bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Efficient Sunlight‐Driven Photocatalytic Activity of Cu‐Doped BiOBr/g‐C3N4 Nanocomposite via Z‐Scheme Design
Authors: Bagherzadeh Shima , Asadpour Saied , Karimi‐Nazarabad Mahdi , Naderi Marzieh 
Published: October 2024

AbstractPharmaceutical pollutants introduce highly intricate compounds into the environment due to extensive structural and functional alterations resulting in adverse health effects on organisms. Herein, a novel nanocomposite is designed comprising Cu‐doped BiOBr nanoflakes and g‐C3N4 to form a dual absorber based on the organic‐inorganic electronic interface for photocatalytic degradation of tetracycline (TC). With incorporating Cu in BiOBr and compositing with g‐C3N4, the band gap decreased from 2.74 eV to 2.36 eV for BiOBr:Cu/g‐C3N4, and also light harvesting ability increased. The investigation into the degradation rate considered factors such as pH, TC concentration, photocatalyst dosage, and irradiation time, resulting in a TC degradation efficiency of 98 % within 60 min. In the prepared nanocomposite, photo‐generated electrons of BiOBr can recombine via Cu atoms as a mediator with holes in the valence band of g‐C3N4 due to their band structure position which leads to improved electron/hole separation and enhanced photocatalytic activity. The predominant active species involved in the degradation process were found to be superoxide radicals. Additionally, the photocatalyst exhibited excellent stability, retaining 88 % of its photocatalytic activity after four cycles.
Green Synthesis of Some 2‐Amino‐4 h‐Benzo[H]Chromene Derivatives in the Presence of Bimetallic Nanocomposite Based on Magnetic Mesoporous Silica Nanoparticles at Ambient Conditions
Authors: Ahmadi Atieh , Moradi Leila 
Published: October 2024

AbstractIn this research, some of 2‐amino‐4H‐benzo[h]chromene derivatives were synthesized by multicomponent reaction of 1‐naphthol, benzaldehyde derivatives and malononitrile. The reaction was performed under green conditions using water as the solvent in the presence of heterogeneous nano catalyst containing Co(II) and Cu(II) stabilized on magnetic mesoporous silica nanoparticles/tannic acid (M–MSN/TA/Co(II),Cu(II)) at room temperature. The prepared catalyst showed excellent efficiency and its magnetic properties allow easy separation. The structure and morphology of prepared catalyst was identified using Fourier transform infrared (FT‐IR), X‐ray diffraction (XRD), field emission scanning electron microscopy (FE‐SEM), energy dispersive X‐ray spectroscopy (EDX), elemental mapping, thermogravimetric analysis (TGA) and vibrating‐sample magnetometry (VSM) analysis. All of products were obtained in high to excellent yields (78–94 %) after short reaction times (20–45 min) in optimal conditions and their structures were confirmed using FT‐IR and Proton nuclear magnetic resonance (1H NMR) spectroscopic techniques. This study shows that the M–MSN/TA/Cu(II), Co(II) presents a good catalytic activity, reusability and stability compared to other catalysts.
Structure and Bonding of Titanium Alanate
Authors: Wu Junlin , Ma Li , Liu Jiang , Chen Hongshan , Chen Xiaofeng , Zhang Sa , Wang Xiaoxia 
Published: October 2024

AbstractTitanium alanate Ti(AlH4)4 is a candidate material for high‐density hydrogen storage that thus far has been scarcely investigated. This study determines the low energy structures of Ti(AlH4)4 by adopting a global optimization algorithm combined with density functional theories, and systematically compares their stabilities, electronic structures, and bonding properties with Mg(AlH4)2 and Ca(AlH4)2. Compared to other compounds, Ti(AlH4)4 is less stable and the Ti−H bond is of covalent nature with strong polarities. The covalent Ti−H interaction can weaken the Al−H bonds. Because both the ionic and covalent interactions of the Al−H bonds are the weakest in Ti(AlH4)4, it is favorable for the desorption of hydrogen.
One‐Pot Synthesis of Fused Isoxazolo[4′,5′:3,4]pyrrolo[2,1‐b] Quinazolines as Potent EGFR Targeting Anticancer Agents
Authors: Lavunuri Subbareddy , Nadh Ratnakaram Venkata 
Published: October 2024

AbstractIn response to the need for scaffolds for medical applications, synthetic chemists have developed simple and efficient methods for optimal synthesis. To investigate the synthesis of fused isoxazoles in the presence of [3+2] cycloaddition followed by C−N bond formation reaction between 3‐((4‐iodo‐3‐phenylisoxazol‐5‐yl)methyl)quinazolin‐4(3H)‐one and various nitrile oxides was carried out by previously reported conditions. The cancer activities of the synthesized compounds were then tested in vitro against two cancer cell lines, MCF‐7 and A‐549. Three of the compounds, 3‐(3,5‐dichlorophenyl) isoxazolo[4′,5′:3,4]pyrrolo[2,1‐b]quinazolin‐9(11H)‐one, 3‐(4‐fluorophenyl)isoxazolo[4′,5′:3,4]pyrrolo[2,1‐b]quinazolin‐9(11H)‐one, and 3‐(4‐(trifluoromethyl)phenyl)isoxazolo[4′,5′:3,4] pyrrolo[2,1‐b] quinazolin‐9(11H)‐one has shown superior activity against the non‐small‐cell lung cancer cell line (A‐549) than the standards 5‐fluorouracil and erlotinib. Later, in vitro EGFR results revealed that a more potent compound was more effective than the conventional medicine, erlotinib. In silico investigations of more potent compounds and erlotinib on the EGFR protein indicated that more potent compounds had comparable binding energies and inhibition constants to erlotinib.
DABCO‐Saccharin Acetate as a Novel, Recyclable and Metal‐Free Catalyst for Eco‐Friendly Synthesis of Various Pyridazino[1,2‐a]indazole and 1H‐indazolo[1,2‐b]phthalazine Heterocycles Under Solvent‐Free Conditions
Authors: Pouramiri Behjat , Hadadianpour Elahe , Parhami Azadeh 
Published: October 2024

AbstractIn this research various pyridazino[1,2‐a]indazole and 1H‐indazolo[1,2‐b]phthalazine and 1H‐indazolo[1,2‐b]phthalazine derivatives were produced with a high yield via a multi‐component reaction of dimedone, aldehyde, hydrazine and anhydride compounds in the presence of a novel DABCO‐Saccharin acetate ([DABCOH][Sac‐CH3CO2]) ionic liquid under microwave irradiation. The applied method for producing these heterocyclic compounds demonstrated a number of desirable traits, including quick reactions, high yields of the final product, and straightforward separation of the product and catalyst from the reaction mixture.
Time‐Dependent Electrical Active and Ultrasound‐Responsive Calcium Titanate Implant Coating with Immunomodulation, Osteogenesis, and Customized Antibacterial Activity
Authors: Dai Xianglin , Li Tianze , Wei Peng , Xu Yingying , Jiang Chenxinyan , Zhang Xuyue , Zhang Xianhua , Liao Lan , Wang Xiaolei 
Published: October 2024

AbstractSurgical site infection and insufficient osseointegration are notable risks factors associated with oral implant surgery. In this study, the development of a polarized calcium titanate (CT‐P) coating for titanium surfaces is proposed as a solution to these problems. The coating generated electrical stimulation (ES) can inhibit pro‐inflammatory M1‐type macrophage polarization and promote anti‐inflammatory M2‐type macrophage polarization, resulting in favorable bone immunomodulation. The ES generated by the coating can match the physiological electrical potential that will change during bone repair, thereby promoting osseointegration in vivo. In addition, the system can also achieve on‐demand antibacterial activity, mainly depending on the CT‐P coating responding to ultrasound (US) irradiation to produce reactive oxygen species (ROS) and remove Staphylococcus aureus (S. aureus) on the surface of the implant. In conclusion, this work provides valuable insights for the development and clinical application of highly efficient electroactive coatings, as well as novel solutions for the selective treatment of bacterial infections in the surgical area.
Redox Oxygen Species‐Responsive Nanotheranostics with Dual‐Channel Fluorescent Turn‐On for Early Diagnosis and Targeted Therapy of Alzheimer's Disease
Authors: Guo Qian , Wang Tianying , Qian Christopher , Wang Xinyu 
Published: October 2024

AbstractCurrent diagnosis and treatment strategies mainly focus on the pathologies of the mid‐to‐late stage of AD (Alzheimer's disease), with clinical outcomes that are far from ideal. Herein, we developed the ROS (reactive oxygen species)‐responsive brain neuronal targeting nanotheranostic platforms that possess the dual‐channel fluorescent “turn‐on” properties and release drugs in AD neurons in response to ROS, thereby simultaneously facilitating the diagnosis and therapy of early AD. Through the modification of acetylcholine receptor targeting RVG29 peptide, the nanotheranostics penetrated BBB and accumulated into diseased neurons in an intact form, consequently maximizing the diagnostic and therapeutic performance. The anti‐oxidative drug baicalein conjugated onto the surface of nanotheranostics via ROS‐cleavable boronate ester linkage rapidly released for ROS scavenging, while the encapsulated fluorophores turned on their fluorescence for AD diagnosis upon microenvironment stimuli. This nanotheranostic strategy exhibited highly sensitivity with a ROS detection limit of up to 100 µm and accurately early detection of ROS in 3×Tg AD mice at 6 months of age in vivo. In addition, it could also rescue memory defects, scavenge oxidative stress, attenuate neuroinflammation and enhance neuroprotective effect in 3×Tg AD mice. This work opens up a promising and smart strategy for early diagnosis and therapy in neurodegenerative disease.
Rebooting the Adaptive Immune Response in Immunotherapy‐Resistant Lung Adenocarcinoma Using a Supramolecular Albumin
Authors: Li Fanni , Wang Jingmei , Liu Tianya , Yang Wenguang , Li Yong , Sun Qi , Yan Jin , He Wangxiao 
Published: October 2024

AbstractDespite the availability of immune checkpoint inhibitors (ICBs) significantly prolonging the life expectancy of some lung adenocarcinoma (LUAD) patients, their implementation and long‐term effectiveness are hampered by the growing issue of acquired resistance. Herein, the bioinformatics analysis of immunotherapy‐resistant LUAD patients and the system analysis of Anti‐PD1‐resistant mice models once again validate that the resistance‐associated Wnt/β‐catenin pathway offers a promising avenue for ICB sensitization. Consequently, a mild and convenient self‐assembly between albumin and carnosic acid (CA), a Wnt inhibitor is employed, to develop a supramolecular albumin known as ABCA, serving as a reactivator for ICB. As anticipated, ABCA effectively suppress the Wnt/β‐catenin cascade in vitro and leads to significant inhibition of cell proliferation while promoting apoptosis. Most notably, ABCA restores the anticancer efficacy of Anti‐PD1 in immunotherapy‐resistant LUAD orthotopic allografting mice models by reinvigorating the adaptive immune response mediated by T lymphocytes. Furthermore, ABCA exhibits minimal adverse effects during treatment and high‐dose toxicity tests, underscoring its excellent potential for clinical translation. Collectively, the present work possesses the potential to provide innovative perspectives on the advancement of optimized immunotherapies targeting drug resistance, while also presenting a promising avenue for translating Wnt inhibitors into immunotherapeutic drugs for their clinical application.
High Efficiency Ultra‐Narrow Emission Quantum Dot Light‐Emitting Diodes Enabled by Microcavity
Authors: Zhang Fengjuan , Li Gege , Zhou Penghao , Chen Zhuoyue , Zhou Jungui , Fang Ningxiao , Kong Lingheng , Lin Qingli , Roth Stephan V. , Shen Huaibin 
Published: October 2024

AbstractA wide‐color‐gamut display enableby a narrow emission linewidth facilitates a visually immersive experience akin to the real world. Quantum dot light‐emitting diodes (QLEDs) with excellent color purity and high efficiency hold great promise as future candidates for high‐definition displays. However, most devices typically exhibit emission linewidths exceeding 20 nm, and lack a universal strategy for further enhancing the color purity. In this study, a planar microcavity structure for realizing ultra‐narrow emissions is developed by incorporating a distributed Bragg reflector into normal electroluminescent devices. By leveraging the strong optical resonance effect derived from this microcavity structure, red QLEDs are successfully fabricated with an extraordinary full width at half maximum of 11 nm in the normal direction, beyond the BT.2020 color coordinates. The fabricated red‐microcavity QLEDs exhibit a considerable enhancement in the external quantum efficiency, which increases from 28.2% to 35.6%, together with an extended operating lifetime. The strategy adopted herein will serve as an effective reference for achieving ultra‐narrow emission and high‐efficiency QLEDs.
Molybdenum Disulfide‐Based Catalysts in Organic Synthesis: State of the Art, Open Issues, and Future Perspectives
Authors: Morant‐Giner Marc , Gentile Giuseppe , Prato Maurizio , Filippini Giacomo 
Published: October 2024

AbstractIn the field of heterogeneous organic catalysis, molybdenum disulfide (MoS2) is gaining increasing attention as a catalytically active material due to its low toxicity, earth abundance, and affordability. Interestingly, the catalytic properties of this metal‐based material can be improved by several strategies. In this Perspective, through the analysis of some explicative examples, the main approaches used to prepare highly efficient MoS2‐based catalysts in relevant organic reactions are summarized and critically discussed, namely: i) increment of the specific surface area, ii) generation of the metallic 1T phase, iii) introduction of vacancies, iv) preparation of nanostructured hybrids/composites, v) doping with transition metal ions, and vi) partial oxidation of MoS2. Finally, emerging trends in MoS2‐based materials catalysis leading to a richer organic synthesis are presented.
Understanding the Relationship of Closed Pore Structure in Biomass‐ derived Hard Carbon with Cellulose Regulating Strategy
Authors: Zhou Siyu , Tang Zhi , Jin Guanhua , Tu Junjie , Dhmees Abdelghaffar S. , Tang Yougen , Sun Dan , Zhang Rui , Wang Haiyan 
Published: October 2024

AbstractRecycling waste biomass to pyrolytic carbon has become a development direction of sodium‐ion batteries (SIBs) anodes. However, it remains a challenge to precisely control the composition and structure of biomass to modify the properties of derived carbon. Herein, a strategy of hydrolyzing cellulose in phellem with sulfuric acid is proposed, which can promote cellulose fracture, reduce the graphitization and increase the content of closed pores in hard carbon. Accordingly, after the regulation of closed pore structure, the reversible capacity increased from 207 to 330 mAh g−1 at 20 mA g−1, realizing an increase of ≈130 mAh g−1 in the plateau region and the initial Coulombic efficiency (ICE) is enhanced from 78% to 90%. When applied in full cell with O3‐Na[Ni1/3Fe1/3Mn1/3]O2, it showed an energy density of 247 Wh kg−1. This strategy has certain universality, and it provides the feasibility to use low‐value cellulose‐containing biomass to fabricate high‐performance hard carbon materials.
Integrating MXene Film With Recyclable Polyethylene Glycol‐co‐Polyphosphazene Copolymer as Solid–Solid Phase Change Material for Versatile Applications
Authors: Wang Yongkang , Lin Husitu , Huang Meijie , Zhou Shiliang , Zhou Yang , Zhang Xinfang , Liu Huan , Wu Zhanpeng , Wang Xiaodong 
Published: October 2024

AbstractPhase‐change materials (PCMs) stand a pivotal advancement in thermal energy storage and management due to their reversible phase transitions to store and release an abundance of heat energy. However, conventional solid–liquid PCMs suffer from fluidity and leakage in their molten state, limiting their applications at advanced levels. Herein, a novel Zn2+‐crosslinked polyethylene glycol‐co‐polyphosphazene copolymer (PCEPN‐Zn) as a solid–solid PCM through dynamic metal‐ligand coordination is first designed and synthesized. The as‐synthesized PCEPN‐Zn is further integrated with an MXene film to construct a double‐layered phase‐change composite through layer‐by layer adhesion. Owing to the introduction of MXene film with low emissivity, good light absorptivity, and nonflammability, the resultant phase‐change composite not only presents a high latent‐heat capacity, good thermal stability, high thermal reliability, and excellent shape stability, but also exhibits a superior self‐healing ability, good recyclability, high adhesivity, and good flame‐retardant performance. It can be easily adhered to on most objects for various application scenarios. With a combination of the excellent functions derived from PCEPN‐Zn and MXene film, the developed phase‐change composite exhibits broad prospects for versatile applications in the thermal management of CPUs and Li‐ion batteries, thermal infrared stealth of high‐temperature objects, heat therapy in the clinic, and fire‐safety for various scenarios.
N, S‐Codoped 3D Carbon Protected Nanoporous MnS With Record High Sodium Ion Storage Performance for Potential Industry Applications
Authors: Miao Jun , Ci Naixuan , Cao Boxuan , Xie Guoqiang , Liu Xingjun , Qiu Hua‐Jun 
Published: October 2024

AbstractWith a high theoretical capacity, the MnS anode, however, exhibits a rather complex sodium diffusion kinetics and poor mechanical stability that hinder its application in sodium‐ion batteries (SIBs). In this work, a simple, economical, and scalable strategy is developed to inherently coat nanoporous MnS with a 3D N, S co‐doped thin carbon layer by using commercially available MnCO3 as precursors. Specifically, the strategy involves a two‐step annealing process, which converts the MnCO3 microparticles into nanoporous Mn2O3 and MnS step by step. The 3D N, S codoped carbon layer is in situ formed during the second annealing process by first coating the nanoporous Mn2O3 with a polyaniline layer. Due to the inherent 3D carbon protection and the strong electronic interaction between N, S dopants and MnS, the N, S codoped carbon protected MnS obtained at 900 °C (NS‐C@MnS‐900) anode displays a high specific capacity of 845 mAh g−1 at 0.1 A g−1, which is higher than all reported MnS‐based SIB anodes. It also shows an outstanding cyclability and rate performance, maintaining a stable capacity of ≈493 mAh g−1 after 1300 cycles at 10 A g−1, which is also the best according to knowledge. These exceptional electrochemical performances and the scalable/simple/low‐cost synthesis make the NS‐C@MnS‐900 attractive for industry application.
A Wide Color Gamut and Noniridescent Zinc‐Anode Asymmetric Electrochromic Device for Self‐Sustaining Color‐Adaptive Bio‐Camouflage System
Authors: Qin Shihua , Cao Sheng , Liu Yuwei , Chen Junyao , Li Huiying , Yang Tao , Liu Guanlin , Zhao Jialong , Zou Bingsuo 
Published: October 2024

AbstractInspired by camouflage‐colored organisms, the development of bio‐camouflage systems using electrochromic (EC) technology has gained significant interest. However, existing EC systems struggle with achieving a wide color gamut, noniridescent colors, and self‐sustainability. Herein, a self‐sustainable color‐adaptive bio‐camouflage system integrating EC and nanogenerator (NG) technologies, enabling environmental color adaptation, and thermal regulation without an external power source is proposed. The system is based on a zinc‐anode EC device (ZECD) with an asymmetric structure, incorporating flexible tungsten oxide and vanadium oxide electrodes. During the EC process, tungsten oxide shifts between blue and transparent, allowing near‐infrared thermal modulation, while the vanadium oxide transitions from yellow to transparent. This design enables reversible near‐infrared modulation and noniridescent color conversion among black, blue, green, yellow, and transparent. For the self‐sustainability of the system, an electromagnetic and triboelectric hybrid NG that collects biomechanical energy is developed. In a typical driven cycle, the integrated system transitions colors and achieves significant near‐infrared spectral modulation, demonstrating environmental adaptability and thermal regulation. Experiments on human skin and simulated chameleon color changes further confirm the system's effectiveness. This work highlights the potential of integrating EC and NG technologies to advance color‐adaptive camouflage systems, opening new an avenue for bio‐camouflage design.
Optimization of Cell Membrane Purification for the Preparation and Characterization of Cell Membrane Liposomes
Authors: de Weerd Sander , Ruiter Emma A. , Calicchia Eleonora , Portale Giuseppe , Schuringa Jan Jacob , Roos Wouter H. , Salvati Anna 
Published: October 2024

AbstractCell membrane nanoparticles have attracted increasing interest in nanomedicine because they allow to exploit the complexity of cell membrane interactions for drug delivery. Several methods are used to obtain plasma membrane to generate cell membrane nanoparticles. Here, an optimized method combining nitrogen cavitation in isotonic buffer and sucrose gradient fractionation is presented. The method allows to obtain cell membrane fractions of high purity from both suspension and adherent cells. Comparison with other common methods for membrane extraction, where mechanical lysis using cell homogenizers is performed in isotonic or hypotonic buffers, shows that the optimized procedure yields high purity membrane in a robust and reproducible way. Procedures to mix the purified membrane with synthetic lipids to obtain cell membrane liposomes (CMLs) are presented and indications on how to optimize these steps are provided. CMLs made using crude membrane isolates or the purified membrane fractions show different uptake by cells. The CMLs made with the optimized procedure and liposomes of the same composition but without cell membrane components are thoroughly characterized and compared for their size, zeta potential, bilayer and mechanical properties to confirm membrane protein inclusion in the CMLs. Cell uptake studies confirm that the inclusion of membrane components modifies liposome interactions with cells.
Thoughts on the Rational Design of MOF‐Guest Interactions for Future Intelligent Materials
Authors: Asselin Paul , Harvey Pierre D. 
Published: October 2024

AbstractThe MOF‐guest relationship is broken down in elementary phases, descriptors, and parameters. These descriptors and parameters allow precise descriptions of processes, whether they occur at the point when the guest enters the MOF, during the stay, or at the point of exiting. Description of these three phases is possible according to the location of the guest inside the MOF, the activity between MOF and guest, whether stimuli can be used, and whether a selective action can be exercised. The vocabulary provided herein can be useful to better formulate requirements when designing host‐guest interactions in, and building new classes of, intelligent materials.