bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demographics, lifestyle and veterinary care of cats in Australia and New Zealand
Authors: Johnston Laura , Szczepanski Julia , McDonagh Phillip 
Published: February 2017

Objectives The aim of this survey was to provide up-to-date information on the demographics, lifestyle and veterinary care of cats in Australia and New Zealand. Methods An online survey consisting of 19 questions was created using SurveyMonkey. Cat owners were invited to participate through advertisements in veterinary clinics and social media. Results The average number of cats in a household was two. The majority of cats lived in free-standing houses (78%) in the suburbs (66%). The majority of cats were desexed (94% [49% female neutered; 45% male neutered]). A total of 57% of cats had been strays or came from an animal shelter. A total of 40% of owners had intended not to let the cats outside when they first acquired them. A total of 63% of cats were described as indoor–outdoor cats. Although owners described 34% of cats as ‘indoor only’, 58% of those cats had access to the outdoors. The majority of respondents’ cats were vaccinated annually (63%) and visited a vet at least annually (79%). The most common reasons to take a cat to the vet were vaccinations or the cat being unwell. The most common reasons not to regularly take the cat to the vet were that the cat was never unwell, cost or stress for the cat. Conclusions and relevance Consideration of the lifestyle of cats is important to optimise veterinary care. Cats across Australia and New Zealand have a variety of different and changing lifestyles. Therefore, careful owner questioning is required at each visit to maximise healthcare outcomes for cats.
Dosimetric Comparison of Real-Time MRI-Guided Tri-Cobalt-60 Versus Linear Accelerator-Based Stereotactic Body Radiation Therapy Lung Cancer Plans
Authors: Wojcieszynski Andrzej P. , Hill Patrick M. , Rosenberg Stephen A. , Hullett Craig R. , Labby Zacariah E. , Paliwal Bhudatt , Geurts Mark W. , Bayliss R. Adam , Bayouth John E. , Harari Paul M. , Bassetti Michael F. , Baschnagel Andrew M. 
Published: February 2017

Purpose: Magnetic resonance imaging–guided radiation therapy has entered clinical practice at several major treatment centers. Treatment of early-stage non-small cell lung cancer with stereotactic body radiation therapy is one potential application of this modality, as some form of respiratory motion management is important to address. We hypothesize that magnetic resonance imaging–guided tri-cobalt-60 radiation therapy can be used to generate clinically acceptable stereotactic body radiation therapy treatment plans. Here, we report on a dosimetric comparison between magnetic resonance imaging–guided radiation therapy plans and internal target volume–based plans utilizing volumetric-modulated arc therapy. Materials and Methods: Ten patients with early-stage non-small cell lung cancer who underwent radiation therapy planning and treatment were studied. Following 4-dimensional computed tomography, patient images were used to generate clinically deliverable plans. For volumetric-modulated arc therapy plans, the planning tumor volume was defined as an internal target volume + 0.5 cm. For magnetic resonance imaging–guided plans, a single mid-inspiratory cycle was used to define a gross tumor volume, then expanded 0.3 cm to the planning tumor volume. Treatment plan parameters were compared. Results: Planning tumor volumes trended larger for volumetric-modulated arc therapy–based plans, with a mean planning tumor volume of 47.4 mL versus 24.8 mL for magnetic resonance imaging–guided plans ( P = .08). Clinically acceptable plans were achievable via both methods, with bilateral lung V20, 3.9% versus 4.8% ( P = .62). The volume of chest wall receiving greater than 30 Gy was also similar, 22.1 versus 19.8 mL ( P = .78), as were all other parameters commonly used for lung stereotactic body radiation therapy. The ratio of the 50% isodose volume to planning tumor volume was lower in volumetric-modulated arc therapy plans, 4.19 versus 10.0 ( P < .001). Heterogeneity index was comparable between plans, 1.25 versus 1.25 ( P = .98). Conclusion: Magnetic resonance imaging–guided tri-cobalt-60 radiation therapy is capable of delivering lung high-quality stereotactic body radiation therapy plans that are clinically acceptable as compared to volumetric-modulated arc therapy–based plans. Real-time magnetic resonance imaging provides the unique capacity to directly observe tumor motion during treatment for purposes of motion management.
A Comparative Evaluation of 3 Different Free-Form Deformable Image Registration and Contour Propagation Methods for Head and Neck MRI: The Case of Parotid Changes During Radiotherapy
Authors: Broggi Sara , Scalco Elisa , Belli Maria Luisa , Logghe Gerlinde , Verellen Dirk , Moriconi Stefano , Chiara Anna , Palmisano Anna , Mellone Renata , Fiorino Claudio , Rizzo Giovanna 
Published: February 2017

Purpose: To validate and compare the deformable image registration and parotid contour propagation process for head and neck magnetic resonance imaging in patients treated with radiotherapy using 3 different approaches—the commercial MIM, the open-source Elastix software, and an optimized version of it. Materials and Methods: Twelve patients with head and neck cancer previously treated with radiotherapy were considered. Deformable image registration and parotid contour propagation were evaluated by considering the magnetic resonance images acquired before and after the end of the treatment. Deformable image registration, based on free-form deformation method, and contour propagation available on MIM were compared to Elastix. Two different contour propagation approaches were implemented for Elastix software, a conventional one (DIR_Trx) and an optimized homemade version, based on mesh deformation (DIR_Mesh). The accuracy of these 3 approaches was estimated by comparing propagated to manual contours in terms of average symmetric distance, maximum symmetric distance, Dice similarity coefficient, sensitivity, and inclusiveness. Results: A good agreement was generally found between the manual contours and the propagated ones, without differences among the 3 methods; in few critical cases with complex deformations, DIR_Mesh proved to be more accurate, having the lowest values of average symmetric distance and maximum symmetric distance and the highest value of Dice similarity coefficient, although nonsignificant. The average propagation errors with respect to the reference contours are lower than the voxel diagonal (2 mm), and Dice similarity coefficient is around 0.8 for all 3 methods. Conclusion: The 3 free-form deformation approaches were not significantly different in terms of deformable image registration accuracy and can be safely adopted for the registration and parotid contour propagation during radiotherapy on magnetic resonance imaging. More optimized approaches (as DIR_Mesh) could be preferable for critical deformations.
Eliglustat maintains long-term clinical stability in patients with Gaucher disease type 1 stabilized on enzyme therapy
Authors: Cox Timothy M. , Drelichman Guillermo , Cravo Renata , Balwani Manisha , Burrow Thomas Andrew , Martins Ana Maria , Lukina Elena , Rosenbloom Barry , Goker-Alpan Ozlem , Watman Nora , El-Beshlawy Amal , Kishnani Priya S. , Pedroso Maria Lucia , Gaemers Sebastiaan J. M. , Tayag Regina , Peterschmitt M. Judith 
Published: February 2017

Key Points
Eliglustat treatment resulted in stable mean hemoglobin concentration, platelet count, and spleen and liver volumes for up to 4 years. Mean bone mineral density z scores also remained stable and were maintained in the healthy reference range for up to 4 years.
Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage
Authors: Bot Christopher , Pfeiffer Annika , Giordano Fosco , Manjeera Dharani E. , Dantuma Nico P. , Ström Lena 
Published: February 2017

ABSTRACT
NIPBL is required to load the cohesin complex on to DNA. While the canonical role of cohesin is to couple replicated sister chromatids together until the onset of mitosis, it also promotes tolerance to DNA damage. Here, we show that NIPBL is recruited to DNA damage throughout the cell cycle via independent mechanisms, influenced by type of damage. First, the heterochromatin protein HP1γ (also known as CBX3) recruits NIPBL to DNA double-strand breaks (DSBs) through the corresponding HP1-binding motif within the N-terminus. By contrast, the C-terminal HEAT repeat domain is unable to recruit NIPBL to DSBs but independently targets NIPBL to laser microirradiation-induced DNA damage. Each mechanism is dependent on the RNF8 and RNF168 ubiquitylation pathway, while the recruitment of the HEAT repeat domain requires further ATM or ATR activity. Thus, NIPBL has evolved a sophisticated response to damaged DNA that is influenced by the form of damage, suggesting a highly dynamic role for NIPBL in maintaining genomic stability.
miR-450a-5p within rat adipose tissue exosome-like vesicles promotes adipogenic differentiation by targeting WISP2
Authors: Zhang Yan , Yu Mei , Dai Minjia , Chen Chang , Tang Qi , Jing Wei , Wang Hang , Tian Weidong 
Published: February 2017

ABSTRACT
Adipose tissue is an active endocrine organ that can secrete a wide number of factors to regulate adipogenesis via paracrine signals. In addition to soluble proteins in adipose tissue, microRNAs (miRNAs) enriched in extracellular vesicles (EVs), such as exosomes or microvesicles, could modulate intercellular communications. In this study, we demonstrated that exosome-like vesicles derived from adipose tissue (Exo-AT) were internalized by adipose tissue-derived stem cells (ADSCs), and that these, in turn, induced adipogenesis. High-throughput sequencing showed that 45 miRNAs were enriched in Exo-AT, and 31.11% of them were associated with adipogenesis, compared with ADSC-derived exosome-like vesicles (Exo-ADSC). miR-450a-5p, one of the most abundant miRNAs in Exo-AT, was a proadipogenic miRNA. Further study demonstrated that miR-450a-5p promoted adipogenesis through repressing expression of WISP2 by targeting its 3′ untranslated region. Additionally, Exo-AT could also downregulate the expression of WISP2, while miR-450a-5p inhibitor reversed this effect. Moreover, inhibition of miR-450a-5p impaired adipogenesis mediated by exosome-like vesicles. In conclusion, Exo-AT mediates adipogenic differentiation through a mechanism involving transfer of miR-450a-5p.
Ypk1 and Ypk2 kinases maintain Rho1 at the plasma membrane by flippase-dependent lipid remodeling after membrane stresses
Authors: Hatakeyama Riko , Kono Keiko , Yoshida Satoshi 
Published: February 2017

ABSTRACT
The plasma membrane (PM) is frequently challenged by mechanical stresses. In budding yeast, TORC2-Ypk1/Ypk2 kinase cascade plays a crucial role in PM stress responses by reorganizing the actin cytoskeleton via Rho1 GTPase. However, the molecular mechanism by which TORC2-Ypk1/Ypk2 regulates Rho1 is not well defined. Here, we found that Ypk1/Ypk2 maintain PM localization of Rho1 under PM stress via spatial reorganization of the lipids including phosphatidylserine. Genetic evidence suggests that this process is mediated by the Lem3-containing lipid flippase. We propose that lipid remodeling mediated by the TORC2-Ypk1/Ypk2-Lem3 axis is a backup mechanism for PM anchoring of Rho1 after PM stress-induced acute degradation of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], which is responsible for Rho1 localization under normal conditions. Since all the signaling molecules studied here are conserved in higher eukaryotes, our findings might represent a general mechanism to cope with PM stress.
Learning, gustatory responsiveness and tyramine differences across nurse and forager honeybees
Authors: Scheiner Ricarda , Reim Tina , Søvik Eirik , Entler Brian V. , Barron Andrew B. , Thamm Markus 
Published: February 2017

Honeybees are well known for their complex division of labor. Each bee sequentially performs a series of social tasks during its life. The changes in social task performance are linked to gross differences in behavior and physiology. We here tested whether honeybees performing different social tasks (nursing vs. foraging) would differ in their gustatory responsiveness and associative learning behavior in addition to their daily tasks in the colony. Further, we investigated the role of the biogenic amine tyramine and its receptors in the behavior of nurse bees and foragers. Tyramine is an important insect neurotransmitter, which has long been neglected in behavioral studies since it was believed to only act as the metabolic precursor of the better-known amine octopamine. With the increasing number of characterized tyramine receptors in diverse insects, we need to understand the functions of tyramine on its own account.
Our findings suggest an important role for tyramine and its two receptors in regulating honeybee gustatory responsiveness, social organization and learning behavior. Foragers, which were more responsive to gustatory stimuli than nurse bees and performed better in appetitive learning, also differed from nurse bees in their tyramine brain titers and in the mRNA expression of a tyramine receptor in the brain. Pharmacological activation of tyramine receptors increased gustatory responsiveness of nurse bees and foragers and improved appetitive learning in nurse bees. These data suggest that a large part of behavioral differences between honeybees may be directly linked to tyramine signaling in the brain.
Modelos animales de degeneración cognitiva y uso de transplantes neurales de células madre como terapia
Authors: Oliveira Alcyr Alves de , Bertuzzi Leticia , Santos da Silva Patricia , Fluck Pereira Neto Élida , Nicolaidis Rafael 
Published: February 2017

Existen pocos modelos animales de degeneración cognitiva que podrían ser considerados tan importantes como el modelo de lesión colinérgica de la enfermedad de Alzheimer. La enfermedad de Alzheimer es una patología neurodegenerativa asociada con el envejecimiento y con degeneración cognitiva acentuada y progresiva. Sus complejas y múltiples vías neurales secuenciales pueden conducir a la comprensión de que las intervenciones de agente único pueden ser insuficiente para impactar el curso de esta enfermedad. El tratamiento farmacológico actual es paliativo y, aunque pueda retardar el progreso de la enfermedad, no es capaz de ofrecer una cura. La combinación de drogas y sustancias antioxidantes han sido investigadas, sin embargo, existen pocos estudios que demuestran resultados consistentes basados en esta presunción. Así, el objetivo de este artículo fue destacar las terapias basadas en la reposición celular como potencial tratamiento para enfermedades del sistema nervioso periférico y central.
Sharing Aggregate Inventory Information with Customers: Strategic Cross-Selling and Shortage Reduction
Authors: Cui Ruomeng , Shin Hyoduk 
Published: February 2017

This paper studies the strategy of sharing inventory information for a firm that sells two vertically differentiated products. The seller has private information on the aggregate inventory level and the inventory composition of two product variants. The seller credibly and discretionarily discloses inventory information to customers either fully or partially, i.e., disclosing the exact inventory of each product variant, the aggregate inventory level, or no information to customers. Customers form expectations of future availability and make rational purchasing decisions accordingly. In the disclosure literature, discretion usually leads to an unraveling result: sellers who learn favorable market information opt to disclose it, making full disclosure the equilibrium. This paper shows that aggregate inventory disclosure, i.e., partial disclosure, can be instead sustained as an ex post equilibrium. We demonstrate that inventory information aggregation arises when there is an ex post desire to reduce supply–demand mismatches in all inventory scenarios. Specifically, when customers’ preferred products are more likely to stock out, the seller could entice more incoming consumers who hope that their desired products are in stock by withholding product composition but disclosing the aggregate inventory level. If customers’ desired products are sold out, the seller can benefit from upselling or cross-selling customers’ less preferred products. Alternatively, when the seller stocks more desired products, aggregate disclosure can dampen the flow of incoming customers and reduce the shortage penalty cost. This result is robust under various settings: risk-averse customers, heterogeneous customers, and horizontally differentiated products. This paper was accepted by Serguei Netessine, operations management.
Tailoring nirvana: Appropriating yoga, resignification and instructional challenges
Authors: Antony Mary Grace 
Published: February 2017

Abstract
As an appropriated cultural artefact, yoga provides the opportunity to examine how resignification alters instructional goals and outcomes. This project critically examines instructional challenges experienced by non-Indian yoga teachers, with an emphasis on how resolving these issues impacts pedagogical relationships. Findings demonstrate that student preferences require instructors to resignify yoga instruction within three areas: replacing Sanskrit nomenclature with more relatable terminology; highlighting the physiological (rather than religio-spiritual) benefits; and varying asana routines to discourage boredom. Together, these themes overlap and reinforce one another to ideologically rearticulate yoga as fitness and physical therapy, and thus discursively shift the focus of yoga practice from text/artefact (yoga) to consumer (student).
Cola millenii Leaf Ethyl Acetate Extract: Fourier Transform Infrared (FTIR) Spectroscopy; Modulatory Effect on Serum Indices and Redox Biomarkers
Authors: Itoandon E. E. , Nwachukwu V. A. , Erukainure O. L. , Lasore O. O. , Nwagala P. N. 
Published: February 2017

AbstractThe ethyl acetate extract of the leaves of Cola millenii were investigated for it secondary metabolites as well as its effect on serum indices and antioxidant status in normal male albino rats. Fresh leaves of C. millenii were air dried, extracted with ethyl acetate and concentrated. The extract was analysed for its secondary metabolites using the Fourier transform infrared (FTIR) spectroscopy. Three concentrates consisting of 50, 100, and 200 mg/kg body weight (bw) of the extract were prepared. Groups of five rats were intraperitoneally injected with each of the doses, whilst a fourth group was not injected and served as the normal control. After 7 days, the rats were sacrificed by cervical dislocation. Blood serum was analysed for hepatic and renal biomarkers as well as cholesterol level. Hepatic tissue was analysed for malondialdehyde (MDA) level, superoxide dismutase (SOD) and catalase (CAT). FITR spectroscopy revealed the presence of aliphatic, carboxylic acids, esters and alkenes functional groups. Administration of the extract doses led to the increased serum activities of hepatic and renal biomarkers. About 50 mg/kg bw of the extract had the least cholesterol level compared to the other doses. MDA level was significantly (p < 0.05) reduced in rats administered with 50 mg/kg bw of the extract. Except for the lowest dose, little or no significant effect was observed on SOD and CAT activities. These results indicate the medicinal potential of ethyl acetate extract of C. millenii leaves as portrayed by the low cholesterol and MDA levels and increased CAT activity with 50 mg/kg bw being the most active concentration.
Reconsidering the rigour-relevance gap: the need for contextualised research in risk societies
Authors: Galavan Robert J. , Harrington Denis , Kelliher Felicity 
Published: February 2017

Abstract
This paper addresses the debate on rigour and relevance in management research to identify barriers to progress and identify the challenges and opportunities in moving forward. We identify strong calls from both North American and European literatures for a move to close this gap. It has, however, been 20 years since Hambrick asked scholars ‘What if the academy actually mattered?’ during his Presidential address to the Academy of Management. Despite both the time and the consistency of calls, there has been only modest progress in closing this rigour-relevance gap. We argue that this is not because of any lack of willingness or capacity but is shaped by systemic issues. We find the narrative of the business school framed as either professional or social sciences a core issue. Each brings with them a tradition of different ontological perspectives and epistemological processes, protected by gatekeepers, which supports, even if unintentionally, the maintenance of the gap. We go on to discuss the challenge of management education and research in a postmodern context, the need to examine our conception of rigour, and to challenge the definition of management as a profession given its strategic win-lose orientation. We conclude with a discussion on the relationship between society and business and lay out the challenges ahead for richly contextualised scholarly work that may be defined as both rigorous and relevant.
Language planning for Malay in Malaysia: A case of failure or success?
Authors: Coluzzi Paolo 
Published: February 2017

AbstractThis article looks at the language planning that has been carried out since Independence in Malaysia for the promotion of Malay, the national language. After a sociolinguistic outline of the country, the different phases language planning is normally divided into are examined in detail, highlighting both the points that have proven to be successful and those that have not. In the second part of the article the problems that have been encountered during language planning and the reasons why Malay has not succeeded in becoming a full-blown national language which even the non-Malays can identify with are examined. Together with the problems, some possible solutions are put forward that may improve the given situation and make Malay a useful and prestigious language also for the non-Malays, who make up more than one third of the total population, and perhaps even internationally.
Malaysian Mandarin variation with regard to Mandarin globalization trend: Issues on language standardization
Authors: Khoo Kiak Uei 
Published: February 2017

AbstractMalaysian Mandarin is a unique variation of Mandarin that exhibits certain degrees of variation as opposed to Putonghua, the standardized Mandarin spoken in Mainland China. Following the spread of Putonghua under the Mandarin globalization trend, the issue of language standardization has become a central concern among the Chinese Malaysian community. This article examines the central principles of language standardization and thus gives suggestions to the proper and workable strategies needed for managing the Malaysian Mandarin variations. By these principles, in addition to an analysis of issues within Malaysian Mandarin standardization, this article proposes, through illustration of lexical standardization, a flexible and dynamic approach to setting strategies for standardization of Malaysian Mandarin with regard to the Mandarin globalization trend.