bluuebunny/crossref_metadata_2025_split huggingface dataset:
CHUP1 restricts chloroplast movement and effector‐triggered immunity in epidermal cells
Authors: Nedo Alexander O. , Liang Huining , Sriram Jaya , Razzak Md Abdur , Lee Jung‐Youn , Kambhamettu Chandra , Dinesh‐Kumar Savithramma P. , Caplan Jeffrey L. 
Published: October 2024

Summary

Chloroplast Unusual Positioning 1 (CHUP1) plays an important role in the chloroplast avoidance and accumulation responses in mesophyll cells. In epidermal cells, prior research showed silencing CHUP1‐induced chloroplast stromules and amplified effector‐triggered immunity (ETI); however, the underlying mechanisms remain largely unknown.

CHUP1 has a dual function in anchoring chloroplasts and recruiting chloroplast‐associated actin (cp‐actin) filaments for blue light‐induced movement. To determine which function is critical for ETI, we developed an approach to quantify chloroplast anchoring and movement in epidermal cells. Our data show that silencing NbCHUP1 in Nicotiana benthamiana plants increased epidermal chloroplast de‐anchoring and basal movement but did not fully disrupt blue light‐induced chloroplast movement.

Silencing NbCHUP1 auto‐activated epidermal chloroplast defense (ECD) responses including stromule formation, perinuclear chloroplast clustering, the epidermal chloroplast response (ECR), and the chloroplast reactive oxygen species (ROS), hydrogen peroxide (H2O2). These findings show chloroplast anchoring restricts a multifaceted ECD response.

Our results also show that the accumulated chloroplastic H2O2 in NbCHUP1‐silenced plants was not required for the increased basal epidermal chloroplast movement but was essential for increased stromules and enhanced ETI. This finding indicates that chloroplast de‐anchoring and H2O2 play separate but essential roles during ETI.
The Role of Autophagy on Osteogenesis of Dental Follicle Cells Under Inflammatory Microenvironment
Authors: Jiang Zhen , Huang Haiyan , Luo Linjuan , Jiang Beizhan 
Published: October 2024

ABSTRACTObjectiveThis study investigated the role of autophagy on osteogenesis of DFCs under inflammatory microenvironment during tooth eruption.MethodsDFCs were isolated and identified. Lipopolysaccharide (LPS) was used to construct the inflammatory microenvironment in vitro and in vivo. Cell viability was examined by CCK‐8 assay. Osteogenic differentiation was evaluated by alkaline phosphatase (ALP) staining, alizarin red S (ARS) staining. The gene and protein levels were examined using qRT‐PCR and western blot analysis, respectively. We observed the process of tooth eruption after local LPS injection by micro‐CT and HE staining. Osteogenesis and autophagy were monitored through qRT‐PCR, western blot and histological staining of specific markers.ResultsLPS at the indicated concentrations did not produce toxic effects on DFCs, and significantly promoted the inflammatory gene expression. LPS inhibited osteogenic differentiation and activated autophagy in DFCs. Blocking autophagy with 3‐MA reversed the expression of osteogenic markers in LPS‐treated DFCs. Additionally, the eruption of LPS‐treated teeth was accelerated and their DFs exhibited an increased expression of TNF‐α and Beclin1, and decreased expression of ALP and RUNX2.ConclusionsAutophagy was involved in the suppression of the DFCs osteogenesis in an LPS‐induced inflammatory condition, suggesting the pivotal role of autophagy in inflammation‐induced premature tooth eruption.
Oral Manifestations in Paraneoplastic Syndromes: A Systematic Review and Meta‐Analysis
Authors: Messina Sabrina , De Falco Domenico , Petruzzi Massimo 
Published: October 2024

ABSTRACTObjectiveThis study examined the prevalence of oral signs and symptoms in paraneoplastic syndromes.Materials and MethodsA systematic search on oral paraneoplastic syndromes was conducted in MEDLINE/PubMed, Ovid, and Scopus databases from inception to April 1, 2024. Risk of bias was evaluated using the MURAD or Quality in Prognosis Studies tools, and a random‐effects meta‐analysis was performed. Evidence quality was rated using the GRADE approach.ResultsThe study sample comprised 811 participants from 487 studies. Oral manifestations predominantly affected patients with paraneoplastic pemphigus, mucous membrane pemphigoid, and acanthosis nigricans. Palate is the most frequently affected site (18.2%; 95% confidence interval [CI] 14.7–21.9), while erosion was the most common lesion type (83.3%; 95% CI 72.2–92.0) associated with the underlying malignancy. The prevalence of death in people with paraneoplastic syndromes was 50.9% (95% CI 39.9–61.7), while the prevalence of remission after neoplasm treatment was 63.4% (95% CI 49.9–76.0). GRADE assessment revealed uniformly low to very low certainty for all outcomes studied.ConclusionsFurther research is needed to understand the mechanisms behind these oral manifestations, which is crucial for earlier paraneoplastic syndrome diagnosis and optimal patient management.Trial RegistrationPROSPERO number: CRD42022328921
Genetic and Environmental Patterns Underlying Phenotypic Plasticity in Flowering Time and Plant Height in Sorghum
Authors: Wei Jialu , Guo Tingting , Mu Qi , Alladassi Boris M.E. , Mural Ravi V. , Boyles Richard E. , Hoffmann Leo , Hayes Chad M. , Sigmon Brandi , Thompson Addie M. , Salas‐Fernandez Maria G. , Rooney William L. , Kresovich Stephen , Schnable James C. , Li Xianran , Yu Jianming 
Published: October 2024

ABSTRACTPhenotypic plasticity is the property of a genotype to produce different phenotypes under different environmental conditions. Understanding genetic and environmental factors behind phenotypic plasticity helps answer some longstanding biology questions and improve phenotype prediction. In this study, we investigated the phenotypic plasticity of flowering time and plant height with a set of diverse sorghum lines evaluated across 14 natural field environments. An environmental index was identified to quantitatively connect the environments. Reaction norms were then obtained with the identified indices for genetic dissection of phenotypic plasticity and performance prediction. Genome‐wide association studies (GWAS) detected different sets of loci for reaction‐norm parameters (intercept and slope), including 10 new genomic regions in addition to known maturity (Ma1) and dwarfing genes (Dw1, Dw2, Dw3, Dw4 and qHT7.1). Cross‐validations under multiple scenarios showed promising results in predicting diverse germplasm in dynamic environments. Additional experiments conducted at four new environments, including one from a site outside of the geographical region of the initial environments, further validated the predictions. Our findings indicate that identifying the environmental index enriches our understanding of gene‐environmental interplay underlying phenotypic plasticity, and that genomic prediction with the environmental dimension facilitates prediction‐guided breeding for future environments.
Success rate and predictors of failure of enema reduction of intussusception in children with a water‐soluble contrast medium at a height of 120 cm or less
Authors: Yatabe Reiko , Kishibe Shun , Akahoshi Shogo , Shimojima Naoki , Sakakibara Hiroshi 
Published: October 2024

AbstractBackgroundThis study investigates the reduction rate and failure predictors of hydrostatic enema reduction for intussusception. The procedure typically begins with a water‐soluble contrast medium at 90 cm above the patient, subsequently elevated to 120 cm. Our focus is on the reduction rate during initial attempts when the contrast medium is positioned at or below 120 cm from the patient.MethodsHydrostatic enema reductions for intussusception, performed between March 2010 and May 2022 at Tokyo Metropolitan Children's Medical Center, were investigated retrospectively. The initial attempts involved one or more trials. The clinical characteristics, treatment modalities, and outcomes were analyzed. Logistic regression was used to identify the predictors of failure when the reduction was performed with the water‐soluble contrast medium at a height of 120 cm or less.ResultsReduction was achieved successfully with the water‐soluble contrast medium at a height at or below 120 cm in 77.5% of 351 patients. When reductions performed at heights greater than 120 cm were included, 333 (94.9%) were successful during the initial attempts and were unaccompanied by complications. Predictors of failure of reductions performed at or below 120 cm were age less than 12 months and the presence of trapped fluid.ConclusionThe present study found a successful reduction rate of 77.5% during the initial attempts, suggesting that a height greater than 120 cm may yield an even greater success rate. Children aged below 12 months and those with trapped fluid may have a greater failure risk during the initial attempts.
Orthodontic management of uneven gingival margins in patients with healthy or reduced periodontium to improve smile aesthetics
Authors: Martin Conchita , Papageorgiou Spyridon N. , Gonzalez‐Martin Oscar , Sanz Mariano 
Published: October 2024

AbstractUneven gingival margins may cause visible asymmetries during smiling and may reflect alterations in the tooth shape and morphology, particularly in cases requiring restorative procedures. Despite being perceived as a minor health condition, presence of uneven gingival margins usually impacts the smile aesthetics and could affect the individual's appearance, self‐esteem, and overall quality of life, especially in subjects with a high smile line. Uneven gingival margins may result from different causes, which makes an accurate diagnosis fundamental for its treatment planning. Orthodontic treatment often serves as a conservative approach for leveling these margins, by achieving the most appropriate tooth position. This article reviews the rationale, differential diagnosis, and clinical management of uneven gingival margins using orthodontic tooth movements, providing insights for orthodontists, periodontists, and restorative dentists on the interdisciplinary care needed to correct this condition, and hence, to improve the subject's smile aesthetics.
EzySCR: A free and easy tool for scoring event‐related skin conductance responses in the first, second, and third interval latency windows
Authors: Ney Luke J. , Pardo Jorge L. , Lipp Ottmar V. 
Published: October 2024

AbstractSkin conductance is a commonly used physiological measure during psychology experiments, such as during fear conditioning. Methods for scoring skin conductance responses (SCRs) are highly heterogeneous, though most researchers agree that manually inspected scores provide the highest quality data when compared to most available fully automated scoring methods. However, manual scoring is extremely time‐consuming. We developed a semi‐automated scoring program that reduces the time required to process SCR data at a level of quality akin to manual scoring. In contrast to all previous scoring programs, our program enables scoring of first interval response (FIR), second interval response (SIR), and third interval response (TIR) SCRs. Using interclass correlation coefficients (ICCs), Bland–Altman plots and Pareto analysis, we show here that our method is highly reliable and produces data that are almost identical to data that are manually scored and scored using LEDALAB. This software is very easy to use and is freely available to download and modify. We expect that this software will be helpful in reducing the time required to produce high quality FIR, SIR, and TIR skin conductance data for psychology researchers around the world.
Geochemical exploration and baseline from marine sediments in the fjords, channels and straits of Magellan, Chilean Patagonia
Authors: Ayala‐Lara Nicolás , Moncada Daniel , De Pascale Gregory , Deckart Katja , Townley Brian , Quiroga Eduardo 
Published: October 2024

AbstractChilean Patagonia has a complex geological history dominated recently by Quaternary glaciers and rivers that have carried sediments from the mountains to depositional environments within marine fjords and channels. Although much is known about onshore placer deposits, little is known about these deposits and depositional systems in the offshore realm. This study analyzes the chemistry and mineralogy of marine sediments collected in the Strait of Magellan and around the region. This study aims to comprehend the distribution, concentration and provenance of critical/strategic elements and precious metals. In collaboration with the Cabo de Hornos research vessel of the Chilean Navy, 63 sediment samples were collected using a box core sampler, complemented with coastal beach samples. These samples underwent petrographic and geochemical analysis. The predominant opaque minerals identified in these samples are mainly iron oxides (magnetite–hematite‐ilmenite) and sulfides (pyrite, exceptional greigite). A comparison of the average element concentration for all samples for different baseline values revealed the following findings. As, Bi, Li, Re, Sb, Se, Te, and Pd exhibit positive anomalies for the Upper Continental Crust (UCC); Re, Se, and Sr. exhibit positive anomalies for Marine Sediments (MS), and Bi, Cs, Li, Re, Se, Sn, and Te show positive anomalies relative to the Folded Belt (FB). The main contrast anomalies occur in the following locations. Almirantazgo Sound (Sn, Ba, Sb, and Tm); Concepción Channel (Re, Sr., and Te); Smyth Channel (Mn, Re, Sb, Sr., Te, and Se); Almirante Montt Gulf (Mn, Re, and Sb); Nelson Strait (Re, Sr., and Te); Ancho Pass (Ti and Sr); Europa Fjord (Bi and Sn); Del Hambre Pass (Sr); Magdalena Channel and Sound (Sr); Froward Pass (Se), and Whiteside Channel (Mn). Regarding precious metals, silver exhibits contrasting anomalies relative to the UCC in seafloor sediments in the Almirante Montt Gulf (0.161 ppm) and Concepción Channel (0.101 ppm). Palladium contrast anomaly is observed in the Peel Estuary (8 ppb) and Platinum contrast anomalies occur in the Concepción (3 and 5 ppb) and Smyth Channels (4 ppb). Finally, gold, in comparison to the South Patagonian Batholith, reveals contrasting anomalies that occur in the Concepción Channel (8 ppb), Peel Estuary (6.7 and 8 ppb), Nelson Strait (7 ppb), Almirante Montt Gulf (6 ppb), Forward Pass (8 ppb), and Ancho Pass (7 ppb). In summary, the presented results provide valuable insights into the geological and geochemical baseline of the region, offering a better understanding of the relationship with depositional basins and source zones onshore during the late‐Quaternary.
Ricœur Before the ‘Hermeneutical Turn’: Two Works on the Early RicœurRicœur at the Limits of Philosophy: God, Creation, and Evil, BarnabasAspray, Cambridge University Press, 2022 (ISBN 978-1-009-18674-2), x + 254 pp., hb £75A Companion to Ricœur's The Symbolism of Evil, Scott Davidson (ed.), Lexington Books, 2020 (ISBN 978-1-4985-8714-3), xx + 226 pp., hb £73
Authors: Best Jonathan 
Published: October 2024

AbstractThis review article explores two recent works on Paul Ricœur, A Companion to Ricoeur's The Symbolism of Evil, edited by Scott Davidson, and Ricœur at the Limits of Philosophy: God, Creation, and Evil by Barnabas Aspray. Both works focus on Ricœur's early works, before the ‘hermeneutical turn’. In this review, I show how both works demonstrate Ricœur's applicability to contemporary theological thought, especially concerning the symbols of creation and evil. Ultimately, both works show the depth and complexity of Ricœur's early work and his continued importance for understanding how the symbols of creation, existence, finitude and God are deep and multifaceted.
Paul on SalvationPaul and the Economy of Salvation: Reading from the Perspective of the Last Judgment, Brendan Byrne, SJ, Baker Academic, 2021 (ISBN 978‐1‐5409‐6289‐8), xvi + 286 pp., 7hb $45The Letter to the Romans: A Short Commentary, Frederick DaleBruner, Eerdmans, 2021 (ISBN 978‐0‐8028‐7943‐1), xiv + 218 pp., hb $26.99The New Perspective on Grace: Paul and the Gospel after Paul and the Gift, EdwardAdams, Dorothea H.Bertschmann, Stephen J.Chester, Jonathan A.Linebaugh, and Todd D.Still (eds), Eerdmans, 2021 (ISBN‐978‐0‐8028‐7891‐5), xiv + 402 pp., hb $64.99Glorification and the Life of Faith, AshleyCocksworth and David F.Ford, Baker Academic, 2023 (ISBN 978‐1‐5409‐6158‐6), xviii + 170 pp., pb $24.99
Authors: O'Leary Joseph S. 
Published: October 2024

AbstractThe majestic sequence of saving events in Rom 8:29–30 provides a framework within which to consider the four books reviewed here: ‘For those whom he foreknew he also predestined to be conformed to the image of his Son, in order that he might be the first‐born among many brethren. And those whom he predestined he also called; and those whom he called he also justified; and those whom he justified he also glorified’.
Effect of application of dental varnishes on the properties and chemical composition in irradiated teeth
Authors: Guzmán Sonia , López Pia , Cortés Olga 
Published: October 2024

AbstractAimsTo analyze the protective properties of fluor dental varnishes in teeth subjected to radiotherapy.Methods and resultsEighty teeth were irradiated with a single dose of 60 Gy. Samples were randomized, and the following groups were made: negative control (n = 16); irradiation control (n = 16); irradiation + Duraphat (n = 16); irradiation + Mi Varnish (n = 16); and irradiation + Rivastar (n = 16). Energy dispersive x‐ray (EDX) analysis and Raman spectrometry were performed to analyze the elemental composition and enamel's chemical structure. The Mi Varnish group presented a lower value (p < .05) in the Ca/F ratio than the other groups. Duraphat group presents differences (p < .05) in the ratio 1070 cm1‐960 cm−1 compared to all the other groups.ConclusionBased on these in vitro results, the different varnishes used showed a similar preventive effect on the lesions produced by radiotherapy, with none standing out over the others
Nature and significance of Late Pleistocene to Holocene thick evaporite deposits of the Danakil Depression, Afar, Ethiopia
Authors: Rime Valentin , Negga Haileyesus , Fentimen Robin , Rüggeberg Andres , El Korh Afifé , Pirkenseer Claudius , Schaegis Jean‐Charles , Hajdas Irka , Adatte Thierry , Atnafu Balemwal , Kidane Tesfaye , Foubert Anneleen 
Published: October 2024

AbstractLarge evaporite deposits, reaching several hundreds of metres of thickness, occur in many basins of our planet but remain poorly understood due to the absence of modern analogues. The origin of ancient evaporites and their highly variable sedimentation rates are often debated and ambiguous. The Danakil rift basin in northern Afar (Ethiopia) features several hundreds of metres of evaporites with deposition still continuing today and, as such, represents a unique modern analogue for older thick evaporite deposits. This study focuses on the multi‐proxy analysis of a 625 m long core from the central part of the basin. The core record, dominated by halite (ca 60%) with subordinate clastic sediments (ca 35%) and potash minerals (ca 5%) reveals, for the first time, the Late Pleistocene to Recent geological and environmental history of the basin. Sediments experienced restricted marine conditions after the last Late Pleistocene marine incursion in the basin, followed by a hypersaline stage leading to the near‐desiccation of the basin with the deposition of thick halite and potash deposits. Subsequent recycling of marginal halite deposits by meteoric waters in lacustrine and salt pan environments significantly increased the evaporite thickness in the subsiding central part of the basin. These findings have implications for the understanding of older thick evaporite deposits that formed in similar depositional settings. They show that several hundred of metres of evaporite can form in less than 128 kyr by evaporation of meteoric and seawater following a single marine flooding of the basin.
Paternal HLA‐Derived Epitopes and Live Birth in Secondary Recurrent Pregnancy Loss: New Insights From a Clinical Trial
Authors: Krog Maria Christine , Peereboom Emma T. M. , Geneugelijk Kirsten , Matern Benedict M. , Kolte Astrid Marie , Christiansen Ole Bjarne , Steffensen Rudi , Nielsen Henriette Svarre , Spierings Eric 
Published: October 2024

ABSTRACTRecurrent pregnancy loss (RPL), defined as two or more pregnancy losses before the 24th week of gestation, affects 1%–3% of women worldwide. Approximately, 40% of RPL cases are secondary RPL (sRPL), where women have given birth before facing pregnancy losses. The underlying causes of RPL remain unclear, but immune‐related factors may play a role. Previously, a randomised controlled trial using immunoglobulin (IVIG) in sRPL women with a history of four pregnancy losses performed in our RPL unit did not show significant effects of IVIG treatment overall. Yet, some evidence suggests potential benefits for a subset of sRPL patients. In the cohort used for the randomised controlled trial, we examined the role of maternal HLA class II‐presented fetal HLA‐derived epitopes in sRPL using the predicted indirectly recognisable HLA epitopes (PIRCHE‐II) algorithm. In the placebo group, sRPL mothers with an anti‐HLA antibody response had higher PIRCHE‐II scores when having a live birth compared with sRPL women who experienced another pregnancy loss. This difference was not observed in the IVIG‐treated group. Furthermore, as a proxy for T‐cell memory, the number of overlapping peptides between the two paternal haplotypes in couples having live births without treatment displayed a larger number of overlapping peptides. This effect was primarily driven by class II‐derived peptides. These results suggest that specific combinations of sRPL mothers and fathers, particularly those with an anti‐HLA antibody response, may generate higher PIRCHE‐II scores, which could contribute to successful live births. Understanding these immune interactions may provide insights for personalised diagnostic and therapeutic strategies in sRPL.
Redefining ‘sustainability’: A systematic approach for defining and assessing ‘sustainability’ and ‘social sustainability’
Authors: de Fine Licht Karl , Folland Anna 
Published: October 2024

AbstractIn recent years, the pursuit of social sustainability has intensified, especially in urban development. This has resulted in numerous definitions of ‘social sustainability’ from stakeholders including researchers, non‐governmental organizations (NGOs) and both private and public sector entities. These definitions vary widely, encompassing values such as well‐being, good governance, equality, trust, diversity, and accessibility. Despite extensive contributions, a universally accepted definition remains elusive, indicating the need for further conceptual work. The primary issue is the lack of explicit criteria for adequacy, leading to a stalemate in the literature. To address this issue, de Fine Licht and Folland, in 2019, proposed a framework with nine conditions of adequacy for evaluating definitions. Building on this framework, our paper systematically analyses and critiques existing definitions and proposes new, formal definitions for both ‘sustainability’ and ‘social sustainability’. Our approach identifies central challenges in existing definitions, demonstrates their inadequacy and presents an enhanced formal definition that avoids these pitfalls. Although our definitions do not specify particular values, they offer substantial results relevant to the sustainability discourse. The novelty of our work lies in our formal definition, engagement with the conditions of adequacy and systematic critique of existing definitions.