bluuebunny/crossref_metadata_2025_split huggingface dataset:
The contribution of dietary composition over 25 years to cardiovascular risk factors in childhood and adulthood: the Princeton Lipid Research Study
Authors: Beck Leah C. , Woo Jessica G. 
Published: October 2024

AbstractDiet is a contributing factor to CVD risk, but how diet quality changes over the long term and contributes to CVD risk is less well studied. Diet data were analysed from parents and offspring from the Princeton Lipid Research Study (24-h recall in the 1970s; Block FFQ in 1998). Diet quality was assessed using an 8-point Dietary Approaches to Stop Hypertension nutrient-based scoring index, including a new method for scoring in children, as well as examining twelve key macro/micronutrients. Outcomes included blood glucose, blood pressure, serum lipids and BMI. The analysis included 221 parents (39 % male, mean age 38·9 ± 6·5 at baseline and 66·6 ± 6·6 at follow-up) and 606 offspring (45 % male, 11·9 ± 3·2 at baseline and 38·5 ± 3·6 at follow-up). Parents’ Dietary Approaches to Stop Hypertension score increased slightly from baseline to follow-up (1·4 ± 1·0 and 2·1 ± 1·3, respectively, P < 0·001), while offspring remained consistent (1·6 ± 0·9 and 1·6 ± 1·1, respectively, P = 0·58). Overall, the Dietary Approaches to Stop Hypertension score, adjusted for age, race, sex and BMI, was not significantly associated with any examined outcomes. Of the macro/micronutrients at follow-up, saturated and total fat were associated with increased diabetes and dyslipidaemia in parents, while the inverse was seen with niacin. Among offspring, niacin was associated with lower rates of hypertension and dyslipidaemia. In conclusion, no relationship was detected between Dietary Approaches to Stop Hypertension adherence and disease outcomes. However, both saturated fat and niacin were associated with components of CVD risk, highlighting the need for improved diet quality overall.
Law and Sufism in modern South Asia: A changing relationship
Authors: Zaman Muhammad Qasim 
Published: October 2024

AbstractThis article studies some major shifts in the relationship between law and Sufism in South Asian Islam between the eighteenth and the twentieth centuries. It does so by focusing on Shah Wali Allah of Delhi (d. 1762) to examine, first, how these two key facets of Islam interact with each other in his thought and, second, how some influential Muslim intellectuals of the late nineteenth and twentieth centuries have understood and positioned themselves in relation to this aspect of his thought. Though one would be hard pressed to know this from the sanitized modern image of Wali Allah as a scholar of the Quran and hadith, and of a Sufi piety uncompromisingly anchored in them, his Sufism reveals a wide and, from many a modern Muslim perspective, unwieldly range of ideas and practices. Yet it was precisely in that unwieldy breadth and depth that it was generative of some of his key insights into matters of the law. Even as many people have continued to insist on the imbrication of law and Sufism, a sanitization of Wali Allah’s Sufi image serves to highlight wider processes whereby an earlier era’s generative relationship between the two has come to be increasingly attenuated since the late nineteenth century.
First camera-trap evidence of the Critically Endangered Chinese pangolin Manis pentadactyla in Kavrepalanchok community forests, Nepal
Authors: Shrestha Nischal , Pandey Sadip Raj , Shrestha Sandeep , Bashyal Ashish 
Published: October 2024

Abstract
The Chinese pangolin Manis pentadactyla is categorized as Critically Endangered on the IUCN Red List but little is known about its status in Nepal. Although indirect sign surveys have reported its presence in several community forests in Kavrepalanchok district, no photographic or video evidence has previously been documented. We used camera traps to investigate the occurrence of pangolins in 20 community forests in Panauti Municipality in Kavrepalanchok. A total of 75 0.01 km2 plots were surveyed using camera traps during September 2022–February 2023, with a total survey effort of 803 trap-days. The cameras recorded a total of 16 individual video footage events of Chinese pangolins in six of the community forests. This is the first camera-trap evidence of the species' presence in these forest patches, and in Kavrepalanchok district. The pangolins displayed behaviours such as sniffing, gathering plant material and digging, between 18.00 and 1.00. The camera-trap records provide more accurate species identification and reliable information than indirect sign surveys, indicating camera traps are a useful surveying tool for rare, nocturnal and elusive pangolins.
Mendelian randomization analysis of maternal coffee consumption during pregnancy on offspring neurodevelopmental difficulties in the Norwegian Mother, Father and Child Cohort Study (MoBa)
Authors: D'Urso Shannon , Wootton Robyn E , Ask Helga , Brito Nunes Caroline , Andreassen Ole A , Hwang Liang-Dar , Moen Gunn-Helen , Evans David M , Havdahl Alexandra 
Published: October 2024

AbstractBackgroundPrevious observational epidemiological studies have suggested that coffee consumption during pregnancy may affect fetal neurodevelopment. However, results are inconsistent and may represent correlational rather than causal relationships. The present study investigated whether maternal coffee consumption was observationally associated and causally related to offspring childhood neurodevelopmental difficulties (NDs) in the Norwegian Mother, Father and Child Cohort Study.MethodsThe observational relationships between maternal/paternal coffee consumption (before and during pregnancy) and offspring NDs were assessed using linear regression analyses (N = 58694 mother-child duos; N = 22 576 father-child duos). To investigate potential causal relationships, individual-level (N = 46 245 mother-child duos) and two-sample Mendelian randomization (MR) analyses were conducted using genetic variants previously associated with coffee consumption as instrumental variables.ResultsWe observed positive associations between maternal coffee consumption and offspring difficulties with social-communication/behavioral flexibility, and inattention/hyperactive-impulsive behavior (multiple testing corrected p < 0.005). Paternal coffee consumption (negative control) was not observationally associated with the outcomes. After adjusting for potential confounders (smoking, alcohol, education and income), the maternal associations attenuated to the null. MR analyses suggested that increased maternal coffee consumption was causally associated with social-communication difficulties (individual-level: beta = 0.128, se = 0.043, p = 0.003; two-sample: beta = 0.348, se = 0.141, p = 0.010). However, individual-level MR analyses that modelled potential pleiotropic pathways found the effect diminished (beta = 0.088, se = 0.049, p = 0.071). Individual-level MR analyses yielded similar estimates (heterogeneity p = 0.619) for the causal effect of coffee consumption on social communication difficulties in maternal coffee consumers (beta = 0.153, se = 0.071, p = 0.032) and non-consumers (beta = 0.107, se = 0.134, p = 0.424).ConclusionsTogether, our results provide little evidence for a causal effect of maternal coffee consumption on offspring NDs.
Contract as Vow or Oath
Authors: Leib Ethan J. 
Published: October 2024

AbstractMany scholars and judges attempt to harmonize legal practices of contracting with the social practice of promising in ordinary life. This article explores an alternative genealogy of contract in traditional social practices that track many of contract's core norms: taking vows and oaths. Without denying that promissory morality infiltrates modern contract, contract-as-vow-or-oath can expose by way of a supplementary account why some contract rules work as they do and can take some pressure off of a more unitary promissory theory in justifying, explicating, and reforming contract law.
What do health professionals think about implementing psilocybin-assisted therapy in palliative care for existential distress? A World Café qualitative study
Authors: Masse-Grenier Marianne , Chang Sue-Ling , Bélanger Ariane , Stephan Jean-François , Hébert Johanne , Deschamps Pierre , Plourde Louis , Provost François , Farzin Houman , Fallu Jean-Sébastien , Dorval Michel ,   P3A Research Group
Published: October 2024

AbstractObjectivesPromising studies show that psilocybin-assisted therapy relieves existential distress in patients with serious illnesses, a difficult condition to treat with current treatment options. There is growing interest in this therapy in palliative care. Canada recently amended its laws to allow physicians to request psilocybin for end-of-life distress. However, barriers to access remain. Since implementing psilocybin-assisted therapy within palliative care depends on the attitudes of healthcare providers willing to recommend it, they should be actively engaged in the broader discussion about this treatment option. We aimed (1) to identify issues and concerns regarding the acceptability of this therapy among palliative care professionals and to discuss ways of remedying them and (2) to identify factors that may facilitate access.MethodsA qualitative study design and World Café methodology were adopted to collect data. The event was held on April 24, 2023, with 16 palliative care professionals. The data was analyzed following an inductive approach.ResultsAlthough participants were interested in psilocybin-assisted therapy, several concerns and needs were identified. Educational and certified training needs, medical legalization of psilocybin, more research, refinement of therapy protocols, reflections on the type of professionals dispensing the therapy, the treatment venue, and eligibility criteria for treatment were discussed.Significance of resultsPalliative care professionals consider psilocybin-assisted therapy a treatment of interest, but it generates several concerns. According to our results, the acceptability of the therapy and the expansion of its access seem interrelated. The development of guidelines will be essential to encourage wider therapy deployment.
Thermodynamic and Dynamic Variations in Sea Ice Thickness of the Ross Sea, Antarctica, Driven by Atmospheric Circulation
Authors: Koo Younghyun , Xie Hongjie , Ackley Stephen F. 
Published: October 2024

AbstractAtmospheric circulation has significant impacts on sea ice drifting patterns and mass balance, as wind drag induces pressure ridges and leads on the sea ice surface. In this study, the spatiotemporal distributions of these dynamic sea ice deformation features in the Ross Sea are examined using ICESat‐2 (IS2) ATL10 freeboard data (2019–2022). The temporal variation of the modal sea ice thickness (SIT), caused by thermodynamic ice growth and sea ice advection, varies from 0.7–1.0 m in April to 1.0–1.6 m in July–September and decreases thereafter in the northwest (NW) and northeast (NE) sectors. This temporal variation of modal SIT agrees with the air temperature (correlation coefficients >0.5). The southwest (SW) sector shows a consistently low modal SIT (<1.0 m) because of the production of new ice in polynyas and continuous northward sea ice drift. Meanwhile, the southeast (SE) sector shows the thickest ice in Octobers 2019 and 2020 because of the advection of thick ice from the Amundsen Sea, which was reduced in 2021 and 2022. In terms of dynamic sea ice deformation, the SE sector shows the largest deformation because of the wind‐driven convergence of sea ice movement. However, such intense deformation in the SE sector diminished in 2021 and 2022 due to the dominance of strong southerly wind associated with the Amundsen Sea Low (ASL). This study emphasizes the potential of IS2 sea ice products to assess the role of atmospheric driving forces on thermodynamic and dynamic sea ice changes.
A Bayesian Model for 20th Century Antarctic Sea Ice Extent Reconstruction
Authors: Maierhofer T. J. , Raphael M. N. , Fogt R. L. , Handcock M. S. 
Published: October 2024

AbstractAntarctic sea ice, a key component in the complex Antarctic climate system, is an important driver and indicator of the global climate. In the relatively short satellite‐observed period from 1979 to 2022 the sea ice extent has continuously increased (contrasting a major decrease in Arctic sea ice) up to a dramatic decrease between 2014 and 2017. Recent years have seen record sea ice lows in February 2022–February 2023. We use a statistical ensemble reconstruction of Antarctic sea ice to put the observed changes into the historical context of the entire 20th century. We propose a seasonal Vector Auto‐Regressive Moving Average (VARMA) model fit in a Bayesian framework using regularized horseshoe priors on the regression coefficients to create a stochastic ensemble reconstruction of monthly Antarctic Sea ice extent from 1900 to 1979. This novel model produces a set of 2,500 plausible sea ice extent reconstructions for the sea ice by sector that incorporate the autocorrelation structure of sea ice over time as well as the dependence of sea ice between the sectors. These fully observed reconstructions exhibit plausible month‐to‐month changes in reconstructed sea ice as well as plausible interactions between the sectors and the total. We reconstruct an overall higher sea ice extent earlier in the 20th century with a relatively sharp decline in the 1970s. These trends agree well with previous reconstructions of Antarctic sea ice based on ice core data, whaling locations, and climatological data, as well as early satellite observations in the reconstruction period.
Spatial and Temporal Patterns of Maize Phenology in China From 2001 to 2020
Authors: Peng Qiongyan , Shen Ruoque , Liu Yujie , Li Xiangqian , Sun Qingling , Huang Jianxi , Yuan Wenping 
Published: October 2024

AbstractClimate change has significantly altered crop phenology, which has further impacted crop growth and yield. Accurate monitoring of crop phenology is essential for managing agricultural production in response. However, regional monitoring requires high spatial resolution distribution data, as medium resolution data suffers from mixed pixel issues. This study based on a long‐term high spatiotemporal resolution fusion data set of Normalized Difference Vegetation Index and an annually updated maize distribution data set, used the relative threshold method to identify the maize phenology in 22 provinces of China from 2001 to 2020. We further analyzed the trend of maize phenology and assessed its responses to climate change. The results reveal large inter‐annual fluctuations and spatial variability in maize phenology from 2001 to 2020. The length of the growth season (LOS) of spring maize has prolonged by 4.28 days in the northern maize zone and has shortened by 4.90 days in the southern maize zone. Additionally, the LOS of summer maize in the Huang‐Huai‐Hai region has shortened by 2.24 days. We also found a positive correlation between the length of the vegetative growth stage and the mean temperature and a negative correlation between the length of the reproductive growth stage and accumulated precipitation. This study utilized large‐scale, high‐resolution maize phenology data to analyze the trend of maize phenology and its response to climate change. These findings are expected to provide valuable support for assessing maize growth status and developing agricultural adaptive practices.
Real-time ultrasound to assess the umbilical catheter position in neonates: a randomized, controlled trial
Authors: Ponin Lalita , Ruangkit Chayatat , Ruangwattanapaisarn Nichanan , Nuntnarumit Pracha 
Published: October 2024

Abstract

Objective
To compare real-time ultrasound (RT-US) use as an adjunct tool to verify umbilical catheter placement versus standard care without ultrasound.

Study design
Neonates requiring umbilical venous catheter (UVC) and umbilical artery catheter (UAC) placement were randomized into the standard formula (No-US) and the RT-US groups. X-rays were used to confirm the catheter position.

Result
Fifty and forty-nine neonates were in the RT-US and No-US groups, respectively. RT- US showed a significantly higher rate of initial X-ray-confirmed proper catheter position than No-US (p < 0.001). The rates of proper positions of UVCs and UACs were significantly higher in the RT-US group than in the No-US group (both p < 0.001). Neonates in the RT-US group required fewer catheter adjustments and subsequent X-rays than those in the No-US group.

Conclusion
RT-US enhances the accuracy of UVC and UAC placement, reduces catheter adjustments, and the number of X-rays required.

Trial registration
TCTR20190622001
Metabolomic profiling reveals the step-wise alteration of bile acid metabolism in patients with diabetic kidney disease
Authors: Zhang Qing , Lu Liqian , Wang Jiao , Lu Manman , Liu Dongwei , Zhou Chunyu , Liu Zhangsuo 
Published: October 2024

Abstract
Background
Diabetic kidney disease (DKD) is the major complication of diabetes concomitant with gut dysbiosis and glycometabolic disorder, which are strongly associated with bile acid (BA) metabolism. Yet studies investigating the BA metabolism involving in DKD pathogenesis are limited. This study aimed to explore the metabolomic profiling of BAs in DKD and analyze its association with DKD progression.

Methods
An ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was established to quantify BAs in the plasma, fecal and urine samples of patients with DKD or T2DM and healthy individuals (n = 30 for each group). The key BAs associated with DKD were identified by orthogonal partial least-squares discriminant analysis (OPLS-DA) and receiver-operating characteristic (ROC) curve. Polynomial regression and Pearson’s correlation analyses were performed to assess the correlation between the key BAs and the clinical indicators reflecting DKD progression.

Results
Metabolomic profiling of 50 kinds of BAs presented the markedly step-wise alterations of BAs in plasma and feces as well as the little in urine of patients with DKD. Eight kinds of BAs in the plasma, eight kinds in the feces and three kinds in the urine were abnormally expressed, accompanying with the increased conjugated/unconjugated ratios of cholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid and hyocholic acid in the plasma, and of cholic acid, chenodeoxycholic acid and lithocholic acid in the feces. Moreover, the increased plasma level of glycochenodeoxycholic acid, and the increased fecal levels of glycolithocholic acid, 7-ketodeoxycholic acid and chenodeoxycholic acid-3-β-D-glucuronide are strongly correlated with the clinical indicators reflecting DKD progression, including eGFR, 24 h urinary protein and 24 h urinary microalbumin.

Conclusions
Our study for the first time disclosed the specific alterations of BA metabolism reflecting the step-wise progression of DKD, providing the basis for early identification and therapeutical strategies for DKD.
Healthy ageing and oral health: priority, policy and public health
Authors: Patel Rakhee , Gallagher Jennifer E. 
Published: October 2024

AbstractThe global population ageing, and the pace of ageing is accelerating. Although people are living longer, these additional years are not being gained in health, and disability, chronic and long-term conditions increase with age. In response to the challenges of an ageing population, the United Nations and World Health Organisation declared 2021–2030 the Decade of Healthy Ageing, with the purpose of collaborative action to foster longer and healthier lives. This review explores the WHO public health framework for healthy ageing and global trends and policies, using the UK as an example of policy implementation. In response to the urgent need to consider the impact of ageing on oral health and oral healthcare systems, an integrated model for healthy ageing and oral health is proposed.
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis
Authors: Ofoghi Anahita , Kotschi Stefan , Lemmer Imke L. , Haas Daniel T. , Willemsen Nienke , Bayer Batoul , Jung Anna S. , Möller Sophie , Haberecht-Müller Stefanie , Krüger Elke , Krahmer Natalie , Bartelt Alexander 
Published: October 2024

AbstractFerroptosis is an iron-dependent, non-apoptotic form of cell death initiated by oxidative stress and lipid peroxidation. Recent evidence has linked ferroptosis to the action of the transcription factor Nuclear factor erythroid-2 derived,-like-1 (NFE2L1). NFE2L1 regulates proteasome abundance in an adaptive fashion, maintaining protein quality control to secure cellular homeostasis, but the regulation of NFE2L1 during ferroptosis and the role of the ubiquitin-proteasome system (UPS) herein are still unclear. In the present study, using an unbiased proteomic approach charting the specific ubiquitylation sites, we show that induction of ferroptosis leads to recalibration of the UPS. RSL3-induced ferroptosis inhibits proteasome activity and leads to global hyperubiquitylation, which is linked to NFE2L1 activation. As NFE2L1 resides in the endoplasmic reticulum tethered to the membrane, it undergoes complex posttranslational modification steps to become active and induce the expression of proteasome subunit genes. We show that proteolytic cleavage of NFE2L1 by the aspartyl protease DNA-damage inducible 1 homolog 2 (DDI2) is a critical step for the ferroptosis-induced feed-back loop of proteasome function. Cells lacking DDI2 cannot activate NFE2L1 in response to RSL3 and show global hyperubiquitylation. Genetic or chemical induction of ferroptosis in cells with a disrupted DDI2-NFE2L1 pathway diminishes proteasomal activity and promotes cell death. Also, treating cells with the clinical drug nelfinavir, which inhibits DDI2, sensitized cells to ferroptosis. In conclusion, our results provide new insight into the importance of the UPS in ferroptosis and highlight the role of the DDI2-NFE2L1 as a potential therapeutic target. Manipulating DDI2-NFE2L1 activity through chemical inhibition might help sensitizing cells to ferroptosis, thus enhancing existing cancer therapies.
Tumour-informed liquid biopsies to monitor advanced melanoma patients under immune checkpoint inhibition
Authors: Schroeder Christopher , Gatidis Sergios , Kelemen Olga , Schütz Leon , Bonzheim Irina , Muyas Francesc , Martus Peter , Admard Jakob , Armeanu-Ebinger Sorin , Gückel Brigitte , Küstner Thomas , Garbe Claus , Flatz Lukas , Pfannenberg Christina , Ossowski Stephan , Forschner Andrea 
Published: October 2024

AbstractImmune checkpoint inhibitors (ICI) have significantly improved overall survival in melanoma patients. However, 60% experience severe adverse events and early response markers are lacking. Circulating tumour DNA (ctDNA) is a promising biomarker for treatment-response and recurrence detection. The prospective PET/LIT study included 104 patients with palliative combined or adjuvant ICI. Tumour-informed sequencing panels to monitor 30 patient-specific variants were designed and 321 liquid biopsies of 87 patients sequenced. Mean sequencing depth after deduplication using UMIs was 6000x and the error rate of UMI-corrected reads was 2.47×10−4. Variant allele fractions correlated with PET/CT MTV (rho=0.69), S100 (rho=0.72), and LDH (rho=0.54). A decrease of allele fractions between T1 and T2 was associated with improved PFS and OS in the palliative cohort (p = 0.008 and p < 0.001). ctDNA was detected in 76.9% of adjuvant patients with relapse (n = 10/13), while all patients without progression (n = 9) remained ctDNA negative. Tumour-informed liquid biopsies are a reliable tool for monitoring treatment response and early relapse in melanoma patients with ICI.