bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perception of first respiratory infection withPseudomonas aeruginosaby people with cystic fibrosis and those close to them: an online qualitative study
Authors: Palser Sally C , Rayner Oliver C , Leighton Paul A , Smyth Alan R 
Published: December 2016

BackgroundPeople with cystic fibrosis (CF) are susceptible to respiratory infection withPseudomonas aeruginosa(PA), which may become chronic if initial eradication fails. Environmental acquisition and person-to-person transmission can occur. Respiratory PA infection is associated with increased mortality and more hospitalisations. This may cause patients and families anxiety and lead them to adopt preventive measures which may be ineffectual and intrusive. It is not possible to hold a conventional focus group to explore these issues because people with CF cannot meet together due to the risk of cross-infection.ObjectiveTo explore the perceptions of first respiratory infection with PA in people with CF and those close to them.DesignWe designed an online survey, to maximise accessibility and avoid the risk of cross-infection. This established the respondent's relationship with CF, asked 3 open questions about perceptions of PA and a final question about the prioritisation of research. Responses were analysed using a structured, iterative process. We identified keywords, analysed these incontext and derived key themes.SettingPromotion through social media allowed respondents from any country to participate.ParticipantsPeople with CF and those close to them.ResultsResponses were received from 393 people, including 266 parents and 97 people with CF. The key themes were the emotional burden of PA (fear in particular); the burden of treatment PA entails and the need for accurate knowledge about PA.ConclusionsLack of knowledge and the health beliefs of individuals may promote fear of infection and inappropriate avoidance measures. Uncertainty about the implications of PA infection and the treatment required may cause anxiety. Healthcare professionals should provide clear information about how PA might be acquired and the treatment necessary, making clear the limitations of current understanding and acknowledging health beliefs.
Model-based cost-effectiveness analysis of B-type natriuretic peptide-guided care in patients with heart failure
Authors: Mohiuddin Syed , Reeves Barnaby , Pufulete Maria , Maishman Rachel , Dayer Mark , Macleod John , McDonagh Theresa , Purdy Sarah , Rogers Chris , Hollingworth William 
Published: December 2016

ObjectiveMonitoring B-type natriuretic peptide (BNP) to guide pharmacotherapy might improve survival in patients with heart failure with reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF). However, the cost-effectiveness of BNP-guided care is uncertain and guidelines do not uniformly recommend it. We assessed the cost-effectiveness of BNP-guided care in patient subgroups defined by age and ejection fraction.MethodsWe used a Markov model with a 3-month cycle length to estimate the lifetime health service costs, quality-adjusted life years (QALYs) and incremental net monetary benefits (iNMBs) of BNP-guided versus clinically guided care in 3 patient subgroups: (1) HFrEF patients <75 years; (2) HFpEF patients <75 years; and (3) HFrEF patients ≥75 years. There is no evidence of benefit in patients with HFpEF aged ≥75 years. We used individual patient data meta-analyses and linked primary care, hospital and mortality data to inform the key model parameters. We performed probabilistic analysis to assess the uncertainty in model results.ResultsIn younger patients (<75 years) with HFrEF, the mean QALYs (5.57 vs 5.02) and costs (£63 527 vs £58 139) were higher with BNP-guided care. At the willingness-to-pay threshold of £20 000 per QALY, the positive iNMB (£5424 (95% CI £987 to £9469)) indicates that BNP-guided care is cost-effective in this subgroup. The evidence of cost-effectiveness of BNP-guided care is less strong for younger patients with HFpEF (£3155 (−£10 307 to £11 613)) and older patients (≥75 years) with HFrEF (£2267 (−£1524 to £6074)). BNP-guided care remained cost-effective in the sensitivity analyses, albeit the results were sensitive to assumptions on its sustained effect.ConclusionsWe found strong evidence that BNP-guided care is a cost-effective alternative to clinically guided care in younger patients with HFrEF. It is potentially cost-effective in younger patients with HFpEF and older patients with HFrEF, but more evidence is required, particularly with respect to the frequency, duration and BNP target for monitoring. Cost-effectiveness results from trials in specialist settings cannot be generalised to primary care.
Inflammatory lung disease a potential risk factor for onset of idiopathic inflammatory myopathies: results from a pilot study
Authors: Helmers Sevim Barbasso , Jiang Xia , Pettersson David , Wikman Anna-Lis , Axelman Pia , Lundberg Åsa , Lundberg Ingrid E , Alfredsson Lars 
Published: December 2016

ObjectivesTo assess the association between inflammatory lung disease and the risk of developing idiopathic inflammatory myopathies.MethodsA population-based case–control study was conducted. Adult myositis cases, identified from the Swedish inpatient registry (diagnosed between 1995 and 1997), and randomly selected controls matched to cases on the date of birth, gender and residency, were asked to fill out a questionnaire with questions on lifestyle, environmental exposures and health. Eventually, 100 cases and 402 controls responded to the questionnaire and were included in the analyses. Exposure was defined as self-reported preceding inflammatory lung diseases (pneumonia, tuberculosis or sarcoidosis). The association between the exposure and risk of developing myositis was evaluated by calculating OR together with 95% CIs in logistic regressions.Results42 (42%) cases and 112 (28%) controls reported preceding inflammatory lung disease. Median duration between inflammatory lung disease and first symptom of myositis was 30 years. We observed a significant association between self-reported history of lung disease at study inclusion and diagnosis of myositis (crude OR=1.8 (1.1 to 2.9); smoking adjusted OR=1.9 (1.2 to 3.1)). We further identified a modestly increased, yet non-significant, association between preceding inflammatory lung disease (prior to index year) and diagnosis of myositis (smoking adjusted OR=1.6 (0.9 to 2.8)). The association was more pronounced among the cases of myositis with concurrent interstitial lung disease (OR=3.8 (1.0 to 14.5)).ConclusionsPatients with preceding inflammatory lung disease tend to have an increased risk of developing myositis compared to those without. The effect was more pronounced among patients with myositis with concurrent interstitial lung disease. Thus inflammatory lung disease may constitute a risk factor for myositis.
The DART Study: Results from the Dose-Escalation and Expansion Cohorts Evaluating the Combination of Dalantercept plus Axitinib in Advanced Renal Cell Carcinoma
Authors: Voss Martin H. , Bhatt Rupal S. , Plimack Elizabeth R. , Rini Brian I. , Alter Robert S. , Beck J. Thaddeus , Wilson Dawn , Zhang Xiaosha , Mutyaba Musa , Glasser Chad , Attie Kenneth M. , Sherman Matthew L. , Pandya Shuchi S. , Atkins Michael B. 
Published: December 2016

Abstract
Purpose: Activin receptor-like kinase 1 (ALK1) is a novel target in angiogenesis. Concurrent targeting of ALK1 and VEGF signaling results in augmented inhibition of tumor growth in renal cell carcinoma (RCC) xenograft models. Dalantercept is an ALK1-receptor fusion protein that acts as a ligand trap for bone morphogenetic proteins 9 and 10. The DART Study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of dalantercept plus axitinib in patients with advanced RCC and determined the optimal dose for further testing.
Experimental Design: Patients received dalantercept 0.6, 0.9, or 1.2 mg/kg subcutaneously every 3 weeks plus axitinib 5 mg by mouth twice daily until disease progression or intolerance.
Results: Twenty-nine patients were enrolled in the dose escalation (n = 15) and expansion (n = 14) cohorts. There were no dose-limiting toxicities or grade 4/5 treatment-related adverse events. In addition to common VEGFR tyrosine kinase inhibitor effects, such as fatigue and diarrhea, commonly seen treatment-related adverse events were peripheral edema, epistaxis, pericardial effusion, and telangiectasia. The objective response rate by RECIST v1.1 was 25% with responses seen at all dose levels. The overall median progression-free survival was 8.3 months.
Conclusions: The combination of dalantercept plus axitinib is well tolerated and associated with clinical activity. On the basis of safety and efficacy results, the 0.9 mg/kg dose level was chosen for further study in a randomized phase II trial of dalantercept plus axitinib versus placebo plus axitinib. Clin Cancer Res; 23(14); 3557–65. ©2016 AACR.
Predictive Outcomes for HER2-enriched Cancer Using Growth and Metastasis Signatures Driven By SPARC
Authors: Güttlein Leandro N. , Benedetti Lorena G. , Fresno Cristóbal , Spallanzani Raúl G. , Mansilla Sabrina F. , Rotondaro Cecilia , Raffo Iraolagoitia Ximena L. , Salvatierra Edgardo , Bravo Alicia I. , Fernández Elmer A. , Gottifredi Vanesa , Zwirner Norberto W. , Llera Andrea S. , Podhajcer Osvaldo L. 
Published: December 2016

Abstract
Understanding the mechanism of metastatic dissemination is crucial for the rational design of novel therapeutics. The secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein which has been extensively associated with human breast cancer aggressiveness although the underlying mechanisms are still unclear. Here, shRNA-mediated SPARC knockdown greatly reduced primary tumor growth and completely abolished lung colonization of murine 4T1 and LM3 breast malignant cells implanted in syngeneic BALB/c mice. A comprehensive study including global transcriptomic analysis followed by biological validations confirmed that SPARC induces primary tumor growth by enhancing cell cycle and by promoting a COX-2–mediated expansion of myeloid-derived suppressor cells (MDSC). The role of SPARC in metastasis involved a COX-2–independent enhancement of cell disengagement from the primary tumor and adherence to the lungs that fostered metastasis implantation. Interestingly, SPARC-driven gene expression signatures obtained from these murine models predicted the clinical outcome of patients with HER2-enriched breast cancer subtypes. In total, the results reveal that SPARC and its downstream effectors are attractive targets for antimetastatic therapies in breast cancer.
Implications: These findings shed light on the prometastatic role of SPARC, a key protein expressed by breast cancer cells and surrounding stroma, with important consequences for disease outcome. Mol Cancer Res; 15(3); 304–16. ©2016 AACR.
Framing the Holocaust in popular knowledge: 3 articles about the Holocaust in English, Hebrew and Polish Wikipedia
Authors: Wolniewicz-Slomka Daniel 
Published: December 2016

Framing the Holocaust in popular knowledge: 3 articles about the Holocaust in English, Hebrew and Polish WikipediaThe goal of this article is to examine how different events and phenomena related to the Second World War and the Holocaust are framed via Wikipedia articles written in Polish, Hebrew and English. Departing from the pillars of the theory of framing in mass media, the article conducts a content analysis of three articles, in three different languages. The articles under analysis are the following: “Auschwitz-Birkenau Camp”, “The Pogrom in Jedwabne”, and “Righteous Among the Nations”. The analysis will use the four roles of frames as categories, determined by Entman: definition of the problem/phenomenon, causal interpretation, moral evaluation, and treatment recommendation. Analyzing how the articles fulfill each of the roles in the different languages, the research hypothesis is that the framing of the phenomena will differ between the versions, and each version will follow pillars of the collective memory of the Holocaust in its respective country. Findings, however, are not in complete compliance with this hypothesis. Kształtowanie popularnej wiedzy o Holocauście na przykładzie trzech artykułów z polskiej, hebrajskiej i angielskiej WikipediiCelem artykułu jest zbadanie, jak przedstawiane są wybrane wydarzenia i zjawiska, związane z historią II wojny światowej oraz Holokaustem, w internetowej encyklopedii „Wikipedia” w różnych językach. Prezentowana analiza treści opiera się na teorii framingu w mass mediach i obejmuje trzy artykuły: „Auschwitz-Birkenau”, „Pogrom w Jedwabnem” oraz „Sprawiedliwy wśród Narodów Świata”, opublikowane w językach polskim, angielskim oraz hebrajskim. W analizie wykorzystano cztery role „ram” (frames), sformułowane przez Entmana: definicja problemu/zjawiska, interpretacja przyczyn, ewaluacja moralna oraz propozycja rozwiązań. Autor, badając to, jak poszczególne artykuły wypełniają każdą z tych ról, stawia hipotezę, zgodnie z którą teksty przedstawiają ten sam temat w różny sposób, w zależności od podstaw pamięci zbiorowej w danym kraju. Wyniki badań jednak nie zawsze są zgodne z tą hipotezą.
The Historical Lexicon of Nationalism: Ethnicity, Ethnos, Race, Volksstamm: Historical Footnotes
Authors: Franzinetti Guido 
Published: December 2016

The Historical Lexicon of Nationalism: Ethnicity, Ethnos, Race, Volksstamm: Historical FootnotesThis paper is primarily concerned with the etymology of some terms in the historical lexicon of nationalism: ethnicity, ethnos, race, Volksstamm. It is argued that European and US usages of race are radically different. It is also argued that the Habsburg-era term Volksstamm was the basis for the term narodnost in Socialist Yugoslavia. Historyczny słownik nacjonalizmu: etniczność, ethnos, rasa, Volksstamm: Przypisy historyczneW moim artykule koncentruję się przede wszystkim na etymologii wybranych terminów w historycznym leksykonie nacjonalizmu: etniczność, ethnos, rasa, Volksstamm. Argumentuję, że europejskie użycia terminu „rasa” całkowicie różnią się od amerykańskich. Staram się unaocznić, że używany w czasach imperium Habsburgów termin Volksstamm stał się podstawą dla terminu narodnost w socjalistycznej Jugosławii.
The History of the Normative Opposition of “Language versus Dialect”: From Its Graeco-Latin Origin to Central Europe’s Ethnolinguistic Nation-States
Authors: Kamusella Tomasz 
Published: December 2016

The History of the Normative Opposition of “Language versus Dialect”: From Its Graeco-Latin Origin to Central Europe’s Ethnolinguistic Nation-StatesThe concept of “a language” (Einzelsprache, that is, one of many extant languages) and its opposition to “dialect” (considered as a “non-language,” and thus subjugable to an already recognized language merely as “its” dialect) is the way people tend to think about languages in the West today. It appears to be a value-free, self-evident conception of the linguistic position. So much so that the concept of “language” was included neither in Immanuel Kant’s system of categories, nor in the authoritative Geschichtliche Grundbegriffe: Historisches Lexikon zur politisch sozialen Sprache in Deutschland. This paper sketches the rise of the “dialect vs language” opposition in classical Greek, its transposition onto classical Latin, and its transfer, through medieval and renaissance Latin, to the early modern period. On the way, the Greek and Latin terms for “language” (and also for “dialect”) sometimes functioned as synonyms for peoples (that is, ethnic groups), which – importantly – contributed to the rise of the normative equation of language with nation in the early nineteenth century. It was the beginning of the ethnolinguistic kind of nationalism that prevails to this day in Central Europe. Dzieje normatywnej dychotomii języka i dialektu: Od greko-łacińskich źródeł po państwa etnicznojęzykowe Europy ŚrodkowejPojęcie języka jako jednego z wielu (Einzelsprache) stawiane w diametralnej opozycji do „dialektu” (czyli „nie-języka”, który normatywnie musi zostać przyporządkowany jakiemuś już wcześniej uznanemu językowi jako jeden z jego dialektów) stanowi formę pojęciową, poprzez pryzmat której postrzega się języki i dyskutuje o nich we współczesnym świecie Zachodu. Z powodu powszechnego uznania owa forma pojęciowa wydaje się tak oczywista i wolna od nacechowania ideologicznego, że Immanuel Kant nie uwzględnił języka w zaproponowanym przez siebie systemie kategorii filozoficznych, podobnie jak i autorzy niezmiernie wpływowego dzieła z zakresu historiografii i socjologii politycznej o znamiennym tytule Geschichtliche Grundbegriffe: Historisches Lexikon zur politisch sozialen Sprache in Deutschland. W niniejszym artykule przedstawiam wyłonienie się opozycji języka wobec dialektu w starożytnej grece oraz jego recepcję na gruncie łaciny od starożytności rzymskiej po okres nowożytny. W ciągu wieków utarło się używanie greckich i łacińskich terminów w odniesieniu do „języka” jako synonimów na określenie ludów (czy też grup etnicznych), co we wczesnym XIX stuleciu silnie wpłynęło na wykształcenie się normatywnego zrównania języka z narodem. Stanowiło to początek fenomenu znanego pod nazwą „nacjonalizmu etnicznojęzykowego”, który na poziomie państw dominuje po dziś dzień w całej Europie Środkowej.
The Theme of the Fountain-Wound in a Baroque Manuscript Meditation: The Impact of Iconography on Poetry
Authors: Panasiuk Joanna 
Published: December 2016

The Theme of the Fountain-Wound in a Baroque Manuscript Meditation: The Impact of Iconography on PoetryBehind the foundation of the monastic meditation about fountains is a concrete devotional graphic from Western Europe. It is the Dutch emblem that is the key to the interpretation of the religious text, which uses words to directly refer to a specific image. These cultural correspondences constitute a curious phenomenon. They present the spirituality as well as the mentality of seventeenth- and eighteenth-century European society. This seems to confirm, at the same time, the fact that no artistic activity is ever isolated. Motyw fontanny-ran w barokowej rękopiśmiennej medytacji: wpływ ikonografii na poezjęU początków monastycznej medytacji o fontannie stoi konkretna dewocyjna grafika z Zachodu Europy. To holenderski emblemat, będący kluczem do interpretacji tekstu religijnego, posługującego się słowami w celu bezpośredniego odwołania do owego obrazu. Te kulturowe korespondencje stanowią ciekawe zjawisko. Odsłaniają duchowość i mentalność siedemnasto- i osiemnastowiecznego społeczeństwa europejskiego. Równocześnie zdają się potwierdzać fakt, iż żadna aktywność artystyczna nigdy nie jest izolowana.
A Transаesthetic Interpretation of "Pamięć nareszcie" / "Memory at Last" by Wisława Szymborska
Authors: Kulavkova Katica 
Published: December 2016

A Transаesthetic Interpretation of Pamięć nareszcie / Memory at Last by Wisława SzymborskaThis essay attempts to combine several elements relevant for such interpretative practices as hermeneutics, textual explication, speech acts theory, C. G. Jung’s analytical psychology, as well inspirations taken from ritual studies, archetypal literary criticism, and transcendental hermeneutics. This combination of interpretational practices shall be applied to the reading and analysis of Wisława Szymborska’s poem Pamięć nareszcie / Memory at Last. My chief aim is to analyse the ritual dimension of the poem (without disregarding, however, the work’s stylistic features). Wiersz Pamięć nareszcie Wisławy Szymborskiej. Interpretacja transestetycznaNiniejszy esej jest próbą połączenia kilku elementów pełniących ważną rolę w takich praktykach interpretacyjnych jak hermeneutyka, eksplikacja tekstu, teoria aktów mowy, psychologia analityczna C. G. Junga, a także inspiracji płynących z badań nad rytuałem i archetypami, wreszcie z hermeneutyki transcendentnej. Połączenie wymienionych praktyk interpretacji będzie służyło lekturze i analizie wiersza Wisławy Szymborskiej Pamięć nareszcie. Moim głównym celem jest analiza rytualnego wymiaru wiersza (choć także jego cech stylistycznych).
Neural correlates of fears of abandonment and rejection in borderline personality disorder
Authors: Romaniuk Liana , Pope Merrick , Nicol Katie , Steele Douglas , Hall Jeremy 
Published: December 2016

Background: Borderline personality disorder (BPD) is a prevalent and disabling psychiatric condition commonly associated with early life adversity. Social difficulties are a prominent symptom of BPD, particularly a fear of abandonment and rejection. There has recently been a growing interest in the neural basis of these social symptoms and their relationship to early experience. Methods: In the current study, we examined social brain function and learning in BPD using functional MRI. Participants with BPD (n=20) and healthy controls (n=16) completed a computerized parametric social exclusion task (the “Cyberball” task). Brain activation was compared between groups and related to social symptom status and experiences of childhood trauma. Additional analyses were conducted using a reinforcement learning model treating social inclusion as a rewarding event. Results: Participants with BPD demonstrated a group effect of decreased right temporoparietal junction (TPJ) activation (p < 0.013, FWE-corrected). Increased fear of abandonment in BPD was associated with reduced inclusion-related activation of the inferior frontal gyrus (p = 0.003, FWE-corrected). Across all participants, TPJ inclusion-related activation was modified by prior experience of childhood physical neglect (p < 0.001, FWE-corrected). Reinforcement learning modelling revealed decreased midbrain responses to social inclusion in BPD participants (p = 0.028, FWE-corrected within midbrain mask), with decreased anticipatory midbrain activation in anticipation of social inclusion specifically associated with fears of abandonment (p = 0.019, FWE-corrected within a midbrain mask). Conclusions: The findings demonstrate alterations in social brain function and social reinforcement learning in BPD, which are influenced by both early life experience and symptom status.
Ideological Purity vs. Hybridization Trade-Off: When Do Islamic Banks Hire Managers from Conventional Banking?
Authors: Boone Christophe , Özcan Serden 
Published: December 2016

Organizations that compete in institutional environments in which oppositional logics compete for dominance face a risk-return trade-off between maintaining ideological purity versus pragmatism by borrowing template elements from the rival ideology. Deviating from ideological purity might improve a firm’s competitive strength, however, at the same time, it might also undermine its very identity and legitimacy. Although such decisions are of strategic importance, research about why, how, and where these trade-offs are made is still limited. We develop the argument that organizations will be more likely to deviate from ideological purity when the potential return of borrowing from the oppositional template exceeds the perceived risk of doing so. The more organizations aspire to be ideologically pure, the more they are constrained by the moral codes that define the category, and, therefore, the higher the risk associated with deviating from purity. However, given the potential benefits of pragmatism, pure organizations will be particularly sensitive to contextual cues that reduce the perceived risk of borrowing, tilting their trade-off balance toward pragmatism. Specifically, we expect that pure (compared to less pure) organizations will be particularly tempted to seize the opportunities offered by pragmatism when (1) they perform below aspiration, (2) the relevant market attaches less importance to ideological purity, and (3) pragmatism is becoming taken-for-granted. We test our hypotheses on detailed data of the hiring process of branch managers of Turkish Islamic banks analyzing when and in which communities Islamic banks hire managers from conventional banking in order to implement their geographical expansion strategy in the period 2003–2016.