bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflexible versus flexible: the influence of temperature and photoperiod on pre‐ and post‐eyespot development time in Libellulidae (Odonata)
Authors: Hesse Lisa , Falk Joachim , Koch Kamilla 
Published: May 2016

AbstractTemperature and photoperiod are important environmental parameters for organisms. The present study tests the hypothesis that, during embryogenesis, temperature and photoperiod influence pre‐ and post‐eyespot development time in dragonflies of the family Libellulidae differently. Eggs are used from eight species (five different genera, from Africa/Europe, and lentic/lotic habitat preferences). The eggs are reared under different constant or fluctuating temperature and light conditions. There are no general species‐specific degree‐days for pre‐ or the post‐eyespot development in these species. In all study species, the variance within and between the treatments of the duration in days and the degree‐days of pre‐eyespot development is lower than that of post‐eyespot development. Pre‐eyespot development appears to be less flexible in its reaction to environmental influences. By contrast, post‐eyespot development appears to react more flexibly to environmental influences. All eight species show the same pattern. This indicates strongly that this flexibility is a general pattern in Libellulidae that might help the species within this family to cope successfully with variations in environmental conditions. Because eyespot development and katatrepsis occur close to each other, the above‐described pattern might also appear in other odonates and in other insect groups that exhibit katatrepsis. For all of them, it is essential for survival to match the time of hatching with adequate external temperature and photoperiodic conditions.
Strategies for new and improved vaccines against ticks and tick‐borne diseases
Authors: de la Fuente J. , Kopáček P. , Lew‐Tabor A. , Maritz‐Olivier C. 
Published: May 2016

SummaryTicks infest a variety of animal species and transmit pathogens causing disease in both humans and animals worldwide. Tick–host–pathogen interactions have evolved through dynamic processes that accommodated the genetic traits of the hosts, pathogens transmitted and the vector tick species that mediate their development and survival. New approaches for tick control are dependent on defining molecular interactions between hosts, ticks and pathogens to allow for discovery of key molecules that could be tested in vaccines or new generation therapeutics for intervention of tick–pathogen cycles. Currently, tick vaccines constitute an effective and environmentally sound approach for the control of ticks and the transmission of the associated tick‐borne diseases. New candidate protective antigens will most likely be identified by focusing on proteins with relevant biological function in the feeding, reproduction, development, immune response, subversion of host immunity of the tick vector and/or molecules vital for pathogen infection and transmission. This review addresses different approaches and strategies used for the discovery of protective antigens, including focusing on relevant tick biological functions and proteins, reverse genetics, vaccinomics and tick protein evolution and interactomics. New and improved tick vaccines will most likely contain multiple antigens to control tick infestations and pathogen infection and transmission.
Affect and Taste: Bourdieu, Traditional Music, and the Performance of Possibilities
Authors: Ashwood Loka , Bell Michael M. 
Published: May 2016

AbstractIn his famousDistinction, Bourdieu set forth musical and artistic taste as reflections of class positions developed early in life. With classical music as an explanatory tool, Bourdieu argued that cultural capital becomes deeply embodied and difficult to change. In temperance of Bourdieu's use of class, we suggest an affective theory of taste through the case of traditional music, based on a performance of possibilities inspired by our experiences in two pubs, one English and one Irish. Commonly played in pubs, traditional music can draw on rural lore to share its message with singing patrons of mixed class backgrounds. We use traditional music to argue that place shapes diverse social ties at all levels of economics, education, and age. We do not dispute that class powerfully shapes taste. But through what we term the joy of transcendence – formed through distinct and relative experiences, bonds, and friendships, enacted through place – participants can find pleasure in opening the cages of class and connecting across difference.
Optimal Stopping Location of a High Speed Train using GIS and Multicriteria Decision‐making
Authors: Sañudo Roberto , Luis Moura Jose , Cordera Ruben , Ibeas Angel 
Published: May 2016

AbstractThis article develops a methodology using a Geographical Information System (GIS) to evaluate the best location to stop a high speed passenger train when faced with an undesired event. The proposed method is based on multicriteria decision‐making where different stretches of line which could be chosen as the stopping point are ranked depending on the characteristics of the line, the surrounding area and its accessibility for equipment. The method was integrated into the GIS to develop an expert support system for decision makers faced with different kinds of undesired events. It has been applied to a case study on the high speed line between Valladolid and Madrid (Spain). The proposed method is new and has not previously been applied to high speed railway networks and could be adapted to other case studies. The speed of the algorithm provides an almost instantaneous reply within seconds of an emergency situation occurring. The method can therefore be part of an overall support system for decision making in undesired rail events.
Microvasculature of the California sea lion (Zalophus californianus) eye and its functional significance
Authors: Ninomiya Hiroyoshi 
Published: May 2016

AbstractObjectiveTo examine the ocular circulation in California sea lions (Zalophus californianus).Animals studiedEyes were obtained postmortem from three sea lions that died while in captivity.ProceduresSpecimens from sea lions were investigated using scanning electron microscopy (SEM) of vascular corrosion casts. The thermal characteristics of live animal eyes were measured using an infrared imaging system.ResultsThe major orbital artery of the sea lion was the ophthalmic artery. The artery was remarkably thick in diameter, showed a marked convolution and formed an ophthalmic rete around the optic nerve at the posterior pole of the eyeball. The long posterior ciliary artery terminates to form a prominent inner arterial circle at the pupillary margin. The iridial arteries originated from the arterial circle showing either a crimped or somewhat coiled course, extending toward the root of the iris and formed a root supplying a large amount of blood to the iris and ciliary bodies. The venules in the conjunctiva formed a well‐developed venous plexus. The vortex veins showed a dilation and constriction at the site passing through the sclera. Thermographic examination revealed that the eye showed a higher degree of thermal emission than adjacent skin areas.ConclusionsThese characteristics suggest that the ocular vasculature might play roles in thermoregulation as well as in hemodynamics by draining a large amount of blood so that the appropriate operating temperature for the eye can be maintained in a deep and cold aquatic environment.
Farm‐scale evaluation of herbicide band application integrated with inter‐row mechanical weeding for maize production in four European regions
Authors: Vasileiadis V P , van Dijk W , Verschwele A , Holb I J , Vámos A , Urek G , Leskovšek R , Furlan L , Sattin M 
Published: May 2016

SummaryTo promote integrated weed management (IWM) implementation in Europe, robust evidence on the sustainability of such tools and strategies is needed to motivate their adoption by stakeholders. This can only be achieved through assessing and validating them at real farm scale and using existing farm equipment, under diverse climatic and soil conditions representative of European agriculture. In 2013 and 2014, 12 on‐farm experiments (i.e. real field conditions on commercial farms, with natural weed flora) were conducted in four important European grain maize‐producing regions comparing the efficacy of herbicide band application integrated with inter‐row mechanical weeding as a potential IWM tool with the conventional broadcast herbicide application (CON) used by the farms. The IWM tools tested were as follows: (i) early post‐emergence herbicide band application combined with hoeing, followed by a second hoeing in southern Germany, (ii) early post‐emergence herbicide band application followed by hoeing in eastern Hungary and central Slovenia and (iii) pre‐emergence herbicide band application followed by hoeing in northern Italy. Herbicide band application integrated with hoeing provided good and partial weed control along and between maize rows respectively. No significant yield differences were detected between IWM and CON. IWM greatly reduced herbicide input and was economically sustainable over the duration of this study with no significant difference in gross margin compared with CON in all cases. This IWM tool could therefore be considered for implementation in European maize systems.
A new method for skin grafting in murine model
Authors: Pakyari Mohammadreza , Farokhi Ali , Khosravi‐Maharlooei Mohsen , Kilani Ruhangiz T. , Ghahary Aziz , Brown Erin 
Published: May 2016

AbstractSkin transplantation provides an excellent potential model to investigate the immunology of allograft rejection and tolerance induction. Despite the theoretical ease of performing skin transplantation, as well as the potential of directly observing the reaction to the transplanted tissue, the poor reliability of skin transplantation in the mouse has largely precluded the use of this model. Furthermore, there is controversy regarding the most appropriate skin graft donor site due to poor success of back skin transplantation, as compared with the thinner ear or tail skin. This study demonstrates a reliable method to successfully perform skin grafts in a mouse model, as well as the clinical and histologic outcome of syngeneic grafts. A total of 287 grafts were performed (in 126 mice) utilizing donor skin from the ear, tail or back. No graft failure or postoperative mortality was observed. Comparison of this technique with two previously established protocols of skin transplantation (5.0 absorbable Suture + tissue glue technique and no‐suture technique) demonstrates the significant improvement in the engraftment success of the new technique. In summary, a new technique for murine skin grafting demonstrates improved reliability across donor site locations and strains, increasing the potential for investigating interventions to alter the rejection process.
Cellular and circuit mechanisms underlying spinocerebellar ataxias
Authors: Meera Pratap , Pulst Stefan M. , Otis Thomas S. 
Published: May 2016

AbstractDegenerative ataxias are a common form of neurodegenerative disease that affect about 20 individuals per 100,000. The autosomal dominant spinocerebellar ataxias (SCAs) are caused by a variety of protein coding mutations (single nucleotide changes, deletions and expansions) in single genes. Affected genes encode plasma membrane and intracellular ion channels, membrane receptors, protein kinases, protein phosphatases and proteins of unknown function. Although SCA‐linked genes are quite diverse they share two key features: first, they are highly, although not exclusively, expressed in cerebellar Purkinje neurons (PNs), and second, when mutated they lead ultimately to the degeneration of PNs. In this review we summarize ataxia‐related changes in PN neurophysiology that have been observed in various mouse knockout lines and in transgenic models of human SCA. We also highlight emerging evidence that altered metabotropic glutamate receptor signalling and disrupted calcium homeostasis in PNs form a common, early pathophysiological mechanism in SCAs. Together these findings indicate that aberrant calcium signalling and profound changes in PN neurophysiology precede PN cell loss and are likely to lead to cerebellar circuit dysfunction that explains behavioural signs of ataxia characteristic of the disease.
A Path-Based Distance for Street Map Comparison
Authors: Ahmed Mahmuda , Fasy Brittany Terese , Hickmann Kyle S. , Wenk Carola 
Published: May 2016

Comparing two geometric graphs embedded in space is important in the field of transportation network analysis. Given street maps of the same city collected from different sources, researchers often need to know how and where they differ. However, the majority of current graph comparison algorithms are based on structural properties of graphs, such as their degree distribution or their local connectivity properties, and do not consider their spatial embedding. This ignores a key property of road networks since the similarity of travel over two road networks is intimately tied to the specific spatial embedding. Likewise, many current algorithms specific to street map comparison either do not provide quality guarantees or focus on spatial embeddings only.
Motivated by road network comparison, we propose a new path-based distance measure between two planar geometric graphs that is based on comparing sets of travel paths generated over the graphs. Surprisingly, we are able to show that using paths of bounded link-length, we can capture global structural and spatial differences between the graphs.
We show how to utilize our distance measure as a local signature in order to identify and visualize portions of high similarity in the maps. Finally, we present an experimental evaluation of our distance measure and its local signature on street map data from Berlin, Germany and Athens, Greece.
Symbolic Trajectories
Authors: Güting Ralf Hartmut , Valdés Fabio , Damiani Maria Luisa 
Published: May 2016

Due to the proliferation of GPS-enabled devices in vehicles or with people, large amounts of position data are recorded every day and the management of such mobility data, also called trajectories, is a very active research field. A lot of effort has gone into discovering “semantics” from the raw geometric trajectories by relating them to the spatial environment or finding patterns, for example, by data mining techniques. A question is how the resulting “meaningful” trajectories can be represented or further queried.

In this article, we propose a systematic study of
annotated trajectory databases
. We define a very simple generic model called
symbolic trajectory
to capture a wide range of meanings derived from a geometric trajectory. Essentially, a symbolic trajectory is just a time-dependent label; variants have sets of labels, places, or sets of places. They are modeled as abstract data types and integrated into a well-established framework of data types and operations for moving objects. Symbolic trajectories can represent, for example, the names of roads traversed obtained by map matching, transportation modes, speed profile, cells of a cellular network, behaviors of animals, cinemas within 2km distance, and so forth. Symbolic trajectories can be combined with geometric trajectories to obtain annotated trajectories.

Besides the model, the main technical contribution of the article is a language for pattern matching and rewriting of symbolic trajectories. A symbolic trajectory can be represented as a sequence of pairs (called units) consisting of a time interval and a label. A pattern consists of unit patterns (specifications for time interval and/or label) and wildcards, matching units and sequences of units, respectively, and regular expressions over such elements. It may further contain variables that can be used in conditions and in rewriting. Conditions and expressions in rewriting may use arbitrary operations available for querying in the host DBMS environment, which makes the language extensible and quite powerful.
We formally define the data model and syntax and semantics of the pattern language. Query operations are offered to integrate pattern matching, rewriting, and classification of symbolic trajectories into a DBMS querying environment. Implementation of the model using finite state machines is described in detail. An experimental evaluation demonstrates the efficiency of the implementation. In particular, it shows dramatic improvements in storage space and response time in a comparison of symbolic and geometric trajectories for some simple queries that can be executed on both symbolic and raw trajectories.
ECL: an exhaustive search tool for the identification of cross-linked peptides using whole database
Authors: Yu Fengchao , Li Ning , Yu Weichuan 
Published: May 2016

Abstract
Background
Chemical cross-linking combined with mass spectrometry (CX-MS) is a high-throughput approach to studying protein-protein interactions. The number of peptide-peptide combinations grows quadratically with respect to the number of proteins, resulting in a high computational complexity. Widely used methods including xQuest (Rinner et al., Nat Methods 5(4):315–8, 2008; Walzthoeni et al., Nat Methods 9(9):901–3, 2012), pLink (Yang et al., Nat Methods 9(9):904–6, 2012), ProteinProspector (Chu et al., Mol Cell Proteomics 9:25–31, 2010; Trnka et al., 13(2):420–34, 2014) and Kojak (Hoopmann et al., J Proteome Res 14(5):2190–198, 2015) avoid searching all peptide-peptide combinations by pre-selecting peptides with heuristic approaches. However, pre-selection procedures may cause missing findings. The most intuitive approach is searching all possible candidates. A tool that can exhaustively search a whole database without any heuristic pre-selection procedure is therefore desirable.

Results
We have developed a cross-linked peptides identification tool named ECL. It can exhaustively search a whole database in a reasonable period of time without any heuristic pre-selection procedure. Tests showed that searching a database containing 5200 proteins took 7 h.
ECL identified more non-redundant cross-linked peptides than xQuest, pLink, and ProteinProspector. Experiments showed that about 30 % of these additional identified peptides were not pre-selected by Kojak. We used protein crystal structures from the protein data bank to check the intra-protein cross-linked peptides. Most of the distances between cross-linking sites were smaller than 30 Å.

Conclusions
To the best of our knowledge, ECL is the first tool that can exhaustively search all candidates in cross-linked peptides identification. The experiments showed that ECL could identify more peptides than xQuest, pLink, and ProteinProspector. A further analysis indicated that some of the additional identified results were thanks to the exhaustive search.
Geophysical signature of the Victoria property, vectoring toward deep mineralization in the Sudbury Basin
Authors: Spicer Bill 
Published: May 2016

Exploration throughout KGHM International’s Victoria property in Sudbury, Ontario, occurred over an approximate 10-year period and resulted in the discovery of the Victoria Deposit. A variety of geophysical techniques were used with varying results to detect Cu-Ni-PGE-rich ore bodies at depth. Near-surface methods supplemented traditional mapping and geologic interpretation techniques to gain an understanding of property-scale depositional environments. The use of 3C borehole EM surveying facilitated the transition from a broad exploration program, which was based on surface geophysical signatures and geologic principles toward a targeted mineral definition campaign. The presence of off-hole features within several drillholes targeting a lesser massive sulfide lens identified a mass of strong conductors approximately 1 km deep. The drilling of thin-plate forward models derived from the borehole EMs resulted in the intersection of the Victoria Deposit. The tabular deposit has a downdip extent of more than 1500 m and remains open at depth. This significant discovery is an example of the opportunity that remains at depth within the Sudbury Basin, one of the world’s most prolific mining camps.
Origin and distribution of abnormally high pressure in the Mahanadi Basin, east coast of India
Authors: Kumar Ashutosh , Gunasekaran Karthikeyan , Bhardwaj Nitin , Dutta Jayanta , Banerjee Smita 
Published: May 2016

Drilling deep wells in the Mahanadi Basin of the east coast of India is highly challenging because of the variations in pore pressure in the Miocene formations. We have observed that the wells drilled in the northern part of the study area have more drilling hazards due to the presence of high pore pressure (modular dynamic test measurements of up to 18.5 ppg) when compared with wells drilled in the southern part of the basin. In the northern part, pore pressure prediction assuming disequilibrium compaction (DC) underpredicts by approximately 2–3.5 ppg when compared with observed pressures; however, in the southern part, pressure prediction matches the observed pressures in the drilled wells. Analysis of sonic velocity-density crossplots suggests that along with DC, some other secondary mechanism also plays an important role in generating excess overpressure in the northern part of the study area; however, the well data do not indicate the presence of an established secondary mechanism, such as fluid expansion, clay conversion, or cementation. The prime difference between the northern and southern areas is the presence of multiple canyon cuts in the northern part and the observation that very high overpressures occur below these canyon cuts. Hence, an attempt was made to ascertain the relationship between the presence of canyon cuts and the observed high pressure with the help of burial history modeling that incorporates the canyon cut features. Pressure estimation based on this approach closely matches the observed pressures in the drilled wells. This very high overpressure observed in the northern part is most likely generated by the combined effect of porosity rebound (due to overburden removal) along with persistence of overpressures that developed prior to erosion. This burial history modeling approach helps in recognizing and understanding the impact of erosional canyon cut events on generation of excess overpressure in the study area. Furthermore, effective stress methods that take secondary pressure generating mechanisms (unloading) into account are used to quantify the difference in pore pressure.
Melting ice, growing trade?
Authors: Bensassi Sami , Stroeve Julienne C. , Martínez-Zarzoso Inmaculada , Barrett Andrew P. 
Published: May 2016

Abstract
Large reductions in Arctic sea ice, most notably in summer, coupled with growing interest in Arctic shipping and resource exploitation have renewed interest in the economic potential of the Northern Sea Route (NSR). Two key constraints on the future viability of the NSR pertain to bathymetry and the future evolution of the sea ice cover. Climate model projections of future sea ice conditions throughout the rest of the century suggest that even under the most “aggressive” emission scenario, increases in international trade between Europe and Asia will be very low. The large inter-annual variability of weather and sea ice conditions in the route, the Russian toll imposed for transiting the NSR, together with high insurance costs and scarce loading/unloading opportunities, limit the use of the NSR. We show that even if these obstacles are removed, the duration of the opening of the NSR over the course of the century is not long enough to offer a consequent boost to international trade at the macroeconomic level.