bluuebunny/crossref_metadata_2025_split huggingface dataset:
Y27632 induces tongue squamous cell carcinoma cell apoptosis through MAPK-ERK/JNK signal
Authors: Zhang Xiuling , Zu Tingjian , Wen Jie , Zhou Qian 
Published: October 2024

Abstract

Objectives
ROCK signaling is considered a therapeutic target for oral squamous cell carcinoma (OSCC). Y27632, a well-established ROCK inhibitor, has previously been reported to block oral squamous cell carcinoma cell growth and has shown cell type dependence in the treatment of other cancers. TP53 is one of the most frequently mutated genes in head and neck cancer. Here, we aim to investigate the role of Y27632 in wild-type and p53 mutant (R175H) SCC9 cells.

Methods
The p53-mutation (R175H) and p53-null SCC9 cell line were conducted, then, CCK8, colony formation, wound-healing assays, and transwell assay were employed to investigate the role of Y27632 in wtp53 and mutp53 SCC9 cells. The effects of Y27632 in SCC9 cells were also confirmed by the knockdown of ROCK1/2. Additionally, cell cycle and apoptosis were assessed using flow and western blot analysis. The impact of Y27632 on cell senescence was confirmed through the senescence-associated β-gal staining. Furthermore, the inhibition of Y27632 was examined in vivo using tumor-bearing nude mice.

Results
Our study demonstrates that Y27632 effectively impeded the proliferation of tongue squamous cell carcinoma (TSCC) cells in vitro and in vivo. Additionally, the proliferation and migration of wtp53 and mutp53 SCC9 cells were also significantly suppressed by Y27632 or ROCK siRNA in vitro. Mechanistically, Y27632 induced apoptosis in SCC9 cells via the MAPK-ERK/JNK signaling pathway.

Conclusions
Our data demonstrated that Y27632 induces apoptosis in SCC9 cells via the MAPK-ERK/JNK signaling pathway, regardless of the presence of p53 mutant variants (R175H). This will provide a potential therapeutic drug for TSCC treatment in the future.
Assessment and multi-scenario simulation of ecosystem service values in Southwest China’s mountainous and hilly region
Authors: Zhu Bing , Yang Yan , Meng Yu , Chen Juan 
Published: October 2024

Abstract
The southwestern mountainous and hilly regions of China are vital ecological barriers upstream of the Yangtze River. Assessing and simulating changes in ecosystem service value (ESV) in this area is essential for ensuring sustainable ecological development. In this study, our purpose was to evaluate and simulate the spatial patterns as well as trends in the changes shown by the ESV in Yanting County, China, from 2020 to 2030 via a grid-scale using the equivalent factor method and the Markov–patch-generating land use simulation model. The results indicated that (1) from 2020 to 2030, forest, cultivated, and construction lands would be the main types of land use. (2) In 2030, the projected ESVs in Yanting County under the as-usual, low-carbon, and shared development scenarios were 5.31, 5.30, and 4.99 billion RMB, respectively. Compared to the 2020 ESV of Yanting County, the as-usual scenario and low-carbon scenario ESVs increased. The shared development scenario ESVs decreased. It reflects the contra-diction between urbanization, industrialization, agricultural production, and ecological protection in Yanting County. The spatial distribution of the ESVs of all three scenarios showed an agglomeration trend. (3) Given the background of national food security and carbon peaking and carbon neutrality, the setting of a low-carbon development scenario combined with a shared development scenario appears to be more suitable for the future development of Yanting County, which is conducive to the rational planning of land-use patterns and the sci-entific growth of ESV in Yanting County. This study underscores the critical importance of integrating ESVs in sustainable land-use planning and management, and provides a reference for the rational use of land resources, land spatial planning, and policy-making for ecological protection in Yanting County.
The BIAD Standards: Recommendations for Archaeological Data Publication and Insights From the Big Interdisciplinary Archaeological Database
Authors: Reiter Samantha S. , Staniuk Robert , Kolář Jan , Bulatović Jelena , Rose Helene Agerskov , Ryabogina Natalia E. , Speciale Claudia , Schjerven Nicoline , Paulsson Bettina Schulz , Lee Victor Yan Kin , Canteri Elisabetta , Revill Alice , Dahlberg Fredrik , Sabatini Serena , Frei Karin M. , Racimo Fernando , Ivanova-Bieg Maria , Traylor Wolfgang , Kate Emily J. , Derenne Eve , Frank Lea , Woodbridge Jessie , Fyfe Ralph , Shennan Stephen , Kristiansen Kristian , Thomas Mark G. , Timpson Adrian 
Published: October 2024

Abstract
This article presents a series of recommendations for the publication of archaeological data, to improve their usability. These 12 recommendations were formulated by archaeological data experts who mined thousands of publications for different data types (including funerary practices, accelerator mass spectrometry dating, stable isotopes, zooarchaeology, archaeobotany and pathologies) during the initial construction of the Big Interdisciplinary Archaeological Database (BIAD). We also include data harmonisation vocabularies utilised for the integration of data from different recording systems. The case studies we cite to illustrate the recommendations are grounded in examples from the published literature and are presented in a problem/solution format. Though practically oriented towards the facilitation of efficient databasing, these recommendations – which we refer to as the BIAD Standards – are broadly applicable by those who want to extract scientific data from archaeological information, those who work with a specific region or theoretical focus and journal editors and manuscript authors. We anticipate that the use of the BIAD Standards will increase the usability, visibility, interoperability and longevity of published data and also increase the citations of those publications from which data were mined. The Standards will also help frame a unified foundation to support the continued integration of the natural sciences with archaeological research in the future.
Modeling of fuel combustion processes in a steam boiler when replacing standard burners
Authors: Baraniuk Oleksandr V. , Rachуnskyі Arthur Yu. , Chernousenko Olga Yu. 
Published: October 2024

To date, most of Ukraine's thermal power equipment has exhausted its factory resource and is physically and morally obsolete. One of the ways to solve this problem is to modernize it with the introduction of modern fuel-using equipment. The decisive direction in this situation is the focus on domestic technologies, which differ from imported counterparts due to better adaptability to domestic equipment, as well as a more favorable price policy for domestic manufacturers. The presented work was carried out in order to check the feasibility of replacing standard burners with burners built on the basis of jet-niche technology in power boilers, for example, such as the GМ-50 (Е-50-3,9-440GМ) steam boiler. For this, a computer model of a steam boiler and regular burners was developed. The research was carried out using the ANSYS Student software package. The application of the numerical modeling method using the ANSYS Student software complex made it possible to perform a detailed analysis of the fuel combustion process in a steam boiler, evaluate its efficiency and study the impact on environmental indicators. The object of the research was the processes that take place during the combustion of gaseous fuel and their influence on the performance indicators of the GМ-50 power boiler. The subject of the study was a CFD fuel model of the GМ-50 boiler, whose regular burners are capable of working on both liquid and gaseous fuel. Methane was used as fuel. Both regular axial burners and burners built on the basis of jet-niche technology, which are more environmentally friendly, were used as burners. Verification of the CFD model, which took place using a known analytical technique, shows that the discrepancy between the values of analytical calculations and model calculations does not exceed 6.7 %. The average temperature of flue gases in the festoon window was selected as a comparison parameter. The temperature value of 1117 С was obtained analytically. Calculation using the CFD model developed in the ANSYS-CFX environment shows that the temperature value should be 1042 С. It was determined that regular burners are less environmentally friendly than, for example, modern jet-niche ones. So, for the coefficient of excess air  = 1.2, the average value of nitrogen oxides at the fuel outlet is 187 ppm. It makes sense to replace standard burners, for example, with jet-niche ones, which are most suitable for replacing standard ones.
EFFECT OF PHYSISORBED COLLECTOR ON INDUCTION TIME AND KINETICS IN FLOTATION OF COAL SLURRIES
Authors: КОНДРАТЬЕВ С.А. , ХАМЗИНА Т.А. 
Published: October 2024

Анализ литературных данных показал предпочтительность использования времени индукции, а не контактного угла в качестве критерия флотируемости угля. Исследована кинетика флотации угля в зависимости от поверхностных по отношению к границе раздела “газ - жидкость” свойств гетерополярных собирателей. На примере шламов угля марки Ж разных месторождений выполнены работы по определению корреляционной связи между скоростью растекания собирателей по поверхности воды и кинетикой флотации углей. Обосновано использование времени перемещения линии контакта сред трех агрегатных состояний по минеральной поверхности как времени индукции. На основании связи скорости растекания собирателя со временем перемещения линии смачивания (время индукции) и скоростью флотации установлено, что флотационная активность собирателя определяется его свойствами по отношению к границе раздела “газ - жидкость”.
The literature review discloses preferability of using the time of induction rather than the wetting angle as a criterion of coal floatability. The authors analyze kinetics of coal flotation as function of surface properties of heteropolar collectors relative to the gas-liquid interface. The correlation between the spreading velocity of collectors on water surface and the coal flotation kinetics is determined as a case-study of fat coal slurries. Justification is given for using the time of displacement of the boundary between three states of aggregation as the time of induction. From the correlation of the spreading velocity of a collector, displacement time of the contact line (induction time) and the flotation velocity, it is found that flotation activity of the collector is governed by its properties relative to the gas-liquid interface.
STOCHASTIC OPTIMIZATION MODEL SUPPLIES OF FLOTATION MATERIALS
Authors: СТЕПАНОВИЧ П. , ВУЙИЧ С. , ТРУМИЧ М. , ПРАШТАЛО Ж. , КУЗМАНОВИЧ М. 
Published: October 2024

Рассмотрены вопросы баланса между стабильностью горного производства и минимизацией расходов запасов. Приведены основные сведения о стохастической модели запасов, целевая функция ожидаемых затрат и информация о процедуре нахождения оптимального решения. Разработанная модель применяется к нахождению оптимального количества расходных материалов, необходимых для ведения флотационных работ на руднике, где ведется добыча свинца, цинка и меди.
Consumable supplies in mines (explosives and explosive devices, oil, lubricants, rubber, protective devices, spare parts for machinery and equipment, flotation reagents, etc.) should be sufficient for stable production. However, for mining operations, supplies are burden costs, as storing supplies increases operating costs. The logical question is how to achieve the balance between mine production stability and minimization of costs of supplies, that is, how to optimize supplies. The paper presents a quantitative model of stochastic supplies optimization as a possible answer to this question. The application was demonstrated in the specific case of polymetallic ore lead, zinc, copper, and silver mine flotation with value indicators.
INVESTIGATION OF PROPERTIES OF DOMESTIC BINDERS FOR DUST SUPPRESSION AT TAILINGS STORAGE FACILITIES
Authors: КРАСАВЦЕВА Е.А. , МАКАРОВ Д.В. , СВЕТЛОВ А.В. 
Published: October 2024

Представлены результаты исследований свойств связующих реагентов отечественного производства для пылеподавления хвостохранилища на примере одного из предприятий горнопромышленного комплекса Мурманской области. Определены динамика набора прочности образованных покрытий, изменение прочности в режиме “увлажнение - высыхание”, оценено влияние реагентов на водопроницаемость обработанного материала хвостов, проведено выщелачивание полимеризовавшихся концентратов в слабокислой и щелочной среде. Показана необходимость проведения комплексного исследования для обоснованного выбора связующего реагента.
The article presents the case-study of properties of domestic binders in dust suppression at tailing storage facilities at a mining and processing plant in the Murmansk Region. The strength development dynamics of the binder-formed blankets and the change in the strength in the wetting-drying mode are determined, the impact of chemical agents on water permeability of treated tailings is estimated, and leaching of polymerized concentrates in weakly acid and alkaline media is carried out. The authors emphasize essentiality of an integrated research for the well-founded choice of a binder.
A MODEL OF JOINT ROCK-PROPPANT DEFORMATION IN HYDRAULIC FRACTURING
Authors: ЖУРКИНА Д.С. , ЛАВРИКОВ С.В. , РЕВУЖЕНКО А.Ф. 
Published: October 2024

Исследована связь между двумя процессами: деформированием проппантного слоя под действием горного давления и изменением горного давления в окружающем массиве при сбросе давления нагнетающей жидкости. Для моделирования задачи деформирования проппанта (задача механики сыпучих сред) используется метод дискретных элементов, для моделирования перераспределения горного давления (задача механики горных пород) применяется разработанная ранее континуальная модель горной породы как среды с внутренними источниками и стоками энергии и метод конечных элементов. В результате численного моделирования показано, что в зависимости от предварительной истории нагружения и свойств среды в породном массиве могут реализовываться как устойчивый, так и неустойчивый режим деформирования. Для устойчивого режима даны расчеты равновесного давления на контуре трещины гидроразрыва, оцененo изменение пористости проппантного слоя. В неустойчивом режиме в породном массиве наблюдаются динамические проявления горного давления.
The study focuses on the connection between two processes: deformation of proppant under the action of rock pressure and the rock pressure change after injection pressure release. The modeling of proppant deformation (mechanics of granular medium) uses the discrete element method, and the rock pressure redistribution (rock mechanics) is modeled using the earlier developed model of rock as a medium with internal energy sources and sinks, and the finite element method. The numerical modeling shows that depending on the loading history and on the rock mass properties, the mode of deformation can be both stable and unstable. For the stable mode of deformation, the pressure balance is calculated at the created fracture boundary, and the change in the proppant porosity is estimated. In the unstable mode, rock mass experiences dynamic events induced by rock pressure.
PHYSICAL AND MECHANICAL PROPERTIES OF ORE AND ROCKS AFTER FLOODING
Authors: ЕРЕМЕНКО А.А. , ДАРБИНЯН Т.П. , ШАПОШНИК Ю.Н. , УСОЛЬЦЕВА О.М. , ЦОЙ П.А. 
Published: October 2024

Исследованы физико-механические свойства роговика, габбро-долерита и богатой халькопирит-пирротиновой руды Октябрьского месторождения Талнахского рудного узла, подвергшихся затоплению. Анализ петрографии, элементного и минералогического состава образцов показал, что существенных различий в их свойствах после затопления не наблюдается. Сравнение деформационно-прочностных характеристик при испытаниях горных пород и руды на одноосное сжатие и растяжение демонстрирует их уменьшение в водонасыщенном и увеличение в высушенном состоянии при комнатной температуре. Пределы прочности, модули упругости, сцепления и углы внутреннего трения имеют меньшие значения после высушивания, чем в исходном состоянии.
The authors investigate the physical and mechanical properties of hornstone, gabbro-dolerite and rich chalcopyrite-pyrrhotine ore subjected to flooding at the Oktyabrsky deposit in the Talnakh ore province. The analysis of the petrography, chemistry and mineralogy of the test samples showed no substantial differences in their properties after flooding. The comparison of the strength and deformation characteristics of rocks from the uniaxial compression and tension testing results demonstrate the decrease of both in water-saturated rocks and the increase in the room-temperature dried samples. The limit strength, elasticity modulus and internal friction angles have smaller values in rocks after drying than in the initial samples.
MODELING HYDRAULIC FRACTURING NEAR CIRCULAR UNDERGROUND OPENING IN TRIAXIAL COMPRESSION
Authors: АЗАРОВ А.В. , СЕРДЮКОВ С.В. 
Published: October 2024

Представлены результаты численных исследований распространения трещины гидроразрыва в неоднородно напряженной упругой среде вблизи цилиндрической полости. Моделирование выполнено расширенным методом конечных элементов. Рассмотрены разные варианты ориентации главных напряжений по отношению к полости и дисковому инициатору разрыва. Показано влияние соотношения напряжений и их уровня на траекторию развития трещин. Приведены основные типы образующихся трещин. Проанализированы условия, при которых гидроразрыв выходит на поверхность полости, распространяется вдоль нее. Описаны особенности изменения давления распространения и раскрытия трещин различной формы в зависимости от закаченного объема рабочей жидкости.
The article describes the numerical studies on propagation of hydraulic fracture in the nonuniform-stress elastic environment around a cylindrical cavity. The modeling used the extended method of finite elements. The scope of the modeling embraced different variants of the principal stress orientation relative to the cavity and a disk-shaped initiation fracture. The influence of the stress ratio and stress level on the fracture path is described. The main types of the created fractures are shown. The conditions when the created fracture reaches the cavity surface or propagates along it are analyzed. The features of the fracture propagation and opening pressure are described for the fractures of various shapes depending on the volume of the injection fluid.
MODELING ROCK FRACTURE IN CLOSELY SPACED PERIMETER BLASTING
Authors: ШЕР Е.Н. 
Published: October 2024

Приведены расчетная схема и результаты расчетов развития магистральных трещин, образующихся при взрыве сближенных шпуровых зарядов в хрупких горных породах. Расчеты в трехмерной постановке выполнены на примере образования щели в граните при контурном взрывании шпуров с зарядами аммонита для разных расстояний между шпурами и степени их заполнения взрывчатым веществом. Определены формы и размеры магистральных трещин, образующихся при взрыве одиночного шпурового заряда и трех сближенных. По результатам расчетов для конкретного шпурового заряда предложен способ определения рационального расстояния между шпурами при контурном взрывании, обеспечивающего максимальную площадь образующейся щели.
The article presents the design model and results for the main crack development in closely spaced blasting in brittle rocks. The 3D modeling is described as case-study of crack formation in granite in perimeter blasting of ammonite charges at different spacing and filling of blastholes. The shapes and sizes are determined for the main cracks generated by blasting of single charge and three close-spaced charges. From the modeling results obtained for a specific charge, the method is proposed to determine efficient spacing of blastholes in perimeter blasting to ensure the maximal area of the created crack.
INFLUENCE OF PROPPANT PARAMETERS ON HYDRAULIC FRACTURE CONDUCTIVITY
Authors: ЯН И. , ФУ Ц. , ЮАНЬ Х. , ХАЙДИНА М.П. , ВЭЙ Ц. 
Published: October 2024

Исследовано влияние параметров проппантов на долговременную проводимость трещин гидроразрыва пласта. Вдавливание проппантов в стенки трещины и их раздавливание изучены системой определения проводимости трещины FCMS-V с помощью автоэмиссионного сканирующего микроскопа, поляризационного микроскопа и методом ситового анализа. Выявлены зависимости проводимости от размера гранул, гранулометрического состава, концентрации и способа размещения проппантов, давления смыкания трещины и вдавливания проппантов в стенки трещины. Подробно рассмотрены вопросы вдавливания и раздавливания проппантов различного размера гранул под разным давлением смыкания трещины. Даны рекомендации по размещению проппантов при гидроразрыве пласта в условиях добычи метана угольных пластов на участке YC бассейна Ordos (Китай).
The authors analyze the influence of proppant parameter on the long-term conductivity of hydraulic fractures. Pressing of proppants in fracture walls and proppant smashing was studied using FCMS-V fracture conductivity system, field emission scanning electron microscope, polarization microscope and the sieve method. The correlations between the conductivity, grain size, grain-size composition, proppant concentration and placement technique, closure pressure of fractures and pressure of proppant pressing-in in the fracture walls are revealed. Pressing and smashing of proppant grains of different size under different closure pressure of fractures is discussed. The recommendations on proppant placement during hydraulic fracturing are given as a case study of methane recovery from coal seams in YC site of Ordos Basin in China.
STUDY ON BENEFICIATION TECHNOLOGY FOR RATIONAL UTILIZATION OF LOW-GRADE COPPER NICKEL SYMBIOTIC ORE
Authors: ГАНЬ Ф. , ГАО Л. , ДАЙ Х. , РАО Б. , БАЙ Ц. 
Published: October 2024

Рассмотрена методика рационального использования запасов бедных руд с низким содержанием меди и никеля. В результате минералогического анализа руды выявлено, что наиболее ценными элементами, входящими в состав руды, являются Cu и Ni, весовое содержание которых составляет 0.16 и 0.39 % соответственно. Основным медьсодержащим минералом является халькопирит, а основным никельсодержащим минералом - пентландит, в малом количестве распределенный в рудном сырье. Исходя из свойств руды, предложена следующая технология обогащения: одностадийное измельчение → основная коллективная медно-никелевая флотация → сепарация меди и никеля. В результате сепарации получен медный концентрат с массовым содержанием меди 17.08 % и никелевый концентрат с массовым содержанием никеля 4.63 %. Настоящая работа предлагает низкозатратное техническое решение для рационального использования полиметаллических парагенетических минеральных запасов.
In order to realize the rational utilization of low-grade polymetallic symbiotic mineral resources with low input, typical copper-nickel symbiotic low-grade ores were used as the test object. After careful process mineralogy research on the ore, it was learned that the main valuable elements of the ore were Cu and Ni, and the content of these two elements was 0.16 wt.% and 0.39 wt.%, respectively. The main copper-bearing mineral in the ore was chalcopyrite, and the main nickel-bearing mineral was pentlandite. Useful minerals were finely distributed in ores. Based on the properties of ore, a beneficiation process of one stage grinding → copper/nickel mixed flotation → copper/nickel separation was proposed. A copper concentrate with a Cu grade of 17.08 wt.% and a nickel concentrate with a Ni grade of 4.63 wt.% were obtained by separation. This study provides a low-investment technical solution for the rational utilization of polymetallic paragenetic mineral resources.