bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity of automated measurement of left ventricular ejection fraction and volume using the Philips EPIQ system
Authors: Hovnanians Ninel , Win Theresa , Makkiya Mohammed , Zheng Qi , Taub Cynthia 
Published: October 2017

PurposeTo assess the efficiency and reproducibility of automated measurements of left ventricular (LV) volumes and LV ejection fraction (LVEF) in comparison to manually traced biplane Simpson's method.MethodThis is a single‐center prospective study. Apical four‐ and two‐chamber views were acquired in patients in sinus rhythm. Two operators independently measured LV volumes and LVEF using biplane Simpson’s method. In addition, the image analysis software a2DQ on the Philips EPIQ system was applied to automatically assess the LV volumes and LVEF. Time spent on each analysis, using both methods, was documented. Concordance of echocardiographic measures was evaluated using intraclass correlation (ICC) and Bland‐Altman analysis.ResultsManual tracing and automated measurement of LV volumes and LVEF were performed in 184 patients with a mean age of 67.3 ± 17.3 years and BMI 28.0 ± 6.8 kg/m2. ICC and Bland‐Altman analysis showed good agreements between manual and automated methods measuring LVEF, end‐systolic, and end‐diastolic volumes. The average analysis time was significantly less using the automated method than manual tracing (116 vs 217 seconds/patient, P < .0001).ConclusionAutomated measurement using the novel image analysis software a2DQ on the Philips EPIQ system produced accurate, efficient, and reproducible assessment of LV volumes and LVEF compared with manual measurement.
Concealing a shiny facial skin appearance by an Aerogel‐based formula. In vitro and in vivo studies
Authors: Cassin G. , Diridollou S. , Flament F. , Adam A. S. , Pierre P. , Colomb L. , Morancais J. L. , Qiu H. 
Published: October 2017

AbstractObjectiveTo explore, in vitro and in vivo, the potential interest of an Aerogel‐based formula, in concealing a naturally shiny facial skin.MethodsIn vitro, various formulae and ingredients were applied as a thin film onto contrast plates and studied through measuring the shine induced following pump spraying of a mixture of oleic acid and mineral water as a sebum/sweat mix model. In such a test, an Aerogel ingredient led to very positive results. In vivo, two different formulae with various concentrations of Aerogel were randomly tested on half side of the face vs. bare side of Chinese women, under some provocative environmental conditions, known to enhance facial shine. These conditions comprised a normal activity under a hot and highly humid summer time followed – or not – by a hamam session. Both studies included comparative evaluations using a half‐face procedure (treated/untreated or vehicle). In the first case, evaluations were quantitatively carried out, whereas the second one was based on a quantitative self‐evaluations from standardized full‐face photographsResultsIn vitro, the tested Aerogel, incorporated at 1% or 2% concentration in a common O/W cosmetic emulsion, shows an immediate light scattering effect, thereby masking shine. Such effect appears of much higher amplitude than that of two other tested particulate ingredients (Talc and Perlite). A noticeable remanence of anti‐shine effect was confirmed in vivo in extreme conditions. The latter was self‐perceived by all participants in the second study. This result is likely related to the super hydrophobic behaviour of the Aerogel.ConclusionAs cosmetic ingredient, this new Aerogel appears as a highly promising ingredient for concealing the facial skin shine, a source of complaint from many consumers living in hot and humid regions.
Evaluation of electrodeposited Mn‐Co protective coatings on Crofer 22 APU steel
Authors: Molin Sebastian 
Published: October 2017

AbstractInterconnects used in Solid Oxide Cells stacks require protective coatings to lower their parabolic rate constant and block chromium evaporation (on the air side). In this work four different protective coatings on steel are evaluated for their high temperature corrosion resistance and electrical conductivity. A commercial electroplating process was used for the preparation of coatings with different Mn/Co ratios on Crofer 22 APU steel. Oxidation of samples was performed in air at 800°C for 1000 hours. Postmortem analysis of the coated samples was performed by scanning electron microscopy and x‐ray diffractomettry. Based on the results, influence of the Co/Mn ratio on the resulting corrosion properties are discussed. Parabolic rate constant of the coated samples is the lowest for the MnCo sample, whereas electrical resistance is the lowest for the Co sample, which has a corrosion rate similar to the not‐coated alloys.
Blackcurrant pomace from juice processing as partial flour substitute in savoury crackers: dough characteristics and product properties
Authors: Schmidt Carolin , Geweke Insa , Struck Susanne , Zahn Susann , Rohm Harald 
Published: October 2017

SummaryBerry pomace is a by‐product of juice processing that, after drying and milling, may be used as an ingredient in cereal‐based products. This, on the one hand, not only reduces losses of edible raw material components, but also increases the nutritional value of the target food because of its high dietary fibre and bioactive compounds content. By using savoury crackers as model, this study analyses how a partial flour replacement by blackcurrant pomace (levels: 10%, 20% or 30%) affects physical properties of the respective dough (dynamic rheology in simulated baking, extensibility and adhesiveness) and characteristics of the baked product (colour, texture and sensory properties). Pomace addition significantly affected both systems. By considering the high moisture absorption capacity of this material through water level adaptation in formulations and by only substituting gluten‐free flour (which led to a constant gluten content), it is demonstrated that even a flour replacement of up to 30% leads to acceptable products. A restrained protein development was observed in pomace containing dough, leading to a lower extensibility, and to reduced volume increase and lower breaking force after baking. In contrast, dough handling and sensory acceptance were not corrupted by pomace application even though colour of the final product was changed to a great extent.
Recent advances in malignant melanoma
Authors: Atkinson Victoria 
Published: October 2017

AbstractIn Australia, there is a high incidence of melanoma, and until recently, the treatment and median overall survival for advanced metastatic melanoma had not changed in decades. The recognition of BRAF as an important tumour oncogene in melanoma has led to the development of targeted therapies, and in the last few years, we have seen the impact of these therapies, with significant improvement in response rate, duration of disease control and overall survival for patients with BRAF mutation‐positive metastatic melanoma. Concurrently, the science of immunotherapy has evolved beyond the knowledge of the importance of the immune system in cancer, leading to the development of checkpoint inhibitors. The development of checkpoint inhibitors as a tolerable and effective therapy for metastatic melanoma, which has demonstrated improved response rates, duration of control and overall survival for patients, has implications beyond the care of patients with metastatic melanoma as these therapies are being trialled in other malignancies. This article will review the current standard of care and available therapies for metastatic malignant melanoma.
TIPE1 suppresses invasion and migration through down‐regulating Wnt/β‐catenin pathway in gastric cancer
Authors: Liu Wenwen , Chen Ye , Xie Hua , Guo Yongmin , Ren Dandan , Li Yupeng , Jing Xu , Li Dongliang , Wang Xiao , Zhao Miaoqing , Zhu Tianfeng , Wang Ziying , Wei Xinbing , Gao Fei , Wang Xiaojie , Liu Suxia , Zhang Yan , Yi Fan 
Published: October 2017

AbstractEpithelial–mesenchymal transition (EMT) plays an important role in the invasiveness and metastasis of gastric cancer. Therefore, identifying key molecules involved in EMT will provide new therapeutic strategy for treating patients with gastric cancer. TIPE1 is a newly identified member of the TIPE (TNFAIP8) family, and its contributions to progression and metastasis have not been evaluated. In this study, we found that the levels of TIPE1 were significantly reduced and inversely correlated with differentiation status and distant metastasis in primary gastric cancer tissues. We further observed overexpression of TIPE1 in aggressive gastric cancer cell lines decreased their metastatic properties both in vitro and in vivo as demonstrated by markedly inhibiting EMT and metastasis of gastric cancer cells in nude mice. Consistently, gene silencing of TIPE1 in well‐differentiated gastric cancer cell line (AGS) inhibited these processes. Mechanistically, we found that TIPE1‐medicated Wnt/β‐catenin signalling was one of the critical signal transduction pathways that link TIPE1 to EMT inhibition. Importantly, TIPE1 dramatically restrained the expression and activities of MMP2 and MMP9 which are demonstrated to promote tumour progression and are implicated in EMT. Collectively, these findings provide new evidence for a better understanding of the biological activities of TIPE1 in progression and metastasis of gastric cancer and suggest that TIPE1 may be an innovative diagnostic and therapeutic target of gastric cancer.
Racemization at the Asp 58 residue in αA‐crystallin from the lens of high myopic cataract patients
Authors: Zhu Xiang‐jia , Zhang Ke‐ke , He Wen‐wen , Du Yu , Hooi Michelle , Lu Yi 
Published: October 2017

AbstractPost‐translational modifications in lens proteins are key causal factors in cataract. As the most abundant post‐translational modification in the lens, racemization may be closely related to the pathogenesis of cataract. Racemization of αA‐crystallin, a crucial structural and heat shock protein in the human lens, could significantly influence its structure and function. In previous studies, elevated racemization from l‐Asp 58 to d‐isoAsp58 in αA‐crystallin has been found in age‐related cataract (ARC) lenses compared to normal aged human lenses. However, the role of racemization in high myopic cataract (HMC), which is characterized by an early onset of nuclear cataract, remains unknown. In the current study, apparently different from ARC, significantly increased racemization from l‐Asp 58 to d‐Asp 58 in αA‐crystallin was identified in HMC lenses. The average racemization rates for each Asp isoform were calculated in ARC and HMC group. In ARC patients, the conversion of l‐Asp 58 to d‐isoAsp 58, up to 31.89%, accounted for the main proportion in racemization, which was in accordance with the previous studies. However, in HMC lenses, the conversion of l‐Asp 58 to d‐Asp 58, as high as 35.44%, accounted for the largest proportion of racemization in αA‐crystallin. The different trend in the conversion of αA‐crystallin by racemization, especially the elevated level of d‐Asp 58 in HMC lenses, might prompt early cataractogenesis and a possible explanation of distinct phenotypes of cataract in HMC.
Specificity of presenilin‐1‐ and presenilin‐2‐dependent γ‐secretases towards substrate processing
Authors: Stanga Serena , Vrancx Céline , Tasiaux Bernadette , Marinangeli Claudia , Karlström Helena , Kienlen‐Campard Pascal 
Published: October 2017

AbstractThe two presenilin‐1 (PS1) and presenilin‐2 (PS2) homologs are the catalytic core of the γ‐secretase complex, which has a major role in cell fate decision and Alzheimer's disease (AD) progression. Understanding the precise contribution of PS1‐ and PS2‐dependent γ‐secretases to the production of β‐amyloid peptide (Aβ) from amyloid precursor protein (APP) remains an important challenge to design molecules efficiently modulating Aβ release without affecting the processing of other γ‐secretase substrates. To that end, we studied PS1‐ and PS2‐dependent substrate processing in murine cells lacking presenilins (PSs) (PS1KO, PS2KO or PS1‐PS2 double‐KO noted PSdKO) or stably re‐expressing human PS1 or PS2 in an endogenous PS‐null (PSdKO) background. We characterized the processing of APP and Notch on both endogenous and exogenous substrates, and we investigated the effect of pharmacological inhibitors targeting the PSs activity (DAPT and L‐685,458). We found that murine PS1 γ‐secretase plays a predominant role in APP and Notch processing when compared to murine PS2 γ‐secretase. The inhibitors blocked more efficiently murine PS2‐ than murine PS1‐dependent processing. Human PSs, especially human PS1, expression in a PS‐null background efficiently restored APP and Notch processing. Strikingly, and contrary to the results obtained on murine PSs, pharmacological inhibitors appear to preferentially target human PS1‐ than human PS2‐dependent γ‐secretase activity.
Reduction effect of the quantity of radiation exposure and contrast media by image support system in transarterial chemoembolization for the treatment of hepatocellular carcinoma
Authors: Tamai Tsutomu , Taniyama Oki , Oda Kohei , Kasai Ai , Ijyuin Syo , Sakae Haruka , Onishi Hiroka , Tabu Kazuaki , Kumagai Kotaro , Mawatari Seiichi , Moriuchi Akihiro , Uto Hirofumi , Ido Akio 
Published: October 2017

AbstractBackground and AimWe confirmed the clinical utility of a three‐dimensional navigation system during transarterial chemoembolization.MethodsWe evaluated 128 tumors in 91 patients enrolled between May 2015 and August 2016. We evaluated the accuracy of the three‐dimensional navigation imaging system for all tumors. We compared the patients who were able to undergo route detection using three‐dimensional navigation with previously treated patients who underwent transarterial chemoembolization without using three‐dimensional navigation (n = 21). For 38 patients who underwent super‐selective microcatheter insertion after a feeding artery was identified by three‐dimensional navigation, we confirmed the relationship between the tumors and contrasted liver parenchyma and divided the computed tomography hepatic arteriography findings into four grades. Grade 1: an overlap of > 5 mm, grade 2: an overlap between 0 and 5 mm, grade 3: the borders of the tumor within the liver parenchyma but in contact with the edges, and grade 4: a tumor outside the borders of the liver parenchyma.ResultsUsing the three‐dimensional navigation system, we identified a tumor‐feeding artery in 125/128 tumors (97.6%). Furthermore, this system allowed us to significantly reduce the volume of contrast media and the radiation exposure dose in patients undergoing an evaluation. We identified 15 grade 1 tumors (39.5%), 3 grade 2 tumors (7.9%), 11 grade 3 tumors (28.9%), and 9 grade 4 tumors (23.7%) according to our definitions.ConclusionThe three‐dimensional navigation is useful not only for patients but also for surgeons who have relatively little experience.
Potential drug–drug interactions of OMBITASVIR, PARITAPREVIR/ritonavir ± DASABUVIR ± ribavirin in clinical practice
Authors: González‐Colominas Elena , Londoño María‐Carlota , Morillas Rosa M , Torras Xavier , Mojal Sergi , Lens Sabela , López Dulce , Gallego Adolfo , Mariño Zoe , Ardèvol Mercè , Pagès Neus , Solà Ricard , Carrión Jose A 
Published: October 2017

AbstractBackground & AimsDrug–drug interactions (DDIs) with ombitasvir/paritaprevir/ritonavir with or without dasabuvir and with or without ribavirin (OBV/PTV/r ± DSV ± RBV) are common in clinical trials. Our aim was to analyze the prevalence and management of potential DDIs and adverse events (AEs) related to DDIs in patients with chronic hepatitis C (CHC) receiving OBV/PTV/r ± DSV ± RBV in clinical practice.Methods177 CHC patients started OBV/PTV/r ± DSV ± RBV in 4 Spanish hospitals and were screened for potential DDIs using the University of Liverpool database. Patients were classified according to the most serious potential DDIs at baseline and AEs during therapy.ResultsAt least one potential DDI was found in 110 (62.1%) patients: 100 (56.5%) had at least one manageable potential DDI and 10 (5.6%) at least one contraindicated. Patients with potential DDIs were receiving a higher number of concomitant drugs (4 vs. 2, P < 0.001). Routine medication was modified at baseline due to potential DDIs in 49 (27.7%) patients. During antiviral treatment, 67 (37.9%) patients presented at least one AE. In 9 (4.5%) patients, a DDI was suspected between OBV/PTV/r ± DSV ± RBV and the concomitant drug, requiring antiviral discontinuation in 4 patients.ConclusionsPotential DDIs are frequent with OBV/PTV/r ± DSV ± RBV, although a change in baseline medication is made in only one‐quarter of patients. More than half of potential DDIs were only followed, and only 5% of patients developed AEs in which the implication of DDIs could not be excluded.
Clinical significance of small‐bowel villous edema in patients with liver cirrhosis: A capsule endoscopy study
Authors: Otani Ichiro , Oka Shiro , Tanaka Shinji , Tsuboi Akiyoshi , Kunihara Sayoko , Nagaoki Yuko , Aikata Hiroshi , Chayama Kazuaki 
Published: October 2017

AbstractBackground and AimThe relationship between the presence of villous edema (VE) in portal hypertensive enteropathy and clinical factors remains unclear. The aim of this study was to reveal the clinical factors related to VE in patients with liver cirrhosis (LC), and investigate the clinical significance of VE.MethodsBetween February 2009 and September 2016, 363 consecutive patients with LC underwent capsule endoscopy for diagnosing portal hypertensive enteropathy at Hiroshima University Hospital. We evaluated the relationship between the presence of VE and patients' clinical characteristics, findings of esophagogastroduodenoscopy and computed tomography, and survival time.ResultsVillous edema was observed in 131 patients (36%), and severe lesions were found in 71 (20%). The presence of VE was significantly greater in patients with Child–Pugh classification B or C, esophageal varices, portal hypertensive gastropathy (PHG), ascites, portal vein thrombosis (PVT), and splenomegaly. In multivariate analysis, Child–Pugh class B or C, esophageal varices, PVT, and splenomegaly were significant predictive factors for the presence of VE. Severe VE was significantly greater in patients with Child–Pugh class B or C, serum albumin level ≤ 3.2 mg/dL, PHG, and PVT. In multivariate analysis, PHG, Child–Pugh class B or C, PVT, were significant predictive factors for severe VE.ConclusionsClinical factors related to portal hypertension were significantly correlated with VE. In particular PVT was correlated with the appearance and exacerbation of VE. Periodic capsule endoscopy in LC patients may lead to early detection of portal hypertension and PVT.
Functional interleukin‐6 receptor‐α is located in tanycytes at the base of the third ventricle
Authors: Anesten F. , Santos C. , Gidestrand E. , Schéle E. , Pálsdóttir V. , Swedung‐Wettervik T. , Meister B. , Patrycja Skibicka K. , Jansson J.‐O. 
Published: October 2017

Interleukin (IL)‐6−/− mice develop mature onset obesity, whereas i.c.v. injection of IL‐6 decreases obesity in rodents. Moreover, levels of IL‐6 in cerebrospinal fluid (CSF) were reported to be inversely correlated with obesity in humans. Tanycytes lining the base of the third ventricle (3V) in the hypothalamus have recently been reported to be of importance for metabolism. In the present study, we investigated whether tanycytes could respond to IL‐6 in the CSF. With immunohistochemistry using a well characterised antibody directed against the ligand binding receptor for IL‐6, IL‐6 receptor α (IL‐6Rα), it was found that tanycytes, identified by the two markers, vimentin and dopamine‐ and cAMP‐regulated phosphoprotein of 32 kDa, contained IL‐6Rα. There were fewer IL‐6Rα on another type of ventricle‐lining cells, ependymal cells, as identified by the marker glucose transporter‐1. To demonstrate that the immunoreactive IL‐6Rα were responsive to IL‐6, we injected IL‐6 i.c.v. This treatment increased immunoreactive phosphorylated signal transducer and activator of transcription‐3 (pSTAT3) in tanycytes after 5 minutes and in cells in the medial part of the arcuate nucleus after 5 and 15 minutes. Intracerebroventricular injection of leptin exerted similar effects. As expected, i.p. injection of leptin also induced pSTAT3 staining in the hypothalamus, whereas i.p. IL‐6 injection had little effect on this parameter. Intracerebroventricular or i.p. injection of vehicle only had no effect on pSTAT3‐immunoreactivity. In summary, there are functional IL‐6Rα on tanycytes at the bottom of the 3V, in agreement with the possibility that ventricular administration of IL‐6 decreases obesity in mice via an effect on this cell type.
The Share of Systematic Variation in Bilateral Exchange Rates
Authors: VERDELHAN ADRIEN 
Published: October 2017

ABSTRACTSorting countries by their dollar currency betas produces a novel cross section of average currency excess returns. A slope factor (long in high beta currencies and short in low beta currencies) accounts for this cross section of currency risk premia. This slope factor is orthogonal to the high‐minus‐low carry trade factor built from portfolios of countries sorted by their interest rates. The two high‐minus‐low risk factors account for 18% to 80% of the monthly exchange rate movements. The two risk factors suggest that stochastic discount factors in complete markets' models should feature at least two global shocks to describe exchange rates.
Optimal Debt and Profitability in the Trade‐Off Theory
Authors: ABEL ANDREW B. 
Published: October 2017

ABSTRACTI develop a dynamic model of leverage with tax deductible interest and an endogenous cost of default. The interest rate includes a premium to compensate lenders for expected losses in default. A borrowing constraint is generated by lenders' unwillingness to lend an amount that would trigger immediate default. When the borrowing constraint is not binding, the trade‐off theory of debt holds: optimal debt equates the marginal interest tax shield and the marginal expected cost of default. Contrary to conventional interpretation, but consistent with empirical findings, increases in current or future profitability reduce the optimal leverage ratio when the trade‐off theory holds.
Self‐ and informant perceptions of psychopathic traits in relation to the triarchic model
Authors: Kelley Shannon E. , Edens John F. , Donnellan M. Brent , Mowle Elyse N. , Sörman Karolina 
Published: October 2017

AbstractObjectiveThe validity of self‐report psychopathy measures may be undermined by characteristics thought to be defining features of the construct, including poor self‐awareness, pathological lying, and impression management. The current study examined agreement between self‐ and informant perceptions of psychopathic traits captured by the triarchic model (Patrick, Fowler, & Krueger, 2009) and the extent to which psychopathic traits are associated with socially desirable responding.MethodParticipants were undergraduate roommate dyads (N = 174; Mage = 18.9 years; 64.4% female; 59.8% Caucasian) who completed self‐ and informant reports of boldness, meanness, and disinhibition.ResultsSelf‐reports of psychopathic traits reasonably aligned with the perceptions of informants (rs = .36–.60), and both predicted various types of antisocial behaviors, although some associations were only significant for monomethod correlations. Participants viewed by informants as more globally psychopathic did not engage in greater positive impression management. However, this response style significantly correlated with self‐ and informant‐reported boldness, suppressing associations with antisocial behavior.ConclusionsThese findings suggest that participants are willing and able to disclose psychopathic personality traits in research settings under conditions of confidentiality. Nonetheless, accounting for response style is potentially useful when using self‐report measures to examine the nature and correlates of psychopathic traits.