bluuebunny/crossref_metadata_2025_split huggingface dataset:
Membrane Tension Regulation is Required for Wound Repair
Authors: Raj Nikita , Weiß Martin S. , Vos Bart E. , Weischer Sarah , Brinkmann Frauke , Betz Timo , Trappmann Britta , Gerke Volker 
Published: October 2024

AbstractDisruptions of the eukaryotic plasma membrane due to chemical and mechanical challenges are frequent and detrimental and thus need to be repaired to maintain proper cell function and avoid cell death. However, the cellular mechanisms involved in wound resealing and restoration of homeostasis are diverse and contended. Here, it is shown that clathrin‐mediated endocytosis is induced at later stages of plasma membrane wound repair following the actual resealing of the wound. This compensatory endocytosis occurs near the wound, predominantly at sites of previous early endosome exocytosis which is required in the initial stage of membrane resealing, suggesting a spatio‐temporal co‐ordination of exo‐ and endocytosis during wound repair. Using cytoskeletal alterations and modulations of membrane tension and membrane area, membrane tension is identified as a major regulator of the wounding‐associated exo‐ and endocytic events that mediate efficient wound repair. Thus, membrane tension changes are a universal trigger for plasma membrane wound repair modulating the exocytosis of early endosomes required for resealing and subsequent clathrin‐mediated endocytosis acting at later stages to restore cell homeostasis and function.
SEC31a‐ATG9a Interaction Mediates the Recruitment of COPII Vesicles for Autophagosome Formation
Authors: Nie Jiaming , Ma Shaoyang , Wu Linyue , Li Ye , Cao Jiao , Li Meng , Mei Peter , Cooper Paul R. , Li Ang , Pei Dandan 
Published: October 2024

AbstractAutophagy plays an important role in determining stem‐cell differentiation. During the osteogenic differentiation of mesenchymal stem cells (MSCs), autophagosome formation is upregulated but the reason is unknown. A long‐standing quest in the autophagy field is to find the membrane origin of autophagosomes. In this study, cytoplasmic coat protein complex II (COPII) vesicles, endoplasmic reticulum‐derived vesicles responsible for the transport of storage proteins to the Golgi, are demonstrated to be a critical source of osteoblastic autophagosomal membrane. A significant correlation between the number of COPII vesicle and the autophagy level is identified in the rat bone tissues. Disruption of COPII vesicles restrained osteogenesis and decreased the number and size of autophagosomes. SEC31a (an outer coat protein of COPII vesicle) is found to be vital to regulate COPII vesicle‐dependent autophagosome formation via interacting with ATG9a of autophagosomal seed vesicles. The interference of Sec31a inhibited autophagosome formation and osteogenesis in vitro and in vivo. These results identified a novel mechanism of autophagosome formation in osteogenic differentiation of stem cells and identified SEC31a as a critical protein that mediates the interplay between COPII and ATG9a vesicles. These findings broaden the understanding of the regulatory mechanism in the osteogenic differentiation of MSCs.
An AI Agent for Fully Automated Multi‐Omic Analyses
Authors: Zhou Juexiao , Zhang Bin , Li Guowei , Chen Xiuying , Li Haoyang , Xu Xiaopeng , Chen Siyuan , He Wenjia , Xu Chencheng , Liu Liwei , Gao Xin 
Published: October 2024

AbstractWith the fast‐growing and evolving omics data, the demand for streamlined and adaptable tools to handle bioinformatics analysis continues to grow. In response to this need, Automated Bioinformatics Analysis (AutoBA) is introduced, an autonomous AI agent designed explicitly for fully automated multi‐omic analyses based on large language models (LLMs). AutoBA simplifies the analytical process by requiring minimal user input while delivering detailed step‐by‐step plans for various bioinformatics tasks. AutoBA's unique capacity to self‐design analysis processes based on input data variations further underscores its versatility. Compared with online bioinformatic services, AutoBA offers multiple LLM backends, with options for both online and local usage, prioritizing data security and user privacy. In comparison to ChatGPT and open‐source LLMs, an automated code repair (ACR) mechanism in AutoBA is designed to improve its stability in automated end‐to‐end bioinformatics analysis tasks. Moreover, different from the predefined pipeline, AutoBA has adaptability in sync with emerging bioinformatics tools. Overall, AutoBA represents an advanced and convenient tool, offering robustness and adaptability for conventional multi‐omic analyses.
In Situ Reconstructing NiFe Oxalate Toward Overall Water Splitting
Authors: Zhang Zhen , Ren Xiaoyu , Dai Wenyuan , Zhang Hang , Sun Zhengyin , Ye Zhuang , Hou Ying , Liu Peizhi , Xu Bingshe , Qian Lihua , Liao Ting , Zhang Haixia , Guo Junjie , Sun Ziqi 
Published: October 2024

AbstractSurface reconstruction plays an essential role in electrochemical catalysis. The structures, compositions, and functionalities of the real catalytic species and sites generated by reconstruction, however, are yet to be clearly understood, for the metastable or transit state of most reconstructed structures. Herein, a series of NiFe oxalates (NixFe1‐xC2O4, x = 1, 0.9, 0.7, 0.6, 0.5, and 0) are synthesized for overall water splitting electrocatalysis. Whilst NixFe1‐xC2O4 shows great hydrogen evolution reaction (HER) activity, the in situ reconstructed NixFe1‐xOOH exhibits outstanding oxygen evolution reaction (OER) activity. As identified by the in situ Raman spectroscopy and quasi‐in situ X‐ray absorption spectroscopy (XAS) techniques, reconstructions from NixFe1‐xC2O4 into defective NixFe1‐xOOH and finally amorphous NixFe1‐xOOH active species (R‐NixFe1‐xOOH) are confirmed upon cyclic voltammetry processes. Specifically, the fully reconstructed R‐Ni0.6Fe0.4OOH demonstrates the best OER activity (179 mV to reach 10 mA cm−2), originating from its abundant real active sites and optimal d‐band center. Benefiting from the reconstruction, an alkaline electrolyzer composed of a Ni0.6Fe0.4C2O4 cathode and an in situ reconstructed R‐Ni0.6Fe0.4OOH anode achieves a superb overall water splitting performance (1.52 V@10 mA cm−2). This work provides an in‐depth structure‐property relationship understanding on the reconstruction of catalysts and offers a new pathway to designing novel catalyst.
Solvation Modification and Interfacial Chemistry Regulation Via Amphoteric Amino Acids for Long‐Cycle Zinc Batteries
Authors: Wang Hengwei , Wang Keliang , Liang Bin , Wei Manhui , Xiong Jianyin , Zhong Daiyuan , Pei Pucheng 
Published: October 2024

AbstractTo address the issues of dendrite growth and zinc corrosion in rechargeable zinc‐air batteries, multifunctional glycine/valine additives are introduced into the electrolyte. By regulating the solvation shell structure and enhancing interfacial stability, these additives aim to protect the reversibility and stability of the zinc anode. Glycine/valine molecules inhibit the formation of the [Zn(H2O)6]2+ and Zn5(OH)8(OAc)2·2H2O by‐products at the interface by replacing active water molecules in a strong alkaline environment. Additionally, they form a hydrophobic electric double layer on the zinc metal surface, during the charge/discharge process, and construct an in situ solid electrolyte interface layer. This further suppresses the hydrogen evolution reaction and dendrite growth. The superior long‐term cycling stability of Zn||Zn cells, Zn||Cu, and zinc‐air full cells demonstrates the effectiveness of glycine/valine additives.
Ring‐Opening Polymerization Reconfigures Polyacrylonitrile Network for Ultra Stable Solid‐State Lithium Metal Batteries
Authors: Liu Han , Liao Yaqi , Leung Chihon , Zhang Yangqian , Yang Yuewen , Liu Fangyan , Wei Ying , Fan Che , Zhang Shuoxiao , Wang Donghai , Yan Jie , Liu Qi , Chung Chiyuen , Ren Yang , Huang Yunhui , Yang Jiayi 
Published: October 2024

AbstractPolyacrylonitrile (PAN) is a promising polymer for solid‐state lithium (Li) metal batteries (SSLMBs). However, the low ionic conductivity of PAN‐based solid polymer electrolytes (SPEs) and unstable Li/PAN interface hinder the applications of PAN in SSLMBs. Herein, a strategy of ring‐opening polymerization is proposed to reconfigure the PAN‐based SPE network. Triggered by the alkaline species from Li6.4La3Zr1.4Ta0.6O12 nanoparticles, ethylene carbonate (EC) undergoes nucleophilic ring‐opening reaction, and subsequently forms dipole–dipole interaction with the PAN chain. This polymerization process consequently reconfigures PAN segment, endowing the SPE with rapid Li+ transport channels and enhanced interfacial stability with Li metal. As a result, the designed PAN‐based SPE demonstrates high ionic conductivity of 2.96 × 10−4 S cm−1 and Li+ transference number of 0.56 at 25 °C. The Li/Li symmetric cells with the reconfigured PAN network deliver a high critical current density of 1.8 mA cm−2 and maintain stable Li plating/stripping for 1200 h. A high‐capacity retention of 90.1% after 1000 cycles at 2 C is achieved in LiFePO4 (LFP)/Li solid‐state cells with PAN‐based SPEs. Moreover, the LFP/Li and LiNi0.8Co0.1Co0.1O2/Graphite pouch batteries both present good cycling and safety performances. This strategy provides new insights into designing high‐performance PAN‐based SPE for SSLMBs.
A Rechargeable Zn–Air Battery with High Energy Efficiency Enabled by a Hydrogen Peroxide Bifunctional Catalyst
Authors: Kottaichamy Alagar Raja , Tzadikov Jonathan , Pedersen Angus , Barrio Jesús , Mark Gabriel , Liberman Itamar , Upcher Alexander , Volokh Michael , Hod Idan , Barzilai Shmuel , Noked Malachi , Shalom Menny 
Published: October 2024

AbstractRechargeable alkaline zinc–air batteries (ZAB) hold great promise as a viable, sustainable, and safe alternative energy storage system to the lithium‐ion battery. However, the practical realization of ZABs is limited by their intrinsically low energy trip efficiency, stemming from a large charge and discharge potential gap. This overpotential is attributed to the four‐electron oxygen evolution and reduction reactions and their sluggish kinetics. Here, a new concept based on two‐electron generation and consumption of hydrogen peroxide at the air electrode is introduced. The O2/peroxide chemistry, facilitated by a newly developed Ni‐based bifunctional electrocatalyst, enables fast peroxide generation/consumption, exceptional energy efficiency, high durability, and high capacity. Hence, this new design offers substantial progress toward the commercialization of high energy density metal–air batteries.
Metal‐coordinated amino acid/peptide/protein‐based supramolecular self‐assembled nanomaterials for anticancer applications
Authors: Shabbir Maryam , Atiq Atia , Wang Jiahua , Atiq Maria , Saeed Nyla , Yildiz Ibrahim , Yan Xuehai , Xing Ruirui , Abbas Manzar 
Published: October 2024

AbstractBiomolecules with metals can form supramolecular nanomaterials through coordination assembly, opening new avenues for cancer theranostics and bringing unique insights into personalized nanomedicine. These biomaterials have been considered versatile and innovative nanoagents due to their structure‒function control, biological nature, and simple preparation methods. This review article summarized the recent developments in multicomponent nanomaterials formed from metal coordination interactions with amino acids, peptides, and proteins, together with anticancer drugs, for cancer theranostics. We discussed the role of functional groups anchored in building blocks for coordination interactions, and subsequently, the types of interactions were examined from a structure‒function perspective. Amino acids with different metals and anticancer drugs forming supramolecular nanomaterials and their anticancer mechanisms were highlighted. Peptides with different metals and anticancer drugs, proteins with metals and anticancer drugs used for material formations, and anticancer activity have been discussed. Ultimately, the conclusion and future outlook for multicomponent supramolecular nanomaterials offer fundamental insights into fabrication design and precision medicine.
Temporal lobe evolution in Hominidae and the origin of human lobe proportions
Authors: Pearson Alannah , Polly P. David 
Published: October 2024

AbstractObjectives Evolutionary changes in hominin social complexity have been associated with increases in absolute brain size. The temporal lobes are nestled in the middle cranial fossae (MCF) of the skull, the dimensions of which allow estimation of temporal lobe volume (TLV) in extant and fossil taxa. Materials and Methods The main aim of this study is to determine where along the hominid phylogeny, major temporal lobe size transitions occurred. We used computed tomography (CT) scans of crania, 3D photogrammetry data, and laser surface scans of endocranial casts to measure seven MCF metrics in 11 extant anthropoid taxa using multiple regressions to estimate TLV in 5 extant hominids and 10 fossil hominins. Phylogenetic comparative methods mapped temporal lobe size, brain size, and temporal lobe proportions onto phylogenetic trees broadly for Hominidae and specifically for Hominini. Results Extant Homo sapiens were not an outlier in relative brain size, temporal lobe size, or proportions of the temporal lobes, but some proportions within the lobe were uniquely altered. The most notable changes in relative temporal lobe size and proportions saw a decrease in relative temporal lobe size and proportions in the genus Pan compared to other extant great apes and fossil hominins while there was a relative increase in the temporal lobe width and length in Australopithecus–Paranthropus clade compared to the genus Homo and other extant great apes including modern humans. Discussion We do not find support for the social brain, environmental or functional craniology hypotheses alone but think it prudent to consider the implications of cerebral reorganization between the temporal lobes and other regions of the brain within the context of these hypotheses and with future investigation is warranted.
Anisotropic Spheres with Tolman–Kuchowicz Spacetime in the Context of f(Q,T)$f(Q,T)$ Gravity
Authors: Chalavadi Chaitra Chooda , Venkatesha V. , Kumara H Aruna 
Published: October 2024

AbstractThis study primarily focuses on exploring the nature of anisotropic spheres within the framework of extended symmetric teleparallel gravity. To accomplish this, an anisotropic matter distribution for gravity model with Tolman–Kuchowicz spacetime is considered. Through this analysis, the necessary conditions for matching the interior and exterior geometries of the spheres are discussed and calculated the values of the unknown parameters involved. Furthermore, the physical properties of these spheres are analyzed using observational data from compact objects. The results demonstrate that the interior solutions obtained for anisotropic spheres fulfill all requisite physical criteria, thereby ensuring the stability of our model.
Anaesthetic management of a patient with idiopathic pulmonary arterial hypertension, suprasystemic pulmonary artery pressures and carcinoma of the ascending colon*
Authors: Gurajala I. , Reddy G. P. , Vejendla K. , Vanaja V. , Verma G. S. R. , Jonnavithula N. 
Published: October 2024

SummaryA 35‐year‐old woman with severe pulmonary arterial hypertension underwent open hemicolectomy with cholecystectomy under combined general and epidural anaesthesia. Intra‐operative pulmonary artery pressure, as measured by Swan‐Ganz catheter, was suprasystemic and managed with inodilators. She developed postoperative right ventricular dysfunction requiring inotropes, incremental pulmonary vasodilators and prolonged oxygen supplementation. One year after surgery, she is recurrence‐free with oxygen saturations of 88–90% on air. This case highlights that with meticulous care and multidisciplinary team input, patients with severe pulmonary arterial hypertension can have favourable outcomes after major cancer surgery.
Stress resistance, antiaging, and neuroprotective activities of baicalein 5,6‐dimethyl ether and Alnus rugosa extract in Caenorhabditis elegans model
Authors: Ayoub Iriny M. , Eldahshan Omayma A. , Roxo Mariana , Zhang Shaoxiong , Wink Michael , Singab Abdel Nasser B. 
Published: October 2024

AbstractThe leaf extract of Alnus rugosa (AR) together with the isolated compound baicalein 5,6‐dimethyl ether (BME) were investigated for their antioxidant, radical scavenging, antiaging, and neuroprotective properties using the Caenorhabditis elegans model. The stress resistance and antiaging potential of AR and BME were assessed in wild‐type N2 and transgenic C. elegans strains CF1553, TJ356, and BA17. Transgenic CL4176 expressing the human amyloid‐beta peptide (Aβ) was used as a model for Aβ toxicity, whereas transgenic AM141 expressing polyQ aggregates was employed as a model for Huntington's disease. An in silico molecular docking study using Discovery Studio 4.5 was performed to elucidate the putative binding mode of BME to the active sites of Daf‐2 protein, involved in longevity and oxidative stress resistance in C. elegans. BME and AR significantly delayed the appearance of oxidative stress markers in wild‐type N2 and transgenic strains TJ356 and CF1553, affecting the DAF‐16/FOXO transcription factor subcellular distribution and inducing expression of the sod‐3 antioxidative gene. Pretreatment with AR significantly reduced the aging marker lipofuscin accumulation in BA17 worms, its effect was greater than that of epigallocatechin gallate, suggesting a potential antiaging effect. Neuroprotective effects of AR and BME were confirmed in AM141 transgenic worms, inducing a significant reduction in the score of polyQ40::GFP aggregates. Moreover, BME (25 µg/mL) resulted in a significant delay in Aβ‐induced paralysis in CL4176 worms. In silico molecular modeling revealed that BME exhibited good fitting scores within the active sites of the Daf‐2 protein. AR and BME exert beneficial effects in the modulation of age‐related markers and attenuation of neurotoxicity in neurodegenerative disorders. Hence, AR and BME could be recognized as promising antioxidant and neuroprotective natural drug candidates that could be included in neuro‐nutraceuticals.
Negative consequences of information gatekeeping through algorithmic technologies: An Annual Review of Information Science and Technology (ARIST) paper
Authors: Potnis Devendra , Tahamtan Iman , McDonald Luke 
Published: October 2024

AbstractRarely any study investigates how information gatekeeping through the solutions and services enabled by algorithms, hereafter referred to as algorithmic technologies (AT), creates negative consequences for the users. To fill this gap, this state‐of‐the‐art review analyzes 229 relevant articles from diverse academic disciplines. We employed thematic analysis to identify, analyze, classify, and reveal the chain reactions among the negative consequences. We found that the gatekeeping of information (text, audio, video, and graphics) through AT like artificial intelligence (e.g., chatbots, large language models, machine learning, robots), decision support systems (used by banks, grocery stores, police, etc.), hashtags, online gaming platforms, search technologies (e.g., voice assistants, ChatGPT), and Web 3.0 (e.g., Internet of Things, non‐fungible tokens) creates or reinforces cognitive vulnerability, economic divide and financial vulnerability, information divide, physical vulnerability, psychological vulnerability, and social divide virtually and in the offline world. Theoretical implications include the hierarchical depiction of the chain reactions among the primary, secondary, and tertiary divides and vulnerabilities. To mitigate these negative consequences, we call for concerted efforts using top‐down strategies for governments, organizations, and technology experts to attain more transparency, accountability, ethical behavior, and moral practices, and bottom‐up strategies for users to be more alert, discerning, critical, and proactive.
Chromofungin mitigates free fatty acids‐induced endothelial inflammation via inhibition of NOD‐like receptor thermal protein domain‐associated protein 3 mediated by adenosine 5ʹ‐monophosphate‐activated protein kinase
Authors: Lan Qing , Chen Jian , Yang Yongqiang 
Published: October 2024

AbstractFree fatty acids (FFAs) have emerged as significant risk factors for atherosclerosis (AS). Prolonged exposure to FFAs induces vascular endothelial injury, including inflammatory responses and oxidative stress, which are central events in AS. Chromofungin (CHR), a peptide derived from chromogranin A (CGA), has been implicated in various biological functions. However, its physiological roles in endothelial biology and its involvement in the pathological development of AS have not been previously reported. In the present study, we investigated the underlying mechanisms through which CHR exerts its beneficial effects on FFA‐challenged human aortic endothelial cells (HAECs). We found that treatment with CHR ameliorated the FFA‐induced reduction in cell viability and increase in lactate dehydrogenase (LDH) release. Additionally, CHR mitigated oxidative stress by reducing mitochondrial reactive oxygen species (ROS) levels and increasing superoxide dismutase (SOD) activity. Furthermore, exposure to FFAs increased NADPH oxidase (NOX) 4 expression at both the mRNA and protein levels, which were attenuated by CHR in a dose‐dependent manner. Notably, CHR reduced the levels of nucleotide‐binding domain and leucine‐rich repeat‐containing (NLR) family pyrin domain containing 3 (NLRP3), apoptosis‐associated speck‐like protein containing a CARD (ASC), and cleaved caspase‐1 (p10), key components of the NLRP3 inflammasome complex, as well as interleukin 1β (IL‐1β) and interleukin‐18 (IL‐18) expression. Mechanistically, it was demonstrated that FFAs reduced the phosphorylation of AMP‐activated protein kinase (AMPK) and acetyl‐CoA carboxylase (ACC), which were rescued by CHR in a dose‐dependent manner. Conversely, inhibition of AMPK with its specific inhibitor compound C abolished the protective effects of CHR against FFA‐induced activation of the NLRP3 inflammasome in HAECs. Based on these findings, we conclude that CHR may serve as a promising agent for maintaining normal endothelial cell function and treating AS.
Highly Sensitive Detection of Sulfur Ion in Water by Four‐Color Fluorescence Based on Cu‐Containing Metal–Organic Framework
Authors: Wang Chen , Li Wenheng , Wang Xiaohong , Xiang Dongshan , Zhai Kun 
Published: October 2024

ABSTRACTIn this paper, a highly sensitive method for sulfur ion (S2−) detection was developed based on a four‐color fluorescence probe constructed from copper‐containing metal–organic framework (CuBDC) and four dye‐labeled single‐strand DNA (ssDNA). In the absence of S2−, dye‐labeled ssDNA can be adsorbed on the surface of CuBDC, and the dyes are close to copper ion on the CuBDC surface, their fluorescence is quenched by copper ion, and their fluorescence signals are weak. In the presence of S2− in the system, S2− reacts with copper ion in CuBDC to form CuS, which has a more stable structure than complex CuBDC, resulting in the decomposition of CuBDC. In this case, dye‐labeled ssDNA are detached from the CuBDC surface and dissolved in the solution, and the fluorescence of the dyes is restored. Under the optimized conditions, there is a good linear relationship between the total fluorescence intensity of four dyes and the concentration of S2− in the range of 2 × 10−9 to 5 × 10−8 mol/L; the detection limit is 2.2 × 10−10 mol/L. The method has a good selectivity and accuracy, and it can be applied to the analysis and detection of S2− in actual water samples.