bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tunable Aryl Alkyl Ionic Liquids with Weakly Coordinating Tetrakis((1,1,1,3,3,3‐hexafluoropropan‐2‐yl)oxy)borate [B(hfip)4] Anions
Authors: Kaliner Maria , Rupp Alexander , Krossing Ingo , Strassner Thomas 
Published: June 2016

AbstractWeakly coordinating borate or aluminate anions have recently been shown to yield interesting properties of the resulting ionic liquids (ILs). The same is true for large phenyl‐substituted imidazolium cations, which can be tuned by the choice, position, or number of substituents on the aromatic ring. We were therefore interested to combine these aryl alkyl imidazolium cations with the weakly coordinating tetrakis((1,1,1,3,3,3‐hexafluoropropan‐2‐yl)oxy)borate [B(hfip)4]− anions to study the physical properties and viscosities of these ionic liquids. Despite the large size and high molecular weight of these readily available ILs, they are liquid at room temperature and show remarkably low glass transition points and relatively high decomposition temperatures.
Optimizing Optoelectronic Properties of Pyrimidine‐Based TADF Emitters by Changing the Substituent for Organic Light‐Emitting Diodes with External Quantum Efficiency Close to 25 % and Slow Efficiency Roll‐Off
Authors: Wu Kailong , Zhang Tao , Zhan Lisi , Zhong Cheng , Gong Shaolong , Jiang Nan , Lu Zheng‐Hong , Yang Chuluo 
Published: June 2016

AbstractA series of green butterfly‐shaped thermally activated delayed fluorescence (TADF) emitters, namely PXZPM, PXZMePM, and PXZPhPM, are developed by integrating an electron‐donor (D) phenoxazine unit and electron‐acceptor (A) 2‐substituted pyrimidine moiety into one molecule via a phenyl‐bridge π linkage to form a D–π–A–π–D configuration. Changing the substituent at pyrimidine unit in these emitters can finely tune their emissive characteristics, thermal properties, and energy gaps between the singlet and triplet states while maintaining frontier molecular orbital levels, and thereby optimizing their optoelectronic properties. Employing these TADF emitters results in a green fluorescent organic light‐emitting diode (OLED) that exhibits a peak forward‐viewing external quantum efficiency (EQE) close to 25 % and a slow efficiency roll‐off characteristic at high luminance.
Time to the initiation of adjuvant chemotherapy does not impact survival in patients with resected pancreatic cancer
Authors: Mirkin Katelin A. , Greenleaf Erin K. , Hollenbeak Christopher S. , Wong Joyce 
Published: June 2016

BACKGROUNDSurgical resection with adjuvant chemotherapy is the standard of care for patients with pancreatic cancer, but to the authors' knowledge, little is known regarding the temporal relationship between chemotherapy initiation and survival. The current study analyzed the impact of time to the initiation of adjuvant chemotherapy.METHODSThe National Cancer Data Base (2003‐2011) was retrospectively reviewed for patients with clinical American Joint Committee on Cancer stages I to III resected pancreatic carcinoma. Time to chemotherapy was stratified at the 12‐week postoperative time point. Univariate and multivariate analyses were performed.RESULTSThe current study included 6706 patients who underwent surgical resection alone, 3723 patients who initiated adjuvant chemotherapy at ≤12 weeks, and 669 patients who initiated adjuvant chemotherapy at >12 weeks. Patients who received chemotherapy at >12 weeks were older and had greater comorbidities. Those undergoing a Whipple resection or total pancreatectomy were more likely to initiate chemotherapy later compared with those patients undergoing a distal surgical resection. Adjuvant chemotherapy conferred a survival benefit over surgical resection alone (P<.0001). There was no overall survival benefit observed for patients receiving adjuvant chemotherapy at ≤12 weeks compared with at >12 weeks (P =.5301). When stratified by pathological stage of disease, there was no survival benefit noted for the earlier initiation of chemotherapy: stage I: P =.2783; stage II: P =.0708; and stage III: P =.0778. After controlling for patient, disease, and surgery characteristics, both patients who initiated adjuvant chemotherapy at ≤12 weeks and at >12 weeks were found to have a 35% lower odds of mortality versus those who underwent surgical resection alone (P<.0001 for both).CONCLUSIONSThe earlier initiation of adjuvant chemotherapy does not appear to significantly impact long‐term survival in patients with resected pancreatic cancer. Because adjuvant chemotherapy confers a survival benefit, delayed chemotherapy should be offered when appropriate. Cancer 2016;122:2979‐2987. © 2016 American Cancer Society.
Maximum number of discriminable colors in a region of uniform color space
Authors: Brill Michael H. 
Published: June 2016

AbstractContinuing a discussion by Kuehni, this note examines the problem of fitting as many as possible colors in a 1‐JND radius sphere such that each pair of colors is separated by at least 1 JND. Kuehni announced nine. A first estimate yields a maximum of 13, but this is too many because colors populating adjacent spheres will be too close to each other. Accordingly, I derive the maximum number,
, of discriminable colors per unit volume of color space, and then formally compute from this number packing density a number of colors inside the unit sphere. That estimate, nearly 6, will undoubtedly erode when discrete color points are chosen within the unit sphere. Kuehni's estimate of 9 is too high. © 2016 Wiley Periodicals, Inc. Col Res Appl, 2016
New findings on type 2 diabetes in first‐generation Chinese migrants settled in Italy: Chinese in Prato (CHIP) cross‐sectional survey
Authors: Modesti Pietro A. , Calabrese Maria , Malandrino Danilo , Colella Andrea , Galanti Giorgio , Zhao Dong 
Published: June 2016

AbstractBackgroundChinese people are one of the fastest growing immigrant populations in Europe, and their health has become a key issue to host nations. Although type 2 diabetes (T2DM) is a big burden among migrant populations, data on Chinese immigrants in Europe are limited.MethodsA cross‐sectional survey was performed in 2014, adopting principles of community‐based participatory research to investigate T2DM, diagnosed by the American Diabetes Association fasting criteria, in Chinese first‐generation migrants aged 16 to 59 years settled in Prato (Italy). Association with different factors was investigated using logistic regression.ResultsOf the 1608 participants, 177 had T2DM (11.0%), 119 being newly diagnosed (7.4%). Among subjects with diabetes, 58 (32.8%) were aware of the disease; among subjects with diabetes aware of their condition, 46 (79%) were treated with glucose lowering drugs. Age‐standardized (World Health Organization 2001 population) prevalence of T2DM was 9.6% (95% CI 9.1 to 10.2%), being 12.0% (95% CI 11.0 to 12.9%) in men, and 7.8% (95% CI 7.1 to 8.4%) in women. At adjusted logistic regression, diabetes was associated with hypertension, current smoking, adiposity indices (waist circumference, waist‐to‐hip ratio, waist‐to‐height ratio, and body mass index), and high triglycerides. T2DM, adiposity indices, and high triglycerides were not associated with duration of stay in Italy.ConclusionsThe high prevalence of T2DM among first‐generation Chinese immigrants in Europe stresses the need for specific health programs for T2DM early diagnosis, treatment, and prevention. There is an urgent need for policies to support this group because current policies will produce major social and economic costs. Copyright © 2016 John Wiley & Sons, Ltd.
Mismatch in microbial food webs: predators but not prey perform better in their local biotic and abiotic conditions
Authors: Parain Elodie C. , Gravel Dominique , Rohr Rudolf P. , Bersier Louis‐Félix , Gray Sarah M. 
Published: June 2016

AbstractUnderstanding how trophic levels respond to changes in abiotic and biotic conditions is key for predicting how food webs will react to environmental perturbations. Different trophic levels may respond disproportionately to change, with lower levels more likely to react faster, as they typically consist of smaller‐bodied species with higher reproductive rates. This response could cause a mismatch between trophic levels, in which predators and prey will respond differently to changing abiotic or biotic conditions. This mismatch between trophic levels could result in altered top‐down and bottom‐up control and changes in interaction strength. To determine the possibility of a mismatch, we conducted a reciprocal‐transplant experiment involvingSarracenia purpureafood webs consisting of bacterial communities as prey and a subset of six morphologically similar protozoans as predators. We used a factorial design with four temperatures, four bacteria and protozoan biogeographic origins, replicated four times. This design allowed us to determine how predator and prey dynamics were altered by abiotic (temperature) conditions and biotic (predators paired with prey from either their local or non‐local biogeographic origin) conditions. We found that prey reached higher densities in warmer temperature regardless of their temperature of origin. Conversely, predators achieved higher densities in the temperature condition and with the prey from their origin. These results confirm that predators perform better in abiotic and biotic conditions of their origin while their prey do not. This mismatch between trophic levels may be especially significant under climate change, potentially disrupting ecosystem functioning by disproportionately affecting top‐down and bottom‐up control.
Reproductive efficiency and shade avoidance plasticity under simulated competition
Authors: Fazlioglu Fatih , Al‐Namazi Ali , Bonser Stephen P. 
Published: June 2016

AbstractPlant strategy and life‐history theories make different predictions about reproductive efficiency under competition. While strategy theory suggests under intense competition iteroparous perennial plants delay reproduction and semelparous annuals reproduce quickly, life‐history theory predicts both annual and perennial plants increase resource allocation to reproduction under intense competition. We tested (1) how simulated competition influences reproductive efficiency and competitive ability (CA) of different plant life histories and growth forms; (2) whether life history or growth form is associated with CA; (3) whether shade avoidance plasticity is connected to reproductive efficiency under simulated competition. We examined plastic responses of 11 herbaceous species representing different life histories and growth forms to simulated competition (spectral shade). We found that both annual and perennial plants invested more to reproduction under simulated competition in accordance with life‐history theory predictions. There was no significant difference between competitive abilities of different life histories, but across growth forms, erect species expressed greater CA (in terms of leaf number) than other growth forms. We also found that shade avoidance plasticity can increase the reproductive efficiency by capitalizing on the early life resource acquisition and conversion of these resources into reproduction. Therefore, we suggest that a reassessment of the interpretation of shade avoidance plasticity is necessary by revealing its role in reproduction, not only in competition of plants.
Is the relationship between mast‐seeding and weather in oaks related to their life‐history or phylogeny?
Authors: Koenig Walter D. , Alejano Reyes , Carbonero Maria Dolores , Fernández‐Rebollo Pilar , Knops Johannes M. H. , Marañón Teodoro , Padilla‐Díaz Carmen M. , Pearse Ian S. , Pérez‐Ramos Ignacio M. , Vázquez‐Piqué Javier , Pesendorfer Mario B. 
Published: June 2016

AbstractAlthough the functional basis of variable and synchronous seed production (masting behavior) has been extensively investigated, only recently has attention been focused on the proximate mechanisms driving this phenomenon. We analyzed the relationship between weather and acorn production in 15 species of oaks (genus Quercus) from three geographic regions on two continents, with the goals of determining the extent to which similar sets of weather factors affect masting behavior across species and to explore the ecological basis for the similarities detected. Lag‐1 temporal autocorrelations were predominantly negative, supporting the hypothesis that stored resources play a role in masting behavior across this genus, and we were able to determine environmental variables correlating with acorn production in all but one of the species. Standard weather variables outperformed “differential‐cue” variables based on the difference between successive years in a majority of species, which is consistent with the hypothesis that weather is linked directly to the proximate mechanism driving seed production and that masting in these species is likely to be sensitive to climate change. Based on the correlations between weather variables and acorn production, cluster analysis failed to generate any obvious groups of species corresponding to phylogeny or life‐history. Discriminant function analyses, however, were able to identify the phylogenetic section to which the species belonged and, controlling for phylogeny, the length of time species required to mature acorns, whether they were evergreen or deciduous, and, to a lesser extent, the geographic region to which they are endemic. These results indicate that similar proximate mechanisms are driving acorn production in these species of oaks, that the environmental factors driving seed production in oaks are to some extent phylogenetically conserved, and that the shared mechanisms driving acorn production result in some degree of synchrony among coexisting species in a way that potentially enhances predator satiation, at least when they have acorns requiring the same length of time to mature.
Myelin oligodendrocyte glycoprotein induces incomplete tolerance of CD4+ T cells specific for both a myelin and a neuronal self‐antigen in mice
Authors: Lucca Liliana E. , Axisa Pierre‐Paul , Aloulou Meryem , Perals Corine , Ramadan Abdulraouf , Rufas Pierre , Kyewski Bruno , Derbinski Jens , Fazilleau Nicolas , Mars Lennart T. , Liblau Roland S. 
Published: June 2016

T‐cell polyspecificity, predicting that individual T cells recognize a continuum of related ligands, implies that multiple antigens can tolerize T cells specific for a given self‐antigen. We previously showed in C57BL/6 mice that part of the CD4+ T‐cell repertoire specific for myelin oligodendrocyte glycoprotein (MOG) 35–55 also recognizes the neuronal antigen neurofilament medium (NF‐M) 15–35. Such bi‐specific CD4+ T cells are frequent and produce inflammatory cytokines after stimulation. Since T cells recognizing two self‐antigens would be expected to be tolerized more efficiently, this finding prompted us to study how polyspecificity impacts tolerance. We found that similar to MOG, NF‐M is expressed in the thymus by medullary thymic epithelial cells, a tolerogenic population. Nevertheless, the frequency, phenotype, and capacity to transfer experimental autoimmune encephalomyelitis (EAE) of MOG35‐55‐reactive CD4+ T cells were increased in MOG‐deficient but not in NF‐M‐deficient mice. We found that presentation of NF‐M15‐35 by I‐Ab on dendritic cells is of short duration, suggesting unstable MHC class II binding. Consistently, introducing an MHC‐anchoring residue into NF‐M15‐35 (NF‐M15‐35T20Y) increased its immunogenicity, activating a repertoire able to induce EAE. Our results show that in C57BL/6 mice bi‐specific encephalitogenic T cells manage to escape tolerization due to inefficient exposure to two self‐antigens.
Leaders' achievement goals and their integrative management of creative ideas voiced by subordinates or superiors
Authors: Sijbom Roy B. L. , Janssen Onne , Van Yperen Nico W. 
Published: June 2016

AbstractThe purpose of this research was to examine the joint impact of leader achievement goals and hierarchical position of the voicer of creative ideas (subordinate vs. superior) on the extent to which leaders (intent to) integrate these voiced creative ideas with their own ideas (integrative idea management). In a scenario‐based survey (study 1; N = 189), in which we measured participants' achievement goals, we found that the relationship between leaders' performance goals and their intention to integrate voiced creative ideas is contingent on the hierarchical position of the idea voicer. Similarly, in an experimental study (study 2; N = 94), in which we experimentally induced achievement goals, we found that leaders display lower integrative intentions when ideas are voiced by a subordinate rather than a superior, but this was only true for leaders pursuing performance goals. Furthermore, the results of an additional, exploratory analysis suggest that the hierarchical position of the voicer of creative ideas had an indirect effect on integrative behavior through integrative intentions for performance goal leaders and no effect for mastery goal leaders. Together, these findings advance our understanding of how middle management leaders are influenced by their own achievement goals when managing the creative ideas voiced by subordinates and superiors.
Quality of service provision and capacity expansion through extended‐DSA for 5G
Authors: Herzog Uwe , Georgakopoulos Andreas , Belikaidis Ioannis‐Prodromos , Fitch Michael , Briggs Keith , Diaz Salvador , Carrasco Óscar , Moessner Klaus , Miscopein Benoit , Mumtaz Shahid , Demestichas Panagiotis 
Published: June 2016

Abstract5G systems are expected to advance on a number of aspects compared with current systems, for example, providing a 1000 times higher capacity, a much lower latency and improved quality of user experience. This paper presents the vision and approach followed by the H2020 project SPEED‐5G. The approach is based on densification of small cells, exploitation of Multi‐RAT, development of new resource management techniques and a more efficient use of spectrum. A novel 5G system architecture is proposed based on the Network Slicing paradigm, which enables a highly flexible, scalable and backwards compatible architecture. A core aspect is the definition of a new MAC layer that facilitates Multi‐RAT access and allows prioritising and allocating traffic across heterogeneous access technologies. Copyright © 2016 John Wiley & Sons, Ltd.
Effects of maturity stage and lactic acid bacteria on the fermentation quality and aerobic stability of Siberian wildrye silage
Authors: Li Ping , Bai Shiqie , You Minghong , Shen Yixin 
Published: June 2016

AbstractIt is difficult to make good quality of silage from alpine gramineous from the Qinghai Tibetan plateau. The effects of lactic acid bacteria (LAB) on the fermentation quality and aerobic stability of Siberian wildrye silage were studied in southeast of the Qinghai Tibetan plateau. Siberian wildrye materials were freshly cut at the sprouting stage, flowering stage, and milky stage. Silage was prepared by using a small‐scale silage fermentation system (bag silos). Lactobacillus plantarum (LP, 5 × 108 cfu/kg FM), Lactobacillus buchneri (LB, 5 × 108 cfu/kg FM) and their mixture (LP+LB, 5 × 108 cfu/kg FM) as silage additives were separately added to ensiled forages, and no additive served as control (CK). These bag silos were kept at room temperature (<15°C), and the silage qualities were analyzed after 60 days of ensiling. The number of indigenous LAB on fresh materials was less than that of yeasts and molds, and LAB species showed specification adapted to low temperature. LAB inoculated silages had lower (P < 0.05) pH value, NH3‐N/TN and butyric acid content compared with control silage. Silage treated with LB had higher contents of acetic acid, propionic acid, WSC and CP. However, the aerobic stability of silages inoculated with LAB did not differ significantly between stages (P > 0.05). When fermentation characteristics, chemical composition, and aerobic stability were considered, treatment with L. plantarum resulted in high quality of Siberian wildrye silage harvested at the flowering stage in the alpine region.
Anhedonia and individual differences in orbitofrontal cortex sulcogyral morphology
Authors: Zhang Hyden , Harris Lauren , Split Molly , Troiani Vanessa , Olson Ingrid R. 
Published: June 2016

AbstractThree types of orbitofrontal cortex (OFC) sulcogyral patterns that have been identified in the population, and the distribution of these three types in clinically diagnosed schizophrenic patients has been found to be distinct from the normal population. Schizophrenia is associated with increased levels of social and physical anhedonia. In this study, we asked whether variation in anhedonia in a neurologically normal population is associated with altered sulcogyral pattern frequency. OFC sulcogyral type was classified and anhedonia was measured in 58 normal young adults, and the relationship between OFC sulcogyral type and anhedonia was explored. In line with other studies conducted in chronic schizophrenia, individuals with higher levels of physical anhedonia demonstrated atypical sulcogyral patterns. Individuals with higher physical anhedonia showed a reduced incidence of Type I OFC and an increased incidence of Type II OFC in the left hemisphere compared to individuals with lower physical anhedonia. These findings support the notion that Type I OFC sulcogyral pattern is protective of anhedonia compared to Type II, even in individuals that are not schizophrenic. Overall, these results support the view that symptoms and neural indices typically associated with neuropsychiatric disorders actually reflect quantitative traits that are continuously distributed throughout the general population. Hum Brain Mapp 37:3873–3881, 2016. © 2016 Wiley Periodicals, Inc.
Longitudinal diffusion tensor imaging after pediatric traumatic brain injury: Impact of age at injury and time since injury on pathway integrity
Authors: Ewing‐Cobbs Linda , Johnson Chad Parker , Juranek Jenifer , DeMaster Dana , Prasad Mary , Duque Gerardo , Kramer Larry , Cox Charles S. , Swank Paul R. 
Published: June 2016

AbstractFollowing pediatric traumatic brain injury (TBI), longitudinal diffusion tensor imaging may characterize alterations in initial recovery and subsequent trajectory of white matter development. Our primary aim examined effects of age at injury and time since injury on pathway microstructure in children ages 6–15 scanned 3 and 24 months after TBI. Microstructural values generated using tract‐based spatial statistics extracted from core association, limbic, and projection pathways were analyzed using general linear mixed models. Relative to children with orthopedic injury, the TBI group had lower fractional anisotropy (FA) bilaterally in all seven pathways. In left‐hemisphere association pathways, school‐aged children with TBI had the lowest initial pathway integrity and showed the greatest increase in FA over time suggesting continued development despite incomplete recovery. Adolescents showed limited change in FA and radial diffusivity and had the greatest residual deficit suggesting relatively arrested development. Radial diffusivity was persistently elevated in the TBI group, implicating dysmyelination as a core contributor to chronic post‐traumatic neurodegenerative changes. The secondary aim compared FA values over time in the total sample, including participants contributing either one or two scans to the analysis, to the longitudinal cases contributing two scans. For each pathway, FA values and effect sizes were very similar and indicated extremely small differences in measurement of change over time in the total and longitudinal samples. Statistical approaches incorporating missing data may reliably estimate the effects of TBI and provide increased power to identify whether pathways show neurodegeneration, arrested development, or continued growth following pediatric TBI. Hum Brain Mapp 37:3929–3945, 2016. © 2016 Wiley Periodicals, Inc.