bluuebunny/crossref_metadata_2025_split huggingface dataset:
Steel‐to‐concrete joints with large anchor plates under shear loading
Authors: Ruopp Jakob , Kuhlmann Ulrike 
Published: May 2017

AbstractIn industry and plant engineering especially, high flexibility is required at joints between steel and concrete. According to current standards, the maximum number of fasteners is limited to an arrangement of 3 × 3 anchors on an anchor plate. The load‐carrying behaviour of large anchor plates under tension, shear and restraining forces was investigated within the scope of the research project ”Large Anchor Plates with Headed Studs for Highly Stressed Constructions in Industry and Plant Engineering“. This paper describes the research results obtained at the University of Stuttgart for large anchor plates under shear loading. Findings for large anchor plates under tension and restraining forces are given in [20], which were mainly investigated at the University of Kaiserslautern.The shear behaviour and distribution of forces within the anchor plate are crucial issues in the development of a design concept for steel‐to‐concrete joints with large anchor plates. The influence of different parameters, such as the dimensions of the anchor plate, the embedment depth of the headed studs or the eccentricity of the shear force, have been studied in several test series. Supplementary reinforcement was placed close to the headed studs in tension to strengthen the load‐carrying capacity of the joint. The distribution of the shear forces has been assessed by means of numerical investigations together with the influence of further parameters such as concrete strength and reinforcement ratio. With regard to the load distribution within the anchor plate, elastic and plastic design approaches have been taken into account.Based on these studies, a suitable design model has been developed for steel‐to‐concrete joints with large anchor plates and a higher number of fasteners than originally permitted. Owing to the consideration of supplementary reinforcement, in addition to the plastic design approach, an alternative economical solution is given which links the component method according to EN 1993‐1‐8 to the fastener technique according to EN 1992‐4.
FE validation of push‐out tests
Authors: Pavlović Marko , Veljković Milan 
Published: May 2017

AbstractThe prefabrication of concrete slabs reduces construction time and the total life cycle cost of composite steel‐concrete buildings and bridge decks. Using bolts as shear connectors embedded in prefabricated concrete slabs enables reuse and easy replacement of slabs as structural members suitable for a circular economy construction concept. The results of static push‐out experiments on M16 and M24 bolts, grade 8.8, are shown here. The focus is on the validation of advanced finite element (FE) modelling by experiments. Damage material models for bolt and concrete slab were used and the most realistic preloading of the bolts modelled with threads was achieved by turning the nut in the FE model. An explicit dynamic solver with mass scaling function was used for quasi‐static analysis including fracture. Two failure modes obtained in experiments – bolt shear and concrete crushing – were realistically modelled by the FEA, which shows that the model is suitable for a parametric study leading to theoretical models of failure modes and slip capacity of the shear connection. Results indicate that the bolts with nuts on both sides of the steel flange can be successfully used as demountable shear connectors.
The model for a general composite section resulting from the introduction of composite dowels
Authors: Lorenc Wojciech 
Published: May 2017

AbstractA new form of shear connection, so‐called composite dowels, first appeared in Europe in last decade. It enabled economic construction of steel‐concrete composite bridges without an upper steel flange, using a direct connection between steel web and concrete slab. It finally resulted in new economic structural forms and composite sections that had not been used in bridge engineering before. In 2010 the European Commission launched an international project to build three different innovative bridges in three different European countries (Germany, Poland, Romania). Each bridge project was supported by a national consortium consisting of design office, general contractor and university. This economic technology has developed fast: by the end of 2016, at least 34 bridges using composite dowels had been constructed in Europe (13 in Germany, 11 in Poland, 4 in Czech Republic, 4 in Austria, 2 in Romania). These structures use different kinds of composite section that in many cases are not covered by standard design procedures for composite structures. The need for a consistent design method was evident. This leads to a clear design concept that covers the contribution of concrete slabs in transmitting part of the vertical force in composite sections and finally breaks with the concept of a ”steel skeleton“ constituting the fundamental part of the composite beam. The approach proposed here needs to be as simple and clear as possible, so it assumes some simplifications at this stage. It is intended to cover many types of composite section, externally reinforced section and conventional composite section.
Large web openings in steel and composite beams
Authors: Lawson R. Mark , Hanus Francois , Sonck Delphine 
Published: May 2017

AbstractThis paper presents the basis for the design of steel and composite beams with large web openings. The main design requirements are the transfer of shear by Vierendeel bending and the control of web buckling next to and between the openings. Cellular beams with regular circular openings are a common example of highly perforated beams and their flange areas are often highly asymmetric. For these beams, web‐post moments may be generated to develop the full shear resistance of the cross‐section.Tests on beams with circular, elongated circular and rectangular openings are presented which are used to verify the design methodology. In addition, the openings cause local displacements due to shear and bending, which add to the overall deflection of perforated beams. Simplified formulae are presented to determine the additional deflection relative to the equivalent solid‐web beams.
Phenolic Profile of Peanut By‐products: Antioxidant Potential and Inhibition of Alpha‐Glucosidase and Lipase Activities
Authors: de Camargo Adriano Costa , Regitano‐d’Arce Marisa Aparecida Bismara , Shahidi Fereidoon 
Published: May 2017

AbstractFree, esterified, etherified and insoluble‐bound phenolics from three samples, namely meal from whole peanuts (MWP), meal from dry‐blanched peanuts (MDBP) and peanut skin (PS) were evaluated for their total phenolic content (TPC), and phenolic profile using HPLC–DAD–ESI–MSn. The TPC was in the order of PS > MWP > MDBP. Among 37 compounds identified 10 were reported for peanuts for the first time. Proanthocyanidins were detected in peanut skin and MWP, but not in MDBP. The presence of peanut skin in MWP rendered up to 9.8‐fold higher scavenging activity towards the DPPH radical as compared with MDBP. Phenolics from all samples and fractions showed inhibition of alpha‐glucosidase and lipase activities, which are key enzymes involved in the absorption of glucose and triacylglycerols, respectively. Therefore, their antioxidant properties as well as their potential role in the management of diabetes and obesity makes them worthy of further consideration as functional food ingredients.
Transition induced by linear and nonlinear perturbation growth in flow past a compressor blade
Authors: Mao X. , Zaki T. A. , Sherwin S. J. , Blackburn H. M. 
Published: May 2017

Flow past a NACA 65 blade at chord-based Reynolds number 138 500 is studied using stability analysis, generalized (spatially weighted) transient growth analysis and direct numerical simulations (DNS). The mechanisms of transition on various sections of the blade observed in previous work by Zaki et al. (J. Fluid Mech., vol. 665, 2010, pp. 57–98) are examined, with a focus on the pressure side around the leading edge. In this region, the linearly most energetic perturbation has spanwise wavenumber $40\unicode[STIX]{x03C0}$ (five boundary-layer thicknesses) and is tilted against the mean shear to take advantage of the Orr mechanism. In a DNS, the nonlinear development of this optimal perturbation induces $\unicode[STIX]{x1D6EC}$ structures, which are further stretched to hairpin vortices before breaking down to turbulence. At higher spanwise wavenumber, e.g. $120\unicode[STIX]{x03C0}$, a free-stream optimal perturbation is obtained upstream of the leading edge, in the form of streamwise vortices. During its nonlinear evolution, this optimal perturbation tilts the mean shear and generates spanwise periodic high- and low-speed streaks. Then through a nonlinear lift-up mechanism, the low-speed streaks are lifted above the high-speed ones. This layout of streaks generates a mean shear with two inflectional points and activates secondary instabilities, namely inner and outer instabilities previously reported in the literature.
Carbon Reservoir Effects in Eastern Oyster from Apalachicola Bay, USA
Authors: Hadden Carla S , Cherkinsky Alexander 
Published: May 2017

AbstractEastern oyster (Crassostrea virginica) is an ubiquitous estuarine shellfish taxon in eastern North America and one of the most abundant materials available for radiocarbon (14C) dating. We examine spatiotemporal variability in carbon reservoir effects among pre-bomb oysters from Apalachicola Bay, USA, a river-influenced estuary on the northern Gulf of Mexico. Shells were sampled at multiple points along the valve to produce time-series records of14C variation during the lives of the mollusks. Conventional ages within shells differed by as little as 3614C yr to as much as 29514C yr. Reservoir offsets varied sub-regionally within the estuary, increasing from 92±37 yr in the eastern edge of study region to 227±110 yr in the west, reflecting the influence of14C-depleted dissolved inorganic carbon from the Apalachicola River. Dynamic carbon reservoirs can pose problems for the estimation of ΔR and for building coastal chronologies. Estimating sub-regional ΔR values can be useful for assessing the range of variability in reservoir offsets within an estuary, and for correcting sample ages if the shell origin is known. Greater variability and/or uncertainty in ΔR lead to greater uncertainty in the calibrated age.
Law and compassion
Authors: Feenan Dermot 
Published: May 2017

AbstractThis paper provides the first overarching exploration and discussion of the relationship between law and compassion, based on a broad review of law and associated literature. The paper reviews the English-language literature worldwide, identifying and analysing key themes. It lays out a number of themes by which the relationship may be examined, including the problematic of defining compassion, addressing the concept of compassion, its components, to whom it is owed and under what conditions it is owed. The paper reviews how compassion is defined in formal law, including in case-law and legislation across a range of common-law and civil-law countries, and in international human rights and humanitarian law−revealing various judicial and legislative approaches to the place, meaning and application of compassion. The discussion of primary and secondary sources suggests a number of ways of thinking about the place or absence of compassion in law: how it helps theorise law, including its normative presuppositions and the conceptualisation of law. The paper concludes with consideration of possible pathways for future research on law and compassion.
Compassion and the rule of law
Authors: Bandes Susan A. 
Published: May 2017

AbstractCompassion poses difficult challenges for the rule of law. The compassionate response is often cast as a deviation from settled law rather than a principled application of it. Compassion so understood is troubling, most obviously because it poses a challenge to overall fairness, notice and consistency. Although compassion is usually approached as a factor influencing substantive outcomes, I argue to the contrary that compassion cannot serve as a reliable indicator of who should prevail in legal debates. Whether compassion should inform substance is a normative question that must be answered in light of the purposes of the tribunal and the principles it seeks to advance. I propose instead that compassion's importance lies in its ability to aid decision-makers in understanding what is at stake for the litigant. In this sense, compassion is closely tied to humility: both are reminders of human fallibility and of the limits of individual understanding.
Merkmale und prädiktiver Wert von früher Verschlechterung in der ambulanten Psychotherapie
Authors: Schlagert Henrike Stephanie , Hiller Wolfgang 
Published: May 2017

Zusammenfassung. Theoretischer Hintergrund: Trotz des anhaltenden Forschungsinteresses an frühen Therapieerfolgen (Early Response), wurden frühe Verschlechterungen in bisherigen Untersuchungen eher vernachlässigt. Fragestellung: Diese Studie untersucht Merkmale und prädiktive Qualität einer frühen Verschlechterung für das Behandlungsergebnis in einer verhaltenstherapeutischen Hochschulambulanz. Methode: 1983 Patienten wurden anhand des Reliable Change Indexes (RCI) auf das Vorliegen einer frühen Verschlechterung der psychischen Belastung überprüft. Ergebnisse: Es fanden sich nur wenige charakteristische Merkmale einer frühen Verschlechterung (z. B. höhere Anzahl psychischer Störungen). Sich früh verschlechternde Patienten erreichten seltener Response (OR = 7,45) beziehungsweise Remission (OR = 11,43) und zeigten häufiger Verschlechterungen (OR = 40,68) und pathologische Abschlusswerte (OR = 5,02) zu Therapieende. Schlussfolgerung: Verschlechterungen in der frühen Therapiephase sind mit negativen Behandlungsresultaten assoziiert und sollten bei der Behandlungsplanung ambulanter Psychotherapien berücksichtigt werden.
Die Wirksamkeit psychotherapeutischer Behandlung von Sexualstraftätern nach Entlassung aus dem Strafvollzug
Authors: Keßler Achim , Rettenberger Martin 
Published: May 2017

Zusammenfassung. Hintergrund: Das zentrale Wirkkriterium forensischer Psychotherapie besteht in der Verringerung des Rückfallrisikos hinsichtlich neuerlicher Straftaten. In der vorliegenden Studie wurde die in Hessen dezentral organisierte psychotherapeutische Versorgung von Personen, die aufgrund sexuell motivierter Straftaten verurteilt wurden, evaluiert. Methoden: Hierfür wurden psychotherapeutisch behandelte Probanden (n = 134) mit psychotherapeutisch nicht behandelten Probanden (n = 134) hinsichtlich der Rückfälligkeit verglichen, wobei die Vergleichbarkeit beider Gruppen mittels eines Matching-Verfahrens bezüglich rückfallrisikorelevanter Merkmale sichergestellt wurde. Der Behandlungserfolg wurde mit Hilfe zweier Rückfalldatenquellen überprüft: Erneut eingegangene Anzeigen bei der Staatsanwaltschaft sowie Wiederverurteilung und erneute Eintragung im Bundeszentralregister (BZR). Ergebnisse: Behandelte Probanden wiesen hinsichtlich allgemein gewalttätiger und sexuell motivierter Rückfälle signifikant niedrigere Anzeigeraten auf (14.2 % bzw. 9.7 %) als die unbehandelten Vergleichsprobanden (26.9 % bzw. 19.4 %), wobei bei den übrigen Rückfallkriterien die Signifikanzgrenze nicht erreicht wurde. Diskussion: Die Ergebnisse der vorliegenden Studie verdeutlichen, dass auch eine dezentral organisierte Versorgungsstruktur grundsätzlich geeignet ist, zur Verhinderung von Rückfällen von entlassenen Sexualstraftätern beizutragen.
Comparative transcriptomics analyses reveal the conservation of an ancestral infectious strategy in two bacteriophage genera
Authors: Blasdel Bob G , Chevallereau Anne , Monot Marc , Lavigne Rob , Debarbieux Laurent 
Published: May 2017

Abstract
Although the evolution of tailed bacteriophages has increasingly been better understood through comparisons of their DNA sequences, the functional consequences of this evolution on phage infectious strategies have remained unresolved. In this study, we comprehensively compared the transcriptional strategies of two related myoviruses, PAK_P3 and PAK_P4, infecting the same Pseudomonas aeruginosa host strain. Outside of the conservation of their structural clusters, their highly syntenic genomes display only limited DNA similarity. Despite this apparent divergence, we found that both viruses follow a similar infection scheme, relying on a temporal regulation of their gene expression, likely involving the use of antisense transcripts, as well as a rapid degradation of 90% of the host non-ribosomal mRNA, as previously reported for PAK_P3. However, the kinetics of the mRNA degradation is remarkably faster during PAK_P4 infection. Moreover, we found that each virus has evolved specific adaptations, as exemplified by the distinct patterns of their core genes expression as well as the specific manipulation of the expression of iron-related host genes by PAK_P4. This study enhances our understanding of the evolutionary process of virulent phages, which relies on adjusting globally conserved ancestral infection mechanisms.
A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs
Authors: Melero-Fernandez de Mera Raquel M. , Li Li-Li , Popinigis Arkadiusz , Cisek Katryna , Tuittila Minna , Yadav Leena , Serva Andrius , Courtney Michael J. 
Published: May 2017

AbstractEngineering light-sensitive protein regulators has been a tremendous multidisciplinary challenge. Optogenetic regulators of MAPKs, central nodes of cellular regulation, have not previously been described. Here we present OptoJNKi, a light-regulated JNK inhibitor based on the AsLOV2 light-sensor domain using the ubiquitous FMN chromophore. OptoJNKi gene-transfer allows optogenetic applications, whereas protein delivery allows optopharmacology. Development of OptoJNKi suggests a design principle for other optically regulated inhibitors. From this, we generate Optop38i, which inhibits p38MAPK in intact illuminated cells. Neurons are known for interpreting temporally-encoded inputs via interplay between ion channels, membrane potential and intracellular calcium. However, the consequences of temporal variation of JNK-regulating trophic inputs, potentially resulting from synaptic activity and reversible cellular protrusions, on downstream targets are unknown. Using OptoJNKi, we reveal maximal regulation of c-Jun transactivation can occur at unexpectedly slow periodicities of inhibition depending on the inhibitor’s subcellular location. This provides evidence for resonance in metazoan JNK-signalling circuits.
Pore configuration landscape of granular crystallization
Authors: Saadatfar M. , Takeuchi H. , Robins V. , Francois N. , Hiraoka Y. 
Published: May 2017

AbstractUncovering grain-scale mechanisms that underlie the disorder–order transition in assemblies of dissipative, athermal particles is a fundamental problem with technological relevance. To date, the study of granular crystallization has mainly focussed on the symmetry of crystalline patterns while their emergence and growth from irregular clusters of grains remains largely unexplored. Here crystallization of three-dimensional packings of frictional spheres is studied at the grain-scale using X-ray tomography and persistent homology. The latter produces a map of the topological configurations of grains within static partially crystallized packings. Using numerical simulations, we show that similar maps are measured dynamically during the melting of a perfect crystal. This map encodes new information on the formation process of tetrahedral and octahedral pores, the building blocks of perfect crystals. Four key formation mechanisms of these pores reproduce the main changes of the map during crystallization and provide continuous deformation pathways representative of the crystallization dynamics.
Using shape to turn off blinking for two-colour multiexciton emission in CdSe/CdS tetrapods
Authors: Mishra Nimai , Orfield Noah J. , Wang Feng , Hu Zhongjian , Krishnamurthy Sachidananda , Malko Anton V. , Casson Joanna L. , Htoon Han , Sykora Milan , Hollingsworth Jennifer A. 
Published: May 2017

AbstractSemiconductor nanostructures capable of emitting from two excited states and thereby of producing two photoluminescence colours are of fundamental and potential technological significance. In this limited class of nanocrystals, CdSe/CdS core/arm tetrapods exhibit the unusual trait of two-colour (red and green) multiexcitonic emission, with green emission from the CdS arms emerging only at high excitation fluences. Here we show that by synthetic shape-tuning, both this multi-colour emission process, and blinking and photobleaching behaviours of single tetrapods can be controlled. Specifically, we find that the properties of dual emission and single-nanostructure photostability depend on different structural parameters—arm length and arm diameter, respectively—but that both properties can be realized in the same nanostructure. Furthermore, based on results of correlated photoluminescence and transient absorption measurements, we conclude that hole-trap filling in the arms and partial state-filling in the core are necessary preconditions for the observation of multiexciton multi-colour emission.
L-selectin mechanochemistry restricts neutrophil priming in vivo
Authors: Liu Zhenghui , Yago Tadayuki , Zhang Nan , Panicker Sumith R. , Wang Ying , Yao Longbiao , Mehta-D’souza Padmaja , Xia Lijun , Zhu Cheng , McEver Rodger P. 
Published: May 2017

AbstractCirculating neutrophils must avoid premature activation to prevent tissue injury. The leukocyte adhesion receptor L-selectin forms bonds with P-selectin glycoprotein ligand-1 (PSGL-1) on other leukocytes and with peripheral node addressin (PNAd) on high endothelial venules. Mechanical forces can strengthen (catch) or weaken (slip) bonds between biological molecules. How these mechanochemical processes influence functionin vivois unexplored. Here we show that mice expressing an L-selectin mutant (N138G) have altered catch bonds and prolonged bond lifetimes at low forces. Basal lymphocyte homing and neutrophil recruitment to inflamed sites are normal. However, circulating neutrophils form unstable aggregates and are unexpectedly primed to respond robustly to inflammatory mediators. Priming requires signals transduced through L-selectin N138G after it engages PSGL-1 or PNAd. Priming enhances bacterial clearance but increases inflammatory injury and enlarges venous thrombi. Thus, L-selectin mechanochemistry limits premature activation of neutrophils. Our results highlight the importance of probing how mechanochemistry functionsin vivo.
Face classification using electronic synapses
Authors: Yao Peng , Wu Huaqiang , Gao Bin , Eryilmaz Sukru Burc , Huang Xueyao , Zhang Wenqiang , Zhang Qingtian , Deng Ning , Shi Luping , Wong H.-S. Philip , Qian He 
Published: May 2017

AbstractConventional hardware platforms consume huge amount of energy for cognitive learning due to the data movement between the processor and the off-chip memory. Brain-inspired device technologies using analogue weight storage allow to complete cognitive tasks more efficiently. Here we present an analogue non-volatile resistive memory (an electronic synapse) with foundry friendly materials. The device shows bidirectional continuous weight modulation behaviour. Grey-scale face classification is experimentally demonstrated using an integrated 1024-cell array with parallel online training. The energy consumption within the analogue synapses for each iteration is 1,000 × (20 ×) lower compared to an implementation using Intel Xeon Phi processor with off-chip memory (with hypothetical on-chip digital resistive random access memory). The accuracy on test sets is close to the result using a central processing unit. These experimental results consolidate the feasibility of analogue synaptic array and pave the way toward building an energy efficient and large-scale neuromorphic system.