bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between residual cholesterol and cognitive performance: a study based on NHANES
Authors: Liu Kepeng , Fu Haishou , Chen Yong , Li Binfei , Huang Huaqing , Liao Xiaozu 
Published: September 2024

Background and aimsAge-related cognitive impairment impacts a significant portion of the elderly population. Remnant cholesterol (RC) has attracted increased attention in relation to cardiovascular disease, diabetes, hypertension, and fatty liver disease. Nevertheless, its role in cognitive function is still enigmatic, prompting our exploration into the potential associations between them.MethodsA total of 1,331 participants from the NHANES (2011–2014) database, all aged over 60, were included in this investigation. Cognitive function was assessed using four widely applied tests, including the Consortium to Establish a Registry for Alzheimer’s Disease Word Learning (CERAD-WL), CERAD Delayed Recall (CERAD-DR), Animal Fluency Test (AFT), as well as Digit Symbol Substitution test (DSST). Z-score is calculated by scores from the above four tests. The association between RC, total cholesterol (TC) to RC and cognitive performance was assessed by logistic regression analyses. In addition, restricted cubic spline (RCS) regression was performed to assess non-linearity between RC and cognitive function. Subgroup analysis was performed to evaluate the robustness of the results in populations with relevant covariate variables.ResultsThose with Z-scores below the 25% quartile are defined as having cognitive impairment, totaling 498 individuals. Observationally, higher RC levels and a lower TC/RC were associated with an increased risk of cognitive impairment. After adjusting for confounding factors, the impact of RC levels on cognitive performance quartiles was consistent across various subgroups, except in individuals with trouble sleeping, no/unknown alcohol use, and no hypertension. Americans with high RC levels and trouble sleeping are more likely to develop cognitive impairment, with an odds ratio of 2.33 (95% CI: 1.18–4.59).ConclusionThis study suggests that higher RC levels and lower levels of TC/RC are associated with an increased likelihood of cognitive impairment, suggesting that RC can serve as a novel and convenient indicator for predicting the risk of cognitive impairment in the US population.
Comparative study of CAD/CAM reconstruction and miniplates for patient-specific fixation in LCL-type mandibular reconstruction
Authors: Lampert Philipp , Fenske Jakob , Wüster Jonas , Koerdt Steffen , Kreutzer Kilian , Ruf Philipp , Checa Sara , Heiland Max , Steffen Claudius , Rendenbach Carsten 
Published: September 2024

ObjectiveMiniplates offer superior clinical handling and facilitate postoperative removal after mandibular reconstruction but unfavorable load distribution under high stress has been shown. This study aimed to compare the clinical outcome of patient-specific 3D-printed (PS-3D) titanium miniplate with reconstruction plate fixation in three-segmental LCL-type reconstructions for the first time.MethodsPatients undergoing three-segmental LCL-type mandibular reconstruction after malignant tumor resection between April 2017 and July 2023 were analyzed in a retrospective single-center study. Inclusion criteria were primary reconstruction using a fibula free flap and PS-3D titanium mini- or reconstruction plate fixation. Complication rates were recorded and analyzed within 6 months after surgery using the N – 1 Chi2- and unequal variance t-test.Results38 patients (10 females, 28 males; mean age 61.4 ± 7.6 years) met the inclusion criteria. In 14 patients (36.8%) miniplates were used in the anterior region. Rates of fixation failure, plate exposure, incomplete osseous union, wound infection, soft tissue, and overall complications did not differ significantly between the two plate systems.ConclusionComplication rates did not differ significantly between PS-3D mini- and reconstruction plates in three-segmental LCL-type mandibular reconstructions. Given their advantages in clinical handling and postoperative removal, PS-3D miniplates can be a viable alternative also in larger mandibular reconstructions.
Rosa × damascena Herrm. essential oil: anti-tyrosinase activity and phytochemical composition
Authors: Wu Qiuyan , Fang Wanting , Liu Hao , Liu Zhong , Xu Xuetao 
Published: September 2024

Tyrosinase is a key enzyme in melanin synthesis, and its natural inhibitors are receiving increasing attention. Rosa × damascena Herrm. essential oil (RDEO), as important functional metabolites, was widely known due to its biological activities. But its tyrosinase inhibitory activity has not been detailed investigated. Therefore, in this paper, RDEO was comprehensively investigated the tyrosinase inhibitory, followed by the phytochemical composition analysis. Activity screening results showed that RDEO exhibited effective anti-tyrosinase activity and was a reversible and mixed-type inhibitor. CD assay results revealed that RDEO could affect the conformation of tyrosinase to reduce the activity. In B16F10 cells, RDEO (25–100 μg/mL) could inhibit intracellular tyrosinase activity and decrease melanin content. Finally, GC-MS analysis of RDEO found that citronellol (21.22%), geraniol (14.1%), eicosane (11.03%), heneicosane (6.65%) and 1-nonadecene (5.16%) were its main phytochemical compositions. This study provided data support for Rosa × damascena Herrm. essential oil as one potential natural tyrosinase inhibitor and its applications in cosmetics and medicine.
A single intraarticular injection of a tranexamic acid-modified hyaluronic acid (HA/TXA) alleviates pain and reduces OA development in a murine model of monosodium iodoacetate-induced osteoarthritis
Authors: Brochard Sybille , Boumédiene Karim , Mercier Jéromine , Agin Véronique , Conrozier Thierry , Baugé Catherine 
Published: September 2024

RationaleTranexamic acid (TXA) is a strong and specific plasminogen activator inhibitor with inhibitory effects on the matrix metalloproteases involved in the pathophysiology of osteoarthritis (OA) through targeting of the fibrinolysis pathway. In this study, we evaluated the analgesic and chondroprotective effects of a HA-tranexamic acid (HA/TXA) conjugate, compared to HA alone and placebo, in an animal model of knee OA.MethodsKnee OA was induced in 15 C57 b l/6J mice by IA injection of 0.75 mg of Monosodium IodoAcetate (MIA). At day 28, the mice received 1 IA injection of 10 µL of saline (control-group), or of HA or of HA/TXA. Tactile sensitivity was assessed using von Frey filaments. Stimulations started at 1 g and increased until a response was obtained (up to 4 g). A response to the stimulus was counted if the animal withdrew its paw. If the animal responded to the 1 g stimulation, stimulation was reduced until the lack of response was observed (up to 0.2 g). At day 56, mice were euthanized for knee histological assessment. Cartilage degradation was assessed using the OARSI score. Statistical analysis was performed on GraphPad Prism 8.0.2 software. Kruskal–Wallis or Mann-Whitney tests were performed as appropriate.ResultsJust before treatment administration, no intergroup difference in paw withdrawal threshold was observed. Throughout the experiment animals given saline and HA had a lower paw withdrawal threshold than those treated with HA/TXA (p &lt; 0.01). In the control group OARSI score was 5.5 ± 0.6. In HA and HA + TXA treated mice the OARSI score was 3.2 ± 0.8 and 3.1 ± 0.5 (p &lt; 0.01) showing that both treatments were able to reduce OA progression.ConclusionIn this animal model of MIA induced KOA, a single IA injection of a HA/TXA conjugate resulted in a greater efficacy on pain than both saline and HA. HA and HA/TXA exhibited chondroprotective effects compared to placebo.
Family language policy retention across generations: childhood language policies, multilingualism experiences, and future language policies in multilingual emerging Canadian adults
Authors: Pagé Leah L. , Noels Kimberly A. 
Published: September 2024

IntroductionLanguage policies in multilingual families refer to parents’ decisions, whether explicitly articulated or not, regarding which languages will be used in which contexts. However, because most studies that explore language allocation focus on families with young children, they do not address how family language policies impact the retention of a home language through to the next generation. The present study investigates an important perspective on this issue, specifically how emerging adults’ childhood experiences with their family language policy relate to the languages they currently use and plan to retain in the future.MethodsIn all, 62 multilingual Canadian adults, aged between 17 and 29 years, participated in focus group interviews concerning their experience of language policies in their birth families, their current beliefs concerning language allocation and retention, and their plans about language policy in their future families.ResultsThe data revealed that not only are most participants interested in retaining their home language, thereby continuing to speak the language in their future families, but most are also open to incorporating additional languages into their policies.DiscussionThe results provide insight into how to identify effective heritage language retention policies that transcend generations.
Substance use among young people in sub-Saharan Africa: a systematic review and meta-analysis
Authors: Ebrahim Jemal , Adams Jon , Demant Daniel 
Published: September 2024

BackgroundThe use of substances such as alcohol, tobacco, khat, or drugs among young people is becoming a public health concern globally, with particularly high prevalence rates in low and middle-income settings, where socio-cultural and economic factors contribute to distinct challenges in addressing this problem. This review aimed to summarize the current literature on the prevalence of substance use among young people in sub-Saharan Africa (SSA) and identify gaps in the current body of literature.MethodsSeven databases and Google were searched for studies reporting on substance use prevalence among young people (aged 10-24 years) in SSA, published between January 2010 and May 2024. Observational studies were included, assessed for methodological quality, and checked for the presence of heterogeneity and publication bias using standard methods. A random effect model was used to estimate the pooled proportions for substance use among young people.ResultsThe literature search identified 1,889 hits from the databases and Google. Among these 60 eligible studies involving 83,859 respondents were included in the review. The overall lifetime, 12-month, and current prevalence of any substance use among young people in SSA was found to be 21.0% (95% CI= 18.0, 24.0), 18% (95% CI=10,27), and 15% (95% CI=12,18), respectively. Among young people from SSA, alcohol use problem was the most prevalent (40%), followed by khat use (25%), stimulant use (20%), and cigarette smoking (16%). Other substances used by a smaller proportion of young people included cannabis, cocaine, inhalants, sedatives, shisha, hallucinogens, steroids, and mastics. The prevalence of substance use problems was higher among males compared to females, highest in the southern African region followed by Western and Eastern regions, and in community-based studies compared to institutional-based studies.ConclusionsIn SSA, over a fourth of young people use at least one substance in their lifetime, with higher rates among males than females and in community-based compared to institution-based studies. These results emphasize the need for interventions targeting the wider young population and those in specific subgroups identified as being at higher risk of substance use. This approach allows for the provision of tailored support and resources to those who need it most while also promoting positive health outcomes for the entire population of young people in the region.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022366774, identifier CRD42022366774.
PENGARUH PERBEDAAN LUAS PERMUKAAN LUBANG FILTRASI ALAT PENJERNIH AIR BIO-MULTIFILTER TERHADAP pH DAN TDS
Authors: Nindito Dwi Anung , Radha'ah Fatimatur , Jaya Allan Restu 
Published: September 2024

Pertumbuhan penduduk berdampak pada kebutuhan air bersih, baik secara kualitas, kuantitas maupun kontinuitas. Permasalahan air baku di permukiman sekitar lahan gambut yang tidak terjangkau PDAM adalah kandungan keasaman dan tingkat kekeruhan air yang tinggi akibat sedimentasi sungai. Berdasarkan permasalahan tersebut diperlukan Teknologi Tepat Guna (TTG) pengolah air dengan sistem sederhana yang bisa diterapkan di masyarakat perdesaan, antara lain penjernih air berjenis filtrasi. Penelitian ini bertujuan untuk mendesain alat penjernih air berjenis filtrasi (multifilter) dengan memvariasi luas permukaan lubang filtrasi, sehingga diketahui seberapa besar pengaruhnya terhadap parameter keasaman (pH) dan Total Dissolved Solids (TDS). Metode eksperimental dilakukan menggunakan penjernih air bio-multifilter dengan memvariasi luas permukaan filtrasi yang berbeda, yaitu 25%, 50% dan 75% terhadap luas permukaan total. Dimensi penjernih air berukuran 2R/3, R dan 4R/3, dengan R adalah jari-jari ketebalan lapis filtrasi. Media filter yang digunakan adalah karang jahe, batu zeolit dan bio filter serat ijuk yang diujikan dengan kerapatan media filter yang konstan. Hasil pengujian menunjukkan bahwa penjernih air bio-multifilter yang paling optimal dalam menaikkan derajat keasaman (pH) adalah penjernih air berukuran jari-jari 4R/3 yang memiliki luas permukaan lubang filtrasi sebesar 75%, dengan kenaikan sebesar 36,28%. Penjernih air berukuran jari-jari 2R/3 yang memiliki luas permukaan lubang filtrasi sebesar 50% mampu menstabilkan nilai TDS, dengan kenaikan kadar TDS sebesar 11,11%. Luas permukaan lubang filtrasi memengaruhi kinerja alat penjernih air bio-multifilter untuk menaikkan pH dan menstabilkan TDS.
Kata kunci : TDS, pH, Filtrasi, Penjernih Air
Effects of Methods of Planting and Time of Herbicide Application on the Economic of Lowland Rice in Badeggi, Nigeria
Authors: Audu S.D , Haruna I.M , Ibrahim A. J , Ibrahim S. O , Bakare S. O 
Published: September 2024

The experiment was conducted in 2021 and 2022 wet season at National Cereals Research Institute headquarters, Badeggi, Niger state (latitude 9o041 02.05’’N, longitude 0.6o011 3.31’’E) in the Southern Guinea Savannah Agro-Ecological Zone of Nigeria. To evaluate the cost-effectiveness of different planting methods and herbicide application timings on lowland rice production for farmers in the region. The experiment was laid out in a factorial experiment. The treatment consists of five sowing methods (broadcasting dry, broadcasting wet, dibbling wet, dibbling dry and transplanting) with two different timing of herbicide application. The 10 treatment combinations were laid out in a factorial experiment with a split-plot design with timing of herbicide application allocated to the main plot while sowing methods were designated to the sub-plot. Data were collected on Plant height, number of tillers, day to 50% flowering, day to maturity, number of seeds per panicle, seed yield per panicle, 1000-grain weight and grain yield per hectare. The result indicated that overall, the transplanting method of planting resulted in the significantly highest for all parameters, followed by the dibbling wet and dibbling dry methods. The broadcast method resulted in the poorest outcomes. Applying herbicide at 2 WAS resulted in better outcomes compared to 3 WAS. The transplanting method with herbicide application at 2 WAS resulted in the significantly highest grain yield, gross returns, and gross margin, making it the most profitable option.
Pengaruh Current Ratio, Debt to Equity Ratio dan Net Profit Margin Terhadap Harga Saham
Authors: Amirullah Ade , Andar Febyansyah  
Published: September 2024

Abstract
The purpose of this research is to examine the influence of the Current Ratio, Debt to Equity Ratio, and Net Profit Margin on the Stock Prices of coal mining companies listed on the Indonesia Stock Exchange during the 2021-2023 period. This study uses a causal associative research design with secondary data. The sampling technique employed is purposive sampling, resulting in a sample of 19 companies that meet the criteria from the population, covering a research period of 3 years, thus yielding 57 sample data points. This study utilizes a multiple linear regression analysis model. The results of the research indicate that the Current Ratio has no effect on Stock Prices, the Debt to Equity Ratio has a negative effect on Stock Prices, and the Net Profit Margin has a positive effect on Stock Prices. Future researchers are encouraged to consider or include other variables that may affect Stock Prices, such as Sales Growth, Leverage, Dividend Policy, Inflation Rate, Interest Rate, and the Indonesian Coal Index (HBA) on different research objects. The factor of Net Profit Margin can be used as a key reference for companies in efforts to increase their Stock Prices.

Abstrak
Tujuan penelitian ini untuk mengetahui pengaruh Current Ratio, Debt to Equity Ratio dan Net Profit Margin terhadap Harga Saham sektor pertambangan batubara yang terdaftar di Bursa Efek Indonesia periode 2021-2023. Pelaksanaan penelitian ini menggunakan desain penelitian asosiatif kausalitas dengan jenis data sekunder. Teknik pengambilan sampel menggunakan purposive sampling dan diperoleh sebanyak 19 perusahaan yang memenuhi kriteria dari jumlah populasi dengan periode penelitian 3 tahun, sehingga diperoleh sebanyak 57 data sampel. Penelitian ini memanfaatkan model analisis regresi linear berganda. Hasil penelitian menunjukkan Current Ratio tidak berpengaruh terhadap Harga Saham, Debt to Equity Ratio berpengaruh negatif terhadap Harga Saham dan Net Profit Margin berpengaruh positif terhadap Harga Saham. Peneliti selanjutnya diharapkan dapat mempertimbangkan atau menambah variabel-variabel lain yang dapat mempengaruhi Harga Saham seperti, Pertumbuhan Penjualan, Leverage, Kebijakan Dividen, Tingkat Inflasi, Tingkat Suku Bunga dan HBA pada objek penelitian yang berbeda. Faktor dari Net Profit Margin dapat dijadikan acuan utama bagi perusahaan dalam upaya untuk meningkatkan Harga Saham perusahaan.
ANALYSIS OF INTEREST IN SAVING IN SHARIA BANK AMONG FEBI STUDENTS OF UIN SMH BANTEN
Authors: M Shiffa Aida , A Athiyya Rizky , Azahra Luvita , Saraswati Henny , Hidayat Wahyu 
Published: September 2024

This study aims to find out the students of UIN SMH Banten in Islamic Banks. Questionnaires were distributed to 32 FEBI students at UIN SMH Banten, Serang City. The collected data were analyzed using descriptive and inferential statistics. Based on the data obtained, it is known that the variables of bank reputation and beliefs influence the interest in saving for UIN SMH Banten students in Islamic banks. The purpose of this study is to analyze the interest of FEBI students at UIN SMH Banten in saving at Islamic banks. This research is quantitative descriptive research using primary data. The variables used in this study consist of bank reputation and trust as independent variables and interest in saving students as the dependent variable. The data collection method uses by providing questionnaires. The method used in this research is descriptive analysis.The results of the study show that the difference between men and interest in savings in Islamic banks is significantly different.
Keywords: Analysis, Interest in Saving, Islamic Banks, FEBI Students
A linguistic Study of Pleonasm in Samuel Beckett's the endgame
Authors: Farooq Lina salam 
Published: September 2024

الاطناب هي كلمة غير ذات صلة أو لا داعي لها و تؤدي إلى تكرار ما قيل بالفعل. وفقًا لكروز (2000: 223)، "تحدث العلاقة المتضخمة للأطناب بين عنصرين عندما يبدو أحدهما زائدًا عن الحاجة، ولا تضيف شيئًا سوى المعلومات الدلالية التي قدمها العنصر الآخر بالفعل". في التفاعل اليومي وكذلك الكتابة، والاستعمال الاقتصادي للكلمات ليس دائمًا ما نطلبه.
هدفت هذه الدراسة إلى التعرف على أنواع الاطناب ووظائفها البلاغية في إطار الدراما. وأظهرت النتائج أن الإطالة التي هي نوع من الاطناب، هي الأكثر استعمالا .ومن ناحية أخرى فإن الضمائر التوكيدية المتعددة والضمائر الانعكاسية التوكيدية التي هي أنواع من الاطناب النحوي تقرأ (صفر).وأن الوظيفة البلاغية المهيمنة في الاطناب هي التوكيد والوضوح وهو الأقل منها.
Gold Investment Decisions to Anticipate Various Economic Problems in the Future (Study of Generation Z Mothers in Makassar City)
Authors: Msi Rustan 
Published: September 2024

This type of qualitative research uses a phenomenological approach. The results of the research show that women, especially housewives, see the potential of gold as a very important investment, with the concept of understanding that gold investment cannot be separated from the risks and principles of benefits obtained, consistency in investment, gold that reliable, and following market developments. With awareness of the importance of gold investment and ongoing financial education, housewives can build a strong foundation for family financial stability, maintain peace of mind in the face of an uncertain future, and provide a solid foundation for future generations.

Received: 23 July 2024 / Accepted: 31 August 2024 / Published: 7 September 2024
Gambaran Hasil Procalcitonin dan D-Dimer Pada Pasien Covid-19 Di RSUD Budhi Asih Jakarta Timur
Authors: Permata Kamilia Gulin , Nurdiani Catu Umirestu , Nugroho Heru Purwanto , Susanti Ellis 
Published: September 2024

The World Health Organization (WHO) declared an epidemic caused by Coronavirus Disease – 19 (Covid-19) on January 9, 2020. The first case was found on December 30, 2019 in Wuhan, China. The virus spreads through droplets. Symptoms of COVID-19 start from shortness of breath, cough and fever. Patients who are confirmed with COVID-19 are then carried out laboratory tests in the form of Procalcitonin (PCT) and D-dimer. This study was conducted using a descriptive method whose data was taken from laboratory examination results for the period April 2022 - May 2023 as many as 54 PCT and D-dimer result data. The results of the frequency distribution examination were based on normal values, normal PCT levels as many as 24 patients (44%) and abnormal PCT levels as many as 30 patients (56%) and normal D-dimer levels as many as 23 patients (43%) and abnormal D-dimer levels as many as 31 patients (57%). The frequency distribution in COVID-19 patients based on gender, male as many as 28 patients (52%) while in women as many as 26 patients (48%).In this conclusion, the frequency distribution of PCT and D-dimer examinations based on gender, men are higher than women. PCT examination is more with abnormal values compared to normal values. D-dimer test results with abnormal values more than normal values.
Keyword : Covid-19, D-dimer, PCT