bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactions of the Greater Ontong Java mantle plume component with the Osbourn Trough
Authors: Zhang Guo-Liang , Li Chao 
Published: November 2016

AbstractThe Ontong Java-Manihiki-Hikurangi plateau (OJMHP) is considered to have originated from a starting mantle plume, and have been rifted apart by two spreading ridges. However, the ages of these spreading ridges and their possible interactions with the presumed mantle plume are unclear. The Manihiki-Hikurangi plateau has been rifted apart by the Osbourn Trough which formed the southwestern Pacific crust to the east of the Tonga-Kermadec trench. Here we report Pb-Hf-Os isotopes of the basaltic crust (Site U1365 of IODP Expedition 329) formed by the Osbourn Trough. Linear regression of Re-Os isotopes results in an age of 103.7 ± 2.3 Ma for Site U1365 basalts, indicating that the Manihiki-Hikurangi plateau was rifted apart by the Osbourn Trough with a spreading rate of ~190 mm/yr. The superfast spreading rate supports the Osbourn as an abandoned segment of the early Pacific spreading ridge, which initially overlapped with the giant starting plume. Moreover, the Pb-Hf isotopes of some of Site U1365 basalts show distinct differences from those of the Pacific mid-ocean ridge basalts, while they are similar to the basalts of the Ontong Java and Manihiki plateaus. We suggest that the OJMHP mantle plume components has been involved by the Osbourn spreading center.
Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice
Authors: Lim Lee Wei , Shrestha Smeeta , Or Yu Zuan , Tan Shawn Zheng Kai , Chung Hwa Hwa , Sun Yang , Lim Chew Leng , Khairuddin Sharafuddin , Lufkin Thomas , Lin Valerie Chun Ling 
Published: November 2016

AbstractTetratricopeptide repeat domain 9A (TTC9A) expression is abundantly expressed in the brain. Previous studies in TTC9A knockout (TTC9A−/−) mice have indicated that TTC9A negatively regulates the action of estrogen. In this study we investigated the role of TTC9A on anxiety-like behavior through its functional interaction with estrogen using the TTC9A−/− mice model. A battery of tests on anxiety-related behaviors was conducted. Our results demonstrated that TTC9A−/− mice exhibited an increase in anxiety-like behaviors compared to the wild type TTC9A+/+ mice. This difference was abolished after ovariectomy, and administration of 17-β-estradiol benzoate (EB) restored this escalated anxiety-like behavior in TTC9A−/− mice. Since serotonin is well-known to be the key neuromodulator involved in anxiety behaviors, the mRNA levels of tryptophan hydroxylase (TPH) 1, TPH2 (both are involved in serotonin synthesis), and serotonin transporter (5-HTT) were measured in the ventromedial prefrontal cortex (vmPFC) and dorsal raphe nucleus (DRN). Interestingly, the heightened anxiety in TTC9A−/− mice under EB influence is consistent with a greater induction of TPH 2, and 5-HTT by EB in DRN that play key roles in emotion regulation. In conclusion, our data indicate that TTC9A modulates the anxiety-related behaviors through modulation of estrogen action on the serotonergic system in the DRN.
Noisy galvanic vestibular stimulation induces a sustained improvement in body balance in elderly adults
Authors: Fujimoto Chisato , Yamamoto Yoshiharu , Kamogashira Teru , Kinoshita Makoto , Egami Naoya , Uemura Yukari , Togo Fumiharu , Yamasoba Tatsuya , Iwasaki Shinichi 
Published: November 2016

AbstractVestibular dysfunction causes postural instability, which is prevalent in the elderly. We previously showed that an imperceptible level of noisy galvanic vestibular stimulation (nGVS) can improve postural stability in patients with bilateral vestibulopathy during the stimulus, presumably by enhancing vestibular information processing. In this study, we investigated the after-effects of an imperceptible long-duration nGVS on body balance in elderly adults. Thirty elderly participants underwent two nGVS sessions in a randomised order. In Session 1, participants received nGVS for 30 min twice with a 4-h interval. In Session 2, participants received nGVS for 3 h. Two-legged stance tasks were performed with eyes closed while participants stood on a foam rubber surface, with and without nGVS, and parameters related to postural stability were measured using posturography. In both sessions, the postural stability was markedly improved for more than 2 h after the cessation of the stimulus and tended to decrease thereafter. The second stimulation in Session 1 caused a moderate additional improvement in body balance and promoted the sustainability of the improvement. These results suggest that nGVS can lead to a postural stability improvement in elderly adults that lasts for several hours after the cessation of the stimulus, probably via vestibular neuroplasticity.
A highly efficient, stable, durable, and recyclable filter fabricated by femtosecond laser drilling of a titanium foil for oil-water separation
Authors: Ye Sen , Cao Qiang , Wang Qingsong , Wang Tianyuan , Peng Qing 
Published: November 2016

AbstractIt has been a long standing challenge to efficiently separate oil and water since prehistoric times, and now it has become even more desirable in oily wastewater purification and oil spill cleanup. Here we introduce a super oil–water separation filter with superhydrophilicity and underwater superoleophobicity, fabricated using femtosecond laser micro-hole drilling of a titanium foil. Such a simply-made filter, without any modification, can achieve a separation efficiency exceeding 99% in eight typical oil–water mixtures. It remains highly efficient after 40 cycles of recycling and after suffering erosion by corrosive media. Furthermore, the used filter, polluted with oil, could be recovered by ultraviolet illumination. The flux of filtered water is tunable by simply selecting the aperture of the microhole or the spacing between adjacent microholes. Such advanced functionality is due to roughness and the TiO2 layers on the ablated surface during fabrication. With superhydrophilic and superoleophobic surfaces, this oil-water filer is also suitable for applications in anti-fouling, anti-smudge, anti-fog, and self-cleaning.
The effects of non-self-sustained oscillators on the en-trainment ability of the suprachiasmatic nucleus
Authors: Gu Changgui , Tang Ming , Rohling Jos H. T. , Yang Huijie 
Published: November 2016

AbstractIn mammals, the circadian rhythms of behavioral and physiological activities are regulated by an endogenous clock located in the suprachiasmatic nucleus (SCN). The SCN is composed of ~20,000 neurons, of which some are capable of self-sustained oscillations, while the others do not oscillate in a self-sustainable manner, but show arrhythmic patterns or damped oscillations. Thus far, the effects of these non-self-sustained oscillatory neurons are not fully explored. Here, we examined how the proportion of the non-self-sustained oscillators affects the free running period under constant darkness and the ability to entrain to the light-dark cycle. We find that the proportion does not affect the free running period, but plays a significant role in the range of entrainment. We also find that its effect on the entrainment range depends on the region where the non-self-sustained oscillators are located. If the non-self-sustained oscillatory neurons are situated in the light-sensitive subregion, the entrainment range narrows when the proportion increases. If they are situated in the light-insensitive subregion, however, the entrainment range broadens with the increase of the proportion. We suggest that the heterogeneity within the light-sensitive and light-insensitive subregions of the SCN has important consequences for how the clock works.
Latitude dependence of the solar granulation during the minimum of activity in 2009
Authors: Muller R. , Hanslmeier A. , Utz D. 
Published: November 2016

Context.Knowledge of the latitude variation of the solar granulation properties (contrast and scale) is useful to better understand interactions between magnetic field, convection, differential rotation, and meridional circulation in the solar atmosphere.Aims.We investigated the latitude dependence of the contrast and scale of the solar granulation, with the help of HINODE/SOT blue continuum images taken in the frame of the HOP 79 program, along the central meridian and along the equator on a monthly basis in 2009 during the last solar minimum of activity.Methods.We selected the sharpest images in latitude and longitude intervals. The selected images in all the N-S and E-W scans taken in 2009 were combined to get statistically reliable results.Results.The contrast of the solar granulation decreases towards the poles and the scale increases, but not regularly since a perturbation occurs at around 60° where both quantities return close to their values at the disk center.Conclusions.Such a latitude variation in a period of minimum of activity (2009), is probably not due to magnetic field, neither the quiet magnetic field at the surface, nor the strong magnetic flux tubes associated with active regions, which could be embedded more or less deeply in the convection zone before they reach the surface. The decrease in contrast and increase in scale towards the pole seem to be related to the differential rotation and the perturbation around 60° to the meridional circulation.
La prise en charge respiratoire chez le patient neuromusculaire
Authors: Boussaïd Ghilas , Devaux Christian , Lofaso Frédéric 
Published: November 2016

Une journée consacrée à la prise en charge respiratoire du patient neuromusculaire a été organisée le 16 septembre 2016 par l’AFM-Téléthon, en collaboration avec la SPLF (Société de Pneumologie de Langue Française) et l’Université de Versailles-Saint-Quentin-en-Yvelines (HandiMedex). Cliniciens, scientifiques et industriels ont échangé sur les conséquences engendrées par une ventilation mécanique au quotidien, en mettant l’accent sur L’existant et Le souhaitable.
La Finlande : un héritage génétique idéalement mis en valeur
Authors: Udd Bjarne , Brignol Tuy Nga , Andoni Urtizberea J. 
Published: November 2016

Si la Finlande est souvent assimilée à une « petite » nation du fait de la taille restreinte de sa population, elle n’en est pas moins un géant en matière de myologie. Sa contribution, très originale, à la découverte de nombreuses myopathies et neuropathies héréditaires est là pour le prouver. Rarement pays aura valorisé son patrimoine génétique autant que la patrie de Sibelius. Particulière par les origines de sa population et fière de sa langue non-indo-européenne, la Finlande cultive pourtant une ouverture d’esprit et une volonté de collaboration sans pareilles. Deux qualités très utiles et très appréciées dans le concert international des équipes travaillant dans le domaine neuromusculaire.
Clin d’œil du Dinosaure émérite
Authors: Kaplan Jean-Claude 
Published: November 2016

Aux États-Unis, les associations de familles de DMD sont montées au créneau pour demander l’agrément par la FDA de la première molécule induisant un saut d’exon thérapeutique. Fait sans précédent et méritant un Clin d’œil, elles ont obtenu satifsfaction.
PGC-1α over-expression suppresses the skeletal muscle atrophy and myofiber-type composition during hindlimb unloading
Authors: Wang Jing , Wang Fei , Zhang Peng , Liu Hongju , He Jian , Zhang Chenyu , Fan Ming , Chen Xiaoping 
Published: November 2016

Abstract
Disuse leads to severe muscle atrophy and a slow-to-fast myofiber-type transition. PGC-1α (Peroxisome proliferator-activated receptor γ coactivator 1α) is documented to play an important role in muscle atrophy and slow-twitch myofiber determination. Transcription of atrophy-related Atrogin-1 by FoxO3 can be reduced by PGC-1α. While Smad3 augments FoxO3-induced Atrogin-1 and MuRF1 promoter activity. So PGC-1α, as a transcription co-activator, may regulate hindlimb unloading (HU)-induced myofiber-type transition and muscle atrophy through Smad3. Our results showed that transgenic PGC-1α mice resisted HU-induced muscle loss, atrophy-related genes expression, and slow-to-fast myofiber-type transition. Furthermore, over-expression of PGC-1α resisted the increase in pSmad3 during muscle atrophy in vivo and in vitro. And, PGC-1α over-expression inhibited the expression of atrogenes via suppressing the phosphorylation of Smad3 in vitro. Thus, PGC-1α is effective in regulating myofiber-type transition during HU, and it alleviates skeletal muscle atrophy partially through suppressing the activation of Smad3.
Cloning and expression analysis of a novel tissue-specific dopa decarboxylase mRNA splicing variant in Bombyx mori
Authors: Tsukioka Dai , Izumi Susumu , Adachi Takeshi 
Published: November 2016

Abstract
Dopa decarboxylase (DDC) protein is involved in the synthesis of dopamine and serotonin. Here, we show that in the silkworm Bombyx mori, a novel DDC splicing variant is selectively expressed in the brain and subesophageal ganglia. In Drosophila melanogaster, a neuron-specific isoform of DDC is known to be alternatively spliced in a similar manner.
An open access database for the evaluation of heart sound algorithms
Authors: Liu Chengyu , Springer David , Li Qiao , Moody Benjamin , Juan Ricardo Abad , Chorro Francisco J , Castells Francisco , Roig José Millet , Silva Ikaro , Johnson Alistair E W , Syed Zeeshan , Schmidt Samuel E , Papadaniil Chrysa D , Hadjileontiadis Leontios , Naseri Hosein , Moukadem Ali , Dieterlen Alain , Brandt Christian , Tang Hong , Samieinasab Maryam , Samieinasab Mohammad Reza , Sameni Reza , Mark Roger G , Clifford Gari D 
Published: November 2016

Abstract
In the past few decades, analysis of heart sound signals (i.e. the phonocardiogram or PCG), especially for automated heart sound segmentation and classification, has been widely studied and has been reported to have the potential value to detect pathology accurately in clinical applications. However, comparative analyses of algorithms in the literature have been hindered by the lack of high-quality, rigorously validated, and standardized open databases of heart sound recordings. This paper describes a public heart sound database, assembled for an international competition, the PhysioNet/Computing in Cardiology (CinC) Challenge 2016. The archive comprises nine different heart sound databases sourced from multiple research groups around the world. It includes 2435 heart sound recordings in total collected from 1297 healthy subjects and patients with a variety of conditions, including heart valve disease and coronary artery disease. The recordings were collected from a variety of clinical or nonclinical (such as in-home visits) environments and equipment. The length of recording varied from several seconds to several minutes. This article reports detailed information about the subjects/patients including demographics (number, age, gender), recordings (number, location, state and time length), associated synchronously recorded signals, sampling frequency and sensor type used. We also provide a brief summary of the commonly used heart sound segmentation and classification methods, including open source code provided concurrently for the Challenge. A description of the PhysioNet/CinC Challenge 2016, including the main aims, the training and test sets, the hand corrected annotations for different heart sound states, the scoring mechanism, and associated open source code are provided. In addition, several potential benefits from the public heart sound database are discussed.
node.dating: dating ancestors in phylogenetic trees in R
Authors: Jones Bradley R , Poon Art F Y 
Published: November 2016

Abstract

Summary
Phylogenetic trees encode the evolutionary distances between species or populations. With sufficient information, these evolutionary distances can be rescaled over time to provide estimates of the dates of the most recent ancestors of the species. Here we present the R program node.dating, divergence-time analysis software, which uses a maximum-likelihood method to estimate the dates of the internal nodes of a phylogenetic tree.

Availability and Implementation
node.dating is available as a part of the R v3.30 package ape v4.0 (cran.r-project.org). node.dating is also available in the GitHub repository: https://github.com/brj1/node.dating, along with supplementary software and tests.

Supplementary information
Supplementary data are available at Bioinformatics online.
Isolator: accurate and stable analysis of isoform-level expression in RNA-Seq experiments
Authors: Jones Daniel C. , Kuppusamy Kavitha T. , Palpant Nathan J. , Peng Xinxia , Murry Charles E. , Ruohola-Baker Hannele , Ruzzo Walter L. 
Published: November 2016

AbstractWhile RNA-Seq has enabled great progress towards the goal of wide-scale isoform-level mRNA quantification, short reads have limitations when resolving complex or similar sets of isoforms. As a result, estimates of isoform abundance carry far more uncertainty than those made at the gene level. When confronted with this uncertainty, commonly used methods produce estimates that are often high-variance—small perturbations in the data often produce dramatically different results, confounding downstream analysis. We introduce a new method, Isolator, which analyzes all samples in an experiment in unison using a simple Bayesian hierarchical model. Combined with aggressive bias correction, it produces estimates that are simultaneously accurate and show high agreement between samples. In a comprehensive comparison of accuracy and variance, we show that this property is unique to Isolator. We further demonstrate that the approach of modeling an entire experiment enables new analyses, which we demonstrate by examining splicing monotonicity across several time points in the development of human cardiomyocyte cells.
Ultraviolet and yellow reflectance but not fluorescence is important for visual discrimination of conspecifics byHeliconius erato
Authors: Finkbeiner Susan D. , Fishman Dmitry A. , Osorio Daniel , Briscoe Adriana D. 
Published: November 2016

AbstractToxicHeliconiusbutterflies have yellow hindwing bars that – unlike their closest relatives – reflect ultraviolet (UV) and long wavelength light, and also fluoresce. The pigment in the yellow scales is 3-hydroxy-DL-kynurenine (3-OHK), found also in the hair and scales of a variety of animals. In other butterflies including pierids, which similarly display wing colors that vary in both the UV and the human-visible range, behavioral experiments have indicated that only the UV component is most relevant to mate choice. Whether inHeliconiusbutterflies it is the UV, the human-visible yellow, and/or the fluorescent component of yellow wing coloration that is relevant to mate choice is unknown. In field studies with butterfly paper models we show that both UV and 3-OHK yellow act as signals forH. eratobut attack rates by birds do not differ significantly between the models. Furthermore, measurement of the quantum yield and reflectance spectra of 3-OHK indicates that fluorescence does not contribute to the visual signal under broad-spectrum illumination. Our results suggest that the use of 3-OHK pigmentation instead of ancestral yellow was driven by sexual selection rather than predation.Summary statementHeliconiusbutterflies use a co-opted yellow pigment for communication, while predators are fooled by non-Heliconiusmimics using ancestral yellow pigments.
Developing a tailored RBS linking to BIM for risk management of bridge projects
Authors: Zou Yang , Kiviniemi Arto , Jones Stephen W. 
Published: November 2016

Purpose
The purpose of this paper is to address the current theoretical gap in integrating knowledge and experience into Building Information Model (BIM) for risk management of bridge projects by developing a tailored Risk Breakdown Structure (RBS) and formalising an active link between the resulting RBS and BIM.

Design/methodology/approach
A three-step approach is used in this study to develop a tailored RBS for bridge projects and a conceptual model for the linkage between the RBS and BIM. First, the integrated bridge information model is in concept separated into four levels of contents (LOCs) and six technical systems based on analysis of the Industry Foundation Classes specification, a critical review of previous studies and authors’ project experience. The second step develops a knowledge-based risk database through an extensive collection of risk data, a process of data mining, and further assessment and translation of data. A critical analysis is conducted in the last step to determine on which level the different risks should be allocated to bridge projects and to propose a conceptual model for linking the tailored RBS to the four LOCs and six technical systems of BIM.

Findings
The findings suggest that the traditional method and BIM can be merged as an integrated solution for risk management by establishing the linkage between RBS and BIM. This solution can take advantage of both the traditional method and BIM for managing risks. On the one hand, RBS enables risk information to be stored in a formal structure, used and communicated effectively. On the other hand, some features of BIM such as 3D visualisation and 4D construction scheduling can facilitate the risk identification, analysis, and communication at an early project stage.

Research limitations/implications
A limitation is that RBS is a qualitative technique and only plays a limited role in quantitative risk analysis. As a result, when implementing this proposed method, further techniques may be needed for assisting quantitative risk analysis, evaluation, and treatment. Another limitation is that the proposed method has not yet been implemented for validation in practice. Hence, recommendations for future research are to: improve the quantitative risk analysis and treatment capabilities of this proposed solution; develop computer tools to support the solution; integrate the linkage into a traditional workflow; and test this solution in some small and large projects for validation.

Practical implications
Through linking risk information to BIM, project participants could check and review the linked information for identifying potential risks and seeking possible mitigation measures, when project information is being transferred between different people or forwarded to the next phase.

Originality/value
This study contributes to the theoretical development for aligning traditional methods and BIM for risk management, by introducing a new conceptual model for linking RBS to BIM.
Defining a smart nation: the case of Singapore
Authors: Hoe Siu Loon 
Published: November 2016

Purpose
The purpose of this paper is to identify the key characteristics and propose a working definition of a smart nation.

Design/methodology/approach
A case study of Singapore through an analysis of the key speeches made by senior Singapore leaders, publicly available government documents and news reports since the launch of the smart nation initiative in December 2014 was carried out.

Findings
Just like smart cities, the idea of a smart nation is an evolving concept. However, there are some emerging characteristics that define a smart nation.

Research limitations/implications
The paper provides an initial understanding of the key characteristics and definition of a smart nation at the nascent stage and a foundation for further research on the topic.

Originality/value
This paper contributes to the existing smart cities and smart nation literature by providing insights to the key characteristics of smart nation and proposing a working definition of the term.