bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel approach to research engagement: Developing a targeted theory of change with Black and African-American stakeholders
Authors: Hemley Helen , Ison Juliana M. , Reynolds Marissa , Pham Tiffany , Jackson Jonathan D. 
Published: October 2024

Abstract

Purpose:
Community inclusion in research may increase the quality and relevance of research, but doing so in an equitable way is complex. Novel approaches used to build engagement with historically marginalized communities in other sectors may have relevance in the clinical research sector.

Method:
To address long-standing gaps and challenges, a stakeholder group was convened to develop a theory of change (ToC), a structured method for obtaining input from stakeholders to enhance the design, conduct, and dissemination of research. The stakeholder group, comprised of Black residents within a metropolitan area, followed a structured monthly meeting schedule for 12 months to produce an outcome map, a model that formally defines aspects of research and engagement for this community.

Results:
Stakeholders reported significant improvements in trust in and engagement with research over the 12-month period, but not changes in health empowerment (individual, organizational, or community level). Through this convening process, a ToC and outcome map were developed with the focus of building bidirectional relationships between groups identifying as Black, Indigenous, and People of Color (BIPOC) and researchers in Boston, MA. Additionally, the group developed a community ownership model and guidelines for researchers to adhere to when utilizing the ToC and outcome map with BIPOC communities.

Conclusion:
Co-ownership of models to develop bidirectional relationships between researchers and community members, such as the ToC and outcome map, may advance and further the value and reach of community-based participatory research while increasing levels of trust and engagement in research.
The rise and fall of the Clann Éinrí Aimhréidh Uí Néill: dynastic feuding and geopolitics in the late medieval Irish Sea world
Authors: Egan Simon 
Published: October 2024

AbstractDuring the late fourteenth and early fifteenth centuries, the Ulster lordship of Tír Eoghain was bitterly contested between two rival branches of the Uí Néill dynasty: the Clann Éinrí Aimhréidh and the Clann Briain Catha an Dúin. Traditionally, historians have focused mainly on the local origins and ramifications of this feud and have paid only cursory attention to how events ranging from the Shannon Estuary through to the Outer Hebrides shaped the course of this struggle. For instance, throughout the later fourteenth and early fifteenth centuries a range of different regional players from across this wider ‘Irish Sea world’ became drawn into pulled into this conflict, each possessing a vested interest in the outcome of the Uí Néill successional war. By drawing upon a rich corpus of primary sources, including Irish, Scottish and English material, this article locates the Uí Néill feud within a wider dynastic and geopolitical context. Ultimately, the article argues for the necessity of exploring this feud from within a wider geographic and dynastic framework of interpretation, and paying closer attention to how events within the Irish Sea world could impact and impinge upon the politics of the wider archipelago.
Select document: The last will and testament of Diarmaid Ó Conchobhair, prior of Cluain Tuaiscirt na Sionna
Authors: Thornton Davıd E. 
Published: October 2024

AbstractIt was not common for members of religious orders in the late middle ages to make a last will and testament because profession as a regular removed their testamentary capacity. This article prints the Latin text of the testament of Brother Diarmaid Ó Conchobhair, prior of Cloontuskert na Sinna, O.S.A., County Roscommon, drawn up in 1462 and proved a year later in London, along with a translation. It also offers a discussion of the testament, including Ó Conchobhair's stated intention of going on pilgrimage to Rome, in the light of other evidence relating to both its testator and to the monastic orders in general in late medieval Ireland and England.
It's More About ‘We’ Than ‘I’: Employee-Supervisor Fit in Achievement Striving, Organizational Identification, and Employee Voice
Authors: Zheng Xiaotong (Janey) , Williams Michele , Wang Xiaoyu (Christina) , Liang Jian 
Published: October 2024

AbstractBy integrating the theory of purposeful work behavior with the person-environment (P-E) fit literature, we employ a bilateral approach to examine how employee-supervisor congruence in purposeful work striving (i.e., achievement striving) influences employee voice behavior via an internal motivation mechanism (i.e., organizational identification). Using polynomial regressions with response surface modeling, we analyze data from 827 employees and their 197 supervisors in two studies. The results show that achievement-driven employees are more likely to speak up when employee-supervisor achievement striving is congruent, regardless of whether it is high or low. Furthermore, employee-supervisor congruence in achievement striving enhances employees’ felt oneness with the organization and organizational identification, which in turn fuels their voice behavior. We conclude with theoretical and practical implications.
Will COVID-19 become mild, like a cold?
Authors: Shaw Stewart Patrick D. 
Published: October 2024

Abstract
Several recent studies conclude that an increase in the pathogenicity of SARS-CoV-2 cannot be ruled out. However, it should be noted that SARS-CoV-2 is a ‘direct’ respiratory virus – meaning it is usually spread by the respiratory route but does not routinely pass through the lymphatics like measles and smallpox. Providing its tropism does not change, it will be unique if its pathogenicity does not decrease until it becomes similar to common cold viruses. Ewald noted in the 1980s that respiratory viruses may evolve mildness because their spread benefits from the mobility of their hosts. This review examines factors that usually lower respiratory viruses’ severity, including heat sensitivity (which limits replication in the warmer lungs) and changes to the virus’s surface proteins. Other factors may, however, increase pathogenicity, such as replication in the lymphatic system and spreading via solid surfaces or faecal matter. Furthermore, human activities and political events could increase the harmfulness of SARS-CoV-2, including the following: large-scale testing, especially when the results are delayed; transmission in settings where people are close together and not free to move around; poor hygiene facilities; and social, political, or cultural influences that encourage sick individuals to remain active, including crises such as wars. If we can avoid these eventualities, SARS-CoV-2 is likely to evolve to be milder, although the timescale is uncertain. Observations of influenza-like pandemics suggest it may take around two decades for COVID-19 to become as mild as seasonal colds.
Feeling the distance: The relationship between emotion regulation and spatial ability in childhood
Authors: Flouri Eirini , Tsomokos Dimitris I. 
Published: October 2024

Abstract
Research has shown experimentally that if children are taught to use language to create distance (socially, physically, and temporarily) when they revisit a potentially traumatic experience they reduce the intensity of their emotions. Building on this, this study was carried out to explore whether children with better spatial skills are better at such downregulation because of their very aptitude in understanding the concept of distance. Using data from a general-population birth cohort in the UK, the study examined the bidirectional association between emotional dysregulation and spatial ability among children aged 5 and 7 years. The findings reveal a significant reciprocal relationship even after adjusting for family, contextual, and individual confounders including verbal ability: spatial skills at age 5 years were inversely related to emotional dysregulation at age 7 years, and conversely, greater emotional dysregulation at age 5 years was associated with poorer spatial ability at age 7 years. The two paths were equally strong and there was no evidence of differences between them on the basis of sex. Our results suggest that enhancing spatial abilities could be a potential avenue for supporting emotion regulation in middle childhood.
Analysis of high-risk human papillomavirus infections and cervical intraepithelial neoplasia: factors influencing awareness among women of childbearing age in southwest China
Authors: Ning Kexue , Gong Jing , Li Xianghua , He Lijuan 
Published: October 2024

Abstract

Background:
High-risk Human Papillomavirus (HPV) infections are a leading cause of cervical diseases among Han Chinese women of reproductive age. Despite studies like Mai et al. (2021) addressing HPV prevalence in Southern China, awareness remains low, especially in Southwest China. Our study addresses this gap.

Objective:
This hospital-based, retrospective study analyzes the prevalence of high-risk HPV and its association with cervical intraepithelial neoplasia (CIN) among Han Chinese women of reproductive age in Southwest China.

Methods:
Data were collected from 724 women undergoing routine health exams from December 2022 to April 2023. A total of 102 women with high-risk HPV infections were identified. A survey assessed HPV awareness, CIN incidence, and socio-demographic factors influencing awareness.

Results:
Of the 724 women, 102 (14.1%) were diagnosed with high-risk HPV, with HPV-16 being the most common subtype (22.5%). Awareness was significantly lower among unmarried women (OR: 6.632, p = 0.047), those with high school education or less (OR: 20.571, p = 0.003), and rural residents (OR: 19.483, p = 0.020). HPV-16 was detected in 54.55% of women with high-grade CIN.

Conclusion:
There is an urgent need for targeted education and HPV vaccination in Southwest China, particularly for women with lower education, rural residents, and older individuals. Subtype-specific strategies are essential for preventing and managing CIN.
Clinical characteristics and outcomes of COVID-19 in pediatric patients with rheumatic diseases
Authors: Wang Yating , Su Shu , Ma Mingsheng , Weng Ruohang , Zhang Zhiyong , Liu Dawei , Yan Xin , Wang Junjun , Wang Yajun , Zhang Wei , Yang Sirui , Zhang Hongxia , Zhao Dongmei , Lu Meiping , Li Xiaoqing , Zhu Jia , Zhang Weixi , Yu Haiguo , Zhang Dongfeng , Huang Yanjie , Nong Guangmin , Cai Xuxu , Mao Huawei , Sun Fei , Wu Xiaochuan , Rong Zanhua , Zhang Jianjiang , Li Zhixiang , Jiang Xinhui , Li Xiaozhong , Liu Xuemei , Li Chongwei , Sun Lifeng , Gao Sihao , Yang Jun , Song Hongmei , Tang Xuemei ,   Chinese Alliance of Pediatric Rheumatic and Immunologic Diseases
Published: October 2024

Abstract
Background
This study investigates the clinical characteristics and outcomes of pediatric patients with rheumatic diseases infected with COVID-19 in China.

Methods
We conducted a retrospective analysis of pediatric patients with rheumatic diseases who contracted COVID-19. Data were collected via a comprehensive questionnaire with a 14-day follow-up. Multivariable logistic regression was used to assess severe outcomes, and network analyses evaluated symptom correlations.

Results
A total of 1070 cases were collected. Fever (88.05%) and cough (62.75%) were the most common symptoms. Cough, nasal congestion, and runny nose exhibited a stronger correlation with each other. A higher incidence of fever reduced the incidence of two single symptoms (nasal congestion [r = −0.833], runny nose [r = −0.762]). Vaccinated children showed a shorter time to negative COVID-19 conversion (7.21 days vs. 7.63 days, p < 0.05) and lower hospitalization rates (p = 0.025). Prolonged symptom duration was associated with older age (OR: 1.07 [1.04–1.11]; p < 0.001) and systemic lupus erythematosus (OR: 1.47 [1.01–2.12]; p = 0.046).

Conclusions
Pediatric patients with rheumatic diseases exhibited a wide range of clinical symptoms after COVID-19 infection. The infection generally did not lead to severe outcomes in this study. COVID-19 vaccination was associated with reduced hospitalization risk and expediting the time to negativity for virus.

Impacts
This manuscript demonstrates a comprehensive analysis of the clinical characteristics and outcomes of COVID-19 infection in pediatric patients with rheumatic diseases in China. It provides critical insights into the specific challenges faced by this vulnerable population and offers practical recommendations for improving patient management during periods of increased infectious risk.
Detection and isolation of brain tumors in cancer patients using neural network techniques in MRI images
Authors: Mir Mahdi , Madhi Zaid Saad , Hamid AbdulHussein Ali , Khodayer Hassan Al Dulaimi Mohammed , Suliman Muath , Alkhayyat Ahmed , Ihsan Ali , LU Lihng 
Published: October 2024

AbstractMRI imaging primarily focuses on the soft tissues of the human body, typically performed prior to a patient's transfer to the surgical suite for a medical procedure. However, utilizing MRI images for tumor diagnosis is a time-consuming process. To address these challenges, a new method for automatic brain tumor diagnosis was developed, employing a combination of image segmentation, feature extraction, and classification techniques to isolate the specific region of interest in an MRI image corresponding to a brain tumor. The proposed method in this study comprises five distinct steps. Firstly, image pre-processing is conducted, utilizing various filters to enhance image quality. Subsequently, image thresholding is applied to facilitate segmentation. Following segmentation, feature extraction is performed, analyzing morphological and structural properties of the images. Then, feature selection is carried out using principal component analysis (PCA). Finally, classification is performed using an artificial neural network (ANN). In total, 74 unique features were extracted from each image, resulting in a dataset of 144 observations. Principal component analysis was employed to select the top 8 most effective features. Artificial Neural Networks (ANNs) leverage comprehensive data and selective knowledge. Consequently, the proposed approach was evaluated and compared with alternative methods, resulting in significant improvements in precision, accuracy, and F1 score. The proposed method demonstrated notable increases in accuracy, with improvements of 99.3%, 97.3%, and 98.5% in accuracy, Sensitivity and F1 score. These findings highlight the efficiency of this approach in accurately segmenting and classifying MRI images.
Myocardial inflammatory cells in cardiac amyloidosis
Authors: Simon Philip , Behrens Hans-Michael , Kristen Arnt , Röcken Christoph 
Published: October 2024

AbstractBackground: Immunoglobulin derived AL amyloidosis and transthyretin derived ATTR amyloidosis are the most common forms of cardiac amyloidosis. Both may present with cardiac arrhythmias, heart failure, and extracardiac symptoms. Disease outcome is often fatal. Recently, it was proposed that amyloid may cause cardiac inflammation. Here we tested the hypothesis that immune cell infiltration in cardiac tissue correlates with clinicopathological patient characteristics. Patients and methods: Myocardial biopsies from 157 patients with cardiac amyloidosis (46.5% AL, 53.3% ATTR) were immunohistochemically assessed for the presence and amount of T lymphocytes (CD3), macrophages (CD68) and neutrophils (MPO). Amyloid load, cardiomyocyte diameter, apoptosis (Caspase 3), necrosis (complement 9), and various clinical parameters were assessed and correlated with immune cell density. Results: Myocardial tissue was infiltrated with T lymphocytes (CD3), macrophages (CD68) and neutrophils (MPO) with variable amounts. Significant correlations were found between the number of macrophages and NYHA class. No correlations were found between the presence and amount of T lymphocytes, neutrophils and clinicopathological patient characteristics. Conclusion: The significant correlation between cardiac macrophage density and heart failure points towards a significant role of macrophages in disease pathology.
Comparative analysis of microwave radiation generated by the interaction between electron beam and plasma under different methods
Authors: Gao Shen , Liu Jing-Xin , Zhang Jin-Ke 
Published: October 2024

AbstractThis article presents a physical model that describes the interaction between surface electron beams and plasma. The dispersion relations for beam plasma interactions were derived using perturbation method and field matching methods. The study investigates how different parameters affect radiation frequency and bandwidth. The results indicate that as electron beam velocity increases, the associated kinetic energy also rises, leading to an increase in both the maximum radiation frequency and bandwidth at high frequencies. Conversely, the radiation bandwidth at low frequencies decreases. Similarly, a higher plasma density results in a greater maximum radiation frequency, but the high-frequency bandwidth decreases, while the low-frequency bandwidth increases. Additionally, when the electron density and electron velocity of the electron beam remain constant, increasing the plasma density can increase the microwave radiation frequency However, there exists a plasma density threshold, beyond which high-frequency electromagnetic waves are no longer radiated.
Neue Methode zur portablen Muskelanalyse mittels Ultraschall
Authors: Rosahl Sophie C. , Rittweger Jörn 
Published: October 2024

ZUSAMMENFASSUNGBei Langzeitaufenthalten in Mikrogravitation unterliegt die Muskulatur einer Dekonditionierung. Das Training an Bord der International Space Station ermöglicht bereits eine zügige Aufnahme der täglichen Aktivitäten nach der Landung, jedoch kommt es nach wie vor zu beobachtbarer Muskelatrophie. Daher ist eine Analyse des Muskels von physiologischer sowie von struktureller Seite vor, während und nach Raumflügen von höchster Relevanz. Eine nichtinvasive, platz- und kosteneffiziente Methode ist dabei der muskuloskelettale Ultraschall. Die Echointensität kann Aufschlüsse über die Binnenqualität des Muskels geben, jedoch sind die Ergebnisse stark untersucherabhängig. Durch Modellierung einer Funktion basierend auf Messungen des Schallwinkels und der Echointensität konnten objektivere Parameter erschlossen werden. Damit lassen sich in Zukunft Echointensitäten zwischen Muskeln vergleichen oder deren Verlauf über eine Periode der Immobilisierung verfolgen, um pathologischen Veränderungen frühzeitig und gezielt entgegenzuwirken.
Evaluating endoscopic ultrasound-guided tissue acquisition for diagnosis of small pancreatic neuroendocrine neoplasms
Authors: Katsuda Hiromune , Kobayashi Masanori , Ito Go , Kawamoto Ami , Krimura Susumu , Sato Hiroyuki , Hirakawa Akihiro , Akahoshi Keiichi , Kudo Atsushi , Ohtsuka Kazuo , Okamoto Ryuichi 
Published: October 2024

Abstract
Background and study aims Although small hypervascular tumors are suspected to be pancreatic neuroendocrine tumors (p-NENs), their diagnosis and treatment are challenging. This study evaluated the usefulness of endoscopic ultrasound-guided tissue acquisition (EUS-TA) for diagnosis of small p-NENs.
Methods All p-NEN lesions that underwent EUS-TA at our hospital between April 2018 and December 2023 were retrospectively analyzed. The diagnostic sensitivity of EUS-TA and the concordance rate of grading with EUS-TA and surgical specimens were examined. The lesions were grouped by size.
Results The diagnostic sensitivity of EUS-TA was analyzed for 82 lesions, of which 44 were compared with postoperative specimens for grading. The definitive diagnosis was neuroendocrine tumor (NET) in 75 lesions, neuroendocrine carcinoma in five lesions, and mixed neuroendocrine non-neuroendocrine neoplasm in two lesions. Thirty tumors were ≤10 mm, 30 were 10 to 20 mm, and 22 were >20 mm, and the diagnostic sensitivities were 96.7%, 96.7%, and 90.9%, respectively. Concordance rates for grading were 94.4%, 82.4%, and 77.8% for tumors ≤10 mm, 10 to 20 mm, and ≥20 mm, respectively, with Cohen’s kappa coefficients of 0.64, 0.48, and 0.40, respectively.
Conclusions EUS-TA showed adequate diagnostic sensitivity and grading agreement for p-NENs of all sizes, allowing for determination of appropriate treatment.
The 2024 European Society of Cardiology Guidelines for Diagnosis and Management of Atrial Fibrillation: A Viewpoint from a Practicing Clinician's Perspective
Authors: Potpara Tatjana , Romiti Giulio F. , Sohns Christian 
Published: October 2024

AbstractAtrial fibrillation (AF) is a complex disease requiring a multidomain and (usually) long-term management, thus posing a significant burden to patients with AF, practitioners, and health care system. Unlike cardiovascular conditions with a narrow referral pathway (e.g., acute coronary syndrome), AF may be first detected by a wide range of specialties (often noncardiology) or a general practitioner. Since timely initiated optimal management is essential for the prevention of AF-related complications, a concise and simple guidance is essential for practitioners managing AF patients, regardless of their specialty. Guideline-adherent management of patients with AF has been shown to translate to improved patient outcomes compared with guideline-nonadherent treatment. To facilitate guideline implementation in routine clinical practice, a good guideline document on AF should introduce only evidence-based new recommendations, while avoiding arbitrary changes, which may be confusing to practitioners. Herein, we discuss the main changes in the 2024 European Society of Cardiology (ESC) AF Guidelines relative to the previous 2020 ESC document. Whether the updates and new recommendations issued by the new guidelines will translate in high adherence in clinical practice (and hence improved prognosis of patients with AF) will need to be addressed in upcoming years.
Brillouin laser pumped tunable low-threshold mid-IR Kerr comb at 2 μm
Authors: Pathak Kanad , Pant Ravi 
Published: October 2024

Optical frequency combs in the 2 μm wavelength region are important for applications ranging from sensing of gases such as CO2 and CO to optical communications, LIDAR, and gravitational wave detection. The development of low-loss waveguides and high-Q microresonators with anomalous dispersion and the availability of tunable narrow linewidth lasers around 1.55 μm have enabled the realization of small footprint soliton combs and low-threshold Kerr combs in this wavelength region; demonstrations of microresonator frequency combs in the 2 μm wavelength region have been limited. Here, we harness an intracavity pumping scheme to demonstrate a low-threshold (&lt;100 mW) microresonator Kerr comb at 2 μm. We exploit Brillouin lasing in a silica microsphere (∼310 μm diameter) to create an intracavity pump, which then generates a ∼140 nm wide Kerr comb in the backscattered Stokes direction. We demonstrate the tolerance of the comb generation scheme to microsphere dimensions and the input pump wavelength by achieving Kerr comb generation in microspheres of diameters ranging from 295 to 318 μm and also at different input pump wavelengths for a particular microsphere diameter. Intracavity pumping opens up opportunities for the development of soliton combs and Kerr combs in the mid-IR wavelength region for applications such as dual-comb spectroscopy, LIDAR, and optical communications.