bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduktion postoperativer Schmerzen durch Manuelle Medizin bei Erwachsenen nach Tonsillektomie
Authors: Arens Christoph , Scholz Friedrich Gunther , Kropf Siegfried , Voigt-Zimmermann Susanne 
Published: October 2017

Zusammenfassung
Hintergrund Postoperativer Schmerz nach Tonsillektomie (TE) kann in der Regel durch die Gabe von Analgetika aus der Gruppe der nicht
steroidalen Antirheumatika (NSAR) suffizient behandelt werden. Bei einigen Patienten besteht jedoch eine außergewöhnlich therapieresistente
Schmerzsymptomatik, welche zudem häufig einseitig stärker ausgeprägt ist. Unsere klinisch praktische Erfahrung hat gezeigt, dass bei diesen
Patienten häufig eine Blockierung der oberen Kopfgelenke vorliegt, die durch Manuelle Medizin (MM) erfolgreich therapiert werden kann. In
dieser prospektiven, randomisierten, placebo-kontrollierten, einfach verblindeten Studie sollte deshalb untersucht werden, ob sich der
schmerzlindernde Effekt dieser Therapie statistisch nachweisen lässt.
Material und Methoden 52 erwachsene Patienten mit außergewöhnlich starken (VAS > 4) und / oder einseitigen Schmerzen nach TE (1.
bis 4. Tag postoperativ) wurden hinsichtlich des Schmerzverlaufs mittels Visueller Analogskala (VAS) zu 4 Zeitpunkten untersucht: direkt vor
(t0) und sofort nach der MM (t1), dann 4 Stunden nach MM (t2) sowie 24 Stunden nach MM (t3).
Ergebnisse Die Ergebnisse zeigen eine signifikant höhere Schmerzreduktion (jeweils als Differenz zu t0) in der Verum- als in der
Placebogruppe zum Zeitpunkt t1 und t3 (t1: p = 0,012, t3: p = 0,012, beides Bonferroni-adjustiert). Zum Zeitpunkt t2 war die Differenz mit
p = 0,54 nicht signifikant.
Schlussfolgerungen Anhand der Studie konnte die Wirksamkeit von Manueller Medizin zur Schmerzreduktion bei erwachsenen Patienten mit
außergewöhnlich starken bzw. einseitigen Schmerzen nach TE und Hypomobilität der Halswirbelsäule nachgewiesen werden.
Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production
Authors: Nakamura Masaki , Zhang Yin , Yang Yunlong , Sonmez Ceylan , Zheng Wenyi , Huang Guichun , Seki Takahiro , Iwamoto Hideki , Ding Bo , Yin Linlin , Foukakis Theodoros , Hatschek Thomas , Li Xuri , Hosaka Kayoko , Li Jiaping , Yu Guohua , Wang Xinsheng , Liu Yizhi , Cao Yihai 
Published: October 2017

Significance
Understanding the molecular mechanisms underlying drug resistance of antiangiogenic therapy is crucial to improvement of therapeutic efficacy in cancer patients. Our data uncover a mechanism by which the off-tumor targets compromise anti-VEGF drug sensitivity. The therapeutic implication of our findings poses a concept that blocking the off-tumor targets of antiangiogenic drugs are crucial for improvement of therapeutic efficacy. Based on our findings, modest inhibition of excessive EPO production is recommended for improvement of antiangiogenic therapy. Our work will result in a significant paradigm shift and conceptual advances as to improvement of both quality-of-life and overall survivals of antiangiogenic drug-treated cancer patients.
Competing English, Spanish, and French alabaster trade in Europe over five centuries as evidenced by isotope fingerprinting
Authors: Kloppmann W. , Leroux L. , Bromblet P. , Le Pogam P.-Y. , Cooper A. H. , Worley N. , Guerrot C. , Montech A. T. , Gallas A. M. , Aillaud R. 
Published: October 2017

Significance
Gypsum alabaster in medieval artwork equaled or even surpassed the importance of marble for religious sculptures and effigies. Based on isotope fingerprints, a large corpus of European alabaster sculptures are linked to historical quarries and trade in the Middle Ages and Renaissance period. We demonstrate that English alabaster export was competed on the continent by the Spanish and by a particularly long-lived (>500 y) French Alpine trade. Our study reveals historical trade routes and transport, the diversity of supply of medieval artists and workshops, as well as the presence and provenance of restoration materials.
Relativism and the expressivist bifurcation
Authors: González de Prado Salas Javier 
Published: October 2017

AbstractTraditional expressivists want to preserve a contrast between the representational use of declarative sentences in descriptive domains and the non-representational use of declarative sentences in other areas of discourse (in particular, normative speech). However, expressivists have good reasons to endorse minimalism about representational notions, and minimalism seems to threaten the existence of such a bifurcation. Thus, there are pressures for expressivists to become global anti-representationalists. In this paper I discuss how to reconstruct in non-representationalist terms the sort of bifurcation traditional expressivists were after. My proposal is that the relevant bifurcation can be articulated by appeal to the contrast between relativistic and non-relativistic assertoric practices. I argue that this contrast, which can be specified without appeal to representational notions, captures the core intuitions behind the expressivist bifurcation (in particular, it captures the anti-realist intuitions motivating many expressivist proposals).
Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology
Authors: Sironen Tarja , Sane Jussi , Lokki Marja-Liisa , Meri Seppo , Andersson Leif C , Hautala Timo , Kauma Heikki , Vuorinen Sakari , Rasmuson Johan , Evander Magnus , Ahlm Clas , Vaheri Antti 
Published: October 2017

Abstract
The case-fatality rate of hantavirus disease depends strongly on the causative hantavirus, ranging from 0.1% to 40%. However, the pathogenesis is not fully understood, and at present no licensed therapies exist. We describe fatal cases caused by Puumala hantavirus indicating involvement of complement activation and vascular leakage.
Simultaneous cell traction and growth measurements using light
Authors: Sridharan Shamira , Li Yanfen , Foucard Louis , Majeed Hassaan , Bhaduri Basanta , Levine Alex , Kilian Kristopher , Popescu Gabriel 
Published: October 2017

ABSTRACTUnderstanding cell mechanotransduction is important for discerning matrix structure-cell function relationships underlying health and disease. Despite the crucial role of mechanochemical signaling in phenomena such as cell migration, proliferation, and differentiation, measuring the cell-generated forces at the interface with the extracellular matrix during these biological processes remains challenging. An ideal method would provide continuous, non-destructive images of the force field applied by cells, over broad spatial and temporal scales, while simultaneously revealing the cell biological process under investigation. Toward this goal, we present the integration of a new real-time traction stress imaging modality, Hilbert phase dynamometry (HPD), with the technique of spatial light interference microscopy (SLIM) for label free monitoring of cell growth. HPD relies on extracting the displacement field in a deformable substrate, which is chemically patterned with a fluorescent grid. The displacements introduced by the cell are captured by thephaseof the periodic signal associated with the grid, borrowing concepts from holography. The displacement field is uniquely converted into forces by solving an elasticity inverse problem. Because the measurement of displacement only uses the epi-fluorescence channel of an inverted microscope, we can simultaneously achieve measurements in transmission. We performed SLIM and extracted cell mass on the same field of view in addition to the measured displacement field. We used this technique to study mesenchymal stem cells and found that cells undergoing osteogenesis and adipogenesis exerted larger and more dynamic stresses than their precursor. Our results indicate that the MSCs develop the smallest forces and growth rates. We anticipate that simultaneous cell growth and traction measurements will improve our understanding of mechanotransduction, particularly during dynamic processes where the matrix properties provide context to guide cells towards a physiological or pathological outcome, e.g., tissue morphogenesis, or cancer metastasis.
Tracking Individual Differences in Perception by TMS-EEG Intrinsic Effective Connectivity
Authors: Mizuno Yuji , Kawasaki Masahiro , Shimono Masanori , Miniussi Carlo , Okazaki Yuka O , Ueno Kenichi , Suzuki Chisato , Asamizuya Takeshi , Cheng Kang , Kitajo Keiichi 
Published: October 2017

AbstractNon-invasive human electroencephalography (EEG) coupled with transcranial magnetic stimulation (TMS) is currently used to measure coarse stimulus-response relationships in brain physiology during behavior. However, with key modifications, the TMS-EEG technique holds even greater promise for monitoring fine-scale neural signatures of human behavior. Here, we demonstrate that a novel TMS-EEG co-registration technique can dynamically monitor individual human variation in perception based solely on EEG resting-state intrinsic effective connectivity probed by TMS-based phase resetting of ongoing activity. We used a bistable stimulus task, where the percept is perceived as either horizontal or vertical apparent motion, to record gamma band interhemispheric integration of information. Fine-grained inter-individual behavioral differences in horizontal motion bias could be measured by tracking resting-state gamma-band effective connectivity from right hMT+ to left hMT+. Thus, our method of triggering intrinsic resting-state effective connectivity in oscillatory dynamics can monitor individual differences in perception via the long-range integration of information. This technique will be useful for the manipulative dissection of individual-scale human cognition mediated by neural dynamics and may also expand neurofeedback approaches.
HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation
Authors: Kijima Toshiki , Prince Thomas L. , Tigue Megan L. , Yim Kendrick H. , Schwartz Harvey , Beebe Kristin , Lee Sunmin , Budzynski Marek A. , Williams Heinric , Trepel Jane B. , Sistonen Lea , Calderwood Stuart , Neckers Len 
Published: October 2017

AbstractHeat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress while also mediating a cancer-specific transcriptional program. HSF1 is thought to be regulated by molecular chaperones, including Heat Shock Protein 90 (HSP90). HSP90 is proposed to sequester HSF1 in unstressed cells, but visualization of this interaction in vivo requires protein crosslinking. In this report, we show that HSP90 binding to HSF1 depends on HSP90 conformation and is only readily visualized for the ATP-dependent, N-domain dimerized chaperone, a conformation only rarely sampled by mammalian HSP90. We have used this mutationally fixed conformation to map HSP90 binding sites on HSF1. Further, we show that ATP-competitive, N-domain targeted HSP90 inhibitors disrupt this interaction, resulting in the increased duration of HSF1 occupancy of the hsp70 promoter and significant prolongation of both the constitutive and heat-induced HSF1 transcriptional activity. While our data do not support a role for HSP90 in sequestering HSF1 monomers to suppress HSF1 transcriptional activity, our findings do identify a noncanonical role for HSP90 in providing dynamic modulation of HSF1 activity by participating in removal of HSF1 trimers from heat shock elements in DNA, thus terminating the heat shock response.
Coordinated morphogenesis through tension-induced planar polarity
Authors: Gillard Ghislain , Nicolle Ophélie , Brugières Thibault , Prigent Sylvain , Pinot Mathieu , Michaux Grégoire 
Published: October 2017

AbstractTissues from different developmental origins must interact to achieve coordinated morphogenesis at the level of a whole organism. C. elegans embryonic elongation is controlled by actomyosin dynamics which trigger cell shape changes in the epidermis and by muscle contractions, but how the two processes are coordinated is not known. We found that a tissue-wide tension generated by muscle contractions and relayed by tendon-like hemidesmosomes in the dorso-ventral epidermis is required to establish a planar polarity of the apical PAR module in the lateral epidermis. This planar polarized PAR module then controls actin planar organization, thus determining the orientation of cell shape changes and the elongation axis of the whole embryo. This trans-tissular mechanotransduction pathway thus contributes to coordinate the morphogenesis of three embryonic tissues.
Complex effects of day and night temperature fluctuations on thermally plastic traits in a seasonal plasticity model
Authors: Rodrigues Yara Katia , van Bergen Erik , Alves Filipa , Duneau David , Beldade Patrícia 
Published: October 2017

AbstractBackgroundChanges in development in response to seasonally variable environments can produce phenotypes adjusted to fluctuating seasonal conditions and help organisms cope with temporal heterogeneity. In contrast to what happens in natural situations, experimental studies of developmental plasticity typically use environmental factors held constant during development, precluding assessment of potential environment-by-environment interaction effects.ResultsWe tested effects of circadian fluctuations in temperature on a series of thermally plastic traits in a model of adaptive seasonal plasticity, the butterflyBicyclus anynana. Comparing phenotypes from individuals reared under two types of fluctuations (warmer days with cooler nights, and cooler days with warmer nights) and those reared under a constant temperature of the same daily average allowed us to identify complex patterns of response to day and night temperatures. We found evidence of additive-like effects (for body size), but also different types of “dominance”-type effects where one particular period of the light cycle (for development time) or one particular extreme temperature (for eyespot size) had a relatively larger contribution to phenotype expression. We also gathered evidence against the hypothesis that thermal plasticity in development time drives thermal plasticity in other traits.ConclusionsCombined effects of fluctuating day and night temperatures include additive-like effects as well as different types of environmental-dominance interaction effects. Differences between plastic traits reveal independent responses to temperature, and possible independent assessment of temperature conditions. Our study underscores the importance of understanding how organisms integrate complex environmental information towards a complete understanding of natural phenotypic variation and of the potential impact of environmental change thereon.
The glass ceiling: fact or a misguided metaphor?
Authors: Dowling Grahame 
Published: October 2017

PurposeThe glass ceiling is a metaphor used to characterize the gender inequality of women at the top in most large western organizations. This situation has prompted many business organizations, NGOs and governments to encourage large organizations to promote more women into the executive suite and onto boards of directors. While there is little controversy about this initiative, this paper argues that there should be because it directly challenges the principle that merit should outweigh diversity. The paper aims to discuss these issues.Design/methodology/approachThis paper reviews research that purports to show that women are unfairly under-represented in the most senior positions in large western organizations. It also reviews the arguments that more senior women would improve the performance of these organizations. This research is then used to develop a model of why there are markedly fewer women than men at the top of large organizations.FindingsThis study finds that most of the research studies purporting to show that there is a bias against promoting women to the top of large western organizations are unsound because they are poorly designed and/or fail to accommodate alternative explanations for this effect. Thus, the current number of women who run these organizations may be a good reflection of their contribution to the management of these organizations. These findings suggest that many of the policies that are promoted to help women break through the glass ceiling are misguided.Practical implicationsLarge organizations should think carefully about following the advice of special interest groups who vigorously promote this social cause.Social implicationsSocial policy advocates need better research from which to advance their cause that there are currently too few women in senior management positions of large organizations.Originality/valueThis is one of only a handful of papers that challenges the current orthodoxy that artificial glass ceilings are restricting the potential contribution of women to the better management of large organizations.
Employee well-being and turnover intention
Authors: Wu Weiwei , Rafiq Muhammad , Chin Tachia 
Published: October 2017

PurposeFacing a new round of global industrial restructuring, it is vital for less-developed yet populous regions to build a happy, engaged workforce to achieve competitiveness. The purpose of this paper is to integrate an indigenous cultural perspective, i.e. Muslim religious belief, with the job embeddedness theory to delve into employee well-being-turnover issues in a large developing country ingrained with Muslim culture.Design/methodology/approachThe authors conducted a questionnaire survey on employees from the media sector in the Muslim country, Pakistan. The data were analysed using moderated hierarchical regression models (investigating three-way interactions), while the significance tests of simple slopes and simple slope differences were also used to support the analysis.FindingsThe results suggest that all predictors analysed (Muslim religious belief, organisational embeddedness, life satisfaction, and work engagement) were negatively and significantly related to turnover intention. Furthermore, the employee well-being-turnover intention mechanisms are jointly moderated by Muslim religious belief and organisational embeddedness.Practical implicationsThe research considers turnover intention as an outcome of a three-way interaction among employee well-being, Muslim religious belief, and organisation embeddedness, thus proposing insightful implications for other developing country enterprises, particularly those ingrained with Muslim culture.Originality/valueThe authors propose a novel model which demonstrates the effects of employee work- and life-related well-being on turnover intention from a unique angle by incorporating Muslim religious belief with organisational embeddedness, contributing to the existing body of knowledge. The applicability of western concepts to immature markets is also examined.
Social value of an innovation ecosystem: the case of Leiden Bioscience Park, The Netherlands
Authors: Fulgencio Harry 
Published: October 2017

Purpose
Science parks are business clusters situated in a particular geographical location, originally conceptualized by local universities, local government and businesses. In recent times, science park stakeholders and tenants are starting to pursue social value and even how to manage. This study aims to clarify the understanding of social value in an innovation ecosystem.

Design/methodology/approach
This study combines existing literature studies and concepts, observations in a real-life innovation ecosystem – a Bioscience Park – and interviews of key personnel managing the science park.

Findings
Science Park Social Value (SPSV) is a value resulting from interaction among groups and not just the pursuit of a single firm-level goal. SPSV emanates from the firms within the science park in reaction to the demands of the actors or entities within and outside the innovation ecosystem of the science park: internal operations, external stakeholders and infexternal or broader societal impact. In addition to this, the author has conceptualized a framework for social value of an innovation ecosystem, which will require further research.

Research limitations/implications
This paper creates a link between concepts about social value, innovation ecosystem (e.g. science park) and stakeholder theory.

Practical implications
SPSV will be useful for science park orchestrators or managers to manage expectations of social and non-social actors.

Social implications
Social value of a science park will bring a new light on the stigma that science parks are only money-making ventures and are not in touch with social issues.

Originality value
This study theorized and researched previously unrelated concepts.
A capability framework to develop leadership for evidence-informed therapies in publicly-funded mental health services
Authors: Lau Geoffrey , Meredith Pamela , Bennett Sally , Crompton David , Dark Frances 
Published: October 2017

Purpose
It is difficult to replicate evidence-informed models of psychosocial and assertive care interventions in non-research settings, and means to determine workforce capability for psychosocial therapies have not been readily available. The purpose of this paper is to describe and provide a rationale for the Therapy Capability Framework (TCF) which aims to enhance access to, and quality of, evidence-informed practice for consumers of mental health services (MHSs) by strengthening workforce capabilities and leadership for psychosocial therapies.

Design/methodology/approach
Guided by literature regarding the inadequacies and inconsistencies of evidence-informed practice provided by publicly-funded MHSs, this descriptive paper details the TCF and its application to enhance leadership and provision of evidence-informed psychosocial therapies within multi-disciplinary teams.

Findings
The TCF affords both individual and strategic workforce development opportunities. Applying the TCF as a service-wide workforce strategy may assist publicly-funded mental health leaders, and other speciality health services, establish a culture that values leadership, efficiency, and evidence-informed practice.

Originality/value
This paper introduces the TCF as an innovation to assist publicly-funded mental health leaders to transform standard case management roles to provide more evidence-informed psychosocial therapies. This may have clinical and cost-effective outcomes for public MHSs, the consumers, carers, and family members.