bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supporting Carers: Study Protocol of a Meta-Review of Psychosocial Interventions for Carers of People With Cancer
Authors: Nic Giolla Easpaig Brona , Newman Bronwyn , Johnson Judith , Laidsaar-Powell Rebekah , Sansom-Daly Ursula M , Jones Lucy , Hofstätter Lukas , Robertson Eden G , Mears Stephen , Sattarshetty Kabir , Harrison Reema 
Published: September 2024

Background
While there is a clear need for psychosocial interventions that promote the well-being of carers of patients with cancer, the corresponding evidence base is disparate, complex, and difficult for end users to navigate and interpret. Carers remain undersupported with a lack of dedicated, effective, evidence-based programs. We will conduct a meta-review to synthesize this evidence and determine the state of science in this field.

Objective
This study aims to address the question, “what psychosocial interventions are available to promote the well-being of carers for people with cancer?”

Methods
A meta-review will synthesize the relevant reviews of psychosocial interventions that have been developed and evaluated with carers for people with cancer. A total of 4 electronic databases (PsycInfo, MEDLINE, CINAHL, and Cochrane Database of Systematic Reviews) will be searched for reviews published between January 2013 and December 2023. A team-based approach will be taken for screening and assessment of the returned records against the eligibility criteria to determine inclusion. Included reviews will be critically appraised using the Joanna Briggs Institute Critical Appraisal Checklist for Systematic Reviews and Research Syntheses. Relevant data on study characteristics, carer and patient populations, intervention details, and psychosocial outcomes will be extracted, synthesized, and the findings will be presented in a narrative format.

Results
It is anticipated that the study will be completed by October 2024.

Conclusions
Ensuring that carers have access to evidence-based programs that promote their well-being as they care for loved ones is critical. This meta-review will contribute to program development and translation efforts by providing a clear picture of the intervention evidence base of carers of patients with cancer and identifying notable strengths, weaknesses, and gaps across the literature. The findings are anticipated to offer future directions to advance research in the field.

Trial Registration
PROSPERO (CRD42023403219); https://tinyurl.com/4tnzv49s

International Registered Report Identifier (IRRID)
DERR1-10.2196/56403
Personality and Health-Related Quality of Life of Older Chinese Adults: Cross-Sectional Study and Moderated Mediation Model Analysis
Authors: Dong Xing-Xuan , Huang Yueqing , Miao Yi-Fan , Hu Hui-Hui , Pan Chen-Wei , Zhang Tianyang , Wu Yibo 
Published: September 2024

Abstract

Background
Personality has an impact on the health-related quality of life (HRQoL) of older adults. However, the relationship and mechanisms of the 2 variables are controversial, and few studies have been conducted on older adults.

Objective
The aim of this study was to explore the relationship between personality and HRQoL and the mediating and moderating roles of sleep quality and place of residence in this relationship.

Methods
A total of 4123 adults 60 years and older were from the Psychology and Behavior Investigation of Chinese Residents survey. Participants were asked to complete the Big Five Inventory, the Brief version of the Pittsburgh Sleep Quality Index, and EQ-5D-5L. A backpropagation neural network was used to explore the order of factors contributing to HRQoL. Path analysis was performed to evaluate the mediation hypothesis.

Results
As of August 31, 2022, we enrolled 4123 older adults 60 years and older. Neuroticism and extraversion were strong influencing factors of HRQoL (normalized importance >50%). The results of the mediation analysis suggested that neuroticism and extraversion may enhance and diminish, respectively, HRQoL (index: β=−.262, P<.001; visual analog scale: β=−.193, P<.001) by increasing and decreasing brief version of the Pittsburgh Sleep Quality Index scores (neuroticism: β=.17, P<.001; extraversion: β=−.069, P<.001). The multigroup analysis suggested a significant moderating effect of the place of residence (EQ-5D-5L index: P<.001; EQ-5D-5L visual analog scale: P<.001). No significant direct effect was observed between extraversion and EQ-5D-5L index in urban older residents (β=.037, P=.73).

Conclusions
This study sheds light on the potential mechanisms of personality and HRQoL among older Chinese adults and can help health care providers and relevant departments take reasonable measures to promote healthy aging.
Psychological Interventions and Those With Elements of Positive Psychology for Child and Youth Mental Health During the COVID-19 Pandemic: Literature Review, Lessons Learned, and Areas for Future Knowledge Dissemination
Authors: Lyzwinski Lynnette , Zwicker Jennifer D , Mcdonald Sheila , Tough Suzanne 
Published: September 2024

Background
There was a marked decline in child and teenage mental health worldwide during the pandemic, with increasing prevalence of depression, anxiety, and suicide. Research indicates that positive psychological interventions may be beneficial for mental health.

Objective
The aims of this review were to evaluate positive psychological interventions for child and youth mental health implemented during the COVID-19 pandemic and assess overall effectiveness for mental health and knowledge.

Methods
We undertook a literature search of PubMed, MEDLINE, and Google Scholar for all eligible studies on digital and hybrid in-person psychological interventions for youth mental health during the COVID-19 pandemic. A particular emphasis was placed on positive psychological interventions or interventions that had components of positive psychology, including gratitude, acceptance, positive emotions, or resilience building.

Results
A total of 41 interventions were included in this review. Most of the interventions were digital. Overall, most of the interventions assisted with one or more mental health or psychological indicators, such as depression, anxiety, posttraumatic stress disorder, stress, and resilience. However, findings were mixed when it came to targeting both depression and anxiety together. The interventions that promoted youth mental health most often had a range of diverse positive psychology components and were evidence based. Not all studies measured changes in mindfulness. Few studies examined knowledge acquired on mental health self-care, managing mental health problems, knowledge of positive psychological techniques, mindfulness knowledge, or mental health self-efficacy.

Conclusions
Diverse multicomponent interventions appear to assist with youth mental health overall, although their effects on both depression and anxiety are less clear. There is also a need for more research on knowledge gains to determine whether the interventions improved knowledge on mental health–supportive behaviors, which may be sustained beyond the intervention. Finally, more studies need to evaluate whether the interventions assisted with increasing self-efficacy for practicing positive psychological techniques as well as changes in mindfulness levels. Future studies should not only assess effectiveness for mental health outcomes but also assess knowledge translation, with valid measures of knowledge and self-efficacy for mental health–supportive behaviors and positive psychological skills acquired (eg, the ability to practice mindfulness).
Mobile App for Patients With Chronic Obstructive Pulmonary Diseases During Home-Based Exercise Care: Usability Study
Authors: Chien Shih-Ying 
Published: September 2024

Background
Digital health tools have demonstrated promise in the treatment and self-management of chronic diseases while also serving as an important means for reducing the workload of health care professionals (HCPs) and enhancing the quality of care. However, these tools often merely undergo large-scale testing or enter the market without undergoing rigorous user experience analysis in the early stages of their development, leading to frequent instances of low use or failure.

Objective
This study aims to assess the usability of and satisfaction with a mobile app designed for the clinical monitoring of patients with chronic obstructive pulmonary disease undergoing pulmonary rehabilitation at home.

Methods
This study used a mixed methods approach involving two key stakeholders—patients with chronic obstructive pulmonary disease and HCPs—across three phases: (1) mobile app mock-up design, (2) usability testing, and (3) satisfaction evaluation. Using convenience sampling, participants were grouped as HCPs (n=12) and patients (n=18). Each received a tablet with mock-ups for usability testing through interviews, with audio recordings transcribed and analyzed anonymously in NVivo12.0, focusing on mock-up features and usability insights. Task difficulty was rated from 1 (very easy) to 5 (very difficult), with noncompletion deemed a critical error. Usability satisfaction was measured on a 5-point Likert scale from 1 (strongly disagree) to 5 (strongly agree).

Results
The research indicated a notable difference in app usability perceptions: 66% (8/12) of HCPs found tasks “very easy,” compared to only 22% (4/18) of patients. Despite this, no participant made critical errors or withdrew, and satisfaction was high. HCPs completed tasks in about 20 minutes, while patients took 30. Older adults faced challenges with touch screens and scroll menus, suggesting the need for intuitive design aids like auditory support and visual health progress indicators, such as graphs. HCPs noted potential data delays affecting service, while non–native-speaking caregivers faced interpretation challenges. A secure pairing system for privacy in teleconsultations proved difficult for older users; a simpler icon-based system is recommended. This study highlights the need to consider stakeholder abilities in medical app design to enhance function implementation.

Conclusions
Most HCPs (11/12, 91%) found the app intuitive, though they recommended adding icons to show patient progress to support clinical decisions. In contrast, 62% (11/18) of patients struggled with tablet navigation, especially with connectivity features. To ensure equitable access, the design should accommodate older users with diverse abilities. Despite challenges, both groups reported high satisfaction, with patients expressing a willingness to learn and recommending the app. These positive usability evaluations suggest that, with design improvements, such apps could see increased use in home-based care.
Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Metformin HCl and Repaglinide in Pharmaceutical Formulation
Authors: Kharbade Sukanya , Asnani Alpana , Pratyush Kumar 
Published: September 2024

Objective: A new, simple, rapid, accurate and economical method have been developed for the simultaneous estimation of Metformin HCl and Repaglinide in formulation.
Method: The absorbances of both the drugs were determined at 238 nm and at 294 nm. The linearity was observed in the concentration range of 2-100 µg/ml and 1-35 µg/ml for Metformin HCl and Repaglinide respectively. The method was validated as per ICH guidelines.
Result: The recovery of Metformin and Repaglinide was found in the range of 98.24 ± 0.325 to 100.25 ± 0.756.
Conclusion: The proposed method was accurate, reproducible and economical and can be used successfully for quantitative estimation of Metformin HCl and Repaglinide in bulk and tablet dosage form.
Keyword:- Metformin, Repaglinide, UV- spectrophotometric method, simultaneous estimation
Extraction, Qualitative and Quantitative Determination of Secondary Metabolites of Bergenia Ciliata (How) Sternb Rhizome
Authors: Kanth Mudassir , Hussain Ahatsham , Shrivastva Pradeep K , Sharma Manik , Tripath Jagrati , Khan Mohammed Azaz 
Published: September 2024

In the last few years, there has been an exponential growth in the field of herbal medicine and gaining popularity both in developing and developed countries because of their natural origin and less side effects. Medicinal plants continue to be an important therapeutic aid for alleviating ailments of humankind. Bergenia ciliata Sternb (B. ciliate, Saxifragaceae) commonly known as Paashaanbhed is a rhizomatic herb with fleshy leaves, growing upto 30 cm tall, having a stout creeping rhizomatous rootstock with scars and intermittent axillary buds. Plant is quite hardy and able to survive frost during winter turning reddish in colour. It is evergreen and flowers in April to June. Its flowers are white-pink and purple in colour. Stem is short and the rhizome comes out from the cervices of rocks and hangs in the air in sloppy areas. Leaves are 5-30 cm long, glabrous, sparsely hairy in margins, broadly obovate or elliptic, finely or sparsely denticulate or shallowly sinuatedenate. It is also reported to cure fevers, diarrhoea, boils ophthalmia and cough. It is also used to dissolve kidney and bladder stones and forms an important ingredient in various kidney curative herbal drugs. The important phytochemicals of this plant include bergenin, gallic acid, (+)-catechin, Paashanolactone, sitoindoside, quercitin, (+) afzelechin etc tannic acid, albumen, mucilage, glucose, wax, metarbin and mineral salts, saponin, flavonoid, glycosides and polysaccharides, xyloglucan, taraxerol, carotenoids, cryptoxanthin. The aim of the present study is to examine B. ciliate rhizomes for phytochemical profile. Phytochemical analysis revealed the presence of phenols, flavonoids, tannins, saponins, alkaloids, fixed oil and fats. The total phenolics content of ethyl acetate and methanolic extract was (208,442mg/100mg), followed by flavonoids (433, 446mg/100mg). The present study concluded that the crude extract of B. ciliate is a rich source of secondary phytoconstituents which impart significant antioxidant potential. This work also contributes significantly to support the claim about the use of this herb in folk medicines.
A review of Tuberculosis (SIL) with special reference to Unani medicine
Authors: Salahuddin , , Anjum Rubi 
Published: September 2024

Tuberculosis (TB) is an airborne infectious disease commonly affects the lungs. TB is a major global health problem which causes ill-health among millions of people each year. The disease is caused by infection via the lung with Mycobacterium tuberculosis, In Unani System of Medicine, tuberculosis is better known by the name of Diq or Sil. Both the terms are considered synonyms. Sil being emaciation and Diq the low grade fever (Humma-e-Diq). Diq develops when the abnormal heat (Hararate ghariba) destroys the normal body fluids (Rutoobat-e-tabayee) of human body resulting in Hot & Dry (Har yabis) vital organs. This paper reviews the concept of tuberculosis, its etiology and management, described by ancient Unani scholars in detail.
Keywords: Tuberculosis, Sil, Diq, Hararate ghariba, Rutoobate tabayee
Anti-inflammatory and Anti-helminthic potential of Methanolic and Aqueous extract of Polygonum alpinum rhizomes
Authors: Mir Prince Ahad , Din Roohi Mohi-u- , Dar Mohd. Akbar , Bader Ghulam Nabi 
Published: September 2024

Aim: The present research work was carried out to evaluate the anti-inflammatory and anthelminthic activity of the extracts of Polygonum alpinum rhizomes. Methods: Fresh rhizomes of the P. alpinum were collected, washed and shade dried. The methanolic and aqueous extracts were first tested for phytochemical screening. In-vitro anti-inflammatory activities of crude extracts were evaluated by HRBC (Human Red Blood Cell) membrane stabilization method and percentage inhibition of protein denaturation method. Similarly anti-helminthic activity was evaluated using earthworms of 6-8 cm in length and 0.3-0.4 cm in width and the results were compared with standard drug Albendazole. Results: Phytochemical analysis of the extract reveals the of presence of Carbohydrates, Cardiac glycosides, Coumarins, proteins, amino acids, flavonoids, saponins, steroids, terpenoids, tannins and phenolics. The methanolic extract showed potent membrane stabilizing and significantly inhibit protein denaturation as compared to standard indomethacin. Methanolic extract at the concentration of 125μg/mL showed 81.29% membrane stabilizing activity as compared to aqueous extract 64.72%. Standard indomethacin showed 95.56 % activity at the same concentration. Similarly, methanolic extract at 500μg/mL showed 72.70% inhibition of protein denaturation as compared to aqueous extract 64.72%. Standard indomethacin showed 88.26% inhibition of protein denaturation at the same concentration. Both the methanolic and aqueous extracts showed dose dependent anthelminthic activity as compared to standard Albendazole. Conclusion: These results suggest that both the extracts from P. alpinum have promising anti-inflammatory and anthelmintic activity and that more broadly; plant extracts are a potential rich source of anti-inflammatory and anthelmintics to combat these diseases.
TÉCNICAS DE RECARBONIZAÇÃO DO SOLO NA AGRICULTURA SUSTENTÁVEL
Authors: Ornelas Neliane Marinho Queiroz , Franco David Gabriel de Barros , Ságio Solange Aparecida , Tonani Flávia Lucila , Silveira Márcio Antônio da 
Published: September 2024

Este estudo apresenta algumas iniciativas direcionadas para a agricultura sustentável, com enfoque na recarbonização do solo, como uma opção para mitigar mudanças climáticas e principalmente reduzir as emissões de gases de efeito estufa (GEE), esses gases são conhecidos por contribuir para o aquecimento global e as mudanças climáticas. Objetiva-se apresentar quatro estudos que trazem uma abordagem direcionada sobre a importância do solo como provedor principal, assim como a sua degradação e a necessidade de um manejo sustentável. O impacto das atividades agrícolas, surge como um ponto de interrogação constante, aliado a necessidade planos que evidenciem a participação da sociedade e do governo com ações direcionadas para aumentar o carbono orgânico que faz parte do ciclo global do carbono, influenciando as concentrações atmosféricas de dióxido de carbono (CO₂), auxiliando como prática restaurativa são pontos cruciais para o desenvolvimento sustentável das cadeias produtivas.
Detection of levamisole and its metabolites in horses after oral levamisole administration over seven days
Authors: Adam Emma , Scollay Mary , Howard Bruce , Taormina John , Hartmann Petra , Knych Heather 
Published: September 2024

Abstract

OBJECTIVE
Levamisole is a regulated substance sometimes administered to racehorses to treat equine protozoal myelitis. Metabolites include compound II, aminorex, and pemoline. Aminorex and pemoline are Horseracing Integrity and Safety Authority–banned substances. Previous studies have examined single doses of the drug. This study examined the disposition of levamisole after 7 days of dosing.

ANIMALS
6 healthy Thoroughbred geldings.

METHODS
Horses were treated with 500 mg (approx 0.91 to 1 mg/kg) of compounded levamisole hydrochloride paste PO every 12 hours for a total of 13 doses over 7 days. Serum and urine samples were analyzed for levamisole and its metabolites over a 28-day period.

RESULTS
The terminal half-life of levamisole in serum was variable between horses. Following the last dose of levamisole on day 7, serum levamisole levels took 3 to 14 days (days 10 to 21) to fall below the limit of detection (LOD) in 5 of 6 horses. Serum from 1 horse remained over LOD on the last testing day (day 28). In urine, following the final dose (day 7), levamisole was below LOD on day 13 (6 days after final dose) and aminorex was below LOD on day 10 (3 days after final dose). Compound II was above LOD in 4 of 5 horses sampled on the last sampling day (day 28).

CLINICAL RELEVANCE
Levamisole and its metabolites can be detected for variable lengths of time in horses, with detection lasting for days to weeks following multiple doses. This study supports the Racing Medication and Testing Consortium Advisory on levamisole, which suggests that clearance sample testing should be conducted on treated horses to verify elimination of levamisole and its metabolites.
HUBUNGAN USIA DINI MELAKUKAN HUBUNGAN SEKSUAL DENGAN TERJADINYA KANKER SERVIKS DI RSUP PROF. DR. I.G.N.G NGOERAH
Authors: Nara Iswari Putu Ristya , Wijaya Surya I Gede Ngurah Harry , Bayu Mahendra I Nyoman , Budiana I Nyoman Gede 
Published: September 2024

Kanker serviks merupakan penyakit ganas yang terjadi di serviks atau leher rahim dan merupakan salah satu kanker menyebabkan kematian terbesar di dunia. Melakukan aktivitas seksual usia dini merupakan salah satu faktor resiko terjadinya infeksi HPV yang nantinya akan berpeluang untuk berkembang menjadi kanker. Tujuan dari penelitian ini adalah untuk mengetahui hubungan melakukan aktivitas seksual usia dini dengan kanker serviks di Rumah Sakit Umum Pusat Prof. Dr. I.G.N.G Ngoerah.
Penelitian yang digunakan adalah studi cross sectional deskriptif retrospektif dengan menggunakan data sekunder data rekam medis pasien kanker serviks. Teknik pengumpulan sampel yang digunakan dalam penelitian ini adalah minimal sampling dengan subjek yang memenuhi seluruh kriteria inklusi minimal sebanyak 43 orang.
Distribusi pasien kanker serviks berdasarkan usia pertama kali berhubungan seksual adalah pengidap kanker serviks yang melakukan hubungan seksual dibawah 20 tahun sebanyak 55% dan penyidap kanker serviks yang melakukan hubungan seksual diatas usia 20 tahun sebanyak 45%. Melalui uji Chi Square didapatkan p value 0,001 (significance value <0,05) sehingga dapat disimpulkan bahwa terdapat hubungan signifikan antara melakukan hubungan seksual dibawah umur 20 tahun dengan terjadinya kanker serviks di RSUP Prof. Dr. I.G.N.G Ngoerah.

Kata Kunci : Kanker Serviks, Hubungan Seksual Usia Dini, Faktor Risiko
SURVIVAL RATE OF CERVICAL CANCER PATIENTS IN PROF. DR. I.G.N.G. NGOERAH GENERAL HOSPITAL
Authors: Mahastya I Wayan Cahya , Budiana I Nyoman Gede , Mulyana Ryan Saktika , Suwardewa Tjokorda Gde Agung , Wijaya Surya I Gede Ngurah Harry 
Published: September 2024

ABSTRACT

Cervical cancer is a type of cancer that develops in the cervix as a result of an infection with high-risk HPV. Cervical cancer patients have varying survival rates. This will be influenced by the patient's prognostic factors such as age, histopathological type, metastases, stage, tumor size, and treatment modalities. This research employs an analytical observational approach and utilizes a retrospective cohort research design. Survival rates will be measured using Kaplan Meier and log-rank based on prognostic factors. The research was carried out at RSUP Prof. Dr. I.G.N.G. Ngoerah, utilizing data from cervical cancer patients in the year 2021. The sample in this study was 245 samples. From 245 samples, 55 patients (22.4%) experienced events (died), 32 patients (13.1%) were uncensored (alive), and 158 patients (64.5%) were censored. The highest one-year survival rate based on prognostic factors was patients with age <40 years (78.8%), histopathological type of SCC (78.1%), no metastases (78.2%), patients with stage I (81%), tumor size < 2 cm (82.9%), and treatment modalities of chemotherapy, radiotherapy, and hysterectomy (90%). The results of the analysis based on the log rank test which reports only the incidence of metastasis factors show significant results on the one-year survival of cervical cancer patients. The overall one-year survival rate for cervical cancer patients is 77.6%. To determine the survival rate for cervical cancer patients over three and five years, further research is required.

Keywords: Cervical cancer, HPV, Kaplan-Meier, Log rank, and Survival rate.