bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital Health Technology Use Across Socioeconomic Groups Prior to and During the COVID-19 Pandemic: Panel Study
Authors: Tuitert Inge , Marinus Jesse D , Dalenberg Jelle R , van 't Veer Job TB 
Published: September 2024

Background
Digital technologies have become more important in the health care sector in the past decades. This transition from conventional to digital health care has been accelerated by the impact of the COVID-19 pandemic, which poses the risk of creating a “digital divide,” inadvertently placing those who are older, economically disadvantaged, and have a lower level of education at a disadvantage.

Objective
This study focuses on the influence of socioeconomic factors on the adoption of digital health technology in the Frisian population and how this relation is affected by the COVID-19 pandemic.

Methods
In 2019 and 2020, a panel study was conducted on digital health in the Frisian population in the Netherlands. In the survey, the use of digital health technology was operationalized in a broad sense, going beyond the care context by also including preventative health-promoting solutions generally available on the consumer market, such as wearables and lifestyle apps. First, to assess the influence of socioeconomic factors on the total use of digital health apps, a generalized linear model was fitted with use of digital health app as the dependent variable and socioeconomic factors as between-subject factors on the 2019 data. Second, to analyze whether the use of separate health apps increased from 2019 to 2020, we conducted chi-square tests on different digital health app types. Third, to examine the influence of COVID-19 on the use of digital health apps, a generalized linear mixed model was fitted with the use of digital health apps as the dependent variable, COVID-19 as the within-subject variable, and socioeconomic factors as between-subject factors.

Results
The results indicated that prior to the COVID-19 pandemic, digital health technology use was higher in women, younger people, and those who are well educated and economically more privileged. Moreover, the percentage of people who reported using digital health technology rose from 70% (1580/2258) to 82.5% (1812/2197) due to the COVID-19 pandemic. This increase was significant for all separate types of digital health technology (all P<.001). In addition, we found the interaction effects of COVID-19 with age and education attainment, indicating that the lower total use among older people and people with lower education attainment became slightly less apparent from 2019 to 2020.

Conclusions
These findings on the influence of the COVID-19 pandemic on the digital divide indicated that the use of all types of digital health apps increased and that older individuals and people with a lower level of education caught up a little during COVID-19. Future research should gain more insight into this effect and examine whether it persists beyond the COVID-19 pandemic. Additionally, future endeavors should focus on vulnerable groups, ensuring they receive adequate attention to guarantee access to health care, preventative health-promoting solutions, and social services.
Uptake of Digital Health Interventions for Cardiometabolic Disease in British South Asian Individuals: Think Aloud Study
Authors: Ramasawmy Mel , Roland Persson Dan , Sunkersing David , Gill Paramjit , Khunti Kamlesh , Poole Lydia , Hanif Wasim , Blandford Ann , Sajid Madiha , Stevenson Fiona , Khan Nushrat , Banerjee Amitava 
Published: September 2024

Abstract

Background
Digital health interventions (DHIs) could support prevention and management of cardiometabolic disease. However, those who may benefit most often experience barriers to awareness and adoption of these interventions.

Objective
Among South Asian individuals, we evaluated user experience of DHIs for prevention and management of cardiometabolic disease, aiming to understand barriers and facilitators to initial and ongoing use.

Methods
Among South Asian individuals recruited via primary care, community organizations, and snowball methods (n=18), we conducted “think-aloud” interviews using a reflective and reactive approach. Participants included nonusers, as well as those that used a range of DHIs as part of monitoring and improving their health. Participants were asked to think aloud while completing a task they routinely do in a familiar DHI, as well as while setting up and completing a search task in a novel DHI; they were encouraged to behave as if unobserved.

Results
Lack of cultural specificity was highlighted as reducing relevance and usability, particularly relating to dietary change. Preferred features reflected individual health beliefs and behaviors, digital skills, and trust in DHIs. For example, tracking blood glucose was considered by some to be positive, while for others it caused distress and anxiety. Similarly, some users found the novel DHI to be extremely simple to set up and use, and others grew frustrated navigating through initial interfaces. Many participants raised concerns about data privacy and needing to agree to terms and conditions that they did not understand. Participants expressed that with information and support from trusted sources, they would be interested in using DHIs as part of self-management.

Conclusions
DHIs may support South Asians to prevent and manage cardiometabolic disease, but it is important to consider the needs of specific user groups in DHI development, design, and implementation. Despite motivation to make health changes, digital barriers are common. Cultural appropriateness and trusted sources (such as health care providers and community organizations) have roles in increasing awareness and enabling individuals to access and use DHIs.
Factors Impacting the Adoption and Potential Reimbursement of a Virtual Reality Tool for Pain Management in Switzerland: Qualitative Case Study
Authors: Lurtz Josefine , C Sauter Thomas , Jacob Christine 
Published: September 2024

Abstract

Background
Pain and its adequate treatment are an issue in hospitals and emergency departments (EDs). A virtual reality (VR) tool to manage pain could act as a valuable complement to common pharmaceutical analgesics. While efficacy could be shown in previous studies, this does not assure clinical adoption in EDs.

Objective
The main aim of this study was to investigate which factors affect the adoption and potential reimbursement of a VR tool for pain management in the ED of a Swiss university hospital.

Methods
Key informant interviews were conducted using in-depth semistructured interviews with 11 participants reflecting the perspectives of all the relevant stakeholder groups, including physicians, nurses, patients, health technology providers, and health insurance and reimbursement experts. The interviews were recorded and transcribed, and the extracted data were systematically analyzed using a thematic analysis and narrative synthesis of emergent themes. A consolidated framework for eHealth adoption was used to enable a systematic investigation of the topic and help determine which adoption factors are considered as facilitators or barriers or as not particularly relevant for the tool subject of this study.

Results
According to the participants, the three key facilitators are (1) organizational environment; (2) tension for change, ease of use, and demonstrability; and (3) employee engagement. Further, the three key barriers to adoption are (1) workload, (2) changes in clinical workflow and habit, and (3) reimbursement.

Conclusions
This study concludes that the adoption of a VR tool for pain management in the ED of the hospital subject of this study, although benefiting from a high tension for change in pain and workload management, is highly dependent on the respective organizational environment, engagement of the clinical staff, and reimbursement considerations. While tailored incentive structures and ambassador roles could benefit initial adoption, a change in the reimbursement landscape and further investigation of the positive effects on workflow effectiveness are required to drive long-term adoption.
Association of a Novel Electronic Form for Preoperative Cardiac Risk Assessment With Reduction in Cardiac Consultations and Testing: Retrospective Cohort Study
Authors: Kumar Mandeep , Wilkinson Kathryn , Li Ya-Huei , Masih Rohit , Gandhi Mehak , Saadat Haleh , Culmone Julie 
Published: September 2024

Background
Preoperative cardiac risk assessment is an integral part of preoperative evaluation; however, there is significant variation among providers, leading to inappropriate referrals for cardiology consultation or excessive low-value cardiac testing. We implemented a novel electronic medical record (EMR) form in our preoperative clinics to decrease variation.

Objective
This study aimed to investigate the impact of the EMR form on the preoperative utilization of cardiology consultation and cardiac diagnostic testing (echocardiograms, stress tests, and cardiac catheterization) and evaluate postoperative outcomes.

Methods
A retrospective cohort study was conducted. Patients who underwent outpatient preoperative evaluation prior to an elective surgery over 2 years were divided into 2 cohorts: from July 1, 2021, to June 30, 2022 (pre–EMR form implementation), and from July 1, 2022, to June 30, 2023 (post–EMR form implementation). Demographics, comorbidities, resource utilization, and surgical characteristics were analyzed. Propensity score matching was used to adjust for differences between the 2 cohorts. The primary outcomes were the utilization of preoperative cardiology consultation, cardiac testing, and 30-day postoperative major adverse cardiac events (MACE).

Results
A total of 25,484 patients met the inclusion criteria. Propensity score matching yielded 11,645 well-matched pairs. The post–EMR form, matched cohort had lower cardiology consultation (pre–EMR form: n=2698, 23.2% vs post–EMR form: n=2088, 17.9%; P<.001) and echocardiogram (pre–EMR form: n=808, 6.9% vs post–EMR form: n=591, 5.1%; P<.001) utilization. There were no significant differences in the 30-day postoperative outcomes, including MACE (all P>.05). While patients with “possible indications” for cardiology consultation had higher MACE rates, the consultations did not reduce MACE risk. Most algorithm end points, except for active cardiac conditions, had MACE rates <1%.

Conclusions
In this cohort study, preoperative cardiac risk assessment using a novel EMR form was associated with a significant decrease in cardiology consultation and testing utilization, with no adverse impact on postoperative outcomes. Adopting this approach may assist perioperative medicine clinicians and anesthesiologists in efficiently decreasing unnecessary preoperative resource utilization without compromising patient safety or quality of care.
Estimation of Metformin Hydrochloride in Bulk and Formulation by UV - Spectroscopic Area Under Curve Method
Authors: Kakade Vrushali B , Lobhe G.A. , Gandhat Snehal G. , Dhobale S. M., , Patel Salim G. 
Published: September 2024

The current work is carried out for estimation of Metformin Hydrochloride by using area under curve (AUC) method using UV-visible spectrophotometer. For this purpose the wavelength range 221-241 nm was selected. Distilled water was used as a solvent throughout the work. Linearity was observed in concentration range 5-25 µg/ml (R2= 0.994) for the method. The present method was found to be simple and linear which can be used for routine quality control analysis for spectrophotometric estimation of Metformin hydrochloride in bulk.
Keywords: Metformin Hydrochloride, Area under curve, Antidiabetic, λmax.
Constrictive pericarditis following Dressler’s syndrome induced by percutaneous coronary arteriography
Authors: Al-Bader Dalal , El-Reshaid Kamel 
Published: September 2024

Constrictive pericarditis (CP) is a chronic inflammatory process characterized by chronic scarring, fibrosis and calcification of the pericardium associated with diastolic dysfunction, eventually leading to low cardiac output and heart failure. Idiopathic pericarditis remains the predominant cause of CP in the western world, followed by surgery and radiation therapy. Tuberculous pericarditis is still the leading cause of CP in developing countries and immunocompromised patients. Dressler’s syndrome is an autoimmune pericarditis which has been rarely reported following myocardial infarction and cardiotomy cases and lately after percutaneous coronary intervention (PCI). However, CP following PCI is exceedingly rare. Herein, we report a case of CP following an uncomplicated coronary angioplasty and stenting.
Keywords: constrictive pericarditis, Dressler’s syndrome, percutaneous coronary intervention, pericardiectomy.
A simple randomized comparative study to evaluate the efficacy of 0.7% w/v Olopatadine hydrochloride ophthalmic solution and the Fixed Dose Combination of 0.1% w/v Olopatadine hydrochloride and 0.4% w/v Ketorolac tromethamine ophthalmic solution for the
Authors: Jagarlamudi Anup , Anushree E. , Harika Soma , Kavya Sri K. , Rohit Ch. 
Published: September 2024

Conjunctivitis is defined as the inflammation of the conjunctiva. Allergic conjunctivitis is an acute, intermittent or chronic inflammation of the conjunctiva due to air borne allergens. Allergic reactions occur when the immune system is hypersensitive to normally harmless environmental substances, called allergens. Allergic conjunctivitis is an increasingly prevalent allergic reaction and currently 40% of global population is suffering from allergic conjunctivitis. Being an immunopathological disease, Conjunctival mast cell degranulation plays a major role in ocular allergic disease and so treatment options should be concentrated on preventing degranulation or of antagonizing the effects of the primary mediator, histamine. Commonly used medications are: Topical OTC antihistamines (eg, ketotifen) , topical prescription antihistamines (eg, olopatadine, bepotastine, alcaftadine), NSAIDs (eg, ketorolac), or mast cell stabilizers (eg, nedocromil, cromolyn, azelastine) and can be used separately or in combination. In our study, the safety profile of Olopatadine 0.7% is comparable with fixed dose combination of Olopatadine 0.1% and ketorolac tromethamine 0.4% by assessing the reduction in the severity of four parameters (ocular itching, conjunctival hyperemia, chemosis and tearing) of allergic conjunctivitis over 14 days of daily treatment. Ours is a Prospective case observational study conducted from August 2018-January 2019. A total of 80 patients were screened from the ophthalmology outpatient department. All the subjects who fulfilled eligibility criteria were randomly assigned in equal proportions into two arms i.e, group-1(patients receiving 0.7% olopatidine Hcl eye drops) & group-2( patients receiving 0.1% olopatidine Hcl+ 0.4% ketorolac tromethamine eye drops.). It was observed that there was a significant difference in the percentage reduction of all the four parameters in the group 1 (i.e; patients treated with monotherapy) than the group 2 (i.e; patients treated with combination therapy). From this we concluded that monotherapy of 0.7% Olopatadine hydrochloride ophthalmic solution was found to be more effective in reducing the clinical signs and symptoms of allergic conjunctivitis than dual combination therapy of 0.1% Olopatadine hydrochloride + 0.4% Ketorolac tromethamine ophthalmic solution.
Effect of bio-adsorbents (Strychnos potatorum seed) for elimination of methyl orange dye from polluted waters
Authors: Gangwar Usma , Choubey Anita 
Published: September 2024

The use of cheap, high efficiency and ecofriendly adsorbent has been studied as an alternative source of activated carbon for the removal of dye from wastewater. Bio-adsorbents derived from plant materials of Strychnos Potatorum Seed have been probed for their surface sorption abilities towards Methyl Orange Dye using simulated waters. The parameters studied were the effect of pH, amount of adsorbent, contact time and concentration of adsorbate. Equilibrium data were fitted to the Langmuir and Freundlich isotherm models. The data were best represented by the Langmuir model with an adsorption capacity and adsorption intensity. The adsorption was found to be concentration dependent and the maximum adsorption was occurred in 3 hrs. Thus, from the results of adsorption data, it was concluded that the Strychnos potatorum seed powder was found to be excellent adsorbent for the adsorption of methyl orange dye from industrial waste water.
Keywords: Strychnos Potatorum, Methylene orange, Removal, Adsorption, Isotherm
THE Solid lipid nanoparticles A review
Authors: Patil Prashant , Harak Komal , Saudagar Ravindra 
Published: September 2024

Solid lipid nanoparticles are novel drug delivery system its to improve the solubility and bioavailability of the drug it has been proved that SLN is more effective colloidal drug delivery system because of it is more controlled and targeting properties, the SLN as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs, the bioacceptable and biodegradable nature of SLN makes them less toxic as compared to polymeric nanoparticles, it has several potential applications in drug delivery, clinical medicine and research as well as in other varied science, in this present review this new approach is discussed in terms of their method of preparations, applications, advantages, characterization and other special features ,the SLN may open new therapy to treat difficult diseases like complex.
Keywords: solid lipid nanoparticles, drug released, method of preparations.
A Review on Nanohybrids: Technique for Solubility Enhancement of Poorly Water Soluble Drugs
Authors: Nigal Aparna , Darekar Avinash , Saudagar Ravindranath 
Published: September 2024

In order the drug bioavailable in human body must absorb it, and in oral treatments absorption takes place, after drug dissolution by diffusion of the molecules through gastrointestinal membranes. It was found that BCS class –II drug has poor aqueous solubility in GI tract greatly influences the drug release; particularly it affects the bioavailability of drug. Solubilization of water insoluble drug is a big issue of pharmaceutical research. Nanohybrids are combination of two or more different materials with different properties of each and that are fused, by an effort to blend the best properties of both. In nanohybrids there is use of natural and synthetic polymers. The present review mainly focusing on the simple and convenient method of preparation of nanohybrids with the help of Microwave irradiation Method by using natural/synthetic carriers such as acacia, gelatin, cassia, ghatti gum, and HPMC, MC etc. to enhance the solubility of poorly water soluble BCS Class –II Drugs and improved its rate of dissolution for such drug entities which affects the bioavailability. Prepared nanohybrids can be characterized by Scanning Electron Microscopy, Fourier transform infrared spectroscopy, Differential Scanning Calorimetry, X-Ray Diffraction Studies and transmission Electron Microscopy. Further, this review mainly highlights the application and future prospective use of nanohybrids, which will help in formulation of drug with improved bioavailability.
Keywords: BCS Class II, Nanohybrids, Solubilization, Enhancement of solubility, Optimized drug dissolution and drug release.
Protective role of Carica papaya and Ficus bengalensis latex against CCl4 induced liver toxicity in experimental rats
Authors: Kumar Yogendra , Gautam Girendra , Mishra Pushpesh Kumar 
Published: September 2024

Objective: To study the hepatoprotective activity of Carica Papaya Latex at the dose 400mg/kg/b.w. per oral and Ficus Bengalensis latex at dose 300mg/kg/b.w. per oral against CCl4 induce Hepatotoxicity in albino rats.
Method: Animals were divided into 5 groups of 6 animals in each group.
Group I – Served as a normal control received saline 1ml /Kg for 21 days. The group -II, III, IV and V animals were received CCl4 at dose 1ml/Kg b.w./day intra- peritoneally. Animals from group –III to V received Carica Papaya Latex (400mg/Kg.p.o.), Ficus Bengalensis Latex (300mg/Kg.p.o.) and standard drug Silymarin (30mg/Kg.p.o.) once daily for 21 days. All groups animals were sacrificed on 22 days under light ether anesthesia . Blood sample were collected and used for bio-chemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), Bilirubin(BRN), Alkaline phosphate (ALP) and total protein.
Result:The results were observed that Carica Papaya latex at dose 400 mg/kg.b.w and CCl4 treated group , Ficus Bengalensis latex at dose 300 mg/kg.B.w and CCl4 treated groups were found the decreased levels of SGPT,SGOT,, ALP and Bilirubin and increased total protein level compare to CCl4 treated group .So that this study indicated hepatoprotective effect .
Conclusion: Present investigation indicated that both latex of Carica papaya and Ficus Bengalensis showed significant protection against CCl4 nduced hepatotoxicity in Rats.
Keywords: Carica Papaya, Ficus Bengalensis, Hepatoprotective, Carbon Tetra Chloride, Silymarin.
Glycemic and Psychosocial Outcomes of Advanced Hybrid Closed-Loop Therapy in Youth With High HbA1c: A Randomized Clinical Trial
Authors: Abraham Mary B. , Smith Grant J. , Dart Julie , Clarke Antony , Bebbington Keely , Fairchild Janice M. , Ambler Geoffrey R. , Cameron Fergus J. , Davis Elizabeth A. , Jones Timothy W. 
Published: September 2024

OBJECTIVE
To determine the efficacy of advanced hybrid closed-loop (AHCL) therapy in a high-risk cohort of youth on continuous subcutaneous insulin infusion (CSII) with or without continuous glucose monitoring (CGM) with suboptimal glycemia.

RESEARCH DESIGN AND METHODS
In a 6-month multicenter clinical trial, youth with type 1 diabetes with mean and most recent HbA1c &gt;8.5% (65 mmol/mol) were randomly assigned 1:1 to AHCL or treatment as usual (CSII ± CGM). The primary outcome was the 24-week between-group difference in HbA1c. Secondary outcomes included CGM metrics from masked CGM and psychological measures (youth-reported problem areas in diabetes [PAID], quality of life, anxiety, depression, and hypoglycemia fear) assessed using validated questionnaires.

RESULTS
A total of 42 participants were randomized (mean [SD] age 16.2 [2.5] years, HbA1c 9.8 [1.1]% or 84 [12] mmol/mol, PAID score 50.3 [19.8]). At study end, the mean (SD) HbA1c was 8.8 (1.1)% or 73 (12) mmol/mol with AHCL and 9.9 (1.2)% or 85 (13.1) mmol/mol with CSII ± CGM, with mean adjusted group difference of −0.77% (95% CI −1.45 to −0.09) or −8.4 mmol/mol (−15.8 to −1.0); P = 0.027. AHCL increased time in range 70–180 mg/dL (difference 19.1%; 95% CI 11.1 to 27.1), reduced time &gt;180 mg/dL (difference −17.7%; 95% CI −26.6 to −8.8), with no increase in time spent &lt;70 mg/dL (difference −0.8%; 95% CI −2.7 to 0.6). There was no evidence for difference in psychosocial outcomes between the two groups at study end.

CONCLUSIONS
AHCL should be encouraged in youth with suboptimal glycemia, as AHCL improves glycemia. However, psychological support remains vital, as technology alone may not be able to reduce the burden of diabetes care in this subgroup.