bluuebunny/crossref_metadata_2025_split huggingface dataset:
New challenges in retinoblastoma treatment
Authors: Desjardins L. , Angi M. , Levy C. , Lumbroso Le Rouic L. , Aerts I. , Freneaux P. , Brisse H. , Cassoux N. 
Published: September 2016

PurposeRetinoblastoma treatment has changed during the past ten years with the introduction of intraarterial and intravitreal chemotherapy. There is a trend to more conservative management and the challenge is to decide when to enucleate.MethodsWe have made a retrospective study of patients treated in 2013 and 2014.Unilateral retinoblastoma were treated by intraarterial melphalan and local treatments in selected cases and enucleation for advanced group D and for all group E eyes For bilateral retinoblastoma, conservative management was proposed with intravenous chemotherapy and local treatments Follow up every month under general anesthesia during the first year with treatment of small recurrences by laser or cryotherapy was performedResultsThere were 40 bilateral retinoblastoma and 4 of them were metachronous.19 patients received 6 courses of 3 drugs and 21 received two courses of VP16 and carboplatin followed by carboplatin. All the children had local ophthalmological treatments started at the third cycle. 21 children kept both eyes and 19 kept one eye. There were 72 unilateral retinoblastoma .43 (60%) were treated with primary enucleation and 29 (40%) were treated by conservative management. 21 of these eyes were saved and 8 were secondary enucleated. No patient developed orbital recurrence, optic nerve involvement or metastasis.ConclusionsThe increase of conservative management in retinoblastoma is safe with proper selection of eyes and close follows up.
RESVEGA in exudative age‐related macular degeneration
Authors: Kubicz A. 
Published: September 2016

PurposeThe aim of this clinical case is to present the improvement of retinal structure and stabilisation of visual acuity using RESVEGA (trans‐resveratrol and omega‐3 fatty acids i.a.) in a patient with exudative AMD.MethodsA 84‐year‐old female patient with pseudophakia and history of dry AMD in both eyes and atrophic changes in the left eye presented in mid‐January 2015 with deterioration of vision in the right eye. VOD: 0.1, no improvement with correction; VOS: counts fingers from 1.5 m. In the OCT: subretinal fluid, suspected CNV in the right eye, atrophic changes in the left eye. Recommended: fluorescein angiography, qualification for intravitreal anti‐VEGF injection into RE and supplementation with RESVEGA (2 tablets daily at once). FFA – increasing hyperfluorescence in the RE macula, leakage from CNV and changes of atrophic character in the course of AMD. February 2015 (qualification for intravitreal anti‐VEGF injection): RE: significant improvement in OCT, decreased fluid space under the sensory retina. VOD, VOS as previously. Injections were abandoned; recommended: continued supplementation with RESVEGA, frequent ophthalmic examinations. Mid‐March 2015: in the OCT no fluid spaces. VOD, VOS as previously. Recommended: observation and continued supplementation as so far. September 2015: in the OCT – no fluid spaces. VOD, VOS as previously.ResultsOwing to the use of RESVEGA, regression of the subretinal fluid was obtained. It was possible not to introduce the intravitreal anti‐VEGF injection. The oral therapy ensured maintaining stable ophthalmological status and visual acuity on the same level within 9 months of observation.ConclusionsRESVEGA supplementation allowed to maintain stable condition of patient's eyes, without anti‐VEGF injection.
Cacicol® – neurotrophic keratopathy in systematic review
Authors: Mrukwa Kominek E. , Rokicki D. 
Published: September 2016

PurposeThe objective of this study was to review the cases of neurotrophic keratopathy with use of the new regenerating agent (RGTA) therapy Cacicol®.MethodsAn analysis was based on documents retrieved from the systematic research on published materials. Bibliometric analysis were performed using own design database. Research has been concentrated on publications, conference abstracts and posters presenting case reports with detailed medical history. Neurotrophic keratopathy patients have been grouped according to diagnosis based on the best assessment of the data presented in the collected materials. In all groups posology, duration of treatment, healing level and tolerance have been assessed by descriptive methods.Results58 publications have been consecutively retrieved and reviewed from which 37 have been qualified for further review. In this materials 102 patients with 105 eyes have been selected as detailed data of Cacicol® use, performance and tolerance could be identified. The total number of eyes have been divided into 4 groups: postinfectious (n = 33), postoperative (n = 25), neurological (n = 36), chemical burns (n = 11). Analysis revealed that in all groups more than 72% of patients achieved corneal healing/partial healing after average treatment of 4 weeks (from 4 days to 22 weeks). Only 6% of cases did not heal and <2% presented unexpected effect. In the most cases posology covered 1 drop every 2 or 3 days. The recurrence rate of the neurotrophic ulcers after the complete healing was reported up to 20% within 6 months.ConclusionsCacicol® might be considered as an alternative approach in the neurotrophic keratopathy management. However randomised clinical trial in patients in this indication is necessary to confirm the promising effect of Cacicol® in the neurotrophic keratopathy management.
Ambient exposure of the ocular tissues to optical radiation
Authors: Soderberg P. , Yu Z. , Talebizadeh N. , Malmqist L. , Sandberg Melin C. , Galichanin K. 
Published: September 2016

SummaryOptical radiation is usually considered as radiation between 1 nm and 1 mm. The visible part of optical radiation typically extends from 400 and 760 nm. Optical radiation with wavelengths shorter than visible is referred to as ultraviolet radiation (UVR) and optical radiation with wavelengths longer than visible as infrared radiation (IRR). The most abundant source of optical radiation on the earth is daylight sun. The spectral emission of the sun is determined by the sun temperature, 5,778 K and the atmospheric attenuation. In environments with high backhground reflection of UVR the UVR from the sun at the surface of the earth may cause photochemical damage to the human eye. Humans have continuously increased the light load on the visual system by inventions like the fire, the incandescent‐ and the halogen‐ lamp, fluorescent tubes and recently the LED lamp. The primary emission from halogen lamps and fluorescent tubes contains enough UVR to cause photochemical damage to the eye if not fitted with suitable filters. Even when fitted with UVR blocking filters these sources increase the load of blue light on the retina that potentially causes photochemical damage. LED lamps used for illumination typically are blue emitting diodes with fluorescent coating that provides a white light sensation to the visual system. The spectral output typically has a strong peak in the blue balanced by a broad peak in red. The blue light potentially causes photochemical damage in the retina. The deviation of the spectral distribution of the LED lamp from that of the sun challenges the color perception of the visual system in the aging eye and after cataract surgery with blue blocking IOLs due to increased selective blue light absorption. Increasing use of IRR LEDs for remote sensing and control is a potential hazard to the anterior segment of the eye.
Estimation of genetic (co)variances of Gompertz growth function parameters in pigs
Authors: Coyne J.M. , Matilainen K. , Berry D.P. , Sevon‐Aimonen M.– L. , Mäntysaari E.A. , Juga J. , Serenius T. , McHugh N. 
Published: September 2016

SummaryThe objective of this study was to estimate genetic (co)variances for the Gompertz growth function parameters, asymptotic mature weight (A), the ratio of mature weight to birthweight (B) and rate of maturation (k), using alternative modelling approaches. The data set consisted of 51 893 live weight records from 10 201 growing pigs. The growth of each pig was modelled using the Gompertz model employing either a two‐step fixed effect or mixed model approach or a one‐step mixed model approach using restricted maximum likelihood for the estimation of genetic (co)variance. Heritability estimates for the Gompertz growth function parameters, A (0.40), B (0.69) and k (0.45), were greatest for the one‐step approach, compared with the two‐step fixed effects approach, A (0.10), B (0.33) and k (0.13), and the two‐step mixed model approach, A (0.17), B (0.32) and k (0.18). Inferred genetic correlations (i.e. correlations of estimated breeding values) between growth function parameters within models ranged from −0.78 to 0.76, and across models ranged from 0.28 to 0.73 for parameter A, 0.75 to 0.88 for parameter B and 0.09 to 0.37 for parameter k. Correlations between predicted daily sire live weights based on the Gompertz growth curve parameters’ estimated breeding values from 60 to 200 days of age between all three modelled approaches were moderately to strongly correlated (0.75 to 0.95). Results from this study provide heritability estimates for biologically interpretable parameters of pig growth through the quantification of genetic (co)variances, thereby facilitating the estimation of breeding values for inclusion in breeding objectives to aid in breeding and selection decisions.
A Popular myth – low‐histamine diet improves chronic spontaneous urticaria – fact or fiction?
Authors: Wagner N. , Dirk D. , Peveling‐Oberhag A. , Reese I. , Rady‐Pizarro U. , Mitzel H. , Staubach P. 
Published: September 2016

AbstractBackgroundChronic spontaneous urticaria (CsU) is a frequent dermatological disease that might last for months or years with high impact on quality of life. Known causes are autoreactive phenomena, infections or intolerances, rarely IgE‐mediated allergies. One‐third of CsU patients benefit from a low‐pseudoallergen diet. Additionally, it is often discussed, that reducing histamine ingestion alone might improve clinical symptoms and quality of life in CsU patients despite the uncertain role of the histamine‐degrading enzyme diamine oxidase (DAO).ObjectiveAim of this study was to investigate the impact of low‐histamine diet on symptoms and quality of life in patients with CsU.MethodsPatients suffering from CsU accompanied by gastrointestinal symptoms were included in the study. They underwent low‐histamine diet for at least 3 weeks. During the whole study, urticaria activity score (UAS) was recorded daily in a patient′s diary. Quality of life was assessed during screening, baseline and post diet visits by completing questionnaires (DLQI and Cu‐Q(2)oL). DAO activity was measured before and after elimination diet.ResultsA total of 75% of the patients had a benefit from the low‐histamine diet. Thirty‐four of 56 patients (61%) reached the primary endpoint of the study, an improvement of UAS 4 of ≥3. Overall, a significant reduction from 9.05 to 4.23 points (P = 0.004) was achieved; the average reduction in a strongly affected subgroup was 8.59 points (P < 0.001). DAO activity remained stable.ConclusionLow‐histamine diet is a therapeutically useful, simple and cost‐free tool to decrease symptoms and increase quality of life in CsU patients with gastrointestinal involvement. Further research is needed to understand the role of diamine oxidase.
Ecological Traits of the Algae‐BearingTetrahymena utriculariae(Ciliophora) from Traps of the Aquatic Carnivorous PlantUtricularia reflexa
Authors: Šimek Karel , Pitsch Gianna , Salcher Michaela M. , Sirová Dagmara , Shabarova Tanja , Adamec Lubomír , Posch Thomas 
Published: September 2016

AbstractTrap fluid of aquatic carnivorous plants of the genusUtriculariahosts specific microbiomes consisting of commensal pro‐ and eukaryotes of largely unknown ecology. We examined the characteristics and dynamics of bacteria and the three dominant eukaryotes, i.e. the algae‐bearing ciliateTetrahymena utriculariae(Ciliophora), a green flagellateEuglena agilis(Euglenophyta), and the algaScenedesmus alternans(Chlorophyta), associated with the traps ofUtricularia reflexa. Our study focused on ecological traits and life strategies of the highly abundant ciliate whose biomass by far exceeds that of other eukaryotes and bacteria independent of the trap age. The ciliate was the only bacterivore in the traps, driving rapid turnover of bacterial standing stock. However, given the large size of the ciliate and the cell‐specific uptake rates of bacteria we estimated that bacterivory alone would likely be insufficient to support its apparent rapid growth in traps. We suggest that mixotrophy based on algal symbionts contributes significantly to the diet and survival strategy of the ciliate in the extreme (anaerobic, lowpH) trap‐fluid environment. We propose a revised concept of major microbial interactions in the trap fluid where ciliate bacterivory plays a central role in regeneration of nutrients bound in rapidly growing bacterial biomass.
Using mixed‐methods research to study the quality of life of coeliac women
Authors: Rodríguez Almagro Julián , Hernández Martínez Antonio , Solano Ruiz María Carmen , Siles González José 
Published: September 2016

Aims and objectivesTo research the quality of life of Spanish women with coeliac disease.BackgroundWomen with coeliac disease express lower quality of life than men with coeliac disease.DesignExplanatory sequential approach using mixed methods and with a gender perspective.MethodsThe research was carried out between May and July 2015. In its quantitative stage, it aimed to determine the health‐related quality of life in a representative sample (n = 1097) of Spanish adult women with coeliac disease using a specific questionnaire named Coeliac Disease‐Quality of Life. In its qualitative phase, it aimed to describe the life experiences of a woman with coeliac disease in a qualitative manner by means of interviews (n = 19) with a semistructured script. Quantitative data were analysed using spss version 20 and presented in descriptive statistics. Qualitative data were analysed using the directed content analysis.ResultsThe quantitative process gave us the values on the four aspects studied: dysphoria, disease limitations, health problems and inadequate treatment. These aspects allowed us to create a qualitative process, based on which we generated an interview, from which four larger categories emerged. These categories were feelings at diagnosis, limitations in day‐to‐day life, social perceptions of the disease and personal meanings of coeliac disease. Thus, both phases of our project are totally connected. There was a high level of congruence between quantitative scores and narratives.ConclusionThis study shows us the strong points of mixed‐methods strategy in health sciences. The mixed‐methods strategy gave us a wider view of the experience of women living with coeliac disease. In our case, a strength and not a limitation is having performed the quality of life study in women with coeliac disease using a mixed methodology, approaching the experience of being a woman with coeliac disease in Spain in two different but complementary ways. The quantitative and qualitative data allowed us to interpret the experiences of our participants.
Interventional Closure of Secundum Type Atrial Septal Defects in Infants Less Than 10 Kilograms: Indications and Procedural Outcome
Authors: Wyss Yves , Quandt Daniel , Weber Roland , Stiasny Brian , Weber Benedikt , Knirsch Walter , Kretschmar Oliver 
Published: September 2016

AimsThis study set out to assess indications, feasibility, complications, and clinical outcome of percutaneous transcatheter device closure of atrial septal defects (ASDs) in infants with a bodyweight below 10 kg.Methods and ResultsRetrospective single center chart and echocardiography review study from 8/2005–12/2013. Twenty‐eight children with ASD (13 female) with a median age of 1.15 years (0.2–2.8) and a median weight of 7.2 kg (4.5–9.9) were analyzed. Indications for early ASD closure were failure to thrive (n = 15, 54%), bronchopulmonary dysplasia (BPD) with supplemental oxygen dependency (n = 7, 25%), and genetic syndromes with suspected pulmonary hypertension (n = 12, 43%). Device implantation was successful in all patients without any periprocedural mortality or major complication. Clinical outcome after a median follow‐up period of 2.1 years (0.25–7.3) revealed no residual shunt and a significant decrease of right ventricular volume load. Patients with pulmonary hypertension experienced a significant reduction of pulmonary artery/RV pressure. Patients also showed decreased supplemental oxygen dependency and less cardiac medications, but no significant “catch‐up growth” in those with failure to thrive.ConclusionInterventional ASD closure in children weighing less than 10 kg can be performed without any additional major risks and shows a favorable outcome, especially in selected patients with significant non cardiac co‐morbidities.
Performance of the XLIMUS Sirolimus‐Eluting Coronary Stent in Very Complex Lesions
Authors: Briguori Carlo , Visconti Gabriella , Donahue Michael , Di Palma Vito , De Micco Francesca , Signoriello Giuseppe , Focaccio Amelia 
Published: September 2016

IntroductionStent delivery failure may occur especially when treating complex coronary artery stenosis. XLIMUS (CARDIONOVUM GmbH, Bonn, Germany) is a new sirolimus‐eluting stent (SES) with the following features: 1) cobalt chromium stent platform, with low (73 μm) strut thickness, (2) biodegradable polymer, and 3) potent antiproliferative drug (Sirolimus). Preliminary data suggest that XLIMUS SES may be ideal for the treatment of complex lesions.MethodsIn this registry, we assessed the deliverability, safety, and efficacy of percutaneous coronary interventions (PCI) using the XLIMUS SES in patients undergoing elective PCI in native coronary vessels for complex de novo lesions, including severe calcification, severe tortuosity, and chronic total occlusion. The primary objective of the study is the delivery success of the XLIMUS SES. The secondary objective is the 1‐year rate of major adverse cardiac events (MACE; including all‐cause death, nonfatal myocardial infarction, and repeat revascularization).ResultsA total of 200 consecutive patients with 255 lesions were included. Delivery success was obtained in 196 (98%) patients and in 251 (98.4%) lesions. The XLIMUS SES was successfully implanted on the first attempt with a single guidewire in 176 (88%) patients and in 208 (81.6%) lesions. Additional techniques to facilitate stent delivery (i.e., buddy wire, anchoring‐balloon, or GuideLiner catheter) were necessary in 47 (18.4%) lesions. Failure in XLIMUS SES implantation occurred in 4 (1.6%) lesions. MACE rate at 1 year was 9%.ConclusionsThis registry supports the positive performance of the XLIMUS SES in the treatment of complex coronary artery lesions.
The effect of health and dental insurance on US children's dental care utilization for urgent and non‐urgent dental problems ‐ 2008
Authors: Naavaal Shillpa , Barker Laurie K. , Griffin Susan O. 
Published: September 2016

AbstractObjectiveWe examined the association between utilization of care for a dental problem (utilization‐DP) and parent‐reported dental problem (DP) urgency among children with DP by type of health care insurance coverage.MethodsWe used weighted 2008 National Health Interview Survey data from 2,834 children, aged 2–17 years with at least one DP within the 6 months preceding survey. Explanatory variables were selected based on Andersen's model of healthcare utilization. Need was considered urgent if DP included toothache, bleeding gums, broken or missing teeth, broken or missing filling, or decayed teeth and otherwise as non‐urgent. The primary enabling variable, insurance, had four categories: none, private health no dental coverage (PHND), private health and dental (PHD), or Medicaid/State Children's Health Insurance Program (SCHIP). Predisposing variables included sociodemographic characteristics. We used bivariate and multivariate analyses to identify explanatory variables’ association with utilization‐DP. Using logistic regression, we obtained adjusted estimates of utilization‐DP by urgency for each insurance category.ResultsIn bivariate analyses, utilization‐DP was associated with both insurance and urgency. In multivariate analyses, the difference in percent utilizing care for an urgent versus non‐urgent DP among children covered by Medicaid/SCHIP was 32 percentage points; PHD, 25 percentage points; PHND, 12 percentage points; and no insurance, 14 percentage points. The difference in utilization by DP urgency was higher for children with Medicaid/SCHIP compared with either PHND or uninsured children.ConclusionExpansion of Medicaid/SCHIP may permit children to receive care for urgent DPs who otherwise may not, due to lack of dental insurance.
Identification, transcriptional and functional analysis of heat‐shock protein 90s in banana (Musa acuminata L.) highlight their novel role in melatonin‐mediated plant response to Fusarium wilt
Authors: Wei Yunxie , Hu Wei , Wang Qiannan , Zeng Hongqiu , Li Xiaolin , Yan Yu , Reiter Russel J. , He Chaozu , Shi Haitao 
Published: September 2016

AbstractAs one popular fresh fruit, banana (Musa acuminata) is cultivated in the world's subtropical and tropical areas. In recent years, pathogen Fusarium oxysporum f. sp. cubense (Foc) has been widely and rapidly spread to banana cultivated areas, causing substantial yield loss. However, the molecular mechanism of banana response to Foc remains unclear, and functional identification of disease‐related genes is also very limited. In this study, nine 90 kDa heat‐shock proteins (HSP90s) were genomewide identified. Moreover, the expression profile of them in different organs, developmental stages, and in response to abiotic and fungal pathogen Foc were systematically analyzed. Notably, we found that the transcripts of 9 MaHSP90s were commonly regulated by melatonin (N‐acetyl‐5‐methoxytryptamine) and Foc infection. Further studies showed that exogenous application of melatonin improved banana resistance to Fusarium wilt, but the effect was lost when cotreated with HSP90 inhibitor (geldanamycin, GDA). Moreover, melatonin and GDA had opposite effect on auxin level in response to Foc4, while melatonin and GDA cotreated plants had no significant effect, suggesting the involvement of MaHSP90s in the cross talk of melatonin and auxin in response to fungal infection. Taken together, this study demonstrated that MaHSP90s are essential for melatonin‐mediated plant response to Fusarium wilt, which extends our understanding the putative roles of MaHSP90s as well as melatonin in the biological control of banana Fusarium wilt.