bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of OH− activity and temperature on the dissolution rate of compacted montmorillonite under highly alkaline conditions
Authors: Sawaguchi Takuma , Tsukada Manabu , Yamaguchi Tetsuji , Mukai Masayuki 
Published: September 2016

AbstractThe highly alkaline environment induced by cementitious materials in a deep geological disposal system of high-level radioactive waste is likely to alter montmorillonite, the main constituent of bentonite buffer materials. Over long time periods, the alteration may cause the physical and/or chemical barrier functions of the buffer materials to deteriorate. In order to evaluate the long-term alteration behaviour, the dissolution rate, RA (kgm−3 s−1), of compacted pure montmorillonite (Kunipia-F) was investigated experimentally under conditions of hydroxide ion concentration of 0.10—1.0 mol dm−3 at temperatures of 50—90°C. The dissolution rate data, including those from a previous study at 130°C, were formulated as a function of the activity of hydroxide ions, aOH− (mol dm−3), and temperature, T (K), and expressed as RA = 104.5·(aOH−)1.3·e−55000/RT by multiple regression analysis, where R is the gas constant. The dissolution rate of montmorillonite was greater in the compacted montmorillonite than in the compacted sand-bentonite mixtures. The difference can be explained by considering the decrease in aOH− in the mixtures accompanied by dissolution of accessory minerals such as quartz and chalcedony. The dissolution rate model developed for pure montmorillonite is expected to be applied to bentonite mixtures if quantification of the decrease in aOH− is achieved somehow.
Do somatic mutations in de novo MDS predict for response to treatment?
Authors: Schroeder Mark A. , DeZern Amy E. 
Published: September 2016

Abstract
A 68-year-old male with history of hypertension and arthritis presented with bruising and increasing fatigue over several months. He was found to be thrombocytopenic (platelets 30), WCB 2.0 K/mm3, Hg 11.6 g/dL, ANC 870, and 1% circulating blasts. Bone marrow biopsy revealed 40%-50% cellular with multilineage dysplasia and 10% blasts. Cytogenetic genetic studies showed trisomy 2, and translocation (3;21). FISH studies for 5q, 7p, 8, 17p, and 20q abnormalities were negative. Molecular diagnostics were sent to a commercial laboratory to aid in prognostication. These studies showed mutations in TET2 (exons 1- 9 tested) and PHF6 (exons 1-9 tested). No abnormalities in other epigenetic regulators (DNMT3A, ASXL1), RNA splicing (SF3B1, SRSF2, URAF1, ZRSR2), transcription factors (RUNX1 or ETV6), or signaling (CBL, NRAS, KIT, JAK2, MPL) were detected. He was referred for consultation regarding initial treatment. In this elderly patient with preserved organ function and good performance status who is being considered for reduced intensity conditioned allogeneic hematopoietic cell transplant, what should the initial treatment be and can we use the molecular diagnostic results to guide therapy?
The complete genome sequences of sulfur-oxidizing Gammaproteobacteria Sulfurifustis variabilis skN76T and Sulfuricaulis limicola HA5T
Authors: Umezawa Kazuhiro , Watanabe Tomohiro , Miura Aya , Kojima Hisaya , Fukui Manabu 
Published: September 2016

AbstractSulfurifustis variabilis and Sulfuricaulis limicola are autotrophic sulfur-oxidizing bacteria belonging to the family Acidiferrobacteraceae in the order Acidiferrobacterales. The type strains of these species, strain skN76T and strain HA5T, were isolated from lakes in Japan. Here we describe the complete genome sequences of Sulfurifustis variabilis skN76T and Sulfuricaulis limicola HA5T. The genome of Sulfurifustis variabilis skN76T consists of one circular chromosome with size of 4.0 Mbp including 3864 protein-coding sequences. The genome of Sulfuricaulis limicola HA5T is 2.9 Mbp chromosome with 2763 protein-coding sequences. In both genomes, 46 transfer RNA-coding genes and one ribosomal RNA operon were identified. In the genomes, redundancies of the genes involved in sulfur oxidation and inorganic carbon fixation pathways were observed. This is the first report to show the complete genome sequences of bacteria belonging to the order Acidiferrobacterales in the class Gammaproteobacteria.
Reliability, Validity, and Feasibility of a Computer-Based Geriatric Assessment for Older Adults With Cancer
Authors: Hurria Arti , Akiba Chie , Kim Jerome , Mitani Dale , Loscalzo Matthew , Katheria Vani , Koczywas Marianna , Pal Sumanta , Chung Vincent , Forman Stephen , Nathwani Nitya , Fakih Marwan , Karanes Chatchada , Lim Dean , Popplewell Leslie , Cohen Harvey , Canin Beverly , Cella David , Ferrell Betty , Goldstein Leanne 
Published: September 2016

Purpose: The goal of this study was to evaluate the feasibility, reliability, and validity of a computer-based geriatric assessment via two methods of electronic data capture ( SupportScreen and REDCap) compared with paper-and-pencil data capture among older adults with cancer. Methods: Eligible patients were ≥ 65 years old, had a cancer diagnosis, and were fluent in English. Patients were randomly assigned to one of four arms, in which they completed the geriatric assessment twice: (1) REDCap and paper and pencil in sessions 1 and 2; (2) REDCap in both sessions; (3) SupportScreen and paper and pencil in sessions 1 and 2; and (4) SupportScreen in both sessions. The feasibility, reliability, and validity of the computer-based geriatric assessment compared with paper and pencil were evaluated. Results: The median age of participants (N = 100) was 71 years (range, 65 to 91 years) and the diagnosis was solid tumor (82%) or hematologic malignancy (18%). For session 1, REDCap took significantly longer to complete than paper and pencil (median, 21 minutes [range, 11 to 44 minutes] v median, 15 minutes [range, 9 to 29 minutes], P < .01) or SupportScreen (median, 16 minutes [range, 6 to 38 minutes], P < .01). There were no significant differences in completion times between SupportScreen and paper and pencil ( P = .50). The computer-based geriatric assessment was feasible. Few participants (8%) needed help with completing the geriatric assessment (REDCap, n = 7 and SupportScreen, n = 1), 89% reported that the length was “just right,” and 67% preferred the computer-based geriatric assessment to paper and pencil. Test–retest reliability was high (Spearman correlation coefficient ≥ 0.79) for all scales except for social activity. Validity among similar scales was demonstrated. Conclusion: Delivering a computer-based geriatric assessment is feasible, reliable, and valid. SupportScreen methodology is preferred to REDCap.
Chinese Glass Paintings in Bangkok Monasteries
Authors: Patterson Jessica Lee 
Published: September 2016

Abstract
Reverse glass paintings, a form of Chinese export art, were extensively traded in the nineteenth century. Several examples are on display in prominent Thai Buddhist monasteries in Bangkok. King Nangklao of Siam, Rama III, encouraged Sino-Siamese trade that brought Chinese objects and images to nineteenth-century Siam. The ideals of accretion and abundance characteristic of Thai Buddhism and the sinophilia of Rama III facilitated the construction of “Chinese-style” Thai temples. Glass paintings with scenes of the Pearl River Delta, Romance of the Three Kingdoms, auspicious objects, and bird-and-flower compositions were installed in temples and inspired new directions in Thai mural painting.
The Pagoda in Kherlen-Bars: New Understandings of Khitan-Period Towering Pagodas
Authors: Steinhardt Nancy Shatzman 
Published: September 2016

Abstract
The Kherlen-Bars Pagoda is a little-known, undocumented monument in Dornad province of eastern Mongolia. This article argues that the pagoda was built during the period of Khitan rule in North Asia. It begins by comparing it with dated and undated pagodas of the Liao dynasty in eastern Inner Mongolia and Liaoning. The discussion then turns to less tangible aspects of Liao pagoda architecture that are observed at Kherlen-Bars: the relation between a tall monument and lower ones within viewing range, and the relation between a tall Khitan structure and a nearby walled town. A newly discovered Liao pagoda site in Xishanpo, Inner Mongolia, is presented. Finally, the article proposes sources for the three-monument arrangement at Kherlen-Bars in Northern Wei, Northern Qi, and the Silla kingdom of Korea.
The Ligneous Aesthetic of the Postwar Sōsaku Hanga Movement and American Perspectives on the Modern Japanese Culture of Wood
Authors: Winther-Tamaki Bert 
Published: September 2016

Abstract
The Japanese movement of printmaking known as Sōsaku Hanga (“Creative Prints”) received a tremendous boost after World War II from the patronage of collectors associated with the US military. One appeal of Sōsaku prints by Munakata Shikō, Saitō Kiyoshi, Azechi Umetarō, and Maeda Senpan, among others, was their woody sensibility, or ligneous aesthetic. Human figures rendered like pieces of woodcraft and abstract passages of wood-grain printing intrigued American enthusiasts such as James A. Michener and Oliver Statler. The ligneous aesthetic was appreciated for evoking alluring qualities of ancient Japan as well as for its impressive sense of modernity.
Paintings of Traveling Bullock Carts (Panche Tu) in the Song Dynasty (960–1279)
Authors: Cheng Wen-Chien 
Published: September 2016

Abstract
This paper is a study of Song dynasty panche tu (paintings of traveling bullock carts), a unique genre combining elements of jiehua (paintings requiring the aid of measuring tools), landscape, and genre art. As early as the Five Dynasties, bullock carts were represented in paintings showcasing water mills to celebrate technology and its contribution to agricultural prosperity. In the Song period, the realistic representation of bullock carts meandering along the mountain paths of northern landscapes became a distinctive genre. This paper examines the forces contributing to this transformation: a dominant interest in landscape painting and realism, and the grain contribution required of commoners for the defense of the northern frontier.
Analysis of Base-Position Error Rate of Next-Generation Sequencing to Detect Tumor Mutations in Circulating DNA
Authors: Pécuchet Nicolas , Rozenholc Yves , Zonta Eleonora , Pietrasz Daniel , Didelot Audrey , Combe Pierre , Gibault Laure , Bachet Jean-Baptiste , Taly Valérie , Fabre Elizabeth , Blons Hélène , Laurent-Puig Pierre 
Published: September 2016

AbstractBACKGROUNDDetecting single-nucleotide variations and insertions/deletions in circulating tumor DNA is challenging because of their low allele frequency. The clinical use of circulating tumor DNA to characterize tumor genetic alterations requires new methods based on next-generation sequencing.METHODSWe developed a method based on quantification of error rate of each base position [position error rate (PER)]. To identify mutations, a binomial test was used to compare the minor-allele frequency to the measured PER at each base position. This process was validated in control samples and in 373 plasma samples from patients with lung or pancreatic cancer.RESULTSMinimal mutated allele frequencies were 0.003 for single-nucleotide variations and 0.001 for insertions/deletions. Independent testing performed by droplet digital PCR (n = 231 plasma samples) showed strong agreement with the base-PER method (κ = 0.90).CONCLUSIONSTargeted next-generation sequencing analyzed with the base-PER method represents a robust and low cost method to detect circulating tumor DNA in patients with cancer.
Is the $1000 Genome as Near as We Think? A Cost Analysis of Next-Generation Sequencing
Authors: van Nimwegen Kirsten J M , van Soest Ronald A , Veltman Joris A , Nelen Marcel R , van der Wilt Gert Jan , Vissers Lisenka E L M , Grutters Janneke P C 
Published: September 2016

Abstract

BACKGROUND
The substantial technological advancements in next-generation sequencing (NGS), combined with dropping costs, have allowed for a swift diffusion of NGS applications in clinical settings. Although several commercial parties report to have broken the $1000 barrier for sequencing an entire human genome, a valid cost overview for NGS is currently lacking. This study provides a complete, transparent and up-to-date overview of the total costs of different NGS applications.

METHODS
Cost calculations for targeted gene panels (TGP), whole exome sequencing (WES) and whole genome sequencing (WGS) were based on the Illumina NextSeq500, HiSeq4000, and HiSeqX5 platforms, respectively. To anticipate future developments, sensitivity analyses are performed.

RESULTS
Per-sample costs were €1669 for WGS, € 792 for WES and €333 for TGP. To reach the coveted $1000 genome, not only is the long-term and efficient use of the sequencing equipment needed, but also large reductions in capital costs and especially consumable costs are also required.

CONCLUSIONS
WES and TGP are considerably lower-cost alternatives to WGS. However, this does not imply that these NGS approaches should be preferred in clinical practice, since this should be based on the tradeoff between costs and the expected clinical utility of the approach chosen. The results of the present study contribute to the evaluation of such tradeoffs.
Marxism and the computer game
Authors: Kirkpatrick Graeme , Mazierska Ewa , Kristensen Lars 
Published: September 2016

Abstract
This article asks the question, how should the computer game as a new cultural form be assessed from a Marxist perspective? Marxism is a developed theoretical discourse operative in several domains that are potentially relevant to computer games. The first part of our discussion focuses on Marx’s discussion of technology in relation to art and presents his historical dialectic of alienation and disalienation. This dialectic highlights the ambivalence of technology: it is both the condition of possibility of a society of plenty in which humanity is freed from drudgery and yet, with each step forward, it is associated with the imposition of new demands and novel forms of oppression. Viewed in this way, computer games are an important manifestation of digital technology, deeply implicated in new forms of capitalism. In the second section we use Marx’s ideas on art to explore the aesthetics of the new medium. The aesthetic occupies a special place in Marxist thought because it defines a space of reflection in which we can find a momentary escape from the fray of conflictual social relations and from which the future may shine a light. Viewed as a form of art, computer games are also ambivalent. On one side, they have been associated with a revival of play and a new culture of levity and creativity, which has spread as far as contemporary workplaces and even transformed the design of industrial, or productive, technology. At the same time, we argue that there has been no corresponding social transformation – people are not more free as a result of ‘gamification’. Rather, it seems that computer games present a deepening entanglement of aesthetic values (play, freedom, imagination) with technologies of control (interface, system, rules). In conclusion, we suggest that digital games bring the dream of art to life but that the result is not freedom but rather a perversion of play as its facility for opening up imagined spaces is used to restrict access to the space of freedom.
The work of play: Marx and the video games industry in the United Kingdom
Authors: Woodcock Jamie 
Published: September 2016

Abstract
The video games industry in the United Kingdom is profitable and growing at a time when the broader economy is still failing to recover. This has attracted the interests of politicians, committing large investments and tax breaks. Although the headline figures are impressive, the overall structure of the industry is less clear. Within this there are many new organizations, often shaped by start-up culture. Less is known about how work is being organized or the experiences of workers. The approach taken here draws on Marxist theory and an examination of the labour process. It focuses on how capitalism effects the production of video games, including the use of crunch time, the prevalence of sexism, and the widespread use of non-disclosure agreements. The conclusion suggests further enquiries are needed to understand how the struggle between labour and capital is shaping this industry.
Beyond games as political education – neo-liberalism in the contemporary computer game form
Authors: Möring Sebastian , Leino Olli 
Published: September 2016

Abstract
This article introduces the juxtaposed notions of liberal and neo-liberal gameplay in order to show that, while forms of contemporary game culture are heavily influenced by neo-liberalism, they often appear under a liberal disguise. The argument is grounded in Claus Pias’ idea of games as always a product of their time in terms of economic, political and cultural history. The article shows that romantic play theories (e.g. Schiller, Huizinga and Caillois) are circling around the notion of play as ‘free’, which emerged in parallel with the philosophy of liberalism and respective socio-economic developments such as the industrialization and the rise of the nation state. It shows further that contemporary discourse in computer game studies addresses computer game/play as if it still was the romantic form of play rooted in the paradigm of liberalism. The article holds that an account that acknowledges the neo-liberalist underpinnings of computer games is more suited to addressing contemporary computer games, among which are phenomena such as free to play games, which repeat the structures of a neo-liberal society. In those games the players invest time and effort in developing their skills, although their future value is mainly speculative – just like this is the case for citizens of neo-liberal societies.
The master’s digital tools: Cognitive capitalism and non-normative gaming practices
Authors: Frelik Paweł 
Published: September 2016

Abstract
In Games of Empire. Global Capitalisms and Video Games (2009), Nick Dyer-Witheford and Greig de Peuter mobilize the concept of cognitive capitalism as central to the intimate intermeshing of the medium and the late capitalist business practices. Using this concept, the article extends their discussion to a range of non-normative gaming practices and initiatives that have often been presented as subversive or alternative in relation to the dominant gaming regimes. Using the theory of cognitive capitalism, as outlined by Carlo Vercellone and Yann Moulier Boutang, as well as elements of Nick Dyer-Witheford and Greig de Peuter’s argument, the article links these practices to gauge the degree to which they are complicit in the global capitalist practices and contends that while many non-normative gaming practices cannot be subsumed by the same mechanisms of cognitive capitalism that operate in relation to game designers’ ideas, they ultimately contribute to an increase in value of industry-controlled locked IP and have firmly established positions in the circulation of content.
Awakening in ruins: The virtual spectacle of the end of the city in video games
Authors: Fraser Emma 
Published: September 2016

Abstract
With reference to Walter Benjamin’s work on nineteenth-century Paris, and Debord’s work on the spectacle, this article argues that the depiction of ruined cities in video games – as virtual ruins of the present – simultaneously reproduces the empty novelty of the commodity (the phantasmagoria of progress-oriented civilization), and offers a vision of failed progress through counter-spectacle. One means of understanding Benjamin’s dreamworld of modernity is through ruins and rubble – not only as material remnants, but in other visual or artistic forms that might reveal the illusion of progress as a fallacy, particularly in contrast to an urban-focused commodity capitalism. With an emphasis on Fallout 3, Hellgate: London and The Last of Us, and the S.T.A.L.K.E.R series this article argues that, if cities can be read as dreamworlds, and films, art and ruination as the means for awakening, then urban destruction in the virtual sphere can provide a counter to the collective dream of eternal progress.
Reviews
Authors: Johnson Matthew S. S. , Johnson Phylis 
Published: September 2016

Abstract
AN ETHNOGRAPHY OF THOUGHTFUL IMAGINATION
GAMEWORLDS: VIRTUAL MEDIA AND CHILDREN’S EVERYDAY PLAY, SETH GIDDINGS (2014) New York: Bloomsbury, 184 pp., ISBN: 9781623566326, h/bk, $110.00 (USD)
THE RISE OF 360 VIRTUAL REALITY ‘DO-IT-YOURSELF’ MACHINIMA: EVERY WHICH WAY GAMEPLAY
Comparative pharmacoepidemiological study of antihyperglycemic drugs utilization by patients with type 2 diabetes mellitus in Moscow
Authors: Kalashnikova Marina F. , Belousov Dmitrii Y. , Kantemirova Maria A. , Antsiferov Mikhail B. 
Published: September 2016

Background. A pharmaco-epidemiological study comparing the dynamics of different anti-diabetic drugs in patients with type 2 diabetes mellitus (T2DM) in Russia was conducted using data from a diabetes registry.Objective. To assess and compare the frequency of the prescription of oral anti-diabetic medications (OAMs) and insulin and the average cost of anti-hyperglycaemic therapy with different OAMs in 2014 and 2011.Material and methods. A retrospective cohort study was conducted using national diabetic registry data from the city of Moscow. Data for 270,073 patients (≥18 years old) with T2DM registered by 31 December 2014 were analysed using international the ATC/DDD methodology. The average indicated and actual daily dosage ratio was calculated. The cost of anti-hyperglycaemic therapy for оne person/year was calculated.Results. There were no significant differences in prescribed OAMs between 2011 and 2014, despite the availability of new OAM classes (data for 2011 were published in «Diabetes mellitus», 2015, p. 32–46). The tendency to prescribe two groups of OAMs remained unchanged during the 4-year period (Metformin in 40% of patients and sulfonylurea derivatives, in combination or as a monotherapy, in 49.3%). The percentage of patients with T2DM who received insulin therapy increased from 10% in 2011 to 19.2% in 2014. The absence of a significant increase in the average cost of anti-diabetic therapy by 2014 can be explained by an increase in the prescription of different Russian generics for metformin, sulfonylurea derivatives and insulin, which were cheaper than foreign analogues by 30%–60%.Conclusions. The main trends in the treatment of patients with T2DM by 2014 included less frequent combination therapy with metformin and PSM and more frequent monotherapy or combination therapy with insulin. Despite the appearance of new OAM classes in the market, the overall consumption pattern in 2014 did not exceed 5%. The average cost of anti-diabetic therapy for one patient with T2DM in 2014 in Moscow was 7,727 rubles per year.