bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polypharmacy
Authors: Kocurek Barbara 
Published: October 2024

Preview
Many patients with diabetes will be on multiple medications and experience polypharmacy. Medications are considered the standard of medical care for diabetes and its related complications and it is not uncommon for patients to take five or more medications (Table 25.1). Since the use of multiple medications is likely unavoidable, the goal is to use the most appropriate medications to achieve control with minimal adverse effects, which would be appropriate polypharmacy. Taking too many medications that cause harm, called inappropriate polypharmacy, is more common in patients with multiple prescribers, complex drug regimens, increased age, psychosocial factors, and adverse drug reactions that are interpreted as new medical conditions.
Cystic Fibrosis–Related Diabetes
Authors: Spollett Geralyn , Brunzell Carol 
Published: October 2024

Preview
Cystic fibrosis (CF), one of the most common lethal genetic diseases in Caucasians, affects &gt;30,000 children and adults in the U.S., with 1,000 children diagnosed each year. It is a progressive disease causing lung infections with limited ability to breathe over time. The disease has no cure, but with advances in research and treatment, people with CF are living longer. The median predicted survival for people with CF has increased by 8 years since 2002, from 31.3 years in 2002 to 39.3 years in 2014; however, many people live into their sixth and seventh decades. With the increase in survival, the number of patients with CF-related diabetes (CFRD) also has risen, becoming a leading comorbidity in this group. CFRD occurs in ∼20% of adolescents and 40–50% of adults, but it can occur at any age and is associated with worse survival. Impaired glucose tolerance (IGT) occurs in up to 75% of adults with CF.
CFRD is a distinct clinical entity. It shares components of both type 1 diabetes (T1D) and type 2 diabetes (T2D). It differs, however, from both T1D and T2D in that it is characterized by insulinopenia, but periods of insulin resistance also occur as a result of stress, pregnancy, illness, and use of steroids for pulmonary exacerbations. Ketoacidosis is extremely rare because of residual endogenous insulin secretion. As with T2D, the onset is often insidious and can exist for 2–4 years before diagnosis. The initial deficiency is an impaired first-phase insulin response; as patients age, peak insulin response is delayed and less robust than normal.
Pemenuhan Hak Warga Negara Untuk Menyampaikan Pendapat dalam Memperkuat Digital Citizenship Melalui Sambat Online Pemerintah Kota Malang
Authors: Saputra Nugroho Dwi , Saputra Meidi 
Published: October 2024

AbstractThis research aims to describe citizen participation in submitting complaints via Complain Online, a strategy to fulfill citizens' rights in digital citizenship, and the obstacles faced in fulfilling these rights. The method used is qualitative with a descriptive approach, collecting data through interviews, observation and documentation. The validity of the data was tested by triangulation and analysis using an interactive analysis model. The results of this research show that community participation through Complain Online increasing in quantity, but there is still a lack of responsibility in the use of digital media. The government needs to invest in efforts to improve the community's ability to express opinions as well as resources to develop ways to strengthen its realization digital citizenship. This can be done by developing a strategy to fulfill the right to opinion, including providing it website, socialization, electronic forms and platform development. In order for this strategy to be effective, the public must be given adequate understanding and provision regarding their responsibilities in utilizing these facilities. Also, efforts need to be made to overcome internal obstacles including rapid turnover of ASN and lack of technological skills and external obstacles including budget limitations and the cessation of socialization. --------------------------------Abstrak Penelitian ini bertujuan mendeskripsikan partisipasi warga dalam menyampaikan aduan melalui Sambat Online, strategi pemenuhan hak warga dalam digital citizenship, dan hambatan yang dihadapi dalam pemenuhan hak tersebut. Metode yang digunakan adalah kualitatif dengan pendekatan deskriptif, mengumpulkan data melalui wawancara, observasi, dan dokumentasi. Validitas data diuji dengan triangulasi dan analisis menggunakan model analisis interaktif. Hasil penelitian ini menunjukkan bahwa partisipasi masyarakat melalui Sambat Online meningkat secara kuantitas, namun masih ada kurangnya tanggung jawab dalam penggunaan media digital. Pemerintah perlu berinvestasi dalam upaya meningkatkan kemampuan masyarakat dalam berpendapat serta sumber daya untuk mengembangkan cara-cara untuk memperkuat terwujudnya digital citizenship. Hal ini, dapat dilakukan dengan menyusun strategi pemenuhan hak berpendapat mencakup penyediaan website, sosialisasi, formulir elektronik dan pengembangan platform, Agar strategi ini dapat berjalan efektif, masyarakat harus diberikan pemahaman dan pembekalan yang memadai terkait tanggung jawab mereka dalam memanfaatkan fasilitas tersebut. Serta, perlu adanya upaya mengatasi hambatan internal termasuk pergantian ASN yang cepat dan kurangnya keterampilan teknologi dan hambatan eksternal meliputi keterbatasan anggaran dan terhentinya sosialisasi.
HCI y nuevas interfases aplicadas a bioperformances interactivas en prácticas corporales de inclusión
Authors: Ceriani Alejandra Cristina 
Published: October 2024

El presente texto recoge prácticas tecnológicas que se proponen favorecer la comprensión del uso de instrumentación biomédica orientada hacia ​sistemas vestibles, es decir, dispositivos que pueden instalarse con facilidad en distintas partes del cuerpo con el fin de capturar los datos de las señales bioeléctricas del cuerpo y así, proponer, nuevas trayectorias a los procesos de percepción de lo corporal. En consecuencia, identificar, estudiar y sistematizar el conocimiento que performers, ingenieros y programadores desarrollan en proyectos de inclusión expresiva; nos permitirá construir un marco conceptual sobre esta práctica artística transdisciplinar, su potencial expresivo para la atención a la diversidad. Entendemos que, es importante que la comunidad educativa, tome conocimiento de estas prácticas artísticas, se extienda su aplicación y uso progresivo, con el fin de mejorar la calidad de la enseñanza-aprendizaje para el área que tiene como objetivo fundamental a la corporalidad. Se trata de una contribución técnico-expresiva, que pretende destacarse como una propuesta innovadora, de la misma forma, promover reflexiones sobre las concepciones de Educación, Arte y Tecnología Inclusiva. Una recopilación de experiencias basadas en las TIC en entornos educativos realizadas con personas con discapacidad, recogen las pautas para la creación de recursos educativos digitales accesibles y las herramientas necesarias para su aplicación. En el proceso educativo, la representación de un entorno digital como base para la observación y el estudio, es una oportunidad metodológica y epistémica, donde el planteamiento de un caso es siempre una oportunidad de aprendizaje significativo y trascendente en la medida en que quienes participan en su análisis logran involucrarse y comprometerse tanto en la exploración como en el proceso grupal para su ejecución. Basado en la anterior ilación se presenta a continuación prácticas relacionadas con la inclusión tecnológica y la accesibilidad educativa con el propósito de garantizar la igualdad de condiciones a todas las personas con o sin discapacidad.
Notas sobre los cuerpos educados en la revista El Monitor de la Educación Común
Authors: Fittipaldi Gerardo Javier 
Published: October 2024

La revista El Monitor de la Educación Común, publicación oficial del Consejo Nacional de Educación, fue una de las revistas más importantes del campo pedagógico y educativo argentino que llegaba mensualmente a una gran cantidad de escuelas y colegios del país. En dicha publicación es posible rastrear debates y acontecimientos fundamentales que marcaron la historia de la educación física. En ese trabajo nos ocupamos de aquello que pudo significar la educación de los cuerpos, buscando dilucidar la categoría de cuerpo educado en la primera década del siglo XX.
Implementasi analisis sentimen pada ulasan aplikasi Duolingo di Google Playstore menggunakan algoritma Naïve Bayes
Authors: Apriliyani Meli , Musyaffaq Mirza Izzal , Nur’Aini Siti , Handayani Maya Rini , Umam Khotibul 
Published: October 2024

Penelitian ini menyelidiki analisis sentimen evaluasi Aplikasi Duolingo menggunakan metode Naive Bayes. Program Duolingo mencontohkan penggunaan teknologi data besar untuk pemrosesan data yang luas dan rumit. Google Play Store menawarkan fungsi peninjauan dan pemeringkatan yang dapat membantu pengembangan program dan perbaikan aspek yang tidak diinginkan. Proyek ini menggunakan teknik analisis sentimen yang secara otomatis menganalisis ulasan produk internet Indonesia dan mendapatkan informasi mengenai perasaan yang diungkapkan dalam ulasan tersebut. Metode Naïve Bayes digunakan untuk menentukan klasifikasi ulasan menjadi positif atau negatif. Temuan penelitian menunjukkan bahwa kumpulan data yang terdiri dari 1000 data yang berasal dari ulasan program Duolingo di Google Play Store diberi label secara manual sebelum ke langkah prapemrosesan. Dari jumlah tersebut, 500 data memiliki sentimen positif, sedangkan 500 data memiliki sikap negatif. Selain itu, analisis sentimen menunjukkan tingkat akurasi sebesar 86%. Skor f1 menunjukkan nilai presisi 89% dan recall 83%, dengan hasil f1 pada klasifikasi sebesar 86%.
Accuracy of oscillometric blood pressure measurement using a Cardell Touch multiparameter monitor in anesthetized pigs
Authors: Zeitouneh Stephanie , Araos Joaquin , Martin-Flores Manuel 
Published: October 2024

Abstract

OBJECTIVE
To assess the accuracy of an oscillometric monitor in anesthetized pigs and its ability to track changes in mean arterial pressure (MAP) and to detect arterial hypotension and hypertension in reference to direct measurements.

METHODS
Mean arterial pressure was measured simultaneously from a catheter in a femoral artery and with an oscillometric cuff placed over the metatarsus in 9 anesthetized pigs (∼6 months old, 35 to 55 kg). Pigs were subjected to maneuvers to alter MAP. Paired values for invasive and noninvasive MAP (iMAP and NiMAP) were recorded every 2 minutes. Bland-Altman plots with bias, limits of agreement, and percentage error were constructed using each pair and the average of 5 consecutive values. Concordance was calculated using changes in MAP at 20-minute intervals. Receiver operating characteristics (ROC) curves were constructed to test NiMAP for detection of hypotension (< 70 mm Hg) and hypertension (≥ 120 mm Hg).

RESULTS
Bias of NiMAP was −8.59 mm Hg for consecutive pairs and −8.85 mm Hg for averaged pairs, relative to iMAP. Limits of agreement and percentage error were reduced for averages (19%) over individual pairs (26%). Concordance was 82%. The area under the ROC curve for detecting hypotension with NiMAP was 0.936, with a best cutoff value of 63 mm Hg NiMAP. The area under the ROC curve for hypertension was 0.940, with a best cutoff value of 101 mm Hg NiMAP.

CONCLUSIONS
Averaging several consecutive values improves the accuracy of NiMAP measurements.

CLINICAL RELEVANCE
This device correctly tracked changes in MAP approximately 80% of the time and appears reliable for diagnosing arterial hypotension.
Caries Risk Assessment in Adults with Highlights to Nutrigenomics and Nutrigenetics
Authors: Boteva E. S. , Yantcheva S. M. , Karayasheva D. P. 
Published: October 2024

Abstract
Caries risk assessment and caries management by risk assessment cannot be related only to children and their parents' answers. Camra and Cariogram have been working for decades in few countries. Prediction and preventive measures are especially important for young adults (16-25 years old), young professionals (25-35 years old), before pregnancy and during menopause.

Aim
To develop a card for an easy caries risk assessment with chair-aside questions, clinical examination and salivary tests. To draw up a protocol for patient treatment and follow-up related to the caries risk.

Methodology
It is based on the data of 1,167 participants in 6 different clinical studies conducted within various research trials, granted programmes and projects during the 30-year period from 1988 to 2018. Prediction of risk can be useful if 4 groups, i.e. low risk, moderate risk, high risk and very high risk groups are evaluated.

Results
Packages of measures were targeted for each group. Among the important factors were the type, habits and frequency of nutrition, detected with 6 targeted questions, lifestyle hygiene with 5 questions, dental status with 6 parameters (DMFT scores, gingival status, size of teeth, etc.) and oral hygiene. Biochemical patterns of saliva, i.e. salivary flow rate and pH, with and without stimulation were included. Low risk and Moderate risk groups of different ages do not need further tests. High risk and Very high risk groups can be additionally tested with chair-aside tests for Streptococcus mutans and Lactobacilli counts and oral sucrose clearance for preventive evaluation of dental caries management. The card validation and tests last no longer than 40 minutes, 1 page for a single patient.

Conclusions
Caries risk in adults can be measured, assessed and predicted in relation to nutrigenomics. Treatment behaviour can be managed and targeted for each patient, according to the group for long, lifetime saving of natural teeth in the mouth. In the last 100 years, concentrated and refined foods have decreased all sizes of the upper first and second incisors as a natural physiological response and a change has been observed in the anatomy of canines, making them stronger via enlargement of their MD sizes. From this current academic year, "Caries risk" is included into our new lecture programme.
Repeatability of the Calibration Protocol for Emg Evaluation of the Occlusion With the Teethan Device
Authors: Bogdanov V. 
Published: October 2024

Abstract

Objective
The aim of the study was to investigate the repeatability of the calibration protocol performed by the Teethan® device (Teethan S.p.A. Italy) for surface electromyography (sEMG) when biting on cotton rolls to eliminate the effect of occlusal contacts.

Materials and methods
Thirty-three fully dentate subjects aged 13-43 years (mean 21.33 years) of which 15 men and 18 women were enrolled in the study All subjects had a good state of dental and periodontal health without temporomandibular disorders (TMDs). Each examined participant performed two distinct maximal voluntary clenches on cotton rolls: the first one for calibration of the device and the second one for recording of the signals. The results were presented as the indices: Percentage overlapping coefficient (POC), Barycenter (BAR), Torsion (TORS), Impact (IMPACT), Global index and Asymmetry (ASIM).

Results
All the examined indices showed good repeatability during the test, compared with the normal values, determined by the manufacturer of the device. Some of the recorded indices were insignificantly lower than the norm (POC TA, POC MM, BAR and TORS). Global index and IMPACT were within the reference values and showed highest repeatability in this study.

Conclusion
Instrument calibration is an important prerequisite for exact testing. The indices, recorded by this device are rather repeatable, with Global index and Impact found to be the most repeatable ones. The values of the measured indices show that the process of calibration is highly reliable.
Exploring the impact of high shear mixing process parameters on the physical characteristics of excipient powder blend by design of experiments
Authors: Kovács Béla , Tőkés Erzsébet Orsolya , Kelemen Éva Katalin , Zöldi Katalin , Suba Edit , Kovács-Deák Boglárka , Székely-Szentmiklósi István , Boda Francisc , Casian Tibor 
Published: October 2024

Abstract

Objective
Dry-route manufacturing technology development poses challenges to pharmaceutical technology research specialists, relying on active substance characteristics, excipient selection, and parameter optimization. Amongst various technological possibilities high shear mixing generally ensures dosage uniformity and tablet dissolution through influential shear forces, potentially enhancing dry powder blend processability. This study explores the processability of a placebo formulation within the quality by design framework to address some of the aforementioned challenges.

Methods
A 24 full-factorial experimental design was used to assess the manufacturability of a placebo formulation via high shear mixing. The effect of impeller and chopper speed, high shear mixing time, and homogenization/lubrication times on powder blend rheology and compression properties was investigated.

Results
The findings of the present study showed that product critical quality attributes like resistance to crushing or disintegration time are mainly dependent on the mixing efficiency translated by the impeller speed and high shear mixing time. Software augmented process development enabled the attainment of the design space, ensuring the fulfilment of desired product performance criteria. Furthermore, the study has also shown that the careful selection of excipients is crucial in the case of dry-route manufacturing technologies, as sodium lauryl sulphate can noticeably influence the processability of powder blends due to its lubricant properties.

Conclusions
Considering the advantages and challenges raised by high-shear mixing, software aided data analysis can further augment the formulation, scale-up and lifecycle management of products developed using this technological process.
Surgical procedure for acellular vascular xenografts testing in sheep carotid artery
Authors: Harpa Marius Mihai , Puscas Alexandra Iulia , Anitei Emanuel David , Simionescu Dan Teodor , Truta Raluca Ionela , Al-Hussein Hamida , Cotfas Ionela , Ghiragosian Claudiu , Banceu Cosmin Marian , Capilna Tudor , Suciu Horatiu , Al-Hussein Hussam 
Published: October 2024

Abstract

Objective
The objective of this study is to demonstrate the safety and reproducibility of our surgical technique for implanting decellularized vascular xenografts in the carotid artery of sheep.

Methods
Acellular porcine carotid arteries were implanted as interposition xenografts in seven sheep. An intravascular shunt was used for cerebral protection, and a flowmeter was utilized to assess graft performance.

Results
There were no intraoperative deaths or postoperative neurological complications observed. Acute graft thrombosis occurred in one sheep during surgery, but was successfully managed with thrombectomy to restore blood flow. Post-implantation flowmetry and Doppler ultrasound confirmed graft functionality.

Conclusions
Our study demonstrates the successful application of our surgical method for implanting decellularized vascular xenografts in the carotid artery of sheep. The implanted grafts maintained patency, normal blood flow, and favorable wound healing and neurological outcomes post-surgery.
Research on potato tuber expansion mechanism based on multi-omics technology
Authors: Wang Huijie , Huo Liguang , Liang Suming , Li Sheng 
Published: October 2024

Abstract
In this paper, the transcriptome sequencing results were modeled and analyzed by bioinformatics statistical methods to check the sequencing quality. RNA-seq histology was used to analyze and study gene expression levels, including differential expression of genes among samples and GO functional enrichment. The transcriptome analysis could conclude that there were 1,362 differential genes among CT vs. DT groups in the expansion stage tubers, 4,670 differential genes among DWT vs. DT groups, 332 differential genes among DWT vs. CT, and 85 overlapping differential genes among DT vs CT, DWT vs DT and DWT vs CT groups, and the transcriptome data were reliable. By Go functional enrichment analysis, DT vs. CT was mostly enriched to biological processes, and DWT vs. CT vs DWT vs DT was involved in biological processes, cellular components, and molecular functions. This paper examines the molecular mechanism of potato tuber expansion that responds to drought stress and rehydration treatment through histology and bioinformatics techniques.
Multidimensional Data Analysis of Chinese Traditional Culture Integration in the Digital Transformation of Civic and Political Education in Colleges and Universities
Authors: Wang Ning 
Published: October 2024

Abstract
Civic and political education is a crucial part of China’s higher education and general education, and the new demands of the era’s development also require us to pay more attention to traditional Chinese culture. The study explores the combination of traditional Chinese culture and civic and political education in colleges and universities through a sound integration mechanism and innovative integration approach. This combination is utilized to create a digital platform and a teaching evaluation model for Civic and Political Education in colleges and universities. By evaluating the teaching quality of the digital platform for Civic and Political Education in colleges and universities and analyzing the teaching effect, the application effect of the digital platform for Civic and Political Education in colleges and universities constructed in this paper is explored. Among the 20 universities in Shanghai that conducted the experiment, the teaching effect of Civic and Political Education in universities that used the digital platform for Civic and Political Education significantly exceeded that of universities that did not adopt the digital platform for Civic and Political Education. The pre-test probability of significance of the experimental group and the control group in the four dimensions of Civic and Political Literacy, Learning Participation, Content Absorption Rate, and Traditional Cultural Identity is greater than 0.05, while the post-test probability of significance is less than 0.05, and the experimental group is significantly higher than the control group in the post-test data of the four dimensions. The digital platform for civic and political education in colleges and universities has achieved excellent teaching effects.
A Deep Learning-Based Study on the Graphic Semantic Analysis of the Children’s Picture Book “Jangal”
Authors: Yan Li , Liao Yang , chuprina Nataliia 
Published: October 2024

Abstract
Jangal contains the rich literary value and aesthetic value, which has important research significance. Through the application of deep learning technology in graphic semantic analysis, this paper specifically describes the extraction method of graphic features in the children’s picture books of “Jianggeer”. Then, the BERT framework is used as the basis to construct the graphic semantic analysis model JCDB-BRET in this paper, and it is applied to the actual analysis of the graphic semantics of the children’s picture books of “Jianggeer” after training. In this paper, the model is used to recognize all the images in the picture book and branch out their semantics to be expressed, and the proportion of geographic images in the picture book is the highest at 36.55%. The rationality and pursuit of a harmonious home in “Jianggeer” are shown through the visualization of Benba Ledu, where Jianggeer lives. The textual semantics focuses on analyzing the praise words in the picture book of Jianggeer, and the description of the “fragrance” on Jianggeer’s body and the “warm fragrance” on his neck are used as examples to elucidate the aesthetic tendency of the Mongolian people embodied in the text.