bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indoor air pollution and cognitive function among older Mexican adults
Authors: Saenz Joseph L , Wong Rebeca , Ailshire Jennifer A 
Published: December 2017

BackgroundA growing body of research suggests exposure to high levels of outdoor air pollution may negatively affect cognitive functioning in older adults, but less is known about the link between indoor sources of air pollution and cognitive functioning. We examine the association between exposure to indoor air pollution and cognitive function among older adults in Mexico, a developing country where combustion of biomass for domestic energy remains common.MethodData come from the 2012 Wave of the Mexican Health and Aging Study. The analytic sample consists of 13 023 Mexican adults over age 50. Indoor air pollution is assessed by the reported use of wood or coal as the household’s primary cooking fuel. Cognitive function is measured with assessments of verbal learning, verbal recall, attention, orientation and verbal fluency. Ordinary least squares regression is used to examine cross-sectional differences in cognitive function according to indoor air pollution exposure while accounting for demographic, household, health and economic characteristics.ResultsApproximately 16% of the sample reported using wood or coal as their primary cooking fuel, but this was far more common among those residing in the most rural areas (53%). Exposure to indoor air pollution was associated with poorer cognitive performance across all assessments, with the exception of verbal recall, even in fully adjusted models.ConclusionsIndoor air pollution may be an important factor for the cognitive health of older Mexican adults. Public health efforts should continue to develop interventions to reduce exposure to indoor air pollution in rural Mexico.
Level of moderate-intensity leisure-time physical activity and reduced mortality in middle-aged and elderly Chinese
Authors: Liu Ying , Wen Wanqing , Gao Yu-Tang , Li Hong-Lan , Yang Gong , Xiang Yong-Bing , Shu Xiao-Ou , Zheng Wei 
Published: December 2017

BackgroundFew studies have prospectively evaluated the association of leisure-time physical activity (LTPA) with mortality in Asians, who are more susceptible to insulin resistance than their Caucasian counterparts.MethodsData from two large prospective cohort studies conducted in Shanghai were evaluated. After excluding participants who had a history of cancer, coronary heart disease or stroke at baseline, or who died within the first 3 years after study enrolment, 53 839 men and 66 888 women, followed for an average of 9.2 and 14.7 years, respectively, remained for the study.ResultsCompared with those who reported no exercise, a reduction in mortality with an HR of 0.86 (95% CI 0.80 to 0.93) was observed in those who regularly engage in moderate-intensity LTPA, even those who reported an LTPA level lower than the minimum amount recommended by the current physical activity guidelines (150 min or 7.5 metabolic equivalent hours per week). The association between moderate-intensity exercise and mortality followed a dose–response pattern until the amount of LTPA reached 3–5 times the recommended minimum level. A similar pattern of association was observed for cause-specific mortality due to cardiovascular disease (CVD), cancer or other causes.ConclusionRegular participation in moderate-intensity LTPA was associated with reduced mortality, particularly CVD mortality, even when the LTPA was below the minimum level recommended by current guidelines. Increasing the amount of moderate-intensity LTPA was associated with further risk reduction up to a potential threshold of 3–5 times the recommended minimum.
Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies
Authors: Sveen Anita , Bruun Jarle , Eide Peter W. , Eilertsen Ina A. , Ramirez Lorena , Murumägi Astrid , Arjama Mariliina , Danielsen Stine A. , Kryeziu Kushtrim , Elez Elena , Tabernero Josep , Guinney Justin , Palmer Hector G. , Nesbakken Arild , Kallioniemi Olli , Dienstmann Rodrigo , Lothe Ragnhild A. 
Published: December 2017

Abstract
Purpose: Response to standard oncologic treatment is limited in colorectal cancer. The gene expression–based consensus molecular subtypes (CMS) provide a new paradigm for stratified treatment and drug repurposing; however, drug discovery is currently limited by the lack of translation of CMS to preclinical models.
Experimental Design: We analyzed CMS in primary colorectal cancers, cell lines, and patient-derived xenografts (PDX). For classification of preclinical models, we developed an optimized classifier enriched for cancer cell–intrinsic gene expression signals, and performed high-throughput in vitro drug screening (n = 459 drugs) to analyze subtype-specific drug sensitivities.
Results: The distinct molecular and clinicopathologic characteristics of each CMS group were validated in a single-hospital series of 409 primary colorectal cancers. The new, cancer cell–adapted classifier was found to perform well in primary tumors, and applied to a panel of 148 cell lines and 32 PDXs, these colorectal cancer models were shown to recapitulate the biology of the CMS groups. Drug screening of 33 cell lines demonstrated subtype-dependent response profiles, confirming strong response to EGFR and HER2 inhibitors in the CMS2 epithelial/canonical group, and revealing strong sensitivity to HSP90 inhibitors in cells with the CMS1 microsatellite instability/immune and CMS4 mesenchymal phenotypes. This association was validated in vitro in additional CMS-predicted cell lines. Combination treatment with 5-fluorouracil and luminespib showed potential to alleviate chemoresistance in a CMS4 PDX model, an effect not seen in a chemosensitive CMS2 PDX model.
Conclusions: We provide translation of CMS classification to preclinical models and uncover a potential for targeted treatment repurposing in the chemoresistant CMS4 group. Clin Cancer Res; 24(4); 794–806. ©2017 AACR.
Inhibiting Nuclear Phospho-Progesterone Receptor Enhances Antitumor Activity of Onapristone in Uterine Cancer
Authors: Huang Yan , Hu Wei , Huang Jie , Shen Fangrong , Sun Yunjie , Ivan Cristina , Pradeep Sunila , Dood Robert , Haemmerle Monika , Jiang Dahai , Mangala Lingegowda S. , Noh Kyunghee , Hansen Jean M. , Dalton Heather J. , Previs Rebecca A. , Nagaraja Archana S. , McGuire Michael , Jennings Nicholas B. , Broaddus Russell , Coleman Robert L. , Sood Anil K. 
Published: December 2017

Abstract
Although progesterone receptor (PR)–targeted therapies are modestly active in patients with uterine cancer, their underlying molecular mechanisms are not well understood. The clinical use of such therapies is limited because of the lack of biomarkers that predict response to PR agonists (progestins) or PR antagonists (onapristone). Thus, understanding the underlying molecular mechanisms of action will provide an advance in developing novel combination therapies for cancer patients. Nuclear translocation of PR has been reported to be ligand-dependent or -independent. Here, we identified that onapristone, a PR antagonist, inhibited nuclear translocation of ligand-dependent or -independent (EGF) phospho-PR (S294), whereas trametinib inhibited nuclear translocation of EGF-induced phospho-PR (S294). Using orthotopic mouse models of uterine cancer, we demonstrated that the combination of onapristone and trametinib results in superior antitumor effects in uterine cancer models compared with either monotherapy. These synergistic effects are, in part, mediated through inhibiting the nuclear translocation of EGF-induced PR phosphorylation in uterine cancer cells. Targeting MAPK-dependent PR activation with onapristone and trametinib significantly inhibited tumor growth in preclinical uterine cancer models and is worthy of further clinical investigation. Mol Cancer Ther; 17(2); 464–73. ©2017 AACR.
Antitumor Activity of Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor, in ETV6-NTRK3–Positive Acute Myeloid Leukemia
Authors: Smith Kristen M. , Fagan Patrick C. , Pomari Elena , Germano Giuseppe , Frasson Chiara , Walsh Colin , Silverman Ian , Bonvini Paolo , Li Gang 
Published: December 2017

Abstract
Activation of tropomyosin receptor kinase (TRK) family tyrosine kinases by chromosomal rearrangement has been shown to drive a wide range of solid tumors and hematologic malignancies. TRK fusions are actionable targets as evidenced by recent clinical trial results in solid tumors. Entrectinib (RXDX-101) is an investigational, orally available, CNS-active, highly potent, and selective kinase inhibitor against TRKA/B/C, ROS1, and ALK kinase activities. Here, we demonstrate that TRK kinase inhibition by entrectinib selectively targets preclinical models of TRK fusion–driven hematologic malignancies. In acute myelogenous leukemia (AML) cell lines with endogenous expression of the ETV6–NTRK3 fusion gene, entrectinib treatment blocked cell proliferation and induced apoptotic cell death in vitro with subnanomolar IC50 values. Phosphorylation of the ETV6–TRKC fusion protein and its downstream signaling effectors was inhibited by entrectinib treatment in a dose-dependent manner. In animal models, entrectinib treatment at clinically relevant doses resulted in tumor regression that was accompanied by elimination of residual cancer cells from the bone marrow. Our preclinical data demonstrate the potential of entrectinib as an effective treatment for patients with TRK fusion–driven AML and other hematologic malignancies. Mol Cancer Ther; 17(2); 455–63. ©2017 AACR.
SNRK (Sucrose Nonfermenting 1-Related Kinase) Promotes Angiogenesis In Vivo
Authors: Lu Qiulun , Xie Zhonglin , Yan Chenghui , Ding Ye , Ma Zejun , Wu Shengnan , Qiu Yu , Cossette Stephanie M. , Bordas Michelle , Ramchandran Ramani , Zou Ming-Hui 
Published: December 2017

Objective—
SNRK (sucrose nonfermenting 1-related kinase) is a novel member of the AMPK (adenosine monophosphate-activated protein kinase)-related superfamily that is activated in the process of angiogenesis. Currently, little is known about the function of SNRK in angiogenesis in the physiological and pathological conditions.

Approach and Results—

In this study, in
Snrk
global heterozygous knockout mice, retina angiogenesis and neovessel formation after hindlimb ischemia were suppressed. Consistently, mice with endothelial cell (EC)-specific
Snrk
deletion exhibited impaired retina angiogenesis, and delayed perfusion recovery and exacerbated muscle apoptosis in ischemic hindlimbs, compared with those of littermate wide-type mice. Endothelial SNRK expression was increased in the extremity vessel samples from nonischemic human. In ECs cultured in hypoxic conditions, HIF1α (hypoxia inducible factor 1α) bound to the
SNRK
promoter to upregulate
SNRK
expression. In the nuclei of hypoxic ECs, SNRK complexed with SP1 (specificity protein 1), and together, they bound to an SP1-binding motif in the ITGB1 (β1 integrin) promoter, resulting in enhanced ITGB1 expression and promoted EC migration. Furthermore,
SNRK
or
SP1
deficiency in ECs ameliorated hypoxia-induced ITGB1 expression and, consequently, inhibited EC migration and angiogenesis.

Conclusions—
Taken together, our data have revealed that SNRK/SP1-ITGB1 signaling axis promotes angiogenesis in vivo.
Near-Field Ultrasound Imaging During Radiofrequency Catheter Ablation
Authors: Haines David E. , Wright Matthew , Harks Erik , Deladi Szabolcs , Fokkenrood Steven , Brink Rob , Belt Harm , Kolen Alexander F. , Mihajlovic Nenad , Zuo Fei , Rankin Darrell , Stoffregen William , Cockayne Debra , Cefalu Joseph 
Published: December 2017

Background
Safe and successful radiofrequency catheter ablation depends on creation of transmural lesions without collateral injury to contiguous structures. Near-field ultrasound (NFUS) imaging through transducers in the tip of an ablation catheter may provide important information about catheter contact, wall thickness, and ablation lesion formation.

Methods and Results

NFUS imaging was performed using a specially designed open-irrigated radiofrequency ablation catheter incorporating 4 ultrasound transducers. Tissue/phantom thickness was measured in vitro with varying contact angles. In vivo testing was performed in 19 dogs with NFUS catheters positioned in 4 chambers. Wall thickness measurements were made at 222 sites (excluding the left ventricle) and compared with measurements from intracardiac echocardiography. Imaging was used to identify the epicardium with saline infusion into the pericardial space at 39 sites. In vitro, the measured exceeded actual tissue/phantom thickness by 13% to 20%. In vivo, NFUS reliably visualized electrode-tissue contact, but sensitivity of epicardial imaging was 92%. The chamber wall thickness measured by NFUS correlated well with intracardiac echocardiography (
r
=0.86;
P
<0.0001). Sensitivity of lesion identification by NFUS was 94% for atrial and 95% for ventricular ablations. NFUS was the best parameter to predict lesion depth in right and left ventricle (
r
=0.47;
P
<0.0001; multiple regression
P
=0.0025). Lesion transmurality was correctly identified in 87% of atrial lesions.

Conclusions
NFUS catheter imaging reliably assesses electrode-tissue contact and wall thickness. Its use during radiofrequency catheter ablation may allow the operator to assess the depth of ablation required for transmural lesion formation to optimize power delivery.
Change in Cognitive Function in the Month After Hospitalization for Acute Coronary Syndromes
Authors: Saczynski Jane S. , McManus David D. , Waring Molly E. , Lessard Darleen , Anatchkova Milena D. , Gurwitz Jerry H. , Allison Jeroan , Ash Arlene S. , McManus Richard H. , Parish David C. , Goldberg Robert J. , Kiefe Catarina I. 
Published: December 2017

Background—
Cognitive function is often impaired during hospitalization, but whether this impairment resolves or persists after discharge is unknown.

Methods and Results—
We enrolled (April 2011–May 2013) and interviewed during hospitalization and 1-month post-discharge 1521 nondemented acute coronary syndrome survivors enrolled in TRACE (Transitions, Risks and Actions in Coronary Events). Cognitive function was assessed using the Telephone Interview of Cognitive Status (range: 0–41) at both time points. Patients reported demographic and psychosocial characteristics and medical records were abstracted. Using the Telephone Interview of Cognitive Status cut point of ≤28, we defined 4 groups of cognitive change based on cognitive status during hospitalization and 1 month later: consistently impaired, transiently impaired, newly impaired, and consistently nonimpaired. Characteristics associated with cognitive change categories were examined using multinomial logistic regression. Participants were 67% male, 84% non-Hispanic white, with mean age±SD 62±11 years; 16% (n=237) were cognitively impaired during hospitalization, and 11% (n=174) were impaired 1 month after discharge. Overall, 80% were consistently nonimpaired, 9% transiently impaired, 7% consistently impaired, and 4% newly impaired. Lower education level, minority status, low health literacy and numeracy, and higher severity of disease were independently associated with cognitive impairment during and after hospitalization. Male sex was associated with increased risk of cognitive impairment after hospital discharge.

Conclusions—
Cognitive function changes during the transition from hospital to home after acute coronary syndrome are less favorable for men and those with psychosocial vulnerability. Assessing cognitive status both in hospital and post-discharge is important for detecting patients who could benefit from tailored transitional care including early follow-up and booster discharge instructions.
Facebook jako źródło wykluczenia społecznego ery Web 2.0
Authors: Sobczak Katarzyna Natalia 
Published: December 2017

Facebook as a new source of social exclusion in Web 2.0 eraSocial life in the 21st century is no longer composed simply of direct communication but also of technology-mediated one. Moreover, these two patterns of communication are both equally important. In such cyberreal world the Internet not only is the equalizing force which reduces traditionally understood social divisions but also offers additional opportunities and creates a new kind of social exclusion – the social network exclusion. The main aim of this article is an analysis of the mechanisms created by Facebook that exclude and limit the access to its content, as compared with the traditional forms of social life and exclusion. Facebook jako źródło wykluczenia społecznego ery Web 2.0W XXI wieku życie społeczne opiera się już nie tylko na komunikacji bezpośredniej, ale jest również zapośredniczone cyfrowo, przy czym obie te sfery są sobie równoważne. W tak rozumianym cyberrealnym świecie internet nie jest wyłącznie siłą zacierającą tradycyjne podziały społeczne, lecz oferuje techniczne możliwości i sprzyja tworzeniu nowego typu wykluczenia – społecznościowego. Głównym celem niniejszego artykułu jest analiza portalu Facebook pod kątem mechanizmów wykluczających i ograniczających dostęp do zgromadzonych w serwisie treści w kontekście tradycyjnych form życia i wykluczenia społecznego.
Extension and Contraction
Authors: Starkweather David , Winold Helga U. 
Published: December 2017

David Starkweather is the cellist on the faculty of the University of Georgia. He grew up near San Francisco, then attended the Eastman School of Music. This was followed by four years of graduate work at the State University of New York at Stony Brook, where he studied cello with Bernard Greenhouse. In 1985, Starkweather spent half a year in Switzerland for intensive work with Pierre Fournier, earning the famous French cellist's accolade as “one of the best cellists of his generation.” He was awarded a certificate of merit as a semi-finalist in the 1986 Tchaikovsky Competition. Starkweather has been featured on the National Public Radio show Performance Today and in. a PBS one-hour recital program televised nationwide. A review in the Atlanta Constitution praised his “sensitive phrasing and Starkweather's obvious technical facility.” His previous articles for AST were “Methods of Shifting” (Winter 1988) and “Choice of Fingerings” (Summer 1990).
Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation
Authors: Gupta Dhanak , Grant David M , Zakir Hossain Kazi M , Ahmed Ifty , Sottile Virginie 
Published: December 2017

Mesenchymal stem cells play a vital role in bone formation process by differentiating into osteoblasts, in a tissue that offers not a flat but a discontinuous three-dimensional (3D) topography in vivo. In order to understand how geometry may be affecting mesenchymal stem cells, this study explored the influence of 3D geometry on mesenchymal stem cell-fate by comparing cell growth, viability and osteogenic potential using monolayer (two-dimensional, 2D) with microsphere (3D) culture systems normalised to surface area. The results suggested lower cell viability and reduced cell growth in 3D. Alkaline phosphatase activity was higher in 3D; however, both collagen and mineral deposition appeared significantly lower in 3D, even after osteogenic supplementation. Also, there were signs of patchy mineralisation in 3D with or without osteogenic supplementation as early as day 7. These results suggest that the convex surfaces on microspheres and inter-particulate porosity may have led to variable cell morphology and fate within the 3D culture. This study provides deeper insights into geometrical regulation of mesenchymal stem cell responses applicable for bone tissue engineering.
Managing cancer care through service delivery networks: The role of professional collaboration in two European cancer networks
Authors: Prades Joan , Morando Verdiana , Tozzi Valeria D , Verhoeven Didier , Germà Jose R , Borras Josep M 
Published: December 2017

Background The study examines two meso-strategic cancer networks, exploring to what extent collaboration can strengthen or hamper network effectiveness. Unlike macro-strategic networks, meso-strategic networks have no hierarchical governance structures nor are they institutionalised within healthcare services’ delivery systems. This study aims to analyse the models of professional cooperation and the tools developed for managing clinical practice within two meso-strategic, European cancer networks. Methods Multiple case study design based on the comparative analysis of two cancer networks: Iridium, in Antwerp, Belgium and the Institut Català d’Oncologia in Catalonia, Spain. The case studies applied mixed methods, with qualitative research based on semi-structured interviews ( n = 35) together with case-site observation and material collection. Results The analysis identified four levels of collaborative intensity within medical specialties as well as in multidisciplinary settings, which became both platforms for crosscutting clinical work between hubs’ experts and local care teams and the levers for network-based tools development. The organisation of clinical practice relied on professional-based cooperative processes and tiers, lacking vertical integration mechanisms. Conclusions The intensity of professional linkages largely shaped the potential of meso-strategic cancer networks to influence clinical practice organisation. Conversely, the introduction of managerial techniques or network governance structures, without introducing vertical hierarchies, was found to be critical solutions.
Endovascular Treatment of Thromboangiitis Obliterans (Buerger’s Disease)
Authors: Modaghegh Mohammad-Hadi S. , Hafezi Shahab 
Published: December 2017

Purpose: When critical limb ischemia (CLI) occurs in patients with thromboangiitis obliterans (TAO) or Buerger’s disease, smoking cessation alone may be insufficient to relieve rest pain and promote wound healing. Accordingly, adjunctive measures are warranted to restore adequate blood flow required for limb salvage. This study aimed to evaluate the feasibility and efficacy of percutaneous transluminal angioplasty (PTA) for the treatment of patients with TAO and CLI. In addition, a review of the literature on endovascular management of TAO is included. Methods: Between April 2012 and June 2017, all patients with TAO and CLI who underwent PTA were studied retrospectively. Patient demographics, presentation, procedural details, and clinical response were recorded. Patients were monitored at 1 week, 1, 2, 3, and 6 months after revascularization and at least every 6 months thereafter. Results: Thirteen patients with TAO and CLI, who presented with rest pain only (n = 1), ischemic ulcer (n = 4), or gangrene (n = 8) underwent endovascular interventions with primary and assisted primary technical success of 85% and 92%, respectively. A below-knee amputation was eventually done in the only patient with technical failure (limb salvage rate: 92%). Following the procedures, 11 patients had clinical response, one of whom also received intra-arterial vasodilator to achieve complete symptom relief. The other patient who failed PTA underwent a successful lumbar sympathectomy. In addition, all ulcers healed and eight minor amputations were performed due to already established gangrene. During follow-up (mean: 19.4 months), four patients needed reintervention. Patients who continued to smoke experienced more severe ischemia ( P = .017) and were more likely to require reintervention ( P = .009). Conclusion: Percutaneous transluminal angioplasty can be considered as a technically feasible and potentially effective treatment for patients with TAO and CLI, as well as a last resort for limb salvage when other options have failed. However, reintervention may be required, especially in patients who continue smoking.