bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic analysis of drug resistance mechanisms and phylogenetic clustering in Candida auris isolates from Western India
Authors: Chheda Pratiksha , Shivaprakash Shashikala , Gupta Naina , Dama Tavisha , Biyani Neetu , Bansode Seema 
Published: October 2024

Objectives:
Candida auris is an emerging multidrug-resistant fungal pathogen that poses a significant threat to global health. Limited information is available from the Indian subcontinent regarding mutations associated with drug resistance and genetic variability among the isolates. In this study, we employed whole-genome sequencing (WGS) to investigate the genetic variations and drug resistance mechanisms within C. auris isolates from the western region of India.

Materials and Methods:
A total of twenty archived isolates were subjected to WGS on the Illumina NextSeq 2000 platform. A set of 18 genes was analyzed to check for the presence of drug-resistant mutations. Phylogenetic analysis was done using MEGA v6.06 software to identify the C. auris subgroup or clade and to check genetic relatedness among species.

Statistical analysis:
The data related to drug resistance were presented in numbers and percentages.

Results:
Through manual analysis, drug-resistant mutations were detected in ERG11, CDR1, and TAC1b genes, which are known to be associated with reduced susceptibility to antifungal agents. Phylogenetic analysis revealed that all the isolates clustered within Clade I, indicating a high degree of genetic similarity among isolates. The absence of comprehensive antifungal mutation databases and automated tools for drug resistance detection necessitated the utilization of specialized computational skills of bioinformaticians for data analysis.

Conclusions:
The study provides valuable insights into the genetic diversity and drug resistance mechanisms of C. auris isolates in the western region of India and emphasizes the need for continued research and surveillance to combat this emerging pathogen. Our findings underscore the need for the development of user-friendly automated tools and comprehensive databases to facilitate rapid and accurate identification of drug resistance in C. auris.
Случай гипертрипсиногенемии при частичной трисомии хромосомы 13
Authors: Репникова А.Р. , Прокопцева Ж.В. , Ким М.Д. , Галиуллина Г.Р. , Костырко Э.И. , Самсоненко М.С. 
Published: October 2024

Неонатальная гипертрипсиногенемия (при скрининговом и ретестном исследовании в 21–28 дней жизни в группе риска) должна расцениваться не только в качестве диагностического критерия муковисцидоза, но и как признак других заболеваний и состояний у новорожденного, в том числе структурных хромосомных аномалий. Это поможет своевременно диагностировать патологию и корректировать лечебные мероприятия в более раннем возрасте. В статье описан клинический случай гипертрипсиногенемии при частичной трисомии 13 хромосомы. Также рассмотрены возможные причины повышения иммунореактивного трипсина в рамках неонатального скрининга. Приведены данные ретроспективного анализа историй болезни пациентов с гипертрипсиногенемией.
Neonatal hypertrypsinogenemia (in screening and retest) should be regarded not only as a marker of cystic fibrosis, but also as a sign of other diseases and conditions, incl. structural chromosomal rearrangements. This will help to diagnose pathology in a timely manner and correct therapeutic measures at an earlier age. The article describes a clinical case of hypertrypsinogenemia with partial trisomy of chromosome 13. Various reasons for the increase in immunoreactive trypsin as part of neonatal screening are also considered. The data of a retrospective analysis of the case histories of patients with hypertrypsinogenemia are presented.
Южные алтайцы: различия в структуре генофонда теленгитов и алтай-кижи по данным X-STR маркеров
Authors: Вагайцева К.В. , Валихова Л.В. , Колесников Н.А. , Харьков В.Н. , Бочарова А.В. , Волкова И.А. , Степанов В.А. 
Published: October 2024

В кратком сообщении представлены результаты анализа генетического разнообразия и структуры неравновесия по сцеплению в двух популяциях южных алтайцев: теленгитов и алтай-кижи. Анализ проводился с использованием мультиплексного набора TYPER X-19, включающего 18 STR-маркеров, локализованных на X-хромосоме. Продемонстрирована специфичность генетической структуры двух этносов, Выявлены различия в структуре неравновесия по сцеплению. Проведена оценка уровня исключающей способности 18 X-STR для ДНК-идентификации.
The brief report presents the results of the analysis of genetic diversity and the structure of linkage disequilibrium in two populations of southern Altaians: Telengites and Altai-Kizhi. The analysis was performed using the TYPER X-19 multiplex set, which includes 18 STR markers localized on the X chromosome. The specificity of the genetic structure of the two ethnic groups is demonstrated, and differences in the structure of linkage disequilibrium are revealed. The assessment of the level of identification informativeness of 18 X-STR for DNA identification was carried out.
Разработка интеллектуальных моделей проактивной защиты критической инфраструктуры финансового сектора на примере информационного обеспечения контрактных систем
Authors: Корчагин С.А. , Рубцов Д.Ю. , Беспалова Н.В. , Сердечный Д.В. 
Published: October 2024

В работе предлагается подход к разработке интеллектуальных моделей проактивной защиты, ориентированный на информационное обеспечение контрактных систем в финансовом секторе. Представлена методология разработки интеллектуальных моделей, включающая в себя компоненты мониторинга, прогнозирования и предупреждения кибератак. Предложенная методология легла в основу практической реализации на языке Python с использованием библиотек Numpy и Scirket Learn. Особое внимание уделяется использованию передовых алгоритмов машинного обучения и искусственного интеллекта для выявления и предотвращения потенциальных угроз в режиме реального времени. В качестве практического примера рассматривается применение разработанных интеллектуальных моделей для защиты информационного обеспечения контрактных систем, используемых в финансовом секторе. Анализируются ключевые уязвимости, потенциальные атаки и методы их упреждающего обнаружения и блокирования. Результаты исследования подтверждаются данными вычислительного эксперимента и демонстрируют высокую эффективность предлагаемого подхода в повышении устойчивости критической информационной инфраструктуры финансового сектора к кибератакам. Внедрение интеллектуальных моделей проактивной защиты позволяет значительно снизить риски нарушения целостности и доступности ключевых данных, минимизировать финансовые и репутационные потери, а также прогнозировать и предупреждать потенциальные угрозы.
The paper proposes an approach to developing intelligent models of proactive protection focused on information support of contract systems in the financial sector. A methodology for developing intelligent models is presented, which includes components for monitoring, forecasting and preventing cyberattacks. The proposed methodology formed the basis for practical implementation in Python using the Numpy and Scirket Learn libraries. Particular attention is paid to the use of advanced machine learning and artificial intelligence algorithms to identify and prevent potential threats in real time. As a practical example, the application of the developed intelligent models to protect the information support of contract systems used in the financial sector is considered. Key vulnerabilities, potential attacks and methods for their proactive detection and blocking are analyzed. The results of the study are confirmed by the data of a computational experiment and demonstrate the high efficiency of the proposed approach in increasing the resilience of the critical information infrastructure of the financial sector to cyberattacks. The implementation of intelligent models of proactive protection allows us to significantly reduce the risks of compromising the integrity and availability of key data, minimize financial and reputational losses, and predict and prevent potential threats.
THE REALITY OF DATE PRODUCTION IN ALGERIA AND ITS RELATIONSHIP WITH NATIONAL INCOME: AN ECONOMETRIC STUDY USING THE AUTOREGRESSIVE DISTRIBUTED LAG (ARDL) MODEL DURING THE PERIOD 2000-2019
Authors: Mokadem Leila , Hadjadj Mourad , Zergoune Mohamed 
Published: October 2024

Objective: The objective of this study is to investigate the evolution of date production in Algeria and its impact on the country's national income (GDP) from 2000 to 2019. This research aims to analyze the short-term and long-term relationships between date production and national income, assessing the significance of agricultural policies in enhancing the productivity and economic contribution of the date sector. Ultimately, the study seeks to highlight the role of date production in diversifying Algeria's exports and contributing to sustainable economic growth.

Theoretical Framework: This study explores the relationship between date production and national income in Algeria, using agricultural productivity theory, endogenous growth theory, export diversification theory, and the ARDL model. It aims to understand the impact of agricultural policies, human capital investment, and export diversification on Algeria's date production, highlighting the potential for economic diversification.

Method: This study analyzes the relationship between date production and Algeria's GDP from 2000 to 2019, using the Autoregressive Distributed Lag (ARDL) model. Data sources include Algeria's GDP and date production data. The study uses unit root tests, bounds testing, and error correction models to estimate the relationship. Statistical software like EViews or R is used for analysis.

Results and Discussion: The study reveals a positive relationship between date production and national income in Algeria from 2000 to 2019. The data suggests that agricultural policies have led to an upward trajectory in date production, while GDP has grown significantly. The study also highlights the importance of date production in Algeria's economy, particularly in diversifying exports. The long-term relationship suggests sustained investment in date production will yield continued benefits for national income.

Research Implications: The study highlights the importance of supporting agricultural policies that enhance productivity in Algeria's date sector. It suggests broader export diversification strategies, infrastructure development, and economic development. Strengthening date production can create job opportunities, stimulate rural development, and contribute to food security. Future research should explore other agricultural products, climate change, and technological innovations to improve yields and sustainability in the sector.

Originality/Value: The study explores Algeria's date production and national income relationship, providing insights for policymakers to diversify the economy beyond hydrocarbons and foster sustainable growth.
Obituary: A life devoted to bee protection: the legacy of Pieter Oomen
Authors: Pistorius Jens , Steeger Thomas , Alix Anne , Thompson Helen , Smagghe Guy , Van der Steen Sjef , Kevan Peter 
Published: October 2024

Dr. Pieter Oomen, born in 1946, a prominent and inspirational scientist in many areas of the biosafety of pesticides, most notably ecotoxicology, regulatory, risk assessment and bioassays, passed away peacefully on 19th of January 2024. His efforts have had a great and long-lasting impact on bee risk assessment and have improved bee protection. While we will miss a very warm and brilliant person; his many contributions to science and our ability to detect and mitigate risks to the environment remain.
MOLLUSCAN DIVERSITY THE MANGROVE ECOSYSTEM OF TARAKAN ISLAND INDONESIA
Authors: Nugroho Bimo Aji , Erisa Ayu Waspadi Putri  
Published: October 2024

Mangrove in Tarakan coast encounter various underlined threat named pollution, habitat destruction, and the swelling of human population impending the existence of Molluscan communities. Molluscan is an essential component of Mangrove ecosystem since it could be as predator, herbivore, detritivore, and biofilter as well. However, there only minimum study found investigate the impact of Mangrove. This study, which was conducted from March to August 2023 in five mangrove regions of Tarakan Island, uncovered the distribution of 54 molluscan species, of which 46 were gastropods and 8 were bivalves. This study has identified a remarkable number of species, among the greatest among mangrove ecosystems in Indonesia. Additionally, this study provides an initial account of the distribution of gastropods in the mangrove region of Tarakan Island. The region north of Tarakan Island known as the Juwata mangrove forest harbors the greatest variety of molluscan. A comprehensive documentation of the molluscan species diversity in the mangrove ecosystem adjacent to Tarakan Island's coast has been compiled in order to furnish conservation management with fundamental data that is practical and beneficial.
Pengaruh Model Pembelajaran Discovery Learning dan Minat Belajar Terhadap Hasil Belajar Fisika Peserta Didik
Authors: Rasyid Juniar , Ali Muhammad Sidin , Palloan Pariabti 
Published: October 2024

Abstrack: Penelitian ini adalah true experimental design dengan menggunakan desain faktorial 2x2. Tujuan penelitian untuk: 1) menemukan ada atau tidaknya pengaruh penerapan model pembelajaran discovery learning dan minat belajar terhadap hasil belajar fisika kelas XI MIPA, dan 2) mendiagramkan interaksi model pembelajaran dan minat belajar terhadap hasil belajar fisika. Variabel bebas dalam penelitian ini adalah model pembelajaran, variabel moderator adalah minat belajar dan variabel terikat adalah hasil belajar fisika. Sampel dalam penelitian ini diambil secara acak dengan teknik simple random sampling yang menghasilkan kelas XI MIPA 2 dan XI MIPA 3 sebanyak 60 orang. Data hasil penelitian diperoleh dengan memberikan lembar kuesioner minat belajar pada peserta didik sebelum diajar menggunakan model pembelajaran, dan untuk tes hasil belajar dikerjakan setelah peserta didik diajar menggunakan model pembelajaran dalam penelitian. Teknik analisis data yang digunakan yaitu analisis varians (anava). Berdasarkan hasil analisis inferensial diperoleh: 1) Fhitung (9,6) > Ftabel (1,3) maka dapat disimpulkan terdapat perbedaan signifikan antara peserta didik yang diajar model pembelajaran discovery learning dengan peserta didik yang diajar menggunakan model pembelajaran inquiry based learning, 2) Fhitung (0,1) < Ftabel (1,3) maka dapat disimpulkan tidak terdapat interkasi antara model pembelajaran dan minat belajar terhadap hasil belajar fisika.

Keywords: Model Pembelajaran Discovery Learning, Model Pembelajaran Inquiry Based Learning, Minat Belajar Fisika, Hasil Belajar.
Meta-análise: uma abordagem prática
Authors: Oliveira Rita de Cássia Silva de , Brito Giovana Pereira Lobato , Hatano Cecilia Harumi Martins 
Published: October 2024

Nesse material técnico-didático digital ressaltamos a meta-análise como fonte de evidência clara e precisa para embasamento da tomada de decisões em saúde. Os capítulos desse ebook trazem informações sobre cada etapa do processo de construção de uma meta-análise, desde a formulação da pergunta de pesquisa até as implicações práticas de uma revisão meta-analítica.
in-text ref citation test High-pressure Hydrodynamic Injection as a Method of Establishing Hepatitis B Virus Infection in Mice
Authors: Wen Juan , Chen Guoli , Wang Tianshun , Yu Wan , Liu Zhengyun , Wang Huan 
Published: October 2024

Abstract
Among several existing mouse models for hepatitis B virus (HBV) infection, the high-pressure hydrodynamic injection (HDI) method is frequently used in HBV research due to its economic advantages and ease of implementation. The use of the HDI method is influenced by factors such as mouse genetic background, age, sex, and the type of HBV plasmid used. This overview provides a multidimensional analysis and comparison of various factors that influence the effectiveness of the HBV mouse model established through HDI. The goal is to provide a summary of information for researchers who create HBV models in mice.
The Specter of the Dangerous Classes
Authors: Martin Alexander M. 
Published: October 2024

Abstract
This article examines a formative moment in Russian social thought. The origins of modern research about urban society lie in the years after 1815, when French and British writers developed new methods for analyzing poverty, crime, and other aspects of city life. This literature, especially in the aftermath of the cholera pandemic and revolutions of 1830–1832, painted an alarming picture of slums teeming with “dangerous classes” of paupers and criminals. Russians joined this discussion with three books about Moscow and St. Petersburg by Vasilii Androssov, Aleksandr Bashutskii, and Andrei Zablotskii-Desiatovskii. These authors adopted the new Western research methods but claimed that Russia was free of “dangerous classes” of the Western type thanks to the unique virtues of the imperial regime and the Russian folk. The article argues that these writers helped to give 19th century Russian social research both its methodological sophistication and its distinctive ideological voice.
Michel de Certeau: a Jesuit Apologist
Authors: Ward Graham 
Published: October 2024

Abstract
While recognizing that Michel de Certeau is not a Christian theologian, this essay argues for a way in which we might read his oeuvre as a mode of Jesuit apologetics. The basis for reading him as such is twofold. First, Certeau pays attention to the various movements of desire beneath the signs composing the discourses in the various fields of his enquiry. In tracing that transgressive desire, he is always to listening for the voice of the Other; an Other that transcends and subtends human language, but resists capture by it. Secondly, the style in which he writes allows for the ambiguities and ironies that must necessarily attend any attempt to give definitive voice to the Other. Examining these two aspects of Certeau’s oeuvre reveals a way, this essay argues, his work bears witness to the Unnamed in the secular world in which he works and the secular studies in which he engages.
Pengaruh Dukungan Orang Tua, Motivasi Belajar, dan Minat Belajar Antropologi Terhadap Hasil Belajar Antropologi di SMAS K St. Arnoldus Mukun
Authors: Desta Matilda Serfi 
Published: October 2024

Tujuan penelitian ini adalah (1) untuk mengetahui adanya pengaruh dukungan orang tua, motivasi belajar dan minat belajar terhadap hasil belajar antropologi siswa di SMAS K St. Arnoldus Mukun, (2) untuk mengetahui adanya pengaruh dukungan orang tua terhadap hasil belajar antropologi siswa di SMAS K St. Arnoldus Mukun, (3) untuk mengetahui adanya pengaruh motivasi belajar terhadap hasil belajar antropologi siswa di SMAS K St. Arnoldus Mukun, (4) untuk mengetahui adanya pengaruh minat belajar antropogi terhadap hasil belajar siswa di SMAS K St. Arnoldus Mukun. Penelitian ini menggunakan pendekatan deskriptif kuantitatif. Pengumpulan data menggunakan kuesioner dan hasil belajar siswa. Sumber data dalam penelitian ini adalah siswa/siswi kelas XI jurusan Bahasa dan IPS. Alat analisis menggunakan SPSS version 22 for windows. Hasil analisis data secara simultan menunjukan pengaruh positif signifikan. Hasil dari penelitian ini adalah berpengaruh positif signifikan.
СУЧАСНІ ЗАСАДИ ФОРМУВАННЯ ЗБРОЙНИХ СИЛ НАТО ЯК ОСНОВА ЗАБЕЗПЕЧЕННЯ МІЖНАРОДНОЇ БЕЗПЕКИ
Authors: Біліченко Вадим 
Published: October 2024

У статті проаналізовані сучасні засади формування збройних сил НАТО як основа забезпечення міжнародної безпеки. Зазначено, що у Великобританії існує ретельний відбір кадрів у збройні сили. Комплектування збройних сил у Великобританії здійснюється на добровільній основі. Підготовка офіцерського корпусу характеризується цілісністю і безперервністю. Значна увага приділяється прищепленню курсантам (слухачам) командирських (лідерських) навичок, заняттям спортом та участі в тактичних навчаннях. У Великобританії існує принцип кар’єрного розвитку офіцерського складу. Його суть полягає в тому, що врахування різних кадрових дій (ротації, призначення на посади, присвоєння звань тощо) проводиться не на підставі вікових показників, а на підставі вислуги (термінів) проходження військової служби. Крім того, близько 30% кадрових офіцерів у збройних силах Великобританії проходили навчання на курсах позавійськової підготовки при цивільних закладах вищої освіти.
У частинах та підрозділах збройних сил Німеччини професійна підготовка складається з навчання та бойової підготовки. Кадри у збройних силах ретельно відбираються, враховуючи освіту, яку вони мають, а також навички та досвід. Система підготовки офіцерів Німеччини являє собою низку етапів навчання в офіцерській школі родів військ, в одному з університетів бундесверу, військового стажування та безпосередньої служби у військах на різних штабних і командних посадах. У збройних силах Німеччини психологічна підготовка вважається обов’язковою для військовослужбовців всіх родів військ, яка включає підготовку до бойових дій, стресостійкість, мотиваційні фактори до військової служби, подолання конфліктів тощо.
У Франції існують військові ліцеї, які надають початкову освіту. Система підготовки офіцерів має багатоступеневу освіту та постійний відбір кадрів. У Франції створена суттєва матеріальна підтримка військовослужбовців, зокрема відповідна заробітна плата, надбавки за особливі умови служби, призначені для компенсації ризиків, переміщення та тривале перебування закордоном; сприяння у купівлі або оренді житла; допомога членам сімей у працевлаштуванні, допомога у реабілітації після звільнення зі служби, пенсійне забезпечення тощо.
Dampak Harga dan Citra Merek terhadap Minat Beli Ulang yang Dimediasi oleh Kepuasan Pelanggan pada Produk Sabun Mandi Batang Merek Lifebuoy di Kota Bandung
Authors: Azhari Anisa Listia , Putra Hariyadi Triwahyu 
Published: October 2024

This study aims to analyze the effect of price and brand image on repurchase intention of Lifebuoy brand bath soap products in Bandung City, with customer satisfaction as a mediating variable. Data were collected through instruments that had been tested for reliability and validity, with a sample of 120 respondents who had used the product. The sampling technique used was purposive sampling, and this study used a cross-sectional approach. Data analysis was carried out using descriptive test methods and multiple linear regression using SPSS version 23, as well as the Sobel test to test mediation. The results showed that price and brand image significantly influenced repurchase intention, and customer satisfaction acted as a mediator in the relationship. In conclusion, this study provides new insights related to the factors that influence repurchase intention, especially in the context of Lifebuoy bath soap bars in Bandung City, and is expected to be a reference for managers in designing more effective marketing strategies.
Keywords: Price, Brand Image, Customer Satisfaction, Repurchase Intention