bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Whole Blood Transfusion and Mortality Among Patients With Hemorrhagic Shock and Traumatic Brain Injury
Authors: Aoki Makoto , Katsura Morihiro , Matsushima Kazuhide 
Published: September 2024

BACKGROUND AND OBJECTIVES:
Whole blood (WB) transfusion in trauma has been revisited, and recent studies have reported an association between WB and improved survival among patients with hemorrhagic shock. However, no evidence of a similar association exists for patients with hemorrhagic shock and traumatic brain injury (TBI). This study aimed to assess the association between WB and mortality among patients with hemorrhagic shock and TBI.

METHODS:
This study retrospectively analyzed data obtained from American College of Surgeons-Trauma Quality Improvement Program during January 2020 to December 2021. Patients (age ≥18 years) requiring blood transfusion within 4 hours of hospital arrival and sustaining TBI (head Abbreviated Injury Scale >2) were included. Survival at 30 days were compared after performing 1:1 propensity score matching for demographics, injury type, vital signs on admission, TBI characteristics, injury characteristics, comorbidities, hemorrhage control procedures, hospital characteristics, and withdrawal of life support.

RESULTS:
A total of 15 967 patients were eligible for analysis. The median age was 42 years (interquartile range: 28-60 years); 11 789 (73.8%) patients were male, and 10 102 (63.2%) patients were White. Of them, 2725 (17.0%) received WB. After a 1:1 propensity score matching, 2720 matched pairs were compared. Matched patients had 1.0 as median shock index and 79 mm Hg as the lowest systolic blood pressure requiring immediate transfusion. WB was not associated with reduced 30-day mortality, compared with non-WB (34.0% vs 34.7%, odds ratio: 0.97, 95% confidence interval: 0.87-1.09).

CONCLUSION:
WB was not associated with reduced 30-day mortality among patients with hemorrhagic shock and TBI. These findings suggest that not all patients with hemorrhagic shock would benefit from WB.
Impact of Intracranial Hemorrhage After Endovascular Treatment for Medium Vessel Occlusion
Authors: Fujiwara Satoru , Uchida Kazutaka , Ohta Tsuyoshi , Ohara Nobuyuki , Kawamoto Michi , Yamagami Hiroshi , Hayakawa Mikito , Ishii Akira , Iihara Koji , Imamura Hirotoshi , Matsumaru Yuji , Sakai Chiaki , Satow Tetsu , Yoshimura Shinichi , Sakai Nobuyuki ,   on behalf of the Japanese Registry of Neuroendovascular Therapy (JR-NET) Investigators
Published: September 2024

BACKGROUND AND OBJECTIVES:
Endovascular treatment (EVT) for medium vessel occlusion (MeVO) raises concern about hemorrhagic complications; however, its clinical impact has not been elucidated. Therefore, we investigated the association between intracranial hemorrhage (ICH) after EVT for MeVO and functional outcomes.

METHODS:
We conducted a post hoc analysis of the Japan Registry of NeuroEndovascular Therapy 4, a nationwide registry in Japan from 2015 to 2019 including 13 479 patients who underwent EVT for acute ischemic stroke. This study included 2465 patients with MeVO from 166 participating centers in Japan. We compared patients who underwent EVT for MeVO according to their hemorrhagic complication after EVT (no ICH, asymptomatic ICH, and symptomatic ICH). Outcomes included a modified Rankin scale (mRS) score at 30 days and all-cause mortality within 30 days. We estimated the odds ratios (ORs) and their CIs using a multivariable logistic regression model.

RESULTS:
Among 2394 patients analyzed, 302 (12.6%) developed ICH, with 95 (31.5%) being symptomatic. Compared with the no-ICH group (n = 2092), the asymptomatic and symptomatic ICH groups had a lower proportion of patients with an mRS score of 0 to 2 at 30 days (41% vs 34%, vs 7.4%, P for trend <.001), with an adjusted ORs of 0.77 (95% CI, 0.53-1.12) and 0.12 (95% CI, 0.05-0.30) in the asymptomatic and symptomatic ICH groups, respectively. The adjusted common ORs of one-point shift of mRS score at 30 days in the asymptomatic ICH group was 0.76 (95% CI, 0.57-0.99) and that of the symptomatic ICH group was 0.13 (0.07-0.23), compared with the no-ICH group.

CONCLUSION:
ICH after EVT for MeVO was associated with worse outcomes, whether they were symptomatic or not. The optimal treatment devices or techniques to reduce ICH after EVT for MeVO are crucial.
Dose-dependent responses to canonical Wnt transcriptional complexes in the regulation of mammalian nephron progenitors
Authors: Bugacov Helena , Der Balint , Briantseva Bohdana-Myroslava , Guo Qiuyu , Kim Sunghyun , Lindström Nils O. , McMahon Andrew P. 
Published: September 2024

ABSTRACT
In vivo and in vitro studies argue that concentration-dependent Wnt signaling regulates mammalian nephron progenitor cell (NPC) programs. Canonical Wnt signaling is regulated through the stabilization of β-catenin, a transcriptional co-activator when complexed with Lef/Tcf DNA-binding partners. Using the GSK3β inhibitor CHIR99021 (CHIR) to block GSK3β-dependent destruction of β-catenin, we examined dose-dependent responses to β-catenin in mouse NPCs, using mRNA transduction to modify gene expression. Low CHIR-dependent proliferation of NPCs was blocked on β-catenin removal, with evidence of NPCs arresting at the G2-M transition. While NPC identity was maintained following β-catenin removal, mRNA-seq identified low CHIR and β-catenin dependent genes. High CHIR activated nephrogenesis. Nephrogenic programming was dependent on Lef/Tcf factors and β-catenin transcriptional activity. Molecular and cellular features of early nephrogenesis were driven in the absence of CHIR by a mutated stabilized form of β-catenin. Chromatin association studies indicate low and high CHIR response genes are likely direct targets of canonical Wnt transcriptional complexes. Together, these studies provide evidence for concentration-dependent Wnt signaling in the regulation of NPCs and provide new insight into Wnt targets initiating mammalian nephrogenesis.
Developmental programming of sarcoplasmic reticulum function improves cardiac anoxia tolerance in turtles
Authors: Ruhr Ilan M. , Shiels Holly A. , Crossley Dane A. , Galli Gina L. J. 
Published: September 2024

ABSTRACT
Oxygen deprivation during embryonic development can permanently remodel the vertebrate heart, often causing cardiovascular abnormalities in adulthood. While this phenomenon is mostly damaging, recent evidence suggests developmental hypoxia produces stress-tolerant phenotypes in some ectothermic vertebrates. Embryonic common snapping turtles (Chelydra serpentina) subjected to chronic hypoxia display improved cardiac anoxia tolerance after hatching, which is associated with altered Ca2+ homeostasis in heart cells (cardiomyocytes). Here, we examined the possibility that changes in Ca2+ cycling, through the sarcoplasmic reticulum (SR), underlie the developmentally programmed cardiac phenotype of snapping turtles. We investigated this hypothesis by isolating cardiomyocytes from juvenile turtles that developed in either normoxia (21% O2; ‘N21’) or chronic hypoxia (10% O2; ‘H10’) and subjected the cells to anoxia/reoxygenation, in either the presence or absence of SR Ca2+-cycling inhibitors. We simultaneously measured cellular shortening, intracellular Ca2+ concentration ([Ca2+]i), and intracellular pH (pHi). Under normoxic conditions, N21 and H10 cardiomyocytes shortened equally, but H10 Ca2+ transients (Δ[Ca2+]i) were twofold smaller than those of N21 cells, and SR inhibition only decreased N21 shortening and Δ[Ca2+]i. Anoxia subsequently depressed shortening, Δ[Ca2+]i and pHi in control N21 and H10 cardiomyocytes, yet H10 shortening and Δ[Ca2+]i recovered to pre-anoxic levels, partly due to enhanced myofilament Ca2+ sensitivity. SR blockade abolished the recovery of anoxic H10 cardiomyocytes and potentiated decreases in shortening, Δ[Ca2+]i and pHi. Our novel results provide the first evidence of developmental programming of SR function and demonstrate that developmental hypoxia confers a long-lasting, superior anoxia-tolerant cardiac phenotype in snapping turtles, by modifying SR function and enhancing myofilament Ca2+ sensitivity.
Application-Driven Learning: A Closed-Loop Prediction and Optimization Approach Applied to Dynamic Reserves and Demand Forecasting
Authors: Dias Garcia Joaquim , Street Alexandre , Homem-de-Mello Tito , Muñoz Francisco D. 
Published: September 2024

Application-Driven Learning: Closing the Loop Between the Application and the Estimation of Forecast Models This paper introduces a closed-loop framework called application-driven learning, where the best forecast model is tailored to the application cost structure. Our methodology employs two-stage optimization schemes to derive multivariate point forecasts. The estimation problem is conceived as a bilevel model, and we propose two solution methodologies: an exact one using KKT conditions and a scalable decomposition heuristic. This approach offers a scientifically grounded alternative to ad hoc demand biasing approaches and reserve requirement rules currently adopted by power system operators worldwide. Testing with real data and large-scale systems demonstrates that our methodology consistently outperforms traditional open-loop methods, providing significant potential benefits for energy system operations.
Management After Obstetric Anal Sphincter Injury: Anorectal Manometry and Symptoms Predict Long-Term Fecal Incontinence
Authors: Trieu Rose Qizhengyan , Mazor Yoav , Verdon Christine , Jones Michael , Ejova Anastasia , Burton Gil , Schnitzler Margaret , Malcolm Allison 
Published: September 2024

INTRODUCTION:
Obstetric anal sphincter injury (OASI) is associated with serious morbidity and reduced quality of life. The role of anorectal manometry (ARM) to guide treatment is unclear. We aimed to define the role of ARM and symptom assessment after OASI in predicting anal incontinence at long-term follow-up.

METHODS:
Prospective evaluation of 205 consecutive post-OASI women who underwent baseline ARM and symptom assessment in a tertiary setting was undertaken. Ninety-nine women were available for long-term follow-up (median 6.6 years). Associations between post-OASI ARM testing and short-term and long-term anal incontinence were examined in addition to clinical and obstetric factors.

RESULTS:
Fourth degree tears and lower anal resting and squeeze pressures were associated with short-term anal incontinence. Women with anal incontinence at baseline and women with lower anal resting pressure were more likely to suffer from long-term fecal incontinence (FI). A best-fit cutoff value of 59 mm Hg for baseline anal resting pressure predicted long-term FI, and none of the short-term asymptomatic women with an anal resting pressure of >59 mm Hg reported FI at long-term follow-up.

DISCUSSION:
Symptoms of anal incontinence and ARM in patients after OASI are both useful to predict subsequent long-term FI with a best-fit cutoff of 59 mm Hg for anal resting pressure. This provides rationale for routine ARM and accurate symptom assessment in all patients after OASI, to identify high-risk groups to follow and treat, and it may assist decision making regarding mode of subsequent obstetric deliveries.
TC-325 Superiority in Malignant Gastrointestinal Bleeding: An Individual Patient Data Meta-Analysis of Randomized Trials
Authors: Alali Ali A. , Pittayanon Rapat , Martel Myriam , Martins Bruno Costa , Almadi Majid A. , Chen Yen-I , Barkun Alan N. 
Published: September 2024

INTRODUCTION:
The efficacy of topical hemostatic agents, recommended for peptic ulcer bleeding, remains poorly characterized in malignant gastrointestinal bleeding (GIB).

METHODS:
We performed an individual patient data meta-analysis assessing the efficacy of topical hemostatic agents in malignant GIB. The literature was searched using OVID MEDLINE, EMBASE, and ISI Web of Science databases (database inception to November 2023). Only randomized controlled trials (RCTs) comparing topical hemostatic agents with conventional endoscopic modalities in malignant GIB were included. Original RCT patient-level data were obtained. Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines were followed. Quality of the evidence was evaluated using the revised Cochrane risk-of-bias tool and certainty of evidence with the Grading of Recommendations Assessment, Development, and Evaluation approach. The primary outcome was immediate hemostasis; secondary outcomes were 30-day rebleeding and the composite measure of further bleeding (persistent bleeding or 30-day rebleeding). Other outcomes were all-cause mortality, adverse events, and need for additional nonendoscopic treatment. Odds ratios (ORs) from endpoint comparisons were pooled using logistic regression models.

RESULTS:
Overall, 985 citations were identified; 3 RCTs (n = 160 patients) were included with all assessing TC-325 (Hemospray). TC-325 achieved immediate hemostasis more often than conventional endoscopic modalities (OR 46.6, 95% confidence interval [CI] 5.89–369.1) (low-level certainty). Thirty-day rebleeding (OR 0.28, 95% CI 0.11–0.70) and further bleeding (OR 0.11, 95% CI 0.05–0.26) were both significantly lower with TC-325 (very-low-level certainty). All-cause mortality and need for additional nonendoscopic treatment did not differ between groups. No adverse events were reported. Subgroup analysis confirmed TC-325 superiority in patients with upper GIB.

DISCUSSION:
TC-325 seems superior to conventional endoscopic therapy in managing patients with malignant GIB. TC-325 results in improvements in immediate hemostasis, 30-day rebleeding, and further bleeding, based on very low-to-low certainties of evidence.
Needle Knife Stricturoplasty for Hepaticojejunostomy Stricture After Whipple Procedure
Authors: Mirminachi Seyedbabak , Slivka Adam , Mahmood Sultan 
Published: September 2024

ABSTRACT
Hepaticojejunostomy anastomotic stricture is a relatively uncommon postoperative complication after a Whipple procedure. However, they are increasingly being observed because of advancements in operative mortality rates and the widening of operative indications to include benign diseases such as chronic pancreatitis and intraductal papillary mucinous neoplasm. In this article, we describe a patient diagnosed with intraductal papillary mucinous neoplasm and another with pancreatic cancer, both of whom developed jaundice after undergoing the Whipple procedure. Subsequent investigation revealed a benign hepaticojejunostomy anastomotic stricture, successfully treated with stricturoplasty using a needle knife.
Unveiling a Sour Truth: Acute Pancreatitis Linked to Apple Cider Vinegar Supplement
Authors: Alvarez Luis , Colaco Lanson B. , Ali Saba , Jabbal Iktej S. Singh , Banga Veerkaran , Avalos Martin A. , Patel Pankaj J. 
Published: September 2024

ABSTRACT
Acute pancreatitis, a common gastrointestinal ailment in the United States, often lacks a clear etiology, with one-third of cases deemed idiopathic. We discuss an 84-year-old woman with acute pancreatitis possibly linked to a recently introduced weight loss supplement containing apple cider vinegar. Literature review unveils scant data regarding the risks of acute pancreatitis associated with less rigorously studied and regulated supplements, such as apple cider vinegar products. Considering the morbidity and financial burden associated with acute pancreatitis, there is a pressing need to report and disseminate awareness of diverse etiologies, encompassing drug and supplement-induced cases. This case report endeavors to address this need.
El arresto domiciliario con monitoreo electrónico
Authors: Pardini Agustín 
Published: September 2024

El uso del arresto domiciliario con monitoreo electrónico (ADME) se ha extendido por todo el mundo, incluso en la República Argentina. Sin embargo, al margen de la literatura producida en el Norte Global, no hay ninguna investigación sobre el modo en que las personas penadas perciben la punitividad de esta sanción en nuestro país y son muy escasas las realizadas en el resto del mundo de habla hispana. Este trabajo se propone comenzar a rellenar ese vacío, con un estudio exploratorio sobre las percepciones de los usuarios del sistema penal en la Ciudad de Buenos Aires. Los resultados muestran que la preferencia del ADME frente a la prisión es igual o más pronunciada que en investigaciones del mundo anglosajón y Europa. El «marco de la alternativa preferida» respecto de la prisión y las deplorables condiciones carcelarias podrían estar incidiendo en ello. El rol de la pareja y los hijos tampoco puede soslayarse. Contrario a previos trabajos, el género femenino parece moderar negativamente la sujeción que genera esta penalidad alternativa. Consciente de las limitaciones del tamaño de la muestra, esta primera exploración permite orientar futuras investigaciones del contexto argentino y el resto del mundo, e informar la política criminal y legislativa.
gobiernos locales ante el desafío de conocer las estructuras socio-productivas de su localidad y su dinámica
Authors: Barletta María Alicia , Giménez Puentes María Pía , Olivares Pablo 
Published: September 2024

La presente investigación–acción se enmarca en el desarrollo de un Programa Específico deFortalecimiento para la investigación en Ciencias Económicas (PROMCE) denominado «El perfil socioproductivo de la ciudad de Venado Tuerto y su impacto presupuestario en el marco del desarrollo del Plan Estratégico Local», la misma se fundamentó en la necesidad de vinculación de la academia con la gestión pública a los fines de generar un sistema de indicadores socioeconómicos queperm itan evaluar, monitorear y controlar el desenvolvimiento local, diseñando el perfil socioproductivo de Venado Tuerto en el marco del Plan de Desarrollo Estratégico llevado a cabo por el Municipio. El trabajo realizado reviste carácter de inédito ya que hasta el momento no se contaba con dicho instrumentoen el gobierno local. El equipo de la Facultad de Ciencias Económicas de la Universidad Nacional del Litoral construye esta propuesta que contiene componentes de investigación, aplicación profesional, formación académica y transferencia al medio. Es de señalar que, el impacto de la misma no solo debeconsiderarse para el caso concreto ya que es factible replicar la experiencia en otros ámbitos de gobiernos locales.
ANALISIS SEBARAN RUANG TERBUKA HIJAU (RTH) PUBLIK MENGGUNAKAN METODE SISTEM INFORMASI GEOGRAFIS (SIG) DI KABUPATEN SIDOARJO
Authors: Azra Ahmad Azyumardi 
Published: September 2024

Parameter uji yang digunakan dalam penelitian ini adalah perhitungan kebutuhan ruang terbuka hijau berdasarkan luas wilayah Kabupaten Sidoarjo. Tujuan penelitian ini melakukan identifikasi lokasi ruang terbuka hijau (RTH) publik di wilayah kabupaten Sidoarjo, mengetahui ketersediaan ruang terbuka hijau publik di Kabupaten Sidoarjo menggunakan metode sistem informasi geografis (SIG), mengetahui seberapa besar kebutuhan ruang terbuka hijau (RTH) publik di Kabupaten Sidoarjo, mengevaluasi ruang terbuka hijau publik di Kabupaten Sidoarjo sudah memenuhi atau belum berdasarkan Permen ATR/BPN No. 14 Tahun 2022. Metode yang digunakan penelitian ini dilakukan dengan metode kuantitatif dan deskriptif. Pada metode kuantitatif dilakukan perhitungan berupa kebutuhan RTH publik berdasarkan luas wilayah. Hasil penelitian menunjukkan bahwa Kabupaten Sidoarjo memiliki 3 jenis ruang terbuka hijau (RTH) publik, yaitu taman kabupaten memiliki taman kabupaten memiliki total 22 titik yang tersebar 4 kecamatan di Kabupaten Sidoarjo dengan luas 71.082,65 m2, jenis pemakaman memiliki total 20 titik yang tersebar di 5 kecamatan dengan luas 31.561,46 m2, dan jenis jalur hijau memiliki total 13 titik yang tersebar di 4 kecamatan dengan luas 6.146,9 m2. Kebutuhan RTH Kabupaten Sidoarjo di bagian kawasan perkotaan Kabupaten Sidoarjo yaitu 45.702,97 m2 jika dilihat dari 20% luas wilayah Kabupaten Sidoarjo kawasan perkotaan yaitu 223.213 m2. Hal ini menunjukkan bahwa RTH publik di Kabupaten Sidoarjo sudah memenuhi sesuai Peraturan Pemerintah Badan Pertanahan Nasional (BPN) no 14 tahun 2022.
Influence of foot strike pattern on co‐contraction around the ankle and oxygen uptake during running at 19 km/h
Authors: Kubo Shimpei , Yaeshima Katsutoshi , Suzuki Takahito , Daigo Eiji , Kitaoka Yu , Kinugasa Ryuta 
Published: September 2024

AbstractThis study investigated the coactivation of plantar flexor and dorsiflexor muscles and oxygen uptake during running with forefoot and rearfoot strikes at 15 and 19 km/h. We included 16 male runners in this study. The participants ran each foot strike pattern for 5 min at 15 and 19 km/h on a treadmill. During the running, respiratory gas exchange data and surface electromyographic (EMG) activity of the medial gastrocnemius (MG), lateral gastrocnemius (LG), soleus, and tibialis anterior muscles of the right lower limb were continuously recorded. The indices of oxygen uptake, energy expenditure (EE), and muscle activation were calculated during the last 2 min in each condition. During the stance phase of running at 15 and 19 km/h, activation of the tibialis anterior and MG muscles was lower and higher, respectively, with forefoot strike than with rearfoot strike. The foot strike pattern did not influence the oxygen uptake. These results suggest that the foot strike pattern has no clear effect on the oxygen uptake when running at 15 and 19 km/h. However, forefoot strike leads to plantar flexion dominance during co‐contraction of the tibialis anterior and MG muscles, which are an antagonist and agonist for plantar flexion, respectively, during the stance phase.
Insights into the interaction between time and reward prediction on the activity of striatal tonically active neurons: A pilot study in rhesus monkeys
Authors: Martel A. C. , Apicella P. 
Published: September 2024

AbstractPrior studies have documented the role of the striatum and its dopaminergic input in time processing, but the contribution of local striatal cholinergic innervation has not been specifically investigated. To address this issue, we recorded the activity of tonically active neurons (TANs), thought to be cholinergic interneurons in the striatum, in two male macaques performing self‐initiated movements after specified intervals in the seconds range have elapsed. The behavioral data showed that movement timing was adjusted according to the temporal requirements. About one‐third of all recorded TANs displayed brief depressions in firing in response to the cue that indicates the interval duration, and the strength of these modulations was, in some instances, related to the timing of movement. The rewarding outcome of actions also impacted TAN activity, as reflected by stronger responses to the cue paralleled by weaker responses to reward when monkeys performed correctly timed movements over consecutive trials. It therefore appears that TAN responses may act as a start signal for keeping track of time and reward prediction could be incorporated in this signaling function. We conclude that the role of the striatal cholinergic TAN system in time processing is embedded in predicting rewarding outcomes during timing behavior.
Laryngeal non-Hodgkin lymphoma: Report of four cases and review of the literature
Authors: Tang Xin , Wang Dingting , Feng Huajun , Qin Gang 
Published: September 2024

Abstract
Non-Hodgkin lymphoma (NHL) limited to the larynx is very rare. The authors present the clinical diagnosis and treatment of four patients with laryngeal NHL. Case 1 was diagnosed with glottic, subglottic, and tracheal mucosa-associated lymphoid tissue (MALT) lymphoma, and was treated with radiotherapy and chemotherapy after surgery. Case 2 was diagnosed with laryngeal MALT lymphoma and underwent radiotherapy. Case 3 was diagnosed with angioimmunoblastic T-cell lymphoma, and was treated with radiotherapy and chemotherapy. Case 4 had MALT lymphoma in the glottic area with a malignant thyroid tumor, and was treated with radiotherapy and chemotherapy after surgery. More reports and research on this disease are needed.