bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between IRF6 and 8q24 polymorphisms and nonsyndromic cleft lip with or without cleft palate: Systematic review and meta‐analysis
Authors: Wattanawong Kachin , Rattanasiri Sasivimol , McEvoy Mark , Attia John , Thakkinstian Ammarin 
Published: August 2016

BackgroundWe conducted a systematic review and meta‐analysis of interferon regulatory factor 6 and 8q24 polymorphisms with nonsyndromic cleft lip with/without cleft palate (NSCL/P).MethodsData extraction was independently performed by two reviewers. Genotypic effects of four polymorphisms from 31 studies were pooled separately by ethnicity using a mixed‐effect logit model with accounting for heterogeneity.ResultsFor rs2235371, AA and GA carried, respectively, 51% (95% confidence interval [CI], 37%–61%) and 42% (95% CI, 32%–50%) lower risks of NSCL/P than GG genotypes in Asians, but these genotypes were not significant in Caucasians. For rs2013162, only AA was significant, that is, carried 0.65 (95% CI, 0.52–0.82) times lower odds than CC in Caucasians but not for Asians. For rs642961, AA and GA genotypes, respectively, carried 2.47 (95% CI, 1.41–4.35) and 1.40 (95% CI, 1.12–1.75) times higher odds in Asian, and 2.03 (95% CI, 1.52–2.71) and 1.58 (95% CI, 1.37–1.82) times higher odds in Caucasians compare with GG genotypes. For rs987525, AA and CA genotypes carried 2.27 (95% CI, 1.43–3.60) and 1.34 (95% CI, 1.02–1.77) times higher odds in Asian, and 5.25 (95% CI, 3.98–6.91) and 2.13 (95% CI–1.82, 2.49) times higher odds in Caucasians, and 1.42 (95% CI, 1.10–1.82) and 1.28 (95% CI, 1.09–1.50) times higher odds in mixed ethnicities compared with CC genotypes. These variant effects remained significant based on applying Bonferroni corrected‐thresholds, except in the mixed ethnicity.ConclusionWe show robust variant effects in NSCL/P. Considering them with other genes and risk factors might be useful to improve prediction of NSCL/P occurrence. Birth Defects Research (Part A) 106:773–788, 2016. © 2016 The Authors Birth Defects Research Part A: Clinical and Molecular Teratology Published by Wiley Periodicals, Inc.
Birth defects and neonatal morbidity caused by teratogen exposure after the embryonic period
Authors: Scheuerle Angela E. , Aylsworth Arthur S. 
Published: August 2016

BackgroundPharmaceutical pregnancy exposure registries seek to evaluate temporal associations between drug exposures and adverse outcomes, particularly congenital anomalies. These registries record observed associations that may or may not be causally‐related to the exposure. Most major congenital malformations (i.e., structural birth defects) result from abnormal development during embryogenesis. A standardized catalog of defects of concern (colloquially the “BPA Codes”) is used both in public health surveillance programs and pregnancy exposure registries. There are, however, some anomalies that cause significant morbidity and mortality for which isolated second or third trimester exposures may be pathogenically significant. There currently exists no standardized list of defects for which exposure limited to the fetal period may be problematic.MethodsThe six‐digit‐code list was used to determine anomalies that might result from medication exposures limited to the fetal period.ResultsDefects with documented first trimester pathogenesis (e.g., anencephaly, heterotaxy) were eliminated from consideration, as were chromosomal and single gene disorders (e.g., trisomy 21, achondroplasia). The remaining defects include the following: (1) those that are known to or could reasonably originate or manifest after the embryonic period (e.g., porencephaly, cataracts); (2) those for which pathogenesis is unclear or variable enough that exposure at any gestational age might be considered relevant (e.g., club foot, microcephaly); and (3) those that include some component of abnormal growth (e.g., hemihyperplasia). “Unspecified” defects (e.g., “abnormality of the leg”) were included by default because there is insufficient information to assume first trimester embryogenesis.ConclusionThe final result is a list of major and minor anomalies in 11 organ system categories that may be caused by teratogen exposure during the fetal period. Birth Defects Research (Part A) 106:935–939, 2016. © 2016 Wiley Periodicals, Inc.
Review of bioanalytical assays for the quantitation of various HDAC inhibitors such as vorinostat, belinostat, panobinostat, romidepsin and chidamine
Authors: Suresh P.S. , Devaraj V.C. , Srinivas Nuggehally R. , Mullangi Ramesh 
Published: August 2016

AbstractHistone deacetylase inhibitors (HDAC inhibitors) are used to treat malignancies such as cutaneous T cell lymphoma and peripheral T cell lymphoma. Only four drugs are approved by the US Food and Drug Administration, namely vorinostat, romidepsin, panobinostat and belinostat, while chidamide has been approved in China. There are a number of bioanalytical methods reported for the measurement of HDAC inhibitors in clinical (human plasma and serum) and preclinical (mouse plasma, rat plasma, urine and tissue homogenates, etc.) studies. This review covers various HDAC inhibitors such as vorinostat, romidepsin, panobinostat, belinostat and chidamide. In addition to providing a comprehensive review of the available methods for the above mentioned HDAC inhibitors, it also provides case studies with perspectives for chosen drugs. Based on the review, it is concluded that the published methodologies using either HPLC or LC–MS/MS are well suited for the quantification of HDAC inhibitors in various biological fluids to delineate pharmacokinetic data.
Safety and efficacy of coil embolization of the septal perforator for septal ablation in patients with hypertrophic obstructive cardiomyopathy
Authors: Guerrero Israel , Dhoble Abhijeet , Fasulo Mark , Denktas Ali E. , Sami Shehzad , Choi Sangbum , Balan Prakash , Arain Salman A. , Smalling Richard W. 
Published: August 2016

ObjectiveThe objective of this study was to evaluate safety, efficacy, and durability of coil embolization of the major septal perforator of the left anterior descending coronary artery in patients with hypertrophic obstructive cardiomyopathy (HOCM).BackgroundThe long‐term effect of coil embolization therapy in HOCM patients is not well defined.MethodsWe evaluated 24 symptomatic HOCM patients in a single center who underwent coil embolization of the septal perforator artery(ies).ResultsTwenty‐four patients on optimal medical therapy presented with NYHA functional class III (75%) or IV (25%) underwent the procedure. The procedure was successful in 22 patients, with significant reduction in left ventricular outflow tract (LVOT) gradient. The functional class significantly improved to class I (54.2%) or II (41.7%) (P < = 0.01). The LVOT gradient was significantly lower during follow up echocardiography (21.3 ± 19 vs. 81.3 ± 41 mm Hg; P < = 0.01). Interventricular septal thickness decreased over time (16.3 ± 3 vs. 18.5 ± 2 mm, P< = 0.01). The procedure was aborted in one of the patients after the third coil prolapsed from the septal perforator in to the left anterior descending artery. The coil was effectively snared out. Three patients required additional coil placement in the second major septal perforator. New permanent pacemaker placement was required in one patient. However, three patients underwent ICD implantation at follow up due to ventricular arrhythmias.ConclusionsThe results of this study suggest that the use of coil embolization for septal ablation is safe, effective, and durable in patients with symptomatic HOCM. © 2016 Wiley Periodicals, Inc.
ChemInform Abstract: The Planar CoB18‐ Cluster as a Motif for Metallo‐Borophenes.
Authors: Li Wan‐Lu , Jian Tian , Chen Xin , Chen Teng‐Teng , Lopez Gary V. , Li Jun , Wang Lai‐Sheng 
Published: August 2016

AbstractThe title cluster is produced by laser vaporization of a boron/cobalt composite target and characterized by PES and quantum chemical CCSD(T) and DFT calculations.
ChemInform Abstract: High Temperature Crystallographic and Thermodynamic Investigations on Synthetic Calzirtite (Ca2Zr5Ti2O16).
Authors: Jafar Mohsin , Phapale Suhas B. , Nagabhusan Achary S. , Mishra Ratikanta , Tyagi Avesh K. 
Published: August 2016

AbstractThe title material is characterized by variable temperature powder XRD and high temperature solution calorimetric measurements.
ChemInform Abstract: Intriguing Luminescence Properties of (Ba, Sr)3Si6O9N4: Eu2+ Phosphors via Modifying Synthesis Method and Cation Substitution.
Authors: Yin Liang‐Jun , et al.  
Published: August 2016

AbstractA series of green to blue emitting phosphors of nominal composition (Ba, Sr)2.85Si6O9N4:0.15Eu 2+ is prepared by solid state reaction of BaCO3, SrCO3, Eu2O3, Si3N4, and SiO2 (high‐energy ball milling, annealing under N2 for 4 h at 1200 °C).
ChemInform Abstract: High Thermoelectric Performance of In‐Doped Cu2SnSe3 Prepared by Fast Combustion Synthesis.
Authors: Li Yuyang , Liu Guanghua , Li Jiangtao , Chen Kexin , Li Laifeng , Han Yemao , Zhou Min , Xia Mingjun , Jiang Xingxing , Lin Zheshuai 
Published: August 2016

AbstractBulk Cu2Sn1‐xInxSe3 (x = 0—0.2) samples are prepared by high‐pressure combustion synthesis (HPCS) of stoichiometric amounts of the elements under 2 MPa Ar in a quartz tube.
ChemInform Abstract: Environmentally Friendly BaxSr2‐xTiFeO6 Double Perovskite with Enhanced Thermopower for High Temperature Thermoelectric Power Generation.
Authors: Roy Pinku , Waghmare Vikram , Maiti Tanmoy 
Published: August 2016

AbstractThe title compounds with x = 0, 0.1, 0.15, and 0.25 are prepared by solid state reaction of SrCO3, BaCO3, Fe2O3, and TiO2 (1473 K, 10 h, followed by sintering at 1623 K for 10 h).
ChemInform Abstract: Trace H2O2‐Assisted High‐Capacity Tungsten Oxide Electrochromic Batteries with Ultrafast Charging in Seconds.
Authors: Zhao Jinxiong , Tian Yuyu , Wang Zhen , Cong Shan , Zhou Di , Zhang Qingzhu , Yang Mei , Zhang Weikun , Geng Fengxia , Zhao Zhigang 
Published: August 2016

AbstractW18O49 nanowires are grown on an FTO‐coated glass substrate by hydrothermal treatment of a WCl6 in EtOH solution (180 °C, 12 h) followed by annealing in Ar at 200 °C.
ChemInform Abstract: Cu1.5Mn1.5O4 Spinel: A Novel Anode Material for Lithium‐Ion Batteries.
Authors: Quan Jingbin , Mei Lin , Ma Zheng , Huang Jichun , Li Decheng 
Published: August 2016

AbstractCu1.5Mn1.5O4 is prepared by spray drying of an aqueous solution of Cu(OAc)2, Mn(OAc)2, and citric acid with an outlet temperature of 185 °C followed by pre‐sintering in air (300 °C, 3 h).
ChemInform Abstract: Preparation, Characterization and Photocatalytic Studies of Cu2+, Sn2+ and N3‐ Substituted K5Sb5P2O20.
Authors: Reddy Ch. Sudhakar , Sreenu K. , Reddy J. R. , Padmasri A. Hari , Gundeboina Ravi , Vithal M. 
Published: August 2016

AbstractK5Sb5P2O20 (I) is prepared by solid state reaction of stoichiometric amounts of KNO3, Sb2O3, and (NH4)2HPO4 (1.
ChemInform Abstract: Indolinol‐Catalyzed Asymmetric Michael Reaction of Aldehydes to Nitroalkenes in Brine.
Authors: Hu Xin , Wei Yi‐Fei , Wu Nan , Jiang Zhiguo , Liu Can , Luo Ren‐Shi 
Published: August 2016

AbstractThe asymmetric Michael reaction of nitroalkenes (I) with aldehydes (II) proceeds with good to high enantio‐ and diastereoselectivity, whilst the reaction of nitroalkene (VI) gives rise to a mixture of syn/anti‐diastereomers with 45:55 ratio.
ChemInform Abstract: New Metal Complexes Supported on Fe3O4 Magnetic Nanoparticles as Recoverable Catalysts for Selective Oxidation of Sulfides to Sulfoxides.
Authors: Hajjami Maryam , Kolivand Somaye 
Published: August 2016

AbstractThe Zr‐based complex catalysts can be easily recovered ten times and the analogous Cu‐based complex seven times without noticeable deterioration in catalytic activity.
ChemInform Abstract: Supported Gold Nanoparticles Catalyzed cis‐Selective Semihydrogenation of Alkynes Using Ammonium Formate as the Reductant.
Authors: Liang Shengzong , Hammond Gerald B. , Xu Bo 
Published: August 2016

AbstractAn efficient procedure is developed for the gold‐catalyzed semihydrogenation of alkynes.
ChemInform Abstract: Photocatalytic/Cu‐Promoted C—H Activations: Visible‐Light‐Induced ortho‐Selective Perfluoroalkylation of Benzamides.
Authors: Chen Xiang , Tan Ze , Gui Qingwen , Hu Liang , Liu Jidan , Wu Jing , Wang Guangwei 
Published: August 2016

AbstractN‐8‐Quinolyl directed highly selective ortho‐perfluoroalkylation of benzamide (I) and (IV) is developed.
ChemInform Abstract: Dysprosium(III)‐Catalyzed Ring‐Opening of meso‐Epoxides: Desymmetrization by Remote Stereocontrol in a Thiolysis/Elimination Sequence.
Authors: Yao Lu , Zhu Qiao , Wei Liang , Wang Zuo‐Fei , Wang Chun‐Jiang 
Published: August 2016

AbstractThis unprecedented asymmetric desymmetrization of meso‐epoxides with mercaptobenzothiazoles is catalyzed by a chiral Dy(III)/N,N‐dioxide complex through a thiolysis/elimination sequence.
ChemInform Abstract: One‐Step Construction of Saturated Six‐Membered Rings Directly Using Calcium Carbide as an Acetylene Source: Synthesis of 1,3,5‐Triaroylcyclohexanes.
Authors: Li Zheng , He Lili , Fu Rugang , Song Geyang , Song Wenli , Xie Demeng , Yang Jingya 
Published: August 2016

AbstractThe title cyclohexanes are efficiently prepared from various aromatic and heteroaromatic aldehydes without use of precious transition metal catalysts, and flammable and explosive gas.
ChemInform Abstract: One‐Pot, Enantioselective Synthesis of 2,3‐Dihydroazulen‐6(1H)‐one: A Concise Access to the Core Structure of Cephalotaxus Norditerpenes.
Authors: Yongsheng Zheng , Ghazvini Zadeh Ebrahim H. , Yuan Yu 
Published: August 2016

AbstractA series of chiral dihydroazulenones (III) is prepared by a three‐step procedure comprising a Michael reaction of aldehydes (I) with nitroalkenes (II), a reduction of the Michael adduct to alcohol, and an oxidative cyclization/ring expansion.
ChemInform Abstract: A Mild and Base‐Free Protocol for the Ruthenium‐Catalyzed Hydrogenation of Aliphatic and Aromatic Nitriles with Tridentate Phosphine Ligands.
Authors: Adam Rosa , Bheeter Charles Beromeo , Jackstell Ralf , Beller Matthias 
Published: August 2016

AbstractThe optimal catalyst combination RUC/TDP is evaluated and applied to various aliphatic and aromatic nitriles under conditions A), mostly at 50 °C.
ChemInform Abstract: A Convenient Palladium‐Catalyzed Reductive Carbonylation of Aryl Iodides with Dual Role of Formic Acid.
Authors: Qi Xinxin , Li Chong‐Liang , Wu Xiao‐Feng 
Published: August 2016

AbstractA palladium‐catalyzed reductive carbonylation of aryl iodides with formic acid as the formyl source is presented.
ChemInform Abstract: Supporting Ligand‐Assisted N‐Heterocyclic Carbene Palladium Complexes: Characterization, Computation, and Catalytic Activity in Suzuki—Miyaura Cross Coupling Between Aryl and Heteroaromatic Chlorides and Various Boronic Acids.
Authors: Shen An , Hu Yu‐Cai , Liu Ting‐Ting , Ni Chen , Luo Yong , Cao Yu‐Cai 
Published: August 2016

AbstractThis method uses catalyst loadings as low as 0.005 mol%.
ChemInform Abstract: Enantioselective Allylic Substitution of Morita—Baylis—Hillman Adducts Catalyzed by Chiral Bifunctional Ferrocenylphosphines.
Authors: Zhu Linglong , Hu Haiwen , Qi Liang , Zheng Yi , Zhong Weihui 
Published: August 2016

AbstractAir‐stable chiral ferrocenylphosphines are synthesized and utilized in the asymmetric allylic substitution of Morita—Baylis—Hillman adducts with phthalimide under mild reaction conditions.
ChemInform Abstract: Direct and Site‐Selective Pd(II)‐Catalyzed C‐7 Arylation of Indolines with Arylsilanes.
Authors: Luo Haiqing , Liu Haidong , Zhang Zhipeng , Xiao Yifan , Wang Sihui , Luo Xuzhong , Wang Kejun 
Published: August 2016

AbstractA wide range of substrates is applied under mild reaction conditions.
ChemInform Abstract: A General Route to Fluorinated 3,3‐Disubstituted 2‐Oxindoles via a Photoinduced Radical Cyclization of N‐Arylacrylamides under Catalyst‐Free Conditions.
Authors: An Yuanyuan , Li Yuewen , Wu Jie 
Published: August 2016

AbstractA catalyst‐free radical cyclization of N‐arylacrylamides with fluorinated alkyl iodides under ultraviolet radiation is presented for the first time.
ChemInform Abstract: Synthesis of Pyrazoles via Electrophilic Cyclization of Alkynes Containing Thiophene.
Authors: Cetin Adnan 
Published: August 2016

AbstractBut‐3‐yn‐2‐one and hydrazines yield α,β‐alkynic hydrazones which give the final products after a copper‐mediated electrophilic cyclization.
ChemInform Abstract: A Copper‐Catalyzed Cascade Reaction of O‐Bromoarylisothiocyanates with Isocyanides Leading to Benzo[d]imidazo[5,1‐b]thiazoles under Ligand‐Free Conditions.
Authors: Yan Kelu , Yang Daoshan , Wei Wei , Sun Pengfei , Lu Yunxiang , Wang Hua 
Published: August 2016

AbstractTitle compounds are obtained through an intermolecular [3 + 2] cycloaddition and intramolecular Ullmann‐type C—S bond formation from readily available o‐bromoarylisothiocyanates and isocyanides.
ChemInform Abstract: Highly Efficient Synthesis of Tetrasubstituted 2,3‐Dihydropyrans by Three‐Component “One‐Pot” Reaction.
Authors: Li Chao , Cai Liang‐Zhen , Liu Xiao‐Dong , Zhu Shi‐Zheng , Xing Chun‐Hui , Lu Long 
Published: August 2016

Abstractβ‐Keto perfluoroalkanesulfones react with aldehydes and vinyl ethers to produce dihydropyran products as cis‐ and trans‐diastereomeric mixtures.
ChemInform Abstract: Copper‐Catalyzed C5‐Regioselective C—H Sulfonylation of 8‐Aminoquinoline Amides with Aryl Sulfonyl Chlorides.
Authors: Li Jun‐Ming , Weng Jiang , Lu Gui , Chan Albert S. C. 
Published: August 2016

AbstractThe title method tolerates various substituents in both reaction partners.
ChemInform Abstract: Ce(SO4)2‐Catalyzed the Highly Diastereoselective Synthesis of Tetrahydroquinolines via an Imino Diels—Alder ABB′ Type Reaction and Their in vivo Toxicity and Imaging in Zebrafish Embryos.
Authors: Martinez Bonilla Carlos A. , Puerto Galvis Carlos E. , Vargas Mendez Leonor Y. , Kouznetsov Vladimir V. 
Published: August 2016

AbstractDerivative (IIIb) appears to be the most toxic sample among the tetrahydroquinoline library synthesized.
ChemInform Abstract: Synthesis of Novel 1H‐Imidazol[1,2‐a]indeno[2,1‐e]pyridine‐6(5H)‐ones Derivatives via a One‐Pot Four‐Component Condensation Reaction.
Authors: Mohammadi Ali A. , Taheri Salman , Amouzegar Ali 
Published: August 2016

AbstractThe title compounds are prepared by multicomponent condensation of ethylenediamine, ketene dithioacetal, aldehydes, and indandione using alum as catalyst in good to excellent yields under green reaction conditions.
ChemInform Abstract: A Facile Synthesis of 5‐Phenyl‐dibenzo[b,g][1,8]napthyridines.
Authors: Sampathkumar Natarajan , Murugesh Arumugam , Rajendran Subramaniam Parameswaran 
Published: August 2016

AbstractThe hitherto unknown title naphthyridines are prepared by Vilsmeier—Haack heterocyclization of 2‐phenylamino‐4‐phenylquinolines in good yield.
ChemInform Abstract: Simple and Efficient Synthesis of 2‐Oxo‐2H‐pyrido[1,2‐a]pyrimidin‐3(4H)‐ylidene Acetic Acid and Its Rearrangement in Presence of Acid Media.
Authors: Venugopal Sharulatha , Sundaram Sivakamasundari 
Published: August 2016

AbstractThe title pyrimidine derivatives are prepared by reaction of aminopyridines and aconic acid.
ChemInform Abstract: Tailor‐Made α‐Amino Acids in the Pharmaceutical Industry: Synthetic Approaches to (1R,2S)‐1‐Amino‐2‐vinylcyclopropane‐1‐carboxylic Acid (Vinyl‐ACCA)
Authors: Sato Tatsunori , Izawa Kunisuke , Acena Jose Luis , Liu Hong , Soloshonok Vadim A. 
Published: August 2016

AbstractReview: [68 refs.
Evaluation of Substituted 1,2,3‐Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism
Authors: Asquith Christopher R. M. , Konstantinova Lidia S. , Laitinen Tuomo , Meli Marina L. , Poso Antti , Rakitin Oleg A. , Hofmann‐Lehmann Regina , Hilton Stephen T. 
Published: August 2016

AbstractA diverse library of 5‐thieno‐, 5‐oxo‐, and 5‐imino‐1,2,3‐dithiazole derivatives was synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.
Gap junction proteins and the wiring (Rewiring) of neuronal circuits
Authors: Baker Michael W. , Macagno Eduardo R. 
Published: August 2016

ABSTRACTThe unique morphology and pattern of synaptic connections made by a neuron during development arise in part by an extended period of growth in which cell–cell interactions help to sculpt the arbor into its final shape, size, and participation in different synaptic networks. Recent experiments highlight a guiding role played by gap junction proteins in controlling this process. Ectopic and overexpression studies in invertebrates have revealed that the selective expression of distinct gap junction genes in neurons and glial cells is sufficient to establish selective new connections in the central nervous systems of the leech (Firme et al. [2012]: J Neurosci 32:14265–14270), the nematode (Rabinowitch et al. [2014]: Nat Commun 5:4442), and the fruit fly (Pézier et al., 2016: PLoS One 11:e0152211). We present here an overview of this work and suggest that gap junction proteins, in addition to their synaptic/communicative functions, have an instructive role as recognition and adhesion factors. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 575–586, 2017
Prediction of response to tapentadol in chronic low back pain
Authors: Reimer M. , Hüllemann P. , Hukauf M. , Keller T. , Binder A. , Gierthmühlen J. , Baron R. 
Published: August 2016

AbstractBackgroundMany chronic low back pain (cLBP) patients do not satisfactorily respond to treatment. The knowledge of responders and non‐responders before initiating treatment would improve decision making and reduce health care costs. The aims of this exploratory prediction study in cLBP patients treated with tapentadol were to identify predictors of treatment outcome based on baseline characteristics, to evaluate quality‐of‐life and functionality as alternative outcome parameters and to develop nomograms to calculate the individual probability of response.MethodsIn a retrospective analysis of an open‐label phase 3b trial, 46 baseline characteristics were included into statistical prediction modelling. One hundred and twenty‐one patients were followed up during the titration and treatment period and 67 patients were analysed who discontinued the trial.ResultsDemographic data were not relevant for response prediction. Nine baseline co‐variables were robust: painDETECT score, intensity of burning and painful attacks, SF36 Health Survey score (MCS, PCS), EuroQol‐5, Hospital Anxiety/Depression Scale. Gender had a minor influence. Alternative outcomes (quality‐of‐life, functionality) were more important for response prediction than conventional pain intensity measures. Neuropathic symptoms (high painDETECT score) had a positive predictive validity. Painful attacks and classical yellow flags (depression, anxiety) negatively influenced the treatment response. High depression scores, female gender and low burning predicted discontinuation during titration.ConclusionIn this exploratory study, predictive baseline characteristics have been identified that can be used to calculate the individual probability of tapentadol response in cLBP. The small sample size in relation to the number of initial variables is a limitation of this approach.SignificancePredictors for treatment response of tapentadol were identified in patients with chronic low back pain based on clinical pre‐treatment characteristics that can guide personalized treatment. Quality‐of‐life and functionality were the most relevant outcomes for response prediction.