bluuebunny/crossref_metadata_2025_split huggingface dataset:
Replacing a phosphodiesterase‐5 inhibitor with riociguat in patients with connective tissue disease‐associated pulmonary arterial hypertension: a case series
Authors: Raina Amresh , Benza Raymond L. , Farber Harrison W. 
Published: July 2017

Patients with pulmonary arterial hypertension associated with connective tissue disease (PAH‐PAH‐CTD) such as systemic sclerosis (SSc) have a poorer response to treatment and increased mortality compared with patients with idiopathic PAH. Current treatment options for PAH‐CTD include prostanoids, phosphodiesterase type‐5 inhibitors (PDE‐5i), endothelin receptor antagonists, and the soluble guanylate cyclase stimulator riociguat. In this case series, we describe three patients with PAH‐CTD related to limited scleroderma who were switched from a PDE‐5i to riociguat due to insufficient clinical response. The switch to riociguat was associated with an improvement in respiratory and hemodynamic parameters and a favorable tolerability profile. These cases demonstrate that switching to riociguat is a therapeutic option in patients with PAH‐CTD who have not achieved a satisfactory clinical response to a PDE‐5i.
Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis
Authors: Glogowska Edyta , Schneider Eve R. , Maksimova Yelena , Schulz Vincent P. , Lezon-Geyda Kimberly , Wu John , Radhakrishnan Kottayam , Keel Siobán B. , Mahoney Donald , Freidmann Alison M. , Altura Rachel A. , Gracheva Elena O. , Bagriantsev Sviatoslav N. , Kalfa Theodosia A. , Gallagher Patrick G. 
Published: July 2017

Key Points
There is heterogeneity in the clinical, laboratory, and genetic bases of HX. Alterations in PIEZO1 channel kinetics, response to osmotic stress, and membrane trafficking may contribute to channel dysfunction in HX.
Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyan clinical isolate defines a core parasite secretome
Authors: Abdi Abdirahman , Yu Lu , Goulding David , Rono Martin K. , Bejon Philip , Choudhary Jyoti , Rayner Julian 
Published: July 2017

Background: Many pathogens secrete effector molecules to subvert host immune responses, to acquire nutrients, and/or to prepare host cells for invasion. One of the ways that effector molecules are secreted is through extracellular vesicles (EVs) such as exosomes. Recently, the malaria parasite P. falciparum has been shown to produce EVs that can mediate transfer of genetic material between parasites and induce sexual commitment. Characterizing the content of these vesicles may improve our understanding of P. falciparum pathogenesis and virulence. Methods: Previous studies of P. falciparum EVs have been limited to long-term adapted laboratory isolates. In this study, we isolated EVs from a Kenyan P. falciparum clinical isolate adapted to in vitro culture for a short period and characterized their protein content by mass spectrometry (data are available via ProteomeXchange, with identifier PXD006925). Results: We show that P. falciparum extracellular vesicles (PfEVs) are enriched in proteins found within the exomembrane compartments of infected erythrocytes such as Maurer’s clefts (MCs), as well as the secretory endomembrane compartments in the apical end of the merozoites, suggesting that these proteins play a role in parasite-host interactions. Comparison of this novel clinically relevant dataset with previously published datasets helps to define a core secretome present in Plasmodium EVs. Conclusions: P. falciparum extracellular vesicles contain virulence-associated parasite proteins. Therefore, analysis of PfEVs contents from a range of clinical isolates, and their functional validation may improve our understanding of the virulence mechanisms of the parasite, and potentially identify targets for interventions or diagnostics.
Reliability of patellar height indices in children with cerebral palsy and spina bifida
Authors: Rethlefsen S. A. , Barrett K. K. , Wren T. A. L. , Blumstein G. , Gargiulo D. , Ryan D. D. , Kay R. M. 
Published: July 2017

Background The Koshino (KI) and Caton-Deschamps (CDI) indices are used to measure patellar height in children, with the CDI showing excellent reliability in typically developing (TD) children. Reliability of such measures in children with cerebral palsy (CP) and spina bifida (SB) is unknown. Methods Lateral knee radiographs were reviewed retrospectively for children with TD (n = 49), CP (n = 48) and SB (n = 42). Five raters took measurements from radiographs twice, at least two weeks apart. Measurements included the CDI, Insall-Salvati Index (ISI) and KI. Systematic variability (bias) and random variability were examined using repeated measures ANOVA, 95% limits of agreement (LOA) and coefficients of variation (CV). Results Mean values of all three indices differed among raters (p < 0.0001). A significant difference was seen between the first and second measurements for CDI and KI indicating a learning effect. LOA ranges were large for the CDI (intra-rater: 0.37-0.95, inter-rater: 0.60-1.04) and ISI (intra-rater: 0.25-0.49, inter-rater: 0.51-0.57) for all patient groups. The KI showed a clinically acceptable range for TD participants (intra-rater: 0.14-0.16, inter-rater: 0.11-0.14) with larger ranges for CP (intra-rater: 0.26-0.33, inter-rater 0.0.2-0.35) and SB patients (intra-rater: 0.23-0.27, inter-rater: 0.19-0.25). CVs were lowest (best) for KI (3.8% to 7.4%) and highest (worst) for CDI (14.7% to 23.1%) for all three groups. Results were similar for patients with both open and closed physes. Conclusions The KI is the most reliable patellar height measure for paediatric patients with TD, CP and SB, with either open or closed physes. The KI is more complex and experience may be important for valid, reliable measurement.
Tibial derotational osteotomies in two neuromuscular populations: Comparing cerebral palsy with myelomeningocele
Authors: Thompson R. M. , Ihnow S. , Dias L. , Swaroop V. 
Published: July 2017

Purpose To review the outcomes of tibial derotational osteotomies (TDOs) as a function of complication and revision surgery rates comparing a cohort of children with myelodysplasia to a cohort with cerebral palsy (CP). Methods A chart review was completed on TDOs performed in a tertiary referral centre on patients with myelodysplasia or CP between 1985 and 2013 in patients aged > 5 years with > 2 years follow-up. Charts were reviewed for demographics, direction/degree of derotation, complications and need for re-derotation. Two-sample T-tests were used to compare the characteristics of the two groups. Two-tailed chi-square tests were used to compare complications. Generalised linear logit models were used to identify independent risk factors for complication and re-rotation. Results The 153 patients (217 limbs) were included. Average follow-up was 7.83 years. Overall complication incidence was 10.14%, including removal of hardware for any reason, with a 4.61% major complication incidence (fracture, deep infection, hardware failure). After adjusting for gender and age, the risk of complication was not statistically significantly different between groups (p = 0.42) nor was requiring re-derotation (p = 0.09). The probability of requiring re-derotation was 31.9% less likely per year increase in age at index surgery (p = 0.005). Conclusion With meticulous operative technique, TDO in children with neuromuscular disorders is a safe and effective treatment for tibial torsion, with an acceptable overall and major complication rate. The risk of re-operation decreases significantly in both groups with increasing age. The association between age at initial surgery and need for re-derotation should help guide the treatment of children with tibial torsion.
Strength and Rigidity Performance of Laminated Members Using Small-Diameter Logs
Authors: Ha Been , Jang Sang Sik , Ogawa Keita , Yamasaki Mariko , Sasaki Yasutoshi 
Published: July 2017

Abstract
Korea and other countries have a high ratio of small-diameter logs in the harvested log volume. Hence, using these small-diameter logs as structural materials is an important issue. The lumber obtained from small-diameter logs generally has small cross-section dimensions and is mostly juvenile wood, resulting in inferior strength performance. In this research, a laminating process was developed for effective utilization of small-diameter logs as structural materials, and eight types of laminated beams and eight types of laminated columns were manufactured by the vertical and horizontal laminations with square cross-section timber. The laminated members were composed of laminated square timber obtained from small-diameter logs and were reinforced by square timber or lamina obtained from large-diameter logs. The laminated members were evaluated for their bending and axial compression performance. As a result, the beam exhibited an increase in bending Young's modulus of 63 percent and bending strength of 77 percent. Additionally, the column's axial compression performance indicated a positive effect on compression Young's modulus, where a 158 percent increase was found. Furthermore, when Johnson's equation was used to determine the critical stress, the value was close to the yield stress. In contrast, Euler's equation led to overestimation of the capacity as the slenderness ratio became smaller, which indicated that the application of Johnson's equation may be preferable. Therefore, a combination of small-diameter logs and large-diameter logs provided increased strength and rigidity performance, indicating the possibility of an effective use of small-diameter logs.
Herramienta coaching como factor motivacional en la implementación de la NTC ISO 9001:2008 en el área de biblioteca de la Fundación Universitaria de Ciencias de la Salud (FUCS)
Authors: Rodríguez Ramírez Luz Andrea , Lombana Motta Aura Carolina 
Published: July 2017

<p>El mercado globalizado aumenta la exigencia para las organizaciones y estas deben cambiar para adaptarse al entorno; los cambios que requiere la organización, entendida como un sistema social, enfrentan la resistencia normal de las personas a cambiar sus hábitos y costumbres, para no salir de su zona de comodidad. Este artículo reseña la experiencia de implementación del sistema de gestión de la calidad NTC ISO 9001:2008 en la Fundación Universitaria de Ciencias de la Salud (FUCS), durante la cual se encontró reticencia por parte de las personas participantes. En el desarrollo de la investigación se presentaron herramientas para minimizar los factores que producen la resistencia al cambio y para facilitar la implementación de las prácticas, principios, estrategias y tecnologías de la gestión de la calidad, con base en la metodología coaching. Los resultados destacan la utilidad de esta metodología para que las personas involucradas potencialicen sus capacidades y reorienten su trabajo en torno a los objetivos que se desean alcanzar y entiendan al sistema de gestión no como una carga adicional sino como un instrumento que facilita la consecución de los objetivos organizacionales.</p>
Revisión de métodos para el monitoreo de biomasa y carbono vegetal en ecosistemas forestales tropicales
Authors: Fonseca William 
Published: July 2017

La cuantificación de la biomasa vegetal es clave para conocer el carbono almacenado por los ecosistemas forestales y, por ende, la capacidad de mitigación del cambio climático. Existen variedad de métodos para estimar la biomasa, muchos de ellos con pequeñas variaciones, por ejemplo, el tamaño y forma de las unidades de muestreo, la inclusión o no de algún componente del reservorio (hojas, ramas, raíces, necromasa), diámetro mínimo inventariado, entre otras. El objetivo del manuscrito es explicar los aspectos más importantes a considerar en el inventario de remociones, a partir del diseño de inventario (diseño estadístico, tamaño y forma de las unidades de muestreo, componentes de la biomasa a evaluar). En un segundo punto se trata el tema de la determinación de la biomasa aérea y de raíces, haciendo referencia al método directo o destructivo y a los métodos indirectos, en especial al uso de modelos matemáticos por su fácil aplicación y bajo costo; además se anotan algunos modelos para bosque natural y plantaciones. También se hace referencia al estudio de carbono en suelos, a los factores de expansión de biomasa y a cómo determinar el carbono en la biomasa. Se espera que estas notas faciliten la comprensión del tema y que sean de referencia para el establecimiento de esquemas de monitoreo, reporte y verificación.
La guerra global contra el terrorismo y el fin de Centroamérica
Authors: Herrera-Rodríguez Omar Santiago 
Published: July 2017

Con la declaración de la Guerra Global contra el Terrorismo en el 2002, el gobierno estadounidense cambió su estrategia de intervención política, económica y militar hacia el resto del mundo y, particularmente, hacia Centroamérica, modificando en consecuencia la conformación espacial de la región. Analizo en este ensayo, las principales políticas desarrolladas por el gobierno estadounidense hacia la región centroamericana en la década de los ochentas y noventas, las cuales generan una plataforma de preparación para esta guerra, con el fin de demostrar 1) cómo la Guerra Global contra el Terrorismo responde a la necesidad del capitalismo de contener los estallidos de crisis económicas cada vez más prolongadas, mediante la guerra total y la constitución de un enemigo total: el terrorismo y 2) cómo Mesoamérica es construida como respuesta de los intereses geopolíticos y económicos estadounidenses actuales.
Local dependence in bivariate copulae with Beta marginals
Authors: Koutoumanou Eirini , Wade Angie , Cortina-Borja Mario 
Published: July 2017

The local dependence function (LDF) describes changes in the correlation structure of continuous bivariate random variables along their range. Bivariate density functions with Beta marginals can be used to model jointly a wide variety of data with bounded outcomes in the (0,1) range, e.g. proportions. In this paper we obtain expressions for the LDF of bivariate densities constructed using three different copula models (Frank, Gumbel and Joe) with Beta marginal distributions, present examples for each, and discuss an application of these models to analyse data collected in a study of marks obtained on a statistics exam by postgraduate students.
KEBERLANJUTAN DAERAH PERLINDUNGAN LAUT BERBASIS MASYARAKAT Kasus DPL-BM Blongko-Minahasa Selatan, DPL-BM Pulau Sebesi, Lampung Selatan dan APL Pulau Harapan Kepulauan Seribu
Authors: Faiza Riana , Kusumastanto Tridoyo , Bengen Dietriech G. , Boer Mennofatria , Yulianda Fredinan 
Published: July 2017

Tujuan umum dari penelitian ini adalah untuk mengevaluasi efektivitas perlindungan laut di tiga lokasi. Tujuan khususnya adalah (1) untuk mengevaluasi keberlanjutan dari perlindungan laut, dan (2) untuk merumuskan langkah strategis untuk pengembangan perlindungan laut. Penelitian dilakukan di tiga lokasi, yaitu Desa Blongko, Propinsi Sulawesi Utara, Pulau Sebesi, Provinsi Lampung, dan Pulau Harapan, Provinsi DKI Jakarta. Pengumpulan data dilakukan pada bulan Juni sampai Desember 2007. Metode analisis terdiri dari (1) analisa sumber daya alam dengan analisis kuantitatif, dan analisa keberlanjutan oleh scaling multi dimensi analisis. Ada 32 atribut telah dianalisa untuk mengevaluasi keberlanjutan perlindungan laut di tiga lokasi. Dengan analisis leverage ditemukan atribut-atribut dengan sensitivitas yang tinggi yaitu kualitas terumbu karang dan ikan karang (ekologi dan lingkungan dimensi); kontribusi pendapatan, mata pencaharian alternatif dan efek ganda dari perlindungan laut (aspek hukum ekonomi dan sosial dimensi);, peraturan daerah dan internalisasi program untuk program pembangunan daerah (dimensi kebijakan); pedoman perlindungan laut, program berkelanjutan, peningkatan kapasitas, dan partisipasi lembaga non pemerintah (dimensi kelembagaan). Tittle: Sustainability of Community Based Management for Marine Protected Area :Cases of the DPL-BM Blongko-Minahasa Selatan, the DPL-BM Sebesi Island-Lampung Selatan and the APL Harapan Island-Kepulauan SeribuGeneral objective of this research was to evaluate the effectiveness of marine sanctuaries in three locations. Specifically of this research were to evaluate the sustainability of marine sanctuary, and to formulate the strategic action for developing of marine sanctuary. Research was conducted at three locations, Blongko in North Sulawesi Province, Sebesi Island in Lampung Province, and Harapan Island, in Jakarta Province. Data collection was conducted during June to December 2007. This research used quantitative analysis by applying natural resources and sustainability analysis through multi dimension scaling analysis. This research applied 32 attributes to evaluate the sustainability of marine sanctuaries in three locations. By analysis of these attributes, it founded the attribute with high sensitivity remains to quality of coral reef and fish coral (ecological and environmental dimension); contribution of income, alternative livelihood and multiplier effect of marine sanctuary (economic and social dimension); legal aspect, local regulation and internalization of the program to local development program (policy dimension); and guidelines of marine sanctuary, extension officer programs and capacity building, and participation of non government institution (institutional dimension).
ANALISIS EFISIENSI KREDIT MODAL VENTURA UNTUK NELAYAN PERIKANAN TANGKAP (Studi Kasus Nelayan di Kabupaten Tegal)
Authors: Nababan Benny Osta , Sari Yesi Dewita 
Published: July 2017

Penelitian ini bertujuan untuk mengetahui efisiensi relatif pemberian kredit modal ventura terhadap nelayan di Kabupaten Tegal yang melakukan penangkapan menggunakan alat tangkap cantrang. Data yang digunakan terdiri dari data primer dan sekunder. Data Envelopment Analysis (DEA) digunakan untuk mengetahui efisiensi relatif nelayan penerima kredit ventura dibandingkan nelayan bukan penerima. Analisis juga dikembangkan dengan menggunakan 2 skenario yaitu maksimisasi output dan minimisasi biaya. Hasil penelitian menunjukkan bahwa dengan menggunakan seluruh variabel input dan output, maka 6 dari 7 nelayan penerima kredit ventura efisien 100% dan hanya 2 nelayan responden tidak menerima kredit ventura yang memiliki efisiensi 100%. Berdasarkan skenario 1 dan 2, hanya 2 nelayan penerima kredit ventura yang mengalami efisiensi 100%; sedangkan yang lainnya berkisar antara 70% - 100%. Nelayan tidak menerima kredit ventura memiliki efisiensi < 70%. Pemberian kredit modal ventura dapat meningkatkan efisensi usaha perikanan tangkap terutama bagi nelayan yang melakukan penangkapan jauh dari pantai. Tittle: Efficiency analysis of Ventura Capital Credit for Fisher's Household (Case Study of Fishers in Tegal District)This research aimed to understand relative efficiency of the ventura credits to Tegal district's fishers whose cantrang fishing unit. This research used primary and secondary data and applied Data Envelopment Analysis (DEA) to find out relative efficiency of fisher who receive the ventura credit, and compare it with the fishermen without ventura credit. By using two scenarios of maximization output and minimization input, this research results show that using all output and input variables, six of seven fishers received ventura credit have a relative efficiency of 100% and only 2 fishers not received the ventura credit have relative efficiency 100%. Based on first and second scenarios, 2 fishers received ventura credit have a relative efficiency of 100% and others have a relative efficiency ranging from 70% to 100%. Fishers who are not received ventura credit have a relative efficiency less than 70%. Ventura credit enables to increase relative efficiency of fishers, especially for those who fishing beyond coastal area
DINAMIKA KETERKAITAN SEKTOR KELAUTAN DAN PERIKANAN DALAM PEREKONOMIAN INDONESIA, 1995-2005: Pendekatan Rasmussen's Dual Criterion
Authors: Tajerin Tajerin , Manadiyanto Manadiyanto , Sastrawidjaja Sastrawidjaja 
Published: July 2017

Kelautan dan perikanan merupakan sektor yang potensial sebagai tumpuan (prime mover) pembangunan ekonomi. Kajian ini dilakukan dengan tujuan mengetahui dinamika dan posisi keterkaitan sektor kelautan dan perikanan dalam perekonomian Indonesia. Data yang digunakan adalah data sekunder yang bersumber dari Tabel Input-Output Kelautan dan Perikanan Tahun 1995, 2000 dan 2005. Analisis keterkaitan dilakukan dengan menggunakan model Input-Output dengan pendekatan Rasmussen's Dual Criterion. Hasil kajian menunjukkan bahwa selama periode 1995-2005, indeks kepekaan dan daya penyebaran dari sub sektor yang tercakup dalam sektor kelautan dan perikanan mengalami kondisi yang dinamis. Selain itu, sub sektor – sub sektor tersebut selama periode analisis hanya menempati posisi dalam kelompok potensial dan kelompok kurang berkembang. Berkaitan dengan temuan ini, diperlukan dukungan kebijakan investasi, kebijakan iklim usaha dan kebijakan lainnya yang secara terintegrasi mampu meningkatkan keterkaitan sektor kelautan dan perikanan dengan lebih nyata dalam perekonomian Indonesia, sehingga posisinya meningkat menjadi sektor unggulan. Tittle: Linkages Dynamics of the Marine and Fisheries Sector in Indonesian Economics, 1995 2005:Rasmussen's Dual Criterion Approach.Marine and fisheries sector is emerging as a potential sector and prime mover for economic development. This study is an evaluation of the dynamics and linkages position of marine and fishery sector in Indonesia economy. This study used secondary data which are derived from Input-Output Tables of Marine and Fisheries in 1995, 2000 and 2005. It applied the Input-Output model with Rasmussen's dual Criterion approach for linkage analysis. The results showed dynamic situation of sensitivity and dispersion of marine and fisheries sector during period of 1995-2005, which can be categorized as a potential groups and less developed groups. This study found that the requirement of investment, business climate and other related policies to increase more significantly marine and fisheries sector in Indonesian economics, which lead to prime mover sector.