bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced peroxidase‐like activity of MnFe2O4 nanoparticles on halloysite nanotubes for uric acid detection
Authors: Shen Hengxia , Xiang Zhenbo , Dang Anfang 
Published: September 2024

AbstractNanozymes have significantly advanced sensing assays by replicating native enzyme functions. However, designing nanozymes with high catalytic activity and easy recyclability remains challenging. The study presented here has resulted in the development of a highly efficient and sensitive colorimetric system for the detection of uric acid, utilizing MnFe2O4@HNTs—a novel composite material consisting of MnFe2O4 loaded onto halloysite nanotubes. These nanocomposites exhibited outstanding peroxidase‐like activity and attractive magnetic properties. The catalytic efficiency of the MnFe2O4@HNTs in the oxidation of 3,3′,5,5′‐tetramethylbenzidine, in the presence of H2O2, was remarkable, leading to a distinct color change from colorless to blue. A linear relationship was observed between absorbance and UA concentration in the range of 1–20 μM, with a detection limit as low as 52 nM. Mechanistic investigations revealed that reactive oxygen species (ROS), specifically singlet oxygen (1O2), were generated through the decomposition of H2O2, which is responsible for the peroxidase‐like activity demonstrated by the MnFe2O4@HNTs. The method showed minimal interference from serum substances and high selectivity. Magnetic MnFe2O4 allowed easy separation and maintained over 95% activity after seven reuse cycles. The developed assay was successfully applied to the detection of uric acid in human serum, achieving recoveries greater than 98.60%. This research significantly advances the design of recyclable high‐performance nanozymes and establishes an effective colorimetric sensing platform for UA detection in clinical samples, potentially improving diagnostic tools for healthcare applications.
Dual‐Mode Optical Thermometers Based on the Thermal‐Stable Perovskite Nanocrystals Embedded in Robust Metal Halide Salts
Authors: Yang Dandan , Zhao Tianzhu , Peng Zixing , Xiao Xiudi , Dong Guoping 
Published: September 2024

AbstractPhotothermal sensing is crucial for the creation of smart integrated devices. All‐inorganic metal halide perovskites with the formula CsPbX3 (X═Cl, Br, I) have excellent photo‐physical performance, offering exciting opportunities for flexible electronics. Hence, a supersaturated precipitation strategy is proposed for the preparation of salt‐shelled metal halide solids. The well‐designed CsPbX3@MX (M═K, Cs) products exhibit bright narrow visible emissions and favorable thermal stability up to 195 °C. Co‐doping with Ni2+ and Mn2+ ions, the CsPbCl3@KCl products have realized dual‐mode thermometry. Utilizing the blue emission from the CsPbCl3 host and the red emission from the Mn2+ ion, a fluorescence intensity ratio technique is obtained to monitor the temperature of good stability and repeatability. Based on the regular fluorescence decay of Mn2+ ions with rising temperature, the lifetime of Mn2+ ions can also be used for temperature sensing. It is believed that such stable metal halides with dual‐mode thermometry will provide a new sight for optical thermometers and, more importantly, will unleash the possibility of a broad variety of applications in lightweight and integrated functional devices.
Terahertz Metasurfaces for Polarization Manipulation and Detection: Principles and Emerging Applications
Authors: Liu Yongliang , Xu Yifei , Yu Bo , Liu Wenwei , Zhang Zhengren , Cheng Hua , Chen Shuqi 
Published: September 2024

AbstractTerahertz frequencies locating between microwave and infrared regions can record and process optical information for next‐generation information technology such as 6G communication. Metasurfaces, as emerging planar optical components built with micro‐ or nanostructures, enable precise control, and manipulation of electromagnetic waves from near fields to far fields. These subwavelength artificial structures can be engineered to exhibit specific polarization responses, thus holding significant potential for applications in polarization detection. In the terahertz (THz) region, polarization information is crucial for identifying and analyzing the properties of materials in the terahertz. In this review, we focus on recent advances in terahertz metasurfaces for polarization manipulation and detection, including principles and emerging applications. New polarization detection methods such as polarization state conversion, polarization‐selective absorption, polarization‐selective focusing, and vector beam construction are discussed. Finally, it is concluded with a few perspectives on emerging trends and existing challenges in the fields of terahertz polarization manipulation and detection.
Viral metagenomic analysis reveals potential biological hazards in non‐human primates in a zoo
Authors: Liang Ruiying , Tang Xinming , Liang Lin , Ding Jiabo , Tian Ye , Qin Yixian , Zhao Sufen , Zhang Lixia , Pu Tianchun , Liu Xuefeng , Liu Jinpeng , Zhang Chenglin , Li Zibin , Jia Ting 
Published: September 2024

AbstractPathogens have been documented to be transmissible between humans and non‐human primates (NHPs), with NHPs demonstrating susceptibility to human viruses. Conducting surveillance for viruses in NHPs to identify potential zoonotic agents that may emerge or pose a high risk of spillover remains a critical strategy for preparing for and responding to future zoonotic events. This study employed viral metagenomic analysis on nine randomly selected NHPs from the Zoo in China to detect potential pathogens within captive environments. The analysis identified the presence of picornavirus Encephalomyocarditis virus (EMCV), poxvirus (BeAn 58,058 virus, BAV), and retroviruses (human endogenous retrovirus, HERV and baboon endogenous virus, BaEV). These viruses exhibited significant genetic homology to established viral strains, with EMCV demonstrating close relatedness to a strain previously detected in the United States, and BAV beling newly identified in NHPs. The study suggests that zoo rodents, particularly rats, serve as the primary reservoirs for the viruses, thereby posing a potential threat to public health. Therefore, this underscores the imperative to enhance rodent control measures within zoological institutions and provides strategic recommendations for mitigating interspecies viral transmission.
Emapalumab Treatment in Patients With Rheumatologic Disease–Associated Hemophagocytic Lymphohistiocytosis in the United States: A Retrospective Medical Chart Review Study
Authors: Chandrakasan Shanmuganathan , Allen Carl E. , Bhatla Deepika , Carter John , Chien May , Cooper Robert , Draper Lauren , Eckstein Olive S. , Hanna Rabi , Hays J. Allyson , Hermiston Michelle L. , Hinson Ashley P. , Hobday Patricia M. , Isakoff Michael S. , Jordan Michael B. , Leiding Jennifer W. , Modica Renee , Nakano Taizo A. , Oladapo Abiola , Patel Sachit A. , Pednekar Priti , Riskalla Mona , Sarangi Susmita N. , Satwani Prakash , Tandra Anand , Walkovich Kelly J. , Yee John D. , Zoref‐Lorenz Adi , Behrens Edward M. ,   the REAL‐HLH investigators
Published: September 2024

ObjectiveRheumatologic disease–associated hemophagocytic lymphohistiocytosis (HLH), a rare, life‐threatening, systemic hyperinflammatory syndrome, occurs as a complication of underlying rheumatologic disease. Real‐world evidence is lacking on emapalumab, a fully human monoclonal antibody that neutralizes the proinflammatory cytokine interferon‐γ, approved for treating patients with primary HLH.MethodsREAL‐HLH, a retrospective medical chart review study conducted across 33 US hospitals, assessed real‐world treatment patterns and outcomes in patients with HLH treated with one or more dose of emapalumab between November 20, 2018, and October 31, 2021. Data are presented for the subset of patients with rheumatologic disease–associated HLH.ResultsFifteen of 105 patients (14.3%) had rheumatologic disease–associated HLH. Of these, nine (60.0%) had systemic juvenile idiopathic arthritis, and one (6.7%) had adult‐onset Still disease. Median (range) age at HLH diagnosis was 5 (0.9–39) years. Most patients (9 of 15; 60.0%) initiated emapalumab in an intensive care unit. Emapalumab was most frequently initiated for treating refractory or recurrent (10 of 15; 66.7%) disease. Most patients received HLH‐related therapies before (10 of 15; 66.7%) and concurrently with (15 of 15; 100.0%) emapalumab. Emapalumab‐containing regimens stabilized or achieved physician‐determined normalization of most laboratory parameters, including absolute neutrophil count and absolute lymphocyte count (13 of 14; 92.9%), chemokine ligand 9 (9 of 11; 81.8%), and platelets and alanine transaminase (11 of 14; 78.6%), and reduced glucocorticoid dose by 80%. Overall survival and 12‐month survival probability from emapalumab initiation were 86.7%.ConclusionEmapalumab‐containing regimens stabilized or normalized most key laboratory parameters, reduced glucocorticoid dose, and were associated with low disease‐related mortality, thereby demonstrating potential benefits in patients with rheumatologic disease–associated HLH.
Escherichia coliin the production of biopharmaceuticals
Authors: İncir İbrahim , Kaplan Özlem 
Published: September 2024

AbstractEscherichia colihas shouldered a massive workload with the discovery of recombinant DNA technology. A new era began in the biopharmaceutical industry with the production of insulin, the first recombinant protein, inE. coliand its use in treating diabetes. After insulin, many biopharmaceuticals produced fromE. colihave been approved by the US Food and Drug Administration and the European Medicines Agency to treat various human diseases. AlthoughE. colihas some disadvantages, such as lack of post‐translational modifications and toxicity, it is an important host with advantages such as being a well‐known bacterium in recombinant protein production, cheap, simple production system, and high yield. This study examined biopharmaceuticals produced and approved inE. coliunder the headings of peptides, hormones, enzymes, fusion proteins, antibody fragments, vaccines, and other pharmaceuticals. The topics on which these biopharmaceuticals were approved for treating human diseases, when and by which company they were produced, and their use and development in the field are included.
Industry 4.0 adoption and eco‐product innovation capability—Understanding the role of supply chain integration
Authors: Sahoo Saumyaranjan , Kumar Ashwani , Kumar Mangla Sachin , Tiwari Anurag 
Published: September 2024

AbstractEmploying Industry 4.0 technologies has been recognized to facilitate data‐driven decision‐making and real‐time operational insights. While such technologies are poised to streamline supply chains for increased efficiency, the nexus between these technologies and environmental sustainability remains underexplored. This study applies the resource‐based view and network theories to assess the role of Industry 4.0 in fostering eco‐product innovation through supply chain integration. Data from 496 Indian manufacturing firms were analyzed using structural equation modeling to probe the relationships between Industry 4.0 adoption, supply chain integration, and eco‐product innovation capability. Results demonstrate that Industry 4.0 technologies have a positive direct effect on supply chain integration. However, when considering the capability for eco‐product innovation, the role of Industry 4.0 is contingent upon the degree of supply chain integration at upstream, internal, and downstream stages. The findings reveal that supply chain integration acts as a pivotal mediator in harnessing Industry 4.0 for eco‐product innovation. The direct influence of Industry 4.0 on eco‐innovation capability was found to be insignificant, underscoring the integrated approach to supply chain management as critical for environmental advancements. This work contributes a nuanced understanding of how manufacturers can strategically employ Industry 4.0 to bolster their environmental and competitive positioning, providing a comprehensive framework for enhancing eco‐product innovation capability.
Global, regional, and national burdens of leukemia from 1990 to 2019: A systematic analysis of the global burden of disease in 2019 based on the APC model
Authors: Qu Xiang , Zheng Anjie , Yang Jie , Zhang Jinru , Qiao Hongmei , Jiang Fan , Zhao Jie , Wang Chunping , Ning Peng 
Published: September 2024

AbstractBackgroundLeukemia is the tenth most common cause of cancer death worldwide and one of the most important causes of disability. To understand the current status and changing trends of the disease burden of leukemia at the global, regional, and national levels, and to provide a scientific basis for the development of leukemia prevention and treatment strategies.MethodsBased on open data from the Global Burden of Disease Study 2019 (GBD 2019), R software was used to calculate estimated annual percentage changes to estimate trends in the age‐standardized incidence (ASIR) and the age‐standardized disability‐adjusted life years (DALY) rate due to leukemia and its major subtypes from 1990 to 2019.ResultsIn 2019, globally, the number of incidences and DALYs of leukemia were 643.6 × 103 (587.0 × 103, 699.7 × 103) and 11,657.5 × 103 (10529.1 × 103, 12700.7 × 103), respectively. The ASIR (estimated annual percentage change (EAPC) = −0.37, 95%UI −0.46 to −0.28) and the age‐standardized DALY rate (EAPC = −1.72, 95%UI −1.80 to −1.65) of leukemia showed a decreasing trend from 1990 to 2019. The APC model analysis showed that the age effect of leukemia risk was a “U”‐shaped distribution of relative risk (RR) with increasing age from 1990 to 2019, globally. The time effect was an increase in incidence rate with increasing years but a decrease in DALY rate with increasing years. The cohort effects of both incidence and DALY rates tended to increase and then decrease with the development of the birth cohort. In 1990 and 2019, smoking, high body‐mass index, occupational exposure to benzene, and occupational exposure to formaldehyde were risk factors for DALY in leukemia, especially in areas with high SDI.ConclusionsFrom 1990 to 2019, the disease burden of leukemia showed a decreasing trend, but it is worth noting that its overall severity is still very high. The disease burden of leukemia varies greatly from region to region, and exclusive strategies for the prevention and treatment of leukemia should be developed according to the economic and cultural development of each region.
Pericardial tamponade in coronary interventions: Morbidity and mortality
Authors: Deshpande Saurabh , Sawatari Hiroyuki , Rangan Kapil , Buchade Anusha , Ahmed Raheel , Ramphul Kamleshun , Ahmed Mushood , Khanji Mohammed Y. , Somers Virend K. , Shahid Farhan , Chahal Anwar A. , Padmanabhan Deepak 
Published: September 2024

AbstractBackgroundCardiac tamponade or pericardial tamponade (PT) can be a complication following invasive cardiac procedures.MethodsPatients who underwent various procedures in the cardiac catheterization lab (viz. coronary interventions) were identified using the International Classification of Diseases, Ninth and Tenth Edition, Clinical Modification (International classification of diseases [ICD]‐9‐Clinical modification [CM] and ICD‐10‐CM, respectively) from the Nationwide Inpatient Sample (NIS) database. Patient demographics, presence of comorbidities, PT‐related events, and in‐hospital death were also abstracted from the NIS database.ResultsThe frequency of PT‐related events in the patients undergoing CI from 2010 to 2017 ranged from 3.3% to 8.4%. Combined in‐hospital mortality/morbidity of PT‐related events were higher with increasing age (odds ratio [OR] [95% CI]: chronic total occlusion (CTO) = 1.19 [1.10‐1.29]; acute coronary syndrome (ACS) = 1.21 [1.11‐1.33], both p < 0.0001) and female sex (OR [95%CI]: CTO = 1.70 [1.45‐2.00]; ACS = 1.72 [1.44‐2.06], both p < 0.0001). In‐hospital mortality related to PT‐related events was found to be 8.5% for coronary procedures. In‐hospital mortality was highest amongst the patients undergoing percutaneous transluminal coronary angioplasty (PTCA) for ACS (ACS vs. non‐CTO PTCA vs. CTO PTCA: 15.7% vs. 10.4% and 14.4%, p < 0.0001 and ACS vs. non‐CTO PTCA vs. CTO PTCA: 12.1% vs. 8.1% and 5.6%, p = 0.0001, respectively).ConclusionsIn the real‐world setting, PT‐related events in CI were found to be 3.3%−8.4%, with in‐hospital mortality of 8.5%. The patients undergoing PTCA for ACS were found to have highest mortality. Older patients undergoing CTO PTCA independently predicted higher mortality.
MDMA(“Ecstasy”) abuse leading to delayed onset rhabdomyolysis: A case report and literature review
Authors: Gautam Swotantra , Neupane Aakash , Molina Ivonne De La Hoz , Villarreal Jhonny Bonilla , Li Weiying , Mahmud Tasnuva Anindita H. 
Published: September 2024

Key Clinical MessageMDMA and cocaine can result in acute onset rhabdomyolysis. However, delayed onset rhabdomyolysis and its pathophysiology is of concern Early therapeutic intervention improves prognosis. Such cases should be promptly referred and managed in centers equipped with critical care and renal replacement therapy.
Antecedents of mentors’ interpersonal behaviors at work: A cross‐sectional study
Authors: Firzly Najat , Goulet‐Pelletier Jean‐Christophe , Pelletier Luc , Lagacé Martine 
Published: September 2024

AbstractBuilding on the self‐determination theory and the work of Pelletier and their colleagues, we conducted a study to examine the antecedents of mentors’ interpersonal behaviors. The purpose of this study was to determine how influence from above (administrative, practice, and colleagues’ pressures) and influence from below (perception of mentees’ level of self‐determined motivation) were related to the mentors’ motivations for their work and the mentoring relationship, and how the mentors’ motivations were related to their interpersonal behaviors. In the present study (N = 600), the results of a cross‐sectional design showed that mentors who perceived greater influence from above and lower influence from below were more non‐self‐determined toward their work and the mentoring relationship. In turn, the more non‐self‐determined they were, the more they were acting in a controlling manner with their mentees. Overall, our findings supported the independent and complementary role of influences from above and from below on mentors’ motivations and interpersonal behaviors.
Luminescence Changeable CO2‐Storage Cylinder: Triple‐Stranded Helical Eu(III)/Tb(III) Fluorinated MOFs with Amide Linkers
Authors: Hayashi Joe , Iwamura Shinichiro , Nakasaka Yuta , Wang Mengfei , Shoji Sunao , Kitagawa Yuichi , Fushimi Koji , Mukai Shin R. , Hasegawa Yasuchika 
Published: September 2024

AbstractTriple‐stranded helical lanthanide MOFs with CO2 adsorption properties were investigated. Lanthanide MOFs ([Eu0.1Tb0.9(hfa)3(dpa)]n) are composed of lanthanide luminophores (Eu(III) and/or Tb(III) ions), fluorinated antenna ligands (hfa: hexafluoroacetylacetonate), and polyamide‐type linker ligands (dpa: 4‐(diphenylphosphoryl)‐N‐(4‐(diphenylphosphoryl)phenyl)benzamide). The cylindrical structure was characterized by single‐crystal X‐ray analysis, thermogravimetric analysis, and gas adsorption measurements. The inner surfaces of the cylindrical channels were covered with the fluorine atoms of the hfa ligands. The emission intensity ratio (IEu/ITb) in [Eu0.1Tb0.9(hfa)3(dpa)]n is affected by the CO2 gas adsorption behavior. The change in IEu/ITb value was caused by the intermolecular interactions between the CO2 gas molecules and the fluorinated ligands, resulting in an electronic structural change of the lowest triplet excited state in the photosensitized hfa ligands.
Virtual Engineering: Hands‐on Integration of Product Lifecycle Management, Computer‐Aided Design, eXtended Reality, and Artificial Intelligence in Engineering Education
Authors: Bönsch Jakob , Greif Lucas , Hauck Svenja , Kreuzwieser Simon , Mayer Anjela , Michels Felix Longge , Ovtcharova Jivka 
Published: September 2024

AbstractEngineering education at the Institute for Information Management in Engineering integrates product lifecycle management (PLM), computer‐aided design (CAD), eXtended reality (XR), and artificial intelligence (AI) to enhance learning and prepare students for modern challenges. Our interdisciplinary approach, emphasizing digital twins and virtual twins, fosters immersive, hands‐on experiences. This paper reviews our strategies, comparing them with global initiatives, highlighting the transformative impact of our curriculum on preparing future engineers for complex industrial environments.
DBFact applied to minimum variance performance assessment for nonminimum phase multivariate systems from closed‐loop data
Authors: Lima Maria , Trierweiler Jorge Otávio , Farenzena Marcelo 
Published: September 2024

AbstractThis paper introduces an approach for determining a minimum variance control (MVC) benchmark for nonminimum phase (NMP) multi‐input multi‐output (MIMO) systems using closed‐loop operational data. The MVC benchmark is derived from the MVC law of DBFact factorization introduced by Lima, Trierweiler, and Farenzena. Unlike other factorization methods, DBFact offers advantages such as non‐iterative computation and ensuring internal stability of the MVC law. This approach considers the inherent directionality of NMP MIMO systems, enhancing the reliability of the control performance index. However, the original method relies on prior knowledge of the process model. To overcome this limitation, this paper proposes a method for calculating the MVC benchmark when prior knowledge is absent. It introduces a MIMO system identification strategy employing minimally invasive signal tests. The methodology is evaluated across various control conditions using a quadruple‐tank plant with additional time delays. The study emphasizes the importance of directionality in assessing MIMO system performance, particularly in evaluating individual loop performances. Results demonstrate the identification procedure's effectiveness in accurately calculating the proposed MVC benchmark, even with a mere 1% increase in output variance considered.
An Oxygen‐Self‐Produced Nanoplatform Based on MnO2 for Relieving Hypoxia
Authors: Pan Guohua , Bao Hanxiao , Zhang Jinguo , Hou Jue , Zhou Jun , Bai Hongzhen , Tang Guping 
Published: September 2024

AbstractManganese dioxide (MnO2) nanoparticles are increasingly recognized for their potential in biomedical applications, particularly in the realm of hypoxic cancer therapy, due to their unique physicochemical characteristics. This investigation introduces a novel, template‐free synthesis strategy. The reducing groups inherent in bovine serum albumin (BSA) facilitate a redox reaction with potassium permanganate (KMnO4), while the abundance of functional groups in BSA is instrumental in the formation of MnO2. The transmission electron microscopy (TEM) analysis has characterized the synthesized MnO2 nanoparticles, termed BM NPs, as spherical particles with a mean diameter of 210 nm and zeta potential of −40.1 mV measured by dynamic light scattering (DLS). The Fourier transform infrared (FT‐IR) spectrum of BM NPs exhibits the characteristic peak of MnO2 at 1113 cm−1 and 620 cm−1. Furthermore, the elemental composition of BM NPs has been ascertained through energy‐dispersive X‐ray (EDX) elemental mapping analysis. Though concentration of BM NPs up to 200 μg/mL, the survival rate of 4T1 cells remained approximately 75 %. Given that BM NPs at a concentration of 100 μg/mL significantly alleviate cellular hypoxia, the high oxygen‐generating capacity of these nanoparticles is proved, suggesting their suitability as a drug delivery system, especially in the context of hypoxic tumor microenvironments.