bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of an Etoposide Chemotherapy Shortage on Patients With Extensive-Stage Small-Cell Lung Cancer: Results of a Natural Experiment
Authors: Browne Claire , Ayoub Toufic , Samarasinghe Nadeesha , Hussaini Syed , Warner Andrew , Black Morgan , Palma David A. , Raphael Jacques , Kuruvilla Sara , Blanchette Phillip S. 
Published: September 2024

PURPOSE A shortage of essential intravenous (IV) etoposide lasted from 2018 until 2020 in Ontario, Canada, allowing for a natural experiment in which external factors (IV etoposide availability) dictated patients' treatment assignment. The purpose of this study was to evaluate the impact of this IV etoposide shortage (IVES) on patient care outcomes. METHODS Individuals with extensive-stage small-cell lung cancer (ES-SCLC) treated during a pre-IVES (November 2017-October 2018) and IVES (November 2018-October 2019) time intervals were retrospectively reviewed at the Verspeeten Family Cancer Centre. We investigated the association of the shortage on health care utilization and survival using a time-to-event analysis, Cox proportional hazards and logistic regression modeling. RESULTS A total of 119 patients with ES-SCLC were assessed, 49 in the pre-IVES interval and 70 in the IVES interval. The median age was 68 (IQR, 62-74) years, 48% (n = 57) were male, 33% (n = 39) had CNS metastases, and 69% (n = 82) received first-line systemic therapy. Alternate regimens used for IVES cohort included IV platinum-oral (PO) etoposide, IV platinum-IV irinotecan, and PO etoposide monotherapy. An adjusted multivariable model demonstrated a significant increase in hospitalization (odds ratio, 2.30 [95% CI, 1.01 to 5.24]; P = .047) and shorter progression-free survival (PFS; hazard ratio, 1.79 [95% CI, 1.19 to 2.68]; P = .005) during the IVES. CONCLUSION This study demonstrated increased hospitalization, and decreased PFS, among patients with ES-SCLC treated with alternate chemotherapy regimens during an IVES. The impact of cancer drug shortages can be harmful, and optimizing a more secure drug supply with mitigation strategies is warranted.
Correlation of ammonia and blood laboratory parameters with hepatic encephalopathy: A systematic review and meta-analysis
Authors: Sepehrinezhad Ali , Moghaddam Negin Ghiyasi , Shayan Navidreza , Sahab Negah Sajad 
Published: September 2024

Background and objectives
Emerging research suggests that hyperammonemia may enhance the probability of hepatic encephalopathy (HE), a condition associated with elevated levels of circulating ammonia in patients with cirrhosis. However, some studies indicate that blood ammonia levels may not consistently correlate with the severity of HE, highlighting the complex pathophysiology of this condition.

Methods
A systematic review and meta-analysis through PubMed, Scopus, Embase, Web of Science, and Virtual Health Library were conducted to address this complexity, analyzing and comparing published data on various laboratory parameters, including circulating ammonia, blood creatinine, albumin, sodium, and inflammation markers in cirrhotic patients, both with and without HE.

Results
This comprehensive review, which included 81 studies from five reputable databases until June 2024, revealed a significant increase in circulating ammonia levels in cirrhotic patients with HE, particularly those with overt HE. Notably, significant alterations were observed in the circulating creatinine, albumin, sodium, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNFα) in HE patients.

Conclusions
These findings suggest an association between ammonia and HE and underscore the importance of considering other blood parameters such as creatinine, albumin, sodium, and pro-inflammatory cytokines when devising new treatment strategies for HE.
Are physiotherapists and occupational therapists following the guidelines for discharge summary?–An analysis of the content of physiotherapists’ and occupational therapists’ discharge summaries and their adherence to stroke guideline recommendations
Authors: Solbakken Liss Marita , Sundseth Antje , Langhammer Birgitta , Brovold Therese 
Published: September 2024

Purpose
Discharge summaries are important tools for communication between health care levels and can ensure continuity of rehabilitation. This study aims to gain insight into the content of discharge summaries written by hospital physiotherapists and occupational therapists regarding patients with stroke, and their adherence to recommended criteria for discharge summaries.

Material and methods
31 physiotherapy and multidisciplinary discharge summaries, for stroke patients discharged home from hospital with need of follow-up, were included in the study. We employed qualitative content analysis and descriptive statistics to explore and describe the content.

Results
The physiotherapists and occupational therapists adhered to the recommended criteria for content in varying degree. The main focus for physiotherapists and occupational therapists were description of ADL, sensorimotor and general cognitive functions, they rarely report tolerance to exercise, and the specific cognitive abilities to follow instruction and learn were often omitted. Less focus was put on patients’ experiences and needs during acute stroke, and description of goals were omitted in the physiotherapy discharge summaries.

Conclusion
While the physiotherapists and occupational therapists complement each other in their assessment of patients and inform the reader about both sensorimotor and cognitive functions and abilities, they omit some of the specific criteria for rehabilitation. Despite the omissions, the information provided is specific to the patients’ function and needs.
Effect of high-dose β-Alanine supplementation on uphill cycling performance in World Tour cyclists: A randomised controlled trial
Authors: Pérez-Piñero Silvia , Ramos-Campo Domingo Jesús , López-Román Francisco Javier , Ortolano Raquel , Torregrosa-García Antonio , Luque-Rubia Antonio Jesús , Ibáñez-Soroa Natalia , Andreu-Caravaca Luis , Ávila-Gandía Vicente 
Published: September 2024

Scientists and coaches seek effective ergogenic aids for performance improvement. Cyclists commonly use β-Alanine, which may enhance post-exercise recovery and physical performance. High-dose β-Alanine supplementation’s impact on World Tour cyclists during a 7-day camp remains unstudied. This study aimed to analyse the effect of a high dose of β-alanine in World Tour cyclist during a 7-day camp. A double-blinded, randomised controlled trial was conducted. 11 cyclists were included in the final analysis: β-alanine supplementation (n = 5; VO2max: 67.6±1.6 ml/kg/min) and a placebo group (n = 6; VO2max: 68.0±2.4 ml/kg/min). The duration of the supplementation protocol was seven days with four daily intakes. The subjects commenced supplementation after the physical tests (immediately following the snack) and consumed the final intake after breakfast on the day of the final test (a total of 7 days and 3 additional doses, 31 servings in total; 5g per dosage; 155g the total cumulative amount). Before and after seven days of supplementation, the cyclists performed an uphill time trial. Blood lactate, heart rate and rating of perceived exertion were measured during test. β-alanine supplementation improved the relative mean power attained during the time-trial compared with the control group (Z = -2.008; p = 0.045; Δ = 0.060), as well as the time needed to complete this trial (Z = -2.373; p = 0.018). As for physiological and metabolic variables, no significant change was found. In conclusion, the present study supports the effectiveness of one-week high dose of β-alanine during a cycling training in World Tour cyclists to improve their uphill time-trial performance. In addition, it is important to highlight the potential role of β-alanine in improving recovery power. This aspect is particularly relevant in the context of a training camp, where fatigue levels can increase alongside training intensity.
Trial registration: This study was registered in ClinicalTrials.gov: (identifier: NCT04427319).
Auf dem Acker wird schon lange nicht mehr nur Nahrung erzeugt
Authors: Mieritz Tina , Henningson Laura , Blessenohl Rebekka , Disselhoff Tilmann 
Published: September 2024

Solarfirmen bieten landwirtschaftlichen Betrieben hohe Pachtbeträge an, um Solarparks bauen zu können. Diese sind weitaus höher als das, was die Betriebe über den Anbau der ­meisten landwirtschaftlichen Kulturen erwirtschaften können. Für die Betriebe ergibt sich somit ein wirtschaftlich kaum auszuschlagendes Angebot.
Enhancing cross-cultural communication for Chinese tourists in non-native English-speaking destinations: a study of sociolinguistic competence and politeness challenges
Authors: An Gang , Lin Tan Debbita Ai 
Published: September 2024

Abstract
The current study explores the sociolinguistic challenges experienced by Chinese tourists. The purposive sampling approach was applied for data collection to comprehend the respondents’ communication hurdles. Online and offline questionnaires were also distributed to accommodate senior travellers. A total of 964 valid responses were gathered, which reflected the increasing trend of outbound tourism among Chinese nationals. The present study employed sociolinguistic competence as a mediating variable (specifically, its interplay with intercultural communication anxiety and politeness) within the Communicative Competence Model (CCM) framework. Several strategies that consider the nuanced aspects of language and culture are also proposed. The findings can potentially enhance service standards in the tourism sector by improving Chinese visitors’ intercultural communication experiences in various international destinations.
Linguocultural aspect of phraseological units (Guanyongyu) in modern Chinese language
Authors: Sabirova Madina , Kalibekuly Tolkyn , Jeldybayeva Raushan 
Published: September 2024

Abstract
The relevance of this study is primarily due to the constant influence of extra-linguistic factors (cultural, historical, and technological) on intralinguistic ones (plan of expression, semantics) in the modern Chinese phraseological picture of the world. The purpose of this study was to identify the main linguocultural features of Guanyongyu through the study of lexico-semantic and stylistic relations. The methods used in this study included analytical-synthetic, lexico-semantic, pragmatic, linguocultural, and statistical analyses. The key features of the group of Chinese phraseological units called Guanyongyu were indicated in the study: preservation of the connection between semantic components and the integral meaning of the phraseological unit, active structural transformations, use in everyday speech, 3 (rarely 4) syllable structure, high metaphoricity, and imagery. The study identified the following groups of “habitual expressions”: with somatic components, with metaphorical components, specifically with a zoonimic or botanical basis, as well as with key mythological or literary nominations. The study also considered different groups of phraseological units by stylistic colouring: negative, neutral, and positive. The analysis of phraseological units that emerged after the COVID-19 crisis showed that they usually had negative (more rarely positive) connotations and demonstrated the dominance of collective values over individual values. The following were identified as the main linguocultural features: negative connotations, satirical ridicule, use of somatic and zoonimic components, metaphorical transfers, dominance of the collective over the individual, connection with Chinese mythology, and literary images. In a further scientific perspective, this study can be used for comparative analysis of phraseological pictures of the world of different countries and nationalities and consideration of the basis of conceptualization through the analysis of cognitive aspects embedded in phraseological units.
Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
Authors: Hu Xianwen , Hu Hongyu , Li Dandan , Wang Pan , Cai Jiong 
Published: September 2024

Abstract

Purpose
This study aimed to assess the biodistribution and bioactivity of the affibody molecular probe 99mTc-(HE)3ZHER2:V2, prepared by genetic recombination, and to investigate its potential for targeted human epidermal growth factor receptor 2 (HER2) imaging in SKOV3 ovarian cancer and MDA-MB-361 breast cancer xenografts.

Methods
Affibody molecules were generated through genetic recombination. The radiochemical purity of the 99mTc-labeled HER2 affibody was determined using reverse phase high performance liquid chromatography (RP-HPLC). Evaluation of HER2 affinity in SKOV3 ovarian cancer cells and MDA-MB-361 breast cancer cells (HER2-positive) was conducted by calculating equilibrium dissociation constants. Biodistribution of the 99mTc-labeled affibody molecular probe was assessed in Balb/c mice bearing SKOV3 tumors. Tumor targeting specificity was evaluated in Balb/c mice using SKOV3, MDA-MB-361, and AT-3 (HER2-negative) xenografts.

Results
Affibody (HE)3ZHER2:V2, generated through recombinant gene expression, was successfully labeled with 99mTc, achieving a radiochemical purity of (96.0 ± 1.7)% (n = 3) as determined by RP-HPLC. This molecular probe exhibited specific binding to HER2-positive SKOV3 cells, demonstrating intense radioactive uptake. Biodistribution analysis showed rapid accumulation of 99mTc-(HE)3ZHER2:V2 in HER2-positive tumors post-administration, primarily clearing through the urinary system. Single-photon emission computed tomography imaging conducted 1–3 h after intravenous injection of 99mTc-(HE)3ZHER2:V2 into HER2-positive SKOV3 and MDA-MB-361 nude mouse models confirmed targeted uptake of the molecular probe by the tumors.

Conclusions
The molecular probe 99mTc-(HE)3ZHER2:V2 developed in this study effectively targets HER2 for imaging HER2-positive SKOV3 and MDA-MB-361 xenografts in vivo. It exhibits rapid blood clearance without evident toxic effects, suggesting its potential as a valuable marker for detecting HER2 expression in tumor cells.
Not happy to bleed
Authors: Sorgo Gabriele 
Published: September 2024

Abstract
Der technologische Trans- oder Posthumanismus entwirft Visionen eines human enhancement, die die Koevolution von Menschen mit ihren Maschinen feiern. Gegenüber diesem androzentrischen und z.T. religiös aufgeladenen Technikoptimismus wollte Donna Haraway mit ihrer Abhandlung über den/die Cyborg den Humanismus mit seinen Grenzziehungen zwischen Menschen und Artefakten ebenfalls in Frage stellen, aber zugleich auch die Geschlechterordnung. Daher hat sie in der Folge auch die Mensch-Tierbzw. KulturNatur-Grenzefür obsolet erklärt und einen kritischen Posthumanismus entworfen, der Entgrenzungen in vielerlei Richtungen andenkt statt nur in eine. Der Beitrag zieht die Menstruation, ihre Tabuisierung und Medikalisierung als Beispiel heran, um die angeführten Grenzziehungen im Spiegel der Diskurse über Selbstoptimierung und Tier-Werden zu analysieren. Aus historischanthropologischer Perspektive bedroht der zyklisch blutende Frauenkörper in gewisser Weise die westliche androzentrische Zivilisation, weil er die Unverfügbarkeit des Lebens (Zoé) reklamiert. In den Frauen und am Frauenkörper wird diese Unverfügbarkeit exkludiert und tabuisiert. Jacques Derridas Begriff der Divinanimalität verdeutlicht außerdem, warum die Grenze zwischen Tieren und Menschen, die auf den Frauenkörper projiziert und dort überwacht wird, nicht so einfach mit anderen Grenzziehungen gleichzusetzen ist.
Polyvalente Versuche der normalistischen Be- und Abgrenzung des Humanen in Präventionsmaßnahmen
Authors: Schmidt Friederike 
Published: September 2024

Abstract
Ausgehend von menschlichen Selbstverständigungen als Ansatzpunkt einer Analyse des Humanen befasst sich der Beitrag mit ernährungsbezogenen Präventionsmaßnahmen. Aus anthropologischer Perspektive lassen sich diese Maßnahmen als Versuch einordnen, die Nicht-Feststellbarkeit menschlicher Ernährung handhabbar zu machen. Wie an Konzeptionen verschiedener Präventionsmaßnahmen dabei gezeigt wird, sind diese im Bemühen einer Verbesserung der Lebensbedingungen und Möglichkeiten von Menschen auf verschiedenen Ebenen und in unterschiedlicher Weise mit Limitierungen des Mensch-Seins verbunden, die im Kern auf eine Normalisierung der Subjekte abzielen und die insofern im Beitrag als polyvalente Versuche der normalistischen Be- und Abgrenzung des Humanen näher präzisiert werden.
Limits of the Naturalization of Learning
Authors: Imai Yasuo 
Published: September 2024

Abstract
In the face of the dominant constructivist approach in contemporary learning theories, the naturalization of learning should be identified at a more fundamental level than its mere reduction to a biological phenomenon. It should be identified in the pervasive tendency to dispense with the experience the learners make about their own knowing. The trouble in the naturalization of learning can more clearly be realized by the concept of “space of nature/ reason.” The learning process includes bridging between both spaces; such bridging remains disregarded by reducing the learning to the event solely played in the space of nature. Following Buck’s argumentation, we can recognize an experience of a twofold leap from “nature” to “reason” in the procedural structure of learning. The limits of naturalization of learning are demarcated by the genuine condition of learning as experience.
Dating the Dawn of the Anthropocene
Authors: Wallenhorst Nathanaël 
Published: September 2024

Abstract
This article provides indepth insight into the debate (based on stratigraphic findings) as to the exact date that Earth entered the Anthropocene Epoch. Generally, in Human and Social Sciences, the date of the boundary is paid less attention than the systemic shifts resulting from it. (There have been a number of publications on our surpassing of the planet’s limits, and passing of the point of no return.) However, it is important to understand this debate based on stratigraphic data, because sooner or later, the International Union of Geological Sciences will amend the geological timescale to include the Anthropocene – even if, to date, the process of formal definition has been interrupted by the negative vote on 5 March 2024 of the Subcommission on Quaternary Stratigraphy (SQS) of the International Commission on Stratigraphy (ICS) after a positive vote in 2023 by the Anthropocene Working Group (AWG) proposing to date the onset of the Anthropocene in 1950 (with a “golden nail” in the Crawford lake beds). In future, almost all the world’s students will learn the date when we entered it. This article explores each of the possible dates when stratigraphic data suggest the Anthropocene may have started. This should hand tomorrow’s teachers the keys to understand what may sometimes seem an obscure expert debate.
Die neue Aktualität der Grenzen im Anthropozän
Authors: Wulf Christoph 
Published: September 2024

Abstract
Der Aufsatz untersucht die neue Aktualität von Grenzen. Er zeigt, dass sich im Anthropozän traditionelle Grenzen auflösen und neue entstehen. Die Begrenztheit des Planeten „Erde“ ist sichtbar und führt zu einem veränderten Verständnis des Planeten und zu neuen Menschen- und Weltbildern. Die Grenzziehungen zwischen Natur und Kultur, zwischen Biosphäre und Noosphäre greifen nicht mehr. Ein Verständnis der Natur und Kultur als ein gemeinsames Erbe der Menschheit ist erforderlich. Mit der Herausforderung, die Ziele nachhaltiger Entwicklung zu verwirklichen, entstehen neue Aufgaben, die zugleich neue Grenzziehungen erfordern. Diese führen zu veränderten Einstellungen und Formen von Identität. Dabei nehmen die Auseinandersetzungen mit neu entstehenden Formen des Nationalismus, Kolonialismus und Rassismus zu. Diese Kontroversen wirken sich negativ auf die Entwicklung von Nachhaltigkeit und „Global Citizenship“ aus. In diesen Prozessen entstehen neue Grenzen und Erfahrungen von Alterität.
Grenzen und Entgrenzung der Selbst-Entwicklung im Kontext einer zukunftsfähigen Welt
Authors: Peters Björn 
Published: September 2024

Abstract
Selbst-Entwicklung beschreibt den be- und entgrenzenden Prozess der vertikalen Persönlichkeitsentwicklung im Erwachsenenalter, in dessen Rahmen qualitativ unterscheidbare, messbare Entwicklungsstufen beschrieben werden können. Die in der Gegenwart modalen Stufen in der Bevölkerung sind ebenso wie die in der westlichen Welt als Zielbild angestrebte institutionelle Stufe des Selbst durch inhärente Begrenzungen gekennzeichnet, die sich auch im Umgang mit den globalen Herausforderungen von Gegenwart und Zukunft zeigen. Haltung und Fähigkeiten, die mit späteren, postkonventionellen Stufen der SelbstEntwicklung einhergehen, können hingegen im Umgang mit den Herausforderungen der Postmoderne hilfreich sein.
Mathematics teachers' and student teachers' attitudes towards mathematics teaching in comparison
Authors: Būdienė Virginija 
Published: September 2024

This article deals with the study on attitudes of Lithuanian mathematics teachers and student teachers towards math education. The objective of the study is to determine the level and differences of basic concep­tions of Lithuanian math teachers and students, and to compare with conceptions of Estonian and Finnish mathematics teachers. The research is based upon the typology of concepts introduced by J. Dionne (1984). The common math education culture of teachers and student teachers is discovered. The discussion on revealed similarities and differences is presented.
Genes of Streptomyces globisporus 1912-4Crt Encoding Chitin Catabolism Enzymes
Authors: Polishchuk L.V. 
Published: September 2024

Polysaccharide chitin is one of the most common biopolymers in nature. Chitin (when used as the sole source of energy, carbon, and nitrogen) has been shown to be a substrate sufficient to enable the growth and synthesis of secondary metabolites by the S. griseus NCIMB 8136 strain and some other streptomycetes. The species Streptomyces globisporus and S. griseus belong to the same lower hierarchical taxon (S. griseus clade). The aim was to find in the S. globisporus 1912-4Crt genome genes encoding proteins that are necessary for chitin fermentation and transmembrane transport of resulting products. Methods. The object of the study was a sequence of the S. globisporus 1912-4Crt genome (reference NZ_QWFA01000000.1, GenBank) on the server of NCBI (The National Center for Biotechnology Information). Streptomycete S. globisporus 1912 and its variants are producers of antibiotic landomycin E and carotenoids. Search for and analysis of nucleotide and amino acid sequences were performed using programs BLAST (Basic Local Alignment Search Tool) on the aforementioned server. Results. A set of genes that determine enzymes of chitin catabolism and Ngc-transporter proteins were identified in the S. globisporus 1912-4Crt genome. Genes encoding 10 endo-acting chitinases (from the GH18 and GH19 families) and 2 exo-acting hydrolases (GH20) were identified in the S. globisporus 1912-4Crt sequence. Several genes determining deacetylases that deacetylate both chitin and oligosaccharides were found in the genome of the strain. One gene that determines endo-acting chitosanase from the GH75 family was discovered there. The ability of the wild-type strain S. globisporus 1912 and a number of its variants (including S. globisporus 1912-4Crt) to ferment chitin was proven in vitro. Conclusions. A set of genes sufficient for chitin assimilation was established in the S. globisporus 1912-4Crt genome sequence. Streptomycetes from different clades (for example, strains of S. coelicolor (S. albidoflavus group) and S. griseus, S. globisporus (S. griseus group)) containing different complexes of chitinolytic enzymes could be suggested.