bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical Genome Mapping for Detection of BCR::ABL1—Another Tool in Our Toolbox
Authors: Tang Zhenya , Wang Wei , Toruner Gokce A. , Hu Shimin , Fang Hong , Xu Jie , You M. James , Medeiros L. Jeffrey , Khoury Joseph D. , Tang Guilin 
Published: October 2024

Background: BCR::ABL1 fusion is mostly derived from a reciprocal translocation t(9;22)(q34.1;q11.2) and is rarely caused by insertion. Various methods have been used for the detection of t(9;22)/BCR::ABL1, such as G-banded chromosomal analysis, fluorescence in situ hybridization (FISH), quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) and optical genome mapping (OGM). Understanding the strengths and limitations of each method is essential for the selection of appropriate method(s) of disease diagnosis and/or during the follow-up. Methods: We compared the results of OGM, chromosomal analysis, FISH, and/or RT-PCR in 12 cases with BCR::ABL1. Results: BCR:ABL1 was detected by FISH and RT-PCR in all 12 cases. One case with ins(22;9)/BCR::ABL1 was cryptic by chromosomal analysis and nearly missed by OGM. Atypical FISH signal patterns were observed in five cases, suggesting additional chromosomal aberrations involving chromosomes 9 and/or 22. RT-PCR identified the transcript isoforms p210 and p190 in seven and five cases, respectively. Chromosomal analysis revealed additional chromosomal aberrations in seven cases. OGM identified extra cytogenomic abnormalities in 10 cases, including chromoanagenesis and IKZF1 deletion, which were only detected by OGM. Conclusions: FISH offers rapid and definitive detection of BCR::ABL1 fusion, while OGM provides a comprehensive cytogenomic analysis. In scenarios where OGM is feasible, chromosomal analysis and RT-PCR may not offer additional diagnostic value.
Optimization of the Process of Extracting Polysaccharides from Agrocybe aegerita and In Vitro Antioxidant and Anti-Aging Tests
Authors: Wang Yuhan , Yang Jingyi , Li Xiang , Yang Jingshuo , Wang Honglei 
Published: October 2024

The extraction process of crude polysaccharides from Agrocybe aegerita was optimized, and the antioxidant and anti-aging effects of the crude polysaccharides were evaluated. The optimal extraction parameters for the polysaccharide were identified using the response surface methodology. The DPPH, hydroxy radical, and superoxide anion radical scavenging capacities were evaluated to determine the antioxidant properties of the AAPs. The effects of the AAPs on the lifespan, head-swing frequency, swallowing frequency, body-bending frequency, and stress resistance of Caenorhabditis elegans were determined. The optimal extraction conditions included a solid-to-liquid ratio that resulted in an extraction solution concentration of 0.034 g/mL, an extraction temperature of 92.64 °C, and an extraction time of 2.82 h. Under these conditions, the yield of the AAPs was 11.325% ± 0.996%. The IC50 of the AAPs for superoxide anion radical scavenging was 4.693 mg/mL. The AAPs reached their maximum activity at concentrations of about 2 mg/mL for DPPH and 5 mg/mL for the hydroxyl radical. The AAPs could prolong the lifespan and improve locomotion and the stress resistance of C. elegans. Our findings illustrate the potential of AAPs as an anti-aging and antioxidant agent, highlighting the use of this natural compound in the fields of food and pharmacology.
A Comprehensive Multi-Omics Study of Serum Alterations in Red Deer Infected by the Liver Fluke Fascioloides magna
Authors: Kuleš Josipa , Bujanić Miljenko , Rubić Ivana , Šimonji Karol , Konjević Dean 
Published: October 2024

Liver fluke infections are acknowledged as diseases with global prevalence and significant implications for both veterinary and public health. The large American liver fluke, Fascioloides magna, is a significant non-native parasite introduced to Europe, threatening the survival of local wildlife populations. The aim of this study was to analyze differences in the serum proteome and metabolome between F. magna-infected and control red deer. Serum samples from red deer were collected immediately following regular hunting operations, including 10 samples with confirmed F. magna infection and 10 samples from healthy red deer. A proteomics analysis of the serum samples was performed using a tandem mass tag (TMT)-based quantitative approach, and a metabolomics analysis of the serum was performed using an untargeted mass spectrometry-based metabolomics approach. A knowledge-driven approach was applied to integrate omics data. Our findings demonstrated that infection with liver fluke was associated with changes in amino acid metabolism, energy metabolism, lipid metabolism, inflammatory host response, and related biochemical pathways. This study offers a comprehensive overview of the serum proteome and metabolome in response to F. magna infection in red deer, unveiling new potential targets for future research. The identification of proteins, metabolites, and related biological pathways enhances our understanding of host–parasite interactions and may improve current tools for more effective liver fluke control.
Multimorbidity and person-centred care in a socioeconomically deprived community: a qualitative study
Authors: McCallum Marianne , Macdonald Sara , Mair Frances S 
Published: October 2024

BackgroundPeople with multimorbidity (>2 long-term conditions) have poorer outcomes in areas of high socioeconomic deprivation (SED). High-quality person-centred care (PCC) is important in those with multimorbidity, but socially vulnerable populations have not, to our knowledge, informed current PCC models.AimTo explore how wider community factors influence management of multimorbidity in the context of high SED, how high-quality PCC is defined by patients, and whether this influences healthcare management.Design and settingEthnographically informed case study in a community experiencing high SED in Scotland.MethodParticipant observation (138 h) was undertaken within four community groups who also took part in two participatory workshops. There were 25 in-depth interviews with people with multimorbidity, recruited from local general practices; emerging findings were discussed with interviewees in one focus group. Field notes/transcripts were analysed using inductive thematic analysis.ResultsKey aspects of PCC were ‘patient as person’, ‘strong therapeutic relationship’, ‘coordination of care’, and ‘power sharing’; power sharing was particularly enabling but rarely happened (barriers often unseen by practitioners). Shared community experiences of ‘being known’, ‘stigma’, and ‘none of the systems working’ influenced how people approached health services and healthcare decisions. High-quality PCC may have been particularly effective in this setting because of its influence on ameliorating wider shared negative community experiences.ConclusionIn a high SED setting PCC is important and can enhance engagement. Wider community factors have a critical influence on engagement with health care in areas of high SED and PCC may be particularly important in this context because of its influence ameliorating these. Policymakers should prioritise and resource PCC.
PEMBERDAYAAN IMAN KELUARGA KATOLIK MELALUI KEGIATAN LINGKUNGAN DI STASI SUMBER BENING DAN WIDODAREN PAROKI ST. YOSEF NGAWI
Authors: Wilhelmus Ola Rongan 
Published: October 2024

Many Catholic couples and families today prefer to choose the easy and shortcut way to solve the problems and challenges related to the family and marriage life. For example, problems of infidelity, economics, domestic violence are often resolved by divorce. This settlement proved to have many negative impacts on the family life. Recognizing these various family challenges and problems, the Surabaya Diocese's pastoral activities during 2023 focussing on the pastoral theme: Living Christ in the Family". During this period, families were guided through various Basic Christian Community's pastoral activities to explore the said pastoral theme. Those activities were part of empowering the faith of Catholic families. The research was conducted with the aim to identify the perception of Catholics at Sumber Bening and Widodaren Basic Christian Communities at Saint Yosef Parish, about the meaning of the Catholic family, discipleship in the family, and empowerment of the Catholic family's faith. The research used a quantitative approach, and the research model used was a survey. The research respondents were heads of Catholic families in the said two Basic Christian Communities. Data collection was carried out using questionnaire techniques, and the data was analyzed descriptively-statistically. The results of the study revealed that majority of respondents said that family is a community and living relationships between individuals who are imbued with the spirit of wholeness, love and gentleness. Families need to have a mature faith in Jesus Christ, and this mature faith requires better and more varied faith empowerment programs and strategies.
MODAL USAHA DAN PENGETAHUAN KEWIRAUSAHAAN APAKAH MEMPENGARUHI KINERJA UMKM KECAMATAN SYIAH KUALA KOTA BANDA ACEH?
Authors: Maulida Zenitha , Ridha Ainul , Nurbismi Nurbismi , Ivana Farah , Mediyati Sisca , Masyithah Syarifah Mauli 
Published: October 2024

This study aims to examine whether of influence business capital and entrepreneurial knowledge affect the performance of MSME in Syiah Kuala District, Banda Aceh City. The research method used is a quantitative. The population of this research is all MSME in Syiah Kuala District, Banda Aceh City, the population of which is 3.706 MSME units. The sampling technique used was purposive sampling and using the Slovin formula, namely 97 MSMEs. The data collection method uses a questionnaire distributed to MSMEs actors. The data analysis techniques used in this research descriptive statistic, multiple linear regression analysis, and hypothesis test both partially (t test) and simultaneously (F test) using SPSS application. The results of the study show that business capital and entrepreneurial knowledge have a positive and significant effect on the performance of MSMEs in Syiah Kuala District, Banda Aceh City, both partially and simultaneously.
Investigation of orientation behavior of nematic liquid crystals on UV-irradiated polyimide films
Authors: Tsukamoto Yuji , Maeda Hiroto , Saitou Takashi , Ozaki Ryotaro , Ozaki Masanori 
Published: October 2024

Abstract
The orientation mechanism of liquid crystals (LCs) on surfaces remains unclear, despite several methods for controlling pretilt angles. This study investigates the relationship between the surface condition of polyimide films, whose pretilt angles can be controlled by UV dose, and LC orientation behavior. Absorbance at wavelengths of 200 nm and 260 nm significantly decreases, while thickness reduces by approximately 4 nm. A rubbing treatment further decreases the thickness by approximately 2 nm. Atomic force microscopy confirmed the change in molecular conformation by UV-irradiation and rubbing treatment. The dispersive and polar components of the surface free energy of UV-irradiated polyimide films are evaluated, and it’s found that only the polar component changes with UV dose. Additionally, we confirm that the alignment of LCs transitions from homeotropic to planar with increased UV irradiation, demonstrating that pretilt angle distribution can be spatially controlled. These results contribute to establishing a photoalignment method for pretilt angle control.
Theoretical studies of the bipolar properties of ScAlN/AlGaN/GaN heterostructures for enhanced device applications
Authors: Li Wei , Xiao Hongling , Wang Xiaoliang , He Teng , Jiang Lijuan , Feng Chun , Xu Jiankai , Wang Qian , Zhou Miao 
Published: October 2024

Abstract
Here, we describe a systematic theoretical study of ScAlN/AlGaN/GaN heterostructures for enhanced high-electron-mobility transistors (HEMTs). We have investigated the carrier distributions and energy-band diagrams by solving the coupled Schrödinger and Poisson equations self-consistently. When the heterostructure is in the “off” state, the two-dimensional electron gas (2DEG) becomes increasingly depleted as the ScAlN thickness is increased to the critical thickness, at which point the two-dimensional hole gas (2DHG) appears. This critical thickness depends on the Sc content. Increasing the AlGaN thickness or Al content causes a simultaneous increase in the 2DEG and 2DHG sheet densities. In addition, when the HEMT is in the “on” state, 2DEG sheet density increases as ScAlN thickness increases, so long as the Sc content is less than 0.3; when the Sc content exceeds 0.4, this trend is reversed. For a given Sc content, double channels are produced when the ScAlN thickness exceeds the critical thickness.
Nonlinear polarization rotation based 635 nm praseodymium doped mode-locked fiber laser
Authors: Sultana Nasrin , Nishiura Masanori , Shioda Tatsutoshi 
Published: October 2024

Abstract
We demonstrated a mode-locked fiber laser oscillator using nonlinear polarization rotation as a saturable absorption system. The fiber laser generates mode-locked pulses by adjusting four waveplates. A single-clad Pr3+-doped single mode fluoride fiber with a 425 mW threshold pump power serves as the foundation for the ring cavity, which operates in the dissipative soliton resonance regime. The radio frequency signal-to-noise ratio of the pulses at 634.9 nm is 60 dB, maximum output power of 5.5 mW, and repetition rate of 34.5 MHz. These findings provide a foundation for the advancement of photonic applications in the visible spectrum.
CLASSES DE FÁRMACOS QUE PODEM CONTRIBUIR COMO FATORES DE RISCO PARA O INFARTO AGUDO DO MIOCÁRDIO
Authors: Saraiva Jane Tavares , Junior Omero Martins Rodrigues 
Published: October 2024

O infarto agudo do miocárdio (IAM) é uma condição clínica grave caracterizada pela interrupção do fluxo sanguíneo para o coração, resultando em dano ao músculo cardíaco. Entre os principais fármacos que podem gerar risco de IAM estão os anti-inflamatórios não esteroides (AINEs), especialmente em uso prolongado e em doses elevadas. Além disso, certos medicamentos para tratar transtornos psiquiátricos, como antidepressivos e antipsicóticos, têm sido associados a distúrbios metabólicos que aumentam a suscetibilidade a doenças cardiovasculares. Os contraceptivos orais, particularmente aqueles contendo estrogênio, também estão ligados a um aumento do risco de trombose e, consequentemente, de IAM, especialmente em mulheres com predisposição a problemas cardiovasculares. Fármacos utilizados para tratar distúrbios hormonais, como algumas terapias de reposição hormonal, podem agravar fatores de risco como hipertensão e dislipidemia. A avaliação cuidadosa da necessidade de uso de tais medicamentos, a escolha de alternativas mais seguras e o monitoramento rigoroso são medidas essenciais para minimizar o risco de IAM associado ao uso de fármacos. Observando a importância do tema que este artigo teve como objetivo Identificar as classes os fármacos que podem contribuir como fatores de risco para o infarto agudo do miocárdio, visando fornecer informações que ajudem na prevenção e manejo adequado dessas medicações em pacientes com predisposição a eventos cardiovasculares, visando fornecer subsídios para a elaboração de estratégias preventivas e terapêuticas mais seguras e eficazes. A metodologia usada foi uma revisão da literatura com base nas obras digitais disponíveis em plataformas digitais confiáveis. Para tanto concluímos que o futuro da farmacoterapia cardiovascular deve se concentrar na prevenção e manejo cuidadoso da cardiotoxicidade, com o objetivo de melhorar os resultados clínicos e a segurança dos pacientes.
TRENDS AND PATTERNS IN ONLINE PURCHASE DECISION RESEARCH A LITERATURE REVIEW AND BIBLIOMETRIC ANALYSIS
Authors: Sulistyowati Tussi 
Published: October 2024

Abstract :Â The internet has transformed the way consumers make purchase decisions, and with the increasing popularity of e-commerce, it has become vital to understand the factors that influence online purchase decisions. The COVID-19 pandemic has further accelerated the shift towards online shopping, making it even more crucial to understand the online purchase decision-making process. This bibliometric review examines 95 articles on the keyword "online purchase decision" from Scopus journals generated by Publish or Perish on April 25th, 2023, to identify the most influential authors and trends in this field from 2002 to 2023. The study reveals a steady rise in publications on this subject over time, with a significant surge in recent times. S. Yoon emerged as the most cited author in this field, followed by H.W. Kim and N. Hu. "Decision Support Systems" is the most productive journal in this field, and M. Ramesh is the most prolific author. The research variables have similarities and differences in focus and approach. For instance, trust, price, reviews, website characteristics, and the influence of social media are the focuses in these studies. The studies differ in their approaches and focuses. For example, (Yoon, 2002)Â examines the antecedents and consequences of trust, (Kim et al., 2012)Â compares price and trust, (Hu et al., 2014)Â analyzes online review sentiment, and (Luo et al., 2012)Â investigates the impact of website characteristics. There are also differences in the scope of the research, including cross-cultural approaches, the teenage market, gender, and potential customers vs. repeat customers. The findings of this study provide valuable insights into the key trends and patterns in online purchase decision-making research, which can inform marketing strategies and improve online salesKeyword : Keputusan Pembelian Online, AnalisisÂ Bibliometrik, Perilaku Konsumen
Review of Design Thinking Approach in Learning IoT Programming
Authors: Zainal Salbiah , Che Mohd Yusoff Rasimah , Abas Hafiza , Yaacub Suraya , Megat Zainuddin Norziha 
Published: October 2024

Internet of Things (IoT) is one of the keys for the Fourth Industrial Revolution (IR4.0) which refers to the use of intelligently connected devices and systems by embedded sensors and actuators in machines and other physical objects. With the pace of rapid IoT adoption, the demand for skilled IoT developers rises in tandem. This paper review the integration of design thinking as a pedagogical in IoT programming education. Topics on challenges in developing IoT systems, models, or frameworks for learning IoT programming, design thinking, design thinking approach in IoT system prototype development and teaching strategy technique have been discussed.
On the Origin of Quenched but Gas-rich Regions at Kiloparsec Scales in Nearby Galaxies
Authors: Jing Tao , Li Cheng 
Published: October 2024

Abstract
We use resolved spectroscopy from MaNGA to investigate the significance of both local and global properties of galaxies to the cessation of star formation at kpc scales. Quenched regions are identified from a sample of isolated disk galaxies by a single-parameter criterion D

n
(4000) -

log

EW(Hα)

>
1.6
−
log

2
=
1.3

, and are divided into gas-rich quenched regions (GRQRs) and gas-poor quenched regions according to the surface density of cold gas (Σgas). Both types of quenched regions tend to be hosted by non-AGN galaxies with relatively high mass (M
* ≳ 1010
M
⊙) and red colors (NUV − r ≳ 3), as well as low star formation rate and high central density at fixed mass. They span wide ranges in other properties including structural parameters that are similar to the parent sample, indicating that the conditions responsible for quenching in gas-rich regions are largely independent of the global properties of galaxies. We train random forest classifiers and regressors for predicting quenching in our sample with 15 local/global properties. Σ* is the most important property for quenching, especially for GRQRs. These results strongly indicate the important roles of low-mass hot evolved stars, which are numerous and long-lived in quenched regions and can provide substantial radiation pressure to support the surrounding gas against gravitational collapse. The different feature importance for quenching, as found previously by A. F. L. Bluck et al., is partly due to the different definitions of quenched regions, particularly the different requirements on EW(Hα).
Dust in Little Red Dots
Authors: Casey Caitlin M. , Akins Hollis B. , Kokorev Vasily , McKinney Jed , Cooper Olivia R. , Long Arianna S. , Franco Maximilien , Manning Sinclaire M. 
Published: October 2024

Abstract
JWST has revealed a ubiquitous population of “little red dots” (LRDs) at z ≳ 4, selected via their red rest-frame optical emission and compact morphologies. They are thought to be reddened by dust, whether in tori of active galactic nuclei (AGNs) or the interstellar medium, though none have direct dust detections to date. Informed by the average characteristics of 675 LRDs drawn from the literature, we provide ballpark constraints on the dust characteristics of the LRD population and estimate they have average dust masses of

〈

M

dust

〉
=
(

1.6

−
0.9

+
4.8

)
×

10

4

M
⊙, luminosities of

〈

L

IR

〉
=
(

8

−
5

+
3

)
×

10

10

L
⊙, and temperatures of

〈

T

dust

〉
=

110

−
36

+
21

K. Notably, the spectral energy distributions are thought to peak at ∼100 K (rest-frame 20–30 μm) regardless of heating mechanism, whether AGN or star formation. LRDs’ compact sizes R
eff ∼ 100 pc are the dominant factor contributing to their low estimated dust masses. Our predictions likely mean LRDs have, on average, a submillimeter emission factor of ∼100× fainter than current Atacama Large Millimeter/submillimeter Array limits provide. The star-to-dust ratio is a factor ∼100× larger than expected from dust formation models if one assumes the rest-optical light is dominated by stars; this suggests stars do not dominate. Despite their high apparent volume density, LRDs contribute negligibly (0.1%) to the cosmic dust budget at z ≳ 4 due to their low dust masses.