bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomarker-Based Prediction of Ischemic Stroke in Patients With H-type Hypertension
Authors: Chen Ke , He Jianxun , Fu Lan , Song Xiaohua , Cao Ning , Yuan Hui 
Published: October 2024

Abstract

Hypertension combined with hyperhomocysteinemia significantly raises the risk of ischemic stroke. Our study aimed to develop and validate a biomarker-based prediction model for ischemic stroke in H-type hypertension patients. We retrospectively included 3,305 patients in the development cohort, and externally validated in 103 patients from another cohort. Logistic regression, LASSO regression, and best subset selection analysis were used to assess the contribution of variables to ischemic stroke, and models were derived using four machine learning algorithms. Area Under Curve (AUC), calibration plot and decision-curve analysis (DCA) respectively evaluated the discrimination and calibration of four models, then external validation and visualization of the best-performing model. There were 1,415 and 42 patients with ischemic stroke in the development and validation cohorts. The final model included 8 predictors: age, antihypertensive therapy, biomarkers (serum magnesium, serum potassium, proteinuria and hypersensitive C-reactive protein), and comorbidities (atrial fibrillation and hyperlipidemia). The optimal model, named A2BC ischemic stroke model, showed good discrimination and calibration ability for ischemic stroke with AUC of 0.91 and 0.87 in the internal and external validation cohorts. The A2BC ischemic stroke model had satisfactory predictive performances to assist clinicians in accurately identifying the risk of ischemic stroke for patients with H-type hypertension.
Efficacy of Venetoclax combined with Homoharringtonine and Cytarabine for Younger Adults with Newly Diagnosed AML
Authors: Song Bao-Quan , Liu Yin , Kong Xin , Pu Yan , Zhang Jian , Wu De-Pei , Qiu Hui-ying 
Published: October 2024

Abstract

Venetoclax (VEN) based induction therapy have shown a promising treatment for patients with acute myeloid leukemia (AML). However, the optimal VEN combination is urgently needed. We aimed to investigate the effective and tolerability of venetoclax combined with homoharringtonine plus cytarabine (VHA) regimen for newly diagnosed AML. We retrospectively analyzed the outcomes of 55 ND AML patients treated with VHA regimen. The overall response rate (ORR) was 92.7% (51/55, 95% CI 82%-98%). The composite complete remission (CRc) rate was 87.3% (48/55, 95% CI 76%-95). 44 (91.7%, 95% CI 67-90) of 48 patients who reached complete remission (CR) and measurable residual disease (MRD)-negative was attained in 85.4% of CRc patients (41/48, 95% CI72-94). ORR and CRc were 95% (19 of 20 patients)[95% CI 75%-100%] and 75% (15 of 20 patients) [95% CI 51%-91%] in patients with adverse risk. The most common grade 3-4 adverse events were febrile neutropenia (32.7%), pneumonia (16.3%) and sepsis (9.1%). Median overall survival (OS) was 26 months and event-free survival (EFS) was not reached. 1-year overall survival was 83%, 1-year event-free survival was 82%. These preliminary data suggest that the VHA regimen leads to a very high rate of CR and low toxicity. Especially for adverse risk patients, it provide an opportunity for allogeneic haematopoietic stem cell transplantation (allo-HSCT).
Strategies for Management of Posterior Deciduous and Young Permanent Teeth with Developmental Defects of Enamel - Systematic Review and Meta-analysis
Authors: Tedesco Tamara , Pascareli-Carlos Aline , Ribeiro Rayane , Souza Beatriz , Floriano Isabela , Diniz Michele , Bezerra Sávio , Silva Erika , Raggio Daniela , Novaes Tatiane 
Published: October 2024

Abstract

Objectives: To assess the management strategies for treating deciduous and young permanent teeth with Developmental defects of enamel (DDE) presenting post-eruptive breakdown or atypical cavitated carious lesions.
Methods: Electronic databases searches were conducted up to May 31, 2023, identifying clinical studies related to the treatment strategies for posterior deciduous or young permanent teeth with DDE in children up to 14 years old. Results: Sixteen studies were included: 12 focusing on molar incisor hypomineralization (MIH), 1 on hypomineralization, 1 on imperfect amelogenesis, and 2 incorporating different types of DDE. Esthetic Crowns, Metal Crowns, Composite Resin (CR), Glass Ionomer Cement (GIC), and Metal and CR Onlays were the most used restorative treatments. Only similar studies for MIH were found, and meta-analyses were conducted. Over a 24-month follow-up period, a proportion of success rate of 96% (95% CI 92%-100%) was identified. Subgroup analysis did not reveal a difference among the restorative treatments (p = 0.922).
Conclusion: Aesthetic and metal crowns, CR, and GIC can be used with high longevity. However, the certainty of evidence is low, and most studies exhibited a high risk of bias.PROSPERO database CRD42021204415
Superselective embolization of the segmental artery of a ruptured horseshoe kidney: a case report
Authors: Dimitrić Žarko , Petreš Andrej , Vojinov Saša , Jeremić Dimitrije , Lakić Tanja , Govedarica Srđan 
Published: October 2024

Abstract

Background:
The horseshoe kidney (HSK) is the most common upper urinary system congenital defect, and blunt force injury accounts for 19% of kidney injuries in people with preexisting renal diseases.
Case presentation:
A 73-year-old patient, who was involved in a road traffic accident, was admitted to the Emergency department. А computed tomography (CT) trauma scan revealed a ruptured horseshoe kidney after which superselective embolization was successfully performed.
Conclusions
Uncommon emergencies such as this present difficulty in selecting the appropriate treatment, with this case report contributing to a potential standardized approach for this kind of emergency.
Four months of treatment with anakinra combined with glucocorticoids for giant cell arteritis: a multicenter, randomized, double-blind, placebo-controlled trial
Authors: de Boysson Hubert , Ly Kim Heang , Geffray Loïk , Quemeneur Thomas , Liozon Eric , Bezanahary Holy , Gouellec Noémie Le , Audemard Alexandra , Dumont Anael , Deshayes Samuel , Boutemy Jonathan , Maigné Gwénola , Silva Nicolas Martin , Sultan Audrey , Mauff Brigitte Le , Petit Gauthier , Parienti Jean-Jacques , Aouba Achille 
Published: October 2024

Abstract

Background
Efficacy and tolerance of anakinra (ANK) in the treatment of giant cell arteritis (GCA) need to be assessed.
Methods
This phase 3 study (NCT02902731) was a prospective multicenter, randomized, double-blind, placebo-controlled trial conducted over a 52-week period. GCA patients were randomized 1:1. From inclusion to week 16 (W16), patients in the anakinra (ANK) group received a daily subcutaneous injection of 100 mg of anakinra, whereas patients in the other group received placebo (PBO). In both arms, glucocorticoid (GC) discontinuation was planned at week 52 (W52). The endpoints were the relapse rates at W16, W26, and W52 and the completion of GC tapering. Given the emergence of the SARS-CoV-2 pandemic, the study was stopped prematurely.
Results
Thirty patients with new GCA diagnoses from 5 centers were randomized as follows: 17 in the ANK group and 13 in the PBO group. During the first 16 weeks, the relapse rates were 12% (n = 2) and 23% (n = 3) in the ANK and PBO groups, respectively (p = 0.63). At week 26, 12 (40%) patients had relapsed: 8 (47%) in the ANK group and 4 (31%) in the PBO group (p = 0.47). At W52, the relapse rate (overall, 50%) did not differ between the ANK group (53%; 9/17 patients) and the PBO group (46%; 6/13 patients) (p = 1). Two patients in each group discontinued GCs (p = 0.87). Seven serious AEs were reported in five patients, including 4 in patients receiving ANK.
Conclusions
Although prematurely discontinued, this study does not support the use of 4 months of treatment with anakinra combined with GCs to reduce the risk of relapse or GC exposure.
Trial registration:
ClinicalTrials.gov NCT02902731
Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates
Authors: Naninck Thibaut , Detrille Alexandra , Huvelle Steve , Gils Marit J. van , Geara Tatiana , Pascal Quentin , Snitselaar Jonne , Bossevot Laetitia , Cavarelli Mariangela , Bosquet Nathalie , Relouzat Francis , Contreras Vanessa , Chapon Catherine , Caillé Fabien , Sanders Rogier , Grand Roger Le 
Published: October 2024

Abstract

The COVID-19 pandemic has caused nearly 780 million cases globally. While available treatments and vaccines have allowed a reduction of the mortality rate, the spread of the virus is still evolving quickly, resulting in the emergence of new variants. Despite extensive research, the long-term impact of SARS-CoV-2 infection is still poorly understood and requires further investigation.
Routine analysis provides limited access to the tissues of patients, necessitating alternative approaches to investigate viral dissemination in the organism. We addressed this issue by implementing a whole-body in vivo imaging strategy to longitudinally assess the biodistribution of SARS-CoV-2. We demonstrate in a COVID-19 non-human primate model that a single injection of non-neutralizing radiolabeled [89Zr]COVA1-27-DFO human monoclonal antibody targeting a preserved epitope of the SARS-CoV-2 spike protein allows longitudinal tracking of the virus by positron emission tomography with computed tomography (PET/CT). Convalescent animals exhibited a persistent [89Zr]COVA1-27-DFO PET signal in the lungs, as well as in the brain, three months following infection. This imaging approach also allowed detection of the virus in various organs, including the airways and kidneys, of exposed animals during the acute phase of infection. Overall, the technology we developed offers a comprehensive assessment of SARS-CoV-2 distribution in vivo and provides a new approach for the non- invasive study of long-COVID physiopathology.
MiRNA-29b accelerates the PDGF in exosomes and stimulates hepatic stellate cells to promote liver fibrosis in biliary atresia
Authors: Liao Xilin , Liu Rui , Zhou Teng , Zhao Xiaohuan , Xiong Xiangang , Zhang Kaizhi , Zheng Zebing , Xia Xingrong , Tang chengyan , Gong Yuan , Du Qing , Huang Lu , Zhu Daiwei , Zhou Wankang , Liu Yuanmei , Jin Zhu 
Published: October 2024

Abstract

Background
Biliary atresia (BA) is one of the most common liver diseases in infants and young children. Its etiology and pathogenesis are still unclear. The purpose was to investigate the mechanism by which the highly expressed miRNA-29b in exosomes regulates the high expression of PDGF through methylation, hepatic stellate cell activation, and participation in the hepatic fibrosis of BA.
Methods
In previous experiments, peripheral blood exosomes of children with biliary atresia and cholangiectasia (CC) were analyzed, and it was found that miRNA-29b was highly expressed in the exosomes of children with BA. Meanwhile, PDGF was highly expressed.Jurkat cells were infected with lentivirus overexpressing miRNA-29b, and the exosomes of Jurkat cells were extracted and cocultured with hepatic stellate cells (LX-2).
Results
DNMT3a and DNMT3b expression was downregulated and PDGFA expression was upregulated in the miR-29b overexpression group, which activated hepatic stellate cells. DNMT3a/3b was identified as the target gene of miR-29b by luciferase assays. Downregulation of DNMTs resulted in hypomethylation of the PDGF promoter region and high expression of PDGFA. Western blot analysis showed increased expression of COL1A1 and α-SMA, and CCK-8 analysis showed increased proliferation of LX-2 cells.
Conclusions
Our study showed that miRNA-29b was highly expressed in peripheral blood exosomes and that PDGFA was highly expressed in liver tissues in children with BA. Exosomes overexpressing miRNA-29b caused hypomethylation of the DNA promoter region of PDGFA in hepatic stellate cells, promoted the high expression of PDGFA, activated hepatic stellate cells, and participated in BA-associated liver fibrosis, elucidating the pathogenesis of BA.
Qualitative study of experience of patients with external drainage tube out of hospital with biliary and pancreatic system diseases
Authors: LIU Jingli , WANG Qianqian , YE Xiaoping , Xie Lixia , WU Ziyu , HUANG Doudou , YAO Yanrong 
Published: October 2024

Abstract

Objective: This study aimed to understand the experience of patients with external drainage tube out of hospital with biliary and pancreatic system diseases and provide a theoretical basis and reference for formulating nursing intervention measures based on the actual experience of patients with ducts.
Methods: An objective sampling method was used to select patients treated in the Department of Hepatobiliary Surgery and the Pipeline Nursing Outpatient Department of a triple A hospital in Yinchuan City, Ning Xia province, China, and had external drainage tubes in place outside the hospital for more than one month as research objects. Semi-structured interviews were conducted under the guidance of phenomenological research methods, and 17 participants were finally included. This study was reviewed by the Research Ethics Committee of the General Hospital of Ningxia Medical University (Ethics number: KYLL-2022-1341), and all subjects voluntarily participated in this study.
Results: Four themes and ten sub-themes were extracted, including negative experiences in social life (reinforcement of patient role and absence of family role, changes in work, life, and lifestyle), physical and mental discomfort experience (negative psychological experience and physical discomfort experience), lack of related knowledge (lack of disease-related knowledge, lack of pipeline nursing skills, and weak consciousness). and hope to get help (obtain the appropriate size of the drainage bag, improve fixed film, and the follow-up method).
Conclusion: The patients’ experience of patients with drainage tube outside of hospital for hepatobiliary and pancreatic system diseases is primarily discomfort. There are some discomfort experiences and a lack of relevant-disease knowledge, and patients are eager to get professional help from the medical staff.
Lower Water-soluble Vitamins and Higher Homocysteine Levels Contribute to Cognitive Decline in Patients with Neurodegenerative Diseases: a retrospective case-control study
Authors: Zhang Cuiping , Hu Yao , Cao Xinyi , Deng Yuhang , Wang Yuting , Wu Xiaoyan , Jiang Haoqin 
Published: October 2024

Abstract

Background: Evidence of the effectsof water-soluble vitamins (e.g., vitaminB, vitamin C, and folic acid [FA]) on cognitive function in patients with neurodegenerative diseases is mixed. Furthermore, the relationships among homocysteine (Hcy) metabolism, water-soluble vitamins, and cognitive decline remain unclear. Therefore, we aimed to investigate the role of the levels of water-soluble vitamins (e.g., vitamins B1, B2, B3, B5, B6, B9, B12, and C and FA) and Hcy in dementia progression in patients with neurodegenerative diseases.
Methods: In this retrospective cohort study, we enrolled 280 healthy controls and 646 patients with a neurodegenerative disease. Patientswere classified into a Parkinson’s disease (PD) group (n = 312), Alzheimer’s disease (AD) group (n = 219), orother dementia group (n = 115) according to pathological features. The other dementia group comprised 25 patients with frontotemporal dementia, 38 with Lewy body dementia, 34 with vascular dementia, and 18 with semantic dementia. Serum vitamins (i.e., B1, B2, B3, B5, VB6, B9, and C) were measured via liquid chromatography-mass spectrometry/mass spectrometry. Total Hcy and plasma vitamin B12 and FA levels were measured using commercial electrochemiluminescence immunoassays.
Results: The serum levels of vitamins B1, B2, B5, B6, B9, and C were lower in all patient groups than in the control group. The logistic regression results revealed that lower levels of serum vitamins B2, B6, B9, and B12 were associated with a higher risk of dementia in PD patients, and higher Hcy levels and lower serum vitamin B6 and B9 levels were associated with a higher risk of AD-relatedcognitive impairment. In addition, the level of vitamins was positivelycorrelated with neuropsychological assessment scoresand negatively correlated with Hcy level and stage of dementia.
Conclusions: The levels of several water-soluble vitamins are lower in dementia patients. Moreover, lower levels of water-soluble vitamins and higher levels of Hcy may be associated with a higher risk of developing dementia. These findings suggest that estimating water-soluble vitamin levels in older adults may be valuable given that they may help improve cognitive function.
The association between school bullying involvement and Internet addiction among Chinese Southeastern adolescents: a moderated mediation model with depression and smoking
Authors: She Yuhang , Li Liping 
Published: October 2024

Abstract

Background
School bullying and Internet addiction are both common public health problems for adolescents. Several studies found an association between school bullying and Internet addiction; however, the underlying mediating and moderating mechanisms of the complex relationship between school bullying and Internet addiction are limited.
Objective
This study explored the mediating role of depression in the relationship between school bullying and Internet addiction and whether smoking moderated the relationship between school bullying and depression in Chinese Southeastern middle school students.
Methods
A cross-sectional study was conducted in Guangdong Province in Southeast China in June 2021. Associations between Internet addiction, school bullying, and depression were estimated using Spearman correlation analysis, the mediation effect and moderation effect were examined using Model 4 and Model 7 in the Hayes' PROCESS macro.
Results
The results included 1992 adolescents, 23.5% and 28.0% of participants reported experiences of school bullying and Internet addiction, respectively. There was a significant correlation between school bullying, depression, and internet addiction (p < 0.01). Depression partially mediated the association between school bullying and internet addiction, and smoking played a moderating role between school bullying and depression.
Conclusions
This study highlights the mediating and moderating mechanisms between school bullying and Internet addiction among Chinese Southeastern adolescents, providing the implication that depression and smoking interventions should be important in the prevention of Internet addiction among Chinese Southeastern adolescents.
A novel model of care; Telemedicine and peer support for HCV care among HIV infected people who inject drugs in remote Myanmar: A retrospective study
Authors: Tun Ni Ni , Smithuis Frank , Tun Nyan Lynn , Hteik Myo Min Min , Lynen Lutgarde , Conlon Christopher P. , Gils Tinne , Olmen Josefien van , Decroo Tom 
Published: October 2024

Abstract

Background: People who inject drugs (PWID) are at a heightened risk of co-infection with HIV and hepatitis C virus (HCV), which adversely affects health outcomes. Uncontrolled HCV can lead to increased transmission rates among PWID, highlighting the urgent need for improved access to treatment as a public health priority. Despite the availability of effective HCV treatments, access remains limited, particularly in remote areas, where stigma further complicates care. Implementing integrated and differentiated HCV care in these regions could help address this gap. This study evaluated a novel care model in remote settings, where general practitioners delivered integrated HCV-HIV care, telemonitored by specialists and supported by community health workers and peer educators. We evaluated treatment outcomes and associated predictors.
Methods: We used routine program data from the HCV treatment register to assess treatment completion rates and sustained virologic response (SVR) among PWID. SVR was defined as an undetectable HCV viral load 12 weeks after treatment completion. Patients who achieved SVR were invited for retesting at one year to calculate the one-year SVR rate. Logistic regression analyses were performed to identify predictors of both SVR and one-year SVR.
Results: Among 314 HIV-HCV co-infected PWID who initiated HCV treatment, 93.0% completed it, 96.2% had 12-week HCV-RNA results, and 77.9% achieved SVR. After one year, 67.7% (126 of 186) maintained SVR. Methadone maintenance therapy (aOR: 2.22; 95% CI: 1.09-4.55) and advanced liver disease—fibrosis (aOR: 2.33; 95% CI: 1.05-5.16) and cirrhosis (aOR: 3.21; 95% CI: 1.13-9.10)—were significantly linked to one-year SVR (p ≤ 0.05).
Conclusion: A novel care model involving general practitioners, specialist telemonitoring, and support from community actors has shown effectiveness for most HIV-HCV co-infected PWIDs. However, further qualitative research is needed to enhance SVR rates and better understand the reasons behind incomplete follow-up.
Metachronous small-bowel metastasis from pancreatic cancer presenting as anemia approximately 5 years postpancreatoduodenectomy: a case report
Authors: Tseng Ching-Wei , Tseng I-Tsou , Wu Chang-Che 
Published: October 2024

Abstract

Background: Intraductal papillary mucinous neoplasm (IPMN) is a premalignant cystic neoplasm originating from the pancreatic duct, with a risk of progression to pancreatic cancer. Surgical resection of IPMN has favorable outcomes, yielding high overall and disease-free survival rates. However, the incidence of malignant change or metastasis after surgical resection requiring repeat surgery remains high. Intestinal metastasis from pancreatic cancer, particularly after primary surgery, is extremely rare. Systemic treatments, including chemotherapy and radiotherapy, are typically used. Nevertheless, although surgery is not generally indicated, emerging research shows that it can be possibly beneficial for some patients
Case presentation: A 56-year-old female with a history of stage III nasopharyngeal cancer (T2N1M0), treated with concurrent chemoradiotherapy in 2012, was diagnosed with IPMN-associated pancreatic cancer (pT1cN0M0) in 2019. The tumor was located in the pancreatic head and the patient underwent a pancreaticoduodenectomy without adjuvant therapy. In early 2023, the patient developed chronic anemia(hemoglobin 8–9 g/dL) without gastrointestinal bleeding. Despite unremarkable endoscopic and computed tomography (CT) findings, a positron emission tomography-CT scan revealed a hypermetabolic lesion in the jejunum. Biopsy confirmed adenocarcinoma of pancreatic origin, consistent with metastasis. In January 2024, re-resection of the jejunal metastasis and biliary reconstruction were performed. The patient recovered uneventfully, and pathology confirmed pancreatic adenocarcinoma metastasis.
Conclusion: This case presents a rare occurrence of jejunal metastasis following pancreaticoduodenectomy for IPMN-associated pancreatic cancer. Successful re-resection of the metastatic lesion highlights the potential role of surgery in select cases of oligometastatic recurrence. While chemotherapy remains the standard treatment for metastatic pancreatic cancer, surgical intervention should be considered in patients with limited recurrence, particularly when complete tumor resection is feasible. Regular surveillance with imaging and tumor markers is essential for early detection of recurrence and improving long-term outcomes.