bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor Microenvironment: From Cervical Carcinogenesis to Therapeutic Advancements
Authors: Sharma Srishti , Verma Meenakshi , Rautela Indra , Khan Fahad , Pandey Pratibha 
Published: September 2024

Abstract:
Cervical cancer has become a major worldwide health concern that demands attention
to women's health and often needs more effective and specialized treatment options. Cervical
cancer claims the lives of over 300,000 women globally, ranking as the fourth most prevalent
cancer among women. The tumor microenvironment (TME) shapes a distinctive landscape for
tumor survival, characterized by factors like immunosuppression, hypoxia, acidity, and nutrient
scarcity. Comprising tumor cells, immune cells, mesenchymal cells, cancer-associated fibroblasts,
and extracellular matrix, the TME reprograms key aspects of tumor development, uncontrolled
proliferation, invasion, metastasis, and response to treatments. Recognizing the TME's
pivotal role in tumor progression and treatment responsiveness, targeting the TME has emerged
as a potential strategy in cancer therapy. This publication delves into recent TME research, offering
a comprehensive overview of the specific functions of each TME component in cancer
development and progression. Based on the reviewed literature, it appears that women with cervical
cancer may benefit from more effective therapy, fewer side effects, and a higher quality of
life in the future. By addressing pressing problems and unmet needs in the field, this review has
the potential to significantly alter the course of cervical cancer treatment in the future. Furthermore,
it outlines the primary therapeutic targets identified by researchers, which may prove valuable
in treating tumors.
Techno-feasibility assessment on utilization of rice husk and wood scrap as energy sources of the rotary drier while drying BSF maggot
Authors: Purwaka Purwaka , Susastriawan Anak Agung Putu , Saputra Hadi , Rahayu Suparni Setyowati , Hidayat Taufiq , Sidharta Bambang Wahyu , Mathur Akanksha 
Published: September 2024

Black Soldier Flies (BSF) maggot business got increasing attention nowadays, especially dried BSF maggot. The dried BSF maggot is very suitable for fish feed, thus dried maggot business has good prospectus not only in terms of financial sector but also in terms of waste management sector. Unfortunately, making dried maggot requires high cost during drying process, since additional cost for LPG is needed. It is important to replace LPG fuel by less expensive one, such as biomass fuel. Indonesia has huge potential of biomass energy sources which mainly come from agricultural, forestry, and industrial waste. The present work aims to investigate techno-feasibility of rice husk and waste scrap waste as feedstock of rotary drum drier. The experimental work is conducted by drying 10 kg fresh BSF maggot for 2 hours in the drier using blend feedstock of 6 kg rice husk- 6 kg wood scrap (RH-WS) and feedstock of 12 kg wood scrap (WS). The results depict that the waste of rice husk and wood scrap are technological feasible as energy sources for rotary drum dryer while drying BSF maggot. The performance of the drier in terms of drying rate, drying heat, specific fuel consumption, and drier’s effectiveness is better when a blend of rice husk and wood scrap is used as a feedstock. The values of drying rate, drying heat, specific fuel consumption, and drier’s effectiveness when using blend feedstock are 0.92 g/s, 20996.37 kJ, 27940.15 kJ/kg, and 0.67, respectively. It is recommended to use waste of rice husk and wood scarp in blending form to obtain optimum performance of the rotary drier while drying BSF maggot.
The Added Value of Using Video in Out-of-Hours Primary Care Telephone Triage Among General Practitioners: Cross-Sectional Survey Study
Authors: Nebsbjerg Mette Amalie , Bomholt Katrine Bjørnshave , Vestergaard Claus Høstrup , Christensen Morten Bondo , Huibers Linda 
Published: September 2024

Abstract

Background
Many countries have introduced video consultations in primary care both inside and outside of office hours. Despite some relational and technical limitations, general practitioners (GPs) have reported the benefits of video use in the daytime as it provides faster and more flexible access to health care. Studies have indicated that video may be specifically valuable in out-of-hours primary care (OOH-PC), but additional information on the added value of video use is needed.

Objective
This study aimed to investigate triage GPs’ perspectives on video use in GP-led telephone triage in OOH-PC by exploring their reasons for choosing video use and its effect on triage outcome, the decision-making process, communication, and invested time.

Methods
We conducted a cross-sectional questionnaire study among GPs performing telephone triage in the OOH-PC service in the Central Denmark Region from September 5, 2022, until December 21, 2022. The questionnaire was integrated into the electronic patient registration system as a pop-up window appearing after every third video contact. This setup automatically linked background data on the contact, patient, and GP to the questionnaire data. We used descriptive analyses to describe reasons for and effects of video use and GP evaluation, stratified by patient age.

Results
A total of 2456 questionnaires were completed. The most frequent reasons for video use were to assess the severity (n=1951, 79.4%), to increase the probability of self-care (n=1279, 52.1%), and to achieve greater certainty in decision-making (n=810, 33%) (multiple answers were possible for reasons of video use). In 61.9% (n=1516) of contacts, the triage GPs anticipated that the contact would have resulted in a different triage outcome if video had not been used. Use of video resulted in a downgrading of severity level in 88.3% (n=1338) of cases. Triage GPs evaluated the use of video as positive in terms of their decision-making process (n=2358, 96%), communication (n=2214, 90.1%), and invested time (n=2391, 97.3%).

Conclusions
Triage GPs assessed that the use of video in telephone triage did affect their triage outcome, mostly by downgrading the level of care needed. The participating triage GPs found video in OOH-PC to be of added value, particularly in communication and the decision-making process.
Social Media Recruitment as a Potential Trigger for Vulnerability: Multistakeholder Interview Study
Authors: Matthes Nina , Willem Theresa , Buyx Alena , Zimmermann Bettina M 
Published: September 2024

Abstract

Background
More clinical studies use social media to increase recruitment accrual. However, empirical analyses focusing on the ethical aspects pertinent when targeting patients with vulnerable characteristics are lacking.

Objective
This study aims to explore expert and patient perspectives on vulnerability in the context of social media recruitment and seeks to explore how social media can reduce or amplify vulnerabilities.

Methods
As part of an international consortium that tests a therapeutic vaccine against hepatitis B (TherVacB), we conducted 30 qualitative interviews with multidisciplinary experts in social media recruitment (from the fields of clinical research, public relations, psychology, ethics, philosophy, law, and social sciences) about the ethical, legal, and social challenges of social media recruitment. We triangulated the expert assessments with the perceptions of 6 patients with hepatitis B regarding social media usage and attitudes relative to their diagnosis.

Results
Experts perceived social media recruitment as beneficial for reaching hard-to-reach populations and preserving patient privacy. Features that may aggravate existing vulnerabilities are the acontextual point of contact, potential breaches of user privacy, biased algorithms disproportionately affecting disadvantaged groups, and technological barriers such as insufficient digital literacy skills and restricted access to relevant technology. We also report several practical recommendations from experts to navigate these triggering effects of social media recruitment, including transparent communication, addressing algorithm bias, privacy education, and multichannel recruitment.

Conclusions
Using social media for clinical study recruitment can mitigate and aggravate potential study participants’ vulnerabilities. Researchers should anticipate and address the outlined triggering effects within this study’s design and proactively define strategies to overcome them. We suggest practical recommendations to achieve this.
Implementation and User Satisfaction of a Comprehensive Telemedicine Approach for SARS-CoV-2 Self-Sampling: Monocentric, Prospective, Interventional, Open-Label, Controlled, Two-Arm Feasibility Study
Authors: Voit Florian , Erber Johanna , Egert-Schwender Silvia , Hanselmann Michael , Laxy Michael , Kehl Victoria , Hoffmann Dieter , Jeske Samuel D , Michler Thomas , Protzer Ulrike , Kohlmayer Florian , Schmid Roland M , Spinner Christoph D , Weidlich Simon 
Published: September 2024

Abstract

Background
The universal availability of smartphones has created new opportunities for innovative telemedicine applications in health care. The COVID-19 pandemic has heightened the demand for contactless health care services, making SARS-CoV-2 polymerase chain reaction (PCR) testing a crucial component of pandemic containment.

Objective
This feasibility study aimed to examine a comprehensive telemedicine approach for SARS-CoV-2 testing, focusing on the practicality, user satisfaction, and economic implications of self-sampling guided by a telemedicine platform.

Methods
The study process involved shipping self-sampling kits, providing instructions for at-home sample collection, processing biomaterials (swabs and capillary blood), communicating test results, and providing interoperable data for clinical routine and research through a medical mobile app. A total of 100 individuals were randomly assigned to either the conventional health care professional (HCP)–performed SARS-CoV-2 testing group (conventional testing group, CG) or the telemedicine-guided SARS-CoV-2 self-sampling approach (telemedicine group, TG). Feasibility of the TG approach, user satisfaction, user-centered outcomes, and economic aspects were assessed and compared between the groups.

Results
In the TG group, 47 out of 49 (95%) individuals received a self-sampling kit via mail (76%) individuals successfully returned at least one sample for diagnostics. SARS-CoV-2 PCR tests were conducted in 95% () of TG cases compared with 88% () in the CG. Users in the TG reported high satisfaction levels with ease of use (5.2/7), interface satisfaction (5.2/7), and usefulness (4.3/7). A microcosting model indicated a slightly higher cost for the TG approach than the CG approach. The TG demonstrated the potential to facilitate interoperable data transmission by providing anonymized, standardized datasets for extraction using Health Level 7-Fast Healthcare Interoperability Resources. This supports the national COVID-19 Data Exchange Platform and facilitates epidemiological evaluation based on the German COVID Consensus dataset.

Conclusion
These preliminary findings suggest that a telemedicine-based approach to SARS-CoV-2 testing is feasible and could be integrated into existing hospital data infrastructures. This model has the potential for broader application in medical care, offering a scalable solution that could improve user satisfaction and treatment quality in the future.
Practical Applications of Large Language Models for Health Care Professionals and Scientists
Authors: Reis Florian , Lenz Christian , Gossen Manfred , Volk Hans-Dieter , Drzeniek Norman Michael 
Published: September 2024

Abstract
With the popularization of large language models (LLMs), strategies for their effective and safe usage in health care and research have become increasingly pertinent. Despite the growing interest and eagerness among health care professionals and scientists to exploit the potential of LLMs, initial attempts may yield suboptimal results due to a lack of user experience, thus complicating the integration of artificial intelligence (AI) tools into workplace routine. Focusing on scientists and health care professionals with limited LLM experience, this viewpoint article highlights and discusses 6 easy-to-implement use cases of practical relevance. These encompass customizing translations, refining text and extracting information, generating comprehensive overviews and specialized insights, compiling ideas into cohesive narratives, crafting personalized educational materials, and facilitating intellectual sparring. Additionally, we discuss general prompting strategies and precautions for the implementation of AI tools in biomedicine. Despite various hurdles and challenges, the integration of LLMs into daily routines of physicians and researchers promises heightened workplace productivity and efficiency.
Control of the reference posture of a mobile robot with differential type wheels using the intermediate point technique
Authors: Gómez Ó. , Figueroa J. , Montaño M. , Rovira R. 
Published: September 2024

This manuscript aims to implement and evaluate a control approach known as a midpoint to guide a wheeled mobile robot toward a reference position and orientation. Instead of prescribing a specific path, the robot can choose any feasible way to reach the goal.
The method used uses a control algorithm based on the intermediate point. Initially, a controller based on the orientation error and the distance to the target is used to guide the robot towards the desired reference point. The angular velocity is controlled as a function of the orientation error . In contrast, the translational velocity is adjusted in proportion to the distance to the reference point. The kinematic model of the mobile robot with differential-type wheels is used to validate the algorithm.
The control algorithm based on the midpoint technique is verified using a kinematic model of a wheeled mobile robot. A reference posture and an initial posture of the robot are established. The generated trajectory is verified in simulation using the Matlab software and physically using the mobile robot “mbot neo” from the Makeblock company. After several tests, the results show that the robot has reached the specified reference position with the required orientation.
Pengaruh Nyeri Kronik dalam Penurunan Fungsi kognitif
Authors: Fahreza Arraisyi  , Imran Yudhisman 
Published: September 2024

Nyeri merupakan gejala yang sering dikeluhkan masyarakat, Di Indonesia sendiri nyeri kronik adalah alasan paling umum pasien untuk berkunjung ke klinik rawat jalan. Nyeri kronik merujuk pada nyeri yang berkelanjutan lebih dari tiga bulan. Penyebab nyeri kronik tersering adalah nyeri punggung bawah kronik, diikuti oleh nyeri leher kronik, migrain, osteoartritis, gangguan muskuloskeletal lainnya, nyeri kepala akibat penggunaan obat yang berlebihan, dan polineuropati diabetikum
Prevalensi nyeri kronik meningkat seiring dengan bertambahnya usia. Nyeri kronik merupakan masalah kesehatan di seluruh dunia, mempengaruhi 19% orang dewasa Eropa dan 20,4% di Amerika Serikat.
Keluhan subjektif pasien nyeri kronik dari berbagai penelitian menunjukkan bahwa nyeri kronik dikaitkan dengan defisit kognitif. Pada pasien nyeri kronik terjadi interaksi antara nyeri dan fungsi kognitif secara lebih kompleks. Hal ini menyebabkan gangguan fungsi otak yang berkembang mengikuti progresi dari nyeri kronik. Pada nyeri kronik dijumpai aktifitas neuron yang berlebihan, disfungsi jaringan dan pengurangan volume grey matter. Kehilangan grey matter dijumpai dalam amigdala, korteks entorinal girus hipokampus, girus singulata anterior, thalamus dan insula.
Hubungan antara nyeri kronik dan penurunan fungsi kognitif selayaknya diperhatikan lebih lanjut dikarenakan memiliki implikasi terhadap fungsi dan kualitas hidup individu. Berbagai penelitian menunjukkan hasil hubungan signifikan terbalik penurunan dari atensi, memori, proses informasi dan fungsi eksekutif pada pasien dengan nyeri kronik.
Acessibilidade Cultural de Base Comunitária
Authors: Dorneles Patricia Silva , Carvalho Claudia Reinoso Araujo de 
Published: September 2024

Embora o direito à cultura esteja presente na nossa constituição formulada em 1988, observa-se que nos últimos quinze anos a pauta da cidadania cultural das pessoas com deficiência têm desafiado as políticas públicas de cultura à efetivação desse direito, de forma emancipatória e anticapacitista. Com o processo de democratização do país, gestões públicas progressistas do campo da esquerda brasileira, no início dos anos 90, avançaram também nos processos de democratização cultural. Como resultado, verifica-se ao longo do tempo, ainda que com período de retrocesso na pauta, a emergência das políticas culturais de base comunitária, de cidadania e de diversidade cultural. Este artigo tem como objetivo refletir sobre o contexto da pauta da acessibilidade cultural para pessoas com deficiência. Discute-se aqui iniciativas para qualificar a agenda de direito cultural desta população, bem como estratégias para comprometer os diferentes agentes do campo da cultura com a qualificação do capital cultural das pessoas com deficiência. Destaca-se a parceria entre a Universidade Federal do Rio de Janeiro - UFRJ e o Ministério da Cultura – MINC, entre 2013 e 2019, a partir das vagas ofertadas aos Pontos de Cultura no Curso de Especialização em Acessibilidade Cultural - CEAC e outras ações na atuação de sensibilização destas iniciativas de base comunitária na agenda da cidadania cultural das pessoas com deficiência. O processo histórico de exclusão, invisibilidade e o preconceito ainda são barreiras a serem enfrentadas. Verifica-se ainda que a condição sociocultural da população com deficiência no Brasil e no mundo se apresenta como pauta significativa, tendo em vista o objetivo de promover o desenvolvimento sustentável. Concluiu-se que as iniciativas culturais de base comunitária são fundamentais para a promoção da cidadania cultural de pessoas com deficiência e em vulnerabilidade social. Desta forma, destaca-se a importância do Programa Cultura Viva e seu forte compromisso com os desafios sociais previstos na Agenda 2030, que implica na atualização da pauta da cidadania cultural das pessoas com deficiência numa perspectiva anticapacitista.
Peran Perceived Social Support terhadap Academic Anxiety: Studi pada Mahasiswa Tahun Pertama
Authors: Fauzia Detha , Pebriani Lucia Voni 
Published: September 2024

Mahasiswa tahun pertama sering merasakan academic anxiety akibat perubahan yang dirasakan dari sekolah menengah ke perkuliahan sehingga membutuhkan dukungan sosial untuk menghadapinya. Studi ini bertujuan untuk meneliti peran perceived social support terhadap academic anxiety mahasiswa tahun pertama di Universitas Padjadjaran. Penelitian ini menggunakan pendekatan kuantitatif noneksperimental dengan metode analisis hubungan korelasional berarah melalui analisis regresi. Perolehan data dilakukan menggunakan kuesioner daring dengan partisipan yaitu 203 mahasiswa tahun pertama Universitas Padjadjaran (58.6% perempuan dan 37.4% laki-laki). Alat ukur yang digunakan pada penelitian ini adalah alat ukur Multidimensional Scale of Perceived Social Support untuk variabel perceived social support dan Skala Kecemasan Akademik untuk variabel academic anxiety. Kedua alat ukur telah dibuktikan validitas dan reliabilitasnya dalam penelitian sebelumnya maupun pada penelitian ini. Hasil penelitian menunjukkan bahwa perceived social support berperan secara signifikan terhadap academic anxiety (p< .00; R² = .104). Selain itu, dimensi-dimensi perceived social support juga berkorelasi dengan academic anxiety. Namun, hanya dukungan dari keluarga yang memiliki peran signifikan terhadap academic anxiety dibandingkan teman dan significant others (p <.005). Hal ini mungkin terjadi karena hubungan yang jauh lebih stabil dengan keluarga membuat dukungan yang dirasakan menjadi lebih berharga. Temuan penelitian ini dapat digunakan sebagai dasar pertimbangan intervensi di lingkungan akademik. Fokus pada meningkatkan dukungan sosial dari keluarga dapat menjadi strategi efektif untuk mengurangi kecemasan akademik di kalangan mahasiswa.
Gambaran Gaya Hidup Sehat Dewasa Indonesia dalam Perspektif Sosiodemografi
Authors: Aulia Dina , Siswadi Ahmad Gimmy Prathama , Abidin Fitri Ariyanti 
Published: September 2024

Penerapan gaya hidup yang sehat terbukti memiliki dampak positif bagi kesehatan fisik, psikologis, bahkan sosial. Menerapkan gaya hidup yang sehat menjadi penting terutama pada individu dewasa yang sedang memegang kendali penuh atas kehidupan dan lingkungannya. Di beberapa negara ditemukan hanya sebagian kecil individu dewasa yang menerapkan gaya hidup sehat, namun di Indonesia belum ada penelitian terkait ini. Profil kesehatan di Indonesia sering kali hanya berfokus pada prediksi kematian dan kejadian penyakit. Penelitian ini bertujuan untuk melihat tingkat gaya hidup sehat individu dewasa berdasarkan karakteristik sosiodemografi (usia, jenis kelamin, status pernikahan, pendidikan, pekerjaan, pendapatan ekonomi, jumlah anak, usia anak pertama, serta kondisi medis atau psikologis). Pemilihan sampel dilakukan dengan metode convenience sampling dan pengambilan data dilakukan dengan menyebarkan survei daring menggunakan software PsyToolkit. Gaya hidup sehat diukur menggunakan kuesioner Health-Promoting Lifestyle Profile-II (HPLP-II) versi bahasa Indonesia dengan reliabilitas sebesar α = 0.945. Analisis data dilakukan dengan uji beda Mann-Whitney dan Kruskal Wallis. Penelitian ini melibatkan 223 orang dewasa (18 hingga 63 tahun). Secara keseluruhan, hasil memperlihatkan bahwa 43.49% partisipan memiliki gaya hidup sehat yang sedang dan 48.43% memiliki gaya hidup sehat yang baik. Penelitian menemukan bahwa usia dan pendapatan ekonomi merupakan karakteristik sosiodemografi yang dapat memengaruhi perbedaan tingkat gaya hidup sehat.
Prediction of Machine’s Centre of Gravity Dislocation with Monte Carlo Simulation
Authors: Rédl Jozef , Boyko Grigory , Kalantari Davood 
Published: September 2024

Abstract
The estimation of machine‘s centre of gravity (COG) dislocation is presented in this article. Various types of agricultural tractors‘ parameters were analysed. Their parameters such as track width in the range of 〈1222 mm, 1900 mm〉 and COG height in the range of 〈830 mm, 1340 mm〉 are known from the reports of OECD tests. The static stability of the machine is defined by the critical angle of labile equilibrium or critical overturning angle in static disposition, which is determined from measurement on the tilt table. The critical overturning angle can be calculated from the known parameters of COG dislocation. The critical overturning angle for each analysed machine can be evaluated from the obtained dataset. The mean and standard deviation of parameters were used as input parameters into Monte Carlo simulation (MCS). The MCS method was used for the estimation of the critical overturning angle and height of COG for 2500 data. Simulation was performed using a Mathcad® Prime 9.0 software. The basic statistical analysis was performed using a Spyder software in the Python language. The polynomial approximation equation was set up, and then COG heights were calculated. The critical overturning angle was calculated from the real and simulated parameters. The functions of the critical overturning angle were compared, and the fit of approximation was evaluated by the R
2 parameter. The designed model was verified by the F-distribution test.