bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intervention Study with Algoplus®: A Pain Behavioral Scale for Older Patients in the Emergency Department
Authors: Moustafa Fares , Macian Nicolas , Giron Fatiha , Schmidt Jeannot , Pereira Bruno , Pickering Gisèle 
Published: October 2016

AbstractObjectivesEvaluation of acute pain is often difficult in older patients admitted to the Emergency Department (ED), and self‐evaluation of pain is not always possible. This observational study evaluates how the systematic use of Algoplus®, a validated behavioral scale, could improve pain management of older persons admitted to the ED.MethodThe intervention study (NCT 02258503) took place in 4 steps in the ED, University Hospital Clermont‐Ferrand, France. Pain assessment and analgesics prescription were collected from medical files for 3 months. For 6 months, the whole staff of the ED were trained on pain assessment and to use Algoplus® scale (3—same as step 1). To evaluate the intervention, pain assessment and analgesics prescription were compared before and after implementation by 2‐sided tests with a type I error set at α = 0.05.ResultsThe intervention led to systematic pain evaluation with Algoplus® in 100% of patients (≥ 75 years old, n = 434) and was completed by numeric rating scale (NRS) and other evaluations. Pearson's correlation between NRS ≥ 3 and Algoplus® < 2 was 0.61. Prescription of analgesics (+6%) especially opioids increased nonsignificantly but was similar for all patients whatever the evaluation.ConclusionsThe systematic introduction of Algoplus® scale in the ED allowed a change in practice by improving evaluation and management of pain in patients ≥ 75 years old, especially when difficult to be evaluated. Algoplus® allowed an objective levelling of analgesics prescription in all admitted patients. It also promoted field action to improve pain management in ED.
ERF105 is a transcription factor gene of Arabidopsis thaliana required for freezing tolerance and cold acclimation
Authors: Bolt Sylvia , Zuther Ellen , Zintl Stefanie , Hincha Dirk K. , Schmülling Thomas 
Published: October 2016

AbstractUnderstanding the response to cold temperature stress is relevant for both basic biology and application. Here we report on ERF105, which is a novel cold‐regulated transcription factor gene of Arabidopsis that makes a significant contribution to freezing tolerance and cold acclimation. The expression of cold‐responsive genes in erf105 mutants suggests that its action is linked to the CBF regulon mediating cold responses.
Post‐transplant blood transfusions and pediatric renal allograft outcomes
Authors: Verghese Priya , Gillingham Kristen , Matas Arthur , Chinnakotla Srinath , Chavers Blanche 
Published: October 2016

AbstractThe association of blood transfusions with GS after pediatric KTx is unclear. We retrospectively analyzed blood transfusions post‐KTx and subsequent outcomes. Between 1984 and 2013, 482 children (<18 years of age) underwent KTx at our center. Recipient demographics, outcomes and transfusion data were collected. Cox regression with post‐KTx blood transfusion as a time‐dependent covariate was performed to model the impact of blood transfusion on outcomes. Of the 208 (44%) that were transfused, 39% had transfusion <1 month post‐KTx; 48% >12 months. Transfused and non‐transfused recipients were not significantly different. In univariate and multivariate analyses, there was no difference between transfused and non‐transfused recipient patient survival, antibody‐mediated and ACR, and DSA free survival. Transfusions <1 month post‐KTx did not impact DCGS (P=NS). Patients transfused >12 months post‐KTx had significantly lower 12 month eGFR (compared to non‐transfused) and worse subsequent DCGS. Post‐KTx blood transfusions have increased in pediatric KTx over time but have no negative association with rejection or DSA production. DCGS is unaffected by transfusion within first month. Transfusions after the first year occur in patients with more advanced chronic kidney disease and are associated with significantly worse DCGS.
Epidemiology, risk factors, and prognosis of capillary leak syndrome in pediatric recipients of stem cell transplants: a retrospective single‐center cohort study
Authors: Lucchini Giovanna , Willasch Andre Manfred , Daniel Julia , Soerensen Jan , Jarisch Andrea , Bakhtiar Shahrzad , Rettinger Eva , Brandt Joerg , Klingebiel Thomas , Bader Peter 
Published: October 2016

AbstractCLS involves sudden loss of intravascular fluids into the interstitial spaces. CLS was described as a possible complication after SCT. Few studies report the incidence of CLS in pediatric populations. We aimed to assess CLS incidence, its risk factors, and impact on the survival. The clinical charts of patients <18 years of age transplanted at our institution between 2002 and 2012 were reviewed. CLS was defined by weight gain >3% in 24 hours and positive intake balance despite furosemide administration. In total, 234 patients underwent 275 allogeneic SCT procedures in the analyzed time frame. Fifteen patients developed CLS (5.4%). The probability of developing CLS was significantly increased in patients suffering from sepsis (14.3% vs 0.6%, P<.001). Patients with CLS exhibited an increased risk of acute GvHD in the first 30 days after SCT (10.8% vs 1.8%, P=.002). Ten of the patients with CLS required intensive care. CLS strongly impacts OS at day +100 after SCT and is a predictive factor of TRM at the same date (42.9% vs 5%, P<.0001). The biological relation among sepsis, GvHD, and CLS development in terms of cytokine release and endothelial damage warrants further studies.
Factors Associated with HPV Vaccination among Cambodian American Teenagers
Authors: Lee Haeok , Kim Minjin , Kiang Peter , Shi Ling , Tan Kevin , Chea Phala , Peou Sonith , Grigg‐Saito Dorcas C. 
Published: October 2016

AbstractObjectivesParents have general influence over their children's health and health behavior. However, given the dearth of specific literature regarding knowledge level and social and cultural factors influencing HPV vaccination behaviors among Cambodian American (CA) parent, it is difficult to develop an effective, evidence‐based public health HPV vaccination program. Therefore, the objectives of this study were to determine the HPV vaccine uptakes among CA teenagers and to examine factors influencing HPV vaccine uptakes.Design and SampleA descriptive, cross‐sectional survey design and a combination of network and targeted sampling methods were used.ResultsCA mothers (n = 130) completed a health survey through face‐to‐face interviews in either English or Khmer language. Girls vaccination rates were 29% while that of boys was 16%. Awareness and knowledge of HPV among CA mothers was very low, and many believed that their daughters, who speak English and were educated in the U.S., had more knowledge about health than they did. Logistic regression analysis showed that CA girls had significantly higher odds of vaccination when their mothers possessed a higher level of English reading ability and had greater awareness and knowledge of HPV.ConclusionsThe strikingly low rates of HPV vaccination among CA girls and boys underscore the need to improve vaccination outreach, education, and uptake. The findings can be used to develop targeted public health HPV vaccination programs for CAs, which will reduce cervical cancer disparities.
Tobacco Smoke Pollution in Hospitality Venues Before and After Passage of Statewide Smoke‐Free Legislation
Authors: Buettner‐Schmidt Kelly , Boursaw Blake , Lobo Marie L. , Travers Mark J. 
Published: October 2016

AbstractObjectiveIn 2012, North Dakota enacted a comprehensive statewide law prohibiting smoking in enclosed public places. Disparities in tobacco control exist in rural areas. This study's objective was to determine the extent to which the passage of a comprehensive, statewide, smoke‐free law in a predominantly rural state influenced tobacco smoke pollution in rural and nonrural venues.Design and SampleA longitudinal cohort design study comparing the levels of tobacco smoke pollution before and after passage of the statewide smoke‐free law was conducted in 64 restaurants and bars statewide in North Dakota.MeasuresParticulate matter with a median aerodynamic diameter of <2.5 μm (a valid atmospheric marker of tobacco smoke pollution) was assessed.ResultsA significant 83% reduction in tobacco smoke pollution levels occurred after passage of the law. Significant reductions in tobacco smoke pollution levels occurred in each of the rural categories; however, no difference by rurality was noted in the analysis after passage of the law, in contrast to the study before passage.ConclusionsTo our knowledge, this was the largest, single, rural postlaw study globally. A comprehensive statewide smoke‐free law implemented in North Dakota dramatically decreased the level of tobacco smoke pollution in bars and restaurants.
Effects of blast on components of wheat physiology and grain yield as influenced by fungicide treatment and host resistance
Authors: Rios J. A. , Rios V. S. , Paul P. A. , Souza M. A. , Neto L. B. M. C. , Rodrigues F. A. 
Published: October 2016

Two field experiments (Exp. 1 and Exp. 2) were carried out to assess the physiological performance and grain yield of wheat cultivars BR‐18 (moderately resistant) and Guamirim (susceptible) inoculated with Pyricularia oryzae in plots treated or untreated with Ópera (fungicide 13.3% epoxiconazole + 5% pyraclostrobin). Results from regression analyses indicated that spike and leaf blast severity at 10–14 days after inoculation (dai) were associated with greater yield losses (highest negative slope) than severity at 18–22 dai. Relative to untreated Guamirim, there were 0.3% and 16% increases in Exp. 1 and 2, respectively, for untreated BR‐18 (resistance alone). For fungicide treatment alone, the mean yield of Guamirim increased by 20% and 61% in Exp. 1 and 2, respectively, relative to the untreated fungicide control, whereas for the fungicide treated BR‐18, the mean yield increased by 26% and 83% in Exp. 1 and 2, respectively. Fungicide application and cultivar resistance resulted in higher measures of leaf health and photosynthetic performance in both spikes and leaves than in the untreated susceptible reference treatment. The results from this study may be useful in future efforts to develop crop loss models and management guidelines for wheat blast.
The electrophysiological signature of deliberate rule violations
Authors: Pfister Roland , Wirth Robert , Schwarz Katharina A. , Foerster Anna , Steinhauser Marco , Kunde Wilfried 
Published: October 2016

AbstractHumans follow rules by default, and violating even simple rules induces cognitive conflict for the rule breaker. Previous studies revealed this conflict in various behavioral measures, including response times and movement trajectories. Based on these experiments, we investigated the electrophysiological signature of deliberately violating a simple stimulus‐response mapping rule. Such rule violations were characterized by a delayed and attenuated P300 component when evaluating a rule‐relevant stimulus, most likely reflecting increased response complexity. This parietal attenuation was followed by a frontal positivity for rule violations relative to correct response trials. Together, these results reinforce previous findings on the need to inhibit automatic S‐R translation when committing a rule violation, and they point toward additional factors involved in rule violation. Candidate processes such as negative emotional responses and increased monitoring should be targeted by future investigations.
Pupillometry reveals changes in physiological arousal during a sustained listening task
Authors: McGarrigle Ronan , Dawes Piers , Stewart Andrew J. , Kuchinsky Stefanie E. , Munro Kevin J. 
Published: October 2016

AbstractHearing loss is associated with anecdotal reports of fatigue during periods of sustained listening. However, few studies have attempted to measure changes in arousal, as a potential marker of fatigue, over the course of a sustained listening task. The present study aimed to examine subjective, behavioral, and physiological indices of listening‐related fatigue. Twenty‐four normal‐hearing young adults performed a speech‐picture verification task in different signal‐to‐noise ratios (SNRs) while their pupil size was monitored and response times recorded. Growth curve analysis revealed a significantly steeper linear decrease in pupil size in the more challenging SNR, but only in the second half of the trial block. Changes in pupil dynamics over the course of the more challenging listening condition block suggest a reduction in physiological arousal. Behavioral and self‐report measures did not reveal any differences between listening conditions. This is the first study to show reduced physiological arousal during a sustained listening task, with changes over time consistent with the onset of fatigue.
Hardwood management and restoration of longleaf pine ecosystems may affect raccoon daytime resting sites
Authors: Kirby Ronald B. , Muller Lisa I. , Chamberlain Michael J. , Conner Mike 
Published: October 2016

AbstractFire‐maintained Pinus palustris (longleaf pine) ecosystems are species rich and considered a top conservation priority in the southeastern United States. Ground‐nesting species such as Gopherus polyphemus (gopher tortoise) and Colinus virginianus (northern bobwhite) thrive in longleaf ecosystems. However, the generalist carnivore Procyon lotor (raccoon) is a significant predator of these endemic ground nesters. In forested ecosystems, raccoons prefer hardwood‐dominated habitats. Removal of hardwood trees, which is a common longleaf pine ecosystem restoration tool, affects habitat use of this predator. We examined 269 daytime resting sites (DRS) associated with 31 radio‐collared adult raccoons (18 M, 13 F) during 2014–2015 on a longleaf pine‐dominated site in southwestern Georgia. We developed 26 a priori models using an information theoretic approach to evaluate factors affecting use of DRS by raccoons. The top two models (ΔAIC < 2) had combined model weights of 0.75 and contained tree diameter, tree type, presence of nearby hardwood, and distances to pine, hardwood, mixed forest, and agriculture as predictors. However, the only informative variables were tree type and tree diameter. Raccoons used DRS in all available forest types, but were less likely to use pine trees (n = 7) relative to hardwoods (n = 247), and there was a positive relationship with tree diameter. Females used smaller trees farther from agriculture and primary roads, and were closer to wetlands than those used by males. Hardwood removal from within longleaf pine ecosystem affects habitat use of this predator, specifically DRS.
Does restored plant diversity play a role in the reproductive functionality of Banksia populations?
Authors: Ritchie Alison L. , Nevill Paul G. , Sinclair Elizabeth A. , Krauss Siegfried L. 
Published: October 2016

AbstractVegetation structure and plant species diversity of restoration sites are predicted to directly affect pollinator attraction, with potential impacts on gene flow, reproduction, genetic diversity of future generations, and ultimately restoration success. We compared Banksia attenuata R.Br. (Proteaceae) in a low species diversity restoration site and an adjacent natural remnant. We assessed fecundity genetic diversity in adult plants and their offspring, mating system parameters and pollen dispersal using paternity assignment. Results were compared to an earlier study of reproductive functionality within a high species diversity restoration site that was restored in a similar manner, enabling us to investigate any association between plant species diversity and fecundity. Seed set data indicated no significant differences between restored and adjacent natural sites; however, seed set data between restoration sites was significantly different (2.08 ± 0.39 and 6.89 ± 1.12, respectively). The mean number of fruits (follicles) per inflorescence was not significantly different between restoration sites. Genetic diversity of adult plants and their offspring were comparable in all sites. Higher allelic richness and genetic differentiation in one restored site reflected sourcing beyond local provenance. Low correlated paternity indicated high levels of multiple siring of seeds and paternity assignment demonstrated strong genetic connectivity between sites. Reproductive functionality, as measured by fecundity and genetic diversity in the offspring of B. attenuata, is resilient to low species diversity within a restored plant community. We consider our results in the context of establishing seed production areas (SPAs) that maximize the quantity and genetic quality of Banksia seeds for restoration.
Lung function in patients with lung injury due to household chemical inhalation: Post hoc analysis of a prospective nationwide cohort
Authors: Kim Won‐Young , Park Soonyoung , Kim Hwa Jung , Chae Eun Jin , Do Kyung‐Hyun , Huh Jin Won , Lim Chae‐Man , Koh Younsuck , Hong Sang‐Bum 
Published: October 2016

ABSTRACT
Background and objectiveInhalation exposure to household chemicals can result in serious health problems, although the long‐term outcomes are unclear. We evaluated the changes in lung function after home humidifier disinfectant (HD) exposure.MethodsThis post hoc analysis of a prospective nationwide cohort involved patients with inhalation lung injury due to HD. Patients underwent spirometric measurements at onset and annually thereafter.ResultsForty subjects met the eligibility criteria. Overall, mean forced vital capacity (FVC) increased significantly during the first 3 years from 2.10 ± 0.74 to 3.06 ± 1.08 L. Mean forced expiratory volume in 1 s (FEV
1) also rose from 1.84 ± 0.63 to 2.62 ± 0.88 L. Both variables then stabilized. However, in 19 (48%) patients, the FVCs did not normalize. Compared to subjects with an FVC at onset of <2.5 L, subjects with onset FVC ≥2.5 L exhibited significantly more improvement in percent predicted FVC over time (group × time interaction: P < 0.001). Patients with lower exposure also exhibited increasing percent predicted FVC over time, whereas more exposed patients showed a plateau starting at year 1. On multivariate analysis, onset FVC < 2.5 L associated significantly with <80% predicted FVC at year 4 (adjusted OR: 20.33; 95% CI: 1.10–376.53; P = 0.04).ConclusionHalf of the patients with inhalation injury exhibited stabilization of lung function within several years of onset. However, lung function was impaired in the remaining patients. This impairment associated with lung function at onset and exposure intensity.
New multiproxy record of the Jenkyns Event (also known as the Toarcian Oceanic Anoxic Event) from the Mecsek Mountains (Hungary): Differences, duration and drivers
Authors: Müller Tamás , Price Gregory D. , Bajnai Dávid , Nyerges Anita , Kesjár Dóra , Raucsik Béla , Varga Andrea , Judik Katalin , Fekete József , May Zoltán , Pálfy József 
Published: October 2016

AbstractThe oceanic anoxic event in the Early Toarcian, often referred to as the ‘Torcian Oceanic Anoxic Event’, led to widespread deposition of organic‐rich black shales and geochemical anomalies in elemental distribution and multiple isotope systems in the Early Jurassic ocean. Best characterized by its hallmark carbon isotope anomaly, the event is widely regarded as a prime example of rapid greenhouse warming‐related changes in the Mesozoic Earth system. However, despite numerous studies, details of its forcing mechanisms, exact duration and the role of regional effects remain debated. This article presents new data (high‐resolution organic carbon isotope, calcareous nannofossil and elemental geochemical analyses) from the black shale‐bearing Lower Toarcian section in the Réka Valley, Hungary, with the aim of assessing any regional differences in the sedimentary and geochemical record and their bearing on the underlying oceanographic and climatic processes. Following a short segment with a positive trend at the base of the section, values of the carbon isotope data here are turning to a negative trend with a steep, stepwise drop in two negative shifts, reaching their minimum before a positive trend with oscillations characterizing the top part of the section examined. The shape of the curve and nannoplankton biostratigraphy (recognition of zones NJ5b, NJ6 and NJ7) allow reliable correlation of these data with the global carbon isotope perturbation recorded elsewhere in the Early Toarcian. It is proposed here that it would be fitting to rename the Torcian Oceanic Anoxic Event as the ‘Jenkyns Event’, to honour the seminal contributions of Hugh Jenkyns. The cyclostratigraphic analysis in this study suggests that the duration of the negative isotope excursion at Réka Valley is 200 kyr, 350 kyr or 1 Myr, depending on which astronomical forcing parameter controls the most prominent cyclicity. Spectroscopic analyses suggest that the source of the organic matter, marine algae according to previous studies, did not change considerably during the main negative carbon isotope excursion. The variability observed in major element concentrations and enrichments relative to the average shale in the Réka Valley black shales can be regarded as mixtures of terrigenous aluminosilicates and calcium carbonate as two endmembers. Consequently, the terrigenous compositional endmember of the studied black shales consists of a mixture of an illitic/smectitic and a kaolinitic clay, which supports previous suggestions of increased weathering under extremely humid climate in the hinterland during the Jenkyns Event.
The use and modification of injury prevention exercises by professional youth soccer teams
Authors: O'Brien J. , Young W. , Finch C. F. 
Published: October 2016

The efficacy of injury prevention exercise programs (IPEPs) for amateur youth soccer has been established, but little is known about their adaptability to other soccer populations. This study aimed to assess the use of individual injury prevention exercises by professional youth soccer teams, against the industry‐standard, FIFA 11+ program. Four teams' chosen IPEPs were observed across one season and documented on a standardized form. The use of each FIFA 11+ exercise was coded as “performed”, “performed modified” or “not performed”. The proportion of the 160 observed sessions containing each individual exercise was calculated. Staff provided reasons for their use and modification of FIFA 11+ exercises. On average, individual FIFA 11+ exercises were conducted in original form in 12% of the sessions (range 0–33%), and in modified form in 28% of sessions (range 2–62%). The five most frequently observed exercises, in either original or modified form, were “bench” (72%), “squats” (69%), “running straight” (68%), “single‐leg stance” (66%), and “sideways bench” (64%). Staff modified exercises to add variation, progression, and individualization, and to align with specific training formats and goals. Professional youth soccer teams often use injury prevention exercises similar to those in the FIFA 11+, but tailor them considerably to fit their implementation context.