bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing teaching responsiveness to children’s inquiry in science: A case study of professional development for pre-school teachers
Authors: Louca Loucas T. , Tzialli Dora , Skoulia Thea , Constantinou Constantinos P. 
Published: October 2017

Supporting inquiry in the science classroom is challenging work, demanding that teachers utilize abilities for addressing and responding to children’s inquiry. These abilities include, (a) knowledge of the various forms of in-class scientific inquiry; (b) abilities for evaluating elements of children’s inquiry which teachers identify; and (c) a repertoire of instructional strategies, from which to choose in order to respond to children’s in-class inquiry. Developing these abilities depends largely on teachers’ preparation and subsequent professional development (PD) in teaching science. Our purpose in this paper is to describe the design of a professional development program (PDP) for pre-school teachers in Cyprus, seeking to help them develop teacher responsiveness to children’s inquiry. We draw on data from an implementation of this PDP to illustrate how teachers have begun developing their sensitivity towards children’s in-class inquiry and building a repertoire of responses.
Dans les terres sauvages à la recherche du sublime
Authors: BINIK Oriana 
Published: October 2017

L’article traite de la question des motivations pour le tourisme sombre, du point de vue émotionnel. Il est supposé, en particulier, que le « sublime » représente l’expérience émotionnelle d’être placé au centre du processus de la fascination. L’analyse proposée ici crée un parallèle entre les notions de « sublime », de « awe » et de l’« inquiétante étrangeté ». Deux dimensions sont en outre identifiées pour orienter la recherche empirique et relever la présence de cet état émotionnel chez les dark tourists.
De la relégation à la participation : les avatars socioculturels d’un aménagement en station de montagne, les snowparks
Authors: PABION MOURIES Johanne , REYNIER Véronique , SOULÉ Bastien , BOURDEAU Philippe 
Published: October 2017

Innovation emblématique de la fin des années 1990, l’aménagement desnowparksa largement participé du renouvellement de l’offre des sports d’hiver dans les années 2000. Rapidement généralisés, ces espaces « nouvelles glisses » représentent désormais un enjeu en termes d’attractivité des stations. Depuis leur création, ils ont connu de multiples transformations sur les plans physique, mais surtout organisationnel et social. Cet article, basé sur une enquête multisite mêlant ethnographie, entretiens et approche documentaire, s’attache à l’analyse des deux dernières dimensions. En dépassant une lecture purement technicienne dessnowparks, il s’agit de mettre en perspective la dynamique socioculturelle propre et le virage participatif inédit dans l’univers des sports d’hiver, qui sont à l’œuvre non sans contradictions dans la conception et la gestion de ces espaces de pratique.
Self‐apposing stent‐assisted coil embolization for the treatment of coronary artery aneurysm
Authors: Gasparini Gabriele L. , Oreglia Jacopo A. , Reimers Bernhard 
Published: October 2017

AbstractCoronary artery aneurysms (CAA) represent an uncommon disease with yet unclear standards of treatment. Clinical and anatomic characteristics determine choice of treatment. Stent‐assisted coil embolization has been described as a valuable option for management of patients with wide‐neck coronary aneurysms. Choice of appropriate stent sizing can be challenging particularly when there is a large difference between proximal and distal diameters. We report a case of stent‐assisted coil embolization of a coronary aneurysm using a self‐expandable stent. This type of stent can be helpful to treat CAA involving coronary sites where marked tapering of vessel diameter is often present.
Feasibility of coronary angiography and percutaneous coronary intervention after transcatheter aortic valve replacement using a Medtronic™ self‐expandable bioprosthetic valve
Authors: Htun Wah Wah , Grines Cindy , Schreiber Theodore 
Published: October 2017

AbstractBackground and ObjectiveWith aging, the progression of atherosclerosis in the coronary arteries is expected. The Medtronic™ self‐expandable aortic bioprosthetic valve is deployed in the supra‐annular position, and it has been challenging to selectively engage coronary arteries post‐transcatheter aortic valve replacement (TAVR) even though there are diamond‐shaped spaces in the mesh frame within the valve. Given the scarcity of data, we analyzed angiographic and clinical data from all patients requiring coronary angiography (CA) or intervention post‐TAVR.MethodsFrom January 2012 to December 2016, 403 patients were treated for severe aortic stenosis with TAVR at our center using the Medtronic™ self‐expandable valve. This study included patients who underwent CA with or without percutaneous coronary intervention (PCI) after TAVR.ResultsTwenty‐eight patients underwent 43 CAs after TAVR at our institution. Eleven patients (39%) were women. More than 90% of the procedures were performed for acute coronary syndrome. Thirty‐six cases were performed using the transfemoral approach (83%). Forty‐two of 43 (97%) left coronary arteries were selectively engaged, and 29 of 32 (90%) right coronary arteries were selectively engaged. We were able to engage 11 saphenous vein grafts and two left internal mammary artery grafts selectively (100%). The mean fluoroscopy time for diagnostic CA was 11.5 min, and for PCI, instantaneous wave‐free ratio, or intravascular ultrasound (IVUS) interrogation, it was 19 minutes. The mean amount of contrast used for diagnostic CA was 102 cc per case, and for PCI, iFR, or IVUS, it was 146 cc per case. No periprocedural complication was noted.ConclusionsCA with or without PCI after TAVR is feasible with supra‐annular self‐expandable valves. With the proper technique in experienced hands, it can be conducted safely.
Impact of flow, gradient, and left ventricular function on outcomes after transcatheter aortic valve replacement
Authors: Carreras Edward T. , Kaneko Tsuyoshi , Ramirez‐Del Val Fernando , Pelletier Marc P. , Sobieszczyk Piotr S. , Bhatt Deepak L. , Shah Pinak B. 
Published: October 2017

AbstractObjectivesTo assess the impact of low flow with and without preserved left ventricular ejection fraction (LVEF) on outcomes after transcatheter aortic valve replacement (TAVR).BackgroundPrior studies have shown that patients with low flow, AVG, and LVEF have worse outcomes after TAVR. It is unclear whether low AVG and LVEF remain prognostic after adjusting for flow, and how the outcomes of patients with low flow with and without preserved LVEF compare after TAVR. The goal of this study was to provide insight into these open questions.MethodsData from 340 TAVR patients at Brigham and Women's Hospital from 2011 through 2015 were analyzed. Low flow was defined as stroke volume index (SVI) ≤35 mL/m2, low AVG as mean gradient < 40 mmHg, and reduced LVEF as < 50%.ResultsLow flow was present in 96 (28.2%) patients, 48 (50.0%) of whom also had reduced LVEF. At 1 year, low flow was associated with increased mortality (21.9 vs 7.4%; P = 0.0002) and heart failure (HF) (20.8 vs 5.3%; P = 0.0113). Among patients with low flow, those with preserved LVEF had increased mortality (HR 5.17, 95% CI 2.73‐9.80; P < 0.001) and HF (HR 7.69, 95% CI 3.86‐15.31; P < 0.001). After adjusting for clinical factors, patients with low flow had increased mortality (HR 6.51, 95% CI 2.98‐14.22; P < 0.001) and HF (HR 5.52, 95% CI 2.34‐12.98; P < 0.001), while neither low AVG nor low LVEF were associated with increases in mortality or HF.ConclusionsIn patients undergoing TAVR, low flow was an independent predictor of 1‐year mortality and HF, and a stronger predictor than either low AVG or LVEF. Patients with low flow and preserved EF had increased mortality and HF at 1‐year, while those with low flow and reduced EF had outcomes similar to patients with normal flow.
Likelihood of changes in forest species suitability, distribution, and diversity under future climate: The case of Southern Europe
Authors: Noce Sergio , Collalti Alessio , Santini Monia 
Published: October 2017

AbstractForest conservation strategies and plans can be unsuccessful if the new habitat conditions determined by climate change are not considered. Our work aims at investigating the likelihood of future suitability, distribution and diversity for some common European forest species under the projected changes in climate, focusing on Southern Europe. We combine an Ensemble Platform for Species Distribution Models (SDMs) to five Global Circulation Models (GCMs) driven by two Representative Concentration Pathways (RCPs), to produce maps of future climate‐driven habitat suitability for ten categories of forest species and two time horizons. For each forest category and time horizon, ten maps of future distribution (5 GCMs by 2 RCPs) are thus combined in a single suitability map supplied with information about the “likelihood” adopting the IPCC terminology based on consensus among projections. Then, the statistical significance of spatially aggregated changes in forest composition at local and regional level is analyzed. Finally, we discuss the importance, among SDMs, that environmental predictors seem to have in influencing forest distribution. Future impacts of climate change appear to be diversified across forest categories. A strong change in forest regional distribution and local diversity is projected to take place, as some forest categories will find more suitable conditions in previously unsuitable locations, while for other categories the same new conditions will become less suited. A decrease in species diversity is projected in most of the area, with Alpine region showing the potentiality to become a refuge for species migration.
Development and evaluation of microwave‐assisted and ultrasound‐assisted methods based on a quick, easy, cheap, effective, rugged, and safe sample preparation approach for the determination of bisphenol analogues in serum and sediments
Authors: Song Shanjun , Shao Mingwu , Wang Weihua , He Yajuan , Dai Xinhua , Wang Huiyu , Liu Liliang , Guo Feng 
Published: October 2017

AbstractMicrowave‐ and ultrasound‐assisted methods based on a quick, easy, cheap, effective, rugged, and safe sample preparation approach followed by high‐performance liquid chromatography with tandem mass spectrometry were developed for the simultaneous determination of eight bisphenol analogues in serum and sediment. The developed methods provided satisfactory extraction efficiency for the energy provided by microwaves and ultrasound. Compositions of commercial sorbents (primary secondary amine, MgSO4, octadecyl‐modified silica, and graphitized carbon black) were evaluated. The ultrasound‐assisted method was suited for serum using primary secondary amine, MgSO4, and octadecyl‐modified silica as sorbents and a mixture of hexane and ethyl acetate as extraction solvent. The microwave‐assisted method worked better for sediment with tetrahydrofuran and methanol as solvents and primary secondary amine, MgSO4, octadecyl‐modified silica, and graphitized carbon black as sorbents. Other experimental parameters, such as extraction temperature and time, were also optimized. The inter‐ and intraday relative standard deviations ranged from 2.7 to 5.5%. The limits of detection were between 0.1 and 1.0 ng/mL for serum and between 0.1 and 0.5 ng/g dry weight for sediment. The proposed methods were successfully applied to seven sediment and 20 human serum samples. The results showed that the developed methods were practical for the analysis and biomonitoring of bisphenols in sera and sediment.
One‐pot synthesis of magnetic zeolitic imidazolate framework/grapheme oxide composites for the extraction of neonicotinoid insecticides from environmental water samples
Authors: Cao Xiaolin , Jiang Zejun , Wang Shanshan , Hong Sihui , Li Hui , Shao Yong , She Yongxin , Wang Jing , Jin Fen , Jin Maojun 
Published: October 2017

AbstractMagnetic zeolitic imidazolate framework 67/graphene oxide composites were synthesized by one‐pot method at room temperature for the first time. Electrostatic interactions between positively charged metal ions and both negatively charged graphene oxide and Fe3O4 nanoparticles were expected to chemically stabilize magnetic composites to generate homogeneous magnetic products. The additional amount of graphene oxide and stirring time of graphene oxide, Co2+, and Fe3O4 solution were investigated. The zeolitic imidazolate framework 67 and Fe3O4 nanoparticles were uniformly attached on the surface of graphene oxide. The composites were applied to magnetic solid‐phase extraction of five neonicotinoid insecticides in environmental water samples. The main experimental parameters such as amount of added magnetic composites, extraction pH, ionic strength, and desorption solvent were optimized to increase the capacity of adsorbing neonicotinoid insecticides. The results show limits of detection at signal‐to‐noise ratio of 3 were 0.06–1.0 ng/mL under optimal conditions. All analytes exhibited good linearity with correlation coefficients of higher than 0.9915. The relative standard deviations for five neonicotinoid insecticides in environmental samples ranged from 1.8 to 16.5%, and good recoveries from 83.5 to 117.0% were obtained, indicating that magnetic zeolitic imidazolate framework 67/graphene oxide composites were feasible for analysis of trace analytes in environmental water samples.
Number of theoretical plates achievable by a toroidal capillary electrophoresis system
Authors: Kist Tarso B. Ledur 
Published: October 2017

AbstractThe ability of a method and instrument to separate very similar compounds is related to the “plate number,” a number indicating performance. The resolution between two neighboring peaks is proportional to the square root of the plate number. Currently available commercial capillary electrophoresis instruments easily reach plate numbers of a few million. In the present work, a capillary electrophoresis system with a toroidal platform is proposed and theoretically studied with the goal of extending the achievable plate number. In this new system, electrophoresis occurs in a nonstop continuous circulating mode within a closed loop capillary (toroid). Plate numbers upwards of one billion are theoretically predicted. This could resolve hundreds of unseparated mixtures of stereoisomers and other analytes that remain without a method for their analysis.
Poly(norepinephrine)‐coated open tubular column for the separation of proteins and recombination human erythropoietin by capillary electrochromatography
Authors: Xiao Xue , Zhang Yamin , Wu Jia , Jia Li 
Published: October 2017

AbstractRecombinant human erythropoietin is an important therapeutic protein with high economic interest due to the benefits provided by its clinical use for the treatment of anemias associated with chronic renal failure and chemotherapy. In this work, a poly(norepinephrine)‐coated open tubular column was successfully prepared based on the self‐polymerization of norepinephrine under mild alkaline condition, the favorable film forming and easy adhesive properties of poly(norepinephrine). The poly(norepinephrine) coating was characterized by scanning electron microscopy and measurement of the electro‐osmotic flow. The thickness of the coating was about 431 nm. The electrochromatographic performance of the poly(norepinephrine)‐coated open tubular column was evaluated by separation of proteins. Some basic and acidic proteins including two variants of bovine serum albumin and two variants of β‐lactoglobulin achieved separation in the poly(norepinephrine)‐coated open tubular column. More importantly, the column demonstrated separation ability for the glycoforms of recombinant human erythropoietin. In addition, the column demonstrated good repeatability with the run‐to‐run, day‐to‐day, and column‐to‐column relative standard deviations of migration times of proteins less than 3.40%.
Recent advances in methods for the analysis of protein o‐glycosylation at proteome level
Authors: You Xin , Qin Hongqiang , Ye Mingliang 
Published: October 2017

AbstractO‐Glycosylation, which refers to the glycosylation of the hydroxyl group of side chains of Serine/Threonine/Tyrosine residues, is one of the most common post‐translational modifications. Compared with N‐linked glycosylation, O‐glycosylation is less explored because of its complex structure and relatively low abundance. Recently, O‐glycosylation has drawn more and more attention for its various functions in many sophisticated biological processes. To obtain a deep understanding of O‐glycosylation, many efforts have been devoted to develop effective strategies to analyze the two most abundant types of O‐glycosylation, i.e. O‐N‐acetylgalactosamine and O‐N‐acetylglucosamine glycosylation. In this review, we summarize the proteomics workflows to analyze these two types of O‐glycosylation. For the large‐scale analysis of mucin‐type glycosylation, the glycan simplification strategies including the ‘‘SimpleCell’’ technology were introduced. A variety of enrichment methods including lectin affinity chromatography, hydrophilic interaction chromatography, hydrazide chemistry, and chemoenzymatic method were introduced for the proteomics analysis of O‐N‐acetylgalactosamine and O‐N‐acetylglucosamine glycosylation.
Immobilized‐enzyme reactors integrated with capillary electrophoresis for pharmaceutical research
Authors: Schejbal Jan , Glatz Zdeněk 
Published: October 2017

AbstractEnzymes play an essential role in many aspects of pharmaceutical research as drug targets, drug metabolizers, enzyme drugs and more. In this specific field, enzyme assays are required to meet a number of specific requirements, such as low cost, easy automation, and high reliability. The integration of an immobilized‐enzyme reactor to capillary electrophoresis represents a unique approach to fulfilling these criteria by combining the benefits of enzyme immobilization, that is, increased stability and repeated use, as well as the minute sample consumption, short analysis time, and efficient analysis provided by capillary electrophoresis. In this review, we summarize, analyze, and discuss published works where pharmaceutically relevant enzymes were used to prepare capillary electrophoresis‐integrated immobilized‐enzyme reactors in an online manner. The presented assays are divided into three distinct groups based on the drug–enzyme relationship. The first, more extensively studied group employs enzymes that are considered to be therapeutic targets, the second group of assays present tools to assess drug metabolism and the third group assesses enzyme drugs. Furthermore, we examine various methods of enzyme immobilization and their implications for assay properties.
Effect of cochlear implantation on middle ear function: A three‐month prospective study
Authors: Wasson Joseph D. , Campbell Luke , Chambers Scott , Hampson Amy , Briggs Robert J. S. , O'Leary Stephen J. 
Published: October 2017

Objectives/HypothesisTo determine if cochlear implantation has a delayed effect on the middle ear conductive hearing mechanism by measuring laser Doppler vibrometry (LDV) of the tympanic membrane (TM) in both implanted and contralateral control ears preoperatively and 3 months postoperatively, and then comparing the relative change in LDV outcome measures between implanted and control ears.Study DesignProspective cohort study.MethodsEleven preoperative adult unilateral cochlear implant recipients in previously unoperated ears with normal anatomy and aerated temporal bones were included in this study. The magnitude and phase angle of umbo velocity transfer function in response to air‐ conduction (AC) stimulus, and the magnitude of umbo velocity in response to bone‐ conduction (BC) stimulus were measured in the implant ear and the contralateral control ear preoperatively and 3 months postoperatively and compared.ResultsNo significant changes in the magnitude or phase angle of TM velocity in response to either AC or BC stimulus were observed in the implanted ear relative to the contralateral control ear 3 months following cochlear implantation.ConclusionsFrom the results of LDV measurements, it can be said that cochlear implantation has no significant delayed effect on the middle ear conductive mechanism.Level of Evidence4. Laryngoscope, 128:1207–1212, 2018
Effects of supramaximal balloon dilatation pressures on adult cricoid and tracheal cartilage: A cadaveric study
Authors: Durvasula Venkata S. P. B. , Shalin Sara C. , Tulunay‐Ugur Ozlem E. , Suen James Y. , Richter Gresham T. 
Published: October 2017

Objectives/HypothesisCricoid fracture is a serious concern for balloon dilatation in airway stenosis. Furthermore, there are no studies examining tracheal rupture in balloon dilatation of stenotic segments. The aim of this study was to evaluate the effect of supramaximal pressures of balloons on the cricoid and tracheal rings.Study DesignProspective cadaveric study.MethodsSeven cadaveric laryngotracheal complexes of normal adults with intact cricothyroid membranes were acquired. Noncompliant vascular angioplasty balloons (BARD‐VIDA) were used for dilatation. The subglottis and trachea were subjected to supramaximal dilatation pressures graduated to nominal burst pressure (NBP) and, if necessary, rated burst pressure (RBP). Larger‐diameter balloons, starting from 18 mm size to 24 mm, were used. Dilatations were maintained for 3 minutes.ResultsThe cricoid ring was disrupted by larger‐diameter balloons (22 mm and 24 mm) even at lower pressures (less than NBP) in six cases. Tracheal cartilages were very distensible, and external examination after supramaximal dilatation (24 mm close to RBP) revealed no obvious cartilage fractures or trachealis tears. Histopathological examination revealed sloughing of mucosa in the areas corresponding to balloon placement, but no microfractures or disruption of the perichondrium of tracheal ring cartilages.ConclusionsThese results indicate that the cricoid is vulnerable to injury from larger balloons even at lower dilatation pressures. The tracheal cartilages and the membranous wall of the trachea remained resilient to supramaximal dilatation and larger balloons.Level of EvidenceNA. Laryngoscope, 128:1304–1309, 2018