bluuebunny/crossref_metadata_2025_split huggingface dataset:
First-Order Model of Free-Jet Hydrodynamic Evolution for Heat Transfer Prediction, Including Nozzle and Flow Rate Effects
Authors: Harnik Ron S. , Haustein Herman D. 
Published: November 2016

Jet impingement flow is known to generate one of the highest single-phase heat transfer rates, with potential for micro-electronics cooling applications. Although free-surface jets have been studied extensively, existing models are either too complex for practical use or do not consider all relevant parameters, such as the impinging jet’s velocity profile. Recently the authors have shown that the stagnation zone heat transfer is dictated by the jet’s centerline velocity upon impingement, and that going between the limiting cases (uniform vs. parabolic profiles, laminar flow) corresponds to a two-fold increase in heat transfer.
In the present study, which is motivated by cooling at micro-scales (predominantly laminar flows), this simplified analysis is extended leading to a first-order analytical approximation, which is valid not only for the limiting cases but over the entire profile range. Thereby, the development of the jet flow both in the nozzle (pipe-type) and subsequently during its flight (before impingement) is incorporated in this model over a broad range of parameters.
For validation of the model, as well as for additional insight into the governing physics, direct numerical simulations were conducted. Through which it is shown that the jet’s velocity profile and its evolution during free “flight” are dependent on the level of the flow’s upstream development in the nozzle, both of which depend on a single self-similar scale: distance travelled normalized by the nozzle diameter and Reynolds number. This one-way coupling requires incorporation of both stages of development for an accurate description, as done in the present model. During pipe-flow, the first-order model employs a more-rapid development rate than during jet-flight (due to the additional pressure-driven flow) — converging to more complex, well-known models, within a few pipe diameters (for Re = 200 to 2300). During flight, the model describes velocity profile relaxation, which is dominated by viscous diffusion and assisted by jet contraction. Jet contraction is dependent on the emerging velocity profile and liquid-vapor surface tension. For most relevant conditions surface tension is negligible, under which the first-order model centerline velocity decay prediction agrees well with both present simulations and previous works.
Thereby, the present work lays the foundation for a simpler, more useable model for predicting heat transfer under an impinging free-surface jet, over a wide range of conditions (various liquids, pipe-type nozzles of different lengths, flow-rates and nozzle-to-plate distances), as part of an ongoing study into micro-jet array heat transfer.
Relationship Between Preseason Training Load and In-Season Availability in Elite Australian Football Players
Authors: Murray Nick B. , Gabbett Tim J. , Townshend Andrew D. 
Published: November 2016

Objectives:To investigate the relationship between the proportion of preseason training sessions completed and load and injury during the ensuing Australian Football League season.Design:Single-cohort, observational study.Methods:Forty-six elite male Australian football players from 1 club participated. Players were divided into 3 equal groups based on the amount of preseason training completed (high [HTL], >85% sessions completed; medium [MTL], 50–85% sessions completed; and low [LTL], <50% sessions completed). Global positioning system (GPS) technology was used to record training and game loads, with all injuries recorded and classified by club medical staff. Differences between groups were analyzed using a 2-way (group × training/competition phase) repeated-measures ANOVA, along with magnitude-based inferences. Injury incidence was expressed as injuries per 1000 h.Results:The HTL and MTL groups completed a greater proportion of in-season training sessions (81.1% and 74.2%) and matches (76.7% and 76.1%) than the LTL (56.9% and 52.7%) group. Total distance and player load were significantly greater during the first half of the in-season period for the HTL (P = .03, ES = 0.88) and MTL (P = .02, ES = 0.93) groups than the LTL group. The relative risk of injury for the LTL group (26.8/1000 h) was 1.9 times greater than that for the HTL group (14.2/1000 h) (χ2 = 3.48, df = 2, P = .17).Conclusions:Completing a greater proportion of preseason training resulted in higher training loads and greater participation in training and competition during the competitive phase of the season.
Quantifying Training Loads in Contemporary Dance
Authors: Jeffries Annie C. , Wallace Lee , Coutts Aaron J. 
Published: November 2016

Purpose:To describe the training demands of contemporary dance and determine the validity of using the session rating of perceived exertion (sRPE) to monitor exercise intensity and training load in this activity. In addition, the authors examined the contribution of training (ie, accelerometry and heart rate) and non-training-related factors (ie, sleep and wellness) to perceived exertion during dance training.Methods:Training load and ActiGraphy for 16 elite amateur contemporary dancers were collected during a 49-d period, using heart-rate monitors, accelerometry, and sRPE. Within-individual correlation analysis was used to determine relationships between sRPE and several other measures of training intensity and load. Stepwise multiple regressions were used to determine a predictive equation to estimate sRPE during dance training.Results:Average weekly training load was 4283 ± 2442 arbitrary units (AU), monotony 2.13 ± 0.92 AU, strain 10677 ± 9438 AU, and average weekly vector magnitude load 1809,707 ± 1015,402 AU. There were large to very large within-individual correlations between training-load sRPE and various other internal and external measures of intensity and load. The stepwise multiple-regression analysis also revealed that 49.7% of the adjusted variance in training-load sRPE was explained by peak heart rate, metabolic equivalents, soreness, motivation, and sleep quality (y = –4.637 + 13.817%HRpeak + 0.316 METS + 0.100 soreness + 0.116 motivation – 0.204 sleep quality).Conclusion:The current findings demonstrate the validity of the sRPE method for quantifying training load in dance, that dancers undertake very high training loads, and a combination of training and nontraining factors contribute to perceived exertion in dance training.
A Comparison of Speed Profiles During Training and Competition in Elite Wheelchair Rugby Players
Authors: Rhodes James M. , Mason Barry S. , Paulson Thomas A.W. , Goosey-Tolfrey Victoria L. 
Published: November 2016

Purpose:To investigate the speed profiles of individual training modes in comparison with wheelchair rugby (WCR) competition across player classifications.Methods:Speed profiles of 15 international WCR players were determined using a radio-frequency-based indoor tracking system. Mean and peak speed (m/s), work:rest ratios, and the relative time spent in (%) and number of high-speed activities performed were measured across training sessions (n = 464) and international competition (n = 34). Training was classified into 1 of 4 modes: conditioning (n = 71), skill-based (n = 133), game-related (n = 151), and game-simulation drills (n = 109). Game-simulation drills were further categorized by the structured duration, which were 3-min game clock (n = 44), 8-min game clock (n = 39), and 10-min running clock (n = 26). Players were grouped by their International Wheelchair Rugby Federation classification as either low-point (≤1.5; n = 8) or high-point players (≥2.0; n = 7).Results:Conditioning drills were shown to exceed the demands of competition, irrespective of classification (P ≤ .005; effect size [ES] = 0.6–2.0). Skill-based and game-related drills underrepresented the speed profiles of competition (P ≤ .005; ES = 0.5–1.1). Mean speed and work:rest ratios were significantly lower during 3- and 8-min game-simulation drills in relation to competition (P ≤ .039; ES = 0.5–0.7). However, no significant differences were identified between the 10-min running clock and competition.Conclusions:Although game-simulation drills provided the closest representation of competition, the structured duration appeared important since the 10-min running clock increased training specificity. Coaches can therefore modify the desired training response by making subtle changes to the format of game-simulation drills.
Predicting Critical Power in Elite Cyclists: Questioning the Validity of the 3-Minute All-Out Test
Authors: Bartram Jason C. , Thewlis Dominic , Martin David T. , Norton Kevin I. 
Published: November 2016

Purpose:New applications of the critical-power concept, such as the modeling of intermittent-work capabilities, are exciting prospects for elite cycling. However, accurate calculation of the required parameters is traditionally time invasive and somewhat impractical. An alternative single-test protocol (3-min all-out) has recently been proposed, but validation in an elite population is lacking. The traditional approach for parameter establishment, but with fewer tests, could also prove an acceptable compromise.Methods:Six senior Australian endurance track-cycling representatives completed 6 efforts to exhaustion on 2 separate days over a 3-wk period. These included 1-, 4-, 6-, 8-, and 10-min self-paced efforts, plus the 3-min all-out protocol. Traditional work-vs-time calculations of CP and anaerobic energy contribution (W′) using the 5 self-paced efforts were compared with calculations from the 3-min all-out protocol. The impact of using just 2 or 3 self-paced efforts for traditional CP and W′ estimation was also explored using thresholds of agreement (8 W, 2.0 kJ, respectively).Results:CP estimated from the 3-min all-out approach was significantly higher than from the traditional approach (402 ± 33, 351 ± 27 W, P < .001), while W′ was lower (15.5 ± 3.0, 24.3 ± 4.0 kJ, P = .02). Five different combinations of 2 or 3 self-paced efforts led to CP estimates within the threshold of agreement, with only 1 combination deemed accurate for W′.Conclusions:In elite cyclists the 3-min all-out approach is not suitable to estimate CP when compared with the traditional method. However, reducing the number of tests used in the traditional method lessens testing burden while maintaining appropriate parameter accuracy.
Prediction of Functional Overreaching From Subjective Fatigue and Readiness to Train After Only 3 Days of Cycling
Authors: ten Haaf Twan , van Staveren Selma , Oudenhoven Erik , Piacentini Maria F. , Meeusen Romain , Roelands Bart , Koenderman Leo , Daanen Hein A.M. , Foster Carl , de Koning Jos J. 
Published: November 2016

Purpose:To investigate whether monitoring of easily measurable stressors and symptoms can be used to distinguish early between acute fatigue (AF) and functional overreaching (FOR).Methods:The study included 30 subjects (11 female, 19 male; age 40.8 ± 10.8 y, VO2max 51.8 ± 6.3 mL · kg–1 · min–1) who participated in an 8-d cycling event over 1300 km with 18,500 climbing meters. Performance was measured before and after the event using a maximal incremental test. Subjects with decreased performance after the event were classified as FOR, others as AF. Mental and physical well-being, internal training load, resting heart rate, temperature, and mood were measured daily during the event. Differences between AF and FOR were analyzed using mixed-model ANOVAs. Logistic regression was used to determine the best predictors of FOR after 3 and 6 d of cycling.Results:Fifteen subjects were classified as FOR and 14 as AF (1 excluded). Although total group changes were observed during the event, no differences between AF and FOR were found for individual monitoring parameters. The combination of questionnaire-based changes in fatigue and readiness to train after 3 d cycling correctly predicted 78% of the subjects as AF or FOR (sensitivity = 79%, specificity = 77%).Conclusions:Monitoring changes in fatigue and readiness to train, using simple visual analog scales, can be used to identify subjects likely to become FOR after only 3 d of cycling. Hence, we encourage athlete support staff to monitor not only fatigue but also the subjective integrated mental and physical readiness to perform.
Interscholastic Competitive Balance: An Examination of State Athletic Association Administrators
Authors: Johnson James E. , Giannoulakis Chrysostomos , Scott Beau F. 
Published: November 2016

While competitive balance literature is robust when addressing professional sport from an economic perspective, little empirical work has focused on understanding what shapes interscholastic competitive balance policies. Using the theory of distributive justice as a framework, the purpose of this multiple case study was to examine the perceptions of top administrators regarding sociocultural influences on interscholastic competitive balance. Qualitative interview data collected from six state commissioners/executive directors revealed four predominant findings: (a) policy is driven by a philosophical approach that is aligned with the theory of distributive justice; (b) an overemphasis on winning strongly influences policy; (c) political influence through legal threats and state educational policy shapes committee decisions; and (d) the prevailing challenges of policy creation include school size, geography, public/nonpublic status, tradition, sport-specific characteristics, and lack of knowledge. Implications of these findings are discussed.
Patient Outcomes Utilizing the Mulligan Concept of Mobilization With Movement to Treat Intercollegiate Patients Diagnosed With Lateral Ankle Sprain: An a Priori Case Series
Authors: May James M. , Nasypany Alan , Paolino Julie , Baker Russell , Seegmiller Jeffrey 
Published: November 2016

Context:While the incidence and reinjury rates of lateral ankle sprain (LAS) continue to persist at high rates across many sporting activities, further exploration of assessment and treatment beyond the traditional ligamentous and strength/proprioceptive model is warranted. Further, assessing and treating both arthrokinematic and osteokinematic changes associated with LAS can provide insight into a more diverse approach to treating ankle pathology.Objective:To examine the clinical use of the Mulligan Concept mobilization with movement (MWM) while treating patients diagnosed with an acute grade I or II LAS through authentic patient care.Design:An a priori case series.Setting:Intercollegiate athletic training clinic.Patients:Intercollegiate patients diagnosed with an acute grade I or II LAS.Intervention:The Mulligan Concept distal fibular anterior to posterior MWM.Main Outcome Measures:Pain-Intensity Numeric Rating Scale (NRS) with Non-Weight Bearing (NRS-NWB) and Weight Bearing (NRS-WB), Disablement of the Physically Active Scale (DPAscale), Foot and Ankle Ability Measure (FAAM) with Activity of Daily living (FAMM-ADL) and Sport (FAAM-Sport), Client Specific Impairment Measure (CSIM), Y-Balance Composite (YBC), and Weight Bearing Measure for Dorsiflexion (WBDF).Results:Patients who are diagnosed with an acute grade I or II LAS and are treated with the Mulligan Concept report immediate and long-lasting minimal clinically important differences in patient outcome measures.Conclusion:Clinicians who examine and use the Mulligan Concept MWM to treat acute LAS can expect immediate positive results that are progressively retained over time specific to patient-centered outcome measures as well as functional clinicianbased measures. Based on the immediate and positive results, clinicians should examine associated osteokinematic and arthrokinematic changes beyond that of the traditional ligamentous model.
Neural correlates of ticklishness in the rat somatosensory cortex
Authors: Ishiyama S. , Brecht M. 
Published: November 2016

Resolving a ticklish problem
What is the neural correlate of ticklishness? When Ishiyama and Brecht tickled rats, the animals produced noises and other joyful responses. During the tickling, the authors observed nerve cell activity in deep layers of the somatosensory cortex corresponding to the animals' trunks. Furthermore, microstimulation of this brain region evoked the same behavior. Just as in humans, mood could modulate this neuronal activity. Anxiety-inducing situations suppressed the cells' firing, and the animal could no longer be tickled.

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Lipid Mediators in Inflammation
Authors: Bennett Melanie , Gilroy Derek W. 
Published: November 2016

ABSTRACTLipids are potent signaling molecules that regulate a multitude of cellular responses, including cell growth and death and inflammation/infection, via receptor-mediated pathways. Derived from polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), each lipid displays unique properties, thus making their role in inflammation distinct from that of other lipids derived from the same PUFA. This diversity arises from their synthesis, which occurs via discrete enzymatic pathways and because they elicit responses via different receptors. This review will collate the bioactive lipid research to date and summarize the major pathways involved in their biosynthesis and role in inflammation. Specifically, lipids derived from AA (prostanoids, leukotrienes, 5-oxo-6,8,11,14-eicosatetraenoic acid, lipoxins, and epoxyeicosatrienoic acids), EPA (E-series resolvins), and DHA (D-series resolvins, protectins, and maresins) will be discussed herein.
Distributed Halide
Authors: Denniston Tyler , Kamil Shoaib , Amarasinghe Saman 
Published: November 2016

Many image processing tasks are naturally expressed as a pipeline of small computational kernels known as stencils. Halide is a popular domain-specific language and compiler designed to implement image processing algorithms. Halide uses simple language constructs to express what to compute and a separate scheduling co-language for expressing when and where to perform the computation. This approach has demonstrated performance comparable to or better than hand-optimized code. Until now, however, Halide has been restricted to parallel shared memory execution, limiting its performance for memory-bandwidth-bound pipelines or large-scale image processing tasks.
We present an extension to Halide to support distributed-memory parallel execution of complex stencil pipelines. These extensions compose with the existing scheduling constructs in Halide, allowing expression of complex computation and communication strategies. Existing Halide applications can be distributed with minimal changes, allowing programmers to explore the tradeoff between recomputation and communication with little effort. Approximately 10 new of lines code are needed even for a 200 line, 99 stage application. On nine image processing benchmarks, our extensions give up to a 1.4× speedup on a single node over regular multithreaded execution with the same number of cores, by mitigating the effects of non-uniform memory access. The distributed benchmarks achieve up to 18× speedup on a 16 node testing machine and up to 57× speedup on 64 nodes of the NERSC Cori supercomputer.
Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematical models
Authors: Kurata Yasutaka , Tsumoto Kunichika , Hayashi Kenshi , Hisatome Ichiro , Tanida Mamoru , Kuda Yuhichi , Shibamoto Toshishige 
Published: November 2016

Early afterdepolarization (EAD) is known as a cause of ventricular arrhythmias in long QT syndromes. We theoretically investigated how the rapid ( IKr) and slow ( IKs) components of delayed-rectifier K+ channel currents, L-type Ca2+ channel current ( ICaL), Na+/Ca2+ exchanger current ( INCX), Na+-K+ pump current ( INaK), intracellular Ca2+ (Cai) handling via sarcoplasmic reticulum (SR), and intracellular Na+ concentration (Nai) contribute to initiation, termination, and modulation of phase-2 EADs, using two human ventricular myocyte models. Bifurcation structures of dynamical behaviors in model cells were explored by calculating equilibrium points, limit cycles (LCs), and bifurcation points as functions of parameters. EADs were reproduced by numerical simulations. The results are summarized as follows: 1) decreasing IKs and/or IKr or increasing ICaL led to EAD generation, to which mid-myocardial cell models were especially susceptible; the parameter regions of EADs overlapped the regions of stable LCs. 2) Two types of EADs (termination mechanisms), IKs activation–dependent and ICaL inactivation–dependent EADs, were detected; IKs was not necessarily required for EAD formation. 3) Inhibiting INCX suppressed EADs via facilitating Ca2+-dependent ICaL inactivation. 4) Cai dynamics (SR Ca2+ handling) and Nai strongly affected bifurcations and EAD generation in model cells via modulating ICaL, INCX, and INaK. Parameter regions of EADs, often overlapping those of stable LCs, shifted depending on Cai and Nai in stationary and dynamic states. 5) Bradycardia-related induction of EADs was mainly due to decreases in Nai at lower pacing rates. This study demonstrates that bifurcation analysis allows us to understand the dynamical mechanisms of EAD formation more profoundly. NEW & NOTEWORTHY We investigated mechanisms of phase-2 early afterdepolarization (EAD) by bifurcation analyses of human ventricular myocyte (HVM) models. EAD formation in paced HVMs basically depended on bifurcation phenomena in non-paced HVMs, but was strongly affected by intracellular ion concentrations in stationary and dynamic states. EAD generation did not necessarily require IKs.
Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/− mice
Authors: Ballmann Christopher , Denney Thomas S. , Beyers Ronald J. , Quindry Tiffany , Romero Matthew , Amin Rajesh , Selsby Joshua T. , Quindry John C. 
Published: November 2016

Duchenne Muscular Dystrophy (DMD) is associated with progressive cardiac pathology; however, the SIRT1/PGC1-α activator quercetin may cardioprotect dystrophic hearts. We tested the extent to which long-term 0.2% dietary quercetin enrichment attenuates dystrophic cardiopathology in Mdx/Utrn+/− mice. At 2 mo, Mdx/Utrn+/− mice were fed quercetin-enriched (Mdx/Utrn+/−-Q) or control diet (Mdx/Utrn+/−) for 8 mo. Control C57BL/10 (C57) animals were fed a control diet for 10 mo. Cardiac function was quantified by MRI at 2 and 10 mo. Spontaneous physical activity was quantified during the last week of treatment. At 10 mo hearts were excised for histological and biochemical analysis. Quercetin feeding improved various physiological indexes of cardiac function in diseased animals. Mdx/Utrn+/−-Q also engaged in more high-intensity physical activity than controls. Histological analyses of heart tissues revealed higher expression and colocalization of utrophin and α-sarcoglycan. Lower abundance of fibronectin, cardiac damage (Hematoxylin Eosin-Y), and MMP9 were observed in quercetin-fed vs. control Mdx/Utrn+/− mice. Quercetin evoked higher protein abundance of PGC-1α, cytochrome c, ETC complexes I–V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/−. Quercetin decreased abundance of inflammatory markers including NFκB, TGF-β1, and F4/80 compared with Mdx/Utrn+/−; however, P-NFκB, P-IKBα, IKBα, CD64, and COX2 were similar between groups. Dietary quercetin enrichment improves cardiac function in aged Mdx/Utrn+/− mice and increases mitochondrial protein content and dystrophin glycoprotein complex formation. Histological analyses indicate a marked attenuation in pathological cardiac remodeling and indicate that long-term quercetin consumption benefits the dystrophic heart. NEW & NOTEWORTHY The current investigation provides first-time evidence that quercetin provides physiological cardioprotection against dystrophic pathology and is associated with improved spontaneous physical activity. Secondary findings suggest that quercetin-dependent outcomes are in part due to PGC-1α pathway activation.