bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of Risk Stratification in Localized Prostate Cancer
Authors: Morgans Alicia Katherine 
Published: January 2018

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. A 67-year-old retired engineering professor was found to have a prostate-specific antigen (PSA) level of 11 ng/mL on a screening test at his annual physical examination. A digital rectal examination revealed a nodule on the right side. He underwent a transrectal ultrasound-guided prostate biopsy that was notable for prostate adenocarcinoma, Gleason 3 + 4 = 7 (Gleason grade group 2; 30% Gleason 4 component) involving two cores (60% and 20% core involvement). A bone scan and pelvic computed tomography scan were negative for evidence of metastatic disease. (Should he undergo prostate magnetic resonance imaging? That seems rather common these days.) He was diagnosed with cT2b intermediate-risk localized prostate cancer (PCa) by National Comprehensive Cancer Network (NCCN) risk group and was seen in the multidisciplinary clinic to discuss management options (Table 1).
Clinical Diabetes Centers of Excellence: A Model for Future Adult Diabetes Care
Authors: Draznin Boris , Kahn Peter A , Wagner Nicole , Hirsch Irl B , Korytkowski Mary , Harlan David M , McDonnell Marie E , Gabbay Robert A 
Published: January 2018

Abstract
Although diabetes research centers are well defined by National Institutes of Health, there is no clear definition for clinical Diabetes Centers of Excellence (DCOEs). There are multiple clinical diabetes centers across the United States, some established with philanthropic funding; however, it is not clear what defines a DCOE from a clinical perspective and what the future will be for these centers. In this Perspective we propose a framework to guide advancement for DCOEs. With the shift toward value-based purchasing and reimbursement and away from fee for service, defining the procedures for broader implementation of DCOEs as a way to improve population health and patient care experience (including quality and satisfaction) and reduce health care costs becomes critically important. It is prudent to implement new financial systems for compensating diabetes care that may not be provided by fiscally constrained private and academic medical centers. We envision that future clinical DCOEs would be composed of a well-defined infrastructure and six domains or pillars serving as the general guiding principles for developing expertise in diabetes care that can be readily demonstrated to stakeholders, including health care providers, patients, payers, and government agencies.
Restricted cell functions on micropillars are alleviated by surface-nanocoating with amino groups
Authors: Moerke Caroline , Staehlke Susanne , Rebl Henrike , Finke Birgit , Nebe J. Barbara 
Published: January 2018

ABSTRACT
The topographical and chemical surface features of biomaterials are sensed by the cells, affecting their physiology at the interface. When placed on titanium, we recently discovered osteoblasts attempted caveolae-mediated phagocytosis of the sharp-edged microstructures. This active, energy-consuming process resulted in decreased osteoblastic cell functions (e.g. secretion of extracellular matrix proteins). However, chemical modification with plasma polymerized allylamine (PPAAm) was able to amplify osteoblast adhesion and spreading, resulting in better implant osseointegration in vivo. In the present in vitro study, we analyzed whether this plasma polymer nanocoating is able to attenuate the microtopography-induced changes of osteoblast physiology. On PPAAm, we found cells showed a higher cell interaction with the geometrical micropillars by 30 min, and a less distinct reduction in the mRNA expression of collagen type I, osteocalcin and fibronectin after 24 h of cell growth. Interestingly, the cells were more active and sensitive on PPAAm-coated micropillars, and react with a substantial Ca2+ ion mobilization after stimulation with ATP. These results highlight that it is important for osteoblasts to establish cell surface contact for them to perform their functions.
Nitroimidazoles as hypoxic cell radiosensitizers and hypoxia probes: misonidazole, myths and mistakes
Authors: Wardman Peter 
Published: January 2018

Nitroimidazoles have been extensively explored as hypoxic cell radiosensitizers but have had limited clinical success, with efficacy restricted by toxicity. However, they have proven clinically useful as probes for tumour hypoxia. Both applications, and probably much of the dose-limiting toxicities, reflect the dominant chemical property of electron affinity or ease of reduction, associated with the nitro substituent in an aromatic structure. This single dominant property affords unusual, indeed extraordinary flexibility in drug or probe design, suggesting further development is possible in spite of earlier limitations, in particular building on the benefit of hindsight and an appreciation of errors made in earlier studies. The most notable errors were: the delay in viewing cellular thiol depletion as a likely common artefact in testing in vitro; slow recognition of pH-driven concentration gradients when compounds were weak acids and bases; and a failure to explore the possible involvement of pH and ascorbate in influencing hypoxia probe binding. The experience points to the need to involve a wider range of expertise than that historically involved in many laboratories when studying the effects of chemicals on radiation response or using diagnostic probes.
Fractures of the femoral shaft in children
Authors: Talbot C. , Davis N. , Majid I. , Young M. , Bouamra O. , Lecky F. E. , Jones S. 
Published: January 2018

AimsThe aim of this study was to describe the epidemiology of closed isolated fractures of the femoral shaft in children, and to compare the treatment and length of stay (LOS) between major trauma centres (MTCs) and trauma units (TUs) in England.Patients and MethodsNational data were obtained from the Trauma and Audit Research Network for all isolated, closed fractures of the femoral shaft in children from birth to 15 years of age, between 2012 and 2015. Age, gender, the season in which the fracture occurred, non-accidental injury, the mechanism of injury, hospital trauma status, LOS and type of treatment were recorded.ResultsA total of 1852 fractures were identified. The mean annual incidence was 5.82 per 100 000 children (95% confidence interval (CI) 5.20 to 6.44). The age of peak incidence was two years for both boys and girls; this decreased with increasing age. Children aged four to six years treated in MTCs were more likely to be managed with open reduction and internal fixation compared with those treated in TUs (odds ratio 3.20; 95% CI 1.12 to 9.14; p = 0.03). The median LOS was significantly less in MTCs than in TUs for children aged between 18 months and three years treated in both a spica (p = 0.005) and traction (p = 0.0004).ConclusionThis study highlights the current national trends in the management of closed isolated fractures of the femoral shaft in children following activation of major trauma networks in 2012. Future studies focusing on the reasons for the differences which have been identified may help to achieve more consistency in the management of these injuries across the trauma networks. Cite this article: Bone Joint J 2018;100-B:109–18.
Outcomes of dual mobility components in total hip arthroplasty
Authors: Darrith B. , Courtney P. M. , Della Valle C. J. 
Published: January 2018

Aims Instability remains a challenging problem in both primary and revision total hip arthroplasty (THA). Dual mobility components confer increased stability, but there are concerns about the unique complications associated with these designs, as well as the long-term survivorship. Materials and Methods We performed a systematic review of all English language articles dealing with dual mobility THAs published between 2007 and 2016 in the MEDLINE and Embase electronic databases. A total of 54 articles met inclusion criteria for the final analysis of primary and revision dual mobility THAs and dual mobility THAs used in the treatment of fractures of the femoral neck. We analysed the survivorship and rates of aseptic loosening and of intraprosthetic and extra-articular dislocation. Results For the 10 783 primary dual mobility THAs, the incidence of aseptic loosening was 1.3% (142 hips); the rate of intraprosthetic dislocation was 1.1% (122 hips) and the incidence of extra-articular dislocation was 0.46% (41 hips). The overall survivorship of the acetabular component and the dual mobility components was 98.0%, with all-cause revision as the endpoint at a mean follow-up of 8.5 years (2 to 16.5). For the 3008 revision dual mobility THAs, the rate of aseptic acetabular loosening was 1.4% (29 hips); the rate of intraprosthetic dislocation was 0.3% (eight hips) and the rate of extra-articular dislocation was 2.2% (67 hips). The survivorship of the acatabular and dual mobility components was 96.6% at a mean of 5.4 years (2 to 8). For the 554 dual mobility THAs which were undertaken in patients with a fracture of the femoral neck, the rate of intraprosthetic dislocation was 0.18% (one hip), the rate of extra-articular dislocation was 2.3% (13 hips) and there was one aseptic loosening. The survivorship was 97.8% at a mean of 1.3 years (0.75 to 2). Conclusion Dual mobility articulations are a viable alternative to traditional bearing surfaces, with low rates of instability and good overall survivorship in primary and revision THAs, and in those undertaken in patients with a fracture of the femoral neck. The incidence of intraprosthetic dislocation is low and limited mainly to earlier designs. High-quality, prospective, comparative studies are needed to evaluate further the use of dual mobility components in THA. Cite this article: Bone Joint J 2018;100-B:11–19.
Efficacy and adverse effects of collagenase use in the treatment of Dupuytren’s disease
Authors: Sanjuan-Cerveró R. , Carrera-Hueso F. J. , Vazquez-Ferreiro P. , Ramon-Barrios M. A. 
Published: January 2018

Aims The aim of this meta-analysis was to assess the safety and efficacy of collagenase clostridium histolyticum compared with fasciectomy and percutaneous needle fasciotomy (PNF) for Dupuytren’s disease. Materials and Methods We systematically searched PubMed, EMBASE, LILACS, Web of Science, Cochrane, Teseo and the ClinicalTrials.gov registry for clinical trials and cohort or case-control studies which compared the clinical outcomes and adverse effects of collagenase with those of fasciectomy or PNF. Of 1345 articles retrieved, ten were selected. They described the outcomes of 425 patients treated with collagenase and 418 treated by fasciectomy or PNF. Complications were assessed using inverse-variance weighted odds ratios (ORs). Clinical efficacy was assessed by differences between the means for movement of the joint before and after treatment. Dose adjustment was applied in all cases. Results Random-effects modelling showed that patients treated with collagenase had 3.24 increased odds of adverse effects compared with those treated by fasciectomy (OR 4.39) or PNF (OR 1.72,). The effect was lost when only major complications were assessed. Joint movement analysis revealed a difference between means of less than 10%, indicating equivalent clinical efficacy in the short and medium term for collagenase and fasciectomy. We were unable to analyse this for PNF due to a shortage of data. Conclusion There were no significant differences in effect size between collagenase and fasciectomy. The use of collagenase was associated with a higher overall risk of adverse effects than both fasciectomy and PNF. Cite this article: Bone Joint J 2018;100-B:73–80.
The risk of cardiac failure following metal-on-metal hip arthroplasty
Authors: Sabah S. A. , Moon J. C. , Jenkins-Jones S. , Morgan C. Ll. , Currie C. J. , Wilkinson J. M. , Porter M. , Captur G. , Henckel J. , Chaturvedi N. , Kay P. , Skinner J. A. , Hart A. H. , Manisty C. 
Published: January 2018

Aims The aim of this study was to determine whether patients with metal-on-metal (MoM) arthroplasties of the hip have an increased risk of cardiac failure compared with those with alternative types of arthroplasties (non-MoM). Patients and Methods A linkage study between the National Joint Registry, Hospital Episodes Statistics and records of the Office for National Statistics on deaths was undertaken. Patients who underwent elective total hip arthroplasty between January 2003 and December 2014 with no past history of cardiac failure were included and stratified as having either a MoM (n = 53 529) or a non-MoM (n = 482 247) arthroplasty. The primary outcome measure was the time to an admission to hospital for cardiac failure or death. Analysis was carried out using data from all patients and from those matched by propensity score. Results The risk of cardiac failure was lower in the MoM cohort compared with the non-MoM cohort (adjusted hazard ratio (aHR) 0.901; 95% confidence interval (CI) 0.853 to 0.953). The risk of cardiac failure was similar following matching (aHR 0.909; 95% CI 0.838 to 0.987) and the findings were consistent in subgroup analysis. Conclusion The risk of cardiac failure following total hip arthroplasty was not increased in those in whom MoM implants were used, compared with those in whom other types of prostheses were used, in the first seven years after surgery. Cite this article: Bone Joint J 2018;100-B:20–7.
Upper arm fat and muscle in stunted and non-stunted children aged 0-24 months
Authors: Arundito Bagus Winandi , Julia Madarina , Nurani Neti , Prawirohartono Endy Paryanto 
Published: January 2018

Background The prevalence of stunting in Indonesia is high, with particularly negative impacts on health during childhood as well as adolescence. Stunting impacts the health of children as well as adults, especially with regards to future obesity. Therefore, evaluating body composition of stunted children before 2 years of age is necessary.Objective To compare upper arm fat and muscle measurements in stunted and non-stunted children aged 0-24 months of age.Methods We analyzed secondary data of the Division of Nutrition and Metabolic Disease, Department of Child Health, Universitas Gadjah Mada Medical School, Yogyakarta which were collected using cluster random sampling from the Yogyakarta Special Province. We compared upper arm fat area (UFA), including the upper arm fat area estimate (UFE) and the upper arm fat percentage (UFP), as well as upper arm muscle area (UMA) and upper arm muscle area estimate (UME), among stunted and non-stunted children aged 0-24 months.Results We analyzed 2,195 children. The prevalence of stunting was 354/2,195 (16.1%). The UFA, UFE, and UFP among stunted children were significantly lower compared to non-stunted children aged 7-12 months [UFA: 4.48 vs. 5.05 cm2 (P <0.001), respectively; UFE: 4.88 vs. 5.55 cm2 (P <0.001), respectively; and UFP: 30.82 vs. 32.58% (P = 0.03), respectively]. The UMA in children aged 7-12 months was also significantly lower in stunted than in non-stunted children [11.31 vs. 11.79 cm2 (P = 0.02), respectively], as well as in children aged 13-24 months [11.05 vs. 11.75 cm2 (P <0.001), respectively]. In addition, the UME in children aged 13-24 months was significantly lower in stunted compared to non-stunted children [10.50 vs. 11.18 cm2 (P <0.001), respectively].Conclusion The UFA in children aged 7-12 months is smaller in stunted than in non-stunted children, whereas UMA in children aged 7-12 months and 13-24 months was smaller in stunted compared to non-stunted children.
Queer Crossings: Kinship, Marriage, and Sexuality in Igboland and Carriacou
Authors: Apter Andrew 
Published: January 2018

Abstract
In this article, I problematize the historical development of quasi-institutionalized lesbianism on the Caribbean island of Carriacou, addressing veiled references to its “Igbo” origins in popular music and culture. How do we interpret such muted intimations and the forms of historicity they suggest? I argue that a case for Igbo origins can be made if we separate gender from sexuality. Reading Ifi Amadiume and Nwando Achebe on “female husbands” in Igboland in relation to M. G. Smith’s documentation of lesbianism in Carriacou, I identify related logics of lineage organization, prostitution, and property devolution linking both cases to “queer” conjugal forms. But whereas such unions were eroticized in Carriacou, in West Africa they remained strictly jural. That an Igbo form of woman-to- woman marriage was sexualized in Carriacou shows how flexible West African gender ideologies shaped queer sexualities under radically different historical conditions than in the Americas.
Pythagorean Hesitant Fuzzy Information Aggregation and Their Application to Multi-Attribute Group Decision-Making Problems
Authors: Khan Muhammad Sajjad Ali , Abdullah Saleem , Ali Asad , Rahman Khaista 
Published: January 2018

Abstract
In this paper, we introduce the concept of the Pythagorean hesitant fuzzy set (PHFS), which is the generalization of the intuitionistic hesitant fuzzy set under the restriction that the square sum of its membership degrees is ≤1. In decision making with PHFSs, aggregation operators play a key role because they can be used to synthesize multidimensional evaluation values represented as Pythagorean hesitant fuzzy values into collective values. Under PHFS environments, Pythagorean hesitant fuzzy ordered weighted averaging and Pythagorean fuzzy ordered weighted geometric operators are used to aggregate the Pythagorean hesitant fuzzy values. The main advantage of these operators is that they provide more accurate and valuable results. Furthermore, these operators are applied to decision-making problems in which experts provide their preferences in the Pythagorean hesitant fuzzy environment to show the validity, practicality, and effectiveness of the new approach. Finally, we compare the proposed approach to the existing methods.
Characterization of calmodulin in the clam Anodonta woodiana: differential expressions in response to environmental Ca2+ and Cd2+
Authors: Xia Xichao , Liang Guina , Zheng Xinhua , Wang Fuan , Zhang Junfeng , Xue Shipeng , Hua Chuanxiu , Song Guoying , Bai Xianguang , Guo Lianghong 
Published: January 2018

Abstract

Aims
To explore effect of Ca2+ and Cd2+ on the calmodulin (CaM), one complete cDNA sequence (AwCaM1) was cloned and characterized from the freshwater mussel Anodonta woodiana and its expressions were analyzed.

Materials and methods
The AwCaM1 was cloned from the A. woodiana using the rapid amplification of cDNA ends methods and its expression was determined by real-time PCR.

Results
In the hepatopancreas, AwCaM1 expression was up-regulated with a time and dose dependent pattern in the Ca2+ treated groups (0.01, 0.02, 0.04 and 0.08 mg/L) during experiment observed, and increased more than 56.15% (p<0.05) compared with that of control group. AwCaM1 mRNA level increased more 65.04% (p<0.05) in the Cd2+ treated groups (8 and 16 mg/L). In the gill, AwCaM1 expression increased more than 79.41% (p<0.05) compared with that of control group in all the Ca2+ treated groups, and more than 88.23% (p<0.05) in all the Cd2+ treated groups.

Conclusion
These results indicated that up-regulations of AwCaM1 expression in bivalve A. woodiana are associated with Ca2+ absorb and environmental adaption derived from Ca2+ and Cd2+ treatment.
Spelling out enclitics and giving their tone a voice: Cyclic clitic incorporation in BCS and breaking the cycle
Authors: Talić Aida 
Published: January 2018

AbstractThis paper examines previously unnoticed facts about prosodic interactions between enclitics and their hosts in Bosnian/Croatian/Serbian (BCS). I show that there is a three-way split between BCS enclitics in this respect: (i) enclitics that always interact with the accent of their host; (ii) enclitics that interact with the accent of their host in some contexts, but not in others; (iii) and enclitics that never interact with the accent of their host. It is shown that this rather complex pattern can be accounted for in its entirety by a condition on prosodic incorporation of enclitics that holds at the point when syntactic structure is mapped to prosodic structure, which essentially requires the clitic and the host to be in the same spell-out domain in order for the clitic to incorporate into the prosodic word of its host, a prerequisite for the clitic to interact with the accent of its host. I also discuss certain idiosyncratic phonological properties of the auxiliary cliticje‘be.3sg’ and the particlese‘self’ that cause reordering of enclitics in PF. It is shown that this PF movement can have an effect on whether a clitic is spelled out in the same domain as its host, which in turn affects the prosodic interaction between the two. Based on the prosodic interaction of enclitics with the accent of their host, I argue for a phase-based approach to prosodic structure building (see also Dobashi 2003; Kahnemuyipour 2004, 2009;Kratzer and Selkirk 2007; Sato 2012; Sato and Dobashi 2016; among others).
Maintenance of efficacy after duodenal– jejunal bypass liner explantation in the first NHS EndoBarrier service
Authors: Ryder Robert EJ , Yadagiri Mahi , Irwin Susan P , Burbridge Wyn , Gandhi Hardeep , Allden Rachael A , Bleasdale John P , Fogden Edward N , Anderson Mark R , Gupta Piya Sen 
Published: January 2018

EndoBarrier®, a 60 cm endoscopically implanted proximal intestinal liner, reduces weight and HbA1c over 1 year. We report the outcomes of the first 12 patients who completed 6 months post EndoBarrier removal in the first NHS EndoBarrier service. All patients were obese (body mass index 41.7±9.8 kg/m2) with diabetes for 10–25 years and 75% were on insulin therapy. All patients (age 52.4±9.3 years) were advised to institute behavioural changes during the implant period (1 year) and maintain them thereafter. Implantation of EndoBarrier for 1 year reduced weight (17.6±8.9 kg, p<0.001), HbA1c (26.7±20.8 mmol/mol, 2.4±1.9%, p=0.001), systolic blood pressure (14.1±16.1 mmHg, p=0.011) and median total daily insulin dose from 104 to 48 Units/day (p=0.024) (n=9). Six months post EndoBarrier removal, 75% of patients sustained the metabolic improvement achieved with EndoBarrier; insulin dose requirement continued to fall and four of the nine insulin-treated patients discontinued insulin. Of the three patients whose weight/glycaemic control worsened, two had depression and one became immobile after explantation due to ill health unrelated to EndoBarrier treatment. Most (93.8%) of our patients stated that they would be extremely likely to recommend our service to friends and family. These data are encouraging for wider establishment of NHS EndoBarrier services.