bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract C077: A statewide investigation of lung cancer survival and exposure to radon
Authors: Al Ksir Kawther 
Published: September 2024

Abstract
Background: Cancer is the second leading cause of death in the United States (U.S.), with one in four deaths attributed to it according to the Centers for Disease Control and Prevention (CDC). Lung cancer is the third most common cancer overall and the leading cause of cancer-related deaths across all races, ethnicities, and genders. The United States Environmental Protection Agency (USEPA) identifies radon as the second leading cause of lung cancer and the primary cause among non-smokers. Radon, a naturally occurring radioactive gas from the decay of radium, is colorless, odorless, tasteless, chemically inert, and poses a significant health risk. Health disparities in lung cancer survival are pronounced among underserved communities, including racial and ethnic minorities and individuals from lower socioeconomic backgrounds. These disparities are influenced by factors such as reduced access to healthcare, differences in environmental exposures, and variations in the prevalence of risk factors like smoking. Tennessee ranks 45th among the 50 states with an average indoor radon level of 3.9 pCi/L. This study aims to evaluate lung cancer survival, focusing on factors such as age, sex, residential radon exposure, diagnostic stage, and smoking status, with a particular emphasis on underserved populations. Methods: Data on lung cancer cases by county will be sourced from the Tennessee Cancer Registry (TCR), a comprehensive data system that collects detailed information on cancer diagnoses and treatments among Tennessee residents. Indoor radon levels will be categorized as low (≤2 pCi/L), moderate (2-4 pCi/L), and high (&gt;4 pCi/L). Smoking prevalence data by county will be obtained from the County Health Rankings and Roadmaps. This study will analyze lung cancer survival rates in relation to these variables, paying special attention to disparities among underserved communities. Conclusion: This study will provide insights into how residential radon exposure and smoking influence lung cancer survival disparities in Tennessee. By examining these factors alongside demographic variables and diagnostic stages, particularly in underserved communities, the findings may inform targeted public health interventions and policies aimed at reducing lung cancer disparities in the state.
Citation Format: Kawther Al Ksir. A statewide investigation of lung cancer survival and exposure to radon [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C077.
Abstract C079: Investigating the interplay among allostatic load, social determinants of health, and treatment outcomes in chronic myeloid leukemia patients
Authors: Miranda-Galvis Marisol , Sharara Muhannad , Tjioe Kellen C. , Maloney McKenzie Maloney , Kota Vamsi , Jillella Anand , Bryan Locke , Keruakous Amany R. , Cortes Jorge E. 
Published: September 2024

Abstract
This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR011) of the Conference Program/Proceedings.
Citation Format: Marisol Miranda-Galvis, Muhannad Sharara, Kellen C. Tjioe, McKenzie Maloney Maloney, Vamsi Kota, Anand Jillella, Locke Bryan, Amany R. Keruakous, Jorge E. Cortes. Investigating the interplay among allostatic load, social determinants of health, and treatment outcomes in chronic myeloid leukemia patients [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C079.
Abstract C086: Somatic mutation variations in minority populations at the University of New Mexico Comprehensive Cancer Center
Authors: Doan Isabella , Coy Jonathan , Tawfik Bernard 
Published: September 2024

Abstract
The global burden of cancer underscores the urgency to understand its genetic underpinnings. Genetic testing has revolutionized clinical practice, identifying driver mutations crucial for tumorigenesis, including TP53, PIK3CA, KRAS, PTEN, and ARID1A. However, minority populations are underrepresented in major genomic projects, hindering tailored therapies. Variations in genetic polymorphisms among ethnicities, exemplified by distinct patterns in mutations like BRCA and EGFR, underscore the imperative for diversity in genomic research. We conducted a retrospective study at the University of New Mexico Comprehensive Cancer Center, analyzing 5,045 patients' genetic testing data. Significant differences in somatic gene mutation frequencies and survival outcomes were observed across racial and ethnic groups, highlighting the importance of personalized approaches in cancer care. Specific gene mutations, such as IDH1, JAK2, KITX11, and TP53, were associated with distinct survival outcomes. Integrating genetic testing into routine practice could enhance patient stratification and treatment efficacy. Future research should explore underlying mechanisms and include larger, diverse populations to advance personalized medicine in oncology.
Citation Format: Isabella Doan, Jonathan Coy, Bernard Tawfik. Somatic mutation variations in minority populations at the University of New Mexico Comprehensive Cancer Center [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C086.
Abstract C102: Polyethnic-1000: Advancing cancer genomics by studying ethnically diverse, underserved patient populations in New York
Authors: Robine Nicolas , Winterkorn Lara , Chu Tim , Goldstein Zoe , Hooper Will , Oku Ali , Geiger Heather M. , Davis Melissa B. , Balogun Onyinye 
Published: September 2024

Abstract
Prompted by the considerable biases toward European ancestry cases in large cancer genomics repositories, the New York Genome Center initiated an effort to diversify the public datasets that are forming the foundations of current cancer research, in order to optimize the unbiased applications of modern genomically-driven discoveries to a larger population. Our effort was focused on 8 cancer types (breast, prostate, bladder, lung, pancreatic, colon and endometrial cancer, as well as multiple myeloma) and generated Illumina tumor-normal whole-genome sequencing and tumor transcriptome sequencing. The majority of the samples were retrospectively obtained in clinics and hospitals of the New York region and the analyses are conducted with collaborators in these institutions. Our dataset is currently composed of 851 tumor-normal WGS and 471 RNASeq, and is progressively being distributed to the scientific community in partnership with ICGC-ARGO. Overall, 75% of the cohort is predominantly of non-European ancestry, as estimated by genetic ancestry analysis using the 1000Genomes continental references.We analyzed the samples with NYGC’s somatic variant calling pipeline and will present results from the 8 cancer types related to germline and somatic variants (single-nucleotide variants, indels, copy-number alterations, complex structural variants) as well as mutational signatures, neoantigen prediction, fusion genes and expression profiles, in relation to genetic ancestry estimation and clinical features of the patients. We anticipate that the dataset will significantly diversify the genetic ancestry of tumor profiles in public databases, and serve to form hypotheses regarding the contribution of ancestry on cancer disparities. The experience of the Polyethnic-1000 project informs our contribution to the Cancer Grand Challenge SAMBAI, which focuses on breast, prostate and pancreatic cancers in the African Diaspora. SAMBAI will further investigate the causes of cancer disparity by combining genomic data with social determinants of health and exposomics information, deeper immune profiling and new genomics technologies such as long reads sequencing and the use of a pangenome reference.
Citation Format: Nicolas Robine, Lara Winterkorn, Tim Chu, Zoe Goldstein, Will Hooper, Ali Oku, Heather M. Geiger, Melissa B. Davis, Onyinye Balogun. Polyethnic-1000: Advancing cancer genomics by studying ethnically diverse, underserved patient populations in New York [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C102.
Abstract C115: Chromatin acetylation at H3K9ac, inflammatory signaling, and evidence for immune cell senescence in Los Angeles women with insulin-resistance
Authors: Vidal Christina M. , Alva-Ornelas Jackelyn A. , Senapati Parijat , Tomsic Jerneja , Seewaldt Victoria L. 
Published: September 2024

Abstract
Insulin-resistance (IR) is a known risk factor for diabetes and has been shown to lead to epigenetic dysregulation, such as inappropriate chromatin opening, and inflammation. In Los Angeles one-third of Young Women of Color are insulin-resistant, making them at risk for Type- 2 Diabetes, and triple negative breast cancer. In our current study we tested 28 women living in Los Angeles for insulin-resistance, chromatin acetylation, and tissue inflammation. Our ChIP- seq studies provide evidence that in IR women, there is increased acetylation of H3K9ac at the promoters of IL6, TNFα, and NFkB/IRF1 (regulator in INF-beta signaling). Cytokine arrays corroborate these findings and show increased production of INFβ, IL6, and TNFα. Interestingly IL6 and TNFα are known cytokines excreted by a senescence-associated secretory phenotype (SASP) factors. Additionally, NFkB is a mediator of SASP induction, which prompted us to investigate senescence in these women. We found that in IR women there is an increase in senescent naïve CD4 T cells and CD4 T helper 1 (Th1) and Th17 cells. Given the important role that inflammation and senescence has on cancer initiation and progression, our findings provide a potential link between insulin-resistance, inflammation/senescence, and cancer.
Citation Format: Christina M. Vidal, Jackelyn A. Alva-Ornelas, Parijat Senapati, Jerneja Tomsic, Victoria L. Seewaldt. Chromatin acetylation at H3K9ac, inflammatory signaling, and evidence for immune cell senescence in Los Angeles women with insulin-resistance [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C115.
Abstract C116: Prevalence and Implication of Aflatoxin B1 expression in colon cancers diagnosed in Southern Nigeria
Authors: Delu-mozie Chiagoziem Moral 
Published: September 2024

Abstract
Introduction: Mounting evidence shows that there is a high prevalence of late-stage, aggressive, and metastatic adenocarcinoma of the colon (AdCC) in Africa, with high mortality and low survival rate among patients. Literature finger food contaminants such as mycotoxin, especially Aflatoxin, as an attributable factor to the high incidence of abdominal cancers. However, there is a paucity of studies to confirm the hypothesis. Hence, this study determined the prevalence of Aflatoxin B1 in AdCC in Southern Nigeria.
Citation Format: Chiagoziem Moral Delu-mozie. Prevalence and Implication of Aflatoxin B1 expression in colon cancers diagnosed in Southern Nigeria [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C116.
Abstract C136: Impact of the Affordable Care Act on receipt of guideline-concordant care for colon cancer
Authors: Kudaravalli Sriya , Ober Nicole , Sun Zhaojun , Bhattacharya Manisha , Jacobs Bruce , Sabik Lindsay 
Published: September 2024

Abstract
This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR007) of the Conference Program/Proceedings.
Citation Format: Sriya Kudaravalli, Nicole Ober, Zhaojun Sun, Manisha Bhattacharya, Bruce Jacobs, Lindsay Sabik. Impact of the Affordable Care Act on receipt of guideline-concordant care for colon cancer [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C136.
Abstract C152: Improving Access to Genetic Services for Women with Breast Cancer from Underserved Communities in California: Design and Implementation of a Community- Engaged Program
Authors: Gallo Iñigo Verduzco , Villa Nanci Chavarria , Rolon Angelica , Carvajal Guadalupe , Estrada-Florez Ana P. , Carvajal-Carmona Luis G 
Published: September 2024

Abstract
This study aims to understand the barriers to genetic services uptake at the patient, provider, and healthcare system levels, and to develop a multi-level intervention to increase access and suitability to genetic services for women from minority and medically underserved populations in California who have been recently diagnosed with breast cancer. Germline-informed cancer screening has been found to improve breast cancer survival and help identify close relatives who may have an inherited mutation that increases their susceptibility to cancer. However, only 26% of women diagnosed with breast cancer reported having germline genetic testing; marginalized populations are less likely to receive these services (Kurian et al., 2023). Using Levesque’s Conceptual Framework (Lévesque et al., 2013) and Implementation Mapping (Fernández et al., 2019), we are iteratively developing a multi-level program to explore the role that Community Health Workers (CHWs)/Promotoras can play in reducing access disparities to genetic services. Eleven CHWs/Promotoras have completed 80 hours of CHW training, 7 hours of mental health, insurance and group facilitation training, and 14 hours of cancer health training. CHWs/Promotoras have established local community breast cancer groups in their local communities across California’s Central Valley and are participating in and organizing breast cancer health fairs in their communities in partnership with Community Based Organizations (CBOs). Identifying and addressing the barriers to genetic services is critical to reducing access disparities to genetic services for underserved populations. CHWs/Promotoras are a promising resource to help reduce existing disparities in genetic services for women diagnosed with breast cancer.
Citation Format: Iñigo Verduzco Gallo, Nanci Chavarria Villa, Angelica Rolon, Guadalupe Carvajal, Ana P. Estrada-Florez, Luis G Carvajal-Carmona. Improving Access to Genetic Services for Women with Breast Cancer from Underserved Communities in California: Design and Implementation of a Community- Engaged Program [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C152.
Abstract C173: Influence of Socio-Demographic and Lifestyle Factors on Lung Cancer Incidence Among African American and European American
Authors: Eswaran Murugesh , Briana A Brock Briana A , Mir Hina Abdulrehman , Flenaugh Eric L. , Gabriela Oprea M. , Rivers Brian , Singh Rajesh , Singh Shailesh 
Published: September 2024

Abstract
The persistent gap in cancer incidence and outcomes between African American (AA) and European American (EA) populations remains a significant public health challenge. Understanding these discrepancies is pivotal for crafting targeted interventions to mitigate health disparities. To comprehensively assess these inequalities, this study delves into the association between smoking and lung cancer incidence within a diverse cohort of 5270 participants, comprising both AA (868 participants) and EA (3137 participants) individuals. Among the 2901 lung cancer patients identified in our analysis, diagnoses ranged from Malignant Tumors of the Lung to various subtypes of Non-Small Cell and Small Cell Lung Cancer. Surprisingly, only a significant subset of these patients were smokers, with statistical analysis indicating a p&lt;0.001, pointing to other influential demographic factors. Employing the Chi-Square Test of Independence, Logistic Regression, and Multivariate Analysis, we evaluated the impact of smoking alongside additional variables on lung cancer incidence. Factors such as Age, Gender, Socioeconomic Status, Occupational Exposures, Geographic Location, Family History of Cancer, Comorbidities, and Lifestyle Factors were considered in the multivariate analyses to ascertain their contribution to lung cancer risks. Our findings from Relative Risk (RR) and Attributable Risk (AR) assessments suggest that while smoking constitutes a notable risk factor, a substantial proportion of lung cancer cases in this cohort were not linked to smoking. Stratified and Sensitivity Analyses further unveiled nuanced risk profiles within subgroups, elucidating the intricate interplay between lifestyle factors and genetic predispositions. Our study highlights that a significant portion of lung cancer cases, particularly among EA and AA populations, occur in non-smokers, with smoking often associated with other comorbidities rather than solely lung- specific diseases. This underscores the multifaceted nature of lung cancer risk factors across different racial groups, advocating for public health strategies that address a broader spectrum of influences beyond smoking to combat cancer disparities within these communities effectively.
Citation Format: Murugesh Eswaran, Briana A Briana A Brock, Hina Abdulrehman Mir, Eric L. Flenaugh, Oprea M. Gabriela, Brian Rivers, Rajesh Singh, Shailesh Singh. Influence of Socio-Demographic and Lifestyle Factors on Lung Cancer Incidence Among African American and European American [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C173.
Abstract C180: Not all PIRADS 3s are equal; fusion biopsy outcomes by PIRADS score and ethnicity in a diverse population
Authors: Hanelin David G. , Baca Andrewe , Dave Priya , Patel Rutul , Agalliu Ilir , Sankin Alexander , Aboumohamed Ahmed , Watts Kara 
Published: September 2024

Abstract
Introduction and Objective: Magnetic resonance imaging (MRI) is increasingly utilized in the diagnosis of prostate cancer (PCa). Although PIRADS 3 lesions have been associated with a lower likelihood of detecting clinically significant prostate cancer (csPCa) at the time of targeted fusion biopsy (FB), existing data on multiethnic populations are sparse. We assessed the pathologic concordance of PIRADS 3 vs 4 or 5 lesions in detection of PCa and csPCa in comparison to PSA density in a diverse population. Methods: A retrospective study of all patients who underwent image-guided FB for PIRADS 3-5 lesions from 2016-2022 was conducted. Demographic, clinical, and pathologic data were extracted from electronic medical records. Mixed-effects logistic regression models were used to examine the association of race/ethnicity and PSA density with risks of overall PCa and csPCa. A stratified analysis by PIRADS score (3 vs 4 or 5) was also carried out to explore the associations between detection rates of PCa and race/ethnicity. Results: A total of 565 men with 997 lesions were analyzed, with average age 63.2 years (SD: 7.5) at the time of biopsy. Of the men, 279 (49.4%) were Non-Hispanic Black (NHB), 112 (19.8%) were Non-Hispanic White, and 174 (30.8%) were Hispanic. 520 (52.16%), 310 (31.09%), and 167 (16.75%) individual MRI lesions were PIRADS 3, 4, and 5, respectively with distributions of PIRADS scores being similar across all race/ethnicities. The overall rates of PCa detection were 44.8% in NHB, 37.6% in Hispanics, and 33.0% in NHW. Compared to NHW, NHB has 2.52 higher odds of detecting overall PCa (95% CI 1.10-5.78; p = 0.03), whereas Hispanic men had an OR = 1.18 (p = 0.72). Interestingly, the increase in PCa detection among NHB was only observed for PIRADs 3 lesions (OR = 4.84 95% CI 1.11-21.2, p = 0.04). NHB men also had 2.1-fold higher odds of detecting csPCa (95% CI 0.92-4.77; p = 0.08) in comparison to NHW with a similar trend mimicking association with PRIADS scores, although results were not statistically significant. Conclusions: We report that NHB men have higher odds of detection rates of overall PCa in FB in comparison to NHW and Hispanic men, albeit only at PIRADS 3 scores. These findings may serve to improve risk stratification and assist with shared decision making when discussing triggers for biopsy. Source of funding: None
Citation Format: David G. Hanelin, Andrewe Baca, Priya Dave, Rutul Patel, Ilir Agalliu, Alexander Sankin, Ahmed Aboumohamed, Kara Watts. Not all PIRADS 3s are equal; fusion biopsy outcomes by PIRADS score and ethnicity in a diverse population [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C180.
Industrial Restructuring as a Driving Force in China’s Africa Policy: a Case Study of China’s Ethiopia Policy
Authors: Ge Xiaochang 
Published: September 2024

Abstract
Existing research suggests that natural resources, domestic markets, and decisive political influence attract China to build relationships with African countries. However, why China sought to deepen its relationship with Ethiopia since the mid-1990s despite its lack of these endowments? This article aims to address this empirical puzzle by combining theoretical perspectives from development economics and fragmented authoritarianism to analyse the driving factors behind China’s Ethiopia policy and its formulation and implementation process. Examining China’s diplomacy towards Ethiopia from 1995–2019, it finds that Ethiopia’s stable society and abundant labour force made it a key destination for China’s industrial transfer. And China’s need for industrial restructuring has driven its Ethiopia policy, with private enterprises playing a crucial role by proposing projects. These findings enrich the understanding of the motivations and processes behind China’s influence in Africa from an industrial restructuring perspective, offering insights into China’s diplomacy and its impact on Africa.