bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving EFL students’ multimodal literacy through infographics
Authors: Carcamo Benjamin , Carmona Carmen 
Published: September 2024

Abstract
Given the importance of multimodality in the twenty-first century and its relevance to second language acquisition, this study aimed to assess the impact of a multimodal literacy intervention on the reading comprehension of authentic multimodal texts. The participants were EFL students enrolled in a college undergraduate translation and interpretation programme, who were divided into two groups: one serving as the control group and the other as the intervention one. The intervention, based on established multimodal instruction frameworks, utilized five handouts and lasted seven weeks. Before and after the intervention a test assessing participants’ reading comprehension was administered. The results indicated a significant increase in reading scores for both groups; however, the intervention group exhibited a more substantial improvement. Additionally, the qualitative data analysis showed that students in the intervention group valued learning about concepts related to multimodality and thought that learning about multimodality helped them become better translators.
Research on thermal comfort and energy efficiency in office buildings with high window-to-wall ratios: a case study in Qingdao
Authors: Hao Weihao , Sohn Dong-Wook 
Published: September 2024

Abstract
High window-to-wall ratios (WWRs) are commonly used in office buildings, yet their effects on thermal comfort and energy consumption are not fully understood. This study uses TRNSYS software to analyze the thermal environment of buildings with varying WWRs (0%–100%) in Qingdao. The findings show that as WWRs increase, the average monthly maximum temperatures (Tmax) rise between 1.33°C and 5.62°C. Middle floors (F2–F3) are consistently warmer than the ground (F1) and top floors (F4). In summer, higher WWRs (&gt;60%) significantly reduce the prevalence of extremely high temperatures (&gt;37°C) by 0.64% to 11.29%. High WWRs also improve nocturnal heat dissipation, increasing the percentage of temperatures within the thermal comfort range and reducing heating loads by 0.62% to 1.08%. Implementing shading facilities during summer further enhances thermal comfort and energy efficiency in buildings with high WWRs.
The development and experience of international carbon tax policy practice: a mini review
Authors: Qiao Kui , Feng Ziyue , Sun Haitao , Li Hanwen , Su Peng 
Published: September 2024

Abstract
As an environmental tax, carbon tax aims to reduce carbon emissions and promote sustainable development through economic means. Internationally, the carbon tax has gone through stages such as independent operation, slow growth, and coordination with carbon trading. The practices of carbon tax in countries like Switzerland demonstrate that carbon tax contributes to the ‘green tax shift’ between climate improvement and reduced income tax. However, the development of carbon tax has been slow in developing countries, and there is a lack of international carbon tax dispute adjustment mechanisms. This article provides an overview of the development of carbon tax systems and proposes guiding principles for the establishment of China's carbon tax system: the imposition of carbon tax in China should adopt supplementary and progressive policies, first integrating it into environmental protection taxes, and then gradually transitioning to an independent carbon tax category. It is also crucial to set carbon tax revenue elements reasonably, such as tax rates, tax bases, and tax incentives. Meanwhile, China should actively participate in international coordination on carbon tax relations to jointly address the challenges of climate change. Through the imposition and implementation of carbon tax, China could achieve its goals of peaking carbon emissions and achieving carbon neutrality, thus promoting green and low-carbon development.
Study on life-cycle carbon emission factors of electricity in China
Authors: Zhang Qiyu , Qiao Kui , Hu Congan , Su Peng , Cheng Ouyang , Yan Na , Yan Luhui 
Published: September 2024

Abstract
As China’s largest carbon-emitting sector, the power sector has been the subject of extensive attention from relevant scholars and organizations. As China’s most widely used secondary energy source, greenhouse gas (GHG) emissions from electricity often account for a significant share of total corporate or product carbon emissions. In this study, we calculated the life-cycle carbon emission factors of China’s electric power based on the ISO 14067 and PAS 2050 standards and the current development of China’s power generation industry in recent years. This study makes a preliminary prediction of China’s electricity life-cycle carbon emission factors in 2025 and 2030. The results show that the life-cycle carbon emission factors of China’s thermal, solar, hydro, wind, and nuclear power generation are 0.9976 ${\textsf{tCO}}_2\textsf{e}/\textsf{MWh}$, 0.0142 ${\textsf{tCO}}_2\textsf{e}/\textsf{MWh}$, 0.0188 ${\textsf{tCO}}_2\textsf{e}/\textsf{MWh}$, 0.0100 ${\textsf{tCO}}_2\textsf{e}/\textsf{MWh}$, and 0.0122 ${\textsf{tCO}}_2\textsf{e}/\textsf{MWh}$, respectively, and ultimately obtain the life-cycle carbon emission factors for China’s comprehensive electricity footprint is 0.6835 ${\textsf{tCO}}_2\textsf{e}/\textsf{MWh}$. Thermal power generation has a much larger carbon emission factors than other power generation modes, tens to nearly a hundred times larger than other power generation modes and contributes more than 90% of the carbon emission factors of China’s comprehensive electricity footprint; among the remaining modes of power generation, wind power generation have relatively small carbon emission factors. The predicted carbon emission factors for China’s electric power in 2025 and 2030 are 0.6144 ${\textsf{tCO}}_2\textsf{e}/\textsf{MWh}$ and 0.5154 ${\textsf{tCO}}_2\textsf{e}/\textsf{MWh}$, respectively. This study improves the accuracy of accounting for product carbon emission factors and provides data references to peer organizations, enterprises, and the government to carry out product carbon emission factors accounting.
Laparoscopic versus open colectomy for locally advanced colon cancer in obese patients: a nationwide, multicenter, propensity score-based analysis of short- and long-term outcomes
Authors: Nakajima Kentaro , Akagi Tomonori , Kono Yohei , Shiroshita Hidefumi , Ohyama Tetsuji , Saito Shuji , Kagawa Yoshinori , Nakamura Takatoshi , Ohnuma Shinobu , Kojima Yutaka , Inomata Masafumi , Yamamoto Seiichiro , Naitoh Takeshi , Sakai Yoshiharu , Watanabe Masahiko ,   Japan Society of Laparoscopic Colorectal Surgery
Published: September 2024

Abstract

Objective
This study evaluated the short-and long-term outcomes of laparoscopic colectomy versus open surgery in obese patients (body mass index ≥25 kg/m2) with locally advanced colon cancer to ascertain the non-inferiority of laparoscopic surgery to open surgery.

Methods
In this large cohort study (UMIN-ID: UMIN000033529), we retrospectively reviewed prospectively collected data from consecutive patients who underwent laparoscopic or open surgery for pathological stage II–III colon cancer between 2009 and 2013. A comparative analysis was performed after propensity score matching between the laparoscopic and open surgery groups. The primary endpoint was the 3-year relapse-free survival (RFS).

Results
We identified 1575 eligible patients from 46 institutions. Each group comprised 526 propensity score-matched patients. Comparing the laparoscopic versus open surgery group, laparoscopic surgery was significantly associated with increased median operating time (225 vs. 192.5 min; P &lt; .0001) and decreased median estimated blood loss (20 vs. 140 ml; P &lt; .0001). Lymph node retrieval (20 vs. 19; P = 0.4392) and postoperative complications (4.6% vs. 5.7%; P = 0.4851) were similar, postoperative hospital stay was shorter (10 vs. 12 days; P &lt; .0001), and the 3-year RFS rates were similar (82.8 vs. 81.2%). The hazard ratio (HR) for relapse-free survival for laparoscopic versus open surgery was 0.927 (90% confidence interval [CI], 0.747–1.150, one-sided P for non-inferiority = .001), indicating that for obese patients with colon cancer, laparoscopic surgery was non-inferior to open surgery.

Conclusion
Laparoscopic surgery in obese patients with colon cancer offers advantages in terms of short-term outcomes and no disadvantages in terms of long-term outcomes.
Intraspecific variation in leaf morphology of three widespread woody species along climatic gradients
Authors: Tang Rong , Guo Yanpei , Tang Zhiyao 
Published: September 2024

Abstract
The variation and plasticity of leaf morphology play a pivotal role in the response to environmental changes for plant individuals. Discovering the large-scale pattern of such variation can reveal plants’ general adaptive strategies. We analysed leaf morphology of three widespread woody species in the northern hemisphere using specimen data from the iDigBio and GBIF databases, to investigate the variations in the individual mean traits, in the inter- and intra-individual variability of traits, and in the allometry between traits, along climatic gradients. We found that larger and wider leaves were associated with warmer, wetter and low-sunlight habitats, while smaller but wider leaves are linked to higher wind speed, indicating the response of leaf morphology to multiple climate stresses. The inter-individual variation in leaf area was smaller in colder and windier conditions, suggesting the trait convergence among individuals under environmental filtering, while the intra-individual variation in leaf relative width (RW) was smaller in warmer habitats, indicating the similar growth optimum of leaves within one individual in more favourable conditions. Finally, the allometric exponent between leaf length (X-axis) and width (Y-axis) became greater under lower solar radiation and higher wind speed, while the squared correlation coefficient (r2) indicating phenotypic integration showed a decoupling trend under colder conditions, indicating that climate affected the variation tendency of leaf RW during leaf enlargement. These results reveal the common patterns of leaf morphology responding to climate variation spatially and underscore the necessity to consider inter- and intra-individual variability when examining plant responses to environmental changes.
Melatonin alleviates high glucose-induced cardiomyocyte injury through suppressing mitochondrial FUNDC1-DRP1 axis
Authors: Zheng Junyi , Zhao Lili , Zhang Yingying , He Wenbin , Guo Xukun , Wang Jixiang 
Published: September 2024

Abstract

Objectives
To use H9c2 cardiomyocytes to establish a diabetic cardiomyopathic model by exposing these cells to high glucose (HG), followed by treating them with melatonin (MEL) or plasmid vectors overexpressing FUN14 Domain Containing 1 (FUNDC1).

Methods
We employed quantitative real-time PCR, mitochondrial staining, and biochemical assays to measure the activity of various antioxidant and mitochondrial complex functions under various treatment conditions.

Key findings
Our results showed that HG induced the expression of FUNDC1 and increased mitochondrial oxidative stress and fragmentation, while MEL treatment reversed most of these pathological effects. Moreover, HG exposure activated dynamin-related protein 1 expression and its translocation to mitochondria. Modulation of AMP-activated protein kinase level was found to be another pathological hallmark. In silico molecular docking, analysis revealed that MEL could directly bind the catalytic groove of FUNDC1 through Van der Waal’s force and hydrogen bonding. Finally, MEL ameliorated diabetic cardiomyopathy-induced mitochondrial injury through FUNDC1 in vivo.

Conclusions
Hyperglycemia induced mitochondrial fragmentation and altered electron transport chain complex functions, which could be ameliorated by MEL treatment, suggesting its potential as a cardiovascular therapeutic.
Impact of immunoglobulin preparations on anti-HLA antibody specificity analysis
Authors: Nakagawa Rie , Matsuura Hideaki , Kojima Hayato , Abe Yuko , Yamada Ayuna , Doi Hiroki , Miura Yasuo 
Published: September 2024

Abstract

Background
Donor-specific antibodies (DSAs) targeting human leukocyte antigens (HLAs) substantially reduce the longevity of transplanted organs. Desensitization of DSA-positive renal transplant recipients is achieved through intravenous administration of immunoglobulin (IVIg). However, the presence and detectability of anti-HLA antibodies in IVIg preparations following administration are not fully understood. We aimed to assess whether immunoglobulin preparations contain anti-HLA antibodies that can be detected as passive antibodies when administered into the body.

Methods
We evaluated 3 immunoglobulin preparations from different pharmaceutical companies, using anti-HLA class I and II antibody specificity tests and immunocomplex capture fluorescence analysis (ICFA).

Results
Direct testing for anti-HLA antibodies resulted in high background errors, particularly for Venoglobulin. Diluting Venoglobulin to physiological concentrations revealed the presence of anti-HLA class I antibodies; however, no common alleles were found between the specificity identification test and ICFA.
For Glovenin and Venilon, anti-HLA class I and II antibodies were detected; however, variability was observed across different test reagent lots. Moreover, dilution of the globulin formulation revealed a prozone phenomenon.

Conclusion
The administration of IVIg complicates the accurate detection of anti-HLA antibodies, underscoring the need for careful interpretation of test results post-IVIg administration.
The Experiences of Early Career Music Therapists in a Music-based Peer Supervision Group: A Qualitative Analysis
Authors: Edmonds Lauren 
Published: September 2024

Abstract
In this study, five early career music therapists participated in a music-based peer supervision group. The participants engaged in improvisational, receptive, and recreative methods over the course of six sessions based on their presenting needs that day. Following each session, the participants completed a reflective journal that focused on aspects of their personal and professional identity. The researcher analyzed the journal entries at the conclusion of the sessions and identified three overarching themes. The themes revealed that the group provided a unique sense of community, helped them confront challenging emotions experienced both personally and professionally, and fostered a reemergence of musical self. The findings were consistent with existing literature about the unique needs early career music therapists face. Recommendations for further investigation and how this data applies to clinical practice are reviewed.
Superior probabilistic computing using operationally stable probabilistic-bit constructed by manganite nanowire
Authors: Wang Yadi , Chen Bin , Gao Wenping , Ye Biying , Niu Chang , Wang Wenbin , Zhu Yinyan , Yu Weichao , Guo Hangwen , Shen Jian 
Published: September 2024

Abstract
Probabilistic computing has emerged as a viable approach to treat optimization problems. To achieve superior computing performance, the key aspect during computation is massive sampling and tuning on the probability states of each probabilistic bit (p-bit), demanding its high stability under extensive operations. Here, we demonstrate a p-bit constructed by manganite nanowire that shows exceptionally high stability. The p-bit contains an electronic domain that fluctuates between metallic (low resistance) and insulating (high resistance) states near its transition temperature. The probability for the two states can be directly controlled by nano-ampere electrical current. Under extensive operations, the standard error of its probability values is less than 1.3%. Simulations show that our operationally stable p-bit plays the key role to achieve correct inference in Bayesian network by strongly suppressing the relative error, displaying the potential for superior computing performance. Our p-bit also serves as high quality random number generator without extra data-processing, beneficial for cryptographic applications.
Iatrogenic acute type A aortic dissection during catheter ablation for idiopathic ventricular premature contraction
Authors: Ishida Shinichi , Takemoto Yoshio , Kimata Ryutaro , Yagami Kei 
Published: September 2024

Abstract
Acute aortic dissection type A during cardiac catheterization has been reported as a rare but fatal complication. We present a case of acute aortic dissection type A occurring during catheter manipulation in the ascending aorta during mapping of ventricular premature contraction via the retrograde approach. In the present case, transthoracic echocardiography showed no pericardial effusion and no flap of the aorta, but intracardiac echo clearly showed the flap. Enhanced computed tomography revealed the aortic dissection, which extended from the ascending aorta to the bilateral common iliac artery, and the false lumen was thrombosed completely. Emergent surgery was performed and the postoperative course was uneventful, and he was discharged with no complications. Aortic dissection is a rare complication of cardiac catheterization, and early detection could prevent a fatal outcome. It is important to detect the signs and symptoms as quickly as possible and perform various diagnostic examinations.
Phenotypic presentation of MEN1 c.758delC (p.Ser253Cysfs*28) pathogenic variant: a case report
Authors: Mancini Antonio , Concolino Paola , Vergani Edoardo , Oliva Alessandro , Macis Giuseppe , Traini Emanuela , Rossi Esther Diana 
Published: September 2024

Abstract
MEN1 is a rare syndrome caused by mutations in the MEN1 gene. We describe a clinical case of MEN1 syndrome associated with a recently discovered pathogenic mutation of MEN1 gene. A 32-year-old man with a history of osteopenia, nephrolithiasis, hypercalcemia and hypophosphatemia, impaired fasting glucose, and asthenia was admitted to our outpatient unit. Primary hyperparathyroidism, sustained by three hyperplastic parathyroid glands, was diagnosed. Prolactin- and GH-secreting adenomas were ruled out. After undergoing subtotal parathyroidectomy, the patient was diagnosed with non-functioning pituitary adenoma, three pancreatic lesions, and Cushing syndrome sustained by left adrenal adenoma. The patient underwent left adrenal surgery; somatostatin analogue lanreotide was started for the pancreatic lesions; the pituitary adenoma, being small and non-secreting, was not treated. A genetic test was performed to confirm the diagnosis of MEN1 syndrome, finding an association with a recently discovered mutation: the (NM_130799.2):c.758delC (p.Ser253Cysfs*28) in exon 4.
Right pneumothorax, pneumomediastinum, pneumoperitoneum, pneumoretroperitoneum, and subcutaneous emphysema as rare complications after ERCP: a case report
Authors: Bayat Ghassan , Haneyah Farah , Merjaneh Laura , Haddad Sultaneh , Thaljah Aboud , Zambakjian Jack , Ghabally Mike 
Published: September 2024

Abstract
Endoscopic retrograde cholangiopancreatography is a complex procedure with a significant risk of severe consequences. We herein report a 56-year-old Middle Eastern female who was diagnosed with acute ascending cholangitis. Endoscopic retrograde cholangiopancreatography was performed with gallstone absorption and stent implanting. However, the patient developed significant pneumothorax; pneumomediastinum, pneumoperitoneum, pneumoretroperitoneum, and subcutaneous emphysema of the abdomen, chest, right arm and shoulder, face and right orbital area. Radiological studies demonstrated no evidence of perforation on bowel obstruction. The patient was treated successfully with good results and post-operative follow-up was unremarkable. In conclusion, air leakage following endoscopic retrograde cholangiopancreatography without evidence of perforation is extremely rare. While pneumothorax development usually requires thoracostomy; pneumomediastinum, pneumoperitoneum, pneumoretroperitoneum, and subcutaneous emphysema are usually treated conservatively.
Clinicopathologic and molecular characterization of stages II-IV gastric cancer with Claudin 18.2 expression
Authors: Kwak Yoonjin , Kim Tae-Yong , Nam Soo Kyung , Hwang Hye Jung , Han Daeyoung , Oh Hyeon Jeong , Kong Seong-Ho , Park Do Joong , Oh Do-Youn , Lee Hyuk-Joon , Im Seock-Ah , Yang Han-Kwang , Lee Hye Seung 
Published: September 2024

Abstract

Background
Claudin 18.2 (CLDN18.2) is a promising target for targeted therapies in gastric cancer (GC). This study investigated the prevalence of CLDN18.2 expression in patients with stages II-IV GC or gastroesophageal junction (GEJ) adenocarcinoma and its correlation with clinicopathologic features and other crucial GC biomarkers.

Methods
We enrolled 1000 patients diagnosed with stages II-IV GC after surgical treatment. Immunohistochemistry for CLDN18 (43-14A clone), PD-L1 (22C3 pharmDx), HER2, and FGFR2 was performed. CLDN18.2 positivity was defined as moderate-to-strong (2+/3+) membranous staining in ≥75% of tumor cells. CLDN18.2 expression was compared with biomarker expression, Epstein-Barr virus (EBV) association and microsatellite instability status, and clinicopathologic features.

Result
CLDN18.2 was positive in 34.4% of the patients. CLDN18.2 positivity was significantly higher in the middle and upper thirds than in the lower third gastric location (P &lt; .001), but there was no correlation with age, sex, or stage (P &gt; .05). CLDN18.2 positivity was rare (2.8%) in mucinous adenocarcinoma but frequent (90.9%) in a majority of gastric carcinomas with lymphoid stroma. CLDN18.2 positivity was higher in EBV-associated (P &lt; .001) and PD-L1-positive (PD-L1 CPS ≥ 5) GC (P = .014) but lower in HER2 positive GC (P = .005). CLDN18.2 positivity was not significantly associated with overall survival and disease-free survival.

Conclusion
This study provides a comprehensive evaluation of CLDN18.2 status and its correlation with the clinicopathologic characteristics of patients with stages II-IV GC in Korea and with crucial biomarkers. It may be valuable for guiding future drug development, expanding treatment options, and ultimately improving patient outcomes in GC.
An electronic energy compensation method for flattening the energy response of SiPM-GGAG:Ce,B based gamma detector
Authors: Srivastava Saurabh , Mitra Pratip , Kumar Amit , Singh Sunil , Tyagi Mohit , Kumar Aerattukkara Vinod , Topkar Anita 
Published: September 2024

Abstract
The energy response of gross gamma dose rate monitors needs to be flat in order to prevent overestimation of dose at low gamma energies. In this paper, a discriminator threshold modulation based electronic energy compensation algorithm has been proposed for SiPM-scintillator based gamma detectors. Theoretical simulation studies were carried out in order to optimize the parameters of the periodic ramp voltage used for modulation of the discriminator threshold of a SiPM-GGAG:Ce,B based gamma dose rate monitor. A customized threshold modulation circuit and signal processing electronics were developed for this gamma detector. For experimentally optimizing the parameters, the energy response studies of the detector, with and without the discriminator threshold modulation, were carried out. With the optimized parameters for a periodic ramp threshold, the count rates for 241Am (60 keV) and 60Co (1173 and 1332 keV) were observed to be within ±30% of the count rate obtained for 137Cs (662 keV). Using the electronic energy compensation techniques presented in this paper, a flat energy response of the SiPM-scintillator gamma detector for the energy range of 60 keV to 1.5 MeV could be achieved.