bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Health-Seeking Behavior on Treatment Initiation of Cancer Patients at a Tertiary Care Hospital in Varanasi
Authors: Kesh Nishu , Pandey Manoj , Kansal Sangeeta 
Published: October 2024

Abstract

Background:
Cancer is one of the leading causes of death worldwide, and in order to prevent it, it is vital to understand cancer patients’ health-seeking behavior that contributes to patient delays in receiving cancer treatment globally; however, no similar studies have been conducted in India. Therefore, this study made an effort to know health-seeking behavior among delayed cancer patients receiving treatment at a tertiary care hospital, Varanasi.

Methods:
A cross-sectional study was conducted at the Department of Surgical Oncology OPD, Sir Sunder Lal Hospital, IMS, BHU, Varanasi. Randomly selected 440 registered patients were interviewed with the help of semi-structured questionnaire. Binary logistic regression analysis and 2-test were used in this study.

Results:
Out of total 440 patients included in this study, 207 (47.05%) were males and 233 (52.95%) were females. The majority (59.32%) of patients were more than 45 years of age group. Most (80%) of the patients had delay in cancer treatment of more than 60 days from onset of symptoms. Only 29.55% of patients were aware of any symptoms of Cancer. Those patients who were doing self-medication (P=0.03) and did not attend any cancer screening program (P=0.04) showed a statistically significant association with delayed initiation of treatment. Patients referred from another centre (P = 0.03) also show a significant association with delayed treatment initiation. Cancer patients who visited the screening program (AOR= 0.22, P=0.003) were significantly associated with a lower likelihood of delayed treatment initiation.

Conclusion:
The study showed that 80% of patients were delayed in seeking treatment for Cancer and highly influenced by low awareness, self-medication and visiting multiple health centres for diagnosis and treatment. Therefore, there is a strong need to address the reasons for the delay in seeking treatment.
Microneedling - A Novel Cosmetic Therapeutic Approach for Management of Gingival Hyperpigmentation and Review of Literature
Authors: Mangal Srashti , Lele Priya , Dodwad Vidya , Yewale Manasi 
Published: October 2024

Abstract
A beautiful smile boosts an individual’s self-confidence. The harmony of a smile depends on the shape, colour, and position of teeth, as well as the gingival tissue. Excessive gingival pigmentation is a major aesthetic concern for many people. Gingival hyperpigmentation is usually caused by an abnormal accumulation of melanin in the gingival tissue, which gives the gingiva a dark appearance. A variety of different modalities have been proposed for removing hyperpigmentation like Scalpel technique, LASER, Radiotherapy, Electrocautery, Bur abrasion, Chemical methods etc. Though the initial results of depigmentation procedures are promising, repigmentation is a common problem associated with them which poses a financial burden to the patient. To overcome this hurdle, a promising novel technique which is in vogue in cosmetic dermatology is Microneedling. Microneedling is a minimally invasive, cost effective, simple procedure that creates microholes to facilitate the penetration of topical medications across the connective tissues. The procedure activates the natural healing process, promoting the regeneration of epithelial cells and the breakdown of clusters of melanin pigment. This article gives an insight regarding microneedling technique and also discusses in depth regarding melanin synthesis, classification, indices, etiology, gingival depigmentation procedures, and repigmentation.
Surgical Management of Impacted Supernumerary Tooth and Odontome under General Anesthesia in an Emotionally Immature Child: A Case Report
Authors: Dua Rasleen , Vashisth Pallavi , Naik N. Sathyajith , De Sriparna 
Published: October 2024

Abstract
The disorder known as hyperdontia is characterized by an excess of teeth or teeth that appear to be added to the normal amount of teeth. With a frequency ranging from 0.1% to 3.9% in permanent dentition and from 0.3% to 1.8% in deciduous dentition, it affects males more often than women. Since children’s cognitive abilities are still developing in comparison to adults’, children freely communicate their worry and anxiety and frequently exhibit uncooperative behavior patterns while undergoing treatment. A 7-year-old child who was emotionally immature reported with a principal complaint of missing tooth in his left upper front tooth area for 2 years. Cone-beam computed tomography was advised to verify location and structural interaction with neighboring structures. Due to his lack of emotional sensitivity and cooperation with others, we planned the surgical extraction under general anesthesia. In the present case, it was deemed preferable to wait for a spontaneous eruption, and the patient was observed for a month on a regular basis.
Evaluation of the level of tumor necrosis factor-alpha and lactate dehydrogenase in acute lymphoblastic leukemia patients
Authors: Ahmed Raghad Yaarob , Al Hatem Zainab Issam 
Published: October 2024

Abstract:

BACKGROUND:
Acute lymphoblastic leukemia (ALL) is an abnormal clonal proliferation of early hemopoietic precursor cells in bone marrow (BM). There are certain cytokines like tumor necrosis factor alpha (TNF-α) which plays a crucial role in the development and progression of malignant process, and other enzymes like lactate dehydrogenase (LDH) which has prognostic value.

OBJECTIVE:
The aims of this study were to evaluate the level of serum TNF-α and LDH in ALL patients at diagnosis and post-induction chemotherapy.

PATIENTS, MATERIALS, AND METHODS:
This was an observational–analytical study, which was done in Ibn-Sina Teaching Hospital in the period between May 2023 and November 2023. It included 22 newly diagnosed patients with ALL. All patients underwent complete blood count, bone marrow examination, flowcytometry, serum TNF-α and LDH at diagnosis and post induction chemotherapy.

RESULTS:
In 22 patients with ALL, at diagnosis, the means of serum TNF-α (97.89 ± 52.945 ng/l), serum lactate dehydrogenase(1138.94 ± 430.10 IU/l), and percentage of blasts cells in BM (0.742 ± 0.181) in B-ALL. The means of serum TNF-α (165.33 ± 23.437 ng/l), serum lactate dehydrogenase (1633.33 ± 497.426 iu/l), and percentage of blasts cells in BM (0.816 ± 0.125) in T-ALL were statistically higher than those among the controls (s.TNF-a (18.09 ± 6.795 ng/l), s.LDH (142.59 ± 61.626 IU/l), and percentage of blasts cells in BM 0.0 ± 0.0) with P = 0.000 for all parameters mentioned, respectively. After induction phase chemotherapy in B-cell ALL , there were a significant reduction noted for serum TNF-α (29.26 ± 18.648 ng/l) and LDH levels (245.47 ± 154.592 IU/l) and a significant decrease in the percentage of blasts cells (0.07 ± 0.060).also in T-cell ALL there were a significant reduction noted for serum TNF-a (26.00 ± 11.135 ng/l) serum LDH (347.66 ± 160.300 IU/l) and percentage of blasts cells in bone marrow (0.06 ± 0.046). All of the postchemotherapy acute leukemia cases with lower TNF-α levels had complete remission (100%).

CONCLUSIONS:
There were significant increases in serum TNF-α and LDH in ALL patients at diagnosis; while after induction, there was a significant reduction in their levels. Complete remission from the disease was associated with lower levels of serum TNF-α in newly diagnosed patients.
Lysine (K)-specific methyltransferase 2A (KMT2A) rearrangements among Iraqi de novo acute myeloid leukemia
Authors: Al Jadir Riyam Qusay , Abdulameer Saba Abdulmahdi , Alalsaidissa Jaffar Nouri , AlJabban Ali 
Published: October 2024

Abstract:

BACKGROUND:
The classification of acute myeloid leukemia (AML) has evolved extensively over the last 20 years significantly, impacting the diagnosis and prognosis of the patients. The lysine (K)-specific methyltransferase 2A (KMT2A) gene, which has more than 80 gene fusions, is present in approximately 10% of all leukemias. Most KMT2A rearrangements are associated with adverse prognosis and need heavy chemotherapy protocol upfront.

OBJECTIVE:
This study aims to study the prevalence of KMT2A gene fusion among Iraqi patients with AML and its association with clinical and hematological parameters and patients’ outcomes.

PATIENTS, MATERIALS, AND METHODS:
A prospective cohort study conducted between December 2020 and May 2022 enrolled 115 Iraqi adults newly diagnosed with AML at the Hematology Unit of Baghdad Teaching Hospital. The patients were also monitored at this facility during the study period. Genetic rearrangements were detected using the Leukemia Q-Fusion Screening Kit through Real-Time Quantitative Reverse Transcription PCR (RT-qPCR) analysis.

RESULTS:
KMT2A rearrangements were identified in 23 (20%) patients. The most common was t(10;11) which presented in 15 (13%) patients, followed by t(9;11) in 5 (4.3%) patients and t(11;17) in 3 (2.6%) patients. Patients with KMT2A rearrangements were significantly older and more likely to have splenomegaly. At 1-month posttreatment, they had significantly lower red blood cell counts and hemoglobin levels and higher blast percentages. Only 4.3% achieved complete remission (CR) compared to 76.1% without KMT2A rearrangements, with a significantly higher mortality rate (30.4% vs. 5.4%, P = 0.0001). Regarding the treatment response, no significant differences were observed among the different fusion types of KMT2A rearrangements.

CONCLUSION:
KMT2A rearrangements are more prevalent among Iraqi AML patients compared to the global trend and are associated with older age, higher rates of splenomegaly, poorer hematological recovery, and worse outcomes, regardless of the KMT2A rearrangement fusion type.
EFL TEACHERS’ PERCEPTIONS OF LESSON STUDY IMPLEMENTATION IN SECONDARY RURAL SCHOOLS THROUGH THE INTERDISCIPLINARY APPROACH
Authors: Ichshanova Zhibek , Kassymova Gulnara , Amangazina Aizhan 
Published: October 2024

Lesson study approach is widely used in various countries to develop teachers’ pedagogical and instructional knowledge. The purpose of this study is to explore how Kazakhstani EFL teachers perceive the effectiveness of Lesson Study implemented through an interdisciplinary approach. Five EFL teachers from a secondary rural school who were the members of the interdisciplinary group of the Lesson Study participated in semi-structured interviews. The respondents indicated that the Lesson Study through the interdisciplinary approach had significantly improved their pedagogical and instructional knowledge. However, they also indicated that they experienced some challenges in the process, such as time consumption, observation of case students, and support from the administration of school.
The Performance of The Internal Audit Functions in Higher Education Institutions: The Auditees Perspective
Authors: Chenjerai Melania , Dubihlela Jobo , Makoza Frank , Le Roux Suzaan 
Published: October 2024

State-owned universities worldwide are facing challenges that cast doubt on the effectiveness of their internal audit departments. The objective of the study was to assess the current state of internal audit functions in terms of performance in Zimbabwe's higher education institutions. The research utilised a multi-case study approach, focusing specifically on state universities in Zimbabwe. Data was collected through a survey distributed to auditees in these state-owned universities and analysed the responses using multiple regression analysis. For rigor and robustness, the quantitative data was triangulated with the qualitative analysis of the auditor general reports covering the years 2013 to 2021. The qualitative findings showed that auditees generally lacked knowledge about the performance of internal audit functions in public universities. Further, the auditor general reports revealed the malpractices in state universities in the presence of internal auditors. The study recommends raising awareness about the importance of internal audit functions within university communities through training, education and displaying the internal audit charter on the university website. The auditor general must be proactive by conducting audits of the internal audit function in the state-owned universities. The lack of awareness about the internal audit function despite over a decade of existence in the ZSUs is an indication of the low value attached to the departments.
Aumentando la productividad en una empresa panificadora
Authors: Serrano C. , Alvarado E. , Turcios M. , Araya J. , Flores G. , Álvarez E. 
Published: October 2024

In a changing and competitive environment, companies must seek to increase the number of products withthe same resources, so this article has how to design different alternatives to increase productivity in the company "Charlotte Patisserie", first by carrying out a general investigation, then by doing data and analyzing them to culminate with the generation of the different improvement alternatives for the blueberry cheesecake star product, with the purpose of avoiding the interruption of work and optimizing the performance of the operators when collecting to prepare the desserts. The result obtained with the best alternative proposed was an increase in productivity of 12 % through the reduction of travel and operation times.

ILIA: Investigaciones Latinoamericanas en Ingeniería y Arquitectura, No. 01, 2024: 155-158.
Fanconi anemia diagnosed by genetic testing
Authors: Maarouf Fatima , Tazzite Amal , Berrada Sarah , Gazzaz Bouchaib , Dehbi Hind 
Published: October 2024

Background : Fanconi anemia (FA) is a rare genetic disorder inherited in an autosomal recessive manner. The clinical phenotype varies depending on the involvement of different genes. Major physical abnormalities mainly affect the limbs and spine.. Methods/Observation : We report the case of an 11-year-old girl from a first-degree consanguineous marriage. The classic triad of short stature, malformation syndrome and early bone marrow failure suggested AF, which was confirmed by the detection of significant chromosomal instability after culture with Mitomycin C, compared with a normal control. Conclusion : This case highlights the crucial role of cytogenetics in the diagnosis of Fanconi anemia and genetic counseling to improve the management of affected children and their families.
Keywords : Fanconi anemia; chromosomal breaks; mitomycin C.
Lightning Strike Danger Zone Detector System Integrated with Smartphone
Authors: Nugraha Adi , Al Bantani Rahmat Ato'ullah Gumilang , Grahito  , Yudono Muchtar Ali Setyo , Suryana Anang 
Published: October 2024

The potential for direct hits and bounces from buildings during thunderstorms can endanger pedestrians in the open area of the Faculty of Engineering Untirta campus. So far, there has been no danger warning in the open area so that pedestrians in the area are not prepared if unwanted things happen, especially when there is rain and lightning. Direct lightning strikes are one of the hydrometeorological events that need to be watched out for. Because of its impact that can cause damage to objects and casualties if exposed to humans. The campus area has a fairly large open area, making the threat of lightning strikes can occur at any time, especially during the rainy season. The purpose of this research is to design and implement a direct lightning strike hazard zone detection device in the campus area of the Faculty of Engineering UNTIRTA located in the city of Cilegon. The stages of research carried out include analyzing the open area of the FT campus using the Rolling sphere method. After that, plotting the area of the analysis results. Then an area detection tool was created which is categorized as a direct lightning strike danger zone that is integrated with Smartphone notifications.
Уголовная ответственность юридических лиц по законодательству Финляндской Республики
Authors: Федоров А.В. 
Published: October 2024

Статья посвящена законодательству Финляндии об уголовной ответственности юридических лиц. Рассматриваются вопросы формирования и развития уголовного законодательства Финляндии. Указывается, что уголовная ответственность юридических лиц в Финляндии установлена в 1995 г. путем внесения изменений в национальный уголовный кодекс и заключается в применении в судебном порядке к юридическому лицу за совершенное преступление уголовной санкции – корпоративного штрафа. Приводятся и анализируются общие условия применения к юридическим лицам корпоративного штрафа. Указываются юридические лица, признаваемые субъектами преступления и уголовной ответственности. Рассматриваются взаимосвязи между преступным деянием, совершенным физическим лицом, и уголовной ответственностью юридического лица; основания отказа от применения корпоративного штрафа к юридическому лицу; преступления, за совершение которых возможно привлечение к уголовной ответственности юридических лиц.
The article is devoted to the Finnish legislation on criminal liability of legal entities. The issues of formation and development of the criminal legislation of Finland are considered. It is indicated that the criminal liability of legal entities in Finland was established in 1995 by amending the national Criminal Code and consists of applying in court to a legal entity for a crime a criminal sanction – a corporate fine. The general conditions for applying a corporate fine to legal entities are given and analyzed. Legal entities recognized as subjects of crime and criminal liability are indicated. The article examines the relationship between a criminal act committed by an individual and the criminal liability of a legal entity, grounds for refusing to apply a corporate fine to a legal entity, crimes for which it is possible to bring legal entities to criminal responsibility.
Нарушения прав и законных интересов граждан или организаций либо охраняемых законом интересов общества или государства как общественно опасные последствия должностных злоупотреблений (ст. 285 и 286 УК РФ)
Authors: Иванов А.Л. , Савин П.Т. 
Published: October 2024

В статье рассматриваются вопросы нарушения прав и законных интересов граждан или организаций либо охраняемых законом интересов общества или государства как общественно опасных последствий некоторых должностных преступлений. Авторами статьи изучены работы ученых в области уголовного права, проанализирована следственно-судебная практика. В результате исследования они пришли к выводу о том, что отсутствие четких и определенных критериев понятия «существенное нарушение прав и законных интересов граждан или организаций либо охраняемых законом интересов общества или государства» в должностных злоупотреблениях (ст. 285 и 286 УК РФ) на практике приводит к спорам при квалификации содеянного следственными органами и противоречивым решениям судов. Решение обозначенной проблемы авторы статьи видят в том, чтобы содержание общественно опасного последствия в виде существенного нарушения прав и законных интересов граждан или организаций либо охраняемых законом интересов общества или государства определялось в зависимости от позиции высшего судебного органа по уголовным делам и высшего судебного органа конституционного контроля – Верховного Суда РФ и Конституционного Суда РФ. Соответствующие разъяснения указанных судов снимут существующие противоречия и позволят правоприменителю сформировать единообразное понимание указанных норм.
The article discusses issues of violation of the rights and legitimate interests of citizens or organizations or the legally protected interests of society or the state as socially dangerous consequences of certain malfeasance. The authors of the article studied the works of scientists in the field of criminal law and analyzed investigative and judicial practice. As a result of the study, they came to the conclusion that the lack of clear and defined criteria for the concept of a significant violation of the rights and legitimate interests of citizens or organizations or the legally protected interests of society or the state in official abuses (Articles 285 and 286 of the Criminal Code of the Russian Federation) in practice leads to disputes in the qualification of the crime by investigative authorities and conflicting court decisions. The authors of the article see the solution to the identified problem in the fact that the content of a socially dangerous consequence in the form of a significant violation of the rights and legitimate interests of citizens or organizations or the legally protected interests of society or the state is determined depending on the position of the highest judicial body in criminal cases and the highest judicial body of constitutional control – the Supreme Court of the Russian Federation and the Constitutional Court of the Russian Federation. Appropriate clarifications from these courts will remove existing contradictions and allow the law enforcer to formulate a uniform understanding of the norms under consideration.
Legislative Purpose — The Unwritten Criterion in Classifying Goods: A Case Study of Israel Law
Authors: Wagner Omer 
Published: October 2024

The International Convention on the Harmonized Commodity Description and Coding System (HS Convention) or HS, which seeks to establish uniform rules for the classification of products for customs and indirect tax purposes, is considered a resounding success. Its main objective is to ensure that a given product is classified in the same way in all World Customs Organization (WCO) member countries. The HS Convention does not specify the duty rates on each product, leaving it to the discretion of the member states, nor does it consider the legislative purpose of each country — to tax or exempt a product. This paper examines the issue of legislative purpose and concludes that considering the domestic legislative purpose when classifying leads to a lack of uniformity in the classification method and undermines the principle underlying the HS Convention. The issue has not been widely discussed in the literature; therefore, this paper makes a novel contribution to the literature on this topic.
Pengembangan Perangkat Pembelajaran Model Discovery Learning Pada Materi Getaran Gelombang Dan Bunyi Untuk Meningkatkan Kemampuan Problem Solving
Authors: Mokodompit Dewi Shintia , Buhungo Trisnawaty J. , Odja Abdul Haris 
Published: October 2024

Penelitian ini dilakukan di SMP PGRI OTAM , bertujuan untuk menghasilkan perangkat pembelajaran fisika yang berkualitas denga mengguankan model discovery learning, perangkat yang dikembangkan menggunakan model 4D. Hasil penelitian menunjukkan bahwa perangkat yang dikembangkan berkualitas. Perangkat pembelajaran dikatakan layak untuk digunakan dengan sedikit revisi, dilihat berdasarkan hasil rata-rata validasi dengan nilai 3,4–3,5, tingkat keefektifan perangkat pembelajaran dilihat dari peningkatan Pemecahan masalah (problem solving) peserta didik yang terdiri dari ranah kognitif diperoleh N Gain 0,54, dengan kriteria N gain sedang, ranah sikap dengan rata-rata presentase sebesar 81,02% serta rata-rata presentase pada ranah keterampilan 86,60% dan hasil pengamatan aktivitas peserta didik selama 3 kali pertemuan sebesar 79,66% dengan kriteria baik. Perangkat pembelajaran dikatakan praktis berdasarkan rata-rata presentase hasil keterlaksanaan pembelajaran selama 3 pertemuan sebesar 86,67.