract: Efavirenz a Nonnucleoside Reverse Transcriptase Inhibitor of First‐Generation: Approaches Based on Its Medicinal Chemistry
Authors: Bastos Monica M. , Costa Carolina C.P. , Bezerra Talitha C. , da Silva Fernando de C. , Boechat Nubia 
Published: March 2016

AbstractReview: 114 refs.
Neue Methoden der laserbasierten Gasanalytik
Authors: Lambrecht Armin , Bolwien Carsten , Herbst Johannes , Kühnemann Frank , Sandfort Vincenz , Wolf Sebastian 
Published: March 2016

AbstractLaser haben durch die Fortschritte in der Herstellung, Qualität und breiten Anwendbarkeit erfolgreich Einzug die optische Online‐ und Inline‐Prozessanalysentechnik gehalten. Es wird gezeigt, welche Möglichkeiten sich durch den Einsatz von laserbasierten Methoden für die Gasanalytik ergeben. Dies wird anhand von Beispielen aus der Infrarotspektroskopie und Raman‐Spektroskopie demonstriert. Mit der Raman‐Spektroskopie in hohlen photonischen Kristallfasern lassen sich geringe Gaskonzentrationen mit Messzeiten im Sekundenbereich detektieren. Mit Quantenkaskadenlasern können Methanemissionen im Spurenbereich aus der Ferne nachgewiesen werden und mithilfe von Lasern und nichtlinear‐optischen Komponenten lassen sich hochempfindliche ungekühlte Infrarotdetektoren für die Gasanalyse realisieren.
Risk‐based process system monitoring using self‐organizing map integrated with loss functions
Authors: Yu Hongyang , Khan Faisal , Garaniya Vikram 
Published: March 2016

AbstractThe conventional dynamic risk assessment technique does not consider the effect of nonlinear interactions among process variables in its operational risk estimation. Thus, this type of technique fails to provide a realistic estimation of the operational risk of complex industrial processes. To address this issue, a multivariate risk‐based process monitoring technique is proposed. This technique takes advantage of the powerful nonlinear dimensionality reduction and visualization power of the self‐organizing map to identify the origin and propagation path of the fault. Through integration with the inverted normal loss function, a robust estimation of the hazard potential and operational risk of process operations can be achieved. The proposed technique is tested with two fault conditions in the benchmark Tennessee Eastman chemical process. The results show promising performance.
Clinical and treatment factors determining long‐term outcomes for adult survivors of childhood low‐grade glioma: A population‐based study
Authors: Krishnatry Rahul , Zhukova Nataliya , Guerreiro Stucklin Ana S. , Pole Jason D. , Mistry Matthew , Fried Iris , Ramaswamy Vijay , Bartels Ute , Huang Annie , Laperriere Normand , Dirks Peter , Nathan Paul C. , Greenberg Mark , Malkin David , Hawkins Cynthia , Bandopadhayay Pratiti , Kieran Mark W. , Manley Peter E. , Bouffet Eric , Tabori Uri 
Published: March 2016

BACKGROUNDThe determinants of outcomes for adult survivors of pediatric low‐grade glioma (PLGG) are largely unknown.METHODSThis study collected population‐based follow‐up information for all PLGG patients diagnosed in Ontario, Canada from 1985 to 2012 (n = 1202) and determined factors affecting survival. The impact of upfront radiation treatment on overall survival (OS) was determined for a cohort of Ontario patients and an independent reference cohort from the Surveillance, Epidemiology, and End Results database.RESULTSAt a median follow‐up of 12.73 years (range, 0.02‐33 years), only 93 deaths (7.7%) were recorded, and the 20‐year OS rate was 90.1% ± 1.1%. Children with neurofibromatosis type 1 had excellent survival and no tumor‐related deaths during adulthood. Adverse risk factors included pleomorphic xanthoastrocytoma (P < .001) and a thalamic location (P < .001). For patients with unresectable tumors surviving more than 5 years after the diagnosis, upfront radiotherapy was associated with an approximately 3‐fold increased risk of overall late deaths (hazard ratio [HR], 3.3; 95% confidence interval [CI], 1.6‐6.6; P = .001) and an approximately 4‐fold increased risk of tumor‐related deaths (HR, 4.4; 95% CI, 1.3‐14.6; P = .013). In a multivariate analysis, radiotherapy was the most significant factor associated with late all‐cause deaths (HR, 3.0; 95% CI, 1.3‐7.0; P = .012) and tumor‐related deaths (HR, 4.4; 95% CI, 1.3‐14.6; P = 0.014). A similar association between radiotherapy and late deaths was observed in the independent reference cohort (P < .001). In contrast to early deaths, late mortality was associated not with PLGG progression but rather with tumor transformation and non‐oncological causes.CONCLUSIONSThe course of PLGG is associated with excellent long‐term survival, but this is hampered by increased delayed mortality in patients receiving upfront radiotherapy. These observations should be considered when treatment options are being weighed for these patients. Cancer 2016;122:1261–9. © 2016 American Cancer Society.