bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voltammetric Method for the Simultaneous Determination of Melatonin and Pyridoxine in Dietary Supplements Using a Cathodically Pretreated Boron‐doped Diamond Electrode
Authors: Alpar Nurcan , Pınar Pınar Talay , Yardım Yavuz , Şentürk Zühre 
Published: April 2017

AbstractThe simultaneous voltammetric determination of melatonin (MT) and pyridoxine (PY) has been carried out at a cathodically pretreated boron‐doped diamond electrode. By using cyclic voltammetry, a separation of the oxidation peak potentials of both compounds present in mixture was about 0.47 V in Britton‐Robinson buffer, pH 2. The results obtained by square‐wave voltammetry allowed a method to be developed for determination of MT and PY simultaneously in the ranges 1–100 μg mL−1 (4.3×10−6–4.3×10−4 mol L−1) and 10–175 μg mL−1 (4.9×10−5–8.5×10−4 mol L−1), with detection limits of 0.14 μg mL−1 (6.0×10−7 mol L−1) and 1.35 μg mL−1 (6.6×10−6 mol L−1), respectively. The proposed method was successfully to the dietary supplements samples containing these compounds for health‐caring purposes.
HnRNPM and CD44s expression affects tumor aggressiveness and predicts poor prognosis in breast cancer with axillary lymph node metastases
Authors: Sun Huizhi , Liu Tieju , Zhu Dongwang , Dong Xueyi , Liu Fang , Liang Xiaohui , Chen Chen , Shao Bing , Wang Meili , Wang Yi 
Published: April 2017

AbstractHnRNPM is an essential splicing factor and its expression is closely correlated with invasion and metastasis of tumor cells. The CD44 cell adhesion molecule is aberrantly expressed in many breast tumors and CD44 splice variants have been implicated in specific oncogenic signaling pathways. To investigate the clinical significance and biological function of hnRNPM, immunohistochemistry, quantitative, and semiquantitative polymerase chain reaction, lentiviral transfection system and transwell invasion assays were performed. We found that hnRNPM expression was significantly upregulated in breast cancer tissues compared with benign breast lesions. Although there was no significant correlation between hnRNPM and total CD44 protein or mRNA level, there was a negative correlation between hnRNPM and CD44v6. HnRNPM and CD44s expression showed positive correlation and in particular, they were dually expressed in breast cancer tissues. Interestingly, cancer stem cells marker, ALDH1+ phenotype was positively associated with overexpression of CD44s or hnRNPM and negatively related to CD44v6. Patients with high hnRNPM tended to have higher levels of CD44s, shorter overall survival (OS) and higher rates of lymph node metastases (LNM). Remarkably, Kaplan‐Meier and Cox regression analyses displayed that hnRNPM+ or CD44shigh was a poor prognostic factor for OS of patients with LNM. Upregulation of hnRNPM in MCF‐7 cells caused a significant increase in cell invasion, and this effect may occur through the regulation of CD44s expression. In conclusion, overexpression of hnRNPM promotes breast cancer aggressiveness by regulating the level of CD44s, indicates a poor prognosis for patients with LNM, and has potential as therapeutic targets.
The neuropsychology of delirium: advancing the science of delirium assessment
Authors: Tieges Zoë , Evans Jonathan J. , Neufeld Karin J. , MacLullich Alasdair M.J. 
Published: April 2017

ObjectiveThe diagnosis of delirium depends on eliciting its features through mental status examination and informant history. However, there is marked heterogeneity in how these features are assessed, from binary subjective clinical judgement to more comprehensive methods supported by cognitive testing. The aim of this article is to review the neuropsychological research in delirium and suggest future directions in research and clinical practice.MethodsWe reviewed the neuropsychological literature on formal assessment and quantification of the different domains in delirium, focusing on the core feature of inattention.ResultsFew studies have characterised and quantified the features of delirium using objective methods commonly employed in neuropsychological research. The existing evidence confirms that patients with delirium usually show impairments on objective tests of attention compared with cognitively intact controls and, in most cases, compared with patients with dementia. Further, abnormal level of arousal appears to be a specific indicator of delirium. The neuropsychological evidence base for impairments in other cognitive domains in delirium, including visual perception, language and thought processes, is small.ConclusionsDelirium diagnosis requires accurate testing for its features, but there is little neuropsychological research examining the nature of these features, or evaluating the reliability, validity and discriminatory power of existing assessment processes. More research using the neuropsychological approach has enormous potential to improve and standardise delirium assessment methods of the individual features of delirium, such as inattention, and in developing more robust reference standards to enable greater comparability between studies.
The impact of economic crisis on the Greek hospitals' productivity
Authors: Mitropoulos Panagiotis , Mitropoulos Ioannis , Karanikas Haralampos , Polyzos Nikolaos 
Published: April 2017

SummaryDuring the recent economic crisis, Greece implemented a comprehensive reform in the health care system. The 2010 health reform occurred under the constraints imposed by the memorandum of understanding that the Greek Government signed with its EU/International Monetary Fund creditors to control its deficit. The objective of the study is to examine the impact of the reform on the efficiency and productivity of public hospitals in Greece. We use the Malmquist productivity index to comparatively examine the potential changes before and after the reform years. We compare productivity, efficiency, and technological changes using panel data of 111 public acute hospitals operating in Greece throughout the recession period of 2009 to 2012. Bootstrapping methods are applied to allow for uncertainty owing to sampling error and for statistical inference for the Malmquist productivity index and its decompositions. The analysis indicates that the productivity has been increased following the policy changes. It appears that the expected benefits from the reform in general have been achieved, at least in the short‐term. This result is examined in the light of management and operations activities, which are related with the reform process. Therefore, at a second stage, the Malmquist index is regressed on variables that may potentially be statistically associated with productivity growth.
Multidomain truncated hemoglobins: New members of the globin family exhibiting tandem repeats of globin units and domain fusion
Authors: Hade Mangesh Dattu , Kaur Jagdeep , Chakraborti Pradip K. , Dikshit Kanak L. 
Published: April 2017

AbstractTruncated hemoglobins (trHbs) are considered the most primitive members of globin superfamily and traditionally exist as a single domain heme protein in three distinct structural organizations, type I (trHb1_N), type II (trHb2_O) and type III (trHb3_P). Our search of microbial and lower eukaryotic genomes revealed a broad array of multidomain organization, representing multiunit and chimeric forms of trHbs, where multiple units of trHbs are joined together and/or integrated with distinct functional domains. Globin motifs of these multidomain trHbs were from all three groups of trHbs and unambiguously assigned to trHb1_N, trHb2_O and trHb3_P. Multiunit and chimeric forms of trHb1_N were identified exclusively in ciliated protozoan parasites, where multiple units of trHb are integrated in tandem and/or fused with another redox active or signalling domain, presenting an interesting example of gene duplication and fusion in lower eukaryotes. In contrast, trHb2_O and trHb3_P trHbs were found only in bacteria in two or multidomain organization, where amino or carboxy terminus of trHb unit is integrated with different redox‐active or oxidoreductase domains. The identification of these new multiunit and chimeric trHbs and their specific phyletic distribution presents an interesting and challenging finding to explore and understand complex functionalities of these novel multidomain trHbs. © 2017 IUBMB Life, 69(7):479–488, 2017
Acculturative Stress, Parental and Professor Attachment, and College Adjustment in Asian International Students
Authors: Han Suejung , Pistole M. Carole , Caldwell Jarred M. 
Published: April 2017

This study examined parental and professor attachment as buffers against acculturative stress and as predictors of college adjustment of 210 Asian international students (AISs). Moderated hierarchical regression analyses revealed that acculturative stress negatively and secure parental and professor attachment positively predicted academic integration. Secure professor attachment positively predicted grade point average. Mother attachment may buffer against acculturative stress on academic integration; father attachment may exacerbate it. Counselors may use these findings to enhance AISs' attachment functioning for their college adjustment.Este estudio examinó el apego parental y el apego al profesor como protectores contra el estrés aculturativo y como indicadores de adaptación al entorno académico en 210 estudiantes internacionales asiáticos (AIS, por sus siglas en inglés). Los análisis de regresión jerárquica moderada revelaron que el estrés aculturativo fue un indicador negativo de integración académica, mientras que el apego parental y el apego al profesor fueron indicadores positivos. El apego seguro al profesor fue un indicador positivo de la media de las calificaciones académicas. El apego materno puede proteger contra el estrés aculturativo en la integración académica; el apego paterno puede agravarlo. Los consejeros pueden usar estos descubrimientos para enfatizar el funcionamiento del apego en los AIS para su adaptación al entorno académico.
Catalytic Activity of Cobalt Nanoparticles for Dye and 4‐Nitro Phenol Degradation: A Kinetic and Mechanistic Study
Authors: Khan Mohammad Naved , Bashir Ommer , Khan Tabrez Alam , Al‐Thabaiti Shaeel Ahmed , Khan Zaheer 
Published: April 2017

ABSTRACTCetyltrimethylammonium bromide (CTAB) capped nanosized α‐cobalt hydroxides (CoNPs) were prepared to the removal of Congo red at room temperature in the absence and presence of sunlight. UV/visible spectra reveal that the CoNPs and NaBH4 have no catalytic effects toward Congo red and 4‐nitrophenol (4‐NP) degradation, whereas CoNPs act as an efficient catalyst with a small amount of NaBH4. The catalytic reaction has an induction period followed by an autoacceleration, which depends on the [NaBH4]. The reaction follows fractional‐order kinetics with respect to [NaBH4] for Congo red degradation. The activation energies were found to be 24 and 74 kJ mol−1, respectively, for Congo red and 4‐NP catalyzed reactions. The AgNPs has no catalytic activity toward Congo red. The degradation pathway mechanism with observed kinetics has been proposed and discussed, which follows the following rate law:
Bone volume–to–total volume ratio measured in trabecular bone by single‐sided NMR devices
Authors: Brizi Leonardo , Barbieri Marco , Baruffaldi Fabio , Bortolotti Villiam , Fersini Chiara , Liu Huabing , Nogueira d'Eurydice Marcel , Obruchkov Sergei , Zong Fangrong , Galvosas Petrik , Fantazzini Paola 
Published: April 2017

PurposeReduced bone strength is associated with a loss of bone mass, usually evaluated by dual‐energy X‐ray absorptiometry, although it is known that the bone microstructure also affects the bone strength. Here, a method is proposed to measure (in laboratory) the bone volume–to–total volume ratio by single‐sided NMR scanners, which is related to the microstructure of the trabecular bone.MethodsThree single‐sided scanners were used on animal bone samples. These low‐field, mobile, low‐cost devices are able to detect the NMR signal, regardless of the sample sizes, without the use of ionizing radiations, with the further advantage of signal localization offered by their intrinsic magnetic field gradients.ResultsThe performance of the different single‐sided scanners have been discussed. The results have been compared with bone volume–to–total volume ratio by micro CT and MRI, obtaining consistent values.ConclusionsOur results demonstrate the feasibility of the method for laboratory analyses, which are useful for measurements like porosity on bone specimens. This can be considered as the first step to develop an NMR method based on the use of a mobile single‐sided device, for the diagnosis of osteoporosis, through the acquisition of the signal from the appendicular skeleton, allowing for low‐cost, wide screening campaigns. Magn Reson Med 79:501–510, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Dual‐Echo EPI sequence for integrated distortion correction in 3D time‐resolved hyperpolarized 13C MRI
Authors: Geraghty Benjamin J. , Lau Justin Y. C. , Chen Albert P. , Cunningham Charles H. 
Published: April 2017

PurposeTo provide built‐in off‐resonance correction in time‐resolved, volumetric hyperpolarized 13C metabolic imaging by implementing a novel dual‐echo 3D echo‐planar imaging (EPI) sequence and reconstruction.MethodsA spectral‐spatial pulse for single‐resonance excitation followed by a dual‐echo 3D EPI readout was implemented to provide 64 × 8 × 6 cm3 coverage at 5 × 5 × 5 mm3 nominal resolution. Multiple sources of EPI distortions were encoded using a multi‐echo 1H EPI reference scan. Phase maps computed from the reference scans were combined with a bulk 13C frequency offset encoded in the dual‐echo [1‐13C]pyruvate images to correct geometric distortion and improve spatial registration. The proposed scheme was validated in a phantom study, and in vivo [1‐13C]pyruvate and [1‐13C]lactate rat images were acquired with intentional transmit frequency deviations to assess the dual‐echo 3D EPI sequence.ResultsThe phantom study demonstrated improved spatial registration in off‐resonance corrected images. Close agreement was observed between metabolic kidney signal and the underlying anatomy in rat imaging experiments. Relative to a single‐echo acquisition, the coherent addition of the two corrected echoes provided the expected increase in signal‐to‐noise ratio by approximately
.ConclusionA novel dual‐echo 3D EPI acquisition sequence for integrated off‐resonance correction in hyperpolarized 13C imaging was developed and demonstrated. The proposed sequence offers clear advantages over flyback EPI for time‐resolved metabolic mapping. Magn Reson Med 79:643–653, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Protocol for follow up of hip arthroplasty in the long term: effect on revision (WHISTLER study)
Authors: Smith Lindsay K. , Lenguerrand Erik , Blom Ashley , Powell Jane , Palmer Shea 
Published: April 2017

AbstractTotal hip arthroplasty (THA) is highly successful for reducing pain and improving function, providing health‐related quality of life benefit. Demand for THA is increasing with associated increase in revision hip surgery. Hip arthroplasty surveillance (long‐term follow up) can identify asymptomatically failing THA to prepare for revision surgery, reducing potential for complications or complexity of surgery. However, it is unknown whether the surveillance of THA can be shown to improve the patient outcomes or reduce costs around revision surgery. With the current need to reduce unnecessary health consultations and to show the economic advantages of any service, the purpose of this study is to consider the relative effectiveness of hip arthroplasty surveillance on revision hip arthroplasty. This is a single‐centre, observational study in which consecutive patients undergoing aseptic revision of THA over 12 months in a large orthopaedic unit will be considered for participation. Primary outcome measures will be change in each of three valid patient‐reported scores from pre‐operatively to 12 months post‐surgery. Secondary outcomes will be the costs of treatment calculated using data obtained from the participants' hospital records and a self‐report questionnaire. An exploratory approach will be used to investigate the effect of surveillance on the outcomes of interest. A linear mixed method model will be used to study the change in scores between baseline and 12 months. The economic evaluation will be a cost–utility analysis, which compares the value of alternative interventions by attaching costs to the quality‐adjusted life years produced by each intervention.
Simultaneous Determination of Multiple Mechanical Parameters for a DNAN/HMX Melt‐Cast Explosive by Brazilian Disc Test Combined with Digital Image Correlation Method
Authors: Zhu Daoli , Zhou Lin , Zhang Xiangrong , Zhao Jiaye 
Published: April 2017

AbstractTensile strength, tensile modulus, compressive modulus, and Poisson's ratio are important mechanical parameters for brittle explosives. Generally, these parameters are separately measured by several different tests in which the homogeneity of specimens cannot be guaranteed, thus requiring a simultaneous determination of these mechanical parameters by one test. In this paper, simultaneous determination of multiple mechanical parameters of a DNAN/HMX melt‐cast explosive using Brazilian disc test combined with digital image correlation (DIC) method is described. The method would allow tensile strength, tensile modulus, compressive modulus, and Poisson′s ratio to be obtained simultaneously by one test, when the influences of rigid body motion have been effectively removed. The method principle was introduced in detail in this paper. The effect of temperature on the mechanical properties and the difference between the tensile modulus and compressive modulus of the DNAN/HMX melt‐cast explosive were investigated. The elastic constants and tensile strength were quantitatively analyzed and are qualitatively correct, which demonstrates the effectiveness of the presented method.
Performing Proximity
Authors: Hill Leslie , Paris Helen 
Published: April 2017

How does proximity between audiences and performers change the nature of live performance? How does it feel? How long can it last? How close is too close?
Exploring the rise of close encounter, immersive productions that shine a light on performer-audience relationships, this book considers the impact of space and proximity in live performance.
Drawing on their experience as internationally acclaimed performance artists, Leslie Hill and Helen Paris richly document their creative processes, performances and audience's responses in a series of illuminating case studies. Relating their practice to wider issues in contemporary performance and detailing workshop exercises that aid performance making, this unique fusion of artistic and academic reflection is crucial reading for students, scholars and practitioners alike.
Cereals, calories and change: exploring approaches to quantification in Indus archaeobotany
Authors: Bates J. , Petrie C.A. , Singh R.N. 
Published: April 2017

Abstract
Several major cereal groups have been identified as staples used by the pre-urban, urban and post-urban phase populations of the Indus Civilisation (3200–1500 BCE): wheat, barley, a range of small hulled millets and also rice, though their proportional exploitation is variable across space and over time. Traditional quantification methods examine the frequency, intensity and proportionality of the use of these crops and help ascertain the ‘relative importance’ of these cereals for Indus populations. However, this notion of ‘importance’ is abstracted from the daily lives of the people using these crops and may be biased by the differential production (as well as archaeological survival) of individual cereals. This paper outlines an alternative approach to quantifying Indus cereals by investigating proportions of calories. Cereals are predominantly composed of carbohydrates and therefore provided much of the daily caloric intake among many late Holocene farming populations. The four major cereal groups cultivated by Indus farmers, however, vary greatly in terms of calories per grain, and this has an impact on their proportional input to past diets. This paper demonstrates that, when converted to proportions of calories, the perceived ‘importance’ of cereals from five Indus sites changes dramatically, reducing the role of the previously dominant small hulled millet species and elevating the role of Triticoid grains. Although other factors will also have affected how a farmer perceived the role and importance of a crop, including its ecological tolerances, investments required to grow it, and the crop’s role in the economy, this papers suggests that some consideration of what cereals meant in terms of daily lives is needed alongside the more abstracted quantification methods that have traditionally been applied.
Bank Mergers in China: What Role for Competition?
Authors: HEALEY Deborah J. , CHENYING Zhang 
Published: April 2017

AbstractThis article examines the likely role of competition in the regulatory analysis of bank mergers in China. Despite financial reforms, the banking sector remains subject to a complex web of financial regulation, with industrial policy favouring stability to facilitate national economic development. While there are currently no Ministry of Commerce (MOFCOM) bank merger determinations under theAnti-Monopoly Law(AML), examples of MOFCOM’s merger analysis in other sensitive industries diverge from a pure competition-based analysis, favouring grounds linked to national economic development broadly within the terms of theAML. Given the importance of banking to the Chinese economy, this article argues that competition is unlikely to play a large part in any assessment of bank mergers by MOFCOM, particularly where a foreign bank is involved. Instead, issues linked to ‘national economic development’ and stability are likely to play the most important role, leading to less predictable merger approval outcomes.
10Be in the Akademii Nauk ice core – first results for CE 1590–1950 and implications for future chronology validation
Authors: VON ALBEDYLL LUISA , OPEL THOMAS , FRITZSCHE DIEDRICH , MERCHEL SILKE , LAEPPLE THOMAS , RUGEL GEORG 
Published: April 2017

ABSTRACTTemporal variations of the radionuclide 10Be are broadly synchronous across the globe and thus provide a powerful tool to synchronize ice core chronologies from different locations. We compared the 10Be record of the Akademii Nauk (AN) ice core (Russian Arctic) for the time period CE 1590–1950 to the 10Be records of two well-dated Greenland ice cores (Dye3 and NGRIP). A high correlation (r = 0.59) was found between the AN and Dye3 records whereas the correlation with NGRIP was distinctly lower (r = 0.45). Sources of deviations may include local fluctuations in the deposition of 10Be due to changes in the precipitation patterns, and artefacts due to the core-sampling strategy. In general, the existing age model was validated, confirming the AN ice core to be a unique and well-dated source of palaeoclimate parameters for the Russian Arctic. We further used numerical simulations to test the influence of the core-sampling strategy on the results and derived an optimized sampling strategy for the deeper parts of the ice core.