bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energy Service Security for Public Health Resilience: Perception and Concerns in Western Upper Peninsula of Michigan☆
Authors: Tiwari Shardul , Ketola Zoē , Schelly Chelsea , Boyer‐Cole Eric 
Published: October 2024

AbstractThe Western Upper Peninsula of Michigan includes six rural counties and one Tribal Nation. The region is characterized by long winters, legacies of the extractive mining economy, and the infrastructural features of extreme rurality, including aging housing and low health service density. The region also faces exceptionally high electricity prices. There is limited research on the public health implications of energy service disruption in rural regions resulting from the increasing intensity and frequency of weather events caused by climate change. This article presents research findings examining the readiness of health facilities in this area to manage the rising intensity, severity, and frequency of severe weather that could disrupt energy services. The study also considers how this knowledge can guide decision‐making to improve energy service access and maintain resilient public health services in the region. This exploratory study utilized a qualitative approach that combines semi‐structured interviews with public health stakeholders and a short survey to triangulate the findings from health facilities. Given the pivotal role of dependable energy services in community health, these findings underscore the community's perception of self‐reliance as both an asset and a hurdle. This perception aligns with the realities of rural communities at the “end of the line” regarding critical infrastructure, which also serves as a formidable barrier to social organization and infrastructure access during energy service disruptions that can severely impact public health.
US suspension policy from the African Growth and Opportunity Act (AGOA): An estimation of the missing exports from sub‐Saharan Africa
Authors: Sorgho Zakaria 
Published: October 2024

AbstractThe African Growth and Opportunity Act (AGOA) is a unilateral duty‐free access program granted by the United States (US) to exports from sub‐Saharan African (SSA) countries. However, provisions of the AGOA text specify that countries can be suspended from the program in case of political turmoil and human rights violations that threaten democracy and the rule of law. This paper constructs a two‐step framework combining matching techniques and gravity regression to quantify the loss of exports due to AGOA suspensions using high‐disaggregated data of exports (10‐digit HTS level) from Africa to the US during 2001–2020. The AGOA suspension resulted in a 54% decline in SSA countries' exports to the US. Estimations suggest that, since 2004, the US suspension policy led to a reduction in exports from suspended countries of approximately 691 million USD on average per year. Over the 17 years (2004–2020), the suspended countries lost a total of 11.7 billion USD in the value of their exports to the US.
Comprehensive Assessment of Dermatologic and Dysmorphic Manifestations in Patients With Down Syndrome
Authors: Kaya Gökhan , Alavanda Ceren 
Published: October 2024

ABSTRACTBackgroundDown syndrome (DS), a common chromosomal anomaly caused by trisomy of chromosome 21, is characterized by a broad spectrum of phenotypic characteristics across multiple organ systems, including cardiac defects and leukemia. Dermatological findings are prevalent among individuals with DS; however, these issues are frequently underrecognized and inadequately researched, resulting in a significant gap in the provision of comprehensive healthcare strategies. Given the increased life expectancy of patients with DS and delayed manifestation of many dermatoses, physicians are increasingly encountering dermatological findings in this population.ObjectiveThis study aimed to assess the prevalence and types of dermatological findings in individuals with DS, compare them with those in a control group, and emphasize the necessity of incorporating dermatological evaluations into routine health monitoring.MethodsThis prospective cross‐sectional study was conducted from June 2023 to June 2024 and involved 100 genetically confirmed individuals with DS and 100 age‐ and sex‐matched controls. Comprehensive demographic, clinical, and karyotype data were collected for the DS group, and all the participants underwent detailed morphological evaluations.ResultsThe DS group had a mean age of approximately 6.37 years, whereas the controls were around 7 years old, with no significant differences in age or sex distribution between the groups. Karyotype analysis showed that trisomy 21 was present in 92% of the cases, mosaicism in 6%, and translocation in 2%. Common dermatological findings in the DS group included xerosis cutis (49%), thin and sparse hair (48%), dental caries (34%), delayed tooth eruption (28%), nail dystrophy (25%), fissured tongue (23%), and cheilitis (18%). Significant differences were noted in the prevalence of scabies, bacterial infections, and café au lait macules between the DS and control groups (p < 0.01). Dysmorphic findings in the DS group included epicanthal folds (97%), upslanted palpebral fissures (97%), brachycephaly (91%), and single transverse palmar crease (89%). Significant gender differences were noted in the prevalence of brachycephaly and the sandal gap (p < 0.01).ConclusionsThis study highlights the importance of regular dermatological care in enhancing the health management and quality of life of individuals with DS due to the prevalence and variability of dermatological conditions.
Relationship Between Cytokines and Face Skin Symptoms in Newborns in Two Japanese Cities
Authors: Yonezawa Kaori , Higuchi Sachi , Shimizu Satsuki , Minematsu Takeo , Haruna Megumi 
Published: October 2024

ABSTRACTAimSeveral skin disorder symptoms may appear in infants, each resulting from a different inflammatory response. In this study, we investigated the relationship between skin cytokine levels and skin symptoms in newborns.MethodsThis cross‐sectional study was conducted in Tokyo and Oita, two Japanese cities. The participants were healthy, 1‐month‐old infants and their parents. Symptoms including erythema, papules, dryness, and exudate/yellow scaling on infant faces were evaluated as outcomes. Cytokine levels (interleukin [IL]‐4, IL‐6, IL‐8, and IL‐17) were measured by skin blotting. A multilevel analysis using a mixed‐effects model was conducted to account for regional differences.ResultsA total of 231 infants (119 from Tokyo and 112 from Oita) participated in this study. Erythema, papules, dryness, and exudate/yellow scaling were present in 59 (25.5%), 133 (57.6%), 37 (16.0%), and 16 (6.9%) of the infants, respectively. In terms of the associations between symptoms and cytokines, there was a significant association between papules and IL‐8 positivity (adjusted odds ratio [AOR]: 1.94, 95% confidence interval [CI] 1.09–3.47) even after adjustment for differences in barrier function, area, and skin care.ConclusionsThis study demonstrated that cytokines were linked to skin conditions, even after accounting for regional differences and genetic factors. This suggests that different symptoms point to the involvement of various cytokines in skin conditions in neonates, with mechanisms varying based on the symptoms. These findings could aid in developing specific preventive strategies in the future.
White NIMBYism and diversity close to home
Authors: Britt Lucy , Jozwiak Andreas 
Published: October 2024

AbstractObjectiveWe use a survey experiment to study what explains white “not in my backyard” opposition (NIMBYism) to dense and affordable housing—racial threat, material self‐interest, or both.MethodsIn a survey experiment on white U.S. respondents, we vary the presence of a racial prime about black and Latinx community organizations and the proximity of the housing development to the subject's home. We then measure levels of support for a proposed hypothetical housing development, willingness to take political action in support of or opposition to the development, and support for a number of housing‐related and redistributive policies.ResultsWe find that a racial threat, a material self‐interest threat, and a combined racial and material self‐interest threat decrease support for a proposed housing development. These effects are moderated by racial resentment, ideology, and partisanship such that the effects of the treatments are primarily driven by Republicans, conservatives, and the highly racially resentful. These groups are more threatened than others by either Latinx and black people moving in, the development being in their own neighborhood, or both.ConclusionThese findings indicate that racial and material perceived threats play important and interlocking roles in white Americans’ resistance to multifamily housing being built. In a context where local political institutions empower an unrepresentative group of disproportionately white, economically privileged neighbors to mount opposition to dense housing, it is important to understand how white opposition to new dense housing is shaped by racial and financial concerns.
Platform Business Groups and the Omni‐Channel Transformation of Food Retailing in China
Authors: Han Zhi , Wood Steve , Coe Neil M. , Alexander Andrew 
Published: October 2024

AbstractIn the past decade, China's food retail market has undergone significant restructuring driven by platform firms, enhancing omni‐channel capabilities across the sector, and bolstering the resilience of domestic retailers. These shifts have contributed to the exit of numerous international food retailers. Despite this transformation, there remains a lack of understanding regarding the economic geography of China's food retail market, especially in terms of digital platform operations. This paper aims to conceptualise two major Platform Business Groups (PBGs), Alibaba Group and Tencent‐JD.com Alliance, and investigate their respective roles in the omni‐channel transformation of Chinese food retailing. Drawing on forty semi‐structured interviews and diverse quantitative and qualitative sources, the study conceptualises two distinct PBG models shaping the market: Alibaba's ‘Integrated PBG’ and the Tencent‐JD.com Alliance's ‘Cooperative PBG’. The research explores how the two groups utilise online analytics directly through foodstore subsidiaries and indirectly by providing omni‐channel digital services to third‐party food retailers.
Global perspectives on donor‐derived infections: Brazil and Argentina
Authors: Song Alice T. W. , Yrbas Maria de los Angeles , Pierrotti Ligia Camera , Malan Richard , Delfino Cecilia , Pontes Daniela Ferreira Salomão , D'Albuquerque Luiz Augusto Carneiro , Andraus Wellington , Abdala Edson 
Published: October 2024

AbstractBrazil and Argentina are two of the South American countries that perform the highest number of solid organ transplant procedures globally each year. These procedures are not exempt from risks for the recipient, and there is a risk of donor‐derived infections. Risk mitigation measures for disease transmission from donor to recipient are essential, and biovigilance systems play a crucial role to inform authorities and provide data for the definition of screening procedures and prevention of donor‐derived infections. We herein describe the biovigilance systems in Brazil and Argentina and provide some data regarding potential and effective donors.
Spike and nucleocapsid antibody dynamics following SARS‐CoV‐2 infection and vaccination: Implications for sourcing COVID‐19 convalescent plasma from routinely collected blood donations
Authors: Di Germanio Clara , Deng Xutao , Balasko Brendan G. , Simmons Graham , Martinelli Rachel , Grebe Eduard , Stone Mars , Spencer Bryan R. , Saa Paula , Yu Elaine A. , Lanteri Marion C , Green Valerie , Wright David , Lartey Isaac , Kleinman Steven , Jones Jefferson , Biggerstaff Brad J. , Contestable Paul , Busch Michael P. 
Published: October 2024

AbstractBackgroundCOVID‐19 convalescent plasma (CCP) remains a treatment option for immunocompromised patients; however, the current FDA qualification threshold of ≥200 BAU/mL of spike antibody appears to be relatively low. We evaluated the levels of binding (bAb) and neutralizing antibodies (nAb) on serial samples from repeat blood donors who were vaccinated and/or infected to inform criteria for qualifying CCP from routinely collected plasma components.MethodsDonors were categorized into four groups: (1) infected, then vaccinated, (2) vaccinated then infected during the delta, or (3) omicron waves, (4) vaccinated without infection. IgG Spike and total Nuclecapsid bAb were measured, along with S variants and nAb titers using reporter viral particle neutralization.ResultsMean S IgG bAb peaks after infection alone were lower than after primary and booster vaccinations, and higher after delta and omicron infection in previously vaccinated donors. Half‐lives for S IgG ranged from 34 to 66 days after first infection/vaccination events and up to 108 days after second events. The levels of S IgG bAb and nAb were similar across different variants, except for omicron, which were lower. Better correlations of nAb with bAb were observed at higher levels (hybrid immunity) than at the current FDA CCP qualifying threshold.DiscussionRoutine plasma donations from donors with hybrid immunity had high S bAb and potent neutralizing activity for 3–6 months after infection. In donations with high (>4000 BAU/mL) S IgG, >95% had high nAb titers (>500) against ancestral and variant S, regardless of COVID‐19 symptoms. These findings provide the basis for test‐based criteria for qualifying CCP from routine blood donations.
Physician perspectives about the diagnosis and management of acute chest syndrome
Authors: Bhasin Neha , LeBlanc Dana Marie , Yates Sean , Eichbaum Quentin , Pham An , Sharma Deva , Zhang Li , Vichinsky Elliott P. , Sarode Ravi 
Published: October 2024

AbstractBackgroundAcute chest syndrome (ACS) is the leading cause of mortality, accounting for 25% of all deaths among individuals with sickle cell disease (SCD). There is a lack of evidence‐based laboratory and clinical risk stratification guidelines for the diagnosis and management of ACS.Study Design and MethodsTo better understand physician practices for the management of ACS in the United States, we created an ACS Working Group including hematology and transfusion medicine physicians from four different SCD treatment centers in the United States. The working group created a physician survey that included physician demographics and ACS diagnostic criteria that they had to rate. The survey also included three case scenarios to assess physician attitudes about the management of ACS. Management options included supportive and preventive strategies in addition to transfusion therapy options.ResultsOut of 455 physicians who received the survey, 195 responded (response rate = 43%). The respondents were primarily hematology/oncology physicians. The responses showed wide variability among physicians in how diagnostic criteria for ACS are used and how physicians risk‐stratify ACS patients in their practice. The responses also reflected variability in the use of transfusions for ACS.DiscussionBased on our results, we conclude that ACS is diagnosed and managed inconsistently among expert physicians, especially in their transfusion practices due to a lack of consensus on risk stratification criteria. Our data suggest an urgent need for well‐designed prospective studies to provide evidence‐based guidelines and minimize management variability among physicians who care for individuals with SCD and ACS.
Serological and molecular characterization of novel ABO variants including an interesting B(A) subgroup
Authors: He Yunlei , Yu Lu , Zhang Jiwei , He Yiwen , Niu Di , Deng Gang 
Published: October 2024

AbstractBackgroundABO grouping is the most important pretransfusion testing that is directly related to the safety of blood transfusion. A weak ABO subgroup is one of the important causes of an ABO grouping discrepancy. Here, we investigated the characterization of four novel ABO variants including a novel B(A) subgroup.Study Design and MethodsRBCs were phenotyped by standard serology methods. The full coding regions of the ABO gene and the erythroid cell‐specific regulatory elements in intron one were sequenced. The effect of the possible splice site variant was predicted by Alamut software. The 3D structural modeling of three relative B(A) enzymes (p.Met214Thr, p.Met214Val, and p.Met214Leu) were performed by PyMOL software.ResultsFour novel ABO alleles were identified with weak ABO expression in this study, in which two would lead to premature terminations, and two resulted in amino acid changes. In silico analysis revealed that the splice site variant c.155G>T had the potential to alter splice transcripts. 3D structural view shown that the variant amino acid position 214 was spatially adjacent to the donor recognition pocket residues (266Met and 268Ala) and just next to the 211DVD213 motif. The size of the side chain of Thr and Val is the smallest, Leu is medium, and Met is the largest, and the size changes in the critical position 214 may affect the donor recognition pocket.ConclusionFour ABO subgroup alleles were newly linked to different kinds of ABO variants and the possible mechanism through which they produce weak ABO subgroups was analyzed in silico.
The excedance quotient of the Bruhat order, quasisymmetric varieties, and Temperley–Lieb algebras
Authors: Bergeron Nantel , Gagnon Lucas 
Published: October 2024

AbstractLet be the ring of polynomials in variables and consider the ideal generated by quasisymmetric polynomials without constant term. It was shown by J. C. Aval, F. Bergeron, and N. Bergeron that the th Catalan number. In the present work, we explain this phenomenon by defining a set of permutations with the following properties: first, is a basis of the Temperley–Lieb algebra , and second, when considering as a collection of points in , the top‐degree homogeneous component of the vanishing ideal is . Our construction has a few byproducts that are independently noteworthy. We define an equivalence relation on the symmetric group using weak excedances and show that its equivalence classes are naturally indexed by noncrossing partitions. Each equivalence class is an interval in the Bruhat order between an element of and a 321‐avoiding permutation. Furthermore, the Bruhat order induces a well‐defined order on . Finally, we show that any section of the quotient gives an (often novel) basis for .
Repeated passive heat treatment increases muscle tissue capillarization, but does not affect postprandial muscle protein synthesis rates in healthy older adults
Authors: Fuchs Cas J. , Betz Milan W. , Petrick Heather L. , Weber Jil , Senden Joan M. , Hendriks Floris K. , Bels Julia L.M. , van Loon Luc J.C. , Snijders Tim 
Published: October 2024

AbstractProlonged passive heat treatment (PHT) has been suggested to trigger skeletal muscle adaptations that may improve muscle maintenance in older individuals. To assess the effects of PHT on skeletal muscle tissue capillarization, perfusion capacity, protein synthesis rates, hypertrophy and leg strength, 14 older adults (9 males, 5 females; 73 ± 6 years) underwent 8 weeks of PHT (infrared sauna: 3× per week, 45 min at ∼60°C). Before and after PHT we collected muscle biopsies to assess skeletal muscle capillarization and fibre cross‐sectional area (CSA). Basal and postprandial muscle tissue perfusion kinetics and protein synthesis rates were assessed using contrast‐enhanced ultrasound and primed continuous l‐[ring‐13C6]phenylalanine infusions, respectively. One‐repetition maximum (1RM) leg strength and vastus lateralis muscle CSA were assessed. Type I and type II muscle fibre capillarization strongly increased following PHT (capillary‐to‐fibre perimeter exchange index: +31 ± 18 and +33 ± 30%, respectively; P < 0.001). No changes were observed in basal (0.24 ± 0.27 vs. 0.18 ± 0.11 AU; P = 0.266) or postprandial (0.20 ± 0.12 vs. 0.18 ± 0.14 AU; P = 0.717) microvascular blood flow following PHT. Basal (0.048 ± 0.014 vs. 0.051 ± 0.019%/h; P = 0.630) and postprandial (0.041 ± 0.012 vs. 0.051 ± 0.024%/h; P = 0.199) muscle protein synthesis rates did not change in response to prolonged PHT. Furthermore, no changes in vastus lateralis muscle CSA (15.3 ± 4.6 vs. 15.2 ± 4.6 cm2; P = 0.768) or 1RM leg strength (46 ± 12 vs. 47 ± 12 kg; P = 0.087) were observed over time. In conclusion, prolonged PHT increases muscle tissue capillarization but this does not improve muscle microvascular blood flow or increase muscle protein synthesis rates in healthy, older adults. Prolonged PHT does not induce skeletal muscle hypertrophy or increase leg strength in healthy, older adults.
imageKey points
Repeated exposure to heat has been suggested to trigger skeletal muscle adaptive responses.
We investigated the effect of 8 weeks of whole‐body passive heat treatment (PHT; infrared sauna: 3× per week for 45 min at ∼60°C) on skeletal muscle tissue capillarization, perfusion capacity, basal, and postprandial muscle protein synthesis rates, muscle (fibre) hypertrophy, and leg strength in healthy, older adults.
Prolonged PHT increases muscle tissue capillarization, but this does not improve muscle microvascular blood flow or increase muscle protein synthesis rates.
Despite increases in muscle tissue capillarization, prolonged PHT does not suffice to induce skeletal muscle hypertrophy or increase leg strength in healthy, older adults.
Effects of Training With Different Hang-Power-Clean Intensities on the Maximum Dynamic Strength, Vertical Jump, and Sprint Performance of Female Handball Players
Authors: Silva Claudio , Berton Ricardo , Boccato João , Tricoli Valmor 
Published: October 2024

Purpose: To compare the effects of 7 weeks of training with different hang-power-clean (HPC) intensities on the maximum dynamic strength, vertical jump, and sprint performance of female handball players. Methods: Professional handball athletes with at least 1 year of HPC experience volunteered to participate. The athletes were balanced by position and randomly assigned to a group with HPC at 90% (HPC90%) or 50% (HPC50%) of HPC 1-repetition maximum (1RM). The training volume was equalized between groups. Pretraining and posttraining assessments included 1RM HPC, jump height in the squat jump (SJ) and countermovement jump (CMJ), and sprint speeds at 5, 20, and 30 m. Results: From pretraining to posttraining, both groups significantly increased (P ≤ .05) 1RM HPC, although a small effect size was observed in favor of HPC90%. HPC90% and HPC50% did not induce significant changes (P > .05) in the SJ and CMJ height, although for the SJ, a small effect size was observed in favor of HPC90%. Both groups induced a significant improvement (P ≤ .05) in 5-, 20-, and 30-m sprint speeds, although for all speeds, small to moderate effect sizes were observed in favor of HPC90%. Conclusions: Both training groups induced significant improvements in 1RM HPC and sprint speeds, whereas no significant changes were observed in vertical jumps. In addition, based mainly on the effect sizes, the HPC90% group was more effective for increasing 1RM HPC, SJ, and sprint speeds than the HPC50% group.