bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of the VASCADE® MVP venous vascular closure device in patients undergoing percutaneous left atrial appendage occlusion with WATCHMAN
Authors: Golzarian Hafez , Graebel Katherine T. , Bailey Rachel , Widmer Michael B. , Thiel Arielle , Hempfling Gerri , Otto Michael , Otto Todd , Patel Sandeep M. 
Published: September 2024

AbstractBackgroundThe VASCADE MVP venous vascular closure system is commonly used for percutaneous venotomy closure in catheter‐based procedures utilizing sheath sizes 6‐12 French. However, its application with larger sheaths such as ones required in left atrial appendage occlusion (LAAO) has yet to be explored.AimsThis study compared the efficacy and safety of VASCADE MVP versus conventional Figure‐of‐8 sutures (Fo8) for femoral venotomy closure in patients undergoing Watchman LAAO.MethodsThis single‐center retrospective analysis included patients who underwent post‐LAAO femoral venotomy closure with either VASCADE MVP or Fo8 sutures. The primary efficacy endpoint was time to hemostasis (TTH). Primary safety endpoints were 30‐day access site‐related readmissions and major complications. Minor access‐site‐related complications were also assessed.Results107 patients underwent post‐LAAO femoral venotomy closure with VASCADE MVP, of which 101 were successful (94.4%). 99 patients underwent conventional closure with Fo8 sutures and supplemental manual pressure. Baseline characteristics were similar between groups. TTH was significantly shorter with VASCADE MVP (152.9 vs. 335.8 s, p = 0.001). Major safety outcomes were comparable. However, the conventional group experienced a higher incidence of ecchymosis (16.2% vs 4.7%, p = 0.007) and 30‐day all‐cause readmission (18.2% vs 8.4%, p = 0.038).ConclusionsVASCADE MVP significantly reduced TTH compared to Fo8 sutures after LAAO. While demonstrating a similar safety profile, VASCADE MVP may offer a more efficient approach to femoral vein closure in this patient population.
The role of intra‐vascular imaging in patients undergoing intravascular lithotripsy: Insights from the COIL registry
Authors: Bawamia Bilal , Kuzemczak Michał , Lipiecki Janusz , Legutko Jacek , Bennett Johan , Dens Joseph , Alkhalil Mohammad 
Published: September 2024

AbstractBackgroundThe role of intra‐coronary imaging in patients with stent failure undergoing intravascular lithotripsy (IVL) is unclear. We aimed to assess clinical outcomes in patients undergoing IVL treatment for stent failure stratified according to the use of intra‐coronary imaging and lesion complexity.MethodsThis is a pre‐specified subgroup analysis of patients who were included in the coronary intravascular lithotripsy in patients with stent failure (COIL) registry (international multi‐centre study assessing IVL treatment for stent failure in 6 European centres). A complex lesion was defined if IVL treatment was used in the left main, true bifurcation, long lesion, or coupled with athero‐ablative therapy. The primary endpoint was the composite of cardiac death, spontaneous myocardial infarction, or target vessel revascularization (TVR) at 12 months.ResultsThere were 102 patients analyzed, of whom 27 (26%) patients had complex anatomy. The use of intra‐coronary imaging following IVL in stent failure was more frequent in patients with complex versus Noncomplex anatomy (56% vs. 31%, p = 0.022). IVL treatment was effective in both groups, however, patients with complex anatomy had worse clinical outcomes (30% vs. 11%, p = 0.02), driven by a higher rate of TVR (26% vs. 8%, p = 0.017). In the complex group, patients who underwent intracoronary imaging post intervention had lower event rate compared to those without imaging (13% vs. 50%, p = 0.038).ConclusionsIn patients undergoing IVL treatment for stent failure with complex coronary anatomy, the use of intra‐coronary imaging was associated with fewer adverse events compared to angiography guided intervention.
A study of case management challenge for black grain eumycetoma during the ongoing war in Sudan
Authors: Siddig Emmanuel Edwar , Aradaib Imadeldin E. , Ahmed Ayman 
Published: September 2024

Key Clinical MessageThis case highlights the significant challenges in the diagnosis and management of eumycetoma, particularly in regions like Sudan, where socioeconomic factors and ongoing conflict severely impact patient care. Delayed diagnosis and inadequate access to effective treatment can lead to poor adherence to prescribed therapies, prompting patients to resort to unproven self‐treatment methods. Comprehensive, multidisciplinary approaches that include education, improved accessibility to care, and addressing the impact of social determinants on health are essential to enhance the management of mycetoma, reduce disability rates, and improve patient outcomes in underserved communities.AbstractMycetoma is a chronic and debilitating infectious disease characterized by localized swellings and granulomatous lesions. It primarily affects individuals in tropical and subtropical regions and is caused by certain fungi or bacteria. This case report outlines the presentation, diagnosis, and management of a 37‐year‐old male from central Sudan with black grain eumycetoma, a challenging condition. The patient presented with recurring painless swelling in his right foot, which progressed over 5 years to include sinuses discharging black grain‐like materials. Despite initial treatment with itraconazole and folic acid, the patient discontinued medication due to war‐induced hardships including financial and accessibility to treatment and healthcare guidance, resulting in resorting to none‐effective and potentially harmful herbal remedies. Multidisciplinary management involving dermatologists, infectious disease specialists, and pharmacists supported with community health workers for health education is essential for enforcing adherence to treatment and successful recovery.
Numerical Analysis Selecting Chemical Mechanism of Ammonia–Hydrogen Mixture Laminar Burning Velocity by RMSE
Authors: Lu Yu Ying , Li Xinyang , Meir Herbert Une , Yang Guang Yu , Fan Yu Shuan , Cheng Way Lee , Chai Wai Siong 
Published: September 2024

AbstractThis study employs Cantera code to investigate the laminar burning velocity of different ammonia–hydrogen mixtures. Suitable models were selected from recent literature, and the one with the lowest root mean square error (RMSE) against experimental data was identified through the error function method. Bao mechanism shows an RMSE value of 4.71 at atmospheric pressure for ammonia–hydrogen mixtures, while the Otomo mechanism exhibits an RMSE of 2.11 under high‐pressure conditions. Additionally, sensitivity analysis was conducted to highlight critical reactions within each mechanism, emphasizing distinctions between different pressures. This approach aims to choose the proper mechanism to reduce computational and experimental costs in the early stages of ammonia–hydrogen research.
The Omega‐6 Lipid pathway shift is associated with neutrophil influx and structural lung damage in early cystic fibrosis lung disease
Authors: Slimmen Lisa JM , Broos Jelle Y , Manaï Badies HAN , Estevão Silvia C , Giera Martin , Kooij Gijs , Unger Wendy WJ , Janssens Hettie M 
Published: September 2024

AbstractObjectivesIn cystic fibrosis (CF), an imbalanced lipid metabolism is associated with lung inflammation. Little is known about the role that specific lipid mediators (LMs) exert in CF lung inflammation, and whether their levels change during early disease progression. Therefore, we measured airway LM profiles of young CF patients, correlating these with disease‐associated parameters.MethodsLevels of omega (ω)‐3/6 PUFAs and their LM derivatives were determined in bronchoalveolar lavage fluid (BALF) of children with CF ages 1–5 using a targeted high‐performance liquid chromatography–tandem mass spectrometry approach. Hierarchical clustering analysis was performed on relative LM levels. Individual relative LM levels were correlated with neutrophilic inflammation (BALF %Neu) and structural lung damage (PRAGMA‐CF %Disease). Significant correlations were included in a backward multivariate linear regression model to identify the LMs that are best related to disease progression.ResultsA total of 65 BALF samples were analysed for ω‐3/6 lipid content. LM profiles clustered into an arachidonic acid (AA)‐enriched and a linoleic acid (LA)‐enriched sample cluster. AA derivatives like 17‐OH‐DH‐HETE, 5‐HETE, 5,15‐diHETE, 15‐HETE, 15‐KETE, LTB4 and 6‐trans‐LTB4 positively correlated with BALF %Neu and/or PRAGMA %Dis. Contrastingly, 9‐HoTrE and the LA derivatives 9‐HoDE, 9(10)‐EpOME, 9(10)‐DiHOME, 13‐HoDE, 13‐oxoODE and 12(13)‐EpOME negatively correlated with BALF %Neu and/or PRAGMA %Dis. 6‐trans‐LTB4 was the strongest predictor for BALF %Neu. 5‐HETE and 15‐KETE contributed most to PRAGMA %Dis prediction.ConclusionsOur data provide more insight into the lung lipidome of infants with CF, and show that a shift from LA derivatives to AA derivatives in BALF associates with early CF lung disease progression.
Bayesian Individual Limits for IGF‐1 Monitoring in Equine Plasma: Implementation in the Equine Biological Passport
Authors: Barnabé Agnès , Loup Benoit , Cawley Adam , Delcourt Vivian , Garcia Patrice , Popot Marie‐Agnès , Keledjian John , Bailly‐Chouriberry Ludovic 
Published: September 2024

ABSTRACTDespite the International Federation of Horseracing Authorities (IFHA) regulation associated with heavy sanctions, the abuse of prohibited substances must be identified and deterred throughout horses' athletic careers, such as the administration of recombinant growth hormone (rGH). GH is naturally produced in mammal organisms to stimulate growth. Thus, rGH administration can enhance the performance of horses by expanding some physical abilities. As measuring endogenous GH levels is complex, an indirect strategy is to monitor GH‐associated biomarkers in plasma as insulin‐like growth factor 1 (IGF‐1) levels. To prevent these misuses, the Equine Biological Passport (EBP) has been designed in France (GIE LCH) and Australia (ARFL‐Racing NSW) to profile specific biological and chemical parameters in selected racehorses. In this study, we investigated individual limits as a complementary tool to a single limit to supervise the stability of IGF‐1 profile over a racing season. The aim is to design custom limits based on the horse's history to detect any deviation below the single limit. The method was assessed using experimental data and then tested on EBP data from three thoroughbreds and three French trotters. Finally, individual limits have been added to the French EBP for IGF‐1 monitoring.
Rapid Analytical Method for Quantification of Gamma‐Hydroxybutyrate (GHB) in Hair by UPLC‐MS/MS
Authors: Blanco‐Ces Miriam , de‐Castro‐Rios Ana , Lopez‐Rabuñal Angela , Cobo‐Golpe Maria , Cruz Angelines , Lendoiro Elena 
Published: September 2024

ABSTRACTGamma‐hydroxybutyrate (GHB), an endogenous compound related to the neurotransmitter gamma‐aminobutyric acid (GABA), is used as a therapeutic and recreational drug and as a “weapon” in drug‐facilitated crimes. The very short window of detection of GHB in conventional matrices (blood and urine) makes necessary the use of alternative matrices like hair. Hair has a long window of detection and the possibility to perform segmental analysis, which makes it very useful for proving GHB intake. In the present work, a method for quantification of GHB in hair was developed and validated. Hair (10 mg) was washed twice with dichloromethane and then incubated at room temperature with Milli‐Q water in an ultrasound bath for 30 min. Analysis was performed by UPLC‐MS/MS using a CORTECS UPLC HILIC (1.6 μm), 2.1 × 100‐mm column, and a gradient with acetonitrile and ammonium acetate (10 mM) at pH 6.0, with a total run‐time of 10 min. For detection, a triple quadrupole mass spectrometer in ESI negative mode was used. The method was validated, following the criteria established in the “AAFS Standard Practices for Method Validation in Forensic Toxicology” guideline, obtaining satisfactory results for linearity (0.5–50 ng/mg), accuracy (95.0%–103.2%), imprecision (< 10.2%), limit of detection (0.1 ng/mg) and quantification (0.5 ng/mg), exogenous selectivity (no interferences), matrix effect (less than −44.2%), extraction efficiency (> 86.4%), process efficiency (> 46.1%), and autosampler stability (< 4.3%). The method was used for the analysis of 26 authentic hair samples, 25 from non–drug users, obtaining values between < LOQ and 6.25 ng/mg of endogenous GHB and 1 from a former GHB chronic user to prove abstinence.
Fabrication of Hierarchically Porous “Fish Cage”‐like Carbonaceous Nanomaterials via Soft Template‐assisted Strategy for Cr Removal: Accelerated Stepped Adsorption and Enhanced Coordination Effect
Authors: Li Yan , Huang Yang , Pan Zhong , Ni Jiancong , Yang Weiqiang , Zhang Ying , Li Jianmin , Chen Xingmei , Yuan Xiao , Li Chunmei 
Published: September 2024

AbstractThe negative impact of heavy metal pollution, specifically chromium (VI), on human health is well‐documented. To solve this issue, hollow anisotropic hierarchically porous “Fish Cage”‐like carbonaceous nanomaterial (N,S‐HFC‐180) with multi‐active groups is synthesized. Hierarchically porous structure provides stepped adsorption effect. The addition of K2C2O4 leads to an increase in the specific surface area of N,S‐HFC‐180 to 1914.21 m2 g−1 (an increase of ~552 times compared to HFC‐180). Thiourea introduces multi‐active groups that act as “Barbs” in “Fish Cage”, further reducing Cr(VI) to Cr(III) and sequestrating Cr(III) by coordination effect. Subsequent batch studies suggest that N,S‐HFC‐180 exhibits a high removal capacity of 164.29 mg g−1 for Cr(VI) at pH=2. The kinetics and isotherm analyses display an outstanding maximum adsorption capacity of 393.88 mg g−1 at 298 K. In addition, even after seven cycles, the removal rate of Cr(VI) using N,S‐HFC‐180 remains>85.00 %, and it effectively reduces the concentration of electroplating wastewater from 55.82 to 0.14 mg L−1. Pore filling, chemical reduction and chelation, hydrogen bond and electrostatic attraction are the primary adsorption drivers. The results suggest that, the recoverable N,S‐HFC‐180 highlights its viability for practical applications in wastewater treatment processes.
Life's Essential 8, genetic susceptibility, and risk of incident pancreatic cancer: A prospective cohort study
Authors: Wu Zhuo , Zeng Liangtang , Fang Zhou , Yuan Yuan , Zhou Yu , Chen Rufu 
Published: September 2024

AbstractThe association between the American Heart Association (AHA) Life's Essential 8 (LE8) and the risk of pancreatic cancer (PC) remains unclear. Our goal was to assess the relationships between LE8, genetic susceptibility, and PC risk. This cohort consisted of 234,102 participants from the UK Biobank. The components of LE8 include diet, nicotine exposure, sleep, physical activity, blood glucose, body mass index, blood lipids, and blood pressure. LE8 is classified into three categories: low cardiovascular health (CVH), moderate CVH, and high CVH. Measurements were made using Cox proportional risk models to estimate impact of associations between LE8, genetic susceptibility, and incidence of PC in participants. Compared to participants with low LE8 scores, those with moderate and high LE8 scores had a 53% (HR, 0.47; 95% CI, 0.39–0.57) and 70% (HR, 0.30; 95% CI, 0.22–0.41) lower risk of developing PC, respectively. Interestingly, among individuals with high genetic risk, high LE8 scores were associated with greater benefits (HR, 0.24; 95% CI, 0.15–0.40), whereas the protective effect was weaker among those with low genetic risk (HR, 0.40; 95% CI, 0.21–0.75). Participants with a high LE8 score and a low polygenic risk score (PRS) had the lowest risk of PC (HR, 0.19; 95% CI: 0.11–0.33). Furthermore, we observed a significant additive interaction between LE8 and PRS. A higher LE8 score is associated with a lower risk of PC, especially for participants with a high PRS. These findings have important implications for participants most genetically predisposed to PC and for targeted strategies for PC prevention.
Extravascular lung water assessment by lung ultrasound in infants following pediatric cardiac surgery
Authors: Hubara Evyatar , Reynaud Stephanie , Gionfriddo Ashley , Runeckles Kyle , Mueller Brigitte , Floh Alejandro 
Published: September 2024

AbstractBackgroundLung edema is a significant factor in prolonged mechanical ventilation and extubation failure after cardiac surgery. This study assessed the predictive capability of point‐of‐care Lung Ultrasound (LUS) for the duration of mechanical ventilation and extubation failure in infants following cardiac procedures.MethodsWe conducted a prospective observational trial on infants under 1 year, excluding those with pre‐existing conditions or requiring extracorporeal membrane oxygenation. LUS was performed upon intensive care unit (ICU) admission and prior to extubation attempts. B‐line density was scored by two independent observers. The primary outcomes included the duration of mechanical ventilation and extubation failure, the latter defined as the need for reintubation or non‐invasive ventilation within 48 h post‐extubation.ResultsThe study included 42 infants, with findings indicating no correlation between initial LUS scores and extubation timing. Extubation failure occurred in 21% of the patients, with higher LUS scores observed in these cases (p = 0.046). However, interobserver variability was high, impacting the reliability of LUS scores to predict extubation readiness.ConclusionsLUS was ineffective in determining the length of postoperative ventilation and extubation readiness, highlighting the need for further research and enhanced training in LUS interpretation.
A comparison of the effects of nifedipine and indomethacin used in preterm labor tocolytic treatment on feto‐maternal Doppler ultrasonography flow
Authors: Isenlik Bekir Sitki , Sayal Hasan Berkan , Kaygun Bilgesu Cetinel , Turk Merve , Inal Hasan Ali 
Published: September 2024

AbstractObjectiveTo compare the effects of nifedipine and indomethacin, used for tocolytic purposes in the treatment of preterm labor (PTL), on fetal‐maternal Doppler blood flows and perinatal outcomes.Materials and MethodsEighty pregnant women between weeks 24 and 32 of gestation who used nifedipine (n = 40) and indomethacin (n = 40) as tocolytic treatments due to PTL were prospectively and consecutively included in the study. Sociodemographic, obstetric, and laboratory and Doppler flow parameters were compared between the groups.ResultsStatistically significant differences were observed between the groups in terms of gestational age at delivery and birth weight, Doppler flows (umbilical artery (UA) Pulsatility Index (PI), and UA Resistance Index (RI)) at 12, 24, and 48 h, middle cerebral artery RI at 12 h, and ductus venosus (DV) PI and DV‐RI at 12, 24, and 48 h (p < 0.05).ConclusionsThe findings of this study showed that nifedipine and indomethacin used in the treatment of PTL had significant effects on UA‐PI and UA‐RI Doppler flows at 12, 24, and 24 h, MCA‐RI Doppler flows at 12 h, and DV‐PI and DV‐RI Doppler flows at 12, 24, and 48 h. Further studies involving larger numbers of participants are now needed to support these results.
Incarceration of the gravid uterus: Ultrasound diagnosis and pregnancy outcomes
Authors: Zhang Meixiang , Luo Yingchun , Liu Dongmei , Peng Yulin , Hou Liqiong 
Published: September 2024

AbstractBackgroundThis research aims to summarize the ultrasound features and pregnancy outcomes of incarceration of the gravid uterus (IGU), providing a basis for clinical management.MethodsA retrospective cohort study was conducted on pregnant patients with IGU at Hunan Provincial Maternal and Child Health Care Hospital in China, spanning from September 30, 2016, to May 31, 2024. Data on maternal age, parity, medical history, risk factors, gestational age, clinical manifestations, ultrasound examination, treatment methods, time, and method for terminating pregnancy, and pregnancy outcomes were collected. We compared cases diagnosed before and after 20 gestational weeks.ResultsDuring the study period, 13 pregnant women were diagnosed with IGU, and 140 162 deliveries were recorded at our hospital. Two cases were referred from other hospitals and did not deliver in our hospital. Accordingly, the incidence of IGU was 0.08‰ (11/140, 162). The most prevalent risk factor for IGU was previous abdominal or pelvic surgery (61.54%, 8/13). Dysuria or even urinary retention was the primary symptom (38.46%, 5/13). Spontaneous resolution occurred in only one case (7.69%). All cases were detected using prenatal ultrasound examination with typical characteristics, including a retroverted uterus and the fundus located behind the cervix. No statistically significant differences between the two comparison groups were found in successful uterine reduction (p > 0.05).ConclusionThe definition of IGU should include symptomatic cases of any gestational age. Despite a low prevalence of this pregnancy complication, the overall prognosis of IGU is good. In the absence of severe symptoms, regular monitoring may be an option. Typical ultrasound imaging features enable a definitive diagnosis of IGU.
Sonographic findings associated with complications in pediatric patients with septic arthritis
Authors: Hosokawa Takahiro , Sato Yumiko , Tanami Yutaka , Oguma Eiji 
Published: September 2024

AbstractObjectivesUltrasound is a valuable tool for diagnosing septic arthritis and guiding the development of treatment plans. This study aimed to identify sonographic findings associated with complications in septic arthritis.MethodsTwelve patients aged <5 years diagnosed with septic arthritis were classified into two groups: those with and without complications. Complications were defined as the destruction of the epiphyseal bone head and metaphysis bone cortex. The following sonographic findings were compared between the two groups using Fisher's exact test: synovial membrane thickness, joint effusion, diminished hyperechoic foci within the epiphyseal bone head, and diminished smooth metaphyseal bone cortex.ResultsOverall, 4 of 12 patients developed complications. Joint effusion and synovial membrane thickening were detected in all patients with septic arthritis. The incidence of diminished hyperechoic foci within the epiphyseal bone head was significantly different between the two groups (presence/absence in patients with complications vs. without = 3/1 vs. 0/8, p = 0.018). The incidence of diminished smooth metaphyseal bone cortex was higher in patients with complications than in those without; however, this difference was not statistically significant (presence/absence in patients with complications vs. without = 4/0 vs. 3/5, p = 0.081).ConclusionUltrasound proved to be an effective diagnostic tool for septic arthritis and also demonstrated its potential in predicting complications of septic arthritis in the pediatric population.