bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of neutrophil-to-lymphocyte ratio in gastric cancer patients undergoing neoadjuvant chemotherapy: A systematic review and meta-analysis
Authors: Wei Zhen-Hua , Tuo Min , Ye Chen , Wu Xiao-Fan , Wang Hong-Hao , Ren Wen-Zhen , Liu Gao , Xiang Tian 
Published: October 2024

BACKGROUND
In recent studies, accumulating evidence has revealed a strong association between the inflammatory response and the prognosis of many tumors. There is a certain correlation of neutrophil-to-lymphocyte ratio (NLR) with the prognosis in gastric cancer (GC) patients undergoing neoadjuvant chemotherapy (NAC). However, the existing research results have remained controversial.
AIM
To explore the relationship between NLR ratio and prognosis of GC patients receiving NAC.
METHODS
A thorough systematic search was performed in databases such as PubMed, Embase, Web of Science, and Cochrane Library, the search is available until February 29, 2024, and studies exploring the interaction of NLR with clinical outcomes were collected. Relevant studies meeting pre-defined inclusion and exclusion criteria were carefully chosen. The outcomes included progression-free survival (PFS), relapse-free survival, disease-free survival (DFS), and overall survival (OS). The hazard ratio (HR) and its corresponding 95% confidence interval (CI) were utilized for estimation.
RESULTS
Our analysis encompassed 852 patients and incorporated data from 12 cohort studies. The comprehensive analysis revealed a significant association of high NLR with reduced OS (HR = 1.76; 95%CI: 1.22-2.54, P = 0.003), relapse-free survival (HR = 3.73; 95%CI: 1.74-7.96, P = 0.0007), and PFS (HR = 2.32; 95%CI: 1.42-3.81, P = 0.0008) in patients. However, this correlation in disease-free survival was not significant. NLR demonstrated its crucial role in effectively predicting the OS of GC patients undergoing NAC at different detection times, ages, regions, and NLR thresholds.
CONCLUSION
In GC patients receiving NAC, an elevated NLR is strongly associated with reduced OS and PFS. NLR has become an effective biomarker for patient prognosis evaluation, providing valuable insights for the treatment strategies of NAC in GC patients.
Breast cancer imaging-clinical experience with two-dimensional-shear wave elastography: A retrospective study
Authors: Chervenkov Lyubomir , Georgiev Aleksandar , Doykov Mladen , Velikova Tsvetelina 
Published: October 2024

BACKGROUND
Breast cancer morbidity has been increasing worldwide, but treatments are improving. The therapeutic response depends on the stage at which the disease is diagnosed. Therefore, early diagnosis has never been more essential for successful treatment and a reduction in mortality rates. Radiology plays a pivotal role in cancer detection, and advances in ultrasound (US) palpation have shown promising results for breast cancer imaging. The addition of two-dimensional-shear wave elastography (2D-SWE) US in the routine breast imaging exam can increase early cancer detection and promote better surveillance.
AIM
To evaluate the clinical applications of 2D-SWE US in breast cancer detection and its combination with other imaging modalities.
METHODS
The 200 consecutive female patients aged 50-80 were examined to evaluate palpable breast lesions. All patients underwent mammography, bright mode (B-mode) US, and 2D-SWE followed by US-guided biopsy in two consecutive sessions.
RESULTS
Combining B-mode and shear wave US imaging with x-ray mammography revealed 100% of the suspicious lesions, resulting in greater sensitivity, specificity, and negative predictive value. The result improves compared to either B-mode or 2D-SWE alone (P = 0.02).
CONCLUSION
Combining 2D-SWE with conventional US and x-ray techniques improves the chance of early cancer detection. Including 2D-SWE in regular breast imaging routines can reduce the need for biopsies and improve the chance of early cancer detection and survivability with the proper line of therapy.
Exertional heat stroke with pronounced presentation of microangiopathic hemolytic anemia: A case report
Authors: Xiang Chu-Han , Zhang Xi-Mu , Liu Jie , Xiang Jun , Li Lei , Song Qing 
Published: October 2024

BACKGROUND
Exertional heat stroke (EHS) is a critical condition arising from prolonged physical exertion in high temperatures that typically presents with normal hemoglobin levels. However, atypical presentations can also occur, leading to significant complications such as hemolytic anemia and organ dysfunction.
CASE SUMMARY
This case report describes a male patient who experienced moderate-to-severe anemia that was difficult to correct, with a confirmed diagnosis of microangiopathic hemolytic anemia accompanying multiple organ dysfunction syndrome, indicative of critical EHS. Despite intensive resuscitation efforts, the patient’s condition deteriorated, necessitating admission to the intensive care unit for advanced management.
CONCLUSION
This case highlights the importance of recognizing atypical presentations of EHS, particularly that with significant hemolytic anemia and concurrent organ failure. Clinicians should maintain a high level of suspicion for these complications in patients displaying symptoms of heat-related illness, especially when caused by strenuous activity, as early diagnosis and intervention are crucial to improve patient outcomes.
Hypoparathyroidism with situs inversus totalis: A case report
Authors: Yang Mao , Pu Sheng-Lan , Li Ling , Ma Yu , Qin Qin , Wang Yan-Xia , Huang Wen-Long , Hu Hong-Ya , Zhu Mei-Feng , Li Chun-Zhu 
Published: October 2024

BACKGROUND
Hypoparathyroidism (HP) is a rare endocrine disorder, while situs inversus totalis (SIT) is a rare condition in which the internal organs are positioned in a mirrored pattern compared to their usual positions. This case illustrates some potential shared mechanisms between HP and SIT, highlighting the importance of accurate identification and prompt first emergency, offering insights for future research.
CASE SUMMARY
This report discusses a case of a middle-aged patient with adolescent-onset HP with concurrent SIT. The patient experienced recurrent episodes of increased neuromuscular excitability (manifesting as spasms in the hands and feet and laryngospasms) and even periods of unconsciousness. Initially, these symptoms led to a misdiagnosis of epilepsy. Nevertheless, upon thorough examination and treatment in the general medicine ward, the correct diagnosis was established. Corresponding treatment resulted in improved management of the patient’s symptoms.
CONCLUSION
Co-occurrence of HP and SIT may be associated with genetic mutations, chromosomal anomalies, or hereditary factors, as may other similar conditions.
Successful management of infection and macrophage activation syndrome patient using low-dose etoposide: A case report
Authors: Gao Shu-Pei , Luo Xiao-Fang , Kosari Mohammadreza , Li Wen-Juan , Yang Liu , Tu Wei , Zhong Ji-Xin 
Published: October 2024

BACKGROUND
Macrophage activation syndrome (MAS), a sub-type of hemophagocytic lymphohistiocytosis (HLH) secondary to autoimmune rheumatic diseases, is a critical and potentially fatal condition characterized by an excessive inflammatory response. Despite the established efficacy of the HLH-2004 guideline in diagnosing and treating HLH over the years, ongoing discussion persists regarding its application, especially for HLH secondary to complicated conditions, such as autoimmune rheumatic diseases combined with severe infection. Etoposide (VP-16), a topoisomerase II inhibitor that effectively induces DNA damage and subsequent apoptosis in hyperactivated immune cells, has been widely used for the treatment of HLH. However, its suppressive effect on immune system may also cause potential exacerbation of infection in autoimmune rheumatic disease-induced HLH patients complicated with severe infection. Therefore, the use of VP-16 in such cases was inconclusive.
CASE SUMMARY
In this case study, we propose a potentially effective strategy for managing a patient diagnosed with secondary HLH complicated with systemic lupus erythematosus (SLE) and chronic coronavirus disease 2019 infection. Our approach involves early administration of low-dose VP-16 (100 mg twice a week, 300 mg in total), combined with methylprednisolone, cyclophosphamide, and cyclosporine A. The administration of etoposide effectively led to improvements in various indices of HLH.
CONCLUSION
Low dose etoposide proves to be an effective approach in alleviating HLH while mitigating the risk of infection.
Cystic ductal adenocarcinoma of pancreas complicated with neuroendocrine tumor: A case report and review of literature
Authors: Zou Dong-Mei , Shu Zeng-Yi , Cao Xu 
Published: October 2024

BACKGROUND
Difficulties in making an accurate preoperative diagnosis of cystic pancreatic lesions pose a challenge for radiologists. It would be helpful to report rare cases and review the literature.
CASE SUMMARY
In the present report, a case of a patient with a pancreatic cystic lesion initially misdiagnosed as a pseudocyst by radiologist was documented, which was later pathologically confirmed as pancreatic ductal adenocarcinoma with neuroendocrine tumor. However, subsequent literature review yielded no previous reports of pancreatic ductal adenocarcinoma with neuroendocrine tumors and cystic lesions. Therefore, literature on the imaging diagnosis of pancreatic cystic lesions was instead reviewed and discussed.
CONCLUSION
Careful evaluation of the characteristics revealed by multimodal imaging techniques, medical history, laboratory examination data and follow-up observations, is critical to the diagnosis and treatment of pancreatic cystic disease. We provide valuable insights into the diagnosis of pancreatic cystic disease through a rare case report and literature review.
Analysis Of Bankruptcy Prediction Using Springate, Zmijewski, Grover. And Altman Z-Score Models On Retail Companies Listed On The Indonesia Stock Exchange
Authors: Milleniasari Poeti Annisa , Yunita Irni 
Published: October 2024

The retail sector plays a significant role and contributes greatly to the national economy. The slowdown in domestic economic growth and decreased consumer purchasing power have significantly impacted the retail business in Indonesia. This is evident from the high number of retail companies declared bankrupt and many large retail companies closing their stores. The aim of this study is to assess the health level of retail companies, determine the differences in scores among the research models, and evaluate the accuracy of the Springate, Zmijewski, Grover, and Altman models. This research is a quantitative study with a descriptive approach. The research objects are retail companies listed on the Indonesia Stock Exchange during the period 2019-2021. Sampling technique used is purposive sampling. The results of this study indicate that the highest accuracy level is achieved by the Grover model with an accuracy of 77.7%, followed by the Zmijewski model with an accuracy level of 72.2%. Meanwhile, the Springate and Altman models have the same accuracy level of 66.6%.
Nhận xét kết quả điều trị sớm sau sinh thoát vị hoành bẩm sinh
Authors: Lê Minh Trác , Trần Diệp Hà 
Published: October 2024

Mục tiêu: Nhận xét kết quả từ chẩn đoán trước sinh và điều trị sớm sau sinh trẻ thoát vị hoành bẩm sinh (TVHBS) tại Bệnh viện Phụ sản Trung ương từ 2017 đến tháng 06/2023.
Đối tượng và phương pháp: Mô tả cắt ngang 52 trẻ mắc thoát vị hoành chọn nghiên cứu.
Kết quả: 100% trẻ được chẩn đoán trước sinh, phát hiện quý 3 thai kỳ 36 trẻ (69,2%), thời điểm phát hiện thoát vị hoành trung bình là 28,6 ± 6,1 tuần. Hầu hết trẻ bị TVHBS bên trái (98,1%), không có trẻ nào bị TVHBS ở cả 2 bên. Trẻ được phẫu thuật chủ yếu từ 1 đến 4 ngày tuổi. Các biến chứng thường gặp sau phẫu thuật: viêm phổi (26,5%), nhiễm trùng huyết (24,5%), tăng áp động mạch phổi (12,2%), tràn dịch dưỡng chấp (12,2%). Thời gian thở máy sau mổ 7,6 ± 6,9 ngày, thời gian nằm viện 16,5 ± 9,6 ngày. Tỷ lệ tử vong chung: 34,6%, 5,8% tử vong trước phẫu thuật. Các nguyên nhân tử vong: tăng áp lực động mạch phổi (44,4%), nhiễm trùng (33,3%).
Kết luận: Thoát vị hoành bẩm sinh là bệnh lý có tỷ lệ tử vong cao tuy nhiên có thể chẩn đoán trước sinh sớm từ đó chuẩn bị kế hoạch xử trí kịp thời cho trẻ sau khi sinh. Nguyên nhân tử vong chủ yếu do tăng áp phổi và nhiễm trùng.
Large non-karst caves of the Altai-Sayan mountain region: morphology and genesis
Authors: Bulychov Anatoliy A. , Novikov Igor S. , Bulychova Maria A. 
Published: October 2024

In the Altai-Sayan mountain region, located in southern Siberia, there are a number of caves developed in rocks in which karst processes are impossible to occur. In East Sayan, these are the Big Oreshnaya and Dudinskaya caves, the total length of which is more than 50 km and 35 km, respectively. Within the Altai Mountains, these are the Altaiskaya and Kek-Tash caves with a total length of 4.7 and 3.2 km, respectively. Mapping of the listed caves revealed that the morphology of their passages and the general structure differ significantly from those of caves in carbonate rocks. The passages have a flattened shape in cross section. Their width is usually meters and tens of meters, vertical extension is tens and hundreds of meters, and lateral extension is hundreds of meters. In general, the pattern of the passages is arranged in a box-like structure, where the pasages fit into a system of disjoint extended subvertical planes with rare short subvertical planes connecting them. The structure of the passages of the studied caves resembles the structure of karst caves, rotated vertically by 90°. The main directions of the passages there are not aligned in subhorizontal planes, but in subvertical ones. The revealed structure corresponds to the geometry of the structural pattern of Late Cenozoic fault systems formed as a result of subhorizontal compression. Signs of abundant argillization (alteration of the initial substance by hydrothermal processes and its replacement by newly formed clay minerals) were found in the studied caves. The formation mechanism of the studied caves is offered: removal of the substrate argillized by hydrothermal processes along the fault zones, by groundwater without significant participation of karst processes.
ЎЗБЕКИСТОН РЕСПУБЛИКАСИДА КИЧИК БИЗНЕС СУБЪЕКТЛАРИ ТАРКИБИЙ ҚИСМЛАРИНИНГ БАРҚАРОР РИВОЖЛАНИШ ТАҲЛИЛИ
Authors: Абдураҳимова Саида 
Published: October 2024

Кичик бизнес субъектлари фаолиятини ривожлантириш Ўзбекистонда амалга оширилаётган иқтисодий ислоҳотларнинг энг муҳим устувор йўналишларидан бири ҳисобланади. Мақолада Ўзбекистон Республикасида қабул қилинаётган меъёрий-ҳуқуқий ҳужжатларда кичик бизнес субъектлари учун янада кенг шарт-шароитлар яратиш, уларни эркин фаолиятини таъминлаш ва амалга ошаётган ислоҳотларни янада чуқурлаштириш ҳамда либераллаштиришга йўналтирилган чора-тадбирлар ўз аксини топган бўлиб.
ZAMONAVIY DAVRDA IQTISODGA FALSAFIY QARASHLAR
Authors: Asraqulova Adiba 
Published: October 2024

Ushbu maqola iqtisodiy tafakkur ijtimoiy ong shakllari haqida bo‘lib, shaxsning zamonaviy jamiyatni moddiy va ma’naviy hayotida, xususan, kishilar o‘rtasida bo‘ladigan iqtisodiy munosabatlarni his etish, aqliy jihatdan anglab yetish va kelajakdagi o‘zgartirishlarga qaratilgan g‘oyalar, ideallar, qarashlar va nazariyalarning yaxlit tizimi ekanligini ochib berishga qaratilgan xulosalarni o’z ichiga oladi.
Photo Physical Properties of Sugar Derivatives with ICT Dye
Authors: Gayathri Somasundaram  , Kumaran Rajendran  
Published: October 2024

Photo physical techniques were employed to study hydrogen-bonding self-assemblies forming sugar derivatives interaction with 4-dicyanomethylene 2, 6-dimethyl-4H-pyran (DDP) dye in aqueous medium. Hydrogen-bonding self-assemblies were investigated by addition of sugar derivatives to DDP dye which is an Intramolecular Charge Transfer (ICT) based fluorescent probe, results in a fluorescence enhancement accompanied with a shift towards the red region. The coexistence of DDP dye with sugar derivatives signifies the presence of heterogeneous micro environment of DDP dye surrounded by varying proportion of the solute and water molecules around the dye moiety. sugar derivatives influence the excited state characteristics of DDP dye resulting in the formation and promotion of different distinguishable micro environment. The hydrophobicity of sugar derivatives along with the hydrogen-bonding properties of sugar -water and sugar - sugar largely influence the photo physical nature of DDP dye is emphasized.
Priesthood and Temple in John’s Apocalypse
Authors: Tse Timothy B. 
Published: October 2024

Timothy B. Tse argues that, while John uses language drawn from the Hebrew Bible’s descriptions of YHWH’s dwelling place, scholarship has overlooked the importance of his spatial transformation of that language. Tse thus uses theories relating to Relevance, Resistance Theory, Critical Space Theory, and Conceptual Metaphor, to demonstrate that a significant part of John’s apocalyptic strategy of resistance is to re-present his vision to his audience spatially, so that they can experience a divinely ordained alternative to the world in which they live.
Tse first demonstrates John's attempts to relegate his audience’s experience of space to his own revelation; John’s description of the visionary world creates the metaphors “the earth is a Sanctuary” and “the Saints are its priests.” Tse argues that, under this view, life on earth must be evaluated according to the concerns of the Sanctuary, which by definition requires the removal of everything impure, and the Saints (namely all Christians in both the historic and visionary worlds) must take priestly responsibility for the earth. John therefore portrays the Saints joining in the removal of all impurity upon the earth by fighting, as priests, in God and the Lamb’s war against Satan, Babylon, and all her impurities. Tse concludes that overall, John means to realign the church’s experience of space, so that they understand themselves as priests of the Sanctuary, and live according to that reality.
North Korea’s Nuclear Cinema
Authors: Shim Elizabeth 
Published: October 2024

North Korea’s Nuclear Cinemaexamines why and how North Korea has transitioned to an image-based nuclear power in the changing context of a post-Cold War world.What exactly is the North Korean nuclear threat? Why is North Korea engaging in hostilities when its erstwhile adversaries have offered a diplomatic exit ramp? Chapter by chapter, it explains how North Korea’s footage-based nuclear politics is presented as military practice, but ultimately traces its lineage to cinematic propaganda, a tradition that blurs the line between image and reality.
By leveraging cinematic resources in place of physical military mobilization, North Korea continues to move international political actors with the mere suggestion of nuclear power. At a moment when North Korea is enhancing media representation, this book dives into a timely exploration of how the regime is projecting state power as South Korean televisual media challenges the North Korean communist spectacle that has held a captive audience for decades.
Art Botany in British Design Reform, 1835-1865
Authors: Alford Sarah 
Published: October 2024

Drawing on the fields of design history and the history of science, this book examines the important role that botanical science played in the emergence of Victorian design theory.
In early 19th-century Britain, a rapid influx of plants from other countries began to confuse the orders of classification. As these new specimens arrived in nurseries and conservatories, botanists revised and promoted a new taxonomy: the Natural System. In parallel, in 1835, British manufacturers faced a government inquiry in order to improve the output of the British design industry. They needed a nationally identifiable design aesthetic and the inquiry led to the creation of the Government Schools of Design and the Design Reform movement. This book explores how, whilst botanists used drawings to clarify new systems of plant classification, designers learnt ‘art botany’, the practice of basing decorative form and ornament on the hidden, natural laws that govern plant growth and structure. Design reformers used botany as a model for how to create and identify what is new and incorporate it into what was already familiar and meaningful, all within the purview of developing a professional field of practice.
Sarah Alford provides a rich, interdisciplinary study of how the fields of design and botanical science came together. Through a framework of material culture, Alford sheds new light on the work of leading botanists, designers and illustrators such as Sarah Drake, John Lindley, Richard Redgrave, Owen Jones and Christopher Dresser. This book reveals how the designation of what design reformers deemed appropriate for the surface decoration of material structures as varied as carpets, jugs, wallpaper, and furniture, was an embrace of botanical science as a source of fantasy and imagination.
Semiotics of the COVID-19 Pandemic
Authors: Barreneche Sebastián Moreno 
Published: October 2024

Focusing on the discursive dimension of the COVID-19 pandemic from a semiotic perspective, this book uses semiotic theory and methods to analyse the meaning-making mechanisms and dynamics that occurred during, and revolved around, the pandemic.
Demonstrating the utility of semiotic theory, concepts and analytical methods to make sense of discursive phenomena like those triggered by the COVID-19 pandemic, the book explores in detail:
· the blame-attribution discourses that emerged at the beginning of the pandemic; · how the coronavirus was brought to life in plastic and visual manifestations as a monster that poses a threat to humans; · how the collective actor ‘the healthcare workers’ was constructed in discourse and axiologised in positive terms; · the semiotics of the body during the pandemic, with a focus on the face, facemasks, social distancing and the uses of the body in online environments; · the idea of a ‘new’ normality following the pandemic.
The book examines different dimensions of the COVID-19 pandemic, including examples from Europe, Latin America and the United States and a wide range of images, texts, practices and objects, in order to highlight the importance of its discursive and semiotic nature.
Encountering Material Culture Through Archaeological Fiction
Authors: Dodd Kerry 
Published: October 2024

Investigating the representation of artefacts, objects and ‘things’ in a range of predominantly Western archaeological fiction from the late Victorian period to the modern day, this book examines the narratives through which humanity represents its own material heritage in relation to notions of enchantment, exhibition, estrangement, adventure, tourism and waste.
Kerry Dodd asserts that comprehending the structures through which material culture is presented within archaeological media reveals the structures that transform an object from rubbish to relic. Calling upon such indicative literature, films, TV series and video games asTomb Raider,Indiana Jones,UnchartedandRelic Hunter, this book explores the depiction of material culture through three principal areas – relics, exhibition and adventure.
Outlining a critical framework of artefact representation, Dodd argues that such iconic moments as Howard Carter’s remark that he saw ‘wonderful things’ when he broke into the antechamber of Tutankhamun’s tomb remain recognisable through the evocation of a spectacular visual, despite little concrete definition of the objects witnessed. This book offers a unique exploration of how such figures as Indiana Jones, Lara Croft and Carter have cemented a cultural recognition of what an artefact constitutes as being dependent on how an object is encountered. It is through the very ‘wonder’ of things that Dodd breaks down the boundaries between popular and professional archaeology by pushing forward critical considerations of material culture.