bluuebunny/crossref_metadata_2025_split huggingface dataset:
CYSTOID MACULAR EDEMA SECONDARY TO RITUXIMAB
Authors: Gilca Marina , Merrill Pauline T. 
Published: March 2017

Background/Purpose:
To describe a case of bilateral macular edema appearing after treatment with rituximab.

Methods:
This is a case report describing macular edema after rituximab infusions. The information was collected retrospectively through chart review.

Results:
A 53-year-old patient known for IgG4-related disease of the face and sinuses presented with bilateral decreased visual acuity from cystoid macular edema shortly after undergoing two rituximab infusions. Laboratory workup did not reveal any underlying systemic etiology. Treatment with topical and oral corticosteroids as well as with anti–vascular endothelial growth factor injections led to mild improvement. Treatment with intraocular triamcinolone resulted in complete resolution of the edema, although accompanied by an increase in intraocular pressure.

Conclusion
Rituximab has been previously associated with macular edema. Macular edema causing visual loss shortly after receiving rituximab may respond to discontinuation of the rituximab and local steroid injection.
When Interactions Between Young Children and Dogs Become Dangerous
Authors: Warner Holly , Schilling Samantha 
Published: March 2017

Abstract
Dog bites are an important public health problem and often require significant medical and surgical care, especially among younger children. Although decades of research and clinical experience have revealed specific risk factors and potential avenues for the prevention of dog bite injuries to children, the problem remains widespread and serious. Prevention efforts underway largely target older children with limited focus on how to protect the infants and toddlers who experience the most serious morbidity and mortality from dog bite injuries. Recent research on the relationship between parent supervision and dog bites highlights an opportunity to educate parents on the risk of dog bites and appropriate dog–child interaction. The overall goal of such efforts is to reduce the frequency of dog bites, thus protecting children and avoiding hospital and surgical treatment.
Traumatic brain injury in the Netherlands, trends in emergency department visits, hospitalization and mortality between 1998 and 2012
Authors: Van den Brand Crispijn L. , Karger Lennard B. , Nijman Susanne T.M. , Hunink Myriam G.M. , Patka Peter , Jellema Korné 
Published: March 2017

Background
Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide. The effects of epidemiological changes such as ageing of the population and increased traffic safety on the incidence of TBI are unknown.

Objective
The objective of this study was to evaluate trends in TBI-related emergency department (ED) visits, hospitalization and mortality in the Netherlands between 1998 and 2012.

Design
This was a retrospective observational, longitudinal study.

Main outcome measures
The main outcome measures were TBI-related ED visits, hospitalization and mortality.

Results
Between 1998 and 2012, there were 500 000 TBI-related ED visits in the Netherlands. In the same period, there were 222 000 TBI-related admissions and 17 000 TBI-related deaths. During this period, there was a 75% increase in ED visits for TBI and a 95% increase for TBI-related hospitalization; overall mortality because of TBI did not change significantly. Despite the overall increase in TBI-related ED visits, this increase was not evenly distributed among age groups or trauma mechanisms. In patients younger than 65 years, a declining trend in ED visits for TBI caused by road traffic accidents was observed. Among patients 65 years or older, ED visits for TBI caused by a fall increased markedly. TBI-related mortality shifted from mainly young (67%) and middle-aged individuals (<65 years) to mainly elderly (63%) individuals (≥65 years) between 1998 and 2012. The conclusions of this study did not change when adjusting for changes in age, sex and overall population growth.

Conclusion
The incidence of TBI-related ED visits and hospitalization increased markedly between 1998 and 2012 in the Netherlands. TBI-related mortality occurred at an older age. These observations are probably the result of a change in aetiology of TBI, specifically a decrease in traffic accidents and an increase in falls in the ageing population. This hypothesis is supported by our data. However, ageing of the population is not the only cause of the changes observed; the observed changes remained significant when correcting for age and sex. The higher incidence of TBI with a relatively stable mortality rate highlights the importance of clinical decision rules to identify patients with a high risk of poor outcome after TBI.
Big and disparate data: considerations for pediatric consortia
Authors: Stingone Jeanette A. , Mervish Nancy , Kovatch Patricia , McGuinness Deborah L. , Gennings Chris , Teitelbaum Susan L. 
Published: March 2017

Purpose of review
Increasingly, there is a need for examining exposure disease associations in large, diverse datasets to understand the complex determinants of pediatric disease and disability. Recognizing that children's health research consortia will be important sources of big data, it is crucial for the pediatric research community to be knowledgeable about the challenges and opportunities that they will face. The present review will provide examples of existing children's health consortia, highlight recent pooled analyses conducted by children's health research consortia, address common challenges of pooled analyses, and provide recommendations to advance collective research efforts in pediatric research.

Recent findings
Formal consortia and other collective-science initiatives are increasingly being created to share individual data from a set of relevant epidemiological studies to address a common research topic under the concept that the joint effort of many individual groups can accomplish far more than working alone. There are practical challenges to the participation of investigators within consortia that need to be addressed in order for them to work.

Summary
Researchers who access consortia with data centers will be able to go far beyond their initial hypotheses and potentially accomplish research that was previously thought infeasible or too costly.
Surgical Management of Crohn Disease in Children
Authors: Amil‐Dias Jorge , Kolacek Sanja , Turner Dan , Pærregaard Anders , Rintala Risto , Afzal Nadeem A. , Karolewska‐Bochenek Katarzyna , Bronsky Jiri , Chong Sonny , Fell John , Hojsak Iva , Hugot Jean‐Pierre , Koletzko Sibylle , Kumar Devinder , Lazowska‐Przeorek Izabella , Lillehei Craig , Lionetti Paolo , Martin‐de‐Carpi Javier , Pakarinen Mikko , Ruemmele Frank M. , Shaoul Ron , Spray Christine , Staiano Annamaria , Sugarman Ian , Wilson David C. , Winter Harland , Kolho Kaija‐Leena ,   IBD Working Group of ESPGHAN (IBD Porto Group)
Published: March 2017

ABSTRACTThe incidence of Crohn disease (CD) has been increasing and surgery needs to be contemplated in a substantial number of cases. The relevant advent of biological treatment has changed but not eliminated the need for surgery in many patients. Despite previous publications on the indications for surgery in CD, there was a need for a comprehensive review of existing evidence on the role of elective surgery and options in pediatric patients affected with CD. We present an expert opinion and critical review of the literature to provide evidence‐based guidance to manage these patients. Indications, surgical options, risk factors, and medications in pre‐ and perioperative period are reviewed in the light of available evidence. Risks and benefits of surgical options are addressed. An algorithm is proposed for the management of postsurgery monitoring, timing for follow‐up endoscopy, and treatment options.
Innovative beer-brewing of typical, old and healthy wheat varieties to boost their spreading
Authors: Albanese Lorenzo , Ciriminna Rosaria , Meneguzzo Francesco , Pagliaro Mari 
Published: March 2017

AbstractCertain typical old wheat varieties grown in the Mediterranean countries and elsewhere are renowned for their nutritional value due to higher concentration of polyphenols, especially flavonoids, as well as of important minerals, than modern varieties. However, the respective economical sustainability is constrained by reduced yield, increasing costs and stagnating or decreasing market prices. Moreover, under certain conditions, connected with the respective scale and local market volume, low-input, organically grown cereals can lead to lower environmental footprint. Brewing with a portion of such old grains can effectively boost their spreading, conditioned on its ability to supply a significant additional net income to farmers. Beer has become the worldwide most consumed alcoholic beverage and, although its market is dominated by few global players and standardized products, craft breweries have quickly spread out in most countries. Nevertheless, a scale issue has arisen about the economic sustainability of microbreweries, mainly due to high initial capital investment, energy costs, scale, and sometimes taxation. It is shown how breakthrough, cheaper, more efficient and profitable microbreweries can help solving the sustainability issues affecting old wheat varieties, thus boosting the respective spreading, lowering the environmental footprint of the cereal sector and contributing to improve the public health.
Whole genome methylation analysis of non-dysplastic Barretts oesophagus that progresses to invasive cancer
Authors: Dilworth MP , Nieto T , Stockton JD , Whalley C , Tee L , James JD , Hallissey MT , Hejmadi R , Trugdill N , Tucker O , Beggs AD 
Published: March 2017

ABSTRACTObjectiveTo investigate differences in methylation between patients with non-dysplastic Barretts’ oesophagus who progress to invasive adenocarcinoma and those that do not.DesignA whole genome methylation interrogation using the Illumina HumanMethylation 450 array of patients with non-dysplastic Barrett’s Oesophagus who either develop adenocarcinoma or remain static, with validation of findings by bisulfite pyrosequencingResultsIn total, 12 patients with “progressive” vs. 12 with “non-progressive” non-dysplastic Barrett’s oesophagus were analysed via methylation array. Fourty-four methylation markers were identified that may be able to discriminate between non-dysplastic Barrett’s Oesophagus that either progress to adenocarcinoma or remain static. Hypomethylation of the recently identified tumour supressorOR3A4(probe cg09890332) validated in a separate cohort of samples (median methylation in progressors = 67.8% vs. 96.7% in non-progressors,p=0.0001, z = 3.85, Wilcoxon rank sum test) and was associated with the progression to adenocarcinoma. There were no differences in copy number between the two groups, but a global trend towards hypomethylation in the progressor group was observed.ConclusionHypomethylation ofOR3A4has the ability to risk stratify the patient with non-dysplastic Barrett’s Oesophagus and may form the basis of a future surveillance program.
Cell cycle entry triggers a switch between two modes of Cdc42 activation during yeast polarization
Authors: Witte Kristen , Strickland Devin , Glotzer Michael 
Published: March 2017

AbstractCell polarization underlies many cellular and organismal functions. The GTPase Cdc42 orchestrates polarization in many contexts. In budding yeast, polarization is associated with a focus of Cdc42•GTP which is thought to self sustain by recruiting a complex containing Cla4, a Cdc42-binding effector, Bem1, a scaffold and Cdc24, a Cdc42 GEF. Using optogenetics, we probe yeast polarization and find that local recruitment of Cdc24 or Bem1 is sufficient to induce polarization by triggering self-sustaining Cdc42 activity. However, the response to these perturbations depends on the recruited molecule, the cell cycle stage, and existing polarization sites. Before cell cycle entry, recruitment of Cdc24, but not Bem1, induces a metastable pool of Cdc42 that is sustained by positive feedback. Upon Cdk1 activation, recruitment of either Cdc24 or Bem1 creates a stable site of polarization that induces budding and inhibits formation of competing sites. Local perturbations have therefore revealed unexpected features of polarity establishment.
Satellite formation keeping via chaotic artificial bee colony
Authors: Olukunle Kolawole Soyinka , Haibin Duan 
Published: March 2017

Purpose
Keeping satellite position within close tolerances is key for the utilization of satellite formations for space missions. The presence of perturbation forces makes control inevitable if such mission objective is to be realised. Various approaches have been used to obtain feedback controller parameters for satellites in a formation; this paper aims to approach the problem of estimating the optimal feedback parameter for a leader–follower pair of satellites in a small eccentric orbit using nature-based search algorithms.

Design/methodology/approach
The chaotic artificial bee colony algorithm is a variant of the basic artificial bee colony algorithm. The algorithm mimics the behaviour of bees in their search for food sources. This paper uses the algorithm in optimizing feedback controller parameters for a satellite formation control problem. The problem is formulated to optimize the controller parameters while minimizing a fuel- and state-dependent cost function. The dynamical model of the satellite is based on Gauss variational equations with J2 perturbation. Detailed implementation of the procedure is provided, and experimental results of using the algorithm are also presented to show feasibility of the method.

Findings
The experimental results indicate the feasibility of this approach, clearly showing the effective control of the transients that arise because of J2 perturbation.

Originality/value
This paper applied a swarm intelligence approach to the problem of estimating optimal feedback control parameter for a pair of satellites in a formation.
A missile guidance law tolerant to unestimated evasive maneuvers
Authors: Marzat Julien 
Published: March 2017

Purpose
This note aims to introduce a terminal guidance law that is able to compensate for evasive target maneuvers without estimating their acceleration.

Design/methodology/approach
The new guidance law is derived in the framework of linear-quadratic optimal control to ensure interception with minimum energy even in the presence of a target maneuver.

Findings
An explicit closed-form expression for the missile acceleration command is provided, which turns out to be a non-trivial extension of proportional navigation guidance. Simulation results against evasive maneuvers of various intensities are provided to compare the new law to classical ones and thus show the benefits of the proposed approach.

Originality/value
The proposed guidance law was not reported so far in the literature and provides a simple way to deal with evasive maneuvers.
Young service users from refugee backgrounds: their perspectives on barriers to accessing Australian mental health services
Authors: Valibhoy Madeleine Claire , Szwarc Josef , Kaplan Ida 
Published: March 2017

PurposeThe purpose of this paper is to examine barriers to accessing mental health services, from the perspective of young people of refugee background who have been service users, and to suggest strategies to improve access to mental health services.Design/methodology/approachA qualitative study was conducted with 16 young people (aged 18-25), who had been refugees and who had attended mental health professionals in Australia. Interview transcripts were analysed thematically to examine participants’ perspectives on what hinders initial access to mental health services.FindingsStigma about mental health problems was particularly prominent. Many believed a high level of disturbance was the threshold for entering services, and for some there was no knowledge of such services’ existence. Options for assistance other than mental health services were often preferred, according to young people’s explanatory models. Apprehension was expressed that sessions would be uncomfortable, distressing or ineffective. The desire to be self-reliant functioned as a further barrier. Finally, structural obstacles and social exclusion deterred some young refugees from accessing services.Practical implicationsImplications include the need for service providers to be equipped to provide culturally sensitive, responsive services that ideally offer both practical and psychological assistance. Potential referrers, including health professionals and community leaders, could facilitate increased access if trained to recognise and address barriers. Finally, findings indicate potential content for awareness-raising initiatives for young refugees about mental health problems and services.Originality/valueThis paper is original in its sample, method, topic and findings; being drawn from the first known qualitative research exploring views of young mental health service users who have been refugees about barriers to accessing mental health services.
Influence of job characteristics on engagement: does support at work act as moderator?
Authors: Rai Alka , Ghosh Piyali , Chauhan Ragini , Mehta Navin Kumar 
Published: March 2017

PurposeIndian banking industry is one the biggest players in the country’s service sector, with public sector banks (PSBs) occupying the major share. The purpose of this paper is to develop a model linking job characteristics (JC) and work engagement, moderated by perceived organizational and supervisor support as contextual variables.Design/methodology/approachData on 214 employees from 15 PSBs were used to examine this model. Analysis of data has established the moderating role of support at work in the relationship between JC and work engagement.FindingsFindings suggest that employees who have a positive perception of organizational and supervisor support are more likely to respond positively to JC and therefore would have a higher propensity to engage with their jobs. In addition to enriched jobs, the wider organizational climate characterized by support from supervisors and organization as a whole is critical to establish a positive environment, which would lead to greater work engagement.Originality/valueThe moderating role of support at workplace on JC and work engagement has been researched very rarely in literature. This study, hence, aims at investigating whether interaction between JC and perceived organizational and supervisor support influences work engagement of employees working in Indian PSBs.
Big data text analytics: an enabler of knowledge management
Authors: Khan Zaheer , Vorley Tim 
Published: March 2017

PurposeThe purpose of this paper is to examine the role of big data text analytics as an enabler of knowledge management (KM). The paper argues that big data text analytics represents an important means to visualise and analyse data, especially unstructured data, which have the potential to improve KM within organisations.Design/methodology/approachThe study uses text analytics to review 196 articles published in two of the leading KM journals –Journal of Knowledge ManagementandJournal of Knowledge Management Research & Practice– in 2013 and 2014. The text analytics approach is used to process, extract and analyse the 196 papers to identify trends in terms of keywords, topics and keyword/topic clusters to show the utility of big data text analytics.FindingsThe findings show how big data text analytics can have a key enabler role in KM. Drawing on the 196 articles analysed, the paper shows the power of big data-oriented text analytics tools in supporting KM through the visualisation of data. In this way, the authors highlight the nature and quality of the knowledge generated through this method for efficient KM in developing a competitive advantage.Research limitations/implicationsThe research has important implications concerning the role of big data text analytics in KM, and specifically the nature and quality of knowledge produced using text analytics. The authors use text analytics to exemplify the value of big data in the context of KM and highlight how future studies could develop and extend these findings in different contexts.Practical implicationsResults contribute to understanding the role of big data text analytics as a means to enhance the effectiveness of KM. The paper provides important insights that can be applied to different business functions, from supply chain management to marketing management to support KM, through the use of big data text analytics.Originality/valueThe study demonstrates the practical application of the big data tools for data visualisation, and, with it, improving KM.
How the Internet of Things can help knowledge management: a case study from the automotive domain
Authors: Uden Lorna , He Wu 
Published: March 2017

Purpose
Current knowledge management (KM) systems cannot be used effectively for decision-making because of the lack of real-time data. This study aims to discuss how KM can benefit by embedding Internet of Things (IoT).

Design/methodology/approach
The paper discusses how IoT can help KM to capture data and convert data into knowledge to improve the parking service in transportation using a case study.

Findings
This case study related to intelligent parking service supported by IoT devices of vehicles shows that KM can play a role in turning the incoming big data collected from IoT devices into useful knowledge more quickly and effectively.

Originality/value
The literature review shows that there are few papers discussing how KM can benefit by embedding IoT and processing incoming big data collected from IoT devices. The case study developed in this study provides evidence to explain how IoT can help KM to capture big data and convert big data into knowledge to improve the parking service in transportation.
Interrelationship between big data and knowledge management: an exploratory study in the oil and gas sector
Authors: Sumbal Muhammad Saleem , Tsui Eric , See-to Eric W.K. 
Published: March 2017

Purpose
The purpose of this paper is to explore the relationship between big data and knowledge management (KM).

Design/methodology/approach
The study adopts a qualitative research methodology and a case study approach was followed by conducting nine semi-structured interviews with open-ended and probing questions.

Findings
Useful predictive knowledge can be generated through big data to help companies improve their KM capability and make effective decisions. Moreover, combination of tacit knowledge of relevant staff with explicit knowledge obtained from big data improvises the decision-making ability.

Research limitations/implications
The focus of the study was on oil and gas sector, and, thus, the research results may lack generalizability.

Originality/value
This paper fulfills an identified need of exploring the relationship between big data and KM which has not been discussed much in the literature.
Davenport and Prusak on KM and big data/analytics: interview with David J. Pauleen
Authors: Pauleen David J. 
Published: March 2017

Purpose
Larry Prusak and Tom Davenport have long been leading voices in the knowledge management (KM) field. This interview aims to explore their views on the relationship between KM and big data/analytics.

Design/methodology/approach
An interview was conducted by email with Larry Prusak and Tom Davenport in 2015 and updated in 2016.

Findings
Prusak and Davenport hold differing views on the role of KM today. They also see the relationship between KM and big data/analytics somewhat differently. Davenport, in particular, has much to say on how big data/analytics can be best utilized by business as well as its potential risks.

Originality/value
It is important to understand how two of the most serious KM thinkers since the early years of KM understand the relationship between big data/analytics, KM and organizations. Their views can help shape thinking in these fields.