bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in Fetal Growth Between 2000 to 2014 in Singleton Live Births from Israel
Authors: Agay-Shay Keren , Rudolf Mary , Rubin Lisa , Haklai Ziona , Grotto Itamar 
Published: January 2018

AbstractTrends in birthweight and abnormal fetal growth, namely term low birthweight (LBW), macrosomia, small-for-gestational age (SGA) and large-for-gestational age (LGA), are important indicators of changes in the health of populations. We performed this epidemiological study to evaluate these trends among 2,039,415 singleton live births from Israel over a period of 15 years. Birth certificate data was obtained from the Ministry of Health. Multivariable linear and logistic regression models were used to evaluate crude and adjusted estimates compared to the baseline of 2000 and polynomial trends. During the study period we observed a significant decrease in the rates of infants born SGA and LGA (10.7% to 9.2%, 10.2% to 9.6% respectively). After adjustment, based on the imputed data set, term mean birthweight increased by 6.0 grams (95% CI: 2.9, 9.1), and term LBW odds decreased by 19% in 2014 compared to 2000 (adj ORs: 0.81; 95% CI: 0.77, 0.85). Significant decreases were also observed for adjusted SGA, LGA and macrosomia rates. The decrease in abnormal fetal growth rates were not entirely explained by changes in sociodemographic characteristics or gestational age and may imply real improvement in child intrauterine growth in Israel during the last 15 years, especially in the Jewish population.
Contrasting patterns of prehistoric human diet and subsistence in northernmost Europe
Authors: Pääkkönen Mirva , Bläuer Auli , Olsen Bjørnar , Evershed Richard P. , Asplund Henrik 
Published: January 2018

AbstractCurrent archaeological evidence indicates the transition from hunting-fishing-gathering to agriculture in Northern Europe was a gradual process. This transition was especially complex in the prehistoric North Fennoscandian landscape where the high latitude posed a challenge to both domestic animal breeding and cereal cultivation. The conditions varied, the coastal dwellers had access to rich marine resources and enjoyed a milder climate due to the Gulf Stream, while those living in the inland Boreal forest zone faced longer and colder winters and less diversity in animal and plant resources. Thus, the coastal area provided more favourable conditions for early agriculture compared to those found inland. Interestingly, a cultural differentiation between these areas is archaeologically visible from the late 2nd millennium BC onwards. This is most clearly seen in regionally distinct pottery styles, offering unique opportunities to probe diet and subsistence through the organic residues preserved in ceramic vessels. Herein, we integrate the lipid biomarker, compound-specific stable carbon isotopes (δ13C), and zooarchaeological evidence to reveal culturally distinct human diets and subsistence patterns. In northern Norway, some of the coastal people adopted dairying as part of their subsistence strategy, while the inhabitants of the interior, in common with northern Finland, continued their hunter-gatherer-fisher lifestyles.
In situ formation of artificial moth-eye structure by spontaneous nano-phase separation
Authors: Li Tong , He Junhui , Zhang Yue , Yao Lin , Ren Tingting , Jin Binbin 
Published: January 2018

AbstractUnprecedented in situ formation of artificial moth-eye structure is demonstrated by spontaneous nano-phase separation of a silica-based system on substrate. The moth-eye thin film with a homogenously distributed nipples array shows broadband antireflection functionalities. The mechanism of nano-phase separation is unveiled as spinodal decomposition by chemical freezing method and thermodynamic analysis. The current method may provide a new avenue to ready fabrication of patterned nanostructures toward a variety of applications.
Climate Degradation and Extreme Icing Events Constrain Life in Cold-Adapted Mammals
Authors: Berger J. , Hartway C. , Gruzdev A. , Johnson M. 
Published: January 2018

AbstractDespite the growth in knowledge about the effects of a warming Arctic on its cold-adapted species, the mechanisms by which these changes affect animal populations remain poorly understood. Increasing temperatures, declining sea ice and altered wind and precipitation patterns all may affect the fitness and abundance of species through multiple direct and indirect pathways. Here we demonstrate previously unknown effects of rain-on-snow (ROS) events, winter precipitation, and ice tidal surges on the Arctic’s largest land mammal. Using novel field data across seven years and three Alaskan and Russian sites, we show arrested skeletal growth in juvenile muskoxen resulting from unusually dry winter conditions and gestational ROS events, with the inhibitory effects on growth from ROS events lasting up to three years post-partum. Further, we describe the simultaneous entombment of 52 muskoxen in ice during a Chukchi Sea winter tsunami (ivuniq in Iñupiat), and link rapid freezing to entrapment of Arctic whales and otters. Our results illustrate how once unusual, but increasingly frequent Arctic weather events affect some cold-adapted mammals, and suggest that an understanding of species responses to a changing Arctic can be enhanced by coalescing groundwork, rare events, and insights from local people.
Comprehensive list of SUMO targets in Caenorhabditis elegans and its implication for evolutionary conservation of SUMO signaling
Authors: Drabikowski Krzysztof , Ferralli Jacqueline , Kistowski Michal , Oledzki Jacek , Dadlez Michal , Chiquet-Ehrismann Ruth 
Published: January 2018

AbstractPost-translational modification by small ubiquitin-related modifier (SUMO) is a key regulator of cell physiology, modulating protein-protein and protein-DNA interactions. Recently, SUMO modifications were postulated to be involved in response to various stress stimuli. We aimed to identify the near complete set of proteins modified by SUMO and the dynamics of the modification in stress conditions in the higher eukaryote, Caenorhabditis elegans. We identified 874 proteins modified by SUMO in the worm. We have analyzed the SUMO modification in stress conditions including heat shock, DNA damage, arsenite induced cellular stress, ER and osmotic stress. In all these conditions the global levels of SUMOylation was significantly increased. These results show the evolutionary conservation of SUMO modifications in reaction to stress. Our analysis showed that SUMO targets are highly conserved throughout species. By comparing the SUMO targets among species, we approximated the total number of proteins modified in a given proteome to be at least 15–20%. We developed a web server designed for convenient prediction of potential SUMO modification based on experimental evidences in other species.
Magneto Acoustic Spin Hall Oscillators
Authors: Torunbalci Mustafa Mert , Gosavi Tanay Arun , Camsari Kerem Yunus , Bhave Sunil Ashok 
Published: January 2018

AbstractThis paper introduces a novel oscillator that combines the tunability of spin Hall-driven nano oscillators with the high quality factor (Q) of high overtone bulk acoustic wave resonators (HBAR), integrating both reference and tunable oscillators on the same chip with CMOS. In such magneto acoustic spin Hall (MASH) oscillators, voltage oscillations across the magnetic tunnel junction (MTJ) that arise from a spin-orbit torque (SOT) are shaped by the transmission response of the HBAR that acts as a multiple peak-bandpass filter and a delay element due to its large time constant, providing delayed feedback. The filtered voltage oscillations can be fed back to the MTJ via (a) strain, (b) current, or (c) magnetic field. We develop a SPICE-based circuit model by combining experimentally benchmarked models including the stochastic Landau-Lifshitz-Gilbert (sLLG) equation for magnetization dynamics and the Butterworth Van Dyke (BVD) circuit for the HBAR. Using the self-consistent model, we project up to ~50X enhancement in the oscillator linewidth with Q reaching up to 52825 at 3 GHz, while preserving the tunability by locking the STNO to the nearest high Q peak of the HBAR. We expect that our results will inspire MEMS-based solutions to spintronic devices by combining attractive features of both fields for a variety of applications.
Evidence of the Zanclean megaflood in the eastern Mediterranean Basin
Authors: Micallef Aaron , Camerlenghi Angelo , Garcia-Castellanos Daniel , Cunarro Otero Daniel , Gutscher Marc-André , Barreca Giovanni , Spatola Daniele , Facchin Lorenzo , Geletti Riccardo , Krastel Sebastian , Gross Felix , Urlaub Morelia 
Published: January 2018

AbstractThe Messinian salinity crisis (MSC) - the most abrupt, global-scale environmental change since the end of the Cretaceous – is widely associated with partial desiccation of the Mediterranean Sea. A major open question is the way normal marine conditions were abruptly restored at the end of the MSC. Here we use geological and geophysical data to identify an extensive, buried and chaotic sedimentary body deposited in the western Ionian Basin after the massive Messinian salts and before the Plio-Quaternary open-marine sedimentary sequence. We show that this body is consistent with the passage of a megaflood from the western to the eastern Mediterranean Sea via a south-eastern Sicilian gateway. Our findings provide evidence for a large amplitude drawdown in the Ionian Basin during the MSC, support the scenario of a Mediterranean-wide catastrophic flood at the end of the MSC, and suggest that the identified sedimentary body is the largest known megaflood deposit on Earth.
Characterization of a Novel Tectivirus Phage Toil and Its Potential as an Agent for Biolipid Extraction
Authors: Gill Jason J. , Wang Baixin , Sestak Emily , Young Ryland , Chu Kung-Hui 
Published: January 2018

AbstractThe oleaginous bacterium Rhodococcus opacus PD630 is metabolically diverse and can be cultivated on various renewable resources to serve as a sustainable triacylglycerol (TAG) feedstock for biodiesel production. Current methods for TAG extraction are costly, but infection of cultures by lytic bacteriophages (phages) may be a viable approach for achieving release of intracellular lipid from oleaginous bacteria such as R. opacus. This study reports the novel tectiviral phage Toil capable of releasing intracellular contents including a fluorescent protein marker and TAGs into the supernatant after phage infection of R. opacus PD631, a domesticated derivative of strain PD630. Phage Toil is placed in the Tectiviridae by its morphology, the presence of a lipid membrane, its genome architecture and the presence of terminal covalently-linked proteins. Toil is the first tectivirus capable of infecting a member of the Actinobacteria. Microscopy shows that infected cells do not undergo sudden lysis but instead maintain their original shape for several hours, with the cellular morphology gradually deteriorating. Approximately 30% of intracellular TAGs could be recovered from the culture supernatants of Toil-infected PD631 cells. Phage Toil has potential to be used as an agent in extraction of TAGs from oleaginous bacterium R. opacus. Importance: This study reported the first tectivirus (Phage Toil) capable of infecting a member of the Actinobacteria. In this study, we showed that Phage Toil can infect oleaginous bacterium Rhodococcus opacus to release intracellular contents such as a fluorescent protein marker and TAG lipid granules, which can serve as a starting material for biodiesel production. This study demonstrates a new method to extract TAGs by using this phage. Additionally, Phage Toil can be a new model phage to advance knowledge regarding phage infection mechanisms in Rhodococcus and other mycolic acid-containing bacteria such as Mycobacterium.
A Novel Modeling in Mathematical Biology for Classification of Signal Peptides
Authors: Ehsan Asma , Mahmood Khalid , Khan Yaser Daanial , Khan Sher Afzal , Chou Kuo-Chen 
Published: January 2018

AbstractThe molecular structure of macromolecules in living cells is ambiguous unless we classify them in a scientific manner. Signal peptides are of vital importance in determining the behavior of newly formed proteins towards their destined path in cellular and extracellular location in both eukaryotes and prokaryotes. In the present research work, a novel method is offered to foreknow the behavior of signal peptides and determine their cleavage site. The proposed model employs neural networks using isolated sets of prokaryote and eukaryote primary sequences. Protein sequences are classified as secretory or non-secretory in order to investigate secretory proteins and their signal peptides. In comparison with the previous prediction tools, the proposed algorithm is more rigorous, well-organized, significantly appropriate and highly accurate for the examination of signal peptides even in extensive collection of protein sequences.
An ethylene response factor (MxERF4) functions as a repressor of Fe acquisition in Malus xiaojinensis
Authors: Liu Wei , Wu Ting , Li Qiwei , Zhang Xinzhong , Xu Xuefeng , Li Tianhong , Han Zhenhai , Wang Yi 
Published: January 2018

AbstractIron (Fe) is an essential element for plants; however, its availability is limited as it forms insoluble complexes in the soil. Consequently, plants have developed mechanisms to adapt to low Fe conditions. We demonstrate that ethylene is involved in Fe deficiency-induced physiological responses in Malus xiaojinensis, and describe the identification of MxERF4 as a protein-protein interaction partner with the MxFIT transcription factor, which is involved in the iron deficiency response. Furthermore, we demonstrate that MxERF4 acts as an MxFIT interaction partner to suppresses the expression of the Fe transporter MxIRT1, by binding directly to its promoter, requiring the EAR motif of the MxERF4 protein. Suppression of MxERF4 expression in M. xiaojinensis, using virus induced gene silencing resulted in an increase in MxIRT1 expression. Taken together, the results suggest a repression mechanism, where ethylene initiates the Fe deficiency response, and the response is then dampened, which may require a transient inhibition of Fe acquisition via the action of MxERF4.
Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors
Authors: Mukherjee Sourav P. , Bondarenko Olesja , Kohonen Pekka , Andón Fernando T. , Brzicová Táňa , Gessner Isabel , Mathur Sanjay , Bottini Massimo , Calligari Paolo , Stella Lorenzo , Kisin Elena , Shvedova Anna , Autio Reija , Salminen-Mankonen Heli , Lahesmaa Riitta , Fadeel Bengt 
Published: January 2018

AbstractCarbon-based nanomaterials including carbon nanotubes (CNTs) have been shown to trigger inflammation. However, how these materials are ‘sensed’ by immune cells is not known. Here we compared the effects of two carbon-based nanomaterials, single-walled CNTs (SWCNTs) and graphene oxide (GO), on primary human monocyte-derived macrophages. Genome-wide transcriptomics assessment was performed at sub-cytotoxic doses. Pathway analysis of the microarray data revealed pronounced effects on chemokine-encoding genes in macrophages exposed to SWCNTs, but not in response to GO, and these results were validated by multiplex array-based cytokine and chemokine profiling. Conditioned medium from SWCNT-exposed cells acted as a chemoattractant for dendritic cells. Chemokine secretion was reduced upon inhibition of NF-κB, as predicted by upstream regulator analysis of the transcriptomics data, and Toll-like receptors (TLRs) and their adaptor molecule, MyD88 were shown to be important for CCL5 secretion. Moreover, a specific role for TLR2/4 was confirmed by using reporter cell lines. Computational studies to elucidate how SWCNTs may interact with TLR4 in the absence of a protein corona suggested that binding is guided mainly by hydrophobic interactions. Taken together, these results imply that CNTs may be ‘sensed’ as pathogens by immune cells.
Changes in cytokine responses to TB antigens ESAT-6, CFP-10 and TB 7.7 and inflammatory markers in peripheral blood during therapy
Authors: Leem Ah Young , Song Joo Han , Lee Eun Hye , Lee Hyejon , Sim Bora , Kim Song Yee , Chung Kyung Soo , Kim Eun Young , Jung Ji Ye , Park Moo Suk , Kim Young Sam , Chang Joon , Kang Young Ae 
Published: January 2018

AbstractMultiple cytokines and inflammatory markers control TB infection. We aimed to investigate the changes in multiple cytokines and inflammatory markers in active TB patients following anti-TB drug therapy. Twenty-nine patients with active TB were recruited prospectively between December 2010 and July 2017. Blood samples were collected before (T0), after 2 months (T2), and at the end of anti-TB treatment (Tend). We measured the levels of Interferon (IFN)-γ, interleukin (IL)-2, IL-12, IL-10, IL-13 and tumor necrosis factor (TNF)-α in supernatants collected from the QuantiFERON-TB Gold In-Tube assay (QFT-GIT), as well as the WBC, neutrophil, platelet count and neutrophil to lymphocyte ratio (NLR) in whole blood. Compared with baseline levels, WBC, neutrophil, and platelet counts were significantly lower following treatment. In addition, the NLR after treatment significantly decreased compared with baseline, whereas the IL-2/IFN-γ ratio increased after treatment. In conclusion, the levels of IL-2/IFN-γ ratios in the supernatant and the NLR might be useful biomarkers to evaluate the effectiveness of drug therapy in active TB patients.
The gamma gap predicts 4-year all-cause mortality among nonagenarians and centenarians
Authors: Yang Ming , Xie Linlin , Liu Xiu , Hao Qiukui , Jiang Jiaojiao , Dong Birong 
Published: January 2018

AbstractRecent studies have revealed the prognostic role of the gamma gap, the total serum proteins concentration minus the albumin concentration, for predicting all-cause mortality among adults. This study aims to investigate the relationship between the gamma gap and all-cause mortality among nonagenarians and centenarians via a secondary data analysis of a prospective observational study. The analysis included 801 participants (260 men and 541 women, mean age: 93.7 ± 3.5 years), 46 of which were lost at the 4-year follow-up. The mean gamma gap was 2.7 ± 0.5 g/dl. After adjusting for relevant confounders, the gamma gap was significantly associated with 4-year all-cause mortality (hazard ratio [HR] per 1-SD = 1.22, 95% confidential interval [CI]: 1.12–1.78). Using different cut-off points, the elevated gamma gap could be defined as ≥2.9, 3.0, 3.1, or 3.2 g/dl. The relevant HRs and 95% CIs of the elevated gamma gap for predicting mortality were 1.27 (1.12–1.90), 1.29 (1.03–1.78), 1.21 (1.23–1.66), and 1.26 (1.09–1.69), respectively. In conclusion, the gamma gap is an independent prognostic factor for long-term mortality in nonagenarians and centenarians. A value greater than or equal to 3.1 g/dl may define an elevated gamma gap, but further studies are required.
Two-color second-order sideband generation in an optomechanical system with a two-level system
Authors: Kong Cui , Li Sha , You Cai , Xiong Hao , Wu Ying 
Published: January 2018

AbstractSecond-order sideband generation in an optomechanical system with the coupling between a mechanical resonator and a two-level system is discussed beyond the conventional linearized description of optomechanical interactions. The features of two-color second-order sideband generation are demonstrated in this hybrid system. We discovery that the switch between one- and two-color second-order sideband generation is easily realized by shifting the detuning between the control field and the cavity field or the transition frequency of the two-level system. The efficiency of two-color second-order sideband generation increases monotonously with the control field strength. The coupling strength between the mechanical resonator and the two-level system plays a decisive role in the appearance of the two-color second-order sidebands. The two-color second-order sideband generation may provide measurement with higher precision in new degrees of freedom.
Triggering molecular assembly at the mesoscale for advanced Raman detection of proteins in liquid
Authors: Banchelli Martina , de Angelis Marella , D’Andrea Cristiano , Pini Roberto , Matteini Paolo 
Published: January 2018

AbstractAn advanced optofluidic system for protein detection based on Raman signal amplification via dewetting and molecular gathering within temporary mesoscale assemblies is presented. The evaporation of a microliter volume of protein solution deposited in a circular microwell precisely follows an outward-receding geometry. Herein the combination of liquid withdrawal with intermolecular interactions induces the formation of self-assembled molecular domains at the solid-liquid interface. Through proper control of the evaporation rate, amplitude of the assemblies and time for spectral collection at the liquid edge are extensively raised, resulting in a local enhancement and refinement of the Raman response, respectively. Further signal amplification is obtained by taking advantage of the intense local electromagnetic fields generated upon adding a plasmonic coating to the microwell. Major advantages of this optofluidic method lie in the obtainment of high-quality, high-sensitivity Raman spectra with detection limit down to sub-micromolar values. Peculiarly, the assembled proteins in the liquid edge region maintain their native-like state without displaying spectral changes usually occurring when dried drop deposits are considered.
Individuals with depressive tendencies experience difficulty in forgetting negative material: two mechanisms revealed by ERP data in the directed forgetting paradigm
Authors: Xie Hui , Jiang Donghong , Zhang Dandan 
Published: January 2018

AbstractAlthough previous studies have shown that individuals with depressive tendencies have deficits in forgetting negative material, the detailed underlying neural mechanisms have not been elucidated. This study examined the intentional forgetting of negative and neutral material in individuals with depressive tendencies in two phases. In the study phase, the participants performed a directed forgetting task, where a total of 320 words were presented to them, each followed by an instructive cue to forget or remember the previously presented word. Subsequently, in the memory recognition test phase, the participants completed the “old or new discrimination task”. The results indicated that individuals with depressive tendencies had difficulties suppressing the memory encoding of negative words, while the suppression of memory encoding of neutral words was relatively intact. Moreover, individuals with depressive tendencies displayed enhanced word-evoked P2 and late positive potential for negative items, as well as enhanced cue-evoked P1 and N2 for the negative items that were required to be forgotten, as compared to individuals without depressive tendencies. Based on these results, we propose two mechanisms that may contribute to the failure of forgetting negative material in mild depression: (1) inefficient memory suppression and early selective attention, and (2) excessive preliminary processing.