bluuebunny/crossref_metadata_2025_split huggingface dataset:
C677T and A1298C polymorphisms of methylene tetrahydrofolate reductase in non-Hodgkin lymphoma: southeast Iran
Authors: Mashhadi Mohammad Ali , Miri-Moghaddam Ebrahim , Arbabi Narges , Bazi Ali , Heidari Zahra , Sepehri Zahra , Karimkoshte Azra , Rezvan Alireza , Hashemi Seyed Mahdi 
Published: April 2017

Purpose: Polymorphisms of the methylene tetrahydrofolate reductase (MTHFR) gene have been reported as risk factors for non-Hodgkin lymphoma (NHL) in some populations. Our goal was to evaluate the potential role of A1298C and C677T polymorphisms of MTHFR in risk of NHL in southeast Iran. Methods: In the present case-control study, 127 patients with newly diagnosed NHL along with 150 ethnicity- and age-matched controls were examined. The A1298C and C677T polymorphisms were genotyped using the Tetra Amplification Refractory Mutation System polymerase chain reaction method. Results: There were no significant differences in genotype frequencies between cases and controls regarding either A1298C polymorphism. For this polymorphism, 53.8% of the controls and 54.3% of the patients with NHL showed homozygous wild-type (AA) genotype. Variant 1298C allele was recognized with overall frequency of 34.6% in both groups. Frequencies of CC, CT, and TT genotypes of C677T polymorphism were observed in 73.1%, 25.8%, and 1.3% of the controls, and 64.5%, 33.1%, and 2.4% of the patients with NHL (p>0.05). In combination, CT + TT conferred a significantly higher risk of NHL (odds ratio [OR] 1.5, 95% confidence interval [CI] 0.9-2.4, p = 0.03). Overall, variant 677T allele presented with higher frequency in the patients with NHL than the controls (26.7% versus 21.3%, respectively; OR 1.3, 95% CI 0.8-2.1, p>0.05). Although statistically insignificant, the highest risk of NHL was identified in patients with C677T; A1298C: CT; CC haplotype (OR 4.7, 95% CI 0.4-46.4, p = 0.1). Conclusions: Combination of CT and TT genotypes of C677T polymorphism conferred a significantly higher risk for NHL. It is recommended to investigate further the potential role of this polymorphism in NHL development.
Discrete Time Hazard Modeling of Large Motor Carriers' Longitudinal Safety Performance
Authors: Miller Jason 
Published: April 2017

AbstractMultiple stakeholders have a vested interest in motor-carrier safety because it affects the welfare of the general public and companies' supply chain operations. This article develops new theory about motor carrier safety by utilizing processes from attention-based theory and new institutional theory to answer questions regarding carrier safety since the rollout of the Compliance, Safety, and Accountability (CSA) program. This research examines the propensity that carriers flagged for poor performance on hours-of-service (HOS) compliance when the program was fully implemented in late 2010 exited this status at least once during the subsequent 3.5 years. Conversely, it examines whether carriers not flagged for poor HOS performance at the start of the program come to receive a safety warning at least once during the subsequent 3.5 years. It further examines how carrier size affects these respective hazard rates. Hypothesized effects are tested using panel data from N = 484 large, for-hire carriers by fitting a series of discrete time hazard models. The results are consistent with the theory put forward. The article concludes by describing theoretical contributions, explaining managerial and public policy implications, noting limitations, and making recommendations for further inquiry.
Evaluating the Impact of Spatio-Temporal Factors on Construction Heuristics for Transportation Services
Authors: Mian Adnan Noor , Fahim Amina , Hameed Abdul 
Published: April 2017

Abstract
In the dial-a-ride services, customers specify pickup and drop-off locations and their times for transport. The operator aims at constructing cheap itineraries while minimizing customer inconvenience. This problem has been studied as the Dial-a-Ride Problem (DARP), which consists of both spatial and temporal factors. This article studies the impact of spatial and temporal variation on multivehicle DARP using route construction heuristics. Our work highlights the impact of these variations on the customer disutility and transportation cost. The study will help the service operators in selecting an appropriate construction heuristic while expanding the DARP service in terms of service area, service duration, or planning for a sudden growth in the number of customers. The results show that if the operator is planning to expand the area of service, the Saving Heuristic is more appropriate for larger operators while Insertion Heuristic with spatial sorting scheme is better for smaller operators with limited number of vehicles. If the operator is expanding the service in terms of service duration, from 8 to 24 hours daily, for instance, or preparing for a growth in the number of customers, the Saving Heuristic is better for both smaller and larger service operators.
Een moeilijke missie: een analyse van de nieuwe Europese grens- en kustwacht
Authors: Kok S.G. 
Published: April 2017

Een moeilijke missie: Een analyse van de nieuwe Europese grens- en kustwacht
De Verordening voor een Europese grens- en kustwacht van 2016 introduceert het concept van een geïntegreerd grensbeheer. De Europese Unie heeft hierdoor mogelijkheden om te interveniëren wanneer lidstaten de buitengrenzen onvoldoende bewaken. De Europese grens- en kustwacht gaat echter nog steeds uit van uitvoering van de grensbewaking door de lidstaten zelf. De lidstaten kunnen bijstand ontvangen door grensbewakings- en terugkeeroperaties. Deze worden gecoördineerd door het Frontex-agentschap en uitgevoerd door nationale ambtenaren van de lidstaten. Deze constructie kan leiden tot complexe vragen over aansprakelijkheden en bevoegdheden, zeker op een politiek beladen terrein waar mensenrechten onder druk (kunnen) staan.Verordening (EU) 2016/1624 tot wijziging van Verordening (EU) 2016/399 van het Europees Parlement en de Raad en tot intrekking van Verordening (EG) nr. 863/2007, Verordening (EG) nr. 2007/2004 van de Raad en Besluit 2005/267/EG van de Raad, PbEU 2016, L 251/1
GS Media/Sanoma: oppassen met bedrijfsmatig linken
Authors: Haak M.F.J. , Truijens M.M. 
Published: April 2017

GS Media/Sanoma: oppassen met bedrijfsmatig linken
Het plaatsen van een hyperlink naar illegale content kan onder omstandigheden gelden als ‘mededeling aan het publiek’ als bedoeld in artikel 3 lid 1 van de Auteursrechtrichtlijn, en kan dus als auteursrechtinbreuk worden aangemerkt. Dat volgt uit dit arrest van het Hof van Justitie inzake GS Media/Sanoma, beter bekend als het arrest over de naaktfoto’s van BN’er Britt Dekker.HvJ 8 september 2016, zaak C-160/15, GS Media BV/Sanoma Media Netherlands BV e.a., ECLI:EU:C:2016:644
De spannende kennismaking tussen staatssteun en voetbal onderzocht
Authors: Khatib A.A. 
Published: April 2017

De spannende kennismaking tussen staatssteun en voetbal onderzocht
In 2013 begon de Europese Commissie een onderzoek naar staatssteun aan verschillende voetbalclubs in Nederland en Spanje. Dit onderzoek is op 4 juli 2016 tot een einde gekomen. De Europese Commissie oordeelt dat de steunmaatregelen ten gunste van de Nederlandse voetbalclubs geen of verenigbare staatssteun behelzen. De Spaanse voetbalclubs moeten echter substantiële bedragen terugbetalen omdat de Europese Commissie concludeert dat zij onverenigbare staatssteun hebben ontvangen. Europese Commissie 4 juli 2016, SA.40168 (Willem II), SA.41612 (MVV), SA.41614 (Den Bosch), SA.41617 (NEC) en SA.41613 (PSV) Europese Commissie 4 juli 2016, SA.29769 (Real Madrid CF, FC Barcelona, Athletic Club Bilbao, Atlético Osasuna), SA.33754 (Real Madrid) en SA.36387 (Valencia, Hercules en Elche).
Blocking methods to prevent non-specific adhesion of mesenchymal stem cells to titanium and evaluate the efficiency of surface functionalization: albumin vs poly(ethylene glycol) coating
Authors: Fraioli Roberta , Manero Planella José María , Gil Mur Francisco Javier , Mas Moruno Carlos 
Published: April 2017

Surface modification of biocompatible materials with biologically-active molecules is a well-known strategy to enhance the osteointegration of implantable devices. In order to evaluate the efficiency of these treatments, an in vitro study of cell behavior on the modified surface is usually carried out. A key point to evaluate the efficacy of this strategy is to avoid non specific protein adsorption by creating a non-fouling background. This blocking step ensures that the observed response of cells can be exclusively ascribed to the modification treatment applied. Several techniques are available to create this neutral background. Thus, the aim of this study is to compare two different blocking methods, namely adsorption of albumin from bovine serum (BSA) and grafting of small polyethylene glycol (PEG) chains to titanium, which is the gold standard metal for orthopedics and dentistry. To this end, titanium surfaces were coated with a recently synthesized cell adhesive peptide-based molecule and subjected to a blocking procedure with either BSA or PEG. Non-functionalized titanium samples were also blocked and used as controls. The biological response of human mesenchymal stem cells was evaluated by measuring the number of attached cells and studying the degree of cell spreading on the substrate. Both aspects of cell behavior are not affected significantly by the blocking method: cells adhere and spread significantly more on the functionalized samples, regardless of the blocking method used. This confirms that the surface feature that defines cell response is the presence/absence of the biomolecule, and not the anti-fouling layer. These results, together with the reduction of variability of results observed in presence of a blocking layer, demonstrate the efficacy and necessity of blocking the surface. PEG grafting is demonstrated as effective as BSA coating in reducing non-specific interactions and not hindering the effect of the biomolecule. However, taken into account the numerous advantages of a synthetic and customizable polymer chain over a complex natural protein, PEG blocking stands out as a very good alternative to albumin adsorption.
Primary Production of Phytoplankton from Santa Cruz Channel.
Authors: PASSAVANTE José Zanon De Oliveira 
Published: April 2017

This paper reports the results of primary production phytoplankton measured from March, 1976 to June, 1977 at five stations located along the estuarine system of the Santa Cruz Channel, NortheasternBrazil. The values were between 0.94 and 76.59mg.C.h-1.m-3. The seasonal pattern observed at each station is presented and discussed, in relation to some available environmental factors.
Influence of the industrial port complex of Suape (Western Tropical Atlantic) on the biodiversity and biomass of Phaeophyceae.
Authors: REIS Thiago Nogueira de Vasconcelos , GUIMARÃES-BARROS Nathalia Cristina , VASCONCELOS Edson Regis Tavares Pessoa Pinho de , COCENTINO Adilma De Lourdes Montenegro , FUJII Mutue Toyota 
Published: April 2017

Esta pesquisa teve como objetivo principal conhecer a diversidade e distribuição espacial da biomassa de Phaeophyceae nos recifes da região portuária de Suape (Pernambuco, Brasil). O material estudado foi coletado em 6 (seis) estações fixas, em duas etapas, uma entre 1996 e 1999 e outra nos meses de Janeiro e julho de 2009 (período seco e chuvoso respectivamente), demarcadas em função da topografia e distância do Porto. No laboratório, as amostras foram triadas e fixadas em formol a 4%, neutralizadas com bórax. A identificação taxonômica baseou-se na observação da morfologia externa e interna. Foi observada, ainda, a distribuição espacial das espécies nas faixas de maré e a associação com outras algas. Foram identificados 27 táxons pertencentes a 5 ordens (Ectocarpales, Scytosiphonales, Dictyotales e Fucales) e a 6 famílias (Chnoosporaceae, Ectocarpaceae, Scytosiphonaceae, Dictyotaceae e Sargassaceae). Através da análise de similaridade foi possível observar dois grupos distintos em função da proximidade do Porto, esses dados também foram corroborados pela Permanova. A biomassa das espécies de Phaeophyceae variou de 0.001 ± 0.01 (rainy season) to 77.410 ± 3.87 g. m-2 (dry season), sendo a maior contribuição para essa biomassa o peso das espécies de Sargassum. A diversidade de Phaeophyceae da região foi baixa, e diminuiu com a proximidade do porto e com o período chuvoso. A área pode ser considerada resiliente pois apesar dos impactos existentes, as espécies de Phaeophyceae estão bem representadas, o que indica uma grande capacidade de recuperação do ecossistema, tendo em vista mais de 30 anos de implantação do Porto. Palavras-chave: Macroalgas, Phaeophyceae, recifes, complexo portuário, Suape.
Algumas Condições Oceanográficas na Área Nordeste de Natal.
Authors: OKUDA Taizo , CAVALCANTI Lourinaldo Barreto 
Published: April 2017

Como parte da série de trabalhos Oceanográficos nas águas costeiras do Brasil, um cruzeiro de observação foi feito, em Setembro de 1960, pelo Navio Oc. "ALMIRANTE SALDANHA" da Marinha Brasileira, no qual os autores foram convidados a participar.A existência de ilhas e rochedos, na área observada, ocasionam algumas complicadas condições hidrográficas tais como ressurgência e convergência.A distribuição dos micro-nutritivos, tais como, Fosfato-P, Total-P, Nitrato-N, Nitrito-N e Amônio-N são discutidas em relação com as condições físicas gerais.Alguns aspectos de oceanografia física e química, nesta região, são descritos, através de uma comparação com os resultados obtidos em investigações anteriores, feitas em Outubro de 1959, (Okuda 1960).Foi notável que a média de relações de N/P e de O'2-O2P na água, em profundidades além de 200 metros, mostrou valores aproximadamente uniformes, e não muita diferença entre os dois anos.
Nota Sobre as Condições Hidrográficas no Açude Acari - R. G. do Norte.
Authors: OKUDA Taizo , PEREIRA Valnê Xavier , TEIXEIRA Helder 
Published: April 2017

Uma reprodução em massa de fitoplâncton verde causou à morte de considerável quantidade de peixes no Açúde MARECHAL DUTRA - em Agosto - Setembro de 1960. Em Outubro, uma observação foi feita com o objetivo de apurar a causa daquele fenômeno. Entretanto, nesta época, a reprodução já havia diminuido, não afetando mais a vida dos peixes, dificultando assim a obtenção de conclusões mais concretas.A presente nota é um estudo preliminar sobre a relação entre as condições hidrográficas e a distribuição do fitoplâncton na área do Açúde "MARECHAL DUTRA".
One possible uncertainty in CMIP5 projections of low‐oxygen water volume in the Eastern Tropical Pacific
Authors: Shigemitsu M. , Yamamoto A. , Oka A. , Yamanaka Y. 
Published: April 2017

AbstractUsing the results from nine Earth system models submitted to the Coupled Model Intercomparison Project Phase 5 (CMIP5), we identify the Eastern Tropical Pacific (ETP) as the region with the greatest uncertainty of future changes in oxygen‐deficient (<30 μM) water volumes since different models variously project both positive and negative changes in the oxygen‐deficient volume and export flux there. We investigate the factors controlling future changes in oxygen‐deficient volume in the ETP with global warming using a single off‐line biogeochemical model. Oxygen budget analysis clarifies that the Equatorial Undercurrent (EUC) is the key mechanism controlling future variations in the oxygen‐deficient volume in the ETP in our model. From the outputs of all of the CMIP5 models and our model, we identify a significant negative relationship between changes in the EUC volume transport and the oxygen‐deficient water volume from the present to the end of the 21st century, which indicates that the response of the EUC to global warming leads to one possible uncertainty in future projections of oxygen‐deficient volume in the ETP.
Subducted oceanic relief locks the shallow megathrust in central Ecuador
Authors: Collot Jean‐Yves , Sanclemente Eddy , Nocquet Jean‐Mathieu , Leprêtre Angélique , Ribodetti Alessandra , Jarrin Paul , Chlieh Mohamed , Graindorge David , Charvis Philippe 
Published: April 2017

AbstractWhether subducted oceanic reliefs such as seamounts promote seismic rupture or aseismic slip remains controversial. Here we use swath bathymetry, prestack depth‐migrated multichannel seismic reflection lines, and wide‐angle seismic data collected across the central Ecuador subduction segment to reveal a broad ~55 km × 50 km, ~1.5–2.0 km high, low height‐to‐width ratio, multipeaked, sediment‐bare, shallow subducted oceanic relief. Owing to La Plata Island and the coastline being located, respectively, ~35 km and ~50–60 km from the trench, GPS measurements allow us to demonstrate that the subducted oceanic relief spatially correlates to a shallow, ~80 km × 55 km locked interplate asperity within a dominantly creeping subduction segment. The oceanic relief geometrical anomaly together with its highly jagged topography, the absence of a subduction channel, and a stiff erosive oceanic margin are found to be long‐term geological characteristics associated with the shallow locking of the megathrust. Although the size and level of locking observed at the subducted relief scale could produce an Mw >7+ event, no large earthquakes are known to have happened for several centuries. On the contrary, frequent slow slip events have been recorded since 2010 within the locked patch, and regular seismic swarms have occurred in this area during the last 40 years. These transient processes, together with the rough subducted oceanic topography, suggest that interplate friction might actually be heterogeneous within the locked patch. Additionally, we find that the subducted relief undergoes internal shearing and produces a permanent flexural bulge of the margin, which uplifted La Plata Island.
Sea ice growth rates from tide‐driven visible banding
Authors: Turner Kate E. , Smith Inga J. , Tison Jean‐Louis , Verbeke Véronique , McGuinness Mark , Ingham Malcolm , Vennell Ross , Trodahl Joe 
Published: April 2017

AbstractIn this paper, periodic tide‐current‐driven banding in a sea‐ice core is demonstrated as a measure of the growth rate of first‐year sea ice at congelation‐ice depths. The study was performed on a core from the eastern McMurdo Sound, exploiting the well‐characterized tidal pattern at the site. It points the way to a technique for determining early‐season ice growth rates from late‐season cores, in areas where under ice currents are known to be tidally dominated and the ice is landfast, thus providing data for a time of year when thin ice prevents direct thickness (and therefore growth rate) measurements. The measured results were compared to the growth‐versus‐depth predicted by a thermodynamic model.
Persistence of bubble outlets in soft, methane‐generating sediments
Authors: Scandella Benjamin P. , Delwiche Kyle , Hemond Harold F. , Juanes Ruben 
Published: April 2017

AbstractSediments submerged beneath many inland waterways and shallow oceans emit methane, a potent greenhouse gas, but the magnitude of the methane flux to the atmosphere remains poorly constrained. In many settings, the majority of methane is released through bubbling, and the spatiotemporal heterogeneity of this ebullition both presents challenges for measurement and impacts bubble dissolution and atmospheric emissions. Here we present laboratory‐scale experiments of methane ebullition in a controlled incubation of reconstituted sediments from a eutrophic lake. Image analysis of a 0.14 m2 sediment surface area allowed identification of individual bubble outlets and resolved their location to ∼1 cm. While ebullition events were typically concentrated in bursts lasting ∼2 min, some major outlets showed persistent activity over the scale of days and even months. This persistence was surprising given the previously observed ephemerality of spatial structure at the field scale. This persistence suggests that, at the centimeter scale, conduits are reopened as a result of a drop in tensile strength due to deformation of sediments by the rising bubbles. The mechanistic insight from this work sheds light on the spatiotemporal distribution of methane venting from organic‐rich sediments and has important implications for bubble survival in the water column and associated biogeochemical pathways of methane.
Statistical investigation of Na layer response to geomagnetic activity using resonance scattering measurements by Odin/OSIRIS
Authors: Tsuda T. T. , Nakamura T. , Ejiri M. K. , Nishiyama T. , Hosokawa K. , Takahashi T. , Gumbel J. , Hedin J. 
Published: April 2017

AbstractWe have performed a statistical investigation of the global response of the Na layer to geomagnetic activity using Na density data from 2004 to 2010 obtained using the Optical Spectrograph and Infrared Imager System (OSIRIS) on board the Odin satellite. In the analysis, we categorized the Na density data according to the auroral electrojet (AE) index and then compared the resulting data sets. Regarding the results, we found a significant decrease in the Na density above a height of ∼95 km in both the southern and northern polar regions with an increase in the AE index. The cause of the decrease in the Na density is discussed, and we conclude that the decrease in the Na density was mainly due to the effect of energetic particle precipitation.
Constraining the mass balance of East Antarctica
Authors: Martin‐Español Alba , Bamber Jonathan L. , Zammit‐Mangion Andrew 
Published: April 2017

AbstractWe investigate the mass balance of East Antarctica for the period 2003–2013 using a Bayesian statistical framework. We combine satellite altimetry, gravimetry, and GPS with prior assumptions characterizing the underlying geophysical processes. We run three experiments based on two different assumptions to study possible solutions to the mass balance. We solve for trends in surface mass balance, ice dynamics, and glacial isostatic adjustment. The first assumption assigns low probability to ice dynamic mass loss in regions of slow flow, giving a mean dynamic trend of 17 ± 10 Gt yr−1 and a total mass imbalance of 57 ± 20 Gt yr−1. The second assumption considers a long‐term dynamic thickening hypothesis and an a priori solution for surface mass balance from a regional climate model. The latter results in estimates 3 to 5 times larger for the ice dynamic trends but similar total mass imbalance. In both cases, gains in East Antarctica are smaller than losses in West Antarctica.
Calibrating the amplitude source location (ASL) method by using active seismic sources: An example from Te Maari volcano, Tongariro National Park, New Zealand
Authors: Walsh B. , Jolly A. D. , Procter J. 
Published: April 2017

AbstractA frequently applied amplitude source location (ASL) method is here calibrated and optimized by using active seismic sources located at the surface of a dry stream channel. The ASL produced location discrepancies larger than 1.0 km laterally and 500 m in depth by using independently determined velocity model, attenuation, and site amplification factors (AFs). Sensitivity tests for ASL input parameters show that attenuation and velocity have moderate influence on the location but are easy to independently constrain. AFs are shown to strongly influence the location, and their application may introduce substantial location uncertainties. Model uncertainties are accommodated with either lateral or depth changes depending on the input parameters, station corrections, and the source‐station geometry.