bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiplatelet pretreatment and outcomes following mechanical thrombectomy for emergent large vessel occlusion strokes
Authors: Pandhi Abhi , Tsivgoulis Georgios , Krishnan Rashi , Ishfaq Muhammad F , Singh Savdeep , Hoit Daniel , Arthur Adam S , Nickele Christopher , Alexandrov Andrei , Elijovich Lucas , Goyal Nitin 
Published: December 2017

BackgroundFew data are available regarding the safety and efficacy of antiplatelet (APT) pretreatment in acute ischemic stroke (AIS) patients with emergent large vessel occlusions (ELVO) treated with mechanical thrombectomy (MT). We sought to evaluate the association of APT pretreatment with safety and efficacy outcomes following MT for ELVO.MethodsConsecutive ELVO patients treated with MT during a 4-year period in a tertiary stroke center were evaluated. The following outcomes were documented using standard definitions: symptomatic intracranial hemorrhage (sICH), successful recanalization (SR; modified TICI score 2b/3), mortality, and functional independence (modified Rankin Scale scores of 0–2).ResultsThe study population included 217 patients with ELVO (mean age 62±14 years, 50% men, median NIH Stroke Scale score 16). APT pretreatment was documented in 71 cases (33%). Patients with APT pretreatment had higher SR rates (77% vs 61%; P=0.013). The two groups did not differ in terms of sICH (6% vs 7%), 3-month mortality (25% vs 26%), and 3-month functional independence (50% vs 48%). Pretreatment with APT was independently associated with increased likelihood of SR (OR 2.18, 95% CI1.01 to 4.73; P=0.048) on multivariable logistic regression models adjusting for potential confounders. A significant interaction (P=0.014) of intravenous thrombolysis (IVT) pretreatment on the association of pre-hospital antiplatelet use with SR was detected. APT pretreatment was associated with SR (OR 2.74, 95% CI 1.15 to 6.54; P=0.024) in patients treated with combination therapy (IVT and MT) but not in those treated with direct MT (OR 1.78, 95% CI 0.63 to 5.03; P=0.276).ConclusionAPT pretreatment does not increase the risk of sICH and may independently improve the odds of SR in patients with ELVO treated with MT. The former association appears to be modified by IVT.
de Sitter geodesics
Authors: Cotăescu Ion I. 
Published: December 2017

The geodesics on the (1 + 3)-dimensional de Sitter (dS) spacetime are considered studying how their parameters are determined by the conserved quantities in the conformal Euclidean, Friedmann–Lemaître–Robertson–Walker, de Sitter–Painlevé and static local charts with Cartesian space coordinates. Moreover, it is shown that there exists a special static chart in which the geodesics are genuine hyperbolas whose asymptotes are given by the conserved momentum and the associated dual momentum.
Competitive Author Profiling Using Compression-Based Strategies
Authors: Claude Francisco , Galaktionov Daniil , Konow Roberto , Ladra Susana , Pedreira Óscar 
Published: December 2017

Author profiling consists in determining some demographic attributes — such as gender, age, nationality, language, religion, and others — of an author for a given document. This task, which has applications in fields such as forensics, security, or marketing, has been approached from different areas, especially from linguistics and natural language processing, by extracting different types of features from training documents, usually content — and style-based features. In this paper we address the problem by using several compression-inspired strategies that generate different models without analyzing or extracting specific features from the textual content, making them style-oblivious approaches. We analyze the behavior of these techniques, combine them and compare them with other state-of-the-art methods. We show that they can be competitive in terms of accuracy, giving the best predictions for some domains, and they are efficient in time performance.
Remark on Algorithm 539
Authors: Hanson Richard J. , Hopkins Tim 
Published: December 2017

We propose a set of new Fortran reference implementations, based on an algorithm proposed by Kahan, for the Level 1 BLAS routines
*NRM2
that compute the Euclidean norm of a real or complex input vector. The principal advantage of these routines over the current offerings is that, rather than losing accuracy as the length of the vector increases, they generate results that are accurate to almost machine precision for vectors of length
N
<
N

max

where
N

max

depends upon the precision of the floating point arithmetic being used. In addition, we make use of intrinsic modules, introduced in the latest Fortran standards, to detect occurrences of non-finite numbers in the input data and return suitable values as well as setting IEEE floating point status flags as appropriate. A set of C interface routines is also provided to allow simple, portable access to the new routines.

To improve execution speed, we advocate a hybrid algorithm; a simple loop is used first and, only if IEEE floating point exception flags signal, do we fall back on Kahan’s algorithm. Since most input vectors are “easy,” i.e., they do not require the sophistication of Kahan’s algorithm, the simple loop improves performance while the use of compensated summation ensures high accuracy.
We also report on a comprehensive suite of test problems that has been developed to test both our new implementation and existing codes for both accuracy and the appropriate settings of the IEEE arithmetic status flags.
HAShCache
Authors: Patil Adarsh , Govindarajan Ramaswamy 
Published: December 2017

Integrated Heterogeneous System (IHS) processors pack throughput-oriented General-Purpose Graphics Pprocessing Units (GPGPUs) alongside latency-oriented Central Processing Units (CPUs) on the same die sharing certain resources, e.g., shared last-level cache, Network-on-Chip (NoC), and the main memory. The demands for memory accesses and other shared resources from GPU cores can exceed that of CPU cores by two to three orders of magnitude. This disparity poses significant problems in exploiting the full potential of these architectures.
In this article, we propose adding a large-capacity stacked DRAM, used as a shared last-level cache, for the IHS processors. However, adding the DRAMCache naively, leaves significant performance on the table due to the disparate demands from CPU and GPU cores for DRAMCache and memory accesses. In particular, the imbalance can significantly reduce the performance benefits that the CPU cores would have otherwise enjoyed with the introduction of the DRAMCache, necessitating a heterogeneity-aware management of this shared resource for improved performance.

In this article, we propose three simple techniques to enhance the performance of CPU application while ensuring very little to no performance impact to the GPU. Specifically, we propose (i)
PrIS
, a prioritization scheme for scheduling CPU requests at the DRAMCache controller; (ii)
ByE
, a selective and temporal bypassing scheme for CPU requests at the DRAMCache; and (iii)
Chaining
, an occupancy controlling mechanism for GPU lines in the DRAMCache through pseudo-associativity. The resulting cache, Heterogeneity-Aware Shared DRAMCache (HAShCache), is heterogeneity-aware and can adapt dynamically to address the inherent disparity of demands in an IHS architecture. Experimental evaluation of the proposed HAShCache results in an average system performance improvement of 41% over a naive DRAMCache and over 200% improvement over a baseline system with no stacked DRAMCache.
Urinary Concentrations of Polycyclic Aromatic Hydrocarbon Metabolites in Maté Drinkers in Rio Grande do Sul, Brazil
Authors: Lopes Antonio Barros , Metzdorf Marcela , Metzdorf Luiza , Sousa Marcos Paulo Ramalho , Kavalco Caroline , Etemadi Arash , Pritchett Natalie R. , Murphy Gwen , Calafat Antonia M. , Abnet Christian C. , Dawsey Sanford M. , Fagundes Renato Borges 
Published: December 2017

Abstract
Background: Consumption of maté, an infusion of the herb Ilex paraguariensis (yerba maté), is associated with increased risk of esophageal squamous cell carcinoma (ESCC), but the carcinogenic mechanism is unclear. Commercial brands of yerba maté contain high levels of carcinogenic polycyclic aromatic hydrocarbons (PAHs), which are acquired during the traditional drying process. The purpose of this study was to characterize exposure to PAHs in maté drinkers over a wide range of maté consumption.
Methods: We recruited 244 adults who answered a questionnaire and collected a fasting spot urine specimen. We quantified urinary concentrations of seven PAH metabolites and assessed associations between self-reported recent maté consumption and urinary PAH metabolites by multivariate regression.
Results: Recent maté consumption showed a significant dose–response association with 6 of 7 PAH metabolites in unadjusted models (Ptrend &lt; 0.05). After adjustment for creatinine and potential confounders, concentrations of 2-naphthol, 1-hydroxyphenanthrene, and the sum of 2- and 3-hydroxyphenanthrene remained significantly associated with recent maté intake. The sum of the urinary concentrations of the phenanthrene metabolites was similar or higher among maté drinkers who did not smoke than among smokers who did not drink maté.
Conclusions: Urinary concentrations of PAH metabolites were significantly associated with self-reported amounts of recent maté intake, and drinking maté increased urinary concentrations of some PAH metabolites as much as smoking cigarettes.
Impact: Drinking maté is a source of exposure to potentially carcinogenic PAHs, consistent with the hypothesis that the PAH content of maté may contribute to the increased risk of ESCC in maté drinkers. Cancer Epidemiol Biomarkers Prev; 27(3); 331–7. ©2017 AACR.
Loss-of-Function Mutations in Calcitonin Receptor (CALCR) Identify Highly Aggressive Glioblastoma with Poor Outcome
Authors: Pal Jagriti , Patil Vikas , Kumar Anupam , Kaur Kavneet , Sarkar Chitra , Somasundaram Kumaravel 
Published: December 2017

Abstract
Purpose: Despite significant advances in the understanding of the biology, the prognosis of glioblastoma (GBM) remains dismal. The objective was to carry out whole-exome sequencing (WES) of Indian glioma and integrate with that of TCGA to find clinically relevant mutated pathways.
Experimental Design: WES of different astrocytoma samples (n = 42; Indian cohort) was carried out and compared with that of TCGA cohort. An integrated analysis of mutated genes from Indian and TCGA cohorts was carried out to identify survival association of pathways with genetic alterations. Patient-derived glioma stem-like cells, glioma cell lines, and mouse xenograft models were used for functional characterization of calcitonin receptor (CALCR) and establish it as a therapeutic target.
Results: A similar mutation spectrum between the Indian cohort and TCGA cohort was demonstrated. An integrated analysis identified GBMs with defective “neuroactive ligand–receptor interaction” pathway (n = 23; 9.54%) that have significantly poor prognosis (P &lt; 0.0001). Furthermore, GBMs with mutated calcitonin receptor (CALCR) or reduced transcript levels predicted poor prognosis. Exogenously added calcitonin (CT) inhibited various properties of glioma cells and pro-oncogenic signaling pathways in a CALCR-dependent manner. Patient-derived mutations in CALCR abolished these functions with the degree of loss of function negatively correlating with patient survival. WT CALCR, but not the mutant versions, inhibited Ras-mediated transformation of immortalized astrocytes in vitro. Furthermore, calcitonin inhibited patient-derived neurosphere growth and in vivo glioma tumor growth in a mouse model.
Conclusions: We demonstrate CT–CALCR signaling axis is an important tumor suppressor pathway in glioma and establish CALCR as a novel therapeutic target for GBM. Clin Cancer Res; 24(6); 1448–58. ©2017 AACR.
Investigation of the Filamin A–Dependent Mechanisms of Tissue Factor Incorporation into Microvesicles
Authors: Collier Mary , Ettelaie Camille , Goult Benjamin , Maraveyas Anthony , Goodall Alison 
Published: December 2017

AbstractWe have previously shown that phosphorylation of tissue factor (TF) at Ser253 increases the incorporation of TF into microvesicles (MVs) following protease-activated receptor 2 (PAR2) activation through a process involving filamin A, whereas phosphorylation of TF at Ser258 suppresses this process. Here, we examined the contribution of the individual phosphorylation of these serine residues to the interaction between filamin A and TF, and further examined how filamin A regulates the incorporation of TF into MVs. In vitro binding assays using recombinant filamin A C-terminal repeats 22–24 with biotinylated phospho-TF cytoplasmic domain peptides as bait showed that filamin A had the highest binding affinities for phospho-Ser253 and double-phosphorylated TF peptides, while the phospho-Ser258 TF peptide had the lowest affinity. Analysis of MDA-MB-231 cells using an in situ proximity ligation assay revealed increased proximity between the C-terminus of filamin A and TF following PAR2 activation, which was concurrent with Ser253 phosphorylation and TF-positive MV release from these cells. Knock-down of filamin A expression suppressed PAR2-mediated increases in cell surface TF procoagulant activity without reducing cell surface TF antigen expression. Disrupting lipid rafts by pre-incubation with methyl-β-cyclodextrin prior to PAR2 activation reduced TF-positive MV release and cell surface TF procoagulant activity to the same extent as filamin A knock-down. In conclusion, this study shows that the interaction between TF and filamin A is dependent on the differential phosphorylation of Ser253 and Ser258. Furthermore, the interaction of TF with filamin A may translocate cell surface TF to cholesterol-rich lipid rafts, increasing cell surface TF activity as well as TF incorporation and release into MVs.
Acute Haemarthrosis in the Haemophilia A Rat Generates a Local and Systemic Proinflammatory Response
Authors: Lövgren Karin , Christensen Kristine , Majewski Wiktor , Østrup Olga , Skov Søren , Wiinberg Bo 
Published: December 2017

Background Replacement therapy with coagulation factor VIII (FVIII) concurrent with bleeds (on-demand) in haemophilia A (HA) patients has been hypothesized to increase the risk for antidrug antibodies (inhibitors). A danger signal environment, characterized by tissue damage and inflammation at the site of a bleed, is thought to contribute to the anti-FVIII response. The nature of this inflammatory reaction is, however, not fully known, and new insights will be valuable for both managing inhibitors and understanding arthropathy development.
Objective To characterize the inflammatory response, locally and systemically, during the first 24 hours following a joint bleed in the HA rat.
Methods HA rats received a needle-induced knee joint bleed (n = 83) or a sham procedure (n = 41). Blood samples were collected at selected time points from 0 to 24 hours post injury/sham. Synovial fluid, intra-articular knee tissue and popliteal lymph nodes were collected at 24 hours. Cytokine/chemokine concentrations and gene expression were measured.
Results Gene expression analysis revealed a rapid inflammatory response in the injured knees, accompanied by significantly increased levels of specific gene products in the synovial fluid; IL-1β, TNFα, KC/GRO, IL-6, Eotaxin, MCP-1, MCP-3, MIP-1α, MIP-2, RANTES, A2M and AGP. Plasma analysis demonstrated significantly increased systemic levels of KC/GRO and IL-6 in injured rats already after 5 to 6 hours.
Conclusion A rapid proinflammatory response, locally and systemically, characteristic of innate immunity, was demonstrated. Results reveal a more comprehensive inflammatory picture than previously shown, with resemblance to human haemophilic arthropathy, and with unique correlation between gene expression level, synovial concentration and plasma concentration in individual rats.
Serum Levels of Anti-PON1 and Anti-HDL Antibodies as Potential Biomarkers of Premature Atherosclerosis in Systemic Lupus Erythematosus
Authors: López Patricia , Rodríguez-Carrio Javier , Martínez-Zapico Aleida , Pérez-Álvarez Ángel , López-Mejías Raquel , Benavente Lorena , Mozo Lourdes , Caminal-Montero Luis , González-Gay Miguel , Suárez Ana 
Published: December 2017

AbstractThe present study aimed to evaluate the possible role of immunoglobulin G (IgG) antibodies against high-density lipoproteins (HDL) and paraoxonase 1 (PON1) as possible biomarkers of cardiovascular disease (CVD) in systemic lupus erythematosus (SLE). To this end, levels of these autoantibodies, PON1 activity and total antioxidant capacity were quantified in serum samples from 198 SLE patients, 100 healthy controls (HC) and 42 non-autoimmune individuals with traditional cardiovascular risk factors. PON1 rs662 polymorphism was analysed in a subgroup of patients and controls. Subclinical CVD were determined by Doppler ultrasound in 118 SLE patients and 30 HC, analysing carotid intima-media thickness (IMT) and blood flow parameters in internal carotid, middle cerebral and basilar arteries. Serum levels of both anti-HDL and anti-PON1 antibodies were increased in SLE patients compared with HC (p < 0.001); however, only anti-PON1 antibodies, in addition to disease activity, were significant predictors of the impaired PON1 function in SLE (β  = −0.143, p = 0.045). Conversely, anti-HDL antibodies were associated with higher risk of CVD (odds ratio: 3.69; p = 0.012) and lower HDL levels at disease onset (ρ = −0.324, p = 0.044). Finally, anti-PON1 antibodies were associated with carotid IMT in SLE (β = 0.201, p = 0.008) and inversely related to cranial arteries blood flow velocities in patients with clinical and subclinical CVD (all p < 0.001). In sum, these findings allowed us to propose serum levels of anti-PON1 and anti-HDL antibodies as potential early biomarkers of endothelial damage and premature atherosclerosis in SLE, thus constituting useful therapeutic targets for the prevention of future CVD in these patients.
Benefit of Adding Ezetimibe to Statin Therapy on Cardiovascular Outcomes and Safety in Patients With Versus Without Diabetes Mellitus
Authors: Giugliano Robert P. , Cannon Christopher P. , Blazing Michael A. , Nicolau José C. , Corbalán Ramón , Špinar Jindřich , Park Jeong-Gun , White Jennifer A. , Bohula Erin A. , Braunwald Eugene 
Published: December 2017

Background:
Ezetimibe, when added to simvastatin, reduces cardiovascular events after acute coronary syndrome. We explored outcomes stratified by diabetes mellitus (DM).

Methods:
In IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial), 18 144 patients after acute coronary syndrome with low-density lipoprotein cholesterol 50 to 125 mg/dL were randomized to 40 mg ezetimibe/simvastatin (E/S) or 40 mg placebo/simvastatin. The primary composite end point was cardiovascular death, major coronary events, and stroke. DM was a prespecified subgroup.

Results:

The 4933 (27%) patients with DM were more often older and female, had had a prior myocardial infarction and revascularization, and presented more frequently with non-ST segment elevation acute coronary syndrome compared with patients without DM (each
P
<0.001). The median admission low-density lipoprotein cholesterol was lower among patients with DM (89 versus 97 mg/dL,
P
<0.001). E/S achieved a significantly lower median time-weighted average low-density lipoprotein cholesterol compared with placebo/simvastatin, irrespective of DM (DM: 49 versus 67 mg/dL; no DM: 55 versus 71 mg/dL; both
P
<0.001). In patients with DM, E/S reduced the 7-year Kaplan–Meier primary end point event rate by 5.5% absolute (hazard ratio, 0.85; 95% confidence interval, 0.78-0.94); in patients without DM, the absolute difference was 0.7% (hazard ratio, 0.98; 95% confidence interval, 0.91–1.04;
P
int
=0.02). The largest relative reductions in patients with DM were in myocardial infarction (24%) and ischemic stroke (39%). No differences in safety outcomes by treatment were present regardless of DM. When stratified further by age, patients ≥75 years of age had a 20% relative reduction in the primary end point regardless of DM (
P
int
=0.91), whereas patients <75 years of age with DM had greater benefit than those without (
P
int
=0.011). When stratified by the TIMI (Thrombolysis in Myocardial Infarction) Risk Score for Secondary Prevention, all patients with DM demonstrated benefit with E/S regardless of risk. In contrast, among patients without DM, those with a high risk score experienced a significant (18%) relative reduction in the composite of cardiovascular death, myocardial infarction, and ischemic stroke with E/S compared with placebo/simvastatin, whereas patients without DM at low or moderate risk demonstrated no benefit with the addition of ezetimibe to simvastatin (
P
int
=0.034).

Conclusions:
In IMPROVE-IT, the benefit of adding ezetimibe to statin was enhanced in patients with DM and in high-risk patients without DM.

Clinical Trial Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT00202878.
Reformational Ressourcement?
Authors: Drake K.J. 
Published: December 2017

Scholars have recognized T.F. Torrance as a ressourcement thinker in his later work while overlooking his earlier historical studies. In this article, I argue that in Calvin’s Doctrine of Man (1949) Torrance presents a rereading of Calvin in order to advance contemporary theological understanding and facilitate the reception of Karl Barth in postwar Scotland. In that work, Torrance attempts to resolve the debate between Brunner and Barth over natural theology by reinterpreting Calvin’s anthropology. Torrance accounts for Brunner’s claims regarding Calvin’s complex use and understanding of the imago dei while ultimately affirming Barth’s rejection of natural theology.
Whither the 100th Meridian? The Once and Future Physical and Human Geography of America’s Arid–Humid Divide. Part I: The Story So Far
Authors: Seager Richard , Lis Nathan , Feldman Jamie , Ting Mingfang , Williams A. Park , Nakamura Jennifer , Liu Haibo , Henderson Naomi 
Published: December 2017

Abstract
John Wesley Powell, in the nineteenth century, introduced the notion that the 100th meridian divides the North American continent into arid western regions and humid eastern regions. This concept remains firmly fixed in the national imagination. It is reexamined in terms of climate, hydrology, vegetation, land use, settlement, and the agricultural economy. It is shown there is a stark east–west gradient in aridity roughly at the 100th meridian that is well expressed in hydroclimate, soil moisture, and “potential vegetation.” The gradient arises from atmospheric circulations and moisture transports. In winter, the arid regions west of the 100th meridian are shielded from Pacific storm-related precipitation and are too far west to benefit from Atlantic storms. In summer, the southerly flow on the western flank of the North Atlantic subtropical high has a westerly component over the western plains, bringing air from the interior southwest, but it also brings air from the Gulf of Mexico over the eastern plains, generating a west–east moisture transport and precipitation gradient. The aridity gradient is realized in soil moisture and a west-to-east transition from shortgrass to tallgrass prairie. The gradient is sharp in terms of greater fractional coverage of developed land east of the 100th meridian than to the west. Farms are fewer but larger west of the meridian, reflective of lower land productivity. Wheat and corn cultivation preferentially occur west and east of the 100th meridian, respectively. The 100th meridian is a very real arid–humid divide in the physical climate and landscape, and this has exerted a powerful influence on human settlement and agricultural development.