bluuebunny/crossref_metadata_2025_split huggingface dataset:
The temporal dependence of exploration on neotic style in birds
Authors: O’Hara Mark , Mioduszewska Berenika , von Bayern Auguste , Auersperg Alice , Bugnyar Thomas , Wilkinson Anna , Huber Ludwig , Gajdon Gyula Koppany 
Published: June 2017

AbstractExploration (interacting with objects to gain information) and neophobia (avoiding novelty) are considered independent traits shaped by the socio-ecology of a given species. However, in the literature it is often assumed that neophobia inhibits exploration. Here, we investigate how different approaches to novelty (fast or slow) determine the time at which exploration is likely to occur across a number of species. We presented four corvid and five parrot species with a touchscreen discrimination task in which novel stimuli were occasionally interspersed within the familiar training stimuli. We investigated the likelihood that an animal would choose novelty at different stages of its training and found evidence for a shift in the pattern of exploration, depending on neotic style. The findings suggest that faster approaching individuals explored earlier, whilst animals with long initial approach latencies showed similar amounts of exploration but did so later in training. Age rather than species might have influenced the amount of total exploration, with juveniles exploring more than adults. Neotic style varied consistently only for one species and seems to involve a strong individual component, rather than being a purely species-specific trait. This suggests that variation in behavioural phenotypes within a species may be adaptive.
Influence of tensile-strain-induced oxygen deficiency on metal-insulator transitions in NdNiO3−δ epitaxial thin films
Authors: Heo Seungyang , Oh Chadol , Son Junwoo , Jang Hyun Myung 
Published: June 2017

AbstractWe report direct evidence that oxygen vacancies affect the structural and electrical parameters in tensile-strained NdNiO3−δ epitaxial thin films by elaborately adjusting the amount of oxygen deficiency (δ) with changing growth temperature TD. The modulation in tensile strain and TD tended to increase oxygen deficiency (δ) in NdNiO3−δ thin films; this process relieves tensile strain of the thin film by oxygen vacancy incorporation. The oxygen deficiency is directly correlated with unit-cell volume and the metal-insulator transition temperature (TMI), i.e., resulting in the increase of both unit-cell volume and metal-insulator transition temperature as oxygen vacancies are incorporated. Our study suggests that the intrinsic defect sensitively influences both structural and electronic properties, and provides useful knobs for tailoring correlation-induced properties in complex oxides.
Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice
Authors: Sasayama Daimei , Sugiyama Nobuhiro , Yonekubo Shigeru , Pawlak Akiko , Murasawa Hiroyasu , Nakamura Mie , Hayashi Morimichi , Ogawa Takashi , Moro Makoto , Washizuka Shinsuke , Amano Naoji , Hongo Kazuhiro , Ohnota Hideki 
Published: June 2017

AbstractHormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity and depressive symptoms. To delineate potential effects of ERβ activation in postmenopausal women, we investigated the effects of a novel oestrogen receptor β-selective ligand (C-1) in ovariectomized mice. Uterine weight, depressive behaviour, and weight gain were examined in sham-operated control mice and ovariectomized mice administered placebo, C-1, or 17β-oestradiol (E2). Administration of C-1 or E2 reduced body weight gain and depressive-like behaviour in ovariectomized mice, as assessed by the forced swim test. In addition, administration of E2 to ovariectomized mice increased uterine weight, but administration of C-1 did not result in a significant increase in uterine weight. These results suggest that the selective activation of ERβ in ovariectomized mice may have protective effects against obesity and depressive-like behaviour without causing an increase in uterine weight. The present findings raise the possibility of the application of ERβ-ligands such as C-1 as a novel treatment for obesity and depression in postmenopausal women.
A Novel Unsupervised Algorithm for Biological Process-based Analysis on Cancer
Authors: Song Tianci , Cao Sha , Tao Sheng , Liang Sen , Du Wei , Liang Yanchun 
Published: June 2017

AbstractThe aberrant alterations of biological functions are well known in tumorigenesis and cancer development. Hence, with advances in high-throughput sequencing technologies, capturing and quantifying the functional alterations in cancers based on expression profiles to explore cancer malignant process is highlighted as one of the important topics among cancer researches. In this article, we propose an algorithm for quantifying biological processes by using gene expression profiles over a sample population, which involves the idea of constructing principal curves to condense information of each biological process by a novel scoring scheme on an individualized manner. After applying our method on several large-scale breast cancer datasets in survival analysis, a subset of these biological processes extracted from corresponding survival model is then found to have significant associations with clinical outcomes. Further analyses of these biological processes enable the study of the interplays between biological processes and cancer phenotypes of interest, provide us valuable insights into cancer biology in biological process level and guide the precision treatment for cancer patients. And notably, prognosis predictions based on our method are consistently superior to the existing state of art methods with the same intention.
A Storage Ring Based Free-Electron Laser for Generating Ultrashort Coherent EUV and X-ray Radiation
Authors: Feng Chao , Zhao Zhentang 
Published: June 2017

AbstractGeneration of ultrashort coherent radiation pulses in the extreme ultraviolet (EUV) and x-ray regime is of remarkable interest in the synchrotron radiation user community. In this work, a novel technique is proposed for directly imprinting strong coherent microbunching on the electron beam with very small laser-induced energy spread. Theoretical analysis and numerical simulations demonstrated that this technique can be used for the generation of megawatt-scale level, fully temporal coherent femtosecond EUV and soft x-ray radiation pulses at a storage ring light source.
Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization
Authors: Gannavaram Sreenivas , Torcivia John , Gasparyan Lusine , Kaul Amit , Ismail Nevien , Simonyan Vahan , Nakhasi Hira L. 
Published: June 2017

AbstractNo licensed human vaccines are currently available against leishmaniasis. Several anti-leishmanial vaccines are currently undergoing testing, including genetically modified live-attenuated parasite vaccines. Studies with live attenuated Leishmania vaccines such as centrin deleted Leishmania donovani parasites (LdCen−/−) showed protective immunity in animal models. Such studies typically examined the biomarkers of protective immunity however the biomarkers of attenuation in the parasite preparations have not received adequate attention. As several candidate vaccines enter clinical trials, a more complete product characterization to enable maintenance of product quality will help meet regulatory requirements. Towards this goal, we have determined the complete genome sequence of LdCen−/− and its parent strain Ld1S-2D (LdWT) and characterized the LdCen−/− vaccine strain using bioinformatics tools. Results showed that the LdCen−/− parasites, in addition to loss of the centrin gene, have additional deletions ranging from 350 bp to 6900 bp in non-contiguous loci on several chromosomes, most commonly in untranslated regions. We have experimentally verified a subset of these adventitious deletions that had no impact on the attenuation of the LdCen−/− parasites. Our results identified hitherto unknown features of attenuation of virulence that could be used as markers of product quality in production lots and highlight the importance of product characterization in parasitic vaccines.
Metodología de elaboración de un glosario bilingüe y bidireccional (inglés-español/español-inglés) basado en corpus para la traducción de manuales de instrucciones de televisores
Authors: Seghiri Miriam 
Published: June 2017

Abstract
The sources of information that translators may use are extremely varied, ranging from oral consultation with an expert to a search using specialised dictionaries and glossaries. Nowadays, however, one the most relevant documentation activities in the field of Translation involves the use of Internet resources and, closely related to this, the compilation and management of virtual corpora. For this reason, in the present paper we present a systematic methodology for extracting bilingual and bidirectional glossaries (English-Spanish/Spanish-English) based on parallel corpora to translate TV User Manuals. In fact, according to art. 5 of the Council Resolution of 17 December 1998 on operating instructions for technical consumer goods (98/C 411/01) it is essential to control the quality when writing and translating these manuals. In order to illustrate this methodology we focus on corpus design (according to the skopo) and on the compilation protocol (in four steps: searching, downloading, text formatting and saving data) in order to ensure quality. As for the quantity, we check the quantitative representativeness with the ReCor software (cfr. Seghiri 2006: 387). Once the corpus is representative from the qualitative and the quantitative points of view, it can be managed with a concordance program. So, we illustrate how to extract the terms semiautomatically in order to build a bilingual and bidirectional glossary with a parallel concordance named ParaConc. Thus, in the present paper we combine the main resource for researchers (cfr. Bowker 1998; Varantola 2000; Seghiri 2011) within the Translation field: corpora, in order to ensure quality; and the main documentation resource for prospective translators (cfr. Corpas et al. 2001): bilingual glossaries.
Searching for “Agent Zero”
Authors: van den Bos Jackie , Meakins Felicity , Algy Cassandra 
Published: June 2017

AbstractGurindji Kriol, a mixed language spoken in northern Australia, combines a Kriol VP with a Gurindji NP, including case suffixes (Meakins 2011a). The Gurindji-derived case suffixes have undergone a number of changes in Gurindji Kriol, for example the ergative suffix -ngku/-tunow marks nominative case (Meakins 2011b,2015). This study explores a new innovation in case morphology among Gurindji Kriol-speaking children: the use of -ngku/-tuto mark possessors as well as subjects, i.e. the emergence of a relative case system. Although rare in Australian languages, syncretism between agents and possessors is not uncommon cross-linguistically, reported in Caucasian Eskimo-Aleut, Mixe-Zoquean and Yucatecan-Mayan languages (Allen 1964;Blake 1994;Palancar 2002). In the case of Gurindji Kriol, the relative case system found its origins in allomorphic reduction which led to syncretism between ergative and dative case forms. This syncretism was shaped by the syntactic grouping of subjects and possessors as dependents of verbs and possessums, respectively. Although partial syncretism between ergative and dative case is not unusual in Australian languages historically, it has gone to completion in Gurindji Kriol and can be observed in two other instances of rapid linguistic change in Australia: Ngiyambaa (Donaldson 1980) and Dyirbal (Schmidt 1985). The re-organisation of the case system can be traced back to a small group of second-generation Gurindji Kriol speakers at Nitjpurru (Pigeon Hole) and this change has since been transmitted laterally through familial connections to other children at Daguragu. There are also indications that it has begun propagating to other children at Kalkaringi and is now being acquired by the next generation of Gurindji Kriol speakers.
A language learner’s target language-mediated socializing in an affinity space in the host country
Authors: Fukada Yoshifumi 
Published: June 2017

AbstractThe number of international students keeps increasing worldwide. This is partly attributed to their expectation of improving their language skills by actually using the target language (TL) in the host countries. However, past studies show that such opportunities are not automatically given to them. Perceiving himself as one English learner, the author conducted an autoethnography to explore the processes of availing of opportunities to use the TL in Hawaii during his sabbatical. By recording observations and informal interviews in a diary of his own TL-mediated socialization, the author found that he could engage himself as an active social agent within a type of social space called affinity space which greatly promoted his situated TL-learning in naturalistic contexts. The author discusses how his own case can be applied to other learners studying abroad and presents some educational implications.
Feeding of the water extract from Ganoderma lingzhi to rats modulates secondary bile acids, intestinal microflora, mucins, and propionate important to colon cancer
Authors: Yang Yongshou , Nirmagustina Dwi Eva , Kumrungsee Thanutchaporn , Okazaki Yukako , Tomotake Hiroyuki , Kato Norihisa 
Published: June 2017

Abstract
Consumption of reishi mushroom has been reported to prevent colon carcinogenesis in rodents, although the underlying mechanisms remain unclear. To investigate this effect, rats were fed a high-fat diet supplemented with 5% water extract from either the reishi mushroom (Ganoderma lingzhi) (WGL) or the auto-digested reishi G. lingzhi (AWGL) for three weeks. Both extracts markedly reduced fecal secondary bile acids, such as lithocholic acid and deoxycholic acid (colon carcinogens). These extracts reduced the numbers of Clostridium coccoides and Clostridium leptum (secondary bile acids-producing bacteria) in a per g of cecal digesta. Fecal mucins and cecal propionate were significantly elevated by both extracts, and fecal IgA was significantly elevated by WGL, but not by AWGL. These results suggest that the reishi extracts have an impact on colon luminal health by modulating secondary bile acids, microflora, mucins, and propionate that related to colon cancer.
MicroRNA-210 alleviates oxidative stress-associated cardiomyocyte apoptosis by regulating BNIP3
Authors: Diao Hongying , Liu Bin , Shi Yongfeng , Song Chunli , Guo Ziyuan , Liu Ning , Song Xianjing , Lu Yang , Lin Xiaoye , Li Zhuoran 
Published: June 2017

Abstract
Oxidative stress-induced myocardial apoptosis and necrosis are involved in ischemia/reperfusion (I/R) injury. This study was performed to investigate microRNA (miR)-210’s role in oxidative stress-related myocardial damage. The expression of miR-210 was upregulated in myocardial tissues of I/R rats, while that of Bcl-2 adenovirus E1B 19kDa-interacting protein 3 (BNIP3) was downregulated. To simulate in vivo oxidative stress, H9c2 cells were treated with H2O2 for 48 h. MiR-210 level was increased upon H2O2 stimulation, peaked at 8 h, and then decreased. An opposite expression pattern of BNIP3 was observed. BNIP3 was demonstrated as a direct target of miR-210 via luciferase reporter assay. H2O2-induced cell apoptosis was attenuated by miR-210 mimics, whereas aggravated by miR-210 inhibitor. MiR-210 knockdown-induced cell apoptosis in presence of H2O2 was attenuated by BNIP3 siRNA. Our work demonstrates that miR-210 plays a protective role in H2O2-induced cardiomyocyte apoptosis at least by regulating the pro-apoptotic BNIP3.
The Cluster-EAGLE project: global properties of simulated clusters with resolved galaxies
Authors: Barnes David J. , Kay Scott T. , Bahé Yannick M. , Dalla Vecchia Claudio , McCarthy Ian G. , Schaye Joop , Bower Richard G. , Jenkins Adrian , Thomas Peter A. , Schaller Matthieu , Crain Robert A. , Theuns Tom , White Simon D. M. 
Published: June 2017

AbstractWe introduce the Cluster-EAGLE (c-eagle) simulation project, a set of cosmological hydrodynamical zoom simulations of the formation of 30 galaxy clusters in the mass range of 1014 &lt; M200/M⊙ &lt; 1015.4 that incorporates the Hydrangea sample of Bahé et al. (2017). The simulations adopt the state-of-the-art eagle galaxy formation model, with a gas particle mass of 1.8 × 106 M⊙ and physical softening length of 0.7 kpc. In this paper, we introduce the sample and present the low-redshift global properties of the clusters. We calculate the X-ray properties in a manner consistent with observational techniques, demonstrating the bias and scatter introduced by using estimated masses. We find the total stellar content and black hole masses of the clusters to be in good agreement with the observed relations. However, the clusters are too gas rich, suggesting that the active galactic nucleus (AGN) feedback model is not efficient enough at expelling gas from the high-redshift progenitors of the clusters. The X-ray properties, such as the spectroscopic temperature and the soft-band luminosity, and the Sunyaev–Zel'dovich properties are in reasonable agreement with the observed relations. However, the clusters have too high central temperatures and larger-than-observed entropy cores, which is likely driven by the AGN feedback after the cluster core has formed. The total metal content and its distribution throughout the intracluster medium are a good match to the observations.
Donor-Site Complications and Remnant of Rectus Abdominis Muscle Status after Transverse Rectus Abdominis Myocutaneous Flap Reconstruction
Authors: Chirappapha Prakasit , Trikunagonvong Noppadol , Prapruttam Duangkamon , Rongthong Sasiprapa , Lertsithichai Panuwat , Sukarayothin Thongchai , Leesombatpaiboon Monchai , Panawattanakul Rujira , Thaweepworadej Panya 
Published: June 2017

Background:
Transverse rectus abdominis myocutaneous (TRAM) flap reconstruction after mastectomy in breast cancer patients has become one of the milestones in breast reconstruction. There are several techniques that have been used in an attempt to minimize untoward complications. We present the whole muscle with partial sheath-sparing technique that focuses on the anatomy of arcuate line and the closure of the anterior abdominal wall techniques with mesh and determine factors associated with its complications and outcomes.

Methods:
We retrospectively and prospectively review the results of 30 pedicled TRAM flaps that were performed between November 2013 and March 2016, focusing on outcomes and complications.

Results:
Among the 30 pedicled TRAM flap procedures in 30 patients, there were complications in 5 patients (17%). Most common complications were surgical-site infection (7%). After a median follow-up time of 15 months, no patient developed abdominal wall hernia or bulging in daily activities in our study, but 6 patients (20%) had asymptomatic abdominal wall bulging when exercised. Significant factors related to asymptomatic exercised abdominal wall bulging included having a body mass index of more than 23 kg/m2.

Conclusion:
Pedicled TRAM flap by using the technique of the whole muscle with partial sheath-sparing technique combined with reinforcement above the arcuate line with mesh can reduce the occurrence of abdominal bulging and hernia.
Internet Stroke Preparedness for African American Women
Authors: Beal Claudia C. 
Published: June 2017

ABSTRACT

Background: African American women exhibit low stroke awareness and may benefit from experiential and lay language description of stroke symptoms. Objectives: The purpose of this pilot study was to examine the effect of an online stroke preparedness intervention for identification of stroke symptoms and appropriate action in response to suspected stroke and estimate effect sizes for a larger study. Methods: A quasi-experimental nonequivalent comparison group design was used to randomized 44 women to intervention (n = 23) or wait-list control group (n = 21). Data were analyzed with Friedman and Wilcoxon signed rank tests and Cochran-Mantel-Haenszel statistics to examine intervention effect on (1) self-efficacy to recognize stroke and know what to do in the event of stroke, (2) awareness of stroke symptoms, and (3) behavioral intent to call 911 for suspected stroke. Effect size estimates were calculated by converting z scores to r. Results: Significant intervention effect was found for self-efficacy to know what to do in the event of stroke, ability to identify stroke symptoms presented in written vignettes, and ability to identify correct action in response to symptoms presented in written vignettes. Small to medium effect sizes were obtained. No improvement was found for ability to name stroke symptoms. Behavioral intent to call 911 for stroke in someone else was high, but significantly fewer women would call 911 for themselves. Conclusions: Experiential depictions of stroke symptoms in an online format showed preliminary effectiveness to improve stroke awareness among African American women.
Vitamin K Antagonists Versus Novel Oral Anticoagulants for Elective Electrical Cardioversion of Atrial Fibrillation
Authors: Ţînţ Diana , Petriş Antoniu O. , Pop Ioana , Melnic Rimma , Ignat Andreea-Mihaela , Rogozea Liliana M. 
Published: June 2017

Background:
The management strategy for patients with atrial fibrillation (AF) is often very complex, electrical cardioversion (EC) being often used to restore sinus rhythm in those patients. The increased risk of thromboembolic complications was lowered using anticoagulation therapy. Usually, the anticoagulation was achieved using vitamin K antagonists (VKAs), but over the last years we witnessed a wide implementation of the novel oral anticoagulants (NOACs).

Study Question:
Study question was to compare the efficacy of NOACs versus VKAs in patients undergoing elective EC for persistent AF, by assessing the presence of left atrial spontaneous contrast and left atrial thrombi (LACS), as well as the occurrence of the thromboembolic events in the first month after the procedure.

Study Design:
A prospective study, including patients with persistent AF enrolled between January 1, 2015 and December 31, 2016, was conducted in 2 tertiary cardiology clinics. In all these patients, a management strategy based on EC was considered for the treatment of the disease. All patients received anticoagulant therapy for at least 3 weeks before cardioversion. The data of 103 patients were analyzed.

Results:
The patients were divided into 2 groups: group A—VKAs treated—included 45 patients (43.68%), mean age 65.3 ± 12.47, 36% women; group B—NOACs treated—included 58 patients (56.31%), mean age 66.4 ± 9.79, 46% women. There was a trend toward higher incidence of left atrial thrombi in group B (16.28%) versus group A (7.69%), but the difference was not statistically significant (P = 0.5). The incidence of LACS was 40% in group A and 29% in group B, (P = 0.54).

Conclusion:
There are no statistically significant differences between the transesophageal echocardiography characteristics of left atrium and left atrial appendage examinations in the patients who received anticoagulation with VKAs as compared to patients who received anticoagulation with NOACs.