bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of outcomes of patients with inpatient or outpatient onset ischemic stroke
Authors: Bekelis Kimon , Missios Symeon , Coy Shannon , MacKenzie Todd A 
Published: February 2016

BackgroundReperfusion times for ischemic stroke occurring in the outpatient setting have improved significantly in recent years. However, quality improvement efforts have largely ignored ischemic stroke occurring in patients hospitalized for unrelated indications.MethodsWe performed a cohort study involving patients with ischemic stroke (with inpatient or outpatient onset) from 2009 to 2013 who were registered in the Statewide Planning and Research Cooperative System (SPARCS) database. A propensity score-adjusted regression analysis was used to assess the association of location of onset and outcomes. Mixed effects methods were employed to control for clustering at the hospital level.ResultsOf the 176 571 ischemic strokes, 160 157 (90.7%) occurred outside of a hospital and 16 414 (9.3%) occurred in patients hospitalized for unrelated indications. Using a logistic regression model with propensity score adjustment, we demonstrated that inpatient stroke onset was associated with increased inpatient mortality (OR 3.09; 95% CI 2.81 to 3.38), rate of discharge to rehabilitation (OR 2.57; 95% CI 2.37 to 2.79), and length of stay (LOS) (β=11.58; 95% CI 10.73 to 12.42). In addition, it was associated with lower odds (OR 0.69; 95% CI 0.62 to 0.77) of undergoing stroke-related interventions (mechanical thrombectomy and intravenous tissue plasminogen activator) compared with outpatient stroke onset.ConclusionsUsing a comprehensive all-payer cohort of patients with ischemic stroke in New York State, we identified an association of inpatient stroke onset with fewer stroke-related interventions and increased mortality, rate of discharge to rehabilitation, and LOS.
Integrated Patient Coordination System (IntPaCS): a bespoke tool for surgical patient management
Authors: Chopra Shiv , Hachach-Haram Nadine , Baird Daniel L H , Elliott Katherine , Lykostratis Harry , Renton Sophie , Shalhoub Joseph 
Published: February 2016

AbstractBackgroundEfficient handover of patient information is fundamental for patient care and service efficiency. An audit exploring surgeons' views on written handover within a Trust's surgical specialties concluded that clear deficiencies existed. Such concerns have been echoed in the General Medical Council's guidance on safe surgical handover.AimsTo design and implement bespoke software for surgical handover using the audit results of surgeons' perceptions of existing processes. To gain feedback from the surgical department on this new software and implement a long-term sustainability strategy.MethodsFollowing an initial review, a proposal was presented for a new patient management tool. The software was designed and developed in-house to reflect the needs of our surgeons. The bespoke programme used open-source coding and was maintained on a secure server. A review of surgical handover occurred 12 and 134 weeks post-implementation of the new software.ResultsIntegrated Patient Coordination System (IntPaCS) was successfully developed and delivered. The system is a centralised platform that enables the visualisation, handover and audit/research of surgical inpatient information in any part of the hospital. Feedback found that clinicians found it less stressful to create a post-take handover (60% vs 36%) than using a Word document. IntPaCS was found to be quicker to use too (15 min (SD 4) vs 24 min (SD 7.5)). Finally, the new system was considered safer with less reported missing/incorrect patient data (48% vs 9%).ConclusionsThis study has shown that careful use of emerging technology and innovation over time has the potential to improve all aspects of clinical governance.
Linear Software Models: Decoupled Modules from Modularity Matrix Eigenvectors
Authors: Exman Iaakov 
Published: February 2016

Modularity Matrices for software systems can be put in block-diagonal form, where blocks are higher-level software modules, in a hierarchy of modules. But the exact module boundaries are often blurred by the uncertainty whether given matrix elements are module members or outliers. This paper provides an algorithm to determine module sizes. As a consequence the algorithm also decides which matrix elements are outliers. Matrix elements are weighted by their Affinity — an exponential function of the off-diagonality. The module size is given by the positive consecutive elements of the eigenvectors corresponding to the largest eigenvalues of this weighted symmetrized Modularity Matrix. By means of case studies, we illustrate the idea that outliers not only indicate the need for system redesign, but explicitly point out to problematic design spots. This work extends the applicability of linear algebra spectral methods to Modularity Matrices, at higher software abstraction levels than previously shown.
Atrial Fibrillation Is Associated With Increased Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement
Authors: Biviano Angelo B. , Nazif Tamim , Dizon Jose , Garan Hasan , Fleitman Jessica , Hassan Dua , Kapadia Samir , Babaliaros Vasilis , Xu Ke , Parvataneni Rupa , Rodes-Cabau Josep , Szeto Wilson Y. , Fearon William F. , Dvir Danny , Dewey Todd , Williams Mathew , Mack Michael J. , Webb John G. , Miller D. Craig , Smith Craig R. , Leon Martin B. , Kodali Susheel 
Published: February 2016

Background—
This study sought to evaluate the impact of atrial fibrillation (AF) on clinical outcomes in patients undergoing transcatheter aortic valve replacement.

Methods and Results—

Data were evaluated in 1879 patients with baseline and discharge ECGs who underwent transcatheter aortic valve replacement in the Placement of AoRTic TraNscathetER Valve (PARTNER) trial. A total of 1262 patients manifested sinus rhythm (SR) at baseline/SR at discharge, 113 SR baseline/AF discharge, and 470 AF baseline/AF discharge. Patients who converted from SR to AF by discharge had the highest rates of all-cause mortality at 30 days (
P
<0.0001 across all groups; 14.2% SR/AF versus 2.6% SR/SR; adjusted hazard ratio [HR]=3.41;
P
=0.0002) and over 2-fold difference at 1 year (
P
<0.0001 across all groups; 35.7% SR/AF versus 15.8% SR/SR; adjusted HR=2.14;
P
<0.0001). The presence of AF on baseline or discharge ECG was a predictor of 1-year mortality (adjusted HR=2.14 for SR/AF group and HR=1.88 for AF/AF groups;
P
<0.0001 for both groups versus SR/SR). For patients discharged in AF, those with lower ventricular response (ie, <90 bpm) experienced less 1-year all-cause mortality (HR=0.74;
P
=0.04).

Conclusions—
After transcatheter aortic valve replacement, the presence of AF at discharge, and particularly, the conversion to AF by discharge and higher ventricular response are associated with increased mortality. These data underscore the deleterious impact of AF, as well as the need for targeted interventions to improve clinical outcomes, in patients undergoing transcatheter aortic valve replacement.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00530894.
Progress in the trans-Reduction and trans-Hydrometalation of Internal Alkynes. Applications to Natural Product Synthesis
Authors: Frihed Tobias Gylling , Fürstner Alois 
Published: February 2016

Abstract
The classical repertoire of synthetic organic chemistry is short of methods that allow triple bonds to be transformed into (E)-alkenes with high selectivity in the presence of other reducible sites. Recent advances, most notably in ruthenium-catalyzed trans-hydrogenation, trans-hydrosilylation, trans-hydrogermylation, trans-hydrostannation, and even trans-hydroboration hold the promise of filling this gap. This review illustrates the state-of-the-art in the field by summarizing applications of these emerging methodologies to natural product synthesis. A comparison of ruthenium-catalyzed and radical-induced trans-hydrostannations provides further insights into the application profile of these transformations.
Συγκριτική μελέτη παραγωγής γραπτών αφηγήσεων μέσω τεχνικών υψηλής καθοδήγησης σε μαθητές Δ΄- ΣΤ΄ δημοτικού
Authors: Xanthi Styliani 
Published: February 2016

<p>Έρευνες έχουν δείξει ότι οι μαθητές με μαθησιακές δυσκολίες αντιμετωπίζουν ιδιαίτερες δυσκολίες κατά την παραγωγή γραπτού λόγου που αφορούν το σχεδιασμό, την καταγραφή, την επανεξέταση και την επιμέλεια ενός κειμένου. Ακόμη από πολλούς μελετητές υποστηρίζεται ότι ο εκπαιδευτικός μέσα από τεχνικές καθοδήγησης της γραπτής έκφρασης, μπορεί να βοηθήσει ουσιαστικά τους μαθητές. Σκοπός της εργασίας ήταν η αξιολόγηση συγκεκριμένων δεξιοτήτων παραγωγής γραπτών αφηγήσεων, στις οποίες έχει φανεί από έρευνες ότι οι μαθητές με μαθησιακές δυσκολίες παρουσιάζουν αδυναμίες και χαμηλές επιδόσεις, και η διερεύνηση της βοήθειας που μπορεί να προσφέρουν δύο τεχνικές υψηλής καθοδήγησης. Για τον σκοπό αυτό 89 μαθητές Δημοτικού τετάρτης, πέμπτης και έκτης τάξης, 22 με υψηλή σχολική επίδοση και 67 με μαθησιακές δυσκολίες, έγραψαν ένα κείμενο με την τεχνική των εικόνων και ένα με την τεχνική ημιτελών και ανακατεμένων φράσεων. Η αξιολόγηση των κειμένων των μαθητών σε επίπεδο λέξης, πρότασης, παραγράφου, συνολικής δομής του κειμένου και περιεχομένου έδειξε ότι οι μαθητές με υψηλή σχολική επίδοση παρουσίασαν πολύ καλύτερο επίπεδο αφηγηματικής ικανότητας. Και οι δύο ομάδες των μαθητών βοηθήθηκαν περισσότερο από την τεχνική ημιτελών και ανακατεμένων φράσεων. Με βάση αυτά τα ευρήματα η εργασία πραγματεύεται τρόπους βοήθειας και πλαίσια στήριξης μέσω των οποίων οι μαθητές βοηθιούνται στην παραγωγή γραπτών αφηγήσεων.</p>
Αειφόρο ελληνικό σχολείο
Authors: Trikaliti Aggeliki 
Published: February 2016

Το Πρόγραμμα Αειφόρο Ελληνικό Σχολείο είναι ένα πρόγραμμα που προωθεί τη φιλοσοφία του αειφόρου σχολείου. Το αειφόρο σχολείο λειτουργεί ως Κοινότητα, στοχεύοντας να δημιουργήσει το κατάλληλο σχολικό κλίμα στο οποίο ενθαρρύνεται η ενασχόληση όλων με τα κοινά και τη διαχείρισή τους, υπηρετείται η δημοκρατία και τα ανθρώπινα δικαιώματα, προάγεται η μάθηση, ο πολιτισμός, η αειφόρος ανάπτυξη, η υγεία και διαμορφώνονται ενεργοί και δημιουργικοί πολίτες.<strong> </strong>Το πρόγραμμα Αειφόρο Ελληνικό Σχολείο προσπαθεί να ενεργοποιήσει μηχανισμούς μετασχηματισμού του σχολείου σε αειφόρο. Υιοθετείται η ολιστική προσέγγιση του σχολείου ως οργανισμού και για να ενθαρρυνθούν οι εκπαιδευτικοί<strong> </strong>να<strong> </strong>εμπλακούν σταδιακά σε διαδικασίες μετασχηματισμού του σχολείου τους και να παρακολουθούν την πορεία των αλλαγών που επιφέρουν η αειφορία στο σχολείο κατανέμεται και οργανώνεται γύρω από οκτώ πυλώνες.<strong> </strong>Οι οκτώ πυλώνες είναι: δημοκρατία και συμμετοχή, πλαίσιο μάθησης, πολιτισμός και τέχνες, κτίριο και αυλή, ενέργεια και μετακινήσεις, νερό και απορρίμματα, υγεία και διατροφή, από το τοπικό στο παγκόσμιο
Cowpea Mild Mottle Virus (CpMMV) infection and its effect to performance of South Korean soybean varieties
Authors: SUTRISNO SUTRISNO , KUSWANTORO HERU 
Published: February 2016

Sutrisno, Kuswantoro H. 2016. Cowpea Mild Mottle Virus (CpMMV) infection and its effect to performance of South Korean soybean varieties. Biodiversitas 17: 129-133. Cowpea Mild Mottle Virus (CpMMV) is a very detrimental disease to soybean. This virus infection can cause yield reduction up to 56%. Introduction varieties can be served as alternative material in breeding program to develop resistant variety. This study aimed to evaluate the response of introduction soybean varieties from South Korea to the CpMMV infection. Ten South Korean soybean varieties and two check Indonesian soybean varieties were grown at ILETRI from August to November 2012. CpMMV infection was carried out by natural infection using whitefly (Bemisia tabaci) transmission. The results showed that the South Korean variety of Daemang-2 had lower leave malformation level than two Indonesian varieties. Varieties of Cheongja-3, Daemang, Daehwang, Daewon, Danweon, Geomjeong-3 Geonjeongsaeol produced grain yield that equal to Anjasmoro variety. Daepung was the most resistant to CpMMV than other varieties, but having low grain yield. Daemang-2 was the most tolerantÂ to CpMMV, because it still able to produce high grain yield although showing high leaf infection. These two varieties could be used as gene sources for resistant/tolerant to CpMMV in soybean breeding program.
“Everyone Here Knows a Junior”: Blackfoot Children and Their Books
Authors: Spring Erin 
Published: February 2016

This column focuses on the early stages of my participatory, reader-response research with First Nations youth living on a reserve in Alberta. I am interested in the ways in which young readers reflect on their social, cultural, and place-based identities while reading culturally relevant, local fiction. I focus on the methodological design of my project, which includes reading discussion groups and the creation of place-journals. I reflect on the process of finding suitable research texts.
The Moral Sentiments in Hume’s Treatise : A Classificatory Problem
Authors: Carlson Åsa 
Published: February 2016

In the Treatise , Hume writes several seemingly incompatible things about the moral sentiments, thus there is no general agreement about where they fit within his taxonomy of the perceptions. Some passages speak in favor of the view that moral sentiments are indirect passions, a few in favor of the view that they are direct passions, and yet a couple of explicit statements strongly suggest otherwise. Due to these tensions in Hume’s text, we find at least five competing characterizations in the literature: •
Moral sentiments are calm emotions.
•
Moral sentiments are calm direct passions.
•
Moral sentiments are calm versions of the indirect passions of love or hatred.
•
Moral sentiments are unique species of calm indirect passions.
•
Moral sentiments are indirect secondary impressions.

This paper assesses each of these interpretations. When their virtues are brought together, a new interpretation of the origin of moral sentiments starts to emerge.
Excessive interatrial adiposity is associated with left atrial remodeling, augmented contractile performance in asymptomatic population
Authors: Lai Yau-Huei , Yun Chun-Ho , Su Cheng-Huang , Yang Fei-Shih , Yeh Hung-I , Hou Charles Jia-Yin , Wu Tung-Hsin , Cury Ricardo C. , Bezerra Hiram G. , Hung Chung-Lieh 
Published: February 2016

Abstract
Purpose: Pericardial adipose tissue had been shown to exert local effects on adjacent cardiac structures. Data regarding the mechanistic link between such measures and left atrial (LA) structural/functional remodeling, a clinical hallmark of early stage heart failure (HF) and atrial fibrillation (AF) incidence, in asymptomatic population remain largely unexplored.
Methods: This retrospective analysis includes 356 subjects free from significant valvular disorders, atrial fibrillation, or clinical HF. Regional adipose tissue including pericardial and periaortic fat volumes, interatrial septal (IAS), and left atrioventricular groove (AVG) fat thickness were all measured by multidetector computed tomography (MDCT) (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, p]USA). We measured LA volumes, booster performance, reservoir capacity as well as conduit function, and analyzed their association with adiposity measures.
Results: All four adiposity measures were positively associated with greater LA volumes (all P < 0.05), while IAS and AVG fat were also related to larger LA kinetic energy and worse reservoir capacity (both P < 0.01). In multivariate models, IAS fat thickness remained independently associated with larger LA volumes, increased LA kinetic energy and ejection force (ß-coef: 0.17 & 0.15, both P < 0.05), and impaired LA reservoir and conduit function (ß-coef: -0.20 & -0.12, both P < 0.05) after adjusting for clinical variables.
Conclusion: Accumulated visceral adiposity, especially interatrial fat depots, was associated with certain LA structural/functional remodeling characterized by impaired LA reservoir and conduit function though augmented kinetic energy and ejection performance. Our data suggested that interatrial fat burden may be associated with certain detrimental LA functions with compensatory LA adaptation in an asymptomatic population.
Pharmaceutical innovation and technological dependence: a study of the Brazilian scenario
Authors: Silva Ricardo Eccard da , Amato Angélica Amorim , Novaes Maria Rita Carvalho Garbi 
Published: February 2016

<p class="abstract"><strong>Background:</strong> Among other factors, a country’s pharmaceutical innovation and technological dependence is related to its ability to research and develop technology. Brazil imports pharmaceutical products and drugs, in order to meet the population’s needs. The present work’s objectives were to investigate whether the innovative drugs registered by the Brazilian Health Surveillance Agency (Anvisa) had been studied in the Brazilian population and, among those studied, to describe the profile of the clinical trials held.</p><p class="abstract"><strong>Methods:</strong> Documental and descriptive study. The data were obtained from databases: i) Anvisa’s Clinical Research Control System (SCPC) and ii) the Products and Services System in Health Surveillance (Datavisa).</p><p class="abstract"><strong>Results:</strong> Among the drugs registered, the following were observed: 90 new molecules, of which 42% (38) had been studied in the Brazilian population; 24 new combinations of drugs, of which 33% (8) had been studied in the Brazilian population; 23 new biological drugs, of which 61% (14) had been studied in the Brazilian population; 80 new herbal drugs, of which 5% (4) had been studied in the Brazilian population. In the development of new synthetic molecules, 76% (29) had been studied in trials with foreign cooperation. For the new biological drugs, 86% had been studied in trials with foreign cooperation. </p><strong>Conclusions:</strong> A large majority, therefore, of the studies of radical innovations (new molecules and new biological drugs) and incremental innovations (inclusion of new therapeutic indications) involve foreign cooperation, which shows foreign companies’ capacity for innovation in contrast with those of Brazil.
A proposed novel ultrasound-guided percutaneous dilatational tracheostomy technique - the in-plane wire-in-needle approach: study design and rationale for multicenteric randomized controlled clinical trial
Authors: Alansari Mariam A. , Al-Jamaan Fadi 
Published: February 2016

<p class="abstract"><strong><span lang="EN-US">Background: </span></strong>The current evidence regarding the applications of Ultra Sound (US) in Percutaneous Dilatational Tracheostomy (PDT) is encouraging. US guided PDT (US-PDT) has recently been recommended in difficult cases and is given a preference compared to bronchoscope guided PDT. The question on the difference in safety and efficacy of the different approaches in US-PDT (with or without the use of any technique to improve needle visualization) during US-PDT and whether it is likely to make a difference needs to be answered.</p><p class="abstract"><strong><span lang="EN-US">Methods: </span></strong>Literatures examining the different US-PDT approaches as well as whether any technique to improving needle visualization that has been used during US-PDT in MEDLINE, PubMed, EMBAS E, and the Cochrane Central Register of Controlled Trials were searched for in an attempt to answer the two questions raised. No study has yet compared the in plane to the out of plane approach for US-PDT nor looked at improving needle visualization during US-PDT. This raised the need for a clinical trial looking at the difference between the different US-PDT approaches with or without ways to improve needle visualization during US-PDT.</p><p class="abstract"><strong><span lang="EN-US">Results: </span></strong>Utilizing the best available evidence in US guided procedures in the Intensive Care Units (ICU), we proposed a study design that we think is likely to make a difference in US-PDT practice. The study is designed to assess the safety and efficacy of US guided PDT using the in-plane (I.P.) approach enhanced with the use of Wire-in-needle approach (W.I.N.A) and rocking motion of the transducer compared to the traditional out-of-plane approach without W.I.N.A.</p><p class="abstract"><strong><span lang="EN-US">Conclusions:</span></strong><span lang="EN-US"> The proposed (In-plane Wire-In-needle approach = I.P.W.I.N.A) as a potential to be a standard of care in US-PDT has its own limitations. Its safety, efficacy and feasibility in Randomized Controlled Clinical Trials research settings needs to be tested and verified.</span></p>
Crescimento inicial de ervilha sob diferentes níveis de compactação em dois tipos de solos
Authors: Silva A. L. , Matos A. C. B. , Hilst P. C. , Silva H. S. 
Published: February 2016

<p>O manejo do solo pode alterar as propriedades físicas do solo, sendo de grande importância para garantir o estabelecimento de plântulas e produtividade. A inovação de implementos e máquinas agrícolas e excesso de tratos culturais durante o manejo são os principais fatores que interferem nestas características. Assim, objetivou-se avaliar o efeito da compactação de solos com diferentes classes texturais (argilosa e muito argilosa) no crescimento inicial de ervilha. O experimento foi montado em casa de vegetação com sementes de ervilha Itapuã 600. Cada tratamento contou com 4 repetições de 50 sementes em diferentes graus de compactação dos solos, com aplicações três cargas sobre os solos que resultaram em: argiloso: controle: 0,21, T1: 0,26, T2: 0,28 e T3: 0,33 MPa, textura muito argilosa: controle: 0,40, T1: 0,42, T2: 0,46 e T3: 0,53 MPa. Foram avaliados a porcentagem de emergência, IVE, VE, comprimento de parte aérea e raiz, massa seca de parte aérea, raiz e massa seca total. Para as duas classes texturais a compactação teve influência sobre a massa seca da parte aérea no solo com textura argilosa e para IVE no solo com textura muito argilosa. Porém, ambos não tiveram relação direta com o nível de compactação.</p><p align="center"><strong><em>Initial growth of</em></strong><strong><em> pea under different compaction levels of two types of soils</em></strong></p><p><strong>Abstract: </strong>Soil management can alter the physical properties of the soil, being of great importance to ensure adequate levels of crop productivity. The innovation of agricultural implements and machinery and excess cultural practices during handling are the main factors that affect these characteristics. The objective of this study was to evaluate the effect of compaction of soils with different texture classes (clay and heavy clay) on the initial growth of pea. The experiment was conducted in a greenhouse at the Department of Fitotecnia at UFV. Itapuã 600 pea seeds were used. Each treatment consisted of 4 replicates of 50 seeds for each compression level (T1, T2, T3 and without compression) for the two soil textural classes. Were evaluated: emergency, IVE, VE, length of shoot and root dry weight of shoot, root mass and total dry mass. For both textural classes compaction is not observed influence on the parameters analyzed, except for dry weight of shoots in clayey soil, IVE in clayey soil. However, both were not directly related to the level of compression.</p><p><strong> </strong></p>