bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compensating need satisfaction across life boundaries: A daily diary study
Authors: Hewett Rebecca , Haun Verena C. , Demerouti Evangelia , Rodríguez Sánchez Alma Maria , Skakon Janne , De Gieter Sara 
Published: February 2017

Self‐determination theory suggests that satisfaction of an individual's basic psychological needs (for competence, autonomy, and relatedness) is a key for well‐being. This has gained empirical support in multiple life domains, but little is known about the way that need satisfaction interacts between work and home. Drawing from ideas of work–home compensation, we expect that the benefits of need satisfaction in the home domain are reduced when needs are satisfied in the work domain. We tested this hypothesis with a daily diary study involving 91 workers. Results showed that individuals particularly benefit from satisfaction of their need for competence in the home domain when it is not satisfied during the working day. No such interactions were found between the needs for autonomy or relatedness. Our study highlights that the interaction of need satisfaction across domains represents a boundary condition for the beneficial effects of need satisfaction.Practitioner points

The study examines the interplay between daily need satisfaction at work and at home and its relation to employee well‐being at bedtime.

Employees particularly benefit from competence need satisfaction at home (e.g., doing a hobby which challenges them) on days when they do not get a sense of competence from their job (e.g., if the tasks are not particularly challenging, or they are underperforming).
Inhibitory effects of a standardized extract of Justicia pectoralis in an experimental rat model of airway hyper-responsiveness
Authors: Moura Carlos T M , Batista-Lima Francisco J , Brito Teresinha S , Silva Alfredo A V , Ferreira Luan C , Roque Cássia R , Aragão Karoline S , Havt Alexandre , Fonseca Francisco N , Leal Luzia K A M , Magalhães Pedro J C 
Published: February 2017

Abstract

Objective
Justicia pectoralis is a plant useful for the treatment of respiratory diseases. Here, we studied the antiasthmatic properties of a standardized extract of J. pectoralis (Jp).

Methods
Ovalbumin (OVA)-sensitized rats were actively challenged with saline or OVA to study airway hyper-responsiveness after oral treatment with saline or Jp. The ability of Jp to inhibit hyper-reactivity was evaluated in isolated trachea mounted in isolated organ bath chamber.

Key findings
Using KCl or carbachol as contractile agents, tracheal rings of OVA-challenged rats contracted with higher magnitude than trachea of rats challenged with saline. Such hyper-responsive phenotype of OVA-challenged tissues decreased with Jp administration. In Ca+-free medium, Jp or its major constituent coumarin inhibited preferentially the contractions induced by Ca2+ addition in tissues of OVA-challenged rats stimulated with KCl or acetylcholine. In tissues depleted of their internal Ca+ stores in the presence of thapsigargin, Jp inhibited the contraction induced by capacitative Ca2+ entry. By gavage, Jp abolished the increase caused by challenge with OVA on the levels of IL-1β and TNF-α in the bronchoalveolar fluid and also impaired the changes in gene expression of canonical transient receptor proteins.

Conclusions
Jp has antiasthmatic properties in an experimental model that reproduces tracheal hyper-reactivity.
Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux
Authors: Subbotina Anna , Ravna Aina W , Lysaa Roy A , Abagyan Ruben , Bugno Ryszard , Sager Georg 
Published: February 2017

Abstract

Objectives
To determine the ability of 11 sildenafil analogues to discriminate between cyclic nucleotide phosphodiesterases (cnPDEs) and to characterise their inhibitory potencies (Ki values) of PDE5A1-dependent guanosine cyclic monophosphate (cGMP) hydrolysis.

Methods
Sildenafil analogues were identified by virtual ligand screening (VLS) and screened for their ability to inhibit adenosine cyclic monophosphate (cAMP) hydrolysis by PDE1A1, PDE1B1, PDE2A1, PDE3A, PDE10A1 and PDE10A2, and cGMP hydrolysis by PDE5A, PDE6C, PDE9A2 for a low (1 nm) and high concentration (10 μm). Complete IC50 plots for all analogues were performed for PDE5A-dependent cGMP hydrolysis. Docking studies and scoring were made using the ICM molecular modelling software.

Key findings
The analogues in a low concentration showed no or low inhibition of PDE1A1, PDE1B1, PDE2A1, PDE3A, PDE10A1 and PDE10A2. In contrast, PDE5A and PDE6C were markedly inhibited to a similar extent by the analogues in a low concentration, whereas PDE9A2 was much less inhibited. The analogues showed a relative narrow range of Ki values for PDE5A inhibition (1.2–14 nm). The sildenafil molecule was docked in the structure of PDE5A1 co-crystallised with sildenafil. All the analogues had similar binding poses as sildenafil.

Conclusions
Sildenafil analogues that inhibit cellular cGMP efflux are potent inhibitors of PDE5A and PDE6C.
Sensory effects of transient receptor potential channel agonists on whole mouth saliva extensional rheology
Authors: Houghton Jack William , Hans Joachim , Pesaro Manuel , Ley Jakob Peter , Carpenter Guy Howard , Proctor Gordon 
Published: February 2017

AbstractThe extensional rheology (ER) of saliva is a property associated with its ability to coat surfaces and is important for the maintenance of a normal mouth feeling. Transient receptor potential (TRP) channels are expressed in the oral cavity and this study investigated how the sensory effects of TRP channel agonists modify the ER of saliva. Healthy volunteers rinsed with solutions containing a TRP agonist. Unstimulated whole mouth saliva (WMS) was collected prior to rinsing and WMS was collected during the first and second minutes after the mouth rinse. The Spinnbarkeit of the collected saliva was measured using a Neva Meter. The nonivamide (TRPV1) mouth rinse increased WMS ER from 37.0 (± 6.3) mm to 49.3 (± 5.1) mm when compared with the vehicle control, which itself had no effect on WMS ER. However, this effect was short‐lived and ER of WMS was not increased in the second minute after the nonivamide mouth rinse. The menthol (TRPM8) mouth rinse resulted in an increase up to 57.8 (± 7.8) mm in WMS ER from the vehicle control and returned to control levels in the second minute. The cinnamaldehyde (TRPA1) mouth rinse resulted in no change in WMS ER. It can be concluded that nonivamide and menthol mouth rinsing has a short‐term effect of increasing WMS ER, an effect not observed after cinnamaldehyde rinsing. We hypothesize that the activation of some TRP channels in the oral cavity results in changes in the salivary protein composition that in turn alters WMS ER.Practical applicationsIdentifying compounds that modify the physical properties of saliva in a desirable way is important in developing treatments for conditions associated with changes in the physical properties of saliva such as xerostomia (also known as dry mouth). Furthermore, understanding the rheology of saliva contributes to the elucidation of food oral processing which is of importance to food manufacturers.
Serum microRNAs as predictors for liver fibrosis staging in hepatitis C virus‐associated chronic liver disease patients
Authors: Shaker O. G. , Senousy M. A. 
Published: February 2017

SummaryAccurate staging of liver fibrosis is important for clinical decision making and personalized management. Liver fibrosis is influenced by patients’ genomics, including IFNL3 genotype and microRNA expression. However, incorporating microRNAs into fibrosis prediction algorithms has not been investigated. We examined the potential of eight selected serum microRNAs; miR‐122, miR‐126, miR‐129, miR‐199a, miR‐155, miR‐203a, miR‐221, and miR‐223 as non‐invasive biomarkers to stage liver fibrosis in HCV‐associated chronic liver disease (HCV‐CLD). 145 Egyptian HCV‐CLD patients were divided according to Metavir fibrosis scores. MicroRNAs and IFNL3 rs12979860 genotype were assayed by RT‐qPCR and allelic discrimination techniques, respectively. Serum miR‐122 was downregulated, whereas miR‐203a and miR‐223 were upregulated in significant fibrosis (≥F2) compared with no/mild fibrosis (F0‐F1). Serum miR‐126, miR‐129, miR‐203a, and miR‐223 were upregulated in severe fibrosis (≥F3) and cirrhosis (F4) compared with F0‐F2 and F0‐F3, respectively. miR‐221 was upregulated in ≥F3, but unchanged in F4. miR‐155, miR‐199a, and IFNL3 rs12979860 genotype were not significantly different in all comparisons. Differentially expressed serum microRNAs discriminated ≥F2, ≥F3, and F4 by receiver‐operating‐characteristic analysis. Multivariate logistic analysis revealed a model combining miR‐129, miR‐223, AST, and platelet count with high diagnostic accuracy for ≥F3 (AUC=0.91). The model also discriminated F4 (AUC=0.96) and ≥F2 (AUC=0.783), and was superior to APRI and FIB‐4 in discriminating ≥F3 and F4, but not ≥F2. In conclusion, combining serum microRNAs with baseline predictors could serve as a new non‐invasive algorithm for staging HCV‐associated liver fibrosis. Additional studies are required to confirm this model and test its significance in liver fibrosis of other etiologies.
Antibiotic resistance in Escherichia coli in husbandry animals: the African perspective
Authors: Alonso C.A. , Zarazaga M. , Ben Sallem R. , Jouini A. , Ben Slama K. , Torres C. 
Published: February 2017

Abstract
In the last few years, different surveillances have been published in Africa, especially in northern countries, regarding antimicrobial resistance among husbandry animals. Information is still scarce, but the available data show a worrying picture. Although the highest resistance rates have been described against tetracycline, penicillins and sulphonamides, prevalence of plasmid-mediated quinolone resistance genes and extended spectrum β-lactamase (ESBL) are being increasingly reported. Among ESBLs, the CTX-M-1 group was dominant in most African surveys. Within this group, CTX-M-15 was the main variant both in animals and humans, except in Tunisia where CTX-M-1 was more frequently detected among Escherichia coli from poultry. Certain blaCTX-M-15-harbouring clones (ST131/B2 or ST405/D) are mainly identified in humans, but they have also been reported in livestock species from Tanzania, Nigeria or Tunisia. Moreover, several reports suggest an inter-host circulation of specific plasmids (e.g. blaCTX-M-1-carrying IncI1/ST3 in Tunisia, IncY- and Inc-untypeable replicons co-harbouring qnrS1 and blaCTX-M-15 in Tanzania and the worldwide distributed blaCTX-M-15-carrying IncF-type plasmids). International trade of poultry meat seems to have contributed to the spread of other ESBL variants, such as CTX-M-14, and clones. Furthermore, first descriptions of OXA-48- and OXA-181-producing E. coli have been recently documented in cattle from Egypt, and the emergent plasmid-mediated colistin resistance mcr-1 gene has been also identified in chickens from Algeria, Tunisia and South Africa. These data reflect the urgent need of a larger regulation in the use of veterinary drugs and the implementation of surveillance programmes in order to decelerate the advance of antimicrobial resistance in this continent.
What We Gain by Combining Variationist and Concept‐Oriented Approaches: The Case of Acquiring Spanish Future‐Time Expression
Authors: Kanwit Matthew 
Published: February 2017

AbstractThis study aimed to advance research on first and second language future‐time expression in Spanish and to demonstrate the strengths of combining functionalist, concept‐oriented approaches (e.g., Andersen, 1984; Bardovi‐Harlig, 2000; Shirai, 1995; von Stutterheim & Klein, 1987) with variationist approaches. The study targeted 140 participants (120 English‐speaking learners of Spanish of varying proficiency and 20 native speakers of Spanish) who completed an oral task responding to eight prompts (e.g., describe tus planes para este fin de semana “describe your plans for this weekend”). Results from cross‐tabulations and multinomial regressions indicated gradual inclusion of new linguistic and social variables as learner proficiency increased and demonstrated the value of considering both group and individual behavior. Findings were discussed in relation to stages of acquisition of future‐time expression.Open PracticesThis article has been awarded an Open Materials badge. All materials are publicly accessible in the IRIS digital repository at http://www.iris-database.org. Learn more about the Open Practices badges from the Center for Open Science: https://osf.io/tvyxz/wiki.
Renal replacement therapy in critically ill liver cirrhotic patients—outcome and clinical implications
Authors: Staufer Katharina , Roedl Kevin , Kivaranovic Danijel , Drolz Andreas , Horvatits Thomas , Rasoul‐Rockenschaub Susanne , Zauner Christian , Trauner Michael , Fuhrmann Valentin 
Published: February 2017

AbstractBackground & AimsCurrent guidelines discourage renal replacement therapy (RRT) in critically ill cirrhotics in the lack of liver transplant (LT) options. This study aimed to identify patients who benefit from RRT in the short and long‐term.MethodsCritically ill cirrhotics were included over a time period of 6 years and followed for at least 1 year. CLIF‐C ACLF, CLIF‐SOFA, SOFA and MELD scores on admission, 24 h prior to RRT, 24 and 48 hours after start of RRT were analysed for their predictive value of ICU‐mortality. Additionally, long‐term renal recovery and successful bridging to LT was assessed.ResultsIn total, 40% (78/193) of patients required RRT. ICU‐, 28 days‐, 90 days‐, and 1 year‐mortality was 71%, 83%, 91%, and 92%, respectively, and was significantly higher than in patients without need for RRT (4%, 30%, 43%, and 50%), P<.001. CLIF‐C ACLF and CLIF – SOFA scores within 24 hours prior to RRT showed good discriminant power to predict ICU‐mortality. CLIF‐C ACLF calculated 48 hours after commencing RRT was the most suitable predictor of ICU‐mortality in RRT‐patients irrespective of LT options (AUC: 0.866). In patients with ≥5 organ failure assessed by CLIF‐SOFA at any time point showed 100% ICU‐mortality. 13% of patients with RRT showed renal recovery; 14% of patients could be bridged to LT.ConclusionsMortality in critically ill cirrhotics with need for RRT is substantially high independent of LT options. Only a small proportion showed renal recovery after ICU discharge. CLIF‐C ACLF and CLIF‐SOFA score may assist in identifying patients who would not benefit from RRT.
Origin and transportation history of lunar breccia 14311
Authors: Merle Renaud E. , Nemchin Alexander A. , Whitehouse Martin J. , Pidgeon Robert T. , Grange Marion L. , Snape Joshua F. , Thiessen Fiona 
Published: February 2017

AbstractIn this paper, we compare the U‐Pb zircon age distribution pattern of sample 14311 from the Apollo 14 landing site with those from other breccias collected at the same landing site. Zircons in breccia 14311 show major age peaks at 4340 and 4240 Ma and small peaks at 4110, 4030, and 3960 Ma. The zircon age patterns of breccia 14311 and other Apollo 14 breccias are statistically different suggesting a separate provenance and transportation history for these breccias. This interpretation is supported by different U‐Pb Ca‐phosphate and exposure ages for breccia 14311 (Ca‐phosphate age: 3938 ± 4 Ma, exposure age: ~550–660 Ma) from the other Apollo 14 breccias (Ca‐phosphate age: 3927 ± 2 Ma, compatible with the Imbrium impact, exposure age: ~25–30 Ma). Based on these observations, we consider two hypotheses for the origin and transportation history of sample 14311. (1) Breccia 14311 was formed in the Procellarum KREEP terrane by a 3938 Ma‐old impact and deposited near the future site of the Imbrium basin. The breccia was integrated into the Fra Mauro Formation during the deposition of the Imbrium impact ejecta at 3927 Ma. The zircons were annealed by mare basalt flooding at 3400 Ma at Apollo 14 landing site. Eventually, at approximately 660 Ma, a small and local impact event excavated this sample and it has been at the surface of the Moon since this time. (2) Breccia 14311 was formed by a 3938 Ma‐old impact. The location of the sample is not known at that time but at 3400 Ma, it was located nearby or buried by hot basaltic flows. It was transported from where it was deposited to the Apollo 14 landing site by an impact at approximately 660 Ma, possibly related to the formation of the Copernicus crater and has remained at the surface of the Moon since this event. This latter hypothesis is the simplest scenario for the formation and transportation history of the 14311 breccia.
What can genome‐wide association studies tell us about the evolutionary forces maintaining genetic variation for quantitative traits?
Authors: Josephs Emily B. , Stinchcombe John R. , Wright Stephen I. 
Published: February 2017

SummaryUnderstanding the evolutionary forces that shape genetic variation within species has long been a goal of evolutionary biology. Integrating data for the genetic architecture of traits from genome‐wide association mapping studies (GWAS) along with the development of new population genetic methods for identifying selection in sequence data may allow us to evaluate the roles of mutation–selection balance and balancing selection in shaping genetic variation at various scales. Here, we review the theoretical predictions for genetic architecture and additional signals of selection on genomic sequence for the loci that affect traits. Next, we review how plant GWAS have tested for the signatures of various selective scenarios. Limited evidence to date suggests that within‐population variation is maintained primarily by mutation–selection balance while variation across the landscape is the result of local adaptation. However, there are a number of inherent biases in these interpretations. We highlight these challenges and suggest ways forward to further understanding of the maintenance of variation.ContentsSummary21I.Introduction21II.Theoretical predictions22III.What GWAS have told us about selection on quantitative traits24IV.Challenges of connecting GWAS to selection25V.Potential ways forward29Acknowledgements30References30
Biogeography of nodulated legumes and their nitrogen‐fixing symbionts
Authors: Sprent Janet I. , Ardley Julie , James Euan K. 
Published: February 2017

Contents

Summary
40

I.
Introduction
40

II.
Recent changes in the taxonomy of legume genera
41

III.
Latitudinal variations in the distribution of nodulated legumes
44

IV.
Longitudinal variations in the distribution of nodulated legumes
48

V.
Evolution of legume nodulation
49

VI.
Legume‐nodulating bacteria – rhizobial diversity in a geographical context
49

VII.
Host plant control of rhizobia – the Inverted Repeat Lacking Clade (IRLC) legumes
52

VIII.
Conclusions and outstanding problems
53

Acknowledgements
53

References
53

SummaryIn the last decade, analyses of both molecular and morphological characters, including nodulation, have led to major changes in our understanding of legume taxonomy. In parallel there has been an explosion in the number of genera and species of rhizobia known to nodulate legumes. No attempt has been made to link these two sets of data or to consider them in a biogeographical context. This review aims to do this by relating the data to the evolution of the two partners: it highlights both longitudinal and latitudinal trends and considers these in relation to the location of major land masses over geological time. Australia is identified as being a special case and latitudes north of the equator as being pivotal in the evolution of highly specialized systems in which the differentiated rhizobia effectively become ammonia factories. However, there are still many gaps to be filled before legume nodulation is sufficiently understood to be managed for the benefit of a world in which climate change is rife.
Systematic review and meta‐analysis of the association of Autism Spectrum Disorder in visually or hearing impaired children
Authors: Do Belinda , Lynch Paige , Macris Elena‐Marie , Smyth Brianna , Stavrinakis Stephanie , Quinn Stephen , Constable Paul A 
Published: February 2017

AbstractPurposeTo determine whether there is an association with a congenital visual or hearing impairment (VIorHI) and Autism Spectrum Disorder (ASD) in children.MethodsA systematic literature review was performed using nine relevant databases limited to peer reviewed articles in English between 1994 and January 2016. The search identified 1248 articles after duplicates were removed with subsequent screening of the abstracts excluding a further 1199, resulting in 49 full‐text articles that were then independently assessed by five of the authors with a final 15 articles meeting the inclusion criteria. Bias assessment was determined through consensus of the first five authors. A meta‐analysis of the included studies was performed to estimate the relative risk ofASDin theVIandHIgroups compared to the general population based on reported prevalence rates in similar geographical regions. Overall prevalence rates forASDwere calculated from the combined studies in theVIandHIpopulations.ResultsThe overall prevalence ofASDinVIandHIpopulations was 19% (95%CI13–25%) and 9% (95%CI6–12%) respectively. The overall risk‐ratio ofASDwas greater in theVI31.0 times (95%CI18.62–51.56);z = 13.21,p < 0.001) andHIgroups 14.1 times (95%CI3.41–58.62;z = 3.65,p < 0.001) compared to reportedASDprevalence in the general population.ConclusionThere is a high association ofASDinVIorHIchildren and therefore these populations should be assessed forASDin the presence of a visual or hearing disability.