bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peripheral Artery Occlusive Disease Among Patients With Chronic Myeloid Leukemia Receiving Tyrosine Kinase Inhibitors: A Cross-Sectional Case-Control Study
Authors: Rattanathammethee Thanawat , Tantiworawit Adisak , Rattarittamrong Ekarat , Chai-Adisaksopha Chatree , Hantrakool Sasinee , Phrommintikul Arintaya , Wongcharoen Wanwarang , Gunaparn Siriluck , Norasetthada Lalita 
Published: December 2017

Background: There were some reports of peripheral artery occlusive disease (PAOD) associated with nilotinib usage in chronic myeloid leukemia (CML). These complications in other tyrosine kinase inhibitors are revealed as unknown. Materials and methods: We determined the prevalence of PAOD in patients with CML as compared with matched-control population by cross-sectional case-control study. Peripheral artery occlusive disease was screened by ankle-brachial index (ABI). Results: In total, 78 CML and 156 matched-control patients were included. The median age was 55 years. In all, 61 (78.2%) were on imatinib and 13 (16.7%) were on nilotinib, whereas 4 patients (5.2%) were on dasatinib. Prevalence of low ABI (<0.9) was 9.0%, and nilotinib users had the highest prevalence of low ABI of 30.7%. All cases with low ABI were not shown to be clinically overt of PAOD. There were well-balanced characteristics between cases of CML and matched control except in higher levels of hypercholesterolemia in the control. Interestingly, CML had more amounts of pathologic ABI than the control (odds ratio: 2.09, 95% confidence interval: 0.71-6.21), and diagnosis of diabetes found it to be independent of the risk of PAOD. Conclusions: Peripheral artery occlusive disease was higher among patients with CML than the control, especially in patients who had diabetes.
Phantom limb pain: a review of pharmacological management
Authors: Hall Neil , Eldabe Sam 
Published: December 2017

Introduction: Phantom limb pain (PLP) is a complex condition resulting in pain in the missing limb affecting 60–80% amputees. Increasing number of patients are undergoing amputations. Approximately 1 per every 1000 people in the United Kingdom is an amputee. Incidence of PLP can be as high as 80% following amputation. PLP can be severe and difficult to treat. A range of pharmacological interventions exist yet little is known about them in respect to PLP. This article will address the effectiveness of both single pharmacological, therapy as well as drug combination therapy. Methods: We reviewed all literature looking at the evidence for the efficacy of both single and combined pharmacological therapy in the management of phantom limb pain. Not all commonly prescribed analgesic agents have been studied in the use of PLP and in these cases, the evidence of their efficacy in neuropathic pain was reviewed Conclusion: It is difficult to draw definitive conclusions on the pharmacological management of PLP based on current available evidence. Most trials involved small cohorts and were not specific to the PLP. The trials which looked specifically at the PLP population gave conflicting results. Only the N-methyl-d-aspartate (NMDA) receptor antagonist class demonstrated consistent positive results. Most notably ketamine did produce a reduction in pressure pain thresholds and pain windup associated with PLP, although the numbers in these studies remain small. This benefit was not demonstrated across all NMDA receptor antagonists. Combination therapy has demonstrated effectiveness in previous studies for neuropathic pain but this has never been tested specifically against a PLP cohort. Therefore, combination treatment of agents with proven efficacy in PLP such as opioid and gabapentin deserves a closer examination in a controlled study against a placebo as well as single drug therapy
Arthroscopic Fragment Resection for Capitellar Osteochondritis Dissecans in Adolescent Athletes: 5- to 12-Year Follow-up
Authors: Ueda Yusuke , Sugaya Hiroyuki , Takahashi Norimasa , Matsuki Keisuke , Tokai Morihito , Onishi Kazutomo , Hoshika Shota , Hamada Hiroshige 
Published: December 2017

Background: Capitellar osteochondritis dissecans (OCD) in skeletally immature athletes has often been seen in baseball players and gymnasts. The choice of surgical procedure for unstable lesions in skeletally immature athletes remains controversial. Purpose: To investigate functional outcomes and radiographic changes in the midterm to long-term postoperative period after arthroscopic (AS) resection for small to large capitellar OCD lesions in skeletally immature athletes. Study Design: Case series; Level of evidence, 4. Methods: A total of 38 elbows in 38 patients (33 boys, 5 girls; mean age, 14 years [range, 13-15 years]) with skeletally immature elbows underwent AS resection for capitellar OCD. Patients were observed for at least 5 years (mean, 8 years [range, 5-12 years]). Elbows with a lesion width that did not exceed one-half of the radial head diameter were assigned to group 1 (n = 17 elbows), and larger lesions were assigned to group 2 (n = 21 elbows). Functional scores, patient satisfaction, range of motion (ROM), and osteoarthritis (OA) grades were evaluated between the groups. Results: All patients returned to sports activity. Functional scores at the final follow-up were not significantly different between the groups. Patient satisfaction scores were significantly higher in group 1 than in group 2. There was significant improvement in flexion ROM at the final follow-up compared with preoperative values in group 1 ( P = .017), and there was a significant between-group difference (group 1: 141°; group 2: 133°; P = .002). Extension ROM showed significant improvement in both groups (group 1: from –8° to 3°; group 2: from –17° to –1°; P < .001 for both). Group 1 tended to have better extension than group 2, but the difference was not significant. There were no elbows with severe OA in either group, but the OA grade progressed in 5 elbows (29%) in group 1 and 9 elbows (43%) in group 2, and this rate of OA progression was statistically significant between groups ( P = .005). Conclusion: Both functional outcomes and radiological findings after AS fragment resection were excellent in elbows with small lesions. Although overall outcomes were acceptable in elbows with larger lesions, flexion ROM and patient satisfaction scores were significantly inferior to those in elbows with smaller lesions.
Ascribed Meaning of Disease Control
Authors: Girling Laura M , Chard Sarah E , Eckert J Kevin 
Published: December 2017

Background: Contemporary treatment of type 2 diabetes mellitus (hereafter diabetes) heavily emphasizes “diabetes control,” largely defined by measurable blood glucose parameters. Little is known about how people living with the condition themselves define diabetes control within the lived experience of their disease. Methods: As part of a qualitative study investigating the subjective construction of diabetes, 83 in-depth interviews were conducted with African American and non-Hispanic white older adults. Using content analysis, 4237 pages of narrative data were analyzed to explore how informants conceptualized diabetes control. Findings: Four themes emerged from the data, describing varied understandings of diabetes control: (a) blood sugar regulation, (b) practicable treatment adherence, (c) bodily experience, and (d) degree of pharmaceutical need. Findings demonstrate that among persons with diabetes, the term diabetes control is multifaceted. Conclusion: While clinical guidelines have established target blood glucose parameters as the standard indicator of diabetes control, persons with diabetes conveyed varied and diverse meanings situated within personal experiences. To foster empathetic and collaborative care, health-care providers tending to this population may consider integrating the emergent themes into communicative and treatment approaches.
Draft genome of Paraburkholderia caballeronis TNe-841T, a free-living, nitrogen-fixing, tomato plant-associated bacterium
Authors: Rojas-Rojas Fernando Uriel , Tapia-García Erika Yanet , Maymon Maskit , Humm Ethan , Huntemann Marcel , Clum Alicia , Pillay Manoj , Palaniappan Krishnaveni , Varghese Neha , Mikhailova Natalia , Stamatis Dimitrios , Reddy T. B. K. , Markowitz Victor , Ivanova Natalia , Kyrpides Nikos , Woyke Tanja , Shapiro Nicole , Hirsch Ann M. , Estrada-de los Santos Paulina 
Published: December 2017

Abstract
Paraburkholderia
caballeronis is a plant-associated bacterium. Strain TNe-841T was isolated from the rhizosphere of tomato (Solanum lycopersicum L. var. lycopersicum) growing in Nepantla Mexico State. Initially this bacterium was found to effectively nodulate
Phaseolus vulgaris
L. However, from an analysis of the genome of strain TNe-841T and from repeat inoculation experiments, we found that this strain did not nodulate bean and also lacked nodulation genes, suggesting that the genes were lost. The genome consists of 7,115,141 bp with a G + C content of 67.01%. The sequence includes 6251 protein-coding genes and 87 RNA genes.
Reading Performance, Reading Gender: Early Encounters with Beaumont and Fletcher’s <i>The Scornful Lady</i> in Print
Authors: Smith Simon 
Published: December 2017

This essay investigates Francis Beaumont’s seventeenth-century afterlife through material evidence left by early readers. Taking his immensely popular collaboration with John Fletcher, The Scornful Lady, as a test case, it traces patterns of shared interest and attention in different readers’ engagements with the play in quarto. Considering commonplacing habits, readers’ marks, and preparations for performance from a printed text, the article emphasizes fluidity between page- and stage-based engagements with drama in the seventeenth century. It also argues for the perhaps surprising receptiveness of Beaumont and Fletcher’s drama to readers’ reflections on and interrogations of gendered expectations, particularly regarding public female decorum.
Assessment of Mobility in Older People Hospitalized for Medical Illness Using the de Morton Mobility Index and Cumulated Ambulation Score-Validity and Minimal Clinical Important Difference
Authors: Trøstrup Jeanette , Andersen Helle , Kam Charlotte Agger Meiner , Magnusson S. Peter , Beyer Nina 
Published: December 2017

Background and Purpose:Older adults acutely hospitalized for medical illness typically have comorbidity and disability, and in-hospital physical inactivity greatly increases the likelihood of developing new disability. Thus, assessment of the patients' mobility status is crucial for planning and carrying out targeted interventions that ensure mobilization during hospital admission. The aim of this study was to determine convergent validity, known group validity, floor and ceiling effects, and anchor-based minimal clinically important difference (MCID) of the more time-consuming de Morton Mobility Index (DEMMI) and the less time-consuming Cumulated Ambulation Score (CAS) in older adults acutely hospitalized for medical illness.Methods:In this multicenter cohort study, 235 older hospitalized adults, with a mean (standard deviation) age of 84.8 (7.1) years, were consecutively included. Assessments of mobility using the DEMMI (score range 0-100), the CAS (score range 0-6), and the Barthel Index (BI, score range 0-100) were performed by physical or occupational therapists at hospital admission and discharge. In addition, at discharge patients and therapists were independently asked to assess the patients' current mobility status compared with their mobility status at hospital admission using the Global Rating of Change scale.Results and Discussion:Complete data sets were obtained for 155 patients. Baseline characteristics of those with complete data sets did not differ from those with incomplete data sets, except for the number of secondary diagnoses, which was lower in the latter. Significant and moderate relationships existed both at admission and at discharge between scores in the DEMMI and the BI (rs= 0.68,P< .0001, andrs= 0.71,P< .0001), and between scores in the CAS and the BI (rs= 0.60,P< .0001, andrs= 0.57,P< .0001). Use of a gait aid and discharge to inpatient rehabilitation or nursing home were associated with significantly lower DEMMI and CAS scores. No floor or ceiling effects were present in the DEMMI, while a ceiling effect was present in the CAS. The MCID scores based on patients' assessments were 10.7 points for the DEMMI and 0.67 for the CAS.Conclusions:These data show that the DEMMI is valid and responsive to changes in mobility and can be considered to have the required properties for measuring mobility in older adults who are hospitalized in medical and geriatric wards. In contrast, the CAS appears to be appropriate to identify whether a patient is independently mobile or needs assistance, while the measure is less suitable for measuring improvements in mobility.
Efficacy and Safety of Once-Weekly Semaglutide Versus Exenatide ER in Subjects With Type 2 Diabetes (SUSTAIN 3): A 56-Week, Open-Label, Randomized Clinical Trial
Authors: Ahmann Andrew J. , Capehorn Matthew , Charpentier Guillaume , Dotta Francesco , Henkel Elena , Lingvay Ildiko , Holst Anders G. , Annett Miriam P. , Aroda Vanita R. 
Published: December 2017

OBJECTIVE
To compare the efficacy and safety of once-weekly semaglutide 1.0 mg s.c. with exenatide extended release (ER) 2.0 mg s.c. in subjects with type 2 diabetes.

RESEARCH DESIGN AND METHODS
In this phase 3a, open-label, parallel-group, randomized controlled trial, 813 subjects with type 2 diabetes taking oral antidiabetic drugs were randomized (1:1) to semaglutide 1.0 mg or exenatide ER 2.0 mg for 56 weeks. The primary end point was change from baseline in HbA1c at week 56.

RESULTS
Mean HbA1c (8.3% [67.7 mmol/mol] at baseline) was reduced by 1.5% (16.8 mmol/mol) with semaglutide and 0.9% (10.0 mmol/mol) with exenatide ER (estimated treatment difference vs. exenatide ER [ETD] –0.62% [95% CI –0.80, –0.44] [–6.78 mmol/mol (95% CI –8.70, –4.86)]; P &lt; 0.0001 for noninferiority and superiority). Mean body weight (95.8 kg at baseline) was reduced by 5.6 kg with semaglutide and 1.9 kg with exenatide ER (ETD –3.78 kg [95% CI –4.58, –2.98]; P &lt; 0.0001). Significantly more subjects treated with semaglutide (67%) achieved HbA1c &lt;7.0% (&lt;53 mmol/mol) versus those taking exenatide ER (40%). Both treatments had similar safety profiles, but gastrointestinal adverse events were more common in semaglutide-treated subjects (41.8%) than in exenatide ER–treated subjects (33.3%); injection-site reactions were more frequent with exenatide ER (22.0%) than with semaglutide (1.2%).

CONCLUSIONS
Semaglutide 1.0 mg was superior to exenatide ER 2.0 mg in improving glycemic control and reducing body weight after 56 weeks of treatment; the drugs had comparable safety profiles. These results indicate that semaglutide treatment is highly effective for subjects with type 2 diabetes who are inadequately controlled on oral antidiabetic drugs.
Five-Year Cost-effectiveness of the Multidisciplinary Risk Assessment and Management Programme–Diabetes Mellitus (RAMP-DM)
Authors: Jiao Fang Fang , Fung Colman Siu Cheung , Wan Eric Yuk Fai , Chan Anca Ka Chun , McGhee Sarah Morag , Kwok Ruby Lai Ping , Lam Cindy Lo Kuen 
Published: December 2017

OBJECTIVE
To estimate the cost-effectiveness of the multidisciplinary Risk Assessment and Management Programme–Diabetes Mellitus (RAMP-DM) in primary care patients with type 2 diabetes in comparison with usual primary care in a cohort with 5 years’ follow-up.

RESEARCH DESIGN AND METHODS
We conducted a prospective cohort study among 17,140 propensity score–matched participants in RAMP-DM and those under usual primary care. The effectiveness measures were cumulative incidences of complications and all-cause mortality over 5 years. In a bottom-up approach, we estimated the program costs of RAMP-DM and health service utilization from the public health service provider’s perspective. The RAMP-DM program costs included the setup costs, ongoing intervention costs, and central administrative costs. We calculated the incremental cost-effectiveness ratio by dividing the incremental costs by the incremental effectiveness of the RAMP-DM group compared with those of the usual-care group.

RESULTS
There were significantly lower cumulative incidences of individual on any complications (15.34% vs. 28.65%, P &lt; 0.001) and all-cause mortality (7.96% vs. 21.35%, P &lt; 0.001) in the RAMP-DM group compared with the usual-care group. The mean program cost of RAMP-DM was 157 U.S. dollars (range 66–209) per participant over 5 years. The costs of health service utilization among participants in RAMP-DM group was 7,451 USD less than that of the usual-care group, resulting in a net savings of 7,294 USD per individual.

CONCLUSIONS
RAMP-DM added to usual primary care was a cost-saving intervention in managing diabetes in patients over 5 years. These findings support the integration of RAMP-DM as part of routine primary care for all patients with diabetes.
Blood Flow
Authors: Figueroa C. Alberto , Taylor Charles A. , Marsden Alison L. 
Published: December 2017

AbstractComputational methods have been used to simulate hemodynamics for several decades now. However, the field has experienced a remarkable advancement in the past 20 years, due to concurrent breakthroughs in medical imaging and computer hardware and software. It is now possible to create sophisticated patient‐specific models of hemodynamics to study cardiovascular disease, test the performance of medical devices, perform noninvasive diagnostics, and even virtually plan complex surgeries. In this chapter, we provide an overview of classic, well‐established methods for blood flow modeling and a summary of novel computational tools. We then review several salient clinical applications in which computational modeling has had a prominent role in the past few years and end the chapter with the discussion of current challenges and future opportunities.
Ship Hydrodynamics
Authors: Oñate Eugenio , García‐Espinosa Julio , Idelsohn Sergio R. , Serván‐Camas Borja 
Published: December 2017

AbstractThis chapter presents an overview of some computational methods for the analysis of problems in ship hydrodynamics. Attention is focused on the description of stabilized finite element formulations derived via a finite increment calculus (FIC) procedure. Both arbitrary Lagrangian–Eulerian (ALE) and fully Lagrangian forms are presented. Details of the treatment of the free‐surface waves and the interaction between the ship structure and the sea water are given. Potential flow formulations for seakeeping analysis and calculation of the added resistance in waves are also described. Examples of application of the computational methods presented to a variety of ship hydrodynamics and related problems are given.
Prescribed Performance Fine Attitude Control for a Flexible Hypersonic Vehicle with Unknown Initial Errors
Authors: Zhao He‐Wei , Liang Yong , Yang Xiu‐Xia , Hu Yun‐An 
Published: December 2017

AbstractThis is a study of a fine attitude control system design for a flexible hypersonic vehicle with unknown initial errors. A prescribed performance control method, backstepping control method, and RBF neural network method are used to design the controllers. A newly defined error transformation function is used to solve the unknown initial error issue in prescribed performance control. Different from traditional a RBF neural network, the fully‐tuned dynamic RBF neural network has better approximation ability, and the weight vector, respective centers, and width of the Gaussian function of the neural network are regulated by adaptive laws designed in the controller. The stability of the system is proved and analyzed in this paper for a fully‐tuned dynamic neural network introduced to the control system. Furthermore, prescribed performance control can guarantee the tracking errors satisfy the specified conditions and the fine attitude control can be implemented through the prescribed performance method. Finally, the simulations demonstrate the effectiveness and corrective ability of the control strategy.
The Strong β−CF3 Shielding Effect in Hexafluoroisopropanol and 100 Other Organic Solvents Revisited with 17O NMR Spectroscopy
Authors: Bernhardt Annika , Kelm Harald , Patureau Frederic W. 
Published: December 2017

AbstractAn 17O NMR spectroscopy survey of more than 100 ubiquitous organic solvents and compounds, including some typical oxofluorinated solvents such as hexafluoroisopropanol, trifluoroethanol, trifluoroacetic acid, and others, is presented with D2O as a reference. A strong alternating α,β−CF3‐substituent chemical shift effect was thus observed. This alternating deshielding–shielding effect is suspected to have a role in the exceptional properties of these oxofluorinated solvents, notably in oxidative cross‐coupling reactions.
Preparation of new ferroelectric Li0.95Ta0.57Nb0.38Cu0.15O3 materials as photocatalysts in microbial fuel cells
Authors: Louki Sami , Touach Nour‐eddine , Benzaouak Abdellah , Salar‐García María José , Ortiz‐Martínez Víctor Manuel , Hernández‐Fernández Francisco José , de los Ríos Antonia Pérez , El Mahi Mohammed , Lotfi El Mostapha 
Published: December 2017

AbstractA microbial fuel cell (MFC) is a device for both the generation of bioelectricity and the treatment of wastewater. However, its performance is affected by several parameters, and more particularly the materials used as the active phase at the cathode. In order to develop new, more efficient cathodes, two new non‐stoichiometric ferroelectric cathode materials are studied in this work. These electrodes have been synthesized according to two heat treatment modes (slow cooling and rapid cooling) from non‐stoichiometric ferroelectric materials with the formula Li0.95Ta0.57Nb0.38Cu0.15O3. The synthesized phases were characterized by X‐ray diffraction (XRD), transmission electronic microscopy (TEM), particle size distribution (PSD), and differential scanning calorimetry (DSC). The main characteristics of these phases are the Curie temperatures, 1217 and 1197 °C, and the specific surfaces of 0.572 and 0.801 m2/g for the slow and rapid cooling phases, respectively. These materials were subsequently tested as photocathodes in a single chamber MFC in terms of the bioenergy production and wastewater treatment, by measuring the output power density and the rate of removal of COD in the presence of a light source. For the samples prepared by slow and rapid cooling, the values of maximum power density were 20.10 and 205.35 mW/m3, respectively. The COD removal rates were 74 and 80 %, respectively. Accordingly, the phase prepared by rapid cooling was shown to be more efficient in terms of power generation and wastewater treatment with a significant improvement in photocatalytic activity.
High‐Pressure Synthesis of Nanodiamonds from Adamantane: Myth or Reality?
Authors: Ekimov Evgeny A. , Kudryavtsev Oleg S. , Mordvinova Natalia E. , Lebedev Oleg I. , Vlasov Igor I. 
Published: December 2017

AbstractThe high‐pressure and high‐temperature technique is the most promising for mass production of ultra‐small diamond nanoparticles of perfect structure. In the present work, this technique was successfully used for the synthesis of nanodiamonds from their molecular analogue, adamantane. A minimum size of synthesized diamond crystals of about 3 nm was reached. It was found that the decisive condition for the stable production of nanodiamonds from adamantane under pressures below the limit value required for direct conversion of graphite into diamond is the minimization of the carbon sample loss during the synthesis. The possibility of doping such diamonds with optically active impurities is demonstrated by the synthesis of submicron diamonds, containing nitrogen‐related centers, from a mixture of adamantane and adamantane carbonitrile.