bluuebunny/crossref_metadata_2025_split huggingface dataset:
When do investment banks use IPO price support?
Authors: Fjesme Sturla Lyngnes 
Published: January 2018

AbstractPractitioners, regulators, and the financial media argue that underwriters tie initial public offering (IPO) allocations to investor post‐listing buying of the issuer shares in a process labelled price support. Arguably, this excess demand boosts post‐listing returns which underwriters trade quid pro quo with investor stock‐trading commission payments. In this paper, I investigate unique data from the Oslo Stock Exchange (OSE) including investor stock‐trading commissions, IPO allocations, and post‐listing trading. I document that investors who provide high returns to underwriters before IPOs benefit from price support through increased returns in IPOs. I conclude that price support is used when investors share boosted returns with underwriters.
Suspected case of hypersplenism as a cause of anaemia, thrombocytopenia and leucopenia in a Miniature Horse gelding
Authors: Ruby R. E. , Wong D. M. , Sponseller B. A. , Yaeger M. 
Published: January 2018

SummaryA 23‐year‐old Miniature Horse gelding was presented to the Lloyd Veterinary Medical Center with a 3‐week history of decreased appetite, lethargy and mild intermittent colic. A complete blood count revealed leucopenia, characterised by neutropenia and lymphopenia, as well as anaemia, thrombocytopenia and hyperproteinaemia whereas hypertriglyceridaemia was noted on serum biochemistry profile. Bone marrow evaluation was nondiagnostic and the horse was negative for antiplatelet antibody testing, Coombs test, equine infectious anaemia virus andAnaplasma phagocytophilum. The horse was hospitalised for 36 days and received supportive care, antibiotics, corticosteroids, dextrose‐containing fluids and a whole blood transfusion. Following initial improvement and stabilisation, the horse became severely anaemic and acutely recumbent on Day 36 and was subjected to euthanasia. Post‐mortem examination provided a diagnosis of hypersplenism with a markedly enlarged spleen along with histiocytic phagocytosis of erythrocytes and platelets. Examination of bone marrow showed appropriate erythroid hyperplasia and no evidence of myelopthisis or neoplasia. This report describes the first presumptive case of primary hypersplenism in an equid as a cause of pancytopenia.
Comprehensive circRNA expression profile and construction of circRNA‐associated ceRNA network in fur skin
Authors: Zhu Zhiwei , Li Yuan , Liu Wenyan , He Junping , Zhang Lihuan , Li Huifeng , Li Pengfei , Lv Lihua 
Published: January 2018

AbstractCircular RNA (circRNA), a class of non‐coding RNAs, is a new group of RNAs that are related to tumorigenesis. The role of circRNAs in various diseases has been already highlighted. However, the expression levels and functions of circRNAs related to the melanocytes in the skin are poorly understood. RNA sequence was performed to analyse the expression profiles of circRNAs in black fur skin and white fur skin during different differentiation stages and investigate the relevant metabolism mechanisms. Differentially expressed circRNAs were detected using empirical Bayes sequencing (EBSeq) and then verified through the quantitative real‐time PCR method. The EQSeq analysis of circRNAs identified 11 downregulated and 32 upregulated circRNAs in the embryo of black fur skin and white fur skin, as well as 21 downregulated and 17 upregulated circRNA in the postnatal stage. A circRNA–microRNA (miRNA)–messenger RNA (mRNA) network was established to predict the circRNA targets. Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were applied to enrich the mRNA data further. Results showed that the specific mRNAs mainly involved in the transcription‐related GOs, especially GO:0042802, GO:0005080 and GO:0032403, demonstrate their specific actions in transcriptional regulation. In the circRNA–miRNA–mRNA network, the most enriched GO terms of the mRNAs were pigmentation, protein autophosphorylation and protein complex. Therefore, the circRNA–miRNA–mRNA pathway may reveal novel mechanisms for pigmentation, and circRNAs may serve as candidates in pigmentation.
Higher precipitation strengthens the microbial interactions in semi‐arid grassland soils
Authors: Wang Shang , Wang Xiaobo , Han Xingguo , Deng Ye 
Published: January 2018

AbstractAimGrowing attention has been focused on the changes in the structure and diversity of microbial communities under altered precipitation pattern, but little is known about how this factor impacts microbial interactions. Our aim was to elucidate the variations of microbial interactions in semi‐arid grassland soils and determine the key factor in regulating microbial assemblies in water‐limited areas.LocationA c. 3,700 km transect across three habitats (desert, desert grassland and typical grassland) in Northern China.Time periodJuly and August 2012.Major taxa studiedTotal bacteria and archaea.MethodThe random matrix theory (RMT)‐based network inference approach was used to construct species interaction networks. The relationships between microbial network topology and environmental variables were examined by Mantel and partial Mantel tests.ResultsAt the regional scale (across habitats), mean annual precipitation was the most important factor constraining the network structure, whereas at the local scale (within a habitat), soil conditions and plant parameters became more important, but their relative effects differed among habitats. In particular, no correlation was detected between the desert network and any environmental factors. The number of central species increased substantially in desert grassland and typical grassland networks in comparison to those in the desert network. Inter‐ and intra‐module connections, particularly negative connections, also increased in the two grassland habitats.Main conclusionsMicrobial networks become more complex as precipitation increases. A simple network structure (no connectors between modules, more sparsely distributed species and lower competitive links) and less association with environmental factors in the desert network indicate that microbial communities in extremely dry ecosystems are unstable and vulnerable; that is, future climate change will greatly influence microbial interactions in these extremely dry areas. Overall, our findings provide new insight into the way in which microbes respond to changing precipitation patterns by regulating their interactions in water‐limited ecosystems.
Internet medievalism and the White Middle Ages
Authors: Elliott Andrew B.R. 
Published: January 2018

AbstractThe Middle Ages, and ideas about modern culture drawn from or rooted in the medieval period, have found themselves recurring with alarming frequency within recent political discourse. From President Bush's crusade rhetoric surrounding the War on Terror to the Far Right's location of White nationalism within an ongoing framework of medieval nation‐founding, the past has increasingly been used in the service of the present. In their more egregious forms—such as the rise of White supremacist movements in Europe, the USA, and Australia and their amalgamation into mainstream political discourse—the use of medieval national and cultural memories has led to a whitewashing of the medieval past. This article argues that these instances of medievalism are not simply inaccuracies but come about through a recirculation of vague ideas about the Middle Ages through online in‐groups. Consequently, such political uses of the medieval past are often what have been termed “banal” medievalisms in the sense that they are not always intended as deliberate references to history by useful appropriations in the service of the present.
Effect of root canal irrigation protocols on the dislocation resistance of mineral trioxide aggregate‐based materials: A systematic review of laboratory studies
Authors: Neelakantan P. , Ahmed H. M. A. , Wong M. C. M. , Matinlinna J. P. , Cheung G. S. P. 
Published: January 2018

AbstractThe aim of this systematic review was to address the question: Do different irrigating protocols have an impact on the dislocation resistance of mineral trioxide aggregate (MTA)‐based materials? The review was performed using a well‐defined search strategy in three databases (PubMed, Scopus, Web of Science) to include laboratory studies performed between January 1995 and May 2017, in accordance with PRISMA guidelines. Two reviewers analysed the papers, assessed the risk of bias and extracted data on teeth used, sample size, size of root canal preparation, type of MTA‐based material, irrigants, canal filling method, storage method and duration, region of roots and the parameters of push‐out testing (slice thickness, plunger dimensions and plunger loading direction), the main results and dislocation resistance values (in MPa). From 255 studies, 27 were included for full‐text analysis. Eight papers that met the inclusion criteria were included in this review. There was a wide variation in dislocation resistance due to differences in irrigation sequence, time and concentration of irrigants, storage method and duration, and the parameters of push‐out bond strength testing. A meta‐analysis was not done but qualitative synthesis of the included studies was performed. No definitive conclusion could be drawn to evaluate the effect of irrigation protocols on dislocation resistance of MTA‐based materials. Recommendations have been provided for standardized testing methods and reporting of future studies, so as to obtain clinically relevant information and to understand the effects of irrigating protocols on root canal sealers and their interactions with the dentine walls of root canals.
Genotypic diversity of bacteria and yeasts isolated from Tibetan kefir
Authors: Gao Wei , Zhang Lanwei 
Published: January 2018

SummaryIn this study, we have investigated the intraspecies genotypic diversity of bacteria and yeasts isolated from Tibetan kefir via the (GTG)5‐REP‐PCR technology. According to the cluster analysis of generated fingerprints, forty‐nine bacterial isolates were grouped into nine clusters and formed thirteen genotypes, and twenty‐two yeast isolates were grouped into two clusters and formed two genotypes. It's worth noting that isolates of Lactobacillus kefiranofaciens, Streptococcus thermophilus, Lactobacillus kefiri and Lactobacillus paracasei exhibited the intraspecies genotypic diversity, whereas isolates of Saccharomyces cerevisiae and Kazachstania unispora did not exhibit. These results confirmed that bacterial isolates possessed higher level of intraspecies genotypic diversity than yeast isolates studied in this research. These findings revealed that (GTG)5‐REP‐PCR was an efficient and sensitive molecular typing tool for revealing the intraspecies genotypic diversity among the bacterial isolates originated from Tibetan kefir.
‘To be treated as a human’: Using co‐production to explore experts by experience involvement in mental health nursing education – The COMMUNE project
Authors: Horgan Aine , Manning Fionnuala , Bocking Julia , Happell Brenda , Lahti Mari , Doody Rory , Griffin Martha , Bradley Stephen K. , Russell Siobhan , Bjornsson Einar , O'Donovan Moira , MacGabhann Liam , Savage Eileen , Pulli Jarmo , Goodwin John , van der Vaart Kornelis Jan , O'Sullivan Hazel , Dorrity Claire , Ellila Heikki , Allon Jerry , Hals Elisabeth , Sitvast Jan , Granerud Arild , Biering Pall 
Published: January 2018

AbstractIncreasingly, experts as deemed by personal experience or mental health service use, are involved in the education of nurses; however, accompanying research is limited and focuses primarily on opinions of nurse educators and students. The aim of this study was to develop an understanding of the potential contribution to mental health nursing education by those with experience of mental health service use. The research was part of the international COMMUNE (Co‐production of Mental Health Nursing Education) project, established to develop and evaluate co‐produced mental health content for undergraduate nursing students. A qualitative descriptive design was adopted with data collected through focus group interviews in seven sites across Europe and Australia. Experts by experience (people with experience of distress, service use, and recovery) co‐produced the project in partnership with nursing academics. Co‐production enriched the process of data collection and facilitated the analysis of data from multiple perspectives. Two themes are presented in this paper. The first focuses on how experts by experience can enhance students’ understanding of recovery by seeing the strengths inherent in the ‘human’ behind the diagnostic label. The second highlights the importance of communication and self‐reflection on personal values, where students can explore their own thoughts and feelings about mental distress alongside those with lived experience. Interacting with experts by experience in the classroom can assist in challenging stigmatizing attitudes prior to nursing placements. These findings can be used to inform international nursing curricula by increasing the focus on nursing skills valued by those who use the services.
Conceptualising the link between information systems and resilience: A developing country field study
Authors: Heeks Richard , Ospina Angelica V. 
Published: January 2018

AbstractResilience—the ability of systems to cope with external shocks and trends—is a topic of increasing interest to research and practice. That growing interest is reflected within information systems (IS), but a structured review of IS literature shows a number of knowledge gaps around the conceptual and empirical application of resilience. This paper investigates what the subdiscipline of information and communication technologies for development (ICT4D) can contribute; finding that it offers the IS discipline fresh insights that can be built into a new framework of resilience, and an arena within which this new framework can appropriately be field tested. Application of the resilience framework was undertaken through interviews and a survey in an urban community in Costa Rica; benchmarking both community resilience and “e‐resilience” (understood here as the contribution of ICTs to community resilience), and developing from these a set of action priorities. The paper reflects on what can be learned generally from this conceptualisation and operationalisation of resilience. It also reflects on what ICTs contribute to resilience in developing countries and on what this ICT4D‐based research specifically contributes to the identified IS knowledge gaps. This includes identification of a future research agenda on information systems and resilience.
Impact of information incongruity and authors group membership on assimilation and accommodation
Authors: Moskaliuk J. , Matschke C. 
Published: January 2018

AbstractLearning is a complex process that can be differentiated into assimilation and accommodation. The Internet enables both types of learning through collaboration. There is, however, little research investigating the specific impact of social and information incongruity on assimilation and accommodation. The current research investigates how the information incongruity between prior knowledge and new information on the one hand and the social incongruity caused by the group membership of an information source on the other hand stimulates assimilation and accommodation specifically. It is predicted that medium incongruity stimulates assimilation and accommodation more strongly than low incongruity. Moreover, concerning social incongruity, ingroup information should specifically increase assimilation more strongly than outgroup information. A laboratory study with a 2 × 2 design using between‐subject factors information incongruity (low vs. medium) and social incongruity (ingroup vs. outgroup information) was conducted wherein participants worked on an ostensibly collaborative wiki. It was found that medium information incongruity stimulated stronger structuring of knowledge (i.e., internal accommodation) and stronger integration of new information into a wiki text (i.e., external accommodation) than low incongruity. As expected, ingroup information increased the acquisition of factual knowledge (i.e., assimilation) more strongly than outgroup information.
Molecular evidence and clinical importance of β‐arrestins expression in patients with acromegaly
Authors: Coelho Maria Caroline Alves , Vasquez Marina Lipkin , Wildemberg Luiz Eduardo , Vázquez‐Borrego Mari C. , Bitana Luciana , Camacho Aline Helen da Silva , Silva Débora , Ogino Liana Lumi , Ventura Nina , Chimelli Leila , Luque Raul M. , Kasuki Leandro , Gadelha Mônica R. 
Published: January 2018

Abstractβ‐arrestins seem to have a role in endocytosis and desensitization of somatostatin receptor subtype 2 (sst2) and could be associated with the responsiveness to somatostatin receptor ligands (SRL) in patients with acromegaly. To investigate the in vivo correlation between β‐arrestins 1 and 2 with sst2, sst5 and dopamine receptor subtype 2 (D2) expressions, and the association of β‐arrestins with response to first‐generation SRL and invasiveness in somatotropinomas. β‐arrestins 1 and 2, sst2, sst5 and D2 mRNA expressions were evaluated by quantitative real‐time RT‐PCR on tumoral tissue of 96 patients. Moreover, sst2 and sst5 protein expressions were also evaluated in 40 somatotropinomas by immunohistochemistry. Response to SRL, defined as GH <1 μg/l and normal IGF‐I levels, was assessed in 40 patients. The Knosp‐Steiner criteria were used to define invasiveness. Median β‐arrestin 1, β‐arrestin 2, sst2, sst5 and D2 mRNA copy numbers were 478; 9375; 731; 156; and 3989, respectively. There was a positive correlation between β‐arrestins 1 and 2 (R = 0.444, P < 0.001). However, no correlation between β‐arrestins and sst2, sst5 (mRNA and protein levels) or D2 was found. No association was found between β‐arrestins expression and SRL responsiveness or tumour invasiveness. Although previous data suggest a putative correlation between β‐arrestins and sst2, our data clearly indicated that no association existed between β‐arrestins and sst2, sst5 or D2 expression, nor with response to SRL or tumour invasiveness. Therefore, further studies are required to clarify whether β‐arrestins have a role in the response to treatment with SRL in acromegaly.
Wogonoside induces depalmitoylation and translocation of PLSCR1 and N‐RAS in primary acute myeloid leukaemia cells
Authors: Li Hui , Yu Xiaoxuan , Liu Xiao , Hu Po , Shen Le , Zhou Yuxin , Zhu Yu , Li Zhiyu , Hui Hui , Guo Qinglong , Xu Jingyan 
Published: January 2018

AbstractAcute myeloid leukaemia (AML) comprises a range of disparate genetic subtypes, involving complex gene mutations and specific molecular alterations. Post‐translational modifications of specific proteins influence their translocation, stability, aggregation and even leading disease progression. Therapies that target to post‐translational modification of specific proteins in cancer cells represent a novel treatment strategy. Non‐homogenous subcellular distribution of PLSCR1 is involved in the primary AML cell differentiation. However, the nuclear translocation mechanism of PLSCR1 remains poorly understood. Here, we leveraged the observation that nuclear translocation of PLSCR1 could be induced during wogonoside treatment in some primary AML cells, despite their genetic heterogeneity that contributed to the depalmitoylation of PLSCR1 via acyl protein thioesterase 1 (APT‐1), an enzyme catalysing protein depalmitoylation. Besides, we found a similar phenomenon on another AML‐related protein, N‐RAS. Wogonoside inhibited the palmitoylation of small GTPase N‐RAS and enhanced its trafficking into Golgi complex, leading to the inactivation of N‐RAS/RAF1 pathway in some primary AML cells. Taken together, our findings provide new insight into the mechanism of wogonoside‐induced nuclear translocation of PLSCR1 and illuminate the influence of N‐RAS depalmitoylation on its Golgi trafficking and RAF1 signalling inactivation in AML.
MicroRNA‐99a is a novel regulator of KDM6B‐mediated osteogenic differentiation of BMSCs
Authors: Tang Yin , Zhang Lan , Tu Tianchi , Li Yijia , Murray Dana , Tu Qisheng , Chen Jake Jinkun 
Published: January 2018

AbstractSkeletal tissue originates from mesenchymal stem cells (MSCs) with differentiation potential into the osteoblast lineage regulated by essential transcriptional and post‐transcriptional mechanisms. Recently, miRNAs and histone modifications have been identified as novel key regulators of osteogenic differentiation of MSCs. Here, we identified miR‐99a and its target lysine (K)‐specific demethylase 6B (KDM6B) gene as novel modulators of osteogenic differentiation of bone mesenchymal stem cells (BMSCs). Microarray profiling and further validation by quantitative real‐time RT‐PCR revealed that miR‐99a was up‐regulated during osteoblastic differentiation of BMSCs, and decreased in differentiated osteoblasts. Transfection of miR‐99a mimics inhibited osteoblastic commitment and differentiation of BMSCs, whereas inhibition of miR‐99a by inhibitors enhances these processes. KDM6B was determined as one of important targets of miR‐99a, which was further confirmed by luciferase assay of 3′‐UTR of KDM6B. Moreover, HOX gene level decreased after transfection of miR‐99a mimics in BMSCs, which indicated that KDM6B is a bona fide target of miR‐99a. Furthermore, in a model of in vivo bone regeneration, osteoblast‐specific gain‐ and loss‐of‐function experiments performed using cranial bone defects revealed that miR‐99a mimics‐transfected BMSCs reduced bone formation, and conversely, miR‐99a inhibitors‐transfected BMSCs increased in vivo bone formation. Tissue‐specific inhibition of miR‐99a may be a potential novel therapeutic approach for enhancing BMSCs‐based bone formation and regeneration.
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma
Authors: Wang Xiaoxia , Xu Wujian , Zhan Ping , Xu Tianxiang , Jin Jiajia , Miu Yingying , Zhou Zejun , Zhu Qingqing , Wan Bing , Xi Guangmin , Ye Liang , Liu Yafang , Gao Jianwei , Li Huijuan , Lv Tangfeng , Song Yong 
Published: January 2018

AbstractThis study aimed to evaluate the biological role of geranylgeranyl diphosphate synthase (GGPPS) in the progression of lung adenocarcinoma. GGPPS expression was detected in lung adenocarcinoma tissues by qRT‐PCR, tissue microarray (TMA) and western blotting. The relationships between GGPPS expression and the clinicopathological characteristics and prognosis of lung adenocarcinoma patients were assessed. GGPPS was down‐regulated in SPCA‐1, PC9 and A549 cells using siRNA and up‐regulated in A549 cells using an adenoviral vector. The biological roles of GGPPS in cell proliferation, apoptosis, migration and invasion were determined by MTT and colony formation assays, flow cytometry, and transwell and wound‐healing assays, respectively. In addition, the regulatory roles of GGPPS on the expression of several epithelial‐mesenchymal transition (EMT) markers were determined. Furthermore, the Rac1/Cdc42 prenylation was detected after knockdown of GGPPS in SPCA‐1 and PC9 cells. GGPPS expression was significantly increased in lung adenocarcinoma tissues compared to that in adjacent normal tissues. Overexpression of GGPPS was correlated with large tumours, high TNM stage, lymph node metastasis and poor prognosis in patients. Knockdown of GGPPS inhibited the migration and invasion of lung adenocarcinoma cells, but did not affect cell proliferation and apoptosis. Meanwhile, GGPPS inhibition significantly increased the expression of E‐cadherin and reduced the expression of N‐cadherin and vimentin in lung adenocarcinoma cells. In addition, the Rac1/Cdc42 geranylgeranylation was reduced by GGPPS knockdown. Overexpression of GGPPS correlates with poor prognosis of lung adenocarcinoma and contributes to metastasis through regulating EMT.