bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of HCC-MELD Score in Patients With Hepatocellular Carcinoma Undergoing Liver Transplantation
Authors: Guerrini Gian Piero , Pinelli Domenico , Marini Elena , Corno Vittorio , Guizzetti Michela , Zambelli Marco , Aluffi Alessandro , Lincini Lisa , Fagiuoli Stefano , Lucianetti Alessandro , Colledan Michele 
Published: December 2017

Context: Liver transplantation (LT) is considered the ideal therapy for patients with hepatocellular carcinoma (HCC) having cirrhosis but the shortage of liver donors and the risk of dropout from the wait list due to tumor progression severely limit transplantation. A new prognostic score, the HCC-model for end-stage liver disease (HCC-MELD), was developed by combining α-fetoprotein (AFP), MELD, and tumor size, to improve risk stratification of dropout in patients with HCC. Objectives: In this study, we investigated the ability of the HCC-MELD score in predicting the posttransplant for patients fulfilling Milan criteria (MC). Design: Two hundred patients with stage II tumor were retrospectively reviewed from a total of 1290 transplants performed at our institution from October 1997 through April 2015. Cox regression analysis was performed to identify the prognostic factors impacting the posttransplant survival. Results: Overall survival at 1, 5, and 10 years was 89.3%, 71.1%, and 67.2%, whereas disease-free survival was 86.4%, 66.5%, and 52.4%, respectively. Multivariate analysis showed HCC-MELD score (hazard ratio [HR] 39.6, P < .001) and microvascular invasion (HR 2.41, P = .002) to be independent risk factors for recurrence, whereas HCC diameter (HR 1.15, P = .041), HCC-MELD (HR 15.611, P = .006), and grading (HR 2.17, P = .03) proved to be predictive factors of poor overall survival. Conclusion: Our study showed the validity of the HCC-MELD equation in the evaluation of patients undergoing LT for HCC. This score offers a reliable method to assess the risk of waiting list dropout and predict posttransplantation outcomes.
MiR-145 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells through targeting FoxO1
Authors: Hao Wei , Liu Hongzhi , Zhou Lugang , Sun Yujie , Su Hao , Ni Jianqiang , He Tian , Shi Peng , Wang Xin 
Published: December 2017

In this study, we aimed to investigate the expression of miR-145 before and after hASCs osteogenic differentiation. We also intended to explore the influence of the target relationship between miR-145 and FoxO1 on osteogenic differentiation. Dual-luciferase reporter gene assay and real-time PCR were used to confirm the target relationship between miR-145 and FoxO1. Furthermore, the modulatory effects of miR-145 and FoxO1 on hASCs osteoinductive differentiation were measured by real-time PCR , Western blot, ALP staining, ARS staining, and cell immunofluorescence assay. After osteogenic differentiation, miR-145 was gradually down-regulated, while FoxO1 was up-regulated in hASCs. MiR-145 could directly target FoxO1 3′UTR. FoxO1 was negatively regulated by miR-145. After osteoinductive differentiation, BSP, Ocn, and OPN expression was lowered with the overexpression of miR-145 or the knockdown of FoxO1. Furthermore, ALP and ARS staining assay results showed weakened ALP activity and extracellular matrix calcification. When overexpressing miR-145 and FoxO1 simultaneously, no obvious change in ALP activity and extracellular matrix calcification was seen. MiR-145 could suppress hASCs osteoinductive differentiation by suppressing FoxO1 directly. Impact statement Researching on ASCs was a promising strategy to study osteogenic differentiation. The regulatory role of miR-145 on hASCs osteogenic differentiation remained partially explored. Our study revealed a novel mechanism of the osteogenic differentiation process and suggested that miR-145 and its target gene FoxO1 may be potential targets for the therapy of human osteogenic-related disorders.
Congenital cranial ventral abdominal hernia, peritoneopericardial diaphragmatic hernia and sternal cleft in a 4-year-old multiparous pregnant queen
Authors: Bismuth Camille , Deroy Claire 
Published: December 2017

Case summary Cranial ventral midline hernias, most often congenital, can be associated with other congenital abnormalities, such as sternal, diaphragmatic or cardiac malformations. A 4-year-old multiparous queen with a substernal hernia was admitted for evaluation of a mammary mass. During CT examination, a bifid sternum, the abdominal hernia containing the intestines, spleen, omentum, three fetuses, a mammary mass and an incidental peritoneopericardial diaphragmatic hernia were identified. Surgery consisted of a standard ovariohysterectomy and repair of the peritoneopericardial hernia. Primary closure of the abdominal hernia was attempted but deemed impossible even after the ovariohysterectomy, splenectomy and a partial omentectomy. An external abdominal oblique muscle flap was used to close with no tension on the cranial part of the hernia. One month postoperatively, the queen had no respiratory abnormalities and the herniorrhaphy was fully healed. Relevance and novel information This case is the first description of a 4-year-old multiparous pregnant queen with complex congenital malformations and surgical correction of a peritoneopericardial hernia and a 6 × 8 cmsubsternal hernia with an external abdominal oblique muscle flap. Life-threatening sequelae associated with large abdominal hernias can be attributed to space-occupying effects known as loss of domain and compartment syndrome, which is why a muscle flap was used in this case. The sternal cleft was not repaired because of the size of the cleft and the age of the cat.
The Utility of Objective Strength and Functional Performance to Predict Subjective Outcomes After Anterior Cruciate Ligament Reconstruction
Authors: Menzer Heather , Slater Lindsay V. , Diduch David , Miller Mark , Norte Grant , Goetschius John , Hart Joseph M. 
Published: December 2017

Background: Many clinicians release patients to return to activity after anterior cruciate ligament reconstruction (ACLR) based on time from surgery despite deficits in muscle strength and function. It is unclear whether symmetry or unilateral performance is the best predictor of subjective outcomes after ACLR. Purpose: To determine physical performance predictors of patient-reported outcomes after reconstruction. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 88 participants (49 males, 39 females; mean ± SD height, 174.0 ± 9.6 cm; weight, 76.1 ± 18.5 kg; age, 19.4 ± 3.7 years) who underwent primary, unilateral ACLR volunteered for this study. Participants had undergone reconstruction a mean of 6.9 ± 1.8 months (range, 5.0-14.1 months) before the study. All participants underwent strength testing as well as hop testing and then completed the International Knee Documentation Committee (IKDC) and Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaires. Stepwise linear regression models were used for symmetry and unilateral performance to identify the proportion of variance explained in the IKDC score, KOOS total score, KOOS-sport subscale, and time from surgery, as well as receiver operating characteristic (ROC) curve analyses on those variables that explained the most variance in patient-reported outcomes to determine cutoff thresholds. Results: No significant correlations were found between time from surgery and objective performance. The only significant predictors of IKDC score were single-hop limb symmetry index (LSI) and age ( R2 = 0.177) and unilateral triple-hop performance and age ( R2 = 0.228). The cutoff for single-hop symmetry was 0.92 (area under the curve [AUC], 0.703; P = .012), and the cutoff for normalized triple-hop distance was 3.93 (AUC, 0.726; P = .005). When stratified by age, the cutoff for single-hop symmetry was 0.81 (AUC, 0.721; P = .051) for younger patients (age <19.1 years) and was not significant for older patients (age ≥19.1 years). The cutoff for normalized triple-hop distance was 3.85 (AUC, 0.832; P = .005) in older patients and was not significant for younger patients. The only significant predictors of KOOS-sport subscale were single-hop LSI ( R2 = 0.140) and normalized knee extensor power at 180 deg/s ( R2 = 0.096). When subjective outcomes were predicted based on KOOS-sport subscale, the cutoff for single-hop symmetry was 0.85 (AUC, 0.692; P = .018). Conclusion: Hopping performance is the most predictive functional variable of subjective outcomes after reconstruction. Single-hop symmetry was most important for younger patients and unilateral triple-hop distance was most important for older patients. Clinicians should consider hopping performance when making return-to-activity decisions after ACLR.
Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia
Authors: Guilliams Kristin P. , Fields Melanie E. , Ragan Dustin K. , Eldeniz Cihat , Binkley Michael M. , Chen Yasheng , Comiskey Liam S. , Doctor Allan , Hulbert Monica L. , Shimony Joshua S. , Vo Katie D. , McKinstry Robert C. , An Hongyu , Lee Jin-Moo , Ford Andria L. 
Published: December 2017

Key Points
Exchange transfusions lower global CBF and OEF in SCA, suggesting transfusions reduce infarct risk by relieving cerebral metabolic stress. In SCA, OEF is highest in the deep white matter, where infarct risk is high; transfusions reduce the volume of tissue with elevated OEF.
Recommendations for the surgical treatment of endometriosis—part 1: ovarian endometrioma
Authors:   Working group of ESGE, ESHRE, and WES, Saridogan Ertan , Becker Christian M. , Feki Anis , Grimbizis Grigoris F. , Hummelshoj Lone , Keckstein Joerg , Nisolle Michelle , Tanos Vasilios , Ulrich Uwe A. , Vermeulen Nathalie , De Wilde Rudy Leon 
Published: December 2017

Abstract
Study question
What does this document on the surgical treatment of endometriosis jointly prepared by the European Society for Gynaecological Endoscopy (ESGE), ESHRE, and the World Endometriosis Society (WES) provide?

Summary answer
This document provides recommendations covering technical aspects of different methods of surgery for endometriomas in women of reproductive age.

What is already known
Endometriomas (ovarian endometriotic cysts) are a commonly diagnosed form of endometriosis, owing to the relative ease and accuracy of ultrasound diagnosis. They frequently present a clinical dilemma as to whether and how to treat them when found during imaging or incidentally during surgery. Previously published guidelines have provided recommendations based on the best available evidence, but without technical details on the management of endometriosis.

Study design, size and duration
A working group of ESGE, ESHRE and WES collaborated on writing recommendations on the practical aspects of endometrioma surgery.

Participants/materials, setting and methods
This document focused on endometrioma surgery. Further documents in this series will provide recommendations for surgery of deep and peritoneal endometriosis.

Main results and the role of chance
The document presents general recommendations for surgery of endometrioma and specific recommendations for cystectomy, ablation by laser or by plasma energy, electrocoagulation and a combination of these techniques applied together or with an interval between them.

Limitations and reasons for caution
Owing to the limited evidence available, recommendations are mostly based on clinical expertise.

Wider implications of the findings
These recommendations complement previous guidelines on the management of endometriosis.

Study funding/competing interests
The meetings of the working group were funded by ESGE, ESHRE and WES. CB declares to be a member of the independent data monitoring committee for a clinical study by ObsEva and receiving research grants from Bayer, Roche Diagnostics, MDNA Life Sciences and Volition. ES received honoraria for provision of training to healthcare professionals from Ethicon, Olympus and Gedeon Richter. The other authors declare that they have no conflict of interest.
Impact of Variability in Portal Venous Phase Acquisition Timing in Tumor Density Measurement and Treatment Response Assessment: Metastatic Colorectal Cancer as a Paradigm
Authors: Dercle Laurent , Lu Lin , Lichtenstein Philip , Yang Hao , Wang Deling , Zhu Jianguo , Wu Feiyun , Piessevaux Hubert , Schwartz Lawrence H. , Zhao Binsheng 
Published: December 2017

Purpose New response patterns to anticancer drugs have led tumor size–based response criteria to shift to also include density measurements. Choi criteria, for instance, categorize antiangiogenic therapy response as a decrease in tumor density > 15% at the portal venous phase (PVP). We studied the effect that PVP timing has on measurement of the density of liver metastases (LM) from colorectal cancer (CRC). Methods Pretreatment PVP computed tomography images from 291 patients with LM-CRC from the CRYSTAL trial (Cetuximab Combined With Irinotecan in First-Line Therapy for Metastatic Colorectal Cancer; ClinicalTrials.gov identifier: NCT00154102) were included. Four radiologists independently scored the scans’ timing according to a three-point scoring system: early, optimal, late PVP. Using this, we developed, by machine learning, a proprietary computer-aided quality-control algorithm to grade PVP timing. The reference standard was a computer-refined consensus. For each patient, we contoured target liver lesions and calculated their mean density. Results Contrast-product administration data were not recorded in the digital imaging and communications in medicine headers for injection volume (94%), type (93%), and route (76%). The PVP timing was early, optimal, and late in 52, 194, and 45 patients, respectively. The mean (95% CI) accuracy of the radiologists for detection of optimal PVP timing was 81.7% (78.3 to 85.2) and was outperformed by the 88.6% (84.8 to 92.4) computer accuracy. The mean ± standard deviation of LM-CRC density was 68 ± 15 Hounsfield units (HU) overall and 59.5 ± 14.9 HU, 71.4 ± 14.1 HU, 62.4 ± 12.5 HU at early, optimal, and late PVP timing, respectively. LM-CRC density was thus decreased at nonoptimal PVP timing by 14.8%: 16.7% at early PVP ( P < .001) and 12.6% at late PVP ( P < .001). Conclusion Nonoptimal PVP timing should be identified because it significantly decreased tumor density by 14.8%. Our computer-aided quality-control system outperformed the accuracy, reproducibility, and speed of radiologists’ visual scoring. PVP-timing scoring could improve the extraction of tumor quantitative imaging biomarkers and the monitoring of anticancer therapy efficacy at the patient and clinical trial levels.
Combined Experimental and Computational Study on Catalytic Cyclocoupling of Epoxides and CO2 Using Porphyrin-Based Cu(II) Metal-Organic Frameworks with 2D Coordination Networks
Authors: Murayama Tsukasa , Asano Masayuki , Ohmura Tetsushi , Usuki Arimitsu , Yasui Takeshi , Yamamoto Yoshihiko 
Published: December 2017

Abstract
The cyclocoupling of epoxides and CO2 was investigated using porphyrin-based Cu(II) metal-organic frameworks with 2D coordination networks. A variety of mono- and disubstituted epoxides were transformed into cyclic carbonates under mild and neat conditions. Several control experiments were carried out to elucidate that the catalytically active site is the dicopper paddle wheel unit rather than the copper porphyrin complex moiety. The proposed mechanism was corroborated by density functional theory calculations of a model paddle wheel unit.
Cuentos del postconflicto peruano: entre el dolor y la esperanza en Al fin de la batalla. Después del conflicto, la violencia y el terror
Authors: Ferreira Rocío 
Published: December 2017

En los cuentos de la antología Al fin de la batalla. Después del conflicto, la violencia y el terror (2015) analizamos la manera en que cada narradora visibiliza con la escritura de su relato casos y experiencias significativos de las violaciones a los derechos humanos que ocurrieron en el Perú. En el acto mismo de escribir sobre el tema, las narradoras se solidarizan e identifican con los sobrevivientes del trauma social que significó el conflicto interno armado peruano con sus políticas de exterminio de los sectores más vulnerables de la población: los indígenas, las mujeres, los niños y los pobres. Nos referimos a las vidas precarias que quedan sin derecho a la protección; es decir, los cuerpos impensables, abyectos, invisibles y que por lo tanto se consideran sacrificables. Las narradoras se resisten con la escritura al silencio, el mismo que oculta y borra del imaginario nacional las experiencias de aquellos que vivieron el trauma de uno u otro flanco de la trinchera. Más aún, el proyecto de publicación de Al fin de la batalla: Después del conflicto, la violencia y el terror es un intento por acabar con la indiferencia y buscar la empatía hacia ese “otro” y restituirlo al imaginario nacional.
Arming shoes of the fifteenth century
Authors: Volken Marquita 
Published: December 2017

AbstractMilitary footwear for the fifteenth century includes arming shoes worn under sabatons. Written sources suggest arming shoes and footwear used for fighting were ordinary shoes adapted for the purpose. Archaeological footwear was examined for signs of such modifications. Medieval shoe technology is presented, showing the range of footwear and its uses and gait biomechanics. Based on experiences from re-enactors wearing armours, medieval shoe styles are discussed for appropriateness as arming shoes. The question of why medieval military footwear shows no purposed development is addressed.
Fighting with the Longsword: Modern-day HEMA Practices
Authors: Gassmann Jack , Gassmann Jürg , Le Coultre Dominique 
Published: December 2017

Abstract
This article is based on the talk presented on 27th November 2016 in the course of the Journées d’études sur le costume et les simulateurs d’armes dans les pratiques d’arts martiaux anciens. The talk itself involved practical demonstrations and interaction with other presentations given at the event; this article does not purport to be a transcript of the presentation, but elaborates on the key themes of the presentation: The objectives of HEMA as a modern practice, and their relationship to what we know about the historical practice of the European martial arts in the Middle Ages, including physical fitness, fencing techniques and tactical awareness, based on the Fechtbücher extant. A key element of the discussion involved a comparison between the objectives of and drivers behind historical and modern tournament rule-sets.
Sibling cigarette smoking and peer network influences on substance use potential among adolescent: a population based study
Authors: Mahboubi Samira , Salimi Yahya , Jorjoran Shushtari Zahra , Rafiey Hasan , Sajjadi Homeira 
Published: December 2017

AbstractBackgroundPeer and parental substance use are established predictors for substance use among adolescent, little is known about influence of sibling cigarette smoking and its interaction with peer network on substance use potential that can introduce an important way for substance use prevention programs.ObjectiveThe aim of present study was to explore the association of sibling cigarette smoking and peer network with substance use potential among high school students in Tehran.SubjectsData were drawn from the population-based cross-sectional study of among 650 high schools students.MethodsMultiple linear regression was used in order to determine the adjusted association between cigarette smoking among family members, peer network, their interaction and substance use potential.ResultHaving a sister who smokes (B = 3.19; p < 0.01) and peer network quality were associated with substance use potential (B = −0.1; p < 0.05). The increase in mean of substance use potential associated with decreases in peer network quality score is much more than in who have a sister with a cigarette smoking habit.ConclusionHaving a sister who smokes interacts with peer network quality; appears to be one of the important mechanisms for adolescents’ tendency to substance use. These findings can help in a better understanding of substance use potential mechanisms, screening efforts and the formulation of prevention programs.
Initial-Boundary Value Problems for the Coupled Higher-Order Nonlinear Schrödinger Equations on the Half-line
Authors: Hu Bei-bei , Xia Tie-cheng , Zhang Ning , Wang Jin-bo 
Published: December 2017

AbstractIn this article, we use the unified transform method to analyze the initial-boundary value problem for the coupled higher-order nonlinear Schrödinger equations on the half-line. Suppose that the solution $\{q_1(x,t),q_2(x,t)\}$ exists, we show that it can be expressed in terms of the unique solution of a matrix Riemann–Hilbert problem formulated in the plane of the complex spectral parameter $\lambda$.
„Keine Wende“?
Authors: Damm Veit 
Published: December 2017

Abstract
This article examines financial aid for companies and the guidelines of subsidy policy in East Germany after 1989 in the context of German structural policy in the “Helmut Kohl era” (1982-1998). It comes to the conclusion that – after a short period of fast structural change in East Germany – efforts increased to rescue existing businesses and industrial sites, as well as the jobs they provided after the end of 1992, primarily through the initiative of regional actors. Financial aid for companies – particularly for funding industrial investments in modernisation and new plants – played a key role in the rescuing and restructuring process. At the same time, structural policy gradually converged with the patterns that had been formed during the political management of structural change in the “former” Federal Republic. Only the short period of the postreunification years 1991 and 1992 was characterised by the steering of structural change and the redefinition of East German industry by the markets as well as by a renunciation of subsidies for the preservation of existing jobs. The temporary retreat of the state from structural policy was partly a result of the experience of the 1980s, when structural policy was criticized for slowing down German economic growth and impeding structural change.
The Role of the Future in Law and Finance
Authors: Pacces Alessio M 
Published: December 2017

Abstract
The success of a capitalist economy rests upon the ability of finance to sustain potentially infinite growth, based on funding today the output of tomorrow. Finance, however, needs rules. The aim of the law and finance scholarship is precisely to identify the best regulation of finance to support economic growth. Traditionally, law and finance is concerned with investor protection. This would be sufficient if the future were predictable. However, because the future is uncertain, the prices of financial assets are flawed and in the short run they may result in serious mistakes, if not widespread crises. Although these mistakes are corrected in the long run, significant harm may occur in the meantime. Financial law should therefore be concerned not only with investor protection, but also with mitigating the temporary excesses of markets in allowing or restricting access to finance. The challenge of this goal is to remedy market myopia without allowing policymakers to abuse the power of governments. However imperfect, prices remain the best instrument of discipline and growth in a market economy.