bluuebunny/crossref_metadata_2025_split huggingface dataset:
UPLC-PDA factorial design assisted method for simultaneous determination of oseltamivir, dexamethasone, and remdesivir in human plasma
Authors: EL-Shorbagy Hanan I. , Mohamed Mona A. , El-Gindy Alaa , Hadad Ghada M. , Belal Fathalla 
Published: September 2024

AbstractA green and simple UPLC method was developed and optimized, adopting a factorial design for simultaneous determination of oseltamivir phosphate and remdesivir with dexamethasone as a co-administered drug in human plasma and using daclatasvir dihydrochloride as an internal standard within 5 min. The separation was established on UPLC column BEH C18 1.7 μm (2.1 $$\times $$
×
100.0 mm) connected to UPLC pre-column BEH 1.7 μm (2.1 $$\times $$
×
5.0 mm) at 50 °C with an injection volume of 10 μL. The photodiode array detector (PDA) was set at three wavelengths of 220, 315, and 245 nm for oseltamivir phosphate, the internal standard, and both dexamethasone and remdesivir, respectively. The mobile phase consisted of methanol and ammonium acetate solution (40 mM) adjusted to pH 4 in a ratio of 61.5:38.5 (v/v) with a flow rate of 0.25 mL min−1. The calibration curves were linear over 500.0–5000.0 ng mL−1 for oseltamivir phosphate, over 10.0–500.0 ng mL−1 and 500.0–5000.0 ng mL−1 for dexamethasone, and over 20.0–500 ng mL−1 and 500.0–5000.0 ng mL−1 for remdesivir. The Gibbs free energy and Van't Hoff plots were used to investigate the effect of column oven temperatures on retention times. Fluoride-EDTA anticoagulant showed inhibition activity on the esterase enzyme in plasma. The proposed method was validated according to the M10 ICH, FDA, and EMA’s bioanalytical guidelines. According to Eco-score, GAPI, and AGREE criteria, the proposed method was considered acceptable green.
Green synthesis of silver and gold-doped zinc oxide nanocomposite with propolis extract for enhanced anticancer activity
Authors: Abdelsattar Abdallah S. , Yakoup Aghapy Yermans , Kamel Azza G. , El-Shibiny Ayman 
Published: September 2024

AbstractMetal and metal oxide nanocomposites have unique properties and are promising for antibacterial and anticancer applications. In this work, we aimed to highlight the relationship between the biosynthesis ways of silver and gold-doped zinc oxide nanocomposites and their functions as anticancer on cell lines (MCF-7 and HepG2). The propolis was used to biosynthesize four different nanoparticles with the same components, including zinc, gold and silver. The nanocomposites were characterized using various techniques, including ultraviolet–visible spectroscopy (UV–Vis), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Energy Dispersive X-ray analysis (EDX) and cytotoxicity assays. The result of this study showed that formed nanocomposites have a similar level of Zn, Au, and Ag, ranging from 23–34%, 2–6%, and 2–3%, respectively. In addition, adding the components simultaneously produces the fastest color change, and the fabricated nanoparticles have spherical shapes with different layers. In addition, the prepared nanoparticles influenced the cell viability of the cancer cell lines, with the most effective one when Zn, Au, and Ag were added spontaneously to form a nanocomposite called (All) with IC50 of 24.5 µg/mL for MCF7 cells and 29.1 µg/mL for HepG2 cells. Thus, the study illustrates that the preparation of nanocomposite generated through green synthesis with different methods significantly affects the structure and function and may improve the synthesis of nanocomposite to be developed into an efficacious therapeutic agent for cancers. In addition, this study opens the door toward a novel track in the field of nanocomposites as it links the synthesis with structure and function. Further anti-cancer properties, as well as animal testing are needed for those nanocomposites.
National Park visitors perceive benefits for themselves and wildlife under blended red-white outdoor lighting
Authors: Fristrup Kurt , Miller Zachary D. , Newton Jennifer , Buckley Stephanie , Cole Hunter , Linares Carlos , Donners Maurice , Taff B. Derrick , Beeco J. Adam , Barber Jesse , Newman Peter 
Published: September 2024

AbstractVisitors to Colter Bay Village in Grand Teton National Park were surveyed to elicit their evaluations of experimental outdoor lighting conditions. Luminaires capable of dimming and switching between two LED modules (white, blended red-white) were installed in street and parking areas. The blended red-white lamps consisted of 30 narrowband LED with a peak wavelength 623 nm and two 3000 K white LEDs. Similar “red” lamps were previously shown to reduce impacts to bats and insects. The white and red lamps were closely matched for luminance. Measured horizontal illuminance at survey locations had an interquartile range from 0.63 to 3.82 lx. The red lamps produced lower perceived brightness (VB2(λ)), even after reflection off asphalt, yet survey participants expressed higher ratings for visual comfort and safety under red lighting. Surveys conducted earlier in the evening, with higher levels of predicted solar and measured horizontal illuminance, rated higher on visual comfort and safety, though these correlations were not as strong as the effect of lamp color. Streetlight ratings and support for lighting that protected natural resources were not contingent upon age or gender. Survey participants assessed red lighting as more protective of the environment. These results demonstrate that outdoor lighting designed to reduce ecological impacts can yield superior nocturnal experience for pedestrians.
Hybrid quantum-classical computation for automatic guided vehicles scheduling
Authors: Śmierzchalski Tomasz , Pawłowski Jakub , Przybysz Artur , Pawela Łukasz , Puchała Zbigniew , Koniorczyk Mátyás , Gardas Bartłomiej , Deffner Sebastian , Domino Krzysztof 
Published: September 2024

AbstractMotivated by recent efforts to develop quantum computing for practical, industrial-scale challenges, we demonstrate the effectiveness of state-of-the-art hybrid (not necessarily quantum) solvers in addressing the business-centric optimization problem of scheduling Automatic Guided Vehicles (AGVs). Some solvers can already leverage noisy intermediate-scale quantum (NISQ) devices. In our study, we utilize D-Wave hybrid solvers that implement classical heuristics with potential assistance from a quantum processing unit. This hybrid methodology performs comparably to existing classical solvers. However, due to the proprietary nature of the software, the precise contribution of quantum computation remains unclear. Our analysis focuses on a practical, business-oriented scenario: scheduling AGVs within a factory constrained by limited space, simulating a realistic production setting. Our approach maps a realistic AGVs problem onto one reminiscent of railway scheduling and demonstrates that the AGVs problem is better suited to quantum computing than its railway counterpart, the latter being denser in terms of the average number of constraints per variable. The main idea here is to highlight the potential usefulness of a hybrid approach for handling AGVs scheduling problems of practical sizes. We show that a scenario involving up to 21 AGVs, significant due to possible deadlocks, can be efficiently addressed by a hybrid solver in seconds.
Machine learning misclassification networks reveal a citation advantage of interdisciplinary publications only in high-impact journals
Authors: Lyutov Alexey , Uygun Yilmaz , Hütt Marc-Thorsten 
Published: September 2024

AbstractGiven a large enough volume of data and precise, meaningful categories, training a statistical model to solve a classification problem is straightforward and has become a standard application of machine learning (ML). If the categories are not precise, but rather fuzzy, as in the case of scientific disciplines, the systematic failures of ML classification can be informative about properties of the underlying categories. Here we classify a large volume of academic publications using only the abstract as information. From the publications that are classified differently by journal categories and ML categories (i.e., misclassified publications, when using the journal assignment as ground truth) we construct a network among disciplines. Analysis of these misclassifications provides insight in two topics at the core of the science of science: (1) Mapping out the interplay of disciplines. We show that this misclassification network is informative about the interplay of academic disciplines and it is similar to, but distinct from, a citation-based map of science, where nodes are scientific disciplines and an edge indicates a strong co-citation count between publications in these disciplines. (2) Analyzing the success of interdisciplinarity. By evaluating the citation patterns of publications, we show that misclassification can be linked to interdisciplinarity and, furthermore, that misclassified articles have different citation frequencies than correctly classified articles: In the highest 10 percent of journals in each discipline, these misclassified articles are on average cited more frequently, while in the rest of the journals they are cited less frequently.
Fisheries shocks provide an opportunity to reveal multiple recruitment sources of sardine in the Sea of Japan
Authors: Sakamoto Tatsuya , Takahashi Motomitsu , Shirai Kotaro , Aono Tomoya , Ishimura Toyoho 
Published: September 2024

AbstractThe abrupt decline in sardine catches in the Sea of Japan and the East China Sea (SJ-ECS) in 2014 and 2019 and the recovery in the following years call into question the current assumption that sardines in the SJ-ECS form a self-recruiting subpopulation. To test this hypothesis, we analysed otolith stable oxygen and carbon isotope profiles (δ18O, δ13C) of age-0 and age-1 sardines from 2010 and 2013–2015 year-classes captured in the SJ-ECS, as geographic markers for nursery areas. Age-0 sardines generally showed a significant ontogenetic decrease in otolith δ18O from larval to juvenile stages. However, the majority of age-1 captured in spring 2011, 2015 and 2016 showed non-decreasing otolith δ18O profiles, suggesting that the age-0 off the Japanese coast were not the main source of recruitment. Different migration groups were thus indicated: the “locals” growing up off the Japanese coast and the migrating “nonlocals”. The isotope profiles of the “nonlocals” overlapped with those of age-0 captured in the subarctic North Pacific, suggesting that they may be migrants from the Pacific, or perhaps an unobserved northward migration group in the SJ-ECS. Our results highlight the considerable uncertainty in the population structure assumed in current stock assessment models for Japanese sardine.
Effect of silver nanoparticles foliar application on the nutritional properties of potato tubers
Authors: Tokarz Krzysztof M. , Mazur Tomasz , Hanula Monika , Makowski Wojciech , Zawal Piotr , Jędrzejczyk Roman J. , Szacilowski Konrad , Mazur Stanisław , Wesołowski Wojciech , Tokarz Barbara 
Published: September 2024

AbstractThe aim of presented study was to test nutritional properties of potato tubers and silver ions accumulation pattern after foliar application of silver nanoparticles (AgNPs) during potato vegetation. Potato plants were sprayed with different concentration of Ag nanoparticles (0.1, 1.0 and 10 mg·dm−3) synthesized with incorporation with sodium dodecyl sulphate (SDS) and sodium citrate as stabilizing agent. The lowest amounts of silver ions were transported to the tubers after spraying with AgNPs synthesized with SDS, rather than with citrate. Nevertheless silver ions accumulation in tubers was negligible. SDS method of synthesis was more favourable in terms of nutritional properties of potato tubers. The highest tested concentration of AgNPs_SDS had a favourable effect on a variety of macro- and micronutrients, ascorbic acid and soluble sugars. In turn, lower concentrations of AgNPs_SDS increased the content of phenolic compounds and free radical scavenging efficiency of tubers. These correlations were also confirmed by Principal Component Analysis.
Emergence of group size disparity in growing networks with adoption
Authors: Sun Jun , Karimi Fariba 
Published: September 2024

AbstractSocial and technical networks undergo constant evolution driven by both existing entities and newcomers. In academia, research papers are continually cited by new papers, while senior researchers integrate newly arrived junior researchers into their academic networks. Moreover, social systems can be influenced by external factors that could indirectly impact their growth patterns. For instance, systematic discrimination against certain groups in academia or managerial positions can impede their long-term growth, especially when combined with group-level preferences in hiring or adoption, as observed in our study. To address this, we introduce a network growth and adoption model where generalised preferential attachment and asymmetric mixing act as the two fundamental mechanisms of growth and adoption. We show analytically and numerically that these mechanisms can recover the empirical properties of citation and collaboration growth, as well as the inequalities observed in the growth dynamics of groups. This model can be used to investigate the effect of intervention in group mixing preferences to overcome the cumulative disparities in the group-level dynamics.
A population-based study of familial coaggregation and shared genetic etiology of psychiatric and gastrointestinal disorders
Authors: Pan Yi-Jiun , Lin Mei-Chen , Liou Jyh-Ming , Fan Chun-Chieh , Su Mei-Hsin , Chen Cheng-Yun , Wu Chi-Shin , Chen Pei-Chun , Huang Yen-Tsung , Wang Shi-Heng 
Published: September 2024

Abstract
Background
It has been proposed that having a psychiatric disorder could increase the risk of developing a gastrointestinal disorder, and vice versa. The role of familial coaggregation and shared genetic loading between psychiatric and gastrointestinal disorders remains unclear.

Methods
This study used the Taiwan National Health Insurance Research Database; 4,504,612 individuals born 1970–1999 with parental information, 51,664 same-sex twins, and 3,322,959 persons with full-sibling(s) were enrolled. Genotyping was available for 106,796 unrelated participants from the Taiwan Biobank. A logistic regression model was used to examine the associations of individual history, affected relatives, and polygenic risk scores (PRS) for schizophrenia (SCZ), bipolar disorder (BPD), major depressive disorder (MDD), and obsessive-compulsive disorder (OCD), with the risk of peptic ulcer disease (PUD), gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD), and vice versa.

Results
Here we show that parental psychiatric disorders are associated with gastrointestinal disorders. Full-siblings of psychiatric cases have an increased risk of gastrointestinal disorders except for SCZ/BPD and IBD; the magnitude of coaggregation is higher in same-sex twins than in full-siblings. The results of bidirectional analyses mostly remain unchanged. PRS for SCZ, MDD, and OCD are associated with IBS, PUD/GERD/IBS/IBD, and PUD/GERD/IBS, respectively. PRS for PUD, GERD, IBS, and IBD are associated with MDD, BPD/MDD, SCZ/BPD/MDD, and BPD, respectively.

Conclusions
There is familial coaggregation and shared genetic etiology between psychiatric and gastrointestinal comorbidity. Individuals with psychiatric disorder-affected relatives or with higher genetic risk for psychiatric disorders should be monitored for gastrointestinal disorders, and vice versa.
Acetylation of TIR domains in the TLR4-Mal-MyD88 complex regulates immune responses in sepsis
Authors: Li Xue , Li Xiangrong , Huang Pengpeng , Zhang Facai , Du Juanjuan K , Kong Ying , Shao Ziqiang , Wu Xinxing , Fan Weijiao , Tao Houquan , Zhou Chuanzan , Shao Yan , Jin Yanling , Ye Meihua , Chen Yan , Deng Jong , Shao Jimin , Yue Jicheng , Cheng Xiaju , Chinn Y Eugene 
Published: September 2024

AbstractActivation of the Toll-like receptor 4 (TLR4) by bacterial endotoxins in macrophages plays a crucial role in the pathogenesis of sepsis. However, the mechanism underlying TLR4 activation in macrophages is still not fully understood. Here, we reveal that upon lipopolysaccharide (LPS) stimulation, lysine acetyltransferase CBP is recruited to the TLR4 signalosome complex leading to increased acetylation of the TIR domains of the TLR4 signalosome. Acetylation of the TLR4 signalosome TIR domains significantly enhances signaling activation via NF-κB rather than IRF3 pathways. Induction of NF-κB signaling is responsible for gene expression changes leading to M1 macrophage polarization. In sepsis patients, significantly elevated TLR4-TIR acetylation is observed in CD16+ monocytes combined with elevated expression of M1 macrophage markers. Pharmacological inhibition of HDAC1, which deacetylates the TIR domains, or CBP play opposite roles in sepsis. Our findings highlight the important role of TLR4-TIR domain acetylation in the regulation of the immune responses in sepsis, and we propose this reversible acetylation of TLR4 signalosomes as a potential therapeutic target for M1 macrophages during the progression of sepsis.
A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
Authors: Nagata Masahiro , Carvalho Schäfer Yasmin , Wachsmuth Laurens , Pasparakis Manolis 
Published: September 2024

AbstractZ-DNA-binding protein 1 (ZBP1) is an interferon-inducible sensor of Z-DNA and Z-RNA, which has emerged as a critical regulator of cell death and inflammation. ZBP1 binds Z-DNA and Z-RNA via its Zα domains, and signals by engaging RIPK3 and RIPK1 via its RIP homotypic interaction motifs (RHIMs). Here, we show that mice express an alternatively-spliced shorter ZBP1 isoform (ZBP1-S), which harbours the Zα domains but lacks the RHIMs, and acts as an endogenous inhibitor of the full-length protein (ZBP1-L). Mice and cells expressing only ZBP1-S are resistant to ZBP1-mediated cell death and inflammation. In contrast, cells lacking ZBP1-S show increased ZBP1-L-induced death compared to cells expressing both isoforms. Moreover, loss of the short isoform accelerates and exacerbates skin inflammation induced by ZBP1-mediated necroptosis of RIPK1-deficient keratinocytes, revealing an important physiological role of ZBP1-S. Mechanistically, ZBP1-S suppresses ZBP1-L-mediated cell death by binding to Z-nucleic acids via its Zα domains. Therefore, ZBP1-S acts as an endogenous inhibitor that competes with full-length ZBP1-L for binding Z-nucleic acid ligands to fine-tune ZBP1-mediated cell death and inflammation.
Recyclable ionic iron-substituted ceria: a precious metal-free, ligand-free, and versatile catalyst for C–C coupling and ipso-hydroxylation of arylboronic acid
Authors: Prasanna  
Published: September 2024

A recyclable precious metal-free Ce0.95Fe0.05O2-δ catalyst was synthesized by solution combustion method for selective conversion of various arylboronic acids to corresponding biphenyls and phenols employing K2S2O8 and H2O2 respectively.
Unraveling the Interplay of 5-hydroxytryptamine-3 and
N-methyl-d-aspartate Receptors in Seizure Susceptibility
Authors: Jahanabadi Samane , Madvar Mohammadreza Riahi 
Published: September 2024

Abstract
Background Epilepsy, a prevalent neurological disorder characterized by
recurrent seizures, presents significant challenges in treatment and management.
This study aimed to evaluate the effect of tropisetron, a selective 5-HT3
receptor antagonist on pentylenetetrazole (PTZ) – induced seizure in mice by
exploring the potential role of the NMDA receptor and inflammatory
responses.
Methods For this purpose, seizures were induced by intravenous PTZ
infusion. Tropisetron at 1-, 2-, 3-, 5-, 10- mg/kg were administered
intraperitoneally 30 minutes before PTZ. To evaluate probable role of NMDA
signaling, selective NMDAR antagonists, ketamine and MK-801, were injected
15 minutes before tropisetron. Also, TNF-α level of hippocampus were measured
following administration of mentioned drugs in mice.
Results Our results demonstrate that tropisetron displayed a
dose-dependent impact on seizure threshold, with certain doses (5 and 10 mg/kg)
exhibiting anticonvulsant properties. In addition, the noncompetitive NMDAR
antagonists, ketamine (1 mg/kg) and MK-801 (0.5 mg/kg), at doses that had no
effect on seizure threshold, augmented the anticonvulsant effect of tropisetron
(3 mg/kg). Also, tropisetron led to a reduction in hippocampal TNF-α levels,
indicating its anti-inflammatory potential independent of 5-HT receptor
activity.
Conclusion In conclusion, we demonstrated that the anticonvulsant effect
of tropisetron is mediated by the inhibition of NMDA receptors and a decline in
hippocampal TNF-α level. These findings highlight a potential connection between
5-HT3 and NMDA receptors in the pharmacological treatment of inflammatory
diseases, such as seizure, warranting further investigation into their combined
therapeutic effects.
Efficacy of Subperiosteal Drains in Chronic Subdural Hematoma: A Prospective Randomized Single-Center Study
Authors: Bozhkov Yavor , Feulner Julian , Buchfelder Michael , Kleiss Max , Brandner Sebastian , Kinfe Thomas M. 
Published: September 2024

Abstract
Background Chronic subdural hematomas (cSDHs) are most frequently treated by evacuation via a burr-hole craniostomy procedure. Subperiosteal drains have been introduced as alternatives to subdural ones, but only a few prospective studies have explored their efficacy. Thus, a prospective randomized trial was designed to assess their use.
Methods The study enrolled patients with newly diagnosed surgically amenable cSDH. These patients were randomized into two groups. The first group underwent cSDH evacuation via a single burr hole craniostomy procedure, followed by placement of a subperiosteal drain; the second group underwent the identical procedure without drain placement. Patient demographics, drain volumes, duration of drainage, cSDH recurrence, and postoperative outcomes were recorded.
Results Eighty-eight patients presenting with cSDH (12 with bilateral cSDHs) from a total of 100 surgical cases were enrolled. Nine patients (1 bilateral) were lost to follow-up. Of all remaining 90 procedures, 37 were carried out with drain placement and the remaining 53 without drain placement. There were five recurrent cases (13.5%) in the drain placement group and 17 (32.1%) in the group without drain placement. This resulted in a statistical significance (odds ratio [OR]: 0.33; p < 0.05) favoring the use of a drain.
Conclusion Subperiosteal drain placement can be used safely and effectively to treat cSDH in conjunction with a burr-hole craniostomy procedure, significantly reducing the rate of recurrence without any additional disadvantages.