bluuebunny/crossref_metadata_2025_split huggingface dataset:
“It's Not Me, It's Not Really Me.” Insights From Patients on Living With Systemic Sclerosis: An Interview Study
Authors: Sumpton Daniel , Thakkar Vivek , O'Neill Sean , Singh‐Grewal Davinder , Craig Jonathan C. , Tong Allison 
Published: January 2017

ObjectivePatients with systemic sclerosis (SSc) experience severe physical limitations and psychological morbidity, but their lived experience remains underrepresented and is reflected in the scarcity of evidence‐based patient‐centered interventions. We aimed to describe patients’ perspectives of SSc to inform strategies to improve their care.MethodsFace‐to‐face semistructured interviews were conducted with 30 adult patients with limited cutaneous or diffuse cutaneous SSc in Australia. Transcripts were thematically analyzed using HyperRESEARCH software.ResultsSix themes were identified: bodily malfunction (restrictive pain, debilitating physical changes, pervasive exhaustion), deprivation of social function (loss of work and career, social isolation, threat to traditional roles, loss of intimacy), disintegration of identity (stigmatizing physical changes, disassociated self‐image, extinguished hopes, alone and powerless, invisibility of illness), insecurity of care (unrecognized disease, ambiguity around diagnosis and cause, information insufficiency, resigning to treatment limitations, seeking reassurance, fear of progression), avoiding the sick role (evading thoughts of sickness, protecting family, favorable comparison), and perseverance and hope (positive stoicism, optimism about treatment and monitoring, taking control of own health, pursuing alternative treatments, transcending illness through support).ConclusionSSc inflicts major bodily and social restrictions that crush patients’ identity and self‐image. Uncertainties about the cause, diagnosis, and prognosis can undermine confidence in care, leading to anxiety and therapeutic nihilism. Access to psychosocial care to support the patients’ role and functioning capacity, as well as communication and education that explicitly address their concerns regarding management may potentially improve treatment satisfaction, self‐efficacy, adherence, and outcomes in patients with SSc.
Phase transformation and mechanical properties of halloysite nanotubes‐modified isotactic polypropylene filaments
Authors: Lu Yang , Liu Chun 
Published: January 2017

ABSTRACTPhase transformation and mechanical properties of isotactic polypropylene (iPP) with well‐distributed 0.3, 0.8, and 1.2 wt % halloysite nanotubes (HNTs) are studied. The spatial distribution of HNTs in the iPP matrix is analyzed using transmission electron microscopy and found to be homogeneously dispersed. Phase transformation from molten to solid states is characterized by polarized optical microscopy under an isothermal condition at different temperatures and differential scanning calorimetric in cooling and heating at different rates. Average size of spherulites, the degree of undercooling and total solidification time of iPP decrease as the amount of HNTs increases, suggesting HNTs act as nucleation sites for iPP. More interestingly, the wide‐angle X‐ray diffraction analysis only showed the formation of the α‐form iPP crystallites for the extruded filament, while kinetics results indicating the existence of β‐form crystals. These results together demonstrated the presence of HNTs leads to heterogeneous phase distribution which enhances the mechanical strength of the iPP filaments without reducing their ability for elongation. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2017,134, 44714.
Modulare Stahllamellenhallen von Hugo Junkers
Authors: Tutsch Joram , Hipper Andreas , Schling Eike , Barthel Rainer 
Published: January 2017

AbstractDer für seine bahnbrechenden Erfindungen im Flugzeug‐ und Anlagenbau bekannte Ingenieur Hugo Junkers (1859–1935) entwickelte in den 1920er‐Jahren innovative Hallenkonstruktionen aus modularen Stahlblechlamellen, die weltweit vermarktet und gebaut wurden. Sie stehen in engem Kontext zur ebenfalls patentierten Holzbauweise Friedrich Zollingers (1880–1945). Die Bauweise gilt als Meilenstein in der Entwicklung des modularen Leichtbaus und bedeutendes Zeugnis der Moderne. Bedauerlicherweise sind nur noch wenige dieser Bauwerke erhalten.Auf dem Gelände des ehemaligen Militärflugplatzes Oberschleißheim stehen derzeit noch zwei dreischiffige, tonnenförmige Hallen von 1934. Die Hallen stehen unter Denkmalschutz, zeigen jedoch einen bedenklichen baulichen Zustand. Sie gaben den Anlass für ein Forschungsprojekt, das von 2014–2016 am Lehrstuhl für Tragwerksplanung der Technischen Universität München unter Förderung der Meitinger Stiftung bearbeitet wurde.Die wesentlichen Ergebnisse der Untersuchungen werden im Rahmen des Artikels zusammengefasst: Exemplarisch wurde ein Hallenschiff in Oberschleißheim mit einem 3‐D‐Laserscan vermessen und die Punktwolke in ein statisches Rechenmodell überführt. Parametrische Analysen brachten neue Erkenntnisse zur Geometrie und Fügung des Konstruktionsprinzips. Stu dien zum Tragverhalten zeigen verschiedene Schwachpunkte der Struktur auf, die für eine Instandsetzung unbedingt berücksichtigt werden müssen.
Relationship Closeness and Self‐reported Willingness to Falsely Take the Blame
Authors: Willard Jennifer , Guyll Max , Madon Stephanie , Allen Jacob E. 
Published: January 2017

AbstractOne reason people falsely confess is to protect the true perpetrator. The current study examined whether relationship closeness influences people's self‐reported willingness to falsely take the blame. Utilizing theoretical work from the prosocial area, three potential mediators were investigated. Participants (N = 131) were randomly assigned to think of either a close or a casual friend and then read one of two scenarios that described a minor offense committed by the friend. Participants' willingness to take the blame was assessed, as well as their perceptions of reciprocity, feelings of empathy, and distress concerns related to their relationship with the offending friend. Results showed that, in both scenarios, participants more often took the blame in the close friend condition than in the casual friend condition. Reciprocity and empathy each uniquely and independently mediated relationship closeness, whereas distress concerns did not. Differences in the two scenarios, which describe different offenses, are discussed. Copyright © 2017 John Wiley & Sons, Ltd.
High concentrations of LH cause virilization in a postmenopausal woman
Authors: Ahmad Iram , Anawalt Bradley D. 
Published: January 2017

Key Clinical MessageSome testosterone‐producing adrenal tumors can be successfully treated with long‐acting GnRH analogs and adrenal venous sampling can be useful to detect rare ectopic sex steroid‐producing tumors or confirm bilateral adrenal androgen hyperproduction in female hyperandrogenism.
Cyclic Steady‐State Behavior of a Fixed‐Bed Adsorptive Reactor for Reverse Water‐Gas Shift Reaction
Authors: Parra Alejandro A. Munera , Asmanoglo Carsten , Agar David W. 
Published: January 2017

AbstractProcesses to use CO2 on an industrial scale are few and far between. One proposal is to apply the reverse water‐gas shift reaction (rWGS) to activate CO2 and produce syngas, which is one of the most versatile feedstock. The rWGS needs high temperatures to yield a favorable equilibrium, which entails high costs. To circumvent the unfavorable equilibrium at lower temperatures, a fixed‐bed adsorptive reactor is proposed as a potential solution. The adsorption functionality leads to a periodic operation, due to the regeneration step. The cyclic steady‐state behavior of the system is modeled and then optimized based on a technical objective function. Improvements in the objective function of above 800 % can be achieved by manipulating the temperature and concentration profiles inside the reactor.
Triglyceride dependent differentiation of obesity in adipose tissues by FTIR spectroscopy coupled with chemometrics
Authors: Kucuk Baloglu Fatma , Baloglu Onur , Heise Sebastian , Brockmann Gudrun , Severcan Feride 
Published: January 2017

The excess deposition of triglycerides in adipose tissue is the main reason of obesity and causes excess release of fatty acids to the circulatory system resulting in obesity and insulin resistance. Body mass index and waist circumference are not precise measure of obesity and obesity related metabolic diseases. Therefore, in the current study, it was aimed to propose triglyceride bands located at 1770–1720 cm–1 spectral region as a more sensitive obesity related biomarker using the diagnostic potential of Fourier Transform Infrared (FTIR) spectroscopy in subcutaneous (SCAT) and visceral (VAT) adipose tissues.The adipose tissue samples were obtained from 10 weeks old male control (DBA/2J) (n = 6) and four different obese BFMI mice lines (n = 6 per group). FTIR spectroscopy coupled with hierarchical cluster analysis (HCA) and principal component analysis (PCA) was applied to the spectra of triglyceride bands as a diagnostic tool in the discrimination of the samples. Successful discrimination of the obese, obesity related insulin resistant and control groups were achieved with high sensitivity and specificity.The results revealed the power of FTIR spectroscopy coupled with chemometric approaches in internal diagnosis of abdominal obesity based on the spectral differences in the triglyceride region that can be used as a spectral marker.
magnified image
Cyclops lesions are associated with altered gait patterns and medial knee joint cartilage degeneration at 1 year after ACL‐reconstruction
Authors: Samaan Michael A. , Facchetti Luca , Pedoia Valentina , Tanaka Matthew S. , Link Thomas M. , Souza Richard B. , Ma C. Benjamin , Li Xiaojuan 
Published: January 2017

ABSTRACTIn this exploratory study, gait analysis and quantitative MRI (QMRI) were used to assess biomechanical differences in patients that present with cyclops lesions at 12 months after ACL‐reconstruction (ACLR). Thirty ACLR patients without and 10 ACLR patients with cyclops lesions underwent 3T MR T1ρ mapping of the reconstructed knee joint prior to ACLR and at 12 months after ACLR, as well as a gait assessment during a fixed walking speed at 12 months after ACLR. Both external sagittal and frontal plane knee joint moments and joint moment impulses were calculated and assessed throughout the stance phase of gait. ACLR patients with cyclops lesions demonstrated a significantly greater (34% larger, p = 0.03) first peak knee flexion moment (KFM) and KFM impulse (42% larger, p = 0.05), compared to those without cyclops lesions, which may suggest an increased load during the loading response phase of gait. There were no differences (p > 0.05) in knee extension or adduction joint moments or moment impulses. ACLR patients with cyclops lesions demonstrated a significantly increased change in T1ρ (ΔT1ρ = 4.7 ms, p = 0.03), over 12 months, within the central medial tibia. The results of the study suggest that ACLR patients with cyclops lesions demonstrate altered sagittal plane loading patterns which may be related to an increased rate of medial tibiofemoral cartilage degeneration at 12 months after ACLR. The first peak external KFM may be an important target for intervention programs in ACLR patients with cyclops lesions in order to possibly slow the onset or progression of medial tibiofemoral cartilage degeneration. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2275–2281, 2017.
Co‐Delivery of Docetaxel and p44/42 MAPK siRNA Using PSMA Antibody‐Conjugated BSA‐PEI Layer‐by‐Layer Nanoparticles for Prostate Cancer Target Therapy
Authors: Pang See‐Tong , Lin Feng‐Wei , Chuang Cheng‐Keng , Yang Hung‐Wei 
Published: January 2017

How to overcome the low accumulation of chemotherapeutic agent in tumor tissue and exhibit multitherapeutics remains an ongoing challenge for cancer treatment. Here, a simple method is demonstrated that used to prepare prostate‐specific membrane antigen antibody (PSMAab)‐conjugated fluorescent bovine serum albumin (BSA)‐branched polyethylenimine layer‐by‐layer nanoparticles (BSA‐PEILBL NPs) for co‐delivery of docetaxel (DTX) and p44/42 mitogen‐activated protein kinase (MAPK) small interfering RNA (p44/42 MAPK siRNA) as synergistic and selective inhibition of cancer cell proliferation platform. The results show the levels of α‐tubulin and p44/42 MAPK in CWR22R cells are significantly reduced after treatment with PSMAab‐conjugated DTX/BSA‐PEILBL/siRNA NPs. Consequently, the 50% cellular growth inhibition (IC50) values of the NPs loaded with both DTX and p44/42 MAPK siRNA are ≈2.1‐fold less than those for the NPs only loaded with DTX. The median survival significantly prolongs from 18 d to upward 45 d compared to mice that receive same dose (12 mg kg−1) of free DTX. The results suggest this synergistic delivery system may be a promising clinical treatment in prostate cancer.
image
The gut microbiome of hooded cranes (Grus monacha) wintering at Shengjin Lake, China
Authors: Zhao Guanghong , Zhou Lizhi , Dong Yuanqiu , Cheng Yuanyuan , Song Yunwei 
Published: January 2017

AbstractGut microbes of animals play critical roles in processes such as digestion and immunity. Therefore, identifying gut microbes will shed light on understanding the annual life of animal species, particularly those that are threatened or endangered. In the present study, we conducted nucleotide sequence analyses of the 16S rRNA genes of gut microbiome of the hooded cranes (Grus monacha) wintering at Shengjin Lake, China, by Illumina high‐throughput sequencing technology. We acquired 503,398 high‐quality sequences and 785 operational taxonomic units (OTUs) from 15 fecal samples from different cranes, representing 22 phyla that were dominated by Firmicutes, Proteobacteria, and Actinobacteria. A total of 305 genera were identified that were dominated by Clostridium, Lysinibacillus, and Enterobacter. The core gut microbiome comprised 26 genera, including many probiotic species such as Clostridium, Bacillus, Cellulosilyticum, and Cellulomonas that could catabolize cellulose. The findings reported here contribute to our knowledge of the microbiology of hooded cranes and will likely advance efforts to protect waterbirds that inhabit Shengjin Lake Reserve during winter.
Identification and bioactive potential of marine microorganisms from selected Florida coastal areas
Authors: Christensen Anna , Martin Glenroy D. A. 
Published: January 2017

AbstractThe ocean, with its rich untapped chemical biodiversity, continues to serve as a source of potentially new therapeutic agents. The evaluation of the diversity of cultivable microorganisms from the marine spongeHalichondria paniceaand ocean sediment samples were examined and their potential as sources of antimicrobial and antiproliferative agents were investigated. The marine sponge and sediments were collected at different depths (0.9–6 meters) and locations in Florida, including Florida Keys, Port St. Joe in Pensacola, Pensacola Bay, Pensacola Beach, and Fort Pickens. Twenty‐one cultivatable isolates were grouped according to their morphology and identified using 16SrRNAmolecular taxonomy. The bacterial community identified consisted of members belonging to the Actinobacteria, Bacteroidetes, Proteobacteria (Alpha‐ and Gamma‐classes) and Firmicutes phylogeny. Seven of the microbes exhibited mild to significant cytotoxic activities against five microbial indicators but no significant cytotoxic activities were observed against the pancreatic (PANC‐1) nor the multidrug‐resistant ovarian cancer cell lines (NCI/ADR). This work reaffirms the phyla Actinobacteria and Proteobacteria as sources of potential bioactive natural product candidates for drug discovery and development.
Semi‐interpenetrating polymer networks of methyl cellulose and polyacrylamide prepared by frontal polymerization
Authors: Rassu Mariella , Alzari Valeria , Nuvoli Daniele , Nuvoli Luca , Sanna Davide , Sanna Vanna , Malucelli Giulio , Mariani Alberto 
Published: January 2017

ABSTRACTIn this study, the feasibility of frontal polymerization (FP) as an alternative and convenient technique for the preparation of semi‐interpenetrating polymer networks made of methyl cellulose (MC) and cross‐linked polyacrylamide (PAAm) is demonstrated. FP was performed in water and glycerol, as largely available, nontoxic solvents. Although FP occurred in both media, differences were found by comparing the samples made in the two solvents. In particular, those prepared in water are characterized by larger inhomogeneity and less reproducibility, thus accounting for the boiling effects that influence propagating polymerization fronts when water was used. The effects of the ratio among MC and PAAm, the amount of cross‐linker and solvent medium were studied in terms of influence on temperature and velocity of FP fronts, glass transition temperature (dried samples), swelling behavior, dynamic‐mechanical properties (gels swollen in both water or glycerol), and tensile behavior. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 55, 1268–1274
Potential exposure to clothianidin and risk assessment of manual users of treated soil
Authors: Ren JingXia , Tao ChuanJiang , Zhang LiYing , Ning Jun , Mei XiangDong , She DongMei 
Published: January 2017

AbstractBACKGROUNDTreated soil is the second most prevalent application technique for all registered pesticides in China. Some developing countries also adopt this method. However, the safety of this scenario has not been reported in the literature. Experiments were therefore conducted to assess exposure using standard whole‐body dosimetry and air sampling methodologies.RESULTSDermal deposition was the main route of exposure in this scenario. The total dermal unit exposure (UE) of operators to clothianidin‐treated soil was 51.7 mg kg−1 AI handled (SD = 20.59, n = 16), and hands accounted for 36%. Inhalation UE was 0.04 mg kg−1 AI handled (SD = 0.02, n = 4), negligible compared with dermal exposure. Using an NOAEL (no observed adverse effect level) of 10 mg kg−1 day−1, the margin of exposure was 773, i.e. greater than 100.CONCLUSIONFor the first time, the scenario of treated soil exposure was assessed and was found to pose less risk than conventional pesticide application. These results can be used as a reference in pesticide management. © 2017 Society of Chemical Industry
Syntheses, Crystal structures, Magnetisms and Luminescences of two Series of Lanthanide Coordination Polymers Based on Tricarboxylic Ligand
Authors: Gao Chang‐Hui , Hou Guang‐Feng , Zuo Dian‐Fa , Jiang Wen‐Hong , Yu Ying‐Hui , Ma Dong‐Sheng , Yan Peng‐Fei 
Published: January 2017

AbstractTwo series of twelve polycarboxylate lanthanide coordination polymers (CPs), namely, [Ln(cpida)(H2O)]n{Ln=La (1), Ce (2), Pr (3) and Nd (4)} and {[Ln(cpida)(H2O)]⋅2H2O}n {Ln=Sm (5), Eu (6), Gd (7), Tb (8), Dy (9), Ho (10), Er (11) and Yb (12)} {H3cpida=N‐(4‐carboxyphenyl) iminodiacetic acid}, have been synthesized by self‐assembly and characterized by IR, TGA, X‐ray crystallography, powder XRD and elemental analysis. CPs 1–4 and 5–12 are isomorphic respectively, featuring 2D double layer structures. In CPs 1‐4, each metal atom connects five [cpida]3− anions and each ligand is bound to five metal cations. However, in 5‐12 each [cpida]3− anion only connects four metal cations due to the lanthanide contraction. Further, PL spectra of CPs 6, 8 and 12 show the strong characteristic luminescence of Eu(III), Tb(III) and Yb(III) ions, respectively, suggesting that [cpida]3‐ is able to sensitize the luminescence of lanthanide ions efficiently. The magnetic properties of Gd (7) and Dy (9) complexes have also been investigated.
Mild, Efficient and Catalyst‐Free Hydroxylation of Alkyl Halides in Water: Significant Enhancement of Water Nucleophilicity in Dipolar Solvents
Authors: Chougala Bahubali M. , Samundeeswari S. , Holiyachi Megharaja , Shastri Lokesh A. 
Published: January 2017

AbstractA new and efficient method for the hydroxylation of heteroarylalkyl, arylalkyl and alkyl halides has been developed by exploiting the nucleophilicity of water. The method being operated under neutral conditions, avoids acid/base or metal assisted catalysis. The protocol has been optimized for a range of aqueous aprotic/protic solvents. The new operation is very simple, highly economical, ecofriendly, safest and suitable for acid/base sensitive motifs in yielding the products at high purity.
Effective Production of 2,5‐Dimethylfuran from Biomass–derived 5‐Hydroxymethylfurfural on ZrO2‐doped Graphite Electrode
Authors: Yu Xueqing , Wen Yeqian , Yuan Tao , Li Gang 
Published: January 2017

AbstractThe 2,5‐dimethylfuran (DMF), a promising biofuel, was effectively produced from biomass‐derived 5‐Hydroxymethylfurfural (HMF) on a novel ZrO2‐doped graphite electrode by a two‐step method in this study. Firstly, the HMF was obtained from fructose using ZnCl2 as catalyst and NH4Br as promoter, and the highest yield of HMF reached 96 %. Then, the effective conversion of DMF from HMF was achieved on the ZrO2‐doped graphite electrode. The ZrO2 was characterized to be monoclinic phase. The highest yield of DMF reached 30.7 % on the 8 % ZrO2‐doped graphite electrode.
TBHP Promoted Cross‐Dehydrogenative coupling (CDC) Reaction: Metal/Additive‐Free Synthesis of Chromone‐Fused Quinolines
Authors: Singh Jay B. , Mishra Kalpana , Gupta Tanu , M.Singh Radhey 
Published: January 2017

AbstractA metal/additive‐free, TBHP‐promoted synthesis of 12H‐Chromeno[2,3‐b]quinolin‐12‐ones from 2‐phenoloxyquinolinyl‐3‐carboxaldehydes has been described via cross‐dehydrogenative coupling of aldehydic C−H bond with arene C−H bond in good to excellent yields. Reaction could be extended to the synthesis of Chromeno[2,3‐c]pyrazol‐4(1H)‐ones, 3‐Phenyl‐5H‐chromeno[2,3‐b]pyridin‐5‐ones and Xanthone respectively.
Rivalries of proximity beyond the household in Niger: political elites and thebaab-izeypattern
Authors: Olivier de Sardan Jean-Pierre 
Published: January 2017

AbstractIn Niger, there is an increasing rejection ofpolitik(a term with highly pejorative connotations): that is, party politics and the politics of democracy, characterized by personal rivalries and power struggles between clans and factions. But there is a direct link (albeit not a causal one) between the social perceptions of intra-familial rivalries and the social perceptions of political rivalries. The archetypical relationship among thebaab-izey(children of one father but different mothers) is characterized by competition and jealousy. This is a product of the latent rivalry that pits co-wives against each other. Polygamy is clearly at odds with a number of received ideas and clichés about ‘the African family’ as primarily a locus of support and solidarity. Such formal social norms may reign in public situations, but in private de facto practical norms give rise to subtle discriminations and the omnipresence of more or less hidden conflicts within the family. The same is true for the political microcosm of Niger. While the public norm of the concern for the public good is supposed to regulate political behaviours, rivalry and jealousy are structural components of the political world. Thebaab-izeypattern is frequently used in reference to politicians. Political conflicts are above all personal/factional conflicts in which friends and supporters are implicated, and are rivalries of proximity. In the familial space as in the political space, ‘magico-religious entrepreneurs’ (i.e. experts in the occult) are merely an ‘accelerator’ of these conflicts: they reinforce suspicions about the familial or political entourage, which, in turn, intensify rivalries.