bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing mechanical properties of wires by a novel continuous severe plastic deformation method
Authors: Pourbashiri Mojtaba , Sedighi Mohammad , Poletti Cecilia , Sommitsch Christof 
Published: August 2017

Abstract
Commercially pure Al wires are severely plastic deformed by a novel method called equal channel angular torsion drawing (ECATD) up to four passes. Initial wires are drawn through an equal channel angular die and simultaneously torsion deformed by turning the ECATD die. The wires are deformed up to an equivalent strain of 1 to 4 (based on FE result) at room temperature. The microstructural evolution of the wires is investigated using optical microscopy of both longitudinal and transverse cross-sections. A grain refinement from 100 μm to a mean grain size of 1–10 μm is achieved mainly at the areas near the surface of the wires. A decreasing trend of grain refinement is observed from the edge area to the wire center due to the non-uniform strain distribution, resulting in an inhomogeneous hardness. A significant increase in hardness is obtained from ∼22 HV to ∼43 HV at the wire center and to ∼60 HV at the wire edge, this confirms simulated equivalent plastic strain. The most important advantage of this process is the ability to impose continuous large plastic deformation on wires. It can be used as an industrial method for continuous strain hardening and grain refinement of wires.
Rapid nickel diffusion in cold-worked type 316 austenitic steel at 360–500 °C
Authors: Arioka Koji , Iijima Yoshiaki , Miyamoto Tomoki 
Published: August 2017

Abstract
The diffusion coefficient of nickel in cold-worked Type 316 austenitic steel was determined by the diffusion couple method in the temperature range between 360 and 500 °C. A diffusion couple was prepared by electroless nickel plating on the surface of a 20 % cold-worked Type 316 austenitic steel specimen. The growth in width of the interdiffusion zone was proportional to the square root of diffusion time until 14 055 h. The diffusion coefficient of nickel (D
Ni) in cold-worked Type 316 austenitic steel was determined by extrapolating the concentration-dependent interdiffusion coefficient to 11 at.% of nickel. The value of D
Ni at 360 °C was about 5 000 times higher than the lattice diffusion coefficient of nickel in Type 316 austenitic steel. The determined activation energy 117 kJ mol−1 was 46.6 % of the activation energy 251 kJ mol−1 for the lattice diffusion of nickel in Type 316 austenitic steel.
The Little Cub: Discovery of an Extremely Metal-poor Star-forming Galaxy in the Local Universe
Authors: Hsyu Tiffany , Cooke Ryan J. , Prochaska J. Xavier , Bolte Michael 
Published: August 2017

Abstract
We report the discovery of the Little Cub, an extremely metal-poor star-forming galaxy in the local universe, found in the constellation Ursa Major (a.k.a. the Great Bear). We first identified the Little Cub as a candidate metal-poor galaxy based on its Sloan Digital Sky Survey photometric colors, combined with spectroscopy using the Kast spectrograph on the Shane 3 m telescope at Lick Observatory. In this Letter, we present high-quality spectroscopic data taken with the Low Resolution Imaging Spectrometer at Keck Observatory, which confirm the extremely metal-poor nature of this galaxy. Based on the weak [O iii] λ4363 Å emission line, we estimate a direct oxygen abundance of 12 + log(O/H) = 7.13 ± 0.08, making the Little Cub one of the lowest-metallicity star-forming galaxies currently known in the local universe. The Little Cub appears to be a companion of the spiral galaxy NGC 3359 and shows evidence of gas stripping. We may therefore be witnessing the quenching of a near-pristine galaxy as it makes its first passage about a Milky Way–like galaxy.
Extended Subadiabatic Layer in Simulations of Overshooting Convection
Authors: Käpylä Petri J. , Rheinhardt Matthias , Brandenburg Axel , Arlt Rainer , Käpylä Maarit J. , Lagg Andreas , Olspert Nigul , Warnecke Jörn 
Published: August 2017

Abstract
We present numerical simulations of hydrodynamic overshooting convection in local Cartesian domains. We find that a substantial fraction of the lower part of the convection zone (CZ) is stably stratified according to the Schwarzschild criterion while the enthalpy flux is outward directed. This occurs when the heat conduction profile at the bottom of the CZ is smoothly varying, based either on a Kramers-like opacity prescription as a function of temperature and density or a static profile of a similar shape. We show that the subadiabatic layer arises due to nonlocal energy transport by buoyantly driven downflows in the upper parts of the CZ. Analysis of the force balance of the upflows and downflows confirms that convection is driven by cooling at the surface. We find that the commonly used prescription for the convective enthalpy flux being proportional to the negative entropy gradient does not hold in the stably stratified layers where the flux is positive. We demonstrate the existence of a non-gradient contribution to the enthalpy flux, which is estimated to be important throughout the convective layer. A quantitative analysis of downflows indicates a transition from a tree-like structure where smaller downdrafts merge into larger ones in the upper parts to a structure in the deeper parts where a height-independent number of strong downdrafts persist. This change of flow topology occurs when a substantial subadiabatic layer is present in the lower part of the CZ.
Range-Wide and Regional Patterns of Population Structure and Genetic Diversity in the Gopher Tortoise
Authors: Gaillard D. , Ennen J.R. , Kreiser B.R. , Qualls C.P. , Sweat S.C. , Birkhead R. , Tuberville T.D. , Aresco M. , McCoy E.D. , Mushinsky H.R. , Hentges T.W. 
Published: August 2017

AbstractThe gopher tortoise (Gopherus polyphemus) has experienced dramatic population declines throughout its distribution in the southeastern United States and is federally listed as threatened in the area west of the Tombigbee and Mobile rivers. While there is molecular support for recognizing the listed portion of the range as genetically distinct, other research has suggested that additional population structure exists at both range-wide and regional scales. In this study, we sought to comprehensively define genetic population structure at both spatial scales by doubling the data available in terms of the number of sampling sites, individuals, and microsatellite loci compared to previously published work. We also compared patterns of genetic diversity, gene flow, and demographic history across the range. We collected 933 individuals from 47 sampling sites across the range and genotyped them for 20 microsatellite loci. Our range-wide analyses supported the recognition of five genetic groups (or regions) delineated by the Tombigbee and Mobile rivers, Apalachicola and Chattahoochee rivers, and the transitional areas between several physiographic province sections of the Coastal Plains (i.e., Eastern Gulf, Sea Island, and Floridian). We found genetic admixture at sampling sites along the boundaries of these genetically defined groups. We detected some degree of additional genetic structure within each of the five regions. Notably, within the range listed as threatened under the Endangered Species Act, we found some support for two additional genetic groups loosely delineated by the Pascagoula and Chickasawhay rivers, and we detected four more genetic groups within the Florida region that seemed to reflect the influence of the local physiography. Additionally, our range-wide analysis found the periphery of the range had lower levels of genetic diversity relative to the core. We suggest that the five main genetic groups delineated in our study warrant recognition as management units in terms of conservation planning. Intraregional population structure also points to the potential importance of other barriers to gene flow at finer spatial scales, although additional work is needed to better delineate these genetic groups.
Comparison of Body Composition and Fatty Acid Profiles between Wild and Cultured Rio Grande Silvery Minnows
Authors: Powell Madison S. , Hardy Ronald W. , Hutson Alison M. , Toya Louie A. , Tave Douglas 
Published: August 2017

AbstractFederally endangered Rio Grande Silvery Minnows (RGSM; Hybognathus amarus) were raised in one of three culture regimes: intensively, with only a hatchery diet; semi-intensively with access to natural food and hatchery diet supplementation; and with only natural food available at the Los Lunas Silvery Minnow Refugium (Los Lunas, New Mexico), a naturalized conservation refugium designed to mimic the natural environment of the RGSM in the Rio Grande. The project compared each culture regime and assessed differences and similarities in lipid and fatty acid content between feeding an artificial diet and consumption of natural food items in this species. After 117 d, whole-body lipid levels and fatty acid profiles were measured in each group and compared with values for wild RGSM. Fish fed the hatchery diet exclusively or as supplementary feed had significantly higher percent lipid (15.5% ± 0.5% and 10.6% ± 0.1%, respectively) than fish raised without access to the diet. Both groups had significantly higher percent lipid than fish raised in the refugium or wild fish (8.3% ± 0.1% and 7.8% ± 0.2%, respectively). Condition factor differed among groups and was highest in fish fed the hatchery diet (1.00) followed by fish supplemented with the hatchery diet (0.93), refugium fish (0.91), and wild fish (0.90). In this respect, refugium fish appeared more similar to wild fish than fish fed the hatchery diet or offered the diet as a supplement. Comparison of fatty acid profiles among groups showed marked differences among wild fish, refugium fish, and those fed the hatchery diet, either exclusively or as supplementary feed. Total omega-3 fatty acids, expressed as percentage of total fatty acids, were highest in wild fish but similar among other groups. Total omega-6 fatty acids showed an opposite trend, with five to nine times higher percentages of linoleic acid observed among fish from the three culture regimes compared with wild fish. Significant differences in lipid content and fatty acid composition between wild RGSM and cultured silvery minnows reflected their respective diets and culture regimes. Given similarities in fat content and condition factor with wild RGSM, we conclude that fish in the refugium do not require supplemental feeding with an artificial diet for this type of naturalized conservation management. Results from this study show that RGSM readily forage on natural food items present and also artificial feed when available, indicating dietary plasticity, which is advantageous for fish culture and future recovery.
Lead Poisoning in Bald Eagles Admitted to Wildlife Rehabilitation Facilities in Iowa, 2004–2014
Authors: Yaw Taylor , Neumann Kay , Bernard Linette , Cancilla Jodeane , Evans Terese , Martin-Schwarze Adam , Zaffarano Bianca 
Published: August 2017

Abstract
Eleven years (2004–2014) of bald eagle Haliaeetus leucocephalus data from four independent, state and federally permitted wildlife rehabilitators in Iowa were assessed for the prevalence of elevated lead levels in blood or tissue samples. The relationship between blood lead concentrations and recorded information (age, season, radiographs, and clinical outcome) was investigated. Adult birds had higher blood lead concentrations than immature and juvenile birds. Highest blood lead levels were found during October–January. Bald eagles with positive radiographs for metallic opacities in the digestive tract had higher blood and tissue lead concentrations than those with negative results or those on which no radiograph was performed. Metallic opacities were identified through necropsy. Bald eagles with elevated levels of lead were associated with poor clinical outcomes, indicating that blood lead concentrations could be used as a predictor of clinical outcome.
Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation
Authors: Song Dae Jin , Miller Marina , Beppu Andrew , Rosenthal Peter , Das Sudipta , Karta Maya , Vuong Christine , Mehta Amit Kumar , Croft Michael , Broide David H. 
Published: August 2017

Abstract
Orosomucoid like 3 (ORMDL3), a gene localized to chromosome 17q21, has been linked in epidemiologic studies to childhood asthma and rhinovirus (RV) infections. As the single nucleotide polymorphisms linking ORMDL3 to asthma are associated with increased expression of ORMDL3, we have used hORMDL3zp3-Cre mice (which have universal increased expression of human ORMDL3) to determine whether infection of these transgenic mice with RV influences levels of airway inflammation or RV viral load. RV infection of hORMDL3zp3-Cre mice resulted in reduced RV viral load assessed by quantitative real-time PCR (lung and airway epithelium), as well as reduced airway inflammation (total bronchoalveolar lavage cells, neutrophils, macrophages, and lymphocytes) compared with RV-infected wild-type mice. Levels of the antiviral pathways including IFNs (IFN-α, IFN-β, IFN-λ) and RNAse L were significantly increased in the lungs of RV-infected hORMDL3zp3-Cre mice. Levels of the antiviral mouse oligoadenylate synthetase (mOas)1g pathway and RNAse L were upregulated in the lungs of unchallenged hORMDL3zp3-Cre mice. In addition, levels of mOas2, but not mOas1 (mOas1a, mOas1b, mOas1g), or mOas3 pathways were significantly more upregulated by IFNs (IFN-α, IFN-β, IFN-λ) in epithelial cells from hORMDL3zp3-Cre mice compared with RV-infected wild-type mouse epithelial cells. RNAse L–deficient mice infected with RV had increased RV viral load. Overall, these studies suggest that increased levels of ORMDL3 contribute to antiviral defense to RV infection in mice through pathways that may include IFNs (IFN-α, IFN-β, IFN-λ), OAS, and RNAse L.
Anti-Cancer Drug HMBA Acts as an Adjuvant during Intracellular Bacterial Infections by Inducing Type I IFN through STING
Authors: Gamage Akshamal Mihiranga , Lee Kok-Onn , Gan Yunn-Hwen 
Published: August 2017

Abstract
The anti-proliferative agent hexamethylene bisacetamide (HMBA) belongs to a class of hybrid bipolar compounds developed more than 30 y ago for their ability to induce terminal differentiation of transformed cells. Recently, HMBA has also been shown to trigger HIV transcription from latently infected cells, via a CDK9/HMBA inducible protein-1 dependent process. However, the effect of HMBA on the immune response has not been explored. We observed that pretreatment of human peripheral blood mononuclear cells with HMBA led to a markedly increased production of IL-12 and IFN-γ, but not of TNF-α, IL-6, and IL-8 upon subsequent infection with Burkholderia pseudomallei and Salmonella enterica. HMBA treatment was also associated with better intracellular bacterial control. HMBA significantly improved IL-12p70 production from CD14+ monocytes during infection partly via the induction of type I IFN in these cells, which primed an increased transcription of the p35 subunit of IL-12p70 during infection. HMBA also increased early type I IFN transcription in human monocytic and epithelial cell lines, but this was surprisingly independent of its previously reported effects on positive transcription elongation factor b and HMBA inducible protein-1. Instead, the effect of HMBA was downstream of a calcium influx, and required the pattern recognition receptor and adaptor STING but not cGAS. Our work therefore links the STING-IRF3 axis to enhanced IL-12 production and intracellular bacterial control in primary monocytes. This raises the possibility that HMBA or related small molecules may be explored as therapeutic adjuvants to improve disease outcomes during intracellular bacterial infections.
CXCR3 Signaling Is Required for Restricted Homing of Parenteral Tuberculosis Vaccine–Induced T Cells to Both the Lung Parenchyma and Airway
Authors: Jeyanathan Mangalakumari , Afkhami Sam , Khera Amandeep , Mandur Talveer , Damjanovic Daniela , Yao Yushi , Lai Rocky , Haddadi Siamak , Dvorkin-Gheva Anna , Jordana Manel , Kunkel Steven L. , Xing Zhou 
Published: August 2017

Abstract
Although most novel tuberculosis (TB) vaccines are designed for delivery via the muscle or skin for enhanced protection in the lung, it has remained poorly understood whether systemic vaccine-induced memory T cells can readily home to the lung mucosa prior to and shortly after pathogen exposure. We have investigated this issue by using a model of parenteral TB immunization and intravascular immunostaining. We find that systemically induced memory T cells are restricted to the blood vessels in the lung, unable to populate either the lung parenchymal tissue or the airway under homeostatic conditions. We further find that after pulmonary TB infection, it still takes many days before such T cells can enter the lung parenchymal tissue and airway. We have identified the acquisition of CXCR3 expression by circulating T cells to be critical for their entry to these lung mucosal compartments. Our findings offer new insights into mucosal T cell biology and have important implications in vaccine strategies against pulmonary TB and other intracellular infections in the lung.
Local content requirements and the impact on the South African renewable energy sector: A survey-based analysis
Authors: Ettmayr Christopher , Lloyd Hendrik 
Published: August 2017

Background: Economies aim to grow over time, which usually implies the need for increased energy availability. Governments can use their procurement of energy to increase benefits in their economies via certain policy tools. One such tool is local content requirements (LCRs), where the purchase of goods prescribes that a certain value has to be sourced locally. The argument for this tool is that spending is localised and manufacturing, as well as job creation, can be stimulated because industry will need to establish in the host economy. However, this practice is distortionary in effect and does not create a fair playing ground for global trade. Furthermore, if the local content definition is weak, or open to manipulation, the goals of such a policy may not be achieved at all.Aim: The objective of this study was to determine how LCRs would ultimately impact on the overall procurement programme.Setting: This study took place as South Africa commenced with large scale development of the renewable energy sector. This was largely achieved via the State run Renewable Energy Independent Power Producer Procurement Programme (REIPPPP).Method: This study utilised opinion-based surveys to look into the LCRs of South Africa’s REIPPPP and measure the impact of this policy on the renewable energy sector in general. The mixed method approach was utilised to analyse qualitative and quantitative data and this was then triangulated with an international peer group to arrive at certain conclusions. The Delphi Technique was then employed to achieve population consensus on the findings.Results and conclusion: It was found that, in order to implement a policy such as local content without any negative welfare effects, the host economy had to show certain pre-existing conditions. Because South Africa does not hold all supportive pre-conditions, the impact and effect of LCRs have not been optimal, and it has not been found to be a sustainable mechanism to continue using indefinitely. The pricing of renewable energy was also found to be higher due to local content and such pricing is passed on to the energy consumer. The welfare created for South Africa, which should be in a trade-off for the creation of jobs and manufacturing, is therefore diminished and coupled with unsustainability and potential manipulation of the system, the country does not seem to be benefitting as it should be from this specific application of a local content policy.
Gender Differences in Attending Physicians' Feedback to Residents: A Qualitative Analysis
Authors: Mueller Anna S. , Jenkins Tania M. , Osborne Melissa , Dayal Arjun , O'Connor Daniel M. , Arora Vineet M. 
Published: August 2017

ABSTRACTBackground Prior research has shown a gender gap in the evaluations of emergency medicine (EM) residents' competency on the Accreditation Council for Graduate Medical Education (ACGME) milestones, yet the practical implications of this are not fully understood.Objective To better understand the gender gap in evaluations, we examined qualitative differences in the feedback that male and female residents received from attending physicians.Methods This study used a longitudinal qualitative content analysis of narrative comments by attending physicians during real-time direct observation milestone evaluations of residents. Comments were collected over 2 years from 1 ACGME-accredited EM training program.Results In total, 1317 direct observation evaluations with comments from 67 faculty members were collected for 47 postgraduate year 3 EM residents. Analysis of the comments revealed that the ideal EM resident possesses many stereotypically masculine traits. Additionally, examination of a subset of the residents (those with 15 or more comments, n = 35) showed that when male residents struggled, they received consistent feedback from different attending physicians regarding aspects of their performance that needed work. In contrast, when female residents struggled, they received discordant feedback from different attending physicians, particularly regarding issues of autonomy and assertiveness.Conclusions Our study revealed qualitative differences in the kind of feedback that male and female EM residents received from attending physicians. The findings suggest that attending physicians should endeavor to provide male and female residents with consistent feedback and guard against gender bias in their perceptions of residents' capabilities.
High-risk Cutaneous Squamous Cell Carcinoma
Authors: Fitzgerald C , O'Neill James Paul 
Published: August 2017

ABSTRACTCutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer worldwide. Cutaneous squamous cell carcinoma can potentially be treated fully with minimal morbidity when detected early; however, certain subtypes of cSCC have been shown to confer a poorer prognosis for patients. In these high-risk tumors, increased incidence of recurrence, as well as metastasis to local lymph nodes and distant sites, is seen as a result of certain patient characteristics and pathological features. While guidelines regarding the management of high-risk cSCC have been produced, no clear consensus management or prognostic algorithms exist. In this review, we discuss current definitions of high-risk cSCC, recommendations regarding the management of cSCC, and current guidelines.How to cite this articleFitzgerald C, O'Neill JP. High-risk Cutaneous Squamous Cell Carcinoma. Int J Head Neck Surg 2017;8(2):37-44.