bluuebunny/crossref_metadata_2025_split huggingface dataset:
Book Review
Authors: Pizer-Bush Sarah , Snoddy Marissa 
Published: August 2016

Abstract
Therapists Creating a Cultural Tapestry: Using the Creative Therapies across Cultures, Stephanie L. Brooke and Charles E. Myers (eds) (2015) Springfield, IL: Charles C. Thomas Publishers Ltd, 328 pp., ISBN: 9780398081287, h/bk $62.95 ISBN: 9780398081294, e-book
Investigating the glass escalator effect among registered drama therapists: A gender-based examination of professional trajectory
Authors: Frydman Jason S. , Segall Jeremy 
Published: August 2016

Abstract
This research sought to identify whether the glass escalator was occurring in the profession of drama therapy. A survey asking registered drama therapists (RDTs) to identify rates of advancement between career levels was completed by 34 per cent of those polled. Independent samples t-tests exploring gender differences in the career rate of advancement determined no glass escalator effect on attainment of supervisory and upper-level clinical positions; however, results are inconclusive for subsequent conditions. Qualitative analysis of open-ended responses produced three gender-relevant categories. Qualitative and quantitative data are discussed with regard to implications for the profession and avenues for further research.
Drama therapists’ attitudes and actions regarding LGBTQI and gender nonconforming communities
Authors: Beauregard Mark , Stone Ross , Trytan Nadya , Sajnani Nisha 
Published: August 2016

Abstract
Drawing on survey research conducted in music therapy, the purpose of this study was to identify the attitudes, strengths and limitations in the field of drama therapy with regard to working with lesbian, gay, bisexual, transgender, queer, intersex (LGBTQI) and gender nonconforming (GNC) communities and to identify implications for training, research and the practice of drama therapy. A total of 136 respondents met the inclusion criteria. Results indicate that the majority of drama therapists hold an open and affirming attitude towards gender diversity and sexual orientation. Yet, discrepancies remain concerning the training received, overall level of preparedness, and participation in supervision specific to working with LGBTQI and GNC clients. Ongoing training and supervision is needed to bridge the gap between affirming attitudes and actions.
Chics, elegantes e distintas: a moda na seção Jornal das famílias da Revista da Semana (1915-1918)
Authors: Czrnorski Sediana Rizzo , Meyrer Marlise Regina 
Published: August 2016

Partindo da concepção da moda como fenômeno social diretamente ligado as transformações sociais e culturais relativas a diferentes contextos históricos, o artigo analisa a moda veiculada na Revista da Semana, como um instrumento de distinção social e de gênero, tendo como público uma parcela da elite feminina do Rio de Janeiro no início do século XX. O foco de análise é a seção Jornal das Famílias inserida na revista, no período de 1915 a 1918. Com objetivo de identificar algumas das formas pelas quais a distinção é construída através da moda, foram elencadas cinco categorias de análise: Tecidos; Indumentária e ornamentos; Detalhes; Corpo e beleza; e Sociabilidade, educação e comportamento social.
Polymorphisms of TLR4 Asp299Gly and TNF-α -308G/A in Leptospirosis
Authors: Farhanah Nur , Gasem Muhammad Hussein , Faradz Sultana MH 
Published: August 2016

AbstractBackground : TLR4 Asp299Gly and TNF-α -308G/A polymorphisms have been shown to be associated with increased susceptibility and severity of infection. TLR4 Asp299Gly polymorphism could affect the host’s ability to respond to leptospira sp. TNF-α -308G/A polymorphism, is associated with the high producer of TNF-α.Methods : Total of 36 leptospirosis patients (IgM anti leptospira and MAT positive) and healthy individual with the equal number were included. The polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using site spesific restriction enzyme.Results : Distribution of homozygous wild-type TLR4 Asp299Gly polymorphism was higher in both of groups ( 94.5:97.2%.) and homozygous mutant allele was absent. There was not significantly difference of TLR4 Asp299Gly in leptospirosis patients and healthy group ( ρ=1.00; OR 0.5; 95%CI, 0.04-5.6) and between mild and severe leptospirosis (ρ=0.54; OR 1.54 ; 95% CI, 1.20-1.98). The presence of homozygous wild-type TNF-α -308G/A polymorphism was higher between leptospirosis patients and healthy group (100:94.5%) andhomozygous mutant allele was not found in both of the groups. No significantly different of TNF-α -308G>A polymorphism between leptospirosis patient and healthy group (ρ=0.49).Conclusions : In this study, the polymorphisms of TLR4 Asp299Gly and TNF-α -308G/A were not associated with the susceptibility and severity of leptospirosis. Keywords : Leptospirosis, TLR4 Asp299Gly polymorphism, TNF-α -308G/A polymorphism
Abnormal apoptosis causes colitis and enteritis in patients with Hoyeraal–Hreidarsson syndrome due to DKC1 mutations
Authors: Ovadia Adi , Ngan Bo-Yee 
Published: August 2016

Background: Hoyeraal–Hreidarsson syndrome (HHS), the severe clinical variant of X-linked dyskeratosis congenita, is caused by germline mutations in telomere associated genes. HHS usually manifests within the first years of life and is characterized by progressive bone marrow failure, immunodeficiency, neurological features including microcephaly and developmental delay, as well as intrauterine growth retardation. The typical mucocutaneous manifestations are nail dysplasia, lacy skin pigmentation, and oral leukoplakia. Importantly, gastrointestinal involvement is reported in most patients with HHS, and may be the presenting feature. Given the spectrum of gastrointestinal diseases with a similar presentation, recognizing the unique gastrointestinal histopathology of HHS may facilitate earlier diagnosis and treatment. Methods: This case series highlights the gastrointestinal pathology findings of 2 patients with HHS caused by DKC1 gene mutations. Results: Gastrointestinal biopsies reveal loss of mucosal glands, regenerative glandular alterations and increased colonic epithelial cell apoptosis. Immunostaining of biopsies for cleaved caspase 3, a marker of cellular apoptosis, demonstrates abnormal nonapical and random locations of enterocyte exit which was further exacerbated by enteritis. Conclusion: Gastrointestinal involvement is usually the presenting feature of patients with HHS. This case series highlights the important role on gastrointestinal histopathology in facilitating a diagnosis of HHS. Statement of novelty: Detailed gastrointestinal biopsy images associated with HHS involving DKC1 mutations.
Mitochondrial function assessed by 31P MRS and BOLD MRI in non‐obese type 2 diabetic rats
Authors: Liu Yuchi , Mei Xunbai , Li Jielei , Lai Nicola , Yu Xin 
Published: August 2016

AbstractThe study aims to characterize age‐associated changes in skeletal muscle bioenergetics by evaluating the response to ischemia‐reperfusion in the skeletal muscle of the Goto‐Kakizaki (GK) rats, a rat model of non‐obese type 2 diabetes (T2D). 31P magnetic resonance spectroscopy (MRS) and blood oxygen level‐dependent (BOLD) MRI was performed on the hindlimb of young (12 weeks) and adult (20 weeks) GK and Wistar (control) rats. 31P‐MRS and BOLD‐MRI data were acquired continuously during an ischemia and reperfusion protocol to quantify changes in phosphate metabolites and muscle oxygenation. The time constant of phosphocreatine recovery, an index of mitochondrial oxidative capacity, was not statistically different between GK rats (60.8 ± 13.9 sec in young group, 83.7 ± 13.0 sec in adult group) and their age‐matched controls (62.4 ± 11.6 sec in young group, 77.5 ± 7.1 sec in adult group). During ischemia, baseline‐normalized BOLD‐MRI signal was significantly lower in GK rats than in their age‐matched controls. These results suggest that insulin resistance leads to alterations in tissue metabolism without impaired mitochondrial oxidative capacity in GK rats.
Γ-convergence of nonconvex integrals in Cheeger--Sobolev spaces and homogenization
Authors: Anza Hafsa Omar , Mandallena Jean-Philippe 
Published: August 2016

AbstractWe study Γ-convergence of nonconvex variational integrals of the calculus of variations in the setting of Cheeger–Sobolev spaces. Applications to relaxation and homogenization are given.
Bernstein center of supercuspidal blocks
Authors: Mishra Manish 
Published: August 2016

Abstract
Let

𝐆

\mathbf{G}

be a tamely ramified connected reductive group defined
over a non-archimedean local field k. We show that the Bernstein
center of a tame supercuspidal block of

𝐆
⁢

(
k
)

\mathbf{G}(k)

is isomorphic
to the Bernstein center of a depth-zero supercuspidal block of

𝐆
0

⁢

(
k
)

\mathbf{G}^{0}(k)

for some twisted Levi subgroup of

𝐆
0

\mathbf{G}^{0}

of

𝐆

\mathbf{G}

.
Inequality and Fiscal Redistribution in Middle Income Countries: Brazil, Chile, Colombia, Indonesia, Mexico, Peru and South Africa
Authors: Lustig Nora 
Published: August 2016

AbstractThis paper examines the redistributive impact of fiscal policy for Brazil, Chile, Colombia, Indonesia, Mexico, Peru and South Africa using comparable fiscal incidence analysis with data from around 2010. The largest redistributive effect is in South Africa and the smallest in Indonesia. Success in fiscal redistribution is driven primarily by redistributive effort (share of social spending to GDP in each country) and the extent to which transfers/subsidies are targeted to the poor and direct taxes targeted to the rich. While fiscal policy always reduces inequality, this is not the case with poverty. When pensions are not considered a transfer, fiscal policy increases poverty in Brazil (over and above market income poverty) due to high consumption taxes on basic goods. Total spending on education is pro-poor except for Indonesia, where it is neutral in absolute terms. Health spending is pro-poor in Brazil, Chile and South Africa, roughly neutral in absolute terms in Mexico, and not pro-poor in Indonesia and Peru.
A Framework for Ontological Policy Reconstruction: Academic Knowledge Transfer in the Netherlands as a Case Study
Authors: Pauly Marc 
Published: August 2016

AbstractThis paper provides a framework for analyzing the ontology underlying a given public policy, i.e. the categories and concepts used by the policy. It provides a set of questions concerning the language, logic and deontology of a policy and their development over time. The framework is applied to a particular case study, the valorization policy for Dutch universities, in order to suggest the usefulness of the framework in the design and normative evaluation of public policy.
The Ontology of Interactive Kinds
Authors: Hauswald Rico 
Published: August 2016

AbstractThis paper defends the notions of an interactive kind and a looping effect as features of social and human scientific classifications and aims to give a realist interpretation of them. I argue that interactive kinds can best be modeled as a special case of changing causal property cluster kinds. In order to do so, I develop a typology of looping effects according to the sort of entities that are affected, the main types of which are individual-looping, category-looping, and kind-looping. Based on this distinction, I identify interactive kinds as those causal property cluster kinds that are subjected to kind-looping.
Language, integration, and investment: The regulation of diversity in the context of unemployment
Authors: Flubacher Mi-Cha , Coray Renata , Duchêne Alexandre 
Published: August 2016

AbstractDrawing on an ethnography in regional employment offices in a French-German canton in Switzerland, it is the aim of this article to articulate the complexities involved in the practices revolving around and geared towards the role of language competences in the process of professional reintegration, particularly so with regards to migrants who speak a different language. When comparing two cases of unemployed migrant job seekers and the variable treatment by their respective consultants, we will discuss the logics, ideologies, and discourses underlying the institutional regulation of the diverse body of unemployed migrants. We argue that in particular two discourses emerged in our fieldwork that seem to frame the variable approaches: the discourse of
Crystal structure of two-dimensional coordination polymer poly-[μ2-azido-aqua-(μ2-pyrazine-2-carboxylato-κ3
O,N:N′)nickel(II)], C5H5N5O3Ni
Authors: Youzhu Yu , Yuhua Guo , Liguo Yang , Yongsheng Niu 
Published: August 2016

Abstract
C5H5N5O3Ni, monoclinic, C2/c (no. 15), a = 8.5804(17) Å, b = 13.790(3) Å, c = 13.969(3) Å, β = 104.37(3)°, V =1601.2(6)Å3, Z = 8, R
gt(F) = 0.0203, wR
ref(F
2) = 0.0550, T = 293 K.
Crystal structure of 4-(benzofuran-2-yl)-2-(3-(4-fluorophenyl)-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl)thiazole, C28H20FN3OS
Authors: El-Hiti Gamal A. , Abdel-Wahab Bakr F. , Hegazy Amany S. , Ajarim Mansour D. , Kariuki Benson M. 
Published: August 2016

Abstract
C28H20FN3OS, triclinic, P1̅ (no. 2), a = 9.5719(5) Å, b = 10.7499(6) Å, c = 10.9238(5) Å, α = 95.470(4)°, β = 102.133(4)°, γ = 97.962(4)°, V = 1079.30(10) Å3, R
gt(F) = 0.0482, wR
ref(F
2) = 0.1143, T = 150(2) K.
Physicochemical Stability of Mozobil® (Plerixafor) Solution for Injection in Glass Vials and Plastic Syringes over a Three-Month Storage Period
Authors: Kim Sun Hee , Thiesen Judith , Krämer Irene 
Published: August 2016

Abstract: The stability of ready-to-administer parenteral preparations is an important issue of drug safety. Profound knowledge about the physicochemical stability is necessary in order to determine the “beyond-use-dates” of solutions in injection vials after first opening and ready-to-administer preparations in syringes.: The aim of this study was to determine the physicochemical stability of plerixafor solution marketed as Mozobil: The stability of Mozobil: No plerixafor degradation products were detected in the HPLC chromatograms over the period of 84 days, independent of the storage temperature. In vials and syringes plerixafor concentrations declined less than 5 % over the entire test period of 84 days. The pH values remained unchanged; the mean values varied between 6.79 and 6.60 for Mozobil: Plerixafor injection solution (Mozobil
Ausdrucksformen der Spiritualität bei Schülern und jungen Erwachsenen
Authors: Büssing Arndt , Rodrigues Recchia Daniela , Surzykiewicz Janusz , Baumann Klaus 
Published: August 2016

Zusammenfassung
Bei 2.468 Schülern (18 ± 2 Jahre) sollten Ausdrucksformen der Spiritualität (ASP) mit Hilfe des ASP-Fragebogens erhoben werden. Im Vordergrund stand die Frage, welche Themenbereiche für sie von Bedeutung sind und welche Zusammenhänge mit sozialem Verhalten und Engagement bestehen. Betrachtet man die Ausprägung der ASP-Faktoren, so zeigte der Faktor Bewusster Umgang / Mitgefühl hohe Zustimmungs-Scores, Suche nach Weisheit / Einsicht und Transzendenz-Überzeugung eher moderate Scores, während die Zustimmungs-Scores für Religiöse Überzeugungen eher gering waren. Da zu vermuten ist, dass bestimmte spirituelle Haltungen und Einstellungen auch gesellschaftlich relevante Auswirkungen haben, wurden korrelative Zusammenhänge mit ethischem Verhalten sowie Engagement für andere untersucht. Hierbei zeigte sich, dass alle ASP-Faktoren, aber insbesondere die Religiöse Orientierung, moderat mit einer nach ethischen Normen ausgerichteten Lebensweise assoziiert sind. Das ehrenamtliche Engagement für andere war moderat nur mit Religiöser Orientierung und Bewusstem Umgang / Mitgefühl, das per se keine dezidiert religiöse Konnotation hat und somit auch für a-religiöse Personen bedeutsam ist, assoziiert.
Congenital hypothyroidism with delayed TSH elevation in low-birth-weight infants: incidence, diagnosis and management
Authors: Cavarzere Paolo , Camilot Marta , Popa Florina Ion , Lauriola Silvana , Teofoli Francesca , Gaudino Rossella , Vincenzi Monica , Antoniazzi Franco 
Published: August 2016

ObjectiveTo evaluate the incidence of congenital hypothyroidism (CH) with delayed TSH elevation among low-birth-weight (LBW) newborns in North-Eastern Italy and to verify if they need a second or third screening.DesignAnalysis of clinical and biochemical data of newborns affected by CH with delayed TSH elevation identified by neonatal screening.MethodsData of all newborns with birth weight (BW) <2500 g and evidence of delayed TSH elevation at newborn screening were collected between 2011 and 2014. Confirmatory tests were based on serum TSH and FT4levels. All their clinical signs at diagnosis were reported.Results57.5% of LBW newborns with delayed TSH increase at neonatal screening presented a CH with delayed TSH elevation and began a treatment withl-thyroxine. The incidence of this condition in North-Eastern Italy is therefore 1:908. The remaining infants presented a subclinical hypothyroidism (21.25%) or a complete normal serum thyroid function (21.25%). These data could be drawn only from a retesting strategy of neonatal screening.ConclusionsOur report describes the incidence of CH with delayed TSH rise in North-Eastern Italy and differentiates this clinical condition from other thyroid dysfunctions of preterm or LBW newborns. The second-screening strategy for CH in neonates with BW < 2500 g proved useful in detecting newborns who otherwise would not be identified at the first screening.
The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae
Authors: Gartenberg Marc R , Smith Jeffrey S 
Published: August 2016

Abstract
Transcriptional silencing in Saccharomyces cerevisiae occurs at several genomic sites including the silent mating-type loci, telomeres, and the ribosomal DNA (rDNA) tandem array. Epigenetic silencing at each of these domains is characterized by the absence of nearly all histone modifications, including most prominently the lack of histone H4 lysine 16 acetylation. In all cases, silencing requires Sir2, a highly-conserved NAD+-dependent histone deacetylase. At locations other than the rDNA, silencing also requires additional Sir proteins, Sir1, Sir3, and Sir4 that together form a repressive heterochromatin-like structure termed silent chromatin. The mechanisms of silent chromatin establishment, maintenance, and inheritance have been investigated extensively over the last 25 years, and these studies have revealed numerous paradigms for transcriptional repression, chromatin organization, and epigenetic gene regulation. Studies of Sir2-dependent silencing at the rDNA have also contributed to understanding the mechanisms for maintaining the stability of repetitive DNA and regulating replicative cell aging. The goal of this comprehensive review is to distill a wide array of biochemical, molecular genetic, cell biological, and genomics studies down to the “nuts and bolts” of silent chromatin and the processes that yield transcriptional silencing.
Hubby and Lewontin on Protein Variation in Natural Populations: When Molecular Genetics Came to the Rescue of Population Genetics
Authors: Charlesworth Brian , Charlesworth Deborah , Coyne Jerry A , Langley Charles H 
Published: August 2016

AbstractThe 1966 GENETICS papers by John Hubby and Richard Lewontin were a landmark in the study of genome-wide levels of variability. They used the technique of gel electrophoresis of enzymes and proteins to study variation in natural populations of Drosophila pseudoobscura, at a set of loci that had been chosen purely for technical convenience, without prior knowledge of their levels of variability. Together with the independent study of human populations by Harry Harris, this seminal study provided the first relatively unbiased picture of the extent of genetic variability in protein sequences within populations, revealing that many genes had surprisingly high levels of diversity. These papers stimulated a large research program that found similarly high electrophoretic variability in many different species and led to statistical tools for interpreting the data in terms of population genetics processes such as genetic drift, balancing and purifying selection, and the effects of selection on linked variants. The current use of whole-genome sequences in studies of variation is the direct descendant of this pioneering work.
Programmed Cell Death DuringCaenorhabditis elegansDevelopment
Authors: Conradt Barbara , Wu Yi-Chun , Xue Ding 
Published: August 2016

AbstractProgrammed cell death is an integral component of Caenorhabditis elegans development. Genetic and reverse genetic studies in C. elegans have led to the identification of many genes and conserved cell death pathways that are important for the specification of which cells should live or die, the activation of the suicide program, and the dismantling and removal of dying cells. Molecular, cell biological, and biochemical studies have revealed the underlying mechanisms that control these three phases of programmed cell death. In particular, the interplay of transcriptional regulatory cascades and networks involving multiple transcriptional regulators is crucial in activating the expression of the key death-inducing gene egl-1 and, in some cases, the ced-3 gene in cells destined to die. A protein interaction cascade involving EGL-1, CED-9, CED-4, and CED-3 results in the activation of the key cell death protease CED-3, which is tightly controlled by multiple positive and negative regulators. The activation of the CED-3 caspase then initiates the cell disassembly process by cleaving and activating or inactivating crucial CED-3 substrates; leading to activation of multiple cell death execution events, including nuclear DNA fragmentation, mitochondrial elimination, phosphatidylserine externalization, inactivation of survival signals, and clearance of apoptotic cells. Further studies of programmed cell death in C. elegans will continue to advance our understanding of how programmed cell death is regulated, activated, and executed in general.