bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Incident Seizure in Systemic Lupus Erythematosus
Authors: Huang XiangYang , Magder Laurence S. , Petri Michelle 
Published: January 2016

Objective.The risk factors for incident seizures in systemic lupus erythematosus (SLE) were prospectively determined in a cohort study.Methods.A total of 2203 patients with SLE followed longitudinally in the Hopkins Lupus Cohort were analyzed. Demographic variables, clinical manifestations, laboratory tests, and SLE disease activity were recorded at each quarterly visit. Adjusted estimates of association of risk factors for onset of seizure were derived using pooled logistic regression. We examined incident seizures in 3 ways: at the time of diagnosis, more than 45 days after the diagnosis of SLE, and after cohort entry.Results.Of 2203 patients with no history of seizure prior to SLE diagnosis, 157 (7.13%) had the first seizure occurrence at the time of (37 patients, 1.68%) or after diagnosis (120 patients, 5.45%) of SLE. The risk of seizure occurring around the time of SLE diagnosis was higher in patients with a history of malar rash (p = 0.002), proteinuria (p = 0.004), and psychosis (p < 0.001). Multivariable analysis of the first seizure occurring after the diagnosis of SLE showed that history of low C3 (p = 0.0078), psychosis (p < 0.0001), cranial or peripheral neuropathy (p = 0.0043), anti-Sm antibody (p = 0.0551), renal involvement (p = 0.0177), and current corticosteroid dose (p < 0.0001) were independently associated with a higher incidence of seizure. Disease activity was not predictive after adjusting for corticosteroids.Conclusion.Risk of seizure after diagnosis of SLE is increased in those patients with prior psychosis, neuropathy, proteinuria, anti-Sm, low C3, and use of corticosteroids.
A Prospective Study Investigating Prediagnostic Leukocyte Telomere Length and Risk of Developing Rheumatoid Arthritis in Women
Authors: Prescott Jennifer , Karlson Elizabeth W. , Orr Esther H. , Zee Robert Y.L. , De Vivo Immaculata , Costenbader Karen H. 
Published: January 2016

Objective.To prospectively examine the association between leukocyte telomere length (LTL) and subsequent rheumatoid arthritis (RA) development in women.Methods.Using a case-control design nested within the prospective Nurses’ Health Study (NHS), NHS II (NHSII), and Women’s Health Study (WHS), each validated case of RA with a prediagnostic blood sample was matched to 3 controls by cohort, age, menopausal status, postmenopausal hormone therapy, and blood collection covariates. We measured telomere length in genomic DNA extracted from stored buffy coat samples using quantitative PCR. We used unconditional logistic regression to determine OR and 95% CI, and random-effects metaanalysis to combine study results.Results.In total, we analyzed 296 incident RA cases and 827 matched controls. Mean age of diagnosis among women who developed RA was 60.5 in NHS/NHSII and 61.3 in WHS. Metaanalysis demonstrated that longer prediagnostic LTL was associated with increased RA risk when women in the longest versus shortest LTL tertile were compared (OR 1.51, 95% CI 1.03–2.23, pheterogeneity = 0.27). However, statistically significant between-study heterogeneity was observed for the intermediate tertile category (pheterogeneity = 0.008). We did not observe heterogeneity by menopausal status, inflammatory cytokine levels, age at diagnosis, age at blood collection, body mass index, seropositivity, or HLA-DRβ1 shared epitope status.Conclusion.Our results do not support an involvement for short LTL preceding RA development.
Examining the Minimal Important Difference of Patient-reported Outcome Measures for Individuals with Knee Osteoarthritis: A Model Using the Knee Injury and Osteoarthritis Outcome Score
Authors: Mills Kathryn A.G. , Naylor Justine M. , Eyles Jillian P. , Roos Ewa M. , Hunter David J. 
Published: January 2016

Objective.To examine the influence of different analytical methods, baseline covariates, followup periods, and anchor questions when establishing a minimal important difference (MID) for individuals with knee osteoarthritis (OA). Second, to propose MID for improving and worsening on the Knee injury and Osteoarthritis Outcome Score (KOOS).Methods.Retrospective analysis of prospectively collected data from 272 patients with knee OA undergoing a multidisciplinary nonsurgical management strategy. The magnitude and rate of change as well as the influence of baseline covariates were examined for 5 KOOS subscales over 52 weeks. The MID for improving and worsening were investigated using 4 anchor-based methods.Results.Waitlisted for joint replacement and exhibiting unilateral/bilateral symptoms influenced change in KOOS over time. Generally, low correlations between anchors and KOOS change scores limited calculations of MID; thus, they were only proposed for the pain, activities of daily living, and quality of life subscales. The method used to calculate the MID influenced the cutpoint; however, the type of anchor question only influenced the MID when analyzed with a particular mean change method. Depending on patient and clinical characteristics, the subscale, and the analytical approach used, the MID for KOOS improvement ranged from an absolute change of −1.5 to 20.6 points and worsening ranged from −19.17 to 8.5 points.Conclusion.MID vary with patient and clinical characteristics, KOOS subscale, and analytical approach. Provided the anchor question is relevant to the patient-reported outcome and baseline status is considered, the anchor does not appear to influence the MID for improvement or worsening when using some anchor-based methods.
Incremental Costs for Psoriasis and Psoriatic Arthritis in a Population-based Cohort in Southern Sweden: Is It All Psoriasis-attributable Morbidity?
Authors: Löfvendahl Sofia , Petersson Ingemar F. , Theander Elke , Svensson Åke , Zhou Caddie , Steen Carlsson Katarina 
Published: January 2016

Objective.To estimate incremental costs for patients with psoriasis/psoriatic arthritis (PsO/PsA) compared to population-based referents free from PsO/PsA and estimate costs attributable specifically to PsO/PsA.Methods.Patients were identified by International Classification of Diseases, 10th ed., codes for PsO/PsA using information from 1998 to 2007 in the Skåne Healthcare Register, covering healthcare use for the population of the Skåne region of Sweden. For each patient, 3 population-based referents were selected. Data were retrieved from Swedish registers on healthcare, drugs, and productivity loss. The human capital method was used to value productivity losses. Mean annual costs for 2008 to 2011 were assessed from a societal perspective.Results.We identified 15,283 patients fulfilling the inclusion criteria for PsO [n = 12,562, 50% women, mean age (SD) 52 (21) yrs] or PsA [n = 2721, 56% women, mean age 54 (16) yrs] and included 45,849 referents. Mean annual cost per patient with PsO/PsA was 55% higher compared to referents: €10,500 vs €6700. The cost was 97% higher for PsA compared to PsO. Costs due to productivity losses represented the largest share of total costs, ranging from 52% for PsO to 60% for PsA. Biological drug costs represented 10% of the costs for PsA and 1.6% for PsO. The proportion of cost identified as attributable to PsO/PsA problems was greatest among the patients with PsA (drug costs 71% and healthcare costs 31%).Conclusion.Annual mean incremental societal cost per patient was highest for PsA, mainly because of productivity losses and biological treatment. A minor fraction of the costs were identified as attributable to PsO/PsA specifically, indicating an increased morbidity in these patients that needs to be further investigated.
Monocytic Angiotensin and Endothelin Receptor Imbalance Modulate Secretion of the Profibrotic Chemokine Ligand 18
Authors: Rademacher Judith , Kill Angela , Mattat Kathrin , Dragun Duska , Siegert Elise , Günther Jeannine , Riemekasten Gabriela 
Published: January 2016

Objective.To assess monocytic expression and ratio of angiotensin and endothelin receptors in systemic sclerosis (SSc) and their functional relevance.Methods.Receptor expression was measured by flow cytometry. Chemokine ligand 18 (CCL18) concentration in supernatants of peripheral blood mononuclear cells stimulated with immunoglobulin G was measured by ELISA.Results.Monocytes of patients with SSc presented an increased angiotensin II Type 1 receptor (AT1R)/AT2R ratio compared with those of healthy donors. Patients with lung fibrosis and patients with high modified Rodnan skin score showed a reduced endothelin 1 Type A receptor (ETAR)/ETBR ratio. High AT1R/AT2R, but low ETAR/ETBR ratios corresponded to higher CCL18 secretion.Conclusion.Altered angiotensin and endothelin receptor ratios observed in SSc influence autoantibody-mediated effects such as secretion of profibrotic CCL18.
Venous and Arterial Thrombotic Events in Systemic Lupus Erythematosus
Authors: Hinojosa-Azaola Andrea , Romero-Diaz Juanita , Vargas-Ruiz Angel Gabriel , Nuñez-Alvarez Carlos A. , Cicero-Casarrubias Alba , Ocampo-Torres Mario C. , Sanchez-Guerrero Jorge 
Published: January 2016

Objective.The incidence of thrombosis in patients with systemic lupus erythematosus (SLE) is 25 to 50-fold higher than in the general population; we aimed to define the characteristics of venous thrombotic events (VTE) and arterial thrombotic events (ATE) to identify the patients at highest risk.Methods.The study included 219 patients with recent-onset SLE. At baseline, standardized medical history and laboratory tests were done. Followup visits occurred quarterly, and information about damage accrual, comorbidities, and cardiovascular risk factors was updated annually. Main outcome was development of TE after SLE diagnosis.Results.Thirty-five patients (16%) developed TE (27 VTE, 8 ATE) during 5.21 years of followup; incidence rate 31/1000 patient-years. Most events (57%) developed within the first year of diagnosis, and 69% were not associated with lupus anticoagulant (LAC), determined with 1 method. VTE developed earlier than ATE (2.0 vs 57.5 mos, p = 0.02). In the multivariate analysis, variables preceding VTE included cutaneous vasculitis, nephrotic syndrome, dose of prednisone, and LAC in combination with anti-RNP/Sm antibodies (p < 0.03). Patients with ATE were older (median age 44 vs 29 yrs, p = 0.04), smokers, and had hypertension, diabetes mellitus, dyslipidemia, at least 2 traditional risk factors, nephrotic syndrome, chronic damage, and a higher cumulative dose of prednisone (p < 0.05). LAC in combination with anti-RNP/Sm antibodies was associated with VTE and improved the accuracy for predicting it.Conclusion.Our study suggests that in SLE, VTE and ATE have different risk factors. Understanding these differences is helpful for identifying patients at highest risk. The use of LAC plus anti-RNP/Sm for predicting VTE deserves further study.
The Framingham Score and the Systematic Coronary Risk Evaluation at Low Cutoff Values Are Useful Surrogate Markers of High-risk Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis
Authors: Dessein Patrick H. , Corrales Alfonso , Lopez-Mejias Raquel , Solomon Ahmed , Woodiwiss Angela J. , Llorca Javier , Norton Gavin R. , Genre Fernanda , Blanco Ricardo , Pina Trinitario , Gonzalez-Juanatey Carlos , Tsang Linda , Gonzalez-Gay Miguel A. 
Published: January 2016

Objective.We determined the performance of the Framingham score and the Systematic COronary Risk Evaluation (SCORE) in assessing high-risk atherosclerosis in patients with rheumatoid arthritis (RA).Methods.We assembled 330 cases without established cardiovascular disease (CVD), diabetes, and moderate or severe chronic kidney disease among 451 consecutive Spanish patients who underwent CVD risk screening and carotid ultrasound-determined plaque assessment. The findings were validated in 90 black and 97 white African patients.Results.When sensitivity for the Framingham score was set at 80% in receiver-operator curve analysis [area under the curve (AUC) = 0.799], the corresponding cutoff value and specificity were 7.3% and 63%, respectively. At a specificity of 80%, the cutoff value and sensitivity were 10.8% and 65%, respectively. When sensitivity for SCORE (AUC = 0.747) was set at 80%, the cutoff value and specificity were 0.5% and 58%, respectively. At a specificity of 80%, the cutoff value and sensitivity were 1.5% and 50%, respectively. Upon applying a cutoff value of 7.3% for the Framingham and 0.5% for SCORE in African white patients with RA, the corresponding sensitivities and specificities were 67% and 72%, and 67% and 55%, respectively. CVD risk equations did not discriminate between black African patients with and without plaque (AUC = 0.544 and 0.549 for Framingham score and SCORE, respectively).Conclusion.The Framingham score and SCORE at markedly low cutoff values of 7.3% to 10.8% and 0.5% to 1.5%, respectively, can usefully estimate plaque presence in RA. Effective population-specific CVD risk assessment strategies are needed in black African patients with RA.
Development of System-level Performance Measures for Evaluation of Models of Care for Inflammatory Arthritis in Canada
Authors: Barber Claire E.H. , Marshall Deborah A. , Mosher Dianne P. , Akhavan Pooneh , Tucker Lori , Houghton Kristin , Batthish Michelle , Levy Deborah M. , Schmeling Heinrike , Ellsworth Janet , Tibollo Heidi , Grant Sean , Khodyakov Dmitry , Lacaille Diane ,   The Arthritis Alliance of Canada Performance Measurement Development Panel
Published: January 2016

Objective.To develop system-level performance measures for evaluating the care of patients with inflammatory arthritis (IA), including rheumatoid arthritis (RA), psoriatic arthritis, ankylosing spondylitis, and juvenile idiopathic arthritis.Methods.This study involved several methodological phases. Over multiple rounds, various participants were asked to help define a set of candidate measurement themes. A systematic search was conducted of existing guidelines and measures. A set of 6 performance measures was defined and presented to 50 people, including patients with IA, rheumatologists, allied health professionals, and researchers using a 3-round, online, modified Delphi process. Participants rated the validity, feasibility, relevance, and likelihood of use of the measures. Measures with median ratings ≥ 7 for validity and relevance were included in the final set.Results.Six performance measures were developed evaluating the following aspects of care, with each measure being applied separately for each type of IA except where specified: waiting times for rheumatology consultation for patients with new onset IA, percentage of patients with IA seen by a rheumatologist, percentage of patients with IA seen in yearly followup by a rheumatologist, percentage of patients with RA treated with a disease-modifying antirheumatic drug (DMARD), time to DMARD therapy in RA, and number of rheumatologists per capita.Conclusion.The first set of system-level performance measures for IA care in Canada has been developed with broad input. The measures focus on timely access to care and initiation of appropriate treatment for patients with IA, and are likely to be of interest to other arthritis care systems internationally.
Improved Function and Reduced Pain after Swimming and Cycling Training in Patients with Osteoarthritis
Authors: Alkatan Mohammed , Baker Jeffrey R. , Machin Daniel R. , Park Wonil , Akkari Amanda S. , Pasha Evan P. , Tanaka Hirofumi 
Published: January 2016

Objective.Arthritis and its associated joint pain act as significant barriers for adults attempting to perform land-based physical activity. Swimming can be an ideal form of exercise for patients with arthritis. Yet there is no information on the efficacy of regular swimming exercise involving patients with arthritis. The effect of a swimming exercise intervention on joint pain, stiffness, and physical function was evaluated in patients with osteoarthritis (OA).Methods.Using a randomized study design, 48 sedentary middle-aged and older adults with OA underwent 3 months of either swimming or cycling exercise training. Supervised exercise training was performed for 45 min/day, 3 days/week at 60–70% heart rate reserve for 12 weeks. The Western Ontario and McMaster Universities Arthritis Index was used to measure joint pain, stiffness, and physical limitation.Results.After the exercise interventions, there were significant reductions in joint pain, stiffness, and physical limitation accompanied by increases in quality of life in both groups (all p < 0.05). Functional capacity as assessed by maximal handgrip strength, isokinetic knee extension and flexion power (15–30% increases), and the distance covered in the 6-min walk test increased (all p < 0.05) in both exercise groups. No differences were observed in the magnitude of improvements between swimming and cycling training.Conclusion.Regular swimming exercise reduced joint pain and stiffness associated with OA and improved muscle strength and functional capacity in middle-aged and older adults with OA. Additionally, the benefits of swimming exercise were similar to the more frequently prescribed land-based cycling training. Trial registration: clinicaltrials.govNCT01836380.
Éloquence de la chaire et éloquence du barreau : une rivalité dans la seconde moitié du xvii e siècle ?
Authors: Simiz Stefano 
Published: January 2016

Le xvii e siècle, déjà considéré comme un petit âge d’or de l’éloquence sacrée, connaît également le développement de l’éloquence juridique. C’est le moment où un débat se développe sur la valeur respective de l’une et de l’autre et, surtout, de l’une (barreau) par rapport à l’autre (chaire). Pour y parvenir, des lieux d’apprentissage commun existent, telle l’Académie des orateurs de Richesource à Paris. C’est à l’occasion d’une séance publique de l’académie qu’une question est posée : est-ce que l’éloquence de la chaire est plus difficile que celle du barreau ? L’analyse des argumentaires affrontés dévoile un espace de réflexion situé entre rivalité et complémentarité de ces deux grands genres éloquents.
Les consultations avant l’adoption
Authors: de Monléon Jean-Vital 
Published: January 2016

Pratique aujourd’hui en décroissance, l’adoption internationale concerne fréquemment des enfants atteints de problèmes de santé plus ou moins lourds. D’où l’émergence d’une forte demande de conseils médicaux, chez les parents candidats à l’adoption, à l’origine des récentes « consultations pédiatriques avant adoption ». Un exercice particulièrement délicat, exigeant du praticien la mise en œuvre de repères éthiques à la fois clairs et solides.
Renoncer à être traître
Authors: Terrier Marie-Claire 
Published: January 2016

Résumé	La fin de l’analyse permet d’aborder l’au-delà de la castration et ouvre ainsi à chacun qui s’y risque la possibilité de s’inscrire dans l’un ou dans l’autre sexe sans trahir ce que son analyse lui a permis de conclure. On questionnera, à partir du mythe celte de la Déesse blanche, ce qui reste au sujet de sa préhistoire : son sinthome, issu de la mise en fonction par la femme de mère de sa jouissance féminine en deçà de sa jouissance phallique. Quelle est la place de la poésie pour que le sujet ne s’égare pas ?
Tentatives de feindre l’impossible et « faire désirer »
Authors: Tigirlas Luminitza Claudepierre 
Published: January 2016

Résumé	L’oscillation entre l’âmoureuse et les étendues psychiques où se cultive le désir de désir de l’insatisfaction ne trouve pas de repos chez certains sujets et conduit à l’impossible logique du faire désirer. Peut-on le feindre par la fiction lyrique ? La poétesse russe Marina Tsvetaïeva – l’Aimante par son nom de sinthome –, les analysantes de Lacan et la dite Aurore s’emploient chacune dans son style aux tentatives de faire désirer via l’écriture.
Du bien-dire et du réel dans la psychanalyse
Authors: Chatelard Daniela 
Published: January 2016

Résumé	Pour toucher au réel dans la psychanalyse, nous partirons de la notion de lalangue, en passant par la réinterprétation analytique à partir d’une reprise en considération du terme de Bedeutung. Ensuite, nous passerons à l’au-delà de l’Œdipe pour arriver à ce qui échapperait à l’interprétation, c’est-à-dire à l’ininterprétable, enfin, à l’acte. Pour autant, nous ferons aussi un bref détour par le père réel, celui qui a fonction d’exception de l’universel de la fonction phallique.
Le sexe incertain… et le corps ?
Authors: Mahé Lucie , Ramos Carlos 
Published: January 2016

Résumé	L’approche du corps à partir des trois registres de J. Lacan permet de saisir la question de la subjectivation sexuelle. Cette sexuation se caractérise par le malentendu produit à partir du constat organique. Le corps sera capté dans le miroir et interrogé par la jouissance et le langage, par la lalangue. L’objet indéterminé de la pulsion et le sexe incertain amènent à articuler le choix du sexe et son objet : le corps s’y prend. Entre être et avoir, le sujet pourra se reconnaître d’un sexe ou de l’autre, là où se joue une perte nécessaire liée à la privation.
La clinique infantile : choix du sexe, choix de jouissance
Authors: Pelegrí Matilde 
Published: January 2016

Résumé	Le choix du sexe ne dépend ni de l’anatomie ni d’un déterminisme social. C’est une énigme pour chaque sujet et c’est le résultat d’un long processus singulier. En nous appuyant sur les élaborations de Freud concernant l’Œdipe et sur les formules de la sexuation de Lacan, nous aborderons quatre cas cliniques qui nous montrent les avatars de ce choix au-delà des identifications et comment, en tant que psychanalyste, nous devons accompagner ces sujets, enfants et adolescents.
Discours capitaliste et répétition
Authors: Papatheodorou Panos 
Published: January 2016

Résumé	Comment le discours capitaliste opère-t-il sur la subjectivité de notre époque ? La répétition est le lieu privilégié où le discours capitaliste prend son effet, effaçant toute tentative du sujet de se repérer dans l’acte de répétition de son symptôme.
Symptôme et sinthome, 4 e partie. Le symptôme dans la seconde topique (Freud, 1920-1939)
Authors: Guillen Fabienne 
Published: January 2016

Résumé	La seconde topique marque un tournant majeur dans la conception que se fait Freud de l’appareil psychique et de son fonctionnement qui retentit sur son idée du symptôme. Sa remise à l’honneur du concept de défense diversifie les modes de négation du sujet confronté à la castration et précise les diverses modalités de formation des symptômes. Enfin, toute analyse se heurte à l’impossible éradication du symptôme qui vient s’échouer sur le roc de la castration.
Chances de vie et risques de mort de notre planète : le combat contre l’hydre bancaire mondiale
Authors: Morin François 
Published: January 2016

Résumé	Notre planète s’est transformée brutalement depuis deux décennies avec notamment la globalisation des marchés monétaires et financiers. Il en résulte des instabilités, des crises et nombre de pathologies toujours plus graves. Au cœur de ce processus mortifère se niche l’hydre des plus grandes banques mondiales dont l’action doit être considérée comme dévastatrice.
The Boy’s Froissart de Lanier ou la réappropriation d’une mémoire européenne à destination des garçons en Amérique
Authors: Victorin Patricia 
Published: January 2016

Pourquoi Sidney Clopton Lanier juge-t-il bon, peu après la guerre de Sécession, d’écrire un livre à destination d’un jeune lectorat masculin américain dans lequel il adapte les Chroniques de Froissart, chroniqueur du xive siècle qui a relaté en son temps la guerre de Cent Ans ? Nous tenterons de comprendre les liens que Lanier tisse entre l’Europe et l’Amérique, et de cerner tout particulièrement le rôle fondateur que jouent Caxton et Lord Berners qui ont permis de faire connaître Froissart aux Anglais. L’objet principal de cette contribution est de retisser le fil ou lignage qui mène de Froissart à Sidney Clopton Lanier, de l’Europe au Vieux Sud, en passant par deux figures emblématiques des xve et xvie siècles anglais, Caxton et Lord Berners qui permettent d’enraciner le jeune lecteur américain dans le terreau d’ancêtres prestigieux.