bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands
Authors: Suckling Richard J , Korona Boguslawa , Whiteman Pat , Chillakuri Chandramouli , Holt Laurie , Handford Penny A , Lea Susan M 
Published: June 2017

AbstractRecent data have expanded our understanding of Notch signalling by identifying a C2 domain at the N‐terminus of Notch ligands, which has both lipid‐ and receptor‐binding properties. We present novel structures of human ligands Jagged2 and Delta‐like4 and human Notch2, together with functional assays, which suggest that ligand‐mediated coupling of membrane recognition and Notch binding is likely to be critical in establishing the optimal context for Notch signalling. Comparisons between the Jagged and Delta family show a huge diversity in the structures of the loops at the apex of the C2 domain implicated in membrane recognition and Jagged1 missense mutations, which affect these loops and are associated with extrahepatic biliary atresia, lead to a loss of membrane recognition, but do not alter Notch binding. Taken together, these data suggest that C2 domain binding to membranes is an important element in tuning ligand‐dependent Notch signalling in different physiological contexts.
Efficacy of lenvatinib in a patient with anaplastic thyroid cancer
Authors: Oishi Kazuyuki , Takabatake Daisuke , Shibuya Yuichi 
Published: June 2017

Summary
We experienced a case of an 82-year-old woman who presented to our hospital with a 1-month history of dysphagia and dyspnea. Cervical contrast-enhanced computed tomography revealed diffuse thyroid neoplasms causing significant tracheal stenosis with tumors, particularly of the superior mediastinum, which were associated with an embolism of the brachiocephalic vein and suspected invasion to the bilateral common carotid arteries. Anaplastic thyroid cancer (ATC) was diagnosed by fine-needle aspiration; thus, emergency tracheostomy and gastrostomy were performed. We made a definitive diagnosis of ATC (T4bN0M0 Stage IVB) and initiated continuous lenvatinib administration at 24 mg/day. Although several adverse events occurred, the tumor size reduced remarkably over a short period. However, the patient died from rupture of the common carotid artery 30 days after treatment initiation. Here, we report our experience with lenvatinib therapy for ATC and include a literature review.

Learning points:

Lenvatinib is extremely effective for ATC.

Lenvatinib has a much greater cytoreductive effect than traditional therapies, but it needs dose reduction or withdrawal because of treatment-related side effects.

Lenvatinib may cause treatment-related carotid blowout syndrome, resulting in death for patients with invasion to the carotid artery.
SATISFACCIÓN LABORAL Y EL CLIMA ORGANIZACIONAL DE LAS PRINCIPALES UNIVERSIDADES SUCREÑAS
Authors: Rojas Martinez Claudia Patricia 
Published: June 2017

El presente artículo es resultado de una investigación que se realizó con el objetivo describir los elementos que conforman la satisfacción laboral y determinar cómo este factor influye en el clima organizacional de los empleados de las principales universidades sucreñas; la investigación se llevó a cabo en las principales universidades de Sucre (Colombia) que cuentan con sede propia tomándose para ello una muestra de 120 docentes.. Los resultados referentes a las condiciones laborales no son las mejores, además con respecto a la estabilidad laboral, no se garantiza a los colaboradores su permanencia en la organización; con relación a la autorrealización, no hay apoyo suficiente para su crecimiento profesional y las capacitaciones son. Para dar solución a dicha situación se concluye que es necesario implementar estrategias direccionadas a brindar más motivación a los colaboradores organizando capacitaciones de acuerdo al desempeño que se quiera fortalecer en cada docente de esta manera se fundamentar así el clima organizacional y la satisfacción laboral factores que determinen el grado de bienestar de los individuos. ABSTRACTThis article has as objective to describe the elements that make up the job satisfaction and determine how this factor influences the organizational climate of the employees of the main universities sucreñas; the research was conducted at major universities with its own headquarters of the department of Sucre, taking a sample of 120 teachers. Regarding working conditions are not the best, and with respect to job security is not guaranteed to reviewers their stay in the organization in relation to the self, there is sufficient support for their professional growth and training are scarce. To provide a solution to these situations it is concluded that it is very necessary to implement strategies routed to provide more motivation to the collaborators, constantly training according to the performance that you want to strengthen in each teacher and in this way substantiate to the organizational climate and job satisfaction as factors that determine the degree of well-being that the individual experience.
Narrativa de la Memoria como elemento de formación comunitaria en una población de Quito
Authors: Campo Araúz Lorena 
Published: June 2017

<p>En este texto se presentan las reflexiones generadas a partir de la experiencia del proyecto de investigación <em>La memoria como elemento de formación comunitaria en Lloa</em>, de la Universidad Politécnica Salesiana. Se muestran distintas narrativas registradas entre la población del sector y algunas reflexiones alrededor de ellas desde la propuesta de Maurice Halbwachs y Henri Bergson, de manera que quienes lo revisen puedan reflexionar sobre las distintas narrativas registradas alrededor del tema del suicidio y las implicaciones ético-políticas que implica un proceso de investigación de este tipo. Al final, se reconoce que sobre Lloa existen narrativas contenidas en memorias plurales. Cada relato va conformando el sentido comunitario, real e imaginado de la zona con múltiples formas de relatar y construir las memorias de un pueblo marcado por la cercanía al volcán Guagua Pichincha y últimamente la sombra del suicidio.</p>
LA RENOVACIÓN DE LAS IZQUIERDAS EN COLOMBIA: ¿UNA CUESTIÓN DE JÓVENES? Reflexiones desde la política del acontecimiento.
Authors: Forero Nicolás Aguilar 
Published: June 2017

<p>En el presente artículo de reflexión se retoman los planteamientos de Mauricio Lazzarato en torno a la lógica de la diferencia y la política del acontecimiento para destacar su importancia en el camino hacia la renovación de las izquierdas en Colombia. De igual forma, se argumenta que los procesos de renovación de las izquierdas en este país en lugar de orientarse hacia la búsqueda de la unidad y el éxito en la política electoral, pueden nutrirse de las experiencias de acción colectiva juvenil que desde el año 2011 han desplegado formas de organización y relacionamiento alternativas, en donde la comunicación, la confianza, la colaboración y la construcción de lo común han desempeñado un rol crucial. </p>
A Comunicação do Governo Migliorini em Chapecó (1983-1988) a partir das capas do jornal Diário da Manhã
Authors: Vicenzi Liziane Nathália , Dalbosco Vagner 
Published: June 2017

<p class="Standard"><span>O presente artigo é a conclusão da segunda etapa de uma pesquisa que teve como objetivo analisar o governo do ex-prefeito de Chapecó Ledônio Faustino Migliorini, de 1983 a 1988, a partir das capas do jornal Diário da Manhã. A metodologia da pesquisa consistiu em uma análise de conteúdo por amostra de semana composta, com análise de 147 edições do periódico. As edições resultaram em 176 conteúdos identificando como se deu a presença do governo no jornal, os temas e a ênfase dada às pautas relacionadas ao governo. Os resultados obtidos demonstraram que o jornal foi determinante para a construção da Imagem Pública do Governo Migliorini, configurando-se como um aliado na exposição predominantemente positiva das ações da administração pública e na promoção pessoal do prefeito. </span></p>
Spinal epidural hematomas: personal experience and literature review of more than 1000 cases
Authors: Domenicucci Maurizio , Mancarella Cristina , Santoro Giorgio , Dugoni Demo Eugenio , Ramieri Alessandro , Arezzo Maria Felice , Missori Paolo 
Published: June 2017

OBJECTIVEThe goal of this study was to identify factors that contribute to the formation of acute spinal epidural hematoma (SEH) by correlating etiology, age, site, clinical status, and treatment with immediate results and long-term outcomes.METHODSThe authors reviewed their series of 15 patients who had been treated for SEH between 1996 and 2012. In addition, the authors reviewed the relevant international literature from 1869 (when SEH was first described) to 2012, collecting a total of 1010 cases. Statistical analysis was performed in 959 (95%) cases that were considered valid for assessing the incidence of age, sex, site, and clinical status at admission, correlating each of these parameters with the treatment results. Statistical analysis was also performed in 720 (71.3%) cases to study the incidence of etiological factors that favor SEH formation: coagulopathy, trauma, spinal puncture, pregnancy, and multifactorial disorders. The clinical status at admission and long-term outcome were studied for each group. Clinical status was assessed using the Neuro-Grade (NG) scale.RESULTSThe mean patient age was 47.97 years (range 0–91 years), and a significant proportion of patients were male (60%, p < 0.001). A bimodal distribution has been reported for age at onset with peaks in the 2nd and 6th decades of life. The cause of the SEH was not reported in 42% of cases. The etiology concerned mainly iatrogenic factors (18%), such as coagulopathy or spinal puncture, rather than noniatrogenic factors (29%), such as genetic or metabolic coagulopathy, trauma, and pregnancy. The etiology was multifactorial in 11.1% of cases. The most common sites for SEH were C-6 (n = 293, 31%) and T-12 (n = 208, 22%), with maximum extension of 6 vertebral bodies in 720 cases (75%). At admission, 806 (84%) cases had moderate neurological impairment (NG 2 or 3), and only lumbar hematoma was associated with a good initial clinical neurological status (NG 0 or 1). Surgery was performed in 767 (80%) cases. Mortality was greater in patients older than 40 years of age (9%; p < 0.01). Sex did not influence any of these data (p > 0.05).CONCLUSIONSFactors that contribute to the formation of acute SEH are iatrogenic, not iatrogenic, or multifactorial. The treatment of choice is surgery, and the results of treatment are influenced by the patient’s clinical and neurological status at admission, age, and the craniocaudal site.
Reoperation after failed resective epilepsy surgery in children
Authors: Muthaffar Osama , Puka Klajdi , Rubinger Luc , Go Cristina , Snead O. Carter , Rutka James T. , Widjaja Elysa 
Published: June 2017

OBJECTIVEAlthough epilepsy surgery is an effective treatment option, at least 20%–40% of patients can continue to experience uncontrolled seizures resulting from incomplete resection of the lesion, epileptogenic zone, or secondary epileptogenesis. Reoperation could eliminate or improve seizures. Authors of this study evaluated outcomes following reoperation in a pediatric population.METHODSA retrospective single-center analysis of all patients who had undergone resective epilepsy surgery in the period from 2001 to 2013 was performed. After excluding children who had repeat hemispherotomy, there were 24 children who had undergone a second surgery and 2 children who had undergone a third surgery. All patients underwent MRI and video electroencephalography (VEEG) and 21 underwent magnetoencephalography (MEG) prior to reoperation.RESULTSThe mean age at the first and second surgery was 7.66 (SD 4.11) and 10.67 (SD 4.02) years, respectively. The time between operations ranged from 0.03 to 9 years. At reoperation, 8 patients underwent extended cortical resection; 8, lobectomy; 5, lesionectomy; and 3, functional hemispherotomy. One year after reoperation, 58% of the children were completely seizure free (International League Against Epilepsy [ILAE] Class 1) and 75% had a reduction in seizures (ILAE Classes 1–4). Patients with MEG clustered dipoles were more likely to be seizure free than to have persistent seizures (71% vs 40%, p = 0.08).CONCLUSIONSReoperation in children with recurrent seizures after the first epilepsy surgery could result in favorable seizure outcomes. Those with residual lesion after the first surgery should undergo complete resection of the lesion to improve seizure outcome. In addition to MRI and VEEG, MEG should be considered as part of the reevaluation prior to reoperation.
Low Frequency Quasi-periodic Oscillations in the High-eccentric LMXB Cir X-1: Extending the WK Correlation for Z Sources
Authors: Bu Qingcui , Belloni T. M. , Chen Li , Qu Jinlu 
Published: June 2017

Abstract
Using archival Rossi X-ray Timing Explorer (RXTE) data, we studied the low-frequency quasi-periodic oscillations (LFQPOs) in the neutron star low-mass X-ray binary (LMXB) Cir X-1 and examined their contribution to frequency–frequency correlations for Z sources. We also studied the orbital phase effects on the LFQPO properties and found them to be phase independent. Comparing LFQPO frequencies in different classes of LMXBs, we found that systems that show both Z and atoll states form a common track with atoll/BH sources in the so-called WK correlation, while persistent Z systems are offset by a factor of about two. We found that neither source luminosity nor mass accretion rate is related to the shift of persistent Z systems. We discuss the possibility of a misidentification of fundamental frequency for horizontal branch oscillations from persistent Z systems and interpreted the oscillations in terms of models based on relativistic precession.
L’éducation populaire, une voie féconde pour « démocratiser la démocratie » ?
Authors: Roy Alex 
Published: June 2017

À l’heure où l’éducation populaire se questionne sur sa visée émancipatrice et de transformation sociale, l’étude ethnologique d’un de ses acteurs historiques – ATD (Agir tous pour la dignité) Quart monde – est pertinente. En effet, cette association qui lutte contre la pauvreté est l’un des artisans d’une démocratie communicative expérimentant des dispositifs qui visent une participation effective des « exclus » à la délibération. À partir d’un processus de double transformation des « exclus » et des « inclus », ATD Quart monde contribue ainsi à l’effort de « démocratisation de la démocratie ».
Emprise du père et déni du féminin Quand le travail du féminin féconde la rêverie du groupe
Authors: Bécar Florence 
Published: June 2017

Dans ce récit d’une thérapie en couple, l’auteur alterne récits cliniques et analyses théoriques élaborées dans l’après-coup. Les questions ayant servi d’étayage à sa rêverie ont permis la métabolisation du matériel psychique apporté et favorisé la recherche d’une voie de dégagement par le couple enfermé dans un fonctionnement mortifère. Cette voie fut rendue possible par la rêverie du groupe patients/thérapeute ayant engendré sa mise au travail, sa fécondité, sa créativité. L’auteur formule l’hypothèse que la demande initiale présentée comme relevant d’un « problème de communication » serait le précipité d’une soumission à l’emprise paternelle et à son refus du féminin verrouillant la circulation de la parole. L’étayage du groupe constitué par le couple et la clinicienne, leur rêverie féconde et leur mise au travail les ont conduits à élaborer la structuration de l’origine et le défaut de son organisation lié au secret.
Appréhender les transformations organisationnelles de la santé numérique à partir des perceptions des acteurs
Authors: Habib Johanna , Béjean Mathias , Dumond Jean-Paul 
Published: June 2017

Le développement des usages de la santé numérique est appréhendé actuellement comme une source de transformation du système de santé pouvant remodeler substantiellement son fonctionnement. Fondée sur un questionnaire s’adressant aux professionnels du système de santé, cette recherche analyse les transformations organisationnelles de la santé numérique à partir des perceptions des acteurs relatives aux usages souhaités de ces dispositifs technologiques dans les modalités de prise en charge des patients et de gestion du risque. Pour étudier ces perceptions dans une perspective transformationnelle, notre analyse se fonde sur une grille de lecture encore peu utilisée en systèmes d’information : le modèle « Marché, Hiérarchie et Communauté » de Paul S. Adler (Adler, 2001 ; Adler et al., 2008). Structuré autour des grands idéaux-types de l’action organisée, ce modèle constitue un canevas théorique intéressant pour interroger les acteurs sur les orientations des transformations organisationnelles associées à l’usage de nouvelles technologies. Notre recherche se propose de répondre aux questions suivantes : quelles sont les perceptions des professionnels du système de santé quant aux usages souhaités de la santé numérique ? Existe-t-il une perception dominante ou encore des tensions entre plusieurs perceptions d’usages ? Comment ces perceptions permettent-elles d’éclairer les transformations organisationnelles de la santé numérique, ainsi que les sources d’inertie associées ? La principale contribution de cette recherche est de proposer une analyse de l’espace de choix des acteurs en situation de transformation à partir de leurs perceptions des usages souhaités des dispositifs technologiques. L’analyse de ces perceptions d’usages permet, en effet, de se projeter dans des situations anticipées de transformation, reliant ainsi les niveaux micro (les professionnels), méso (les organisations) et macro (le système de santé) d’un processus de changement.
Groupe thérapeutique d’enfants confiés à la mission de protection de l’enfance par la justice : une méthodologie systémique en CAMSP
Authors: Legendre Christian 
Published: June 2017

Les jeunes enfants (moins de 6 ans) confiés par les juges des enfants aux conseils départementaux au titre de la protection de l’enfance vivent la plupart du temps dans des familles d’accueil et rencontrent leur famille biologique tantôt avec une médiation, tantôt sans. Ils sont donc inclus dans des systèmes à double parentalité. Ils présentent par ailleurs fréquemment des troubles qui les amènent à consulter des établissements médico-sociaux comme les CAMSP. Leur « prise en charge » thérapeutique individuelle se heurte régulièrement à des difficultés importantes et piétine : ils sont en effet rarement en mesure d’élaborer une demande d’aide psychologique individuelle. Les demandeurs sont ailleurs (assistants familiaux, référents des pôles placement familial, école). L’auteur propose et décrit un dispositif thérapeutique groupal systémique, élaboré et mis en œuvre dans un CAMSP. Ce dispositif s’adresse aux enfants, à leurs assistants familiaux, à leurs familles biologiques (indirectement), à leurs référents du conseil départemental. Une vignette clinique illustre le propos.
Links or disconnect: a first consideration of inflation expectations and inflation credibility, with specific reference to South Africa
Authors: Rossouw Jannie , Padayachee Vishnu , Bosch Adel 
Published: June 2017

This paper compares international and domestic inflation expectations and inflation credibility, and hypothesises about a possible link or disconnect between inflation expectations and inflation credibility among South Africans. No similar tests have previously been performed using South African data, and there is also a general lack of domestic and international literature on any such possible link or disconnect. While research shows that inflation expectations are taken into account by all countries targeting inflation, inflation credibility is very seldom considered. Although the hypothesis is confirmed in certain instances, it is refuted by a disconnect between the inflation expectations and inflation credibility of male and female respondents in South Africa, which cannot be explained by available data.
Socio-demographic and behavioural determinants of visitor spending at the Kruger National Park in South Africa
Authors: Saayman Andrea , Saayman Melville 
Published: June 2017

The Kruger National Park is one of the most visited national parks in the world and one of South Africa’s prime tourism destinations. It attracts more than 1 million visitors per year and, as such, plays an important role in the regional and national economy. The article aims to assess the extent to which socio-demographic and behavioural indicators influence the spending of tourists to the Park. From 2001-2007 surveys have been conducted amongst tourists to the Park including a number of socio-demographic, behavioural and motivational questions, totalling 2 904 questionnaires used in the analysis. The methodology includes both cross-sectional regression analysis and pseudo-panel data analysis to identify and compare possible influences on spending. Findings indicate that, even though a combination of socio-demographic, behavioural and motivational factors influence spending at National Parks, behavioural indicators seem to be the most important and consistent influencer.
Demographics and consumer ethnocentrism in a developing context: A South African study
Authors: Pentz Chris D , Terblanche Nic S , Boshoff Christo 
Published: June 2017

The continued growth in international trade results in the fact that consumers in many countries are exposed to increasing amounts of product offerings from various countries of origin. As the origin of products might have an influence on consumer behavior, many marketers realize that extended knowledge on consumer behavior toward both domestic and imported products can be useful in the formulation of more effective marketing strategies. Past research in the field of international marketing suggest that the concept of consumer ethnocentrism can be an influencing factor in the decision of consumers to purchase locally-produced rather than imported products. While the concept of consumer ethnocentrism has been actively researched in a number of contexts and countries, research on this phenomenon has been limited in developing countries. The present study aims to add to the existing body of knowledge on consumer ethnocentrism in developing markets by investigating the possible relationships between consumer ethnocentrism and a number of demographic variables in South Africa. A unique contribution of this study is that the investigation focused on two different samples in terms of race, namely on a sample of “white” respondents and a sample of “black” respondents to account for the ethnic diversity in South Africa. The results of the study revealed that for both groups of respondents there was a positive relationship between age and consumer ethnocentrism, while a negative relationship was found for both groups in terms of the relationship between consumer ethnocentrism and income. In terms of the relationship between consumer ethnocentrism and gender, the results differed between the two groups of respondents. The findings can be used rewardingly by marketers wishing to operate more successfully in developing markets, such as South Africa.
Software piracy – Some aspects for South African managers to keep in mind
Authors: De Kock D , Lubbe S , Kritzinger W 
Published: June 2017

Software piracy is a significant issue for managers of organisations, especially in developing countries. There are several factors which contribute to software piracy, and which are investigated in this study. This study consists of a literature review, and reports on empirical research, which was conducted using a survey instrument to determine if software piracy is prevalent in South Africa. The findings confirm the results of previous studies. The conclusion is made that software piracy will always exist and that stricter measures are needed to prevent its occurrence.