bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban households' engagement in agriculture: implications for household food security in Ghana's medium sized cities
Authors: Ayerakwa Hayford Mensah 
Published: January 2017

AbstractUrban and peri‐urban agriculture plays an important role in meeting the food and nutrition needs of those living in the increasingly urbanised cities in Africa. The extent and scope of the practise of urban and peri‐urban agriculture differs from one city to another depending on the economic, environmental, socio‐political, and contextual conditions at play. Using household data drawn from urban Techiman and Tamale in the Brong Ahafo and Northern regions of Ghana respectively, this paper descriptively analyses the contribution of households' engagement in agriculture on urban households' food security. The results show that, nearly half (43%) of urban residents are involved in the production of food either in the urban or rural areas or both, primarily for household consumption and sale of surplus produce. Households who do not engage in agriculture raise their cash incomes through engagement in informal businesses. The picture is however different for households that engage in urban and rural agriculture. For such households, income raised from agriculture (rural and urban combined) is the highest in both cities contributing nearly half (43%) and about a third (33%) of total cash incomes in Techiman and Tamale respectively. The results underscore the need to place the discussion on the contribution of urban agriculture to urban food security in the broader context of the different food production arrangements available to urban households, both in urban and rural areas.
Contested geographies: competing constructions of community and efficiency in small school debates
Authors: Corbett Michael , Helmer Leif 
Published: January 2017

AbstractThe history of rural education in North America can be understood as a history of school closure, amalgamation, and consolidation of schools. Typically, historical and geographical arguments have converged in debates about whether or not to close small community schools, which are positioned as the victims of the march of time and reconfiguration of space. In this paper, we analyse the archetypical positioning of rural parents in the ‘school wars’ as emotional and irrational participants who want to turn back time and who fail or refuse to understand and accept what is alleged to be the inevitable transformation of rural space. We then analyse the political strategy and tactics engaged in by school governance officials and community agents in these struggles over the meaning and future of rural space. We argue that the confrontational politics that ensues do not support strong rural development conversations and that the unilateral search for what we call ‘trump cards’ to settle arguments with data and rational or emotional ‘appeals’ has led to ongoing tension in rural communities.
Influence of Package Visual Cues of Sweeteners on the Sensory‐Emotional Profiles of Their Products
Authors: Wardy Wisdom , Chonpracha Pitchayapat , Chokumnoyporn Napapan , Sriwattana Sujinda , Prinyawiwatkul Witoon , Jirangrat Wannita 
Published: January 2017

AbstractSubstantial evidence suggests influence of color, physical state, and other extrinsic features on consumer perception and acceptability of food products. In this study, 560 subjects evaluated liking and emotional responses associated with 5 sweeteners (sucralose, stevia, saccharin, aspartame, and sucrose) under 2 eliciting conditions: control (brand name only) and informed (brand name/packet image), to assess impact of the packet color. For a given condition, 5 identical tea samples each labeled with a sweetener type were rated for sweetness and overall liking (9‐point) and emotions (5‐point). Nonsignificant interactions between eliciting condition and sweetener type were found for liking attributes and emotions (except peaceful), indicating their independent effects. However, overall differences existed among sweetener types and eliciting conditions based on both hedonic and emotional responses (MANOVA, P < 0.05), suggesting modulating effects of packet color on sweetener type in the sensory‐emotion space. The sensory‐emotion profile for sucrose was separate from that of nonnutritive sweeteners, with statistically significant Mahalanobis distances among sample centroids. Increases in positive emotion intensities contrasted with a decrease in negative emotion intensities were observed for some sweeteners moving from the control to informed condition. Sweetness liking was strongly correlated with the emotion satisfied (sucralose, saccharin) only in the control condition, whereas it was strongly correlated with the emotions pleased and satisfied (stevia), disgusted (aspartame), and satisfied (sucrose) only in the informed condition. Overall, results suggested that sensory liking and emotions during the consumption experience are related not entirely to the type of sweetener, but also the color of the packet.
The Watershed Flow and Allocation Model: An NHDPlus‐Based Watershed Modeling Approach for Multiple Scales and Conditions
Authors: Eddy Michele C. , Moreda Fekadu G. , Dykes Robert M. , Bergenroth Brandon , Parks Aaron , Rineer James 
Published: January 2017

AbstractThe Watershed Flow and Allocation model (WaterFALL®) provides segment‐specific, daily streamflow at both gaged and ungaged locations to generate the hydrologic foundation for a variety of water resources management applications. The model is designed to apply across the spatially explicit and enhanced National Hydrography Dataset (NHDPlus) stream and catchment network. To facilitate modeling at the NHDPlus catchment scale, we use an intermediate‐level rainfall‐runoff model rather than a complex process‐based model. The hydrologic model within WaterFALL simulates rainfall‐runoff processes for each catchment within a watershed and routes streamflow between catchments, while accounting for withdrawals, discharges, and onstream reservoirs within the network. The model is therefore distributed among each NHDPlus catchment within the larger selected watershed. Input parameters including climate, land use, soils, and water withdrawals and discharges are georeferenced to each catchment. The WaterFALL system includes a centralized database and server‐based environment for storing all model code, input parameters, and results in a single instance for all simulations allowing for rapid comparison between multiple scenarios. We demonstrate and validate WaterFALL within North Carolina at a variety of scales using observed streamflows to inform quantitative and qualitative measures, including hydrologic flow metrics relevant to the study of ecological flow management decisions.
Evaluating Flow Metric‐Based Stream Classification Systems to Support the Determination of Ecological Flows in North Carolina
Authors: Eddy Michele C. , Phelan Jennifer , Patterson Lauren , Allen Jessie , Pearsall Sam 
Published: January 2017

AbstractHydroecological classification systems are typically based on an assemblage of streamflow metrics and seek to divide streams into ecologically relevant classes. Assignment of streams to classes is suggested as an initial step in the process of establishing ecological flow standards. We used two distinct hydroecological river classification systems available within North Carolina to evaluate the ability of a hydrologic model to assign the same classes as those determined by observed streamflows and to assess the transferability of such systems to ungaged streams. Class assignments were examined by rate of overall matches, rate of class matches, spatial variability in matches, and time period used in class assignment. The findings of this study indicate assignments of stream class: (1) are inconsistent among different classification systems; (2) differ between observed and modeled data; and (3) are sensitive to the period of record within observed data. One clear source of inconsistency/sensitivity in class assignments lies with the use of threshold values for metrics that distinguish stream classes, such that even small changes in metric values can result in different class assignments. Because these two hydroecological classification systems are representative of other classification systems that rely on quantitative decision thresholds, it can be surmised that the use of such systems based on stream flow metrics is not a reliable approach for guiding ecological flow determinations.
A national survey of neurological monitoring practice after obstetric regional anaesthesia in the UK
Authors: Roderick E. , Hoyle J. , Yentis S. M. 
Published: January 2017

SummaryNeuraxial anaesthesia is widely used in obstetrics and neurological complications are rare. However, when they occur, subsequent investigation and management are time‐critical and correlate with the extent of neurological recovery. The Third National Audit Project recommended the implementation of guidelines in obstetric epidural management, including advice on monitoring for early signs of problems and acting upon concerns. However, no national guideline exists for postoperative management in the obstetric population. We conducted a national survey of monitoring after obstetric neuraxial blockade and the management of an abnormally prolonged block. We received responses from 112/189 (59.3%) obstetric anaesthetic leads invited to participate. We determined that post‐neuraxial blockade monitoring in the UK is highly variable: only 63/112 (56.3%) respondents’ units had a monitoring policy in place, although most of these did not undertake formal neurological monitoring, and a range of different monitoring methods and schedules were employed. In 12/63 (19%) local policies, the first review of neurology was performed at the standard postoperative visit the following day, and 66/112 (58.9%) units had no protocol in place to address emergency management of abnormally prolonged neuraxial blockade. Where a policy was in place, the initial recommended action and the type of imaging used were variable.
Pharmacokinetics of obinutuzumab in Chinese patients with B‐cell lymphomas
Authors: Zhai John , Qin Yan , Zhu Jun , Song Yuqin , Shen Zhixiang , Du Xin , Jamois Candice , Brewster Michael , Shi Yuankai , Shi Jun 
Published: January 2017

AimThe Phase Ib GERSHWIN study (NCT01680991) assessed the pharmacokinetic (PK) profile of obinutuzumab following multiple intravenous (i.v.) doses to Chinese patients with B‐cell lymphomas, and compared findings with previous obinutuzumab PK studies in mainly Caucasian (non‐Chinese) patients.MethodsGERSHWIN was an open‐label, single‐arm intervention study. Patients aged >18 years with CD20+ relapsed/refractory chronic lymphocytic leukaemia (CLL), diffuse large B‐cell lymphoma (DLBCL) or follicular lymphoma (FL) were enrolled from four centres in China. The treatment period was 24 weeks; patients received obinutuzumab 1000 mg i.v. on Days (D)1, 8 and 15 of Cycle (C)1 (CLL patients: first infusion split over 2 days) and on D1 of C2–8 (all cycles: 21 days). PK parameters were estimated using non‐compartmental analysis (NCA), and a population PK analysis was used to determine whether observed GERSHWIN PK data were in accordance with previous obinutuzumab PK studies in non‐Chinese patients.ResultsThe PK analysis population included 48 patients: 28 patients completed all treatment cycles. NCA showed a similar PK profile in Chinese patients with FL, DLBCL and CLL. Steady‐state concentrations of obinutuzumab appeared to be reached at the start of C2 irrespective of histology. There was no apparent relationship between body weight and systemic exposure. Most PK profiles observed in GERSHWIN lay within the 90% prediction interval of simulated profiles.ConclusionsObinutuzumab exposure was comparable in CLL, DLBCL and FL patients. NCA and population PK analysis indicate that PK characteristics of Chinese patients with B‐cell lymphomas are similar to those in non‐Chinese patients.
Safety profile of the direct oral anticoagulants: an analysis of the WHO database of adverse drug reactions
Authors: Monaco Luca , Biagi Chiara , Conti Valentino , Melis Mauro , Donati Monia , Venegoni Mauro , Vaccheri Alberto , Motola Domenico 
Published: January 2017

AimDirect oral anticoagulants (DOACs) have shown noninferiority to warfarin for stroke prevention in nonvalvular atrial fibrillation (AF) and a more promising safety profile. Unanswered safety aspects remain to be addressed and available evidence on the risk associated with these drugs are conflicting. In order to contribute to the debate on their safety profile, we conducted a comparative analysis of the reports of suspected adverse drug reactions (ADRs) associated with DOACs in VigiBase.MethodsStudy based on reports of suspected ADRs held in VigiBase as at December 2014, in which a DOAC or warfarin were administered in patients with nonvalvular AF and listed as suspected/interacting drugs. Medical Dictionary for Regulatory Activities was used to classify ADRs. Reporting odds ratio (ROR) with 95% confidence interval were calculated. Results with P ≤ 0.05 were statistically significant.ResultsWe retrieved 32 972 reports. We identified 204 ADRs with a ROR >1 (P ≤ 0.05) and we focused on 105 reactions. Positive ROR emerged for DOACs and gastrointestinal haemorrhage compared with warfarin [(1.6 (1.47–1.75)], but no disproportionality with cerebral haemorrhage was found [0.31 (0.28–0.34)]. We identified other potential signals that have not been associated with DOACs previously.ConclusionsAs well as premarketing authorization clinical trial studies, we found a reduced risk of intracranial haemorrhage, but an increased risk of gastrointestinal haemorrhage in patients treated with DOACs compared to warfarin. We provide new data and we highlight several differences between the three novel oral anticoagulants, in the rate and type of ADRs occurred
Aspirin‐triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E−/− mice
Authors: Petri Marcelo H , Laguna‐Fernandez Andrés , Arnardottir Hildur , Wheelock Craig E , Perretti Mauro , Hansson Göran K , Bäck Magnus 
Published: January 2017

Background and PurposeAtherosclerosis is characterized by a chronic non‐resolving inflammation in the arterial wall. Aspirin‐triggered lipoxin A4 (ATL) is a potent anti‐inflammatory mediator, involved in the resolution of inflammation. However, the therapeutic potential of immune targeting by means of ATL in atherosclerosis has not previously been explored. The aim of the present study was to determine the effects of ATL and its receptor Fpr2 on atherosclerosis development and progression in apolipoprotein E deficient (ApoE−/−) mice.Experimental ApproachApoE−/− × Fpr2+/+ and ApoE−/− × Fpr2−/− mice were generated. Four‐week‐old mice fed a high‐fat diet for 4 weeks and 16‐week‐old mice fed chow diet received osmotic pumps containing either vehicle or ATL for 4 weeks. Atherosclerotic lesion size and cellular composition were measured in the aortic root and thoracic aorta. Lipid levels and leukocyte counts were measured in blood and mRNA was isolated from abdominal aorta and spleen.Key ResultsATL blocked atherosclerosis progression in the aortic root and thoracic aorta of ApoE−/− mice. In addition, ATL reduced macrophage infiltration and apoptotic cells in atherosclerotic lesions. The mRNA levels of several cytokines and chemokines in the spleen and aorta were reduced by ATL, whereas circulating leukocyte levels were unchanged. The ATL‐induced athero‐protection was absent in ApoE−/− mice lacking the Fpr2 receptor.Conclusion and ImplicationsATL blocked atherosclerosis progression by means of an Fpr2‐mediated reduced local and systemic inflammation. These results suggest this anti‐inflammatory and pro‐resolving agent has therapeutic potential for the treatment of atherosclerosis.Linked ArticlesThis article is part of a themed section on Targeting Inflammation to Reduce Cardiovascular Disease Risk. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.22/issuetoc and http://onlinelibrary.wiley.com/doi/10.1111/bcp.v82.4/issuetoc
Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response?
Authors: Goszcz Katarzyna , Duthie Garry G , Stewart Derek , Leslie Stephen J , Megson Ian L 
Published: January 2017

Polyphenols are widely regarded to have a wide range of health‐promoting qualities, including beneficial effects on cardiovascular disease. Historically, the benefits have been linked to their well‐recognized powerful antioxidant activity. However, the concept that the beneficial effects are attributable to direct antioxidant activity in vivo does not pay sufficient heed to the fact that polyphenols degrade rapidly, are poorly absorbed and rapidly metabolized, resulting in very low bioavailability. This review explores alternative mechanisms by which polyphenols, or their metabolites, exert biological activity via mechanisms that can be activated by physiologically relevant concentrations. Evidence is presented to support the action of phenolic derivatives on receptors and signalling pathways to induce adaptive responses that drive changes in endogenous antioxidant, antiplatelet, vasodilatory and anti‐inflammatory effects. The implications are that in vitro antioxidant measures as predictors of polyphenol protective activity in vivo hold little relevance and that closer attention needs to be paid to bioavailable metabolites to understand the mode of action of these diet‐derived components.Linked ArticlesThis article is part of a themed section on Principles of Pharmacological Research of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc
Functional and cardioprotective effects of simultaneous and individual activation of protein kinase A and Epac
Authors: Khaliulin Igor , Bond Mark , James Andrew F , Dyar Zara , Amini Raheleh , Johnson Jason L , Suleiman M‐Saadeh 
Published: January 2017

Background and PurposeMyocardial cAMP elevation confers cardioprotection against ischaemia/reperfusion (I/R) injury. cAMP activates two independent signalling pathways, PKA and Epac. This study investigated the cardiac effects of activating PKA and/or Epac and their involvement in cardioprotection against I/R.Experimental ApproachHearts from male rats were used either for determination of PKA and PKC activation or perfused in the Langendorff mode for either cardiomyocyte isolation or used to monitor functional activity at basal levels and after 30 min global ischaemia and 2 h reperfusion. Functional recovery and myocardial injury during reperfusion (LDH release and infarct size) were evaluated. Activation of PKA and/or Epac in perfused hearts was induced using cell permeable cAMP analogues in the presence or absence of inhibitors of PKA, Epac and PKC. H9C2 cells and cardiomyocytes were used to assess activation of Epac and effect on Ca2+ transients.Key ResultsSelective activation of either PKA or Epac was found to trigger a positive inotropic effect, which was considerably enhanced when both pathways were simultaneously activated. Only combined activation of PKA and Epac induced marked cardioprotection against I/R injury. This was accompanied by PKCε activation and repressed by inhibitors of PKA, Epac or PKC.Conclusion and ImplicationsSimultaneous activation of both PKA and Epac induces an additive inotropic effect and confers optimal and marked cardioprotection against I/R injury. The latter effect is mediated by PKCε activation. This work has introduced a new therapeutic approach and targets to protect the heart against cardiac insults.
Cognitive Stress Reduces the Effect of Levodopa on Parkinson's Resting Tremor
Authors: Zach Heidemarie , Dirkx Michiel F. , Pasman Jaco W. , Bloem Bastiaan R. , Helmich Rick C. 
Published: January 2017

SummaryAimsResting tremor in Parkinson′s disease (PD) increases markedly during cognitive stress. Dopamine depletion in the basal ganglia is involved in the pathophysiology of resting tremor, but it is unclear whether this contribution is altered under cognitive stress. We test the hypothesis that cognitive stress modulates the levodopa effect on resting tremor.MethodsTremulous PD patients (n = 69) were measured in two treatment conditions (OFF vs. ON levodopa) and in two behavioral contexts (rest vs. cognitive co‐activation). Using accelerometry, we tested the effect of both interventions on tremor intensity and tremor variability.ResultsLevodopa significantly reduced tremor intensity (across behavioral contexts), while cognitive co‐activation increased it (across treatment conditions). Crucially, the levodopa effect was significantly smaller during cognitive co‐activation than during rest. Resting tremor variability increased after levodopa and decreased during cognitive co‐activation.ConclusionCognitive stress reduces the levodopa effect on Parkinson's tremor. This effect may be explained by a stress‐related depletion of dopamine in the basal ganglia motor circuit, by stress‐related involvement of nondopaminergic mechanisms in tremor (e.g., noradrenaline), or both. Targeting these mechanisms may open new windows for treatment. Clinical tremor assessments under evoked cognitive stress (e.g., counting tasks) may avoid overestimation of treatment effects in real life.
Land use controls stream ecosystem metabolism by shifting dissolved organic matter and nutrient regimes
Authors: Fuß Thomas , Behounek Barbara , Ulseth Amber J. , Singer Gabriel A. 
Published: January 2017

Summary

Stream ecosystem metabolism integrates production and respiration of organic matter and plays a fundamental role in the global carbon (C) cycle. Several studies have identified distal and proximal physical controls, for example, land use and transient storage, or the effects of water chemistry, that is, organic matter and nutrient availability, on stream metabolism. In parallel, research on organic matter quality has identified conspicuous gradients of chemical composition, yet mostly without demonstrating any functional implications.

We hypothesise that organic matter holds a key position in a more comprehensive causal framework of stream ecosystem metabolism, and that a concurrent study can improve mechanistic understanding. Specifically, we here postulate that dissolved organic matter (DOM) quality, that is, its chemical composition, acts as a control of ecosystem respiration (ER) as much as it is a result of gross primary production (GPP). As such, DOM quality likely forms a central link between land use and stream metabolism, besides known physical controls including transient storage and light availability.

To examine these hypotheses, we studied 33 streams in north‐eastern Austria, a region with diverse land use ranging from semi‐natural, forested areas to agricultural areas and settlements. We analysed DOM composition by absorbance and fluorescence spectroscopy, including modelling excitation–emission matrices with parallel factor analysis. We then opposed these data to GPP and ER estimated by fitting a metabolism model to single‐station diurnal oxygen records.

Structural equation modelling revealed land use as a control on light conditions, DOM composition and concentration and nutrient concentrations, which together ultimately shaped GPP and ER. In particular, humified, coloured and aromatic DOM of predominantly terrestrial origin was prevalent in coniferous forest catchments and increased stream ER. Agricultural and urban areas enriched streams with phosphorous and nitrogen, which increased ER and GPP. Besides nutrients, GPP seemed to be weakly correlated with light availability and – in contrast to our hypothesis – left only a weak imprint on DOM composition.

Land‐use change is rated as the most pervasive human influence on natural ecosystems and our results highlight its impact on aquatic GPP and ER in streams. To understand the role of inland waters in the global C cycle will require mechanistic understanding of ecosystem metabolism, which notably includes organic matter quality as a hitherto underappreciated key player.