bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kajian Penanganan Hepatitis B Berdasarkan Perilaku dan Pemeriksaan Molekuler
Authors: Lestari Gita Dwi , Kafesa Ally 
Published: October 2024

ABSTRACT Hepatitis B is still a major global health problem, chronic hepatitis B can cause cirrhosis and liver cancer. Hepatitis B transmission can be transmitted vertically (from mother to child) or horizontally (from one person to another). Hepatitis B has a genome in the form of a circular double helix of DNA with a length of around 3020-3320 nucleotides. This research aims to study Hepatitis B treatment based on behavior and molecular examination. This research is a type of descriptive research, through literature searches from various national and international journals. The articles used are from 2018 to 2023. The results of the study show that good cognitive knowledge about Hepatitis B will be associated with good behavior towards prevention so that it can reduce the incidence of Hepatitis B, men (84%) and blood type A (41) . %) are more often infected with the hepatitis B virus, pregnant women with reactive HBsAg have good knowledge (83%), the status of children with reactive HBsAg (7.5%), meaning that there is still failure in passive immunization. The conclusion of this research is that treating hepatitis B will be easier based on the characteristics of the virus using a genetic approach. Measurement of HBV DNA levels is carried out using PCR, HBV DNA can be done qualitatively, directly quantitatively, and analyzing mutant HBV DNA. Keywords: Behavior, Hepatitis B, Molecular Examination ABSTRAK Hepatitis B masih menjadi masalah kesehatan global yang utama, hepatitis B kronis dapat menyebabkan sirosis dan kanker hati. Transmisi hepatitis B dapat menyebar secara vertikal (dari ibu ke anak) atau horizontal (dari satu individu ke individu lain). Hepatitis B memiliki genom berupa DNA heliks ganda melingkar dengan panjang sekitar 3020-3320 nukleotida. Penelitian ini bertujuan untuk mempelajari penanganan Hepatitis B berdasarkan perilaku dan pemeriksaan molekuler. Penelitian ini merupakan jenis penelitian deskriptif, melalui penelusuran literatur dari berbagai jurnal nasional dan internasional. Artikel yang digunakan adalah dari tahun 2018 hingga tahun 2023. Hasil penelitian menunjukan laki laki (84%) dan golongan darah A (41%) lebih banyak terinfeksi virus hepatitis B, ibu hamil yang HBsAg-reaktif memiliki pengetahuan yang baik (83%), status HBsAg anak sebanyak (7,5%) reaktif, artinya masih terdapat kegagalan dalam imuisasi pasif. Kadar AST (72%) dan ALT (49%) meningkat dan kadar Albumin (56%) rendah pada pasien hepatitis B. Kesimpulan pada penelitian ini yaitu pengetahuan yang baik akan berhubungan dengan perilaku yang baik terhadap pencegahan serta penularan virus Hepatitis B. Penanganan hepatitis B akan lebih mudah berdasarkan karakteristik virus dengan pendekatan genetik, Pengukuran kadar HBV DNA dilakukan dengan menggunakan PCR, HBV DNA dapat dilakukan secara kualitatif, direk kuantitatif, dan menganalisis HBV DNA mutan. Kata Kunci: Hepatitis B, Pemeriksaan Molekuler, Perilaku
Manajemen Nyeri pada Pasien Penurunan Kesadaran di Ruang Perawatan Intensif : scooping review
Authors: Silviani Sinta , Trisyani Yanny , Emaliyawati Etika 
Published: October 2024

ABSTRACT Pain is an unpleasant sensory and emotional experience resulting from tissue damage. Unconscious patients cannot directly communicate their pain to nurse, but this doesn’t meant they cannot feel pain. Pain in unconscious patients can arise from routine procedures such as prolonged immobilization to invasive procedures like surgery. Nursing interventions to manage pain are necessary to enhance patient comfort. This study aims to examine pain management in unconscious patients in the Intensive Care Unit. This type of research is a scoping review, searching for articles in the PubMed, SCOPUS, and EBSCO databases. The search process used keywords (unconscious patient OR coma OR sopor OR somnolent) AND (pain management OR pain relief OR pain control) AND (intensive care unit OR critical care OR HCU). 45 articles were found that matched the keywords, but only 5 articles were relevant to the review's objectives. Pain management for unconscious patients starts with recognizing pain symptoms, assessing pain, and followed by nursing interventions. Interventions that can be provided include TENS (Transcutaneous Electrical Nerve Stimulation), foot massage, and music therapy. Keywords: Pain Management, Unconscious patient, ICU ABSTRAK Nyeri merupakan pengalaman sensorik dan emosional yang tidak menyenangkan akibat adanya kerusakan jaringan. Pasien yang tidak sadar tidak dapat mengatakan rasa nyeri yang dirasakan secara langsung pada perawat namun bukan berarti tidak dapat merasakan nyeri. Rasa nyeri pada pasien tidak sadar dapat berasal dari tindakan rutin seperti imobilisasi lama, hingga tindakan invasif yang seperti tindakan pembedahan. Intervensi perawat untuk mengatasi nyeri perlu dilakukan untuk meningkatkan kenyamanan pasien. Penelitian ini bertujuan untuk melihat manajemen nyeri pada pasien penurunan kesadaran di ruang Intensive Care. Jenis penelitian ini adalah scooping review, dengan mencari artikel pada database Pubmed, SCOPUS dan EBSCO. Proses pencarian menggunakan kata kunci (unconscious patient OR coma OR soppor OR somnolent) AND (pain management OR pain relief OR pain control) AND (intensive care unit OR critical care OR HCU). Didapatkan 45 artikel sesuai kata kunci namun hanya didapatkab 5 artikel yang sesuai dengan tujuan review. Manajemen nyeri pasien tidak sadar dimulai dari mengenali gejala nyeri, pengkajian nyeri dan dilanjutkan dengan intervensi keperawatan. Intervensi yang dapat diberikan adalah TENS (Transcutaneous Electrical Nerve Stimulation), pijat kaki dan terapi musik. Kata Kunci: Manajemen Nyeri, Pasien Tidak Sadar, ICU
Pengaruh Pemberian Aromaterapi terhadap Kecemasan Hospitalisasi pada Anak
Authors: Azizah Lina Wati Nur , Irdawati Irdawati , Putri Rosalia Dian Arsita 
Published: October 2024

ABSTRACT Hospitalization is a crisis condition that requires sick children to undergo treatment. Children's anxiety responses during hospitalization mostly fall into three categories, namely a crying response when their parents leave them even for a short time, rebellion when given medical therapy, and refusal when an injection is given. Aromatherapy can stimulate the parasympathetic system, which can help reduce blood pressure and anxiety levels. To determine the effect of giving aromatherapy to reduce anxiety in children who are hospitalized. This case study uses a nursing care approach by applying aromatherapy therapy for 15 minutes given to five preschool-aged children who experienced anxiety due to hospitalization as measured using the Visual Anxiety Scale (VAS). Providing an aromatherapy intervention had an effect on reducing the anxiety scale in pre-school-aged children due to hospitalization. Conclusion: The intervention of giving aromatherapy for 15 minutes can reduce anxiety in children undergoing hospitalization. Keywords: Aromatherapy, Anxiety, Hospitalization, Children ABSTRAK Hospitalisasi merupakan kondisi krisis yang mengharuskan anak sakit untuk menjalani perawatan. Respon kecemasan anak saat hospitalisasi paling banyak menunjukkan pada tiga kategori, yaitu respon menangis saat ditinggal orang tua walaupun dalam waktu singkat, memberontak saat diberikan terapi pengobatan, dan penolakan saat akan dilakukan injeksi. Aromaterapi dapat merangsang system parasimpatis yang dapat membantu mengurangi tekanan darah dan menurunkan tingkat kecemasan. Mengetahui pengaruh pemberian aromaterapi untuk mengurangis kecemasan pada anak yang mengalami hospitalisasi. Studi kasus ini menggunakan pendekatan asuhan keperawatan dengan menerapkan terapi pemberian aromaterapi selama 15 menit yang diberikan pada lima anak usia prasekolah yang mengalami kecemasan akibat hospitalisasi yang diukur menggunakan Visual Anxiety Scale (VAS). Pemberian intervensi aromaterapi memberi pengaruh terhadap penurunan skala kecemasan pada anak usia pra sekolah akibat hospitalisasi. Intervensi pemberian aromaterapi selama 15 menit dapat menurunkan kecemasan pada anak yang menjalani hospitalisasi. Kata Kunci: Aromaterapi, Kecemasan, Hospitalisasi, Anak
Analisis Stabilitas Glukosa, Trigliserida Dan Albumin Pada Pooled Serum
Authors: Diona Adara Aurelia , Kafesa Ally 
Published: October 2024

ABSTRACT The use of pooled sera made from leftover patient samples is one alternative to reduce laboratory quality control costs. Researchers aim to determine the stability of pooled serum as a control material for the parameters glucose, triglycerides and albumin. descriptive research with literature review method. The data source used is secondary data. The main source of article search by SINTA- Science and Technology. Analysis of the results used in this study is an analytical method. Month 1 CV glucose levels using pooled serum 5.31%, on commercial serum 7.91%. Month 2 pooled serum 4.87%, commercial serum 6.9%. Month 3 CV pooled serum 2.33%, commercial serum 4.61%. Month 1 CV of triglyceride using pooled serum 1.84%, commercial serum 3.47%. Month 2 pooled serum 1.63%, commercial serum 3.71%. Month 3 CV pooled serum 1.79%, commercial serum 3.30%. Month 1 CV results of albumin levels using pooled serum 5.66%, commercial serum 5.69%. Month 2 CV pooled serum 4.46% and commercial serum 6.32%. Month 3 CV on pooled serum 4.85%, commercial 5.72%. Based on the results of the examination of glucose, triglyceride and albumin levels using pooled serum stored at -20 oC, the results were quite stable in the parameters of triglycerides and albumin. Keywords: Albumin, Glucose, Pooled Serum, Stability, Triglycerides ABSTRAK Pemakaian pooled serum yang terbuat dari sisa sampel pasien merupakan salah satu alternatif untuk mengurangi biaya pengendalian mutu laboratorium. Peneliti bertujuan mengetahui kestabilan pooled serum sebagai bahan kontrol pada parameter glukosa, trigliserida dan albumin. Penelitian desktiptif menggunakan metode literature review. Sumber data yang digunakan merupakan data sekunder. Sumber pencarian artikel utama oleh SINTA- Science and Technology. Analisis data yang digunakan pada penelitian menggunakan metode analitik. CV bulan1 kadar glukosa menggunakan pooled serum 5.31 %, pada serum komersial 7.91%. Bulan 2 pooled serum 4.87 %, serum komersial 6.9%. Bulan 3 CV pooled serum 2.33 % , serum komersial 4.61 %. Bulan 1 CV trigliserida menggunakan pooled serum 1.84%, serum komersial 3.47%. Bulan ke 2 pooled serum 1.63%, serum komersial 3.71%. Bulan 3 CV pooled serum 1.79%, serum komersial 3.30%. Hasil CV bulan 1 kadar albumin menggunakan pooled serum 5.66%, serum komersial sebesar 5.69%. Bulan ke 2 CV pooled serum 4.46% dan serum komersial 6,32%. Bulan ke 3 CV pada pooled serum 4.85% ,komersial 5.72%. Berdasarkan hasil pemeriksaan kadar glukosa, trigliserida dan albumin menggunakan pooled serum yang disimpan pada suhu -20oC menunjukkan hasil yang cukup stabil pada parameter trigliserida dan albumin. Kata Kunci: Albumin, Glukosa, Pooled Serum, Stabilitas, Trigliserida
Kajian Kandidiasis dari Berbagai Sampel Klinis Laboratorium (Urine, Feses, dan Darah)
Authors: Sari Laila , Kafesa Ally 
Published: October 2024

ABSTRACT Candida fungal infection is a group of normal microorganisms in the body. Candida sp. is well adapted to the body (pH, temperature, osmotic pressure, etc.) which is used to avoid the body's defense system, thus changing the saprophytic nature into a pathogen that damages body tissue. To detect Candida sp. infection can be done by examining laboratory clinical samples using urine, feces and blood. This research study to find out how Candida sp. can be found in these clinical samples. The review of scientific articles is descriptive using the cross sectional method. The results of this research study Candida sp. has predisposing factors that trigger its growth, such as age and gender, hygiene, use of antibiotic drugs, increased estrogen hormones. Candidiasis easily infects people with Diabetes Mellitus, Tuberculosis, HIV/AIDS, Systemic Lupus Erythematosus (SLE), and transmission through health services. The Candida species most commonly found in urine clinical samples reaching 63% and feces samples reaching 65.6% were C. albicans species. Meanwhile, the most common species found in clinical blood samples reaching 62.8% was C. non-albicans species. Conclusion: Candida sp. can be found in laboratory clinical samples based on the conditions and predisposing factors in an individual. Keywords: Candidemia, Candidiasis, Laboratory Clinical Samples ABSTRAK Infeksi jamur Candida merupakan sekelompok mikroorganisme normal dalam tubuh. Candida sp. mudah beradaptasi dengan baik pada tubuh (pH, suhu, tekanan osmotik, dan lain – lain) yang dimanfaatkan untuk terhindar dari sistem pertahanan tubuh, sehingga berubah sifat saprofit menjadi patogen yang merusak jaringan tubuh. Untuk mendeteksi infeksi Candida sp. dapat dilakukan dengan pemeriksaan sampel klinis laboratorium menggunakan urine, feses dan darah. Pada kajian penelitian ini untuk mengetahui bagaimana Candida sp. dapat ditemukan dalam sampel klinis tersebut. Kajian artikel ilmiah adalah deskriptif dengan menggunakan metode cross sectional. Hasil kajian penelitian ini Candida sp. memiliki faktor – faktor predisposisi yang memicu pertumbuhannya, seperti usia dan jenis kelamin, higienitas, penggunaan obat antibiotik, peningkatan hormon estrogen. Kandidiasis dengan mudah menginfeksi penderita Diabetes Mellitus, Tuberkulosis, HIV/AIDS, Systemic Lupus Erythematosus (SLE), dan penularan melalui pelayanan kesehatan. Spesies Candida yang paling banyak ditemukan di dalam sampel klinis urine mencapai 63% dan sampel feses mencapai 65,6% adalah spesies C. albicans. Sedangkan, spesies yang paling banyak ditemukan pada sampel klinis darah mencapai 62,8% adalah spesies C. non-albicans. Candida sp. dapat ditemukan pada sampel klinis laboratorium berdasarkan kondisi dan faktor predisposisi pada suatu individu. Kata Kunci: Kandidemia, Kandidiasis, Sampel Klinis Laboratorium
Distribution and Molecular Characterization of Antibiotic-Resistant Pseudomonas aeruginosa in Hospital Settings of Sulaymaniyah, Iraq
Authors: Ali Seenaa Muhammed , Soor Taib Ahmed Hama , Ahmed Gashin Awat , Mhdin Glena Aziz , Othman Gulabakh Ali , Faiq Sarkhel Mhamad 
Published: October 2024

Abstract

Pseudomonas aeruginosa is a significant pathogen in hospital settings, notorious for its role in hospital-acquired infections and its ability to develop resistance to multiple antibiotics. This study investigates the prevalence, distribution, and antibiotic resistance gene profiles of P. aeruginosa in seven hospitals in Sulaymaniyah City. A total of 300 samples were collected from various hospital surfaces including mops, sinks, medical equipment, beds, desks, and floors. Using bacteriological, biochemical, and molecular methods, 66 isolates were confirmed as Pseudomonas species, with 26 identified as P. aeruginosa. Antibiotic susceptibility testing revealed resistance rates of 23.3% to streptomycin, 13.6% to tobramycin, 22.7% to moxifloxacin, 21.2% to levofloxacin, and 22.7% to norfloxacin. Furthermore, the antibiotic resistance gene detection showed the presence of the bla
CTX-M, bla
SHV, qnrB, and bla
ACC-1 genes among the isolates. The study highlights a 22% contamination rate of hospital surfaces with Pseudomonas species, emphasizing the urgent need for enhanced infection control measures and targeted antimicrobial stewardship to manage and reduce the spread of multidrug-resistant P. aeruginosa.
Preparation of Magnesium Titanate by Using Magnesium Chloride a Byproduct of Titanium Plant
Authors: Neelamegam David Solomon Godwin Babu , Ponnam Vijetha , Tondepu Subbaiah 
Published: October 2024

This study explores the preparation of magnesium titanate using magnesium chloride, a byproduct of the titanium production plant as a precursor. The synthesis involves the reaction of MgCl2 with titanium tetrachloride under controlled thermal conditions. Initially, MgCl2 and TiCl4 are thoroughly mixed in stoichiometric proportions with an excess of oxalic acid solution to produce magnesium titanyl oxalate. The mixture is then subjected to a calcination process at temperatures ranging from 300 °C to 1000 °C in an oxygen-rich environment. The physicochemical properties of the synthesized MgTiO3 were analyzed using EDS, XRD, TG/DTA, SEM, and particle size analysis. This comprehensive set of analytical techniques provides a thorough understanding of the elemental, structural, thermal, morphological and physical characteristics of magnesium titanate. The formation of pure magnesium titanate is confirmed at temperatures above 800 °C, with lower temperatures leading to the presence of intermediate phases such as MgTi2O5. The synthesized MgTiO3 exhibits a homogeneous microstructure with well-defined grain boundaries, indicating successful preparation of the desired ceramic material.
Implementation of Parallel Applications on Linear Systolic and Star Topologies by Using Multistage Omega Network
Authors: Alsaffar Qusay Samir , Ben Ayed Leila 
Published: October 2024

Contemporary computer architecture comprises multicomputer settings. Multiple computers provide the facility of high performance to implement multiple threads that are faster and concurrently with different processors that can execute tasks simultaneously. The challenges are as follows: cost and high performance. Certain firms have to provide funding to establish data centers that need locations, hardware, and technicians. After the passage of a period of time, such equipment requires maintenance (updating and upgrading) to take place on it. This paper tackles these challenges by passing the drawbacks of data centers. It provides an algorithm that simulates a virtual machine, as one client is to be connected with eight servers to implement two applications namely convolution and mathematical operations. To represent different topologies, the algorithm simulates supercomputer systems by applying multistage omega network topology and parallel processing. Two types of topologies execute linear systolic and star, and is implemented on transmission control protocol (TCP) and user datagram protocol (UDP) protocols. The goal of this paper is to provide a kernel that draws near a cloud computing system by exploiting the JAVA programming language with its techniques (threading, socket, socket server, Datagram socket, and datagram packet). The results offer the connection between the client and servers to be successfully simulated by using multistage omega network. The linear systolic and star topologies are simulated in virtual parallel processing.
Comparación de los diferentes métodos de diagnóstico para Helicobacter pylori, una visión de nuevas alternativas diagnósticas
Authors: Rivera Cáceres Estefanía Fernanda , Ortiz Tejedor Jonnathan Gerardo 
Published: October 2024

Introducción. Se estima que aproximadamente la mitad de la población mundial ha sido infectada con H. pylori en algún momento; generalmente, la infección ocurre en la niñez, y puede persistir de por vida en el estómago si no se trata. Objetivo. Comparar los diferentes métodos de diagnóstico para H. pylori, y describir nuevas alternativas diagnósticas disponibles en la actualidad. Metodología. Se llevó a cabo una búsqueda detallada en bases de datos científicas, eligiendo estudios pertinentes según criterios determinados. Se consideraron características propias de cada método de diagnóstico, ventajas y desventajas, limitaciones presentes, utilizando tablas y compilaciones narrativas. Resultados. Se identificaron métodos de diagnóstico precisos y eficientes que permiten identificar de manera temprana la presencia de H. pylori. Además, se describieron métodos de diagnóstico molecular como la reacción en cadena de la polimerasa (PCR). Conclusión. Esta revisión enfatiza la relevancia de un diagnóstico oportuno para H. pylori destacando los nuevos métodos de diagnóstico existentes y el requerimiento de investigar más; ya que, a pesar de los avances en el diagnóstico, aún existen desafíos y limitaciones que deben superarse. Área de estudio general: Microbiología. Área de estudio específica: Bacteriología. Tipo de estudio: Artículo original.
Accelerated innervation of biofabricated skeletal muscle implants containing a neurotrophic factor delivery system
Authors: Mashanov Vladimir , Billman Erika , Poerio Aurelia , Kaufmann Mary , Lai Dehui , Vaughan J. William , Kim Ickhee , Ju Young Min , Atala Anthony , Yoo James J. , Kim Ji Hyun 
Published: October 2024

IntroductionVolumetric muscle loss (VML) is one of the most severe and debilitating conditions in orthopedic and regenerative medicine. Current treatment modalities often fail to restore the normal structure and function of the damaged skeletal muscle. Bioengineered tissue constructs using the patient’s own cells have emerged as a promising alternative treatment option, showing positive outcomes in fostering new muscle tissue formation. However, achieving timely and proper innervation of the implanted muscle constructs remains a significant challenge. In this study, we present a clinically relevant strategy aimed at enhancing and sustaining the natural regenerative response of peripheral nerves to accelerate the innervation of biofabricated skeletal muscle implants.MethodsWe previously developed a controlled-release neurotrophic factor delivery system using poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating ciliary neurotrophic factor (CNTF) and glial cell line-derived neurotrophic factor (GDNF). Here, we incorporate this neurotrophic factor delivery system into bioprinted muscle constructs to facilitate innervation in vivo.ResultsOur results demonstrate that the neurotrophic factors released from the microspheres provide a chemical cue, significantly enhancing the neurite sprouting and functional innervation of the muscle cells in the biofabricated muscle construct within 12 weeks post-implantation.DiscussionOur approach provides a clinically applicable treatment option for VML through accelerated innervation of biomanufactured muscle implants and subsequent improvements in functionality.