bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reference tissue normalization in longitudinal 18F-florbetapir positron emission tomography of late mild cognitive impairment
Authors: Shokouhi Sepideh , Mckay John W. , Baker Suzanne L. , Kang Hakmook , Brill Aaron B. , Gwirtsman Harry E. , Riddle William R. , Claassen Daniel O. , Rogers Baxter P. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: January 2016

Abstract
Background
Semiquantitative methods such as the standardized uptake value ratio (SUVR) require normalization of the radiotracer activity to a reference tissue to monitor changes in the accumulation of amyloid-β (Aβ) plaques measured with positron emission tomography (PET). The objective of this study was to evaluate the effect of reference tissue normalization in a test–retest 18F-florbetapir SUVR study using cerebellar gray matter, white matter (two different segmentation masks), brainstem, and corpus callosum as reference regions.

Methods
We calculated the correlation between 18F-florbetapir PET and concurrent cerebrospinal fluid (CSF) Aβ1–42 levels in a late mild cognitive impairment cohort with longitudinal PET and CSF data over the course of 2 years. In addition to conventional SUVR analysis using mean and median values of normalized brain radiotracer activity, we investigated a new image analysis technique—the weighted two-point correlation function (wS2)—to capture potentially more subtle changes in Aβ-PET data.

Results
Compared with the SUVRs normalized to cerebellar gray matter, all cerebral-to-white matter normalization schemes resulted in a higher inverse correlation between PET and CSF Aβ1–42, while the brainstem normalization gave the best results (high and most stable correlation). Compared with the SUVR mean and median values, the wS2 values were associated with the lowest coefficient of variation and highest inverse correlation to CSF Aβ1–42 levels across all time points and reference regions, including the cerebellar gray matter.

Conclusions
The selection of reference tissue for normalization and the choice of image analysis method can affect changes in cortical 18F-florbetapir uptake in longitudinal studies.
Structural and functional dissection of Toxoplasma gondii armadillo repeats only protein
Authors: Mueller Christina , Samoo Atta , Hammoudi Pierre-Mehdi , Klages Natacha , Kallio Juha Pekka , Kursula Inari , Soldati-Favre Dominique 
Published: January 2016

ABSTRACT
Rhoptries are club-shaped, regulated secretory organelles that cluster at the apical pole of apicomplexan parasites. Their discharge is essential for invasion and the establishment of an intracellular lifestyle. Little is known about rhoptry biogenesis and recycling during parasite division. In Toxoplasma gondii, positioning of rhoptries involves the armadillo repeats only protein (ARO) and myosin F (MyoF). Here, we show that two ARO partners, ARO-interacting protein (AIP) and adenylate cyclase β (ACβ) localize to a rhoptry subcompartment. In absence of AIP, ACβ disappears from the rhoptries. By assessing the contribution of each ARO armadillo (ARM) repeat, we provide evidence that ARO is multifunctional, participating not only in positioning but also in clustering of rhoptries. Structural analyses show that ARO resembles the myosin-binding domain of the Caenorhabditis elegans myosin chaperone UNC-45. A conserved patch of aromatic and acidic residues denotes the putative MyoF-binding site, and the overall arrangement of the ARM repeats explains the dramatic consequences of deleting each of them. Finally, Plasmodium falciparum ARO functionally complements ARO depletion and interacts with the same partners, highlighting the conservation of rhoptry biogenesis in Apicomplexa.
MBD3L2 promotes Tet2 enzymatic activity for mediating 5-methylcytosine oxidation
Authors: Peng Lina , Li Yan , Xi Yanping , Li Wei , Li Jin , Lv Ruitu , Zhang Lei , Zou Qingping , Dong Shihua , Luo Huaibing , Wu Feizhen , Yu Wenqiang 
Published: January 2016

ABSTRACT
Ten-eleven translocation (Tet) proteins are key players involved in the dynamic regulation of cytosine methylation and demethylation. Inactivating mutations of Tet2 are frequently found in human malignancies, highlighting the essential role of Tet2 in cellular transformation. However, the factors that control Tet enzymatic activity remain largely unknown. Here, we found that methyl-CpG-binding domain protein 3 (MBD3) and its homolog MBD3-like 2 (MBD3L2) can specifically modulate the enzymatic activity of Tet2 protein, but not Tet1 and Tet3 proteins, in converting 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). Moreover, MBD3L2 is more effective than MBD3 in promoting Tet2 enzymatic activity through strengthening the binding affinity between Tet2 and the methylated DNA target. Further analysis revealed pronounced decreases in 5mC levels at MBD3L2 and Tet2 co-occupied genomic regions, most of which are promoter elements associated with either cancer-related genes or genes involved in the regulation of cellular metabolic processes. Our data add new insights into the regulation of Tet2 activity by MBD3 and MBD3L2, and into how that affects Tet2-mediated modulation of its target genes in cancer development. Thus, they have important applications in understanding how dysregulation of Tet2 might contribute to human malignancy.
α-Dystrobrevin-1 recruits Grb2 and α-catulin to organize neurotransmitter receptors at the neuromuscular junction
Authors: Gingras Jacinthe , Gawor Marta , Bernadzki Krzysztof M. , Grady R. Mark , Hallock Peter , Glass David J. , Sanes Joshua R. , Proszynski Tomasz J. 
Published: January 2016

ABSTRACT
Neuromuscular junctions (NMJs), the synapses made by motor neurons on muscle fibers, form during embryonic development but undergo substantial remodeling postnatally. Several lines of evidence suggest that α-dystrobrevin, a component of the dystrophin-associated glycoprotein complex (DGC), is a crucial regulator of the remodeling process and that tyrosine phosphorylation of one isoform, α-dystrobrevin-1, is required for its function at synapses. We identified a functionally important phosphorylation site on α-dystrobrevin-1, generated phosphorylation-specific antibodies to it and used them to demonstrate dramatic increases in phosphorylation during the remodeling period, as well as in nerve-dependent regulation in adults. We then identified proteins that bind to this site in a phosphorylation-dependent manner and others that bind to α-dystrobrevin-1 in a phosphorylation-independent manner. They include multiple members of the DGC, as well as α-catulin, liprin-α1, Usp9x, PI3K, Arhgef5 and Grb2. Finally, we show that two interactors, α-catulin (phosphorylation independent) and Grb2 (phosphorylation dependent) are localized to NMJs in vivo, and that they are required for proper organization of neurotransmitter receptors on myotubes.
Indicadores de desempenho em pequenas e médias empresas
Authors: Souza Antonia Egidia , Correa Hamilton Luiz 
Published: January 2016

As PMEs têm características organizacionais e de desempenho que as tornam diferentes das grandes empresas, porém nao se pode negligenciar o importante papel dos sistemas de mensuração de desempenho para qualquer tipo de empresa ou forma de gestão. Com isso em mente, a intenção deste artigo foi responder a duas perguntas importantes: as Pequenas e Médias Empresas (PMEs) empregam indicadores de mensuração de desempenho? As características organizacionais influenciam no emprego de indicadores de mensuração de desempenho? Para melhor responder essas questões aplicou-se uma pesquisa de campo com uma amostra não probabilística por conveniência com 87 empresas do setor calçadista de Santa Catarina. O método privilegiado foi o quantitativo e na análise dos dados aplicou-se técnicas estatisticas com o auxílio do SPSS. Os resultados revelam que as empresas pesquisadas adotam indicadores financeiros e não financeiros, porém os indicadores financeiros são mais utilizados que os não financeiros.
Recording inpatient weight: implications for medicines administration
Authors: Willson Jamie SB , Thomas Seb J , Mackenzie Strachan C , Armitage Alice J , Sen Soumen , Ratliff William D , Patel Arti , Black Sabrina E , Chauhan Sarasvati U , Robb Alastair O , Garnham Kathryn E , Horsnell Jonathan D , Tarr Gregory P 
Published: January 2016

Aim:To identify the proportions of hospital inpatients with recorded weights: among all patients, and among those receiving weight-dosed drug therapy.Method:Survey of clinical notes of hospital inpatients across a convenience sample of 11 secondary and tertiary referral hospitals in England and Wales in November 2011.Results:1068 patients were included, and 1061 patient clinical notes were available (99.3%). Nearly all paediatric patients had recorded weights (77/78; 98.7%). Half of adult inpatients had recorded weights (503/983, 51.2%). The proportion of adult inpatients with recorded weights varied by hospital, ranging from 13.5% to 92.5% (p<0.0001). In those receiving gentamicin or therapeutic-dose low molecular weight heparin (t-LMWH), only 64.5% (71/110) had a recorded weight.Conclusions:Half of adult inpatients, and two-thirds of those receiving gentamicin or t-LMWH, had recorded weights. There was significant variation in rates of weighing adult inpatients across hospitals. This may put patients at increased risk of side effects and problems resulting from malnutrition.
The moon as my witness
Authors: Allen Jess , Preece Bronwyn 
Published: January 2016

Abstract
full:new was a transnational score for a site-based Authentic Movement (AM) and ecopoetic writing practice, performed for the duration of a complete lunar phase: two women (one in Wales, the other in Canada) moving/writing authentically on their respective sites for 28 minutes every day, for 28 consecutive days. The process led to the creation of a collaborative, concrete poem: the length of each line waxing and waning daily with the moon. In an adaptation of the ‘classic’ form of AM, the moverwitness dyad was stretched into a virtual arc across the northern hemisphere, held within the witnessing circle of the moon’s cycle: ‘witnessing’ thus took the form of a remote, reciprocal commitment to self, site and other, through a strict adherence to the score. In these artist pages, we offer a reflective poetic-photographic documentation of this practice, with an accompanying written commentary on the role of AM within this process: how can the authentically moving body, transnationally witnessed, become a resonant organ both for sensing ecological relations and writing them into being?
Choice, surrender and transitions in Authentic Movement: Reflections on personal and teaching practice
Authors: Hartley Linda 
Published: January 2016

Abstract
I was first introduced to Authentic Movement in 1980, and since that time it has been central to my personal practice. I have integrated it into my training programme in Integrative Bodywork & Movement Therapy1 since its inception in 1990, and began to teach the Discipline of Authentic Movement in 2000, inspired by my studies with Janet Adler. Authentic Movement has also profoundly informed my practice as a somatic movement therapist and transpersonal psychotherapist over a period of 30 years.
Holy dreaming – poetry and movement
Authors: Mahon Siobhan Mac 
Published: January 2016

Abstract
This artist’s document incorporates my poetry and the relationship between it and my ongoing practice in Authentic Movement. Both these practices are an embodied expression of a journey towards the truth of my own body; this ‘truth’ wraps herself within the words of a poem or expresses herself through the body. I explore the sacred nature of a collective participation in the unfolding of a new, healing story for the Earth.
Journey of the inner witness: A path of development
Authors: Sager Paula 
Published: January 2016

Abstract
This article discusses how a conscious interpersonal and intrapersonal relationship to movement impulse, as an expression of creative self-emergence, serves transformative growth. It offers an overview of Janet Adler’s developmental perspective on and teaching of the Discipline of Authentic Movement. The author’s research, looking at the development of the inner witness in practitioners of Authentic Movement over a 30-year span of time, affirms and offers new insights into Adler’s model of a threephase development of human consciousness. The article also demonstrates how the research process itself integrates contemplative inquiry into an academic study, and notes the parallels between the practice of witness consciousness and the practice of phenomenological research.
Particle Image Velocimetry and Proper Orthogonal Decomposition Applied to Aerodynamic Sound Source Region Visualization in Organ Flue Pipe
Authors: Mickiewicz Witold 
Published: January 2016

AbstractThe paper presents experimental results of the visualization of the nonlinear aeroacoustic sound generation phenomena occurring in organ flue pipe. The phase-locked particle image velocimetry technique is applied to visualize the mixed velocity field in the transparent organ flue pipe model made from Plexiglas. Presented measurements were done using synchronization to the tone generated by the pipe itself sup- plied by controlled air flow with seeding particles. The time series of raw velocity field distribution images show nonlinear sound generation mechanisms: the large amplitude of deflection of the mean flue jet and vortex shedding in the region of pipe mouth. Proper Orthogonal Decomposition (POD) was then applied to the experimental data to separately visualize the mean mass flow, pulsating jet mass flow with vortices and also sound waves near the generation region as well as inside and outside of the pipe. The resulting POD spatial and temporal modes were used to approximate the acoustic velocity field behaviour at the pipe fundamental frequency. The temporal modes shapes are in a good agreement with the microphone pressure signal shape registered from a distance. Obtained decomposed spatial modes give interesting insight into sound generating region of the organ pipe and the transition area towards the pure acoustic field inside the resonance pipe. They can give qualitative and quantitative data to verify existing sound generation models used in Computational Fluid Dynamics (CFD) and Computational Aero-Acoustics (CAA).
“Journeys are Meaningful” (Travelling, Travellers, Literary Periods, Literary Journeys)
Authors: Fried István 
Published: January 2016

Abstract
If the changes of the “discourse networks” (Aufschreibesysteme) from 1800 to 1900 model the relations pertaining to the personality, to the cultural determinedness of technology and personality as well as to their interconnections (Kittler 1995), especially having in view the literary mise en scène, it applies all the more to travelling - setting out on a journey, heading towards a destination, pilgrimage and/or wandering as well as the relationship between transport technology and personality. The changes taking place in “transport” are partly of technological, partly (in close connection with the former) indicative of individual and collective claims. The diplomatic, religious, commercial and educational journeys essentially belong to the continuous processes of European centuries; however, the appearance of the railway starts a new era at least to the same extent as the car and the airplane in the twentieth century. The journeys becoming systematic and perhaps most tightly connected to pilgrimages from the Middle Ages on assured the “transfer” of ideas, attitudes and cultural materials in the widest sense; the journeys and personal encounters (of course, taking place, in part, through correspondence) of the more cultured layers mainly, are to be highly appreciated from the viewpoint of the history of mentalities and society.
Piso the Rambler: Travelling and Tracking in Cicero’s Rhetoric Discourse
Authors: Pap Levente 
Published: January 2016

Abstract
Travelling was not less popular in ancient times than nowadays. People would set out for distant lands with various purposes: to trade, to do business, to gain information, to further develop science, to fight a battle, to visit sacred sites, and last but not least, they travelled with political-administrative purposes. Those who returned from these voyages often shared their exotic experiences; sometimes they even put them down on paper (like Herodotus, Pausanias, Caesar, etc.]. When somebody’s journey or delegation had not been very successful, they could still cosmeticize the story when telling it in the City, in case there had not been any witnesses to tell otherwise. On the other hand, such cases could easily be exploited by the prosecutor in critical situations such as a trial: Cicero used this exact method in his attack against Piso.
A Melancholy Journey through Landscapes of Transience
Authors: Pieldner Judit 
Published: January 2016

Abstract
Saturn is the planet of melancholy, about which Walter Benjamin writes: “I came into the world under the sign of Saturn - the star of the slowest revolution, the planet of detours and delays.” W. G. Sebald’s prose poetics seems to be driven by this motion, which is more than a simple state of being: it is a way of perceiving the world as well as a way of writing, perpetual transition, walk, halt, deviation from the road, getting lost and finding the way back. The paper reflects on W. G. Sebald’s The Rings of Saturn (Die Ringe des Saturn: Eine englische Wallfahrt, 1995], a unique literary achievement deeply embedded into the history of literature, culture and the arts, which can be best construed from the direction of “the order of melancholy.” On the pages of the book the reader can traverse, together with the Sebald-narrator, a route in East Anglia, with digressions in various directions of (culture) history. The journey in the concrete physical space turns into an inner journey, into a spiritual pilgrimage; the traversed locations become documents of destruction and transience. From the perspective of the order of melancholy places are determined by their relations, temporality and role in history rather than by their concrete geographic coordinates. The infinitely rich construction of the narrative creates a continuous passage between the local and the universal, the concrete locations of the journey and the scenes of world history, between the time of the journey and the (colonial] past, between East and West. The traversed historical, cultural and medial spaces displace the perception of human existence and result in the incommensurable aesthetic experience of the Sebaldian prose.
Change of Place, Space Perception and Topographic Discourse
Authors: Toldi Éva 
Published: January 2016

Abstract
The paper examines the view and representation of space in Terézia Mora’s prose, primarily based on her novel entitled The Only Man on the Continent (Der einzige Mann auf dem Kontinent). In the universe of the novel the perception of space basically determines the individual’s space of action and highly influences his self-image as well as his attitude toward alterity. The city not only functions as space, but also forms a multicultural medium which becomes itself the subject of reflection and metanarration. In the novel the anthropological places and non-places, in Augé’s sense, change their function and thus the borders of referential, mental and virtual worlds are blurred, the notion of space itself is revaluated. The protagonist is the Ulysses of our days; his journeys and adventures mainly take place in his imagination. In the virtual world he loses his sense of reality, which can also be perceived in the narrative procedures of the text: the novel is in fact the protagonist’s quest for identity, his endless monologue, which is interrupted by the omniscient narrator’s comments from time to time. In the meantime the evident intertextual context also gets shape: the text maintains an ironical intertextual connection with James Joyce’s Ulysses.
Phonetic Adaptation of Hungarian Loanwords in Romanian
Authors: Both Csaba Attila 
Published: January 2016

Abstract
In current linguistics, as well as in the fields of contact linguistics and sociolinguistics, the assessment of contact between the different languages used by speakers living in the same geographical/political area receives a pronounced role. These languages inevitably come into contact. The research on language contact between Hungarian and Romanian has a past marked by scholarly works that focus especially on the lexical- semantic level. Because contact between linguistic phenomena occurs at every level of language, it is necessary to focus on the smallest linguistic elements as well. In our work, we analyse a corpus of words borrowed from Hungarian by the Romanian language, focusing on stop sounds. In our paper, we establish the main phonetic transfer modalities, discussing the subject in an international framework.
Modelling of chemical migration under the overlapping impact of multiple and diverse pollution sources in the area of the “Zachem” Chemical Plant (Bydgoszcz, northern Poland)
Authors: Pietrucin Dorota , Czop Mariusz 
Published: January 2016

Abstract
Modelling studies of chemical migration in the area of the “Zachem” Chemical Plant in Bydgoszcz started from the analyses of the production profile. These studies were conducted to investigate the potential contamination. Organic compounds still represent a substantial concentration in the soil and water environment, including total organic carbon (TOC) reaching values above 1600 mg/L, aniline, nitrobenzene and phenol (up to 500-800 mg/l), organochloride and organometallic compounds, as well as hydrocarbons, such as benzene, toluene and PAHs. Groundwater contains most of the major ions (chlorides, sulphates and bicarbonates, sodium and calcium) and trace elements (Al, Co, Cr and Ni).
A reliable conceptual model of the geological structure was constructed for 3 continuous layers with variable bottom morphology. This model represents the complex structure containing permeable and impermeable Quaternary and Neogene deposits. A hydrogeological numerical model was created for the area of the “Zachem” Chemical Plant using the Visual MODFLOW program. Low values of two key statistical measures confirm a good model fit to the measured data: root mean square (RMS) amounts to only about 1.5 m and normalized RMS reaches only about 4.4%. The differences between measured and calculated values are normally distributed. A Modpath module was used to analyse the potential extent of contaminant plume. Accurate hydrogeological 3D sampling was conducted using a “low flow” technique.
The results of full and reliable modelling of the chemical migration under the overlapping impact of multiple and diverse pollution sources in the area of the “Zachem” Chemical Plant are essential for further planning of remedial strategies.
Non-invasive diagnostic methods for investigating the quality of Žilina airport’s runway
Authors: Slabej Martin , Grinč Michal , Kováč Matúš , Decký Martin , Šedivý Štefan 
Published: January 2016

Abstract
The Žilina airport was after almost 50 years of use measured by non-invasive methods including GPR and Profilograph GE in order to investigate the quality of the runway pavement at the chosen spots. Since it was just a pilot action, a sample of survey was carried out. The testing spots were placed where the geologic drill core J02 have been drilled out. The measurements performed by Profilograph GE were used to verify the quality of the pavement surface in term longitudinal unevenness by means of index IRI and C. The GPR survey was performed in 3D geometry, hence in the x- and y-direction. A horn type antenna with central frequency of 2 GHz was used on the test field in order to verify the thicknesses of pavement construction layers. Here, the result of a 3D survey is presented. The investigation confirms two sub-horizontal construction layers of the runway pavement. In some areas the GPR interpretation was not possible due to the signal attenuation. This significant signal attenuation is found mainly in the areas where the linear cracks are situated.