bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dielectric properties of complex magnetic field induced states in PbCuSO4(OH)2
Authors: Mack T. , Ruff A. , Krug von Nidda H.-A. , Loidl A. , Krohns S. 
Published: June 2017

AbstractSpin spirals, which coexist with collinear spin order in linarite PbCuSO4(OH)2, indicate electrical polarisation textures of spin-multipolar phases. We derive experimental evidence by a detailed investigation of the magnetic-field dependent dielectric and electric polarization properties at low temperatures. Linarite exhibits a quasi-one-dimensional frustrated S = ½ spin chain, which forms 3D spin-spiral order in zero magnetic field for T < 2.85 K. Recently, due to the monoclinic lattice of linarite with CuO2 ribbon chains, complex magnetic field induced states were found. These spin-multipolar phases, which compete with spin-density waves at low magnetic fields, exist in close vicinity to the transition from the spin spiral into field induced spin polarized state. Via antisymmetric Dzyaloshinskii-Moriya interaction spin-driven ferroelectricity develops in the spin-spirals state. Via electric polarization measurements this allows to prove the transitions into complex magnetic field induced phases. Thorough analyses of the temperature and magnetic field dependent dielectric properties of a naturally grown single crystalline sample provide a detailed (T,H) phase diagrams for the three different crystallographic directions.
Mobile nucleic acid amplification testing (mobiNAAT) for Chlamydia trachomatis screening in hospital emergency department settings
Authors: Shin D. J. , Athamanolap P. , Chen L. , Hardick J. , Lewis M. , Hsieh Y. H. , Rothman R. E. , Gaydos C. A. , Wang T. H. 
Published: June 2017

AbstractManagement of curable sexually-transmitted infections (STI) such as Chlamydia can be revolutionized by highly sensitive nucleic acid testing that is deployable at the point-of-care (POC). Here we report the development of a mobile nucleic acid amplification testing (mobiNAAT) platform utilizing a mobile phone and droplet magnetofluidics to deliver NAAT in a portable and accessible format. By using magnetic particles as a mobile substrate for nucleic acid capture and transport, fluid handling is reduced to particle translocation on a simple magnetofluidic cartridge assembled with reagents for nucleic acid purification and amplification. A mobile phone user interface operating in tandem with a portable Bluetooth-enabled cartridge-processing unit facilitates process integration. We tested 30 potentially Chlamydia trachomatis (CT)-infected patients in a hospital emergency department and confirmed that mobiNAAT showed 100% concordance with laboratory-based NAAT. Concurrent evaluation by a nontechnical study coordinator who received brief training via an embedded mobile app module demonstrated ease of use and reproducibility of the platform. This work demonstrates the potential of mobile nucleic acid testing in bridging the diagnostic gap between centralized laboratories and hospital emergency departments.
Mitochondrial genomes of two Australian fishflies with an evolutionary timescale of Chauliodinae
Authors: Yang Fan , Jiang Yunlan , Yang Ding , Liu Xingyue 
Published: June 2017

AbstractFishflies (Corydalidae: Chauliodinae) with a total of ca. 130 extant species are one of the major groups of the holometabolous insect order Megaloptera. As a group which originated during the Mesozoic, the phylogeny and historical biogeography of fishflies are of high interest. The previous hypothesis on the evolutionary history of fishflies was based primarily on morphological data. To further test the existing phylogenetic relationships and to understand the divergence pattern of fishflies, we conducted a molecule-based study. We determined the complete mitochondrial (mt) genomes of two Australian fishfly species, Archichauliodes deceptor Kimmins, 1954 and Protochauliodes biconicus Kimmins, 1954, both members of a major subgroup of Chauliodinae with high phylogenetic significance. A phylogenomic analysis was carried out based on 13 mt protein coding genes (PCGs) and two rRNAs genes from the megalopteran species with determined mt genomes. Both maximum likelihood and Bayesian inference analyses recovered the Dysmicohermes clade as the sister group of the Archichauliodes clade + the Protochauliodes clade, which is consistent with the previous morphology-based hypothesis. The divergence time estimation suggested that the divergence among the three major subgroups of fishflies occurred during the Late Jurassic and Early Cretaceous when the supercontinent Pangaea was undergoing sequential breakup.
Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice
Authors: Hashimoto Ken , Kodama Aya , Honda Takeshi , Hanashima Akira , Ujihara Yoshihiro , Murayama Takashi , Nishimatsu Shin-ichiro , Mohri Satoshi 
Published: June 2017

AbstractFetal cardiomyocytes actively proliferate to form the primitive heart in utero in mammals, but they stop dividing shortly after birth. The identification of essential molecules maintaining this active cardiomyocyte proliferation is indispensable for potential adult heart regeneration. A recent study has shown that this proliferation depends on a low fetal oxygen condition before the onset of breathing at birth. We have established an isolation protocol for mouse fetal cardiomyocytes, performed under strict low oxygen conditions to mimic the intrauterine environment, that gives the highest proliferative activities thus far reported. Oxygen exposure during isolation/culture markedly inhibited cell division and repressed cell cycle-promoting genes, and subsequent genome-wide analysis identified Fam64a as a novel regulatory molecule. Fam64a was abundantly expressed in hypoxic fetal cardiomyocyte nuclei, but this expression was drastically repressed by oxygen exposure, and in postnatal cardiomyocytes following the onset of breathing and the resulting elevation of oxygen tension. Fam64a knockdown inhibited and its overexpression enhanced cardiomyocyte proliferation. Expression of a non-degradable Fam64a mutant suggested that optimum Fam64a expression and subsequent degradation by anaphase-promoting complex/cyclosome (APC/C) during the metaphase-to-anaphase transition are required for fetal cardiomyocyte division. We propose that Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice.
Validity Examination of the Dissipative Quantum Model of Olfaction
Authors: Tirandaz Arash , Taher Ghahramani Farhad , Salari Vahid 
Published: June 2017

AbstractDespite some inconclusive experimental evidences for the vibrational model of olfaction, the validity of the model has not been examined yet and therefore it suffers from the lack of conclusive experimental support. Here, we generalize the model and propose a numerical analysis of the dissipative odorant-mediated inelastic electron tunneling mechanism of olfaction, to be used as a potential examination in experiments. Our analysis gives several predictions on the model such as efficiency of elastic and inelastic tunneling of electrons through odorants, sensitivity thresholds in terms of temperature and pressure, isotopic effect on sensitivity, and the chiral recognition for discrimination between the similar and different scents. Our predictions should yield new knowledge to design new experimental protocols for testing the validity of the model.
Moss survival through in situ cryptobiosis after six centuries of glacier burial
Authors: Cannone N. , Corinti T. , Malfasi F. , Gerola P. , Vianelli A. , Vanetti I. , Zaccara S. , Convey P. , Guglielmin M. 
Published: June 2017

AbstractCryptobiosis is a reversible ametabolic state of life characterized by the ceasing of all metabolic processes, allowing survival of periods of intense adverse conditions. Here we show that 1) entire moss individuals, dated by 14C, survived through cryptobiosis during six centuries of cold-based glacier burial in Antarctica, 2) after re-exposure due to glacier retreat, instead of dying (due to high rates of respiration supporting repair processes), at least some of these mosses were able to return to a metabolically active state and remain alive. Moss survival was assessed through growth experiments and, for the first time, through vitality measurements. Future investigations on the genetic pathways involved in cryptobiosis and the subsequent recovery mechanisms will provide key information on their applicability to other systematic groups, with implications for fields as divergent as medicine, biodiversity conservation, agriculture and space exploration.
Improving transportation networks: Effects of population structure and decision making policies
Authors: Pablo-Martí Federico , Sánchez Angel 
Published: June 2017

AbstractTransportation networks are one of the fundamental tools for human society to work, more so in our globalized world. The importance of a correct, efficient design of a transportation network for a given region or country cannot be overstated. We here study how network design is affected by the geography of the towns or nuclei to be connected, and also by the decision process necessary to choose which connections should be improved (in a generic sense) first. We begin by establishing that Delaunay networks provide an efficient starting point for the network design and at the same time allow us to introduce a computationally amenable model. Subsequent improvements lead to decentralized designs in geographies where towns are more or less homogeneously distributed, whereas radial designs arise when there is a core-periphery distribution of nodes. We also show that optimization of Delaunay networks outperforms that of complete networks at a lower cost, by allowing for a proper selection of the links to improve. In closing, we draw conclusions relevant to policy making applied to designing transportation networks and point our how our study can be useful to identify mechanisms relevant to the historical development of a region.
Surface modification of pig endothelial cells with a branched heparin conjugate improves their compatibility with human blood
Authors: Bongoni Anjan K. , Salvaris Evelyn , Nordling Sofia , Klymiuk Nikolai , Wolf Eckhard , Ayares David L. , Rieben Robert , Magnusson Peetra U. , Cowan Peter J. 
Published: June 2017

AbstractCorline Heparin Conjugate (CHC), a compound of multiple unfractionated heparin chains, coats cells with a glycocalyx-like layer and may inhibit (xeno)transplant-associated activation of the plasma cascade systems. Here, we investigated the use of CHC to protect WT and genetically modified (GTKO.hCD46.hTBM) pig aortic endothelial cells (PAEC) in two pig-to-human in vitro xenotransplantation settings. Model 1: incubation of untreated or hTNFα-treated PAEC with 10% human plasma induced complement C3b/c and C5b-9 deposition, cellular activation and coagulation activation in WT and GTKO.hCD46.hTBM PAEC. Coating of untreated or hTNFα-treated PAEC with CHC (100 µg/ml) protected against human plasma-induced endothelial activation and damage. Model 2: PAEC were grown on microcarrier beads, coated with CHC, and incubated with non-anticoagulated whole human blood. Genetically modified PAEC significantly prolonged clotting time of human blood (115.0 ± 16.1 min, p < 0.001) compared to WT PAEC (34.0 ± 8.2 min). Surface CHC significantly improved the human blood compatibility of PAEC, as shown by increased clotting time (WT: 84.3 ± 11.3 min, p < 0.001; GTKO.hCD46.hTBM: 146.2 ± 20.4 min, p < 0.05) and reduced platelet adhesion, complement activation, coagulation activation and inhibition of fibrinolysis. The combination of CHC coating and genetic modification provided the greatest compatibility with human blood, suggesting that pre-transplant perfusion of genetically modified porcine organs with CHC may benefit post-transplant xenograft function.
Accurate strain sensing based on super-mode interference in strongly coupled multi-core optical fibres
Authors: Villatoro Joel , Arrizabalaga Oskar , Durana Gaizka , Sáez de Ocáriz Idurre , Antonio-Lopez Enrique , Zubia Joseba , Schülzgen Axel , Amezcua-Correa Rodrigo 
Published: June 2017

AbstractWe report on the use of a multi-core fibre (MCF) comprising strongly-coupled cores for accurate strain sensing. Our MCF is designed to mode match a standard single mode optical fibre. This allows us to fabricate simple MCF interferometers whose interrogation is carried out with light sources, detectors and fibre components readily available from the optical communications tool box. Our MCF interferometers were used for sensing strain. The sensor calibration was carried out in a high-fidelity aerospace test laboratory. In addition, a packaged MCF interferometer was transferred into field trials to validate its performance under deployment conditions, specifically the sensors were installed in a historical iron bridge. Our results suggest that the MCF strain sensors here proposed are likely to reach the readiness level to compete with other mature sensor technologies, hence to find commercial application. An important advantage of our MCF interferometers is their capability to operate at very high temperatures.
Brain functional connectivity difference in the complete network of an entire village: the role of social network size and embeddedness
Authors: Joo Won-tak , Kwak Seyul , Youm Yoosik , Chey Jeanyung 
Published: June 2017

AbstractSocial networks are known to protect cognitive function in old age. For the first time, this study examines how social network size and social network embeddedness measured by k-core score are associated with functional connectivity in the brain using the complete social network of an entire village. According to the results, social network size has both positive and negative associations with functional connectivity; showing no meaningful pattern relative to distance among brain regions. However, older adults deeply embedded in the complete network tend to maintain functional connectivity between long-distance regions even after controlling for other covariates such as age, gender, education, and Mini-Mental State Examination score. Network Based Statistics (NBS) also revealed strong and consistent evidence that social network embeddedness has component-level associations with functional connectivity among brain regions, especially between inferior prefrontal and occipital/parietal lobes.
Dmrt1 is required for primary male sexual differentiation in Chinese soft-shelled turtle Pelodiscus sinensis
Authors: Sun Wei , Cai Han , Zhang Gloria , Zhang Haiyan , Bao Haisheng , Wang Li , Ye Jian , Qian Guoying , Ge Chutian 
Published: June 2017

AbstractIn vertebrates, the primary sex-determining signals that initiate sexual development are remarkably diverse, ranging from complete genetic to environmental cues. However, no sex determination-related genes have been functionally identified in reptiles. Here, we characterized a conserved DM domain gene, Dmrt1, in Chinese soft-shelled turtle Pelodiscus sinensis (P. sinensis), which exhibits ZZ/ZW sex chromosomes. Dmrt1 exhibited early male-specific embryonic expression, preceding the onset of gonadal sex differentiation. The expression of Dmrt1 was induced in ZW embryonic gonads that were masculinized by aromatase inhibitor treatment. Dmrt1 knockdown in ZZ embryos by RNA interference resulted in male to female sex reversal, characterized by obvious feminization of gonads, significant down-regulation of testicular markers Amh and Sox9, and remarkable up-regulation of ovarian regulators, Cyp19a1 and Foxl2. Conversely, ectopic expression of Dmrt1 led to largely masculinized genetic females, production of Amh and Sox9, and a decline in Cyp19a1 and Foxl2. These findings demonstrate that Dmrt1 is both necessary and sufficient to initiate testicular development, thereby acting as an upstream regulator of the male pathway in P. sinensis.
MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals
Authors: Donati Benedetta , Dongiovanni Paola , Romeo Stefano , Meroni Marica , McCain Misti , Miele Luca , Petta Salvatore , Maier Silvia , Rosso Chiara , De Luca Laura , Vanni Ester , Grimaudo Stefania , Romagnoli Renato , Colli Fabio , Ferri Flaminia , Mancina Rosellina Margherita , Iruzubieta Paula , Craxi Antonio , Fracanzani Anna Ludovica , Grieco Antonio , Corradini Stefano Ginanni , Aghemo Alessio , Colombo Massimo , Soardo Giorgio , Bugianesi Elisabetta , Reeves Helen , Anstee Quentin M. , Fargion Silvia , Valenti Luca 
Published: June 2017

AbstractNonalcoholic fatty liver disease (NAFLD) represents an emerging cause of hepatocellular carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C > T MBOAT7/TMC4 variant predisposes to progressive NAFLD, but the impact on hepatic carcinogenesis is unknown. In Italian NAFLD patients, the rs641738 T allele was associated with NAFLD-HCC (OR 1.65, 1.08–2.55; n = 765), particularly in those without advanced fibrosis (p < 0.001). The risk T allele was linked to 3’-UTR variation in MBOAT7 and to reduced MBOAT7 expression in patients without severe fibrosis. The number of PNPLA3, TM6SF2, and MBOAT7 risk variants was associated with NAFLD-HCC independently of clinical factors (p < 0.001), but did not significantly improve their predictive accuracy. When combining data from an independent UK NAFLD cohort, in the overall cohort of non-cirrhotic patients (n = 913, 41 with HCC) the T allele remained associated with HCC (OR 2.10, 1.33–3.31). Finally, in a combined cohort of non-cirrhotic patients with chronic hepatitis C or alcoholic liver disease (n = 1121), the T allele was independently associated with HCC risk (OR 1.93, 1.07–3.58). In conclusion, the MBOAT7 rs641738 T allele is associated with reduced MBOAT7 expression and may predispose to HCC in patients without cirrhosis, suggesting it should be evaluated in future prospective studies aimed at stratifying NAFLD-HCC risk.
A Preliminary Study of a Spanish Graphic Novella Targeting Hearing Loss Prevention
Authors: Guiberson Mark , Wakefield Emily 
Published: June 2017

Purpose
This preliminary study developed a digital graphic novella targeting hearing protection beliefs of Spanish-speaking agricultural workers. Researchers used pretest–posttest interview surveys to establish if the novella had an immediate influence on the participants' beliefs about noise-induced hearing loss and usage of hearing protection devices.

Method
Researchers developed a digital graphic novella directed to increase knowledge about noise-induced hearing loss and increase the proper use of hearing protection devices. The novella was tailored to meet the specific linguistic and literacy needs of Spanish-speaking agricultural workers. Thirty-one Spanish-speaking farmworkers of Mexican nationality participated. This study included an interview survey with specific questions on noise-induced hearing loss, myths, and hearing protection device usage. A pretest–posttest design was applied to measure the graphic novella's immediate influence on workers.

Results
The posttest scores on Hearing Protection Beliefs statements were significantly better than pretest scores, with a large effect size observed.

Conclusion
Digital media may be an effective way to overcome language and literacy barriers with Spanish-speaking workers when providing health education and prevention efforts.
Aryloxide-Promoted Catalyst Turnover in Lewis Base Organo­catalysis
Authors: Hartley Will , O’Riordan Timothy , Smith Andrew 
Published: June 2017

This short review highlights select examples of enantioselective Lewis base promoted reactions that use tertiary amine (cinchona alkaloids, isothioureas, and DMAP/PPY derivatives) or NHC catalysts and employ aryloxide-promoted catalyst turnover from an acyl ammonium or azolium intermediate. This review focuses on the range of strategies that have been developed within this area, and discusses their evolution and context.1	Introduction2	Phenols as Additives To Promote Catalyst Turnover2.1	NHC Catalysis with α-Functionalised Aldehydes and Phenols2.2	Enantioselective Fluorination with Aryloxide-Promoted Catalyst Turnover3	In Situ Catalytic Generation Of Aryloxide3.1	Aryloxide-Promoted Turnover Generated from an Electrophilic Polyhalogenated Quinone: Overview3.2	Aryloxide-Promoted Catalyst Turnover Generated from an α-Aryl­oxyaldehyde or Aryl Ester Starting Material: Overview4	Summary and Outlook
A Randomized Trial of Foley Balloon Induction of Labor Trial in Multiparas (FIAT-M)
Authors: Kohari Katherine , Factor Stephanie , Rekawek Patricia , Miller Meredith , Smilen Brooke , Stone Joanne , Bianco Angela , Connolly Katherine 
Published: June 2017

Background The optimal method of labor induction is not known. It is important to determine the safest and efficient method to minimize the length of labor, hospital stay, cost, and adverse outcomes.
Objective This study aims to determine if induction of labor with simultaneous use of oxytocin and Foley balloon versus the sequential use of Foley balloon followed by oxytocin decreases the time to delivery in multiparous women.
Study Design We conducted a randomized controlled trial of multiparous women who presented for induction of labor at Mount Sinai from December 2013 to April 2016. Patients were admitted for induction with indications determined by their provider. Women with a nonanomalous, singleton fetus ≥ 24 weeks in vertex presentation with intact membranes were offered participation. Exclusion criteria included the history of uterine surgery, unexplained vaginal bleeding, latex allergy, or contraindication to vaginal delivery. Participants were randomized to either simultaneous (oxytocin and Foley balloon) or sequential (oxytocin after the expulsion of Foley balloon) induction group. The primary outcome was the time from induction to delivery. Secondary outcomes included mode of delivery, estimated blood loss (EBL), postpartum hemorrhage (PPH), chorioamnionitis, and composite neonatal outcome. Maternal and neonatal outcomes were collected via chart review. Analyses were done on an intention-to-treat basis.
Results A total of 142 patients were enrolled; 75 in the simultaneous and 67 in the sequential group. There were no differences in baseline characteristics in the two groups. There was no difference in median time to delivery between groups (10.7 vs. 10.6 hours, p = 0.44). There was no difference in the rate of cesarean delivery, EBL, PPH, chorioamnionitis, or composite neonatal outcome.
Conclusion Simultaneous use of oxytocin and Foley balloon for induction of labor does not decrease time to delivery in multiparas.
New Biguanides as Anti-Diabetic Agents Part I: Synthesis and Evaluation of 1-Substituted Biguanide Derivatives as Anti-Diabetic Agents of Type II Diabetes Insulin Resistant
Authors: Abbas Samir , Basyouni Wahid , El-Bayouk Khairy , Tohamy Wael , Aly Hanan , Arafa Azza , Soliman Mahmoud 
Published: June 2017

AbstractNew 1-substituted-biguanide hydrochloride salts were synthesized via reacting benzo[1,3-d]dioxol-5-amine, phenylhydrazine, N,N-dimethylhydrazinecarboxamide, benzohydrazide and 2-phenyl acetohydrazide with dicyandiamide in acidic medium. Structures of the obtained biguanide salts were characterized by spectroscopic tools. The synthesized compounds were screened for their anti-diabetic activity with standard metformin drug. Oral treatment of hyperglycemic rats with the synthesized biguanide derivatives significantly decreased the elevated blood glucose level. Additionally, anti-diabetic properties towards liver function enzyme activities (AST, ALT and ALP), lipids profiles (TC, TG and TL), lipid peroxide and nitrous oxide as well as histopathological studies relative to metformin hydrochloride were investigated and discussed.