bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective and effective targeting of chronic myeloid leukemia stem cells by topoisomerase II inhibitor etoposide in combination with imatinib mesylate in vitro
Authors: Liu Man‐Yu , Wang Wei‐Zhang , Liao Fen‐Fang , Wu Qing‐Qing , Lin Xiang‐Hua , Chen Yong‐Hen , Cheng Lin , Jin Xiao‐Bao , Zhu Jia‐Yong 
Published: September 2016

AbstractImatinib mesylate (IM) and other BCR‐ABL tyrosine kinase inhibitors (TKIs) have improved chronic myeloid leukemia (CML) patient survival markedly but fail to eradicate quiescent CML leukemia stem cells (LSCs). Thus, strategies targeting LSCs are required to induce long‐term remission and achieve cure. Here, we investigated the ability of topoisomerase II (Top II) inhibitor etoposide (Eto) to target CML LSCs. Treatment with Eto combined with IM markedly induced apoptosis in primitive CML CD34+CD38− stem cells resistant to eradication by IM alone, but not in normal hematopoietic stem cells, CML and normal mature CD34− cells, and other leukemia and lymphoma cell lines. The interaction of IM and Eto significantly inhibited phosphorylation of PDK1, AKT, GSK3, S6, and ERK proteins; increased the expression of pro‐apoptotic gene Bax; and decreased the expression of anti‐apoptotic gene c‐Myc in CML CD34+ cells. Top II inhibitors treatment represents an attractive approach for targeting LSCs in CML patients undergoing TKIs monotherapy.
A Ferrocenyl‐Benzo‐Fused Imidazolylidene Complex of Ruthenium as Redox‐Switchable Catalyst for the Transfer Hydrogenation of Ketones and Imines
Authors: Ibáñez Susana , Poyatos Macarena , Peris Eduardo 
Published: September 2016

AbstractA ferrocenyl‐benzo‐fused imidazolylidene complex of RuII was prepared and fully characterized. In the presence of acetylferrocenium tetrafluoroborate this complex can be oxidized to generate a complex with a cationic ligand. The neutral complex can be recovered by reducing the oxidized cationic compound with cobaltocene. The activity of the neutral and oxidized complexes was tested in the transfer hydrogenation of ketones and imines, using isopropyl alcohol as the hydrogen source. The neutral complex is very active in the reduction of all tested substrates, whereas the oxidized species shows low activity in the reduction of ketones. The rate of the reduction of hexaphenone could be modulated by addition of subsequent amounts of oxidant and reductant. The addition of acetylferrocenium tetrafluoroborate caused a decrease in the catalytic activity, whereas the addition of cobaltocene restored the activity. The catalytic activity shown by both catalysts in the reduction of N‐benzylideneaniline was similar.
Efficient Self‐Contained Photoacid Generator System Based on Photochromic Terarylenes
Authors: Li Ruiji , Nakashima Takuya , Kanazawa Rui , Galangau Olivier , Kawai Tsuyoshi 
Published: September 2016

AbstractA series of highly sensitive neutral photoacid generators (PAGs) based on photochromic terarylenes was prepared. Like the example presented herein, these compounds show a subsequent thermal elimination of a Brønsted acid after a light‐triggered 6π‐electrocyclization, concomitant with the hexatriene aromatization. A novel type of molecular systems was developed, in which one thiazolyl moiety was replaced by a thienyl group. Depending on the solvents and on the nature of the acid source, the quantum yield (QY) for acid generation could reach up to 0.6. Comparative studies on the acid source clearly showed that aromatic leaving groups tend to extinguish the molecular system photoefficiency. A second type was also prepared, in which the nature of the hetero‐aromatic rings were identical to our previous example, but their sequence was modified. Therefore, a second level of improvement was achieved in nonpolar solvents, pushing the QY value up to 0.7. Finally, we demonstrated the mesylic acid‐releasing PAG as a photocatalyst in a chemically amplified positive resist system.
ChemInform Abstract: Crystallization of LiAlSiO4 Glass in Hydrothermal Environments at Gigapascal Pressures—Dense Hydrous Aluminosilicates.
Authors: Spektor Kristina , Fischer Andreas , Haeussermann Ulrich 
Published: September 2016

AbstractCrystallization of the title glass is investigated in the presence of a large excess of water in the pressure range of 0.25—10 GPa and at temperatures from 200 to 600 °C by powder XRD, SEM, and IR spectroscopy.
ChemInform Abstract: Germanium‐Doped and Germanium/Nitrogen‐Codoped Carbon Nanotubes with Highly Enhanced Activity for Oxygen Reduction in Alkaline Medium.
Authors: Wang Fang , Liu Ziwu , Li Meng , Wang Quan‐De 
Published: September 2016

AbstractThe title nanotubes are prepared by chemical vapor deposition of a xylene or aniline solution of GeEt4 (2, 4 and 8 wt.%) using FeMo/Al2O3 as catalyst (quartz tube, 500→800 °C).
ChemInform Abstract: A Perovskite Electrocatalyst for Efficient Hydrogen Evolution Reaction.
Authors: Xu Xiaomin , Chen Yubo , Zhou Wei , Zhu Zhonghua , Su Chao , Liu Meilin , Shao Zongping 
Published: September 2016

AbstractPolycrystalline A‐site Pr‐doped Prx (Ba0.5Sr0.5) 0.5Co0.8Fe0.2O3‐δ (x = 0—1) is prepared by reaction of the metal nitrates, EDTA, and citric acid in a 1(total metal ions):1:2 molar ratio (1.
ChemInform Abstract: Multivariate Synthesis of Tin Phosphide Nanoparticles: Temperature, Time, and Ligand Control of Size, Shape, and Crystal Structure.
Authors: Tallapally Venkatesham , Esteves Richard J Alan , Nahar Lamia , Arachchige Indika U. 
Published: September 2016

AbstractNarrowly disperse rhombohedral Sn4P3 (I), hexagonal SnP (II), and trigonal Sn3P4 (III) nanoparticles (NPs) are prepared by size‐, shape‐, and phase‐controlled colloidal synthesis.
ChemInform Abstract: Asymmetric Alkylation or Silylation of (S)‐(‐)‐Diphenylprolinol‐Derived α‐Silylamide to Synthesize Optically Pure α‐Monosilyl or Bis(silyl) Amides.
Authors: Huang Zhenggang , Gao Lu , Song Zhenlei 
Published: September 2016

AbstractThe reaction of the (S)‐prolinol derivative (I) with alkyl and disilyl halides proceeds with high diastereoselectivity to give optically pure α‐monosilyl or bissilyl amides.
ChemInform Abstract: Gold‐Catalyzed Photoredox C(sp2) Cyclization: Formal Synthesis of (.+‐.)‐Triptolide.
Authors: Cannillo Alexandre , Schwantje Travis R. , Begin Maxime , Barabe Francis , Barriault Louis 
Published: September 2016

AbstractThe method is applied in the construction of compound (VI), a key intermediate in the total synthesis of (.+‐.)‐triptolide (VII).
ChemInform Abstract: Ligand‐Assisted Palladium(II)/(IV) Oxidation for sp3 C—H Fluorination.
Authors: Sun Huan , Zhang Yi , Chen Ping , Wu Yun‐Dong , Zhang Xinhao , Huang Yong 
Published: September 2016

AbstractThe palladium‐catalyzed fluorination of 3‐phenyl‐N‐(quinolin‐8‐yl)propanamide (I) proceeds readily in the presence of quinoxaline as a ligand.
ChemInform Abstract: UV Light‐Mediated Difunctionalization of Alkenes with CF3SO2Na: Synthesis of Trifluoromethyl Phenanthrene and Anthrone Derivatives.
Authors: Li Bing , Fan Dan , Yang Chao , Xia Wujiong 
Published: September 2016

AbstractThe benzophenone‐catalyzed photoreaction of α,β‐unsaturated ketones affords trifluoromethyl‐containing phenanthrenes, whilst the analogous anthraquinone‐catalyzed reaction of γ,δ‐unsaturated ketones gives rise to trifluoromethylated anthrone derivatives.
ChemInform Abstract: Z‐Selective (Cross‐)Dimerization of Terminal Alkynes Catalyzed by an Iron Complex.
Authors: Rivada‐Wheelaghan Orestes , Chakraborty Subrata , Shimon Linda J. W. , Ben‐David Yehoshoa , Milstein David 
Published: September 2016

AbstractThe homocoupling of terminal alkynes and a cross‐dimerization of aryl alkynes with ethynylsilane affords the corresponding enynes stereoselectively.
ChemInform Abstract: Alternative Protocol for the Synthesis of Symmetrical Dibenzyl Diselenides and Disulfides.
Authors: Panduranga Veladi , Prabhu Girish , Prabhu Basava , Panguluri Nageswara Rao , Sureshbabu Vommina V. 
Published: September 2016

AbstractA one‐pot synthesis of the title compounds from the reaction of the corresponding benzyl alcohols with NaBH2Se3 and NaBH2S3 under mild conditions and short time, respectively, is described.
ChemInform Abstract: Unprecedented Oxidative Addition of Highly Active Manganese into the Oxygen—Sulfur Bond of Coumarin and Pyrone 4‐Tosylates.
Authors: Shin Ueon Sang , Joo Seong‐Ryu , Kim Seung‐Hoi 
Published: September 2016

AbstractOrganomanganese reagents (I) are unexpectedly prepared by the reaction of highly active manganese with tolylsulfonate derivatives.
ChemInform Abstract: A Systematic Study on the Cadiot—Chodkiewicz Cross Coupling Reaction for the Selective and Efficient Synthesis of Hetero‐diynes.
Authors: Chinta Bhavani Shankar , Baire Beeraiah 
Published: September 2016

AbstractUnsymmetrical diynes are highly selectively and efficiently prepared by Cadiot—Chodkiewicz cross coupling reactions between various terminal alkynes and haloalkynes using water as green solvent.
ChemInform Abstract: Ruthenium‐Catalyzed Hydrogenation of Aromatic Amino Acids in Aqueous Solution.
Authors: Sun Bing , Suess‐Fink Georg 
Published: September 2016

AbstractL‐phenylalanine and L‐phenylglycine are converted exclusively into the corresponding L‐cyclohexyl amino acids with retention of chirality and excellent selectivity.
ChemInform Abstract: Oxidative Esterification of Aromatic Aldehydes Using Polymer‐Supported Green Bromine.
Authors: Sridhar A. , Swarnalakshmi S. , Selvaraj M. 
Published: September 2016

AbstractAlkyl benzoates are prepared by a facile, green one‐pot esterification of benzaldehydes using bromine supported on Amberlite IRA‐400 chloride resin as reusable catalyst.
ChemInform Abstract: Cyclic anti‐Azacarboxylation of 2‐Alkynylanilines with Carbon Dioxide.
Authors: Miao Bukeyan , Li Suhua , Li Gen , Ma Shengming 
Published: September 2016

AbstractZnEt2‐mediated cyclization reactions of 2‐alkynylanilines with CO2 provide a wide range of substituted indole‐3‐carboxylic acids.
ChemInform Abstract: Asymmetric [3 + 2] Cycloaddition of Donor—Acceptor Aziridines with Aldehydes via Carbon—Carbon Bond Cleavage.
Authors: Liao Yuting , Liu Xiaohua , Zhang Yu , Xu Yali , Xia Yong , Lin Lili , Feng Xiaoming 
Published: September 2016

AbstractThe protocol allows for the preparation of a broad range of cis‐1,3‐oxazolidines in high yields and with high enantiomeric excesses.
ChemInform Abstract: Palladium‐Catalyzed Highly Chemoselective Intramolecular C—H Aminocarbonylation of Phenethylamines to Six‐Membered Benzolactams.
Authors: Taneda Hiroshi , Inamoto Kiyofumi , Kondo Yoshinori 
Published: September 2016

AbstractA selective intramolecular C—H aminocarbonylation of Br‐functionalized phenethylamines in the presence of carbon monoxide is achieved while leaving the C—Br bond intact to afford six‐membered benzolactams in moderate to high yields.
ChemInform Abstract: A Palladium‐Catalyzed Intramolecular Carbonylative Annulation Reaction for the Synthesis of 4,5‐Fused Tricyclic 2‐Quinolones.
Authors: Zhang Xiwu , Liu Haichao , Jia Yanxing 
Published: September 2016

AbstractThe title reaction of alkyne‐tethered N‐substituted o‐iodoanilines proceeds smoothly under mild conditions and exhibits exceptional tolerance to a variety of functional groups.
ChemInform Abstract: An Efficient Synthesis of Novel Pyridothieno‐Fused Thiazolo[3,2‐a]pyrimidinones via Pictet—Spengler Reaction.
Authors: Wang Dao‐Lin , Wang Dong , Yan Liang , Pan Guang‐Yu , Yang Jian‐Nan 
Published: September 2016

AbstractTitle compounds (V) are efficiently synthesized using a Pictet—Spengler reaction of key intermediate (III), which is obtained by condensation reaction of compound (I) with 3‐cyanopyridine‐2‐thione (II) via Thorpe—Ziegler isomerization, and aromatic aldehydes (IV) under sulfamic acid catalysis in good yields.
ChemInform Abstract: In situ Generation of Dihydropyridine for the Enantioselective Transfer Hydrogenation of 1,4‐Benzoxazines
Authors: Aillerie Alexandre , Gosset Cyrille , Dumont Clement , Skrzypczak Valentin , Champetter Philippe , Pellegrini Sylvain , Bousquet Till , Pelinski Lydie 
Published: September 2016

Abstractleading to enantioenriched dihydrobenzoxazines
ChemInform Abstract: Camphor‐Derived Thioureas: Synthesis and Application in Asymmetric Kabachnik—Fields Reaction.
Authors: Reddy Pogula Sreekanth , Reddy Motakatla Venkata Krishna , Reddy Peddiahgari Vasu Govardhana 
Published: September 2016

Abstractα‐Aminophosphonates (IV) are enantioselectively synthesized through a one‐pot three‐component Kabachnik—Fields reaction between pyrimidin‐4‐carbaldehyde (I), amines (II), and diphenylphosphite (III) catalyzed by an enantiopure camphor‐derived thiourea derivative.
ChemInform Abstract: Probing the Reactivity of H‐Phosphonate Derivatives for the Hydrophosphonylation of Various Alkenes and Alkynes under Free‐Radical Conditions.
Authors: Geant Pierre‐Yves , Mohamed Bemba Sidi , Perigaud Christian , Peyrottes Suzanne , Uttaro Jean‐Pierre , Mathe Christophe 
Published: September 2016

AbstractEfficient hydrophosphonylation of various alkenes and alkynes is achieved under photoinduced free‐radical conditions using 2,2‐dimethoxy‐2‐phenylacetophenone as photoinitiator.
ChemInform Abstract: Steroids from the Rhizome of Anemarrhena asphodeloides and Their Cytotoxic Activities.
Authors: Sun Yu , Wu Jie , Sun Xue , Huang Xiaoxiao , Li Lingzhi , Liu Qingbo , Song ShaoJiang 
Published: September 2016

AbstractFive new steroids, anemarrhena S1‐S5 (I)‐(V), are isolated from the rhizome of Anemarrhena asphodeloides together with seven known ones.
ChemInform Abstract: Antiinflammatory Effects of a Triterpene Glycoside from Fruit of Acanthopanax koreanum in LPS‐Induced RAW 264.7 Cells.
Authors: Kim Jung Eun , Lee Nam Ho 
Published: September 2016

AbstractGlucopyranoside (I) is isolated from the fruit of Acanthopanax koreanum and shown to possess inhibitory effects on inflammatory mediators so that it could have a potential for use as an antiinflammatory agent.
CFD analysis of flow regimes in airlift reactor using Eulerian‐Lagrangian approach
Authors: Pawar Sanjay B. 
Published: September 2016

AbstractThe hydrodynamic aspects of the concentric tube airlift reactor have been studied using two‐phase CFD simulations with a Eulerian‐Lagrangian approach. The three‐dimensional CFD simulations are carried out with the experimental geometry of airlift reactor (H/D = 12) reported in the published literature. The standard k‐ϵ turbulence model is used with additional consideration of production and dissipation of buoyancy‐induced turbulence. Two different bubble size distributions (BSDs) and their Sauter mean diameters have been considered to represent the gas distribution at sparger in the reactor. This study shows that the BSD1 (1–5–10 mm) containing a high fraction of small bubbles (≤ 5 mm) represents the hydrodynamics of flows appropriately as compared to the BSD2 (5–10–15 mm) containing a high fraction of large bubbles (≥ 10 mm) or the single size bubble diameters (5.25 mm and 10 mm). Further, three regimes of operation such as no gas bubbles in the downcomer (regime I), stationary gas bubbles in the downcomer (regime II), and gas bubble recirculation from the downcomer section to the riser section (regime III), are verified using CFD simulations with Lagrangian particle tracking. Satisfactory agreement (within 15 % deviation) with the experimental data was observed for parameters such as the gas holdups in the riser and downcomer and the liquid circulation velocity in the flow regimes I and II for BSD1.
Discovery and Biophysical Evaluation of First Low Nanomolar Hits Targeting CYP125 of M. tuberculosis
Authors: Brengel Christian , Thomann Andreas , Schifrin Alexander , Eberhard Jens , Hartmann Rolf W. 
Published: September 2016

AbstractTuberculosis, which is predominantly caused by Mycobacterium tuberculosis (Mtb), is still the most lethal bacterial infection with 1.5 million casualties in 2014. Moreover, the fact that the appearance of resistant mutants and long‐term treatment are coupled with economic problems in developing countries hampers an efficient therapy. Interference with the essential cholesterol metabolism of Mtb could be a promising novel strategy to fight Mtb infections. CYP125, a P450 enzyme in Mtb, has been shown to play an important role in this metabolic pathway. For this reason, we used a combined screening approach involving surface plasmon resonance spectroscopy and a heme coordination assay to identify new CYP125 binders by employing a focused P450‐inhibitor library. We identified the first hits with high affinity and favorable ligand efficiencies. Furthermore, frontrunner compounds also showed selectivity toward CYP121 specific to Mtb and required for its survival. To date, these are the first compounds targeting CYP125 with low nanomolar affinity.
The treatment of childhood acute lymphoblastic leukemia in Guatemala: Biologic features, treatment hurdles, and results
Authors: Antillón Federico G. , Blanco Jessica G. , Valverde Patricia D. , Castellanos Mauricio , Garrido Claudia P. , Girón Veronica , Letona Tomas R. , Osorio Emilia J. , Borrayo Dyna A. , Mack Ricardo A. , Melgar Mario A. , Lorenzana Rodolfo , Ribeiro Raul C. , Metzger Monika , Conter Valentino , Rossi Emanuela , Valsecchi Maria Grazia 
Published: September 2016

BACKGROUNDThe National Pediatric Oncology Unit (UNOP) is the only pediatric hemato‐oncology center in Guatemala.METHODSPatients ages 1 to 17 years with acute lymphoblastic leukemia (ALL) were treated according to modified ALL Intercontinental Berlin‐Frankfurt‐Münster (IC‐BFM) 2002 protocol. Risk classification was based on age, white blood cell count, immunophenotype, genetics (when available), and early response to therapy.RESULTSFrom July 2007 to June 2014, 787 patients were treated, including 160 who had standard‐risk ALL, 450 who had intermediate‐risk ALL, and 177 who had high‐risk ALL. The induction death rate was 6.6%, and the remission rate was 92.9%. The rates of death and treatment abandonment during first complete remission were 4.8% and 2.5%, respectively. At a median observation time of 3.6 years, and with abandonment considered an event, the 5‐year event‐free survival and overall survival estimates ( ± standard error) were 56.2% ± 2.1% and 64.1% ± 2.1%, respectively, with a 5‐year cumulative incidence of relapse of 28.9% ± 2.0%. Twenty‐one of 281 patients (7.5%) investigated were positive for the ets variant 6/runt‐related transcription factor 1 (ETV6/RUNX1) fusion.CONCLUSIONSA well organized center in a low‐middle‐income country can overcome the disadvantages of malnutrition and reduce abandonment. Outcomes remain suboptimal because of late diagnosis, early death, and a high relapse rate, which may have a partly genetic basis. Earlier diagnosis, better management of complications, and better knowledge of ALL will improve outcomes. Cancer 2017;123:436–448. © 2016 American Cancer Society.
Prolonged survival with a longer duration of maintenance lenalidomide after autologous hematopoietic stem cell transplantation for multiple myeloma
Authors: Mian Idrees , Milton Denái R. , Shah Nina , Nieto Yago , Popat Uday R. , Kebriaei Partow , Parmar Simrit , Oran Betul , Shah Jatin J. , Manasanch Elisabet E. , Orlowski Robert Z. , Shpall Elizabeth J. , Champlin Richard E. , Qazilbash Muzaffar H. , Bashir Qaiser 
Published: September 2016

BACKGROUNDAlthough lenalidomide maintenance therapy has demonstrated improved outcomes after autologous hematopoietic stem cell transplantation (auto‐HCT) for patients with multiple myeloma (MM), the impact of the duration of this therapy is not clearly known.METHODSThis study retrospectively analyzed all MM patients who were placed on maintenance lenalidomide after auto‐HCT between January 2007 and December 2013. Progression‐free survival (PFS) and overall survival (OS) were analyzed in multivariate Cox proportional hazards regression models that included the duration of maintenance as a time‐dependent covariate.RESULTSOf the 464 patients identified, 46% initiated therapy early (<4 months after auto‐HCT). The median PFS and OS were 38 and 78 months, respectively. Improvements in PFS (hazard ratio [HR], 0.13; 95% confidence interval [CI], 0.04‐0.38; P < .001) and OS (HR, 0.09; 95% CI, 0.03‐0.26; P < .001) were seen for those on maintenance for >2 years versus those on maintenance for ≤2 years. For those on maintenance for >3 versus those on maintenance for ≤3 years, this trend continued with improvements seen in PFS (HR, 0.02; 95% CI, 0.00‐0.44; P = .012) and OS (HR, 0.05; 95% CI, 0.00‐0.83; P = .037). The incidence of second primary malignancies (SPMs) in the entire cohort was 3%. No differences were seen in survival between early and late initiators of maintenance lenalidomide.CONCLUSIONSA longer duration of maintenance therapy was associated with longer survival. The incidence of SPMs was low, and they were not associated with the duration of maintenance. The timing of the initiation of maintenance had no effect on survival. Cancer 2016;122:3831–3837. © 2016 American Cancer Society.
Electrochemically‐controlled DNA Release under Physiological Conditions from a Monolayer‐modified Electrode
Authors: Honarvarfard Elham , Gamella Maria , Guz Nataliia , Katz Evgeny 
Published: September 2016

AbstractAn indium tin oxide (ITO) electrode prepared on a flexible polymeric support was modified with an amino‐silane and then functionalized with trigonelline and 4‐carboxyphenylboronic acid covalently bound to the amino groups. The trigonelline species containing quarterized ammonium group produced positive charge on the electrode surface regardless of the pH value, while the phenylboronic acid species were neutral below pH 8 and negatively charged above pH 9 (note that their pKa=8.4). The total charge on the monolayer‐modified electrode was positive at the neutral pH and negative at pH>9 (note that 4‐carboxyphenylboronic acid was attached to the electrode surface in excess to trigonelline, thus allowing the negative charge to dominate on the electrode surface at basic pH). Single‐stranded DNA molecules were loaded on the modified electrode at pH 7.0 due to their electrostatic attraction to the positively charged surface. By applying electrolysis at −1.0 V (vs. Ag/AgCl reference) electrochemical oxygen reduction resulted in the consumption of hydrogen ions and local pH increase in the vicinity of the electrode surface. The process resulted in the transition to the total negative charge due to the negative charges formed on the phenylboronic acid species. This resulted in the electrostatic repulsion and release of the loaded DNA. The developed approach allowed the electrochemically‐triggered DNA release not only in the aqueous solutions, but also in human serum solution, thus giving promise for future biomedical applications.