bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modal Objectivity1
Authors: Clarke‐Doane Justin 
Published: July 2017

AbstractIt is widely agreed that the intelligibility of modal metaphysics has been vindicated. Quine's arguments to the contrary supposedly confused analyticity with metaphysical necessity, and rigid with non‐rigid designators.2But even if modal metaphysics is intelligible, it could be misconceived. It could be that metaphysical necessity is not absolute necessity – the strictest real (non‐epistemic, non‐deontic) notion of necessity – and that no proposition of traditional metaphysical interest is necessary in every real sense. If there were nothing otherwise “uniquely metaphysically significant” about metaphysical necessity, then paradigmatic metaphysical necessities would be necessary in one sense of “necessary”, not necessary in another, and that would be it. The question of whether they were necessary simpliciter would be like the question of whether the Parallel Postulate is true simpliciter – understood as a pure mathematical conjecture, rather than as a hypothesis about physical spacetime. In a sense, the latter question has no objective answer. In this article, I argue that paradigmatic questions of modal metaphysics are like the Parallel Postulate question. I then discuss the deflationary ramifications of this argument. I conclude with an alternative conception of the space of possibility. According to this conception, there is no objective boundary between possibility and impossibility. Along the way, I sketch an analogy between modal metaphysics and set theory.
Situations and Responsiveness to Reasons*
Authors: Sartorio Carolina 
Published: July 2017

AbstractSome classical studies in social psychology suggest that we are more sensitive to situational factors, and less responsive to reasons, than we normally recognize we are. In recent years, moral responsibility theorists have examined the question whether those studies represent a serious threat to our moral responsibility. A common response to the “situationist threat” has been to defend the reasons‐responsiveness of ordinary human agents by appeal to a theory of reasons‐responsiveness that appeals to patterns of counterfactual scenarios or possible worlds. In this paper I identify a problem with that response and I offer a better solution.
Interacting effects of genetic variation for seed dormancy and flowering time on phenology, life history, and fitness of experimental Arabidopsis thaliana populations over multiple generations in the field
Authors: Taylor Mark A. , Cooper Martha D. , Sellamuthu Reena , Braun Peter , Migneault Andrew , Browning Alyssa , Perry Emily , Schmitt Johanna 
Published: July 2017

Summary

Major alleles for seed dormancy and flowering time are well studied, and can interact to influence seasonal timing and fitness within generations. However, little is known about how this interaction controls phenology, life history, and population fitness across multiple generations in natural seasonal environments.

To examine how seed dormancy and flowering time shape annual plant life cycles over multiple generations, we established naturally dispersing populations of recombinant inbred lines of Arabidopsis thaliana segregating early and late alleles for seed dormancy and flowering time in a field experiment. We recorded seasonal phenology and fitness of each genotype over 2 yr and several generations.

Strong seed dormancy suppressed mid‐summer germination in both early‐ and late‐flowering genetic backgrounds. Strong dormancy and late‐flowering genotypes were both necessary to confer a winter annual life history; other genotypes were rapid‐cycling. Strong dormancy increased within‐season fecundity in an early‐flowering background, but decreased it in a late‐flowering background. However, there were no detectable differences among genotypes in population growth rates.

Seasonal phenology, life history, and cohort fitness over multiple generations depend strongly upon interacting genetic variation for dormancy and flowering. However, similar population growth rates across generations suggest that different life cycle genotypes can coexist in natural populations.
Age‐related shifts in hemispheric dominance for syntactic processing
Authors: Leckey Michelle , Federmeier Kara D. 
Published: July 2017

AbstractRecent ERP data from young adults have revealed that simple syntactic anomalies elicit different patterns of lateralization in right‐handed participants depending upon their familial sinistrality profile (whether or not they have left‐handed biological relatives). Right‐handed participants who do not have left‐handed relatives showed a strongly lateralized response pattern, with P600 responses following left‐hemisphere‐biased presentations and N400 responses following right‐hemisphere‐biased presentations. Given that the literature on aging has documented a tendency to change across adulthood from asymmetry of function to a more bilateral pattern, we tested the stability of this asymmetric response to syntactic violations by recording ERPs as 24 older adults (age 60+) with no history of familial sinistrality made grammaticality judgments on simple two‐word phrases. Results showed that the asymmetric pattern observed in right‐handed adults without familial sinistrality indeed changes with age, such that P600 responses come to be elicited not only with left‐hemisphere‐biased but also with right‐hemisphere‐biased presentations in older adults. These findings suggest that, as with many other cognitive functions, syntactic processing becomes more bilateral with age.
Use of native and non‐native shrimp (Penaeidae, Dendrobranchiata) in world shrimp farming
Authors: Fernández de Alaiza García Madrigal Rafael , da Silva Ubiratã de Assis Teixeira , Tavares Camila Prestes dos Santos , Ballester Eduardo Luis Cupertino 
Published: July 2017

AbstractThe 2013 global farmed shrimp production totalled 4.3 million tons, whereas the production ofLitopenaeus vannameias non‐native species represented the 64% of that amount. The risks of introducing non‐native or exotic species are a growing environmental concern. Therefore, the objective of this study was to discuss updated information about the introduction of non‐native species and to evaluate the efficiency indicators of non‐native species in contrast to native ones. The results of a systematic revision of the publications about shrimp farming are presented, comparing the zootechnical performance of native and non‐native species, with the use of meta‐analysis tools. The conducted search returned 4680 results, corresponding to the articles that included one of the criteria previously established by the present work. Seven publications, which included 22 studies, met the requirements for the meta‐analysis. The effect size calculated was positive, meaning that, according to the considered data, the use of non‐native species resulted generally in higher values of growth rate in relation to the native species observed. Other aspects like the emergence and dissemination of the main viral diseases affecting global shrimp farming were also revised. We conclude that, although the advantages of using non‐native species, especiallyL. vannamei, over native species are clear, there are enough compelling evidences to support the viability of small‐scale native species farming. We also discussed why big companies, governments and associations related to the production and commerce of farmed shrimp should finance and support the development of native species farming.
Predictors of Emerging Suicide Death Among Military Personnel on Social Media Networks
Authors: Bryan Craig J. , Butner Jonathan E. , Sinclair Sungchoon , Bryan Anna Belle O. , Hesse Christina M. , Rose Andree E. 
Published: July 2017

Suicide is a leading cause of death in the United States and is the second leading cause of death in the U.S. military. Previous research suggests that data obtained from social media networks may provide important clues for identifying at‐risk individuals. To test this possibility, the social media profiles from 315 military personnel who died by suicide (n = 157) or other causes (n = 158) were coded for the presence of stressful life situations (i.e., triggers), somatic complaints or health issues (i.e., physical), maladaptive or avoidant coping strategies (i.e., behaviors), negative mood states (i.e., emotion), and/or negative cognitive appraisals (cognition). Content codes were subsequently analyzed using multilevel models from a dynamical systems perspective to identify temporal change processes characteristic of suicide death. Results identified temporal sequences unique to suicide, notably social media posts about triggers followed by more posts about cognitions, posts about cognitions followed by more posts about triggers, and posts about behaviors followed by fewer posts about cognitions. Results suggest that certain sequences in social media content may predict cause of death and provide an estimate of when a social media user is likely to die by suicide.
Genome Sequence of Zymomonas mobilis subsp.
mobilis
NRRL B-1960
Authors: Chacon-Vargas Katherine , Chirino Alexandra A. , Davis Meghan M. , Debler Sophia A. , Haimer Wynn Raphael , Wilbur Justin J. , Mo Xiaoli , Worthing Baxter W. , Wainblat Ethan G. , Zhao Shu , Gibbons John G. 
Published: July 2017

ABSTRACT

Zymomonas mobilis
subsp.
mobilis
is an efficient ethanol producer with application for industrial production of biofuel. To supplement existing
Z. mobilis
genomic resources and to facilitate genomic research, we used Oxford Nanopore and Illumina sequencing to assemble the complete genome of the beer spoilage isolate
Z. mobilis
subsp.
mobilis
strain NRRL B-1960.
Genome Sequence of the Dichloromethane-Degrading Bacterium
Hyphomicrobium
sp. Strain GJ21
Authors: Bringel Françoise , Postema Christiaan P. , Mangenot Sophie , Bibi-Triki Sabrina , Chaignaud Pauline , Farhan Ul Haque Muhammad , Gruffaz Christelle , Hermon Louis , Louhichi Yousra , Maucourt Bruno , Muller Emilie E. L. , Nadalig Thierry , Lajus Aurélie , Rouy Zoé , Médigue Claudine , Barbe Valérie , Janssen Dick B. , Vuilleumier Stéphane 
Published: July 2017

ABSTRACT

The genome sequence of
Hyphomicrobium
sp. strain GJ21, isolated in the Netherlands from samples of environments contaminated with halogenated pollutants and capable of using dichloromethane as its sole carbon and energy source, was determined.
Draft Genome Sequence of Enterococcus faecalis DD14, a Bacteriocinogenic Lactic Acid Bacterium with Anti-
Clostridium
Activity
Authors: Belguesmia Yanath , Leclère Valérie , Duban Matthieu , Auclair Eric , Drider Djamel 
Published: July 2017

ABSTRACT

We report the draft genome sequence of
Enterococcus faecalis
DD14, a strain isolated from meconium of a healthy newborn at Roubaix Hospital (France). The strain displayed antagonism against a set of Gram-positive bacteria through concomitant production of lactic acid and bacteriocin. The genome has a size of 2,893,365 bp and a 37.3% G+C ratio and is predicted to contain at least 2,755 coding sequences and 62 RNAs.
Draft Genome Sequence of Paenarthrobacter nicotinovorans Hce-1
Authors: Meng Jing , Sun Xiaomeng , Li Shuaishuai , Liang Hao 
Published: July 2017

ABSTRACT

Paenarthrobacter nicotinovorans
Hce-1 is a Gram-positive obligate aerobe actinomycete. We report here the complete genome sequence of this organism. The genome has a length of 4,174,362 bp and contains 4,568 protein-coding genes, 64 tRNA operons, and 22 rRNA operons. Its GC content in the gene region is 63.4%.
Ploidy Variation in Fungi: Polyploidy, Aneuploidy, and Genome Evolution
Authors: Todd Robert T. , Forche Anja , Selmecki Anna 
Published: July 2017

ABSTRACT
The ability of an organism to replicate and segregate its genome with high fidelity is vital to its survival and for the production of future generations. Errors in either of these steps (replication or segregation) can lead to a change in ploidy or chromosome number. While these drastic genome changes can be detrimental to the organism, resulting in decreased fitness, they can also provide increased fitness during periods of stress. A change in ploidy or chromosome number can fundamentally change how a cell senses and responds to its environment. Here, we discuss current ideas in fungal biology that illuminate how eukaryotic genome size variation can impact the organism at a cellular and evolutionary level. One of the most fascinating observations from the past 2 decades of research is that some fungi have evolved the ability to tolerate large genome size changes and generate vast genomic heterogeneity without undergoing canonical meiosis.
Profiles of children's social–emotional health at school entry and associated income, gender and language inequalities: a cross-sectional population-based study in British Columbia, Canada
Authors: Thomson Kimberly C , Guhn Martin , Richardson Chris G , Ark Tavinder K , Shoveller Jean 
Published: July 2017

ObjectivesEarly identification of distinct patterns of child social–emotional strengths and vulnerabilities has the potential to improve our understanding of child mental health and well-being; however, few studies have explored natural groupings of indicators of child vulnerability and strengths at a population level. The purpose of this study was to examine heterogeneity in the patterns of young children's social and emotional health and investigate the extent to which sociodemographic characteristics were associated.DesignCross-sectional study based on a population-level cohort.SettingAll kindergarten children attending public schools between 2004 and 2007 in British Columbia (BC), Canada.Participants35 818 kindergarten children (age of 5 years) with available linked data from the Early Development Instrument (EDI), BC Ministry of Health and BC Ministry of Education.Outcome measureWe used latent profile analysis (LPA) to identify distinct profiles of social–emotional health according to children's mean scores across eight social–emotional subscales on the EDI, a teacher-rated measure of children's early development. Subscales measured children's overall social competence, responsibility and respect, approaches to learning, readiness to explore, prosocial behaviour, anxiety, aggression and hyperactivity.ResultsSix social–emotional profiles were identified: (1) overall high social–emotional functioning, (2) inhibited-adaptive (3) uninhibited-adaptive, (4) inhibited-disengaged, (5) uninhibited-aggressive/hyperactive and (6) overall low social–emotional functioning. Boys, children with English as a second language (ESL) status and children with lower household income had higher odds of membership to the lower social–emotional functioning groups; however, this association was less negative among boys with ESL status.ConclusionsOver 40% of children exhibited some vulnerability in early social–emotional health, and profiles were associated with sociodemographic factors. Approximately 9% of children exhibited multiple co-occurring vulnerabilities. This study adds to our understanding of population-level distributions of children's early social–emotional health and identifies profiles of strengths and vulnerabilities that can inform future intervention efforts.
Common attributes in retired professional cricketers that may enhance or hinder quality of life after retirement: a qualitative study
Authors: Filbay Stephanie R , Bishop Felicity , Peirce Nicholas , Jones Mary E , Arden Nigel K 
Published: July 2017

ObjectivesRetired professional cricketers shared unique experiences and may possess specific psychological attributes with potential to influence quality of life (QOL). Additionally, pain and osteoarthritis can be common in retired athletes which may negatively impact QOL. However, QOL in retired athletes is poorly understood. This study explores the following questions from the personal perspective of retired cricketers: How do retired cricketers perceive and experience musculoskeletal pain and function in daily life? Are there any psychological attributes that might enhance or hinder retired cricketers’ QOL?DesignA qualitative study using semistructured interviews, which were subject to inductive, thematic analysis. A data-driven, iterative approach to data coding was employed.SettingAll participants had lived and played professional cricket in the UK and were living in the UK or abroad at the time of interview.ParticipantsEighteen male participants, aged a mean 57±11 (range 34–77) years had played professional cricket for a mean 12±7 seasons and had been retired from professional cricket on average 23±9 years.ResultsFifteen participants reported pain or joint difficulties and all but one was satisfied with their QOL. Most retired cricketers reflected on experiences during their cricket career that may be associated with the psychological attributes that these individuals shared, including resilience and a positive attitude. Additional attributes included a high sense of body awareness, an ability to self-manage pain and adapt lifestyle choices to accommodate physical limitations. Participants felt fortunate and proud to have played professional cricket, which may have further contributed to the high QOL in this group of retired cricketers.ConclusionsMost retired cricketers in this study were living with pain or joint difficulties. Despite this, all but one was satisfied or very satisfied with their QOL. This may be partly explained by the positive psychological attributes that these retired cricketers shared.
Five-level emergency triage systems: variation in assessment of validity
Authors: Kuriyama Akira , Urushidani Seigo , Nakayama Takeo 
Published: July 2017

IntroductionTriage systems are scales developed to rate the degree of urgency among patients who arrive at EDs. A number of different scales are in use; however, the way in which they have been validated is inconsistent. Also, it is difficult to define a surrogate that accurately predicts urgency. This systematic review described reference standards and measures used in previous validation studies of five-level triage systems.MethodsWe searched PubMed, EMBASE and CINAHL to identify studies that had assessed the validity of five-level triage systems and described the reference standards and measures applied in these studies. Studies were divided into those using criterion validity (reference standards developed by expert panels or triage systems already in use) and those using construct validity (prognosis, costs and resource use).ResultsA total of 57 studies examined criterion and construct validity of 14 five-level triage systems. Criterion validity was examined by evaluating (1) agreement between the assigned degree of urgency with objective standard criteria (12 studies), (2) overtriage and undertriage (9 studies) and (3) sensitivity and specificity of triage systems (7 studies). Construct validity was examined by looking at (4) the associations between the assigned degree of urgency and measures gauged in EDs (48 studies) and (5) the associations between the assigned degree of urgency and measures gauged after hospitalisation (13 studies). Particularly, among 46 validation studies of the most commonly used triages (Canadian Triage and Acuity Scale, Emergency Severity Index and Manchester Triage System), 13 and 39 studies examined criterion and construct validity, respectively.ConclusionPrevious studies applied various reference standards and measures to validate five-level triage systems. They either created their own reference standard or used a combination of severity/resource measures.
Validation of the Singapore nomogram for outcome prediction in breast phyllodes tumours in a large patient cohort
Authors: Chng Tze Wei , Gudi Mihir , Lim Swee Ho , Li HuiHua , Tan Puay Hoon 
Published: July 2017

AimsTo validate the Singapore nomogram for outcome prediction in breast phyllodes tumours in a large cohort of Singaporean patients, as previous validation studies were conducted on small numbers of patients. We also investigate the association of fibroadenomas and phyllodes tumours within a subset of our cohort.MethodsHistological parameters, surgical margin status and clinical follow-up data of 259 women diagnosed with phyllodes tumours were analysed. Patients with concurrent malignant or premalignant disease were excluded from the validation to minimise confounding influences. Biostatistics modelling was performed, and the concordance between predicted and observed survivals was calculated. The association between fibroadenomas and phyllodes tumours was quantified in a subset of the women.ResultsPhyllodes tumours with higher number of mitoses, stromal overgrowth and positive surgical margins were found to be associated with greater risk of clinical recurrence. Patients with a higher nomogram score had a significantly higher risk of developing relapse. Forty out of 78 (51.3%) of the subset of phyllodes cases reviewed showed either fibroadenoma-like areas within the phyllodes tumours or concurrent fibroadenomas in the ipsilateral or contralateral breast.ConclusionsThe Singapore nomogram is useful in predicting outcome in breast phyllodes tumours when applied to a large cohort of Singaporean women.
Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats
Authors: McMillin Matthew , DeMorrow Sharon , Glaser Shannon , Venter Julie , Kyritsi Konstantina , Zhou Tianhao , Grant Stephanie , Giang Thao , Greene John F. , Wu Nan , Jefferson Brandi , Meng Fanyin , Alpini Gianfranco 
Published: July 2017

Melatonin is a hormone produced by the pineal gland with increased circulating levels shown to inhibit biliary hyperplasia and fibrosis during cholestatic liver injury. Melatonin also has the capability to suppress the release of hypothalamic gonadotropin-releasing hormone (GnRH), a hormone that promotes cholangiocyte proliferation when serum levels are elevated. However, the interplay and contribution of neural melatonin and GnRH to cholangiocyte proliferation and fibrosis in bile duct-ligated (BDL) rats have not been investigated. To test this, cranial levels of melatonin were increased by implanting osmotic minipumps that performed an intracerebroventricular (ICV) infusion of melatonin or saline for 7 days starting at the time of BDL. Hypothalamic GnRH mRNA and cholangiocyte secretion of GnRH and melatonin were assessed. Cholangiocyte proliferation and fibrosis were measured. Primary human hepatic stellate cells (HSCs) were treated with cholangiocyte supernatants, GnRH, or the GnRH receptor antagonist cetrorelix acetate, and cell proliferation and fibrosis gene expression were assessed. Melatonin infusion reduced hypothalamic GnRH mRNA expression and led to decreased GnRH and increased melatonin secretion from cholangiocytes. Infusion of melatonin was found to reduce hepatic injury, cholangiocyte proliferation, and fibrosis during BDL-induced liver injury. HSCs supplemented with BDL cholangiocyte supernatant had increased proliferation, and this increase was reversed when HSCs were supplemented with supernatants from melatonin-infused rats. GnRH stimulated fibrosis gene expression in HSCs, and this was reversed by cetrorelix acetate cotreatment. Increasing bioavailability of melatonin in the brain may improve outcomes during cholestatic liver disease.NEW & NOTEWORTHY We have previously demonstrated that GnRH is expressed in cholangiocytes and promotes their proliferation during cholestasis. In addition, dark therapy, which increases melatonin, reduced cholangiocyte proliferation and fibrosis during cholestasis. This study expands these findings by investigating neural GnRH regulation by melatonin during BDL-induced cholestasis by infusing melatonin into the brain. Melatonin infusion reduced cholangiocyte proliferation and fibrosis, and these effects are due to GNRH receptor 1-dependent paracrine signaling between cholangiocytes and hepatic stellate cells.