bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the relation of injury to pain—an infant perspective*
Authors: Fitzgerald Maria 
Published: October 2024

Abstract
Forty-five years ago, Patrick Wall published his John J Bonica lecture “On the relation of injury to pain.”
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In this lecture, he argued that pain is better classified as an awareness of a need-state than as a sensation. This need state, he argued, serves more to promote healing than to avoid injury. Here I reframe Wall's prescient proposal to pain in early life and propose a set of different need states that are triggered when injury occurs in infancy. This paper, and my own accompanying Bonica lecture, is dedicated to his memory and to his unique contribution to the neuroscience of pain. The IASP definition of pain includes a key statement, “through their life experiences, individuals learn the concept of pain.”
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But the relation between injury and pain is not fixed from birth. In early life, the links between nociception (the sense) and pain (the need state) are very different from those of adults, although no less important. I propose that injury evokes three pain need states in infancy, all of which depend on the state of maturity of the central nervous system: (1) the need to attract maternal help; (2) the need to learn the concept of pain; and (3) the need to maintain healthy activity dependent brain development.
The role of factor XIII in patient blood management
Authors: Žunić Miodrag , Vreča Nino , Bevc Sebastjan 
Published: October 2024

Factor XIII (FXIII), a plasma transglutaminase, is a coagulation factor that plays a crucial role in blood clotting and patient blood management. The studies have demonstrated that FXIII targets a wide range of additional substrates that have an important role in hemostasis, especially in posttraumatic patients, patients undergoing surgery or obstetrics, being involved in wound healing and tissue repair. Morover, FXIII deficiency has also been described and an extensive research has shown that FXIII deficiency is a rare coagulopathy that leads to longer bleeding time, perioperative and postoperative complications and slower wound healing.
Present article aims to overview the diverse functions of FXIII and to highlight its role in patient blood management.
Cervical myelopathy mistaken for complex regional pain syndrome: A case report
Authors: Bak Jiwon , Hwang Byeongmun 
Published: October 2024

Rationale:
Degenerative cervical myelopathy (DCM) is characterized by spastic gait impairment, upper limb dysfunction, and sphincter disturbances. The pathological mechanism involves a combination of mechanical compression and ischemic processes, which are most commonly associated with the narrowing of the vertebral canal. However, DCM requires differential diagnosis from diseases of the central nervous system that cause neuropathic pain, such as complex regional pain syndrome (CRPS) and postherpetic neuralgia.

Patient concerns:
This report presents a case of DCM misdiagnosed as CRPS. Delayed diagnosis can lead to residual symptoms and functional disability.

Diagnoses:
Definitive diagnosis requires a correlation between physical findings and imaging results. Magnetic resonance imaging is the modality of choice, and spinal cord compression is the hallmark finding.

Interventions:
Anterior cervical discectomy and fusion.

Outcomes:
At the 8-week postoperative follow-up, the patient reported reduced pain. Arm function was almost normal, and although the gait was unstable, he was able to walk without assistance.

Lessons:
DCM can be easily confused with CRPS or postherpetic neuralgia. Therefore, physicians should consider the presence of different neuropathic pain syndromes when neuropathic pain develops. Patients with prior conditions affecting the cervical spine should be aware of the potential development of cervical myelopathy.
Transvaginal double-layer parallel in-situ suturing for early complex vesicovaginal fistula repair: Case report
Authors: Liu Chuanfeng , Cao Shouxia , Liu Haiyan , Pang Qingtan , Zhao Zichao , Wang Fuming , Xia Yongqiang 
Published: October 2024

Rationale:
Complex vesicovaginal fistulas (VVFs) with large defects pose significant surgical challenges. Traditional repair methods often require extensive tissue separation and multilayer suturing, risking local blood supply and healing. This study introduces a novel modified transvaginal repair technique that simplifies the procedure while preserving tissue vascularity. It employs double-layer parallel in situ suturing for early repair of complex VVF.

Patient concerns:
A 50-year-old woman was admitted with continuous vaginal urine leakage for 4 days following trauma. Speculum examination revealed a 3-cm longitudinal oval laceration at the 11 o’clock position in the dorsal lithotomy site, with continuous fluid leakage through the fistula.

Diagnoses:
Self-inflicted complex VVF.

Interventions:
The patient underwent prophylactic placement of bilateral double-J stents and continuous catheterization, followed by surgical repair using a modified transvaginal technique involving double-layer parallel in situ suturing.

Outcomes:
Postoperative evaluations showed successful healing with no urinary leakage. The vaginal sutures were removed on day 24, and follow-up at 1 year confirmed no recurrence of the fistula or lower urinary tract symptoms, significantly improving the patient’s quality of life.

Lessons:
The modified transvaginal repair technique using double-layer parallel in situ suturing is a simple and effective approach for early repair of complex VVF, highlighting its potential for broader clinical application. Future studies with larger cohorts are needed to validate these findings.
Efficacy and safety of traditional Chinese medicine in managing bone loss post-endocrine therapy in hormone receptor-positive breast cancer patients
Authors: Chen Liuxiang , Zhang Yuanqi , Li Jianwen , Kalmar Attila 
Published: October 2024

Background:
This study aims to evaluate the efficacy and safety of traditional Chinese medicine (TCM) kidney-tonifying methods in treating bone loss and osteoporosis following endocrine therapy in patients with hormone receptor-positive breast cancer.

Methods:
This research systematically searched 6 major medical electronic databases, initially identifying 986 articles, ultimately including 22 randomized controlled trials. These studies encompassed a total of 1579 patients and investigated the impact of TCM kidney-tonifying methods on lumbar spine bone density, lumbar spine bone density T-values, femoral neck bone density, clinical efficacy, and drug safety. The Cochrane quality scoring system was utilized to assess the quality of the literature, and data were synthesized using meta-analysis techniques.

Results:
TCM kidney-tonifying methods significantly improved lumbar spine bone density (standardized mean difference [SMD] = 0.70, 95% confidence interval [CI]: 0.43–0.97) and lumbar spine bone density T-values (SMD = 1.012, 95% CI: 0.506–1.517). There was also a positive trend in enhancing femoral neck bone density (SMD = 0.645, 95% CI: 0.321–0.970). Although improvements in clinical efficacy did not reach statistical significance (relative risk [RR] = 1.122, 95% CI: 0.933–1.348), the studies indicated good safety of the treatment, with most studies reporting no significant adverse reactions.

Conclusion:
TCM kidney-tonifying methods may have a positive therapeutic effect on bone loss and osteoporosis following endocrine therapy in patients with hormone receptor-positive breast cancer, demonstrating good tolerability and safety. Given the current evidence, it is recommended to include TCM kidney-tonifying methods as a complementary therapeutic approach in treatment protocols. Future research should further validate these findings and explore their application in different patient subgroups.
A bibliometric analysis of global research on short chain fatty acids in neurological diseases
Authors: Zhao Jiuhong , Lei Yihan , Zhang Xinyuan , Li Zhihong 
Published: October 2024

Background:
The interest on short chain fatty acids (SCFAs) regulating the progress of neurological diseases has gained significant attention in recent years. This bibliometric analysis aimed to provide insights into the current state and future trends of global research on SCFAs in neurological research.

Methods:
To analysis the general trend of publications, the scientific output in this field from 1995 to 2024 was first retrieved from the Web of Science Core Collection, Scopus, and PubMed with SCFAs-related and neurological diseases related terms as the subjects. Based on above publication analysis, rapid development stage was marked as 2016 to 2024 and 878 relevant original articles in rapid development stage was retrieved with the time limit from 2016 to 2024. Key bibliometric indicators were calculated and evaluated using CiteSpace with these 878 articles.

Results:
SCFAs are related to the occurrence and development of neurological diseases. China and the USA have contributed in a significant way to foster a better understanding on SCFAs in neurological diseases. The hot theme of research have gradually shifted from neurodegenerative diseases to psychical diseases. In the aspect of mechanism research, the current hotspot is inflammation. SCFAs are able to modulate oxidative stress and microglia maturation, morphology and function to intervene in the development of neurological diseases and thus SCFAs interventions are promising to treat neurological diseases. 2016 to 2024 is the fast-developing stage in this field. In this stage the publications dramatically increased and were of high quality.

Conclusion:
SCFAs in neurological research will continue to be an active area in the near future. Future trends might be correlation analysis and neurotherapeutics of SCFAs on patients with psychical diseases and deeper mechanism research is still needed.
Relapsing polychondritis in childhood: A case report
Authors: Li Peng , Chen Zhipeng , Lv Huaiqing , Lin Liqiang 
Published: October 2024

Rationale:
Relapsing polychondritis (RP) is a rare immune-mediated disease that leads to progressive cartilage destruction, notably affecting the ears, nose, and airways. Timely diagnosis is essential to prevent irreversible airway damage and life-threatening complications. This study presents a case of a 12-year-old child diagnosed with RP, emphasizing the critical need for timely identification of RP in children.

Patient concerns:
A 12-year-old girl was admitted with worsening hoarseness and cough, leading to respiratory distress and severe bradycardia, requiring transfer to the pediatric intensive care unit. After successful resuscitation and tracheal intubation, imaging showed significant subglottic swelling. She received antibiotics, corticosteroids, and nebulization. Despite initial stabilization, she required a tracheostomy 2 months post-discharge due to recurrent dyspnea. Six months later, she developed joint pain and a saddle nose deformity.

Diagnoses:
The patient was clinically diagnosed with RP in accordance with the diagnostic standards set forth by Micheet et al.

Interventions:
During the initial phase of treatment, the patient was administered antibiotics, corticosteroids, and nebulization therapy. Due to severe respiratory distress, an emergency tracheostomy was performed by ear, nose, and throat surgeons. After a definitive diagnosis, the patient was treated with tocilizumab, methotrexate, and corticosteroid therapy. Additionally, supportive measures including calcium supplementation, gastric protection, and immune support were provided.

Outcomes:
Three years post-diagnosis, the patient’s condition is stable.

Lessons:
Due to RP low prevalence, diagnosis in children is frequently delayed or overlooked. Notably, involvement of the major airways is more common and severe in pediatric patients compared to adults. It is crucial for Otolaryngologists to have a comprehensive understanding of this condition to effectively diagnose and manage complications associated with RP.
Influence of nursing intervention on patients with recurrent bacterial vaginosis treated with sucrose gel
Authors: Chen Zhihui , Xing Aimin , Yang Rui , Hu ChunYang , Han Pengfei 
Published: October 2024

Background:
Bacterial vaginosis significantly affects gynecological health of women, and recurrence is common with a high prevalence in patients who received sucrose gel treatment. Evidence has found that nursing intervention has benefits in improving the rate of recurrence of gynecological diseases. The purpose of this study was to investigate the influence of nursing intervention on patients with recurrent bacterial vaginosis treated with sucrose gel.

Methods:
A total of 1096 patients with bacterial vaginosis were recruited and randomly divided into the intervention nursing group (n = 548) and the control group (n = 548) between May 2022 and October 2022. Patients with bacterial vaginosis in the nursing intervention group received the individualized nursing intervention program, while patients in the control group received routine nursing for vaginitis and follow-up. The clinical efficacy and the short form health survey MOS 36 items (SF-36) scale were used to evaluate the efficacy of nursing intervention efficacy in patients with vaginosis treated with sucrose gel.

Results:
Our results indicate that the nursing intervention was associated with significant improvements in physical functioning, depression, mental health, bodily vitality pain, and symptoms related to bacterial vaginosis compared to the control group patients. The social functioning-36 score in the nursing intervention group was higher than that in the control group during the 6-month period. Nursing intervention significantly decreased the recurrence of bacterial vaginosis via improvement quality of life and psychological states.

Conclusions:
In conclusion, the data in this study indicate that the nursing intervention improves recurrent bacterial vaginosis and the quality of life of patients treated with sucrose gel.
Infection prevention in home dialysis
Authors: Al Sahlawi Muthana , Chan Christopher T. , Perl Jeffrey 
Published: October 2024

Purpose of review
Among patients with kidney failure, home dialysis modalities, including peritoneal dialysis (PD) and home hemodialysis (HHD) provide several individual and healthcare system benefits over in-center hemodialysis (HD). Infection remains a major source of morbidity and mortality in this population, and a core outcome of critical importance to patients, caregivers, and kidney health professionals. This narrative review provides evidence-based measures for infection prevention among individuals receiving home dialysis, with a particular emphasis on dialysis and access-related infections.

Recent findings
Patient and care partner education and training is an important and major theme for infection prevention in home dialysis. In PD, identifying and managing modifiable risk factors for infections such as hypokalemia, constipation, use of gastric acid suppressants, and domestic pets, along with the use of antimicrobial prophylaxis, when indicated, can substantially reduce peritonitis risk. Reducing the use of central venous catheters (CVC), and duration of CVC dependence is the most effective means of prevention of HD access-related bloodstream infections in individuals receiving HHD. For arteriovenous fistula cannulation, rope ladder technique is associated with lower risk of infection compared to buttonhole cannulation.

Summary
Developing and instituting a well structured and evidence-based patient training and education program within home dialysis units is the most important measure in preventing and reducing dialysis and access-related infections. Kidney care providers should be familiar with different infection risk factors among individuals receiving home dialysis.
Effects of selective serotonin reuptake inhibitors on platelet functions: a literature review
Authors: Mokhtarian Antoine , Siguret Virginie , Jourdi Georges 
Published: October 2024

Purpose of review
Many epidemiological studies have evidenced an increased bleeding risk associated with selective serotonin reuptake inhibitors (SSRIs), yet the underlying mechanisms remain unclear. This review summarizes data on SSRIs’ effects on platelet functions assessed with assays used in clinical practice and highlights the areas that deserve further investigation.

Recent findings
Conflicting results of SSRI effects on platelet aggregation were observed irrespectively of the agonist used, the antidepressant drug or the study type. Alike, discrepant results were reported with flow-cytometry-based assays assessing either platelet surface glycoprotein levels, integrin activation, agonist-induced secretion of intraplatelet granule content or membrane anionic phospholipid exposure. Other tests may have detected a platelet function defect in SSRIs samples, however, results were largely inconsistent.

Summary
Critical literature examination unveils very low certainty of evidence on potential SSRI effect on platelet functions. Findings are often inconsistent even when similar methods are used, most likely because of differences in study design, included patients (age, comorbid conditions), SSRIs’ type and dose, uncontrolled confounding factors, and statistical analysis power. Further studies are needed to disentangle any intrinsic antiplatelet effect of SSRIs and the multiple confounding factors, mainly the depression control itself and the degree of platelet SERT inhibition.
Rethinking Surgical Safety: Investigating the Impact of Gamified Training on Severe Flow Disruptions in Surgery
Authors: Cohen Tara , Kanji Falisha , Zamudio Jennifer , Breese Catherine , Avenido Ray , Yoshizawa Christine , Bartkowicz Stephanie , Catchpole Kenneth , Anger Jennifer 
Published: October 2024

Objectives
There is a need for effective and engaging training methods to enhance technical and nontechnical skills in robotic-assisted surgery (RAS), where deficiencies can compromise safety and efficiency. This study aims to evaluate the impact of a gamified team training intervention, the “RAS Olympics,” on the safety and efficiency of RAS procedures.

Methods
The study was conducted at a 958-bed tertiary care academic medical center in with a robust robotic surgery program. A total of 56 RAS procedures (general, urology, and gynecology) were included in the analysis, with a mix of procedure types representative of the surgical caseload at the medical center. A pretest posttest experimental design was employed, comparing the frequency and severity of flow disruptions (FD) between preintervention, postintervention without “RAS Olympics” participants, and postintervention with “RAS Olympics” participants. The “RAS Olympics” involved safety hazard identification, troubleshooting, workspace navigation, instrument retrieval, and turnover optimization.

Results
Postintervention cases with “RAS Olympics” participants exhibited significantly lower overall FDs compared to the postintervention control group. The reduction was particularly notable during phase 3 (surgeon on console) and in cases involving more severe FDs.

Conclusions
Gamified team training interventions may improve the safety and efficiency of RAS procedures. The positive outcomes underscore the potential of innovative and engaging training methods to address the evolving challenges in surgical practice, emphasizing the relevance of gamification in healthcare education. As the healthcare landscape continues to advance, incorporating such interventions may be crucial in ensuring the adaptability and competence of surgical teams.
68Ga-DOTATATE and 18F-FDG PET/CT in a Rapidly Progressing Lymphoma
Authors: Parihar Ashwin Singh , Wahl Richard L. , Jahromi Amin H. 
Published: October 2024

Abstract

68Ga-DOTATATE PET/CT targeting somatostatin receptors is commonly utilized in the imaging of neuroendocrine tumors. However, other malignancies such as lymphomas (both Hodgkin and non-Hodgkin) also have expression of somatostatin receptors, albeit to a lesser degree compared with the neuroendocrine tumors, and thus can be positive on a 68Ga-DOTATATE PET/CT. We describe an atypical presentation of an aggressive large B-cell lymphoma mimicking a metastatic neuroendocrine tumor at initial presentation with high somatostatin receptor expression demonstrated on the 68Ga-DOTATATE PET/CT and a rapidly progressing course on the subsequent 18F-FDG PET/CT.
Glove Phenomenon Detected by Total-Body PET/CT With 68GA-DOTATATE
Authors: Nalbant Hande , Mingels Clemens , Sen Fatma , Spencer Benjamin A. , Riess Jonathan W. , Nardo Lorenzo 
Published: October 2024

Abstract
Accidental intra-arterial injections of radiotracers are rare events resulting in a specific imaging pattern, described as “hot-forearm,” “hot-hand,” “glove-phenomenon,” or “glove-like pattern.” We present a case 68Ga-DOTATATE total-body PET/CT for restaging of a neuroendocrine tumor, where intra-arterial misinjection resulted in a glove phenomenon. Since patients may present with minimal symptoms, like in this case, and PET findings may only be seen at the distal upper extremity (placed above the head), these accidental injections may be more frequently detected with total-body PET/CT due to the longer field-of-view. Radiologists and technologists should be aware of this possibility to avoid accidental misinjections.
Knockout offatty acid elongase1homeoalleles in amphidiploidBrassica juncealeads to undetectable erucic acid in seed oil
Authors: Patra Neelesh , Barker Guy C. , Maiti Mrinal K. 
Published: October 2024

SummaryIndian mustard (Brassica junceaL.) is a major oilseed crop with significant economic and nutritional importance within the Indian subcontinent. While its seed oil offers valuable dietary benefits, including a balanced ratio of human essential fatty acids, the traditional high oil-yielding varieties contain an elevated level of erucic acid (EA, C22:1) that is associated with adverse health effects. Therefore, developing low erucic acid (LEA) mustard cultivars is crucial for broader utilization and consumer safety. In this study, we employed CRISPR/Cas9 genome editing tools to disrupt thefatty acid elongase1(FAE1) gene that encodes a key enzyme in EA biosynthesis in two high erucic acid (HEA)B. junceacultivars, PCR7 and JD6. Targeted knockout (KO) ofBjFAE1homeoalleles (BjFAE1.1andBjFAE1.2) in this amphidiploid plant using CRISPR/Cas9 constructs, each carrying two guide RNAs led to monoallelic and biallelic mutations. Biallelic KO lines showed a near-complete elimination of EA (<0.5% in PCR7, undetectable in JD6) with a significant increase in nutritionally beneficial oleic acid (∼30% in PCR7, ∼35% in JD6), while the content of essential fatty acids also increased significantly, suggesting rerouting of carbon flux from EA biosynthesis. Importantly, these LEA lines retained key agronomic traits like plant seed yield and oil content, matching the productivity of the control elite cultivars. Our findings underscore the effectiveness of CRISPR/Cas9 technology for editingB. junceagenome, producing LEA seed oil lines with improved nutritional quality and thus expanding the applications of this important oilseed crop.