bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood language development and alexithymia in adolescence: an 8-year longitudinal study
Authors: Lee Ka Shu , Catmur Caroline , Bird Geoffrey 
Published: October 2024

Abstract
Alexithymia (difficulties identifying and describing feelings) predicts increased risks for psychopathology, especially during the transition from childhood to adolescence. However, little is known of the early contributors to alexithymia. The language hypothesis of alexithymia suggests that language deficits play a primary role in predisposing language-impaired groups to developing alexithymia; yet longitudinal data tracking prospective relationship between language function and alexithymia are scarce. Leveraging data from the Surrey Communication and Language in Education cohort (N = 229, mean age at time point 1 = 5.32 years, SD = 0.29, 51.1% female), we investigated the prospective link between childhood language development and alexithymic traits in adolescence. Results indicated that boys with low language function at ages 4–5 years, and those who later met the diagnostic criteria for language disorders at ages 5–6 years, reported elevated alexithymic traits when they reached adolescence. Parent-reported child syntax abilities at ages 5–6 years revealed a dimensional relationship with alexithymic traits, and this was consistent with behavioral assessments on related structural language abilities. Empirically derived language groups and latent language trajectories did not predict alexithymic traits in adolescence. While findings support the language hypothesis of alexithymia, greater specificity of the alexithymia construct in developmental populations is needed to guide clinical interventions.
Community-engaged research: Bringing the science of developmental psychopathology into the real world
Authors: Parade Stephanie H. , Jennings Ernestine , Huffhines Lindsay , Rojo-Wissar Darlynn M. , Caron Colleen , Berger Blythe , Stroud Laura R. , Tyrka Audrey R. 
Published: October 2024

AbstractThe science of developmental psychopathology has made outstanding progress over the past 40 years in understanding adaptive and maladaptive developmental processes across the life span. Yet most of this work has been researcher driven with little involvement of community partners in the research process, limiting the potential public health significance of our work. To continue to advance the field we must move beyond the physical and conceptual walls of our research laboratories and into the real world. In this article, we define and describe the importance of community-engaged research, and present our overarching principles for engaging the community including practicing respect, shared power and decision-making, prioritizing the needs of the community, and engaging in consistent and transparent communication. We present several associated recommendations for best practice and highlight examples from our own research that is grounded in a developmental psychopathology perspective to illustrate these practices. Recommendations for the future of the discipline of development and psychopathology, with emphasis on training and continuing education, are described.
Profiles of self-regulation and their association with behavior problems among sexually abused children
Authors: Amédée Laetitia Mélissande , Cyr Chantal , Hébert Martine 
Published: October 2024

Abstract
This study aimed to delineate profiles of self-regulation among sexually abused children and their association with behavior problems using a person-centered approach. A sample of 223 children aged six to 12, their parents, and teachers were recruited in specialized intervention centers. Latent profile analysis revealed four profiles: (1) Dysregulated, (2) Inhibited, (3) Flexibly Regulated, and (4) Parent Perceived Self-Regulation. Children from the Flexibly Regulated profile showed relatively low behavior problems, and those from the Dysregulated profile were characterized by high behavior problems. Children from the Parent Perceived Self-Regulation profile showed overall good adaptation, although teachers reported higher behavior problems than parents. Children from the Inhibited profile, characterized by the highest level of inhibition but low parent-rated emotion regulation competencies and executive functions, showed the highest level of internalizing behavior problems, indicating that high inhibition does not necessarily translate to better adaptation. Results also show a moderation effect of sex. Being assigned to the Inhibited profile was associated with decreased externalizing behaviors in boys and increased internalizing behaviors in girls. This study underscores the complexity of self-regulation in sexually abused children and supports the need to adopt a multi-method and multi-informant approach when assessing these children.
Snake queens and political consolidation: How royal women helped create Kaan: A view from Waka’
Authors: Navarro-Farr Olivia C. , Kelly Mary Kate , Freidel David A. 
Published: October 2024

AbstractClassic Maya history was rife with shifting political coalitions and disputes with the key antagonists, Tikal and the Kaan regime, at the center. Understanding how power dynamics and political shifts were experienced among subordinate polities is best viewed from multiple perspectives. We employ elements of Graeber and Sahlins' (2017) stranger-king model, focusing on exogamous marriage practices in relation to two Snake Queens ruling at Waka’. They served as direct links between the Kaan regime and the subordinate Wak polity. We focus on the political and diplomatic nature of their roles in crafting Waka's place in the overarching narratives of alliance and conquest during the sixth through the early part of the eighth centuries. The pairing of archaeological and textual data surrounding Ix Ikoom in the sixth century and Lady K'abel during the seventh century permit interrogation of women's prominence with respect to Kaan regime-building strategies during these centuries.
Psychometric properties of the Turkish version of the developmental care scale for neonates with congenital heart disease
Authors: Sevgi Seçkin Kolak , Ayşe Kahraman 
Published: October 2024

AbstractObjective:Developmental care for newborns with congenital heart disease (CHD) improves cardiac and respiratory patterns. According to the American Heart Association, developmental care in newborns with CHD is important for improving neurodevelopmental outcomes. This study aimed to evaluate the validity and reliability of the Turkish version of the Developmental Care Scale for Neonates with Congenital Heart Disease.Methods:This was a methodological, descriptive study conducted with 169 nurses from a tertiary-level NICU. The Demographical Information Form and the Developmental Care Scale for Neonates with Congenital Heart Disease were used to collect the data. The scales’ language and content validity, construct validity, and internal consistency were also assessed.Results:The scale consists of 31 items and four subscales. Factor loadings ranged from 0.44 to 0.82 and explained 65% of the total variance. Fit indices indicate that the model is acceptable. Cronbach’s α was 0.95 for the entire instrument, 0.91 for developing the external environment subscale, 0.94 for assessing family well-being, 0.86 for the caregiver activities toward the neonate, and 0.82 for the basic need subscale. Item–total correlations ranged between 0.34 and 0.75, according to the item analysis results.Conclusions:The Turkish version of the Developmental Care Scale for Neonates with Congenital Heart Disease is valid and reliable. The use of this scale could improve the performance of neonatal intensive care nurses in providing developmental care to newborns with CHD as well as the quality of care.
Concurrent validity of inertial measurement units in range of motion measurements of upper extremity: A systematic review and meta-analysis
Authors: Li Jinfeng , Qiu Fanji , Gan Liaoyan , Chou Li-Shan 
Published: October 2024

Abstract
Inertial measurement units (IMUs) have proven to be valuable tools in measuring the range of motion (RoM) of human upper limb joints. Although several studies have reported on the validity of IMUs compared to the gold standard (optical motion capture system, OMC), a quantitative summary of the accuracy of IMUs in measuring RoM of upper limb joints is still lacking. Thus, the primary objective of this systematic review and meta-analysis was to determine the concurrent validity of IMUs for measuring RoM of the upper extremity in adults. Fifty-one articles were included in the systematic review, and data from 16 were pooled for meta-analysis. Concurrent validity is excellent for shoulder flexion–extension (Pearson’s r = 0.969 [0.935, 0.986], ICC = 0.935 [0.749, 0.984], mean difference = −3.19 (p = 0.55)), elbow flexion–extension (Pearson’s r = 0.954 [0.929, 0.970], ICC = 0.929 [0.814, 0.974], mean difference = 10.61 (p = 0.36)), wrist flexion–extension (Pearson’s r = 0.974 [0.945, 0.988], mean difference = −4.20 (p = 0.58)), good to excellent for shoulder abduction–adduction (Pearson’s r = 0.919 [0.848, 0.957], ICC = 0.840 [0.430, 0.963], mean difference = −7.10 (p = 0.50)), and elbow pronation–supination (Pearson’s r = 0.966 [0.939, 0.981], ICC = 0.821 [0.696, 0.900]). There are some inconsistent results for shoulder internal–external rotation (Pearson’s r = 0.939 [0.894, 0.965], mean difference = −9.13 (p < 0.0001)). In conclusion, the results support IMU as a viable instrument for measuring RoM of upper extremity, but for some specific joint movements, such as shoulder rotation and wrist ulnar-radial deviation, IMU measurements need to be used with caution.
Projecting Future Mercury Emissions From Global Biofuel Combustion Under the Carbon Neutrality Target
Authors: Wang Tengjiao , Xin Yu , Du Huarui , Cui Can , Li Jiashuo , Liu Xi 
Published: October 2024

AbstractBiomass plays a crucial role in the low‐carbon energy transition, with a projected contribution of 18.7% to the global energy supply by 2050. However, biofuel combustion has been a notable source of toxic mercury emissions, yet the future trends and distribution of the emissions remain inadequately understood. Here, we projected biofuel combustion under various Shared Socioeconomic Pathways (SSPs) using the Global Change Assessment Model and assessed associated mercury emissions in cooking, heating, and power generation over 2020–2050, aligning with the carbon neutrality target. Our analysis reveals that global biofuel mercury emissions are projected to be 9.90–18.40 tons by 2050, compared to the annual emissions of 13.89 tons in 2020. Notably, a substantial increase in emissions from power generation is expected, escalating from 0.57 tons in 2020 to 4.69–8.27 tons by 2050, with China and Southeast Asia emerging as primary contributors. Conversely, mercury emissions from cooking and heating are expected to decrease from 13.32 tons in 2020 to 4.40–11.53 tons by 2050, except in Africa under SSP2, where the emissions may increase from 5.91 to 6.69 tons. Our findings provide a scientific basis for policies aimed at achieving carbon neutrality targets while adhering to the Minamata Convention on Mercury.
Wave‐Influenced Delta Morphodynamics, Long‐Term Sediment Bypass and Trapping Controlled by Relative Magnitudes of Riverine and Wave‐Driven Sediment Transport
Authors: Zăinescu F. , Storms J. E. A. , Vespremeanu‐Stroe A. , Van Der Vegt H. , Schuster M. , Anthony E. 
Published: October 2024

AbstractRiver sediment supply (Qs) and longshore sediment transport (LST) are recognized as two paramount controls on river delta morphodynamics and stratigraphy. We employed the Delft3D model to simulate the evolution of deltas from fluvial to wave‐dominated conditions, revealing the interplay between river‐ and wave‐driven sediment quantities. Wave‐influenced deltas may show alternating accumulation and retreat patterns driven by avulsions and wave‐induced sediment diffusion, posing coastal management challenges. Deltas with higher wave energy evolve under a fine balance between river supply and intense wave‐mediated sediment redistribution and are highly vulnerable under conditions of sediment reduction. Reducing Qs by ∼40%–70%, common in modern dammed rivers, can rapidly shift bypass from ∼0 to 1 (no bypass to complete bypass). This leads to accelerated diffusion and potential sediment loss in modern deltas. The study highlights the importance of accurately computing sediment quantities in real‐world deltas for improved management, especially under increasing anthropogenic and climatic pressures.
Sediment Corrections for Distributed Acoustic Sensing
Authors: Trabattoni Alister , Vernet Clara , van den Ende Martijn , Baillet Marie , Potin Bertrand , Rivet Diane 
Published: October 2024

AbstractOn continental margins, sediments cause significant and spatially variable delays in seismic phase arrival times. The strong impedance contrast of the sediment‐bedrock interface causes P‐wave splitting that is clearly seen on distributed acoustic sensing recordings of earthquakes, resulting in additional phase arrivals that must be picked separately. We introduce sediment corrections to correctly account for those additional phases in the hypocenter localization procedure. Conceptually, the sediment correction method differs from the commonly‐used station corrections; instead of introducing a mathematically optimal constant time delay for each station and each phase, the corrections are derived from a physical, first‐order modeling of the wave propagation in the sediments. To calibrate the sediment corrections, a two‐step procedure is adopted: (a) the delay between the P‐phase and the converted Ps‐phase is taken as a proxy of the sediment thickness; (b) the P‐ and S‐wave speeds are determined through inversion. We show that sediment corrections are able to account for most of the observed bias while considerably reducing the number of free parameters compared to classical station correction. Moreover, the observed local delays are almost fully explained by the presence of the sedimentary layer, rather than by the 3D velocity variations of the bedrock. We retrieve and values that are compatible with values commonly found for sediments. Given the simplicity and physical foundation of the proposed method, we recommend the use of sediment corrections over station corrections whenever significant P‐wave splitting can be observed.
Historical Trends in Ocean Heat, Carbon, Salinity, and Oxygen Simulations: Impact of a Changing Ocean Transport
Authors: Mannis Scott , Waugh Darryn W. , Gnanadesikan Anand , Haine Thomas W. N. 
Published: October 2024

AbstractExamination of historical simulations from CMIP6 models shows substantial pre‐industrial to present‐day changes in ocean heat (ΔH), salinity (ΔS), oxygen (ΔO2), dissolved inorganic carbon (ΔDIC), chlorofluorocarbon‐12 (ΔCFC12), and sulfur hexafluoride (ΔSF6). The spatial structure of the changes and the consistency among models differ among tracers: ΔDIC, ΔCFC12, and ΔSF6 all are largest near the surface, are positive throughout the thermocline with weak changes below, and there is good agreement among the models. In contrast, the largest ΔH, ΔS, and ΔO2 are not necessarily at the surface, their sign varies within the thermocline, and there are large differences among models. These differences between the two groups of tracers are linked to climate‐driven changes in the ocean transport, with this tracer “redistribution” playing a significant role in changes in ΔH, ΔS, and ΔO2 but not the other tracers. The spatial structure, and differences between models, of changes in age tracers are consistent with ΔH, ΔS, and ΔO2, supporting the hypothesis that redistribution plays a major role for these tracers. Further, the impact of the vertical displacement of isopycnals (heave) plays a major role in the differing impact of redistribution between the two groups, with this process causing insignificant changes to ΔDIC, ΔCFC12, and ΔSF6 due to their weak spatial gradients. A similar multi‐tracer analysis of observations could provide insights into the relative role of the addition and redistribution of tracers in the ocean.
Evaluating the Importance of Nitrate‐Containing Aerosols for the Asian Tropopause Aerosol Layer
Authors: Zhu Yunqian , Yu Pengfei , Wang Xinyue , Bardeen Charles , Borrmann Stephan , Höpfner Michael , Mahnke Christoph , Weigel Ralf , Krämer Martina , Deshler Terry , Bian Jianchun , Bai Zhixuan , Vernier Hazel , Portmann Robert W. , Rosenlof Karen H. , Kloss Corinna , Pan Laura L. , Smith Warren , Honomichl Shawn , Zhang Jun , Stone Kane A. , Toon Owen Brian 
Published: October 2024

AbstractThe Asian Summer Monsoon (ASM) convection transports aerosols and their precursors from the boundary layer to the upper troposphere and lower stratosphere (UTLS). This process forms an annually recurring aerosol layer near the tropopause. Recent observations have revealed a distinct property of the aerosol layer over the ASM region, it is nitrate‐rich. We present a newly implemented aerosol formation algorithm that enhances the representation of nitrate aerosol in the Community Aerosol and Radiation Model for Atmospheres (CARMA) coupled with the Community Earth System Model (CESM). The simulated aerosol chemical composition, as well as vertical distributions of aerosol size and mass, are evaluated using in situ and remote sensing observations. The simulated concentrations (ammonium, nitrate, and sulfate) and size distributions are generally within the error bars of data. We find nitrate, organics, and sulfate contribute significantly to the UTLS aerosol concentration between 15°–45°N and 0°–160°E. The two key formation mechanisms of nitrate‐containing aerosols in the ATAL are ammonium neutralization to form ammonium nitrate in regions where convection is active, and condensation of nitric acid in regions of cold temperature. Furthermore, including nitrate formation in the model doubles the surface area density in the tropical tropopause region between 15°–45°N and 0°–160°E, which alters the chlorine partitioning and subsequently impacts the rate of ozone depletion.
Response of the Thermosphere‐Ionosphere System to an X‐Class Solar Flare: 30 March 2022 Case Study
Authors: Sarp Volkan , Yiğit Erdal , Kilcik Ali 
Published: October 2024

AbstractThe response of the thermosphere ionosphere system to an X1.3 class solar flare is studied using observations of the total electron content (TEC) and the Global Ionosphere Thermosphere Model (GITM) simulations. The solar flare erupted from the active region AR12975 on 30 March 2022. Owing to the absence of accompanying severe geomagnetic activity, it was possible to isolate the effects of the flare on the upper atmosphere. TEC data are processed for Continental USA (CONUS), employing filtering and binning techniques to create 2D variation maps. The spectral content of the TEC variations is analyzed using a wavelet coherence method. The immediate response of the solar flare exhibited broad similarities, while notable differences were observed during the recovery period between the East and West sides of the CONUS. GITM is used to explore the East–West asymmetry of the key T‐I parameters. Simulation results reveal that the coinciding interplanetary magnetic field southward turning had a greater influence on these parameters compared to the solar flare, while their nonlinear interaction introduced complex variations. Additional investigation reveals gravity wave damping also contributes to the asymmetric solar flare response.
Melanoma-specific mutation hotspots in distal, non-coding, promoter-interacting regions implicate novel candidate driver genes
Authors: Pudjihartono Michael , Pudjihartono Nicholas , O’Sullivan Justin M. , Schierding William 
Published: October 2024

Abstract
Background
To develop targeted treatments, it is crucial to identify the full spectrum of genetic drivers in melanoma, including those in non-coding regions. However, recent efforts to explore non-coding regions have primarily focused on gene-adjacent elements such as promoters and non-coding RNAs, leaving intergenic distal regulatory elements largely unexplored.

Methods
We used Hi-C chromatin contact data from melanoma cells to map distal, non-coding, promoter-interacting regulatory elements genome-wide in melanoma. Using this “promoter-interaction network”, alongside whole-genome sequence and gene expression data from the Pan Cancer Analysis of Whole Genomes, we developed multivariate linear regression models to identify distal somatic mutation hotspots that affect promoter activity.

Results
We identified eight recurrently mutated hotspots that are novel, melanoma-specific, located in promoter-interacting distal regulatory elements, alter transcription factor binding motifs, and affect the expression of genes (e.g., HSPB7, CLDN1, ADCY9 and FDXR) previously implicated as tumour suppressors/oncogenes in various cancers.

Conclusions
Our study suggests additional non-coding drivers beyond the well-characterised TERT promoter in melanoma, offering new insights into the disruption of complex regulatory networks by non-coding mutations that may contribute to melanoma development. Furthermore, our study provides a framework for integrating multiple levels of biological data to uncover cancer-specific non-coding drivers.
CircGSK3β mediates PD-L1 transcription through miR-338-3p/PRMT5/H3K4me3 to promote breast cancer cell immune evasion and tumor progression
Authors: Liang Lin , Gao Mengxiang , Li Wentao , Tang Jingqiong , He Qian , Zeng Feng , Cao Jiaying , Liu Siyi , Chen Yan , Li Xin , Zhou Yanhong 
Published: October 2024

AbstractCircular RNA (circRNA) plays a pivotal role in breast cancer onset and progression. Understanding the biological functions and underlying molecular mechanisms of dysregulated circRNAs in breast cancer is crucial for elucidating its pathogenesis and identifying potential therapeutic targets. In this study, we investigated the role and molecular mechanism of circGSK3β in breast cancer. We found that circGSK3β is highly expressed in breast cancer cell lines, where it promotes cell proliferation, migration, and invasion, thereby driving breast cancer progression. Furthermore, we observed a close association between circGSK3β expression levels and immune evasion in breast cancer cells. Mechanistically, circGSK3β acts as a competing endogenous RNA (ceRNA) by interacting with miR-338-3p, thereby promoting breast cancer cell proliferation, migration, and invasion. Additionally, circGSK3β positively regulates the expression of the target gene PRMT5 through its interaction with miR-338-3p. This, in turn, enhances H3K4me3 recruitment to the promoter region of PD-L1, resulting in upregulation of PD-L1 expression and consequent immune evasion in breast cancer. In summary, our findings underscore the significance of the circGSK3β-miR-338-3p-PRMT5-H3K4me3 axis in promoting breast cancer progression and immune evasion. CircGSK3β emerges as a critical player in breast cancer pathogenesis, potentially serving as a diagnostic and prognostic marker, and offering novel insights into the role of circRNAs in breast cancer progression.