bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myelodysplastic and myeloproliferative disorders of childhood
Authors: Hasle Henrik 
Published: December 2016

AbstractMyelodysplastic syndrome (MDS) and myeloproliferative disorders are rare in children; they are divided into low-grade MDS (refractory cytopenia of childhood [RCC]), advanced MDS (refractory anemia with excess blasts in transformation), and juvenile myelomonocytic leukemia (JMML), each with different characteristics and management strategies. Underlying genetic predisposition is recognized in an increasing number of patients. Germ line GATA2 mutation is found in 70% of adolescents with MDS and monosomy 7. It is challenging to distinguish RCC from aplastic anemia, inherited bone marrow failure, and reactive conditions. RCC is often hypoplastic and may respond to immunosuppressive therapy. In case of immunosuppressive therapy failure, hypercellular RCC, or RCC with monosomy 7, hematopoietic stem cell transplantation (HSCT) using reduced-intensity conditioning regimens is indicated. Almost all patients with refractory anemia with excess blasts are candidates for HSCT; children age 12 years or older have a higher risk of treatment-related death, and the conditioning regimens should be adjusted accordingly. Unraveling the genetics of JMML has demonstrated that JMML in patients with germ line PTPN11 and CBL mutations often regresses spontaneously, and therapy is seldom indicated. Conversely, patients with JMML and neurofibromatosis type 1, somatic PTPN11, KRAS, and most of those with NRAS mutations have a rapidly progressive disease, and early HSCT is indicated. The risk of relapse after HSCT is high, and prophylaxis for graft-versus-host disease and monitoring should be adapted to this risk.
Reversal of direct oral anticoagulants: a practical approach
Authors: Shih Andrew W. , Crowther Mark A. 
Published: December 2016

Abstract
Direct oral anticoagulants (DOACs) have at least noninferior efficacy compared with other oral anticoagulants and have ancillary benefits, including overall better safety profiles, lack of the need for routine monitoring, rapid onset of action, and ease of administration. Reversal of these agents may be indicated in certain situations such as severe bleeding and for perioperative management. DOAC-associated bleeding should be risk stratified: patients with moderate or severe bleeding should have the DOAC discontinued and reversal strategies should be considered. Laboratory testing has limited utility in the acute management of bleeding; thrombin time and activated partial thromboplastin time may be useful for excluding clinically relevant levels of dabigatran. Prothrombin time is potentially useful for rivaroxaban and edoxaban, but calibrated anti-Xa assays are optimal for determining clinically relevant levels of factor Xa inhibitors. Because specific reversal agents are not widely available, supportive care and interventions for local hemostasis remain the cornerstones of therapy in the patient with DOAC-associated bleeding. Nonspecific reversal agents should be considered only in the event of severe bleeding because their efficacy is unknown, and they are associated with risk of thrombosis. Recent results from phase 3/4 studies demonstrate efficacy for an antidote to dabigatran (idarucizumab, a monoclonal antibody fragment with specificity for dabigatran) and an antidote to factor Xa inhibitors (andexanet alfa, a recombinant and inactive form of factor Xa that binds inhibitors). A universal reversal agent (ciraparantag) for many anticoagulants, including the DOACs, shows promise in results from phase 1 and 2 studies.
New challenges in evaluating anemia in older persons in the era of molecular testing
Authors: Steensma David P. 
Published: December 2016

Abstract
Anemia is common in older persons, and often remains unexplained despite a thorough clinical history, physical examination, and focused laboratory testing, including marrow aspiration, biopsy, and karyotyping. The advent of molecular genetic testing panels in hematology clinical practice has complicated the evaluation of older patients with unexplained anemia. While the presence of a somatic mutation provides evidence of clonal hematopoiesis and may support a diagnosis of a hematologic neoplasm such as one of the myelodysplastic syndromes (MDS), with rare exceptions, individual mutations are not strongly associated with one specific diagnosis, nor are they by themselves diagnostic of neoplasia. A clonal mutation in a patient with cytopenias and a nondiagnostic bone marrow may indicate a syndrome with a similar natural history to MDS, but at present there are no clear criteria to distinguish cytopenias coincidentally seen in association with an unrelated clonal mutation from cytopenias that are directly caused by that mutation. Ongoing and planned analyses will help define when mutation patterns alone can identify a disorder equivalent to a morphologically defined myeloid neoplasm such as MDS, further clarifying the etiology and natural history of unexplained anemia in the elderly.
Warm antibody autoimmune hemolytic anemia
Authors: Kalfa Theodosia A. 
Published: December 2016

AbstractAutoimmune hemolytic anemia (AIHA) is a rare and heterogeneous disease that affects 1 to 3/100 000 patients per year. AIHA caused by warm autoantibodies (w-AIHA), ie, antibodies that react with their antigens on the red blood cell optimally at 37°C, is the most common type, comprising ∼70% to 80% of all adult cases and ∼50% of pediatric cases. About half of the w-AIHA cases are called primary because no specific etiology can be found, whereas the rest are secondary to other recognizable underlying disorders. This review will focus on the postulated immunopathogenetic mechanisms in idiopathic and secondary w-AIHA and report on the rare cases of direct antiglobulin test–negative AIHA, which are even more likely to be fatal because of inherent characteristics of the causative antibodies, as well as because of delays in diagnosis and initiation of appropriate treatment. Then, the characteristics of w-AIHA associated with genetically defined immune dysregulation disorders and special considerations on its management will be discussed. Finally, the standard treatment options and newer therapeutic approaches for this chronic autoimmune blood disorder will be reviewed.
Second-line therapies in immune thrombocytopenia
Authors: Grace Rachael F. , Neunert Cindy 
Published: December 2016

Abstract
Immune thrombocytopenia (ITP) is a rare, acquired autoimmune condition characterized by a low platelet count and an increased risk of bleeding. Although many children and adults with ITP will not need therapy beyond historic first-line treatments of observation, steroids, intravenous immunoglobulin (IVIG), and anti-D globulin, others will have an indication for second-line treatment. Selecting a second-line therapy depends on the reason for treatment, which can vary from bleeding to implications for health-related quality of life (HRQoL) to likelihood of remission and patient preference with regard to adverse effects, route of administration, and cost. Published studies of these treatments are limited by lack of comparative trials, in addition to inconsistent outcome measures, definitions, and efficacy endpoints. This article provides an up-to-date comparison of the second-line treatments, highlighting important outcome measures including bleeding, HRQoL, fatigue, and platelet counts, which influence treatment selection in a shared decision-making model.
Aplastic anemia and clonal evolution: germ line and somatic genetics
Authors: Shimamura Akiko 
Published: December 2016

Abstract
Clonal progression to myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) remains a dreaded complication for a subset of patients with bone marrow failure (BMF). Recognizing risk factors for the development of MDS or AML would inform individualized treatment decisions and identify patients who may benefit from early or upfront hematopoietic stem cell transplantation. Now that next-generation DNA sequencing is available in the clinical laboratory, research has focused on the implications of germ line and somatic mutations for diagnosing and monitoring patients with BMF. Most germ line genetic BMF disorders are characterized by a high propensity to develop MDS or AML. Many affected patients lack the physical stigmata traditionally associated with the inherited marrow failure syndromes. Although any single inherited marrow failure disorder is rare, multiplexed genetic sequencing that allows simultaneous evaluation of marrow failure genes en masse demonstrated that, as a group, these inherited disorders compose a significant subset (5% to 10%) of patients with BMF. Early diagnosis of a germ line genetic marrow failure disorder allows individualized monitoring and tailored therapy. Recent studies of somatic variants in marrow failure revealed a high frequency of clonal hematopoiesis with the acquisition of mutations in genes associated with MDS or AML. Investigation of somatic mutations in marrow failure revealed important insights into the mechanisms promoting clonal disease but also raised additional questions. This review will focus on the evaluation and implications of germ line and somatic mutations for the development of clonal disorders in patients with BMF. Challenges and limitations of clinical genetic testing will be explored.
Team rivalry and lending on crowdfunding platforms: an empirical analysis
Authors: Ge Ling , Luo Xuechen 
Published: December 2016

Abstract
Background
Prosocial crowdfunding helps the underprivileged obtain non-profit seeking loans from multitudinous lenders. Some platforms introduce team competition to motivate member participation and may thus induce team rivalry.

Methods
We investigate how team rivalry affects lending decisions using data from Kiva.org. We argue that a rivalry relationship may engage teams to compete directly against rivals by lending to the same project or prevent them from doing so because they intend not to cooperate.

Result
We find that a team is less likely to lend to a project that has received funding from its rival team, suggesting that rival teams tend to avoid cooperation.

Conclusions
We discuss the implications of our findings for crowdfunding and competition-based motivation mechanisms in general.
Phosphorylation of filamin A regulates chemokine receptor CCR2 recycling
Authors: Pons Mònica , Izquierdo Ismael , Andreu-Carbó Mireia , Garrido Georgina , Planagumà Jesús , Muriel Olivia , del Pozo Miguel A. , Geli M. Isabel , Aragay Anna M. 
Published: December 2016

ABSTRACT
Proper endosomal trafficking of ligand-activated G-protein-coupled receptors (GPCRs) is essential to spatiotemporally tune their physiological responses. For the monocyte chemoattractant receptor 2 (CCR2B; one of two isoforms encoded by CCR2), endocytic recycling is important to sustain monocyte migration, whereas filamin A (FLNa) is essential for CCL2-induced monocyte migration. Here, we analyze the role of FLNa in the trafficking of CCR2B along the endocytic pathway. In FLNa-knockdown cells, activated CCR2B accumulated in enlarged EEA-1-positive endosomes, which exhibited slow movement and fast fluorescence recovery, suggesting an imbalance between receptor entry and exit rates. Utilizing super-resolution microscopy, we observed that FLNa–GFP, CCR2B and β2-adrenergic receptor (β2AR) were present in actin-enriched endosomal microdomains. Depletion of FLNa decreased CCR2B association with these microdomains and concomitantly delayed CCR2B endosomal traffic, without apparently affecting the number of microdomains. Interestingly, CCR2B and β2AR signaling induced phosphorylation of FLNa at residue S2152, and this phosphorylation event was contributes to sustain receptor recycling. Thus, our data strongly suggest that CCR2B and β2AR signals to FLNa to stimulate its endocytosis and recycling to the plasma membrane.
Product Line Bundling: Why Airlines Bundle High-End While Hotels Bundle Low-End
Authors: Shugan Steven M. , Moon Jihwan , Shi Qiaoni , Kumar Nanda S. 
Published: December 2016

Product lines are ubiquitous. For example, Marriott International manages high-end ultra-luxury hotels (e.g., Ritz-Carlton) and low-end economy hotels (e.g., Fairfield Inn). Firms often bundle core products with ancillary services (or add-ons). Interestingly, empirical observations reveal that industries with ostensibly similar characteristics (e.g., customer types, costs, competition, distribution channels, etc.) employ different bundling strategies. For example, airlines bundle high-end first class with ancillary services (e.g., breakfast, entertainment) while hotel chains bundle ancillary services (e.g., breakfast, entertainment) at the low-end. We observe, unlike hotel lines that are highly differentiated at different geographic locations, airlines suffer low core differentiation because all passengers (first-class and economy) are at the same location (i.e., same plane, weather, delays, cancellations, etc.). In general, we find product lines with low core differentiation (e.g., airlines, amusement parks) routinely bundle high-end while product lines with highly differentiated cores (e.g., hotels, restaurants) routinely bundle low-end. High-end bundling makes the high-end more attractive, increasing line differentiation (less intraline competition) while low-end bundling decreases line differentiation. Therefore, bundling allows optimal differentiation given a differentiation constraint (complex costs). Last, firms may use strategic bundling for targeting in their core products; e.g., low-end hotels bundle targeted add-ons unattractive to high-end consumers such as lower-quality breakfasts and slower Internet. Data, as supplemental material, are available at https://doi.org/10.1287/mksc.2016.1004 .
Target-Adjusted Utility Functions and Expected-Utility Paradoxes
Authors: Schneider Mark , Day Robert 
Published: December 2016

Experimental tests of expected-utility theory (EU) have accumulated empirical observations in which the predictions of EU are systematically violated. The cumulative prospect theory (CPT) explains violations such as the Allais paradoxes and fourfold pattern of risk attitudes as resulting from nonlinear probability transformations. Here we show that the classical paradoxes for decisions under risk can be explained with preferences that are linear in probabilities for any choice set and that maximize an expected-utility function with respect to an endogenous target return. We introduce the maximin payoff as a plausible and even natural target return from a choice set and show that the resulting target-adjusted utility (TAU) model explains additional empirical observations such as the scale dependence of the Allais paradox that cannot be explained by standard specifications of CPT. Further, using data from three prominent laboratory experiments, we find that TAU is effective in explaining observed behaviors. This paper was accepted by James Smith, decision analysis.
First Impressions Matter: An Experimental Investigation of Online Financial Advice
Authors: Agnew Julie R. , Bateman Hazel , Eckert Christine , Iskhakov Fedor , Louviere Jordan , Thorp Susan 
Published: December 2016

We explore how individuals assess the quality of financial advice they receive and how they form judgments about advisers. Using an incentivized discrete choice experiment, we show that first impressions matter: consumers more often follow advisers who dispense good advice before bad. We demonstrate how clients’ opinions of adviser quality can be manipulated by using an easily replicated confirmation strategy that depends on the quality of the advice and the difficulty and order of the advice topics. Our results also reveal how clients benefit from their own past experience and how they use professional credentials to guide their choices. Data, as supplemental material, are available at https://doi.org/10.1287/mnsc.2016.2590 . This paper was accepted by John List, behavioral economics.
Letters
Authors: Wren D. C. , Aquilina Natalie , Griffiths Glenys , Hill P. , Askew Susan , Waters Sue , Weir Mhairi , Ashdown J. , Gavin Anita , Johnson J. , Fry Carole , Minett E. E. , Pickett Heather , Charles Mandy , Dearden D.A. , MacKenzie R. , Steward S. A. , Ellis Veronica 
Published: December 2016

WHO HAS UPDATE ON RESEARCH EDUCATING DOCTORS A NATIONAL RESOURCE? A HOLISTIC APPROACH MORE SAMPLES NEEDED A USEFUL RESOURCE THE APPLIANCE OF SCIENCE WILL THE PRICE BE RIGHT? COMMUNITY NEEDS DISPARITY IN CARE BACK TO BASICS INFECTION MATTERS PREACHING TO THE CONVERTED? SUPPORT FOR STAFF A NURSE-LED DISCIPLINE INNOVATION NEEDED PRESCRIBING IMPLICATIONS
Impact of a Training Program on Pharmacists' Comfort with Pediatric Pharmacy Concepts and Basic Pediatric Knowledge
Authors: Riney Elizabeth A. , Crannage Andrew J. , Hasan Nausheen , Murphy Julie A. 
Published: December 2016

Objective To determine the impact of a training program on pharmacists' comfort with pediatric pharmacy concepts and basic pediatric knowledge. Methods All pharmacists at our institution were invited to participate in the study. Consenting participants completed a baseline survey of 15 questions on basic knowledge in 5 pediatric topic areas (pharmacokinetics/pharmacodynamics, weight-based dosing, anticoagulation, renal dosing, and common antibiotics) as well as 8 statements rating self-reported comfort with pediatric pharmacy. Following the pretraining survey, a training program combining self-study of handouts on the 5 topics with optional attendance at live education sessions was completed. Participants then completed a posttraining survey of the 5 topics including repeat comfort assessment. The primary outcome was change in self-assigned scores on the comfort-based assessment before and after training. Results Fifty-two pharmacists consented to participate. Participants reported significant improvement in 6 of 8 comfort questions after training ( p < .001). Those without prior pediatric experience had lower comfort ratings at baseline and showed significant improvement after training for 5 of the 8 questions ( p < .001). Significant improvement in the proportion of correct answers on the knowledge assessment occurred after training, regardless of prior experience (61% vs 89%, p < .001). Conclusions Self-study training with optional live education resulted in significant improvement in most self-reported comfort scores for pharmacists, particularly those without recent pediatric pharmacy experience. Pharmacists, regardless of experience, improved basic pediatric knowledge scores after training.
Inshore migration of tropical glass eels (Anguilla spp.) in Lambeso River, Aceh Jaya District, Aceh Province, Indonesia
Authors: Muchlisin Zainal A. , Maulidin Maulidin , Muhammadar Abdullah A. , Putra Dedi F. 
Published: December 2016

The objective of the present study was to evaluate the migration time of glass eels (Anguilla spp.) in the estuary of Lambeuso River, Aceh Jaya District, Indonesia. The survey was done in March and June 2015. The sampling location was determined based on an initial survey during February 2015 by considering the river condition. Based on initial survey there are no glass eels were recorded during noon time, and therefore the sampling was focused at night. The sampling was done four times a month (weekly basis) for three months (12 times in total) using trap nets based on Hijri Calendar. The trap was settled up to opposite direction of tide (seaward) from 18.00 PM to 06.00 AM and the catches glass eels were monitoring one-hour interval. A total of 131 glass eels were sampled during the study, where the samples were only caught on first (new month) and fourth week (old month) base on Hijri Calender during spring tide and no glass eels were sampled during second and third weeks. It was concluded that the migration time of the glass eels (Anguilla spp.) in Lambeso Rivers is during the dark moon at the new and old month of Hijri Calendar
Neue Wege der Informationsaggregation und -vernetzung – ein Blick hinter die Kulissen des Fachinformationsdienstes Darstellende Kunst
Authors: Beck Julia , Dörrer Axel , Knepper Marko , Voß Franziska 
Published: December 2016

Zusammenfassung:
Aus Sicht der FID-Projektgruppe werden einzelne Schritte zum Aufbau und der Entwicklung des Fachinformationsdienstes Darstellende Kunst geschildert. Insbesondere das Mapping der disparaten Datenmodelle aus Archiven, Bibliotheken, Museen- und Sammlungen der darstellenden Kunst in den Gesamtindex erwies sich als komplexer Arbeitsprozess. Die gelungene Migration der Daten in das FID-Portal www.performing-arts.eu führt zur Öffnung der proprietären Sammlungen in ein standardisiertes Austauschformat und ist ein wichtiger Schritt zur Erhöhung der Sichtbarkeit der Bestände zur darstellenden Kunst im Web.
On the fractional p-Laplacian equations with weight and general datum
Authors: Abdellaoui Boumediene , Attar Ahmed , Bentifour Rachid 
Published: December 2016

Abstract
The aim of this paper is to study the following problem:

\left\{\begin{aligned} \displaystyle(-\Delta)^{s}_{p,\beta}u&\displaystyle=f(x%
,u)&&\displaystyle\phantom{}\text{in }\Omega,\\
\displaystyle u&\displaystyle=0&&\displaystyle\phantom{}\text{in }\mathbb{R}^{%
N}\setminus\Omega,\end{aligned}\right.

where Ω is a smooth bounded domain of

{\mathbb{R}^{N}}

containing the origin,

(-\Delta)^{s}_{p,\beta}u(x):=\mathrm{PV}\int_{\mathbb{R}^{N}}\frac{\lvert u(x)%
-u(y)\rvert^{p-2}(u(x)-u(y))}{\lvert x-y\rvert^{N+ps}}\frac{dy}{\lvert x\rvert%
^{\beta}\lvert y\rvert^{\beta}}

with

{0\leq\beta<\frac{N-ps}{2}}

,

{1<p<N}

,

{s\in(0,1)}

, and

{ps<N}

.
The main purpose of this work is to prove the existence of a weak solution under some hypotheses on f. In particular, we will consider two cases:

(i)

{f(x,\sigma)=f(x)}

; in this case we prove the existence of a weak solution, that is, in a suitable weighted fractional Sobolev space for all

{f\in L^{1}(\Omega)}

. In addition, if

{f\gneq 0}

, we show that the problem above has a unique entropy positive solution.

(ii)

{f(x,\sigma)=\lambda\sigma^{q}+g(x)}

,

{\sigma\geq 0}

; in this case, according to the values of λ and q, we get the largest class of data g for which the problem above has a positive solution.
Asymptotic behavior of evolution systems in arbitrary Banach spaces using general almost periodic splittings
Authors: Kreulich Josef 
Published: December 2016

Abstract
We present sufficient conditions on the existence of solutions, with various specific almost periodicity properties, in the context of nonlinear, generally multivalued, non-autonomous initial value differential equations,

d
⁢
u

d
⁢
t

⁢

(
t
)

∈

A
⁢

(
t
)

⁢
u
⁢

(
t
)

,

t
≥
0

,

u
⁢

(
0
)

=

u
0

,

\frac{du}{dt}(t)\in A(t)u(t),\quad t\geq 0,\qquad u(0)=u_{0},

and their whole line analogues,

d
⁢
u

d
⁢
t

⁢

(
t
)

∈

A
⁢

(
t
)

⁢
u
⁢

(
t
)

{\frac{du}{dt}(t)\in A(t)u(t)}

,

t
∈
ℝ

{t\in\mathbb{R}}

,
with a family

{

A
⁢

(
t
)

}

t
∈
ℝ

{\{A(t)\}_{t\in\mathbb{R}}}

of ω-dissipative operators

A
⁢

(
t
)

⊂

X
×
X

{A(t)\subset X\times X}

in a general Banach space X.
According to the classical DeLeeuw–Glicksberg theory, functions of various generalized almost periodic types uniquely decompose in a “dominating” and a “damping” part.
The second main object of the study – in the above context – is to determine the corresponding “dominating” part

[

A
⁢

(
⋅
)

]

a

⁢

(
t
)

{[A(\,\cdot\,)]_{a}(t)}

of the operators

A
⁢

(
t
)

{A(t)}

, and the corresponding “dominating” differential equation,

d
⁢
u

d
⁢
t

⁢

(
t
)

∈

[

A
⁢

(
⋅
)

]

a

⁢

(
t
)

⁢
u
⁢

(
t
)

,

t
∈
ℝ

.

\frac{du}{dt}(t)\in[A(\,\cdot\,)]_{a}(t)u(t),\quad t\in\mathbb{R}.