bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-Effectiveness of Pediatric Cancer Treatment in Tanzania: An Economic Analysis
Authors: Saxton Anthony T. , Bhattacharya Manisha , Masalu Nestory , Rice Henry E. , Schroeder Kristin 
Published: April 2017

Abstract 52 Background: Despite the high burden of pediatric cancer in low- and middle-income countries, the number of facilities at which children can obtain treatment remains distressingly low. Understanding the costs and economic value of pediatric cancer treatment may assist policy makers to maximize the value of investments in health with informed resource allocation decisions. We examined the direct and indirect costs, cost-effectiveness, and societal economic benefit of diagnosing and treating children with cancer in Tanzania at the Bugando Medical Center, one of only two hospitals in the country with a pediatric oncology unit. Methods: A retrospective chart review of hospital admissions and clinic visits from January 2010 to August 2014 was performed. Costs were recorded for all items that were billed to the patient for laboratory studies, medications, imaging, pathology, surgeries, and hospital stay. Travel costs were estimated for each patient on the basis of a self-reported home address. All costs were converted from Tanzanian shillings to 2016 US dollars. Health outcomes were measured as disability-adjusted life-year (DALY) averted. We calculated the cost-effectiveness ratio of treatment versus performing no intervention as well as the societal economic benefit using a human capital approach and considering the per capita gross national product in Tanzania. Results: We identified costs for a subset of 127 patients, 64% of which were male (n = 81). Mean age at first clinical presentation was 6.9 years. Mean cost for treatment was $218 ± $145, with an average of 10.4 ± 8.9 DALYs averted per patient. Total cost-effectiveness ratio was $21/DALY, and the mean societal economic benefit was $27,118 ± $23,412. Conclusion: Our findings show that pediatric cancer treatment in Tanzania is cost-effective and offers substantial economic value. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST No COIs from the authors.
Όψεις του πλατωνικού έρωτα στο Συμπόσιο και τον Φαίδρο
Authors: Στάμος (Fotis Stamos) Φώτης 
Published: April 2017

The platonic Love [Eros]; a matter that raised and keeps raising still thoughts and talks; a crucial matter for Plato himself. But what really is it? To whom or what does it turn to; What is this that it intends for? Guided by Plato’s work itself, and especially by Symposium and the first part of the extensive Phaidros, I intend to bring to the surface the most crucial views of platonic Love. Through the successive speeches in Symposium; through the many encomiums made by each and everyone of Socrates speakers, in the end, the philosopher does not simply speak about Love, but he discloses it. Same goes in Phaidros; had the speech contests taken place between Socrates and Lysias, the philosopher, had his face uncovered – through his first speech Socrates had his face covered in order not to commit hubris –, tergiversates and reveals that furious state to its whole. Three will be the main points the following paper will try to expound: i) What is the so named platonic Love? ii) What does the lover desire to conquer? iii) How does Plato speaks to us about it through his work?
Can we predict which dysplastic hips will require acetabular augmentation during total hip arthroplasty based on pre-operative radiographs?
Authors: Marsh A. G. , Nisar A. , El Refai M. , Patil S. , Meek R. M. D. 
Published: April 2017

Aims The purpose of this study was to evaluate whether an innovative templating technique could predict the need for acetabular augmentation during primary total hip arthroplasty for patients with dysplastic hips. Patients and Methods We developed a simple templating technique to estimate acetabular component coverage at total hip arthroplasty, the True Cup: False Cup (TC:FC) ratio. We reviewed all patients with dysplastic hips who underwent primary total hip arthroplasty between 2005 and 2012. Traditional radiological methods of assessing the degree of acetabular dysplasia (Sharp’s angle, Tönnis angle, centre-edge angle) as well as the TC:FC ratio were measured from the pre-operative radiographs. A comparison of augmented and non-augmented hips was undertaken to determine any difference in pre-operative radiological indices between the two cohorts. The intra- and inter-observer reliability for all radiological indices used in the study were also calculated. Results Of the 128 cases reviewed, 33 (26%) needed acetabular augmentation. We found no difference in the median Sharp’s angle (p = 0.10), Tönnis angle (p = 0.28), or centre-edge angle (p = 0.07) between the two groups. A lower TC:FC ratio was observed in the augmented group compared with the non-augmented group (median = 0.66 versus 0.88, p < 0.001). Intra-observer reliability was found to be high for all radiological indices analysed (interclass correlation coefficient (ICC) > 0.7). However, inter-observer reliability was more variable and was only high for the TC: FC ratio (ICC > 0.7). Conclusion The TC: FC ratio gives an accurate estimate of acetabular component coverage. It can help predict which dysplastic hips are likely to need acetabular augmentation at primary total hip arthroplasty. It has high intra- and inter-observer reliability. Cite this article: Bone Joint J 2017;99-B:445–50.
Total hip arthroplasty using a monobloc cementless femoral stem for patients with childhood Perthes’ disease
Authors: Lee K. H. , Jo W-L. , Ha Y. C. , Lee Y. K. , Goodman S. B. , Koo K. H. 
Published: April 2017

AimsModular or custom-made femoral components have been preferred for total hip arthroplasty (THA) in patients with a history of Perthes’ disease because of the distortion in the anatomy of the proximal femur. However, it has not been established whether a monobloc cementless stem will fit the distorted proximal femur or whether the results of the procedure are satisfactory in this group of patients.Patients and MethodsWe reviewed 68 consecutive patients who had undergone THA for childhood Perthes’ disease between June 2003 and December 2008. There were 35 men and 33 women with a mean age of 48 years (16 to 73) at the time of index arthroplasty. Their mean body mass index was 24.4 (18.3 to 32.9). Of the 68 hips, 32 were classified as Stulberg class III and 36 as class IV. The mean pre-operative shortening of the affected leg was 17.2 mm (5 to 34). The minimum follow-up was five years (mean 8.5 years; 5.2 to 10).ResultsAn intra-operative calcar fracture occurred in eight hips (11.8%) and was successfully treated by cerclage wiring. The mean stem version was 14.6° (-2.3 to 30; standard deviation (sd) 7.3). The mean acetabular component abduction was 40.2° (23.7 to 56.0; sd 6.5) and the mean anteversion 28.3° (6.4 to 43.0; sd 7.6), respectively. The mean follow-up was 8.5 years (5.2 to 10). No dislocations occurred and no hips were revised during the course of the study. At final follow-up, the mean Harris Hip Score was 91 points (59 to 100) and the mean University of California, Los Angeles activity score was 3.2 (2 to 8).ConclusionMonobloc cementless stems reliably restore the anatomy in Perthes’ disease at THA without the need for custom-made or modular implants. Cite this article: Bone Joint J 2017;99-B:440–444.
Multimodal infiltration of local anaesthetic in total knee arthroplasty; is posterior capsular infiltration worth the risk?
Authors: Pinsornsak P. , Nangnual S. , Boontanapibul K. 
Published: April 2017

Aims Multimodal infiltration of local anaesthetic provides effective control of pain in patients undergoing total knee arthroplasty (TKA). There is little information about the added benefits of posterior capsular infiltration (PCI) using different combinations of local anaesthetic agents. Our aim was to investigate the effectiveness of the control of pain using multimodal infiltration with and without infiltration of the posterior capsule of the knee. Patients and Methods In a double-blind, randomised controlled trial of patients scheduled for unilateral primary TKA, 86 were assigned to be treated with multimodal infiltration with (Group I) or without (Group II) PCI. Routine associated analgesia included the use of bupivacaine, morphine, ketorolac and epinephrine. All patients had spinal anaesthesia and patient-controlled analgesia (PCA) post-operatively. A visual analogue scale (VAS) for pain and the use of morphine were recorded 24 hours post-operatively. Side effects of the infiltration, blood loss, and length of stay in hospital were recorded. Results There were no statistically significant differences between the groups in relation to: VAS pain scores in the first 24 hours post-operatively (p = 0.693), the use of morphine in the PCA (p = 0.647), blood loss (p = 0.625), and length of stay (p = 0.17). There were no neurovascular complications in either group. Conclusion The multimodal infiltration of local anaesthetic with infiltration of the posterior capsule did not provide significant added analgesic benefits or reduce the use of morphine after TKA. Multimodal infiltration is a satisfactory technique for the management of pain in these patients without the attendant risks of PCI. Cite this article: Bone Joint J 2017; 99-B:483–8.
Prognostic factors for long-term outcome of chronic slipped capital femoral epiphysis treated with fixation in situ
Authors: Terjesen T. , Wensaas A. 
Published: April 2017

Purpose Predictive factors for long-term outcome after in situ fixation for chronic slipped capital femoral epiphysis (SCFE) have so far not been systematically analysed. The aims of this study were to define predictors for long-term outcome and to assess the association between initial grade of slipping and post-slip deformities. Methods We studied 51 patients (60 hips) with chronic SCFE treated with in situ fixation. There were 31 males and 20 females with a mean age of 12.9 years. The mean follow-up was 39.0 years (21.1 to 56.8). Post-slip deformity was defined as abnormal alpha (a) angles in anteroposterior (AP) and lateral radiographs; AP angle of 74° and lateral angle of 63° were used as cutoffs between normal and abnormal α-angles. Harris hip score (HHS) less than 85 points was classified as a poor clinical outcome and osteoarthritis was a poor radiographic outcome. Results The mean slip angle was 31.7° (12° to 77°). The mean AP α-angle was 67.4° (36° to 111°) and the mean lateral α-angle was 57.1° (22° to 104°). Post-slip deformities developed in almost one-third of hips with a mild degree of slipping and in about half the hips with more pronounced degrees of slipping. The long-term outcome was good in 40 hips (67%) and poor in 20 hips. A small AP α-angle was the only independent prognostic factor for a good combined clinical and radiographic outcome. Conclusion Post-slip deformity, defined as an abnormally high AP α-angle, is the most important prognostic factor for poor long-term clinical and radiographic outcome in chronic SCFE treated with in situ fixation.
Femoral and acetabular re-alignment in slipped capital femoral epiphysis
Authors: Leunig M. , Manner H. M. , Turchetto L. , Ganz R. 
Published: April 2017

New pathophysiological insights Based on improved knowledge of the vascular supply of the proximal femur, a safe surgical dislocation of the hip joint was established allowing direct insights to the pathomorphological malfunctioning of the joint. One insight was that slipped capital femoral epiphysis (SCFE) impingement leads to substantial damage of the chondrolabral rim area, even in the presence of minor slips. A further surgical development was the extended retinacular flap allowing for correction of the deformity with calculable risk for iatrogenic necrosis. Consecutive surgical concept In 20 years of experience, a treatment concept for SCFE could be established which replaces classic pinning in situ and indirect correction of the deformity with subcapital re-alignment when the physis is still open, with true femoral neck osteotomy for hips with closed physis. Pinning in situ still has a place in minor slips but should be combined with open or arthroscopic recreation of an anterior metaphyseal waisting. Unexpected complication Loss of joint stability is a rare complication of anatomic re-alignment. It can be disease-related when the impingement has induced severe destruction of acetabular cartilage. It can be related to the surgical procedure, especially when the neck was excessively shortened and refixation of the trochanter was not advanced. Finally, in cases with severe and long-lasting deformity, the acetabulum may undergo adaptive flattening, being the cause of joint destabilisation with the correction of the deformity. Advancement of the greater trochanter and/or peri-acetabular osteotomy may be discussed to restabilise the joint.
Interaction of Magnesium Cations with Dioctahedral Smectites under HLRW Repository Conditions
Authors: Kaufhold S. , Dohrmann R. , Ufer K. 
Published: April 2017

AbstractIn some real and up-scale tests using high-level radioactive waste (HLRW), Mg accumulation was observed in smectites at the contact of heated Fe or Cu metal tubes. It is important to understand why Mg accumulated in order to model the long term performance of bentonites in HLRW systems. In some of these tests, an increased number of trioctahedral domains was measured in the smectites using X-ray diffraction (XRD) and infrared spectroscopy (IR). The trioctahedral domains either formed by the dissolution/precipitation of smectites or by the addition of Mg through a solid-state reaction similar to the Hofmann-Klemen effect. The Hofmann-Klemen effect is used in the Greene-Kelly test to distinguish montmorillonites from beidellites. Many studies have been carried out about Li-uptake by smectites, but Mg was rarely taken into account. The present study was, therefore, undertaken to compare the interactions of different bentonites with Li and Mg under various conditions. A significant CEC decrease was found for Li- and Mg-saturated bentonite samples after heating at 250°C under dry conditions. The extent of this CEC reduction depended on the octahedral to tetrahedral charge ratio and was smaller for Mg-saturated samples than Li-saturated samples. This finding proved that it is much more difficult for Mg to enter octahedral vacancies than Li, which probably can be explained by the larger hydration energy and/or slightly larger radius of Mg. The relationship between CEC reduction and the octahedral/tetrahedral charge ratio of both Li- and Mg-saturated samples, however, suggests a similar process. The Mg that can reside at the bottom of the pseudohexagonal holes would not explain this relationship. The important result with respect to understanding HLRW bentonite performance, on the other hand, is that Mg fixation only occurs under dry conditions and that Mg fixation acts as a sink for Mg and, hence, leads Mg to diffuse towards the heated metal surface.
Erarbeitung von Bestands-Notfallunterlagen
Authors: Süess Ruth 
Published: April 2017

Zusammenfassung
Die Notwendigkeit eines Notfallplans für Bestände von Bibliotheken mit Archivauftrag und anderen sammelnden Institutionen wird kaum angezweifelt. Auch liest man regelmäßig in der Fachliteratur über die Wichtigkeit von Bestands-Notfallunterlagen. Dennoch haben viele Bibliotheken keinen aktuellen Notfallplan, welchen sie im Ernstfall einfach aus der Schublade ziehen könnten. Im vorliegenden Beitrag wird der Prozess des Erarbeitens der Bestands-Notfallunterlagen für die Universitätsbibliothek St. Gallen aus Sicht der Erstellerin beschrieben.
An adaptive control scheme for hyperbolic partial differential equation system (drilling system) with unknown coefficient
Authors: Farahani Hamed Shirinabadi , Talebi Heidar Ali , Baghermenhaj Mohammad 
Published: April 2017

Abstract
The adaptive boundary stabilization is investigated for a class of systems described by second-order hyperbolic PDEs with unknown coefficient. The proposed control scheme only utilizes measurement on top boundary and assume anti-damping dynamics on the opposite boundary which is the main feature of our work. To cope with the lack of full state measurements, we introduce Riemann variables which allow us reformulate the second-order in time hyperbolic PDE as a system with linear input-delay dynamics. Then, the infinite-dimensional time-delay tools are employed to design the controller. Simulation results which applied on mathematical model of drilling system are given to demonstrate the effectiveness of the proposed control approach.
The Relationship between Economic Development and Fatal Occupational Accidents: Evidence from Turkey
Authors: Çolak Olcay , Palaz Serap 
Published: April 2017

Abstract
Occupational accidents are among the most important issues of the agenda of working life in Turkey recently. Recently the causes and consequences of occupational accidents which are related to human, occupational and environmental factors have received great attention from the researchers but it has been paid little attention to focused on economic factors. The purpose of this paper is to make a contribution to redressing this gap by examining the relationship between fatal occupational accidents and economic development over the period of 1980 to 2012 for Turkey. In this context, bounds testing approach which is also known as autoregressive distributed lag model is performed. The results indicate the existence of positive relationship between gross domestic product per capita and fatal occupational accidents in the short-run while in the long run this turns out to be in a negative way via economic growth and changes in structure of the economy.
Macroeconomic Dimensions in the Clusterization Processes: Lithuanian Biomass Cluster Case
Authors: Navickas Valentinas , Svazas Mantas 
Published: April 2017

Abstract
The Future production systems’ increasing significance will impose work, which maintains not a competitive, but a collaboration basis, with concentrated resources and expertise, which can help to reach the general purpose. One form of collaboration among medium-size business organizations is work in clusters. Clusterization as a phenomenon has been known from quite a long time, but it offers simple benefits to researches at micro and medium levels. The clusterization process evaluation in macroeconomic dimensions has been comparatively little investigated. Thereby, in this article, the clusterization processes is analysed by concentrating our attention on macroeconomic factor researches. The authors analyse clusterization’s influence on country’s macroeconomic growth; they apply a structure research methodology for clusterization’s macroeconomic influence evaluation and propose that clusterization processes benefit macroeconomic analysis. The theoretical model of clusterization processes was validated by referring to a biomass cluster case. Because biomass cluster case is a new phenomenon, currently there are no other scientific approaches to them. The authors’ accomplished researches show that clusterization allows the achievement of a large positive slip in macroeconomics, which proves to lead to a high value added to creation, a faster country economic growth, and social situation amelioration.
The Effect of Credit Risk and Capital Adequacy on the Profitability of Rural Banks in the Philippines
Authors: Mendoza Rufo , Rivera John Paolo R. 
Published: April 2017

AbstractThis paper examines the credit risk and capital adequacy of the 567 rural banks in the Philippines to investigate how both variables affect bank profitability. Using the Arellano-Bond estimator, we found out that credit risk has a negative and statistically significant relationship with profitability. However, empirical analysis showed that capital adequacy has no significant impact on the profitability of rural banks in the Philippines. It is therefore necessary for the rural banks to examine more deeply if capital infusion would result in higher profitability than increasing debts. The study also implies that it is imperative for the banks to understand which risk factors have greater impact on their financial performance and use better risk-adjusted performance measurement to support their strategies. Rural banks should establish credit risk management that defines the process from initiation to approval of loans, taking into consideration the sound credit risk management practices issued by regulatory bodies. Moreover, rural banks need to enhance internal control measures to ensure the strict implementation of internal processes on lending operations.
Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?
Authors: Bulat Zorica , Đukić-Ćosić Danijela , Antonijević Biljana , Buha Aleksandra , Bulat Petar , Pavlović Zoran , Matović Vesna 
Published: April 2017

Abstract
The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10 mg kg-1 bw, as aqueous solution of Cd-chloride), and a Cd+Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg-1 bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO3) and perchloric acid (HClO4) (4:1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were observed in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn, Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.
Robust Mpc for Actuator–Fault Tolerance Using Set–Based Passive Fault Detection and Active Fault Isolation
Authors: Xu Feng , Puig Vicenç , Ocampo-Martinez Carlos , Olaru Sorin , Niculescu Silviu-Iulian 
Published: April 2017

Abstract
In this paper, a fault-tolerant control (FTC) scheme is proposed for actuator faults, which is built upon tube-based model predictive control (MPC) as well as set-based fault detection and isolation (FDI). In the class of MPC techniques, tubebased MPC can effectively deal with system constraints and uncertainties with relatively low computational complexity compared with other robust MPC techniques such as min-max MPC. Set-based FDI, generally considering the worst case of uncertainties, can robustly detect and isolate actuator faults. In the proposed FTC scheme, fault detection (FD) is passive by using invariant sets, while fault isolation (FI) is active by means of MPC and tubes. The active FI method proposed in this paper is implemented by making use of the constraint-handling ability of MPC to manipulate the bounds of inputs.
After the system has been detected to become faulty, the input-constraint set of the MPC controller is adjusted to actively excite the system for achieving FI guarantees on-line, where an active FI-oriented input set is designed off-line. In this way, the system can be excited in order to obtain more extra system-operating information for FI than passive FI approaches.
Overall, the objective of this paper is to propose an actuator MPC scheme with as little as possible of FI conservatism and computational complexity by combining tube-based MPC and set theory within the framework of MPC, respectively.
Finally, a case study is used to show the effectiveness of the proposed FTC scheme.