bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vast population genetic diversity underlies the treatment dynamics ofETV6-RUNX1acute lymphoblastic leukemia
Authors: Gonzalez-Pena Veronica , MacKay Matthew , De Vlaminck Iwijn , Easton John , Gawad Charles 
Published: March 2017

AbstractEnsemble-averaged genome profiling of diagnostic samples suggests that acute leukemias harbor few somatic genetic alterations. We used single-cell exome and error-corrected sequencing to survey the genetic diversity underlyingETV6-RUNX1acute lymphoblastic leukemia (ALL) at high resolution. The survey uncovered a vast range of low-frequency genetic variants that were undetected in conventional bulk assays, including additional clone-specific “driver” RAS mutations. Single-cell exome sequencing revealed APOBEC mutagenesis to be important in disease initiation but not in progression and identified many more mutations per cell than previously found. Using this data, we created a branching model ofETV6-RUNX1ALL development that recapitulates the genetic features of patients. Exposure of leukemic populations to chemotherapy selected for specific clones in a dose-dependent manner. Together, these data have important implications for understanding the development and treatment response of childhood leukemia, and they provide a framework for using population genetics to deeply interrogate cancer clonal evolution.One-Sentence SummaryAPOBEC and replication-associated mutagenesis contribute to the development of ETV6-RUNX1 ALL, creating massive leukemic population genetic diversity that results in clonal differences in susceptibilities to chemotherapy.
Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase
Authors: Asquith Christopher R. M. , Laitinen Tuomo , Bennett James M. , Godoi Paulo H. , Tizzard Graham J. , Elkins Jonathan M. , Willson Timothy M. , Zuercher William J. 
Published: March 2017

ABSTRACT4-Anilinoquinolines were identified as potent and narrow spectrum inhibitors of the cyclin G associated kinase (GAK), an important regulator of viral and bacterial entry into host cells. Optimization of the 4-anilino group and the 6,7-quinoline substituents produced GAK inhibitors with nanomolar activity and over 50,000-fold selectivity relative to other members of the numb-associated kinase (NAK) sub-family. These compounds may be useful tools to explore the therapeutic potential of GAK in prevention of a broad range of infectious diseases.
Genome-wide Segregation of Single Nucleotide and Structural Variants into Single Cancer Cells
Authors: Easton John , Gonzalez Pena Veronica , Yergeau Donald , Ma Xiaotu , Gawad Charles 
Published: March 2017

AbstractWe present a new approach for determining comprehensive variant profiles of single cells using a microfluidic amplicon-based strategy. This method can be used to reconstruct the clonal architecture and mutational history of a malignancy using all classes and sizes of single nucleotide and structural variants, providing insights into the temporal changes in mutational classes and processes that led to the development of a cancer. Using this approach, we interrogated single cells from a patient with leukemia, determining that processes producing structural variation preceded single nucleotides changes in the development of that malignancy.
Evaluating food safety risk messages in popular cookbooks
Authors: Levine Katrina , Chaifetz Ashley , Chapman Benjamin 
Published: March 2017

Purpose
Medeiros et al. (2001) estimate 3.5 million cases of foodborne illness in the USA annually are associated with inadequate cooking of animal foods or cross-contamination from these foods. Past research shows home food handling practices can be risk factors for foodborne illness. The purpose of this paper is to evaluate the communication of food safety guidance, specifically safe endpoint temperatures and cross-contamination risk reduction practices, in popular cookbook recipes.

Design/methodology/approach
Recipes containing raw animal ingredients in 29 popular cookbooks were evaluated through content analysis for messages related to safe endpoint temperature recommendations and reducing cross-contamination risks.

Findings
Of 1,749 recipes meeting study criteria of cooking raw animal ingredients, 1,497 contained a raw animal that could effectively be measured with a digital thermometer. Only 123 (8.2 percent) of these recipes included an endpoint temperature, of which 89 (72.3 percent) gave a correct temperature. Neutral and positive food safety behavior messages were provided in just 7.2 percent (n=126) and 5.1 percent (n=90) of recipes, respectively. When endpoint temperatures were not included, authors often provided subjective and risky recommendations.

Research limitations/implications
Further research is needed on the effect of these results on consumer behavior and to develop interventions for writing recipes with better food safety guidance.

Practical implications
Including correct food safety guidance in cookbooks may increase the potential of reducing the risk of foodborne illness.

Originality/value
Popular cookbooks are an underutilized avenue for communicating safe food handling practices and currently cookbook authors are risk amplifiers.
An evaluation tool for measuring food skills acquisition
Authors: Fordyce-Voorham Sandra 
Published: March 2017

Purpose
The purpose of this paper is to design an objective, valid and reliable “Checklist” tool that teachers could use to measure their students’ food skills acquisition.

Design/methodology/approach
The design of the Checklist was based on 18 procedural food skills identified by teachers and verified by analysis of skills in recipes that are typically used in food education programmes in secondary schools. The skills were divided into five skill-sets and a recipe covering the skills was selected to test the Checklist. For the test, three hypothetical situations of a person with low, some and expert skills making the recipe were demonstrated in separate videos. Teachers were invited to test the Checklist by viewing the videos, completing the Checklist for each of the three conditions and completing an evaluation.

Findings
In total, 40 home economics teachers tested the Checklist and reported that they could use the tool to measure the development and progress of their students’ procedural food skills. Analysis of variance analyses of the data and the non-parametric analyses suggest that the Checklist is a reliable and valid evaluation tool.

Originality/value
Teachers report using various tools to measure their students’ food skills acquisition but these have not been well-documented in the literature. These preliminary findings of an original and quantifiable tool showed that home economics teachers used the Checklist to measure their students’ procedural skills however, as the teachers’ comments suggest, further development and validation of the tool are required.
Older adults’ cooking trajectories: shifting skills and strategies
Authors: Bostic Stephanie Marie , McClain Amanda C. 
Published: March 2017

Purpose
The purpose of this paper is to explore how the cooking experiences of older adults living in the USA contributed to cooking skill development and cooking practices over their life course.

Design/methodology/approach
In total, 17 adults aged 60 and older living in two rural counties, who prepared at least three basic meals per week, were purposefully recruited to represent different living situations, perceived income level, and education level. Two retrospective in-depth interviews with each person collected biographical cooking narratives, analyzed using a life course perspective. Life course perspective concepts and emergent themes were identified. Timelines for each participant were prepared.

Findings
All participants expressed interest and pleasure in eating but they described different patterns of skills, behaviors, and feelings regarding cooking. Four cooking trajectories emerged: resilient, expanding, contracting interest, and contracting capability. Cooking skills evolved for some only during older adulthood, and supported both contracting and expanding food preparation. When cooking declined, it decreased due to shifts in personal priorities or in physical capability to carry out cooking tasks.

Practical implications
Recognizing the different patterns of cooking trajectories may help health care providers and the food industry better serve the diverse nutritional needs of older adults, including those not traditionally served: individuals who are actively seeking information as they increase their cooking and those who are avoiding cooking due to lack of interest.

Originality/value
Trajectories are a useful tool for analyzing skills and practices over time, which can facilitate understanding of food choice activities. Trajectories have not been previously used to explicitly examine cooking skills.
Comparative advantages of school and workplace environment in skill acquisition
Authors: Bolli Thomas , Renold Ursula 
Published: March 2017

PurposeThe purpose of this paper is to shed light on the questions as to how important skills are; which skills can best be learned at school, and which skills can be acquired better in the workplace.Design/methodology/approachThe authors exploit data from a survey among professional tertiary education and training business administration students and their employers in Switzerland.FindingsThe authors find that skills used in the business processes strategic management, human resource management, organizational design, and project management are most suitable to be taught in school. However, the results further suggest that soft skills can be acquired more effectively in the workplace than at school. The only exceptions are analytical thinking, joy of learning and organizational soft skills, for which school and workplace are similarly suitable.Practical implicationsThe paper provides empirical evidence regarding the optimal choice of the learning place for both human resource managers as well as educational decision makers who aim to combine education and training, e.g. in an apprenticeship.Originality/valueLittle evidence regarding the optimal learning place exists.
Developing radically new meanings through the collaboration with radical circles
Authors: Altuna Naiara , Dell’Era Claudio , Landoni Paolo , Verganti Roberto 
Published: March 2017

PurposeThe importance and complexity of proposing radically new meanings are well-established in the literature. However, a limited number of contributions have analyzed how they can be developed. The purpose of this paper is to analyze the development of radically new meanings at the basis of the Slow Food movement to contribute to the topic.Design/methodology/approachIn order to better understand how social movements can propose radically new meanings and how companies can take inspiration and build a competitive advantage by leveraging the proposed meanings, the authors deeply analyzed the genealogy of Slow Food, interpreted as an inspiring case study; the authors adopt a narrative approach.FindingsThe analysis of how Slow Food emerged and evolved into an international movement reveals an alternative way to develop innovative meanings in collaboration with groups of radicals. The authors identify three main phases in the evolution of innovative meanings: generation, institutionalization and development.Practical implicationsIn terms of managerial implications the authors contribute highlighting the importance of a new type of collaborative innovation: the collaboration with radical circles and social movements in their early stage.Social implicationsFrom a societal point of view, if the authors acknowledge the importance of social movements in contesting and actively changing institutions, the authors can see the importance for policy makers to create loci and opportunities for the emergence of radical circles and their experimentations.Originality/valueThe authors propose that new meanings are frequently the result of small groups of individuals gathering in radical circles. The core attribute of such circles is group validation. The group supports the Slow Food leader in refining the meaning and confronting the dominant paradigm.
Inter-organizational learning within an institutional knowledge network
Authors: Eiriz Vasco , Gonçalves Miguel , Areias João S. 
Published: March 2017

PurposeThe purpose of this paper is to focus on the interaction process between organizations of a knowledge network as a means to promote learning. In particular, the authors aim to answer the following research questions: how do dyadic and network relationships contribute to inter-organizational creation and transfer of knowledge? More specifically, which joint activities between organizations facilitate inter-organizational learning within a knowledge network? That is, the authors are interested in the relationship processes for inter-organisational learning, aiming to identify and understand the joint activities through which organizations within an institutional network generate and transfer knowledge.Design/methodology/approachAiming at studying how six institutional actors generate and transfer knowledge, the existing dyadic relationships between a focal actor (a technological center of the textile and clothing industry – CITEVE) and each one of the other five institutional actors were studied. In the study of this knowledge network the authors analyzed several documental sources and carried out 19 interviews.FindingsThis study shows how dyadic and network relationships contribute to inter-organisational creation and transfer of knowledge. It assesses several joint activities through which organizations in the studied network learn with each other and compares the five dyadic relationships in terms of their distinctive features. Through the cooperative effort based on joint activities between actors, the studied network generates complementary and multidisciplinary knowledge aiming to promote network learning of the studied organizations. Management implications and suggestions for further research on network learning are discussed.Originality/valueThis paper adds to the literature on network learning and management by empirically illustrating how a network of organizations in a given industry contributes to knowledge generation. It is an original contribution because, first, it allows a better understanding of how organizations of a knowledge network interact and contribute for network learning. In particular, the paper identifies a large number of joint activities for inter-organizational learning in the context of a traditional industry. Second, the research shows empirically how such interaction and learning occur in practice within a network context that comprises only institutional actors.
A mapping for managers: open innovation for R&D intensive SMEs in the life sciences sector
Authors: Marangos Stefanos , Warren Lorraine 
Published: March 2017

PurposeThe purpose of this paper is to examine what strategies the CEOs of research and development (R&D) intensive small/medium enterprises (SMEs) in the life sciences sector carry out in regard to open innovation (OI), as R&D costs continue to rise, placing pressure on innovation managers.Design/methodology/approachA qualitative study was carried out, consisting of 30 semi-structured interviews with CEOs of small R&D intensive SMEs in the life sciences sector. The authors analysed the key factors identified by the CEOs in relation to their OI strategies.FindingsSMEs adopt a range of OI strategies and collaborations, subject to certain conditions. A multilevel mapping developed from the analysis connects actors to the wider domain, setting the outcomes of the research in context.Research limitations/implicationsThis qualitative study provides detailed understandings that could provide the basis for a wider quantitative study that would provide greater coverage of the sector, thus reinforcing the outcomes.Practical implicationsThe study will be relevant to practising CEOs who are considering the range of options offered by OI.Originality/valueWhile large firms are adopting OI strategies, less is known about the OI strategies developed in SMEs. The study addresses that gap. The life sciences context is also novel.
Training and development
Authors: Rowland Caroline Ann , Hall Roger David , Altarawneh Ikhlas 
Published: March 2017

Purpose
The purpose of this paper is to explore the relationship between organizational strategy, performance management and training and development in the context of the Jordanian banking sector.

Design/methodology/approach
Models of strategic human resource management developed in the west are considered for their relevance in Jordan. A mixed methods approach is adopted employing interviews with senior managers and training and development managers, employee questionnaires and documentary analysis. It examines all banks in Jordan including foreign and Islamic banks.

Findings
Findings indicate that training and development is not driven by human resource strategy and that it is reactive rather than proactive. Training and development does improve skills, knowledge, attitudes and behaviors but there is little evidence that it increases commitment and satisfaction nor that it contributes to strategic aims in any significant way. The linkages between strategy and training and development are not explicit and strategies are not interpreted through performance management systems. Consequently there is a lack of integration in organizational HR systems and the measurable contribution of training and development to competitive advantage is minimal

Practical implications
The paper offers suggestions as to how greater integration between strategy, performance management and training and development might be achieved in the Jordanian context.

Originality/value
This paper is the first detailed empirical study of training and development in Jordan to include considerations of transferability of western models to an Arab culture.
Investigating the impact of donor funding: a case study on Lebanon
Authors: Saleh Ali Salman , Harvie Charles 
Published: March 2017

Purpose
The purpose of this paper is to develop a macroeconomic framework to predict the impact of transient donor funding on a developing economy and to facilitate evaluation of the effectiveness of alternative uses of this funding in attaining the desired outcomes.

Design/methodology/approach
A simulation analysis of the macroeconomic impact of donor funding on the Lebanese economy is conducted.

Findings
The paper evaluates the potential outcomes for the country from alternative uses of this donor funding and concludes that targeting infrastructure expenditure, mediated through the government, will produce the most beneficial longer term outcomes.

Originality/value
This paper is the first substantive macro model to be developed for the Lebanese economy. It is the first major study of the contribution of donor funding to the Lebanese macro-economy. The framework, however, can be generalised to other developing donor recipient nations.
The establishment of carbon trading market in People’s Republic of China
Authors: Nai Peng , Luo Yuqing , Yang Guang 
Published: March 2017

Purpose
This study aims to propose a set of institutional frameworks, as well as practical polices and steps, with a view to facilitating the establishment of a unified carbon trading market in China.

Design/methodology/approach
Based on existing empirical studies and reviews of the socioeconomic contexts, this study followed a qualitative approach consisting of secondary data collection and analysis, semi-structured interviews to collect primary data and comparative analysis.

Findings
The establishment of a national carbon trading market in China is a systemic and complex process which requires coordination among various concerned government agencies and supporting mechanisms. Currently, the development of a unified national carbon market has been impeded by the lack of coordination among local pilot programs, and there is no specific law passed by the People’s Congress or by its Standing Committee to regulate the emerging carbon trading market. It is of vital importance for China, in terms of both practical and strategic aspects, to take a gradualist approach in establishing laws and institutions to guide and support the development of its emerging carbon market.

Research limitations/implications
This present study forms a part of a regional research project aiming to identify sound policy approaches for the establishment of a carbon trading market in China. Due to scope reasons, it focuses only on policy analysis and recommendations.

Originality/value
China’s emerging national carbon trading market has attracted much research attention. However, little has been done from the perspectives of legislations and policies.
The vulnerability of shrimp farming income to climate change events
Authors: Quach An Van , Murray Frank , Morrison-Saunders Angus 
Published: March 2017

Purpose
This paper aims to investigate shrimp income losses of farmers in the four farming systems in the research areas of Ca Mau, Vietnam, and determine the vulnerability of shrimp farming income to climate change events.

Design/methodology/approach
Field research interviews were conducted with 100 randomly selected households across the four farming systems to access shrimp income status and vulnerability levels to climate change events. Four focus groups, each aligned to a particular farming system, were surveyed to categorise likelihood and consequences of climate change effects based on a risk matrix worksheet to derive levels of risk, adaptive capacity and vulnerability levels.

Findings
Shrimp farmers in the study areas have been facing shrimp income reduction recently and shrimp farming income is vulnerable to climate change events. There are some differences between farmers’ perspectives on vulnerability levels, but some linkages are evident among shrimp farmer characteristics, ramifications for each farming system, shrimp income losses and shrimp farmers’ perspectives on vulnerability levels of shrimp incomes. From an income perspective, farmers operating in intensive shrimp farming systems appear to be less vulnerable to existing and expected climate change effects relative to those in mixed production or lower density systems.

Originality/value
Having identified the vulnerability level of shrimp farming income to climate change events in different farming systems based on shrimp farmers’ perspectives, the paper adds new knowledge to existing research on vulnerability of the aquaculture sector to climate change. The research findings have implications for policymakers who may choose to encourage intensive shrimp farming to enhance shrimp farmer resilience to the effects of climate change as well as improving cultivation techniques for shrimp farmers. The findings could thus guide local government decision-making on climate change responses and residents of Ca Mau as well as within the wider Mekong Delta in developing suitable practical adaption measures.