bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of T‐type calcium channel isoforms to cold and mechanical sensitivity in naïve and oxaliplatin‐treated mice of both sexes
Authors: Antunes Flavia T. T. , Gandini Maria A. , Gadotti Vinicius M. , Quintão Nara Lins Meira , Santin José Roberto , Souza Ivana A. , David Laurence S. , Snutch Terrance P. , Hildebrand Michael , Zamponi Gerald W. 
Published: September 2024

Background and PurposeThe chemotherapy agent oxaliplatin can give rise to oxaliplatin‐induced peripheral neuropathy (OIPN). Here, we investigated whether T‐type calcium channels (Cav3) contribute to OIPN.Experimental ApproachWe chronically treated mice with oxaliplatin and assessed pain responses and changes in expression of Cav3.2 calcium channels. We also tested the effects of T‐type channel blockers on cold sensitivity in wild‐type and Cav3.2 null mice.Key ResultsOxaliplatin treatment led to mechanical and cold hypersensitivity in male and female mice. Mechanical hypersensitivity persisted in Cav3.2 null mice of both sexes. Intraperitoneal or intrathecal delivery of pan T‐type channel inhibitors attenuated mechanical hypersensitivity in wild‐type but not Cav3.2 null mice. Remarkably cold hypersensitivity occurred in female but not male Cav3.2 null mice even without oxaliplatin treatment. Unexpectedly, intrathecal, intraplantar or intraperitoneal delivery of T‐type channel inhibitors Z944 or TTA‐P2 transiently induced cold hypersensitivity in both male and female wild‐type mice. Acute knockdown of specific Cav3 isoforms revealed that the depletion of Cav3.1 in males and depletion of either Cav3.1 or Cav3.2 in females triggered cold hypersensitivity. Finally, reducing Cav3.2 expression by disrupting the interactions between Cav3.2 and the deubiquitinase USP5 with the small organic molecule II‐2 reversed oxaliplatin‐induced mechanical and cold hypersensitivity and importantly did not trigger cold allodynia.Conclusion and ImplicationsAltogether, our data indicate that T‐type channels differentially contribute to the regulation of cold and mechanical hypersensitivity, and raise the possibility that T‐type channel blockers could promote cold allodynia.
AMP‐activated protein kinase in the amygdala and hippocampus contributes to enhanced fear memory in diabetic mice
Authors: Yamagishi Aimi , Yonemochi Naomi , Kimura Ai , Takenoya Fumiko , Shioda Seiji , Waddington John L. , Ikeda Hiroko 
Published: September 2024

AbstractBackground and PurposeDiabetic patients have an increased risk of psychiatric disorders. Because hyperglycaemia increases L‐lactate in the brain and L‐lactate inhibits AMP‐activated protein kinase (AMPK), this study investigated the role of L‐lactate and AMPK in strengthened fear memory, a model for human psychiatric disorders, in diabetic mice.Experimental ApproachThe diabetic model was mice injected with streptozotocin. Fear memory was measured using the conditioned fear test with low (0.45 mA) or high (0.50 mA) foot shock to cause low and high freezing, respectively. Protein levels of AMPK and phosphorylated AMPK (pAMPK) were measured by western blotting and immunohistochemistry.Key ResultsAt 0.45 mA, the AMPK inhibitor dorsomorphin increased freezing, which was inhibited by the AMPK activator acadesine. In contrast, at 0.50 mA, acadesine decreased freezing, which was inhibited by dorsomorphin. In diabetic mice, pAMPK was decreased in the amygdala and hippocampus. Diabetic mice showed increased freezing at 0.45 mA, which was inhibited by acadesine. In the amygdala and hippocampus, L‐lactate was increased in diabetic mice and injection of L‐lactate into non‐diabetic mice increased freezing at 0.45 mA. In addition, L‐lactate decreased pAMPK in the hippocampus, but not the amygdala, and increase in freezing induced by L‐lactate was inhibited by acadesine. Dorsomorphin‐induced increase in freezing was inhibited by the AMPA receptor antagonist NBQX.Conclusions and InterpretationIn diabetic mice, L‐lactate is increased in the amygdala and hippocampus, possibly through hyperglycaemia, which strengthens fear memory through inhibition of AMPK and activation of glutamatergic function.
Glycaemic and weight effects of metabolic surgery or semaglutide in diabetes dosage for patients with type 2 diabetes
Authors: Stenberg Erik , Cao Yang , Ottosson Johan , Hedberg Suzanne , Näslund Erik 
Published: September 2024

AbstractAimTo compare weight and glucometabolic outcomes of semaglutide and metabolic and bariatric surgery (MBS) for patients with type 2 diabetes and obesity.Materials and MethodsPatients treated with either semaglutide for a duration of ≥2 years or MBS in Sweden were identified within the Scandinavian Obesity Surgery Registry and the National Diabetes Registry and matched in a 1:1–2 ratio using a propensity score matching with a generalized linear model, including age, sex, glycated haemoglobin before treatment, duration of type 2 diabetes, use of insulin, presence of comorbidities and history of cancer, with good matching results but with a remaining imbalance for glomerular filtration rate and body mass index, which were then adjusted for in the following analyses. Main outcomes were weight loss and glycaemic control.ResultsThe study included 606 patients in the surgical group matched to 997 controls who started their treatment from 2018 until 2020. Both groups improved in weight and glucometabolic control. At 2 years after the intervention, mean glycated haemoglobin was 42.3 ± 11.18 after MBS compared with 50.7 ± 12.48 after semaglutide treatment (p < 0.001) with 382 patients (63.0%) and 139 (13.9%), respectively, reaching complete remission without other treatment than the intervention (p < 0.001). Mean total weight loss reached 26.4% ± 8.83% after MBS compared with 5.2% ± 7.87% after semaglutide (p < 0.001).ConclusionSemaglutide and MBS were both associated with improvements in weight and improved glycaemic control at 2 years after the start of the intervention, but MBS was associated with better weight loss and glucometabolic control.
Genetic Sex and Origin Identification Suggests Differential Migration of Male and Female Atlantic Bluefin Tuna (Thunnus thynnus) in the Northeast Atlantic
Authors: Nielsen Einar Eg , Birnie‐Gauvin Kim , Baktoft Henrik , Arrizabalaga Haritz , Brodin Tomas , Cardinale Massimiliano , Casini Michele , Helström Gustav , Jansen Teunis , Koed Anders , Lundberg Petter , MacKenzie Brian R. , Medina Antonio , Post Søren , Rodriguez‐Ezpeleta Naiara , Sundelöf Andreas , Varela José Luis , Aarestrup Kim 
Published: September 2024

ABSTRACTKnowledge about sex‐specific difference in life‐history traits—like growth, mortality, or behavior—is of key importance for management and conservation as these parameters are essential for predictive modeling of population sustainability. We applied a newly developed molecular sex identification method, in combination with a SNP (single nucleotide polymorphism) panel for inferring the population of origin, for more than 300 large Atlantic bluefin tuna (ABFT) collected over several years from newly reclaimed feeding grounds in the Northeast Atlantic. The vast majority (95%) of individuals were genetically assigned to the eastern Atlantic population, which migrates between spawning grounds in the Mediterranean and feeding grounds in the Northeast Atlantic. We found a consistent pattern of a male bias among the eastern Atlantic individuals, with a 4‐year mean of 63% males (59%–65%). Males were most prominent within the smallest (< 230 cm) and largest (> 250 cm) length classes, while the sex ratio was close to 1:1 for intermediate sizes (230–250 cm). The results from this new, widely applicable, and noninvasive approach suggests differential occupancy or migration timing of ABFT males and females, which cannot be explained alone by sex‐specific differences in growth. Our findings are corroborated by previous traditional studies of sex ratios in dead ABFT from the Atlantic, the Mediterranean, and the Gulf of Mexico. In concert with observed differences in growth and mortality rates between the sexes, these findings should be recognized in order to sustainably manage the resource, maintain productivity, and conserve diversity within the species.
Decoding machine learning in nursing research: A scoping review of effective algorithms
Authors: Choi Jeeyae , Lee Hanjoo , Kim‐Godwin Yeounsoo 
Published: September 2024

AbstractIntroductionThe rapid evolution of artificial intelligence (AI) technology has revolutionized healthcare, particularly through the integration of AI into health information systems. This transformation has significantly impacted the roles of nurses and nurse practitioners, prompting extensive research to assess the effectiveness of AI‐integrated systems. This scoping review focuses on machine learning (ML) used in nursing, specifically investigating ML algorithms, model evaluation methods, areas of focus related to nursing, and the most effective ML algorithms.DesignThe scoping review followed the Preferred Reporting Items for Systematic Review and Meta‐Analysis Extension for Scoping Reviews (PRISMA‐ScR) guidelines.MethodsA structured search was performed across seven databases according to PRISMA‐ScR: PubMed, EMBASE, CINAHL, Web of Science, OVID, PsycINFO, and ProQuest. The quality of the final reviewed studies was assessed using the Medical Education Research Study Quality Instrument (MERSQI).ResultsTwenty‐six articles published between 2019 and 2023 met the inclusion and exclusion criteria, and 46% of studies were conducted in the US. The average MERSQI score was 12.2, indicative of moderate‐ to high‐quality studies. The most used ML algorithm was Random Forest. The four second‐most used were logistic regression, least absolute shrinkage and selection operator, decision tree, and support vector machine. Most ML models were evaluated by calculating sensitivity (recall)/specificity, accuracy, receiver operating characteristic (ROC), area under the ROC (AUROC), and positive/negative prediction value (precision). Half of the studies focused on nursing staff or students and hospital readmission or emergency department visits. Only 11 articles reported the most effective ML algorithm(s).ConclusionThe scoping review provides insights into the current status of ML research in nursing and recognition of its significance in nursing research, confirming the benefits of ML in healthcare. Recommendations include incorporating experimental designs in research studies to optimize the use of ML models across various nursing domains.Clinical RelevanceThe scoping review demonstrates substantial clinical relevance of ML applications for nurses, nurse practitioners, administrators, and researchers. The integration of ML into healthcare systems and its impact on nursing practices have important implications for patient care, resource management, and the evolution of nursing research.
Fusarium Species Causing Dry Rot of Carrot in Central Argentina
Authors: Favaro María Alejandra , Maumary Roxana Lorena , Lutz Alejandra , Soressi Marcelo Carlos , Del Valle Eleodoro , Fernandez Laura Noemí 
Published: September 2024

ABSTRACTCarrot (Daucus carota L. subsp. sativus) cultivation is important in Argentina, with the Garay department in Santa Fe province being a key production area. In recent years, dry rot symptoms have afflicted various carrot cultivars, resulting in substantial field losses and postharvest discards. Several soilborne pathogens, including Fusarium species, have been implicated in similar carrot diseases globally. This study aimed to identify the specific causal agent responsible for dry rot in carrots in central Argentina to enable targeted disease management strategies. Samples of symptomatic carrots were collected from fields in the Garay department. Fungal isolates were obtained from the infected tissue and subjected to morphological and molecular analyses. Pathogenicity tests were conducted to confirm the ability of the isolates to cause disease symptoms in carrots. Based on morphological and molecular identification, isolates were identified as Fusarium nirenbergiae, Fusarium triseptatum and Fusarium solani. Pathogenicity tests demonstrated that the three Fusarium species were capable of causing dry rot symptoms in carrots. This study represents the first report of Fusarium nirenbergiae, Fusarium triseptatum and Fusarium solani causing dry rot in carrots in Argentina.
Effects of Dietary Intake of Marine Ingredients on the Circulating Total Cholesterol Concentration in Domestic Dogs: A Systematic Review and Meta‐Analysis
Authors: Helland Olivia Bysheim , Andreassen Linnea Vikane , Fischer Anne Sofie , Gudbrandsen Oddrun Anita 
Published: September 2024

ABSTRACTA high circulating total cholesterol (TC) concentration increases the risk for atherosclerosis in the domestic dog. Intake of marine foods is associated with a lowering effect on circulating TC concentration in humans and rodents, but the reported effects of marine ingredients on the TC concentration in domestic dogs has not yet been reviewed. The main aim was to investigate the effects of consuming marine ingredients on the TC concentration in domestic dogs. A systematic literature search was performed using the databases PubMed, Web of Science and Embase, structured around the population (domestic dogs), intervention (source and type of marine ingredients, dose, duration), comparator (control diet) and the primary outcome (circulating TC). Articles were assessed for risk of bias using the SYRCLE's tool. A meta‐analysis was conducted in Review Manager v. 5.4.1 (the Cochrane Collaboration), comprising 12 articles with 243 dogs. Consumption of marine oils resulted in a significantly lower circulating TC concentration relative to comparator groups (mean difference −0.70 mmol/L, 95% CI (−1.21, −0.18), p = 0.008), with high statistical heterogeneity (I2 = 78%). The risk of bias is unclear since few of the entries in the SYRCLE's tool were addressed. We did not identify any studies using marine proteins or marine organisms other that fish. To conclude, intake of marine oils results in a lower TC concentration in dogs, thus reducing an important risk factor for atherosclerosis in canines. This study was registered at www.crd.york.ac.uk/PROSPERO/ as CRD42023396943.
Activity pattern of Tityus serrulatus (Scorpiones: Buthidae) in an urban area in the state of São Paulo, Brazil
Authors: Brites‐Neto José , Willmer Julian Nicholas Garcia , Delciellos Ana Cláudia 
Published: September 2024

AbstractTityus serrulatus Lutz & Mello (Scorpiones: Buthidae) is a scorpion endemic to Brazil adapted to synanthropic life, colonising and proliferating in the most populous urban areas in the country. Here, we evaluated its activity pattern in an urban cemetery in the municipality of Americana, state of São Paulo, Brazil. Additionally, we tested the effects of species reproduction and climatic seasons on the activity pattern. The Saudade Municipal Cemetery was sampled between 17:00 and 22:00 h during 455 nights from April 2006 to December 2013. The circular mean and the peak of activity were quantified for the total number of specimens, and for specimens with and without broods. Activity patterns were inferred using a rosette diagram. Circular analysis of variance was used to investigate if activity patterns changed across climatic seasons (wet and dry seasons). A total of 25,969 records (467 specimens with broods) were obtained in the field. The circular mean varied between 19:44 and 19:48 h, and the peak of activity occurred between 18:00 and 20:00 h for all groups. Peaks of activity differed from that recorded under laboratory conditions (between 21:00 and 23:00 h). Activity patterns did not differ for specimens with broods, suggesting that the reproductive condition does not alter the species activity pattern. The activity pattern differed between wet and dry seasons for all specimens and specimens without broods, but differences were small and probably biologically irrelevant, probably because the species tolerates a wide variation in abiotic conditions. Deepening the knowledge of the behaviour activity of T. serrulatus can have practical applications for health surveillance agencies, aiming to increase the effectiveness of scorpion control in urban areas.
Strategic public value(s) governance: A systematic literature review and framework for analysis
Authors: Thabit Sara , Sancino Alessandro , Mora Luca 
Published: September 2024

AbstractThis article offers evidence‐based understanding of public value creation in multi‐actor collaborations by presenting the results of a systematic literature review of empirical studies published within the public administration field. Specifically, it focuses on two primary research questions: How do multi‐actor collaborations generate public value(s)? What types of public value(s) are created by these collaborative endeavors? Our results shed light on 12 strategic governance components for enacting public value(s) governance (PVsG) in multi‐actor collaborations, including six key public values to be considered for discerning and assessing processes of public value generation. We contribute to theory and practice by providing a unifying framework to PVsG which updates the public value strategic triangle combining Moore's managerial action‐focused approach with Bozeman's policy or societally oriented public values approach.
Hamstring Muscle‐Tendon Geometric Adaptations to Resistance Training Using the Hip Extension and Nordic Hamstring Exercises
Authors: Lazarczuk Stephanie L. , Collings Tyler J. , Hams Andrea H. , Timmins Ryan G. , Shield Anthony J. , Barrett Rod S. , Bourne Matthew N. 
Published: September 2024

ABSTRACTTargeted resistance training stimulates hamstring muscle hypertrophy, but its effect on tendon‐aponeurosis geometry is unknown. This study examined changes in hamstring muscle, free tendon, and aponeurosis geometry following a 10 week Nordic or hip extension exercise intervention. Thirty recreationally active males were randomly allocated (n = 10 per group) to a Nordic, hip extension, or control group. Magnetic resonance imaging of both thighs was acquired pre‐ and post‐intervention. Changes in free tendon and aponeurosis volume for each hamstring muscle, biceps femoris long head (BFlh) aponeurosis interface area and muscle volume‐to‐interface area ratio were compared between groups. Regional changes in muscle CSA were examined via statistical parametric mapping. The change in semimembranosus free tendon volume was greater for the Nordic than control group (mean difference = 0.06 cm3, 95% CI = 0.02–0.11 cm3). No significant between‐group differences existed for other hamstring free tendons or aponeuroses. There were no between‐group differences in change in BFlh interface area. Change in BFlh muscle volume‐to‐interface area ratio was greater in the hip extension than Nordic (mean difference = 0.10, 95% CI = 0.007–0.19, p = 0.03) and control (mean difference = 0.12, 95% CI = 0.03–0.22, p = 0.009) groups. Change in muscle CSA following training was greatest in the mid‐portion of semitendinosus for both intervention groups, and the mid‐portion of BFlh for the hip extension group. There was limited evidence for tendon‐aponeurosis hypertrophy after 10 weeks of training with the Nordic or hip extension exercises. For the BFlh, neither intervention altered the interface area although hip extension training stimulated an increase in the muscle volume‐to‐interface area ratio, which may have implications for localized tissue strains. Alternative muscle‐tendon loading strategies appear necessary to stimulate hamstring tendon adaptations.
When market leads innovation: The interplay of internationalisation, innovation and productivity among Swedish wood manufacturing SMEs
Authors: Hosseini Mojtaba , Brege Staffan , Nord Tomas 
Published: September 2024

AbstractWe examine the effects of innovation, productivity and export on small and medium‐sized enterprises (SMEs) in the Swedish wood manufacturing sector. Previous studies have produced mixed results on these topics, which may be due to methodological limitations, contextual differences and inadequate operationalisation of key variables. To address these gaps, we adopt a more specific and rigorous approach, focusing on product innovation and using sophisticated statistical methods to account for endogeneity and other confounding factors. We use a longitudinal dataset to analyse how SMEs select into export markets and learn from exporting, as well as how other factors influence their export performance. We find that innovation and export have a nonlinear relationship, which depends on the level of interaction between SMEs and their international customers, and the degree of fit between their innovative products and the export market. In particular, when SMEs have high international customer engagement, they are more likely to innovate in ways that enhance their export potential. Regarding productivity, we find that self‐selection is more advantageous for SMEs, while learning‐by‐exporting is more consistent in controlling for unobserved factors.
Time‐periodic solutions to heated ferrofluid flow models
Authors: Hamdache Kamel , Hamroun Djamila , Jaffal‐Mourtada Basma 
Published: September 2024

AbstractIn this work, we prove the existence of time‐periodic solutions to a model describing a ferrofluid flow heated from below. Navier–Stokes equations satisfied by the fluid velocity are coupled to the temperature equation and the magnetostatic equation satisfied by the magnetic potential. The magnetization is assumed to be parallel to the magnetic field and is given by a nonlinear magnetization law generalizing the Langevin law. The proof is based on a semi‐Galerkin approximation and regularization methods together with the fixed point method.