bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mammographic breast density is associated with the development of contralateral breast cancer
Authors: Raghavendra Akshara , Sinha Arup K. , Le‐Petross Huong T. , Garg Naveen , Hsu Limin , Patangan Modesto , Bevers Therese Bartholomew , Shen Yu , Banu Arun , Tripathy Debu , Bedrosian Isabelle , Barcenas Carlos H. 
Published: January 2017

BACKGROUNDWomen with dense mammographic breast density (BD) have a 2‐fold increased risk of developing primary breast cancer (BC). The authors hypothesized that dense mammographic BD also is associated with an increased risk of developing contralateral breast cancer (CBC).METHODSAmong female patients treated at The University of Texas MD Anderson Cancer Center for sporadic, AJCC stage I to stage III BC between January 1997 and December 2012, the authors identified patients who had developed metachronous CBC (cases) and selected 1:2 matched controls who did not develop CBC using incidence density sampling, matched on attainted age, year of diagnosis, and hormone receptor status of the first BC. Mammographic BD, assessed at the time of first BC diagnosis, was categorized as “nondense” (American College of Radiology breast categories of fatty or scattered density) or “dense” (American College of Radiology categories of heterogeneously dense or extremely dense). Multivariable conditional logistic regression models were used for statistical analysis.RESULTSA total of 229 cases and 451 controls were evaluated. Among the cases, approximately 39.3% had nondense breast tissue and 60.7% had dense breast tissue. Among controls, approximately 48.3% had nondense breast tissue and 51.7% had dense breast tissue. After adjustment for potential prognostic risk factors for BC, the odds of developing CBC were found to be significantly higher for patients with dense breasts (odds ratio, 1.80; 95% confidence interval, 1.22‐2.64 [P<.01]) than for those with nondense breasts. Patients who received chemotherapy or endocrine therapy were less likely to develop CBC.CONCLUSIONSIn women with primary BC, mammographic BD appears to be a risk factor for the development of CBC. Cancer 2017;123:1935–1940. © 2017 American Cancer Society.
Study of the Effect of Water Pressure on Plasma and Cavitation Bubble Induced by Pulsed Laser Ablation in Liquid of Silver and Missed Variations of Observable Nanoparticle Features
Authors: Dell'Aglio Marcella , Santagata Antonio , Valenza Gabriele , De Stradis Angelo , De Giacomo Alessandro 
Published: January 2017

AbstractIn this work the effects of the pressure between 1–150 Bar on pulsed laser ablation in liquids (PLAL) during the production of silver nanoparticles (AgNPs) in water was investigated. The produced NPs are the results of two different well‐known stages which are the plasma and the bubble evolution occurring until the generated material is released into the solution. The main aim of this work is to show which roles is played by the variation of water pressure on the laser induced plasma and the cavitation bubble dynamics during the NPs formation. Their implication on the comprehension of the as‐produced NPs formation mechanisms is treated. The typical timescales of the different stages occurring in water at different pressures have been studied by optical emission spectroscopy (OES), imaging and shadowgraph experiments. Finally surface plasmon resonance (SPR) spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS) and scanning electron microscopy (SEM) for characterization of the material released in solution, have been used.
Minimum spanning tree–based delay‐aware mobile sink traversal in wireless sensor networks
Authors: Nitesh Kumar , Azharuddin Md , Jana Prasanta 
Published: January 2017

SummaryEnergy efficient data collection in a delay‐bound application is a challenging issue for mobile sink–based wireless sensor networks. Many researchers have proposed the concept of rendezvous points (RPs) to design the path for the mobile sink. Rendezvous points are the locations in the network where the mobile sink halts and collects data from the nearby sensor nodes. However, the selection of RPs for the design of path has a significant impact on timely data collection from the network. In this paper, we propose an efficient algorithm for selection of the RPs for efficient design of mobile sink trajectory in delay‐bound applications of wireless sensor networks. The algorithm is based on a virtual path and minimum spanning tree and shown to maximize network lifetime. We perform extensive simulations on the proposed algorithm and compare results with the existing algorithms to demonstrate the efficiency of the proposed algorithm of various performance metrics.
Pairwise beta diversity resolves an underappreciated source of confusion in calculating species turnover
Authors: Marion Zachary H. , Fordyce James A. , Fitzpatrick Benjamin M. 
Published: January 2017

AbstractBeta diversity is an important metric in ecology quantifying differentiation or disparity in composition among communities, ecosystems, or phenotypes. To compare systems with different sizes (N, number of units within a system), beta diversity is often converted to related indices such as turnover or local/regional differentiation. Here we use simulations to demonstrate that these naive measures of dissimilarity depend on sample size and design. We show that when N is the number of sampled units (e.g., quadrats) rather than the “true” number of communities in the system (if such exists), these differentiation measures are biased estimators. We propose using average pairwise dissimilarity as an intuitive solution. That is, instead of attempting to estimate an N‐community measure, we advocate estimating the expected dissimilarity between any random pair of communities (or sampling units)—especially when the “true” N is unknown or undefined. Fortunately, measures of pairwise dissimilarity or overlap have been used in ecology for decades, and their properties are well known. Using the same simulations, we show that average pairwise metrics give consistent and unbiased estimates regardless of the number of survey units sampled. We advocate pairwise dissimilarity as a general standardization to ensure commensurability of different study systems.
The nonlinear effect of alkyl chain length in the membrane interactions of phenolipids: Evidence by X‐ray diffraction analysis
Authors: Durand Erwann , Jacob Robert F. , Sherratt Samuel , Lecomte Jérôme , Baréa Bruno , Villeneuve Pierre , Mason R. Preston 
Published: January 2017

Despite the evidence supporting a relationship between phenolipid's alkyl chain length and their interaction/affinity with membranes, such a connection has not been directly evaluated. In this study, the membrane interactions of rosmarinic acid, and its corresponding alkyl esters having 4 carbon (RC4), 8 carbon (RC8), 10 carbon (RC10), and 16 carbon (RC16) have been investigated via small angle X‐ray scattering (SAXS) approaches in model membrane liposomes. The results of this work show significant differences between the tested phenolipids with respect to their interaction and location within the lipid bilayer. Both membrane affinity and penetration depth follow a nonlinear behavior. They have been shown to increase as a function of increasing alkyl chain length until a threshold is reached for medium alkyl chain, beyond which any lengthening of the chain results in a collapse. RC8 show the highest affinity for the membrane, whereas RC10 constitute a critical chain length from which the penetration depth decreases. The X‐ray scattering analyses seem to perfectly correlate with the phenolipids’ activities (antioxidant and membranes crossing) previously observed both in biological system and in formulated lipid dispersions.Practical applications: Phenolic compounds are potent antioxidants that may play an important role as well in biological system as in formulated lipid dispersions. However, their activity is often limited by low solubility or bioavailability. Lipophilization of phenolic compounds may increase their solubility in lipophilic matrices, conferring better antioxidant protection for food or nonfood application. In biological system, lipophilization may contribute to easier penetration of antioxidants through lipid bilayer of cell membranes, which can significantly increase their bioavailability. Despite the evidence supporting a relationship between phenolipid's alkyl chain length and their interaction/affinity with membranes, such a relationship has not been directly evaluated. Investigation of membrane interactions between phenolic and its lipophilic derivative, via SAXS approaches in model membrane liposomes, provide new knowledge about this class of compound with the perspective to be used as substances with maintained or improved biological properties for food, cosmetic and pharmaceutical applications.An X‐ray diffraction analysis highlighted different membrane affinity and nonlinear penetration depth of a series of phenolipids (rosmarinic acid, and its corresponding alkyl esters having 4 carbon (RC4), 8 carbon (RC8), 10 carbon (RC10), and 16 carbon (RC16)). The results seem to perfectly correlate with the phenolipids’ activities (antioxidant and membranes crossing) previously observed both in biological system and in formulated lipid dispersions.
Local deformation‐based design of minimal‐disturbance arm damper for retrofitting steel moment‐resisting frames
Authors: Lavan Oren , Sato Miho , Kurata Masahiro , Lei Zhang 
Published: January 2017

SummaryThis paper presents a design approach for seismic rehabilitation of frames having a beam‐collapse mechanism using a technique termed minimal‐disturbance seismic rehabilitation. This technique pursues enhancing the seismic performance of buildings with the intention of improving the continuity of business. It minimizes obstruction of the visual and physical space of building users and the use of heavy construction equipment and work requiring fire permit (welding/cutting). The developed design approach is simple to use. Yet it leads to designs that limit the beams' plastic rotations to allowable values, while minimizing the number of locations where devices are installed and the devise dimensions. Furthermore, the effectiveness of the design approach and the rehabilitation technique is numerically studied through retrofitting a four‐story steel moment‐resisting frame. Copyright © 2017 John Wiley & Sons, Ltd.
A finite volume scheme preserving extremum principle for convection–diffusion equations on polygonal meshes
Authors: Zhang Qi , Sheng Zhiqiang , Yuan Guangwei 
Published: January 2017

SummaryWe propose a nonlinear finite volume scheme for convection–diffusion equation on polygonal meshes and prove that the discrete solution of the scheme satisfies the discrete extremum principle. The approximation of diffusive flux is based on an adaptive approach of choosing stencil in the construction of discrete normal flux, and the approximation of convection flux is based on the second‐order upwind method with proper slope limiter. Our scheme is locally conservative and has only cell‐centered unknowns. Numerical results show that our scheme can preserve discrete extremum principle and has almost second‐order accuracy. Copyright © 2017 John Wiley & Sons, Ltd.
Rapid vacuum sintering: A novel technique for fabricating fluorapatite ceramic scaffolds for bone tissue engineering
Authors: Denry Isabelle , Goudouri Ourania‐Menti , Harless Jeffrey , Holloway Julie A. 
Published: January 2017

AbstractMacroporous bioceramic scaffolds are often fabricated via the foam replica technique, based on polymeric foam impregnation with a glass slurry, followed by slow heat treatment to allow for drying, polymeric burnout, and sintering of the glass particles. As a consequence, the process is time consuming and complicated by concurrent crystallization of the glass, often leading to incomplete sintering. Our goal was to investigate the effect of heating rate on sintering behavior, architecture, and mechanical properties of fluorapatite‐based glass and glass‐ceramic scaffolds. Glass scaffolds were prepared and sintered by rapid vacuum sintering (RVS) at 785°C under vacuum at a fast heating rate (55°C/min.) or without vacuum at a slow heating rate (2°C/min.). Two additional groups were further crystallized at 775°C/1 h. XRD confirmed the presence of fluorapatite for crystallized scaffolds. All groups presented interconnected porosity with a pore size in the 500 μm range. Scaffolds produced by RVS exhibited an excellent degree of sintering while scaffolds produced by slow sintering were incompletely sintered. The mean compressive strength was significantly higher for the RVS groups (1.52 ± 0.55 and 1.72 ± 0.61 MPa) compared to the slow‐sintered groups (0.54 ± 0.30 and 0.45 ± 0.26 MPa). Meanwhile, the total production time was reduced by more than 12 h by using the RVS technique. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 291–299, 2018.
Reference values for kaolin‐activated thromboelastography in volunteers of Anhui Province in China
Authors: Sun Jun‐Bo , Bian Mao‐Hong , Zhong Tao , Lu Ying‐Yu , Zhu Bang‐Qiang , Wen Hui‐Qin , Hu Hai‐Liang 
Published: January 2017

BackgroundThe assessment of the coagulation status using thromboelastography (TEG) in Chinese population has less been reported. This study aimed to establish reliable reference values for kaolin‐activated TEG in Chinese volunteers.MethodsA total of 1681 Chinese adult individuals were recruited for this study. The reference individuals were stratified by gender and age, and the TEG values were measured on the basis of strict quality control. The 95% reference values were determined using nonparametric statistical methods.ResultsThe sex‐related 95% reference values were reaction time (R):4.2‐8.7 minutes; clotting time (K): 1.2‐3.2 minutes; alpha angle (α): 47.0‐72.3 degree; maximum amplitude (MA): 49.1‐70.5 mm for males, and R: 3.7‐9.0 minutes; K: 1.0‐3.2 minutes; α: 48.4‐74.4 degree; MA: 46.8‐72.4 mm for females. Also, the TEG parameters indicated a relatively more hypercoagulable profile in both female and elder groups.ConclusionsThis study established the reference values for kaolin‐activated TEG in the target Chinese population, which might provide a reference for both clinical and laboratory studies.
Diagnostic performance of procalcitonin, presepsin, and C‐reactive protein in patients with hematological malignancies
Authors: Ebihara Yasuhiro , Kobayashi Kiyoko , Ishida Akaru , Maeda Tomoya , Takahashi Naoki , Taji Yoshitada , Asou Norio , Ikebuchi Kenji 
Published: January 2017

IntroductionInfections represent a major complication of hematological malignancies. C‐reactive protein (CRP) and procalcitonin (PCT) have been used as diagnostic biomarkers of infections, but do not produce definitive findings. Recently, a new biomarker, presepsin, has been used as a diagnostic tool for detecting infections in the fields of emergency and neonatal medicine. However, the usefulness of presepsin for identifying infections in patients with hematological malignancies, including those who develop febrile neutropenia, remains unclear.MethodsIn this study, we retrospectively analyzed the utility of PCT, presepsin, and CRP as biomarkers of infections during 49 febrile episodes that occurred in 28 patients with hematological malignancies.ResultsThe levels of PCT, but not those of CRP or presepsin, were significantly higher in the infection group than in the uninfected group (P<.03), indicating that PCT might be a more sensitive biomarker of infections. No differences in presepsin levels were detected between the patients with and without neutropenia, or between the infected and uninfected patients with neutropenia, indicating that presepsin might have less diagnostic value in patients with neutropenia.ConclusionsWe conclude that PCT might provide additional information and could be used in combination with other biomarkers to detect infections in patients with hematological malignancies.
Land–atmosphere–aerosol coupling in North China during 2000–2013
Authors: Wei Jiangfeng , Jin Qinjian , Yang Zong‐Liang , Zhou Liming 
Published: January 2017

ABSTRACTNorth China is one of the most densely populated regions in the world. To its west, north, and northwest, the world's largest afforestation project has been going on for decades. At the same time, North China has been suffering from air pollution because of its large fossil fuel consumption. Here we show that the changes in land cover and aerosol concentration are coupled with the variations of land surface temperature, cloud cover, and surface solar radiation during the summer 2000–2013. Model experiments show that the interannual variation of aerosol concentration in North China is mainly a result of the varying atmospheric circulation. The increasing vegetation cover due to afforestation has enhanced surface evapotranspiration (ET) and cooled the local surface, and precipitation is observed to be increasing with ET. The model with prescribed increasing vegetation cover can simulate the increasing ET but cannot reproduce the increasing precipitation. Although this may be caused by model biases, the lack of aerosol processes in the model could also be a potential cause.
Biocompatibility, bone healing, and safety evaluation in rabbits with an IlluminOss bone stabilization system
Authors: McSweeney Amanda L. , Zani Brett G. , Baird Rose , Stanley James R. L. , Hayward Alison , Markham Peter M. , Kopia Gregory A. , Edelman Elazer R. , Rabiner Robert 
Published: January 2017

ABSTRACTBone healing, biocompatibility, and safety employing the IlluminOss System (IS), comprised of an inflatable balloon filled with photopolymerizable liquid monomer, was evaluated in New Zealand white rabbits. Successful bone healing and callus remodeling over 6 months was demonstrated radiologically and histologically with IS implants in fenestrated femoral cortices. Biocompatibility was demonstrated with IS implants in brushed, flushed femoral intramedullary spaces, eliciting no adverse, local, or systemic responses and with similar biocompatibility to K‐wires in contralateral femurs up to 1 year post‐implant. Lastly simulated clinical failures demonstrated the safety of IS implants up to 1 year in the presence of liquid or polymerized polymer within the intramedullary space. Polymerized material displayed cortical bone and vasculature effects comparable to mechanical disruption of the endosteum. In the clinically unlikely scenario with no remediation or polymerization, a high dose monomer injection resulted in marked necrosis of cortical bone, as well as associated vasculature, endosteum, and bone marrow. Overall, when polymerized and hardened within bone intramedullary spaces, this light curable monomer system may provide a safe and effective method for fracture stabilization. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2181–2190, 2017.
Non‐destructive assessment of grapevine water status in the field using a portable NIR spectrophotometer
Authors: Tardaguila Javier , Fernández‐Novales Juan , Gutiérrez Salvador , Diago Maria Paz 
Published: January 2017

AbstractBACKGROUNDUntil now, the majority of methods employed to assess grapevine water status have been destructive, time‐intensive, costly and provide information of a limited number of samples, thus the ability of revealing within‐field water status variability is reduced. The goal of this work was to evaluate the capability of non‐invasive, portable near infrared (NIR) spectroscopy acquired in the field, to assess the grapevine water status in diverse varieties, grown under different environmental conditions, in a fast and reliable way. The research was conducted 2 weeks before harvest in 2012, in two commercial vineyards, planted with eight different varieties. Spectral measurements were acquired in the field on the adaxial and abaxial sides of 160 individual leaves (20 leaves per variety) using a commercially available handheld spectrophotometer (1600–2400 nm).RESULTSPrincipal component analysis (PCA) and modified partial least squares (MPLS) were used to interpret the spectra and to develop reliable prediction models for stem water potential (Ψs) (cross‐validation correlation coefficient (rcv) ranged from 0.77 to 0.93, and standard error of cross validation (SECV) ranged from 0.10 to 0.23), and leaf relative water content (RWC) (rcv ranged from 0.66 to 0.81, and SECV between 1.93 and 3.20). The performance differences between models built from abaxial and adaxial‐acquired spectra is also discussed.CONCLUSIONSThe capability of non‐invasive NIR spectroscopy to reliably assess the grapevine water status under field conditions was proved. This technique can be a suitable and promising tool to appraise within‐field variability of plant water status, helpful to define optimised irrigation strategies in the wine industry. © 2017 Society of Chemical Industry
Gelation of barramundi (Lates calcarifer) minced muscle as affected by pressure and thermal treatments at low salt concentration
Authors: Truong Binh Q , Buckow Roman , Nguyen Minh H , Furst John 
Published: January 2017

AbstractBACKGROUNDBarramundi minced muscle with salt 10 g kg−1 and 20 g kg−1 added is gelled by different combinations of pressurisation (300, 400 and 500 MPa at 4 °C for 10 min), cooking (0.1 MPa, 90 °C for 30 min) and setting (0.1 MPa, 50 °C for 2 h) to improve mechanical properties of barramundi gels and reduce salt added to barramundi gels.RESULTSAt the low salt concentration of 10 g kg−1, pressurisation prior to cooking (P–C) treatment induced barramundi gels with comparable mechanical properties and water‐holding capacity to those of conventional heat induced (HI) gels with 20 g kg−1 added salt. At salt concentration of 20 g kg−1, pressurisation prior to setting (P–S) and P–C gels exhibited higher mechanical properties and water‐holding capacity as compared to HI gels. Scanning electron microscopy images showed a smooth and dense microstructure of P–C and P–S gels whereas the microstructure of HI gels is rough and less compact.CONCLUSIONSP–C treatment can reduce salt concentration added to barramundi gels to 10 g kg−1. P–S and P–C treatment can result in higher mechanical and functional properties of barramundi gels at conventional salt concentration (20 g kg−1) as compared to HI gels. © 2017 Society of Chemical Industry
Postoperative mortality following multi‐modality therapy for pancreatic cancer: Analysis of the SEER‐Medicare data
Authors: Nayar Preethy , Chandak Aastha , Gupta Niodita , Yu Fang , Qiu Fang , Ganti Apar Kishor , Are Chandrakanth 
Published: January 2017

Background and ObjectivesThe objective of this study was to examine post‐operative mortality for elderly pancreatic cancer patients treated with multi‐modality therapy.MethodsSurveillance Epidemiology and End Results (SEER) Medicare linked data were used to examine differences in mortality between patients who underwent pancreatectomy alone and those who had early (within 12 weeks) and late (after 12 weeks) adjuvant therapy (chemotherapy and/or radiotherapy).ResultsAmong 4,105 patients who underwent pancreatectomy between 1991 and 2008, 1‐year mortality (Odds Ratio [OR] = 0.71; P‐value = 0.000; 95% Confidence Interval [CI]: 0.60–0.85) and 6‐month mortality (OR = 0.44; P‐value = 0.000; 95%CI: 0.35–0.53) following pancreatectomy were significantly lower in the group that underwent pancreatectomy with early adjuvant therapy. Late adjuvant therapy group also had lower 1 year (OR = 0.51; P‐value = 0.000; 95%CI: 0.43–0.61) and 6 months (OR = 0.14; P‐value = 0.000; 95%CI: 0.10–0.17) mortality, compared to surgery alone.ConclusionsPost‐operative outcomes were better for patients treated with surgery with adjuvant therapy, with the late adjuvant therapy group having the best outcomes (lowest odds of 6 month and 1‐year mortality following surgery). J. Surg. Oncol. 2017;115:158–163. © 2017 Wiley Periodicals, Inc.