bluuebunny/crossref_metadata_2025_split huggingface dataset:
Belatacept conversion in African American kidney transplant recipients with severe renal dysfunction
Authors: Snyder Heather S , Duhart Benjamin T , Krauss Amy G , Rao Vinaya 
Published: November 2016

Objectives: Conversion from calcineurin inhibitor–based maintenance immunosuppression to belatacept in kidney transplant recipients has been demonstrated to improve renal function while maintaining efficacy against rejection. However, conversion studies to date have excluded patients with an estimated glomerular filtration rate < 35 mL/min/1.73 m2. Methods: We describe two patients with an estimated glomerular filtration rate < 30 mL/min/1.73 m2 who underwent conversion from maintenance calcineurin inhibitor to belatacept. Results: Both patients experienced improvement in renal function following conversion. Conclusions: These results suggest that patients with more severe degrees of allograft impairment may benefit from conversion of maintenance calcineurin inhibitor to belatacept-based immunosuppression. Larger, randomized studies are warranted to evaluate the impact of such an approach.
Matching for the MICA-129 polymorphism is beneficial in unrelated hematopoietic stem cell transplantation
Authors: Fuerst Daniel , Neuchel Christine , Niederwieser Dietger , Bunjes Donald , Gramatzki Martin , Wagner Eva , Wulf Gerald , Glass Bertram , Pfreundschuh Michael , Einsele Hermann , Arnold Renate , Stuhler Gernot , Schaefer-Eckart Kerstin , Freitag Sebastian , Casper Jochen , Kaufmann Martin , Wattad Mohammed , Hertenstein Bernd , Klein Stefan , Ringhoffer Mark , Mytilineos Daphne , Tsamadou Chrysanthi , Mueller Carlheinz , Schrezenmeier Hubert , Mytilineos Joannis 
Published: November 2016

Key Points
MICA-129 matching improves survival in uHSCT. MICA-129 mismatches were observed in 6.7% of all transplant patients.
Loss of Functional Osteoprotegerin: More Than a Skeletal Problem
Authors: Grasemann Corinna , Unger Nicole , Hövel Matthias , Arweiler-Harbeck Diana , Herrmann Ralf , Schündeln Michael M. , Müller Oliver , Schweiger Bernd , Lausch Ekkehart , Meissner Thomas , Kiewert Cordula , Hauffa Berthold P. , Shaw Nick J. 
Published: November 2016

Abstract

Introduction:
Juvenile Paget’s disease (JPD), an ultra-rare, debilitating bone disease due to loss of functional osteoprotegerin (OPG), is caused by recessive mutations in TNFRFSF11B. A genotype–phenotype correlation spanning from mild to very severe forms is described.

Aim:
This study aimed to describe the complexity of the human phenotype of OPG deficiency in more detail and to investigate heterozygous mutation carriers for clinical signs of JPD.

Patients:
We investigated 3 children with JPD from families of Turkish, German, and Pakistani descent and 19 family members (14 heterozygous).

Results:
A new disease-causing 4 bp-duplication in exon 1 was detected in the German patient, and a microdeletion including TNFRFSF11B in the Pakistani patient. Skeletal abnormalities in all affected children included bowing deformities and fractures, contractures, short stature and skull involvement. Complex malformation of the inner ear and vestibular structures (2 patients) resulted in early deafness. Patients were found to be growth hormone deficient (2), displayed nephrocalcinosis (1), and gross motor (3) and mental (1) retardation. Heterozygous family members displayed low OPG levels (12), elevated bone turnover markers (7), and osteopenia (6). Short stature (1), visual impairment (2), and hearing impairment (1) were also present.

Conclusion:
Diminished OPG levels cause complex changes affecting multiple organ systems, including pituitary function, in children with JPD and may cause osteopenia in heterozygous family members. Diagnostic and therapeutic measures should aim to address the complex phenotype.
Inappropriate expression of the translation elongation factor 1A disrupts genome stability and metabolism
Authors: Tarrant Daniel J. , Stirpe Mariarita , Rowe Michelle , Howard Mark J. , von der Haar Tobias , Gourlay Campbell W. 
Published: November 2016

ABSTRACT
The translation elongation factor eEF1A is one of the most abundant proteins found within cells, and its role within protein synthesis is well documented. Levels of eEF1A are tightly controlled, with inappropriate expression linked to oncogenesis. However, the mechanisms by which increased eEF1A expression alters cell behaviour are unknown. Our analyses in yeast suggest that elevation of eEF1A levels leads to stabilisation of the spindle pole body and changes in nuclear organisation. Elevation of the eEF1A2 isoform also leads to altered nuclear morphology in cultured human cells, suggesting a conserved role in maintaining genome stability. Gene expression and metabolomic analyses reveal that the level of eEF1A is crucial for the maintenance of metabolism and amino acid levels in yeast, most likely because of its role in the control of vacuole function. Increased eEF1A2 levels trigger lysosome biogenesis in cultured human cells, also suggesting a conserved role within metabolic control mechanisms. Taken together, our data suggest that the control of eEF1A levels is important for the maintenance of a number of cell functions beyond translation and that its de-regulation might contribute to its oncogenic properties.
RHO binding to FAM65A regulates Golgi reorientation during cell migration
Authors: Mardakheh Faraz K. , Self Annette , Marshall Christopher J. 
Published: November 2016

ABSTRACT
Directional cell migration involves reorientation of the secretory machinery. However, the molecular mechanisms that control this reorientation are not well characterised. Here, we identify a new Rho effector protein, named FAM65A, which binds to active RHOA, RHOB and RHOC. FAM65A links RHO proteins to Golgi-localising cerebral cavernous malformation-3 protein (CCM3; also known as PDCD10) and its interacting proteins mammalian STE20-like protein kinases 3 and 4 (MST3 and MST4; also known as STK24 and STK26, respectively). Binding of active RHO proteins to FAM65A does not affect the kinase activity of MSTs but results in their relocation from the Golgi in a CCM3-dependent manner. This relocation is crucial for reorientation of the Golgi towards the leading edge and subsequent directional cell migration. Our results reveal a previously unidentified pathway downstream of RHO that regulates the polarity of migrating cells through Golgi reorientation in a FAM65A-, CCM3- and MST3- and MST4-dependent manner.
Reforming environmental law: the democratic case for market incentives
Authors: Ackerman Bruce A. , Stewart Richard B. 
Published: November 2016

In this article, the environmental law is discussed under the democratic and market perspectives, in order to present to the reader that it is possible to have more efficiency to the administrative processes of this scenario, and that the market incentives, when properly used, can save billions of dollars each year, helping to balance the budget and the system of pollution regulation. Neste artigo, a reforma do direito ambiental é discutida à luz dos valores democráticos e de mercado, no intuito de mostrar ao leitor que é possível trazer mais eficiência aos processos administrativos presentes neste cenário, e que os incentivos de mercado, quando usados de forma criativa, podem economizar bilhões de dólares por ano, auxiliando no controle do orçamento e no sistema de regulação da poluição.
Empresas estatais e parcerias institucionais
Authors: Marques Neto Floriano de Azevedo , De Palma Juliana Bonacorsi 
Published: November 2016

O presente artigo aborda o tema das parcerias nas empresas estatais considerando o regime jurídico das estatais e o potencial desses instrumentos de desenvolver a governança nas estatais, bem como propiciar a inovação tecnológica a partir da associação público-privada. Para tanto, o artigo parte da análise do regime jurídico-constitucional das empresas estatais, cujas recentes emendas constitucionais terminaram por viabilizar parcerias estratégicas das empresas estatais sem importar em burla ao dever de licitar. Na sequência, analisa a formalização fundamental das parcerias envolvendo as empresas estatais e os tipos de parcerias de que elas podem se valer para satisfazer suas finalidades públicas. Casos concretos exemplificam as nossas análises. Ao final, apresentamos considerações sobre o cenário de mudança do direito público e seu impacto sobre as empresas estatais. This paper tackles the issue of state-owned companies’ partnerships considering their regulation, the potential of governance increment, as well as how public-private associations can foster innovation. First, we analyze the constitutional norms applicable to state-owned companies and the recent amendments, which enabled strategic partnerships. This constitutional change does not imply bid rigging. Second, we study how the different types of the state-owned companies’ partnerships and their correspondent formalization. Cases exemplify the analysis hereby developed. In the end, we discuss hoe the current changes in Brazilian public law may impact the regulation of the state-owned companies.
Resource Allocation Under Demand Uncertainty and Private Information
Authors: Belloni Alexandre , Lopomo Giuseppe , Wang Shouqiang 
Published: November 2016

We study the effect of multilateral private information on the efficiency of markets where capacity-constrained upstream agents supply a resource to downstream entities facing uncertain end-demands. We analyze two models: a “pooling system,” in which a single downstream principal pools a resource from multiple upstream agents; and a “distribution system,” in which one upstream principal allocates a resource across multiple downstream agents. We show that the presence of multilateral private information does not hinder efficiency in the pooling system. In contrast, in the distribution system, the quantities allocated to downstream agents can exceed, as well as fall short of, their first-best levels. These results shed light on the recently improved performance of U.S. agricultural produce market, and the observed episodes of shortages/oversupplies in flu vaccine and other seasonal markets. This paper was accepted by Manel Baucells, decision analysis.
A Novel Protein Glycan–Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality
Authors: McGarrah Robert W , Kelly Jacob P , Craig Damian M , Haynes Carol , Jessee Ryan C , Huffman Kim M , Kraus William E , Shah Svati H 
Published: November 2016

Abstract

BACKGROUND
Evidence suggests that systemic inflammation may adversely impact HDL function. In this study we sought to evaluate the independent and incremental predictive performance of GlycA—a novel serum inflammatory biomarker that is an aggregate measure of enzymatically glycosylated acute phase proteins—and HDL subclasses on adverse events in a retrospective observational study of a secondary prevention population and to understand a priori defined potential interactions between GlycA and HDL subclasses.

METHODS
GlycA and HDL subclasses were measured using proton nuclear magnetic resonance spectroscopy in 7617 individuals in the CATHGEN (CATHeterization GENetics) cardiac catheterization biorepository.

RESULTS
GlycA was associated with presence [odds ratio (OR) 1.07 (1.02–1.13), P = 0.01] and extent [OR 1.08 (1.03, 1.12) P &lt; 0.0005] of coronary artery disease and with all-cause mortality [hazard ratio (HR) 1.34 (1.29–1.39), P &lt; 0.0001], cardiovascular mortality [1.37 (1.30–1.45), P &lt; 0.0001] and noncardiovascular mortality [1.46 (1.39–1.54) P &lt; 0.0001] in models adjusted for 10 cardiovascular risk factors. GlycA and smaller HDL subclasses had independent but opposite effects on mortality risk prediction, with smaller HDL subclasses being protective [HR 0.69 (0.66–0.72), P &lt; 0.0001]. There was an interaction between GlycA and smaller HDL subclasses—increasing GlycA concentrations attenuated the inverse association of smaller HDL subclasses with mortality. Adding GlycA and smaller HDL subclasses into the GRACE (Global Registry of Acute Coronary Events) and Framingham Heart Study Risk Scores improved mortality risk prediction, discrimination and reclassification.

CONCLUSIONS
These findings highlight the interaction of systemic inflammation and HDL with clinical outcomes and may increase precision for clinical risk assessment in secondary prevention populations.
Sentidos no texto - uma análise de “Neologismo”, de Bandeira
Authors: Guimarães Eduardo 
Published: November 2016

O ARTIGO ANALISA, A PARTIR DA POSIÇÃO DA SEMÂNTICA DA ENUNCIAÇÃO O POEMA 'NEOLOGISMO" DE BANDEIRA OBSERVANDO ALGUNS RECORTES FUNDAMENTAIS DE LEITURA:1.A enunciação decisiva: “Teadoro, Teodora” 2.A articulação dos enunciados e a textualidade; 3. As orientações do dizer; 4. A Cena enunciativa.Esta análise permite levar a interessante conclusões sobre o espaço de enunciação e a divisão do locutor, assim como a uma interessante caracterização do lirismo do poema
Oral motor intervention accelerates time to full oral feeding and discharge
Authors: Osman Atiat , Ahmed Eman , Mohamed Hend , Hassanein Farok , Brandon Debra 
Published: November 2016

Background: A Survival rate in early preterm infants has increased over the last 30 years, but many of these infants have medical and developmental problems. Difficulty with feeding and poor nutrition complications are common, which contribute to their readmission and morbidity.Objective: To purpose of this study was to assess whether an oral motor stimulation intervention can decrease the time to achieve full oral feeding and shorten the length of hospitalization in preterm infants.Design and Methods: Seventy-five preterm infants born at 30 to ≤ 32 weeks gestational age were randomly assigned to three groups to assess intervention effects. Two groups received the intervention once per day with varying different intervention doses across time, while the control group received a sham intervention.Results: The time needed to reach full oral feeding was significantly different among groups (P <0.0001). Infants who received the intervention from initiation of tube feedings until full oral feeding (high dose) gained full oral feedings and were discharged from the hospital earlier than the low dose and control groups (P = 0.0001). Infants in the high dose group were discharged 6 days earlier than controls and 4 days earlier than the low dose group.Conclusion: Oral motor stimulation intervention accelerated the time to full oral feeding and decreased the length of hospital stay.
Geomorphometry of the Glacial Cirques in Zardkuh Mountain, Iran
Authors: Ahmadabadi Ali , Sargsyan Varduhi 
Published: November 2016

Abstract
Cirques as one of the glacial erosional forms are suitable indicators to recognize the environmental conditions of the Quaternary period. Therefore, considering the importance of glacial cirque landforms, identifying and mapping the distribution of the circus with their shape features meets the need of environmental science, especially geomorphology. In this paper, in order to identify the quantitative features of cirques in Zardkuh region, the second derivatives, including second-degree curvature of the plan, profile and general curvature along with slope as a primarily derivative were used from geomorphometry indices. To this end, 20 meter resolution digital elevation model was generated from 1: 25,000 topographic map which was used in the geomorphometric analysis. The result shows that secondary derivatives had higher performance in identifying the feature shapes of glacial cirques. Likewise, the plan curvature Index could truly present the headwall around the circus as well as profile curvature clearly showed the avalanche path. In conclusion, it seems that the second derivative indicators, including curvature’s family, have high capability to extract and detect different natural shapes from digital elevation data.
Lower limb loading during knee up in step aerobics: a pilot study
Authors: Błażkiewicz Michalina , Wiszomirska Ida , Kaczmarczyk Katarzyna , Brzuszkiewicz-Kuźmicka Grażyna , Wit Andrzej 
Published: November 2016

Summary
Study aim: Step aerobics is a form of aerobic power distinguished from other types of aerobic exercise by its use of an elevated platform. The purpose of this study was to examine how the aerobic exercise “knee up” affects kinematic and kinetic parameters and, above all, the length of the muscle contractions.

Material and methods: The study analysed ten female fitness instructors with at least six years of experience. The task consisted in the knee up move performed using a 15 cm step and music with the beat frequency of 148 BPM. Kinematic and kinetic parameters were recorded using the Vicon system synchronized with two Kistler force plates. OpenSim software was used for calculation of the length of involved muscles.

Results: Ranges in angles and torques suggest that the location that is the most prone to injuries and overtraining is the knee joint, followed by the hip and ankle joints. Greater values of the vertical component of ground reaction forces were observed during stepping down, which suggests greater load to the joints. The greatest work in the move analysed in this study was performed by the sartorius muscle and the tensor fasciae latae muscle.

Conclusions: Despite the benefits that have been demonstrated when step classes are structured correctly and adapted to the participants, further research is needed concerning biomechanical load, exercise prescription, and injury prevention.
Text and Image in Translation
Authors: Yablonsky Milena 
Published: November 2016

Abstract
The primary objective of the following paper is the analysis of selected issues related to the translation of comic books. The paper aims at investigating the relationships between the text and the image and their implications in the process of translation. It reflects on the status of the translation of comics/graphic novels - a still largely unexploited area within Translation Studies and briefly presents a definition and specificity of the genre. Moreover, it discusses Jakobson’s (1971) tripartite distinction into interlinguistic, intralinguistic and intersemiotic translation. The paper concludes with the analysis of certain issues associated with the Polish translation of V like Vendetta by Alan Moore, a text that is copious with intertextual and cultural references.
The Influence of the Load Model and other
Parameters on the Dynamic Behavior of
Curved-in-Plane Bridges
Authors: Raftoyiannis Ioannis G. , Michaltsos George T. 
Published: November 2016

Abstract
This paper deals with the dynamic behavior of
curved-in-plane bridges where the effect of the bridge curvature
radius, the moving load (vehicle) speed, the truck
cant angle, the deck surface conditions and, mainly, the response
accuracy depending on the vehicle model used are
investigated. Besides the above parameters, the influence
of several loading models is studied as well, especially the
models of a concentrated load, a damped mass-load, a sequence
of two concentrated loads and a real vehicle aswell
as a damped vehicle,where its width is taken into account.
A 3-DOF model is considered for the analysis of the bridge,
while the theoretical formulation is based on a continuum
approach, which has been widely used in the literature to
analyze such bridges.
Petrographic composition of lignite from the Szczerców deposit, Polish Lowlands
Authors: Pawelec Sandra , Bielowicz Barbara 
Published: November 2016

Abstract
Macroscopic and microscopic composition of lignite from the Szczerców deposit belonging to the Bełchatów Lignite Mine (Polish Lowlands) has been examined. The macroscopic composition was determined according to the newest lithological classification of humic coal. On this basis, it has been shown that the main lithotypes occurring in the Szczerców deposit are the detritic and xylodetritic lignites.
The petrographic composition of the investigated lignite was determined microscopically for 11 samples. The examined lignite is predominantly composed of macerals from the huminite group. It is in the range from 75.2 to 86%, including atrinite (23.1–40.7%, averaging 28.9%) and densinite (18.2–41.4 %, averaging 24.9%). It also demonstrated that the statistical variability of the macerals content from the huminite group in the studied lignite is very weak in all samples. In addition, the random reflectance of ulminite was measured traditionally. The results, ranging from 0.247 to 0.282%, with the maximum permissible standard deviation < 0.07, were achieved for all analysed lignite samples.
Age and origin of fluorapatite-rich dyke from Baranec Mt. (Tatra Mts., Western Carpathians): a key to understanding of the post-orogenic processes and element mobility
Authors: Gawęda Aleksandra , Szopa Krzysztof , Chew David , Klötzli Urs , Müller Axel , Sikorska Magdalena , Pyka Paulina 
Published: November 2016

AbstractOn the southeastern slope of the Baranec Mount in the Western Tatra Mountains (Slovakia) an apatite-rich pegmatite-like segregation was found in the subvertical fault zone cutting metapelitic rocks. Two zones: felsic (F) and mafic (M) were found, differing in mineral assemblages and consequently in chemistry. Fluorapatite crystals yield a LA-ICP-MS U-Pb age of 328.6 ± 2.4 Ma. A temperature decrease from 634 °C to 454 °C at a pressure around 500 to 400 MPa with oxygen fugacity increasing during crystallization are the possible conditions for formation of the pegmatite-like segregation, while secondary alterations took place in the temperature range of 340 – 320 °C. The Sr-Nd isotope composition of both apatite and whole rock point toward a crustal origin of the dike in question, suggesting partial melting of (P, F, H2O)-rich metasedimentary rocks during prolonged decompression of the Tatra Massif. The original partial melt (felsic component) was mixed with an external (F, H2O)-rich fluid, carrying Fe and Mg fluxed from more mafic metapelites and crystallizing as biotite and epidote in the mafic component of the dyke.