bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alterations in neurovascular coupling following acute traumatic brain injury
Authors: Jang Hyounguk , Huang Stanley , Hammer Daniel X. , Wang Lin , Ye Meijun , Welle Cristin G. , Fisher Jonathan A. N. 
Published: September 2017

AbstractTraumatic brain injury (TBI) is a leading cause of mortality and disability worldwide. A challenge for diagnosing and assessing the severity of TBI, however, is that quantitative biomarkers are lacking. We explored potential functional indicators for TBI by noninvasively monitoring sensory-evoked electrical and hemodynamic activity using a novel hybrid optical and electrophysiological measurement approach. By combining diffuse correlation spectroscopy with co-localized electrophysiological measurements in a mouse model of TBI, we observed concomitant alterations in somatosensory-evoked cerebral blood flow and electrical potentials following controlled cortical impact. Injury acutely reduced the amplitude of stimulus-evoked responses, which mostly recovered to baseline values within 30 min; intertrial variability for these parameters was also acutely altered. The kinetics of recovery, however, varied among specific components of the evoked waveforms, and we observed strong correlations between the two measurement modalities for only a select subset of waveform parameters. Overall, our results identify a novel set of potential biomarkers for TBI and demonstrate the utility of combined, noninvasive optical and electrophysiological measurements for detecting injury-induced abnormalities in neurovascular reactivity.
Cryo-EM shows how dynactin recruits two dyneins for faster movement
Authors: Urnavicius Linas , Lau Clinton K. , Elshenawy Mohamed M. , Morales-Rios Edgar , Motz Carina , Yildiz Ahmet , Carter Andrew P. 
Published: September 2017

AbstractDynein and its cofactor dynactin form a highly processive microtubule motor in the presence of an activating adaptor, such as BICD2. Different adaptors link dynein/dynactin to distinct cargos. Here we use electron microscopy (EM) and single molecule studies to show that adaptors can recruit a second dynein to dynactin. Whereas BICD2 is biased toward recruiting a single dynein, the adaptors BICDR1 and HOOK3 predominantly recruit two. We find that the shift toward a double dynein complex increases both force and speed. A 3.5 Å cryo-EM reconstruction of a dynein tail/dynactin/BICDR1 complex reveals how dynactin can act as a scaffold to coordinate two dyneins side by side. Our work provides a structural basis for how diverse adaptors recruit different numbers of dyneins and regulate the motile properties of the dynein/dynactin transport machine.
A minimal model of protein allocation during phototrophic growth
Authors: Faizi Marjan , Zavřel Tomáš , Loureiro Cristina , Cerveny Jan , Steuer Ralf 
Published: September 2017

AbstractPhotoautotrophic growth depends upon an optimal allocation of finite cellular resources to diverse intracellular processes. Commitment of a certain mass fraction of the proteome to a specific cellular function, typically reduces the proteome available for other cellular functions. Here, we develop a minimal semi-quantitative kinetic model of cyanobacterial phototrophic growth to describe such trade-offs of cellular protein allocation. The model is based on coarse-grained descriptions of key cellular processes, in particular carbon uptake, metabolism, photosynthesis, and protein translation. The model is parametrized using literature data and experimentally obtained growth curves. Of particular interest are the resulting cyanobacterial growth laws as fundamental characteristics of cellular growth. We show that the model gives rise to similar growth laws as observed for heterotrophic organisms, with several important differences due to the distinction between light energy and carbon uptake. We discuss recent experimental data supporting the model results and show that minimal growth models have implications for our understanding of the limits of phototrophic growth and bridge a gap between molecular physiology and ecology.
The actin cytoskeleton governs apical mitosis and daughter cell dispersion in intestinal epithelia
Authors: McKinley Kara L. , Stuurman Nico , Klein Ophir D. , Vale Ronald D. 
Published: September 2017

AbstractCell proliferation is critical for maintaining the absorptive, protective and regenerative functions of the small intestine throughout adulthood. Interphase nuclei are positioned near the basal surface of the intestinal epithelium, but during mitosis, chromosomes are located apically. The molecular basis for apical-basal DNA positioning and its consequences for tissue homeostasis are poorly understood. Here, we image and pharmacologically perturb these behaviors in live murine intestinal organoids. We find that apical and basal DNA movements occur as a result of mitosis-coupled actin rearrangements that alter the basolateral shape of dividing cells, while the apical cell surface remains confined by cell-cell contacts that persist throughout mitosis. Strikingly, these polarized shape changes allow neighboring cells to insert between nascent daughters, intermingling cells of different lineages. In summary, polarized rearrangements of the actin cytoskeleton govern the mitotic behavior of intestinal epithelial cells and lead to interspersion of cell lineages.
Functional traits and community composition: multilevel models outperform community-weighted means
Authors: Miller Jesse E. D. , Damschen Ellen I. , Ives Anthony R. 
Published: September 2017

AbstractPlant functional traits are increasingly being used to infer mechanisms about community assembly and predict global change impacts. Of the several approaches that are used to analyze trait-environment relationships, one of the most popular is community-weighted means (CWM), in which species trait values are averaged at the site level. Other approaches that do not require averaging are being developed, including multilevel models (MLM, also called generalized linear mixed models). However, relative strengths and weaknesses of these methods have not been extensively compared.We investigated three statistical models for trait-environment associations: CWM, a MLM in which traits were not included as fixed effects (MLM1), and a MLM with traits as fixed effects (MLM2). We analyzed a real plant community dataset to investigate associations between two traits and one environmental variable. We then analyzed permutations of the dataset to investigate sources of type I errors, and performed a simulation study to compare the statistical power of the methods.In the analysis of real data, CWM gave highly significant associations for both traits, while MLM1 and MLM2 did not. UsingP-values derived by simulating the data using the fitted MLM2, none of the models gave significant associations, showing that CWM had inflated type I errors (false positives). In the permutation tests, MLM2 performed the best of the three approaches. MLM2 still had inflated type I error rates in some situations, but this could be corrected using bootstrapping. The simulation study showed that MLM2 always had as good or better power than CWM. These simulations also confirmed the causes of type I errors from the permutation study.The MLM that includes main effects of traits (MLM2) is the best method for identifying trait-environmental association in community assembly, with better type I error control and greater power. Analyses that regress CWMs on continuous environmental variables are not reliable because they are likely to produce type I errors.
Eco-efficiency measurement and improvement of Chinese industry using a new closest target method
Authors: Xiong Beibei , Li Yongli , Santibanez Gonzalez Ernesto D.R. , Song Malin 
Published: September 2017

Purpose
The purpose of this paper is to measure Chinese industries’ eco-efficiency during 2006-2013. The Chinese industry attained rapid achievement in recent decades, but meanwhile, overconsumption of energy and environmental pollution have become serious problems. To solve these problems, many research studies used the data envelopment analysis (DEA) to measure the Chinese industry’s eco-efficiency. However, because the target set by these works is usually the furthest one for a province to be efficient, it may hardly be accepted by any province.

Design/methodology/approach
This paper builds a new “closest target method” based on an additive DEA model considering the undesirable outputs. This method is a mixed-integer programming problem which can measure the ecological efficiency of provinces and more importantly guide the province to perform efficiently with minimum effort.

Findings
The results show that the eco-efficiency of Chinese provinces increased at the average level, but the deviations remained at a larger value. Compared to the “furthest” target methods, the targets by the approach proposed by this study are more acceptable for a province to improve its performance on both economy and environment counts.

Originality/value
This study is the first attempt to introduce the closest targets concept to measure the eco-efficiency and set the target for each provincial industry in China.
Organizational adaptation to climate change: learning to anticipate energy disruptions
Authors: Orsato Renato J. , Barakat Simone R. , de Campos José Guilherme F. 
Published: September 2017

Purpose
This paper aims to investigate how organizational learning (OL) affects the development of anticipatory adaptation to climate change in companies. Because the need to learn increases in circumstances of greater uncertainty such as the case of climate change, one of the processes that can explain different levels of anticipatory adaptation to climate change (AACC) by companies is OL.

Design/methodology/approach
The research uses a case study design. Following the procedures of qualitative sampling, an exemplary case of organizational adaptation to climate change in a sector that is extremely affected by the impacts of weather events was chosen. Empirical data collection includes semi-structured interviews and the collection of private and public documents. Such data were analyzed through thematic analysis.

Findings
The process of OL for anticipatory adaptation to climate change presents substantial differences from the traditional OL process presented by the specialized literature. In particular, the concepts of single- and double-loop learning were challenging to fit into the learning processes required for AACC.

Originality/value
Organizations have historically been working towards the adaption to external unforeseen events, but anticipatory adaptation to climate change presents new challenges and requires new forms of learning. Previous research has examined the interplay between learning and climate change adaptation, especially at the inter-organizational level. By developing research at the organizational level, this paper addresses a gap in the literature and shows that the required learning to adapt to climate change differs from the traditional learning, described in the management literature.
Women’s glass ceiling beliefs predict work engagement and burnout
Authors: Balasubramanian Senthil Arasu , Lathabhavan Remya 
Published: September 2017

PurposeThe purpose of this paper is to examine the relationship between glass ceiling beliefs, work engagement, and burnout.Design/methodology/approachA research model was developed based on the constructs from the Career Path Survey (CPS) and a literature review of research related to work engagement and burnout. Data from a cross-sectional study of 467 female employees from banks in India were collated and empirically tested, using structural equation modeling.FindingsDenial and resilience were positively related to work engagement and negatively to burnout. Resignation and acceptance had a positive relationship with burnout and a negative relationship with work engagement.Research limitations/implicationsFurther longitudinal studies focusing on different occupational sectors and career aspects can be considered for a more accurate and generalized insight into this concept.Practical implicationsGlass ceiling survey can be considered as an input for human resource functions for effectiveness of the organization.Originality/valueThis paper is the first to analyze the connection between the beliefs that women have about the glass ceiling and burnout and its components.
The new nowhere land? A research and practice agenda for the “always on” culture
Authors: McDowall Almuth , Kinman Gail 
Published: September 2017

Purpose
Rapid developments in the field of information communication technology (ICT) mean that e-working has become increasingly common and prolonged – the “always-on-culture” potential to enhance work-life balance via increased flexibility in terms of time and location, as well as posing the risk of being “always on” has been identified with potentially serious implications for the health and performance of employees. The authors identify a research agenda as a starting point for reviewing current organisational practice.

Design/methodology/approach
The authors discuss current technological developments as well as prevalent research frameworks and terminology in the domain of work-life balance and beyond to evaluate their fitness for purpose. They also report findings from a survey of 374 employees working within UK businesses about current organisational practice.

Findings
Over half of the organisations sampled do not have clear policies, guidance or training in place regarding work-life balance and supporting employees with regards to technology enabled working and communications. The authors identify as key challenges the sheer volume of e-mail traffic, lack of training and infrastructure to support ICT-enabled working and an absence of appropriate support.

Practical implications
Organisations need to develop clear policies regarding the psychosocial aspects of technology use and provide evidence-based guidance to managers and employees.

Social implications
Managers and individuals require support to engage with technology in a healthy and sustainable way.

Originality/value
This is one of the first papers to survey organisational practice and support on the topic.
Time and change in health care
Authors: Waterworth Susan 
Published: September 2017

Purpose
The purpose of this paper is to explore the dimensions of temporality that are rarely considered in the literature on leading change.

Design/methodology/approach
The analysis is informed by Adams’ (1995) social theory of time encompassing temporality, timing and tempo. This will illustrate the complexities of time as they relate to the individual, teams and organisation.

Findings
This paper demonstrates the multidimensional nature of time: temporality, timing and tempo, and how each of these can contribute to our understanding of the temporal nature and complexity of change within the health system. A framework to inform much-needed research in the area of time and change is presented.

Practical implications
Challenging assumptions that there is only one common time, that is clock time, can provide opportunities for further discussion and understanding of how various people view time and the influence this has on leading and participating in change in health care.

Originality/value
There is limited literature on the temporal dimensions of change at an organisational, team and individual level. The perspective offered in this paper presents the multidimensional nature of time and the influence this has on understanding the temporal nature of change and critically identifies some key areas for future research.
Product knowledge and salesperson performance: rethinking the role of optimism
Authors: Sangtani Vinita , Murshed Feisal 
Published: September 2017

Purpose
Based on knowledge-based view of the firm, and salesperson attributions, the purpose of this paper is to develop and test a contingency-based framework featuring how salespeople’s product knowledge: product and brand knowledge (PBK) and competitors’ product and brand knowledge (CPBK) and optimism impact salesperson performance.

Design/methodology/approach
Hypotheses are tested on survey data from 185 car salespeople in Southeast USA.

Findings
Results document support for the main effects of PBK, CPBK, and their joint effects. Furthermore, under high optimism, the positive impact of CPBK on salesperson performance is attenuated. However, optimism × PBK interaction was not supported.

Research limitations/implications
Extant literature lacks insights into the impact of salespeople’s product knowledge. By examining salespeople’s product knowledge in a disaggregated fashion, and the interaction of product knowledge × optimism, this research highlights the multi-dimensional nature of product knowledge, whose complex ramifications cannot otherwise be uncovered by a globally conceptualized construct.

Originality/value
This study isolates salespeople’s domain-specific knowledge of products from the more global construct of salespeople’s knowledge. The focus on how PBK and CPBK exert a joint positive influence on performance is novel. In addition, by examining how optimism weakens the relationship between CPBK and performance, this research provides a notable contrast to extant findings and broadens the learned optimism paradigm.
Compensation study of Boboroku, Jesse, Delta State, Nigeria
Authors: Odudu Christopher Oghenegweke , Iruobe Patience Osaiwie 
Published: September 2017

Purpose
The purpose of this paper is to examine issues of compulsory acquisition, evaluating the quantum of compensation paid to natives of communities whose farmlands are acquired and issues that must be dealt with to provide adequate compensation to claimants.

Design/methodology/approach
Using an oil well acquisition base in Boboroku, Jesse in Ethiope-West local government area of Delta State as a case study, various compensation claims were examined vis-à-vis market value claims in compulsory acquisition.

Findings
It was found that many claimants received N1,000.00 (naira) or less as full compensation claims for their crops while families lucky to own lands received more reasonable payments. It was also found that 40 of the 142 claimants in Boboroku community received only N4,146,120.00 as opposed to N8,802,750.00 they should have received under market values. Similarly, 39 claimants in Okuno should have received a market value of N3,195,920.00 as against N1,370,609.00 that was actually paid by the acquiring authority confirming that the rates applied were grossly inadequate.

Practical implications
It was established that there was no statutory provision for disturbance losses from revocation of land interests. Also, the productivity of economic crops and trees was not considered nor was the computation of claims based on market values. The paper further established that claims should be compensated on the basis of productivity value and life span of interests being acquired and not on arbitrary rates supplied by the acquiring authorities.

Originality/value
The case study methodology used in this paper enabled contribution to the body of studies which hitherto highlighted the issues of compulsory acquisition and quantum of compensation. It, therefore, adds to the problem-solving framework on compulsory purchase matters in Nigeria.
Social Disadvantage and Education
Authors: Ryan Chris 
Published: September 2017

Abstract‘Social disadvantage’ has many dimensions studied in various ways in the economics of education. Studies focus on its measurement, the characteristics of those experiencing it, its consequences and interventions to remedy some of its effects. Those likely to experience persistent disadvantage include lone parents, Indigenous Australians, people with disabilities and people with low educational attainment. It is children from these families whose educational progress we should closely monitor. Interventions can improve outcomes for disadvantaged children, but such programs need to be evaluated more rigorously in the future, and their evaluations released publicly to provide a sounder basis for future policy.
Time for a New Paradigm? Past and Present Transitions in Economic Policy
Authors: Stirling Alfie , Laybourn‐Langton Laurie 
Published: September 2017

AbstractThis article seeks to place the UK's present economic ‘moment’ in historical context. Over the course of the decade since the 2007 financial crisis, it has increasingly been acknowledged that a cyclical crisis has become a structural crisis. The failure of most economists to predict the financial crash in the first place, and the inadequacy of economic policy in responding to its lasting effects, has led many to conclude that economics itself is in crisis. This article seeks to contribute to a better understanding of the present period of disjuncture. Drawing on theories of paradigm shift from both the physical and social sciences, we argue that the speed of change in UK economic policy is comparable to the two major historical transitions that ended with the post‐war consensus and neoliberalism. We conclude by offering some remarks on how and where the present change might take us.
Gonadotrophin‐releasing hormone agonist combined with high‐intensity focused ultrasound ablation for adenomyosis: a clinical study
Authors: Guo Y , Duan H , Cheng J , Zhang Y 
Published: September 2017

ObjectivesThis study was to investigate the clinical efficacy of a gonadotrophin‐releasing hormone agonist (GnRH‐a) combined with high‐intensity focused ultrasound (HIFU) ablation treatment for adenomyosis.DesignA non‐randomized prospective study.SettingGynaecological Minimally Invasive Centre in a single hospital.PopulationPatients with adenomyosis.MethodsSeventy‐nine patients with adenomyosis were enrolled, including 55 patients in the control group treated with only HIFU and 24 patients in the study group treated with GnRH‐a combined with HIFU. All the patients follow up 6 months after the HIFU procedure. The related parameters in the two groups were assessed before and 3 months as well as 6 months after treatment including serum levels of tumor marker and cytokine, volumes of uterine, adenomyotic lesion, and menstrual blood, as well as dysmenorrheal scores.Main outcome measuresDifferences between the group treated with HIFU alone and the group treated with GnRH‐a combined with HIFU.ResultsBefore HIFU treatment, no significant difference was observed in serum levels of CA125, CA19‐9, and interleukin‐6 (IL‐6), the volumes of uterine, adenomyotic lesion, and menstrual blood, as well as dysmenorrhea scores between the two groups. (P > 0.05). The serum CA125 levels significantly decreased in both groups after HIFU, but the serum CA125 levels in the study group were still significantly lower than those in the control group (P < 0.05). The volume of uterine and adenomyotic lesion significantly decreased in both groups after HIFU procedure, and decreased even more in the study group 3 and 6 months after treatment (P < 0.05). Dysmenorrhea scores and menstruation volumes significantly decreased in both groups after HIFU treatment. Moreover in the study group were significantly lower than those in the control group after 3 and 6 months (P < 0.05). No significant difference was observed in the rate of adverse effects between the two groups.ConclusionsThe short‐term follow‐up results indicate that the combination of GnRH‐a and HIFU treatment significantly decreased serum CA125 levels, volumes of uterine, adenomyotic lesion and menstrual blood, as well as dysmenorrhea scores, and improved the clinical outcomes compared with the HIFU ablation alone in patients with adenomyosis. However, the further follow‐up is needed to explore the long‐term effects.Tweetable abstractA combination of GnRH‐a with HIFU in the treatment of adenomyosis significantly decreased serum CA125 levels, uterine and adenomyotic lesion volumes, dysmenorrhea scores, and menstrual blood volumes.