bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microwave Ablation (MWA): Basics, Technique and Results in Primary and Metastatic Liver Neoplasms – Review Article
Authors: Vogl Thomas , Nour-Eldin Nour-Eldin , Hammerstingl Renate , Panahi Bita , Naguib Nagy 
Published: August 2017

Purpose The locoregional interventional oncological treatment approach is an accepted modality for liver neoplasms, especially for hepatocellular carcinoma (HCC) and oligonodular liver metastases.
Materials and Methods The main aim of ablation therapies like microwave ablation (MWA) is to eradicate all malignant cells in a minimally invasive technique under imaging guidance while preserving the healthy tissue with a sufficient safety margin (at least 5 mm) surrounding the ablated lesion.
Results Ablation therapy can be performed via a percutaneous, laparoscopic or intraoperative approach under ultrasound, MRI or CT guidance for adequate localization and monitoring of the ablation process.
Conclusion Ablation is the method of choice for oligonodular HCCs ≤ 3 cm. The technical success rate varies from 88 % to 98 % and progression-free survival (PFS) at 3 years from 27 % to 91.7 %. The same criteria apply to the therapy of liver metastases.
Key Points
Citation Format
Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny
Authors: Silverman Michael , Kua Lindsay , Tanca Alessandro , Pala Mauro , Palomba Antonio , Tanes Ceylan , Bittinger Kyle , Uzzau Sergio , Benoist Christophe , Mathis Diane 
Published: August 2017

Significance
This report brings a new perspective on the decades-old question of how MHC and HLA complexes can potently protect against a variety of autoimmune diseases, including type 1 diabetes. We demonstrated that protection by the MHC-II Eα:Eβ complex operated via modulation of the composition of the intestinal microbiota during a critical early window of ontogeny, associated with modification of the local immune system. These findings prompt a model of HLA/MHC-mediated protection from autoimmunity, and raise the question of whether disease-protective alleles in other human autoimmune diseases or models thereof might operate by a similar mechanism. They also argue that treating infants and pregnant mothers with antibiotics should be minimized.
Isolation, structural identification and biological characterization of two conopeptides from the Conus pennaceus venom
Authors: Abdel-Wahab Mohammed , Miyashita Masahiro , Ota Yoshiyuki , Juichi Hironori , Okabe Ryota , Sarhan Moustafa , Fouda Maged , Abdel-Rahman Mohamed , Saber Samy , Nakagawa Yoshiaki 
Published: August 2017

Abstract
A novel anti-mollusk conopeptide pn4c was isolated from the Conus pennaceus venom by repeated HPLC fractionation based on the activity against freshwater snails. The primary structure of pn4c was determined by the mass spectrometric de novo sequencing analysis. In addition, pn3a was isolated from the same fraction containing pn4c, as a peptide with unknown functions.
Possibilities of altering arm and shoulder muscle activation in a static therapeutic climbing exercise through arm position, hand support and wall inclination
Authors: Pühringer Martin , Strutzenberger Gerda , Leitl Daniela , Holzner Konrad , Schwameder Hermann 
Published: August 2017

AbstractThe aim of the study was to quantify the activation of arm and shoulder muscles during a static therapeutic climbing exercise and to investigate the possibility of altering the muscle activation through arm position (Jug, Undercling, Sidepull internal rotated, Sidepull external rotated), hand support (one‐handed, double‐handed) and wall inclination (0°, 12°). Electromyographic (EMG) activity of 14 healthy, climbing unexperienced males for the right m. biceps brachii (BB), m. serratus anterior (SA), m. upper, middle and lower trapezius (UT, MT, LT) showed mainly low to moderate EMG activation levels (BB: 4.1–40.1% maximum voluntary isometric contraction (MVIC), SA: 4.5–24.5% MVIC, UT: 1.3–28.0% MVIC, MT: 8.6–47.1% MVIC, LT: 3.8–47.3% MVIC). Significant differences occurred between the four arm positions for the UT and LT. The one‐handed support revealed significant higher muscle activation than the double‐handed support in every condition except for SA in Undercling arm position at 12° wall inclination. Increasing the wall inclination (from 0° to 12° overhang) led to a significant increase in muscle activation in nearly every exercise variation and muscle. These findings suggest that arm position, hand support and wall inclination are appropriate possibilities of altering muscle activation patterns in therapeutic climbing.
Assessing ExxonMobil’s climate change communications (1977–2014)
Authors: Supran Geoffrey , Oreskes Naomi 
Published: August 2017

Abstract
This paper assesses whether ExxonMobil Corporation has in the past misled the general public about climate change. We present an empirical document-by-document textual content analysis and comparison of 187 climate change communications from ExxonMobil, including peer-reviewed and non-peer-reviewed publications, internal company documents, and paid, editorial-style advertisements (‘advertorials’) in The New York Times. We examine whether these communications sent consistent messages about the state of climate science and its implications—specifically, we compare their positions on climate change as real, human-caused, serious, and solvable. In all four cases, we find that as documents become more publicly accessible, they increasingly communicate doubt. This discrepancy is most pronounced between advertorials and all other documents. For example, accounting for expressions of reasonable doubt, 83% of peer-reviewed papers and 80% of internal documents acknowledge that climate change is real and human-caused, yet only 12% of advertorials do so, with 81% instead expressing doubt. We conclude that ExxonMobil contributed to advancing climate science—by way of its scientists’ academic publications—but promoted doubt about it in advertorials. Given this discrepancy, we conclude that ExxonMobil misled the public. Our content analysis also examines ExxonMobil’s discussion of the risks of stranded fossil fuel assets. We find the topic discussed and sometimes quantified in 24 documents of various types, but absent from advertorials. Finally, based on the available documents, we outline ExxonMobil’s strategic approach to climate change research and communication, which helps to contextualize our findings.
Multidimensional Neuroanatomical Subtyping of Autism Spectrum Disorder
Authors: Hong Seok-Jun , Valk Sofie L , Di Martino Adriana , Milham Michael P , Bernhardt Boris C 
Published: August 2017

Abstract
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with multiple biological etiologies and highly variable symptoms. Using a novel analytical framework that integrates cortex-wide MRI markers of vertical (i.e., thickness, tissue contrast) and horizontal (i.e., surface area, geodesic distance) cortical organization, we could show that a large multi-centric cohort of individuals with ASD falls into 3 distinctive anatomical subtypes (ASD-I: cortical thickening, increased surface area, tissue blurring; ASD-II: cortical thinning, decreased distance; ASD-III: increased distance). Bootstrap analysis indicated a high consistency of these biotypes across thousands of simulations, while analysis of behavioral phenotypes and resting-state fMRI showed differential symptom load (i.e., Autism Diagnostic Observation Schedule; ADOS) and instrinsic connectivity anomalies in communication and social-cognition networks. Notably, subtyping improved supervised learning approaches predicting ADOS score in single subjects, with significantly increased performance compared to a subtype-blind approach. The existence of different subtypes may reconcile previous results so far not converging on a consistent pattern of anatomical anomalies in autism, and possibly relate the presence of diverging corticogenic and maturational anomalies. The high accuracy for symptom severity prediction indicates benefits of MRI biotyping for personalized diagnostics and may guide the development of targeted therapeutic strategies.
Multiple Chronic Conditions in Spousal Caregivers of Older Adults With Functional Disability: Associations With Caregiving Difficulties and Gains
Authors: Polenick Courtney A , Leggett Amanda N , Webster Noah J , Han Benjamin H , Zarit Steven H , Piette John D 
Published: August 2017

Abstract

Objectives
Multiple chronic conditions (MCCs) are common and have harmful consequences in later life. Along with managing their own health, many aging adults care for an impaired partner. Spousal caregiving may be more stressful when caregivers have MCCs, particularly those involving complex management. Yet, little is known about combinations of conditions that are most consequential for caregiving outcomes.

Method
Using a U.S. sample of 359 spousal caregivers and care recipients from the 2011 National Aging Trends Study and National Study of Caregiving, we examined three categories of MCCs based on similarity of management strategies (concordant only, discordant only, and both concordant and discordant) and their associations with caregiving difficulties and gains. We also considered gender differences.

Results
Relative to caregivers without MCCs, caregivers with discordant MCCs reported fewer gains, whereas caregivers with both concordant and discordant MCCs reported greater emotional and physical difficulties. Wives with discordant MCCs only reported a trend for greater physical difficulties. Caregivers with concordant MCCs did not report more difficulties or gains.

Discussion
Spousal caregivers with MCCs involving discordant management strategies appear to be at risk for adverse care-related outcomes and may benefit from support in maintaining their own health as well as their caregiving responsibilities.
Return migration of adult Atlantic salmon (Salmo salar L.) to northern Norway
Authors: Ulvan Eva Marita , Foldvik Anders , Jensen Arne Johan , Finstad Bengt , Thorstad Eva Bonsak , Rikardsen Audun Håvard , Næsje Tor Fredrik 
Published: August 2017

AbstractThe return migration of adult Atlantic salmon was investigated by analysing recaptures of individuals tagged and released as smolts in the River Altaelva and the River Halselva using a catch per unit effort approach. Although the salmon were recaptured over a large area along the coastline (from &gt;1100 km south to &gt; 500 km northeast of their home rivers), the results indicated a relatively accurate homeward navigation for most individuals. The straying rate to rivers other than the home river was 9%. Multi-sea-winter salmon returned earlier in the season than one-sea-winter salmon, but the geographical distribution of recaptures did not differ. Recaptures were equally distributed north and south of the home rivers, implying that salmon were arriving to the coast both north and south of their home rivers and that they may have returned from different ocean areas. This was supported by the fact that several salmon were recaptured in both the southern and northern parts of the North Atlantic Ocean, including at the Faroes, south coast of Greenland, Svalbard and in the Barents Sea. This study supports the hypothesis that the coastal phase of the natal homing in migrating fish species is neither passive nor guided by currents alone.
Symbolic Powers of Ideals Defining F-pure and Strongly F-regular Rings
Authors: Grifo Eloísa , Huneke Craig 
Published: August 2017

Abstract
Given a radical ideal $I$ in a regular ring $R$, the Containment Problem of symbolic and ordinary powers of $I$ consists of determining when the containment $I^{(a)} \subseteq I^b$ holds. By work of Ein–Lazersfeld–Smith, Hochster–Huneke and Ma–Schwede, there is a uniform answer to this question, but the resulting containments are not necessarily best possible. We show that a conjecture of Harbourne holds when $R/I$ is F-pure, and prove tighter containments in the case when $R/I$ is strongly F-regular.
Antipolitics and the Hindrance of Performance Management in Education
Authors: Snyder Jeffrey W , Saultz Andrew , Jacobsen Rebecca 
Published: August 2017

AbstractPerformance management reforms are a popular way to try to create responsive and improving government. These types of reforms have become commonplace in education policy and the Journal of Public Administration Research and Theory (JPART) has been one of the leading venues for research on these topics. However, under-analyzed are the ways in which performance management policies represent antipolitical bent to education reform. We outline an argument that avoiding political decisionmaking in favor of reforms that create authoritative or purportedly neutral data risks undertaking policy change are not as meaningful as hoped. We select eight articles that represent research on performance management broadly and are thought provoking for a broader consideration of performance management in education policy.
Persistent in vivo cytogenetic effects of radioiodine therapy: a 21-year follow-up study using multicolor FISH
Authors: Livingston Gordon K , Escalona Maria , Foster Alvis , Balajee Adayabalam S 
Published: August 2017

Abstract
Our previous studies demonstrated the cytogenetic effects in the peripheral blood lymphocytes of a 34-year-old male patient who received ablative radioactive 131iodine therapy (RIT) on two different occasions in 1992 and 1994. Assessment of RIT-induced chromosomal damage by the cytokinesis-blocked micronucleus assay (CBMN) showed the persistence of elevated micronucleus frequency in this patient for more than two decades since the first RIT. Subsequent cytogenetic analysis performed in 2012 revealed both stable and unstable aberrations, whose frequencies were higher than the baseline reported in the literature. Here, we report the findings of our recent cytogenetic analysis peformed in 2015 on this patient using the multicolor fluorescence in situ hybridization (mFISH) technique. Our results showed that both reciprocal and non-reciprocal translocations persisted at higher frequencies in the patient than those reported in 2012. Persistence of structural aberrations for more than two decades indicate that these aberrations might have originated from long-lived T-lymphocytes or hematopoietic stem cells. Our study suggests that the long-term persistence of chromosome translocations in circulating lymphocytes can be useful for monitoring the extent of RIT-induced chromosomal instability several years after exposure and for estimating the cumulative absorbed dose after multiple RITs for retrospective biodosimetry purposes. This is perhaps the first and longest follow-up study documenting the persistence of cytogenetic damage for 21 years after internal radiation exposure.
Homo novus/New man
Authors: van der Blom Henriette 
Published: August 2017

The concept homo novus (literally “new man”) and its derivative novitas (“newness” or “the quality of being a new man”) were used by politicians and authors writing about political life in the late Roman republic (c. 133–131 bce). There is no ancient definition of the term, and modern scholars disagree on the precise meaning. However, ancient usage suggests that homo novus was a political term used to describe a politician from outside the senatorial elite in Rome, who was successfully elected to a political magistracy, especially the higher magistracies of praetor and consul. The existence of the term indicates an attempt to maintain exclusivity in the political elite of senatorial families and that this attempt was directed not at the lower classes but mainly at members of the equestrian class, who were their equals in socioeconomic terms. The term was used pejoratively by elite Roman politicians to scorn newcomers competing for the limited number of magistracies; in response some homines novi tried to present their background as advantageous: their lack of politically active ancestors made their own candidacy for office untainted by established networks and corruption. The term and its underlying political and social dynamics is crucial for understanding the rhetoric of the politician and author Marcus Tullius Cicero (106–43 bce) in particular, but also the historical monographs of his near-contemporary Gaius Sallustius Crispus (86–c. 35 bce), and the works of biographers and historians writing about the late republic. Cicero is the largest exponent of the term, but his speeches suggests that other new men dipped into the rhetoric of novitas. Understanding the political and social dynamics behind this concept is also important for any study of late Roman republican politics and the major sociopolitical changes taking place during the civil war and triumviral period (c. 49–31 bce) and the early imperial period (c. 31 bce–100 ce).
Jewish Territorialism (in Relation to Jewish Studies)
Authors: Almagor Laura 
Published: August 2017

The Jewish Territorialist movement was first organized in 1905 when, at the Seventh Zionist Congress, a group of some fifty Zionists left the Zionist movement to form the Jewish Territorialist Organization (ITO). This secession, under the leadership of the famous Anglo-Jewish writer and playwright Israel Zangwill (b. 1864–d. 1926), was a reaction to the Zionist rejection of the British offer of the so-called Guas Ngishu Plateau in Kenya for the establishment of a Jewish settlement, erroneously recorded as the Uganda Proposal. From that moment onward, the Jewish Territorialists searched for areas outside Palestine in which to create settlements of Jews. Zangwill and his collaborators considered numerous locations, most importantly in Mesopotamia, Cyrenaica (Libya), Angola, and Honduras. Moreover, between 1907 and 1914 the ITO functioned as the European partner in Jewish-American philanthropist Jacob Schiff’s Galveston movement, which aimed at diverting Eastern European Jewish immigrants from New York City to the smaller cities in the American Midwest via the Texan port city of Galveston. During the war years (1914–1918), and especially after the issuing of the Balfour Declaration in 1917, Territorialist activity slowed down significantly. Zangwill eventually disbanded the ITO in 1925, but a second “wave” of organized Territorialism followed with the establishment in 1934 of the Freeland League for Jewish Territorial Colonization, eventually under the leadership of the Russian socialist-revolutionary émigré Isaac N. Steinberg (b. 1888–d. 1957) and headquartered in New York City. Until the outbreak of World War II, the Freeland League explored settlement options in French and British Guiana, Madagascar, New Caledonia, the New Hebrides, and Australia. After the war, the Freeland League’s most developed project was targeted at the establishment of an agro-industrial settlement for 30,000 Jews in Dutch Guiana (Suriname). The plan was explicitly “sold” as a partial solution to the European displaced persons problem, and it demonstrates the remarkable shift the Territorialist movement went through from being strictly colonial to voicing explicitly anticolonial ideas. Moreover, the ideological and programmatic differences between the Territorialists and other non-Zionist Jewish groups and movements grew smaller from the 1930s onward. Like several of these groups, the Territorialists became increasingly interested in shifting from the realm of pure politics to also including a more cultural or explicitly Yiddishist set of aims and ambitions. The history of the movement thus helps to shed light both on the story of (non-Zionist) Jewish political behavior during the first half of the twentieth century and on the development of a larger geopolitical narrative connected to peoplehood, population politics, and (post)colonialism.
Survey of period variations of superhumps in SU UMa-type dwarf novae. IX. The ninth year (2016–2017)
Authors: Kato Taichi , Isogai Keisuke , Hambsch Franz-Josef , Vanmunster Tonny , Itoh Hiroshi , Monard Berto , Tordai Tamás , Kimura Mariko , Wakamatsu Yasuyuki , Kiyota Seiichiro , Miller Ian , Starr Peter , Kasai Kiyoshi , Shugarov Sergey Yu. , Chochol Drahomir , Katysheva Natalia , Zaostrojnykh Anna M. , Sekeráš Matej , Kuznyetsova Yuliana G. , Kalinicheva Eugenia S. , Golysheva Polina , Krushevska Viktoriia , Maeda Yutaka , Dubovsky Pavol A. , Kudzej Igor , Pavlenko Elena P. , Antonyuk Kirill A. , Pit Nikolaj V. , Sosnovskij Aleksei A. , Antonyuk Oksana I. , Baklanov Aleksei V. , Pickard Roger D. , Kojiguchi Naoto , Sugiura Yuki , Tei Shihei , Yamamura Kenta , Matsumoto Katsura , Ruiz Javier , Stone Geoff , Cook Lewis M. , de Miguel Enrique , Akazawa Hidehiko , Goff William N. , Morelle Etienne , Kafka Stella , Littlefield Colin , Bolt Greg , Dubois Franky , Brincat Stephen M. , Maehara Hiroyuki , Sakanoi Takeshi , Kagitani Masato , Imada Akira , Voloshina Irina B. , Andreev Maksim V. , Sabo Richard , Richmond Michael , Rodda Tony , Nelson Peter , Nazarov Sergey , Mishevskiy Nikolay , Myers Gordon , Denisenko Denis , Stanek Krzysztof Z. , Shields Joseph V. , Kochanek Christopher S. , Holoien Thomas W.-S. , Shappee Benjamin , Prieto José L. , Itagaki Koh-ichi , Nishiyama Koichi , Kabashima Fujio , Stubbings Rod , Schmeer Patrick , Muyllaert Eddy , Horie Tsuneo , Shears Jeremy , Poyner Gary , Moriyama Masayuki 
Published: August 2017

Abstract
Continuing the project described by Kato et al. (2009, PASJ, 61, S395), we collected times of superhump maxima for 127 SU UMa-type dwarf novae observed mainly during the 2016–2017 season and characterized these objects. We provide updated statistics of the relation between the orbital period and the variation of superhumps, the relation between period variations and the rebrightening type in WZ Sge-type objects. We obtained the period minimum of 0.05290(2) d and confirmed the presence of the period gap above the orbital period ∼0.09 d. We note that four objects (NY Her, 1RXS J161659.5+620014, CRTS J033349.8−282244, and SDSS J153015.04+094946.3) have supercycles shorter than 100 d but show infrequent normal outbursts. We consider that these objects are similar to V503 Cyg, whose normal outbursts are likely suppressed by a disk tilt. These four objects are excellent candidates to search for negative superhumps. DDE 48 appears to be a member of ER UMa-type dwarf novae. We identified a new eclipsing SU UMa-type object, MASTER OT J220559.40−341434.9. We observed 21 WZ Sge-type dwarf novae during this interval and report 18 of them in this paper. Among them, ASASSN-16js is a good candidate for a period bouncer. ASASSN-16ia showed a precursor outburst for the first time in a WZ Sge-type superoutburst. ASASSN-16kg, CRTS J000130.5+050624, and SDSS J113551.09+532246.2 are located in the period gap. We have newly obtained 15 orbital periods, including periods from early superhumps.