bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma
Authors: Gibson Christopher J. , Lindsley R. Coleman , Tchekmedyian Vatche , Mar Brenton G. , Shi Jiantao , Jaiswal Siddhartha , Bosworth Alysia , Francisco Liton , He Jianbo , Bansal Anita , Morgan Elizabeth A. , Lacasce Ann S. , Freedman Arnold S. , Fisher David C. , Jacobsen Eric , Armand Philippe , Alyea Edwin P. , Koreth John , Ho Vincent , Soiffer Robert J. , Antin Joseph H. , Ritz Jerome , Nikiforow Sarah , Forman Stephen J. , Michor Franziska , Neuberg Donna , Bhatia Ravi , Bhatia Smita , Ebert Benjamin L. 
Published: February 2017

Purpose Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition characterized by somatic mutations in the blood of otherwise healthy adults. We hypothesized that in patients undergoing autologous stem-cell transplantation (ASCT) for lymphoma, CHIP at the time of ASCT would be associated with an increased risk of myelodysplastic syndrome and acute myeloid leukemia, collectively termed therapy-related myeloid neoplasm (TMN), and other adverse outcomes. Methods We performed whole-exome sequencing on pre- and post-ASCT samples from 12 patients who developed TMN after autologous transplantation for Hodgkin lymphoma or non-Hodgkin lymphoma and targeted sequencing on cryopreserved aliquots of autologous stem-cell products from 401 patients who underwent ASCT for non-Hodgkin lymphoma between 2003 and 2010. We assessed the effect of CHIP at the time of ASCT on subsequent outcomes, including TMN, cause-specific mortality, and overall survival. Results For six of 12 patients in the exome sequencing cohort, mutations found in the TMN specimen were also detectable in the pre-ASCT specimen. In the targeted sequencing cohort, 120 patients (29.9%) had CHIP at the time of ASCT, which was associated with an increased rate of TMN (10-year cumulative incidence, 14.1% v 4.3% for those with and without CHIP, respectively; P = .002). Patients with CHIP had significantly inferior overall survival compared with those without CHIP (10-year overall survival, 30.4% v 60.9%, respectively; P < .001), including increased risk of death from TMN and cardiovascular disease. Conclusion In patients undergoing ASCT for lymphoma, CHIP at the time of transplantation is associated with inferior survival and increased risk of TMN.
Pediatric Hodgkin Lymphoma Treated at Cancer Institute, Chennai, India: Long-Term Outcome
Authors: Radhakrishnan Venkatraman , Dhanushkodi Manikandan , Ganesan Trivadi S. , Ganesan Prasanth , Sundersingh Shirley , Selvaluxmy Ganesarajah , Swaminathan Rajaraman , Rama Ranganathan , Sagar Tenali Gnana 
Published: February 2017

Purpose Pediatric Hodgkin lymphoma (HL) is a highly curable malignancy. Outcomes for pediatric HL may vary between developed and developing countries for multiple reasons. This study was conducted to ascertain the outcomes of children with HL at our center and to identify risk factors for recurrent disease. Methods We analyzed the outcomes of 172 consecutive, previously untreated patients with pediatric HL presenting at our center from 2001 to 2010. Patients were treated with either adriamycin, bleomycin, vinblastine, and dacarbazine or adriamycin, bleomycin, vinblastine, cyclophosphamide, vincristine, prednisone, and procarbazine chemotherapy initially, and radiation to bulky sites or a single site of residual disease when appropriate. Results The median duration of follow-up was 77 months. The median age of the patients was 10 years; 127 (74%) of the 172 patients were male. The extent of disease was stage I and II in 59% of the patients. B symptoms were present in 32% of the patients, and 27% had bulky disease. The most common histologic subtype was mixed cellularity (45%). The 5-year overall survival (OS) and progression-free survival (PFS) of the entire cohort were 92.9% and 83.1%, respectively. The 5-year OS rates for patients with stage I, II, III, and IV were 96%, 94.7%, 84%, and 69.8%, respectively. On univariate analysis, advanced stage, response on interim radiologic assessment, and presence of B symptoms significantly predicted inferior PFS and OS. On multivariate analysis, only interim radiologic response significantly predicted PFS ( P < .001) and OS ( P < .001). Conclusion Overall, the outcomes of patients treated at our center are comparable to those observed in other centers in India and globally.
Clinical Overestimation of HER2 Positivity in Early Estrogen and Progesterone Receptor–Positive Breast Cancer and the Value of Molecular Subtyping Using BluePrint
Authors: Myburgh Ettienne J. , Langenhoven Lizanne , Grant Kathleen A. , van der Merwe Lize , Kotze Maritha J. 
Published: February 2017

Purpose Human epidermal growth factor receptor 2 (HER2) positivity is an important prognostic and predictive indicator in breast cancer. HER2 status is determined by immunohistochemistry and fluorescent in situ hybridization (FISH), which are potentially inaccurate techniques as a result of several technical factors, polysomy of chromosome 17, and amplification or overexpression of CEP17 (centromeric probe for chromosome 17) and/or HER2. In South Africa, HER2-positive tumors are excluded from a MammaPrint (MP; Agendia BV, Amsterdam, Netherlands) pretest algorithm. Clinical HER2 status has been reported to correlate poorly with molecular subtype. The aim of this study was to investigate the correlation of clinical HER2 status with BluePrint (BP) molecular subtyping. Methods Clinico-pathologic and genomic information was extracted from a prospectively collected central MP database containing records of 256 estrogen receptor–positive and/or progesterone receptor–positive tumors. Twenty-one tumors considered HER2 positive on immunohistochemistry or FISH were identified for this study. Results The median age of patients was 56 years (range, 34 to 77 years), with a median tumor size of 16 mm (3 to 27 mm). Four (19%) tumors were confirmed HER2-enriched subtype, six (29%) were luminal A, and 11 (52%) were luminal B. The positive predictive values of HER2/CEP17 ratio ≥ 2 and HER2 copy number ≥ 6 were only 29% and 40%, respectively. The differences in means for HER2/CEP17 ratio were significant between BP HER2-enriched versus luminal ( P = .0249; 95% CI, 0.12 to 1.21) and MP high-risk versus low-risk tumors ( P = .0002; 95% CI, 0.40 to 1.06). Conclusion Of the 21 tumors considered clinically HER2 positive, only four were HER2-enriched subtype with BP, indicating an overestimation of HER2 positivity. FISH testing has a poor positive predictive value.
Allogeneic Stem Cell Transplant for Acute Myeloid Leukemia: Evolution of an Effective Strategy in India
Authors: Ganapule Abhijeet , Nemani Sandeep , Korula Anu , Lakshmi Kavitha M. , Abraham Aby , Srivastava Alok , Balasubramanian Poonkuzhali , George Biju , Mathews Vikram 
Published: February 2017

Purpose There are limited data from developing countries on the role and cost-effectiveness of allogeneic stem cell transplantation (allo-SCT) for patients with acute myeloid leukemia (AML). Patients and Methods We undertook a retrospective descriptive study of all patients with AML who underwent allo-SCT from 1994 to 2013 at our center to evaluate the clinical outcomes and cost-effectiveness of this therapeutic modality. Results Two hundred fifty-four consecutive patients, median age 34 years, who underwent allo-SCT at our center were included in this study. There were 161 males (63.4%). The 5-year overall survival (OS) and event-free survival for the entire cohort was 40.1 ± 3.5% and 38.7 ± 3.4%, respectively. The 5-year OS for patients in first (CR1), second, and third complete remission and with disease/refractory AML was 53.1 ± 5.2%, 48.2 ± 8.3%, 31.2 ± 17.8%, and 16.0 ± 4.4%, respectively ( P < .001). From 2007, reduced intensity conditioning (RIC) with fludarabine and melphalan (Flu/Mel) was used in a majority of patients in CR1 (n = 67). Clinical outcomes were compared with historical conventional myeloablative conditioning regimens (n = 38). Use of Flu/Mel was associated with lower treatment-related mortality at 1 year, higher incidence of chronic graft-versus-host-disease, and comparable relapse rates. The 5-year OS and event-free survival for Flu/Mel and myeloablative conditioning group was 67.2 ± 6.6% versus 38.1 ± 8.1% ( P = .003) and 63.8 ± 6.4% versus 32.3 ± 7.9% ( P = .002), respectively. Preliminary cost analysis suggests that in our medical cost payment system, RIC allo-SCT in CR1 was likely the most cost-effective strategy in the management of AML. Conclusion In a resource-constrained environment, Flu/Mel RIC allo-SCT for AML CR1 is likely the most efficacious and cost-effective approach in a subset of newly diagnosed young adult patients.
Impact of Reflex EGFR/ALK Testing on Time to Treatment of Patients With Advanced Nonsquamous Non–Small-Cell Lung Cancer
Authors: Cheema Parneet K. , Menjak Ines B. , Winterton-Perks Zoe , Raphael Simon , Cheng Susanna Y. , Verma Sunil , Muinuddin Ahmad , Freedman Ryan , Toor Nevkeet , Perera Joseph , Anaka Matthew , Victor J. Charles 
Published: February 2017

Purpose: Optimal first-line systemic therapy for patients with advanced nonsquamous (nonsq) non–small-cell lung cancer (NSCLC) requires confirmation of EGFR/ ALK status, which can delay treatment. We evaluated the impact of reflex testing, defined as pathologists initiating EGFR/ ALK testing at the time of diagnosis of nonsq NSCLC, on time to treatment (TTT). Methods: We conducted a retrospective review of patients with nonsq NSCLC with medical oncology consultation at Sunnybrook Odette Cancer Centre between March 18, 2010 and April 30, 2014. Data were compared during routine and reflex testing. TTT was defined as the interval between the first medical oncology visit with advanced NSCLC and the initiation of systemic therapy. Results: A total of 306 patients were included (n = 232 for routine testing, n = 74 for reflex testing). There was a trend to improvement in median TTT with reflex testing (36 days [interquartile range {IQR}, 16 to 71 days v 26 days [IQR, 8 to 41 days], P = .071). Omitting patients with intentional delays in systemic therapy for low-volume disease, poor performance status, comorbidity management, and/or radiation therapy, median TTT improved (34 days [IQR, 15 to 67 days] v 22 days [IQR, 8 to 42 days], P = .049). Time to optimal first-line systemic therapy according to published guidelines improved (median, 36 days [IQR, 16 to 91 days] v 24 days [IQR, 8 to 43 days], P = .036). There was no impact on receipt of any first-line systemic therapy (55% v 59%, P = .66). The quality of biomarker testing improved, with fewer unsuccessful tests ( EGFR, 14% v 4%, P = .039; and ALK, 17% v 3%, P = .037). Conclusion: Reflex testing of EGFR/ ALK improved the time to optimal systemic therapy and the quality of biomarker testing for patients with advanced nonsq NSCLC.
Redesigning Cancer Care Delivery: Views From Patients and Caregivers
Authors: Patel Manali I. , Periyakoil Vyjeyanthi S. , Blayney Douglas W. , Moore David , Nevedal Andrea , Asch Steven , Milstein Arnold , Coker Tumaini R. 
Published: February 2017

Introduction:Cancer is a leading cause of death in the United States. Although treatments have improved, patients and caregivers continue to report significant gaps in their care. The objective of this study was to examine the views of patients and caregivers on their experiences with current cancer care delivery and identify key strategies to improve the delivery of care.Methods and Materials:Semistructured interviews were conducted with 75 patients and 45 caregivers across the United States. The interviews were recorded, transcribed, and analyzed using constant comparative method of qualitative analysis.Results:Participants reported multiple gaps in care delivery, including barriers in health communication with health care providers, lack of elucidation of care goals, lack of care coordination, and challenges in accessing care. Participants identified that greater use of nonphysician providers and alternative formats, such as telephone-based care and home and community-based care, would narrow these gaps.Conclusion:Understanding patients’ and caregivers’ experiences with gaps in cancer care delivery can inform cancer care delivery redesign efforts and lead to targeted interventions that result in patient-centered and family-oriented care.
Hospice Utilization and Its Effect on Acute Care Needs at the End of Life in Medicare Beneficiaries With Hepatocellular Carcinoma
Authors: Sanoff Hanna K. , Chang YunKyung , Reimers Melissa , Lund Jennifer L. 
Published: February 2017

Introduction: Hepatocellular carcinoma (HCC) is a poor-prognosis cancer with a high symptom burden. Multidisciplinary HCC care is complex and unique in cancer medicine. We sought to determine whether the distinct process affects hospice use and how hospice affects end-of-life acute care utilization. Patients and Methods: Patients dying after HCC diagnosed from 2004 to 2011 were identified within SEER-Medicare. Hospice use and associated factors were described using logistic regression. Coarse exact and propensity score matching created groups of hospice and nonhospice comparators balanced on clinical characteristics. Health care use from first hospice claim to death and the matched duration in the nonhospice group were compared. Results: Of 7,992 decedent patients with HCC, 63% used hospice before death, with a median duration of 18 days (interquartile range, 5-51 days). Initial treatment with surgery and ablation (odds ratio [OR], 0.63; 95% CI, 0.53 to 0.74) or chemoembolization/radioembolization (OR, 0.71; 95% CI, 0.62 to 0.80) was associated with decreased odds of subsequent hospice use compared with untreated patients. Hospice use was more likely in those consulting hematology/oncology (OR, 1.33; 95% CI, 1.13 to 1.56) but not in those consulting gastroenterology (OR, 0.79; 95% CI, 0.65 to 0.95). Hospice patients had lower rates of hospitalization (7.9% v 47.8%; risk ratio [RR], 0.16; 95% CI, 0.14 to 0.19), intensive care unit stay (2.8% v 25.3%; RR, 0.11; 95% CI, 0.09 to 0.14), and in-hospital death (3.5% v 58.4%; RR, 0.06; 95% CI, 0.05 to 0.07). Conclusion: Processes of care influence which patients with HCC are referred to hospice. Hospice use has a marked effect on acute care use at the end of life in patients with HCC. Efforts to incorporate cancer-focused palliative care might improve the quality of end-of-life care in HCC.
The influence of placements on adult nursing graduates' choice of first post
Authors: Wareing Mark , Taylor Renate , Wilson Aileen , Sharples Adrienne 
Published: February 2017

Background: This article presents findings from a study that sought to explore the extent to which clinical placements have an impact on nursing students' decisions regarding their first staff nurse post. Within the UK, nursing is facing a recruitment crisis with particular difficulty recruiting to areas such as primary care and care of older people. Transitioning into a new role is challenging in any occupation, but it is a particular problem in nursing where the realities of professional practice often differ from students' perception of the staff nurse role as shaped by their clinical placements. Aim: This pilot study aimed to explore the influence of practice placements on final-year adult nursing students' career decisions. Method: Qualitative and quantitative data were collected in a single phase using a questionnaire distributed to nursing students on the final day of their course. A total of 35 completed questionnaires were returned (response rate 57%). Results: Half of the participants entered the course with preconceived preferences for clinical specialisms. However, only five participants (14%) applied for first-destination posts in that specialism. The overall importance of placements in career choice increased across the three years of the programme. Although placements in all three years are important, the experiences in year 3 are pivotal, with 74% ranking these as ‘significantly influential’ in their decision-making process. Analysis of the data obtained from the free-text responses from the questionnaire suggested that working environment; the level of support provided by mentors and clinical staff; the opportunity to make a difference to patients' lives and the variety of placements, were key influences on nursing students' decision regarding their first staff nurse post. Conclusions: This study highlights the key role of practice placements in the career choices of student nurses, particularly during the final year of their programme. It shows that students are likely to apply for posts in the placement area they found to be most supportive and developmental.
Nursing children and young people: what mental health training is required?
Authors: Thomas Leah 
Published: February 2017

Aim: The aim of this research was to investigate the views of children and young people's nurses on the mental health training they had received and what recommendations they would make for future staff training. Method: Nine such nurses who had experience of nursing young people following self-harm or a suicide attempt were recruited. Data were collected using individual 45-minute semi-structured interviews and analysed using interpretative phenomenological analysis. Results: The findings of this study indicate that children and young people's nurses may benefit from some empathy and attitudes-based training. Participants clearly indicated that they do not feel that they have adequate expertise in mental health nursing. Participants requested training on a variety of mental health topics. Conclusion: The results indicate that children and young people's nurses feel that their current mental health training is inadequate. Individualised training packages for different work areas could be delivered collaboratively by Child and Adolescent Mental Health Services (CAMHS) and specialist children and young people's nurses, using face-to-face teaching methods.
Ficción y reflexión del Pop Art: Mi filosofía de la A a la B y de la B a la A de Andy Warhol
Authors: Capalbo Armando , Pozner Adriana 
Published: February 2017

En Mi filosofía de la A a la B y de la B a la A Warhol resucita la vieja tensión entre arte y vida al preguntarse una y otra vez acerca de la esteticidad de lo real y lo admonitorio de lo trivial. Su filosofía implica trazar una impronta de la realidad y un documento de lo verdadero, ambos interferidos por el crudo paso del tiempo, de la moda y del valor estético. En el libro se entronca la disquisición sobre el lenguaje del arte en el presente. Aunque el tiempo del pop haya desaparecido, la esencia de este escrito es la pregunta de cómo sobrevivir aceptando que la felicidad se ha simplificado y buscar la identificación entre existencia y consumo.
„Nic dobrego”? Kilka uwag o próbach prozatorskich Zdzisława Beksińskiego
Authors: Chomiszczak Tomasz 
Published: February 2017

The article concerns with still not well-known part of the artistic work of Zdzisław Beksiński (a famous photographer, painter and graphic designer). In the 1960s the artist was occupied with literature as well. He wrote short prose which reflected many modern literary fashions and trends, and even anticipated some of them. In his literary works Beksiński was especially influenced by the suggestive aesthetics of the onirism, geometric architecture, and anti-Utopian novels. Sometimes, his narration refers to modern pop culture: the technique of film or the convention of comic strips; what is more, he applies the style of commercials and propaganda slogans. The artist from Sanok also adored writing different variations of the same story which let him play with various genres and plots. But, whatever he did, it was all about the construction, the form. His literary texts record their narrator’s consciousness in a minimalist way, without any traditional literary frills. Therefore Beksiński unconsciously realized the idea postulated at the same time by Cortazar: each prose work should not be a “sum”, but rather a kind of “difference”. This prose substantially complements our knowledge of the whole art of Beksiński, a natural genius, and remains another alternative part of his creative activities.
Motyw obcego w Podróży ósmej Stanisława Lema
Authors: Düring Michael 
Published: February 2017

The article contains a reconstruction of the theme of the alien in The Star Diaries by Stanisław Lem, with special emphasis on The Eighth Voyage. The Author treats this theme as a starting point for existential considerations, and - by reference to the work of Bernard Waldenfels - also for cultural and civilizational considerations.
Focal adhesion stabilization by enhanced integrin-cRGD binding affinity
Authors: Pallarola Diego , Platzman Ilia , Bochen Alexander , Cavalcanti-Adam Elisabetta A. , Axmann Markus , Kessler Horst , Geiger Benjamin , Spatz Joachim P. 
Published: February 2017

AbstractIn this study we investigate the impact of ligand presentation by various molecular spacers on integrin-based focal adhesion formation. Gold nanoparticles (AuNPs) arranged in hexagonal patterns were biofunctionalized with the same ligand head group, cyclic Arg-Gly-Asp [
Unit Root Properties of Seasonal Adjustment and Related Filters: Special Cases
Authors: Bell William.R. 
Published: February 2017

Abstract
Bell (2012) catalogued unit root factors contained in linear filters used in seasonal adjustment (model-based or from the X-11 method) but noted that, for model-based seasonal adjustment, special cases could arise where filters could contain more unit root factors than was indicated by the general results. This article reviews some special cases that occur with canonical ARIMA model based adjustment in which, with some commonly used ARIMA models, the symmetric seasonal filters contain two extra nonseasonal differences (i.e., they include an extra (1 - B)(1 - F)). This increases by two the degree of polynomials in time that are annihilated by the seasonal filter and reproduced by the seasonal adjustment filter. Other results for canonical ARIMA adjustment that are reported in Bell (2012), including properties of the trend and irregular filters, and properties of the asymmetric and finite filters, are unaltered in these special cases. Special cases for seasonal adjustment with structural ARIMA component models are also briefly discussed.
Effects of Scale Direction on Response Style of Ordinal Rating Scales
Authors: Liu Mingnan , Keusch Florian 
Published: February 2017

Abstract
Although ordinal rating scales have received much research attention in survey methodology literature, the direction of the rating scales has not been as extensively studied as other design features. Research on scale direction effect has mainly focused on the influence on response distribution, while largely overlooking its impact on latent constructs. This study examines the scale direction effect on extreme and acquiescent response style latent class variables in an experiment embedded in a national probability sample. We found a higher level of acquiescent response style from scales starting with positive adjective words using a web survey. No significant effect of scale direction was detected on extreme response style or in a face-to-face survey (with show cards). This study also demonstrates that scale direction does not affect the substance latent class variables, once the response style latent class variables are included in the model. Implications of these findings and future research directions are discussed.