bluuebunny/crossref_metadata_2025_split huggingface dataset:
FVIII-binding IgG modulates FVIII half-life in patients with severe and moderate hemophilia A without inhibitors
Authors: Hofbauer Christoph J. , Kepa Sylvia , Schemper Michael , Quehenberger Peter , Reitter-Pfoertner Sylvia , Mannhalter Christine , Reipert Birgit M. , Pabinger Ingrid 
Published: May 2016

Key Points
FVIII-specific IgG antibodies modulate FVIII half-life in patients with hemophilia A, independent of VWF antigen levels and age. Screening for FVIII-specific IgG may be beneficial in tailoring FVIII prophylactic regimens for hemophilia A patients.
Europe – from common market to political union
Authors: Simonis Heide 
Published: May 2016

AbstractsThis article is about the evolution of Europe after the Second World War from a Union for coal and steel to a common market and a political union, the European Union with a common currency – the Euro. The ups and down of the process of economic and social integration are addressed, as well as the possible ways towards the future. This future could either mean a new treaty from above or a better founding from the bottom. The Nobel Peace Prize for the European Union is supposed to be a burden but also a stimulus for further political integration and sustainable development.Dieser Artikel behandelt die Europas nach dem Zweiten Weltkrieg von einer Gemeinschaft für Kohle und Stahl zu einem gemeinsamen Markt und einer politischen Union mit einer gemeinsamen Währung – dem Euro. Die Aufs und Abs der ökonomischen und sozialen Integration werden angesprochen, ebenso wie die möglichen Wege in die Zukunft. Die Zukunft könnte entweder einen neuen Vertrag von oben oder besser eine Grundlegung von unten bedeuten. Der Friedensnobelpreis für die Europäische Union mag sowohl eine Bürde aber auch eine Ermunterung für weitere politische Integration sowie nachhaltige Entwicklung sein.
Brazilian Society for Food and Nutrition position statement: gluten-free diet
Authors: Pantaleão Lucas Carminatti , Rogero Marcelo Macedo , Amancio Olga Maria Silverio 
Published: May 2016

AbstractPosition statement: The Brazilian Society for Food and Nutrition (SBAN) bases the following position statement on a critical analysis of the literature on the indications of a gluten-free (GF) diet. (1) There is insufficient evidence to assume that healthy individuals would experience any benefits from the consumption of a GF diet. (2) Recent studies suggest that gluten sensitivity may be confounded by sensitivity to low-fermentable, poorly absorbed, short-chain carbohydrates known as fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs). (3) Epidemiological data supports that even overweight celiac disease (CD) individuals fail to achieve weight loss under a GF diet. (4) Recent experimental data showed possible deleterious effects of GF feeding on the intestinal microbiota of healthy individuals. (5) GF diets can be healthy for the general population, as long as GF-processed foods are avoided, and the ingestion of other whole grains, and low-energy-density vegetables is assured. This position statement has been externally reviewed and approved by the board of the Brazilian Society for Food and Nutrition, and has not gone through the journal’s standard peer review process.
Prognostic Impact of the Combination of Recurrence Score and Quantitative Estrogen Receptor Expression (ESR1) on Predicting Late Distant Recurrence Risk in Estrogen Receptor–Positive Breast Cancer After 5 Years of Tamoxifen: Results From NRG Oncology/National Surgical Adjuvant Breast and Bowel Project B-28 and B-14
Authors: Wolmark Norman , Mamounas Eleftherios P. , Baehner Frederick L. , Butler Steven M. , Tang Gong , Jamshidian Farid , Sing Amy P. , Shak Steven , Paik Soonmyung 
Published: May 2016

Purpose We determined the utility of the 21-Gene Recurrence Score (RS) in predicting late (> 5 years) distant recurrence (LDR) in stage I and II breast cancer within high and low-ESR1–expressing groups. Patients and Methods RS was assessed in chemotherapy/tamoxifen-treated, estrogen receptor (ER) –positive, node-positive National Surgical Adjuvant Breast and Bowel Project B-28 patients and tamoxifen-treated, ER-positive, node-negative B-14 patients. The association of the RS with risk of distant recurrence (DR) 0 to 5 years and those at risk > 5 years was assessed. An ESR1 expression cut point was optimized in B-28 and tested in B-14. Results Median follow-up was 11.2 years for B-28 and 13.9 years for B-14. Of 1,065 B-28 patients, 36% had low (< 18), 34% intermediate (18 to 30), and 30% high (≥ 31) RS. Of 668 B-14 patients, 51% had low, 22% intermediate, and 27% high RS. Median ESR1 expression by reverse transcriptase polymerase chain reaction was: B-28, 9.7 normalized expression cycle threshold units (CT) and B-14, 10.7 CT. In B-28, RS was associated with DR 0 to 5 years (log-rank P < .001) and > 5 to 10 years (log-rank P = .02) regardless of ESR1 expression. An ESR1 expression cut point of 9.1 CT was identified in B-28. It was validated in B-14 patients for whom the RS was associated with DR in years 5 to 15: 6.8% (95% CI, 4.4% to 10.6%) versus 11.2% (95% CI, 6.2% to 19.9%) versus 16.4% (95% CI, 10.2% to 25.7%) for RS < 18, RS 18 to 30, and RS ≥ 31, respectively (log-rank P = .01). Conclusion For LDR, RS is strongly prognostic in patients with higher quantitative ESR1. Risk of LDR is relatively low for patients with low RS. These results suggest the value of extended tamoxifen therapy merits evaluation in patients with intermediate and high RS with higher ESR1 expression at initial diagnosis.
Pleospdione, A Tricyclic Natural Product with Dense Oxygenation at the A-Ring: Total Synthesis and Incongruity of the Originally Assigned Structure and its C3-Epimer
Authors: Takikawa Hiroshi , Ishikawa Yui , Yoshinaga Yuki , Hashimoto Yoshimitsu , Kusumi Takenori , Suzuki Keisuke 
Published: May 2016

Abstract
Previously we developed a promising synthetic approach to complex polycyclic natural products, including aromatic polyketides derived from the type-II polyketide biosynthesis. The approach consists of three key steps; (1) cycloaddition or cyclocondensation of nitrile oxide for assembling the carbon skeleton having an isoxazole as a 1,3-diketone equivalent, (2) benzoin cyclization for stereoselective ring fusion with an angular hydroxy group, and (3) oxidation of isoxazolium salt for installing an additional angular hydroxy group in stereoselective manner. As a synthetic exercise to highlight the utility of this approach, the first total syntheses of the proposed structure of pleospdione (1) and its C3-epimer (3-epi-1) have been achieved. The synthesis has proved the efficiency of the strategy as an entry into polyketide-derived complex architectures. At the same time, it was revealed that neither 1 nor 3-epi-1 represent the true structure of the natural product by incongruity of the NMR spectra.
Quality Monitoring of Delivery of Physical Services for the Different Student Body
Authors: ��������  , Kudinova Viktoriya 
Published: May 2016

In this study, the physical exercises were considered from the standpoint of ensuring the quality of sports and sports services that require substantial
changes in the content of educational and training process. Of the greatest importance for students of secondary schools at physical training lessons
were indicators of interaction with teachers, for pupils of high-school and lyceum students � the characteristics of the performance and reliability of the
learning process. Students of secondary schools, who exercise in the sports sections, mark off the indicators of duration of training and self-study, and
lyceum students and pupils of high-school are more focused on the choice of training facilities and the duration of the training sessions. The requirements
of involved in Youth Sports School students primarily related to enhancing the effi ciency of the training process.
Comparison of generalized indices of quality of fi tness and sports services of the diff erent school enrolment showed marked features of competitiveness:
the older the students, the more requirements are placed on the quality of physical culture and sports services. The degree of satisfaction of physical culture
and sports services provided by secondary schools and further education institutions, were signifi cantly diff erent in levels of claims of students. This
discrepancy of indices indicated that teachers were trying to attract students to physical culture and sports mainly through coercion.
Quadricuspid Aortic Valve Combined with Moderate Ascending Aortic Dilatation
Authors: Uspenskiy Vladimir , Osadchii Alexei , Gordeev Mikhail 
Published: May 2016

AbstractThe quadricuspid aortic valve is a very uncommon malformation associated with aortic insufficiency, aortic stenosis, endocarditis, and ascending aortic dilatation. We report four cases of this aortic valve malformation. One patient with severe aortic regurgitation and moderate aortic dilatation required aortic valve replacement. Three patients had mild or moderate aortic insufficiency combined with moderate ascending aortic dilatation. These patients were referred to follow-up. The presented cases demonstrate that this aortic valve malformation may not be as rare as it appears and that attention must be paid to any quadricuspid findings during computed tomographic angiography and echocardiography.
Principles for Management of Intraoperative Acute Type A Aortic Dissection
Authors: Gukop Philemon , Chandrasekaran Vankatachalam 
Published: May 2016

AbstractIntraoperative Type A aortic dissection is a rare pathology with incidence of 0.06–0.32%. It is associated with a high mortality between 30–50%. Some associated risk factors, including hypertension, enlarged aorta, peripheral vascular disease, advanced age, atheroma, and high arterial pressure on cardiopulmonary bypass, have been identified. Modification of these risk factors could reduce the incidence of this event. Prompt diagnosis and management, with the aid of intraoperative trans-esophageal echocardiography and/or epi-aortic ultrasound has been shown to reduce the mortality to 17%. We illustrate the principles of management of this pathology with the case of a 62-year-old female who developed acute Type A aortic dissection while undergoing minimally invasive mitral valve repair.
Identifikasi Bidang Gelincir Pemicu Bencana Tanah Longsor Dengan Metode Resistivitas 2 Dimensi Di Desa Pablengan Kecamatan Matesih Kabupaten Karanganyar
Authors: D Darsono , Nurlaksito Bambang , Legowo Budi 
Published: May 2016

<span>Investigation of landslide slip surface has been conducted at Salaman Sub village, <span>Pablengan Village, Matesih District, Karanganyar Regency, Central Java Province by using <span>dipole-dipole array geoelectrical resistivity method. Data processing were using Res2Dinv <span>version 3.45 (semi demo version) software. The interpretation result showed that at the <span>research area was found lithology consist i.e. clay, wet clay, sandy clay until claysand, sand <span>until breccia. The slip surface is a wet clay layer with resistivity value range from 19.3 Ω m <span>to 36.6 Ω m, for one section was found with depth of 1.7 meter until 17 meters, and for two <span>section was found with depth of 8.9 until 16.4 meters.</span></span></span></span></span></span></span><br /></span>
Penentuan Tingkat Kekerasan Batuan Menggunakan Metode Seismik Refraksi di Jatikuwung Karanganyar
Authors: Nurcandra Nakif , D Darsono , Koesuma Sorja 
Published: May 2016

<span>It has been done a research about the determination of rock hardness level by using refraction <span>seismic method in Jatikuwung Karanganyar. The research is done by using <span><em>Seismograph PASI </em><span><em>16S24-P </em><span>with the path length of 48 meters, distance between <span><em>geophone </em><span>2 meters, 5 <span><em>shots </em><span>in <span>each spread and there are four surveys part totally. The processing data is done by using <span>SeisImager software with <span><em>Plotrefa </em><span>and <span><em>Pickwin95 </em><span>program.We use <span><em>intercept time </em><span>method for <span>data processing. The determination of rock hardness use <span><em>Gardner’s relationship </em><span>formula. <span>Based on interpretation, there are three layers lithology structure with P wave propagation <span>velocity of 200-1800 m/s and its density of 1.17<span>–<span>1.93 gr/cc. Based on velocity analysis we <span>determine the velocity of first layer is 200-700 m/s, second layer 700-1500 m/s, and third <span>layer 1500-1800 m/s. The subsurface hardness lithology consists of <span><em>top soil</em><span>, sands and <span>unsaturated pebble (1.17<span>–<span>1.59 gr/cc) with the depth 2<span>–<span>4 meters in the first layer, saturated<br /><span>sands, saturated pebble, and alluvium (1.59<span>–<span>1.93 gr/cc) with the depth 9.5<span>–<span>11.5 meters in the <span>second layer, and clay and sands (1.93<span>–<span>2.02 gr/cc) with the depth of 5.5<span>–<span>6 meters in the third <span>layer. The rock hardness is located at the depth betwen 12 <span>– <span>20 meters.</span></span></span></span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span>
Kajian Pengaruh Penambahan Nanopartikel Perak (AgNPs) Terhadap Respon Instrumen Sensing Berbasis Surface Plasmon Resonance (SPR)
Authors: Arifani Tyas , Abraha Kamsul 
Published: May 2016

<span>Theoretical studies have been done related to the phenomenon of surface plasmon resonance <span>(SPR) on the system with addition of silver nanoparticles (AgNPs) that was modeled as a <span>sensing instrument. Model is built with AgNPs placed as an additional layer over the <span>conventional SPR system. Quantitative analysis on the model will provide a response in the <span>form of reflectance spectrum as a function of incident angle that showed SPR angle (<span> <span><em>SPR </em><span>) <span>point and the attenuation. To know how the AgNPs in various sizes affect the resonance <span>coupling, it will be calculated the dispersion relation curves obtained as the solution of <span>M<span>axwell’s equations. Coupling between surface plasmon wave and evanescent wave will <span>provide the resonance angle on the intersection of the two curves. Computational analysis of <span>ATR method, demonstrate how the addition of AgNPs in sensing instrument configuration will <span>improve performance of such instruments, visualized by SPR angle shift.</span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span>
Desain Sensor Serat Optik Sederhana untuk Mengukur Konsentrasi Larutan Gula dan Garam Berbasis Pemantulan dengan Menggunakan Konfigurasi Jarak Cermin-Fiber Optik Tetap
Authors: M Arrini Nurul , Marzuki Ahmad , Yunianto Mohtar 
Published: May 2016

<span>A simple method to measure a solution refractive index using fixed mirror refractive optical <span>fiber sensor has been investigated. The solution used are sugar and salt solution, with concen<span>tration varies from 1M to 5M. The diameter of polymer optical fiber used is 0.5 mm and light <span>source used is LED (λ=676 nm). The sensor work based on light intensity modulation, sub <span>jected to mechanical structure change of the fiber due to an applied force. The result showed <span>that the concentration of sugar and salt linearly are related with their refractive indeces <span>(R<span>2<span>=0,95006) and (R<span>2<span>=0,99858).</span></span></span></span></span></span><br /></span></span></span></span></span>
Sintesa Titanium dioxide (TiO2) untuk Dye-Sensitized Solar Cell dengan Antosianin Bunga Rosella (Hibiscus sabdariffa)
Authors: Adhitya Elsa Ayu , Ramelan Ari Handono , S Suharyana 
Published: May 2016

<span>Synthesis of <span><em>titanium dioxide </em><span>(TiO<span>2<span>) for dye sensitized solar cell (DSSC) with anthocyanins <span>rosella (<span><em>Hibisccus Sabdariffa</em><span>) has succesfully been done using sol-gel technique. The <span>semiconductor layer is a very important part of the DSSC since it gives a high surface area for <span>dye absorption which gives rise to high currents. DSSC was formed structually two electrodes <span>sandwiching the electrolyte. The working electrode is TiO<span>2 <span>layer coating on a Fluorine doped <span>Tin Oxide (FTO) glass substrat and sensitified with anthocyanin dye. A counter electrode is <span>carbon coating on the FTO. The fabricated solar cells have an area of 1.5 cm<span>2<span>, soaked in the <span>anthocyanin dye for 24 hours and 48 hours. The sample was characteriz with X-ray diffraction <span>method. The X-ray diffractogram indicates that the sample possesses rutile and anatase phase. <span>The dye absorption measured using spektrofotometer UV-Visible Lambda 25 showed the<br /><span>absorption occurs in the range 440-620 nm. The efficiencies of the solar cells measured by I-V <span>meter Keithley for 24 and 48 hours soaking are 0.0064(6)%, and 0.0151(4)%, respectively.</span></span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span></span></span></span></span></span></span>
Pengaruh Penggunaan Binder terhadap Densitas dan Kalor Pembakaran Briket dari Limbah Sagu
Authors: Widiyandari Hendri , Setiabudi Wahyu , Subagio Agus , Haryanti Sri , Siahaan Parsaoran , Tjahjana Heru 
Published: May 2016

<span>Biomass fuel such as briquette is one of an alternative energy regarded to the shortage of the <span>fosil fuel and rising its prices. The byproduct of sago starch industry is the waste that remain <span>the environmental problem because of the odor. However this agricultur waste such as trunk <span>cortex and fibre has a potential application as a raw material for briquette.The fibre and trunk <span>cortex act as matrix material of briquette. The utilizing of sago waste as a biomass briquette <span>and the effect of ratio of matrix/binder to the density, time of compustion and gross heat of <span>the briquette have been elucidated sistematically. The analyzing of gross heat using adiabatic <span>calorimetry indicated that the briquette prepared with the ratio of binder/matrix of 3:4 (mass <span>ratio) had the maximum value of 3929.5 kal/g. The duration of combusion was proposional <span>with density of the briquette.</span></span></span></span></span></span></span></span></span><br /></span>
Deteksi Formalin Menggunakan Surface Plasmon Resonance (SPR) Berbasis Nanopartikel Perak sebagai Pengembangan Awal Teknologi Food Safety
Authors: Anam Muhammad Khoirul , Narindra Risma , T Thoyibi , Abraha Kamsul 
Published: May 2016

<span>The phenomena of surface plasmon resonance (SPR) has been observed. SPR is reflectance <span>curve as a function of incident angle in Kretschmann configuration. Surface plasmon is elec<span>tromagnetic waves propagation in the interface area between metal and dielectric that can be <span>excited by using attenuated total reflection (ATR) method. The result of experiment explains <span>that the SPR angle on the thin film system of the prism/silver 1 and the prism/silver 2 is (42.8<br /><span>± 0,05)º with the reflectance value 0.32 and 0.44 respectively. On the prism/silver/silver <span>nanoparticle system, it is obtained that SPR angle value is (4,29 ± 0,05) with the reflectance <span>value 0.29 for the silver 1 and 0.31 for the silver 2. After the thin film system is added with <span>40% of formalin, SPR angle becomes (43,0 ± 0,05)º with the reflectance value 0.44. Then, af<span>ter the thin film system is added with 100% of formalin, SPR angle becomes (43,2 ± 0,05)º<br /><span>with the reflectance value 0.4. The shifting SPR angle shows that SPR have capability as <span>formalin sensor.</span></span></span></span></span></span></span></span></span></span></span><br /></span>
Wind on the fog: A reflection on the policy of historical memory at Televisió de Catalunya through the documentary Perseguits i salvats
Authors: Castelló Enric , Romano María José 
Published: May 2016

Abstract
Identity and collective memory are two sides of the same coin: both are constructed from a narrative of community that may either define the present (identity) or explain the past (memory). These constructs also feed into one another, since memory is built through a consciousness of identity, while identity is the product of our capacity to create and retain a narrative that explains who we are today. This article offers a reflection on the policy of historical memory adopted by the Catalan public broadcasting network Televisió de Catalunya (TVC) and a detailed study of the documentary Perseguits i salvats. Camins de nit i boira/Persecuted and Saved. Paths through the Night and Fog (Solé, 2014). The authors identify the elements that place the documentary within this policy framework, examining its discourse and finding in it three primary goals: to situate the memory of the Catalan people in the context of European memory; to convey the repression of the Spanish Civil War and the ensuing dictatorship to an international audience; and to bear witness to the responsibility of the Franco regime in the events of the Holocaust and the Nazi atrocities.
Writing on the screen as scribing reality: Nineteenth-century moving image representation and its antecedents
Authors: Verdon James 
Published: May 2016

Abstract
Although there are accepted distinctions between the practices of still and motion photography, a historical investigation into how these art forms pictorially write corroborates shared technologies and techniques, and confirms a common inversion of practices adopted in more traditional forms of text-based writing. The article focuses on nineteenth-century photographic practices as a site within which particular strands of photography and other related image-making exhibit a burgeoning awareness of cinematography, through the use of multiple and sequenced images in single works. These practices reveal certain conditions for writing on the screen and illuminate choices and foci that practitioners held at this time. The use of novel representational technologies is coupled with a fixation on scribing perceptual photorealism during this heady era of invention. This drive creates a sustained emphasis on apprehension and experience at the expense of image materiality, an overlooked indicator of the true nature of reality written on-screen.
Particular aspects of a pancreatic insulinoma case
Authors: Motoc R , Albu C , Munteanu Irina , Dirtu Oana , Motoc Crina , Tilea I 
Published: May 2016

Abstract
With a very low incidence (1-4 cases per 1 million per year), characterized by insulin hypersecretion, independent of the glycemia control system, insulinoma is a rare endocrine tumor, clinical with accentuated neuropsychological symptoms that hampers clinical diagnosis. We present a case of a 33 years old patient with no notable personal history, active lifestyle, non-smoker, a work environment that doesn’t involve professional toxicity; a remarkable family history of a brother with type 1 diabetes mellitus and grandmother with liver adenocarcinoma was noticed; in this particular case Whipple triad was strongly suggestive, gastrointestinal upper-ultrasonography endoscopy with tissue puncture as a tumor diagnostic tool was used and laparotomy was used successfully for removing the tumor, with favorable follow-up.