bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical value of macrogenome next-generation sequencing on infections
Authors: Han Benfa , Zhang Xiaoli , Li Xiuxi , Chen Mei , Ma Yanlin , Zhang Yunxia , Huo Song 
Published: September 2024

Abstract
Intracranial infection (ICI) is a frequent and serious complication after neurosurgery. Macrogenome next-generation sequencing (mNGS) technology can provide reference for clinical diagnosis and treatment of ICI. This work aimed to explore the application value of mNGS technology in analyzing the clinical characteristics of human immunodeficiency virus (HIV) infection and ICI after neurosurgery. A total of 60 patients with ICI were enrolled as the research objects, all patients underwent routine cerebrospinal fluid analysis and traditional pathogen detection, followed by mNGS genome analysis. Using clinical diagnosis of ICI as the gold standard, the sensitivity, specificity, positive predictive value, and negative predictive value for both detection methods were calculated. Receiver operating characteristic curves were constructed to assess the area under the curve (AUC) for evaluating the clinical value of mNGS in suspected intracranial infectious pathogen diagnosis. Results showed a positivity rate of 71.67% (43 cases) with mNGS compared to 28.33% (17 cases) with traditional pathogen detection methods, demonstrating a significant difference (P < 0.05). The sensitivity of mNGS for detecting ICIs was 83.7%, significantly higher than the 34.88% observed with traditional methods (P < 0.05). The pathogen detection rate of mNGS was higher than traditional methods (P = 0.002), with an AUC of 0.856 (95% CI: 0.638–0.967), significantly greater than the AUC of 0.572 (95% CI: 0.350–0.792) for traditional methods (P < 0.05). mNGS successfully identified microorganisms such as Cryptococcus, Propionibacterium, Staphylococcus, Corynebacterium, Micrococcus, and Candida associated with ICIs. These findings underscore the clinical applicability of mNGS technology in analyzing the characteristics of HIV infection and ICI post-neurosurgical procedures. This technology enables more accurate diagnosis and treatment of ICIs, providing valuable insights for developing effective therapeutic strategies.
Exploring the hepatoprotective properties of citronellol: In vitro and in silico studies on ethanol-induced damage in HepG2 cells
Authors: Malik Muhammad Nasir Hayat , Abid Iqra , Ismail Sana , Anjum Irfan , Qadir Halima , Maqbool Tahir , Najam Komal , Ibenmoussa Samir , Bourhia Mohammed , Salamatullah Ahmad Mohammad , Wondmie Gezahign Fentahun 
Published: September 2024

Abstract
Citronellol (CT) is a monoterpene alcohol present in the essential oil of plants of the genus Cymbopogon and exhibits diverse pharmacological activities. The aim of the current study was to investigate the hepatoprotective potential of CT against ethanol-induced toxicity in HepG2 cell lines. Silymarin (SIL) was used as a standard drug. MTT, crystal violet assay, DAPI, and PI staining were carried out to assess the effect of ethanol and CT on cell viability. RT-PCR determined the molecular mechanisms of hepatoprotective action of CT. CT ameliorated cell viability and restricted ethanol-induced cell death. DAPI and PI staining showed distinct differences in cell number and morphology. Less cell viability was observed in the diseased group obviously from strong PI staining when compared to the CT- and SIL-treated group. Moreover, CT showed downregulation of interleukin (IL-6), transforming growth factor-beta 1 (TGF-β1), collagen type 1 A 1 (COL1A1), matrix metalloproteinase-1 (MMP-1), tissue inhibitor of metalloproteinase-1 (TIMP-1) and glutathione peroxidase-7 (GPX-7) levels. Molecular docking studies supported the biochemical findings. It is concluded that the cytoprotective activity of CT against ethanol-induced toxicity might be explained by its anti-inflammatory, immunomodulatory, and collagen-regulating effects.
(Re)Imagining the future of multicultural education: reinvesting, reorienting, and reshaping multicultural education
Authors: Young Jemimah L. , James Marlon , Williams John , Díaz Beltrán Ana Carolina , Neshyba Mónica V. 
Published: September 2024

Abstract
Multicultural education (ME) remains essential to the development of a critical mass of culturally and socially conscious global citizens. Yet, as a field, the minoritization of ME parallels the marginalization of those whom the field was designed to support and uplift. Despite growing movements to overturn policies and programs that support diverse learners, many still ponder whether ME remains relevant to American society. Thus, this article aimed to (re)imagine the future of ME by proffering three considerations to support the uptake and sustainability of ME. In the present article, we argue that scholars reinvest, reorient, and reshape ME. First, we argue that it is important to recognize that multicultural education (ME) is a unique field with a critical role in education as well as significant implications beyond the academic environment. Then, we must reinvest in the future of ME financially, socially, and emotionally. Through reinvestment, we can reorient the ME field, resituating it in relation to the challenges of today’s racially and ethnically tense, pluralistic society. To this end, reshaping ME programs is key, including revitalizing coursework to effectively prepare educators, lay persons, social justice advocates, and others interested in universal equity. Implications for the future of ME are provided, as well as recommendations for actualizing these considerations.
D-features or ellipsis in null subject licensing? Evidence from Brazilian and European Portuguese
Authors: Martins Ana Maria , Nunes Jairo 
Published: September 2024

Abstract
Holmberg (Holmberg, Anders. 2005. Is there a little pro? Evidence from Finnish. Linguistic Inquiry 36(4). 533–564) and its revised version in Holmberg et al. (Holmberg, Anders, Aarti Nayudu & Michelle Sheehan. 2009. Three partial null-subject languages: A comparison of Brazilian Portuguese, Finnish, and Marathi. Studia Linguistica 63(1). 59–97) derive the availability of null subjects in a given language from the interaction between T with/without a D(efiniteness)-feature and the features of subject pronouns. Their theory predicts the existence of consistent null subject languages, whose T has the D-feature, and partial null subject languages, whose T lacks the D-feature. This paper examines this D-feature approach to null subjects against the empirical evidence provided by Brazilian Portuguese, a partial null subject language, and European Portuguese, a consistent null subject language, showing that it cannot account for the range of microvariation observed with respect to different null subject pronouns and the type of T (finite vs. participle vs. gerund). We argue that, in comparison, the ellipsis account of null subject licensing put forward in Martins and Nunes (Martins, Ana Maria & Jairo Nunes. 2021. Brazilian and European Portuguese and Holmberg’s 2005 typology of null subject languages. In Sergio Baauw, Frank Drijkoningen & Luisa Meroni (eds.), Romance languages and linguistic theory 2018. Selected papers from “Going Romance” 32, Utrecht, 171–190. Amsterdam & Philadelphia: John Benjamins) fares better. It retains from Holmberg (Holmberg, Anders. 2005. Is there a little pro? Evidence from Finnish. Linguistic Inquiry 36(4). 533–564 et seq.) the insight that the licensing of null subjects depends on the interaction between the features of T and the features of subject pronouns but resorts only to ϕ-features and Case. Crucially, it relies on the (theoretically and empirically) plausible assumption that the relation between abstract ϕ-features and verbal agreement morphology need not be transparent.
Kommunale Gesundheitskampagnen in Zeiten des Klimawandels: Möglichkeiten und Grenzen kollektiver Sensibilisierung und Aktivierung
Authors: Scherenberg Viviane 
Published: September 2024

Zusammenfassung
Die enorme Bedeutung von Gesundheitskampagnen wurde besonders während der COVID-19-Pandemie deutlich. Doch auch angesichts der direkten und indirekten Folgen des Klimawandels scheint es erforderlich, effektive Gesundheitskampagnen zu entwickeln, um die Gesundheitsrisiken zu minimieren. Neben der gezielten Stärkung der umweltbezogenen Gesundheitskompetenz können gerade Gesundheitskampagnen einen bedeutenden Beitrag leisten, um die breite Bevölkerung zu sensibilisieren und zu aktivieren.
Evaluation einer Förderung für kommunale Steuerungsstrukturen für Gesundheitsförderung
Authors: Vollmer Janko , Stengel Verena , Loss Julika , Kolip Petra 
Published: September 2024

Zusammenfassung
Das GKV-Bündnis für Gesundheit fördert gesundheitsfördernde Steuerungsstrukturen in 63 Kommunen. Die wissenschaftliche Programmevaluation führte Online-Befragungen und Interviews mit den kommunalen Ansprechpersonen durch. Die Zwischenergebnisse zeigen, dass nach zwei Jahren Förderung die meisten Kommunen ein intersektorales Steuerungsgremium haben, in dem vielfältige Akteursgruppen vertreten sind. Verbesserungen sind vor allem noch bezüglich der Beteiligung bestimmter Ressorts und bei der Etablierung der Prozesskoordination in einigen Kommunen möglich.
Gemeinsam soziale Teilhabe und Gesundheit stärken: Programm teamw()rk
Authors: Bojkowska Izabela , Weiß Angelina , Salman Kristina , Reichert Cornelia 
Published: September 2024

Zusammenfassung
Das bundesweite Programm „teamw()rk“ stärkt Gesundheit und soziale Teilhabe von Menschen in Erwerbslosigkeit durch die Verzahnung von Arbeits- und Gesundheitsförderung. In Hessen und Berlin entwickeln Jobcenter und lokale Akteur*innen bedarfsgerechte, interdisziplinär umgesetzte Angebote. Praxiserfahrungen unterstreichen die Notwendigkeit von Partizipation und Empowerment. Weiterführende partizipative Forschung und politische Unterstützung sind entscheidend für eine nachhaltige Umsetzung.
Zunehmende Hitzetage erfordern bessere Zugänge zu Trinkwasser
Authors: Fischer Julian , Lanzl Dominik , Pinz Anika 
Published: September 2024

Zusammenfassung
Angesichts von Klimawandel und zunehmenden Hitzetagen wird es für Städte und Gemeinden immer wichtiger, die Zugänge zu Trinkwasser zu verbessern. Der gemeinnützige Verein a tip: tap zeigt in der Praxis erprobte Maßnahmen zur Förderung des Trinkwassergenusses auf.
Strategien für eine bewegungsfreundliche Kommune – Von der Planung bis zur Evaluation
Authors: Bußkamp Annalena , Vonstein Claudia , De Bock Freia , Bosle Catherin , Halbach Sarah , Aluttis Christoph 
Published: September 2024

Zusammenfassung
Bewegung ist ein Schlüsselfaktor für den Erhalt und die Förderung der Gesundheit. Kommunen nehmen eine entscheidende Rolle ein, da sie das Umfeld für alle Bürgerinnen und Bürger bewegungsfreundlich gestalten können. Hierzu können Kommunen sich an einem Prozess zur Entwicklung einer bewegungs- und gesundheitsförderlichen Lebenswelt der WHO orientieren, der im Programm „Älter werden in Balance“ getestet und im Rahmen des digitalen Planungstools „Impulsgeber Bewegungsförderung“ implementiert wurde.
New data about the provenance of the Early Eneolithic copper artefacts from western Lesser Poland
Authors: Wilk Stanisław , Zofia Anna Stos-Gale , Schwab Roland , Zastawny Albert , Sych Dawid , Kiełtyka-Sołtysiak Gabriela , Momot Małgorzata 
Published: September 2024

Abstract
The Early Eneolithic period in Lesser Poland is represented by the Lublin-Volhynian culture and the Wyciąże-Złotniki group. For both of them, the main cultural references were the Middle Copper Age groups from the Carpathian Basin (the Bodrogkeresztúr, the Hunyadihalom-Lažňany, the Balaton-Lasinja cultures, as well as the Ludanice, and the Bajč-Retz-Gajary groups). One of the most important indicators of the Transcarpathian influence was the use of various copper objects by local communities and their deposition in graves. A set of seventeen objects, mostly from well-dated grave contexts, was analysed to establish the provenance of the copper artefacts used in western Lesser Poland. This set included artefacts discovered in Złota Grodzisko I and Grodzisko II, Książnice 2, Koniecmosty, Kraków-Wyciąże 5 and Kraków-Cło 7. Energy dispersive X-ray fluorescence analysis was used to study the chemical compositions, while lead isotope ratios were determined using a inductively coupled plasma mass spectrometer (HR-MC-ICP-MS). In addition, some of the objects were visually inspected under a digital microscope to determine how they were made and used. As a result of this analytical programme, it was possible to establish that both Lesser Poland groups used the same copper distribution networks. Initially (c. 4050–3950 BC), the copper originated from the mines in Serbia that at the time were controlled, as suggested in the literature, by the peoples of the Bodrogkeresztúr culture, and also from the mines in the Slovak ore Mountains, linked to the Ludanice group. It appears, however, that from c. 3950 BC onwards, the only source of metal for the production of copper objects used by the inhabitants of western Lesser Poland were the mines located in the Slovak Ore Mountains. This research also suggested that, while around 3950–3800 BC, there was a marked regression in the production and use of copper artefacts in the Carpathian Basin, in the area of western Lesser Poland there was an increase in the use and, most likely, local production of original copper jewellery.
Efficacy of Cytokine Hemoadsorption with Efferon CT in Severe Acute Pancreatitis
Authors: Kiselev V. V. , Zhigalova M. S. , Klychnikova E. V. , Rey S. I. , Yartsev P. A. 
Published: September 2024

The aim of the study was to evaluate the eﬀect of cytokine hemoadsorption on clinical manifestations and laboratory parameters in patients with severe acute pancreatitis (SAP).Materials and methods. The single-center, observational, controlled pilot study included 34 patients, 25 men (73.4%) and 9 women (26.4%), treated for severe acute pancreatitis (SAP) at the N. V. Sklifosovsky Emergency Care Research Institute from May 2022 to August 2023 (ClinicalTrials.gov ID NCT05695001). The mean age of the patients was 42.7±12.6 years. Participants were divided into two groups. In the main group (8 men and 1 woman], mean age 37.2±9.4 years), standard care was supplemented by selective cytokine hemoadsorption (SCH) and renal replacement therapy (RRT) using continuous veno-venous hemoﬁltration (CVVH) in the ﬁrst 72 hours after the onset of abdominal pain syndrome (APS). In the control group (N=25, 18 men and 7 women], mean age 44.7±13.2 years), patients were managed similarly except for SCH.Results. After 24 hours in the ICU, the study group had signiﬁcantly lower levels of lactate (P=0.045) and IL-6 (P<0.001) than the control group. Lactate and IL-6 concentrations remained signiﬁcantly diﬀerent between groups at 72 hours (P<0.001 and P<0.05, respectively). ICU stay was signiﬁcantly shorter in the study group, with a median of 6 days [95% CI, 4–25] before transfer to the general ward, whereas patients in the control group spent 37 days [95% CI, 22–73] in the ICU (P<0.001).Conclusion. CVVH is an eﬀective method of extracorporeal detoxiﬁcation in the management of SAP, but it is less speciﬁc than cytokine adsorption in terms of elimination of proinﬂammatory markers. The data obtained provide suﬃcient evidence to consider the combination of these two modalities as the most eﬀective approach for the management of SAP.
Methodology for Evaluating the Performance of a New Pulse Oximeter Model and Pulse Oximetry Algorithm in Neonates in a Clinical Trial (Exploratory Study)
Authors: Adylov T. S. , Shestak E. V. , Starkov V. Yu. 
Published: September 2024

While evaluating a new domestically produced pulse oximeter model in clinical practice, we discovered a lack of references in Russian-language publications on clinical trial methodologies to assess device reliability and performance.The aim of the study is to create a methodology for conducting a multicenter, prospective, cohort, nonrandomized, controlled clinical trial evaluating a domestic pulse oximeter.Methods. Measurements were performed on 20 preterm infants in the neonatal intensive care unit with a mean birth weight of 2340 [1250; 3125] g and a gestational age of 35 [30; 37] weeks using a new model pulse oximeter simultaneously with the reference monitor. Multiple oxygen saturation measurements of varying duration were taken alternately from the upper and lower limbs, and the number of false desaturation alarms was recorded. Pulse oximeter saturation data were evaluated for correlation with clinical ﬁndings.Results. Attachment of sensors to the infant's feet was found to be optimal in terms of ease of use, minimal artifact generation, and minimal interference with routine medical procedures and neonatal care. To reduce motion-induced artifacts and false alarms, the optimal period of SpO₂ monitoring to detect desaturations and bradycardia was determined to be 120 min. Due to the high variability of pulse rate (PR) and saturation in neonates, two-second intervals were determined to be optimal for comparing records from the two monitors. Matching of ECG HR and pulse oximeter PR was required to eliminate artifacts. A mathematical software model required for accelerated analysis of data collected from all sensors during the study was approved.Conclusion. The data analysis supported the proposed methodology for conducting a clinical trial to evaluate the performance and reliability of new pulse oximetry devices.
Childhood Opportunity Index and Low-Value Care in Children’s Hospitals
Authors: Ugalde Irma T. , Schroeder Alan R. , Marin Jennifer R. , Hall Matt , McCoy Elisha , Goyal Monika K. , Molloy Matthew J. , Stephens John R. , Steiner Michael J. , Tchou Michael J. , Markham Jessica L. , Cotter Jillian M. , Noelke Clemens , Morse Rustin , House Samantha A. 
Published: September 2024

BACKGROUND AND OBJECTIVE
Few studies have explored the relationship between social drivers of health and pediatric low-value care (LVC). We assessed the relationship between Childhood Opportunity Index (COI) 2.0 and LVC in children’s hospitals.

METHODS
We applied the Pediatric Health Information System LVC Calculator to emergency and inpatient encounters from July 2021 through June 2022. Proportions with LVC in highest (greatest opportunity) and lowest COI quintiles were compared. Generalized estimating equation logistic regression models were used to analyze LVC trends across COI quintiles.

RESULTS
842 463 encounters were eligible for 20 LVC measures. Across all measures, odds of LVC increased across increasing COI quintiles (adjusted odds ratio [OR] 1.06, 95% confidence interval [CI] 1.03–1.08). For 12 measures, LVC was proportionally more common in highest versus lowest COI quintile, whereas the reverse was true for 4. Regression modeling revealed increasing LVC as COI increased across all quintiles for 10 measures; gastric acid suppression for infants had the strongest association (OR 1.22, 95% CI 1.17–1.27). Three measures revealed decreasing LVC across increasing COI quintiles; Group A streptococcal testing among children &lt;3 years revealed the lowest OR (0.85, 95% CI 0.73–0.99). The absolute volume of LVC delivered was greatest among low COI quintiles for most measures.

CONCLUSIONS
Likelihood of LVC increased across COI quintiles for 10 of 20 measures, whereas 3 measures revealed reverse trends. High volumes of LVC across quintiles support a need for broad de-implementation efforts; measures with greater impact on children with lower opportunity warrant prioritized efforts.
Hemostasis correction in the treatment and rehabilitation of COVID-19 patients
Authors: Grigoreva К. N. , Gashimova N. R. , Tsibizova V. I. 
Published: September 2024

Background. It is well known that the severe course of a new coronavirus infection (NCI) is often accompanied by a significant risk of hemostasis system disorders. Virus-associated coagulopathy in COVID-19 differs from its other types. Apparently, it is directly related to inflammatory processes and an inadequate response from the immune system.Objective: to determine the main mechanisms of immune-mediated coagulopathy development in NCI patients and methods of correcting this pathological condition.Material and methods. The search for studies devoted to the specifics of coagulopathy course in COVID-19, treatment and rehabilitation of patients with this complication was carried out in international scientific research databases PubMed/ MEDLINE, Google Scholar, ScienceDirect and scientific electronic library (eLibrary). The search depth was 20 years. The results of queries in search engines Yandex and Google were also taken. After selection of publications performed according to PRISMA recommendations, 73 articles were included in the review.Results. A “vicious circle” associated with cytokine storm underlies the pathogenetic mechanisms of immune-mediated thrombosis in COVID-19 patients. A significant role of endothelial dysfunction, extracellular neutrophil traps (NETs), thrombocytopathy and changes in complement system activity is assigned to coagulopathy development. The therapy of this complication is aimed primarily at pathogenetic process. The effectiveness of anticoagulants, anti-inflammatory drugs, antiplatelet agents, drugs aimed at limiting the role of NETs and complement system in thrombosis development was shown. The expediency of preventive use of anticoagulants in COVID-19 patients was considered. Information was provided on the rehabilitation of NCI patients with coagulopathy. The effectiveness of combined anti-inflammatory and anticoagulant therapy in COVID-19 as a component of complex rehabilitation was indicated.Conslusion. Inflammatory processes and immune response play an crucial role in coagulopathy development in NCI patients. The combination of all pathogenetic changes on the part of immune system, inflammatory response and hemostasis system makes it difficult to carry out therapeutic measures. The general scheme of rehabilitation for COVID-19 patients should include three stages, and timely use of combined anti-inflammatory and anticoagulant therapy is also advisable.
Patient routing system in rehabilitation after treatment for oncogynecological pathologies
Authors: Akavova S. A. 
Published: September 2024

Background. In recent years, oncogynecological diseases have been diagnosed more frequently in women of reproductive age. Despite the high efficiency of treatment measures, significant shortcomings in the rehabilitation system for such patients are noted.Objective: to present the continuity and features of the rehabilitation system for patients of oncogynecological profile.Material and methods. This review included 75 relevant publications from authoritative sources that presented unique findings. The search was conducted in Russian and foreign online libraries, databases and search engines. PRISMA recommendations were used for search and screening.Results. Oncogynecological patients need special attention in providing them medical care at the recovery stage. It is important to adhere to the principle of continuity between all steps of rehabilitation system: immediately after treatment, in rehabilitation department, and on outpatient stage. This system has been developed in Russia, but it needs scaling and solving a number of problems, ranging from a shortage of rehabilitation doctors, limited use of promising rehabilitation tools to insufficient provision of psychological assistance and the absence of generally accepted comprehensive rehabilitation system. At the same time, there is sufficient set of traditional and high-tech rehabilitation methods to provide highly specialized care.Conclusion. Aggressive treatment of oncogynecological diseases has a detrimental effect on the general well-being of women, significantly reducing their quality of life. Previously, proper provision of rehabilitation care encountered the rigidity of the system both at methodological and administrative levels. Recently, there have been positive shifts in solving problems of providing care to oncogynecological patients, however, the presented measures are not enough to qualitatively change the situation.