bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated collaborative care teams to enhance service delivery to youth with mental health and substance use challenges: protocol for a pragmatic randomised controlled trial
Authors: Henderson Joanna L , Cheung Amy , Cleverley Kristin , Chaim Gloria , Moretti Myla E , de Oliveira Claire , Hawke Lisa D , Willan Andrew R , O'Brien David , Heffernan Olivia , Herzog Tyson , Courey Lynn , McDonald Heather , Grant Enid , Szatmari Peter 
Published: February 2017

IntroductionAmong youth, the prevalence of mental health and addiction (MHA) disorders is roughly 20%, yet youth are challenged to access evidence-based services in a timely fashion. To address MHA system gaps, this study tests the benefits of an Integrated Collaborative Care Team (ICCT) model for youth with MHA challenges. A rapid, stepped-care approach geared to need in a youth-friendly environment is expected to result in better youth MHA outcomes. Moreover, the ICCT approach is expected to decrease service wait-times, be more youth-friendly and family-friendly, and be more cost-effective, providing substantial public health benefits.Methods and analysisIn partnership with four community agencies, four adolescent psychiatry hospital departments, youth and family members with lived experience of MHA service use, and other stakeholders, we have developed an innovative model of collaborative, community-based service provision involving rapid access to needs-based MHA services. A total of 500 youth presenting for hospital-based, outpatient psychiatric service will be randomised to ICCT services or hospital-based treatment as usual, following a pragmatic randomised controlled trial design. The primary outcome variable will be the youth's functioning, assessed at intake, 6 months and 12 months. Secondary outcomes will include clinical change, youth/family satisfaction and perception of care, empowerment, engagement and the incremental cost-effectiveness ratio (ICER). Intent-to-treat analyses will be used on repeated-measures data, along with cost-effectiveness and cost-utility analyses, to determine intervention effectiveness.Ethics and disseminationResearch Ethics Board approval has been received from the Centre for Addiction and Mental Health, as well as institutional ethical approval from participating community sites. This study will be conducted according to Good Clinical Practice guidelines. Participants will provide informed consent prior to study participation and data confidentiality will be ensured. A data safety monitoring panel will monitor the study. Results will be disseminated through community and peer-reviewed academic channels.Trial registration numberClinicaltrials.govNCT02836080.
Acquired Resistance to the Hsp90 Inhibitor, Ganetespib, inKRAS-Mutant NSCLC Is Mediated via Reactivation of the ERK–p90RSK–mTOR Signaling Network
Authors: Chatterjee Suman , Huang Eric H.-B. , Christie Ian , Kurland Brenda F. , Burns Timothy F. 
Published: February 2017

AbstractApproximately 25% of non–small cell lung cancer (NSCLC) patients have KRAS mutations, and no effective therapeutic strategy exists for these patients. The use of Hsp90 inhibitors in KRAS-mutant NSCLC appeared to be a promising approach, as these inhibitors target many KRAS downstream effectors; however, limited clinical efficacy has been observed due to resistance. Here, we examined the mechanism(s) of acquired resistance to the Hsp90 inhibitor, ganetespib, and identified novel and rationally devised Hsp90 inhibitor combinations, which may prevent and overcome resistance to Hsp90 inhibitors. We derived KRAS-mutant NSCLC ganetespib-resistant cell lines to identify the resistance mechanism(s) and identified hyperactivation of RAF/MEK/ERK/RSK and PI3K/AKT/mTOR pathways as key resistance mechanisms. Furthermore, we found that ganetespib-resistant cells are “addicted” to these pathways, as ganetespib resistance leads to synthetic lethality to a dual PI3K/mTOR, a PI3K, or an ERK inhibitor. Interestingly, the levels and activity of a key activator of the mTOR pathway and an ERK downstream target, p90 ribosomal S6 kinase (RSK), were also increased in the ganetespib-resistant cells. Genetic or pharmacologic inhibition of p90RSK in ganetespib-resistant cells restored sensitivity to ganetespib, whereas p90RSK overexpression induced ganetespib resistance in naïve cells, validating p90RSK as a mediator of resistance and a novel therapeutic target. Our studies offer a way forward for Hsp90 inhibitors through the rational design of Hsp90 inhibitor combinations that may prevent and/or overcome resistance to Hsp90 inhibitors, providing an effective therapeutic strategy for KRAS-mutant NSCLC. Mol Cancer Ther; 16(5); 793–804. ©2017 AACR.
Prognostic Utility of a Modified HEART Score in Chest Pain Patients in the Emergency Department
Authors: McCord James , Cabrera Rafael , Lindahl Bertil , Giannitsis Evangelos , Evans Kaleigh , Nowak Richard , Frisoli Tiberio , Body Richard , Christ Michael , deFilippi Christopher R. , Christenson Robert H. , Jacobsen Gordon , Alquezar Aitor , Panteghini Mauro , Melki Dina , Plebani Mario , Verschuren Franck , French John , Bendig Garnet , Weiser Silvia , Mueller Christian , Twerenbold Raphael , Katus Hugo A. , Popp Steffen , Ordóñez-Llanos Jorge , Santalo-Bel Miquel , Horner Daniel , Dolci Alberto , Jernberg Tomas , Zaninotto Martina , Manara Alessandro , Dinkel Carina , Menassanch-Volker Sylvie , Jarausch Jochen , Zaugg Christian 
Published: February 2017

Background—
The TRAPID-AMI trial study (High-Sensitivity Troponin-T Assay for Rapid Rule-Out of Acute Myocardial Infarction) evaluated high-sensitivity cardiac troponin-T (hs-cTnT) in a 1-hour acute myocardial infarction (AMI) exclusion algorithm. Our study objective was to evaluate the prognostic utility of a modified HEART score (m-HS) within this trial.

Methods and Results—

Twelve centers evaluated 1282 patients in the emergency department for possible AMI from 2011 to 2013. Measurements of hs-cTnT (99th percentile, 14 ng/L) were performed at 0, 1, 2, and 4 to 14 hours. Evaluation for major adverse cardiac events (MACEs) occurred at 30 days (death or AMI). Low-risk patients had an m-HS≤3 and had either hs-cTnT<14 ng/L over serial testing or had AMI excluded by the 1-hour protocol. By the 1-hour protocol, 777 (60%) patients had an AMI excluded. Of those 777 patients, 515 (66.3%) patients had an m-HS≤3, with 1 (0.2%) patient having a MACE, and 262 (33.7%) patients had an m-HS≥4, with 6 (2.3%) patients having MACEs (
P
=0.007). Over 4 to 14 hours, 661 patients had a hs-cTnT<14 ng/L. Of those 661 patients, 413 (62.5%) patients had an m-HS≤3, with 1 (0.2%) patient having a MACE, and 248 (37.5%) patients had an m-HS≥4, with 5 (2.0%) patients having MACEs (
P
=0.03).

Conclusions—
Serial testing of hs-cTnT over 1 hour along with application of an m-HS identified a low-risk population that might be able to be directly discharged from the emergency department.
Long-Form and Short-Form Prenominal Adjectives Are Not Reduced Relative Clauses in Bosnian/Croatian/Serbian
Authors: Talić Aida 
Published: February 2017

Cinque (2010) treats prenominal adjectives in languages like Bosnian/Croatian/Serbian (BCS) and English either as APs in the specifiers of functional projections in the extended domain of N (direct modification) or as predicates in reduced relative clauses in the specifiers of functional projections (indirect modification), while postnominal adjectives in these languages are treated only as predicates in reduced relative clauses. In this model, the direct-modification source is associated with one set of interpretations and the indirect-modification source with a different set of interpretations. This proposed dual-source analysis raises the question whether there are any languages that mark this distinction with overt morphology. In this respect, Cinque considers languages, among them BCS, where adnominal modification has two distinct morphological shapes. Crucially, BCS adjectives have different morphological forms depending on their distribution: the “long form” and the “short form.” Cinque treats the two forms as being overt manifestations of the two sources of modification. In particular, he suggests that adnominal short-form adjectives are always reduced relative clauses (indirect modification), while long-form adjectives are ambiguous between the two sources. This proposal captures some distributional and ordering restrictions these two forms of BCS adjectives display. In this squib, I provide several empirical arguments against the claim that BCS is a language that overtly distinguishes between two sources of modification. By closely inspecting the distribution and interpretations of BCS adjectives, the ordering between the two forms in the prenominal position, and extraction possibilities out of APs, I show that both long- and short-form adjectives represent challenges for Cinque’s model. I argue that treating BCS long adjectives, as well as prenominal short adjectives, as reduced relative clauses is problematic. More generally, my investigation of interpretations that adnominal adjectives in BCS receive, including several parallels between BCS and English, leads to the conclusion that, although there may be two syntactic sources of adnominal adjectives, these different sources are not identified by two distinct sets of interpretations associated with them. I also introduce facts that are problematic for the claim that the indirect-modification source involves reduced relative clauses. The squib is organized as follows. In section 1 , I introduce Cinque’s (2010) dual-modification-source model and its predictions. In section 2 , I explore how the predictions of this model fare with respect to BCS adjectives. In sections 2.1 and 2.2 , I discuss data regarding BCS long and short adjectives, respectively, that are problematic for the dual-source analysis. Section 3 is the conclusion.
Five new species of grass cicadas in the genus Graminitigrina (Hemiptera: Cicadidae: Cicadettinae: Cicadettini) from Queensland and Northern Territory, Australia: comparative morphology, songs, behaviour and distributions
Authors: EWART A. , POPPLE L.W. , HILL K.B.R 
Published: February 2017

Five new species of small grass cicadas belonging to the genus Graminitigrina Ewart and Marques are described, together with detailed analyses of their calling songs. Four species occur in Queensland, G. aurora n. sp. from eastern central Queensland near Fairbairn Dam; G. flindensis n. sp. from central Queensland between Hughenden northwards for at least 108 km; G. einasleighi n. sp. from near The Lynd, Einasleigh River, northeastern Queensland; G. selwynensis n. sp. from the Selwyn Range, northwestern Queensland, at locations about 40 km east of Mount Isa and 25 km southwest of Cloncurry, this latter here transferred from G. bowensis Ewart and Marques; G. uluruensis n. sp. from Uluru and the Olgas in southwestern Northern Territory, extending northwards through Tennant Creek and apparently further north to near Larrimah, a linear distance of approximately 1190 km. These new species bring the known Graminitigrina species to ten, all superficially similar in colour and morphology. A key to male specimens is provided for the 10 species. Additional distribution records and additional aural song recordings are presented for G. bowensis, these requiring the transfer of populations previously identified as G. bowensis from Croydon and Georgetown, northern Gulf region, to G. karumbae Ewart and Marques. Detailed comparative analyses, including NMDS analyses, of the songs of all 10 species are provided, which show that the song parameters are appropriate to distinguish the species, although some partial overlap is noted in the waveform plots between the songs of G. uluruensis n. sp. and G. flindensis n. sp. Regional variations of song parameters are noted in the calling songs of most of the species described.
Arthritis-Related Limitations Predict Insufficient Physical Activity in Adults With Prediabetes Identified in the NHANES 2011-2014
Authors: Strauss Shiela M. , McCarthy Margaret 
Published: February 2017

Purpose The purpose of the study was to determine the extent to which arthritis-related limitations are salient in predicting less than the recommended amount of time for adults with prediabetes to spend on moderate or vigorous physical activity. Methods Data from the 2011-2014 National Health and Nutrition Examination Survey (NHANES) in the United States were used to identify the predictors of insufficient physical activity in a large sample of adults with prediabetes 20 years of age and older (n = 2536). Results When extrapolated to more than 45 million adults in the United States at least 20 years of age with prediabetes, 42.7% had insufficient physical activity. Having arthritis-related functional limitations was a significant predictor of insufficient physical activity, even after accounting for the statistically significant contributions of female sex, older age, lower education level, higher body mass index, and depression. Conclusion When educating and counseling adults with prediabetes, diabetes educators should assess for arthritis-related functional limitations when examining factors that may affect prediabetes progression. Recommendations for physical activity for those with mobility and other limitations need to be individualized within a tailored exercise program to accommodate their specific limitations.
Binge drinking affects brain oscillations linked to motor inhibition and execution
Authors: López-Caneda Eduardo , Rodríguez Holguín Socorro , Correas Ángeles , Carbia Carina , González-Villar Alberto , Maestú Fernando , Cadaveira Fernando 
Published: February 2017

Introduction: Neurofunctional studies have shown that binge drinking patterns of alcohol consumption during adolescence and youth are associated with anomalies in brain functioning. Recent evidence suggests that event-related oscillations may be an appropriate index of neurofunctional damage associated with alcoholism. However, there is no study to date that has evaluated the effects of binge drinking on oscillatory brain responses related to task performance. The purpose of the present study was to examine brain oscillations linked to motor inhibition and execution in young binge drinkers (BDs) compared with age-matched controls. Methods: Electroencephalographic activity was recorded from 64 electrodes while 72 university students (36 controls and 36 BDs) performed a visual Go/NoGo task. Event-related oscillations along with the Go-P3 and NoGo-P3 event-related potential components were analysed. Results: While no significant differences between groups were observed regarding event-related potentials, event-related oscillation analysis showed that BDs displayed a lower oscillatory response than controls in delta and theta frequency ranges during Go and NoGo conditions. Conclusions: Findings are congruent with event-related oscillation studies showing reduced delta and/or theta oscillations in alcoholics during Go/NoGo tasks. Thus, BDs appear to show disruptions in neural oscillations linked to motor inhibition and execution similar to those observed in alcohol-dependent subjects. Finally, these results are the first to evidence that oscillatory brain activity may be a sensitive indicator of underlying brain anomalies in young BDs, which could complement standard event-related potential measures.
Epidemiological Patterns of Initial and Subsequent Injuries in Collegiate Football Athletes
Authors: Williams Jacob Z. , Singichetti Bhavna , Li Hongmei , Xiang Henry , Klingele Kevin E. , Yang Jingzhen 
Published: February 2017

Background: A body of epidemiological studies has examined football injuries and associated risk factors among collegiate athletes. However, few existing studies specifically analyzed injury risk in terms of initial or subsequent injuries. Purpose: To determine athlete-exposures (AEs) and rates of initial and subsequent injury among collegiate football athletes. Study Design: Descriptive epidemiological study. Methods: Injury and exposure data collected from collegiate football players from two Division I universities (2007-2011) were analyzed. Rate of initial injury was calculated as the number of initial injuries divided by the total number of AEs for initial injuries, while the rate for subsequent injury was calculated as the number of subsequent injuries divided by the total number of AEs for subsequent injury. Poisson regression was used to determine injury rate ratio (subsequent vs initial injury), with adjustment for other covariates. Results: The total AEs during the study period were 67,564, resulting in an overall injury rate of 35.2 per 10,000 AEs. Rates for initial and subsequent injuries were 31.7 and 45.3 per 10,000 AEs, respectively, with a rate ratio (RR) of 1.4 for rate of subsequent injury vs rate of initial injury (95% CI, 1.1-1.9). Rate of injury appeared to increase with each successive injury. RR during games was 1.8 (95% CI, 1.1-3.0). The rate of subsequent injuries to the head, neck, and face was 10.9 per 10,000 AEs, nearly double the rate of initial injuries to the same sites (RR = 2.0; 95% CI, 1.1-3.5). For wide receivers, the rate of subsequent injuries was 2.2 times the rate of initial injuries (95% CI, 1.3-3.8), and for defensive linemen, the rate of subsequent injuries was 2.1 times the rate of initial injuries (95% CI, 1.1-3.9). Conclusion: The method used in this study allows for a more accurate determination of injury risk among football players who have already been injured at least once. Further research is warranted to better identify which specific factors contribute to this increased risk for subsequent injury.
Reorienting Public Health Nurses’ Practice With a Professional Practice Model
Authors: Cusack Cheryl , Cohen Benita , Mignone Javier , Chartier Mariette J. , Lutfiyya Zana 
Published: February 2017

Purpose Documents articulating public health nurses’ (PHNs’) roles, including Canadian standards and competencies, depict a broad focus working at multiple levels to improve population outcomes through the promotion of health equity. Conversely, Canadian experts depict a looming crisis, based on the rising disconnect between daily activities and ideal practice. While perfectly positioned, PHNs’ skills and abilities are under-utilized and largely invisible. The intention of this study was to develop a model to support the full scope of equity-focused PHN practice. Method A participatory action research approach was used. Qualitative data were gathered using semistructured interview guides during audio-recorded meetings. The data were coded into central themes using content analysis and constant comparison. A researcher reflexive journal and field notes were kept. A significant feature was full participant involvement. Results The outcome was a professional practice model to reframe the PHN role to focus on population health and equity. The model was imperative in promoting full scope of practice, dealing with workload pressures, and describing PHNs’ value within the organization and broader health system. Conclusion Professional practice models hold promise as frameworks to depict autonomous practice activities, situated within organizations and healthcare systems, and underpinned by nursing knowledge.
A Qualitative Study of Experiences with and Perceptions regarding Long-Acting Injectable Antipsychotics: Part II—Physician Perspectives
Authors: Iyer Srividya , Banks Nicola , Roy Marc-André , Tibbo Phil , Williams Richard , Manchanda Rahul , Chue Pierre , Malla Ashok 
Published: February 2017

Objective In many countries, including Canada, a small proportion of people with psychotic disorders receive long-acting injectable (LAI) antipsychotics (APs), despite their demonstrated effectiveness and possible advantages for improving adherence rates. Attitudes regarding LAIs among physicians may influence their prescribing practices and thereby contribute to the underuse of LAIs. Here, we report on a qualitative study of perceptions and attitudes toward LAIs among psychiatrists in Canada. Method Focus groups were conducted with 24 psychiatrists in 4 Canadian provinces. The focus groups inquired about experiences with and attitudes toward LAI APs. The sessions were audiotaped and transcribed verbatim, and transcripts were coded using a hybrid process of deductive and inductive methods. A brief pre-focus group questionnaire was administered. Results The pre-focus group questionnaires indicated that psychiatrists in our study prescribed the oral formulation of APs most of the time and had limited experience with LAIs. The focus groups yielded 4 main themes: limited knowledge about and experience with LAIs; attitudes toward LAIs (beliefs about negative perceptions of patients regarding LAIs, personal bias against needles, and consensus about some advantages of LAIs); prescribing practices around LAIs (generally seen as a last-resort option for patients with a history of nonadherence); and pragmatic barriers to using LAIs (for example, cost, storage, and staffing). Conclusion Several factors may be contributing to the underuse of LAIs and the continuing stigmatized and coercive image of LAIs. Psychiatrists may benefit from better education about LAIs, and from self-examination of their attitudes to LAIs and their prescribing practices.
Predicting serum drug level using the principles of pharmacokinetics after an overdose: a case of lithium overdose
Authors: Fernando Irosh 
Published: February 2017

Objective:In cases of drug overdose, clinicians often find it challenging to predict serum drug level and decide the optimum time for recommencing the overdosed drug.Method:This paper describes how to predict serum drug level using the principles of pharmacokinetics.Results:The proposed method and recommencement of the overdosed drug is demonstrated using a clinical case of lithium overdose.Conclusion:The proposed method can assist clinicians in predicting serum drug levels and deciding the optimum time for recommencing the overdosed drug safely. Therefore, it may reduce unnecessary repeat serum drug level procedures.