bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longevity and stress resistance are affected by activation of TOR/Myc in progenitor cells of Drosophila gut
Authors: Strilbytska Olha M. , Koliada Alexander K. , Storey Kenneth B. , Mudra Olha , Vaiserman Alexander M. , Lushchak Oleh 
Published: January 2018

AbstractDiverse physiological pathways have been shown to regulate longevity, stress resistance, fecundity and feeding rates, and metabolism in Drosophila. Here we tesed physiological traits in flies with Rheb and Myc- Rheb overexpressed in gut progenitor cells, known as enteroblasts (EBs). We found that activation of TOR signaling by overexpression of Rheb in EBs decreases survival and stress resistance. Additionall, we showed that Myc co-expression in EBs reduces fly fecundity and feeding rate. Rheb overexpression enhanced the level of whole body glucose. Higher relative expression of the metabolic genes dilps, akh, tobi and pepck was, however, observed. The role of TOR/Myc in the regulation of genes involved in lipid metabolism and protein synthesis was established. We showed a significant role of TOR/Myc in EBs in the regulation of the JAK/STAT, EGFR and insulin signaling pathways in Drosophila gut. These results highlight the importance of the balance between all different types of cells and confirm previous studies demonstrating that promotion of homeostasis in the intestine of Drosophila may function as a mechanism for the extension of organismal lifespan. Overall, the results demonstrate a role of TOR signaling and its downstream target Myc in EB cells in the regulation of Drosophila physiological processes.
Sevoflurane-medicated the pathway of chemokine receptors bind chemokines in patients undergoing CABG
Authors: Kong Bing , Ma Yu-Wu , Li De-Xue , Liu Xi-Jiang , Xu Yong-Guang 
Published: January 2018

AbstractBackgroundWe aim to identify sevoflurane-induced modules and pathways in patients following coronary artery bypass graft (CABG) surgery, and to further elucidate the molecular mechanisms of the cardioprotective effects of sevoflurane.MethodsDifferential co-expression network (DCN) was constructed. Candidate modules were identified via three steps: selection of seed genes, search of modules using snowball sampling, and refinement of modules. Afterwards, the significance of the candidate modules was assessed. Ultimately, pathway analyses for genes in differential modules were implemented to illuminate the biological processes.ResultsOverall, 122 genes were identified to serve as seed genes. From every seed gene, we extracted 122 modules and the mean node size in a module was 3. By setting the classification accuracy cutoff at 0.9 and the number of nodes in a module at 5, 7 candidate modules were identified, including module 80, 82, 82, 84, 85, 86 and 89. Based on the random permutation test, we found that these 7 candidate modules were all differential ones. Moreover, pathway analysis showed that genes in the differential modules 80, 82, and 85 were all enriched in the pathway of chemokine receptors bind chemokines.ConclusionSevoflurane might exert cardioprotective functions in patients following CABG, partially through regulating the pathway of chemokine receptors bind chemokines.
Curcumin attenuates oxidative stress in liver in Type 1 diabetic rats
Authors: Xie Zhenglu , Zeng Xinqi , Li Xiaqing , Wu Binbin , Shen Guozhi , Wu Qianying , Wu Changbiao 
Published: January 2018

AbstractWe investigated the effect of curcumin on liver anti-oxidative stress in the type 1 diabetic rat model induced by streptozotocin (STZ). Experimental diabetic rats were induced by STZ intraperitoneally. All rats were fed for 21 days including three groups of control (NC), diabetic model (DC) and curcumin-treated (Cur, 1.5 g/kg by gavage). The results showed that curcumin-treatment significantly decreased the blood glucose and plasma malondialdehyde levels, but significantly increased the plasma superoxide dismutase, glutathione peroxidase and reduced glutathione levels. Curcumin treatment decreased the activity of aldose reductase, but increased the plasma glucose-6-phosphate dehydrogenase, glucose synthetase and glucose-polymerizing activities. Curcumin treatment significantly decreased the protein of protein kinase C (PKC) and poly ADP ribose polymerase (PARP) expression in the Cur group compared with the DC group. Moreover, the sorbitol dehydrogenase activity was significantly decreased and deterred glucose enters into the polyol pathway leading to an increased NADPH content in the Cur group compared with the DC group. Our data provides evidence that oxidative stress in diabetic rats may be attenuated by curcumin by inhibiting polyol pathway associated with down-regulated expression of PKC and PARP, as evidenced by both an increase the antioxidant enzymes levels and glycogen biosynthesis enzymes activities.
Research Progress on Tissue Culture and Genetic Transformation of Kenaf (Hibiscus cannabinus)
Authors: An Xia , Jin Guanrong , Zhang Jingyu , Ma GuangYing ,   LunjinDai, Jin Liang , Luo Xiahong , Chen Changli , Shi Xiaohua , Zhou Jun , Wei Wei , Li Wenlue , Chen Cong , Deng Gang , Zhu Guanlin 
Published: January 2018

AbstractRecent research progresses on tissue culture (e.g. fast reproduction, another culture, protoplast culture and organogenesis) and genetic transformation of kenaf were reviewed and summarized in this paper. Existing problems were discussed, aiming to provide scientific references for promoting tissue culture and genetic transformation of kenaf.
Classical (adiponectin, leptin, resistin) and new (chemerin, vaspin, omentin) adipocytokines in patients with prediabetes
Authors: Gateva Antoaneta , Assyov Yavor , Tsakova Adelina , Kamenov Zdravko 
Published: January 2018

Abstract

Background
In the last decade, there has been an increased interest toward fat tissue as an endocrine organ that secretes many cytokines and bioactive mediators that play a role in insulin sensitivity, inflammation, coagulation and the pathogenesis of atherosclerosis. The aim of this study was to investigate classical (adiponectin, leptin, resistin) and new (chemerin, vaspin, omentin) adipocytokine levels in subjects with prediabetes [impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT)] and obese subjects with normoglycemia.

Methods
In this study, 80 patients with a mean age of 50.4 ± 10.6 years were recruited, divided into two groups with similar age and body mass index (BMI) – with obesity and normoglycemia (n = 41) and with obesity and prediabetes (n = 39).

Results
Serum adiponectin levels were significantly higher in subjects with normoglycemia compared to patients with prediabetes. Adiponectin has a good discriminating power to distinguish between patients with and without insulin resistance in our study population [area under the curve (AUC) = 0.728, p = 0.002]. Other adipocytokine levels were not significantly different between the two groups. The patients with metabolic syndrome (MetS) had significantly lower levels of leptin compared to those without MetS (33.03 ± 14.94 vs. 40.24 ± 12.23 ng/mL) and this difference persisted after adjustment for weight and BMI. Receiver operating characteristic (ROC) analysis showed that low serum leptin can predict the presence of MetS (p = 0.03), AUC = 0.645.

Conclusion
Serum adiponectin is statistically higher in patients with normoglycemia compared to those with prediabetes and has a predictive value for distinguishing between patients with and without insulin resistance in the studied population. Serum leptin has a good predictive value for distinguishing between patients with and without MetS in the studied population.
Patterns and predictors of disclosure of HIV positive status among youth living with HIV in Ibadan, Nigeria
Authors: Olumide Adesola , Owoaje Eme 
Published: January 2018

AbstractBackgroundInformation on disclosure of HIV status among youth is sparse in spite of the fact that they bear a significant burden of the HIV epidemic. Our objective was to determine the predictors of HIV disclosure among youth aged 18–35 years in Ibadan, Nigeria.MethodsA cross-sectional study was conducted among youth with HIV attending two HIV support groups and one ARV clinic in Ibadan, Nigeria. Information was obtained with the aid of an interviewer-administered questionnaire. Descriptive and analytic statistics were conducted.ResultsThere were 170 clients with a mean age of 29.6 ± 3.9 years; 140 (82.4%) were female and 139 (81.8%) had disclosed their status. Common people first informed included respondents’ mother 49 (35.3%), spouse 39 (28.1%) or father, 38 (27.3%). Disclosure to an unmarried sexual partner was low as only six (12.0%) of the 50 single youth who had a current sexual partner had disclosed their status to him/her. Youth who were aware that their spouse/partner was HIV positive (OR = 9.87; CI = 1.09–88.83) or negative (OR = 9.98; CI = 1.18–84.70) were more likely to have disclosed their status than those unaware of their spouse/partners’ status. Disclosure was also higher among members of an HIV support group (OR = 3.32; CI = 1.03–10.72).ConclusionsMany respondents had disclosed their status although disclosure to an unmarried sexual partner was low. Interventions to improve HIV disclosure especially among unmarried sexually active youth could improve disclosure and overall management of HIV in our study area.
Influence of waist circumference on blood pressure status in non-obese adolescents
Authors: Benmohammed Karima , Valensi Paul , Nguyen Minh Tuan , Benmohammed Farah , Benlatreche Moufida , Benembarek Karima , Lezzar Alkassem 
Published: January 2018

Abstract

Objectives
To check whether excess in abdominal adiposity and metabolic factors were associated with blood pressure abnormalities in non-obese adolescents.

Methods
We randomly selected 1100 adolescent students, aged 12–18 years, from schools and classrooms in the city of Constantine, Algeria. Among them 179 were overweight and 51 were obese (IOTF criteria). Waist circumference (WC) was considered high if >74 cm in boys and 75 cm in girls (mean of WC of all population studied). Hypertension (HBP) and prehypertension (preHBP) were defined by the NHBPEP’s 2004 criteria.

Results
The prevalence of HBP/preHBP were 13.0%/12.4% with no difference between boys and girls. The percentages of HBP/preHBP patients were 15.6%/15.6% in overweight adolescents, 5.9%/31.4% in obese adolescents and 12.9%/10.6% in adolescents with normal body weight (p < 0.0001).
In obese adolescents, the prevalence of HBP was higher among boys than girls (36% vs. 27%, p = 0.002). In normal and overweight adolescents, the prevalence of HBP and preHBP was similar in boys and girls (11.9% vs. 11.0% and 14.7% vs. 12.1%); the association of WC (high vs. not high) with HBP was found in boys (16.1% vs. 8.8%, p = 0.009) but not in girls (12.1% vs. 10.2%), and with preHBP in girls (15.5% vs. 8.0%, p = 0.029) but not in boys (16.2% vs. 13.6%). Waist circumference [OR: 1.04 (1.03–1.06); p < 0.0001] and HOMA index [OR: 1.65 (1.13–2.39); p = 0.009] were associated with an increased risk of HBP.

Conclusion
In non-obese adolescents, a high WC, defined by values over the mean WC observed in our population, is associated with a higher risk of HBP in boys.
Post-traumatic stress and growth among CPR survivors in the southeast of Iran
Authors: Seyed Bagheri Seyed Hamid , Iranmanesh Sedigheh , Rayyani Masoud , Dehghan Mahlagha , Tirgari Batool , Hosseini Seyed Habibollah 
Published: January 2018

Abstract

Background
Almost 7.2%–10.6% of patients survive CPR in Iran. Most of them experience post-traumatic stress disorder (PTSD) and post-traumatic growth (PTG). There are limited studies to assessing the correlation between these two psychological outcomes among CPR survivors.

Objective
This study aimed to examine the correlation between PTSD and PTG among CPR survivors in South-East Iran.

Subjects
Using Quota sampling, 163 CPR survivors in two provinces in the South-East of Iran were selected to participate in this study.

Method
A descriptive-correlational study was used to fulfill the aim of the study. The impact of Event Scale-Revised (IES-R) for assessing PTSD and Post-traumatic growth questionnaires were used to assess PTG.

Results
The mean score of PTSD was 39.89 and according to the cutoff point, 87.1% of participants suffered from PTSD. The mean score of PTG was 78.6. PTSD and PTG had significant negative correlation. The result of multi-variate logistic regression showed that only the PTG score predicted PTSD (Odds ratio = 0.79, CI = 0.72–0.87; and p < 0.001). The result of multi-variate linear regression indicated that PTSD, time passed since CPR, and physical disability caused by CPR predicted PTG score significantly.

Conclusion
This study provides CPR survivors and health care personnel with some valuable insights about cultural aspects of PTSD and PTG among CPR survivors and that PTG is positively influenced by physical disability and time passed since CPR. CPR survivors may gain positive experience and valuable insight in group meetings and discussions with their counterparts.
Understanding Big Data for Industrial Innovation and Design: The Missing Information Systems Perspective
Authors: Nunes Miguel Baptista 
Published: January 2018

Abstract
This paper identifies a need to complement the current rich technical and mathematical research agenda on big data with a more information systems and information science strand, which focuses on the business value of big data. An agenda of research for information systems would explore motives for using big data in real organizational contexts, and consider proposed benefits, such as increased effectiveness and efficiency, production of high-quality products/services, creation of added business value, and stimulation of innovation and design. Impacts of such research on the academic community, the industrial and business world, and policy-makers are discussed.
A Framework for the Assessment of Research and Its Impacts
Authors: Daraio Cinzia 
Published: January 2018

Abstract
This paper proposes a holistic framework for the development of models for the assessment of research activities and their impacts. It distinguishes three dimensions, including in an original way, data as a main dimension, together with theory and methodology. Each dimension of the framework is further characterized by three main building blocks: education, research, and innovation (theory); efficiency, effectiveness, and impact (methodology); and availability, interoperability, and “unit-free” property (data). The different dimensions and their nine constituent building blocks are attributes of an overarching concept, denoted as “quality.” Three additional quality attributes are identified as implementation factors (tailorability, transparency, and openness) and three “enabling” conditions (convergence, mixed methods, and knowledge infrastructures) complete the framework. A framework is required to develop models of metrics. Models of metrics are necessary to assess the meaning, validity, and robustness of metrics. The proposed framework can be a useful reference for the development of the ethics of research evaluation. It can act as a common denominator for different analytical levels and relevant aspects and is able to embrace many different and heterogeneous streams of literature. Directions for future research are provided.
Rediscovering Don Swanson:The Past, Present and Future of Literature-based Discovery
Authors: Smalheiser Neil R. 
Published: January 2018

Abstract

Purpose
The late Don R. Swanson was well appreciated during his lifetime as Dean of the Graduate Library School at University of Chicago, as winner of the American Society for Information Science Award of Merit for 2000, and as author of many seminal articles. In this informal essay, I will give my personal perspective on Don’s contributions to science, and outline some current and future directions in literature-based discovery that are rooted in concepts that he developed.

Design/methodology/approach
Personal recollections and literature review.

Findings
The Swanson A-B-C model of literature-based discovery has been successfully used by laboratory investigators analyzing their findings and hypotheses. It continues to be a fertile area of research in a wide range of application areas including text mining, drug repurposing, studies of scientific innovation, knowledge discovery in databases, and bioinformatics. Recently, additional modes of discovery that do not follow the A-B-C model have also been proposed and explored (e.g. so-called storytelling, gaps, analogies, link prediction, negative consensus, outliers, and revival of neglected or discarded research questions).

Research limitations
This paper reflects the opinions of the author and is not a comprehensive nor technically based review of literature-based discovery.

Practical implications
The general scientific public is still not aware of the availability of tools for literature-based discovery. Our Arrowsmith project site maintains a suite of discovery tools that are free and open to the public (http://arrowsmith.psych.uic.edu), as does BITOLA which is maintained by Dmitar Hristovski (http://http://ibmi.mf.uni-lj.si/bitola), and Epiphanet which is maintained by Trevor Cohen (http://epiphanet.uth.tmc.edu/). Bringing user-friendly tools to the public should be a high priority, since even more than advancing basic research in informatics, it is vital that we ensure that scientists actually use discovery tools and that these are actually able to help them make experimental discoveries in the lab and in the clinic.

Originality/value
This paper discusses problems and issues which were inherent in Don’s thoughts during his life, including those which have not yet been fully taken up and studied systematically.
An Accurate and Impartial Expert Assignment Method for Scientific Project Review
Authors: Yue Mingliang , Tian Kailin , Ma Tingcan 
Published: January 2018

Abstract

Purpose
This paper proposes an expert assignment method for scientific project review that considers both accuracy and impartiality. As impartial and accurate peer review is extremely important to ensure the quality and feasibility of scientific projects, enhanced methods for managing the process are needed.

Design/methodology/approach
To ensure both accuracy and impartiality, we design four criteria, the reviewers’ fitness degree, research intensity, academic association, and potential conflict of interest, to express the characteristics of an appropriate peer review expert. We first formalize the expert assignment problem as an optimization problem based on the designed criteria, and then propose a randomized algorithm to solve the expert assignment problem of identifying reviewer adequacy.

Findings
Simulation results show that the proposed method is quite accurate and impartial during expert assignment.

Research limitations
Although the criteria used in this paper can properly show the characteristics of a good and appropriate peer review expert, more criteria/conditions can be included in the proposed scheme to further enhance accuracy and impartiality of the expert assignment.

Practical implications
The proposed method can help project funding agencies (e.g. the National Natural Science Foundation of China) find better experts for project peer review.

Originality/value
To the authors’ knowledge, this is the first publication that proposes an algorithm that applies an impartial approach to the project review expert assignment process. The simulation results show the effectiveness of the proposed method.
Using Machine Reading to Understand Alzheimer’s and Related Diseases from the Literature
Authors: Tsutsui Satoshi , Bu Yi , Ding Ying 
Published: January 2018

Abstract

Purpose
This paper aims to better understand a large number of papers in the medical domain of Alzheimer’s disease (AD) and related diseases using the machine reading approach.

Design/methodology/approach
The study uses the topic modeling method to obtain an overview of the field, and employs open information extraction to further comprehend the field at a specific fact level.

Findings
Several topics within the AD research field are identified, such as the Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS), which can help answer the question of how AIDS/HIV and AD are very different yet related diseases.

Research limitations
Some manual data cleaning could improve the study, such as removing incorrect facts found by open information extraction.

Practical implications
This study uses the literature to answer specific questions on a scientific domain, which can help domain experts find interesting and meaningful relations among entities in a similar manner, such as to discover relations between AD and AIDS/HIV.

Originality/value
Both the overview and specific information from the literature are obtained using two distinct methods in a complementary manner. This combination is novel because previous work has only focused on one of them, and thus provides a better way to understand an important scientific field using data-driven methods.
All-Optical Logic Gates and Boolean Expressions in a Photonic Mach–Zehnder Interferometer
Authors: Filho G. S. B , Martins F. L. B , Junior M. F , Araújo A. A. R , Nascimento J. C , Coelho A. G , de Fraga W. B 
Published: January 2018

Abstract
In this paper, we numerically investigate the behavior of solitons in a Mach–Zehnder interferometer made of dual-core photonic crystal fibers. The goal was to obtain logic gates with modulated information in ON-OFF keying (OOK). We considered ultra-short solitonic pulses propagating throughout the system in two distinct regimes of pump power and obtained the OR and XOR gates with fundamental solitons. In addition, the A→B and A←B Boolean expressions were obtained with high peak power. As these logical expressions were obtained with the same length of the obtained logic gates, they are important and therefore can be used to save space in the design of complex circuits.
Insulin resistance and lung function in obese asthmatic pre-pubertal children
Authors: Di Filippo Paola , Scaparrotta Alessandra , Rapino Daniele , de Giorgis Tommaso , Petrosino Marianna Immacolata , Attanasi Marina , Di Pillo Sabrina , Chiarelli Francesco , Mohn Angelika 
Published: January 2018

Abstract

Background:
Recent findings have supposed that the underlying association between the increased prevalence of both asthma and obesity may be insulin resistance (IR).

Methods:
Insulin and glucose serum levels were analyzed to calculate the homeostatic model assessment of insulin resistance (HOMA-IR) for IR in 98 pre-pubertal children. Lung function and allergy status evaluation were performed. The study population was divided into four groups: (1) obese asthmatic children (ObA); (2) normal-weight asthmatic children (NwA); (3) normal-weight non-asthmatic children (Nw) and (4) obese non-asthmatic children (Ob).

Results:
Forced expiratory volume in 1 s (FEV1) was slightly lower in obese subjects compared with normal-weight subjects and forced vital capacity (FVC) appeared lower in asthmatics, whereas between non-asthmatics subjects, it was lower in the obese group than in the normal-weight one. The post hoc analysis revealed a statistically significant reduction in FEV1, peak expiratory flow (PEF), forced expiratory flows (FEF) between 50% and 25% of the FVC (FEF50 and FEF25) between ObA and Nw and in FEV1, FVC, PEF, FEF50 and FEF25 between NwA and Nw, but no statistically significant differences of lung function parameters were observed between ObA and NwA. We found an inverse relationship between HOMA-IR and all spirometric parameters, although without any statistical significance. We also observed a significantly lower FVC in insulin-resistant children (HOMA-IR>95th percentile) (p=0.03).

Conclusions:
This study suggests that lung function could be early altered in obese children, already in pre-pubertal age. Although IR should not manifest its effects on lungs in pre-pubertal obese children, the prevention or treatment of obesity in the pre-pubertal period may prevent definitive negative effects on lungs.