bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Monoclonal Antibody Usage on Hearing Outcomes: A Systematic Review
Authors: Arya Priya , Salmerón Yansy , Quimby Alexandra E. , Wong Kevin , Brant Jason A. , Hwa Tiffany P. 
Published: September 2024

ObjectiveTo ascertain trends in ototoxicity observed with monoclonal antibodies (mABs) and understand the impact they may have on hearing function.Data SourcesPubMed, Embase, Scopus.Review MethodsA systematic review was performed following PRISMA guidelines. Data were reviewed for demographics, utilized mABs with respective indication and dosing, audiometric outcomes, and treatment for otologic effects.ResultsOf 757 studies reviewed, a total of 44 were included, encompassing 18,046 patients treated with mABs. Mean age of the sample was 57.8 years old. The search yielded 18 agents of ototoxicity, with reported symptoms of ototoxicity such as hearing loss, tinnitus, and/or aural fullness occurring in 1079 of total patients. Main agents causing ototoxicity were teprotumumab (n = 17/44 studies), nivolumab (n = 10/44), ipilimumab (n = 9/44), pembrolizumab (n = 5/44), and rituximab (n = 4/44). Thirty‐one of 44 studies encompassing eight agents reported audiometric data for ototoxic agents, showing sensorineural hearing loss primarily in the high‐frequency range. Only two articles performed ultrahigh‐frequency audiograms.ConclusionMonoclonal antibody usage is expanding, but the vast majority of studies lack substantial audiometric data. Where reported, study design and inclusion criteria vary greatly. Future studies would benefit from rigid inclusion of audiometric data, prospective study design, and consideration of formal ototoxicity screening. Otolaryngologists should be aware of the cochlear immune response and potential impact of this expanding medication class on hearing function. Laryngoscope, 135:491–506, 2025
Lessons for a learning health system: Effectively communicating to patients about research with their health information and biospecimens
Authors: Spector‐Bagdady Kayte , Ryan Kerry A. , Chen Luyun , Giacobone Camille , Jagsi Reshma , Hamasha Reema , Hendy Katherine , Thomas J. Denard , Milne Jessie M. , Vinson Alexandra H. , Platt Jodyn 
Published: September 2024

AbstractIntroductionSharing patient health information and biospecimens can improve health outcomes and accelerate breakthroughs in medical research. But patients generally lack understanding of how their clinical data and biospecimens are used or commercialized for research. In this mixed methods project, we assessed the impact of communication materials on patient understanding, attitudes, and perceptions.MethodsMichigan Medicine patients were recruited for a survey (n = 480) or focus group (n = 33) via a web‐based research study portal. The survey assessed the impact of mode of communication about health data and biospecimen sharing (via an informational poster vs. a news article) on patient perceptions of privacy, transparency, comfort, respect, and trust. Focus groups provided in‐depth qualitative feedback on three communication materials, including a poster, FAQ webpage, and a consent form excerpt.ResultsAmong survey respondents, the type of intervention (poster vs. news) made no statistically significant difference in its influence on any characteristic. However, 95% preferred that Michigan Medicine tell them about patient data and biospecimen research sharing versus hearing it from the news. Focus group participants provided additional insights, discussing values and perceptions of altruism and reciprocity, concerns about commercialization, privacy, and security; and the desire for consent, control, and transparency.ConclusionDeveloping our understanding of patient data‐sharing practices and integrating patient preferences into health system policy, through this work and continued exploration, contributes to building infrastructure that can be used to support the development of a learning health system across hospital systems nationally.
Preparation, Structural Analysis, and Growth‐Promoting Effects of Amomum longiligulare Polysaccharide 1‐Mg (II) Complex
Authors: Chen Yijing , Wu Haowen , Zhang Chenglong , Luo Qiyuan , Chen Yun 
Published: September 2024

AbstractIn this study, Amomum longiligulare polysaccharide 1 (ALP1) is used to chelate with magnesium (Mg) to synthesize the ALP1‐Mg (II) complex (ALP1‐Mg). Based on Box‐Behnken response surface design, the optimum technological conditions are 22 mg mL−1 trisodium citrate, 2.10 mol L−1 MgCl2, reaction at 70 °C for 2.9 h, resulting in a maximum Mg content of 2.13%. Next, the physicochemical properties and structural characteristics of ALP1 and ALP1‐Mg are characterized, and the results show that the morphology, conformation, crystallinity, and thermal stability of ALP1‐Mg are changed. In addition, dietary supplementation of 500 mg kg−1 ALP1‐Mg significantly reduces the feed conversion ratio during the grower (15–35 d). Meanwhile, the villus height/crypt depth of the duodenum and ileum are significantly increased, and the relative abundance of Lactobacillus is significantly elevated. Taken together, the results suggest that ALP1‐Mg is a potential growth‐promoting feed additive.
Potential of the Thoracoepigastric Vein as a Drainage Vein in Breast Reconstruction With a Free Flap: An Anatomical Study Using Computed Tomography
Authors: Nemoto Hitoshi , Nakatsuka Kengo , Morita Daiki , Seki Yukio , Imagawa Kotaro , Tsunoda Yotaro , Komaba Chieko , Hanai Ushio 
Published: September 2024

ABSTRACTBackgroundThe recipient vessel choice is very important when performing free‐flap breast reconstructions. Usually, the concomitant vein of the recipient artery is anastomosed, and mismatches in the diameter are occasionally observed. We consider the thoracoepigastric vein (TEV) as a potential useful recipient vein. The use of the TEV is not a novel technique. It has been used by surgeons for free‐flap anastomoses in the axillary region, but usually as an anastomotic site for the second vein. However, anatomical findings such as TEV diameter, its deficiency rate, and influence on mastectomy are not clear. In this study, computed tomography (CT) was performed to evaluate the use of the TEV as a recipient vein for breast reconstruction.MethodsThe medical records of patients who underwent breast reconstruction with free‐flap transfer were retrospectively evaluated. In most cases, CT was performed using a tissue expander inserted after mastectomy. The TEV was considered suitable if its diameter on the mastectomy side was >1 mm and the vertical distance from the most distal slice level where the TEV could be seen at the third costal cartilage height of the parasternal region was <50 mm.ResultsSixty‐six sides of 33 patients were evaluated. The mean age of the patients was 49.3 ± 5.1 years. The TEV was used in five flaps. TEV diameters were not significantly different between the left and right sides (1.85 ± 0.53 vs. 1.82 ± 0.6, respectively, p = 0.836). On the mastectomy side, eight (25%) TEVs were injured, but only three (8.6%) were considered unavailable. On the healthy side, 96.4% TEVs were available.ConclusionsTEVs may be a good choice as vein anastomosis targets for breast reconstruction with a free flap because of their relatively large vessel diameter.Trial RegistrationUMIN‐CTR: R000061573
Attitudes and Beliefs Toward Non‐Specific Neck Pain Among Physiotherapists in Jordan: A Cross‐Sectional Study
Authors: Etoom Mohammad , Banibakkar Elham , Abdullahi Auwal , Jahan Alhadi M. 
Published: September 2024

ABSTRACTBackgroundPhysiotherapists' attitudes and beliefs play a crucial role in the management and treatment outcomes of non‐specific neck pain (NSNP).ObjectiveTo investigate the attitudes and beliefs of physiotherapists in Jordan towards NSNP, and to identify factors influencing these attitudes and beliefs.MethodsA Cross‐sectional survey of registered physiotherapists working in Jordan was conducted. A structured questionnaire was used to assess the attitudes and beliefs of physiotherapists towards NSNP. Descriptive and inferential statistics were used.ResultsA total of 301 PTs completed the survey, 155 females (51.56%). Most respondents held bachelor's degrees, with an average of 9.5 ± 6.6 experience years. The total score for PABS‐PT (Z = 11.4, p < 0.001) and its BM (Z = +11.9, p < 0.001) and PS (Z = 3.6, p < 0. 001) subscales were significantly positive. The score of the biomedical subscale was more significantly positive than psychosocial subscale. The treatment orientation was positively correlated with education level, and negatively with age and experience. The most reported treatments were manual therapy followed by general exercises and electrical modalities. No significant relationship was observed between treatment orientation and treatment selection.ConclusionThis study created the initial profile for pain attitudes and beliefs in Jordan. Physiotherapists hold positive attitudes and beliefs towards the NSNP treatment orientations with a superiority of the BM approach. Engaging educational sectors and stakeholders in the current situation of PTs' attitudes and beliefs is important.
Hypogammaglobulinemia and infection risk in myotonic dystrophy type 1
Authors: El‐Wahsh Shadi , Morris Katrina , Limaye Sandhya , Riminton Sean , Corbett Alastair , Triplett James D. 
Published: September 2024

AbstractIntroduction/AimsHypogammaglobulinemia is a common yet under‐recognized feature of myotonic dystrophy type 1 (DM1). The aims of our study were to determine the frequency of immunoglobulin G (IgG) deficiency in our cohort, to examine the association between immunoglobulin levels and cytosine–thymine–guanine (CTG) repeat length in the DMPK gene, and to assess whether IgG levels are associated with an increased risk of infection in DM1 patients.MethodsWe conducted a single‐center, retrospective cross‐sectional study of 65 adult patients with DM1 who presented to the Neuromuscular Clinic at Concord Repatriation General Hospital, Sydney, Australia, between January 2002 and January 2022. We systematically collected and analyzed clinical, laboratory, and genetic data for all patients with available serum electrophoresis and/or IgG level results.ResultsForty‐one percent of DM1 patients had IgG deficiency despite normal lymphocyte counts, IgA, IgM, and albumin levels. There was an association between CTG repeat expansion size and the degree of IgG deficiency (F = 6.3, p = .02). There was no association between IgG deficiency and frequency of infection in this group (p = .428).DiscussionIgG deficiency is a frequent occurrence in DM1 patients and is associated with CTG repeat expansion size. Whether hypogammaglobulinemia is associated with increased infection risk in DM1 is unclear. A prospective multicenter cohort study is needed to evaluate this.
Anxiolytic and sedative effects of sodium valproate with different experimental paradigms in male and female rats
Authors: de los Ángeles Cintado María , De la Casa Luis Gonzalo , González Gabriel 
Published: September 2024

AbstractValproic acid or sodium valproate is a widely used drug in the treatment of epilepsy, although it also appears to have anxiolytic and sedative properties derived from its agonistic action on the GABAergic system. To analyze these potential effects of the drug, we conducted three experiments with rats using procedures designed to assess anxiety in rodents. In the first experiment, with a fear conditioning procedure, three groups of male rats were included that received either 100 mg/kg or 300 mg/kg of valproate or an equivalent volume of saline solution. In Experiment 2, recording spontaneous activity in an open field, we compared the effects of valproic acid (300 mg/kg) on male and female rats. In the third experiment, we analyzed the effect of valproic acid using a novelty‐induced hypophagia test and tested again for potential differences as a function of the sex of the animals. The results showed an anxiolytic effect restricted to the 300 mg/kg dose of the drug in Experiment 1. Such an effect was restricted to the female sample in Experiment 2, but in the third experiment affected both sexes. As for the sedative effect, it was observed in all experiments irrespective of the sex of the rats. These findings hold significant implications for the treatment of anxiety disorders since valproate may offer a novel therapeutic approach for anxiety‐related conditions with distinct benefits and fewer side effects. However, clinical studies are needed to validate the translation of these findings from animal models to human patients.
Role, education, policies and competencies for advanced practice in paediatric haematology‐oncology nursing in Europe: A scoping review
Authors: Amicucci Matteo , Trigoso Eugenia , Nori Mariagrazia , Colomer‐Lahiguera Sara , Rostagno Elena , Biagioli Valentina , Sansone Vincenza , Zibaldo Andrea , Mastria Andrea , Partel Moreno Crotti , Canesi Marta , Schiopu Andreea Cristina , Dall'Oglio Immacolata 
Published: September 2024

AbstractThe aim of this scoping review is to describe the role, education, policies/regulation, skills and competencies required for advanced practice in paediatric haematology‐oncology nursing in Europe, highlighting the differences in development between the different European countries. A scoping review was conducted following the methodological framework of guidelines by Arksey and O'Malley and the recommendations for advancing the methodology by Levac et al. We searched MEDLINE/PubMed, EMBASE, CINAHL, Cochrane Library, Scopus, grey literature, webpages, reference lists and performed a manual search, without any restrictions on language or time. The intersection between databases, grey literature and evidence documents traced from the sites of the most authoritative European organisations in the field made it possible to identify the regulatory and training differences between the various countries that were examined. This scoping review highlights how advanced knowledge and competences are used in the care of paediatric haematology‐oncology patients, which are strictly necessary for implementing quality care. At present these competences are not recognised in policies and regulation in most of the countries that were examined. It is desirable that all EU member states work to implement a radical change and allow these more competent figures to assist patients in the best possible way.
Investigation on damage behaviors of carbon fiber‐reinforced nylon 6 thermoplastic composite laminates using acoustic emission and digital image correlation techniques
Authors: Zhu Jixin , Hu Kejun , Han Wenqin , Shi Qinghe , Wang Yingming , Zhao Fengling , Zhu Fuxian 
Published: September 2024

AbstractThe objective of this paper is to analyze the mechanical properties and damage mechanisms of carbon fiber‐reinforced polyamide thermoplastic composite laminates. Four specimens with different ply orientations were designed for open‐hole tensile experiments, and interlaminar toughness experiments including double cantilever beam and end‐notched flexural were carried out. The experimental process was monitored synchronously using acoustic emission, and the strain field changes of the tensile specimens were captured using digital image correlation technology. The unsupervised clustering of the peak frequencies of the acoustic emission signals based on the K‐means++ algorithm was employed to ascertain the peak frequency ranges corresponding to the various damage modes. Typical signals from different specimens were selected, and the gray wolf algorithm was used to optimize the variational modal parameters to decompose the signals. The waveform characteristics, frequency components, and Hilbert spectra of each damage mode were given. The correlation analysis of the intrinsic mode function (IMF) components of the same damage in different specimens demonstrated that the IMF components exhibited high similarity. By analyzing the time series changes in the energy of each damage mode in different specimens, the contribution of different damage modes to the evolution of laminated plate damage was evaluated.Highlights
The mechanical properties of CF/PA6 laminates were investigated based on open‐hole tensile specimens and pre‐cracked delamination specimens.
Unsupervised clustering of AE peak frequencies using K‐means++ to establish the relationship between peak frequencies and damage patterns.
AE counts and cumulative energy were used to assess damage evolution.
By identifying a single damage signal and providing a more intuitive treatment of the damage energy evolution.
Hygrothermal aging effects on the mechanical behaviors of twill‐woven carbon fiber composite laminates with flame‐retardant epoxy resin
Authors: Zhong Jinru , Ma Junwei , Sun Weikang , Lei Zuxiang , Yin Binbin 
Published: September 2024

AbstractComposite structures are frequently exposed to varying hygrothermal environments, which can lead to the deterioration of their mechanical properties. This study explores the effects of hygrothermal aging on the mechanical behaviors of twill‐woven carbon fiber composite laminates, with a particular focus on laminates with flame‐retardant epoxy resin (CF_FR)—a relatively underexplored area. The findings reveal several key insights: (1) CF_FR exhibit more pronounced aging damage compared to those with general epoxy resin (CF_G), primarily due to higher moisture absorption, which results in increased surface swelling and internal delamination. (2) Hygrothermal aging enhances the impact resistance of both types of laminates by increasing peak force, particularly at higher temperatures, thereby reducing impact‐induced damage. (3) CF_FR suffers greater reductions in compressive and compression after impact (CAI) strength following aging, with CAI strength decreasing by 36.3% for flame‐retardant laminates and 14.8% for CF_G after immersion at 70°C. (4) Significant local buckling is observed in the swollen regions of CF_FR under compressive loading, indicating an heightened vulnerability to structural instability after aging. These findings offer valuable insights into the performance of composite materials under prolonged moisture exposure, particularly in safety‐critical applications where both flame retardancy and mechanical integrity are crucial.Highlights
More aging damage is captured from laminates with flame‐retardant epoxy resin
Aging temperatures alleviate LVI induced damage and improve the peak force
Compressive and CAI strength are affected after prolonged aging conditions
CAI strength of CF_FR decreases by 36.3% after exposure to the 70°C water bath
Significant local buckling is observed in CF_FR under compressive loading
Perioperative hemodynamic parameters monitored by three noninvasive technologies in children with congenital heart disease: A prospective study
Authors: Xiong Xiaoyu , Xu Feng , Qiu Wei , Li Shaojun , Liu Chengjun 
Published: September 2024

AbstractThis study aims to compare the efficiencies of three noninvasive technologies in monitoring the perioperative hemodynamics of children with congenital heart disease (CHD) including ventricular septal defects with or without atrial septal defects. Three noninvasive technologies included transthoracic echocardiography (TTE), electrical cardiometry (EC), and vasoactive inotropic score (VIS). Parameters included left ventricular ejection fraction (LVEF) and cardiac index (cardiac index monitored by ultrasound, uCI) in TTE, cardiac index (cardiac index monitored by electrical cardiometry, eCI) and systemic vascular resistance index (SVRI) in EC, and VIS. Seventy‐four children were eligible. Three types of adverse events (AEs) related to disease activity and prognosis were observed, including cardio‐pulmonary resuscitation in five cases (5/74, 6.76%), hypoxic‐ischemic brain damage in four cases (4/74, 5.41%) and hemopurification in four cases (4/74, 5.41%). Except for LVEF, eight parameters (VISmax [maximum VIS], VISmea [mean VIS], uCImea [mean uCI], uCImin [minimum uCI], eCImea [mean eCI], eCImin [minimum eCI], SVRImea [mean SVRI], and SVRImin [minimum SVRI]) showed predictive value for any AE (p < 0.05). VISmea, uCImea, and eCImea demonstrated the highest accuracy and linear associations (AUROC > 0.9, p = 0.00). Linear associations also existed between the three groups of parameters and the duration of mechanical ventilation (MV) and the length of stay (LOS) in the intensive care unit (ICU). The duration of MV and the LOS in the ICU increased as VISmea rose, or uCImea and eCImea fell (p < 0.05). LVEF in TTE could not predict any AE (p > 0.05) and not fully reflect the cardiovascular function. Therefore, most parameters obtained in TTE, EC, and VIS can reflect the perioperative hemodynamics of children with CHD, with VISmea, uCImea, and eCImea being most accurate.
PLA/CB and HDPE/CB conductive polymer composites: Effect of polymer matrix structure on the rheological and electrical percolation threshold
Authors: Pê Filipe R. , Rodrigues Túlio A. C. S. , da Cunha Rafael B. , Cavalcanti Shirley N. , da Silva Moacy P. , Agrawal Pankaj , Brito Gustavo F. , de Mélo Tomás J. A. 
Published: September 2024

AbstractIn this study, the effect of the polymer matrix structure on the rheological and electrical percolation threshold of polymer/carbon black (CB) conductive polymer composites (CPCs) was investigated. Poly(lactic acid) (PLA) and high‐density polyethylene (HDPE) were used as polymer matrices. Through rheological analyses, an increase in complex viscosity was observed with increasing CB concentration, accompanied by a reduction in the Newtonian plateau. Additionally, an increase in the solid‐like behavior was observed, suggesting the formation of a percolated network. The rheological percolation threshold was found to be 5.13% CB mass fraction for the PLA/CB composite and 10.72% for the HDPE/CB composite. Electrical conductivity results were fitted to the sigmoidal Boltzmann model, and its derivative was used to identify the electrical percolation threshold. For PLA/CB, this threshold was reached at 5.39% CB mass fraction, while for HDPE/CB, it occurred at 5.75%. Morphology analysis by scanning electron microscopy and atomic force microscopy indicated that the polymer matrix structure affected the distribution/dispersion of the CB particles within the polymer matrix.Highlights
The effect of polymer matrix structure on polymer/CB CPCs was investigated.
The crystallinity of the polymer matrix affected the percolation threshold.
PLA/CB showed higher conductivity than HDPE/CB CPCs.