bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mahalanobis-Taguchi system: state of the art
Authors: Mota-Gutiérrez Cecilia Guadalupe , Reséndiz-Flores Edgar Omar , Reyes-Carlos Yadira Iracema 
Published: January 2018

Purpose
The purpose of this paper is to show a bibliographical review of the applications of the MTS throughout the time and the different fields.

Design/methodology/approach
The Mahalanobis-Taguchi system (MTS) is an analytical method used for the diagnosis and/or pattern recognition of multivariate data for quantitative decision making.

Findings
Its scope is very broad, ranging from engineering, medicine, education, and manufacturing, among others. This work presents a classification of the literature in the following areas of the MTS: introduction of the method, cases of study/application, comparison with other methods, integration and development of the MTS with other methods, construction of Mahalanobis space, dimensional reduction and threshold establishment. It realized a wide search of the publications in magazines and congresses.

Originality/value
This paper is a summary of the main applications, contributions and changes to MTS.
Digital preservation at Big Data scales: proposing a step-change in preservation system architectures
Authors: Gerrard David Maynard , Mooney James Edward , Thompson Dave 
Published: January 2018

Purpose
The purpose of this paper is to consider how digital preservation system architectures will support business analysis of large-scale collections of preserved resources, and the use of Big Data analyses by future researchers.

Design/methodology/approach
This paper reviews the architecture of existing systems, then discusses experimental surveys of large digital collections using existing digital preservation tools at Big Data scales. Finally, it introduces the design of a proposed new architecture to work with Big Data volumes of preserved digital resources – also based upon experience of managing a collection of 30 million digital images.

Findings
Modern visualisation tools enable business analyses based on file-related metadata, but most currently available systems need more of this functionality “out-of-the-box”. Scalability of preservation architecture to Big Data volumes depends upon the ability to run preservation processes in parallel, so indexes that enable effective sub-division of collections are vital. Not all processes scale easily: those that do not require complex management.

Practical implications
The complexities caused by scaling up to Big Data volumes can be seen as being at odds with preservation, where simplicity matters. However, the sustainability of preservation systems relates directly to their usefulness, and maintaining usefulness will increasingly depend upon being able to process digital resources at Big Data volumes. An effective balance between these conflicting situations must be struck.

Originality/value
Preservation systems are at a step-change as they move to Big Data scale architectures and respond to more technical research processes. This paper is a timely illustration of the state of play at this pivotal moment.
Effect of combined epidural anaesthesia on tumor‐infiltrating lymphocytes in lung adenocarcinoma: a prospective exploratory sub‐analysis
Authors: Li M.‐H. , Xu Z.‐Z. , Huang S.‐M. , Li T. , Li X.‐Y. , Wang D.‐X. 
Published: January 2018

BackgroundRegional anaesthesia may have advantages in preserving immune function. Tumor‐infiltrating lymphocytes (TILs) are considered indicators of immune response in the tumor microenvironment and used as a prognostic marker in patients after cancer surgery. This study investigated the effects of combined epidural anaesthesia on the number of TILs in patients undergoing surgery for lung adenocarcinoma.MethodsPatients undergoing radical resection for primary lung cancer were randomized to receive either combined epidural‐general anaesthesia (Epi‐GA) or general anaesthesia (GA) in an ongoing randomized controlled trial (ChiCTR‐TRC‐14004136). Excised adenocarcinoma specimens from patients enrolled between 1 June 2015 and 30 November 2015 were selected for immunohistochemical staining of CD8 and FOXP3 molecules. The numbers of positive lymphocytes were counted and expressed as the number of cells per mm2 tumor area.ResultsOne hundred and twenty‐eight patients were recruited and randomized; 64 patients were included in immunohistochemistry analysis (37 received Epi‐GA vs. 27 received GA). The number of CD8+ T cells was higher in the Epi‐GA group than in the GA group (median [interquartile range]: 292.8 [198.0–418.3] vs. 204.7 [131.1–305.8], P = 0.036); whereas the number of FOXP3+ T cells was less in the Epi‐GA group than in the GA group (37.6 [14.7–92.3] vs. 99.8 [68.9–168.3], P < 0.001).ConclusionsFor patients undergoing surgery for lung adenocarcinoma under general anesthesia, use of epidural anaesthesia increased CD8+ T cells infiltration but decreased FOXP3+ T cells accumulation in tumor tissues. Epidural anaesthesia may affect TILs in a manner that preserves immune function.
Leader Influence and Reputation Formation in World Politics
Authors: Renshon Jonathan , Dafoe Allan , Huth Paul 
Published: January 2018

AbstractThe study of reputation is one of the foundational topics of modern international relations. However, fundamental questions remain, including the question of to whom reputations adhere: states, leaders, or both? We offer a theory ofinfluence‐specificreputations (ISR) that unifies competing accounts of reputation formation. We theorize that reputations will adhere more to actors who are more influential in the relevant decision‐making process. We employ two survey experiments, one abstract and one richly detailed involving a U.S.‐Iran conflict, to evaluate ISR. We find evidence of large country‐specific reputations and moderately sized leader‐specific reputations. Consistent with the theory of influence‐specific reputations, leader‐specific reputations are more important when leaders are more influential.
The Public Cost of Unilateral Action
Authors: Reeves Andrew , Rogowski Jon C. 
Published: January 2018

AbstractScholarship on democratic responsiveness focuses on whether political outcomes reflect public opinion but overlooks attitudes toward how power is used to achieve those policies. We argue that public attitudes toward unilateral action lead to negative evaluations of presidents who exercise unilateral powers and policies achieved through their use. Evidence from two studies supports our argument. In three nationally representative survey experiments conducted across a range of policy domains, we find that the public reacts negatively when policies are achieved through unilateral powers instead of through legislation passed by Congress. We further show these costs are greatest among respondents who support the president's policy goals. In an observational study, we show that attitudes toward unilateral action in the abstract affect how respondents evaluate policies achieved through unilateral action by presidents from Lincoln to Obama. Our results suggest that public opinion may constrain presidents' use of unilateral powers.
The Financialisation of Rental Housing 2.0: Releasing Housing into the Privatised Mainstream of Capital Accumulation
Authors: Wijburg Gertjan , Aalbers Manuel B. , Heeg Susanne 
Published: January 2018

AbstractThis article presents two cases of listed real estate companies that operate in the Ruhr metropolitan region of Germany. The first is Immeo Wohnen, a subsidiary of the French real estate investment trust (REIT) Foncière des Régions that was previously owned by a US hedge fund. The second is Vonovia, Germany's largest real estate company, originally a subsidiary of a British private equity firm. Both examples embody what we call the shift from financialisation 1.0 to financialisation 2.0, i.e. the transition from pure speculation to long‐term investment. We show that long‐term investment strategies are used by REITs and listed funds in order to release housing into the privatised mainstream of capital accumulation. With the advent of the financialisation of rental housing 2.0, the long‐term investment focus of these funds paradoxically enables a short‐term investment focus by buying and selling shares in these funds on the stock exchange.
Use of social media is associated with short sleep duration in a dose–response manner in students aged 11 to 20 years
Authors: Sampasa‐Kanyinga Hugues , Hamilton Hayley A , Chaput Jean‐Philippe 
Published: January 2018

AbstractAimThis study examined the association between social media and sleep duration among Canadian students aged 11–20.MethodsData from 5242 students were obtained from the 2015 Ontario Student Drug Use and Health Survey, a province‐wide, school‐based survey that has been conducted every two years since 1977. We measured the respondents’ sleep duration against the recommended ranges of 9–11 h per night at 11–13 years of age, 8–10 h at 14–17 and 7–9 h per night for those aged 18 years or more.ResultsOverall, 36.4% of students met or exceeded the recommended sleep duration and 63.6% slept less than recommended, with 73.4% of students reporting that they used social media for at least one hour per day. After adjusting for various covariates, the use of social media was associated with greater odds of short sleep duration in a dose–response manner (p for linear trend <0.001). Odds ratios ranged from 1.82 for social media use of at least one hour per day to 2.98 for at least five hours per day.ConclusionGreater use of social media was associated with shorter sleep duration in a dose–response fashion among Canadian students aged 11–20.
Expression of activating natural killer‐cell receptors is a hallmark of the innate‐like T‐cell neoplasm in peripheral T‐cell lymphomas
Authors: Uemura Yu , Isobe Yasushi , Uchida Akiko , Asano Junko , Nishio Yuji , Sakai Hirotaka , Hoshikawa Masahiro , Takagi Masayuki , Nakamura Naoya , Miura Ikuo 
Published: January 2018

Peripheral T‐ or natural killer (NK)‐cell lymphomas are rare and difficult‐to‐recognize diseases. It remains arduous to distinguish between NK cell‐ and cytotoxic T‐lymphocyte‐derived lymphomas through routine histological evaluation. To clarify the cells of origin, we focused on NK‐cell receptors and examined the expression using immunohistochemistry in 22 cases with T‐ and NK‐cell neoplasms comprising angioimmunoblastic T‐cell lymphoma, anaplastic lymphoma kinase (ALK)‐positive and ‐negative anaplastic large‐cell lymphomas, extranodal NK/T‐cell lymphoma, nasal type, monomorphic epitheliotropic intestinal T‐cell lymphoma, aggressive NK‐cell leukemia, and other peripheral T‐cell lymphomas. Inhibitory receptor leukocyte immunoglobulin‐like receptor subfamily B member 1 (LILRB1) was detected in 14 (64%) cases, whereas activating receptors DNAM1, NKp46, and NKG2D were expressed in 7 (32%), 9 (41%), and 5 (23%) cases, respectively. Although LILRB1 was detected regardless of the disease entity, the activating NK‐cell receptors were expressed predominantly in TIA‐1‐positive neoplasms (DNAM1, 49%; NKp46, 69%; and NKG2D, 38%). In addition, NKp46 and NKG2D were detected only in NK‐cell neoplasms and cytotoxic T‐lymphocyte‐derived lymphomas including monomorphic epitheliotropic intestinal T‐cell lymphoma. One Epstein‐Barr virus‐harboring cytotoxic T‐lymphocyte‐derived lymphoma mimicking extranodal NK/T‐cell lymphoma, nasal type lacked these NK‐cell receptors, indicating different cell origin from NK and innate‐like T cells. Furthermore, NKG2D expression showed a negative impact on survival among the 22 examined cases, which mainly received the standard chemotherapy regimen (log‐rank test, P = .024). We propose that the presence of activating NK‐cell receptors may provide new insights into understanding peripheral T‐cell lymphomas and characterizing them as innate‐like T‐cell neoplasm.
E7777 in Japanese patients with relapsed/refractory peripheral and cutaneous T‐cell lymphoma: A phase I study
Authors: Ohmachi Ken , Ando Kiyoshi , Ogura Michinori , Uchida Toshiki , Tobinai Kensei , Maruyama Dai , Namiki Masayuki , Nakanishi Tadashi 
Published: January 2018

E7777, a recombinant cytotoxic fusion protein comprising diphtheria toxin fragments A and B and human interleukin‐2, shares an amino acid sequence with denileukin diftitox but has improved purity and an increased percentage of active protein monomer species. A phase I study was carried out to evaluate the tolerability, safety, pharmacokinetics, and antitumor activity of E7777 in Japanese patients with relapsed/refractory peripheral and cutaneous T‐cell lymphoma. E7777 (6, 12, and expanded 9 μg/kg/day) was given to 13 patients by i.v. infusion on five consecutive days per 21‐day cycle. Dose‐limiting toxicities, including increased alanine aminotransferase, hyponatremia (n = 2), hypokalemia, lymphopenia, fatigue, hypoalbuminemia, rash, and increased lipase (n = 1), were observed in all three patients in the 12 μg/kg/day cohort, whereas two of six patients in the 9 μg/kg/day cohort showed decreased appetite or fatigue. The maximum tolerated and recommended dose of E7777 was 9 μg/kg/day for five consecutive days per 21‐day cycle. The objective response rate was 38% (5/13) and did not appear to depend on tumor expression of CD25. E7777 was well tolerated, assuming careful management of adverse events during treatment, and preliminary but clinically meaningful antitumor activity was observed. Subsequent studies of E7777 for T‐cell lymphomas are warranted. This study was registered with www.ClinicalTrials.gov (NCT1401530).
In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB
Authors: Hrast Martina , Jukič Marko , Patin Delphine , Tod Julie , Dowson Christopher G. , Roper David I. , Barreteau Hélène , Gobec Stanislav 
Published: January 2018

In the context of antibacterial drug discovery resurgence, novel therapeutic targets and new compounds with alternative mechanisms of action are of paramount importance. We focused on UDP‐N‐acetylenolpyruvylglucosamine reductase (i.e. MurB), an underexploited target enzyme that is involved in early steps of bacterial peptidoglycan biosynthesis. On the basis of the recently reported crystal structure of MurB in complex with NADP+, a pharmacophore model was generated and used in a virtual screening campaign with combined structure‐based and ligand‐based approaches. To explore chemical space around hit compounds, further similarity search and organic synthesis were employed to obtain several compounds with micromolar IC50 values on MurB. The best inhibitors in the reported series of 5‐substituted tetrazol‐2‐yl acetamides were compounds 13, 26 and 30 with IC50 values of 34, 28 and 25 μm, respectively. None of the reported compounds possessed in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli.
Effects of a physical activity programme in the school setting on physical fitness in preschool children
Authors: Latorre‐Román P. A. , Mora‐López D. , García‐Pinillos F. 
Published: January 2018

AbstractAimThe purpose of this study was to examine the effects of a 10‐week aerobic games programme on physical fitness.MethodsOne hundred eleven children, aged 3 to 6 years, participated in this study; 60 children were male (age: 4.28 ± 0.61 years old), and 51 were female (age 4.59 ± 0.49 years old). Participants were randomly assigned to an experimental group (EG; n = 56) and a control group (CG; n = 55). A fitness test battery previously validated for preschoolers was used. The children in the EG performed 3 weekly training sessions of physical activity in a classroom during a 10‐week period. Every EG session lasted about 30 min.ResultsThere were no significant differences in any variable in the pretest between groups. In the posttest, the EG achieved better results in horizontal jump and sprint. In relation to posttest–pretest differences, the EG showed a greater increase in horizontal jump, sprint, and endurance.ConclusionAn aerobic games programme in the school setting improved physical fitness in preschool children.
Assessing relative cost of complications following orthotopic liver transplant
Authors: Bhutiani Neal , Jones Christopher M. , Cannon Robert M. , Wei David , Goldstein Laura , Roy Sanjoy , Philips Prejesh , Scoggins Charles R. , McMasters Kelly M. , Martin Robert C. G. 
Published: January 2018

AbstractIntroductionPerioperative complications impose both a clinical and financial burden on patients and the healthcare system. This study sought to identify the frequency and economic impact of complications following orthotopic liver transplantation (OLT).MethodsThe Premier Perspective® Hospital Database was queried for patients undergoing OLT between 2008 and 2015. Complications were identified by ICD‐9 code and grouped by complication type. Complication frequency as well as impact on clinical and economic outcomes was calculated. Complication frequency and effect on cost were combined to determine the annual impact of each complication type on perioperative OLT cost.ResultsAmong 2747 OLT patients, the most common groups of complications following OLT were pulmonary, bleeding, and infectious. The complications with the greatest average effect on treatment‐related costs were infectious, neurologic, deep vein thrombosis/pulmonary embolus, and hepatic arterial thrombosis. Infectious, pulmonary, and bleeding complications had the greatest annual effect on perioperative OLT cost.ConclusionsEfforts focused on preventing coagulopathic bleeding, improving post‐operative pulmonary toilet, and minimizing sources of infection can help improve the cost‐effectiveness of OLT. Additionally, the combination of these cost data and systematized protocols can help insurers construct bundled payments for OLT that more accurately reflect the cost of perioperative transplant care.
Financialization and Economic Development: A Debate on the Social Efficiency of Modern Finance
Authors: Storm Servaas 
Published: January 2018

ABSTRACTThe shift in financial intermediation from banks to financial markets, and the introduction of financial market logic into areas and domains where it was previously absent, have not just led to negative developmental impacts, but also changed the ‘rules of the game’ and facilitated rent‐seeking practices of a self‐serving global elite. Establishment (financial) economics has helped to depoliticize and legitimize this financialized mode of social regulation by invoking Hayek's epistemological claim that (financial) markets are the only legitimate, reliably welfare‐enhancing foundation for a stable social order and economic progress. This article forms the Introduction to a set of 10 articles which assess the logic and consequences of ‘financialization’ across a range of geographic, economic and social scales, and confront Hayek's grotesque claim — deep down, at the level of ‘ideas’, but also by providing ‘knock‐out evidence’ on the social inefficiency of a capitalism ‘without compulsions’ for finance. The authors in the Debate challenge the ‘ruling ideas’ and expose how establishment economics has been hiding its reactionary political agenda behind the pretence of scientific neutrality. The financial emperor wears no clothes.
Numerical Modeling of Methane Leakage from a Faulty Natural Gas Well into Fractured Tight Formations
Authors: Moortgat Joachim , Schwartz Franklin W. , Darrah Thomas H. 
Published: January 2018

AbstractHorizontal drilling and hydraulic fracturing have enabled hydrocarbon recovery from unconventional reservoirs, but led to natural gas contamination of shallow groundwaters. We describe and apply numerical models of gas‐phase migration associated with leaking natural gas wells. Three leakage scenarios are simulated: (1) high‐pressure natural gas pulse released into a fractured aquifer; (2) continuous slow leakage into a tilted fractured formation; and (3) continuous slow leakage into an unfractured aquifer with fluvial channels, to facilitate a generalized evaluation of natural gas transport from faulty natural gas wells. High‐pressure pulses of gas leakage into sparsely fractured media are needed to produce the extensive and rapid lateral spreading of free gas previously observed in field studies. Transport in fractures explains how methane can travel vastly different distances and directions laterally away from a leaking well, which leads to variable levels of methane contamination in nearby groundwater wells. Lower rates of methane leakage (≤1 Mcf/day) produce shorter length scales of gas transport than determined by the high‐pressure scenario or field studies, unless aquifers have low vertical permeabilities (≤1 millidarcy) and fractures and bedding planes have sufficient tilt (∼10°) to allow a lateral buoyancy component. Similarly, in fractured rock aquifers or where permeability is controlled by channelized fluvial deposits, lateral flow is not sufficiently developed to explain fast‐developing gas contamination (0‐3 months) or large length scales (∼1 km) documented in field studies. Thus, current efforts to evaluate the frequency, mechanism, and impacts of natural gas leakage from faulty natural gas wells likely underestimate contributions from small‐volume, low‐pressure leakage events.
Modulation of electrostriction and strain response in bismuth sodium titanate‐based ceramics
Authors: Zhang Yuxing , Yin Jie , Zhao Chunlin , Wu Bo , Wu Jiagang 
Published: January 2018

AbstractThe electrostriction and strain response of lead‐free Bi0.5Na0.5TiO3–BaTiO3 piezoceramics with La and Nb [(Bi0.47Na0.47Ba0.06)1−xLaxTi1−yNbyO3] were modified by optimizing the depolarization temperature. The influences of La and Nb on their phase structure and electrical properties were systematically investigated. All the ceramics exhibited a pseudocubic phase, which is independent of the addition of La and Nb. The strain values increased gradually with the addition of La, and a high strain of ~0.5% (80 kV/cm) was attained without any remnant strain when the compositions had a value of x = 0.015. Instead, the piezoelectric constant d33 dropped down ~20 pC/N due to the shift of the Td (or Tf−r) to room temperature. Interestingly, by establishing the relationship between Td and strain values, it should be feasible to optimize the strain property of Bi0.5Na0.5TiO3 (BNT)‐based ceramics by regulating Td to ambient temperature. In addition, a very high electrostriction coefficient Q33 of ~0.0758 m4 C−2 can be found under high temperatures of 125 and 150°C. We believe that the strain and electrostriction behavior of BNT‐based ceramics can be well modified by the modulation of depolarization temperature.
Use of antibiotic envelopes to prevent cardiac implantable electronic device infections: A meta‐analysis
Authors: Koerber Scott M. , Turagam Mohit K. , Winterfield Jeffery , Gautam Sandeep , Gold Michael R. 
Published: January 2018

AbstractIntroductionThe rates of cardiac implantable electronic device (CIED) infections have risen over the past decade and are associated with increased hospitalizations and mortality. A number of preventative strategies have been developed including an antibiotic coated envelope, but it has yet to gain widespread use.MethodsA meta‐analysis was performed on controlled studies of the antibiotic envelope. PubMed and Google Scholar were searched for studies comparing infection rates with and without the use of an antibiotic envelope. Studies including both new implants and pulse generator replacements were included in the analysis.ResultsFive studies were included in the meta‐analysis. A total of 4,490 patients underwent CIED implantation, 1,798 with an antibiotic envelope and 2,692 without an envelope. In the pooled cohort, the envelope was associated with a 69% relative risk reduction in CIED infection (0.31 [0.17, 0.58] 95% CI, P = 0.0002). Propensity matched data from three studies were analyzed to ensure accurate comparison. In the risk‐matched cohort, infections were significantly lower in the envelope group (3 vs. 26, P < 0.0003).ConclusionThe use of antibiotic envelopes in CIED implant is associated with a significantly lower rate of infection.