bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triple-Moment Modal Parameterization for the Adaptive Growth Habit of Pristine Ice Crystals
Authors: Chen Jen-Ping , Tsai Tzu-Chin 
Published: November 2015

Abstract
A three-moment modal parameterization scheme was developed for describing variations in the shape of cloud ice crystals during growth by vapor deposition. The shape of ice crystals is represented using the volume-weighted aspect ratio, while the size spectrum of the crystal population is described using a three-parameter gamma function. Verified with binned spectral calculations, the proposed modal scheme performed quite accurately in the evolution of the mass and shape of cloud ice crystals growing under idealized conditions. The associated error is within 1% in mass after 1000 s of growth under water saturation. When the ventilation effect is taken into account, the error remains within 5%. Error with regard to the bulk aspect ratio is generally about 3%. A failure to take into account the ice crystal shape led to a 45% underestimation in mass growth. Using only two moments to describe the gamma distribution led to a 37% underestimation in mass and 28% underestimation in the bulk aspect ratio of the ice crystals. The proposed scheme is able to capture the shape memory effect and the gradual adaptation of ice crystal aspect ratios to a new growth habit regime.
Winter Atmospheric Buoyancy Forcing and Oceanic Response during Strong Wind Events around Southeastern Greenland in the Regional Arctic System Model (RASM) for 1990–2010*
Authors: DuVivier Alice K. , Cassano John J. , Craig Anthony , Hamman Joseph , Maslowski Wieslaw , Nijssen Bart , Osinski Robert , Roberts Andrew 
Published: November 2015

Abstract
Strong, mesoscale tip jets and barrier winds that occur along the southeastern Greenland coast have the potential to impact deep convection in the Irminger Sea. The self-organizing map (SOM) training algorithm was used to identify 12 wind patterns that represent the range of winter [November–March (NDJFM)] wind regimes identified in the fully coupled Regional Arctic System Model (RASM) during 1990–2010. For all wind patterns, the ocean loses buoyancy, primarily through the turbulent sensible and latent heat fluxes; haline contributions to buoyancy change were found to be insignificant compared to the thermal contributions. Patterns with westerly winds at the Cape Farewell area had the largest buoyancy loss over the Irminger and Labrador Seas due to large turbulent fluxes from strong winds and the advection of anomalously cold, dry air over the warmer ocean. Similar to observations, RASM simulated typical ocean mixed layer depths (MLD) of approximately 400 m throughout the Irminger basin, with individual years experiencing MLDs of 800 m or greater. The ocean mixed layer deepens over most of the Irminger Sea following wind events with northerly flow, and the deepening is greater for patterns of longer duration. Seasonal deepest MLD is strongly and positively correlated to the frequency of westerly tip jets with northerly flow.
Submesoscale Dynamics of a Gulf Stream Frontal Eddy in the South Atlantic Bight
Authors: Gula Jonathan , Molemaker M. Jeroen , McWilliams James C. 
Published: November 2015

AbstractFrontal eddies are commonly observed and understood as the product of an instability of the Gulf Stream along the southeastern U.S. seaboard. Here, the authors study the dynamics of a simulated Gulf Stream frontal eddy in the South Atlantic Bight, including its structure, propagation, and emergent submesoscale interior and neighboring substructure, at very high resolution (dx = 150 m). A rich submesoscale structure is revealed inside the frontal eddy. Meander-induced frontogenesis sharpens the gradients and forms very sharp fronts between the eddy and the adjacent Gulf Stream. The strong straining increases the velocity shear and suppresses the development of barotropic instability on the upstream face of the meander trough. Barotropic instability of the sheared flow develops from small-amplitude perturbations when the straining weakens at the trough. Small-scale meandering perturbations evolve into rolled-up submesoscale vortices that are advected back into the interior of the frontal eddy. The deep fronts mix the tracer properties and enhance vertical exchanges of tracers between the mixed layer and the interior, as diagnosed by virtual Lagrangian particles. The frontal eddy also locally creates a strong southward flow against the shelf leading to topographic generation of submesoscale centrifugal instability and mixing. In eddy-resolving models that do not resolve these submesoscale processes, there is a significant weakening of the intensity of the upwelling in the core of the frontal eddies, and their decay is generally too fast.
Estimation of Volcanic Ash Emissions Using Trajectory-Based 4D-Var Data Assimilation
Authors: Lu S. , Lin H. X. , Heemink A. W. , Fu G. , Segers A. J. 
Published: November 2015

Abstract
Volcanic ash forecasting is a crucial tool in hazard assessment and operational volcano monitoring. Emission parameters such as plume height, total emission mass, and vertical distribution of the emission plume rate are essential and important in the implementation of volcanic ash models. Therefore, estimation of emission parameters using available observations through data assimilation could help to increase the accuracy of forecasts and provide reliable advisory information. This paper focuses on the use of satellite total-ash-column data in 4D-Var based assimilations. Experiments show that it is very difficult to estimate the vertical distribution of effective volcanic ash injection rates from satellite-observed ash columns using a standard 4D-Var assimilation approach. This paper addresses the ill-posed nature of the assimilation problem from the perspective of a spurious relationship. To reduce the influence of a spurious relationship created by a radiate observation operator, an adjoint-free trajectory-based 4D-Var assimilation method is proposed, which is more accurate to estimate the vertical profile of volcanic ash from volcanic eruptions. The method seeks the optimal vertical distribution of emission rates of a reformulated cost function that computes the total difference between simulated and observed ash columns. A 3D simplified aerosol transport model and synthetic satellite observations are used to compare the results of both the standard method and the new method.
Causes for 30‐Day Readmission following Transsphenoidal Surgery
Authors: Hendricks Brian L. , Shikary Tasneem A. , Zimmer Lee A. 
Published: November 2015

ObjectiveThe Affordable Care Act Readmissions Reduction Program introduced reimbursement policy changes resulting in penalties for hospitals with higher‐than‐average readmission rates among several categories, including elective surgical cases. We examined the rate of complications resulting in 30‐day readmission following endoscopic transsphenoidal surgery.Study DesignCase series with chart review.SettingAcademic tertiary care center.MethodsA database of 466 consecutive patients who underwent endoscopic transsphenoidal surgery at a tertiary care center between April 2006 and July 2014 was reviewed for 30‐day causes for readmission, length of stay, level of care required, and average cost.ResultsTwenty‐nine readmissions were identified within our study period, indicating a 30‐day readmission rate of 6.2%. Among all patients, rates of 30‐day readmission were 2.1% for epistaxis, 1.5% for hyponatremia, 0.9% for cerebrospinal fluid leak, and 1.7% for other medical conditions. Average cost per readmission ranged from $6011 for hyponatremia to $24,613 for cerebrospinal fluid leak.ConclusionOverall, the rate of 30‐day readmission following endoscopic pituitary surgery is low. However, common causes of readmission do add significant cost to the overall care of this patient population. Special attention to surgical technique to prevent epistaxis and cerebrospinal fluid rhinorrhea, as well as multidisciplinary team management to avoid postoperative endocrine dysfunction, is critical to minimize these complications.
The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial
Authors: Englund Amir , Atakan Zerrin , Kralj Aleksandra , Tunstall Nigel , Murray Robin , Morrison Paul 
Published: November 2015

Rationale: Cannabis is mostly grown under illegal and unregulated circumstances, which seems to favour a product increasingly high in its main cannabinoid ∆-9-tetrahydrocannabinol (THC). ∆-9-tetrahydrocannabivarin (THCV) is a relatively untested cannabinoid which is said to be a cannabinoid receptor neutral antagonist, and may inhibit the effects of THC. Objectives: To explore the safety and tolerability of repeated THCV administration and its effects on symptoms normally induced by THC in a sample of healthy volunteers. Methods: Ten male cannabis users (<25 use occasions) were recruited for this within-subjects, placebo-controlled, double-blind, cross-over pilot study. 10mg oral pure THCV or placebo were administered daily for five days, followed by 1mg intravenous THC on the fifth day. Results: THCV was well tolerated and subjectively indistinguishable from placebo. THC did not significantly increase psychotic symptoms, paranoia or impair short-term memory, while still producing significant intoxicating effects. Delayed verbal recall was impaired by THC and only occurred under placebo condition ( Z=-2.201, p=0.028), suggesting a protective effect of THCV. THCV also inhibited THC-induced increased heart rate ( Z=-2.193, p=0.028). Nine out of ten participants reported THC under THCV condition (compared to placebo) to be subjectively weaker or less intense (χ2=6.4, p=0.011). THCV in combination with THC significantly increased memory intrusions ( Z=-2.155, p=0.031). Conclusion: In this first study of THC and THCV, THCV inhibited some of the well-known effects of THC, while potentiating others. These findings need to be interpreted with caution due to a small sample size and lack of THC-induced psychotomimetic and memory-impairing effect, probably owing to the choice of dose.
A single dose of mirtazapine attenuates neural responses to self-referential processing
Authors: Komulainen Emma , Heikkilä Roope , Meskanen Katarina , Raij Tuukka T , Nummenmaa Lauri , Lahti Jari , Jylhä Pekka , Melartin Tarja , Harmer Catherine J , Isometsä Erkki , Ekelund Jesper 
Published: November 2015

Increased self-focus is a core factor in the psychopathology of depression. Cortical midline structures (CMS) are implicated in the neurobiology of self, depression and antidepressant treatment response. Mirtazapine, an antidepressant that increases serotonin and norepinephrine release, enhances processing of positive and attenuates processing of negative emotional information in healthy volunteers after a single dose. These early changes, which are opposite to the negative information bias in depression, may be important for the therapeutic effect of mirtazapine. It nevertheless remains unresolved whether/how mirtazapine specifically influences processing of self-referential emotional information. Half of the healthy volunteers ( n=15/30) received a single dose of mirtazapine, in an open-label design, two hours before functional magnetic resonance imaging (fMRI), and the other half was scanned as a control group without medication. During fMRI the participants categorized positive and negative self-referential adjectives. Mirtazapine attenuated responses to self-referential processing in the medial prefrontal cortex and the anterior cingulate cortex. Mirtazapine further decreased responses to positive self-referential processing in the posterior cingulate cortex and parietal cortex. These decreased responses of the CMS suggest that mirtazapine may rapidly improve the ability of the CMS to down-regulate self-referential processing. In depressed patients, this could lead to decreased self-focus and rumination, contributing to the antidepressant effect.
Blood lactate levels as a biomarker of antipsychotic side effects in patients with schizophrenia
Authors: Elmorsy Ekramy , Shahda Mohamed , Mahmoud El-Hassanen M , Rakha Shirien A , Shoaib Mohammed 
Published: November 2015

Background: Antipsychotic drugs (APs) are widely prescribed in psychiatry primarily for the treatment of psychosis in schizophrenia and bipolar disorders. An issue related to poor prognosis in patients with chronic illness relates to the accumulation of lactate levels in blood, leading to patients that become critically ill. It is suggested that haloperidol and olanzapine, as common therapy for schizophrenia, are associated with increased levels of blood lactate, which may contribute towards the extra-pyramidal side effects. Aims and method: In this study, 88 patients attending the psychiatry outpatient clinic of Mansoura University Hospital, under treatment with typical APs (chlorpromazine or haloperidol) or the atypical APs (risperidone, olanzapine or quetiapine) were followed over a three-month period. Blood lactate levels were assessed at diagnosis, ten days and 90 days after the start of AP treatment. Extra-pyramidal symptoms (EPSs) were studied in participants during the course of this study. Results: Chlorpromazine and haloperidol caused significant increases in lactate levels within the first ten days of therapy, while after 90 days, all APs showed significant increases in arterial blood lactate levels in comparison with the first baseline measurement (for all APs, p-values <0.0001). Dystonia was reported by patients on chlorpromazine, haloperidol and risperidone therapies, while Parkinsonian-like manifestations were reported with all APs tested except for quetiapine. Both dystonia and Parkinsonian-like manifestations were also observed alongside the significant increases in arterial blood lactate levels in comparison to patients on therapy not displaying EPSs. Conclusion: These findings suggest elevated blood lactate levels may serve as early biomarkers for occurrence of extra-pyramidal symptoms in patients on chronic APs treatment.
Outcomes of Tibiotalocalcaneal Arthrodesis Through a Posterior Achilles Tendon–Splitting Approach
Authors: Pellegrini Manuel J. , Schiff Adam P. , Adams Samuel B. , DeOrio James K. , Easley Mark E. , Nunley James A. 
Published: November 2015

Background: A number of operative approaches have been described to perform a tibiotalocalcaneal (TTC) arthrodesis. Here we present the largest reported series of a posterior Achilles tendon–splitting approach for TTC fusion. Methods: With institutional review board approval, a retrospective review of the TTC fusions performed at a single academic institution was carried out. Orthopedic surgeons specializing in foot and ankle surgery performed all procedures. Eligible patients included all those who underwent a TTC fusion via a posterior approach and had at least a 2-year follow-up. Forty-one patients underwent TTC arthrodesis through a posterior Achilles tendon–splitting approach. Mean age at surgery was 56.9±15.0 years. There were 21 female and 20 male patients. Preoperative diagnoses included arthritis (n = 13 patients), failed total ankle arthroplasty (9), avascular necrosis of the talus (9), prior nonunion of the ankle and/or subtalar joint (6), Charcot neuro-arthropathy (2), and stage IV flatfoot deformity (2). In 37 patients (90.2%), a hindfoot intramedullary arthrodesis nail was used, with posterior plate or supplemental screw augmentation in 17 patients. Posterior plate stabilization alone was utilized in 4 cases (9.8%). Results: The fusion rate was 80.4%. Eight patients developed a nonunion of the subtalar, tibiotalar, or both joints. Complications were observed in 17 patients (41.4%). Of these, ankle nonunion (19.5%), tibial stress fracture (17%), postoperative cellulitis and superficial wound breakdown (9.7%), subtalar nonunion (4.8%), and TTC malunion (2.4%) were the most frequently identified. One patient eventually underwent amputation (2.4%). Conclusion: We believe that posterior Achilles tendon–splitting approach for tibiotalocalcaneal arthrodesis was a safe and effective method, with similar union and complications rates to some previously described techniques. We believe the posterior approach is advantageous as it provides simultaneous access to both the ankle and subtalar joints and allows for dissection to occur between angiosomes, which may preserve blood supply to the skin. Level of Evidence: Level IV, retrospective case series.
Return to Sports and Physical Activities After the Modified Lapidus Procedure for Hallux Valgus in Young Patients
Authors: MacMahon Aoife , Karbassi John , Burket Jayme C. , Elliott Andrew J. , Levine David S. , Roberts Matthew M. , Deland Jonathan T. , O’Malley Martin J. , Yu Jeanne , Mancuso Carol A. , Ellis Scott J. 
Published: November 2015

Background: The modified Lapidus procedure has successfully relieved pain and corrected deformity in patients with hallux valgus, but its effect on participation in specific sports and physical activities remains unclear. Our goals were to assess sports and physical activities in young patients following the modified Lapidus procedure and to compare these with clinical outcomes. Methods: Fifty-eight eligible patients were identified from a retrospective registry review. Of these, 48 (83%) were reached for follow-up at a mean of 2.8 (range, 1.0 to 6.1) years and had a mean age at surgery of 37.3 (range, 14.1 to 49.3) years. Physical activity participation was evaluated with a new sports-specific, patient-administered questionnaire. Clinical outcomes were evaluated with the Foot and Ankle Outcome Score (FAOS) and compared to sports outcomes. Results: Patients participated in 26 different physical activities, consisting of 212 total physical activities preoperatively and 209 total postoperatively. The most common were walking, running, bicycling, and swimming. Compared to preoperatively, patients rated 29% of activities as less difficult, 52% as the same, and 19% as more difficult and rated participation levels as improved in 40%, the same in 41%, and impaired in 19%. Eighty-one percent of patients were satisfied with their operative outcome in regard to return to physical activity. Changes in the FAOS Pain subscore were significantly associated with improvements in physical activity difficulty ( P < .05), and changes in the Pain, Sports, and QOL subscores were significantly associated with changes in physical activity participation levels ( P < .05). Conclusion: Four in 5 patients were able to participate in previous sports and physical activities, including high-impact activities, at their preoperative participation level or better after the modified Lapidus procedure, and were satisfied with surgery in regard to return to previous activity. However, several patients had increased difficulty and impaired participation in physical activity postoperatively. Altogether, this suggests that the procedure is a viable treatment option for hallux valgus in young, active patients. Level of Evidence: Level IV, retrospective case series.
Hodgkin lymphoma in children and adolescents: improving the therapeutic index
Authors: Kelly Kara M. 
Published: November 2015

Abstract
Hodgkin lymphoma (HL) is a highly curable form of childhood cancer, with estimated 5 year survival rates exceeding 98%. However, the establishment of a “standard of care” approach to its management is complicated by the recognition that long-term overall survival declines in part from delayed effects of therapy and that there continue to be subgroups of patients at risk for relapse for which prognostic criteria cannot adequately define. This challenge has resulted in the development of various strategies aimed at identifying the optimal balance between maintaining overall survival and avoidance of long-term morbidity of therapy, often representing strategies quite different from those used for adults with HL. More precise risk stratification and methods for assessing the chemosensitivity of HL through imaging studies and biomarkers are in evolution. Recent advances in the understanding of the biology of HL have led to the introduction of targeted therapies in both the frontline and relapsed settings. However, significant barriers exist in the development of new combination therapies, necessitating collaborative studies across pediatric HL research consortia and in conjunction with adult groups for the adolescent and young adult (AYA) population with HL.
Eliminating minimal residual disease as a therapeutic end point: working toward cure for patients with CLL
Authors: Thompson Philip A. , Wierda William G. 
Published: November 2015

Abstract
Deep remission and prolonged disease-free survival can be achieved with first-line chemoimmunotherapy (CIT), such as combined fludarabine, cyclophosphamide, and rituximab, in the majority of patients with chronic lymphocytic leukemia (CLL). More modest results are reported with less intense regimens like obinutuzumab plus chlorambucil. Clinical assessment has limited sensitivity in detecting residual disease responsible for subsequent relapse, even including morphologic bone marrow (BM) evaluation. Multicolor flow cytometry and polymerase chain reaction (PCR)-based methods can detect minimal residual disease (MRD) to a sensitivity of ≥1:10 000 (10−4). Achieving BM MRD-negative complete remission (CR) is associated with superior progression-free survival (PFS) and overall survival; MRD status is the single best posttreatment predictor of long-term outcomes after CIT. Newer oral B-cell receptor signaling pathway inhibitors are highly effective at controlling disease, but best monotherapy responses are typically partial remission, and patients must remain on treatment to maintain disease control. Therapeutic progress is still needed for CLL. We propose that targeting MRD provides opportunity to realize this progress. Achieving BM MRD-negative CR is a prerequisite for long-term unmaintained disease-free survival and potential for cure. We review available methodologies for detecting MRD and correlations with posttreatment outcomes. We discuss the potential utility of MRD to direct individualized therapy. Finally, we discuss the importance of MRD-negative status as a surrogate marker for longer PFS in clinical studies to allow more rapid determination of clinical benefit.