bluuebunny/crossref_metadata_2025_split huggingface dataset:
Craft Beer in the United States: History, Numbers, and Geography
Authors: Elzinga Kenneth G. , Tremblay Carol Horton , Tremblay Victor J. 
Published: December 2015

AbstractWe provide a mini-history of the craft beer segment of the U.S. brewing industry with particular emphasis on producer-entrepreneurs but also other pioneers involved in the promotion and marketing of craft beer who made contributions to brewing it. In contrast to the more commodity-like lager beer produced by the macrobrewers in the United States, the output of the craft segment more closely resembles the product differentiation and fragmentation in the wine industry. We develop a database that tracks the rise of craft brewing using various statistical measures of output, number of producers, concentration within the segment, and compares output with that of the macro and import segment of the industry. Integrating our database into Geographic Information Systems software enables us to map the spread of the craft beer segment from its taproot in San Francisco across the United States. Finally, we use regression analysis to explore variables influencing the entrants and craft beer production at the state level from 1980 to 2012. We use Tobit estimation for production and negative binomial estimation for the number of brewers. We also analyze whether strategic effects (e.g., locating near competing beer producers) explain the location choices of craft beer producers. (JEL Classifications: L26, L66, N82, R12)
The Veldwezelt site (province of Limburg, Belgium): environmental and stratigraphical interpretations
Authors: Meijs E.P.M. 
Published: December 2015

AbstractUphill and drainage line environments reveal many hiatuses or discordances, because of truncation by erosion. In downslope position accumulation often prevailed outside the drainage lines and prevented erosion, even during unstable periods. Consequently, downslope sections yield the most detailed environmental data, but often lack contact with uphill series. However, for stratigraphical correlation the contact between downslope and uphill series is essential. In the Veldwezelt loess sequence this contact is intact, which provides additional data on transitional processes. In view of these special palaeoenvironmental conditions, exhibiting a transition between downslope and uphill areas and a south-east trending stream, an extraordinarily detailed Late Saalian, Eemian and Weichselian loess sequence could be reconstructed. The Veldwezelt series furnished important pedological, sedimentological, faunal, tephrochronological and cryogenic data, on the basis of which palaeoenvironmental conclusions could be drawn and six types of pedo-sedimentological cycles distinguished. A stratigraphical overview was obtained by correlating the Veldwezelt section with other west European loess frameworks and tephra sequences; the sedimentary series at Harmignies (Mons Basin, southern Belgium) and the Greenland GRIP ice core.
Risk Perceptions and Management Responses: Producer-Generated Hypotheses For Risk Modeling
Authors: Patrick George R. , Wilson Paul N. , Barry Peter J. , Boggess William G. , Young Douglas L. 
Published: December 2015

AbstractFarm level risk analyses have used price and yield variability almost exclusively to represent risk. Results from a survey of 149 agricultural producers in 12 states indicate that producers consider a broader range of sources of variability in their operations. Significant differences exist among categories with respect to the importance of the sources of variability in crop and livestock production. Producers also used a variety of management responses to variability. There were significant difference among categories in the importance given to particular responses and their use of them. These results have implications for research, extension, and policy programs.
Hedonic Estimation Applied to the Farmland Market in Georgia
Authors: Elad R.L. , Clifton I.D. , Epperson J.E. 
Published: December 2015

AbstractFarmland offered for its productive or consumptive value may be viewed as a class of goods characteristic of product differentiation. Using the generalized Box-Cox transformation, an unrestricted hedonic model was employed to derive implicit valuations of parcel attributes. Results suggest that the significance and level of importance of attributes on land pricing depends on the spatial extent of markets in Georgia. Differences in the productive or consumptive use of farmland may imply that different factors and functional forms are appropriate to different farmland markets.
Neurorobiology and Evidence-Based Biological Treatments for Substance Abuse Disorders
Authors: Ivanov Iliyan S. , Schuiz Kurt P. , Palmero Robyn C. , Newcorn Jeffrey H. 
Published: December 2015

ABSTRACTBehavioral patterns of addiction include compulsive drug-seeking, persistent abuse of substances despite the often dire consequences on social functioning and physical health, and the high probability of relapse even after prolonged drug-free periods.The recent focus on the biological basis of addiction has provided evidence to support the hypothesis that behavioral manifestations for addiction are influenced by biological factors, and biological factors often produce behavioral changes that can further increase risk. The current understanding of the role of the dopaminergic, glutamatergic, γ-aminobutyric acidergic, and opioid receptor systems in the pathophysiology of addiction as well as the clinical implications of these systems for new and emerging treatments will be discussed. This article will also review the pharmacologic agents used in the treatment of substance abuse disorders and presents evidence-based data for their safety, efficacy, and feasibility of use in different patient populations.
Multilingual native language identification
Authors: MALMASI SHERVIN , DRAS MARK 
Published: December 2015

AbstractWe present the first comprehensive study of Native Language Identification (NLI) applied to text written in languages other than English, using data from six languages. NLI is the task of predicting an author’s first language using only their writings in a second language, with applications in Second Language Acquisition and forensic linguistics. Most research to date has focused on English but there is a need to apply NLI to other languages, not only to gauge its applicability but also to aid in teaching research for other emerging languages. With this goal, we identify six typologically very different sources of non-English second language data and conduct six experiments using a set of commonly used features. Our first two experiments evaluate our features and corpora, showing that the features perform well and at similar rates across languages. The third experiment compares non-native and native control data, showing that they can be discerned with 95 per cent accuracy. Our fourth experiment provides a cross-linguistic assessment of how the degree of syntactic data encoded in part-of-speech tags affects their efficiency as classification features, finding that most differences between first language groups lie in the ordering of the most basic word categories. We also tackle two questions that have not previously been addressed for NLI. Other work in NLI has shown that ensembles of classifiers over feature types work well and in our final experiment we use such an oracle classifier to derive an upper limit for classification accuracy with our feature set. We also present an analysis examining feature diversity, aiming to estimate the degree of overlap and complementarity between our chosen features employing an association measure for binary data. Finally, we conclude with a general discussion and outline directions for future work.
Developing a performance framework for measuring comprehensive, community-based primary healthcare for people with HIV
Authors: Johnston Sharon , Hogel Matthew , Burchell Ann N. , Rebick Gabriel , Antoniou Tony , McLaren Meaghan , Loutfy Mona , Liddy Clare , Kendall Claire 
Published: December 2015

ObjectivesPeople with human immunodeficiency virus (HIV) are living longer lives and like many other patients, need a health system better adapted for the management of complex chronic conditions. A key element of system transformation is measuring and reporting on system performance indicators relevant to the different stakeholders. Our objective was to produce a performance measurement framework for assessing the quality of comprehensive community-based primary healthcare for people with HIV.MethodsSemi-structured interviews were performed with HIV providers, advocates, and policy-makers to obtain input on a draft performance framework, constructed using existing HIV-specific indicators, as well as the use of performance data in improving care for people with HIV.ResultsStakeholders were overwhelmingly supportive of the framework’s comprehensiveness. Many noted the absence of indicators addressing social determinants of health and had mixed opinions on the importance of indicators addressing access to after-hours care and the frequency of routine screening for behavioural risk factors. The draft framework was modified to reflect stakeholder input, triangulated against expert opinion and recently released HIV care guidelines, and finalized at 79 indicators. The resources and infrastructure to collect and use performance data will have to be improved for performance measurement to contribute to improving care for people with HIV.ConclusionsThis framework presents a comprehensive though not exhaustive tool to support performance measurement and improvement in the care for people with HIV. However, advances in data collection and use across the system will be needed to support performance measurement driving quality improvement.
Broadband chirality-coded meta-aperture for photon-spin resolving
Authors: Du Luping , Kou Shan Shan , Balaur Eugeniu , Cadusch Jasper J. , Roberts Ann , Abbey Brian , Yuan Xiao-Cong , Tang Dingyuan , Lin Jiao 
Published: December 2015

AbstractThe behaviour of light transmitted through an individual subwavelength aperture becomes counterintuitive in the presence of surrounding ‘decoration’, a phenomenon known as the extraordinary optical transmission. Despite being polarization-sensitive, such an individual nano-aperture, however, often cannot differentiate between the two distinct spin-states of photons because of the loss of photon information on light-aperture interaction. This creates a ‘blind-spot’ for the aperture with respect to the helicity of chiral light. Here we report the development of a subwavelength aperture embedded with metasurfaces dubbed a ‘meta-aperture’, which breaks this spin degeneracy. By exploiting the phase-shaping capabilities of metasurfaces, we are able to create specific meta-apertures in which the pair of circularly polarized light spin-states produces opposite transmission spectra over a broad spectral range. The concept incorporating metasurfaces with nano-apertures provides a venue for exploring new physics on spin-aperture interaction and potentially has a broad range of applications in spin-optoelectronics and chiral sensing.
Transformable liquid-metal nanomedicine
Authors: Lu Yue , Hu Quanyin , Lin Yiliang , Pacardo Dennis B. , Wang Chao , Sun Wujin , Ligler Frances S. , Dickey Michael D. , Gu Zhen 
Published: December 2015

AbstractTo date, numerous inorganic nanocarriers have been explored for drug delivery systems (DDSs). However, the clinical application of inorganic formulations has often been hindered by their toxicity and failure to biodegrade. We describe here a transformable liquid-metal nanomedicine, based on a core–shell nanosphere composed of a liquid-phase eutectic gallium-indium core and a thiolated polymeric shell. This formulation can be simply produced through a sonication-mediated method with bioconjugation flexibility. The resulting nanoparticles loaded with doxorubicin (Dox) have an average diameter of 107 nm and demonstrate the capability to fuse and subsequently degrade under a mildly acidic condition, which facilitates release of Dox in acidic endosomes after cellular internalization. Equipped with hyaluronic acid, a tumour-targeting ligand, this formulation displays enhanced chemotherapeutic inhibition towards the xenograft tumour-bearing mice. This liquid metal-based DDS with fusible and degradable behaviour under physiological conditions provides a new strategy for engineering theranostic agents with low toxicity.
Structural insight into the mechanism of synergistic autoinhibition of SAD kinases
Authors: Wu Jing-Xiang , Cheng Yun-Sheng , Wang Jue , Chen Lei , Ding Mei , Wu Jia-Wei 
Published: December 2015

AbstractThe SAD/BRSK kinases participate in various important life processes, including neural development, cell cycle and energy metabolism. Like other members of the AMPK family, SAD contains an N-terminal kinase domain followed by the characteristic UBA and KA1 domains. Here we identify a unique autoinhibitory sequence (AIS) in SAD kinases, which exerts autoregulation in cooperation with UBA. Structural studies of mouse SAD-A revealed that UBA binds to the kinase domain in a distinct mode and, more importantly, AIS nestles specifically into the KD-UBA junction. The cooperative action of AIS and UBA results in an ‘αC-out’ inactive kinase, which is conserved across species and essential for presynaptic vesicle clustering in C. elegans. In addition, the AIS, along with the KA1 domain, is indispensable for phospholipid binding. Taken together, these data suggest a model for synergistic autoinhibition and membrane activation of SAD kinases.
The height limit of a siphon
Authors: Boatwright A. , Hughes S. , Barry J. 
Published: December 2015

AbstractThe maximum height of a siphon is generally assumed to be dependent on barometric pressure—about 10 m at sea level. This limit arises because the pressure in a siphon above the upper reservoir level is below the ambient pressure and when the height of a siphon approaches 10 m, the pressure at the crown of the siphon falls below the vapour pressure of water causing water to boil breaking the column. After breaking, the columns on either side are supported by differential pressure between ambient and the low-pressure region at the top of the siphon. Here we report an experiment of a siphon operating at sea level at a height of 15 m, well above 10 m. Prior degassing of the water prevented cavitation. This experiment provides conclusive evidence that siphons operate through gravity and molecular cohesion.
Towards An Advanced Graphene-Based Magnetic Resonance Imaging Contrast Agent: Sub-acute Toxicity and Efficacy Studies in Small Animals
Authors: Kanakia Shruti , Toussaint Jimmy , Hoang Dung Minh , Mullick Chowdhury Sayan , Lee Stephen , Shroyer Kenneth R. , Moore William , Wadghiri Youssef Z. , Sitharaman Balaji 
Published: December 2015

AbstractCurrent clinical Gd3+-based T1 magnetic resonance imaging (MRI) contrast agents (CAs) are suboptimal or unsuitable, especially at higher magnetic fields (>1.5 Tesla) for advanced MRI applications such as blood pool, cellular and molecular imaging. Herein, towards the goal of developing a safe and more efficacious high field T1 MRI CA for these applications, we report the sub-acute toxicity and contrast enhancing capabilities of a novel nanoparticle MRI CA comprising of manganese (Mn2+) intercalated graphene nanoparticles functionalized with dextran (hereafter, Mangradex) in rodents. Sub-acute toxicology performed on rats intravenously injected with Mangradex at 1, 50 or 100 mg/kg dosages 3 times per week for three weeks indicated that dosages ≤50 mg/kg could serve as potential diagnostic doses. Whole body 7 Tesla MRI performed on mice injected with Mangradex at a potential diagnostic dose (25 mg/kg or 455 nanomoles Mn2+/kg; ~2 orders of magnitude lower than the paramagnetic ion concentration in a typical clinical dose) showed persistent (up to at least 2 hours) contrast enhancement in the vascular branches (Mn2+ concentration in blood at steady state = 300 ppb, per voxel = 45 femtomoles). The results lay the foundations for further development of Mangradex as a vascular and cellular/ molecular MRI probe.
Using complex networks towards information retrieval and diagnostics in multidimensional imaging
Authors: Banerjee Soumya Jyoti , Azharuddin Mohammad , Sen Debanjan , Savale Smruti , Datta Himadri , Dasgupta Anjan Kr , Roy Soumen 
Published: December 2015

AbstractWe present a fresh and broad yet simple approach towards information retrieval in general and diagnostics in particular by applying the theory of complex networks on multidimensional, dynamic images. We demonstrate a successful use of our method with the time series generated from high content thermal imaging videos of patients suffering from the aqueous deficient dry eye (ADDE) disease. Remarkably, network analyses of thermal imaging time series of contact lens users and patients upon whom Laser-Assistedin situKeratomileusis (Lasik) surgery has been conducted, exhibit pronounced similarity with results obtained from ADDE patients. We also propose a general framework for the transformation of multidimensional images to networks for futuristic biometry. Our approach is general and scalable to other fluctuation-based devices where network parameters derived from fluctuations, act as effective discriminators and diagnostic markers.
Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamate Abeta 3-X
Authors: Antonios Gregory , Borgers Henning , Richard Bernhard C. , Brauß Andreas , Meißner Julius , Weggen Sascha , Pena Vladimir , Pillot Thierry , Davies Sarah L. , Bakrania Preeti , Matthews David , Brownlees Janet , Bouter Yvonne , Bayer Thomas A. 
Published: December 2015

AbstractFull-length Aβ1-42 and Aβ1-40, N-truncated pyroglutamate Aβ3-42 and Aβ4-42 are major variants in the Alzheimer brain. Aβ4-42 has not been considered as a therapeutic target yet. We demonstrate that the antibody NT4X and its Fab fragment reacting with both the free N-terminus of Aβ4-x and pyroglutamate Aβ3-X mitigated neuron loss in Tg4-42 mice expressing Aβ4-42 and completely rescued spatial reference memory deficits after passive immunization. NT4X and its Fab fragment also rescued working memory deficits in wild type mice induced by intraventricular injection of Aβ4-42. NT4X reduced pyroglutamate Aβ3-x, Aβx-40 and Thioflavin-S positive plaque load after passive immunization of 5XFAD mice. Aβ1-x and Aβx-42 plaque deposits were unchanged. Importantly, for the first time, we demonstrate that passive immunization using the antibody NT4X is therapeutically beneficial in Alzheimer mouse models showing that N-truncated Aβ starting with position four in addition to pyroglutamate Aβ3-x is a relevant target to fight Alzheimer’s disease.
Wavelength and orientation dependent capture of light by diatom frustule nanostructures
Authors: Romann Julien , Valmalette Jean-Christophe , Chauton Matilde Skogen , Tranell Gabriella , Einarsrud Mari-Ann , Vadstein Olav 
Published: December 2015

AbstractThe ecological success of diatoms is emphasized by regular blooms of many different species in all aquatic systems, but the reason behind their success is not fully understood. A special feature of the diatom cell is the frustule, a nano-patterned cell encasement made of amorphous biosilica. The optical properties of a cleaned single valve (one half of a frustule) from the diatom Coscinodiscus centralis were studied using confocal micro-spectroscopy. A photonic crystal function in the frustule was observed and analysis of the hyperspectral mapping revealed an enhancement of transmitted light around 636 and 663 nm. These wavelengths match the absorption maxima of chlorophyll a and c, respectively. Additionally, we demonstrate that a highly efficient light trapping mechanism occurred, resulting from strong asymmetry between the cribrum and foramen pseudo-periodic structures. This effect may prevent transmitted light from being backscattered and in turn enhance the light absorption. Based on our results, we hypothesize that the multi-scaled layered structure of the frustule improves photosynthetic efficiency by these three mechanisms. The optical properties of the frustule described here may contribute to the ecological success of diatoms in both lentic and marine ecosystems and should be studies further in vivo.
Defending against pathogens – immunological priming and its molecular basis in a sea anemone, cnidarian
Authors: Brown Tanya , Rodriguez-Lanetty Mauricio 
Published: December 2015

AbstractCnidarians, in general, are long-lived organisms and hence may repeatedly encounter common pathogens during their lifespans. It remains unknown whether these early diverging animals possess some type of immunological reaction that strengthens the defense response upon repeated infections, such as that described in more evolutionary derived organisms. Here we show results that sea anemones that had previously encountered a pathogen under sub-lethal conditions had a higher survivorship during a subsequently lethal challenge than naïve anemones that encountered the pathogen for the first time. Anemones subjected to the lethal challenge two and four weeks after the sub-lethal exposure presented seven- and five-fold increases in survival, respectively, compared to the naïve anemones. However, anemones challenged six weeks after the sub-lethal exposure showed no increase in survivorship. We argue that this short-lasting priming of the defense response could be ecologically relevant if pathogen encounters are restricted to short seasons characterized by high stress. Furthermore, we discovered significant changes in proteomic profiles between naïve sea anemones and those primed after pathogen exposure suggesting a clear molecular signature associated with immunological priming in cnidarians. Our findings reveal that immunological priming may have evolved much earlier in the tree of life than previously thought.
High level of inbreeding in final phase of 1000 Genomes Project
Authors: Gazal Steven , Sahbatou Mourad , Babron Marie-Claude , Génin Emmanuelle , Leutenegger Anne-Louise 
Published: December 2015

AbstractThe 1000 Genomes Project provides a unique source of whole genome sequencing data for studies of human population genetics and human diseases. The last release of this project includes more than 2,500 sequenced individuals from 26 populations. Although relationships among individuals have been investigated in some of the populations, inbreeding has never been studied. In this article, we estimated the genomic inbreeding coefficient of each individual and found an unexpected high level of inbreeding in 1000 Genomes data: nearly a quarter of the individuals were inbred and around 4% of them had inbreeding coefficients similar or greater than the ones expected for first-cousin offspring. Inbred individuals were found in each of the 26 populations, with some populations showing proportions of inbred individuals above 50%. We also detected 227 previously unreported pairs of close relatives (up to and including first-cousins). Thus, we propose subsets of unrelated and outbred individuals, for use by the scientific community. In addition, because admixed populations are present in the 1000 Genomes Project, we performed simulations to study the robustness of inbreeding coefficient estimates in the presence of admixture. We found that our multi-point approach (FSuite) was quite robust to admixture, unlike single-point methods (PLINK).