bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Rubber Content on Performance of Ultra-High-Performance Rubberised Concrete (UHPRuC)
Authors: Pham Thong M. , Lee Josh , Pournasiri Emad , Li Jun , Peng Zhen , Bi Kaiming , Tran Tung M. 
Published: September 2024

AbstractThis study investigated the effect of rubber content on the mechanical characteristics of ultra-high-performance rubberised concrete (UHPRuC). The results revealed a distinctive non-linear decrease in the dry density of UHPRuC as the rubber content increased. Notably, lower rubber content led to a columnar failure mode, while higher content (≥ 20%) exhibited a mixed failure mode with vertical cracking and diagonal fracture. Importantly, the compressive strength showed minimal reduction compared to conventional concrete, presenting a remarkable 50% mitigation of strength reduction compared to previous studies. Utilising reference concrete with robust bond strength proved highly effective in preserving strength in rubberized concrete. Despite its effectiveness in mitigating compressive strength reduction, UHPC could not effectively offset flexural strength loss, which ranged from 1.5 to 3 times that of compressive strength loss. The addition of rubber aggregate in UHPC reduced the peak flexural strength, residual strength, and flexural toughness at a similar rate, while significantly increasing the vibration decaying rate. Incorporating 40% rubber in UHPRuC reduced the eCO2 up to 37%. Our findings emphasise the importance of reference concrete with good bond strength and shows that the addition of rubber aggregate in UHPC leads to reductions in strength but increases the energy-dissipating capacity.
Dietary processed former foodstuffs for broilers: impacts on growth performance, digestibility, hematobiochemical profiles and liver gene abundance
Authors: Srikanthithasan Karthika , Gariglio Marta , Diaz Vicuna Elena , Fiorilla Edoardo , Miniscalco Barbara , Zambotto Valeria , Cappone Eleonora Erika , Stoppani Nadia , Soglia Dominga , Raspa Federica , Nery Joana , Giorgino Andrea , Sala Roser , Martínez Marínz Andrés Luis , Madrid Sanchez Josefa , Schiavone Achille , Forte Claudio 
Published: September 2024

Abstract
Background
The present experiment aimed to evaluate the effects of commercially processed former foodstuffs (cFF) as dietary substitutes of corn, soybean meal and soybean oil on the growth performance, apparent total tract digestibility (ATTD), hematobiochemical profiles, and liver gene abundance in broiler chickens. Two hundred one-day-old male ROSS-308 chicks were assigned to 4 dietary groups (5 replicates of ten birds per replicate) according to their average body weight (BW, 38.0 ± 0.11 g). All groups received a two-phase feeding program: starter, d 1–12 and grower, d 12–33. The control group (cFF0) was fed a standard commercial feed based on corn, soybean meal and soybean oil. The other three groups received diets in which the feed based on corn, soybean meal, and soybean oil was partially replaced with cFF at a substitution level of 6.25% (cFF6.25), 12.5% (cFF12.5) or 25% (cFF25) for the following 33 d.

Results
The growth performance data showed no differences in BW or average daily gain among groups, although the average daily feed intake decreased during the grower period (12–33 d) and over entire experimental period (1–33 d) in a linear manner as the cFF inclusion level rose (P = 0.026), positively affecting the gain to feed ratio (P = 0.001). The ATTD of dry matter of the cFF-fed groups were greater with respect to control group and increased throughout the experimental period, whereas the ATTD of ether extract linearly decreased with increasing levels of cFF-fed groups compared with control group and throughout the experimental period (P < 0.05). Additionally, a linear increase in the heterophil to lymphocyte ratio, serum cholesterol, triglycerides and alanine-aminotransferase were observed with increasing dietary levels of cFF (P < 0.05); however, no differences were observed in lipoprotein lipase or sterol regulatory element binding transcription factor gene abundance.

Conclusions
The results of this experiment demonstrate that it is possible to incorporate cFF into nutritionally balanced diets for broiler chickens, even up to 25% substitution levels, for up to 33 d without adversely impacting the overall growth performance of male broiler chickens raised under commercial conditions. Further studies are essential to validate the hematological trait findings.
Implementing healthy food policies in health sector settings: New Zealand stakeholder perspectives
Authors: Rosin Magda , Ni Mhurchu Cliona , Mackay Sally 
Published: September 2024

Abstract
Background
In 2016, a voluntary National Healthy Food and Drink Policy was released to improve the healthiness of food and drinks for sale in New Zealand health sector organisations. The Policy aims to role model healthy eating and demonstrate commitment to health and well-being of hospital staff and visitors and the general public. This study aimed to understand the experiences of hospital food providers and public health dietitians/staff in implementing the Policy, and identify tools and resources needed to assist with the implementation.

Methods
A maximum variation purposive sampling strategy (based on a health district’s population size and food outlet type) was used to recruit participants by email. Video conference or email semi-structured interviews included 15 open-ended questions that focused on awareness, understanding of, and attitudes towards the Policy; level of support received; perceived customer response; tools and resources needed to support implementation; and unintended or unforeseen consequences. Data was analysed using a reflexive thematic analysis approach.

Results
Twelve participants (eight food providers and four public health dietitians/staff) were interviewed; three from small (< 100,000 people), four from medium (100,000-300,000 people) and five from large (> 300,000 people) health districts. There was agreement that hospitals should role model healthy eating for the wider community. Three themes were identified relating to the implementation of the Policy: (1) Complexities of operating food outlets under a healthy food and drink policy in public health sector settings; (2) Adoption, implementation, and monitoring of the Policy as a series of incoherent ad-hoc actions; and (3) Policy is (currently) not achieving the desired impact. Concerns about increased food waste, loss of profits and an uneven playing field between food providers were related to the voluntary nature of the unsupported Policy. Three tools could enable implementation: a digital monitoring tool, a web-based database of compliant products, and customer communication materials.

Conclusions
Adopting a single, mandatory Policy, provision of funding for implementation actions and supportive tools, and good communication with customers could facilitate implementation. Despite the relatively small sample size and views from only two stakeholder groups, strategies identified are relevant to policy makers, healthcare providers and public health professionals.
Comparative clinical study of Mist Amen Fevermix and Edhec Malacure: two polyherbal products used for the treatment of uncomplicated malaria in Ghana against Artemether/Lumefantrine
Authors: Turkson Bernard K. , Amponsah Isaac K. , Agyemang Alfred Ofori , Mensah Merlin L. K. , Nketia Reinhard I. , Nkrumah Desmond , Baidoo Michael F. , Mensah Abraham Y. , Achaab Emmanuel , Accam Burnett Tetteh 
Published: September 2024

AbstractThe use of herbal products for the treatment of malaria, has increased globally. However, inadequate scientific studies about the safety and effectiveness of such herbal products have been raised. Also, the reduced sensitivity of the malaria parasites to artemisinin-based combination therapies is of concern. There is therefore the need for new antimalarial medications including those from alternative sources such as herbal medicinal products. In this study, a prospective, comparative parallel group randomized, clinical study was done to assess the safety and effectiveness of Mist Amen Fevermix and Mist Edhec Malacure with Artemether/Lumefantrine as control at the Tafo Government Hospital, Kumasi between July and November 2019, after Committee on Human Research, Publication and Ethics approval (CHRPE/AP/424/19). The study was conducted in accordance with Good Clinical and Laboratory Practice (GCLP) and registered with the Pan African Clinical Trials Registry with trial number PACTR202109664146698. Participant completed an informed consent form. Randomization was based on a single sequence to allocate participants to a group. SPSS version 19. One-way ANOVA test and exploratory statistics was used for data analysis. Total sample size was 150 participants with 50 on each arm of the group. Male and female patients aged 15–45 years and meet inclusion criteria with clinically established malaria were treated with Mist Amen Fevermix and Mist Edhec Malacure, at the specified doses of 45 mls (0.1063 g) and 30 mls (0.0521 g) three times daily after meals for three days. Artemether/Lumefantrine was administered at a dose of 80/480 mg/kg twice daily after meals for three days. Baseline data was taken on day 0. Patients were then followed up on Day 3, 7 and 28 to establish treatment outcomes and any side effect using a checklist for signs and symptoms and Karnofsky’s scale to assess the quality of life. Mist Amen Fevermix was effective with a cure rate of 95.89%. Mist Edhec Malacure was also effective with a cure rate of 91.87%. The cure rate of Artemether/Lumefantrine was 97.25%. Kidney and liver panels were within normal reference range at the end of the 28-day study. This study supports the use of Mist Amen Fevermix and Mist Edhec Malacure, two multi-component products as safe and effective for the treatment of uncomplicated malaria. Both products achieved a comparable clinical treatment outcome with Artemether/Lumefantrine.
Simple techniques to bypass GenAI text detectors: implications for inclusive education
Authors: Perkins Mike , Roe Jasper , Vu Binh H. , Postma Darius , Hickerson Don , McGaughran James , Khuat Huy Q. 
Published: September 2024

AbstractThis study investigates the efficacy of six major Generative AI (GenAI) text detectors when confronted with machine-generated content modified to evade detection (n = 805). We compare these detectors to assess their reliability in identifying AI-generated text in educational settings, where they are increasingly used to address academic integrity concerns. Results show significant reductions in detector accuracy (17.4%) when faced with simple techniques to manipulate the AI generated content. The varying performances of GenAI tools and detectors indicate they cannot currently be recommended for determining academic integrity violations due to accuracy limitations and the potential for false accusation which undermines inclusive and fair assessment practices. However, these tools may support learning and academic integrity when used non-punitively. This study aims to guide educators and institutions in the critical implementation of AI text detectors in higher education, highlighting the importance of exploring alternatives to maintain inclusivity in the face of emerging technologies.
[18F]AlF-PSMA-11 PET in diagnosing prostate cancer: a head-to-head comparison with [68Ga]Ga-PSMA-11 PET and an exploration of dual-phase scanning
Authors: Li Xiao , Yu Mingming , Yang Jian , Li Danni , Li Rou , Mao Juanli , Zuo Changjing , Liang Zeying , Li Qiang , Cheng Chao 
Published: September 2024

Abstract
Purpose
To evaluate the physiological distribution and tumour detection ability of [18F]AlF-PSMA-11 positron emission tomography (PET) dual-phase scans in patients with prostate cancer (PCa).

Methods
As a retrospective study, clinical and PET data of PCa patients who underwent dual-phase [18F]AlF-PSMA-11 PET of routine scan (45–50 min) and delayed scan (120 min) from November 2020 to June 2021 were collected, and physiological and pathological regions of interest were quantified to determine the time-dependent maximum standardized uptake value (SUVmax) of [18F]AlF-PSMA-11. Part of the above subjects who underwent [68Ga]Ga-PSMA-11 PET in the following 6 months were included in a head-to-head comparison. The difference with a p-value < 0.05 was defined as statistical significance. Diagnosis accuracy of primary and metastatic lesions was measured referring to the surgical findings, pathology, and follow-up imaging.

Results
[68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 were of the comparable uptake in glands in head, but the latter was of a significant lower distribution in liver and spleen. For the 25 patients initially diagnosed with prostate cancer and 3 patients with biochemical recurrence after radical surgery, the SUVmax of the primary lesions, lacrimal glands, parotid glands and submandibular glands was higher at 120 min compared to that at 45–50 min, but not a significant difference. SUVmax of the liver, spleen and bladder decreased significantly at 120 min, but the bladder SUVmax remained higher than that of primary lesions. SUVmax of the kidneys and centrum was the same in dual-phase scans. For the 31 primary lesions detected in [18F]AlF-PSMA-11 PET, both the SUVmax of the two phases kept the positive correlation with PSA, Gleason score and initial risk stratification. For the 39 distant metastatic lesions, 94.87% accuracy of routine scan and 100% accuracy of delayed scan were acquired, and 7.14% patients (2/28) benefited from the dual-phase [18F]AlF-PSMA-11 scans that revealed novel information on metastatic lesions compared to the routine scan.

Conclusion
[18F]AlF-PSMA-11 PET expanded the time window and further decreased metabolic background of [68Ga]Ga-PSMA-11 PET. The dual-phase scan of [18F]AlF-PSMA-11 PET can benefit prostate cancer diagnosis via providing more PSMA-specific information.
The coming of age of digital technologies in global health within the Indian context: a review
Authors: Dileep Vivek N. 
Published: September 2024

AbstractDigital approaches have been recognized as an essential instrument for improving health systems to fulfill the Sustainable Development Goals (SDGs) and the targets for universal health care. This review article discusses policy and regulatory developments in the arena of digital health, at the global level, with a particular focus on India. It also points out that there is a need for convergence among industry, policymakers, and civil society in addressing issues of privacy and accessibility to all individuals who require affordable and quality healthcare. For the best use of digital services, inter-sectoral collaboration is necessary to integrate organizational, human, financial, and technological resources.
Review of physiological compounds and health benefits of soybean paste (doenjang): exploring its bioactive components
Authors: Park Young Kyoung , Kim Jinwon , Ryu Myeong Seon , Jeong Do-Youn , Yang Hee-Jong 
Published: September 2024

AbstractThis review paper explores the history, cultural significance, and functional characteristics of soybean paste (doenjang) in Korean cuisine. In particular, it covers its origins, cultural importance, production methods, functionalities, and associated risks. This review delves into the nutritional and functional aspects of fermented soybean products, focusing on compounds in soybean paste linked to health benefits, such as anticancer, anti-obesity, anti-diabetic, and antithrombotic properties. The key bioactive compounds identified in soybean paste include total phenols, total flavonoids, γ-Aminobutyric acid, vitamin B group, and vitamin E. These compounds are primarily produced through microbial fermentation, which enhances their biological activity. Additionally, the review addresses potential risks such as biogenic amines, aflatoxins, Bacillus cereus contamination, and high sodium levels, and suggests methods for mitigating these risks. By synthesizing current research, this paper aims to provide a comprehensive understanding of the physiological compounds in soybean paste and their health benefits. It also highlights the need for strategies to reduce associated risks.
Towards a definition of food processing: conceptualization and relevant parameters
Authors: Ristic Dusan , Bender Denisse , Jaeger Henry , Heinz Volker , Smetana Sergiy 
Published: September 2024

AbstractThere are several classifications of foods that also include the level of their processing, with NOVA classification appearing to be the most adopted. However scientific consensus is still missing on how to define, characterize and classify food processing. The classifications are typically based on the health impacts of foods and do not fully include the engineering perspective of processing, i.e., the application of physical, chemical, or biotechnological unit operations during food manufacturing, and the composition of a food product.This review offers an engineering perspective and definition of food processing, based on the change of mass and energy, allowing distinguishment of the impacts caused by food processing during the biomass transformation to food products. The improved understanding of the causes of undesired changes in food properties could be used for nutritional public policy recommendations and would contribute to combating some of the chronic diseases related to food consumption patterns.Proposed is the definition of “Food processing” as a sum of all intentional additions or removals of either edible matter or energy (except for any transport or for removal of inedible parts of food) between the harvest of ingredients and consumption of the product.

Graphical Abstract
Psychological assessment of violent behaviors in schizophrenic patients followed up in My EL Hassan health center of Kenitra, Morocco
Authors: Elyadini Bouchra , Chakit Miloud , Elkhatir Abdelkarim , Fitah Ilhame , Khadmaoui Abderazzak 
Published: September 2024

Abstract
Background
Disorders of the aggressive behavior frequently mark the entry in schizophrenia. They are not specific and very varied. The objective of this study was to assess the different risk factors associated with the manifestation of violent and aggressive behavior of schizophrenic patients who follow consultations in service of psychiatry at Kenitra, Morocco. One-hundred twenty-seven patients with schizophrenia were included, and the Modified Overt Aggression Scale (MOAS) and Positive and Negative Syndrome Scale (PANSS) were used respectively to assess the state of aggressiveness and to identify the type of psychotic symptomatology of schizophrenic patients. Clinical and sociodemographic data were obtained from all patients.

Results
The study shows that criminal history, drug addiction, motives for aggressiveness, and the moment of aggressiveness are all potential factors for aggression, and the profile of the patient likely to take the act is that of young schizophrenics under 39 years old, predominantly male, and the majority are single. Judicial history, habits toxic, and the positive psychotic symptoms are reported as the most frequently risk factors. The index of Cronbach (0.64) showed a strong connection between the four items of aggression and strong relation between MOAS and PANSS categories has been shown by independent test (p < 0.001).

Conclusion
Aggressive behavior is a frequent symptom of schizophrenia in studied population and poses many clinical challenges. It requires collaboration with the patient for handling difficult situations.
Knowledge attitude practice among oncologists and health care workers during COVID19 pandemic
Authors: Soliman Sharehan Hassan , Atef Mahinour Mohamed 
Published: September 2024

Abstract
Introduction
Healthcare providers should be well prepared to fight the COVID-19 pandemic and protect their patients and themselves as frontline workers. The aim of this study was to assess oncologists’ and health care workers (HCWs) knowledge, attitude, and practice in response to the COVID-19 pandemic and its impact on them.

Material and methods
This cross-sectional study was conducted among Egyptian oncologists and HCWs in the oncology department at Suez Canal University Hospitals, Egypt. Participants were reached through a Google Form questionnaire. The questionnaire was shared on social media (Facebook, Twitter, and WhatsApp) over four months, from June 1st to September 30, 2022. All physicians and HCWs in the oncology department were invited to participate in the survey. Researchers intended to enroll all physicians and HCWs within the study period.

Results
Out of the 110 participants included in the study, there was a female predominance, and the majority were oncology nurses and clinical oncologists. Knowledge with significant participants’ characteristics showed that knowledge significantly varied by age. The level of knowledge was significantly higher among participants between 30 and 40 years old (OR = 5.111; 95% CI, 1.202–21.738; P = 0.027). 65.5% of the participants had poor knowledge, with a mean ± SD of 4.9 ± 1.4. About 43.6% of the participants experienced more burnout than before the COVID-19 pandemic, with a negative emotional impact. 63.7% reported a negative financial impact due to the pandemic. 62.7% had support from their family, even though their job increases their risk of infection. 7.3% only reported a positive impact regarding their friend’s relationship.

Conclusion
COVID-19 pandemic has a negative impact on oncologists' personal and professional lives. Interventions should be implemented to lessen the negative impact and better prepare oncologists to handle future crises with greater efficiency and resilience.
In silico investigation of HCV and RNA synthesis inhibitor antibiotic drugs as potential inhibitors of SARS‑CoV‑2 main protease (Mpro)
Authors: Kishore Merusomayajula V. , Rao T. Siva , Kumari G. N. D. 
Published: September 2024

Abstract
Background
Since December 2019, a global crisis has unfolded with the emergence of a new strain of coronavirus known as SARS-CoV-2. This pandemic has afflicted hundreds of millions of people worldwide, resulting in millions of fatalities. In response to this urgent healthcare crisis, extensive efforts have been made to discover inhibitors of the COVID-19 virus. Given the structural similarities between SARS-CoV-2 and HCV, drugs approved by the FDA for treating HCV were selected and subjected to in silico testing against the SARS-CoV-2 virus, with Remdesivir used as the standard for validation. Drug repurposing and phytochemical testing have also been conducted to identify potential candidates capable of inhibiting or suppressing the infection caused by the coronavirus. The time constraints imposed by the pandemic necessitated the in silico analysis of existing drug molecules against the coronavirus. Eleven HCV drugs approved by the FDA, along with one RNA synthesis inhibitor antibiotic drug, were tested using the in silico method due to their structural similarities with HCV and the SARS-CoV-2 virus.

Results
Molecular docking and MD simulation studies were performed for all selected compounds. Binding energies, root-mean-square deviation, root-mean-square fluctuation, solvent-accessible surface area, radius of gyration, and molecular mechanics generalized born surface area were calculated. Based on docking and MD simulation studies all the selected compounds have shown good binding energy values with Mpro (PDB ID: 6LU7). No toxicity measurements are required for these drugs since they were previously tested prior to their approval by the FDA.

Conclusions
This study shows that FDA-approved HCV drugs can be used as for SARS-COVID-19 inhibitors.