bluuebunny/crossref_metadata_2025_split huggingface dataset:
Odontone in der Osteopathie
Authors: Pieper Matthias 
Published: June 2017

ZusammenfassungEs gibt funktionelle Bezüge zwischen Zähnen und anderen Körperregionen sowie Organsystemen. Ihre tabellarische Zusammenfassung geht auf Voll
zurück, der in den 1950er-Jahren die Elektroakupunktur entwickelte. Zum Teil lassen sich die beschriebenen Phänomene aus der Segmentanatomie
und den Kerngebieten des N. trigeminus ableiten.
Inhibitory Effect of Abitylguanide on Adenovirus Replication
Authors: Galabov Angel , Vassileva Vesselina , Karabasheva Vera 
Published: June 2017

AbstractN’N’-anhydro-bis(β-hydroxy-ethyl)biguanide.HCl (abitylguanide) demonstrated a marked inhibitory effect on replication in cell cultures of a broad spectrum of human adenoviruses both standard laboratory strains and strains isolated from epidemic keratoconjunctivitis patients. The strongest inhibitory activity was found in viruses belonging to subgroup C (Rosen’s subgroup III). The compound susceptible period of human adenovirus 5 replication in primary cell cultures of human embryo kidney cells included the total replication cycle and was especially pronounced during the exponential phase of the virus growth curve. Electron microscopy established that the compound decreased the percentage of cells in which mature or empty virions with the characteristic nuclear localization were observed; a complete absence of paracrystals was registered and the number of cells with virus particles arranged in crystals in the nucleoplasm was strongly decreased. Abitylguanide can be considered as a ligand of adenovirus capsid protein(s).
Asymmetric distribution of type IV pili triggered by directional light in unicellular cyanobacteria
Authors: Nakane Daisuke , Nishizaka Takayuki 
Published: June 2017

Significance
Type IV pili (T4P) are cell-surface appendages observed in prokaryotes that perform critical functions in cell motility, surface adhesion, virulence, and biofilm formation. Although the architecture of T4P has already been determined, the dynamics resulting from the response to various environmental signals remain unclear. Here we demonstrated the sequential process of T4P dynamics from stimulus to taxis at the single-cell level in a model cyanobacterium, which can recognize light direction. We directly visualized that T4P filaments dominantly appeared from the side of the cell opposite the illumination. This asymmetric activation is regulated on a timescale of minutes, and the process was transitioned between three sequential phases. These findings provide clues toward a general regulation mechanism of the T4P system.
Comparative studies of variation in the use of grammatical gender in the Danish and Dutch DP in the speech of youngsters
Authors: Cornips Leonie , Gregersen Frans 
Published: June 2017

Abstract
The paper reports on a cross-linguistic study on speech data produced by monolingual and bilingual Dutch and Danish teenagers. The prediction that both monolingual and bilingual Danish youngsters show less variation in grammatical gender due to more morphological input cues for gender in Danish than in Dutch is borne out. More precise results of this cross-linguistic study are that free morphemes may vary in teenagers’ actual language use in Danish whereas bound morphemes may not. Further, the teenagers produce far more common than neuter nouns in both languages and the bilinguals overuse common gender of the definite determiner in Dutch and, though demonstrably less, the indefinite determiner in Danish.
Complexity and production/comprehension asymmetries in the acquisition of wh-questions in French
Authors: Prévost Philippe , Tuller Laurice , Galloux Anne , Barthez Marie Anne 
Published: June 2017

Abstract
Assuming that production places a greater burden on processing than comprehension, this study explores the hypothesis that both the degree of linguistic computational complexity entailed in a particular structure and the processing capacity of the speakers determine if and when production/comprehension asymmetries will surface. Elicited production and comprehension of French wh-questions were studied in 29 English-speaking children acquiring French as a second language (L2) and 27 French-speaking children with Specific Language Impairment, aged 6 to 12. Results confirm the hypothesis and underline the fundamental role of complexity in language acquisition, pointing to implications for the effects of first language transfer, age of onset and length of exposure in L2 acquisition, and on differences between children with and without language pathology.
Past tense production in children with SLI and bilingual children
Authors: Rispens Judith , de Bree Elise 
Published: June 2017

Abstract
We investigated whether (1) 7–9-year-old children with SLI, bilingual children (BIL) and monolingual (TD) children differed on Dutch past tense production of real and pseudo-verbs and (2) whether non-word repetition (NWR), receptive vocabulary, and group status contributed to past tense production. Past tense patterned as SLI < BIL < TD, for NWR as SLI < BIL = TD and for vocabulary SLI = BIL < TD. Vocabulary and SLI group status were significant predictors of real-verb past tense inflection. SLI and bilingual group status were predictors of pseudo-verb past tense inflection. These findings confirm the association between vocabulary and past tense and the difficulty that children with SLI and bilingual children have with both skills.
The contribution of aromatic components in Katsuobushi to preference formation and reinforcement effect
Authors: Amitsuka Takahiko , Okamura Maya , Mukuta Kei , Shiibashi Hiroko , Haraguchi Kenji , Saito Tsukasa , Inoue Kazuo , Fushiki Tohru 
Published: June 2017

Abstract
Katsuodashi, a dried bonito broth, is very basic and indispensable in Japanese cuisine and contains taste-exhibiting components and unique aroma. We previously reported that its unique aroma contributes to the preference and reinforcement effect associated with dried bonito. This study aims to elucidate the contribution of aromatic components in Katsuobushi to preference formation and reinforcement effect. Volatile components obtained from dried bonito were fractionated and the fractions were subjected to two-bottle choice test. The fractionation test suggested that the component responsible for the preference is not one but comprises multiple components. In the GC–MS analysis/reconstruction test, solution with aromatic flavor narrowed down to 125 compounds had preference, and also had reinforcement effect. Moreover, GC–MS–olfactometry analysis narrowed down the candidate components to 28 out of 125. Mice showed preference for the test solution with aromatic flavor reconstructed with 28 components but did not show reinforcement behavior.
Poussin’s Elephant
Authors: Rice Louise 
Published: June 2017

AbstractNicolas Poussin’s “Hannibal Crossing the Alps,” long considered one of his earliest surviving works, is here recognized as a portrait of a historical elephant who visited Rome in 1630 and re-dated accordingly. The article tells the story of this remarkable animal. It traces his passage from South Asia through Portugal, Spain, England, France, the Netherlands, Germany, Austria, Italy, and back again to France, and examines his encounters along the way with kings and courtiers, scholars, artists, and traveling showmen, giving insight into the diplomatic and economic uses of exotic animals in early modern Europe. Finally, returning to Poussin, it addresses the implications of the re-dating of the “Hannibal” for our understanding of the painter’s stylistic development and biography.
Genetic Testing to Signal Quality in Beef Cattle: Bayesian Methods for Optimal Sample Size
Authors: Thompson Nathanael M. , Brorsen B. Wade , DeVuyst Eric A. , Lusk Jayson L. 
Published: June 2017

AbstractGenetic testing is one way that feeder cattle producers can credibly signal quality to buyers. However, quality signaling in the presence of asymmetric information typically requires paying measurement costs. Given that previous research has indicated that the value of genetic information is generally not enough to offset the current cost of testing, we evaluate random sampling as a strategy to reduce the overall cost of testing. An economic approach to sample size determination is introduced utilizing a Bayesian decision theoretic framework to balance the expected costs and benefits of sampling. Data from 101 pens (2,796 animals) of commercially‐fed cattle are used to empirically evaluate optimal sampling. Assuming profit is linear (nonlinear) in genetic information, results indicate that at the baseline parameter values an optimal sample size of nine (five) out of 100 animals generates returns from sampling of $7.87/head ($5.96/head). Sensitivity analyses indicate that the degree of asymmetric information (absolute difference between seller and buyer prior expectations of quality) is the major driver of the overall results. The results provide strong evidence that random sampling generates benefits that far exceed the costs.
Endobronchial brachytherapy with curative intent: the impact of reference points setting according to the bronchial diameter
Authors: Nomoto Yoshihito , Ii Noriko , Murashima Shuichi , Yamashita Yasufumi , Ochiai Satoru , Takada Akinori , Toyomasu Yutaka , Kawamura Tomoko , Sakuma Hajime 
Published: June 2017

Abstract
Endobronchial brachytherapy (EBB) is an effective treatment for endobronchial tumors. However, bronchial toxicity caused by over-irradiation remains problematic. To decrease bronchial toxicity, we developed a source-centralizing applicator for EBB. The purpose of the present study was to assess the efficacy and safety of EBB with varying reference dose points according to the bronchial diameter, using a source-centralizing applicator. We reviewed 15 patients with endobronchial carcinoma who were treated with curative intent using a combination of external beam radiotherapy (EBRT) and high-dose-rate EBB between 2005 and 2014. During each EBB session, we used a source-centralizing applicator that maintained the source-delivering catheter in the center of the bronchial lumen. Reference dose points were 5–7 mm from the source axis, depending on the bronchial diameter. The median radiation doses of EBRT and EBB were 40 Gy in 20 fractions and 18 Gy in 3 fractions, respectively. The median observation period was 36 months. The 3-year overall survival, progression-free survival and local control rates were 79%, 77% and 100%, respectively. Grade 2 radiation pneumonitis was observed in two cases. Bronchial toxicities, such as hemoptysis or the symptoms of chronic bronchitis, were not observed. EBB with varying reference dose points according to bronchial diameter, using a source-centralizing applicator, is a promising procedure that may be effective for tumor elimination and reducing toxicity to the bronchial wall.
Failure to Rescue and Mortality Following Resection of Intracranial Neoplasms
Authors: Malone Hani , Cloney Michael , Yang Jingyan , Hershman Dawn L , Wright Jason D , Neugut Alfred I , Bruce Jeffrey N 
Published: June 2017

AbstractBACKGROUNDThere is growing recognition that perioperative complication rates are similar between hospitals, but mortality rates are lower at high-volume centers. This may be due to differences in the ability to rescue patients from major complications.OBJECTIVETo examine the relationship between hospital caseload and failure to rescue from complications following resection of intracranial neoplasms.METHODSWe identified adults in the Nationwide Inpatient Sample diagnosed with glioma, meningioma, brain metastasis, or acoustic neuroma, who underwent surgical resection between 1998 and 2010. We stratified hospitals by low, intermediate, and high surgical volume tertiles and calculated failure to rescue rates (mortality in patients after a major complication).RESULTSA total of 550 054 patients were analyzed. Overall risk-adjusted complication rates were comparable between low- and medium-volume centers, and slightly lower at high-volume centers (15.3% [15.2, 15.5] vs 15.7% [15.5, 15.9] vs 14.3% [14.1, 14.6]). Risk-adjusted mortality decreased with increasing hospital surgical volume (10.3% [10.2, 10.5] vs 9.0% [8.9, 9.1] vs 7.1% [7.0, 7.2]). The overall risk-adjusted failure to rescue rate also decreased with increasing surgical volume (26.9% [26.3, 27.4] vs 24.8% [24.3, 25.3] vs 20.9% [20.5, 21.5]).CONCLUSIONWhile complication rates were similar between high-volume and low-volume hospitals following craniotomy for tumor, mortality rates were substantially lower at high-volume centers. This appears to be due to the ability of high-volume hospitals to rescue patients from major perioperative complications.
Posterior Reversible Encephalopathic Syndrome in the Setting of Induced Elevated Mean Arterial Pressure in Patients With Spinal Cord Injury
Authors: Whiting Alexander C , Fanarjian Manuel P , Hlubek Randall J , Godzik Jakub , Kakarla U Kumar , Theodore Nicholas 
Published: June 2017

Abstract

BACKGROUND AND IMPORTANCE
Acute spinal cord injury (SCI) is managed by avoiding hypotension and elevating mean arterial pressure (MAP) to attain optimal perfusion of the spinal cord. Few studies have been published regarding complications related to this treatment paradigm.

CLINICAL PRESENTATION
Three patients with SCI developed posterior reversible encephalopathic syndrome (PRES) during treatment with intravenous fluids and vasopressors administered to maintain elevated MAPs. All of them experienced temporary elevations well above the standard blood pressure goals for acute SCI and deterioration of neurological status.

CONCLUSION
PRES is a potential complication of elevated MAPs in patients with SCI, particularly if the blood pressure rises above the goals of standard treatment paradigms. The neurosurgical staff should be suspicious of possible PRES early in the course of acute SCI in patients with unexplained neurological decline. This case series is the first report of PRES in patients with acute SCI.
Is Traditional Closed Thoracic Drainage Necessary to Treat Pleural Tears After Posterior Approach Thoracic Spine Surgery?
Authors: Zheng Guo-li , Zhou Hao , Zhou Xiao-Gang , Lin Hong , Li Xi-lei , Dong Jian 
Published: June 2017

Study Design.
A prospective study.

Objective.
The aim of this study was to evaluate the outcomes and efficacy of using a 10Fr elastic tube with a regular negative pressure ball to treat the operative pleural tear in the complicated single-stage posterior approach thoracic spine surgeries.

Summary of Background Data.
In some complicated single-stage posterior approach thoracic spine surgeries, such as total en bloc spondylectomy, pleural tear is quite inevitable. Traditional chest tube with a water-sealed bottle has many shortcomings, as pain, inconvenience, and other complications. In many thoracic surgeries, a smaller-caliber elastic tube has been used to avoid such complications and achieve quick recovery. However, there are concerns about the efficacy and safety of the smaller-caliber elastic tube.

Methods.
A prospective trial was performed in 72 patients between April 2008 and March 2012. Pleural tear occurred in 19 patients, among whom 10 patients were inserted a 10Fr elastic tube with a regular negative pressure ball (Group I), and nine were inserted a 28Fr chest tube with a water-sealed bottle (Group II). Comparative evaluation of the clinical and radiographic data was carried out.

Results.
The basic condition of two groups did not differ significantly. The oxygen saturation monitor, hospital length of stay, average volume, and failure rate of drainage between two groups were not statistically significant. The difference of the visual analog score was significant (1.10 ± 0.35 vs. 3.89 ± 0.59, P < 0.001).

Conclusion.
Patients who received a 10Fr elastic tube with a regular negative pressure ball experienced less pain and a tendency of quicker recovery than those who received a 28Fr chest tube with a water-sealed bottle. The complication rate in Group I was not higher than Group II, indicating an equally good drainage efficacy.

Level of Evidence: 2
Two cases of epithelioid trophoblastic tumors in postmenopausal women
Authors: Rodríguez-Trujillo Adriano , Martínez-Serrano María José , Saco Adela , Torné Aureli 
Published: June 2017

Abstract

Objective:
Epithelioid trophoblastic tumor is a rare gestational trophoblastic neoplasm usually presenting in women of reproductive age, with a history of a prior gestational event. Its presentation in postmenopausal women is extremely rare. Immunohistochemical staining is a helpful aid to distinguish epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. Correct diagnosis is crucial for clinical management that can vary according to the type of gestational trophoblastic neoplasm.

Methods:
We report the case of a 63-year-old postmenopausal woman 33 years after her last full-term pregnancy and another case of a 57-year-old postmenopausal woman who had had a first-trimester abortion 30 years previously as her last gestational event, both presenting cervical epithelioid trophoblastic tumors. In both cases, immunohistochemistry played an important role in differentiating this entity from other gestational trophoblastic neoplasms. Surgery was the primary treatment in both cases. The first patient remained disease-free and died 5 years later due to a rectal adenocarcinoma, and the second patient remains disease-free at publication.

Results:
In both cases, the hysterectomy specimen confirmed the presence of two large epithelioid trophoblastic tumors arising in the endocervix and lower uterine segment with no extrauterine disease. Nuclear positivity for p63 allowed differentiation from a placental site trophoblastic tumor. The Ki67 proliferative index was 20% and 35%, respectively.

Conclusions:
Epithelioid trophoblastic tumors may occur a long time after a prior gestational event and should even be excluded in postmenopausal women with uterine masses. Immunohistochemical staining is helpful to make the differential diagnosis with other gestational trophoblastic neoplasms.
Selective Localized Tenonplasty for Corneal Burns Based on the Findings of Ocular Surface Fluorescein Angiography
Authors: Tabatabaei Seyed Ali , Soleimani Mohammad , Mirshahi Reza , Zandian Mehdi , Ghasemi Hamed , Hashemian Mohammad Naser , Ghomi Zahra 
Published: June 2017

Purpose:
To report the results of a selective localized tenonplasty procedure based on findings of ocular surface fluorescein angiography (FA).

Methods:
Six consecutive patients with severe chemical burns were included in this study. Using fluorescein angiogram images, patients underwent selective localized tenonplasty to cover the identified ischemic areas in FA.

Results:
FA 1 week after surgery showed a perfused ocular surface in all eyes except for 1 quadrant of limbal ischemia in 1 eye. After the second tenonplasty, recirculation was also detected in that quadrant. None of the eyes perforated during the follow-up period.

Conclusions:
We observed acceptable outcomes in our patients after selective tenonplasty based on ocular surface angiography.
Neurophysiological Effects of Bitopertin in Schizophrenia
Authors: Kantrowitz Joshua T. , Nolan Karen A. , Epstein Michael L. , Lehrfeld Nayla , Shope Constance , Petkova Eva , Javitt Daniel C. 
Published: June 2017

Abstract

Purpose/Background
Deficits in N-methyl-d-aspartate receptor (NMDAR) function contribute to symptoms and cognitive dysfunction in schizophrenia and are associated with impaired generation of event-related potential measures including auditory mismatch negativity. Parallel studies of the NMDAR agonist d-serine have suggested that sensitivity of these measures to glutamate-based interventions is related to symptomatic and cognitive response. Bitopertin is a selective inhibitor of glycine transport. This study investigates effects of bitopertin on NMDAR-related event-related potential deficits in schizophrenia.

Methods/Procedures
Patients with schizophrenia/schizoaffective disorder were treated with bitopertin (10 mg, n = 29), in a double-blind, parallel group investigation. Auditory mismatch negativity served as primary outcome measures. Secondary measures included clinical symptoms and neurocognitive performance.

Findings/Results
No significant changes were seen with bitopertin for neurophysiological, clinical, or neurocognitive assessments.

Implications/Conclusions
These findings represent the first assessment of the effect of bitopertin on neurophysiological biomarkers. Bitopertin did not significantly affect either symptoms or NMDAR-related biomarkers at the dose tested (10 mg). Mismatch negativity showed high test-retest reliability, supporting its use as a target engagement measure.
The Efficacy of Psychostimulants in Major Depressive Episodes
Authors: McIntyre Roger S. , Lee Yena , Zhou Aileen J. , Rosenblat Joshua D. , Peters Evyn M. , Lam Raymond W. , Kennedy Sidney H. , Rong Carola , Jerrell Jeanette M. 
Published: June 2017

Background
Psychostimulants are frequently prescribed off-label for adults with major depressive disorder or bipolar disorder. The frequent and increasing usage of stimulants in mood disorders warrants a careful appraisal of the efficacy of this class of agents. Herein, we aim to estimate the efficacy of psychostimulants in adults with unipolar or bipolar depression.

Methods
The PubMed/Medline database was searched from inception to January 16, 2016 for randomized, placebo-controlled clinical trials investigating the antidepressant efficacy of psychostimulants in the treatment of adults with unipolar or bipolar depression.

Results
Psychostimulants were associated with statistically significant improvement in depressive symptoms in major depressive disorder (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.13–1.78; P = 0.003) and bipolar disorder (OR, 1.42; 95% CI, 1.13–1.78; P = 0.003). Efficacy outcomes differed across the psychostimulants evaluated as a function of response rates: ar/modafinil (OR, 1.47; 95% CI, 1.20–1.81; P = 0.0002); dextroamphetamine (OR, 7.11; 95% CI, 1.09–46.44; P = 0.04); lisdexamfetamine dimesylate (OR, 1.21; 95% CI, 0.94–1.56; P = ns); methylphenidate (OR, 1.49; 95% CI, 0.88–2.54; P = ns). Efficacy outcomes also differed between agents used as adjunctive therapy (OR, 1.39; 95% CI, 1.19–1.64) or monotherapy (OR, 2.25; 95% CI, 0.67–7.52).

Conclusions
Psychostimulants are insufficiently studied as adjunctive or monotherapy in adults with mood disorders. Most published studies have significant methodological limitations (eg, heterogeneous samples, dependent measures, type/dose of agent). In addition to improvements in methodological factors, a testable hypothesis is that psychostimulants may be more appropriately tested in select domains of psychopathology (eg, cognitive emotional processing), rather than as “broad-spectrum” antidepressants.