bluuebunny/crossref_metadata_2025_split huggingface dataset:
The dynamic interaction between lexical and contextual frequency: A case study of (ING)
Authors: Forrest Jon 
Published: July 2017

AbstractTo identify how contextual usage frequency and lexical frequency interact when controlling for traditional linguistic constraints, this study analyzes the effect of frequency on (ING), taking into account a word's frequent context of occurrence. The data consist of 13,167 tokens of (ING) from interviews with 132 speakers conducted in Raleigh, North Carolina. Results from mixed-effect logistic regression show a strong effect of frequency on the realization of (ING), and this effect interacts with phonological context of occurrence. Frequent occurrence in environments that favor-inamplify the effect of lexical frequency; conversely, frequent occurrence in environments that favor–ingdampen the effect of overall frequency. Frequency also interacts with year of birth, showing an entrenchment of high-frequency words, lagging behind the community change toward the–ingvariant in apparent time. Overall, these findings support the usage-based position of frequency effects as the result of a dynamic interplay between context of use and cognitive systems.
Benefits of Manometer in Non-Invasive Ventilatory Support
Authors: Lacerda Rodrigo Silva , de Lima Fernando Cesar Anastácio , Bastos Leonardo Pereira , Fardin Vinco Anderson , Schneider Felipe Britto Azevedo , Luduvico Coelho Yves , Fernandes Heitor Gomes Costa , Bacalhau João Marcus Ramos , Bermudes Igor Matheus Simonelli , da Silva Claudinei Ferreira , da Silva Luiza Paterlini , Pezato Rogério 
Published: July 2017

AbstractIntroductionEffective ventilation during cardiopulmonary resuscitation (CPR) is essential to reduce morbidity and mortality rates in cardiac arrest. Hyperventilation during CPR reduces the efficiency of compressions and coronary perfusion.ProblemHow could ventilation in CPR be optimized? The objective of this study was to evaluate non-invasive ventilator support using different devices.MethodsThe study compares the regularity and intensity of non-invasive ventilation during simulated, conventional CPR and ventilatory support using three distinct ventilation devices: a standard manual resuscitator, with and without airway pressure manometer, and an automatic transport ventilator. Student’s t-test was used to evaluate statistical differences between groups. P values <.05 were regarded as significant.ResultsPeak inspiratory pressure during ventilatory support and CPR was significantly increased in the group with manual resuscitator without manometer when compared with the manual resuscitator with manometer support (MS) group or automatic ventilator (AV) group.ConclusionThe study recommends for ventilatory support the use of a manual resuscitator equipped with MS or AVs, due to the risk of reduction in coronary perfusion pressure and iatrogenic thoracic injury during hyperventilation found using manual resuscitator without manometer.LacerdaRS, de LimaFCA, BastosLP, VincoAF, SchneiderFBA, CoelhoYL, FernandesHGC, BacalhauJMR, BermudesIMS, da SilvaCF, da SilvaLP, PezatoR. Benefits of manometer in non-invasive ventilatory support. Prehosp Disaster Med. 2017;32(6):615–620.
An optimal multi-layer reinsurance policy under conditional tail expectation
Authors: Najafabadi Amir T. Payandeh , Bazaz Ali Panahi 
Published: July 2017

AbstractAn usual reinsurance policy for insurance companies admits one or two layers of the payment deductions. Under optimality criterion of minimising the Conditional Tail Expectation (CTE) risk measure of the insurer’s total risk, this article generalises an optimal stop-loss reinsurance policy to an optimal multi-layer reinsurance policy. To achieve such optimal multi-layer reinsurance policy, this article starts from a given optimal stop-loss reinsurance policy f(⋅). In the first step, it cuts down the interval [0, ∞) into intervals [0, M1) and [M1, ∞). By shifting the origin of Cartesian coordinate system to (M1, f(M1)), and showing that under the CTE criteria
$$f\left( x \right)I_{{[0,M_{{\rm 1}} )}} \left( x \right){\plus}\left( {f\left( {M_{{\rm 1}} } \right){\plus}f\left( {x{\minus}M_{{\rm 1}} } \right)} \right)I_{{[M_{{\rm 1}} ,{\rm }\infty)}} \left( x \right)$$
is, again, an optimal policy. This extension procedure can be repeated to obtain an optimal k-layer reinsurance policy. Finally, unknown parameters of the optimal multi-layer reinsurance policy are estimated using some additional appropriate criteria. Three simulation-based studies have been conducted to demonstrate: (1) the practical applications of our findings and (2) how one may employ other appropriate criteria to estimate unknown parameters of an optimal multi-layer contract. The multi-layer reinsurance policy, similar to the original stop-loss reinsurance policy is optimal, in a same sense. Moreover, it has some other optimal criteria which the original policy does not have. Under optimality criterion of minimising a general translative and monotone risk measure ρ(⋅) of either the insurer’s total risk or both the insurer’s and the reinsurer’s total risks, this article (in its discussion) also extends a given optimal reinsurance contract f(⋅) to a multi-layer and continuous reinsurance policy.
Presentation of the Coding and Assessment System for Narratives of Trauma (CASNOT): Application in Spanish Battered Women and Preliminary Analyses
Authors: Fernández-Lansac Violeta , Crespo María 
Published: July 2017

AbstractThis study introduces a new coding system, the Coding and Assessment System for Narratives of Trauma (CASNOT), to analyse several language domains in narratives of autobiographical memories, especially in trauma narratives. The development of the coding system is described. It was applied to assess positive and traumatic/negative narratives in 50 battered women (trauma-exposed group) and 50 nontrauma-exposed women (control group). Three blind raters coded each narrative. Inter-rater reliability analyses were conducted for the CASNOT language categories (multirater Kfree coefficients) and dimensions (intraclass correlation coefficients). High levels of inter-rater agreement were found for most of the language domains. Categories that did not reach the expected reliability were mainly those related to cognitive processes, which reflects difficulties in operationalizing constructs such as lack of control or helplessness, control or planning, and rationalization or memory elaboration. Applications and limitations of the CASNOT are discussed to enhance narrative measures for autobiographical memories.
A TBX5 3′UTR variant increases the risk of congenital heart disease in the Han Chinese population
Authors: Wang Feng , Liu Dong , Zhang Ran-Ran , Yu Li-Wei , Zhao Jian-Yuan , Yang Xue-Yan , Jiang Song-Shan , Ma Duan , Qiao Bin , Zhang Feng , Jin Li , Gui Yong-Hao , Wang Hong-Yan 
Published: July 2017

AbstractTBX5 is a vital transcription factor involved in cardiac development in a dosage-dependent manner. But little is known about the potential association of TBX5 3′ untranslated region (UTR) variations with congenital cardiac malformations. This study aimed to investigate the relationship between TBX5 3′UTR variants and risk for congenital heart disease (CHD) susceptibility in two Han Chinese populations, and to reveal its molecular mechanism. The relationship between TBX5 3′UTR variants and CHD susceptibility was examined in 1 177 CHD patients and 990 healthy controls in two independent case–control studies. Variant rs6489956 C>T was found to be associated with increased CHD susceptibility in both cohorts. The combined CHD risk for the CT and TT genotype carriers was 1.83 times higher than that of CC genotype, while the risk for CT or TT genotype was 1.94 times and 2.31 times higher than that of CC carriers, respectively. Quantitative real-time PCR and western blot analysis showed that T allele carriers exhibited reduced TBX5 mRNA and protein levels in CHDs tissues. Compared with C allele, T allele showed increased binding affinity to miR-9 and miR-30a in both luciferase assays and surface plasmon resonance analysis. Functional analysis confirmed that miR-9 and miR-30a downregulated TBX5 expression at the transcriptional and translational levels, respectively. The assays in zebrafish model were in support of the interaction of miR-9/30a and TBX5 3′UTR (C and T allele). We concluded that TBX5 3′UTR variant rs6489956 increased susceptibility of CHD in the Han Chinese population because it changes the binding affinity of two target miRNAs that specifically mediate TBX5 expression.
Ionic liquid accelerates the crystallization of Zr-based metal–organic frameworks
Authors: Sang Xinxin , Zhang Jianling , Xiang Junfeng , Cui Jie , Zheng Lirong , Zhang Jing , Wu Zhonghua , Li Zhihong , Mo Guang , Xu Yuan , Song Jinliang , Liu Chengcheng , Tan Xiuniang , Luo Tian , Zhang Bingxing , Han Buxing 
Published: July 2017

AbstractThe Zr-based metal–organic frameworks are generally prepared by solvothermal procedure. To overcome the slow kinetics of nucleation and crystallization of Zr-based metal–organic frameworks is of great interest and challenging. Here, we find that an ionic liquid as solvent can significantly accelerate the formation of Zr-based metal–organic frameworks at room temperature. For example, the reaction time is shortened to 0.5 h in 1-hexyl-3-methylimidazolium chloride for Zr-based metal–organic framework formation, while that in the conventional solvent N,N-dimethylformamide needs at least 120 h. The reaction mechanism was investigated in situ by 1H nuclear magnetic resonance, spectroscopy synchrotron small angle X-ray scattering and X-ray absorption fine structure. This rapid, low-energy, and facile route produces Zr-based metal–organic framework nanoparticles with small particle size, missing-linker defects and large surface area, which can be used as heterogeneous catalysts for Meerwein–Ponndorf–Verley reaction.
Antiferromagnetic domain wall as spin wave polarizer and retarder
Authors: Lan Jin , Yu Weichao , Xiao Jiang 
Published: July 2017

AbstractAs a collective quasiparticle excitation of the magnetic order in magnetic materials, spin wave, or magnon when quantized, can propagate in both conducting and insulating materials. Like the manipulation of its optical counterpart, the ability to manipulate spin wave polarization is not only important but also fundamental for magnonics. With only one type of magnetic lattice, ferromagnets can only accommodate the right-handed circularly polarized spin wave modes, which leaves no freedom for polarization manipulation. In contrast, antiferromagnets, with two opposite magnetic sublattices, have both left and right-circular polarizations, and all linear and elliptical polarizations. Here we demonstrate theoretically and confirm by micromagnetic simulations that, in the presence of Dzyaloshinskii-Moriya interaction, an antiferromagnetic domain wall acts naturally as a spin wave polarizer or a spin wave retarder (waveplate). Our findings provide extremely simple yet flexible routes toward magnonic information processing by harnessing the polarization degree of freedom of spin wave.
Cloaking of Thermoelectric Transport
Authors: Stedman Troy , Woods Lilia M. 
Published: July 2017

AbstractThe ability to control electromagnetic fields, heat currents, electric currents, and other physical phenomena by coordinate transformation methods has resulted in novel functionalities, such as cloaking, field rotations, and concentration effects. Transformation optics, as the underlying mathematical tool, has proven to be a versatile approach to achieve such unusual outcomes relying on materials with highly anisotropic and inhomogeneous properties. Most applications and designs thus far have been limited to functionalities within a single physical domain. Here we present transformation optics applied to thermoelectric phenomena, where thermal and electric flows are coupled via the Seebeck coefficient. Using laminates, we describe a thermoelectric cloak capable of hiding objects from thermoelectric flow. Our calculations show that such a cloak does not depend on the particular boundary conditions and can also operate in different single domain regimes. These proof-of-principle results constitute a significant step forward towards finding unexplored ways to control and manipulate coupled transport.
Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations
Authors: Rao Guanhua , Pierobon Mariaelena , Kim In-Kyu , Hsu Wei-Hsun , Deng Jianghong , Moon Yong-Wha , Petricoin Emanuel F. , Zhang Yu-Wen , Wang Yisong , Giaccone Giuseppe 
Published: July 2017

AbstractAccumulating evidence supports a role of the PI3K-AKT pathway in the regulation of cell motility, invasion and metastasis. AKT activation is known to promote metastasis, however under certain circumstances, it also shows an inhibitory activity on metastatic processes, and the cause of such conflicting results is largely unclear. Here we found that AKT1 is an important regulator of metastasis and down-regulation of its activity is associated with increased metastatic potential of A549 cells. Inhibition of AKT1 enhanced migration and invasion in KRAS- or EGFR-mutant non-small cell lung cancer (NSCLC) cells. The allosteric AKT inhibitor MK-2206 promoted metastasis of KRAS-mutated A549 cells in vivo. We next identified that the phosphorylation of Myristoylated alanine-rich C-kinase substrate (MARCKS) and LAMC2 protein level were increased with AKT1 inhibition, and MARCKS or LAMC2 knockdown abrogated migration and invasion induced by AKT1 inhibition. This study unravels an anti-metastatic role of AKT1 in the NSCLC cells with KRAS or EGFR mutations, and establishes an AKT1-MARCKS-LAMC2 feedback loop in this regulation.
NOD2 gene variants confer risk for secondary sclerosing cholangitis in critically ill patients
Authors: Jüngst Christoph , Stadlbauer Vanessa , Reichert Matthias C. , Zimmer Vincent , Weber Susanne N. , Ofner-Ziegenfuß Lisa , Voigtländer Torsten , Spindelböck Walter , Fickert Peter , Kirchner Gabriele I. , Lammert Frank , Lankisch Tim O. , Krawczyk Marcin 
Published: July 2017

AbstractSclerosing cholangitis in critically ill patients (SC-CIP) is a progressive cholestatic disease of unknown aetiology characterized by chronic biliary infections. Hence we hypothesized that common NOD2 (nucleotide-binding oligomerisation domain containing 2) gene variants, known risk factors for Crohn’s disease and bacterial translocation in liver cirrhosis, increase the odds of developing SC-CIP. Screening of 4,641 endoscopic retrograde cholangiography procedures identified 17 patients with SC-CIP, who were then genotyped for the three common NOD2 mutations (Cohort 1, discovery cohort). To validate the association, we subsequently tested these NOD2 variants in 29 patients from SC-CIP cohorts of three additional medical centers (Cohort 2, replication cohort). In Cohort 1, the NOD2 variants were present in 5 of 17 SC-CIP patients (29.4%), which is twice the frequency of the general population. These results were replicated in Cohort 2 with 8 patients (27.6%) showing NOD2 mutations. In contrast, polymorphisms of hepatocanalicular transporter genes did not have major impact on SC-CIP risk. This first study on genetic susceptibility in SC-CIP patients shows an extraordinary high frequency of NOD2 variation, pointing to a critical role of inherited impaired anti-bacterial defense in the development of this devastating biliary disease.
Monolithic mode-selective few-mode multicore fiber multiplexers
Authors: Riesen Nicolas , Gross Simon , Love John D. , Sasaki Yusuke , Withford Michael J. 
Published: July 2017

AbstractWith the capacity limits of standard single-mode optical fiber fast approaching, new technologies such as space-division multiplexing are required to avoid an Internet capacity crunch. Few-mode multicore fiber (FM-MCF) could allow for a two orders of magnitude increase in capacity by using the individual spatial modes in the different cores as unique data channels. We report the realization of a monolithic mode-selective few-mode multicore fiber multiplexer capable of addressing the individual modes of such a fiber. These compact multiplexers operate across the S + C + L telecommunications bands and were inscribed into a photonic chip using ultrafast laser inscription. They allow for the simultaneous multiplexing of the LP01, LP11a and LP11b modes of all cores in a 3-mode, 4-core fiber with excellent mode extinction ratios and low insertion losses. The devices are scalable to more modes and cores and therefore could represent an enabling technology for practical ultra-high capacity dense space-division multiplexing.
Metacognitive Deficiency in a Perceptual but Not a Memory Task in Methadone Maintenance Patients
Authors: Sadeghi Saeedeh , Ekhtiari Hamed , Bahrami Bahador , Ahmadabadi Majid Nili 
Published: July 2017

AbstractDrug addiction has been associated with lack of insight into one’s own abilities. However, the scope of metacognition impairment among drug users in general and opiate dependent individuals in particular is not fully understood. Investigating the impairments of metacognitive ability in Substance Dependent Individuals (SDIs) in different cognitive tasks could contribute to the ongoing debate over whether metacognition has domain-general or domain-specific neural substrates. We compared metacognitive self-monitoring ability of a group of SDIs during methadone maintenance treatment (n = 23) with a control group (n = 24) in a memory and a visual perceptual task. Post decision self judgements of probability of correct choice were obtained through trial by trial confidence ratings and were used to compute metacognitive ability. Results showed that despite comparable first order performance in the perceptual task, SDIs had lower perceptual metacognition than the control group. However, although SDIs had poorer memory performance, their metacognitive judgements in the memory task were as accurate as the control group. While it is commonly believed that addiction causes pervasive impairment in cognitive functions, including metacognitive ability, we observed that the impairment was only significant in one specific task, the perceptual task, but not in the memory task.
Locus of Adhesion and Autoaggregation (LAA), a pathogenicity island present in emerging Shiga Toxin–producing Escherichia coli strains
Authors: Montero David A. , Velasco Juliana , Del Canto Felipe , Puente Jose L. , Padola Nora L. , Rasko David A. , Farfán Mauricio , Salazar Juan C. , Vidal Roberto 
Published: July 2017

AbstractShiga Toxin-producing Escherichia coli (STEC) are a group of foodborne pathogens associated with diarrhea, dysentery, hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). Shiga toxins are the major virulence factor of these pathogens, however adhesion and colonization to the human intestine is required for STEC pathogenesis. A subset of STEC strains carry the Locus of Enterocyte Effacement (LEE) pathogenicity island (PAI), which encodes genes that mediate the colonization of the human intestine. While LEE-positive STEC strains have traditionally been associated with human disease, the burden of disease caused by STEC strains that lacks LEE (LEE-negative) has increased recently in several countries; however, in the absence of LEE, the molecular pathogenic mechanisms by STEC strains are unknown. Here we report a 86-kb mosaic PAI composed of four modules that encode 80 genes, including novel and known virulence factors associated with adherence and autoaggregation. Therefore, we named this PAI as Locus of Adhesion and Autoaggregation (LAA). Phylogenomic analysis using whole-genome sequences of STEC strains available in the NCBI database indicates that LAA PAI is exclusively present in a subset of emerging LEE-negative STEC strains, including strains isolated from HC and HUS cases. We suggest that the acquisition of this PAI is a recent evolutionary event, which may contribute to the emergence of these STEC.
Intracoronary Imaging, Cholesterol Efflux, and Transcriptomics after Intensive Statin Treatment in Diabetes
Authors: Chamaria Surbhi , Johnson Kipp W. , Vengrenyuk Yuliya , Baber Usman , Shameer Khader , Divaraniya Aparna A. , Glicksberg Benjamin S. , Li Li , Bhatheja Samit , Moreno Pedro , Maehara Akiko , Mehran Roxana , Dudley Joel T. , Narula Jagat , Sharma Samin K. , Kini Annapoorna S. 
Published: July 2017

AbstractResidual atherothrombotic risk remains higher in patients with versus without diabetes mellitus (DM) despite statin therapy. The underlying mechanisms are unclear. This is a retrospective post-hoc analysis of the YELLOW II trial, comparing patients with and without DM (non-DM) who received rosuvastatin 40 mg for 8–12 weeks and underwent intracoronary multimodality imaging of an obstructive nonculprit lesion, before and after therapy. In addition, blood samples were drawn to assess cholesterol efflux capacity (CEC) and changes in gene expression in peripheral blood mononuclear cells (PBMC). There was a significant reduction in low density lipoprotein-cholesterol (LDL-C), an increase in CEC and beneficial changes in plaque morphology including increase in fibrous cap thickness and decrease in the prevalence of thin cap fibro-atheroma by optical coherence tomography in DM and non-DM patients. While differential gene expression analysis did not demonstrate differences in PBMC transcriptome between the two groups on the single-gene level, weighted gene coexpression network analysis revealed two modules of coexpressed genes associated with DM, Collagen Module and Platelet Module, related to collagen catabolism and platelet function respectively. Bayesian network analysis revealed key driver genes within these modules. These transcriptomic findings might provide potential mechanisms responsible for the higher cardiovascular risk in DM patients.
Calcium Ion Induced Structural Changes Promote Dimerization of Secretagogin, Which Is Required for Its Insulin Secretory Function
Authors: Lee Jae-Jin , Yang Seo-Yun , Park Jimin , Ferrell James E. , Shin Dong-Hae , Lee Kong-Joo 
Published: July 2017

AbstractSecretagogin (SCGN), a hexa EF-hand calcium binding protein, plays key roles in insulin secretion in pancreatic β-cells. It is not yet understood how the binding of Ca2+ to human SCGN (hSCGN) promotes secretion. Here we have addressed this question, using mass spectrometry combined with a disulfide searching algorithm DBond. We found that the binding of Ca2+ to hSCGN promotes the dimerization of hSCGN via the formation of a Cys193-Cys193 disulfide bond. Hydrogen/deuterium exchange mass spectrometry (HDX-MS) and molecular dynamics studies revealed that Ca2+ binding to the EF-hands of hSCGN induces significant structural changes that affect the solvent exposure of N-terminal region, and hence the redox sensitivity of the Cys193 residue. These redox sensitivity changes were confirmed using biotinylated methyl-3-nitro-4-(piperidin-1-ylsulfonyl) benzoate (NPSB-B), a chemical probe that specifically labels reactive cysteine sulfhydryls. Furthermore, we found that wild type hSCGN overexpression promotes insulin secretion in pancreatic β cells, while C193S-hSCGN inhibits it. These findings suggest that insulin secretion in pancreatic cells is regulated by Ca2+ and ROS signaling through Ca2+-induced structural changes promoting dimerization of hSCGN.