bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ice cream supplemented with grape juice residue as a source of antioxidants
Authors: Vital Ana Carolina Pelaes , Santos Nadine Woruby , Matumoto‐Pintro Paula Toshimi , da Silva Scapim Monica Regina , Madrona Grasiele Scaramal 
Published: May 2017

Grape juice residue was incorporated into ice cream at 2.5%, 5.0% and 10.0% to obtain a product with functional characteristics. The chemical composition, colour, total phenolic compounds, antioxidant capacity and sensory acceptance of the ice creams were analysed at day 0 and after 40 days of storage. Ice creams containing grape juice residue had a higher concentration of phenolic compounds and antioxidant activity compared to the control samples. Consumers’ acceptance was similar for all products. At the end of storage, the polyphenol content and antioxidant activity had decreased. Grape juice residue has potential as a natural source of antioxidants to develop new products.
Patient Experience of Chronic Illness Care and Medical Home Transformation in Safety Net Clinics
Authors: Tung Elizabeth L. , Gao Yue , Peek Monica E. , Nocon Robert S. , Gunter Kathryn E. , Lee Sang Mee , Chin Marshall H. 
Published: May 2017

ObjectiveTo examine the relationship between medical home transformation and patient experience of chronic illness care.Study SettingThirteen safety net clinics located in five states enrolled in the Safety Net Medical Home Initiative.Study DesignRepeated cross‐sectional surveys of randomly selected adult patients were completed at baseline (n = 303) and postintervention (n = 271).Data Collection MethodsQuestions from the Patient Assessment of Chronic Illness Care (PACIC) (100‐point scale) were used to capture patient experience of chronic illness care. Generalized estimating equation methods were used to (i) estimate how differential improvement in patient‐centered medical home (PCMH) capability affected differences in modified PACIC scores between baseline and postintervention, and (ii) to examine cross‐sectional associations between PCMH capability and modified PACIC scores for patients at completion of the intervention.Principal FindingsIn adjusted analyses, high PCMH improvement (above median) was only marginally associated with a larger increase in total modified PACIC score (adjusted β = 7.7, 95 percent confidence interval [CI]: −1.1 to 16.5). At completion of the intervention, a 10‐point higher PCMH capability score was associated with an 8.9‐point higher total modified PACIC score (95 percent CI: 3.1–14.7) and higher scores in four of five subdomains (patient activation, delivery system design, contextual care, and follow‐up/coordination).ConclusionsWe report that sustained, 5‐year medical home transformation may be associated with modest improvement in patient experience of chronic illness care for vulnerable populations in safety net clinics.
End‐of‐Life Care Planning in Accountable Care Organizations: Associations with Organizational Characteristics and Capabilities
Authors: Ahluwalia Sangeeta C. , Harris Benjamin J. , Lewis Valerie A. , Colla Carrie H. 
Published: May 2017

ObjectiveTo measure the extent to which accountable care organizations (ACOs) have adopted end‐of‐life (EOL) care planning processes and characterize thoseACOs that have established processes related toEOL.Data SourcesThis study uses data from three waves (2012–2015) of the National Survey ofACOs. Respondents were 397ACOs participating in Medicare, Medicaid, and commercialACOcontracts.Study DesignThis is a cross‐sectional survey study using multivariate ordered logit regression models. We measured the extent to which theACOhad adoptedEOLcare planning processes as well as organizational characteristics, including care management, utilization management, health informatics, and shared decision‐making capabilities, palliative care, and patient‐centered medical home experience.Principal FindingsTwenty‐one percent ofACOs had few or noEOLcare planning processes, 60 percent had some processes, and 19.6 percent had advanced processes.ACOs with a hospital in their system (OR: 3.07;p = .01), andACOs with advanced care management (OR: 1.43;p = .02), utilization management (OR: 1.58,p = .00), and shared decision‐making capabilities (OR: 16.3,p = .000) were more likely to haveEOLcare planning processes than those with no hospital or few to no capabilities.ConclusionsThere remains considerable room for today'sACOs to increase uptake ofEOLcare planning, possibly by leveraging existing care management, utilization management, and shared decision‐making processes.
Characterizing the Extent of Spatially Integrated Floodplain and Wetland Systems in the White River, Indiana, USA
Authors: Lane C. R. , Hall A. , D'Amico E. , Sangwan N. , Merwade V. 
Published: May 2017

AbstractFloodplain delineation may inform protection of wetland systems under local, state, or federal laws. Nationally available Federal Emergency Management Agency Flood Insurance Rate Maps (FIRMs, “100‐year floodplain” maps) focus on urban areas and higher‐order river systems, limiting utility at large scales. Few other national‐scale floodplain data are available. We acquired FIRMs for a large watershed and compared FIRMs to floodplain and integrated wetland area mapping methods based on (1) geospatial distance, (2) geomorphic setting, and (3) soil characteristics. We used observed flooding events (OFEs) with recurrence intervals of 25‐50 to >100 years to assess floodplain estimate accuracy. FIRMs accurately reflected floodplain areas based on OFEs and covered 32% of river length, whereas soil‐based mapping was not as accurate as FIRMs but characterized floodplain areas over approximately 65% of stream length. Geomorphic approaches included more areas than indicated by OFE, whereas geospatial approaches tended to cover less area. Overall, soil‐based methods have the highest utility in determining floodplains and their integrated wetland areas at large scales due to the use of nationally available data and flexibility for regional application. These findings will improve floodplain and integrated wetland system extent assessment for better management at local, state, and national scales.
Relating Product Prices to Long‐Run Marginal Cost: Evidence from Solar Photovoltaic Modules
Authors: Reichelstein Stefan , Sahoo Anshuman 
Published: May 2017

AbstractA basic tenet of microeconomics is that for a competitive industry in equilibrium the market price of a product will be equal to its marginal cost. This paper develops a model framework and a corresponding empirical inference procedure for estimating long‐run marginal cost in industries where production costs decline over time. In the context of the solar photovoltaic (PV) module industry, we rely primarily on firm‐level financial accounting data to estimate the long‐run marginal cost of PV modules for the years 2008–2013. During those years, the industry experienced both unprecedented price declines and significant expansions of manufacturing capacity. We compare the trajectory of average sales prices with the estimated long‐run marginal costs in order to quantify the extent to which actual price declines were attributable to reductions in production costs. The trajectory of estimated product costs is then extrapolated to forecast an equilibrium trend line for future PV module prices.
Transcription factors CEP‐1/p53 and CEH‐23 collaborate with AAK‐2/AMPK to modulate longevity in Caenorhabditis elegans.
Authors: Chang Hsin‐Wen , Pisano Steve , Chaturbedi Amaresh , Chen Jennifer , Gordon Sarah , Baruah Aiswarya , Lee Siu Sylvia 
Published: May 2017

SummaryA decline in mitochondrial electron transport chain (ETC) function has long been implicated in aging and various diseases. Recently, moderate mitochondrial ETC dysfunction has been found to prolong lifespan in diverse organisms, suggesting a conserved and complex role of mitochondria in longevity determination. Several nuclear transcription factors have been demonstrated to mediate the lifespan extension effect associated with partial impairment of the ETC, suggesting that compensatory transcriptional response to be crucial. In this study, we showed that the transcription factors CEP‐1/p53 and CEH‐23 act through a similar mechanism to modulate longevity in response to defective ETC in Caenorhabditis elegans. Genomewide gene expression profiling comparison revealed a new link between these two transcription factors and AAK‐2/AMP kinase (AMPK) signaling. Further functional analyses suggested that CEP‐1/p53 and CEH‐23 act downstream of AAK‐2/AMPK signaling and CRTC‐1 transcriptional coactivator to promote stress resistance and lifespan. As AAK‐2, CEP‐1, and CEH‐23 are all highly conserved, our findings likely provide important insights for understanding the organismal adaptive response to mitochondrial dysfunction in diverse organisms and will be relevant to aging and pathologies with a mitochondrial etiology in human.
Characterization of Self‐Defining Memories in Individuals with Severe Alcohol Use Disorders After Mid‐Term Abstinence: The Impact of the Emotional Valence of Memories
Authors: Nandrino Jean‐Louis , Gandolphe Marie‐Charlotte 
Published: May 2017

BackgroundSelf‐defining memories (SDM) are distinguished from other autobiographical memory (AM) processes to delineate those associated with the sense of personal identity and continuity in one's individual history. With chronic alcohol consumption, the construction of such memories may be modified in terms of specificity, valence, meaning‐making, and evoked topics. This study sought to characterize SDM in a population of 27 patients with alcohol use disorder (AUD) who had been abstinent for at least 2 months compared with 28 control participants.MethodsBesides cognitive and clinical assessment, participants were told to describe verbally and date 5 SDM and their narratives were recorded. For each memory, 5 dimensions were evaluated: level of specificity, emotional valence, integration of meaning, topics, and distance of memory in time.ResultsOverall, SDM of participants with AUD were specifically characterized by (i) low specificity, (ii) low integration, (iii) a predominance of memories with negative emotional valence and a low frequency of positive memories, and (iv) a low frequency of topics related to success. When different dimensions of the SDM were crossed, their characteristics depended mainly on the valence of the memory. Negative memories were more frequent, more specific and more integrated, while positive SDM were less frequent, less specific and less integrated.ConclusionsThe results underline the construction of a form of SDM with drinking problems that is mainly characterized by the disruption of positive memory and the presence of highly specific and integrated negative experiences. A disruption of the integration process modulated by the valence of memories could have repercussions on maintaining a sense of personal identity, the pursuit of personal goals and on social adaptability, and could constitute one of the main risks associated with persistent drinking problems. These results highlight the relevance of developing AM training programs for patients with AUD.
Optical coherence tomography angiography of the macular microvasculature changes in retinitis pigmentosa
Authors: Koyanagi Yoshito , Murakami Yusuke , Funatsu Jun , Akiyama Masato , Nakatake Shunji , Fujiwara Kohta , Tachibana Takashi , Nakao Shintaro , Hisatomi Toshio , Yoshida Shigeo , Ishibashi Tatsuro , Sonoda Koh‐Hei , Ikeda Yasuhiro 
Published: May 2017

AbstractPurposeTo investigate the macular microvasculature changes by optical coherence tomography angiography (OCTA) and analyse the correlation between these changes and central visual function in patients with retinitis pigmentosa (RP).MethodsWe measured the area of the foveal avascular zone (FAZ) and the foveal and parafoveal flow density (FFD and PFD, respectively) in the superficial (S) and deep (D) retinal plexus by OCTA (AngioVue) and compared these values between 73 RP patients and 36 healthy controls. We analysed the relationships between these microvasculature measurements and central visual functions such as visual acuity (VA) and the values of static perimetry tests (Humphrey Field Analyzer, the central 10–2 program) in the RP patients.ResultsThe FFD‐S, PFD‐S and PFD‐D were significantly decreased in the RP patients compared to the controls (all p < 0.05), whereas there was no significant difference in the FAZ‐S, FAZ‐D or FFD‐D (all p > 0.05). A subgroup analysis showed that the RP patients with VA <20/20 had increased FAZ‐S compared to the controls and RP patients with VA ≥20/20 (p = 0.01 and p = 0.007, respectively). Spearman rank testing demonstrated that PFD‐S and PFD‐D were significantly correlated with all of the central visual parameters (all p < 0.01). The FAZ‐S and FFD‐S were significantly correlated with VA, and FAZ‐D and FFD‐D showed no significant correlation.ConclusionBoth the superficial and deep layers of the parafoveal microvasculature are attenuated in RP and correlated with reduced central visual function. The foveal microvasculature, especially in the deep layer, was relatively preserved until mild‐to‐moderately advanced stages.
Pharmacokinetics of Transdermal Etofenamate and Diclofenac in Healthy Volunteers
Authors: Drago Sara , Imboden Roger , Schlatter Philipp , Buylaert Mirabel , Krähenbühl Stephan , Drewe Juergen 
Published: May 2017

AbstractLittle is known about the course of the plasma concentration and the bioavailability of non‐steroidal anti‐inflammatory drugs (NSAIDs) contained in dermal patches. We compared an etofenamate prototype patch (patent EP 1833471) and a commercially available diclofenac epolamine patch regarding the bioavailability of the active ingredients relative to respective i.m. applications and regarding their plasma concentration–time course. Twenty‐four healthy human volunteers were treated using a parallel group design (n = 12 per group) with a single dermal patch (removed after 12 hr) followed (after a latency of 48 hr) by eight consecutive dermal patches every 12 hr to reach steady‐state conditions. The patches were generally well tolerated, but one volunteer treated with etofenamate developed an allergic contact dermatitis. After the first patch, Cmax was 0.81 ± 0.11 (mean ± S.E.M.) ng/mL (reached 12 hr after patch removal) for diclofenac and 31.3 ± 3.8 ng/mL for flufenamic acid (reached at patch removal), the main metabolite of etofenamate. Etofenamate was not detectable. After repetitive dosing, trough plasma concentrations after the eighth dose were 1.72 ± 0.32 ng/mL for diclofenac and 48.7 ± 6.6 ng/mL for flufenamic acid. Bioavailabilities (single dose) relative to i.m. applications were 0.22 ± 0.04% for diclofenac and 1.15 ± 0.06% for flufenamic acid. In conclusion, the relative bioavailability (compared to the respective i.m. application) of both drugs is low. The maximal plasma concentrations after topical administration of these drugs are well below the IC50 values for COX‐1 and COX‐2, explaining the absence of dose‐dependent toxicities.
Cannabinoid CB1/CB2 receptor agonists attenuate hyperactivity and body weight loss in a rat model of activity‐based anorexia
Authors: Scherma Maria , Satta Valentina , Collu Roberto , Boi Maria Francesca , Usai Paolo , Fratta Walter , Fadda Paola 
Published: May 2017

Background and PurposeAnorexia nervosa (AN) is a serious psychiatric condition characterized by excessive body weight loss and disturbed perceptions of body shape and size, often associated with excessive physical activity. There is currently no effective drug‐related therapy of this disease and this leads to high relapse rate. Clinical data suggest that a promising therapy to treat and reduce reoccurrence of AN may be based on the use of drugs that target the endocannabinoid (EC) system, which appears dysregulated in AN patients.Experimental ApproachThe activity‐based anorexia (ABA) rodent model mimics the severe body weight loss and increased physical activity, as well as the neuroendocrine disturbances (i.e. hypoleptinaemia and hypercortisolaemia) in AN. This study investigated whether cannabinoid agonists can effectively modify anorexic‐like behaviours and neuroendocrine changes in rats subjected to a repeated ABA regime that mimics the human condition in which patients repeatedly undergo a recovery and illness cycle.Key ResultsOur data show that subchronic treatment with both the natural CB1/CB2 receptor agonist Δ9‐tetrahydrocannabinol and the synthetic CB1/CB2 receptor agonist CP‐55,940 significantly reduced body weight loss and running wheel activity in ABA rats. These behavioural effects were accompanied by an increase in leptin signalling and a decrease in plasma levels of corticosterone.Conclusion and ImplicationsTaken together, our results further demonstrate the involvement of the EC system in AN pathophysiology and that strategies which modulate EC signalling are useful to treat this disorder, specifically in patients where physical hyperactivity plays a central role in its progression and maintenance.
Platelet distribution width as the prognostic marker in coronary bifurcation treatment
Authors: Kern Adam , Gil Robert J. , Bojko Krystian , Sienkiewicz Ewa , Januszko‐Giergielewicz Beata , Górny Jerzy , Bil Jacek 
Published: May 2017

AbstractBackgroundMean platelet volume (MPV) was proved to be a reliable prognostic factor in cardiac patients. However, platelet distribution width (PDW) was disclosed to be more specific marker of platelet reactivity. The aim of study was to evaluate whether baseline PDW value can predict the outcome in patients undergoing percutaneous coronary interventions (PCI) with drug‐eluting stent implantation within coronary bifurcation lesions.Materials and methodsIt was a two‐centre observational study, which included patients who underwent PCI within bifurcation lesions between January 2014 and December 2014. Thrombocytopenia below 100 000/μL and STEMI were the exclusion criteria. Analysed data came entirely from in‐hospital records and information obtained from the 12‐month telephone follow‐up.ResultsWe included 269 patients. Mean PDW value was 13·4 ± 2·5 fL, whereas median was 13 (Q1 < 11·6 fL, Q2 11·6–13 fL, Q3 13–14·8 fL and Q4 > 14·8 fL). We found strong correlation between PDW and MPV (r = 0·96, P < 0·001), but no correlation was revealed between red blood cell distribution width (RDW) and PDW (r = 0·003, P = 0·95) as well as RDW and MPV (r = 0·0018, P = 0·98). Receiver operating characteristics (ROC) curve showed that PDW for cutoff 15·8% can predict MACE rate with sensitivity of 79% and specificity of 47% (area under curve – AUC 0·654; P = 0·01). A ROC curve for PDW categorized by 1‐year TLR rate was described by optimal cutoff 16·3%, with sensitivity 69% and specificity 54% (AUC 0·697; P = 0·0015).ConclusionsPDW is an affordable and reliable predictor of 1‐year MACE and TLR rate after PCI within coronary bifurcation lesions.
Mass rearing and sterile insect releases for the control of Anastrepha spp. pests in Mexico – a review
Authors: Orozco‐Dávila Dina , Quintero Luis , Hernández Emilio , Solís Eduardo , Artiaga Trinidad , Hernández Refugio , Ortega Carlos , Montoya Pablo 
Published: May 2017

AbstractThe sterile insect technique (SIT) requires the rearing, sterilization, and release of large numbers of insects to induce sterility within wild pest populations. In 1992, the Mexican government launched a national campaign against economically important fruit fly pests, with the aim of establishing free areas and strengthening fruit exports. To achieve these objectives, the Moscafrut facility began operations in 1993 with the mass rearing of Anastrepha ludens (Loew) (Diptera: Tephritidae: Toxotrypanini) and in 2002 with Anastrepha obliqua (McQuart). Field releases of sterile insects began in the north of the country, and currently 51% of the country is free of these pests. In this review, we describe the mass‐rearing process and the quality control tests used in the production of the above‐mentioned species. As a case study, we also describe the achievements of applying the SIT against A. ludens populations in the citrus‐growing zone of the state of San Luis Potosí, which has resulted in dramatic reductions in both wild fly populations and the use of chemical sprays. We discuss the implications, achievements, and perspectives regarding the use of this technology to control Anastrepha pests in Mexico.
Inoculation of susceptible and resistant potato plants with the late blight pathogenPhytophthora infestans: effects on an aphid and its parasitoid
Authors: Lazebnik Jenny , Tibboel Marianne , Dicke Marcel , van Loon Joop J.A. 
Published: May 2017

AbstractPlants are exposed to microbial pathogens as well as herbivorous insects and their natural enemies. Here, we examined the effects of inoculation of potato plants,Solanum tuberosumL. (Solanaceae), with the late blight pathogenPhytophthora infestans(Mont.) de Bary (Peronosporales:Pythiaceae) on an aphid species commonly infesting potato crops and one of the aphid's major parasitoids. We observed the peach‐potato aphid,Myzus persicaeSulzer (Hemiptera:Aphididae), and its natural enemy, the biocontrol agentAphidius colemaniViereck (Hymenoptera:Braconidae), on potato either inoculated with water orP. infestans. Population growth of the aphid, parasitism rate of its natural enemy, and other insect life‐history traits were compared on several potato genotypes, the susceptible cultivar Désirée and genetically modified (GM) isogenic lines carrying genes conferring resistance toP. infestans. Effects ofP. infestansinoculation on the intrinsic rate of aphid population increase and the performance of the parasitoid were only found on the susceptible cultivar. Insect traits were similar when comparing inoculated with non‐inoculated resistantGMgenotypes. We also tested howGM‐plant characteristics such as location of gene insertion and number of R genes could influence non‐target insects by comparing insect performance amongGMevents. Different transformation events leading to different positions of R‐gene insertion in the genome influenced aphids either with or withoutP. infestansinfection, whereas effects of position of R‐gene insertion on the parasitoidA. colemaniwere evident only in the presence of inoculation withP. infestans. We conclude that it is important to study different transformation events before continuing with further stages of risk assessment of thisGMcrop. This provides important information on the effects of plant resistance to a phytopathogen on non‐target insects at various trophic levels.