bluuebunny/crossref_metadata_2025_split huggingface dataset:
The exceptional aspects of the confined X-class flares of solar active region 2192
Authors: Thalmann Julia K. , Su Yang , Temmer Manuela , Veronig Astrid M. 
Published: September 2016

AbstractDuring late October 2014, active region NOAA 2192 caused an unusual high level of solar activity, within an otherwise weak solar cycle. While crossing the solar disk, during a period of 11 days, it was the source of 114 flares of GOES class C1.0 and larger, including 29 M- and 6 X-flares. Surprisingly, none of the major flares (GOES class M5.0 and larger) was accompanied by a coronal mass ejection, contrary to statistical tendencies found in the past. From modeling the coronal magnetic field of NOAA 2192 and its surrounding, we suspect that the cause of the confined character of the flares is the strong surrounding and overlying large-scale magnetic field. Furthermore, we find evidence for multiple magnetic reconnection processes within a single flare, during which electrons were accelerated to unusual high energies.
Geant4 simulations of STIX Caliste-SO detector's response to solar X-ray radiation
Authors: Barylak Jaromir , Barylak Aleksandra , Mrozek Tomasz , Steślicki Marek , Podgórski Piotr , Netzel Henryka 
Published: September 2016

AbstractSpectrometer/Telescope for Imaging X-rays (STIX) is a part of Solar Orbiter (SO) science payload. SO will be launched in October 2018, and after three years of cruise phase, it will reach orbit with perihelion distance of 0.3 a.u. STIX is a Fourier imager equipped with pairs of grids that comprise the flare hard X-ray tomograph. Similar imager types were already used in the past (eq. RHESSI, Yohkoh/HXT), but STIX will incorporate Moiré modulation and a new type of pixelized detectors with CdTe sensor. We developed a method of modeling these detectors' response matrix (DRM) using the Geant4 simulations of X-ray photons interactions with CdTe crystals. Taking into account known detector effects (Fano noise, hole tailing etc.) we modeled the resulting spectra with high accuracy. Comparison of Caliste-SO laboratory measurements of 241Am decay spectrum with our results shows a very good agreement. The modeling based on the Geant4 simulations significantly improves our understanding of detector response to X-ray photons. Developed methodology gives opportunity for detailed simulation of whole instrument response with complicated geometry and secondary radiation from cosmic ray particles taken into account. Moreover, we are developing the Geant4 simulations of aging effects which decrease detector's performance.
Dark feature in EUV post-flare loops
Authors: Song Qiao , Zhang Mei , Wang Jing-Song , Feng Xue-Shang , Zhang Xiao-Xin 
Published: September 2016

AbstractPost-flare loops (PFLs) usually appear in the late phase of eruptive flares as an arcade-like loop system. The Atmospheric Imaging Assembly (AIA) on-board the Solar Dynamics Observatory (SDO) delivers continuously high temporal and spatial resolution extreme ultraviolet (EUV) observations, providing a unique chance to study the PFLs. In this work, we use SDO/AIA high-quality EUV images to study the dark loop-like features in post-flare loops (DPFLs) of an X5.4 flare. Our analysis shows that: 1) the DPFLs are darker than their surrounding and the bright loops, but are brighter than the EUV background; 2) the DPFLs appear in multiple EUV channels, which indicates that they are absorption features; 3) the DPFLs are associated with downflows that are caused by the thermal instability in the cooling process of the flare.
Updated calculations of the ionization equilibrium for the non-Maxwellian electron n-distributions in solar flares
Authors: Dzifčáková Elena , Dudík Jaroslav 
Published: September 2016

AbstractThe assumption of an equilibrium (Maxwellian) distribution of electron energies cannot explain observed high intensities of the Si XIId satellite lines relative to the Si XIII allowed lines during the flares. However, the presence of n-distribution with a higher and narrower shape than the Maxwellian one is able to explain this behavior. We calculated the ionization equilibrium for the non-thermal n-distributions using the latest atomic data for each element up to the proton number of 30. Significant changes in the shape and maxima of the ion abundance peak occur and can strongly influence the temperature diagnostics.
Flares in A-type stars?
Authors: Pedersen May G. , Antoci Victoria , Korhonen Heidi 
Published: September 2016

AbstractStellar flares are known to originate from magnetic reconnection in the atmospheres of late–type stars or through radiatively driven wind instabilities in early–type stars. Situated right between these two groups, the A–type stars are not expected to support either of the two mechanisms. However, recent studies report flare features in theKeplerlight curves of 32 A–type stars, contradicting theory. We investigate the stars reported in literature, setting strong constraints on the detection criteria. Although significantly fewer, we conclude that flare-like features are present. To determine the origin we obtained high-resolution spectra from the Nordic Optical Telescope (NOT) for the ten brightest, flaring A-type stars for 3-4 epochs. Here we present the preliminary results of these spectroscopic observations, with respect to spectral classification and binarity.
Distinguishing between coronal cloud prominences and channel prominences and their associations with solar and stellar flares
Authors: Martin Sara F. , Engvold Oddbjorn , Lin Yong , da Silva Jacqueline Alves 
Published: September 2016

AbstractTo better understand the differences between coronal cloud prominences and channel prominences, we systematically identified and analyzed coronal cloud prominences recorded in SDO/AIA images at 304 Å from 2010 May 20 through 2012 April 28. For the 225 cases identified, their numbers vary directly with the sunspot number. Their durations are typically less than 3 days. Their most frequent maximum height is 90,000 + and - 10,000 km. We offer our hypothesis that many coronal cloud prominences originate from some of the mass of previously erupted filaments ejected high out of their filament channels; subsequently part of this mass falls and collects in leaky magnetic troughs among coronal magnetic fields which constrain the leaked mass to slowly drain downward along curved trajectories where it appears as coronal rain. Currently there is inadequate evidence for a convincing correspondence between either coronal cloud prominences or channel prominences with stellar prominences detected to date.
Slipping magnetic reconnection and complex evolution of a flux rope and flare ribbons
Authors: Li Ting , Zhang Jun 
Published: September 2016

AbstractAbundant observations in recent years show that the flares are more complex than the 2D standard flare model presents. This proposes a challenge to the 2D flare model and 3D flare model has been developed. We report the complex evolution of flare ribbons and a flux rope in a C8.9 flare event. The two ribbons slipped in opposite directions along the neutral line and the eastern ribbon seemed a hook-like structure. The flare loops were crossed each other, composing a “bi-fan” system. The slipping magnetic reconnection is involved in the flare and leads to slipping motion of flare ribbons and complex evolution of flare loops. Overlying the flare loops, a large-scale flux rope was erupted and meanwhile the eastern end of the flux rope changed with time and slipped along the hook-like ribbon. The fine structures of the flux rope delineated a “triangle-flag” surface, which may imply one-half of the coronal quasi-separatrix layers that surrounds a flux rope. We suggest that the heating process of slipping magnetic reconnection during the flare caused the apparent motion of the flux rope ends.
The shape of M dwarf flares in Kepler light curves
Authors: Davenport James R. A. 
Published: September 2016

AbstractUltra-precise light curves from Kepler provide the best opportunity to determine rates and statistical properties of stellar flares. From 11 months of data on the active M4 dwarf, GJ 1243, we have built the largest catalog of flares for a single star: over 6100 events. Combining 885 of our most pristine flares, we generated an empirical white-light flare template. This high-fidelity template shows a rapid initial rise, and two distinct exponential cooling phases. This template is useful in constraining flare energies and for improved flare detection in many surveys. Complex, multi-peaked events are more common for higher energy flares in this sample. Using our flare template we characterize the structure of complex events. In this contributed talk, I presented results from our boutique study of GJ 1243, and described an expanded investigation of the structure of complex flares and their connection to solar events.
Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors
Authors: Venton G , Pérez-Alea M , Baier C , Fournet G , Quash G , Labiad Y , Martin G , Sanderson F , Poullin P , Suchon P , Farnault L , Nguyen C , Brunet C , Ceylan I , Costello R T 
Published: September 2016

AbstractThe vast majority of patients with acute myeloid leukemia (AML) achieve complete remission (CR) after standard induction chemotherapy. However, the majority subsequently relapse and die of the disease. A leukemia stem cell (LSC) paradigm has been invoked to explain this failure of CR to reliably translate into cure. Indeed, LSCs are highly enriched in CD34+CD38− leukemic cells that exhibit positive aldehyde dehydrogenase activity (ALDH+) on flow cytometry, these LSCs are resistant to currently existing treatments in AML such as cytarabine and anthracycline that, at the cost of great toxicity on normal cells, are highly active against the leukemic bulk, but spare the LSCs responsible for relapse. To try to combat the LSC population selectively, a well-characterized ALDH inhibitor by the trivial name of dimethyl ampal thiolester (DIMATE) was assessed on sorted CD34+CD38− subpopulations from AML patients and healthy patients. ALDH activity and cell viability were monitored by flow cytometry. From enzyme kinetic studies DIMATE is an active enzyme-dependent, competitive, irreversible inhibitor of ALDH1. On cells in culture, DIMATE is a powerful inhibitor of ALDHs 1 and 3, has a major cytotoxic activity on human AML cell lines. Moreover, DIMATE is highly active against leukemic populations enriched in LSCs, but, unlike conventional chemotherapy, DIMATE is not toxic for healthy hematopoietic stem cells which retained, after treatment, their self-renewing and multi-lineage differentiation capacity in immunodeficient mice, xenografted with human leukemic cells. DIMATE eradicates specifically human AML cells and spares healthy mouse hematologic cells.
Efficient sensory cortical coding optimizes pursuit eye movements
Authors: Liu Bing , Macellaio Matthew V. , Osborne Leslie C. 
Published: September 2016

AbstractIn the natural world, the statistics of sensory stimuli fluctuate across a wide range. In theory, the brain could maximize information recovery if sensory neurons adaptively rescale their sensitivity to the current range of inputs. Such adaptive coding has been observed in a variety of systems, but the premise that adaptation optimizes behaviour has not been tested. Here we show that adaptation in cortical sensory neurons maximizes information about visual motion in pursuit eye movements guided by that cortical activity. We find that gain adaptation drives a rapid (<100 ms) recovery of information after shifts in motion variance, because the neurons and behaviour rescale their sensitivity to motion fluctuations. Both neurons and pursuit rapidly adopt a response gain that maximizes motion information and minimizes tracking errors. Thus, efficient sensory coding is not simply an ideal standard but a description of real sensory computation that manifests in improved behavioural performance.
A subset of RAB proteins modulates PP2A phosphatase activity
Authors: Sacco Francesca , Mattioni Anna , Boldt Karsten , Panni Simona , Santonico Elena , Castagnoli Luisa , Ueffing Marius , Cesareni Gianni 
Published: September 2016

AbstractProtein phosphatase 2A (PP2A) is one of the most abundant serine–threonine phosphatases in mammalian cells. PP2A is a hetero-trimeric holoenzyme participating in a variety of physiological processes whose deregulation is often associated to cancer. The specificity and activity of this phosphatase is tightly modulated by a family of regulatory B subunits that dock the catalytic subunit to the substrates. Here we characterize a novel and unconventional molecular mechanism controlling the activity of the tumor suppressor PP2A. By applying a mass spectrometry-based interactomics approach, we identified novel PP2A interacting proteins. Unexpectedly we found that a significant number of RAB proteins associate with the PP2A scaffold subunit (PPP2R1A), but not with the catalytic subunit (PPP2CA). Such interactions occur in vitro and in vivo in specific subcellular compartments. Notably we demonstrated that one of these RAB proteins, RAB9, competes with the catalytic subunit PPP2CA in binding to PPP2R1A. This competitive association has an important role in controlling the PP2A catalytic activity, which is compromised in several solid tumors and leukemias.
Paradoxical cold conditions during the medieval climate anomaly in the Western Arctic
Authors: Jomelli Vincent , Lane Timothy , Favier Vincent , Masson-Delmotte Valerie , Swingedouw Didier , Rinterknecht Vincent , Schimmelpfennig Irene , Brunstein Daniel , Verfaillie Deborah , Adamson Kathryn , Leanni Laëtitia , Mokadem Fatima ,   ASTER Team, Aumaître Georges , Bourlès Didier L. , Keddadouche Karim 
Published: September 2016

AbstractIn the Northern Hemisphere, most mountain glaciers experienced their largest extent in the last millennium during the Little Ice Age (1450 to 1850 CE, LIA), a period marked by colder hemispheric temperatures than the Medieval Climate Anomaly (950 to 1250 CE, MCA), a period which coincided with glacier retreat. Here, we present a new moraine chronology based on 36Cl surface exposure dating from Lyngmarksbræen glacier, West Greenland. Consistent with other glaciers in the western Arctic, Lyngmarksbræen glacier experienced several advances during the last millennium, the first one at the end of the MCA, in ~1200 CE, was of similar amplitude to two other advances during the LIA. In the absence of any significant changes in accumulation records from South Greenland ice cores, we attribute this expansion to multi-decadal summer cooling likely driven by volcanic and/or solar forcing, and associated regional sea-ice feedbacks. Such regional multi-decadal cold conditions at the end of the MCA are neither resolved in temperature reconstructions from other parts of the Northern Hemisphere, nor captured in last millennium climate simulations.
Endocrine dysfunction following traumatic brain injury: a 5-year follow-up nationwide-based study
Authors: Yang Wei-Hsun , Chen Pau-Chung , Wang Ting-Chung , Kuo Ting-Yu , Cheng Chun-Yu , Yang Yao-Hsu 
Published: September 2016

AbstractPost-traumatic endocrine dysfunction is a complication of traumatic brain injury (TBI). However, there is lack of long-term follow-up and large sample size studies. This study included patients suffering from TBI registered in the Health Insurance Database. Endocrine disorders were identified using the ICD codes: 244 (acquired hypothyroidism), 253 (pituitary dysfunction), 255 (disorders of the adrenal glands), 258 (polyglandular dysfunction), and 259 (other endocrine disorders) with at least three outpatient visits within 1 year or one admission diagnosis. Overall, 156,945 insured subjects were included in the final analysis. The 1- and 5-year incidence rates of post-traumatic endocrinopathies were 0.4% and 2%, respectively. The risks of developing a common endocrinopathy (p < 0.001) or pituitary dysfunction (P < 0.001) were significantly higher in patients with a TBI history. Patients with a skull bone fracture had a higher risk of developing pituitary dysfunction at the 1-year follow up (p value < 0.001). At the 5-year follow up, the association between intracranial hemorrhage and pituitary dysfunction (p value: 0.002) was significant. The risk of developing endocrine dysfunction after TBI increased during the entire 5-year follow-up period. Skull bone fracture and intracranial hemorrhage may be associated with short and long-term post-traumatic pituitary dysfunction, respectively.
Bacteriophages in clinical samples can interfere with microbiological diagnostic tools
Authors: Brown-Jaque Maryury , Muniesa Maite , Navarro Ferran 
Published: September 2016

AbstractBacteriophages are viruses that infect bacteria, and they are found everywhere their bacterial hosts are present, including the human body. To explore the presence of phages in clinical samples, we assessed 65 clinical samples (blood, ascitic fluid, urine, cerebrospinal fluid, and serum). Infectious tailed phages were detected in >45% of ascitic fluid and urine samples. Three examples of phage interference with bacterial isolation were observed. Phages prevented the confluent bacterial growth required for an antibiogram assay when the inoculum was taken from an agar plate containing lysis plaques, but not when taken from a single colony in a phage-free area. In addition, bacteria were isolated directly from ascitic fluid, but not after liquid enrichment culture of the same samples, since phage propagation lysed the bacteria. Lastly, Gram-negative bacilli observed in a urine sample did not grow on agar plates due to the high densities of infectious phages in the sample.
FtsZ does not initiate membrane constriction at the onset of division
Authors: Daley Daniel O. , Skoglund Ulf , Söderström Bill 
Published: September 2016

AbstractThe source of constriction required for division of a bacterial cell remains enigmatic. FtsZ is widely believed to be a key player, because in vitro experiments indicate that it can deform liposomes when membrane tethered. However in vivo evidence for such a role has remained elusive as it has been challenging to distinguish the contribution of FtsZ from that of peptidoglycan-ingrowth. To differentiate between these two possibilities we studied the early stages of division in Escherichia coli, when FtsZ is present at the division site but peptidoglycan synthesizing enzymes such as FtsI and FtsN are not. Our approach was to use correlative cryo-fluorescence and cryo-electron microscopy (cryo-CLEM) to monitor the localization of fluorescently labeled FtsZ, FtsI or FtsN correlated with the septal ultra-structural geometry in the same cell. We noted that the presence of FtsZ at the division septum is not sufficient to deform membranes. This observation suggests that, although FtsZ can provide a constrictive force, the force is not substantial at the onset of division. Conversely, the presence of FtsN always correlated with membrane invagination, indicating that allosteric activation of peptidoglycan ingrowth is the trigger for constriction of the cell envelope during cell division in E. coli.
Acoustic diagnosis of pulmonary hypertension: automated speech- recognition-inspired classification algorithm outperforms physicians
Authors: Kaddoura Tarek , Vadlamudi Karunakar , Kumar Shine , Bobhate Prashant , Guo Long , Jain Shreepal , Elgendi Mohamed , Coe James Y , Kim Daniel , Taylor Dylan , Tymchak Wayne , Schuurmans Dale , Zemp Roger J. , Adatia Ian 
Published: September 2016

AbstractWe hypothesized that an automated speech- recognition-inspired classification algorithm could differentiate between the heart sounds in subjects with and without pulmonary hypertension (PH) and outperform physicians. Heart sounds, electrocardiograms, and mean pulmonary artery pressures (mPAp) were recorded simultaneously. Heart sound recordings were digitized to train and test speech-recognition-inspired classification algorithms. We used mel-frequency cepstral coefficients to extract features from the heart sounds. Gaussian-mixture models classified the features as PH (mPAp ≥ 25 mmHg) or normal (mPAp < 25 mmHg). Physicians blinded to patient data listened to the same heart sound recordings and attempted a diagnosis. We studied 164 subjects: 86 with mPAp ≥ 25 mmHg (mPAp 41 ± 12 mmHg) and 78 with mPAp < 25 mmHg (mPAp 17 ± 5 mmHg) (p  < 0.005). The correct diagnostic rate of the automated speech-recognition-inspired algorithm was 74% compared to 56% by physicians (p = 0.005). The false positive rate for the algorithm was 34% versus 50% (p = 0.04) for clinicians. The false negative rate for the algorithm was 23% and 68% (p = 0.0002) for physicians. We developed an automated speech-recognition-inspired classification algorithm for the acoustic diagnosis of PH that outperforms physicians that could be used to screen for PH and encourage earlier specialist referral.
Staphylococcus aureus Endocarditis as a Complication of Toxocariasis-Associated Endomyocarditis With Fibrosis: A Case Report
Authors: Kuenzli Esther , Labhardt Niklaus , Balestra Gianmarco , Weisser Maja , Zellweger Michael J. , Blum Johannes 
Published: September 2016

AbstractComplications associated with Toxocara canis infection are rare. We present a case of a patient with Staphylococcus aureus endocarditis as a complication of an endomyocardial fibrosis caused by T canis. The epidemiological, pathological, and clinical features of this rare complication are described here.
USE OF AFLIBERCEPT FOR THE MANAGEMENT OF REFRACTORY PSEUDOPHAKIC MACULAR EDEMA IN IRVINE-GASS SYNDROME AND LITERATURE REVIEW
Authors: Lin Chun-Ju , Tsai Yi-Yu 
Published: September 2016

Background/Purpose:
To present the patient treated for pseudophakic cystoid macular edema with intravitreal aflibercept.

Methods:
Interventional case report.

Case:
An 83-year-old woman presented with decreased vision 1 month after uneventful cataract surgery. After failure to respond to posterior subtenons triamcinolone and three Ranibizumab injections, the patient responded to one intravitreal aflibercept injection. Recurrence occurred two months later, and therefore three monthly injections were then given. Again the patient responded although recurrence occurred two months after treatment. The patient refused further treatment.

Conclusion:
Intravitreal aflibercept may be effective for the treatment of pseudophakic cystoid macular edema.