bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rendimiento, estabilidad fenotípica y contenido de micronutrientes de fríjol biofortificado en el Caribe seco colombiano
Authors: Tofiño-Rivera Adriana Patricia , Pastrana-Vargas Iván Javier , Melo-Ríos Aslenis Emidia , Beebe Stephen , Tofiño-Rivera Rodrigo 
Published: August 2016

La ingesta de proteína y micronutrientes en el Caribe seco colombiano en los últimos años ha sido motivo de preocupación pues cerca del 57 % de sus habitantes tiene déficit de aminoácidos, hierro (Fe) y zinc (Zn) en su dieta. Este artículo muestra los resultados de la evaluación multilocal agronómica de rendimiento y calidad de la semilla de nueve genotipos de fríjol biofortificado y un testigo local en el Cesar. La metodología incluyó la caracterización química y microbiológica del suelo, la evaluación de reacción a plagas y enfermedades, la valoración multilocal por AMMI y la selección de dos genotipos con el mejor comportamiento y contenido nutricional por ACP. Adicionalmente, para los genotipos priorizados, se determinó el coeficiente de correlación de Pearson en el contenido de micronutrientes de semilla por localidades y años. Los genotipos biofortificados superaron significativamente en rendimiento y precocidad al testigo. Según el ACP, el grupo de biofortificados se diferenció del testigo en contenido de hierro y zinc en la semilla, lo cual confirmó su superioridad en calidad nutricional, y una mayor resistencia a plagas y enfermedades. El AMMI arrojó que el genotipo SMR43 evidenció estabilidad y predictibilidad entre ambientes y el SMR39 tuvo adaptación específica en la mejor localidad para producción de grano. Ambos genotipos conservaron niveles elevados de micronutrientes entre localidades y a lo largo del tiempo según correlación de Pearson.
A NuSTAR OBSERVATION OF THE REFLECTION SPECTRUM OF THE LOW-MASS X-RAY BINARY 4U 1728-34
Authors: Sleator Clio C. , Tomsick John A. , King Ashley L. , Miller Jon M. , Boggs Steven E. , Bachetti Matteo , Barret Didier , Chenevez Jérôme , Christensen Finn E. , Craig William W. , Hailey Charles J. , Harrison Fiona A. , Rahoui Farid , Stern Daniel K. , Walton Dominic J. , Zhang William W. 
Published: August 2016

ABSTRACT
We report on a simultaneous NuSTAR and Swift observation of the neutron star low-mass X-ray binary 4U 1728-34. We identified and removed four Type I X-ray bursts during the observation in order to study the persistent emission. The continuum spectrum is hard and described well by a blackbody with kT = 1.5 keV and a cutoff power law with Γ = 1.5, and a cutoff temperature of 25 keV. Residuals between 6 and 8 keV provide strong evidence of a broad Fe Kα line. By modeling the spectrum with a relativistically blurred reflection model, we find an upper limit for the inner disk radius of

. Consequently, we find that R
NS ≤ 23 km, assuming M = 1.4 M
⊙ and a = 0.15. We also find an upper limit on the magnetic field of B ≤ 2 × 108 G.
INFRARED OBSERVATIONS OF THE QUINTUPLET PROPER MEMBERS USING SOFIA/FORCAST AND GEMINI/TReCS
Authors: Hankins M. J. , Lau R. M. , Morris M. R. , Sanchez-Bermudez J. , Pott J. U. , Adams J. D. , Herter T. L. 
Published: August 2016

ABSTRACT
Since their discovery, the Quintuplet proper members (QPMs) have been somewhat mysterious in nature. Originally dubbed the “cocoon stars” due to their cool featureless spectra, high-resolution near-infrared imaging observations have shown that at least two of the objects exhibit “pinwheel” nebulae consistent with binary systems with a carbon-rich Wolf–Rayet star and O/B companion. In this paper, we present 19.7, 25.2, 31.5, and 37.1 μm observations of the QPMs (with an angular resolution of 3.2″–3.8″) taken with the Faint Object Infrared Camera for the SOFIA Telescope (FORCAST) in conjunction with high-resolution (∼0.1″–0.2″) images at 8.8 and 11.7 μm from the Thermal-Region Camera Spectrograph (TReCS). DUSTY models of the thermal dust emission of two of the four detected QPMs, Q2 and Q3, are fitted by radial density profiles that are consistent with constant mass-loss rates (

). For the two remaining sources, Q1 and Q9, extended structures (∼1″) are detected around these objects in high-resolution imaging data. Based on the fitted dust masses, Q9 has an unusually large dust reservoir (

) compared to typical dusty Wolf–Rayet stars, which suggests that it may have recently undergone an episode of enhanced mass loss.
Le « tripartisme de légitimation politique » ou la face (post-) démocratique des « capitalismes dépendants » : les cas de la Bulgarie et de la Roumanie
Authors: Delteil Violaine 
Published: August 2016

Le tripartisme a fait l’objet d’un engouement de la première heure dans les pays d’Europe centrale et orientale. Si en Europe centrale cette institutionnalisation est restée souvent formelle, dans les Balkans, orientaux comme occidentaux, le dialogue social au sommet a fait l’objet d’une mobilisation et d’une instrumentalisation marquée et continue de la part des gouvernements. Prenant appui sur une comparaison entre la Bulgarie et la Roumanie, le présent article propose d’expliciter les traits inhérents aux deux expériences de tripartisme, depuis le début de la transition jusqu’à la dernière crise. L’identification d’un « tripartisme de légitimation politique », qui rejoint et complète la thèse du « corporatisme illusoire » de David Ost (2000), est reliée à deux questionnements qui traversent aujourd’hui la recherche : le premier renvoie au rôle décisif joué par les facteurs externes sur le jeu sociopolitique domestique, pour ces deux pays qui exemplifient le modèle de « capitalisme dépendant » ; le second renvoie aux modalités et aux canaux de l’européanisation sociale dans l’Union européenne élargie, ici appliquée au dialogue social.
Effects of factor XIII deficiency on thromboelastography. Thrombelastography with calcium and lysis by addition of streptokinase is more sensitive than solubility tests
Authors: Martinuzzo Marta E 
Published: August 2016

Background:Homozygous or double heterozygous factor XIII (FXIII) deficiency is characterized by soft tissue hematomas, intracranial and delated spontaneous bleeding. Alterations of thromboelastographic (TEG) parameters in these patients have been reported. The aim of the study was to show results of TEG, TEG Lysis (Lys 60) induced by subthreshold concentrations of streptokinase (SK), and to compare them to the clot solubility studies results in samples of a1 year old girl with homozygous or double heterozygous FXIII deficiency.Materials and Methods:Case: A one year girl with history of bleeding from umbilical cord. During her first year of live several hematomas in soft upper limb tissue after punctures for vaccination and a gluteal hematoma appeared. One additional sample of a heterozygous and three of acquired FXIII deficiency were also evaluated.Materials and Methods: clotting tests, von Willebrand factor (vWF) antigen and activity, plasma FXIII-A (pFXIII-A) subunit were measured by an immunoturbidimetric assays in a foto-optical coagulometer. Solubility tests were performed with Ca2+-5 M urea and thrombin-2% acetic acid. Basal and post FXIII concentrate infusion samples were studied. TEG was performed with CaCl2 or CaCl2 + SK (3.2 U/mL) in a Thromboelastograph. Results: Prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time, fibrinogen, factor VIIIc, vWF and platelet aggregation were normal. Antigenic pFXIII-A subunit was < 2%. TEG presented a normal reaction time (R), 8 min, prolonged k (14 and11min), low Maximum amplitude (MA), 39 and 52 mm, and Clot Lysis (Lys60) slightly increased (23 and 30%) at diagnosis and post FXIII concentrate infusion (pFXIII-A= 37%), respectively. In Sample at diagnosis clot solubility was abnormal, 50 and 45 min with Ca-Urea and thrombin-acetic acid, respectively, but normal (>16 hours) 1 day post FXIII infusion. Analysis of FXIII deficient and normal plasma mixtures (< 2 -102% of pFXIII-A), showed that Ca-urea solubility was abnormal at pFXIII-A < 9%, thrombin-acetic acid at pFXIII-A<18%, but TEG MA and elasticity at 23% and Lys60 with SK at pFXIII-A< 40%.Conclusions: TEG parameters MA and elasticity, and Lys 60 in TEG with Ca2+ and in TEG Ca2+ and SK are more sensitive to low levels of pFXIII than solubility tests. The increased Lys60 induced by subthreshold concentration of SK could probably reflect the clot characteristics “in vivo” in many patients with pFXIII levels between 5-40% and could be potentially considered as screening test.
Study of interleukin-6 and interleukin-8 levels in patients with neurological manifestations of dengue
Authors: Mehta VK , Verma R , Garg RK , Malhotra HS , Sharma PK , Jain A 
Published: August 2016

Context:
Pro-inflammatory markers play a key role in the pathogenesis of various Flavivirus infection.

Aim:
In this study, we evaluated the role of these markers in neurological manifestations of dengue.

Settings and Designs:
Consecutive dengue cases with different neurological manifestations who presented between August 2012 and July 2014 were studied in hospital-based case–control study.

Materials and Methods:
Interleukin (IL-6) and IL-8 level were measured in serum and cerebrospinal fluid (CSF) of dengue cases with different neurological manifestations and also in age- and sex-matched controls. Level was analyzed with various parameters and outcomes.

Statistical Analysis:
Statistical analysis was done using SPSS version 16.0 by applying appropriate statistical methods. P < 0.05 considered statistically significant.

Results:
Out of the 40 enrolled cases of dengue with neurological manifestations, 29 had central nervous system and 11 had peripheral nervous system (CNS/PNS) manifestations. In CNS group, both IL-6 and IL-8 (CSF and serum) were significantly elevated (P < 0.001), whereas CSF IL-6 (P = 0.008), serum IL-6 (P = 0.001), and serum IL-8 (P = 0.005) were significantly elevated in PNS group. CSF IL-6, serum IL-6, and IL-8 were significantly elevated in poor outcome patients in CNS group (P < 0.05). CSF IL-6 and IL-8 were significantly elevated in CSF dengue positive cases as compared to CSF negative patients (P < 0.05). Cytokine level was not significantly correlated with neuroimaging abnormality in CNS group. Nine patients died and the remainder recovered.

Conclusion:
Elevated level of IL-6 and IL-8 is associated with different neurological manifestations and poor outcome, but whether they are contributing to neuropathogenesis or simply a correlate of severe disease remains to be determined.
Age, Neurological Status MRC Scale, and Postoperative Morbidity are Prognostic Factors in Patients with Glioblastoma Treated by Chemoradiotherapy
Authors: Verlut Clotilde , Mouillet Guillaume , Magnin Eloi , Buffet-Miny Joëlle , Viennet Gabriel , Cattin Françoise , Billon-Grand Nora Clelia , Bonnet Emilie , Servagi-Vernat Stéphanie , Godard Joël , Billon-Grand Romain , Petit Antoine , Moulin Thierry , Cals Laurent , Pivot Xavier , Curtit Elsa 
Published: August 2016

Introduction Temozolomide and concomitant radiotherapy followed by temozolomide has been used as a standard therapy for the treatment of newly diagnosed glioblastoma multiform since 2005. A search for prognostic factors was conducted in patients with glioblastoma routinely treated by this strategy in our institution. Methods This retrospective study included all patients with histologically proven glioblastoma diagnosed between June 1, 2005, and January 1, 2012, in the Franche-Comté region and treated by radiotherapy (daily fractions of 2 Gy for a total of 60 Gy) combined with temozolomide at a dose of 75 mg/m2 per day, followed by six cycles of maintenance temozolomide (150–200 mg/m2, five consecutive days per month). The primary aim was to identify prognostic factors associated with overall survival (OS) in this cohort of patients. Results One hundred three patients were included in this study. The median age was 64 years. The median OS was 13.7 months (95% confidence interval, 12.5–15.9 months). In multivariate analysis, age over 65 years (hazard ratio [HR] = 1.88; P = 0.01), Medical Research Council (MRC) scale 3–4 (HR = 1.62; P = 0.038), and occurrence of postoperative complications (HR = 2.15; P = 0.028) were associated with unfavorable OS. Conclusions This study identified three prognostic factors in patients with glioblastoma eligible to the standard chemotherapy and radiotherapy treatment. Age over 65 years, MRC scale 3–4, and occurrence of postoperative complications were associated with unfavorable OS. A simple clinical evaluation including these three factors enables to estimate the patient prognosis. MRC neurological scale could be a useful, quick, and simple measure to assess neurological status in glioblastoma patients.
Moduli of Rank 2 Stable Bundles and Hecke Curves
Authors: Pal Sarbeswar 
Published: August 2016

AbstractLet X be a smooth projective curve of arbitrary genus g > 3 over the complex numbers. In this short note we will show that the moduli space of rank 2 stable vector bundles with determinant isomorphic to Lx , where Lx denotes the line bundle corresponding to a point x ∊ X, is isomorphic to a certain variety of lines in the moduli space of S-equivalence classes of semistable bundles of rank 2 with trivial determinant.
The Use of Evidence-Based, Problem-Oriented Templates as a Clinical Decision Support in an Inpatient Electronic Health Record System
Authors: Radhakrishnan Nila , Warring Carrie , Jain Ankur , Fuentes Jorge , Dolganiuc Angela , Lourdes Laura , Busigin John , Leverence Robert , Mehta Raj 
Published: August 2016

SummaryThe integration of clinical decision support (CDS) in documentation practices remains limited due to obstacles in provider workflows and design restrictions in electronic health records (EHRs). The use of electronic problem-oriented templates (POTs) as a CDS has been previously discussed but not widely studied.We evaluated the voluntary use of evidence-based POTs as a CDS on documentation practices.This was a randomized cohort (before and after) study of Hospitalist Attendings in an Academic Medical Center using EPIC EHRs. Primary Outcome measurement was note quality, assessed by the 9-item Physician Documentation Quality Instrument (PDQI-9). Secondary Outcome measurement was physician efficiency, assessed by the total charting time per note.Use of POTs increased the quality of note documentation [score 37.5 vs. 39.0, P = 0.0020]. The benefits of POTs scaled with use; the greatest improvement in note quality was found in notes using three or more POTs [score 40.2, P = 0.0262]. There was no significant difference in total charting time [30 minutes vs. 27 minutes, P = 0.42].Use of evidence-based and problem-oriented templates is associated with improved note quality without significant change in total charting time. It can be used as an effective CDS during note documentation.
Citation: Mehta R, Radhakrishnan NS, Warring CD, Jain A, Fuentes J, Dolganiuc A, Lourdes LS, Busigin J, Leverence RR. The use of evidence-based, problemoriented templates as a clinical decision support in an inpatient electronic health record system.
Collectief bedongen werkgelegenheidsgaranties
Authors: Zekic Nuna 
Published: August 2016

Collectief bedongen werkgelegenheidsgaranties
In het kader van collectief overleg spreken werknemersorganisaties vaak met de werkgever af dat hij gedurende een bepaalde periode geen (collectief) ontslag zal initiëren. Deze afspraken worden meestal aangeduid als werkgelegenheidsgaranties. Dit zijn dikwijls belangrijke onderwerpen bij collectieve onderhandelingen, en onenigheid hierover vormt vaak de kern van een collectief conflict. Toch is er weinig bekend over dergelijke afspraken. Het eerste deel van dit artikel heeft als doel meer inzicht te verschaffen in de inhoud en de formulering van dit soort cao-bepalingen. Het tweede deel gaat in op de vraag hoe we moeten omgaan met een werkgelegenheidsgarantie in een ontslagprocedure.
Achterstallige pensioenpremies bij overgang van onderneming
Authors: Hoppers Frederique 
Published: August 2016

Achterstallige pensioenpremies bij overgang van onderneming
Het Hof Arnhem-Leeuwarden heeft in september 2015 een arrest gewezen waarin de regels omtrent overgang van onderneming samenkomen met pensioenregels. Centraal stond de vraag of een pensioenuitvoerder een verkrijgende werkgever kan aanspreken tot betaling van achterstallige pensioenpremies. Het Hof heeft deze vraag op basis van specifieke merites bevestigend beantwoord. In de annotatie worden de overwegingen vanuit (pensioen)juridisch perspectief becommentarieerd en wordt tevens geanalyseerd wat de reikwijdte van dit arrest voor andere pensioensituaties is. Voorts wordt nagegaan of uit het arrest een algemene stelregel kan worden opgemaakt dat regels omtrent overgang van onderneming derdenwerking (kunnen) hebben.
Overgang van onderneming in de luchtvaartsector – with arms wide open?
Authors: Haanappel-van der Burg Iris 
Published: August 2016

Overgang van onderneming in de luchtvaartsector – with arms wide open?
In de zaak Ferreira da Silva e Brito e.a./Estado português heeft het Hof van Justitie in het kader van overgang van onderneming expliciet de luchtvaartsector als kapitaalintensieve sector aangewezen. Hoe verhoudt het arrest zich tot het oordeel van het Gerechtshof Amsterdam over de overgang van de passagedivisie van Martinair naar KLM? Daarnaast heeft het Hof van Justitie voor het eerst direct de rechterlijke macht aangesproken wegens het niet voldoen aan de verwijzingsplicht, reden waarom het arrest een landmark judgement is genoemd. Ten slotte heeft het Hof van Justitie zich uitgelaten over staatsaansprakelijkheid voor onrechtmatige rechtspraak, waarbij het maar zeer de vraag is of de hoge Nederlandse aansprakelijkheidsdrempel de door het Hof van Justitie herhaalde toets kan doorstaan.
Spectrofluorometric Determination of Putrescine: Optimization of the Putrescine–Orthophthaldehyde Complex Using Spectrofluorometry
Authors: Oyelakin Oladele , Traoré Moumouny , Mbye El Hadji Babacar , Khonté Abdourahmane , Cisse Lamine , Faye Abdoulaye N , Faye Ousman , Mbaye Moussa , Kital Khemesse , Gaye-Seye Mame Diabou , Coly Atanasse , Tine Alphonse , Delattre François 
Published: August 2016

Abstract
In alkaline medium, the complex formed between putrescine and orthophthalaldehyde was studied using spectrofluorescence. The derivative is kinetically stable 24 h after complexation. The stoichiometry of the complex is 1:1 at maximum fluorescence intensity, also 24 h after complexation.
Tedizolid and Linezolid for Treatment of Acute Bacterial Skin and Skin Structure Infections of the Lower Extremity versus Non–Lower-Extremity Infections
Authors: Joseph Warren S. , Culshaw Darren , Anuskiewicz Steven , De Anda Carisa , Prokocimer Philippe 
Published: August 2016

Background:
Tedizolid phosphate, the prodrug of the oxazolidinone tedizolid, has been approved in a number of countries, including the United States, those in the European Union, and Canada, for treatment of patients with acute bacterial skin and skin structure infections (ABSSSI). Two phase 3 trials demonstrated the noninferior efficacy of tedizolid (200 mg once daily for 6 days) to linezolid (600 mg twice daily for 10 days) in patients with ABSSSI. Because of the challenges of treating lower-extremity ABSSSI, the efficacy and safety of tedizolid and linezolid for treating lower-extremity versus non–lower-extremity infections were compared.

Methods:
This was a post hoc analysis of pooled data from patients with lower-extremity infections enrolled in two phase 3 studies, ESTABLISH-1 (NCT01170221) and ESTABLISH-2 (NCT01421511), comparing tedizolid to linezolid in patients with ABSSSI.

Results:
Lower-extremity ABSSSI were present in 40.7% of tedizolid-treated and 42.2% of linezolid-treated patients. Methicillin-resistant Staphylococcus aureus (MRSA) was present in 34.7% of all patients with a baseline causative pathogen. Early clinical responses at 48 to 72 hours and investigator-assessed responses at the post-therapy evaluation were similar between tedizolid and linezolid, regardless of ABSSSI type. With both treatments, the early clinical response was slightly higher in patients with non–lower-extremity infection than in those with lower-extremity ABSSSI (tedizolid, 84.8% versus 77.0%; linezolid, 81.4% versus 76.6%, respectively); however, by the post-therapy evaluation visit, response rates were similar (tedizolid, 87.1% versus 86.3%; linezolid, 86.6% versus 87.2%, respectively). Gastrointestinal adverse events and low platelet counts were observed more frequently with linezolid treatment.

Conclusions:
Post-therapy evaluations showed that the clinical response of lower-extremity ABSSSI to tedizolid and linezolid was comparable to that of ABSSSI in other locations. A short 6-day course of once-daily tedizolid was as effective as a 10-day course of twice-daily linezolid in treating patients with lower-extremity ABSSSI.
Ferroelectric phase stabilization of HfO2 by nitrogen doping
Authors: Xu Lun , Nishimura Tomonori , Shibayama Shigehisa , Yajima Takeaki , Migita Shinji , Toriumi Akira 
Published: August 2016

Abstract
We report that nitrogen (N) doping can drive the ferroelectricity of HfO2. It was found that N doping can cause the transition from a monoclinic phase to a highly symmetric phase. The role of N doping is discussed from the viewpoints of charge balance and bond-constraining effects. The former is responsible for the structural transformation from a paraelectric phase to a ferroelectric phase by forming an oxygen vacancy. In addition, Hf–N and N–O bonds with covalent characteristics have strong effects on HfO2 structural and electrical properties, and thus contribute to a marked HfO2 para-/ferroelectric transition.
Practical angular-multiplexing holographic data storage system with 2 terabyte capacity and 1 gigabit transfer rate
Authors: Hoshizawa Taku , Shimada Ken-ichi , Fujita Kouji , Tada Yukinobu 
Published: August 2016

Abstract
Aiming at the realization of an optical data storage system with a large disc capacity and a high transfer rate suitable for digital data archiving, we have defined the specifications of an angular-multiplexing holographic data storage system with a disc capacity of 2 TB and a transfer rate of 1 Gbps on the basis of a run-length-limited (RLL) high-density recording method using RLL modulation. To realize the specifications, RLL turbo coding, a servo system for the reference beam angle, and a servo system for book tracking were newly invented. Also, to satisfy the specifications, a holographic disc and several key components were developed in cooperation with several specialty companies. Eventually, we confirmed a high-density recording of 2.4 Tbit/in.2 achieved by the RLL high-density recording method, using evaluation equipment complying with the specifications for single book recording.