bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rigidotubus tephroleucus gen. et sp. nov. (Cystostereaceae, Agaricales) evidenced by morphological characters and phylogenetic analyses
Authors: SONG JIE , XING JIA-HUI , JI XING , SUN YI-FEI , CUI BAO-KAI , DAI YU-CHENG 
Published: January 2018

A new poroid wood-inhabiting fungal genus, Rigidotubus, is proposed to accommodate R. tephroleucus sp. nov. based on morphological characters and molecular evidence. The genus is characterized by tough and poroid basidiomata, white to grayish white pore surface, white sterile margin, a monomitic hyphal system with clamped generative hyphae, ovoid to ellipsoid basidiospores negative in Melzer’s reagent and Cotton Blue. The phylogenetic analyses inferred from the internal transcribed spacer (ITS) and nuclear large subunit (28S) ribosomal RNA gene regions confirmed that Rigidotubus belongs to Cystostereaceae in Agaricales. A key to the accepted genera of Cystostereaceae is provided.
Reducing unnecessary culturing: a systems approach to evaluating urine culture ordering and collection practices among nurses in two acute care settings
Authors: Redwood Robert , Knobloch Mary Jo , Pellegrini Daniela C. , Ziegler Matthew J. , Pulia Michael , Safdar Nasia 
Published: January 2018

Abstract
Background
Inappropriate ordering and acquisition of urine cultures leads to unnecessary treatment of asymptomatic bacteriuria (ASB). Treatment of ASB contributes to antimicrobial resistance particularly among hospital-acquired organisms. Our objective was to investigate urine culture ordering and collection practices among nurses to identify key system-level and human factor barriers and facilitators that affect optimal ordering and collection practices.

Methods
We conducted two focus groups, one with ED nurses and the other with ICU nurses. Questions were developed using the Systems Engineering Initiative for Patient Safety (SEIPS) framework. We used iterative categorization (directed content analysis followed by summative content analysis) to code and analyze the data both deductively (using SEIPS domains) and inductively (emerging themes).

Results
Factors affecting optimal urine ordering and collection included barriers at the person, process, and task levels. For ED nurses, barriers included patient factors, physician communication, reflex culture protocols, the electronic health record, urinary symptoms, and ED throughput. For ICU nurses, barriers included physician notification of urinalysis results, personal protective equipment, collection technique, patient body habitus, and Foley catheter issues.

Conclusions
We identified multiple potential process barriers to nurse adherence with evidence-based recommendations for ordering and collecting urine cultures in the ICU and ED. A systems approach to identifying barriers and facilitators can be useful to design interventions for improving urine ordering and collection practices.
The lived experience of CrossFit as a context for the development of women’s body image and appearance management practices
Authors: Podmore Miranda , Ogle Jennifer Paff 
Published: January 2018

AbstractThe purpose of this interpretive study was to explore how women’s participation in the sport of CrossFit sets a context for the development of their body images—including their thoughts and feelings about the body and their lived experiences of embodiment—as well as their perceptions of culturally constructed ideals of beauty and gender. Analyses were informed by feminist cultural studies. In-depth, face-to-face interviews were conducted with 16 women who regularly participate in CrossFit. Data were analyzed using constant comparison processes. Findings illuminate how women experienced the culture of a male-owned, co-ed, CrossFit gym and how their immersion and participation in that gym culture gave rise to varied bodily experiences and practices, including body/appearance ideals, bodily appraisals, appetites and diets, physical fitness ideologies, appearance management routines, perspectives on gender, and identity development. Participant narratives revealed diverse lived realities across accounts as well as some evidence of contradiction or ambivalence within individual accounts. Implications for professionals who work in the body image area (e.g., nutritionists, counselors/therapists, sports psychologists), for the apparel and merchandising industry, for the sport of CrossFit, and for future work in the area are discussed.
Hope or hype in the treatment of schizophrenia – what's the role of the physician?
Authors: Bressan Rodrigo A. , Grohs Geder E. M. , Matos Gabriela , Shergill Sukhi 
Published: January 2018

SummaryAccording to the experience of people with schizophrenia, their psychiatrists' attitude towards the outcome of their illness is lacking in hope, which directly affects mutual faith in treatment. Here we discuss the scientific basis of hope and show its instrumental role in optimising the best treatment strategies for schizophrenia.Declaration of interestR.A.B has received honoraria for educational input and non-financial support from Ache; honoraria for educational input from Lundbeck; grants, honoraria for educational input and non-financial support from Janssen; all outside the submitted work. G.E.M.G. has received honoraria for educational input and non-financial support from Janssen outside the submitted work. G.M. reports support from Janssen-Cilag, outside the submitted work, and is an employee at Janssen-Cilag. S.S. has received grants and honoraria for educational input from EnVivo Pharmaceuticals, Takeda, AbbVie and Janssen Pharmaceuticals, outside the submitted work.
Embryo Implantation: War in Times of Love
Authors: Ashary Nancy , Tiwari Abhishek , Modi Deepak 
Published: January 2018

Abstract
Contrary to widespread belief, the implantation of an embryo for the initiation of pregnancy is like a battle, in that the embryo uses a variety of coercive tactics to force its acceptance by the endometrium. We propose that embryo implantation involves a three-step process: (1) identification of a receptive endometrium; (2) superimposition of a blastocyst-derived signature onto the receptive endometrium before implantation; and finally (3) breaching by the embryo and trophoblast invasion, culminating in decidualization and placentation. We review here the story that is beginning to emerge, focusing primarily on the cells that are in “combat” during this process.
Development and External Validation of Risk Scores for Cardiovascular Hospitalization and Rehospitalization in Patients With Diabetes
Authors: Yu Dahai , Cai Yamei , Graffy Jonathan , Holman Daniel , Zhao Zhanzheng , Simmons David 
Published: January 2018

Abstract

Context
Cardiovascular disease (CVD) is a common and costly reason for hospitalization and rehospitalization among patients with type 2 diabetes.

Objective
This study aimed to develop and externally validate two risk-prediction models for cardiovascular hospitalization and cardiovascular rehospitalization.

Design
Two independent prospective cohorts.

Setting
The derivation cohort includes 4704 patients with type 2 diabetes from 18 general practices in Cambridgeshire. The validation cohort comprises 1121 patients with type 2 diabetes from post-trial follow-up data.

Main Outcome Measure
Cardiovascular hospitalization over 2 years and cardiovascular rehospitalization after 90 days of the prior CVD hospitalization.

Results
The absolute rate of cardiovascular hospitalization and rehospitalization was 12.5% and 6.7% in the derivation cohort and 16.3% and 7.0% in the validation cohort. Discrimination of the models was similar in both cohorts, with C statistics above 0.70 and excellent calibration of observed and predicted risks.

Conclusion
Two prediction models that quantify risks of cardiovascular hospitalization and rehospitalization have been developed and externally validated. They are based on a small number of clinical measurements that are available for patients with type 2 diabetes in many developed countries in primary care settings and could serve as the tools to screen the population at high risk of cardiovascular hospitalization and rehospitalization.
Immunoexpression of P63 and SOX2 in triple-negative breast cancers, Indonesia
Authors: Kamarlis Reno K , Lubis Muhammad ND , Hernowo Bethy S , Kar Azmi S 
Published: January 2018

Background: Using immunohistochemical stains to target specific breast cancer markers has become indispensable for evaluation of small diagnostic tissue specimens, and therefore novel marker cocktails for specific breast cancers are required. This study was conducted to assess the immunoexpression of P63 and SOX2 in triple negative breast cancer (TNBC), and to evaluate the predictive diagnostic value of these markers for specific types of TNBC.Methods: Histological slides and paraffin blocks of TNBC cases were collected from Dr. Hasan Sadikin Hospital, Bandung, Indonesia from 5-years period (2011-2015). Each histological slide was subjected to immunohistochemical staining for P63 (nucleus and cytoplasm) and SOX2 (nucleus), with specific primer antibodies. Immunoexpression of P63 and SOX2 was evaluated using immunoreactivity scoring. Associations between P63 and SOX2 immunoexpression and TNBC types were assessed using Mann Whitney tests. In addition, the predictive diagnostic values of these markers were assessed.Results: Forty TNBC histological slides were included, and 23 (57.5%) were Basal-like type TNBC and 17 (42.5%) were Non basal-like type TNBC. Immunoexpression of P63 nucleus and SOX2 was not different between types of TNBC. However, immunoexpression of P63 in the cytoplasm in Basal-like type TNBC was significantly higher than in Non basal-like type TNBC (p=0.021). Predictor diagnostic value analysis suggested that immunoexpression of P63 in cytoplasm had 56.5% sensitivity and 70.6% specificity for diagnosing Basal-like type TNBC, with area under curve of 0.64. Conclusions: Immunoexpression of P63 in the cytoplasm has a relatively weak diagnostic value to discriminate Basal-like and Non basal-like types of TNBC.
Interventions to Reduce the Overuse of Imaging for Pulmonary Embolism: A Systematic Review
Authors: Deblois Simon , Chartrand‐Lefebvre Carl , Toporowicz Kevin , Chen Zhongyi , Lepanto Luigi 
Published: January 2018

BACKGROUNDImaging use in the diagnostic workup of pulmonary embolism (PE) has increased markedly in the last 2 decades. Low PE prevalence and diagnostic yields suggest a significant problem of overuse.PURPOSEThe purpose of this systematic review is to summarize the evidence associated with the interventions aimed at reducing the overuse of imaging in the diagnostic workup of PE in the emergency department and hospital wards.DATA SOURCESPubMed, MEDLINE, Embase, and EBM Reviews from 1998 to March 28, 2017.STUDY SELECTIONExperimental and observational studies were included. The types of interventions, their efficacy and safety, the impact on healthcare costs, the facilitators, and barriers to their implementation were assessed.DATA SYNTHESISSeventeen studies were included assessing clinical decision support (CDS), educational interventions, performance and feedback reports (PFRs), and institutional policy. CDS impact was most comprehensively documented. It was associated with a reduction in imaging use, ranging from 8.3% to 25.4%, and an increase in diagnostic yield, ranging from 3.4% to 4.4%. The combined implementation of a CDS and PFR resulted in a modest but significant increase in the adherence to guidelines. Few studies appraised the safety of interventions. There was a lack of evidence concerning economic aspects, facilitators, and barriers.CONCLUSIONSA combined implementation of an electronic CDS and PFRs is more effective than purely educational or policy interventions, although evidence is limited. Future studies of high‐methodological quality would strengthen the evidence concerning their efficacy, safety, facilitators, and barriers.
Visual Short-Term Memory Activity in Parietal Lobe Reflects Cognitive Processes beyond Attentional Selection
Authors: Sheremata Summer L. , Somers David C. , Shomstein Sarah 
Published: January 2018

Visual short-term memory (VSTM) and attention are distinct yet interrelated processes. While both require selection of information across the visual field, memory additionally requires the maintenance of information across time and distraction. VSTM recruits areas within human (male and female) dorsal and ventral parietal cortex that are also implicated in spatial selection; therefore, it is important to determine whether overlapping activation might reflect shared attentional demands. Here, identical stimuli and controlled sustained attention across both tasks were used to ask whether fMRI signal amplitude, functional connectivity, and contralateral visual field bias reflect memory-specific task demands. While attention and VSTM activated similar cortical areas, BOLD amplitude and functional connectivity in parietal cortex differentiated the two tasks. Relative to attention, VSTM increased BOLD amplitude in dorsal parietal cortex and decreased BOLD amplitude in the angular gyrus. Additionally, the tasks differentially modulated parietal functional connectivity. Contrasting VSTM and attention, intraparietal sulcus (IPS) 1–2 were more strongly connected with anterior frontoparietal areas and more weakly connected with posterior regions. This divergence between tasks demonstrates that parietal activation reflects memory-specific functions and consequently modulates functional connectivity across the cortex. In contrast, both tasks demonstrated hemispheric asymmetries for spatial processing, exhibiting a stronger contralateral visual field bias in the left versus the right hemisphere across tasks, suggesting that asymmetries are characteristic of a shared selection process in IPS. These results demonstrate that parietal activity and patterns of functional connectivity distinguish VSTM from more general attention processes, establishing a central role of the parietal cortex in maintaining visual information.SIGNIFICANCE STATEMENTVisual short-term memory (VSTM) and attention are distinct yet interrelated processes. Cognitive mechanisms and neural activity underlying these tasks show a large degree of overlap. To examine whether activity within the posterior parietal cortex (PPC) reflects object maintenance across distraction or sustained attention per se, it is necessary to control for attentional demands inherent in VSTM tasks. We demonstrate that activity in PPC reflects VSTM demands even after controlling for attention; remembering items across distraction modulates relationships between parietal and other areas differently than during periods of sustained attention. Our study fills a gap in the literature by directly comparing and controlling for overlap between visual attention and VSTM tasks.
Regulation of Lateral Hypothalamic Orexin Activity by Local GABAergic Neurons
Authors: Ferrari Loris L. , Park Daniel , Zhu Lin , Palmer Matthew R. , Broadhurst Rebecca Y. , Arrigoni Elda 
Published: January 2018

Orexin (also known as hypocretin) neurons are considered a key component of the ascending arousal system. They are active during wakefulness, at which time they drive and maintain arousal, and are silent during sleep. Their activity is controlled by long-range inputs from many sources, as well as by more short-range inputs, including from presumptive GABAergic neurons in the lateral hypothalamus/perifornical region (LH/PF). To characterize local GABAergic input to orexin neurons, we used channelrhodopsin-2-assisted circuit mapping in brain slices. We expressed channelrhodopsin-2 in GABAergic neurons (Vgat+) in the LH/PF and recorded from genetically identified surrounding orexin neurons (LH/PFVgat→ Orx). We performed all experiments in mice of either sex. Photostimulation of LH/PF GABAergic neurons inhibited the firing of orexin neurons through the release of GABA, evoking GABAA-mediated IPSCs in orexin neurons. These photo-evoked IPSCs were maintained in the presence of TTX, indicating direct connectivity. Carbachol inhibited LH/PFVgat→ Orx input through muscarinic receptors. By contrast, application of orexin was without effect on LH/PFVgat→ Orx input, whereas dynorphin, another peptide produced by orexin neurons, inhibited LH/PFVgat→ Orx input through κ-opioid receptors. Our results demonstrate that orexin neurons are under inhibitory control by local GABAergic neurons and that this input is depressed by cholinergic signaling, unaffected by orexin and inhibited by dynorphin. We propose that local release of dynorphin may, via collaterals, provides a positive feedback to orexin neurons and that, during wakefulness, orexin neurons may be disinhibited by acetylcholine and by their own release of dynorphin.SIGNIFICANCE STATEMENTThe lateral hypothalamus contains important wake-promoting cell populations, including orexin-producing neurons. Intermingled with the orexin neurons, there are other cell populations that selectively discharge during nonrapid eye movement or rapid eye movement sleep. Some of these sleep-active neurons release GABA and are thought to inhibit wake-active neurons during rapid eye movement and nonrapid eye movement sleep. However, this hypothesis had not been tested. Here we show that orexin neurons are inhibited by a local GABAergic input. We propose that this local GABAergic input inhibits orexin neurons during sleep but that, during wakefulness, this input is depressed, possibly through cholinergically mediated disinhibition and/or by release of dynorphin from orexin neurons themselves.
Retrosplenial Cortex Indexes Stability beyond the Spatial Domain
Authors: Auger Stephen D. , Maguire Eleanor A. 
Published: January 2018

Retrosplenial cortex (RSC) is highly responsive to landmarks in the environment that remain fixed in a permanent location, and this has been linked with its known involvement in scene and spatial processing. However, it is unclear whether RSC representations of permanence are a purely spatial phenomenon or whether they extend into behavioral and conceptual domains. To test this, during functional MRI scanning, we had people (males and females) read three different types of sentences that described either something permanent or transient. The first two sentence types were imageable, with a focus either on a spatial landmark or on an action. The third type of sentence involved non-imageable abstract concepts. We found that, in addition to being more active for sentences describing landmarks with a permanent location in space, RSC was also significantly engaged by sentences describing stable and consistent behaviors or actions, as long as they were rooted within a concrete imageable setting. RSC was not responsive to abstract concepts, even those that embodied the notion of stability. Similarly, it was not engaged by imageable sentences with transient contents. In contrast, parahippocampal cortex was more engaged by imageable sentences describing landmarks, whereas the hippocampus was active for all imageable sentences. In addition, for imageable sentences describing permanence, there was bidirectional functional coupling between RSC and these medial temporal lobe structures. It appears, therefore, that RSC-mediated permanence representations could be helpful for more than spatially mapping environments and may also provide information about the reliability of events occurring within them.SIGNIFICANCE STATEMENTThe retrosplenial cortex (RSC) is known to process information about landmarks in the environment that have a fixed, permanent location. Here we tested whether this permanence response was apparent beyond the spatial domain, which could have implications for understanding the role of the RSC more widely across cognition. We found that the RSC was engaged not only by permanent landmarks but also by stable and consistent actions. It was not responsive to transient landmarks or actions or to abstract concepts, even those that embodied the notion of stability. We conclude that the RSC might do more than help to map spatial environments, by possibly also providing information about the reliability of events occurring within them.
Cardiovascular Risk Factors After Adolescent Bariatric Surgery
Authors: Michalsky Marc P. , Inge Thomas H. , Jenkins Todd M. , Xie Changchun , Courcoulas Anita , Helmrath Michael , Brandt Mary L. , Harmon Carroll M. , Chen Mike , Dixon John B. , Urbina Elaine M. ,   for the Teen-LABS Consortium
Published: January 2018

BACKGROUND AND OBJECTIVES:
Severely obese adolescents harbor numerous cardiovascular disease risk factors (CVD-RFs), which improve after metabolic and bariatric surgery (MBS). However, predictors of change in CVD-RFs among adolescents have not yet been reported.

METHODS:
The Teen-Longitudinal Assessment of Bariatric Surgery study (NCT00474318) prospectively collected anthropometric and health status data on 242 adolescents undergoing MBS at 5 centers. Predictors of change in CVD-RFs (blood pressure, lipids, glucose homeostasis, and inflammation) 3 years after Roux-en-Y gastric bypass and vertical sleeve gastrectomy were examined.

RESULTS:
The mean (±SD) age of participants at baseline was 17 ± 1.6 years; 76% were girls, and 72% were white, with a median BMI of 51. Participants underwent Roux-en-Y gastric bypass (n = 161), vertical sleeve gastrectomy (n = 67), or adjustable gastric banding (n = 14). Increasing weight loss was an independent predictor of normalization in dyslipidemia, elevated blood pressure (EBP), hyperinsulinemia, diabetes, and elevated high-sensitivity C-reactive protein. Older participants at time of surgery were less likely to resolve dyslipidemia compared with younger participants, whereas girls were more likely than boys to demonstrate improvements in EBP. Even those participants without frank dyslipidemia or EBP at baseline showed significant improvements in lipid and blood pressure values over time.

CONCLUSIONS:
Numerous CVD-RFs improve among adolescents undergoing MBS. Increased weight loss, female sex, and younger age predict a higher probability of resolution of specific CVD-RFs. The elucidation of predictors of change in CVD-RFs may lead to refinements in patient selection and optimal timing of adolescent bariatric surgery designed to improve clinical outcomes.
Pediatric Sports- and Recreation-Related Eye Injuries Treated in US Emergency Departments
Authors: Miller Krystin N. , Collins Christy L. , Chounthirath Thitphalak , Smith Gary A. 
Published: January 2018

OBJECTIVES:
To investigate the epidemiologic characteristics of sports- and recreation-related eye injuries among children in the United States.

METHODS:
Data from the National Electronic Injury Surveillance System were analyzed in a retrospective study of children ≤17 years of age treated in US emergency departments for sports- and recreation-related eye injuries from 1990 to 2012.

RESULTS:
From 1990 through 2012, an estimated 441 800 (95% confidence interval: 378 868–504 733) children were treated in US emergency departments for sports- and recreation-related eye injuries, averaging 26.9 injuries per 100 000 children. Children 10 to 14 and 15 to 17 years old had the highest rate of eye injury. Three-fourths of injuries were sustained by boys. The most common types of injury were corneal abrasion (27.1%), conjunctivitis (10.0%), and foreign body in the eye (8.5%). Most eye injuries were treated and released (94.6%); however, 4.7% were hospitalized. The most common sports and recreation activities and equipment associated with eye injury were basketball (15.9%), baseball and softball (15.2%), and nonpowder guns (10.6%). The overall rate of eye injury decreased slightly during the study period; however, the rate of eye injury associated with nonpowder guns increased by 168.8%, and nonpowder gun-related eye injuries accounted for 48.5% of hospitalizations.

CONCLUSIONS:
Pediatric sports- and recreation-related eye injuries remain common. Increased prevention efforts are needed, especially for eye injuries associated with nonpowder guns. Increased child, parent, and coach education, as well as adoption of rules that mandate the use of eye protective equipment should be undertaken.