bluuebunny/crossref_metadata_2025_split huggingface dataset:
Недостатки и достоинства разных систем транскрипции при записи говора старообрядцев в Польше
Authors: Яскульски [Jaskólski] Адам [Adam] 
Published: January 2016

Advantages and disadvantages of different types of phonetic transcription for notation of the dialect of Old Believers in Poland The author presents the problems associated with the phonetic representation of the dialect of the Old Believers in Poland in the conditions of bilingualism. The Old Believers’ Russian dialect is has been under influence of the Polish language for over a century. On the phonetic level the main expressions of interference are: pronunciation of palatal consonants [ś], [ź], [ć], [ʒ́], [ń] instead of Russian soft coronal conso­nants [s’], [z’], [t’], [d’], [n’] as well as pronunciation of the labial glide [w] instead of Russian velarized lateral consonant [ł]. In the conditions of bilingualism using only a Russian phonetic transcription seems to be insufficient, since it does not include signs for notation sounds which turned up in the Russian dialect under the influence of Polish phonetics. With reference to the mentioned above one should use a more universal transcription system. Since in the studied dialect numerous elements of two languages are coexisting and both of them are Slavonic languages, the author proposes the use of Slavonic transcription system for notation of Polish Old Believers’ speech. Wady i zalety różnych systemów transkrypcji przy zapisie fonetycznym gwary polskich staroobrzędowców W artykule autor przedstawia problemy związane z zapisem fonetycznym gwary polskich staroobrzędowców w warunkach dwujęzyczności, a także proponuje sposoby ich rozwiązania. Rosyjska gwara polskich staroobrzędowców podlega stałemu wpływowi języka polskiego. Głównymi przejawami interferencji na poziomie fonetycznym jest wymowa spółgłosek palatalnych [ś], [ź], [ć], [ʒ́], [ń] na miejscu rosyjskich miękkich przedniojęzykowych spółgłosek [s’], [z’], [t’], [d’], [n’], a także wymowa glajdu wargowego [w] zamiast rosyjskiej welaryzowanej spółgłoski lateralnej [ł]. W warunkach dwujęzyczności niewystarczającym wydaje się użycie tylko rosyjskiego systemu transkrypcji, ponieważ brakuje w nim znaków do oznaczenia dźwięków, które pojawiły się w gwarze polskich staroobrzędowców pod wpływem polskiej fonetyki. W związku z powyższym powinien być użyty bardziej uniwersalny system transkrypcji lub system mieszany, wykorzystujący znaki różnych alfabetów fonetycznych. Ponieważ w badanej gwarze współistnieją liczne elementy dwóch języków i obydwa te języki są słowiańskie, do jej zapisu fonetycznego optymalny wydaje się slawistyczny system transkrypcji.
Irena Maryniakowa, Dorota K. Rembiszewska, Janusz Siatkowski, Różnojęzyczne słownictwo gwarowe Podlasia, Suwalszczyzny i północno-wschodniego Mazowsza, Warszawa: Instytut Slawistyki PAN, 2014, 476 ss.
Authors: Głuszkowski Michał 
Published: January 2016

Review The monograph Różnojęzyczne słownictwo gwarowe Podlasia, Suwalszczyzny i północno-wschodniego Mazowsza is a result of an innovative, holistic approach in lexicography. The authors are not interested in separate languages, but in a specified linguistic area as a whole. The contact of Polish, Lithuanian and Eastern-Slavonic dialects in North East Poland lasts several centuries and it is impossible to set the borders between these codes. Thus, the holistic approach is the best theoretical solution in question. Recenzja Opracowanie Różnojęzyczne słownictwo gwarowe Podlasia, Suwalszczyzny i północno-wschodniego Mazowsza jest efektem nowatorskiego, kompleksowego podejścia badawczego w leksykografii. Przedmiotem badań nie są poszczególne systemy językowe, lecz pewien obszar językowy jako całość. Wielowiekowy kontakt gwar polskich, wschodniosłowiańskich i litewskich na terenach północno-wschodniej Polski uniemożliwia jednoznaczne określenie ich granic, w związku z czym ujęcie holistyczne jest ze wszech miar uzasadnione.
Teksty ze wsi Darwinieki oraz z Iłukszty na Łotwie z komentarzem językowym
Authors: Ostrówka Małgorzata Maria 
Published: January 2016

Texts from the villages Darvinieki and Iłukszta in Latvia with linguistic commentsThe study contains dialect texts recorded in the village Darvinieki in the 1960s by Józefa Parszuta (a researcher of the Polish language who was born in Latvia) and texts recorded by the author in Iłukszta in 2001. The texts are preceded with a linguistic comment including a description of the most important phonetic, morphological and syntactic features which are characteristic of the Polish north borderland dialect. Teksty ze wsi Darwinieki oraz z Iłukszty na Łotwie z komentarzem językowymOpracowanie zawiera teksty gwarowe zapisane we wsi Darwinieki w latach 60. XX w. przez Józefę Parszutę, urodzoną na Łotwie badaczkę języka polskiego, oraz teksty nagrane przez autorkę w Iłukszcie w roku 2001. Teksty poprzedza komentarz językowy, zawierający opis najważniejszych cech fonetycznych, fleksyjnych i składniowych, charakterystycznych dla polszczyzny północnokresowej.
Relative Roles of Dynamic and Thermodynamic Processes in Causing Evolution Asymmetry between El Niño and La Niña*
Authors: Chen Mingcheng , Li Tim , Shen Xinyong , Wu Bo 
Published: January 2016

Abstract
Observed SST anomaly (SSTA) in the equatorial eastern Pacific exhibits an asymmetric evolution characteristic between El Niño and La Niña. While El Niño is characterized by a rapid decay after its peak and a fast phase transition to a cold episode in the following winter, La Niña is characterized by a weaker decay after its peak and a reintensification of cold SSTA in the second year. The relative roles of dynamic (wind field) and thermodynamic (heat flux) processes in causing the asymmetric evolutions are investigated through a mixed layer heat budget analysis. The result shows both dynamic and thermodynamic processes contribute to the evolution asymmetry. The former is related to asymmetric wind responses in the western Pacific, whereas the latter is associated with asymmetric cloud–radiation–SST and evaporation–SST feedbacks. A strong negative SSTA tendency occurs during El Niño decaying phase, compared to a much weaker positive SSTA tendency during La Niña decaying phase. Such a difference leads to an SSTA sign change for El Niño but no sign change for La Niña by the end of summer of the second year. A season-dependent coupled instability kicks in during northern fall, leading to the development of a La Niña by end of the second year for El Niño, but the reoccurrence of a La Niña episode by end of the second year for La Niña. The overall heat budget analysis during the entire ENSO evolutions indicates the thermodynamic process is as important as the dynamic process in causing the El Niño–La Niña evolution asymmetry. The fundamental difference of the current result with previous theories is further discussed.
POMC expression of the urothelium of the urinary bladder of mice submitted to pelvic radiation
Authors: Ozbilgin M Kemal , Aktas Caner , Temel Merve , Önal Tuna , Türköz Uluer Elgin , Vatansever H Seda , Kurtman Cengiz 
Published: January 2016

Objective: Patients who have had pelvic radiotherapy as part of their cancer therapy may develop subsequent urinary bladder injury. The acute changes that the urothelium undergo after radiation are known, but the healing mechanism of the urothelium of the urinary bladder after pelvic radiotherapy is not clearly understood. Proopiomelanocortin (POMC) peptides, which have immunomodulatory effects, are produced locally in sites outside of the central nervous system. This study aims to determine the role of POMC expression in the urothelium during radiation injury. Methods: Twenty-four male Swiss Albino mice were divided into four groups. A single-fractioned 10 Gy of ionizing radiation was applied to the pelvic zone of all mice with Cobalt-60 radiotherapy. The first group 1, which consisted intact animal and not irradiated was the control group, and the second, third, and fourth groups were euthanized after 24 h (Group 2), 48 h (Group 3), and 7 days (Group 4) after irradiation. All bladders were prepared for histochemical analysis using hematoxylin eosin (H&E) and immunohistochemical analysis using anti-POMC antibody. Results: No morphological differences were seen in all the group samples stained with H&E. POMC expression of the urothelium of bladder tissue samples shows different staining levels. Group 1 (96.7 ± 7.68), Group 2 (88.3 ± 8.04), and Group 3 (85.10 ± 10.9) were very weakly stained, but the POMC immunoreactivity of Group 4 (113.0 ± 12.8) was observed to be strong. Conclusion: Expression of POMC from urothelium seems to prevent bladder damage from radiation supplying differentiation and restoration of the urothelium.
Increased DNA methylation of Dnmt3b targets impairs leukemogenesis
Authors: Schulze Isabell , Rohde Christian , Scheller-Wendorff Marina , Bäumer Nicole , Krause Annika , Herbst Friederike , Riemke Pia , Hebestreit Katja , Tschanter Petra , Lin Qiong , Linhart Heinz , Godley Lucy A. , Glimm Hanno , Dugas Martin , Wagner Wolfgang , Berdel Wolfgang E. , Rosenbauer Frank , Müller-Tidow Carsten 
Published: January 2016

Key PointsIncreased gene body methylation inhibits leukemia, and oncogenes require varying levels of DNA methylation for efficient leukemogenesis. Dnmt3b-induced DNA methylation in mice targets stem cell–associated genes with prognostic association in acute myeloid leukemia patients.
Efficient and automated large-scale detection of structural relationships in proteins with a flexible aligner
Authors: Gutiérrez Fernando I. , Rodriguez-Valenzuela Felipe , Ibarra Ignacio L. , Devos Damien P. , Melo Francisco 
Published: January 2016

Abstract
Background
The total number of known three-dimensional protein structures is rapidly increasing. Consequently, the need for fast structural search against complete databases without a significant loss of accuracy is increasingly demanding. Recently, TopSearch, an ultra-fast method for finding rigid structural relationships between a query structure and the complete Protein Data Bank (PDB), at the multi-chain level, has been released. However, comparable accurate flexible structural aligners to perform efficient whole database searches of multi-domain proteins are not yet available. The availability of such a tool is critical for a sustainable boosting of biological discovery.

Results
Here we report on the development of a new method for the fast and flexible comparison of protein structure chains. The method relies on the calculation of 2D matrices containing a description of the three-dimensional arrangement of secondary structure elements (angles and distances). The comparison involves the matching of an ensemble of substructures through a nested-two-steps dynamic programming algorithm. The unique features of this new approach are the integration and trade-off balancing of the following: 1) speed, 2) accuracy and 3) global and semiglobal flexible structure alignment by integration of local substructure matching. The comparison, and matching with competitive accuracy, of one medium sized (250-aa) query structure against the complete PDB database (216,322 protein chains) takes about 8 min using an average desktop computer. The method is at least 2–3 orders of magnitude faster than other tested tools with similar accuracy. We validate the performance of the method for fold and superfamily assignment in a large benchmark set of protein structures. We finally provide a series of examples to illustrate the usefulness of this method and its application in biological discovery.

Conclusions
The method is able to detect partial structure matching, rigid body shifts, conformational changes and tolerates substantial structural variation arising from insertions, deletions and sequence divergence, as well as structural convergence of unrelated proteins.
Influence of different electrode belt positions on electrical impedance tomography imaging of regional ventilation: a prospective observational study
Authors: Karsten Jan , Stueber Thomas , Voigt Nicolas , Teschner Eckhard , Heinze Hermann 
Published: January 2016

Abstract
Background
Electrical impedance tomography (EIT) is a non-invasive bedside tool which allows an individualized ventilator strategy by monitoring tidal ventilation and lung aeration. EIT can be performed at different cranio-caudal thoracic levels, but data are missing about the optimal belt position. The main goal of this prospective observational study was to evaluate the impact of different electrode layers on tidal impedance variation in relation to global volume changes in order to propose a proper belt position for EIT measurements.

Methods
EIT measurements were performed in 15 mechanically ventilated intensive care patients with the electrode belt at different thoracic layers (L1-L7). All respiratory and hemodynamic parameters were recorded. Blood gas analyses were obtained once at the beginning of EIT examination. Off-line tidal impedance variation/tidal volume (TV/VT) ratio was calculated, and specific patterns of impedance distribution due to automatic and user-defined adjustment of the colour scale for EIT images were identified.

Results
TV/VT ratio is the highest at L1. It decreases in caudal direction. At L5, the decrease of TV/VT ratio is significant. We could identify patterns of diaphragmatic interference with ventilation-related impedance changes, which owing to the automatically adjusted colour scales are not obvious in the regularly displayed EIT images.

Conclusions
The clinical usability and plausibility of EIT measurements depend on proper belt position, proper impedance visualisation, correct analysis and data interpretation. When EIT is used to estimate global parameters like VT or changes in end-expiratory lung volume, the best electrode plane is between the 4th and 5th intercostal space. The specific colour coding occasionally suppresses user-relevant information, and manual rescaling of images is necessary to visualise this information.
The future of antiviral immunotoxins
Authors: Spiess Katja , Jakobsen Mette Høy , Kledal Thomas N , Rosenkilde Mette M 
Published: January 2016

Abstract
There is a constant need for new therapeutic interventions in a wide range of infectious diseases. Over the past few years, the immunotoxins have entered the stage as promising antiviral treatments. Immunotoxins have been extensively explored in cancer treatment and have achieved FDA approval in several cases. Indeed, the design of new anticancer immunotoxins is a rapidly developing field. However, at present, several immunotoxins have been developed targeting a variety of different viruses with high specificity and efficacy. Rather than blocking a viral or cellular pathway needed for virus replication and dissemination, immunotoxins exert their effect by killing and eradicating the pool of infected cells. By targeting a virus-encoded target molecule, it is possible to obtain superior selectivity and drastically limit the side effects, which is an immunotoxin-related challenge that has hindered the success of immunotoxins in cancer treatment. Therefore, it seems beneficial to use immunotoxins for the treatment of virus infections. One recent example showed that targeting of virus-encoded 7 transmembrane (7TM) receptors by immunotoxins could be a future strategy for designing ultraspecific antiviral treatment, ensuring efficient internalization and hence efficient eradication of the pool of infected cells, both in vitro and in vivo. In this review, we provide an overview of the mechanisms of action of immunotoxins and highlight the advantages of immunotoxins as future anti-viral therapies.
Antibody blockade of IL-17 family cytokines in immunity to acute murine oral mucosal candidiasis
Authors: Whibley Natasha , Tritto Elaine , Traggiai Elisabetta , Kolbinger Frank , Moulin Pierre , Brees Dominique , Coleman Bianca M , Mamo Anna J , Garg Abhishek V , Jaycox Jillian R , Siebenlist Ulrich , Kammüller Michael , Gaffen Sarah L 
Published: January 2016

Abstract
Antibodies targeting IL-17A or its receptor, IL-17RA, are approved to treat psoriasis and are being evaluated for other autoimmune conditions. Conversely, IL-17 signaling is critical for immunity to opportunistic mucosal infections caused by the commensal fungus Candida albicans, as mice and humans lacking the IL-17R experience chronic mucosal candidiasis. IL-17A, IL-17F, and IL-17AF bind the IL-17RA-IL-17RC heterodimeric complex and deliver qualitatively similar signals through the adaptor Act1. Here, we used a mouse model of acute oropharyngeal candidiasis to assess the impact of blocking IL-17 family cytokines compared with specific IL-17 cytokine gene knockout mice. Anti-IL-17A antibodies, which neutralize IL-17A and IL-17AF, caused elevated oral fungal loads, whereas anti-IL-17AF and anti-IL-17F antibodies did not. Notably, there was a cooperative effect of blocking IL-17A, IL-17AF, and IL-17F together. Termination of anti-IL-17A treatment was associated with rapid C. albicans clearance. IL-17F-deficient mice were fully resistant to oropharyngeal candidiasis, consistent with antibody blockade. However, IL-17A-deficient mice had lower fungal burdens than anti-IL-17A-treated mice. Act1-deficient mice were much more susceptible to oropharyngeal candidiasis than anti-IL-17A antibody-treated mice, yet anti-IL-17A and anti-IL-17RA treatment caused equivalent susceptibilities. Based on microarray analyses of the oral mucosa during infection, only a limited number of genes were associated with oropharyngeal candidiasis susceptibility. In sum, we conclude that IL-17A is the main cytokine mediator of immunity in murine oropharyngeal candidiasis, but a cooperative relationship among IL-17A, IL-17AF, and IL-17F exists in vivo. Susceptibility displays the following hierarchy: IL-17RA- or Act1-deficiency &gt; anti-IL-17A + anti-IL-17F antibodies &gt; anti-IL-17A or anti-IL-17RA antibodies &gt; IL-17A deficiency.
Lowered Cisplatin Dose and No Bleomycin in the Treatment of Pediatric Germ Cell Tumors: Results of the GCT-99 Protocol From the Brazilian Germ Cell Pediatric Oncology Cooperative Group
Authors: Lopes Luiz Fernando , Macedo Carla Renata Pacheco Donato , Aguiar Simone dos Santos , Barreto Jose Henrique S. , Martins Gisele Eiras , Sonaglio Viviane , Milone Marcelo , Lima Eduardo Ribeiro , Almeida Maria Teresa de Assis , Lopes Paula Maria Azevedo Allemand , Watanabe Flora Mitie , D´Andrea Maria Lydia Mello , Pianovski Mara Albonei , Melaragno Renato , Vianna Sonia Maria Rossi , Moreira Mauber Eduardo Schultz , Bruniera Paula , Zanardo de Oliveira Cleyton 
Published: January 2016

Purpose We describe the results of a risk-adapted, response-based therapeutic approach from the Brazilian GCT-99 study on germ cell tumors. Patients and Methods From May 1999 to October 2009, 579 participants were enrolled in the Brazilian GCT-99 study. Treatment, defined as specific chemotherapy regimen and number of cycles, was allocated by means of risk-group assignment at diagnosis with consideration for stage and primary tumor site. Patients at low risk received no chemotherapy. Patients at intermediate risk (IR) with a good response (GR) received four cycles of platinum and etoposide (PE), for total doses of platinum 420 mg/m2 and etoposide 2,040 mg/m2. Patients at IR with a partial response (PR) received three cycles of PE plus three cycles of ifosfamide, vinblastine, and bleomycin. Patients at high risk (HR) with a GR received four cycles of PE and ifosfamide (PEI) at total doses of platinum 420 mg/m2, etoposide 1,200 mg/m2, and ifosfamide 30 g/m2. Patients at HR with a PR received six cycles of PEI. Results The risk-group distribution was 213 LR, 138 IR, and 129 HR for 480 evaluable patients. Overall survival (OS) and event-free survival (EFS) rates at 10 years were, respectively, 90% and 88.6% in the IR-GR group (n = 126) and 74.1% and 74.1% in the IR-PR group (n = 12). Ten-year rates for the HR-GR group (n = 86) were an OS of 66.8% and an EFS of 62.5%. The HR-PR group (n = 43) had an OS of 74.8% and an EFS of 73.4%. In univariable and multivariable analysis, increased serum lactate dehydrogenase level and histology for a metastatic immature teratoma were prognostic of a worsened outcome. Conclusion Reduction of therapy to two drugs did not compromise survival outcomes for patients in the IR-GR group, and escalation of therapy with PEI did not significantly improve OS and EFS in patients at HR.
Importance of Radiation Oncologist Experience Among Patients With Head-and-Neck Cancer Treated With Intensity-Modulated Radiation Therapy
Authors: Boero Isabel J. , Paravati Anthony J. , Xu Beibei , Cohen Ezra E.W. , Mell Loren K. , Le Quynh-Thu , Murphy James D. 
Published: January 2016

Purpose Over the past decade, intensity-modulated radiation therapy (IMRT) has replaced conventional radiation techniques in the management of head-and-neck cancers (HNCs). We conducted this population-based study to evaluate the influence of radiation oncologist experience on outcomes in patients with HNC treated with IMRT compared with patients with HNC treated with conventional radiation therapy. Methods We identified radiation providers from Medicare claims of 6,212 Medicare beneficiaries with HNC treated between 2000 and 2009. We analyzed the impact of provider volume on all-cause mortality, HNC mortality, and toxicity end points after treatment with either conventional radiation therapy or IMRT. All analyses were performed by using either multivariable Cox proportional hazards or Fine-Gray regression models controlling for potential confounding variables. Results Among patients treated with conventional radiation, we found no significant relationship between provider volume and patient survival or any toxicity end point. Among patients receiving IMRT, those treated by higher-volume radiation oncologists had improved survival compared with those treated by low-volume providers. The risk of all-cause mortality decreased by 21% for every additional five patients treated per provider per year (hazard ratio [HR], 0.79; 95% CI, 0.67 to 0.94). Patients treated with IMRT by higher-volume providers had decreased HNC-specific mortality (subdistribution HR, 0.68; 95% CI, 0.50 to 0.91) and decreased risk of aspiration pneumonia (subdistribution HR, 0.72; 95% CI, 0.52 to 0.99). Conclusion Patients receiving IMRT for HNC had improved outcomes when treated by higher-volume providers. These findings will better inform patients and providers when making decisions about treatment, and emphasize the critical importance of high-quality radiation therapy for optimal treatment of HNC.