bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Relationship Quality on Couples With an Incarcerated Partner With Co-Occurring Mental Health and Substance Use Issues
Authors: Tadros Eman , Le Anh-Khoi Nguyen , Gregorash Alexis 
Published: September 2024

Objective: In 2020, approximately 1.7 million people were incarcerated in the United States, with nearly half of the general population being related to, or romantically involved with, an incarcerated individual. Over 70% of these incarcerated individuals met the criteria for a co-occurring mental health and substance use diagnoses. Individuals with co-occurring disorders often experience high rates of recidivism, which negatively impacts their non-incarcerated partners. This study aimed to examine the impact of incarcerated individuals with co-occurring ADHD and depression on their relationship quality, focusing on the roles of substance use, substance use treatment, and self-efficacy. Methods: The study analyzed the effects of substance use, substance use treatment, and self-efficacy on the relationship quality of couples where one partner was incarcerated and diagnosed with co-occurring ADHD and depression. The direct and indirect influences of these factors on relationship quality were assessed. Results: The findings indicated that higher levels of substance use and depressive symptoms, along with lower levels of self-efficacy and substance use treatment, were associated with lower relationship quality. ADHD indirectly affected relationship quality via substance use (β = −.015, 95% CI [−0.023, −0.008]) and self-efficacy (β = −.027, 95% CI [−0.039, −0.016]). Depression had both direct effects on relationship quality (β = −.180, 95% CI [−0.224, −0.138]) and indirect effects via substance use (β = −.023, 95% CI [−0.033, −0.015]), self-efficacy (β = −.040, 95% CI [−0.056, −0.025]), and through substance use and substance treatment (β = −.002, 95% CI [0.001, 0.005]). Conclusion: These findings highlight the need for further research to explore combined substance use and mental health treatment programs. Such interventions could potentially reduce recidivism rates, and promote the quality and maintenance of relationships among incarcerated individuals and their partners.
Sustainable approach to raw clays for ceramic and refractory applications: insights from updated traditional ternary diagrams
Authors: Vasić Milica V. , Muñoz Velasco Pedro , Mijatović Nevenka , Radormirović Milena , Radojević Zagorka 
Published: September 2024

AbstractThe study analysed 93 samples from four Serbian clay deposits to determine their suitability for ceramics production. The samples were mainly composed of illite and kaolinite. Ternary diagrams were used to classify the samples and evaluate their applicability. Winkler's diagrams, ternary graphs and mineralogical compositions were analysed. The results showed a broader area in these graphs than previously determined for structural ceramics, as well as the potential of these clays for ceramic production. The study used dry-milled, hydraulically semi-dry, pressed and fired samples to assess water absorption and flexural strength and statistical analysis to determine the key parameters influencing final product quality, including that of refractory, wall and floor tiles. This paper evaluates the raw clay materials’ applicability in ceramic production, promoting sustainable use through rapid initial tests, energy savings through dry milling and ecologically sound principles through resource-efficient evaluation.
Peripheral human red blood cell development in human immune system mouse model with heme oxygenase-1 deficiency
Authors: Patel Aditi Khatri , Trageser Kyle , Kim Hyunjin , Lim Weikeat , Adler Christina , Porter Brace , Ni Min , Wei Yi , Atwal Gurinder S. , Bigdelou Parnian , Kulshreshtha Vikas , Ajithdoss Dharani , Zhong Jun , Tu Naxin , Macdonald Lynn , Murphy Andrew , Frleta Davor 
Published: September 2024

Abstract
A challenge for human immune system (HIS) mouse models has been the lack of human red blood cell (hRBC) survival after engraftment of these immune-deficient mice with human CD34+ hematopoietic stem cells (HSCs). This limits the use of HIS models for preclinical testing of targets directed at hRBC-related diseases. Although human white blood cells can develop in the peripheral blood of mice engrafted with human HSCs, peripheral hRBCs are quickly phagocytosed by murine macrophages upon egress from the bone marrow. Genetic ablation of murine myeloid cells results in severe pathology in resulting mice, rendering such an approach to increase hRBC survival in HIS mice impractical. Heme oxygenase-1 (HMOX-1)–deficient mice have reduced macrophages due to toxic buildup of intracellular heme upon engulfment of RBCs, but do not have an overall loss of myeloid cells. We took advantage of this observation and generated HMOX-1–/– mice on a humanized M-CSF/SIRPα/CD47 Rag2–/– IL-2Rγ–/– background. These mice have reduced murine macrophages but comparable levels of murine myeloid cells to HMOX-1+/+ control mice in the same background. Injected hRBCs survive longer in HMOX-1–/– mice than in HMOX-1+/+ controls. Additionally, upon human HSC engraftment, hRBCs can be observed in the peripheral blood of HMOX-1–/– humanized M-CSF/SIRPα/CD47 Rag2–/– IL-2Rγ–/– mice, and hRBC levels can be increased by treatment with human erythropoietin. Given that hRBC are present in the peripheral blood of engrafted HMOX-1–/– mice, these mice have the potential to be used for hematologic disease modeling, and for testing therapeutic treatments for hRBC diseases in vivo.
Psychological burden and depressive symptoms in caregivers of hemato-oncological patients: the role of medical visits
Authors: Abed Al Wahad Ali , Elran-Barak Roni , Furer Marina , Abu Kamir Gihan , Horowitz Netanel A. 
Published: September 2024

Abstract
Informal caregivers of patients with cancer are known to experience extensive burdens, whereas this issue remains unresolved in the setting of hematological malignancies. Yet, these diseases are characterized by a prolonged course, numerous relapses, and implementation of multiline therapy, administered in outpatient facilities. This study aimed to assess the factors contributing to burden and depressive symptoms in informal caregivers of patients with hematological malignancies, while concentrating on the role of medical visits. The study population comprised patients and their caregivers, recruited at the Rambam Hematology Ambulatory Unit. Participants completed validated questionnaires, including the Center for Epidemiologic Studies Depression Scale and the Zarit Caregiver Burden Interview. The cohort (n = 185) included 115 patients (average age, 62.8 ± 14.5 years; 54 males) and 70 caregivers. Among caregivers, 80% reported high psychological burden, and 50% reported significant depressive symptoms. The burden was higher if caregivers were females and if patients were less educated, less healthy, and more depressed. The caregiver burden and depressive symptoms were significantly linked, and the medical visit frequency predicted the level of both. The caregiver burden fully mediated the link between the independent variables of self-rated health and medical visits and the dependent variable of caregiver depressive symptoms. Informal caregivers of ambulatory patients with hemato-oncological malignancies experience high levels of psychological burden and depressive symptoms. This is partly attributed to the medical visit frequency. Hence, a decrease in the number and length of such visits via the implementation of advanced technology could essentially reduce burden and depressive symptoms of caregivers, without compromising patient outcomes.
Measurable residual disease monitoring in AML with FLT3-ITD treated with intensive chemotherapy plus midostaurin
Authors: Rücker Frank G. , Bullinger Lars , Cocciardi Sibylle , Skambraks Sabrina , Luck Tamara J. , Weber Daniela , Krzykalla Julia , Pozek Ema , Schneider Isabelle , Corbacioglu Andrea , Gaidzik Verena I. , Meid Annika , Aicher Sophia , Stegelmann Frank , Schrade Anika , Theis Frauke , Fiedler Walter , Salih Helmut R. , Wulf Gerald , Salwender Hans , Schroeder Thomas , Götze Katharina S. , Kühn Michael W. M. , Lübbert Michael , Schlenk Richard F. , Benner Axel , Thol Felicitas , Heuser Michael , Ganser Arnold , Döhner Hartmut , Döhner Konstanze 
Published: September 2024

Abstract
Measurable residual disease (MRD) monitoring in acute myeloid leukemia (AML) with an FLT3 internal tandem duplication (FLT3-ITDpos) has been hampered by the broad heterogeneity of ITD mutations. Using our recently developed FLT3-ITD paired-end next-generation sequencing (NGS)–based MRD assay (limit of detection 10−4 to 10−5), we evaluated the prognostic impact of MRD at different time points in 157 patients with FLT3-ITDpos AML who were enrolled in the German-Austrian Acute Myeloid Leukemia Study Group 16-10 trial and who were treated with a combination of intensive chemotherapy and midostaurin, followed by midostaurin maintenance. MRD negativity (MRDneg) after 2 cycles of chemotherapy (Cy2), which was observed in 111 of 142 (78%) patients, was predictive of superior 4-year rates of cumulative incidence of relapse (CIR) (4y-CIR; 26% vs 46%; P = .001) and overall survival (OS) (4y-OS; 70% vs 44%; P = .012). This survival advantage was also seen among patients who underwent allogeneic hematopoietic-cell transplantation during first complete remission (4y-CIR, 14% vs 39%; P = .001; 4y-OS, 71% vs 49%; P = .029). Multivariate models for CIR and OS after Cy2 revealed FLT3-ITD MRDneg as the only consistent favorable variable for CIR (hazard ratio [HR], 0.29; P = .006) and OS (HR, 0.39; P = .018). During follow-up, conversion from MRDneg to MRD positivity (MRDpos) was a strong, independent factor for inferior CIR (HR, 16.64; P &lt; .001) and OS (HR, 4.05; P &lt; .001). NGS-based FLT3-ITD MRD monitoring identifies patients at high risk for relapse and death following treatment with intensive chemotherapy and midostaurin. Using NGS-based technology.
Association between rare, genetic variants linked to autism and ultrasonography fetal anomalies in children with autism spectrum disorder
Authors: Regev Ohad , Shil Apurba , Bronshtein Tal , Hadar Amnon , Meiri Gal , Zigdon Dikla , Michaelovski Analya , Hershkovitz Reli , Menashe Idan 
Published: September 2024

Abstract
Background
Recent evidence suggests that certain fetal anomalies detected upon prenatal ultrasound screenings are associated with autism spectrum disorder (ASD). In this cross-sectional study, we aimed to identify genetic variants associated with fetal ultrasound anomalies (UFAs) in children with ASD.

Methods
The study included all children with ASD who are registered in the database of the Azrieli National Center of Autism and Neurodevelopment and for whom both prenatal ultrasound and whole exome sequencing (WES) data were available. We applied our in-house integrative bioinformatics pipeline, AutScore, to these WES data to prioritize rare, gene-disrupting variants (GDVs) probably contributing to ASD susceptibily. Univariate statistics and multivariable regression were used to assess the associations between UFAs and GDVs identified in these children.

Results
The study sample comprised 126 children, of whom 43 (34.1%) had at least one UFA detected in the prenatal ultrasound scan. A total of 87 candidate ASD genetic variants were detected in 60 children, with 24 (40%) children carrying multiple variants. Children with UFAs were more likely to have loss-of-function (LoF) mutations (aOR = 2.55, 95%CI: 1.13–5.80). This association was particularly noticeable when children with structural anomalies or children with UFAs in their head and brain scans were compared to children without UFAs (any mutation: aOR = 8.28, 95%CI: 2.29–30.01; LoF: aOR = 5.72, 95%CI: 2.08–15.71 and any mutation: aOR = 6.39, 95%CI: 1.34–30.47; LoF: aOR = 4.50, 95%CI: 1.32–15.35, respectively). GDVs associated with UFAs were enriched in genes highly expressed across all tissues (aOR = 2.76, 95%CI: 1.14–6.68). There was a weak, but significant, correlation between the number of mutations and the number of abnormalities detected in the same children (r = 0.21, P = 0.016).

Conclusions
The results provide valuable insights into the potential genetic basis of prenatal organogenesis abnormalities associated with ASD and shed light on the complex interplay between genetic factors and fetal development.
Biomarker discovery in progressive supranuclear palsy from human cerebrospinal fluid
Authors: Jang Yura , Oh Sungtaek , Hall Anna J. , Zhang Zhen , Tropea Thomas F. , Chen-Plotkin Alice , Rosenthal Liana S. , Dawson Ted M. , Na Chan Hyun , Pantelyat Alexander Y. 
Published: September 2024

Abstract
Background
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder often misdiagnosed as Parkinson’s Disease (PD) due to shared symptoms. PSP is characterized by the accumulation of tau protein in specific brain regions, leading to loss of balance, gaze impairment, and dementia. Diagnosing PSP is challenging, and there is a significant demand for reliable biomarkers. Existing biomarkers, including tau protein and neurofilament light chain (NfL) levels in cerebrospinal fluid (CSF), show inconsistencies in distinguishing PSP from other neurodegenerative disorders. Therefore, the development of new biomarkers for PSP is imperative.

Methods
We conducted an extensive proteome analysis of CSF samples from 40 PSP patients, 40 PD patients, and 40 healthy controls (HC) using tandem mass tag-based quantification. Mass spectrometry analysis of 120 CSF samples was performed across 13 batches of 11-plex TMT experiments, with data normalization to reduce batch effects. Pathway, interactome, cell-type-specific enrichment, and bootstrap receiver operating characteristic analyses were performed to identify key candidate biomarkers.

Results
We identified a total of 3,653 unique proteins. Our analysis revealed 190, 152, and 247 differentially expressed proteins in comparisons of PSP vs. HC, PSP vs. PD, and PSP vs. both PD and HC, respectively. Gene set enrichment and interactome analysis of the differentially expressed proteins in PSP CSF showed their involvement in cell adhesion, cholesterol metabolism, and glycan biosynthesis. Cell-type enrichment analysis indicated a predominance of neuronally-derived proteins among the differentially expressed proteins. The potential biomarker classification performance demonstrated that ATP6AP2 (reduced in PSP) had the highest AUC (0.922), followed by NEFM, EFEMP2, LAMP2, CHST12, FAT2, B4GALT1, LCAT, CBLN3, FSTL5, ATP6AP1, and GGH.

Conclusion
Biomarker candidate proteins ATP6AP2, NEFM, and CHI3L1 were identified as key differentiators of PSP from the other groups. This study represents the first large-scale use of mass spectrometry-based proteome analysis to identify cerebrospinal fluid (CSF) biomarkers specific to progressive supranuclear palsy (PSP) that can differentiate it from Parkinson’s disease (PD) and healthy controls. Our findings lay a crucial foundation for the development and validation of reliable biomarkers, which will enhance diagnostic accuracy and facilitate early detection of PSP.
Bilateral purtscher-like retinopathy associated with DRESS syndrome: a case report
Authors: Yuan Langxuan , Li Yuchen , Zhang Hanze , Hou Yucen , Kang Qianyan , Lei Jianqin 
Published: September 2024

Abstract
Background
To report a case of Bilateral Purtscher-like retinopathy associated with DRESS syndrome managed with ocular and systemic treatments.

Case presentation
A 29-year-old healthy female developed multi-organ (cutaneous, hematologic, renal and hepatic) disfunction and profound vision loss 1 month after Human papillomavirus vaccine injection. At the first presentation, her visual acuity was counting fingers in both eyes. Fundus exam showed remarkable cotton-wool spots, retinal hemorrhages and macular edema. She was diagnosed DRESS syndrome and Purtscher-like retinopathy and treated with intravitreal injection of ranibizumab, systemic steroids anticoagulants, and plasma exchange. The patient finally recovered from this life-threatening condition but left with permanent visual damage.

Conclusion
Purtscher-like retinopathy could be complicated by DRESS syndrome which is usually considered a type IV hypersensitivity reaction.
Caregivers’ burden of care during emergency department care transitions among older adults: a mixed methods cohort study
Authors: Germain Nathalie , Jémus-Gonzalez Estephanie , Couture Vanessa , Côté Émilie , Morin Michèle , Toulouse-Fournier Annie , Bert Laetitia , Giguère Raphaëlle , Sinha Samir , Sourial Nadia , Chartier Lucas B. , Witteman Holly O. , Légaré France , Samb Rawane , Turcotte Stéphane , Chandavong Sam , Abrougui Lyna , Robitaille Joanie , Archambault Patrick M. ,   on behalf of the Network of Canadian Emergency Researchers
Published: September 2024

Abstract
Objective
Improving care transitions for older adults can reduce emergency department (ED) revisits, and the strain placed upon caregivers. We analyzed whether caregivers felt a change in burden following a care transition, and what may be improved to reduce it.

Methods
This mixed-methods observational study nested within LEARNING WISDOM included caregivers of older patients who experienced an ED care transition. Burden was collected with the brief Zarit Burden Interview (ZBI-12), and caregivers also commented on the care transition. A qualitative coding scheme of patient care transitions was created to reflect themes important to caregivers. Comments were randomly analyzed until saturation and themes were extracted from the data. We followed both the SRQR and STROBE checklists.

Results
Comments from 581 caregivers (mean age (SD) 64.5 (12.3), 68% women) caring for patients (mean age (SD) 77.2 (7.54), 48% women) were analyzed. Caregivers overwhelmingly reported dissatisfaction and unmet service expectations, particularly with home care and domestic help. Communication and follow-up from the ED emerged as an area for improvement. Caregivers who reported an increased level of burden following a patient’s care transition had significantly higher ZBI scores than caregivers who self-reported stable burden levels.

Conclusion
Caregivers with increasing, stable, and improved levels of subjective burden all reported areas for improvement in the care transition process. Themes centering on the capacity to live at home and inadequate communication were most frequently mentioned and may represent serious challenges to caregivers. Addressing these challenges could improve both caregiver burden and ED care transitions.
Burden of metabolic syndrome in the global adult HIV-infected population: a systematic review and meta-analysis
Authors: Trachunthong Deondara , Tipayamongkholgul Mathuros , Chumseng Suchintana , Darasawang Worrayot , Bundhamcharoen Kanitta 
Published: September 2024

Abstract
Background
Metabolic syndrome (MetS) elevates the risk of heart disease and stroke. In recent decades, the escalating prevalence of MetS among people living with HIV/AIDS (PLWHA) has garnered global attention. Despite MetS development being associated with both traditional and HIV-related factors, evidence from prior studies has shown variability across geographical regions. This study aimed to conduct a systematic review and meta-analysis of MetS burdens in adult PLWHA at the regional and global levels, focusing on the common effect size of HIV infection and antiretroviral therapy (ART) on MetS.

Methods
This review followed the PRISMA 2020 guidelines. A comprehensive search and review of original articles related to MetS and HIV published in peer-reviewed journals between January 2000 and December 2023 were conducted. A random effects model was used to calculate the pooled prevalence/incidence of MetS and the common effect size of HIV infection and ART exposure on MetS.

Results
A total of 102 studies from five continents comprising 78,700 HIV-infected participants were included. The overall pooled prevalence of MetS was 25.3%, 25.6% for PLWHA on ART, and 18.5% for those not receiving treatment. The pooled incidence of MetS, calculated from five studies, was 9.19 per 100 person-years. The highest pooled prevalence of MetS was observed in the Americas (30.4%), followed by the Southeast Asia/Western Pacific regions (26.7%). HIV-infected individuals had 1.6 times greater odds of having MetS than non-HIV-infected individuals did (pooled OR = 1.604; 95% CI 1.154–2.230), and ART exposure had 1.5 times greater odds of having MetS than nontreatment had (pooled OR = 1.504; 95% CI 1.217–1.859).

Conclusions
HIV infection and ART exposure contribute significantly to the increased burden of MetS. Regions with a high burden of HIV and MetS should prioritize awareness and integrated care plans for major noncommunicable diseases (NCDs), such as heart disease and stroke. The implementation of integrated care for HIV/AIDS patients and NCDs is essential for addressing the high burden of multimorbidity in PLWHA.

Registration number
INPLASY202290018
Health-related quality of life measured with K-BILD is associated with survival in patients with idiopathic pulmonary fibrosis
Authors: Rautajoki Tuuli , Rantala Heidi A. , Sutinen Eva , Saarto Tiina , Rajala Kaisa , Pesonen Ida , Hollmen Maria , Myllärniemi Marjukka , Lehto Juho T. 
Published: September 2024

Abstract
Background
Health-related quality of life (HRQoL) assessments and estimates of prognosis are needed for comprehensive care and planning of subsequent treatment in patients with idiopathic pulmonary fibrosis (IPF). We investigated HRQoL and its association with survival using a disease-specific tool in patients with IPF.

Methods
The patients were recruited from the real-life FinnishIPF study in 2015. HRQoL was assessed with the King’s Brief Interstitial Lung Disease (K-BILD) questionnaire every six months for 2.5 years. Dyspnoea was assessed with the modified Medical Research Council (mMRC) dyspnoea scale. Survival was registered until 31 December 2022. Patient survival according to the K-BILD total score was evaluated using the Kaplan‒Meier method. The Friedman test was used to compare the K-BILD total scores longitudinally, and the Mann‒Whitney U test was used to compare the mMRC groups. P values < 0.05 were considered statistically significant.

Results
The median K-BILD total score (n = 245) was 51.6. At baseline, patients in the highest HRQoL quartile (K-BILD scores 58.9–100) had a longer median survival time (5.3 years) than did those with scores of 51.7–58.8 (3.1 years), 45.7–51.6 (2.3 years), and 0.0–45.6 (1.8 years). A decrease in the K-BILD total score of ≥ 5 units in the preceding 12 or 24 months showed a trend towards poorer survival, although statistical significance was not reached. Ninety-four patients survived more than 2.5 years and had available K-BILD data at all time points. The K-BILD total score remained higher in patients with a baseline mMRC of 0–1 than in those with a mMRC of 2–4, and the total score decreased only modestly in both groups (median of 3.3 and 4.8 units in patients with mMRC scores of 0–1 and 2–4, respectively).

Conclusions
In IPF, a reduced HRQoL is associated with impaired survival. A K-BILD total score less than approximately 50 units is associated with a median survival of approximately two years. In addition to assessing the treatment needs of patients with IPF using K-BILD, a decreased score may be useful for facilitating advance care planning and transplantation assessment.