bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of an integrated pharmacy supply management strategy
Authors: Amerine Lindsey B. , Calvert Daniel R. , Pappas Ashley L. , Lee Sarah M. , Valgus John M. , Savage Scott W. 
Published: December 2017

Abstract

Purpose
Implementation of an integrated pharmacy supply management strategy is described.

Summary
In 2011, the formulary approval process and supply management for oncology medications were independent of each other at an oncology infusion center. Numerous nonformulary medications were kept on hand and reordered based on inventory levels that were established with inadequate usage information, while some formulary agents did not have on-hand inventory levels and had to be reordered on a patient-specific basis, which required paperwork and then a review by drug information staff per institutional policy. Because there was no true distinction in the ordering of formulary versus nonformulary oncology agents, the medical staff prescribed both in the same manner, leaving the pharmacy staff responsible for ensuring that enough quantities were on hand for many drugs, regardless of formulary status. Using supply chain management principles, a formal analysis of the on-hand inventory was performed. In addition, the formulary process for oncology drugs was restructured to align with how oncology drugs are managed for on-hand inventory levels. The alignment of these processes allowed the operation to have 1 supply strategy for the ambulatory oncology infusion center. As a result, inventory exhaustion rates were reduced by 70% and inventory turn rates improved by 78%. There was also significant time savings in the operational process streamlining, eliminating the rework and inefficiencies caused by an unclear process that was not fully captured in this assessment.

Conclusion
Alignment of the formulary review process with inventory analyses that support supply management principles reduced inventory exhaustion while improving inventory turn rates.
Aquifer parameter and zonation structure estimation using meshless local Petrov–Galerkin method and particle swarm optimization
Authors: Swathi Boddula , Eldho T. I. 
Published: December 2017

Abstract
The simulation-optimization (SO) modeling approach can be effectively used for aquifer parameter estimation. In this study, a numerical approach based on meshless local Petrov–Galerkin (MLPG) method is used for groundwater flow simulation and coupled with particle swarm optimization model for optimization. The study deals with the identification of the most suitable model structure for a hypothetical heterogeneous confined aquifer from a number of alternate models using zonation method of parameter estimation. A range of alternate models starting from homogeneous to more complex model structures are considered for the zonation. Inverse modeling of different model structures is carried out based on weighted least square performance criterion. The suitable models are selected and reliability analysis ascertained by computing three parameters of composite scaled sensitivity, coefficient of variation, and confidence interval, and the best model is selected. Sensitivity of estimated parameters is investigated by considering different sets of head data involving possible measurement errors. The solutions are compared with another inverse model using the MLPG and Levenberg–Marquardt algorithm. Based on the results, it is found that the proposed methodology can be utilized in the estimation of different unknown parameters in a regional groundwater system.
Removal of nitrate from water by acid-washed zero-valent iron/ferrous ion/hydrogen peroxide: influencing factors and reaction mechanism
Authors: Li Yongye , Fu Fenglian , Ding Zecong 
Published: December 2017

Abstract
In this paper, a system consisting of acid-washed zero-valent iron (ZVI), ferrous ion (Fe2+), and hydrogen peroxide (H2O2) was employed for the removal of nitrate (NO3−) from water, and the reaction mechanism for this is discussed. The effects of acid-washed ZVI, Fe2+, H2O2, and initial NO3− concentration on nitrate removal were investigated. Acid-washed ZVI before and after reaction with nitrate were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). Results reveal that the combined system can enhance the corrosion of ZVI and facilitate aqueous nitrate reduction. The products of nitrate reduction are mainly ammonium, with some N2. The ZVI particles after reaction may have a core of ZVI with an oxidation layer mainly consisting of Fe3O4.
Effect of Mortar Reduction in Recycled Aggregates Used in Concrete
Authors: Letelier Viviana , Tarela Ester , Muñoz Pedro 
Published: December 2017

Background:Following a global environmental concern, concrete manufactured with recycled materials has been widely studied. The reuse of concrete as raw material can reduce the amount of debris and the amount of natural resources needed minimizing the environmental impact.Objective:One of the fundamental issues when using recycled aggregates is the mortar that remains adhered to their surfaces. The effect of this adhered mortar on aggregates, obtained from pavement demolition debris, used in recycled concrete is studied.Method:A mechanical abrasion process is used to reduce the amount of mortar in different degrees from the recycled aggregates that will be used to replace a 40 % of natural coarse aggregates in structural concrete. The mechanical behavior is studied through the compressive and flexural strength of the material and compared with the values obtained for a control concrete, with no recycled aggregates.Results:The abrasion process is proven to be effective eliminating the adhered mortar to the aggregates and the results show that a medium abrasion level, around 200rev, improves significantly the mechanical properties of the recycled concrete, increasing its compressive strength.Conclusion:The percentage of recycled aggregates used in structural concrete can be increased if these are treated with simple mechanical abrasion. The residuals of the eliminated mortar can be also reused as cement replacement, maximizing the material reuse.
MODELLING AND CONTROL OF H-SHAPED RACING QUADCOPTER WITH TILTING PROPELLERS
Authors: Alkamachi Ahmed , Ercelebi Ergun 
Published: December 2017

Traditional quadcopter suffers terribly from its underactuation which implies the coupling between the rotational and the translational motion. In this paper, we present a quadcopter with dynamic rotor tilting capability in which the four propellers are allowed to tilt together around their arm axis. The proposed model provides leveled forward/backward horizontal motion and therefore, ensures a correct view of the onboard camera, and increases the vehicle speed by reducing the air drag. The rotor tilt mechanism also provides an instant high speed in the forward or reverse direction and offers a quick and solid air brake to restrain that fast moving speed. The nonlinear dynamical model for the quadcopter under consideration is derived using Newton-Euler formalization. A control strategy is then proposed aimed to control the altitude, attitude, and the forward speed of the obtained model. Finally, a numerical simulation is used to integrate the system model with the controller and to test the system performance. Simulation results are reported to demonstrate the advantages of the proposed novel configuration.
Architectural Imaginaries: From Nomadism to the Volunteer Prisoners of Architecture
Authors: Muniz Ribeiro Diego Mauro 
Published: December 2017

<p>The present study deals with changes in the architectural imaginary between the late 1950s and early 1970s, especially with regard to the promises of unrestricted mobility (architecture and technology in favor of a society that would know no frontiers) and the subsequent representations, in which architecture not only continues to perpetuate exclusion and regimes of segregation but also assigns a desirable status to this process.</p><p>------</p><p>El presente estudio trata sobre los cambios en el imaginario arquitectónico entre finales de la década de 1950 e inicios de la de 1970,<br />especialmente al respecto de las promesas de movilidad ilimitada (arquitectura y tecnología a favor de una sociedad que no conocería fronteras) y las representaciones subsecuentes en las que la arquitectura no sólo continúa perpetuando los regímenes de exclusión y segregación, sino que asigna a este proceso un estatus deseable.</p>
Contentious Narratives in Amazonian Cities Along the Brazil–Bolivia Border: Memories and Resentments Turned Heroic and Glorious
Authors: Bento da Silva Francisco , De Araujo Souza Jairo , Messina Marcello 
Published: December 2017

<p>The purpose of this article is the comparative study of monuments in<br />Cobija (Bolivia) and Rio Branco (Brazil), unearthing the contentious national narratives that each of these two Amazonian border cities sustains as a result of the historical dispute over control of the region that today composes the southern part of the Brazilian state of Acre. We explore the different ways in which monuments on both sides of the border draw on narratives of national pride that allude to this conflict.</p>
Unsteady behaviours of a volute in turbocharger turbine under pulsating conditions
Authors: Yang Mingyang , Martinez-Botas Ricardo F. , Rajoo Srithar , Ibaraki Seiichi , Yokoyama Takao , Deng Kangyao 
Published: December 2017

Abstract
Turbochargers are currently in their prime utilization period, which pushes for performance enhancement from conventional turbochargers and more often than not revisiting its design methodology. A turbocharger turbine is subjected to pulsating flow, and how this feeds a steady flow design volute is a topic of interest for performance enhancement. This article investigates unsteady effects on flow characteristics in the volute of a turbine under pulsating flow conditions by numerical method validated by experimental measurement. A single pulse with sinusoidal shape is imposed at the turbine inlet for the investigation on unsteady behaviours. First, pulse propagation of different flow parameters along the volute passage, including pressure, temperature and mass flow rate, is studied by the validated numerical method. Next, the unsteady effect of the pulsating flow on the flow angle upstream the rotor inlet is confirmed by simulation results. The mechanism of this unsteady effect is then studied by an analytical model, and two factors for flow angle distributions are clearly demonstrated: the configuration of the volute A/Rc and the unsteady effect that resulted from mass imbalance. This article demonstrates unsteady behaviours of the turbine volute under pulsating conditions, and the mechanism is discussed in details, which can lead to the improvement of volute design methodology tailoring for pulsating flow conditions.
DESIGN E SUSTENTABILIDADE: NECESSIDADE DE QUEBRA DE PARADIGMA NO ENSINO
Authors: Pazmino Ana Veronica , Santos Adriane Shibata dos 
Published: December 2017

O artigo defende a necessidade de que nos cursos de design o tema da sustentabilidade seja inserido nos períodos iniciais e permeie o curso nas disciplinas posteriores, sendo tratado como relevante e praticado nas ações projetuais. Assim, pode-se esperar que nos projetos realizados pelos alunos de design sejam considerados problemas sociais e ambientais, além de outras questões relacionadas à sustentabilidade. Apesar do MEC ter estabelecido Diretrizes Curriculares Nacionais para a Educação Ambiental, Relações Étnico Raciais e Direitos Humanos, no artigo é apresentada uma pesquisa sobre a oferta destas temáticas em disciplinas nos cursos de Santa Catarina. O artigo finalmente propõe um modelo interdisciplinar da sustentabilidade nos cursos de design, visando que os designers do futuro sejam conscientes e responsáveis da sua atividade
A SUSTENTABILIDADE NO ENSINO DE DESIGN EM INSTITUIÇÕES FEDERAIS DE ENSINO SUPERIOR NO BRASIL
Authors: Calegari Eliana Paula , De Oliveira Branca Freitas 
Published: December 2017

Este estudo tem como objetivo analisar a inserção dos aspectos relacionados à sustentabilidade nos cursos de design em Instituições Federais de Ensino Superior no Brasil. Dessa forma, apresenta-se a identificação das Instituições Federais de Ensino Superior que possuem cursos na área de design, realizada através da plataforma e-MEC no período de outubro de 2015. A partir disso, foi realizado o levantamento da estrutura curricular das disciplinas que abordam a sustentabilidade, através do site das universidades, e por meio das ementas foi realizada a análise de conteúdo visando diagnosticar como ocorre a abordagem da sustentabilidade nos cursos de design. A pesquisa revelou que nas ementas dos cursos de design, que abordam disciplinas sobre a sustentabilidade, o ensino é baseado na problemática ambiental, abordando questões como o respeito ao meio ambiente, a qualidade de vida, a consciência ambiental, a preservação dos recursos naturais e impactos ambientais, e, além disso, são apresentadas estratégias de ecodesign a fim de minimizar impactos ambientais provocados durante o ciclo de vida dos produtos.
FSW of bimodal reinforced Al-based composites produced via spark plasma sintering
Authors: Sadeghi Behzad , Shamanian Morteza , Ashrafizadeh Fakhreddin , Cavaliere Pasquale 
Published: December 2017

Abstract
Metal-matrix composites produced via spark plasma sintering are characterized by enhanced mechanical and microstructural properties. Obviously, the material behavior is strongly related to the reinforcement properties, in particular the reinforcement shape. The present paper is aimed at showing the friction stir welding of Al-based composites reinforced with different percentages of nano (2%) and microsized (8%) alumina particles. The joints, microstructural and mechanical properties were evaluated as a function of the different processing parameters such as rotating and advancing speeds of the tool. The joint evolution was related to the heat input during welding. The welded material fracture behavior showed different types of rupture compared to the spark plasma sintered material.
Direct visualization of microcirculation impairment after acute subdural hemorrhage in a novel animal model
Authors: Wang Huan-Chih , Tsai Jui-Chang , Lee Jing-Er , Huang Sheng-Jean , Po-Hao Huang Abel , Lin Wei-Chou , Hsieh Sung-Tsang , Wang Kuo-Chuan 
Published: December 2017

OBJECTIVEDirect brain compression and secondary injury due to increased intracranial pressure are believed to be the pathognomic causes of a grave outcome in acute subdural hemorrhage (aSDH). However, ischemic damage from aSDH has received limited attention. The authors hypothesized that cerebral microcirculation is altered after aSDH. Direct visualization of microcirculation was conducted in a novel rat model.METHODSA craniectomy was performed on each of the 18 experimental adult Wistar rats, followed by superfusion of autologous arterial blood onto the cortical surface. Changes in microcirculation were recorded by capillary videoscopy. Blood flow and the partial pressure of oxygen in the brain tissue (PbtO2) were measured at various depths from the cortex. The brain was then sectioned for pathological examination. The effects of aspirin pretreatment were also examined.RESULTSInstantaneous vasospasm of small cortical arteries after aSDH was observed; thrombosis also developed 120 minutes after aSDH. Reductions in blood flow and PbtO2 were found at depths of 2–4 mm. Blood-brain barrier disruption and thrombi formation were confirmed using immunohistochemical staining, while aspirin pretreatment reduced thrombosis and the impairment of microcirculation.CONCLUSIONSMicrocirculation impairment was demonstrated in this aSDH model. Aspirin pretreatment prevented the diffuse thrombosis of cortical and subcortical vessels after aSDH.
Negative surgical exploration in patients with Cushing’s disease: benefit of two-thirds gland resection on remission rate and a review of the literature
Authors: Carr Steven B. , Kleinschmidt-DeMasters Bette K. , Kerr Janice M. , Kiseljak-Vassiliades Katja , Wierman Margaret E. , Lillehei Kevin O. 
Published: December 2017

OBJECTIVEThe authors report their single-institution experience with the pathological findings, rates of remission, and complications in patients with presumed Cushing’s disease (CD) who underwent a two-thirds pituitary gland resection when no adenoma was identified at the time of transsphenoidal surgery (TSS). The authors also review the literature on patients with CD, negative surgical exploration, and histological findings.METHODSThis study is a retrospective analysis of cases found in neurosurgery and pathology department databases between 1989 and 2011. In all cases, patients had been operated on by the same neurosurgeon (K.O.L.). Twenty-two (13.6%) of 161 patients who underwent TSS for CD had no adenoma identified intraoperatively after systematic exploration of the entire gland; these patients all underwent a two-thirds pituitary gland resection. A chart review was performed to assess treatment data points as well as clinical and biochemical remission status.RESULTSOf the 22 patients who underwent two-thirds gland resection, 6 (27.3%) ultimately had lesions found on final pathology. All 6 patients were found to have a distinct adrenocorticotropic hormone (ACTH) cell adenoma. Sixteen (72.7%) of the patients had no tumor identified, with 3 of these patients suspected of having ACTH cell hyperplasia. The follow-up duration for the entire group was between 14 and 315 months (mean 98.9 months, median 77 months). Remission rates were 100% (6/6 patients) for the ACTH cell adenoma group and 75% (12/16) for the group without adenoma. Overall, 18 (81.8%) of the 22 patients had no evidence of hypercortisolism at last follow-up, and 4 patients (18%) had persistent hypercortisolism, defined as a postoperative cortisol level > 5 μg/dl. Of these 4 patients, 1 was suspected of harboring a cavernous sinus adenoma, 2 were found to have lung tumors secreting ACTH, and 1 remained with an undiagnosed etiology. Rates of postoperative complications were low.CONCLUSIONSThe diagnosis and treatment of CD can be challenging for neurosurgeons, endocrinologists, and pathologists alike. Failure to find a discrete adenoma at the time of surgery occurs in at least 10%–15% of cases, even in experienced centers. The current literature provides little guidance regarding rational intraoperative approaches in such cases. The authors’ experience with 161 patients with CD, when no intraoperative tumor was localized, demonstrates the utility of a two-thirds pituitary gland resection with a novel and effective surgical strategy, as suggested by a high initial remission rate and a low operative morbidity.
Mitochondrial abnormalities related to the dysfunction of circulating endothelial colony-forming cells in moyamoya disease
Authors: Choi Jung Won , Son Sung Min , Mook-Jung Inhee , Moon Youn Joo , Lee Ji Yeoun , Wang Kyu-Chang , Kang Hyun-Seung , Phi Ji Hoon , Choi Seung Ah , Chong Sangjoon , Byun Jayoung , Kim Seung-Ki 
Published: December 2017

OBJECTIVEMoyamoya disease (MMD) is a unique cerebrovascular disorder characterized by the progressive occlusion of the bilateral internal carotid arteries. Endothelial colony-forming cells (ECFCs), previously termed “endothelial progenitor cells,” play an important role in the pathogenesis of MMD. In this study, the authors performed morphological and functional studies of the mitochondria of ECFCs from patients with MMD to present new insights into the pathogenesis of the disease.METHODSThe morphology of ECFCs from 5 MMD patients and 5 healthy controls was examined under both a transmission electron microscope and a confocal laser scanning microscope. The oxygen consumption rates (OCRs), mitochondrial membrane potentials (MMPs), intracellular Ca2+ concentrations, mitochondrial enzyme activities, and reactive oxygen species (ROS) levels were measured. Functional activity of the ECFCs was evaluated using a capillary tube formation assay.RESULTSThe ECFCs from the MMD patients displayed a disrupted mitochondrial morphology, including a shorter and more circular shape. The ECFC mitochondria from the MMD patients exhibited functional abnormalities, which were assessed as a decreased OCR and an increased intracellular Ca2+ concentration. Moreover, the ECFCs from MMD patients showed increased ROS levels. Interestingly, treatment with an ROS scavenger not only reversed the mitochondrial abnormalities but also restored the angiogenic activity of the ECFCs from the MMD patients.CONCLUSIONSThe mitochondria of ECFCs from MMD patients, as compared with those from healthy patients, exhibited morphological and functional abnormalities. This finding suggests that the mitochondrial abnormalities may have a role in the pathogenesis of MMD.
Pragmatic Diction:Owen Barfield, the Inklings and Pragmatism
Authors: Maddalena Prof. Giovanni 
Published: December 2017

Owen Barfield (1898-1997) has been a very eclectic writer: poet, novelist, and philosopher. Though almost unknown to philosophy scholars, his thought has been very influential on the work of C.S. Lewis and J.R.R. Tolkien and it is worth being studied, understood, and used in connection with pragmatism. His philosophy amounts to a strong metaphysical realism that can parallel Peirce’s view of scholastic realism and, more generally, the pragmatist attitude toward a comprehension of reality based on continuity. Moreover, Barfield sustains a view of knowledge as ‘participation’ that is very close to Peirce’s understanding of knowledge as representation. Finally, he proposes a form of ‘synthetic’ reasoning that goes the same direction as many classical pragmatists’ attempts. Therefore, the threefold philosophical aim of this paper is (1) to introduce Owen Barfield’s main theories, (2) to show the parallel between Barfield’s and pragmatists’, and especially Peirce’s tenets, and (3) to show how pragmatism and Barfield’s theory can be reciprocally useful Men do not invent those mysterious relationsbetween separate external objects,and between objects and feelings or ideas,which it is the function of poetry to reveal.These relations exist independently, not indeed of Thoughtbut of any individual thinker. (Poetic Diction, 79)
Determining the Elemental and Isotopic Composition of the Pre-solar Nebula from Genesis Data Analysis: The Case of Oxygen
Authors: Laming J. Martin , Heber V. S. , Burnett D. S. , Guan Y. , Hervig R. , Huss G. R. , Jurewicz A. J. G. , Koeman-Shields E. C. , McKeegan K. D. , Nittler L. R. , Reisenfeld D. B. , Rieck K. D. , Wang J. , Wiens R. C. , Woolum D. S. 
Published: December 2017

Abstract
We compare element and isotopic fractionations measured in bulk solar wind samples collected by NASA’s Genesis mission with those predicted from models incorporating both the ponderomotive force in the chromosphere and conservation of the first adiabatic invariant in the low corona. Generally good agreement is found, suggesting that these factors are consistent with the process of solar wind fractionation. Based on bulk wind measurements, we also consider in more detail the isotopic and elemental abundances of O. We find mild support for an O abundance in the range 8.75–8.83, with a value as low as 8.69 disfavored. A stronger conclusion must await solar wind regime-specific measurements from the Genesis samples.