bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and tolerability of the histone deacetylase inhibitor panobinostat in clinical practice
Authors: Baertsch Marc‐Andrea , Hillengass Jens , Blocka Joanna , Schönland Stefan , Hegenbart Ute , Goldschmidt Hartmut , Raab Marc S. 
Published: July 2017

AbstractThe histone deacetylase inhibitor panobinostat has shown efficacy in phase‐II and phase‐III trials for multiple myeloma and has recently received market approval in combination with bortezomib and dexamethasone. Here, we retrospectively report our single center experience with panobinostat/bortezomib/dexamethasone (FVD) in a heavily pretreated patient population (n = 24) with a high degree of refractoriness to proteasome inhibitors (PI) and immunomodulatory drugs (IMiD).Median age was 67 years (range 49‐87) and the median number of prior therapies was 5 (range 2‐17). Fourteen patients (58%) had high‐risk cytogenetic aberrations. Thirteen (54%) and 21 (88%) patients were refractory to PIs and IMiDs, respectively. Twelve patients (50%) were refractory to bortezomib and 7 (29%) to carfilzomib; 6 patients (25%) were refractory to both bortezomib and carfilzomib. In 21 patients evaluable for response, overall response rate (ORR; ≥PR) was 33% (7/21) and 81% (17/21) achieved at least stable disease. Median progression‐free survival (PFS) and overall survival were 3.5 and 9.8 months, respectively. Significant differences between bortezomib‐sensitive and ‐refractory patients were observed. In bortezomib‐sensitive patients, median PFS was 6.3 months compared to 2.3 months in bortezomib‐refractory patients (P < .001). Median overall survival was not reached vs 4.8 months (P = .046) in bortezomib‐sensitive and bortezomib‐refractory patients, respectively. The only patient refractory to carfilzomib but sensitive to bortezomib achieved very good partial remission and PFS of 6.3 months, suggesting discrete mechanisms of resistance to different PIs.As expected, thrombocytopenia and fatigue/asthenia occurred in nearly all patients (96% and 83%, respectively). Diarrhea was observed in only 19% of patients which compares favorably with the high rates of diarrhea reported in the PANORAMA trials. With panobinostat dose reductions in 67% of patients, FVD was tolerated by the majority of patients.In conclusion, FVD showed efficacy in a heavily pretreated, high‐risk multiple myeloma population with a high degree of patients refractory to novel agents including PIs.
Child physical punishment, parenting, and school readiness
Authors: Weegar Kelly , Guérin‐Marion Camille , Fréchette Sabrina , Romano Elisa 
Published: July 2017

AbstractThis study explored how physical punishment (PP) and other parenting approaches may predict school readiness outcomes. By using the Canada‐wide representative data, 5,513 children were followed over a 2‐year period. Caregivers reported on their use of PP and other parenting approaches (i.e., literacy and learning activities and other disciplinary practices) when children were 2–3 years old, whereas school readiness was measured at 4–5 years using interviewer‐administered tests of number competence and receptive vocabulary skills. Analyses controlled for PP use at 4–5 years, child externalizing behaviours, and various sociodemographics. Results indicated that PP does not directly predict school readiness; however, the effect of PP was moderated by other parenting approaches. Children's receptive vocabulary was weaker if caregivers used PP together with less frequent explaining/teaching regarding problem behaviour, or PP with less frequent engagement in literacy and learning activities. Children had weaker number competence when PP co‐occurred with more frequent psychological aggression (e.g., yelling/scolding). Results suggest that PP hinders children's school readiness when used alongside other parenting approaches, which reflects the reality of parenting (i.e., PP does not occur in isolation). Findings support early education efforts aimed at promoting early learning and literacy opportunities, as well as positive disciplinary strategies that do not involve PP.Highlights

We explored how physical punishment and other parenting approaches may predict school readiness outcomes using Canada‐wide data.
Results provided little evidence of positive effects of physical punishment on school readiness across a range of parenting and disciplinary contexts.
To promote school readiness, early education efforts should promote early learning opportunities and positive disciplinary strategies that do not involve physical punishment.
KIR2DS5 allotypes that recognize the C2 epitope of HLA‐C are common among Africans and absent from Europeans
Authors: Blokhuis Jeroen H. , Hilton Hugo G. , Guethlein Lisbeth A. , Norman Paul J. , Nemat‐Gorgani Neda , Nakimuli Annettee , Chazara Olympe , Moffett Ashley , Parham Peter 
Published: July 2017

AbstractIntroductionKIR2DS5 is an activating human NK cell receptor of lineage III KIR. These include both inhibitory KIR2DL1, 2 and 3 and activating KIR2DS1 that recognize either the C1 or C2 epitope of HLA‐C. In Europeans KIR2DS5 is essentially monomorphic, with KIR2DS5*002 being predominant. Pioneering investigations showed that KIR2DS5*002 has activating potential, but cannot recognize HLA‐A, ‐B, or ‐C. Subsequent studies have shown that KIR2DS5 is highly polymorphic in Africans, and that KIR2DS5*006 protects pregnant Ugandan women from preeclampsia. Because inhibitory C2‐specific KIR2DL1 correlates with preeclampsia, whereas activating C2‐specific KIR2DS1 protects, this association pointed to KIR2DS5*006 being an activating C2‐specific receptor. To test this hypothesis we made KIR‐Fc fusion proteins from all ten KIR2DS5 allotypes and tested their binding to a representative set of HLA‐A, ‐B and ‐C allotypes.ResultsSix African‐specific KIR2DS5 bound to C2+HLA‐C but not to other HLA class I. Their avidity for C2 is ∼20% that of C2‐specific KIR2DL1 and ∼40% that of C2‐specific KIR2DS1. Among the African C2 receptors is KIR2DS5*006, which protected a cohort of pregnant Ugandans from pre‐eclampsia. Three African KIR2DS5 allotypes and KIR2DS5*002, bound no HLA‐A, ‐B or ‐C. As a group the C2‐binding KIR2DS5 allotypes protect against pre‐eclampsia compared to the non‐binding KIR2DS5 allotypes. Natural substitutions that contribute to loss or reduction of C2 receptor function are at positions 127, 158, and 176 in the D2 domain.ConclusionsKIR2DS5*005 has the KIR2DS5 consensus sequence, is the only allele found at both centromeric and telomeric locations of KIR2DS5, and is likely the common ancestor of all KIR2DS5 alleles. That KIR2DS5*005 has C2 receptor activity, points to KIR2DS5*002, and other allotypes lacking C2 receptor function, being products of attenuation, a characteristic feature of most KIR B haplotype genes. Alleles encoding attenuated and active KIR2DS5 are present in both centromeric and telomeric locations.
The impact of an increased progesterone‐to‐follicle number ratio on live delivery rates in women with normal ovarian reserve
Authors: Chen Ya , Ma Ling , Wang Suqing 
Published: July 2017

AbstractObjectiveTo explore the relationship between progesterone–follicle number (P/F) ratio and live delivery rate in patients with normal ovarian reserve undergoing cleavage‐stage embryo transfer with a long gonadotropin‐releasing hormone agonist cycle.MethodsThe present retrospective study included data from patients younger than 38 years with normal ovarian reserve who were undergoing in vitro fertilization/intracytoplasmic sperm injection and embryo transfer at Zhongnan Hospital, Wuhan University, China, between January 1, 2009 and December 31, 2015. Patients underwent cleavage‐stage fresh embryo transfer with a long gonadotropin‐releasing hormone agonist cycle, and associations between P/F ratios and fertility/pregnancy outcomes were analyzed.ResultsPatients with a P/F ratio of 0.11 or above had higher serum progesterone levels (P<0.001) and lower serum estradiol levels (P<0.001) on the day of human chorionic gonadotropin administration in comparison with patients with lower P/F ratios; elevated P/F ratios were also associated with fewer follicles at least 14 mm in size (P<0.001) and lower live delivery rates (P<0.001). Multiple logistic regression confirmed that P/F ratio was an independent predictor of live delivery rate (P=0.001).ConclusionA P/F ratio of at least 0.11 was associated with lower live delivery rates in women with normal ovarian reserve undergoing cleavage‐stage embryo transfer with a long gonadotropin‐releasing hormone agonist cycle.
Assessment of genotoxicity and biodistribution of nano‐ and micron‐sized yttrium oxide in rats after acute oral treatment
Authors: Panyala Archana , Chinde Srinivas , Kumari Srinivas Indu , Grover Paramjit 
Published: July 2017

AbstractThe increasing use of yttrium oxide (Y2O3) nanoparticles (NPs) entails an improved understanding of their potential impact on the environmental and human health. In the present study, the acute oral toxicity of Y2O3 NPs and their microparticles (MPs) was carried out in female albino Wistar rats with 250, 500 and 1000 mg kg−1 body weight doses. Before the genotoxicity evaluation, characterization of the particles by transmission electron microscopy, dynamic light scattering and laser Doppler velocimetry was performed. The genotoxicity studies were conducted using micronucleus and comet assays. Results showed that Y2O3 NP‐induced significant DNA damage at higher dose (1000 mg kg−1 body weight) in peripheral blood leukocytes and liver cells, micronucleus formation in bone marrow and peripheral blood cells. The findings from biochemical assays depicted significant alterations in aspartate transaminase, alanine transaminase, alkaline phosphatase, malondialdehyde, superoxide dismutase, reduced glutathione, catalase and lactate dehydrogenase levels in serum, liver and kidneys at the higher dose only. Furthermore, tissue biodistribution of both particles was analyzed by inductively coupled plasma optical emission spectrometry. Bioaccumulation of yttrium (Y) in all tissues was significant and dose‐, time‐ and organ‐dependent. Moreover, Y2O3 NP‐treated rats exhibited higher tissue distribution along with greater clearance through urine whereas Y2O3 MP‐dosed animals depicted the maximum amount of Y in the feces. Hence, the results indicated that bioaccumulation of Y2O3 NPs via its Y ions may induce genotoxic effects.
Absence of Calcitriol Causes Increased Lactational Bone Loss and Lower Milk Calcium but Does Not Impair Post-lactation Bone Recovery in Cyp27b1 Null Mice
Authors: Gillies Brittany R , Ryan Brittany A , Tonkin Brett A , Poulton Ingrid J , Ma Yue , Kirby Beth J , St-Arnaud René , Sims Natalie A , Kovacs Christopher S 
Published: July 2017

ABSTRACT

We hypothesized that adaptation to calcium supply demands of pregnancy and lactation do not require calcitriol. Adult Cyp27b1 null mice lack calcitriol and have hypocalcemia, hypophosphatemia, and rickets. We studied wild-type (WT) and null sister pairs raised on a calcium-, phosphorus-, and lactose-enriched “rescue” diet that prevents hypocalcemia and rickets. Bone mineral content (BMC) increased &gt;30% in pregnant nulls, declined 30% during lactation, and increased 30% by 4 weeks post-weaning. WT showed less marked changes. Micro-CT revealed loss of trabecular bone and recovery in both genotypes. In lactating nulls, femoral cortical thickness declined &gt;30%, whereas endocortical perimeter increased; both recovered to baseline after weaning; there were no such changes in WT. Histomorphometry revealed a profound increase in osteoid surface and thickness in lactating nulls, which recovered after weaning. By three-point bend test, nulls had a &gt;50% decline in ultimate load to failure that recovered after weaning. Although nulls showed bone loss during lactation, their milk calcium content was 30% lower compared with WT. Serum parathyroid hormone (PTH) was markedly elevated in nulls at baseline, reduced substantially in pregnancy, but increased again during lactation and remained high post-weaning. In summary, pregnant Cyp27b1 nulls gained BMC with reduced secondary hyperparathyroidism, implying increased intestinal calcium delivery. Lactating nulls lost more bone mass and strength than WT, accompanied by increased osteoid, reduced milk calcium, and worsened secondary hyperparathyroidism. This implies suboptimal intestinal calcium absorption. Post-weaning, bone mass and strength recovered to baseline, whereas BMC exceeded baseline by 40%. In conclusion, calcitriol-independent mechanisms regulate intestinal calcium absorption and trabecular bone metabolism during pregnancy and post-weaning but not during lactation; calcitriol may protect cortical bone during lactation. © 2017 American Society for Bone and Mineral Research.
Do Undiagnosed Suicide Decedents Have Symptoms of a Mental Disorder?
Authors: Joiner Thomas E. , Buchman‐Schmitt Jennifer M. , Chu Carol 
Published: July 2017

BackgroundPsychological autopsy studies consistently report that the rate of detected mental disorders among suicide decedents is below 100%. This implies three possibilities: (a) a subset of suicide decedents did not have a mental disorder at the time of death; (b) all suicide decedents suffered from a mental disorder, but some were undetected due to methodological limitations; and/or (c) suicide decedents with an undetected mental disorder displayed significant and perhaps subclinical features of a mental disorder.ObjectiveIn this article, we examined these possibilities by evaluating the differences in symptoms and stressors between suicide decedents who were undiagnosed and those diagnosed with a mental disorder at the time of death.MethodWe reviewed 130 case studies of community‐based suicide decedents originally described in Robins’ (1981) psychological autopsy study.ResultsWithout exception, suicide decedents in Robins’ sample suffered either from a clearly diagnosable mental disorder or displayed features indicative of a significant, even if subclinical, presentation of a mental disorder. Undiagnosed and diagnosed suicide decedents did not significantly differ with regards to demographics, violence of suicide method, suicide attempt history, the number and intensity of stressful life events preceding death, and whether their death was a murder‐suicide.ConclusionAlthough clearly not all who suffer from mental disorders will die by suicide, these findings imply that all who die by suicide appear to exhibit, at minimum, subclinical psychiatric symptoms with the great majority showing prominent clinical symptoms. We conclude with clinical implications and recommendations for future study.
Interactions and effects of metal oxide nanoparticles on microorganisms involved in biological wastewater treatment
Authors: Cervantes‐Avilés Pabel , Díaz Barriga‐Castro Enrique , Palma‐Tirado Lourdes , Cuevas‐Rodríguez Germán 
Published: July 2017

AbstractTo clarify the toxicological effects of metal oxide nanoparticles (NPs) on microorganisms with environmental relevance, it is necessary to understand their interactions. In this work, they were studied the effects and the morphological interactions of two metal oxide NPs (ZnO and TiO2) with microorganisms, during aerobic treatment of wastewater. The effects were evaluated according to nutrient removal from wastewater, while morphological interactions were determined by three different techniques such as TEM, HAADF‐STEM, as well as an elemental mapping. According to results about effects of both NPs, they inhibited the removal of organic matter and ammonia nitrogen, and enhanced the orthophosphate removal. Related to morphological interactions, the electron‐dense material of both NPs was mainly observed bounded to cell membrane. In tests with ZnO NPs, it was also observed electron‐dense material internalized in microorganisms without physical damage in cell membrane. The elemental mapping was useful to determine that the electron‐dense material corresponded to Zn and Ti. Both interactions, internalization and attachment of NPs on cell membrane of microorganisms may trigger the negative effect in the removal of organic matter and nitrogen.
The Effects of a Counselor‐Led, Faith‐Based, School–Family–Community Partnership on Student Achievement in a High‐Poverty Urban Elementary School
Authors: Henry Lynette M. , Bryan Julia , Zalaquett Carlos P. 
Published: July 2017

School counselors play critical roles in partnerships with faith‐based organizations that provide valuable programs for students with economic challenges. This study evaluated the effects of a counselor‐led, faith‐based, school–family–community partnership on student reading achievement in a high‐poverty elementary school. Results indicated significantly higher reading gains for 3rd‐ through 5th‐grade students when compared with a control school without the partnership. Students in adopted classrooms experienced higher reading gains than did comparison samples. Gaps in reading achievement were closed between mentored and nonmentored students.Los consejeros escolares juegan un papel crítico en las colaboraciones con organizaciones de carácter religioso que proporcionan programas valiosos para estudiantes con dificultades económicas. Este estudio evaluó los efectos de una colaboración de carácter religioso, dirigida por un consejero, entre escuela‐familia‐comunidad, enfocada en el desarrollo de la lectura en una escuela primaria con niveles altos de pobreza. Los resultados indicaron unos logros en lectura significativamente más altos en estudiantes de 3° a 5° grado comparados con los de una escuela de control sin esta colaboración. Los estudiantes en las clases que adoptaron la colaboración experimentaron unos mayores logros en lectura que las muestras de comparación. Las brechas en los logros de lectura se cerraron entre estudiantes que recibieron mentorización y estudiantes sin mentorización.
Stepping Out, Stepping Up, and Staying Strong: Using Vigilance as a Tool for Preserving Rights and Promoting Social Justice
Authors: Parham William D. , Clauss‐Ehlers Caroline S. 
Published: July 2017

The 5th interviewee for the Hearing Our Elders series is Rod Kawakami, J.D. His reparations work during the 1980s on behalf of Gordon Hirabayashi, an American citizen of Japanese descent, for a civil rights violation alleged to have occurred 40 years earlier serves as the environmental backdrop for this compelling story of courage, commitment, and tenacity in the face of government collusion. The forthcoming narrative will highlight a slice of the life of Mr. Hirabayashi, a symbol of protest against anti‐Japanese sentiments that surfaced after the bombing of Pearl Harbor. This interview captured 6 overarching themes: (a) courage in the face of harsh and antagonistic social, political, and cultural environments; (b) enough is enough; (c) serendipity plays a part in launching historical events; (d) engage in creative problem‐solving strategies to address social injustice; (e) persevere until justice is served; and (f) follow one's commitment and passion.El 5° entrevistado en la serie Escuchar a Nuestros Mayores es Rod Kawakami, J.D. Su trabajo para lograr reparaciones durante los años 80 en nombre de Gordon Hirabayashi, un ciudadano estadounidense de origen japonés, por una violación de derechos civiles que supuestamente tuvo lugar 40 años antes sirve como el fondo ambiental de esta conmovedora historia de valor, compromiso y tenacidad ante la connivencia del gobierno. La expresiva narración destacará una parte de la vida del Sr. Hirabayashi, un símbolo de la protesta contra los sentimientos antijaponeses que surgieron tras el bombardeo de Pearl Harbor. Esta entrevista capturó seis temas fundamentales: (a) el valor ante un entorno cultural, político y social adverso y hostil; (b) ya basta; (c) la casualidad juega un papel en el desencadenamiento de hechos históricos; (d) resolver problemas de forma creativa para afrontar la injusticia social; (e) perseverar hasta que se haga justicia; y (f) seguir el propio sentido de compromiso y pasión.
Trust in work teams: An integrative review, multilevel model, and future directions
Authors: Costa Ana Cristina , Fulmer C. Ashley , Anderson Neil R. 
Published: July 2017

SummaryThis article presents an integrative review of the rapidly growing body of research on trust in work teams. We start by analyzing prominent definitions of trust and their theoretical foundations, followed by different conceptualizations of trust in teams emphasizing its multilevel, dynamic, and emergent nature. We then review the empirical research and its underlying theoretical perspectives concerning the emergence and development of trust in teams. On the basis of this review, we propose an integrated conceptual framework that organizes the field and can advance knowledge of the multilevel nature of trust in teams. Our conclusion is that trust in teams resides at multiple levels of analysis simultaneously, is subject to factors across levels in organizations, and impacts performance and other relevant outcomes both at the individual and team levels. We argue that research should not only differentiate between interpersonal trust between members from collective trust at the team level but also emphasize the interplay within and between these levels by considering cross‐level influences and dynamics. We conclude by proposing 4 major directions for future research and 3 critical methodological recommendations for study designs derived from our review and framework.
Biomechanical simulations of costo‐vertebral and anterior vertebral body tethers for the fusionless treatment of pediatric scoliosis
Authors: Aubin Carl‐Éric , Clin Julien , Rawlinson Jeremy 
Published: July 2017

ABSTRACTCompression‐based fusionless tethers are an alternative to conventional surgical treatments of pediatric scoliosis. Anterior approaches place an anterior (ANT) tether on the anterolateral convexity of the deformed spine to modify growth. Posterior, or costo‐vertebral (CV), approaches have not been assessed for biomechanical and corrective effectiveness. The objective was to biomechanically assess CV and ANT tethers using six patient‐specific, finite element models of adolescent scoliotic patients (11.9 ± 0.7 years, Cobb 34° ± 10°). A validated algorithm simulated the growth and Hueter–Volkmann growth modulation over a period of 2 years with the CV and ANT tethers at two initial tensions (100, 200 N). The models without tethering also simulated deformity progression with Cobb angle increasing from 34° to 56°, axial rotation 11° to 13°, and kyphosis 28° to 32° (mean values). With the CV tether, the Cobb angle was reduced to 27° and 20° for tensions of 100 and 200 N, respectively, kyphosis to 21° and 19°, and no change in axial rotation. With the ANT tether, Cobb was reduced to 32° and 9° for 100 and 200 N, respectively, kyphosis unchanged, and axial rotation to 3° and 0°. While the CV tether mildly corrected the coronal curve over a 2‐year growth period, it had sagittal lordosing effect, particularly with increasing initial axial rotation (>15°). The ANT tether achieved coronal correction, maintained kyphosis, and reduced the axial rotation, but over‐correction was simulated at higher initial tensions. This biomechanical study captured the differences between a CV and ANT tether and indicated the variability arising from the patient‐specific characteristics. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:254–264, 2018.