bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individual Talker and Token Covariation in the Production of Multiple Cues to Stop Voicing
Authors: Clayards Meghan 
Published: June 2017

Abstract
Background/Aims: Previous research found that individual talkers have consistent differences in the production of segments impacting the perception of their speech by others. Speakers also produce multiple acoustic-phonetic cues to phonological contrasts. Less is known about how multiple cues covary within a phonetic category and across talkers. We examined differences in individual talkers across cues and whether token-by-token variability is a result of intrinsic factors or speaking style by examining within-category correlations. Methods: We examined correlations for 3 cues (voice onset time, VOT, talker-relative onset fundamental frequency, f0, and talker-relative following vowel duration) to word-initial labial stop voicing in English. Results: VOT for /b/ and /p/ productions and onset f0 for /b/ productions varied significantly by talker. Token-by-token within-category variation was largely limited to speaking rate effects. VOT and f0 were negatively correlated within category for /b/ productions after controlling for speaking rate and talker mean f0, but in the opposite direction expected for an intrinsic effect. Within-category talker means were correlated across VOT and vowel duration for /p/ productions. Some talkers produced more prototypical values than others, indicating systematic talker differences. Conclusion: Relationships between cues are mediated more by categories and talkers than by intrinsic physiological relationships.Talker differences reflect systematic speaking style differences.
Interactive Prosodic Marking of Focus, Boundary and Newness in Mandarin
Authors: Wang Bei , Xu Yi , Ding Qifan 
Published: June 2017

AbstractThe current study investigates whether and how focus, phrase boundary and newness can be simultaneously marked in speech prosody in Mandarin Chinese. Homophones were used to construct three syntactic structures that differed only in boundary condition, focus was elicited by preceding questions, while newness of postboundary words was manipulated as whether they had occurred in the previous text. Systematic analysis of F0 and duration showed that (1) duration was a reliable correlate of boundary strength regardless of focus location, while involvement of F0 was only in terms of lowering of phrase-final F0 minima and raising of phrase-initial F0 minima at a relatively strong boundary, (2) postfocus compression (PFC) of F0 was applied across all boundaries, including those with long silent pauses (over 200 ms), and postfocus F0 was lowered to almost the same degree in all boundary conditions, and (3) newness of postfocus words had no systematic effect on F0 or duration. These results indicate that not only functionally focus is independent of prosodic structure and newness, but also phonetically its realization is separate from boundary marking. Focus is signaled mainly through pitch range adjustments, which can occur even across phrase breaks, whereas boundaries are mostly signaled by duration adjustments.
Antithrombotic therapy for acute coronary syndrome: Past, present and future
Authors: Sibbing Dirk , Angiolillo Dominick J. , Huber Kurt 
Published: June 2017

SummaryPlaque erosions and ruptures are the histopathological hallmarks of arterial thrombus formation in the coronary arteries. The clinical condition associated with this process is usually referred to as acute coronary syndrome (ACS). Importantly, both blood platelets and the coagulation cascade are key players for initiation, amplification and perpetuation of ACS. There has been great progress in ACS treatment in recent decades, both at the technical level of (percutaneous) revascularisation and at the level of antithrombotic treatment. Numerous trials have led to significant advancements in the development of effective anticoagulant and antiplatelet drugs. The large number of randomised controlled clinical trials (RCTs) and the huge number of patients enrolled in these RCTs, with mega trials including >10,000 patients, is unique in the history of medical research and also reflects the exceptional efforts associated with these huge research activities. The crucial issue, however, with respect to optimising treatment, relates to finding the delicate balance between the reduction of thrombotic events by effective drug treatment and the induction of bleeding that is linked to the use of potent or multiple antithrombotic agents. Interestingly, there is a gap in modern days between current guideline recommendations favouring potent platelet inhibition in ACS and the utilization of the respective drugs in clinical practice. In this review, we will summarise and discuss the past, present and future antithrombotic treatment for ACS patients with a focus on the development of optimised antiplatelet treatment strategies and their utilisation in the real world.
Late Systolic Myocardial Loading Is Associated With Left Atrial Dysfunction in Hypertension
Authors: Chirinos Julio A. , Phan Timothy S. , Syed Amer A. , Hashmath Zeba , Oldland Harry G. , Koppula Maheswara R. , Tariq Ali , Javaid Khuzaima , Miller Rachana , Varakantam Swapna , Dunde Anjaneyulu , Neetha Vadde , Akers Scott R. 
Published: June 2017

Background—
Late systolic load has been shown to cause diastolic dysfunction in animal models. Although the systolic loading sequence of the ventricular myocardium likely affects its coupling with the left atrium (LA), this issue has not been investigated in humans. We aimed to assess the relationship between the myocardial loading sequence and LA function in human hypertension.

Methods and Results—
We studied 260 subjects with hypertension and 19 normotensive age- and sex-matched controls. Time-resolved central pressure and left ventricular geometry were measured with carotid tonometry and cardiac magnetic resonance imaging, respectively, for computation of time-resolved ejection-phase myocardial wall stress (MWS). The ratio of late/early ejection-phase MWS time integrals was computed as an index of late systolic myocardial load. Atrial mechanics were measured with cine-steady-state free-precession magnetic resonance imaging using feature-tracking algorithms. Compared with normotensive controls, hypertensive participants demonstrated increased late/early ejection-phase MWS and reduced LA function. Greater levels of late/early ejection-phase MWS were associated with reduced LA conduit, reservoir, and booster pump LA function. In models that included early and late ejection-phase MWS as independent correlates of LA function, late systolic MWS was associated with lower, whereas early systolic MWS was associated with greater LA function, indicating an effect of the relative loading sequence (late versus early MWS) on LA function. These relationships persisted after adjustment for multiple potential confounders.

Conclusions—
A myocardial loading sequence characterized by prominent late systolic MWS was independently associated with atrial dysfunction. In the context of available experimental data, our findings support the deleterious effects of late systolic loading on ventricular–atrial coupling.
In Situ Quantification of the Suspended Load of Estuarine Aggregates from Multifrequency Acoustic Inversions
Authors: Fromant G. , Floc’h F. , Lebourges-Dhaussy A. , Jourdin F. , Perrot Y. , Le Dantec N. , Delacourt C. 
Published: June 2017

AbstractThe study of the suspended particulate matter (SPM) transport is essential to understanding oceans and rivers, for their presence can impact the environment, from marine habitats or water quality degradations to important changes of the seabed morphology. Among a large number of surrogate techniques in traditional water sampling, acoustical methods have the advantage of providing nonintrusive measurements, with high spatial and temporal resolutions. However, the ability of fine-grained sediments to aggregate under the process of flocculation complexifies the interpretation of acoustical measurements. The objective of this paper is to design a simple backscattering model for flocculated sediment suspensions, in order to interpret the information provided by a multifrequency profiler and to retrieve both the concentration and the dominant size of a suspension of flocculated sediments in an estuarine context. In situ granulometry laser data, collected in the Aulne macrotidal estuary (France), showed that over the size distribution observed, a mean porosity of apparent particles in suspension can be used directly as input for model generation. The in situ acoustic signal was concurrently recorded at 0.5, 1, 2, and 4 MHz, and then inverted using the nonnegative least squares algorithm after constraining the model with an optimal porosity, allowing for a discrete representation of the mass concentration distributed over several equivalent spherical radii. The inversion results are in good agreement with the in situ mass concentration obtained through in situ water samplings.
Reversible drug-induced antiphospholipid syndrome
Authors: Risse J , Vieira M , Beuret F , Petitpain N , Zuily S , Wahl D 
Published: June 2017

We report an original case of reversible antiphospholipid syndrome (APS) due to minocycline in a young male patient who experienced recurrent strokes while taking minocycline. He started minocycline therapy (50 mg twice daily) at 15 years old for acne. After three years of treatment, the patient experienced a lateral medullary syndrome. He was treated with aspirin while minocycline was continued. Eighteen months later, the patient complained about horizontal binocular diplopia. MRI revealed an infarct of the oculomotor nerve nucleus. Laboratory investigations revealed high titers of anti-beta 2 glycoprotein 1 (antiβ2GP1) antibodies of 470 U/ml (normal range <15 U/ml) and antiphosphatidylethanolamine antibodies of 137.4 U/ml (normal range <18 U/ml). Other laboratory tests were normal. Six weeks after discontinuation of minocycline, anti-β2GP1 antibodies decreased to 335 U/ml and to 36 U/ml at six months and then remained negative for six years. Many drugs have been considered as possibly causing APS but only in a limited number of patients. To our knowledge this is the first case of drug-induced APS with complete disappearance of high titers of anti-β2GP1 antibodies after minocycline withdrawal. This case also illustrates the need to monitor the levels of antiphospholipid antibodies, even though initial values are high and confirmed after 12 weeks.
Feline leprosy due to Mycobacterium lepraemurium: Further clinical and molecular characterisation of 23 previously reported cases and an additional 42 cases
Authors: O’Brien Carolyn R , Malik Richard , Globan Maria , Reppas George , McCowan Christina , Fyfe Janet A 
Published: June 2017

Objectives: This paper, the second in a series of three on ‘feline leprosy’, provides a detailed description of disease referable to Mycobacterium lepraemurium, the most common cause of feline leprosy worldwide. Methods: Cases were sourced retrospectively and prospectively for this observational study, describing clinical, geographical and molecular microbiological data for cats definitively diagnosed with M lepraemurium infection. Results: A total of 145 cases of feline leprosy were scrutinised; 114 ‘new’ cases were sourced from the Victorian Infectious Diseases Reference Laboratory records, veterinary pathology laboratories or veterinarians, and 31 cases were derived from six published studies. Sixty-five cats were definitively diagnosed with M lepraemurium infection. Typically, cats were 1–3 years of age when first infected, with a male gender predilection. Affected cats were generally systemically well. All had outdoor access. Lesions tended to consist of one or more cutaneous/subcutaneous nodules, typically located on the head and/or forelimbs, possibly reflecting the most likely locations for a rodent bite as the site of inoculation for organisms. Nodules had the propensity to ulcerate at some stage in the clinical course. The cytological and histological picture varied from tuberculoid, with relatively low bacterial numbers, to lepromatous with moderate to high bacterial numbers. Treatment was varied, although most cats underwent surgical resection of lesions with adjunctive medical therapy, most often using a combination of oral clarithromycin and rifampicin. Prognosis for recovery was generally good, and in two cases there was spontaneous remission without the requirement for medical intervention. Untreated cats continued to enjoy an acceptable quality of life despite persistence of the disease, which extended locally but had no apparent tendency to disseminate to internal organs. Conclusions and relevance: M lepraemurium causes high bacterial index (lepromatous) or low bacterial index (tuberculoid) feline leprosy. The infection typically causes nodules of the skin and/or subcutis (which tend towards ulceration) on the head and/or forelimbs. The disease usually has an indolent clinical course and infected cats have a generally favourable response to therapeutic interventions, with rare cases undergoing spontaneous resolution. Genomic analysis may yield clues as to the environmental niche and culture requirements of this elusive organism. Prospective treatment trials and/or additional drug susceptibility testing in specialised systems would further inform treatment recommendations.
Integrating Research and Practice: Looking Back
Authors: Wang Jia 
Published: June 2017

The Problem The divide between research and practice has long been recognized by both scholars and practitioners in multiple applied fields, including our field of human resource development (HRD). Significant amount of energy has been devoted to identify ways to bridge the gap, yet the divide has remained noticeably wide. Developing scholar-practitioners is considered a viable solution, yet how to prepare them is not quite so clear. The Solution This issue provides an actionable plan by drawing upon the firsthand experiences and real-life examples from those who have successfully crossed the two worlds. By focusing on the how-to, this issue provides a tool box for multiple parties. The Stakeholders Three groups of stakeholders will benefit directly from this issue, scholar-practitioners, practitioners seeking scholarly practice, and scholars desiring to ground their research in practice. This issue will also benefit organizations, intermediaries, and HRD as an applied field.
Renal dysfunction indicative of outcomes in hospitalized patients with takotsubo syndrome
Authors: Ando Kaoru , Sukekawa Hiroyasu , Takahata Aoi , Kobari Yusuke , Tsuchiya Hayato , Ishigaki Daisuke , Tamabuchi Toshiaki , Koyama Yo 
Published: June 2017

Background: Left ventricular dysfunction as part of takotsubo syndrome is reversible, and the long-term prognosis appears favorable. However, life-threatening complications are not uncommon during the acute phase, and it remains unclear whether renal dysfunction is a factor in complications suffered by hospitalized patients with takotsubo syndrome. The present study was conducted to investigate the implications of renal dysfunction in this setting. Methods: Data from 61 consecutive patients (male, 21; female, 40) diagnosed with takotsubo syndrome at our hospital between years 2010 and 2016 were evaluated retrospectively. In-hospital complications by definition were all-cause deaths and severe pump failure (Killip class ≥III). Results: Overall, 30 patients (49%) developed renal dysfunction. In the 32 patients (52%) who suffered in-hospital complications (mortality, 10; severe pump failure, 22), estimated glomerular filtration rate (eGFR) was significantly lower by comparison (51.3±29.8 vs. 69.5±29.0; p=0.019). Low eGFR (<30 ml/min per 1.73m2) proved independently predictive of in-hospital complications (hazard ratio =2.84, 95% confidence interval: 1.20–6.69) in multivariate Cox hazard analysis, also showing a significant association with peak event rate of Kaplan–Meier curve (log-rank test, p=0.0073). Similarly, patients with chronic kidney disease were at significantly greater risk of in-hospital complications (hazard ratio=2.49, 95% confidence interval: 1.01–5.98), relative to non-compromised counterparts (eGFR >60 ml/min per 1.73m2). Conclusion: Renal dysfunction is a simple but useful means of predicting complications in hospitalized patients with takotsubo syndrome, especially those with chronic kidney disease.
Light sources for high-volume manufacturing EUV lithography: technology, performance, and power scaling
Authors: Fomenkov Igor , Brandt David , Ershov Alex , Schafgans Alexander , Tao Yezheng , Vaschenko Georgiy , Rokitski Slava , Kats Michael , Vargas Michael , Purvis Michael , Rafac Rob , La Fontaine Bruno , De Dea Silvia , LaForge Andrew , Stewart Jayson , Chang Steven , Graham Matthew , Riggs Daniel , Taylor Ted , Abraham Mathew , Brown Daniel 
Published: June 2017

Abstract
Extreme ultraviolet (EUV) lithography is expected to succeed in 193-nm immersion multi-patterning technology for sub-10-nm critical layer patterning. In order to be successful, EUV lithography has to demonstrate that it can satisfy the industry requirements in the following critical areas: power, dose stability, etendue, spectral content, and lifetime. Currently, development of second-generation laser-produced plasma (LPP) light sources for the ASML’s NXE:3300B EUV scanner is complete, and first units are installed and operational at chipmaker customers. We describe different aspects and performance characteristics of the sources, dose stability results, power scaling, and availability data for EUV sources and also report new development results.
Classification of pulmonary pathology from breath sounds using the wavelet packet transform and an extreme learning machine
Authors: Palaniappan Rajkumar , Sundaraj Kenneth , Sundaraj Sebastian , Huliraj N. , Revadi S.S. 
Published: June 2017

Abstract

Background:
Auscultation is a medical procedure used for the initial diagnosis and assessment of lung and heart diseases. From this perspective, we propose assessing the performance of the extreme learning machine (ELM) classifiers for the diagnosis of pulmonary pathology using breath sounds.

Methods:
Energy and entropy features were extracted from the breath sound using the wavelet packet transform. The statistical significance of the extracted features was evaluated by one-way analysis of variance (ANOVA). The extracted features were inputted into the ELM classifier.

Results:
The maximum classification accuracies obtained for the conventional validation (CV) of the energy and entropy features were 97.36% and 98.37%, respectively, whereas the accuracies obtained for the cross validation (CRV) of the energy and entropy features were 96.80% and 97.91%, respectively. In addition, maximum classification accuracies of 98.25% and 99.25% were obtained for the CV and CRV of the ensemble features, respectively.

Conclusion:
The results indicate that the classification accuracy obtained with the ensemble features was higher than those obtained with the energy and entropy features.
Improving potato cultivation using siphons for partial root-zone drying irrigation: A case study in the Blue Nile river basin, Ethiopia
Authors: Yactayo Wendy , Ramírez David A. , German Tigist , Worku Alemu , Abeb Atklte , Harahagazwe Dieudonné , Mares Victor , De Mendiburu Felipe , Quiroz Roberto 
Published: June 2017

Abstract
Partial root-zone drying (PRD) is an irrigation technique which consists of alternating the water supply from one furrow to another, and keeping the other one dry during the weekly alternation period. Studies assessing PRD in potato have reported a 30-50% of water savings with no tuber yield reductions and an increase of antioxidant concentrations and marketable tubers. In this study, we adapted the PRD technique to rural Ethiopian conditions and compared it against the customary (C) irrigation practiced by local farmers. Two PRD alternatives were evaluated; with (PRDs) and without (PRDw) locally made flexible-hose siphons. Only PRDs showed no significant differences in total (35.8±1.6 t ha-1) and marketable (34.2±1.6 t ha-1) tuber yield when compared with customary irrigation (39.4±1.3 and 37.6±1.2 t ha-1 corresponding to total and marketable yield, respectively). The PRDw was more water restricted, showing significantly lower total (29.7±1.1 t ha-1) and marketable (27.6±1.2 t ha-1) yields. PRDs had the benefit of a better control of applied water allowing a saving of 50% of the irrigation water without negatively affecting yield. The use of the siphons PRD technique provides options for saving scarce water and reaching out to many smallholder farmers who are in serious need of irrigation water in the Blue Nile river basin.
GdCuMg with ZrNiAl-type structure – an 82.2 K ferromagnet
Authors: Stein Sebastian , Heletta Lukas , Pöttgen Rainer 
Published: June 2017

AbstractGdCuMg has been synthesized by induction-melting of the elements in a sealed niobium ampoule followed by annealing in a muffle furnace. The sample was studied by powder and single crystal X-ray diffraction: ZrNiAl type,P6̅2m(a=749.2(4),c=403.3(1) pm),wR2=0.0242, 315F2values and 15 variables. Temperature dependent magnetic susceptibility measurements have revealed an experimental magnetic moment of 8.54(1) μBper Gd atom. GdCuMg orders ferromagnetically belowTC=82.2(5) K and based on the magnetization isotherms it can be classified as a soft ferromagnet.
Rating of Perceived Exertion as a Method of Volume Autoregulation Within a Periodized Program
Authors: Helms Eric R. , Cross Matt R. , Brown Scott R. , Storey Adam , Cronin John , Zourdos Michael C. 
Published: June 2017

Abstract
Helms, ER, Cross, MR, Brown, SR, Storey, A, Cronin, J, and Zourdos, MC. Rating of perceived exertion as a method of volume autoregulation within a periodized program. J Strength Cond Res 32(6): 1627–1636, 2018—The purpose of this investigation was to observe how a rating of perceived exertion (RPE)-based autoregulation strategy impacted volume performed by powerlifters. Twelve (26 ± 7 years, n = 9 men, n = 3 women) nationally qualified powerlifters performed the back squat, bench press, and deadlift 3x per week on nonconsecutive days in a session order of hypertrophy, power, and then strength; for 3 weeks. Each session subjects performed an initial top set for a prescribed number of repetitions at a target RPE. A second top set was performed if the RPE score was too low, then subsequent back-off sets at a reduced load were performed for the same number of repetitions. When the prescribed RPE was reached or exceeded, sets stopped; known as an “RPE stop.” The percentage load reduction for back-off sets changed weekly: there were 2, 4, or 6% RPE stop reductions from the top set. The order in which RPE stop weeks were performed was counterbalanced among subjects. Weekly combined relative volume load (squat + bench press + deadlift), expressed as sets x repetitions x percentage 1-repetition maximum was different between weeks (p < 0.001): 2% = 74.6 ± 22.3; 4% = 88.4 ± 23.8; 6% = 114.4 ± 33.4. Combined weekly bench press volume (hypertrophy + power + strength) was significantly higher in accordance with load reduction magnitude (2% > 4% > 6%; p ≤ 0.05), combined squat volume was greater in 6 vs. 2% (p ≤ 0.05), and combined deadlift volume was greater in 6 vs. 2% and 4% (p ≤ 0.05). Therefore, it does seem that volume can be effectively autoregulated using RPE stops as a method to dictate number of sets performed.