bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimum information for reporting on the TEER (trans-epithelial/endothelial electrical resistance) assay (MIRTA)
Authors: Sharma Monita , Huber Erin , Arnesdotter Emma , Behrsing Holger P. , Bettmann Adam , Brandwein David , Constant Samuel , Date Rahul , Deshpande Abhay , Fabian Eric , Gupta Amit , Gutierrez Robert , Gutleb Arno C. , Hargrove Marie M. , Hollings Michael , Hutter Victoria , Jarabek Annie M. , Kaluzhny Yulia , Landsiedel Robert , Milchak Lawrence , Moyer Robert A. , Murray Jessica R. , Page Kathryn , Patel Manish , Pearson Stephanie N. , Petersen Elijah J. , Reinke Emily , Roldan Nuria , Roper Clive , Scaglione Jamie B. , Settivari Raja S. , Stucki Andreas O. , Verstraelen Sandra , Wallace Joanne L. , McCullough Shaun , Clippinger Amy J. 
Published: October 2024

Abstract
Standard information reporting helps to ensure that assay conditions and data are consistently reported and to facilitate inter-laboratory comparisons. Here, we present recommendations on minimum information for reporting on the TEER (trans-epithelial/endothelial electrical resistance) assay (MIRTA). The TEER assay is extensively used to evaluate the health of an epithelial/endothelial cell culture model and as an indicator of the potential toxicity of a test substance. This publication is the result of an international collaboration─called the RespTox (Respiratory Toxicity) Collaborative─through which twelve laboratories shared their protocols for assessing the barrier function of respiratory epithelial cells using the TEER assay following exposure to substances. The protocols from each laboratory were reviewed to identify general steps for performing the TEER assay, interlaboratory differences between steps, the rationale for differences, whether these differences impact results or cross-laboratory comparisons between TEER measurements. While the MIRTA recommendations are focused on respiratory epithelial cell systems, these recommendations can be adapted for other cell systems that form barriers. The use of these recommendations will support data transparency and reproducibility, reduce challenges in data interpretation, enable cross-laboratory comparisons, help assess study quality, and facilitate the incorporation of the TEER assay into national and international testing guidance.
Oxytocin differentially modulates reward system responses to social and non-social incentives
Authors: Thurston Matthew D. , Ericksen Lauren C. , Jacobson Maci M. , Bustamante Allison , Koppelmans Vincent , Mickey Brian J. , Love Tiffany M. 
Published: October 2024

Abstract

Rationale
Oxytocin has been shown to modulate behavior related to processing of monetary incentives and to regulate social and reproductive behavior, yet little is known about how oxytocin differentially influences neural responses to social and non-social incentives.

Objectives
We aimed to evaluate the effects of oxytocin administration on behavioral and neural responses to social and monetary incentives.

Methods
Twenty-eight healthy adults (age 18–45 years) performed both monetary and social incentive tasks during blood oxygenation level dependent (BOLD) imaging. Intranasal oxytocin or placebo was administered before each scan using a double blind, randomized, cross-over design. Task performance and self-reported motivation and mood states were collected. Time-series analysis was conducted to assess the influence of oxytocin on the hemodynamic response in the ventral tegmental area and substantia nigra (VTA/SN) and nucleus accumbens (NAc).

Results
Oxytocin demonstrated a multifaceted effect on VTA/SN and NAc when processing reward incentives, with it increasing BOLD response in VTA/SN and decreasing BOLD response in NAc during social incentive anticipation. A reversal of this was shown with decreased BOLD responses in the VTA/SN and increased BOLD response in the NAc during monetary incentive anticipation.

Conclusions
Our findings suggest a more nuanced purpose of oxytocin when evaluating reward incentive decision making. It is possible that while oxytocin does increase salience to rewards, that it is more important for cognitive control when determining short-term versus long-term benefits in rewards. Future studies should more closely examine the relationship between oxytocin and delay discounting.
Fusarium sp. Strain K-23 Alleviates Salt Stress in Arabidopsis thaliana Through its Root Hair Growth-Promoting Effect
Authors: Onejeme Francis C. , González Ortega-Villaizán Adrián , Rodríguez-Dobreva Estefanía , Topel Prieto Basha , Patel Manish K. , Guendouzi Selma , Reddy Priya Y. N. , Lopez Leonel E. , Estevez José M. , Nataraja Karaba N. , Shaanker R. Uma , Benito Begoña , Vicente-Carbajosa Jesús , Oelmüller Ralf , Pollmann Stephan 
Published: October 2024

AbstractSoil salinity is a significant abiotic stress factor that impedes plant growth and crop yield, particularly in arid and semi-arid regions. Recent reports indicate that 8.7% of soils globally and 20–50% of irrigated soils across all continents are affected by salt. This phenomenon jeopardizes the food security of more than 1.5 billion people worldwide. Numerous studies have elucidated the beneficial effects of diverse microbes on plant abiotic stress tolerance. In this study, we report on an observed molecular mechanism involved in the enhanced salt tolerance of Arabidopsis plants co-cultivated with the Fusarium sp. strain K-23. Employing a combination of transcriptomics, phenomics, reverse genetics, and live cell imaging, we elucidated the intricacies of biological processes that influence root growth in the interaction between A. thaliana and the fungus. Moreover, our research corroborated the beneficial effect of the fungus under salt-stress conditions for Arabidopsis and highlighted notable differences compared to previous studies. We utilized an RNA-seq approach to identify biological processes triggered in Arabidopsis roots that interact with K-23, resulting in increased salt tolerance. These experiments necessitated a more comprehensive investigation into the fungal influence on root hair development and elucidated that induced root hair growth was a prerequisite for the enhanced salt stress tolerance conferred by the fungus. Furthermore, we demonstrate that the fungus induces the expression of the NAC transcription factor JUNGBRUNNEN 1 (JUB1). Elevated expression of JUB1 leads to repression of gibberellin biosynthesis, which, in turn, contributes to sustained root hair growth under salt stress conditions, which typically suppresses root hair growth substantially.
Studying Hierarchical Latent Structures in Heterogeneous Populations with Missing Information
Authors: Greselin Francesca , Zaccaria Giorgia 
Published: October 2024

AbstractAn ultrametric Gaussian mixture model is a powerful tool for modeling hierarchical relationships among latent concepts, making it ideal for studying complex phenomena in diverse and potentially heterogeneous populations. However, in many cases, only an incomplete set of observations is available on the phenomenon under study. To address this issue, we propose MissUGMM, an ultrametric Gaussian mixture model which takes into account the missing at random mechanism for the unobserved values. Our approach is estimated using the expectation-maximization algorithm and achieves favorable results in comparison to other existing mixture models in simulations conducted with synthetic and benchmark data sets, even without a theorized ultrametric structure underlying the data. Furthermore, MissUGMM is applied to a real-world problem for exploring the sustainable development of cities across countries starting from incomplete information provided by municipalities. Overall, our results demonstrate that MissUGMM is a powerful and versatile model in dealing with missing data and is applicable to a broader range of real-world problems.
Impact of tongue base mucosectomy on quality-of-life outcomes: systematic review and single-centre experience
Authors: Scholfield Daniel W. , Williamson Andrew J. , Cunning Nina , Awad Zaid 
Published: October 2024

Abstract

Purpose
Tongue base mucosectomy (TBM) is a well-established procedure in investigating cervical squamous cell carcinoma of occult primary. However, its risks have not been balanced against its benefits with validated tools.

Methods
A systematic literature review was conducted for reported complications and quality-of-life outcomes following TBM. The complications and quality-of-life outcomes following TBM at our institution are then reported using objective metrics and validated assessment tools, including Performance Status Scale for Head and Neck Cancer Patients (PSS-HNS), University of Washington Quality-of-life Questionnaire (UW-QOL) and M. D. Anderson Dysphagia Inventory (MDADI).

Results
Eighteen studies met the criteria for inclusion in the systematic review. Of these, 9 addressed swallowing outcomes described in text, without using validated assessment tools. No studies reported taste, speech and pain outcomes after TBM. Post-operative bleeding was not consistently reported. 20 patients underwent robotic TBM at our institution between 2017 and 2023. The primary tumour was identified in 50% (10/20) of cases. The median time to commencing soft diet and median time of NG feeding was 0 days. The median return to normalcy of diet score was 95. Median post-treatment UW-QOL pain and swallowing scores were 100 and 70 respectively. The median speech score was 100, saliva 70, and taste 70. The median normalised MDADI scores were: global 80; emotional 67; functional 80 and physical 65.

Conclusions
Validated assessment tools better inform patients about treatment options and can help compare post-TBM results across institutions. Our data demonstrates that TBM patients have a functional post-operative swallow, are pain and gastrostomy free, even after adjuvant treatment. Routine post-operative insertion of NG tube is not necessary.
Does the ChOLE classification relate to the duration of surgery?
Authors: Esser Julia , Broicher Leonie , Mayer Marcel , Eckel Hans , Jansen Louis , Nobis Anne , Faste Frederik , Klussmann Jens Peter , Luers Jan Christoffer 
Published: October 2024

Abstract

Introduction
Cholesteatoma, a challenging entity in otologic surgery, necessitates a standardized classification system for effective communication among healthcare providers and consistent reporting of surgical outcomes. The ChOLE Classification System, introduced by Linder et al., stages cholesteatoma based on extension (Ch), ossicular chain status (O), life-threatening complications (L), and Eustachian tube function and mastoid pneumatization (E).

Methods
We classified 199 patients who underwent cholesteatoma surgery between 2019 and 2023 in our University Hospital to assess the distribution of the ChOLE stages and to examine the relationship between the ChOLE stages and the duration of surgery.

Results
This study revealed significant correlations between the ChOLE stage and respective subgroups of the classification and duration of surgery and thus complexity of procedure.

Conclusion
Despite limitations, the ChOLE classification proves valuable in predicting surgical complexity and optimizing patient care. Further research is warranted to validate these findings and enhance cholesteatoma management strategies.
A generic formulation of anisotropic thermo-elastoviscoplasticity at finite deformations for finite element codes
Authors: Abatour Mohamed , Ammar Kais , Forest Samuel , Ovalle Cristian , Osipov Nikolay , Quilici Stéphane 
Published: October 2024

AbstractMost commercial Finite Element codes rely on hypo-elastoviscoplastic constitutive equations for structural computations at large deformations. Such formulations are known to suffer from physical and thermodynamical flaws but their versatility and ease of implementation made them ubiquitous. The paper presents an alternative systematic and thermodynamically consistent extension of anisotropic thermo-elastoviscoplastic constitutive equations at finite strain. The formulation is based on the well–known multiplicative decomposition of the deformation gradient into a thermoelastic and an inelastic part. This decomposition relies on Mandel’s isoclinic intermediate configuration. The present framework covers a wide range of multi-mechanism elastoplastic models so that it can advantageously replace the constitutive part of existing codes. The choice of a suitable hyperelastic potential, hardening variables and anisotropy evolution laws are discussed. The concept of plastic spin is used and can be either derived from general representation theorems or obtained from the normality rule. The effect of the plastic spin is discussed in the light of examples involving anisotropic plasticity. The response of the proposed formulation is compared to hypoelastic models in the case of several structural applications. The implementation of this methodology in a commercial FE object-oriented code is detailed. We show how to extend readily a wide range of small strain nonlinear constitutive models to finite deformations. The paper contains original features such as multimechanism based inelastic contributions, a Mandel-stress tensor based nonlinear kinematic hardening rule containing dynamic and static recovery terms, and a study of lattice rotation in single crystalline volume elements and turbine blades. The implementation is proved to be competitive with respect to existing hypo-elastoviscoplastic formulations in terms of CPU time.
p-elements in profinite groups
Authors: Lucchini Andrea , Otmen Nowras 
Published: October 2024

AbstractWe investigate some properties of the p-elements of a profinite group G. We prove that if p is odd and the probability that a randomly chosen element of G is a p-element is positive, then G contains an open prosolvable subgroup. By contrast, there exist groups that are not virtually prosolvable but in which the probability that a randomly chosen element of G is a 2-element is arbitrarily close to 1. We prove also that if a profinite group G has the property that, for every p-element x, it is positive the probability that a randomly chosen element y of G generates with x a pro-p group, then G contains an open pro-p subgroup.
One-stage scalp reconstruction using single-layer dermal regeneration template and split-thickness skin graft: a case series
Authors: Boschetti Ciro Emiliano , Lo Giudice Giorgio , Staglianò Samuel , Pollice Annalisa , Guida David , Magliulo Roberta , Colella Giuseppe , Chirico Fabrizio , Santagata Mario 
Published: October 2024

Abstract
Purpose
Scalp full-thickness defects reconstruction following the resection of skin carcinoma poses significant challenges due to scalp anatomy complexity and limited vascularity. Despite various techniques available, including tissue expansion and local flaps, no single method stands as the gold standard. Moreover, cases requiring adjuvant radiotherapy further complicate reconstruction, demanding durable solutions. This study explores the efficacy of Integra® Dermal Regeneration Template Single Layer (Integra DRTSL) followed by split-thickness skin grafting (STSG) in one-stage scalp reconstruction post oncologic resection.

Methods
A retrospective analysis was conducted on patients undergoing this procedure from January 2020 to October 2023. Surgical outcomes, including graft take rates, complications, and adjuvant therapy tolerability, were assessed.

Results
Results demonstrated successful reconstruction in the majority of cases, with a complete graft take rate of 77% and minimal complications. Notably, the single-stage approach facilitated timely initiation of adjuvant therapy, crucial for oncologic management. Healing times were notably reduced (< 60 days), enabling early radiotherapy commencement. No local recurrences were observed during the 16-month follow-up.

Conclusion
The use of Integra DRTSL with STSG in one-stage reconstruction presents a promising alternative, offering optimal cosmetic and functional outcomes with low complication rates. This approach streamlines the reconstruction process, ensuring timely adjuvant therapy initiation and maximizing patient outcomes, especially in the context of scalp cutaneous tumors requiring radiotherapy.

Clinical trial number
This research was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of University of Campania “Luigi Vanvitelli” (protocol code N. 0013333, 29 April 2021)
Unveiling blind spots in consulting firms’ disseminating discourse on digital transformation
Authors: Monod Emmanuel , Korotkova Nataliia , Khalil Sabine , Meythaler Antonia , Joyce Elisabeth 
Published: October 2024

AbstractLeading management consulting firms serve as key influencers in disseminating fashionable management ideas and aiding organizations through their change initiatives. Organizations often seek guidance from these firms to implement the management idea of digital transformation (DT), enticed by the potential benefits this idea promises. This study examines the reports of six leading management consulting firms to assess how they shape the disseminating discourse on DT. Applying the performance-structure-technology framework, we unveil several blind spots in the DT consulting discourse. Our document analyses reveal that leading management consulting firms, in their discourse on DT, neglect comprehensive strategic alignments in the form of people, competitive context, and technological methods and structures. This study contributes to the literature on change management, management ideas, and the broader information systems literature on DT by providing insights into the faddishness and semblance of leading consulting firms’ discourse on DT, while also shedding light on the nuances of DT consulting and its potential for improvement.
Quantile Fourier regressions for decision making under uncertainty
Authors: Khojaste Arash , Pritchard Geoffrey , Zakeri Golbon 
Published: October 2024

AbstractWe consider Markov decision processes arising from a Markov model of an underlying natural phenomenon. Such phenomena are usually periodic (e.g. annual) in time, and so the Markov processes modelling them must be time-inhomogeneous, with cyclostationary rather than stationary behaviour. We describe a technique for constructing such processes that allows for periodic variations both in the values taken by the process and in the serial dependence structure. We include two illustrative numerical examples: a hydropower scheduling problem and a model of offshore wind power integration.
Microplastic contamination in three environmental compartments of a coastal lagoon in the southern Gulf of Mexico
Authors: Sánchez-Campos Mitzi , Ponce-Vélez Guadalupe , Sanvicente-Añorve Laura , Alatorre-Mendieta Miguel 
Published: October 2024

AbstractThe Sontecomapan lagoon (Mexico) is a Ramsar site within the Los Tuxtlas Biosphere Reserve, facing the Gulf of Mexico. Although the site has a protected area status, it is vulnerable to microplastic contamination, whose long-term effects are uncertain. This study gives the first approach to the degree of contamination by microplastics in surface waters, zooplankton, and sediments in the lagoon. The samples in these three environmental compartments were collected in June 2018 and analyzed in the laboratory to extract and quantify the microplastics. The microplastics sampled were classified into fibers, fragments, and foams and identified as polyester, acrylic, and rayon, among others. In the surface waters, the mean concentration of microplastics was 7.5 ± 5.3 items/L, which is higher than the values registered in other protected coastal systems, perhaps because of differences in the methods used. Zooplankton, represented by copepods, luciferids, and chaetognaths, showed concentrations of 0.002 ± 0.005, 0.011 ± 0.011, and 0.019 ± 0.016 items/individual, respectively. These values were low compared to systems with high anthropic influence, and the differences between the three kinds of organisms were attributed to their feeding habits. In the sediments, the mean concentration was 8.5 ± 12.5 items/kg, lower than the values registered in sites of high human impact; the maximum value here found (43 items/kg) was recorded in the internal part of a lagoon arm of almost stagnant water. In general, the degree of contamination by microplastics in the lagoon was low; however, their presence indicates a potential risk to the biota.
Large language models and their big bullshit potential
Authors: Fisher Sarah A. 
Published: October 2024

AbstractNewly powerful large language models have burst onto the scene, with applications across a wide range of functions. We can now expect to encounter their outputs at rapidly increasing volumes and frequencies. Some commentators claim that large language models are bullshitting, generating convincing output without regard for the truth. If correct, that would make large language models distinctively dangerous discourse participants. Bullshitters not only undermine the norm of truthfulness (by saying false things) but the normative status of truth itself (by treating it as entirely irrelevant). So, do large language models really bullshit? I argue that they can, in the sense of issuing propositional content in response to fact-seeking prompts, without having first assessed that content for truth or falsity. However, I further argue that they need not bullshit, given appropriate guardrails. So, just as with human speakers, the propensity for a large language model to bullshit depends on its own particular make-up.
Spatiotemporal multilevel joint modeling of longitudinal and survival outcomes in end-stage kidney disease
Authors: Kürüm Esra , Nguyen Danh V. , Qian Qi , Banerjee Sudipto , Rhee Connie M. , Şentürk Damla 
Published: October 2024

AbstractIndividuals with end-stage kidney disease (ESKD) on dialysis experience high mortality and excessive burden of hospitalizations over time relative to comparable Medicare patient cohorts without kidney failure. A key interest in this population is to understand the time-dynamic effects of multilevel risk factors that contribute to the correlated outcomes of longitudinal hospitalization and mortality. For this we utilize multilevel data from the United States Renal Data System (USRDS), a national database that includes nearly all patients with ESKD, where repeated measurements/hospitalizations over time are nested in patients and patients are nested within (health service) regions across the contiguous U.S. We develop a novel spatiotemporal multilevel joint model (STM-JM) that accounts for the aforementioned hierarchical structure of the data while considering the spatiotemporal variations in both outcomes across regions. The proposed STM-JM includes time-varying effects of multilevel (patient- and region-level) risk factors on hospitalization trajectories and mortality and incorporates spatial correlations across the spatial regions via a multivariate conditional autoregressive correlation structure. Efficient estimation and inference are performed via a Bayesian framework, where multilevel varying coefficient functions are targeted via thin-plate splines. The finite sample performance of the proposed method is assessed through simulation studies. An application of the proposed method to the USRDS data highlights significant time-varying effects of patient- and region-level risk factors on hospitalization and mortality and identifies specific time periods on dialysis and spatial locations across the U.S. with elevated hospitalization and mortality risks.