bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of computed tomography imaging during long-term follow-up of nine feline tuberculosis cases
Authors: Major Alison , O’Halloran Conor , Holmes Andrea , Lalor Stephanie , Littler Rebecca , Spence Susanna , Schwarz Tobias , Gunn-Moore Danièlle 
Published: March 2017

Case series summary Feline tuberculosis is an increasingly recognised potential zoonosis of cats. Treatment is challenging and prognosis can vary greatly between cases. Pulmonary infection requires extended courses of antibiotics, but methodologies for sensitively monitoring response to treatment are currently lacking. In this case series, we retrospectively examined the serial computed tomography (CT) findings in nine cats that had been diagnosed with tuberculosis. Changes in pathology (where applicable to tuberculosis) were correlated with the clinical presentation of each of the cats, the treatment protocol, and previous and contemporary diagnostic investigations. This study found that changes in CT findings during the medium- to long-term management of feline tuberculosis were highly variable between cats. The majority of cats had reduced pathology at re-examination during anti-tuberculous therapy, but pathology only resolved in a minority of cases. In some cases recurrence of pathology detected by CT imaging preceded clinical deterioration, allowing for rapid therapeutic intervention. Relevance and novel information When considered in combination with clinical findings, CT studies can aid in decision making regarding tapering of antibiotic protocols, or reintroduction of therapy in cases of recurrence or reinfection. This series also highlights that, in some cases, persistent abnormalities can be detected by CT, so complete resolution of CT pathology should not always be a goal in the management of feline tuberculosis.
Using Mobile Phone Technology to Support Young Liver Transplant Recipients Moving to Adult Services
Authors: Coad Jane , Toft Alex , Claridge Lee , Ferguson James , Hind Jonathon , Jones Rebecca , McClean Patricia , McKiernan Patrick , Samyn Marianne , Taylor Rachel 
Published: March 2017

Background: The process and preparation of moving from child to adult services (transition) is a challenging period of time for young people and represents significant changes in care and support systems. The proliferation of mobile phone applications for health purposes suggests that it is an area for further investigation. Objective: The review explores the potential to use mobile phone technology to help support young liver transplant recipients moving to adult services. It represents the first review conducted in this specialism and considers a new model of support for young liver patients. Methods: A systematic rapid review of the published peer-reviewed literature. Results: Two searches were conducted: Search 1: the use of technology to support transition to adult services (6 studies) and Search 2: how best to support liver transplant recipients during transition (6 studies). Discussion: Research shows that to achieve positive transition young people need information about their condition and transition. The process needs to be guided by transition readiness, rather than the young persons’ age. Although parents and support networks should be in place and are valued, transition should build upon self-management and independence. Results suggest that there appears to be scope to use mobile phone technology to support transition. This is the first time a review has explored the types of issues or concerns facing liver transplant patients and how these can be addressed through mobile phone technology.
The Relationship Between Eyewitness Confidence and Identification Accuracy: A New Synthesis
Authors: Wixted John T. , Wells Gary L. 
Published: March 2017

Summary The U.S. legal system increasingly accepts the idea that the confidence expressed by an eyewitness who identified a suspect from a lineup provides little information as to the accuracy of that identification. There was a time when this pessimistic assessment was entirely reasonable because of the questionable eyewitness-identification procedures that police commonly employed. However, after more than 30 years of eyewitness-identification research, our understanding of how to properly conduct a lineup has evolved considerably, and the time seems ripe to ask how eyewitness confidence informs accuracy under more pristine testing conditions (e.g., initial, uncontaminated memory tests using fair lineups, with no lineup administrator influence, and with an immediate confidence statement). Under those conditions, mock-crime studies and police department field studies have consistently shown that, for adults, (a) confidence and accuracy are strongly related and (b) high-confidence suspect identifications are remarkably accurate. However, when certain non-pristine testing conditions prevail (e.g., when unfair lineups are used), the accuracy of even a high-confidence suspect ID is seriously compromised. Unfortunately, some jurisdictions have not yet made reforms that would create pristine testing conditions and, hence, our conclusions about the reliability of high-confidence identifications cannot yet be applied to those jurisdictions. However, understanding the information value of eyewitness confidence under pristine testing conditions can help the criminal justice system to simultaneously achieve both of its main objectives: to exonerate the innocent (by better appreciating that initial, low-confidence suspect identifications are error prone) and to convict the guilty (by better appreciating that initial, high-confidence suspect identifications are surprisingly accurate under proper testing conditions).
Tentorial meningioma supplied by a marginal tentorial artery arising from the superior cerebellar artery: Anatomic and technical considerations
Authors: Lenck Stéphanie , Watanabe Kentaro , Saint-Maurice Jean-Pierre , Labidi Moujahed , Labeyrie Marc-Antoine , Froelich Sébastien , Houdart Emmanuel 
Published: March 2017

Background and importance The marginal tentorial artery runs over the free edge of the tentorium. Different origins have been described, always involving branches of the carotid artery. We report the superior cerebellar artery as an unknown origin of this artery. We developed our strategy in a case of a tentorial meningioma mainly supplied by this artery. Clinical presentation A 53-year-old man was admitted in our institution for the surgical treatment of a large tentorial and petroclival meningioma. A 2D conventional angiogram was insufficient to detect the tumoral blush. A 3D digital subtraction angiogram (DSA) of the vertebral artery highlighted a blush arising from a marginal tentorial artery fed by the superior cerebellar artery. Selective embolization of this branch led to significant devascularization of the tumor. A total tumor resection was performed 24 h after embolization without complication. The dural medial tentorial artery of the superior cerebellar artery is relatively unknown and courses at the inferior surface of the tentorium. We report the first case in which the marginal tentorial artery arises from this artery. Major bleeding may result from its section or its avulsion from the superior cerebellar artery during surgery; its preoperative diagnosis is thus essential. In this case, a 3D-DSA with dual volume visualization was more sensitive than a 2D conventional angiogram to detect such an anatomic variant. Conclusion The marginal tentorial artery may originate from the superior cerebellar artery. The recognition of this anatomic variant may be essential to avoid hemorrhagic complications during surgery of hypervascular tumors of the tentorium.
Impact of renal arterial morphology on fluoroscopy time in chimney endovascular aneurysm repair
Authors: Sugimoto Masayuki , Torsello Giovanni , Donas Konstantinos P 
Published: March 2017

Objectives To evaluate the impact of renal artery morphology on fluoroscopy time in chimney endovascular aneurysm repair. Methods Morphology of renal artery was retrospectively quantified in the preoperative CT angiography. Renal artery angulation, ostial diameter, severity of ostial stenosis, main renal artery length, and tortuosity were analyzed with a 3D workstation. The main measure outcome was fluoroscopic time as an indicator of complexity. Uni- and multivariate logistic regression analyses were performed to determine predictors of longer fluoroscopy. Secondary endpoints were amount of contrast medium, patency of renal artery, and type Ia endoleak. Results The enrolled 38 patients (mean age 75.0 years; 34 males) were stratified at the median of fluoroscopic time of 35.2 min (interquartile range, 21.5) and classified in group A ( n = 19) and group B ( n = 19) having a fluoroscopic time of 24.5 (interquartile range, 5.9) and 46.4 (interquartile range, 16.0) min, respectively. The severity of ostial stenosis (OsSte) was significantly different between group A and B of 26.3 ± 13.4% and 41.6 ± 18.0%, respectively; P < .01. ROC curve analysis revealed that 35.5% was an optimal cut-off for OsSte. The difference of renal angulation (RAng) (−22.5° and −2.0°; interquartile ranges 49 and 35; P = .13), and main renal artery length (33.4 ± 11.8 mm and 33.7 ± 14.3 mm; P = .94) were not significantly different. In multivariate analysis after dichotomizing OsSte and RAng, OsSte > 35.5% was identified as the only significant predictor for the longer fluoroscopy (HR: 4.33; 95% CI: 1.02–18.4, P = .04). As for the secondary endpoints, no significant differences were observed between the groups. No correlation between longer fluoroscopy and renal patency or type Ia endoleak was observed. Conclusion Severity of ostial stenosis seems to be a significant predictor for longer fluoroscopic time.
Central poststroke pain: A systematic review
Authors: Singer Jonathan , Conigliaro Alyssa , Spina Elizabeth , Law Susan W , Levine Steven R 
Published: March 2017

Background Physical, psychological, and/or social impairment can result after a stroke and can be exacerbated by pain. One type of pain after stroke, central poststroke pain, is believed to be due to primary central nervous system mechanisms. Estimated prevalence of central poststroke pain ranges widely from 8% to 55% of stroke patients, suggesting a difficulty in reliably, accurately, and consistently identifying central poststroke pain. This may be due to the absence of a generally accepted definition. Aim We aimed to clarify the role of thalamic strokes and damage to the spinothalamic pathway in central poststroke pain patients. Also, we aimed to gain a current understanding of anatomic substrates, brain imaging, and treatment of central poststroke pain. Summary of review Two independent reviewers identified 10,144 publications. Based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, we extracted data from 23 papers and categorized the articles’ aims into four sections: somatosensory deficits, pathway stimulation, clinical trials, and brain imaging. Conclusions Our systematic review suggests that damage to the spinothalamic pathway is associated with central poststroke pain and this link could provide insights into mechanisms and treatment. Moreover, historical connection of strokes in the thalamic region of the brain and central poststroke pain should be reevaluated as many studies noted that strokes in other regions of the brain have high occurrence of central poststroke pain as well.
Percentile ranks and benchmark estimates of change for the Health Education Impact Questionnaire: Normative data from an Australian sample
Authors: Elsworth Gerald R , Osborne Richard H 
Published: March 2017

Objective: Participant self-report data play an essential role in the evaluation of health education activities, programmes and policies. When questionnaire items do not have a clear mapping to a performance-based continuum, percentile norms are useful for communicating individual test results to users. Similarly, when assessing programme impact, the comparison of effect sizes for group differences or baseline to follow-up change with effect sizes observed in relevant normative data provides more directly useful information compared with statistical tests of mean differences and the evaluation of effect sizes for substantive significance using universal rule-of-thumb such as those for Cohen’s ‘d’. This article aims to assist managers, programme staff and clinicians of healthcare organisations who use the Health Education Impact Questionnaire interpret their results using percentile norms for individual baseline and follow-up scores together with group effect sizes for change across the duration of typical chronic disease self-management and support programme. Methods: Percentile norms for individual Health Education Impact Questionnaire scale scores and effect sizes for group change were calculated using freely available software for each of the eight Health Education Impact Questionnaire scales. Data used were archived responses of 2157 participants of chronic disease self-management programmes conducted by a wide range of organisations in Australia between July 2007 and March 2013. Results: Tables of percentile norms and three possible effect size benchmarks for baseline to follow-up change are provided together with two worked examples to assist interpretation. Conclusion: While the norms and benchmarks presented will be particularly relevant for Australian organisations and others using the English-language version of the Health Education Impact Questionnaire, they will also be useful for translated versions as a guide to the sensitivity of the scales and the extent of the changes that might be anticipated from attendance at a typical chronic disease self-management or health education programme.
Clinical outcomes for the obese hospital inpatient: An observational study
Authors: Fusco KL , Robertson HC , Galindo H , Hakendorf PH , Thompson CH 
Published: March 2017

Objectives: The prevalence of obesity presents a burden for Australian health care. The aim of this study was to determine whether severely obese hospital inpatients have worse outcomes. Methods: This is an observational cohort study, using data from all adult patients admitted to hospital for all elective and emergency admissions of patients aged over 18 years to two large Australian urban hospitals. We measured their length of stay, intensive care unit admission rate, intensive care unit length of stay, mortality and readmission rates within 28 days of discharge and compared these outcomes in the severely obese and non-severely obese subjects using t-test or chi-square test as appropriate. Results: Between February 2008 and February 2012, 120,872 were admitted to hospital 193,800 times; 2701 patients were identified as severely obese (2.23%) and 118,171 patients were non-severely obese. If admitted as an emergency, severely obese patients have worse outcomes and consume more resources than other patients. These outcomes are still worse, but less so, if the obese patient is admitted as an elective patient suggesting that anticipation of any obesity-specific problems can have a beneficial effect. Conclusion: Upon admission or discharge of severely obese hospital inpatients, health care plans should be even more carefully laid than usual to reduce the risk of readmission.
Are Markets with Loss-Averse Consumers More Sensitive to Losses?
Authors: Hu Zhenyu , Nasiry Javad 
Published: March 2017

Behavioral pricing and revenue management aim to incorporate realistic consumer behavior into firms’ pricing and inventory models. The key input to these models is market demand, which is often assumed to inherit the characteristics of consumer behavior—as when, for example, one assumes that a market consisting of loss-averse consumers is more responsive to losses than to gains. Yet market demand and consumer behavior need not be related, and so, we argue, that approach to modeling market demand is misguided. This paper proposes an approach that accounts for the heterogeneity in consumer valuation: we aggregate the demand of individual loss-averse consumers to obtain market demand and show that market demand may be more responsive to gains or losses, or it may be equally responsive. Our results have profound implications not only for how best to characterize the market demand of behaviorally biased consumers but also for determining the firm’s optimal pricing policy.This paper was accepted by Serguei Netessine, operations management.
Optimal Network Design with End-to-End Service Requirements
Authors: Balakrishnan Anantaram , Li Gang , Mirchandani Prakash 
Published: March 2017

Long-term planning for transportation, telecommunications, and other service operations entails designing networks that are both cost effective and responsive. Because infrastructure networks are expensive and the network’s design determines its service capabilities, planners must address complex trade-offs between minimizing the total cost of the network while meeting end-to-end service requirements such as limits on transit time, latency, and transshipments. To address this problem, we study a minimum cost multicommodity network design model to select arcs and route the required flows along these arcs so that each origin-to-destination route satisfies limits on various service metrics. To effectively solve this service network design problem, we focus on a polyhedral approach to strengthen its arc flow formulation. We develop several classes of strong cuts, with appropriate separation procedures, and propose an optimization-based heuristic method. We characterize the dimension of the problem’s feasible region and show that two classes of inequalities are facet-defining under appropriate conditions. Our computational results demonstrate that our Composite method, incorporating the valid inequalities and heuristic algorithm, significantly reduces computational time and generates near-optimal solutions. The model and methods developed in this paper provide a valuable planning tool for service providers in transportation, telecommunication, and other sectors. The online appendix is available at https://doi.org/10.1287/opre.2016.1579 .
Expression analysis of platelet‐derived growth factor receptor alpha and its ligands in the developing mouse lung
Authors: Gouveia Leonor , Betsholtz Christer , Andrae Johanna 
Published: March 2017

AbstractActivation of the platelet‐derived growth factor receptor‐α (PDGFRα) signaling pathway is critically important during lung alveogenesis, the process in lung development during which alveoli are formed from the terminal alveolar sacs. Several studies have aimed to characterize the expression patterns of PDGFRα and its two ligands (PDGF‐A and ‐C) in the lung, but published analyses have been limited to embryonic and/or perinatal time points, and no attempts have been made to characterize both receptor and ligand expression simultaneously. In this study, we present a detailed map of the expression patterns of PDGFRα, PDGF‐A and PDGF‐C during the entire period of lung development, that is, from early embryogenesis until adulthood. Three different reporter mice were analyzed (Pdgfaex4‐COIN‐INV‐lacZ, Pdgfctm1Nagy, and Pdgfratm11(EGFP)Sor), in which either lacZ or H2B‐GFP were expressed under the respective promoter in gene‐targeted alleles. A spatiotemporal dynamic expression was identified for both ligands and receptor. PDGF‐A and PDGF‐C were located to distinct populations of epithelial and smooth muscle cells, whereas PDGFRα expression was located to different mesenchymal cell populations. The detailed characterization of gene expression provides a comprehensive map of PDGFRα signaling in lung cells, opening up for a better understanding of the role of PDGF signaling during lung development.
Physiological and biochemical changes associated with acute experimental dehydration in the desert adapted mouse, Peromyscus eremicus
Authors: Kordonowy Lauren , Lombardo Kaelina D. , Green Hannah L. , Dawson Molly D. , Bolton Evice A. , LaCourse Sarah , MacManes Matthew D. 
Published: March 2017

AbstractCharacterizing traits critical for adaptation to a given environment is an important first step in understanding how phenotypes evolve. How animals adapt to the extreme heat and aridity commonplace to deserts is an exceptionally interesting example of these processes, and has been the focus of study for decades. In contrast to those studies, where experiments are conducted on either wild animals or captive animals held in non‐desert conditions, the study described here leverages a unique environmental chamber that replicates desert conditions for captive Peromyscus eremicus (cactus mouse). Here, we establish baseline values for daily water intake and for serum electrolytes, as well as the response of these variables to acute experimental dehydration. In brief, P. eremicus daily water intake is very low. Its serum electrolytes are distinct from many previously studied animals, and its response to acute dehydration is profound, though not suggestive of renal impairment, which is atypical of mammals.
Addition of Whey Protein in Bread-Making: Textural Parameters and Antioxidant Potential of Leavened and Unleavened Bread
Authors: Gonçalves Cibely Maria , de Souza Cínthia Hoch Batista , Suguimoto Hélio Hiroshi , Ishii Priscila Lumi , dos Santos Leandro Freire 
Published: March 2017

Abstract
The purpose of the study was to determine (1) whether baking process (a unit operation) – applied to produce leavened (LFB) and unleavened bread (UFB) – modifies the bioactivity of whey protein (WP) added in these portions and (2) how whey protein can change the textural parameters of these formulations. Reducing power activity (antioxidant potential) in food matrix was evaluated using phosphomolybdenum method. Textural parameters – hardness, cohesiveness, springiness, resilience, chewiness and gumminess – were carried out on a texture analyzer. In addition, this study demonstrated that the biofunctionality of whey protein was maintained in UFB 10 % WP. Nonetheless, this same formulation showed high values of textural parameters (hardness, chewiness and gumminess). Regarding the LFB formulations, the antioxidant potential was restricted after baking process in LFB 10 % WP. In conclusion, addition of bioactive additive in food matrix may not be sufficient to turn it into a functional food considering the effect of unit operations on bioactivity of some potential additives.
Sprachliche Studierfähigkeit: ein Konstrukt auf dem Prüfstand
Authors: Wollert Mattheus , Zschill Stephanie 
Published: March 2017

Zusammenfassung
Dieser Artikel berichtet über ein Projekt des Internationalen Studienzentrums der Goethe Universität Frankfurt am Main zur Überprüfung der Konstruktvalidität der DSH. Dem Testkonstrukt der DSH liegen die sprachlichen Fähigkeiten zugrunde, die ausländische Studierende aufweisen müssen, um ein Studium in Deutschland aufnehmen zu können: die sprachliche Studierfähigkeit. Sie ist konstitutiv für die Sozialisierung in den wissenschaftlichen Alltag an deutschen Hochschulen. Allerdings sind zentrale Anforderungen der sprachlichen Studierfähigkeit noch nicht ausreichend untersucht worden. Ausgangspunkt des Projekts sind deshalb linguistische Untersuchungen zu dem in der DSH-Prüfungspraxis verwendeten sprachlichen Material. Dabei berichten wir hier über eine exemplarische Gegenüberstellung von Prüfungsmaterial aus dem Teilbereich des Leseverstehens und der wissenschaftssprachlichen Strukturen mit authentischen Beispielen der alltäglichen Wissenschaftssprache mittels funktional-pragmatischer Analysekategorien.