bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of meaning‐centered interventions on existential distress and mental health outcomes in cancer survivors and their family caregivers: A systematic review and meta‐analysis of randomized controlled trials
Authors: Wang Ziqi , Xu Dongsheng , Yu Shuanghan , Liu Yantong , Han Yujie , Zhao Wei , Zhang Wei 
Published: October 2024

AbstractBackgroundCancer is a global public health concern that causes psychosocial and spiritual challenges in those who suffer from it and their family caregivers. Meaning‐centered interventions have a positive impact on improving anxiety and depression in patients with advanced cancer. However, the impact of meaning‐centered interventions on existential distress of patients with cancer and family caregivers' mental health is still unclear.AimsTo examine the efficacy of meaning‐centered interventions in alleviating existential distress, enhancing quality of life, and fostering a sense of meaning among cancer survivors and their family caregivers.MethodsThis systematic review and meta‐analysis were conducted according to the Preferred Reporting Item for Systematic Reviews and Meta‐analysis 2020 statement. A comprehensive search was conducted from inception until September 2023 across nine databases: PubMed, Embase, Web of Science, PsycINFO, The Cochrane Library, CINAHL, Scopus, WANFANG, and CNKI. Heterogeneity testing and meta‐analyses were conducted using Review Manger 5.3. We calculated standard mean deviations and 95% confidence intervals and presented forest plots for assessing intervention effects. Two reviewers independently evaluated the risk of bias of all included articles. STATA 17.0 was used for publication bias analysis.ResultsThe review included 25 studies with 2399 participants, and 22 were included in the meta‐analysis. Meaning‐centered interventions enhanced quality of life, alleviated existential distress, and reduced depressive symptoms and cancer‐related fatigue. They did not affect spiritual well‐being. The subgroup analysis showed that the individual form and long‐term intervention (≥3 months) enhanced the quality of life in cancer survivors. Meaning‐centered interventions reduce depression in advanced cancer survivors more than in mixed‐stage cancer survivors. Meaning‐centered interventions significantly enhanced benefit finding for family caregivers.Linking Evidence to ActionMeaning‐centered interventions may improve mental health for patients with cancer and their family caregivers. Future research must include diverse cultural perspectives to understand the impact of meaning‐centered interventions on various groups.
Effect of prolonged sitting on dynamic cerebral autoregulation in the anterior and posterior cerebral circulations
Authors: Saito Shotaro , Tsukamoto Hayato , Karaki Marino , Kunimatsu Narumi , Ogoh Shigehiko 
Published: October 2024

AbstractIndividuals who experience prolonged sitting daily are reported to be at risk of developing cerebrovascular disease, which is associated, in part, with attenuation in cerebral blood flow regulation. However, the effect of prolonged sitting on dynamic cerebral autoregulation (dCA), a crucial mechanism of cerebral blood flow regulation, remains unclear. Additionally, cerebrovascular disease occurs heterogeneously within cerebral arteries. The purpose of the present study was to examine the hypothesis that prolonged sitting attenuates dCA in the cerebral circulation heterogeneously. Twelve young, healthy participants were instructed to maintain a seated position for 4 h without moving their lower limbs. Mean arterial pressure and mean blood velocities of the middle cerebral artery (MCA Vm) and the posterior cerebral artery (PCA Vm) were measured continuously throughout the experiment. The dCA was assessed using transfer function analysis (TFA) with mean arterial pressure and either MCA Vm or PCA Vm. In the MCA, very low‐frequency TFA‐normalized gain decreased significantly during 4 h of prolonged sitting (P = 0.029), indicating an improvement rather than attenuation in dCA, despite a significant reduction in MCA Vm after 4 h of continuous sitting (P = 0.039). In the PCA, PCA Vm remained stable throughout the 4 h sitting period (P = 0.923), and all TFA parameters remained unchanged throughout the 4 h of sitting. Contrary to our hypothesis, these results suggest that the dCA in both the MCA and the PCA was well stabilized in healthy young individuals during acute prolonged sitting.
A Variable Orifice Damping Mechanism for a Reciprocating Piston-Cylinder Pump
Authors: Melling Jonathan , Dumnov Daniil , Nørgaard Christian , Johnston Nigel , Sell Nathan 
Published: October 2024

Abstract
Digital Displacement pumps (DDP) are variable displacement radial piston pumps. Each cylinder comprises of a solenoid operated low pressure check valve and a passive high pressure check valve. Variable displacement is achieved by altering the number of active cylinders, and the proportion of the stroke for which the cylinder is pressurised. DDP has been demonstrated to be quieter and possess a significantly less tonal sound quality than traditional variable displacement axial piston swashplate pumps[1]. However, as the industry continues to trend towards battery electric driven excavators, the existing masking noise produced by conventional diesel combustion engines will cease to exist. Consequently, the hydraulic system will be the most significant noise source on the machine, driving the need to further refine pump Noise, Vibration & Harshness (NVH) performance. Passive check valves produce a characteristic in-cylinder pressure overshoot as upstream pressure has to be sufficient to overcome downstream pressure forces, plus resistive spring and damping forces responsible for holding the valve in place. Within a DDP, the transient nature of a pressure overshoot is very effective at exciting several different high frequency responses of the pump, most noticeably fluid-borne noise, and consequently radiated noise. This paper presents a method for incorporating a damping mechanism within a piston which reduces pressure overshoot, allowing an investigation into the relationship between pressure overshoot, fluid-borne noise and radiated noise. Modelling methodology is presented demonstrating a reduction in pressurisation rate and overshoot during the pumping cycle. Several key design variables are shown to give a large range in tuning scope. Initial test results are presented, demonstrating good model correlation and improvement in NVH performance.
Extension of the Flow Calculation in ISO 6358 by Real Gas Behavior to Enhance Accuracy of Hydrogen Simulations
Authors: Reinertz Olivier , Schmitz Katharina 
Published: October 2024

Abstract
The flow resistance of pneumatic valves and restrictors is usually characterized and modeled by means of ISO 6358. Under ideal gas assumption, which is valid for conventional pneumatics, the proposed equations fulfill the task with sufficient accuracy. The development of hydrogen storage systems and filling stations requires modelling of hydrogen networks at pressures of up to 100 MPa. Under these conditions, ideal gas assumptions are no longer valid, and the flow behavior is only roughly approximated by means of the existing equations. Contrary to this, the real gas effect on the critical flow through measurement nozzles is intensively discussed in ISO 9300. It includes tabulated flow factors for the supercritical flow regime for a small number of selected gases but excludes the effect on subcritical flow.
To circumvent these shortcomings, this paper presents at first an easy-to-implement numerical approach to model the real gas flow through ideal nozzles using tabulated thermodynamic values. Thereof, the set of equations in ISO 6358 is enhanced, to include real gas effects by means of tabulated factors to ease implementation and reduce calculation efforts by omitting iterative solving. Both approaches cover the entire flow regime and allow unrestricted application for all gaseous media and operating points. After model validation, the effects on the flow rate are discussed, emphasizing the need for such models.
Energy Efficient Pneumatic Drive for Membrane Pumps
Authors: Schmid Matthias , Reinertz Olivier , Schmitz Katharina 
Published: October 2024

Abstract
Membrane pumps are frequently employed for liquid pumping under various conditions. Advantageous of the design is an absence of the need for lubrication and moving seals, making the pumps very robust. This makes them particularly suitable for use in the food processing and pharmaceutical industries and allows use in applications with abrasive liquids. Although the pneumatic drive allows operation in potentially explosive environments, for example, it also requires a considerable amount of energy. The present work aims to reduce the compressed air requirement by increasing the efficiency.
Firstly, in this paper, losses in current systems are highlighted. The significance of actually unused expansion energy is explained and an approach for its utilization is introduced. In this context, the modification of the system with an upstream throttle is also described. This is particularly important with regard to the new type of mechanism for efficiency optimization, which is presented next. It consists of a spring with negative spring stiffness, which is used to utilize the expansion energy. This suppresses the expansion during the first motion interval, temporarily stores and releases its energy during the stroke. This supports the displacement and reduces the pressure requirement in the drive chamber over the stroke. By means of a lumped parameter simulation, the usual operating conditions with downstream throttling and pressure reducer are examined. The results are compared to the variant with upstream throttling and the new concept with a bistable mechanism. The results validate the huge potential for compressed air savings up to 85 % at an average of 60 %.
An Improved Thermal Modelling Approach for Industrial Hydraulic System Applications, Prioritizing Computational Time Reduction and Thermal Condition Analysis
Authors: Al-Issa Ahmad , Schulze Tobias , Weber Jürgen 
Published: October 2024

Abstract
Efficiently modelling and analyzing the thermal behavior of industrial hydraulic systems poses a significant challenge due to their intricate nature and the multitude of components. In addition, existing thermal models rely on cross-coupled parameters, such as temperature, pressure, flow rate, etc. and numerous measurement sensors. This results in prolonged modelling times that by far exceed the actual operational duration of the modelled hydraulic system by a factor of 2 to 6.5 times for a time-step 2 × 10−4 s or less. To address this issue and align with industrial requirements, an improved lumped parameter model is presented based on average transient temperature Tavg. This simplifies enthalpy calculations and accelerates simulation time.
Influence of Dissolved Air Content on Cavitation in Internal Gear Pumps
Authors: Böttig Paul , Müller Lutz , Osterland Sven , Weber Jürgen 
Published: October 2024

Abstract
Internal gear pumps are one of the most popular fixed-displacement hydraulic pumps due to their high reliability, low pressure pulsation, and comparatively low cost.
Following previous research on stationary valve models, using high-speed imaging technology and simulation to better understand the interactions of dissolved air, cavitation, and cavitation erosion, an internal gear pump was examined.
The goal of the experiment was to determine the individual influences of gas and vapour cavitation on suction-side cavitation, which determines a hydrostatic pump’s top speed. The identification of the individual mechanisms leads to considerable improvements in the modelling of cavitation effects in numerical simulations of hydrostatic pumps.
To realize this, a commercially available Eckerle internal gear pump was modified to be see-through with no major changes to its flow geometry. The pump’s top speed was increased to 5000rpm. A variety of sensors and high-speed imaging were used to determine pump performance and cavitation intensity. The examined parameters of the experiment were dissolved air content, suction pressure, and rotational frequency.
The recorded measurements were used to create a characteristic map of the pump’s volumetric efficiency under constant load pressure for varying suctions pressures and dissolved air contents. The hardware-triggered images were taken synchronized with the pump’s rotation and captured the gears in 260 equally spaced frames per revolution.
The images of the individual gear positions were processed to determine the cavitation intensity at each operating point.
Agent-Based Control of Fluid Systems Using Microcontrollers: Development and Integration
Authors: Lefemmine Oscar L. , Meck Tobias C. , Logan Kevin T. , Pelz Peter F. 
Published: October 2024

Abstract
Fluid systems play a crucial role with respect to economic and societal interests, and their increasing complexity demands intelligent control concepts for efficient operation. Conventional control approaches have limitations, making distributed control, based on so-called agents, a promising solution. In distributed control an agent is allocated to a component of the fluid system. Utilizing sensors and actuators the agent perceives and manipulates its surrounding. Furthermore, the exchange of information between agents is crucial to this control method. This paper presents the physical implementation of two agent-based controllers into a test rig for distributed water supply systems, focusing on the hardware components needed. The considered fluid system comprises several active and passive components like pumps and valves, respectively. As a first step, a pump and a valve are equipped with an agent. A minimal example of distributed control is presented in which the volumetric flow rate through the valve is measured by a sensor and shared with the pump agent, which then controls the pump’s speed accordingly. To enable this, the agent must have suitable rotational hardware interfaces to connect sensors and actuators and facilitate communication with other agents. At the core of each agent lies an ESP32 microcontroller, which operates as a discrete PID controller and enables web-based communication for data exchange.
Diagnostic performance of PET-CT and technical efficacy of ultrasound-guided core needle biopsy of small and intermediate size malignant supraclavicular lymph nodes
Authors: Choi Woo Hee , Bae Jiwon , Shin Jae Ho 
Published: October 2024

Aim: We aimed (1) to determine optimal PET-CT SUV and ultrasound (US) features associated for malignant smallintermediate size supraclavicular lymph nodes (SCN) and (2) to evaluate technical efficacy of core needle biopsy (CNB). Materials and methods: Between 2020 and 2023, CNB of SCN with short-axis less than 15 mm were included. PET-CT was evaluated for optimal SUV cut-off value. Multivariate logistic regression was performed for US features. Technical efficacy of CNB (success rate) was calculated, and US features were compared between satisfactory CNB specimen and unsatisfactory CNB specimen.Results: Eighty-four SCN per 80 patients (age 64.0±17.2 years, 45.2% female) were included. The optimal SUV cut-off value was 1.1 with diagnostic accuracy of 89.8%. US features associated with malignancy were anteroposterior dimension ≥9 mm and absence of hilum. The overall CNB success rate was 94%, and unsatisfactory specimen demonstrated shorter transverse diameter (12 mm vs 5 mm, p<0.001), and non-parallel orientation (20.3% vs. 100%, p<0.001).Conclusion: CNB should be considered for small-intermediate size SCN with SUV exceeding 1.1, anteroposterior dimension ≥9 mm, and absence of hilum. SCN with shorter transverse diameter and non-parallel orientation may result in unsatisfactory CNB specimen.
Continental crustal growth in the post-collisional setting: Insights from the Late Triassic high-Mg andesites in the eastern Central Asian Orogenic Belt
Authors: Zhang Liying , Huang Feng , Xu Jifeng , Liu Xijun , Yang Xuli , Zhang Zhao , Zhang Man , Zeng Yunchuan , Zattin Massimiliano 
Published: October 2024

Abstract
The Central Asian Orogenic Belt represents the most important site of crustal growth in the Phanerozoic. However, the intricate evolution of multi-ocean regimes has given rise to uncertainties surrounding the processes of Mesozoic tectonic evolution and the dynamics of crustal growth. In this study, we conducted detailed geochronological and geochemical analyses of andesites collected from the eastern Central Asian Orogenic Belt. Zircon U-Pb dating results show that these andesites formed during the Late Triassic (ca. 235 Ma), and the Ti-in-zircon thermometer reveals high magma temperatures (&gt;1100 °C) during their genesis. The elevated Mg# values at moderate SiO2 content of these Late Triassic andesites indicate an affinity with high-Mg andesites (HMAs). Notably, the andesites exhibit relatively low K2O/Na2O ratios, high Sr/Y ratios, significant depletion of Nb and Ta, and trace element patterns resembling typical HMAs from the western Aleutian Islands. These characteristics suggest that they likely originated from the partial melting of subducted eclogite. Furthermore, the HMAs display relatively high zircon εHf(t) values and depleted whole-rock Sr-Nd isotopic compositions, which is indicative of a depleted mantle source. Therefore, we propose that these andesites were generated through the interaction of the subducting slab–derived melts and overlying mantle wedge. Considering that the final closure of the Paleo-Asian Ocean took place before the Late Triassic, these andesites probably erupted in a post-collisional setting. The formation of these HMAs could be best explained by the upwelling asthenosphere triggered by the break-off of the oceanic slab, which also contributed to continental crustal growth in Northeast China.
Targeting CDCP1 boost CD8+ T cells-mediated cytotoxicity in cervical cancer via the JAK/STAT signaling pathway
Authors: Huang Hua , Pan Yuwen , Mai Qiuwen , Zhang Chunyu , Du Qiqiao , Liao Yuandong , Qin Shuhang , Chen Yili , Huang Jiaming , Li Jie , Liu Tianyu , Zou Qiaojian , Zhou Yijia , Yuan Li , Wang Wei , Liang Yanchun , Pan Chao Yun , Liu Junxiu , Yao Shuzhong 
Published: October 2024

BackgroundCervical cancer remains a global health challenge. The identification of new immunotherapeutic targets may provide a promising platform for advancing cervical cancer treatment.ObjectiveThis study aims to investigate the role of CUB domain-containing protein 1 (CDCP1) in cervical cancer progression and evaluate its potential as a therapeutic target.MethodsWe performed comprehensive analyses using patient cohorts and preclinical models to examine the association between CDCP1 expression and cervical cancer prognosis. Then in immunodeficient and immunocompetent mouse models, we further investigated the impact of CDCP1 on the tumor immune microenvironment, focusing on its effects on tumor-infiltrating T cells, including cytotoxic T lymphocytes (CTLs) and regulatory T cells (Tregs). Mechanistic studies were performed to elucidate the pathways involved in CDCP1-mediated immune modulation, in particular its interaction with the T cell receptor CD6 and the activation of the JAK-STAT signaling pathway.ResultsOur results show that CDCP1 overexpression is associated with poor prognosis and T cell infliction in cervical cancer. Specifically, it affects the activity of CTLs and Tregs. Mechanistically, CDCP1 binds to CD6 and inhibits the JAK-STAT pathway of T cells. The study further demonstrates that targeting CDCP1 with the inhibitor 8-prenylnaringenin (8PN) effectively suppresses tumor growth in vivo and enhances antitumor immunity.ConclusionsCDCP1 plays a critical role in cervical cancer progression by modulating the tumor immune microenvironment. Targeting CDCP1 offers a promising therapeutic strategy to improve the outcome of patients with cervical cancer.
SPI1+CD68+macrophages as a biomarker for gastric cancer metastasis: a rationale for combined antiangiogenic and immunotherapy strategies
Authors: Deng Guofei , Wang Pengliang , Su Rishun , Sun Xuezeng , Wu Zizhen , Huang Zhangsen , Gu Liang , Yu Hong , Zhao Zhenzhen , He Yulong , Huo Mingyu , Zhang Changhua , Yin Songcheng 
Published: October 2024

BackgroundTumor-associated macrophages (TAMs) have been demonstrated to be associated with tumor progression. However, the different subpopulations of TAMs and their roles in gastric cancer (GC) remain poorly understood. This study aims to assess the effects of Spi-1 proto-oncogene (SPI1)+CD68+TAMs in GC.MethodsThe distribution of SPI1+CD68+TAMs in GC tissue was estimated by immunohistochemistry, immunofluorescence, and flow cytometry. Single-cell transcriptome analysis and multiplex fluorescence immunohistochemistry were applied to explore the role of SPI1+CD68+TAMs in an immune contexture. SPI1 overexpression or knockdown cells were constructed to evaluate its role in macrophage polarization and angiogenesis in vitro and in vivo. Chromatin immunoprecipitation was used to verify the mechanism of SPI1 transcriptional function. The effect of combined antiangiogenic and immunotherapy was further validated using mouse peritoneal metastasis models.ResultsSingle-cell transcriptome analysis and immunohistochemistry demonstrated that SPI1 was expressed in macrophages, with a higher enrichment in metastatic lesions than in primary tumors. Higher SPI1+CD68+TAMs infiltration was associated with poor overall survival. Mechanically, SPI1 promoted the M2-type macrophage polarization. SPI1 could bind to the promoter of vascular endothelial growth factor A and facilitate angiogenesis. Moreover, the level of SPI1+CD68+TAMs infiltration was closely related to the efficacy of immunotherapy, especially when combined with antiangiogenic therapy.ConclusionsThe present study showed that SPI1+CD68+TAMs are a promising biomarker for predicting prognosis, antiangiogenic drug sensitivity, and combination target of immunotherapy in patients with GC.