bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate change projections over China using regional climate models forced by two CMIP5 global models. Part II: projections of future climate
Authors: Hui Pinhong , Tang Jianping , Wang Shuyu , Niu Xiaorui , Zong Peishu , Dong Xinning 
Published: January 2018

ABSTRACTThe changes in mean and extreme climate in China during 2020–2060 are detected with both Weather Research and Forecasting and RegCM4, by downscaling the simulations from EC‐EATTH and IPSL‐CM5A under both the RCP4.5 and RCP8.5 scenarios. The climate changes under the two scenarios exhibit similar patterns, with stronger intensity under the RCP8.5 scenario. For the mean precipitation, increases are projected in most regions, with the largest relative increase in the Tarim Basin. Slight drought mainly occurs in the south‐eastern part of China. The frequency of drizzle rain is expected to decrease in all the sub‐regions, but the moderate to heavy rainfall as well as the storm would occur more frequently, especially on the Tibetan Plateau. The whole country would experience much warmer climate in the future, with the strongest warming over the Tibetan Plateau. By detecting the changes in climate extremes, it is indicated that less dry extremes would occur in the wet areas of China, while more dry events in the arid and semiarid regions. The wet extreme indices would increase in most regions, especially in the wet areas. The surface air temperature tends to become extremely warmer in the future over the whole country, with the strongest change over the Tibetan Plateau. The changes in mean and extreme climate depend strongly on the driving global climate models, with wetter and warmer climate in the downscalings over IPSL‐CM5A, and the model physics of the regional climate models also exert great impact on the projections. Finally, the possible mechanisms for the changes of extreme precipitation are discussed. The enhanced summer monsoon in the future transports more moisture to China, which could lead to more summer precipitation. As a result, the wet extremes tend to increase.
Bodenchemische Vertikalgradienten als charakteristische Zustandsgrößen von Waldökosystemen
Authors: Kölling Christian , Hoffmann Manuela , Gulder Hans‐Jürgen 
Published: January 2018

AbstractAnhand von Lysimeteruntersuchungen der Bodenlösung, Untersuchungen der Bodenfestphase und unter Verwendung von Modellvorstellungen wird die Möglichkeit demonstriert, die Zusammensetzung der Bodenlösung teilweise aus den Eigenschaften der Bodenfestphase vorherzusagen. Als Vorhersageparameter erweist sich die im NH4CI‐Extrakt ermittelte Aluminium‐(Basen)sättigung der Kationenaustauscher als besonders geeignet. Der Parameter zeigt ausgeprägte Tiefengradienten, die als charakteristische Zustandsgrößen der jeweiligen Waldökosysteme gelten können. Es wird vorgeschlagen, diese bodenchemische Zustandsgröße aufgrund ihrer ökologischen Bedeutung bei der forstlichen Standortsklassifikation zusätzlich zu den herkömmlichen Klassifikationskriterien zu verwenden.
Why wine tourists visit cellar doors: Segmenting motivation and destination image
Authors: Bruwer Johan , Prayag Girish , Disegna Marta 
Published: January 2018

AbstractThis study examines the relationship between the motivation of wine tourists to visit cellar doors and destination image perception. A survey of tourists resulted in 676 useable questionnaires. Using a novel segmentation method, self‐organizing maps, and bagged clustering, the study identified 5 distinct motivation clusters. These clusters were different on only gender and previous visit to the wine region. Three clusters of destination image were identified using the same segmentation method. Significant relationships were found between the motivation and destination image clusters. Implications for destination marketing and managing the tourist experience at the winery cellar door are discussed.
Characterization of the Slow Molecular Dynamics of Poly(l‐Lactic Acid) in α and α′ Phases, in a Glassy State, and in a Complex with Poly(d‐Lactic Acid) by Solid‐State NMR
Authors: Chen Wei , Zhou Wenxuan , Makita Yuta , Wang Shijun , Yuan Shichen , Konishi Takashi , Miyoshi Toshikazu 
Published: January 2018

AbstractRecently, slow molecular dynamics of poly(l‐lactic acid) (PLLA) by using 1D and 2D exchange NMR are investigated. In this work, slow molecular dynamics of PLLA chains in the α′, a stereocomplex (SC) with poly(d‐lactic acid), and glassy states are investigated in terms of centerband‐only detection of exchange (CODEX) NMR. The mixing‐time dependence of the CODEX data demonstrates that the molecular dynamics of stems become slower in the order of α′, α, and SC. The temperature dependence of the correlation time 〈τc〉 of the helical jump motions in the α and SC phases simply exhibits Arrhenius behaviors, with activation energy, Ea, values of 91 ± 1 and 97 ± 1 kJ mol−1, respectively. In contrast, the temperature dependence of 〈τc〉 in the α′ sample exhibits two Arrhenius lines with substantially different Ea values of 273 ± 12 and 16 ± 14 kJ mol−1 at temperatures below and above 84 °C. The obtained kinetics of molecular dynamics not only establish the relationship between packing structure and dynamics in PLLA polymorphs and in the SC, but also allow for an understanding of the coupled dynamics between the crystalline and amorphous regions at approximately Tg.
Understanding Resource-Conserving Behaviors Among Fishers: Barotrauma Mitigation and the Power of Subjective Norms in Florida's Reef Fisheries
Authors: Crandall Chelsey A. , Garlock Taryn M. , Lorenzen Kai 
Published: January 2018

Abstract
Understanding the factors underlying fishers’ decisions to adopt resource-conserving behaviors is important to successful fisheries management. This study used an online survey to explore factors motivating decisions to use alternative barotrauma mitigation measures (venting and descending) to improve discarded reef fish survival across recreational, charter, and commercial fishers in the state of Florida. A majority of respondents (66–69%) had experienced fish showing gross signs of barotrauma, and more than half of those (52–69%) reported using barotrauma mitigation most of the time when needed. Use of mitigation by other fishers was perceived to be lower (30–57%) and to have declined after removal of a venting tool requirement. Overall, respondents were more likely to have used venting tools (96–99%) than fish descenders (14–27%), and most respondents (81–86%) intended to use venting tools in the future. The theory of planned behavior was used to predict and explain intentions to use venting tools and/or fish descenders based on three variables: attitudes toward the method, subjective norms (i.e., social pressure), and perceived control (i.e., confidence in their ability to use the method). Fishers across sectors perceived venting tools and descenders to be similarly effective in improving released fish survival, but they felt that descenders were more time consuming, difficult to use, and expensive. Subjective norms and perceived control were stronger for venting tools than for descenders. Overall, subjective norms had the strongest influence on fishers’ intention to use either form of mitigation; attitudes and perceived control were also important in the case of descenders. Outreach efforts focusing on re-enforcing subjective norms should have the greatest impact on increasing fishers’ use of barotrauma mitigation methods. Comparatively greater efforts are required to increase the use of descending gear than to increase the use of venting, and care should be taken to avoid strategies that could result in an overall decline of barotrauma mitigation.
Comparison of Diploid and Triploid Saugeye Recruitment, Growth, and Condition in Kansas Impoundments
Authors: Koch Jeff , Steffen Chris , Goeckler Jason , Marteney Ron , Jagels Josh , Brown Bonnie 
Published: January 2018

Abstract
Saugeyes (Walleye Sander vitreus × Sauger S. canadensis) are stocked by natural resource agencies to provide angling opportunities and biological control of abundant small-bodied fishes. Concern has been raised regarding the stocking of fertile diploid saugeyes in Kansas waters due to potential genetic introgression into wild parental stocks and unintended natural reproduction in ecologically sensitive systems. As such, triploid saugeyes have been stocked in Kansas since 2006 but with minimal evaluation. We compared relative recruitment, growth, and condition of diploid and triploid saugeyes after stocking equal numbers of 3–6-d-old diploid and triploid saugeye fry in four Kansas reservoirs for 3 years. Saugeyes were sampled from study reservoirs annually (2014–2016) with autumn night electrofishing, and flow cytometry was used to determine the ploidy of sampled fish. Throughout the study, diploid fish composed approximately 80% of sampled saugeyes. Age-0 year-classes consisted of 67–100% diploid fish, depending on the study reservoir and sampling year. As saugeyes reached ages 1 and 2, similar patterns in relative recruitment were indicated, with diploids outnumbering triploids by approximately four times. At individual study impoundments, diploid saugeyes composed 75–87% of fish from all study year-classes. Mean length of diploid saugeyes was generally greater than that of triploids at age 0, whereas mean lengths at ages 1 and 2 were similar for the two groups. Our results indicate that diploid saugeye fry represent a more efficient stocking option than triploid fry and that managers should carefully balance consideration of the relative recruitment of diploid and triploid saugeyes with potential genetic integration between Sander spp. when conducting supplemental stockings.
Role of microglia in the spinal cord in colon‐to‐bladder neural crosstalk in a rat model of colitis
Authors: Majima Tsuyoshi , Funahashi Yasuhito , Kawamorita Naoki , Takai Shun , Matsukawa Yoshihisa , Yamamoto Tokunori , Yoshimura Naoki , Gotoh Momokazu 
Published: January 2018

AimsWe investigated whether spinal cord microglia are involved in colon‐to‐bladder neural crosstalk in a rat model of colitis.MethodsAdult female SD rats were divided into A) control, B) colitis, and C) colitis + minocycline groups. Experimental colitis was induced by administering 50% trinitrobenzene sulfonic acid into the distal colon in the colitis group and the minocycline group. Minocycline, a microglial inhibitor, was continuously infused into the intrathecal space in the minocycline group. The following investigations were performed on day 7: (1) continuous cystometry (CMG) in an awake condition; (2) nociceptive behavior observation induced by intravesical instillation of resiniferatoxin; (3) toluidine blue staining in the bladder; (4) Immunofluorescence staining for the microglial marker, CD11b, in L6 spinal cord sections; and (5) quantitative RT‐PCR to investigate interleukin‐1β (IL‐1β), chemokine ligand 3 (CCL3), and brain‐derived neurotrophic factor (BDNF) gene expression in the L6 spinal cord.ResultsIn comparison with the control group, the colitis group showed significant increases in (1) micturition frequency during cystometry; (2) resiniferatoxin‐induced freezing behavior (bladder pain); (3) the number of total and degranulated mast cells in the bladder; (4) the number of microglia in the L6 spinal cord, and (5) the expression of IL‐1β, CCL3, and BDNF mRNA in the L6 spinal cord. Moreover, intrathecal administration of minocycline alleviated these pathophysiological findings caused by experimental colitis.ConclusionsSpinal microglia may play an important role in colitis‐induced bladder overactivity and enhanced bladder pain sensitivity in colitis rats.
Predictors of response, progression‐free survival, and overall survival using NANT Response Criteria (v1.0) in relapsed and refractory high‐risk neuroblastoma
Authors: Villablanca Judith G. , Ji Lingyun , Shapira‐Lewinson Adi , Marachelian Araz , Shimada Hiroyuki , Hawkins Randall A. , Pampaloni Miguel , Lai Hollie , Goodarzian Fariba , Sposto Richard , Park Julie R. , Matthay Katherine K. 
Published: January 2018

AbstractPurposeThe New Approaches to Neuroblastoma Therapy Response Criteria (NANTRC) were developed to optimize response assessment in patients with recurrent/refractory neuroblastoma. Response predictors and associations of the NANTRC version 1.0 (NANTRCv1.0) and prognostic factors with outcome were analyzed.MethodsA retrospective analysis was performed of patients with recurrent/refractory neuroblastoma enrolled from 2000 to 2009 on 13 NANT Phase 1/2 trials. NANTRC overall response integrated CT/MRI (Response Evaluation Criteria in Solid Tumors [RECIST]), metaiodobenzylguanidine (MIBG; Curie scoring), and percent bone marrow (BM) tumor (morphology).ResultsFourteen (6.9%) complete response (CR) and 14 (6.9%) partial response (PR) occurred among 203 patients evaluable for response. Five‐year progression‐free survival (PFS) was 16 ± 3%; overall survival (OS) was 27 ± 3%. Disease sites at enrollment included MIBG‐avid lesions (100% MIBG trials; 84% non‐MIBG trials), measurable CT/MRI lesions (48%), and BM (49%). By multivariable analysis, Curie score of 0 (P < 0.001), lower Curie score (P = 0.003), no measurable CT/MRI lesions (P = 0.044), and treatment on peripheral blood stem cell (PBSC) supported trials (P = 0.005) were associated with achieving CR/PR. Overall response of stable disease (SD) or better was associated with better OS (P < 0.001). In multivariable analysis, MYCN amplification (P = 0.037) was associated with worse PFS; measurable CT/MRI lesions (P = 0.041) were associated with worse OS; prior progressive disease (PD; P < 0.001/P < 0.001), Curie score ≥ 1 (P < 0.001; P = 0.001), higher Curie score (P = 0.048/0.037), and treatment on non‐PBSC trials (P = < 0.001/0.003) were associated with worse PFS and OS.ConclusionsNANTRCv1.0 response of at least SD is associated with better OS in patients with recurrent/refractory neuroblastoma. Patient and tumor characteristics may predict response and outcome. Identifying these variables can optimize Phase 1/2 trial design to select novel agents for further testing.
BRIM‐P: A phase I, open‐label, multicenter, dose‐escalation study of vemurafenib in pediatric patients with surgically incurable, BRAF mutation‐positive melanoma
Authors: Chisholm Julia C. , Suvada Jozef , Dunkel Ira J. , Casanova Michela , Zhang Weijiang , Ritchie Natasha , Choi YounJeong , Park Jane , Das Thakur Meghna , Simko Stephen , Wan Rachel Tam Nga , Ferrari Andrea 
Published: January 2018

AbstractBackgroundVemurafenib, a selective inhibitor of BRAF kinase, is approved for the treatment of adult stage IIIc/IV BRAF V600 mutation‐positive melanoma. We conducted a phase I, open‐label, dose‐escalation study in pediatric patients aged 12–17 years with this tumor type (NCT01519323).ProcedurePatients received vemurafenib orally until disease progression. Dose escalation was conducted using a 3 + 3 design. Patients were monitored for dose‐limiting toxicities (DLTs) during the first 28 days of treatment to determine the maximum tolerated dose (MTD). Safety/tolerability, tumor response, and pharmacokinetics were evaluated.ResultsSix patients were enrolled (720 mg twice daily [BID], n = 3; 960 mg BID [n = 3]). The study was terminated prematurely due to low enrollment. No DLTs were observed; thus, the MTD could not be determined. All patients experienced at least one adverse event (AE); the most common were diarrhea, headache, photosensitivity, rash, nausea, and fatigue. Three patients experienced serious AEs, one patient developed secondary cutaneous malignancies, and five patients died following disease progression. Mean steady‐state plasma concentrations of vemurafenib following 720 mg and 960 mg BID dosing were similar or higher, respectively, than in adults. There were no objective responses. Median progression‐free survival and overall survival were 4.4 months (95% confidence interval [CI] = 2.7–5.2) and 8.1 months (95% CI = 5.1–12.0), respectively.ConclusionsA recommended and effective dose of vemurafenib for patients aged 12–17 years with metastatic or unresectable melanoma was not identified. Extremely low enrollment in this trial highlights the importance of considering the inclusion of adolescents with adult cancers in adult trials.
Emotion regulation and positive affect in the context of salivary alpha‐amylase response to pain in children with cancer
Authors: Jenkins Brooke N. , Granger Douglas A. , Roemer Ryan J. , Martinez Ariana , Torres Tara K. , Fortier Michelle A. 
Published: January 2018

AbstractBackgroundChildren with cancer routinely undergo painful medical procedures invoking strong physiological stress responses. Resilience to this pain may be conferred through resources such as emotion regulation strategies and positive affect.ProcedureThis study measured dispositional positive affect in children with cancer (N = 73) and randomly assigned participants to one of three emotion regulation strategy conditions (distraction, reappraisal, or reassurance). Children applied their assigned strategy during an experimental pain procedure (the cold pressor task [CPT]) and provided saliva samples before, immediately after, and 15 min after the CPT. Saliva samples were later assayed for salivary alpha amylase (sAA)—a surrogate marker for autonomic/sympathetic nervous system activity and regulation.ResultsChildren in the reassurance group had sAA levels that continued to rise after completion of the CPT compared to children in the distraction (b = –1.68, P = 0.021) and reappraisal conditions (b = –1.24, P = 0.084). Furthermore, dispositional positive affect moderated the effect of condition such that children in the reassurance group with lower levels of positive affect had sAA levels that continued to rise after completion of the CPT (dy/dx = 1.56, P = 0.027), whereas children in the reassurance condition with higher levels of positive affect did not exhibit this rise (P > 0.05).ConclusionsSpecific emotion regulation strategies, such as distraction and reappraisal, may attenuate the stress response to pain in pediatric patients with cancer, and positive affect may confer resilience in response to pain even with use of less effective coping strategies such as reassurance.
Drug adherence in treatment resistant and in controlled hypertension—Results from the Swedish Primary Care Cardiovascular Database (SPCCD)
Authors: Holmqvist Lina , Boström Kristina Bengtsson , Kahan Thomas , Schiöler Linus , Qvarnström Miriam , Wettermark Björn , Hjerpe Per , Hasselström Jan , Manhem Karin 
Published: January 2018

AbstractPurposeTo assess drug adherence in patients treated with ≥3 antihypertensive drug classes, with both controlled and uncontrolled blood pressure and describe associated factors for nonadherence.MethodsPatients with hypertension, without cardiovascular comorbidity, aged >30 years treated with ≥3 antihypertensive drug classes were followed for 2 years. Both patients with treatment resistant hypertension (TRH) and patients with controlled hypertension were included. Clinical data were derived from a primary care database. Pharmacy refill data from the Swedish Prescribed drug registry was used to calculate proportion of days covered (PDC). Patients with a PDC level ≥ 80% were included.ResultsWe found 5846 patients treated ≥3 antihypertensive drug classes, 3508 with TRH (blood pressure ≥ 140/90), and 2338 with controlled blood pressure (<140/90 mm Hg). TRH patients were older (69.1 vs 65.8 years, P < .0001) but had less diabetes (28.5 vs 31.7%, P < .009) compared with patients with controlled blood pressure. The proportion of patients with PDC ≥ 80% declined with 11% during the first year in both groups. Having diabetes was associated with staying adherent at 1 year (RR 0.82; 95% CI, 0.68‐0.98) whilst being born outside Europe was associated with nonadherence at one and (RR 2.05; 95% CI, 1.49‐2.82).ConclusionsPatients with multiple antihypertensive drug therapy had similar decline in adherence over time regardless of initial blood pressure control. Diabetes was associated with better adherence, which may imply that the structured caregiving of these patients enhances antihypertensive drug treatment.
Ammonia‐free, room temperature, and reusable photochemical bath for the deposition ofZn(S,O)buffer layers inCu(In,Ga)Se2thin‐film solar cells
Authors: Gallanti Serena , Chassaing Elisabeth , Loones Nicolas , Bouttemy Muriel , Etcheberry Arnaud , Lincot Daniel , Naghavi Negar 
Published: January 2018

AbstractToday, chemical bath deposited (CBD) Zn(S,O) is used at the industrial level in Cu(In,Ga)Se2solar cells technology. The state‐of‐the‐art recipes of sulfur‐based buffer layers use thiourea as sulfide ions precursor and ammonia as complexing agent. However, such formulations require high concentrations of reactants, deposition temperatures between 60°C and 80°C with the problem of ammonia losses by evaporation and large water consumption. In this work, a novel bath chemistry for Zn(S,O) buffer layer deposition is developed where the thiourea is replaced by thioacetic acid as a sulfur precursor. The use of this compound allows the photochemical growth of a dense and homogenous Zn(S,O) layer on CIGSe absorbers. The main advantages of this solution compared to classical CBD‐Zn(S,O) bath are the deposition occurs at room temperature, the concentration of chemical precursors is 6 times lower, no use of a complexing agent such as ammonia, the reuse of the same bath at least for 4 consecutive times. The effect of the deposition time, the incident light power during deposition, and the successive use of the solutions on the thickness and composition of the film is discussed by means of scanning electron microscopy, and X‐ray photoelectron spectroscopy analyses. The photovoltaic performance shows conversion efficiencies similar to the classical thiourea/ammonia based process.
Radical polyaddition of difunctional vinyloxirane with thiols for synthesis of linear and networked polysulfides
Authors: Maeda Shinya , Sudo Atsushi , Endo Takeshi 
Published: January 2018

ABSTRACTRadical ring‐opening polyaddition of bifunctional vinyloxirane with multifunctional thiols was investigated. The polyaddition proceeded smoothly via the ring‐opening reaction of the oxirane moiety to afford the corresponding networked polymers bearing vinyl ether and sulfide moieties in the main chain. The thermal properties of the networked polymers and volume changes upon the polyaddition were investigated. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 783–788
Colloidal Clusters of Bimetallic Core–Shell Nanoparticles for Enhanced Sensing of Hydrogen in Aqueous Solution
Authors: Wy Younghyun , Lee Seunghoon , Wi Dae Han , Han Sang Woo 
Published: January 2018

AbstractDeveloping sensitive and stable hydrogen sensors is of great importance for sustainable energy development. Here, a novel hydrogen sensing platform is described based on colloidal clusters of Au@Pd core–shell nanoparticles (Au@Pd NPCs) with characteristic localized surface plasmon resonance (LSPR) properties. Au@Pd NPCs with well‐controlled topologies exhibit highly pronounced sensitivity for LSPR‐based hydrogen sensing in aqueous solution in comparison to their nanoparticle counterparts and previously reported Au–Pd bimetallic nanostructures, which can be attributed to highly promoted plasmonic field resulting from the cluster formation. Furthermore, Au@Pd NPCs show stable sensing capability for repeated hydrogen sensing cycles. The present strategy for devising high‐performance LSPR‐based hydrogen sensors via the controlled assembly of bimetallic nanoparticles can be applied to the development of efficient plasmonic platforms for various sensing applications.