bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a peer-supported, self-management intervention for people following mental health crisis
Authors: Milton Alyssa , Lloyd-Evans Brynmor , Fullarton Kate , Morant Nicola , Paterson Bethan , Hindle David , Kelly Kathleen , Mason Oliver , Lambert Marissa , Johnson Sonia 
Published: November 2017

Abstract
Background
A documented gap in support exists for service users following discharge from acute mental health services, and structured interventions to reduce relapse are rarely provided. Peer-facilitated self-management interventions have potential to meet this need, but evidence for their effectiveness is limited. This paper describes the development of a peer-provided self-management intervention for mental health service users following discharge from crisis resolution teams (CRTs).

Methods
A five-stage iterative mixed-methods approach of sequential data collection and intervention development was adopted, following the development and piloting stages of the MRC framework for developing and evaluating complex interventions. Evidence review (stage 1) included systematic reviews of both peer support and self-management literature. Interviews with CRT service users (n = 41) regarding needs and priorities for support following CRT discharge were conducted (stage 2). Focus group consultations (n = 12) were held with CRT service-users, staff and carers to assess the acceptability and feasibility of a proposed intervention, and to refine intervention organisation and content (stage 3). Qualitative evaluation of a refined, peer-provided, self-management intervention involved qualitative interviews with CRT service user participants (n = 9; n = 18) in feasibility testing (stage 4) and a pilot trial (stage 5), and a focus group at each stage with the peer worker providers (n = 4).

Results
Existing evidence suggests self-management interventions can reduce relapse and improve recovery. Initial interviews and focus groups indicated support for the overall purpose and planned content of a recovery-focused self-management intervention for people leaving CRT care adapted from an existing resource: The personal recovery plan (developed by Repper and Perkins), and for peer support workers (PSWs) as providers. Participant feedback after feasibility testing was positive regarding facilitation of the intervention by PSWs; however, the structured self-management booklet was underutilised. Modifications to the self-management intervention manual and PSWs’ training were made before piloting, which confirmed the acceptability and feasibility of the intervention for testing in a future, definitive trial.

Conclusions
A manualised intervention and operating procedures, focusing on the needs and priorities of the target client group, have been developed through iterative stages of intervention development and feedback for testing in a trial context.
Trial Registration ISRCTN01027104 date of registration: 11/10/2012
Complete genome sequence of Pseudomonas corrugata strain RM1-1-4, a stress protecting agent from the rhizosphere of an oilseed rape bait plant
Authors: Zachow Christin , Müller Henry , Laireiter Christina M. , Tilcher Ralf , Berg Gabriele 
Published: November 2017

Abstract
Pseudomonas corrugata
strain RM1-1-4 is a rhizosphere colonizer of oilseed rape. A previous study has shown that this motile, Gram-negative, non-sporulating bacterium is an effective stress protecting and biocontrol agent, which protects their hosts against abiotic and biotic stresses. Here, we announce and describe the complete genome sequence of P. corrugata RM1-1-4 consisting of a single 6.1 Mb circular chromosome that encodes 5189 protein coding genes and 85 RNA-only encoding genes. Genome analysis revealed genes predicting functions such as detoxifying mechanisms, stress inhibitors, exoproteases, lipoproteins or volatile components as well as rhizobactin siderophores and spermidine. Further analysis of its genome will help to identify traits promising for stress protection, biocontrol and plant growth promotion properties.
Ultrasonic velocity measurements on thin rock samples: Experiment and numerical modeling
Authors: Yurikov Alexey , Lebedev Maxim , Pervukhina Marina 
Published: November 2017

The ultrasonic pulse transmission (UPT) method has been the gold standard for laboratory measurements of rock elastic properties for decades, and it is used by oil and gas industry and service companies routinely. In spite of the wide acceptance and use of the UPT method, experimentalists are still looking for ways to further extend the limits of its applicability and to improve its state-of-the-art practices. One of the problems that limits wider application of the method is the length of the standard samples used (approximately 40–100 mm). This is a crucial limitation either in the case of a damaged core when preparation of a standard size sample is impossible or in the case when an ultrasonic experiment is combined with saturation or desiccation processes that might be extremely time-consuming on the long samples. On the other hand, thinner samples are not typically used due to the implication of inhomogeneity of stress fields inside and whereas few results of the measurements on thin disc samples have been reported in the literature, detailed justifications of the procedures have not been done yet. To fill this gap, we compare ultrasonic velocities measured at confining stresses up to 50 MPa done on standard and thin samples with lengths of 60 and 15 mm, respectively. First, we evaluate a new developed experimental setup for ultrasonic measurements on thin discs and develop a detailed experimental procedure. Then, we use finite-element modeling to numerically simulate stress fields in both types of samples. Finally, we compare the ultrasonic velocities measured on the thin discs and on standard samples and determine how to obtain reliable elastic properties on thin samples.
Characteristics and origin of the Sinian-Permian fault system and its controls on the formation of paleo-carbonate reservoirs: A case study from Central Paleo-Uplift, Sichuan Basin, China
Authors: Li Wenke , Wang Jun , Li Jinsong , Liu Xiaohong , Chen Kang , He Qinglin 
Published: November 2017

We have evaluated the existence of good paleo-carbonate reservoirs in fault damage zones with a burial depth exceeding 5800 m in the Central Paleo-Uplift, Sichuan Basin, China. The relationships between fault system and sedimentation, and the formation of the paleo-carbonate reservoirs have been explored, which have long been ignored by previous studies due to the low-quality seismic data and the prevalent assumption of weak tectonic movement. Data from different sources such as newly acquired and processed seismic data, cores, and well-logs are used to study the characteristics and origin of the fault system and their controls on the formation of paleo-carbonate reservoirs. The main findings are as follows: (1) The Sinian-Permian fault system in the study area mainly comprises strike-slip faults with different scales plus a small number of locally developed collapse-related concentric faults. (2) The Sinian-Permian fault system, which usually has normal throw, mainly developed in an extensional stress field and its evolution spanned five stages including the basement-fault formation stage in the Yangtze cycle, extensional dextral strike-slip faults formation stage in the Xingkai cycle, weakly compressional sinistral strike-slip faults formation stage in the Caledonian cycle, extensional faults formation stage in the Hercynian cycle, and compressional transformation stage in the Indosinian-Himalayan cycles. Most faults formed in the Xingkai and Caledonian cycles, whereas the Indosinian-Himalayan cycles had a weak effect on the Sinian-Permian fault system in the study area. (3) Different types of faults have different effects on the sedimentation, formation, and preservation of the paleo-carbonate reservoirs. The synsedimentary faults provide necessary tectonic background for the sedimentation of high-energy facies, whereas the successive faults and coalesced fractures determine the formation, distribution, and preservation of the porous karst carbonate reservoirs. The basement faults controlling the hydrothermal fluids only cause partial filling of the existing pore spaces; thus, most pore spaces in the karst carbonate reservoirs are able to be preserved. Therefore, the fault damage zones within the paleo-carbonate strata produce good reservoirs and important exploration targets.
ImaEdge – a platform for quantitative analysis of the spatiotemporal dynamics of cortical proteins during cell polarization
Authors: Zhang Zhen , Lim Yen Wei , Zhao Peng , Kanchanawong Pakorn , Motegi Fumio 
Published: November 2017

ABSTRACT
Cell polarity involves the compartmentalization of the cell cortex. The establishment of cortical compartments arises from the spatial bias in the activity and concentration of cortical proteins. The mechanistic dissection of cell polarity requires the accurate detection of dynamic changes in cortical proteins, but the fluctuations of cell shape and the inhomogeneous distributions of cortical proteins greatly complicate the quantitative extraction of their global and local changes during cell polarization. To address these problems, we introduce an open-source software package, ImaEdge, which automates the segmentation of the cortex from time-lapse movies, and enables quantitative extraction of cortical protein intensities. We demonstrate that ImaEdge enables efficient and rigorous analysis of the dynamic evolution of cortical PAR proteins during Caenorhabditis elegans embryogenesis. It is also capable of accurate tracking of varying levels of transgene expression and discontinuous signals of the actomyosin cytoskeleton during multiple rounds of cell division. ImaEdge provides a unique resource for quantitative studies of cortical polarization, with the potential for application to many types of polarized cells.
This article has an associated First Person interview with the first authors of the paper.
Naïve and sophisticated long-term readings of foreign and national films viewed in a Mexican northern town during the 1930–60s
Authors: Lozano José Carlos , Biltereyst Daniel , Meers Philippe 
Published: November 2017

Abstract
The memories and recollections of films viewed in the past have not been as frequently and as comprehensively examined as the decoding and appropriation of contemporary movies by media and cultural studies scholars, despite the value of gathering long-term evidence of accumulated readings and meanings audiences attach to specific types of contents or media experiences. By analysing the recollection of 28 Mexican elders about foreign and national films seen when they were kids or youngsters, this article evaluates their degree of acceptance, negotiation or rejection not of single movies but of types of films according to their origin or genre.
Neutropenia and T-Wave Inversion as Toxin-Mediated Complications of a Streptococcal Infection
Authors: Popescu Cristina , Leuştean Anca , Orfanu Alina Elena , Carp Codruţa Georgiana , Aramă Victoria 
Published: November 2017

Abstract

Introduction: Streptococcal infection can be responsible for multiple complications, such as toxic, septic or allergic disorders. Toxin-mediated complications (TMC) can appear during the acute phase of disease and can involve any organ, causing carditis, arthritis, nephritis, hepatitis etc.

Case presentation: The case of a young woman without a history of recurrent streptococcal tonsillitis, admitted to “Matei Balş” National Institute for Infectious Diseases, Bucharest, Romania, presenting with fever, sore throat and exudative tonsillitis, is detailed. The initial test for Streptococcus pyogenes was negative. The patient had leukopenia with severe neutropenia, high values of inflammatory biomarkers and electrocardiographic (ECG) changes with inverted T waves in leads V1-4 and flattened T waves in V5-6. There were no other cardiac signs or symptoms. The patient received cefuroxime for two days. On admission, the patient was prescribed Penicillin G and dexamethasone which resulted in a rapid recovery. The leucocytes count returned to normal as did the ECG abnormalities. At the time of discharge, the antistreptolysin O titre was high.

Conclusions: The case highlights the toxin-mediated complications (TMC) of streptococcal infection which occur from the outset of the disease.
Computer-Aided Diagnosis in Colorectal Cancer: Current Concepts and Future Prospects
Authors: Ioanovici Andrei-Constantin , Feier Andrei-Marian , Țilea Ioan , Dobru Daniela 
Published: November 2017

Abstract
Colorectal cancer is an important health issue, both in terms of the number of people affected and the associated costs. Colonoscopy is an important screening method that has a positive impact on the survival of patients with colorectal cancer. The association of colonoscopy with computer-aided diagnostic tools is currently under researchers’ focus, as various methods have already been proposed and show great potential for a better management of this disease. We performed a review of the literature and present a series of aspects, such as the basics of machine learning algorithms, different computational models as well as their benchmarks expressed through measurements such as positive prediction value and accuracy of detection, and the classification of colorectal polyps. Introducing computer-aided diagnostic tools can help clinicians obtain results with a high degree of confidence when performing colonoscopies. The growing field of machine learning in medicine will have a big impact on patient management in the future.
Simultaneous Determination of Carbamazepine and Carbamazepine-10,11-epoxide in Different Biological Matrices by LC-MS/MS
Authors: Andonie Dan , Gáll Zsolt , Bosa Paul , Dogaru Maria Titica , Vancea Szende 
Published: November 2017

Abstract
An uncomplicated, sensitive liquid chromatography linked to mass spectrometry (LC/MS) for evaluation of carbamazepine and carbamazepine-10,11-epoxide (its metabolite) in human plasma, human saliva, rat plasma, and rabbit plasma was developed. Analyses were conducted on a Zorbax SB-C18, 100 mm × 3 mm ID, 3.5 μm column, at a column temperature of 40 ºC. The mobile phase was comprised of 0.1% formic acid in water and methanol in a 35 : 65 (v/v) ratio, with a flow rate of 0.4 mL/min. Lacosamide was utilized as internal standard. Under these chromatographic conditions, the retention times of lacosamide, carbamazepine-10,11-epoxide, and carbamazepine were 1.4 min, 1.6 min, and 2.2 min, respectively. The quantification of the analytes was performed using multiple reaction monitoring, with the use of a triple quadrupole mass spectrometer with electrospray positive ionization. The monitored ions were m/z 194 derived from m/z 237 for carbamazepine, m/z 180 derived from m/z 253 for carbamazepine-10,11-epoxide, and m/z 108 derived from m/z 251 for lacosamide. The samples were prepared by protein precipitation from 0.2 mL of plasma/saliva using 0.6 mL of internal standard solution in methanol. Calibration curves were constructed over the ranges 1.1–17.6 µg/mL and 0.23–5.47 µg/mL for carbamazepine and carbamazepine-epoxide, respectively. The coefficients of determination obtained by using a weighted (1/x) linear regression were greater than 0.994. The reported LC-MS/MS method was applied to preclinical pharmacokinetic studies and therapeutic drug monitoring.
Intracoronary Shear Stress and CT Characteristics of Vulnerable Coronary Plaques
Authors: Benedek Annabella 
Published: November 2017

Abstract
Vulnerable coronary plaques are associated with a significant risk for rupture, and the ability to detect their characteristic features is of extreme importance, as timely detection of rupture-prone plaques could lead to the appropriate initiation of adequate therapeutic measures and prevent the evolution to an acute coronary event. The most common features of vulnerability in coronary plaques are represented by the presence of low density atheroma, a thin fibrous cap, spotty calcifications, and positive remodeling. However, there is still a huge amount of information to be learned about the role of local forces, represented by the shear stress, on the plaque vulnerability. This clinical update aims to present the most recent advances in the field of knowledge regarding the relation between shear stress and plaque vulnerability, starting from the hypothesis that shear stress significantly correlates with the CT features of plaque vulnerability and can represent a new marker of vulnerability in coronary artery plaques.
Performance Analysis of Hybrid Optical Amplifiers for 32 Channel WDM System at 10 Gbps Bit Rate for WAN Applications
Authors: Apoorva  , Priyanka  , Wadhwa Himanshu , Kaur Gurjit 
Published: November 2017

Abstract
In this paper, we have simulated an optical 32 channel WDM system with 10 Gbps data rate for various hybrid amplifiers at varying lengths. Stand-alone EDFA gives better performance than other individual amplifiers but when hybrid with Raman amplifier, the performance of the WDM system is enhanced. A lot of researchers are working on the hybrid amplifiers like EDFA and Raman. In this research paper we have also included latest amplifier such as Ytterbium and Praseodymium amplifiers and the performance of the various hybrid combinations is compared. So, different hybrid amplifiers such as Raman-EDFA, EDFA-Yb, Raman-Yb, EDFA-Pr and Raman-Pr have been analyzed for performance parameters like quality factor, bit error rate, eye height and channel power. The analysis shows that EDFA-Pr has maximum Q-factor of 15.4883 at 80 km. EDFA-Pr has a maximum eye opening of 0.00534 at 80 km of length but at 120 km transmission distance EDFA-Yb shows maximum eye opening of 0.00154. Below 100 km of transmission distance, EDFA-Pr shows minimum BER value ranging from 10–54 to 10–20 but as the length is increased above 100 km EDFA-Yb shows better performance with values ranging from 10–16 to 10–09.
Potential Immune Biomarkers in Diagnosis and Clinical Management for Systemic Lupus Erythematosus
Authors: Zecevic Lamija , Karamehic Jasenko , Coric Jozo , Stubljar David , Avdagic Nesina , Selmanovic Kenan , Jukic Tomislav , Savic Sinisa 
Published: November 2017

SummaryBackground:There is still no reliable, specific biomarker for precision diagnosis and clinical monitoring of systemic lupus erythematosus. The aim of this study was to investigate the importance of the determination of immunofenotypic profiles (T, B lymphocytes and NK cells) and serum cytokine concentrations (IL-17 and IFN-alpha) as potential biomarkers for this disease.Methods:The study included 55 patients with SLE and 25 healthy controls. The proportion of T, B, NK cells were assessed in peripheral blood using flow cytometric assays while the serum cytokine concentration (IL-17 and IFNalpha) was determined by ELISA test.Results:ROC curve analysis showed good accuracy to distinguish between patients and healthy individuals for activated T cells (AUC=0.798; p<0.001), Treg (AUC= 0.651; p=0.036), and memory B cells (AUC=0.285; p=0.002). We found statistically significant difference (p=0.036) in the levels of serum IL-17 between patients with SLE (IL-17=49.27 pg/mL) and controls (IL-17= 28.64 pg/mL).Conclusions:Significant increase in the relative number of Treg lymphocytes, and decrease in memory B cells, as well as decrease level of IL-17, in SLE patients may be implicated in the pathogenesis of the disease. These parameters, as biomarkers, could distinguish SLE patients and no-SLE patients. Monitoring subpopulations of immune cells in peripheral blood using flow cytometry provides insight into abnormal T and B cell function in SLE. Progress in understanding the immunity at SLE, results in concrete benefits for the SLE patients, which include new clinical management and therapeutic strategies.
English language schooling, linguistic realities, and the native speaker of English in Hong Kong
Authors: Hansen Edwards Jette G. 
Published: November 2017

Abstract
The study employs a case study approach to examine the impact of educational backgrounds on nine Hong Kong tertiary students’ English and Cantonese language practices and identifications as native speakers of English and Cantonese. The study employed both survey and interview data to probe the participants’ English and Cantonese language use at home, school, and with peers/friends. Leung, Harris, and Rampton’s (1997, The idealized native speaker, reified ethnicities, and classroom realities. TESOL Quarterly 31(3). 543–560) framework of language affiliation, language expertise, and inheritance was used to examine the construction of a native language identity in a multilingual setting. The study found that educational background – and particularly international school experience in contrast to local government school education – had an impact on the participants’ English language usage at home and with peers, and also affected their language expertise in Cantonese. English language use at school also impacted their identifications as native speakers of both Cantonese and English, with Cantonese being viewed largely as native language based on inheritance while English was being defined as native based on their language expertise, affiliation and use, particularly in contrast to their expertise in, affiliation with, and use of Cantonese.
Der medizinische Unterricht der Iatrosophisten in der ‚Schule von Alexandria‘ (5.‒7. Jh. n. Chr.): Überlegungen zu seiner Organisation, seinen Inhalten und seinen Ursprüngen (erster Teil)
Authors: Overwien Oliver 
Published: November 2017

Abstract
A reconstruction of the medical instruction of the iatrosophists in Alexandria (5th–7th century) faces serious problems, because the sources provide us with no information on either their organisation or the biographies of their teachers. Nonetheless, some key points can be established that were characteristic of the teaching of the iatrosophists. These include the medical curriculum, the textbooks used, the type of lectures, the practical training, and the teaching units on philosophical themes. Further, it seems that Gessius initiated this type of teaching, and in the process made numerous borrowings especially from his philosophy teacher Ammonius. Ultimately, the rise in the teaching of the iatrosophists can be explained by different innovations in educational politics that can also be detected in other parts of the Roman Empire at the same time.
Schiffbruch im Totenreich
Authors: Sprengel Peter 
Published: November 2017

Abstract
In Hauptmann’s reception of antiquity there is an overlap between the ‘dark’ (i.e. chthonic, Dionysiac, barbaric) understanding of the Greeks, which had been introduced by Bachofen and Nietzsche and which was characteristic of modernism as a whole around 1900, and a late neoclassical view of the Hellenic legacy, which is manifested not least in his drawing on the literary translations of the nineteenth century (in the case of the three tragedians, Donner’s translations “in the original metres”). The same tension is a feature also of his late Atrides Tetralogy. Its second part, Agamemnons Tod (‘Agamemnon’s Death’) not only recurs to Aeschylus’ Oresteia, to which Hauptmann had responded with enthusiasm in his youth, but is also influenced by the chthonic Homer interpretation of his first drama on a theme from the ancient world, Der Bogen des Odysseus (‘Odysseus’ Bow’), and by nineteenth-century archaeology at Mycenae.