bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of Navicular Injury at the NFL Combine and Their Impact on an Athlete’s Prospective NFL Career
Authors: Vopat Bryan , Beaulieu-Jones Brendin R. , Waryasz Gregory , McHale Kevin J. , Sanchez George , Logan Catherine A. , Whalen James M. , DiGiovanni Christopher W. , Provencher Matthew T. 
Published: August 2017

Background: Navicular injuries can result in persistent pain, posttraumatic osteoarthritis, and diminished performance and function. Purpose: To determine the epidemiology of navicular fracture in players participating in the National Football League (NFL) Scouting Combine and evaluate the impact of a navicular injury on the NFL draft position and NFL game play compared with matched controls. Study Design: Cohort study; Level of evidence, 3. Methods: Data were collected on players who previously sustained a navicular injury and participated in the NFL Combine between 2009 and 2015. The epidemiology of navicular injury was determined through an evaluation of the number of injuries, surgeries, and collegiate games missed as well as the position played, a physical examination, the surgical technique, and imaging findings. Players with a previous navicular injury (2009-2013) were compared with a set of matched controls. NFL performance outcomes included the draft position, career length ≥2 years, and number of games played and started within the first 2 years. Results: Between 2009 and 2015, 14 of 2285 (0.6%) players were identified as having sustained a navicular injury. A total of 11 of 14 (79%) athletes had sustained an overt navicular fracture, while 3 of 14 (21%) were diagnosed with stress reactions on magnetic resonance imaging. Eight patients who sustained a navicular fracture underwent surgery. There was evidence of ipsilateral talonavicular arthritis in 75% of players with a navicular fracture versus only 60% in the uninjured foot (odds ratio, 1.3; P = .04). Fifty-seven percent of players with navicular injury (72.7% of fractures) were undrafted versus 30.9% in the control group ( P = .001). Overall, 28.6% of players with navicular fracture played ≥2 years in the NFL compared with 69.6% in the control group ( P = .02). Conclusion: A previous navicular fracture results in a greater risk of developing posttraumatic osteoarthritis. Although only a low prevalence of navicular injury in prospective NFL players was noted, players with these injuries had a greater probability of not being drafted and not competing in at least 2 NFL seasons when compared with matched controls without an injury history to the NFL Combine.
Modified Hamilton’s Controlled Encircling Procedure for Retinal Detachment
Authors: Alves da Costa Pertuiset Paulo A. , Fanjul Dominguez Rodrigo A. , Gianello Garrido Pedro R. 
Published: August 2017

Purpose: To describe a novel, simple, and reproducible encircling scleral buckle technique based on Hamilton’s controlled encircling procedure in order to standardize buckle height achievement in cases of retinal detachment. Methods: We describe a case series in which a novel modification of Hamilton’s surgical technique was used, consisting of a typical encircling buckling procedure anchored in the center of each quadrant, with the ends of the band passed through a Watzke sleeve. Reference marks were placed to allow measurable shortening of the band when its ends were pulled to create an encircling indent. Postoperative ultrawide field retinal images were analyzed. Results: Our simple technique yielded predictable and reproducible postoperative scleral buckle heights. Shortening of the silicon band by 3, 4, 5, and 6.25 mm produced shallow indents, while additional shortening was considered excessive. Conclusion: Published studies about scleral buckle as a primary procedure or a combined technique with vitrectomy lack a uniform surgical technique. Our modification of Hamilton’s technique uses objective measurements to generate a consistent and predictable postoperative buckle height.
TP53 mutations identify younger mantle cell lymphoma patients who do not benefit from intensive chemoimmunotherapy
Authors: Eskelund Christian W. , Dahl Christina , Hansen Jakob W. , Westman Maj , Kolstad Arne , Pedersen Lone B. , Montano-Almendras Carmen P. , Husby Simon , Freiburghaus Catja , Ek Sara , Pedersen Anja , Niemann Carsten , Räty Riikka , Brown Peter , Geisler Christian H. , Andersen Mette K. , Guldberg Per , Jerkeman Mats , Grønbæk Kirsten 
Published: August 2017

Key Points
The intensified standard-of-care regimens for younger patients with MCL do not overcome the deleterious effects of TP53 mutations. MCLs with TP53 mutations should be considered for alternative frontline treatment.
Medical support during an Ironman 70.3 triathlon race
Authors: Yang Hae-Rang , Jeong Jinwoo , Kim Injoo , Kim Ji Eun 
Published: August 2017

Background: The Ironman 70.3 race is also called a half Ironman, and consists of 1.9 km of swimming, 90.1 km of cycling, and 21.1 km of running. The authors provide practical insights that may be useful for medical support in future events by summarizing the process and results of on-scene medical care. Methods: The medical post was established at the transition area between the cycling and running courses, which was close to the finish line, and staffed with the headquarters team comprised of an emergency physician, an EMT, two nurses, and an ambulance with a driver. The other five ambulances were located throughout the course. The medical staff identified participants according to their numbers when providing medical support, and described complaints, treatment provided, and disposition. When treating non-participants, gender and age were recorded instead of numbers. The treatment records were analyzed after the race. Results: The medical team treated a total of 187 participants. One suffered cramps in the calf muscles during the swimming part of the course. Nineteen were treated for injuries suffered during the cycling race. A total of 159 were treated for injuries on the running course. Five casualties, all of which occurred during the cycling race, required transport to hospital. Conclusions: Medical directors preparing medical support during a triathlon event should expect severe injuries in the cycling course. In hot climates, staff may also suffer from heat injuries as well as runners, and proper attention should be paid to these risks.
Oral rehydration of malnourished children with diarrhoea and dehydration: A systematic review
Authors: Houston Kirsty A. , Gibb Jack G. , Maitland Kathryn 
Published: August 2017

Background: Diarrhoea complicates over half of admissions to hospital with severe acute malnutrition (SAM). World Health Organization (WHO) guidelines for the management of dehydration recommend the use of oral rehydration with ReSoMal (an oral rehydration solution (ORS) for SAM), which has lower sodium (45mmols/l) and higher potassium (20mmols/l) content than standard ORS. The composition of ReSoMal was designed specifically to address theoretical risks of sodium overload and potential under-treatment of severe hypokalaemia with rehydration using standard ORS. In African children, severe hyponatraemia at admission is a major risk factor for poor outcome in children with SAM complicated by diarrhoea. We therefore reviewed the evidence for oral rehydration therapy in children with SAM. Methods: We conducted a systematic review of randomised controlled trials (RCTs) on 18th July 2017 comparing different oral rehydration solutions in severely malnourished children with diarrhoea and dehydration, using standard search terms. The author assessed papers for inclusion. The primary endpoint was frequency of hyponatraemia during rehydration. Results: Six RCTs were identified, all published in English and conducted in low resource settings in Asia. A range of ORS were evaluated in these studies, including standard ORS, hypo-osmolar ORS and ReSoMal. Hyponatraemia was observed in two trials evaluating ReSoMal, three children developed severe hyponatraemia with one experiencing convulsions. Hypo-osmolar ORS was found to have benefits in time to rehydration, reduction of stool output and duration of diarrhoea. No trials reported over-hydration or fatalities. Conclusions: Current WHO guidelines strongly recommend the use of ReSoMal based on low quality of evidence. Studies indicate a significant risk of hyponatraemia on ReSoMal in Asian children, none have been conducted in Africa, where SAM mortality remains high. Further research should be conducted in Africa to evaluate optimal ORS for children with SAM and to generate evidence based, practical guidelines.
Successful use of percussion pacing in a pre-hospital p-wave asystole and ventricular standstill
Authors: Betzer Martin , Allon Jan 
Published: August 2017

Background: The use of percussion pacing (PP) using a clenched fist as an external cardiac pacemaker is not scientifically supported. However, European Guidelines for resuscitation 2015 recommend PP as an initial intervention for haemodynamically unstable patients with bradyarrhythmias or p-wave asystole. We describe a case where paramedics witnessed a patient developing p-wave asystole with ventricular standstill, and treated the patient successfully with PP until transcutaneous pacing was established. Case presentation: An 87-year-old man with a previous history of bifascicular heart block collapsed in his private residence in Denmark. Initially conscious and clinically unstable when assessed by Emergency Medical Services (EMS), his condition quickly deteriorated and lost consciousness. PP was initiated resulting in electric capture in shape of broad QRS complexes on the ECG tracing corresponding with palpable carotid pulses and rise in consciousness. The successful intervention lasted for 20 seconds until transcutaneous pacing was commenced and further treatment was established. The patient survived to hospital admission. Conclusions: Although current research has not been able to establish a scientific base for the use of PP in extreme bradycardia and p-wave asystole, several case reports have been published. We contribute to these with our description of an 87-year-old man who benefited from this easy to use and probably life-saving intervention. To our best knowledge, this is the first case report of Danish paramedics intervening with PP.
Human Hepatocyte Metabolism of Novel Synthetic Cannabinoids MN-18 and Its 5-Fluoro Analog 5F-MN-18
Authors: Diao Xingxing , Carlier Jeremy , Zhu Mingshe , Huestis Marilyn A 
Published: August 2017

Abstract

BACKGROUND
In 2014, 2 novel synthetic cannabinoids, MN-18 and its 5-fluoro analog, 5F-MN-18, were first identified in an ongoing survey of novel psychoactive substances in Japan. In vitro pharmacological assays revealed that MN-18 and 5F-MN-18 displayed high binding affinities to human CB1 and CB2 receptors, with Ki being 1.65–3.86 nmol/L. MN-18 and 5F-MN-18 were scheduled in Japan and some other countries in 2014. Despite increasing prevalence, no human metabolism data are currently available, making it challenging for forensic laboratories to confirm intake of MN-18 or 5F-MN-18.

METHODS
We incubated 10 μmol/L of MN-18 and 5F-MN-18 in human hepatocytes for 3 h and analyzed the samples on a TripleTOF 5600+ high-resolution mass spectrometer to identify appropriate marker metabolites. Data were acquired via full scan and information-dependent acquisition-triggered product ion scans with mass defect filter.

RESULTS
In total, 13 MN-18 metabolites were detected, with the top 3 abundant metabolites being 1-pentyl-1H-indazole-3-carboxylic acid, pentyl-carbonylated MN-18, and naphthalene-hydroxylated MN-18. For 5F-MN-18, 20 metabolites were observed, with the top 3 abundant metabolites being 5′-OH-MN-18, MN-18 pentanoic acid, and 1-(5-fluoropentyl)-1H-indazole-3-carboxylic acid.

CONCLUSIONS
We have characterized MN-18 and 5F-MN-18 metabolism with human hepatocytes and high-resolution mass spectrometry, and we recommend characteristic major metabolites for clinical and forensic laboratories to identify MN-18 and 5F-MN-18 intake and link observed adverse events to these novel synthetic cannabinoids.
Head phantoms for electroencephalography and transcranial electric stimulation: a skull material study
Authors: Hunold Alexander , Strohmeier Daniel , Fiedler Patrique , Haueisen Jens 
Published: August 2017

Abstract
Physical head phantoms allow the assessment of source reconstruction procedures in electroencephalography and electrical stimulation profiles during transcranial electric stimulation. Volume conduction in the head is strongly influenced by the skull, which represents the main conductivity barrier. Realistic modeling of its characteristics is thus important for phantom development. In the present study, we proposed plastic clay as a material for modeling the skull in phantoms. We analyzed five clay types varying in granularity and fractions of fire clay, each with firing temperatures from 550°C to 950°C. We investigated the conductivity of standardized clay samples when immersed in a 0.9% sodium chloride solution with time-resolved four-point impedance measurements. To test the reusability of the clay model, these measurements were repeated after cleaning the samples by rinsing in deionized water for 5 h. We found time-dependent impedance changes for approximately 5 min after immersion in the solution. Thereafter, the conductivities stabilized between 0.0716 S/m and 0.0224 S/m depending on clay type and firing temperatures. The reproducibility of the measurement results proved the effectiveness of the rinsing procedure. Clay provides formability, is permeable to ions, can be adjusted in conductivity value and is thus suitable for the skull modeling in phantoms.
Using Bayes’ rule in diagnostic testing: a graphical explanation
Authors: Johnson Kevin M. 
Published: August 2017

Abstract
In the context of diagnostic testing, concepts such as sensitivity, specificity, predictive values, likelihood ratios and more are all interconnected, but precisely how can be confusing to the nonstatistician. This paper presents a graphical explanation. Bayes’ rule, or theorem, ties several of these concepts together and should have a role in careful diagnostic thinking. It too can be understood in terms of the “two-by-two diagram” presented here.
Peer assistance among mixed-age pairs in mixed-age EFL secondary school classrooms in Germany
Authors: Kos Tomas 
Published: August 2017

AbstractDrawing from a sociocultural framework, this paper reports a study which investigated peer assistance among 10 mixed-age pairs (n=20) in mixed-age English as a foreign language (EFL) secondary school classrooms in Germany which are simultaneously mixed-ability classrooms. Mixed-age is increasingly used (Kallery and Loupidou 2016; Kuhl et al. 2013; Thurn 2011), but is under-researched in language classrooms. Although some research has been conducted in L2 mixed-proficiency settings, there has been no study conducted on peer-interactions within mixed-age groups/pairs in L2 contexts. This study aims to lay the foundations for future research of peer interactions among M-A second language learners. Results show that mixed-age pairs assisted one another in ways similar to those found in teacher-learner interactions, while some in ways which resemble to what Donato (1988, 1994) called collective scaffolding. However, the extent that this assistance benefited learning varied across learners. The findings also suggest that rather than age, the relationship between learners seems to be one of the major factors mediating the extent and quality of assistance.
On Joking Contexts: An Example of Stand-Up Comedy
Authors: Filani Ibukun 
Published: August 2017

AbstractStudies on stand-up comedy and jokes have noted that context plays a major role in the generation and interpretation of jokes and humorous routines. However, these studies do not formalize the concept and what constitute it in joke exchanges. Focusing on Nigerian stand-up comedy, this study is aimed at conceptualizing and describing the contexts that could be found in joking exchanges. The study proposes two types: context-of-the-joke and context-in-the-joke. The context-of-the-joke is grounded in shared beliefs that exist between the participants-of-the-joke. The context-in-the-joke is characterized by features such as joke utterance, participants-in-the-joke (most especially the target) and activity-in-the-joke among others. These features make up the contextualization cues that the participants-of-the-joke (both the joke teller and recipient) use in joke generation and interpretation.
Knowledge of hepatitis B virus infection and its control practices among dental students in an Indian city
Authors: Khandelwal Vishal , khandelwal Sushma , Gupta Neetu , Nayak Ullal Anand , Kulshreshtha Namrata , Baliga Sudhindra 
Published: August 2017

AbstractBackgroundHepatitis B virus infection is a general cause of chronic hepatitis, liver cirrhosis and hepato-cellular carcinoma worldwide. It is highly contagious. It is an important reason for morbidity and mortality in the Indian population. Oral health professionals are at the highest risk. Vaccination for hepatitis B can prevent this deadly disease.MethodsThe present study was designed to evaluate the degree of awareness, knowledge of hepatitis B infection and status of hepatitis B vaccination among dental students. A cross-sectional study was conducted among 240 students of 3rd year, 4th year and interns of a professional dental course. A pre-tested questionnaire was given to the students of each year. All the data management and analysis were carried out using SPSS software version 16.ResultsEighty-six percent of the students had knowledge about hepatitis B infection. The majority of the students had correct knowledge regarding mode of transmission, however, 21% failed to recognize saliva as the mode of hepatitis B transmission. Forty-five percent of the students were vaccinated for hepatitis B.ConclusionThe present study concludes that there is reasonable awareness of hepatitis B infection hazards, its transmission and vaccination, among the dental students who will be entering into the profession. However, half of the students were not vaccinated for hepatitis B in our study group, which keeps them at risk to the disease. The Indian Health Ministry should make hepatitis B vaccination mandatory for all health care professionals. A strategy should be executed for health education and compulsory vaccination of all students joining the health care professional colleges. Antibody titers should be routinely checked among those who are vaccinated.
Characteristics, reasons, behavior and knowledge towards waterpipe smoking in Saudi Arabia
Authors: Venkatesh Elluru , Al Jemal Mohammad Yousef , Al Samani Abdullah Saleh 
Published: August 2017

AbstractBackgroundThe present scenario shows that waterpipe smoking, one of tobacco smoking methods, the practice off which dates back at least 400 year is appealing to the youth. Waterpipe tobacco smoking is frequently linked with nations of the Eastern Mediterranean Region (EMR) comprising Egypt, Kuwait, Lebanon and Syria. The present study shows the socio-demographic characteristics, behavior and knowledge of youth towards waterpipe smoking. Recognizing these features may help emphasize intervention methods.MethodsA self-administered questionnaire was used to collect the data about waterpipe smoking comprising sociodemographic, behavior, reasons and knowledge from 230 university students.Results230 questionnaires were distributed from which only 199 were included in the study as 31 were excluded because of incompleteness of the survey. The mean age for starting smoking was 19.49 ± 3.75 years with 32.5% of family members and the majority of their friends engaged with waterpipe smoking. Pleasure and happiness (76%), helps me to deal with pressure (78%) and acceptance by society (91%), were the major reasons cited for waterpipe smoking. It being less harmful and less addictive (55%) compared to cigarettes and no objection from the parents (58%) were the other cited reasons. Furthermore, less than 50% of the participants had correct knowledge of its harmful effects.ConclusionIt is clearly evident from our findings that there is a meagre amount of knowledge regarding the harmful effects of waterpipe smoking. It is essential that programs to impart knowledge regarding the harmful effects of waterpipe smoking and dependence should be of the utmost importance.
The use of siRNA as a pharmacological tool to assess a role for the transcription factor NF-IL6 in the brain under in vitro and in vivo conditions during LPS-induced inflammatory stimulation
Authors: Damm Jelena , Roth Joachim , Gerstberger Rüdiger , Rummel Christoph 
Published: August 2017

Abstract

Background:
Studies with NF-IL6-deficient mice indicate that this transcription factor plays a dual role during systemic inflammation with pro- and anti-inflammatory capacities. Here, we aimed to characterize the role of NF-IL6 specifically within the brain.

Methods:
In this study, we tested the capacity of short interfering (si) RNA to silence the inflammatory transcription factor nuclear factor-interleukin 6 (NF-IL6) in brain cells under in vitro and in vivo conditions.

Results:
In cells of a mixed neuronal and glial primary culture from the rat area postrema (AP), short interfering RNA (siRNA) directed against NF-IL6 strongly reduced basal and lipopolysaccharide (LPS)-induced nuclear immunoreactivity of this transcription factor, with the strongest effect on astrocytes. The siRNA did not exert inflammatory effects in the primary culture as confirmed by unaltered levels of IL-6 in supernatants. In vivo, intracerebroventricular (i.c.v.) injections of fluorochrome labelled siRNA caused its appearance in relevant brain structures for fever induction pathways such as the vascular organ of lamina terminalis, the subfornical organ, the median preoptic nucleus (MnPO) and the AP in several cell types, including microglial cells. However, i.c.v. injections of siRNA per se caused signs of fever, anorexia and reduced locomotor activity, i.e. sickness behavior.

Conclusions:
This approach was, thus, not suitable to characterize the role NF-IL6 in the brain in vivo, namely during experimentally induced systemic inflammation.
A Bi-objective Genetic Algorithm Optimization of Chaos-DNA Based Hybrid Approach
Authors: Suri Shelza , Vijay Ritu 
Published: August 2017

Abstract
The paper implements and optimizes the performance of a currently proposed chaos-deoxyribonucleic acid (DNA)-based hybrid approach to encrypt images using a bi-objective genetic algorithm (GA) optimization. Image encryption is a multi-objective problem. Optimizing the same using one fitness function may not be a good choice, as it can result in different outcomes concerning other fitness functions. The proposed work initially encrypts the given image using chaotic function and DNA masks. Further, GA uses two fitness functions – entropy with correlation coefficient (CC), entropy with unified average changing intensity (UACI), and entropy with number of pixel change rate (NPCR) – simultaneously to optimize the encrypted data in the second stage. The bi-objective optimization using entropy with CC shows significant performance gain over the single-objective GA optimization for image encryption.