bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the RT‐LAMP and LAMP methods for detection of Mycobacterium tuberculosis
Authors: Wu Dandan , Kang Jiwen , Li Baosheng , Sun Dianxing 
Published: September 2017

BackgroundThe current methods for detecting Mycobacterium tuberculosis (Mtb) are not clinically optimal. Standard culture methods (SCMs) are slow, costly, or unreliable, and loop‐mediated isothermal amplification (LAMP) cannot differentiate live Mtb.MethodsThis study compared reverse transcription (RT)‐LAMP, LAMP, and an SCM for detecting Mtb. A first experiment tested the sensitivity and specificity of primers for 9 species of Mycobacterium (H37Rv, M. intracellulare, M. marinum, M. kansasii, M. avium, M. flavescens, M. smegmatis, M. fortuitum, and M. chelonae); and 3 non‐Mycobacterium species (Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae). A second experiment tested sputum specimens for the presence of Mtb, from 100 patients with tuberculosis (clinical) and 22 from patients without tuberculosis (control), using Roche solid culture (SCM), LAMP, and RT‐LAMP. In the clinical samples.ResultsThe rates of positivity for Mtb of the SCM, LAMP, and RT‐LAMP methods were 88%, 92%, and 100%, respectively. The difference in detection rate was significant between RT‐LAMP and SCM, but RT‐LAMP and LAMP were comparable. In the control group, the detection rates were nil for all three methods.ConclusionThe specificities of the methods were similar. The sensitivity of RT‐LAMP was ~10‐fold higher than that of LAMP for detecting Mtb. Unlike LAMP, RT‐LAMP could identify viable bacteria, and was able to detect a single copy of Mtb. Among SCM, LAMP, and RT‐LAMP, the latter is the most suitable for wide use in the lower‐level hospitals and clinics of China for detecting Mtb in sputum samples.
Deployment characteristics and long‐term PTSD symptoms
Authors: Morissette Sandra B. , DeBeer Bryann B. , Kimbrel Nathan A. , Meyer Eric C. , Gulliver Suzy B. 
Published: September 2017

AbstractObjectiveThe impact of number, length, and time between (i.e., “dwell time”) deployments on long‐term Diagnostic and Statistical Manual of Mental Disorders Fourth Edition posttraumatic stress disorder (PTSD) symptoms was examined in post‐9/11 U.S. veterans.MethodThis cross‐sectional design includes data from 278 veterans participating in a larger longitudinal research program of postdeployment recovery. Measures included self‐report questionnaires and the Clinician Administered PTSD Scale.ResultsHierarchical regression was used to evaluate the independent contributions of deployment characteristics on long‐term PTSD symptoms after controlling for demographics and combat exposure. As expected, dwell time was a significant predictor of long‐term PTSD symptoms (β = − 0.17, p = .042; F5,108 = 8.21, ∆R2 = 0.03, p < .001). Follow‐up analyses indicated that dwell time of less than 12 months was associated with significantly greater long‐term PTSD symptoms than those deployed once or with dwell time greater than 12 months.ConclusionIn addition to combat exposure, time between deployments warrants clinical attention as an important deployment characteristic for predicting long‐term PTSD symptoms.
Thirty‐day morbidity and mortality following otologic/neurotologic surgery: Analysis of the national surgical quality improvement program
Authors: Schwam Zachary G. , Michaelides Elias , Kuo Phoebe , Hajek Michael A. , Judson Benjamin L. , Schutt Christopher 
Published: September 2017

Objectives/HypothesisTo determine the rate and timing of, as well as risk factors for, postoperative morbidity and mortality following otologic and neurotologic surgery.Study DesignRetrospective cohort study.MethodsA total of 1,381 patients were identified in the American College of Surgeons National Surgical Quality Improvement Program for the years 2005 to 2010. Simple summary statistics, χ2, and multivariable logistic regression were performed.ResultsLateral skull base/neurotologic tumor resection (LSB) was done in 35.9%, and middle ear/mastoid procedures (MEM) were performed in 63.5%. The overall adverse event rate was 10.4%, although it was significantly higher for LSB (24.2%) and lower for MEM (2.6%). The overall mortality rate was 1.4%. Complications occurred postdischarge in 40.4% of cases. The outpatient setting (odds ratio [OR]: 0.31, 95% confidence interval [CI]: 0.15‐0.65) and undergoing MEM (OR: 0.23, 95% CI: 0.12‐0.47) were associated with lower risk of experiencing a complication. Impaired functional status (OR: 10.45, 95% CI: 3.65‐29.89) was associated with postoperative mortality. An open wound preoperatively was associated with multiple causes of postoperative morbidity.ConclusionsPatients undergoing approaches to the skull base and neurotologic tumor resections had the higher adverse event rate. Open wounds were predictive of several postoperative complications, and poor functional status was associated with mortality. Patients with significant comorbidities should be evaluated early on in their postoperative course to prevent readmission as well as major morbidity and mortality.Level of Evidence2b. Laryngoscope, 128:1431–1437, 2018
1H NMR Study of “Host–Guest” Interactions of Micellar Assemblies from Amphiphilic Invertible Polymers and Peptides
Authors: Kohut Ananiy , Zholobko Oksana , Hevus Ivan , Voronov Andriy 
Published: September 2017

Abstract“Host–guest” interactions between self‐assembled micellar nanostructures from amphiphilic invertible polymers (AIPs) and two peptides, swine‐origin Influenza A surface protein Hemagglutinin and research antibody peptide V5, are investigated by changing the polymer concentration and polymer/peptide ratio in the aqueous solution. Formation of mixed micellar assemblies from AIP and each peptide is revealed using detailed 1H NMR spectroscopic study. Peptide molecule localization in the micellar assemblies depends on the specific interactions between amino acid functional groups of the peptide and polymer fragments. The resulting mixed micellar structures can be considered as a promising material toward delivery and stimuli‐responsive sustained release of peptides.
Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High‐Fat Diet in Mice through PPAR‐α and Nrf2 Upregulation with Concomitant SREBP‐1c and NF‐kB Downregulation
Authors: Hernández‐Rodas María C. , Valenzuela Rodrigo , Echeverría Francisca , Rincón‐Cervera Miguel Ángel , Espinosa Alejandra , Illesca Paola , Muñoz Patricio , Corbari Alicia , Romero Nalda , Gonzalez‐Mañan Daniel , Videla Luis A. 
Published: September 2017

ScopeNonalcoholic fatty liver disease is the most common cause of liver disease, for which there is no validated drug therapy at present time. In this respect, the PUFA docosahexaenoic acid (DHA; C22:6 n‐3) modulate lipid metabolism in the liver, and extra virgin olive oil (EVOO) has hepatoprotective effects.Methods and resultsThe effect of combined DHA (C22:6 n‐3) and EVOO administration to mice on oxidative stress and metabolic disturbances induced by high‐fat diet (HFD) is evaluated. Male C57BL/6J mice are fed with a control diet (10% fat, 20% protein, and 70% carbohydrates) or an HFD (60% fat, 20% protein, and 20% carbohydrates) for 12 weeks. Animals are supplemented with DHA (50 mg/kg/day), EVOO (50 mg/kg/day), or DHA + EVOO through oral route. DHA + EVOO cosupplementation results in greater protection (p < 0.05) over that elicited by DHA or EVOO supply alone, when compared to the damage induced by HFD. DHA + EVOO significantly reduces hepatic steatosis, oxidative stress, systemic inflammation, and insulin resistance.ConclusionSynergistic beneficial effects of DHA + EVOO supplementation are associated with the activation/inactivation of key transcription factors involved in the above‐mentioned processes. Data presented indicate that dietary supplementation with DHA + EVOO drastically reduces the development of nonalcoholic fatty liver disease.
Development of an efficient approach for MMW imaging system to identify concealed targets inside the book
Authors: Kumar Bambam , Sharma Prabhat , Singh Dharmendra 
Published: September 2017

AbstractThe most puzzling task faces by security agency is detection and identification of the targets like, blade, and knife inside the book and capability to differentiate with book mark. Millimeter wave (MMW) imaging system may have good potential for this because of its resolution and penetration capability. Therefore, in this paper a statistics based adaptive algorithm is proposed for detection and identification of targets like blade, knife and book mark inside the book for MMW imaging system.
Wideband proximity coupled microstrip linear array design for 5G mobile communication
Authors: Diawuo Henry Abu , Jung Young‐Bae 
Published: September 2017

AbstractA novel low‐cost, high‐gain mm‐wave antenna has been presented. The antenna consists of a proximity‐coupled linear array with a novel feed structure which presents the idea of a segmented feedline in a series configuration below the patches creating a very wide bandwidth. The increased bandwidth is due to the manner of power coupling from the feedlines on the lower substrate to the patches on the upper substrate and back down to the next feedline. Very good agreement between simulated and measured results achieved shows that the proposed antenna structure is very efficient in achieving wideband characteristics and low sidelobe levels with conformal size. The antenna has a gain of over 13.5 dB with an HPBW of 15° ± 2° over a bandwidth of 27.5–28.5 GHz. It also exhibits a return loss below −10 dB with a bandwidth of 9% from 26.4 to 28.92 GHz.
High‐efficiency rectifier (5.2 GHz) using a Class‐FDickson charge pump
Authors: Bae Jongseok , Koo Hyungmo , Lee Hwiseob , Lim Wonseob , Lee Wooseok , Kang Hyunuk , Hwang Keum Cheol , Lee Kang‐Yoon , Yang Youngoo 
Published: September 2017

AbstractThis article presents a 5.2 GHz high‐efficiency rectifier, based on a Class‐F Dickson charge pump, for use in RF energy harvesting systems. A single‐stage Dickson charge pump with two Schottky diodes was adopted to produce a high‐output DC voltage. A harmonic source‐pull simulation was conducted to optimize the third harmonic impedance for the Class‐F harmonic termination. The proposed scheme is verified by designing and implementing a hybrid Class‐F Dickson charge pump for the 5.2 GHz band using two Schottky diodes in a package. The proposed rectifier has a very small size of 19 18 mm2, and the implemented rectifier exhibited a high RF‐to‐DC conversion efficiency of 64.1% and an output DC voltage of 5.1 V at an input power of 24 dBm for the 5.2 GHz single‐tone signal.
Modeling of field dependent Maxwell‐Wagner interfacial capacitance for bilayer metal‐insulator‐metal capacitors
Authors: Kannadassan D. , Mallick P. S. 
Published: September 2017

AbstractIn this letter, we have presented the modeling of field dependent Maxwell‐Wagner interfacial capacitance for bilayer metal‐insulator‐metal (MIM) capacitors. The model was verified with measured capacitance‐voltage characteristics of fabricated bilayer Al2O3/TiO2 MIM capacitors. The model reveals the origin of voltage linearity of MIM capacitors at low frequencies (<10 kHz). The proposed model for bilayer/multilayer MIM capacitors is very useful tool to design circuits for mixed signal, analog and digital circuits with low variation of capacitance for change in voltage.
Broadband circularly polarized square slot antenna with a G‐shaped feedline
Authors: Oteng Gyasi Kwame , Li Jian , Huang Yongjun , Guangjun Wen 
Published: September 2017

AbstractThis article presents the design of a compact circularly polarized square slot antenna fed by a G‐shaped strip feedline. The 3 dB axial ratio (AR) band can be achieved by modifying the feedline by simply extending it with an L‐shaped monopole and an inverted C‐shaped monopole. In simple terms, the extended part resembles a G‐shaped patch when viewed from the top. To extend the AR bandwidth achieved by the G‐patch, perturbations in the form of a U‐strip and an L‐shaped slot were introduced in the wide slot and ground plane, respectively. Measured results showed a wide 3 dB axial ratio bandwidth of 37.1% (4.5–6.55 GHz) and an impedance bandwidth of 70.1% (3.32–6.95 GHz). The proposed antenna is suitable for wideband circular polarization applications in the IEEE C‐band.
A single‐aperture duplex antenna with dual circular polarizations
Authors: Lu Yun‐Long , Wang Yi , Gao Steven , Hua Changzhou , Liu Taijun 
Published: September 2017

AbstractThis article proposes a novel design of a compact single‐aperture dual circular polarization (CP) antenna with integrated duplexing functions using a phase controllable coupled resonator structure. To the best of the authors’ knowledge, this is the first report of a multifunctional CP antenna with integrated duplexing performance and dual polarizations. The two orthogonal CPs are realized for the two respective filtering channels. Each channel contains a phased filtering power divider forming the dual‐feed to a patch to achieve right‐hand or left‐hand CP (RHCP or LHCP). The required output phases of the dividers are realized by varied configurations of the coupled λ/2‐resonator pairs. A duplex‐CP‐antenna with RHCP/LHCP at the downlink/uplink (2.45/2.7 GHz) is designed, fabricated, and measured. It achieved a 3‐dB AR bandwidth of 3.2/7.7% at the downlink/uplink and an isolation better than 20 dB. Meanwhile, the antenna showed expected second‐order filtering characteristics at both channels.
Characterization of a self‐aligned RTD using a SiNx sidewall process for high‐speed applications
Authors: Lee Kiwon , Lee Hoyeon , Lee Jongwon 
Published: September 2017

AbstractIn this article, an InP‐based self‐aligned resonant‐tunneling‐diode (RTD) using a SiNX sidewall process has been fabricated and characterized for high‐speed microwave applications. A plasma‐enhanced dry‐etch technique has been used to form a vertical emitter mesa. The measured peak currents are almost constant at a peak voltage due to negligible thermionic emission in a wide temperature range up to 125°C. The extracted series resistance of the fabricated self‐aligned RTD is 14.5 Ω, which is reduced by 27% compared with that of the nonself‐aligned RTD by reducing the spacing between emitter mesa and collector metal. To the best of authors’ knowledge, this is the first attempt to characterize a self‐aligned RTD using the dry‐etched mesa and the SiNX sidewall structure.
A reconfigurable dual‐beam planar antenna with beam switching capability
Authors: Lalithamma Snehalatha , Pathak Nagendra P. , Manhas S. K. 
Published: September 2017

AbstractA novel dual‐beam planar antenna with pattern reconfigurable feature is presented in this article. The proposed design uses four antenna elements, two of which are connected at a time to provide dual‐beam reconfigurability. Four PIN diodes are employed to achieve switching of the dual‐beam in four directions. A prototype of the antenna is fabricated on FR4 substrate with a single coaxial feed and the results are validated by measurement.
A microstrip photonic crystal bandgap device with a switchable negative epsilon plasma element
Authors: Wang B. , Lee R. , Colon R. , Cappelli M. A. 
Published: September 2017

AbstractWe present a microstrip photonic bandgap (PBG) device with a switchable plasma element integrated into the patterned ground plane. A pulsed laser plasma is generated in one of the PBG cavity structures creating a medium having an effective negative permittivity in the 8–10 GHz frequency range due to the high plasma density ne = 1017 cm−3. The PBG structure consists of a linear array of seven cavities along the length of the microstrip manufactured by removing cylindrical portions of copper in the ground plane. The plasma is produced in the central cavity of the PBG array and recombines over times of several microseconds allowing for the characterization of the microstrip transmission over a range of plasma density. The results confirm a switchable transmission due to plasma interactions with the electromagnetic field within the PBG structure.
Ultra‐short pulse generator using 0.13‐μm CMOS
Authors: Tang Xusheng , Huang Fengyi , Wang Xiaoyu , Chang Tianyu , Zhang Youming 
Published: September 2017

AbstractThis article presents ultra‐short pulse generators based on shaping‐differential and phase detect circuits fabricated in a 0.13‐μm complementary metal‐oxide‐semiconductor process. By using a differential circuit, the shaping‐differential and phase detect pulse generators produce pulses with a pulse width of 51.5 and 79.0 ps, respectively. The measured output powers from the shaping‐differential and phase detect pulse generators are −34.6 dBm at 16 GHz, and −28.3 dBm at 8 GHz, respectively.
Pattern recognition based on enhanced multifeature parameters for vibration events in φ‐OTDR distributed optical fiber sensing system
Authors: Xu Chengjin , Guan Junjun , Bao Ming , Lu Jiangang , Ye Wei 
Published: September 2017

AbstractA new multifeature recognition method for optical fiber vibration signals is proposed to solve the difficulty with the present long‐distance distributed optical fiber sensing systems based on phase‐sensitive optical time‐domain reflectometer (φ‐OTDR) in effectively distinguishing vibrational intrusions. Firstly, wide‐band background noise is reduced by spectral subtraction to enhance time‐frequency characteristics of vibration signals. Then, multifeature parameters including short‐time energy ratio, short‐time level crossing rate, vibration duration, and power‐spectrum energy ratio are extracted from the vibration signals. Finally, by utilizing support vector machine classifiers to identify multifeature vectors of different types of vibration signals, patterns of vibration events are recognized accurately. Experiments show that after using this method to process 800 vibration signal samples generated by four different vibration events, namely, taping, striking, shaking, and crushing, the signal‐to‐noise ratio is enhanced by more than 10 dB and the recognition rates of vibration events are over 90%. The experimental results prove that this method can improve the classification accuracy of vibration events detected by φ‐OTDR distributed optical fiber sensing systems with a recognition time below 0.6 s, especially for long distances.
Analysis of the wireless power transfer system using electromagnetic topology method
Authors: Kim Minhyuk , Jung Hyun‐Kyo , Park Sang Wook 
Published: September 2017

AbstractIn this article, a new approach is proposed to analyze a wireless power transfer (WPT) system using the electromagnetic topology (EMT) method. Characteristic parameters for the junction and tube in the EMT method are obtained from the equivalent circuit of the WPT system. The load voltage is computed using the Baum–Liu–Tesche equation, which is the solver for the EMT method. A simple WPT system is analyzed to confirm the validity of the proposed method by comparing it with the conventional full wave analysis method. The analysis results obtained by the proposed method are in good agreement with the results of the conventional method.
Compact wideband band pass microstrip filter loaded by triangular split ring resonators
Authors: Nasraoui Hanane , Capobianco A. D. , Mouhsen Ahmed , El Aoufi Jamal , Mouzouna Youssef , Taouzari Mohamed 
Published: September 2017

AbstractA compact wideband band‐pass microstrip filter based on triangular split ring resonators is presented. The center frequency of the proposed structure is 3.1 GHz and the 3 dB bandwidth results 1.05 GHz. Good agreements between the simulated and measured results demonstrates the effectiveness of the proposed design. The size of the filter is 14 × 50 mm2 only.
Modeling of an uncooled CMOS THz thermal detector with frequency‐selective cross‐dipole antenna and NMOS temperature sensor
Authors: Chen Fei , Yang Jiao , Li Zimeng 
Published: September 2017

AbstractIn this article, we present modeling and simulations of an uncooled thermal THz detector. The detector consists of an on‐chip cross‐dipole antenna, polysilicon resistors, and a temperature sensor. Electromagnetic, thermal, electrical modeling, and simulations of the detector are presented. The three submodels are as follows: THz electromagnetic energy is first selectively absorbed by the antenna realized in the metallization layer. The absorbed wave energy is then converted to Joule heat energy via resistors. Finally, the heat‐generated temperature rise is detected by the temperature sensor. The detectors at three typical THz frequencies of 0.8, 2.9, and 28.3 THz are designed in standard 0.18 μm CMOS technology. Their simulated voltage responsivity is 6.3 V/W at 0.8 THz, 7.2 V/W at 2.9 THz, and 8.2 V/W at 28.3 THz. The noise equivalent power (NEP) is 0.14 μW/√Hz at the three respective frequencies.
Broadband design of circularly polarized high‐gain Fabry‐Perot resonator antenna with simple array thinning technique
Authors: Liu Zhen‐Guo , Lu Wei‐Bing 
Published: September 2017

AbstractIn this letter, a broadband high‐gain circularly polarized Fabry‐Perot resonator antenna (CP‐FPRA) with simple array thinning technique is proposed. The proposed antenna consists of a single layer partially reflective surface (PRS) formed by ring frequency selective surface (FSS) and a four sequential rotated sparse primary microstrip patch radiators backed with ground. The inter‐spacing of adjacent primary radiator is around 1 λ0, which is larger than the typical value of 0.5 λ0 in microstrip patch array. A prototype antenna operating at 10 GHz is designed. Simulated and experimental results show that a broad common bandwidth for |S11| ≤ −10 dB and gain‐drop ≤2 dB and axial ratio ≤3 dB is obtained, in which the good CP radiation properties such as high gain, low side lobe level are also proposed.
A Bioinformatic Algorithm for Analyzing Cell Signaling Using Temporal Proteomic Data
Authors: Zhang Chunchao , Chen Yue , Mao Xinfang , Huang Yin , Jung Sung Yun , Jain Antrix , Qin Jun , Wang Yi 
Published: September 2017

AbstractSignificance analysis of proteomic data generated by LC‐MS/MS is challenging owing to great data variability originated from biological, operational, and instrumental variations. Protein quantification by LC‐MS/MS either in absolute or relative scale is often highly skewed, which put limitations on model‐based statistical inference. For this purpose, we have developed an alternative nonparametric statistical algorithm (named IQR algorithm) for significance analysis of temporal proteomic data and have successfully applied our strategy in finding gefitinib‐targeted transcription factors and coregulators in Epidermal Growth Factor (EGF)‐stimulated HeLa cells. Our strategy relies on a reference group composed of more than a dozen of datasets collected at different experimental times, thus, accurately captures biological variations measured in quartile scale. The algorithm considers six categories and calculates signal strength when performing significance analysis of proteins of different abundances. This stratified strategy allows confident identification of well‐characterized EGF responders (e.g. EGR1, JUN, FOSB, BHLHE40, NR4A1, and NR4A2) and unexplored gefitinib induced transcription factors and coregulators in HeLa cells. Gene set enrichment analysis has validated ErbB signaling pathway as the major inhibitory target of gefitinib. The identification of several gefitinib‐inducible transcription factors implicates alternative signaling pathways as potential druggable pathways in gefitinib‐resistant or insensitive patients.