bluuebunny/crossref_metadata_2025_split huggingface dataset:
On local domain symmetry for model expansion
Authors: DEVRIENDT JO , BOGAERTS BART , BRUYNOOGHE MAURICE , DENECKER MARC 
Published: October 2016

AbstractSymmetry in combinatorial problems is an extensively studied topic. We continue this research in the context of model expansion problems, with the aim of automating the workflow of detecting and breaking symmetry. We focus onlocal domain symmetry, which is induced by permutations of domain elements, and which can be detected on a first-order level. As such, our work is a continuation of the symmetry exploitation techniques of model generation systems, while it differs from more recent symmetry breaking techniques in answer set programming which detect symmetry on ground programs. Our main contributions are sufficient conditions for symmetry of model expansion problems, the identification oflocal domain interchangeability, which can often be broken completely, and efficient symmetry detection algorithms for both local domain interchangeability as well as local domain symmetry in general. Our approach is implemented in the model expansion system IDP, and we present experimental results showcasing the strong and weak points of our approach compared tosbass, a symmetry breaking technique for answer set programming.
The challenge of training supervisors to use direct assessments of clinical competence in CBT consistently: a systematic review and exploratory training study
Authors: Loades Maria E. , Armstrong Peter 
Published: October 2016

AbstractEvaluating and enhancing supervisee competence is a key function of supervision and can be aided by the use of direct assessments of clinical competence, e.g. the Cognitive Therapy Scale – Revised (CTS-R). We aimed to review the literature regarding inter-rater reliability and training on the CTS and CTS-R to present exploratory data on training raters to use this measure. We employed a systematic review. An exploratory study evaluated the outcomes of a CTS-R supervisor training workshop (n = 34), including self-reported familiarity with and confidence in using the tool, and inter-rater consistency on three CTS-R subscales, pre- and post-training. CTS and CTS-R inter-rater reliability was variable, with evidence of rater training enhancing reliability, although the form, duration and frequency of such training is unclear. The exploratory study found that supervisors rated themselves as more familiar with and confident in using the CTS-R at the end of training compared to at the beginning. However, inter-rater reliability was poor at the beginning and end of the training. Rating competence requires supervisors to make qualitative judgements, which is inherently variable. Training raters has been shown to improve rater reliability, although this was not demonstrated in the exploratory study. Practice implications and future research priorities are identified.
Supporting the supervisor: organizing professional development to enhance practice
Authors: Corrie Sarah , Lane David A. 
Published: October 2016

AbstractAlthough clinical supervision is deemed central to the delivery and dissemination of high quality CBT, knowledge of what constitutes ‘optimal’ CBT supervision remains limited. In consequence, understanding of how best to support the development of supervisors is also restricted. This article considers the professional development needs of CBT supervisors, identifying the current context in which CBT supervision is mandated and delivered and seeking to clarify the domains of knowledge, competence and skill that must be mastered. We propose ways in which CBT supervisors might construct their professional development activities and raise questions relating to the need for a more organizationally embedded approach to the development of CBT supervisors in the current professional climate.
Supporting our supervisors: sending out an SOS
Authors: Milne Derek L. , Reiser Robert 
Published: October 2016

AbstractIn this Introduction to the Special Issue ofthe Cognitive Behaviour Therapiston clinical supervision we start by highlighting the unmet and overdue need for coherent organizational systems to support, guide and develop clinical supervisors. We identify a seven-step, cyclical model that describes how such a system might work, with particular reference to CBT supervision. These steps start with conceptualization (e.g. definition of CBT supervision) and complete the problem-solving cycle with evaluation (e.g. corrective feedback). We provide an overview of typical research and development activity for each part of this model to illustrate how a sound supervision infrastructure might best be developed. The SOS model provides a systematic approach to indicate the organizational conditions under which CBT supervision might flourish.
Technology for evidence-based cognitive behavioural supervision: new applications and research to improve organizational support
Authors: Rousmaniere Tony 
Published: October 2016

AbstractThere has recently been an increasing call for new research and development in cognitive behavioural supervision, particularly in the area of evidence-based clinical supervision. New developments in supervision technology offer the potential to answer this call by providing greater objective measurement and corrective feedback in supervision. In this article, two new technologies that hold particular promise in this area are described: software for routine outcome measurement and videoconference for internet-based live one-way-mirror supervision. Notable challenges involved in supervision technology are discussed, and an example of technology being integrated into a graduate clinical training programme is described.
Supporting our supervisors: a Summary and Discussion of the Special Issue on CBT supervision
Authors: Newman Cory F. , Reiser Robert P. , Milne Derek L. 
Published: October 2016

AbstractContributors to this Special Issue of the Cognitive Behaviour Therapist have considered the kind of infrastructure that should be in place to best support and guide CBT supervisors, providing practical advice and extensive procedural guidance. Here we briefly summarize and discuss in turn the 10 papers within this Special Issue, including suggestions for further enhancements. The first paper, by Milne and Reiser, conceptualized this infrastructure in terms of an ‘SOS’ (supporting our supervisors) framework, from identifying supervision competencies, to training, evaluation and feedback strategies. The next nine papers illustrate this framework with specific technical innovations, educational enhancements and procedural issues, or through comprehensive quality improvement systems, all designed to support supervisors. These papers suggest an assortment of workable infrastructure developments: two large-scale and comprehensive initiatives, some promising proposals and technologies, and a series of local, exploratory work. Collectively, they provide us with models for further developing evidence-based cognitive-behavioural supervision, and offer practical suggestions for giving supervisors the tools and support to maximize their supervisees’ learning, and to improve the associated client outcomes. Much research and development work remains to be done, and successful implementation will require institutional and political support, as well as cross-cultural adaptations. We conclude with an optimistic assessment of progress toward addressing some of the infrastructure improvements required to adequately support supervisors.
Adaptation, Validation, Reliability and Factorial Equivalence of the Rosenberg Self-Esteem Scale in Colombian and Spanish Population
Authors: Gómez-Lugo Mayra , Espada José P. , Morales Alexandra , Marchal-Bertrand Laurent , Soler Franklin , Vallejo-Medina Pablo 
Published: October 2016

AbstractThe Rosenberg Self-Esteem Scale is the most widely used instrument to assess self-esteem. In light of the absence of adaptations in Colombia, this study seeks to validate and adapt this scale in the Colombian population, and perform factorial equivalence with the Spanish version. A total of 1,139 seniors (633 Colombians and 506 Spaniards) were evaluated; the individuals answered the Rosenberg Self-Esteem Scale and sexual self-esteem scale. The average score of the items was similar to the questionnaire’s theoretical average, and standard deviations were close to one. The psychometric properties of the items are generally adequate with alphas of .83 and .86 and significant (CI = .95) and correlations with the sexual self-esteem scale ranging from .31 and .41. Factorial equivalence was confirmed by means of a structural equation model (CFI = .912 and RMSEA = .079), thus showing a strong level of invariance.
Neural tube morphogenesis in synthetic 3D microenvironments
Authors: Ranga Adrian , Girgin Mehmet , Meinhardt Andrea , Eberle Dominic , Caiazzo Massimiliano , Tanaka Elly M. , Lutolf Matthias P. 
Published: October 2016

Significance
In vitro organoids have become widely used model systems in basic research and for therapeutic applications due to their ability to recapitulate key elements of in vivo form and function. However, their full potential remains unfulfilled as a result of the poorly defined matrices in which they are grown. Here, we use modular synthetic 3D matrices to show that early neural morphogenesis can be precisely controlled by the extracellular microenvironment. Our approach is broadly applicable to gain a broader understanding of the multifactorial 3D cell–matrix interactions that coordinate multicellular growth and differentiation, and opens up avenues to discover and dissect the unique microenvironments that control morphogenesis in various organoid systems.
Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy
Authors: Kuzmanov Uros , Guo Hongbo , Buchsbaum Diana , Cosme Jake , Abbasi Cynthia , Isserlin Ruth , Sharma Parveen , Gramolini Anthony O. , Emili Andrew 
Published: October 2016

Significance
The present study demonstrates the utility of global phosphoproteomic profiling of diseased cardiac tissue to identify signaling pathways and other biological processes disrupted in cardiomyopathy. Perturbed Notch-1 signaling was identified by bioinformatics analyses of phosphoprotein patterns present in affected cardiac tissue in a transgenic mouse model system of dilated cardiomyopathy and by complementary molecular biology and microscopy techniques. In addition, dozens of other disturbed signaling pathways offer an opportunity for novel therapeutic and/or diagnostic clinically applicable targets. Although this study was performed in mice, only minor adjustments to the experimental approach would be required for comparative analysis of analogous samples from human cardiac patients, potentially leading to even more clinically relevant data.
Matrix mechanics controls FHL2 movement to the nucleus to activate p21 expression
Authors: Nakazawa Naotaka , Sathe Aneesh R. , Shivashankar G. V. , Sheetz Michael P. 
Published: October 2016

Significance
Substrate rigidity has important roles for physiological processes, such as stem cell differentiation and cell growth. Although substrate rigidity clearly modulates gene expression, the mechanism of rigidity control of gene expression remains unknown. Our work reveals that four-and-a-half LIM domains (domain discovered in the proteins, Lin11, Isl-1, and Mec-3) 2 moves from adhesion sites to the nucleus on soft substrates through focal adhesion kinase activity and up-regulates p21 gene expression. Thus, we show a molecular pathway for inhibiting cell growth on soft substrates.
Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children
Authors: Lewinsohn David M. , Leonard Michael K. , LoBue Philip A. , Cohn David L. , Daley Charles L. , Desmond Ed , Keane Joseph , Lewinsohn Deborah A. , Loeffler Ann M. , Mazurek Gerald H. , O’Brien Richard J. , Pai Madhukar , Richeldi Luca , Salfinger Max , Shinnick Thomas M. , Sterling Timothy R. , Warshauer David M. , Woods Gail L. 
Published: October 2016

AbstractBackground.Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms and signs of disease (tuberculosis disease) or may have no clinical evidence of disease (latent tuberculosis infection [LTBI]). Tuberculosis disease is a leading cause of infectious disease morbidity and mortality worldwide, yet many questions related to its diagnosis remain.Methods.A task force supported by the American Thoracic Society, Centers for Disease Control and Prevention, and Infectious Diseases Society of America searched, selected, and synthesized relevant evidence. The evidence was then used as the basis for recommendations about the diagnosis of tuberculosis disease and LTBI in adults and children. The recommendations were formulated, written, and graded using the Grading, Recommendations, Assessment, Development and Evaluation (GRADE) approach.Results.Twenty-three evidence-based recommendations about diagnostic testing for latent tuberculosis infection, pulmonary tuberculosis, and extrapulmonary tuberculosis are provided. Six of the recommendations are strong, whereas the remaining 17 are conditional.Conclusions.These guidelines are not intended to impose a standard of care. They provide the basis for rational decisions in the diagnosis of tuberculosis in the context of the existing evidence. No guidelines can take into account all of the often compelling unique individual clinical circumstances.
Predictive factors of uterine movement during definitive radiotherapy for cervical cancer
Authors: Maemoto Hitoshi , Toita Takafumi , Ariga Takuro , Heianna Joichi , Yamashiro Tsuneo , Murayama Sadayuki 
Published: October 2016

Abstract
To determine the predictive factors affecting uterine movement during radiotherapy (RT), we quantified interfraction uterine movement using computed tomography (CT) and cone-beam CT (CBCT). A total of 38 patients who underwent definitive RT for cervical cancer were retrospectively analyzed. We compared pre-RT planning CT (n = 38) and intratreatment CBCT (n = 315), measuring cervical and corporal movement in each direction. Correlations between uterine movement and volume changes of the bladder and rectum on all CBCT scans were analyzed using Spearman rank correlation analysis. Relationships between the mean uterine movement and patient factors were analyzed using the Mann–Whitney test. The mean corpus movement was: superior margin (cranio–caudal direction), 7.6 ± 5.9 mm; anterior margin (anteroposterior direction), 8.3 ± 6.3 mm; left margin (lateral direction), 3.3 ± 2.9 mm; and right margin (lateral direction), 3.0 ± 2.3 mm. Generally, the mean values for cervical movement were smaller than those for the corpus. There was a significant, weak correlation between changes in bladder volume and the movement of the superior margin of the corpus (ρ = 0.364, P &lt; 0.001). There was a significant difference in movement of the superior margin of the corpus between the subgroups with and without a history of previous pelvic surgery (P = 0.007). In conclusion, change in bladder volume and a history of previous surgery were significantly related to intrafractional corpus movement; however, our observations suggest that the accurate prediction of uterine movement remains challenging.
Epigenetic regulation and epigenomic landscape in rice
Authors: Deng Xian , Song Xianwei , Wei Liya , Liu Chunyan , Cao Xiaofeng 
Published: October 2016

AbstractEpigenetic regulation has been implicated in the control of complex agronomic traits in rice (Oryza sativa), a staple food crop and model monocot plant. Recent advances in high-throughput sequencing and the moderately complex genome of rice have made it possible to study epigenetic regulation in rice on a genome-wide scale. This review discusses recent advances in our understanding of epigenetic regulation in rice, with an emphasis on the roles of key epigenetic regulators, the epigenomic landscape, epigenetic variation, transposon repression, and plant development.
Research, rethink and revolutionize rice breeding: an interview with Qifa Zhang
Authors: Ma Zisong 
Published: October 2016

Abstract
More than 100 Nobel laureates recently signed a letter urging Greenpeace to end its opposition to genetically modified organisms (GMOs). With an ever-increasing demand for food, China finds itself confronted with the same question: is it time to rethink and reassess its stance towards GMO? Rice is one of the most important food crops in China and around the world. In recent years, Chinese scientists have made important progress in rice functional genomics research including identifying genes and regulatory mechanisms and platforms and technologies for breeding new varieties. However, in contrast to the progress in scientific research, the commercial, social and policy framework remains largely unresolved. National Science Review (NSR) spoke with Qifa Zhang (Zhang), Professor at Huazhong Agricultural University, Academician of the Chinese Academy of Sciences and Foreign Associate of National Academy of Sciences, USA. In this interview, Prof. Zhang shares with us his views and insights on the frontier research in rice studies and commercialization of transgenic rice in China.
Rapid Occurrence of Chronic Kidney Disease in Patients Experiencing Reversible Acute Kidney Injury after Cardiac Surgery
Authors: Legouis David , Galichon Pierre , Bataille Aurélien , Chevret Sylvie , Provenchère Sophie , Boutten Anne , Buklas Dimitrios , Fellahi Jean-Luc , Hanouz Jean-Luc , Hertig Alexandre 
Published: October 2016

Abstract

Background
There is recent evidence to show that patients suffering from acute kidney injury are at increased risk of developing chronic kidney disease despite the fact that surviving tubular epithelial cells have the capacity to fully regenerate renal tubules and restore renal function within days or weeks. The aim of the study was to investigate the impact of acute kidney injury on de novo chronic kidney disease.

Methods
The authors conducted a retrospective population-based cohort study of patients initially free from chronic kidney disease who were scheduled for elective cardiac surgery with cardiopulmonary bypass and who developed an episode of acute kidney injury from which they recovered. The study was conducted at two French university hospitals between 2005 and 2015. These individuals were matched with patients without acute kidney injury according to a propensity score for developing acute kidney injury.

Results
Among the 4,791 patients meeting the authors’ inclusion criteria, 1,375 (29%) developed acute kidney injury and 685 fully recovered. Propensity score matching was used to balance the distribution of covariates between acute kidney injury and non- acute kidney injury control patients. Matching was possible for 597 cases. During follow-up, 34 (5.7%) had reached a diagnosis of chronic kidney disease as opposed to 17 (2.8%) in the control population (hazard ratio, 2.3; bootstrapping 95% CI, 1.9 to 2.6).

Conclusions
The authors’ data consolidate the recent paradigm shift, reporting acute kidney injury as a strong risk factor for the rapid development of chronic kidney disease.
The ConNECtion Between Abdominal Signs and Necrotizing Enterocolitis in Infants 501 to 1500 g
Authors: Gephart Sheila M. , Fleiner Michelle , Kijewski Amy 
Published: October 2016

Background:
Necrotizing enterocolitis (NEC) can become severe quickly, making early recognition a priority and understanding the occurrence of abdominal and clinical signs of impending NEC important.

Purpose:
The purpose of this study was to examine relationships of abdominal signs up to 36 hours before diagnosis of NEC within subgroups treated medically, surgically, or those who died.

Methods:
A 3-site, descriptive correlational case-control design with retrospective data collection was used matching each NEC case to 2 controls (N = 132).

Results:
NEC cases were exposed to less human milk and fed later. Among them, 61% (n = 27) had at least 1 abdominal sign 36 hours before diagnosis, with fewer numbers having 2 (18%; n = 8) or 3 (5%; n = 2). At 36 hours before NEC, abdominal distension, duskiness, higher gastric residual, and greater count of abdominal signs were associated with severe NEC. No medical NEC cases had abdominal signs 36 or 24 hours before diagnosis. Highest severity of NEC was related to more abdominal signs at the times leading up to and at diagnosis of NEC. Gastric residuals were largely unrelated to NEC except for the most severe NEC at 36 hours before diagnosis.

Implications for Practice:
Communicating a count of abdominal signs may support earlier recognition and treatment of NEC.

Implications for Research:
More research is needed to explore timing for clinical worsening of status (eg, surgical and NEC leading to death) and to study effective clinical approaches targeting early recognition to support timely action.
Debilitating Effects of Femoral Nonunion on Health-Related Quality of Life
Authors: Brinker Mark R. , Trivedi Akash , O'Connor Daniel P. 
Published: October 2016

Objective:
The purpose of this study was to report the extent of the effects of femoral nonunion on health-related quality of life.

Design:
Retrospective cohort.

Setting:
Tertiary referral center.

Patients/Participants:
One hundred eighty-seven consecutive patients (85 women, age 55.9 ± 16.9 years; 102 men, age 42.8 ± 16.1 years) with 188 nonunions of the femur, excluding those involving the hip or knee articular surfaces.

Intervention:
Average nonunion duration was 28.5 months. 5.7% of the nonunions were infected, and the distal third was the most frequently involved segment.

Main Outcome Measurements:
SF-12 Mental Component Summary (MCS) and Physical Component Summary (PCS) scores, Brief Pain Inventory (BPI), American Academy of Orthopaedic Surgeons Lower Limb Core Scale (LLCS), and Time Trade-Off (TTO) reported at the time of initial clinical evaluation at our center.

Results:
The MCS scores averaged 43 ± 6.5, and the PCS scores averaged 26.3 ± 6.5, indicating the large adverse impact of femoral nonunion on mental and physical health, respectively. The BPI average intensity score averaged 5.1 ± 2.5, indicating moderate to severe pain. The LLCS averaged 53.9 ± 20.0, indicating substantial lower extremity-specific disability. The TTO questionnaire responses indicated that these patients were willing to trade an average of 38.3% of their remaining years of life to regain health.

Conclusions:
The impact of femoral shaft nonunion on physical health was comparable to end-stage hip arthrosis and tibial nonunion and worse than many other medical conditions. Femoral shaft nonunion is a debilitating chronic medical condition with substantial negative effects on health.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.