bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Ironbark program: Implementation and impact of a community‐based fall prevention pilot program for older Aboriginal and Torres Strait Islander people
Authors: Lukaszyk Caroline , Coombes Julieann , Sherrington Catherine , Tiedemann Anne , Keay Lisa , Mackean Tamara , Clemson Lindy , Cumming Robert , Broe Tony , Ivers Rebecca 
Published: December 2017

AbstractAimTo document the implementation and investigate within‐group impact of The Ironbark Program: a community‐based, Aboriginal‐specific fall prevention program, in New South Wales, Australia.MethodsThe Ironbark Program was trialled in six Aboriginal communities over a three‐ to six‐month period. A mixed methods approach was used for program evaluation: strength, balance and gait were assessed to measure participant physical function and BMI was monitored. Semi‐structured participant interviews investigated program suitability, relevance and impact.ResultsNinety‐eight Aboriginal people aged 40+ years registered for the pilot program, 77 (79%) of whom were present at all assessment time points. There were significant improvements in participant leg strength (average time to complete five repetition sit‐to‐stand: 14 seconds to 11 seconds), balance (timed single‐leg stance: 5.6 seconds to 7.8 seconds), gait (timed 4 m walk: 0.51 m/s to 0.94 m/s) and a significant decrease in BMI (32.0 to 31.6) was observed. Participants reported enjoying the program and stated they would recommend it to others.ConclusionThe evaluation of the Ironbark Program demonstrated acceptability, and showed significant improvements in physical function. If proven to be effective in a definitive trial, this program could be used widely to prevent falls in older Aboriginal people.ImplicationsKey features of the Ironbark Program were local Aboriginal management, culturally relevant resources, ongoing availability and enabling program use for people aged less than 65 years. These features should be retained on the program's upscale, and may be incorporated into other healthy ageing programs developed for the Aboriginal population.
The oral health behaviours and fluid consumption practices of young urban Aboriginal preschool children in south‐western Sydney, New South Wales, Australia
Authors: George Ajesh , Grace Rebekah , Elcombe Emma , Villarosa Amy R. , Mack Holly A. , Kemp Lynn , Ajwani Shilpi , Wright Darryl C. , Anderson Cheryl , Bucknall Natasha , Comino Elizabeth 
Published: December 2017

AbstractIssue addressedAustralian Aboriginal children have a higher risk of dental caries yet there is limited focus on oral health risk factors for urban Aboriginal preschool children. This study examined the oral health behaviours and fluid consumption practices of young children from an urban Aboriginal community in south‐western Sydney, Australia.MethodsIn total, 157 Aboriginal children who were recruited to the “Gudaga” longitudinal birth cohort participated in this study. A survey design was employed and parents responded to the oral health questions when their child was between 18 and 60 months.ResultsFew parents (20%) were concerned about their child's oral health across the time period. By 60 months, only 20% of children had seen a dentist while 80% were brushing their teeth at least once daily. High levels of bottle use were seen up to 30 months. Consumption of sugary drinks was also very high in the early years, although this was replaced by water by 36 months.ConclusionsWhile there are some encouraging findings, such as the rates of tooth brushing and increasing rates of water consumption, the findings do highlight the poor uptake of dental services and high levels of bottle usage among urban aboriginal children during their early years.So what?Targeted oral health promotional programs are needed in the urban Aboriginal community to better support parents understanding of good oral health practices in the early years and engagement with dental health services.
A profile of health, lifestyle and training habits of 4720 Australian recreational runners—The case for promoting running for health benefits
Authors: Kozlovskaia Maria , Vlahovich Nicole , Rathbone Evelyne , Manzanero Silvia , Keogh Justin , Hughes David C. 
Published: December 2017

AbstractIssue addressedThe aim of this study was to characterise lifestyle and training habits of a large cohort of Australian recreational runners. Understanding the health benefits of recreational running and differentiating between the habits of males and females may allow for the development of gender‐specific messaging for promoting recreational running as a form of physical activity.MethodsAn online questionnaire was used to collect data from 4720 Australian recreational runners. Data on physical, lifestyle and training characteristics of male and female subgroups were compared using chi‐square tests. Multiple logistic regression method was used to assess the effect of running experience on the reported clinically significant weight loss.ResultsThe study cohort was 54.1% female and 45.9% male. Smoking was uncommon among surveyed runners. The most typical weekly running distance in the cohort was 20‐40 km, usually distributed by 2‐5 running sessions. Significantly more males than females reported running over 40 km per week (29.9% vs 18.9%, P < .001) and running at least six sessions per week (11.5% vs 6.7%, P < .001). The majority (72.9%) of runners had normal BMI, and the cohort reported a lower overweight/obesity rate than the Australian population. The logistic regression model indicated that commencing running may lead to a clinically significant weight loss irrespectively of sex, participation in other sports and injury history.ConclusionRecreational running was associated with beneficial health outcomes. Commencement of running is associated with weight loss, and regular running supports healthy weight maintenance. Male and female runners had different running preferences which should be taken into account for physical activity promotion.So what?Captured health outcomes associated with running and described sex differences in training patterns may assist in development of physical activity promotion programmes involving recreational running, particularly targeting weight loss and healthy weight maintenance.
STRONG MILITARY FAMILIES INTERVENTION ENHANCES PARENTING REFLECTIVITY AND REPRESENTATIONS IN FAMILIES WITH YOUNG CHILDREN
Authors: Julian M.M. , Muzik M. , Kees M. , Valenstein M. , Rosenblum K. L. 
Published: December 2017

ABSTRACTMilitary families face many challenges due to deployment and parental separation, and this can be especially difficult for families with young children. The Strong Military Families (SMF) intervention is for military families with young children, and consists of two versions: the Multifamily Group, and a Home‐based psychoeducational written materials program. The Multifamily Group was designed to enhance positive parenting through both educational components and in vivo feedback and support during separations and reunions between parents and children (n = 78 parents). In the present study, we examine parenting reflectivity and mental representations in mothers versus fathers in military families, service members versus civilian spouses/parenting partners, and before versus after participation in the SMF Multifamily Group and Home‐based interventions. Parenting reflectivity and mental representations were coded from the Working Model of the Child Interview (WMCI; C.H. Zeanah & D. Benoit, 1995). Results suggest that neither parenting reflectivity nor WMCI typology differs between mothers and fathers in military families, or between service members and civilian parenting partners. Furthermore, there was substantial stability in parenting reflectivity and WMCI typology from baseline to posttest, but participation in the Multifamily Group, relative to Home‐based, was associated with improvements in both parenting reflectivity and WMCI ratings from baseline to postintervention.
Knockdown of pseudogene derived from lncRNA DUXAP10 inhibits cell proliferation, migration, invasion, and promotes apoptosis in pancreatic cancer
Authors: Lian Yifan , Xiao Chuanxing , Yan Changsheng , Chen Dajun , Huang Qingwen , Fan Yanyun , Li Zhaohua , Xu Hongzhi 
Published: December 2017

AbstractCurrent evidence suggests that pseudogene derived lncRNAs may be important players in human cancer progression. Our previous study showed that DUXAP10 could promote cell proliferation in colorectal cancer. However, the clinical significance and potential role of DUXAP10 in human pancreatic cancer (PC) has not been uncovered. In this study, we found that DUXAP10 was overexpressed in PC tissues compared with normal tissues. DUXAP10 expression was significantly higher in patients with an advanced TNM stage and positive lymph node metastasis. Bioinformatic analysis showed that cell cycle progression was increased in patients with high DUXAP10 expression. In vitro and in vivo assays of DUXAP10 alterations revealed a complex integrated phenotype affecting cell growth, apoptosis, migration, and invasion. Mechanistic studies revealed that DUXAP10 has a crucial role in G2/M arrest. We further showed that DUXAP10 regulated PC cell proliferation through interact with RNA‐binding protein EZH2 and LSD1. Overall, our findings indicates that DUXAP10 is an oncogenic lncRNA that promotes PC proliferation and metastasis.
Associations between friendship characteristics and HIV and HSV‐2 status amongst young South African women in HPTN‐068
Authors: Fearon Elizabeth , Wiggins Richard D , Pettifor Audrey E , MacPhail Catherine , Kahn Kathleen , Selin Amanda , Gómez‐Olivé F Xavier , Delany‐Moretlwe Sinéad , Piwowar‐Manning Estelle , Laeyendecker Oliver , Hargreaves James R 
Published: December 2017

AbstractIntroductionPrevalence of HIV among young women in South Africa remains extremely high. Adolescent peer groups have been found to be an important influence on a range of health behaviours. The characteristics of young women's friendships might influence their sexual health and HIV risk via connections to sexual partners, norms around sexual initiation and condom use, or provision of social support. We investigated associations between young women's friendships and their Herpes Simplex Virus Type 2 (HSV‐2) and HIV infection status in rural South Africa.MethodsOur study is a cross‐sectional, egocentric network analysis. In 2011 to 2012, we tested 13‐ to 20‐year‐old young women for HIV and HSV‐2, and collected descriptions of five friendships for each. We generated summary measures describing friend socio‐demographic characteristics and the number of friends perceived to have had sex. We used logistic regression to analyse associations between friend characteristics and participant HIV and HSV‐2 infection, excluding likely perinatal HIV infections.ResultsThere were 2326 participants included in the study sample, among whom HIV and HSV‐2 prevalence were 3.3% and 4.6% respectively. Adjusted for participant and friend socio‐demographic characteristics, each additional friend at least one year older than the participant was associated with raised odds of HIV (odds ratio (OR) = 1.37, 95% CI 1.03 to 1.82) and HSV‐2 (adjusted OR=1.41, 95% CI 1.18 to 1.69). Each additional friend perceived to have ever had sex also raised the odds of HIV (OR = 1.29, 95% CI 1.03 to 1.63) and HSV‐2 (OR=1.18, 95% CI 1.03 to 1.35).DiscussionWe found good evidence that a greater number of older friends and friends perceived to have had sex were associated with increased risk for HSV‐2 and HIV infection among young women.ConclusionsThe characteristics of young women's friendships could contribute to their risk of HIV infection. The extent to which policies or programmes influence age‐mixing and young women's normative environments should be considered.
Electrochemical oxidation of phosphatidylethanolamines studied by mass spectrometry
Authors: Colombo Simone , Coliva Giulia , Kraj Agnieszka , Chervet Jean‐Pierre , Fedorova Maria , Domingues Pedro , Domingues M. Rosário 
Published: December 2017

AbstractPhosphatidylethanolamines (PEs) are widely present in cellular membranes and lipoproteins. Oxidation of PE fatty acyl chains generates several oxidized products, exerting a vast number of biological functions, not totally unveiled yet. In vitro biomimetic models have been used to identify oxidized PEs and to develop analytical strategies for their targeted detection in vivo. Most of the models are based on oxidation by reactive oxygen species (ROS), but the oxidative metabolism of PE also relies on controlled reactions catalyzed by enzymes as lipoxygenase, which can be mimicked by electrochemical (EC) oxidation. In this study, 3 PE standards (1‐palmitoyl‐2‐oleoyl‐sn‐glycero‐3‐phosphoethanolamine (POPE), 1‐palmitoyl‐2‐linoleoyl‐sn‐glycero‐3‐phosphoethanolamine (PLPE), and 1‐palmitoyl‐2‐arachidonoyl‐sn‐glycero‐3‐phosphoethanolamine (PAPE)) were oxidized by EC oxidation, using an EC flow‐through cell system as a biomimetic model of oxidative injury. The new oxidation products were identified by online EC electrospray ionization mass spectrometry (EC‐ESI‐MS and MS/MS). Long‐chain and short‐chain oxidation products were identified, bearing modifications in the sn‐2 acyl chains, whereas the oxidation pattern was dependent on the unsaturation level. Long‐chain oxidation products of PEs (keto, hydroxy, hydroperoxy, poly‐hydroperoxy derivatives) were identified, bearing up to 5, 7, and 10 oxygens for POPE, PLPE, and PAPE, respectively. Fourteen short‐chain oxidation products, 7 from PLPE, and 7 from PAPE, including aldehydes, γ‐hydroxy‐α,β‐aldehydes, and dicarboxylic acids were characterized. Some of these oxidized species were previously reported during the oxidative metabolism of PEs driven by ROS. The EC‐ESI‐MS platform was, therefore, able to mimic the oxidative metabolism of PEs mediated by ROS.
Analysis of rainfall trends over Indo‐Pakistan summer monsoon and related dynamics based on CMIP5 climate model simulations
Authors: Latif M. , Hannachi A. , Syed F. S. 
Published: December 2017

ABSTRACTUnderstanding the effects of climate change and global warming on the South Asian summer monsoon rainfall trend is critically important for millions of inhabitants of this region. This study investigates seasonal (June–September) rainfall trend over the Indo‐Pakistan subcontinent by using 36 climate model outputs from the World Climate Research Programme's Coupled Model Inter‐comparison Project Phase 5. The historical (1951–2005) and future (2006–2100) simulations under two representative concentration pathways (RCPs), RCP4.5 and RCP8.5, are analysed for this purpose. Model reproducibility is evaluated based on spatial correlation of seasonal rainfall and vertically integrated meridional moisture transport between simulated and observed fields. It is found that the majority of models shows reasonable skill in capturing the observed pattern of rainfall climatology and trend over the subcontinent. Our results showed that the models are more skilful in simulating seasonal mean moisture transport than trend over the Arabian Sea and Bay of Bengal. Of the 36 models analysed, only two models HadGEM2‐AO and CNRM‐CM5 closely approximate both the climatology and trend based on statistical performance metrics. Our results suggest that the strengthening of northwards moisture transport over the Arabian Sea and Bay of Bengal is a likely reason for the increasing rainfall trend over Indo‐Pakistan subcontinent in a warmer climate. The RCP8.5 indicates marked increase in both rainfall and moisture transport trends compared to RCP4.5 forcing scenario.
Adjuvant therapy is associated with improved survival after curative resection for hilar cholangiocarcinoma: A multi‐institution analysis from the U.S. extrahepatic biliary malignancy consortium
Authors: Krasnick Bradley A. , Jin Linda X. , Davidson Jesse T. , Sanford Dominic E. , Ethun Cecilia G. , Pawlik Timothy M. , Poultsides George A. , Tran Thuy , Idrees Kamran , Hawkins William G. , Chapman William C. , Doyle Maria B.M. , Weber Sharon M. , Strasberg Steven M. , Salem Ahmed , Martin Robert C.G. , Isom Chelsea A. , Scoggins Charles , Schmidt Carl R. , Shen Perry , Beal Eliza , Hatzaras Ioannis , Shenoy Rivfka , Maithel Shishir K. , Fields Ryan C. 
Published: December 2017

BackgroundCurative‐intent treatment for localized hilar cholangiocarcinoma (HC) requires surgical resection. However, the effect of adjuvant therapy (AT) on survival is unclear. We analyzed the impact of AT on overall (OS) and recurrence free survival (RFS) in patients undergoing curative resection.MethodsWe reviewed patients with resected HC between 2000 and 2015 from the ten institutions participating in the U.S. Extrahepatic Biliary Malignancy Consortium. We analyzed the impact of AT on RFS and OS. The probability of RFS and OS were calculated in the method of Kaplan and Meier and analyzed using multivariate Cox regression analysis.ResultsA total of 249 patients underwent curative resection for HC. Patients who received AT and those who did not had similar demographic and preoperative features. In a multivariate Cox regression analysis, AT conferred a significant protective effect on OS (HR 0.58, P = 0.013), and this was maintained in a propensity matched analysis (HR 0.66, P = 0.033). The protective effect of AT remained significant when node negative patients were excluded (HR 0.28, P = 0.001), while it disappeared (HR 0.76, P = 0.260) when node positive patients were excluded.ConclusionsAT should be strongly considered after curative‐intent resection for HC, particularly in patients with node positive disease.
Percutaneous hepatic perfusion with melphalan in uveal melanoma: A safe and effective treatment modality in an orphan disease
Authors: Karydis Ioannis , Gangi Alexandra , Wheater Matthew J. , Choi Junsung , Wilson Iain , Thomas Kerry , Pearce Neil , Takhar Arjun , Gupta Sanjay , Hardman Danielle , Sileno Sean , Stedman Brian , Zager Jonathan S. , Ottensmeier Christian 
Published: December 2017

BackgroundMetastatic uveal melanoma (UM) carries a poor prognosis; liver is the most frequent and often solitary site of recurrence. Available systemic treatments have not improved outcomes. Melphalan percutaneous hepatic perfusion (M‐PHP) allows selective intrahepatic delivery of high dose cytotoxic chemotherapy.MethodsRetrospective analysis of outcomes data of UM patients receiving M‐PHP at two institutions was performed. Tumor response and toxicity were evaluated using RECIST 1.1 and Common Terminology Criteria for Adverse Events (CTCAE) v4.03, respectively.ResultsA total of 51 patients received 134 M‐PHP procedures (median of 2 M‐PHPs). 25 (49%) achieved a partial (N = 22, 43.1%) or complete hepatic response (N = 3, 5.9%). In 17 (33.3%) additional patients, the disease stabilized for at least 3 months, for a hepatic disease control rate of 82.4%. After median follow‐up of 367 days, median overall progression free (PFS) and hepatic progression free survival (hPFS) was 8.1 and 9.1 months, respectively and median overall survival was 15.3 months. There were no treatment related fatalities. Non‐hematologic grade 3‐4 events were seen in 19 (37.5%) patients and were mainly coagulopathic (N = 8) and cardiovascular (N = 9).ConclusionsM‐PHP results in durable intrahepatic disease control and can form the basis for an integrated multimodality treatment approach in appropriately selected UM patients.
Determination of major aromatic constituents in vanilla using an on‐line supercritical fluid extraction coupled with supercritical fluid chromatography
Authors: Liang Yanshan , Liu Jiaqi , Zhong Qisheng , Shen Lingling , Yao Jinting , Huang Taohong , Zhou Ting 
Published: December 2017

AbstractAn on‐line supercritical fluid extraction coupled with supercritical fluid chromatography method was developed for the determination of four major aromatic constituents in vanilla. The parameters of supercritical fluid extraction were systematically investigated using single factor optimization experiments and response surface methodology by a Box–Behnken design. The modifier ratio, split ratio, and the extraction temperature and pressure were the major parameters which have significant effects on the extraction. While the static extraction time, dynamic extraction time, and recycle time had little influence on the compounds with low polarity. Under the optimized conditions, the relative extraction efficiencies of all the constituents reached 89.0–95.1%. The limits of quantification were in the range of 1.123–4.747 μg. The limits of detection were in the range of 0.3368–1.424 μg. The recoveries of the four analytes were in the range of 76.1–88.9%. The relative standard deviations of intra‐ and interday precision ranged from 4.2 to 7.6%. Compared with other off‐line methods, the present method obtained higher extraction yields for all four aromatic constituents. Finally, this method has been applied to the analysis of vanilla from different sources. On the basis of the results, the on‐line supercritical fluid extraction‐supercritical fluid chromatography method shows great promise in the analysis of aromatic constituents in natural products.
Manipulating the Surface Structure of Hybrid UV Curable Coatings through Photopolymerization‐Induced Phase Separation: Influence of Inorganic Portion and Photoinitiator Content
Authors: Mohammad Raei Nayini Mohsen , Bastani Saeed , Moradian Siamak , Croutxé‐Barghorn Céline , Allonas Xavier 
Published: December 2017

AbstractSurface topography and phase‐manipulated distribution of hybrid UV curable coatings is performed. Accordingly, phase separation is controlled by changing the inorganic/organic ratio and the photoinitiator content as these are the main thermodynamic and kinetic affecting factors, respectively. Chemical and mechanical evolution of the samples during photopolymerization is investigated by time‐resolved Fourier transform infrared spectroscopy and photorheometry, respectively. It is found that the samples that contain larger portion of inorganic oligomers are polymerized faster, but undergo gelation later; this provides them more time to undergo phase separation prior to gelation. Therefore, their surfaces become rougher and more heterogeneous, which is confirmed by atomic force microscopey. Furthermore, adding larger amounts of photoinitiator into the samples leads to them being photopolymerized faster and undergo gelation at lower conversion. So, they have less time and thermodynamic tendency to undergo phase separation prior to gelation; their surfaces thus become smoother and more homogeneous.