bluuebunny/crossref_metadata_2025_split huggingface dataset:
Filaments for 3D Printing of Iridescent Structural Colors
Authors: Siegwardt Lukas , Hemkemeier Georg , Gallei Markus 
Published: October 2024

AbstractInspired by nature, this work presents a scalable method to produce opalescent 3D printing filaments with angle‐dependent structural color. Compared to conventional colorants, these colors provide a more vivid appearance, possess the ability to dynamically change in response to alterations of illumination, and may feature superior longevity as well as durability. Particle synthesis via emulsion polymerization in starved‐feed mode is utilized to achieve a tailored core–shell particle architecture. During processing, the thermoplastic polyacrylate‐based shells form a continuous matrix, wherein the pristine polystyrene cores self‐assemble. The colloidal ordered structure thus formed selectively scatters light according to Bragg's law. Adjusting particle size makes the perceived colors easily tunable over the visible spectrum. The filaments are printable on entry‐level printers with comparable settings to commercial filaments and state‐of‐the‐art print quality. With this work, sustainable 3D printing of iridescent objects with a novel and superior coloration strategy becomes possible for everyone – from hobbyists over customized goods and industrial prototypes to serial production.
Biodegradable Substrates for Rigid and Flexible Circuit Boards: A Review
Authors: Dušek Karel , Koc Daniel , Veselý Petr , Froš Denis , Géczy Attila 
Published: October 2024

AbstractBiodegradable materials represent a promising path toward green and sustainable electronics on a global scale in the future. Plastics play a pivotal role in contemporary electronics, including printed circuit boards (PCB), where petroleum‐based polymers such as epoxies form the base insulating substrate. In this review paper, several promising bio‐based alternatives to conventional PCB materials that are recently developed and investigated are stated and discussed regarding their properties, practical utilization, and further perspective. The given list includes polylactic acid (PLA), cellulose acetate (CA), polyvinyl alcohol (PVA), and others, with the development of PLA‐based PCB substrates being the furthest along regarding the use in industry practice. Yet, all of the provided solutions are still only suitable for prototypes or low‐cost electronics without high‐reliability requirements. The reason for this is inferior mechanical and thermal properties of biopolymers compared to traditional petroleum‐based polymers. Further development is therefore essential, including new types of reinforcements and other additives. However, as Life Cycle Assessment analyses discussed in the paper show, biopolymers are capable of significantly reducing the environmental impact and are likely to play a major role in shaping a sustainable path for the electronics industry, which will be a key challenge in the current decade.
Insufficient Mechanical Loading Downregulates Piezo1 in Chondrocytes and Impairs Fracture Healing Through ApoE‐Induced Senescence
Authors: Jia Siming , Liu Weijian , Zhang Mo , Wang Lijun , Ren Chuan , Feng Chen , Zhang Tao , Lv Hongzhi , Hou Zhiyong , Zou Weiguo , Zhang Yingze , Tong Wei , Wang Juan , Chen Wei 
Published: October 2024

AbstractInsufficient mechanical loading impairs fracture healing; however, the underlying mechanisms remain unclear. Increasing evidence indicates that Piezo1 plays an important role in fracture healing, although the effect of Piezo1 on the endochondral ossification of chondrocytes has been overlooked. This study reports that mechanical unloading down‐regulates the expression of Piezo1 in chondrocytes and leads to fracture nonunion. Single‐cell sequencing of calluses revealed that specific deletion of Piezo1 in chondrocytes upregulated the expression of apolipoprotein E (ApoE) in hypertrophic chondrocytes, resulting in delayed cartilage‐to‐bone transition due to enhanced chondrocyte senescence. Based on these results, an injectable and thermosensitive hydrogel is developed, which released an ApoE antagonist in situ at the fracture site. This hydrogel effectively attenuated chondrocyte senescence and, thus, promoted cartilage‐to‐bone transition as well as the fracture healing process. Overall, this data provide a new perspective on the activity of chondrocytes in fracture healing and a new direction for the treatment of fracture nonunion caused by insufficient mechanical loading.
Proteogenomic Landscape of Breast Ductal Carcinoma Reveals Tumor Progression Characteristics and Therapeutic Targets
Authors: Xu Ganfei , Yu Juan , Lyu Jiacheng , Zhan Mengna , Xu Jie , Huang Minjing , Zhao Rui , Li Yan , Zhu Jiajun , Feng Jinwen , Tan Subei , Ran Peng , Su Zhenghua , Liu Xinhua , Zhao Jianyuan , Zhang Hongwei , Xu Chen , Chang Jun , Hou Yingyong , Ding Chen 
Published: October 2024

AbstractMulti‐omics studies of breast ductal carcinoma (BRDC) have advanced the understanding of the disease's biology and accelerated targeted therapies. However, the temporal order of a series of biological events in the progression of BRDC is still poorly understood. A comprehensive proteogenomic analysis of 224 samples from 168 patients with malignant and benign breast diseases is carried out. Proteogenomic analysis reveals the characteristics of linear multi‐step progression of BRDC, such as tumor protein P53 (TP53) mutation‐associated estrogen receptor 1 (ESR1) overexpression is involved in the transition from ductal hyperplasia (DH) to ductal carcinoma in situ (DCIS). 6q21 amplification‐associated nuclear receptor subfamily 3 group C member 1 (NR3C1) overexpression helps DCIS_Pure (pure DCIS, no histologic evidence of invasion) cells avoid immune destruction. The T‐cell lymphoma invasion and metastasis 1, androgen receptor, and aldo‐keto reductase family 1 member C1 (TIAM1‐AR‐AKR1C1) axis promotes cell invasion and migration in DCIS_adjIDC (DCIS regions of invasive cancers). In addition, AKR1C1 is identified as a potential therapeutic target and demonstrated the inhibitory effect of aspirin and dydrogesterone as its inhibitors on tumor cells. The integrative multi‐omics analysis helps to understand the progression of BRDC and provides an opportunity to treat BRDC in different stages.
Glycerol Kinase Drives Hepatic de novo Lipogenesis and Triglyceride Synthesis in Nonalcoholic Fatty Liver by Activating SREBP‐1c Transcription, Upregulating DGAT1/2 Expression, and Promoting Glycerol Metabolism
Authors: Ouyang Shuyu , Zhuo Shu , Yang Mengmei , Zhu Tengfei , Yu Shuting , Li Yu , Ying Hao , Le Yingying 
Published: October 2024

AbstractGlycerol kinase (GK) participates in triglyceride (TG) synthesis by catalyzing glycerol metabolism. Whether GK contributes to nonalcoholic fatty liver (NAFL) is unclear. The expression of hepatic Gk is found to be increased in diet‐induced and genetic mouse models of NAFL and is positively associated with hepatic SREBP‐1c expression and TG levels. Cholesterol and fatty acids stimulate GK expression in hepatocytes. In HFD‐induced NAFL mice, knockdown of hepatic Gk decreases expression of SREBP‐1c and its target lipogenic genes as well as DGAT1/2, increases serum glycerol levels, decreases serum TG levels, and attenuates hepatic TG accumulation. Overexpression of GK in hepatocytes in mice or in culture produces opposite results. Mechanistic studies reveal that GK stimulates SREBP‐1c transcription directly by binding to its gene promoter and indirectly by binding to SREBP‐1c protein, thereby increasing lipogenic gene expression and de novo lipogenesis. Studies with truncated GK and mutant GKs indicate that GK induces SREBP‐1c transcription independently of its enzyme activity. GK contributes to lipid homeostasis under physiological conditions by catalyzing glycerol metabolism rather than by regulating SREBP‐1c transcription. Collectively, these results demonstrate that increased hepatic GK promotes de novo lipogenesis and TG synthesis in NAFL by stimulating SREBP‐1c transcription and DGAT1/2 expression and catalyzing glycerol metabolism.
High‐Energy LiNiO2 Li Metal Batteries Enabled by Hybrid Electrolyte Consisting of Ionic Liquid and Weakly Solvating Fluorinated Ether
Authors: Liu Qian , Xu Jiayi , Jiang Wei , Gim Jihyeon , Tornheim Adam P. , Pathak Rajesh , Zhu Qijia , Zuo Peng , Yang Zhenzhen , Pupek Krzysztof Z. , Lee Eungje , Wang Chongmin , Liu Cong , Croy Jason R. , Xu Kang , Zhang Zhengcheng 
Published: October 2024

AbstractIn pursuit of the highest possible energy density, researchers shift their focus to the ultimate anode material, lithium metal (Li0), and high‐capacity cathode materials with high nickel content (Ni > 80%). The combination of these aggressive electrodes presents unprecedented challenges to the electrolyte. Here, we report a hybrid electrolyte consisting of a highly fluorinated ionic liquid and a weakly solvating fluorinated ether, whose hybridization structure enables the reversible operation of a battery chemistry based on Li0 and LiNiO2 (Ni = 100%), delivering nearly theoretical capacity of the latter (up to 249 mAh g−1) for >300 cycles with retention of 78.6% and in absence of unwanted morphological changes in both electrodes. Extensive characterization assisted by molecular dynamic simulation and density functional theory calculations reveals the function of the fluorinated ether to be far more profound than simple dilution and viscosity reduction. Instead, it induces drastic changes in Li+‐solvation environment, the consequence of which engenders simultaneous stabilization of electrode/electrolyte and interfacing via formation of respective interfacial chemistries. This study further unlocks fundamental knowledge underneath the prevailing “diluent strategy” that is extensively applied by the electrolyte researchers and opens more design space for the next‐generation electrolytes and interphases for these coveted battery chemistries.
Enhanced Coupling Between Soft Ferromagnetism and Displacive Ferroelectricity in the Pb‐Site Modified PbFe1/2Nb1/2O3
Authors: Park Ji‐Hun , Cho Jae‐Hyeon , Lee Nyun Jong , Lee Hyun‐Jae , Lee Ju‐Hyeon , Lee Geon‐Ju , Marlton Frederick P. , Suzuki Motohiro , Hinterstein Manuel , Oh Yoon Seok , Choi Ji‐Won , Hwang Geon‐Tae , Lee Jun Hee , Kim Sanghoon , Kim Kee Hoon , Jo Wook 
Published: October 2024

AbstractAlbeit having great potential toward unprecedented type of applications such as magnetoelectric (ME) sensors and memories, practically useful single‐phase multiferroics that show large coupling between ferromagnetism and ferroelectricity at ambient temperatures are still lacking. Here, the discovery of a new type of perovskite ferroelectrics (Pb,M)(Fe1/2Nb1/2)O3 (M = Fe, Co, Ni) is reported with a magnetically‐active metal ion introduced into a cuboctahedrally‐coordinated Pb position, which exhibits enhanced ME coupling owing to the development of simultaneous soft‐ferromagnetism and lone‐pair ferroelectricity persistent above room temperature. These Pb‐site engineered (Pb,M)(Fe1/2Nb1/2)O3 perovskites exhibit a ME coupling coefficient of ≈40–60 ps m−1, a saturated electric polarization of 14–17 µC cm−2 and a saturation magnetization of 0.15–0.3 µB f.u−1. X‐ray absorption spectroscopy combined with first‐principles calculations demonstrates that the induced ferromagnetism originates from the ferromagnetic superexchange interaction coming from ≈90° bonding between the magnetic ions at the Pb site. The present discovery of the enhanced ME coupling in the Pb‐site engineered perovskite ferroelectrics may provide unforeseen opportunities for applying conventional displacive ferroelectricity in the field of spintronics where ferromagnetism is essentially required.
Application of a Conceptual Stocking Model for Two Recreationally Important Species
Authors: Farrier Sean M. , Koupal Keith D. , Burger Paul R. , Wuellner Melissa R. 
Published: October 2024

ABSTRACTFish stocking continues to be an important and often‐used tool in fisheries management. Mortality of fish may be high in the first few days after stocking due to predation and a lack of appropriate food and habitat. The objective of this study was to develop a conceptual model that may identify stocking locations that can help improve the survival of stocked fish. We identified three factors—predator risk, zooplankton (food) availability and measures of habitat that could be important to the survival of stocked Walleye (Sander vitreus) and White Bass (Morone chrysops) fingerlings in Lake McConaughy, Nebraska. The spatial distribution of these factors was used to create a predictive surface to identify those stocking locations hypothesised to lead to higher survival. Final stocking maps identified the best 12.8% and 13.9% of the predicted area of Lake McConaughy for stocking Walleye and White Bass, respectively. Both maps predicted that the best locations were along the south‐central shoreline of Lake McConaughy. The maps for both species were interestingly similar. These results are likely due to the similarities in predators consuming the stocked species and the zooplankton consumed by fingerlings of both species. Habitat availability may be less important, or other aspects of habitat may need to be considered. Identifying the best locations for stocking based on predation risk and the availability of food and habitat could increase the survival of stocked fishes and help managers reach population objectives.
Path analysis for quality traits and minerals in common bean based on data from multi‐environment experiments
Authors: Ribeiro Nerinéia Dalfollo , de Andrade Fabricio Fuzzer , Maziero Sandra Maria , da Silva Argenta Henrique 
Published: October 2024

AbstractThe number of experiments to be used in path analysis to enhance the efficacy of indirect selection for fast‐cooking common bean (Phaseolus vulgaris L.) lines has not yet been defined. This study sought to break down the correlation coefficient into direct and indirect effects for quality traits and mineral concentration based on data acquired from multi‐environment experiments. Additionally, the study proposed to establish the minimum number of experiments required for path analysis aiming at indirect selection for fast cooking in common bean. Four experiments were conducted in which various quality traits and the concentration of seven minerals were analyzed across 25 common bean cultivars. Variance and path analyses were applied to data from individual experiments and combinations of two, three, and four experiments. Significant cultivar × experiment interaction effects were found for most evaluated traits. The traits exerting the greatest direct effects on cooking time varied across the four experiments. Data from individual experiments were highly variable, resulting in low ability to identify promising traits for indirect selection. However, data from two, three, and four experiments had lower variability and therefore provided a greater ability to identify traits with the greatest direct and indirect effects on cooking time. Mass of 100 grains and calcium concentration emerged as promising traits for indirect selection to achieve fast cooking in common bean. Using data from two experiments allows for an effective interpretation of path analysis results for quality traits and mineral concentration in common bean.
Pore classification method with steady‐state diffusion in complex porous media
Authors: Lee Seunggeon , Kim Dongjae , Nam Jaewook 
Published: October 2024

AbstractIn porous media, the transport and flow through the void phase are influenced by the internal pore network due to its complex morphology. In other words, the contributions of individual pores can vary due to their connectivity within the network and characteristics in physical phenomena. In this study, we propose a pore classification method according to geometries and physical behaviors to understand the role of each pore in microstructure. Our method classifies entire pores into backbone, dead‐end, and isolated pore using connectivity analysis and steady‐state diffusion. The backbone acts as the main pathway for the transportation process. Therefore, backbone fraction can be utilized as a quantitative indicator of the pore network in microstructure. Furthermore, this approach enables us to explore the relationship between classified pores and microstructural properties through numerical experiment using virtual structures. This method can be used for various porous materials, such as battery electrodes, membranes, and soil.
Bimetal anchoring porous MXene nanosheets for driving tandem catalytic high‐efficiency electrochemical nitrate reduction
Authors: Guo Rongyu , Cui Zhijie , Yu Tianyang , Li Jing , Peng Wenchao , Liu Jiapeng 
Published: October 2024

AbstractElectrochemical nitrate reduction reaction (NO3RR) is considered a promising strategy for ammonia synthesis and nitrate removal, in which catalyst development is crucial. Herein, a series of bimetal (Co and Cu) anchoring porous MXene nanosheets (CoxCuy@PM) catalysts were prepared by combining etching and reduction strategy. On the one hand, Cu and Co bimetals provided tandem catalytic active sites for NO3RR. On the other hand, the in‐plane PM exhibited good electrical conductivity and multiple transport pathways. Consequently, the optimized Co7Cu3@PM catalyst achieved a high ammonia yield of 7.43 mg h−1 mg cat.−1 and an excellent Faraday efficiency (FE) of 95.9%. The mechanism of NO3RR was investigated by analyzing electrolysis products and in situ Fourier transform infrared spectroscopy. Furthermore, the Co7Cu3@PM based ZnNO3− battery exhibited the superior power density of 5.59 mW cm−2 and an NH3 FE of 92.3%. This work presents an effective strategy to design MXene‐based high‐performance NO3RR electrocatalysts.
Numerical study on the hydrodynamics of highly viscous liquid under vertical acoustic vibration
Authors: Yu Lei , Jia Yuxin , Zhan Xiaobin , Ma Wenzhe , Jiang Yalong , Shi Tielin 
Published: October 2024

AbstractThis study investigated the hydrodynamics of highly viscous liquid under vertical acoustic vibration, and examined the effects of vibration parameters and filling ratio on the strain rate, stretching index, and convective intensity of high‐viscosity liquid. A numerical simulation model of gas–liquid flows was developed using computational fluid dynamics method and validated through experiment. Under acoustic vibration, the high‐viscosity liquid predominantly experienced extensional and shearing flows. Significant deformation of the high‐viscosity liquid was observed near the interface between gas and liquid. Increasing the amplitude or frequency of acoustic vibration, selecting a combination of low‐frequency and high amplitude under equal acceleration conditions, as well as appropriately reducing the filling ratio can enhance the stretching and shearing effects on the liquid, and improve the strength of convection. The findings also established a predictive relationship between amplitude and frequency, enabling the determination of optimal mixing conditions.
Risk factors and clinical significance of post‐stroke incident ischemic lesions
Authors: Fang Rong , Duering Marco , Bode Felix J. , Stösser Sebastian , Meißner Julius N. , Hermann Peter , Liman Thomas G. , Nolte Christian H. , Kerti Lucia , Ikenberg Benno , Bernkopf Kathleen , Glanz Wenzel , Janowitz Daniel , Wagner Michael , Neumann Katja , Speck Oliver , Düzel Emrah , Gesierich Benno , Dewenter Anna , Spottke Annika , Waegemann Karin , Görtler Michael , Wunderlich Silke , Zerr Inga , Petzold Gabor C. , Endres Matthias , Georgakis Marios K. , Dichgans Martin ,   the DEMDAS investigators
Published: October 2024

AbstractINTRODUCTIONWhile incident ischemic lesions (IILs) are not unusual on follow‐up magnetic resonance imaging (MRI) following stroke, their risk factors and prognostic significance remain unknown.METHODSIn a prospective multicenter study of 503 acute stroke patients, we assessed IILs on registered MRI images at baseline and 6 months, analyzing risk factors and clinical outcomes across 36 months.RESULTSAt 6 months, 78 patients (15.5%) had IILs, mostly diffusion‐weighted imaging‐positive (72%) and clinically covert (91%). Older age and small vessel disease (SVD) lesions were baseline risk factors for IILs. IILs were associated with worse cognitive (beta for global cognition: −0.31, 95% confidence interval [CI]: −0.48 to −0.14) and functional outcomes (beta for modified Rankin scale [mRS]: 0.36, 95% CI: 0.14 to 0.58), and higher recurrent stroke risk (hazard ratio: 3.81, 95% CI: 1.35 to 10.69). IILs partially explained the relationship between SVD and poor cognition.DISCUSSIONIILs are common and are associated with worse cognitive and functional outcomes and stroke recurrence risk. Assessing IILs following stroke might aid prognostication.Highlights
Incident ischemic lesions (IILs) were assessed with registered baseline and 6‐month magnetic resonance imaging (MRI) scans in a stroke cohort.
IILs 6 months after stroke are present in one‐sixth of patients and are mostly clinically silent.
Small vessel disease burden is the main baseline risk factor for IILs.
IILs are associated with cognitive and functional impairment and stroke recurrence.
Assessing IILs by follow‐up MRI aids long‐term prognostication for stroke patients.
Successful transition from intravenous to inhalation anesthesia for respiratory management of coronavirus disease pneumonia: A case report
Authors: Kato Reijiro , Irie Yuhei , Izutani Yoshito , Ishikura Hiroyasu 
Published: October 2024

AbstractBackgroundIn patients with coronavirus disease pneumonia, strong spontaneous breathing increases pulmonary vascular permeability and induces self‐inflicted lung injury, prolonging the intensive care unit stay and worsening prognosis. Therefore, spontaneous respiration must be strictly controlled.Case PresentationA 48‐year‐old man was admitted for respiratory management of severe coronavirus disease pneumonia. Despite immediate ventilatory management, ventilatory failure and air leak syndrome developed, necessitating venovenous extracorporeal membrane oxygenation, intravenous sedation, and muscle relaxation. Over time, the patient's inspiratory effort worsened and the requirement for transvenous anesthesia increased. Therefore, management was switched to inhalation anesthesia after discontinuation of all transvenous anesthetics, maintaining morphine‐only analgesia. Subsequent management enabled effective control of spontaneous respiration, allowing eventual discontinuation of inhalation anesthesia, venovenous extracorporeal membrane oxygenation, and ventilation.ConclusionManagement of spontaneous respiration in coronavirus disease pneumonia can be complicated by resistance to transvenous anesthesia; however, the use of an inhaled anesthetic may present a valuable alternative.
Self‐Adaptive Activation of DNAzyme Nanoassembly for Synergistically Combined Gene Therapy
Authors: Wang Jing , Shang Jinhua , Yu Shanshan , Lin Mengru , Gong Xue , Liu Xiaoqing , Liu Zhihong , Wang Fuan 
Published: October 2024

AbstractDNAzyme represents a promising gene silencing toolbox yet is obstructed by the poor substrate accessibility in specific cells. Herein, a compact DNA nanoassembly, incorporating multimeric therapeutic DNAzyme, was prepared for selective delivery of gene‐silencing DNAzyme with requisite cofactors and auxiliary chemo‐drugs. By virtue of the sequence‐conservative duplex‐specific nuclease, the endogenous miRNA catalyzes the successive and site‐specific cleavage of DNA nanoassembly substrate (nominated as the localized RNA walking machine) and thus ensures the liberation/activation of therapeutic agents with high accuracy and efficacy. The miR‐10b‐stimulated DNAzyme was designed to downregulate the TWIST transcription factor, an upstream promotor of miR‐10b, thus acquiring the self‐sufficient downregulation of TWIST/miR‐10b signaling nodes (self‐adaptive negative feedback loop) for abrogating tumor metastasis and chemo‐resistance issues.