bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphine‐Catalyzed Direct δ‐Carbon Addition of Alkynones to Electron‐Deficient Carbonyl‐Group‐Containing Compounds: Preparation of Conjugated Dienes
Authors: Sun Yao‐Liang , Zhang Xiao‐Nan , Wei Yin , Shi Min 
Published: September 2016

AbstractThe formerly unexplored δ‐carbon of alkynones could be activated as a nucleophilic reaction site and trapped by electron‐deficient carbonyl‐group‐containing compounds upon phosphine catalysis, which provided three kinds of δ‐addition and isomerization products in moderate to excellent yields. Plausible mechanisms were proposed on the basis of deuterium‐labeling experiments. Thus, a novel strategy for phosphine‐catalyzed δ‐carbon addition of alkynones to electron‐deficient carbonyl groups was developed, affording the corresponding substituted 3,5‐dien‐2‐one derivatives under mild conditions.
ChemInform Abstract: (Thiolan‐2‐yl)diphenylmethyl Benzyl Ether/N,N′‐Diarylurea Cocatalyzed Asymmetric Aziridination of Cinnamyl Bromide and Aryl Aldimine
Authors: Wang Shang‐Hua , Chein Rong‐Jie 
Published: September 2016

Abstract15 examples
ChemInform Abstract: Asymmetric Hydrogenation of α‐Substituted Acrylic Acids Catalyzed by a Ruthenocenyl Phosphino‐Oxazoline—Ruthenium Complex.
Authors: Li Jing , Shen Jiefeng , Xia Chao , Wang Yanzhao , Liu Delong , Zhang Wanbin 
Published: September 2016

AbstractThe asymmetric hydrogenation protocol affords α‐substituted propanoic acids with enantioselectivities up to 99.9%.
ChemInform Abstract: Enantioselective Borane Reduction of Ketones Catalyzed by Tricyclic 1,3,2‐Oxazaborolidines.
Authors: Kaldun Johannes , Krimalowski Alexander , Breuning Matthias 
Published: September 2016

AbstractNovel tricyclic oxazaborolidines are synthesized in seven steps from methyl Boc‐L‐pyroglutamate and utilized as catalyst in the asymmetric borane reduction of various ketones with excellent enantioselectivities.
ChemInform Abstract: Story of an Age‐Old Reagent: An Electrophilic Chlorination of Arenes and Heterocycles by 1‐Chloro‐1,2‐benziodoxol‐3‐one.
Authors: Wang Mengzhou , Zhang Yanyan , Wang Tao , Wang Chao , Xue Dong , Xiao Jianliang 
Published: September 2016

AbstractThe reaction has a very broad substrate scope and tolerates a range of heterocycles such as pyrrole, indole, thiazole, pyrazole, pyridine, quinoline and pyrimidine derivatives as well as various arenes, which may contain diverse functional groups.
ChemInform Abstract: Highly Mono‐Selective ortho‐Trifluoromethylation of Benzamides via 8‐Aminoquinoline Assisted Cu‐Promoted C—H Activations.
Authors: Hu Liang , Chen Xiang , Gui Qingwen , Tan Ze , Zhu Gangguo 
Published: September 2016

AbstractA trifluoromethylation of benzamides with Togni reagent II provides the corresponding aromatic mono(trifluoromethyl) amides by using a quinolinylamino group as directing group.
ChemInform Abstract: Chan—Evans—Lam Amination of Boronic Acid Pinacol (BPin) Esters: Overcoming the Aryl Amine Problem.
Authors: Vantourout Julien C. , Law Robert P. , Isidro‐Llobet Albert , Atkinson Stephen J. , Watson Allan J. B. 
Published: September 2016

AbstractThe reaction conditions for Chan—Evans—Lam amination of alkyl and aryl amines with aryl boronic acid pinacol esters are revised.
ChemInform Abstract: “On Water” Organocatalyzed [4 + 2] Cycloaddition of Enones and Nitro Dienes for the Enantioselective Synthesis of Densely Substituted Cyclohexanones.
Authors: Vamisetti Ganga B. , Chowdhury Raghunath , Kumar Mukesh , Ghosh Sunil K. 
Published: September 2016

AbstractThe reaction proceeds with high diastereoselectivity and excellent enantioselectivity.
ChemInform Abstract: Transition‐Metal‐Free Synthesis of N‐Aryl Hydroxamic Acids via Insertion of Arynes.
Authors: Zhang Lanlan , Geng Yu , Jin Zhong 
Published: September 2016

AbstractThe scalable title synthesis is successfully performed starting from aryl, hetaryl alkenyl and alkyl amides as well as N‐protected amino acid and peptide derived amides.
ChemInform Abstract: Oxygen‐Promoted Pd/C‐Catalyzed Suzuki—Miyaura Reaction of Potassium Aryltrifluoroborates.
Authors: Liu Chun , Liu Chao , Li Xin‐Min , Gao Zhan‐Ming , Jin Zi‐Lin 
Published: September 2016

AbstractA simple, efficient and ligand‐free protocol for the Suzuki—Miyaura reaction is developed and successfully applied for the synthesis of aryl‐substituted 9‐phenylcarbazole derivatives such as (IIIi) and (IIIj).
ChemInform Abstract: Sequential, One‐Pot Access to Arylated Benzoquinones/Naphthoquinones from Phenols/Naphthols.
Authors: Jiang Jia‐Heng , Boominathan Siva Senthil Kumar , Hu Wan‐Ping , Chen Chung‐Yu , Vandavasi Jaya Kishore , Lin Ying‐Ting , Wang Jeh‐Jeng 
Published: September 2016

AbstractOxidation of 1‐naphthols to naphthoquinones and subsequent TFA‐catalyzed coupling with electron‐rich benzenes and N‐heterocycles results in regioselective C‐H arylation to produce 2‐substituted 1,4‐naphthoquinones.
ChemInform Abstract: Microwave Assisted Aminocatalyzed [3 + 2] Annulation Between α‐Iminonitriles and Succinaldehyde: Synthesis of Pyrrole‐3‐methanols and Related Polycyclic Ring Systems.
Authors: Mir Nisar A. , Choudhary Sachin , Ramaraju Panduga , Singh Deepika , Kumar Indresh 
Published: September 2016

AbstractThe described one‐pot approach proceeds through amino catalyzed direct Mannich reaction‐cyclization‐dehydrocyanation followed by NaBH4 reduction sequence.
ChemInform Abstract: Stereospecific Preparation of γ‐Lactam Derivatives via Ring Expansion of cis and trans β‐Lactam Derivatives: α‐Substituent Effect of β‐Lactam Derivatives.
Authors: Lee Mi‐Ji , Ahn Chuljin 
Published: September 2016

AbstractIn the case of aryl substituents in trans or cis β‐lactam derivatives, only the trans γ‐lactam derivative is obtained, whereas trans or cis β‐lactams with alkyl substituents lead to the corresponding trans or cis γ‐lactam, respectively.
ChemInform Abstract: Lewis Acid and Fluoroalcohol Mediated Nucleophilic Addition to the C2 Position of Indoles.
Authors: Morimoto Naoki , Morioku Kumika , Suzuki Hideyuki , Takeuchi Yasuo , Nishina Yuta 
Published: September 2016

AbstractThe formation of indolium is described allowing for the 2‐selective inter‐ as well as intramolecular highly regioselective nucleophilic addition of electron rich aromatic compounds.
ChemInform Abstract: Facile Syntheses of N‐Heterocyclic Carbene Precursors Through I2‐ or NIS‐Promoted Amidiniumation of N‐Alkenyl Formamidines.
Authors: Li Jing , Jiao Jiajun , Zhang Caiyun , Shi Min , Zhang Jun 
Published: September 2016

AbstractAn oxidative cyclization of N‐alkenyl formamidines leads to the corresponding cyclic formamidinium salts.
ChemInform Abstract: Access to Isoquinolines and Isoquinolin‐3‐ols via Rh(III)‐Catalyzed Coupling/Cyclization Cascade Reaction of Arylimidates and Diazo Compounds.
Authors: Li Xing Guang , Sun Min , Jin Qiao , Liu Kai , Liu Pei Nian 
Published: September 2016

AbstractAn oxidant‐free, Rh(III)‐catalyzed coupling/cyclization cascade reaction yielding isoquinolines via C—H activation is developed.
ChemInform Abstract: TEMPO‐Mediated Aza‐Diels—Alder Reaction: Synthesis of Tetrahydropyridazines Using Ketohydrazones and Olefins.
Authors: Yang Xiu‐Long , Peng Xie‐Xue , Chen Fei , Han Bing 
Published: September 2016

AbstractThe scalable, metal‐free title reaction tolerates aryl, hetaryl and alkylmethyl hydrazones, as well as various acrylates, styrene derivatives and 1,1‐disubstituted alkenes.
ChemInform Abstract: Stereodivergent Silylzincation of α‐Heteroatom‐Substituted Alkynes.
Authors: Fopp Carolin , Romain Elise , Isaac Kevin , Chemla Fabrice , Ferreira Franck , Jackowski Olivier , Oestreich Martin , Perez‐Luna Alejandro 
Published: September 2016

AbstractA catalyst‐free regio‐ and stereoselective addition of Zn‐Si reagents onto nitrogen‐, sulfur‐, oxygen‐ and phosphorus‐substituted terminal alkynes is described.
ChemInform Abstract: Sulfated Glucosides of an Aliphatic Alcohol and Monoterpenes, and Megastigmanes from the Leaves of Meliosma pinnata spp. arnottiana
Authors: Uemura Yuka , Kawakami Susumu , Sugimoto Sachiko , Matsunami Katsuyoshi , Otsuka Hideaki , Shinzato Takakazu 
Published: September 2016

Abstractisolation and structure determination
Preparation of Enantiomerically Pure (S)‐(−)‐1‐(1′‐naphthyl)‐ethanol by the Fungus Alternaria alternata
Authors: Zilbeyaz Kani , Kurbanoglu Esabi Basaran , Kilic Hamdullah 
Published: September 2016

Abstract(S)‐(−)‐1‐(1′‐napthyl)‐ethanol (S‐NE) is an important intermediate for the preparation of mevinic acid analogs, which is used for the treatment of hyperlipidemia. The objectives of the study were to isolate a microorganism that could effectively reduce 1‐acetonaphthone (1‐ACN) to S‐NE, to determine the influence that the physicochemical parameters would have on the reduction by the isolated microorganism, and to attempt large‐scale studies with the microorganism. Over the years fungi have been considered a promising biocatalyst and it has been presumed that many fungal species have not been isolated and therefore the current study focused on possible isolation of these microorganisms. A total of 72 fungal isolates were screened for their ability to reduce 1‐ACN to its corresponding alcohol. The isolate, EBK‐62, identified as Alternaria alternata, was found to be the most successful at reducing the ketone to the corresponding alcohol in the submerged culture. The reaction conditions were systematically optimized for the reducing agent A. alternata EBK‐62, which showed high stereospecificity and good conversion for the reduction. The preparative scale study was carried out in a 2 L bioreactor and a total of 4.9 g of S‐NE in optically pure form (>99% enantiomeric excess) was produced in 48 h. Chirality 28:669–673, 2016. © 2016 Wiley Periodicals, Inc.
Melanin‐concentrating hormone axons, but not orexin or tyrosine hydroxylase axons, innervate the claustrum in the rat: An immunohistochemical study
Authors: Barbier Marie , Houdayer Christophe , Franchi Gabrielle , Poncet Fabrice , Risold Pierre‐Yves 
Published: September 2016

ABSTRACTThe claustrum is a small, elongated nucleus close to the external capsule and deep in the insular cortex. In rodents, this nucleus is characterized by a dense cluster of parvalbumin labeling. The claustrum is connected with the cerebral cortex. It does not project to the brainstem, but brainstem structures can influence this nucleus. To identify some specific projections from the lateral hypothalamus and midbrain, we analyzed the distribution of projections labeled with antibodies against tyrosine hydroxylase (TH), melanin‐concentrating hormone (MCH), and hypocretin (Hcrt) in the region of the claustrum. The claustrum contains a significant projection by MCH axons, whereas it is devoid of TH projections. Unlike TH and MCH axons, Hcrt axons are scattered throughout the region. This observation is discussed mainly with regard to the role of the claustrum in cognitive functions and that of MCH in REM sleep. J. Comp. Neurol. 525:1489–1498, 2017. © 2016 Wiley Periodicals, Inc.
Natural‐Cellulose‐Derived Tin‐Nanoparticle/Carbon‐Nanofiber Composite as Anodic Material in Lithium‐Ion Batteries
Authors: Wang Kun , Wang Mengya , Huang Jianguo 
Published: September 2016

AbstractA series of tin‐nanoparticle/carbon‐nanofiber composites with varied tin content were synthesized by employing natural cellulose (e.g., ordinary laboratory filter paper) as both the structural scaffold and carbon source. The nanocomposites were obtained through hydrogen reduction of nanofibrous tin‐oxide/carbon hybrids that were prepared by a self‐assembly technique based on the surface sol–gel process. The nanocomposite with 16 wt % tin content was composed of fine metallic tin nanocrystallites with sizes of 20–50 nm that were uniformly immobilized on the surface of the cellulose‐derived carbon nanofibers. When employed as an anodic material for lithium‐ion batteries, because of its unique three‐dimensionally hierarchical porous structures and the buffering effect of the carbon matrix, it showed a stable discharge capacity of ca. 430 mAh g−1 after 200 charge/discharge cycles at a current density of 100 mA g−1, which was close to the calculated theoretical capacity of the electrode. In addition, its structural stability upon extensive charge/discharge cycling processes is outstanding.
Detection of Explosive Vapors: The Roles of Exciton and Molecular Diffusion in Real‐Time Sensing
Authors: Ali Mohammad A. , Shoaee Safa , Fan Shengqiang , Burn Paul L. , Gentle Ian R. , Meredith Paul , Shaw Paul E. 
Published: September 2016

AbstractTime‐resolved quartz crystal microbalance with in situ fluorescence measurements are used to monitor the sorption of the nitroaromatic (explosive) vapor, 2,4‐dinitrotoluene (DNT) into a porous pentiptycene‐containing poly(phenyleneethynylene) sensing film. Correlation of the nitroaromatic mass uptake with fluorescence quenching shows that the analyte diffusion follows the Case‐II transport model, a film‐swelling‐limited process, in which a sharp diffusional front propagates at a constant velocity through the film. At a low vapor pressure of DNT of ≈16 ppb, the analyte concentration in the front is sufficiently high to give an average fluorophore–analyte separation of ≈1.5 nm. Hence, a long exciton diffusion length is not required for real‐time sensing in the solid state. Rather the diffusion behavior of the analyte and the strength of the binding interaction between the analyte and the polymer play first‐order roles in the fluorescence quenching process.
How Ions Arrange in Solution: Detailed Insight from NMR Spectroscopy of Paramagnetic Ion Pairs
Authors: Damjanović Marko , Morita Takaumi , Horii Yoji , Katoh Keiichi , Yamashita Masahiro , Enders Markus 
Published: September 2016

AbstractIon pairing between the paramagnetic anion [Tb(obPc)2]− (obPc=2,3,9,10,16,17,23,24‐octabutoxyphthalocyaninato), which has a very large magnetic anisotropy, with various diamagnetic counterions [P(Ph)4]+ (1 a), [As(Ph)4]+ (1 b), bis(triphenylphosphine)iminium ([PPN]+, 1 c) and tetra‐n‐butylammonium ([TBA]+, 1 d) was studied by means of 1H, 13C, 14N, and 31P NMR spectroscopy in solution at various temperatures. The influence of the paramagnetic anion on the NMR spectroscopy properties of the diamagnetic cations allowed a detailed insight into the distances and relative orientations of the paired ions. Isotropic tumbling models for the description of the quaternary cations are inaccurate, particularly for [TBA]+ with its flexible butyl chains. The effects of temperature and concentration were also assessed. The advantage of this technique is that relatively large distances and the orientation between molecules or ions in solution can be studied.
Solid‐Phase Synthesis of Oligodeoxynucleotide Analogs Containing Phosphorodithioate Linkages
Authors: Yang Xianbin 
Published: September 2016

AbstractThe oligodeoxynucleotide phosphorodithioate modification (PS2‐ODN) uses two sulfur atoms to replace two non‐bridging oxygen atoms at an internucleotide phosphordiester backbone linkage. Like a natural phosphodiester ODN backbone linkage, a PS2‐modified backbone linkage is achiral at phosphorus. PS2‐ODNs are highly stable to nucleases and numerous in vitro assays have demonstrated their biological activity. For example, PS2‐ODNs activated RNase H in vitro, strongly inhibited human immunodeficiency virus (HIV) reverse transcriptase, induced B‐cell proliferation and differentiation, and bound to protein targets in the form of PS2‐aptamers (thioaptamers). Thus, the interest in and promise of PS2‐ODNs has spawned a variety of strategies for synthesizing, isolating, and characterizing this compounds. ODN‐thiophosphoramidite monomers are commercially available from either AM Biotechnologies or Glen Research and this unit describes an effective methodology for solid‐phase synthesis, deprotection, and purification of ODNs having PS2 internucleotide linkages. © 2016 by John Wiley & Sons, Inc.
Synthesis of 4′‐Methoxy 2′‐Deoxynucleoside Phosphoramidites for Incorporation into Oligonucleotides
Authors: Petrová Magdalena , Rosenberg Ivan 
Published: September 2016

AbstractThis unit contains detailed synthetic protocols for the preparation of 4′‐methoxy 2′‐deoxynucleoside phosphoramidite monomers for A, G, C, T, and U. First, 3′‐silyl‐protected 2′‐deoxynucleosides (dNs) are converted in two steps to 4′,5′‐enol acetates as the key starting compounds. Next, 4′‐methoxy dNs are prepared by a one‐pot procedure comprising N‐iodosuccinimide‐promoted methoxylation, hydrolysis, and reduction of the formed intermediates. Finally, 3′‐phosphoramidites of 4′‐methoxy dNs are obtained by a routine three‐step procedure. Title phosphoramidite monomers are suitable for the synthesis of oligonucleotides on solid phase according to conventional amidite chemistry. 4′‐Methoxy substitution represents a simple modification of the sugar part of dNs, where β‐D‐erythro epimers preferentially adopt N‐type (C3′‐endo, RNA‐like) conformation. Moreover, it imparts superior chemical stability, nuclease resistance, and excellent hybridization properties to modified 4′‐methoxyoligodeoxynucleotides. The strong tendency toward RNA‐selective hybridization suggests its potential utilization in antisense and/or RNAi technologies. © 2016 by John Wiley & Sons, Inc.
Fluorescence In Situ Hybridization to Maize (Zea mays) Chromosomes
Authors: McCaw Morgan , Graham Nathaniel , Cody Jon , Swyers Nathan , Zhao Changzeng , Birchler James 
Published: September 2016

AbstractFluorescence In Situ Hybridization (FISH) is the annealing of fluorescent DNA probes to their complementary sequences on prepared chromosomes and subsequent visualization with a fluorescent microscope. In maize, FISH is useful for distinguishing each of the ten chromosomes in different accessions (karyotyping), roughly mapping single genes, transposable elements, transgene insertions, and identifying various chromosomal alterations. FISH can also be used to distinguish chromosomes between different Zea species in interspecific hybrids by use of retroelement painting. © 2016 by John Wiley & Sons, Inc.
Synthesis and Pharmacological Evaluation of Indole Derivatives as Deaza Analogues of Potent Human Neutrophil Elastase Inhibitors
Authors: Crocetti Letizia , Schepetkin Igor A. , Ciciani Giovanna , Giovannoni Maria Paola , Guerrini Gabriella , Iacovone Antonella , Khlebnikov Andrei I. , Kirpotina Liliya N. , Quinn Mark T. , Vergelli Claudia 
Published: September 2016

ABSTRACT

Preclinical Research

A number of N‐benzoylindoles were designed and synthesized as deaza analogs of previously reported potent and selective HNE inhibitors with an indazole scaffold. The new compounds containing substituents and functions that were most active in the previous series were active in the micromolar range (the most potent had IC50 = 3.8 μM) or inactive. These results demonstrated the importance of N‐2 in the indazole nucleus. Docking studies performed on several compounds containing the same substituents but with an indole or an indazole scaffold, respectively, highlight interesting aspects concerning the molecule orientation and H‐bonding interactions, which could help to explain the lower activity of this new series. Drug Dev Res, 2016.   © 2016 Wiley Periodicals, Inc.
Diploid male production correlates with genetic diversity in the parasitoid wasp Venturia canescens: a genetic approach with new microsatellite markers
Authors: Collet Marie , Vayssade Chloé , Auguste Alexandra , Mouton Laurence , Desouhant Emmanuel , Malausa Thibaut , Fauvergue Xavier 
Published: September 2016

AbstractSex determination is ruled by haplodiploidy in Hymenoptera, with haploid males arising from unfertilized eggs and diploid females from fertilized eggs. However, diploid males with null fitness are produced under complementary sex determination (CSD), when individuals are homozygous for this locus. Diploid males are expected to be more frequent in genetically eroded populations (such as islands and captive populations), as genetic diversity at the csd locus should be low. However, only a few studies have focused on the relation between population size, genetic diversity, and the proportion of diploid males in the field. Here, we developed new microsatellite markers in order to assess and compare genetic diversity and diploid male proportion (DMP) in populations from three distinct habitat types – mainland, island, or captive –, in the parasitoid wasp Venturia canescens. Eroded genetic diversity and higher DMP were found in island and captive populations, and habitat type had large effect on genetic diversity. Therefore, DMP reflects the decreasing genetic diversity in small and isolated populations. Thus, Hymenopteran populations can be at high extinction risk due to habitat destruction or fragmentation.
Heterotrophy mitigates the response of the temperate coral Oculina arbuscula to temperature stress
Authors: Aichelman Hannah E. , Townsend Joseph E. , Courtney Travis A. , Baumann Justin H. , Davies Sarah W. , Castillo Karl D. 
Published: September 2016

AbstractAnthropogenic increases in atmospheric carbon dioxide concentration have caused global average sea surface temperature (SST) to increase by approximately 0.11°C per decade between 1971 and 2010 – a trend that is projected to continue through the 21st century. A multitude of research studies have demonstrated that increased SSTs compromise the coral holobiont (cnidarian host and its symbiotic algae) by reducing both host calcification and symbiont density, among other variables. However, we still do not fully understand the role of heterotrophy in the response of the coral holobiont to elevated temperature, particularly for temperate corals. Here, we conducted a pair of independent experiments to investigate the influence of heterotrophy on the response of the temperate scleractinian coral Oculina arbuscula to thermal stress. Colonies of O. arbuscula from Radio Island, North Carolina, were exposed to four feeding treatments (zero, low, moderate, and high concentrations of newly hatched Artemia sp. nauplii) across two independent temperature experiments (average annual SST (20°C) and average summer temperature (28°C) for the interval 2005–2012) to quantify the effects of heterotrophy on coral skeletal growth and symbiont density. Results suggest that heterotrophy mitigated both reduced skeletal growth and decreased symbiont density observed for unfed corals reared at 28°C. This study highlights the importance of heterotrophy in maintaining coral holobiont fitness under thermal stress and has important implications for the interpretation of coral response to climate change.