bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responsiveness of anti‐VEGF treatment for polypoidal choroidal vasculopathy based on aqueous humour proteomics: A preliminary study
Authors: Wang Yuelin , Xing Dongjun , Duan Jialiang , Zhou Huiying , Meng Lihui , Geng Shuang , Chen Huan , Han Ruoan , Li Zhiqing , Ma Jingxue , Chen Youxin 
Published: October 2024

AbstractObjectivesPatients with polypoidal choroidal vasculopathy (PCV) exhibit variability in response to anti‐VEGF therapy. This study aimed to analyse the aqueous humour proteomic profiles of PCV patients and provide preliminary insights for the identification of biomarkers associated with anti‐VEGF drug responsiveness.MethodsPCV patients who were treatment‐naïve or untreated for more than 3 months were prospectively recruited from two hospitals in Beijing and Tianjin. Based on the relative changes in central macular thickness (ΔCMT/baseline‐CMT) before and after anti‐VEGF treatment, the PCV patients were divided into a good response (GR) group (≤−25%) and a poor response (PR) group (>−25%). Aqueous humour proteomics was performed by the Data‐independent Acquisition‐Mass Spectrometry (DIA‐MS) method, and differentially expressed proteins (DEPs) analysis between the different PCV groups and the control group was conducted. Key DEPs were selected for preliminary validation in the aqueous humour using the Luminex method retrospectively.ResultsA total of 31 PCV patients (31 eyes) were included, 13 in the GR group and 18 in the PR group. A total of 414 DEPs were identified, including 36 significantly upregulated proteins, such as G protein regulatory factor 10 (RGS10), podocin (PODN) and epidermal growth factor (EGF), and 32 downregulated proteins, including RAB11FIP4 (Rab11 family‐interacting protein 4), α‐synuclein (SNCA), haemoglobin subunit δ (HBD) and interleukin 6 (IL6). Compared to the cataract control group (10 eyes), 134 proteins were significantly upregulated, and 72 were downregulated. KEGG pathway enrichment analysis revealed that the GR and PR groups differ in terms of cell communication, and cell signal transduction. Protein–protein interaction analysis revealed interactions between EGF and various DEPs. Validation of aqueous humour proteins using the Luminex method revealed that changes in the levels of EGF were associated with the anti‐VEGF treatment response in PCV patients.ConclusionsPCV patients with good or poor anti‐VEGF responses exhibit distinct aqueous humour proteomic profiles. Aqueous EGF may serve as a biomarker for the ‘precise treatment’ of PCV.
“Doctor, would it surprise you if there were prescribing errors in this patient's medication?” Identifying eligible patients for in‐hospital pharmacotherapeutic stewardship: A matched case‐control study
Authors: Mahomedradja Rashudy F. , Lissenberg‐Witte Birgit I. , Sigaloff Kim C. E. , Tichelaar Jelle , van Agtmael Michiel A. 
Published: October 2024

AbstractBackgroundEvaluating a patient's medication list is critical to reduce prescribing errors (PEs), but is a labour‐ and time‐intensive process. Identification of patients at risk of PEs could improve the allocation of scarce time and resources, but currently available prediction tools are not effective.ObjectiveTo investigate whether ward doctors can identify patients at risk of PEs.MethodsThis prospective matched case‐control study was conducted on three clinical wards in an academic hospital. Otolaryngology and oncology ward doctors used clinical intuition to select patients requiring a clinical medication review (CMR) (cases). These patients were then matched 1:1 on age (±10 years) and number (±1) of prescriptions with patients not selected for CMRs on the internal medicine and upper gastrointestinal surgery ward (controls). A multidisciplinary in‐hospital pharmacotherapeutic stewardship team assessed the prevalence of PEs.ResultsA total of 387 patients with 5191 prescriptions were included. Overall, 799 PEs affecting 279 patients (72.1%) were identified. Most PEs (58.8%) occurred during hospitalization. There were no significant differences in age, number of prescriptions, sex, renal function or documented allergies or intolerances between the cases and controls or between controls and other patients who did not receive a CMR. The incidence of PEs was higher in cases than in controls (97.5% vs 72.5%, odds ratio = 14.8, 95% confidence interval [CI] 1.8–121.1, P = .002)). The rate of PEs was three times higher in cases than in controls (incidence rate ratio = 3.0, 95% CI 2.3–4.0, P < .001).ConclusionsWard doctors can effectively identify patients with PEs, and thus at risk of medication‐related harm, using clinical intuition.
Are Good Leaders Also Green Leaders? Differentiating Established and Environmental Leadership Styles, Their Antecedents, and Predictive Validity for Corporate Environmental Responsiveness
Authors: Schäpers Philipp , Guntermann Tabea , Heinemann Henrik , Mönke Franz W. 
Published: October 2024

ABSTRACTFollowing an established two‐dimensional dichotomy for environmental leadership, environmentally friendly behavior as a leadership style has become an important topic in both research and practice. However, so far, it has remained unclear how these new concepts relate to well‐established leadership styles such as transformational leadership, responsible leadership, and leaders' organizational citizenship behavior. In this study, we provide an in‐depth examination of the environmentally focused substyles in contrast to their well‐established counterparts, their antecedents, and the incremental value in predicting corporate environmental responsiveness (CER). For that purpose, we surveyed N = 211 German leaders: Confirmatory factor analysis (CFA) and path model analyses suggest that, overall, established leadership styles and their respective environmentally specific substyle are empirically distinct constructs. Moreover, environmentally specific leadership behaviors explained significant variance beyond established concepts in predicting corporate environmental sustainability. Finally, our analyses suggest that leaders' extraversion and political orientation emerge as valid predictors (i.e., antecedents) of environmental leadership behavior. Overall, this study shows that CER is influenced on an individual level, underlining the important role of leaders' behavior in a rapidly worsening climate crisis.
tiRNA‐Gly‐GCC‐002 promotes epithelial‐mesenchymal transition and fibrosis in lupus nephritis via FKBP5‐mediated activation of Smad
Authors: Liu Xueting , Zhang Ji , Liang Yan , Chen Xuanwen , Xu Shungang , Lin Sishi , Dai Yuanting , Chen Xinxin , Zhou Ying , Bai Yongheng , Chen Chaosheng 
Published: October 2024

Background and PurposeRenal interstitial fibrosis is a frequent pathological manifestation of lupus nephritis (LN). tRNA halves (tiRNAs) are acquired from tRNA‐derived small non‐coding RNAs (sncRNAs) and are associated with fibrosis. Our previous study indicated enhanced tiRNA‐Gly‐GCC‐002 (tiRNA002) levels in kidneys were positively related to LN‐related fibrosis. However, the precise molecular mechanism remains unclear.Experimental ApproachThe mimic and agomiR of tiRNA002 were introduced into tubular epithelial cells (TECs) and MRL/lpr mice by transfection. The levels of gene and protein expressions were quantified using real‐time quantitative polymerase chain reaction (RT‐qPCR), Western blot and immunofluorescence assays.Key ResultsIn TECs treated with LN serum, as well as in the kidneys of MRL/lpr mice, high levels of tiRNA002 directly influenced the epithelial‐mesenchymal transition (EMT) and extracellular matrix (ECM) deposition. Furthermore, tiRNA002 overexpression promoted EMT in TECs and accelerated renal interstitial fibrosis in MRL/lpr mice via Smad signalling. The target gene of tiRNA002, FKBP prolyl isomerase 5 (FKBP5), improved Smad signalling by interacting with phosphorylated Smad2/3. Silencing FKBP5 alleviated LN serum‐ or tiRNA002‐mimic‐induced EMT in TECs. In addition, FKBP5 overexpression reversed the tiRNA002 knockdown‐mediated reduction of EMT and ECM accumulation.Conclusions and ImplicationsThese findings indicated that tiRNA002 is markedly increased in LN, which facilitates renal fibrosis by promoting EMT via FKBP5‐mediated Smad signalling. Therefore, targeting tiRNA002 may be an innovative approach to treat renal interstitial fibrosis in LN.
Development of new Kir2.1 channel openers from propafenone analogues
Authors: Li Encan , Boujeddaine Najla , Houtman Marien J. C. , Maas Renee G. C. , Sluijter Joost P. G. , Ecker Gerhard F. , Stary‐Weinzinger Anna , van Ham Willem B. , van der Heyden Marcel A. G. 
Published: October 2024

Background and PurposesReduced inward rectifier potassium channel (Kir2.1) functioning is associated with heart failure and may cause Andersen‐Tawil Syndrome, among others characterized by ventricular arrhythmias. Most heart failure or Andersen–Tawil Syndrome patients are treated with β‐adrenoceptor antagonists (β‐blockers) or sodium channel blockers; however, these do not specifically address the inward rectifier current (IK1) nor aim to improve resting membrane potential stability. Consequently, additional pharmacotherapy for heart failure and Andersen–Tawil Syndrome treatment would be highly desirable. Acute propafenone treatment at low concentrations enhances IK1 current, but it also exerts many off‐target effects. Therefore, discovering and exploring new IK1‐channel openers is necessary.Experimental ApproachEffects of propafenone and 10 additional propafenone analogues were analysed. Currents were measured by single‐cell patch‐clamp electrophysiology. Kir2.1 protein expression levels were determined by western blot analysis and action potential characteristics were further validated in human‐induced pluripotent stem cells–derived cardiomyocytes (hiPSC‐CMCs). Molecular docking was performed to obtain detailed information on drug‐channel interactions.Key ResultsAnalogues GPV0019, GPV0057 and GPV0576 strongly increased the outward component of IK1 while not affecting the Kir2.1 channel expression levels. GPV0057 did not block IKr at concentrations below 0.5 μmol L−1 nor NaV1.5 current below 1 μmol L−1. Moreover, hiPSC‐CMC action potential duration was also not affected by GPV0057 at 0.5 and 1 μmol L−1. Structure analysis indicates a mechanism by which GPV0057 might enhance Kir2.1 channel activation.Conclusion and ImplicationsGPV0057 has a strong efficiency towards increasing IK1, which makes it a good candidate to address IK1 deficiency‐associated diseases.
Adaptive Synaptic Adjustment Mechanism to Improve Learning Performances of Spiking Neural Networks
Authors: Lee Hyun‐Jong , Lim Jae‐Han 
Published: October 2024

ABSTRACTSpiking Neural Networks (SNNs) are currently attracting researchers' attention due to their efficiencies in various tasks. Spike‐timing‐dependent plasticity (STDP) is an unsupervised learning process that utilizes bio‐plausibility based on the relative timing of pre/post‐synaptic spikes of neurons. Integrated with STDP, SNNs perform well consuming less energy. However, it is hard to ensure that synaptic weights always converge to values guaranteeing accurate prediction because STDP does not change synaptic weights with supervision. To address this limitation, researchers have proposed mechanisms for inducing STDP to converge synaptic weights on the proper values referring to current synaptic weights. Thus, if the current weights fail to describe proper synaptic connections, they cannot induce STDP to update synaptic weights properly. To solve this problem, we propose an adaptive mechanism that helps STDP to converge synaptic weights directly based on input data features: Adaptive synaptic template (AST). AST leads synaptic weights to describe synaptic connections according to the data features. It prevents STDP from changing synaptic weights based on abnormal weights that fail to describe the proper synaptic connections. This is because it does not use the current synaptic weights that can disturb proper weight convergence. We integrate AST with an SNN and conduct experiments to compare it with a baseline (the SNN without AST) and benchmarks (previous works to improve STDP). Our experimental results show that the SNN using AST classifies various data sets with 6%–39% higher accuracy than the baseline and benchmarks.
Feasibility and Acceptability of Providing Cognitive Remediation in a Large USA System of Coordinated Specialty Care for Early Psychosis
Authors: Medalia Alice , Saperstein Alice M. , Wall Melanie M. , Basaraba Cale N. , Bello Iruma , Nossel Ilana , Dixon Lisa B. 
Published: October 2024

ABSTRACTIntroductionMultinational treatment guidelines support providing cognitive remediation to people recently diagnosed with schizophrenia, but the feasibility of implementing the treatment on a large scale is less well understood.MethodsThis study took place between 2019 and 2023 at 14 clinics within a large network of programs providing early intervention services to people aged 16–30 experiencing nonaffective psychosis. Clinics were randomly assigned to deliver cognitive remediation as twice‐weekly clinician‐led groups (N = 5), cognitive remediation as once‐weekly clinician‐led groups with homework (N = 6), or treatment as usual (N = 3). All clinics screened for cognitive health need to guide treatment planning. Clinical teams (N = 11) received training to provide cognitive remediation. Program evaluation data were analysed for feasibility and acceptability.ResultsScreening for cognitive health needs was completed on 77% of the 1193 participants enrolled at the 11 clinics offering cognitive remediation. Clinicians identified cognitive difficulties in 53.9% (n = 496) of screened participants and referred 27% (n = 134) of these participants to cognitive remediation. Of referred participants, 77.6% (n = 104) initiated treatment, and n = 41 completed the treatment. The rate of referral was nearly double, and treatment initiation was significantly higher at programs delivering once‐weekly (84.3%) than twice‐weekly (64.4%) treatment but the difference in the rate of treatment completion was statistically nonsignificant. Satisfaction among treatment completers was high.ConclusionsReferrals to cognitive remediation required systemic support of a feasible cognitive health screening process. About a quarter of people with clinician‐identified cognitive health needs were referred to cognitive remediation. Feasibility data suggest a flexible model of treatment delivery may facilitate implementation in this service setting.
Resource allocation choices in asset‐intensive industries
Authors: Sigalas Christos 
Published: October 2024

AbstractThe purpose of this study is to examine the determinants of tangible and intangible resource allocation in asset‐intensive organizations, by employing a qualitative and a quantitative study in the setting of the maritime shipping industry. First, the study employs seven in‐depth interviews to identify the firm‐specific factors that shape resource allocation decision‐making. Second, the study utilizes a unique panel dataset of public maritime shipping companies for the period 2010–2020 to empirically investigate the identified determinants of resource allocation choices. The results indicate that factors, such as firm's risk‐seeking profile, smaller size, limited cash liquidity, capability to access capital, lower cost of equity capital, higher cost of debt capital, lower level of insiders' ownership, younger CEO, and limited environmental‐related disclosures are positively affecting the number of tangible resources allocated. The findings, apart from enriching the body of literature, have some managerial implications that are discussed herein.
Which is the best imaging modality to diagnose a manica flexoria tear?
Authors: Bacon Rebecca L. , Jones Rebecca 
Published: October 2024

SummaryThe manica flexoria (MF) is an extension of the medial and lateral borders of the superficial digital flexor tendon (SDFT) that forms a sleeve around the deep digital flexor tendon (DDFT), within the digital flexor tendon sheath (DFTS), just proximal to the metacarpo/metatarsophalangeal joint. Tears of the MF have been described associated with cases of nonseptic tenosynovitis presenting with lameness, with ponies and cobs being over‐represented. Ultrasonography and contrast tenography are the predominant imaging modalities used to diagnose tears of the MF, with tenoscopic evaluation still serving as the gold standard. However, the sensitivity and specificity of additional techniques such as contrast computed tomographic tenography and MRI are now being investigated as other modalities that could be of value to identify MF tears. Additional techniques have been described to combine with traditional ultrasonography, with the aim to improve the sensitivity of identifying MF tears, such as dynamic extension/flexion techniques and saline injections of the DFTS. The overall aim of this paper was to review current evidence to determine the best noninvasive diagnostic imaging modality, with a high sensitivity and specificity, to more accurately diagnose MF tears and aid more thorough surgical planning.
Nociceptive TRP channels function as molecular target for several antifungal drugs
Authors: Okabe Shota , Takahashi Kenji , Hashimoto Miho , Ohta Toshio 
Published: October 2024

AbstractBackground/objectivesTopically applied antifungal agents can induce adverse effects, such as pain and irritation. The transient receptor potential (TRP) channels—TRPA1 and TRPV1—mainly expressed in sensory neurons, act as sensors for detecting irritants. This study aims to evaluate the involvement of nociceptive channels in topical antifungal‐induced pain and irritation. We tested nine topical antifungals belonging five classes: isoconazole, econazole, miconazole, clotrimazole, and ketoconazole as imidazoles; liranaftate as a thiocarbamate; terbinafine as an allylamine; amorolfine as a morpholine; and butenafine as a benzylamine.MethodsIntracellular calcium concentrations ([Ca2+]i) and membrane currents in response to antifungals were measured to estimate channel activity using heterologously expressing cells and isolated mouse sensory neurons.ResultsIn mouse TRPA1‐expressing cells, all the tested drugs induced an increase in [Ca2+]i, which was abrogated or reduced by a TRPA1 blocker. Although many drugs evoked the TRPA1‐nonspecific [Ca2+]i response at high concentrations, responses to clotrimazole, ketoconazole, and liranaftate were TRPA1 specific and elicited current responses in TRPA1‐expressing cells. In mouse TRPV1‐expressing cells, clotrimazole and ketoconazole elicited [Ca2+]i and current responses. In mouse sensory neurons, liranaftate‐induced increase in [Ca2+]i was abrogated by a TRPA1 blocker and Trpa1 deletion. Responses to ketoconazole were inhibited by TRPA1 and TRPV1 blockers and by the genetic deletion of either channel.ConclusionThese results suggest that topical antifungal‐induced pain and irritation are attributable to the activation of nociceptive TRPA1 and/or TRPV1 channel/s. Consequently, caution should be exercised in the use of topical antifungals with symptoms of pain.
Efficacy and safety of sucroferric oxyhydroxide versus sevelamer carbonate: A systematic review and meta‐analysis
Authors: Georgopoulos Christos , Duni Anila , Stamellou Eleni , Kitsos Athanasios , Gouva Charikleia , Dounousi Evangelia 
Published: October 2024

AbstractIntroductionPhosphate binders are commonly used in patients receiving kidney replacement therapy (KRT), aiming to reduce and maintain serum phosphorus. Chronic kidney disease‐mineral and bone disorder has been linked to reduced lifespan and worsened quality of life. This study aims to examine the efficacy and safety of sucroferric oxyhydroxide versus sevelamer carbonate in patients receiving KRT.MethodsThe data sources examined were MEDLINE (PubMed), Scopus, and the Cochrane Central Register of Controlled Clinical Trials with a search deadline of October 2023. We examined randomized controlled trials that compared sucroferric oxyhydroxide versus sevelamer carbonate in the adult population receiving KRT. We performed a meta‐analysis combining the data from trials, using R‐studio.FindingsInclusion criteria were met by five randomized trials. There was no statistically significant difference in the reduction of serum phosphorus between the two groups (MD: −0.07 mmol/L, 95% CI‐random effects: −0.15 to 0.02). In the same line, a non‐statistically significant difference was observed in serum i‐PTH reduction between the two drugs (MD = −1.53 mg/dL, 95% CI = (−4.45, 1.4), p = 0.26, random effects model). No statistically significant difference was observed in all adverse events between the two groups (odds ratio: 1.11, 95% CI: 0.65–1.88, random effects model). Further analysis of gastrointestinal adverse events revealed that sevelamer carbonate increases gastrointestinal adverse events by up to 60% (odds ratio: 1.60, 95% CI: 1.31–1.97, common (fixed) effect model).DiscussionThis meta‐analysis of randomized trials showed that both drugs, sucroferric oxyhydroxide and sevelamer equally and effectively controlled serum phosphorus levels, whereas sucroferric oxyhydroxide revealed a better profile in terms of gastrointestinal adverse events. Sucroferric oxyhydroxide is a valuable option for patients receiving KRT when sevelamer carbonate is more difficult to tolerate.
Psoriasis management tree based on comorbidity
Authors: Amara Shivkar , Pasumarthi Anusha , Parikh Neil , Kodali Nilesh , Lebwohl Mark , Monks George 
Published: October 2024

AbstractPsoriasis, a common chronic inflammatory skin disorder, encompasses various subtypes, including guttate, pustular, erythrodermic, and the most common type, plaque psoriasis. Irrespective of the subtype, psoriasis can manifest with multisystemic presentations, including psoriatic arthritis, metabolic disorders, cardiovascular disease, malignancies, chronic kidney disease (CKD), psychiatric illness, and inflammatory bowel disease (IBD). Many comorbidities and concomitant conditions must be considered when selecting the most appropriate therapy for a patient (Kaushik et al., 2019 and Monks et al., 2021) . Ongoing clinical trials and the development of new therapeutic targets contribute to the continuous improvement of available treatment options. Given the dynamic landscape of therapies, particularly when managing complex patients with multiple comorbidities, dermatologists are constantly challenged with the task of adeptly tailoring treatments to each psoriasis patient. This article systematically reviews the current evidence, presenting it as an updated Psoriasis Decision Tree to assist physicians in selecting tailored treatment options.