bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective Assessment of Sex‐Related Differences in Symptom Status and Health Perception Among Patients With Atrial Fibrillation
Authors: Blum Steffen , Muff Christoph , Aeschbacher Stefanie , Ammann Peter , Erne Paul , Moschovitis Giorgio , Di Valentino Marcello , Shah Dipen , Schläpfer Jürg , Fischer Andreas , Merkel Tamara , Kühne Michael , Sticherling Christian , Osswald Stefan , Conen David 
Published: July 2017

Background
We prospectively assessed sex‐specific differences in health perception, overall symptom status, and specific symptoms in a large cohort of patients with atrial fibrillation.

Methods and Results

We performed a prospective multicenter observational cohort study of 1553 patients with atrial fibrillation. Patients completed questionnaires about personal characteristics, comorbidities, and symptoms on a yearly basis. Mean age was 70±11 years among women and 67±12 years among men. Health perception on a visual analogue scale ranging from 0 to 100 (with higher scores indicating better health perception) was significantly lower in women than in men (70 [interquartile range: 50–80] versus 75 [interquartile range: 60–85];
P
<0.0001). More women than men had any symptoms (85.0% versus 68.3%;
P
<0.0001), palpitations (65.2% versus 44.4%;
P
<0.0001), dizziness (25.6% versus 13.5%;
P
<0.0001), dyspnea (35.7% versus 21.8%;
P
<0.0001), and fatigue (25.3% versus 19.1%;
P
=0.006). At 1‐year follow‐up, symptoms decreased in both sexes but remained more frequent in women (49.1% versus 32.6%,
P
<0.0001). In multivariable adjusted longitudinal regression models, female sex remained an independent predictor for lower health perception (ß=−4.8; 95% CI, −6.5 to −3.1;
P
<0.0001), any symptoms (odds ratio [
OR
]: 2.6; 95%
CI
, 2.1–3.4;
P
<0.0001), palpitations (
OR
: 2.6; 95% CI, 2.1–3.2;
P
<0.0001), dizziness (
OR
: 2.9; 95% CI, 2.1–3.9;
P
<0.0001), dyspnea (
OR
: 2.1; 95% CI, 1.6–2.8;
P
<0.0001), fatigue (
OR
: 1.6; 95% CI, 1.2–2.2;
P
=0.0008), and chest pain (
OR
: 1.8; 95% CI, 1.3–2.6;
P
=0.001).

Conclusions
Women with atrial fibrillation have a substantially higher symptom burden and lower health perception than men. These relationships persisted after multivariable adjustment and during prospective follow‐up.
El Groupe Français d´Éducation Nouvelle y la Guerra Civil española en las revistas Pour l´Ère Nouvelle y L´Éducateur Prolétarien
Authors: Lázaro Lorente Luis Miguel 
Published: July 2017

The Groupe Français d’Éducation Nouvelle (G.F.E.N.) was a fundamental point of reference for the New Education movement in Europe, represented in the interwar period by the International League for New Education. It was a diverse group, both in its composition and its ideological and pedagogical guidance, especially from 1936 with the arrival of Celestin Freinet and his co-workers from the Coopérative d’Enseignement laic. Through its magazine, Pour l’Ère Nouvelle, which was founded by Adolphe Ferrière and published regularly between January 1922 and March 1940, this movement had a significant influence on educational reformers throughout those two decades. The same is true for the magazine directed by Freinet, L’Éducateur Prolétarien – published regularly from October 1932 to March 1940, which also had a decisive influence on the most dedicated reformers in the field of education who were engaged in the transformation of the school during the emergence of the new social and political order. From 1936 onwards, the drama of the Spanish Civil War prompted the mobilisation of important and influential sectors of intellectuals and French educators in a broad progressive movement of solidarity with the Spanish Republic. This paper aims to analyse how this conflict, in particular its educational and humanitarian aspects, was represented editorially in the two most influential journals linked more or less directly to G.F.E.N.: Pour l’Ère Nouvelle and L’Éducateur Prolétarien. The plurality of the G.F.E.N. is reflected in how that conflict was dealt with in both journals.
Orkambi® and amplifier co‐therapy improves function from a rare CFTR mutation in gene‐edited cells and patient tissue
Authors: Molinski Steven V , Ahmadi Saumel , Ip Wan , Ouyang Hong , Villella Adriana , Miller John P , Lee Po‐Shun , Kulleperuma Kethika , Du Kai , Di Paola Michelle , Eckford Paul DW , Laselva Onofrio , Huan Ling Jun , Wellhauser Leigh , Li Ellen , Ray Peter N , Pomès Régis , Moraes Theo J , Gonska Tanja , Ratjen Felix , Bear Christine E 
Published: July 2017

AbstractThe combination therapy of lumacaftor and ivacaftor (Orkambi®) is approved for patients bearing the major cystic fibrosis (CF) mutation: ΔF508. It has been predicted that Orkambi® could treat patients with rarer mutations of similar “theratype”; however, a standardized approach confirming efficacy in these cohorts has not been reported. Here, we demonstrate that patients bearing the rare mutation: c.3700 A>G, causing protein misprocessing and altered channel function—similar to ΔF508‐CFTR, are unlikely to yield a robust Orkambi® response. While in silico and biochemical studies confirmed that this mutation could be corrected and potentiated by lumacaftor and ivacaftor, respectively, this combination led to a minor in vitro response in patient‐derived tissue. A CRISPR/Cas9‐edited bronchial epithelial cell line bearing this mutation enabled studies showing that an “amplifier” compound, effective in increasing the levels of immature CFTR protein, augmented the Orkambi® response. Importantly, this “amplifier” effect was recapitulated in patient‐derived nasal cultures—providing the first evidence for its efficacy in augmenting Orkambi® in tissues harboring a rare CF‐causing mutation. We propose that this multi‐disciplinary approach, including creation of CRISPR/Cas9‐edited cells to profile modulators together with validation using primary tissue, will facilitate therapy development for patients with rare CF mutations.
Poincare series for the algebras of joint invariants and covariants of $n$ quadratic forms
Authors: Ilash N.B. 
Published: July 2017

We consider one of the fundamental problems of classical invariant theory - the research of Poincare series for an algebra of invariants of Lie group $SL_2$. The first two terms of the Laurent series expansion of Poincare series at the point $z = 1$ give us important information about the structure of the algebra $\mathcal{I}_{d}.$ It was derived by Hilbert for the algebra ${\mathcal{I}_{d}=\mathbb{C}[V_d]^{\,SL_2}}$ of invariants for binary $d-$form (by $V_d$ denote the vector space over $\mathbb{C}$ consisting of all binary forms homogeneous of degree $d$). Springer got this result, using explicit formula for the Poincare series of this algebra. We consider this problem for the algebra of joint invariants $\mathcal{I}_{2n}=\mathbb{C}[\underbrace{V_2 \oplus V_2 \oplus \cdots \oplus V_2}_{\text{n times}}]^{SL_2}$ and the algebra of joint covariants $\mathcal{C}_{2n}=\mathbb{C}[\underbrace{V_2 {\oplus} V_2 {\oplus} \cdots {\oplus} V_2}_{\text{n times}}{\oplus}\mathbb{C}^2 ]^{SL_2}$ of $n$ quadratic forms. We express the Poincare series $\mathcal{P}(\mathcal{C}_{2n},z)=\sum_{j=0}^{\infty }\dim(\mathcal{C}_{2n})_{j}\, z^j$ and $\mathcal{P}(\mathcal{I}_{2n},z)=\sum_{j=0}^{\infty }\dim(\mathcal{I}_{2n})_{j}\, z^j$ of these algebras in terms of Narayana polynomials. Also, for these algebras we calculate the degrees and asymptotic behavious of the degrees, using their Poincare series.
Parabolic systems of Shilov-type with coefficients of bounded smoothness and nonnegative genus
Authors: Litovchenko V.A. , Unguryan G.M. 
Published: July 2017

The Shilov-type parabolic systems are parabolically stable systems for changing its coefficients unlike of parabolic systems by Petrovskii. That's why the modern theory of the Cauchy problem for class by Shilov-type systems is developing abreast how the theory of the systems with constant or time-dependent coefficients alone. Building the theory of the Cauchy problem for systems with variable coefficients is actually today. A new class of linear parabolic systems with partial derivatives to the first order by the time $t$ with variable coefficients that includes a class of the Shilov-type systems with time-dependent coefficients and non-negative genus is considered in this work. A main part of differential expression concerning space variable $x$ of each such system is parabolic (by Shilov) expression. Coefficients of this expression are time-dependent, but coefficients of a group of younger members may depend also a space variable. We built the fundamental solution of the Cauchy problem for systems from this class by the method of sequential approximations. Conditions of minimal smoothness on coefficients of the systems by variable $x$ are founded, the smoothness of solution is investigated and estimates of derivatives of this solution are obtained. These results are important for investigating of the correct solution of the Cauchy problem for this systems in different functional spaces, obtaining forms of description of the solution of this problem and its properties.
A High-Density Linkage Map Reveals Sexual Dimorphism in Recombination Landscapes in Red Deer (Cervus elaphus)
Authors: Johnston Susan E , Huisman Jisca , Ellis Philip A , Pemberton Josephine M 
Published: July 2017

Abstract
High-density linkage maps are an important tool to gain insight into the genetic architecture of traits of evolutionary and economic interest, and provide a resource to characterize variation in recombination landscapes. Here, we used information from the cattle genome and the 50 K Cervine Illumina BeadChip to inform and refine a high-density linkage map in a wild population of red deer (Cervus elaphus). We constructed a predicted linkage map of 38,038 SNPs and a skeleton map of 10,835 SNPs across 34 linkage groups. We identified several chromosomal rearrangements in the deer lineage relative to sheep and cattle, including six chromosome fissions, one fusion, and two large inversions. Otherwise, our findings showed strong concordance with map orders in the cattle genome. The sex-averaged linkage map length was 2739.7 cM and the genome-wide autosomal recombination rate was 1.04 cM/Mb. The female autosomal map length was 1.21 longer than that of males (2767.4 cM vs. 2280.8 cM, respectively). Sex differences in map length were driven by high female recombination rates in peri-centromeric regions, a pattern that is unusual relative to other mammal species. This effect was more pronounced in fission chromosomes that would have had to produce new centromeres. We propose two hypotheses to explain this effect: (1) that this mechanism may have evolved to counteract centromeric drive associated with meiotic asymmetry in oocyte production; and/or (2) that sequence and structural characteristics suppressing recombination in close proximity to the centromere may not have evolved at neo-centromeres. Our study provides insight into how recombination landscapes vary and evolve in mammals, and will provide a valuable resource for studies of evolution, genetic improvement, and population management in red deer and related species.
A Szentendrei-sziget zárt ártéri tölgyesei (Melico nutantis-Quercetum roboris KEVEY 2008)
Authors: Kevey Balázs , Bőhm Éva Irén 
Published: July 2017

Jelen tanulmány a Szentendrei-sziget zárt száraz tölgyeseinek társulási viszonyait mu­tatja be tíz cönológiai felvétel alapján. A felmért állományok az egyéb alföldi tájak erdei közül a Sziget­köz zárt ártéri tölgyeseivel (Melico nutantis-Quercetum roboris) mutatják a legközelebbi rokonságot. Az elemzési eredmények szerint ezen erdőkben az elmúlt 70 év alatt megnövekedett a természetes gyo­mok (W), a meghonosodott idegen fajok (I) és az agresszív tájidegen inváziós fajok (AC) aránya.
A Vaccinium microcarpum (Turcz. ex Rupr.) Schmalh. Magyarországon
Authors: Nagy János György , Zsinka Bernadett , Verebélyi Viktória , Zorkóczy Orsolya Krisztina , Tyler Teadora 
Published: July 2017

A növényt, amelyet 1994-ben Vaccinium oxycoccos L. néven közöltek a Siroki Nyírjes-tóról, e cikk első szerzője 1999-ben Vaccinium microcarpum (Turcz. ex Rupr.) Schmalh. fajként azonosította. A határozás helyességét bizonyító morfometriai tulajdonságok gyűjtésére 2016. augusztus 24-én került sor a siroki Nyírjes-tó tőzegmohalápján és szeptember 2-án és 3-án a beregi Báb-tava és a Nyíres-tó tőzegmohalápján. A vizsgálatokhoz felhasználtuk a Beregi-lápokon készített korábbi saját fényképfelvételeinket is. A siroki állomány növényeinek apró, háromszög-tojásdad alakú levelei a levélvállnál a legszélesebbek, a tojásdad-elliptikus murvák a csupasz virágkocsányok alsó harmadában fejlődnek, sötét rózsaszín virágaik magánosak, a porzószálak abaxiális felülete mindenütt szőrős, és a termés körte alakú. A beregi állomány növényeinek ezzel szemben elliptikus-tojásdad levelei szélességében és hosszúságában is jóval nagyobbak. Szőrös virágkocsányaik középső harmadában fejlődnek a szálas-lándzsás murvák, fehér virágaik (2)–3–4–(5) virágú virágzatot alkottak, a porzószálaknak csak a szélei szőrösek, a termés gömb alakú. A. A gyűjtött adatok statisztikai elemzése alátámasztotta, hogy a Sirokon található növények V. microcarpum fajhoz, míg a beregiek V. oxycoccos fajhoz tartoznak.
A Flow-Injection Method for the Determination of the Total Iron with 3,4-Dihydroxypenylacetic Acid using a Specially Home-Designed Injection System
Authors: Najib Fadhil 
Published: July 2017

A special injection system was designed in place of the ordinary commertial rotary injection valve usually used in flow-injection analysis (FIA). The system is a combination of two glass liquid distributing valves, a three-way and a four-way types. The two valves were connected together with PVC tubings of 1 mm. I.D. in such a way to produce an external loop having a volume of about 100 μL. The loop can be loaded with the desired solution without disturbing the flow in the rest of the manifold. The system was used successfully to determine total Iron in iron-containing drugs spectrophotometrically using 3,4-dihydroxyphenyl acetic acid (3,4- DHPAA) as reagent at 596nm. and a flow-rate of 0.05mL/min. The carrier rate of 1 mL/min. The calibration curve was linear between 0 - 8.3 ppm total Iron with a correlation coefficient r = 0.99996 confidence interval (y ± ts / √n) was 72.44 ± 0.6 at 95% confidence limit degree of freedom = 5.
Analysis of Iron containing drugs after dissolution with 0.005M HCl or HNO3 gave errors not exceeding 5% represented by recovery tests of standard Iron solutions added to these samples. At least 20 samples could be determined per hour with coefficient of variation between 1.1 - 1.4%.
A Flow-Injection Method for the Determination of the Total Iron using 3,4-Dihydroxybenzaldehyde
Authors: Najib Fadhil , Rafiq Arian 
Published: July 2017

A home-made design flow-injection system has been described in a previous work. This system has been applied in the present work for the determination of total iron using the reagent 3,4-dihydroxybenzaldehyde (3,4-DHBA). Optimization of all conditions were as follows: λmax 440 nm., pH of the carrier stream(C.S) 8.8 and its flow rate with the reagent 1.1 ml.min-1, reagent concentration 0.001M and the Manifold length was 60cm. Optimum, linear range of the calibration curve plotted by the method of Least Square with any one of the two equations Y=a+bX or Y=bX; including zero (the blank reading) as one of the standards, was between 0 - 8ppm. total Iron. The accuracy of the method was measured by calculating percentage recovery of 10 μg Iron (II+III) added to samples of Iron-Drugs after dissolution with 0.1 MHCl. The error did not exceed 5% with Coefficient of Variation between 2.5 - 3.3% Paired Comparison by t-test between two calibration curves showed no significant difference at 95% confidence limit.
Separation and Characterization of Polyoheniloxidase (PPO) from Melissia Officinalis
Authors: Sabir D. , Putros B. 
Published: July 2017

Polyphenol oxidase ( ppo) of Melissia officinalis was isolated and purified by gel
filtration and ion exchange chromatography. Three isoenzymes were separated.The
isoelectric points and some kinetic properties of these isonzymes are reported.
Synthesis of some oxopyrano-oxazine compounds from the reactions of malonyl with organonitriles
Authors: Hussain Faiq , Hawaiz Farouq 
Published: July 2017

The reaction of malonyl chloride with RCN (R: Cyclopentyl , CHPU2 , C6II3BTF)
at 100 C" and room temperature yielded pyrimidine derivatives , 2(R: Cyclopentyl )
and oxopyrano oxazine derivatives 4(R,cyclopentyl ; CHphz, Cd{jBrF) respectively ,
The structures of these products have been determined by elemental analysis and
spectroscopic methods
Extra Corporial Shock Wave Lithotripsy Sulaimani Teaching Hospital
Authors: Rasheed Aso 
Published: July 2017

A total of 70 patients with urinary stone disease had ESWL therapy in sulaimania teaching
hospital .Disigne; this is a prospective study on a recent available trestment
Clinical assessment were made by post ESWL therapy when the patients pass the gravels and followed by a series of radiological examinations for the success of the
therapy results; tie study showed a success rate of 77% patients required up to 3 months to achieve stone free .
Conclusion; ESWL provide a non invasive,simple
therapy for the management of urinary stone disease, provided the stone is less than 2cm.
Synthesis and Characterization of Novel Biological Mixed Organometallic Chromium (III) Complex of Potential Allyl-Sulfur Compounds of Garlic, Allicin
Authors: Andullah M. , Tofiq D. 
Published: July 2017

From the readily acid and base hydrolysis (pH - dependence) of loosely Cr - S bond of bis (L- cysteinato)chromium (III) complexes, a biological mixed organometallic
- werner chromium complex, of trans - bis [(n3) s - allyl mercapto cysteinato ] chromium (III) hydroxide, has been synthesized via intermolecular insertion reaction of allyl sulfenic acid, which was extracted and isolated from natural garlic. This complex was characterized using IR, NMR, UV -Visible spectroscopic techniques and elemental analysis. Also biological activity of the prepared cormplex was tested in vitro.
Visual Investigation of the Radial Energy Distribution of the Ions Produced by a Low Pressure Saddle Field Ion Source
Authors: Mahmood Aras 
Published: July 2017

A simple Practical method is used to investigate the distribution of the positive ion in the beam produced by a low pressure saddle field ion source according to their energies. It was found that the more energetic ions are those in the central portion of the ion beam wile the ion energy decreases radially toward the edges of the beam.
Ductility Ratio and Toughness Index of Reinforced Concrete Slabs Subjected to High Temperature
Authors: M. Ahmed , Qarani Omer 
Published: July 2017

Ductility ratio and toughness index were studied for two -way reinforced concrete slabs subjected to high temperature and cooling. . Empirical equations were developed to predict the ductility ratio and toughness index ( in terms of temperature and reinforced ratio) of such slabs under uniformly distributed load . These proposed equation gave good agreement when compared with the experimental results, with a correlation factor for ductility ratio and toughness index of 0.94 and 0.95 ,respectively.
Stress-Strain Curve of Fibrous Concrete in Compression
Authors: Aziz Omer , Abdul-Ahad Ramzi 
Published: July 2017

A simple experimental technique was used to obtain the stress-strain curves of the normal weight concrete containing steel fibers. An analytic expression for the stress-strain relationship of the normal weight fibrous concrete is developed. Equations to predict the ultimate strain and the block stress parameters of the fibrous concrete were developed to reflect experimental results. The analytic expression has four constants, which depend on the properties of both the ascending and descending portion of the stress-strain curve and can be evaluated from the knowledge of the four key points of the curve.
Cost Comparison and Performance of Different Types of Reinforcement for Two –Way Slabs
Authors: Muhamed Ahmed 
Published: July 2017

The effectiveness of the member should not take only from strength point of view, but also from other considerations. A cost analysis of two-way concrete slabs was studied. The variables were type of reinforcement (bars,fibers, and wire meshes),and cost of materials (including cost of labors). The results indicated that the variation of steel content and labor prices seems to have a significant contribution in the cost objective function. Cost of ferrocemnt slab panels is high relative to its performance, while fibrous slab panels have more ductility with less cost.
A Reconnaissance Gravity and Magnetic Study in Aqra Plain
Authors: Ghaib Fadhil , Abdul-Karim Salih , Mohammad Rashied 
Published: July 2017

A gravity and magnetic survey was carried out as a first study of this kind in Aqra plain area (NE of lraq). The survey occupied 116 gravity stations a long the main roads, as
well as some sub roads. In addition that 29 magnetic readings along the main road between Aqra town and Bardarash village where taken. The aim of this work is to obtain the main subsurface, shallow and deep structural units. The regional and residual anomalies for both gravity and magnetic data have been analysed qualitatively were related to the expected geological features. The study showed that the basement
rocks slope towards north and northeast with a depth of a bout 6-7km.
The Prevalence of Helicobacter Pylori in Upper Gastrointestinal Disorders
Authors: Baban Fuad , Mohammad Mohammad 
Published: July 2017

Background: Helicobacter pylori are a gram negative spiral bacilli that cause one of the most chronic infection through out the world. Helicobacter pylori infection is associated with many important and serious gastrointestinal diseases like peptic ulcer, chronic gastritis, a known precursor of gastric carcinoma.
Method: we studied the prevalence of helicobacter pylori infection in a group of patients who presented with various upper G.I discomfort between marches 1997-November 1999. 400 patients were enrolled , they were examined clinically and by upper G.1 endoscopy and 2 piece biopsy were taken from the antrum for rapid wease test for detection of helicobacter pylori infection
Results: Helicobacter pylori infection is a common infection and for any age group
the incidence of infection was more than 60% , pain was the most common presenting symptom (%93), patient harboring ulcer were 88% positive for urease ( 89% in DU, 86% in GU), 72% of patients with endoscopic findings other than ulcer were urease positive and 70% of patients with gastric carcinoma were positive while 64% of patients with negative endoscopy ( non ulcer dyspepsia) were urease positive.

Conclusion: infection with helicobacter pylori is common in this community and is strongly associated with an increase risk of peptic ulcer, gastritis and
gastric carcinoma however many dyspeptic patients with Helicobacter pylori infection have no endoscopic abnormality ( Functional, non ulcer dyspepsia)
we found that urease test is a rapid, cheap and practical test for the detection of Helicobacter pylori infection.