bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial dynamics of caudatoside and ptaquiloside in bracken ferns in Northern Europe
Authors: Kisielius Vaidotas , Markussen Bo , Hansen Hans Christian Bruun , Rasmussen Lars Holm 
Published: September 2024

Abstract

Bracken ferns (genus Pteridium) are among the most prevalent plants worldwide, with their distribution expanding due to their invasive nature. The environmental implications of their proliferation in areas affected by human activity, natural disasters, or land-use changes are concerning, primarily because of the carcinogenic illudane glycosides they produce. These compounds cause domestic and wildlife animal poisoning, as well as contamination of dairy products and drinking water. Several illudane glycosides are known, but usually only ptaquiloside (PTA) is monitored. This study investigates the spatial and temporal variations in illudane glycosides PTA, caudatoside (CAU) and ptesculentoside (PTE) across two phenotypes of Pteridium aquilinum (vars. aquilinum and latiusculum) over a broad geographic range spanning Denmark, Sweden, and Finland, encompassing 66 locations. We analysed plant samples (LC-MS) and statistically explored the influence of phenotype, frond part, geographic location, exposure to sunlight, and the surrounding forest ecosystem on glycoside content. Our findings reveal that PTA accounts for approximately two-thirds of the total illudane glycoside content, followed by CAU at nearly one-third, and a minor contribution from PTE. Glycoside levels were not influenced by phenotypic variations or the studied environmental factors but were significantly affected by geographic location. Specifically, CAU levels increased progressively towards the northeast, while PTA concentrations were highest in Denmark and markedly decreased in northeastern countries by over threefold, presumably due to climatic gradient. It has been further supported by temporal analysis in selected PTA-dominant regions indicating a reduction in PTA towards the end of the growing season, aligning its levels with those of CAU. Our study highlights that CAU concentrations in bracken ferns may equal or surpass PTA, contesting the prevailing view that PTA is the only notable illudane glycoside in Bracken. To provide unbiased assessment of the potential risks posed by P. aquilinum in the region, environmental and toxicological research should include measurements of not only PTA, but also CAU and, if possible, PTE.
Bioengineered extracellular vesicles presenting PD-L1 and Gal-9 to ameliorate new-onset primary ovarian insufficiency (POI)
Authors: Zhou Guannan N. , Gu Yuanyuan , Ding Jingxin , Lu Guanming , Hua Keqin 
Published: September 2024

Abstract

Primary ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction characterized by premature exhaustion of primordial follicles, which causes infertility and dysfunctions of many other organ systems including sexuality, bones, the cardiovascular system, and neurocognition. An important factor in the development of POI is immune dysregulation, which results in augmented T cell response in ovary. Thus, modulation of the ovarian infiltrated T lymphocytes by exogenous PD-L1 or Gal-9 is an ideal approach for treating POI. Herein, we genetic engineered the human umbilical cord mesenchymal stem cells (hucMSCs) derived extracellular vesicles (EVs) overexpressing PD-L1 and Gal-9, which could restrict the activity of ovarian autoreactive T lymphocytes and protect ovarian cells from destruction. Moreover, PD-L1-Gal-9 EVs prominently promoted effector T cell apoptosis in vitro, and reversed the decreased AMH in the POI mice as well as declined proportion of CD8+ T cells infiltrating the ovaries, which contributed to preventing POI progression and preserving the residual ovarian fertility.
Influence of ground motion characteristics on aftershock fragility of reinforced concrete TV tower subjected to mainshock-aftershock sequences
Authors: Li Hang , Zhou Changdong 
Published: September 2024

Abstract

After a major earthquake, multiple aftershocks often occur, and there is typically insufficient time to repair or reinforce structures between these events. Consequently, structures damaged in the mainshock may suffer greater damage or even collapse during subsequent aftershocks. Evaluating the seismic performance of reinforced concrete TV (RC-TV) towers is essential due to their critical role in signal propagation. Currently, the seismic design code and structural performance evaluation for RC-TV towers focus only on a single earthquake, overestimating the structure's seismic capacity during continuous seismic events. Because the mechanisms of mainshock and aftershock differ, the characteristics of aftershock can vary significantly from those of the mainshock. Therefore, this paper proposes an analytical framework to study the effects of mainshock-aftershock (MS-AS) sequence characteristics—such as ground motion magnitude, rupture distance, duration, and frequency content—on the aftershock fragility of RC-TV towers. A series of nonlinear time history analyses were conducted using real MS-AS sequence records, and the fragility curves of aftershocks following different mainshocks were obtained. The results show that the aftershock fragility of the structure is more affected by MS-AS sequences with large magnitude, distant fault, long duration and low frequency. As the degree of structural damage from the mainshock increases, the influence of aftershock fragility becomes more pronounced. This study comprehensively and reliably analyzes and evaluates the seismic performance of RC-TV towers under MS-AS sequences with different ground motion characteristics, providing valuable references for designers in safety design and managers in daily maintenance.
Association between Life's Essential 8 and psoriasis: insights from NHANES
Authors: Wang Wenjie , Li Guanru , Sun Liyun 
Published: September 2024

Abstract

Psoriasis is closely associated with cardiovascular diseases (CVD). This study aimed to investigate the relationship between Life's Essential 8 (LE8), a latest measure of cardiovascular health (CVH), and psoriasis.This population-based cross-sectional study utilized data from the 2009–2014 National Health and Nutrition Examination Survey, including a total of 7,072 participants.Multivariable logistic regression models and restricted cubic spline models were used to evaluate these correlations.Out of the 7072 participants, 204 had psoriasis.Psoriasis patients exhibited lower LE8 scores compared to non-psoriasis patients.Across all models,the high-score(80–100) group was significantly associated with a lower incidence of psoriasis compared to the low-score(0–49) group, showing a notable negative correlation between the two(OR [95% CI]: 0.437[0.225,0.810]; P<0.05).The restricted cubic spline model showed a linear association, with an LE8 value inflection point at 64.786.Negative associations were found between both health behavior and health factor scores and psoriasis. Specifically, the negative correlation was most pronounced for the nicotine exposure score.Consistent results were additionally observed in both subgroup and supplementary analyses.LE8 scores and its subscale scores were inversely related to psoriasis. Our study emphasizes that promoting optimal CVH levels may be beneficial in preventing and alleviating psoriasis.
Effect of TiO2 coating on structure and electrochemical performance of LiNi0.6Co0.2Mn0.2O2 cathode material for lithium ion batteries
Authors: Li Lin , Li Zhongyu , Kuang Zhifan , Yang Minjian , Liu Jianwen , Wang Shiquan , Liu Hongying 
Published: September 2024

Abstract

Many efforts have been made to improve the electrochemical performance of Ni-rich cathode materials, such as metal ion doping, surface modification, and fabricating nanostructured materials. Here, to enhance the electrochemical performance of the LiNi0.6Co0.2Mn0.2O2 (NCM622) cathode, NCM622 was coated by TiO2 layers through the sol-gel process. X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and electrochemical tests have been applied for material characterizations and electrochemical measurements. Compared with the pristine NCM622 electrode, the cycling stability and rate performance of the TiO2-coated NCM622 electrodes are significantly improved. Among all TiO2-coated NCM622, the NCM622 cathode with TiO2 coating content of 0.5% demonstrats a highest capacity retention of 89.3% and a discharge capacity of 163.9 mAh g− 1, in contrast to 80.9% and145 mAh g− 1 for the pristine NCM622 electrode, after 100 cycles at 0.3 C between 3-4.3 V. Under the high cutoff voltage of 4.6 V, the 5 wt% TiO2-coated.
NCM electrode exhibit better electrochemical properties than bare NCM622 in terms of specific capacity and cyclability, similar to the results measured at a cut-off voltage of 4.3 V. The results prove that TiO2 modification can lower the polarization of the material, effectively raising the cycling stability rate performance of the battery. It provides a reference path for the further progress of high capacity and stability ternary cathode materials.
Therapeutic effect of single intra-testicular injection of lyophilized xenogenous and allogeneic mesenchymal stem cell-derived extracellular vesicles on oligozoospermia in male dogs.
Authors: Mohamed Alaa , Shahat Khalid Hafez El , Fathi Mohamed , Shamaa Ashraf , M.Bahr Mohamed 
Published: September 2024

Abstract

Oligozoospermia is the most common cause of infertility in male canine reproduction. Practitioners look for specific therapies to solve this problem. So, the aim of the present investigation is to study for the first time the impact of a single intra-testicular injection of lyophilized canine and human MSCs-derived EVs on the oligospermia of male dogs. Dogs were randomly allocated into three groups. Group I is the control group (n = 5), without any treatment; Group II is the lyophilized canine MSCs-derived EVs (n = 5); and Group III is the lyophilized human MSCs-derived EVs (n = 5). Dogs were subjected to semen collection, blood collection, and Doppler examination. The assessment was performed on day 0 before injection, and the examination was extended to 8 weeks. The results showed that there was a notable (P ˂ 0.01) increase in testicular volume in either the canine or human MSCs-derived EVs group from the 6th to the 8th weeks of the study as compared to Day 0. The maximum volume of right or left testis in dogs treated with either canine or human MSCs-derived EVs was observed at 8 weeks post injections compared to Day 0 before treatments. The Doppler indices (PSV and EDV) were significantly improved in dogs treated with canine or human MSCs-derived EVs. The maximum values of PSV and EDV were attained in the 8th week following injection. However, the PI and RI of the testicular arteries were significantly decreased as compared to the Day 0 and control group. The human MSCs-derived EVs group had lower values of RI and PI than the canine MSCs-derived EVs group. The single intra-testicular injection of lyophilized canine MSCs-derived EVs resulted in a highly significant (P<0.001) increase in the sperm cell concentration, motility, live/dead ratio, and normal spermatozoa compared to those obtained in lyophilized human MSCs-derived EVs. In addition, the canine MSCs-derived EVs group showed higher values (P<0.001) of testosterone levels from 2nd to 8th weeks than those in the human MSCs-derived EVs group. The reverse trend was observed for NO levels. In conclusion, a single intra-testicular injection of MSCs-derived EVs could improve testicular vascularization by increasing Doppler velocities. In addition, it could improve semen quality, steroids (testosterone), and nitric oxide.
Seismic Performance of Reinforced Concrete Buildings in the 2021 Mamuju-Majene Earthquake Mw. 6.2, Sulawesi Indonesia
Authors: Arsyad Ardy , Asyhari Muhammad , Kaharuddin Mufidatul Azmi 
Published: September 2024

Abstract

The seismic performance of RC buildings in Mamuju in West Sulawesi of Indonesia during the 2021 Mamuju-Majene earthquake is examined. Despite the earthquake's recorded acceleration being just 0.26 g, or 25% of the predicted acceleration (1.027 g), it has resulted in the collapse of many RC buildings across the city of Mamuju. We conducted a post-earthquake investigation to uncover the mechanism of collapsing RC buildings, with the aim of learning lessons and gaining insights for improvement in RC building design. Extensive geotechnical and geophysical investigations reveal the ground motion in the city reached 0.68 g, or about 66% of the anticipated ground motion specified for the city of Mamuju on the provision of the Indonesia Code (SNI 1726-2019). This observation suggests that the traditional design of the current RC buildings may perform seismically poorly. Therefore, elastic linear modal analysis and non-linear static and dynamic analysis were conducted to uncover the failure process of the RC building during the earthquake. The results reveal that the collapse of the RC building starts with the formation of plastic hinges at the column members on the ground floor, whereas the column members on the first and second levels remain in an elastic state. Under these circumstances, the RC building's roof displacement exceeded the critical displacement for collapse prevention. For future prevention, a revised structural design has been suggested to enhance the seismic resistance of the RC building with target performance following the Indonesia Code SNI 1726-2019. Increasing the cross-section area of the column members of RC building over a fixed base foundation can result in a more rigid structure and a lower inter-story drift ratio.
High Education Level Women in China: maternal weight and Pregnancy Risks
Authors: Jing Gao , Shang Gao , Xiayi Wang , Li Min , Lei Chen , Fei Qin , Weiwei Cheng 
Published: September 2024

Abstract

Women’s educational interventions affect pregnancy via maternal weight. This retrospective study enrolled 24594 college and above women with singleton live birth. Multivariate logistic regression were performed to evaluate the impact of sociodemographic characteristics on pre-pregnancy body mass index (p-BMI) and gestational weight gain (GWG) values. Both logistic regression and heat maps were utilized to explore the association between the later factors and adverse pregnancy complications. High education women who were older, natives, above college, assisted reproductive technology, and multiparity tended to have higher p-BMI but control their GWG within the lower range. The multivariate analysis revealed that women who were underweight before pregnancy were at high risk of low birth weight (LBW) and small for gestational age (SGA). Overweight was associated with a high risk of hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), macrosomia, and large for gestational age (LGA). Obesity was also associated with an increased risk of preterm birth, GDM, HDP, macrosomia and LGA. Inadequate GWG was associated with a high risk of LBW, SGA, and preterm birth. Excess GWG might be associated with a high risk of macrosomia and LGA. Women with a high educational level common present with a normal BMI before pregnancy and adequate GWG but the percentage of low p-BMI and excess GWG is still high. Abnormal GWG and p-BMI before pregnancy are associated with increased risks of adverse pregnancy outcomes. In particular, more responsive preventive measures and effective management approaches are required for women with a high educational level.
Two distinct phenotypes of calcium oxalate stone formers could imply different long-term risks for renal function
Authors: Williams James C. , Bowen William S. , Lingeman James E. , Rivera Marcelino , Worcester Elaine M. , El-Achkar Tarek M. 
Published: September 2024

Abstract

Endoscopic and biopsy findings have identified two distinct phenotypes among individuals with calcium oxalate (CaOx) kidney stones. One phenotype exhibits normal renal papillae but shows interstitial mineral deposition, known as Randall's plaque. The other phenotype presents with collecting duct plugging and a higher incidence of loss of papilla tissue mass. With Randall’s plaque, renal papilla injury involves the loss of small patches of calcified tissue (Randall’s plaque detaching with the stone), which likely results in damage to only a few nephrons. In contrast, collecting duct mineral plugs are very large, causing obstruction to tubular flow. Since each terminal collecting duct drains thousands of nephrons, ductal plugs could lead to the degeneration of many nephrons and a significant loss of renal glomeruli. New visualization techniques for immune cells in papillary biopsies have revealed that the Randall's plaque phenotype is marked by the accumulation of macrophages around the plaque regions. In contrast, preliminary data on the plugging phenotype shows collecting duct damage with mineral plugs, increased T-lymphocytes throughout the papilla, and tubulitis, characterized by T-cell infiltration into nearby collecting duct epithelium. This suggests that while some CaOx stone formers may have some papillary inflammation but with minimal damage to nephrons, others suffer from obstruction to flow for many nephrons that may also include destructive inflammation in the renal tissue. We propose that the long-term risks for loss of renal function will be greater for CaOx stone formers with the plugging phenotype.
Are all robotic technologies created equal? Comparing one of the latest image-free robotic technologies to all other robotic systems for total knee arthroplasty
Authors: Huang Philip , Cross Michael , Gupta Anshu , Intwala Dhara , Ruppenkamp Jill , Hoeffel Daniel 
Published: September 2024

Abstract

Background: Robotic-assisted technologies have been developed to increase surgical precision and reduce surgical variability in total knee arthroplasty (TKA). Several different robotic systems have been introduced in the last decade for TKA. The DePuy Synthes VELYSTM Robotic-Assisted Solution (VRAS) is an imageless system designed to eliminate the need for preoperative CT scans and is one of the latest entrants in the rapidly evolving field of robotic technology in TKA. This study compared the clinical and economic outcomes associated with VRAS compared to other robotic-assisted technology for primary TKA.
Methods: A retrospective cohort study using the Premier Healthcare Database included patients who received their primary TKA with VRAS compared with other robotic-assisted technologies from January 1, 2022, to April 30, 2023. The primary outcome for the study was hospital follow-up visits (revisits) within 90 days post-TKA. Secondary outcomes included readmission and revision rates within 90-day post-TKA, operating room time, length of stay, discharge status and hospital costs. Cohorts were balanced using propensity score fine stratification and generalized linear models were constructed to evaluate outcomes.
Results: The study included 827 VRAS TKA cases and 16,428 TKA cases performed with other robotic-assisted technologies. The 90-day all-cause and knee-related revisit rates were statistically significantly lower for VRAS compared to other robotic-assisted technologies (all-cause 13.9% vs. 22.8% and knee-related 2.8% vs. 5.4%, respectively, p-value < 0.01). The all-cause and knee-related 90-day readmission rates were also lower for VRAS though the differences were not statistically significant. 90-day revision rates were similar for VRAS and other robotic-assisted technologies (0.48% vs. 0.45%), as was operating room time (138 vs. 137 minutes). The 90-day knee-related cost for the VRAS cohort was $15,048 compared to $16,867 for other robotic technologies.
Conclusions: This database study demonstrates that early post-operative revisit rates and total cost of care is lower for VRAS compared to the class of all other robotic-assisted technologies for TKA, while operating room time and discharge status were similar. These are important findings in ever-evolving healthcare systems which are increasingly cost-conscious and cognizant of principles associated with value-based care.
Inhibition of GPX4 Induces the Death of p53-Mutant Triple-Negative Breast Cancer Cells
Authors: Tahaney William M. , Qian Jing , Lanier Amanda , Moyer Cassandra L. , Nguyen Nghi , Ma Yanxia , Hill Jamal , Powell Reid T. , Stephan Clifford C. , Davies Peter J.A. , Mazumdar Abhijit , Brown Powel H. 
Published: September 2024

Abstract

Background
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high rates of tumor protein 53 (TP53) mutation and with limited targeted therapies. Despite being clinically advantageous, direct targeting of mutant TP53 has been challenging. Therefore, we hypothesized that p53-mutant TNBC cells rely upon other potentially targetable survival pathways.
Methods
In vitro and in silico screens were used to identify drugs that induced preferential death in TP53-mutant cells. The effect of the glutathione peroxidase 4 (GPX4) inhibitor ML-162 was tested both in vitro and in vivo and the mechanism of cell death following GPX4 inhibition or knockout was determined.
Results
High-throughput drug screening demonstrated that p53-mutant TNBCs are highly sensitive to peroxidase, cell cycle, cell division, and proteasome inhibitors. We further characterized the effect of the Glutathione Peroxidase 4 (GPX4) inhibitor ML-162 and demonstrated that ML-162 induces preferential ferroptosis in p53-mutant TNBC cells. Treatment of p53-mutant xenografts with ML-162 suppressed tumor growth and increased lipid peroxidation in vivo. Testing ferroptosis inducers demonstrated p53-missense mutant, and not p53-null or wild-type cells, were more sensitive to ferroptosis, and expression of mutant p53 genes in p53-null cells sensitized cells to ML-162 treatment. Finally, we demonstrated that p53 mutation correlates with ALOX15 expression, which rescues ML-162 induced ferroptosis.
Conclusions
This study demonstrates that p53-mutant TNBC cells have unique survival pathways that can be effectively targeted. Our results illustrate the intrinsic vulnerability of p53-mutant TNBCs to ferroptosis and highlight GPX4 as a promising target for the precision treatment of p53-mutant TNBC.