bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors for venous sinus stent retreatment in patients with idiopathic intracranial hypertension
Authors: El Mekabaty Amgad , Obuchowski Nancy A , Luciano Mark G , John Seby , Chung Charlotte Y , Moghekar Abhay , Jones Stephen , Hui Ferdinand K 
Published: December 2016

BackgroundVenous sinus stenting for dural sinus stenoses is an emerging alternative to cerebrospinal fluid diversion in cases of medically refractory idiopathic intracranial hypertension. Juxta-stent ‘re-stenoses’ have been reported and managed alternatively with ventricular shunting or stent revision. Identification of factors that might predispose patients to recurrent narrowing may help to select or exclude patients with idiopathic intracranial hypertension for venous sinus stenting.MethodsWe retrospectively reviewed a prospectively maintained database spanning December 2011 to May 2015 of all patients with idiopathic intracranial hypertension who were screened for possible venous sinus stenting, including only patients who received a stent, noting symptomatic improvements, changes in opening lumbar puncture pressure, demographic characteristics, and any subsequent intervention after stent placement. Fisher's exact test and logistic regression were used to test each of seven potential predictors for retreatment.ResultsThere were eight revisions in 31 patients (25.8%). Among Caucasians, 8.0% required a revision compared with 100% of African-Americans (p<0.001). The c-index for race was 0.857. Body mass index (BMI) was also a significant predictor of revision (p=0.031): among class III obese patients the revision rate was 46.2% compared with 16.7% among class I and II obese patients and 0% among overweight to normal weight patients.ConclusionsBMI was a significant predictor of revision, suggesting that higher BMI may have a higher risk of revision. The small number of African-Americans in the study makes interpretation of the practical significance of the revision rate in these patients uncertain. None of the other studied factors was statistically significant.
Mechanical thrombectomy in patients with M1 occlusion and NIHSS score ≤5: a single-centre experience
Authors: Bhogal P , Bücke P , Ganslandt O , Bäzner H , Henkes H , Pérez M Aguilar 
Published: December 2016

BackgroundThe recent success of several mechanical thrombectomy trials has resulted in a significant change in management for patients presenting with stroke. However, it is still unclear how to manage patients that present with stroke and low National Institutes of Health Stroke Scale (NIHSS) ≤5. We sought to review our experience of mechanical thrombectomy in patients with low NIHSS and confirmed M1 occlusion.MethodsWe retrospectively analysed our prospectively maintained database of all patients undergoing mechanical thrombectomy between January 2008 and August 2016. We identified 41 patients with confirmed M1 occlusion and low NIHSS (≤5) on admission to our hospital. We collected demographic, radiological, procedural and outcome data.ResultsThe mean age of patients was 72±14, with 20 male patients. Associated medical conditions were common with hypertension seen in ∼80%. Just over 50% presented with NIHSS 4 or 5. The average ASPECTS score on admission was 8.8 (range 6–10), and the average clot length 10 mm. Angiographically Thrombolysis in Cerebral Infarction (TICI) ≥2b was obtained in 87.8% of patients. 7 patients had haemorrhage on follow-up, 2 of which were symptomatic. Of 40 patients with 90-day follow-up, 75% had modified Rankin Scale (mRS) score 0–2. There were 3 deaths at 90 days.ConclusionsMechanical thrombectomy in patients with low NIHSS and proximal large vessel occlusion is technically possible and carries a high degree of success with good safety profile. Patients with low NIHSS and confirmed occlusion should be considered for mechanical thrombectomy.
How to share the process of graduate advising
Authors: Wagner H.H. , Boyd C. , Napper R. 
Published: December 2016

This paper starts a two-part series on graduate advising that integrates concepts from adult learning, leadership, and psychology into a conceptual framework for graduate advising. A companion paper provides guidance on how to communicate effectively in graduate advising. Here, we present concepts and tools that enable advisors and graduate students to collaborate effectively and share the responsibility for the student’s learning. We specifically discuss (1) how to promote learning about learning to help students make sense of their experience and identify their supervision needs; (2) how to clarify roles and address conflicts of interest between different roles; and (3) how to establish an effective, learning-centered working relationship. By making the advising process explicit, using the concepts and worksheets presented here, advisors will contribute to the training of the next generation of graduate advisors.
Caracóis emplumados e Tlaloc na Mesoamérica pré-hispânica: abordagem comparativa com o noroeste amazônico
Authors: Karadimas Dimitri 
Published: December 2016

Os trompetes rituais do noroeste amazônico, quando tocados no momento da iniciação, fazem morrer os adolescentes, fazendo nascer homens adultos. A encenação ritual busca na metamorfose dos insetos uma analogia da troca de pele social a que os iniciados serão sujeitados. Um dos trompetes é construído à imagem da figura da crisálida de borboletas. Tidos como larvas, os adolescentes são “parasitados” pelos homens adultos para que eles os tornem guerreiros, fazendo com que eles se identifiquem às vespas que infestam esses locais de transformação. Ao retomar esses desenlaces rituais contemporâneos e as imagens que os acompanham, este artigo propõe-se analisar o caracol feito em uma concha marinha na Mesoamérica pré-hispânica, um artefato presente nos baixos relevos dos templos de Teotihuacán, e que aparece ligado tanto a Quetzalcoatl como a Tlaloc, o deus da chuva e das tempestades. Ao mostrar que as civilizações desta área cultural têm recursos às mesmas imagens que no noroeste amazônico, é possível realizar uma análise de várias de suas figuras que permanecem enigmáticas até o presente para mostrar que a mesma referência ao parasitismo esteve aí presente.
eHealth Spare Parts as a Service: Modular eHealth Solutions and Medical Device Reform
Authors: Purtova Nadezhda 
Published: December 2016

Abstract
eHealth Platform as a Service (‘PaaS’) is an innovative way to build mHealth apps out of cloud-based generic components. Having examined the current and future regimes of safety and performance, this article concludes that the ‘selling features’ of the PaaS (outsourced creation and maintenance of cloud-based parts for easy mHealth-building) undermine legal compliance, and the reform will not change this significantly. Although no safety and performance requirements apply yet to consumer eHealth, the medical apps are regulated. Their manufacturers must ensure the final apps are safe, while not being in control of the parts composing the apps. Generic components not meant for a specific medical device and their providers are not subject to safety and performance requirements. Market will likely push PaaS providers to offer mHealth manufacturers tools to ensure and control safety and performance when medical apps are concerned. I foresee no such incentives for consumer mHealth.
Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation
Authors: Gluckman Eliane , Cappelli Barbara , Bernaudin Francoise , Labopin Myriam , Volt Fernanda , Carreras Jeanette , Pinto Simões Belinda , Ferster Alina , Dupont Sophie , de la Fuente Josu , Dalle Jean-Hugues , Zecca Marco , Walters Mark C. , Krishnamurti Lakshmanan , Bhatia Monica , Leung Kathryn , Yanik Gregory , Kurtzberg Joanne , Dhedin Nathalie , Kuentz Mathieu , Michel Gerard , Apperley Jane , Lutz Patrick , Neven Bénédicte , Bertrand Yves , Vannier Jean Pierre , Ayas Mouhab , Cavazzana Marina , Matthes-Martin Susanne , Rocha Vanderson , Elayoubi Hanadi , Kenzey Chantal , Bader Peter , Locatelli Franco , Ruggeri Annalisa , Eapen Mary 
Published: December 2016

Key PointsHLA-identical sibling transplantation for SCD offers excellent long-term survival. Mortality risk is higher for older patients; event-free survival has improved in patients transplanted after 2006.
Vitamin levels in adults with ADHD
Authors: Landaas Elisabeth Toverud , Aarsland Tore Ivar Malmei , Ulvik Arve , Halmøy Anne , Ueland Per Magne , Haavik Jan 
Published: December 2016

BackgroundMicronutrients containing vitamins are reported to reduce symptom levels in persons with attention-deficit hyperactivity disorder (ADHD), but data on vitamin levels in ADHD are sparse.AimsTo examine the relationship between vitamin concentrations, ADHD diagnosis and psychiatric symptoms in young adult ADHD patients and controls.MethodEight vitamins and the nicotine metabolite cotinine were analysed in serum samples from 133 ADHD patients and 131 controls aged between 18 and 40, who also reported ADHD symptoms and comorbid conditions.ResultsLower concentrations of vitamins B2, B6 and B9 were associated with the ADHD diagnosis, and B2 and B6 also with symptom severity. Smokers had lower levels of vitamins B2 and B9.ConclusionsADHD patients were overrepresented in the group with low levels of some vitamins, possibly indicative of inadequate dietary intake of these micronutrients in a subgroup of patients. It is important to identify these patients in dietary intervention trials of ADHD.
Endoluminal thermal ablation of the great saphenous vein (GSV) insufficiency
Authors: Zollmann C. , Zollmann P. , Veltman J. , Gräser A. , Berger I. , Rabe E. , Sporbert F. 
Published: December 2016

SummaryTo evaluate and compare the fiveyear outcome after treatment of a varicose GSV by endovenous thermal laser ablation (EVLA) and radiofrequency ablation (RFA).In this non-randomized, prospective study, patients treated in 2007 and 2008 for complete varicosis of the GSV (CEAP: C2–C6) were divided according to the treatment technique used into three groups: RFA (VNUS ClosureFast™), EVLA 980 nm (ELVeS 980™) and EVLA 1470 nm (ELVeS 1470™). Ultrasound-guided follow-up consultations were conducted 3 days, 3 months, 1 year and 5 years after treatment.589 patients with 643 GSVs (223 RFA, 185 EVLA 980, 235 EVLA 1470) were treated under tumescent local anaesthesia. No major complications occurred and minor complications were rare (4.7–12.2 %, p=0.135).66 % (RFA), 15 % (EVLA 980) and 32 % (EVLA 1470) of the patients were pain-free without post-operative analgesics. After 5 years, 86 % (RFA), 90 % (EVLA 980) and 93 % (EVLA 1470) of the veins were occluded (p=0.096). Ultrasound imaging revealed reflux in treated GSVs in 5–8 % of cases (p=0.73). A second ablation of the previously treated GSV was required in 5 % (RFA), 2 % (EVLA 980) and 2 % (EVLA 1470) of the patients (p=0.28).Endoluminal thermal ablation is an easy, safe and well tolerated method for the treatment of varicosis. Radiofrequency ablation is less painful than EVLA. RFA and EVLA 1470 are equally effective for vein closure.
CHIVA treatment of saphenous vein insufficiency with aneurysm of the great saphenous vein in von Willebrand’s disease
Authors: Mendoza E. 
Published: December 2016

SummaryIn patients with an increased tendency to bleeding and severe varicose veins, even the minimally invasive venous procedure CHIVA requires careful planning and risk assessment. CHIVA treatment is reported in a 67-year-old female patient with aneurysm of the great saphenous vein at the saphenofemoral junction, reflux above and below the knee (Hach III), skin changes (C4a) and von Willebrand’s disease. Radiofrequency was used over a 13 cm segment in the proximal great saphenous vein. The result shows a reduction in the diameter of the great saphenous vein at the thigh from 8.2 to 5.4 mm and an absence of reflux and absence of clinic. Even in patients with severe findings, a minor procedure can achieve a good clinical result with low risk.
Mapping the distribution of Anopheles funestus across Benin highlights a sharp contrast of susceptibility to insecticides and infection rate to Plasmodium between southern and northern populations
Authors: Djouaka Rousseau , Akoton Romaric , Tchigossou Genevieve M. , Atoyebi Seun M. , Irving Helen , Kusimo Michael O. , Djegbe Innocent , Riveron Jacob M. , Tossou Eric , Yessoufou Akadiri , Wondji Charles S. 
Published: December 2016

Background. Malaria remains an important public health issue in Benin, with Anopheles gambiae s.l. and Anopheles funestus s.s being the predominant vectors. This study was designed to generate information on An. funestus distribution, molecular speciation, Plasmodium infection rate and insecticide susceptibility status across Benin. Methods. Mosquito samples were collected from December 2014 to January 2016 in 46 localities in Benin. These samples were mapped and An. funestus collected were speciated to the molecular level. Plasmodium infection rate was determined using a Taqman assay and susceptibility to insecticides was assessed using the WHO guidelines. The genotyping of the L119F- Gste2 mutation was also carried out. Results. An. funestus was found in 8 out of the 46 localities surveyed with a high presence in Tanongou (wet Sudanese ecological zone), Kpome, Doukonta and Pahou (sub-equatorial ecological zone). Molecular identifications revealed that only An. funestus s.s was present in southern Benin, whereas in Tanongou (northern Benin) An. funestus s.s. and An. leesoni were found in sympatry at proportions of 77.7% and 22.3% respectively. Plasmodium infection rate of An. funestus was higher in southern Benin at a range of 13 to 18% compared to 5.6% recorded in Tanongou. High DDT (8±0.5%) and permethrin (11±0.5%) resistance were observed in Doukonta, Kpome and Pahou, contrasting with relatively low resistance profiles: mortality-DDT=90±3.18% and mortality-permethrin=100% in Tanongou. Genotyping analysis revealed high frequency of the resistant 119F allele in the South (Kpome and Doukonta) compared to the North (Tanongou). Discussion and Conclusion. The high presence of An. funestus in the South compared to the North could be due to favorable environmental and climatic conditions found in both regions. A significant Plasmodium infection rate was recorded across the country. A high resistance profile was recorded in the southern Benin; this raises the need for further investigations on resistance selection factors.
The use of rats and mice as animal models inex vivobone growth and development studies
Authors: Abubakar A. A. , Noordin M. M. , Azmi T. I. , Kaka U. , Loqman M. Y. 
Published: December 2016

In vivo animal experimentation has been one of the cornerstones of biological and biomedical research, particularly in the field of clinical medicine and pharmaceuticals. The conventional in vivo model system is invariably associated with high production costs and strict ethical considerations. These limitations led to the evolution of an ex vivo model system which partially or completely surmounted some of the constraints faced in an in vivo model system. The ex vivo rodent bone culture system has been used to elucidate the understanding of skeletal physiology and pathophysiology for more than 90 years. This review attempts to provide a brief summary of the historical evolution of the rodent bone culture system with emphasis on the strengths and limitations of the model. It encompasses the frequency of use of rats and mice for ex vivo bone studies, nutritional requirements in ex vivo bone growth and emerging developments and technologies. This compilation of information could assist researchers in the field of regenerative medicine and bone tissue engineering towards a better understanding of skeletal growth and development for application in general clinical medicine.Cite this article: A. A. Abubakar, M. M. Noordin, T. I. Azmi, U. Kaka, M. Y. Loqman. The use of rats and mice as animal models in ex vivo bone growth and development studies. Bone Joint Res 2016;5:610–618. DOI: 10.1302/2046-3758.512.BJR-2016-0102.R2.
Progress toward resistance mechanism to epidermal growth factor receptor tyrosine kinase inhibitor
Authors: Zhang Lingling , Zhang Xiaoxue , Zhao Liang 
Published: December 2016

AbstractThe EGFR signaling pathway plays an important role in the occurrence and development of many malignant tumors. It has become a hot spot in the treatment of advanced cancer. At present, the small molecule epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has been shown to advanced non-small-cell lung cancer (NSCLC), has a marked drug resistance or has developed one. The EGFR signaling pathway regulates a variety of cellular functions, and its drug resistance may be related to a number of signal transduction pathways, including drug resistance mutations, structural activation, downstream signaling pathway activation and VEGF expression changes, and so on. In this paper, we review the production mechanism of EGFR-TKI drug resistance.
Effect of miRNAs in lung cancer suppression and oncogenesis
Authors: Zhang Suning , Liu Zongang 
Published: December 2016

AbstractMicroRNA (miRNAs) is a group of small non-coding RNAs. It is involved in multiple cellular processes including proliferation, development, metabolism, differentiation and apoptosis; many of which are linked to several pathological conditions, including cancer. Lung cancer is one of the leading causes of mortality in the world: in 2008 for example, there were 163,000 deaths as a result of lung cancer. Despite technologies emerging which provide the potential for novel targeted therapies and improved early diagnoses, the overall rate of five-year survival still remains at only 15%. One reason for this disappointing statistic is related to the presentation of the disease, and specifically a lack of markers for early detection. Notably, the expression of some miRNAs has been reported to be involved in the diagnosis, classification and even prognosis of lung cancer. Tumorsuppressive and oncogenic miRNAs were found in lung carcinogenesis and the biological functions of these miRNAs have been validated in transplantable lung cancer models and human paired normal-malignant lung tissue banks. Some of these tumor-suppressive and oncogenic miRNAs related to lung cancer will be reviewed here. This article will focus on emphasing miRNAs effectiveness as a biomarker in lung carcinogenesis and candidate pharmacology. Furthermore, how these findings improve our understanding of lung cancer biology and therapy will also be discussed.
Preconditioning Techniques Based on the Birkhoff–von Neumann Decomposition
Authors: Benzi Michele , Uçar Bora 
Published: December 2016

Abstract
We introduce a class of preconditioners for general sparse matrices based
on the Birkhoff–von Neumann decomposition of doubly stochastic matrices.
These preconditioners are aimed primarily at solving challenging linear
systems with highly unstructured and indefinite coefficient matrices.
We present some theoretical results and numerical experiments on
linear systems from a variety of applications.
Schottky groups acting on homogeneous rational manifolds
Authors: Miebach Christian , Oeljeklaus Karl 
Published: December 2016

Abstract
We systematically study Schottky group actions on homogeneous rational
manifolds and find two new families besides those given by Nori’s well-known
construction. This yields new examples of non-Kähler compact complex manifolds
having free fundamental groups. We then investigate their analytic and geometric
invariants such as the Kodaira and algebraic dimension, the Picard group and
the deformation theory, thus extending results due to Lárusson and to Seade
and Verjovsky. As a byproduct, we see that the Schottky construction allows to
recover examples of equivariant compactifications of

SL
⁢

(
2
,
ℂ
)

/
Γ

{{\rm{SL}}(2,\mathbb{C})/\Gamma}

for Γ a discrete free loxodromic subgroup
of

SL
⁢

(
2
,
ℂ
)

{{\rm{SL}}(2,\mathbb{C})}

, previously obtained by A. Guillot.
RF Behavior and Launcher Design for a Fast Frequency Step-tunable 236 GHz Gyrotron for DEMO
Authors: Kalaria P. C. , Avramidis K. A. , Franck J. , Gantenbein G. , Illy S. , Jin J. , Pagonakis I. Gr. , Thumm M. , Jelonnek J. 
Published: December 2016

AbstractAs part of the EUROfusion project, the conceptual design of a 1 MW 236 GHz hollow-cavity gyrotron is ongoing at IHM, KIT for a DEMOnstration Power Plant (DEMO), along with a 2 MW coaxial-cavity design concept. Fast frequency-tunable gyrotrons (tuning within a few seconds) are recommended for plasma stabilization using a non-steerable antenna. In this work, the mode-selection approach for such a frequency-tunable gyrotron is presented and suitable operating modes for fast frequency tunability are suggested. Magnetic field tuning has been studied as an effective technique to tune the gyrotron operating frequency. The step-tunability of the 236 GHz gyrotron within the frequency range of ±10 GHz in steps of 2–3 GHz is demonstrated in numerical simulations. A hybrid-type Quasi-Optical Launcher (QOL) has been designed for a step-frequency tunable gyrotron with sufficiently high Fundamental Gaussian Mode Content (FGMC).
Certain results concerning operators on a Lie algebra and double index sequences
Authors: Khan Subuhi , Ali Mahvish 
Published: December 2016

Abstract
In this paper, a result for double index sequences is established by using a quadratic combination of four operators defined on a Lie algebra of endomorphisms of a vector space.
This result is used to give new proofs of some properties of the Bessel and Tricomi functions of two indices. Further, this result is extended for multi-index sequences.
On a boundary value problem on an infinite interval for nonlinear functional differential equations
Authors: Kiguradze Ivan , Sokhadze Zaza 
Published: December 2016

Abstract
Sufficient conditions are found for the solvability of the following boundary value problem:

u

(
n
)

(
t
)

=
f

(
u
)

(
t
)

,

u

(

i
-
1

)

(
0
)

=

φ
i

(

u

(

n
-
1

)

(
0
)

)

(
i
=
1
,
…
,
n
-
1
)

,

lim inf

t
→

+
∞

|

u

(

n
-
2

)

(
t
)

|
<
+
∞
,

u^{(n)}(t)=f(u)(t),\qquad u^{(i-1)}(0)=\varphi_{i}(u^{(n-1)}(0))\quad(i=1,%
\dots,n-1),\qquad\liminf_{t\to+\infty}\lvert u^{(n-2)}(t)|<+\infty,

where

f
:

C

n
-
1

⁢

(

ℝ
+

)

→

L
loc

⁢

(

ℝ
+

)

{f\colon C^{n-1}(\mathbb{R}_{+})\to L_{\mathrm{loc}}(\mathbb{R}_{+})}

is a continuous Volterra operator, and

φ
i

:

ℝ
→
ℝ

{\varphi_{i}\colon\mathbb{R}\to\mathbb{R}}

(

i
=

1
,
…
,
n

{i=1,\dots,n}

) are continuous functions.
The normality criteria for families of entire algebroid functions
Authors: Chai Fujie , Gao Zongsheng 
Published: December 2016

Abstract
In this paper, we first prove that the normality
of a family of k-valued algebroid functions is not equivalent to the normality of the family of the coefficient functions in general.
Moreover, by combining the Valiron characteristic function of algebroid functions and the Schottky theorem of holomorphic functions, we investigate the growth relationship between the maximum modulus of an algebroid function and the maximum modulus of its coefficient functions.
On this basis, we prove several normality criteria which do not need to restrict the quantity of branch points and contain a very interesting Montel-type normality criterion for entire algebroid function families.
Impulsive differential inclusions via variational method
Authors: Benchohra Mouffak , Nieto Juan J. , Ouahab Abdelghani 
Published: December 2016

Abstract
In this paper, we establish several results about the existence of second-order impulsive differential inclusion with periodic conditions. By using critical point theory, several new existence results are obtained. We also provide an example in order to illustrate the main abstract results of this paper.