bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antisense Oligodeoxynucleotide Technology: Potential Use for the Treatment of Malignant Brain Tumors
Authors: Engelhard Herbert H. 
Published: August 2017

Background:Antisense oligodeoxynucleotides (ODNs) have been proposed as a new therapy for patients with cancer, including malignant brain tumors. Antisense ODNs are taken up by tumor cells and selectively block gene expression. Use of ODNs for brain tumors is attractive due to their theoretical specificity, relative ease of production and, to date, paucity of reported adverse effects. This article presents current information regarding antisense ODNs and their possible future use for the treatment of brain tumors.Methods:The available published experimental and clinical information regarding antisense ODN treatment of glioblastoma cells and administration into the central nervous system (CNS) was reviewed. Other clinically relevant information pertaining to the molecular biology of antisense ODNs was also collected and summarized.Results:Targets for antisense ODN therapy in malignant glioma cells have included c-myc, c-myb, c-sis, c-erb B, CD44, p34cdc2, bFGF, PDGF, TGF-beta, IGF-1, PKC-alpha tumor necrosis factor, urokinase, and S100beta protein. Few in vivo studies of ODN treatment of brain tumors have yet been reported. Systemically administered ODNs enter the brain only in extremely small quantities; therefore, microinfusion into the brain has been recommended.Conclusions:Antisense ODNs have been used successfully to block glioblastoma gene expression in vitro and expression of multiple genes within the CNS of experimental animals. Upcoming clinical trials will address the safety of antisense ODN use against malignant brain tumors.
Management of Myeloma: Current and Future Approaches
Authors: Oken Martin M. 
Published: August 2017

Background The treatment of multiple myeloma, relatively stagnant for many years, appears to be entering a promising era for improvement. This paper reviews treatment interventions available for patients with multiple myeloma to indicate a standard approach and to evaluate the spectrum of current standard therapy. Methods The author reviews published literature on the treatment of multiple myeloma. Both journal articles and papers presented at national and international meetings are utilized. Results Intensive combination chemotherapy offers relatively modest improvement over standard melphalan plus prednisone, but the use of interferon for maintenance therapy lengthens response duration and possibly survival. High-dose chemotherapy with stem-cell transplantation is a relatively safe and effective treatment modality for patients under 70 years of age at first relapse. Studies in progress will determine its role in first response consolidation. Use of hematopoietic growth factors, prophylactic antibiotics, and bisphosphonate treatment of lytic bone disease has diminished disease morbidity. Conclusions While cure of multiple myeloma remains elusive and 10-year survival is still uncommon, newer treatment approaches offer better control of disease manifestations and perhaps a real opportunity to prolong functional life. Future treatments that will address minimal residual disease may improve long-term survival.
Pharmacoeconomics of Cancer Therapy
Authors: Beltz Susan E. , Yee Gary C. 
Published: August 2017

BackgroundIn 1990, annual costs of the diagnosis and treatment of cancer reached nearly $100 billion and currently constitutes approximately 10% of health care expenditures in the United States. As new and often more expensive therapies for cancer treatment become available, the health care decision- maker must consider the cost effectiveness of the therapy.MethodsKey principles of economic analyses and the inherent differences among these analyses are reviewed.ResultsWhile pharmacoeconomic analyses are increasingly being used in treatment decision-making, several issues relating to study design, data collection, and research methods are controversial.ConclusionsPharmacoeconomics analyses are necessary in the current health care environment, but the assumptions used within the analyses warrant careful evaluation.
Chemotherapy for Advanced Gastric Cancer: Focus on New Agents and Combinations
Authors: Murad André M. 
Published: August 2017

Background Although many treatments for advanced gastric cancer have been developed, systemic therapy remains elusive. Methods The author reviewed data on recent phase II and III trials of the main new agents and combinations. Results Chemotherapy appears to improve survival of patients with advanced disease, albeit slightly. New drugs that might improve response rates and survival include the taxanes. Conclusions New combinations, including the taxanes, must be designed and evaluated to further improve the outcome for patients with advanced gastric cancer.
Seasonal affective disorder and non-seasonal affective disorders: Results from the NESDA study
Authors: Winthorst Wim H. , Roest Annelieke M. , Bos Elisabeth H. , Meesters Ybe , Penninx Brenda W.J.H. , Nolen Willem A. , de Jonge Peter 
Published: August 2017

BackgroundSeasonal affective disorder (SAD) is considered to be a subtype of depression.AimsTo compare the clinical picture of SAD to non-seasonal affective disorders (non-SADs).MethodDiagnoses according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) were established in 2185 participants of the Netherlands Study of Depression and Anxiety. The Seasonal Pattern Assessment Questionnaire was administered to diagnose SAD. Symptoms of depression and anxiety were measured with the Inventory of Depressive Symptoms, the Beck Anxiety Inventory and the Fear Questionnaire.ResultsParticipants with SAD, participants with a lifetime bipolar disorder and participants with a lifetime comorbid anxiety and depressive disorder scored highest in terms of psychopathology in the past year. The seasonal distribution of major depressive episodes was not different for participants with or without SAD.ConclusionsSAD may be a measure of severity of depression with a subjectively perceived worsening of symptoms in the winter months.
The role of stochastic thermal environments in modulating the thermal physiology of an intertidal limpet, Lottia digitalis
Authors: Drake Madeline J. , Miller Nathan A. , Todgham Anne E. 
Published: August 2017

ABSTRACT
Much of our understanding of the thermal physiology of intertidal organisms comes from experiments with animals acclimated under constant conditions and exposed to a single heat stress. In nature, however, the thermal environment is more complex. Aerial exposure and the unpredictable nature of thermal stress during low tides may be critical factors in defining the thermal physiology of intertidal organisms. In the fingered limpet, Lottia digitalis, we investigated whether upper temperature tolerance and thermal sensitivity were influenced by the pattern of fluctuation with which thermal stress was applied. Specifically, we examined whether there was a differential response (measured as cardiac performance) to repeated heat stress of a constant and predictable magnitude compared with heat stress applied in a stochastic and unpredictable nature. We also investigated differences in cellular metabolism and damage following immersion for insights into biochemical mechanisms of tolerance. Upper temperature tolerance increased with aerial exposure, but no significant differences were found between predictable treatments of varying magnitudes (13°C versus 24°C versus 32°C). Significant differences in thermal tolerance were found between unpredictable trials with different heating patterns. There were no significant differences among treatments in basal citrate synthase activity, glycogen content, oxidative stress or antioxidants. Our results suggest that aerial exposure and recent thermal history, paired with relief from high low-tide temperatures, are important factors modulating the capacity of limpets to deal with thermal stress.
Impact of the quantity of intradiscal cement leak on the progression of intervertebral disc degeneration
Authors: Jamjoom B , Patel S , Bommireddy R , Klezl Z 
Published: August 2017

Introduction We aim to assess the impact of the quantity of intradiscal cement leak during kyphoplasty on the rate of progression of degenerative changes in the affected disc. Methods Of 316 kyphoplasty procedures, we identified 32 episodes of intradiscal cement leak in 26 patients. The quantity of cement leaked was graded from I to IV. Disc degenerative changes were assessed at presentation and follow-up using radiographical scoring and magnetic resonance imaging (MRI) grading systems. Data for low-grade leaks (grade I) were compared with the medium- and high-grade leaks (grades II–IV) using a chi-squared test. Results Median follow-up radiographic and MRI assessments were made at 18 and 21 months, respectively. Medium- and high-grade leaks were associated with a significantly higher radiographic disc degeneration scores compared with low-grade leaks (P = 0.04295) but no difference was found in MRI disc degeneration grades and in adjacent vertebral fracture rates. Conclusions Our findings indicate that the quantity of cement leaking into the disc space significantly influences the rate of progression of disc degeneration.
Audience engagement and impact: Ethical considerations in art-based health research
Authors: Guillemin Marilys , Cox Susan 
Published: August 2017

Abstract
Art-based research presents epistemological benefits and challenges for researchers and artists. There are also significant ethical implications for audiences as well as participants and researchers. We argue that it is important to consider who is in the audience and how to minimize potentially harmful effects of the work. This includes issues of privacy and confidentiality arising from incorporation of participants’ stories into the art form and the need to offer reassurance to audience members who may believe they recognize aspects of themselves or someone they know in the production. It also highlights the need for researchers to establish respectful terms of engagement for audiences who may offer a variety of interpretations to the artistic work. We point to possible ways that researchers and artists can address these ethical tensions to ensure that art-based health research is ethically rigorous as well as being creatively engaging.
Re-conceptualizing ‘impact’ in art-based health research
Authors: Parsons Janet A. , Gladstone Brenda M. , Gray Julia , Kontos Pia 
Published: August 2017

Abstract
This article explores the notion of ‘impact’ in art-based health research (ABHR), and how we might re-conceptualize it through the kind of work ABHR ‘does’ in generating and disseminating knowledge. We explore ‘impact’ from a critical qualitative perspective, leveraging findings from a study based on interviews with ABHR researchers/artists/trainees. We focus on their reflections related to ‘impact’, and informed by our own experiences of producing/evaluating ABHR in diverse genres. We argue for a conceptualization of impact that moves beyond an exclusive positivist and biomedical concern with whether certain ABHR ‘interventions’ (defined here as processes/products of an ABHR study) work in generalizable ways, to one that focuses on context as well as processes of development, implementation and engagement. How will we know if a particular ABHR project ‘worked’? What kinds of ‘work’ do the products of ABHR do? How might we, or should we, tease out ‘process’ from ‘product’? In exploring these questions, we problematize what is meant by ‘impact’ and what we can expect from the knowledge generated and its translation via varied artistic genres.
Hybrid health research: Assembling an integrated arts/science methodological framework
Authors: Edwards Geoffrey , Arfaoui Afnen , McLaren Coralee , McKeever Patricia 
Published: August 2017

Abstract
Within the effort to create a form of enquiry that is both, and neither, art and science, we explore methodologies at the intersection of these activities. The methodologies under study are grounded in embodied contemporary philosophical writings – the work of Gibson, Deleuze and Guattari and Whitehead have drawn our particular interest. Using examples drawn from projects undertaken over recent years, we illustrate how these philosophies can be used to develop a formal methodological framework. We then go on to investigate to what extent the elements that form this framework are also found in a corpus of texts obtained from interviews with researchers and students working in arts-based health research. The results, which largely confirm the lessons drawn, suggest that the proposed framework may have broader generality.
Ineffable knowledge: Tensions (and solutions) in art-based research representation and dissemination
Authors: Boydell Katherine M. , Hodgins Michael J. , Gladstone Brenda M. , Stasiulis Elaine 
Published: August 2017

Abstract
This article draws upon an art-based health research (ABHR) study that examines the work of health/social science researchers and artists who use a wide variety of art genres to create and disseminate scientific health-based research. The intent of their work is to reduce the knowledge to action gap as well as to enable engagement with the research findings on the part of the target audience. With respect to the use of art genres to disseminate research findings, the representation of the source material often poses a dilemma for both artists and researchers alike, particularly vis-à-vis the extent to which the research is made explicit. We consider here the methodological and epistemological expectations of the ABHR community (both artists and researchers) regarding dissemination of research findings. We detail the tensions experienced in creative teams engaged in ABHR projects when deciding exactly how much information about the research should be provided to the audience and then move on to highlight the strategies identified by our study participants to address these tensions.
Stories as a scientific method in art-based health research
Authors: Cheu Hoi F. 
Published: August 2017

Abstract
In a study that interviewed 36 art-based health researchers, one constant element shines: stories. This article investigates and theorizes the roles and meanings of stories in art-based health research. It discusses how stories can function as part of the scientific method. Built on the epistemological foundation of story as a way of complex scientific modelling, the article introduces the use of literary theory for the critical enquiry into the application of art in health research, arguing that art-based research is more than using artwork for data collection and knowledge translation. Story-telling and art-making, as it proposes, is a process of modelling real social change through the imaginary space.
An introduction and overview of research and knowledge translation practices in a pan-Canadian art-based health research study
Authors: Hodgins Michael J. 
Published: August 2017

Abstract
This article provides a brief overview of the emergence of art-based health research and describes a pan-Canadian study exploring the experience of researchers, artists and trainees engaged in this work. Research participants are described and specific research projects explicating the array of art-based knowledge creation and translation practices are outlined as exemplars of this work. In order to highlight the diversity of art-based research, four unique projects are presented, which exemplify the art genres represented in the study: performative, literary, visual and multi-media.
Art-based research as waves of embodied engagement: Reflections on ‘Across the Tamar’
Authors: Carless David , Douglas Kitrina 
Published: August 2017

Abstract
‘Across the Tamar’ began as a research project exploring the physical activity, health and lifestyle of women over 60 in Cornwall, UK. It evolved into a multidimensional, long-running art-based health research project incorporating songs, stories and poetry into live performances, an audio CD and series of YouTube films. In this article, we share some dialogical reflections on our journey through the project to suggest that an important contribution of art-based research is to facilitate – or expect – multiple waves of embodied engagement. We explore three waves of embodied engagement that occurred during our work on the ‘Across the Tamar’ project.
Theatre with veterans: Transition and recovery
Authors: Belliveau George 
Published: August 2017

Abstract
This article shares research from an initiative where researchers in counselling psychology and theatre education collaborated with military veterans to produce the play Contact!Unload. Researchers and community members participated with returning veterans in a series of drama-based workshops that led to the production. The collective process was an expressive vehicle for military men to publicly reinterpret their struggles and experiences of transitioning from active service overseas to civilian life in ways that build resilience. The article offers insights on how researchbased theatre as a methodological approach invites researchers to artistically present their understandings in a performative manner.
Reviews
Authors: Duque Monica , Wynn Tiffany , Feniger-Schaal Rinat 
Published: August 2017

Abstract
DBT-Informed Art Therapy, Susan M. Clark (2016) London and Philadelphia: Jessica Kingsley Publishers, 344 pp., ISBN: 9781849057332, p/bk $39.95
With Nature in Mind the Ecotherapy Manual for Mental Health Professionals, Andy McGeeny (2016) Philadelphia, PA: Jessica Kingsley Publishers 336 pp. ISBN: 9781785920240 p/bk, £19.99
On the Edge: From the Margins to the Mainstream, 2016 Annual Conference, British Association of Dramatherapy (BADth), Gloucestershire, UK, 9–11 September 2016
Al-Khawaja Yanni (Yanni the Westerner): An Example of Muslim-Christian Tolerance in Jeddah during the 20th Century
Authors: Al-Ghamdi Hassna 
Published: August 2017

Abstract
This paper handles a unique example of religious tolerance and Christian-Muslim coexistence in one of the most conservative Islamic societies; the Saudi Arabian society, by going through the story of Khawaja Yeni, the Greek merchant who lived in the city of Jeddah in the middle of the twentieth century, integrated with its people, formed extensive relations with its Muslim people, and was able to remain vivid in the collective memory of its inhabitants despite his death has Christian decades ago. The Yeni model represents a model of mutual understanding and coexistence between Islamic and Christian cultures. It would not have mattered if the story had been in another Islamic country, but it was in Saudi Arabia and in the city of Jeddah, which is part of the emirate of Mecca, the holy capital of Muslims, this has made the story of Yeni eye-catching and intriguing. Therefore, I saw fit to give that subject a special care and a thorough inquest in order to capture the details of the social, cultural and religious life experienced and interacted with by this Greek merchant. In the absence of official documentation of the details of public life in the mid-20th century, the stories and news about Yeni remained only circulating amongst the inhabitants of Jeddah, and were not written or collected in an academic research that would have saved them from loss and made them available for specialists to study and analyze. Therefore, I relied on the method of “oral history’s documentation” and I gathered these narratives from the mouths of the men who lived and worked with Yeni. Then I analyzed these narratives and drafted them in an academic form that brings together all the narratives from popular circles about the personality of this wonderful Christian who gave a wonderful example of coexistence and integration into a very conservative Islamic society.
The Linguistic Behaviours of the Pupils of the Elementary Education and the Social Factors that Condition Them: Surveys of the Linguistic Behaviours of the Pupils of Elementary Education
Authors: Birce Gazmira , Demo Esat 
Published: August 2017

Abstract
The purpose of this study is to discover the way of speaking of pupils of elementary education, their linguistic behaviour, their speech, writing and speaking. The study aims to find the slinguistic factors that affect the pupils′ way of speaking, but also to find the other factors such as social factors which affect or limit the student’s speech. The participants in the study are the pupils of elementary school, particularly the pupils of fourth and fifth grades, to study their speech, the factors that affect it and if they speak according to the standard language. The study is conducted with the pupils of the fourth grade of “Dino Ismaili” school, because there is where we both work. We also conducted a conversation with the pupils to see their way of speaking and expression of thoughts. We also filled in some questionnaires in three schools of the city of Fier. The methods that we used are a combination of qualitative and quantitative methods, we used surveys and questionnires. The data of the study revealed that the factors that affect the speech are: age, gender, ethnic group, social background, family and two social factors such as social economic group and the parent’s level of education. Other factors are book reading, TV and other children programs, conversation with peers and parents etc.
A molecular characteristic of the Anatidae mitochondrial control region – a review
Authors: Warzecha Joanna , Fornal Agnieszka , Oczkowicz Maria , Bugno-Poniewierska Monika 
Published: August 2017

Abstract
Mitochondrial DNA (mtDNA) is a molecular tool that is very effective in genetic research, including phylogenetic analysis. The non-coding region is the most variable fragment of mtDNA, showing variability in length and nucleobase composition and containing three domains: two hypervariable peripheral regions and the conserved domain (D-loop) in the middle. The Anseriformes are amongst the best studied avian groups, including approximately 150 species and containing geese, swans, ducks (Anatidae), the Magpie goose (Anseranatidae) and screamers (Anhimidae). The most numerous family is the Anatidae, appearing in close relationships within the phylogenetic branches of the species. There are differences between the non-coding region of the Anatidae in comparison to other avian control regions. In the article presented below the control region sequences and the phylogeny of the Anatidae were reviewed.
RNAi-mediated gene silencing in Rhynchophorus ferrugineus (Oliver) (Coleoptera: Curculionidae)
Authors: Laudani Francesca , Strano Cinzia P. , Edwards Martin G. , Malacrinò Antonino , Campolo Orlando , Abd El Halim Hesham M. , Gatehouse Angharad M. R. , Palmeri Vincenzo 
Published: August 2017

AbstractRNA interference (RNAi) is a powerful strategy for gene function analysis, and it is also widely studied in view of a promising use in pest control. The red palm weevil, Rhynchophorus ferrugineus (Oliver) (Coleoptera: Curculionidae), is one of the most devastating pests of palm in the world. Conventional pest management practices are not adequate to control this insect, thus the development of efficient approaches with minimal environmental impact are needed. In this work, the potential of RNAi in R. ferrugineus has been investigated through the silencing of three different genes (α-amylase, V-ATPase, Ecdysone receptor). For each gene we tested two different doses (1,500 and 5,500 ng) and two delivery techniques (injection and ingestion), evaluating both gene knockdown and mortality on insects. Results show that RNAi mediated gene silencing in R. ferrugineus varies from gene to gene, and that the response is dose-dependent, with stronger effects when dsRNA was administered by injection. In parallel, the same study was carried out with the model organism Tribolium castaneum Herbst (Coleoptera: Tenebrionidae), with results showing a different pattern of response, although the two insects belong to the same order.