bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging treatments for classical myeloproliferative neoplasms
Authors: Vannucchi Alessandro M. , Harrison Claire N. 
Published: December 2016

AbstractThere has been a major revolution in the management of patients with myeloproliferative neoplasms (MPN), and in particular those with myelofibrosis and extensive splenomegaly and symptomatic burden, after the introduction of the JAK1 and JAK2 inhibitor ruxolitinib. The drug also has been approved as second-line therapy for polycythemia vera (PV). However, the therapeutic armamentarium for MPN is still largely inadequate for coping with patients’ major unmet needs, which include normalization of life span (myelofibrosis and some patients with PV), reduction of cardiovascular complications (mainly PV and essential thrombocythemia), prevention of hematological progression, and improved quality of life (all MPN). In fact, none of the available drugs has shown clear evidence of disease-modifying activity, even if some patients treated with interferon and ruxolitinib showed reduction of mutated allele burden, and ruxolitinib might extend survival of patients with higher-risk myelofibrosis. Raised awareness of the molecular abnormalities and cellular pathways involved in the pathogenesis of MPN is facilitating the development of clinical trials with novel target drugs, either alone or in combination with ruxolitinib. Although for most of these molecules a convincing preclinical rationale was provided, the results of early phase 1 and 2 clinical trials have been quite disappointing to date, and toxicities sometimes have been limiting. In this review, we critically illustrate the current landscape of novel therapies that are under evaluation for patients with MPN on the basis of current guidelines, patient risk stratification criteria, and previous experience, looking ahead to the chance of a cure for these disorders.
Evaluation of the effectiveness of an online transition planning program for adolescents on the autism spectrum: trial protocol
Authors: Hatfield Megan , Falkmer Marita , Falkmer Torbjorn , Ciccarelli Marina 
Published: December 2016

Abstract
Background
The transition from high school to post-secondary education and work is difficult for adolescents on the autism spectrum. Transition planning can be an effective way of supporting adolescents on the autism spectrum to prepare for leaving school and to succeed in obtaining employment; however, there is a need for an autism-specific transition planning program with proven effectiveness. This paper describes a trial protocol for evaluating the Better OutcOmes & Successful Transitions for Autism (BOOST-A™); an online interactive program that empowers adolescents on the autism spectrum to plan their transition from school to further study, training, or employment.

Methods
The trial will involve adolescents on the autism spectrum in high school and their parents, who will be alternately assigned to a control group (regular practice) or an intervention group (using the BOOST-A™). The BOOST-A™ was developed using the PRECEDE-PROCEED model, and is based on the self-determination model, and the strengths- and technology-based approaches. It involves participants completing a series of online modules. The primary outcome will be self-determination, because high self-determination has been linked to successful transition to employment among adolescents on the autism spectrum. Secondary outcomes will include domain-specific self-determination, career planning and exploration, quality of life, and environmental support. Data will be obtained from questionnaires completed by the adolescent on the autism spectrum and their parent/s. Data collection will take place at baseline (Time point 1) and 12 months later (Time point 2).

Discussion and conclusions
This trial will provide evidence of the effectiveness of the BOOST-A™ to assist adolescents on the autism spectrum to successfully transition from school.
Trial registration #ACTRN12615000119594
The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes
Authors: Knoch Tobias A. , Wachsmuth Malte , Kepper Nick , Lesnussa Michael , Abuseiris Anis , Ali Imam A. M. , Kolovos Petros , Zuin Jessica , Kockx Christel E. M. , Brouwer Rutger W. W. , van de Werken Harmen J. G. , van IJcken Wilfred F. J. , Wendt Kerstin S. , Grosveld Frank G. 
Published: December 2016

AbstractBackgroundThe dynamic three-dimensional chromatin architecture of genomes and its co-evolutionary connection to its function—the storage, expression, and replication of genetic information—is still one of the central issues in biology. Here, we describe the much debated 3D architecture of the human and mouse genomes from the nucleosomal to the megabase pair level by a novel approach combining selective high-throughput high-resolution chromosomal interaction capture (T2C), polymer simulations, and scaling analysis of the 3D architecture and the DNA sequence.ResultsThe genome is compacted into a chromatin quasi-fibre with ~5 ± 1 nucleosomes/11 nm, folded into stable ~30–100 kbp loops forming stable loop aggregates/rosettes connected by similar sized linkers. Minor but significant variations in the architecture are seen between cell types and functional states. The architecture and the DNA sequence show very similar fine-structured multi-scaling behaviour confirming their co-evolution and the above.ConclusionsThis architecture, its dynamics, and accessibility, balance stability and flexibility ensuring genome integrity and variation enabling gene expression/regulation by self-organization of (in)active units already in proximity. Our results agree with the heuristics of the field and allow “architectural sequencing” at a genome mechanics level to understand the inseparable systems genomic properties.
Impact on CDC Guideline Compliance after Incorporating Pharmacy in a Pneumococcal Vaccination Screening Process
Authors: Pickren Elizabeth , Crane Brad 
Published: December 2016

Background Centers for Disease Control and Prevention (CDC) guidelines for pneumococcal vaccinations were updated in 2014. Given the complexity of the guidelines and the fact that hospitals are no longer required to keep records for pneumococcal vaccinations, many hospitals are determining whether to continue this service. Objective The primary objective of this study was to determine the impact on compliance with the revised pneumococcal vaccination guidelines from the CDC after involving pharmacy in the screening and selection processes. Secondary objectives were to determine the impact of the new process on inappropriate vaccination duplications, the time spent by pharmacy on assessments, and financial outcomes. Methods This institutional review board (IRB)–approved, retrospective, cohort study examined all patients who received a pneumococcal vaccination from January to February 2016 after implementing a new process whereby pharmacy performed pneumococcal vaccination screening and selection (intervention group). These patients were compared to patients who received a pneumococcal vaccination from January to February 2015 (control group). Results Of 274 patients who received a pneumococcal vaccine, 273 were included in the study. Compliance to CDC guidelines increased from 42% to 97%. Noncompliant duplications decreased from 16% to 2%. In the intervention group, labor cost for assessments and expenditure for vaccines increased. For Medicare patients, the increased reimbursement balanced the increased expenditure in the intervention group. Conclusions Involving pharmacy in the pneumococcal vaccine screening and selection process improves compliance to CDC guidelines, but further clinical and financial analysis is needed to determine financial sustainability of the new process.
Impact of Targeted Educational Interventions on Clostridium difficile Infection Treatment in Critically Ill Adults
Authors: Hammond Drayton A. , Hughes Catherine A. , Painter Jacob T. , Pennick Rose E. , Chatterjee Kshitij , Boye Bradley , Meena Nikhil 
Published: December 2016

Background Clostridium diffcile infection (CDI) is a growing clinical and economic burden throughout the world. Pharmacists often are members of the primary care team in the intensive care unit (ICU) setting; however, the impact of pharmacists educating other health care providers on appropriateness of CDI treatment has not been previously examined. Objective This study was performed to determine the impact of structured educational interventions on CDI treatment on appropriateness of CDI treatment and clinical outcomes. Methods This was a single-center, retrospective, cohort study of patients with CDI in the medical ICU at an academic medical center between January and June 2014 (pre-period) and 2015 (post-period). All patients were evaluated for appropriate CDI treatment before and after implementing pharmacist-provided educational interventions on CDI treatment. Results Patients in the post-period were prescribed appropriate CDI treatment more frequently than patients in the pre-period (91.7% vs 41.7%; p = .03) and received fewer inappropriate doses of a CDI treatment agent (14 doses vs 30 doses). Patients in the pre-period had a shorter ICU length of stay [1.5 days (range, 1–19) vs 3.5 days (range, 2–36); p = .01] and a similar hospital length of stay [9.5 days (range, 4–24) vs 11.5 days (range, 3–56); p = .30]. Total time spent providing interventions was 4 hours. Conclusion Patients had appropriate CDI treatment initiated more frequently in the post-period. This low-cost intervention strategy should be easy to implement in institutions where pharmacists interact with physicians during clinical rounds and should be evaluated in institutions where interactions between pharmacists and physicians occur more frequently in non-rounding situations.
Stability of Levodopa/Carbidopa Rectal Suspensions
Authors: Donnelly Ronald F. 
Published: December 2016

Objective The combination of levodopa and carbidopa (L/C) is used as an effective therapy for treating Parkinson's disease; however when oropharyngeal dysphagia develops or when insertion of an nasogastric tube is not possible, then rectal administration could be used. To reduce compounding workload and establish a beyond use date, this study was conducted to determine the stability of 2 L/C rectal suspension formulations when stored at either 22°C or 5°C. Methods Two formulations of L/C rectal suspension were compounded and then packaged in amber polypropylene bottles. Three bottles of each formulation were stored at either 22°C or 5°C and analyzed at 11 time periods. Physical parameters such as caking, ease of resuspending, and pH were also determined at each time period. A validated stability-indicating high-performance liquid chromatography (HPLC) method was used to analyze both active ingredients. Results All solutions were easy to resuspend, there were no signs of caking, and there was no significant change in pH over the 35 days of storage at either temperature. The glycerin-based formulation (formulation 1) was less stable at 22°C (10 days) than formulation 2 (24 days). Both rectal suspensions were stable for 35 days when stored at 5°C. Conclusions The physical compatibility and chemical stability of 2 formulations of L/C rectal suspension packaged in amber polypropylene bottles was determined to be either 10 or 24 days when stored at 22°C or 35 days at 5°C.
Enhancing the luminance of converted green LEDs in LED projectors
Authors: Schulz Benjamin , Neumann Cornelius 
Published: December 2016

Abstract
High-power light-emitting diodes have successfully found their way into projection applications. Owing to their long lifetime, small size, and easy electrical drive, they are getting more and more attractive for use in various kinds of projectors. The challenge to achieve higher brightness levels lies in the étendue limitation, which is determined mainly by the size of the microdisplay inside the projection system. In this paper, a new approach is presented to increase the output flux of LED-based projectors by enhancing the luminance of converted green LEDs.
A taxonomic review of hymenolepidids (Eucestoda, Hymenolepididae) from dormice (Rodentia, Gliridae), with descriptions of two new species
Authors: Makarikov Arseny A. 
Published: December 2016

AbstractIn present study the systematic and taxonomic position of hymenolepidids parasitizing rodents of the family Gliridae from Europe and Central Asia is discussed.
Occurrence of Naegleria species in therapeutic geothermal water sources, Northern Iran
Authors: Latifi Ali Reza , Niyyati Maryam , Lorenzo-Morales Jacob , Haghighi Ali , Tabaei Seyyed Javad Seyyed , Lasjerdi Zohreh , Azargashb Eznolah 
Published: December 2016

AbstractPotentially pathogenic Free-Living Amoebae include members belonging to
Occurrence of two novel actinospore types (Cnidaria: Myxosporea) in Brazilian fish farms, and the creation of a novel actinospore collective group, Seisactinomyxon
Authors: Milanin Tiago , Atkinson Stephen D. , Silva Márcia R.M. , Alves Roberto G. , Maia Antônio A.M. , Adriano Edson A. 
Published: December 2016

AbstractThe involvement of oligochaetes in the life cycles of fresh water myxozoan parasites in Brazil was investigated. Of 333 oligochaetes collected in a fish farm in the State of São Paulo, three (0.9%) released Aurantiactinomyxon type spores. From 86 worms collected in a fish farm in Mato Grosso do Sul State, 1 (0.9%) released actinospores with a novel morphology for which we propose the name Seisactinomyxon. Infected oligochaetes were identified by morphology: all belonged to family Naididae, with
Dictyocaulosis in dairy cows in Brazil: an epidemiological, clinical-pathological and therapeutic approach
Authors: Henker Luan C. , Schwertz Claiton I. , Lucca Neuber J. , Piva Manoela M. , Giacomin Patricia , Gris Anderson , Rhoden Leandro A. , Norbury Luke J. , da Silva Aleksandro S. , da Rosa Rafael A. , Mendes Ricardo E. 
Published: December 2016

AbstractAn outbreak of severe parasitic pneumonia caused by
Transcriptional immune response in mesenteric lymph nodes in pigs with different levels of resistance to Ascaris suum
Authors: Skallerup Per , Nejsum Peter , Cirera Susanna , Skovgaard Kerstin , Pipper Christian B. , Fredholm Merete , Jørgensen Claus B. , Thamsborg Stig M. 
Published: December 2016

AbstractA single nucleotide polymorphism on chromosome 4 (SNP TXNIP) has been reported to be associated with roundworm
The first successful report of the in vitro life cycle of Chinese Leishmania: the in vitro conversion of Leishmania amastigotes has been raised to 94% by testing 216 culture medium compound
Authors: Li Jiao , Zheng Zhi-Wan , Natarajan Gayathri , Chen Qi-Wei , Chen Da-Li , Chen Jian-Ping 
Published: December 2016

AbstractChinese
Exploring possibilities for an alternative approach in experimental schistosomiasis mansoni: the peritoneal cavity of mice
Authors: Mati Vitor L.T. , Bicalho Rosilene S. , Melo Alan L. 
Published: December 2016

AbstractThe schistosome oviposition and granuloma constitution in the peritoneal cavity of AKR/J mice were evaluated. Groups of mice intraperitoneally infected with cercariae of
Morphological and molecular characterization of Cucullanus bourdini Petter et Le Bel, 1992 (Ascaridida: Cucullanidae) from the yellowback fusilier Caesio xanthonota Bleeker (Perciformes: Caesionidae)
Authors: Xu Zhen , Chen Hui-Xia , Ju Hui-Dong , Li Liang 
Published: December 2016

AbstractThe detailed morphology of
Report of fatal mixed infection with Cryptosporidium parvum and Giardia intestinalis in neonatal calves
Authors: Matsuura Yuu , Matsubayashi Makoto , Nukata Satoko , Shibahara Tomoyuki , Ayukawa Osamu , Kondo Yasuko , Matsuo Tomohide , Uni Shigehiko , Furuya Masaru , Tani Hiroyuki , Tsuji Naotoshi , Sasai Kazumi 
Published: December 2016

AbstractIn the production and management of beef and dairy cattle, controlling diarrhea is one of the important concerns. Pathogenic agents of the disease, protozoan parasites including
Lethal Angiostrongylus vasorum infection in a Hungarian dog
Authors: Benda Tibor , Csivincsik Ágnes , Nemes Csaba , Turbók Janka , Zsolnai Attila , Simonyai Erika , Majoros Gábor , Nagy Gábor 
Published: December 2016

AbstractDuring post-mortem examination of lungs and heart of a 7-month-old female French bulldog, 158 worms were collected from the lung vessels and they proved
Serosurvey of anti-Toxoplasma gondii antibodies in sport horses from Paraiba state, Northeastern Brazil
Authors: Almeida Jonatas C. , Vidotto Odilon , Ferreira Edlainne P. , Ribeiro Luana P.S. , Mongruel Anna C.B. , Vieira Thállitha S.W.J. , Freire Roberta L. , Mota Rinaldo A. , Vieira Rafael F.C. 
Published: December 2016

AbstractAlthough the infection by
Role and inhibition of Src signaling in the progression of liver cancer
Authors: Ren Hong , Fang Jie , Ding Xianjun , Chen Qiyun 
Published: December 2016

AbstractDuring 2012, about 782,500 new liver cancer cases were diagnosed and 745,500 deaths occurred all around the world. Liver cancer is the 2nd major cause of cancer death in men around the world and in underdeveloped countries. Dysregulation of the balance between proliferation and cell death, hepatitis B virus infection and hepatitis C virus chronic infection, and carcinogenic micro RNAs mainly contribute to the development and progression of liver cancer. Under physiological status, Src maintained the foundation of cells. While in liver cancer, it is known that the basic activities of cells are apparently disturbed possibly by Src. The mechanisms underlying the development and progression of liver cancer is needed to elucidate. In this study, we summarized newly found regulation pathway of SRC signaling, and clinical experience with inhibitors of Src signaling, such as, novel molecules that directly or indirectly targeted Src signaling which can be utilized in the treatment of liver cancer.
Effect of Trypsin on Antioxidant Activity and Gel-Rheology of Flaxseed Protein
Authors: Chang Yuan-yuan , Bi Chong-hao , Wang Li-jun , Li Dong , Adhikari Benu , Chen Xiao Dong 
Published: December 2016

Abstract
Enzymatic hydrolysis of flaxseed protein (FP) was carried out using trypsin in order to obtain flaxseed protein hydrolysates possessing better antioxidative property and modified rheological properties. The antioxidative properties of hydrolysates were much higher than the unhydrolyzed flaxseed protein. The hydrolysis also significantly reduced the hydrodynamic diameter of the magnitude of zeta potential of the dispersions. The gelling point of the hydrolysates occurred earlier than the unhydrolyzed sample while the duration of hydrolysis (30–120 min) did not affect gelling point of the hydrolysates. Considerable decrease in the gel strength and the frequency dependence of gel strength were observed in gels produced using hydrolyzed flaxseed protein. The above findings indicate that hydrolysates possessing high degree of antioxidative properties. The gels produces from these hydrolysates will have fast gelling property and will produce gels with reasonable strength. Thus, flaxseed protein hydrolysates obtained from trypsin hydrolysis can be used in applications that require proteins with higher antioxidative properties but softer texture.
A Novel Global ABC Algorithm with Self-Perturbing
Authors: Zhou Shuliang , Feng Dongqing , Ding Panpan 
Published: December 2016

Abstract
Artificial bee colony (ABC) is a kind of a metaheuristic population-based algorithms proposed in 2005. Due to its simple parameters and flexibility, the ABC algorithm is applied to engineering problems, algebra problems, and so on. However, its premature convergence and slow convergence speed are inherent shortcomings. Aiming at the shortcomings, a novel global ABC algorithm with self-perturbing (IGABC) is proposed in this paper. On the basis of the original search equation, IGABC adopts a novel self-adaptive search equation, introducing the guidance of the global optimal solution. The search method improves the convergence precision and the global search capacity. An excellent leader can lead the whole team to obtain more success. In order to obtain a better “leader,” IGABC proposes a novel method with global self-perturbing. To avoid falling into the local optimum, this paper designed a new mutation strategy that simulates the natural phenomenon of sick fish being eaten.
A Multiple Criteria-Based Cost Function Using Wavelet and Edge Transformation for Medical Image Steganography
Authors: Nipanikar S.I. , Hima Deepthi V. 
Published: December 2016

Abstract
With the ever-increasing need for concealing messages within cover media like image, video, and audio, numerous attempts have been developed for steganography. Most of the steganographic techniques perform their embedding operation on the cover image without selecting a better location. The right selection of location for embedding the information can lead to high imperceptibility and robustness. Accordingly, in this paper, we develop a new cost function for estimating the cost of every pixel to identify the good location to embed the message data. The proposed cost estimation procedure utilizes multiple parameters like wavelet coefficient, edge transformation, and pixel intensity. The proposed cost matrix is then utilized to embed the message data into the cover media using an embedding integer. The proposed steganographic technique is experimented with two magnetic resonance brain images, and the results are analyzed with the peak-to-peak signal-to-noise ratio (PSNR) and mean square error. The robustness analysis ensured that the proposed steganographic technique outperforms the existing methods by reaching the maximum PSNR of 72.74 dB.
Nanoscale hierarchical optical interactions for secure information
Authors: Tate Naoya , Naruse Makoto 
Published: December 2016

AbstractThere is increasing demand for novel physical security that can differentiate between real and false specific artifact that have been added to bank bills, certifications, and other vouchers. The most simple and effective method for improving the security level is to scale down the elemental structures so that they cannot be duplicated by attackers. While there is a paradox that the achieved fabrication resolution by a defender can also be realized by an attacker, further improvement in security is possible by the functional fusion of artifact metrics and nanophotonics. The fundamental advantages of this concept are the high-level clone resistance and individuality of nanoscale artifacts, which are based on the super-resolution fabrication and nanoscale hierarchical structure of optical near-field interactions, respectively. In this paper, the basis for the fabrication of nanoscale artifacts by utilizing random phenomena is described, and a quantitative evaluation of the security level is presented. An experimental demonstration using a nano-/macro-hierarchical hologram is presented to demonstrate the fundamental procedure for retrieving nanoscale features as hidden information. Finally, the concept and a simple demonstration of non-scanning probe microscopy are described as a practical application of the retrieval and authentication of nanoscale artifact metrics.