bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoplasmic Reticulum Stress Contributes to the Loss of Newborn Hippocampal Neurons after Traumatic Brain Injury
Authors: Hood Kimberly N. , Zhao Jing , Redell John B. , Hylin Michael J. , Harris Brynn , Perez Alec , Moore Anthony N. , Dash Pramod K. 
Published: January 2018

Adult hippocampal neurogenesis has been shown to be required for certain types of cognitive function. For example, studies have shown that these neurons are critical for pattern separation, the ability to store similar experiences as distinct memories. Although traumatic brain injury (TBI) has been shown to cause the loss of newborn hippocampal neurons, the signaling pathway(s) that triggers their death is unknown. Endoplasmic reticulum (ER) stress activates the PERK-eIF2α pathway that acts to restore ER function and improve cell survival. However, unresolved/intense ER stress activates C/EBP homologous protein (CHOP), leading to cell death. We show that TBI causes the death of hippocampal newborn neurons via CHOP. Using CHOP KO mice, we show that loss of CHOP markedly reduces newborn neuron loss after TBI. Injured CHOP mice performed significantly better in a context fear discrimination task compared with injured wild-type mice. In contrast, the PERK inhibitor GSK2606414 exacerbated doublecortin cell loss and worsened contextual discrimination. Administration of guanabenz (which reduces ER stress) to injured male rats reduced the loss of newborn neurons and improved one-trial contextual fear memory. Interestingly, we also found that the surviving newborn neurons in brain-injured animals had dendritic loss, which was not observed in injured CHOP KO mice or in animals treated with guanabenz. These results indicate that ER stress plays a key role in the death of newborn neurons after TBI. Further, these findings indicate that ER stress can alter dendritic arbors, suggesting a role for ER stress in neuroplasticity and dendritic pathologies.SIGNIFICANCE STATEMENTThe hippocampus, a structure in the temporal lobe, is critical for learning and memory. The hippocampus is one of only two areas in which neurons are generated in the adult brain. These newborn neurons are required for certain types of memory, and are particularly vulnerable to traumatic brain injury (TBI). However, the mechanism(s) that causes the loss of these cells after TBI is poorly understood. We show that endoplasmic reticulum (ER) stress pathways are activated in newborn neurons after TBI, and that manipulation of the CHOP cascade improves newborn neuron survival and cognitive outcome. These results suggest that treatments that prevent/resolve ER stress may be beneficial in treating TBI-triggered memory dysfunction.
Lixboa revisitada ou o império retornado: a mito-poética da Mensagem (e uma saudade lusíada) n’As naus de Lobo Antunes
Authors: Bergamo Edvaldo , Medeiros Ana Clara Magalhães de 
Published: January 2018

A experiência histórica portuguesa pós-1974 propiciou a difusão de romances de notável arrojo ético-estético. As naus (1988), de António Lobo Antunes, é prosa que remete à tradição literária enformadora da cultura lusa, em que Os Lusíadas, de Camões, e a Mensagem, de Pessoa, são pilares para o estabelecimento de um grande diálogo mito-poético. Aliando mito e poesia, como propõe o teórico Northrop Frye, à noção de saudade, como traço português inerente (conforme Eduardo Lourenço e Teixeira de Pascoaes), este artigo propõe um estudo comparado do romance de Lobo Antunes especialmente à Mensagem (1934): um encadeamento que impele a revisitação ao icônico épico de Camões. Recorrendo-se, ainda, aos conceitos de romance histórico, de György Lukács, e de dialogismo, de Mikhail Bakhtin, o trabalho amplifica discussões suscitadas pelo romance em causa: a tensão entre a história hegemônica e a vida comum, a tradição literária e os impasses político-sociais do século XX.********************************************************************Lixbon revisited or the returned empire: the mythopoetic of Mensagem (and a miss of lusiads) in As Naus by Lobo AntunesThe Portuguese experience after 1974 propitiated a diffusion of notable boldness ethic-aesthetic novels. As Naus (1998), written by Lobo Antunes, is a prose that remit to the literary tradition of the Portuguese cultural form, in which Lusíadas, by Camões, and Mensagem, by Pessoa, are the pillars to the establishment of a major myth-poetic dialogue. Combining myth and poetry, as proposes the theorist Frye, the notion of saudade [yearning], as an inerent Portuguese feature (according to Lourenço and Pascoaes), we propose a comparated study in the romance of Antunes, especially to the Mensagem (1934): a chaining that drives the revisitation to the iconic Epic of Camões. Recurring to the concepts of the historical novel, by Lukács, and the dialogic of Bakhtin, this document amplifies the discussions instilled by the novel in cause: the tension between hegemoniacal history and common life, the literary tradition and the political stalemates of the XX century. Keywords: Lobo Antunes; Pessoa; Camões; Portuguese Historical Contemporary Novel
The validation of Implicit Association Test measures for smartphone and Internet addiction in at-risk children and adolescents
Authors: Roh Daeyoung , Bhang Soo-Young , Choi Jung-Seok , Kweon Yong Sil , Lee Sang-Kyu , Potenza Marc N. 
Published: January 2018

Background
Potential concerns are increasing that smartphone and Internet addictions may have deleterious effects on the mental health. Despite the recognition of the important role that implicit associations may have over explicit processes in addiction, such implicit associations have not been comprehensively investigated with respect to Internet addiction. Therefore, we modified the Implicit Association Test (IAT) for smartphone and Internet addictions and investigated its validity in children and adolescents.

Methods
In this experimental study, 78 at-risk children and adolescents ranging in age from 7 to 17 years completed an IAT modified with pictures captured from the most popular Internet games among youth. Furthermore, measures of Internet and smartphone addictions, mental health and problem behaviors, impulsive tendencies, self-esteem, daily stress, and quality of life were assessed simultaneously.

Results
Significant correlations were found between IAT D2SD scores and standardized scales for Internet (r = .28, p < .05) and smartphone (r = .33, p < .01) addictions. There were no significant correlations between IAT parameters and other scales measuring the constructs that are less relevant to the features of addiction, such as daily stress levels, impulsivity, and quality of life. Multiple regression analysis revealed that the IAT D2SD was independently and positively associated with smartphone addiction (p = .03) after controlling for other clinical correlates.

Conclusions
This study demonstrated good convergent and discriminant validity of this IAT as a novel measurement relating to Internet and smartphone addictions. Further longitudinal and prospective studies are needed to evaluate its potential utility in clinical and community settings.
A magyar egészségügyi forráselosztás vizsgálata az angliai módszerrel
Authors: Fadgyas-Freyler Petra 
Published: January 2018

Abstract: Introduction and aim: This paper describes both the English health resource allocation and the attempt of its Hungarian adaptation. Method: We describe calculations for a Hungarian regression model using the English ‘weighted capitation formula’. Results: The model has proven statistically correct. New independent variables and homogenous regional units have to be found for Hungary. Conclusion: The English method can be used with adequate variables. Hungarian patient-level health data can support a much more sophisticated model. Further research activities are needed. Orv Hetil. 2018; 159(5): 183–191.
A boka-kar index oszcillometriás elven működő meghatározásának helye a klinikai gyakorlatban
Authors: Járai Zoltán , Kolossváry Endre , Szabó Ildikó , Kiss István , Farsang Csaba , Farkas Katalin 
Published: January 2018

Abstract: Introduction: Oscillometric devices in contrast to the traditional Doppler based method for ankle-brachial index measurements have promising advantages like no need for special training, faster performance, and operator independence. Aim: Comparative assessment of the oscillometric and Doppler-based ankle-brachial index measurement. Method: Ankle-brachial index measurements were performed by continuous wave Doppler and an automatic oscillometric device (BOSO ABI-system 100) in consecutive subjects. The comparative assessment was performed by Bland−Altman and ROC analysis. Results: The two kinds of measurements (734 measurements) showed a good agreement in the ankle-brachial index spectrum close to the cut-off value of 0.9. The agreement diminished below or above this value. The optimal oscillometric ankle-brachial index diagnostic cut-off value was 0.96. Conclusions: The oscillometric device is not interchangeable for Doppler devices in the whole ankle-brachial index spectrum. Nevertheless, owing to its discriminative power, the oscillometric measurement potentially has an efficient role in the screening of asymptomatic patients. Orv Hetil. 2018; 159(5): 176–182.
Progresszív kórlefolyást mutató szisztémás mastocytosis
Authors: Várkonyi Judit , Szombath Gergely , Vályi-Nagy Anna , Csomor Judit , Egedi Krisztina , Kovalszky Ilona , Tölgyesi Katalin , Szerafin László , Tóth László , Soós Györgyi , Masszi Tamás 
Published: January 2018

Abstract: Authors report on a case of a male patient of systemic mastocytosis that was associated with extensive cutaneous lesions. Chronic diarrhoea worsening his quality of life was well managed by the administration of antihistamines. The pleural fluid recurrence soon after drainage has been controlled by the administration of alpha interferon. 40 years after the onset of the first skin signs progression has been manifested in the development of “B” (bone marrow infiltration rate >30%, dysmyelopoiesis, serum tryptase >20 μg/L, hepato- and splenomegaly) and “C” symptoms (liver function test abnormalities, cytopenia, malabsorption, osteoporosis). The patient died at age of 87. The authors’ aim was to attract attention on this rare disease and emphasize that symptomatic therapy with antihistamines and drugs available based on customised rights by the National Health Insurance Fund might provide good quality of life. Orv Hetil. 2018; 159(5): 192–196.
Penerapan Model-Model Permainan Untuk Meningkatkan Partisipasi Siswa Pada Pembelajaran Aktivitas Permainan Rounders
Authors: Fikri Ikbal Kemal 
Published: January 2018

Penelitian ini bertujuan untuk mengungkapkan apakah penerapan model-model permainan pada pembelajaran aktivitas permainan rounders dalam pembelajaran pendidikan jasmani dapat meningkatkan partisipasi siswa. Penelitian dilaksanakan dengan metode penelitian tindakan kelas yang terdiri atas tahapan perencanaan tindakan, pelaksanaan tindakan, observasi dan refleksi. Data dikumpulkan dengan menggunakan instrumen observasi partisipasi. Semua data yang terkumpul dianalisis menggunakan teknik prosentase, nilai partisipasi siswa pada observasi pra-siklus 19%, kemudian setelah dilakukan penelitian pada siklus 1 nilai partisipasi siswa 53% mengalami kenaikan 34% pada siklus 1, kemudian pada siklus 2 nilai partisipasi siswa 84% mengalami kenaikan 31%. Berdasarkan hasil analisis data tersebut, dapat disimpulkan bahwa melalui penerapan model permainan pada pembelajaran aktivitas permainan rounders dalam pembelajaran pendidikan jasmani dapat meningkatkan partisipasi siswa.
Extracting Association Rules from Turkish Otorhinolaryngology Discharge Summaries
Authors: OĞUZ YOLCULAR Başak , BİLGE Uğur , SAMUR Mehmet Kemal 
Published: January 2018

The objectives of this study were to structure
otorhinolaryngology discharge summaries with text mining methods and analyze
structured data and extract relational rules using Association Rule Mining
(ARM). In this study, we used otorhinolaryngology discharge notes. We first
developed a dictionary-based information extraction (IE) module in order to
annotate medical entities. Later we extracted the annotated entities, and
transformed all documents into a data table. We applied ARM Apriori algorithm
to the final dataset, and identified interesting patterns and relationships
between the entities as association rules for predicting the treatment
procedure for patients. The IE module’s precision, recall, and f-measure were
95.1%, 84.5%, and 89.2%, respectively. A
total of fifteen association rules were found by selecting the top ranking
rules obtained from the ARM analysis. These fifteen rules were reviewed by a
domain expert, and the validity of these rules was examined in the PubMed
literature. The results showed that the association rules are mostly endorsed
by the literature. Although our system focuses on the domain of
otorhinolaryngology, we believe the same methodology can be applied to other
medical domains and extracted rules can be used for clinical decision support
systems and in patient care.
Çoklu Görüntü Damgalama Yönteminde Farklı Frekans Bölgelerinin Değerlendirilmesi
Authors: ABDULRAHMAN Ahmed Khaleel , ÖZTÜRK Serkan 
Published: January 2018

Son yıllarda
internet ve mobil teknolojilerin gelişmesi ile birlikte, çoklu-ortam
dokümanlarının telif hakkının korunması önem kazanmıştır. Sayısal görüntü ve
video gibi çoklu-ortam dokümanlarının korunmasında sayısal damgalama en çok kullanılan
yöntem olmuştur. Bu çalışmada, Ayrık Kosinüs Dönüşümü, Ayrık Dalgacık Dönüşümü
(ADD) ve Arnold Dönüşümü kullanılarak gri-seviyeli görüntü damgalama yöntemi
önerilmiştir. Bu damgalama yönteminde eklenecek damgalar dört eşit parçalara
ayrılmıştır. Saldırılara karşı damgalama yönteminin dayanıklılığını artırmak
için bu parçaların her biri damga eklenecek görüntülerin ADD işlemi sonucunda
elde edilen dört ayrı bantlarının farklı alt bölgelerine gizlenmiştir. ADD
frekans uzayında farklı alt bölgelere damga ekleme işleminde önerilen
gri-seviyeli damgalama yönteminin başarımı damgalanmış görüntülere doğrusal ve
doğrusal olmayan saldırılar uygulanarak değerlendirilmiştir. Bu çalışmada
ayrıca önerilen yöntem ile temel alçak frekans bandına damga ekleme yöntemi karşılaştırılmıştır.
Deneysel sonuçlar önerilen yöntemin saldırılara karşı dayanıklı olduğunu
göstermiştir. Bununla birlikte damgalanmış görüntülerin kalitelerinin korunduğu
da görülmüştür.
A STUDY OF LOCAL ARTISAN AND CRAFTSMAN MARKET OPERATION IN REZEKNE
Authors: Znotina Daina , Igavens Maris 
Published: January 2018

Local food, both from the perspective of the producer and the consumer, is becoming all the more popular topic in modern society. One of the places where the buyers and sellers of these products meet is the market. The research aim is to study the operation of local artisan and craftsman markets in Rezekne and the opportunities for improving their operation. The theoretical and practical aspects of artisan activity are described in the study; surveys have been conducted to find out the opinions of market visitors on the supply of the artisan market; data analysis and interpretation; and to make conclusions and suggestions for improving the operation of the local artisan and craftsman market in Rezekne. Research methods: logical construction, analysis, a survey, the graphical method. The study results in a conclusion that the buyers of the local artisan and craftsman market in Rezekne are satisfied with the supply; however there are opportunities for its improvement. The main aspects with the opportunities for improvement are: spreading information about the market, i.e. its advertisement, expanding the assortment offered, extending the opening hours of the market, expanding the premises and the parking space of the market.
Characteristics of Green Seaweeds from Seribu Islands and Sekotong West Nusa Tenggara Antioxidant
Authors: Nufus Chairun , Nurjanah N. , Abdullah Asadatun 
Published: January 2018

Green seaweeds contain many bioactive compounds which one of them act as antioxidants as well as rich in fibers and essential minerals. This study was aimed to determine physicochemicals properties of Caulerpa lentillifera, Halimeda opuntia and Ulva lactuca and as well as their antioxidant activities. Research consists of proximate analysis, mineral composition, phytochemical compounds, heavy metal content and<br />antioxidant activity of extract green seaweed by CUPRAC, DPPH and FRAP method. The results of the study macronutrient analysis shows the moisture content ranged from 10.83% to 28.41%, ash 24.97% to 70.66%, fat 3.80% to 5.26%, fiber 2.63% to 3.86%, protein 0.18% to 1.43% and carbohydrate 10.69% to 36.49%. Mineral Ca C. lentillifera, H. opuntia and U. lactuca about 17, 95-124,39 g/kg, Fe 0,13-0,34 g/kg,<br />K 2,29-12,28 g/kg, Mg 2.63-22.23 g/kg and Na 21.16-34.18 g/kg. The heavy metals content of C. lentillifera, H. opuntia and U. lactuca ranged in Pb 13.57 mg/kg to 37.76 mg/kg, Cu 5.02 mg/kg to 8.32 mg/kg and Hg 0.170 mg/kg to 0.265 mg/kg. Phytochemicals properties of C. lentillifera, H. opuntia and U. lactuca were<br />alkaloids, flavonoids, phenols hydroquinone, saponins, steroids and triterpenoids. Antioxidant activity of ethanol extract DPPH showed IC50 values ranged from 1.6–4 445 mg /L, CUPRAC 138.21–212.43 μmol trolox/g extract, FRAP 175.93–181.79 μmol trolox/g extract. <br /><br />
Validation of new indices for differentiation between iron deficiency anemia and beta thalessemia trait, a study in pregnant females
Authors: Arora Sheetal , Rana Deepshikha , Kolte Sachin , Dawson Leelawathi , Dhawan Indrani 
Published: January 2018

<p class="abstract"><strong>Background:</strong> The two most frequent types of microcytic hypochromic anemia in developing countries are beta thalassemia trait (𝛽-TT) and iron deficiency anemia (IDA). Several indices using blood cell count parameters have been suggested to differentiate between two. In this study we evaluated the reliability of three indices.</p><p class="abstract"><strong>Methods:</strong> The present cross-sectional study was carried out in 300 pregnant females in third trimester. Out of these, 90 microcytic hypochromic females were selected. Mentzers index, red cell distribution width index and Matos and Carvalho index (MCI) were calculated from the regular 3-part analyser haematological parameters. </p><p class="abstract"><strong>Results:</strong> The Mentzer index was the most reliable index, as it had the highest sensitivity (97.62%), specificity (66.67%), and Youden’s index (64%) for detecting Iron deficiency anaemia; the Matos and Carvalho Index showed higher sensitivity (98.81%)but a much lower specificity (33.3%) and Youden’s index (32%) while the red cell distribution width index showed the sensitivity and specificity of 92.86% and 66.67%, respectively with Youden’s index of 59%.</p><p class="abstract"><strong>Conclusions:</strong> The Mentzer index provided the highest reliabilities for differentiating<strong> </strong>IDA from 𝛽-TT. The new indices have high sensitivities and positive predictive value for identifying IDA, making them useful for screening population at risk. </p>
Diclofenac--Acetaminophen Combination Induced Acute Kidney Injury In Postoperative Pain Relief
Authors: Zhu Yan , Xu Ping , Wang Qing , Luo Jian-quan , Xiao Yi-wen , Li Yi-yi , Zhou Yan-gang , Cave Andrew , Banh Hoan Linh 
Published: January 2018

Purpose: The objective of this study was to determine: 1) the incidence and the risk factors of diclofenac/acetaminophen combination as a single agent induced Acute Kidney Injury (AKI) in postoperative pain relief 2) the average cost and length of hospital stay for patients in AKI group and non-AKI group. Methods: All patients with no prior history of chronic kidney disease (CKD) and normal serum creatinine [44~130 μmol /l] who received diclofenac and acetaminophen combination as a single agent intramuscularly (IM) between January and December 2015 in The Second Xiangya Hospital, Changsha, Hunan, China were included in this retrospective own-control study. Baseline serum creatinine (SCr) and SCr during NSAID use were collected. AKI is defined as an increased of Scr over 1.5 times the baseline. Multivariate analyses were performed with a logistic regression model to assess the significant risk factors of AKI. Results: A total of 821 patients were included in the study with 63 [7.7%] patients had diclofenac/acetaminophen combination single agent induced AKI. Multivariate analysis confirmed that using diclofenac/acetaminophen combination after surgeries within 24 h were significantly associated with AKI [odds ratio, OR, 2.173; 95% CI, 1.113-4.243; P=0.023]. The average cost and length of hospitalization in AKI group was 1.87 times [p=0.000] and 1.2 times [p=0.043] comparison than non-AKI group, respectively. Conclusions: The incidence of diclofenac/acetaminophen combination single agent induced AKI in postoperative pain relief was 7.7%. Patients with hypertension or liver cirrhosis was more likely to develop AKI and using diclofenac/acetaminophen combination after surgeries within 24 h was significant risk factors for AKI. AKI prolonged the cost and length of hospitalization. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
İzmir’de Yetiştirilen Satsuma (mandalina) ve Antalya’da Yetiştirilen Narlarda Akdeniz Meyve Sineği [Ceratitis capitata (Wiedemann) (Diptera: Tephritidae)] Mücadelesinde Kullanılan İnsektisitlerin Kalıntı Analizi
Authors: DİNÇAY Orhan , CİVELEK Hasan Sungur , GÖRMEZ Emrah 
Published: January 2018

&nbsp;

Bu&nbsp;çalışma ile ülkemizde Akdeniz Meyve Sineği [Ceratitis
capitata (Wiedemann) (Diptera: Tephritidae)]’ne karşı İzmir ilinde satsuma
mandalinaları ve &nbsp;&nbsp;&nbsp;&nbsp;Antalya ilindeki
narlarda uygulanan insektisitlerin kalıntılarının belirlenmesi hedeflenmiştir.
Numuneler EN 15662 QuEChERS metoduna göre ekstrakte edilip LC/MSMS ve GC/MSMS
cihazlarında analiz edilmiştir. Kalıntı analizlerinde numunelerde tespit
limitleri üzerinde (0.005 mg/kg) malathion, spinosad, tau-fluvalitate,
esfenvalerate ve deltamethrin etken maddelerine rastlanmıştır. Satsuma
mandalina numunesi analiz sonuçlarından, 2013 yılında dört numunede, 2014
yılında yedi numunede malathion kalıntı değerleri MRL üzerinde bulunmuştur.
Ayrıca 2014 verilerine göre satsuma numunelerinde kullanılan insektisitlerden
tau-fluvalinate, esfenvalerate ve deltamethrinin turunçgilde Akdeniz Meyve
Sineği’ne karşı ruhsatı bulunmamaktadır. Yine bu verilere göre deltamethrin haricinde
kullanılmış bütün insektisitlerin de narda Akdeniz Meyve Sineği’ne karşı
ruhsatı bulunmamaktadır.