bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development
Authors: Acevedo-Calado Maria , James Eddie A. , Morran Michael P. , Pietropaolo Susan L. , Ouyang Qin , Arribas-Layton David , Songini Marco , Liguori Marco , Casu Anna , Auchus Richard J. , Huang Shuai , Yu Liping , Michels Aaron , Gianani Roberto , Pietropaolo Massimo 
Published: February 2017

OBJECTIVE
The characterization of diverse subtypes of diabetes is a dynamic field of clinical research and an active area of discussion. The objective of this study was to identify new antigenic determinants in the neuroendocrine autoantigen IA-2 (ICA512) and assess whether circulating autoantibodies directed to new IA-2 epitopes identify autoimmune diabetes in young and adult populations with diabetes.

RESEARCH DESIGN AND METHODS
Clinically diagnosed patients with type 2 diabetes (n = 258; diabetes duration: 0.01–31 years) were evaluated using a new biomarker detecting autoantibodies directed to the extracellular domain of the neuroendocrine autoantigen IA-2 (IA-2ec). The proportion of IA-2ec autoantibodies was also evaluated in newly diagnosed patients with type 1 diabetes (n = 150; diabetes duration: 0.04–0.49 years). In addition, IA-2 (intracellular domain), GAD65, and zinc transporter 8 autoantibodies were assayed.

RESULTS
IA-2ec autoantibodies were detected in patients with type 1 diabetes and, surprisingly, in 5% of patients with type 2 diabetes without serologic responses to other IA-2 antigenic epitopes or other islet autoantigens. We also assessed the ability of IA-2ec–derived peptides to elicit CD4+ T-cell responses by stimulating peripheral blood mononuclear cells from patients with type 1 diabetes (n = 18) and HLA-matched healthy subjects (n = 13) with peptides and staining with the peptide/DQ8-specific tetramers, observing disease-associated responses to previously unreported epitopes within IA-2ec.

CONCLUSIONS
We developed a new antibody biomarker identifying novel antigenic determinants within the N terminus of IA-2. IA-2ec autoantibodies can be detected in patients with type 1 diabetes and in a subgroup of adult autoimmune patients with type 2 diabetes phenotype negative for conventional islet autoantibody testing. These observations suggest that islet autoimmunity may be more common in clinically diagnosed type 2 diabetes than previously observed.
Proinflammatory Cytokines Predict the Incidence and Progression of Distal Sensorimotor Polyneuropathy: KORA F4/FF4 Study
Authors: Herder Christian , Kannenberg Julia M. , Huth Cornelia , Carstensen-Kirberg Maren , Rathmann Wolfgang , Koenig Wolfgang , Heier Margit , Püttgen Sonja , Thorand Barbara , Peters Annette , Roden Michael , Meisinger Christa , Ziegler Dan 
Published: February 2017

OBJECTIVE
Experimental and epidemiological studies have implicated inflammatory processes in the pathogenesis of distal sensorimotor polyneuropathy (DSPN), but prospective studies are lacking. We hypothesized that biomarkers of inflammation predict the development and progression of DSPN in a population-based cohort.

RESEARCH DESIGN AND METHODS
This study was based on participants aged 62–81 years from the Cooperative Health Research in the Region of Augsburg (KORA) F4/FF4 cohort, with a mean follow-up of 6.5 years. The predictive value of systemic levels of eight biomarkers of inflammation was assessed for incident DSPN in 133 incident case subjects and 397 individuals without incident DSPN, and for DSPN progression in 57 patients with prevalent DSPN at both time points.

RESULTS
Higher hs-CRP, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1 receptor antagonist (IL-1RA), and soluble intercellular adhesion molecule (sICAM-1) and lower adiponectin levels were associated with incident DSPN in age- and sex-adjusted analysis; IL-18 and omentin were not. IL-6 (odds ratio 1.31 [95% CI 1.00–1.71]) and TNF-α (odds ratio 1.31 [95% CI 1.03–1.67]) remained associated with incident DSPN after adjusting for known DSPN risk factors. The addition of both cytokines to a clinical risk model improved model fit and reclassification. sICAM-1 and IL-1RA were positively associated with progression of DSPN.

CONCLUSIONS
Systemic subclinical and vascular inflammation predicted both the onset and progression of DSPN over 6.5 years in an older general population. Thus modulation of inflammatory processes may be relevant to prevent and/or treat diabetic neuropathy.
Pod Maturity in the Shelling Process
Authors: Carter E.T. , Rowland D.L. , Tillman B.L. , Erickson J.E. , Grey T.L. , Gillett-Kaufman J.L. , Clark M.W. 
Published: February 2017

ABSTRACT
Determining an optimum harvest maturity for indeterminate crops such as peanut is critical because it directly affects yield and grade. Historically, the assumption has been that growers will harvest at optimum maturity due to the positive impact on these two characteristics. However, the increased acreage under management by a single farmer may cause growers to harvest prior to optimum maturity. The impact of peanut maturity on seed quality may not be fully understood by producers, where immature seed may have reduced emergence and vigor. Research was conducted to quantify the maturity of seed peanuts received by the Florida Foundation Seed Producers, Inc. (FFSP) at various stages of the shelling process: samples received from the field; after the in-shell samples were cleaned; after in-shell pre-sizing into two size classes; and after separation of in-shell samples at the gravity deck. Samples collected at each stage were pressure-washed to remove the exocarp and then separated into yellow and brown/black color classes based on the maturity board. Pods within each color class were counted, dried, weighed, and graded. Maturity at each sheller stage was assessed for three peanut cultivars. For the field stage, across all cultivars, 56% of pods were in the mature, or brown/black color class. This was well below the level of 70-80% in the brown/black class purported to be the maturity level that optimizes yield and grade. Cleaning had a minor impact on maturity percentages (average percent mature was 64% across all cultivars after passing through the mechanical cleaning process); however, in the pre-shelling sizing process where pods are sorted into “lead” and “small” baskets representing large and small pods, respectively, the maturity percentage was improved to 75% in the large pods and declined to 45% in the small pods. These results indicate that: 1) maturity levels of cultivars harvested in the field may not be optimal; and 2) that improvements could be made in maturity percentages by modifying the shelling process to separate the larger pods which are more likely to be mature than the smaller pods. These results also suggest that seed peanut lots are unlikely to be composed entirely of mature pods, that large numbers of immature pods could make it through the shelling process and that immature seed are planted by farmers. This could explain some cases of suboptimal plant stands in peanut.
Demeter “Nods” to Aphrodite? Narrative Interactions between the “Homeric” Hymn to Aphrodite and the Hymn to Demeter
Authors: Maravela Anastasia 
Published: February 2017

Les signes de Déméter à Aphrodite ? Interactions narratives entre l’Hymne
homérique à Déméter et l’Hymne à Aphrodite.
Cet article reprend la question de la relation entre deux hymnes dits homériques, l’Hymne à Aphrodite et l’Hymne à Déméter, sur un plan narratif et thématique. Le propos insiste sur les motifs narratifs et les éléments identifiables dans les deux poèmes : rôle de Zeus, déesses déguisées, enlèvements et disparitions, épiphanies divines, immortalité refusée et compensation, etc. Les correspondances sont nombreuses et peuvent montrer des schémas et des mécanismes d’interaction. Cela suggère que l’Hymne à Déméter peut avoir emprunté et adapté des éléments narratifs de l’Hymne à Aphrodite. Le substrat commun est le souci des deux textes de la tension entre finitude et immortalité. Même si aucun des éléments narratifs communs ne peut résoudre seul la question de l’interdépendance, les arguments discutés en démontrent la possibilité.
Le pronom anaphorique ὅγε chez Homère
Authors: Bertrand Nicolas 
Published: February 2017

The Anaphoric Pronoun ὅγε in Homer An exhaustive analysis of the all the tokens of the demonstrative pronoun ὅ.
followed by the particle γε in Homer shows that we must recognize a true pronoun
ὅγε. Its function is to create an exclusive anaphora, i. e. to refer back to a referent evoked in the preceding discourse, excluding explicitly all other possible candidates. Due to this process of exclusive anaphora, ὅγε marks either identity or referential continuity, which explains its role in discourse. The semantic mechanism ὅγε generates makes it apt to express Ratified Topics, which explains its positional properties in the utterance (it is generally postpositive).
The Interpretation of Iliad, I, 1-2: Language, Meter, Style, and Myth
Authors: Schein Seth L. 
Published: February 2017

Interprétation du chant I de l’Iliade : langue, mètre, style et mythe.
L’article propose une lecture détaillée des deux premiers vers de l’Iliade, qui fait appel aux approches savantes développées par Hermann Fränkel, Milman Parry et Joannes Kakridis sur la poésie homérique. Elle montre en détail comment Homère utilise les normes linguistiques, métriques, stylistiques et le mythe d’une manière distinctive au début de l’épopée, remplissant et décevant à la fois les attentes de ses publics et de ses lecteurs et attirant l’attention sur le thème central du poème, qui est l’héroïsme mortel et à Achille, le héros mortel par excellence.
Il Palladion e la statua di Atena a Troia: riflessioni su due temi iconografici e sulla loro fusione
Authors: Castiglioni Maria Paola 
Published: February 2017

The Palladion and the Statue of Athena at Troy : Considerations about two Iconographical Themes and their Fusion.
This article suggests some considerations about the process of assimilation between the Palladion, the statue-talisman that, according to the Epic Cycle tradition, protected Troy from ruin as long as it was located within the citadel, and the cult statue of Athena in the goddess’ temple in Troy. This study analyzes in particular the literary tradition and the iconography of two mythical episodes : the theft of the Palladion (or the Palladia) by Odysseus and Diomedes, and Cassandra’s rape by Ajax under the eyes of Athena’s simulacrum.
Marques et signes dans le mythe de Philomèle
Authors: Delattre Charles 
Published: February 2017

Marks and Signs in the Myth of Philomela.
The name of Philomela in ancient Greece is famously used in two interconnected sets of references, one centered on poetic lament and the other on Philomela’s metamorphosis. In this last case, where weaving plays a central role, mythographic sources have often been overlooked. However we contend that their ambiguities and silences, when it comes to reporting the episode around which the story revolves, are fundamental : what is on the tapestry that Philomela sends to her sister Procne and that reveals to her Philomela’s rape ? An analysis of graphè and hyphasma will show how the history of Philomela, in the mythographic corpus, can be understood as a myth of representation.
Variations sur l’immortalité. Tithon et la cigale chez Sappho (fragment 58) et dans la tradition homérique
Authors: Pataki Elvira 
Published: February 2017

Le message de l’exemplum du fragment 58 de Sappho est un sujet vivement disputé. La poétesse âgée se met en parallèle avec Tithon, vieillard par excellence de la mythologie, sans indiquer quelle variante du mythe est évoquée. Tithon ne représenterait que la misère de la vieillesse ou bien le poème ferait-il allusion à sa métamorphose en cigale, symbole de l’immortalité et du chant ? L’examen d’une part se concentre sur les variantes du mythe de Tithon chez Homère, dans l’Hymne
homérique à Aphrodite et sur sa réception hellénistique (Callimaque), d’autre part il revisite le symbole des cigales dans la poésie archaïque pour ajouter quelques éléments concernant l’éventuel rôle métapoétique du motif chez Sappho.
Structure et fonctionnement des écosystèmes du Haut-Rhône français. 42. Etude du cycle biologique d'Heptagenia sulphurea (Müller 1776) (Ephemeroptera: Heptageniidae) dans le Rhône à Lyon
Authors: Kallab-Wakim Fadia 
Published: February 2017

Le cycle vital d'Heptagenia sulphurea (Miiller 1776) (Ephemeroptera : Heptageniidae) a été étudié dans le Rhône, parallèlement à l'examen physicochimique du milieu, de janvier 1975 à septembre 1977.
Deux techniques ont été utilisées pour conduire cette étude : captures mensuelles de larves au moyen de substrats artificiels et élevages de larves au laboratoire, dans les mêmes conditions de température que dans le milieu naturel.
Cinq classes de taille sont décrites, en fonction de l'état de développement des fourreaux alaires.
Dans le Rhône, à Lyon, H. sulphurea semble être une espèce univoltine, possédant une vie larvaire d'au moins 9 mois. La période où les adultes sont présents s'étend sur 6 mois.
Sexuality Workshop For Adolescents: Participative Strategy For Collective Knowledge Construction
Authors: Silva Marques Ferreira Maria de Lourdes , Coelho Graziele De Paula , Meneguin Silmara , Regiani Conde Carla , Moerbeck Cardoso Mazzetto Fernanda , Corrêa de Paula Tamires 
Published: February 2017

Background: This is a quali- quantitative research and was conducted in a basic health unit aiming to investigate female adolescents’ knowledge, practices and attitudes concerning sexuality.
Methodology: The action-research methodology was used to develop workshop activities because it is a participative methodology. The workshop was performed in two modules with the participation of 29 female adolescents, and data were collected by questionnaires addressing two groups of adolescents who had or had not begun sexual activity.
Results: The representations about sexuality were related to sexual relationships and showed erroneous information concerning sexually transmitted infections, which makes the adolescents vulnerable. Many of them reported not to know anything about infections or contraceptive methods, to know about contraceptive pills and condoms and to have doubts about condom use, and when experiencing sexuality, gender manifestation was present in the adolescents’ descriptions.
Conclusion: Strict gender roles and a patriarchal and a chauvinistic social structure determine adolescents’ behaviors that make them believe in two opposing worlds, the masculine and the feminine worlds. With this regard, identities are constructed in multiple institutions that produce and reproduce differences. Among such institutions, schools, families and the media are noteworthy, since, despite social and individual resistance movements, they impose behavioral models according to prevailing social practices and to the objectives of the consumer and producer market. It is important to reflect about the inclusion of sexual diversity in order to act in this reality by understanding sexuality in the perspective of human rights.
Key words: Sexuality, Adolescent, Health.
Blue Supergiant X-Ray Binaries in the Nearby Dwarf Galaxy IC 10
Authors: Laycock Silas G. T. , Christodoulou Dimitris M. , Williams Benjamin F. , Binder Breanna , Prestwich Andrea 
Published: February 2017

Abstract
In young starburst galaxies, the X-ray population is expected to be dominated by the relics of the most massive and short-lived stars, black hole and neutron-star high-mass X-ray binaries (XRBs). In the closest such galaxy, IC 10, we have made a multi-wavelength census of these objects. Employing a novel statistical correlation technique, we have matched our list of 110 X-ray point sources, derived from a decade of Chandra observations, against published photometric data. We report an 8σ correlation between the celestial coordinates of the two catalogs, with 42 X-ray sources having an optical counterpart. Applying an optical color–magnitude selection to isolate blue supergiant (SG) stars in IC 10, we find 16 matches. Both cases show a statistically significant overabundance versus the expectation value for chance alignments. The blue objects also exhibit systematically higher

ratios than other stars in the same magnitude range. Blue SG-XRBs include a major class of progenitors of double-degenerate binaries, hence their numbers are an important factor in modeling the rate of gravitational-wave sources. We suggest that the anomalous features of the IC 10 stellar population are explained if the age of the IC 10 starburst is close to the time of the peak of interaction for massive binaries.
Observational Evidence of Magnetic Reconnection for Brightenings and Transition Region Arcades in IRIS Observations
Authors: Zhao Jie , Schmieder Brigitte , Li Hui , Pariat Etienne , Zhu Xiaoshuai , Feng Li , Grubecka Michalina 
Published: February 2017

Abstract
By using a new method of forced-field extrapolation, we study the emerging flux region AR11850 observed by the Interface Region Imaging Spectrograph and Solar Dynamical Observatory. Our results suggest that the bright points (BPs) in this emerging region exhibit responses in lines formed from the upper photosphere to the transition region, which have relatively similar morphologies. They have an oscillation of several minutes according to the Atmospheric Imaging Assembly data at 1600 and 1700 Å. The ratio between the BP intensities measured in 1600 and 1700 Å filtergrams reveals that these BPs are heated differently. Our analysis of the Helioseismic and Magnetic Imager vector magnetic field and the corresponding topology in AR11850 indicates that the BPs are located at the polarity inversion line and most of them are related to magnetic reconnection or cancelation. The heating of the BPs might be different due to different magnetic topology. We find that the heating due to the magnetic cancelation would be stronger than the case of bald patch reconnection. The plasma density rather than the magnetic field strength could play a dominant role in this process. Based on physical conditions in the lower atmosphere, our forced-field extrapolation shows consistent results between the bright arcades visible in slit-jaw image 1400 Å and the extrapolated field lines that pass through the bald patches. It provides reliable observational evidence for testing the mechanism of magnetic reconnection for the BPs and arcades in the emerging flux region, as proposed in simulation studies.
The Effect of Protoplanetary Disk Cooling Times on the Formation of Gas Giant Planets by Gravitational Instability
Authors: Boss Alan P. 
Published: February 2017

Abstract
Observational evidence exists for the formation of gas giant planets on wide orbits around young stars by disk gravitational instability, but the roles of disk instability and core accretion for forming gas giants on shorter period orbits are less clear. The controversy extends to population synthesis models of exoplanet demographics and to hydrodynamical models of the fragmentation process. The latter refers largely to the handling of radiative transfer in three-dimensional (3D) hydrodynamical models, which controls heating and cooling processes in gravitationally unstable disks, and hence dense clump formation. A suite of models using the β cooling approximation is presented here. The initial disks have masses of 0.091 M
⊙ and extend from 4 to 20 au around a 1 M
⊙ protostar. The initial minimum Toomre Q

i
values range from 1.3 to 2.7, while β ranges from 1 to 100. We show that the choice of Q

i
is equal in importance to the β value assumed: high Q

i
disks can be stable for small β, when the initial disk temperature is taken as a lower bound, while low Q

i
disks can fragment for high β. These results imply that the evolution of disks toward low Q

i
must be taken into account in assessing disk fragmentation possibilities, at least in the inner disk, i.e., inside about 20 au. The models suggest that if low Q

i
disks can form, there should be an as yet largely undetected population of gas giants orbiting G dwarfs between about 6 au and 16 au.
Searching for Dwarf Hα Emission-line Galaxies within Voids. III. First Spectra
Authors: Moody J. Ward , Draper Christian , McNeil Stephen , Joner Michael D. 
Published: February 2017

Abstract
The presence or absence of dwarf galaxies with

in low-density voids is determined by the nature of dark matter halos. To better understand what this nature is, we are conducting an imaging survey through redshifted Hα filters to look for emission-line dwarf galaxies in the centers of two nearby galaxy voids called FN2 and FN8. Either finding such dwarfs or establishing that they are not present is a significant result. As an important step in establishing the robustness of the search technique, we have observed six candidates from the survey of FN8 with the Gillett Gemini telescope and GMOS spectrometer. All of these candidates had emission, although none was Hα. The emission in two objects was the [O iii]λ4959, 5007 doublet plus Hβ, and the emission in the remaining four was the [O ii]λ3727 doublet, all from objects beyond the void. While no objects were within the void, these spectra show that the survey is capable of finding emission-line dwarfs in the void centers that are as faint as

, should they be present. These spectra also show that redshifts estimated from our filtered images are accurate to several hundred km s−1 if the line is identified correctly, encouraging further work in finding ways to conduct redshift surveys through imaging alone.
Two New Calcium-rich Gap Transients in Group and Cluster Environments
Authors: Lunnan R. , Kasliwal M. M. , Cao Y. , Hangard L. , Yaron O. , Parrent J. T. , McCully C. , Gal-Yam A. , Mulchaey J. S. , Ben-Ami S. , Filippenko A. V. , Fremling C. , Fruchter A. S. , Howell D. A. , Koda J. , Kupfer T. , Kulkarni S. R. , Laher R. , Masci F. , Nugent P. E. , Ofek E. O. , Yagi M. , Yan Lin 
Published: February 2017

Abstract
We present the Palomar Transient Factory discoveries and the photometric and spectroscopic observations of PTF11kmb and PTF12bho. We show that both transients have properties consistent with the class of calcium-rich gap transients, specifically lower peak luminosities and rapid evolution compared to ordinary supernovae, and a nebular spectrum dominated by [Ca ii] emission. A striking feature of both transients is their host environments: PTF12bho is an intracluster transient in the Coma Cluster, while PTF11kmb is located in a loose galaxy group, at a physical offset ∼150 kpc from the most likely host galaxy. Deep Subaru imaging of PTF12bho rules out an underlying host system to a limit of

, while Hubble Space Telescope imaging of PTF11kmb reveals a marginal counterpart that, if real, could be either a background galaxy or a globular cluster. We show that the offset distribution of Ca-rich gap transients is significantly more extreme than that seen for SNe Ia or even short-hard gamma-ray bursts (sGRBs). Thus, if the offsets are caused by a kick, they require higher kick velocities and/or longer merger times than sGRBs. We also show that almost all Ca-rich transients found to date are in group and cluster environments with elliptical host galaxies, indicating a very old progenitor population; the remote locations could partially be explained by these environments having the largest fraction of stars in the intragroup/intracluster light following galaxy–galaxy interactions.