bluuebunny/crossref_metadata_2025_split huggingface dataset:
Achieving Sustainable Development by Collaborating in Green Product Innovation
Authors: Melander Lisa 
Published: May 2017

AbstractCollaboration in green product innovation (GPI) is becoming increasingly important, and research on such innovation has grown in recent years. This study reviews literature on external collaborations in GPI to investigate drivers, inter‐organizational factors and intra‐organizational factors for such collaborations. The review includes a total of 67 papers. Survey studies and case studies are the methodologies applied most in the reviewed papers. The most common collaborators are suppliers and customers. Drivers include economic factors, regulations, customer demand, competitiveness and firm performance. Numerous inter‐organizational collaboration factors are presented and summarized in terms of partner selection, relationship management, knowledge access and agreements. Intra‐organizational factors mainly concern cross‐functional collaboration, capabilities and internal practices. Implications for policy and practitioners are presented. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Modulation of CD11c+ lung dendritic cells in respect to TGF‐β in experimental pulmonary fibrosis
Authors: Chakraborty Kaustav , Chatterjee Soumya , Bhattacharyya Arindam 
Published: May 2017

AbstractIdiopathic pulmonary fibrosis (IPF) is a deadly, progressive lung disease with very few treatment options till now. Bleomycin‐induced pulmonary fibrosis (BIPF) is a commonly used mice model in IPF research. TGF‐β1 has been shown to play a key role in pulmonary fibrosis (PF). Dendritic cell (DC) acts as a bridge between innate and adaptive immune systems. The coexistence of chronic inflammation sustained by mature DCs with fibrosis suggests that inflammatory phenomenon has key importance in the pathogenesis of pulmonary fibrosis. Here, we investigated the modulation of DCs phenotypic maturation, accumulation in lung tissue, and expression of other lung DC subsets in respect to TGF‐β in PF. First, we established BIPF model in mice and blocked TGF‐β expression by the use of inhibitor SB431542. Accumulation of lung CD11c+ DCs is significantly higher in both inflammatory and fibrotic phases of the disease but that percentages got reduced in the absence of TGF‐β. TGF‐β initiates up‐regulation of costimulatory molecules CD86 and CD80 in the inflammatory phases of the disease but not so at fibrotic stage. Expression of lung DC subset CD11c+CD103+ is significantly increased in inflammatory phase and also in fibrotic phase of BIPF. Blocking of TGF‐β causes decreased expression of CD11c+CD103+ DCs. Another important lung DC subset CD11c+CD11b+ expression is suppressed by the absence of TGF‐β after bleomycin administration. CD11c+CD103+ DCs might have anti‐inflammatory as well as anti‐fibrotic nature in PF. All these data demonstrate differential modulation of CD11c+ lung DCs by TGF‐β in experimental PF.
Four‐year comparative effectiveness of bare‐metal and everolimus‐eluting stents in New York
Authors: Qian Feng , Zhong Ye , Hannan Edward L. 
Published: May 2017

AbstractObjectivesTo study four‐year outcomes for patients receiving either bare‐metal stents (BMS) or everolimus‐eluting stents (EES) and to evaluate the comparative effectiveness of BMS versus EES in six “off‐label” and two “high‐risk” patient subgroups.BackgroundBMS and EES (a second generation of drug‐eluting stent) are used in contemporary practice to treat coronary artery disease. However, little is known about long‐term comparative effectiveness between BMS and EES.MethodsUsing the New York State (NYS) cardiac registries, statewide hospital discharge data, the National Death Index, and the U.S. Census file, we assessed four‐year outcomes of BMS versus EES in patients receiving either BMS or EES from July 2008 through December 2009. The outcomes included all‐cause mortality, acute myocardial infarction (AMI), target‐lesion PCI (TLPCI), and target‐vessel coronary artery bypass graft (TVCABG) surgery for a follow‐up period of four years (median follow‐up of 3.6 years). We compared 9,290 propensity score matched pairs with further adjustment using Cox proportional hazards regression.ResultsCompared with patients receiving BMS, patients receiving EES had a lower rate of four‐year mortality (adjusted hazard ratio <AHR>: 0.58, 95% confidence interval <CI>: 0.54–0.63), AMI (AHR: 0.68, 95% CI: 0.61–0.76), TLPCI (AHR: 0.67, 95% CI: 0.60–0.75), and TVCABG (AHR, 0.53, 95% CI: 0.43–0.65). For “off‐label” and “high‐risk” subgroups, EES was associated with decreased mortality and generally better AMI, TLPCI, and TVCABG outcomes relative to BMS.ConclusionsCompared with BMS use, EES use was associated with better four‐year outcomes.
Practical Aerobic Oxidation of Alcohols: A Ligand‐Enhanced 2,2,6,6‐Tetramethylpiperidine‐1‐oxy/Manganese Nitrate Catalyst System
Authors: Lagerblom Kalle , Lagerspets Emi , Keskiväli Juha , Cook Chris , Ekholm Filip , Parviainen Arno , Repo Timo 
Published: May 2017

AbstractA highly efficient, ligand‐enhanced 2,2,6,6‐tetramethylpiperidine‐1‐oxy (TEMPO)/Mn(NO3)2 catalyst system for the aerobic oxidation of alcohols is described. From the series of coordinating ligands studied herein, 2‐picolinic acid (PyCOOH) improves the catalytic activity of TEMPO/Mn(NO3)2 remarkably. Under ambient air at room temperature in acetic acid, the ligand‐enhanced catalyst converts aliphatic and benzylic primary alcohols that bear various functional groups into their respective aldehydes with near quantitative conversions. The applicability of the catalyst for convenient preparative synthesis was demonstrated by conducting oxidations on a gram scale. A change of TEMPO to the sterically less demanding 9‐azabicyclo[3.3.1]nonane N‐oxyl results in a Mn catalyst that is also able to oxidize secondary alcohols to ketones. Mechanistic studies showed that alcohols are oxidized by the oxoammonium cation derived from the nitroxyl radical. The active oxidant is regenerated by Mn(NO3)2, and this process is greatly promoted by the coordination of PyCOOH to Mn.
Effect of Acetonitrile‐Based Crystallization Conditions on the Crystal Quality of Vitamin D3
Authors: Gruber-Woelfler Heidrun , Escribà-Gelonch Marc , Noël Timothy , Maier Manuel C. , Hessel Volker 
Published: May 2017

AbstractTo design an integrated continuous crystallization setup that is directly coupled to a photochemical synthesis in flow, the crystallization of vitamin D3 was studied in detail. Because of the high solubility of the vitamin in the reaction solvent tert‐butylmethyl ether, a solvent swap to acetonitrile was necessary. While other methods use a multistep procedure, with the proposed approach, crystalline vitamin D3 can be obtained within one crystallization step. The influence of crystallization parameters, such as the initial concentration of vitamin D3, stirring as well as cooling temperature, rate, and time, on the obtained results in terms of yield, crystal shape, polymorphism, and particle size distribution are discussed in detail.
Synthesis and Characterization of Bromoaluminate Ionic Liquids
Authors: Hog Michael , Schneider Marius , Krossing Ingo 
Published: May 2017

AbstractTwelve bromoaluminate based ionic liquids (ILs) were synthesized and characterized by IR, Raman, and NMR spectroscopy, as well as single crystal X‐ray diffraction in part. Their principal physicochemical properties including melting points, conductivities, viscosities, and densities were determined and compared with related ILs. The influence of the cation and anion on the physicochemical properties are discussed. The [AlBr4]−based salts are—with one exception—solid at room temperature, while the compounds based on the anion [Al2Br7]− are liquid at room temperature. The liquid salts show low viscosities (49–139 mPa s), medium to high conductivities (0.76–3.53 mS cm−1) and high densities (1.82–2.04 g cm−3) at 28 °C. Furthermore, we showed aluminum electrodeposition from Lewis acidic ILs based on AlBr3 and 1‐hexyl‐3‐methylimidazolium bromide and investigated the stability range of various formulations.
Wigner active and passive rotation matrices applied toNMRtensor
Authors: Man Pascal P. 
Published: May 2017

AbstractNMR Hamiltonians are double contraction of two spherical rank‐2 tensors, their space parts are represented by a spherical tensor and their spin parts are composed of spherical tensor operators. The comprehension of modern NMR experiments is very often based on the rotation of these tensors. We present the active and passive rotations in a progressive way from position vector to spherical tensor operator via space function, spherical harmonic, and vector operator. The passive rotation of a physical quantity is described by the rotation of coordinate system. Both the left‐ and right‐handed rotation conventions are applied whereas the right‐handed rotation convention is mainly used in the literature. Throughout the article, we explore the equivalence between the active rotation of a physical quantity in one direction and the rotation of the coordinate system in the opposite direction. The article presents redundant mathematical demonstrations between active and passive rotations, but they clarify the meanings of some important expressions not well developed in the literature.
A numerical investigation and experimental verification of size effects in loaded bovine cortical bone
Authors: Frame J. C. , Wheel M. A. , Riches P. E. 
Published: May 2017

AbstractIn this paper, we present 2‐ and 3‐dimensional finite element–based numerical models of loaded bovine cortical bone that explicitly incorporate the dominant microstructural feature: the vascular channel or Haversian canal system. The finite element models along with the representation of the microstructure within them are relatively simple: 2‐dimensional models, consisting of a structured mesh of linear elastic planar elements punctuated by a periodic distribution of circular voids, are used to represent beam samples of cortical bone in which the channels are orientated perpendicular to the sample major axis, while 3‐dimensional models, using a corresponding mesh of equivalent solid elements, represent those samples in which the canals are aligned with the axis. However, these models are exploited in an entirely novel approach involving the representation of material samples of different sizes and surface morphology. The numerical results obtained for the virtual material samples when loaded in bending indicate that they exhibit size effects not forecast by either classical (Cauchy) or more generalized elasticity theories. However, these effects are qualitatively consistent with those that we observed in a series of carefully conducted experiments involving the flexural testing of bone samples of different sizes. Encouraged by this qualitative agreement, we have identified appropriate model parameters, primarily void volume fraction but also void separation and matrix modulus by matching the computed size effects to those we observed experimentally. Interestingly, the parameter choices that provide the most suitable match of these effects broadly concur with those we actually observed in cortical bone.
Does Confinement Always Lead to Thermodynamically and/or Kinetically Favorable Reactions? A Case Study using Diels–Alder Reactions within ExBox+4and CB[7]
Authors: Chakraborty Debdutta , Das Ranjita , Chattaraj Pratim Kumar 
Published: May 2017

AbstractThe impact of geometrical confinement on the thermodynamic as well as kinetic aspects of a model cycloaddition reaction between 1,3‐butadiene and ethylene have been investigated based on density functional theory calculations. To this end, organic hosts ExBox+4and cucurbit[7]uril (CB[7]) were used to impose confinement effects on the reactants, transition state (TS), and product involved in the reaction. The results suggest that the shape of the host and thereby the nature of the confining regime dictates the thermodynamic outcome of the reaction. The reaction becomes thermodynamically more spontaneous inside CB[7] as compared with that in either ExBox+4or in the “unconfined” gaseous state. Furthermore, the rate constant associated with the reaction increases manifold inside CB[7]. Atoms‐in a‐molecule, noncovalent interaction, natural bond orbital, as well as energy decomposition analyses suggest that the close geometrical proximity of the reactants inside CB[7] as well as extra stabilization of the TS in the encapsulated state may dictate the outcome.
Predicting the Solvent Effect on Esterification Kinetics
Authors: Lemberg Max , Sadowski Gabriele 
Published: May 2017

AbstractIt is well known that solvents influence reaction kinetics. The classical concentration‐based kinetic modeling is unable to describe these effects. In this work, the reaction kinetics was studied for the esterifications of acetic acid and propionic acid with ethanol at 303.15 K. It was found that the reactant ratio as well as the applied solvents (acetonitrile, tetrahydrofurane, dimethylformamide) significantly affect the reaction rate. The thermodynamic model PC‐SAFT was applied to account for the interactions between the reacting species and the solvents via activity coefficients. This allowed the identification of solvent‐independent kinetic constants and the prediction of the solvent effect on reaction kinetics in almost quantitative agreement with experimental data. The presented approach shows the importance of taking into account thermodynamic non‐idealities and significantly reduces experimental effort for finding the best solvent candidate for a given target reaction.
Boom–bust economics and vegetation dynamics in a desert city: How strong is the link?
Authors: Ripplinger Julie , Collins Scott L. , York Abigail M. , Franklin Janet 
Published: May 2017

AbstractIn cities, human activities such as supplemental watering and plantings of ornamental species are thought to decouple vegetation diversity from biophysical processes. Consequently, socioeconomics may arguably be one of the most important factors influencing the pattern and dynamics of vegetation in urban ecosystems. Socioeconomic disturbances, like The Great Recession of 2007 to post‐2010, disrupt normal social and economic activity causing changes to the ecology of cities that have yet to be examined. Using the rapidly growing metropolitan area of Phoenix, Arizona, USA, as a case study, we explored the dynamics of residential vegetation diversity from before to after The Great Recession. Our findings linked changing plant community composition and increasing richness with socioeconomics of the housing boom, (from 2000 to 2006) followed by the Great Recession (from 2007 to post‐2010). Specifically, we found that the housing market boom–bust episode acted as a socioeconomic driver of overall plant community composition. However, plant species with annual reproduction strategies were instead linked to the previous winter's precipitation and did not respond to socioeconomic disturbance, a behavior expected in native desert plant communities, but not from constructed and managed urban plant communities. This study demonstrates how disturbances to socioeconomic components of ecosystems can result in changes to plant community diversity and dynamics; though, biophysical drivers remain important to short‐lived annual species regardless. Undertakings that aim to maintain or increase urban biodiversity for ecosystem services and human well‐being need to systematically approach the effects of socioeconomic fluctuations on urban flora. Cross‐site comparisons will be key to developing a broader understanding of these coupled dynamics across older and newer, mesic and arid, and growing and shrinking cities.
A miniaturized sensor for detection of formaldehyde fumes
Authors: Zilberstein Gleb , Zilberstein Roman , Zilberstein Svetlana , Maor Uriel , Baskin Emmanuil , Zhang Shoumo , Righetti Pier Giorgio 
Published: May 2017

AbstractA miniaturized chemical sensor is here described for the analysis of environmental pollutants (VOC: volatile organic chemicals). It is used for remote detection of formaldehyde (FA) fumes in the atmosphere, and is based on the redox reaction between FA and silver nitrate. The sensor is worn as a bracelet and the data acquired are transferred via a Bluetooth channel to a smartphone. A dedicated software transforms the signal from a grey to a color scale. The signal response has been assessed over low (20 to 120 ppb) as well as higher (1–15 ppm range) levels. The sensor has been applied to monitor potential FA fumes of some artwork in the Summer Palace in Beijing and the modifications induced by FA treatment on a precious Stradivarius violin. The performance of this novel sensor is compared with a commercial apparatus widely adopted, namely the Honeywell MultiRAE Lite wireless portable multi‐gas monitor (pumped model).
Semi‐high‐throughput isolation and N‐glycan analysis of human fibrinogen using monolithic supports bearing monoclonal anti‐human fibrinogen antibodies
Authors: Vidic Urška , Trbojević‐Akmačić Irena , Černigoj Urh , Albers Malena , Gašperšič Jernej , Pučić‐Baković Maja , Vidič Jana , Štrancar Aleš , Lauc Gordan 
Published: May 2017

AbstractFibrinogen (FIB) is a secretory glycoprotein synthesized by hepatocytes that has a key role in blood clotting. Its glycosylation has not been studied in detail and little is known about the biological variability of FIB N‐glycosylation, mainly due to the lack of fast, simple, and robust approaches to purify FIB from blood plasma samples. In recent years, customised chromatographic monoliths have been used for a variety of biological applications due to their unique characteristics. Here we describe development and optimisation of monolithic supports bearing monoclonal anti‐human fibrinogen antibodies in a single column as well as in multi‐well plate formats with high FIB specificity and binding capacity for fast immunoaffinity purification of FIB from human blood samples. The developed semi‐high‐throughput workflow has been successfully applied for FIB immunoaffinity isolation and subsequent ultra performance liquid chromatography N‐glycosylation analysis in ten healthy human individuals, demonstrating the potential of monolithic supports in glycomics studies.
A long-term copper exposure in a freshwater ecosystem using lotic mesocosms: Invertebrate community responses
Authors: Joachim Sandrine , Roussel Hélène , Bonzom Jean-Marc , Thybaud Eric , Mebane Christopher A. , Van den Brink Paul , Gauthier Laury 
Published: May 2017

Abstract

A lotic mesocosm study was carried out in 20-m-long channels, under continuous, environmentally realistic concentrations of copper (Cu) in low, medium, and high exposures (nominally 0, 5, 25, and 75 μg L−1; average effective concentrations &lt;0.5, 4, 20, and 57 μg L−1 respectively) for 18 mo. Total abundance, taxa richness, and community structure of zooplankton, macroinvertebrates, and emerging insects were severely affected at Cu treatment levels of 25 and 75 μg L−1. Some taxa were sensitive to Cu, including gastropods such as Lymnaea spp. and Physa sp., crustaceans such as Chydorus sphaericus, Gammarus pulex, and Asellus aquaticus, rotifers such as Mytilina sp. and Trichocerca sp., leeches such as Erpobdella sp., and the emergence of dipteran insects such as Chironomini. Other taxa appeared to be tolerant or favored by indirect effects, as in Chironimidae larvae, the emergence of Orthocladiinae, and the zooplankter Vorticella sp., which increased in the 25 and 75 μg L−1 treatments. After approximately 8 mo of Cu exposure, the macroinvertebrate community in the high treatment was decimated to the point that few organisms could be detected, with moderate effects in the medium treatment, and very slight effects in the low-Cu treatment. Subsequently, most taxa in the high-Cu exposure began a gradual and partial recovery. By the end of the study at 18 mo, macroinvertebrate taxa richness was similar to control richness, although overall abundances remained lower than controls. After 18 mo of copper exposure, a no-observed-effect concentration at the community level for consumers was set at 5 μg L−1 (4 μg L−1 as average effective concentration), and a lowest-observed-effect concentration at 25 μg L−1(20 μg L−1 as average effective concentration). Environ Toxicol Chem 2017;36:2698–2714. © 2017 SETAC
Emergence of MPLW515 mutation in a patient with CALR deletion: Evidence of secondary acquisition of MPL mutation in the CALR clone
Authors: Partouche Nicolas , Conejero Carole , Barathon Quentin , Moroch Julien , Tulliez Michel , Cordonnier Catherine , Giraudier Stephane 
Published: May 2017

AbstractMyeloproliferative neoplasms are characterized by transduction pathway recognized as mutually exclusive molecular abnormalities such as BCR‐ABL translocation, JAK2V617F or JAK2 exon 12 mutations, MPL w515, and CALR mutations. However, in some rare cases, associations of such mutations are found in 1 patient. This can be related to 2 pathologies (at least 2 different clones harboring 2 mutations) or associated mutations in 1 clone. We describe here such an association of CALR and MPL mutations in a patient harboring the second mutation in a subclone during the phenotypic evolution of the myeloproliferative neoplasms.
Recreational stimulants, herbal, and spice cannabis: The core psychobiological processes that underlie their damaging effects
Authors: Parrott Andrew C. , Hayley Amie C. , Downey Luke A. 
Published: May 2017

AbstractAimsRecreational drugs are taken for their positive mood effects, yet their regular usage damages well‐being. The psychobiological mechanisms underlying these damaging effects will be debated.MethodsThe empirical literature on recreational cannabinoids and stimulant drugs is reviewed. A theoretical explanation for how they cause similar types of damage is outlined.ResultsAll psychoactive drugs cause moods and psychological states to fluctuate. The acute mood gains underlie their recreational usage, while the mood deficits on withdrawal explain their addictiveness. Cyclical mood changes are found with every central nervous system stimulant and also occur with cannabis. These mood state changes provide a surface index for more profound psychobiological fluctuations. Homeostatic balance is altered, with repetitive disturbances of the hypothalamic–pituitary–adrenal axis, and disrupted cortisol‐neurohormonal secretions. Hence, these drugs cause increased stress, disturbed sleep, neurocognitive impairments, altered brain activity, and psychiatric vulnerability. Equivalent deficits occur with novel psychoactive stimulants such as mephedrone and artificial “spice” cannabinoids. These psychobiological fluctuations underlie drug dependency and make cessation difficult. Psychobiological stability and homeostatic balance are optimally restored by quitting psychoactive drugs.ConclusionsRecreational stimulants such as cocaine or MDMA (3.4‐methylenedioxymethamphetamine) and sedative drugs such as cannabis damage human homeostasis and well‐being through similar core psychobiological mechanisms.
But What Does It Look Like? Illustrations of Disciplinary Literacy Teaching in Two Content Areas
Authors: Rainey Emily C. , Maher Bridget L. , Coupland David , Franchi Rod , Moje Elizabeth Birr 
Published: May 2017

AbstractIn this piece, the authors offer two illustrations of central features of disciplinary literacy teaching. One illustration describes an episode of history literacy teaching, and the other describes an episode of physics literacy teaching. Both examples show how teachers may support students’ development of disciplinary inquiry, disciplinary concepts, and extended use of texts in secondary classrooms. Illustrations were drawn from a long‐term study of the teaching practice of attending teachers and preservice teaching interns affiliated with Clinical Rounds, the secondary undergraduate teacher education program at the University of Michigan. Conclusions are relevant for teachers seeking to design and enact disciplinary literacy teaching in their classrooms and for all literacy practitioners seeking a common language for recognizing and naming aspects of disciplinary literacy teaching across disciplinary domains.