bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical evaluation of sintilimab in conjunction with bevacizumab for advanced colorectal cancer with microsatellite stable-type after failure of first-line therapy
Authors: Wang Liang , Diao Yong-Zhi , Ma Xin-Fu , Luo Yu-Shuang , Guo Qi-Jing , Chen Xiao-Qian 
Published: September 2024

BACKGROUND
At present, immune checkpoint inhibitors (ICIs) remain the 1st-line therapy method for patients suffering from high microsatellite instability /deficient mismatch repair metastatic colorectal cancer (mCRC). However, ICI treatments demonstrate minimal therapeutic efficacy against microsatellite stable (MSS)/proficient mismatch repair (pMMR) CRC. This is mainly because this type of tumor is a “cold tumor” with almost no lymphocyte infiltration. Anti-angiogenic drugs have been found to improve the immune microenvironment by promoting many immune cells to enter the immune microenvironment, thereby exerting anti-tumor effects.
AIM
To investigate the effects of ICIs combined with bevacizumab monoclonal antibody on tumor immune cells in MSS/pMMR advanced CRC patients with first-line treatment failure.
METHODS
A total of 110 MSS/pMMR patients with advanced CRC after first-line treatment failure in the Affiliated Hospital of Qinghai University were enrolled for a randomized controlled trial. In short, patients in the experimental group (n = 60) were given sintilimab plus bevacizumab for 4 cycles, and those in the control group (n = 50) patients were treated with FOLFIRI combined with bevacizumab for 4 cycles. The expression levels of cluster of differentiation (CD) 8 (+) T cells, tumor-associated macrophages (TAMs), and cancer-associated fibroblasts (CAFs) were comprehensively evaluated to assess the effects of sintilimab combined with bevacizumab on MSS/pMMR advanced CRC sufferers following failure of 1st-line therapy.
RESULTS
The positive expression rates of CD8 (+) T lymphocytes (30% vs 50%), TAMs (23.30% vs 60%), and CAFs (23.30% vs 50%) before and after treatment in both groups exhibited statistical significance (P < 0.05). Additionally, the therapeutic effects of both groups (partial remission: 26.67% vs 10%; objective response rate: 26.70% vs 10%) were significantly different (P < 0.05). Although the experimental group showed a higher progression-free survival, median progression-free survival, and disease control rate than the control group, the difference was not statistically significant. Moreover, no significant difference in the occurrence rate of drug-related adverse reactions after treatment between the two groups was found (P > 0.05).
CONCLUSION
ICIs in combination with bevacizumab can not only improve the patient’s prognosis but also yield safe and controllable adverse drug reactions in patients suffering from MSS/pMMR advanced CRC after failure to a 1st-line therapy.
Structured magnetic resonance imaging and endoanal ultrasound anal fistulas reporting template (SMART): An interdisciplinary Delphi consensus
Authors: Sudoł-Szopińska Iwona , Garg Pankaj , Mellgren Anders , Spinelli Antonino , Breukink Stephanie , Iacobellis Francesca , Kołodziejczak Małgorzata , Ciesielski Przemysław , Christian Jenssen ,   SMART Collaborative Group, Santoro Giulio Aniello 
Published: September 2024

BACKGROUND
There is still considerable heterogeneity regarding which features of cryptoglandular anal fistula on magnetic resonance imaging (MRI) and endoanal ultrasound (EAUS) are relevant to surgical decision-making. As a consequence, the quality and completeness of the report are highly dependent on the training and experience of the examiners.
AIM
To develop a structured MRI and EAUS template (SMART) reporting the minimum dataset of information for the treatment of anal fistulas.
METHODS
This modified Delphi survey based on the RAND-UCLA appropriateness for consensus-building was conducted between May and August 2023. One hundred and fifty-one articles selected from a systematic review of the literature formed the database to generate the evidence-based statements for the Delphi study. Fourteen questions were anonymously voted by an interdisciplinary multidisciplinary group for a maximum of three iterative rounds. The degree of agreement was scored on a numeric 0–10 scale. Group consensus was defined as a score ≥ 8 for ≥ 80% of the panelists.
RESULTS
Eleven scientific societies (3 radiological and 8 surgical) endorsed the study. After three rounds of voting, the experts (69 colorectal surgeons, 23 radiologists, 2 anatomists, and 1 gastroenterologist) achieved consensus for 12 of 14 statements (85.7%). Based on the results of the Delphi process, the six following features of anal fistulas were included in the SMART: Primary tract, secondary extension, internal opening, presence of collection, coexisting lesions, and sphincters morphology.
CONCLUSION
A structured template, SMART, was developed to standardize imaging reporting of fistula-in-ano in a simple, systematic, time-efficient way, providing the minimum dataset of information and visual diagram useful to referring physicians.
Formation and rupture of liver hematomas caused by intrahepatic gallbladder perforation: A case report and review of literature
Authors: Huang Hong-Wei , Wang Hao , Leng Chao , Mei Bin 
Published: September 2024

BACKGROUND
Gallbladder perforation is a serious complication of acute cholecystitis. Such perforation is a rare but life-threatening situation that can lead to the formation and rupture of liver hematomas. Here, we report a case of a ruptured intrahepatic hematoma caused by intrahepatic gallbladder perforation, and we present a literature review.
CASE SUMMARY
A 70-year-old male was admitted to the hospital with a complaint of right upper quadrant abdominal pain, flustering and dizziness. The preoperative diagnosis was a ruptured malignant liver tumor, and the patient’s medical images and increased level of carbohydrate antigen-199 suggested that the gallbladder had been invaded. However, the tumor was proven to be a liver hematoma secondary to gallbladder perforation after surgery. The patient was discharged uneventfully on the fifteenth postoperative day.
CONCLUSION
Intrahepatic gallbladder perforation is difficult to diagnose preoperatively. Radiological examinations play a crucial role in the diagnosis but only for partial cases. Early diagnosis and appropriate surgery are key to managing this rare condition.
Reassessment of palliative surgery in conversion therapy of previously unresectable hepatocellular carcinoma: Two case reports and review of literature
Authors: Zhu Yang-Bo , Qin Jia-Yi , Zhang Ting-Ting , Zhang Wen-Jin , Ling Qi 
Published: September 2024

BACKGROUND
Most patients with hepatocellular carcinoma (HCC) have lost the opportunity for direct surgery at the time of diagnosis. Transarterial chemoembolization (TACE) combined with immune checkpoint inhibitors or tyrosine kinase inhibitors (TKI) can partially transform some unresectable HCC and improve the prognosis effectively. However, based on the promising prospects of combined targeted and immunotherapy for the effective treatment of HCC, the positive role of palliative surgery in the conversion treatment of advanced HCC urgently needs further intensive re-assessment.
CASE SUMMARY
In this study, we describe two successful cases of "conversion therapy for unresectable HCC" achieved mainly by palliative surgery combined with TACE plus immunotherapy and TKIs. A 48-year-old patient with newly diagnosed HCC, presenting with a 6-cm mass in the segment VII/VIII of the right liver with multiple intrahepatic metastases, could not undergo one-stage radical surgical resection. He underwent palliative surgery with radiofrequency of metastatic lesions and the palliative resection of the primary mass, and received subsequent TACE treatments twice in the early postoperative period (2 weeks and 6 weeks), in addition to targeted and immune combination therapy with sintilimab injection and oral lenvatinib. No evidence of recurrence was observed during the 11-month follow-up period after surgery. The other patient was a 47-year-old patient with massive HCC (18 cm × 15 cm × 4.5 cm) in the left liver with severe cirrhosis. The left portal branch was occluded and a tumor thrombus formed, and the tumor partly involved the middle hepatic vein. The patient underwent palliative surgery of left hemihepatectomy (including resection of the middle hepatic vein) for HCC, followed by three TACE procedures and oral TKIs 2 weeks after surgery. Six months later, the re-examination via computed tomography revealed no tumour activity in the remaining right liver, while magnetic resonance imaging revealed slight local tumor enhancement in the caudate lobe of the liver considered, TACE was performed once again, and during the next follow-up of 10 months did not reveal new intrahepatic lesions or distant metastases.
CONCLUSION
These cases demonstrate that the addition of palliative surgery to conversion therapy in a selected population with a high tumor burden could benefit patients with initially unresectable HCC.
Lung cancer metastasis-induced distal esophageal segmental spasm confirmed by individualized peroral endoscopic myotomy: A case report
Authors: Shi Hong , Chen Su-Yu , Xie Zhao-Fei , Lin Li-Lin , Jiang Yan 
Published: September 2024

BACKGROUND
Peroral endoscopic myotomy (POEM) has been widely performed as a standard treatment for achalasia; however, its efficacy and safety for treating distal esophageal segmental spasms induced by cancer metastasis remain unknown.
CASE SUMMARY
A 72-year-old male was referred to our hospital and complained of progressive dysphagia for two years. Endoscopy revealed a 2 cm long segment esophageal stenosis with intact mucosa and normal cardia. Computed tomography showed a right upper lung mass, and pathology of the right pleural effusion confirmed the diagnosis of right upper lung adenocarcinoma with multiple rib and mediastinal lymph node metastases and right malignant pleural effusion. Individualized POEM was performed first to alleviate dysphagia, and the final diagnosis was changed to esophageal muscle metastasis arising from lung adenocarcinoma. After treatment, the patient could eat soft solid food and received multiple rounds of pembrolizumab-combination chemotherapy. The patient’s progression-free survival was approximately 16 months. Long stable disease was obtained during the 24-month follow-up.
CONCLUSION
The incidence of distal esophageal segmental spasms induced by muscular metastasis arising from lung adenocarcinoma is extremely low. Individualized POEM can effectively improve a patient’s nutritional status before subsequent chemotherapy can be combined with immune checkpoint inhibitors.
PENGARUH GAYA KEPEMIMPINAN TERHADAP KINERJA KARYAWAN PADA PT. REKAYASA CAKRAWALA RESOURCES DIVISI CLEANING SERVICE JAKARTA
Authors: Rahayu Siti , Yahdi MUhammad 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui pengaruh gaya kepemimpinan terhadap kinerjakaryawan di PT. Rekayasa Cakrawala Resources Divisi Cleaning Service di Jakarta. Dengan menggunakan teknik total sampling, seluruh 52 karyawan dijadikan sampel. Hasil analisis regresi menunjukkan bahwa gaya kepemimpinan berpengaruh signifikan terhadap kinerja karyawan, dengan persamaan Y = 4,441 + 0,778X dan nilai thitung sebesar 9,646 yang lebih besar dari ttabel1,680, sehingga Ho ditolak dan Ha diterima. Nilai koefisien determinasi (KD) sebesar 65,0%menunjukkan bahwa gaya kepemimpinan memiliki pengaruh kuat terhadap kinerja karyawan, sementara 35,0% dipengaruhi oleh faktor lain.
Eco-Forge: Sustainable Design and Systems for Product Approach
Authors: Priyadharshini S  , Manikandan G  , Sethuragavan S  , Dr. V E Jayanthi  
Published: September 2024

The globe is dealing with a number of sustainability issues, including environmental racism, ecosystem loss, water depletion, and climate change. The discipline of sustainability is still developing. Human society is dependent on ecosystem services to meet basic biological needs as well as to supply the resources required for advancements in technology and the economy. Circular economies, the integration of renewable energy sources, and robust, inclusive systems tackle global issues are prioritized in contemporary sustainability design. In order to be a useful tool for scholars, practitioners and policymakers are dedicated to building a more resilient and sustainable future. This paper details, objective of managing sustainability, type of approaches for design, troubleshooting, and the importance of sustainability. This review is useful for the manufacturer and consumers to manage the eco-friendly techniques, resource efficiency, and ethical issues in mind will make our coexistence with the earth more resilient and peaceful. This ensures long-term profitability while minimizing environmental effect, striking a balance between human needs and ecological preservation.
Total Root and Shoot Biomass Inhibited by Paclobutrazol Application on Common Landscape Trees
Authors: Rigsby Chad M. , Smiley E. Thomas , Henry Sean , Holmes Liza , Loyd Andrew L. 
Published: September 2024

AbstractBackgroundPaclobutrazol (PBZ) is used in the arboriculture industry to reduce the growth of trees. It works by inhibiting gibberellin biosynthesis, a group of phytohormones associated with cell elongation. A substantial amount of variation exists within the literature as to the impact of PBZ on woody plant root systems. The purpose of this study was to assess the impact of PBZ on belowground growth and biomass allocation among plant species with varying levels of PBZ sensitivity in a controlled setting.MethodsWe treated containerized silver maple, white oak, pecan, laurel oak, and stone pine trees with Cambistat®at the full label rate, one category lower, two categories lower, or water-only controls. After a 14-month incubation period, leaf, stem, and root tissue dry mass were quantified, root:shoot ratios were calculated, the length of the longest root quantified, and total root length of a subset of replicates was estimated. Species were statistically analyzed separately and collectively to assess trends.ResultsPaclobutrazol application resulted in significantly lower root dry mass and total root length for all species analyzed, and significantly reduced longest root length of all species except for silver maple. Across species and dosage combinations, we saw few dose effects on any response variable and no major trends in root:shoot ratios.ConclusionThe impact of PBZ on trees in the landscape appears to be influenced by a number of factors, but we observed relatively consistent results on belowground biomass when growing conditions were uniform in our controlled experiment.
Helmholtz resonator adjustment computational studies, where in order to reduce the vehicle noise level, the resonator waveguide and throat are inside the resonator volume
Authors: Krylova A. S. , Yudin S. I. , Glazkov A. O. , Nadareyshvili G. G. 
Published: September 2024

Introduction (problem statement and relevance). The paper analyzes the impact of changing the position of one of the ring-type Helmholtz resonators in relation to the second one on the adjustment of the required sound attenuation frequency. Along with that, it covers the impact of temperatures and geometrical parameters of the resonators. The relevance of the paper consists in the possibility to predict and update the adjustments originally provided in the design.The purpose of the study is to determine the dependences of the ring-type resonator parameters required for resonant frequency adjustment.Methodology and research methods. The studies were carried out by means of numerical calculations using the finite element method with further introduction of the results in the form of dependence diagrams.Scientific novelty and results. An example of practical application of adjustment of two co-operating resonators is given. At the moment, there is a great number of papers devoted to the classical Helmholtz resonator and its resonant frequency adjustment. But there is no detailed information about the ring-type resonators.Practical significance. The studies conducted are of great practical importance when developing and researching new configurations of Helmholtz resonators within real exhaust systems.
Kulturgut Thüringer Bratwurst wird gefeiert
Authors: Balzer Heike 
Published: September 2024

Die Veranstaltungsreihe Rostkultur, Aktionen anlässlich des 620. Geburtstag der Bratwurst sowie das erste Deutsche Bratwurstmuseum betonen die Bedeutung der Thüringer Bratwurst in der regionalen und nationalen Kultur.
Thüringer Waldquell zieht positive Bilanz
Authors: Balzer Heike 
Published: September 2024

Insbesondere die Absätze von Thüringer Waldquell Mineralwasser entwickeln sich in den zuletzt neu eingeführten 0,75 l GDB Glasmehrwegflaschen positiv. Fast drei Viertel der Thüringer Waldquell-Getränke werden in die wiederverwendbare Mehrweg-Flaschen gefüllt.
Rotkäppchen-Sekte haben jetzt null Alkohol
Authors: Balzer Heike 
Published: September 2024

Rotkäppchen hat im vergangenen Jahr ein Umsatzwachstum von 2,7 Prozent erzielt und führt mit einem Gesamtumsatz von knapp 427 Mio. Euro den Schaumweinmarkt weiterhin an.
Handel und Industrie müssen zusammenrücken
Authors: Tietze Iris , Sobbe Carola 
Published: September 2024

Bei der Young Business Factory der LZ in Kooperation mit Mars Wrigley Deutschland drehte sich alles rund um die Vertriebszusammenarbeit von morgen und die Frage: Wie können Handel und Industrie verantwortungsvoll die Zukunft gestalten? Im M & M’s-Store in Berlin diskutierten Nachwuchsführungskräfte und Speaker Chancen und Beispiele.
Energy Mixed More Fuels with Lower Carbon Contain and Renewable Energy Reduce Carbon Dioxide Emissions: A Review
Authors: Rakhman Sarwono  
Published: September 2024

Abstract -The concentration of CO2 in atmosphere is increase gradually, CO2 as greenhouse gas has impact to the climate change. It’s mostly CO2 gas come from the burning of fossil fuels. Fossil fuels release more carbon dioxide compared to the renewable energy. The concentration of CO2 in atmosphere nowadays is double to the concentration of CO2 before the industrial age. Reducing the entering of CO2 gas into atmosphere by substitution of fuel with low carbon contain and renewables energy are necessary. Energy mixed has been dominated with fossil energy, the CO2 emissions are still high. Energy mixed with more renewable and less fossil fuels energy should be designed for the next scenario. Energy mixed formula is depend on the availability of energy source.
PYROMETALLURGICAL PROCESSING OF RED MUD
Authors: Васюнина Н.В. , Дубова И.В. , Дружинин К.Е. , Гильманшина Т.Р. 
Published: September 2024

Высокожелезистый красный шлам Байера, содержащий более 30% железа, считается бедной железной рудой. В связи с глобальным дефицитом железа во всем мире в последние десятилетия все большее внимание привлекает вопрос о том, как эффективно использовать железо, содержащееся в красном шламе с высоким содержанием железа. Разработана технологическая схема извлечения железа в чугун из красного шлама восстановительной плавкой с последующим быстрым охлаждением для отделения металла от шлака. Было подробно изучено влияние различных параметров эксперимента на извлечение железа из красного шлама, таких как температура, основность шлака и время восстановления. Результаты показали, что разделение металла и шлака было полным. Максимальное извлечение железа в чугун было получено при температуре 1450 °С и составило в среднем в случае использования флюсов с добавлением соды более 99%, согласно остаточному содержанию железа в шлаке, по данным РСА. Оптимальный результат эксперимента имеет большое значение для достижения крупномасштабной и высокоэффективной утилизации красного шлама.
High-iron Bayer red mud, containing more than 30% iron, is considered low-grade iron ore. Due to the global iron deficiency around the world in recent decades, the question of how to effectively utilize the iron contained in high-iron red mud has received increasing attention. In this work, a technological scheme has been developed for the extraction of iron into cast iron from red mud by reduction smelting, followed by rapid cooling to separate the metal from the slag. The influence of various experimental parameters such as temperature, basicity and reduction time on the recovery of iron from red mud was studied in detail. The results showed that the separation between metal and slag was complete. The maximum extraction of iron into cast iron was obtained at a temperature of 1450 oC and amounted to an average of 88.5% in the case of using fluxes without soda and 91.5% in the case of adding soda. The optimal experimental result is of great importance to achieve large-scale and highly efficient recycling of red mud.
FULL-SCALE SIMULATION OF THE OPERATION OF THE SYSTEM OF MECHANIZED FEED OF THE STARTING MIXTURE INTO THE CHANNEL OF THE BUCKET GATE
Authors: Еронько С.П. , Горбатюк С.М. , Кобелев О.А. , Погорелов И.С. 
Published: September 2024

Представлены методика проведения и результаты модельных исследований работы предложенной новой системы механизированной подачи стартовой смеси в канал сталеразливочного ковша. Выполнена проверка правильности принятых технических решений, заложенных в конструкцию разработанной установки и полученных расчетных зависимостей для обоснования ее энергосиловых параметров.
The method of carrying out and the results of model studies of the operation of the proposed new system for the mechanized supply of the starting mixture into the channel of the steel-pouring ladle are presented, which made it possible to verify the correctness of the adopted technical solutions incorporated in the design of the developed installation, and the obtained calculated dependencies to justify its energy-power parameters.
Project Based Learning sebagai Inovasi Pembelajaran untuk Meningkatkan Keterampilan Desain Grafis dalam Pembelajaran Abad ke-21
Authors: Stefany Evy Maya , Diana Luluk Mauli 
Published: September 2024

Perkembangan abad 21 dapat dilihat dengan pesatnya penggunaan teknologi informasi dan komunikasi di berbagai macam bidang kehidupan. Salah satunya dalam dunia pendidikan karena tuntutan dari dunia perkerjaan yang mengharuskan setiap peserta didik memiliki kompetensi yang mumpuni di bidangnya. Penelitian ini bertujuan untuk menerapkan model Project based learning sebagai inovasi pembelajaran untuk meningkatkan keterampilan desain grafis pada pembelajaran abad 21. Penelitian ini menggunakan jenis penelitian deskriptif analisis dengan metode penelitian kualitatif. Partisipan penelitian ini merupakan 80 orang mahasiswa semester 5 Program Studi Pendidikan Informatika Universitas Trunojoyo Madura. Penelitian ini dilakukan pada mata kuliah Desain Grafis pada semester gasal tahun ajaran 2023/2024. Kelas tersebut dilaksanakan secara hybrid baik online maupun offline. Tujuan pembelajarannya yaitu peserta didik memahami konsep, teori serta memiliki keterampilan dalam desain grafis. Hasil yang diperoleh dalam penerapan model PjBL terkait keterampilan desain grafis yaitu: (1) Mahasiswa terfasilitasi untuk mengembangkan kemampuan berkolaborasi selama melaksanakan proses PjBL. Mereka belajar mendengarkan dan menerima pendapat teman lain, mengajak teman yang tidak semangat untuk mengerjakan, bekerjasama mulai dari menemukan ide sampai mengeksekusi projeknya. (2) PjBL juga mengembangkan komunikasi peserta didik. Komunikasi secara informal maupun formal. Komunikasi informal saat mereka bersama dengan teman-teman kelompoknya sedangkan formal saat mereka harus menghubungi audience dan menampilkan product atau performancenya di depan audience tersebut. (3) Kreativitas dan kemampuan berfikir kritis pun terbentuk. Mereka membutuhkan kretavitas dan kemampuan berfikir kritis untuk menemukan ide dan membuat projeknya layak untuk dipresentasikan.