bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breathing Mankind Thoughts
Authors: Jacquet Philippe 
Published: July 2016

Mankind has never been connected as it is now and as it will be tomorrow. Nowadays thanks to the rise of social networks such as Tweeter and Facebook, we can follow in real time the thought of millions of people. In fact we can almost feel the thoughts of a whole humanity and maybe project ourselves in a position where we could predict the major trends in the collective behavior of this humanity. However such an ambitious aim would require considerable resources in processing and networking which may be far from affordable. Indeed trends and topics are carried in a multiple of small texts written in various language and vocabularies like an hologram carries information in a dispersed way. Their capture and classification pose serious problems of data mining and analytics. Processes based on pure semantic analysis would require too much processing power and memory. We will present alternative methods based on string complexity also inspired on geolocalization in wireless networks which saves processing power by several order of magnitude. The ultimate goal is to detect when people are thinking about the very same topics before they become aware.
Beyond the problem of topic detection and classification one must also estimate the potential of an isolated topic to become a lasting trend. In other word one must probe the topic foundations, for example by challenging how trustworthy are its sources. Designing an efficient source finder algorithm is indissociable with building realistic models about topic propagation. If we suppose that topics propagate inside communities via the followers-followees links, the propagation is highly amplified by the unbalances in the graph topology. It is established that dominating and semi dominating nodes such as the CNN Tweeter site are the main accelerator of topic propagation. The difficulty is to find the actual source of a topic beyond those screening nodes and the search is prone to false positive and true negative effects. In fact we will show that finding a source of topic is similar to finding a common ancestor in a Darwin channel where spurious mutations complicate the task.
Hydrocortisone Counteracts Adverse Stress Effects on Dual-Task Performance by Improving Visual Sensory Processes
Authors: Weckesser Lisa J. , Alexander Nina C. , Kirschbaum Clemens , Mennigen Eva , Miller Robert 
Published: July 2016

Abstract
The impact of acute stress on executive processes is commonly attributed to glucocorticoid-induced disruptions of the pFC. However, the occipital cortex seems to express a higher density of glucocorticoid receptors. Consequently, acute stress effects on executive processes could as well be mediated by glucocorticoid (e.g., cortisol)-induced alterations of visual sensory processes. To investigate this alternative route of stress action by demarcating the effects of acute stress and cortisol on executive from those on visual sensory processes, 40 healthy young men completed a standardized stress induction (i.e., the Trier Social Stress Test) and control protocol in two consecutive sessions. In addition, they received either a placebo or hydrocortisone (0.12-mg/kg bodyweight) pill and processed a dual and a partial report task to assess their executive and visual sensory processing abilities, respectively. Hydrocortisone administration improved both partial report and dual-task performance as indicated by increased response accuracies and/or decreased RTs. Intriguingly, the hydrocortisone-induced increase in dual-task performance was completely mediated by its impact on partial report performance (i.e., visual sensory processes). Moreover, RT measures in both tasks shared approximately 26% of variance, which was only in part attributable to hydrocortisone administration (ΔR2 = 8%). By contrast, acute stress selectively impaired dual-task performance (i.e., executive processes), presumably through an alternative route of action. In summary, the present results suggest that cortisol secretion (as mimicked by hydrocortisone administration) may counteract adverse residual stress effects on executive processes by improving visual sensory processes (e.g., the maintenance and amplification of task-relevant sensory information).
The Rapid Intensification of Hurricane Karl (2010): New Remote Sensing Observations of Convective Bursts from the Global Hawk Platform
Authors: Guimond Stephen R. , Heymsfield Gerald M. , Reasor Paul D. , Didlake Anthony C. 
Published: July 2016

Abstract
The evolution of rapidly intensifying Hurricane Karl (2010) is examined from a suite of remote sensing observations during the NASA Genesis and Rapid Intensification Processes (GRIP) field experiment. The novelties of this study are in the analysis of data from the airborne Doppler radar High-Altitude Imaging Wind and Rain Airborne Profiler (HIWRAP) and the new Global Hawk airborne platform that allows long endurance sampling of hurricanes. Supporting data from the High-Altitude Monolithic Microwave Integrated Circuit (MMIC) Sounding Radiometer (HAMSR) microwave sounder coincident with HIWRAP and coordinated flights with the NOAA WP-3D aircraft help to provide a comprehensive understanding of the storm. The focus of the analysis is on documenting and understanding the structure, evolution, and role of small-scale deep convective forcing in the storm intensification process. Deep convective bursts are sporadically initiated in the downshear quadrants of the storm and rotate into the upshear quadrants for a period of ~12 h during the rapid intensification. The aircraft data analysis indicates that the bursts are being formed and maintained through a combination of two main processes: 1) convergence generated from counterrotating mesovortex circulations and the larger vortex-scale flow and 2) the turbulent (scales of ~25 km) transport of anomalously warm, buoyant air from the eye to the eyewall at low levels. The turbulent mixing across the eyewall interface and forced convective descent adjacent to the bursts assists in carving out the eye of Karl, which leads to an asymmetric enhancement of the warm core. The mesovortices play a key role in the evolution of the features described above. The Global Hawk aircraft allowed an examination of the vortex response and axisymmetrization period in addition to the burst pulsing phase. A pronounced axisymmetric development of the vortex is observed following the pulsing phase that includes a sloped eyewall structure and formation of a clear, wide eye.
On the Predictability and Error Sources of Tropical Cyclone Intensity Forecasts
Authors: Emanuel Kerry , Zhang Fuqing 
Published: July 2016

Abstract
The skill of tropical cyclone intensity forecasts has improved slowly since such forecasts became routine, even though track forecast skill has increased markedly over the same period. In deciding whether or how best to improve intensity forecasts, it is useful to estimate fundamental predictability limits as well as sources of intensity error. Toward that end, the authors estimate rates of error growth in a “perfect model” framework in which the same model is used to explore the sensitivities of tropical cyclone intensity to perturbations in the initial storm intensity and large-scale environment. These are compared to estimates made in previous studies and to intensity error growth in real-time forecasts made using the same model, in which model error also plays an important role. The authors find that error growth over approximately the first few days in the perfect model framework is dominated by errors in initial intensity, after which errors in forecasting the track and large-scale kinematic environment become more pronounced. Errors owing solely to misgauging initial intensity are particularly large for storms about to undergo rapid intensification and are systematically larger when initial intensity is underestimated compared to overestimating initial intensity by the same amount. There remains an appreciable gap between actual and realistically achievable forecast skill, which this study suggests can best be closed by improved models, better observations, and superior data assimilation techniques.
Annual and Semiannual Cycle of Equatorial Atlantic Circulation Associated with Basin-Mode Resonance
Authors: Brandt Peter , Claus Martin , Greatbatch Richard J. , Kopte Robert , Toole John M. , Johns William E. , Böning Claus W. 
Published: July 2016

AbstractSeasonal variability of the tropical Atlantic circulation is dominated by the annual cycle, but semiannual variability is also pronounced, despite weak forcing at that period. This study uses multiyear, full-depth velocity measurements from the central equatorial Atlantic to analyze the vertical structure of annual and semiannual variations of zonal velocity. A baroclinic modal decomposition finds that the annual cycle is dominated by the fourth mode and the semiannual cycle is dominated by the second mode. Similar local behavior is found in a high-resolution general circulation model. This simulation reveals that the annual and semiannual cycles of the respective dominant baroclinic modes are associated with characteristic basinwide structures. Using an idealized, linear, reduced-gravity model to simulate the dynamics of individual baroclinic modes, it is shown that the observed circulation variability can be explained by resonant equatorial basin modes. Corollary simulations of the reduced-gravity model with varying basin geometry (i.e., square basin vs realistic coastlines) or forcing (i.e., spatially uniform vs spatially variable wind) show a structural robustness of the simulated basin modes. A main focus of this study is the seasonal variability of the Equatorial Undercurrent (EUC) as identified in recent observational studies. Main characteristics of the observed EUC including seasonal variability of transport, core depth, and maximum core velocity can be explained by the linear superposition of the dominant equatorial basin modes as obtained from the reduced-gravity model.
Retention during capsule endoscopy: Is it a real problem in routine practice?
Authors: Ormeci Asli Cifcibasi , Akyuz Filiz , Baran Bulent , Gokturk Suut , Ormeci Tugrul , Pinarbasi Binnur , Mutluay Soyer Ozlem , Evirgen Sami , Akyuz Umit , Karaca Cetin , Demir Kadir , Kaymakoglu Sabahattin , Besisik Fatih 
Published: July 2016

Objective This study evaluated the risks and outcomes of capsule retention during capsule endoscopy (CE) for investigating small bowel disease. Capsule retention is the most serious complication of CE. Methods Before CE, the gastrointestinal tract was evaluated for blockages with computerized tomography. Analysis of CE was made retrospectively. Results Capsule endoscopy was used to investigate obscure bleeding (90.2%; n = 324) or other symptoms (9.8%; n = 35). The capsule retention rate was 11/359 (3.1%); it was retained in a malignant lesion area (adenocarcinoma or melanoma) in two patients (18.2%), in the small bowel in an ulcerated area in five patients (45.5%), and in the oesophagus/stomach in four patients (36.4%) due to dysmotility. None of the patients had symptoms of obstruction. Conclusions Scanning patients before CE did not predict capsule retention. Retention is a complication of CE, but occurs as a result of the underlying disease. The risk of retention is increased in patients with motility disorders, suspected small bowel ulcers or malignancies.
What Does It Cost to Improve Household Diets in Nepal? Using the Cost of the Diet Method to Model Lowest Cost Dietary Changes
Authors: Biehl Erin , Klemm Rolf D. W. , Manohar Swetha , Webb Patrick , Gauchan Devendra , West Keith P. 
Published: July 2016

Background: In Nepal, limited availability and affordability of nutritious foods contribute to malnutrition. Objectives: To identify nutrient deficiencies in commonly consumed diets and model lowest cost changes that could improve diet quality in 3 agroecological zones of Nepal. Methods: In August to September 2014, we collected market price and women’s food frequency data from 3 representative villages in Nepal’s mountains (Mahat Gaun, Jumla, n = 181 households), hills (Sitapur, Arghakhanchi, n = 166), and terai (Saigaun, Banke, n = 232) and verified local diets during women’s group discussions. Using the Cost of the Diet method, we compared models of the most nutritious version of a commonly consumed diet given locally available foods (“common diet”) with the cheapest possible diet meeting nutrient requirements, including foods not currently available (“optimal diet”). Results: The household common diet lacks sufficient vitamin B12, riboflavin, and calcium in the mountains; B6, B12, calcium, and iron in the hills; vitamin A, calcium, and iron in the terai. Adding fish to the mountain and hill diets and increasing dark green leafy vegetable consumption in all zones yielded nutritional adequacy. Optimal diets are more expensive than the common diet in the mountains and hills but less expensive in the terai. Conclusion: The modeled lowest cost diet commonly eaten in 3 Nepalese communities lacks key nutrients. Policies and interventions that increase market availability and consumption of vitamin B12- and calcium-rich fish and dark green leafy vegetables could improve local diets, particularly in the mountains and hills.
Tolerability of Enteral Nutrition in Mechanically Ventilated Patients With Septic Shock Who Require Vasopressors
Authors: Merchan Cristian , Altshuler Diana , Aberle Caitlin , Papadopoulos John , Schwartz David 
Published: July 2016

Purpose: Enteral nutrition (EN) is often held in patients receiving vasopressor support for septic shock. The rationale for this practice is to avoid mesenteric ischemia. The objective of this study is to evaluate the tolerability of EN in patients with septic shock who require vasopressor support and determine factors associated with tolerance of EN. Materials and Methods: This was a single-center retrospective review of adult patients admitted to the intensive care unit with a diagnosis of septic shock and an order for EN. The primary outcome was EN tolerance. Secondary outcomes included time to initiation of EN from the start of vasopressor(s), length of stay, and mortality. Results: A total of 120 patients were included. Sixty-two percent of patients tolerated EN. The most common reason for intolerance of EN was gastric residuals > 250 mL (74%). No reports of mesenteric ischemia were observed. A multivariate analysis demonstrated that patients with septic shock initiating EN within 48 hours and receiving norepinephrine-equivalent doses of 0.14 μg/kg/min or less were more likely to tolerate EN. Conclusion: Based on our observation, early EN may be tolerated and safely administered in patients with septic shock who are adequately fluid resuscitated and receive doses of < 0.14 μg/kg/min of norepinephrine equivalents.
Confidentiality, anonymity and amnesty for midwives in distress seeking online support – Ethical?
Authors: Pezaro Sally , Clyne Wendy , Gerada Clare 
Published: July 2016

Background: Midwife health is intrinsically linked to the quality of safe patient care. To ensure safe patient care, there is a need to deliver emotional support to midwives. One option that midwives may turn to may be a confidential online intervention, instead of localised, face-to-face support. Research design: Following the Realist And MEta-narrative Evidence Syntheses: Evolving Standards publication standards, this realist synthesis approach explores the ethical considerations in permitting confidentiality, anonymity and amnesty in online interventions to support midwives in work-related psychological distress. An iterative search methodology was used to select nine papers for review. To assimilate information, papers were examined for ideas relating to ethical dimensions of online interventions to support midwives in work-related psychological distress. This review takes a narrative approach. Findings: Online interventions can support the development of insight, help seeking and open discussion. Additionally, Internet support groups can become morally persuasive in nature. Anonymity and confidentiality are both effective and therapeutic features of online interventions when used in collaboration with effective online moderation. Yet, ethical dilemmas remain where users cannot be identified. Discussion: Confidentiality and anonymity remain key components of successful online interventions. However, sanctioning the corollary component of amnesty may provoke moral discomfort for those seeking immediate accountability. For others, amnesty is seen as essential for open disclosure and help seeking. Ultimately, the needs of midwives must be balanced with the requirement to protect the public and the professional reputation of midwifery. Conclusion: In supporting midwives online, the principles of anonymity, confidentiality and amnesty may evoke some resistance on ethical grounds. However, without offering identity protection, it may not be possible to create effective online support services for midwives. The authors of this article argue that the principles of confidentiality, anonymity and amnesty should be upheld in the pursuit of the greatest benefit for the greatest number of people.
Investigating the behavioural effects of a mobile-phone based home telehealth intervention in people with insulin-requiring diabetes: Results of a randomized controlled trial with patient interviews
Authors: Baron Justine Sita , Hirani Shashivadan Parbat , Newman Stanton Peter 
Published: July 2016

Introduction Evidence supporting home telehealth effects on clinical outcomes in diabetes is available, yet mechanisms of action for these improvements remain poorly understood. Behavioural change is one plausible explanation. This study investigated the behavioural effects of a mobile-phone based home telehealth (MTH) intervention in people with diabetes. It was hypothesized that MTH would improve self-efficacy, illness beliefs, and diabetes self-care. Methods A randomized controlled trial compared standard care to standard care supplemented with MTH (self-monitoring, data transmission, graphical and nurse-initiated feedback, educational calls). Self-report measures of self-efficacy, illness beliefs, and self-care were repeated at baseline, three months, and nine months. MTH effects were based on the group by time interactions in hierarchical linear models and effect sizes with 95% confidence intervals (CIs). Interviews with MTH participants explored the perceived effects of MTH on diabetes self-management. Results Eighty-one participants were randomized to the intervention ( n = 45) and standard care ( n = 36). Significant group by time effects were observed for five out of seven self-efficacy subscales. Effect sizes were large, particularly at nine months. Interaction effects for illness beliefs and self-care were non-significant, but effect sizes and confidence intervals suggested MTH may positively affect diet and exercise. In interviews, MTH was associated with increased awareness, motivation, and a greater sense of security. Improved self-monitoring and diet were reported by some participants. Discussion MTH empowers people with diabetes to manage their condition and may influence self-care. Future MTH research would benefit from investigating behavioural mechanisms and determining patient profiles predictive of greater behavioural effectiveness.
Protection against death and renal failure by renin-angiotensin system blockers in patients with diabetes and kidney disease
Authors: Shen Jian , Huang Yan-Mei , Song Xin-Nan , Hong Xue-Zhi , Wang Min , Ling Wei , Zhang Xiao-Xi , Zhao Hai-Lu 
Published: July 2016

Introduction: Angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) are widely used to block the renin-angiotensin system (RAS). Yet it remains uncertain whether these drugs are equally effective and safe. Methods: Systematic reviews and meta-analyses of ACEis/ARBs in diabetes and kidney disease published in PubMed, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases were searched for clinical outcomes including all-cause mortality, end-stage renal disease (ESRD), hyperkalemia and cough. Results: Eight meta-analyses included 2177–61,264 patients with follow-up of 6–108 months. RAS blockers reduced mortality (relative risk ratio (RR), 0.90, 95% confidence interval (CI), 0.86–0.95) without heterogeneity. The death protection was significant specifically with ACEis (RR, 0.85, 95% CI, 0.79–0.91), but not with ARBs. Protection against ESRD was homogenously evident by ARBs (RR, 0.79, 95% CI, 0.73–0.87), ACEis (RR, 0.79, 95% , 0.64–0.94), and both (RR, 0.79, 95% CI, 0.73–0.87). Significant side effects were hyperkalemia by ARBs (RR, 2.44, 95% CI, 1.13–5.26), and cough by ACEis (RR, 2.38, 95% CI, 1.75–3.22) Conclusions: In patients with diabetes and kidney disease, ACEis and ARBs are consistently protective for the development of ESRD. Use of ACEis alone additionally reduces deaths and increases the risk for cough. Use of ARBs alone increases the risk for hyperkalemia without additional benefit of death protection.
Surrogate and clinical endpoints in interventional cardiology: are statistics the brakes?
Authors: Waliszewski Matthias , Rittger Harald 
Published: July 2016

Background: Randomized controlled trials are the gold standard for demonstrating safety and efficacy of coronary devices with or without accompanying drug treatments in interventional cardiology. With the advent of last-generation drug-eluting stents having enhanced technical attributes and long-term clinical benefits, the proof of incremental angiographic or long-term clinical efficacy becomes more challenging. The purpose of this review is to provide an overview of the most common and alternative study endpoints in interventional cardiology and their potential reimbursement value. Moreover, we intend to describe the statistical limitations in order to demonstrate differences between potential treatment groups. Furthermore, careful endpoint recommendations for a given patient number are offered for future study designs. Methods: The number of patients per treatment group was estimated for various study designs such as noninferiority test hypotheses with hard clinical endpoints and various surrogate endpoints. To test for differences in various surrogate endpoint scenarios, the corresponding patient group sizes were explored. To evaluate these endpoints in terms of their reimbursement impact, preferred endpoints for technical appraisals in interventional cardiology at the National Institute of Health and Care Excellence (NICE) were used. Results: Even with the most stringent experimental control to reduce bias-introducing factors, studies with hard primary clinical endpoints such as the occurrence of major adverse cardiac events (MACE) or target-lesion revascularization (TLR) rates remain the gold standard, with numbers reaching into the 300–700 patient range per group. Study designs using loss in fractional-flow reserve (FFR) or stent-strut-coverage rates can be statistically formulated; however, the clinical ramifications for the patient remain to be discussed. Nonrandomized study designs with intrapatient angiographic controls in nontarget vessels may merit further thoughts and explorations. Conclusions: From a reimbursement impact, the primary endpoints MACE and TLR are the best choices for a moderately sized study population of 500 patients per group. Angiographic endpoints, in particular minimal lumen diameter (MLD), are not useful in this context. The emerging endpoints such as loss in FFR or stent coverage require smaller patient populations. However, their impact on reimbursement-related decisions is limited.