bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study
Authors: de la Cruz-Merino Luis , Di Guardo Lorenza , Grob Jean-Jacques , Venosa Alfredo , Larkin James , McArthur Grant A. , Ribas Antoni , Ascierto Paolo A. , Evans Jeffrey T. R. , Gomez-Escobar Antonio , Barteselli Giulio , Eng Susan , Hsu Jessie J. , Uyei Anne , Dréno Brigitte 
Published: June 2017

Abstract
Background
Serous chorioretinopathy has been associated with MEK inhibitors, including cobimetinib. We describe the clinical features of serous retinopathy observed with cobimetinib in patients with BRAFV600-mutated melanoma treated in the Phase III coBRIM study.

Methods
In the coBRIM study, 493 patients were treated in two randomly assigned treatment groups: cobimetinib and vemurafenib (n = 247) or vemurafenib (n = 246). All patients underwent prospective ophthalmic examinations at screening, at regular intervals during the study, and whenever ocular symptoms developed. Patients with serous retinopathy were identified in the study database using a group of relevant and synonymous adverse event terms.

Results
Eighty-six serous retinopathy events were reported in 70 patients (79 events in 63 cobimetinib and vemurafenib-treated patients vs seven events in seven vemurafenib-treated patients). Most patients with serous retinopathy identified by ophthalmic examination had no symptoms or had mild symptoms, among them reduced visual acuity, blurred vision, dyschromatopsia, and photophobia. Serous retinopathy usually occurred early during cobimetinib and vemurafenib treatment; median time to onset was 1.0 month. Most events were managed by observation and continuation of cobimetinib without dose modification and resolved or were resolving by the data cutoff date (19 Sept 2014).

Conclusions
Cobimetinib treatment was associated with serous retinopathy in patients with BRAFV600-mutated melanoma. Retinopathy was generally asymptomatic or mild. Periodic ophthalmologic evaluations at regular intervals and at the manifestation of any visual disturbance are recommended to facilitate early detection and resolution of serous retinopathy while patients are taking cobimetinib.
Trial Registration Clinicaltrials.gov (NCT01689519). First received: September 18, 2012
Silk fibroin/hydroxyapatite composite hydrogel induced by gamma-ray irradiation for bone tissue engineering
Authors: Kim Min Hee , Kim Beom Su , Lee Jun , Cho Donghwan , Kwon Oh Hyeong , Park Won Ho 
Published: June 2017

Abstract

Background
In this study, silk fibroin (SF) composite hydrogels containing hydroxyapatite (HAP) nanoparticles (NPs) for bone tissue engineering were fabricated using gamma-ray (γ-ray) irradiation treatment. During the irradiation, the HAP dispersed SF solution was changed to the chemically crosslinked SF hydrogel.

Methods
Distribution of HAP NPs in the SF hydrogel was examined by SEM imagery and energy dispersive X-ray spectrophotometry, and the crystalline structure of SF composite hydrogels was also confirmed by X-ray diffractometry. An optimum preparation condition of the SF/HAP composite hydrogels was determined with various HAP contents. For evaluation of the osteogenic differentiation of human mesenchymal stem cells (hMSCs), alkaline phosphatase activity (ALP), HAP nucleation in SBF and in vitro calcium accumulation were measured.

Results
The results revealed that compared with the pure SF hydrogels, the SF/HAP composite hydrogels improved osteogenic differentiation.

Conclusion
This paper demonstrates the great potential of the SF/HAP composite hydrogels in terms of the production of the bone tissue engineering scaffolds for which osteogenesis is required.
Cellular functions of WASP family proteins at a glance
Authors: Alekhina Olga , Burstein Ezra , Billadeau Daniel D. 
Published: June 2017

ABSTRACT
Proteins of the Wiskott–Aldrich syndrome protein (WASP) family function as nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives the generation of branched actin filaments. Arp2/3-generated actin regulates diverse cellular processes, including the formation of lamellipodia and filopodia, endocytosis and/or phagocytosis at the plasma membrane, and the generation of cargo-laden vesicles from organelles including the Golgi, endoplasmic reticulum (ER) and the endo-lysosomal network. Recent studies have also identified roles for WASP family members in promoting actin dynamics at the centrosome, influencing nuclear shape and membrane remodeling events leading to the generation of autophagosomes. Interestingly, several WASP family members have also been observed in the nucleus where they directly influence gene expression by serving as molecular platforms for the assembly of epigenetic and transcriptional machinery. In this Cell Science at a Glance article and accompanying poster, we provide an update on the subcellular roles of WHAMM, JMY and WASH (also known as WASHC1), as well as their mechanisms of regulation and emerging functions within the cell.
Stress-specific p38 MAPK activation is sufficient to drive EGFR endocytosis but not its nuclear translocation
Authors: Tomas Alejandra , Jones Sylwia , Vaughan Simon O. , Hochhauser Daniel , Futter Clare E. 
Published: June 2017

ABSTRACT
EGF receptor (EGFR) endocytosis is induced by stress in a manner dependent on the p38 MAPK family. Ligand and stresses such as X-rays, reportedly promote nuclear trafficking of endocytosed EGFR for regulation of gene transcription and DNA repair. We fail to detect EGFR endocytosis or nuclear transport following X-ray treatment of HeLa or head and neck cancer cells, despite extensive DNA damage induction. Apparent nuclear staining with EGFR extracellular domain antibody remained present despite reduced/absent EGFR expression, and so did not represent nuclear EGFR. UVB and UVC, but not X-ray or UVA, treatment induced p38 activation and EGFR endocytosis, although all of these stresses induced DNA damage, indicating that DNA damage alone is not sufficient to induce EGFR endocytosis. Increased reactive oxygen species (ROS) levels following UVB treatment, compared to that seen with X-rays, do not alone explain differences in p38 activation. UVB, like UVC, induced EGFR accumulation predominantly in perinuclear endosomes, rather than in the nucleus. Our morphological techniques identifying major changes in receptor distribution do not exclude the possibility that small but biologically relevant amounts of EGFR enter the nucleus. This study highlights the importance and limitations of morphological analyses of receptor distribution in understanding signaling outcome.
Communication in palliative care: the applicability of the SAGE and THYME model in Singapore
Authors: Martin Ang Seng Hock , Costello John , Griffiths Jane 
Published: June 2017

Background: Majority of the progress and development in palliative care in the last decade has been improvements in physical aspects of treatment, namely pain and symptom management. Psychosocial aspects of care have improved, although not enough to meet the needs of many patients and family members. This is evident in many parts of the world and notably in Singapore, where palliative care is seen as an emerging medical and nursing specialty. Aim: To discuss the implementation of the SAGE and THYME communication model in a palliative care context. The article examines the use of the model and how its implementation can improve communication between patients and nurses. The model works by reviewing contemporary developments made in relation to improving communication in palliative care. These include, highlighting the importance of meeting individual needs, therapeutic relationship building, and advanced communication training within a Singaporean context. Results: The implementation of the SAGE and THYME model can be a useful way of enabling nurses to improve and maintain effective communication in a medically dominated health care system. The challenges and constraints in educating and training nurses with limited skills in palliative care, forms part of the review, including the cultural and attitude constraints specific to Singaporean palliative care.
Nutrition and osteoporosis prevention for the orthopaedic surgeon
Authors: Higgs Jennette , Derbyshire Emma , Styles Kathryn 
Published: June 2017

Osteoporosis is a prevalent and debilitating condition with no signs of subsiding. Rising numbers of people consuming nutrient-poor diets coupled with ageing populations and sedentary lifestyles appear to be the main drivers behind this. While the nutrients calcium and vitamin D have received most attention, there is growing evidence that wholefoods and other micronutrients have roles to play in primary and potentially secondary osteoporosis prevention. Until recently, calcium and vitamin D were regarded as the main nutrients essential to bone health but now there are emerging roles for iron, copper and selenium, among others. Fruit and vegetables are still not being eaten in adequate amounts and yet contain micronutrients and phytochemicals useful for bone remodelling (bone formation and resorption) and are essential for reducing inflammation and oxidative stress. There is emerging evidence that dried fruits, such as prunes, provide significant amounts of vitamin K, manganese, boron, copper and potassium which could help to support bone health. Just 50 g of prunes daily have been found to reduce bone resorption after six months when eaten by osteopaenic, postmenopausal women. Dairy foods have an important role in bone health. Carbonated drinks should not replace milk in the diet. A balanced diet containing food groups and nutrients needed for bone health across the whole lifecycle may help to prevent osteoporosis. Greater efforts are needed to employ preventative strategies which involve dietary and physical activity modifications, if the current situation is to improve. Cite this article: EFORT Open Rev 2017;2:300-308. DOI: 10.1302/2058-5241.2.160079
Performance Study of a Floricultural Greenhouse Surrounded by Shallow Water Ponds
Authors: Misra Debajit , Ghosh Sudip 
Published: June 2017

In the present paper, an innovative low energy-intensive evaporative cooling system has been proposed for greenhouse application in near-tropical regions dominated by hot climate. The system can operate under dual- ventilation mode to maintain a favourable microclimate inside the greenhouse. A single ridge type un-even span greenhouse has been considered, targeting a few species of Indian tropical flowers. The greenhouse has a continuous roof vent as well as adjustable side vents and is equipped with exhaust fans on top and roll-up curtains on the sides. The greenhouse is surrounded by shallow water ponds outside its longitudinal walls and evaporative surfaces partially cover the free water surface. Inside the pond, low cost evaporative surfaces are so placed that they form air channels. Thus, outside air flows through the channels formed by the wetted surfaces over the water surface and undergoes evaporative cooling before entering the greenhouse. A simplified theoretical model has been presented in this paper to predict the inside greenhouse air temperature while ambient weather data are used as model inputs. The study reveals that during average radiation periods, the greenhouse can depends solely on natural ventilation and during peak radiation hours fan-induced ventilation is needed to maintain the required level of temperature. It is seen that under dual-ventilation mode greenhouse, temperature can be kept 3-6 oC lower than ambient temperature when saturation effectiveness is 0.7 and with 75% shading.Article History: Received February 25th 2017; Received in revised form April 14th 2017; Accepted May 4th 2017; Available onlineHow to Cite This Article: Misra, D. and Ghosh, S. (2017) Performance Study of a Floricultural Greenhouse Surrounded by Shallow Water Ponds. International Journal of Renewable Energy Development, 6(2), 137-144.https://doi.org/10.14710/ijred.6.2.137-144
Influence of the Rubber Seed Type and Altitude on Characteristic of Seed, Oil and Biodiesel
Authors: Salni Salni , Hariani Poedji Loekitowati , Hanifa Hanifa Marisa 
Published: June 2017

This research studies the influence of the type of rubber seed that is superior and local, altitude plant in South Sumatra province to the characteristic of seed, oil and biodiesel (methyl ester). Rubber plants planted from local rubber seed by seeds seedlings and superior rubber seed by selected clones. In the study, rubber plants planted at a different altitude, namely in Banyuasin district (18 m above sea level), Prabumulih District (176 m above sea level) and Lahat District (627 m above sea level). The results showed that the weight of the flour, the water content and ash content in the local rubber seeds larger than the superior rubber seed for all altitude, but oil content a large in the superior rubber seeds. The major of fatty acids in the rubber seed oil in all types and altitude are a linoleic acid with a different percentage except local rubber seed oil from Lahat district with the large percentage of octadecanoic acid. Free fatty acids in the oil from the superior seeds rubber of 13.897-15.494 % large than local rubber seed oil was found 9.786-10.399 % for all altitude. By esterification process using sulfuric acid catalyst, Free Fatty Acid (FFA) can be reduced to ≤ 2 %. The methyl ester made from the transesterification process of rubber seed oil after esterification using methanol and sodium hydroxide as catalyst. Analysis of methyl esters includes cetane index, flash point, kinematic viscosity, carbon residue, density, moisture content, water and sediment content and distillation compared with SNI 7182 and ASTM 6751-02. The result indicated that the quality of methyl ester from superior rubber seed oil in the Banyuasin and Prabumulih district better than another methyl ester. The types of rubber seed altitude affect the characteristics of the seed, oil and methyl ester but the altitude are not significantly different.Keywords: rubber seed, type, altitude, oil, biodieselArticle History: Received March 21st 2017; Received in revised form May 5th 2017; Accepted June 2nd 2017; Available onlineHow to Cite This Article: Salni, S, Hariani, P.L. and Marisa, H. (2017) Influence the Rubber Seed Type and Altitude on Characteristic of Seed, Oil and Biodiesel. International Journal of Renewable Energy Development, 6(2), 157-163.https://doi.org/10.14710/ijred.6.2.157-163
Descriptive analysis of 192 cases of breast cancer occurring before age 40 in Yaounde, Cameroon
Authors: Essiben Félix , Foumane Pascal , Meka Esther JNU , Tchakounté Michèle , Dohbit Julius Sama , Nsahlai Christiane , Atenguena Etienne , Njotang Philip Nana , Mboudou Emile Telesphore 
Published: June 2017

Background: Breast cancer is today a global health problem. With 1,671,149 new cases diagnosed in 2012, it is the most common female cancer in the world and accounts for 11.9% of all cancers and it affects more people than prostate cancer. In 2008, The United States statistics showed that, for all cancer that affect women before 40 years, more than 40% of them concerned the breast. The aim of this study was to describe the clinical, histopathological and therapeutic aspects of breast cancer in women under 40 years of age in Yaoundé.Methods: This was a retrospective study with data collected from 192 medical case files of women treated over a period of 12 years, from January 2004 to December 2015 at the Yaounde General Hospital and the Yaounde Gyneco-Obstetric and Pediatric Hospital. Microsoft Epi Info version 3.4.5 and SPSS version 20.0 softwares were used for data analysis.Results: From 2004 to 2015, 1489 cases of breast cancer were treated in both hospitals. Of these, 462 women were less than 40 years old, representing a proportion of 31.0%. The mean age at diagnosis was 33.5±5.0 years and 17.7% of women had a family history of breast cancer. The average time before an initial consultation was 6.7±6.6 months. Most cases were classified as T4 (46.1%). The most common histological type was ductal carcinoma (87.4%). Grades SBR II and SBR III were predominant (76.4%). Axillary dissection (64.4%) and neoadjuvant chemotherapy (43.9%) were the main therapeutic modalities. The overall survival rate at 5 years was 51.2%. Five-year survival rates with no local recurrence and no metastatic occurrence were 35.8% and 43.2% respectively.Conclusions: Breast cancer largely affects women under the age of 40 and is often discovered late, at an advanced stage. The prognosis appears poor. Only screening could facilitate diagnosis at an early stage of the disease for better outcomes.
Current trends of adenotonsillar hypertrophy presentation in a developing country, Nigeria
Authors: Adegbiji Waheed A. , Aremu Shuaib Kayode , Nwawolo Clement C. , Asoegwu Chinyere N. 
Published: June 2017

<p class="abstract"><strong>Background:</strong> Adenotonsillar hypertrophy is a common paediatric disorder in Otorhinolaryngological practice worldwide. The prevalence, clinical manifestations and predisposing factors are well documented in developed countries. However, available data shows differences between the various studies. There is paucity of data from developing countries. <span lang="EN-IN">Thus, this study is aimed at assessing the age group distribution, predisposing factors, clinical manifestation and complications of adenotonsillar hypertrophy in a developing country. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">It is a prospective study of children under 10 years over a period of 24 months. Interviewer assisted questionnaire was administered. Data obtained were statistically analysed using SPSS version 18. </span></p><p class="abstract"><strong>Results:</strong> Two hundred and fifty three, 253 subjects were enrolled into the study. Adenotonsillar hypertrophy affected all age groups studied. A high incidence was noted among the under 2 year olds. The Male: Female ratio was 2:1. Chronic cases constituted 55.7% of our study population. Common predisposing factors were atopy (73.9%), familial history (67.3%) and recurrent upper respiratory tract infection (58.2%). <span lang="EN-IN">The Commonest clinical features were snoring, noisy breathing, tonsillar enlargement and narrowing of postnasal space air column. Failure to thrive, otitis media and rhinosinusitis were the commonly associated complications observed. No death was recorded. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Adenotonsillar hypertrophy is common in our environment. It is important for all primary health care physicians, paediatricians and otorhinolaryngologists to have a clear knowledge on this ailment. Prevention or reduction in incidence is possible.</span></p>
Solitary nodule thyroid: diagnosis and management
Authors: Deepthi M. , Sukthankar P. S. , Narsimloo K. 
Published: June 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Solitary nodule can be a true solitary nodule or a dominant nodule of multinodular goitre or ectopic thyroid or unilateral agenesis. Solitary nodule can be benign or malignant. Purpose of evaluation is to differentiate between the two. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">A prospective study of solitary nodule thyroid (STN) patients presenting to ENT outpatient department, for a period of 3 years from September 2012 to 2015. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Out of 67 patients<strong> </strong>enrolled into study, 53 patients had benign true STN, 9 patients had multinodular goiter (MNG) presenting as solitary nodule and 5 had malignant nodule (7.46%). Among the benign nodules, 25 patients had small solitary nodule (&lt;4 cm size). They were treated medically and followed-up for a period of 1 year. 28 patients with large benign solitary nodules (&gt;4 cm size) were taken up for surgery directly. Hemithyroidectomy was done in benign STN patients (39 patients) and total thyroidectomy was done in malignant nodule and MNG patients and followed-up by lifelong L-T<sub>4 </sub>therapy. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Small benign solitary nodules regress with medical therapy alone. In large solitary nodules, and in those nodules not regressing with medical therapy, hemithyroidectomy is adequate. In MNG and malignant nodules, total thyroidectomy is advocated. Hemithyroidectomy and total thyroidectomy patients were followed - up with suppression and supplementation therapy respectively.</span><span lang="EN-IN">This area being fluorotic belt, there is an increased prevalence of goiter. This study gives a concise guideline in evaluation and management of STN for goiter endemic areas.</span></p><p class="abstract"> </p>
Clinical profile of cases of dysphagia presenting in ENT department: a study from rural tertiary care center
Authors: Datta Ginni , Gupta Manish , Rao Naiya 
Published: June 2017

<p class="abstract"><strong>Background:</strong> Swallowing is a complex motor reflex requiring coordination among the neurologic system and muscles of the oropharynx and oesophagus. Disorders both benign and malignant may interfere with the process and cause dysphagia. We hereby undertake a study in a rural tertiary care centre to study the clinical profile of cases of dysphagia and to find the relative incidence of various etiologies of dysphagia.</p><p class="abstract"><strong>Methods:</strong> A prospective study was conducted upon both out and indoor patients coming to Department of Otorhinolaryngology from January 2016 to January 2017 with predominant symptom of difficulty in swallowing for both solids, liquids or either. Detailed history &amp; examination was done. Further endoscopy, barium swallow, fine needle aspiration cytology (FNAC) &amp; biopsies were done as required. A total of 140 cases were taken into consideration. </p><p class="abstract"><strong>Results:</strong> The mean age was 52.5 years with 60% patients males and 40% females. The commonest etiology of dysphagia was Gastroesophageal reflux disease (GERD) occupying 28.57%of cases. Among them 65% werefemales majority in the age group of 45-55 years. The 2<sup>nd</sup> common cause of dysphagia was growth pharynx 18.5% of cases. Among them 19 cases were diagnosed as growth oropharynx and 7 cases as growth supraglottis extending to hypopharynx. 88.46% were males and all were smokers. The 3<sup>rd</sup> common etiology of dysphagia was obstructive oesophageal causes which included oesophageal malignancies, oesophageal webs, strictures and diverticula in the frequency of 16%, 3%, 3% and 6% respectively. Oesophageal malignancies were mainly adenocarcinoma, all males who were chronic smokers.</p><p><strong>Conclusions:</strong> Dysphagia is a commonly encountered clinical problem &amp; limited studies exist regarding the prevalence of dysphagia etiologies. It is an alarm symptom, malignancy should be ruled out, and warrants early intervention. </p>