bluuebunny/crossref_metadata_2025_split huggingface dataset:
Willingness of patients with diabetes to use an ICT-based self-management tool: a cross-sectional study
Authors: Shibuta Tomomi , Waki Kayo , Tomizawa Nobuko , Igarashi Ayumi , Yamamoto-Mitani Noriko , Yamaguchi Satoko , Fujita Hideo , Kimura Shigeko , Fujiu Katsuhito , Waki Hironori , Izumida Yoshihiko , Sasako Takayoshi , Kobayashi Masatoshi , Suzuki Ryo , Yamauchi Toshimasa , Kadowaki Takashi , Ohe Kazuhiko 
Published: February 2017

ObjectivesTo examine the prevalence of the willingness of patients with diabetes to use a self-management tool based on information and communication technology (ICT) such as personal computers, smartphones, and mobile phones; and to examine the patient characteristics associated with that willingness.Research design and methodsWe conducted a cross-sectional interview survey of 312 adults with diabetes at a university hospital in an urban area in Japan. Participants were classified into 2 groups: those who were willing to use an ICT-based self-management tool and those who were unwilling. Multiple logistic regression analysis was used to identify factors associated with the willingness, including clinical and social factors, current use of ICT, self-management practices, self-efficacy, and diabetes-related emotional distress.ResultsThe mean age of the 312 participants was 66.3 years (SD=11.5) and 198 (63%) were male. Most of the participants (93%) had type 2 diabetes. Although only 51 (16%) currently used ICT-based self-management tools, a total of 157 (50%) expressed the willingness to use such a tool. Factors associated with the willingness included: not having nephropathy (OR=2.02, 95% CI 1.14 to 3.58); outpatient visits once a month or more (vs less than once a month, OR=2.13, 95% CI 1.13 to 3.99); current use of personal computers and/or smartphones (OR=4.91, 95% CI 2.69 to 8.98); and having greater diabetes-related emotional distress (OR=1.10, 95% CI 1.01 to 1.20).ConclusionsApproximately half of the patients showed interest in using an ICT-based self-management tool. Willing patients may expect ICT-based self-management tools to complement outpatient visits and to make self-management easier. Starting with patients who display the willingness factors might optimize programs based on such tools.
Systematic review of pathways for the delivery of allergy services
Authors: Diwakar Lavanya , Cummins Carole , Lilford Richard , Roberts Tracy 
Published: February 2017

ObjectivesThe incidence and prevalence of allergies worldwide has been increasing and allergy services globally are unable to keep up with this increase in demand. This systematic review aims to understand the delivery of allergy services worldwide, challenges faced and future directions for service delivery.MethodsA systematic scoping review of Ovid, EMBASE, HMIC, CINAHL, Cochrane, DARE, NHS EED and INAHTA databases was carried out using predefined inclusion and exclusion criteria. Data on the geographical region, study design and treatment pathways described were collected, and the findings were narratively reported. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines.Results205 publications were screened and 27 selected for review. Only 3 were prospective studies, and none included a control group. There were no eligible publications identified from North America, Africa, Australia and most parts of Asia. Most publications relate to allergy services in the UK. In general, allergy services globally appear not to have kept pace with increasing demand. The review suggests that primary care practitioners are not being adequately trained in allergy and that there is a paucity of appropriately trained specialists, especially in paediatric allergy. There appear to be considerable barriers to service improvement, including lack of political will and reluctance to allocate funds from local budgets.ConclusionsDemand for allergy services appears to have significantly outpaced supply. Primary and secondary care pathways in allergy seem inadequate leading to poor referral practices, delays in patient management and consequently poor outcomes. Improvement of services requires strong public and political engagement. There is a need for well-planned, prospective studies in this area and a few are currently underway. There is no evidence to suggest that any given pathway of service provision is better than another although data from a few long-term, prospective studies look very promising.
Fall-related attendance and associated hospitalisation of children and adolescents in Hong Kong: a 12-year retrospective study
Authors: Lee James Chun-Yin , Tung Keith Tsz-Suen , Li Tim M H , Ho Frederick Ka-Wing , Ip Patrick , Wong Wilfred Hing-Sang , Chow Chun-Bong 
Published: February 2017

ObjectivesThe present study aimed to examine the trends and characteristics of fall-related attendance in accident and emergency department (AED) by injury type and the trend in associated average length of stay (LOS) among children and adolescents in Hong Kong.DesignA retrospective approach was adopted.SettingAED, involving all local public emergency departments from 2001 to 2012.Participants63 557 subjects aged 0–19 years with fall injury record were included in the analysis.Primary outcome measuresFall-related injury number and rates were calculated and reported. Poisson and negative binomial regression models were used to study the trends of injury incidence rate at different body regions.ResultsAED fall-related attendance rate increased significantly with an annual percentage change of 4.45 (95% CI 3.43 to 5.47%, p<0.0001). The attendance number of male subjects was persistently higher than female subjects. The standardised rate of fracture injury increased by 1.31% (95% CI 0.56 to 2.05%, p<0.0001) and that of non-fracture injury increased by 9.23% (95% CI 7.07 to 11.43%, p<0.0001) annually. Upper limb was the most frequently fractured location. It included forearm/elbow, shoulder/upper arm and wrist/hand with descending order of frequency. On the contrary, head was the most frequent non-fracture location, followed by forearm/elbow.ConclusionsThe rates of fall-related attendance have been increasing and still remain high. There were significant increases in non-fracture injuries. Fractures were most frequently found in the upper extremity of a child while the most common non-fracture location was head. It appears that more efforts should be made and preventive measures should be implemented for children and adolescents in Hong Kong.
Improving malodour management in advanced cancer: a 10-year retrospective study of topical, oral and maintenance metronidazole
Authors: George Reena , Prasoona Thotampuri Shanthi , Kandasamy Ramu , Cherian Renitha , Celine Thangarathi , Jeba Jenifer , Murali Shakila , Mathew David 
Published: February 2017

ObjectivesTo explore the relative effectiveness of topical or oral metronidazole used for malodour in necrotic cancers and to propose a protocol for metronidazole usage in managing malodour.MethodsA retrospective case note review of the management of malodour over 10 years comparing outcomes with topical, intermittent and maintenance oral metronidazole.ResultsAmong 179 patients treated for malodour, the commonest primaries were cervical (45%), and head and neck cancers (40%). Outcomes were poor during the period when only topical or intermittent oral metronidazole was used. Topical use gradually decreased (97% vs 55%) and the proportion of patients receiving maintenance oral metronidazole increased (0% in 2003–2004 vs 93% in 2011). Concurrently, there was reduction in documented malodour (12.5% of visits per patient in 2003–2004 vs 1.5% in 2011, p<0.01).ConclusionsOur data support formulary guidelines recommending maintenance metronidazole for recurrent malodour. Dimethyl trisulfide, a product of anaerobic necrosis causes malodour and can attract maggot-producing flies to decaying tissues. Therefore, to reduce anaerobic malodour in vulnerable settings, we propose a ladder for metronidazole titration. High-risk patients should start with 400 mg thrice daily ×7 days and continue 200 mg once daily. The SNIFFF severity (Smell-Nil, Faint, Foul or Forbidding) can guide follow-up dosage: 200 mg once daily to continue for nil or faint smell; breakthrough courses of 400 mg thrice daily ×1 week for foul smell and 2 weeks for forbidding smell, followed by 200 mg once daily.The effectiveness and limitations of maintenance metronidazole and the SNIFFF ladder should be prospectively evaluated.
High-order harmonic and attosecond pulse generations from Rydberg state driven by the spatially inhomogeneous field
Authors: Feng Liqiang , Li Yi , Meng Fanshun , Liu Hang , Castle R. S. 
Published: February 2017

High-order harmonic spectra and attosecond pulse generation from Rydberg atom (He[Formula: see text]) driven by the spatially inhomogeneous field have been theoretically investigated. (i) Firstly, with an electron initially in a single excited Rydberg state (nth), the harmonic yield can be enhanced due to the decreased ionization potential, and a maximum enhancement can be obtained when the initial state is prepared as the third excited state (n = 3). However, the low cutoff energy from the excited state is unbeneficial to the generation of the higher photon pulse. Thus, with the further introduction of the laser chirp, not only the harmonic cutoff is extended, but also the harmonic modulation is reduced. As a result, five super-bandwidths from 63 eV to 267 eV can be found. (ii) Secondly, by preparing the initial state as a coherent superposition of excited state, the harmonic yield can be further enhanced, especially for the coherent superposition of the first and the third (n = 1 + 3) and the second and the fourth (n = 2 + 4) excited states, the harmonic yield is enhanced by 4–8 orders of magnitude compared with the case of the single ground initial state. Furthermore, by properly adding the laser pulse into the spatially inhomogeneous region (gap center [Formula: see text] a.u.) from left [Formula: see text] to right [Formula: see text], much higher cutoff energies can be obtained in the left region. As a consequence, two super-bandwidths of 248 eV and 496 eV can be obtained. Finally, by properly superposing the harmonics, a series of sub-25-as pulses with intensity enhancement of 5–8 orders of magnitude can be produced.
An Integrated Approach Identifies Mediators of Local Recurrence in Head and Neck Squamous Carcinoma
Authors: Citron Francesca , Armenia Joshua , Franchin Giovanni , Polesel Jerry , Talamini Renato , D'Andrea Sara , Sulfaro Sandro , Croce Carlo M. , Klement William , Otasek David , Pastrello Chiara , Tokar Tomas , Jurisica Igor , French Deborah , Bomben Riccardo , Vaccher Emanuela , Serraino Diego , Belletti Barbara , Vecchione Andrea , Barzan Luigi , Baldassarre Gustavo 
Published: February 2017

Abstract
Purpose: Head and neck squamous cell carcinomas (HNSCCs) cause more than 300,000 deaths worldwide each year. Locoregional and distant recurrences represent worse prognostic events and accepted surrogate markers of patients' overall survival. No valid biomarker and salvage therapy exist to identify and treat patients at high-risk of recurrence. We aimed to verify if selected miRNAs could be used as biomarkers of recurrence in HNSCC.
Experimental Design: A NanoString array was used to identify miRNAs associated with locoregional recurrence in 44 patients with HNSCC. Bioinformatic approaches validated the signature and identified potential miRNA targets. Validation experiments were performed using an independent cohort of primary HNSCC samples and a panel of HNSCC cell lines. In vivo experiments validated the in vitro results.
Results: Our data identified a four-miRNA signature that classified HNSCC patients at high- or low-risk of recurrence. These miRNAs collectively impinge on the epithelial–mesenchymal transition process. In silico and wet lab approaches showed that miR-9, expressed at high levels in recurrent HNSCC, targets SASH1 and KRT13, whereas miR-1, miR-133, and miR-150, expressed at low levels in recurrent HNSCC, collectively target SP1 and TGFβ pathways. A six-gene signature comprising these targets identified patients at high risk of recurrences, as well. Combined pharmacological inhibition of SP1 and TGFβ pathways induced HNSCC cell death and, when timely administered, prevented recurrence formation in a preclinical model of HNSCC recurrence.
Conclusions: By integrating different experimental approaches and competences, we identified critical mediators of recurrence formation in HNSCC that may merit to be considered for future clinical development. Clin Cancer Res; 23(14); 3769–80. ©2017 AACR.
ОЦІНКА СІМЕЙНОЇ СИТУАЦІЇ ТА МАТЕРИНСЬКО-ДИТЯЧИХ ВІДНОСИН ОЧИМА ДІТЕЙ МАТЕРІВ, ХВОРИХ НА ПАРАНОЇДНУ ШИЗОФРЕНІЮ
Authors: Driuchenko M. О. 
Published: February 2017

Вивчення особливостей сімейного функціонування та материнсько-дитячих відносин з точки зору дітей матерів, хворих на параноїдну шизофренію (ПШ). На базі психіатричного відділення Закарпатського обласного наркологічного диспансеру протягом 2014 – 2016 рр. обстежено 100 жінок, хворих на ПШ, та 112 їх дітей (12 жінок мали двох дітей). Жінки були обстежені за допомогою клініко-психопатологічного та психодіагностичного методів, діти – з використанням проективної методики «Кінетичний малюнок сімʼї». Визначено тісний зв’язок порушень сімейного функціонування і сприйняття дитиною родинної ситуації з тяжкістю психопатологічної симптоматики у матерів, хворих на ПШ. У дітей, матері яких хворі на ПШ, виявлено значуще нижчі показники сімейного функціонування за шкалою «Сприятлива сімейна ситуація» (середнє значення 0,46±0,16 балів, р<0,01) та значуще вищі показники за шкалами «Тривожність» (0,97±0,24 балів, р<0,01), «Конфліктність у сім'ї» (1,02±0,27 балів, р<0,01), «Почуття неповноцінності у сімейній ситуації» (0,98±0,21 балів, р<0,01), «Ворожість у сімейній ситуації» (0,95±0,21 балів, р<0,01), що свідчить про наявність дисоціації у материнсько-дитячій взаємодії та деформації сімейного функціонування в родинах, де мати хворіє на ПШ. Наявність тяжкого психічного захворювання на ПШ у матері суттєво впливала на стан психоемоційної сфери дитини і спричиняла глибокі порушення сімейного функціонування. Отримані дані були покладені нами в основу розробки системи медико-психологічних заходів оптимізації материнсько-дитячої взаємодії у жінок, хворих на ПШ.
Ganhar a vida. Uma história do barbeiro africano Antonio José Dutra e sua família. Rio de Janeiro, século XIX
Authors: Jeha Silvana 
Published: February 2017

Este artigo versa sobre as artes dos barbeiros sangradores e músicos no Rio de Janeiro oitocentista, centrado na história de um deles: Antonio José Dutra. O texto também esboça traços biográficos de seus herdeiros. O patriarca, “ natural do Reino do Congo”, veio escravizado para o Brasil e obteve alforria no início da década de 1820. Em 1849, quando morreu, possuía uma barbearia, uma banda, 13 escravos e dois imóveis. Era pai de seis filhos naturais, frutos de três relacionamentos. Se por um lado, os filhos não lograram o mesmo sucesso do pai, por outro, o seu legado cultural e financeiro foi fundamental para suas vidas remediadas de negros livres numa sociedade escravista.
Sex Differences in the Performance of Cardiac Computed Tomography Compared With Functional Testing in Evaluating Stable Chest Pain
Authors: Lubbers Marisa , Coenen Adriaan , Bruning Tobias , Galema Tjebbe , Akkerhuis Jurgen , Krenning Boudewijn , Musters Paul , Ouhlous Mohamed , Liem Ahno , Niezen Andre , Dedic Admir , van Domburg Ron , Hunink Miriam , Nieman Koen 
Published: February 2017

Background—
Cardiac computed tomography (CT) represents an alternative diagnostic strategy for women with suspected coronary artery disease, with potential benefits in terms of effectiveness and cost-efficiency.

Methods and Results—

The CRESCENT trial (Calcium Imaging and Selective CT Angiography in Comparison to Functional Testing for Suspected Coronary Artery Disease) prospectively randomized 350 patients with stable angina (55% women; aged 55±10 years), mostly with an intermediate coronary artery disease probability, between cardiac CT and functional testing. The tiered cardiac CT protocol included a calcium scan followed by CT angiography if the Agatston calcium score was between 1 and 400. Patients with test-specific contraindications were not excluded from study participation. Sex differences were studied as a prespecified subanalysis. Enrolled women presented more frequently with atypical chest pain and had a lower pretest probability of coronary artery disease compared with men. Independently of these differences, cardiac CT led in both sexes to a fast final diagnosis when compared with functional testing, although the effect was larger in women (
P
interaction=0.01). The reduced need for further testing after CT, compared with functional testing, was most evident in women (
P
interaction=0.009). However, no sex interaction was observed with respect to changes in angina and quality of life, cumulative diagnostic costs, and applied radiation dose (all
P
interactions≥0.097).

Conclusions—
Cardiac CT is more efficient in women than in men in terms of time to reach the final diagnosis and downstream testing. However, overall clinical outcome showed no significant difference between women and men after 1 year.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01393028.
Early Rehospitalization After Prolonged Intensive Care Unit Stay Post Cardiac Surgery: Outcomes and Modifiable Risk Factors
Authors: Manji Rizwan A. , Arora Rakesh C. , Singal Rohit K. , Hiebert Brett M. , Menkis Alan H. 
Published: February 2017

Background

Prolonged intensive care unit length of stay (pr
ICULOS
) following cardiac surgery (
CS
) in older adults is increasingly common but rehospitalization characteristics and outcomes are understudied. We sought to describe the rehospitalization characteristics and subsequent non‐institutionalized survival of pr
ICULOS
(
ICULOS
≥5 days) patients and identify modifiable risk factors to decrease 30‐day rehospitalization.

Methods and Results

Consecutive patients from January 1, 2000 to December 31, 2011 were analyzed utilizing linked clinical and administrative databases. Logistic regression was used to identify risk factors associated with 30‐day rehospitalization. Out of 9210 consecutive patients discharged from the hospital alive, 596 (6.5%) experienced pr
ICULOS
. Cumulative incidence of rehospitalization for the pr
ICULOS
cohort at 30 and 365 days was 17.5% and 45.6% versus 11.4% and 28.1% for non‐pr
ICULOS
(
P
<0.01). Over 40% of rehospitalizations for the entire cohort occurred within 30 days of discharge costing over $12 million. The most common reasons for rehospitalization were heart failure (in pr
ICULOS
) and infection (in non‐pr
ICULOS
). Rehospitalization within 30 days was associated with a 2.29‐fold risk of poor 1‐year noninstitutionalized survival for the entire cohort. Potentially modifiable factors affecting 30‐day rehospitalization included lack of physician visits within 30 days of discharge (odds ratio 2.11;
P
=0.01), and preoperative anxiety diagnosis (odds ratio 2.20;
P
=0.01).

Conclusions

Pr
ICULOS
patients have high rates of rehospitalization that is associated with an increased rate of poor noninstitutionalized survival. Addressing modifiable risk factors including early postdischarge access to physician services, as well as access to mental health services may improve patient outcomes.
Does Additional Electrogram‐Guided Ablation After Linear Ablation Reduce Recurrence After Catheter Ablation for Longstanding Persistent Atrial Fibrillation? A Prospective Randomized Study
Authors: Kim Tae‐Hoon , Uhm Jae‐Sun , Kim Jong‐Youn , Joung Boyoung , Lee Moon‐Hyoung , Pak Hui‐Nam 
Published: February 2017

Background
Although circumferential pulmonary vein isolation (CPVI) catheter ablation may not be sufficient for long‐standing persistent atrial fibrillation (L‐PeAF), it is not clear which ablation strategy is beneficial in addition to CPVI. We sought to investigate whether additional complex fractionated atrial electrogram (CFAE)‐guided ablation improves clinical outcomes in L‐PeAF patients who exhibit continuous atrial fibrillation (AF) after CPVI and linear ablation (Line).

Methods and Results

This study enrolled 137 L‐PeAF patients (71.4% male, 61.6±10.9 years old) who underwent radiofrequency catheter ablation. We conducted CPVI+Line based on the Dallas lesion set (posterior box+anterior line) after baseline CFAE mapping in all patients. If AF was defragmented (terminated or changed to atrial tachycardia), the procedure was stopped (AF‐Defrag group, n=29). If AF was maintained after CPVI+Line, we mapped the CFAE again and randomly assigned the patient to the CPVI+Line group (n=54) or the additional CFAE ablation group (CPVI+Line+CFAE group, n=54). L‐PeAF was defragmented during CPVI+Line in 21.2% of patients (29/137, AF‐Defrag group). The mean CFAE cycle length was prolonged (
P
<0.001), and CFAE area (CFAE cycle length <120 milliseconds) was reduced (
P
<0.001) after CPVI+Line in the remaining patients. Procedure time was longer in the CPVI+Line+CFAE group than the CPVI+Line group (
P
=0.023), but procedure‐related complication rates did not vary. During 22.3±13.2 months of follow‐up, the clinical recurrence rates were 17.2% in the AF‐Defrag group, 18.5% in the CPVI+Line group, and 32.1% in the CPVI+Line+CFAE group (log rank,
P
=0.166).

Conclusions
Although CPVI+Line reduces and localizes CFAE area, additional CFAE ablation after CPVI+Line does not improve the clinical outcomes of catheter ablation in patients with L‐PeAF.
Social influence and cognitive-motivational effects on terrorism preparedness: A hurdle model
Authors: Wirtz Philip W , Rohrbeck Cynthia A 
Published: February 2017

Objectives: The identification of factors which influence peoples’ preparation for health safety risks posed by natural and man-made disasters is a central concern in health education. Prior studies have generally approached this issue from either a cognitive or a social influence perspective, and have failed to recognise the increased importance of terrorism-related concerns in motivating health safety preparedness behaviour. The purpose of this study was to develop a unified social cognitive framework for understanding peoples’ preparations for health safety risks, focusing on terrorism-related cognitive and social influences. Design/Method/Approach: Participants in the National Survey of Disaster Experiences and Preparedness reported preparedness actions they had taken since 2001, their appraisals of terrorism-related threat and coping, and whether they knew others who had taken preparedness actions because of terrorism. Using a logistic binomial hurdle statistical model, number of actions taken was regressed on terrorism-related vulnerability, severity, response efficacy, self-efficacy, and informational social influence. Simultaneous models both of taking any action and of the number of actions taken were tested. Findings: After controlling for demographic variables, both taking any action and the number of preparedness actions taken were positively related to terrorism-related informational social influence, response efficacy, and self-efficacy; effects of terrorism-related vulnerability and severity appraisals were much smaller. Compared to cognitive factors, terrorism-related informational social influence had a substantially larger effect on taking any action, and a moderately larger effect on the number of actions taken. Conclusion: Terrorist-related informational norms were more salient than cognitive factors in influencing peoples’ preparation for health safety risks. Participants who knew someone who had taken one or more emergency preparedness actions because of terrorism were significantly more likely to take any preparedness action, and to take more preparedness actions, themselves. These findings are consequential in developing future educational initiatives.