bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complications of chronic hypoparathyroidism according to analysis database Russian Registry
Authors: Kovaleva E. V. , Salimkhanov R. K. , Elfimova A. R. , Eremkina A. K. , Pershina-Miliutina A. P. , Bibik E. E. , Gorbacheva A. M. , Vikulova O. K. , Mokrysheva N. G. 
Published: September 2024

BACKGROUND. Chronic hypoparathyroidism (HypoPT) is a relatively rare endocrine disorder. Adequate control of the disease requires the prescription of lifelong multicomponent therapy. Lack of sustained compensation of HypoPT is associated with the development of both early and delayed complications, including functional and structural renal pathology, cataracts, cerebral calcification, cardiac rhythm and/or conduction disorders, and others.AIM. To study the associations of clinical, laboratory and instrumental parameters, as well as the medical therapy, with long-term complications of chronic HypoPT.MATERIALS AND METHODS. The observational, continuous study was based on the data of the Russian Registry of Patients with Chronic Postoperative and Nonsurgical HypoPT; 1776 patients from 81 regions of the Russian Federation were included in the study.RESULTS. In the study population, 26,3% of patients (n=467) had at least one of the HypoPT complications, among them nephrolithiasis/nephromicrolithiasis was diagnosed in 33,4%. Nephrocalcinosis was observed in 10,7% and was more often bilateral (93,5%). In 17,4% of patients there was a significant decrease in GFR, corresponding to CKD stages 3a-5. Cataract was present in 34,7% of patients with chronic HypoPT. Statistically significant associations were found for disease duration with impaired renal filtration function (p<0,001), nephrocalcinosis/nephrolithiasis (p=0,001) and cataract (p<0,001). Patients with impaired renal function had higher serum ionized calcium level (p=0,0071) and lower phosphorus level (p=0,002). Cataract was predominantly diagnosed in patients of older age group (p<0,001), predominant in the presence of hypocalcemia by ionized calcium level (p=0,001). In patients undergoing brain MSCT for neurological symptoms, basal ganglia calcifications were detected in more than half of the cases (56,2%). Brain calcification was associated with younger patient age (p<0,001), hyperphosphatemia (p<0,001), hypomagnesemia (p=0,010). Statistically significant associations were observed between calcification of brain structures and higher doses of alfacalcidol and calcium carbonate (p=0,007).CONCLUSION. The analysis of the database revealed a number of associations between clinical, laboratory and instrumental parameters and long-term complications of HypoPT. The most significant factors in the development of renal pathology and cataracts are the duration of the disease, as well as off-target indicators of calcium-phosphorus metabolism.
Macrophages modulate skeletal muscle wasting and recovery in acute lung injury in mice
Authors: Krall Jennifer T. W. , Belfield Lanazha , Strysick Claire , Liu Chun , Purcell Lina , Stapleton Renee , Toth Michael , Poynter Matthew , Zhu Xuewei , Gibbs Kevin , Files D. Clark 
Published: September 2024

AbstractSkeletal muscle dysfunction in critical illnesses leaves survivors weak and functionally impaired. Macrophages infiltrate muscles; however, their functional role is unclear. We aim to examine muscle leukocyte composition and the effect of macrophages on muscle mass and function in the murine acute lung injury (ALI)‐associated skeletal muscle wasting model. We performed flow cytometry of hindlimb muscle to identify myeloid cells pre‐injury and time points up to 29 days after intratracheal lipopolysaccharide ALI. We evaluated muscle force and morphometrics after systemic and intramuscular clodronate‐induced macrophage depletions between peak lung injury and recovery (day 5–6) versus vehicle control. Our results show muscle leukocytes changed over ALI course with day 3 neutrophil infiltration (130.5 ± 95.6cells/mg control to 236.3 ± 70.6cells/mg day 3) and increased day 10 monocyte abundance (5.0 ± 3.4%CD45+CD11b+ day 3 to 14.0 ± 2.6%CD45+CD11b+ day 10, p = 0.005). Although macrophage count did not significantly change, pro‐inflammatory (27.0 ± 7.2% day 3 to 7.2 ± 3.8% day 10, p = 0.02) and anti‐inflammatory (30.5 ± 11.1% day 3 to 52.7 ± 9.7% day 10, p = 0.09) surface marker expression changed over the course of ALI. Macrophage depletion following peak lung injury increased muscle mass and force generation. These data suggest muscle macrophages beyond peak lung injury limit or delay muscle recovery. Targeting macrophages could augment muscle recovery following lung injury.
Cigarette smoke exposure impairs early‐stage recovery from lengthening contraction‐induced muscle injury in male mice
Authors: Stevens Nicole E. , Loreti Mafalda , Ramirez‐Sanchez Israel , Dos Reis Felipe C. G. , Sacco Alessandra , Breen Ellen C. , Nogueira Leonardo 
Published: September 2024

AbstractThe use of tobacco cigarettes produces locomotor muscle weakness and fatigue intolerance. Also, smokers and chronic obstructive pulmonary disease patients have a greater incidence of muscle injury and a deficient myogenic response. However, the effects of smoke exposure on the recovery from eccentric exercise‐induced muscle injuries are unknown. Mice were exposed daily to cigarette smoke (CS) or room air (Air) for 4 months; the anterior crural muscles from one limb were injured by a lengthening contractions protocol (LCP) and recovered for 7 days. Lung compliance was greater, and body weights were lower, in CS‐exposed than in the Air group. In LCP‐subjected limbs, CS exposure lowered tibialis anterior myofiber cross‐sectional area, decreased the size of centrally nucleated myofibers, and decreased extensor digitorum longus (EDL) mass, but did not affect EDL force from both limbs. CS exposure upregulated the mRNA levels of several myogenic (Pax7, Myf5, nNOS) genes in the EDL. The combination of CS exposure and LCP decreased Myf5 and nNOS mRNA levels and exacerbated pro‐inflammatory mRNA levels. These data suggest that smoke exposure leads to an excessive pro‐inflammatory response in regenerating muscle that is associated with a lower muscle mass recovery from a type of injury that often occurs during strenuous exercise.
Current developments and advancements of 3-dimensional printing in personalized medication and drug screening
Authors: Tonk Megha , Gupta Vishal , Dhwaj Amar , Sachdeva Monika 
Published: September 2024

Abstract

Introduction
3-Dimensional printing (3DP) is an additive manufacturing (AM) technique that is expanding quickly because of its low cost and excellent efficiency. The 3D printing industry grew by 19.5 % in 2021 in spite of the COVID-19 epidemic, and by 2026, the worldwide market is expected to be valued up to 37.2 billion US dollars.

Content
Science Direct, Scopus, MEDLINE, EMBASE, PubMed, DOAJ, and other academic databases provide evidence of the increased interest in 3DP technology and innovative drug delivery approaches in recent times.

Summary
In this review four main 3DP technologies that are appropriate for pharmaceutical applications: extrusion-based, powder-based, liquid-based, and sheet lamination-based systems are discussed. This study is focused on certain 3DP technologies that may be used to create dosage forms, pharmaceutical goods, and other items with broad regulatory acceptance and technological viability for use in commercial manufacturing. It also discusses pharmaceutical applications of 3DP in drug delivery and drug screening.

Outlook
The pharmaceutical sector has seen the prospect of 3D printing in risk assessment, medical personalisation, and the manufacture of complicated dose formulas at a reasonable cost. AM has great promise to revolutionise the manufacturing and use of medicines, especially in the field of personalized medicine. The need to understand more about the potential applications of 3DP in medical and pharmacological contexts has grown over time.
Green synthesis and effective genistein production by fungal β-glucosidase immobilized on Al2O3 nanocrystals synthesized in Cajanus cajan L. (Millsp.) leaf extracts
Authors: Ali Sikander , Ejaz Afra , Rukhma  , Usman Ahmad M. , Ullah Najeeb , Sarwar Abid , Aziz Tariq , Albekairi Thamer H. , Alshammari Abdulrahman 
Published: September 2024

Abstract
The research deals with the isoflavone genistein production, followed by the β-glucosidase production from Aspergillus oryzae. The Cajanus cajan leaf extract was prepared and the optimized extraction parameters were leaf powder weight (1 g), agitation time (75 min), and temperature (60°C). The optimal conditions for β-glucosidase production by submerged fermentation were 0.4% (w/v) (NH4)2SO4 as nitrogen source, 0.05% (w/v) MgSO4 as magnesium source, 2 ml (v/v) size of inoculum, and 60 min incubation time. The Al2O3 nanocrystals (NCs) were synthesized by optimal volume of leaf extract (25 ml) and procurement period (50 min) along with Al2NO3 and NaOH. The β-glucosidase immobilization on Al2O3 NCs improved the specific activity from 2.38 ± 0.002 to 5.64 ± 0.07 U·mg−1. The maximum genistein production was achieved with the rate of biotransformation (48 h) and enzyme concentration (1% (v/v)) along with the substrate level. In fourier transform infrared spectroscopy analysis, the difference between both β-glucosidases free and Al2O3 immobilized was obtained with peaks at 1,120 and 2,150 cm−1. The X-ray diffraction analysis for the NCs was obtained from 10° to 80° with several intensities. and zeta potential size distribution was recorded at 16.2% of intensity with 206.4 d nm. After immobilization, the stability of the β-glucosidase was increased, thereby increasing its potential in the pharmaceutical, biofuel, food, and beverage industries.
Group boundaries in humor in the online public sphere
Authors: Fiadotava Anastasiya , Chłopicki Władysław 
Published: September 2024

Abstract
One of the fundamental functions of humor is establishing the boundaries between groups. While it is very easy to trace this function in private settings, it often becomes more challenging in the online public sphere, where different groups of humor audiences overlap; there, using audience-restricting references can be counterproductive by establishing boundaries and preventing the efficient spread of jokes. Using the database on humor and conflicts in the public sphere, we look at how humor producers use both in-group specific and widely known humorous references (that we call universal) to create jokes and memes. Based on a corpus of Belarusian and Polish public humor, we outline the most common specific categories of references, analyze how the prevalence of certain categories and types of references depends on the nature of the controversies, and explore the connections between the types of references (verbal or visual) and their nature (in-group and universal).
Migration of two rigid spheres translating within an infinite couple stress fluid under the impact of magnetic field
Authors: El-Sapa Shreen , Alotaibi Munirah Aali 
Published: September 2024

Abstract
In this study, we examine the movement of two hard spheres aligned in a straight line within an incompressible couple stress fluid under the impact of the magnetic field. Both objects have distinct shapes and move along an axis connecting their centers with varying velocities. As a first step, an incompressible analytical analysis is performed on a fluid with couple stress properties around an axially symmetric particle. Using the superposition principle, a general solution is developed for couple stress fluid flows over two moving objects. In order to achieve the boundary conditions, the boundary collocation strategy is applied to the surfaces of the two spheres. A set of tables and graphs illustrates numerical estimates of the dimensionless drag forces acting on two spherical objects. In addition, a drop in Hartmann number or an increase in couple stress viscosity will increase the dimensionless drag force on each spherical particle.
The evolutionary dynamics of grammatical gender in Torricelli languages
Authors: Jódar-Sánchez Jose A. , Allassonnière-Tang Marc 
Published: September 2024

Abstract
Grammatical gender in New Guinea is an often neglected area in typological research, even though it is extremely diverse. For example, in New Guinea, some languages have grammatical gender systems with two sex-based categories, more than four gender-indexing targets, and no gender marking on nouns, while some languages have grammatical gender systems with much more categories, which are only marginally sex-based. This paper infers the processes of development and change of grammatical gender in Torricelli languages from two perspectives. First, it synthesizes the available data in the existing literature and hypothesizes the evolutionary pathway of gender systems in Torricelli languages. Nineteen Torricelli languages are selected as a representative coverage of the 55 Torricelli languages listed in Glottolog within the limits of the available documentation. These languages are then coded based on 6 presence-absence features relating to gender marking on verbs, adjectives, nouns, numerals, pronouns, and demonstratives. Second, it conducts an analysis with phylogenetic comparative methods to provide a quantitative assessment of the evolutionary possibilities for gender systems in Torricelli languages. The preliminary results show that gender is likely marked at the root of Torricelli languages, with pronouns and verbs being at the core of the system. This is in agreement with trends reflecting the evolution of gender systems in languages across the world.
A novel heterozygous likely pathogenic SLC5A2 variant in a diabetic patient with glucosuria and aminoaciduria
Authors: Inthasot Saohoine , Vanderhulst Julien , Janssens Peter , Van Daele Sien , Van Hoof Evelien , Kint Cyrielle , Iconaru Laura , de Filette Jeroen 
Published: September 2024

Summary
Familial renal glucosuria (FRG) is a rare renal tubular disorder characterized by increased urinary glucose excretion despite normoglycemia. It is most commonly caused by pathogenic variants in the solute carrier family V member 2 (SLC5A2) gene. This gene encodes the sodium–glucose cotransporter 2, crucial for glucose reabsorption. We report the case of a 44-year-old male referred to the endocrinology outpatient clinic for unexplained glucosuria despite well-controlled diabetes mellitus with metformin and gliclazide therapy. His main complaints were nocturia and an unintentional 5 kg weight loss in 1 year. A 24-h urinary collection revealed overt glucosuria (23.3 g/1.73 m2/24 h), generalized aminoaciduria, and increased uric acid excretion (fractional excretion: 6.4%). Whole-exome sequencing revealed a novel heterozygous c.469-1G>A likely pathogenic variant in the SLC5A2 gene. Specific analysis of the maturity-onset diabetes of the young type (MODY) gene panel showed no pathogenic variants in the hepatocyte nuclear factor-1A (HNF-1A; MODY3) nor in other MODY-associated genes. We assume that the association of glucosuria, aminoaciduria, and increased uric acid excretion can be explained by the combination of diabetes and the likely pathogenic SLC5A2 variant in this patient. In conclusion, we describe a well-controlled diabetic patient with FRG, associated with a novel heterozygous c.469-1G>A likely pathogenic variant in the SLC5A2 gene.

Learning points

The diagnosis of a renal tubular disorder should be considered in patients with unexplained glucosuria and diabetes mellitus, especially if the latter is well controlled.

FRG usually presents with glucosuria but may be associated with generalized aminoaciduria and hyperuricosuria.

Genetic analysis should be considered in patients with young-onset diabetes and glucosuria, particularly with a positive family history.
CORRUGATED SEMICONDUCTOR NANOMEMBRANES BASED ON STRAINED HETEROSTRUCTURES: FABRICATION AND MAGNETOTRANSPORT
Authors: СЕЛЕЗНЕВ В.А. , ГОЛОД С.В. , ВОРОБЬЁВ А.Б. , КОЗИК Е.В. , ПРИНЦ А.В. , ПРИНЦ В.Я. 
Published: September 2024

Работа посвящена фундаментальным исследованиям в области наномеханики гофрированных полупроводниковых наномембран из напряжённых гетероструктур. Приводятся результаты исследования магнитотранспорта двумерного электронного газа в гофрированной наномембране из гетероплёнки GaAs/InGaAs.
The manuscript considers fundamental research in the field of nanomechanics of corrugated semiconductor nanomembranes composed of strained heterostructures. The results of a study of the magnetotransport of a two-dimensional electron gas in a corrugated nanomembrane made of a GaAs/InGaAs heterofilm are presented.
LOW-TEMPERATURE CONDUCTANCE OF NANOSYSTEMS UNDER CONDITIONS OF WEAK COUPLING WITH A MICROWAVE GENERATOR
Authors: ЯРОШЕВИЧ А.С. , ТКАЧЕНКО В.А. , КВОН З.Д. , КУЗЬМИН Н.С. , ТКАЧЕНКО О.А. , БАКШЕЕВ Д.Г. , МАРЧИШИН И.В. , БАКАРОВ А.К. , РОДЯКИНА Е.Е. , АНТОНОВ В.А. , ПОПОВ В.П. , ЛАТЫШЕВ А.В. 
Published: September 2024

Сильный отклик наносистем на воздействие слабой СВЧ-мощности через зазор между образцом и концом коаксиального кабеля от генератора микроволн обнаружен измерениями при 4,2 К кондактанса короткоканального кремниевого транзистора p -типа, а также образцов с коротким квантовым точечным контактом в двумерном электронном газе гетероструктур GaAs/AlGaAs. Отклик кондактанса был гигантским в туннельном режиме устройств, а вне этого режима знак СВЧ-фотокондактанса зависел от мезоскопического состояния образца и изучаемого интервала по затворному напряжению. Механизм обнаруженных эффектов выяснен моделированием мезоскопического транспорта в рамках одночастичной квантовой механики и формулы Ландауэра, а также анализом принципиальных схем электрического управления полупроводниковым устройством. Найденной основной причиной отклика наносистем на СВЧ-воздействие являются вынужденные синфазные осцилляции заряда в контактах к полупроводнику из-за ёмкостных связей в ближнем металлическом окружении образца.
A strong response of nanosystems to the action of weak microwave power through the gap between the sample and the end of the coaxial cable from the microwave generator is detected by measurements at 4.2 K of the conductance of a short-channel p-type silicon transistor, as well as samples with a short quantum point contact in a two-dimensional electron gas of GaAs/AlGaAs heterostructures. The conductance response is gigantic in the tunnel regime of the devices; outside this regime, the sign of the microwave photoconductance depends on the mesoscopic state of the sample and the gate voltage interval under study. The mechanism of the discovered effects is elucidated by modeling mesoscopic transport within the framework of single-particle quantum mechanics and the Landauer formula, as well as by analyzing the basic circuits of electrical control of the semiconductor device. The main reason for the response of nanosystems to microwave exposure is found to be forced in-phase charge oscillations in contacts to the semiconductor due to capacitive connections in the near metallic environment of the sample.
EFFECT OF HUMIDITY AND ELECTRIC FIELD ON THE PROCESS OF LOCAL ANODIC OXIDATION OF THE SI(111) SURFACE BY AN AFM PROBE
Authors: ЩЕГЛОВ Д.В. , ФЕДИНА Л.И. , ЛАТЫШЕВ А.В. 
Published: September 2024

Исследовано локальное анодное окисление (ЛАО) поверхности Si(111) в контактном режиме работы атомно-силового микроскопа (АСМ) в зависимости от относительной влажности окружающей среды Θ (35-75) % при двух потенциалах U (-8 и -10 В), приложенных к зонду АСМ. Показано, что ЛАО для U = -8 В реализуется при Θ ≥ 40 % в отсутствие роста оксидных линий в ширину, а при U = -10 В их высота и ширина линейно растут во всём интервале значений Θ. Предложена обобщённая модель зависимости процесса ЛАО от U и Θ на основе детального анализа ЛАО и изгиба балки кантилевера при подводе и отводе зонда от поверхности при вариации Θ без напряжения на зонде с учётом данных научной литературы для полуконтактного режима работы АСМ.
Local anodic oxidation (LAO) of the Si(111) surface in the contact mode of an atomic force microscope (AFM) is studied depending on the relative humidity of the ambience - (35-75)% at two potentials U (-8 and -10 V) applied to the AFM probe. It is shown that LAO for U = -8V is realized at Θ ≥ 40% in the absence of growth of oxide lines in width; at U = -10V, their height and width increase linearly over the entire range of Θ values. Based on a detailed analysis of LAO and the deviation of the cantilever during the approach and retraction of the probe from the surface with variation of Θwithout voltage on the probe, taking into account literature data for the semi-contact mode of AFM operation, a generalized model of the dependence of the LAO process on U and Θis proposed.
SURFACE-ENHANCED RAMAN SCATTERING FROM GAP NANOWIRES WITH A GALLIUM DROPLET
Authors: ТАРАНЕНКО А.В. , БАСАЛАЕВА Л.С. , ФЁДОРОВ В.В. , ТУМАШЕВ В.С. , МИЛЁХИН А.Г. 
Published: September 2024

Представлены результаты исследования структурных и оптических свойств массивов и одиночных нанопроволок (НП) GaP ориентации (111) с помощью спектроскопии комбинационного рассеяния света (КРС) и атомно-силовой микроскопии (АСМ). Массивы НП GaP были выращены на подложке Si(111) методом самокаталитического роста по механизму пар - жидкость - кристалл. Одиночные НП GaP были механически перенесены на золотую поверхность. В спектрах КРС НП GaP наблюдались моды поперечных (TO), продольных (LO) и поверхностных (SO) оптических фононов. Обнаружено поверхностно-усиленное КРС фононными модами GaP вблизи галлиевой капли, обусловленное возникающим локализованным поверхностным плазмонным резонансом в капле. Получены карты КРС НП GaP для различной геометрии рассеяния. Коэффициент усиления сигнала КРС для НП GaP диаметром 104 и 60 нм достигает значений ~11 и 6 соответственно.
This paper presents the results of a study of the structural and optical properties of arrays of (111)-oriented GaP nanowires (NWs) and single NWs using Raman spectroscopy and atomic force microscopy (AFM). GaP NW arrays are grown on a (111)-Si substrate by self-catalytic growth via the vapor-liquid-crystal mechanism. Single GaP NWs are mechanically transferred onto a gold surface. Transverse (TO), longitudinal (LO), and surface (SO) optical phonon modes are observed in the Raman spectra of GaP NWs. Surface-enhanced Raman scattering by optical phonon modes in GaP NWs near a gallium droplet is detected, due to the localized surface plasmon resonance in the droplet. Raman maps for GaP NWs recorded on various scattering geometries are obtained. The Raman enhancement factor for GaP NWs with a diameter of 104 and 60 nm reaches values of ~11 and 6, respectively.
IDENTIFICATION OF ACOUSTIC EMISSION SIGNATURES OF THE DIRECT LASER MELTING PROCESS
Authors: СТЕПАНОВА К.А. , КУЗИВАНОВ Д.О. , ФЕДОРОВ А.В. , КИНЖАГУЛОВ И.Ю. 
Published: September 2024

Представлены результаты формирования акустико-эмиссионных образов процессов, происходящих при прямом лазерном выращивании. В рамках экспериментального исследования на различных режимах проведено выращивание образцов из порошкового сплава ЭП 648 с одновременной регистрацией сигналов акустической эмиссии. По результатам анализа параметров зарегистрированных сигналов сформированы их характерные паттерны распределения при лазерном выращивании бездефектных и дефектного образцов.
The paper presents results of identification of acoustic emission signatures of processes occurring during direct laser melting. As part of the experimental study, samples from the powder alloy EP 648 are grown in various modes with simultaneous recording of acoustic emission signals. Based on the results of the analysis of the registered signals parameters, their characteristic distribution patterns are formed during laser melting of defect-free and defective samples.