bluuebunny/crossref_metadata_2025_split huggingface dataset:
DRG payment for major pancreatic surgery: analysis of resource consumption and suggestions from a tertiary hospital in China
Authors: Hou Rui , Liu Xiaokun , Zhou Jingya , Zhang Taiping , Wang Weibin , Zhu Weiguo 
Published: September 2024

AimTo investigate the cost homogeneity within the Diagnosis-Related Group (DRG) “major operation of pancreas and liver, with general complications or comorbidities” (HB13), its cost-influencing factors, and to propose suggestions for better grouping efficacy.MethodsMedical and insurance settlement data of inpatients covered by the DRG payment system at the author’s institution were collected from March 15, 2022 to December 31, 2023. The cost homogeneity of group HB13 was assessed using the coefficient of variation (CV). Clinical factors that may have an impact on hospitalization cost for patients undergoing pancreatic surgery were identified through a semi-structured interview administered to the pancreatic surgeons in author’s department, their significance was analyzed using multiple linear regression, along with their impact on the cost of different service categories. A proposal to subdivide HB13 was made and evaluated by CV and t-test.ResultsThe CV of the HB13 group was 0.4. Robotic-assisted surgery and pancreaticoduodenectomy were two independent factors that significantly affected the total cost. Patients undergoing robotic-assisted surgery have an average increase of 41,873 CNY in total cost, primarily derived from operation fee. Patients undergoing pancreaticoduodenectomy have an average increase of 37,487 CNY in total cost, with significant increases across all service categories. HB13 was subdivided based on whether pancreaticoduodenectomy was performed. The newly formed groups exhibited lower CVs than the original HB13.ConclusionThe cost homogeneity of HB13 was lower than that of other DRG groups in author’s department. It is recommended to introduce a supplementary payment for patients requiring robotic-assisted surgery, to guarantee their access to this advanced technology. It is recommended to establish a new group with higher payment standard for patients undergoing pancreaticoduodenectomy. A tiered CV criterion for the evaluation of grouping efficacy is recommended to increase intra-group homogeneity, facilitating a better allocation of health insurance funds, and the prevention of unintended negative outcomes such as service cuts and cherry-picking.
Precision prevention in occupational health: a conceptual analysis and development of a unified understanding and an integrative framework
Authors: Mess Filip , Blaschke Simon , Gebhard Doris , Friedrich Julian 
Published: September 2024

IntroductionPrecision prevention implements highly precise, tailored health interventions for individuals by directly addressing personal and environmental determinants of health. However, precision prevention does not yet appear to be fully established in occupational health. There are numerous understandings and conceptual approaches, but these have not yet been systematically presented or synthesized. Therefore, this conceptual analysis aims to propose a unified understanding and develop an integrative conceptual framework for precision prevention in occupational health.MethodsFirstly, to systematically present definitions and frameworks of precision prevention in occupational health, six international databases were searched for studies published between January 2010 and January 2024 that used the term precision prevention or its synonyms in the context of occupational health. Secondly, a qualitative content analysis was conducted to analyze the existing definitions and propose a unified understanding. Thirdly, based on the identified frameworks, a multi-stage exploratory development process was applied to develop and propose an integrative conceptual framework for precision prevention in occupational health.ResultsAfter screening 3,681 articles, 154 publications were reviewed, wherein 29 definitions of precision prevention and 64 different frameworks were found, which can be summarized in eight higher-order categories. The qualitative content analysis revealed seven themes and illustrated many different wordings. The proposed unified understanding of precision prevention in occupational health takes up the identified themes. It includes, among other things, a contrast to a “one-size-fits-all approach” with a risk- and resource-oriented data collection and innovative data analytics with profiling to provide and improve tailored interventions. The developed and proposed integrative conceptual framework comprises three overarching stages: (1) data generation, (2) data management lifecycle and (3) interventions (development, implementation and adaptation).DiscussionAlthough there are already numerous studies on precision prevention in occupational health, this conceptual analysis offers, for the first time, a proposal for a unified understanding and an integrative conceptual framework. However, the proposed unified understanding and the developed integrative conceptual framework should only be seen as an initial proposal that should be critically discussed and further developed to expand and strengthen both research on precision prevention in occupational health and its practical application in the workplace.
Sustainable fresh strawberry consumption: environmental, genetically modified food, and climate concerns in Europe and North Africa
Authors: Zeneli Fjona , Ventura Vera , Frisio Dario Gianfranco 
Published: September 2024

Background and gap in the literatureSeasonal strawberries are a tasty fruit with many significant health and environmental benefits. Despite these attributes, the determinants influencing strawberry consumption remain underexplored. Few existing research studies are focused on conventional factors, such as taste, freshness, and price, leaving aside some critical, current dimensions, such as consumers’ environmental attitude, sustainability, genetically modified (GM) food knowledge, and climate change concerns. This article aims to explore the impact of the aforementioned factors on the purchasing behavior of strawberries among consumers.MethodologyA designed questionnaire for a final sample of 2,378 consumers from Italy, Germany, France, Spain, Turkey, and Morocco was used to collect data about sociodemographic attributes, strawberry purchasing habits, respondents’ level of knowledge on the topic of GM food, and climate change issue. The generalized ordinal logistic approach was performed deriving from the ordinal qualitative type of our two variables of interest (seasonal and non-seasonal strawberries purchase) and relaxing the assumption of parallel lines.Main resultsFrom the sociodemographic factors, the more educated individuals, living in urban areas and having higher income levels are more likely to purchase frequently seasonal strawberries, while older people buy less often non-seasonal strawberries. Individuals who are more aware of sustainability issues, exhibit sustainable behaviors, and have greater concerns about climate change are more likely to buy non-seasonal strawberries less frequently, which is the most important result of our analysis.ImplicationsThese results offer a comprehensive understanding of other drivers than the conventional ones related to seasonal and non-seasonal strawberry purchase patterns, giving significant insights for policymakers in formulating tailored interventions for other dimensions: promoting sustainable agricultural practices (following the seasonality of the fruit), increasing consumer awareness about the environmental implications of the non-seasonal fruit purchases, and shifting individual eating patterns toward more sustainable and healthy ones (fresh and seasonal fruit consumption).
Safety and efficacy of toll-like receptor agonists as therapeutic agents and vaccine adjuvants for infectious diseases in animals: a systematic review
Authors: Oboge Harriet , Riitho Victor , Nyamai Mutono , Omondi George P. , Lacasta Anna , Githaka Naftaly , Nene Vishvanath , Aboge Gabriel , Thumbi S. M. 
Published: September 2024

IntroductionStrengthening global health security relies on adequate protection against infectious diseases through vaccination and treatment. Toll-like receptor (TLR) agonists exhibit properties that can enhance immune responses, making them potential therapeutic agents or vaccine adjuvants.MethodsWe conducted an extensive systematic review to assess the efficacy of TLR agonists as therapeutic agents or vaccine adjuvants for infectious diseases and their safety profile in animals, excluding rodents and cold-blooded animals. We collected qualitative and available quantitative data on the efficacy and safety outcomes of TLR agonists and employed descriptive analysis to summarize the outcomes.ResultsAmong 653 screened studies, 51 met the inclusion criteria. In this review, 82% (42/51) of the studies used TLR agonists as adjuvants, while 18% (9/51) applied TLR agonist as therapeutic agents. The predominant TLR agonists utilized in animals against infectious diseases was CpG ODN, acting as a TLR9 agonist in mammals, and TLR21 agonists in chickens. In 90% (46/51) of the studies, TLR agonists were found effective in stimulating specific and robust humoral and cellular immune responses, thereby enhancing the efficacy of vaccines or therapeutics against infectious diseases in animals. Safety outcomes were assessed in 8% (4/51) of the studies, with one reporting adverse effects.DiscussionAlthough TLR agonists are efficacious in enhancing immune responses and the protective efficacy of vaccines or therapeutic agents against infectious diseases in animals, a thorough evaluation of their safety is imperative to in-form future clinical applications in animal studies.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=323122.
Bacteriophage P2-71: a promising therapeutic against multidrug-resistant Proteus mirabilis in urinary tract infections
Authors: Wu Ruihu , Dong Zhiyou , Liu Yunjiang , Xin Jialiang , Duan Yuxi , Zheng Haohong , Yang Yizhou , Fu Hualin , Zhong Zhijun , Liu Haifeng , Zhou Ziyao , Huang Yixin , Peng Guangneng 
Published: September 2024

BackgroundProteus mirabilis is a Gram-negative, rod-shaped bacterium widely found in natural environments. It is known for causing a range of severe illnesses in mammals, particularly urinary tract infections (UTIs). This study evaluates the therapeutic efficacy of phage P2-71 against Proteus mirabilis in vivo and in vitro environments.MethodsThe in vitro therapeutic potential of bacteriophage P2-71 was assessed through the ability of phage to kill Proteus mirabilis by using a plate counting assay, and biofilm inhibition and biofilm lysis assays using a microtitre plate method. Additionally, an in vivo UTI model in C57BL/6Jmice was developed via urethral inoculation of the bacterium. Phage therapy was administered through urethral injection over a period of 5 days. Therapeutic outcomes were measured by analyzing bacterial load, phage titer, inflammatory markers, and histopathological changes in the urine, urogenital tissues, and spleen.ResultsIn vitro, bacteriophage P2-71 achieved significant reductions in P. mirabilis concentrations, with log reductions of 1.537 and 0.7009 CFU/mL in laboratory and urine environments, respectively (p &lt; 0.001). The phage also decreased biofilm formation by 34–49% and lysed 15–25% of mature biofilms at various multiplicities of infection (MOIs) (p &lt; 0.001). In vivo, phage treatment significantly lowered bacterial concentrations in the urine on Days 1 and 3 (p &lt; 0.0001), achieving a maximum reduction of 4.602 log₁₀ CFU/mL; however, its effectiveness diminished by Day 5 (p &gt; 0.05). Concurrently, phage titers decreased over time. Importantly, phage treatment notably reduced bacterial load in the bladder, kidneys, and spleen (p &lt; 0.001). Inflammatory markers such as IL-6, IL-1β, and TNF-α were significantly lower in the treatment group, especially in the bladder (p &lt; 0.0001), indicating an effective reduction in inflammation. Histopathological analysis showed significant mitigation of tissue damage.ConclusionThe results demonstrated that bacteriophage P2-71 is a promising alternative therapy for UTIs caused by MDR Proteus mirabilis. This bacteriophage therapy offers a viable strategy for managing infections where traditional antimicrobials fail, highlighting its potential in clinical applications.
Pharmacokinetics and thermal anti-nociceptive effects of oral morphine in horses
Authors: Knych Heather K. , Steinmetz Stacy J. , Traynham Megan L. , McKemie Daniel S. , Kass Philip H. 
Published: September 2024

IntroductionMorphine is an effective analgesic in horses, however, IV administration at therapeutic doses has been shown to produce dose-dependent neuroexcitation and unwanted gastrointestinal effects. The analgesic effects of morphine have, at least in part, been attributed to the morphine-6-glucuronide (M6G) metabolite. Oral administration to horses results in comparable M6G concentrations to that achieved following IV administration of a therapeutic dose without the adverse effects. The anti-nociceptive effects have not yet been reported. In the current study the thermal anti-nociceptive effects of single and multiple oral doses of morphine were assessed.MethodsSix horses received a single 0.2 mg/kg IV dose of morphine and multiple oral doses of 0.8 mg/kg morphine every 12 h for 4.5 days. Blood samples were collected throughout administration, morphine, and metabolite concentrations determined and pharmacokinetic analysis performed. Drug related behavior and physiologic responses were recorded. Response to noxious stimuli was evaluated by determining thermal threshold latency in response to the application of heat.ResultsThe maximum concentrations of M6G were higher following oral administration compared to IV and the combined morphine and M6G concentrations exceeded that of IV administration starting at 2 h. Oral administration of 0.8 mg/kg morphine provided and maintained comparable anti-nociception effects to IV morphine with less adverse effects, following single and multiple doses. Morphine was well tolerated following oral administration with less excitation and minimal effects on gastrointestinal borborygmi scores compared to IV administration.DiscussionResults of the current study warrant further investigation of the anti-nociceptive effects of oral morphine administration to horses.
Meningkatkan kemampuan pemecahan masalah matematis siswa: Pengembangan modul pembelajaran berbasis studi etnomatematika pada budidaya tanaman hidroponik
Authors: Nisa Mir Atun , Kumala Fitria Zana 
Published: September 2024

This study aims to develop an ethnomathematical study-based learning module on hydroponic plant cultivation to improve the mathematical problem-solving ability of class VII junior high school students on social arithmetic material that meets the criteria of validity and effectiveness. This research method is research and development with the ADDIE model (analysis, design, development, implementation, evaluation). Data collection instruments include interviews, validation sheets, questionnaires, and pre-test and post-test questions. The data were analyzed using qualitative and quantitative data analysis techniques. The results showed that ethnomathematics research-based learning modules were considered effective and feasible, with a percentage of 90% results verified by material and ethnomathematics experts, 96% by media experts, 90% teacher assessments, and a pass rate of group examination assessments of 87.3%, and a pass rate of on-site examination evaluations of 88.61%. The modules developed are also claimed to be effective in improving students' mathematical solving skills, with the experimental class having an average N-gain score of 0.78 in the "very high" category, better than the control class with an average N-gain score of 0.32 in the "medium" category. Both data were tested using a two-sample t-test and obtained 0.00 results less than 0.05 then H0 was rejected and H1 was accepted.
Tanques de geomembrana com sistema de recirculação de água como alternativa para o cultivo de pintados
Authors: Diemer Odair , Signor Altevir 
Published: September 2024

O presente estudo teve como objetivo analisar o desempenho zootécnico de pintados criados em tanques elevados de geoembrana com sistema de recirculação de água. Para tanto, foram distribuidos aleatoriamente 360 peixes em três tanques de geomembrana, com capacidade de 10 m3 de água cada, sendo 120 peixes por tanque. O arraçoamento foi realizado duas vezes ao dia, até a saciedade aparente, às 07h00min e 19h00min com ração extrusada, contendo 28% de proteína bruta, durante um período de 210 dias e mensalmente foram realizadas biometrias para analisar o peso médio, comprimento médio, ganho de peso e conversão alimentar. A qualidade da água durante o periodo experimental não apresentou níveis críticos para a produção dos peixes e no final dos 210 dias de criação os peixes apresentaram peso final médio de 421,67g, comprimento final médio de 36,78cm, ganho de peso final médio de 411,00g e conversão alimentar final média de 1,81, não havendo diferença significativa (p>0,05) entre os tanques. Os resultados indicam que o pintado tem potencial para ser criado em tanques elevados de geomembrana com sistema de recirculação de água.
Perfil epidemiológico da Chikungunya em município do semiárido baiano, no cenário pandêmico por COVID-19
Authors: Pereira Lorena Caires , Ribeiro Patrícia dos Santos , Faria Raimundo Nonato 
Published: September 2024

O presente artigo objetiva definir o perfil epidemiológico da Chikungunya nos anos de 2019/2020/2021 - no município de Guanambi-BA. Métodos: Trata-se de um estudo transversal, descritivo e retrospectivo, com abordagem quantitativa, a partir de buscas realizadas nas plataformas DATASUS, informações obtidas nas bases de dados de vigilância epidemiológica do município de Guanambi, SESAB e Instituto Nacional de Meteorologia. Os dados utilizados no trabalho são de domínio público. Dessa forma, não houve necessidade de submissão ao Comitê de Ética em Pesquisa com seres humanos, e verificação de Termo de Consentimento Livre e Esclarecido. Resultados: Houve 1.239 casos notificados entre 2029 - 2021 na cidade de Guanambi, no segundo semestre de 2020 as infecções arbovírus diminuiram substancialmente. No entanto, acredita-se que essa queda esteja relacionada a subnotificação em decorrência da pandemia por COVID-19 vigente. Conclusão: Portanto, conclui-se que durante a pandemia, ocorreu – de fato- uma sobreposição da epidemia do CHIKV.
Características radiológicas de pacientes com Picnodisostose: uma revisão de 21 casos do nordeste brasileiro
Authors: Bastos Filho Francisco André Gomes , Cunha Livia Costa , Albuquerque Filho Luciano Barroso de , Sampaio Maria Luiza Viana , Maia Filho Josevaldo Monteiro , Luz Kelnner Portela , Ribeiro Erlane Marques 
Published: September 2024

A Picnodisostose é uma doença de herança autossômica recessiva rara e com um fenótipo de fácil reconhecimento clínico devido a alterações faciais, baixa estatura desproporcionada, alterações esqueléticas, osteopetrose e predisposição a fraturas. Considerando que o diagnóstico molecular é de difícil acesso pelos pacientes de serviço público de saúde, objetiva-se obter o reconhecimento das suas alterações radiológicas,o que facilita o diagnóstico precoce dessa condição. Foi realizado um estudo quantitativo, transversal, retrospectivo e descritivo de pacientes com picnodisostose assistidos em um hospital público, terciário, de referência para doenças genéticas da Secretaria de Saúde do Estado do Ceará no período de 1995 a 2019, incluindo aqueles entre 0 e 18 anos que tinham radiografia simples de esqueleto nos prontuários médicos .Os dados do estudo foram agrupados utilizando-se Microsoft Excel para Office 365, a análise estatística foi realizada com SSPS 17.0, e variáveis categóricas foram resumidas usando frequência e percentagem. Foram analisados 21 casos, sendo 10 do sexo masculino e 11 feminino. O achado radiológico mais frequente foi o ângulo mandibular obtuso, observado em 19 casos (90%). Em 18 pacientes (86%), foi encontrada proeminência do osso frontal. Nas extremidades, a acrosteólise das falanges das mãos esteve presente em 18 pacientes (86%), sendo 9 também portadores de acrosteólise nas falanges dos pés. Em 17 casos (81%), evidenciou-se alargamento das suturas do crânio, e em 17 (81%), foi constatado aumento geral da densidade óssea. Esses achados permitem concluir uma caracterização melhor do fenótipo radiológico da Picnodisostose.
Métodos de conservação da fertilidade para pacientes oncológicos: uma revisão integrativa
Authors: Milagre Cláudia Cristine Silva , Dahe Dahra Guimarães , Ribeiro Fabrícia Gabrielle Gonçalo , Junqueira Layla Felix , Silva Mariah Oliveira e 
Published: September 2024

Introdução: De acordo com dados descritos em estudo, anualmente, 650 mil pacientes do sexo feminino evoluem com câncer invasivo e 8% delas possuem idade menor que 40 anos, cerca de uma a cada 52 mulheres deverão ter câncer antes dos 39 anos, e a cada ano mais mulheres jovens são acometidas com câncer. Em contrapartida, o percentual de cura aumenta gradativamente, cerca de 0,6% ao ano. Tendo em vista o avanço dos tratamentos oncológicos nas últimas décadas, a expectativa de sobrevida após um diagnóstico neoplásico, tende a ser maior, tornando-se necessária a preocupação com a melhoria da qualidade de vida dessas pacientes, após a remissão da doença, incluindo a preservação de sua fertilidade. Objetivo: Identificar, sistematizar e orientar sobre os métodos de conservação da fertilidade disponíveis atualmente. Método: Trata-se de uma revisão de literatura realizada nas bases de dados Scientific Electronic Library Online (Scielo); Biblioteca Virtual em Saúde (BVS); Sciencie direct. Resultados: Foram identificados 400 artigos, dos quais, após critérios de inclusão e exclusão, foram selecionados 37. Conclusão: É relevante discutir sobre os tipos de métodos de preservação da fertilidade que a paciente pode se submeter, sua disponibilidade e suas chances de sucesso e, deixar claro, que eles não podem interferir no seu desfecho oncológico. Além disso, devem ser questionados idade, paridade e comorbidades, que serão indispensáveis para a definição de tratamento e conduta corretos.
ANALISIS STRATEGI INFLUENCER MARKETING PADA INSTAGRAM STUDIO DAPUR TAHUN 2024
Authors: Yudhistira Akhmad Kurniawan  , Widya Sastika  
Published: September 2024

Business competition has significantly increased over time as various companies introduce innovative flagship products. Consumers are more likely to choose well-known brands when selecting products. Therefore, companies must find effective marketing strategies to ensure that consumers recognize the products or services offered. One factor that can influence a company's or enterprise's recognition is improving brand awareness. To increase brand awareness, one of the most appropriate strategies is using influencers as part of promotions, or influencer marketing. Influencer marketing involves promoting products through influencers to their followers. The purpose of this research is to understand the stages and implementation of influencer marketing at Studio Dapur. The method used in this research is descriptive qualitative, consisting of participatory observation, interviews, documentation, and triangulation. The results of this study conclude that the implementation of the influencer marketing strategy on Studio Dapur's Instagram has yielded positive results, particularly in terms of engagement rate, with an average achievement of 1-5% from the four influencers used. These results indicate strong performance and have a direct impact on increasing brand awareness.