bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An Algorithm for Generalized Anxiety Disorder
Authors: Abejuela Harmony Raylen , Osser David N. 
Published: July 2016

Abstract
This revision of previous algorithms for the pharmacotherapy of generalized anxiety disorder was developed by the Psychopharmacology Algorithm Project at the Harvard South Shore Program. Algorithms from 1999 and 2010 and associated references were reevaluated. Newer studies and reviews published from 2008–14 were obtained from PubMed and analyzed with a focus on their potential to justify changes in the recommendations. Exceptions to the main algorithm for special patient populations, such as women of childbearing potential, pregnant women, the elderly, and those with common medical and psychiatric comorbidities, were considered. Selective serotonin reuptake inhibitors (SSRIs) are still the basic first-line medication. Early alternatives include duloxetine, buspirone, hydroxyzine, pregabalin, or bupropion, in that order. If response is inadequate, then the second recommendation is to try a different SSRI. Additional alternatives now include benzodiazepines, venlafaxine, kava, and agomelatine. If the response to the second SSRI is unsatisfactory, then the recommendation is to try a serotonin-norepinephrine reuptake inhibitor (SNRI). Other alternatives to SSRIs and SNRIs for treatment-resistant or treatment-intolerant patients include tricyclic antidepressants, second-generation antipsychotics, and valproate. This revision of the GAD algorithm responds to issues raised by new treatments under development (such as pregabalin) and organizes the evidence systematically for practical clinical application.
Separating Fact from Fiction: An Empirical Examination of Six Myths About Dissociative Identity Disorder
Authors: Brand Bethany L. , Sar Vedat , Stavropoulos Pam , Krüger Christa , Korzekwa Marilyn , Martínez-Taboas Alfonso , Middleton Warwick 
Published: July 2016

Abstract
Dissociative identity disorder (DID) is a complex, posttraumatic, developmental disorder for which we now, after four decades of research, have an authoritative research base, but a number of misconceptualizations and myths about the disorder remain, compromising both patient care and research. This article examines the empirical literature pertaining to recurrently expressed beliefs regarding DID: (1) belief that DID is a fad, (2) belief that DID is primarily diagnosed in North America by DID experts who overdiagnose the disorder, (3) belief that DID is rare, (4) belief that DID is an iatrogenic, rather than trauma-based, disorder, (5) belief that DID is the same entity as borderline personality disorder, and (6) belief that DID treatment is harmful to patients. The absence of research to substantiate these beliefs, as well as the existence of a body of research that refutes them, confirms their mythical status. Clinicians who accept these myths as facts are unlikely to carefully assess for dissociation. Accurate diagnoses are critical for appropriate treatment planning. If DID is not targeted in treatment, it does not appear to resolve. The myths we have highlighted may also impede research about DID. The cost of ignorance about DID is high not only for individual patients but for the whole support system in which they reside. Empirically derived knowledge about DID has replaced outdated myths. Vigorous dissemination of the knowledge base about this complex disorder is warranted.
Negative Consequences of Family Caregiving for Veterans With PTSD and Dementia
Authors: Pinciotti Caitlin M. , Bass David M. , McCarthy Catherine A. , Judge Katherine S. , Wilson Nancy L. , Morgan Robert O. , Snow A. Lynn , Kunik Mark E. 
Published: July 2016

Abstract
Recent research shows veterans with posttraumatic stress disorder (PTSD) are twice as likely as other veterans to develop dementia. However, no studies to date have examined the impact of co-existing PTSD and dementia on family caregivers, who provide the majority of care to these veterans. Using the Stress Process Model, the current investigation explored the similarities and differences in psychosocial, health, and service use outcomes among caregivers assisting veterans with PTSD and dementia compared with caregivers assisting veterans with dementia only. Caregivers of veterans with PTSD and dementia indicated that their relative exhibited more difficult behavior symptoms and used more community services. These caregivers also reported more difficulties understanding veterans’ memory problems and more physical strain. Together, results suggested caregivers of veterans with both PTSD and dementia were at greater risk of negative caregiving consequences. Implications and suggestions for future research are discussed.
Incidentally Detected Lithopedion in an 87-Year-Old Lady
Authors: Gürler Ahmet Selçuk , Daş Taner , Gitmiş Gökhan , Apaydin Nedim , Kara Erdoğan , Özdemirel Rifat Özgür , Çelik Safa , Özdeş Emel , Sezer Yiğit 
Published: July 2016

Abstract
A lithopedion is a rare complication of pregnancy that occurs when a fetus in an intraabdominal location dies, and it is too large to be reabsorbed by the body. The case was an 87-year-old woman, and she was transferred to the morgue department in April 2014 to determine the cause of death. During autopsy, an intraabdominally located calcified dead fetus and a 12-cm diameter calcified cyst in the right ovary were incidentally detected. It was aged 25 to 29 weeks (according to femur and humerus measurements) with a size of 12.5 × 8 × 5 cm and a weight of 227 g. According to investigation reports, her husband died in 1990, and she had 3 deliveries, the most recent of which was in 1946. Because the menopause age of the case was not exactly known, the retention time of the lithopedion was supposed to be 24 to 68 years according to the date of the most recent pregnancy and the date of her spouse's death. It is the first case that has been incidentally detected and identified during an autopsy in Turkey and also one of the oldest cases in the literature.
Comparison of Antibodies for Immunohistochemistry-based Detection of HER3 in Breast Cancer
Authors: Luhtala Satu , Staff Synnöve , Barok Mark , Tanner Minna , Isola Jorma 
Published: July 2016

Background:
Growth factor receptor HER3 (ErbB3) lacks standardized immunohistochemistry (IHC)-based methods for formalin-fixed paraffin-embedded (FFPE) tissue samples. We compared 4 different anti-HER3 antibodies to explain the differences found in the staining results reported in the literature.

Materials and Methods:
Four commercial HER3 antibodies were tested on FFPE samples including mouse monoclonal antibody clones, DAK-H3-IC and RTJ1, rabbit monoclonal antibody clone SP71, and rabbit polyclonal antibody (SAB4500793). Membranous and cytoplasmic staining patterns were analyzed and scored as 0, 1+, or 2+ according to the intensity of the staining and completeness of membranous and cytoplasmic staining. A large collection of HER2-amplified breast cancers (n=177) was stained with the best performing HER3 antibody. The breast cancer cell line, MDA-453, and human prostate tissue were used as positive controls. IHC results were confirmed by analysis of flow cytometry performed on breast cancer cell lines. Staining results of FFPE samples were compared with samples fixed with an epitope-sensitive fixative (PAXgene).

Results:
Clear circumferential cell membrane staining was found only with the HER3 antibody clone DAK-H3-IC. Other antibodies (RTJ1, SP71, and polyclonal) yielded uncertain and nonreproducible staining results. In addition to cell membrane staining, DAK-H3-IC was also localized to the cytoplasm, but no nuclear staining was observed. In HER2-amplified breast cancers, 80% of samples were classified as 1+ or 2+ according to the HER3 staining on the cell membrane. The results from FFPE cell line samples were comparable to those obtained from unfixed cells in flow cytometry. IHC conducted on FFPE samples and on PAXgene-fixed samples showed equivalent results.

Conclusions:
We conclude that IHC with the monoclonal antibody, DAK-H3-IC, on FFPE samples is a reliable staining method for use in translational research. Assessment of membranous HER3 expression may be clinically relevant in selecting patients who may most benefit from pertuzumab or other novel anti-HER3 therapies.
Preparation With Web-Based Observational Practice Improves Efficiency of Simulation-Based Mastery Learning
Authors: Cheung Jeffrey J.H. , Koh Jansen , Brett Clare , Bägli Darius J. , Kapralos Bill , Dubrowski Adam 
Published: July 2016

Introduction
Our current understanding of what results in effective simulation-based training is restricted to the physical practice and debriefing stages, with little attention paid to the earliest stage: how learners are prepared for these experiences. This study explored the utility of Web-based observational practice (OP) —featuring combinations of reading materials (RMs), OP, and collaboration— to prepare novice medical students for a simulation-based mastery learning (SBML) workshop in central venous catheterization.

Methods
Thirty medical students were randomized into the following 3 groups differing in their preparatory materials for a SBML workshop in central venous catheterization: a control group with RMs only, a group with Web-based groups including individual OP, and collaborative OP (COP) groups in addition to RM. Preparation occurred 1 week before the SBML workshop, followed by a retention test 1-week afterward. The impact on the learning efficiency was measured by time to completion (TTC) of the SBML workshop. Web site preparation behavior data were also collected.

Results
Web-based groups demonstrated significantly lower TTC when compared with the RM group, (P = 0.038, d = 0.74). Although no differences were found between any group performances at retention, the COP group spent significantly more time and produced more elaborate answers, than the OP group on an OP activity during preparation.

Discussion
When preparing for SBML, Web-based OP is superior to reading materials alone; however, COP may be an important motivational factor to increase learner engagement with instructional materials. Taken together, Web-based preparation and, specifically, OP may be an important consideration in optimizing simulation instructional design.
Simulated Disaster Day
Authors: Livingston Laura L. , West Courtney A. , Livingston Jerry L. , Landry Karen A. , Watzak Bree C. , Graham Lori L. 
Published: July 2016

Summary Statement
Disaster Day is a simulation event that began in the College of Nursing and has increased exponentially in size and popularity for the last 8 years. The evolution has been the direct result of reflective practice and dedicated leadership in the form of students, faculty, and administration. Its development and expansion into a robust interprofessional education activity are noteworthy because it gives health care professions students an opportunity to work in teams to provide care in a disaster setting. The “authentic” learning situation has enhanced student knowledge of roles and responsibilities and seems to increase collaborative efforts with other disciplines. The lessons learned and modifications made in our Disaster Day planning, implementation, and evaluation processes are shared in an effort to facilitate best practices for other institutions interested in a similar activity.
Mating success and body condition not related to foraging specializations in male fur seals
Authors: Kernaléguen L. , Cherel Y. , Guinet C. , Arnould J. P. Y. 
Published: July 2016

Individual specialization is widespread among wild populations. While its fitness consequences are central in predicting the ecological and evolutionary trajectories of populations, they remain poorly understood. Long-term individual foraging specializations occur in male Antarctic (
Arctocephalus gazella
) and Australian (
A. pusillus doriferus
) fur seals. Strong selective pressure is expected in these highly dimorphic and polygynous species, raising the question of the fitness payoffs associated with different foraging strategies. We investigated the relationship between individual isotopic niche (a proxy of foraging specialization), body size and condition, and an index of reproductive success (harem size) in territorial males. Individuals varied greatly in their skin and fur isotopic values reflecting a range of foraging strategies within the two populations. However, in both species, isotopic niche was not correlated to body size, condition or mating success (
R
2
/
ρ
< 0.06). Furthermore, no foraging niche was predominant in either species, which would have indicated a substantial long-term fitness benefit of a particular strategy via a higher survival rate. These results suggest that the fitness consequences of a foraging strategy depend not only on the quality of prey and feeding habitat but also on an individual's hunting efficiency and skills.
Potent Protection Against H5N1 and H7N9 Influenza via Childhood Hemagglutinin Imprinting
Authors: Gostic Katelyn M. , Ambrose Monique , Worobey Michae , Lloyd-Smith James O. 
Published: July 2016

AbstractTwo zoonotic influenza A viruses (IAV) of global concern, H5N1 and H7N9, exhibit puzzling differences in age distribution of human cases. Previous explanations cannot fully account for these patterns. We analyze data from all known human cases of H5N1 and H7N9 and show that an individual’s first IAV infection confers lifelong protection against severe disease from novel hemagglutinin (HA) subtypes of the same phylogenetic group. Statistical modeling reveals protective HA imprinting to be the crucial explanatory factor, providing 75% protection against severe infection and 80% protection against death for both H5N1 and H7N9. Our results enable us to predict age distributions of severe disease for future pandemics and to demonstrate that a novel strain’s pandemic potential increases yearly when a group-mismatched HA subtype dominates seasonal influenza circulation. These findings open new frontiers for rational pandemic risk assessment.
A simple proposal for the publication of journal citation distributions
Authors: Larivière Vincent , Kiermer Véronique , MacCallum Catriona J. , McNutt Marcia , Patterson Mark , Pulverer Bernd , Swaminathan Sowmya , Taylor Stuart , Curry Stephen 
Published: July 2016

AbstractAlthough the Journal Impact Factor (JIF) is widely acknowledged to be a poor indicator of the quality of individual papers, it is used routinely to evaluate research and researchers. Here, we present a simple method for generating the citation distributions that underlie JIFs. Application of this straightforward protocol reveals the full extent of the skew of these distributions and the variation in citations received by published papers that is characteristic of all scientific journals. Although there are differences among journals across the spectrum of JIFs, the citation distributions overlap extensively, demonstrating that the citation performance of individual papers cannot be inferred from the JIF. We propose that this methodology be adopted by all journals as a move to greater transparency, one that should help to refocus attention on individual pieces of work and counter the inappropriate usage of JIFs during the process of research assessment.
Sub-millisecond optogenetic control of neuronal firing with two-photon holographic photoactivation of Chronos
Authors: Ronzitti E. , Conti R. , Papagiakoumou E. , Tanese D. , Zampini V. , Chaigneau E. , Foust A.J. , Klapoetke N. , Boyden E.S. , Emiliani V. 
Published: July 2016

ABSTRACTOptogenetic neuronal network manipulation promises to at last unravel a long-standing mystery in neuroscience: how does microcircuit activity causally relate to behavioral and pathological states? The challenge to evoke spikes with high spatial and temporal complexity necessitates further joint development of light-delivery approaches and custom opsins. Two-photon scanning and parallel illumination strategies applied to ChR2- and C1V1-expressing neurons demonstrated reliable, in-depth generation of action potentials bothin-vitroandin-vivo, but thus far lack the temporal precision necessary to induce precisely timed spiking events. Here, we show that efficient current integration enabled by two-photon holographic amplified laser illumination of Chronos, a highly light-sensitive and fast opsin, can evoke spikes with submillisecond precision and repeated firing up to 100 Hz. These results pave the way for optogenetic manipulation with the spatial and temporal sophistication necessary to mimic natural microcircuit activity.
Autism research dynamic through ontology-based text mining
Authors: Macedoni Luksic Marta , Urbancic Tanja , Petric Ingrid , Cestnik Bojan 
Published: July 2016

Purpose
– The increase of prevalence of autism spectrum disorders (ASD) has been accompanied by much new research. The amount and the speed of growth of scientific information available online have strongly influenced the way of work in the research community which calls for new methods and tools to support it. The purpose of this paper is to present ontology-based text mining in the field of autism trend analysis that may help to understand the broader picture of the disorder since its discovery.

Design/methodology/approach
– The data sets consisted of abstracts of more than 18,000 articles on ASD published from 1943 to the end of 2012 found in MEDLINE and of the documents’ titles for all those articles where the abstracts were not available.

Findings
– In this way, the authors demonstrated a steeper exponential curve of ASD publications compared with all publications in MEDLINE. In addition, the main research topics over time were identified using the “open discovery” approach. Finally, the relationship between a priori setting up research topics including communication, genetics, environmental risk factors, vaccination and adulthood were revealed.

Originality/value
– Using ontology-based text mining the authors were able to identify the main research topics in the field of autism during the time, as well as to show the dynamics of some research topics as a priori setting up. The computerised methodology that was used allowed the authors to analyse a much larger quantity of information, saving time and manual work.
How useful are the Adult Asperger Assessment and AQ-10 within an adult clinical population of all intellectual abilities?
Authors: Kenny Hayley , Stansfield Alison Jane 
Published: July 2016

Purpose
– The Adult Asperger Assessment (AAA) was designed to be a screening tool to identify adults with Asperger syndrome and/or high-functioning autism. The AAA includes three questionnaires; the Autism Quotient (AQ), the Empathy Quotient (EQ) and the Relatives Questionnaire (RQ). The Autism Quotient-10 (AQ-10) was designed to be a “red flag” for healthcare professionals considering referral for ASD assessment. The purpose of this paper is to determine the usefulness of the AAA and AQ-10 as part of an adult autism diagnostic pathway that includes patients of all intellectual ability.

Design/methodology/approach
– Results were obtained for all patients who had received a clinical decision at Leeds Autism Diagnostic Service, which is a service that assesses patients of all intellectual ability, during 2015, n=214. Of these 132 were included in the analysis, 77 patients were excluded for not completing the AAA and four were excluded for not receiving a clinical decision.

Findings
– Results suggest that patients diagnosed with ASD without intellectual disabilities score on average 35 on the AQ, 17 on the EQ and 20 on the RQ. Those not diagnosed with ASD score on average 33 on the AQ, 22 on the EQ and 15 on the RQ. Patients with intellectual disabilities, scores are lower on the AQ, and higher on the EQ and RQ than those without intellectual disabilities. These results are the same regardless of diagnosis of ASD. The RQ is the only questionnaire to result in a significant difference between those diagnosed and not diagnosed. Results suggest that the AQ-10 is not useful in this clinical population.

Research limitations/implications
– This study was undertaken as part of a service development improvement process. The specific demographics of this clinical population may have influenced the findings. The process will need to be repeated to ensure that the results are consistent across time and increased sample size. The population of patients with an intellectual disability is small, further studies into the use of the AAA or the design of other intellectual disability specific screening tools should be pursued. It is of note that the AAA was never intended for use within an intellectual disability population.

Originality/value
– This is an original paper as it will be the first to consider the usefulness of each of the aspects of the AAA collectively. It will be the first to assess: the AQ-10 alongside the AAA, the usefulness of the AAA regardless of intellectual ability and the usefulness of the AAA within a clinical population by using the diagnostic outcome as the benchmark of the usefulness of the AAA scores. This paper will only be discussing the scores generated by the AAA, and the correlation of these scores with a diagnosis.
Autistic spectrum disorders, personality disorder and offending in a transgender patient: clinical considerations, diagnostic challenges and treatment responses
Authors: Baker Philip , Shweikh Eman 
Published: July 2016

Purpose
– The case of a woman with a history of offending and prolonged imprisonment is given. The purpose of this paper is to explore the complex interplay between diagnoses of autistic spectrum disorder (ASD), personality disorder and gender dysphoria. A discussion on useful and less useful treatment approaches follows, given the unusual and complex clinical presentation.

Design/methodology/approach
– This is a case report with a summary of the background to this under-researched area.

Findings
– The way in which the diagnostic picture clarified over time is explained. The difficulties in accurately diagnosing are put forward and strategies to address this are suggested. Successful treatment of unusual clinical problems may require highly individualised care within generic services.

Originality/value
– The authors know of no similar case reports in the published literature. The clinical associations between ASDs, personality disorders and gender dysphoria, in forensic mental health populations, appears to be unexplored in the literature.