bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN TINGKAT PENGETAHUAN DENGAN PARTISIPASI PADA PEMERIKSAAN PAP SMEAR PADA WANITA PEKERJA SEKS KOMERSIAL
Authors: Kurniawan Bayu , Asmika Asmika , Sarwono Imam 
Published: January 2017

ABSTRACT Carcinoma cervix is the most frequent malignancy and the highest cancer mortality rate in women worldwideas well as in Indonesian. From 4.290 of cervical carciona in Indonesia , 1.326 cases were found in SurabayaOver 70% patients were in the advanced stadium. Pap Smear as a screening test is a prevention strategy focarcinomaÂ cervix.Â SexÂ workerÂ Â Â hasÂ aÂ highÂ riskÂ forÂ carcinomaÂ cervix.Â ThisÂ researchÂ wasÂ carriedÂ outÂ inÂ GangDollyÂ ProstitutionÂ AreaÂ SurabayaÂ aimedÂ toÂ describeÂ theÂ characteristicsÂ ofÂ sexÂ workerÂ andÂ theÂ correlationbetweenÂ Â Â knowledgeÂ levelÂ andÂ participationÂ inÂ PapÂ SmearÂ examinationÂ .Â AÂ crossÂ sectionalÂ approachÂ wasconducted withÂ 67 respondents. The variables: characteristics, knowledgeÂ level and pap-smearÂ participationwasÂ measuredÂ byÂ openÂ andÂ close-endedÂ questionnaireÂ guidedÂ byÂ theÂ researcher.Â TheÂ dataÂ wereÂ presentedasÂ crossÂ tabulationÂ andÂ furtherÂ testingÂ theÂ correlationÂ basedÂ onÂ Â Â LambdaÂ CorrelationÂ testÂ (Î±Â =Â 0,05).Â TheresultsÂ showedÂ Â Â anÂ equalÂ proportionÂ ofÂ goodÂ andÂ sufficientÂ knowledgeÂ andÂ onlyÂ limitedÂ respondentÂ (2,99%whoÂ haveÂ veryÂ poorÂ knowledge.Â 89,55%Â respondentsÂ haveÂ hadÂ doneÂ theirÂ PapÂ SmearÂ examination,Â fromthoseÂ mostlyÂ wereÂ respondentsÂ withÂ sufficientÂ knowledgeÂ (41,79%).Â Â Â ThereÂ wasÂ aÂ weakÂ andÂ notÂ significancorrelationÂ betweenÂ respondentâ€™sÂ knowledgeÂ levelÂ aboutÂ carcinomaÂ cervixÂ andÂ theirÂ participationÂ inÂ PapSmear examination (Lambda Correlation test, Lb = 0,286, approx. sig. = 0,151). Â Keywords : Knowledge , Carcinoma Cervix, Pap Smear, Participation
TERAPI BIOLOGIK PADA PASIEN PSORIASIS
Authors: Thaha Athuf 
Published: January 2017

ABSTRACT TreatmentÂ limitationsÂ ofÂ currentÂ immunosuppressiveÂ therapies,Â andÂ growingÂ understandingÂ ofÂ psoriasispathogenesis on a molecular level have stimulated much interest in the field of immunomodulatory therapy fomanagement of psoriasis. Genetic engineering has allowed the development of proteins that are targeted tospecific cell surface receptors. A well over 40 targeted biologic agents are in preclinical and clinical testing foT-cellÂ mediatedÂ inflammatoryÂ Â Â diseases,Â includingÂ psoriasis.Â ItÂ isÂ importantÂ that,Â asÂ aÂ doctorÂ becomeÂ weleducated in biologics, since several of these agents are available for the management of psoriasis.Â Â Keywords:Â immunosuppressiveÂ therapy,Â immunomodulatoryÂ therapy,Â geneticÂ engineering,Â surfaceÂ receptors,Â targetedbiologic agents, biologics.
ENCEPHALOPATY AKUT PADA ANAK DENGAN KELAINAN METABOLISME BAWAAN (PENDEKATAN PRAKTIS)
Authors: Puryatni Anik , De Koning Tom J. 
Published: January 2017

ABSTRACT AcuteÂ encephalopathyÂ isÂ aÂ notÂ aÂ common,Â butÂ aÂ potentialÂ emergencyÂ situationÂ inÂ newbornsÂ andÂ youngchildren.Â IfÂ theÂ encephalopathyÂ isÂ notÂ causedÂ byÂ asphyxiaÂ orÂ infectionsÂ ofÂ theÂ brain,Â rareÂ inbornÂ errorsÂ ofmetabolism need to be considered. An acute encephalopathy due to an inborn error can occur in newborns,youngÂ infants,Â orÂ evenÂ inÂ childhoodÂ andÂ isÂ notÂ alwaysÂ easilyÂ recognizedÂ becauseÂ moreÂ subtleÂ presentationscanÂ occur.Â InÂ thisÂ articleÂ weÂ willÂ giveÂ aÂ practicalÂ guidelineÂ toÂ theÂ diagnosticÂ approachÂ ofÂ metabolicÂ diseasespresenting with acute neurological symptoms with an emphasis on treatable disorders and the application indevelopingÂ countriesÂ withÂ limitedÂ diagnosticÂ resources.Â TheÂ firstÂ stepÂ inÂ theÂ evaluationÂ ofÂ patientÂ withÂ apossibleÂ metabolicÂ diseaseÂ isÂ toÂ categoriseÂ theÂ clinicalÂ appearanceÂ ofÂ theÂ patientÂ inÂ oneÂ ofÂ theÂ followingclinical categories: Hypoglycemia phenotype; Intoxication phenotype; Neurotransmitter defect phenotype; andCellular energyÂ metabolism defectÂ phenotype.Â Second, combine this clinical classification with your physicaexaminationÂ andÂ theÂ resultÂ ofÂ routineÂ laboratoryÂ investigationsÂ andÂ thisÂ canÂ leadÂ toÂ suspectedÂ diagnosisÂ ofmetabolicÂ disorders.PromptÂ recognitionÂ andÂ treatmentÂ areÂ important,Â becauseÂ anÂ acuteÂ metabolicencephalopathy can irreversible and interruption of normal neural activity in the developing brain can have along-lastingÂ effectÂ onÂ psychomotorÂ development.Â DelayÂ inÂ diagnosisÂ andÂ treatmentÂ mayÂ thusÂ resultÂ inÂ acutemetabolic decompensation, progressive neurologic injury, or even death. Â Key words: acute encephalopathy, inborn error metabolisme
Perbedaan Pola Peningkatan Suhu Bahan Biologis dan Non-Biologis yang Dipapar Sinar Far-Infrared
Authors: Soleh Miftahu , Sujuti Hidayat , Widjajanto Edi 
Published: January 2017

Low Â power Â of Â Far-Infrared Â Rays Â (FIR) Â emitted Â by Â artificial Â radiators Â have Â been Â used Â for Â many Â diseasesÂ associated with blood vessels disorder. Â FIR also used to Â regulate Â temperature Â in Â incubator Â for Â infant. Â ThisÂ study aims at exploring correlation pattern between FIR and temperature, Â producing a biological simulatorÂ model from Â a Â non-biological Â material for Â further Â research Â can Â be Â initiated. Â Differentiation Â factors Â betweenÂ biological Â and Â non-biological Â material Â that Â exposed Â to Â FIR Â also Â could Â be Â determined. Â A Â radiant Â far-infrared Â typeÂ T -FSR Â was placed 20 cm Â above the Â objects (umbilicus Â and gel). Then both surface Â and inside Â temperature Â ofÂ the Â objects Â measured Â continuously Â using Â Thermistor Â series Â D-S06 Â and Â series Â D-RB2. Â Room Â humidityÂ maintained at constant levels Â (60%). Â This study found Â a significant correlation between FIR and temperatureÂ increasing Â both on the Â umbilicus and on the Â gel. Influence Â of FIR intensity Â on temperature Â can be formulatedÂ into Â the Â formula: Â T_umb_U1 Â = Â 27,6 Â + Â 0,00554 Â FIR Â and Â T_umb_U2 Â = Â 27,8 Â + Â 0,00560 Â FIR, Â while Â on Â the Â gel Â wereÂ T_gel_U1 = 24,9 + 0,00430 FIR and T_gel_U2 = 25,0 + 0,00428 FIR.
Peningkatan Ekspresi Interleukin (IL)-4 Berhubungan dengan Penurunan Bax dan Apoptosis Limfosit pada Bronkiolus dan Paru Mencit Asma
Authors: Yuliarto Saptadi , Kusuma HMS Chandra , Widjajanto Edi 
Published: January 2017

Decrease of lymphocyte Â apoptosis is Â one factor Â that Â leads Â to Â chronic airway inflammation Â in Â allergic asthma.Â Previous Â studies Â revealed Â the Â role Â of Â interleukin Â (IL)-4 Â in Â preventing Â lymphocyte Â apoptosis; Â however Â there Â areÂ few Â studies Â about Â the Â role Â of Â lymphocyte-Bax Â and Â its Â relationship Â with Â IL-4 Â in Â asthma. Â The Â aim Â of Â the Â study Â is Â toÂ demonstrate IL-4 role in preventing lymphocyte apoptosis via lymphocyte-Bax inactivation in bronchioli andÂ lungs Â of Â asthmatic Â mice. Â It Â is Â a Â randomized Â control Â group Â experimental Â study . Â The Â subject Â was Â Balb/c Â mice Â thatÂ categorized Â into Â 2 Â groups: Â asthma Â and Â non-asthma. Â Asthma Â group Â was Â sensitized Â by Â ovalbuminÂ intraperitoneally Â in Â day Â 0 Â and Â 14, Â followed Â by Â inhalation Â every Â 2-3 Â days Â for Â 6 Â weeks. Â In Â week Â 8, Â all Â of Â mice wereÂ terminated. Â The Â IL-4 Â and Â lymphocyte-Bax Â expression Â was Â examined Â through Â immunohistochemistry Â method,Â whereas Â lymphocyte Â apoptosis Â by Â TUNEL Â method. Â Independent Â sample Â t-test, Â Mann Â Whitney Â U Â test,Â regression Â analysis, Â and Â path Â analysis Â was Â used Â in Â statistical Â analysis Â with Â confident Â interval Â 95%. Â TheÂ bronchioli and lungs specimens were obtained from 18 mice (9 in each group). Lymphocyte apoptosis wasÂ similar between 2 groups (p=0.1 16), additionally lymphocyte-Bax Â decreased in Â asthmatic group (p=0.003).Â This Â indicated Â low Â activity Â of Â lymphocyte Â apoptosis Â in Â asthmatic Â group.
Penundaan Makanan Padat Mengurangi Risiko Timbulnya Atopi pada Anak
Authors: Barlianto Wisnu , Kusuma HMS Chandra , HM Ni Luh Putu 
Published: January 2017

Nutritions Â plays Â an Â important Â role Â in Â the Â incidence Â of Â atopic Â both Â in Â children Â and Â adults. Â Several Â recentÂ guidelines Â recommend Â a Â delay Â of Â solid Â foods Â to Â prevent Â atopic Â disease. Â However, Â until Â now, Â there Â is Â still Â muchÂ controversy Â about Â the Â influence Â a Â delay Â of Â solid Â foods Â in Â children Â to Â develop Â atopic Â disease. Â This Â study Â aimedÂ to Â determine Â the Â impact Â of Â the Â start Â time Â of Â solid Â foods Â to Â atopic Â children. Â A Â case-control Â study Â was conductedÂ in Â outpatient Â institutions Â Pediatrics RSSA Â Malang from Â May 2008 Â until Â May 2009. Â Respondents were dividedÂ into two groups: atopic (cases) and non atopic (control) based on history of atopic disease. The age of firstÂ given Â solid Â food Â and Â familial Â atopic Â were retrieved Â based Â on Â history . Â Statistical analysis Â using Â Chi-square testÂ at 95% Â Â level Â of confidence, Â was conducted Â to Â determine the Â impact Â of the Â start Â time Â of solid Â food Â to Â theÂ incidence Â of Â atopic. Â There were 236 Â patients Â divided Â equally Â into Â atopic Â and Â control Â group. Â Giving solid Â foodsÂ at 4-6 months of age will increase Â the Â risk Â of atopic compared Â with age> 6 months (OR Â 2.8 (1.29 Â to Â 6.07), p =Â 0.007). Â The Â results Â of Â this Â study Â support Â the Â recommendations Â given Â by Â WHO, that Â the Â postponement Â of Â solidÂ food Â until Â age Â 6 Â months Â would Â reduce Â the Â incidence Â of Â atopic Â risk Â in Â children.Keywords Â : Â postponement Â , Â solid Â food, Â atopic Â diseases, Â sensitization
Peningkatan Jumlah Apoptosis Airway Smooth MuscleBerhubungan dengan Peningkatan + Jumlah Sel T CD8 pada Model Mencit Asma
Authors: Setiawati Dessy , Kusuma HMS Chandra , Kusworini Kusworini 
Published: January 2017

Airway Â remodeling Â is Â an Â important Â thing Â in Â asthma.The Â increase Â of Â airway Â smooth Â muscle Â mass Â is Â aÂ prominent Â feature Â of Â asthmatic Â airway Â remodeling. Â The importance Â role Â of Â airway Â smooth Â muscle cell Â (ASM)Â +Â apoptosis in airway remodeling is unknown.T cell also had important role in asthma, whereas CD4 T cellÂ +role Â in Â airway Â remodeling Â has Â already Â known, Â but Â how Â CD8 Â T cell Â role Â in Â airway Â remodeling Â is Â still Â unclear. Â AÂ randomized Â control Â group experimental study Â used Balb/c mice, that Â categorized into Â 2 groups: asthma andÂ control. Â Asthma group was sensitized by ovalbumin intraperitoneally Â in Â day 0 and 14, followed Â by inhalationÂ +every Â 2-3 Â days Â for Â 6 Â weeks. Â In Â week Â 8, Â all Â of Â mice Â were Â terminated. Â The Â expression Â of Â CD8 Â T Â cell Â lymphocyteÂ was Â examined Â through Â immunohistochemistry Â method, Â whereas Â ASM Â apoptosis Â by Â TUNEL Â method.Â Independent sample t-test and spearman test was used in statistical analysis with confident interval 95%.Â The Â bronchioli Â and Â lungs Â specimens Â were Â obtained Â from Â 18 Â mice Â (9 Â in Â each Â group). Â Case Â goup Â had Â significantÂ +increase Â in Â the Â amount of ASM apoptosis and expression of CD8 Â T cell lymphocyte Â (p=0.000; Â p=0.001).Â +There was also positif correlation between Â ASM apoptosis and expression of CD8 Â T cell (r=0.37, Â p=0.065).Â +We Â conclude Â that Â increasing Â ASM Â apoptosis Â has Â a Â relationship Â with Â increasing Â CD8 Â T Â cell+Keywords: Â asthma, Â mice, Â ovalbumin, Â ASM Â apoptosis Â and Â CD8 Â T Â cell
Ekspresi dan Aktivasi Reseptor Glukokortikoid serta Ekspresi Heat Shock Protein- 90 pada Sel Limfosit Penderita Sindrom Nefrotik Idiopatik
Authors: Khairiyadi Khairiyadi , Subandiyah Krisni , Fitri Loeki Enggar 
Published: January 2017

Glucocorticoid receptors (GR) have an important role in the resistance of steroid therapy . Previous studiesÂ showed Â significant Â difference Â activation Â and Â expression Â of Â GR Â between Â Steroid Â Resistant Â NephroticÂ Syndrome (SRNS) and Steroid Sensitive Nephrotic Syndrome (SSNS), however the other studies showedÂ contrastive result. Previous studies also revealed Hsp-90 had an important Â role in Â GR activation. The aim ofÂ this study was to determine the differences expression and activation of GR and also Hsp-90 expression inÂ lymphocytes Â cytoplasm Â and Â nucleus Â between Â SRNS Â and Â SSNS Â patients. Â A Â Cross-sectional Â study Â wasÂ conducted Â to Â 40 Â children Â (20 Â SRNS Â and Â 20 Â SSNS Â patients). Â Double Â stainning Â immunocytochemistry Â ofÂ lymphocytes Â was Â performed. Â The Â GR Â expression Â and Â activation Â were Â determined Â by Â counting Â amount Â ofÂ lymphocytes Â that Â express GR and Hsp-90 among 200 under light Â microscope with 1000x magnification. TheÂ differences Â of Â activation Â and Â activation Â of Â GR Â and Â Hsp-90 Â in Â cytoplasm Â and Â nucleus Â were Â analyzed Â withÂ independent t-test and the correlation was analyzed with Pearson correlation.
Pengobatan Suportif Vitamin D Mempercepat Konversi Sputum dan Perbaikan Gambaran Radiologis Penderita T uberkulosis
Authors: Siswanto Siswanto , Sumarno Sumarno , Jane Yani , Widayanti Oeryana Agustin , Muktiati Nunuk Sri 
Published: January 2017

Pulmonary T uberculosis remains Â as a major health problem in Â South East Asia as well as Indonesia. Â TheÂ failure Â of Â tuberculosis Â treatment Â is Â mostly Â due Â to Â drop-out Â and Â multiple Â drugs Â resistant. Â Previous Â study Â showedÂ that Â Vitamin Â D Â increase Â the Â intracellular Â cathelicidin Â which Â has Â potency Â to Â kill Â the Â Mycobacterium tuberculosis.Â This research was aimed to identify the effect of Vitamin D as supportive treatment Â on the improvement ofÂ sputum Â conversion, Â radiographic Â finding Â and Â TNF-Î± Â serum Â concentration. Â A Â Double-blind randomized Â controlÂ trial Â was Â used Â in Â two Â random Â allocated Â patient Â group Â with Â standard Â tuberculosis Â treatment. Â The Â first Â group Â wasÂ treated Â with Vitamin Â D (800 Â iu/day) Â while the Â other was not. Subjects were evaluated using three Â parametersÂ i.e. Â sputum Â conversion, Â radiographic Â finding Â and Â TNF-Î± Â serum Â concentration. Â Compared to Â the Â group Â withoutÂ vitamin Â D Â supplementation, Â group Â with Â vitamin Â D Â has Â higher Â proportion Â of Â sputum Â conversion Â in Â the Â first Â monthÂ (67% Â Â vs. 34%, p=0,04) and second month (95% Â vs. 77%, p=0,18). Â Â Improvement Â in Â radiographic Â findings Â inÂ the Â group with vitamin D is Â also higher in Â the Â first Â month (67% Â vs. 18%, p=0,02) and second month (76% Â Â vs.Â 45%, Â p=0,06). Â Â There is Â a Â significant Â difference Â in Â the Â level Â of Â 25-dihidroxyvitamin Â D between Â two Â groupsÂ (p=0,00). However, Â there Â is Â no significant difference in Â the Â level Â of TNF-Î± between two Â groups (p=0,76) afterÂ two Â months.
Ekspresi dan Aktivasi Sub Unit p65 NF-ÎºB pada Sel Mononuklear Penderita Sindrom Nefrotik Resisten Steroid Anak
Authors: Corebima Brigitta Ida RV , Subandiyah Krisni , Fitri Loeki Enggar 
Published: January 2017

Resitance Â to Â steroid Â therapy Â is Â a Â poor Â prognosis Â sign Â for Â nephrotic Â syndrome, Â but Â this Â mechanism is Â stillÂ unclear. NF-ÎºB has been reported to affect the glucocorticoid at the T cell through the transrepression in Â theÂ glucocorticoid Â receptor . Â Until Â know, Â this Â study Â was Â still Â limited. Â The Â aim Â of Â this Â study Â was Â to Â show Â the Â differenceÂ expression Â and Â activation Â of Â NF-ÎºB Â p65 Â subunit Â between Â childhood Â SRNS Â and Â SSNS Â patient. Â Cross Â sectionalÂ study Â was Â conducted Â during Â January Â 2009 Â to Â December Â 2009 Â in Â the Â Saiful Anwar Â General Â Hospital Â andÂ Biomedic Â Laboratory Â Brawijaya Â University. Â Expression Â and Â activation Â of Â NF-ÎºB Â p65 Â subunit Â were Â determine Â byÂ immunochemistry Â staining Â by Â counting Â the Â amount Â of Â lymphocyte Â that Â express Â and Â activate Â NF-ÎºB Â p65 Â subunitÂ among Â 200 Â lymphocytes Â under Â light Â microscope Â with Â 1000 Â magnification. Â Results Â was Â analyzed Â byÂ independent Â t Â test Â with Â 95% Â CI Â (p<0,05) Â and Â Pearson Â correlation. Â The Â result Â of Â this Â study Â revealed Â noÂ significant Â difference Â of Â expression Â of Â NF-ÎºB p65 Â subunit Â between Â SRNS and Â SSNS Â (p=0,153), Â but Â there Â wasÂ an increase activation of NF-ÎºB p65 subunit in the SRNS patients (p=0,000).
Mastosit Perivaskuler Berperan Sebagai Vasodilator Pembuluh Darah pada Mesenterium Tikus
Authors: Ibrahim Mohamad Nur , Soleh Miftahu , Widjajanto Edi 
Published: January 2017

Mastocyt Â degranulated Â can Â cause Â vasodilatation Â of Â blood Â vessels, Â but Â it Â is Â unclear Â whether Â there Â is Â aÂ relationship Â between the Â number of mastocyt with a diameter of blood vessels. This study aims to Â determineÂ the Â relationship Â between the Â number of mastocyt pherivascular and diameter of blood vessels. Â This researchÂ is Â in Â vivo Â exploratory Â research Â in Â Â Wistar Â rat Â mesentery which was sensitated Â with ovalbumin. Â The Â diameter Â ofÂ blood Â vessels Â at Â mesentery Â preparate Â were Â measured Â microscopically Â using Â a Â micrometer Â scale Â standards. Â AtÂ large Â diameter Â of Â blood Â vessels Â (2.860 Â Â± Â 0.348), Â the Â number Â of Â mastocyt was 12.3 Â Â± Â 2.3. Â At Â medium diameterÂ of blood vessel (1.276 Â± 0.198), the Â number of mastocyt was 4.4 Â± 0.5. Blood vessels with small diameterÂ (0.961 Â± 0.043), the Â number of mastocyt was 3.5 Â± 1.3. Calculations area on the Â microscope visual field Â wasÂ divided into Â four Â areas (counting area), there Â were zone 1, zone 2, zone 3 and zone 4. Statistical analysisÂ showed Â that Â the Â correlation Â between Â the Â number Â of Â mastocyt Â at Â zone Â 1 Â and Â the Â diameter Â of Â blood Â vessels Â wasÂ 0,904 at 1% significance level. Â Similar to Â that Â at zone 2 (r=0,892), Â zone 3 and zone 4 (r=0,940). Â We concludeÂ there Â was Â a Â significant Â relationship Â between Â the Â number Â of Â mastocyt Â and Â the Â diameter Â of Â blood Â vessels.Â Keywords: Â mastocyt Â pherivascular, Â diameter Â of Â blood Â vessels
Laporan Kasus: Tatalaksana Anestesi Penyakit Hirschsprung dengan Sindrom Aspirasi Mekoneum dan Pneumomediastinum pada Neonatus
Authors: Yupono Karmini , Hartono Ruddi 
Published: January 2017

We report Â one female Â newborn baby suffered from Â moderate asphyxia, meconium aspiration syndrome, andÂ Hirschsprung Â disease. Â The Â patient Â admitted Â in Â Neonatal Â Intensive Â Care Â Unit Â (NICU) Â and Â ventilated Â withÂ Pressure Controlled Mandatory Ventilation (PCMV) Â mode ventilator. Â Patient suffered from Â pneumodiastinumÂ and therefore Â mediastinotomy was performed. Sepsis and Necrotizing Enterocolitis (NEC) Â made the Â caseÂ more Â complicated. Â On Â further Â examination, Â abdominal Â was Â distended Â and Â perforated Â and Â therefore Â weÂ decided Â to Â perform Â exploration Â laparatomy Â and Â sigmoidoctomy . Â Anaesthesia Â management Â with Â generalÂ anaesthesia Â had Â been Â performed. Â Premedication Â was Â not Â given. Â We Â used Â oxygen Â and Â Sevofluran Â forÂ induction; Â Oxygen, Sevofluran, Atracurium, Fentanyl, Â and Â Morphin for Â maintenance; and Â Morphin for Â postÂ operative analgesic. On follow up examination, we found wound disruption and therefore relaparotomy wasÂ performed. Â T ypes Â and Â doses Â of Â anesthesia Â drugs Â were Â chosen Â according Â to Â newborn Â immature Â organ Â noticely .Â Providing adequate oxygenation, preventing hypotermi, and balancing electrolytes and acid base states stillÂ be the Â most considerations in Â management of this Â patient. Â Anesthetic management and intensive Â care of thisÂ patient Â gained Â a Â satisfying Â outcome. Â The Â prognosis Â was Â good.Â Keywords: Â Hirschsprung Â disease, Â meconium Â aspiration Â syndrome, Â pneumomediastinum, Â sepsis, Â NEC.
Korelasi Antara Transforming Growth Factor -Î’1 Monosit dengan Kebocoran Vaskuler pada Demam Berdarah Dengue
Authors: Supriatna Mohamad , Tondy Haryson , Ermin Tatty , Istanti Yusrina , RMD Kisdjamiatun 
Published: January 2017

ABSTRAKSel monosit merupakan target utama infeksi virus Demam Berdarah Dengue (DBD) yang dapat memproduksi faktorÂ vasoaktif yang mempengaruhi fungsi sel endotel dan berperan dalam kebocoran vaskuler. Transforming growth factorÂ beta 1 (TGF-1) merupakan salah satu sitokin yang mempunyai banyak peran dalam patogenesis DBD. Penelitian iniÂ dilakukan untuk mengidentifikasi hubungan antara TGF-1 terhadap indeks efusi pleura (IEP), total protein, albumin danÂ hematokrit sebagai indikator kebocoran vaskular. Studi dilakukan dengan desain cross sectional pada pasien DBD usia 13-14 tahun di RS dr. Kariadi selama Juli 2005 hingga Juli 2006. Sampel pemeriksaan adalah kultur whole blood supernatantÂ culture yang diinduksi LPS pada subyek penelitian. Kadar monosit TGF-1, PEI, total protein, albumin dan hematokrit diukurÂ pada hari 0 dan 2. Data di analisis dengan uji Wilcoxon dan korelasi Spearman. Pada hari 0 dan 2 dianalisis korelasi antaraÂ kadar monosit TGF-1, PEI juga protein total, albumin dan hematokrit. Rerata kadar TGF-1 monosit pada hari ke 2Â (43.29Â±28.012 pg/ml) lebih tinggi dari hari 0 (35.27 Â± 34.642 pg/ml, p=0.09, Wilcoxon test). Pada hari 0 terdapat korelasiÂ signifikan level TGF-1 monosit dengan PEI (r=-0.31, p=0.04), tetapi tidak dengan total protein (r=0.19, p=0.2), albuminÂ (r=0.11, p=0.5 ; r=--.08, p=0.6). Pada hari kedua tidak ada korelasi signifikan antara level TGF-1 monosit level dan PEI (r=-0.2,p=0.3), total protein (r=0.2, p=0.2), albumin (r-0.2, p=0.2) dan hematokrit (r=-0.04, p=0.8). Dapat di simpulkan bahwaÂ TGF-1 mungkin berperan dalam proses inflamasi DBD melalui PEI sebagai salah satu indikator kebocoran plasma.Kata Kunci : Albumin, DBD, hematokrit, IEP, TGF-1, protein totalÎ²
Ekstrak Jinten Hitam Memperbaiki Penyempitan Jalan Nafas pada Model Mencit Asthma
Authors: Sriwahyuni Endang , Risza Faradina , Yuni Anita 
Published: January 2017

ABSTRAKRemodeling jalan nafas pada asma merupakan perubahan yang bersifat ireversibel dan di tunjukkan dengan penebalanÂ epitel. Asma merupakan kondisi hipersensitif jalan nafas yang disebabkan inflamasi dan ditunjukkan dengan penyempitanÂ bronkus. Jinten hitam sudah digunakan untuk pengobatan asma sejak lama. Studi dilakukan untuk menguji efek jintenÂ hitam dalam mencegah penebalan bronkus dan membuktikan efek bronkodilator dengan peningkatan lingkar lumenÂ bronkus pada model mencit asma betina dengan eksperimental in vivo. Mencit model asma dikembangkan denganÂ memberikan sensitisasi allergen ovalbumin yang diberikan intraperitoneal dua kali dalam 3 minggu (haro 0 dan 14)Â dilakukan per inhalasi tiga kali seminggu selama 6 minggu. Ekstrak jinten hitam diberikan dalam 3 dosis (1,2g; 2,4 g and 4,8Â g/kgBB/hari) selama 9 minggu. Hasil penelitian menunjukkan bahwa pemberian jintan hitam dapat mencegah penebalanÂ epitel bronkus dengan dosisi efektif 2,4 g/Kg BB/hari dan meningkatkan lingkar lumen bronchial dengan dosis efektif 4,8Â g/KgBB/hari. Dapat disimpulkan pemberian ekstrak jintan mencegah penebalan epital bronkus dan meningkatkan lingkarÂ lumen bronchial pada mencit model asma.Kata Kunci : Asma, inflamasi, jinten hitam, lingkar lumen bronkus, penebalan epitel bronkus