bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coping with the (interactive) environment: The performative potential of interactivity
Authors: Hawksley Sue 
Published: June 2016

Abstract
This article explores the performative implications of coping with interactive performance environments, and ways in which such environments may be considered to ‘make’ people. Performers often practice for long durations in information-intensive technologized immersive settings, which demand and develop a combination of spread attentiveness, deep awareness and fast response times. This particular combination of embodied, embedded, durational and attentionally rich experience may prime the brain’s neuroplasticity – the capacity to reorganize its structure and function by forming new neural connections. This is discussed in relation to movement practices, body and self-image, and debate about technogenesis – the idea that humans are defined by their coevolution with technologies. The article considers two interactive works, Garry Stewart’s Proximity (2012) made for Australian Dance Theatre (ADT), and Crosstalk (2014), a collaborative work by artist Simon Biggs, choreographer Sue Hawksley and composer Garth Paine.
From representation to relationality: Bodies, biosensors and mediated environments
Authors: Naccarato Teoma Jackson , MacCallum John 
Published: June 2016

Abstract
In this article we propose a biorelational framework for performance with biosensors, in which interactions are not based on causality, control, and representation, but rather, manifest through shared awareness and agency across multiple, fluid assemblies of self, other and environment. The transdisciplinary scope of this study traces trajectories from the performing and somatic arts into philosophy, biomedicine, cognitive science and human-computer interaction. A brief survey of common approaches to interaction design with biosensors will contextualize discussion of our current practice-based research and creation project, ‘Choreography and Composition of Internal Time’. In this project, we are examining temporal relationships between physiological processes, such as heart rate and breath, with rhythms in movement, music and mediated environments.
Optimized genotyping method for identification of bacterial contaminants in pharmaceutical industry
Authors: Stamatoski Borche , Ilievska Miroslava , Babunovska Hristina , Sekulovski Nikola , Panov Sasho 
Published: June 2016

Abstract
Microbiological control is of crucial importance in the pharmaceutical industry regarding the possible bacterial contamination of the environment, water, raw materials and finished products. Molecular identification of bacterial contaminants based on DNA sequencing of the hypervariable 16SrRNA gene has been introduced recently. The aim of this study is to investigate the suitability of gene sequencing using our selection of PCR primers and conditions for rapid and accurate bacterial identification in pharmaceutical industry quality control.
DNA was extracted from overnight incubated colonies from 10 bacterial ATCC strains, which are common contaminants in the pharmaceutical industry. A region of bacterial 16SrRNA gene was analyzed by bidirectional DNA sequencing. Bacterial identification based on partial sequencing of the 16SrRNA gene is the appropriate method that could be used in the pharmaceutical industry after adequate validations. We have successfully identified all tested bacteria with more than 99 % similarity to the already published sequences.
The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via the spray freeze drying process
Authors: Poursina Narges , Vatanara Alireza , Rouini Mohammad Reza , Gilani Kambiz , Najafabadi Abdolhossein Rouholamini 
Published: June 2016

Abstract
Spray freeze drying was developed to produce dry powders suitable for applications such as inhalation delivery. In the current study, the spray freeze drying technique was employed to produce inhalable salmon calcitonin microparticles. Effects of the carrier type, concentration of hydroxyl propyl-β-cyclodextrin and the presence of Tween 80 on the chemical and structural stability, as well as on the aerosol performance of the particles were investigated. The results indicated that hydroxyl propyl-β-cyclodextrin had the most important effect on the chemical stability of the powder and strongly increased its stability by increasing its concentration in the formulation. Chemically stable formulations (over 90 % recovery) were selected for further examinations. Fluorescence spectroscopy and circular dichroism suggested that the formulations were structurally stable. Aerosol performance showed that the Tween-free powders produced higher fine particle fraction values than the formulations containing Tween (53.7 vs. 41.92 % for trehalose content and 52.85 vs. 43.06 % for maltose content).
Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes
Authors: Sabadková Dana , Franc Aleš , Muselík Jan , Neumann David 
Published: June 2016

Abstract
Patients tend to prevent hypoglycemia by excessive saccharide intake leading to poorer glycemic control with potentially fatal consequences. This problem could be resolved by means of pellets with glucose release delayed by 120–360 min as a compensation of the antidiabetic drug peak effect. No glucose is released before; hence there is no risk of hyperglycemia and secondary complications. The pellets contain glucose in combination with an osmotically active ingredient and are coated with an ethylcellulose dispersion, which forms an insoluble semipermeable membrane and ensures delayed release. The release of glucose was assessed using dissolution and high-performance liquid chromatography. Dissolution profiles indicated the possibility of achieving the requested lag time using a combination of adequate compositions and coating concentrations. Lag times of 60, 240 and 360 min were achieved. The sample containing carboxymethyl starch was found to be most suitable for the intent of this work.
Release of selected amino acids from zinc carriers
Authors: Dyja Renata , Dolińska Barbara , Ryszka Florian 
Published: June 2016

Abstract
The paper deals with the results of an investigation of the release of selected amino acids (histidine, tryptophan, tyrosine) from model suspensions prepared by co-precipitation with zinc chloride. It has been proven that the influence of the Zn(II)/amino acid molar ratio on dissolution profiles of the tested amino acids and dissolution half-life (t
1/2) of histidine or tryptophan is significant. The amount of amino acid in the dispersed phase (supporting dose) is a determinant of the amino acid release profile. There is a minimal supporting dose (30.0 μmol of histidine or 17.4 μmol of tryptophan) that provides release of similar amounts of amino acid (4.1–4.6 μmol of histidine or 8.7–9.9 μmol of tryptophan) after the same time intervals. The tyrosine release profiles follow first order kinetics since the supporting dose (0.9–11.2 μmol) is limited by the tyrosine low solubility in water.
Piecewise function parameters as responses of the design of experiment in the development of a pulsatile release chronopharmaceutical system
Authors: Vonica-Gligor Andreea Loredana , Tomuţă Ioan , Leucuţa Sorin E. 
Published: June 2016

Abstract
The aim of this work was to develop a pulsatile release system with metoprolol for chronotherapeutical use by coating swellable mini-tablets with Eudragit RS. To study the influence of the formulation factors (amount of coating polymer, plasticizer percentage in film coating and swelling agent percentage in mini-tablets), a Box-Behnken design of experiment (DoE) was used. To evaluate the influence of the studied factors on the sigmoid shape of the dissolution profile, piecewise function parameters were used as the responses of DoE. The results show that higher concentrations of coating polymer and higher concentrations of plasticizer polymer led to a thicker and more elastic polymeric film, which led to a delay in drug release. Using the parameters of the piecewise function as DoE responses, an optimum formulation with a sigmoid shape dissolution profile and a 2.5-h lag time followed by rapid drug release were obtained.
Strong Unique Ergodicity of Random Dynamical Systems on Polish Spaces
Authors: Płonka Paweł 
Published: June 2016

Abstract
In this paper we want to show the existence of a form of asymptotic stability of random dynamical systems in the sense of L. Arnold using arguments analogous to those presented by T. Szarek in [6], that is showing it using conditions generalizing the notion of tightness of measures. In order to do that we use tightness theory for random measures as developed by H. Crauel in [2].
Parentification and Grandparents’ Support from the Perspective of Grandchildren from Families of Various Structures
Authors: Napora Elżbieta 
Published: June 2016

Abstract
The purpose of this study was to determine the strength of the relationship between a retrospective evaluation of the experienced social support given by grandparents and the material status of the family with the quality of life of the grown-up grandchildren in families of different structures. The formulated expectations have been verified with the Social Support Scale (SSS), Student’s Life Satisfaction Scale (SLSS) and an individual personal survey. The obtained results show that in families of single mothers, the emotional and informative support offered by grandparents was a significant factor improving the quality of the life of the grandchildren. In a complete family, however, the significant forms of support from grandparents were esteem support and its other forms, except for informative support. Moreover, the material wealth of the original family was shown to be an important predictor of the evaluation of the quality of life of the grandchildren; it was judged more negatively by adolescent children of single mothers.
The Potential of Biotechnology Investments in Selected Eastern European Countries: Lost Chances
Authors: Vida Patrik 
Published: June 2016

Abstract

Background: Biotechnology is rapidly developing on a global scale. However, some evidence indicates that Eastern European (EE) countries are not fulfilling their potential in this field.

Objectives: This paper aims to examine whether selected EE countries are able to develop a strong biotechnology industry. Potential investment approaches and the existing but not used or neglected infrastructures in EE countries were also examined.

Methods/approach: In order to determine biotechnological activities in EE countries, indicators such as intellectual property protection, venture capital availability, published scientific publications as well as other indicators were analyzed. These indicators were compiled and compared between EE countries and regions with a rich and diverse biotechnological business sector.

Results: The results suggest an underdeveloped biotechnology business sector in EE countries, with talented but unexploited scientists and unutilized infrastructure. The systematic drawbacks of EE countries lead to a hostile investment environment.

Conclusions: The findings make a significant contribution to understanding how the biotechnology industry in EE countries is structured and how investments can be rationally placed. EE countries need to adapt their venture capital market for biotechnology ventures. Several changes in regulations could have a large impact on biotechnology investments.
The Use of Kramers-Kronig Relations for Verification of Quality of Ferrite Magnetic Spectra
Authors: Ponomarenko Nikolajs , Solovjova Tatjana , Grizans Juris 
Published: June 2016

Abstract
The complex initial permeability (CIP) as a function of frequency is one of the main properties of ferrites. This characteristic (CIP) is measured experimentally, therefore there can be found noisy, doubtful or incomplete parts of the spectrum. Thus there is a need for a method of evaluation of quality of CIP. In this article for evaluation of the quality of experimental CIP spectra of polycrystalline ferrite materials the KKR (Kramers-Kronig relations) are used. In order to apply KKR to experimentally measured data (i.e. data with finite limits) the method of transforming these integral relations into summation relations with finite limits is developed and described. This method can be used only for CIP given over the wide frequency rage, so that the imaginary part of CIP is fully presented. Using KKR with the help of CIP spectra model (based on the effects coming from polycrystal grain sizes and defects distribution) partly removes aforementioned limit. Thus with the help of the model we can also make CIP spectra reconstruction (in cases when CIP is noisy or incomplete) and CIP spectra decomposition.
Small terrestrial mammals living along streams acting as natural landscape barriers
Authors: Bohdal Tomáš , Navrátil Josef , Sedláček František 
Published: June 2016

Abstract
Riparian stands along streams are important landscape elements – biocorridors, allowing the dispersal of many small terrestrial mammals. Streams are, however, also barriers limiting dispersal, which leads to isolation and population-genetic changes. Communities of small terrestrial mammals (Eulipotyphla, Rodentia) were studied in 2004 to 2006 on five watercourses of varying widths in Central European cultural landscape situated in South Bohemia (Czech Republic). In total, 547 individuals from 10 species were captured by the Capture-Mark-Recapture method (CMR). Yellow-necked mouse (Apodemus flavicollis) and bank voles (Myodes glareolus) were eu-dominant species at all locations. Species diversity and equitability rose with the degree of the barrier – proportional to the width of the stream.
The terrestrial mobility of selected species was also assessed. Apodemus flavicollis indicated overall highest values of mobility, and Myodes glareolus males also scored higher values, however, the width of the stream did not correlate with mobility in these species. The animals crossed water-courses on the order of tens of meters wide in the period of 3 months. The frequency of crossing of Apodemus flavicollis decreased exponentially with the width of the stream and was dependent on population density.
How Do Entrepreneurs Develop Business Models in Small High-Tech Ventures? An Exploratory Model from Australian IT Firms
Authors: Najmaei Arash 
Published: June 2016

AbstractThe objective of this article is to explore and explain how entrepreneurs develop new business models for new ventures. Though highly topical, there is little solid empirical knowledge of this issue. Findings from multiple case studies of firms operating in the Australian cloud-computing ecosystem reveal that developing a new business model involves three phases. In the first phase (business modelling ideation (BMI)), various ideas for a viable business model are generated and the most viable one is chosen. The strategic consensus and commitment are generated in the second phase, labelled as the “business modelling strategic commitment” (BMSC). The third phase, labelled as the “business model actualization” (BMAC) is the market-testing phase where the business model is reified or actualized. The theoretical and managerial implications of the findings are discussed and several directions for future research are suggested.
Investigation of 16 × 10 Gbps DWDM System Based on Optimized Semiconductor Optical Amplifier
Authors: Rani Aruna , Dewra Sanjeev 
Published: June 2016

AbstractThis paper investigates the performance of an optical system based on optimized semiconductor optical amplifier (SOA) at 160 Gbps with 0.8 nm channel spacing. Transmission distances up to 280 km at –30 dBm input signal power and up to 247 km at –32 dBm input signal power with acceptable bit error rate (BER) and
Development and application of a TaqMan-MGB real-time RT-PCR assay for the detection of porcine epidemic diarrhoea virus strains in China
Authors: Hou Yi-Xuan , Xie Chun , Wang Kang , Zhao Yu-Ting , Xie Yang-Yang , Shi Hong-Yan , Chen Jian-Fei , Feng Li , Tong Guang-Zhi , Hua Xiu-Guo , Yuan Cong-Li , Zhou Yan-Jun , Yang Zhi-Biao 
Published: June 2016

Abstract

Introduction: A real-time RT-PCR method for identification and quantification of porcine epidemic diarrhoea virus (PEDV) strains in China was developed.

Material and Methods: Based on the conserved sequence of the PEDV nucleocapsid (N) gene, a primer pair and probe were designed to establish a TaqMan-MGB real-time RT-PCR assay for quantitative detection of the virus. The sequence was cloned into the pMD18-T vector and a series of diluted recombinant plasmids were used to generate a standard curve with an R2 value of 0.999.

Results: The developed quantitative PCR assay detected viral titres as low as 0.1 TCID50 with high specificity and no cross-reaction with other porcine viruses (PoRV, TGEV, PRRSV, or CSFV). The intra-batch and inter-batch coefficients of variation were both less than 1%, which indicated good reproducibility. Thirty clinical diarrhoea samples obtained from pigs in Shanghai and Fujian were analysed using this quantitative PCR assay. Out of these samples, 93.3% were found to be PEDV positive.

Conclusion: This approach is suitable for clinical sample identification and pathogenesis studies.
Red foxes (Vulpes vulpes) as reservoirs of respiratory capillariosis in Serbia
Authors: Ilić Tamara , Becskei Zsolt , Tasić Aleksandar , Stepanović Predrag , Radisavljević Katarina , Đurić Boban , Dimitrijević Sanda 
Published: June 2016

Abstract

Introduction: The aim of the study was to determine the prevalence of respiratory capillariosis in red foxes (Vulpes vulpes) in some regions of Serbia.

Material and Methods: The study was conducted on 102 foxes in six epizootiological regions of Serbia, during the hunting season between 2008 and 2012.

Results: The presence of respiratory capillariosis in all tested epizootiological regions was confirmed. The E. aerophilus nematode was detected with overall prevalence of 49.02%. The diagnosis of E. aerophilus infection was confirmed by the determination of morphological characteristics of adult parasites found at necropsy and the trichurid egg types collected from the bronchial lavage and the content of the intestine.

Conclusion: The presented results contribute to better understanding of the epidemiology of this nematodosis in Serbia. However, the high prevalence of capillaries in tested foxes, demonstrated in all explored areas, might suggest that foxes from other regions in Serbia may also be infected. The fact that domestic carnivores and humans can also be infected enhances the importance of the overall epidemiological status. To establish the relevant prevalence of respiratory capillariosis, further investigations and continous monitoring of parasitic fauna of carnivores are needed in the whole country.
Electroencephalography as a diagnostic technique for canine neurological diseases
Authors: Wrzosek Marcin 
Published: June 2016

Abstract
Electroencephalography (EEG) is a non-invasive examination method for the assessment of functional central nervous system (CNS) disturbances. In human medicine it has a special importance as a diagnostic tool for epilepsy. Although many studies were done on the use of EEG for diagnostics of canine central nervous system disorders, the technique is still not applied routinely. The purpose of this paper was to review the use of the electroencephalography in canine neurological disorders of central nervous system diagnosis and assess the future perspectives of this technique in veterinary medicine.
Enrofloxacin decreases IL-6 and TNF-α production by lipopolysaccharide-stimulated porcine peripheral blood mononuclear cells
Authors: Pomorska-Mól Małgorzata , Czyżewska-Dors Ewelina , Kwit Krzysztof , Pejsak Zygmunt 
Published: June 2016

Abstract

Introduction: The aim of the study was to explore the effect of enrofloxacin on production of selected cytokines by porcine peripheral blood mononuclear cells (PBMCs).

Material and Methods: Twenty pigs (10 control and 10 experimental) were used in this research. Pigs from experimental group received enrofloxacin at therapeutic doses. Blood samples were collected before, during, and after treatment with enrofloxacin. PBMCs were incubated with or without lipopolysaccharide (LPS). Production of IL-6, IL-10, INF-γ, and TNF-α were determined by ELISA.

Results: Administration of enrofloxacin to healthy pigs for 5 d induced a transient reduction of the PBMCs response to LPS in terms of IL-6 and TNF-α secretion. The concentration of IL-6 returned to the day 0 level shortly after treatment, while TNF-α production remained reduced for 10 d after the treatment. The production of IL-10 was not affected by enrofloxacin. The level of IFN-γ was below the detection limit of the tests.

Conclusion: The results indicate that enrofloxacin administered in vivo in therapeutic doses has an immunomodulatory effect through its capacity to inhibit secretion of IL-6 and TNF-α by porcine PBMC stimulated by LPS.
Modulators of KATP channels in the prevention of oxidative stress and antioxidant capacity improvement in the rat heart with different resistance to hypoxia upon cobalt treatment
Authors: Kurhaluk Natalia , Tkachenko Halyna 
Published: June 2016

Abstract

Introduction: The main goal of the study was to investigate the effect of KATP channel modulators on development of oxidative stress in the heart of rats showing different resistance to hypoxia.

Material and Methods: The study has been performed on rats showing high- (HR) or low-resistance (LR) to hypoxia under modulators of ATP-sensitive potassium (KATP) channel opener pinacidil (0.06 mg/kg) and blocker glibenclamide (1 mg/kg) upon cobalt (Co) treatment (30 mg of cobalt chloride/kg b.w., 3 h). Changes in the oxidative stress parameters of the heart tissue, such as lipid peroxidation (LPO), level of oxidatively modified protein (OMP), and antioxidant defence system (superoxide dismutase - SOD, catalase -CAT, glutathione peroxidase - GPx, glutathione reductase - GR) as well as total antioxidant activity (TAA) were analysed.

Results: Co treatment caused a significant decrease in SOD and CAT activity in the heart of LR rats and GPx activity in HR rats. It also led to a decrease in OMP level in the heart of rats with HR in comparison with controls.

Conclusion: The obtained results suggest that individual resistance to hypoxia plays a crucial role in Co actions and provides evidence that the effects of KATP channel opener pinacidil in the heart are mediated through different pathways of the antioxidative system, depending on the individual resistance to hypoxia. Pinacidil exerts a protective effect on the heart tissue by preventing the LPO decrease and significantly reducing OMP levels, as well as increasing TTA in rats with LR.
Statistical Analysis of Detailed 3-D CFD LES Simulations with Regard to CCV Modeling
Authors: Vítek Oldřich , Macek Jan , Pavlovic Zoran , Tatschl Reinhard 
Published: June 2016

Abstract
The paper deals with statistical analysis of large amount of detailed 3-D CFD data in terms of cycle-to-cycle variations (CCVs). These data were obtained by means of LES calculations of many consecutive cycles. Due to non-linear nature of Navier-Stokes equation set, there is a relatively significant CCV. Hence, every cycle is slightly different – this leads to requirement to perform statistical analysis based on ensemble averaging procedure which enables better understanding of CCV in ICE including its quantification. The data obtained from the averaging procedure provides results on different space resolution levels. The procedure is applied locally, i.e., in every cell of the mesh. Hence there is detailed CCV information on local level – such information can be compared with RANS simulations. Next, volume/mass averaging provides information at specific locations – e.g., gap between electrodes of a spark plug. Finally, volume/mass averaging of the whole combustion chamber leads to global information which can be compared with experimental data or results of system simulation tools (which are based on 0-D/1-D approach).