bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol-decreased hyperalgesia mediated by the P2X7 receptor in gp120-treated rats
Authors: Wu Bing , Ma Yucheng , Yi Zhihua , Liu Shuangmei , Rao Shenqiang , Zou Lifang , Wang Shouyu , Xue Yun , Jia Tianyu , Zhao Shanhong , Shi Liran , Li Lin , Yuan Huilong , Liang Shangdong 
Published: May 2017

Background Chronic pain is a common symptom in human immunodeficiency virus (HIV)-1 infection/acquired immunodeficiency syndrome patients. The literature shows that the HIV envelope glycoprotein 120 (gp120) can directly cause hyperalgesia by stimulating primary sensory afferent nerves. The P2X7 receptor in the dorsal root ganglia (DRG) is closely related to neuropathic and inflammatory pain. In this study, we aimed to explore the effect of resveratrol (RES) on gp120-induced neuropathic pain that is mediated by the P2X7 receptor in the rat DRG. Results Mechanical hyperalgesia in rats treated with gp120 was increased compared with that in the sham group. The P2X7 expression levels in rats treated with gp120 were higher than those in the sham group. Co-localization of the P2X7 receptor and glial fibrillary acidic protein (GFAP, a marker of satellite glial cells [SGCs]) in the DRG SGCs of the gp120 group exhibited more intense staining than that of the sham group. RES decreased the mechanical hyperalgesia and P2X7 expression levels in gp120 treatment rats. Co-localization of the P2X7 receptor and GFAP in the gp120+ RES group was significantly decreased compared to the gp120 group. RES decreased the IL-1β and TNF-α receptor (R) expression levels and ERK1/2 phosphorylation levels as well as increased IL-10 expression in the DRG of gp120-treated rats. Whole cell clamping demonstrated that RES significantly inhibited adenosine triphosphate-activated currents in HEK293 cells that were transfected with the P2X7 plasmid. Conclusions RES relieved mechanical hyperalgesia in gp120-treated rats by inhibiting the P2X7 receptor.
Suppression of asparaginyl endopeptidase attenuates breast cancer-induced bone pain through inhibition of neurotrophin receptors
Authors: Yao Peng , Ding Yuanyuan , Han Zhenkai , Mu Ying , Hong Tao , Zhu Yongqiang , Li Hongxi 
Published: May 2017

Objective Cancer-induced bone pain is a common clinical problem in breast cancer patients with bone metastasis. However, the mechanisms driving cancer-induced bone pain are poorly known. Recent studies show that a novel protease, asparaginyl endopeptidase (AEP) plays crucial roles in breast cancer metastasis and progression. We aim to determine the functions and targeted suppress of AEP in a mouse model of breast cancer-induced bone pain. Methods Breast cancer cells with AEP knocked-down or overexpression were constructed and implanted into the intramedullary space of the femur to induce pain-like behavior in mice. AEP-specific inhibitors or purified AEP proteins were further used in animal model. The histological characters of femur and pain ethological changes were measured. The expressions of AEP and neurotrophin receptors (p75NTR and TrkA) in dorsal root ganglion and spinal cord were examined. Results Femur radiographs and histological analysis revealed that cells with AEP knocked-down reduced bone destruction and pain behaviors. However, cells with AEP overexpression elevated bone damage and pain behaviors. Further, Western blot results found that the expressions of p75NTR and TrkA in dorsal root ganglions and spinal cords were reduced in mice inoculated with AEP knocked-down cells. Targeted suppression of AEP with specific small compounds significantly reduced the bone pain while purified recombinant AEP proteins increased bone pain. Conclusions AEP aggravate the development of breast cancer bone metastasis and bone pain by increasing the expression of neurotrophin receptors. AEP might be an effective target for treatment of breast cancerinduced bone pain.
T1-weighted dynamic contrast-enhanced brain magnetic resonance imaging: A preliminary study with low infusion rate in pediatric patients
Authors: Rochetams Bruno-Bernard , Marechal Bénédicte , Cottier Jean-Philippe , Gaillot Kathleen , Sembely-Taveau Catherine , Sirinelli Dominique , Morel Baptiste 
Published: May 2017

Background The aim of this preliminary study is to evaluate the results of T1-weighted dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in pediatric patients at 1.5T, with a low peripheral intravenous gadoteric acid injection rate of 1 ml/s. Materials and methods Children with neurological symptoms were examined prospectively with conventional MRI and T1-weighted DCE MRI. An magnetic resonance perfusion analysis method was used to obtain time–concentration curves (persistent pattern, type-I; plateau pattern, type-II; washout pattern, type-III) and to calculate pharmacokinetic parameters. A total of two radiologists manually defined regions of interest (ROIs) in the part of the lesion exhibiting the greatest contrast enhancement and in the surrounding normal or contralateral tissue. Lesion/surrounding tissue or contralateral tissue pharmacokinetic parameter ratios were calculated. Tumors were categorized by grade (I–IV) using the World Health Organization (WHO) Grade. Mann–Whitney testing and receiver-operating characteristic (ROC) curves were performed. Results A total of nine boys and nine girls (mean age 10.5 years) were included. Lesions consisted of 10 brain tumors, 3 inflammatory lesions, 3 arteriovenous malformations and 2 strokes. We obtained analyzable concentration–time curves for all patients (6 type-I, 9 type-II, 3 type-III). Ktrans between tumor tissue and surrounding or contralateral tissue was significantly different ( p = 0.034). Ktrans ratios were significantly different between grade I tumors and grade IV tumors ( p = 0.027) and a Ktrans ratio value superior to 0.63 appeared to be discriminant to determine a grade IV of malignancy. Conclusions Our results confirm the feasibility of pediatric T1-weighted DCE MRI at 1.5T with a low injection rate, which could be of great value in differentiating brain tumor grades.
ЭПИДЕМИЧЕСКАЯ СИТУАЦИЯ ПО ТУБЕРКУЛЕЗУ В ЧЕЧЕНСКОЙ РЕСПУБЛИКЕ В СОВРЕМЕННЫХ СОЦИАЛЬНО-ЭКОНОМИЧЕСКИХ УСЛОВИЯХ
Authors: Alekseeva Vera Mikhailovna , Batukaeva Zaira Makanovna , Saidullaev Arbi-Khazhi Abuezidovich , Kozlov Vasily Vladimirovich , Mikerova Maria Sergeevna 
Published: May 2017

Введение. Туберкулез является одной из наиболее значимых медико-социальных проблем как во всем мире, так и на территории России и отдельных ее регионов.Цель. Целью работы явилась оценка эпидемической ситуации по туберкулезу в Чеченской Республике в сложившихся современных социально-экономических условиях после проведенных контртеррористических операций (1994–1996 гг., 1999–2004 гг.).Методы. Источником информации послужили годовые отчеты Министерства здравоохранения Чеченской Республики за 2010–2015 гг., данные Росстата, статистические формы по туберкулезу (№ 8 и № 30).Результаты. Установлено трехкратное увеличение основных показателей по туберкулезу – заболеваемости, распространенности и смертности после контртеррористических операций (1994–1996 гг.) и снижение этих показателей в период 2010–2015 гг. Определены города и сельские муниципальные районы с наиболее и наименее благоприятной ситуацией по туберкулезу. Установлено увеличение в последние годы числа больных с бациллярной, с фиброзно-кавернозной формой, а также больных туберкулезом в сочетании с ВИЧ-инфекцией. Доказано, что со снижением распространенности фиброзно-кавернозной формы туберкулеза снижается показатель смертности от туберкулеза. Установлено снижение показателя заболеваемости туберкулезом в динамике за 2010–2015 гг. детей (0–14 лет) и подростков (15–17 лет), при этом заболеваемость подростков остается выше заболеваемости детей.Заключение. Для эффективной борьбы с туберкулезом на территории Чеченской Республики требуется совершенствование проведения медицинских осмотров, раннего выявления заболевших, своевременное проведение мер по иммунопрофилактике, усиление санитарно-просветительской работы.
Redesigning the Concept of Money: A Service Design Perspective on Complementary Currency Systems
Authors: Telalbasic Ida 
Published: May 2017

Abstract
The current failures in income distribution among communities, social entrepreneurs and start-up founders result from deficit of money for accessing goods and services. However, it is increasingly recognized that money has the potential to be redesigned in order to serve a different purpose and to adapt to the emerging paradigm of the collaborative economy. Within this context, this article presents a study aimed to explore complementary currency systems as resilient strategies. This is done by adopting a service design perspective to analyse case studies from developing and developed economies. Both contexts are investigated in order to identify whether the case studies are founded by individuals, communities or governments. Furthermore, organizational models, as well as the main motivations and conditions for the emergence of these alternative economic models, are examined. Moreover, the key drivers for creating complementary currency systems are highlighted. For instance, in the developing world, those systems stem from the need for establishing financial inclusion and building stronger trust and community ties. Instead, in developed economies, they rise in order to use existing local resources, foster individual empowerment, enhance collaboration with a community, as well as achieve economic benefit. Complementary currency systems are here proposed as a tool for linking unmet needs with unused resources. They also enable informal financial institutions contributing to behavioural change through meritocracy. Once those systems are designed as small-scale initiatives, prototyped and implemented in different communities, they have the potential to become effective strategies for subversion and intervention. The case studies show that equal participation and local empowerment can lead to proactive democratic models increasing economic stability. In conclusion, this article argues that service design, through systems of permanent or temporary access to credit, not only responds to contemporary socio-economic conditions, but also contributes to shape new ways of practicing democratized economics.
Design-Intensive Start-Ups: A New Application Field for Design Thinking?
Authors: Cautela Cabirio , Rampino Lucia , Colombo Sara , Simonelli Giuliano 
Published: May 2017

Abstract
This article analyses a new phenomenon that has until now been poorly researched both in entrepreneurial and design-related literature, namely start-ups that focus on design as the primary source for their development (i.e. design-intensive start-ups, or DIS).
Two main questions underpin the study, which is explorative in nature. Firstly, how do DIS differ from new technology start-ups (NTS) in terms of critical dimensions for development? Secondly, do DIS use design in a specific way?
A multiple case study protocol was adopted to investigate these two questions. Results show that DIS not only differ from NTS with respect to several core dimensions, but they also differ in terms of overall new venture creation logic. The theoretical and practical implications of these findings for design thinking studies are discussed.
Sacred Service: The Use of ‘Sacred Theory’ in Service Design
Authors: Matthews Ted 
Published: May 2017

Abstract
Whilst attention has been given to the sacred in consumer behaviour, often highlighting its potential for meaningful experiences and customer loyalty, little research has been undertaken which investigates how such experiences might be designed for.
This article describes a new service design approach that marries material from sacred theory and the tools of service design with the aim of designing for sacred service experiences.
The method was developed through a research by design approach during three service design projects.
Although not fully implemented and limited to a Norwegian context, the solutions show innovation in process and outcome, particularly when it comes to designing for meaningful experiences, incorporating central elements of the sacred experience. It can be concluded that the method operationalizes the sacred and was considered a useful and usable addition to existing service design approaches.
The method is one of the first approaches that specifically incorporate cultural material into the service design process, raising the importance of meaning and values alongside that of the functional. It shows that service designers can act as cultural intermediaries and that service design lacks a cultural orientation in its existing practice. Based upon this, the article encourages the rethinking of several service design terms and suggests how the approach that has been developed could form part of a ‘semantic turn’ in service design.
The article contributes to the research and practice in service design by introducing an approach for the design for sacred experiences and for incorporating cultural influences into service design. Further, it introduces cultural theory in the form of sacred theory as material for service design and establishes a discourse regarding the service designer as cultural intermediary. It introduces a discussion about exploring culture as a design material in service design.
‘Pas d’hospitalité’: Derrida and the study of hospitality in higher education
Authors: Hemmington Nigel , Gibbons Andrew 
Published: May 2017

Abstract
This article explores Jacques Derrida’s deconstruction of hospitality within the context of the study of hospitality in higher education. The contribution of Derrida’s work is discussed, and then Derrida’s thoughts on the possibility of hospitality are explored in relation to hospitality education. The implications of absolute (unconditional) hospitality, reciprocity, generosity, transactions and the Internet are then explored within the context of Derrida’s thinking, particularly his possible–impossible aporia. This conceptual approach is presented in an anticipation that these ideas will create astonishment that will stimulate new and different approaches to thinking about hospitality, and will in turn have implications for hospitality education and the hospitality industry.
Missing voices: Australian children’s insights and perceptions of family holidays
Authors: Hay Brian 
Published: May 2017

Abstract
Through 26 face-to-face parental supervised discussions with children (9–14 years of age) at various 4/5 star hotels in Australia from 2009–14, four themes were explored: food and family dining; privacy and personal space; fun and enjoyment; socialization. The results suggest that children expect the same quality of services/facilities in hotels as they have at home, and while they recognized that some services/facilities are designed for and are more suitable for adults, they nevertheless expect equal access to services/facilities. In addition, the children also recognized that family holidays provided an opportunity to connect through shared social experiences, with their siblings and parents, but also with children from outside the family group. The key insights were: first, we may have underestimated the importance of family holidays in providing a safe space for children to raise challenging family issues not normally discussed at home. Second, we may have undervalued the role that hotel staff and children from outside the family can play in strengthening the socialization aspects of the family holiday. Third, we may have failed to recognize there are not two separate worlds in the provision of hotel services: a children’s world and an adult world. As children grow older they expect fluidity in the provision of hotel services, as they increasingly move between their child world and the adult world.
Hospitality: Ideologies, characteristics and conditionality in Theravada Buddhism and Western philosophy
Authors: Munasinghe Sarath , Hemmington Nigel , Schänzel Heike , Poulston Jill , Fernando Thakshala 
Published: May 2017

Abstract
Hospitality is central to the social fabric of many societies, however, the term has contested meanings and is discussed and interpreted differently in different discourses. After exploring the concept of hospitality, this review analyses the meanings and ideologies of hospitality in Theravada Buddhism and Western philosophy. It acknowledges the dominant view of hospitality that is largely grounded in Western philosophical traditions, where key concepts include understandings of hospitality in relation to God, conditional and unconditional hospitality, and universal hospitality. However, in Buddhism, hospitality is seen as a part of da-na – ‘generous giving’ – the first step in breaking attachment to desire, and a fundamental virtue of the spiritual life. This review of conceptualizations of hospitality in Western and Eastern contexts surrenders both similarities and differences, and although the concepts of host, guest and hospitality are similar, Theravada Buddhism provides new insights into the nature of reciprocity and conditionality, with consequent implications for Western understandings of hospitality.
Too close to servility? Why is hospitality in New Zealand still a ‘Cinderella’ industry?
Authors: Williamson David 
Published: May 2017

Abstract
Something strange is going on in New Zealand’s hospitality industry. While the sector is booming (with tourism bringing in 34.7 billion dollars in 2016 and driving record growth in hospitality jobs and hotel building), New Zealanders seem to remain unconvinced about the legitimacy of hospitality as industry and as a career choice. At a time when there are thousands of new jobs being created in hospitality, why does it remain a ‘dummy subject’ in schools? Why do so many parents ‘get the hint’ and hope their kids do anything other than hospitality work? In the 1950s the New Zealand tourism sector was known as the ‘Cinderella of industries’, underfunded, of ‘doubtful value’ and home to poor quality jobs. This paper argues that the New Zealand hospitality is the modern Cinderella industry and is burdened by three historical legacies, which are affecting our ability to maximize the current opportunities in hospitality, and threaten a sustainable future for the sector: distrust, disdain and the legacy of neo-liberal reform.
Book Review
Authors: Lane Eifiona Thomas 
Published: May 2017

Abstract
Gastronomy, Tourism and the Media, Warwick Frost, Jennifer Laing, Gary Best, Kim Williams, Paula Strickland and Clare Lade (2016) Bristol and Tonawanda, NY: Channel View Publications, Aspects of Tourism, ix + 242 pp., ISBN: 9781845415730, p/bk, £29.95
Open Space: Book Reviews
Authors: Davis Joy , Square Jonathan Michael , Tulloch Carol 
Published: May 2017

Abstract
Fashion and Jazz: Dress, Identity and Subcultural Improvisation, Alphonso McClendon (2015) First Edition, London and New York: Bloomsbury, 216 pp. ISBN: 9780857851291, Paperback, $27.99
The Birth of Cool: Style Narratives of the African Diaspora, Carol Tulloch (2016) First Edition, London and New York: Bloomsbury, 272 pp. ISBN: 9781474262873, Paperback, $24.99
Liberated Threads: Black Women, Style and the Global Politics of Soul, Tanisha C. Ford (2015) First Edition, Durham: University of North Carolina Press, 272 pp. ISBN: 9781469625157, Hardback, $29.95
The revolution in our pants: Hipsters, race and American fashion
Authors: Gilson Duane 
Published: May 2017

Abstract
This article explores the contemporary jogger pant by looking back to the mid-twentieth-century coding of hipness through material consumption, racial mastery and urbanity, primarily through Malcolm X’s musing on zoot suits, but also attending to adjacent literary texts: Gwendolyn Brooks’ poem ‘We Real Cool’ and Norman Mailer’s essay ‘The white negro: Superficial reflections on the hipster’. It finally returns to the present day to read the contemporary jogger alongside the midcentury zoot suit, gesturing to ways in which hipster appropriation is both problematic, because it assumes as authentic cultural products of whiteness that actually borrow from blackness, and full of potential, because in even quietly citing its borrowing of black and feminine forms, it may serve to destabilize white masculinity.
Young people’s experiences of fashion modelling: An exploratory phenomenological study
Authors: Carr Daniel J. , Mercer Jenny 
Published: May 2017

Abstract
Research into fashion modelling within the field of psychology remains sparse. Empirical studies do exist, but they are rare and exhibit a tendency to pathologize models, and provide only a superficial insight into this career. Little is known about who a fashion model really is; what a young person who models experiences in their careers; or how fashion models make sense of their role. With this in mind, the current study seeks to explore the lived experience of young people who are fashion models. Three participants offered experiential accounts of modelling in the fashion industry, and Interpretative Phenomenological Analysis (IPA) revealed superordinate themes: ‘Growth and Development’, ‘Changes in Self-Perception’ and ‘A Job? Or a Way of Life?’ Change was found to be an integral part of the participants’ experiences, which led to both positive and negative developmental outcomes, including a self-reported growth in confidence and maturity, yet a potentially more self-critical view of one’s appearance. The role seemed to be an all-encompassing lifestyle rather than a job, and it is argued that modelling at a young age may act as a catalyst for a transition into adulthood. This study is exploratory in nature but provides an initial insight into the experiences of fashion modelling. The discussion identifies ways in which cognate sub-disciplines of psychology may contribute to this area of research, thus developing and extending further the psychological literature base in the field of fashion studies.
Fashion watches: The emergence of accessory makers as intermediaries in the fashion system
Authors: Donzé Pierre-Yves 
Published: May 2017

Abstract
The objective of this article is to analyse the historical conditions of the emergence of accessory makers as intermediaries in the fashion system, with the example of the watch company Fossil Inc. More specifically, it sheds light on the twofold evolution of watchmaking (towards global value chains centred on Hong Kong) and of the fashion industries (towards the need to enlarge profits through accessorization), which has led to an increase of newcomers to these industries. This article approaches its investigation from the perspective of business history. The analysis of Fossil since 1984 is based on corporate annual reports and offers a survey of the organizational evolution of the watch and fashion industries, in order to shed light on the strategy and decision-making of this company. In the context of the discussion about the role of intermediaries in creating and legitimizing fashion, this contribution offers new evidence about understudied actors in the industry, i.e. accessory makers. It shows that firms like Fossil are not only passive suppliers of branded accessories, but also contribute to the growth of accessory sales – and consequently, to the strengthening of fashion brands.
Book Reviews
Authors: Green Denise , Jobling Paul 
Published: May 2017

Abstract
Fashion Victims: The Dangers of Dress Past and Present, Alison Matthews David (2015) First Edition, London and New York: Bloomsbury, 256 pp. ISBN: 9781845204495, Hardback, $27.99
Street Style: An Ethnography of Fashion Blogging, Brent Luvaas (2016) First Edition, London and New York: Bloomsbury, 320 pp. 147 colour and b/w figures, ISBN: 9780857855756, Paperback, $29.95