bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of <i>Botrytis cinerea</i> on γ-Nonalactone concentration: analysis of New Zealand white wines using SIDA-SPE-GC-MS
Authors: Miller Gillean , Barker David , Pilkington Lisa , Deed Rebecca 
Published: October 2024

Noble rot, caused by infection of grapes with the fungus Botrytis cinerea, is commonly used in the production of dessert-style white wines, imparting desirable aroma descriptors, including dried fruit, honey, and stone fruit. γ-Nonalactone is an aroma compound that is ubiquitous in wine yet has been overlooked in literature for some time. Previously, this compound has been found in higher concentrations in noble rot wines. New Zealand (NZ) is world-renowned for its high-quality white wines, particularly Sauvignon blanc; however, limited research has been carried out on the aroma features of wines produced in lower volumes, such as botrytised dessert styles, and those produced from aromatic grape varieties such as Riesling. Therefore, this work quantified γ-Nonalactone concentrations in 38 NZ commercial white wines, representing botrytised (18) and non-botrytised (20) styles, using SIDA-SPE-GC-MS. These wines were selected to represent a cross-section of NZ white wines, made from Sauvignon blanc, Riesling, and Sauvignon-Sémillon blends, and derived across a range of vintages (2014–2021), and NZ wine regions (Central Otago, Gisborne, Hawke’s Bay, Marlborough, Waiheke Island, Waipara Valley, and Wairarapa). Multivariate data analyses were carried out using vitivinicultural data from wine producers, wine, and measured technical parameters and γ-Nonalactone concentrations. Analyses revealed that γ-Nonalactone concentration was significantly higher in botrytised wines (p-value = 3 × 10-8), with a maximum of 43.5 µg L-1, compared to a maximum of 8.7 µg L-1 in the non-botrytised samples. No significant associations were found between γ-Nonalactone concentration and region or grape variety, suggesting that the precursors to γ-Nonalactone are produced by B. cinerea itself, or through alterations in grape metabolism induced by B. cinerea. Additional research is needed to elucidate the mechanism(s) by which noble rot leads to higher γ-Nonalactone concentrations in wines.
The oxytocin-oxytocin receptors system — a new pathogenetic mechanism in the development of diabetic phenotype of heart failure with preserved ejection fraction in women
Authors: Starchenko A. D. , Liskova Yu. V. , Stadnikov A. A. 
Published: October 2024

Aim. To determine the pathogenetic role of the oxytocinergic system in the development of myocardium structural and functional changes in women with heart failure with preserved ejection fraction (HFpEF) associated with type 2 diabetes mellitus (DM2T) (diabetic phenotype of HFpEF).Material and methods. The study included 60 women aged 67.0±4.9 years with HFpEF stage I-IIA, FC I-III, 30 of them had DM2T who were admitted for elective coronary artery bypass grafting. The development of HFpEF is caused by coronary artery disease (CAD) and arterial hypertension (AH). Prior to surgery, all patients underwent a standard examination, blood levels of NT-proBNP, oxytocin (Ox), echocardiography were determined to find the types of left ventricular (LV) myocardial remodeling and diastolic dysfunction (DD). Myocardium biopsies of the right atrium auricle obtained during coronary bypass surgery were studied by microscopy, morphometry and immunohistochemistry (the expression of oxytocin receptors (OxR), a marker of proliferation ki-67).Results. According to echocardiography, eccentric LV hypertrophy (46.7/36.7%) and DD type 2 (47/17%, p=0.003) prevailed in the group of women with the diabetic phenotype of HFpEF. A higher content of NT-proBNP (480.72±241.87/434.46±282.78 ng/ml, p=0.06) and a lower concentration of Ox (102.11±35.89/320.37±294.71 pg/ml, p=0.0016) in blood serum were established, as well as an increase in the number of cardiomyocytes (CMC) with a high expression level OxR (63.69±19.47/12.16±23.09%, p=0.000) in patients with the diabetic phenotype of HFpEF. Negative associations were determined between the blood level of Ox and the CMC diameter (r=-0.10, p=0.020), the area of their cytoplasm (r=-0.16, p=0.000) and the area of the nuclei (r=-0.11, p=0.015) in patients of both groups. A decrease in Ox concentration in the blood of patients with diabetic phenotype of HFpEF was accompanied by an increase in the number of CMCs with a high level of OxR expression (r=-0.63, p=0.000).Conclusion. The study has shown the important involvement of oxytocinergic signaling pathways in the HFpEF pathogenesis. HFpEF associated with DM2T in women was characterized by more unfavorable structural and functional changes in the myocardium, a significant increase in the number of hypertrophied CMCs with a high level of OxR expression and Ox decrease in blood serum. The mechanisms of the first-established significant increase in the content of Ox in the blood of patients with HFpEF without diabetes and its significant decrease in patients with diabetic phenotype of HFpEF leading to more pronounced structural and functional changes in the myocardium, require further study.
Reconciling tracked atmospheric water flows to close the global freshwater cycle
Authors: De Petrillo Elena , Fahrländer Simon , Tuninetti Marta , Andersen Lauren , Monaco Luca , Ridolfi Luca , Laio Francesco 
Published: October 2024

Abstract

Atmospheric moisture plays a vital role in the hydrological cycle, connecting evaporation sources to precipitationsinks. While high-resolution moisture-tracking models offer valuable insight, discrepancies to atmospheric re-analysis dataemerge. In this study, we reconcile tracked atmospheric water flows with reanalysis data, using the Iterative ProportionalFitting procedure (IPF). We apply IPF to the atmospheric moisture flows from the UTrack dataset (averaged over 2008-2017),aggregated within countries and ocean boundaries. This reconciled dataset ensures that the total tracked atmospheric moisture5equals the total precipitation at the sink and evaporation at the source on an annual basis. Country-scale discrepancies of upto 275% in precipitation and 225% in evaporation are amended, correcting fluxes by∼0.07%, on average. We find 45% ofthe total terrestrial precipitation (∼1.5·105km3yr−1) originates from land evaporation (9.8·104km3yr−1). Our reconciledcountry-scale dataset offers new ground to investigate transboundary atmospheric water flows which connect us globally.
Incidence, risk factors, and outcomes of transplant-associated thrombotic microangiopathy in pediatric patients after allogeneic hematopoietic cell transplantation: A single-institution prospective study
Authors: Koh Kyung-Nam , Yoon Su Hyun , Kang Sung Han , Kim Hyery , Choi Eun Seok , Im Ho Joon 
Published: October 2024

Abstract

Transplant-associated thrombotic microangiopathy (TA-TMA) is an increasingly recognized complication in hematopoietic cell transplantation (HCT). Given the rarity of prospective pediatric studies on TA-TMA, this study aimed to evaluate the incidence, survival outcomes, and risk factors for predicting early the development of TA-TMA in a pediatric population following allogeneic HCT. We conducted a prospective analysis of 173 pediatric patients to evaluate the incidence, survival outcome, and risk factors of TA-TMA. The cumulative incidence of TA-TMA at one-year post-HCT was 3.0% (95% CI, 1.1–6.5%). Patients with TA-TMA showed significantly poorer 1-year overall survival (OS) rate, 50.0% ± 17.7% compared to 85.4% ± 2.8% in those without TA-TMA (p = .008). Additionally, the non-relapse mortality (NRM) rate was higher in the TA-TMA group at 25.0% (95% CI, 3.7–55.8%) versus 5.8% (95% CI, 2.9–10.3%) (p = .038). A urine protein/creatinine ratio ≥ 1 mg/mg on day 30 post-HCT was significantly associated with TA-TMA occurrence (adjusted HR, 9.5; [95% CI], 1.28–70.39; p = .028). This study showed the significantly unfavorable clinical outcomes associated with TA-TMA in pediatric patients and emphasized the importance of early identification of patients at risk. Further research is needed to explore additional strategies for early detection and intervention to improve outcomes.
Patterns of Traditional Chinese Medicine Prescription During Assisted Reproduction in Taiwan: A Population-Based Study
Authors: Shen Yi-Chia , Yang Pei-Rung , Lee I-Yun , Shih Wei-Tai , Yang Yao-Hsu 
Published: October 2024

Abstract

Background
Traditional Chinese medicine (TCM) is widely applied in assisted reproductive technology (ART). However, TCM drug utilization and prescription patterns in assisted reproduction remain unclear. This study was conducted to analyze these patterns.
Methods
Using data from Taiwan’s Artificial Reproductive Database and National Health Insurance Research Database, we analyzed the frequency of TCM prescriptions and the proportions in which different herbal formulae and individual herbs were prescribed to patients undergoing ART procedures. In addition, common TCM prescription patterns were investigated through association rule learning.
Results
In total, 59,266 women undergoing 110,329 ART cycles were enrolled in this study. TCM was used in 27,782 ART cycles (25.18%). Jiawei xiaoyao san and tusizi (Semen cuscutae) were the most commonly used herbal formulae and individual herbs used during ART procedures.
Conclusions
This study demonstrates TCM use patterns in assisted reproduction. Further studies are necessary to evaluate the efficacy and safety of TCMs prescribed during assisted reproduction.
Investigating Waste and Land Use Changes Effects on Air Pollution Using Google Earth Engine in Jakarta Metropolitan in Indonesia
Authors: UMWANZISIWEMUREMYI OSCAR , ABIDIN ZAENAL , SETIAWAN YUDI 
Published: October 2024

Abstract

In recent years, air pollution has intensified due to a continuous rise in atmospheric pollutants. Emissions from anthropogenic activities have exacerbated this problem, contributing to health, environmental, and climate issues. Researchers have identified energy production, industrial processes, wildfires, and volcanic eruption as leading contributors, with waste, changes in land use and land cover (LULC) being secondary factors. Consequently, the growing global waste production and alterations in LULC are among factors in increasing pollution levels, which we seek to emphasise in this research. We specifically investigated the effects of waste and LULC on carbon monoxide (CO), Sulphur dioxide SO2, nitrous dioxide (NO2), and formaldehyde (CH2O) emissions in the Jakarta Metropolitan region, Indonesia. Data were gathered from the Sentinel 2 and Sentinel-5 Precursor satellites and National Waste Management Information System Indonesia (SIPSN) from 2019 to 2023, we employed excel, image analysis, and Google Earth Engine (GEE) for data processing. ArcGIS 10.8 was used for advanced mapping. Our findings revealed that CO, SO2, NO2, and CH2O levels have increased the past five years in correlation with waste and LULC change, with a dip in 2020 during the COVID-19 lockdowns. Efforts to mitigate air pollution include curbing these emissions and promoting green urban planning.
Clinical efficacy of amlodipine and benazepril hydrochloride tablets in controlling morning blood pressure surge (MBPS) in patients with arteriosclerosis
Authors: Zhang Liqin , Ren Fang , Zhao Youying , Ma Hailiang , Shen Jianyao 
Published: October 2024

Abstract

Objective: This prospective, randomized, open-label, parallel-group clinical trial aimed to rigorously evaluate the influence of amlodipine besylate and benazepril hydrochloride tablets on nocturnal blood pressure patterns and morning blood pressure surge in a cohort of patients diagnosed with primary hypertension.
Methods: A total of 294 eligible patients with primary hypertension were randomly assigned to one of two treatment regimens: (1) Bisoprolol amlodipine tablets in the morning (Group A) or (2) Amlodipine besylate and benazepril hydrochloride tablets in the morning(Group B). After 24 weeks of intervention, the following parameters were meticulously compared between the two groups: office blood pressure, morning blood pressure surge, adverse events, 24-hour ambulatory blood pressure monitoring, and major adverse cardiovascular events (MACE). Additionally, the prognostic utility of morning blood pressure surge for predicting future MACE was explored.
Results: A total of 113 and 112 patients in Groups A and B, respectively, successfully completed the 24-week study protocol. Both treatment regimens elicited statistically significant reductions in blood pressure; however, the decrease in diastolic blood pressure was markedly greater in Group B versus Group A (p<0.05). Analysis of the 24-hour ambulatory blood pressure monitoring data revealed an interesting pattern. After 24 weeks, no between-group differences were detected in the variation of daytime ambulatory blood pressure. In contrast, the reductions in nighttime ambulatory systolic and diastolic blood pressure were significantly more pronounced in Group B versus Group A (p<0.05). Furthermore, the morning systolic and diastolic blood pressures were notably higher in Group A versus Group B at the end of the study. Importantly, the magnitude of the morning blood pressure surge was significantly lower in Group B versus Group A (p<0.05). During the subsequent 12-month follow-up period, a total of 42 MACE were observed, with 26 events occurring in Group A and 16 in Group B. Receiver operating characteristic (ROC) curve analysis identified optimal cutoff values for predicting MACE of 27.5 mmHg for morning systolic blood pressure surge (AUC=0.698) and 24.5 mmHg for morning diastolic blood pressure surge (AUC=0.701).
Conclusion: In this population of hypertensive patients, morning blood pressure surge demonstrates moderate prognostic value for future MACE. Importantly, the regimen of administering amlodipine besylate and benazepril hydrochloride tablets in the morning was found to be an effective strategy for improving nocturnal blood pressure, attenuating morning blood pressure surge, and conferring significant long-term cardiovascular benefits.
Prediction of Dementia Onset using the Short-Term Memory Recall Test
Authors: Oshiyama Chiaki , Kobayashi Naoto , Nishimura Takuichi , Niwa Shin-Ichi 
Published: October 2024

Abstract

The increased prevalence of dementia is serious that necessitates simple tests that can identify those at a high risk.
This study aimed to investigate the predictive ability of the Short-Term Memory Recall Test (STMT) for the development of dementia.
A total of 162 patients aged ≥40 years, examined twice at specific intervals ranging from 1 to 7 years, were included in the study. Herein, 96 of 162 patients were being treated for three known risk factors for dementia: hypertension, hyperlipidaemia, and diabetes. Binomial logistic regression analysis combined with receiver operating curve analysis was used to assess the likelihood of developing dementia. A prediction equation was developed using the STMT score and treatment statuses of the three aforementioned diseases as predictor variables. Finally, p-values calculated using the equation and actual prognoses were subjected to discriminant analysis to determine the hit rate, sensitivity and specificity.
Patients with lower STMT scores, older patients, women, and patients undergoing treatment for the three aforementioned diseases were more likely to develop dementia; in 96 patients, the hit rate for prediction was 75.0, with a sensitivity of 81.5 and a specificity of 61.3.
This study demonstrates the reliability of the STMT in predicting the onset of dementia.
Value of the lumbar MRI-based vertebral bone quality score (VBQ) for predicting vertebral fractures
Authors: Chen Ang , Feng Shangyong , She Dunmin , Yan Caifeng 
Published: October 2024

Abstract

Background VBQ is a new method for quantifying bone mass. This study analyzed the influencing factors of vertebral fractures and investigated the value of lumbar MRI-based VBQ for predicting vertebral fractures to provide evidence for clinical intervention.Methods This study included 863 patients who were hospitalized at Northern Jiangsu People’s Hospital from September 2022 to August 2023 and were divided into a vertebral fracture group and a nonvertebral fracture group. The correlations between vertebral fractures and every factor were calculated via the Spearman correlation test; the independent factors of vertebral fracture risk were derived via binary logistic regression analysis; ROC curves were drawn to calculate the independent predictive ability of the VBQ for vertebral fractures, and subgroups were analyzed according to age, sex, and BMI. Differences were considered to represent statistically significant at P < 0.05.Results A total of 863 patients were included in this study, including 489 with vertebral fractures and 374 without vertebral fractures. The serum CTX concentration, serum NTX concentration, and serum vitamin D concentration, minimum T value and VBQ score were independently correlated with vertebral fractures. A prediction model for predicting vertebral fractures was established, and it explained 41.9% of the causes of vertebral fractures. ROC curve analysis revealed that the accuracy of the VBQ score in predicting vertebral fractures was 89.2%, and its cutoff value used to predict vertebral fractures was 2.810, with a sensitivity of 85.9% and a specificity of 78.9%.Conclusion The VBQ score has high value in predicting vertebral fractures. The predictive value of the VBQ score was better in men, those who were younger and who with a greater BMI.
The impact of the COVID-19 pandemic on hospital admissions for psychiatric disorders: results from the multicentre CoMeH study on the Italian population Running title: The impact of COVID-19 on hospital admissions for psychiatric disorders
Authors: Aragona Massimiliano , Ventura Martina , Ciampichini Roberta , Napoli Anteo , Fano Valeria , Leone Sara , Pacifici Martina , Rosini Claudio , Silvestri Caterina , Voller Fabio , Zucchi Alberto , Napoli Christian , Petrelli Alessio 
Published: October 2024

Abstract

Background. To evaluate the impact of the COVID-19 pandemic on hospital admissions for psychiatric disorders, with a focus on the patients’ socioeconomic and demographic characteristics and/or the diagnostic group and type of admission. Methods. Open cohort of individuals aged ≥ 10 years resident for at least two years in one of three large areas of Italy. The outcome was the first admission for a psychiatric disorder (First Mental Health Admission: FMHA) during the study period (January 2018–December 2021). Municipality of residence, sex, census tract deprivation index, citizenship, type of admission and the diagnostic group were considered as covariates of interest. Incidence rate ratios of FMHAs were estimated via an interrupted time series (ITS) analysis using a step-change negative binomial model. Moreover, an ITS analysis was conducted on the monthly number of FMHAs to evaluate the impact of COVID-19 on the temporal trend of FMHAs. Results. Of the 5,159,363 subjects enrolled, 11,171 had an FMHA in the study period. The incidence of FMHAs decreased after the outbreak of the pandemic, overall and by sex, deprivation level and citizenship. Immigrants from high migration pressure countries (HMPCs) had a greater reduction in FMHAs during COVID-19. A decrease in FMHAs was observed for all diagnoses, the only exceptions being for post-traumatic stress and related disorders, which increased. Involuntary admissions also increased dramatically at the outbreak of the pandemic. Younger age (< 34) and high deprivation level were associated with higher risk of hospitalization. In the following post-outbreak period (March 2020-December 2021), a moderate but significant growing trend of FMHAs was observed, although not reaching the pre-pandemic levels. A more robust increase was found especially for patients with eating disorders, while FMHAs for patients with post-traumatic stress and related disorders decreased to the low pre-pandemic levels. Involuntary FMHAs also decreased in the post-outbreak period. Conclusions. The pandemic had a considerable, and in some cases dramatic, impact on hospitalizations for psychiatric disorders. However, the effect appeared temporary, suggesting that the expectations of a dramatic surge in mental health issues due to the pandemic could have been overemphasized, at least in the short term. Longer follow-up surveys are needed.
Efficacy of Continuous intravenous infusion of lidocaine on postoperative sore throat after laryngeal mask insertion: a randomized controlled trial
Authors: Jiang Jianxin , Wu Jimin , Shi Shuqi , Dong Xiaoli , Yin Jiaxiang , Wu Yini 
Published: October 2024

Abstract

Background
This randomized controlled trial was performed to explore efficacy of continuous intravenous infusion of lidocaine on postoperative sore throat after laryngeal mask insertion.
Methods
In this prospective trial one hundred and sixty general anesthesia surgery patients (20 to 60 years) using laryngeal mask airway were randomly divided into control group (Group C, saline as placebo), lidocaine gel group (Group LG, lidocaine gel applied to the surface of the laryngeal mask), single intravenous lidocaine group (Group SL, intravenous lidocaine 1.5 mg/kg at induction of anesthesia) and continuous infusion of lidocaine group (Group CL, a bolus of 1.5 mg/kg, followed by an infusion of 2 mg/kg/h until the end of the surgical). The primary outcomes were the incidence and severity of POST at the time of laryngeal mask removal (T1), 2 h (T2), 6 h (T3), and 24 h (T4) after removal. The secondary outcomes included the incidence of adverse events such as hoarseness, cough, and tongue numbness.
Result
Within 24 hours after extubation, the incidence and severity of POST was significantly lower in group CL than that in group C at all time points. In contrast, compared with group C, the incidence and severity of POST in group SL was lower only at T1. The incidence of hoarseness and cough in group CL were significantly lower than that in group C at T1 and T2. In group SL, the incidence of hoarseness and cough was lower than that in the group C only at T1. In group LG, the incidence of tongue numbness was significantly higher than that in group C only at T1, and there were no significant difference in the four groups at the other time points.
Conclusion
Continuous infusion of lidocaine is effective in reducing the incidence and severity of POST after laryngeal mask ventilation, as well as reducing the incidence of adverse effects such as hoarseness and cough.
Trial Registration:Chinese Clinical Trial Registry(ChiCTR2300070339,04/10/2023).