bluuebunny/crossref_metadata_2025_split huggingface dataset:
Umbilical Cord Mesenchymal Stromal Cell With Autologous Bone Marrow Cell Transplantation in Established Type 1 Diabetes: A Pilot Randomized Controlled Open-Label Clinical Study to Assess Safety and Impact on Insulin Secretion
Authors: Cai Jinquan , Wu Zhixian , Xu Xiumin , Liao Lianming , Chen Jin , Huang Lianghu , Wu Weizhen , Luo Fang , Wu Chenguang , Pugliese Alberto , Pileggi Antonello , Ricordi Camillo , Tan Jianming 
Published: December 2015

OBJECTIVE
To determine the safety and effects on insulin secretion of umbilical cord (UC) mesenchymal stromal cells (MSCs) plus autologous bone marrow mononuclear cell (aBM-MNC) stem cell transplantation (SCT) without immunotherapy in established type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS
Between January 2009 and December 2010, 42 patients with T1D were randomized (n = 21/group) to either SCT (1.1 × 106/kg UC-MSC, 106.8 × 106/kg aBM-MNC through supraselective pancreatic artery cannulation) or standard care (control). Patients were followed for 1 year at 3-month intervals. The primary end point was C-peptide area under the curve (AUCC-Pep) during an oral glucose tolerance test at 1 year. Additional end points were safety and tolerability of the procedure, metabolic control, and quality of life.

RESULTS
The treatment was well tolerated. At 1 year, metabolic measures improved in treated patients: AUCC-Pep increased 105.7% (6.6 ± 6.1 to 13.6 ± 8.1 pmol/mL/180 min, P = 0.00012) in 20 of 21 responders, whereas it decreased 7.7% in control subjects (8.4 ± 6.8 to 7.7 ± 4.5 pmol/mL/180 min, P = 0.013 vs. SCT); insulin area under the curve increased 49.3% (1,477.8 ± 1,012.8 to 2,205.5 ± 1,194.0 mmol/mL/180 min, P = 0.01), whereas it decreased 5.7% in control subjects (1,517.7 ± 630.2 to 1,431.7 ± 441.6 mmol/mL/180 min, P = 0.027 vs. SCT). HbA1c decreased 12.6% (8.6 ± 0.81% [70.0 ± 7.1 mmol/mol] to 7.5 ± 1.0% [58.0 ± 8.6 mmol/mol], P &lt; 0.01) in the treated group, whereas it increased 1.2% in the control group (8.7 ± 0.9% [72.0 ± 7.5 mmol/mol] to 8.8 ± 0.9% [73 ± 7.5 mmol/mol], P &lt; 0.01 vs. SCT). Fasting glycemia decreased 24.4% (200.0 ± 51.1 to 151.2 ± 22.1 mg/dL, P &lt; 0.002) and 4.3% in control subjects (192.4 ± 35.3 to 184.2 ± 34.3 mg/dL, P &lt; 0.042). Daily insulin requirements decreased 29.2% in only the treated group (0.9 ± 0.2 to 0.6 ± 0.2 IU/day/kg, P = 0.001), with no change found in control subjects (0.9 ± 0.2 to 0.9 ± 0.2 IU/day/kg, P &lt; 0.01 vs. SCT).

CONCLUSIONS
Transplantation of UC-MSC and aBM-MNC was safe and associated with moderate improvement of metabolic measures in patients with established T1D.
Determinants of Diabetes Remission and Glycemic Control After Bariatric Surgery
Authors: Panunzi Simona , Carlsson Lena , De Gaetano Andrea , Peltonen Markku , Rice Toni , Sjöström Lars , Mingrone Geltrude , Dixon John B. 
Published: December 2015

OBJECTIVE
Eligibility criteria for bariatric surgery in diabetes include BMI ≥35 kg/m2 and poorly controlled glycemia. However, BMI does not predict diabetes remission, and thus, predictors need to be identified.

RESEARCH DESIGN AND METHODS
Seven hundred twenty-seven patients were included in a database merged from the Swedish Obese Subjects (SOS) study and two randomized controlled studies, with 415 surgical and 312 medical patients in total. Bariatric operations were divided into gastric only (GO) and gastric plus diversion (GD).

RESULTS
Sixty-four percent of patients in the surgical arm and 15.0% in the medical arm experienced diabetes remission (P &lt; 0.001). GO yielded 60% remission, and GD yielded 76% remission. The best predictors of diabetes remission were lower baseline glycemia and shorter diabetes duration. However, when operation type was considered, GD predicted a higher likelihood of remission and greater weight loss. Patients in remission (responders) lost more weight (25% vs. 17%) and waist circumference (18% vs. 13%) and experienced better insulin sensitivity than nonresponders.

CONCLUSIONS
Surgery is more effective than medical treatment in achieving diabetes remission and tighter glycemic control. Shorter diabetes duration, lower fasting glycemia before surgery, and GD versus GO procedures independently predict higher rates of remission, whereas baseline HbA1c and waist circumference predict improved glycemic control. The results show the advantage of an early operation together with better controlled glycemia on diabetes remission independently of BMI.
Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study
Authors: Henson Joseph , Davies Melanie J. , Bodicoat Danielle H. , Edwardson Charlotte L. , Gill Jason M.R. , Stensel David J. , Tolfrey Keith , Dunstan David W. , Khunti Kamlesh , Yates Thomas 
Published: December 2015

OBJECTIVE
To determine whether breaking up prolonged sitting with short bouts of standing or walking improves postprandial markers of cardiometabolic health in women at high risk of type 2 diabetes.

RESEARCH DESIGN AND METHODS
Twenty-two overweight/obese, dysglycemic, postmenopausal women (mean ± SD age 66.6 ± 4.7 years) each participated in two of the following treatments: prolonged, unbroken sitting (7.5 h) or prolonged sitting broken up with either standing or walking at a self-perceived light intensity (for 5 min every 30 min). Both allocation and treatment order were randomized. The incremental area under the curves (iAUCs) for glucose, insulin, nonesterified fatty acids (NEFA), and triglycerides were calculated for each treatment condition (mean ± SEM). The following day, all participants underwent the 7.5-h sitting protocol.

RESULTS
Compared with a prolonged bout of sitting (iAUC 5.3 ± 0.8 mmol/L ⋅ h), both standing (3.5 ± 0.8 mmol/L ⋅ h) and walking (3.8 ± 0.7 mmol/L ⋅ h) significantly reduced the glucose iAUC (both P &lt; 0.05). When compared with prolonged sitting (548.2 ± 71.8 mU/L ⋅ h), insulin was also reduced for both activity conditions (standing, 437.2 ± 73.5 mU/L ⋅ h; walking, 347.9 ± 78.7 mU/L ⋅ h; both P &lt; 0.05). Both standing (−1.0 ± 0.2 mmol/L ⋅ h) and walking (−0.8 ± 0.2 mmol/L ⋅ h) attenuated the suppression of NEFA compared with prolonged sitting (−1.5 ± 0.2 mmol/L ⋅ h) (both P &lt; 0.05). There was no significant effect on triglyceride iAUC. The effects on glucose (standing and walking) and insulin (walking only) persisted into the following day.

CONCLUSIONS
Breaking up prolonged sitting with 5-min bouts of standing or walking at a self-perceived light intensity reduced postprandial glucose, insulin, and NEFA responses in women at high risk of type 2 diabetes. This simple, behavioral approach could inform future public health interventions aimed at improving the metabolic profile of postmenopausal, dysglycemic women.
The role of real time three-dimensional transoesophageal echocardiography in acquired mitral valve disease
Authors: Drąsutienė Agnė , Aidietienė Sigita , Zakarkaitė Diana 
Published: December 2015

Summary
Real time (RT) three-dimensional (3D) imaging is one of the most significant developments of the last decade and is now being used with increasing frequency in echocardiography and interventional cardiology laboratories. Improvements in transducer technologies and the development of a matrix array transducer were the most important achievements that lead to the new era of real time 3D transoesophageal echocardiography (TEE). RT 3D TEE is ideal for assessing the mitral valve (MV) because of its high spatial resolution altering in improved MV anatomic detail. This imaging modality provides images of high quality which is of a great clinical value inmaking diagnosis of MV disease and a valuable tool for surgeons and interventional cardiologists in planning and guiding interventional procedures. This review is intended to provide data about normal MV anatomy and clinical usefulness of RT 3D TEE in defining acquired MV pathology.
Shear Tests and Calculation of Shear Resistance with the PC Program RFEM from Thin Partition Walls of Brick in Old Buildings
Authors: Korjenic Sinan , Nowak Bernhard , Löffler Philipp , Vašková Anna 
Published: December 2015

Abstract
This paper is about the shear capacity of partition walls in old buildings based on shear tests which were carried out under real conditions in an existing building. There were experiments conducted on different floors and in each case, the maximum recordable horizontal force and the horizontal displacement of the respective mortar were measured. At the same time material studies and material investigations were carried out in the laboratory. The material parameters were used for the calculation of the precise shear capacity of each joint. In the shear tests, the maximum displacement of a mortar joint was determined at a maximum of two to four millimetres. Furthermore, no direct linear relationship between the theoretical load (wall above it) and the shear stress occurred could be detected in the analysis of the experiment, as it was previously assumed.
Assessment of Soil-Structure Interaction in Seismic Bridge Pier Analysis Using Force and Displacement Based Approaches
Authors: Singh R N P , Vinayak Hemant Kumar 
Published: December 2015

Abstract
The seismic analysis carried out assuming foundation to be perfectly rigid and bonded to the soil underneath is far from truth and therefore, the soil-structure interaction effect on the dynamic behavior of the bridge pier should be considered. The assessment of soil-structure effect on the design force generated has been estimated using Force based, Capacity Spectrum and Direct Displacement based methods considering fixed and flexible foundations. For this purpose a single cantilever bridge pier of constant diameter with varying heights has been considered for the analysis in different type of soils and earthquake zones. The study has revealed that soil-Structure Interaction index is negative in some cases, especially in soft soil, implying base shear demand being greater than that of fixed base contrary to the traditional views.
Comparison of Vertical Light Wooden Constructions Insulated by Straw Bales
Authors: Kováč Miloslav 
Published: December 2015

Abstract
The main task of configuring engineer by designing enclosure construction is to setup performances of the wall to the best options for existing conditions of the structure. Selecting and adjusting bearing elements of perimeter wall is the first step, however appropriateness and position of chosen materials has major influence on technical properties and architectural expression of structure. Besides light vertical constructions (LVC) there are light wooden constructions from glued elements (LPVC), heavy vertical constructions (HVC) and prefabricated vertical constructions (PVC). All types have specifications allowing alternatives in terms of layer structure and bearing elements position. Each type is considered in terms of: structure – 2D drawing and 3D model, thermal insulation, overall heat transfer coefficient, architectural examination.
Journey Into Filter Cakes: A Microstructural Study
Authors: Li D. , He W. 
Published: December 2015

Abstract
Filter cakes are the key to maximizing return permeability and preventing formation damage. Typical considerations of filtercake properties include thickness, toughness, and slickness; however, a filter cake's structure, particle size distribution, texture, and invasion into the formation are also essential factors that can affect the production of oil or gas in a reservoir. This study was conducted to investigate filter cakes and its interactions with rocks through petrographic studies. The filter cakes were created via return permeability tests using actual reservoir or replaced cores. The information and data gathered increases understanding of the damage mechanism a fluid can have on the reservoir.
Our data demonstrates that an improperly sized bridging package, filter-cake compactness, filter-cake invasion, and the inability for a filter cake to create flow channels are key factors that significantly affect return permeability results. Undersized bridging particles can cause filter-cake invasion, permanently block pores within the formation, and limit production flow. Highly compacted filter cakes composed of fine-grained material could act as a barrier between the formation and the wellbore, which can result in a deceased return permeability measurement. Furthermore, filter-cake structures and homogeneity can indicate reservoir drill-in fluid (RDF) stability. Particle separation, according to grain size and/or density, in the drilling fluid can lead to graded particles within the filter cake; this can also ultimately affect production flow.
Investigating the Dominant Factors Influencing Well Screenouts for Crosslinked Fracturing Fluids in Shale Plays
Authors: Inyang U. , Cortez J. , Singh D. , Orth J. , Fontenelle L. , Kishore T. 
Published: December 2015

Abstract
One of the properties of guar borate complexed gel systems is the ability to recover dynamic viscosity after being subjected to high shear. This phenomenon is typically referred to as shear rehealing; and the ease of use of guar borate fluids during hydraulic fracturing operations can be partly attributed to this property. While many metal crosslinked fracturing fluid systems exist, and many provide higher proppant pack permeability after well cleanup, their overall use is lower because of higher cost, operational complexity, and perceived higher screenout rates. This paper examines laboratory and operational data to help parse the primary influences of screenouts for different fracturing fluid systems.
Extensive laboratory experiments investigating low to moderate shear viscosity tendencies of fluids as well as the low shear proppant transport properties of various fracturing fluid systems were performed to determine if there is a strong correlation between fluid flow properties and proppant transport under shear. The operational data reviewed includes wells with similar completion methods, such as completion tools and well construction methods, and the performance of the tested fluids in the field. Experimental data shows proppant transport under low to moderate shear is possible with all of the fluids investigated, and screenout rates did not show significant correlation to the type of fluid used. The decreased ability for shear rehealing is typically associated with higher bottom hole treating pressure and screenout rates of metal crosslinked fluid systems.
In many cases, operators are choosing simplicity of operations over the benefits of using higher quality fracturing fluids. This paper also discusses some of the factors that can help promote surface efficiency, while using the optimal fracturing fluids for the specific well.
Early Steps Towards Laboratory Evaluation of Diversion in Hydraulic Fractures
Authors: Cortez-Montalvo Janette , Vo Loan , Inyang Ubong , Parton Chris , Fulton Dwight 
Published: December 2015

Abstract
Advancements in diversion technology in recent years have made horizontal, multistage fracturing more reliable. Diversion treatments help generate and maintain complexity within generated fracture networks and can lead to more thorough reservoir stimulation. This facilitates maximized stimulation volumes and, potentially, increased production. With industry accepted benefits of the method, diversion technologies have been applied in both primary and refracturing operations. Even with broad adoption of fluid diversion techniques, limited reports of dynamic testing of diversion processes or chemicals under laboratory conditions exist. This paper describes a laboratory testing apparatus designed to dynamically probe the underlying mechanistic and chemical variables that influence near wellbore diversion against a consolidated proppant pack. This apparatus allows some of the critical parameters of diversion to be evaluated independently. In this study, early steps were taken to gain some understanding of the contributing parameters, such as diverter concentration, temperature, and pressure, and how they may influence diverter effectiveness. The laboratory setup in this study aims to conceptualize near wellbore diversion against a consolidated proppant pack with the ultimate goal of expanding the methodology to simulate real-life operation of a diversion treatment on fractures. This apparatus can help determine effects of chemical components and size distribution during successful diversion placement. In addition, some of the effects of temperature, pressure, and flow rates on diversion operations are presented. This dynamic study of diverters provided more insight into understanding factors that affect diversion, and provided data that can help optimize future diversion treatments.
It is widely acknowledged that diversion technology has significant impact in fracturing applications. By initiating the development of a viable lab scale apparatus for diversion chemical testing, greater understanding of how to implement optimized chemical formulations and engineering methods for more effective fluid diversion operations can be gained.
Borehole-to-Surface TFEM Technique Applications in Geologically Complex Areas
Authors: He Zhanxiang , Yu Gang , Zhao Guo , He Tiezhi 
Published: December 2015

Abstract
Borehole-to-surface time-frequency domain electromagnetic (TFEM) method has been applied in delineating oil/gas and water boundary. The technique has achieved significant improvements over the past 10 years and has become an important technique for oilfield development. Recently this method has been applied in a newly found oil and gas target in a mountainous area in the western plateau of China. Due to the complexity of the oilfield development area, some new technical measures have been taken when using the TFEM technique, such as multi-well joint operation program, multi-source excitement for multi-target layers, terrain correction, and then extracting effective induced polarization anomalies and high resistivity anomalies through dual frequency amplitude and tri-band phase anomaly. Drilling results have confirmed the effectiveness of the borehole-to-surface TFEM method in this oilfield. Based on the integrated interpretation result, confirmed oil-bearing areas within the oilfield are enlarged and provided very important basis for the selection of hydrocarbon reservoir delineation wells.
The borehole-to-surface TFEM survey results show that joint operation program of multiple source wells can evaluate relatively large area of traps. Multiple downhole source positions and graded source excitation can be used for detecting multi-target layers. A simple data processing method can depress terrain's effect, and then the high polarization anomalies and high resistivity anomalies reflecting hydrocarbon reservoirs are effectively extracted using the dual frequency amplitude anomaly and tri-band phase anomaly. Finally, potential hydrocarbon accumulation areas can be effectively evaluated and mapped. Drilling results have confirmed the validity of the method and this method provides an effective means for the delineation of hydrocarbon boundary and the selection of evaluation wells in newly developing oilfields.
Coupling Integrated Data Management with Reservoir Surveillance Workflows for Giant Mature Field in Qatar
Authors: Khalifa O. M. , Rais T. A. M , El Maadi A. , Abdullah Sani R. , Mahrous E. K. , Al-Marri Balsam 
Published: December 2015

Abstract
Dukhan, a giant mature onshore field in Qatar, presents a unique challenge to manage multidimensional data within surveillance workflows. A unified data infrastructure is the key enabler for proper field performance monitoring, bridging operational locations to decision-making centers. In this respect, Qatar Petroleum (QP) is integrating reservoir and data management workflows into a single hub that shifts linear workflows into real-time decision-making and action-oriented processes. The strategic advantage of this approach is to provide technology and data real-time, readily available for the key decision-makers. As a strategic initiative, implementation has presented unique challenges in infrastructure modification and technology uptake.
The envisaged solution architecture lies on capabilities of QP's workflows in delivering web components, leveraging multifunctional collaboration, and closing operational gaps within the surveillance workflows. The solution is delivered through a unified platform where periodic/sporadic production information is tied to asset operational models across different sub-systems integrating all surveillance workflows.
The benefits include a fully collaborative environment, a solid data management system to enable timely decisions, and improved shortfall management. Integrating people and processes with the right balance of technology results in enhanced operational efficiencies and recoveries. Despite challenges, QP has gained significant advantages in early adoption and development of this technology, and its implementation has revolutionized the approach to surveillance. In view of the above, the combination of the above aspects resulted in significant increase in compliances, minimized mitigation turnaround time and generated better collaboration within operating units.
This paper describes experiences and challenges of QP project from conception through implementation integrating people and process with the right balance of technology across field operations and how it has resulted in enhanced operational efficiency and production recovery with full asset awareness.
2 1/8-in. Intelligent Coiled Tubing System Improves Operational Efficiency
Authors: Livescu S. , Blanco D. A. , Vacik L. 
Published: December 2015

Abstract
A recently developed 2 ?-in. intelligent coiled tubing (ICT) system combines real-time downhole data monitoring with the capability to simultaneously provide downhole power, significantly improving operational efficiency and accelerating well recovery in all types of CT operations. From milling, stimulation, and well cleanouts to gas lifting, camera services, logging and perforating operations, this novel system can provide accurate, real-time downhole monitoring of high-resolution depth correlation, differential pressure, and temperature data.
The real-time ICT system consists of a non-intrusive electrical conductor wire, surface hardware and software, and a versatile 2 ?-in. bottomhole assembly (BHA) that incorporates the conductor release assembly, casing collar locator (CCL), pressure, and temperature sensor package, and BHA release function. Switching between different applications is as simple as changing out the BHA, which reduces the need to rig-up and rig-down and leads to operational time and cost savings. The main advantage of this system is that it eliminates the downhole uncertainties. For instance, using the real-time downhole depth, pressure, and temperature data, the CT field crew can react to changing conditions, make decisions based on dynamic downhole events, and eliminate missed or wasted runs.
Several case studies have been recently presented in an accompanying paper (SPE-174850). They involved an ICT conveyed camera operation in North America; a complex cement milling, cleanout, and perforating operation in Netherlands; an inflatable plugs setting operation in Brazil; a complex drifting, logging, jetting, zonal isolation, and scale removal operation in Brazil; and a matrix acidizing operation in Brazil. In this paper, several other representative cases are presented. First, an ICT system was used in a newly drilled well in Middle East to cut a stuck drill pipe. Second, an operation for creating a thief zone and matrix acidizing was performed in a deepwater well in Brazil. Third, a complex cleanout, milling, selective perforating, and acid stimulating operation was performed in a horizontal producer in North Sea.
The paper reviews the real-time ICT system and discusses the data acquired during these field operations. The system performance and benefits confirmed during the three operations are presented. These findings outline the versatility of the 2 ?-in. ICT system, the predictability of successful operations resulting from using this system, and the cost and time savings for operators.