bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcatheter Tricuspid Valve-in-Valve Implantation for the Treatment of Dysfunctional Surgical Bioprosthetic Valves
Authors: McElhinney Doff B. , Cabalka Allison K. , Aboulhosn Jamil A. , Eicken Andreas , Boudjemline Younes , Schubert Stephan , Himbert Dominique , Asnes Jeremy D. , Salizzoni Stefano , Bocks Martin L. , Cheatham John P. , Momenah Tarek S. , Kim Dennis W. , Schranz Dietmar , Meadows Jeffery , Thomson John D.R. , Goldstein Bryan H. , Crittendon Ivory , Fagan Thomas E. , Webb John G. , Horlick Eric , Delaney Jeffrey W. , Jones Thomas K. , Shahanavaz Shabana , Moretti Carolina , Hainstock Michael R. , Kenny Damien P. , Berger Felix , Rihal Charanjit S. , Dvir Danny 
Published: March 2016

Background—
Off-label use of transcatheter aortic and pulmonary valve prostheses for tricuspid valve-in-valve implantation (TVIV) within dysfunctional surgical tricuspid valve (TV) bioprostheses has been described in small reports.

Methods and Results—

An international, multicenter registry was developed to collect data on TVIV cases. Patient-related factors, procedural details and outcomes, and follow-up data were analyzed. Valve-in-ring or heterotopic TV implantation procedures were not included. Data were collected on 156 patients with bioprosthetic TV dysfunction who underwent catheterization with planned TVIV. The median age was 40 years, and 71% of patients were in New York Heart Association class III or IV. Among 152 patients in whom TVIV was attempted with a Melody (n=94) or Sapien (n=58) valve, implantation was successful in 150, with few serious complications. After TVIV, both the TV inflow gradient and tricuspid regurgitation grade improved significantly. During follow-up (median, 13.3 months), 22 patients died, 5 within 30 days; all 22 patients were in New York Heart Association class III or IV, and 9 were hospitalized before TVIV. There were 10 TV reinterventions, and 3 other patients had significant recurrent TV dysfunction. At follow-up, 77% of patients were in New York Heart Association class I or II (
P
<0.001 versus before TVIV). Outcomes did not differ according to surgical valve size or TVIV valve type.

Conclusions—
TVIV with commercially available transcatheter prostheses is technically and clinically successful in patients of various ages across a wide range of valve size. Although preimplantation clinical status was associated with outcome, many patients in New York Heart Association class III or IV at baseline improved. TVIV should be considered a viable option for treatment of failing TV bioprostheses.
Calcitonin gene-related peptide induced migraine attacks in patients with and without familial aggregation of migraine
Authors: Guo Song , Christensen Anne Francke , Liu Marie Louise , Janjooa Benjamin Naveed , Olesen Jes , Ashina Messoud 
Published: March 2016

Background Calcitonin gene-related peptide provokes migraine attacks in 65% of patients with migraine without aura. Whether aggregation of migraine in first-degree relatives (family load) or a high number of risk-conferring single nucleotide polymorphisms contributes to migraine susceptibility to calcitonin gene-related peptide infusion in migraine patients is unknown. We hypothesized that genetic enrichment plays a role in triggering of migraine and, therefore, migraine without aura patients with high family load would report more migraine attacks after calcitonin gene-related peptide infusion than patients with low family load. Methods We allocated 40 previously genotyped migraine without aura patients to receive intravenous infusion of 1.5 µg/min calcitonin gene-related peptide and recorded migraine attacks including headache characteristics and associated symptoms. Information of familial aggregation was obtained by telephone interview of first-degree relatives using a validated semi-structured questionnaire. Results Calcitonin gene-related peptide infusion induced a migraine-like attack in 75% (12 out of 16) of patients with high family load compared to 52% (12 out of 23) with low family load ( P = 0.150). In addition, we found that the migraine response after calcitonin gene-related peptide was not associated with specific or a high number of risk-conferring single nucleotide polymorphisms of migraine without aura. Conclusion We found no statistical association between familial aggregation of migraine and hypersensitivity to calcitonin gene-related peptide infusion in migraine without aura patients. We also demonstrated that the currently known single nucleotide polymorphisms conferring risk of migraine without aura have no additive effect on calcitonin gene-related peptide induced migraine-like attacks.
Part I: Pituitary adenylate cyclase-activating polypeptide-38 induced migraine-like attacks in patients with and without familial aggregation of migraine
Authors: Guo Song , Vollesen Anne Luise Haulund , Hansen Rikke Dyhr , Esserlind Ann-Louise , Amin Faisal Mohammed , Christensen Anne Francke , Olesen Jes , Ashina Messoud 
Published: March 2016

Background Intravenous infusion of adenylate cyclase-activating polypeptide-38 (PACAP38) provokes migraine-like attacks in 65–70% of migraine sufferers. Whether aggregation of migraine in first-degree relatives contributes to this discrepancy in PACAP38-induced response is unknown. We hypothesized that genetic enrichment plays a role in triggering of migraine and that migraine without aura patients with a high family load ( ≥ 2 first-degree relatives with migraine) would report more migraine-like attacks after intravenous infusion of human PACAP38. Methods In this study, we allocated 32 previously genotyped migraine without aura patients to receive intravenous infusion of 10 pmol/kg/min PACAP38 and recorded migraine-like attacks including headache characteristics and associated symptoms. Information of familial aggregation was obtained by telephone interview of first-degree relatives using a validated semi-structured questionnaire. Results PACAP38 infusion induced a migraine-like attack in 75% (nine out of 12) of patients with high family load compared to 70% (14 out of 20) with low family load ( P = 0.761). In an explorative investigation, we found that the migraine response after PACAP38 was not associated with the risk allele of rs2274316 ( MEF2D), which confers increased risk of migraine without aura and may regulate PACAP38 expression. Conclusion Migraine response to PACAP38 infusion in migraine without aura patients is not associated with high family load or the risk allele of rs2274316 ( MEF2D).
The Utilization of Antithrombotic Therapy in Older Australians With Atrial Fibrillation
Authors: Frain Bridget Elise , Castelino Ronald , Bereznicki Luke 
Published: March 2016

What is known and Objective: Oral anticoagulants are essential drugs for the prevention of thromboembolic events in patients with atrial fibrillation (AF). Anticoagulants are, however, commonly withheld due to a perceived risk of severe adverse events. The underutilization of anticoagulants in patients with AF has been demonstrated internationally, but to date, there are limited data available in the Australian context. The aim of this study was to determine the utilization patterns of anticoagulants (including novel oral anticoagulants) with respect to stroke and bleeding risk among patients with AF within the community. Methods: We performed a nonexperimental, retrospective analysis designed to evaluate antithrombotic usage for AF in Australia. The utilization of antithrombotic therapy and the appropriateness of therapy were determined based on CHADS2, CHA2DS2-VASc and HAS-BLED risk stratification schemes. The presence of documented contraindications was used to determine the appropriateness of antithrombotic therapy. What is new and Conclusion: Anticoagulants were overutilized in patients at low risk of stroke and underutilized in patients at higher risk of stroke. As the HAS-BLED score increased, the likelihood of patients receiving an anticoagulant decreased regardless of CHADS2 or CHA2DS2-VASc scores.
The association between socioeconomic status and the symptoms at diagnosis of celiac disease: a retrospective cohort study
Authors: Roy Abhik , Mehra Shilpa , Kelly Ciarán P. , Tariq Sohaib , Pallav Kumar , Dennis Melinda , Peer Ann , Lebwohl Benjamin , Green Peter H. R. , Leffler Daniel A. 
Published: March 2016

Background: There are little data on patient factors that impact diagnosis rates of celiac disease. This study aims to evaluate the association between patient socioeconomic status and the symptoms at diagnosis of celiac disease. Methods: A total of 872 patients with biopsy-proven celiac disease were categorized based on the presence or absence of (1) diarrhea and (2) any gastrointestinal symptoms at diagnosis. Univariate and multivariate analyses were used to assess the association between socioeconomic status and symptoms. Results: Patients without diarrhea at presentation had a higher mean per capita income (US$34,469 versus US$32,237, p = 0.02), and patients without any gastrointestinal symptoms had a higher mean per capita income (US$36,738 versus US$31,758, p < 0.01) compared with patients having such symptoms. On multivariable analysis adjusting for sex, age, autoimmune or psychiatric comorbidities, and income, per capita income remained a significant predictor of diagnosis without gastrointestinal symptoms (odds ratio: 1.71, 95% confidence interval: 1.17–2.50, p < 0.01), and it showed a trend towards significance in diagnosis without diarrhea (odds ratio: 1.40, 95% confidence interval: 0.98–2.02, p = 0.06). Conclusions: Patients with nonclassical symptoms of celiac disease are less likely to be diagnosed if they are of lower socioeconomic status. Celiac disease may be under-recognized in this population due to socioeconomic factors that possibly include lower rates of health-seeking behavior and access to healthcare.
Preclinical models of acute and chronic graft-versus-host disease: how predictive are they for a successful clinical translation?
Authors: Zeiser Robert , Blazar Bruce R. 
Published: March 2016

AbstractDespite major advances in recent years, graft-versus-host disease (GVHD) remains a major life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT). To improve our therapeutic armory against GVHD, preclinical evidence is most frequently generated in mouse and large animal models of GVHD. However, because every model has shortcomings, it is important to understand how predictive the different models are and why certain findings in these models could not be translated into the clinic. Weaknesses of the animal GVHD models include the irradiation only-based conditioning regimen, the homogenous donor/recipient genetics in mice, canine or non-human primates (NHP), anatomic site of T cells used for transfer in mice, the homogenous microbial environment in mice housed under specific pathogen-free conditions, and the lack of pharmacologic GVHD prevention in control groups. Despite these major differences toward clinical allo-HCT, findings generated in animal models of GVHD have led to the current gold standards for GVHD prophylaxis and therapy. The homogenous nature of the preclinical models allows for reproducibility, which is key for the characterization of the role of a new cytokine, chemokine, transcription factor, microRNA, kinase, or immune cell population in the context of GVHD. Therefore, when carefully balancing reasons to apply small and large animal models, it becomes evident that they are valuable tools to generate preclinical hypotheses, which then have to be rigorously evaluated in the clinical setting. In this study, we discuss several clinical approaches that were motivated by preclinical evidence, novel NHP models and their advantages, and highlight the recent advances in understanding the pathophysiology of GVHD.
Center of mass velocity based predictions in balance recovery following pelvis perturbations during human walking
Authors: Vlutters M. , Van Asseldonk E.H.F. , Van der Kooij H. 
Published: March 2016

In many simple walking models foot placement dictates the center of pressure location and ground reaction force components, whereas humans can modulate these aspects after foot contact. Because of the differences, it is unclear to what extend predictions made by models are valid for human walking. Yet, both model simulations and human experimental data have previously indicated that the center of mass (COM) velocity plays an important role in regulating stable walking.
Here, perturbed human walking was studied for the relation of the horizontal COM velocity at heel strike and toe-off with the foot placement location relative to the COM, the forthcoming center of pressure location relative to the COM, and the ground reaction forces. Ten healthy subjects received various magnitude mediolateral and anteroposterior pelvis perturbations at toe-off, during 0.63 and 1.25 m s−1 treadmill walking.
At heel strike after the perturbation, recovery from mediolateral perturbations involved mediolateral foot placement adjustments proportional to the mediolateral COM velocity. In contrast, for anteroposterior perturbations no significant anteroposterior foot placement adjustment occurred at this heel strike. However, in both directions the COM velocity at heel strike related linearly to the center of pressure location at the subsequent toe-off. This relation was affected by the walking speed and was, for the slow speed, in line with a COM velocity based control strategy previously applied by others in a linear inverted pendulum model. Finally, changes in gait phase durations suggest that the timing of actions could play an important role during the perturbation recovery.
Quality assurance in the analysis of growth hormone and insulin-like growth factor I in disorders of the somatotropic axis
Authors: Bidlingmaier Martin , Hauffa Berthold P. , Trainer Peter J. , Etzrodt-Walter Gwendolin , Sauer Joachim , Kratzsch Jürgen , Petersenn Stephan , Ranke Michael B. , Wallaschofski Henri , Strasburger Christian J. 
Published: March 2016

Abstract

Background: Reliable laboratory analysis is fundamental to diagnostics, therapy, and follow-up of growth disturbance and secretory dysfunction of growth hormone (GH) and insulin-like growth factor I (IGF-I). Currently available commercial assays have their limitations, as they show large variations in hormone concentrations measured.

Methods: The recommendations of an expert workshop with practicing endocrinologists from the fields of pediatrics and internal medicine and with laboratory physicians, with reference to the outcome of the interdisciplinary consensus conference in Keswick (Virginia, USA) in 2009, were used.

Results: Among the quality criteria stipulated by the workshop participants are the use of uniform reference standards, documentation of analytical conditions (such as calibrators, binding epitopes, cross-reactivity, and methods for removal from the binding protein), batch-to-batch consistency, and low inter-assay variability. The participants recommended developing assay-specific thresholds and reference intervals based on large and well-defined reference populations. It is furthermore recommended to delineate the assay quality, particularly with reference to clinically important cutoffs.

Conclusions: The manufacturers of diagnostic assays should be obliged to regularly monitor and report the implementation of quality criteria. Only assays that are evaluated according to uniform quality standards and that are employed clinically permit informed diagnostic and therapy of patients with GH secretory dysfunction, preventing avoidable burden on both patients and paying authorities.
Masters Degree In Management Information Systems With A Supply Chain Management Focus
Authors: Ramaswamy Kizhanatham V. , Boyd Joseph L. , Desai Mayur 
Published: March 2016

A graduate curriculum in Management Information Systems with a Supply Chain Management focus is presented. The motivation for this endeavor stems from the fact that the global scope of modern business organizations and the competitive environment in which they operate, requires an information system leveraged supply chain management system (SCM) to ensure the efficient delivery of the right product, at the right place, at the right time, in the right quantity, and at a competitive price to the customer.
Public Rates Of Return On Higher Education Investments, By State
Authors: Courtright Stephen H. , Fry Cary G. 
Published: March 2016

Public rates of return on higher education expenditures are calculated by state. Benefits accruing to states from their investments in higher education are measured by differential tax revenues collected from college-educated citizens versus high-school-educated citizens. For most states we find an adequate rate of return on such investments. However, we conclude that in addition to monetary returns, state governments likely consider other factors when deciding upon expending resources for higher education needs.
A Confucian Framework For Categorizing Elementary Pre-service Teachers Expectations Of Their Science Methods Course
Authors: Hechter Richard P. , McGregor Lynette D. 
Published: March 2016

Science teacher educators strive to improve their elementary science methods courses through modification of existing content, activities, or teaching technique. But what do the enrolled preservice teachers expect to learn from these courses and how do they expect to learn it? This study qualitatively examines preservice elementary teachers’ expectations of: their science methods course, the activities of the course, the instructor, and of themselves. Upon entry to the elementary science methods course at two Midwestern colleges in the Fall term of 2008, preservice teachers (n=37) were asked to articulate what they expected to learn and how they expected to learn it. Their written responses were coded and categorized into one of three areas: imitation, reflection, and experience. These three categories, as a philosophical theoretical framework, stem from Confucius who suggested that the aforementioned areas were the keys to gaining wisdom. It is important, that as science teacher educators, we understand how our students expect to gain wisdom about their profession from our course. It is our contention that preservice teachers' expectations of their elementary science methods course prior to the commencement of the course have far reaching effects into the context in which they engage within the course.
arvis Existential Learning Model: Making It Work
Authors: Bergsteiner Harald , Avery Gayle C. 
Published: March 2016

Although it is widely recognized that individuals learn in different ways, there is some disagreement on the paths learners take. Responding to Kolb’s (1984) Experiential Learning Model, Jarvis proposed an Existential Learning Model to identify multiple routes that learners use. Examining Jarvis’ model critically reveals some problems: the model does not reflect either its supporting text or sound modeling practices and conventions, is subject to an error in discourse, and fails to depict the specific learning routes that Jarvis’ own research identified. This paper develops Jarvis’ model to align it with the theory, clearly depicts learning routes, and proposes a more logical and effective model that aligns with modeling theorists’ criteria.
The Traditional Non-Traditional Landscape Architecture Studio: Education Through Service Learning In Miami, OK
Authors: Loon Leehu 
Published: March 2016

This research will illustrate the importance of a recent service learning project that was conducted for Miami, Oklahoma, by landscape architecture graduate students and faculty of the University of Oklahoma. Students and faculty partnered with the community to form the studio design team. Education in the landscape architecture studio at the graduate level provides an excellent opportunity to engage communities through service learning projects. Service learning is a unique, dynamic, and powerful framework for student learning and landscape architecture is a diverse profession which requires a multi-faceted educational approach, including community based outreach projects. Miami, Oklahoma, was the site of a recent community outreach project where service learning provided the basic framework for this course. For the duration of an entire semester, students and faculty became entrenched in the community. The service learning project included an initial site visit for students to meet city staff that served as the community contacts for the project. Additionally, the studio design team made other site visits/ trips to Miami to present the findings throughout the project to the mayor, city council, and interested citizens. Throughout the project, the product that the design team produced and presented to the community was two-fold. First, written reports were created that described the ideas behind the design, and secondly, traditional designs, in graphic form, were produced, illustrating the ideas of the project further. At the conclusion of the project, the studio design team presented the city with a final report that detailed the entire project process throughout the semester. This report serves not only as a written record of the project, but it also will assist the city in increasing support for the projects and programs that were illustrated by the design team so that the city can become more competitive as they seek state and federal funding for the projects. This research proves that service learning is not only beneficial to the students and faculty teams that work on the projects, but that these projects also offer a tangible asset to the community, strengthening the community from within.
Continuous Audit and Enterprise Resource Planning Systems: A Case Study of ERP Rollouts in the Houston, TX Oil and Gas Industries
Authors: Haynes Robin , Li Chunyan 
Published: March 2016

ABSTRACT
The use of enterprise resource planning software has become an essential part of conducting business for many small, medium, and large companies. This paper presents a case study of accounting information specialists in different divisions of the same conglomerate in the energy industry in Houston, Texas that engaged in anti-fraud audits following the rollout of enterprise resource planning (ERP) systems by implementing continuous auditing processes (CA). The results indicate that the adoption of an ERP system has a significant impact on the efficiency, fraud risk reduction, knowledge application, as well as the credibility of the auditing team. The most important factors for the successful use of fraud mitigation techniques rely on ERP systems, which have continuous audit functions. The major and minor themes that emerge from the results of this case study are thoroughly dissected and discussed. Future studies of the use of ERP and CA systems to combat fraud should examine how auditing teams can apply superior fraud detection through preparation and training, education, and on-the-job experience.
Merger Guidelines for Bidding Markets
Authors: Gagnepain Philippe , Martimort David 
Published: March 2016

Nous proposons un test simple qui détermine si une fusion entre entreprises devrait ou non être autorisée dans une industrie qui sélectionne les candidats à l’exploitation par des appels d’offres. Ce test est appliqué dans le cas particulier de l’industrie du transport urbain en France. Il élabore l’enchère optimale et tient compte de deux effets antagonistes : d’une part, la fusion est préjudiciable, car elle entraîne une perte de concurrence ; d’autre part, les gains d’efficacité potentiels jouent en faveur des entreprises qui fusionnent. Les deux effets peuvent être incorporés dans une unique condition qui détermine si la fusion permet d’améliorer le surplus net du consommateur. Nos résultats suggèrent que la fusion entre Transdev and Veolia améliore le surplus net du consommateur si les gains d’efficacité issus de la fusion permettent aux deux entreprises de diminuer leur inefficacité en termes de coûts d’au moins 17,9 % et 17,8 % respectivement. JEL Codes: L51, C51, L92.