bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronotopes in Patrick Modiano’s Fictional Writing of History
Authors: Holm Helge Vidar 
Published: September 2017

The historic heritage that precedes our lives chronologically, such as the experiences of French Jews during the German occupation of their country in World War II, is of fundamental importance to the authorship of Patrick Modiano, born in 1945. Whereas most of his other novels have clearly autobiographical references, Dora Bruder (1997) has a place of its own among Modiano’s novels. In Dora Bruder, the author tries to track the life experiences of a young Jewish girl during the Nazi Occupation of Paris. Buildings, streets and various topoi in Paris and France becomes related to certain experiences of time (chronos) in a narration where Michail Bakhtin’s theories of the chronotope provide an interesting approach to discussing Modiano’s unique form of recreating a traumatic past through fiction.
Nanosized Liposomes Containing Bile Salt: A Vesicular Nanocarrier for Enhancing Oral Bioavailability of BCS Class III Drug
Authors: Arafat Mosab , Kirchhoefer Cathrin , Mikov Momir , Sarfraz Muhammad , Löbenberg Raimar 
Published: September 2017

PURPOSE: Liposomes have been studied as a colloidal carrier in drug delivery systems, especially for oral administration. However, their low structural integrity in the gut is still a major shortcoming. Membrane disruptive effects of physiological bile salts in the small intestine result in premature drug release prior to intestinal absorption. Thus, we analyzed the stabilizing effect of sodium deoxycholate when incorporated into nano-sized liposomes. METHOD: Cefotaxime-loaded liposomes were prepared with different sodium deoxycholate concentrations (3.75- 30 mM) by rotary film evaporation followed by nano-size reduction. The physical integrity of liposomes was evaluated by monitoring cefotaxime leakage, particle sizes in different simulated physiological media. The oral bioavailability and pharmacokinetics of cefotaxime was assessed in rats (n = 6 per group) after single dose of drug-encapsulated in liposomes containing bile salt, drug in conventional liposomes, and cefotaxime solution (oral and intravenous). RESULTS: Simulated gastric fluid with low pH showed less effect on the stability of liposomes in comparison to media containing physiological bile salts. Liposomes containing 15 mM sodium deoxycholate were most stable in size and retained the majority of encapsulated cefotaxime even in fed state of simulated intestinal fluid being the most destructive media. Pharmacokinetics data showed an increase in Cmax and AUC0-inf in the following order: cefotaxime solution < conventional liposomes < liposomes made with bile salts. The total oral bioavailability of cefotaxime in liposomes containing bile salt was found to be 5-times higher compared to cefotaxime solution and twice as much as in conventional liposomes. CONCLUSION: Incorporation of bile salts, initially used as membrane permeation enhancer, also acted as a stabilizer against physiological bile salts. The nano-sized liposomes containing sodium deoxycholate were able to reduce the leakage of encapsulated cefotaxime in the gut due to the improved vesicle stability and to enhance the oral bioavailability of acid-labile drugs up to 5-fold. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
SUSTAINABLE GROWTH RATE AND FIRM PERFORMANCE: A CASE STUDY IN MALAYSIA
Authors: Rahim Norfhadzilahwati 
Published: September 2017

Purpose: Growth for business is significant especially for company’s goal because the company can maintain their performance without running into financial problems. Financial problems or financial distress can make the company not enough capital or financial resources to run company activities. This research investigate the association between firm performance and sustainable growth rate.
Methodology:The indicators for sustainable growth rate are calculated by using Higgins model and the measurements for firm performance such as financial leverage (debt ratio and equity ratio), liquidity (current ratio), and assets efficiency (total asset turnover). The data of the research consists of 226 companies from all sectors except for a financial sector of FBMKLCI Bursa Malaysia over 11 years’ period from 2005 until 2015. This analysis used descriptive method and multiple regression analysis.
Findings:The results found that there is a significant relationship between debt ratio, equity ratio, total asset turnover and size of the firm with sustainable growth rate.
Practical Implications:The sustainable growth rate is one of the valuable financial tools especially for managers used to gauging financial and operating decision, whether to sustain, increase or decrease.
Social Implications: The results of this study also enable the company to manage its financial and operating policy towards healthy growth without having additional financial problem.
Research Limitations/Implications:This study focuses on all sectors except for financial sector of Bursa Malaysia to identify an implication to the role of debt and financing decisions for sustainable firm’s growth over 11 years period from 2005 until 2015.
Originality/Value: Our results are suitable for companies to manage their solid performance to sustain firm’s growth in the future undertakings.
Study of Adsorption Capacity of Dibenzotiofen Molecules on Mesoporous Carbon with Pore Geometry Model
Authors: Ulfa Maria , Fawzia Farhah Nayla 
Published: September 2017

<p>Adsorption models in a simple and accurate way to describe the geometry of the pores have been studied and validated experimentally to predict the adsorption capacity dibenzotiofen molecules on mesoporous carbon. The model is designed according to the size of the pore channels of mesoporous carbon and molecular arrangement dibenzotiofen that goes into the pores. To test the accuracy of the model is done by comparation with results of analysis of nitrogen adsorption-desorption to calculate the volume filled. The results showed that the results of the experimental adsorption data are within the range of values of the pore volume of mesoporous carbon. These results indicate that the pore geometry model molecule can accurately predict the adsorption capacity of a molecule in a mesoporous material.</p><p class="AbstracttitleDERJournal"> </p>
Leveraging electronic medical record data for population health management in the Veterans Health Administration: Successes and lessons learned
Authors: Carmichael Jannet M. , Meier Joy , Robinson Amy , Taylor Janice , Higgins Diana T. , Patel Shardool 
Published: September 2017

Abstract

Purpose
The process and operational elements to establish a population health program using electronic medical record data in a Veterans Health Administration region are described.

Summary
Pharmacists are uniquely qualified to assume important roles in population health through the use of their clinical knowledge, assisted by electronic tools that consolidate and report patient-specific data for clinical care. Veterans Integrated Services Network (VISN) 21 has developed 300 dashboards and reports to improve the quality, safety, and value of healthcare to veterans. Within a group of specialty task forces, physicians, nurses, and pharmacists assist in the design and development of evidence-based tools to leverage timely electronic health information into metrics, benchmarks, and targets to assist with goal achievement. Examples of programs designed to improve care in 3 areas were selected for further description and review of outcomes. Population health improvement using Healthcare Effectiveness Data and Information Set and hepatitis C metrics were used to describe populations that may have an indication for evidence-based care but are not receiving it. Deprescribing efforts are described, as are medication safety monitoring efforts to prevent potential adverse events known to be associated with therapy.

Conclusion
Quality, safety, and value outcomes are the measures of success for population health programs in VISN 21. Data-rich project dashboards and reports are developed by pharmacist data analysts and implemented and used by teams of clinicians who provide continuous feedback and support to improve population health. The use of task forces, metrics, benchmarks, targets, and teams is instrumental in the successful application of these tools.
Life cycle assessment study on polishing units for use of treated wastewater in agricultural reuse
Authors: Büyükkamacı Nurdan , Karaca Gökçe 
Published: September 2017

Abstract
A life cycle assessment (LCA) approach was used in the assessment of environmental impacts of some polishing units for reuse of wastewater treatment plant effluents in agricultural irrigation. These alternative polishing units were assessed: (1) microfiltration and ultraviolet (UV) disinfection, (2) cartridge filter and ultrafiltration (UF), and (3) just UV disinfection. Two different energy sources, electric grid mix and natural gas, were considered to assess the environmental impacts of them. Afterwards, the effluent of each case was evaluated against the criteria required for irrigation of sensitive crops corresponding to Turkey regulations. Evaluation of environmental impacts was carried out with GaBi 6.1 LCA software. The overall conclusion of this study is that higher electricity consumption causes higher environmental effects. The results of the study revealed that cartridge filter and UF in combination with electric grid mix has the largest impact on the environment for almost all impact categories. In general, the most environmentally friendly solution is UV disinfection. The study revealed environmental impacts for three alternatives drawing attention to the importance of the choice of the most appropriate polishing processes and energy sources for reuse applications.
Compartimentos de biomasa aérea en rodales de Pinus oaxacana bajo tratamientos silvícolas
Authors: Chávez-Pascual Edwin Yoshimar , Rodríguez-Ortiz Gerardo , Enríquez-del Valle José Raymundo , Velasco-Velasco Vicente Arturo , Gómez-Cárdenas Martín 
Published: September 2017

Cuantificar la biomasa forestal aérea del bosque es importante para evaluar la productividad y el efecto de sistemas silvícolas aplicados. El objetivo fue generar modelos alométricos para estimar biomasa aérea de Pinus oaxacana y mezcla de especies asociadas en respuesta a tratamientos silvícolas. En Ixtlán, Oaxaca, México, durante 2014 se establecieron 12 unidades experimentales de 400 m2 en rodales sometidos a diferente tratamiento silvícola: 1) sin tratamiento (conservación), 2) árboles padres, con regeneración de 10 años de edad, 3) árboles padres con regeneración de 15 años de edad, 4) matarrasa, con regeneración de siete años de edad. Con datos obtenidos mediante muestreo destructivo (n = 69 individuos) se construyeron modelos alométricos de biomasa de los compartimentos parciales y totales de P. oaxacana, arbustivo, en el piso forestal y sotobosque. En experimento mediante diseño completamente aleatorizado, los datos se sometieron a análisis de varianza, prueba de separación de medias (Duncan, 0.05), análisis clúster y modelos de regresión. Los modelos que utilizan variables de fácil medición, estiman entre 88% y 98% de la biomasa aérea de individuos de porte arbóreo y arbustivo de P. oaxacana y especies arbustivas asociadas. Los tratamientos silvícolas aplicados afectaron (p ≤ 0.05) la biomasa aérea acumulada en los compartimentos específicos y totales de P. oaxacana, así como la biomasa contenida en el piso forestal, sotobosque y total aéreo. Sin embargo, los rodales manejados bajo tratamientos de árboles padres (101.3 t ha-1) igualan la productividad de biomasa total aérea que el bosque bajo conservación (125.74 t ha-1).
Effect of Sofosbuvir-Based Hepatitis C Virus Therapy on Kidney Function in Patients with CKD
Authors: Sise Meghan E. , Backman Elke , Ortiz Guillermo A. , Hundemer Gregory L. , Ufere Nneka N. , Chute Donald F. , Brancale Joseph , Xu Dihua , Wisocky Jessica , Lin Ming V. , Kim Arthur Y. , Thadhani Ravi , Chung Raymond T. 
Published: September 2017

Background and objectives
Hepatitis C virus infection is common in patients with CKD and leads to accelerated progression to ESRD. Sofosbuvir is a potent direct-acting antiviral therapy against hepatitis C virus; however, there are concerns about its safety in patients with CKD. The objective of our study was to determine the safety and efficacy of sofosbuvir in patients with CKD.

Design, setting, participants, & measurements
We studied a retrospective observational cohort of patients with CKD defined by eGFR<60 ml/min per 1.73 m2, ≥30 mg albuminuria per 1 g creatinine, or ≥200 mg proteinuria per 1 g creatinine who received sofosbuvir-based therapy in a large health care system. Regression models were constructed to predict likelihood of sustained virologic response, detect adverse events, and examine changes in eGFR from baseline to follow-up.

Results
Ninety-eight patients with CKD (42% stage 1 or 2 CKD and 58% stage 3 CKD) were included. Mean age was 62 years old, 78% were men, and 65% were white. Additionally, 49% of patients had diabetes, 38% of patients had cirrhosis, and 33% of patients had prior solid organ transplant. Overall sustained virologic response was 81% and varied by regimen used and viral genotype. Average baseline eGFR was equivalent to average on-treatment eGFR, but seven patients experienced a rise in creatinine ≥1.5 times baseline while taking sofosbuvir; all but one recovered. In patients with eGFR<60 ml/min per 1.73 m2 at baseline (stage 3 CKD), regression models showed that hepatitis C cure was associated with a 9.3 (95% confidence interval, 0.44 to 18) ml/min per 1.73 m2 improvement in eGFR during the 6-month post-treatment follow-up period. Adverse events were common (81%), but serious adverse events (17%) and treatment discontinuations (8%) were uncommon.

Conclusions
Sofosbuvir-based direct-acting antiviral therapy is safe and effective in a cohort of patients with CKD infected with hepatitis C.
A SysML based hybrib photovoltaic-wind power system model
Authors: Luta Doudou Nanitamo , Raji Atanda K. 
Published: September 2017

This paper presents a model of hybrid photovoltaic-wind power system based on SysML (System Modeling Language) which is a modeling language in supports to Model Based Systems Engineering (MBSE) practices. MBSE refers to a formalized procedure of systems development through the application of modeling principles, methods, languages and tools to the complete lifetime of a system. Broadly speaking, the modeling of power systems is performed using software such as Matlab/Simulink, DigSilent, PowerWorld, ETAP, etc. These tools allow modeling considering a particular point of view depending on the objective that is to be assessed. SysML offers different aspects ranging from specifications and requirements, structure and behavior. This study focuses more specifically on the structural and behavioral modeling of hybrid photovoltaic-wind system; the main objective is to demonstrate the use of SysML in power systems’ modeling by developing models capturing the system’s major requirements, the structure and connection between entities, the interaction between stakeholders and the system itself and lastly, the system’s behavior in terms of transition between states.
Caracterizaciòn de la fonética y escritura de la letra “A” en señales cerebrales usando transformada wavelet
Authors: Portilla González German Arley , Luis Enrique Mendoza Luis Enrique Mendoza , Thomas M Saury 
Published: September 2017

La afasia motriz afecta únicamente el lenguaje, y el área cognitiva queda intacta, esta falla cerebral se presenta sobre el área de broca, donde se manejan los impulsos aferentes de la articulación y modulación del lenguaje. Este trabajo muestra la obtención usando wavelet de patrones característicos de señales encefalografías provenientes de: fonética y escritura de la letra A, esto permitirá en un futuro tener una alternativa de comunicación distinta a pronunciar palabras. Este trabajo se presenta debido a las gran cantidad accidentes cerebrovasculares que afectan la capacidad de dialogo. Mediante la toma de señales electroencefalografías (SEEG) en puntos específicos se puede lograr caracterizar procesos de: gesticulación e interpretación de letras. El estudio se aplicó sobre 10 sujetos con edades de 24 y 25 años, la toma fue en condiciones similares en estado de vigilia. Se registraron 20 señales de la letra pronunciada, 20 de la letra escrita y 5 del sujeto en reposo. Se demostró que existen patrones diferentes que caracterizan la pronunciación y escritura de la letra “A” en una representación de SEEG.
The addition of duraplasty to posterior fossa decompression in the surgical treatment of pediatric Chiari malformation Type I: a systematic review and meta-analysis of surgical and performance outcomes
Authors: Lu Victor M. , Phan Kevin , Crowley Sean P. , Daniels David J. 
Published: September 2017

OBJECTIVESurgery is the definitive treatment of Chiari malformation Type I (CM-I). It involves posterior fossa decompression, which can be performed along with C-1 laminectomy, reconstructive duraplasty, or tonsil shrinkage. The aim of this study was to provide an updated systematic review and meta-analysis of the latest available evidence regarding posterior fossa decompression only (PFDO) versus posterior fossa decompression with duraplasty (PFDD) in the treatment of CM-I in children.METHODSA literature search was performed in compliance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for article identification, screening, eligibility, and inclusion. Relevant articles were identified from 6 electronic databases from their inception to April 2016. These articles were screened against established criteria for inclusion into this study.RESULTSFrom 12 relevant studies identified, 1492 pediatric patients treated via PFDD were compared with 1963 pediatric patients treated by PFDO for CM-I. PFDD was associated with greater overall clinical improvement (p = 0.009), along with longer length of stay (p < 0.0001) and more postoperative complications (p = 0.0001) compared with PFDO. No difference was observed between PFDD and PFDO in terms of revision surgery incidence (p = 0.13), estimated blood loss (p = 0.14), syrinx improvement (p = 0.09), or scoliosis improvement (p = 0.95).CONCLUSIONSIt appears that the addition of duraplasty to posterior decompression in the definitive treatment of CM-I in children may alter surgical and performance outcomes. In particular, parameters of overall clinical improvement, length of stay, and postoperative complication may differ between children undergoing PFDD and those undergoing PFDO. Current evidence in the literature is of low to very low quality that, as of yet, has not been able to completely control for inherent selection bias both in study design and surgeon preference. Future, large prospective registries and randomized controlled trials are warranted to validate the findings of this study.
Inner Asian Pastoralism in the Iron Age: The Talgar Case, South-Eastern Kazakhstan
Authors: Chang Claudia 
Published: September 2017

Abstract
The romantic image of the fierce Iron Age horse-riding pastoralists of the first millennium BC who roamed the Eurasian steppe has dominated our historical imagination of nomadic confederacies. The Scythians, Saka, Sarmatians, Wusun and Yuezhi, when described by ancient Greek historians and Chinese chroniclers, have been identified as the 'barbarians' (Beckwith 2009). In such accounts these nomadic barbarians occupied the 'edges' or peripheries of core agrarian states. In this article I explore how the Iron Age archaeology of settlements and burial mounds (kurgans) of a remote area along the Tian Shan Mountains of south-eastern Kazakhstan provides a different picture of the so-called barbarians. In order to build an archaeological case that allows for a different interpretation of the formation and evolution of Iron Age agro-pastoralism at the southern edge of the Eurasian steppe, this story must be told through the lens of a field archaeologist.
10,000 Years of Pastoralism in Anatolia: A Review of Evidence for Variability in Pastoral Lifeways
Authors: Hammer Emily Louise , Arbuckle Benjamin S. 
Published: September 2017

Abstract
Archaeological and historical data show that pastoral systems in Anatolia over the last ten thousand years were characterised by a high degree of variability in degree of mobility, land-use and animal preferences, target products and herd management strategies, and political organisation. Long-distance pastoral nomadism was a historically late development in the region, occurring over the last 1,500 to 1,000 years. Ethnographic analogy currently structures the majority of archaeological conclusions concerning pre-modern pastoralism, but obscures the variability that recent archaeological work brings to light. Multi-disciplinary studies seeking empirical data on ancient pastoralism and mobility are critical for developing a more subtle and accurate picture.
Botkhane Cave: New Evidence from Nomadic and Semi-Sedentary Communities in the Central Zagros During the Late Chalcolithic Period and the Bronze Age: Kuhdasht, Luristan, Iran
Authors: Niknami Kamal Aldin , Mirghaderi Mohammad Amin , Garavand Morteza 
Published: September 2017

Abstract
Years of investigation, of varying degrees, have been undertaken into the semi- sedentary communities in the Near East and especially central Zagros, encompassing ethnology, anthropology and ethno-archaeology. All this research provides useful information regarding the cultural structure of the semi-sedentary communities of central Zagros. However, due to the difficulties in identifying the sites related to this type of livelihood, reconstructing such cultural structures is problematic; thus special strategies are required in archaeological excavation and surveys. Meanwhile, caves and rock shelters preserve some evidence of ancient settlements and can enhance our knowledge about their livelihood patterns and cultural structures. Identifying these settlements is evidently easier than finding settlements in open spaces as they incurred less damage than open sites. Botkhane cave is one of this group of settlements, which reflects various aspects of the semi-sedentary communities' cultural structure in central Zagros.
This cave is located 21 kilometres southeast of Kuhdasht city and one kilometre east of Damchehr Qaralivand village in the west of Luristan province. Evidence of settlements from the fourth millennium bc into the historic period have been revealed in this cave during a threat mitigation plan in 2008. Numerous bone remains of humans, goats, horses, rabbits etc. have also been observed. Although the cultural materials in this cave have been displaced, making the stratigraphy process impossible, due to the importance of the discoveries and the strategic location of the cave, all the finds have been collected and documented. The present study aims to introduce the cave's cultural materials and the remains' relative chronology, along with an analytical overview of the cave's function, based on the existing evidence, from the second half of the fourth millennium bc to the end of the Bronze Age.