bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pendampingan Pengendalian Fungi pada Aggur Caru Club Sebagai Upaya Peningkatan Kualitas Hasil Panen
Authors: Sukendar Niken Sylvia Puspitasari , Etica Use , Rusli Latiefa , Rohman Mohamad Alim , Irawan Feri , Ahdi Istaufal 
Published: September 2024

Penyakit pada tanaman anggur dapat mempengaruhi kualitas maupun kuantitas produksi anggur. Mayoritas anggota Anggur Caru Club (ACC) masih belum mengetahui jenis penyakit pada tanaman anggur dan bagaimana cara pengendalianya. Kegiatan ini bertujuan memberikan pelatihan pengendalian fungi kepada mitra ACC. Metode pelaksanaan melalui pendampingan langsung pada mitra ACC di dusun Caru, desa Bajang, Kecamatan Mlarak, Kabupetan Ponorogo yang terdiri dari 22 anggota. Tahapan pelatihan dimulai dengan identifikasi tanaman, pelatihan dan praktek pembuatan fungisida jaddam sulfur, serta pengendalian dengan penyemprotan fungisida jaddam sulfur. Hasil dari pelatihan menunjukkan bahwa mitra ACC sudah mempu membuat fungisida jaddam sulfur , menidentifikasi tanaman yang terserang fungi, dan keterampilan penyemprotan dengan benar. Penyemprotan dilakukan seminggu sekali selama satu bulan. Dampak dari kegiatan ini membuktikan bahwa tanaman anggur yang sudah di semprot menggunakan fungisida alami dapat mengurangi hama pada tanaman anggur. Fungisida alami yang diaplikasikan ke tanaman buah hasil dari pengaplikasian fungisida alami ini mampu menguarangi penyakit pada tanaman anggur sehingga yaitu tanaman buah anggur cukup tahan terhadap penyakit dan tumbuh subur. Diperlukan kedisiplinan terkait waktu penyemprotan karena akan mempengaruhi pertumbuhan fungi yang dpaat merusak tanaman juga tidak konsisten dalam penyemprotan
Differentiation of anterior chamber pigment and inflammatory cells using swept-source optical coherence tomography: A cross-sectional study
Authors: Solebo Ameenat , Bellchambers Alice , Shu Rongling , Chu Colin , Petrushkin Harry 
Published: September 2024

Abstract

Background / Objectives:
We aimed to investigate the potential of anterior segment OCT (AS-OCT) in differentiating anterior chamber (AC) pigment and inflammatory cells.
Subject / Methods:
Cross-sectional study of adults with uveitis. Exclusion criterion was corneal opacity sufficient to obscure slit lamp examination of anterior chamber. Reference testing comprised slit lamp based detection of pigment and Standardization of Uveitis Nomenclature (SUN) grading of intraocular inflammation. Index testing comprised CASIA2 swept-source AS-OCT acquisition, with semi-automated analysis to detect and measure hyper-reflective particles within the AC. Correlations between AS-OCT derived counts of different sized particles and clinical grades were explored using multilevel multivariable regression analyses.
Results:
62 eyes (31 patients) were included. There was a positive correlation between AS-OCT particle counts of >2 pixels (equivalent to >12microns), and SUN grading (adjusted coefficient, adjCoef 52.1, 95% CI 10.1-94.0, p=0.02), strengthened in eyes clinically absent of pigment (adjCoef 69.8, 17.4-122.1, p=0.01). Positive correlation was also noted between particle counts ≤2 pixels and presence of AC pigment clinically.
Conclusions:
Swept source (SS) AS-OCT holds potential utility in differentiating between pigment and cells within the AC, leading to improved management of individuals with or at risk of intraocular inflammation. SS AS-OCT derived biomarkers may also provide information on uveitis aetiology, supporting diagnosis of underlying conditions. Further work on a larger cohort, replication by other investigators and clinical teams, and clinical correlation with anterior chamber sampling, will enable future clinical validation.
Comparison of Gd-EOB-DTPA-enhanced MRI and Contrast-enhanced Ultrasound for measuring tumor size of solitary hepatocellular carcinoma ≤ 5cm: A real-world study
Authors: Gan Leilei , Jiang Kunyuan , Chen Qiuxing , Yu Xin 
Published: September 2024

Abstract

Objective To retrospectively compare the performance of Gd-EOB-DTPA-enhanced MRI (CE-MRI) and Contrast-enhanced Ultrasound (CEUS) in measuring tumor size of solitary hepatocellular carcinoma (HCC) ≤5cm.
Methods A total of 194 patients who met the inclusion criteria from January 2019 through May 2024 were included. Taken pathological results as the reference standard, The paired T-test and Bland–Altman analysis were conducted to assess the correlation and mean absolute error between the measured maximum diameter of HCC obtained from CE-MRI/CEUS and pathological results.
Results The comparison of baseline characteristics showed that there was no significant difference between the two groups of patients undergoing MRI and CEUS (P > 0.05). Both CE-MRI and CEUS demonstrated good correlation (r > 0.7) with histological results. The paired T-test analysis revealed that CE-MRI exhibited a smaller mean absolute error (0.1 ± 6.3 mm, P = 0.224, 95%CI -0.099~0.123) compared to CEUS (4.8 ± 7.1 mm, P < 0.001, 95%CI 0.354~0.615). Furthermore, results from the subgroup of patients who underwent both CE-MRI (r = 0.896, mean absolute error 1.2 ± 4.8 mm, P = 0.094, 95%CI -0.021~0.258) and CEUS (r = 0.882, mean absolute error 3.9 ± 4.7 mm, P < 0.001, 95%CI 0.252~0.527) echoed the aforementioned conclusions. The Bland-Altman analysis indicated that both CE-MRI and CEUS consistently overestimated the size of HCC when compared to pathological results. CE-MRI (bias 0.12; 1.19 mm) demonstrated a smaller bias in both the overall patient population and the subgroup patients, as opposed to CEUS (bias 5.02; 3.90 mm).
Conclusion In the preoperative assessment of tumor sizes for solitary HCC measuring ≤5cm, Gd-EOB-DTPA-enhanced MRI exhibited superior measuring accuracy and can be more clinically useful compared to CEUS.
Involvement of Mycobacterium smegmatis small noncoding RNA B11 in triacylglycerol accumulation and altered cell wall permeability
Authors: Wu Zhuhua , Liu Weilong , Tan Qiuchan , Chen Yuhui , Lai Xiaoyu , Hong Jianming , Liang Hongdi , Wu Huizhong , Liang Jing , Chen Xunxun 
Published: September 2024

Abstract

Background Mycobacterium tuberculosis (M. tuberculosis) is known to causesevere lung disease in patients.Pathways involving triacylglycerol (TAG) accumulationare thought to play a crucial regulatory role in bacterial growth and metabolism. Despite this understanding, little is known about the biological functions and regulatory mechanisms of small RNAs in M. tuberculosis. Mycobacterium smegmatis (M. smegmatis), a type of Mycobacterium, serves as a model organism to investigate the molecular, physiological, and drug resistance features of M. tuberculosis.
Results In this study, we demonstrated that overexpression of B11 significantly affects bacterial growth and colony morphology, increases antibiotic sensitivity and sodium dodecyl sulfate (SDS) surface stress, decreases intracellular survival, and suppresses cytokinesecretion in macrophages. Transcriptomic and lipidomic analyses revealed a metabolic downshift in the B11 overexpression strain, characterized by reduced levels of TAG. Furthermore, transmission electron microscopy showed that the B11 overexpression strain exhibited decreased cell wall thickness, leading to reduced biofilm formation and altered cell wall permeability. Additionally, we observed that B11 regulated certain target genes but did not directly bind to proteins.
Conclusions Taken together, these findings suggest that B11 plays important roles in Mycobacterium survival under antibiotic and SDS stresses, TAG accumulation, and contributes to antibiotic sensitivity through altered cell wall permeability.
Diagnosis and Risk Stratification of PI-RADS v2.1 Category 3–5 Lesions Using Amide Proton Transfer Imaging
Authors: Fang Hongkun , Hou Weishu , Wang Qun , Zhang Xiaoyu , Wang Xiao , Zhang Shuhai , Li Shoubin , Li Xiaohu , Yu Yongqiang 
Published: September 2024

Abstract

Objectives: To explore the value of amide proton transfer-weighted imaging (APTWI) combined with apparent diffusion coefficient (ADC) and prostate-specific antigen density (PSAD) in evaluating the risk of aggressive PI-RADS v2.1 category 3–5 lesions.
Materials and Methods: We retrospectively analyzed clinical and MRI features of 69 patients with prostate cancer (PCa) and 32 patients with benign prostatic lesion (BL). The PCa group was classified into Gleason Grade Groups (GG) 1 to 4 based on Gleason Score (GS). APTWI parameters, ADC, and PSAD were compared among the different groups. The receiver operating characteristic (ROC) curve was used to assess the diagnostic accuracy of each parameter, and Spearman rank correlation was used to analyze the relationship between APTWI parameters and GS.
Results: APTWI parameters, ADC, and PSAD were significantly higher in the PCa group than in the BL group, whereas ADC was significantly lower in the PCa group than in the BL group. ADC showed the highest AUC in the diagnosis of PCa, followed by PSAD and APTmin. Combined analysis showed that APTmin+ADC+PSAD exhibited the highest AUC (0.997). In the PCa group, significant differences in APTWI parameters were found among GG1 to GG4 (P<0.001), with intra-group comparisons showing significant differences between GG1 and GG3, GG1 and GG4, GG2 and GG3, and GG2 and GG4 subgroups. The AUC of APTmean was greatest in evaluating the risk of aggressive PCa (0.843), which further increased when APTmean was combined with ADC and PSAD (0.859).
Conclusion: In PI-RADS v2.1 category 3–5 lesions, APT can serve as an important biomarker for the risk stratification of PCa, and combining APT with PSAD and ADC achieves the highest diagnostic efficacy.
Healthcare utilization and clinical outcomes between remodeled and conventional respiratory departments in treating COVID-19 patients during omicron period in China: a propensity score-matched study
Authors: Tang Xiumei , Zhou Ailing , Li Yuhang , Li Kai , Ma Li , Li Weimin 
Published: September 2024

Abstract

Purpose
This study aims to compare the clinical outcomes and healthcare costs of COVID-19 patients treated in either conventional or remodeled respiratory departments at a large medical center in China.
Methods
Using propensity score matching, we selected COVID-19 patients treated between December 2022 and February 2023. We compared all-cause in-hospital mortality as the primary outcome, along with secondary outcomes including length of hospitalization, rates of patients with critical illness complications, COVID-19 related treatments, and healthcare costs.
Results
Among the 5,102 COVID-19 patients treated during the study period, 4,553 (89.24%) were in the remodeled respiratory department, and 549 (10.76%) were in the conventional department. The final analysis included 1,633 propensity score-matched patients from the remodeled department and 549 from the conventional department at a ratio of 1:3. There were no significant differences in all-cause in-hospital mortality or length of hospitalization between the two groups. However, patients in the remodeled department had significantly higher rates of cerebrovascular complications (13.65% vs 8.74%, p = 0.003), higher rates of critical illnesses (3.61% vs 1.50% vs, p = 0.017), higher healthcare costs (7,400 vs 4,300, p < 0.001), while lower rates of respiratory complications (86.22% vs 99.63%, p < 0.001) and non-critical illnesses (45.19% vs 58.83%, p < 0.001). Patients in remodeled department received more invasive oxgen treatment than their counterpart while there was no difference regarding medication administering between the two groups.
Conclusions
During the COVID-19 pandemic, treatment in the remodeled respiratory department was associated with a higher incidence of critical illness and increased healthcare costs, but similar all-cause in-hospital mortality and length of hospitalization compared to the conventional department. Temporarily remodeling hospital infrastructure to expand respiratory care capacity can be a safe and effective strategy to manage surges in COVID-19 cases or other respiratory disorders at the expense of higer cost.
Brain age mediates gut microbiome dysbiosis-related cognition in older adults
Authors: Son Sang Joon , Lee Dong Yun , Roh Hyun Woong , Ly Maria , Kolobaric Antonija , Aizenstein Howard , Andreescu Carmen , Jašarević Eldin , Pascoal Tharick A. , Ferreira Pamela C. L , Bellaver Bruna , Cho Yong Hyuk , Hong Sunhwa , Nam You Jin , Park Bumhee , Kim Narae , Choi Jin Wook , Cheong Jae Youn , Kim Yoon-Keun , Shin Tae-Seop , Kang Chil-Sung , Kwon Cheol-O , Yoon Seo-Yoon , Hong Chang Hyung , Karim Helmet T. 
Published: September 2024

Abstract

Background Recent studies have focused on improving our understanding of gut microbiome dysbiosis and its impact on cognitive function. However, the relationship between gut microbiome composition, accelerated brain atrophy, and cognitive function has not yet been fully explored.Methods We recruited 292 participants from South Korean memory clinics to undergo brain magnetic resonance imaging, clinical assessments, and collected stool samples. We employed a pretrained brain age model– a measure associated with neurodegeneration. Using cluster analysis, we categorized individuals based on their microbiome profiles and examined the correlations with brain age, Mental State Examination (MMSE) scores, and the Clinical Dementia Rating Sum of Box (CDR-SB).Results Two clusters were identified in the microbiota at the phylum level that showed significant differences on a number of microbiota phylum. Greater gut microbiome dysbiosis was associated with worse cognitive function including MMSE and CDR-SB; this effect was partially mediated by greater brain age even when accounting for chronological age, sex, and education.Conclusions Our findings indicate that brain age mediates the link between gut microbiome dysbiosis and cognitive performance. These insights suggest potential interventions targeting the gut microbiome to alleviate age-related cognitive decline.
Post-transplant cyclophosphamide plus anti-thymocyte globulin lowered serum IL-6 levels compared with post-transplant cyclophosphamide alone after haploidentical hematopoietic stem cell transplantation
Authors: Koh Jeong Suk , Lee Myung-Won , Pham Thi Thuy Duong , Heo Bu Yeon , Choi Suyoung , Lee Sang-Woo , Seo Wonhyoung , Kang Sora , Lee Seul Bi , Kim Chul Hee , Ryu Hyewon , Eun Hyuk Soo , Lee Hyo-Jin , Yun Hwan-Jung , Jo Deog-Yeon , Song Ik-Chan 
Published: September 2024

Abstract

Background: Post-transplant cyclophosphamide (PTCy) and anti-thymocyte globulin (ATG) are both common prophylactic strategies for graft-versus-host disease (GVHD) in haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Interleukin (IL)-6 is a surrogate marker for cytokine release syndrome (CRS) and acute GVHD.
Method: This study compared the clinical outcomes and complications of haplo-HSCT with PTCy plus ATG versus PTCy monotherapy according to serum IL-6 levels at Chungnam National University Hospital (Daejeon, South Korea) from January 2019 to February 2023.
Results: Forty patients who underwent haplo-HSCT were analyzed. There was a significant difference in IL-6 levels between the PTCy plus ATG and PTCy alone groups (7.47 ± 10.55 vs. 117.65 ± 127.67; p = 0.003). More patients in the PTCy plus ATG group had CRS grade 0 than in the PTCy alone group (p < 0.001). Serum IL-6 levels were associated with grade II-IV acute GVHD (r = 0.547, p <0.001). The cumulative incidence (CI) of grade II–IV acute GVHD was significantly higher in the PTCy alone group (67.9% vs. 4.8%; p <0.001). There was no significant difference in the CI of chronic GVHD between the PTCy plus ATG and PTCy alone groups (72.1% vs. 82.0%; p = 0.730). The CI of 1-year non-relapse mortality was significantly higher in the PTCy alone group compared with the PTCy plus ATG group (42.2% vs. 15.9%; p = 0.022). The 1-year overall survival (OS) was significantly better in the PTCy plus ATG group (75.9% vs. 35.3%; p = 0.011).
Conclusion: Serum IL-6 levels were higher with PTCy alone than with PTCy plus ATG. The addition of ATG before stem cell infusion affects IL-6 levels and reduces the incidences of CRS and grade II–IV acute GVHD in haplo-HSCT. This study suggests that PTCy plus ATG as GVHD prophylaxis in haplo-HSCT is beneficial in terms of the clinical outcomes and complications of HSCT.
Delayed temporal intraparenchymal hemorrhage caused by rupture of middle meningeal artery pseudoaneurysm after a temporal rim fracture
Authors: Cheng Chen-Ting , Chiu Cheng-Di , Chen Wei-Liang , Guo Jeng-Hung 
Published: September 2024

Abstract

Middle meningeal artery (MMA) pseudoaneurysms are mostly caused by traumatic brain injury and can lead to severe morbidity because of epidural or subdural hematoma. We present a rare case of delayed rupture of a right MMA pseudoaneurysm that caused a temporal intraparenchymal hemorrhage (IPH). Delayed rupture of an MMA pseudoaneurysm is rare but has devastating consequences. Digital subtraction angiography in patients with traumatic brain injury with temporal rim fracture and temporal IPH may help diagnose this lesion easily and treat the disease earlier.
A retrospective study investigating the risk of graft loss in living donor liver transplant cases where size mismatching is predicted from graft-to-recipient weight ratio
Authors: Toriigahara Yukihiro , Matsuura Toshiharu , Takahashi Yoshiaki , Uchida Yasuyuki , Kajihara Keisuke , Maeda Shohei , Kawakubo Naonori , Nagata Kouji , Tajiri Tatsuro 
Published: September 2024

Abstract

Background/Purpose:
Living donor liver transplantation (LDLT) is vital for pediatric end-stage liver disease due to organ shortages. The graft-to-recipient weight ratio (GRWR) preoperatively measured predicts the outcomes of LDLT. We typically target between 0.8% and 3.0–4.0%, but the ideal GRWR remains controversial. We compared the outcomes of LDLT according to the GRWR to examine whether the criteria could be expanded while ensuring safety.
Methods:
We retrospectively reviewed 99 patients who underwent LDLT in our department by dividing them into three groups according to their GRWR: Group S, with GRWR values lower than the normal range (GRWR < 0.8%); Group M, with GRWR values in the normal range (GRWR ≥ 0.8 to < 3.5%); and Group L, with GRWR values above the normal range (GRWR ≥ 3.5%).
Results:
In Groups S and L, 46.2% and 44.4% of patients underwent splenectomy and delayed abdominal wall closure, respectively. After these intraoperative adjustments, there were no significant differences between the groups in 5-year patient survival, 5-year graft survival, or the occurrence of post-transplantation thrombosis.
Conclusion:
When the GRWR is beyond the normal threshold, the risk of complications associated with graft size might be reduced by adjustments to provide appropriate portal blood flow and by delayed abdominal wall closure.
Can Malnutrition, Dietary Habits, and Diet Quality Be Determinant Factors in Frailty, Sarcopenia, Low Physical Function, and Depression in the Elderly?
Authors: Pehlivan Merve , Bakırhan Hande , Arpa Fatmanur Ozyürek , Irgat Serap Incedal 
Published: September 2024

Abstract

This study aimed to investigate the association between malnutrition, diet quality, and dietary intake and frailty, sarcopenia, low physical function, and depression in the elderly. The Edmonton Frailty Scale, Sarcopenia Rapid Screening Test, Katz Activities of Daily Living Scale for the Elderly, Geriatric Depression Scale, Mini Nutritional Assessment- Short Form, and Mediterranean Diet Adherence score scales were administered to all study participants (n=695) to determine frailty, sarcopenia, physical status, depression status, nutritional status and adherence to the Mediterranean diet. Participants' dietary acid load was assessed using the Potential Renal Acid Load and Net Endogenous Acid Production indicators. Women had significantly higher levels of frailty and sarcopenia compared to men (p<0.05). Frailty and sarcopenia status were correlated with each other, and it was observed that GDS scores increased significantly while KATZ scores decreased as their severity increased (p<0.05). MNA and MEDAS scores correlated with the EFS (r=-0.508, p=0.000; r=-0.084, p=0.027, respectively), SARC-F (r=-0.358, p=0.000; r=-0.126; p=0.001, respectively), GDS (r=-0.397, p=0.000, r=-0,243, p=0,000, respectively), while KATZ and MNA (r=0,439) were found to be positively correlated with energy (r=0,133) and protein (r=0,119) intake (p<0,05). As the PRAL score increased, the GDS (r=-0.082; p=0.031), the SARC-F (r=-0.087; p=0.022), and the EFS (r=-119, p=0.002) decreased significantly. Each 1-unit increase in the MNA score caused a decrease of 0.857, 0.431, and 1.201 units in the EFS, SARF-C, and GDS, respectively, and an increase of 0.190 units in the KATZ. Malnutrition status is positively associated with frailty, sarcopenia, low physical activity, and depression.
Human neutrophil lipocalin, procalcitonin, c-reactive protein, and leucocyte count for prediction of bacterial sepsis in emergency department patients
Authors: Benhamou Jonathan , Nieves-Ortega Ricardo , Nickel Christian H. , Lampart Alina , Kuster Tobias , Balestra Gianmarco M. , Rosin Christiane , Becker Christoph , Lippay Kriemhild , Bingisser Roland 
Published: September 2024

Abstract

Background: Delayed identification of bacterial sepsis undermines the initiation of antibiotic and other time-sensitive treatments in the emergency department (ED). We aimed to investigate the performance of human-neutrophil lipocalin (HNL), procalcitonin (PCT), C-reactive protein (CRP), and leucocyte count in conjunction with clinical scores for the early detection of bacterial sepsis.
Methods: Patients presenting to the emergency department (ED) with a suspected infection and a national early warning score (NEWS) ≥2 at triage were screened for eligibility. The study biomarkers were measured at ED presentation. The primary outcome was bacterial sepsis, defined as an acute bacterial infection and an increase of ≥2 points in the sequential organ failure assessment (SOFA) score (Sepsis-3 criteria). The diagnostic accuracy of the biomarkers for bacterial sepsis was calculated using receiver operating curve (ROC) analysis and its area under the curve (AUC) with 95 % confidence intervals (CI).
Results: In total, we included 421 patients, of whom 155 (36.8%) had bacterial sepsis. For the prediction of bacterial sepsis, PCT outperformed the other biomarkers with an AUC (95% CI) of 0.77 (0.72 – 0.82), compared to HNL 0.72 (0.67 – 0.77), CRP 0.71 (0.66 - 0.76), and leucocyte count 0.64 (0.59 – 0.70). A combination of serum HNL with NEWS and SOFA at presentation had the best predictive value for bacterial sepsis (AUC 0.83).
Conclusion: A combination of biomarkers (serum HNL or CRP plus leucocytes) with NEWS and SOFA at presentation outperformed inflammatory biomarkers used individually in the prediction of bacterial sepsis.