bluuebunny/crossref_metadata_2025_split huggingface dataset:
An assessment of phylogenetic tools for analyzing the interplay between interspecific interactions and phenotypic evolution
Authors: Drury J.P. , G.F. Grether , Garland T. , Morlon H. 
Published: October 2016

AbstractMuch ecological and evolutionary theory predicts that interspecific interactions often drive phenotypic diversification and that species phenotypes in turn influence species interactions. Several phylogenetic comparative methods have been developed to assess the importance of such processes in nature; however, the statistical properties of these methods have gone largely untested. Focusing mainly on scenarios of competition between closely-related species, we assess the performance of available comparative approaches for analyzing the interplay between interspecific interactions and species phenotypes. We find that currently used statistical methods largely fail to detect the impact of interspecific interactions on trait evolution, that sister taxa analyses often erroneously detect character displacement where it does not exist, and that recently developed process-based models have more satisfactory statistical properties. In weighing the strengths and weaknesses of different approaches, we hope to provide a clear guide for empiricists testing hypotheses about the reciprocal effect of interspecific interactions and species phenotypes and to inspire further development of process-based models.
Lower brain pH as a shared endophenotype of psychotic disorders
Authors: Hagihara Hideo , Catts Vibeke S , Katayama Yuta , Takagi Tsuyoshi , Huang Freesia L , Huang Kuo-Ping , Ishii Shunsuke , Graef Isabella A , Crabtree Gerald R , Nakayama Keiichi I , Weickert Cynthia Shannon , Miyakawa Tsuyoshi 
Published: October 2016

AbstractLower pH is a well-replicated finding in the postmortem brains of patients with schizophrenia and bipolar disorder. Interpretation of the data, however, is controversial as to whether this finding reflects a primary feature of the diseases or is a result of confounding factors such as medication, postmortem interval, and agonal state. To date, systematic investigation of brain pH has not been undertaken using animal models, which can be studied without confounds inherent in human studies. In the present study, we first confirmed that the brains of patients with schizophrenia and bipolar disorder exhibit lower pH values by conducting a meta-analysis of existing datasets. We then utilized neurodevelopmental mouse models of psychiatric disorders in order to test the hypothesis that lower brain pH exists in these brains compared to controls due to the underlying pathophysiology of the disorders. We measured pH, lactate levels, and related metabolite levels in brain homogenates from three mouse models of schizophrenia (Schnurri-2KO, forebrain-specificcalcineurinKO, andneurograninKO mice) and one of bipolar disorder (Camk2aHKO mice), and one of autism spectrum disorders (Chd8HKO mice). All mice were drug-naïve with the same postmortem interval and agonal state at death. Upon postmortem examination, we observed significantly lower pH and higher lactate levels in the brains of model mice relative to controls. There was a significant negative correlation between pH and lactate levels. These results suggest that lower pH associated with increased lactate levels is a pathophysiology of such diseases rather than mere artifacts.
Inhibition of microbial biofuel production in drought stressed switchgrass hydrolysate
Authors: Ong Rebecca Garlock , Higbee Alan , Bottoms Scott , Dickinson Quinn , Xie Dan , Smith Scott A. , Serate Jose , Pohlmann Edward , Jones Arthur Daniel , Coon Joshua J. , Sato Trey K. , Sanford Gregg R. , Eilert Dustin , Oates Lawrence G. , Piotrowski Jeff S. , Bates Donna M. , Cavalier David , Zhang Yaoping 
Published: October 2016

AbstractBackgroundInterannual variability in precipitation, particularly drought, can affect lignocellulosic crop biomass yields and composition, and is expected to increase biofuel yield variability. However, the effect of precipitation on downstream fermentation processes has never been directly characterized. In order to investigate the impact of interannual climate variability on biofuel production, corn stover and switchgrass were collected during three years with significantly different precipitation profiles, representing a major drought year (2012) and two years with average precipitation for the entire season (2010 and 2013). All feedstocks were AFEX (ammonia fiber expansion)-pretreated, enzymatically hydrolyzed, and the hydrolysates separately fermented using xylose-utilizing strains ofSaccharomyces cerevisiaeandZymomonas mobilis.A chemical genomics approach was also used to evaluate the growth of yeast mutants in the hydrolysates.ResultsWhile most corn stover and switchgrass hydrolysates were readily fermented, growth of S.cerevisiaewas completely inhibited in hydrolysate generated from drought stressed switchgrass. Based on chemical genomics analysis, yeast strains deficient in genes related to protein trafficking within the cell were significantly more resistant to the drought year switchgrass hydrolysate. Detailed biomass and hydrolysate characterization revealed that switchgrass accumulated greater concentrations of soluble sugars in response to the drought and these sugars were subsequently degraded to pyrazines and imidazoles during ammonia-based pretreatment. When addedex situto normal switchgrass hydrolysate, imidazoles and pyrazines caused anaerobic growth inhibition ofS. cerevisiae.ConclusionsIn response to the osmotic pressures experienced during drought stress, plants accumulate soluble sugars that are susceptible to degradation during chemical pretreatments. For ammonia-based pretreatment these sugars degrade to imidazoles and pyrazines. These compounds contribute toS. cerevisiaegrowth inhibition in drought year switchgrass hydrolysate. This work discovered that variation in environmental conditions during the growth of bioenergy crops could have significant detrimental effects on fermentation organisms during biofuel production. These findings are relevant to regions where climate change is predicted to cause an increased incidence of drought and to marginal lands with poor water holding capacity, where fluctuations in soil moisture may trigger frequent drought stress response in lignocellulosic feedstocks.
Room with a view: how hedonic and utilitarian choice options of online travel agencies affect consumers’ booking intentions
Authors: Scholl-Grissemann Ursula , Schnurr Benedikt 
Published: October 2016

PurposeThe purpose of this study is to investigate how hedonic and utilitarian choice options of online travel agencies (OTAs) affect consumers’ process enjoyment and booking intentions.Design/methodology/approachThe authors apply a one-factorial experimental design. The stimuli consisted of screenshots of the fictitious OTA “www.my-holiday.com”. Participants were told to imagine they were planning a city trip to San Francisco and that, during an internet search, they came across a new OTA called “www.my-holiday.com”.FindingsThe authors find that both booking intentions and process enjoyment are higher for hedonic OTAs, i.e. OTAs which offer more hedonic choice options such as entertainment and spa. The authors conclude that these toolkits strongly relate to pleasurable experiences and positive emotions. Therefore, these options drive positive affective reactions in terms of process enjoyment, which subsequently affect booking intentions. Additionally, the authors find that preference insight positively affects consumers’ booking intention as the number of choices provided by the OTA increases.Originality/valueThis paper contributes to tourism research on online travel shopping behavior. The authors apply knowledge from research on online customization tools to an OTA context and show that hedonic and functional choice options of OTAs significantly reflect on consumer behavior.
The role of message strategies in promoting eco-friendly accommodations
Authors: Zanon Johanna , Teichmann Karin 
Published: October 2016

Purpose
This paper aims to examine how different levels of message appeals, message sources and social norms influence the purchase (i.e. booking) intention of eco-accommodations.

Design/methodology/approach
The proposed hypothesis was tested using a 2 (message appeal; rational vs emotional) × 2 (message source; expert vs blogger) × 2 (social norm; injunctive vs descriptive) between-subject experimental online design.

Findings
Advertising appeals and social norms are major predictors of eco-accommodation’s ad effectiveness and message appeals, sources and social norms, and their classifications interrelate with each other. The highest intention to purchase an eco-accommodation was found for a promotional message, which is sent by an expert, expresses a rational appeal and includes a descriptive social norm. Perceived emotional value in contrast was increased with a blogger statement including an emotional appeal and an injunctive social norm.

Research limitations/implications
The used experiment only focused on one product, namely, eco-friendly accommodations. The impacts of different message contents might vary as a function of the promoted product.

Practical implications
To develop persuasive messages which combine all three message contents, experts should craft messages with rational characteristics and address a descriptive social norm.

Originality/value
Although consumers show a desire to buy eco-friendly tourism products, it seems that supply actually overweighs demand. As research in the field of eco-accommodations is still limited, this study examines the role of different combined promotional message contents to further clarify the apparent gap in green consumption.
Advantages and limitations of community-based post-disaster housing reconstruction projects
Authors: Ophiyandri Taufika , Amaratunga Dilanthi , Keraminiyage Kaushal 
Published: October 2016

Purpose
The purpose of this paper is to discuss the advantages and limitations of the implementation of a community-based method in post-disaster housing reconstruction.

Design/methodology/approach
The research was based on multiple case studies in the implementation of a community-based post-disaster housing reconstruction project (CPHRP) in Indonesia. Data were gathered by conducting semi-structured interviews and a questionnaire survey.

Findings
The research reveals 22 advantages of a CPHRP. Four advantages can be categorised as highly significant. They are create sense of ownership, fit to local culture/customs/wisdom, build beneficiaries’ confidence and minimize corruption. There are some advantages that cannot be delivered if the housing reconstruction is conducted using a contractor-based approach. It was also found that psychological advantages are more dominant than the physical advantages. Despite its numerous advantages, CPHRP has limitations. First, it requires a long pre-construction process and, second, there is a limitation with regard to the capacity of implementer and there are limitations within the community itself.

Originality/value
This paper is very specific because it attempts to discover the advantages and limitations of a CPHRP.
Share resources through the largest interlibrary loan network
Authors: Burke Gemma , Duncan Erin , Smither JL 
Published: October 2016

Purpose
The paper aims to show how using a resource-sharing service can help you provide more resources to your users.

Design/methodology/approach
This paper discusses interlibrary loan challenges and opportunities, specifically with reference to WorldShare Interlibrary Loan.

Findings
This paper describes the service that connects libraries to the largest cooperative resource-sharing network with more than 10,000 borrowing and lending libraries worldwide, the possibilities for the future, facts and figures and how libraries around the world have used the solution successfully.

Originality/value
This paper looks at how WorldShare Interlibrary Loan can help libraries overcome the challenges that they face regarding resource sharing.
Open science: a revolution in sight?
Authors: Rentier Bernard 
Published: October 2016

PurposeThis paper aims to describe the evolution of scientific communication, largely represented by the publication process. It notes the disappearance of the traditional publication on paper and its progressive replacement by electronic publishing, a new paradigm implying radical changes in the whole mechanism. It aims also at warning the scientific community about the dangers of some new avenues and why, rather than subcontracting an essential part of its work, it must take back full control of its production.Design/methodology/approachThe paper reviews the emerging concepts in scholarly publication and aims to answer frequently asked questions concerning free access to scientific literature as well as to data, science and knowledge in general.FindingsThe paper provides new observations concerning the level of compliance to institutional open access mandates and the poor relevance of journal prestige for quality evaluation of research and researchers. The results of introducing an open access policy at the University of Liège are noted.Social implicationsOpen access is, for the first time in human history, an opportunity to provide free access to knowledge universally, regardless of either the wealth or the social status of the potentially interested readers. It is an essential breakthrough for developing countries.Originality/valueOpen access and Open Science in general must be considered as common values that should be shared freely. Free access to publicly generated knowledge should be explicitly included in universal human rights. There are still a number of obstacles hampering this goal, mostly the greed of intermediaries who persuade researchers to give their work for free, in exchange for prestige. The worldwide cause of Open Knowledge is thus a major universal issue for the twenty-first century.
Assessing the adoption and use of integrated library systems (ILS) for library service provision in academic libraries in Edo and Delta states, Nigeria
Authors: Omeluzor Saturday U. , Oyovwe-Tinuoye Gloria O. 
Published: October 2016

Purpose
The purpose of this study is to investigate the use of integrated library system (ILS) in academic library operations in Edo and Delta states, Nigeria.

Design/methodology/approach
This study adopted a descriptive survey research design. Total enumeration was used since the population consisting 88 academic librarians in Edo and Delta states is not large and was considered appropriate to achieve the purpose of this study. Questionnaire titled “Assessment of adoption and use of Integrated Library Software (ILS) for library service provision in academic libraries in Edo and Delta States, Nigeria” was used. Before the administration of the questionnaire on the respondents, face validity was carried out to test the validity of the questions. The questionnaire was given to experts in the Department of Information Resources Management, Babcock University, Ilishan-Remo, Ogun State who validated, resolved defects and modified the questionnaire.

Findings
This study showed that there is a general non-use of ILS in academic libraries in Delta state. Findings revealed that three of the four academic libraries in Edo State adopted library software in their library operations except Ambrose Ali University Library, Ekpoma. Findings further showed that the ILS that were used in academic libraries in Edo State are effective. It also revealed that ILS is effective for accessing books and other library materials, retrieval of materials, bibliographic search and provision of links to external databases. Finding also indicated that among the library software that were used in academic libraries in this study, only Koha ILS has the capacity to link to external databases.

Practical implications
The use of ILS in academic library operation is critical. Its adoption and use to a large extent positively affect the library and its users. Non-adoption and use of ILS in most academic libraries is a setback to delivery of quality library services to clientele.

Originality/value
This study is the first that assessed the adoption and use of ILS in academic libraries is Edo and Delta states. It exposed the level of adoption and utilization of ILS in library operations with a view to encouraging libraries to adopt and use ILS for library services.
Understanding academic reading in the context of information-seeking
Authors: Lopatovska Irene , Sessions Deanna 
Published: October 2016

Purpose
A study examined reading strategies in relation to information-seeking stages, tasks and reading media in an academic setting. Understanding reading practices and needs in the context of information-seeking can refine our understanding of user choices and preferences for information sources (e.g. textbooks, articles, multimedia content) and media (e.g. print and digital tools used for reading). It can also help to examine the changes in reading practices brought about by digital devices and content.

Design/methodology/approach
The data were collected via an online questionnaire from a sample of graduate students over the course of two months. The data were analysed using descriptive statistics.

Findings
The authors found that all information-seeking stages and all academic tasks were characterised by a combination of “deep” and “surface” reading and a use of both print and electronic resources. Contrary to previous studies that linked digital media to “surface” reading (e.g. skimming, searching for keywords), the participants reported a high number of “deep” reading tactics (e.g. annotating, connecting text to prior knowledge) while using digital resources.

Research limitations/implications
The study relied on a convenience sample of library and information science students, so some findings can be attributed to the sample’s demographics and academic demands. The findings imply that at all stages of information-seeking for all academic tasks, graduate students were engaged in both deep and surface reading using both print and electronic resources.

Practical implications
The findings show that students read print and digital texts, suggesting that it might be premature for academic libraries to part with their print collections. Understanding relationships between academic task, information-seeking and reading can aid students in choosing the right reading resources for their academic tasks, educators in assigning appropriate materials for course projects, libraries in providing appropriate resources to their readers and information retrieval system designers in offering useful features for different reading needs and styles.

Social implications
The findings indicate a shift in academic work culture and reliance on digital texts for deep and surface reading.

Originality/value
The study produced preliminary support for the development of a unified information-seeking and reading model.
Usefulness of serum 5‐S‐cysteinyl‐dopa as a biomarker for predicting prognosis and detecting relapse in patients with advanced stage malignant melanoma
Authors: Umemura Hiroshi , Yamasaki Osamu , Kaji Tatsuya , Otsuka Masaki , Asagoe Kenji , Takata Minoru , Iwatsuki Keiji 
Published: October 2016

AbstractWith the recent development of novel molecular targeted drugs for advanced stage malignant melanoma (MM), including RAF and mitogen‐activated protein kinase kinase inhibitors and immune checkpoint blockers, the early detection of relapse is important for managing patients with MM. In this study, we retrospectively analyzed two conventional serum biomarkers, 5‐S‐cysteinyl‐dopa and lactate dehydrogenase, in patients with MM (n = 140) who were treated at a single Japanese institute from June 2007 to June 2015. At the initial hospital visit, serum 5‐S‐cysteinyl‐dopa levels were significantly increased in patients with stages III (n = 38) and IV (n = 20) MM compared with patients with stages 0–II (n = 62) MM. In addition, in patients with stages III and IV MM, serum 5‐S‐cysteinyl‐dopa levels of more than 15.0 nmol/L at initial hospital visit correlated with a poor prognosis. In 11 of 14 patients whose disease progressed during follow up (mostly from stages III–IV), serum 5‐S‐cysteinyl‐dopa levels exceeded the normal limit of 10.0 nmol/L during the clinical detection of distant metastases. These results indicate the usefulness of measuring serum 5‐S‐cysteinyl‐dopa levels at initial hospital visit and during follow up for early and effective therapeutic interventions using newly developed molecular targeted drugs.
One‐stop thyroid nodule clinic with same‐day fine‐needle aspiration cytology improves efficiency of care
Authors: Patel Rajeshbhai , R. Skandarajah Anita , Gorelik Alexandra , Shears Matthew J. , Tasevski Robert , Miller Julie A. 
Published: October 2016

BackgroundThyroid nodules are a common presenting complaint for endocrine surgeons; many require ultrasound‐guided fine‐needle aspiration cytology (US‐FNAC). In an attempt to streamline our service, we introduced same‐day surgeon‐performed US‐FNAC in 2014.MethodsThree groups were defined: (A) retrospective group with FNAC performed in radiology prior to August 2014; (B) prospective radiology FNAC group; and (C) prospective surgeon‐performed group. Demographics, nodule characteristics, pathology and management plans were recorded. The number and dates of hospital attendances were extracted from the patient information system.ResultsOver 4 years, 635 patients underwent 757 FNACs. There were 438 patients in group A, 78 in group B and 119 in group C. Patient demographics and nodule size were similar between groups. Those patients undergoing FNAC in endocrine surgery clinic required two visits prior to receiving a diagnosis and management plan, compared with three visits for those performed in radiology. Non‐diagnostic rates between three groups were 6.5%, 7.4% and 5.4% (P = 0.842) whilst malignant FNAC results occurred in 3%, 4% and 8% (P = 0.015) respectively. Median time from US‐FNAC to definitive management plan was 42, 41 and 14 days (P < 0.001). The introduction of the one‐stop clinic resulted in a 41% reduction of patients attending the radiology department for FNAC.ConclusionSurgeon‐performed US‐FNAC decreases the time from fine‐needle aspiration request to definitive plan and reduces the number of patient visits, providing more efficient care. Patients referred to the endocrine surgery clinic with thyroid nodules have thyroid cancer more frequently than patients referred to radiology.