bluuebunny/crossref_metadata_2025_split huggingface dataset:
Illuminating the richness of the ascidian fossil record: a new exceptionally diverse assemblage of ascidian spicules from the Middle Miocene of Bosnia and Herzegovina
Authors: Łukowiak Magdalena , Mandic Oleg , Omalecka Anna , Kallanxhi Mădălina‐Elena , Ćorić Stjepan , Grunert Patrick 
Published: September 2024

AbstractAscidians, or sea squirts, are sac‐like sessile tunicates commonly found in modern seas. Although the oldest ascidians, or at least ascidian‐like tunicates, are mid‐Cambrian in age, the quality of the ascidian fossil record is extraordinarily poor. It mostly consists of isolated finds or low‐diversity assemblages, often represented by mineral spicules. Our study reports the world's most diverse assemblage of ascidian spicules, originating from the Middle Miocene Bogutovo Selo near Ugljevik, Bosnia and Herzegovina. This material includes 31 spicule types, with four assignable to species (Lissoclinum cf. perforatum, Polysyncraton cf. bilobatum, Didemnum cf. vexillum and D. cf. leopardi) and 10 to genera, all belonging to aplousobranchiate ascidians. Comparing our findings with those of two other studies that use modern biological nomenclature, our assemblage shows a closer resemblance to the distant Eocene Australian assemblage than to the Miocene ascidians from Eastern Paratethys. This suggests the persistence of a once‐homogeneous and widely distributed Eocene fauna into the Miocene, while the Eastern Paratethyan basin developed an endemic fauna after the isolation of Eastern Paratethys from the open sea. Some taxa of our assemblage currently inhabit the Mediterranean Sea. The discovery of one species in distant South African waters suggests that tectonic and environmental changes during the Late Miocene, including the closure of the Gibraltar Strait and prior disconnection from the Indian Ocean, may have limited its survival to remote refugia. The study underscores the importance of including spicules in reconstructing ascidian faunas in the geological past, an area that has been surprisingly understudied.
Effect of the Presence of Physiological Disorder Recognized as “yellow berry” on the Quality of Starch in Bread Wheat (Triticum aestivum) and Durum Wheat (Triticum durum)
Authors: Padilla‐Torres Cindy Veronica , López‐Ahumada Guadalupe Amanda , Mondaca‐Fernández Iram , Balderas‐Cortés José de Jesús , Meza‐Montenegro María Mercedes , Serna‐Saldívar Sergio Othon , Sosa‐Yáñez Lorena Carolina , Dórame‐Miranda Ramón Francisco , Gaytán‐Martínez Marcela 
Published: September 2024

AbstractGenetic and environmental factors influence wheat grain quality, including vitreousness, protein, and starch content. Yellow berry (YB), a physiological condition, adversely affects wheat quality, particularly in irrigated fields with limited nitrogen application, leading to starch‐rich, low‐protein grains. This study examines common wheat, used in baking industries, and durum wheat, primarily employs for pasta production. The focus is on investigating how the physicochemical properties of these wheat types change with the presence of YB, that impacts protein content negatively, increasing total starch content. Fourier‐transform infrared spectroscopy reveals structural changes in YB‐affected grains, while X‐ray diffraction indicates varying crystallinity. In determination of amylose, an increase of 6% in bread wheat with YB and 3% in durum wheat with YB is observed. In the case of RVA (Rapid Visco Analyzer) analysis, a notable increase in viscosity is evident in the treatments that included the yellow berry. This finding suggests that YB is associated with substantial modifications in starch properties, such as amylose‐to‐amylopectin ratio, chain length, and degree of branching, among several other components, which may have important implications for the texture and quality of food products. This study calls for further research to mitigate YB's impact and enhances the quality of wheat‐derived foods.
Sorafenib, a Tyrosine Kinase Inhibitor, Synergistically Enhances the Ferroptosis Effects of Asiatic Acid in Hepatocellular Carcinoma Cells
Authors: Chen Yong‐Syuan , Lee Chien‐Hsing , Hsieh Yi‐Hsien , Chiou Hui‐Ling , Hung Ming‐Chun , Lee Hsiang‐Lin 
Published: September 2024

ABSTRACTHepatocellular carcinoma (HCC) remains one of the most common cancers worldwide. Asiatic acid (AA) is a natural triterpene, which is recognized as effect of antioxidant and antitumor. Sorafenib (Sor), an orally target drug, has been applicate for the HCC therapy. However, the synergistic effect of AA and Sor on human HCC is still unclear. Here, we explore the effect of combined treatment with AA and Sor in the HCC cell line SK‐HEP‐1 and HepG2. Compared with treating alone, our results demonstrated that AA combined with Sor synergistically inhibited proliferative rates in MTT assay and colony formation assay. We also found that AA combined with Sor in HCC cells strongly caused cell cycle arrest in G0/G1 phase and affected the protein level of cyclin D1 and SKP2. Furthermore, combination treatment strongly enhanced ferroptosis through cellular accumulation of iron ions, lipid peroxidation, and ferroptosis‐related proteins (GPX4 and FTH1) in HCC cells. In addition, the combined treatment resulted in higher phosphorylation of JNK1/2 in the promotion of ferroptosis than drug treatment alone. These results indicate that AA combined with Sor synergistically improved ferroptosis in HCC cells through the regulation of JNK1/2 signaling. Taken together, the combinatorial strategy may serve as the potential treatment in HCC.
Clinical and histopathological features of a chronic radiation‐induced dermatitis in a dog and management with an ultra‐hydrolysed collagen cream
Authors: Cochet Faivre Noëlle , Dropsy Hélène , Degorce Rubiales Frédérique , Monderna Emanuele 
Published: September 2024

AbstractIn this report, we present a case of chronic radiation‐induced dermatitis, controlled with an ultra‐hydrolysed marine collagen cream. We also describe the clinical and histopathological features of chronic radiation dermatitis in a dog.
Epitheliotropic T‐cell lymphoma in a Syrian hamster (Mesocricetus auratus)
Authors: Stalder Sandro , Kühn Nicolas , Wegelin Maria , Howard Judith , Wernick Morena Bernadette 
Published: September 2024

AbstractA 2‐year‐2‐month‐old, male Syrian hamster (Mesocricetus auratus) was referred for ulceration and encrustation of the abdominal skin. The affected skin was surgically excised. Histological examination revealed changes consistent with an epitheliotropic T‐cell lymphoma. Two months after the surgery, no clinical signs of disease or tumour recurrence were evident. When patients with consistent clinical signs are presented, cutaneous neoplasia should be considered, especially in older animals. Surgical excision may offer short‐term remission for epitheliotropic lymphoma.
Assessment of the impacts of constructing artificial structures on the water quality and hydrological environment of a meandering river
Authors: Kwon Yongju , Kim Jongyeong , Choi Joowon , Kim Taeyang , Cha Sung Min , Kwon Soonchul 
Published: September 2024

AbstractWhen an artificial structure is built in a river, the river changes significantly in water quality and hydraulic properties. In this study, the effects of the weirs constructed in the middle section of a river as a four major rivers restoration project in Korea on water quality and hydrological characteristics were analyzed. For multi‐dimensional data analysis, a self‐organizing map was applied, and statistical techniques including analysis of variation were used. As a result of analysis, the cross‐sectional area of the river increased significantly after the construction of the weir compared to before the construction of the weir, and the flow velocity decreased at a statistically significant level. In the case of water quality, nitrogen, phosphorus, and suspended solids tended to improve after weir construction, and chlorophyll‐a and bacteria tended to deteriorate. Some water quality parameters such as chlorophyll‐a were also affected by seasonal influences. In order to improve the water quality deteriorated by the construction of the weir, it is necessary to consider how to improve the flow velocity of the river through partial opening or operation of the weir. In addition, in order to determine the effect of sedimentation of particulate matter due to the decrease in flow rate, it is necessary to conduct investigations on sediments around weirs in the future.Practitioner Points
Compared to before the construction of the weir, there was no significant change in the flow rate of the river after the construction of the weir.
In the case of chlorophyll‐a and bacteria, the water quality was deteriorated after weir construction.
To improve the deteriorated water quality, it is required to consider the fundamental management of each pollutant source and the flexible operation of both weirs.
For some improved water quality parameters, further research is needed to determine whether these improvements are directly attributable to the construction of a weir.
Effectiveness of laryngeal reinnervation compared to medialization thyroplasty in the treatment of unilateral vocal fold paralysis: A systematic review and network meta‐analysis
Authors: AlGhamdi Muhnnad A. , Alghamdi Lama Nasser , AlQazenli Mohamed Khalid , Alrashid Dhay Saleh , Bakhsh Zainab 
Published: September 2024

AbstractIntroductionUnilateral vocal fold paralysis (ULVP) is characterized by the complete immobility of a single vocal fold which can cause significant health challenges, including voice impairment, difficulty swallowing, and a high risk of aspiration due to glottic incompetency. The aim of this study is to systematically review the effectiveness of laryngeal reinnervation (LR) and medialization thyroplasty (MT) in the treatment of ULVP.Materials and MethodsMedline, PubMed, Cochrane Library, OVID, Scopus, Springer Nature Journals, ScienceDirect, and Directory of Open Access Journals databases were searched. Restriction to non‐English studies were applied. Studies were excluded if subjects had previous treatment for ULVP, if they had co‐existing neuromuscular disease affecting the larynx, and if they had significant non‐laryngeal speech abnormalitiesResultsFifteen articles were reviewed, all conducted between 2003 and 2023. Among the 864 participants included, 48 underwent LR, 348 underwent MT, and the remaining 432 were in the comparison group, which involved injection laryngoplasty (IL), voice therapy (VT), placebo, and medialization with arytenoid adduction. Meta‐analyses compared LR to MT and MT to alternative treatments, revealing a preference for MT. The comparison between LR and MT in the network meta‐analysis yielded a mean difference of 0.33 (95% CI: −11.79, 12.6) favoring the MT group, ranking using SUCRA values highlighted that MT is the best treatment modality followed by LR.DiscussionThe results of the network meta‐analysis and the subgroup meta‐analysis showed that MT is better than alternative treatments that were included in this study. Moreover, management modalities should be individualized to each patient as many factors are important and may affect the final outcomes.ConclusionsWhile the network meta‐analysis indicates that MT may be more effective than alternative treatments for managing ULVP, the results should be interpreted with caution due to potential confounding factors. One notable limitation is the small sample size in the LR group. Despite these limitations, the findings contribute to the existing literature and can help guide future research on optimal interventions for the treatment of ULVP.
Intraoperative wound irrigation to prevent surgical site infection: A systematic review and meta‐analysis
Authors: Filardi Kaique Flavio Xavier Cardoso , Wegner Gustavo Roberto Minetto , dos Santos Arnaldo Bastos , Filardi Rafaela Goes Machado , Vasques Luana Ferreira , Massoni Marília Cardoso , Da Costa Milena Poliana Chimanski 
Published: September 2024

AbstractIntroductionThe potential benefit of intraoperative wound irrigation (IOWI) in preventing surgical site infection (SSI) remains unclear. The use of antimicrobial agents (AMA) or antiseptic agents (ASA) is controversial worldwide.MethodsWe performed a systematic review and meta‐analysis of randomized clinical trials comparing AMA or ASA with saline solution in patients who underwent abdominal surgery. Sub‐analyses were performed on the type of surgery, type of intervention agent, and wound classification.ResultsNineteen studies comprising 4915 patients undergoing abdominal surgery were included. SSI was observed in 207 out of 2504 patients in the intervention group (8.26 %) and 344 out of 2411 patients in the control group (14.27%). Overall, intraoperative wound irrigation (IOWI) with AMA or ASA was associated with a lower SSI (Odds ratio (OR) 0.62; 95% CI 0.47, 0.82; p < 0.01; I2 = 50%). Sub‐analyses have shown a tendency for decreased SSI in patients from emergency surgery (OR 0.46; 95% CI 0.30, 0.70; p < 0.01; I2 = 23%), patients with contaminated wound (OR 0.48; 95% CI 0.31, 0.74; p < 0.01; I2 = 24%), and either the use of AMA or ASA (OR 0.53 vs. 0.65).ConclusionThe overall use of AMA or ASA before skin closure was associated with decreased SSI. Lower rates of SSI were observed in the subgroup analysis. Furthermore, we must consider the critical heterogeneity of the studies.
Anomaly inflow for dipole symmetry and higher form foliated field theories
Authors: Ebisu Hiromi , Honda Masazumi , Nakanishi Taiichi 
Published: September 2024

Abstract
In accordance with recent progress of fracton topological phases, unusual topological phases of matter hosting fractionalized quasiparticle excitations with mobility constraints, new type of symmetry is studied — multipole symmetry, associated with conservation of multipoles. Based on algebraic relation between dipole and global charges, we introduce a series of (d + 1)-dimensional BF theories with p-form gauge fields, which admit dipole of spatially extended excitations, and study their physical properties. We elucidate that gauge invariant loops have unusual form, containing linear function of the spatial coordinate, which leads to the position dependent braiding statistics and unusual ground state degeneracy dependence on the system size. We also show that the theories exhibit a mixed ’t Hooft anomaly between p-form and (d − p)-form dipole symmetries, which is canceled by an invertible theory defined in one dimensional higher via anomaly inflow mechanism.
Beyond Hawks and Doves: Can inequality ease coordination?
Authors: Bigoni Maria , De Paz Mario Blazquez , Le Coq Chloé 
Published: September 2024

AbstractIt is often argued that inequality may worsen coordination failures as it exacerbates conflicts of interests, making it difficult to achieve an efficient outcome. This paper shows that this needs not to be always the case. In a context in which two interacting populations have conflicting interests, we introduce ex-ante inequality, by making one population stronger than the other. This reduces the cost of miscoordination for the weakest population, and at the same time it makes some equilibria more equitable than others, thus more focal and attractive for inequality-averse players. Hence, both social preferences and strategic risk considerations may ease coordination. We provide experimental support for this hypothesis, by considering an extended two-population Hawk–Dove game, where ex-ante inequality, number of pure-strategy equilibria, and cost of coordination vary across treatments. We find that subjects coordinate more often on the efficient outcomes in the treatment with ex-ante inequality.
Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines
Authors: Ledwith Rico , Stobernack Tobias , Bergert Antje , Bahl Aileen , Pink Mario , Haase Andrea , Dumit Verónica I. 
Published: September 2024

AbstractProteomic investigations result in high dimensional datasets, but integration or comparison of different studies is hampered by high variances due to different experimental setups. In addition, cell culture conditions can have a huge impact on the outcome. This study systematically investigates the impact of experimental parameters on the proteomic profiles of commonly used cell lines—A549, differentiated THP-1 macrophage-like cells, and NR8383—for toxicity studies. The work focuses on analyzing the influence at the proteome level of cell culture setup involving different vessels, cell passage numbers, and post-differentiation harvesting time, aiming to improve the reliability of proteomic analyses for hazard assessment. Mass-spectrometry-based proteomics was utilized for accurate protein quantification by means of a label-free approach. Our results showed that significant proteome variations occur when cells are cultivated under different setups. Further analysis of these variations revealed their association to specific cellular pathways related to protein misfolding, oxidative stress, and proteasome activity. Conversely, the influence of cell passage numbers on the proteome is minor, suggesting a reliable range for conducting reproducible biological replicates. Notable, substantial proteome alterations occur over-time post-differentiation of dTHP-1 cells, particularly impacting pathways crucial for macrophage function. This finding is key for the interpretation of experimental results. These results highlight the need for standardized culture conditions in proteomic-based evaluations of treatment effects to ensure reliable results, a prerequisite for achieving regulatory acceptance of proteomics data.
Internal Nasal Valve Collapse Treatment by Endonasal Hyaluronic Acid Injection
Authors: Gagnieur Pierre , Fieux Maxime , Saloner Laurie , Louis Bruno , Vertu-Ciolino Delphine , Mojallal Alain-Ali 
Published: September 2024

Abstract
Objective
Internal nasal valve collapse (IVC) is a common functional complication of rhinoplasty and injecting hyaluronic acid is one of the treatment options available, but its effectiveness has never been evaluated. The objective of this study was to assess the evolution of IVC after injection of hyaluronic acid using objective and subjective measures of nasal obstruction.

Study Design
A prospective interventional study was conducted.

Methods
Adult patients consulting for nasal obstruction after (septo)rhinoplasty and diagnosed with IVC were included. Patients underwent 4-phase rhinomanometry, completed nasal obstruction symptoms evaluation (NOSE) and visual analog scale (VAS) questionnaires and received hyaluronic acid injections. Measurements were repeated immediately, one month and one year later. The primary outcome measure was the proportion of patients below the rhinomanometric diagnostic threshold for IVC at one month.

Results
Among the 22 patients included, 20 (91%) had rhinomanometry measurements below the diagnostic threshold for IVC one month after injection. It decreased to 53% (8/15 patients) at one year post injection. The mean NOSE score decreased from 74.5 (± 18.0) before injection to 35.2 (± 23.3) after injection (p < 0.0001). The mean VAS score decreased from 7.0 (± 1.4) before injection to 3.4 (± 1.9) after injection (p < 0.0001). In these patients with post-(septo)rhinoplasty IVC, hyaluronic acid injection into the internal nasal valve substantially improved subjective and objective measures of nasal obstruction.

Conclusion
These results suggest hyaluronic acid injection (performed as described) is an effective treatment for IVC and is an excellent alternative to surgical treatment.

Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors https://www.springer.com/00266.
MRI and active surveillance: thoughts from across the pond
Authors: Campbell Rebecca A. , Wood Andrew , Schwen Zeyad , Ward Ryan , Weight Christopher , Purysko Andrei S. 
Published: September 2024

Abstract
In the United States (US), urological guidelines recommend active surveillance (AS) for patients with low-risk prostate cancer (PCa) and endorse it as an option for those with favorable intermediate-risk PCa with a > 10-year life expectancy. Multiparametric magnetic resonance imaging (mpMRI) is being increasingly used in the screening, monitoring, and staging of PCa and involves the combination of T2-weighted, diffusion-weighted, and dynamic contrast-enhanced T1-weighted imaging.
The American Urological Association (AUA) guidelines provide recommendations about the use of mpMRI in the confirmatory setting for AS patients but do not discuss the timing of follow-up mpMRI in AS. The National Comprehensive Cancer Network (NCCN) discourages using it more frequently than every 12 months. Finally, guidelines state that mpMRI can be used to augment risk stratification but should not replace periodic surveillance biopsy.
In this review, we discuss the current literature regarding the use of mpMRI for patients with AS, with a particular focus on the approach in the US. Although AS shows a benefit to the addition of mpMRI to diagnostic, confirmatory, and follow-up biopsy, there is no strong evidence to suggest that mpMRI can safely replace biopsy for most patients and thus it must be incorporated into a multimodal approach.

Clinical relevance statement
According to the US guidelines, regular follow-ups are important for men with prostate cancer on active surveillance, and prostate MRI is a valuable tool that should be utilized, in combination with PSA kinetics and biopsies, for monitoring prostate cancer.

Key Points

According to the US guidelines, the addition of MRI improves the detection of clinically significant prostate cancer.

Timing interval imaging of patients on active surveillance remains unclear and has not been specifically addressed.

MRI should trigger further work-ups, but not replace periodic follow-up biopsies, in men on active surveillance.
Cost-efficient payoffs under model ambiguity
Authors: Bernard Carole , Junike Gero , Lux Thibaut , Vanduffel Steven 
Published: September 2024

AbstractDybvig (1988a, 1988b) solves in a complete market setting the problem of finding a payoff that is cheapest possible in reaching a given target distribution (“cost-efficient payoff”). In the presence of ambiguity, the distribution of a payoff is, however, no longer known with certainty. We study the problem of finding the cheapest possible payoff whose worst-case distribution stochastically dominates a given target distribution (“robust cost-efficient payoff”) and determine solutions under certain conditions. We study the link between “robust cost-efficiency” and the maxmin expected utility setting of Gilboa and Schmeidler (1989), as well as more generally in a possibly nonexpected robust utility setting. Specifically, we show that solutions to maxmin robust expected utility are necessarily robust cost-efficient. We illustrate our study with examples involving uncertainty both on the drift and on the volatility of the risky asset.