bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute-Phase Recording of the Spreading Depolarization Continuum in Aged Nonhuman Primates During Focal Ischemic Stroke
Authors: Sword Jeremy J. , Sparks Tyler , Debs Luca H. , Major Sebastian , Sharma Suash J. , Jensen Michael A. , Moore-Hill Debra T. , Barton Karen , Shah Manan , Garcia Klepper Alfredo , Switzer Jeffrey A. , Blake David T. , Vale Fernando L. , Dreier Jens P. , Hartings Jed A. , Kirov Sergei A. 
Published: February 2025

BACKGROUND:
Decades of experimental and clinical data revealed that spreading depolarizations (SDs) play a central causal role in the development of cortical lesions after acute brain injury. However, clinical documentation of events at the onset of focal ischemic stroke and during the initial phase of cortical injury development is lacking because electroencephalography monitoring of SD typically starts hours or days later. Here, we used nonhuman primates to map electrophysiological pathology through focal ischemic stroke’s onset and acute stage.

METHODS:
Craniotomies were performed over both hemispheres on 4 male and 1 female nemestrina and rhesus macaques aged 23 years to 32 years. Subdural electrode arrays were placed bilaterally over the middle cerebral artery territory, recording from 24 electrodes 1 cm apart on the left cortex and 7 on the right. After 30 minutes of baseline monitoring, the left middle cerebral artery and, in some cases, also the left internal carotid or anterior cerebral arteries were permanently occluded with aneurysmal clips.

RESULTS:
Repetitive SDs occurred during the next 3 hours, followed by terminal SD during euthanasia. No epileptiform activity was observed in any of the 5 animals. Nonspreading electrical silence developed in the ischemic core within seconds of ischemic onset, followed by terminal SD and SD-initiated negative ultraslow potential after several minutes. These events defined the ischemic core and led to histologically confirmed cell damage. Initial and subsequent transient SDs caused spreading depression of spontaneous activity in the normally perfused surrounding cortex without any signs of histological damage. Cardiocirculatory arrest at the end of experiments first induced nonspreading depression of activity followed by SD and, eventually, the SD-initiated negative ultraslow potential, which indicated brain death.

CONCLUSIONS:
Results in gyrencephalic nonhuman primates hold significant implications for understanding the role of SD in acute brain injury development and for the clinical translation and diagnosis of pathologies manifested in the SD continuum.
Familiarity dampens the effect of boldness on coordination in three-spined sticklebacks
Authors: Riley Riva J. , Kwon Young Mi , Manica Andrea , Savage James L. 
Published: February 2025

Abstract
Group-living animals must coordinate with other group members to reap the benefits and avoid the costs of social living, but precisely how individuals should respond to one another is mediated by interacting social and environmental factors. In stable groups, familiarity (i.e. prior experience with particular conspecifics) often improves group coordination, with familiar groups outperforming unfamiliar groups in foraging efficiency and predator evasion. Group coordination is also affected by individual behavioural tendencies, and consistent individual differences such as boldness drive specific coordination behaviours including leadership. Furthermore, in stable groups these consistent differences in behaviour (or ‘personalities’) facilitate individuals predicting each other’s behaviour as they can learn their groupmates’ behavioural tendencies over time. Few studies have investigated how familiarity and personality interact to influence behaviour in social groups. Here, we assess how familiarity differentially affects ‘bold’ and ‘shy’ individuals in pairs of three-spined sticklebacks (Gasterosteus aculeatus). Our results show that familiarity modifies how individuals coordinate with their partners, and that leadership dynamics are determined by boldness levels in unfamiliar pairs, but not in familiar pairs. This suggests that familiarity with others in social groups alters the leadership tendencies of individuals, with implications for how personality interacts with the social environment to determine individual coordination behaviour.
Gut detoxification and antioxidant responses in laying hens supplemented with phytogenics
Authors: Anagnostopoulos E.C. , Mountzouris K.C. 
Published: February 2025

Abstract
This study evaluated the effects of a phytogenic blend (PB) on the performance and critical genes relevant to the detoxification (i.e. aryl hydrocarbon receptor pathway) and antioxidant responses (i.e. nuclear factor erythroid 2-related factor 2 pathways) in the duodenum and the caeca of laying hens. The PB consisted of selected Mediterranean plants containing olive oil polyphenols, carvacrol and thymol among its main bioactive components. A total of 385, 21-week-old Hy-Line Brown layers were assigned to one of five dietary treatments with seven replicates of 11 hens each for a 12 week feeding experiment. The experimental treatments included a control corn-soybean meal basal diet with no PB (C) or supplemented with PB at 250 (PB250), 750 (PB750), 1000 (PB1000) or 1,500 mg/kg diet (PB1500). During the experimental period, the 0–6 weeks laying rate, egg mass, feed intake and FCR did not differ among the treatment groups. For the period 7–12 weeks, laying rate, egg mass and FCR were significantly increased with PB inclusion compared to birds fed the C diet. In the duodenum and the caeca, increasing dietary PB concentration beneficially affected (P≤0.05) the expression of the majority of the AhR and Nrf2 pathway genes studied. Phytogenic inclusion modulated the layer adaptive cytoprotection in the gut and documented further the improved production, with PB750 displaying optimal benefits. In conclusion, PB inclusion beneficially modulated the layer adaptive cytoprotection in the gut which improved performance, with PB750 displaying the optimal benefits.
Creating Novel, Responsible, and Impactful Entrepreneurship Education Models
Authors: Henry Colette , Mansilla Ester Bernadó , Singer Slavica , Gabriel Barbara , Valente Robertt , Moberg Kåre , Tomasi Sabrina , Planck Sebastian , Sailer Klaus 
Published: February 2025

Abstract
In this article, we ask: How can universities create novel responsible, and impactful entrepreneurship education models? Answering this question could enhance the take-up and relevance of entrepreneurship education, encouraging students, academics, entrepreneurs and, indeed, every citizen, to use their skills to address society’s grand challenges. We adopt an in-depth case approach to critically explore the EU-funded ‘Start for Future’ (SFF) alliance, an entrepreneurship and innovation mega-ecosystem that brings universities together to deliver entrepreneurship education in SDG-related domains. Our article contributes by: 1) enhancing understanding of the critical role universities play as entrepreneurial changemakers, driving social, economic and technological transformation; 2) augmenting the growing body of scholarship on entrepreneurship education, specifically illuminating the responsibility dimension in driving impactful entrepreneurship; 3) drawing attention to a novel, playful yet highly impactful entrepreneurship education model – Start for Future – one built on the principles of responsible entrepreneurship, reciprocity, mutual learning, co-creation and experimentation.
Kierkegaard, the Forerunner of Presuppositional Apologetics
Authors: Oganessian Armen 
Published: February 2025

Abstract
This paper argues that Kierkegaard critiques both inductive and deductive arguments for establishing biblical truths. His contention with them arises from his belief that the human mind, restricted by its cognitive limitations, lacks the requisite categories to know God. Essentially, without the incarnation of Christ, the human intellect lacks the object for the subject of theology. This, coupled with his belief that one can only directly encounter Christ in the Bible, leads Kierkegaard to advocate for a reliance on Scripture as the sole source of knowledge of God. He argues that proofs, whether historical or speculative, create an epistemological barrier between the individual and Christ. Historical arguments, in Kierkegaard’s view, treat truth as a mere hypothesis, thereby distancing believers from a genuine encounter with God. Likewise, speculative proofs, by abstractly presenting Christian truths, create a similar distance. Thus, I contend that Kierkegaard should be recognized as a precursor to presuppositionalism.
A 42-yr statistic on the Dabie vortices: Multi-scale temporal characteristics and associated mechanisms, and hourly-rainfall features
Authors: Fu Shen-Ming , Zhang Jing-Ping , Xiao Xue , Huang Ting-Ting , Sun Jian-Hua 
Published: February 2025

Abstract
Over the middle reaches of the Yangtze River Basin, there are an important type of mesoscale vortices, which are referred to as the Dabie vortex (DBVs). DBVs has formed a research focus for decades, as they frequently induce flash-flood-producing rainstorms along their tracks. However, of all existing DBVs-related studies, none have ever investigated DBVs’ long-term climatological features, and all the basic features of DBVs are obtained from shortterm statistics and/or case studies. To partly fill these knowledge gaps, we conduct a 42-yr statistical study on the DBVs by using the hourly ERA5 reanalysis data. New findings mainly include the follows: On an interdecadal scale, from 1983 to 2016, DBVs’ occurrence frequency shows a significant increasing trend of ∼0.3 DBV a−1, which may correspond to the enhancing horizontal transport of vorticity by the intensifying summer monsoon (a trend of 0.23 d−1 in summer-monsoon index). Monthly variation of DBVs’ occurrence/appearance frequency (maximizes in June) is consistent with monthly variations of summer monsoon and its associated divergence, which affect DBVs’ formation through vertical stretching. DBVs’ diurnal variation shows two peaks at 2200 UTC (∼9.8% in proportion) and at 1000 UTC (∼6.8%), respectively, with the former more stable than the latter. Both local diurnal variation and nonlocal forcings are crucial for producing these two peaks. As rainfall intensity grows, the relative importance of DBVs’ contribution increases from ∼13.6% (accumulated precipitation) to ∼71.5% (heaviest precipitation) within DBVs’ source region. Inside/outside source region, ∼15.2%/∼1.4% of the strongest local hourly precipitation is directly related to the DBVs.
Investigation of concentration dependent property variations of High Density Polyethylene/Styrene Ethylene Butylene Styrene blends
Authors: M Divine Sharon , R Joseph Bensingh 
Published: February 2025

Binary polymer blends of High Density Polyethylene (HDPE) and Styrene Ethylene Butylene Styrene (SEBS) are developed by varying the SEBS concentration from 1 to 10 wt%. The relation between the concentration of SEBS in HDPE and the physical, mechanical, and thermal properties of the resulting blends has been investigated. The physical properties almost remain unaffected by the addition of SEBS to HDPE. In mechanical characterization, a reduction in modulus is observed with each incremental addition of SEBS. Blends with 10% SEBS concentration reveal a nine fold increase in tensile elongation along with a 15.4% and 26.4% increase in room and low temperature impact resistance. In thermal characterization, Thermogravimetric Analysis (TGA) of the polymer blends reveals a slight decline in thermal stability with increasing SEBS concentration. Heat Deflection Temperature (HDT) declines sharply beyond 5 wt% SEBS concentration, thermograms obtained from Differential Scanning Calorimetry (DSC) portray an increase in crystallinity till 5 wt% and then declines with further addition of SEBS. A temperature and composition dependent molecular mobility between the polymer phases is evident from Dynamic Mechanical Analysis (DMA). A transition from immiscible two phase droplet-matrix separation phase to a partially miscible morphology is evident from analysis under Scanning Electron Microscope (SEM).
Case Report of a Primary Sinonasal Renal Cell-Like Adenocarcinoma With EWSR1 Gene Rearrangement in a 13-Year-Old Male
Authors: Tang Ming , Yao Hong , Yang Chao , Liu Peng-Jie , Yang Xuan-Tao 
Published: February 2025

Background: Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a rare, low-grade malignant neoplasm originating in the nasal cavity and paranasal sinuses. This report provides a detailed account of the clinical and pathological characteristics of a single case of SNRCLA, highlights its differential diagnosis, and includes a review of relevant literature. Case description: A 13-year-old male presented with a mass in the right nasal cavity. Histopathological analysis demonstrated tumor morphology analogous to clear cell renal cell carcinoma, characterized by abundant clear cytoplasm, acinar formations, and a prominent capillary-rich stroma. Immunohistochemical analysis revealed positive staining for cytokeratin pan, cytokeratin 7, vimentin, carbonic anhydrase IX, and SRY-box 10, with partial positivity for S-100. Markers such as paired box 8, atriopeptidase, renal cell carcinoma marker, melanosome, thyroglobulin, and thyroid transcription factor-1were negative. Fluorescence in situ hybridization analysis identified the presence of an EWSR1 gene rearrangement. The patient underwent surgical resection followed by adjuvant radiotherapy. Follow-up evaluations conducted as of November 2024 revealed no evidence of tumor recurrence, and the patient remained in good general health. Conclusion: SNRCLA is a rare neoplasm characterized by its low incidence rate and the necessity for exclusion-based diagnosis, requiring differentiation from other clear cell tumors. Immunohistochemistry plays a key role in establishing the diagnosis and distinguishing SNRCLA from histologically-similar entities. This case represents the first documentation of EWSR1 gene rearrangement in SNRCLA, thereby contributing novel insights into its molecular profile.
The Oxford Visual Perception Screen: Development and normative data of a standardised assessment for visual perception difficulties
Authors: Vancleef Kathleen , Castellani Ruby , Shorthose Rebecca , Guo Catherine , Cai Merak Fulin , Guazzo Federica , Demeyere Nele 
Published: February 2025

Objective We aimed to develop and standardise a practical systematic screening tool for visual perception impairments after a stroke to replace current subjective methods. Design A mixed methods study including a cross-sectional study and a case series. Setting In the community and on stroke rehabilitation units. Participants Older volunteers without a neurological history contributed to normative data. Patients with ocular conditions or a stroke took part in our case series. Instrument The Oxford Visual Perception Screen. Main measures For each task of the Oxford Visual Perception Screen, we determined 5th centile cut-off scores. We further explored effects of age, visual acuity and gender on visual perception through generalised linear models. Results Oxford Visual Perception Screen is a 15-min paper-and-pen assessment comprising 10 tasks including picture naming, star counting and reading. Normative data of 107 participants demonstrated persistent high performance with most cut-offs near ceiling. Apart from the Figure Copy ( Z = 6.57, p < 0.001) and Global Shape Perception task ( Z = 3.32, p < 0.001) we found no evidence for an effect of visual acuity on OxVPS. An effect of age was only observed in the Face Recognition ( Z = 3.61, p < 0.001) and Reading task ( Z = −3.50, p < 0.001). No effects of gender were observed. A series of eight cases illustrates the interpretation of OxVPS. Conclusion We present the Oxford Visual Perception Screen, a standardised visual perception screening tool alongside normative data and illustrative cases. The Oxford Visual Perception Screen can potentially change screening for visual perception impairments in clinical practice and is available at https://oxvps.webspace.durham.ac.uk/ .
Mechanical and thermal characterization of polymeric films formed in deuterated ionic liquids
Authors: Al-Haik Mohammad Y 
Published: February 2025

This paper investigates the impact of deuterated ionic liquids (ILs) on the characterization of mechanical and thermal properties of polymeric films. The polymeric films were synthesized using two types of ionic liquids: 1-N-butyl-3-methylimidazolium chloride ([BMIM]Cl) and 1-methyl-D3-3-butyl-D9-imidazolium chloride ([BMIM-d12]Cl). Six samples were prepared, comprising three concentrations (1 wt%, 3.5 wt%, and 4.5 wt%) of the two ionic liquids. The mechanical properties, stiffness, and hardness, were evaluated using a universal tensile testing machine and a nanoindenter. The thermal properties were assessed using a thermogravimetric analyzer (TGA). The results demonstrated a significant enhancement in the mechanical performance of films formed with deuterated ionic liquids, with stiffness and hardness increasing up to 90 times compared to films synthesized with non-deuterated ionic liquids. Films containing [BMIM-d12]Cl demonstrated a toughness value 7000 times higher than the films without deuterated IL. The results indicate that deuterated ILs produce more thermally stable, stiffer, and tougher films compared to similar compositions of non-deuterated ILs. This improvement highlights the influence of deuterium substitution in ionic liquid structures, likely due to altered intermolecular interactions and increased film cross-linking density.
Rehabilitation effect of aquatic exercise on motor function in children with cerebral palsy: Systematic review of randomized controlled trials
Authors: Li Fangqin , Huang Wenjiao , Li Huanhuan , Liu Zuoyan , Feng Liwei 
Published: February 2025

Background Cerebral palsy (CP) refers to a lasting motor impairment resulting from atypical brain development or injury. Aquatic exercise (AE) is frequently utilized as an approach for rehabilitating children with CP because of its appealing water properties. Objective The aim of this study was to examine how AE influences motor skills in children affected by CP. Methods Systematic searches of databases provided randomized controlled trials (RCTs) published from their inception up until May 22, 2024. The study compared the impacts of AE training with those of routine rehabilitation training (RRT). A random-effects model was employed to assess the aggregated data. Results In total, 491 articles were retrieved, and 15 studies ( n = 595 patients) were included in this study. Compared with RRT, AE improved the gross motor function of children with CP ( SMD = 7.63, 95% CI 5.79–9.47, P < 0.01), especially in the lying and turning over positions ( SMD = 15.66, 95% CI 13.85–17.46, P < 0.01). AE also reduced muscle tension ( SMD = −0.75, 95% CI −1.03–−0.47, P < 0.01). Conclusions AE is expected to improve motor function in children with CP. Moreover, this study emphasizes the need for future high-quality related studies to supplement the results and improve the conclusions.
A Randomized Controlled Trial Plus a Systematic Review and Meta-Analysis of Published Studies Evaluating a Conventional Prophylactic Regimen of Oral Dexamethasone vs Short-Course Intravenous Dexamethasone in Preventing Paclitaxel-Associated Hypersensitivity Reactions in Patients With Gynecologic Malignancies
Authors: Donkor Kofi N , Jang Hyeree , Selim Julie Hana , Ioffe Yevgeniya J. , Hong Linda J. 
Published: February 2025

Background: Hypersensitivity reactions (HSRs) are often encountered in patients receiving paclitaxel infusions. The conventional method, comprising dexamethasone 20 mg (Dex20) taken 12 and 6 hours before paclitaxel plus histamine (H)1 and H2-antagonists administered 30 minutes before paclitaxel, is an effective but cumbersome method in reducing HSRs in gynecologic oncology patients. Objective: Determine the effectiveness of a simplified premedication method (short-course) comprising Dex20 and H1 and H2 antagonists administered 30 minutes before paclitaxel vs the conventional method in preventing HSRs. Methods: The effectiveness of the short-course vs the conventional method was investigated via a Randomized Controlled Trial (RCT) and a Systematic Review and Meta-analysis by searching PubMed, EMBASE, and the Cochrane Library from inception to December 4, 2024. Primary outcomes were any-grade and grade ≥3 HSRs. Differences in effectiveness were presented as risk difference (RD) using the Mantel–Haenszel estimation and expressed with 95% confidence intervals (CIs). P-values <0.05 were considered statistically significant. The Cochrane Handbook for Systematic Reviews and Newcastle-Ottawa Score determined the quality of RCTs and observational studies. Results: Three RCTs and 2 observational studies totaling 905 patients were analyzed. The short-course method showed a significantly higher incidence of any-grade HSRs than the conventional method (RD = 7%, 95% confidence interval [CI] = 0.3% to 12.8%, P = 0.04). Although in favor of the conventional method, there was no significant difference in grade ≥3 HSRs (RD = 2%, 95% CI = −0.4% to 4.8%, P = 0.09). Subgroup analyses of RCTs showed no significant differences in any-grade HSRs (RD = 6%, 95% CI = 0.3% to 12.8%, P = 0.39) or grade ≥3 HSRs (RD = 1%, 95% CI = −1.1% to 2.4%, P = 0.48). Conclusion and relevance: The conventional method is favored over the short-course in preventing paclitaxel-associated HSRs. The short-course method is a plausible alternative for patients unable to comply with the conventional method’s requirements. Included studies were either observational studies prone to bias and inconclusive inferences or RCTs, which may not be statistically powerful enough to produce reliable results. Larger sample size prospective studies are needed to authenticate findings.