bluuebunny/crossref_metadata_2025_split huggingface dataset:
NO Augments Endothelial Reactivity by Reducing Myoendothelial Calcium Signal Spreading
Authors: Pogoda Kristin , Mannell Hanna , Blodow Stephanie , Schneider Holger , Schubert Kai Michael , Qiu Jiehua , Schmidt Andreas , Imhof Axel , Beck Heike , Tanase Laurentia Irina , Pfeifer Alexander , Pohl Ulrich , Kameritsch Petra 
Published: October 2017

Objective—
Because of its strategic position between endothelial and smooth muscle cells in microvessels, Cx37 (Connexin 37) plays an important role in myoendothelial gap junctional intercellular communication. We have shown before that NO inhibits gap junctional intercellular communication through gap junctions containing Cx37. However, the underlying mechanism is not yet identified.

Approach and Results—
Using channel-forming Cx37 mutants exhibiting partial deletions or amino acid exchanges in their C-terminal loops, we now show that the phosphorylation state of a tyrosine residue at position 332 (Y332) in the C-terminus of Cx37 controls the gap junction–dependent spread of calcium signals. Mass spectra revealed that NO protects Cx37 from dephosphorylation at Y332 by inhibition of the protein tyrosine phosphatase SHP-2. Functionally, the inhibition of gap junctional intercellular communication by NO decreased the spread of the calcium signal (induced by mechanical stimulation of individual endothelial cells) from endothelial to smooth muscle cells in intact vessels, while, at the same time, augmenting the calcium signal spreading within the endothelium. Consequently, preincubation of small resistance arteries with exogenous NO enhanced the endothelium-dependent dilator response to acetylcholine in spite of a pharmacological blockade of NO-dependent cGMP formation by the soluable guanylyl cyclase inhibitor ODQ (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one).

Conclusions—
Our results identify a novel mechanism by which NO can increase the efficacy of calcium, rising vasoactive agonists in the microvascular endothelium.
Uncoupling Protein 2 Inhibits Myointimal Hyperplasia in Preclinical Animal Models of Vascular Injury
Authors: Zhang Yan , Zhang Yaolei , Li Wei , Wang Peijian , Gu Rui , Feng Yaxing , Wei Shujie , Peng Ke , Zhang Yunrong , Su Linan , Wang Qiang , Li De , Yang Dachun , Wong Wing Tak , Yang Yongjian , Ma Shuangtao 
Published: October 2017

Background
Intracoronary stent restenosis, characterized by excessive smooth muscle cell (SMC) proliferation and myointimal hyperplasia, remains a clinical challenge. Mitochondrial membrane potential has been linked to the proliferative rate of SMCs. This study aimed to screen a critical gene regulating mitochondrial potential and to confirm its effects on myointimal formation in preclinical animal models.

Methods and Results

We performed transcriptome screening for genes differentially expressed in ligated versus unligated mouse carotid arteries. We observed that uncoupling protein 2 gene (
Ucp2
) mRNA, encoding UCP2, was transiently upregulated during the first 3 days after ligation and then significantly downregulated from day 7 through day 21, during which time neointima formed remarkably. The UCP2 protein level also declined after day 7 of ligation. In ligated carotid arteries,
Ucp2
−/−
mice, compared with wild‐type littermates, exhibited accelerated myointimal formation, which was associated with increased superoxide production and can be attenuated by treatment with antioxidant 4‐hydroxy‐2,2,6,6‐tetramethyl‐piperidinoxyl (TEMPOL). Knockdown of UCP2 enhanced human aortic SMC migration and proliferation that can also be attenuated by TEMPOL, whereas UCP2 overexpression inhibited SMC migration and proliferation, along with decreased activity of nuclear factor‐κB. Moreover, nuclear factor‐κB inhibitor attenuated UCP2 knockdown‐enhanced SMC proliferation. Adenovirus‐mediated overexpression of UCP2 inhibited myointimal formation in balloon‐injured carotid arteries of rats and rabbits and in‐stent stenosis of porcine coronary arteries. Moreover, UCP2 overexpression also suppressed neointimal hyperplasia in cultured human saphenous vein ex vivo.

Conclusions
UCP2 inhibits myointimal hyperplasia after vascular injury, probably through suppressing nuclear factor‐κB–dependent SMC proliferation and migration, rendering UCP2 a potential therapeutic target against restenosis.
Interpreting the Warring States Graphs Zi 才 and Chui in Light of the Yancang Chu Slips (由嚴倉楚簡看戰國文字資料 中“才”、“”兩字的釋讀)
Authors: Tianhong (李天虹) Li 
Published: October 2017

Scholars have previously suggested that the characters 才 and in a variety of published Warring States texts may be interpreted as fractions: 才 has been read as zi 錙, meaning “one fourth”; has been read as chui 錘, meaning “one third.” The Yancang Chu slips, excavated in 2010 but not yet published, contain a number of similar uses of these graphs that more fully substantiate these readings as fractions. How the graphs originally came to be used as fractions awaits further research.
已公佈戰國文字資料中散見用作數詞的“才”字和“”字，有學者認爲“才”應當讀爲“錙”，表示四分之一；“”應當讀爲“錘”，表示三分之一。2010年出土、尚未公布的嚴倉楚簡中，多見相同用法的“才”和“”，爲此説提供了比較豐富的例證。錙、錘何以有這種用法，尚有待進一步探討。
An Overview of Western Sinologists’ Studies of Chinese Paleography (西方漢學家中國古文字研究概要)
Authors: Shaughnessy (夏含夷) Edward L. 
Published: October 2017

This essay, the first chapter in the author’sXifang Hanxue chutu wenxian yanjiu gaiyao西方漢學出土文獻研究概要 (Essentials of Western Sinology’s Research on Unearthed Documents), provides a survey of Western Sinology’s research on Chinese paleography from the time of the first such study (1881) through 2015. The survey includes especially the following topics: general discussions of Chinese paleography and/or unearthed documents, the origins of Chinese writing and its social functions, the nature of Chinese writing, methodological studies, and reference works, but does not cover studies of ancient Chinese grammar or phonology.摘要這篇文章是作者著《西方漢學出土文獻研究概要》第一章，就 1881 年到 2015年間西方漢學對中國出土文獻與古文字研究成果作概括的論述，分成下列題目：中國出土文獻與古文字學綜論、中國文字的起源及其社會作用、中國文字的性質、古文字學方法論、古文字學參考書，但是不包括相關的古代漢語語法研究和古代漢語音韻學。
The Effects of Recovery-Oriented Cognitive–Behavior Approach for Chinese With Severe Mental Illness
Authors: Wong Daniel F. K. , Chan Viola , Ip Priscilla , Zhuang Xiao Yu 
Published: October 2017

Purpose: Hope and meaning in life are essential components of personal growth and happiness. Built on the recovery model, this study attempted to evaluate the effects of a recovery-oriented cognitive–behavior approach (CBA) in enhancing hope and meaning in life among a group of people with severe mental illness in Hong Kong. Method: A matched-pair comparison approach was adopted. Twenty-seven experimental group participants received recovery-oriented CBA, while 25 participants received standard counseling services. Assessments were administered at preintervention and at 6 and 12 months of intervention. Results: Repeated measures analyses of covariance indicated that the recovery-oriented CBA was more effective than the control condition in improving the mental health recovery process (basic functioning, finding new potentials, and spirituality) and a sense of hope (planning in achieving goals). Conclusion: Given these initial positive results, more vigorous studies and refinement of this recovery-oriented CBA are needed to ascertain the effectiveness of this combined intervention approach.
Efficacy of itraconazole oral solution using an alternating-week pulse therapy regimen for treatment of cats with experimental Microsporum canis infection
Authors: Puls Christopher , Johnson Aaron , Young Karrie , Hare Jonathan , Rosenkrans Kelly , Young Lisa , Moriello Karen 
Published: October 2017

Objectives The objective of this study was to evaluate itraconazole 10 mg/ml oral solution for the treatment of Microsporum canis infection using an alternating-week pulse therapy regimen in a controlled laboratory setting. Methods Eighty cats with experimentally induced infections were randomly assigned to treatment (itraconazole vs control [sterile water]), administered 5 mg/kg PO q24h for 1 week on alternate weeks for 5 weeks, followed by a 4 week follow-up period. Topical therapeutic treatment was not administered. Cats were individually housed in stainless steel cages that were cleaned and disinfected daily. Study measures included weekly fungal cultures, clinical lesion scores, Wood’s lamp examination and periodic laboratory monitoring. Mycological cure was defined as two consecutive negative cultures. Results Itraconazole-treated cats had significantly greater ( P = 0.0003) mycological cure compared with untreated controls (24/40 [60%] vs 1/40 [2.5%], respectively) and all of these reached clinical cure and had negative final Wood’s lamp examinations. Furthermore, 36/40 (90%) treated cats had at least one negative fungal culture by the end of the study vs only 3/40 (7.5%) control cats. For both treatment groups, prevalence of clinical cure peaked at the end of the study (week 9), with 39/40 (97.5%) itraconazole-treated cats and 6/40 (15%) control cats achieving clinical cure. Wood’s lamp negative examination rates were significantly greater ( P <0.0001) for itraconazole-treated cats compared with controls (39/40 cats [97.5%] vs 6/40 [15%], respectively) and followed the same pattern of improvement as primary clinical lesions. Conclusions and relevance In this controlled study, orally administered itraconazole using a 5 mg/kg pulse-dose treatment regimen reduced the time to mycological cure and increased both mycological and clinical cure rates compared with untreated controls.
Clinical Outcomes Following an Open Gastrocnemius Recession Combined With an Endoscopic Plantar Fasciotomy
Authors: Mulhern Jennifer L. , Protzman Nicole M. , Summers N. Jake , Brigido Stephen A. 
Published: October 2017

At present, there is a paucity of literature describing the clinical outcomes following a combined gastrocnemius recession and endoscopic plantar fasciotomy. The purpose of the present report is to describe our preliminary findings following a combined gastrocnemius recession and endoscopic plantar fasciotomy for the treatment of plantar fasciitis and gastrocnemius equinus recalcitrant to conservative therapy. Twenty-five consecutive ankles in 23 patients (age 51.2 ± 12.5 years, 4 men) met the inclusion and exclusion criteria. The average follow-up was 3.7 months. Compared across time, there were statistically significant improvements in pain, t(24) = 7.878, P < .001; dorsiflexion, t(24) = −6.125, P < .001; and eversion, t(23) = −3.610, P = .001. Plantar flexion and inversion remained similar across time ( P = .722 and P = .268, respectively). No statistically significant correlations were found between age and any of the postoperative outcome variables ( P ≥ .056) or body mass index and any of the postoperative outcome variables ( P ≥ .140). The authors believe that an isolated plantar fasciotomy alleviates symptoms in the majority of patients. When gastrocnemius equinus is also present, however, the authors advocate performing an open gastrocnemius recession as well. If the gastrocnemius pathology is not addressed, symptoms are likely to persist. The findings of the present report confirm the effectiveness of a combined gastrocnemius recession and endoscopic plantar fasciotomy to improve pain and range of motion. Levels of Evidence: Case series, Level IV: Retrospective
Race–Crime Congruency Effects Revisited: Do We Take Defendants' Sexual Orientation Into Account?
Authors: Petsko Christopher D. , Bodenhausen Galen V. 
Published: October 2017

Decades ago, social psychologists documented a juror decision-making bias called the race–crime congruency effect: a tendency to condemn Black men more than White men for stereotypically Black crimes but to do the reverse for stereotypically White crimes. We conducted two high-powered experiments ( N = 2,520) to see whether this pattern replicates and to examine whether it is attenuated when the defendant is gay. When participants reported on what the average American juror would do (Experiment 1), we observed greater harshness toward Black defendants accused of stereotypically Black crimes but not the previously documented reversal for stereotypically White crimes. Defendant sexual orientation did not moderate this pattern. When participants reported their own judgments about the same criminal cases (Experiment 2), they expressed greater harshness toward White (vs. Black) defendants and toward heterosexual (vs. gay) defendants. These effects were not moderated by crime type. Implications for the race–crime congruency effect are discussed.
Diffusion tensor tractography in cerebral small vessel disease: correlation with cognitive function
Authors: D’Souza Maria M , Gorthi SP , Vadwala Kunal , Trivedi Richa , Vijayakumar C , Kaur Prabhjot , Khushu Subash 
Published: October 2017

Background Patients with cerebral small vessel disease may suffer from varying levels of cognitive deficit and may progress on to vascular dementia. The extent of involvement, as seen on conventional magnetic resonance (MR) measures, correlates poorly with the level of cognitive decline. The purpose of this study was to investigate the utility of diffusion tensor imaging (DTI) as a marker for white matter damage in small vessel disease and to assess its correlation with cognitive function. Methods Thirty consecutive patients with cerebral small vessel disease underwent conventional MR imaging, DTI, and neuropsychological assessment. Results On tractographic analysis, fractional anisotropy was significantly reduced while mean diffusivity significantly increased in several white matter tracts. The alteration in DTI indices correlated well with cognitive function. No significant correlation was identified between T2 lesion load and cognitive performance. Conclusions Tractographic analysis of white matter integrity is a useful measure of disease severity and correlates well with cognitive function. It may have a significant potential in monitoring disease progression and may serve as a surrogate marker for treatment trials.
Clinical Outcomes of Donor Sites After Osteochondral Graft Harvest From Healthy Knees
Authors: Nakagawa Yasuaki , Mukai Shogo , Setoguchi Yoshimasa , Goto Tadashi , Furukawa Taizo , Nakamura Takashi 
Published: October 2017

Background: The use of autologous osteochondral grafts has become popular in the treatment of small, isolated, well-contained articular cartilage defects. However, donor site morbidity is a problem, and few reports are available of donor site morbidity after mosaicplasty. Purpose: To examine the clinical outcomes of donor sites after osteochondral grafts from healthy knees. Study Design: Case series; Level of evidence, 4. Methods: Between September 1997 and September 2011, there were 40 patients (40 knees; 32 men, 8 women; 31 right knees, 9 left knees) with asymptomatic osteochondral graft donor sites used for autologous transfer; all had a follow-up period of >2 years. The mean patient age at surgery was 21.0 years (range, 12-58 years). The recipient sites included the elbow (n = 28), contralateral knee (n = 5), and ankle (n = 7). The mean diameter of the grafted plugs was 7.5 mm (range, 4.5-9 mm), and the mean number of grafted plugs was 2.2 (range, 1-3). At a mean follow-up of 43.1 months (range, 24-177 months), knee symptoms, return to sport, ability to sit straight in Japanese style, and radiological changes of the patellofemoral joint were evaluated. Whether operative age, follow-up period, and diameter or number of the grafted plugs were risk factors was analyzed statistically. Significance was defined as P < .05. Results: Thirty-four patients had no knee symptoms, and 4 patients had occasional mild knee pain. Two patients underwent reoperation for arthrofibrosis and not for cartilage defect. Twenty-seven patients had complete return to sports, and 32 patients could sit straight; donor site morbidity was not the cause of failure to return to sports or inability to sit straight. The radiological changes became worse in 3 patients, and the risk factor for degenerative change was older operative age. Conclusion: When osteochondral plugs were obtained from healthy knees, 34 patients (85%) were asymptomatic at follow-up. No donor site defects required surgical intervention due to persistent symptoms.
Depression, quality of life, and medical resource utilization in sickle cell disease
Authors: Adam Soheir S. , Flahiff Charlene M. , Kamble Shital , Telen Marilyn J. , Reed Shelby D. , De Castro Laura M. 
Published: October 2017

Key PointsDepression was found in 35.2% of adult SCD patients and was strongly associated with worse physical and mental quality-of-life outcomes. Total health care costs for adult SCD patients with depression were more than double those of SCD patients without depression.
A 3D localisation method in indoor environments for virtual reality applications
Authors: Song Wei , Liu Liying , Tian Yifei , Sun Guodong , Fong Simon , Cho Kyungeun 
Published: October 2017

AbstractVirtual Reality (VR) has recently experienced rapid development for human–computer interactions. Users wearing VR headsets gain an immersive experience when interacting with a 3-dimensional (3D) world. We utilise a light detection and ranging (LiDAR) sensor to detect a 3D point cloud from the real world. To match the scale between a virtual environment and a user’s real world, this paper develops a boundary wall detection method using the Hough transform algorithm. A connected-component-labelling (CCL) algorithm is applied to classify the Hough space into several distinguishable blocks that are segmented using a threshold. The four largest peaks among the segmented blocks are extracted as the parameters of the wall plane. The virtual environment is scaled to the size of the real environment. In order to synchronise the position of the user and his/her avatar in the virtual world, a wireless Kinect network is proposed for user localisation. Multiple Kinects are mounted in an indoor environment to sense the user’s information from different viewpoints. The proposed method supports the omnidirectional detection of the user’s position and gestures. To verify the performance of our proposed system, we developed a VR game using several Kinects and a Samsung Gear VR device.
Complete genome sequence of Paenibacillus yonginensis DCY84T, a novel plant Symbiont that promotes growth via induced systemic resistance
Authors: Kim Yeon-Ju , Sukweenadhi Johan , Seok Ji Woong , Kang Chang Ho , Choi Eul-Su , Subramaniyam Sathiyamoorthy , Yang Deok Chun 
Published: October 2017

AbstractThis article reports the full genome sequence of Paenibacillus yonginensis DCY84T (KCTC33428, JCM19885), which is a Gram-positive rod-shaped bacterium isolated from humus soil of Yongin Forest in Gyeonggi Province, South Korea. The genome sequence of strain DCY84T provides greater understanding of the Paenibacillus species for practical use. This bacterium displays plant growth promotion via induced systemic resistance of abiotic stresses.
Updated mtCOI reference dataset for the Bemisia tabaci species complex
Authors: Boykin Laura M. , Savill Anders , De Barro Paul 
Published: October 2017

Members of the whitefly Bemisia tabaci species complex cause millions of dollars of damage globally and are considered one of the world’s most invasive species. They are capable of causing extensive damage to major vegetable, grain legume and fiber crops. All member of the species complex are morphologically identical therefore, data from the partial mitochondrial cytochrome oxidase subunit I (mtCOI) gene sequence has been used to identify the various species. The current reference dataset that is widely used is found on the CSIRO data portal. However, the reference set stored on the CSIRO data does not include newly added sequences (2013-2017), therefore an updated reference dataset is needed. All mtCOI data for the Bemisia tabaci species complex were downloaded on 22 May 2017 from GenBank and after quality checking, a dataset of 1,071 unique sequences and 696 base pairs was generated (https://doi.org/10.6084/m9.figshare.5437420.v1).
­­­Proteomic analysis of H3K36me3 and PSIP1/p75 (LEDGF) complexes reveal their wider role in DNA repair
Authors: Pradeepa Madapura M. , Taylor Gillian C.A. , von Kriegsheim Alex 
Published: October 2017

Background: Trimethylation at histone H3 at lysine 36 (H3K36me3) is associated with expressed gene bodies and recruit proteins implicated in transcription, splicing and DNA repair. PC4 and SF2 interacting protein (PSIP1/LEDGF) is a transcriptional coactivator, possesses a H3K36me3 reader PWWP domain. Alternatively spliced isoforms of PSIP1 binds to H3K36me3 and suggested to function as adaptor proteins to recruit transcriptional modulators, splicing factors and proteins that promote homology directed repair (HDR), to H3K36me3 chromatin. Methods: We performed chromatin immunoprecipitation of H3K36me3 followed by quantitative mass spectrometry to identify proteins associated with H3K36 trimethylated chromatin in mouse embryonic stem cells (mESCs). Furthermore, we performed stable isotope labelling with amino acids in cell culture (SILAC) for a longer isoform of PSIP1 (p75) and MOF/KAT8 in mESCs and mouse embryonic fibroblasts (MEFS). Results: Proteomic analysis of H3K36me3 chromatin show association of proteins involved in transcriptional elongation, RNA processing and DNA repair with H3K36me3 chromatin. Furthermore, we show DNA repair proteins like PARP1, gamma H2A.X, XRCC1, DNA ligase 3, SPT16, Topoisomerases and BAZ1B are predominant interacting partners of PSIP1/p75. We validated the association of PSIP1/p75 with gamma H2A.X, an early marker of DNA damage and also demonstrated accumulation of damaged DNA in PSIP1 knockout MEFs. Conclusions: In contrast to the previously demonstrated role of H3K36me3 and PSIP1/p75 in promoting HDR in mammals, our data supports the wider role of H3K36me3 and PSIP1 in maintaining the genome integrity by recruiting several DNA repair proteins to transcribed gene bodies.
The Three-Factor Eating Questionnaire-R18 Polish version: factor structure analysis among normal weight and obese adult women
Authors: Brytek-Matera Anna , Rogoza Radosław , Czepczor-Bernat Kamila 
Published: October 2017

Aim of the studyIn the present study, we aimed to examine the construct validity of the Three-Factor Eating Questionnaire-R18 (TFEQ-R18) and to investigate variables of the following phenomena such as cognitive restraint, uncontrolled eating and emotional eating in normal weight women and women with obesity.Subject or material and methodsThe research sample comprised 237 participants (200 with normal weight and 37 obese): the Three-Factor Eating Questionnaire-R18 was distributed to all participants at the same time.ResultsWe have found that the three-factor structure is invariant at each level— configural, metric, scalar, and strict. Individuals with obesity scored significantly higher than individuals within normal weight range in uncontrolled eating (p = .005) and emotional eating (p = .053).DiscussionObserved ambiguities between the results provided by the current and other studies may be explained in terms of the controlling of the shared variance and measurement error, since only up to date summarized scores were compared across groups.ConclusionsThese results broaden knowledge of eating behaviours in normal weight individuals as well as those with obesity.
New approach to the resolution of triangular fuzzy linear programs: MOMA-plus method.
Authors: COMPAORE Abdoulaye , SOME Kounhinir , SOME Blaise 
Published: October 2017

In this paper, we propose a new approach to the resolution of linear programs, whose coefficients are fuzzy triangular numbers. This new approach is an adaptation from the method MOMA-plus (Multi-Objective Metaheuristic based on Alienor method) [1] to the resolution of fuzzy linear programs. First of all it consists in using of a new procedure proposed here to the converting of the fuzzy linear program into a deterministic multi-objective linear program, secondly of the using of the MOMA-plus procedure for resolution. Finally, three numerical examples are given to explain the procedures and highlight the performances of this new approach.