bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender, Religion, and Political Violence: Lessons from Muslim Women’s Experiences in UK Elections
Authors: Akhtar Parveen , Jenichen Anne , Intezar Hannah 
Published: September 2024

AbstractViolence against women in politics is on the rise, threatening political achievements with respect to equality. Little research, however, has been conducted on the experiences of women from minority communities. This article, therefore, takes an intersectional approach to explore how gender, religion, and other categories of difference intersect when it comes to Muslim women’s experiences in the UK. Based on a longitudinal case study of Bradford West during the 2015, 2017, and 2019 general elections that combines participant observations, qualitative interviews, and a Twitter analysis, we argue that, in addition to the violence often experienced by women, Muslim women are also confronted with Islamophobic bias and abuse, as well as intersectional intimidation and harassment from within the Muslim community in their constituencies. Our case study approach, however, also reveals the existence of appreciation and support for Muslim women in politics that needs to be nurtured to counter abuse.
Politics without Presence? The Symbolic Representation of Trans People in Germany and the Netherlands
Authors: Schotel Anne Louise , Mügge Liza 
Published: September 2024

AbstractHistorically, trans people have been excluded from politics. Despite political under representation, trans interests increasingly appear on the political agenda in the Netherlands and Germany. In 2021, trans women were elected to the Dutch and German parliaments for the first time. However, increased trans visibility is accompanied by backlash and transphobia. The political representation of trans people does not follow a familiar pattern from elected descriptive representatives to increased substantive representation of interests. What mechanisms shape the political representation of trans people? We argue that symbolic representation shapes possibilities for descriptive and substantive representation of trans people. The analysis of symbolic representation of transpeople draws on a combination of 1) qualitative text analysis of Dutch and German parliamentary documents, research reports, and trans activists’ publications and 2) in-depth interviews with trans andcisgender representatives, candidates, and activists. The findings demonstrate how political spaces are not only gendered, but also cisgendered and heteronormative.
Job Talk: Candidate Gender and Presentation of Prior Experience in Television Ads in the US
Authors: Hansen Eric R. , Mautner Connor 
Published: September 2024

AbstractDoes gender influence how candidates in the United States present their prior political experience to voters? Messaging one’s experience might demonstrate a history of power-seeking behavior, a gender role violation for women under traditional norms. As a result, men should be more likely to make experience-based appeals than women candidates. For evidence, we analyze the contents of 1,030 televised advertisements from 2018 state legislative candidates from the Wesleyan Media Project. We find that ads sponsored by experienced men are significantly more likely to highlight experience than ads sponsored by experienced women. However, we find that women’s and men’s ads are roughly equally likely to discuss work experience, suggesting that men’s greater emphasis on experience is limited to prior officeholding. The results contribute to our understanding of gender dynamics in political campaigns, the information available to voters, and how advertising shapes the criteria voters use to assess candidates.
Effectiveness of group problem management plus in distressed Syrian refugees in Türkiye: a randomized controlled trial
Authors: Acarturk C. , Kurt G. , İlkkurşun Z. , de Graaff A. M. , Bryant R. , Cuijpers P. , Fuhr D. , McDaid D. , Park A. L. , Sijbrandij M. , Ventevogel P. , Uygun E. 
Published: September 2024

Abstract

Aims
Despite high levels of psychological distress, mental health service use among Syrian refugees in urban settings is low. To address the mental healthcare gap, the World Health Organization developed group problem management plus (gPM+), a scalable psychological intervention delivered by non-specialist peer facilitators. The study aimed to evaluate the effectiveness of gPM+ in reducing symptoms of depression and anxiety among Syrian refugees in Istanbul, Türkiye.

Methods
A randomized controlled trial was conducted among 368 distressed (Kessler Psychological Distress Scale, K10 > 15) adult Syrian refugees with impaired functioning (World Health Organization Disability Assessment Schedule, WHODAS 2.0 > 16). Participants were recruited between August 2019 and September 2020 through a non-governmental organization providing services to refugees. Participants were randomly allocated to gPM+ and enhanced care as usual (gPM+/E-CAU) (184 participants) or E-CAU only (184 participants). Primary outcomes were symptoms of depression and anxiety (Hopkins Symptom Checklist (HSCL-25)) at 3-month follow-up. Secondary outcomes were post-traumatic stress disorder (PTSD) symptoms (PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders-5; PCL-5), functional impairment (WHODAS 2.0), and self-identified problems (psychological outcome profiles).

Results
Intent-to-treat analyses showed no significant effect of gPM+ on symptoms of anxiety, depression, PTSD and self-identified problems. Yet, there was a significant reduction in functional impairment in gPM+/E-CAU compared to E-CAU at 3-month follow-up (adjusted mean difference 1.66, 95 % CI 0.04, 3.27, p = 0.045, d = 0.19). Post-hoc subgroup analyses among participants with probable baseline depression or anxiety showed that there was a small but significant reduction in depression (adjusted mean difference −0.17, 95 % CI −0.32, −0.02, p = 0.028, d = 0.27) and anxiety (adjusted mean difference −0.21, 95 % CI −0.37, −0.05, p = 0.009, d = 0.30) symptoms comparing gPM+/E-CAU to E-CAU only at 1-week post assessment, but not at 3-month follow-up. There was a significant difference between conditions on functional impairment at 3-month follow-up, favouring gPM+/E-CAU condition (adjusted mean difference −1.98, 95 % CI −3.93, −0.02, p = 0.048, d = 0.26).

Conclusion
In this study in an urban setting in Türkiye, gPM+ did not alleviate symptoms of depression and anxiety among Syrian refugees experiencing psychological distress and daily living difficulties. However, participants with higher distress at baseline seemed to benefit from gPM+, but treatment gains disappeared in the long term. Current findings highlight the potential benefit of tailored psychosocial interventions for highly distressed refugees in volatile low-resource settings.
Volcanic Precursor Revealed by Machine Learning Offers New Eruption Forecasting Capability
Authors: Wang Kaiwen , Waldhauser Felix , Tolstoy Maya , Schaff David , Sawi Theresa , Wilcock William S. D. , Tan Yen Joe 
Published: September 2024

AbstractSeismicity at active volcanoes provides crucial constraints on the dynamics of magma systems and complex fault activation processes preceding and during an eruption. We characterize time‐dependent spectral features of volcanic earthquakes at Axial Seamount with unsupervised machine learning (ML) methods, revealing mixed frequency signals that rapidly increase in number about 15 hr before eruption onset. The events migrate along pre‐existing fissures, suggesting that they represent brittle crack opening driven by influx of magma or volatiles. These results demonstrate the power of unsupervised ML algorithms to characterize subtle changes in magmatic processes associated with eruption preparation, offering new possibilities for forecasting Axial's anticipated next eruption. This analysis is generalizable and can be employed to identify similar precursory signals at other active volcanoes.
Enhanced “Wind‐Evaporation Effect” Drove the “Deep‐Tropical Contraction” in the Early Eocene
Authors: Ren Zikun , Zhou Tianjun , Guo Zhun , Zuo Meng , He Linqiang , Chen Xiaolong , Zhang Lixia , Wu Bo , Man Wenmin 
Published: September 2024

AbstractThe equatorward contraction of tropical precipitation, commonly referred to as the “deep‐tropical contraction”, is witnessed in the paleoclimate simulations of the early Eocene. However, the mechanism driving this contraction is still unclear. Based on the energetics framework of the Intertropical Convergence Zone (ITCZ) and the decomposition method of the latent heat flux along with the simulations of a climate system model, CESM1.2, we proposed a novel mechanism responsible for the “deep‐tropical contraction” in the early Eocene. The greenhouse gases‐induced sea surface warming amplifies the sensitivity of evaporation to surface wind speed changes through Clausius‐Clapeyron scaling, leading to an interhemispheric asymmetric enhancement of the latent heat flux. To maintain hemispheric energy balance, the cross‐equatorial atmospheric energy transport must be reduced during the solstice seasons. As a result, the solstitial location of the ITCZ shifts equatorward, causing the “deep‐tropical contraction” in the early Eocene.
A New Ecosystem Model for Arctic Phytoplankton Phenology From Ice‐Covered to Open‐Water Periods: Implications for Future Sea Ice Retreat Scenarios
Authors: Choi Jang‐Geun , Matsuoka Atsushi , Manizza Manfredi , Carroll Dustin , Dutkiewicz Stephanie , Lippmann Thomas 
Published: September 2024

AbstractTo predict ecosystem change in the Arctic Ocean, understanding Arctic phytoplankton phenology is essential. We develop a marine ecosystem model focusing on phytoplankton dynamics and the competition for multiple resources based on knowledge from in situ data obtained in the Chukchi Sea. The model is designed to include the unique ecological characteristics of the Arctic Ocean. To the best of our knowledge, this is the first model successfully simulating the current paradigm for Arctic phytoplankton phenology, including both under‐ice blooms and succession of phytoplankton groups. Sensitivity experiments show that the dominance of diatoms can be sustained by lateral transport of a high‐silicate water mass (Pacific Winter Water). Experiments for future scenarios show that sea ice retreat drives a decrease in large diatoms and an increase in the other relatively small non‐diatom groups. These results suggest that dominant phytoplankton groups can be shifted from diatoms to non‐diatoms under ongoing Arctic Ocean sea ice retreat.
Latitudinal Mapping of Chorus Waves Growth Rates Based on Multi‐Spacecraft Wave and Plasma Measurements
Authors: Voshchepynets A. , Agapitov O. V. , Mourenas D. , Artemyev A. , Hlebena M. , Bryla A. 
Published: September 2024

AbstractWhistler mode chorus waves are one of the most intense and important electromagnetic emissions in the Earth's radiation belt, where these waves are responsible for electron acceleration to relativistic energies and for energetic electron precipitation into the Earth's atmosphere. This study reports a unique multi‐spacecraft observation event that allowed for the first time to verify theoretical models of chorus wave generation. The growth rates derived from the multi‐spacecraft observations of chorus waves Cluster WBD electric field waveforms collected during the crossing of the equatorial source region were compared to the theoretical linear and nonlinear growth rates calculated using simultaneous PEACE electron measurements. We have revealed that the growth rate estimated from wave measurements is substantially higher than the estimated linear growth rate but is quite close to the estimated nonlinear growth rate. A notable wave amplification is found up to 5 degrees of magnetic latitude and higher.
Why Does Atmospheric Radiative Heating Weaken Midlatitude Cyclones?
Authors: Mischell Eric , Soden Brian , Zhang Bosong , Hsieh Tsung‐Lin , Vecchi Gabriel 
Published: September 2024

AbstractRecent work has indicated that atmospheric radiative heating reduces the kinetic energy of large‐scale eddies in the midlatitudes. However, a physical mechanism that connects radiation to the midlatitude eddy kinetic energy is still uncertain. Using a high‐resolution general circulation model we perform an experiment in which the radiative cooling profile at each model time step is overwritten with the climatological mean, computed from a control simulation. This approach separates the mean and transient effects of radiative heating on the extratropical circulation. We find that, when radiative heating is fixed, the globally‐averaged eddy kinetic energy is enhanced by ∼6%. We show that thermal radiation dampens temperature anomalies near the surface and tropopause in low‐pressure systems, destroying eddy available potential energy and eddy kinetic energy. We identify this as a possible mechanism by which atmospheric radiative heating weakens midlatitude cyclones.
Ubiquitin-independent degradation of Bim blocks macrophage pyroptosis in sepsis-related tissue injury
Authors: Shi Peilin , Du Yingying , Zhang Yunyan , Yang Bo , Guan Qiujing , Jing Yiming , Tang Hao , Tang Jianguo , Yang Chunhui , Ge Xiaoli , Shen Shihui , Li Lei , Wu Chunrong 
Published: September 2024

AbstractPyroptosis, a typical inflammatory cell death mode, has been increasingly demonstrated to have therapeutic value in inflammatory diseases such as sepsis. However, the mechanisms and therapeutic targets of sepsis remain elusive. Here, we reported that REGγ inhibition promoted pyroptosis by regulating members of the gasdermin family in macrophages. Mechanistically, REGγ directly degraded Bim, a factor of the Bcl-2 family that can inhibit the cleavage of GSDMD/E, ultimately preventing the occurrence of pyroptosis. Furthermore, cecal ligation and puncture (CLP)-induced sepsis model mice showed downregulation of REGγ at both the RNA and protein levels. Gasdermin-mediated pyroptosis was augmented in REGγ-knockout mice, and these mice exhibited more severe sepsis-related tissue injury. More importantly, we found that REGγ expression was downregulated in clinical sepsis samples, such as those from patients with Pseudomonas aeruginosa (PA) infection. Finally, PA-infected mice showed decreased REGγ levels in the lung. In summary, our study reveals that the REGγ-Bim-GSDMD/E pathway is a novel regulatory mechanism of pyroptosis in sepsis-related tissue injury.
CD226 implicated in Akt-dependent apoptosis of CD4+ T cell contributes to asthmatic pathogenesis
Authors: Zhang Yuan , Xie Yang , Zhang Xuexin , Duan Chujun , Ma Jingchang , Wang Yuling , Wu Yilin , Shan Niqi , Cheng Kun , Zhuang Ran , Bian Ka 
Published: September 2024

AbstractAsthma is a chronic airway inflammatory disease in which CD4+ T cell dysregulation occurs. Here, we investigated the molecular role and clinical significance of CD226, a costimulatory molecule of T lymphocytes, in the development of allergic asthma. Our results revealed that the expression of CD226 was significantly increased in CD4+ effector T cells, especially in T helper (Th) 2 cells and Th17 cells in patients with asthma. Moreover, CD4+ T cell-specific Cd226-knockout mice were generated and together with littermates were challenged with ovalbumin (OVA) to establish a model of allergic asthma. We found that CD226 deficiency in CD4+ T cells mitigated lung inflammation, IgE production, and eosinophil infiltration and reduced airway remodeling in experimental allergic asthma. However, the impact of CD226 on asthma was independent of Treg cell modulation. Through RNA-seq data analysis, the apoptosis pathway was screened. Mechanistically, CD226 deletion promoted CD4+ T cell late apoptosis via the activation of Caspase-3 in an Akt-dependent manner. Furthermore, blocking CD226 signaling with a recombinant fusion protein attenuated asthma features in mice and achieved a good therapeutic effect. Overall, this study revealed a unique role of CD226 in CD4+ T cell regulation in asthma pathogenesis. Therefore, targeting CD226 may provide new insights into the clinical treatment of asthma.
Cholesterol inhibition enhances antitumor response of gilteritinib in lung cancer cells
Authors: Sun Chao-Yue , Cao Di , Wang Yue-Ning , Weng Nuo-Qing , Ren Qian-Nan , Wang Shuo-Cheng , Zhang Mei-Yin , Mai Shi-Juan , Wang Hui-Yun 
Published: September 2024

AbstractRepositioning approved antitumor drugs for different cancers is a cost-effective approach. Gilteritinib was FDA-approved for the treatment of FLT3-mutated acute myeloid leukemia in 2018. However, the therapeutic effects and mechanism of Gilteritinib on other malignancies remain to be defined. In this study, we identified that gilteritinib has an inhibitory effect on lung cancer cells (LCCs) without FLT3 mutation in vitro and in vivo. Unexpectedly, we found that gilteritinib induces cholesterol accumulation in LCCs via upregulating cholesterol biosynthetic genes and inhibiting cholesterol efflux. This gilteritinib-induced cholesterol accumulation not only attenuates the antitumor effect of gilteritinib but also induces gilteritinib-resistance in LCCs. However, when cholesterol synthesis was prevented by squalene epoxidase (SQLE) inhibitor NB-598, both LCCs and gilteritinib-resistant LCCs became sensitive to gilteritinib. More importantly, the natural cholesterol inhibitor 25-hydroxycholesterol (25HC) can suppress cholesterol biosynthesis and increase cholesterol efflux in LCCs. Consequently, 25HC treatment significantly increases the cytotoxicity of gilteritinib on LCCs, which can be rescued by the addition of exogenous cholesterol. In a xenograft model, the combination of gilteritinib and 25HC showed significantly better efficacy than either monotherapy in suppressing lung cancer growth, without obvious general toxicity. Thus, our findings identify an increase in cholesterol induced by gilteritinib as a mechanism for LCC survival, and highlight the potential of combining gilteritinib with cholesterol-lowering drugs to treat lung cancer.
CRISPR/Cas9 editing of NKG2A improves the efficacy of primary CD33-directed chimeric antigen receptor natural killer cells
Authors: Bexte Tobias , Albinger Nawid , Al Ajami Ahmad , Wendel Philipp , Buchinger Leon , Gessner Alec , Alzubi Jamal , Särchen Vinzenz , Vogler Meike , Rasheed Hadeer Mohamed , Jung Beate Anahita , Wolf Sebastian , Bhayadia Raj , Oellerich Thomas , Klusmann Jan-Henning , Penack Olaf , Möker Nina , Cathomen Toni , Rieger Michael A. , Imkeller Katharina , Ullrich Evelyn 
Published: September 2024

AbstractChimeric antigen receptor (CAR)-modified natural killer (NK) cells show antileukemic activity against acute myeloid leukemia (AML) in vivo. However, NK cell-mediated tumor killing is often impaired by the interaction between human leukocyte antigen (HLA)-E and the inhibitory receptor, NKG2A. Here, we describe a strategy that overcomes CAR-NK cell inhibition mediated by the HLA-E-NKG2A immune checkpoint. We generate CD33-specific, AML-targeted CAR-NK cells (CAR33) combined with CRISPR/Cas9-based gene disruption of the NKG2A-encoding KLRC1 gene. Using single-cell multi-omics analyses, we identified transcriptional features of activation and maturation in CAR33-KLRC1ko-NK cells, which are preserved following exposure to AML cells. Moreover, CAR33-KLRC1ko-NK cells demonstrate potent antileukemic killing activity against AML cell lines and primary blasts in vitro and in vivo. We thus conclude that NKG2A-deficient CAR-NK cells have the potential to bypass immune suppression in AML.
Contrasting genomic epidemiology between sympatric Plasmodium falciparum and Plasmodium vivax populations
Authors: Schwabl Philipp , Camponovo Flavia , Clementson Collette , Early Angela M. , Laws Margaret , Forero-Peña David A. , Noya Oscar , Grillet María Eugenia , Vanhove Mathieu , Anthony Frank , James Kashana , Singh Narine , Cox Horace , Niles-Robin Reza , Buckee Caroline O. , Neafsey Daniel E. 
Published: September 2024

AbstractThe malaria parasites Plasmodium falciparum and Plasmodium vivax differ in key biological processes and associated clinical effects, but consequences on population-level transmission dynamics are difficult to predict. This co-endemic malaria study from Guyana details important epidemiological contrasts between the species by coupling population genomics (1396 spatiotemporally matched parasite genomes, primarily from 2020–21) with sociodemographic analysis (nationwide patient census from 2019). We describe how P. falciparum forms large, interrelated subpopulations that sporadically expand but generally exhibit restrained dispersal, whereby spatial distance and patient travel statistics predict parasite identity-by-descent (IBD). Case bias towards working-age adults is also strongly pronounced. P. vivax exhibits 46% higher average nucleotide diversity (π) and 6.5x lower average IBD. It occupies a wider geographic range, without evidence for outbreak-like expansions, only microgeographic patterns of isolation-by-distance, and weaker case bias towards adults. Possible latency-relapse effects also manifest in various analyses. For example, 11.0% of patients diagnosed with P. vivax in Greater Georgetown report no recent travel to endemic zones, and P. vivax clones recur in 11 of 46 patients incidentally sampled twice during the study. Polyclonality rate is also 2.1x higher than in P. falciparum, does not trend positively with estimated incidence, and correlates uniquely to selected demographics. We discuss possible underlying mechanisms and implications for malaria control.
Universal correlation between H-linear magnetoresistance and T-linear resistivity in high-temperature superconductors
Authors: Ayres J. , Berben M. , Duffy C. , Hinlopen R. D. H. , Hsu Y.-T. , Cuoghi A. , Leroux M. , Gilmutdinov I. , Massoudzadegan M. , Vignolles D. , Huang Y. , Kondo T. , Takeuchi T. , Friedemann S. , Carrington A. , Proust C. , Hussey N. E. 
Published: September 2024

AbstractThe signature feature of the ‘strange metal’ state of high-Tc cuprates—its linear-in-temperature resistivity—has a coefficient α1 that correlates with Tc, as expected were α1 derived from scattering off the same bosonic fluctuations that mediate pairing. Recently, an anomalous linear-in-field magnetoresistance (=γ1H) has also been observed, but only over a narrow doping range, leaving its relation to the strange metal state and to the superconductivity unclear. Here, we report in-plane magnetoresistance measurements on three hole-doped cuprate families spanning a wide range of temperatures, magnetic field strengths and doping. In contrast to expectations from Boltzmann transport theory, γ1 is found to correlate universally with α1. A phenomenological model incorporating real-space inhomogeneity is proposed to explain this correlation. Within this picture, superconductivity in hole-doped cuprates is governed not by the strength of quasiparticle interactions with a bosonic bath, but by the concentration of strange metallic carriers.