bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dementia‐Friendly Hospital—The Perspective of Professional Dementia Experts
Authors: Manietta Christina , Purwins Daniel , Pinkert Christiane , Fink Lisa , Rommerskirch‐Manietta Mike , Feige Melanie , Knecht Christiane , Roes Martina 
Published: September 2024

ABSTRACTAimTo investigate the professional dementia experts' understanding of a dementia‐friendly hospital to identify its characteristics.DesignWe used a qualitative design embedded in a case study. A total of 16 semi‐structured expert interviews were conducted with 17 professional dementia experts. Using inductive content analysis, the interviews were analysed in a participatory manner involving a group of researchers and dementia experts.ResultsWe identified six characteristics of dementia‐friendly hospitals: Proud to be dementia‐friendly—That's what we want; Seeing the human being—Taking care of everyone; Having everyone on board—It's a collective task; Being professional—It takes more than being nice and kind; Rethinking the ‘running’ system—We have to change, not them; and Being part of the community—Thinking beyond the hospital.ConclusionThe concept of a dementia‐friendly hospital seems complex and requires a rethinking of the traditional hospital. For a conceptualisation, the involvement of people with dementia and their relatives is important to gain a comprehensive understanding.Implications for the Profession and Patient CareA dementia‐friendly hospital is characterised by professional care that comprises a safe, familiar and supportive environment, is prepared but also flexible, has everyone on board, and sees the human being. To become dementia‐friendly, individual interventions such as training courses can be a starting point. However, an overall concept is required that also includes components that contribute to successful implementation and a welcoming culture of people with dementia.ImpactOur findings on the perspective of professional dementia experts contribute to the conceptualisation of dementia‐friendly hospitals.Reporting MethodWe reported our study according to the COREQ checklist.Patient and Public ContributionThe investigation of the perspective of professional dementia experts is one part of a larger study. In this overall DEMfriendlyHospital study, we interviewed professional dementia experts, people with dementia and their relatives and also involved them in a participatory manner in various stages of the research process.
Exploring the Experiences and Perceptions of the Utilisation of Structured Clinical Handover Frameworks by Nurses Working in Acute Care Settings: A Scoping Review
Authors: Moyo Patience , Anderson Judith , Francis Karen , Biles Jessica 
Published: September 2024

ABSTRACTBackgroundThere is increased interest in implementing structured clinical handover frameworks to improve clinical handover processes. Research postulates that structured clinical handover frameworks increase the quality of handovers; yet inconsistencies enacting these frameworks exist which has a potential to jeopardise the quality of communication during handovers thereby defeating the purpose of these frameworks.AimThis scoping review aims to analyse and synthesise what is currently known of the nurses' experiences and perceptions in implementing structured clinical handover frameworks and identify knowledge gaps in relation to this topic area.DesignA scoping review guided by the PRISMA‐ScR checklist.MethodsA systematic search of five electronic databases was undertaken to identify peer‐reviewed primary research studies which met the predetermined eligibility criteria. In total, 301 studies were imported into COVIDENCE, screened and assessed for eligibility resulting in 23 studies remaining. From the eligible studies, data was extracted, collated, appraised, summarised and interpreted.Data SourcesMEDLINE, CINHAL, ProQuest, EMCARE, Web of Science and Informit.ResultsTwenty three studies were included in this review which yielded the following major themes: (1) quality and completeness of information transfer; (2) interprofessional collaboration; (3) challenges impacting the experience of implementing the structured clinical handover frameworks and (4) perceived impacts on quality, patient safety and health outcomes.ConclusionThere are key benefits and issues experienced and perceived by nurses implementing structured clinical handover frameworks and this review identifies opportunities for further improvements. Future research should explore the perceived associations with patient outcomes.Relevance to Clinical PracticeThis review highlights the importance of structured clinical handover frameworks, the nurses' experiences in implementing these frameworks and strategies to improve the effectiveness of these frameworks.Patient or Public ContributionsNo Patient or Public Contributions as this study is a review of published primary evidence.
Placental growth factor alleviates hyperglycemia‐induced trophoblast pyroptosis by regulating mitophagy
Authors: Tao Jun , Rao Yuzhu , Wang Jingjing , Tan Shiming , Zhao Jinli , Cao Zitong , He Lu , Meng Jun , Wu Peng , Wang Zuo 
Published: September 2024

AbstractIntroductionHyperglycemia is closely related to trophoblast dysfunction during pregnancy and results in suppressed invasion, migration, and pro‐inflammatory cell death of trophoblasts. Hyperglycemia is a dependent risk factor for gestational hypertension accompanied by decreased placental growth factor (PLGF), which is important for maternal and fetal development. However, there is currently a lack of evidence to support whether PLGF can alleviate trophoblast cell dysfunction caused by high blood sugar. Here, we aim to clarify the effect of hyperglycemia on trophoblast dysfunction and determine how PLGF affects this process.MethodsThe changes in placental tissue histomorphology from gestational diabetes mellitus (GDM) patients were compared with those of normal placentas. HTR8/SVneo cells were cultured in different amounts of glucose to examine cellular pyroptosis, migration, and invasion as well as PLGF levels. Furthermore, the levels of pyroptosis‐related proteins (NLRP3, pro‐caspase1, caspase1, IL‐1β, and Gasdermin D [GSDMD]) as well as autophagy‐related proteins (LC3‐II, Beclin1, and p62) were examined by Western blotting. The GFP‐mRFP‐LC3‐II system and transmission electron microscopy were used to detect mitophagy levels, and small interfering RNAs targeting BCL2 Interacting Protein 3 (siBNIP3) and PTEN‐induced kinase 1 (siPINK1) were used to determine the role of mitophagy in pyroptotic death of HTR‐8/SVneo cells.ResultsOur results show that hyperglycemia upregulates NLRP3, pro‐caspase1, caspase1, IL‐1β at the protein level in GDM patients. High glucose (HG, 25 mM) inhibits viability, invasion, and migration of trophoblast cells while suppressing superoxide dismutase levels and promoting malondialdehyde production, thus leading to a senescence associated beta‐gal‐positive cell burst. PLGF levels in nucleus and the cytosol are also inhibited by HG, whereas PLGF treatment inhibited pyroptosis‐related protein levels of NLRP3, pro‐caspase1, caspase1, IL‐1β, and GSDMD, Gasdermin D N‐terminal domain (GSDMD‐N). HG‐induced mitochondrial dysfunction and BNIP3 and PINK1/Parkin expression. Knocking down BINP3 and PINK1 abolished the protective role of PLGF by preventing mitophagy.ConclusionPLGF inhibited hyperglycemia, while PLGF reversed hyperglycemic injury by promoting mitophagy via the BNIP3/PINK1/Parkin pathway. Altogether, these results suggest that PLGF may protect against trophoblast dysfunction in diabetes.
The Association Between the Central Sensitisation Inventory and Temporomandibular Disorders Is Confounded by Migraine, Depression, Widespread Pain and Parafunction. A Cross‐Sectional Telehealth Study
Authors: Calixtre Letícia Bojikian , van der Meer Hedwig Aleida , Visscher Corine Mirjam , de Oliveira Ana Beatriz , de Godoi Gonçalves Daniela Aparecida 
Published: September 2024

ABSTRACTBackgroundTemporomandibular disorders (TMDs) are conditions that involve the temporomandibular joints, masticatory muscles, and associated tissues, causing orofacial pain. Central sensitisation (CS) is a relevant part of the TMD pathophysiology. Migraine, psychological aspects, parafunctional oral habits and widespread pain are commonly associated with both TMD and CS and could confound the association between them.ObjectivesTo investigate the association between painful TMD and the Central Sensitisation Inventory (CSI) score, and to assess the presence of confounders in this association.MethodsCross‐sectional study that assessed women with and without orofacial pain complaints using telehealth. The TMD Pain Screener and an online physical examination determined the presence of painful TMD. The following questionnaires were applied: CSI, Headache Screening Questionnaire, Generalized Anxiety Disorder‐7, Patient Health Questionnaire‐9, Oral Behavior Checklist, Jaw Functional Limitation Scale and the Nordic musculoskeletal questionnaire. A single regression investigated the association between the CSI score and TMD, and a multiple regression investigated the effect of the other outcomes as possible confounders. Confounding was considered present when the association between TMD and the CSI score changed more than 10% after adding a possible confounder to the regression model.ResultsForty‐two women with painful TMD and 53 without TMD were included. There was a significant association between the CSI score and the presence of painful TMD (R2 = 0.639; p < 0.001). This association changed when the following outcomes were added to the model: presence of migraine, symptoms of depression, widespread pain and parafunctional oral habits.ConclusionThe positive association between TMD and the CSI score was confounded by migraine, symptoms of depression, widespread pain and parafunctional oral habits.
Exploring the Relationship Between Somatisation, Facial Pain and Psychological Distress in East Asian Temporomandibular Disorder Patients
Authors: Yap Adrian Ujin , Kim Sunghae , Jo Jung Hwan , Lee Byeong‐min , Park Ji Woon 
Published: September 2024

ABSTRACTObjectivesThe relationship of somatisation with facial pain duration/intensity, pain‐related interference/disability and psychological distress was investigated in East Asian temporomandibular disorder (TMD) patients. Correlations between somatisation, facial pain and psychological characteristics were also explored alongside the demographic/physical factors associated with moderate‐to‐severe depression and anxiety.MethodsAnonymised data were acquired from records of consecutive ‘first‐time’ patients seeking TMD care at a tertiary oral medicine clinic. Axis I physical TMD diagnoses were established utilising the diagnostic criteria for TMDs (DC/TMD) protocol and patients with TMD pain were stratified into those with pain‐related (PT) and combined (CT) conditions. Axis II measures administered encompassed the Patient Health Questionnaire‐15 (PHQ‐15), Graded Chronic Pain Scale (GCPS), Patient Health Questionnaire‐9 (PHQ‐9) and General Anxiety Disorder Scale‐7 (GAD‐7). Individuals with PT and CT were further categorised into those without (Pain − Som/Comb − Som) and with somatisation (Pain + Som/Comb + Som). Statistical evaluations were performed with nonparametric and logistic regression analyses (α = 0.05).ResultsThe final sample comprised 473 patients (mean age 36.2 ± 14.8 years; 68.9% women), of which 52.0% had concomitant somatisation. Significant differences in pain duration (Comb + Som > Pain − Som), pain‐related interference/disability (Comb + Som > Comb − Som) and depression/anxiety (Pain + Som, Comb + Som > Pain − Som, Comb − Som) were discerned. Depression/anxiety was moderately correlated with somatisation (rs = 0.64/0.52) but not facial pain characteristics. Multivariate modelling revealed that somatisation was significantly associated with the prospects of moderate‐to‐severe depression (OR 1.35) and anxiety (OR 1.24).ConclusionSomatisation exhibited a strong association with psychological distress when contrasted with facial pain in East Asian TMD patients.
Risk of depression in patients with atopic dermatitis: An updated systematic review and meta‐analysis of children, adolescent and adult groups
Authors: Cao Lihua , Su Jiangwei , Tian Fang , Zhou Yang , Liu Songchun , Lou Fanglu 
Published: September 2024

AimAtopic dermatitis is a popular allergy disease among children, adolescents and adults. The risk of depression in patients with atopic dermatitis can be evaluated using an updated systemic review and meta‐analysis of observational and cross‐sectional studies.MethodsThe log odds ratio (OR) was transformed using the OR and 95% confidence interval (CI) to assess the risk of depression in patients with atopic dermatitis across the children, adolescent and adult groups. After a restricted selection, 39 studies of 234 306 patients with atopic dermatitis and 10 935 459 reference individuals were enrolled. The focused outcome was the OR and 95% CI of depression risk in each included study, assigned according to the age for the children, adolescent and adult groups.ResultsIn adult patients with atopic dermatitis, a significantly higher risk of depression was observed. In addition, the similar significantly higher risk of depression was observed in children and adolescent patients with atopic dermatitis, respectively. However, the significantly high heterogeneity was observed across children, adolescent and adult groups.ConclusionsIn the current meta‐analysis, the patients with atopic dermatitis had a higher risk of depression across the children, adolescent and adult groups, respectively. However, substantial heterogeneity should be considered during the interpretation of our meta‐analysis results.
The 70 years since the discovery of rapid eye movement sleep: history, electroencephalographic features and unsolved issues
Authors: Parrino Liborio , Rausa Francesco , Balella Giulia , Bottignole Dario , Rosenzweig Ivana , Mutti Carlotta 
Published: September 2024

SummaryThis article aims at providing a comprehensive review of the historical discovery and following research on rapid eye movement (REM) sleep, highlighting its manifold nature as a behavioural, electrophysiological and dreaming state. Pioneering works conducted by Aserinsky, Kleitman, Dement and Jouvet established the foundational understanding of REM sleep recurrence, brainstem mechanisms, and the paradoxical coexistence of electroencephalographic activation and muscle atonia. We focus on REM sleep homeostasis, emphasising its role in emotional recovery and the consequences of REM deprivation, such as the REM rebound effect. We also analyse the periodicity of REM sleep, its ultradian rhythm, and the physiological mechanisms underlying its regulation. Additionally, the article discusses the entangled relationship between arousals, sleep, and consciousness, pointing out the distinction between non‐REM and REM sleep‐related arousals, and the similarities between REM sleep and wakefulness.
Evaluation of the efficacy of a live Escherichia coli biotherapeutic product (asymptomatic bacteriuriaE. coli 212)
Authors: Segev Gilad , Chen Hilla , Dear Jonathan D. , Martínez López Beatriz , Pires Jully , Klumpp David J. , Schaeffer Anthony J. , Westropp Jodi L. 
Published: September 2024

AbstractBackgroundRecurrent bacterial cystitis, often referred to as recurrent urinary tract infection (UTI), can be difficult to manage and alternative treatments are needed.Hypothesis/ObjectiveIntravesicular administration of asymptomatic bacteriuria (ASB) E. coli 212 will not be inferior to antimicrobial treatment for the management of recurrent UTI in dogs.AnimalsThirty‐four dogs with >1 UTI in the 12 months before presentation.MethodsAll dogs were deemed normal otherwise based on absence of abnormalities on physical examination, CBC, serum biochemical panel, and abdominal ultrasonography. Dogs were randomized to 1 of 2 treatment groups: Group 1 antimicrobials for 7 days or group 2 intravesicular administration of ASB E. coli 212. Owners were provided a voiding questionnaire regarding their dogs' clinical signs, which was completed daily for 14 days to assess clinical cure. Dogs were examined on days 7 and 14 to assess clinical cure, and urine specimens were submitted for urinalysis and bacterial culture.ResultsClinical cure rates for ASB E. coli 212–treated dogs were not inferior to 7 days of antimicrobial treatment with a 12% margin of difference to determine non‐inferiority. No significant difference was found between the treatment groups on days 7 and 14 in the proportion of dogs achieving ≥50% or ≥75% reduction in their clinical score compared with baseline.Conclusions and Clinical ImportanceThese data suggest that intravesicular administration of ASB E. coli 212 is not inferior to antimicrobials for the treatment of recurrent UTI in dogs. This biotherapeutic agent could help alleviate the need for antimicrobials for some dogs with recurrent UTI, improving antimicrobial stewardship.
An analysis of the burden of liver cirrhosis: Differences between the global, China, the United States and India
Authors: Lu Keqiang , Sui Juanjuan , Yu Wenhui , Chen Yan , Hou Zhiyong , Li Pengyan , Sun Yuli 
Published: September 2024

AbstractBackgroundCirrhosis continues to be the most common cause of chronic liver disease‐related deaths globally, which puts significant strain on global health. This report aims to investigate the patterns of cirrhosis in China, the United States, India and worldwide from 1990 to 2019 through an epidemiological analysis of the disease utilizing data from the Global Burden of Disease Study (GBD) 2019 database.MethodsDownload the GBD database's statistics on liver cirrhosis deaths and Disability‐Adjusted Life Years for the years 1990–2019 worldwide as well as for China, the United States and India. Utilize techniques like age–period–cohort interaction, decomposition analysis, study of health inequities, Joinpoint model and Bayesian Average Annual Percentage Change model to process the data.ResultsThe main age group affected by cirrhosis disease, according to the results, is 50–69 years old. According to the Joinpoint model, there has been a negative worldwide Average Annual Percent Change (AAPC) in the burden of cirrhosis between 1990 and 2019. Only the USA's AAPC is positive out of the three nations that were evaluated (albeit its 95% confidence interval spans 0). These are China, India and the United States. Forecasting models indicate that the prevalence of cirrhosis will keep rising in the absence of government action. According to decomposition analysis, the main factors contributing to the rising burden of cirrhosis are population ageing and size, whereas changes in the disease's epidemiology slow the disease's growth. Research on health disparities indicates that, between 1990 and 2019, there was a downward trend in health disparities between various locations.ConclusionHealth organizations across different areas should take aggressive measures to address the worrisome prevalence of cirrhosis.
The origins of centralized agenda control at Westminster: Consensus or controversy?
Authors: Fleming Thomas G. , Hix Simon , Zubek Radoslaw 
Published: September 2024

AbstractCentralized agenda control is a feature of many parliaments, with important consequences for the conduct and outcomes of legislative politics. Much previous work has thus sought to understand the emergence of centralized agenda‐setting rules. We extend this literature by studying the “Balfour reforms”, which centralized agenda control in the early twentieth century UK House of Commons. Our aim is to probe a conventional claim in the existing literature: that the opposition supported these reforms. This is a counter‐intuitive claim, which rests on relatively little direct evidence. We analyze historical roll‐call data from 1902 to assess how far the opposition supported agenda centralization. We complement this analysis by examining attempted amendments and speech contributions to parliamentary debates. Contrary to the standard view, we find that the primary opposition party consistently resisted these reforms. This evidence of controversy rather than consensus revises our understanding of a key milestone in the development of the Westminster parliament, and contributes to the wider literature on the choice of agenda‐setting procedures.
Comparative efficacy of non‐pharmacological interventions for anxiety in adult intensive care unit patients: A systematic review and network meta‐analysis
Authors: Ma Yanfei , Yang Xiuru , Wang Chunyan , Li Yeping , Zhang Yaqing , Wang Lihui , Hu Rong , Li Xixi 
Published: September 2024

AbstractBackgroundThe primary goal of the intensive care unit is to the anxiety of conscious patients is often ignored in the care unit.AimThe purpose of this study was to assess the efficacy of various non‐pharmacological therapies for anxiety disorders in adult patients in the intensive care unit, in order to enhance humanistic care in the intensive care unit and to promote the patients' physical and mental recovery together.Study DesignWe conducted a systematic and comprehensive search of the literature in five databases (including the Cochrane Library, PubMed, EBSCO, Web of Science, and Embase) covering nearly a decade for randomized controlled trials of non‐pharmacological therapies to reduce anxiety in adult intensive care unit patients. Two researchers independently assessed the quality of the literature, collected and condensed the data, and used STATA software to perform a network meta‐analysis. The ranking probabilities for each intervention were calculated using the Surface under the Cumulative Ranking (SUCRA) method. The study protocol was registered with PROSPERO.ResultsThis study ultimately included 26 randomized controlled trials involving 2791 adult ICU patients. Non‐pharmacological interventions for anxiety in adult ICU patients included music therapy, aromatherapy, ICU diary, virtual reality, massage therapy, monitoring room diary, and health education. when compared to the control group (usual care), aromatherapy + music therapy [MD = −2.65, 95% CI (−4.76, −0.54)] (P = 0.0137) and music therapy [MD = −1.77, 95% CI (−3.40, −0.13)] (P = 0.0338) were superior in reducing anxiety in adult ICU patients. The results of the network meta‐analysis showed that aromatherapy combined with music therapy significantly alleviated anxiety in adult ICU patients (SUCRA: 99.8%).ConclusionsMusic therapy combined with aromatherapy has demonstrated superior effectiveness compared to other non‐pharmacological interventions for reducing anxiety in awake adults in the ICU. However, the underlying mechanisms of this combined therapy require further exploration.Relevance to Clinical PracticeFuture research on the use of music therapy combined with aromatherapy in the care unit may help reduce anxiety in patients while fostering their physical and mental healing; however, individual variances and unique clinical circumstances must be considered.