bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Quercetin Levels in the Ethanol Extract of Curry Leaves (Murraya koenigii L.) as a Potential Animal Feed using High-Performance Liquid Chromatography
Authors: Warsito Sunaryo Hadi , Lamid Mirni , Arif Mohammad Anam Al , Lokapirnasari Widya Paramita , Ayuti Siti Rani , Khairullah Aswin Rafif , Delima Mira , Hermawan Intan Permatasari , Gangil Rakhi , Ahmad Zaheer 
Published: September 2024

Abstract

Background: Curry leaf (Murraya koenigii) is a frequently used medicinal plant. The M. koenigii plant is a type of spice in the Rutaceae family. Curry leaf ethanol extract contains flavonoid compounds. Quercetin is a flavonol compound, a flavonoid derivative that has a 3-hydroxyflavone skeleton. There is a need to analyze the quercetin level in curry leaves utilizing high-performance liquid chromatography (HPLC).

Methods: This research was conducted from August to October 2023. A total of 500 g of powdered curry leaves were placed in a maceration vessel. The liquid ethanol extract was mixed with the first re-maceration filtration product. Qualitative analysis was performed by comparing the retention time of the sample solution chromatogram with the reference standard solution of quercetin under identical HPLC conditions.

Results: The quantity of curry leave ethanol extract was 52.613 g. Analysis of the curry leaf extract samples revealed that sample 1 had a quercetin level of 0.080 mg/g, while sample 2 had a quercetin level of 0.079 mg/g. The final analysis of the curry leaf ethanol extract samples showed an average quercetin level of 0.03%.

Conclusion: These results indicate that the curry leave ethanol extract contains flavonoid compounds, especially quercetin.
Fatores associados ao óbito em pacientes com COVID-19 internados em Unidade de Terapia Intensiva Adulto
Authors: Generoso Gabriela Müller , Schmidt Catiele Raquel , Jesus Edna Ribeiro de , Boell Julia Estela Willrich , Fabrizzio Greici Capellari , Malkiewiez Michelle Mariah , Lorenzini Elisiane 
Published: September 2024

Objetivo: identificar os fatores associados ao óbito em pacientes diagnosticados com COVID-19 internados em unidade de terapia intensiva. Métodos: estudo transversal, com pacientes internados por COVID-19 em duas Unidades de Terapia Intensiva de dois hospitais públicos. Foi realizada coleta de dados em 222 prontuários eletrônicos e analisados por meio dos testes t de Student, Exato de Fisher, Qui-quadrado de Pearson e Regressão múltipla de Poisson com variância robusta. Resultados: prevaleceram pacientes do sexo masculino, com média de idade de 63,4±15,6 anos, cor branca (92,9%), casados ou com companheiro (64,6%), com escolaridade em nível de ensino fundamental (64,4%). Os fatores que impactaram de forma significativa sobre o desfecho óbito com maior razão de prevalência foram: dispneia com esforço respiratório (p=0,009), acometimento pulmonar-padrão tomográfico acima de 75% (p=0,006), insuficiência renal aguda com necessidade de hemodiálise (p=0,001) e pacientes acima de 65 anos (p=0,001). Conclusão: a idade foi identificada como principal fator independente para óbito. Contribuições para a prática: conhecer as características das hospitalizações em unidade crítica de pacientes com COVID-19 fornece subsídios para a prestação de cuidados de enfermagem qualificados, promovendo a segurança do paciente.
МОДЕРНІЗАЦІЙНА ПАРАДИГМА ЄВРОПЕЙСЬКОЇ ПОЛІТИКИ СІЛЬСЬКОГО РОЗВИТКУ: ІНСТИТУЦІЙНИЙ ПІДХІД, ВИКЛИКИ, ПЕРСПЕКТИВИ
Authors: ЗІНЧУК Тетяна , КОВАЛЬЧУК Олександр , УСЮК Тетяна 
Published: September 2024

Проаналізовано європейську політику сільського розвитку, яка пройшла тривалий період становлення і змін, що пов’язано з особливостями постійного реформування Спільної аграрної політики (САП) ЄС як базової для визначення цілей, пріоритетів і стратегій розвитку сільських територій, а також змін фокусів європейської регіональної політики. Узагальнено теоретичну базу категорії “сільський розвиток”, зокрема виділено методологічні підходи до дефініцій “село”, “сільські території”, “сільська місцевість”, розкрито сутність політики сільського розвитку з позиції її історичного внеску і доповнення до САП ЄС. Розглянуто концептуальні засади становлення політики сільського розвитку, які закладалися на різних етапах еволюції, визначали її роль і місце як “другого стовпа” САП ЄС. Відображено особливості та риси відмінності між політикою сільського розвитку і САП ЄС.
Обґрунтовано теоретико-пізнавальні, історичні та інституційно-практичні передумови формування поточних і майбутніх соціально-економічних стратегій європейської політики сільського розвитку. Оскільки сільська місцевість характеризується неоднорідністю видів економічної діяльності, різноманіттям природно-кліматичних умов, специфікою наявного ендогенного ресурсного потенціалу, проведено оцінку заходів, які забезпечують конкурентоспроможність сільських територій з посиленням акценту на розвиток соціальних інновацій і активізацію ініціативи громад.
Відображено особливості дії інституційних підходів ЄС щодо моніторингу, оцінювання і рекомендацій з реалізації Програм сільського розвитку, в тому числі на прикладі окремих країн –– членів ЄС. Виходячи з нових амбітних цілей ЄС щодо збереження і просування цінностей сільських територій досліджено механізм розподілу витрат, виокремлено прогресивні тенденції і пріоритети творення політики сільського розвитку на засадах сталості до 2040 р.
Are Child Access Prevention Laws Associated With Fewer Pediatric Firearm Injuries?
Authors: Wilson Emily G. , Gregoski Mathew J. , Oddo Elizabeth R. , Barfield William R. , Dow Matthew A. , Murphy Robert F. , Van Nortwick Sara S. 
Published: September 2024

OBJECTIVE
Firearm injuries are the leading cause of death for children in the United States. Child access prevention (CAP) laws have been passed in some states. This study examines characteristics of children with firearm injuries in states with different types of CAP laws.

METHODS
The Pediatric Health Information System database was reviewed to identify all pediatric firearm injury patients between 2016 and 2021. Hospital data were categorized based on state laws as (1) no CAP laws (2) some CAP laws or (3) strict CAP laws. CAP laws that specifically outlined criminal liability for the negligent storage of firearms were considered a strict restriction, whereas any other form of CAP law was considered some restriction. χ-squared and independent-samples median testing were performed to compare restriction levels.

RESULTS
Between 2016 and 2021, 12 853 firearm injuries were recorded in the Pediatric Health Information System database. In states with strict CAP laws, patients were significantly older (P &lt; .001) and had a significantly higher household income (P &lt; .001) compared with patients in states with no CAP laws. Gender, race, and the number of firearm injuries differed between the 3 restriction levels. There were less firearm injuries observed than expected in cities with strict CAP laws.

CONCLUSIONS
CAP laws are associated with a higher age and household income of pediatric firearm injury patients. Given the disparities seen between cities, a federal CAP law may best protect children nationwide.
Alpinia officinarum Hance extract relieved sepsis-induced myocardial ferroptosis and inflammation by inhibiting lncRNA MIAT/TRAF6/NF-κB axis
Authors: Shi Yao , Yang Xiaobo , Jiang Hong , Wu Shanxia , Hong Yan , Su Wei , Wang Xuan 
Published: September 2024

Sepsis is generally triggered by a dysfunctional host response to infection, and it can result in life-threatening organ dysfunction. Alpinia officinarum Hance (AO) exhibits regulatory functions in some diseases. However, whether AO extract (AOE) plays a promoting role in sepsis--triggered myocardial injury is unclear. This study was aimed at investigating the regulatory effects of AOE on myocardial ferroptosis and inflammation in sepsis, and the regulation effects on the lncRNA MIAT/TRAF6/NF-κB axis. Lipopolysaccharide (LPS) was used to treat mice for establishing an in vivo sepsis model. The pathological changes in heart tissues were observed through hematoxylin-eosin (HE) staining. The levels of CK-MB, cTnl, MDA, SOD, IL-1β, IL-18, IL-6, and TNF-α in serum were detected through enzyme-linked immunosorbent assay (ELISA). The level of Fe2+ was assessed, and the protein expressions (ACSL4, GPX4, TRAF6, p-P65, and P65) were examined through western blot. The expressions of lncRNA MIAT and TRAF6 were measured through real-time quantitative polymerase chain reaction (RT-qPCR). Our results demonstrated that AOE treatment ameliorated sepsis-triggered myocardial damage by reducing the disordered cardiomyocytes, the destroyed sarcolemma, and the CK-MB and cTnl levels. In addition, AOE treatment inhibited sepsis-induced myocardial ferroptosis and inflammation by regulating Fe2+, ACSL4, GPX4, IL-1β, IL-18, IL-6, and TNF-α levels. Moreover, the improvement effect of AOE was strengthened with the increase in the dose of AOE (25, 50, 100 mg/kg). It was also revealed that AOE treatment retarded the lncRNA MIAT/TRAF6/NF-κB axis. Rescue assays manifested that overexpression of MIAT reduced the cardioprotective effect of AOE. In conclusion, AOE relieved sepsis-induced myocardial ferroptosis and inflammation by inhibiting lncRNA MIAT/TRAF6/NF-κB axis. These findings may provide a potential therapeutic drug for the treatment of sepsis.
Quality Assurance Practices in Public Technical and Vocational Education and Training Institutions in the Khartoum State-Sudan
Authors: Gasmelseed Ahmed Mansour Mohammad 
Published: September 2024

The primary purpose of this study was to examine the quality assurance practice of public TVET institutions in Khartoum State and its challenges and prospects. To this end, the study used an explanatory sequential mixed method design. The researcher chooses 285 teachers and 491 students from 12 TVET institutions to complete the study questionnaire using stratified and simple random sampling. Descriptive (mean scores, standard deviation) and inferential statistics used to analyze quantitative data (two-sample t-test, multiple regression analysis). Also, the researcher interviewed all of the selected TVET institution managers, technical education directors, and SCVTA for qualitative data. Besides, six teachers and nine students participated in a focus group discussion, accompanied by an observational checklist for the quantity and quality of selected input resources. Documentary analyses for TVET policy documents were also used. According to the study's findings, the amount of materials and services available at Khartoum state TVET institutions is insufficient. In TVET institutions, the input quality was poor. Students had high expectations and perceptions of TVET. It was suggested that the authorities: formulate specific policies and plans for TVET, allocate the appropriate budget, and monitor the plan's implementation; form a collaboration between industry and TVET to help students and compensate for training deficiencies, and pay more attention to teacher training and motivation by meeting their needs.
Cyclosporine combined with eltrombopag for treatment of secondary graft failure after autologous hematopoietic stem cell transplantation
Authors: Semochkin S. V. , Lunin V. V. , Kaplanskaya I. B. , Fedenko A. A. 
Published: September 2024

Graft failure (GF) is an extremely rare complication of autologous hematopoietic stem cell transplantation (auto-HSCT) with a frequency not exceeding 3–5 % of all cases of this technology. Primary graft failure is distinguished when restoration of hematopoiesis has not occurred by day +28 after hematopoietic stem cell transfusion, and secondary GF, implying the occurrence of neutropenia <0.5 × 109 /L after successful initial engraftment, which cannot be explained by tumor relapse, infections or chemotherapy toxicity.In this report, we present a clinical case of a 57-year-old woman with newly diagnosed diffuse large B-cell lymphoma with multiple lesions of the skeletal bones and lymph node involvement on both sides of the diaphragm. A feature of this case of diffuse large B-cell lymphoma was the secretion of monoclonal IgGκ and plasmacytoid differentiation of tumor cells. Firstline therapy with 6 cycles of R-CHOP was unsuccessful. A complete metabolic response according to positron emission tomography combined with computed tomography (PET/CT) was obtained after 2 cycles of second-line R-DHAP therapy, followed by myeloablative consolidation and transfusion of 16.9 × 106/kg CD34+ autologous hematopoietic stem cells. The patient was discharged from the hospital on day +15 with stable restoration of hematopoiesis. The pancytopenia and aplasia of bone marrow hematopoiesis developed across 3 months after auto-HSCT. For secondary GF, the patient received G-CSF, transfusions of blood components, and treatment similar to that for aplastic anemia (cyclosporine 5 mg/kg plus eltrombopag). A partial hematological response was obtained within 9 months, and a complete response by 24 months of therapy. According to PET/CT data 36 months after auto-HSCT, the patient had a local increase in the level of 18F-fluorodeoxyglucose fixation (maximum standardized uptake value 3.33), possibly of an inflammatory nature, in the body of the L4 vertebra on the background of bone cement after vertebroplasty performed at the onset of the disease. In addition, monoclonal secretion of IgGκ persists in the absence of immunomorphological evidence of bone marrow involvement.In conclusion, the article discusses the possible causes of the monotonous monoclonal IgGκ secretion and presents a literature review of known GF treating methods.
Complement C3 inhibitor in patients with paroxysmal nocturnal hemoglobinuria with suboptimal response to C5 inhibitor therapy
Authors: Marchenko M. V. , Klimova O. U. , Anikina E. V. , Lapina A. V. , Rudakova T. A. , Ksenzova T. I. , Kulagin A. D. 
Published: September 2024

The introduction of the complement component C5 inhibitor eculizumab has radically changed the prognosis and quality of life of patients with paroxysmal nocturnal hemoglobinuria. Up to 30 % of patients develop only a suboptimal response to C5 inhibition. One reason for this is activation of extravascular hemolysis, due to opsonization of erythrocytes with fragments of the C3 component. Pegcetacoplan, the first ever registered C3 inhibitor, is aimed at solving this problem.In Russia, 2 patients received pegcetacoplan as part of a phase 3, randomized, open-label, active-comparator controlled trial PEGASUS. The analysis includes data from the first year of therapy: the run-in period (pegcetacoplan 1080 mg SC twice weekly in addition to the current dose of eculizumab, 4 weeks), the randomized controlled period (both patients were randomized to eculizumab monotherapy, 16 weeks), and the open-label period of pegcetacoplan therapy (32 weeks). Data from the extension study to evaluate the long-term safety and efficacy of pegcetacoplan are also presented. The duration of follow-up on pegcetacoplan therapy in both patients exceeded 4 years.
Treatment efficiency in patients with acute myeloid leukemia from 2019 to 2023 according to the Moscow Cancer Registry
Authors: Tolstykh T. N. , Misyurina E. N. , Mingalimov M. A. , Baryakh E. A. , Zhelnova E. I. , Gagloeva D. E. , Kardovskaya S. A. , Chudnova T. S. , Zotina E. N. , Ivanova D. D. , Kochneva O.  L. , Yatskov K. V. , Shimanovskaya L. T. , Mar’in D. S. , Makeshova A. B. , Chernova N. G. , Dudina G. A. , Granatkin M. A. , Semina T. A. , Misyurin A. V. , Lysenko M. A. 
Published: September 2024

Aim. To evaluate the acute myeloid leukemia (AML) treatment efficacy in adults in Moscow real clinical practice according to the Moscow Cancer Registry data.Materials and methods. We retrospectively collected data from the Moscow Cancer Registry on Moscow permanent residents who were primary diagnosed with AML from January 2019 to November 2023. The effectiveness of antitumor therapy was assessed by the complete remissions rate, relapses, deaths, and 3-year overall and relapse-free survival. Data analysis performed as of 01.12.2023.Results. According to the Moscow Cancer Registry, from 01.01.2019 to 01.12.2023, the diagnosis of AML (except for acute promyelocytic leukemia) was established in 752 patients with a median age at the time of diagnosis of 64 (19– 94) years. In the studied sample, females slightly predominated: women – 56.6 % (n = 426), men – 43.4 % (n = 326). Of all patients included in the study, 36 % (n = 275) received intensive chemotherapy, while 57 % (n = 427) received low-intensity chemotherapy, and the remaining 7 % (n = 50) patients received best supportive care. Early mortality (first 60 days) in the total group was 16 % (n = 123), 20 % (n = 149) of patients were refractory to the therapy. Complete remission was achieved by 63 % (n = 473) of patients: 82 % (n = 225) of them received intensive chemotherapy, 58 % (n = 248) – low-intensity chemotherapy. Relapses occurred in 41 % (n = 194) of 473 patients who achieved complete remission. In the first remission, allogeneic hematopoietic stem cell transplantation was performed in 11 % (n = 79) of patients. With a median follow-up of 30.1 months, the 3-year overall survival in total group was 27 % (95 % confidence interval 23–32), and the 3-year relapse-free survival was 44 % (95 % confidence interval 37–51).Conclusion. The main problem in the treatment of adult AML patients remains high induction mortality and limited opportunities for allogeneic hematopoietic stem cell transplantation in real clinical practice, which emphasizes the need to develop transplant centers in Moscow.
Indonesia Berpetualang ke Dunia Digital: Society 5.0
Authors: Ega Wijaya Mikel , Wibawa Aji 
Published: September 2024

Society 5.0 offers a platform where technology and innovation can enhance societal well-being by utilizing data and artificial intelligence to solve social issues. In the era of Society 5.0, Indonesia is faced with technology that enables virtual access as if it were physical access. AI based on big data and robots are utilized to support human labor in Society 5.0 technology. In this "new" world, digitalization, virtuality, and continuous internet access have become common for most of the world's population. In the face of the digital era and rapid technological advancements, Indonesia needs to take action. As a country with the world's largest population, it is crucial for Indonesia to utilize technology and innovation to improve the quality of life and societal well-being. Despite these challenges, Indonesia also has enormous potential to utilize technology and innovation in various sectors such as education, healthcare, and agriculture. Therefore, a joint effort between the government, industry, and society is needed to overcome these challenges and accelerate digital transformation in Indonesia to achieve maximum benefit from the potential of Society 5.0 in Indonesia.
Society 5.0 menawarkan di mana teknologi dan inovasi dapat meningkatkan kesejahteraan masyarakat dengan menggunakan data dan kecerdasan buatan untuk memecahkan masalah sosial. Dalam era Society 5.0, Indonesia berhadapan dengan teknologi yang memungkinan akses ke tempat virtual seakan-akan seperti akses ke tempat fisik. AI berbasis big data dan robot digunakan untuk memberikan dukungan pada pekerjaan manusia. dalam teknologi Society 5.0. Di dunia "baru" ini, digitalisasi, virtualitas, dan akses internet yang terus-menerus telah menjadi hal yang umum bagi sebagian besar populasi dunia. Di hadapan era digital dan perkembangan teknologi yang pesat, Indonesia perlu mengambil tindakan. Sebagai sebuah negara yang memiliki populasi jumlah penduduk terbesar di dunia, dalam memanfaatkan teknologi dan inovasi untuk meningkatkan kualitas hidup dan kesejahteraan masyarakatnya.Namun dibalik tantangan tersebut, Indonesia juga memiliki potensi besar pada pemanfaatan teknologi dan inovasi dalam berbagai sektor seperti pendidikan, kesehatan dan pertanian. Oleh karena itu, dibutuhkan upaya bersama antara pemerintah, industri, dan masyarakat untuk mengatasi tantangan tersebut dan mempercepat transformasi digital di Indonesia agar dapat meraih manfaat maksimal dari Potensi Society 5.0 di Indonesia.
Revelando o Invisível: as experiências de discriminação racial entre estudantes universitários
Authors: Oliveira Eliany Nazaré , Campos Marcos Pires , Pereira Paulo Jorge Almeida 
Published: September 2024

A discriminação racial pode ser definida como toda distinção, restrição, preferência ou exclusão baseada em raça, cor, descendência ou origem nacional ou étnica. O estudo teve como objetivo caracterizar as experiências de discriminação racial sofrida por estudantes aniversários. A amostra foi composta por 751 estudantes universitários de cinco instituições do ensino superior públicas e privadas do estado do Ceará. A coleta de dados foi realizada no período de junho a dezembro de 2023 de forma presencial e online. A escala de Experiência de Discriminação Racial foi o instrumento utilizado. A maioria dos participantes são sexo feminino 52,5%, se autodeclaram pardos 58,5%. Os homens revelaram ter sofrido mais discriminação do que as mulheres com 32,3%, também demonstraram mais preocupação quanto aos aspectos discriminatórios 40,9%. Em relação a resposta ao tratamento injusto, 75,9% das mulheres tentam fazer alguma coisa contra isto. Esses achados destacam a importância de abordar o racismo e suas consequências na vida dos estudantes universitários, bem como a necessidade de políticas e práticas que promovam a equidade e a justiça social nas universidades e na sociedade em geral.
Special Issue on Advanced Three-Dimensional Digital Geometry Processing
Authors: Nagai Yukie , Kanai Satoshi 
Published: September 2024

Geometry processing is a software technology that facilitates the appropriate and efficient conversion and processing of digital geometric data, including sampled points, curves, surfaces, images, and volumetric data, based on the intended application. It is a versatile technology and is increasingly adopted in diverse fields that rely on digital technologies and for the popularization of digital transition. Geometry processing is based on a robust and extensive mathematical framework that has been extensively investigated. As the scope of potential applications expands, the practical applications of these theories have increased accordingly. Geometry processing is currently employed for shape acquisition, analysis, design, and inspection in various fields, such as manufacturing, social infrastructure, medicine, natural science, and art. As the range of applications expands, several issues have emerged that require further investigation, such as increasing the accuracy and managing large-scale data.
The objective of this special issue is to provide new insights into geometric-processing capabilities. This issue comprises five papers that present novel aspects of this technology and two comprehensive reviews pertaining to aesthetic curves and related topics, as well as the applications of X-ray computed tomography (CT) in manufacturing. The papers included in this issue are as follows:
- Aesthetic curves and related geometries
- Object recognition from laser-scanned point cloud
- CAD data compression via wavelet transform
- Application of structure-from-motion
- Image analysis using Delaunay graphs
- Surface extraction from X-ray CT scan data
- Automation of manufacturing using X-ray CT scanning
The data types and methods used for geometry processing are diverse and depend on the scenarios. In this issue, we present a diverse range of studies pertaining to geometry processing that encompasses both fundamental concepts and applied studies.
We are grateful to all the contributors, reviewers, and editorial staff for their dedication and support in realizing this issue.