bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unique EPIYT motif CagA gene Helicobacter pylori Bali 01 isolate as the cause of hematemesis in a male gastric ulcer patient in Wangaya General Teaching Hospital Denpasar Bali: a case report
Authors: Nirmala Putu Ayu Divya , Bodhinatha Anak Agung Ngurah Paramacarya , Wirajangsa I Gusti Ngurah M. , Wirawan I Made Suma 
Published: September 2024

Background: Helicobacter pylori (H. pylori) infection is related with a number of gastrointestinal disorders, including gastritis, peptic ulcer disease, gastric cancer, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. This case report aims to present an unique EPIYT motif CagA gene H. pylori Bali 01 isolate as the cause of hematemesis in a male gastric ulcer patient
Case Presentation: A 70-year-old male Balinese patient came to the hospital due to hematemesis. Esophagogastroduodenoscopy was performed after stabilizing patient condition with prompt treatment and intravenous proton pump inhibitor. Esophagogastroduodenoscopy revealed a solitary giant ulcer in the gastric antrum. Gastric biopsy was performed and histopathology examination revealed a spherical-like organism, confirmed as H. pylori. Biopsy was sent to the Biomedical Laboratory at West Nusa Tenggara, Mataram, Lombok Island. Culture of biopsy and polymerase chain reaction revealed H. pylori, then named H. pylori Bali 01 isolate. Standard protocol of H. pylori eradication is conducted by administration of triple drug therapy consisting of omeprazole, amoxicillin, and clarithromycin for 14 days. Patient was discharged from hospital in stable condition. Helicobacter pylori was successfully eradicated and revealed completely normal gastric antrum in reperformance of esophagogastroduodenoscopy 3 months later.
Conclusion: The EPIYA-ABD motif on this H. pylori Bali 01 isolate is distinctively unique from the EPIYT motif on the second EPIYA sequence.
Efektifitas N-asetilsistein sebagai terapi tambahan untuk meningkatkan keberhasilan upaya berhenti merokok: tinjauan pustaka
Authors: Wulandari Paradina 
Published: September 2024

Background: Smoking is a major preventable cause of morbidity, disability, and premature death. When you stop smoking, nicotine withdrawal syndrome can occur, making it difficult for smokers to quit. Although smoking cessation rates are low, combining new treatments with counseling may increase success.
Methods: A literature observation study regarding the use of N-acetylcysteine ​​(NAC) for smoking cessation therapy was carried out using data from journals published in WHO, NCBI, PMC, Elsevier, Springer, Researchgate, Wiley online library, and Google Scholar.
Results: N-acetylcysteine ​​(NAC) increases intracellular glutathione levels, a key antioxidant, and modulates immune, oxidative, glutamatergic, and neurotrophic inflammatory pathways. Good as an antioxidant and plays a role in reducing oxidative stress. Administration of NAC is associated with increased glutamate levels and influences the exchange of dopamine release in the central nervous system.
Conclusion: Maintaining levels stimulates the ability of dopamine to reduce withdrawal symptoms and the desire of individuals to quit smoking.

Latar Belakang: Merokok merupakan penyebab utama morbiditas, disabilitas, dan kematian dini yang dapat dicegah. Ketika berhenti merokok, dapat terjadi sindrom putus nikotin, sehingga membuat perokok sulit untuk berhenti. Meskipun tingkat berhenti merokok rendah, menggabungkan pengobatan baru dengan konseling dapat meningkatkan keberhasilan.
Metode: Studi tinjauan pustaka berkaitan dengan penggunaan N-asetilsistein(NAC) untuk terapi upaya berhenti merokok dilakukan dengan menggunakan data dari jurnal yang dipublikasikan di WHO, NCBI, PMC, Elsevier, Springer, Researchgate, Wiley online library, dan Google Scholar.
Hasil: N-asetilsistein (NAC) meningkatkan kadar glutathione intraseluler, antioksidan utama, dan memodulasi jalur inflamasi imun, oksidatif, glutamatergik, dan neurotropik. Baik sebagai antioksidan dan berperan dalam mengurangi stres oksidatif. Pemberian NAC berhubungan dengan peningkatan kadar glutamat dan mempengaruhi pertukaran pelepasan dopamin di sistem saraf pusat.
Simpulan: Mempertahankan tingkat dopamin merangsang kemampuan untuk mengurangi gejala penarikan diri dan keinginan individu yang berkeinginan berhenti merokok.
Tinjauan sistematis faktor risiko kejadian batu ginjal asam urat
Authors: Hananto Geovan , Setiadi Antonius 
Published: September 2024

Background: Uric acid nephrolithiasis is a form of kidney stone disease due to the accumulation of uric acid crystals in the kidneys. High prevalence of uric acid nephrolithiasis might be associated with medical conditions, such as hyperuricemia, diabetes mellitus, hypertension, obesity, and metabolic syndrome. Dietary factors are also often associated with uric acid nephrolithiasis incidence. This systematic review is aimed to determine the risk factors associated with uric acid nephrolithiasis incidence.
Methods: PRISMA guidelines are applied in this systematic review, which began by identifying research articles in ProQuest, PubMed, Science Direct, and BioMed Central during January-June 2024 based on the inclusion and exclusion criteria.
Results: According to the analysis result, it was obtained 15 articles were published in 2014 – 2024 that discussed uric acid nephrolithiasis, gout, diabetes mellitus, hyperuricemia, metabolic syndrome, age, gender, and dietary.
Conclusion: According to the findings, middle-aged or older male (aged ≥ 36) with medical conditions such as metabolic disorder, gout, diabetes, and hyperuricemia are more likely to have a higher risk in uric acid nephrolithiasis incidence, compared to females. Dietary with high sugar (fructose and glucose), salt, and high inflammatory property intakes in both male and female also increases the risk of uric acid nephrolithiasis.

Latar Belakang: Batu ginjal (nefrolitiasis) asam urat merupakan salah satu batu ginjal yang disebabkan akumulasi kristal asam urat di dalam ginjal. Tingginya prevalensi dari batu ginjal asam urat kemungkinan berkaitan dengan kondisi medis seperti hiperurisemia, diabetes mellitus, hipertensi, obesitas, dan sindrom metabolik. Faktor makanan juga sering dikaitkan dengan terjadinya batu ginjal asam urat, namun penyebab yang pasti belum diketahui dengan jelas. Tinjauan sistematis ini bertujuan untuk menentukan faktor risiko yang berkaitan dengan terjadinya batu ginjal asam urat.
Metode: PRISMA digunakan dalam tinjauan sistematis ini, dimulai dengan mengidentifikasi artikel di ProQuest, PubMed, Science Direct, dan BioMed Central selama periode Januari-Juni 2024 berdasarkan kriteria inklusi dan eksklusi.
Hasil: Berdasarkan hasil analisis, didapatkan 15 artikel terbitan tahun 2014 – 2024 yang membahas nefrolitiasis asam urat, gout, diabetes mellitus, hiperurisemia, sindrom metabolik, usia, jenis kelamin, dan diet.
Simpulan: Berdasarkan hasil analisis, pria dengan usia menengah ke atas (≥ 36 tahun) dan memiliki kondisi medis seperti gangguan metabolik, gout, diabetes, dan hiperurisemia memiliki risiko yang lebih tinggi untuk terjadinya nefrolitiasis asam urat, dibandingkan dengan wanita. Diet dengan asupan tinggi gula (fruktosa dan glukosa), garam, dan kejadian inflamasi yang tinggi pada pria dan wanita meningkatkan risiko terjadinya batu ginjal asam urat.
Determining the influence of façade parameters and the width of a fire-proof eaves on preventing the spread of fire through external vertical structures of buildings
Authors: Kagitin Oleksandr , Veselivskyi Roman , Havrys Andrii , Ballo Yaroslav , Yakovchuk Roman , Kovalyshyn Bohdan 
Published: September 2024

The object of this study is the process of fire propagation through the surface of external wall structures with facade thermal insulation. The paper examines the influence of facade parameters and the width of a fire-proof eaves on preventing the spread of fire by external vertical structures using the example of a residential building. With the use of FDS modeling, the relationships between the parameters of external enclosing structures and the fire-proof eaves on the processes of limiting the spread of fire were investigated. The influence of the minimum parameters of the height of the inter-floor windowsill in the absence of a fire-proof eaves on the spread of fire was determined. The dependence of temperature change near the surface of the facade on the width of the fire-proof eaves and the height of the window between floors was established.
Based on a series of simulated experiments, it was established that with a height of 1.0 m between floors and the absence of a fire-proof eaves, the critical temperature value is 250 °C. This value corresponds to the destruction temperature of a standard metal-plastic window structure. For the case when the wall height is 1.0 m, and the width of the fire-proof eaves is 0.75 m, the temperature value is 180 °C. That is, the safety condition of 250 °C is met.
Based on the research, a dependence was found on the criterion of not exceeding the critical temperature of 250 °C at the level of 1.4 m of the facade of the building floor located above the fire floor. The criterion holds when the width of a fire-proof eaves is at least 0.4 m and the height of the window partition is 1.0 m, as well as when the width of the eaves is 0.5 m, and the height of the window partition is 0.6 m.
It was established that the height of a window interfloor partition has a smaller effect than the width of the fire-proof eaves that separates the floors that are located above
Designing a helical knife for a shredding drum using a sweep surface
Authors: Pylypaka Serhii , Hropost Vyacheslav , Nesvidomin Viktor , Volina Tetiana , Kalenyk Mykhailo , Volokha Mykola , Zalevska Olha , Shuliak Ivan , Dieniezhnikov Serhii , Motsak Svetlana 
Published: September 2024

The object of this paper is a helical blade in a shredding drum from a sweep surface. Such drums are used in harvesters for crushing plant mass. If the flat blades are installed on the drum, cutting of the plant mass occurs simultaneously along the entire length of the blade. This could cause a pulsating dynamic load. If a flat knife with a straight blade is installed at an angle to the axis of the drum, then the distances from it to the points of the blade will be different, as well as the cutting conditions along the blade. The elliptical shape enables the same distance from the axis of rotation to the points of the blade, but this does not solve the problem. Many short flat knives with a straight blade can be mounted on the drum, placing them in such a way that the time between the individual knives is minimized. However, all these disadvantages can be eliminated by a helical knife with a blade in the form of a helical line.
The design of a helical knife from an unfolding helicoid has been considered. In differential geometry, the bending of unfolded surfaces of zero thickness is considered. Bending of the workpiece into a finished product occurs with minimal plastic deformations, the magnitude of which depends on the thickness of the workpiece sheet. The methods of differential geometry of unfolding surfaces were applied to the analytical description of the surface of the helical knife.
The parametric equations of the unfolding helicoid were derived according to the given structural parameters of the knife in space and on the plane. That has made it possible to mathematically describe the contour lines that cut the knife from the surface and on its sweep. Formulae for calculating a flat workpiece through the structural parameters of the knife have been derived. Thus, with the specified structural parameters of the knife R=0.25 m, τ=20°, φ=65°, according to the resulting formula, we find the radius of the knife blade on a flat workpiece: R0=4.8 m.
Development of lentil malt production technology using plasma-chemically activated aqueous solutions
Authors: Kovalova Olena , Vasylieva Natalia , Zhulinska Oksana , Balandina Iryna , Zhukova Liubov , Bezpal'ko Valentyna , Horiainova Viktoriia , Trybrat Ruslan , Zazymko Oleksandr , Barkar Yevhen 
Published: September 2024

The result of the implemented research is the development of a technology for sprouted lentil (lentil malt) production using cold plasma-treated aqueous solutions. The object of the study was lentil grain. The main technological task is to obtain high-quality lentil malt suitable for producing gluten-free beer and highly nutritious foods. The rationality of using cold plasma-treated aqueous solutions as an intensifier of lentil grain germination process and high-quality lentil malt disinfectant is experimentally proven. It is confirmed that using cold plasma-treated aqueous solutions can accelerate the process of lentil bean moistening by 2 times. The germination indicators of lentils also experienced positive changes, with germination energy increased by 8–16 %, germination capacity by 3–10 %, and sprout length by 12–29 %. An analysis of the amino acid composition of lentil grain and lentil malt was carried out. Thus, the experimental samples had an increased content of amino acids: non-essential by 2.7 %, essential by 3.6 %. There was also an increase in the content of B vitamins (B1, B2, B5, B9), as well as PP and C, which indicates an increased biological value of lentil malt obtained by the presented technologies. In addition, the work noted the steady antiseptic properties of activated aqueous solutions in relation to lentil malt.
The intensive technology of obtaining lentil malt can be implemented in the industrial production of malt for the brewing industry. In addition, sprouted lentil beans have health-improving properties and can be used in the production of functional products. The presented technology of lentil bean malting will be in demand in the production of highly nutritious and healthy grain products and fermented beverages
Determining the influence of plant-based proteins on the characteristics of dairy ice cream
Authors: Mykhalevych Artur , Polishchuk Galyna , Bandura Uliana , Osmak Tetiana , Bass Oksana 
Published: September 2024

This paper investigates the functional and technological properties of proteins in the composition of dairy ice cream. The object of the research was the technology of ice cream with plant-based proteins. The problem to be solved was the improvement of physical-chemical and rheological characteristics of mixtures and ice cream with a low fat content by using moisture-binding structuring proteins of plant origin.
It was established that pea protein concentrate has the highest foaming properties. Oat protein concentrate shows a moderate ability to form and stabilize foams, while soy protein isolate does not reveal this function at all. The presence of plant-based proteins in all ice cream mixtures increases their nominal viscosity, but the highest thixotropy is observed for the concentrate of pea (56.5–61.0 %) and oat (54.8–57.2 %) proteins. They form food systems with a pronounced coagulation structure, which are capable of self-repair of bonds during the maturation of mixtures for 8 hours. Soy protein isolate reduces the thixotropic ability of ice cream mixtures, which limits the expediency of its use. The defined physical-chemical indicators of ice cream make it possible to justify the rational content of proteins in the composition of ice cream, which is 1–2 % for pea protein concentrate and 1 % for oat protein concentrate.
Data on the rheological behavior of ice cream mixtures do not always coincide with previously established patterns, which is due to the difference in chemical composition between the studied food systems, as well as methods of their preparation and use.
The results of this work could be used in the technology of low-fat ice cream, as well as in compositions for new types of ice cream enriched with protein
Hardware-software implementation of a local Wi-Fi network for the transmission of biomedical signals
Authors: Gerasimova Yuliya , Ivel Victor , Moldakhmetov Sayat , Petrov Pavel 
Published: September 2024

The object of this study is a wireless local Wi-Fi network for broadcasting biomedical signals, its structure, and principles of construction. The task of minimizing the power consumption of a Wi-Fi transmitter has been addressed, which provides the possibility of building a wireless system for long-term monitoring of biomedical signals. As a result, a functional diagram of a wireless Holter monitoring system based on an ESP32 microcontroller was constructed, which includes a subsystem for setting up and diagnosing system units using MATLAB software packages, an ECG signal generator, and a multifunctional PCIe board from National Instruments. Evaluation criteria and methods for minimizing power consumption by an autonomous Wi-Fi transmitter have been proposed. Methods for synchronizing the working cycles of the transmitter and receiver of the Holter monitoring system were determined. A procedure for determining the optimal biosignal measurement frequency is presented, at which the distortion of ECG signals would be minimal, which means that the signal could be transmitted without losses. The concept of constructing an algorithm for implementing a program for a Wi-Fi transmitter has been developed, ensuring parallel execution of ECG signal measurement operations and their transmission over a local network. The data from semi-naturalistic tests with an experimental Holter monitoring system with a pre-setup subsystem and using external measuring devices, a computer, and the MATLAB software environment are presented. A comparative analysis of the experimental data with primary ECG signals and ECG signals at the receiver output showed a fairly stable correspondence between the input and output ECG signals. The proposed algorithms make it possible to reduce the average current consumption of the ESP32 microcontroller to 50.5 mA. The results of the study demonstrate the possibility of constructing an energy-efficient wireless system for long-term monitoring of biomedical signals based on the Wi-Fi interface
Identification of crack width behavior of one-way reinforced concrete slab structure at different steel reinforcement area
Authors: Wisnumurti Wisnumurti , Kridaningrat Bhondana Bayu Brahmana , Soehardjono Agoes , Nuralinah Devi 
Published: September 2024

An evaluation study of crack limit states based on design codes and prior research is presented in this publication. Its main goal is to connect research findings to common design codes. Researchers continue to face a difficult dilemma when it comes to reinforced concrete structure fractures, particularly in one-way slab constructions where there is still significant damage and corrosion in the reinforcement because of cracks. Practitioners will find it easier to construct these structures and solve the slab durability issue if the proper formula is discovered. One can overcome reinforced concrete. A method for estimating the maximum fracture width formula in one-way reinforced concrete slabs with varying steel areas is suggested based on this research. Slabs use a variety of steel areas, including 1000 mm2, 1200 mm2, and 1400 mm2.The test specimens are the same length of 2 meters and have a slab width of 0.6 meters with steel reinforcement. Findings from a literature review of research codes and prediction formulas from earlier studies, namely wmax(prop)=1.5*10-2fsAs-0.4, indicate that the maximum crack width is not significantly influenced by steel area (As). Overall, the findings from the two methods used in this analysis match the suggested formula and the observed experimental testing. This data indicates that the maximum fracture width has been greatly lowered by increasing the steel Area (As) of the reinforced concrete slab, leading to the determination of the experimental formula, As a result, a unique approximation formula has been developed to assess the impact of steel area parameters for pure slabs on the maximum crack width formula for one-way reinforced concrete slabs. This crack width formula is only applicable to one-way slabs in practice.
Developing the composition of fine-grained concrete from the waste of the mining and processing enterprise
Authors: Plugin Andrii , Chaika Vitalii , Musyenko Sergii , Wu Ping , Ye Zhenhua 
Published: September 2024

The object of this study is fine-grained concrete from the waste of mining and processing plants. These wastes are fine-grained dusty sands of polymineral composition. Their use as an aggregate for concrete is restrained by high water consumption, which does not make it possible to obtain sufficient strength for concrete. Therefore, the problem to be solved was the substantiation of the composition of fine-grained concrete from these wastes with mineral and chemical additives, which would ensure obtaining physical-mechanical and hydrophysical properties reasonable for the production of construction articles. The composition of fine-grained concrete from the waste at the Poltava Mining and Processing Plant and slag Portland cement in a ratio of 3:1 and additives of micro silica (15 % of the cement mass) and polycarboxylate superplasticizer (2 % of the cement mass) with W/C=0.5 was obtained. The compressive strength of this concrete reaches 40 MPa, which exceeds the strength of fine-grained concrete of a similar composition on natural fine-grained sand by 3 times. This is due to a greater degree of cement hydration, a greater number of formed hydration products, the presence of silica and quartz particles, a more uniform alternation of gel, silica particles, and crystal hydrates in the structure of cement stone. As a result, the structure contains a larger number of electro heterogeneous contacts between particles and grains that have negative (quartz, calcium hydro silicates) and positive (crystal hydrates of portlandite, hydro aluminates and calcium hydrosulfoaluminate) surface charges. This is what determines the achieved strength and water resistance of fine-grained concrete. The resulting composition of fine-grained concrete is recommended for the production of construction articles.
Synthesis of expert matrices in inductive system-analytical research based on fuzzy logic algorithm
Authors: Osypenko Volodymyr , Korohod Hanna , Zlotenko Borys , Chuprynka Nataliia , Yakhno Volodymyr 
Published: September 2024

The object of research is the process of inductive modeling of complex systems. The studies that were conducted related to the application of algorithms of the fuzzy logic theory were to coordinate the conclusions of top-level experts in system information-analytical research (SIAR) in the tasks of innovative design. The possibilities of constructing elements of expert matrices of results, as well as evaluating the effectiveness of such applications, are defined. Thanks to this, obtaining formal expert evaluations in numerical form became possible. Experimental studies have confirmed that the proposed approach to the application of fuzzy logic algorithms to the construction of matrices of expert evaluations of SIAR results is quite effective and simple to implement. In addition, this approach fits well into the general paradigm of the Group Method of Data Handling (GMDH). In particular, it was established that the possibility of «retraining» such a block without significant efforts of professional experts can have a positive result, as well as have a good effect on the economic and time parameters of the research project. The main calculation formulas for the algorithm for building a fuzzy system using a neural network in a system with two rules are given. The construction of a fuzzy information output system trained on expert evaluations in the Matlab system is shown. As a result, a technologically acceptable standard deviation of 0.28268 mg/l was obtained. It has been established that by accumulating a database (knowledge) and/or using an information monitoring system, it is possible to «additionally train» a fuzzy system periodically or according to the established quality criterion in the program mode, without involving experts in this process. Thus, there are reasons to assert the importance of using a fuzzy system as one of the tools in inductive SIAR procedures