bluuebunny/crossref_metadata_2025_split huggingface dataset:
Future Changes in Floods and Water Availability across China: Linkage with Changing Climate and Uncertainties
Authors: Li Jianfeng , Chen Yongqin David , Zhang Lu , Zhang Qiang , Chiew Francis H. S. 
Published: March 2016

AbstractFuture changes in floods and water availability across China under representative concentration pathway 2.6 (RCP2.6) and RCP8.5 are studied by analyzing discharge simulations from the Inter-Sectoral Impact Model Intercomparison Project (ISI-MIP) with the consideration of uncertainties among global climate models (GCMs) and hydrologic models. Floods and water availability derived from ISI-MIP simulations are compared against observations. The uncertainties among models are quantified by model agreement. Only model agreement >50% is considered to generate reliable projections of floods and water availability and their relationships with climate change. The results show five major points. First, ISI-MIP simulations have acceptable ability in modeling floods and water availability. The spatial patterns of changes in floods and water availability highly depend on the outputs of GCMs. Uncertainties from GCMs/hydrologic models predominate the uncertainties in the wet/dry areas in eastern/northwestern China. Second, the magnitudes of floods throughout China increase during 2070–99 under RCP8.5 relative to those with the same return periods during 1971–2000. The increase rates of larger floods are higher than those of the smaller ones. Third, water availability decreases/increases in southern/northern China under RCP8.5, but changes negligibly under RCP2.6. Fourth, more severe floods in the future are driven by more intense precipitation extremes over China. The negligible change in mean precipitation and the increase in actual evapotranspiration reduce the water availability in southern China. Fifth, model agreements are higher in simulated floods than water availability because increasing precipitation extremes are more consistent among different GCM outputs compared to mean precipitation.
Comparison of CIBSE thermal comfort assessments with SAP overheating assessments and implications for designers
Authors: Bateson Ashley 
Published: March 2016

A comparison of the overheating risk assessment of a number of residential developments shows that designs can more easily pass the Part L overheating assessment using the SAP methodology compared to the CIBSE thermal comfort assessment using dynamic modelling. There is a risk, therefore, that residences are being designed and built without an appropriate evaluation of overheating risk, if only the standard building regulation assessment procedure is used. The Part L overheating assessment is relatively simplistic, thus potentially leading to inappropriate design decisions regarding building form, materials and ventilation strategies. Dynamic modelling, on the other hand, provides a more detailed assessment and prediction of overheating risk and should be more widely used to evaluate residential designs. This work shows that, without appropriate evaluation, overheating risk in residences could increasingly become a problem. Practical application: Residential overheating risk assessments using CIBSE comfort criteria show that risk of overheating can occur in a sample of proposed residential properties, despite passing heat gain compliance checks for building regulations. Therefore, overheating assessments using dynamic thermal modelling, implemented at the planning and design stages, can provide a more appropriate assessment of thermal discomfort than Building Regulation Part L1A (criterion 3) compliance checks alone.
Statutory Auditors’ Independence in India: An Empirical Analysis from the Stakeholders’ Interest Perspective
Authors: Roy Mitrendu Narayan , Saha Siddhartha Sankar 
Published: March 2016

Executive Summary A business projects its financial performance through its financial statements. An audited financial statement is considered to be genuine and dependable by the stakeholders of the business. Therefore, statutory auditors should be self-regulating so that they can perform their professional role without being influenced by the management. The current regulatory framework for statutory auditors defines independence requirement for a statutory auditor in a professional engagement, points out circumstances that may create threats to independence and also proposes some measures to safeguard the same. However, in recent corporate accounting scandals, company’s failure led to devastating cost to the stakeholders, and audit failure was identified to be one of the causes behind them. Following investigations also sensed possible impairment of statutory auditors’ independence in those scams. In this backdrop, based on the existing literature on this subject, this article identifies variables influencing positively or negatively statutory auditors’ independence in their professional engagement. Opinions of statutory auditors and select other groups of respondents were collected. Most of the respondent groups believe that statutory auditors fail to detect irregularities in financial books due to their lack of independence and professional scepticism as was observed in this study. Several legal case decisions also support this finding. A long association between a statutory auditor and a client is one of the major reasons behind statutory auditors’ lack of independence. Opinions of respondents supported by applicable legal case decisions also proved that lax disciplinary measures and inadequate inspection framework caused audit failures in many recent cases. This study also analyses a significant difference of opinion among respondent groups and identifies the groups having a similar line of thought for each variable. One-way analysis of variance (ANOVA) and Tukey’s honestly significant difference (HSD) test were conducted, respectively, for these purposes. The result shows that significant differences exist among the respondent groups for most of the variables. Moreover, corporate executives have shown a significant difference of opinion from professional accountants, especially on the issue of statutory auditors’ negligence. While corporate executives believe statutory auditors are negligent in their duty, professional accountants oppose their views. Applicable legal case decisions also support such findings. Investors have shown similar views in line with academicians and students.
Lived experiences of parents caring for a child with a life-limiting condition in Australia: A qualitative study
Authors: Collins Anna , Hennessy-Anderson Nicole , Hosking Sarah , Hynson Jenny , Remedios Cheryl , Thomas Kristina 
Published: March 2016

Background: Experiential studies in paediatric palliative care are needed to enable an ongoing international agenda which supports the development of responsive family supports. Aim: To provide an in-depth exploration of the prevalent lived experiences of parents who are currently providing care for a child with a life-limiting condition in Australia. Design: Cross-sectional, prospective, qualitative study guided by an advisory group and reported according to the consolidated criteria for reporting qualitative studies. Transcripts were subjected to a thematic analysis, underpinned by an interpretative phenomenological framework. Setting/participants: Purposively sampled parents ( n = 14) recruited from a statewide paediatric hospice who self-identified as a ‘primary caregiver’ for one or more children and/or adolescents (⩽18 years) with a life-limiting condition. Results: Four key themes represented the prevalent experiences of parents: (1) trapped inside the house, (2) the protector, (3) living with the shadow and (4) travelling a different pathway. They describe parents’ physical and social isolation, exclusion from the workforce, pervasive grief and associated impacts to their health and well-being. Limited professional and diminished social supports resulted in full ownership of care responsibility. Yet, parents embraced their role as ‘protector’, reporting acquired meaning and purpose. Conclusion: This study builds upon the growing body of evidence available in paediatric palliative care internationally. The key themes highlight the substantial demand for both physical and emotional support beyond what is currently offered and call for the implementation of carefully planned support services and other societal initiatives which seek to alleviate the broad health impacts to caregivers.
Risk factors for erectile dysfunction in patients with cardiovascular disease
Authors: Chaudhary Rakesh Kumar , Shamsi Bilal Haider , Chen Hui-ming , Tan Tan , Tang Kai-fa , Xing Jun-ping 
Published: March 2016

Objective To examine the relationship between risk factors for cardiac disease and erectile dysfunction (ED) in men from Xi’an, China. Methods Participants were patients with cardiovascular disease who visited the Cardiovascular Medicine Department of Xi’an Jiaotong University First Affiliated Hospital between September 2011 and March 2012. Two hundred and fifty patients were issued with questionnaires and underwent a physical examination and blood test.Risk factors for ED were identified using univariate and multivariate analyses. Results In total, 222 participants returned valid questionnaires (89% response rate), underwent a physical examination and blood test, and were included in the study. The most common cardiovascular diseases were hypertension ( n = 142; 64%), coronary heart disease ( n = 90; 41%) and angina pectoris ( n = 78; 35%). Most patients ( n = 144; 65%) had two or more cardiovascular diseases. Age, smoking, body mass index, total cholesterol level, hypertension and the ratio of total cholesterol to high-density lipoprotein cholesterol were significantly associated with ED. Domestic location, level of education, participation in physical activity, diabetes and drinking alcohol were not associated with ED. Conclusions Common risk factors for cardiovascular disease are associated with ED in patients with cardiovascular disease. This study furthers understanding of the risk factors for ED in Chinese patients with cardiovascular disease and paves the way for further research into the prevention of ED.
When does chronic migraine strike? A clinical comparison of migraine according to the headache days suffered per month
Authors: Torres-Ferrús M , Quintana M , Fernandez-Morales J , Alvarez-Sabin J , Pozo-Rosich P 
Published: March 2016

Introduction According to the IHCD-3β classification, chronic migraine (CM) is headache occurring on 15 or more days/month. Episodic migraine (EM) can be divided into low frequency (LFEM) and high frequency (HFEM) depending on the headache days suffered per month. Methods We performed a clinical comparison of migraine characteristics according to monthly headache days suffered. Patients were divided into three groups: LFEM (1–9 headache days/month), HFEM (10–14 headache days/month) and CM (≥15 headache days/month). Results The analysis included 1109 patients. Previously reported differences between EM and CM were replicated. However, there were three times more clinical differences between LFEM and HFEM than between HFEM and CM (15 vs. 6). A new model that takes 10 headache days as a cut-off value for CM would have a minimally higher predictive capacity (72.8%) and no statistical differences (71.8%) when comparing it to the current classification. Conclusions HFEM patients have few clinical differences compared with CM patients. This includes the poor outcomes regarding headache-related disability and impact on daily life. According to these findings, neurologists and headache specialists should consider that the emotional and functional impact in HFEM patients could be as disabling as in those with CM.
Evaluation of Bleeding Events Requiring Hospitalization in Patients With Atrial Fibrillation Receiving Dabigatran, Warfarin, or Antiplatelet Therapy
Authors: Riley Tanya R. , Gauthier-Lewis Mary L. , Sanchez Chelsea K. , Riley Treavor T. 
Published: March 2016

Objective: To determine the incidence and severity of bleeding events requiring hospitalization among patients with atrial fibrillation (AF) receiving anticoagulants (dabigatran or warfarin) or antiplatelet agents (eg, aspirin and clopidogrel). Methods: This was a single-center, retrospective cohort study involving 1494 patients with AF hospitalized from November 1, 2010, to November 1, 2011, with prior warfarin, dabigatran, or antiplatelet therapy. Results: Overall bleeding events in the dabigatran group compared to the warfarin group were 24% and 12%, respectively ( P = .004). Of these events, individually, there were no significant differences in major (56% vs 58%, P = .88), life-threatening (25% vs 36%, P = .38), or minor bleeding (44% vs 42%, P = .06). Gastrointestinal (GI) bleeding occurred more in the dabigatran group compared to the warfarin group ( P = .02). Intracranial bleeding occurred in 15% of patients in the warfarin group and did not occur at all in the dabigatran group. Warfarin patients had significantly more overall bleeding events compared to antiplatelet therapy ( P < .001), with an increasing trend seen in major bleeding ( P = .06). GI bleeding, however, favored the warfarin group over the antiplatelet group (48% vs 73%, P = .04). Conclusion: Anticoagulation with dabigatran was associated with an overall increased occurrence of bleeding requiring hospital admission compared to warfarin. GI bleeding was more prevalent with dabigatran and antiplatelets than with warfarin. There were more intracranial hemorrhages seen in the warfarin group.
Tolerability of toceranib phosphate (Palladia) when used in conjunction with other therapies in 35 cats with feline oral squamous cell carcinoma: 2009–2013
Authors: Olmsted Gina A , Farrelly John , Post Gerald S , Smith Jaclyn 
Published: March 2016

Objectives Squamous cell carcinoma (SCC) is the most common oral tumor in cats and typically carries a poor prognosis with current treatment options. The objective of this study was to evaluate the toxicity of toceranib phosphate (Palladia; Pfizer) in cats with oral SCC in combination with other treatment modalities. Methods In this study, 35 cats were retrospectively evaluated to determine toxicity when treated with toceranib in combination with other treatment modalities. Cats received toceranib at a median dose of 2.75 mg/kg (range 1.9–4.17 mg/kg) 3 days a week. Cats also underwent additional therapies, including surgical excision, radiation therapy, chemotherapy and/or use of non-steroidal anti-inflammatory drugs. Results Toxicity was seen in six cats, with five cases of grade 1 or 2 gastrointestinal (GI) toxicity and one grade 4 metabolic toxicity. Toceranib was discontinued in one cat and two cats received dose reductions. None of the cats required treatment delays or hospitalization due to toxicity. Median toceranib treatment duration was 77 days (range 7–741 days). Conclusions and relevance This study revealed that toceranib was well tolerated by the majority of cats, with five cases of low-grade GI toxicity and one case of metabolic toxicity. Given the favorable toxicity profile, future studies further evaluating the safety and efficacy of toceranib for cats with oral SCC should be considered.
Does Rapid Diffusion of HbA1c Testing Affect Amputation Rates?
Authors: Bekelis Kimon , Gottlieb Daniel , Newhall Karina , Faerber Adrienne , Goodney Phillip 
Published: March 2016

Background: The association of speed of diffusion of Hemoglobin A1C (hbA1c) testing with temporal changes in outcomes of primary importance to patients with diabetes, such as amputation, remains an issue of debate. We investigated these correlations. Methods: We performed a retrospective cohort study of diabetics, based on Medicare fee-for-service claims data from 2002 to 2012. We examined the association of the rate of diffusion of HbA1c testing with changes in amputation rates. Our unit of analysis was the hospital referral region (HRR), a definition of tertiary care markets defined in the Dartmouth Atlas of Health Care. Results: From the 11 096 270 diabetics followed in our study for a mean follow-up of 4.1 years, 106 340 (0.96%) underwent lower extremity amputations. The speed of diffusion of HbA1c testing had a moderate association with the speed of diffusion of lower extremity amputations, after adjusting for multiple factors including baseline regional amputation and testing rates (adjusted difference, −0.7%; 95% confidence interval, −1.0% to −0.3%). The risk-adjusted HRR-level speed of diffusion of testing demonstrated significant correlation with the risk-adjusted HRR-level diffusion of amputations ( r = .250, P < .001). Conclusions: We observed a moderate association of the speed of diffusion of HbA1c testing with the speed of diffusion of lower extremity amputations among Medicare patients with diabetes. Improvements in performance on quality metrics such as HbA1c testing may not immediately translate into tangible patient outcomes.
Improvements in impaired GABA and GAD65/67 production in the spinal dorsal horn contribute to exercise-induced hypoalgesia in a mouse model of neuropathic pain
Authors: Kami Katsuya , Taguchi, MS Satoru , Tajima Fumihiro , Senba Emiko 
Published: March 2016

Background Physical exercise effectively attenuates neuropathic pain, and multiple events including the inhibition of activated glial cells in the spinal dorsal horn, activation of the descending pain inhibitory system, and reductions in pro-inflammatory cytokines in injured peripheral nerves may contribute to exercise-induced hypoalgesia. Since fewer GABAergic hypoalgesic interneurons exist in the dorsal horn in neuropathic pain model animals, the recovery of impaired GABAergic inhibition in the dorsal horn may improve pain behavior. We herein determined whether the production of gamma-aminobutyric acid (GABA) and glutamic acid decarboxylase (GAD) in the dorsal horn is restored by treadmill running and contributes to exercise-induced hypoalgesia in neuropathic pain model mice. C57BL/6 J mice underwent partial sciatic nerve ligation (PSL). PSL-Runner mice ran on a treadmill at 7 m/min for 60 min/day, 5 days/week, from two days after PSL. Results Mechanical allodynia and heat hyperalgesia developed in PSL-Sedentary mice but were significantly attenuated in PSL-Runner mice. PSL markedly decreased GABA and GAD65/67 levels in neuropils in the ipsilateral dorsal horn, while treadmill running inhibited these reductions. GABA+ neuronal nuclei+ interneuron numbers in the ipsilateral dorsal horn were significantly decreased in PSL-Sedentary mice but not in PSL-Runner mice. Pain behavior thresholds positively correlated with GABA and GAD65/67 levels and GABAergic interneuron numbers in the ipsilateral dorsal horns of PSL-Sedentary and -Runner mice. Conclusions Treadmill running prevented PSL-induced reductions in GAD65/67 production, and, thus, GABA levels may be retained in interneurons and neuropils in the superficial dorsal horn. Therefore, improvements in impaired GABAergic inhibition may be involved in exercise-induced hypoalgesia.
One-time intrathecal triamcinolone acetonide application alters the redox potential in cerebrospinal fluid of progressive multiple sclerosis patients: a pilot study
Authors: Müller Thomas , Herrling Thomas , Lütge Sven , Lohse Lutz , Öhm Gabi , Jung Katinka 
Published: March 2016

Introduction: Cerebrospinal fluid analysis may provide insight into the interplay between chronic inflammation and response to treatment. Objectives: To demonstrate the impact of one intrathecal triamcinolone injection on the redox potential and on ascorbyl radical appearance in the cerebrospinal fluid of chronic progressive multiple sclerosis patients. Methods: A total of 16 patients received 40 mg triamcinolone. Electron-spin resonance spectroscopy measured the oxidation range after copper ion [Cu (II)] addition and ascorbyl-radical bioavailability. Results: There was an increase of Cu (II) ion absorption, which reflects an augmented content of reduced proteins. Ascorbyl radicals were present in contrast to healthy controls according to the literature. Conclusion: Intrathecal steroid application alters the redox potential in cerebrospinal fluid. Our findings support the beneficial role of steroids on oxidative stress generally demonstrated by ascorbyl radical appearance. Reactive oxygen species decline is necessary for an upregulated production of reduced proteins.
Risk factors for infectious readmissions following radical cystectomy: results from a prospective multicenter dataset
Authors: Hemal Sij , Krane Louis S. , Richards Kyle A. , Liss Michael , Kader A. Karim , Davis Ronald L. 
Published: March 2016

Introduction: Radical cystectomy (RC) is the gold standard treatment for muscle-invasive bladder cancer. This procedure has a high rate of perioperative complications, many of which are infectious in nature. The objective of our study was to evaluate demographic, intrinsic and extrinsic patient variables associated with developing readmission within 30 days due to infectious complications following RC. Methods: We acquired data available from the American College of Surgeons National Surgical Quality Improvement Program. We queried this dataset to identify all patients who underwent RC for muscle-invasive malignant disease (CPT 188.x) in 2012 based on CPT coding. Logistic regression analysis was used to investigate the relationship between preoperative variables and readmissions for infectious complications. Results: Of the 961 patients undergoing cystectomy for malignancy, 159 (17%) required readmission for any indications at a median of 16 days (interquartile range 13–22 days) postoperatively. We identified 71 of a total of 159 (45%) readmissions, which were due to infectious complications. Smoking was more prevalent in the patient population readmitted for an infectious complication compared with the patient population readmitted for a non-infectious complication (37% versus 25%; p = 0.03). Using logistic regression analysis smoking was associated with a significant risk for readmission due to an infectious cause (odds ratio 2.28, 95% confidence interval 1.82–2.97, p = 0.02). Readmission due to an infectious etiology was not associated with other perioperative factors including type of urinary diversion, sex, duration of operation, hypertension, or recent weight loss. Conclusion: Readmission following RC is a common occurrence and infectious complications drive readmission in almost half of the cases. Current smoking was the only independent risk factor for an infectious readmission. Counseling patients in smoking cessation prior to the procedure may provide an avenue for quality improvement to limit readmissions.
Factors Influencing Diffusion of Electronic Medical Records: A Case Study in Three Healthcare Institutions in Japan
Authors: Ochieng Otieno George , Hosoi Ryozo 
Published: March 2016

This study examines the effect of three factors: information technology (IT) skills of healthcare workers, present status of computerisation in their organisations, and workers' attitudes on the diffusion of electronic medical records (EMRs) in the healthcare environment. Data were obtained from a self-questionnaire distributed to 390 healthcare workers. The study finds that respondents need an expanded EMR capability to include decision support systems and reminder systems, and that diffusion of EMR is heavily influenced by attitudes of healthcare workers. However, targeted training of healthcare workers is needed to foster positive attitudes about EMR, and build confidence in the benefits of these systems.