bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute interstitial nephritis in T‐cell leukemia in a pediatric patient
Authors: Biro Erika , Szikszay Edit , Pethő‐Orosz Petronella , Bigida László , Balla György , Szabó Tamás 
Published: September 2016

AbstractAcute lymphoid leukemia is the most frequently occurring malignancy in childhood, but acute tubulointerstitial nephritis with associated acute renal failure as the leading manifestation of leukemia is extremely rare. Only a few pediatric cases have been described in the literature. We present a surprising case in which physical examination and initial investigation were not typical for leukemia. Ultrasound showed only modest kidney enlargement while laboratory results indicated acute renal failure. Renal biopsy indicated tubulointerstitial nephritis, and subsequent steroid treatment led to sudden clinical improvement. One month later, however, the patient returned with typical clinical features of leukemia. Re‐evaluation of the original kidney biopsy block indicated T‐cell acute lymphoid leukemia. The present case highlights the importance of renal biopsy.
Novel compound heterozygous mutations in a Japanese girl with Janus kinase 3 deficiency
Authors: Sato Takeshi , Okano Tsubasa , Tanaka‐Kubota Mari , Kimura Shunsuke , Miyamoto Satoshi , Ono Shintaro , Yamashita Motoi , Mitsuiki Noriko , Takagi Masatoshi , Imai Kohsuke , Kajiwara Michiko , Ebato Takasuke , Ogata Shohei , Oda Hirotsugu , Ohara Osamu , Kanegane Hirokazu , Morio Tomohiro 
Published: September 2016

AbstractSevere combined immunodeficiency (SCID) is the most severe form of primary immunodeficiency disease, and it is characterized by marked impairment in cellular and humoral immunity. Mutations in several genes cause SCID, one of which is Janus kinase 3 (JAK3), resulting in autosomal recessive T(–)B(+)NK(–) SCID. Only three patients with JAK3‐deficient SCID have been reported in Japan. We herein describe the case of a 6‐month‐old girl with pneumocystis pneumonia, who was diagnosed with SCID with compound heterozygous JAK3 mutations (c.1568G>A + c.421‐10G>A). One of the mutations was previously reported in another Japanese patient. The other mutation was a novel and de novo relatively deep intronic mutation causing aberrant RNA splicing. The patient was successfully treated with bone marrow transplantation from a haploidentical donor.
Maternal Prepregnancy Body Mass Index and Small for Gestational Age Births in Chinese Women
Authors: Zhang Bin , Yang Shaoping , Yang Rong , Wang Jing , Liang Shengwen , Hu Ronghua , Xian Hong , Hu Ke , Zhang Yimin , Weaver Nancy L. , Wei Hongming , Vaughn Michael G. , Peng Hui , Boutwell Brian B. , Huang Zhen , Qian Zhengmin 
Published: September 2016

AbstractBackgroundBoth high and low prepregnancy body mass index (BMI) has been associated with small for gestational age births (SGA; birthweight below the population specific 10th centile for the gestational age), but results remain inconsistent. We examined the association between maternal BMI and SGA, and evaluated if the associations were modified by preterm birth (being born prior to 37 weeks) status.MethodsA population‐based cohort study was conducted in Wuhan, China from June 2011, to June 2013. Women who delivered a non‐malformed livebirth (n = 76 695) were included using the Wuhan Maternal and Child Health Management Information System. Log‐binomial regression models were used to analyse the associations between prepregnancy BMI, categorized using thresholds adapted to the Chinese population, and SGA. Stratified analyses were used to examine the relationship of prepregnancy BMI to preterm‐SGA and term‐SGA.ResultsOf the 76 695 live births, 3058 (4.0%) were delivered preterm. For babies born at term, prepregnancy underweight (<18.5 kg/m2) was associated with an increased risk of SGA, the adjusted risk ratio (RR) was 1.41 (95% confidence interval (CI) 1.33, 1.49), whereas, being overweight (24.0–27.9 kg/m2) was associated with a decreased risk (RR 0.84, 95% CI 0.74, 0.94). For babies born preterm, prepregnancy underweight was not associated with risk of SGA, but being overweight was associated with an increased risk (RR 1.57, 95% CI 1.04, 2.35).ConclusionsThese data suggest that the association of overweight and underweight prepregnancy BMI and SGA differs depending on whether the baby is full term or preterm.
Integrating ecosystem functions into restoration ecology—recent advances and future directions
Authors: Kollmann Johannes , Meyer Sebastian T. , Bateman Rolf , Conradi Timo , Gossner Martin M. , de Souza Mendonça Milton , Fernandes Geraldo W. , Hermann Julia‐Maria , Koch Christiane , Müller Sandra C. , Oki Yumi , Overbeck Gerhard E. , Paterno Gustavo B. , Rosenfield Milena F. , Toma Tiago S. P. , Weisser Wolfgang W. 
Published: September 2016

AbstractIncluding ecosystem functions into restoration ecology has been repeatedly suggested, yet there is limited evidence that this is taking place without bias to certain habitats, species, or functions. We reviewed the inclusion of ecosystem functions in restoration and potential relations to habitats and species by extracting 224 publications from the literature (2004–2013). Most studies investigated forests, fewer grasslands or freshwaters, and fewest wetlands or marine habitats. Of all studies, 14% analyzed only ecosystem functions, 44% considered both biotic composition and functions, 42% exclusively studied the biotic component, mostly vascular plants, more rarely invertebrates or vertebrates, and least often microbes. Most studies investigating ecosystem functions focused on nutrient cycling (26%), whereas productivity (18%), water relations (16%), and geomorphological processes (14%) were less covered; carbon sequestration (10%), decomposition (6%), and trophic interactions (6%) were rarely studied. Monitoring of ecosystem functions was common in forests and grasslands, but the functions considered depended on the study organisms. These associations indicate research opportunities for certain habitats, species, and functions. Overall, the call to include ecosystem functions in restoration has been heard; however, a lack of clarity about the ecosystem functions to be included and deficits of feasible field methods are major obstacles for a functional approach. Restoration ecology should learn from recent advances in rapid assessment of ecosystem functions, and by a closer integration with biodiversity–ecosystem functioning research. Not all functions need to be measured in all ecosystems, but more functions than the few commonly addressed would improve the understanding of restored ecosystems.
High‐resolution riparian vegetation mapping to prioritize conservation and restoration in an impaired desert river
Authors: Macfarlane William W. , McGinty Christopher M. , Laub Brian G. , Gifford Suzanne J. 
Published: September 2016

AbstractIn highly impaired watersheds, it is critical to identify both areas with desirable habitat as conservation zones and impaired areas with the highest likelihood of improvement as restoration zones. We present how detailed riparian vegetation mapping can be used to prioritize conservation and restoration sites within a riparian and instream habitat restoration program targeting 3 native fish species on the San Rafael River, a desert river in southeastern Utah, United States. We classified vegetation using a combination of object‐based image analysis (OBIA) on high‐resolution (0.5 m), multispectral, satellite imagery with oblique aerial photography and field‐based data collection. The OBIA approach is objective, repeatable, and applicable to large areas. The overall accuracy of the classification was 80% (Cohen's κ = 0.77). We used this high‐resolution vegetation classification alongside existing data on habitat condition and aquatic species' distributions to identify reaches' conservation value and restoration potential to guide management actions. Specifically, cottonwood (Populus fremontii) and tamarisk (Tamarix ramosissima) density layers helped to establish broad restoration and conservation reach classes. The high‐resolution vegetation mapping precisely identified individual cottonwood trees and tamarisk thickets, which were used to determine specific locations for restoration activities such as beaver dam analogue structures in cottonwood restoration areas, or strategic tamarisk removal in high‐density tamarisk sites. The site prioritization method presented here is effective for planning large‐scale river restoration and is transferable to other desert river systems elsewhere in the world.
Tree islands: the bellwether of Everglades ecosystem function and restoration success
Authors: Wetzel Paul R. , Sah Jay P. , Ross Michael S. 
Published: September 2016

AbstractEverglades tree islands are patches of woody vegetation ranging in size from 0.1 to 70 ha embedded in a marsh matrix. Tree islands are an essential component of the tree island–ridge–slough topographic continuum and the trees provide a mechanism for the accumulation of phosphorus in the landscape, enhancing landscape biocomplexity. This article reviews the literature of tree island ecology and describes the predicted effects of five ecosystem restoration scenarios on tree islands. Elevations of the highest points on 404 islands across the Everglades were used to assess the effects of the scenarios at a landscape level, while the plant communities of nine islands were modeled to assess local effects. Evaluation of the restoration scenarios were based on three critical components needed to maintain and restore tree islands: hydrology that allows the survival of woody species, seasonally appropriate water flow to move nutrients off the heads of islands, and oligotrophy. All restoration options generally improved water conditions for tree growth, although flooding of islands in some areas was predicted to increase. Scenarios with the greatest amount of decompartmentalization and largest capacity to remove phosphorus from water entering the Everglades provided the best chance of delivering vigorous pulses of sheet flow in directions parallel to historic flows and maintaining oligotrophy. Tree islands are “bellwethers” of restoration actions because their maintenance on the landscape requires multiple ecosystem functions.
Regulatory Entry Barriers, Rent Shifting and the Home Market Effect
Authors: Tobal Martín 
Published: September 2016

AbstractThis paper introduces regulatory entry barriers in a model of the home market effect. The entry barriers generate local rents that have unexpected but significant implications. First, the home market effect is magnified. Second, when countries are sufficiently unequal in size and rents are sufficiently large, symmetric reductions in trade costs reduce welfare in the small country. Third, entry barriers increase the large country's market size and, surprisingly, can increase its welfare. Fourth, a unilateral increase in trade protection shifts foreign rents to the home country. This rent‐shifting effect amplifies the standard production relocation motive for trade policy intervention.
Phylogeography and taxonomy of the Psorodonotus caucasicus (Orthoptera, Tettigoniidae) group: independent double invasion of the Balkans from the Caucasus
Authors: KAYA SARP , ÇIPLAK BATTAL 
Published: September 2016

AbstractHigh mountain ranges within and around Anatolia have played an important role in the biogeography of mountainous organisms, which are threatened by climate change. Using the Psorodonotus caucasicus species group (PCG), whose range is the Caucasus, Anatolia and the Balkans, as a model group, this study aims to determine the importance of Anatolian mountain ranges and to estimate possible future effects of global warming on such lineages by establishing an analogy between interglacial dynamics and global warming. Twenty populations, representing all extant species of the PCG, were studied. Sequences of four mitochondrial loci and three nuclear loci were obtained and used in phylogenetic, time estimation and phylogeographic analyses of PCG members. Additionally, ecological modelling analyses were conducted to estimate the range of PCG members at present and during the last glacial maximum and the last interglacial, with the aim of determining the roles of altitudes and glacial cycles in shaping the distribution of the PCG. Phylogenetic analyses supported the monophyly of the PCG as a whole and each individual species with the exception of P. suphani. The radiation of the PCG started approximately 3 Ma, according to beast. Species distribution models suggested a wider range during the last glacial maximum than during the last interglacial and at present, but these models also suggested that present conditions represent a substantial range loss. The PCG dispersed to the Balkans through two independent corridors from the Caucasus. The following conclusions were reached based on the results: (i) the uplift of the Pontic and East Anatolian Blocks during the mid‐Pliocene and the closing of the Mediterranean and the Paratethys connection in the Plio–Pleistocene and the mid‐Pleistocene Transition are the main events that triggered the radiation of the PCG; (ii) the PCG radiated from a Caucasian origin and invaded the Balkans twice, first through Northern Anatolia and second via the ‘Taurus Way’ dispersal corridor; (iii) lowlands are a barrier to the dispersal of PCG members; (iv) the last four intense glacial periods had little effect on the radiation of the PCG; (v) the range of the PCG has receded substantially from its original southern margin, and P. salmani and P. anatolicus have become extinct since the 1950s, possibly because of global warming; and (vi) automatic species delimitation tests supported species status of the morphospecies P. caucasicus, P. macedonicus, P. fieberi, P. illyricus and P. ebneri, but not that of P. suphani, thus, P. suphani Taylan & Sirin, 2014 syn.n. synonymized with P. caucasicus (Fischer von Waldheim, 1846).
CARACTERIZACIÓN DE UNIDADES DE ADOBE SOMETIDAS A RADIACIÓN UVA
Authors: Uribe Kaffure Claudia , Ramos Cañón Alfonso Mariano , Camacho Tauta Javier Fernando 
Published: September 2016

<p>Este trabajo muestra los resultados obtenidos en la variación de las propiedades mecánicas de unidades de adobe sometidas a factores ambientales simulados de radiación y condensación. Para ello se estudiaron adobes de más de trecientos años de antigüedad, extraídos de la Capilla Doctrina de Tausa, y adobes nuevos construidos en laboratorio. Las piezas de adobe fueron sometidos a ciclos alternados de 6 horas de radiación UVA y 2 horas de condensación durante 360, 720, 1440, 2160 y 2880 horas de exposición, tiempos en los cuales se analizó la variación en las propiedades mecánicas del adobe mediante ensayos de esfuerzo deformación. Se logró concluir que la exposición a radiación UVA acelera la variación en las propiedades mecánicas de los adobes nuevos, mientras que al adobe de la capilla de Tausa no le causa ningún efecto mecánico. Igualmente, se pudo establecer que los cambios en la resistencia del adobe están dados por la variabilidad en la cohesión, ya que el ángulo de fricción de este material no se modifica con el tiempo. </p>
Valoración patrimonial en el Valle del Cauca, Colombia. El cambio de uso como alternativa de conservación de las estaciones de tren abandonadas
Authors: Villegas Corey María Claudia 
Published: September 2016

<p>Al observar el estado de deterioro de gran parte del patrimonio construido del Valle del Cauca catalogado como Bien de Interés Cultural de la Nación (BIC) por el Estado colombiano, se evidencia el desconocimiento que la comunidad tiene sobre estos bienes y surge la necesidad de generar acciones que permitan su conservación. Sin embargo, también hay que reconocer los avances y logros en términos de protección del Ministerio de Cultura. A lo largo de los años han sido frecuentes situaciones de desconocimiento del marco jurídico por parte de los tres actores fundamentales (el propietario, el Estado y el arquitecto) que intervienen en la construcción de memoria e identidad a partir de la valoración física de edificios representativos de nuestra historia. El Gobierno custodia el patrimonio nacional y legisla las normas generales para su protección, sin embargo, la comunicación de los estamentos con la población se basa en artículos y decretos que no permean la comunidad ni la ilustran, lo que genera un desconocimiento general que en muchos casos incluye hasta a los mismos propietarios de los inmuebles catalogados. Las estaciones<br />de tren en el Valle del Cauca representan más del 50% del patrimonio construido de ese departamento y son los edificios más deteriorados; el análisis que se realiza en este estudio propende por establecer una línea de base de las causas de ese estado y las posibles acciones futuras en las que se incluya la comunidad que se relaciona e<br />identifica con el bien patrimonial.</p>
Visiones críticas sobre el estado en la antropología y la administración pública: miradas al vaivén
Authors: García Reyes Paola , Sanabria Pablo 
Published: September 2016

<p>En este artículo hacemos una revisión general de las principales aproximaciones críticas al estado desde dos ciencias sociales con aparentes caminos diferentes: la antropología y la administración pública. Revisamos distintas aproximaciones críticas al rol del estado y a las teorías mismas, y su evolución en el tiempo a partir de una metáfora de vaivén. Los movimientos pendulares caracterizan los avances acumulativos en teorías, aproximaciones y explicaciones que vienen y van en busca de lo estatal, y cuestionan su impacto y su rol en la sociedad. A partir de ese marco presentamos los textos que hacen parte de este número y que contribuyen a la construcción de miradas críticas al estado desde las ciencias sociales en América Latina.</p>
Immunogenicity of 13-Valent Conjugate Pneumococcal Vaccine in Patients 50 Years and Older with End-Stage Renal Disease and on Dialysis
Authors: Mitra Subhashis , Stein Gary E. , Bhupalam Shyam , Havlichek Daniel H. 
Published: September 2016

ABSTRACT
Patients with end-stage renal disease (ESRD) and on dialysis are at increased risk of pneumococcal disease. We evaluated the immunogenicity of the 13-valent pneumococcal conjugate vaccine (PCV13) in this population. Eligible patients with ESRD and on dialysis were given a single dose of PCV13. The concentrations of serum antibodies against 13 pneumococcal capsular polysaccharides were measured at the baseline and at 2 and 12 months postvaccination. A response to the vaccine was defined as a ≥2-fold increase in antibody concentration from that at the baseline and an absolute postvaccination value of at least 1 μg/ml. Seventeen patients completed the study. Increases in the concentrations of antibodies to the vaccine serotype were demonstrated 2 months after vaccination. The geometric mean antibody concentrations at 12 months postvaccination declined by 38% to 72% compared to those measured at 2 months postvaccination. A response to at least 1 serotype in the vaccine was seen in all patients at both 2 and 12 months postvaccination. The overall rate of the response to each individual vaccine serotype varied between 23.5% and 94.1% at 2 months postvaccination and 23.5% and 65% at 12 months postvaccination. Pain at the injection site was the most common local reaction. Vaccination with PCV13 induces antibody responses to vaccine serotypes in patients with ESRD and on dialysis at 2 months postvaccination. However, the decline in antibody concentrations at 12 months postvaccination with a conjugate pneumococcal vaccine requires further study. (This study has been registered at ClinicalTrials.gov under registration no. NCT01974817.)
Natural Development of Antibodies against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis Protein Antigens during the First 13 Years of Life
Authors: Borges Igor C. , Andrade Dafne C. , Cardoso Maria Regina A. , Toppari Jorma , Vähä-Mäkilä Mari , Ilonen Jorma , Knip Mikael , Hyöty Heikki , Veijola Riitta , Simell Olli , Jartti Tuomas , Käyhty Helena , Ruuskanen Olli , Nascimento-Carvalho Cristiana M. 
Published: September 2016

ABSTRACT

Conserved protein antigens have been investigated as vaccine candidates against respiratory pathogens. We evaluated the natural development of antibodies against
Streptococcus pneumoniae
,
Haemophilus influenzae
, and
Moraxella catarrhalis
proteins during childhood. Serum samples were collected from 50 healthy children from their first months to age 13 years (median sampling interval, 6 months). We also analyzed serum samples from 24 adults. Serum IgG antibodies against eight pneumococcal proteins (Ply, CbpA, PspA 1 and 2, PcpA, PhtD, StkP-C, and PcsB-N), three
H. influenzae
proteins, and five
M. catarrhalis
proteins were measured using a multiplexed bead-based immunoassay. Antibody levels were analyzed using multilevel mixed-effects regression and Spearman's correlation. Antibody levels against pneumococcal proteins peaked at 3 to 5 years of age and then reached a plateau. Antibody levels against
H. influenzae
proteins peaked during the second year and then stabilized. Antibody levels against
M. catarrhalis
proteins peaked during the first year and then slowly decreased. Peak antibody levels during childhood were higher than those of adults. Correlations among pneumococcal antibody levels were highest among anti-CbpA, anti-PcpA, and anti-PhtD antibodies (
r
= 0.71 to 0.75;
P
< 0.001). The children presented 854 symptomatic respiratory infections on 586 occasions. Symptomatic respiratory infections did not improve prediction of antibody levels in the regression model. The maturation of immune responses against the investigated pneumococcal proteins shares similarities, especially among CbpA, PcpA, and PhtD. Antibody production against
H. influenzae
and
M. catarrhalis
proteins starts early in life and reaches peak levels earlier than antibody production against the pneumococcal proteins. Basal antibody levels are not related to the occurrence of symptomatic respiratory infections.
Health conditions detected in a comprehensive periodic health evaluation of 558 professional football players
Authors: Bakken Arnhild , Targett Stephen , Bere Tone , Adamuz Maria-Carmen , Tol Johannes L , Whiteley Rod , Wilson Mathew G , Witvrouw Erik , Khan Karim M , Bahr Roald 
Published: September 2016

BackgroundDespite the widespread use of periodic health evaluation (PHE) to detect and prevent injury and illness in athletes, its effectiveness in detecting health conditions and relevant risk factors is still debated.AimTo assess health conditions detected by a comprehensive PHE in professional male football players and evaluate their consequences for participation clearance.MethodsA total of 558 professional football players in Qatar completed a PHE prior to the 2013 or 2014 seasons: history, general medical (including blood test), cardiovascular (12-lead ECG and echocardiography) and a musculoskeletal examination, including a specific test battery targeting lower extremity strength and flexibility. On the basis of the PHE, players were either cleared or not cleared for participation.ResultsIn 533 players (95.5%), at least one health condition was detected requiring treatment or follow-up. Vitamin D deficiency or insufficiency (≤30 ng/mL) was the most common medical condition (n=499, 89.4%), followed by hepatitis B non-immunity or infection (n=164, 29.4%). Cardiac screening identified 48 players (8.6%) with one or more abnormal findings (ECG (n=19, 3.4%) and echocardiography (n=14, 2.5%)). Musculoskeletal conditions were observed in 180 players (32.3%); injuries to or strength deficits of the hip/groin and thigh accounted for the largest proportion. Medical clearance was temporarily not given in 69 players (12.4%), while further examinations were being conducted. One player was disqualified from competitive football.ConclusionsPHE revealed a high prevalence of health conditions requiring treatment or follow-up in professional footballers; however, only 12.4% of conditions impacted on final clearance for participation.