bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early stage cervical cancer: role of magnetic resonance imaging after conization in determining residual tumor
Authors: Woo Sungmin , Kim Hye Sung , Chung Hyun Hoon , Kim Sang Youn , Kim Seung Hyup , Cho Jeong Yeon 
Published: December 2015

Background Although magnetic resonance imaging (MRI) is currently indispensable in the management of cervical cancer, its role in determining residual tumor in patients with cervical cancer after conization is not well known. Purpose To evaluate the value of MRI after conization in determining residual tumor in patients with FIGO stage IA-IB1 cervical cancer. Material and Methods In this retrospective study, 55 patients underwent conization followed by preoperative MRI and definitive surgery. Two radiologists evaluated the presence of residual tumor on MRI. MRI and preoperative clinical variables were compared between patients with and without residual tumor at final pathology using Student’s t-test or Chi-square test. Association between variables and the presence of residual tumor was assessed using logistic regression analyses and receiver operating characteristic (ROC) curves. Results Residual tumor at final pathology was found in 30 (54.5%) patients. Patients with residual tumor were older, had greater SCC antigen, and more frequently had positive conization margins and identifiable tumor on MRI ( P < 0.008). Multivariate analysis showed that age ( P = 0.008; odds ratio [OR] = 1.140), positive conization margin ( P = 0.016; OR = 11.919), and identifiable tumor on MRI ( P = 0.038; OR = 6.926) were independently predictive of residual tumor. Areas under the curve (AUCs) calculated with age (0.693), SCC antigen (0.755), and identifiable tumor on MRI (0.727) were greater than lymphovascular space invasion (0.517) and histological subtype (0.520, P ≤ 0.049). Otherwise, there were no significant differences in the AUCs derived from different variables ( P = 0.053–0.970). Conclusion Identifiable tumor on MRI after conization in patients with early stage cervical cancer was an independent predictor of residual tumor at final pathology.
Determinants of Return to Play After the Nonoperative Management of Hamstring Injuries in Athletes
Authors: Fournier-Farley Camille , Lamontagne Martin , Gendron Patrick , Gagnon Dany H. 
Published: December 2015

Background: It is important for clinicians to rely on suitable prognosis factors after hamstring injuries because of the high incidence of these injuries and time away from athletic activities. Purpose: To summarize the current literature on factors that influence return to play after a hamstring injury in athletes. Study Design: Systematic review. Methods: A computer-assisted literature search of CINAHL, MEDLINE, Embase, and EBM Reviews databases (and a manual search of the reference lists of all selected articles) was conducted using keywords related to hamstring injuries and return to play. The literature review criteria included (1) patients with an acute hamstring or posterior thigh injury; (2) a randomized controlled trial, cohort study, case-control study, case series, or prospective or retrospective design; (3) information on rehabilitation, physical therapy, clinical assessment, imaging techniques, and return to play; and (4) studies written in English or French. Results: The search strategy identified 914 potential articles, of which 24 met the inclusion criteria. In terms of the clinical assessment, the following factors were associated with a longer recovery time: stretching-type injuries, recreational-level sports, structural versus functional injuries, greater range of motion deficit with the hip flexed at 90°, time to first consultation >1 week, increased pain on the visual analog scale, and >1 day to be able to walk pain free after the injury. As for magnetic resonance imaging studies, the following factors correlated with a longer recovery time: positive findings; higher grade of injury; muscle involvement >75%; complete transection; retraction; central tendon disruption of the biceps femoris; proximal tendon involvement; shorter distance to the ischial tuberosity; length of the hamstring injury; and depth, volume, and large cross-sectional area. With respect to ultrasound studies, the following factors were associated with a poor prognosis: large cross-sectional area, injury outside the musculotendinous junction, hematoma, structural injury, and injury involving the biceps femoris. Lastly, rehabilitation approaches that included hamstring loading during extensive lengthening or 4 daily sessions of static hamstring stretching led to shorter rehabilitation times. Conclusion: Numerous determinants have an effect on return to play after a hamstring injury in athletes. It is important for sports professionals to be aware of those determinants to guide athletes through the rehabilitation process and refine return-to-play strategies.
Sex-Based Differences as a Predictor of Recovery Trajectories in Young Athletes After a Sports-Related Concussion
Authors: Ono Kim E. , Burns Thomas G. , Bearden Donald J. , McManus Susan M. , King Harold , Reisner Andrew 
Published: December 2015

Background: To date, few studies have delineated clear sex-based differences in symptom resolution after a sports-related concussion (SRC), and equivocal results have been identified in sex-based differences on baseline assessments. Purpose: To assess whether female athletes displayed prolonged recovery and more symptoms at baseline and after an SRC compared with male athletes. Study Design: Cohort study; Level of evidence, 3. Methods: The current study assessed 135 male and 41 female athletes (10-18 years old) who participated in high-impact sports in metropolitan Atlanta middle and high schools. All athletes completed a baseline assessment and at least 1 postconcussion assessment from the Immediate Post-Concussion Assessment and Cognitive Testing battery. Longitudinal hierarchical linear modeling was employed to examine individual-level variables and their associations with adolescents’ rates of recovery in concussive symptoms after controlling for age and number of prior concussions. Results: Aggregate symptoms were rated as higher in female athletes compared with male athletes at baseline (mean ± SD: females, 13.49 ± 11.20; males, 4.88 ± 8.74; F(1,175) = 10.59, P < .001) and immediately after a concussion (females: 16.75 ± 18.08; males: 10.58 ± 14.21; F(1,175) = 3.99, P = .05). There were no group differences in the slope of recovery between male and female athletes, indicating generally similar trajectories of change for both groups. Post hoc analyses revealed higher baseline levels of migraine and neuropsychological symptoms in female athletes. Conclusion: Although female athletes in the current study reported increased symptoms, identical recovery patterns were observed in both sexes, suggesting that sex-based differences in concussion recovery are better explained by increased symptom frequency among female athletes when compared with their male counterparts.
Return-to-Sport Outcomes After Revision Anterior Cruciate Ligament Reconstruction Surgery
Authors: Anand Bobby S. , Feller Julian A. , Richmond Anneka K. , Webster Kate E. 
Published: December 2015

Background: There are limited and inconsistent data regarding return-to-sport outcomes after revision anterior cruciate ligament reconstruction (ACLR). Hypothesis: Return-to-sport rates will be lower after revision ACLR when compared with primary ACLR. Study Design: Case series; Level of evidence, 4. Methods: The study cohort consisted of 136 eligible patients who had undergone their first revision ACLR between March 2006 and March 2010. Of these, 109 patients (80%) completed a sports activity survey at a mean 5-year follow-up (range, 3-7 years). Follow-up also included the International Knee Documentation Committee (IKDC) subjective form, Marx Activity Scale, and Knee injury and Osteoarthritis Outcome Score–quality of life (KOOS-QOL) form. Operative details were obtained from the clinical record. Results: After revision ACLR, 46% (95% CI, 37%-55%) of patients returned to their preinjury level of sport, compared with 50% (95% CI, 41%-59%) after the primary reconstruction in the same patients. Of the patients who were not able to return to their preinjury level of sport after primary reconstruction, 33% improved to the point that they were able to do so after revision. Younger patients were more likely to have returned to their same level of sport (58% vs 38%, P < .05), while the rate of return was the same between male and female patients. Those who returned to their preinjury level of sport scored higher Marx ( P < .01), KOOS-QOL ( P < .001), and IKDC scores ( P < .01) than those who did not. Patients with <50% thickness articular cartilage lesions at revision surgery were more likely to have returned to their preinjury level (52% vs 31%, P < .05) and had significantly better Marx ( P < .01), KOOS-QOL ( P < .01), and IKDC scores ( P < .01) at follow-up. The status of the menisci at the time of revision surgery was not associated with rates of return to sport, but patients with an intact medial meniscus had significantly higher KOOS-QOL ( P < .05) scores at follow-up. Conclusion: Return-to-sport rates of patients after revision ACLR were similar to those after their primary surgery but were still lower than the reported rates of ACLR patients who did not need revision surgery. Greater chondral pathologic abnormalities at revision surgery were associated with reduced function at follow-up.
Tele-intervention for children with hearing loss: A comparative pilot study
Authors: Havenga Estienne , Swanepoel De Wet , le Roux Talita , Schmid Brenda 
Published: December 2015

Introduction This pilot study compared tele-intervention to conventional intervention for children with hearing loss in terms of communication performance, parental perceptions and clinician perceptions. Methods A within-subject design was employed, including 10 children with hearing loss and their parents who each received a structurally similar tele-intervention and conventional intervention session in a counterbalanced manner. Quality of communication performance was analysed using a modified Tait video analysis method. Parent and clinician perceptions were collected through rating-scale surveys and thematic analysis of qualitative responses. Results No significant difference ( p > 0.05) was found between tele-intervention and conventional intervention in terms of communication performance of children. Parent perceptions were not significantly different ( p > 0.05) between conventional and tele-intervention in terms of facilitating meaningful communication interaction. Significant differences were evident for parents' comfort level during the session, whether they found it to be a beneficial experience and whether they would like to continue receiving intervention through this method.  Clinician perceptions of conventional and tele-intervention were not significantly different ( p > 0.05) and tele-intervention was deemed a valuable method of service delivery for clients. Discussion This study provides preliminary evidence that tele-intervention is effective for communication intervention and can be a valuable solution to typical barriers such as distance and the shortage of trained interventionists.
Home monitoring of heart failure patients at risk for hospital readmission using a novel under-the-mattress piezoelectric sensor: A preliminary single centre experience
Authors: Bennett Mosi K , Shao Mingyuan , Gorodeski Eiran Z 
Published: December 2015

Introduction A piezoelectric sensor (PS) converts mechanical deformations into electrical signals. We used a contactless under-the-mattress PS to monitor physiological vibrations resulting from breathing, pumping of the heart, and body movements, among individuals at home following hospitalization for heart failure (HF). Our objectives were to assess acceptability of the device in the home, to assess physiological patterns, and to determine if altered patterns correlate with readmission. Methods We conducted a prospective observational study of 30 patients discharged home following HF hospitalization. PS data included a continuous nightly assessment of heart rate, respiration rate, movement rate, rapid and shallow respiration duration, and a behaviour score. We utilized random forest classification to classify average nightly data by readmission status. Results We collected 640 nights of PS data from 29 patients. There were nine readmissions, of which four were for HF. PS monitoring was tolerated by all but one of the participants. We inspected continuous nightly physiological profiles and noted differences between patients who were and were not readmitted. Patients readmitted for HF had higher average heart and respiration rates, and more respiration variability. Average nightly respiratory rate was most predictive of readmission. Discussion We are the first to study nocturnal physiological patterns of HF patients at home using a contactless under-the-mattress monitoring system. We noted patterns that may be unique to patients at risk for readmission due to HF. Respiratory rate was the most important risk-adjusted associate of readmission for HF. Further studies should investigate the efficacy of home PS monitoring in HF populations.
New approach for appreciating the surgeon's satisfaction of braided sutures
Authors: Debbabi Faten , Abdessalem Saber B 
Published: December 2015

Braided suture made with different materials and sizes is commonly used in many surgical interventions. Their key properties include tensile strength during tightening, knot security, surface morphology, knot slippage, and behavior during healing period. We have developed different testing procedures to measure these properties, but selection of suture should be brought under simultaneous considerations of all preferred properties related to surgical interventions and surgeon requirement. In this study, we propose a new approach for appreciation of surgeon satisfaction by using global quality index corresponding to simultaneous satisfaction of several suture properties such as organoleptic and mechanical properties. A global quality index was developed by using desirability functions. A statistical survey based on the evaluation of suture qualities by Tunisian surgeons allowed the determination of surgeon's requirement, weights, and objectives of individual desirability functions corresponding to each suture property. Braided sutures have been submitted to different developed tests for the evaluation of suture properties during healing and tying. The obtained results are converted to individual desirability index in order to evaluate satisfaction degree of each suture property. Finally, geometric and arithmetic mean aggregation are used to determine the global quality by attributing relative weight to each individual satisfaction degree. Global quality index of polyamide-braided sutures fabricated under different braiding conditions was determined. Obtained results allow the identification of optimal suture for specific surgical interventions.
Reduced-intensity transplantation for lymphomas using haploidentical related donors vs HLA-matched unrelated donors
Authors: Kanate Abraham S. , Mussetti Alberto , Kharfan-Dabaja Mohamed A. , Ahn Kwang W. , DiGilio Alyssa , Beitinjaneh Amer , Chhabra Saurabh , Fenske Timothy S. , Freytes Cesar , Gale Robert Peter , Ganguly Siddhartha , Hertzberg Mark , Klyuchnikov Evgeny , Lazarus Hillard M. , Olsson Richard , Perales Miguel-Angel , Rezvani Andrew , Riches Marcie , Saad Ayman , Slavin Shimon , Smith Sonali M. , Sureda Anna , Yared Jean , Ciurea Stefan , Armand Philippe , Salit Rachel , Bolaños-Meade Javier , Hamadani Mehdi 
Published: December 2015

Key Points
Risk of grade III-IV acute and chronic GVHD is significantly lower with haploidentical compared with URD transplantation. Relapse risk, NRM, PFS, and OS was similar in haploidentical transplants compared with unrelated donor transplants.
Sleep disordered breathing in pregnancy
Authors: Izci Balserak Bilgay 
Published: December 2015

Key pointsSleep disordered breathing (SDB) is common and the severity increases as pregnancy progresses.Frequent snoring, older age and high pre-pregnancy body mass index (>25 kg⋅m−2) could be reliable indicators for SDB in early pregnancy.SDB screening tools, including questionnaires, used in the nonpregnant population have poor predictive ability in pregnancy.Accumulating evidence suggests that SDB during pregnancy may be associated with increased risk of adverse pregnancy outcomes, including gestational diabetes and pre-eclampsia. However, the results should be interpreted cautiously because several studies failed to adjust for potential maternal confounders and have other study limitations.There are no pregnancy-specific practice guidelines for SDB treatment. Many clinicians and practices follow recommendations for the treatment in the general population. Women with pre-existing SDB might need to be reassessed, particularly after the sixth month of pregnancy, because symptoms can worsen with nasal congestion and weight gain.Educational aimsTo highlight the prevalence and severity of sleep disordered breathing (SDB) in the pregnant population.To inform readers about risk factors for SDB in pregnancy.To explore the impact of SDB on adverse maternal and fetal outcomes, and biological pathways for associated adverse maternal and fetal outcomes.To introduce current management options for SDB in pregnancy, including medical and behavioural approaches.Sleep disordered breathing (SDB) is very common during pregnancy, and is most likely explained by hormonal, physiological and physical changes. Maternal obesity, one of the major risk factors for SDB, together with physiological changes in pregnancy may predispose women to develop SDB. SDB has been associated with poor maternal and fetal outcomes. Thus, early identification, diagnosis and treatment of SDB are important in pregnancy. This article reviews the pregnancy-related changes affecting the severity of SDB, the epidemiology and the risk factors of SDB in pregnancy, the association of SDB with adverse pregnancy outcomes, and screening and management options specific for this population.
RETRACTED ARTICLE: Growth property at infinity of harmonic functions
Authors: Jiang Zongcai , Hou Linbo , Peixoto-de-Büyükkurt Corchado 
Published: December 2015

AbstractThis paper gives the growth property of certain harmonic functions at infinity in an n-dimensional cone, which generalize the results obtained by Huang and Qiao (Abstr. Appl. Anal. 2012:203096, 2012), Xu et al. (Bound. Value Probl. 2013:262, 2013), Yang and Ren (Proc. Indian Acad. Sci. Math. Sci. 124(2): 175-178, 2014) and Zhao and Yamada (J. Inequal. Appl. 2014:497, 2014) to the conical case.
Ephrin-A5 Is Required for Optimal Fertility and a Complete Ovulatory Response to Gonadotropins in the Female Mouse
Authors: Buensuceso Adrian V. , Son Alexander I. , Zhou Renping , Paquet Marilène , Withers Benjamin M. , Deroo Bonnie J. 
Published: December 2015

Abstract
Follicle growth and ovulation involve the coordinated expression of many genes, driven by FSH and LH. Reports indicate that Eph receptors and ephrins are expressed in the ovary, suggesting roles in follicle growth and/or ovulation. We previously reported FSH-induced expression of ephrin-A5 (EFNA5) and 4 of its cognate Eph receptors in mouse granulosa cells. We now report that female mice lacking EFNA5 are subfertile, exhibit a compromised response to LH, and display abnormal ovarian histology after superovulation. Efna5−/− females litters were 40% smaller than controls, although no difference in litter frequency was detected. The ovarian response to superovulation was also compromised in Efna5−/− females, with 37% fewer oocytes ovulated than controls. These results corresponded with a reduction in ovarian mRNA levels of several LH-responsive genes, including Pgr, Ptgs2, Tnfaip6, Ereg, Btc, and Adamts4, suggesting that Efna5−/− ovaries exhibit a partially attenuated response to LH. Histopathological analysis indicated that superovulated Efna5−/− females exhibited numerous ovarian defects, including intraovarian release of cumulus oocyte complexes, increased incidence of oocytes trapped within luteinized follicles, granulosa cell and follicular fluid emboli, fibrin thrombi, and interstitial hemorrhage. In addition, adult Efna5−/− ovaries exhibited a 4-fold increase in multioocyte follicles compared with controls, although no difference was detected in 3-week-old mice, suggesting the possibility of follicle merging. Our observations indicate that loss of EFNA5 in female mice results in subfertility and imply that Eph-ephrin signaling may also play a previously unidentified role in the regulation of fertility in women.
Moderate Exercise Prevents Functional Remodeling of the Anterior Pituitary Gland in Diet-Induced Insulin Resistance in Rats: Role of Oxidative Stress and Autophagy
Authors: Mercau María E. , Repetto Esteban M. , Perez Matías N. , Martinez Calejman Camila , Sanchez Puch Silvia , Finkielstein Carla V. , Cymeryng Cora B. 
Published: December 2015

Abstract
A sustained elevation of glucocorticoid production, associated with the establishment of insulin resistance (IR) could add to the deleterious effects of the IR state. The aim of this study is to analyze the consequences of long-term feeding with a sucrose-rich diet (SRD) on Pomc/ACTH production, define the underlying cellular processes, and determine the effects of moderate exercise (ME) on these parameters. Animals fed a standard chow with or without 30% sucrose in the drinking water were subjected to ME. Circulating hormone levels were determined, and pituitary tissues were processed and analyzed by immunobloting and quantitative real-time PCR. Parameters of oxidative stress (OxS), endoplasmic reticulum stress, and autophagy were also determined. Rats fed SRD developed a decrease in pituitary Pomc/ACTH expression levels, increased expression of antioxidant enzymes, and induction of endoplasmic reticulum stress and autophagy. ME prevented pituitary dysfunction as well as induction of antioxidant enzymes and autophagy. Reporter assays were performed in AtT-20 corticotroph cells incubated in the presence of palmitic acid. Pomc transcription was inhibited by palmitic acid-dependent induction of OxS and autophagy, as judged by the effect of activators and inhibitors of both processes. Long-term feeding with SRD triggers the generation of OxS and autophagy in the pituitary gland, which could lead to a decline in Pomc/ACTH/glucocorticoid production. These effects could be attributed to an increase in fatty acids availability to the pituitary gland. ME was able to prevent these alterations, suggesting additional beneficial effects of ME as a therapeutic strategy in the management of IR.