bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coherent Tropical Indo-Pacific Interannual Climate Variability
Authors: Wieners Claudia E. , de Ruijter Will P. M. , Ridderinkhof Wim , von der Heydt Anna S. , Dijkstra Henk A. 
Published: February 2016

AbstractA multichannel singular spectrum analysis (MSSA) applied simultaneously to tropical sea surface temperature (SST), zonal wind, and burstiness (zonal wind variability) reveals three significant oscillatory modes. They all show a strong ENSO signal in the eastern Pacific Ocean (PO) but also a substantial SST signal in the western Indian Ocean (IO). A correlation-based analysis shows that the western IO signal contains linearly independent information on ENSO. Of the three Indo-Pacific ENSO modes of the MSSA, one resembles a central Pacific (CP) El Niño, while the others represent eastern Pacific (EP) El Niños, which either start in the central Pacific and grow eastward (EPe) or start near Peru and grow westward (EPw). A composite analysis shows that EPw El Niños are preceded by cooling in the western IO about 15 months earlier. Two mechanisms are discussed by which the western IO might influence ENSO. In the atmospheric bridge mechanism, subsidence over the cool western IO in autumn (year 0) leads to enhanced convection above Indonesia, strengthening easterlies over the western PO, and the creation of a large warm water volume. This is essential for the creation of (EP) El Niños in the following spring–summer. In the state-dependent noise mechanism, a cool western IO favors a strong intraseasonal zonal wind variability over the western PO in early spring (year 1), which can partly be attributed to the Madden–Julian oscillation. This intraseasonal variability induces Kelvin waves, which in early spring lead to a strong warming of the eastern PO and can initiate EPw El Niños.
Hydrologic Evaluation of NWP-Adjusted CMORPH Estimates of Hurricane-Induced Precipitation in the Southern Appalachians
Authors: Zhang Xinxuan , Anagnostou Emmanouil N. , Vergara Humberto 
Published: February 2016

AbstractSatellite-retrieved precipitation has the potential to support flood modeling in mountainous areas. However, to reach this potential satellite estimates need to be corrected for the severe underestimation exhibited in orography-induced heavy precipitation events (HPEs). This paper assesses an existing satellite precipitation error correction technique driven by high-resolution numerical weather prediction (NWP) simulations of HPEs in complex terrain. The study is based on NOAA Climate Prediction Center morphing technique (CMORPH) high-resolution precipitation estimates of six such events induced by hurricane landfalls in the southern Appalachian mountainous region. A distributed hydrological model (Coupled Routing and Excess Storage model) is applied to evaluate the impact of the proposed satellite precipitation error correction on flood simulations for 20 basins of various sizes in this mountainous region. The results demonstrate significant improvements due to the NWP-based adjustment technique in terms of both the precipitation error characteristics and corresponding runoff simulations. These improvements are shown to be comparable to those from the postprocessed gauge-adjusted CMORPH precipitation product, which is promising for advancing hydrologic uses of satellite rainfall in mountainous areas lacking ground observations.
Balance Disorders in the Elderly
Authors: Soto-Varela Andrés , Rossi-Izquierdo Marcos , Faraldo-García Ana , Vaamonde-Sánchez-Andrade Isabel , Gayoso-Diz Pilar , del-Río-Valeiras María , Lirola-Delgado Antonio , Santos-Pérez Sofía 
Published: February 2016

Objectives: To analyze the equilibriometric differences between 2 populations of elderly patients (young elderly and very elderly) with instability induced solely by age. Methods: Cross-sectional study, with 2 study groups classified according to patient age (cut-points in twenty-fifth and seventy-fifth percentiles of the age of the sample). Population: 64 patients aged 65 years or more. Two groups of 32 subjects were established: group A (people 65 years of age or older but less than 72.6, twenty-fifth percentile) and group B (patients 82.5 years, seventh-fifth percentile, or older). Main analyzed variables: timed up-and-go test, sensory organization test of the computerized dynamic posturography, Dizziness Handicap Inventory (DHI), and Short Falls Efficacy Scale-International (FES-I) questionnaires. Student’s t test or the Mann-Whitney test were used. Results: The older patients obtain poorer scores in the equilibriometric tests but not in all of them. In the sensory organization test, the older patients make poorer use of visual and vestibular information; they also require more time and steps for the timed up-and-go. With regards to the questionnaires, fear of falling is greater (higher Short FES-I scores) but not subjective perception of disability (DHI scores without differences). Conclusions: There is a need to establish aged subgroups of elderly patients with instability, adapting therapeutic strategies.
Advance care planning in motor neuron disease: A qualitative study of caregiver perspectives
Authors: Murray Leigh , Butow Phyllis N , White Kate , Kiernan Matthew C , D’Abrew Natalie , Herz Helen 
Published: February 2016

Background: Motor neuron disease is a fatal disease, characterised by progressive loss of motor function, often associated with cognitive deterioration and, in some, the development of frontotemporal dementia. Life-sustaining technologies are available (e.g. non-invasive ventilation and enteral nutrition) but may compromise quality of life for some patients. Timely commencement of ‘Advance Care Planning’ enables patients to participate in future care choices; however, this approach has rarely been explored in motor neuron disease. Aim: We aimed to investigate caregiver perspectives on the acceptability and impact of advance care planning, documented in a letter format, for patients with motor neuron disease and caregivers. Design: This is a qualitative cross-sectional study. Data were analysed by a narrative synthesis approach. Participants and setting: Structured interviews were held with 18 former caregivers of deceased patients with motor neuron disease. A total of 10 patients had created a disease-specific advanced directive, ‘Letter of Future Care’, and 8 had not. Results: A total of four global themes emerged: Readiness for death, Empowerment, Connections and Clarifying decisions and choices. Many felt the letter of future care was or would be beneficial, engendering autonomy and respect for patients, easing difficult decision-making and enhancing communication within families. However, individuals’ ‘readiness’ to accept encroaching death would influence uptake. Appropriate timing to commence advance care planning may depend on case-based clinical and personal characteristics. Conclusion: Advance care planning can assist patients to achieve a sense of control and ‘peace of mind’ and facilitates important family discussion. However, the timing and style of its introduction needs to be approached sensitively. Tools and strategies for increasing the efficacy of advance care planning for motor neuron disease should be evaluated and implemented.
IL-6, IL-8, IP-10, MCP-1 and G-CSF are significantly increased in cerebrospinal fluid but not in sera of patients with central neuropsychiatric lupus erythematosus
Authors: Yoshio T , Okamoto H , Kurasawa K , Dei Y , Hirohata S , Minota S 
Published: February 2016

Objective To determine whether the intrathecal concentrations of cytokines/chemokines are associated with, or influenced by, serum concentrations in patients with central neuropsychiatric systemic lupus erythematosus (NPSLE), and to ascertain whether the increased production of cytokines/chemokines intrathecally relative to serum levels is associated with the presence of central NPSLE. Methods 52 SLE patients (30 with central NPSLE and 22 with non-NPSLE), for whom the CSF and serum samples were obtained at the same time, were enrolled. 27 kinds of cytokine/chemokine concentrations other than IFN-α in the cerebrospinal fluid (CSF) and serum samples were measured by Bio-Plex Pro Assays. IFN-α concentration and anti-ribosomal P protein antibody (anti-P) titres in CSF and serum samples were measured by ELISA. Results The mean concentrations of IL-6, IL-8, IP-10, MCP-1, G-CSF and GM-CSF were higher in the CSF than in the sera, respectively, while the mean concentrations of other 22 cytokines/chemokines, including RANTES and IFN-α, in the CSF were much lower than those in the sera, respectively. Furthermore, the concentrations of IL-6, IL-8, IP-10, MCP-1 and G-CSF in the CSF of the 30 patients with NPSLE were significantly higher than in the 22 patients with non-NPSLE ( p = 6.82 × 10−5, p = 0.00037, p = 0.0028, p = 0.00065, and p = 0.0001, respectively), while the concentration of GM-CSF in the CSF of the 30 patients with NPSLE was not significantly higher than in the 22 patients with non-NPSLE. Most importantly, the largest difference occurred in CSF IL-6 concentrations. A significant positive correlation between CSF anti-P titres and serum anti-P titres in 52 patients with SLE ( r = 0.6316, p = 6.44 × 10−6) was found, while no significant positive correlation was observed between CSF levels and serum levels of each cytokine/chemokine in the 52 SLE patients. Conclusion In central NPSLE the production of IL-6, IL-8, IP-10, MCP-1 and G-CSF might take place in the central nervous system (CNS). These increased CSF cytokines/chemokines along with anti-P might have a prerequisite role in the pathogenesis of central NPSLE.
Fatigue in multiple sclerosis: The contribution of occult white matter damage
Authors: Bisecco Alvino , Caiazzo Giuseppina , d’Ambrosio Alessandro , Sacco Rosaria , Bonavita Simona , Docimo Renato , Cirillo Mario , Pagani Elisabetta , Filippi Massimo , Esposito Fabrizio , Tedeschi Gioacchino , Gallo Antonio 
Published: February 2016

Background: A functional cortico-subcortical disconnection has been recognized in fatigued multiple sclerosis (MS) patients. Normal appearing white matter (NAWM) damage might contribute to the abovementioned disconnectivity. Objectives: To assess the relationship between fatigue and microstructural NAWM damage in relapsing-remitting (RR) MS. Methods: Sixty RRMS patients and 29 healthy controls (HC) underwent a magnetic resonance imaging (MRI) protocol including diffusion tensor imaging (DTI). Patients with a mean Fatigue Severity Scale (FSS) score ⩾ 4 were considered fatigued (fatigued MS (F-MS)). Tract-based spatial statistics were applied for voxel-wise analysis of DTI indices. A correlation analysis was performed between FSS score and DTI indices in the entire MS group. Results: Thirty MS patients were F-MS. Compared to HC, F-MS patients showed a more extensive NAWM damage than not fatigued MS (NF-MS) patients, with additional damage in the following tracts: frontal and occipital juxtacortical fibers, external capsule, uncinate fasciculus, forceps minor, superior longitudinal fasciculus, cingulum, and pons. No differences were found between F-MS and NF-MS patients. Fatigue severity correlated to DTI abnormalities of corona radiata, cingulum, corpus callosum, forceps minor, superior longitudinal fasciculus, inferior fronto-occipital fasciculus, thalamus and anterior thalamic radiation, cerebral peduncle, and midbrain. Conclusions: Fatigue is associated to a widespread microstructural NAWM damage, particularly in associative tracts connected to frontal lobes.
Clinical phenotypes in adult patients with bronchiectasis
Authors: Aliberti Stefano , Lonni Sara , Dore Simone , McDonnell Melissa J. , Goeminne Pieter C. , Dimakou Katerina , Fardon Thomas C. , Rutherford Robert , Pesci Alberto , Restrepo Marcos I. , Sotgiu Giovanni , Chalmers James D. 
Published: February 2016

Bronchiectasis is a heterogeneous disease. This study aimed at identifying discrete groups of patients with different clinical and biological characteristics and long-term outcomes.This was a secondary analysis of five European databases of prospectively enrolled adult outpatients with bronchiectasis. Principal component and cluster analyses were performed using demographics, comorbidities, and clinical, radiological, functional and microbiological variables collected during the stable state. Exacerbations, hospitalisations and mortality during a 3-year follow-up were recorded. Clusters were externally validated in an independent cohort of patients with bronchiectasis, also investigating inflammatory markers in sputum.Among 1145 patients (median age 66 years; 40% male), four clusters were identified driven by the presence of chronic infection withPseudomonas aeruginosaor other pathogens and daily sputum: “Pseudomonas” (16%), “Other chronic infection” (24%), “Daily sputum” (33%) and “Dry bronchiectasis” (27%). Patients in the four clusters showed significant differences in terms of quality of life, exacerbations, hospitalisations and mortality during follow-up. In the validation cohort, free neutrophil elastase activity, myeloperoxidase activity and interleukin-1β levels in sputum were significantly different among the clusters.Identification of four clinical phenotypes in bronchiectasis could favour focused treatments in future interventional studies designed to alter the natural history of the disease.
RETRACTED ARTICLE: miR-320a affects spinal cord edema through negatively regulating aquaporin-1 of blood–spinal cord barrier during bimodal stage after ischemia reperfusion injury in rats
Authors: Li Xiao-Qian , Fang Bo , Tan Wen-Fei , Wang Zhi-Lin , Sun Xi-Jia , Zhang Zai-Li , Ma Hong 
Published: February 2016

AbstractBackgroundSpinal cord edema is a serious complication and pathophysiological change after ischemia reperfusion (IR) injury. It has been demonstrated closely associated with bimodal disruption of blood–spinal cord barrier (BSCB) in our previous work. Aquaporin (AQP)1 plays important but contradictory roles in water homeostasis. Recently, microRNAs (miRs) effectively regulate numerous target mRNAs during ischemia. However, whether miRs are able to protect against dimodal disruption of BSCB by regulating perivascular AQP1remains to be elucidated.ResultsSpinal water content and EB extravasation were suggested as a bimodal distribution in directly proportion to AQP1, since all maximal changes were detected at 12 and 48 h after reperfusion. Further TEM and double immunofluorescence showed that former disruption of BSCB at 12 h was attributed to cytotoxic edema by up-regulated AQP1expressions in astrocytes, whereas the latter at 48 h was mixed with vasogenic edema with both endothelial cells and astrocytes involvement. Microarray analysis revealed that at 12 h post-injury, ten miRs were upregulated (>2.0 fold) and seven miRs were downregulated (<0.5 fold) and at 48 h, ten miRs were upregulated and eleven were downregulated compared to Sham-operated controls. Genomic screening and luciferase assays identified that miR-320a was a potential modulator of AQP1in spinal cord after IR in vitro. In vivo, compared to rats in IR and negative control group, intrathecal infusion of miR-320a mimic attenuated IR-induced lower limb motor function deficits and BSCB dysfunction as decreased EB extravasation and spinal water content through down-regulating AQP1expressions, whereas pretreated with miR-320a AMO reversed above effects.ConclusionThese findings indicate miR-320a directly and functionally affects spinal cord edema through negatively regulating AQP1of BSCB after IR.
Roles of Estrogen Receptor-α and the Coactivator MED1 During Human Endometrial Decidualization
Authors: Kaya Okur Hatice S. , Das Amrita , Taylor Robert N. , Bagchi Indrani C. , Bagchi Milan K. 
Published: February 2016

AbstractThe steroid hormones 17β-estradiol and progesterone are critical regulators of endometrial stromal cell differentiation, known as decidualization, which is a prerequisite for successful establishment of pregnancy. The present study using primary human endometrial stromal cells (HESCs) addressed the role of estrogen receptor-α (ESR1) in decidualization. Knockdown of ESR1 transcripts by RNA interference led to a marked reduction in decidualization of HESCs. Gene expression profiling at an early stage of decidualization indicated that ESR1 negatively regulates several cell cycle regulatory factors, thereby suppressing the proliferation of HESCs as these cells enter the differentiation program. ESR1 also controls the expression of WNT4, FOXO1, and progesterone receptor (PGR), well-known mediators of decidualization. Whereas ESR1 knockdown strongly inhibited the expression of FOXO1 and WNT4 transcripts within 24 hours of the initiation of decidualization, PGR expression remained unaffected at this early time point. Our study also revealed a major role of cAMP signaling in influencing the function of ESR1 during decidualization. Using a proteomic approach, we discovered that the cAMP-dependent protein kinase A (PKA) phosphorylates Mediator 1 (MED1), a subunit of the mediator coactivator complex, during HESC differentiation. Using immunoprecipitation, we demonstrated that PKA-phosphorylated MED1 interacts with ESR1. The PKA-dependent phosphorylation of MED1 was also correlated with its enhanced recruitment to estrogen-responsive elements in the WNT4 gene. Knockdown of MED1 transcripts impaired the expression of ESR1-induced WNT4 and FOXO1 transcripts and blocked decidualization. Based on these findings, we conclude that modulation of ESR1-MED1 interactions by cAMP signaling plays a critical role in human decidualization.
Current recommendations for assessing the reliability of a measurement tool
Authors: Langlois J. , Hamadouche M. 
Published: February 2016

Previous standards for assessing the reliability of a measurement tool have lacked consistency. We reviewed the most current American Society for Testing and Materials and International Organisation for Standardisation (ISO) recommendations, and propose an algorithm for orthopaedic surgeons. When assessing a measurement tool, conditions of the experimental set-up and clear formulae used to compile the results should be strictly reported. According to these recent guidelines, accuracy is a confusing word with an overly broad meaning and should therefore be abandoned. Depending on the experimental conditions, one should be referring to bias (when the study protocol involves accepted reference values), and repeatability (sr, r) or reproducibility (SR, R). In the absence of accepted reference values, only repeatability (sr, r) or reproducibility (SR, R) should be provided. Take home message: Assessing the reliability of a measurement tool involves reporting bias, repeatability and/or reproducibility depending on the defined conditions, instead of precision or accuracy. Cite this article: Bone Joint J 2016;98-B2:166–72.
Restoration of the spinal canal volume in stenosis dependent on pedicle-lengthening distance in pedicle-lengthening osteotomy
Authors: Qian L. , Li P. , Wu W. , Fang Y. , Zhang J. , Ouyang J. 
Published: February 2016

Aims This study aimed to determine the relationship between pedicle-lengthening distance and bulge-canal volume ratio in cases of lumbar spinal stenosis, to provide a theoretical basis for the extent of lengthening in pedicle-lengthening osteotomies. Methods Three-dimensional reconstructions of CT images were performed for 69 patients (33 men and 36 women) (mean age 49.96 years; 24 to 81). Simulated pedicle-lengthening osteotomies and disc bulge and spinal canal volume calculations were performed using Mimics software. Results The mean spinal canal volume of the two groups, L4 and L5, were 14 646.81 mm3 (5918.60 to 22 717.77) and 16 408.47 mm3 (8678.21 to 31 204.79), respectively. The mean lengthening distance was 2.17 mm (0.5 to 4.8) and the mean bulge-canal volume ratio was 0.23 (0.05 to 0.48). The pedicle-lengthening distance of the two groups were very strongly correlated with disc bulge volume and bulge-canal volume ratio (p < 0.001); the predictive equation was established as L = 0.06 + 9.06R (where L equals the pedicle-lengthening distance and R represents the bulge-canal volume ratio). Discussion Our findings indicated that lumbar pedicle-lengthening distance strongly correlates with bulge-canal volume ratio, which can be estimated before surgery from CT images. Take home message: The predictive equation could help surgeons to decide the pedicle lengthening distance according to individual's condition and guide the surgery effectively. Cite this article: Bone Joint J 2016;98-B:238–43.
Predictors of outcome after single-event multilevel surgery in children with cerebral palsy
Authors: Švehlík M. , Steinwender G. , Lehmann T. , Kraus T. 
Published: February 2016

Aims Single event multilevel surgery (SEMLS) has been shown to improve gait in children with cerebral palsy (CP). However, there is limited evidence regarding long-term outcomes and factors influencing them. Methods In total 39 children (17 females and 22 males; mean age at SEMLS ten years four months, standard deviation 37 months) with bilateral CP (20 Gross Motor Function Classification System (GMFCS) level II and 19 GMFCS level III) treated with SEMLS were included. Children were evaluated using gait analysis and the Gait Deviation Index (GDI) before SEMLS and one, two to three, five and at least ten years after SEMLS. A linear mixed model was used to estimate the effect of age at the surgery, GMFCS and follow-up period on GDI. Results There was a mean improvement of 12.1 (-15.3 to 45.1) GDI points one year after SEMLS (p < 0.001) and 10.3 (-23.1 to 44.2) GDI points ten years after SEMLS compared with before SEMLS (p < 0.001). GMFCS level III children aged ten to 12 years had the most improvement. The GMFCS III group had more surgical procedures at the index SEMLS (p < 0.001) and during the follow-up period (p = 0.039). After correcting for other factors, age at surgery was the only factor predictive of long-term results. Our model was able to explain 45% of the variance of the change in GDI at the different time points. Take home message: Children with GMFCS III level aged ten to 12 are the benchmark responders to SEMLS in the long-term. Cite this article: Bone Joint J 2016;98-B:278–81.
Delayed dislocation following metal-on-polyethylene arthroplasty of the hip due to ‘silent’ trunnion corrosion
Authors: Lash N. J. , Whitehouse M. R. , Greidanus N. V. , Garbuz D. S. , Masri B. A. , Duncan C. P. 
Published: February 2016

AimsWe present a case series of ten metal-on-polyethylene total hip arthroplasties (MoP THAs) with delayed dislocation associated with unrecognised adverse local tissue reaction due to corrosion at the trunnion and pseudotumour formation.MethodsThe diagnosis was not suspected in nine of the ten patients (six female/four male; mean age 66 years), despite treatment in a specialist unit (mean time from index surgery to revision was 58 months, 36 to 84). It was identified at revision surgery and subsequently confirmed by histological examination of resected tissue. Pre-operative assessment and culture results ruled out infection. A variety of treatment strategies were used, including resection of the pseudotumour and efforts to avoid recurrent dislocation.ResultsThe rate of complications was high and included three deep infections, two patients with recurrent dislocation, and one recurrent pseudotumour.ConclusionThis series (mean follow-up of 76 months following index procedure and 19 months following revision THA) demonstrates that pseudotumour is an infrequent but important contributor to delayed instability following MoP THA. It is easy to overlook in the differential diagnosis, especially if the alignment of the components is less than optimal, leading to an assumption that malalignment is the cause of the dislocation. The instability is likely to be multifactorial and the revision surgery is complex. Take home message: Due to the high complication rate associated with revision in this cohort, the diagnosis should be borne in mind when counselling patients regarding the risks of revision surgery. Cite this article: Bone Joint J 2016;98-B:187–93.