bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced ferritin levels in individuals with non‐O blood group: results from the Danish Blood Donor Study
Authors: Rigas Andreas S. , Berkfors Adam A. , Pedersen Ole B. , Sørensen Erik , Nielsen Kaspar R. , Larsen Margit H. , Paarup Helene M. , Wandall Hans H. , Erikstrup Christian , Hjalgrim Henrik , Ullum Henrik 
Published: October 2017

BACKGROUNDGenomewide association studies have reported alleles in the ABO locus to be associated with ferritin levels. These studies warrant the investigation of a possible association between the ABO blood group and ferritin levels. We aimed to explore if ABO blood group is associated with iron stores expressed as ferritin levels.STUDY DESIGN AND METHODSFerritin levels were measured at least once for 30,595 Danish Blood Donor Study participants. Linear regression analyses were performed with the ABO blood group as explanatory variable and adjusted for age, number of donations 3 years before the ferritin measurement, and time since latest donation. In addition, a subanalysis was performed on 15,280 individuals in which further adjustments for body mass index, smoking status, and C‐reactive protein levels were possible. Furthermore, logistic regression analyses were performed to determine if ABO blood group was associated with a ferritin level of less than 15 ng/mL.RESULTSNon‐O blood group donors had lower ferritin levels than blood group O donors, regardless of sex. Accordingly, risk of ferritin level of less than 15 ng/mL was increased for individuals with non‐O blood group compared with O blood group. In subanalyses similar associations were observed, albeit in women the association between blood group and risk of a ferritin level below 15 ng/mL was no longer significant. ABO blood group was not associated with red blood cell indices such as mean cell volume and mean cell hemoglobin content.CONCLUSIONDonors with non‐O blood group have lower ferritin levels than donors with other blood groups.
Tacrolimus therapy for dermal arteritis of the nasal philtrum refractory to surgery and anti‐inflammatory therapy (doxycycline/niacinamide and topical fluocinolone) in a dog
Authors: Banovic Frane , Jerry Carmen , Howerth Elizabeth 
Published: October 2017

BackgroundDermal arteritis of the nasal philtrum is a rarely reported condition commonly affecting large breed dogs.ObjectiveTo describe the effective treatment of nasal philtrum arteritis with topical tacrolimus in one dog.AnimalA 9‐year‐old, intact male German shorthair pointer dog was presented with well‐demarcated deep erythematous ulcers targeting exclusively the skin of the nasal philtrum, accompanied by frequent series of haemorrhage.MethodsComplete blood count, serum chemistry profile, urinalysis, histopathological examination and immunohistochemistry of skin biopsies.ResultsThe presence of a V‐shaped ulcer with subendothelial spindle cell proliferation resulting in stenosis of dermal arteries and arterioles on histological evaluation, together with a well‐demarcated deep nasal philtrum ulcer was consistent with arteritis of the nasal philtrum. Treatment was initiated with twice daily oral doxycycline and niacinamide in conjunction with topical fluocinolone cream. Over the course of two years, the lesions progressed with frequent bleeding episodes. A novel surgical approach provided deep resection of all grossly affected tissue; four months later a recurrence of fissures and occasional mild bleeding from the original site was noted and there was no improvement after another two months of oral doxycycline/niacinamide and topical fluocinolone treatment. Topical application of 0.1% tacrolimus twice daily resulted in complete healing of the ulceration and normalization of the epidermis. Over the subsequent 15 months, the dog's lesions remained in remission with topical tacrolimus application twice daily.Conclusions and clinical importanceTopical tacrolimus ointment appeared effective at inducing and maintaining lesion remission in this dog with nasal philtrum arteritis.
Accuracy and safety of pin placement during lateral versus dorsal stabilization of lumbar spinal fracture‐luxation in dogs
Authors: Tran Joycelyn H. , Hall David A. , Morton John M. , Deruddere Kirsten J. , Snelling Samuel R. 
Published: October 2017

AbstractObjectiveTo determine the accuracy and safety of pin placement for lateral vertebral stabilization to the reference dorsal stabilization.Study designA randomized noninferiority trial.Sample populationTwenty Greyhound cadaveric lumbar spines (L1‐L6).MethodsOne hundred and fifty‐nine lumbar vertebral pins placed in 80 vertebrae were assessed; these pins were distributed approximately equally between the dorsal and lateral approaches, and between 2 surgeons. Pin angle accuracy, bone purchase distance, and distances from pin to the spinal canal and the aorta were measured for each pin.ResultsThe lateral approach was superior for pin angle accuracy and bone purchase. The mean angle of deviation was 15.3° with the dorsal approach and 7.0° with the lateral approach. The mean bone purchase was 16.7 mm with the dorsal approach and 22.2 mm with the lateral approach. Pins were placed at a mean of 2.3 mm from the spinal canal with the dorsal approach and 1.7 mm with the lateral approach. Pins were placed at a mean of 3.8 mm from the aorta with the dorsal approach and 8.0 mm with the lateral approach. The percentage of pins breaching the spinal canal was 14% with the dorsal approach and 19% with the lateral approach. Fourteen percent of pins placed via the dorsal approach breached the aorta, whereas no pins placed via the lateral approach breached the aorta.ConclusionRelative to the dorsal approach, the lateral approach improves angle accuracy, bone purchase, and distance between pins, and the aorta and is noninferior with regards to the distance between pins and the spinal canal.
Limb shortening as a strategy for limb sparing treatment of appendicular osteosarcoma of the distal radius in a dog
Authors: Boston Sarah E. , Skinner Owen T. 
Published: October 2017

AbstractObjectiveTo develop and report a novel limb sparing technique for the distal radius in a dog.Study designCase report.AnimalA 14‐year‐old, female spayed Labrador Retriever with an osteosarcoma of the right distal radius and a pathological fracture. A previous mast cell tumor had been treated 5 years prior to presentation with marginal excision and a full‐course radiation over the right metacarpal bones. The dog had received 2 doses of palliative radiation just prior to presentation.MethodsA standard resection of the distal radius was used as a strategy to salvage the limb. Instead of replacing the 6‐cm bone defect with an endoprosthesis, the limb was acutely shortened and a carpal arthrodesis plate was applied.ResultsPostoperative function was good and limb shortening was well‐tolerated. Radiographic evidence of early bone healing was noted at the osteotomy site. The dog experienced 3 postoperative complications: a focal area of skin necrosis managed successfully via surgical revision; infection resolving after long‐term antibiotherapy; and a fracture of the third metacarpal bone through a screw hole, managed via screw removal and a custom external prosthesis. The patient was euthanatized due to presumptive chemotherapy complications 127 days after the procedure.ConclusionLimb shortening limb salvage is technically feasible and can result in excellent limb use postoperatively, in spite of a significant loss in limb length.
Arthroscopic approach and anatomy of the stifle joint in the rabbit
Authors: Peters Sarah Torrey , Wilke Markus , Schmid Tanja 
Published: October 2017

AbstractObjectiveTo describe a technique and normal findings for arthroscopy of the stifle in rabbits.Study designCadaver study.AnimalsTwenty cadaveric stifles from New Zealand White rabbits were examined.MethodsThe arthroscope was placed through a medial portal, and instrument portals were created on the lateral aspect of the joint. The same portals were used for examination of the entire joint and palpation of structures with a probe.ResultsStructures identified in the proximal aspect of the stifle included the suprapatellar pouch, suprapatella, patella, medial and lateral proximal recesses, medial and lateral trochlear ridges, trochlear groove. Structures identified in the distal aspect of the joint included the cranial and caudal cruciate ligaments, medial and lateral menisci, medial and lateral femoral condyles, the long digital extensor tendon, and the cranial meniscal ligaments were identified. All of the proximal structures could be seen in 16/20 limbs. Distally, the cranial cruciate ligament could be identified and manipulated most often (17/20 limbs), followed by the caudal cruciate ligament (11/20), the menisci (9/20), and condyles (9/20). The average examination time was 27 minutes. There was a variably present femorotibial membrane.ConclusionWe conclude that the arthoscopic evaluation of the stifle in rabbits is a viable surgical approach and could be used for rabbit models or to examine clinical cases with stifle pathology. Precise portal placement and adequate infrapatellar fat pad debridement were critical for success.
Exploring animal rabies endemicity to inform control programmes in Punjab, India
Authors: Brookes V. J. , Gill G. S. , Singh C. K. , Sandhu B. S. , Dhand N. K. , Singh B. B. , Gill J. P. S. , Ward M. P. 
Published: October 2017

SummaryPrevious studies estimate that one‐third of the annual global burden of rabies (~20,000 cases) occurs in India. Elimination of canine rabies is essential to reduce this burden. Surveillance of animal cases can assess both the risk to humans and the efficacy of control strategies. The objective of this study was to describe the spatial and temporal occurrence of reported confirmed cases of rabies in animals in Punjab, India, from 2004 to 2014. We analysed passive surveillance data on 556 samples submitted from 2004 to 2014 to GADVASU, Ludhiana, Punjab, India. Regression and time series analyses were conducted to understand seasonal and long‐term variation of cases and identify cross‐correlation of monthly cases between species. Spatio‐temporal analyses assessed spatial autocorrelation of date of reporting, mean geographic centres of disease occurrence and clustering of cases using Kulldorff's space‐time permutation statistic. The annual number of submissions and proportion of confirmed cases were consistent throughout 2004–2014. Most submissions (320; 57.6%) were confirmed rabies cases, including dogs (40.6%), buffalo (29.7%) and cattle (23.1%). Regression analysis of monthly cases in dogs showed seasonal variation with significant increases in cases in March and August. Monthly case numbers in buffalo decreased over time. Long‐term temporal trend was not detected in dog and cattle cases. Time‐series models identified significant cross‐correlation between dog and buffalo cases, suggesting that buffalo cases were spillover events from dogs. Significant spatio‐temporal variation or clusters of cases were not detected. These results indicate that rabies cases in animals—and therefore, the potential for exposure to humans—were temporally and spatially stable during 2004–2014 in Punjab, India. The endemic nature of rabies transmission in this region demands a coordinated, sustained control programme. This study provides baseline information for assessing the efficacy of rabies control measures and developing seasonally targeted dog vaccination and rabies awareness strategies.
Resonant parameters of Y(4390)
Authors: Zhang Jielei , Yuan Limin 
Published: October 2017

The cross-sections of [Formula: see text] and [Formula: see text] have been measured by BESIII experiment. A new resonance [Formula: see text] is observed in the two decay modes. A combined fit is performed to the two cross-sections. [Formula: see text]’s parameters are determined to be [Formula: see text], [Formula: see text], where the first uncertainties are statistical and the second systematic. The ratio [Formula: see text] is also obtained and it indicates that [Formula: see text]’s main decay modes maybe [Formula: see text]. We determine the lower limit of its leptonic decay width of around 150 eV, which can be compared with the theoretical expectations of different models. These information may help in understanding the nature of this state.
Exploring fundamental physics with gravitational waves
Authors: Kobakhidze Archil 
Published: October 2017

The direct discovery of gravitational waves opens of new avenues for exploring fundamental microscopic physics. In this presentation, a I will illustrate this by obtaining the stringent bounds on the scale of quantum fuzziness of hypothetical noncommutative space–time. I also discuss how future observations of stochastic gravitational wave background can shed light on the nature of the Higgs mechanism of the electroweak symmetry breaking and the related cosmological phase transition. a Based on a talk presented at the Conference on Cosmology, Gravitational Waves and Particles, NTU, Singapore, 6–10 February 2017.
Wind–Flux Feedbacks and Convective Organization during the November 2011 MJO Event in a High-Resolution Model
Authors: Riley Dellaripa Emily M. , Maloney Eric , van den Heever Susan C. 
Published: October 2017

The November 2011 Madden–Julian oscillation (MJO) event during the Dynamics of the MJO (DYNAMO) field campaign is simulated with the Regional Atmospheric Modeling System (RAMS) cloud-resolving model to examine the relationship between precipitation and surface latent heat flux (LHFLX) for deep convective clusters within the MJO and to discern the importance of surface LHFLX for organizing MJO convection. First, a simulation similar in size to the DYNAMO northern sounding array was run with interactive surface fluxes. Composites for precipitation, surface LHFLX, wind speed, wind vectors, and near-surface specific humidity are described for various-sized convective clusters during different MJO regimes. The precipitation–LHFLX relationship generally evolves as follows for an individual cluster. About 2 h before cluster identification, the maximum LHFLX occurs upwind of maximum precipitation. As cluster identification time is approached, LHFLX and precipitation maxima become coincident. At and after the cluster is identified, maximum LHFLXs move downwind of the precipitation maximum with a local minimum in LHFLXs behind the precipitation maximum.Sensitivity simulations with spatially homogenized LHFLXs were then run to determine the impacts of local LHFLX feedbacks on convective organization. Using area-averaged convective versus stratiform precipitation fraction and a simple convective aggregation index to quantify organization, no systematic difference in convective organization was detected between the control and sensitivity simulations, suggesting that local LHFLX variability is not important to convective organization in this model. Implications of these results are discussed.
Coupling of Wave Data and Underwater Acoustic Measurements in a Maritime High-Traffic Coastal Area: A Case Study in the Strait of Sicily
Authors: Raffa Francesco , Ludeno Giovanni , Buscaino Giuseppa , Sannino Gianmaria , Carillo Adriana , Grammauta Rosario , Spoto Domenico , Soldovieri Francesco , Mazzola Salvatore , Serafino Francesco 
Published: October 2017

AbstractUnderwater acoustic monitoring combined with real-time sea surface observations and numerical model forecasts could improve the efficiency of natural and anthropogenic sound source discrimination. In this work, acoustic sound pressure levels at different frequencies were compared with significant wave heights, measured using an X-band radar system, and then matched against independent data derived from a Simulating Waves Nearshore (SWAN) model in order to confirm their reliability. The acoustic data were recorded from a fixed buoy located in the Sicilian Channel at 4.9 km from the coast and 33 km from the X-band radar system installed at Cape San Marco (in the southwest region of Sicily). All data were acquired during two different periods: 28 February–16 March 2015 and 23 April–27 May 2015. The level of noise at the 16-Hz octave band showed the best linear correlation , with in situ radar observations of significant wave height. Radar measurements of wave height coupled with in situ acoustic measurements give a characterization of the level of noise as result of sea state in a specific area. These measurements could be used to discriminate natural sources of noise (waves) from other sound sources, such as biological and anthropogenic sources. This discrimination contributes to understanding the impact of acoustic pollution on marine environments and provides a monitoring plan protocol for safeguarding biodiversity in the Mediterranean coastal areas.
350 Euston Road: Improving building performances and carbon footprint with innovative heating, ventilation and air conditioning solutions – A case study
Authors: Draper Phil 
Published: October 2017

This case study paper describes the advantages of how heat pumps with heat recovery worked to contribute to improving energy performance and reducing the carbon footprint of buildings, with a short payback, thus showing it is a viable technology for energy cost reduction and for improving the environmental impact of buildings within the UK. All actions were taken based on performance for both the current and the future expected needs of the building and are measured against a baseline. The research and results confirm that heat pumps with heat recovery are a viable solution for London office buildings offering an integrated approach to building heating and cooling. The project resulted in a final reduction of 62% on the base building controlled utilities (total building less occupier power). The added benefits will be around the carbon benefits that the resultant 86% reduction in gas will bring due to the gradual de-carbonisation of the electric energy production in the UK. Practical application: This paper illustrates how to utilise an existing building’s energy use data to determine how relatively simple technology can optimise the provision of simultaneous heating and cooling for comfort. It also details how modelled data can be used to allow the correct sizing of equipment to deliver both good internal comfort and low carbon emissions.
Experimental evidence for weaker endogenous inhibition of trigeminal pain than extra-trigeminal pain in healthy individuals
Authors: Levy Dan , Abdian Lorin , Dekel-Steinkeller Michal , Defrin Ruth 
Published: October 2017

Background and objectives The prevalence of pain syndromes that affect the territories innervated by the trigeminal nerve, such as headaches, is one of the highest and ranks second only to low back pain. A potential mechanism underlying this high prevalence may be a relatively weak endogenous pain modulation of trigeminal pain. Here, we sought to systematically compare endogenous pain modulation capabilities in the trigeminal region to those of extra-trigeminal regions in healthy subjects. Methods Healthy, pain free subjects (n = 17) underwent a battery of quantitative sensory testing to assess endogenous pain inhibition and pain enhancement efficiencies within and outside the trigeminal innervated region. Measurements included conditioned pain modulation (CPM), temporal summation of pain (TSP) and spatial summation of pain (SSP). Results Testing configurations that included trigeminal-innervated body regions displayed significantly weaker CPM when compared to extra-trigeminal innervated areas. SSP magnitude was smaller in the ophthalmic trigeminal innervation when compared to other body regions. TSP magnitude was not different between the different body regions tested. Conclusions Our findings point to regional differences in endogenous pain inhibition and suggest that in otherwise healthy individuals, the trigeminal innervation is subjected to a weaker inhibitory pain control than other body regions. Such weaker endogenous pain control could play, at least in part, a role in mediating the high prevalence of trigeminal-related pain syndromes, including primary headaches and TMD pain.
What is ‘moral distress’? A narrative synthesis of the literature
Authors: Morley Georgina , Ives Jonathan , Bradbury-Jones Caroline , Irvine Fiona 
Published: October 2017

Aims: The aim of this narrative synthesis was to explore the necessary and sufficient conditions required to define moral distress. Background: Moral distress is said to occur when one has made a moral judgement but is unable to act upon it. However, problems with this narrow conception have led to multiple redefinitions in the empirical and conceptual literature. As a consequence, much of the research exploring moral distress has lacked conceptual clarity, complicating attempts to study the phenomenon. Design: Systematic literature review and narrative synthesis (November 2015–March 2016). Data sources: Ovid MEDLINE® In-Process & Other Non-Indexed Citations 1946–Present, PsycINFO® 1967–Present, CINAHL® Plus 1937–Present, EMBASE 1974–24 February 2016, British Nursing Index 1994–Present, Social Care Online, Social Policy and Practice Database (1890–Present), ERIC (EBSCO) 1966–Present and Education Abstracts. Review methods: Literature relating to moral distress was systematically retrieved and subjected to relevance assessment. Narrative synthesis was the overarching framework that guided quality assessment, data analysis and synthesis. Results: In all, 152 papers underwent initial data extraction and 34 were chosen for inclusion in the narrative synthesis based on both quality and relevance. Analysis revealed different proposed conditions for the occurrence of moral distress: moral judgement, psychological and physical effects, moral dilemmas, moral uncertainty, external and internal constraints and threats to moral integrity. Conclusion: We suggest the combination of (1) the experience of a moral event, (2) the experience of ‘psychological distress’ and (3) a direct causal relation between (1) and (2) together are necessary and sufficient conditions for moral distress.
The role of a composite polycarbonate-aerogel face shield in protecting the human brain from blast-induced injury: A fluid–structure interaction (FSI) study
Authors: Tse Kwong Ming , Bin Tan Long , Ali Bin Sapingi Mohamad , Franklyn Melanie , Lee Peter Vee Sin , Beng Chye Tan Vincent , Pueh Lee Heow 
Published: October 2017

Background Blast-induced traumatic brain injury is the most prevalent injury sustained by combat soldiers at the frontline. The current study aims to investigate the effectiveness of composite polycarbonate-aerogel face shields with different configurations in mitigating blast-induced brain injuries. Method A series of dynamic fluid–structure interaction simulations of a helmeted head subjected to a frontal free field blast was performed, to evaluate the effectiveness of the current conventional polycarbonate face shield and three other composite face shields with different configurations when exposed to a frontal free-field blast. Results The simulation results demonstrated that the sandwiched structured face shields of polycarbonate and aerogel provided superior blast attenuation than a single-layered polycarbonate face shield. The alternate multi-layered transparent materials of high and low densities provided the best attenuation of blast pressure transmission to the head, with the polycarbonate exterior shell casing contributing to the structural integrity of the face shield, while the lower dense aerogel filler providing high acoustic impedance to blast wave transmission. Conclusion This study provides further insights on future development and design of personal protective equipment in mitigating blast-induced injuries to the head.