bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats
Authors: Chaumette T. , Chapuy E. , Berrocoso E. , Llorca‐Torralba M. , Bravo L. , Mico J.A. , Chalus M. , Eschalier A. , Ardid D. , Marchand F. , Sors A. 
Published: September 2017

AbstractBackgroundHistamine H3 receptors are mainly expressed on CNS neurons, particularly along the nociceptive pathways. The potential involvement of these receptors in pain processing has been suggested using H3 receptor inverse agonists.MethodsThe antinociceptive effect of S 38093, a novel inverse agonist of H3 receptors, has been evaluated in several neuropathic pain models in rat and compared with those of gabapentin and pregabalin.ResultsWhile S 38093 did not change vocalization thresholds to paw pressure in healthy rats, it exhibited a significant antihyperalgesic effect in the Streptozocin‐induced diabetic (STZ) neuropathy model after acute and chronic administration and, in the chronic constriction injury (CCI) model only after chronic administration, submitted to the paw‐pressure test. Acute S 38093 administration at all doses tested displayed a significant cold antiallodynic effect in a model of acute or repeated administration of oxaliplatin‐induced neuropathy submitted to cold tail immersion, cold allodynia being the main side effect of oxaliplatin in patients. The effect of S 38093 increased following chronic administration (i.e. twice a day during 5 days) in the CCI and STZ models except in the oxaliplatin models where its effect was already maximal from the first administration The kinetics and size of effect of S 38093 were similar to gabapentin and/or pregabalin. Finally, the antinociceptive effect of S 38093 could be partially mediated by α2 adrenoreceptors desensitization in the locus coeruleus.ConclusionsThese results highlight the interest of S 38093 to relieve neuropathic pain and warrant clinical trials especially in chemotherapeutic agent‐induced neuropathic pain.SignificanceS 38093, a new H3 antagonist/inverse agonist, displays antiallodynic and antihyperalgesic effect in neuropathic pain, especially in oxaliplatin‐induced neuropathy after chronic administration. This effect of S 38093 in neuropathic pain could be partly mediated by α2 receptors desensitization in the locus coeruleus.
Development of an Electrochemical Sensor Based on Covalent Molecular Imprinting for Selective Determination of Bisphenol‐A
Authors: Güney Sevgi , Güney Orhan 
Published: September 2017

AbstractIn this study, an electrochemical sensor was developed and used for selective determination of bisfenol‐A (BPA) by integrating sol‐gel technique and multi‐walled carbon nanotubes (MWCNTs) modified paste electrode. BPA bounded by covalently to isocyanatopropyl‐triethoxy silane (ICPTS) was synthesized as a new precursor (BPA‐ICPTS) and then BPA‐imprinted polymer (BPA‐IP) sol‐gel was prepared by using tetramethoxysilane (TMOS) and BPA‐ICPTS. Non‐imprinted polymer (NIP) sol‐gel was obtained by using TMOS and (3‐Aminopropyl) triethoxysilane. Both BPA‐IP and NIP sol‐gels were characterized by nitrogen adsorption‐desorption analysis, FTIR, SEM, particle size analyzer and optical microscope. Carbon paste sensor electrode was fabricated by mixing the newly synthesized BPA‐IP with MWCNTs, graphite powder and paraffin oil. The electrochemical characterization of the sensor electrode was achieved with cyclic and differential pulse voltammetric techniques. The response of the developed sensor under the most proper conditions was linear in BPA concentration range from 4.0×10−9 to 1.0×10−7 mol L−1 and 5.0×10−7 to 5.0×10−5 mol L−1 and the detection limit was 4.4×10−9 mol L−1. The results unclosed that the proposed sensor displayed high sensitivity and selectivity, superior electrochemical performance and rapid response to BPA.
Energy‐efficient multiperiod planning of optical core network to support 5G networks
Authors: Li Bingbing , Peng Limei , Hao Yixue , Miao Yiming , Hassan Mohammad Mehedi 
Published: September 2017

AbstractWith the rapid growth of traffic and power consumption in information and communication technology industry for decades, improving energy efficiency has become a challenging issue in recent years. Especially, the pervasive access to Internet via mobile devices will cause wireless traffic volume increment by 1000+ times in near future, which is expected to be carried by the fifth generation ultradense cellular network. Following this trend, the core network where optical fibers are deployed to deliver aggregated traffic needs upgrading to accommodate the increasing traffic volume. To match with the traffic growth rate, we should conduct efficient network planning over multiple time periods. Moreover, considering the heterogeneity in the bandwidth requirements among various network services, flexible mixed line rate scheme is adopted in network provisioning. In this paper, we study the long‐term multiperiod planning of optical core network by considering the traffic growth with the objective of high energy‐efficiency. Three planning strategies, say All‐period, Incremental, and End‐of‐Life, respectively, are studied and formulated as mixed integer linear programming models with the objective to minimize power consumption of optical core network. Given the estimation on the reduction of power consumed by various network devices, we can deploy network devices flexibly in each period through the optimization models. Performance of the proposed models is also evaluated and compared via case studies.
Motivation of the nurses in pre‐hospital emergency and educational hospitals emergency in the southeast of Iran
Authors: Sheikhbardsiri Hojjat , Khademipour Gholamreza , Nekoei‐Moghadam Mahmoud , Aminizadeh Mohsen 
Published: September 2017

SummaryIntroductionNurses, as the largest human resource element of health care systems, have a major role in providing ongoing, high‐quality care to patients. Therefore, due to the importance of this issue, this study aimed to determine job motivation of the nurses in pre‐hospital and educational hospitals emergency in the southeast of Iran.MethodsIn this study, a cross‐sectional method was used, and it was conducted in educational hospitals and pre‐hospital emergencies under supervision of the Kerman University of Medical Sciences in 2017. Using a valid and reliable questionnaire, we assessed job motivation of the nurses using a census method (N = 275). Data were analyzed by implementing descriptive statistics including mean and standard deviation (SD), and analytical statistics such as Kolmogorov‐Smirnov, ANOVA, t‐test, X2, Pearson, and multivariate regression tests using SPSS 16 and P ≤ 0.05.ResultsAmong the pre‐hospital emergency nurses, the average of the educational factors was 25.33, financial factors was 6.34, psychological factors was 20.07, welfare factors was 0.63, and administrative factors was 8.16. Among the nurses of the educational hospitals emergency, these factors were 25.33, 6.51, 20.34, 16.55, and 8.39, respectively. Two group's nurses were at the intermediate level of the job motivation.ConclusionDynamic and predetermined goals of emergency include providing services as soon as possible and stabilizing patient's condition during the golden and vital time of rescue. Findings suggest that national and local policies in Iran may need to examine factors that contribute to the promotion of the motivation as well as focusing on how to improve them.
Biocompatibility assessment of cyclic olefin copolymers: Impact of two additives on cytotoxicity, oxidative stress, inflammatory reactions, and hemocompatibility
Authors: Bernard Mélisande , Jubeli Emile , Bakar Joudi , Tortolano Lionel , Saunier Johanna , Yagoubi Najet 
Published: September 2017

AbstractThis work reports the biocompatibility evaluation of cyclic olefin copolymers (COC) as candidates for implantable medical devices. The focus was to establish the influence of two major additives (antioxidant and lubricant) on the overall biocompatibility.The cytotoxicity was evaluated according to ISO 10993‐5 guidelines using L929 fibroblasts, HUVEC, and THP‐1‐derived macrophages. Oxidative stress (ROS, GSH/GSSG, and SOD analysis) and pro‐inflammatory cytokines (Il‐6 and TNF‐α secretion) were quantified using THP‐1 cells in direct contact with films. Hemocompatibility was assessed through haemolysis testing, dynamic blood coagulation, platelet adhesion, and activation (membranous P‐selectin expression).Results show that the different types of COC have successfully passed the in vitro biocompatibility tests. The presence of antioxidant induces however a slight decrease in ROS production in correlation with a high SOD activity and a modification in blood coagulation profile probably linked to antioxidant recrystallization phenomenon on the surface of COC. The lubricant presence reduced haemolysis, fibrinogen adhesion, and platelet activation.Surface nanotopography of COC highlights different types of needles and globules according to the present additive. Those primary results indicate that COC are promising biomaterial. However, additives influenced some biological parameters pointing out the necessity of a global approach of risk analysis for biocompatibility evaluation. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3333–3349, 2017.
Dominating induced matchings in graphs containing no long claw
Authors: Hertz Alain , Lozin Vadim , Ries Bernard , Zamaraev Viktor , de Werra Dominique 
Published: September 2017

AbstractAn induced matching M in a graph G is dominating if every edge not in M shares exactly one vertex with an edge in M. The dominating induced matching problem (also known as efficient edge domination) asks whether a graph G contains a dominating induced matching. This problem is generally NP‐complete, but polynomial‐time solvable for graphs with some special properties. In particular, it is solvable in polynomial time for claw‐free graphs. In the present article, we provide a polynomial‐time algorithm to solve the dominating induced matching problem for graphs containing no long claw, that is, no induced subgraph obtained from the claw by subdividing each of its edges exactly once.
Infinitely many planar cubic hypohamiltonian graphs of girth 5
Authors: Goedgebeur Jan , Zamfirescu Carol T. 
Published: September 2017

AbstractA graph G is hypohamiltonian if G is non‐hamiltonian and for every vertex v in G, the graph is hamiltonian. McKay asked in [J. Graph Theory 85 (2017) 7–11] whether infinitely many planar cubic hypohamiltonian graphs of girth 5 exist. We settle this question affirmatively.
Oxaliplatin‐induced increase in splenic volume; irreversible change after adjuvant FOLFOX
Authors: Iwai Takuma , Yamada Takeshi , Koizumi Michihiro , Shinji Seiichi , Yokoyama Yasuyuki , Takahashi Goro , Takeda Kohki , Hara Keisuke , Ohta Keiichiro , Uchida Eiji 
Published: September 2017

Background and ObjectivesOxaliplatin can cause hepatic sinusoidal obstruction syndrome (SOS). SOS can cause chemotherapy‐related adverse effects or morbidity after liver resection. Conventionally, SOS is diagnosed using liver biopsy. Recently, it was reported that increased splenic volume (SV) can be used to detect SOS. In this study, we evaluated the changes in SV during adjuvant chemotherapy.MethodsWe enrolled 103 consecutive patients with stage III and high‐risk stage II colorectal cancer treated with mFOLFOX6 (n = 37) or oral fluorouracil and leucovorin (n = 66) after curative surgery. SV was measured three times; pre‐operatively, after chemotherapy, and 1 year after chemotherapy.ResultsSV was higher after mFOLFOX6 (median 135.89 mL) than pre‐operatively (105.75 mL) (P < 0.001); SV at 1‐year after finishing mFOLFOX6 (114.16 mL) returned to the same level as before surgery (P = 0.0015). SV increased in 28 patients (75.7%) treated with mFOLFOX6 (95%CI, 61.8‐89.5), but had not recovered in 12 of these cases (42.9%) 1 year after finishing treatment (95%CI, 17.3‐47.5). In contrast, oral fluorouracil and leucovorin did not change SV.ConclusionsSV increased after adjuvant mFOLFOX6, and had not recovered in almost half of cases 1‐year after finishing chemotherapy. This increase may indicate continuous SOS, which can adversely affect treatment after recurrence.
Ionic Liquid Approach Toward Manufacture and Full Recycling of All‐Cellulose Composites
Authors: Spörl Johanna M. , Batti Fabio , Vocht Marc‐Phillip , Raab Raphael , Müller Alexandra , Hermanutz Frank , Buchmeiser Michael R. 
Published: September 2017

AbstractAll‐cellulose composites (ACCs) are prepared from high‐strength rayon fibers and cellulose pulp. The procedure comprises the use of a pulp cellulose solution in the ionic liquid (IL) 1‐ethyl‐3‐methyl imidazolium acetate ([EMIM][OAc]) as a precursor for the matrix component. High‐strength rayon fibers/fabrics are embedded in this solution of cellulose in the IL followed by removal of the IL. Different concentrations of cellulose in the IL are investigated and the mechanical properties of the final ACCs are determined via tensile, bending, and impact testing. ACCs prepared in this study show mechanical properties comparable to thermoplastic glass fiber‐reinforced plastics. Apart from being bio‐based, they possess several advantages such as biodegradability and full recyclability. The recycling of ACCs is successfully demonstrated in several cycles by using the recycled cellulose for subsequent matrix preparation.
Multiplicity results for a class of quasilinear equations with exponential critical growth
Authors: Alves Claudianor O. , de Freitas Luciana R. 
Published: September 2017

AbstractIn this work, we prove the existence and multiplicity of positive solutions for the following class of quasilinear elliptic equations:
urn:x-wiley:0025584X:media:mana201500371:mana201500371-math-0001where is the N‐Laplacian operator, , f is a function with exponential critical growth, μ and ε are positive parameters and A is a nonnegative continuous function verifying some hypotheses. To obtain our results, we combine variational arguments and Lusternik–Schnirelman category theory.
Analysis on the local structures for 3d1 impurities (Ti3+ and V4+) in KTiPO4
Authors: Ding C.C. , Wu S.Y. , Zhang L.J. , Xu Y.Q. , Zhang Z.H. , Wu M.H. , Teng B.H. 
Published: September 2017

Making use of the perturbation formulae for 3d1 ions (Ti3+ and V4+) under orthorhombically compressed octahedra, the spin Hamiltonian parameters (g factors: gx, gy, gz and hyperfine structure constants: Ax, Ay, Az) and local structures of the 3d1 impurity centres C1, C2, and C3 in KTiOPO4 crystals are theoretically analyzed in a consistent way. The remarkable local distortions (i.e., the relative axial compression ratios 11.2%, 7.0%, and 5.5% along Z axis and the relative planar bond length variation ratios 15.9%, 7.0%, and 6.0%) are obtained for the [Ti2O6]9− cluster on Ti2 site and [VO6]8− clusters on Ti1 and Ti2 sites, respectively, in view of the Jahn–Teller effect. The above local orthorhombic distortion parameters in the impurity centres are found to be more significant than the host Ti1 and Ti2 sites in pure KTiOPO4. The sequences (C1 > C2 > C3) of the local orthorhombic distortion parameters ρ and τ are in accordance with those of the axial and perpendicular anisotropies Δg and δg of g factors, respectively.
Genetic modifiers of Duchenne and facioscapulohumeral muscular dystrophies
Authors: Hightower Rylie M. , Alexander Matthew S. 
Published: September 2017

ABSTRACTMuscular dystrophy is defined as the progressive wasting of skeletal muscles that is caused by inherited or spontaneous genetic mutations. Next‐generation sequencing has greatly improved the accuracy and speed of diagnosis for different types of muscular dystrophy. Advancements in depth of coverage, convenience, and overall reduced cost have led to the identification of genetic modifiers that are responsible for phenotypic variability in affected patients. These genetic modifiers have been postulated to explain key differences in disease phenotypes, including age of loss of ambulation, steroid responsiveness, and the presence or absence of cardiac defects in patients with the same form of muscular dystrophy. This review highlights recent findings on genetic modifiers of Duchenne and facioscapulohumeral muscular dystrophies based on animal and clinical studies. These genetic modifiers hold great promise to be developed into novel therapeutic targets for the treatment of muscular dystrophies. Muscle Nerve 57: 6–15, 2018
In vivo assessment of muscle membrane properties in the sodium channel myotonias
Authors: Tan S. Veronica , Z'Graggen Werner J. , Hanna Michael G. , Bostock Hugh 
Published: September 2017

ABSTRACTIntroductionThe gain‐of‐function mutations that underlie sodium channel myotonia (SCM) and paramyotonia congenital (PMC) produce differing clinical phenotypes. We used muscle velocity recovery cycles (MVRCs) to investigate membrane properties.MethodsMVRCs and responses to trains of stimuli were compared in patients with SCM (n = 9), PMC (n = 8), and normal controls (n = 26).ResultsThe muscle relative refractory period was reduced in SCM, consistent with faster recovery of the mutant sodium channels from inactivation. Both SCM and PMC showed an increased early supernormality and increased mean supernormality following multiple conditioning stimuli, consistent with slowed sodium channel inactivation. Trains of fast impulses caused a loss of amplitude in PMC, after which only half of the muscle fibers recovered, suggesting that the remainder stayed depolarized by persistent sodium currents.DiscussionThe differing effects of mutations on sodium channel function can be demonstrated in human subjects in vivo using this technique. Muscle Nerve 57: 586–594, 2018
Sonoanatomy of sensory branches of the ulnar nerve below the elbow in healthy subjects
Authors: Kim Ki Hoon , Lee Seok Jun , Park Byung Kyu , Kim Dong Hwee 
Published: September 2017

ABSTRACTIntroductionWe identify sensory branches of the ulnar nerve—palmar ulnar cutaneous nerve (PUCN), dorsal ulnar cutaneous nerve (DUCN), and superficial sensory branch—using ultrasonography.MethodsIn 60 forearms of 30 healthy adult volunteers, the origin and size of the PUCN, DUCN, and superficial sensory branch were measured by ultrasonography. The relative pathway of the DUCN to the ulnar styloid process was also investigated.ResultsThe PUCN was observed in 47 forearms (78%), and the DUCN was observed in all forearms. Average distances from the pisiform to the origin of the PUCN and DUCN were 11.9 ± 1.4 and 7.0 ± 1.0 cm, respectively. Superficial and deep divisions split 0.9 ± 0.3 cm distal to the pisiform. Cross‐sectional areas of the PUCN, DUCN, and superficial sensory branch were 0.3 ± 0.1, 1.5 ± 0.5, and 3.9 ± 1.0 mm2, respectively.DiscussionSensory branches of the ulnar nerve can be visualized by ultrasonography, helping to differentiate ulnar nerve injury originating at either wrist or elbow. Muscle Nerve 57: 569–573, 2018
β‐Deuterium Isotope Effects on Firefly Luciferase Bioluminescence
Authors: Pirrung Michael C. , Dorsey Allyson , Howitt Natalie De , Liao Jiayu 
Published: September 2017

AbstractA 5,5‐d2‐luciferin was prepared to measure isotope effects on reactions of two intermediates in firefly bioluminescence: emission by oxyluciferin and elimination of a putative luciferyl adenylate hydroperoxide to dehydroluciferin. A negligible isotope effect on bioluminescence provides further support for the belief that the emitting species is the keto‐phenolate of oxyluciferin and rules out its excited‐state tautomerization, one potential contribution to a bioluminescence quantum yield less than unity. A small isotope effect on dehydroluciferin formation supports a single‐electron‐transfer mechanism for reaction of the luciferyl adenylate enolate with oxygen to form the hydroperoxide or dehydroluciferin. Partitioning between the dioxetanone intermediate (en route to oxyluciferin) and dehydroluciferin is determined, not by the fate of the hydroperoxide, but by that of the radical formed from luciferyl adenylate, and the kinetic isotope effect (KIE) reflects H‐atom abstraction by superoxide.
Treatment of plasminogen deficiency patients with fresh frozen plasma
Authors: Kızılocak Hande , Ozdemir Nihal , Dikme Gürcan , Koç Begüm , Atabek Ayşe Ayzıt , Çokuğraş Haluk , İskeleli Güzin , Dönmez‐Demir Buket , Christiansen Nina Merete , Ziegler Maike , Ozdağ Hilal , Schuster Volker , Celkan Tiraje 
Published: September 2017

AbstractCongenital plasminogen (Plg) deficiency leads to the development of ligneous membranes on mucosal surfaces. Here, we report our experience with local and intravenous fresh frozen plasma (FFP). We retrospectively reviewed medical files of 17 patients and their eight first‐degree relatives. Conjunctivitis was the main complaint. Thirteen patients were treated both with intravenous and conjunctival FFP. Venous thrombosis did not develop in any. Genetic evaluation revealed heterogeneous mutations as well as polymorphisms. Diagnosis and treatment of Plg deficiency is challenging; topical and intravenous FFP may be an alternative treatment.
High strength reversible adhesive closures
Authors: King Daniel R. , Bartlett Michael D. , Nalbach Martin , Irschick Duncan J. , Crosby Alfred J. 
Published: September 2017

ABSTRACTClosures such as buttons, clasps, zippers, and hook‐and‐loops find widespread use in daily life, and all work by mechanical interlocking. However, these traditional closures are often rigid, lose performance with age, and can produce a harsh sound during use. Here high strength (>50 N cm−2), reusable, and nearly silent closure devices are fabricated based on recently developed fibril‐less gecko‐inspired adhesives. Guided by a reversible adhesion scaling law, the closure force capacity is tuned by modifying the closure materials and geometry. A simple analytical model is presented which accurately predicts system performance, based on the reversible adhesion scaling parameter. The force capacity of these adhesive closures is measured and compared to commercially‐available hook‐and‐loop closures, and it is found that the adhesive closures sustain forces that are 4.4 times greater for comparable geometry. The sound of release is also quantified and shown to be minimal for adhesive closures. This work provides motivation to develop new high strength, reusable closures for commercial and industrial applications. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2017, 55, 1783–1790