bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions
Authors: Pittala Valeria , Vanella Luca , Salerno Loredana , Romeo Giuseppe , Marrazzo Agostino , Di Giacomo Claudia , Sorrenti Valeria 
Published: June 2017

Background:
The aim of this review is to summarize the effects of various naturally
occurring polyphenols in the management of metabolic dysfunctions. This cluster of metabolic
abnormalities comprises insulin resistance, increased levels of free fatty acids, hypercholesterolemia,
obesity, hyperglycemia and hypertension, diabetes mellitus (DM) type 1
(T1DM) and type 2 (T2DM) along with DM-induced complications. Most of them are included
in the well-known metabolic syndrome (MS). These metabolic dysfunctions in turn are
tightly associated to a high risk of development of cardiovascular diseases. Although molecular
mechanisms underlying the onset of metabolic dysfunctions and related complications are
not yet clear, it is widely recognized that they are associated to oxidative stress and chronic
low-grade of inflammatory levels.

Methods:
We undertook a structured search of bibliographic references through the use of
SciFinder. The database was provided by a division of ACS (American Chemical Society)
and guarantees access to the world's most extensive and authoritative source of references.
The search was performed using “heme oxygenase-1” as research topic and a subsequent refinement
was done by using inclusion/exclusion criteria. The quality of retrieved papers was
evaluated on the basis of standard tools.

Results:
From a careful review of the selected literature, of interest, the use of natural antioxidant
polyphenols seems to be the ideal pharmacological treatment since they are endowed
with strong antioxidant and anti-inflammatory properties. In particular, some polyphenols
such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently
activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression
of enzymes such as heme oxygenase-1 (HO-1). Indeed, an overexpression of HO-1 has been
demonstrated to play a beneficial role in metabolic diseases.

Conclusion:
The following review is intended to stimulate interest in the role of natural occurring
HO-1 inducers in metabolic dysfunction, focusing on the clinical potential of HO-1
activity to restore the balance between pro-oxidant and anti-oxidants systems.
Molecular Characterization of Fusarium Solani Degrades a Mixture of Low and High Molecular Weight Polycyclic Aromatic Hydrocarbons
Authors: Hesham Abd El-Latif , Mohamed Elsayed A. , Mawad Asmaa M.M. , Elfarash Ameer , Abd El-Fattah Bahaa S. , El-Rawy Mahmoud A. 
Published: June 2017

Objectives:This study evaluates the ability of a non-white rot fungus strain, HESHAM-1, to degrade a mixture of low (naphthalene and phenanthrene) and high (chrysene and benzo(a)pyrene) molecular weight polycyclic aromatic hydrocarbons (LMW and HMW PAHs).Methods:Strain HESHAM-1 was isolated from oil polluted soil by enrichment method using phenanthrene as the sole source of carbon and energy. The strain showed the ability to tolerate and degrade a mixture of both low and high molecular weight PAHs. In the presences of LMW-PAHs (naphthalene and phenanthrene) as co-substrate, chrysene and benzo(a)pyrene (HMW-PAHs) were, respectively degraded by the fungus strain HESHAM-1 which was confirmed by GC-MS analyses.Results:The degradation rate was found as 84.82% for naphthalene, 40.09% for phenanthrene, 57.84% for chrysene and 71.06% for benzo(a)pyrene at the end of 10 days. This is the first report describing the biodegradation of a mixture of four PAH compounds by non-white rot fungus strain HESHAM-1 isolated from Egyptian oil-polluted soil. The fungus strain HESHAM-1 was identified by morphological characteristics and molecular genetics technique based on PCR amplification and sequencing of the internal transcribed spacers (ITSs) of the rDNA region and intervening 5.8S rRNA gene. Blast result and phylogenetic analysis of gene sequencing suggested that strain HESHAM-1 was closely related toFusarium solaniwith 100% sequence identity.Conclusion:The present study clearly demonstrates that, strain HESHAM-1 could be used to remove the crude oil from the environment.
An Interrupted Time Series Analysis to Determine the Effect of an Electronic Health Record–Based Intervention on Appropriate Screening for Type 2 Diabetes in Urban Primary Care Clinics in New York City
Authors: Albu Jeanine B. , Sohler Nancy , Li Rui , Li Xuan , Young Edwin , Gregg Edward W. , Ross-Degnan Dennis 
Published: June 2017

OBJECTIVE
To determine the impact of a health system–wide primary care diabetes management system, which included targeted guidelines for type 2 diabetes (T2DM) and prediabetes (dysglycemia) screening, on detection of previously undiagnosed dysglycemia cases.

RESEARCH DESIGN AND METHODS
Intervention included electronic health record (EHR)–based decision support and standardized providers and staff training for using the American Diabetes Association guidelines for dysglycemia screening. Using EHR data, we identified 40,456 adults without T2DM or recent screening with a face-to-face visit (March 2011–December 2013) in five urban clinics. Interrupted time series analyses examined the impact of the intervention on trends in three outcomes: 1) monthly proportion of eligible patients receiving dysglycemia testing, 2) two negative comparison conditions (dysglycemia testing among ineligible patients and cholesterol screening), and 3) yield of undiagnosed dysglycemia among those tested.

RESULTS
Baseline monthly proportion of eligible patients receiving testing was 7.4–10.4%. After the intervention, screening doubled (mean increase + 11.0% [95% CI 9.0, 13.0], proportion range 18.6–25.3%). The proportion of ineligible patients tested also increased (+5.0% [95% CI 3.0, 8.0]) with no concurrent change in cholesterol testing (+0% [95% CI −0.02, 0.05]). About 59% of test results in eligible patients showed dysglycemia both before and after the intervention.

CONCLUSIONS
Implementation of a policy for systematic dysglycemia screening including formal training and EHR templates in urban academic primary care clinics resulted in a doubling of appropriate testing and the number of patients who could be targeted for treatment to prevent or delay T2DM.
Machado de Assis e as traduções que publicou em <i>Crisálidas</i>
Authors: Miranda José Américo 
Published: June 2017

Quando Machado de Assis publicou suas Poesias completas, em 1901, ele excluiu diversos poemas de seus três primeiros livros – Crisálidas (1864), Falenas (1870) e Americanas (1875). Todas essas obras continham poesias, de procedências diversas, traduzidas por Machado de Assis. Ao longo de sua trajetória, ele traduziu poetas de língua francesa, inglesa, alemã, italiana, polonesa, chinesa, além de um salmo bíblico. As seis poesias traduzidas que apareceram em Crisálidas foram todas excluídas por ele, ao passo que as dos outros dois livros passaram às Poesias completas. Este artigo examina as seis traduções presentes na primeira edição de Crisálidas e busca explicações para a exclusão delas, pelo próprio autor, de suas Poesias completas. ---DOI: http://dx.doi.org/10.25094/rtp.2017n22a359
O rasurado convite amoroso de Glauco Mattoso
Authors: Sodré Paulo Roberto , Quevedo Rafael Campos 
Published: June 2017

Discute o topos horaciano do convite amoroso e da profecia ameaçadora expresso em poemas de língua portuguesa, em especial de Glauco Mattoso, uma vez que este, poeta contemporâneo conhecido por seu sonetário herdado de Luís de Camões, Gregório de Matos e de Manuel Barbosa Maria du Bocage, declara-se herdeiro da tradição lírica de língua portuguesa. Os estudos de tópica literária de Francisco Achcar e de Antonio Candido, além de reflexões sobre o tema da imitação poética, como as de D. A. Russel e Raul Miguel Rosado Fernandes, serão os aportes teóricos para esta discussão. ---DOI: http://dx.doi.org/10.25094/rtp.2017n22a377
Representações das subjetividades femininas em <i>Babel bárbara</i>, de Cristina Peri Rossi
Authors: Marcari Maria de Fatima Alves Oliveira 
Published: June 2017

Em seu poemário Babel bárbara (1991), a escritora uruguaia Cristina Peri Rossi empreende uma busca pela mulher arquetípica e original, anterior à cultura patriarcal. Para tanto, a autora propõe a construção de uma linguagem simbólica feminina oposta à lógica falogocêntrica. Em nosso trabalho, pretendemos analisar como a autora reconstitui uma subjetividade primordial, centrada no feminino, contrapondo-se às teorizações de Lacan, que nega ao feminino qualquer protagonismo ontológico. Para tanto, contaremos com o apoio dos estudos críticos de Luce Irigaray (1985) e Cixous (1985,1992,1994), bem como das teorizações de Severo Sarduy (1978) sobre o neobarroco. ---DOI: http://dx.doi.org/10.25094/rtp.2017n22a387
Glauco Mattoso e a coprofagia de poéticas
Authors: Palmeiro Cecilia 
Published: June 2017

Este trabalho estuda os começos de escrita do Glauco Mattoso e a construção da sua figura de autor no contexto da abertura democrática no Brasil, na linha da poesia marginal e do desbunde. O ensaio analisa a relação entre literatura e política na origem das políticas do desejo no Brasil. ---DOI: http://dx.doi.org/10.25094/rtp.2017n22a442
Deep brain stimulation for the early treatment of the minimally conscious state and vegetative state: experience in 14 patients
Authors: Chudy Darko , Deletis Vedran , Almahariq Fadi , Marčinković Petar , Škrlin Jasenka , Paradžik Veronika 
Published: June 2017

OBJECTIVEAn effective treatment of patients in a minimally conscious state (MCS) or vegetative state (VS) caused by hypoxic encephalopathy or traumatic brain injury (TBI) is not yet available. Deep brain stimulation (DBS) of the thalamic reticular nuclei has been attempted as a therapeutic procedure mainly in patients with TBI. The purpose of this study was to investigate the therapeutic use of DBS for patients in VS or MCS.METHODSFourteen of 49 patients in VS or MCS qualified for inclusion in this study and underwent DBS. Of these 14 patients, 4 were in MCS and 10 were in VS. The etiology of VS or MCS was TBI in 4 cases and hypoxic encephalopathy due to cardiac arrest in 10. The selection criteria for DBS, evaluating the status of the cerebral cortex and thalamocortical reticular formation, included: neurological evaluation, electrophysiological evaluation, and the results of positron emission tomography (PET) and MRI examinations. The target for DBS was the centromedian-parafascicular (CM-pf) complex. The duration of follow-up ranged from 38 to 60 months.RESULTSTwo MCS patients regained consciousness and regained their ability to walk, speak fluently, and live independently. One MCS patient reached the level of consciousness, but was still in a wheelchair at the time the article was written. One VS patient (who had suffered a cerebral ischemic lesion) improved to the level of consciousness and currently responds to simple commands. Three VS patients died of respiratory infection, sepsis, or cerebrovascular insult (1 of each). The other 7 patients remained without substantial improvement of consciousness.CONCLUSIONSSpontaneous recovery from MCS/VS to the level of consciousness with no or minimal need for assistance in everyday life is very rare. Therefore, if a patient in VS or MCS fulfills the selection criteria (presence of somatosensory evoked potentials from upper extremities, motor and brainstem auditory evoked potentials, with cerebral glucose metabolism affected not more than the level of hypometabolism, which is judged using PET), DBS could be a treatment option.
A multimodal concept for invasive diagnostics and surgery based on neuronavigated voxel-based morphometric MRI postprocessing data in previously nonlesional epilepsy
Authors: Delev Daniel , Quesada Carlos M. , Grote Alexander , Boström Jan P. , Elger Christian , Vatter Hartmut , Surges Rainer 
Published: June 2017

OBJECTIVEDiagnosis and surgical treatment of refractory and apparent nonlesional focal epilepsy is challenging. Morphometric MRI voxel-based and other postprocessing methods can help to localize the epileptogenic zone and thereby support the planning of further invasive electroencephalography (EEG) diagnostics, and maybe resective epilepsy surgery.METHODSThe authors developed an algorithm to implement regions of interest (ROI), based on postprocessed MRI data, into a neuronavigation tool. This was followed by stereotactic ROI-guided implantation of depth electrodes and ROI-navigated resective surgery. Data on diagnostic yield, histology, and seizure outcome were collected and evaluated.RESULTSFourteen consecutive patients with apparently nonlesional epilepsy were included in this study. Reevaluation of the MR images with the help of MRI postprocessing analysis led to the identification of probable subtle lesions in 11 patients. Additional information obtained by SPECT imaging and MRI reevaluation suggested possible lesions in the remaining 3 patients. The ROI-guided invasive implantation of EEG yielded interictal and ictal activity in 13 patients who were consequently referred to resective surgery. Despite the apparently negative MRI findings, focal cortical dysplasia was found in 64% of the patients (n = 9). At the last available outcome, 8 patients (57%) were completely seizure free (International League Against Epilepsy Class 1).CONCLUSIONSThe results demonstrate the feasibility and usefulness of a robust and straightforward algorithm for implementation of MRI postprocessing-based targets into the neuronavigation system. This approach allowed the stereotactic implantation of a low number of depth electrodes only, which confirmed the seizure-onset hypothesis in 90% of the cases without causing any complications. Furthermore, the neuronavigated ROI-guided lesionectomy helped to perform resective surgery in this rather challenging subgroup of patients with apparent nonlesional epilepsy.
Endoscopic endonasal odontoid resection with real-time intraoperative image-guided computed tomography: report of 4 cases
Authors: Singh Harminder , Rote Sarang , Jada Ajit , Bander Evan D. , Almodovar-Mercado Gustavo J. , Essayed Walid I. , Härtl Roger , Anand Vijay K. , Schwartz Theodore H. , Greenfield Jeffrey P. 
Published: June 2017

The authors present 4 cases in which they used intraoperative CT (iCT) scanning to provide real-time image guidance during endonasal odontoid resection. While intraoperative CT has previously been used as a confirmatory test after resection, to the authors’ knowledge this is the first time it has been used to provide real-time image guidance during endonasal odontoid resection. The operating room setup, as well as the advantages and pitfalls of this approach, are discussed. A mobile intraoperative CT scanner was used in conjunction with real-time craniospinal neuronavigation in 4 patients who underwent endoscopic endonasal odontoidectomy for basilar invagination. All patients underwent a successful decompression. In 3 of the 4 patients, real-time intraoperative CT image guidance was instrumental in achieving a comprehensive decompression. In 3 (75%) cases in which the right nostril was the predominant working channel, there was a tendency for asymmetrical decompression toward the right side, meaning that residual bone was seen on the left, which was subsequently removed prior to completion of the surgery.Endoscopic endonasal odontoid resection with real-time intraoperative image-guided CT scanning is feasible and provides accurate intraoperative localization of pathology, thereby increasing the chance of a complete odontoidectomy. For right-handed surgeons operating predominantly through the right nostril, special attention should be paid to the contralateral side of the resection, where there is often a tendency for residual pathology.
Supreme Pastor of the Church Cares for the Hungarian Church: Church Architecture of the Hungarian Church During the First Decade of John Paul II’s Papacy
Authors: Garai Gréta , Vukoszávlyev Zorán 
Published: June 2017

One of the first longer letters of Pope John Paul II was addressed to the Hungarian Episcopacy and the Hungarian Catholics. Besides the traditional Polish-Hungarian friendship, he highlighted the person of Saint Stephen and the role of Hungary in the history of the Christian religion. “ […] the Catholic Church, which had such a significant role in the history of Hungary, can still pervade the spiritual image of your country, and can make the lightness of Jesus Christ’s gospel, that gave light to the sons of the Hungarian people during so many centuries, shine for your sons and daughters.”- wrote in his letter.
Evaluation of the Warping Model for Analysis of Polystyrene Concrete Slabs with Profiled Steel Sheeting
Authors: Cherednikov Volodymyr , Voskobiinyk Olena , Cherednikova Olexandra 
Published: June 2017

In this article the possibility of applying the warping model offered by V. G. Piskunov, A. V. Goryk and V. N. Cherednikov for analyzing polystyrene concrete slabs with profiled steel sheeting is considered. The adequacy of the offered model was verified by comparing the experimental and calculated deflections of the slab. Test specimens of polystyrene concrete slabs with profiled steel sheeting (PCSPSS) were made for experimental studies and then mechanical properties of the slab components – the polystyrene concrete and the profiled steel sheeting – were determined. Then the behaviour of slabs under a load was studied. The calculation of the warping model of PCSPSS was done at the same time. The obtained results have proved the possibility of applying of the offered warping model for analysis of PCSPSS. It is proposed to use the considered model for further study of the stress-strained state of inhomogeneous slabs.
Characterizing 51 Eri b from 1 to 5 μm: A Partly Cloudy Exoplanet
Authors: Rajan Abhijith , Rameau Julien , Rosa Robert J. De , Marley Mark S. , Graham James R. , Macintosh Bruce , Marois Christian , Morley Caroline , Patience Jennifer , Pueyo Laurent , Saumon Didier , Ward-Duong Kimberly , Ammons S. Mark , Arriaga Pauline , Bailey Vanessa P. , Barman Travis , Bulger Joanna , Burrows Adam S. , Chilcote Jeffrey , Cotten Tara , Czekala Ian , Doyon Rene , Duchêne Gaspard , Esposito Thomas M. , Fitzgerald Michael P. , Follette Katherine B. , Fortney Jonathan J. , Goodsell Stephen J. , Greenbaum Alexandra Z. , Hibon Pascale , Hung Li-Wei , Ingraham Patrick , Johnson-Groh Mara , Kalas Paul , Konopacky Quinn , Lafrenière David , Larkin James E. , Maire Jérôme , Marchis Franck , Metchev Stanimir , Millar-Blanchaer Maxwell A. , Morzinski Katie M. , Nielsen Eric L. , Oppenheimer Rebecca , Palmer David , Patel Rahul I. , Perrin Marshall , Poyneer Lisa , Rantakyrö Fredrik T. , Ruffio Jean-Baptiste , Savransky Dmitry , Schneider Adam C. , Sivaramakrishnan Anand , Song Inseok , Soummer Rémi , Thomas Sandrine , Vasisht Gautam , Wallace J. Kent , Wang Jason J. , Wiktorowicz Sloane , Wolff Schuyler 
Published: June 2017

Abstract
We present spectrophotometry spanning 1–5 μm of 51 Eridani b, a 2–10

planet discovered by the Gemini Planet Imager Exoplanet Survey. In this study, we present new K1 (1.90–2.19 μm) and K2 (2.10–2.40 μm) spectra taken with the Gemini Planet Imager as well as an updated L

P
(3.76 μm) and new M

S
(4.67 μm) photometry from the NIRC2 Narrow camera. The new data were combined with J (1.13–1.35 μm) and H (1.50–1.80 μm) spectra from the discovery epoch with the goal of better characterizing the planet properties. The 51 Eri b photometry is redder than field brown dwarfs as well as known young T-dwarfs with similar spectral type (between T4 and T8), and we propose that 51 Eri b might be in the process of undergoing the transition from L-type to T-type. We used two complementary atmosphere model grids including either deep iron/silicate clouds or sulfide/salt clouds in the photosphere, spanning a range of cloud properties, including fully cloudy, cloud-free, and patchy/intermediate-opacity clouds. The model fits suggest that 51 Eri b has an effective temperature ranging between 605 and 737 K, a solar metallicity, and a surface gravity of log(g) = 3.5–4.0 dex, and the atmosphere requires a patchy cloud atmosphere to model the spectral energy distribution (SED). From the model atmospheres, we infer a luminosity for the planet of −5.83 to −5.93 (

), leaving 51 Eri b in the unique position of being one of the only directly imaged planets consistent with having formed via a cold-start scenario. Comparisons of the planet SED against warm-start models indicate that the planet luminosity is best reproduced by a planet formed via core accretion with a core mass between 15 and 127

.
The Type Ia Supernova Color–Magnitude Relation and Host Galaxy Dust: A Simple Hierarchical Bayesian Model
Authors: Mandel Kaisey S. , Scolnic Daniel M. , Shariff Hikmatali , Foley Ryan J. , Kirshner Robert P. 
Published: June 2017

Abstract
Conventional Type Ia supernova (SN Ia) cosmology analyses currently use a simplistic linear regression of magnitude versus color and light curve shape, which does not model intrinsic SN Ia variations and host galaxy dust as physically distinct effects, resulting in low color–magnitude slopes. We construct a probabilistic generative model for the dusty distribution of extinguished absolute magnitudes and apparent colors as the convolution of an intrinsic SN Ia color–magnitude distribution and a host galaxy dust reddening–extinction distribution. If the intrinsic color–magnitude (M

B
versus B − V) slope

differs from the host galaxy dust law R

B
, this convolution results in a specific curve of mean extinguished absolute magnitude versus apparent color. The derivative of this curve smoothly transitions from

in the blue tail to R

B
in the red tail of the apparent color distribution. The conventional linear fit approximates this effective curve near the average apparent color, resulting in an apparent slope

between

and R

B
. We incorporate these effects into a hierarchical Bayesian statistical model for SN Ia light curve measurements, and analyze a data set of SALT2 optical light curve fits of 248 nearby SNe Ia at

. The conventional linear fit gives

. Our model finds

and a distinct dust law of

, consistent with the average for Milky Way dust, while correcting a systematic distance bias of ∼0.10 mag in the tails of the apparent color distribution. Finally, we extend our model to examine the SN Ia luminosity–host mass dependence in terms of intrinsic and dust components.
Yonsei Evolutionary Population Synthesis (YEPS). II. Spectro-photometric Evolution of Helium-enhanced Stellar Populations
Authors: Chung Chul , Yoon Suk-Jin , Lee Young-Wook 
Published: June 2017

Abstract
The discovery of multiple stellar populations in Milky Way globular clusters (GCs) has stimulated various follow-up studies on helium-enhanced stellar populations. Here we present the evolutionary population synthesis models for the spectro-photometric evolution of simple stellar populations (SSPs) with varying initial helium abundance (Y
ini). We show that Y
ini brings about dramatic changes in spectro-photometric properties of SSPs. Like the normal-helium SSPs, the integrated spectro-photometric evolution of helium-enhanced SSPs is also dependent on metallicity and age for a given Y
ini. We discuss the implications and prospects for the helium-enhanced populations in relation to the second-generation populations found in the Milky Way GCs. All of the models are available at http://web.yonsei.ac.kr/cosmic/data/YEPS.htm.