bluuebunny/crossref_metadata_2025_split huggingface dataset:
Size, growth, and density data for shallow‐water sea urchins from Mexico to the Aleutian Islands, Alaska, 1956–2016
Authors: Ebert Thomas A. , Barr Louis M. , Bodkin James L. , Burcham Dirk , Bureau Dominique , Carson Henry S. , L. Caruso Nancy , Caselle Jennifer E. , Claisse Jeremy T. , Clemente Sabrina , Davis Kathryn , Detwiler Paul M. , Dixon John D. , Duggins David O. , Engle John M. , Estes James A. , Groth Scott D. , Grupe Benjamin M. , Halmay Peter , Hebert Kyle P. , Hernández José C. , Jurgens Laura J. , Kalvass Peter E. , Kenner Michael C. , Konar Brenda , Kushner David J. , Lee Lynn C. , Leighton David L. , Montaño‐Moctezuma Gabriela , Eric Munk J. , Olguin Irma , Palleiro Julio S. , Parker David O. , Pearse John S. , Pondella Daniel J. , Rogers‐Bennett Laura , Schroeter Stephen C. , Shelton Andrew Olaf , Sonnenholzner Jorge , Taniguchi Ian K. , VanBlaricom Glenn R. , Watson Jane C. , Weitzman Benjamin P. , Williams Jonathan P. , Yakimishyn Jennifer , Zhang Zane 
Published: December 2017

AbstractSize, growth, and density have been studied for North American Pacific coast sea urchins Strongylocentrotus purpuratus, S. droebachiensis, S. polyacanthus, Mesocentrotus (Strongylocentrotus) franciscanus, Lytechinus pictus, Centrostephanus coronatus, and Arbacia stellata by various workers at diverse sites and for varying lengths of time from 1956 to present. Numerous peer‐reviewed publications have used some of these data but some data have appeared only in graduate theses or the gray literature. There also are data that have never appeared outside original data sheets. Motivation for studies has included fisheries management and environmental monitoring of sewer and power plant outfalls as well as changes associated with disease epidemics. Studies also have focused on kelp restoration, community effects of sea otters, basic sea urchin biology, and monitoring. The data sets presented here are a historical record of size, density, and growth for a common group of marine invertebrates in intertidal and nearshore environments that can be used to test hypotheses concerning future changes associated with fisheries practices, shifts of predator distributions, climate and ecosystem changes, and ocean acidification along the Pacific Coast of North America and islands of the north Pacific. No copyright restrictions apply. Please credit this paper when using the data.
Predator‐prey interactions cause apparent competition between marine zooplankton groups
Authors: Stige Leif Christian , Kvile Kristina Ø. , Bogstad Bjarte , Langangen Øystein 
Published: December 2017

AbstractPredator‐mediated apparent competition is an indirect negative interaction between two prey species mediated by a shared predator. Quantifying such indirect ecosystem effects is methodologically challenging but important for understanding ecosystem functioning. Still, there are few examples of apparent competition from pelagic marine environments. Using state‐space statistical modeling, we here provide evidence for apparent competition between two dominant zooplankton groups in a large marine ecosystem, i.e., krill and copepods in the Barents Sea. This effect is mediated by a positive association between krill biomass and survival of the main planktivorous fish in the Barents Sea, capelin Mallotus villosus, and a negative association between capelin and copepod biomasses. The biomass of Atlantic krill species is expected to increase in the Barents Sea due to ongoing climate change, thereby potentially negatively affecting copepods through apparent competition. By demonstrating and quantifying apparent competition in a large marine ecosystem, our study paves the way for more realistic projections of indirect ecosystem effects of climate change and harvesting.
Collaborative Governance for Climate Change Adaptation: Mapping citizen–municipality interactions
Authors: Brink Ebba , Wamsler Christine 
Published: December 2017

AbstractIncreasing climate change impacts are a major threat to sustainable urban development, and challenge current governance structures, including actors' responsibilities for dealing with climate variability and extremes. The need for distributed risk governance and citizen engagement is increasingly recognised; however, few empirical studies systematically assess interactions between citizens and municipalities in climate risk management and adaptation. Here, we develop an explorative framework, applied to three Swedish municipalities, to map existing ‘adaptation interactions’ and analyse how responsibilities for climate adaptation manifest and are (re)negotiated. The results show that adaptation planners rarely consider collaborations with citizens, despite positive adaptation outcomes from related local processes. Structures and mechanisms for systematic monitoring and learning are also lacking. We argue that fostering collaborations with citizens – to support long‐term adaptation and reduce the adaptation burden of those most at risk – requires consideration of four strategic issues: proactive engagement; equity and ‘responsibilisation’; nature‐based approaches; and systematic adaptation mainstreaming. Finally, we discuss how our analytical framework can contribute to further theorising municipalities' engagement with citizens on climate risk. © 2017 The Authors. Environmental Policy and Governance published by ERP Environment and John Wiley & Sons Ltd
A biopsychosocial understanding of lower back pain: Content analysis of online information
Authors: Black N.M. , Sullivan S.J. , Mani R. 
Published: December 2017

AbstractObjectives(1) To develop a checklist to assess the representation of biopsychosocial lower back pain (LBP) online information; (2) to analyse publicly accessed online LBP information from a Google search for the degree that psychosocial contributors are described alongside the traditional biomedical approach to explaining LBP; (3) whether websites use information on pain biology to educate on LBP; (4) any inaccurate or false information regarding the mechanisms of LBP and; (5) the amount of websites certified by established benchmarks for quality health information.Materials and methodsAn online search was conducted using the Google search engines of six major English‐speaking countries. Website content was analysed using three checklists developed for the purpose of this study – Biopsychosocial information categorisation checklist and scoring criteria; pain biology information checklist; and the inaccurate information checklist. Website quality was identified by the presence of an Health on the Net certification (HONcode).ResultsOf the fifteen websites analysed, the content of 26.7% of websites was classified as ‘biomedical’, 60% ‘limited psychosocial’ and 13.3% ‘reasonable psychosocial’; 20% included information on pain biology; 46.7% inaccurately implied pain to be equal to tissue damage and 46.7% implied pathways specific to pain transmission; 40% were HONcode certified.ConclusionOnline LBP information retrieved through a Google search has limited to no integration of psychosocial or pain biology information. The focus on tissue pathology is further supported by the inaccurate descriptions of pain as equal to tissue damage and as an input to the central nervous system (CNS). Online LBP information needs to be guided by criteria more sensitive to the psychosocial contributors to pain.SignificanceThe online LBP information retrieved from a Google search needs to be guided by information more sensitive to the psychosocial contributors to pain and disability. This study also highlights the presence of inaccurate information that implied pain as a measure of tissue damage or as an input to the nervous system.
Synthesis and Application of Polypyrrole/Fe3O4 Nanosize Magnetic Adsorbent for Efficient Separation of Hg2+ from Aqueous Solution
Authors: Falahian Zohreh , Torki Firoozeh , Faghihian Hossein 
Published: December 2017

AbstractIn order to prepare the magnetic adsorbent, polymerization of pyrrole is performed in a mixture containing Fe3O4 and FeCl3. FTIR, XRD, SEM, EDAX, BET and VSM techniques are employed to characterize the synthesized adsorbent. The results indicate that a homogeneous film of polypyrrole is formed on the surface of magnetic material. The synthesized adsorbent uptakes 173.16 mg g−1 of Hg2+ from aqueous solution, which is superior to the previously reported results for a similar adsorbent. Magnetic performance of the adsorbent is sufficient to separate the used adsorbent from the solution by use of a magnetic bar placed outside of the vessel. Langmuir, Freundlich, Temkin, Redlich–Peterson, and Sips isotherm models are employed to evaluate the experimental adsorption data. The kinetic models are studied and the experimental data are described by the pseudo‐second‐order kinetic model. The calculated thermodynamic parameter shows that the sorption process is endothermic and spontaneous. Regeneration of the used adsorbent indicates that more than 90% of the initial capacity remains after regeneration.
Semantic Network Analysis Reveals Opposing Online Representations of the Search Term “GMO”
Authors: Jiang Ke , Anderton Brittany N. , Ronald Pamela C. , Barnett George A. 
Published: December 2017

AbstractMaking sound food and agriculture decisions is important for global society and the environment. Experts tend to view crop genetic engineering, a technology that can improve yields and minimize impacts on the environment, more favorably than the public. Because there is a causal relationship between public opinion and public policy, it is important to understand how opinions about genetically engineered (GE) crops are influenced. The public increasingly seeks science information on the Internet. Here, semantic network analysis is performed to characterize the presentation of the term “GMO (genetically modified organism),” a proxy for food developed from GE crops, on the web. Texts from three sources are analyzed: U.S. federal websites, top pages from a Google search, and online news titles. We found that the framing and sentiment (positive, neutral, or negative attitudes) of “GMO” varies across these sources. It is described how differences in the portrayal of GE food by each source might affect public opinion. A current understanding of the types of information individuals may encounter online can provide insight into public opinion toward GE food. In turn, this knowledge can guide teaching and communication efforts by the scientific community to promote informed decision‐making about agricultural biotechnologies.
Anonymous Group Message Authentication Protocol for LTE‐based V2X Communications
Authors: Liu Dongxiao , Ni Jianbing , Lin Xiaodong , Shen Xuemin (Sherman) 
Published: December 2017

AbstractCellular technologies, in particular the current long‐term evolution (LTE) and future 5G, are suitable for implementing vehicle‐to‐everything (V2X) services, due to the existing network infrastructure, device‐to‐device (D2D) communication capability, and guaranteed end‐to‐end delay. In LTE‐based V2X (LTE‐V), vehicle grouping plays an important role for improving LTE spectrum utilization and providing group‐oriented proximity‐based services (ProSe). However, the flourishing of LTE‐V group communications introduces unique privacy challenges. In this letter, the state‐of‐art standardization and research efforts are first reviewed, and their limitations are identified on achieving trajectory privacy for LTE‐V group communications. Then, an efficient and anonymous group message authentication protocol is proposed to support message batch verification. Security analysis and performance evaluation demonstrate the feasibility of the proposed protocol.
MicroRNA‐204 deregulation in lung adenocarcinoma controls the biological behaviors of endothelial cells potentially by modulating Janus kinase 2–signal transducer and activator of transcription 3 pathway
Authors: Liu Xiangdong , Gao Xiang , Zhang Wentao , Zhu Tianyi , Bi Wei , Zhang Yanrong 
Published: December 2017

AbstractMicroRNAs (miRNAs) have been implicated in a wide range of biological processes including angiogenesis. MiR‐204 was identified as a tumor suppressor in multiple cancer types, including lung adenocarcinoma. However, the function of miR‐204 in lung tumor angiogenesis remains unknown. In this study, we found that the miR‐204 expression was decreased in lung adenocarcinoma based on the cancer genome atlas (TCGA) analysis and gain‐of‐function experiment showed that miR‐204 promoted cancer cell apoptosis and suppressed cell proliferation, migration in vitro and tumor growth in vivo. Functionally, both the tube formation and migration abilities of human umbilical vein endothelial cells (HUVECs) were suppressed by conditioned media from lung cancer A549 cells with miR‐204 overexpression. Meanwhile, these conditioned media inhibited proliferation and promoted apoptosis in HUVECs. The key angiogenesis inducer hypoxia inducible factor‐1α (HIF1α) and the pro‐angiogenic mediators vascular endothelial growth factor and platelet‐derived growth factor were decreased in A549 cells transfected with miR‐204 mimics. Mechanistically, miR‐204 could target Janus kinase 2 (JAK2) and further impaired signal transducer and activator of transcription 3 both in vitro and in vivo. Inhibition of JAK2 or signal transducer and activator of transcription 3 (STAT3) activity with small chemical inhibitors in A549 cells impaired lung adenocarcinoma angiogenesis in vitro. Meanwhile, conditional media from interleukin 6‐treated lung normal epithelial cells significantly promoted tube formation of HUVEC, which was disturbed by miR‐204 overexpression. Taken together, our findings demonstrate that miR‐204 attenuates angiogenesis in lung adenocarcinoma potentially via JAK2‐STAT3 pathway. Clinically, the miR‐204/JAK2/STAT3 signaling pathway is a putative therapeutic target in lung adenocarcinoma. © 2017 IUBMB Life, 70(1):81–91, 2018
Three‐dimensional cultured tissue constructs that imitate human living tissue organization for analysis of tumor cell invasion
Authors: Iwai Soichi , Kishimoto Satoko , Amano Yuto , Nishiguchi Akihiro , Matsusaki Michiya , Takeshita Akinori , Akashi Mitsuru 
Published: December 2017

AbstractPreventing cancer metastasis requires a thorough understanding of cancer cell invasion. These phenomena occur in human 3‐D living tissues. To this end, we developed a human cell‐based three‐dimensional (3‐D) cultured tissue constructs that imitate in vivo human tissue organization. We investigated whether our 3‐D cell culture system can be used to analyze the invasion of human oral squamous cell carcinoma (OSCC) cells. The 3‐D tissue structure consisted of five layers of normal human dermal fibroblasts along with human dermal lymphatic endothelial cell tubes and was generated by the cell accumulation technique and layer‐by‐layer assembly using fibronectin and gelatin. OSCC cells with different lymph metastatic capacity were inoculated on the 3‐D tissues and their invasion through the 3‐D tissue structure was observed. Conventional methods of analyzing cell migration and invasion, that is, 2‐D culture‐based transwell and Matrigel assays were also used for comparison. The results using the 3‐D cultured tissue constructs were comparable to those obtained using conventional assays; moreover, use of the 3‐D system enabled visualization of differential invasion capacities of cancer cells. These results indicate that our 3‐D cultured tissue constructs can be a useful tool for analysis of cancer cell invasion in a setting that reflects the in vivo tissue organization. © 2018 The Authors. Journal of Biomedical Materials Research Part A published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 292–300, 2019.
Effect of Study Design on Sample Size in Studies Intended to Evaluate Bioequivalence of Inhaled Short‐Acting β‐Agonist Formulations
Authors: Zeng Yaohui , Singh Sachinkumar , Wang Kai , Ahrens Richard C. 
Published: December 2017

AbstractPharmacodynamic studies that use methacholine challenge to assess bioequivalence of generic and innovator albuterol formulations are generally designed per published Food and Drug Administration guidance, with 3 reference doses and 1 test dose (3‐by‐1 design). These studies are challenging and expensive to conduct, typically requiring large sample sizes. We proposed 14 modified study designs as alternatives to the Food and Drug Administration–recommended 3‐by‐1 design, hypothesizing that adding reference and/or test doses would reduce sample size and cost. We used Monte Carlo simulation to estimate sample size. Simulation inputs were selected based on published studies and our own experience with this type of trial. We also estimated effects of these modified study designs on study cost. Most of these altered designs reduced sample size and cost relative to the 3‐by‐1 design, some decreasing cost by more than 40%. The most effective single study dose to add was 180 μg of test formulation, which resulted in an estimated 30% relative cost reduction. Adding a single test dose of 90 μg was less effective, producing only a 13% cost reduction. Adding a lone reference dose of either 180, 270, or 360 μg yielded little benefit (less than 10% cost reduction), whereas adding 720 μg resulted in a 19% cost reduction. Of the 14 study design modifications we evaluated, the most effective was addition of both a 90‐μg test dose and a 720‐μg reference dose (42% cost reduction). Combining a 180‐μg test dose and a 720‐μg reference dose produced an estimated 36% cost reduction.
Volatile fatty acids production from cheese whey: influence of pH, solid retention time and organic loading rate
Authors: Calero Rolando Rafael , Lagoa‐Costa Borja , Fernandez‐Feal María Mercedes del Coro , Kennes Christian , Veiga Maria Carmen 
Published: December 2017

AbstractBACKGROUNDThe influence of pH, sludge retention time (SRT) and organic loading rate (OLR) were evaluated in the fermentation of cheese whey to produce volatile fatty acids (VFA) in a sequencing batch reactor (SBR). The reactor performance was studied at SRT of 4, 6 and 10 days and the influence of pH (5, 5.5 and 6) was determined at each SRT. The OLR effect was also studied in the range 3 to 12 g COD L‐1 d‐1, while keeping the other parameters mentioned above constant.RESULTSA more acidic pH , improved the degree of acidification at short SRT (4 and 6 days), reaching 76 and 84%, respectively, meanwhile at pH 6 the degree of acidification (DA) improved and reached 85% at longer SRT (10 d). Regarding the VFA profile, a pH shift from 5 to 6 stimulated the production of acetic and propionic acids, whereas the production of butyric and valeric acids decreased irrespective of the SRT applied. Moreover, the increase of SRT from 4 to 10 d boosted propionic and valeric acids production regardless of the pH applied. Lower OLR favoured the production of propionic and valeric acids, while higher OLR increased the production of butyric acid. Lactose degradation and VFA production followed the Michaelis–Menten model.CONCLUSIONA selective VFA distribution can be reached by modifying parameters such as pH, SRT and OLR in acidogenic reactors, therefore, they could be suitable for further valorisation purposes in the production of polyhydroxyalkanoates from such VFA. © 2017 Society of Chemical Industry
Characterization of polymer inclusion membranes (PIM) containing phosphonium ionic liquids and their application for separation of Zn(II) from Fe(III)
Authors: Baczyńska Monika , Słomka Żaneta , Rzelewska Martyna , Waszak Michał , Nowicki Marek , Regel‐Rosocka Magdalena 
Published: December 2017

AbstractBACKGROUNDHydrometallurgical separation of Zn(II) from Fe(III) from HCl solutions is an important issue to regenerate spent effluents. Polymer inclusion membranes (PIMs) are an attractive technique for selective separation and concentration of low concentrated target metal ions, as an alternative to liquid–liquid extraction.RESULTSPIMs containing phosphonium ionic liquids trihexyl(tetradecyl)phosphonium chloride (Cyphos IL101) or bis(2,4,4‐trimethylpentyl)phosphinate (Cyphos IL104), as metal ion carriers, o‐nitrophenyloctyl ether (NPOE) as a plasticizer and triacetate cellulose (CTA) as a polymer matrix were prepared and characterized by contact angle measurements, scanning electron microscopy, atomic force microscopy and nanoindentation measurements. An important aspect was to determine the influence of PIMs ageing on their morphology and efficiency of Zn(II) transport. Finally, PIMs were applied for separation of Zn(II) from Fe(III).CONCLUSIONThe surface of the IL‐containing PIMs was characterized as hydrophilic, rough, without apparent pores. However, phase contrast images indicated that the plasticized membranes were not fully homogeneous. Stability of the PIMs, particularly of those without the plasticizer or without the carrier, is affected by ageing. Finally, a membrane‐based successful separation of Zn(II) from Fe(III) was developed with 1 mol L‐1 HCl as a stripping phase for Fe(III), while the majority of Zn(II) were retained in the feed phase (SFe(III)/Zn(II) = 8.85). © 2017 Society of Chemical Industry
Potential of aqueous two‐phase systems for the separation of levodopa from similar biomolecules
Authors: Sousa Rita de Cássia S , Neves Catarina MSS , Pereira Matheus M , Freire Mara G , Coutinho João AP 
Published: December 2017

AbstractBACKGROUNDLevodopa is a precursor of several neurotransmitters, such as dopamine, and is used in the treatment of Parkinson's disease. In this work, an alternative strategy was studied to separate levodopa from similar biomolecules using aqueous two‐phase systems (ATPS).RESULTSTernary ATPS composed of polyethylene glycol (PEG) 400 or ionic liquids (ILs), citrate buffer (K3C6H5O7/C6H8O7) at pH 7.0 and water, and quaternary ATPS composed of PEG 400, K3C6H5O7/C6H8O7 at pH 7.0, water and the same ILs at 5 wt%, were studied. The respective liquid–liquid phase diagrams were determined at 298 K to appraise the mixture compositions required to form two‐phase systems, followed by studies of the partition of levodopa and structurally similar biomolecules (dopamine, L‐phenylalanine, and L‐tyrosine). Their partition coefficients and extraction efficiencies have been determined, and the selectivity of the ATPS to separate levodopa from the remaining biomolecules evaluated.CONCLUSIONThe results obtained indicated that PEG‐based ATPS were the most effective to separate levodopa from L‐phenylalanine while the separation from the other biomolecules was better using IL‐based ATPS, in particular those based on [P4444]Cl and [N4444]Cl, with extraction efficiencies of levodopa to the salt‐rich phase ranging between 62.7 and 74.0%, and of the remaining biomolecules to polymer/IL‐rich phase up to 91.5%. © 2017 Society of Chemical Industry