bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of the influence of ethnicity on serology and clinical features in lupus
Authors: Morais S A , Isenberg D A 
Published: May 2016

Objective The objective of this study was to review the links between ethnicity, serology and clinical expression in systemic lupus erythematosus (SLE) in a single cohort that was followed over a 36-year period. Patients and methods Patients with SLE treated at the University College London Hospitals (UCLHs) between January 1978 and December 2013 formed the cohort. We assessed the demographic, clinical and serological data. Standard methods were used for laboratory testing. The Student t test and Mann–Whitney U test were used for the continuous variables; the Fisher’s exact test was used for the categorical variables. Results We studied 624 SLE patients: There were 571 women (91.5%), with a mean age at diagnosis of 29.0 ± 6.5 years; and 53 men (8.5%), with a mean age at diagnosis of 29.4 ± 15.3 years. Ethnically, 369 of the patients were European, 100 were Afro-Caribbean, 77 were East Asian, 56 were South Asian and 21 were of mixed ethnicity. The East Asian patients developed the disease at a younger age than the other ethnic groups ( p < 0.0001). The Afro-Caribbean patients were less frequently associated with the presence of rash and photosensitivity, and the non-European patients were more likely to have alopecia and renal involvement. The South Asian patients were significantly associated with musculoskeletal and neurological involvement, serositis, Sicca syndrome and hematological features. The Afro-Caribbean patients had the highest prevalence of anti-Smith, anti-RNP, anti-Ro and anti-La antibodies. Anti-IgG anticardiolipin (aCL) antibodies were significantly associated with the non-East Asian groups; and hypocomplementemia was common in the East Asians. Rash, alopecia, mouth ulcers, serositis, neurological, joint and renal involvement were significantly associated with the presence of anti-Smith and anti-RNP antibodies in the Afro-Caribbean group. We also observed an association of joint involvement and the presence of anti-Ro and anti-La antibodies in this group. Conclusions The East Asian patients developed their SLE disease at a younger age than the other ethnic groups. Cutaneous involvement was more frequent in those who were not Afro-Caribbean. Serositis, joint and neurological involvement were more frequently diagnosed in the South Asian patients. Anti-ENA antibodies were frequently associated with the Afro-Caribbean patients.
Patient factors associated with non-attendance at colonoscopy after a positive screening faecal occult blood test
Authors: Plumb Andrew A , Ghanouni Alex , Rainbow Sandra , Djedovic Natasha , Marshall Sarah , Stein Judith , Taylor Stuart A , Halligan Steve , Lyratzopoulos Georgios , von Wagner Christian 
Published: May 2016

Background Screening participants with abnormal faecal occult blood test results who do not attend further testing are at high risk of colorectal cancer, yet little is known about their reasons for non-attendance. Methods We conducted a medical record review of 170 patients from two English Bowel Cancer Screening Programme centres who had abnormal guaiac faecal occult blood test screening tests between November 2011 and April 2013 but did not undergo colonoscopy. Using information from patient records, we coded and categorized reasons for non-attendance. Results Of the 170 patients, 82 were eligible for review, of whom 66 had at least one recorded reason for lack of colonoscopy follow-up. Reasons fell into seven main categories: (i) other commitments, (ii) unwillingness to have the test, (iii) a feeling that the faecal occult blood test result was a false positive, (iv) another health issue taking priority, (v) failing to complete bowel preparation, (vi) practical barriers (e.g. lack of transport), and (vii) having had or planning colonoscopy elsewhere. The most common single reasons were unwillingness to have a colonoscopy and being away. Conclusions We identify a range of apparent reasons for colonoscopy non-attendance after a positive faecal occult blood test screening. Education regarding the interpretation of guaiac faecal occult blood test findings, offer of alternative confirmatory test options, and flexibility in the timing or location of subsequent testing might decrease non-attendance of diagnostic testing following positive faecal occult blood test.
Accelerated Brain DCE-MRI Using Iterative Reconstruction With Total Generalized Variation Penalty for Quantitative Pharmacokinetic Analysis: A Feasibility Study
Authors: Wang Chunhao , Yin Fang-Fang , Kirkpatrick John P. , Chang Zheng 
Published: May 2016

Purpose: To investigate the feasibility of using undersampled k-space data and an iterative image reconstruction method with total generalized variation penalty in the quantitative pharmacokinetic analysis for clinical brain dynamic contrast-enhanced magnetic resonance imaging. Methods: Eight brain dynamic contrast-enhanced magnetic resonance imaging scans were retrospectively studied. Two k-space sparse sampling strategies were designed to achieve a simulated image acquisition acceleration factor of 4. They are (1) a golden ratio–optimized 32-ray radial sampling profile and (2) a Cartesian-based random sampling profile with spatiotemporal-regularized sampling density constraints. The undersampled data were reconstructed to yield images using the investigated reconstruction technique. In quantitative pharmacokinetic analysis on a voxel-by-voxel basis, the rate constant Ktrans in the extended Tofts model and blood flow FB and blood volume VB from the 2-compartment exchange model were analyzed. Finally, the quantitative pharmacokinetic parameters calculated from the undersampled data were compared with the corresponding calculated values from the fully sampled data. To quantify each parameter’s accuracy calculated using the undersampled data, error in volume mean, total relative error, and cross-correlation were calculated. Results: The pharmacokinetic parameter maps generated from the undersampled data appeared comparable to the ones generated from the original full sampling data. Within the region of interest, most derived error in volume mean values in the region of interest was about 5% or lower, and the average error in volume mean of all parameter maps generated through either sampling strategy was about 3.54%. The average total relative error value of all parameter maps in region of interest was about 0.115, and the average cross-correlation of all parameter maps in region of interest was about 0.962. All investigated pharmacokinetic parameters had no significant differences between the result from original data and the reduced sampling data. Conclusion: With sparsely sampled k-space data in simulation of accelerated acquisition by a factor of 4, the investigated dynamic contrast-enhanced magnetic resonance imaging pharmacokinetic parameters can accurately estimate the total generalized variation-based iterative image reconstruction method for reliable clinical application.
Bony mallet finger injuries: assessment of stability with extension stress testing
Authors: Giddins G. E. 
Published: May 2016

Bony mallet injuries with a large dorsal fracture fragment may sublux giving a poor outcome. The hypothesis that was tested was that subluxation could be predicted by extension stress lateral radiographs. It was anticipated that the main distal fracture fragment would glide and be stable or pivot and be unstable. There were 32 bony mallet injuries with dorsal fracture fragments of >1/3 in 31 patients. There were three patterns shown on lateral extension stress radiographs: gliding, pivoting, and tilting – a combination of the former two. Defining stability as congruence or subluxation ⩽1 mm at final radiographs and instability as subluxation >1 mm, there was a very strong association with pivoting and subluxation, and gliding and congruence ( p < 0.001). Tilting gave mixed results. There was significant difference in the size of the fracture fragment in stable (mean 49%) and unstable injuries (54%) ( p = 0.044). Extension stress testing has a sensitivity of 89% and a specificity of 100%. Extension stress testing highlights that instability is not just a function of fracture fragment size and is a more reliable method of predicting subluxation than any previously described. Level of Evidence: V
Health Care Utilization and Direct Medical Costs of Tennis Elbow
Authors: Sanders Thomas L. , Maradit Kremers Hilal , Bryan Andrew J. , Ransom Jeanine E. , Morrey Bernard F. 
Published: May 2016

Background: Tennis elbow is commonly encountered by physicians, yet little is known about the cost of treating this condition. Hypothesis: The largest cost associated with treating tennis elbow is procedural intervention. Study Design: Descriptive epidemiology study. Level of Evidence: Level 4. Methods: This retrospective population-based study reviewed patients who were treated for new-onset tennis elbow between January 1, 2003 and December 31, 2012. All patients were followed up through their medical and administrative records to identify health care encounters and interventions for tennis elbow. Unit costs for each health service/procedure were adjusted to nationally representative unit costs in 2013 inflation-adjusted dollars. Results: In a cohort of 931 patients who had 2 or more clinical encounters for new-onset lateral epicondylosis during a 12-month period after initial diagnosis, 62% received a median of 3 physical therapy sessions (cost, $100/session) and 40% received a median of 1 steroid injection (cost, $82/injection). Only 4% of patients received surgical intervention with mean costs of $4000. The mean (median) total direct medical cost of services related to lateral epicondylosis for the entire cohort was $660 ($402) per patient over the 1-year period after diagnosis. Patients who continued to be treated conservatively between 6 and 12 months after diagnosis incurred relatively low median costs of $168 per patient. Conclusion: In this cohort, a second encounter with a physician for tennis elbow was a strong predictor of increased treatment cost due to a higher likelihood of specialist referral, use of physical therapy, or treatment with steroid injection. Clinical Relevance: The majority of direct medical spending on tennis elbow occurs within the first 6 months of treatment, and relatively little expense occurs between 6 and 12 months after diagnosis unless a patient undergoes surgical intervention.
Magnetic Resonance Imaging and Intra-articular Findings After Anterior Cruciate Ligament Injuries in Ice Hockey Versus Other Sports
Authors: Kluczynski Melissa A. , Kang Jeansol V. , Marzo John M. , Bisson Leslie J. 
Published: May 2016

Background: The prevalence of comorbid knee pathology has been examined for sports-related anterior cruciate ligament (ACL) injuries, but it has not been examined in ice hockey players. Purpose: To compare concomitant bone bruising, collateral ligament injuries, and intra-articular injuries in ACL injuries suffered during ice hockey versus other sports. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 20 patients with ACL injuries sustained during ice hockey were identified from a prospective registry, of which 95% were male and 90% had a contact mechanism of injury (MOI). Thirteen cases and 46 controls who sustained ACL injuries from ice hockey and other sports, respectively, were included. Inclusion criteria for cases and controls were male sex, contact MOI, no prior knee surgery, magnetic resonance imaging (MRI) within 6 weeks of injury, and surgery within 3 months of injury. Age, body mass index (BMI), MRI findings (bone bruising, medial and lateral collateral ligament [MCL, LCL] injuries), and arthroscopic findings (meniscus tears, chondral injuries) were compared for cases versus controls using t tests or exact chi-square tests. Results: Age (22.9 ± 8.8 vs 23.4 ± 10.4 years, P = .88) and BMI ≥25 kg/m2 (50% vs 65.9%, P = .66) did not differ between cases and controls. Cases had less lateral bone bruising (lateral femoral condyle: 54.6% vs 93%, P = .01; lateral tibial plateau: 72.7% vs 93%, P = .09) and no medial bone bruising (medial femoral condyle: 0% vs 7%, P = .06; medial tibial plateau: 0% vs 32.6%, P = .05) compared with controls. Cases had less frequent lateral meniscus tears than controls (23.1% vs 58.5%, P = .05). There were no significant differences in MCL (40% vs 31.2%, P = .77), LCL (0% vs 3.9%, P > .999), medial meniscus tears (7.7% vs 37%, P = .08), and chondral injuries (10% vs 9.4%, P > .999) for cases versus controls. Conclusion: Male ice hockey players with ACL injuries had less lateral femoral condyle and medial tibial plateau bone bruising compared with other sports injuries. They also had fewer lateral meniscus tears, and there was a trend toward fewer medial meniscus tears. These differences may reflect different MOIs, or the ability to dissipate energy, for contact ACL injuries that occur during ice hockey versus other sports.
De novoactin polymerization is required for model Hirano body formation inDictyostelium
Authors: Dong Yun , Shahid-Salles Sonbol , Sherling Dan , Fechheimer Nathan , Iyer Nathan , Wells Lance , Fechheimer Marcus , Furukawa Ruth 
Published: May 2016

ABSTRACTHirano bodies are eosinophilic, actin-rich inclusions found in autopsied brains in numerous neurodegenerative diseases. The mechanism of Hirano body formation is unknown. Mass spectrometry analysis was performed to identify proteins from partially purified model Hirano bodies from Dictyostelium. This analysis identified proteins primarily belonging to ribosomes, proteasomes, mitochondria and cytoskeleton. Profilin, Arp/2/3 and WASH identified by mass spectrometry were found to colocalise with model Hirano bodies. Due to their roles in actin regulation, we selected these proteins for further investigation. Inhibition of the Arp2/3 complex by CK666 prevented formation of model Hirano bodies. Since Arp2/3 activation occurs via the WASH or WAVE complex, we next investigated how these proteins affect Hirano body formation. Whereas model Hirano bodies could form in WASH-deficient cells, they failed to form in cells lacking HSPC300, a member of the WAVE complex. We identified other proteins required for Hirano body formation that include profilin and VASP, an actin nucleation factor. In the case of VASP, both its G- and F-actin binding domains were required for model Hirano body formation. Collectively, our results indicate that de novo actin polymerization is required to form model Hirano bodies.
System of Labor Activities with the Use of ICT in Occupational Standards for Teachers (Module �Subject learning. Technology�)
Authors: ���������  , Nekrasova G. , ��������  , Novikova Natalya 
Published: May 2016

The article considers relevant issues of the implementation of occupational standards for teachers. It analyses teacher�s activity in the area of information
and communication technologies (ICT). By the example of live pedagogical situations, the article shows that ICT play a signifi cant role in organizing
of education process and fundamentally change the nature of teacher�s professional activity with the development of Information-oriented Society.
Occupational standards for teachers were examined and analyzed for the purpose of detecting the place of labor activities in the area of ICT at the level
of generalized fundamental labor functions. Technology teacher activities went through an in-depth analysis and changes in professional task of technology
teachers in educational information environment were described. For the fi rst time the grounds and the list of labor activities with the use of ICT
in occupational standards for teachers (Module �Subject learning. Technology�) are given.
Perolehan Tio2 Dari Iron Ore Mengandung Titanium Melalui Proses Reduksi Karbon Dan Pelarutan Asam
Authors: Rayhana Elda , Manaf Azwar 
Published: May 2016

<span>REDUCTION AND LEACHING PROCESSES<span><strong>. </strong><span>Indonesia has a large source of iron ore <span>which is quite tempting for the purposes of exploitation in form of raw materials as well as <span>for the production of pig iron. However, not all sources of iron ore are proved useful since <span>not only because the present of deposit is scattere dinamounts of less significant but also <span>because it contains element of tin oxide compounds with iron like ilmenite or FeTiO<span>3<span>. <span>However,ilmenite can actually be used as a source of titanium metal which is much more <span>valuable than Fe it self. In order to recover the Ti from their respective compound it is <span>required the release of strong bonds between the atoms in the compound. This paper reports <span>the recovery of Ti oxide of ilmenite containing iron ore which was obtained through a <span>combination of carbon reduction and acid leaching processes. Carbon reduction of iron ore <span>was carried out through mechanical milling between iron ore and carbon with a ratio of 1:1. <span>This was successively followed by a sintering at a temperature of 1000 <span>o<span>C employing a <span>heating rate of 10 ° C/min for 0-3 hours. The reduction process has resulted in the <span>formation of 27.83wt% TiO2. In order to improve the recovery level of TiO<span>2<span>, further <span>reduction process was conducted through an HCl leaching. This successive stage produced <span>fine powders in the form of deposits. Based on our quantitative analysis, the recovery of <span>TiO<span>2 <span>increased to a level of 73.73%.</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span></span></span></span></span></span></span>
Effect of Annealing Temperature On Iron Doped Titanium Dioxide Thin Films Prepared By Spin Coating Technique
Authors: Effendi Mukhtar , B Bilalodin 
Published: May 2016

<span>Iron (Fe) doped titanium dioxide (TiO<span>2<span>) thin films have been successfully deposited by <span>using spin coating technique. X-ray diffraction (XRD) and Scanning Electron Microscope <span>(SEM) were employed to characterize the microstructure and crystallite morphology of the <span>films. It was indicated that the rutile crystal orientation appears due to increasing annealing <span>temperature of the thin films. Furthermore, increasing annealing temperature of the thin <span>films yielded an increasing of porosity value which is related to the application on gas <span>sensor films.</span></span></span></span></span></span><br /></span></span></span>
Analisa Receiver Function Teleseismic untuk Mendeteksi Moho pada Stasiun Bkb Data Meramex
Authors: Amukti Rian , Suryanto Wiwit 
Published: May 2016

<span>It has been done a research to determine internal earth using receiver function teleseismic analysis <span>method. This method have been done by using MERAMEX (MErapi Amphibious Experiment) data from <span>broadband seismometer BKB. Event of teleseismic is chosen from Honshu Japan with radius 30<span>o <span>and <span>magnitude 7.2. This research begun by analysing radial and vertical characteristic of teleseismic event<br /><span>and using bandpass filter with range 0.003 Hz – 0.5 Hz. Then Iteractive Deconvolution is used to get <span>velocity model. The result of this model shows crustal model that has 4 Km thick upper crust, a 26 Km <span>thick lower crust and 10 Km thick Moho transition zone, with velocity increasing gradually.</span></span></span></span></span></span><br /></span></span></span>
Zielklärung und Zielerreichung im Coaching
Authors: Wastian Monika , Poetschki Janina 
Published: May 2016

Zusammenfassung
In einer qualitativen Untersuchung wurden Coaching-Prozesse mit Hilfe einer visuell gestützten Interview-Methode mit 43 Coachs bzw. 19 Klienten rekonstruiert, um unter anderem den Prozess der Zielklärung und Zielerreichung zu explorieren. Dabei gingen wir den folgenden Fragen nach: a) Wie erfolgen die Zielklärung sowie die Steuerung der Zielfortschritte im Coaching aus der Sicht von Coaches bzw. Coaching-Klienten und inwieweit werden dabei die Wirkzusammenhänge der Zielsetzungstheorie berücksichtigt? b) Wann im Verlauf des Coachings werden die Ziele zwischen den Beteiligten thematisiert? c) Gibt es typische Muster des Zielklärungs- bzw. Zielerreichungsprozesses?
Wie die Ergebnisse zeigen, werden Coaching-Ziele während des gesamten Coaching-Prozesses und teilweise sogar darüber hinaus im Rahmen von Follow-ups thematisiert, doch werden sie mehrheitlich nicht spezifisch, messbar und terminiert geklärt. Die Sichtweisen von Coachs und Coachees klaffen diesbezüglich deutlich auseinander. Dabei nennen Coachees spezifische und messbare Ziele als wichtigsten Verbesserungswunsch. Als typischste Muster ließen sich die SMARTe Zielklärung zu Beginn des Coachings und die Zielklärung als „Suchlauf“ über den Coaching-Prozess hinweg identifizieren.
Implikationen für die Coaching-Forschung und Praxis werden diskutiert und Handlungsempfehlungen gegeben, wie Coaching-Beteiligte zur Qualität und zum Erfolg ihrer Coachings beitragen können.
Local memories: Conflict and lived experience in the Spanish Civil War
Authors: Sanz Sabido Ruth 
Published: May 2016

Abstract
The winners of any conflict often try to impose their views on the defeated. Through official and unofficial mechanisms, most of which operate under the aegis of the state and other agents that work on its behalf, the voices of the defeated are silenced. One important counter-mechanism that is available, the one that may serve to resist the imposition of the victors’ History, is frequently found in the collection, analysis and publication of oral testimonies, which give expression to, and magnify, silenced and oppressed memories. Orality therefore provides us with a window into past events or, rather, with multiple windows that allow us to see and take account of the myriad histories of which the past is actually composed, according not to the state-imposed version, but to the ways in which people remember it. Through an ethnographic study of local memories in one southern Spanish village, this article examines some of the ways in which the Spanish Civil War is remembered, focusing particularly on the lived experience of repression and hunger, and the memories of ideological clashes, class struggles and conflicts over land ownership.
Creative destruction: Screen production research, theory and affect
Authors: Berkeley Leo , Wood Martin , Glisovic Smiljana 
Published: May 2016

Abstract
The documentary film 600 Mills was explicitly funded and produced as an academic research project, designed to investigate, through cinematic means, the decline of the textile industry in the Melbourne suburb of Brunswick. Drawing on the work of Thrift, Deleuze and Guattari, Massumi and others, it is argued that the film production process uses ‘affect’ as a form of sensory knowing that can engage with relevant theory and be used to conceive of film-making as a valid form of academic research. This article discusses the approach taken by three film-maker researchers in making a film that, instead of using the medium to convey information or communicate research findings gathered through other means, seeks to use the creative possibilities of film production to convey knowledge about a complex human, social and historical process.
The spaces between: Children, teachers, researchers, artists
Authors: Thompson Christine Marmé 
Published: May 2016

Abstract
Direct engagement with children, teachers and the curriculum that brings them together in pedagogical relationships figure prominently in my work with beginning teachers and researchers. A dialogical approach to teaching, celebrating the contingencies of each class and each situation, leads to a vital and constantly challenging engagement with the process of educating as reciprocal and open-ended. Grounded in philosophies of reciprocity and relationship, this way of being in the university respects the rhizomatic nature of knowing and becoming, eschewing the overly determined and stratified spaces of pre-ordained and standardized curriculum in favour of the emergent and unpredictable.