bluuebunny/crossref_metadata_2025_split huggingface dataset:
Narrative Theory, 2006–2015: Some highlights with applications to Ian McEwan’sAtonement
Authors: Phelan James 
Published: August 2017

AbstractThis essay is a sequel to “Narrative theory, 1966–2006: A narrative,” Chapter 8 of the 2006 edition ofThe nature of narrative.Rather than attempting to be comprehensive, it highlights five particular developments in the field, each connected with issues discussed in the 2006 essay, and it illustrates the interpretive consequences of each development by considering its implications for reading Ian McEwan’sAtonement.The first two developments are related to ongoing “instabilities” I identified at the end of the 2006 essay: unnatural narratology and theories of fictionality. The next three developments are related to the three main approaches I discussed in 2006: within cognitive theory, work on theory of mind or mind-reading; within feminist theory, work on intersectionality; within rhetorical theory, work on the narrative communication model.
Locally produced xenin and the neurotensinergic system in pancreatic islet function and β-cell survival
Authors: Khan Dawood , Vasu Srividya , Moffett R. Charlotte , Gault Victor A. , Flatt Peter R. , Irwin Nigel 
Published: August 2017

AbstractModulation of neuropeptide receptors is important for pancreatic β-cell function. Here, islet distribution and effects of the neurotensin (NT) receptor modulators, xenin and NT, was examined. Xenin, but not NT, significantly improved glucose disposal and insulin secretion, in mice. However, both peptides stimulated insulin secretion from rodent β-cells at 5.6 mmglucose, with xenin having similar insulinotropic actions at 16.7 mmglucose. In contrast, NT inhibited glucose-induced insulin secretion. Similar observations were made in human 1.1B4 β-cells and isolated mouse islets. Interestingly, similar xenin levels were recorded in pancreatic and small intestinal tissue. Arginine and glucose stimulated xenin release from islets. Streptozotocin treatment decreased and hydrocortisone treatment increased β-cell mass in mice. Xenin co-localisation with glucagon was increased by streptozotocin, but unaltered in hydrocortisone mice. This corresponded to elevated plasma xenin levels in streptozotocin mice. In addition, co-localisation of xenin with insulin was increased by hydrocortisone, and decreased by streptozotocin. Furtherin vitroinvestigations revealed that xenin and NT protected β-cells against streptozotocin-induced cytotoxicity. Xenin augmented rodent and human β-cell proliferation, whereas NT displayed proliferative actions only in human β-cells. These data highlight the involvement of NT signalling pathways for the possible modulation of β-cell function.
Regulation of protein function by S-nitrosation and S-glutathionylation: processes and targets in cardiovascular pathophysiology
Authors: Belcastro Eugenia , Gaucher Caroline , Corti Alessandro , Leroy Pierre , Lartaud Isabelle , Pompella Alfonso 
Published: August 2017

AbstractDecades of chemical, biochemical and pathophysiological research have established the relevance of post-translational protein modifications induced by processes related to oxidative stress, with critical reflections on cellular signal transduction pathways. A great deal of the so-called ‘redox regulation’ of cell function is in fact mediated through reactions promoted by reactive oxygen and nitrogen species on more or less specific aminoacid residues in proteins, at various levels within the cell machinery. Modifications involving cysteine residues have received most attention, due to the critical roles they play in determining the structure/function correlates in proteins. The peculiar reactivity of these residues results in two major classes of modifications, with incorporation of NO moieties (S-nitrosation, leading to formation of proteinS-nitrosothiols) or binding of low molecular weight thiols (S-thionylation, i.e. in particularS-glutathionylation,S-cysteinylglycinylation andS-cysteinylation). A wide array of proteins have been thus analyzed in detail as far as their susceptibility to either modification or both, and the resulting functional changes have been described in a number of experimental settings. The present review aims to provide an update of available knowledge in the field, with a special focus on the respective (sometimes competing and antagonistic) roles played by proteinS-nitrosations andS-thionylations in biochemical and cellular processes specifically pertaining to pathogenesis of cardiovascular diseases.
Eremophilane-type sesquiterpenes from fungi and their medicinal potential
Authors: Yuyama Kamila Tomoko , Fortkamp Diana , Abraham Wolf-Rainer 
Published: August 2017

AbstractEremophilanes are sesquiterpenes with a rearranged carbon skeleton formed both by plants and fungi, however, almost no plant eremophilanes are found in fungi. These eremophilanes possess mainly phytotoxic, antimicrobial, anticancer and immunomodulatory properties and in this review fungal eremophilanes with bioactivities of potential medicinal applications are reviewed and discussed. A special focus is set on natural products bearing highly functionalized fatty acids at C-1 or C-3 position of the eremophilane backbone. Many of these fatty acids seem to contribute to the bioactivity of the metabolites enhancing the activity of the sesquiterpene moieties. Several approaches for optimization of these natural products for clinical needs and testing of the resulting derivatives are presented and discussed. The combination of identification of bioactive natural products with their subsequent improvement using a variety of genetical or chemical tools and the pharmacokinetic assessment of the products is presented here as a promising approach to new drugs.
Brain plasticity, cognitive functions and neural stem cells: a pivotal role for the brain-specific neural master gene |-SRGAP2–FAM72-|
Authors: Ho Nguyen Thi Thanh , Kutzner Arne , Heese Klaus 
Published: August 2017

AbstractDue to an aging society with an increased dementia-induced threat to higher cognitive functions, it has become imperative to understand the molecular and cellular events controlling the memory and learning processes in the brain. Here, we suggest that the novel master gene pair |-SRGAP2–FAM72-| (SLIT-ROBO Rho GTPase activating the protein 2, family with sequence similarity to 72) reveals a new dogma for the regulation of neural stem cell (NSC) gene expression and is a distinctive player in the control of human brain plasticity. Insight into the specific regulation of the brain-specific neural master gene |-SRGAP2–FAM72-| may essentially contribute to novel therapeutic approaches to restore or improve higher cognitive functions.
Triple solutions for a Dirichlet boundary value problem involving a perturbed discrete p(k)-Laplacian operator
Authors: Khaleghi Moghadam Mohsen , Henderson Johnny 
Published: August 2017

Abstract
Triple solutions are obtained for a discrete problem involving a nonlinearly perturbed one-dimensional p(k)-Laplacian operator and satisfying Dirichlet boundary conditions. The methods for existence rely on a Ricceri-local minimum theorem for differentiable functionals. Several examples are included to illustrate the main results.
OD-characterization of alternating groups Ap+d
Authors: Yang Yong , Liu Shitian , Zhang Zhanghua 
Published: August 2017

Abstract
Let An be an alternating group of degree n. Some authors have proved that A10, A147 and A189 cannot be OD-characterizable. On the other hand, others have shown that A16, A23+4, and A23+5 are OD-characterizable. We will prove that the alternating groups Ap+d except A10, are OD-characterizable, where p is a prime and d is a prime or equals to 4. This result generalizes other results.
Monomial codes seen as invariant subspaces
Authors: García-Planas María Isabel , Magret Maria Dolors , Um Laurence Emilie 
Published: August 2017

Abstract
It is well known that cyclic codes are very useful because of their applications, since they are not computationally expensive and encoding can be easily implemented. The relationship between cyclic codes and invariant subspaces is also well known. In this paper a generalization of this relationship is presented between monomial codes over a finite field 𝔽 and hyperinvariant subspaces of 𝔽n under an appropriate linear transformation. Using techniques of Linear Algebra it is possible to deduce certain properties for this particular type of codes, generalizing known results on cyclic codes.
Expert knowledge and data analysis for detecting advanced persistent threats
Authors: Moya Juan Ramón , DeCastro-García Noemí , Fernández-Díaz Ramón-Ángel , Tamargo Jorge Lorenzana 
Published: August 2017

Abstract
Critical Infrastructures in public administration would be compromised by Advanced Persistent Threats (APT) which today constitute one of the most sophisticated ways of stealing information. This paper presents an effective, learning based tool that uses inductive techniques to analyze the information provided by firewall log files in an IT infrastructure, and detect suspicious activity in order to mark it as a potential APT. The experiments have been accomplished mixing real and synthetic data traffic to represent different proportions of normal and anomalous activity.
Increased miR-25 expression in serum of gastric cancer patients is correlated with CA19-9 and acts as a potential diagnostic biomarker
Authors: Le Qin , Jianhua Niu , Mulati  , Yu Xi , Jiageng He 
Published: August 2017

Abstract

Objective
To evaluate miR-25 expression in serum of gastric cancer (GC) patients and whether it can be a potential biomarker for GC diagnosis.

Methods
Forty one pathology confirmed GC patients and 41 healthy controls were included in this study. 10 mL peripheral venous blood were collected from GC patients and healthy controls. miR-25 relative expression and CA19-9 level in serum of GC patients and healthy controls were measured by real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) and enzyme linked immunosorbent assay (ELISA), respectively. The diagnostic sensitivity, specificity and receiver operating characteristic (ROC) curve of serum miR-25 and CA19-9 were calculated by STATA11.0 software.

Results
The relative expression of miR-25 was 0.47±0.53 and 0.05±0.36 in serum of GC patients and healthy controls respectively with significant statistical difference (P<0.05). The serum level of CA19-9 for GC patients and healthy controls were 11.91±6.17 U/mL and 7.40±3.97 U/mL, indicating GC patients were much higher than those of healthy controls (P<0.05). The diagnostic sensitivity and specificity were 78.05% and 60.98% with the cut-off value of 0.32 for serum miR-25. Under this cut-off value, the area under the ROC curve was 0.75. For serum CA19-9, the diagnostic sensitivity and specificity were 70.73% and 56.10% with the cut-off value of 9.22 U/mL. Under this cut-off value, the area under the ROC curve was 0.73 with the 95% confidence interval of 0.62-0.84. Positive correlation was found between serum miR-25 relative expression and CA19-9 concentration of GC patients (r=0.75, P<0.05).

Conclusion
According to our present study, serum miR-25 was elevated in GC patients which may serve as a diagnostic biomarker for GC.
Tolerance and nutrients consumption of Chlorella vulgaris growing in mineral medium and real wastewater under laboratory conditions
Authors: María de Lourdes Franco Martínez , María Dolores Josefina Rodríguez Rosales , Cuauhtémoc Ulises Moreno Medina , Alfredo de Jesús Martínez Roldán 
Published: August 2017

AbstractMicroalgae have the potential of consuming high amounts of nitrogen and phosphorus from wastewater; thus, avoiding the risk of eutrophication of the water bodies. Nevertheless, ammonium can usually inhibit the growth of microalgae. Tolerance to ammonium is specific of each strain; so, the development of tertiary wastewater treatment proposals, employing microalgae, has as a first step the study of its tolerance to N-NH3. In this work, the tolerance of Chlorella vulgaris to N-NH3, using mineral medium, was studied. Afterward, C. vulgaris was used to remove nitrogen and phosphorus from a real wastewater. The maximal biomass concentration was reached at 66 ppm N-NH3 (0.49 gL-1) with the complete depletion of the ammonium and a phosphorus consumption of 2 mgPi L-1d-1in all the experiments. When C. vulgaris was grown in real wastewater, the final biomass concentration was 0.267 g L-1and the nutrients (N and P) were totally consumed after 3 days. According with these results, this strain of Chlorella has the potential for the removal of nitrogen and phosphorus from tertiary wastewater and the biomass produced in the process can be used for the production of high value products, such as pigments, proteins, carbohydrate or used for animal feed.
Perspectives for Network Analysis: Roman Roads, Barbarian Paths and Settlement Patterns in the Borderlands at the Limes Germanicus in the Main River Region
Authors: Volkmann Armin 
Published: August 2017

AbstractIn contrast to the neighboring Roman Empire, no centralized sites in the sense of transregionally significant settlements are definitively verifiable outside of the Limes Germanicus in the research area at the middle Main River. However, some fortified hill forts do exist. Starting in late antiquity, these sites were temporarily occupied in times of internal and external conflict. Hill forts in the Babaricum were, without exception, sited on spurs at the Main or its tributaries. The course of the Main River constituted the primary transport route for the Romans into the Babaricum, although clear evidence of ship or harbor facilities has yet to be discovered for this period. The well-known hierarchical settlement and road system in the Roman Empire is not apparent in the Babaricum although numerous sunken roads in multiple path networks were discernible. Precise dating of these features to the Roman Iron Age or Migration Period has not been possible due to heavy soil erosion in the vicinity. Particular stretches of this network of paths were only seasonally in use depending on weather conditions and soil moisture, and so it is not realistic to discuss roadways as usable year-round in the Babaricum as they are in the Roman Empire. Some of these paths were fortified, although the dating of these fortifications is not possible due to the continued use of some of these pathways into the Early Modern Period. Nearest neighbor settlement relationships are methodically analyzed in network connection diagrams with the use of Delaunay triangulation in this GIS-based study. Probable routes by land and river are calculated with lost cost path analysis on the basis of digital surface models and compared with the local archaeological record.
Engineering of superconductors and superconducting devices using artificial pinning sites
Authors: Wördenweber Roger 
Published: August 2017

Abstract
Vortex matter in superconducting films and devices is not only an interesting topic for basic research but plays a substantial role in the applications of superconductivity in general. We demonstrate, that in most electronic applications, magnetic flux penetrates the superconductor and affects the performance of superconducting devices. Therefore, vortex manipulation turns out to be a useful tool to avoid degradation of superconducting device properties. Moreover, it can also be used to analyze and understand novel and interesting physical properties and develop new concepts for superconductor applications. In this review, various concepts for vortex manipulation are sketched. For example, the use of micro- and nanopatterns (especially, antidots) for guiding and trapping of vortices in superconducting films and thin film devices is discussed and experimental evidence of their vortex guidance and vortex trapping by various arrangements of antidots is given. We demonstrate, that the vortex state of matter is very important in applications of superconductivity. A better understanding does not only lead to an improvement of the performance of superconductor components, such as reduced noise, better power handling capability, or improved reliability, it also promises deeper insight into the basic physics of vortices and vortex matter.
In situ monitoring metal-ligand exchange processes by optical spectroscopy and X-ray diffraction analysis: a review
Authors: Terraschke Huayna , Rothe Merrit , Lindenberg Patric 
Published: August 2017

Abstract
Knowledge about the mechanisms involved in the structural development of solid materials at the atomic level is essential for designing rational synthesis protocols for these compounds, which may be used to improve desired technical properties, such as light emission, conductivity, magnetism, porosity or particle size, and may allow the tailored design of solid materials to generate the aforementioned properties. Recent technological advancements have allowed the combination of synchrotron-based in situ X-ray diffraction (XRD) with in situ optical spectroscopy techniques, providing researchers with remarkable opportunities to directly investigate structural changes during synthesis reactions. Among the various available methods to measure optical properties, in situ luminescence, UV/Vis absorption, and light transmission spectroscopies are highlighted here, with in situ luminescence being subdivided into in situ luminescence analysis of coordination sensors (ILACS) and time-resolved laser fluorescence spectroscopy (TRLFS). This article consists of a review of 122 references exploring various aspects of in situ analyses, with particular emphasis on the use of XRD-combined techniques in the study of metal-ligand exchange processes during the formation, phase transitions and decomposition of solid materials, including complexes, coordination polymers, metal-organic frameworks, nanoparticles and polyoxo- or chalcogenide metallates. We will then conclude with an exploration of future trends in this exciting research field.
Computerized neurocognitive interventions in the context of the brain training controversy
Authors: García-Betances Rebeca Isabel , Cabrera-Umpiérrez María Fernanda , Arredondo María T. 
Published: August 2017

AbstractThis article presents, in the form of an analytic narrative review, a complete picture of the state-of-the-art, challenges, and perspectives in the field of information and communication technology (ICT)-based neurocognitive interventions for older adults. The narrative particularly focuses on applications aimed at mild cognitive impairment and similar age-related cognitive deficits, which are analyzed in the context of the brain training controversy. Clarifying considerations are provided about the nature and present extent of the brain training debate, regarding the possible influence it has on the support received by research and development initiatives dealing with innovative computerized neurocognitive interventions. It is recommended that, because of the preliminary nature of most data currently available in this area, further research initiatives must be supported in the quest for better effectiveness of computer-based interventions intended for age-related cognitive impairment. The conclusion suggests that advanced ICT-based tools, such as virtual and augmented reality technologies, are the most fitting platforms for applying nonpharmacological computerized neurocognitive interventions.
Mechanical performance of polyester pin-reinforced foam filled honeycomb sandwich panels
Authors: Jayaram R.S. , Nagarajan V.A. , Kumar K.P. Vinod 
Published: August 2017

Abstract
Honeycomb sandwich panels entice continuously enhanced attention due to its excellent mechanical properties and multi-functional applications. However, the principal problem of sandwich panels is failure by face/core debond. Novel lightweight sandwich panels with hybrid core made of honeycomb, foam and through-thickness pin was developed. Reinforcing polyester pins between faces and core is an effectual way to strengthen the core and enhance the interfacial strength between the face/core to improve the structural performance of sandwich panels. To provide feasibility for pin reinforcement, honeycomb core was pre-filled with foam. Mechanical properties enhancement due to polyester pinning were investigated experimentally under flatwise compression, edgewise compression and flexural test. The experimental investigations were carried out for both “foam filled honeycomb sandwich panels” (FHS) and “polyester pin-reinforced foam filled honeycomb sandwich panels” (PFHS). The results show that polyester pin reinforcement in foam filled honeycomb sandwich panel enhanced the flatwise, edgewise compression and flexural properties considerably. Moreover, increasing the pin diameter has a larger effect on the flexural rigidity of PFHS panels. PFHS panels have inconsequential increase in weight but appreciably improved their structural performance.
The semiotics of breast cancer: Signs, symptoms, and sales
Authors: Tredinnick-Rowe John 
Published: August 2017

Abstract
This paper analyses the immunological response of breast cancer patients through the lens of medical semiotics. From this perspective both psychological and physiological symptoms are treated as a set of transitive signs. The symptomatic journey of breast cancer patients was documented through an ethnographic engagement with a breast cancer charity. This journey consists of diagnosis, treatment and remission, where both the physical and psychological trauma maybe irreversible. Equally the genetic disposition of each patient and the variability of the treatment give rise to a plethora of possible immunological responses. The case study organization provided both therapeutic treatment but also sold oncology products to its patients, matching the products’ composition to the specific immunological responses caused by breast cancer treatment, e.g., brittle skins or hair loss, etc. This paper explores how the varied and transient nature of immunological semiosis is identified and commoditized into an economic process. This challenging social context is of interest from a semiotic stand point because it offers a singular paradigm to explain the evolution of signs and symptoms into sales.
Void of sign
Authors: Tanaka-Ishii Kumiko 
Published: August 2017

AbstractThis article examines the concept of void with the question of whether the concept forms a sign. A void in this article is defined as a spatio-temporal empty space existing in a representation. The aim of the analysis is to consider the hidden nature of signs, which cannot be highlighted only through an analysis of typical signs within social convention. As a semiotic tool to conduct the discussion, the notion of a zero sign of Lévi-Strauss is introduced. The article considers all possible zeros that can exist within the Saussurian sign model and introduces three cases: an omitted sign, an ambiguous signified, and an ambiguous sign. After examining the features of each kind, the concept of void is considered in these terms, with the conclusion that it belongs to the ambiguous sign case. Analysis of void with respect to the zero sign highlights the nature of signs as being reflexive, holistic and speculative. Because the signifier is barely delimited, it influences the surrounding sign systems, including the one existing at the meta-level. An ambiguous sign is deemed to allow for concept sharing among people even when the signifier and the signified remain ambiguous.