bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASPECTS FROM THE BIOGRAPHY OF PROFESSOR CORNEL TIBERIU OPRIŞ. THE BEGINNINGS
Authors: Rotaru Alexandru 
Published: October 2016

Professor Cornel Tiberiu Opriş was the founder of the clinic for Oral and Maxillofacial Surgery, and also the first to teach this specialty in Cluj-Napoca in the first half of the twentieth century.Earlier in his profession, Dr. Cornel Opriş went from research into human physiology to practical activity in the field of surgery, to which he was more attracted.He was active both in research and Oral and Maxillofacial plastic surgery, facing unfavorable material and social conditions, exacerbated by the circumstances of war and the relocation of the Faculty of Medicine to Sibiu. This article presents the life and work of Prof. Dr. Cornel Opris, with particular reference to the stage of education, the problems associated with "family, society and school."
Phase II and Biomarker Study of Cabozantinib in Metastatic Triple-Negative Breast Cancer Patients
Authors: Tolaney Sara M. , Ziehr David R. , Guo Hao , Ng Mei R. , Barry William T. , Higgins Michaela J. , Isakoff Steven J. , Brock Jane E. , Ivanova Elena V. , Paweletz Cloud P. , Demeo Michelle K. , Ramaiya Nikhil H. , Overmoyer Beth A. , Jain Rakesh K. , Winer Eric P. , Duda Dan G. 
Published: October 2016

AbstractCurrently, no targeted therapies are available for metastatic triplenegative breast cancer (mTNBC). We evaluated the safety, efficacy, and biomarkers of response to cabozantinib, a multikinase inhibitor, in patients with mTNBC. We conducted a single arm phase II and biomarker study that enrolled patients with measurable mTNBC. Patients received cabozantinib (60 mg daily) on a 3-week cycle and were restaged after 6 weeks and then every 9 weeks. The primary endpoint was objective response rate. Predefined secondary endpoints included progression-free survival (PFS), toxicity, and tissue and blood circulating cell and protein biomarkers. Of 35 patients who initiated protocol therapy, 3 (9% [95% confidence interval (CI): 2, 26]) achieved a partial response (PR). Nine patients achieved stable disease (SD) for at least 15 weeks, and thus the clinical benefit rate (PR+SD) was 34% [95% CI: 19, 52]. Median PFS was 2.0 months [95% CI: 1.3, 3.3]. The most common toxicities were fatigue, diarrhea, mucositis, and palmar-plantar erythrodysesthesia. There were no grade 4 toxicities, but 12 patients (34%) required dose reduction. Two patients had TNBCs with MET amplification. During cabozantinib therapy, there were significant and durable increases in plasma placental growth factor, vascular endothelial growth factor (VEGF), VEGF-D, stromal cell-derived factor 1a, and carbonic anhydrase IX, and circulating CD3 + cells and CD8 + T lymphocytes, and decreases in plasma soluble VEGF receptor 2 and CD14+ monocytes (all p &lt; .05). Higher baseline concentrations of soluble MET (sMET) associated with longer PFS (p = .03). In conclusion, cabozantinib showed encouraging safety and efficacy signals but did not meet the primary endpoint in pretreated mTNBC. Exploratory analyses of circulating biomarkers showed that cabozantinib induces systemic changes consistent with activation of the immune system and antiangiogenic activity, and that sMET should be further evaluated a potential biomarker of response.
ABORDAJE DE LA COMUNICACIÓN EN UN CASO DE ALZHEIMER DE VARIANTE LINGÜÍSTICA
Authors: Pérez Lancho Maria Cruz , Hernández Sánchez Raquel 
Published: October 2016

Abstract.This work aims to show how language deterioration can be addressed in Alzheimer’s disease. Taking into account that the cognitive intervention is programmed in a context of progressive loss of memory, agnosia, apraxia and executive deficit, the approach can’t be analogous to that of aphasia acquired by focal brain injury. Therefore, it’s necessary to make an assessment of the aphasic profile at each stage of the disease in order to create the most appropriate intervention, while patient’s relatives are informed about the communication difficulties that appear and which become gradually more complicated and how to deal with them. It presents a case of Alzheimer - type dementia, with early onset communication difficulties, treated in the healthcare service of the Pontificia University of Salamanca. The evaluation of cognitive and functional impairment, the detailed study of language deficits, the approach of individualized therapy and intervention guidelines to improve communication interactions with the caregiver in the family are described in this work.Keywords: Alzheimer, language, evaluation, treatment, caregiver.Resumen.El presente trabajo pretende mostrar cómo puede abordarse el deterioro del lenguaje en la enfermedad de Alzheimer. Teniendo en cuenta que la intervención cognitiva se programa en un contexto de pérdida de memoria, apraxia, agnosia y déficit ejecutivo, el abordaje no puede ser análogo al de las afasias adquiridas por lesión cerebral focal. Por tanto, es preciso realizar una valoración del perfil afásico en cada etapa de la enfermedad para diseñar la intervención que resulte más apropiada, a la vez que se informa a los familiares de las dificultades para la comunicación que van apareciendo de forma paulatina y cómo afrontarlos. Se presenta un caso de demencia tipo Alzheimer, con dificultades comunicativas de aparición precoz atendido en el Servicio Asistencial de la Universidad Pontificia de Salamanca. Se describe el proceso de evaluación del deterioro cognitivo y funcional, el estudios pormenorizado de los déficits de lenguaje, el planteamiento de la intervención individualizada y las pautas para mejorar la interacción comunicativa con el cuidador, en el entorno familiar.Palabras clave: Alzheimer, lenguaje, evaluación, tratamiento, cuidador
INTERACCIÓN DE LOS MAYORES EN EL ÁMBITO DE LA SEGURIDAD LOCAL
Authors: Martín Mederos Carmen Delia , Rodríguez Arteaga Rosa María 
Published: October 2016

Abstract.Throughout the latest years it has been seen how Police Organizations are undergoing a continued transformation in the structure and internal organization with the forecast marked by the achieving objectives that have been marked by the politics direction. Today society is marked by the globalization effect which requires more adaptable and malleable Police Organizations where the internal changes happen with rapidity and closeness demanded. This social transformation process has acquired a prominent importance in Police-Citizen social interaction to reach proactivity’s efficacy in police conduct. The citizen is the main security’s focus and Local Polices are the main resource to guarantee local security. In local sphere stands out the increasing importance of Local Police department in Comunity’s social relationships in order to reduce the insecurity’s citizen perception, the biggest challenge society is facing in welfare state.Keywords: local police, social relations, profesiosional performance, SecurityResumen.A lo largo de estos últimos años se ha visto como las organizaciones policiales están sufriendo una transformación constante en su estructura y organización interna con el horizonte marcado en lograr la disminución en la percepción de la inseguridad ciudadana. En la actualidad, la sociedad marcada por el efecto globalización exige organizaciones policiales más flexibles y moldeables, donde los cambios internos en la misma se sucedan con la rapidez e inmediatez necesaria que la sociedad demande. En ese proceso de transformación social han adquirido notable importancia las interacciones sociales entre Policía-ciudadano a fin de lograr la efectividad de la proactividad en las actuaciones policiales. El ciudadano es el principal protagonista de la seguridad y las Policías locales en el ámbito de la seguridad local son el principal instrumento para garantizarla. Palabras clave: Policía local, Interacción social, desempeño, Seguridad.
EL BUEN USO DE LA RAZÓN DEPENDE DE LAS EMOCIONES
Authors: Requena Hernández Carmen , Álvarez Merino Paula , Salto Alemany Francisco 
Published: October 2016

Abstract.Getting to know the capacities and limitations of the reasoning brain can help us to understand why some learning situations are efficient while others are not. Brain imaging techniques can offer this information, hence current neuroscience is inclined to use service-learning methodologies which include emotion when measuring mental and brain learning efficiency. In this paper we collect results from empirical research on logico-emotional training based in control by inhibition strategies. This strategy consists in training subjects in self-instructions to avoid falling into the perceptive pairing bias. Results show an increase in the percentage of success from 10% to 90% of the trained subjects, as opposed to subjects trained with other methodologies commonly used in the classroom. As a conclusion, it has been shown that brain activity hints of metacognition imply a deeper and more successful learning experience in the teacher/pupil diad.Key words: Social competence, Young, Older persons, Computer technology, Social abilitiesResumen.Conocer las capacidades y limitaciones del cerebro que razona puede ayudarnos a entender por qué algunas situaciones de aprendizaje son eficaces y otras o no. Las imágenes cerebrales proporcionan esta información de modo que la neurociencia actual se inclina por metodologías de enseñanza-aprendizaje que incluyen la emoción al apreciar su eficacia a nivel mental y cerebral. En este artículo se recogen los resultados de investigaciones apoyadas en el entrenamiento logicoemocional fundamentado en la estrategia control por inhibición. Esta estrategia consiste en entrenar al sujeto en autoinstrucciones para impedir que caiga en la trampa de sesgo de emparejamiento perceptivo. Los resultados muestran un aumento de porcentaje de éxito de un 10% a un 90% en los sujetos entrenados en este tipo de práctica, frente a sujetos entrenados con otro tipo de metodologías utilizadas frecuentemente en las escuelas. Conclusión, “sentir la sensación de lo que sucede” conlleva una experiencia de aprendizaje más comprometida y exitosa en la díada maestro/aprendiz.Palabras clave: Control por inhibición, Metacognitivo, Neurociencia, Lógicoemocional.
PENDAMPINGAN PENGOLAHAN PANGAN LOKAL DI DESA KELORAN WONOGIRI
Authors: Yudhistira Bara , Karyanta Nugraha Arif , Triharyanto Eddy 
Published: October 2016

<p>Desa Keloran Kecamatan Selogiri merupakan salah satu kecamatan di Kabupaten Wonogiri. Meskipun hasil singkong di daerah ini tidak sebanyak daerah lain, namun desa ini memiliki potensi yang menjanjikan sebagai penghasil tanaman ubi kayu (singkong). Singkong biasanya hanya ditanam di lahan kebun belakang rumah warga. Hasil panen singkong dari kebun lebih sedikit dan biasanya hanya diolah menjadi gaplek untuk dikonsumsi sendiri, jika peralatan memadai para ibu rumah tangga akan mengolah singkong menjadi keripik dan dikemas seadanya kemudian dijual di pasar atau dititipkan ke warung-warung makan. Metode yang digunakan untuk membantu mengatasi persoalan-persolan dihadapi mitra adalah melalui pelatihan manajemen usaha, pelatihan produksi makanan, pemberian bantuan dukungan alat produksi dan pendampingan.</p>
Analisis Pemasaran Domba dari Tingkat Peternak Sampai Penjual Sate di Kabupaten Sleman
Authors: Suwarta F.X. 
Published: October 2016

<p><em>This aim of this research was to study marketing chain of sheeps from farmer, trader and satay seller and to study cost of marketing at each of instituted marketing and the revenue of farmer, trader and satay seller in Sleman regency, Yogyakarta. The research was conducted using a survey method. The respondents from sheep farmer, sheep trader and satay seller were 107, 37 and 64, respectively. Data were analyzed descriptively. The cost efficiency of marketing system was analyzed for marketing cost, margin, farmer’s share, market competition and profitability. The result showed that the most efficient of the distribution of the sheep marketing was from sheep, farmer, sheep trader and consumer. Margin analyzed showed that male sheep contributed larger margin than female sheep (19.78: 19.14%). The farmer share for sheep marketing revealed that female sheep contributed 80.85% while male sheep 80.21%. Coefficiency of market competition showed that sheep farmer had higher coefficiency competition than sheep trader both to female and male. Sheep farmer had higher net profit margin (NPM) level but had lower operating ratio level. Satay seller had lower NPM and higher operating ratio level.</em></p><p><em> </em></p><p><em>Key words</em><em> : sheep, marketing, efficiency of marketing</em></p>
Isolasi dan Karakterisasi Fitase dari Mikroba yang Terdapat pada Pupuk Kompos, Rumen Sapi, Ragi dan Tanah Sawah
Authors: Sajidan Prof. Dr.rer.nat. 
Published: October 2016

<div class="WordSection1"><p><em> </em></p><p><em> This research was aimed to isolate and characterize phytase from different source</em><em>s</em><em> of higger phosphat complex compound</em><em>s</em><em> (compost, cattle rumen, and yeast). Bacteria of phytase was isolated on Luria Bertani (LB) medium and it was incubated on 37 <sup>o</sup>C for 16 hours. Microbe from yeast was isolated on Pottato Dextrose Agar (PDA) medium. Crude enzyme from supernatant was extracted with centrifuge on 5.000 rpm for 5 minutes. Crude enzyme was characterized for optimum pH, temperature, and influence of matalo ion efector on relative activity of enzyme. B1 isolate from P88 compost had optimum relative activity on pH 5, temperature 50 <sup>o</sup>C and activator Zn<sup>2+</sup> (10<sup>-3</sup> and 10<sup>-4</sup> M). B2 Isolate from cattle rumen had optimum relative activity on pH 5, temperature 50 <sup>o</sup>C and activator Zn<sup>2+</sup> (10<sup>-3</sup> M) and Mg<sup>2+</sup> (10<sup>-4</sup> M). B3 isolated from soy sauce yeast had optimum relative activity on pH 5, temperature 60 <sup>o</sup>C, and activators Mg<sup>2+</sup> (10<sup>-3 </sup>M) and, Fe<sup>2+</sup> (10<sup>-4</sup> M). B4 isolated from tempeh yeast had optimum relative activity on pH 5, temperature 50 <sup>o</sup>C and activators Mg<sup>2+</sup> (10<sup>-3 </sup>M) and Ca<sup>2+</sup> (10<sup>-4</sup> M).</em></p><p><strong><em> </em></strong></p><p><strong><em>Key words</em></strong><em>: phytase, optimum pH, optimum temperature, metalo ion efector, isolate.</em></p></div><strong><br clear="all" /> </strong>
Evaluasi Dedak Padi Kukus dan Suplementasi MHA (Methionine Hidroxy Analog) terhadap Kecernaan Nutrien Ransum Domba Lokal Jantan
Authors: Suprayogi Wara Pratitis Sabar , Widyawati Susi , Hidayah R. 
Published: October 2016

<p><em>The research aimed to know the effect of rice bran steaming and MHA supplementation on the increasing of nutrient digestibility of local male sheep. This research used 12 local male sheeps with average of body weight 10.32 ± 1.02 kg. Treatment of rations were for P0 (60 % king grass + 40 % bran), P1 (60 % king grass +40 % steamed bran), P2 (60 % king grass + 40 % steamed bran + 1 g MHA). Design used in research was Completely Randomized Design (CRD) in one-way pattern using 3 treatments. Each treatment consisted of 4 replications. Parameters observed were dry matter intake, organic matter intake, dry matter nutritive value index and organic matter nutritive value index.</em><em> The result of treatment P0, P1, and P2 for dry matter intake were 960.024; 909.426; and 926.399 g/head/day respectively, organic matter intake were 825.036; 772.665; and 796.225 g/head/day, organic matter digestibility in percent were 72.424; 73.050; and 73.068, organic matter digestibility in percent were 75.989; 76.306; and 76.239, dry matter nutritive value index were 695.396; 664.392; and 677.654 g/head/day and organic matter nutritive value index were 626.894; 589.985; and 607.649 g/head/day.</em><em> The variance Analysis showed that the usage of steamed rice bran and adding of MHA given non significantly effect (P&gt;0.5) on dry matter intake, organic matter intake, dry matter digestibility, organic matter digestibility, dry matter nutritive value index, and organic matter nutritive value index.</em><em> It can be concluded that the treatments did not affect variables that were measured.</em></p><p><em> </em></p><p><em>Keyword : </em><em>local male sheep, steamed bran, MHA, digestibility</em><em></em></p>
Efek Perbedaan Komposisi Konsentrat terhadap Perbaikan Nilai Nutrisi Jerami Padi
Authors: Widyawati Susi Dwi 
Published: October 2016

<p><em>Since rice straw is seasonal and low quality roughage, </em><em>thus, </em><em>a supplementation for it is needed. Lamtoro lea</em><em>f</em><em> meal (LLM) and soybean meal (SBM), hav</em><em>e</em><em> both soluble and bypass protein</em><em>, </em><em>so it enough potential to supply nutrients </em><em>to</em><em> optimize of rumen microbes and improv</em><em>e </em><em>animal performance. Supplementation with LLM or SBM significantly increase</em><em>d</em><em> dry matter, organic matter, crude protein and crude fiber intake (</em><em>P</em><em>&lt;0.05). This fact showed that LLM or SBM supplementation made an </em><em>improvement</em><em> of rumen fermentation by microbes. Comparison between LLM and SBM to basal diet clearly showed that basal diet </em><em>wa</em><em>s the lowest (</em><em>P</em><em>&lt;0.0</em><em>5</em><em>) nutrien</em><em>t</em><em> intake and nutrien</em><em>t</em><em> digestibility, however, the animal fed basal diet degraded crude fiber was not </em><em>affected</em><em>. It </em><em>has been shown that</em><em> sup</em><em>p</em><em>lementation with lamtoro lea</em><em>f</em><em> meal or soybean meal </em><em>we</em><em>re palatable, fermentable and reasonably digestible. </em><em>Therefore, the</em><em> use</em><em> of these feedstuffs</em><em> as supplement to rice straw </em><em>are</em><em> strongly recommended. </em></p><p><em> </em></p><p><strong><em>Key words</em></strong><em> : </em><em>concentrate</em><em>, PO beef cattle, </em><em>performance, </em><em>digestibility</em></p>
Strategi Pengembangan Usaha Peternakan Sapi Perah Rakyat di Kabupaten Boyolali
Authors: Barokah U. 
Published: October 2016

<p><em>The ai</em><em>m of this research </em><em>was to study development strategy of effort ranch dairy cattle farmer. Basic method used in this research </em><em>was descriptive. Determination of research area </em><em>was purposive </em><em>that was Boyolali Regency with subdistrict Musuk</em><em>, and than taken one village is Sukorejo. Farmer taken as sample in this research are farmer have adult dairy cattle. </em><em>The respondent</em><em>s </em><em>were tahken by simple random sampling </em><em>resulting 40 dairy cattle farmer</em><em>s. Development strategy of ranch of dairy cattle farmer implementation with improving management by a). improving business scale from farmer by exploiting governmental role, KUD, BRI by exploiting given programs, b) combining the feed so that get standard minimum cost </em><em>and obtained quantity and quality fresh milk, c) doing the pure </em><em>artificial insemination or embryo transfer from dairy cattle FH. </em></p><p><em> </em></p><p><strong><em>Key words :</em></strong><em> </em><em>Development strategy, </em><em>animal agriculture, dairy cattle</em></p>
Remaining Saturations of Supercritical CO2 in Mixed-wet Carbonates for Carbon Utilization in Oil Fields: Core to Pore Scales Observations and Field Scale Implications
Authors: Al-Menhali Ali , Krevor Samuel , Carbonates Qatar 
Published: October 2016

Abstract
Capillary trapping has been identified as a key storage process that leads to the immobilisation of CO2 as a non-wetting droplets surrounded by brine in the water-wet porous rocks of saline aquifers limiting the extent of CO2 plume migration and enhancing the storage security. On the other hand, CO2 injection into commercial oil fields have several advantages and account for the majority of the current portfolio of CO2 storage sites and likely to remain the dominate storage options for the initial phase storage projects. Oil fields are well characterized and have the infrastructure that can be repurposed for CO2 injection for enhanced oil recovery (EOR) and carbon storage. In contrast, oil reservoirs, most of which in carbonate rocks, are characterised by a mixed-wet state in which the capillary trapping of nonpolar fluids have been observed to be significantly reduced relative to trapping in water-wet rocks typical of saline aquifers unaltered by the presence of hydrocarbons. There are, however, no observations characterising the extent of capillary trapping that will take place with CO2 in mixed-wet rocks. We use X-ray computed tomography (CT) at the core scale and microtomography (μCT), at high voxel resolutions upto 2 ^m, to investigate the pore-scale arrangement of supercritical CO2 droplets and measure the contact angles in situ comparing water-wet and mixed-wet carbonates at temperatures and pressures representative of subsurface oil reservoirs and saline aquifers. The measurements were made while maintaining chemical equilibrium between the fluids (CO2 and brine) and rock phases to prevent reaction with the core sample and replicate conditions far away from the injection site. Initial-residual (IR) CO2 characteristic curves were measured first on the sample at original water-wet state, then were measured again after altering the wetting properties to a mixed-wet system. In particular, CO2 trapping was characterized before and after wetting alteration so that the impact of the wetting state of the rock is directly observed. The measurements were also compared with trapping of N2. Here we show that residual CO2 trapping of supercritical CO2 in a limestone altered to a mixed-wet state with oil is significantly less than trapping in water-wet systems characteristic of saline aquifers. We anticipate this work to highlight a controversial issue for the early deployment of carbon storage - that those sites which are economically most appealing as initial project opportunities are the very locations in which the contribution of capillary trapping to storage security will be minimised. This should serve as a starting point for modelling studies to incorporate the reduced impact of capillary trapping on CO2 injection projects using hydrocarbon reservoirs.
Barite Sag and Its Impact On Annular Pressure Build Up Mitigation In Producing Offshore Wells
Authors: Calçada L. A. , Scheid C. M. , Meleiro L. A. , Ribeiro J. M. , Seufitelli G. V. , Peliano S. V. , Santos H.F.L. , Souza E. A. , Monteiro V. , Martins A. L. 
Published: October 2016

Abstract
Among several possibilities for APB mitigation, the strategy of communicating the annulus with a formation is often considered. In this case, when pressure reaches formation fracture, fluid would be drained from the annulus and thus, the pressure would be released. This article presents a comprehensive methodology to tackle the ability of the drilling fluid to relieve pressure when this mitigation strategy is chosen. The model consists on the following iterative steps: Prediction of the solids sedimentation along the time, comprising the formation of three segregation zones; Prediction of the evolution of the permeability of the decanted layer; Prediction of the pressure evolution inside the annulus, based on PVT expressions experimentally obtained for compressible organic based drilling fluids; and Calculation of the draining process which governs pressure relief. The final package is a casing design tool which enables cost well integrity reliability.