bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climatic suitability ranking of biological control candidates: a biogeographic approach for ragweed management in Europe
Authors: Sun Yan , Brönnimann Olivier , Roderick George K. , Poltavsky Alexander , Lommen Suzanne T. E. , Müller‐Schärer Heinz 
Published: April 2017

AbstractBiological control using natural antagonists has been a most successful management tool against alien invasive plants that threaten biodiversity. The selection of candidate agents remains a critical step in a biocontrol program before more elaborate and time‐consuming experiments are conducted. Here, we propose a biogeographic approach to identify candidates and combinations of candidates to potentially cover a large range of the invader. We studiedAmbrosia artemisiifolia(common ragweed), native to North America (NA) and invasive worldwide, and sixNAbiocontrol candidates for the introduced Europe (EU) range of ragweed, both under current and future bioclimatic conditions. For the first time, we constructed species distribution models based on worldwide occurrences and important bioclimatic variables simultaneously for a plant invader and its biocontrol candidates in view of selecting candidates that potentially cover a large range of the target invader. Ordination techniques were used to explore climatic constraints of each species and to perform niche overlap tests with ragweed. We show a large overlap in climatic space between candidates and ragweed, but a considerable discrepancy in geographic range overlap betweenEU(31.4%) andNA(83.3%). This might be due to niche unfilling and expansion of ragweed inEUand the fact that habitats with high ragweed occurrences inEUare rare inNAand predicted to be unsuitable for the candidates. Total geographic range of all candidates combined is expected to decrease under climate change in both ranges, but they will respond differently. The relative geographic coverage of a plant invader by biocontrol candidates at home is largely transferable to the introduced range, even when the invader shifts its niche. Our analyses also identified which combination of candidates is expected to cover the most area and for which abiotic conditions to select in order to develop climatically adapted strains for particular regions, where ragweed is currently unlikely to be controlled.
Grassland restoration in northern China is far from complete: evidence from carbon variation in the last three decades
Authors: Ma Anna , He Nianpeng , Xu Li , Wang Qiufeng , Li Meiling , Yu Guirui 
Published: April 2017

AbstractEcosystem restoration requires considering both above‐ground biomass (AGB) and soils, and the latter is even more essential due to the importance and restoration difficulty of soil organic matter (SOM). Remote sensing studies have shown that AGB has recovered in the grasslands of northern China, but the recovery of soil organic carbon (SOC) or SOM is still unclear. Here, based on the published data between the 1980s and 2014, we used the variation in carbon (C) density observed in the vegetation and soils of four regions across northern China as integrative indicator to explore grassland restoration. Overall, northern Chinese grasslands were a weak carbon source (−14 Tg C), although C density in AGB and below‐ground biomass increased on average by 0.019 and 0.224 kg C/m2, respectively, during the period considered in the present study. Unexpectedly, SOC density in the 0–20 cm soil layer decreased by 0.193 kg C/m2 on average, and all regions registered a decrease in SOC, although values differed among them. Our findings were consistent with previous evaluations using remote sensing and with the idea that vegetation in northern China has been restored. However, SOC has not been restored, and given its importance for sustaining nutrient supply and water conservation, as well as the high difficulty of SOC restoration, grassland restoration in northern China is still far from being achieved.
Polyunsaturated fatty acids in fishes increase with total lipids irrespective of feeding sources and trophic position
Authors: Kainz M. J. , Hager H. H. , Rasconi S. , Kahilainen K. K. , Amundsen P.‐A. , Hayden B. 
Published: April 2017

AbstractTrophic transfer and retention of dietary compounds are vital for somatic development, reproduction, and survival of aquatic consumers. In this field study, stable carbon and nitrogen isotopes, and fatty acids (FA) contents in invertebrates and fishes of pre‐alpine Lake Lunz, Austria, were used to (1) identify the resource use and trophic level of Arctic charr (Salvelinus alpinus), pike (Esox lucius), perch (Perca fluviatilis), brown trout (Salmo trutta), roach (Rutilus rutilus), and minnow (Phoxinus phoxinus) and (2) examine how polyunsaturated fatty acids (PUFA; i.e., omega‐3 and ‐6PUFA) are related to total lipid status, littoral–pelagic reliance, and trophic position. Stable isotope data suggest that pike, perch, and minnow derived most of their energy from littoral resources, but minnows differed from pike and perch in their trophic position andPUFAcomposition. The co‐occurrence of cyprinids, percids, and pike segregated these fishes into more lipid‐rich (roach, minnow) and lipid‐poor (pike, percids) species. Although the relatively lipid‐poor pike and percids occupied a higher trophic position than cyprinids, there was a concurrent, total lipid‐dependent decline in omega‐3 and ‐6PUFAin these predatory fishes. Results of this lake food‐web study demonstrated that total lipids in fish community, littoral–pelagic reliance, and trophic position explained omega‐3 and ‐6PUFAin dorsal muscle tissues. Omega‐3 and ‐6PUFAin these fishes decreased with increasing trophic position, demonstrating that these essential FAs did not biomagnify with increasing trophic level. Finally, this lake food‐web study provides evidence of fish community‐level relationship between total lipid status andPUFAor stable isotope ratios, whereas the strength of such relationships was less strong at the species level.
Mechanistic species distribution modeling reveals a niche shift during invasion
Authors: Chapman Daniel S. , Scalone Romain , Štefanić Edita , Bullock James M. 
Published: April 2017

AbstractNiche shifts of nonnative plants can occur when they colonize novel climatic conditions. However, the mechanistic basis for niche shifts during invasion is poorly understood and has rarely been captured within species distribution models. We quantified the consequence of between‐population variation in phenology for invasion of common ragweed (Ambrosia artemisiifolia L.) across Europe. Ragweed is of serious concern because of its harmful effects as a crop weed and because of its impact on public health as a major aeroallergen. We developed a forward mechanistic species distribution model based on responses of ragweed development rates to temperature and photoperiod. The model was parameterized and validated from the literature and by reanalyzing data from a reciprocal common garden experiment in which native and invasive populations were grown within and beyond the current invaded range. It could therefore accommodate between‐population variation in the physiological requirements for flowering, and predict the potentially invaded ranges of individual populations. Northern‐origin populations that were established outside the generally accepted climate envelope of the species had lower thermal requirements for bud development, suggesting local adaptation of phenology had occurred during the invasion. The model predicts that this will extend the potentially invaded range northward and increase the average suitability across Europe by 90% in the current climate and 20% in the future climate. Therefore, trait variation observed at the population scale can trigger a climatic niche shift at the biogeographic scale. For ragweed, earlier flowering phenology in established northern populations could allow the species to spread beyond its current invasive range, substantially increasing its risk to agriculture and public health. Mechanistic species distribution models offer the possibility to represent niche shifts by varying the traits and niche responses of individual populations. Ignoring such effects could substantially underestimate the extent and impact of invasions.
Triheterometallic Lanthanide Complexes Prepared from Kinetically Inert Lanthanide Building Blocks
Authors: Sørensen Thomas Just , Tropiano Manuel , Kenwright Alan M. , Faulkner Stephen 
Published: April 2017

AbstractInvited for the cover of this issue is the group of ThomasàJust Sørensen from the University of Copenhagen, Denmark, in collaboration with the group of Stephen Faulkner from Oxford University, UK. The cover image shows the antenna effect, which enhances lanthanide‐centered emission.
Preparation of Indium Tin Oxide Nanoparticle‐modified 3‐Aminopropyltrimethoxysilane‐functionalized Indium Tin Oxide Electrode for Electrochemical Sulfide Detection
Authors: Aziz Md. Abdul , Mahfoz Wael , Nasiruzzaman Shaikh M. , Zahir Md. Hasan , Al‐Betar Abdul‐Rahman , Oyama Munetaka , Theleritis Demetrios , Yamani Zain Hassan 
Published: April 2017

AbstractA sulfide sensor based on an indium tin oxide nanoparticle (ITONP)‐modified ITO electrode was developed. To prepare ITONP‐modified ITO, various methods were tested. Drop‐drying of ITONPs (aq.) on aminopropyltrimethoxysilane‐functionalized ITO (APTMS/ITO) was found to be the best method on the basis of voltammetric analysis of the sulfide ion. ITONP‐modified APTMS/ITO (ITONP/APTMS/ITO) yielded much better electrocatalytic properties toward sulfide electro‐οxidation than did bare or APTMS/ITO electrodes. The ITONPs and ITONP‐modified ITO were also characterized using transmission electron microscopy and field emission scanning electron microscopy, respectively. Optimization of the type of inert electrolyte and pH yielded an ITONP/APTMS/ITO detector whose amperometrically and chronocoulοmetrically determined limits of detection for sulfide were 3.0 μM and 0.90 μM, respectively. ITONP/APTMS/ITO electrodes displayed reproducible performance, were highly stable, and were not susceptible to interference by common contaminants. Thus, the developed electrode can be considered as a promising tool for sensing sulfide.
Evidence of significant forward rupture directivity aggravated by soil response in an Mw6 earthquake and the effects on monuments
Authors: Garini E. , Gazetas G. , Anastasopoulos I. 
Published: April 2017

SummaryWhile strong directivity effects have been mostly recognized in Mw > 6.5 earthquakes, the paper investigates the case of a strong such effect in a relatively small‐magnitude event on 3 February 2014 in the island of Cephalonia, Greece. The second of two events (both of Mw ≈ 6) produced a pernicious accelerogram in the region's main town, Lixouri. The paper provides evidence from geology, interferometry, and seismology to convince that the motion was the result of constructive interference in front of the direction of rupture of the obliquely‐strike‐slip fault. The nature of the record is explored to demonstrate that its frequency content, its high velocity pulse, and its strong fault‐normal (FN) favorable polarity are associated with directivity. Moreover, the broad spectral acceleration peak (of 1.7 g) of the FN motion, centered at a period (T ≈ 1.4 s) which almost coincides with the period of the velocity pulse, is shown to have also been affected by soil amplification, in quantitative agreement with Bray et al. (2009). Such a directivity‐and‐soil‐affected motion explains much of the profound damage to monuments, slopes, and harbor quaywalls. In particular, toppling (as well as excessive rotation and sliding) of nearly‐all the tombstones in Lixouri cemetery are shown to correlate well with characteristics of the FN component of motion. By contrast, the excellent performance of the building stock — despite the destructive shaking that prevailed — is persuasively attributed to conservatively‐robust construction practices of the past and the high base shear coefficient of the strict latest (2000) seismic code. Copyright © 2017 John Wiley & Sons, Ltd.
Effectiveness of incorporating cetuximab into docetaxel/cisplatin/fluorouracil induction chemotherapy and chemoradiotherapy for inoperable squamous cell carcinoma of the oral cavity: A phase II study
Authors: Chang Peter Mu‐Hsin , Lu Hsueh‐Ju , Wang Ling‐Wei , Tai Shyh‐Kuan , Chen Ming‐Huang , Chu Pen‐Yuan , Yang Muh‐Hwa 
Published: April 2017

AbstractBackgroundInoperable oral cavity squamous cell carcinoma (SCC) is a highly invasive disease associated with the extensive destruction of locoregional tissues and a dismal prognosis. Management strategies for these patients are limited.MethodsThis study was a single arm, prospective, open‐label phase II trial. A regimen consisting of cetuximab‐docetaxel, cisplatin, and fluorouracil (C‐TPF) followed by bio‐chemoradiotherapy (bio‐CRT) with cisplatin and cetuximab was administered to patients who responded to induction chemotherapy. The objective response rate to C‐TPF was the primary endpoint.ResultsForty‐three patients were enrolled in this study. The objective response rate of C‐TPF was 88.4%; 88.9% (32/36) of the responders completed the full bio‐CRT course, and the objective response rate of bio‐CRT was 64.7%. The most common grade 3/4 adverse events for induction chemotherapy were leucopenia (32.6%) and febrile neutropenia (14.0%). The 1‐year progression‐free survival (PFS) and overall survival (OS) rates were 43% and 68%, respectively.ConclusionC‐TPF is an effective and tolerable induction chemotherapy regimen for inoperable oral cavity SCC.
Matched cohort study of external cephalic version in women with previous cesarean delivery
Authors: Keepanasseril Anish , Anand Keerthana , Soundara Raghavan Subrahmanian 
Published: April 2017

AbstractObjectiveTo evaluate the efficacy and safety of external cephalic version (ECV) among women with previous cesarean delivery.MethodsA retrospective study was conducted using data for women with previous cesarean delivery and breech presentation who underwent ECV at or after 36 weeks of pregnancy during 2011–2016. For every case, two multiparous women without previous cesarean delivery who underwent ECV and were matched for age and pregnancy duration were included. Characteristics and outcomes were compared between groups.ResultsECV was successful for 32 (84.2%) of 38 women with previous cesarean delivery and 62 (81.6%) in the control group (P=0.728). Multivariate regression analysis confirmed that previous cesarean was not associated with ECV success (odds ratio 1.89, 95% confidence interval 0.19–18.47; P=0.244). Successful vaginal delivery after successful ECV was reported for 19 (59.4%) women in the previous cesarean delivery group and 52 (83.9%) in the control group (P<0.001). No ECV‐associated complications occurred in women with previous cesarean delivery.ConclusionTo avoid a repeat cesarean delivery, ECV can be offered to women with breech presentation and previous cesarean delivery who are otherwise eligible for a trial of labor.
Bactericidal effect of photocatalytically‐active nanostructured TiO2 surfaces on biofilms of the early oral colonizer, Streptococcus oralis
Authors: Westas Emma , Hayashi Mariko , Cecchinato Francesca , Wennerberg Ann , Andersson Martin , Jimbo Ryo , Davies Julia R 
Published: April 2017

AbstractThis study evaluated the photocatalytic bactericidal effect of nanostructured anatase‐rich titanium dioxide (TiO2) on microbial biofilms. Commercially pure titanium discs were spin‐coated with photocatalytic TiO2 nanoparticles (P25). Uncoated discs were used as control (CTRL). Half of the CTRL and half of the P25‐coated surfaces were coated with purified saliva (SAL) to give four different groups (CTRL, CTRL + SAL, P25 and P25 + SAL). Streptococcus oralis were allowed to form biofilms on the discs for 18 h and non‐adherent cells were rinsed off. Bacterial viability was assessed at time 0 with Live/Dead BacLight staining and epifluorescence microscopy. The remaining discs were divided into a non‐UV group and UVA‐irradiated (+UV) group (irradiation time, 6 or 24 h). Thereafter, viability was assessed as above. Viability at time 0 was high and no dead cells were seen on any of the surfaces, even after 24 h, in the absence of UVA. However, after 24 h of exposure, the proportion of viable cells was reduced by 40% on the P25 discs compared to 0 and 6 h, and this effect was enhanced with a salivary pellicle. Members of mixed species biofilms differ in their susceptibility to the bactericidal effect of the surfaces tested and further investigations are needed to optimize the conditions. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2321–2328, 2017.
Pharmacokinetics of Macitentan in Patients With Pulmonary Arterial Hypertension and Comparison With Healthy Subjects
Authors: Issac Milena , Dingemanse Jasper , Sidharta Patricia N. 
Published: April 2017

AbstractMacitentan is a worldwide approved dual endothelin receptor antagonist that has demonstrated efficacy in the treatment of pulmonary arterial hypertension (PAH) in a phase 3 clinical trial, SERAPHIN, at a dose of 10 mg once daily. During this trial, trough plasma concentrations (Ctrough) of macitentan and its active metabolite, ACT‐132577, were obtained at steady state in 242 patients, indicating that mean Ctrough of both analytes was about 2‐fold higher in PAH patients than in healthy subjects. To further investigate the pharmacokinetics (PK) of macitentan and its active metabolite, ACT‐132577, a 24‐hour PK profile was recorded at steady state in 20 PAH patients in the open‐label extension of SERAPHIN. A cross‐study comparison showed that although Ctrough in PAH patients is higher when compared with a historical reference group of healthy subjects, with geometric mean ratios of 1.45 and 1.36 for macitentan and ACT‐132577, respectively, this does not translate to a significant difference in exposure expressed as maximum plasma concentration (Cmax) or area under the plasma concentration–time curve over a dosing interval (AUCτ). Geometric mean ratios for Cmax and AUCτ were 1.08 and 1.22, respectively, for macitentan and 1.24 and 1.31, respectively, for ACT‐132577. Therefore, overall exposure at steady state to macitentan and ACT‐132577 in PAH patients is considered similar to that in healthy subjects.
Sonographic diagnosis of acute mastoiditis and subsequent retroauricular abscess in a pediatric cochlear implant recipient: A case report
Authors: Sakaida Hiroshi , Usui Satoko , Matsuda Yasunori , Masuda Sawako , Takeuchi Kazuhiko 
Published: April 2017

ABSTRACTWhen acute mastoiditis occurs in cochlear implant recipients, it can progress to subsequent retroauricular abscess due to the absence of the external mastoid cortex resulting from mastoidectomy performed for cochlear implantation. The management goal is to control infection while preserving the implanted device. A 2‐year‐old boy with cochlear implants developed acute mastoiditis and a subsequent retroauricular abscess. The patient underwent a surgical intervention based on the diagnosis made utilizing gray‐scale and power Doppler sonography. This case illustrates the diagnostic usefulness of sonography in this rare situation. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 45:515–519, 2017
The impact of hyperglycemia on adhesion between endothelial and cancer cells revealed by single‐cell force spectroscopy
Authors: Malek‐Zietek Katarzyna E. , Targosz‐Korecka Marta , Szymonski Marek 
Published: April 2017

AbstractThe impact of hyperglycemia on adhesion between lung carcinoma cells (A549) and pulmonary human aorta endothelial cells (PHAEC) was studied using the single‐cell force spectroscopy. Cancer cells were immobilized on a tipless Atomic Force Microscopy (AFM) cantilever and a single layer of endothelial cells was prepared on a glass slide. The measured force‐distance curves provided information about the detachment force and about the frequency of specific ligand‐receptor rupture events. Measurements were performed for different times of short term (up to 2 h) and prolonged hyperglycemia (3 h ‐ 24 h). Single‐cell force results were correlated with the expression of cell adhesion molecules (intercellular adhesion molecule, P‐selectin) and with the length and density of the PHAECs glycocalyx layer, which were measured by AFM nanoindentation. For short‐term hyperglycemia, we observed a statistically significant increase of the adhesion parameters that was accompanied by an increase of the glycocalyx length and expression of P‐selectin. Removal of hyaluronic acid from PHAECs glycocalyx significantly decreased the adhesion parameters, which indicates that hyaluronic acid has a strong impact on adhesion in A549/PHAEC system in short term of hyperglycemia. For prolonged hyperglycemia, the most significant increase of adhesion parameters was observed for 24 hours and this phenomenon correlated with the expression of adhesion molecules and a decrease of the glycocalyx length. Taking together, presented data indicate that both mechanical and structural properties of the endothelial glycocalyx strongly modulate the adhesion in the A549/PHAEC system.
Tired of innovations? Learned helplessness and fatigue in the context of continuous streams of innovation implementation
Authors: Chung Goo Hyeok , Choi Jin Nam , Du Jing 
Published: April 2017

SummaryThe business environment faced by contemporary organizations is highly uncertain and constantly changing. Thus, organizations have adopted and implemented a continuous stream of innovations to achieve sustainable growth and survival. Considering the demand for additional resources to implement innovations, the present study explores organizational conditions that may lead to innovation‐targeted burnout and fatigue among employees, which impede their active participation in a subsequent innovation. To this end, we propose a theoretical framework that elucidates the effects of previous innovations on the subsequent implementation behavior of employees. We identify two dimensions of the cognitive appraisal of previous innovations (i.e., intensity and failure) that shape employees' beliefs regarding innovations, such as innovation‐targeted helplessness, which ultimately results in innovation fatigue. Data collected from 84 managers and 397 employees of Chinese and Korean organizations prove the significant role of employee perceptions of previous innovations in shaping the innovation‐targeted helplessness and fatigue of employees, which ultimately affect employee behavior toward a subsequent innovation. The present conceptual and empirical analyses suggest that given continuous streams of innovation implementation, managers should carefully consider employee's perceptions of previous innovations (i.e., intensity and failure) for successful implementation of a subsequent innovation. Copyright © 2017 John Wiley & Sons, Ltd.
SERS detection of hepatitis B virus DNA in a temperature‐responsive sandwich‐hybridization assay
Authors: Zengin Adem , Tamer Ugur , Caykara Tuncer 
Published: April 2017

In this study, we report the design of a DNA sensor for the detection of a DNA sequence representative of the hepatitis B virus (HBV) based on a sandwich assay and surface‐enhanced Raman scattering (SERS) measurement. The temperature‐responsive hybrid silicon substrate was first prepared via immobilization of capture DNA strand at the surface of gold nanoparticles on the hybrid silicon substrate. A sandwich strategy was then applied for the detection of target DNA that brings a reporter DNA labeled with indocyanine green to the proximity of the surface, leading to high SERS signals. The temperature‐responsive hybrid silicon substrate‐based SERS platform can detect the remarkably lowest HBV DNA concentrations at ~0.44 fm at 25 °C and ~0.14 fm at 37 °C, respectively, which are comparable with the lowest HBV DNA concentration ever via other techniques. We expect this highly sensitive and robust hybrid silicon substrate‐based SERS platform can be extended to detect other biomolecules and chemical species such as viruses, proteins, and small molecules without any labeling. Copyright © 2017 John Wiley & Sons, Ltd.