bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of patello-femoral arthrosis to the outcome of unicompartmental arthroplasty
Authors: Tüzüner Tolga , Uygur Ayşe Esin , Çirçi Esra , Eren Murat , Demirci Ziya 
Published: March 2017

Purpose: Unicompartmental knee arthroplasty is developed for the treatment of unicompartment arthrosis. Participation of multi compartments to the disease and patello-femoral arthrosis classically form a contraindication for this surgery. Different opinions were reported in literature on this subject. In this study, the effects of the presence of patello-femoral arthrosis on post-operative clinical and functional outcomes and revision process were investigated. Method: Pre-operative magnetic resonance (MR) images of 52 patients undergone medial unicompartmental knee arthroplasty between the years of 2011-2016 who completed minimum 6 months of follow-up period were evaluated. According to the presence of patello-femoral arthrosis, patients were classified into groups as non-arthrosis, grade 1-2 and grade 3-4. Statistical comparison were performed on knee society score (KSS), functional knee society score (fKSS), Oxford knee score (OKS), visual analog scale (VAS) score and post-operative joint range of motion (ROM) results. Results: 24 of 52 patients had no patello-femoral arthrosis. 13 patients were diagnosed with grade 1-2 and 15 patients were diagnosed with grade 3-4 patello-femoral arthrosis. No statistically significant difference was observed in patello-femoral arthrosis groups in average post-operative KSS, fKSS, OKS, VAS values. No revision proceeding was demonstrated in regression analysis. Conclusion: The results obtained from this study demonstrated that patello-femoral arthrosis has no effect on clinical and functional results. Yet, it is also considered that there is no factor to affect the implant survival rate. Having that said, when the number of patients and relatively short follow-up periods are considered, it is our opinion that new studies are required in this matter. [Figure: see text]
TheREE-and HFSE-bearing phases in the Itatiaia alkaline complex (Brazil) and geochemical evolution of feldspar-rich felsic melts
Authors: Melluso Leone , Guarino Vincenza , Lustrino Michele , Morra Vincenzo , de' Gennaro Roberto 
Published: March 2017

AbstractThe Late Cretaceous Itatiaia complex is made up of nepheline syenite grading to peralkaline varieties, quartz syenite and granite, emplaced in the metamorphic rocks of the Serra do Mar, SE Brazil. The nepheline syenites are characterized by assemblages with alkali feldspar, nepheline, Fe-Ti oxides, clinopyroxene, amphibole, apatite and titanite, while the peralkaline nepheline syenites have F-disilicates (rinkite, wöhlerite, hiortdahlite, låvenite), britholite and pyrophanite as the accessory phases. The silica-oversaturated rocks have alkali feldspar, plagioclase, quartz, amphibole, clinopyroxene and Fe-Ti oxides; the chevkinite-group minerals are the featured accessory phases and are found with allanite, fluorapatite, fluorite, zircon, thorite, yttrialite, zirconolite, pyrochlore and yttrocolumbite. The major- and trace-element composition of the Itatiaia rocks have variations linked to the amount of accessory phases, have smooth, enriched chondritenormalized rare-earth element (REE) distribution patterns in the least-evolved nepheline syenites and convex patterns in the most-evolved nepheline syenites. TheREEdistribution patterns of the quartz syenites and granites show a typical pattern caused by fractional crystallization of feldspar and amphibole, in an environment characterized by relatively high oxygen fugacity (>NiNiO buffer) and high concentrations of H2O and F, supporting the crystallization of hydrous phases, fluorite and F-disilicates. The removal of small amounts of titanite in the transition from the least-evolved to the most-evolved nepheline syenites stems from petrogenetic models involvingREE, and is shown to be a common feature of the magmatic evolution of many other syenitic/ trachytic/ phonolitic complexes of the Serra do Mar and elsewhere.
Alternative donors for allogeneic hematopoietic stem cell transplantation in poor-risk AML in CR1
Authors: Versluis Jurjen , Labopin Myriam , Ruggeri Annalisa , Socie Gerard , Wu Depei , Volin Liisa , Blaise Didier , Milpied Noel , Craddock Charles , Yakoub-Agha Ibrahim , Maertens Johan , Ljungman Per , Huynh Anne , Michallet Mauricette , Deconinck Eric , Chevallier Patrice , Passweg Jakob , Ciceri Fabio , Mohty Mohamad , Cornelissen Jan J. , Nagler Arnon 
Published: March 2017

Key Points
The preferred donor for patients with poor-risk AML in CR1 proceeding to alloHSCT include MRD or 10/10 MUD. Alternative donors are 9/10 MUD, UCB grafts, and especially haplo, but sufficient numbers and follow-up to define a hierarchy are lacking.
Translational research in pediatric pulmonary disease, 2017
Authors: Rubin Bruce K. 
Published: March 2017

AbstractAs readers of this journal know, translational research is the application of basic science findings to improve clinical care; a process that was once called “bench‐to‐bedside” research. In my field of pediatric pulmonary disease, the rapid advancement of basic science understanding into improved clinical care has been, to use an appropriate term, breathtaking. In this perspective article, I will describe a few of these advances, as they relate to specific pulmonary diseases.
High quality draft genome sequence of an extremely halophilic archaeon Natrinema altunense strain AJ2T
Authors: Cheng Hong , Huo Ying-Yi , Hu Jing , Xu Xue-Wei , Wu Min 
Published: March 2017

AbstractNatrinema altunense strain AJ2T, a halophilic archaeal strain, was isolated from a high-altitude (3884 m) salt lake in Xinjiang, China. This strain requires at least 1.7 M NaCl to grow and can grow anaerobically in the presence of nitrate. To understand the genetics underlying its extreme phenotype, we de novo assembled the entire genome sequence of AJ2T (=CGMCC 1.3731T=JCM 12890T). We assembled 3,774,135 bp of a total of 4.4 Mb genome in only 20 contigs and noted its high GC content (64.6%). Subsequently we predicted the gene content and generated genome annotation to identify the relationship between the epigenetic characteristics and genomic features. The genome sequence contains 52 tRNA genes, 3 rRNA genes and 4,462 protein-coding genes, 3792 assigned as functional or hypothetical proteins in nr database. This Whole Genome Shotgun project was deposited in DDBJ/EMBL/GenBank under the accession JNCS00000000. We performed a Bayesian (Maximum-Likelihood) phylogenetic analysis using 16S rRNA sequence and obtained its relationship to other strains in the Natrinema and Haloterrigena genera. We also confirmed the ANI value between every two species of Natrinema and Haloterrigena genera. In conclusion, our analysis furthered our understanding of the extreme-environment adapted strain AJ2T by characterizing its genome structure, gene content and phylogenetic placement. Our detailed case study will contribute to our overall understanding of why Natrinema strains can survive in such a high-altitude salt lake.
Impact of a New Palliative Care Program on Health System Finances: An Analysis of the Palliative Care Program Inpatient Unit and Consultations at Johns Hopkins Medical Institutions
Authors: Isenberg Sarina R. , Lu Chunhua , McQuade John , Chan Kelvin K.W. , Gill Natasha , Cardamone Michael , Torto Deirdre , Langbaum Terry , Razzak Rab , Smith Thomas J. 
Published: March 2017

Purpose: Palliative care inpatient units (PCUs) can improve symptoms, family perception of care, and lower per-diem costs compared with usual care. In March 2013, Johns Hopkins Medical Institutions (JHMI) added a PCU to the palliative care (PC) program. We studied the financial impact of the PC program on JHMI from March 2013 to March 2014. Methods: This study considered three components of the PC program: PCU, PC consultations, and professional fees. Using 13 months of admissions data, the team calculated the per-day variable cost pre-PCU (ie, in another hospital unit) and after transfer to the PCU. These fees were multiplied by the number of patients transferred to the PCU and by the average length of stay in the PCU. Consultation savings were estimated using established methods. Professional fees assumed a collection rate of 50%. Results: The total positive financial impact of the PC program was $3,488,863.17. There were 153 transfers to the PCU, 60% with cancer, and an average length of stay of 5.11 days. The daily loss pretransfer to the PCU of $1,797.67 was reduced to $1,345.34 in the PCU (−25%). The PCU saved JHMI $353,645.17 in variable costs, or $452.33 per transfer. Cost savings for PC consultations in the hospital, 60% with cancer, were estimated at $2,765,218. $370,000 was collected in professional fees savings. Conclusion: The PCU and PC program had a favorable impact on JHMI while providing expert patient-centered care. As JHMI moves to an accountable care organization model, value-based patient-centered care and increased intensive care unit availability are desirable.
Prior Authorization for Medications in a Breast Oncology Practice: Navigation of a Complex Process
Authors: Agarwal Ankit , Freedman Rachel A. , Goicuria Felicia , Rhinehart Catherine , Murphy Kathleen , Kelly Eileen , Mullaney Erin , St. Amand Myra , Nguyen Phuong , Lin Nancy U. 
Published: March 2017

Introduction: The cost and burden associated with prior authorization (PA) for specialty medications are concerns for oncologists, but the impact of the PA process on care delivery has not been well described. We examined PA processes and approval patterns within a high-volume breast oncology clinic at a major academic cancer center. Methods: We met with institutional staff to create a PA workflow and process map. We then abstracted pharmacy and medical records for all patients with breast cancer (N = 279) treated at our institution who required a PA between May and November 2015 (324 prescriptions). We examined PA approval rates, time to approval, and associations of these outcomes with the type of medication being prescribed, patient demographics, and method of PA. Results: Seventeen possible process steps and 10 decision points were required for patients to obtain medications requiring a PA. Of the 324 PAs tracked, 316 (97.5%) were approved on the first PA request after an average time of 0.82 days (range, 0 to 14 days). Approximately half of PAs were for either palbociclib (26.5%) or pegfilgrastim (22.2%), and 13.6% of PAs were for generic hormonal therapy. Requirements to fax PA requests were associated with greater delay in approval time (1.31 v 0.17 days for online requests; P < .001). The use of specialty pharmacies increased staff burden and delays in medication receipt. Conclusion: The PA process is complicated and labor intensive. Given the high PA approval rate, it is unlikely that PA requirements reduce medication utilization in practice, and these requirements may impose unnecessary burdens on patient care. The goals and requirements for PAs should be readdressed.
Integrated Production, Inventory and Delivery Problems: Complexity and Algorithms
Authors: Li Feng , Chen Zhi-Long , Tang Lixin 
Published: March 2017

We consider several integrated production, inventory, and delivery problems that arise in a number of practical settings where customer orders have pre-specified delivery time windows. These orders are first processed in a plant and then delivered to the customers by transporters (such as trains and air flights) which have fixed delivery departure times. If an order is completed but not immediately delivered by a transporter, the order is kept temporarily in inventory, which incurs an inventory cost. There is a delivery cost for delivering an order, which varies with the departure time. Given a set of orders, the objective is to find an integrated schedule for processing the orders, keeping finished orders in inventory if necessary, and delivering them to the customers such that the total inventory and delivery cost is minimum. We consider two classes of problems: where order delivery is splittable and where order delivery is nonsplittable. For each of the problems considered, we study its computational complexity by either showing that the problem is NP-hard or proposing an algorithm that can find an optimal solution. For the two most general problems, we show that any polynomial time algorithm has an arbitrarily bad worst-case performance bound, and propose combined column generation and tabu search heuristic algorithms that can find near optimal solutions for them in a reasonable computational time. The online appendix is available at https://doi.org/10.1287/ijoc.2016.0726 .
Trochleoplasty with a flexible osteochondral flap
Authors: Metcalfe A. J. , Clark D. A. , Kemp M. A. , Eldridge J. D. 
Published: March 2017

Aims The Bereiter trochleoplasty has been used in our unit for 12 years to manage recurrent patellar instability in patients with severe trochlea dysplasia. The aim of this study was to document the outcome of a large consecutive cohort of patients who have undergone this operation. Patients and Methods Between June 2002 and August 2013, 214 consecutive trochleoplasties were carried out in 185 patients. There were 133 women and 52 men with a mean age of 21.3 years (14 to 38). All patients were offered yearly clinical and radiological follow-up. They completed the following patient reported outcome scores (PROMs): International Knee Documentation Committee subjective scale, the Kujala score, the Western Ontario and McMaster Universities Arthritis Index score and the short-form (SF)-12. Results Outcomes were available for 199 trochleoplasties in 173 patients giving a 93% follow-up rate at a mean of 4.43 years (1 to 12). There were no infections or deep vein thromboses. In total, 16 patients reported further patella dislocation, giving an 8.3% rate of recurrence. There were 27 re-operations, giving a rate of re-operation of 14%. Overall, 88% were satisfied with the operation and 90% felt that their symptoms had been improved. Conclusion All PROMs improved significantly post-operatively except for the mental component score of the SF-12. Trochleoplasty performed using a flexible osteochondral flap is an effective treatment for recurrent patellar instability in patients with severe trochlea dysplasia and gives good results in the medium term. Cite this article: Bone Joint J 2017;99-B:344–50.
Thein vivoeffect of a porous titanium alloy flange with hydroxyapatite, silver and fibronectin coatings on soft-tissue integration of intraosseous transcutaneous amputation prostheses
Authors: Chimutengwende-Gordon M. , Pendegrass C. , Blunn G. 
Published: March 2017

AimsThe Intraosseous Transcutaneous Amputation Prosthesis (ITAP) may improve quality of life for amputees by avoiding soft-tissue complications associated with socket prostheses and by improving sensory feedback and function. It relies on the formation of a seal between the soft tissues and the implant and currently has a flange with drilled holes to promote dermal attachment. Despite this, infection remains a significant risk. This study explored alternative strategies to enhance soft-tissue integration.Materials and MethodsThe effect of ITAP pins with a fully porous titanium alloy flange with interconnected pores on soft-tissue integration was investigated. The flanges were coated with fibronectin-functionalised hydroxyapatite and silver coatings, which have been shown to have an antibacterial effect, while also promoting viable fibroblast growth in vitro. The ITAP pins were implanted along the length of ovine tibias, and histological assessment was undertaken four weeks post-operatively.ResultsThe porous titanium alloy flange reduced epithelial downgrowth and increased soft-tissue integration compared with the current drilled flange. The addition of coatings did not enhance these effects.ConclusionThese results indicate that a fully porous titanium alloy flange has the potential to increase the soft-tissue seal around ITAP and reduce susceptibility to infection compared with the current design. Cite this article: Bone Joint J 2017;99-B:393–400.
Debridement and implant retention in the management of hip periprosthetic joint infection
Authors: Sendi P. , Lötscher P. O. , Kessler B. , Graber P. , Zimmerli W. , Clauss M. 
Published: March 2017

Aims To analyse the effectiveness of debridement and implant retention (DAIR) in patients with hip periprosthetic joint infection (PJI) and the relationship to patient characteristics. The outcome was evaluated in hips with confirmed PJI and a follow-up of not less than two years. Patients and Methods Patients in whom DAIR was performed were identified from our hip arthroplasty register (between 2004 and 2013). Adherence to criteria for DAIR was assessed according to a previously published algorithm. Results DAIR was performed as part of a curative procedure in 46 hips in 42 patients. The mean age was 73.2 years (44.6 to 87.7), including 20 women and 22 men. In 34 hips in 32 patients (73.9%), PJI was confirmed. In 12 hips, the criteria for PJI were not fulfilled and antibiotics stopped. In 41 (89.1%) of all hips and in 32 (94.1%) of the confirmed PJIs, all criteria for DAIR were fulfilled. In patients with exogenous PJI, DAIR was performed not more than three days after referral. In haematogenous infections, the duration of symptoms did not exceed 21 days. In 28 hips, a single debridement and in six hips two surgical debridements were required. In 28 (87.5%) of 32 patients, the total treatment duration was three months. Failure was noted in three hips (9%). Long-term follow-up results (mean 4.0 years, 1.4 to 10) were available in 30 of 34 (88.2%) confirmed PJIs. The overall successful outcome rate was 91% in 34 hips, and 90% in 30 hips with long-term follow-up results. Conclusion Prompt surgical treatment with DAIR, following strict diagnostic and therapeutic criteria, in patients with suspected periprosthetic joint infection, can lead to high rates of success in eradicating the infection. Cite this article: Bone Joint J 2017;99-B:330–6.
The role of the width of the forefoot in the development of Morton’s neuroma
Authors: Park Y. H. , Jeong S. M. , Choi G. W. , Kim H. J. 
Published: March 2017

AimsMorton’s neuroma is common condition of the forefoot, but its aetiology remains unclear. Our aim was to evaluate the relationship between the width of the forefoot and the development of a Morton’s neuroma.Patients and MethodsBetween January 2013 and May 2016, a total of 84 consecutive patients (17 men, 67 women) with a unilateral Morton’s neuroma were enrolled into the study. The involved and uninvolved feet of each patient were compared. A control group of patients with symptoms from the foot, but without a neuroma who were matched for age, gender, affected side, and web space location, were enrolled. The first to fifth intermetatarsal distance, intermetatarsal angle and intermetatarsal distance of involved web space on standing radiographs were assessed.ResultsThe inter- and intra-observer reliability was excellent. The three parameters did not differ significantly between the involved and uninvolved feet. Neither did they differ significantly between the patients and the controls.ConclusionWe conclude that there is no significant relationship between the width of the forefoot and the development of a Morton’s neuroma. Cite this article: Bone Joint J 2017;99-B:365–8.
Improving the accuracy of synovial fluid analysis in the diagnosis of prosthetic joint infection with simple and inexpensive biomarkers
Authors: Sousa R. , Serrano P. , Gomes Dias J. , Oliveira J. C. , Oliveira A. 
Published: March 2017

Aims The aims of this study were to increase the diagnostic accuracy of the analysis of synovial fluid in the differentiation of prosthetic joint infection (PJI) by the addition of inexpensive biomarkers such as the levels of C-reactive protein (CRP), adenosine deaminase (ADA), alpha-2-macrogloblulin (α2M) and procalcitonin. Patients and Methods Between January 2013 and December 2015, synovial fluid and removed implants were requested from 143 revision total joint arthroplasties. A total of 55 patients met inclusion criteria of the receipt of sufficient synovial fluid, tissue samples and removed implants for analysis. The diagnosis of PJI followed the definition from a recent International Consensus Meeting to create two groups of patients; septic and aseptic. Using receiver operating characteristic curves we determined the cutoff values and diagnostic accuracy for each marker. Results There were 23 PJIs and 32 patients with aseptic loosening. The levels of total leucocyte count, proportion of polymorphonuclear leucocytes (PMNs), CRP, ADA and α2M in the synovial fluid were all significantly higher in those with a PJI than in those with aseptic loosening. The levels of procalcitonin were comparable in the two groups. Cutoff values for the optimal performance in the diagnosis of infection were: total leucocyte count > 1463 cells/μL (sensitivity (Sens) 100%, specificity (Spec) 71.9%, positive predictive value (PPV) 71.9%, negative predictive value (NPV) 100%); proportion of PMNs > 81% (Sens 78.3%, Spec 75.0%, PPV 69.2%, NPV 82.8%); CRP > 6.7mg/L (Sens 78.3%, Spec 93.8%, PPV 90.0%, NPV 85.7%); ADA > 61U/L (Sens 78.3%, Spec 96.9%, PPV 94.7%, NPV 86.1%) and α2M > 958 mg/L (Sens 47.8%, Spec 96.9%, PPV 91.7%, NPV 72.1%). The addition of a raised level of CRP or ADA to the total leukocyte count increased the specificity: total leukocyte count > 1463 cells/μL and CRP > 6.7mg/L (Sens 78.3%, Spec 100%, PPV 100%, NPV 86.5%) or with ADA > 61U/L (Sens 78.3%, Spec 96.9%, PPV 94.7%, NPV 86.1%). Conclusion The total leucocyte count in the synovial fluid offers great negative predictive value in the diagnosis of PJI and the addition of more specific markers such as CRP and ADA improves the positive predictive value. Thus the addition of simple and inexpensive markers to the measurement of the leucocyte count in the synovial fluid may reduce the number of equivocal results which demand more expensive investigation. Cite this article: Bone Joint J 2017;99-B:351–7.
POTENCIAL EMPREENDEDOR DE EMPRESÁRIAS DO SETOR TURÍSTICO DE FLORIANÓPOLIS (SC)
Authors: Souza Maria José Barbosa de , Trindade Fernanda De Magalhães , Freire Robson , Lyra Franciane Reinert 
Published: March 2017

O empreendedorismo feminino é um assunto de interesse na atualidade como um fator que exerce impacto nas políticas macroeconômicas dos países. Por essa razão, os estudos sobre gênero em empreendedorismo são reconhecidos por organismos internacionais que estimulam essas iniciativas,
fato que motiva o interesse de acadêmicos em pesquisar o assunto. Com o objetivo de analisar o potencial empreendedor das proprietárias de empresas do setor turístico de Florianópolis (SC), foi realizado um estudo descritivo, com 35 empresárias dessa atividade econômica. Os resultados revelaram que 68% das entrevistadas classificam-se como empreendedoras, de acordo com o instrumento desenvolvido por Carland, Carland e Hoy (1992), com média de 19,9 em um total de 33 pontos possíveis.
Os testes estatísticos comprovaram a existência de diferenças significativas entre as médias obtidas por
esse segmento e as demais entrevistadas, nos fatores traços de personalidade, postura estratégica e propensão ao risco. Porém revelou que não existe associação significativa entre potencial empreendedor e idade, escolaridade e renda da empreendedora e nem com o ramo de atividade e o tempo de existência da empresa.