bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Media Pembelajaran EMI-PPKN Berbasis Digital Tematik Kelas V Sekolah Dasar
Authors: Santi Mega , Rizhardi Rury , Noviati Noviati 
Published: September 2024

Abstract: The development of thematic digital-based EMI-PPKN learning media for class V elementary schools, has the aim of knowing the development of valid and practical EMI-PPKN products. The type of research used by researchers in developing EMI-PPKN is R&D (Research and Development), development using the ADDIE model consisting of Analysis, Design, Development, Implementation, Evaluation. The subjects of this research were students in classes V.A and V.B at state elementary school 95 Palembang with a total of 35 students. The data collection techniques used in the research are observation, interviews, questionnaires, based on the results of research by validator experts from three fields, namely media, materials and language, where in this development there are 3 validators covering these 3 fields, so that the percentage of validators from the three experts is 90.83 % categorized as "Very Valid". Then the practicality test of the teacher's response obtained a percentage result of 86.66% categorized as "Very practical", then the one to one (Individual) trial obtained a percentage of 93.88% categorized as "Very practical", then the final trial, namely the small group, received a score percentage of 91.88% in the "Very practical" category.

Keywords: Learning Media Development, EMI-PPKN, Digital
Społeczności energetyczne z pakietu dyrektyw "Czysta energia dla wszystkich Europejczyków"
Authors: Długosz Tomasz 
Published: September 2024

W artykule omówiono obywatelskie społeczności energetyczne (CEC) i społeczności energetyczne działające w zakresie energii odnawialnej (REC), które regulowane są w prawie UC. Przedstawiono cele regulacji, idee stojące za społecznościami energetycznymi. Omówiono przyjęty model społeczności energetycznej, który został przyjęty w dyrektywach unijnych, oraz założenia dotyczące ram regulacyjnych, które państwa członkowskie mają wprowadzić. Zwrócono uwagę na zasadę zapewnienia równych szans społecznościom energetycznym na rynkach energii. W artykule wskazano wyzwania stojące przed regulacją społeczności energetycznych w prawie polskim i wywołano problem zmiany polskiego modelu regulacyjnego w zakresie, w jakim ten koncentruje się na regulacji zarobkowych przedsiębiorstw energetycznych.
Effects of Cerebellar Transcranial Direct Current Stimulation in Bilingual Logopenic Primary Progressive Aphasia
Authors: Coemans Silke , De Aguiar Vânia , Paquier Philippe , Tsapkini Kyrana , Engelborghs Sebastiaan , Struys Esli , Keulen Stefanie 
Published: September 2024

Background: Primary progressive aphasia (PPA) is a language-based dementia, causing progressive decline of language functions. Transcranial direct current stimulation (tDCS) can augment effects of speech-and language therapy (SLT). However, this has not been investigated in bilingual patients with PPA. Objective: We evaluated the case of Mr. G., a French (native language, L1)/Dutch (second language, L2)-speaking 59-year-old male, with logopenic PPA, associated with Alzheimer’s disease pathology. We aimed to characterize his patterns of language decline and evaluate the effects of tDCS applied to the right posterolateral cerebellum on his language abilities and executive control circuits. Methods: In a within-subject controlled design, Mr. G received 9 sessions of sham and anodal tDCS combined with semantic and phonological SLT in L2. Changes were evaluated with an oral naming task in L2, the Boston Naming Task and subtests of the Bilingual Aphasia Test in in L2 and L1, the Stroop Test and Attention Network Test, before and after each phase of stimulation (sham/tDCS) and at 2-month follow-up. Results: After anodal tDCS, but not after sham, results improved significantly on oral naming in L2, with generalization to untrained tasks and cross-language transfer (CLT) to L1: picture naming in both languages, syntactic comprehension and repetition in L2, and response times in the incongruent condition of the Attention Network Test, indicating increased inhibitory control. Conclusions: Our preliminary results are the first to indicate that tDCS applied to the cerebellum may be a valuable tool to enhance the effects of SLT in bilingual patients with logopenic PPA.
Vitamin D receptor polymorphisms associate with the efficacy and toxicity of radioiodine-131 therapy in patients with differentiated thyroid cancer
Authors: Deng Yuanhong , Fu Ying , Feng Ganghua , Zhang Yi 
Published: September 2024

BACKGROUND: Radioiodine-131 (I-131) therapy is the common postoperative adjuvant therapy for differentiated thyroid cancer (DTC) However, methods to evaluate the efficacy and toxicity of I-131 on DTC are still lacking. OBJECTIVE: To evaluate the association between vitamin D receptor (VDR) gene polymorphisms and the efficacy and toxicity of I-131 in DTC patients. METHODS: A total of 256 DTC patients who received I-131 therapy were enrolled. The patients were divided into effective group and ineffective group. 4 single nucleotide polymorphisms (SNPs) (rs7975232, rs731236, rs1544410 and rs10735810) of VDR were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) Cell counting kit-8 (CCK-8) and flow cytometry were used to detect the proliferation and apoptosis of thyroid cancer cells. RESULTS: Patients in effective group had more CC genotype of rs7975232 and GG genotype of rs10735810 compared with patients in ineffective group They were also independent factors for influencing the efficacy of I-131. PTC-1 and FTC-133 cells transfected with CC genotype of rs7975232 showed lower proliferative activity and higher apoptosis rate after being treated with I-131 In addition, patients with CC genotype at rs7975232 had fewer adverse reactions after I-131 treatment. CONCLUSIONS: VDR gene polymorphisms may be associated with the efficacy and toxicity of I-131 in DTC patients, which will help to personalize the treatment for patients.
Genetic association study of preterm birth and gestational age in a population-based case-control study in Peru
Authors: Juvinao-Quintero D.L. , Sanchez S.E. , Workalemahu T. , Pinto N. , Liang L. , Williams M.A. , Gelaye B. 
Published: September 2024

BACKGROUND: Preterm birth (PTB) affects ∼15 million pregnancies worldwide. Genetic studies have identified several candidate loci for PTB, but results remain inconclusive and limited to European populations. Thus, we conducted a genome-wide association study (GWAS) of PTB and gestational age at delivery (GA) among 2,212 Peruvian women. METHODS: PTB cases delivered≥20 weeks’ but < 37 weeks’ gestation, while controls delivered at term (≥37 weeks but <42 weeks). Multivariable regressions were used to identify genetic markers for PTB and GA (∼6 million SNPs), adjusting for maternal age and the first two genetic principal components. In silico functional analysis was conducted among top signals detected with an arbitrary P < 1.0×10–5 . We sought to replicate genetic markers for PTB and GA identified in Europeans, and we developed a genetic risk score for GA based on European markers. RESULTS: Mean GA was 30 ± 4 weeks in PTB cases (N = 933) and 39 ± 1 in the controls (N = 1,279). No associatiosn were identified at genome-wide level. Nominal PTB variants were enriched for biological pathways associated with polyketide, progesterone, steroid hormones, and glycosyl metabolism. Nominal GA variants were enriched in intronic regions and cancer pathways. Variants in WNT4 associated with GA in Europeans were replicated in our study. A genetic risk score was associated with a 2-day longer GA (P = 0.002) in our sample. CONCLUSIONS: This study identified various signals suggestively associated with PTB and GA in pregnant Peruvian women. None of these variants overlapped with signals previously identified in Europeans.
Impact of central vision loss on oculomotor skills required for reading: An eye-tracking study
Authors: González-Vides L. , Gómez-Pedrero J.A. , Cañadas P. , Hernández-Verdejo J.L. 
Published: September 2024

BACKGROUND A better understanding of the relationship between eye movements required for reading and central visual field loss may facilitate the design of more effective personalized visual rehabilitation programs to improve access to information and quality of life. OBJECTIVE To determine the impact of central vision loss due to maculopathy on the oculomotor skills required for reading and tasks of varying complexity, eye-tracking technology was used. METHODS Case-control study. Participants were 17 cases (61.7 years (SD [Formula: see text] 8.8), 12 females and 5 males) and 17 controls, matched for age and sex. Three computer-based tests were administered, analyzing eye fixations, saccadic movements, and visual search, measured with a 60 Hz eye-tracking device. RESULTS Central vision loss due to maculopathy increases the number of fixations and saccadic movements, indicating more instability in and out of the region of interest. Visual search required more fixations (16.2 [Formula: see text] 10.2 vs. 6.7 [Formula: see text] 1.9), more saccades (11.7 [Formula: see text] 6.4 vs. 3.3 [Formula: see text] 1.9), longer latency (701.3 [Formula: see text] 191.4 ms vs. 315.9 [Formula: see text] 56.0 ms), and longer time to find the target (113.1 [Formula: see text] 76.6 s vs. 18.5 [Formula: see text] 10.1 s). All comparisons between the two groups showed a statistically significant difference ([Formula: see text] 0.05). CONCLUSIONS The results revealed the significant impact of central vision loss due to maculopathy on reading by increasing patterns of eye fixations, saccadic movements, and visual search strategies, as measured by eye-tracking technology. This technology may have high potential to improve the assessment and rehabilitation of people with maculopathy, and this may become key information for designing personalized interventions to improve the quality of life and autonomy of individuals with central vision loss.
Empowering accessibility: The dynamics of assistive technology acquisition
Authors: Eshleman Julie , Moon Nathan , Harris Frances , Linden Maureen 
Published: September 2024

BACKGROUND While it has been broadly agreed that there is a need for consolidated information about assistive technology, previous attempts have not been sufficient for detailed consumer demands. OBJECTIVE Researchers sought consumer feedback to determine what should be included in a comprehensive, accessible database of AT. METHODS We conducted focus groups with different stakeholder groups (people with diverse disabilities, practitioners, and circles of support). We used a framework analysis to map participant responses to the research questions using focus group transcripts and notes. RESULTS AT users are looking for quick access to certain information such as the cost versus benefit, reliability, funding, and compatibility. They expect to find this in a variety of formats (video, audio, text) with a collaborative element (reviews and recommendations) from other users. CONCLUSIONS In an AT product database, users want the option to search by activity rather than only disability category, as disability can fluctuate. Accessibility of the database is key, with people preferring modifiable and flexible formats for both adding and consuming information. A community of practice will foster the connections people require to confirm their decisions prior to purchase.
Do dynamic changes in haematological and biochemical parameters predict mortality in critically ill COVID-19 patients?
Authors: Jandric Milka , Zlojutro Biljana , Momcicevic Danica , Dragic Sasa , Kovacevic Tijana , Djajic Vlado , Stojiljkovic Milos P. , Loncar-Stojiljkovic Dragana , Skrbic Ranko , Djuric Dragan M. , Kovacevic Pedja 
Published: September 2024

BACKGROUND: Critically ill COVID-19 patients are usually subjected to clinical, laboratory, and radiological diagnostic procedures resulting in numerous findings. Utilizing these findings as indicators for disease progression or outcome prediction is particularly intriguing. OBJECTIVES: Exploring the significance of dynamic changes in haematological and biochemical parameters in predicting the mortality of critically ill COVID-19 patients. METHODS: The present study was a prospective and observational study involving mechanically ventilated 75 critically ill adult COVID-19 patients with hypoxemic respiratory failure. The collected data included baseline patient characteristics, treatment options, outcome, and laboratory findings at admission and 7 days after. The dynamics of the obtained findings were compared between survivors and non-survivors. RESULTS: The 28-day survival rate was 61.3%. In the group of non-survivors significant dynamic changes were found for C-reactive protein ([Formula: see text] 0.001), interleukin-6 ([Formula: see text] 0.001), lymphocyte ([Formula: see text] 0.003), neutrophil-lymphocyte ratio ([Formula: see text] 0.003), platelets ([Formula: see text] 0.001), haemoglobin ([Formula: see text] 0.001), iron ([Formula: see text] 0.012), and total iron-binding capacity ([Formula: see text] 0.001). Statistically significant changes over time were found for ferritin ([Formula: see text] 0.010), D-dimer ([Formula: see text] 0.001), hs-troponin T ([Formula: see text] 0.002), lactate dehydrogenase ([Formula: see text] 0.001), glucose ([Formula: see text] 0.023), unsaturated iron-binding capacity ([Formula: see text] 0.008), and vitamin D ([Formula: see text] 0.001). CONCLUSION: The dynamic changes in inflammatory, haematological and biochemical parameters can predict disease severity, and outcome.
Periodontitis diagnosis: A review of current and future trends in artificial intelligence
Authors: Jundaeng Jarupat , Chamchong Rapeeporn , Nithikathkul Choosak 
Published: September 2024

BACKGROUND: Artificial intelligence (AI) acts as the state-of-the-art in periodontitis diagnosis in dentistry. Current diagnostic challenges include errors due to a lack of experienced dentists, limited time for radiograph analysis, and mandatory reporting, impacting care quality, cost, and efficiency. OBJECTIVE: This review aims to evaluate the current and future trends in AI for diagnosing periodontitis. METHODS: A thorough literature review was conducted following PRISMA guidelines. We searched databases including PubMed, Scopus, Wiley Online Library, and ScienceDirect for studies published between January 2018 and December 2023. Keywords used in the search included “artificial intelligence,” “panoramic radiograph,” “periodontitis,” “periodontal disease,” and “diagnosis.” RESULTS: The review included 12 studies from an initial 211 records. These studies used advanced models, particularly convolutional neural networks (CNNs), demonstrating accuracy rates for periodontal bone loss detection ranging from 0.76 to 0.98. Methodologies included deep learning hybrid methods, automated identification systems, and machine learning classifiers, enhancing diagnostic precision and efficiency. CONCLUSIONS: Integrating AI innovations in periodontitis diagnosis enhances diagnostic accuracy and efficiency, providing a robust alternative to conventional methods. These technologies offer quicker, less labor-intensive, and more precise alternatives to classical approaches. Future research should focus on improving AI model reliability and generalizability to ensure widespread clinical adoption.
Value of perfusion characteristics evaluated by CEUS combined with STQ parameters in diagnosing the properties of SLN in breast cancer
Authors: Tang Yizhi , Chen Peng , Tang Tian , Luo Zhihui , Wang Xuelian , Ma Xinxin , Jin Lijia 
Published: September 2024

BACKGROUND: Accurate sentinel lymph node (SLN) characterization is essential for breast cancer management, prompting advancements in imaging technologies such as contrast-enhanced ultrasound (CEUS) and sound touch quantification (STQ) to enhance diagnostic precision. OBJECTIVE: To explore the value of perfusion characteristics evaluated by CEUS combined with STQ parameters in diagnosing the properties of sentinel lymph node (SLN) in breast cancer. METHODS: A total of 91 breast cancer patients (91 SLNs) admitted to the hospital from February 2022 to December 2023 were selected for this study. Among them, 26 patients with metastatic SLN confirmed by surgery and pathology were included in the metastatic SLN group, and 65 patients with non-metastatic SLN were included in the non-metastatic SLN group. Preoperative examination results of CEUS and STQ were retrospectively analyzed. The diagnostic efficacy of perfusion characteristics evaluated by CEUS and STQ parameters for the properties of SLN in breast cancer was analyzed using the receiver operating characteristics (ROC) curve. Statistical methods such as chi-square tests and logistic regression analysis were employed to analyze the data. RESULTS: Enhancement patterns differed significantly between the metastatic SLN and non-metastatic SLN groups ([Formula: see text] 0.05). ROC curve analysis indicated that CEUS perfusion characteristics had an AUC value of 0.823 for diagnosing SLN properties, with a sensitivity of 84.62% and specificity of 70.77% using type I as the critical value. Additionally, STQ measurement showed significantly higher values in the metastatic SLN group (44.18 [Formula: see text] 6.53 kPa) compared to the non-metastatic SLN group (34.69 [Formula: see text] 6.81 kPa) ([Formula: see text] 6.075, [Formula: see text] 0.001). The AUC value for STQ parameters in diagnosing metastatic SLN was 0.849, with a sensitivity of 73.08% and specificity of 92.31% using 42.40 kPa as the critical value. Though the AUC value of STQ measurement was higher than CEUS perfusion characteristics alone, the difference was not statistically significant ([Formula: see text] 0.393, [Formula: see text] 0.695). Moreover, combining CEUS perfusion characteristics with STQ parameters yielded an AUC value of 0.815 for diagnosing SLN properties, showing no significant difference compared to diagnosis with CEUS or STQ parameters alone ([Formula: see text] 0.149, 0.516, [Formula: see text] 0.882, 0.606). CONCLUSION: Combined use of perfusion characteristics evaluated by CEUS and STQ parameters can significantly improve the diagnostic specificity of SLN in breast cancer. It is worthy of clinical promotion.
Burnout Professional Fulfilment and Sleep Quality in Indian Healthcare Workers in Times of the Covid-19 Pandemic
Authors: Somaiya Mansi , Shikhare Aishwarya , Shaikh Mohammed Ali , Subramanyam Alka A. 
Published: September 2024

Aim and Background: With more than 210 nations affected, the SARS-COV-2 became the most widespread worldwide pandemic. As of 14 April 2022, over 500 million cases were confirmed globally Given these numbers, it was hardly surprising that the Covid-19 epidemic significantly strained healthcare systems worldwide. This study aimed to evaluate the degree of Burnout, Professional fulfilment, and Sleep quality across various groups of healthcare professionals working during the Covid-19 pandemic and looked for any correlation between these three variables.
Methods: This study employed a cross-sectional observational research design and gathered data from respondents across various regions of India through an anonymous online or paper-based questionnaire tailored to the preferences of each participating Healthcare Worker (HCW). The assessment of professional fulfilment was conducted by employing the Stanford Professional Fulfillment Index and the sleep quality of healthcare workers was determined via the use of the Pittsburgh Sleep Quality Index. The variables were analyzed using statistical tools; Chi-square test, Fisher’s Exact test,Kruskal-Wallis One Way Analysis of Variance and Spearman’s rank correlation
Results: Burnout was notably higher among the HCWs with poorer Sleep quality and lower in HCWs with higher Professional Fulfilment. Correlations further revealed that Burnout scores positively correlated with Work exhaustion and Interpersonal Disengagement
Conclusion: This illustrates that HCWs with poorer sleep quality and lesser professional fulfilment experienced greater burnout at work during the COVID-19 pandemic
Clinical significance: These insights guide healthcare providers and policy markers to optimize the well being of Healthcare Workers and foster informed preparedness in case of future pandemics.
Keywords: COVID-19, PSQI, HCW, SPFI, Burnout, Professional Fulfilment, Sleep Quality.
Derajat Kepadatan Lapis Pondasi Agregat Tanpa Penutup Aspal Menggunakan Metode Sand Cone pada Proyek Rekonstruksi Jalan Kecamatan Serai Serumpun, Kabupaten Tebo di Ruas Jalan Tanjung Aur Seberang-Malako Tinggi
Authors: Yumardi Yumardi , Wijaya Sucitra , Kutni Darul , Rianto Doli Jumat , Marwadi Aji 
Published: September 2024

Road infrastructure is very important for the economic progress of Tanjung Aur Seberang village residents. Economic development in Tanjung Aur Village, Tebo Regency has significantly increased traffic levels. If this is not balanced by improving the quality of transportation facilities and infrastructure, then this could cause serious problems. Determining the value of the degree of density of the foundation layer aggregate (soil) class S in obtaining soil stability with safe conditions in accordance with the requirements of density standards is the aim of this research. The methods used are direct tests in the field and in the laboratory. Testing soil density in the field using a sand cone tool follows the provision stated in SNI 03-2828-1992, while testing soil density in the laboratory follows the provisions stated in SNI 1742-2008. Soil density testing intervals vary between 50 meters, 75 meters, 100 meters, 150 meters, 200 meters depending on location conditions. The results sand cone testing was carried out on roads from STA 2+000 to 3+800. In the first test with 9 test points, the field density was obtained below 95%, namely STA 2+100 (94,141%), STA 2 +550 (94,389%) and STA 3 +800 (94,289). Theses results indicate that the required standard degree of field density has not been achieved, so that the base layer of class S aggregate can be added and compaction can be carried out again. And from STA 0 + 005 to 4 + 200 in the second test with 26 test points. Test results using a sand cone tool show that the average water content value is 7.513% with a density reaching 98.846%. and these results were in accordance with applicable standard requirements.