bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation or Causation? A Case Report of Endometriosis within a Caesarean Scar Defect
Authors: Lawless Anna , To Valerie , Lam Alan 
Published: February 2017

Introduction Caesarean scar defect is a well-recognised complication of caesarean section. It can cause secondary infertility, although the mechanism is still poorly understood. Case description We present the case of a patient diagnosed with a caesarean scar defect on transvaginal ultrasound, following referral for secondary infertility. During laparoscopy performed with concurrent hysteroscopy, the caesarean scar defect was found to be continuous with an endometriotic nodule in the uterovesical peritoneum. This was excised along with other endometriosis implants. Histopathology of the resected defect also showed endometriosis. Conclusions This case illustrates a possible link between caesarean scar defect and endometriosis, and highlights the benefit of laparoscopy to allow additional treatment of coexisting pathology, such as endometriosis, that could also contribute to infertility.
Complex cystine kidney stones treated with combined robot-assisted laparoscopic pyelolithotomy and intraoperative renoscopy
Authors: Meggiato Luca , Cattaneo Francesco , Zattoni Fabio , Dal Moro Fabrizio , Beltrami Paolo , Zattoni Filiberto 
Published: February 2017

Introduction: Cystinuria, a rare autosomal recessive disease characterized by a defect in cystine renal reabsorption, can often determine complex cystine renal calculi, leading to important complications such as urinary obstruction, urinary infections, and impaired kidney function. Complex kidney stones can have a difficult management and can be very arduous to treat. Case description: We present the case of a 20-year-old Jeowah’s witness woman with complex cystine renal stones treated with combined robot-assisted laparoscopic pyelolithotomy and intraoperative renoscopy. Conclusions: The combination of robot-assisted laparoscopic pyelolithotomy and intraoperative renoscopy can be useful to achieve an immediate high stone clearance rate also in complex renal stones. This combined technique could be indicated to minimize intraoperative bleeding. Moreover, it can also be used in pediatric cases or when there is no ureteral compliance. However, this strategy can be performed only in hospital referral centers by expert surgeons.
Appropriateness of Plasma Transfusion: A College of American Pathologists Q-Probes Study of Guidelines, Waste, and Serious Adverse Events
Authors: Alcorn Kirsten , Ramsey Glenn , Souers Rhona , Lehman Christopher M. 
Published: February 2017

Context.—Plasma transfusion guidelines support patient care and safety, management of product wastage, and compliance; yet, there is little information across multiple institutions about use of and adherence to plasma transfusion guidelines.Objective.—To survey multiple institutions regarding their plasma transfusion guidelines and compliance, plasma wastage rates, and incidence of transfusion reactions associated with plasma transfusion.Design.—The College of American Pathologists Q-Probes model was used to collect data from 89 participating institutions. Each site was asked to provide data relevant to its most recent 40 adult patient plasma transfusion episodes, and complete a questionnaire regarding plasma transfusion guidelines, utilization and wastage of plasma, and transfusion reactions related to plasma transfusion.Results.—The participating institutions reported a total of 3383 evaluable plasma transfusion episodes with transfusion of 9060 units of plasma. Compliance with institution-specific guidelines was seen in 3018 events (89%). Pretransfusion and posttransfusion coagulation testing was done in 3281 (97%) and 3043 (90%) of these episodes, respectively. Inappropriate criteria were noted for more than 100 transfusion episodes. Thirty-two plasma transfusion episodes (1%) were associated with a transfusion reaction. Serious and fatal reactions were reported. Median plasma wastage rate for the year preceding the study was 4.5%.Conclusions.—Most participating institutions are compliant with plasma transfusion guidelines based on published references, supported by appropriate testing. With transfusions for indications that lack evidence of efficacy and incidence of transfusion reactions, there is an ongoing role for transfusion service leaders to continue to update and monitor plasma transfusion practices.
ГРАДСКИ ТУРИЗАМ КАО РАЗВОЈНА ШАНСА ТУРИЗМА ГРАДА КРАГУЈЕВЦА
Authors: Podovac Milena 
Published: February 2017

The subject of analysis is the urban tourism as an important segment of the tourist offer. The paper analyzes the potential for urban tourism development development of Kragujevac. Based on the analysis of resources, which are essential for the development of urban tourism, in the conclusion are derived guidelines for improving the image of the city of Kragujevac as a tourist destination.
Rhetorical evolution of oppositional discourse in French academic writing. Oppositional discourse in academic writing
Authors: Salager-Meyer Françoise 
Published: February 2017

We here analyze the quantitative and qualitative evolution of academic conflict (AC) in a corpus of 90 medical articles published between 1810 and 1995. The linguistic means expressing AC were recorded in each paper and classified according to whether they expressed a direct or an indirect conflict. The frequency of each category of AC was first recorded in each paper, and then calculated per 20–year periods. Our results were analyzed using Chi–square tests. In the whole corpus, direct AC were more frequent than indirect ones (p = .0001). When analyzed per 20–year periods, our quantitative results allowed us to divide the 185 years studied into 2 distinct periods, the cutting–off point being the 1910’s when the frequency of indirect AC started a slow but continuous ascent. In each Block direct AC outnumbered indirect ones (p =.0001), but indirect AC were more frequent in Block B than in Block A (p = .039). A qualitative analysis of the AC recorded revealed that both 19th and 20th century AC were expressed in a personal, polemical and authoritarian manner, although the confrontational stance of late 20th century AC tends to be mitigated either by means of hedging expressions or through the shifting of person to object thematization. We conclude that when formulating their professional disagreement, French-speaking scientists have always been authoritative, categorical, direct and personal, although the tone of voice of confrontations tends to be more “low key” as we approach the turn of the 21st century.
Hermitian symmetric spaces of tube type and multivariate Meixner-Pollaczek polynomials
Authors: Faraut Jacques , Wakayama Masato 
Published: February 2017

Harmonic analysis on Hermitian symmetric spaces of tube type is a natural framework for introducing multivariate Meixner-Pollaczek polynomials. Their main properties are established in this setting: orthogonality, generating and determinantal formulae, difference equations. For proving these properties we use the composition of the following transformations: Cayley transform, Laplace transform, and spherical Fourier transform associated to Hermitian symmetric spaces of tube type. In particular the difference equation for the multivariate Meixner-Pollaczek polynomials is obtained from an Euler type equation on a bounded symmetric domain.
Mild singular potentials as effective Laplacians in narrow strips
Authors: De Oliveira César R. , Verri Alessandra A. 
Published: February 2017

We propose to obtain information on one-dimensional Schrödinger operators on bounded intervals by approaching them as effective operators of the Laplacian in thin planar strips. Here we develop this idea to get spectral knowledge of some mild singular potentials with Dirichlet boundary conditions. Special preparations, including a result on perturbations of quadratic forms, are included as well.
Lobe‐cleft instability in the buoyant gravity current generated by estuarine outflow
Authors: Horner‐Devine Alexander R. , Chickadel C. Chris 
Published: February 2017

AbstractGravity currents represent a broad class of geophysical flows including turbidity currents, powder avalanches, pyroclastic flows, sea breeze fronts, haboobs, and river plumes. A defining feature in many gravity currents is the formation of three‐dimensional lobes and clefts along the front and researchers have sought to understand these ubiquitous geophysical structures for decades. The prevailing explanation is based largely on early laboratory and numerical model experiments at much smaller scales, which concluded that lobes and clefts are generated due to hydrostatic instability exclusively in currents propagating over a nonslip boundary. Recent studies suggest that frontal dynamics change as the flow scale increases, but no measurements have been made that sufficiently resolve the flow structure in full‐scale geophysical flows. Here we use thermal infrared and acoustic imaging of a river plume to reveal the three‐dimensional structure of lobes and clefts formed in a geophysical gravity current front. The observed lobes and clefts are generated at the front in the absence of a nonslip boundary, contradicting the prevailing explanation. The observed flow structure is consistent with an alternative formation mechanism, which predicts that the lobe scale is inherited from subsurface vortex structures.
Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis
Authors: Chen Xiqun , Feng Danielle , Schwarzschild Michael A. , Gao Xiang 
Published: February 2017

AbstractSeveral studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair‐associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta‐analysis of six publications on red hair, MC1R, and Parkinson's disease. We found that red hair (pooled odds ratios = 1.68, 95% confidence intervals: 1.07, 2.64) and p.R151C (pooled odds ratios = 1.10, 95% confidence intervals: 1.00, 1.21), but not p.R160W, were associated with greater risk for Parkinson's disease. Our results support potential roles of pigmentation and its key regulator MC1R in the pathogenesis of Parkinson's disease.
Lipofibromatous hamartoma of the median nerve – A case report
Authors: Palmer Elliott J. , Sritharan Aran R. , Sampson Matthew J. 
Published: February 2017

AbstractLipofibromatous hamartoma (LFH) is a rare benign slow growing fibrofatty tumour. It comprises a neurogenic mass of non‐inflamed peripheral nerve bundles surrounded and separated by mature fat. LFH has a tendency for the median nerve; however, involvement of the brachial plexus, ulnar, radial, peroneal and plantar nerves has also been described. Patients typically experience pain, with or without sensory and motor deficits. The diagnosis of LFH is highly supported by imaging findings. Ultrasound is increasingly being recognised as a useful tool in aiding diagnosis.
Lattice‐Matched Epitaxial Growth of Organic Heterostructures for Integrated Optoelectronic Application
Authors: Zhang Yi , Liao Qing , Wang Xinguo , Yao Jiannian , Fu Hongbing 
Published: February 2017

AbstractDevelopment of nanowire photonics requires integration of different nanowire components into highly ordered functional heterostructures. Herein, we report a sequential self‐assembly of binary molecular components into branched nanowire heterostructures (BNHs) via lattice‐matched epitaxial growth, in which the microribbon backbone of 2,5‐Bis(5‐tert‐butyl‐2‐benzoxazolyl)thiophene (BBOT) functions as blue‐emitting microlaser source to pump the nanowire branches of BODIPY. By constructing Au electrodes on both branch sides and measuring the photocurrent in them, we successfully realize the integration of an organic laser and a power meter in a single device. This work provides a new insight into the integration of 1D organic nanostructures into BNHs for realizing organic multifunctional photonic devices.
Cobalt complexes based on hyperbranched salicylaldimine ligands as catalyst precursors for ethylene oligomerization
Authors: Li Cuiqin , Wang Fengfeng , Lin Zhiyu , Zhang Na , Wang Jun 
Published: February 2017

Three hyperbranched salicylaldimine ligands with tetradecyl as core, with hexadecyl as core and with octadecyl as core were synthesized in good yields. These ligands were reacted with cobalt chloride hexahydrate to form three complexes (C1–C3). The compounds were characterized using Fourier transform infrared, 1H NMR, mass and UV spectroscopies and thermogravimetric and differential thermal analyses. The catalytic properties of the hyperbranched cobalt complexes were evaluated for ethylene oligomerization. The effects of solvent and reaction parameters (Al/Co molar ratio, temperature and reaction pressure) on ethylene oligomerization were studied using the cobalt complex C3 as pre‐catalyst and methylaluminoxane (MAO) as co‐catalyst. Under these conditions ([Co] = 5 μmol, Al/Co = 500, 25 °C, 0.5 MPa ethylene, 30 min), the catalytic activity of complex C3 in toluene was 1.85 × 105 g (mol Co)−1 h−1 and the selectivity for C8+ oligomers was 55.72%. The complex structure also had a significant influence on both the catalytic activity and selectivity. All three cobalt complexes, activated with MAO, showed moderate activities towards ethylene oligomerization and the activity of cobalt complex C1 was up to 1.99 × 105 g (mol Co)−1 h−1. The kinds of metal center of complexes (cobalt complex C1 and nickel complex with tetradecyl as core) and their catalytic properties were investigated in detail under the same conditions.
Silole Silylene Route to NHC‐Stabilized Fused 1‐Silabicycles and 1,1′‐Spirobisiloles
Authors: Li Tianhao , Zhang Jianying , Cui Chunming 
Published: February 2017

AbstractThe reaction of an NHC‐stabilized silole silylene (1, 1‐silacyclopentadienylidene) with one equivalent of internal acetylenes resulted in the formation of NHC‐stabilized 1‐silabicyclo[3.2.0]hepta‐1,3,6‐trienes, which subsequently reacted with one equivalent of the acetylene to yield an aryl‐substituted 1,1′‐spirobisilole (SBS). The SBSs can also be prepared by reaction of the NHC‐stabilized silole silylene 1 with two equivalents of the acetylenes in good yields. The electronic structures of these SBSs have been studied by UV/Vis and emission spectroscopy, as well as DFT calculations.
A Packet Loss Tolerant Rendezvous Algorithm for Wireless Networked Robot Systems
Authors:  Manfredi Sabato , Natalizio Enrico , Pascariello Claudio , Zema Nicola Roberto 
Published: February 2017

AbstractThis paper studies the coordination problem for a wireless networked robot (WNR) system. The objective is to drive the robots to keep a desired formation through local exchange of information. Nevertheless, packet losses may occur during communications among robots, thus preventing the system to reach its specific target. Specifically, the effects of an unreliable channel on the WNR performance are analyzed by considering the simulation of a corrective consensus algorithm into a network simulator. The use of a packet‐loss‐tolerant protocol is suggested to cope with heavy communication disruption. Network Simulator (NS‐3) simulation results validate the effectiveness of the proposed approach.
Determination of the coenzyme Q10 status in a large Caucasian study population
Authors: Onur Simone , Niklowitz Petra , Fischer Alexandra , Jacobs Gunnar , Lieb Wolfgang , Laudes Matthias , Menke Thomas , Döring Frank 
Published: February 2017

AbstractCoenzyme Q10 (CoQ10) exists in a reduced (ubiquinol) and an oxidized (ubiquinone) form in all human tissues and functions, amongst others, in the respiratory chain, redox‐cycles, and gene expression. As the status of CoQ10 is an important risk factor for several diseases, here we determined the CoQ10 status (ubiquinol, ubiquinone) in a large Caucasian study population (n = 1,911). The study population covers a wide age range (age: 18–83 years, 43.4% men), has information available on more than 10 measured clinical phenotypes, more than 30 diseases (presence vs. absence), about 30 biomarkers, and comprehensive genetic information including whole‐genome SNP typing (>891,000 SNPs). The major aim of this long‐term resource in CoQ10 research is the comprehensive analysis of the CoQ10 status with respect to integrated health parameters (i.e., fat metabolism, inflammation), disease‐related biomarkers (i.e., liver enzymes, marker for heart failure), common diseases (i.e., neuropathy, myocardial infarction), and genetic risk in humans. Based on disease status, biomarkers, and genetic variants, our cohort is also useful to perform Mendelian randomisation approaches. In conclusion, the present study population is a promising resource to gain deeper insight into CoQ10 status in human health and disease. © 2015 BioFactors, 41(4):211–221, 2015
Unique features of human cathelicidinLL‐37
Authors: Bandurska Katarzyna , Berdowska Agnieszka , Barczyńska‐Felusiak Renata , Krupa Piotr 
Published: February 2017

AbstractCathelicidins are antimicrobial peptides produced by humans and animals in response to various pathogenic microbes. This review intends to provide a brief overview of the expression, structure, properties and function of human cathelicidin LL‐37 which may be a therapeutic agent against a variety of bacterial and viral diseases, cancers, and hard‐to‐heal wounds. Cathelicidins act as a primary defense against bacteria and other pathogens in the case of inflammation. They are able to kill bacteria and fungi, inhibit and destroy bacterial biofilms, and possess antiviral and antiparasitics properties. They can also play a role in angiogenesis, wound healing, and the regulation of apoptosis. The host defense peptide LL‐37 has emerged as a novel modulator of tumor growth and metastasis in carcinogenesis of various types of cancers. LL‐37 is an antimicrobial peptide able of inducing various effects. It acts as an anti‐ and pro‐ inflammatory factor. Cathelicidins are able to directly and selectively destroy membranes of various microbes and cancer cells, but they do not attack normal cells. The role of cathelicidins in cancer is double‐sided. They play an important role in killing cancer cells and may provide a new possibility for the development of cancer therapeutics. However, they also can participate in carcinogenesis. Due to its activity spectrum LL‐37 could be applied in pharmacotherapy. Cathelicidin peptides could serve as a template for the development of modern anti‐microbial and anti‐viral drugs. LL‐37 is an excellent candidate to develop into therapeutics for infected wounds. © 2015 BioFactors, 41(5):289–300, 2015
Cofilin phosphorylation is elevated after F‐actin disassembly induced by Rac1 depletion
Authors: Liu Linna , Li Jing , Zhang Liwang , Zhang Feng , Zhang Rong , Chen Xiang , Brakebusch Cord , Wang Zhipeng , Liu Xinyou 
Published: February 2017

AbstractCytoskeletal reorganization is essential to keratinocyte function. Rac1 regulates cytoskeletal reorganization through signaling pathways such as the cofilin cascade. Cofilin severs actin filaments after activation by dephosphorylation. Rac1 was knocked out in mouse keratinocytes and it was found that actin filaments disassembled. In the epidermis of mice in which Rac1 was knocked out only in keratinocytes, cofilin phosphorylation was aberrantly elevated, corresponding to repression of the phosphatase slingshot1 (SSH1). These effects were independent of the signaling pathways for p21‐activated kinase/LIM kinase (Pak/LIMK), protein kinase C, or protein kinase D or generation of reactive oxygen species. Similarly, when actin polymerization was specifically inhibited or Rac1 was knocked down, cofilin phosphorylation was enhanced and SSH1 was repressed. Repression of SSH1 partially blocked actin depolymerization induced by Rac1 depletion. Therefore, aberrant cofilin phosphorylation that induces actin polymerization might be a consequence of actin disassembly induced by the absence of Rac1. © 2015 BioFactors, 41(5):352–359, 2015
Lycopene powers the inhibition of glycation‐induced diabetic nephropathy: A novel approach to halt the AGE‐RAGE axis menace
Authors: Tabrez Shams , Al‐Shali Khalid Zaki , Ahmad Saheem 
Published: February 2017

AbstractThere are accumulating evidences suggesting that interaction between advanced glycation end products (AGEs) and their receptors (RAGEs) induces oxidative stress and subsequently encourages inflammatory reactions, thereby resulting in progressive alteration in renal architecture and function. Interventions that reduce the tissue burden of AGEs have yielded significant positive results in inhibiting the progression of diabetic complications such as diabetic nephropathy. Lycopene, a carotenoid, plays an important role in protection against oxidative stress and hence might prove an efficient antiglycating agent. Current study investigates the effect of lycopene in downregulating the menace caused by ribose‐induced glycation both in vitro and in vivo. We observed that treatment with lycopene decelerated the ribose induced AGE formation in HK‐2 cells and in rat kidneys thereby downregulating the expression RAGE. HK‐2 cells with decreased levels of RAGE showed a decline in nuclear factor κB (NFκB) and matrix metalloproteinase 2 (MMP 2) expressions. Administration of ribose not only induced hyperglycemia in Wistar rats but also developed diabetic nephropathy (DN). However, lycopene was found effective in relieving the biochemical symptoms of DN. Thus lycopene provides protection against development of diabetic nephropathy and ameliorates renal function by halting AGE‐RAGE axis. © 2015 BioFactors, 41(5):372–381, 2015.
Piperine alleviates osteoclast formation through the p38/c‐Fos/NFATc1 signaling axis
Authors: Deepak Vishwa , Kruger Marlena C. , Joubert Annie , Coetzee Magdalena 
Published: February 2017

Abstract.Increased bone fracture is one of the health risk factors in patients with bone loss related disorders such as osteoporosis and breast cancer metastasis to bone. Over activity of osteoclasts leads to uncoupling of bone remodeling favoring bone loss over bone formation. Receptor activator of nuclear factor‐κβ ligand (RANKL) triggers the differentiation pathway leading to multinucleated osteoclast formation. Modulation of RANKL or its downstream signaling pathways involved in osteoclast formation is of significant interest in the development of anti‐resorptive agents. In this study, the effects of piperine, an alkaloid present in Piper nigrum L. on osteoclast formation was investigated. Piperine inhibited tartrate‐resistant acid phosphatase‐positive multinucleated osteoclast formation in murine RAW264.7 macrophages and human CD14+ monocytes induced by RANKL and breast cancer cells. Piperine attenuated the p38‐mitogen activated protein kinase pathway activation, while the extracellular‐signal‐regulated kinase, c‐Jun N‐terminal kinase, or NF‐κβ pathways downstream of RANKL remained unaffected. Concomitantly, expression of c‐Fos and nuclear factor of activated T‐cells, cytoplasmic 1 (NFATc1), the key transcription factors involved in osteoclastogenesis were remarkably inhibited by piperine. Furthermore, piperine disrupted the actin ring structure and bone resorption, a characteristic hallmark of osteoclasts. Collectively, these results suggested that piperine inhibited osteoclast differentiation by suppressing the p38/NFATc1/c‐Fos signaling axis. © 2015 BioFactors, 41(6):403–413, 2015