bluuebunny/crossref_metadata_2025_split huggingface dataset:
One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function
Authors: Wang Xiaoyin , Derakhshandeh Ronak , Liu Jiangtao , Narayan Shilpa , Nabavizadeh Pooneh , Le Stephenie , Danforth Olivia M. , Pinnamaneni Kranthi , Rodriguez Hilda J. , Luu Emmy , Sievers Richard E. , Schick Suzaynn F. , Glantz Stanton A. , Springer Matthew L. 
Published: July 2016

Background
Despite public awareness that tobacco secondhand smoke (SHS) is harmful, many people still assume that marijuana SHS is benign. Debates about whether smoke‐free laws should include marijuana are becoming increasingly widespread as marijuana is legalized and the cannabis industry grows. Lack of evidence for marijuana SHS causing acute cardiovascular harm is frequently mistaken for evidence that it is harmless, despite chemical and physical similarity between marijuana and tobacco smoke. We investigated whether brief exposure to marijuana SHS causes acute vascular endothelial dysfunction.

Methods and Results
We measured endothelial function as femoral artery flow‐mediated dilation (FMD) in rats before and after exposure to marijuana SHS at levels similar to real‐world tobacco SHS conditions. One minute of exposure to marijuana SHS impaired FMD to a comparable extent as impairment from equal concentrations of tobacco SHS, but recovery was considerably slower for marijuana. Exposure to marijuana SHS directly caused cannabinoid‐independent vasodilation that subsided within 25 minutes, whereas FMD remained impaired for at least 90 minutes. Impairment occurred even when marijuana lacked cannabinoids and rolling paper was omitted. Endothelium‐independent vasodilation by nitroglycerin administration was not impaired. FMD was not impaired by exposure to chamber air.

Conclusions
One minute of exposure to marijuana SHS substantially impairs endothelial function in rats for at least 90 minutes, considerably longer than comparable impairment by tobacco SHS. Impairment of FMD does not require cannabinoids, nicotine, or rolling paper smoke. Our findings in rats suggest that SHS can exert similar adverse cardiovascular effects regardless of whether it is from tobacco or marijuana.
Investigation of the Residual in Column-Integrated Atmospheric Energy Balance Using Cloud Objects
Authors: Kato Seiji , Xu Kuan-Man , Wong Takmeng , Loeb Norman G. , Rose Fred G. , Trenberth Kevin E. , Thorsen Tyler J. 
Published: July 2016

Abstract
Observationally based atmospheric energy balance is analyzed using Clouds and the Earth’s Radiant Energy System (CERES)-derived TOA and surface irradiance, Global Precipitation Climatology Project (GPCP)-derived precipitation, dry static and kinetic energy tendency and divergence estimated from ERA-Interim, and surface sensible heat flux from SeaFlux. The residual tends to be negative over the tropics and positive over midlatitudes. A negative residual implies that the precipitation rate is too small, divergence is too large, or radiative cooling is too large. The residual of atmospheric energy is spatially and temporally correlated with cloud objects to identify cloud types associated with the residual. Spatially, shallow cumulus, cirrostratus, and deep convective cloud-object occurrence are positively correlated with the absolute value of the residual. The temporal correlation coefficient between the number of deep convective cloud objects and individual energy components, net atmospheric irradiance, precipitation rate, and the sum of dry static and kinetic energy divergence and their tendency over the western Pacific are 0.84, 0.95, and 0.93, respectively. However, when all energy components are added, the atmospheric energy residual over the tropical Pacific is temporally correlated well with the number of shallow cumulus cloud objects over tropical Pacific. Because shallow cumulus alters not enough atmospheric energy compared to the residual, this suggests the following: 1) if retrieval errors associated with deep convective clouds are causing the column-integrated atmospheric energy residual, the errors vary among individual deep convective clouds, and 2) it is possible that the residual is associated with processes in which shallow cumulus clouds affect deep convective clouds and hence atmospheric energy budget over the tropical western Pacific.
A Textual Processing Model of Risk Communication: Lessons from Typhoon Haiyan
Authors: Lejano Raul P. , Tan Joyce Melcar , Wilson A. Meriwether W. 
Published: July 2016

Abstract
As the world’s urban poor increase in numbers, they become acutely vulnerable to hazards from extreme weather events. On 8 November 2013, Typhoon Haiyan struck the province of Leyte, Philippines, with casualties numbering in the thousands, largely because of the ensuing storm surge that swept the coastal communities. This study investigates the role and dynamics of risk communication in these events, specifically examining the organizational processing of text within a complex institutional milieu. The authors show how the risk communication process failed to convey meaningful information about the predicted storm surge, transmitting and retransmitting the same routine text instead of communicating authentic messages in earnest. The key insight is that, rather than focus solely on the verbatim transmission of a scripted text, risk communication needs to employ various modes of translation and feedback signals across organizational and institutional boundaries. Adaptation will require overcoming organizational rigidities in order to craft proportionate responses to extreme weather events that may lie outside personal and institutional memory. Future work should build upon the textual processing approach to risk communication, expanding it into a comprehensive relational model of environmental cognition.
Early Viscosupplementation After Anterior Cruciate Ligament Reconstruction
Authors: Di Martino Alessandro , Tentoni Francesco , Di Matteo Berardo , Cavicchioli Alessia , Lo Presti Mirco , Filardo Giuseppe , Zaffagnini Stefano , Marcacci Maurilio , Kon Elizaveta 
Published: July 2016

Background: Hyaluronic acid (HA) has been widely used to treat osteoarthritis given its biological and mechanical properties. Because HA is an “intra-articular” treatment approach that affects the joints, it could be used in the management of acute conditions, such as during the early postsurgical phase, to reduce inflammatory stress and improve articular function. Purpose: The aim of the present double-blind, randomized controlled trial was to evaluate pain control and functional recovery provided by a single injection of HA performed the day after anterior cruciate ligament (ACL) reconstruction. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: The study enrolled 60 patients affected by primary, chronic, and symptomatic ACL tear requiring surgical reconstruction. All patients were treated with the same reconstructive technique and rehabilitation protocol. Exclusion criteria were (1) concurrent articular lesion requiring surgical treatment, (2) axial malalignment in the index limb, and (3) functional limitation or pain in the contralateral knee. The day after the procedure, the patients were randomized to receive a single injection of 3 mL HA or 3 mL saline solution after surgical drains were removed. All patients were evaluated at baseline and at 15, 30, 60, and 180 days and 12 months after surgery by use of the following tools: Short Form–36 Health Survey (SF-36), International Knee Documentation Committee (IKDC) subjective score, visual analog scale (VAS) for pain, VAS for general health status, and Tegner score. At each follow-up evaluation, the transpatellar circumference and active and passive range of motion (ROM) of both knees were recorded. Results: No severe adverse events were documented after early viscosupplementation. A significant improvement was documented in both treatment groups. Significant differences were documented in the transpatellar circumference at 60 days and in active ROM at 30 days postoperatively; patients who received HA had better values compared with the placebo group ( P = .022 and .027, respectively). No statistically relevant intergroup differences were found in the clinical scores. Conclusion: The study documented no adverse events and had some positive findings in terms of active ROM recovery and transpatellar circumference reduction. However, the early postoperative application of viscosupplementation did not lead to significant improvement in clinical scores after ACL reconstruction. Registration: NCT02630407 ( ClinicalTrials.gov identifier),
Analysis of the Current Indications for Microfracture of Chondral Lesions in the Hip Joint
Authors: Trask Darrin J. , Keene James S. 
Published: July 2016

Background: Data on the efficacy of microfracture for treatment of chondral defects in the hip are currently limited, and the recommended criteria for its use (minimal osteoarthritis; a focal, contained lesion <4 cm2 in size) have been taken from those that were established for the knee. Purpose: To determine if the current microfracture (ie, knee) criteria are appropriate for chondral lesions in the hip. Study Design: Case series; Level of evidence, 4. Methods: Seventy patients who had hip arthroscopy and 2 years of follow-up after treatment of labral tears and cam and pincer bony deformities, as well as microfracture of full-thickness chondral defects, are the basis of this study. The size and location of the chondral defects were recorded on each patient’s “hip sheet” and operative note at the time of hip arthroscopy and were confirmed from intraoperative photographs. The chondral defects were debrided and microfractured regardless of their size. All hips were assessed with the 100-point modified Harris Hip Score (mHHS) before arthroscopy and at 3, 6, 12, and 24 months after surgery. Patients who had a total hip arthroplasty or repeat arthroscopy during their 2-year follow-up period were assigned poor results. Results: The average age of the 70 patients was 41 years, and the average size of the lesions microfractured was 143 mm2. Outcomes, based on patients’ 2-year mHHS or being assigned a poor result for revision surgery, were as follows: 32 excellent, 11 good, 6 fair, and 21 poor; overall, 43 patients (61%) had good and excellent results, and 27 (39%) had fair and poor results. The revision surgery rate was 24%. Seven of the 70 patients had chondral lesions greater than the recommended size for microfracture in the hip (>400 mm) and ranged from 430 to 750 mm2. Their 2-year outcomes included 3 excellent, 1 good, 1 fair, and 1 poor result; the outcomes were the same as for the 8 patients with medium (200-400 mm2) and the 55 patients with smaller (<200 mm2) lesions ( P = .25). There also was no difference in the 2-year outcomes of the older patients (age ≥50 years; P = .91). Conclusion: Microfracture in the hip should not be limited to the criteria of knee lesions (<400 mm2) or to younger patients (age <50 years). However, the results also indicate that patients with full-thickness cartilage defects can anticipate a high rate of conversion to total hip arthroplasty within 2 years of their microfracture surgery and that only 60% of them will have good/excellent results over that time period.
A small-scale randomised controlled trial of home telemonitoring in patients with severe chronic obstructive pulmonary disease
Authors: Shany Tal , Hession Michael , Pryce David , Roberts Mary , Basilakis Jim , Redmond Stephen , Lovell Nigel , Schreier Guenter 
Published: July 2016

Introduction This was a pilot study to examine the effects of home telemonitoring (TM) of patients with severe chronic obstructive pulmonary disease (COPD). Methods A randomised controlled 12-month trial of 42 patients with severe COPD was conducted. Home TM of oximetry, temperature, pulse, electrocardiogram, blood pressure, spirometry, and weight with telephone support and home visits was tested against a control group receiving only identical telephone support and home visits. Results The results suggest that TM had a reduction in COPD-related admissions, emergency department presentations, and hospital bed days. TM also seemed to increase the interval between COPD-related exacerbations requiring a hospital visit and prolonged the time to the first admission. The interval between hospital visits was significantly different between the study arms, while the other findings did not reach significance and only suggest a trend. There was a reduction in hospital admission costs. TM was adopted well by most patients and eventually, also by the nursing staff, though it did not seem to change patients’ psychological well-being. Discussion Ability to draw firm conclusions is limited due to the small sample size. However the trends of reducing hospital visits warrant a larger study of a similar design. When designing such a trial, one should consider the potential impact of the high quality of care already made available to this patient cohort.
γ−Carboxyethyl hydroxychroman, a metabolite of γ−tocopherol, preserves nitric oxide bioavailability in endothelial cells challenged with high glucose
Authors: Li Youyou , Bharath Leena P , Qian Ying , Ruan Ting , Anandh Babu Pon Velayutham , Bruno Richard S , Symons J David , Jalili Thunder 
Published: July 2016

Endothelial dysfunction occurs when there are imbalances between factors that regulate the synthesis and degradation of nitric oxide (NO•), and has been reported in patients with hyperglycemia and insulin resistance. We reported that supplementation with γ-tocopherol (γ-T) in humans limits impairments in endothelial function otherwise induced by postprandial hyperglycemia. Given the rapid metabolism of γ-T into γ-carboxyethyl hydroxychroman (γ-CEHC), we hypothesized that the vasoprotective activities of γ-T could be attributed to its metabolite γ-CEHC. To test this, human aortic endothelial cells (HAECs) treated with 0 (vehicle control) or 3 µM γ-CEHC for 24 h prior to incubation with normal (5 mM) or high (25 mM) glucose for 48 h. High-glucose increased levels of uncoupled endothelial nitric oxide synthase (eNOS) as evidenced by reduced ( p < 0.05) eNOS dimer:monomer. High glucose also prevented insulin-stimulated increases in p-AktSer473: total Akt, p-eNOSSer1177: total eNOS, and NO• production. These adverse changes were accompanied by increased ( p < 0.05) reactive oxygen species and mRNA expression of inflammatory mediators (VCAM-1, E-selectin, IL-8). However, each deleterious response evoked by high glucose was prevented when HAECs were incubated with γ-CEHC prior to the high glucose challenge. Taken together, our data support the hypothesis that vascular protection provided by γ-T in vivo may be elicited through the bioactivity of its metabolite, γ-CEHC. Furthermore, it is possible that the antioxidant and anti-inflammatory activities of γ-CEHC may mediate this protective activity.
Novel oral anticoagulant management issues for the stroke clinician
Authors: Wassef Andrew , Butcher Ken 
Published: July 2016

Background Four nonvitamin K antagonist oral anticoagulants (NOACs) are approved for stroke prevention in patients with nonvalvular atrial fibrillation (NVAF). Aims In this review, we assemble available evidence for the best management of ischemic and hemorrhagic stroke patients in the context of NOAC use. Summary of review NOACs provide predictable anticoagulation with fixed dosages. The direct thrombin inhibitor dabigatran and direct factor Xa inhibitors apixaban, edoxaban, and rivaroxaban are all noninferior to warfarin for the prevention of ischemic stroke and systemic embolism and are associated with reduced incidence of intracranial hemorrhage. While these agents offer treatment options for NVAF patients, they also present challenges specific to the clinician managing cerebrovascular disease patients. Conclusions We summarize available evidence and current approaches to the initiation, dosing, monitoring and potential reversal of NOACs in stroke patients.
Kirschner wire pin site infection in hand and wrist fractures: incidence rate and risk factors
Authors: van Leeuwen W. F. , van Hoorn B. T. J. A. , Chen N. , Ring D. 
Published: July 2016

Kirschner wires are widely used for skeletal fixation of unstable fractures, but the pin tracks create a potential pathway through the skin and into the bone for bacteria to cause an infection. We tested the null hypothesis that there are no demographic, patient-related, injury, or treatment variables independently associated with the occurrence of pin site infection after percutaneous fixation of hand and wrist fractures using Kirschner wires. A retrospective review of 1213 patients with one or more fractures of the hand and wrist treated with percutaneous Kirschner wire fixation identified 85 patients (7%) who had additional treatment with oral antibiotics, early pin removal, or reoperation related to a pin site infection. We found no factors were independently associated with higher or lower risks of pin site infection in multivariable logistic regression analysis. Pin site infections – most benign – occur in a notable number of patients and we could not identify any modifiable risk factors. Level of Evidence: III
Symptom Levels in Care-Seeking Bangladeshi and Nepalese Adults With Advanced Cancer
Authors: Love Richard Reed , Ferdousy Tahmina , Paudel Bishnu D. , Nahar Shamsun , Dowla Rumana , Adibuzzaman Mohammad , Ahsan Golam Mushih Tanimul , Uddin Miftah , Salim Reza , Ahamed Sheikh Iqbal 
Published: July 2016

Purpose Three-fourths of patients with advanced cancer are reported to suffer from pain. A primary barrier to provision of adequate symptom treatment is failure to appreciate the intensity of the symptoms patients are experiencing. Because data on Bangladeshi and Nepalese patients’ perceptions of their symptomatic status are limited, we sought such information using a cell phone questionnaire. Methods At tertiary care centers in Dhaka and Kathmandu, we recruited 640 and 383 adult patients, respectively, with incurable malignancy presenting for outpatient visits and instructed them for that single visit on one-time completion of a cell phone platform 15-item survey of questions about common cancer-associated symptoms and their magnitudes using Likert scales of 0 to 10. The questions were taken from the Edmonton Symptom Assessment System and the Brief Pain Inventory instruments. Results All but two Bangladeshi patients recruited agreed to study participation. Two-thirds of Bangladeshi patients reported usual pain levels ≥ 5, and 50% of Nepalese patients reported usual pain levels ≥ 4 (population differences significant at P < .001). Conclusion Bangladeshi and Nepalese adults with advanced cancer are comfortable with cell phone questionnaires about their symptoms and report high levels of pain. Greater attention to the suffering of these patients is warranted.
Effect of Intramolecular Hydrogen Bonding on Photocleavage Reaction of (3-Benzazolyl-2-hydroxy-5-methylphenyl) Methyl Acetate
Authors: Honda Takuya , Ishida Yuka , Arai Tatsuo 
Published: July 2016

Abstract
Caged compounds, (3-benzazolyl-2-hydroxy-5-methylphenyl) methyl acetate (HBO-Ac, HBT-Ac, HBI-Ac) were synthesized and their photocleavage reaction were investigated by means of determination of quantum yield of photocleavage reaction as well as absorption and fluorescence spectroscopy and DFT calculation. These compounds are expected to exist as three conformations anti-enol (a), anti-enol (b) and syn-enol and exhibited fluorescence emission due to the tautomer produced by intramolecular hydrogen-atom transfer in anti-enol (a) form. The compounds HBT-Ac and HBI-Ac underwent photocleavage reaction in CH3Cl, CD3OD and aqueous CD3OD, while HBO-Ac underwent photocleavage reaction in CD3OD and aqueous CD3OD but almost no reaction in CDCl3. The photocleavage reaction may take place from anti-enol (a), which is in accordance to the results of DFT calculation and the experimental results that the relative efficiency of photocleavage reaction increased with decreasing the energy level of anti-enol (a) vs. syn-enol in the ground state calculated by DFT. The results obtained in this study suggest that the efficiency of photocleavage reaction depends on the solvent properties and hydrogen-bonding properties of light-absorbing chromophore of caged compounds which control the stability of conformation causing photocleavage reaction.
Mediatization and the ‘molding force’ of the media
Authors: Hepp Andreas 
Published: July 2016

Abstract
The aim of this article is to contribute to the discussion surrounding mediatization by presenting some arguments on how we could include questions of media specificity in an appropriate way. The core argument is that we have to do this by integrating `media specificity' into a theory of communicative practice or action. In doing so, we can grasp media in their institutional and technological sense as `molding force' of communicative action and research them empirically as part of mediatization processes.
Priming religion: The effects of religious issues in the news coverage on public attitudes towards European integration
Authors: Hinrichsen Malte , Boomgaarden Hajo , de Vreese Claes , van der Brug Wouter , Hobolt Sara Binzer 
Published: July 2016

Abstract
Religion can affect public support for the European Union (EU). However, specifying the circumstances under which religion may become a stronger predictor of EU-support has so far been neglected. This article shows that the media play a role in this process and it is investigated to what extent the presence or absence of references to religious issues in EU news coverage primes people's religious attitudes to contribute to their evaluation of the EU. For this purpose, a content analysis of the amount of religious news items in EU coverage in German and Dutch newspapers between 1997 and 2007 was conducted. Two points in time were chosen — 1998, when only a small amount of religious news items appeared in EU coverage, and 2005, when religious items reached a peak. Eurobarometer data were used to test the media priming proposition. The findings show that an increasing religious dimension in media coverage about the EU primes a linkage between religious and political considerations and thus influences the strength of the impact of religion on attitudes towards the EU.
An exploration of adolescents’ sexual contact and conduct risks through mobile phone use
Authors: Vanden Abeele Mariek , Roe Keith , Eggermont Steven 
Published: July 2016

Abstract
This study explores the prevalence and predictors of three sexual contact and conduct risks through mobile phone use among adolescents (N = 540): (1) the exchange of sexually explicit content, (2) the sharing of one's mobile phone number with a stranger from the opposite sex, and (3) participation in anonymous chat rooms on TV. One in three adolescents admits having exchanged sexual content, one in five reports having shared their number with a stranger, and one in ten has participated in TV chat rooms. Contextual predictors were gender, age, having a (romantic) partner, self-esteem, popularity, susceptibility to peer pressure, parent attachment and attitude towards school. Strong mobile phone use predictors were the frequency of text messaging, problematic phone use and using one's phone to avoid face-to-face interactions. However, different patterns emerged for the different mobile phone practices and for girls and boys, indicating the need for further research.