bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the construction process of supply chain ecosystem led by digital platform enterprises from the perspective of dynamic capability
Authors: Chi Kaoxun , Yan Fei , Zhang Chengxuan , Wang Jianping 
Published: September 2024

Purpose
Against the backdrop of the global reshaping of supply chains, supply chain ecosystems have emerged as a critical force in ensuring the high-quality development of enterprises and fostering stable economic growth. However, a systematic theoretical understanding of how to construct these supply chain ecosystems remains nascent. This study aims to explore the mechanism of the process of building supply chain ecosystems between digital innovation platform enterprises and digital trading platform enterprises from the perspective of dynamic capabilities.

Design/methodology/approach
An explanatory case study is conducted based on a theoretical framework grounded on dynamic capabilities view. Two preeminent digital platform enterprises in China (Haier and JD.com) are studied. The authors primarily conducted this research by collecting a large volume of these Chinese public materials.

Findings
First, the construction processes of supply chain ecosystems in both digital platform enterprises can be delineated into three stages: embryonic, development and maturity. Second, digital innovation platform enterprises’ construction process is primarily influenced by factors such as production and operational collaboration, consumer demand and research and development. This influence is exerted through interactions on digital platforms and within sub-ecosystems. Meanwhile, digital trading platform enterprises’ construction process is influenced by factors such as infrastructure development, consumer demand and financial support, driving dynamic capability formation through multi-party cooperation and ecological interactions based on conceptual identity.

Practical implications
In the establishment of supply chain ecosystems, digital platform enterprises should prioritize the cultivation of opportunity expansion, resource integration and symbiotic relationship capabilities. Furthermore, this study shows that digital platform enterprises need to actively adjust their interactive relationships with cooperating enterprises based on changes in the market, industry, policies and their own developmental stages.

Originality/value
This study addresses prior deficiencies in understanding the comprehensive construction of supply chain ecosystems and provides significant insights to enhance the theoretical foundation of supply chain ecosystem studies. Additionally, this paper uncovers the dynamic capability development behaviors and contextual features inherent in the construction process of supply chain ecosystems by digital platform enterprises.
Unveiling the nutrient‐wealth of black soybean: A holistic review of its bioactive compounds and health implications
Authors: Mitharwal Swati , Saini Ayushi , Chauhan Komal , Taneja Neetu K. , Oberoi Harinder Singh 
Published: September 2024

AbstractLegumes, an essential component of staple diets, hold a prominent place in global cuisines. Soybean stands out as a widely cultivated legume and is valued for its high protein content, dietary fiber, and rich micronutrients. Several varieties of soybean are available, of which black and yellow varieties show dominance in varied countries and cultures. Over time, the cultivation and consumption of black soybeans have markedly reduced compared to the yellow variety. Despite its rich nutritional and therapeutic indices, it has lost its usage over time. Traditionally, it was utilized in oriental medicine for detoxification and anti‐inflammatory potential. However, the antinutrients present in black soybean limit its utilization in the food sector due to their interference with overall nutrient absorption. Several studies in the last few decades have focused on reducing the content of antinutritional factors. However, the information on the use of different processing techniques, both singly and in blends, to reduce antinutrients and enhance the bioaccessibility, bioavailability, and bioactivity of bioactive compounds and varied nutrients is limited and fragmented. Furthermore, studies have highlighted black soybeans’ protective effects against various degenerative diseases. However, the studies on the effect of processing to enhance its antioxidative properties to make them a sought‐after food commodity with nutraceutical potential and therapeutic efficacy are limited and widely scattered. The review aims to consolidate knowledge of diverse processing methods to improve their nutritional and bioactive profile for wider applications in the food and pharmaceutical industries. Further, it has also highlighted its nutraceutical properties for developing varied functional foods against degenerative diseases to have better therapeutic efficacy.
Associations with early vomiting when using intranasal fentanyl and nitrous oxide for procedural sedation in children: A secondary analysis of a randomised controlled trial
Authors: Fauteux‐Lamarre Emmanuelle , Hearps Stephen , McCarthy Michelle , Quinn Nuala , Davidson Andrew , Legge Donna , Lee Katherine J , Palmer Greta M , Hopper Sandy M , Babl Franz E 
Published: September 2024

AbstractObjectiveIntranasal (IN) fentanyl and nitrous oxide (N2O) can be combined to provide procedural sedation and analgesia to children. This combination is advantageous because of rapid onset of action and non‐parenteral administration, but is associated with increased vomiting. We sought to describe the associations of demographic and procedural factors with early vomiting when using this combination in children.MethodsThis was a planned secondary analysis of a randomised controlled trial comparing the effect of oral ondansetron versus placebo at a single paediatric hospital. Children aged 3 to <18 years with planned procedural sedation with IN fentanyl and N2O were randomised to receive oral ondansetron or placebo prior to N2O administration. Vomiting was defined as early if occurring during or up to 1 h after N2O delivery. We assessed the relationship between early vomiting, demographic and procedural characteristics.ResultsParticipants were recruited between October 2016 and January 2019 and 62 out of 436 (14%) had early vomiting. The risk of early vomiting was 30% higher with higher total dose of fentanyl, risk ratio = 1.3 (95% confidence interval = 1.004–1.59). There was little evidence of a relationship between the occurrence of early vomiting and sex, age, weight, type of procedure, fasting duration, time between fentanyl administration and start of procedure, and procedure duration.ConclusionWe found that higher doses of IN fentanyl were associated with higher risk of early vomiting when administered with N2O in children. Other factors did not appear to be associated with vomiting.
Genome‐resolved metagenomics revealed novel microbial taxa with ancient metabolism from macroscopic microbial mat structures inhabiting anoxic deep reefs of a Maldivian Blue Hole
Authors: Doni Lapo , Azzola Annalisa , Oliveri Caterina , Bosi Emanuele , Auguste Manon , Morri Carla , Bianchi Carlo Nike , Montefalcone Monica , Vezzulli Luigi 
Published: September 2024

AbstractBlue holes are vertical water‐filled openings in carbonate rock that exhibit complex morphology, ecology, and water chemistry. In this study, macroscopic microbial mat structures found in complete anoxic conditions in the Faanu Mudugau Blue Hole (Maldives) were studied by metagenomic methods. Such communities have likely been evolutionary isolated from the surrounding marine environment for more than 10,000 years since the Blue Hole formation during the last Ice Age. A total of 48 high‐quality metagenome‐assembled genomes (MAGs) were recovered, predominantly composed of the phyla Chloroflexota, Proteobacteria and Desulfobacterota. None of these MAGs have been classified to species level (<95% ANI), suggesting the discovery of several new microbial taxa. In particular, MAGs belonging to novel bacterial genera within the order Dehalococcoidales accounted for 20% of the macroscopic mat community. Genome‐resolved metabolic analysis of this dominant microbial fraction revealed a mixotrophic lifestyle based on energy conservation via fermentation, hydrogen metabolism and anaerobic CO2 fixation through the Wood–Ljungdahl pathway. Interestingly, these bacteria showed a high proportion of ancestral genes in their genomes providing intriguing perspectives on mechanisms driving microbial evolution in this peculiar environment. Overall, our results provide new knowledge for understanding microbial life under extreme conditions in blue hole environments.
Extracellular vesicle‐encapsulated miR‐30c‐5p reduces aging‐related liver fibrosis
Authors: Rodrigues Alice C. , Heng Yujing J. , Slack Frank J. 
Published: September 2024

AbstractAging is associated with decreased health span, and despite the recent advances made in understanding the mechanisms of aging, no antiaging drug has been approved for therapy. Therefore, strategies to promote a healthy life in aging are desirable. Previous work has shown that chronic treatment with extracellular vesicles (EVs) from young mice prolongs lifespan in old mice, but the mechanism of action of this effect on liver metabolism is not known. Here we investigated the role of treatment with EVs derived from young sedentary (EV‐C) or exercised (EV‐EX) mice in the metabolism of old mice and aimed to identify key youthful‐associated microRNA (miRNA) cargos that could promote healthy liver function. We found that aged mice treated with either EV‐C or EV‐EX had higher insulin sensitivity, higher locomotor activity resulting in longer distance traveled in the cage, and a lower respiratory exchange ratio compared to mice treated with EVs from aged mice (EV‐A). In the liver, treatment with young‐derived EVs reduced aging‐induced liver fibrosis. We identified miR‐30c in the EVs as a possible youth‐associated miRNA as its level was higher in circulating EVs of young mice. Treatment of aged mice with EVs transfected with miR‐30c mimic reduced stellate cell activation in the liver and reduced fibrosis compared to EV‐negative control by targeting Foxo3. Our results suggest that by delivering juvenile EVs to old mice, we can improve their liver health. Moreover, we identified miR‐30c as a candidate for antiaging liver therapy.
Persuasion in veto bargaining
Authors: Kim Jenny S. , Kim Kyungmin , Van Weelden Richard 
Published: September 2024

AbstractWe consider the classic veto bargaining model but allow the agenda setter to engage in persuasion to convince the veto player to approve her proposal. We show that the proposer‐optimal can be achieved either by providing no information or with a simple binary experiment. Proposer chooses to reveal partial information when there is sufficient expected misalignment with Vetoer. In this case, the opportunity to engage in persuasion strictly benefits Proposer and increases the scope to exercise agenda power. We discuss applications and how the optimal experiment can be implemented in practice.
First report of surgery for congenital biliary dilatation using the hinotori™ Surgical Robot System (with video)
Authors: Okui Norimitsu , Kawasaki Yota , Matsumoto Ryu , Okumura Takashi , Oi Hideyuki , Idichi Tetsuya , Yamasaki Yoichi , Mataki Yuko , Ohtsuka Takao 
Published: September 2024

AbstractRobot‐assisted surgery for congenital biliary dilatation has been evolving primarily with the da Vinci® Surgical System. The hinotori™ Surgical Robot System, developed in Japan, received approval for gastroenterological surgery in 2022. We present the inaugural case of congenital biliary dilatation surgery utilizing the hinotori™ system. A 57‐year‐old woman was referred to our institution for evaluation and treatment of common bile duct dilatation classified under Todani Type Ia congenital biliary dilatation. Robotic resection of the extrahepatic bile duct and hepaticojejunostomy with Roux‐en‐Y were performed. The operation lasted 292 min with minimal blood loss (10 mL). The patient had an uneventful postoperative course and was discharged 10 days after surgery. Robotic surgery using the hinotori™ system for congenital biliary dilatation can be safely performed.
Efficacy and safety of recombinant human thrombopoietin for the treatment of chronic primary immune thrombocytopenia in children and adolescents: A multicentre, randomized, double‐blind, placebo‐controlled phase III trial
Authors: Ma Jingyao , Zhang Xiaoli , Zhao Libo , Wu Xiaoyan , Yao Yanhua , Liu Wei , Wang Xiaohuan , Ju Xiuli , Shi Xiaodong , Sun Lirong , Zheng Lili , Liu Shu , Qian Jun , Wu Runhui 
Published: September 2024

SummaryThe efficacy and safety of recombinant human thrombopoietin (rhTPO) in children and adolescent patients with chronic primary immune thrombocytopenia (ITP) remains unclear. A multicentre, randomized, double‐blind, placebo‐controlled phase III trial was performed. Patients aged 6–17 years, diagnosed with ITP and resistant or relapsed to corticosteroid treatment were included. For the trial, part 1 was exploratory and part 2 was the main analysis, with part 1 determining whether part 2 was stratified by age. Patients in part 1 were treated with rhTPO (the 6‐ to 11‐/12‐ to 17‐year‐old groups; 1:1). Patients in part 2 were randomized (3:1) to receive either rhTPO treatment or placebo. Patients received rhTPO or placebo at a dose of 300 U/kg once daily for up to 14 days. A total of 68 patients were included [part 1 (12 patients), part 2 (56 patients)]. The total response rate (TRR) in part 1 was 50.0% (95% CI: 21.09%–78.91%). For part 2, the TRR was 58.5% (95% CI: 42.11%–73.68%) and 13.3% (95% CI: 1.66%–40.46%) in the rhTPO and placebo groups (FAS) respectively. The difference in TRR between the rhTPO group and placebo group was 45.2% (95% CI: 22.33%–68.08%) and 44.6% (95% CI: 21.27%–67.85%) on the FAS and per‐protocol set (PPS), respectively, which indicates the superiority of rhTPO treatment.
A transcrestal sinus floor elevation strategy based on a haptic robot system: An in vitro study
Authors: Yu Shimin , Wang Yulan , Wang Yunxiao , Miron Richard J. , Yan Qi , Zhang Yufeng 
Published: September 2024

AbstractObjectivesTo reveal the force profiles recorded by haptic autonomous robotic force feedback during the transcrestal sinus floor elevation (TSFE) process, providing a reference for the surgery strategy during TSFE.Materials and methodsA total of 42 maxillary sinus models with different angles of the sinus floor (30°, 40°, 50°, 60°, 70°, 80°, and 90°, compared to vertical plane) were 3D printed. Implant site preparation was performed using a robotic system, and the total force (Ft) and axial force along the drill (Fz) during the surgery were recorded by the haptic robotic arm. The actual initial breakthrough point (drill contacting sinus floor) and complete breakthrough point (drill penetrating the sinus floor) were defined visually (the actual IBP and the actual CBP). The theoretical initial breakthrough point (the theoretical IBP) and the theoretical complete breakthrough point (the theoretical CBP) defined by the robot‐guided system and the CBCT were determined by real‐time force feedback and imaging distance measurement, respectively. The distance from the bottom of the resin model to the actual IBP and the actual CBP was defined as Di and Dt, respectively.ResultsThe difference in Fz began to increase significantly at 70°, while the difference in Ft became significant at 60°. When the angle was greater than 70°, there was no significant difference in the discrepancy between the actual and theoretical perforation points. Compared to judging the breakthrough point by CBCT, real‐time force feedback TSFE under robotic surgery achieved more accurate initial breakthrough point detection.ConclusionsThe smaller the angle, the larger the breakthrough force for the drill. The real‐time force feedback of haptic robotic system during TSFE could provide reliable reference for dentists. More clinical studies are needed to further validate the application of robotic surgery assisted TSFE.
Biomonitoring of hand and forearm transepidermal water loss and skin pH among nursing apprentices
Authors: Babić Željka , Šakić Franka , Macan Jelena 
Published: September 2024

AbstractBackgroundMeasurements of transepidermal water loss (TEWL) and stratum corneum (SC) pH can help indicate work‐related skin barrier damage, but sensitivity to confounding personal and ambient factors limits their potential as biomonitoring tools.ObjectivesTo evaluate the difference between hand and forearm skin barrier conditions as a tool for early recognition of workers with occupational contact dermatitis.Participants and MethodsThe participants were nursing apprentices (N = 238, median age 19 years) from Zagreb, Croatia. They filled out a questionnaire based on the Nordic Occupational Skin Questionnaire, underwent a clinical examination of skin on the hands, and were evaluated for their TEWL and SC pH on the dorsum of the hand and volar part of the forearm.ResultsWe found that the difference between hand and forearm TEWL values (ΔTEWL) greater than 7 g/m2/h, or >50%, or the difference in SC ΔpH >0.50, predicted visible skin changes found on clinical examination. However, only the association with ΔpH >0.50 retained statistical significance when controlled for sex, age, ambient temperature, and relative humidity in a multiple regression model.ConclusionsThe difference between hand and forearm SC pH values is suggested as a reliable biomonitoring tool in recognition of damaged skin barrier conditions in occupational settings.
Identifying Pareto‐efficient eradication strategies for invasive populations
Authors: Yackel Adams Amy A. , Hostetter Nathan J. , Link William A. , Converse Sarah J. 
Published: September 2024

AbstractInvasive species are a major cause of biodiversity loss and are notoriously expensive and challenging to manage. We developed a decision‐analytic framework for evaluating invasive species removal strategies, given objectives of maximizing eradication probability and minimizing costs. The framework uses an existing estimation model for spatially referenced removal data—one of the most accessible types of invasive species data—to obtain estimates of population growth rate, movement probability, and detection probability. We use these estimates in simulations to identify Pareto‐efficient strategies—strategies where increases in eradication probability cannot be obtained without increases in cost—from a set of proposed strategies. We applied the framework post hoc to a successful eradication of veiled chameleons (Chamaeleo calyptratus) and identified the potential for substantial improvements in efficiency. Our approach provides managers and policymakers with tools to identify cost‐effective strategies for a range of invasive species using only prior knowledge or data from initial physical removals.
‘Effects of dehydration on central blood pressure in young healthy adults’
Authors: Giddings Madeleine L. , Auringer Jacob P. , Meier Nathan F. , Lefferts Elizabeth C. , Wang Chong , Kane‐Barnese Lindsay 
Published: September 2024

AbstractPurposeBrachial blood pressure (BP) is the current gold standard for BP assessment; however, measures of pulse wave velocity (PWV) and central blood pressure (CBP) may contribute uniquely to assessment of cardiovascular health status. As of yet, standards for assessment of CBP and PWV have not addressed the impact of hydration status on proper measurement. To understand the impact of hydration, PWV and CBP should be measured in a euhydrated and hypohydrated state.MethodsForty‐three young, healthy participants (21 ± 2 years) completed a dehydration protocol utilizing moderate aerobic activity until they lost 1%–2% of their body weight. PWV and CBP were measured before and following the dehydration protocol. Linear regression was utilized to assess change in hydration status and change in PWV and CBP.ResultsNo significant relationships were observed between the change in hydration status (% body weight lost) and PWV (β = 0.05, p = 0.78) or central diastolic BP (β = −3.8, p = 0.10), however, a significant relationship was observed with central systolic BP (β = −5.0, p = 0.03).DiscussionIn conclusion, the assessment of hydration status before measurement of CBP or PWV may not be necessary in young, healthy individuals.
The association of glycaemic risk factors and diabetes duration with risk of heart failure in people with type 2 diabetes: A systematic review and meta‐analysis
Authors: Tabesh Mahtab , Sacre Julian W. , Mehta Kanika , Chen Lei , Sajjadi Seyeddeh Forough , Magliano Dianna J. , Shaw Jonathan E. 
Published: September 2024

AbstractAimsTo conduct a systematic review in order to better understand the association of glycaemic risk factors and diabetes duration with risk of heart failure (HF) in individuals with type 2 diabetes (T2D).MethodsWe identified longitudinal studies investigating the association of glycaemic factors (glycated haemoglobin [HbA1c], HbA1c variability, and hypoglycaemia) and diabetes duration with HF in individuals with T2D. Hazard ratios and odds ratios were extracted and meta‐analysed using a random‐effects model where appropriate. Risk of bias assessment was carried out using a modified Newcastle–Ottawa Scale. Egger's test along with the trim‐and‐fill method were used to assess and account for publication bias.ResultsForty studies representing 4 102 589 people met the inclusion criteria. The risk of developing HF significantly increased by 15% for each percentage point increase in HbA1c, by 2% for each additional year of diabetes duration, and by 43% for having a history of severe hypoglycaemia. Additionally, variability in HbA1c levels was associated with a 20%–26% increased risk of HF for each unit increase in the metrics of variability (HbA1c standard deviation, coefficient of variation, and average successive variability). All included studies scored high in the risk of bias assessment. Egger's test suggested publication bias, with trim‐and‐fill analyses revealing a significant 14% increased risk of HF per percentage point increase in HbA1c.ConclusionsGlycaemic risk factors and diabetes duration significantly contribute to the heightened risk of HF among individuals with T2D. A reduction in risk of HF is anticipated with better management of glycaemic risk factors.