bluuebunny/crossref_metadata_2025_split huggingface dataset:
NUCLEAR FACTOR Y, subunit C (NF-YC) transcription factors are positive regulators of photomorphogenesis inArabidopsis thaliana
Authors: Myers Zachary A. , Kumimoto Roderick W. , Siriwardana Chamindika L. , Gayler Krystal K. , Risinger Jan R. , Pezzetta Daniela , Holt Ben F. 
Published: August 2016

AbstractRecent reports suggested that NF-Y transcription factors are positive regulators of skotomorphogenesis inArabidopsis thaliana. ThreeNF-YCgenes (NF-YC3, NF-YC4, andNF-YC9) are known to have overlapping functions in photoperiod dependent flowering and previous studies demonstrated that they interact with basic leucine zipper (bZIP) transcription factors. This included ELONGATED HYPOCOTYL 5 (HY5), which has well-demonstrated roles in photomorphogenesis. Similar tohy5mutants, we report thatnf-yc3 nf-yc4 nf-yc9triple mutants failed to inhibit hypocotyl elongation in all tested light wavelengths. Surprisingly,nf-yc3 nf-yc4 nf-yc9 hy5mutants had synergistic defects in light perception, suggesting that NF-Ys represent a parallel light signaling pathway. As with other photomorphogenic transcription factors,nf-yc3 nf-yc4 nf-yc9triple mutants also partially suppress the short hypocotyl and dwarf rosette phenotypes of CONSTITUTIVE PHOTOMORPHOGENIC 1 (cop1) mutants. Thus, our data strongly suggest that NF-Y transcription factors have important roles as positive regulators of photomorphogenesis, and in conjunction with other recent reports implies that the NF-Y are multifaceted regulators of early seedling development.Author SummaryLight perception is critically important for the fitness of plants in both natural and agricultural settings. Plants not only use light for photosynthesis, but also as a cue for proper development. As a seedling emerges from soil it must determine the light environment and adopt an appropriate growth habit. When blue and red wavelengths are the dominant sources of light, plants will undergo photomorphogenesis. Photomorphogenesis describes a number of developmental responses initiated by light in a seedling, and includes shortened stems and establishing the ability to photosynthesize. The genes regulating photomorphogenesis have been studied extensively, but a complete picture remains elusive. Here we describe the finding that NUCLEAR FACTOR-Y (NF-Y) genes are positive regulators of photomorphogenesis - i.e., in plants where NF-Y genes are mutated, they display some characteristics of dark grown plants, even though they are in the light. Our data suggests that the roles of NF-Y genes in light perception do not fit in easily with those of other described pathways. Thus, studying these genes promises to help develop a more complete picture of how light drives plant development.
Cancer treatment scheduling and dynamic heterogeneity in social dilemmas of tumour acidity and vasculature
Authors: Kaznatcheev Artem , Velde Robert Vander , Scott Jacob G. , Basanta David 
Published: August 2016

AbstractBackgroundTumours are diverse ecosystems with persistent heterogeneity in various cancer hallmarks like self-sufficiency of growth factor production for angiogenesis and reprogramming of energy-metabolism for aerobic glycolysis. This heterogeneity has consequences for diagnosis, treatment, and disease progression.MethodsWe introduce the double goods game to study the dynamics of these traits using evolutionary game theory. We model glycolytic acid production as a public good for all tumour cells and oxygen from vascularization via VEGF production as a club good benefiting non-glycolytic tumour cells. This results in three viable phenotypic strategies: glycolytic, angiogenic, and aerobic non-angiogenic.ResultsWe classify the dynamics into three qualitatively distinct regimes: (1) fully glycolytic, (2) fully angiogenic, or (3) polyclonal in all three cell types. The third regime allows for dynamic heterogeneity even with linear goods, something that was not possible in prior public good models that considered glycolysis or growth-factor production in isolation.ConclusionThe cyclic dynamics of the polyclonal regime stress the importance of timing for antiglycolysis treatments like lonidamine. The existence of qualitatively different dynamic regimes highlights the order effects of treatments. In particular, we consider the potential of vascular renormalization as a neoadjuvant therapy before follow up with interventions like buffer therapy.
Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pairs
Authors: Vatansever Sezen , Gümüş Zeynep H. , Erman Burak 
Published: August 2016

SummaryWhile mutant K-Ras is an important therapeutic target for human cancers, there are still no drugs that directly target it. Recent promising studies emphasize the significance of dynamics data to selectively target its active/inactive states. However, despite tremendous information on K-Ras, the direction of information flow in the allosteric regulation of its dynamics has not yet been elucidated. Here, we present a novel approach that identifies causality in correlated motions of proteins and apply it to K-Ras dynamics. Specifically, we analyze molecular dynamics simulations data and comprehensively investigate nucleotide-dependent intrinsic K-Ras activity. We show that GTP binding leads to characteristic residue correlations with relatively long decay times by stabilizing K-Ras motions. Furthermore, we identify for the first time driver-follower relationships of correlated motions in the regulation of K-Ras activity. Our results can be utilized for directly targeting mutant K-Ras in future studies.
Evolutionary Fates and Dynamic Functionalization of Young Duplicate Genes in Arabidopsis Genomes
Authors: Wang Jun , Tao Feng , Marowsky Nicholas C. , Fan Chuanzhu 
Published: August 2016

AbstractGene duplication is a primary means to generate genomic novelties, playing an essential role in speciation and adaptation. Particularly in plants, a high abundance of duplicate genes has been maintained for significantly long periods of evolutionary time. To address the manner in which young duplicate genes were derived primarily from small-scale gene duplication and preserved in plant genomes and to determine the underlying driving mechanisms, we generated transcriptomes to produce the expression profiles of five tissues in Arabidopsis thaliana and the closely related species Arabidopsis lyrata and Capsella rubella. Based on the quantitative analysis metrics, we investigated the evolutionary processes of young duplicate genes in Arabidopsis. We determined that conservation, neofunctionalization, and specialization are three main evolutionary processes for Arabidopsis young duplicate genes. We explicitly demonstrated the dynamic functionalization of duplicate genes along the evolutionary time scale. Upon origination, duplicates tend to maintain their ancestral functions; but as they survive longer, they might be likely to develop distinct and novel functions. The temporal evolutionary processes and functionalization of plant duplicate genes are associated with their ancestral functions, dynamic DNA methylation levels, and histone modification abundances. Furthermore, duplicate genes tend to be initially expressed in pollen and then to gain more interaction partners over time. Altogether, our study provides novel insights into the dynamic retention processes of young duplicate genes in plant genomes.
Surveying innovation in samples of individual end consumers
Authors: de Jong Jeroen P.J. 
Published: August 2016

Purpose– Rather than businesses, individual end consumers may develop innovations for themselves. Innovating consumers generally do not protect their innovations with intellectual property rights and may be generally available – a phenomenon recently coined as “free innovation” (von Hippel, 2016). The purpose of this paper is to take stock of how innovation by individual consumers has been measured, and to propose a survey procedure for future studies of consumer innovation.Design/methodology/approach– The author provides a literature review of how innovation by individual end consumers has been measured, and reports on a pilot study conducted in Finland to improve and standardize the measurement of consumer innovation.Findings– The survey procedure includes up to six steps which can be tailored to specific research purposes.Originality/value– The procedure will enable better international/cross-study comparisons and an efficient collection of data.
Modelling student satisfaction and motivation in the integrated educational environment
Authors: Stukalina Yulia 
Published: August 2016

Purpose– The purpose of this paper is to explore some issues related to enhancing the quality of educational services provided by a university in the agenda of integrating quality assurance activities and strategic management procedures.Design/methodology/approach– Employing multiple regression analysis the author has examined some factors that are supposed to have an impact on student satisfaction and student motivation in the integrated educational environment.Findings– The results of the two-phase empirical research performed in two higher education institutions indicate that student satisfaction and student motivation can be modelled on a number of predictors, which are associated with several indicators related to various aspects of the integrated educational environment.Research limitations/implications– The sample in this study included two higher education institutions. Future study with a more diverse student population and the refined scale items is recommended to verify and generalize the findings.Practical implications– The research provides useful data for addressing some critical issues in the context of integrating quality assurance activities and strategic management procedures in a university. The results of the empirical study suggest that education managers might carry out regular assessment of their educational environment in the framework of performing strategic analysis, which is aimed at quality enhancement, in order to determine the most significant aspects and associated influences. This would allow them to focus their efforts, time and resources on the issues with the greatest potential for having an impact on the university’s operations, and which may be related to providing qualitative changes in the educational environment in the frame of implementing a number of competitive strategies.Originality/value– The relevant literature analysis has allowed the author to explore the research topic from a new (holistic) perspective, and to consider both student satisfaction and student motivation in the integrated educational environment, which was viewed as a complicated multi-level system. In this respect, being related to approaches, ideas and findings in the existing literature, the paper presents an attempt to develop these further in terms of adding value to previous research. The obtained information can be of interest to managers working in the area of higher education.
Exploring academics’ approaches to managing team assessment
Authors: Augar Naomi , Woodley Carolyn J , Whitefield Despina , Winchester Maxwell 
Published: August 2016

Purpose– The purpose of this paper is to develop an understanding of academics’ approaches to managing team assessment at an Australian University with a view to informing policy development and assessment design.Design/methodology/approach– The research was conducted using a single exploratory case study approach focussing on the team assessment approach of academics teaching in two colleges at an Australian University. A desktop audit of publicly available assessment policy from 38 Australian universities was conducted alongside a review of relevant college subject guides. The findings of this review framed a subsequent focus group and online survey of academic staff.Findings– Results suggest that staff have adopted highly diverse and idiosyncratic approaches to team assessment and have mixed views about varied approaches to managing and assessing teamwork. Findings identify a need for explicit guidance and professional development on designing, managing and grading team assessments. Institutional limits and criteria should be introduced to ensure a whole-of-course approach to developing teamwork skills and ensure students are not burdened with an excessive number of team assessment tasks in a degree.Research limitations/implications– The paper reports results from an exploratory case study at a single Australian University. As such, the results are not generalizable.Practical implications– The findings could inform guidelines, policies or support resources for designing team assessment tasks.Originality/value– The research explores a challenging area for academics: team assessment, which the research indicates is not currently adequately managed through university policy and procedure. The findings highlight options for universities to consider when developing policies and procedures to manage team assessment. The study also provides recommendations for academics to consider when developing and managing team assessment.
School discipline, school uniforms and academic performance
Authors: Baumann Chris , Krskova Hana 
Published: August 2016

Purpose
– The purpose of this paper is to examine the role of school discipline in achieving academic performance. The study aims to clarify the role of permissive vis-à-vis authoritative teaching styles with an overarching hypothesis that better discipline leads to better academic performance. The authors also probe whether uniformed students have better discipline.

Design/methodology/approach
– The authors analyse Organisation for Economic Co-operation and Development’s Programme for International Student Assessment data on school discipline dimensions: students listening well, noise levels, teacher waiting time, students working well, class start time. Analysis of variance (ANOVA) with post hoc analysis on five geographic groups established by Baumann and Winzar (2016) was applied to test for geographic differences (Europe, Americas, Far East Asia, Rest of Asia, Anglo-Saxon cluster) in school discipline. ANOVA was further used to test for school discipline and academic performance. Third, t-tests on five discipline dimensions were run to test for differences between students who wear uniforms and those who do not.

Findings
– The results demonstrate differences in school discipline across five geographic clusters, with East Asia leading the way. The authors demonstrate significant differences in discipline for low, medium and high performing students. Peak-performing students have the highest level of discipline. Students wearing a uniform listen better with lower teacher waiting times.

Originality/value
– Students peak perform when teachers create a disciplined atmosphere where students listen to teachers, where noise levels in the classroom are low and they do not have to wait to start class and teach. Good discipline allows students to work well and this ultimately leads to better academic performance. Uniforms contribute to better discipline in everyday school operations. The findings support that in general, implementing school uniforms at schools might enhance discipline and allow for better learning. The authors recommend keeping uniforms where they are already used and to consider introducing uniforms where they are not yet common.
Beyond the marginalization thesis
Authors: Williams Colin C , Horodnic Ioana Alexandra 
Published: August 2016

Purpose– Grounded in an emergent recognition that those people in formal employment conduct the vast majority of work in the shadow economy, the purpose of this paper is to evaluate for the first time the degree to which shadow work is conducted by those in formal jobs and the characteristics of those in formal employment who participate in the shadow economy.Design/methodology/approach– To do this, the authors report a 2007 survey of participation in the shadow economy involving 26,659 face-to-face interviews conducted in 27 European Union (EU) member states.Findings– The finding is that in the EU, the formally employed undertake a disproportionate share of work in the shadow economy. Analysing the characteristics of the employed most likely to work in the shadow economy, however, it is those who benefit least from the formal economy, namely, younger unmarried men and on lower incomes living in rural areas, working in the construction sector and in small firms.Research limitations/implications– The outcome is a tentative call for recognition that although people in formal employment conduct the vast majority of work in the shadow economy, these are mostly particular vulnerable and weaker groups of the formally employed. Whether similar findings prevail at other spatial scales and in other global regions now needs investigating.Practical implications– This survey displays the need for policy not to target the unemployed but particular groups of the formally employed.Originality/value– The first extensive evaluation of the extent to which shadow work is conducted by those in formal jobs and the characteristics of those in formal employment who participate in the shadow economy.
Integrated care transitions: emergency to primary health care
Authors: Day Carolina Baltar , Witt Regina Rigatto , Oelke Nelly D 
Published: August 2016

Purpose
– The purpose of this paper is to focus on the Integrated Care Transitions Project between the emergency department (ED) of a university hospital and primary health care (PHC) services in a large city in Southern Brazil was the focus of this study. Care transitions occurred through telephone contact for patients discharged from the ED to PHC.

Design/methodology/approach
– This descriptive, exploratory qualitative research collected data via semi-structured interviews (n=14) including interns of health disciplines, advisors for interns, nurses, and physicians from the ED and PHC Family Unit. A thematic analysis of the data were conducted.

Findings
– ED providers felt they gained increased knowledge of the care networks available for patients in the community. Connection between the providers in ED and PHC facilitated confidence in the services provided in the community and increased continuity of care for patients’ needs. The PHC providers recognized integration promoted communication and better care planning for patients discharged from ED. Integrated care made the work in the PHC easier and benefited the users.

Research limitations/implications
– The study evaluated a program available in one hospital. Generalizability may be limited as services in the ED were provided by professional residents and their advisors, not employees of the hospital.

Practical implications
– Shared information by different health services leads to better care for patients and greater job satisfaction for providers.

Originality/value
– Care transitions are not well-managed in health care; there is limited research focusing on care transitions from ED to community. For providers and patients, this program assisted in building capacity and networks for transitions in care.
Ba virtual and inter-organizational evolution: a case study from a EU research project
Authors: Bartolacci Chiara , Cristalli Cristina , Isidori Daniela , Niccolini Federico 
Published: August 2016

Purpose
Taking Nonaka’s SECI model as the main reference, this paper aims to offer reflections on the virtual evolution of ba, the places for knowledge creation. Indeed, looking at the current scenario, widening the knowledge spiral to the inter-organizational epistemological level is inevitable. To this aim, information technology tools and virtual communities can establish effective interactions to exchange knowledge, making ba evolve congruently.

Design/methodology/approach
The paper takes the exemplary case of a platform developed during a European research project called “BIVEE: Business Innovation in Virtual Enterprise Environments”. The investigative approach chosen is participatory action research (PAR), with two researchers conducting PAR in real time, and two others involved ex post.

Findings
The paper shows that the virtual evolution of ba can lead the SECI model towards an inter-organizational level. Moreover, through a learning history, it describes how all the phases of the SECI process, even the Socialization one, can take place or be supported in virtual spaces.

Research limitations/implications
Taking into account just one single exemplary case study provides a rich, contextualized understanding of phenomena, while allowing only some theoretical generalizations.

Originality/value
This paper contextualizes the SECI model within a Web platform for open innovation, to investigate whether the knowledge creation process can take place entirely within a virtual environment linking subjects from different organizations. In so doing, it applies the SECI model to the phases of the innovation process, called waves.
Innovation in service ecosystems
Authors: Aal Kotaiba , Di Pietro Laura , Edvardsson Bo , Renzi Maria Francesca , Guglielmetti Mugion Roberta 
Published: August 2016

Purpose– The purpose of this paper is to extend the understanding of innovation in service ecosystems by focussing on the role of values resonance in relation to the integration of brands, service systems and experience rooms.Design/methodology/approach– An empirical, explorative case study of an innovative service system is carried out using a narrative approach and presented in the form of a saga.Findings– Insights gleaned from the empirical study are used for conceptual developments. Analysis of the empirical case study is presented as four lessons linked to values, brands, service systems and experience rooms.Originality/value– The paper extends a conceptual framework of innovative resource integration in service ecosystems. The paper also contributes four propositions to inform theory: values resonance is a basis for service innovation, the innovative integration of brands based on values resonance can foster innovation, the integration of resources across service system boundaries grounded in values resonance can enable innovation and the integration of experience rooms into a coherent servicescape based on values resonance can support novel forms of resource integration and value co-creation efforts in service ecosystems.
Perceived prevalence and personal impact of negative online reviews
Authors: Bradley Graham L. , Sparks Beverley A. , Weber Karin 
Published: August 2016

Purpose
– Technological advancement and growth in social media have meant that customers are increasingly using the internet to write a review or express opinions about products and services. Many of these online reviews are critical of service organizations and workers. The purpose of this paper is to document the experiences that service industry personnel have of negatively valenced, customer-authored, online reviews, the personal impact of these reviews, and the manner in which participants respond emotionally and behaviorally to these reviews.

Design/methodology/approach
– This research drew on the stress, coping, and service literature, with particular emphasis on stress appraisal theory. The study involved the completion of an anonymous online questionnaire by 421 restaurant owners, managers, and employees.

Findings
– Many respondents reported feelings of anger and use of maladaptive coping strategies in response to negative online reviews (NORs). Smaller numbers reported feelings of embarrassment and guilt, and thoughts of leaving the industry. Factors pertaining to respondents’ online review exposure, emotional responses, and coping strategies predicted the effects of negative reviews on thoughts of exiting current employment.

Research limitations/implications
– The findings have implications for protecting worker well-being and job tenure in an industry deeply affected by electronic word-of-mouth. Replication is recommended using a longitudinal design and more objective data obtained from validated instruments and independent sources.

Originality/value
– This survey provides the first known evidence of the personal impact of NORs on business owners, managers, and employees.