bluuebunny/crossref_metadata_2025_split huggingface dataset:
The interannual sea level variability in the Indian Ocean as simulated by an Ocean General Circulation Model
Authors: Deepa J. S. , Gnanaseelan C. , Kakatkar R. , Parekh A. , Chowdary J. S. 
Published: August 2017

ABSTRACTLimited coverage of tide gauge observations and limited length record of altimeter observations remain inadequate for the Indian Ocean sea level variability studies especially for longer periods. This study takes advantage of Ocean General Circulation Model (OGCM) simulations and ocean reanalysis to explore the interannual variability of sea level in the Indian Ocean. The model simulated sea level anomalies display good correlation with altimetry and reanalysis products. This consistency in model simulations with observations and reanalysis highlights the potential use of this OGCM in understanding the sea level variability. Analysis reveals that co‐occurrence years (years when Indian Ocean Dipole (IOD) and El Niño events co‐occur) contribute significantly towards the interannual variability in the Indian Ocean compared to pure IOD or El Niño events, and are characterized by persistent generation of open ocean downwelling, with maximum signals in the 10° to 5°S region. The OGCM experiments are carried out by modulating the forcing fields over the Pacific and the Indian Ocean to understand the physical mechanisms causing sea level variability. The experiments suggest that the remote forcing from the Pacific Ocean via Indonesian ThroughFlow (ITF) induce significant sea level changes in the southern Indian Ocean only with variability mostly in the decadal time scales and the northern and equatorial Indian Ocean are not affected by ITF. This study also shows that El Niño and IOD‐induced variations in zonal wind stress and wind stress curl mainly contribute the interannual sea level variations in the Indian Ocean. The forcing associated with the co‐occurrence years are multi‐phased with coastal and open ocean forcing. Whereas the pure IOD and El Nino forcing is mainly found only over the open ocean. The decadal variability in the ENSO is primarily responsible for the decadal sea level variability in the Indian Ocean by modulating ITF transport.
Atmospheric rivers over the Bay of Bengal lead to northern Indian extreme rainfall
Authors: Yang Yan , Zhao Tongtiegang , Ni Guangheng , Sun Ting 
Published: August 2017

ABSTRACTAtmospheric rivers (ARs), filamentary patterns of strong water vapour fluxes, play a prominent role in global poleward moisture transport and have profound impacts on extreme rainfalls (ERs). Previous AR research has mainly focused on the mid‐latitude regions, whereas the characteristics of ARs in low latitudes and their relationship with local ERs remain largely unknown. This study investigates the spatiotemporal characteristics of ARs over the Bay of Bengal and their relationship with ERs after landing on the northern Indian subcontinent using the ERA‐Interim reanalysis data. During the study period from 1979 to 2011, a total of 149 ARs have been identified, which feature a bimodal temporal pattern with more events observed in May and October. The AR axes generally stretch northeastwards over the bay and land in Bangladesh and Burma. A total of 24% of ARs occurring during tropical cyclones implies a possible connection between them, in addition to the similar intra‐annual distribution. In summer, as the tropical cyclones are weak and the northward water vapour flux decreases due to topographic blocking of the Western Ghats, it is less likely to form intensified water vapour pathway, though the atmospheric humidity is high in the study region. Furthermore, a close correlation between ARs and ERs is manifested. A large proportion of ARs would lead to ERs, with a small fraction of ERs occur after ARs. In addition, although persistent ARs constitute the majority of identified events, rainfall intensity will not be enhanced by the increase in AR duration. This study enriches the knowledge of AR characteristics in low latitudes and provides new pathways to understand the hydrological cycles in the Indian Peninsula and the Bay of Bengal.
Increased vascularization promotes functional recovery in the transected spinal cord rats by implanted vascular endothelial growth factor‐targeting collagen scaffold
Authors: Wang Lingjun , Shi Qin , Dai Jianwu , Gu Yong , Feng Yu , Chen Liang 
Published: August 2017

ABSTRACTSpinal cord injury (SCI) is global health concern. The effective strategies for SCI are relevant to the improvement on nerve regeneration microenvironment. Vascular endothelial growth factor (VEGF) is an important cytokine for inducing angiogenesis and accelerating nerve system function recovery from injury. We proposed that VEGF could improve nerve regeneration in SCI. However, an uncontrolled delivery system target to injury site not only decreases the therapeutic efficacy but also increases the risk of tumor information. We implanted collagen scaffold (CS) targeted with a constructed protein, collagen‐binding VEGF (CBD‐VEGF), to bridge transected spine cord gap in a rat transected SCI model. Functional and histological examinations were conducted to assess the repair capacity of the delivery system CS/CBD‐VEGF. The results indicated that the implantation of CS/CBD‐VEGF into the model rats improved the survival rate and exerted beneficial effect on functional recovery. The controlled intervention improved the microenvironment, guided axon growth, and promoted neovascularization at the injury site. Therefore, the delivery system with stable binding of VEGF potentially provides a better therapeutic option for SCI. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1024–1034, 2018.
Muscle stem cell activation in a mouse model of rotator cuff injury
Authors: Davies Michael R. , Garcia Steven , Tamaki Stanley , Liu Xuhui , Lee Solomon , Jose Anthony , Pomerantz Jason H. , Feeley Brian T. 
Published: August 2017

ABSTRACTRotator cuff (RC) tears are frequently complicated by muscle atrophy. Muscle stem cells (MuSCs) repair damaged myofibers following injury, but their role in the prevention or pathogenesis of atrophy following RC tears remains undefined. We hypothesized that the RC MuSC population would be affected by supraspinatus (SS) and infraspinatus (IS) tendon transection (TT) compared to uninjured muscle in a mouse model of RC tear. C57BL6/J mice underwent unilateral SS and IS TT and contralateral sham surgery. At 3, 8, or 14 weeks after injury, mice were euthanized, and SS and IS were harvested for FACS sorting of CD31‐/CD45‐/Sca1‐/ITGa7+/VCAM+ MuSCs or histological analysis. Ki‐67+ MuSCs from injured muscle increased 3.4‐fold at 3 weeks (p = 0.03) and 8.1‐fold at 8 weeks (p = 0.04) following TT injury, but returned to baseline by 14 weeks (p = 0.91). Myod1 remained upregulated 3.3‐fold at 3 weeks (p = 0.03) and 2.0‐fold at 14 weeks (p = 0.0003), respectively. Myofiber cross‐sectional area was decreased at both 3 and 14 weeks after injury, but the number of MuSCs per fiber remained relatively constant at 3 (p = 0.3) and 14 (p = 0.6) weeks after TT. In this study, we characterized the longitudinal effect of RC tendon injury on the MuSC population in supraspinatus and infraspinatus muscles. MuSCs are transiently activated, and are not depleted, in spite of persistent muscle atrophy. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1370–1376, 2018.
Non‐destructive detection for mold colonies in rice based on hyperspectra and GWO‐SVR
Authors: Sunli Cong , Jun Sun , Hanping Mao , Xiaohong Wu , Pei Wang , Xiaodong Zhang 
Published: August 2017

AbstractBACKGROUNDMold contamination of grains not only contributes to inedible food, resulting in economic losses, but also leads to mold in humans and livestock, and can even be carcinogenic to them. Rice, as one of the main grain varieties, if stored improperly, is easily susceptible to mildew. In order to detect the total number of mold colonies in rice more accurately, a method based on hyperspectral imaging technology was investigated.RESULTSIn this paper, non‐destructive detection for the total number of mold colonies in rice was performed from the angle of spectral analysis. A determination coefficient of 0.9621 for the calibration set and 0.9511 for the prediction set between the spectral data and number of mold colonies were eventually achieved by establishing the best support vector regression (SVR) model, optimized by the Gray Wolf Optimization (GWO) algorithm.CONCLUSIONHyperspectral imaging technology combined with the optimal model (GWO‐SVR) is feasible for non‐destructive detection of the total number of mold colonies in rice, providing a promising tool for the mold detection of other agricultural products. © 2017 Society of Chemical Industry
Dynamics in the concentrations of health‐promoting compounds: lupeol, mangiferin and different phenolic acids during postharvest ripening of mango fruit
Authors: Vithana Mekhala DK , Singh Zora , Johnson Stuart K 
Published: August 2017

AbstractBACKGROUNDMango fruit (Mangifera indica L.) is renowned for its pleasant taste and as a rich source of health beneficial compounds. The aim of this study was to investigate the changes in concentrations of health‐promoting compounds, namely ascorbic acid, carotenoids, antioxidants, lupeol, mangiferin, total phenols and individual phenolic acids, as well as ethylene production and respiration rates during climacteric ripening in ‘Kensington Pride’ and ‘R2E2’ mango fruit.RESULTSThe climacteric ethylene and respiration peaks were noted on the third day of the fruit ripening period. The concentrations of total carotenoids in the pulp, total antioxidants in both pulp and peel, and total phenols of the peel, lupeol and mangiferin were significantly elevated, whereas the concentration of ascorbic acid declined during post‐climacteric ripening. Gallic, chlorogenic and vanillic acids were identified as the major phenolic acids in both pulp and peel of ‘Kensington Pride’ and ‘R2E2’ mangoes. The concentrations of phenolic acids (gallic, chlorogenic, vanillic, ferulic and caffeic acids) also increased during the post‐climacteric phase. The concentrations of all phenolic compounds were several‐fold higher in the peel than pulp.CONCLUSIONMangoes at post‐climacteric ripening phase offer the highest concentrations of health‐promoting compounds. Peel, at this stage of fruit ripening, could be exploited as a good source for extraction of these compounds. © 2017 Society of Chemical Industry
Comparing conventional Descriptive Analysis and Napping®‐UFP against physiochemical measurements: a case study using apples
Authors: Pickup William , Bremer Phil , Peng Mei 
Published: August 2017

AbstractBACKGROUNDThe extensive time and cost associated with conventional sensory profiling methods has spurred sensory researchers to develop rapid method alternatives, such as Napping® with Ultra‐Flash Profiling (UFP). Napping®‐UFP generates sensory maps by requiring untrained panellists to separate samples based on perceived sensory similarities. Evaluations of this method have been restrained to manufactured/formulated food models, and predominantly structured on comparisons against the conventional descriptive method. The present study aims to extend the validation of Napping®‐UFP (N = 72) to natural biological products; and to evaluate this method against Descriptive Analysis (DA; N = 8) with physiochemical measurements as an additional evaluative criterion.RESULTSThe results revealed that sample configurations generated by DA and Napping®‐UFP were not significantly correlated (RV = 0.425, P = 0.077); however, they were both correlated with the product map generated based on the instrumental measures (P < 0.05). The finding also noted that sample characterisations from DA and Napping®‐UFP were driven by different sensory attributes, indicating potential structural differences between these two methods in configuring samples.CONCLUSIONSOverall, these findings lent support for the extended use of Napping®‐UFP for evaluations of natural biological products. Although DA was shown to be a better method for establishing sensory–instrumental relationships, Napping®‐UFP exhibited strengths in generating informative sample configurations based on holistic perception of products. © 2017 Society of Chemical Industry
Influence of depth and 3D crosstalk on blur in multi‐view 3D displays
Authors: Hong Hyungki 
Published: August 2017

AbstractCurrent 3D crosstalk equation was defined from the characteristics of 3D display using glasses. This equation is not suitable for multi‐view 3D display with larger view number as it gives the inappropriately large value. In 3D display using eyeglass, double images occur at large depth. But, in multi‐view 3D display with larger view number, blur occurs to larger width for the larger depth. Hence, blur phenomenon of multi‐view 3D display was investigated to understand the unique characteristics of multi‐view 3D display. For this purpose, ray tracing S/W was used to simulate 3D display image seen at the designed viewing distance, to calculate the relative luminance distribution, and to quantify the relation between blur and depth. Calculated results showed that incomplete image separation caused the overlap of multiple view images and the blur. Blur edge width (BEW) was proportional to the horizontal disparity and related to the depth. BEWR = (BEW) / (binocular disparity) was newly defined, and its usefulness for 3D characterization was investigated. BEW and BEWR might be useful as new measuring items to characterize multi‐view 3D display regarding 3D crosstalk.
Impact of lympho‐vascular space invasion on tumor characteristics and survival outcome of women with low‐grade serous ovarian carcinoma
Authors: Matsuo Koji , Wong Kwong‐Kwok , Fotopoulou Christina , Blake Erin A. , Robertson Sharon E. , Pejovic Tanja , Frimer Marina , Pardeshi Vishakha , Hu Wei , Choi Jong‐Sun , Sun Charlotte C. , Richmond Abby M. , Marcus Jenna Z. , Hilliard Maren A.M. , Mostofizadeh Sayedamin , Mhawech‐Fauceglia Paulette , Abdulfatah Eman , Post Miriam D. , Saglam Ozlen , Shahzad Mian M.K. , Karabakhtsian Rouzan G. , Ali‐Fehmi Rouba , Gabra Hani , Roman Lynda D. , Sood Anil K. , Gershenson David M. 
Published: August 2017

Background and ObjectivesTo examine association of lympho‐vascular space invasion (LVSI) with clinico‐pathological factors and to evaluate survival of women with low‐grade serous ovarian carcinoma containing areas of LVSI.MethodsThis is a multicenter retrospective study examining consecutive cases of surgically treated stage I‐IV low‐grade serous ovarian carcinoma (n = 178). Archived histopathology slides for the ovarian tumors were reviewed, and LVSI was scored as present or absent. LVSI status was correlated to clinico‐pathological findings and survival outcome.ResultsLVSI was seen in 79 cases (44.4%, 95% confidence interval [CI] 37.1‐51.7). LVSI was associated with increased risk of omental metastasis (87.0% vs 64.9%, odds ratio [OR] 3.62, P = 0.001), high pelvic lymph node ratio (median 12.9% vs 0%, P = 0.012), and malignant ascites (49.3% vs 32.6%, OR 2.01, P = 0.035). On multivariable analysis, controlling for age, stage, and cytoreductive status, presence of LVSI in the ovarian tumor remained an independent predictor for decreased progression‐free survival (5‐year rates 21.0% vs 35.7%, adjusted‐hazard ratio 1.57, 95%CI 1.06‐2.34, P = 0.026). LVSI was significantly associated with increased risk of recurrence in lymph nodes (OR 2.62, 95%CI 1.08‐6.35, P = 0.047).ConclusionLVSI in the ovarian tumor is associated with adverse clinico‐pathological characteristics and decreased progression‐free survival in women with low‐grade serous ovarian carcinoma.
Accreditation Status and Geographic Location of Outpatient Echocardiographic Testing Facilities Among Medicare Beneficiaries: The VALUE‐ECHO Study
Authors: Brown Scott C. , Wang Kefeng , Dong Chuanhui , Yi Li , Marinovic Gutierrez Carolina , Di Tullio Marco R. , Farrell Mary Beth , Burgess Pamela , Gornik Heather L. , Hamburg Naomi M. , Needleman Laurence , Orsinelli David , Robison Susana , Rundek Tatjana 
Published: August 2017

ObjectivesAccreditation of echocardiographic testing facilities by the Intersocietal Accreditation Commission (IAC) is supported by the American College of Cardiology and American Society of Echocardiography. However, limited information exists on the accreditation status and geographic distribution of echocardiographic facilities in the United States. Our study aimed to identify (1) the proportion of outpatient echocardiography facilities used by Medicare beneficiaries that are IAC accredited, (2) their geographic distribution, and (3) variations in procedure type and volume by accreditation status.MethodsAs part of the VALUE‐ECHO (Value of Accreditation, Location, and Utilization Evaluation–Echocardiography) study, we examined the proportion of IAC‐accredited echocardiographic facilities performing outpatient echocardiography in the 2013 Centers for Medicare and Medicaid Services outpatient limited data set (100% sample) and their geographic distribution using geocoding in ArcGIS (ESRI, Redlands, CA).ResultsAmong 4573 outpatient facilities billing Medicare for echocardiographic testing in 2013, 99.6% (n = 4554) were IAC accredited (99.7% in the 50 US states and 86.2% in Puerto Rico). The proportion IAC‐accredited echocardiographic facilities varied by region, with 98.7%, 99.9%, 99.9%, 99.5%, and 86.2% of facilities accredited in the Northeast, South, Midwest, West, and Puerto Rico, respectively (P < .01, Fisher exact test). Of all echocardiographic outpatient procedures conducted (n = 1,890,156), 99.8% (n = 1,885,382) were performed in IAC‐accredited echocardiographic facilities. Most procedures (90.9%) were transthoracic echocardiograms, of which 99.7% were conducted in IAC‐accredited echocardiographic facilities.ConclusionsAlmost all outpatient echocardiographic facilities billed by Medicare are IAC accredited. This accreditation rate is substantially higher than previously reported for US outpatient vascular testing facilities (13% IAC accredited). The uniformity of imaging and interpretation protocols from a single accrediting body is important to facilitate optimal cardiovascular care.
Endoscopic DCR using bipedicled interlacing mucosal flaps
Authors: Mueller Sarina K. , Freitag Suzanne K. , Lefebvre Daniel R. , Bleier Benjamin S. 
Published: August 2017

ObjectiveObstruction of the nasolacrimal duct is a relatively common condition that affects patients of all ages, races, and sexes. The surgical gold standard for complete nasolacrimal duct obstruction and dacryocystitis is dacryocystorhinostomy (DCR). The purpose of this study was to describe a novel, bipedicled interlacing mucosal sparing flap technique for endoscopic DCR (eDCR).MethodsA posteriorly based mucosal flap over the fundus is combined with a novel, anteriorly based mucosal flap over the intraosseus portion of the nasolacrimal duct (NLD). This exposes a wide area of the maxillary bone, allowing for exposure and identification of the NLD/sac complex in a safer, more inferior position. The interlacing mucosal flaps may be replaced at the conclusion of the procedure, thereby minimizing bone exposure and maintaining excellent long‐term patency.ResultsThe authors have utilized this technique in 55 procedures with 100% positive identification of the NLD and lacrimal sac, 0% complication rate, 100% anatomical patency rate, and 96.4% success rate after a minimal follow‐up of 6 months.DiscussionThe bipedicled interlacing flap technique for eDCR provides for safe and reproducible identification of the NLD and lacrimal sac while minimizing bone exposure and restenosis rate.ConclusionThe bipedicled interlacing flap technique for eDCR provides for safe and reproducible identification of the NLD and lacrimal sac while minimizing bone exposure and restenosis rate.Level of EvidenceNA. Laryngoscope, 128:794–797, 2018
Adjuvant photodynamic therapy in head and neck cancer after tumor‐positive resection margins
Authors: van Doeveren Thérèse E. M. , Karakullukçu M. Barış , van Veen Robert L. P. , Lopez‐Yurda Marta , Schreuder Willem H. , Tan I. Bing 
Published: August 2017

ObjectiveIn case of close or positive resection margins after oncological resection in head and neck surgery, additional treatment is necessary. When conventional options are exhausted, photodynamic therapy (PDT) can play a role in achieving clear margins. The purpose of the current study was to evaluate the clinical benefit of PDT as adjuvant therapy next to surgery with positive resection margins. The role of the time interval between surgery and PDT on survival outcomes also was investigated.Study DesignRetrospective cohort analysis.MethodsAdjuvant PDT was performed in patients with a malignancy in the head and neck region with close or positive resection margins who were not eligible for conventional treatment options. The primary endpoint was progression‐free survival. Secondary endpoints were disease‐free survival, overall survival, and optimal time interval between surgery and PDT.ResultsFifty‐four patients were treated with surgery followed by meta‐tetrahydroxyphenylchlorin‐mediated PDT. There was a large diversity in tumor location and histopathology, as well as in time interval between surgery and PDT. The 2‐year progression‐free survival rate was 30%; 2‐year disease‐free survival rate was 28%; and 2‐year overall survival was 51%. Disease‐free survival was significantly better when the time interval between surgery and PDT was ≥ 6 weeks (P = 0.02).ConclusionPDT can be applied as adjuvant therapy after surgery in cases of a malignancy with close or positive tumor resection margins. However, the clinical benefits are yet to be determined. There is a significantly better disease‐free survival with a time interval between surgery and PDT of minimal 6 weeks.Level of Evidence4. Laryngoscope, 128:657–663, 2018
Ser71 of αS1‐Casein is Phosphorylated in Breast Milk—Evidence from Targeted Mass Analysis
Authors: König Simone , Altendorfer Irina , Saenger Thorsten , Bleck Ellen , Vordenbäumen Stefan , Schneider Matthias , Jose Joachim 
Published: August 2017

ScopeThe casein phosphoproteins in mother's milk supply calcium and phosphate ions and make them biologically available to the newborn. Human αS1‐casein is of particular interest being also an autoantigen and proinflammatory cytokine. Phosphorylation of αS1‐casein by casein kinase 2 completely abolishes binding to toll‐like receptor 4 and proinflammatory effects. It is, however, not known, which amino acids are affected. Therefore, breast milk samples were analyzed in an effort to detect the phosphorylation sites of αS1‐casein.Methods and resultsBreast milk samples were tryptically digested. Target tandem MS analysis confirmed the known phosphorylation sites S33 and S41; evidence for pS89 was found in some samples. Experimental support for the presence of pS31 and pS34 was weak. Phosphorylation of a new site in αS1‐casein, S71, was reproducibly measured in all samples, albeit at much lower intensity than pS33 and pS41.ConclusionPhospho‐occupancy rates varied greatly and could not be confidently correlated to other parameters within the cohort of 20 donors. The new phosphosite S71 is located in the neighborhood of the serine‐rich region and may contribute to the cluster of high charge density at normal milk pH, likely exerting an influence on protein tertiary structure and thus function.