bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthopedic Manifestations in Patients of Long COVID-19 Syndrome
Authors: Goel Aditya , Qidwai Shakeel A. , Mishra A. N. 
Published: September 2024

Abstract

Background:
It has been widely reported that the new coronavirus has adverse effects on the musculoskeletal system. The primary goal of this study is to establish the frequency of musculoskeletal complaints with extended COVID-19 syndrome.

Methods:
This retrospective cohort research examined the occurrence of musculoskeletal problems in patients with chronic COVID-19 syndrome.

Results:
About 100 COVID-19 patients tested positive, of which 27 (27.0%) had a minimum of one orthopedic impairment. Patients with orthopedic conditions were significantly younger than those without (53.7 years vs. 58.1 years, P = 0.003), and their incidence was significantly higher in obese than nonobese patients (P = 0.022). Furthermore, patients with diabetes had significantly more orthopedic symptoms than those with cardiac or pulmonary complications.

Conclusion:
According to our research, patients who are obese or diabetic have a higher probability of experiencing musculoskeletal symptoms when infected with COVID-19. In addition, analysis is needed to determine whether these orthopedic conditions persist during active disease and postinfection.
Intra-Articular Injection of 0.5% Buprenorphine in Early Osteoarthritis of Knee Joint: A Study of 50 Cases
Authors: Dave Mittal B. , Savajiyani Dixit Nitinkumar , Chauhan Nishant C. , Patel Akash D. 
Published: September 2024

Abstract

Background:
Osteoarthritis (OA) of the knee is a disabling disease. Recently, relatively younger patients with early OA and knee pain are increasing. Intra-articular (IA) therapies need to address the inflammation associated with OA along with pain relief. Recent reports suggest the presence of opioid receptors in peripheral locations and presence of their anti-inflammatory actions of IA opioid injections.

Aim:
To study the role of IA buprenorphine injection in the management of early OA of the knee joint.

Materials and Methods:
A prospective study of 50 patients with early OA was carried out. Patients were administered 2 ml IA 0.5% buprenorphine on days 1 and 7. The results were assessed with Oxford Knee Score (OKS) and Visual Analog Scale (VAS) on days 1, 7, 15, 30, and 90.

Results:
There was a significant improvement in mean OKS till day 30 (P < 0.0001) with values at day 90 showing similar results to day 1. The mean VAS values also showed a significant improvement till day 30 (P < 0.0001). There was no significant change in total neutrophil counts in synovial fluid on day 7. The most common adverse effect reported was nausea and vomiting (24%), pointing to systemic absorption.

Conclusion:
IA injection of buprenorphine showed no reduction in neutrophil counts in synovial fluid in this study and the pain relief resulting may in part be attributable to systemic absorption of the drug. Better depot preparations and further research into chondroprotective action of IA opioid injections are still needed to recommend it as a viable therapeutic option in early OA of the knee.
Platelet-rich Plasma Versus Steroid Injection under C-Arm Guidance in the Management of Sacroiliitis
Authors: Kumar Ashutosh , Kumar Rishabh , Shankar Anand , Kumar Rakesh 
Published: September 2024

Abstract

Objective:
The objective is to evaluate the efficacy of platelet-rich plasma and steroid injection in the management of sacroiliitis.

Background:
Sacroiliitis is considered a diagnostic feature of seronegative spondyloarthropathy (SPA). Sacroiliac joint steroid injection is the most commonly used method. Currently steroid, injection therapy and platelet-rich plasma (PRP) therapy are current treatment trends.

Material and Methods:
This interventional study included 60 patients with seronegative axial SPA. Patients were divided into two groups: group I received a c arm guided steroid injection and group II received a PRP injection. Patients were assessed by Visual Analog Scale and Modified Oswestry Disability Questionnaire (MODQ) at 4 and 8 weeks postinjection and by magnetic resonance imaging (MRI) at 8 weeks postinjection.

Result:
Steroids and PRP are effective in treating sacroiliitis. The improvement was significant and lasted longer in group II (68.6% mild pain by Vas and 74.3% minimal disability related to MODQ) compared to group I at 8 weeks postinjection. Steroid-treated patients improved significantly in 4 weeks (60% of patients experienced mild pain in Vas and 45.7% had minimal defects in MODQ), but efficacy declined after 8 weeks. According to follow-up MRI, active sacroiliitis can be completely improved with PRP injection (57.1% with normal MRI results after 8 weeks).

Conclusion:
Steroids and PRP were effective in the treatment of sacroiliitis in seronegative SPA under C arm guidance. But PRP was persistent and prolonged.
Myopericarditis following COVID-19 vaccination in children: a systematic review and meta-analysis
Authors: Thenpandiyan Ashiley Annushri , Ling Ryan Ruiyang , Grignani Robert , Ling Megan Ruien , Thenpandiyan Arthena Anushka , Tai Bee Choo , Somani Jyoti , Ramanathan Kollengode , Quek Swee Chye 
Published: September 2024

Abstract

Introduction:
Myopericarditis is a rare but serious coronavirus disease 2019 (COVID-19) vaccine-related adverse event primarily affecting adolescents. Given recent approvals for childhood vaccination, we performed a meta-analysis investigating myopericarditis following messenger ribonucleic acid COVID-19 vaccination in children aged <19 years, focusing on its overall risk and high-risk subgroups.

Methods:
We searched MEDLINE via PubMed, Embase and Scopus from inception to 1 August 2022 for observational studies reporting myopericarditis in temporal relation to paediatric COVID-19 vaccination. We conducted random-effects meta-analyses (DerSimonian and Laird) on myopericarditis (primary outcome), myocarditis and pericarditis (secondary outcomes).

Results:
Of 2115 studies, 12 (59,229,160 doses) studies were included in our analysis. There were 19.8 (95% confidence interval [CI]: 10.4–37.6) myopericarditis cases reported per million doses in children, compared to 23.7 (95% CI: 12.2–46.1) cases in adults (eight studies, 376,899,888 doses; P = 0.70). Compared to the second dose (34.4, 95% CI: 15.2–77.8), the number of cases post-first dose was significantly lower (9.1, 95% CI: 4.4–18.8; P = 0.017), while the number of cases post-third dose was not higher than that of post-second dose (28.4, 95% CI: 10.4–61.8; P = 0.57, global P = 0.031). Males were at higher risk of myopericarditis (67.4, 95% CI: 36.5–124.5) than females (6.9, 95% CI: 3.1–15.3; P < 0.0001). Finally, the number of cases was higher (overall P < 0.0001) among children aged ≥12 years (39.9, 95% CI: 24.1–66.0) than among children aged <12 years (3.0, 95% CI: 2.3–3.9).

Conclusion:
Our meta-analysis showed 19.8 cases of myopericarditis per million doses among children, not significantly different from that of adults. Higher risk subgroups included adolescents, males, and those receiving their second dose of vaccination.
Role of cerebrospinal fluid adenosine deaminase measurement in the diagnosis of tuberculous meningitis: an updated systematic review and meta-analysis
Authors: Ngiam Jinghao Nicholas , Koh Matthew Chung Yi , Lye Priscillia , Liong Tze Sian , Ong Lizhen , Tambyah Paul Anantharajah , Somani Jyoti 
Published: September 2024

Abstract

Introduction:
Tuberculous meningitis (TBM) can be difficult to diagnose. Elevated cerebrospinal fluid (CSF) adenosine deaminase (ADA) is often seen in TBM, but its reliability has been questioned. A previous meta-analysis in 2017 had demonstrated the diagnostic utility of CSF ADA in TBM versus non-TBM. We sought to update this meta-analysis with more recent studies, to determine whether CSF ADA could be used to aid in the early recognition of TBM.

Methods:
Electronic searches were performed in PubMed and Scopus on studies published from 2016 to 2022. Ten additional studies were identified and added to 20 studies (from 2000 to 2016) from a previous meta-analysis. Meta-analysis was conducted using the random effects method, estimating the pooled diagnostic odds ratio (DOR) for elevated CSF ADA in the diagnosis of TBM.

Results:
Of the 30 studies included, 16/30 (53.3%) used the Giusti method for measuring ADA. Fourteen (46.7%) studies used an ADA cut-off of 10 IU/L, and 11 (36.7%) studies used an even lower cut-off. The pooled DOR for elevated CSF ADA in the diagnosis of TBM was 45.40 (95% confidence interval [CI] 31.96–64.47, I
2 = 44%). When only studies using the Giusti method were considered, DOR was 44.21 (95% CI 28.37–68.91, I
2 = 40%). Among the studies that used a cut-off of 10 IU/L, DOR was 58.09 (95% CI 33.76–99.94, I
2 = 41%).

Conclusion:
Studies remain heterogeneous but demonstrate that CSF ADA can differentiate TBM from non-TBM. In line with most studies, CSF ADA >10 IU/L supports the diagnosis of TBM in a patient with compatible symptoms and high-risk epidemiology.
An unexpected parasite in bone marrow: Uncommon presentation of a common disease
Authors: Singh Anurag , Rawat Shalini , Verma Anuragani , Kushwaha Rashmi 
Published: September 2024

Abstract
Elephantiasis, also known as filariasis, is a severe public health issue in India. Microfilariae in the bone marrow smears are an unusual and incidental finding. Every peripheral blood and bone marrow aspirate smear must be screened for microfilariae in endemic areas to identify asymptomatic carriers. Here, we report a case of a 50-year-old man who presented with pyrexia of unknown origin. He had mild pallor and right-side inguinal lymphadenopathy. Peripheral blood showed anemia and leukocytosis with neutrophilia. Other serological tests, radiological examination, and aspiration cytology from the lymph node were inconclusive. The bone marrow aspirate smears incidentally displayed microfilaria, and the inguinal lymph node demonstrated an adult filaria worm. The association of microfilaria infection with pyrexia of unknown origin (PUO) and peripheral blood neutrophilia has been rarely reported in the literature. The patient recovered from fever and weakness with antifilarial medication and hematinics.
Employing patient-centric health education for the prevention of parasitic infections
Authors: Khanna Vinay , Khanna Ruchee , Chandrashekar U. K. , Ashok Lena 
Published: September 2024

Abstract

Background:
Soil-transmitted infections such as Ascaris lumbricoides, Hookworm, Trichuris trichiura, and Strongyloides stercoralis are common in South India. Factors such as diet, sanitation, and living conditions play a role in the prevalence of helminthic diseases. Many individuals remain asymptomatic carriers. Timely intervention is essential to prevent these infections.

Materials and Methods:
This is a prospective, randomized intervention study that enrolled 52 participants, excluding children, all of whom had parasitic infections. A prevalidated questionnaire was given to assess the risk factors for parasitic diseases, and fecal examinations were conducted to identify parasitic infestations. The World Health Organization’s hand hygiene self-assessment framework was used to evaluate handwashing skills. Subsequent posttesting and resampling of patients allowed for score comparison, assessment of reductions in parasitic load, determination of cure rates, and monitoring of patient readmission rates.

Results:
After the health education intervention, a statistically significant improvement (P < 0.01) was observed in patients’ knowledge and attitudes toward parasitic infections, as shown by their posttest scores compared to their pretest scores. In addition, there were notable improvements in handwashing skills following the implementation of the handwashing educational program.

Conclusion:
This research confirms that health education is vital in promoting proper hand hygiene, reducing parasitic infections, and urging timely medical care for these conditions.
Free-living amoebic encephalitis – Case series
Authors: Puthanpurayil Sithara Nasar Thottathil , Mukundan Aiswarya , Nair Suryakala Ravi , John Anu Pudurkara , Thampi Mithuna Rohini , John Reena , Sehgal Rakesh 
Published: September 2024

Abstract

Introduction:
Free-living amoeba is ubiquitous in fresh water, mud, and moist soil; although seldom pathogenic to humans, Naegleria fowleri, Acanthamoeba spp., and Balamuthia spp. are known to cause infections of the central nervous system.

Methods:
We report two interesting cases, both of which presented with a rapid-onset and fulminant course. The first case details a 36-year-old male with a history of surgically corrected nasal bone fracture 15 years back, who presented with acute onset of fever, headache and convulsions.

Results:
Direct smears of cerebrospinal fluid (CSF) revealed motile trophozoites resembling N. fowleri and were later confirmed by molecular diagnosis (polymerase chain reaction [PCR]). Subsequently, the source was identified as water used for religious purposes. Unfortunately, the patient succumbed to cardiac arrest. The second case is that of a 4-year-old boy from Palakkad district, Kerala, who presented with sudden onset of nasal discharge, fever, headache, vomiting, seizures and altered sensorium. His CSF smear examination showed motile trophozoites resembling Acanthamoeba spp. While undergoing treatment, he seized thrice before going into cardiac arrest. Despite extensive resuscitation measures, the child could not be revived and passed away. The postmortem CSF sample sent for molecular analysis confirmed infection by Acanthamoeba spp.

Conclusion:
Rapid progression and lack of definite treatment options make this a highly fatal condition. Although clinical presentations of both patients were indicative of pyogenic meningitis, parasitic infection was suspected when the CSF was found turbid with no bacteria, high protein, and low sugar. High index of suspicion helped us to get an early preliminary diagnosis from direct microscopy.
Isolated cysticercosis of the liver – A rare case report on diagnosis and management of an incidental finding during prepyloric perforation peritonitis repair
Authors: Babu Basil , Jayant Divij , Behera Arunanshu , Tandup Cherring , Thakur Vipul , Kothari Anand , Nada Ritambra 
Published: September 2024

Abstract
Cysticercosis is one of the most common parasitic infections seen in the human population which most commonly affects the nervous system. Isolated cysticercosis of the liver is rare, and only less than five cases have been reported in the literature. Here, we describe an isolated cysticercosis of the liver. The cyst appeared as a firm nodule on the surface of the liver during a prepyloric perforation repair. The biopsy of the nodule revealed a cyst wall, and a contrast-enhanced computed tomography postoperative showed cysts in the liver. The patient was further evaluated with whole-body imaging which did not reveal any other cysts elsewhere.
Dirofilariasis in the hiding in oral cavity of a patient from Karnataka, India
Authors: Veetil Sreelatha Shankaran , Ashraf Asem Ali , Koshy Jerlin , Karnaker Vimal Kumar 
Published: September 2024

Abstract
“Human dirofilariasis, caused by filarial worms of the genus Dirofilaria, is considered an emerging zoonotic filarial infection transmitted to humans by zoo-anthropophilic blood-sucking insects. The most common Dirofilaria species causing human infections include Dirofilaria repens and Dirofilaria immitis. In this case report, we present the case of a 60-year-old male patient who reported the presence of an intraoral swelling in the right maxillary vestibular region. Upon excision of the lesion and further microscopic and histological examination, a female Dirofilaria was identified as the causative agent.”
Prevalence of intestinal parasitic infections among the pregnant women in South and South East Asian countries: A systematic review and meta-analysis
Authors: Garg Shubha , Garg Ankur , Ravishankar N. , Garg Vinay 
Published: September 2024

Abstract
Intestinal parasitic infections (IPIs) are a major health concern in resource-limited countries of South/South-East Asian region. Despite posing a potential threat to maternal and fetal health, there is limited data available on the actual burden of IPI among pregnant women. Through this systemic review and meta-analysis, we sought to determine the pooled prevalence of IPI and species-specific prevalence among pregnant women in this region. Subgroup analysis was done by region, stool examination technique, and study settings. Among 220 retrieved studies, 21 studies from 8 countries across the region were found eligible and included in this study. The estimated overall pooled prevalence of IPIs among pregnant women was 43.15% (95% confidence interval: 30.66–56.10). The most prevalent IPI was Ascaris lumbricoides (25.14%) and predominant protozoa was Entamoeba histolytica/dispar (6.96%). In subgroup analysis, the estimated pooled prevalence of IPIs in Nepal, India, Thailand, and Thai–Burmese Border was 40.88%, 28.33%, 55.38%, and 23.78%, respectively. Studies using Kato-Katz technique for stool examination showed the highest estimated pooled IPI prevalence (62.70%). The prevalence of IPI was found to be lower in facility-based studies (38.12%) than that of studies done in the community (66.21%). Considering the high burden of IPI in pregnant women as estimated in our review and the already established impact of IPI infection on maternal health and fetal outcomes, we recommend implementation of the preventive chemotherapy during routine antenatal checkups.
Correlates Of Mental Health Among Adolescents In Ikom Local Government Area, Cross River State, Nigeria: Counseling Implications
Authors: Maria Enemeba Ngwu , Jude Uzodinma Ofoegbu , Affiong Sunday Okoh 
Published: September 2024

The study investigated the correlates of mental health among adolescents in Ikom Local Government Area of Cross River State, Nigeria. Two research questions and two research hypotheses were formulated to guide the study. The study adopted the descriptive survey research design; stratified random sampling was used to select the sample for the study. The population of the study consists of adolescents in Ikom Local Government Area numbering Five Hundred Thousand (500,000). The sample of 500 adolescent was collected from ten (10) secondary schools in Ikom Local Government Area of Cross River State. The questionnaire titled Correlates of Mental Health Among Adolescent Questionnaire (COMHAQ) was used for the study. The accruing data was analyzed using Pearson Product Moment Correlation Statistics. The result of the study indicated a positive relationship between substance abuse, social media on mental health of the adolescents. Based on the result of the study, it was recommended among others that drug education and its effect be included in school curriculum. Rehabilitation counseling and centres to help victims should be established, counselors should encourage and train social media addict on effective usage motivational enhancement therapy. This will make the adolescent adopt effective social media usage.
ANALYZE ON THE CULTURE OF ENTREPREURSHIP OF ARAPGIR DEVELOPMENT MODEL
Authors: TALAS Mustafa 
Published: September 2024

Developlment is a versatilen issue with its economic, social and cultural dimensions. These have social, economical and cultural character. Because of the fact that social sturctures are output of human and environment, we wanted to research Arapgir People and their environmental factours. Arapgir has got a lot of elite people espically poltics, artistic, adminstartive manpower. In this context Arapgir has a big performance according to its neighbor town. In this study Evaluation of Arapgir Agrarian Development Model has analyzed on account of enterpreneurship cultural developed Arapgir Municipality. This development model is very important key role for Arapgir due to the fact that it has made difference regional porgress in Arapgir city. This project has been aimed compound environs town about development. In this context, this study has been researched with scouring model. Sociological theory has been taken over metodologically. Books, manuscripts, and data on web media have drewn on as material documents. In addition to it has done interview about Arapgir with worthies and noted a lot of issues. These are very significant for research. Firstly we studied conceptual framework in this article. Secondly we have introduced Arapgir City as her futures. Finaly we explained that Arapgir Agrarian Devolopment Model.	KeyWords: Arapgir, enterpreneurship, enterpreneurship culture, development, agrarian development.
Thermal Management and Optimization Study of Immersion Cooled Battery Pack Using Different Dielectric Fluids
Authors: Basavaraja Meti  , Derisala Ramakrishna  , Dr. Sajith V  , Dr. Ashok S  
Published: September 2024

Electric vehicles with green power system are viable alternatives to reduce greenhouse gas emissions and dependence on fossil energy resources. The power source such as Li-ion battery has high sensitivity to temperature, which is a challenge related to battery thermal management. Effective thermal management is crucial for enhancing the performance and lifespan of electric vehicle (EV) batteries. Developing a BTM system that is both safe and reliable has a vital research goal. Immersion cooling, which submerges the battery in a dielectric fluid, has the potential of increasing the rate of heat transfer by 10,000 times relative to passive air cooling. In the present work, immersion cooling technique with dielectric fluid for 39 cells (4.6Ah), form factor of 21700 battery pack (660Wh) for 2C, 3C and 5C discharge rate with 2LPM, 4LPM and 6LPM have been introduced. From CFD simulations study it’s observed that Maximum cell avg. temperature [97.50 ℃] can be observed at 2lpm_5C condition in 3M Novec dielectric fluid battery pack. Minimum cell avg. temperature [29.93] can be observed at 6lpm_2C condition in Ester mivolt dielectric fluid battery pack. The cell average temperature is 2.56%, 4.11% and 12.02 % lesser for Ester Mivolt DF7 than 3M NOVEC dielectric fluid at 2C, 3C and 5C discharge rate conditions respectively. Observing the results, its recommended to use Ester mivolt coolant instead of 3M Novec, for better thermal management. To examine the real battery module cells with bus bars and holders are taken into consideration, volumetric heat source for different discharge rate is calculated and given heat value. This work presents direct liquid contact cooling using dielectric fluids as a secure and effective thermal management technique for lithium-ion battery applications requiring high energy density and high current.
Problems of economic policy in federal districts
Authors: Васильев О.С. 
Published: September 2024

В статье рассматриваются тенденции развития способов оценки экономического развития в федеральных округах Российской Федерации. Показано, что для совершенствования регулирования требуется разработать и внедрить унифицированную систему оценки показателей эффективности регионов для стабилизации ситуации. Обосновывается необходимость разработки системы мотивации, позволяющей проблемным регионам улучшить ситуации, с целью повышения качества жизни населения.
The article examines trends in the development of methods for assessing economic development in the federal districts of the Russian Federation. It is shown that in order to improve regulation, it is necessary to develop and implement a unified system for assessing regional performance indicators to stabilize the situation. The author also substantiates the need to develop a motivation system that allows problem regions to improve situations in order to improve the quality of life of the population.