bluuebunny/crossref_metadata_2025_split huggingface dataset:
Race- associated molecular differences in uterine serous carcinoma
Authors: Lara Olivia D. , Karpel Hannah , Friedman Steven , Hacker Kari E. , Pothuri Bhavana 
Published: October 2024

PurposeEndometrial cancer (EMCA) is the most common gynecologic malignancy, and new diagnoses are increasing in the United States. Black patients are more likely to present with advanced stage, be diagnosed with high-risk uterine serous carcinoma (USC) and die of their cancer.MethodsPatients with endometrial adenocarcinoma who received tumor FoundationOne CDx testing at our institution between January 2017 and August 2022 were identified. Genomic alterations, demographic and clinical characteristics were collected. Descriptive statistics and Fisher’s exact test were used to analyze data.ResultsA total of 289 patients (29.4% Black and 52.6% White) with advanced or recurrent endometrial adenocarcinoma underwent FoundationOne CDx testing. USC comprised 26.3% (76 of 289) of tested tumors. Of USC tumors, 33 of 76 (44%) were of Black race. USC occurred more frequently in Black patients (33 of 85 [38.8%] Black patients compared to 30 of 152 [19.7%] White patients, p&lt;0.05). Among USC, CCNE1 amplification occurred more frequently in Black patients than in White patients (12 of 33 [36.36%] vs 2 of 30 [6.67%], p&lt;0.05) while PI3K/AKT/mTOR pathway mutations occurred less frequently (16 of 33 [48.5%] vs 26 of 33 [86.7%], p=0.17). Among patients with CCNE1 amplification 73.3% (11 of 15) progressed on or within 12 months of first-line platinum-based therapy. CCNE1 amplification had significantly shorter median overall survival (97.3 months vs 44.3; HR (95%CI): 7.1 (10.03, 59.4) p&lt; 0.05).ConclusionsBlack patients constituted 44% of patients with USC in our study and had an increased frequency of CCNE1 amplification. Patients whose tumors harbored CCNE1 amplification had shorter overall survival. Identifying actionable mutations in this high unmet need population is crucial to improving outcomes among Black patients with uterine malignancy. Development of new targeted-therapies will need to keep these alterations at the forefront as trials are being designed.
Analysis of electrode performance on amplitude integrated electroencephalography in neonates: evaluation of a new electrode aCUP-E vs. liquid gel electrodes
Authors: Fabregat-Sanjuan Albert , Rodríguez-Ballabriga Ángel , Rigo-Vidal Agnès , Pàmies-Vilà Rosa , Larrosa-Capaces Susana , Rius-Costa Vanesa , Pascual-Rubio Vicenç 
Published: October 2024

BackgroundNeonatologists and clinical neurophysiologists face challenges with the current electrodes used for long-duration amplitude-integrated electroencephalography (aEEG) in neonatal intensive care units (NICU), limiting the capacity to diagnose brain damage.ObjectivesThe objectives of this study were to develop methods for comparing the performance of different electrodes to be used in aEEG. The comparison was done between a newly designed neonate-specific electrode, aCUP-E, with commercial liquid gel electrodes used in amplitude-integrated electroencephalography (aEEG). The comparison included impedance stability, electrode survival, recording quality, usability, and satisfaction of NICU staff.MethodsaEEG recordings with bipolar montage was used, with one hemisphere fitted with commercial electrodes and the other with aCUP-E electrodes, alternated among subjects. Continuous impedance and raw EEG data were collected over a minimum of 24 h, and signal processing was performed using Python and MATLAB.Main resultsaCUP-E electrodes demonstrated superior performance, including: Increased impedance stability and electrode survival, enhanced recording quality with fewer artifacts, high correlation in signal capture between electrodes during optimal brain activity segments, higher signal-to-noise ratio (SNR) across varying impedance levels, greater staff satisfaction and ease of use. Moreover, Kaplan-Meier curves indicated a higher survival rate for aCUP-E electrodes over 24 h compared to commercial electrodes. Impedance variability analysis showed statistically significant stability improvements for aCUP-E.ConclusionaCUP-E electrodes outperform commercial liquid gel electrodes in impedance stability, electrode survival, and recording quality. These results suggest that aCUP-E electrodes could significantly enhance aEEG utilization in diagnosing and treating neonatal brain conditions in NICUs. Future improvements to the aCUP-E electrode may further reduce artifacts and increase electrode longevity, potentially leading to a significant improvement in neonatal brain monitoring by means of aEEG.
Lats-IN-1 protects cardiac function and promotes regeneration after myocardial infarction by targeting the hippo pathway
Authors: Shen Hua , Wang Qing , Liu Bohan , Wang Yihui , Zhou Dandan , Zhang Lin , Zhuang Jinqiang 
Published: October 2024

IntroductionMyocardial infarction (MI), a leading cause of heart failure, is characterized by the loss of cardiomyocytes, which severely limits the heart’s regenerative capacity. The Hippo pathway, which regulates cell proliferation and apoptosis, presents a therapeutic target for cardiac regeneration. This study explores the efficacy of Lats-IN-1, a LATS1/2 kinase inhibitor targeting the Hippo pathway, as a novel treatment for MI.MethodsUsing male C57BL/6 mice subjected to surgically induced MI, we administered Lats-IN-1 and evaluated the effects on cardiac function, infarct size, cardiomyocyte proliferation, and apoptosis through various assays and echocardiographic assessments.ResultsOur results demonstrate that Lats-IN-1 significantly improves cardiac function, as evidenced by enhanced ejection fraction and reduced ventricular dimensions. Additionally, Lats-IN-1 decreased infarct size and apoptosis rates while promoting cardiomyocyte proliferation. These findings suggest that Lats-IN-1 promotes cardiac repair and regeneration.DiscussionBy modulating the Hippo pathway and reducing apoptosis markers, Lats-IN-1 represents a promising therapeutic strategy for improving outcomes in heart diseases characterized by cardiomyocyte loss. This study highlights the critical role of the Hippo pathway in facilitating cardiac regeneration.
The relationship between community workers’ occupational stress, social support and psychological health: an empirical study in Liaoning Province, China
Authors: Sen Qin , Lei Zhang 
Published: October 2024

BackgroundWith increasing urbanization in China, the community has assumed the important task of social governance and service provision, which has resulted in an increase in community workers’ occupational stress. To date, researchers have studied ways to improve community workers’ working ability, but have paid less attention to their health, especially their psychological health. This study examined the relationship between occupational stress, social support and community workers’ psychological health.MethodsA total of 545 community workers from 14 cities in Liaoning Province completed a questionnaire including the Occupational Adaptability Scale for Employees (OASE), the Social Support Rating Scale (SSRS) and the SCL-90-R scale (a measure of psychological health). Correlational and regression analyses were conducted.ResultsCommunity workers’ occupational stress mainly derives from their workload, career development opportunities and performance appraisals. Participant’s psychological health scores were significantly negatively correlated with occupational stress and significantly positively correlated with social support. Social support plays a moderating effect in the relationship between community workers’ occupational stress and their psychological health.ConclusionIt is necessary to establish an effective community support system, reduce the burden on the community, optimize existing work processes and performance appraisal system, create a positive working environment and organizational culture, and promote employee’s psychological health.
Analyzing the influence of physical exercise interventions on social skills in children with autism spectrum disorder: insights from meta-analysis
Authors: Koh Sung Hee 
Published: October 2024

IntroductionChildren diagnosed with autism spectrum disorder (ASD) commonly encounter difficulties in social interactions and communication, significantly affecting their overall wellbeing. One proposed strategy to address these challenges is through physical exercise interventions. This study aims to conduct a meta-analysis to assess the impact of physical exercise interventions on the social skills of children with ASD.MethodsTo perform this meta-analysis, we followed the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) Statement and the practical guide for transparent reporting of systematic reviews. Eligible studies included randomized controlled trials or quasi-experimental studies investigating the effects of physical exercise interventions on social skills among children with ASD. We used the standardized mean difference (SMD) to measure effect size.ResultsSixteen studies were included in the meta-analysis. The results indicated a significant improvement in social skills among children with ASD following physical exercise interventions (SMD = −0.54, 95% CI = [−0.63; −0.44]). The moderator analysis underscored the crucial role of age in explaining the intervention outcomes for enhancing social skills, with interventions lasting more than 12 weeks recommended for better social skills improvement.DiscussionThe findings of this meta-analysis provide robust evidence supporting the efficacy of physical exercise interventions in enhancing the social skills of children with ASD. The moderator analysis underscores the importance of considering both the mean age and duration of interventions when implementing such programs. These results underscore the significance of physical exercise as a viable option for improving social skills in this population.
Focus group on conflict management in the classroom in Secondary Education in Costa Rica: mixed methods approach
Authors: Bonilla R. Pedro , Armadans Immaculada , Anguera M. Teresa 
Published: October 2024

IntroductionThe educational system in Costa Rica, as regulated by Law #7727, which governs Alternative Conflict Resolution and Promotion of Social Peace must consider the interplay of various factors influencing classroom conflicts and the management strategies employed by teachers. Consequently, it becomes imperative to identify the most effective conflict resolution practices applicable within this context. To achieve this, a thorough procedure based on mixed methods was employed to analyze and interpret both classroom conflict behaviors and teachers’ strategic responses.MethodThis study employed an indirect observational methodology, from a mixed methods approach. Data was collected through a focus group comprised of teachers. Following the connect framework, the procedure was conducted in three phases: QUAL-QUAN-QUAL. Two analytical techniques were implemented. A lag sequential analysis was used to explore potential behavioral patterns. The results of this analysis informed a polar coordinate analysis, which generated a visual representation of the relationships between codes.Results and discussionA focus group addressed four questions, yielding satisfactory data quality control results (kappa values: 0.80, 0.77, 0.76, 0.82). In polar coordinate analysis, the 37 observational instrument categories were designated as focal behaviors. Each of the 37 analyses treated all categories as conditioned behaviors. The analysis identified 342 activation/inhibition relationships between focal and conditioned behaviors. Of these, 195 were statistically highly significant, distributed across quadrants: Quadrant I (106), Quadrant II (36), Quadrant III (16), Quadrant IV (36). Significant gaps in understanding of conflict were identified, along with disparities in the resources and competencies necessary for successful conflict resolution among the observed educators. Specifically, teachers frequently employed techniques informed by intuition rather than deliberate strategy learned in their training. Consequently, the study advocates for enhancing teachers’ cognitive and emotional competencies to optimize conflict management within the classroom and bolster their adaptive coping mechanisms.
Cardiac Rehabilitation practitioners’ views on patients’ psychological needs: a qualitative study
Authors: Wray Laura , Capobianco Lora , Wells Adrian 
Published: October 2024

BackgroundPsychological difficulties are prevalent in patients undergoing Cardiac Rehabilitation (CR). Recent guidelines recommend that practitioners inquire and address patients’ psychological concerns during CR. Therefore, Study One aimed to explore practitioners’ understanding of patients’ psychological needs, their confidence in supporting those needs, and their views on whether current CR meets patients’ needs. Study Two aimed to validate Study Ones’ findings among a wider sample of CR practitioners.MethodsThis study consisted of two interrelated qualitative interviews. Study One utilised qualitative interview data from the PATHWAY trial (REC Reference:15/NW/0163), while Study Two utilised new interview data collected as part of the PATHWAY Beacons study (REC Reference: 22/HRA/2220). In Study One semi-structured interviews with six CR practitioners were analysed using thematic analysis. In Study Two, 11 CR practitioners across England were interviewed using member-checking principles. Transcripts were coded systematically using the codes developed in Study One and, through constant comparative analysis.ResultsFour main themes were identified: staff’s awareness of mental health problems, CR patients’ needs, staff’s self-efficacy to support patients’ psychological needs, and current psychological provision in CR. The main themes and 11 subthemes were transferable to a wider range of CR practitioners, thereby indicating the trustworthiness of the findings.ConclusionPractitioners described that patients experience a range of psychological concerns, including adjustment difficulties, anxiety, and cardiac and noncardiac worries. Most practitioners normalise patient concerns and offer relaxation techniques. However, practitioners have noted that patients often have complex psychological needs, but practitioners’ confidence in discussing and supporting psychological concerns varies. Practitioners expressed the need for training to support patients’ psychological needs.
Association of internet use and health service utilization with self-rated health in middle-aged and older adults: findings from a nationally representative longitudinal survey
Authors: Ma Ximin , Hu Qi , He Jiahui , Wang Wenlong , Chen Kexin , Qiao Hui 
Published: October 2024

ObjectiveThis study aims to explore the relationship between internet use and self-rated health among middle-aged and older adults and further investigates the mediating role of health service utilization between internet use and self-rated health, providing a reference for more effectively utilizing the internet to improve the health status of middle-aged and older adults.MethodWe analyzed data from the 2018 and 2020 waves of the China Health and Retirement Longitudinal Study (CHARLS), this includes 10,011 in 2018 and 7,080 in 2020 over the age of 45. To explore the relationship between internet use and self-rated health, we employed propensity score matching (PSM) and instrumental variable regression analysis, accounting for a wide range of potential covariates. Additionally, the Sobel test was used to examine the mediating effect of health service utilization on this relationship.ResultsAccording to the fully adjusted propensity score matching and instrumental variable regression model, internet use significantly enhanced self-rated health among middle-aged and older adults (β = 0.348, P &lt; 0.01; β = 0.293, P &lt; 0.1). However, subgroup analyses revealed that this positive effect was not significant among middle-aged and older adults who were divorced (β = 0.190, P &gt; 0.05), lived in special zone (β = −1.379, P &gt; 0.05), and lacked medical insurance (β = 0.314, P &gt; 0.05). Furthermore, mediation analysis revealed that inpatient services (β = 0.0215, P &lt; 0.01) acted as a mediator in the relationship between internet use and self-rated health.ConclusionInternet use positively correlates with self-rated health among middle-aged and older adults. Additionally, the utilization of health services can significantly influence this relationship. These findings underscore the importance of developing targeted government strategies to promote internet access and create a supportive online environment, thereby enhancing the health outcomes of this demographic group.
A 10-year trend in cannabis potency (2013–2022) in different geographical regions of the United States of America
Authors: ElSohly Mahmoud A. , Majumdar Chandrani G. , Chandra Suman , Radwan Mohammed M. 
Published: October 2024

BackgroundThe prevalence of cannabis as the most commonly used illicit substance in the United States and around the globe is well-documented. Studies have highlighted a noticeable uptrend in the potency of cannabis in the United states. This report examines the concentration of cannabinoids in illicit cannabis samples seized by the United States Drug Enforcement Administration (DEA) over the last 10 years (2013–2022).MethodsSamples received during the course of study (2013–2022) were categorized based on the geographical region where collected, as Western Region, Midwest Region, Northeast Region, South East Region, Southern Region as well as Alaska and Hawaii. These samples were processed for analysis using a validated gas chromatography with flame ionization detector method.ResultsThe data showed that the cannabinoids profile of all high Δ9-THC cannabis samples, regardless of the state or region from which the samples are seized or the state from which the sample is produced under a state medical marijuana program, is basically the same with the major cannabinoid being Δ9-THC (&gt;10% for most samples) and all other cannabinoids with less than 0.5%, with the exception of CBG (&lt;1%) and CBN (&lt;1%).ConclusionOverall, it appears the cannabinoids profile is controlled by the genetics of the plant and is not affected much by the geographical location in which the plants are cultivated.
Daily diurnal temperature range associated with emergency ambulance calls: a nine-year time-series study
Authors: Guo Chaohui , Cai Keke , Chen Gao , Wang Jin , Zeng Jie , Huang Xiaoqing , Deng Mengling 
Published: October 2024

BackgroundDiurnal temperature range (DTR) is associated with the increased risk of morbidity and mortality. However, the relationship between DTR and emergency ambulance calls (EACs), which more accurately and immediately reflect the health impacts of temperature changes, remains underexplored in China.MethodsWe collected daily data on EACs and meteorological factors from 2009 to 2017 in Guangzhou, China. DTR, representing the temperature range within a day, was calculated by subtracting the minimum temperature from the maximum temperature for each day. Generalized additive models were used to estimate the association between DTR and EACs for all-cause, cardiovascular diseases, and respiratory diseases. Additionally, subgroup and sensitivity analyses were conducted in our study.ResultsWe found significant associations between daily DTR and EACs. The excess risks (ERs) were 0.47% (95% CI: 0.14, 0.81%) for all-cause EACs, 0.94% (95% CI: 0.46, 1.43%) for cardiovascular-related EACs, and 1.31% (95% CI: 0.76, 1.86%) for respiratory -related EACs at lag01, respectively. Subgroup analyses indicated that these associations were notably stronger among the older, males, and during the warm season. Specifically, there was an increase of 1.16% (95% CI: 0.59, 1.74%) in cardiovascular-related EACs among the older adult, compared to 0.45% (95% CI: −0.21, 1.12%) among those younger than 65 years. Among males, the increase was 1.39% (95% CI: 0.79, 1.99%), compared to 0.13% (95% CI: −0.53, 0.79%) among females. During the warm season, the increase was 1.53% (95% CI: 0.74, 2.34%), compared to 0.75% (95% CI: 0.14, 1.37%) during the cold season.ConclusionDTR might increase the risk of daily all-cause, cardiovascular-related, and respiratory-related EACs in Guangzhou, China. The associations were particularly strong among older adults, males, and during the warm season. Implementing public health policies is essential to mitigate the adverse health effects of DTR.
Long-Term Efficacy of Posterior Neurectomy in Anterior Cutaneous Nerve Entrapment Syndrome
Authors: ten Have Tom , Jacobs Monica L. Y. E. , Scheltinga Marc R. M. , Zwaans Willem A. R. , Roumen Rudi M. H. 
Published: October 2024

ObjectiveTo analyze long-term treatment outcomes of a posterior neurectomy in a large cohort of patients with anterior cutaneous nerve entrapment syndrome (ACNES).Summary Background DataThe current step-up treatment approach for ACNES involves abdominal wall tender point injections, pulsed radiofrequency, and neurectomy. If an anterior neurectomy fails or pain reoccurs, a posterior neurectomy is considered as a final surgical option. Data on posterior neurectomy treatment outcomes are scarce.MethodsACNES patients who underwent a unilateral posterior neurectomy between 2012 and 2022 in a single institution completed a questionnaire regarding their current pain status. Primary outcomes were short- and long-term treatment success, defined as ≥50% pain relief. Patients were stratified whether the operative indication was recurrent pain (&gt;3 months) after an initially successful anterior neurectomy or ongoing pain after an anterior neurectomy.ResultsData from 260 of 379 patients (77% female, mean age 42 years) were analyzed (68.6% response rate). Sensitivity analysis found that short-term outcomes were similar between responders and non-responders. The recurrent pain group demonstrated significantly better treatment outcomes compared to the ongoing pain group, both in the short-term (7 weeks; treatment success 79.2% vs. 53.2%, p &lt; 0.001) and long-term (58 months; treatment success 61.1% vs. 42.0%, p = 0.001). Sixteen (minor) complications (6.2%) were reported, resulting in three surgical re-interventions (1.2%).ConclusionA posterior neurectomy is long-term beneficial in approximately half of patients although treatment success is better for recurrent pain than ongoing pain. These findings aid in optimizing preoperative patient counseling.