bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vernachlässigte klinische Merkmale der follikulotropen Mycosis fungoides: eine große klinische Fallserie
Authors: Baykal Can , Atci Tugba , Ozturk Sari Sule , Polat Ekinci Algun , Buyukbabani Nesimi 
Published: March 2017

ZusammenfassungHintergrund und ZielAls seltene Form der Mycosis fungoides (MF), ist die follikulotrope MF (FMF) durch ein breites Spektrum klinischer Symptome gekennzeichnet. Dazu gehören, neben den vorherrschenden follikulären Läsionen, auch viele atypische Manifestationen. Das Ziel der vorliegenden Studie war eine klinische Bewertung von FMF‐Patienten, unter besonderer Berücksichtigung von vernachlässigten dermatologischen Merkmalen.Patienten und MethodikInsgesamt wurden 27 FMF‐Patienten aus dem 572 Patienten umfassenden MF‐Register unserer Abteilung retrospektiv bezüglich ihrer Demographie sowie der klinischen Merkmale, Behandlungsformen, Nachsorge und Therapieergebnisse bewertet.ErgebnisseNeben den bekannten klinischen Symptomen der FMF fanden wir Lichen‐spinulosus‐artige Läsionen mit begleitender Hypopigmentierung (n = 3) und Alopezie (n = 2), infiltrierte/erhabene, erythematöse Plaques im Gesicht, die zunächst als Lupus tumidus angesehen wurden (n = 2), pseudotumorale Läsionen, die klinisch eine MF im Tumorstadium vortäuschten (n = 1), dauerhafte Exkoriationen (n = 1), erythematöse, Rosazea‐artige Papeln im Gesicht (n = 1) sowie kuppelförmige, asymptomatische, mit Muzin gefüllte (in der Histologie) Papeln/Knoten (n = 2), die andere krankheitsbedingte Läsionen überlagerten. Es kamen mehrere Therapieansätze mit unterschiedlichem Ergebnis zur Anwendung. Acht (29,6 %) Patienten hatten FMF im Spätstadium.SchlussfolgerungenDas Bewusstsein für vernachlässigte klinische Symptome kann wesentlich dazu beitragen, verspätete Diagnosen dieser aggressiven MF‐Variante zu verringern.
Using species distribution models to locate animal aggregations: a case study withHippodamia undecimnotata(Schneider) overwintering aggregation sites
Authors: SUSSET ELINE C. , MAGRO ALEXANDRA , HEMPTINNE JEAN‐LOUIS 
Published: March 2017

1. The protection of animals' aggregation sites is increasingly seen as a key conservation strategy. However, to efficiently protect aggregation sites, they need to be accurately located. Species distribution models (SDMs) are an important tool in biological conservation to predict spatial distribution of species and they are used here to predict the distribution of the aggregation sites of a ladybird (Coleoptera:Coccinellidae) species.2.Hippodamia undecimnotataforms spectacular overwintering aggregations at the same locations every year across southern and easternEurope. In this study, anSDMwas developed and its performance tested forH. undecimnotataaggregations in southwestFrance. Moreover, the study looked at how environmental variables correlate with ladybirds' abundance in the aggregation sites.3. The occurrence of aggregations was best described by one model including isolated prominent object, pesticide risk, altitude and vegetation coverage. Furthermore, ladybird abundance at the aggregation sites is positively correlated with altitude. TheSDMoccurrence model performance was found to be high (area under the curve = 0.92 and true skill statistic = 0.78).4. It is suggested thatH. undecimnotatamay be an umbrella species, because some aggregation sites were also used by other ladybird species. Therefore, the protection of the aggregation sites of this species may benefit several other species.5. This study provides nature conservation stakeholders with a tool to locate overwintering aggregations, a first step towards the protection of these sites.
Risk factors for vascular complications and treatment patterns at diagnosis of 2389 PV and ET patients: Real‐world data from the Swedish MPN Registry
Authors: Abdulkarim Khadija , Samuelsson Jan , Johansson Peter , Andréasson Björn 
Published: March 2017

AbstractObjectiveThe study mainly aimed at investigating possible correlations between peripheral blood counts, erythropoietin (EPO), JAK2 V617F mutation, and vascular complications prior to diagnosis of a population‐based cohort of newly diagnosed patients with myeloproliferative neoplasms (MPN).MethodThe study comprises 1105 patients with polycythemia vera (PV) and 1284 patients with essential thrombocythemia (ET) registered in the Swedish MPN Registry.ResultsVascular complications, prior to diagnosis, were registered in 37% of PV patients. In multivariate analysis, low hemoglobin was the only significant risk factor (P=.0120). Among ET patients, 35% had encountered a vascular complication. Risk factors for thromboembolic complications in ET were identified as age>65 years, white cell count>12×109/L, and the presence of JAK2 V617F mutation (P=.0004, P=.0038, and P=.0016, respectively). A JAK2 V617F mutation was present in 71% of ET patients with vascular complications, compared to 60% in patients without. A majority of complications were thromboembolic, in both PV and ET.ConclusionWe conclude that vascular complications among newly diagnosed patients had affected more than one‐third of our study population. Risk factors for vascular complications prior to diagnosis were lower hemoglobin in PV, and the presence of JAK2 V617F mutation, higher age, and leukocytosis in ET.
BNIP3 promotes the motility and migration of keratinocyte under hypoxia
Authors: Zhang Junhui , Zhang Dongxia , Yan Tiantian , Jiang Xupin , Zhang Can , Zhao Liping , Li Lingfei , Tang Di , Zhang Qiong , Jia Jiezhi , Zhang Jiaping , Huang Yuesheng 
Published: March 2017

AbstractThe migration of keratinocytes from wound margins plays a critical role in the re‐epithelialization of skin wounds. Hypoxia occurs immediately after injury and acts as an early stimulus to initiate the healing processes. Although our previous studies have revealed that hypoxia promotes keratinocyte migration, the precise mechanisms involved remain unclear. Here, we found that BNIP3 expression was upregulated in hypoxic keratinocytes, and BNIP3 silencing suppressed hypoxia‐induced cell migration. Additionally, hypoxia activated the focal adhesion kinase (FAK) pathway through upregulation of BNIP3, while FAK inhibition attenuated hypoxic keratinocyte migration. Here, we conclusively demonstrate a novel role for BNIP3 in hypoxia‐induced keratinocyte migration. Furthermore, we provide a new perspective on the molecular mechanisms of wound healing and identify BNIP3 as a potential new molecular target for clinical treatments to enhance wound healing.
The hurdle effect of osmotic pretreatment and high‐pressure cold pasteurisation on the shelf‐life extension of fresh‐cut tomatoes
Authors: Dermesonlouoglou Efimia K. , Andreou Varvara , Alexandrakis Zacharias , Katsaros George J. , Giannakourou Maria C. , Taoukis Petros S. 
Published: March 2017

AbstractTomatoes are perishable products due to the activity of microorganisms and endogenous enzymes. The objective was to produce cut tomatoes with extended shelf life, using the combined hurdle effect of osmotic pretreatment (OD) and high pressure (HP), instead of a conventional one‐step thermal process. Samples were processed in a multicomponent osmotic solution at 35 °C, subsequently cold‐pasteurised in pack at 600 MPa and stored at 5–15 °C. Quality deterioration during isothermal and nonisothermal storage was kinetically modelled. Both OD process and OD‐HP combined process caused an increase in lycopene content that was well retained. Texture, colour and flavour of treated samples were evaluated as similar to fresh, with OD‐HP samples showing better retention during storage. Being microbiologically stable, shelf life of OD‐HP samples was limited by sensory deterioration, whereas OD samples were rejected due to eventual microbial growth. Shelf life of OD and OD‐HP samples was estimated at 77 and 181 days, respectively, at 5 °C.
Effect of high‐pressure treatments prior to cooking on gelling properties of unwashed protein from barramundi (Lates calcarifer) minced muscle
Authors: Truong Binh Q. , Buckow Roman , Nguyen Minh H. , Furst John 
Published: March 2017

SummaryHeat‐induced gelling properties of barramundi minced muscle with 1.5% and 2% added salt were assessed after application of pressures at 300, 400 and 500 MPa at 4 °C (initial temperature) for 10 min and subsequent cooking at 90 °C for 30 min. Whiteness, gel‐forming ability, water‐holding capacity, hardness and springiness of the barramundi gels increased as applied pressure and salt concentration increased. At 2% salt concentration, high‐pressure treatment results in barramundi gels with higher gel strength, mechanical properties and smoother texture as compared to conventional heat‐induced gels (0.1 MPa, 90 °C for 30). At a reduced salt concentration (1.5%) and pressure ≥ 400 MPa, the quality (gel strength, water‐holding capacity, hardness and springiness) of pressurised cooked gels is comparable to those heat‐induced gels with 2% added salt, but the microstructure is smoother. Scanning electron microscope images of pressurised cooked gels showed dense and compact network with smoother surface than those of heat‐only‐induced gels. Thus, application of high‐pressure treatment prior to cooking could be an effective method to enable reduced salt concentration in barramundi gels.
Escherichia coli biotransformation of daidzein fermentation products from soy‐based foods—relevance to food oestrogenicity‐based functionality
Authors: Ye Hui , Dudley Samantha Z. , Shaw Ian C. 
Published: March 2017

SummaryOestrogenic isoflavones (e.g. daidzein) present in soy‐based foods are likely to be important in food functionality. Biotransformation of daidzein during fermentation‐based soy‐containing food manufacture forms three trihydroxy metabolites, 6‐ortho‐hydroxydaidzein (6‐OHD), 8‐ortho‐hydroxydaidzein (8‐OHD) and 3′‐ortho‐hydroxydaidzein (3′‐OHD) which alters the oestrogenicity of the final food product. We report that Escherichia coli (a key component of the gut microbiome) metabolism converts 8‐OHD to 6‐OHD with a likely concomitant increase in oestrogenicity. This means that the functionality of 8‐OHD‐containing soy‐based foods is altered by gut microbiome metabolism. This change in oestrogenicity‐based food functionality might have benefits for postmenopausal women, while being a feminising health risk for males and could add to the risk of oestrogen‐mediated precocious puberty in girls.
White‐emitting phosphor Ba2B2O5:Ce3+, Tb3+, Sm3+: Luminescence, energy transfer, and thermal stability
Authors: Xu Shuchao , Wang Zhijun , Li Panlai , Li Ting , Bai Qiongyu , Sun Jiang , Yang Zhiping 
Published: March 2017

AbstractA series of Ba2B2O5: RE (RE=Ce3+/Tb3+/Sm3+) phosphors were synthesized using high‐temperature solid‐state reaction. The X‐ray diffraction (XRD), luminescent properties, and decay lifetimes are utilized to characterize the properties of the phosphors. The obtained phosphors can emit blue, green, and orange‐red light when single‐doped Ce3+, Tb3+, and Sm3+. The energy can transfer from Ce3+to Tb3+and Tb3+to Sm3+in Ba2B2O5, but not from Ce3+to Sm3+in Ce3+and Sm3+codoped in Ba2B2O5. However, the energy can transfer from Ce3+to Sm3+through the bridge role of Tb3+. We obtain white emission based on energy transfer of Ce3+→Tb3+→Sm3+ions. These results reveal that Ce3+/Tb3+/Sm3+can interact with each other in Ba2B2O5, and Ba2B2O5may be a potential candidate host for white‐light‐emitting phosphors.
Initial psychometric testing and validation of the patient participation in pressure injury prevention scale
Authors: Chaboyer Wendy , Harbeck Emma , Bucknall Tracey , McInnes Elizabeth , Thalib Lukman , Whitty Jennifer , Wallis Marianne , Gillespie Brigid 
Published: March 2017

AbstractAimsThe aim of this study was to develop the Patient Participation in Pressure injury Prevention (PPPIP) scale and undertake initial testing of some of its psychometric properties.BackgroundClinical practice guidelines recommend patient involvement in pressure injury prevention. There is some evidence that patients are willing to participate in this activity, but there are currently no instruments to measure this participation.DesignThis methodological study used data collected as part of a cluster randomized trial to develop and test the PPPIP scale.MethodsA sample of 688 of patients with complete PPPIP scale data was used. A stratified random subsample, (Subsample A) was created and the remainder became Subsample B. Item analysis, exploratory factor analysis and Cronbach's alpha reliability were undertaken in Subsample A. Confirmatory factor analysis and Cronbach's alpha reliability were undertaken in Subsample B. Data collection occurred between June 2014 ‐ May 2015.ResultsIn Subsample A (n = 320), inter‐item correlations, item total correlations met the acceptance criteria and an exploratory factor analysis identified a one factor solution. In Subsample B (n = 368), the confirmatory factor analysis supported this one factor. In both subsamples, the Cronbach's alpha was 0·86.ConclusionThis study provides preliminary evidence of acceptable reliability and validity of the PPPIP scale in two subsamples of hospitalized patients who had limited mobility. It may be used in research and quality improvement activities. As a better conceptual understanding of patient participation emerges, the PPPIP scale may require refinement.
Corporate Innovation Strategy, Analyst Forecasting Activities and the Economic Consequences
Authors: Jia Ning 
Published: March 2017

AbstractWe examine the impact of corporate innovation strategy on analyst following and forecasting performance, as well as the associated economic consequences. Using a sample of US firms from 1992−2012, we find that firms pursuing an exploration‐oriented innovation strategy (as opposed to an exploitation‐oriented innovation strategy) are associated with lower analyst coverage, higher forecast error and dispersion. The effect is less pronounced for firms with greater disclosure of innovation activities, and for firms followed by analysts with more firm‐specific experience. We also examine how innovation strategy affects the perceived credibility of analyst forecasts and find that investors appear to be less responsive to forecast revisions issued for exploratory firms. Such firms also incur a higher level of cash holdings, greater internal financing, and lower dividend ratio. The findings of this paper advance our understanding of how a public company's choice of innovation strategy affects its performance in the capital markets as well as the associated economic consequences.
Quality of life and comorbidities in palmoplantar pustulosis – a cross‐sectional study on 102 patients
Authors: Trattner H. , Blüml S. , Steiner I. , Plut U. , Radakovic S. , Tanew A. 
Published: March 2017

AbstractBackgroundAssociation of palmoplantar pustulosis (PPP) with metabolic and autoimmune diseases has been reported in mostly small case series or anecdotal cases.ObjectiveTo assess health‐related quality of life and prevalence of comorbidities in a large cohort of PPP patients.MethodsWe conducted a cross‐sectional study on patients with either active or past PPP. Disease severity was measured by the Palmoplantar Pustulosis Area and Severity Index (ppPASI). Quality of life was assessed by the Dermatology Life Quality Index (DLQI). Comorbidities were evaluated by medical history, blood examination, stool testing for Helicobacter pylori antigen and screening tools for depression and psoriatic arthritis.ResultsA total of 102 patients (87 women, 15 men) with a mean age of 52.6 ± 14.1 years were evaluated. The mean DLQI was 7 ± 6. Comorbidities were frequent and consisted of hypercholesterolaemia (38%), hypertension (32%), obesity (27%), metabolic syndrome (26%), depression (24%), diabetes (19%), autoimmune thyroiditis (16%) and psoriatic arthritis (16%).ConclusionPatients with PPP have an impaired quality of life and a broad range of comorbidities. Contrary to other reports, our investigation failed to show an association between PPP and coeliac disease or H. pylori infection.
Clinicians guide for cue‐based transition to oral feeding in preterm infants: An easy‐to‐use clinical guide
Authors: Lubbe Welma 
Published: March 2017

AbstractRationale, aims and objectivesThis article aims to provide evidence to guide multidisciplinary clinical practitioners towards successful initiation and long‐term maintenance of oral feeding in preterm infants, directed by the individual infant maturity.MethodA comprehensive review of primary research, explorative work, existing guidelines, and evidence‐based opinions regarding the transition to oral feeding in preterm infants was studied to compile this document.ResultsCurrent clinical hospital practices are described and challenged and the principles of cue‐based feeding are explored. “Traditional” feeding regimes use criteria, such as the infant's weight, gestational age and being free of illness, and even caregiver intuition to initiate or delay oral feeding. However, these criteria could compromise the infant and increase anxiety levels and frustration for parents and caregivers. Cue‐based feeding, opposed to volume‐driven feeding, lead to improved feeding success, including increased weight gain, shorter hospital stay, fewer adverse events, without increasing staff workload while simultaneously improving parents' skills regarding infant feeding. Although research is available on cue‐based feeding, an easy‐to‐use clinical guide for practitioners could not be found. A cue‐based infant feeding regime, for clinical decision making on providing opportunities to support feeding success in preterm infants, is provided in this article as a framework for clinical reasoning.ConclusionsCue‐based feeding of preterm infants requires care providers who are trained in and sensitive to infant cues, to ensure optimal feeding success. An easy‐to‐use clinical guideline is presented for implementation by multidisciplinary team members. This evidence‐based guideline aims to improve feeding outcomes for the newborn infant and to facilitate the tasks of nurses and caregivers.
Isolation, identification and pathogenicity of Vibrio harveyi, the causal agent of skin ulcer disease in juvenile hybrid groupers Epinephelus fuscoguttatus × Epinephelus lanceolatus
Authors: Shen G M , Shi C Y , Fan C , Jia D , Wang S Q , Xie G S , Li G Y , Mo Z L , Huang J 
Published: March 2017

AbstractThe hybrid grouper, Epinephelus fuscoguttatus (♀) × Epinephelus lanceolatus (♂), is a newly bred cultivated marine fish species of high economic value. However, a skin ulcer disease with high mortality has occurred, and the responsible pathogen remains unknown. In this study, we summarized the epidemic status and external signs of this disease. We screened potential pathogens and finally isolated one bacterial strain ML01 from affected fish. We subjected healthy juvenile hybrid groupers to bacterial challenge tests with the isolate by immersion, immersion after dermal abrasion and intraperitoneal injection, respectively. Within 14 days post‐infection, the isolate ML01 caused mass mortality of juveniles infected via immersion after dermal abrasion or intraperitoneal injection. Diseased juveniles displayed obvious signs of skin ulcers. The median lethal dose of ML01 by intraperitoneal injection was 1.10 × 105 colony‐forming units. ML01 was identified as Vibrio harveyi by bacterial morphology, analytical profile index identification, 16S rDNA sequencing and multilocus sequence analysis. Antibiotic susceptibility tests showed that ML01 was sensitive to ceftriaxone, doxycycline and minocycline. The results of this study suggest that V. harveyi is the causal agent of skin ulcer disease in juvenile hybrid groupers, thus providing a basis for effective control and prevention of this disease.
Immigrant Family Resilience in Context: Using a Community‐Based Approach to Build a New Conceptual Model
Authors: Vesely Colleen K. , Letiecq Bethany L. , Goodman Rachael D. 
Published: March 2017

AbstractImmigrant families settling in the United States face pressures to acculturate and become self‐sufficient, yet their lives are highly regulated by restrictive and punitive policies and programs that may hinder their ability to cope with exposure to trauma and to build resilience. We theorize that U.S. policies and practices may exacerbate immigration‐related trauma experiences and/or create new traumas and stressors for families. To demonstrate our reasoning, we use exemplar cases from our community‐based participatory research project in partnership with immigrant women. We situate and contextualize the lived experiences and uncertainties of immigrant families and offer a new conceptual model for understanding how macro‐level forces may impede immigrants' resilience. The model includes uncertainty and family separation; ecosystemic trauma and stress, including institutional betrayal trauma; limited navigational capital; and erosion of collectivism and community solidarity. Implications for future research and theory development are discussed.
Research on Correlates of Marital Quality and Stability in Muslim Countries: A Review
Authors: Sabour Esmaeili Nooshin , Schoebi Dominik 
Published: March 2017

AbstractThe study of marital quality and stability has attracted widespread attention over the past two decades, with considerable interest in identifying predictors of marital quality and (in)stability. Most of this research comes from Western countries, however, and similar research from other areas is only beginning to develop. In particular, little coherent literature in this area has emerged from Muslim countries. Understanding how marriages develop, succeed, and fail is important for families across the globe, and perspectives relying predominantly on Western data and research perspectives may be of limited use in other contexts. The current review summarizes the existing empirical literature on the basis of samples from predominantly Muslim countries; identifies existing evidence to reveal important gaps with particular emphasis on personal, interpersonal, and contextual factors; and explores potential mechanisms that might explain associations between these factors and indicators of marital functioning.
Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex
Authors: Tsuda Makoto , Koga Kohei , Chen Tao , Zhuo Min 
Published: March 2017

AbstractNeuropathic pain is a debilitating chronic pain condition occurring after damage in the nervous system and is refractory to the currently available treatments. Major challenges include elucidating its mechanisms and developing new medications to treat it. Nerve injury‐induced pain hypersensitivity involves aberrant excitability in spinal dorsal horn (SDH) neurons as a consequence of dysfunction of inhibitory interneurons and of hyperactivity of glial cells, especially microglia, the immune cells of the central nervous system. Evidence of this is found using animal models to investigate the molecular and cellular mechanisms of neuropathic pain. The pathologically altered somatosensory signals in the SDH then convey to the brain regions, including the anterior cingulate cortex (ACC). In these regions, nerve injury produces pre‐ and postsynaptic long‐term plasticity, which contributes to negative emotions and anxiety associated with chronic pain conditions. Furthermore, recent evidence also indicates that the descending projection pathways from the ACC directly and indirectly to the SDH (the top‐down corticospinal network) regulate nociceptive sensory transmission in the SDH. Thus, understanding a possible connection between the SDH and ACC, including a neuron–microglia interaction, may provide us with insights into the mechanisms used to amplify pain signals related to neuropathic pain and clues to aid the development of new therapeutic agents for the management of chronic pain.This article is part of the special article series “Pain”.
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