bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective effects of APOE e2 against disease progression in subcortical vascular mild cognitive impairment patients: A three-year longitudinal study
Authors: Kim Yeo Jin , Seo Sang Won , Park Seong Beom , Yang Jin Ju , Lee Jin San , Lee Juyoun , Jang Young Kyoung , Kim Sung Tae , Lee Kyung-Han , Lee Jong Min , Lee Jae-Hong , Kim Jae Seung , Na Duk L. , Kim Hee Jin 
Published: May 2017

AbstractAlthough the association between apolipoprotein E (APOE) genotype and disease progression is well characterized in patients with Alzheimer’s disease, such a relationship is unknown in patients with subcortical vascular cognitive impairment. We evaluated whether APOE genotype is associated with disease progression in subcortical vascular mild cognitive impairment (svMCI) patients. We prospectively recruited 72 svMCI patients (19 APOE4 carriers, 42 APOE3 homozygotes, and 11 APOE2 carriers). Patients were annually followed-up with brain MRI and neuropsychological tests for three years and underwent a second Pittsburgh compound B (PiB)-PET at a mean interval of 32.3 months. Amyloid-ß burden was quantified by PiB standardized uptake value ratio (SUVR), and the amount of small vessel disease was quantified by number of lacune and small vessel disease score on MRI. We also measured cortical thickness. During the three years of follow-up, compared to the APOE3 homozygotes, there was less increase in PiB SUVR among APOE2 carriers (p = 0.023), while the APOE genotype did not show significant effects on small vessel disease progression. APOE2 carriers also showed less cortical thinning (p = 0.023) and a slower rate of cognitive decline (p = 0.009) compared to those with APOE3 homozygotes. Our findings suggest that, in svMCI patients, APOE2 has protective effects against amyloid-ß accumulation, cortical thinning, and cognitive decline.
Disruption of SHH signaling cascade by SBE attenuates lung cancer progression and sensitizes DDP treatment
Authors: Du Jing , Chen Weiwei , Yang Lijuan , Dai Juanjuan , Guo Jiwei , Wu Yan , Gong Kaikai , Zhang Jian , Yu Ning , Xie Zhen , Xi Sichuan 
Published: May 2017

AbstractDeregulated Sonic Hedgehog (SHH) pathway facilitates the initiation, progression, and metastasis of Non-small cell lung cancer (NSCLC), confers drug resistance and renders a therapeutic interference option to lung cancer patients with poor prognosis. In this study, we screened and evaluated the specificity of a Chinese herb Scutellariabarbata D. Don extraction (SBE) in repressing SHH signaling pathway to block NSCLC progression. Our study confirmed that aberrant activation of the SHH signal pathway conferred more proliferative and invasive phenotypes to human lung cancer cells. This study revealed that SBE specifically repressed SHH signaling pathway to interfere the SHH-mediated NSCLC progression and metastasis via arresting cell cycle progression. We also found that SBE significantly sensitized lung cancer cells to chemotherapeutic agent DDP via repressing SHH components in vitro and in vivo. Mechanistic investigations indicated that SBE transcriptionally and specifically downregulated SMO and consequently attenuated the activities of GLI1 and its downstream targets in SHH signaling pathway, which interacted with cell cycle checkpoint enzymes to arrest cell cycle progression and lead to cellular growth inhibition and migration blockade. Collectively, our results suggest SBE as a novel drug candidate for NSCLC which specifically and sensitively targets SHH signaling pathway.
Thickness-dependent conductance in Sb2SeTe2 topological insulator nanosheets
Authors: Huang Shiu-Ming , Yan You-Jhih , Yu Shih-Hsun , Chou Mitch 
Published: May 2017

AbstractThe conductivity increases as thickness decreases in a series of Sb2SeTe2 topological insulator nanosheets with thickness ranging from 80 to 200 nm, where the sheet conductance is proportional to the thickness. The corresponding sheet conductance of the surface state is 8.7 e2/h which is consistent with the values extracted from the temperature dependent Shubnikov-de Haas oscillations at high magnetic fields. The extracted Fermi momentum is the same as the results from the ARPES value, and the Berry phase is π. These support that the thickness dependent sheet conductance originates from the combination of the surface state and the bulk state.
The Herpesvirus Nuclear Egress Complex Component, UL31, Can Be Recruited to Sites of DNA Damage Through Poly-ADP Ribose Binding
Authors: Sherry Maxwell R. , Hay Thomas J. M. , Gulak Michael A. , Nassiri Arash , Finnen Renée L. , Banfield Bruce W. 
Published: May 2017

AbstractThe herpes simplex virus (HSV) UL31 gene encodes a conserved member of the herpesvirus nuclear egress complex that not only functions in the egress of DNA containing capsids from the nucleus, but is also required for optimal replication of viral DNA and its packaging into capsids. Here we report that the UL31 protein from HSV-2 can be recruited to sites of DNA damage by sequences found in its N-terminus. The N-terminus of UL31 contains sequences resembling a poly (ADP-ribose) (PAR) binding motif suggesting that PAR interactions might mediate UL31 recruitment to damaged DNA. Whereas PAR polymerase inhibition prevented UL31 recruitment to damaged DNA, inhibition of signaling through the ataxia telangiectasia mutated DNA damage response pathway had no effect. These findings were further supported by experiments demonstrating direct and specific interaction between HSV-2 UL31 and PAR using purified components. This study reveals a previously unrecognized function for UL31 and may suggest that the recognition of PAR by UL31 is coupled to the nuclear egress of herpesvirus capsids, influences viral DNA replication and packaging, or possibly modulates the DNA damage response mounted by virally infected cells.
Impedance self-matching ultra-narrow linewidth fiber resonator by use of a tunable π-phase-shifted FBG
Authors: Jing Mingyong , Yu Bo , Hu Jianyong , Hou Huifang , Zhang Guofeng , Xiao Liantuan , Jia Suotang 
Published: May 2017

AbstractIn this paper, we present a novel ultra-narrow linewidth fiber resonator formed by a tunable polarization maintaining (PM) π-phase-shifted fiber Bragg grating and a PM uniform fiber Bragg grating with a certain length of PM single mode fiber patch cable between them. Theoretical prediction shows that this resonator has ultra-narrow linewidth resonant peaks and is easy to realize impedance matching. We experimentally obtain 3 MHz narrow linewidth impedance matched resonant peak in a 7.3 m ultra-long passive fiber cavity. The impedance self-matching characteristic of this resonator also makes itself particularly suitable for use in ultra-sensitive sensors, ultra-narrow band rejection optical filters and fiber lasers applications.
A One-Pot Three-Component Double-Click Method for Synthesis of [67Cu]-Labeled Biomolecular Radiotherapeutics
Authors: Fujiki Katsumasa , Yano Shinya , Ito Takeshi , Kumagai Yuki , Murakami Yoshinori , Kamigaito Osamu , Haba Hiromitsu , Tanaka Katsunori 
Published: May 2017

AbstractA one-pot three-component double-click process for preparing tumor-targeting agents for cancer radiotherapy is described here. By utilizing DOTA (or NOTA) containing tetrazines and the TCO-substituted aldehyde, the two click reactions, the tetrazine ligation (an inverse electron-demand Diels-Alder cycloaddition) and the RIKEN click (a rapid 6π-azaelectrocyclization), could simultaneously proceed under mild conditions to afford covalent attachment of the metal chelator DOTA or NOTA to biomolecules such as to albumin and anti-IGSF4 antibody without altering their activities. Subsequently, radiolabeling of DOTA- or NOTA-attached albumin and anti-IGSF4 antibody (an anti-tumor-targeting antibody) with [67Cu], a β−-emitting radionuclide, could be achieved in a highly efficient manner via a simple chelation with DOTA proving to be a more superior chelator than NOTA. Our work provides a new and operationally simple method for introducing the [67Cu] isotope even in large quantities to biomolecules, thereby representing an important process for preparations of clinically relevant tumor-targeting agents for radiotherapy.
Silver Nanoparticles-Decorated Titanium Oxynitride Nanotube Arrays for Enhanced Solar Fuel Generation
Authors: Soliman Khaled A. , Zedan Abdallah F. , Khalifa Ahmed , El-Sayed Hany A. , Aljaber Amina S. , AlQaradawi Siham Y. , Allam Nageh K. 
Published: May 2017

AbstractWe demonstrate, for the first time, the synthesis of highly ordered titanium oxynitride nanotube arrays sensitized with Ag nanoparticles (Ag/TiON) as an attractive class of materials for visible-light-driven water splitting. The nanostructure topology of TiO2, TiON and Ag/TiON was investigated using FESEM and TEM. The X-ray photoelectron spectroscopy (XPS) and the energy dispersive X-ray spectroscopy (EDS) analyses confirm the formation of the oxynitride structure. Upon their use to split water photoelectrochemically under AM 1.5 G illumination (100 mW/cm2, 0.1 M KOH), the titanium oxynitride nanotube array films showed significant increase in the photocurrent (6 mA/cm2) compared to the TiO2 nanotubes counterpart (0.15 mA/cm2). Moreover, decorating the TiON nanotubes with Ag nanoparticles (13 ± 2 nm in size) resulted in exceptionally high photocurrent reaching 14 mA/cm2 at 1.0 VSCE. This enhancement in the photocurrent is related to the synergistic effects of Ag decoration, nitrogen doping, and the unique structural properties of the fabricated nanotube arrays.
Effects of dietary methionine on breast muscle growth, myogenic gene expression and IGF-I signaling in fast- and slow-growing broilers
Authors: Wen Chao , Jiang Xueying , Ding Liren , Wang Tian , Zhou Yanmin 
Published: May 2017

AbstractThis study investigated the responses of fast- (FG) and slow- (SG) growing broilers to dietary methionine (Met) status. The broilers were subjected to low (LM, 0.38 and 0.28 g/100 g), adequate (AM, 0.51 and 0.42 g/100 g) and high (HM, 0.65 and 0.52 g/100 g) Met during 1–21 and 22–42 d, respectively. Compared with the LM diets, the AM and HM diets increased body weight gain only in the FG broilers. The HM diets increased breast muscle yield only in the FG broilers, although insulin-like growth factor-I (IGF-I) concentration was increased in both strains of broilers. The HM diets increased mRNA levels of myogenic regulatory factors (MRF4, Myf5) and myocyte enhancer factor 2 (MEF2A and MEF2B) in the FG broilers, and increased MEF2A and decreased myostatin mRNA level in the SG broilers. Extracellular signal-regulated kinase (ERK) phosphorylation of breast muscle was increased by the HM diets in both strains of broilers, but mechanistic target of rapamycin (mTOR) phosphorylation was increased by the AM and HM diets only in the FG broilers. These results reflect a strain difference in broiler growth and underlying mechanism in response to dietary Met.
Self-assembled levitating clusters of water droplets: pattern-formation and stability
Authors: Fedorets Alexander A. , Frenkel Mark , Shulzinger Evgeny , Dombrovsky Leonid A. , Bormashenko Edward , Nosonovsky Michael 
Published: May 2017

AbstractWater forms ordered hexagonally symmetric structures (snow crystals) in its solid state, however not as liquid. Typically, mists and clouds are composed of randomly moving small droplets lacking any ordered structure. Self-organized hexagonally patterned microdroplet clusters over locally heated water surfaces have been recently observed. However, many aspects of the phenomenon are far from being well understood including what determines droplets size, arrangement, and the distance between them. Here we show that the Voronoi entropy of the cluster tends to decrease indicating to their self-organization, while coupling of thermal effects and mechanical forces controls the stability of the clusters. We explain the balance of the long-range attraction and repulsion forces which stabilizes the cluster patterns and established the range of parameters, for which the clusters are stable. The cluster is a dissipative structure similar to self-organized Rayleigh–Bénard convective cells. Microdroplet formation plays a role in a variety effects from mist and clouds to aerosols. We anticipate that the discovery of the droplet cluster phenomenon and its explanation will provide new insights on the fundamental physical and chemical processes such as microdroplet role in reaction catalysis in nature as well as new tools for aerosol analysis and microfluidic applications.
Powder Metallurgy Processing of a WxTaTiVCr High-Entropy Alloy and Its Derivative Alloys for Fusion Material Applications
Authors: Waseem Owais Ahmed , Ryu Ho Jin 
Published: May 2017

AbstractThe WxTaTiVCr high-entropy alloy with 32at.% of tungsten (W) and its derivative alloys with 42 to 90at.% of W with in-situ TiC were prepared via the mixing of elemental W, Ta, Ti, V and Cr powders followed by spark plasma sintering for the development of reduced-activation alloys for fusion plasma-facing materials. Characterization of the sintered samples revealed a BCC lattice and a multi-phase structure. The selected-area diffraction patterns confirmed the formation of TiC in the high-entropy alloy and its derivative alloys. It revealed the development of C15 (cubic) Laves phases as well in alloys with 71 to 90at.% W. A mechanical examination of the samples revealed a more than twofold improvement in the hardness and strength due to solid-solution strengthening and dispersion strengthening. This study explored the potential of powder metallurgy processing for the fabrication of a high-entropy alloy and other derived compositions with enhanced hardness and strength.
Breeding histories and selection criteria for oilseed rape in Europe and China identified by genome wide pedigree dissection
Authors: Wang Xiaohua , Long Yan , Wang Nian , Zou Jun , Ding Guangda , Broadley Martin R. , White Philip J. , Yuan Pan , Zhang Qianwen , Luo Ziliang , Liu Peifa , Zhao Hua , Zhang Ying , Cai Hongmei , King Graham J. , Xu Fangsen , Meng Jinling , Shi Lei 
Published: May 2017

AbstractSelection breeding has played a key role in the improvement of seed yield and quality in oilseed rape (Brassica napus L.). We genotyped Tapidor (European), Ningyou7 (Chinese) and their progenitors with the Brassica 60 K Illumina Infinium SNP array and mapped a total of 29,347 SNP markers onto the reference genome of Darmor-bzh. Identity by descent (IBD) refers to a haplotype segment of a chromosome inherited from a shared common ancestor. IBDs identified on the C subgenome were larger than those on the A subgenome within both the Tapidor and Ningyou7 pedigrees. IBD number and length were greater in the Ningyou7 pedigree than in the Tapidor pedigree. Seventy nine QTLs for flowering time, seed quality and root morphology traits were identified in the IBDs of Tapidor and Ningyou7. Many more candidate genes had been selected within the Ningyou7 pedigree than within the Tapidor pedigree. These results highlight differences in the transfer of favorable gene clusters controlling key traits during selection breeding in Europe and China.
Identification and comparative analysis of the ovarian microRNAs of prolific and non-prolific goats during the follicular phase using high-throughput sequencing
Authors: Zi Xiang-dong , Lu Jian-yuan , Ma Li 
Published: May 2017

AbstractThe kidding rate is one of the most important economic traits for goat production, but the genetic mechanism that is associated with ovulation rate is poorly understood. Recently, increasing evidence has suggested that microRNAs (miRNAs) influence ovarian biological processes. The present study provides the first comparison of the ovarian miRNAs of prolific Jintang black goats (JTGs) and non-prolific Tibetan goats (TBGs) during the follicular phase using RNA-Seq technology. We generated 11.19 million (M) and 11.34 M clean reads from the TBG and JTG libraries, respectively, from which a total of 389 known miRNAs were identified and 142 novel miRNAs were predicted. A total of 191 miRNAs were differentially expressed between the two breeds. Among the 10 most abundant miRNAs, miR-21-5p was defined as differentially expressed miRNA with a higher level in the JTG library than in the TBG library, but the other miRNAs were not different between the breeds. The predicted miRNA-targeted genes were further analyzed by Gene Ontology and KEGG pathway analyses. The results revealed that miR-21, miR-99a, miRNA-143, let-7f, miR-493 and miR-200b may affect follicular development. These findings will increase the current understanding of the role of ovarian miRNAs in the regulation of ovulation rate in goats.
Seagrass morphometrics at species level in Moreton Bay, Australia from 2012 to 2013
Authors: Samper-Villarreal Jimena , Roelfsema Chris , Kovacs Eva M. , Adi Novi S. , Lyons Mitchell , Mumby Peter J. , Lovelock Catherine E. , Saunders Megan I. , Phinn Stuart R. 
Published: May 2017

AbstractSeagrass above, below and total biomass, density and leaf area, length and width were quantified at a species level for 122 sites over three sampling periods in Moreton Bay, Australia. Core samples were collected in two regions: (1) a high water quality region with varying species assemblages and canopy complexity (98 sites); and (2) along a turbidity gradient in the bay (24 sites within four locations). Core samples were collected using a 15 cm diameter×20 cm long corer. Seagrass dry biomass per component was quantified per species present in each sample. A total of 220 biomass and density data records are included, 130 from the high water quality region and 90 from the turbidity gradient. These data provide a detailed assessment of biomass, density and leaf metrics per species sampled from Moreton Bay over 2012–2013. In future, these can be used as a baseline to assess seasonal and spatial variation within the bay, within the region and among regions.
Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models
Authors: Dingledine Raymond , Coulter Douglas A. , Fritsch Brita , Gorter Jan A. , Lelutiu Nadia , McNamara James , Nadler J. Victor , Pitkänen Asla , Rogawski Michael A. , Skene Pate , Sloviter Robert S. , Wang Yu , Wadman Wytse J. , Wasterlain Claude , Roopra Avtar 
Published: May 2017

AbstractGlobal expression profiling of neurologic or psychiatric disorders has been confounded by variability among laboratories, animal models, tissues sampled, and experimental platforms, with the result being that few genes demonstrate consistent expression changes. We attempted to minimize these confounds by pooling dentate granule cell transcriptional profiles from 164 rats in seven laboratories, using three status epilepticus (SE) epilepsy models (pilocarpine, kainate, self-sustained SE), plus amygdala kindling. In each epilepsy model, RNA was harvested from laser-captured dentate granule cells from six rats at four time points early in the process of developing epilepsy, and data were collected from two independent laboratories in each rodent model except SSSE. Hierarchical clustering of differentially-expressed transcripts in the three SE models revealed complete separation between controls and SE rats isolated 1 day after SE. However, concordance of gene expression changes in the SE models was only 26–38% between laboratories, and 4.5% among models, validating the consortium approach. Transcripts with unusually highly variable control expression across laboratories provide a ‘red herring’ list for low-powered studies.
Serum glycopattern and Maackia amurensis lectin-II binding glycoproteins in autism spectrum disorder
Authors: Qin Yannan , Chen Yanni , Yang Juan , Wu Fei , Zhao Lingyu , Yang Fuquan , Xue Peng , Shi Zhuoyue , Song Tusheng , Huang Chen 
Published: May 2017

AbstractThe pathophysiology of autistic spectrum disorder (ASD) is not fully understood and there are no diagnostic or predictive biomarkers. Glycosylation modified as many as 70% of all human proteins can sensitively reflect various pathological changes. However, little is known about the alterations of glycosylation and glycoproteins in ASD. In this study, serum glycopattern and the maackia amurensis lectin-II binding glycoproteins (MBGs) in 65 children with ASD and 65 age-matched typically developing (TD) children were compared by using lectin microarrays and lectin-magnetic particle conjugate-assisted LC-MS/MS analyses. Expression of Siaα2-3 Gal/GalNAc was significantly increased in pooled (fold change = 3.33, p < 0.001) and individual (p = 0.009) serum samples from ASD versus TD children. A total of 194 and 217 MGBs were identified from TD and ASD sera respectively, of which 74 proteins were specially identified or up-regulated in ASD. Bioinformatic analysis revealed abnormal complement cascade and aberrant regulation of response-to-stimulus that might be novel makers or markers for ASD. Moreover, increase of APOD α2-3 sialoglycosylation could sensitively and specifically distinguish ASD samples from TD samples (AUC is 0.88). In conclusion, alteration of MBGs expression and their sialoglycosylation may serve as potential biomarkers for diagnosis of ASD, and provide useful information for investigations into the pathogenesis of ASD.
A Novel Sensitive Luminescence Probe Microspheres for Rapid and Efficient Detection of τ-Fluvalinate in Taihu Lake
Authors: Wang Jixiang , Wang Yunyun , Qiu Hao , Sun Lin , Dai Xiaohui , Pan Jianming , Yan Yongsheng 
Published: May 2017

AbstractFluorescent molecularly imprinted polymers have shown great promise in biological or chemical separations and detection, due to their high stability, selectivity and sensitivity. In this work, fluorescent molecularly imprinted microsphere was synthesized via precipitation polymerization, which could separate efficiently and rapidly detect τ-fluvalinate (a toxic insecticide) in water samples, was reported. The fluorescent imprinted sensor showed excellent stability, outstanding selectivity and the limit of detection low to 12.14 nM, good regeneration ability which still kept good sensitivity after 8 cycling experiments and fluorescence quenching mechanism was illustrated in details. In addition, the fluorescent sensor was further used to detect τ-fluvalinate in real samples from Taihu Lake. Despite the relatively complex components of the environment water, the fluorescent imprinted microspheres sitll showed good recovery, clearly demonstrating the potental value of this smart sensor nanomaterial in environment monitoring.