bluuebunny/crossref_metadata_2025_split huggingface dataset:
T‐type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1
Authors: Maiques Oscar , Barceló Carla , Panosa Anaïs , Pijuan Jordi , Orgaz Jose L. , Rodriguez‐Hernandez Irene , Matas‐Nadal Clara , Tell Gemma , Vilella Ramón , Fabra Angels , Puig Susana , Sanz‐Moreno Victoria , Matias‐Guiu Xavier , Canti Carles , Herreros Judit , Marti Rosa M. , Macià Anna 
Published: January 2018

SummaryMelanoma is a malignant tumor derived from melanocytes. Once disseminated, it is usually highly resistant to chemotherapy and is associated with poor prognosis. We have recently reported that T‐type calcium channels (TTCCs) are overexpressed in melanoma cells and play an important role in melanoma progression. Importantly, TTCC pharmacological blockers reduce proliferation and deregulate autophagy leading to apoptosis. Here, we analyze the role of autophagy during migration/invasion of melanoma cells. TTCC Cav3.1 and LC3‐II proteins are highly expressed in BRAFV600E compared with NRAS mutant melanomas, both in cell lines and biopsies. Chloroquine, pharmacological blockade, or gene silencing of TTCCs inhibit the autophagic flux and impair the migration and invasion capabilities, specifically in BRAFV600E melanoma cells. Snail1 plays an important role in motility and invasion of melanoma cells. We show that Snail1 is strongly expressed in BRAFV600E melanoma cells and patient biopsies, and its expression decreases when autophagy is blocked. These results demonstrate a role of Snail1 during BRAFV600E melanoma progression and strongly suggest that targeting macroautophagy and, particularly TTCCs, might be a good therapeutic strategy to inhibit metastasis of the most common melanoma type (BRAFV600E).
Impact of routine surveillance biopsy intensity on the diagnosis of moderate to severe cellular rejection and survival after pediatric heart transplantation
Authors: Zinn Matthew D. , Wallendorf Michael J. , Simpson Kathleen E. , Osborne Ashley D. , Kirklin James K. , Canter Charles E. 
Published: January 2018

AbstractData are lacking on RSB intensity and outcomes after pediatric heart transplantation. PHTS centers received a survey on RSB practices from 2005 to present. PHTS data were obtained for 2010‐2013 and integrated with center‐matched survey responses for analysis. Survey response rate was 82.6% (38/46). Centers were classified as low‐, moderate‐, and high‐intensity programs based on RSB frequency (0—more than 8 RSB/y). RSB intensity decreased with increasing time from HT. Age at HT impacted RSB intensity mostly in year 1, with little to no impact in later years. Most centers have not replaced RSB with non‐invasive methods, but many added ECHO and biomarker monitoring. Higher RSB intensity was not associated with decreased 4‐year mortality (P=.63) or earlier detection of moderate to severe (ISHLT grade 2R/3R) cellular rejection (RSBMSR) in the first year (P=.87). First‐year RSBMSR incidence did not differ with intensity or age at HT. Significant variability exists in RSB intensity, but with no impact on timing and incidence of RSBMSR or 4‐year mortality. Reduction in RSB frequency may be safe in certain patients after pediatric HT.
Differences in the neural correlates of frontal lobe tests
Authors: Matsuoka Teruyuki , Kato Yuka , Imai Ayu , Fujimoto Hiroshi , Shibata Keisuke , Nakamura Kaeko , Yamada Kei , Narumoto Jin 
Published: January 2018

BackgroundThe Executive Interview (EXIT25), the executive clock‐drawing task (CLOX1), and the Frontal Assessment Battery (FAB) are used to assess executive function at the bedside. These tests assess distinct psychometric properties. The aim of this study was to examine differences in the neural correlates of the EXIT25, CLOX1, and FAB based on magnetic resonance imaging.MethodsFifty‐eight subjects (30 with Alzheimer’s disease, 10 with mild cognitive impairment, and 18 healthy controls) participated in this study. Multiple regression analyses were performed to examine the brain regions correlated with the EXIT25, CLOX1, and FAB scores. Age, gender, and years of education were included as covariates. Statistical thresholds were set to uncorrected P‐values of 0.001 at the voxel level and 0.05 at the cluster level.ResultsThe EXIT25 score correlated inversely with the regional grey matter volume in the left lateral frontal lobe (Brodmann areas 6, 9, 44, and 45). The CLOX1 score correlated positively with the regional grey matter volume in the right orbitofrontal cortex (Brodmann area 11) and the left supramarginal gyrus (Brodmann area 40). The FAB score correlated positively with the regional grey matter volume in the right precentral gyrus (Brodmann area 6). The left lateral frontal lobe (Brodmann area 9) and the right lateral frontal lobe (Brodmann area 46) were identified as common brain regions that showed association with EXIT25, CLOX1, and FAB based only a voxel‐level threshold.ConclusionsThe results of this study suggest that the EXIT25, CLOX1, and FAB may be associated with the distinct neural correlates of the frontal cortex.
How Does Rumination Impact Cognition? A First Mechanistic Model
Authors: van Vugt Marieke K. , van der Velde Maarten ,   ESM‐MERGE Investigators
Published: January 2018

AbstractRumination is a process of uncontrolled, narrowly focused negative thinking that is often self‐referential, and that is a hallmark of depression. Despite its importance, little is known about its cognitive mechanisms. Rumination can be thought of as a specific, constrained form of mind‐wandering. Here, we introduce a cognitive model of rumination that we developed on the basis of our existing model of mind‐wandering. The rumination model implements the hypothesis that rumination is caused by maladaptive habits of thought. These habits of thought are modeled by adjusting the number of memory chunks and their associative structure, which changes the sequence of memories that are retrieved during mind‐wandering, such that during rumination the same set of negative memories is retrieved repeatedly. The implementation of habits of thought was guided by empirical data from an experience sampling study in healthy and depressed participants. On the basis of this empirically derived memory structure, our model naturally predicts the declines in cognitive task performance that are typically observed in depressed patients. This study demonstrates how we can use cognitive models to better understand the cognitive mechanisms underlying rumination and depression.
Accuracy of international classification of diseases, ninth revision, codes for postpartum hemorrhage among women undergoing cesarean delivery
Authors: Butwick Alexander J. , Walsh Eileen M. , Kuzniewicz Michael , Li Sherian X. , Escobar Gabriel J. 
Published: January 2018

BACKGROUNDDetermining the accuracy of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD‐9) codes for postpartum hemorrhage (PPH) is vital for reaching valid conclusions about the epidemiology of PPH. Our primary objectives were to assess the performance characteristics of ICD‐9 PPH codes against a reference standard using estimated blood loss (EBL) among a cohort undergoing Cesarean delivery.STUDY DESIGN AND METHODSWe analyzed maternal discharge and EBL data from women who underwent Cesarean delivery at Kaiser Permanente Northern California facilities between 2010 and 2013. We defined PPH as an EBL of at least 1000 mL. In a secondary analysis, ICD‐9 performance characteristics were assessed using an EBL of at least 1500 mL to classify severe PPH.RESULTSWe identified 35,614 hospitalizations for Cesarean delivery. Using EBL of at least 1000 mL as the “gold standard,” PPH codes had a sensitivity of 27.8%, specificity of 97%, positive predictive value (PPV) of 74.5%, and a negative predictive value (NPV) of 80.9%. The prevalence of a PPH code (9%) was lower than the prevalence using a blood loss of at least 1000 mL (24%). Using a reference standard of EBL of at least 1500 mL, PPH codes had a sensitivity of 61.7%, specificity of 93.8%, PPV of 34.2%, and NPV of 97.9%.CONCLUSIONPPH ICD‐9 codes have high specificity, moderately high PPVs and NPVs, and low sensitivity. An EBL of at least 1500 mL as a reference standard has higher sensitivity. Our findings suggest that, for women undergoing Cesarean delivery, quality improvement efforts are needed to enhance PPH ICD‐9 coding accuracy in administrative data sets.
The impact of migration on the cross‐border M&A: Some evidence for Japan
Authors: Etzo Ivan , Takaoka Sumiko 
Published: January 2018

AbstractFacing the rapidly ageing society and shrinking of markets at home, Japanese firms are expanding outbound mergers and acquisitions (M&A) activity at a record pace. This study examines the determinants of Japanese cross‐border M&A activity focusing on the role of migrant networks in overcoming the informational barriers to such activity. Migrants include immigrants residing in Japan as well as Japanese citizens residing abroad. Our results suggest that the presence of immigrants and of Japanese citizens residing abroad both increase the probability of acquiring assets in a potential target country. Moreover, both communities exert positive effects on the number and value of outbound M&A deals.
The haemodynamic response to incremental increases in negative intrathoracic pressure in healthy humans
Authors: Cheyne William S. , Gelinas Jinelle C. , Eves Neil D. 
Published: January 2018

New Findings
What is the central question of this study?
The haemodynamic response to incremental increases in negative intrathoracic pressure (nITP) during spontaneous breathing and the mechanisms of cardiac impairment at these levels of nITP remain unclear.

What is the main finding and its importance?
nITP of −20 cmH2O or greater reduces stroke volume in healthy, spontaneously breathing supine humans due to direct ventricular interaction and increased left ventricular afterload.

AbstractNegative intrathoracic pressure (nITP) generally augments venous return and left ventricular (LV) stroke volume (LVSV), though large increases in nITP, commonly seen in respiratory disease, attenuate LVSV. Despite this consistent finding, the degree of nITP required to reduce LVSV and the contributions of series and direct ventricular interaction (DVI) in mediating this response remain unclear. We hypothesized that nITP ≤−15 cmH2O would augment LVSV, while nITP ≥−20 cmH2O would reduce LVSV via DVI and increased afterload. Twenty‐three healthy subjects were randomly given inspiratory loads during spontaneous breathing to generate −5, −10, −15, −20 and −25 cmH2O. LV volumes, LV geometry, inferior vena cava collapsibility (cIVC) and LV end‐systolic meridional wall‐stress (LVESMWS) were assessed in the supine position using tri‐plane echocardiography. LVSV remained unchanged up to −15 cmH2O, but was significantly reduced at nITP ≥−20 cmH2O (−12 ± 8% and −15 ± 11% at −20 and −25 cmH2O, respectively, P < 0.05) due to significant reductions in LV end‐diastolic volume (LVEDV), while LV end‐systolic volume was unchanged. cIVC on inspiration was significantly increased at all levels of nITP, while LVESMWS only increased at −25 cmH2O (P < 0.05). DVI, as indicated by a significant increase in the radius of septal curvature, occurred at nITP ≥−10 cmH2O. In supine healthy humans, nITP ≤−15 cmH2O does not significantly affect LV function, despite increased DVI. In contrast, nITP ≥−20 cmH2O causes significant reductions in LVSV and LVEDV, which appear to be mediated by DVI and increased afterload at −25 cmH2O. The impact of cIVC during nITP remains unclear.
Precooling of Citrus Fruits
Authors: Sutton George E. 
Published: January 2018

To introduce the subject of precooling it would probably be well to define precooling. As used in most cases precooling means the rapid cooling during or as soon after processing as possible. This is done in order to remove not only the field heat but to reduce the fruit temperature in order to reduce respiration. In addition to previous reasons, precooling will lower the temperature of fruit loaded into cars, consequently reducing the refrigeration load on the car. The end effect of precooling is to provide the customer with better fruit and as a consequence to increase sales.
Paper published with permission.
Corrosion Resistant Materials for the Citrus Processing Industry
Authors: Tiffin Wm. T. 
Published: January 2018

One of the most perplexing problems that confronts the designer of citrus processing machinery and equipment is that of corrosion resistance. Citrus waste product, pulp, and juice have a citric acid content of around 2.7% by weight which will quickly destroy paint or lacquer finishes and will rapidly corrode carbon or low alloy steels. Only the highly alloyed chromium nickel steels, monel, inconel, pure nickel, some of the bronzes, tin and copper can withstand the corrosive attack of citrus juice and pulp.
Paper published with permission.
Production and Distribution of Chilled Citrus Salads
Authors: Hamrick David O. 
Published: January 2018

The production and distribution of chilled citrus segments and salads has developed into an important outlet for Florida citrus within the last few years. These chilled segments are highly perishable sections clipped from oranges or grapefruit, using technics similar to the ones developed in the commercial canned section operation of the Florida citrus industry. The sections are subjected to a minimum of processing and for this reason maintain a substantial amount of their natural flavor for several weeks provided adequate refrigeration is provided.
Paper published with permission.
Some Engineering Aspects of New Metal Container Materials
Authors: Pilcher R. W. , Lueck R. H. 
Published: January 2018

During recent years, a number of plans for the development and sale of rigid metal containers made of materials other than tin plate have been publicly stated. While dealing primarily with the use of aluminum alloys, these announcements (1, 2, 3, 4) reflect general interest since World War II in the development of metal cans made from tin-free materials which would replace or compete with tin plate cans. This discussion will review within the limitations of space and time the progress made in this over-all field and, in particular, indicate the major engineering and economic problems which attend this development area.
Paper published with permission.
Factors Involved in Selecting Optimum Size Industrial Valves and Pipes
Authors: Riopelle Earl F. 
Published: January 2018

The transporting of liquids and gases is a basic need of civilization. Many methods have been and are used, ranging from the Egyptian water jar to the modern pipe line. The method used in today’s economy depends on the kind and amount of fluid to be transported. Martinis are delivered in 2 ounce glasses by a waiter, whereas oil is transported by 6 to 16 inch pipe lines. For purposes of discussion in this paper we will assume that the requirements are such that the fluid must be delivered to a particular location at a uniform rate. Thus, with this assumption, the most economical method of transporting would be by pipe. If the pipe and valve circuit is to be designed for most economical installation and operation, there are several things that should be known at the outset.
Paper published with permission.
Automatic Lubrication
Authors: Brouillette Herbert J. 
Published: January 2018

Mr. Chairman, Representatives of the Citrus Industry, Members of the A.S.M.E., I am honored to be here today. Processing of pine trees may seem to be a long way from processing citrus fruits; however, if you’ll stop to think about it — all processings using machinery have kinship. My subject is “Automatic Lubrication” — if I’m successful in conveying one sound usable idea to a person in this rather large audience, I will be most happy and consider I have accomplished my mission here.
Paper published with permission.
Can Handling Principles as Applied to Today’s 6 Oz. Concentrate Can
Authors: Bair D. O. 
Published: January 2018

Engineering of can conveying systems has been far from an exact science in the past. The conveying components of yesterday’s systems were based upon the experience of individuals along with advice from the Farmer’s Almanac, old wives’ tales, practical jokes, medicine man’s chants and astrologer’s forecasts. This was, and still is, practical where cans are built from automobile body plate and where they are filled at 150 cans per minute. In those days, can conveying problems were relatively non-existent, and even as line speeds increased, can conveying methods were over-shadowed by can closing, can processing and can manufacturing problems. Even today many production supervisor’s view can handling by yesterday’s standards. However, the high speed lines, and relatively fragile cans and products of today, are demanding that each segment of the can conveying system be thoroughly engineered and controlled.
Paper published with permission.
Application of Centrifuges in the Recovery of Citrus Flavor Fractions
Authors: Thrush R. E. 
Published: January 2018

In recent years, there has been a marked increase in the use of centrifugals in the Citrus Industry. Centrifuges have been adapted to applications for pulp control in the production of fresh juice, in pulp reduction of the pulp wash and for control of the pulp level in the juice being fed to the evaporating system.
Paper published with permission.
Unitized Distribution Systems
Authors: Swanson Lawrence F. 
Published: January 2018

Good Morning, Gentlemen, it’s a pleasure being here with you. In fact, I might even say it’s truly a joy for me because I personally am attracted to your State of Florida very much. With all its industrial growth and beaches and bikinis, not to mention Don Metzger’s typically beautiful weather, who wouldn’t be attracted?
Paper published with permission.
Canned Chilled Juice
Authors: Boyd John M. , Carroll Eugene A. , Enns Wilbur G. 
Published: January 2018

The title of this talk was chosen deliberately to avoid possible confusion with the present canned single strength orange juice. However, the term “chilled juice” may disappear with the adoption of the new U. S. standards for “pasteurized orange juice”. If the processors adopt the recommendations of the Florida Canners Association Sub-Committee on juice quality standards, regular canned juice will be greatly improved. The cooling to not over 50° F. and storage at 50° F. maximum, along with an increase of the minimum brix to 11° and minimum Brix-acid ratio to 12 for Grade A, would result in substantial improvement in average quality.
Paper published with permission.
Storage and Handling of Dried Citrus Pulp
Authors: Ross I. J. , Boots W. S. 
Published: January 2018

Dried citrus pulp is an important by-product of the citrus processing industry. It is a bulky, granular, carbohydrate concentrate livestock feed produced by drying the peel, seed, and rag refuse of citrus fruit. Approximately 324,159 tons of citrus pulp were produced in 1964–65 (2). This amount will probably increase by more than 60 percent during the next 10 years, since the orange crop is expected to increase from the 1964–65 estimate of 83,000,000 boxes to 183,000,000 by 1975 with 80 percent of the oranges being processed (7). The 1975 grapefruit crop is expected to be 30,000,000 boxes with over one-half being processed. These increases in citrus production could mean that by 1975 over 650,000 tons of dried pulp would be produced in the State.
Paper published with permission.
A Non-Metallic Answer to Corrosion Problems
Authors: Wills Robert R. , Jacobs Eugene F. 
Published: January 2018

Corrosion is a most expensive by-product of industry. It is a fact that corrosive solutions and fumes deteriorate plant equipment at an annual rate in excess of 6 billion dollars. All companies are continually seeking new ways to decrease maintenance cost and down time.
Paper published with permission.
Recovered Volatiles From Citrus Juices
Authors: Wolford R. W. , Atkins C. D. , Dougherty M. H. , MacDowell L. G. 
Published: January 2018

In the early production of frozen concentrated orange juice (FCOJ) several factors contributed to a product quality that closely resembled the fresh juice fed to the evaporator. Among these were: fruit selection, a moderate juice yield, no heat treatment, low evaporator temperatures, cutback juice (8)2, and selected coldpressed orange oil (7).
Paper published with permission.
Citrus Pectin and Dried Pectin Peel
Authors: Snyder R. Paul 
Published: January 2018

This paper is intended to disclose knowledge of present day methods for the production of pectin and dried pectin peel by citrus fruit processing plants in Florida and in California. This study cannot be considered a complete presentation since information is not available from all producing plants. Some domestic and foreign operations can not disclose their methods due to management regulations concerning proprietary information. There are other plants where the writer has not been able to obtain specific information.
Paper published with permission.
Citrus Pulp Pelleting
Authors: Trapp William G. 
Published: January 2018

Pelleting of complete formula feeds in this country started in the early 1930’s. Today, it is estimated that over thirty million tons are pelleted annually. Pelleting of single ingredients, such as citrus fines, alfalfa meal, wheat by-products, and sugar beet pulp, received their impetus in the early 1950’s. Today, it appears that large quantities of citrus pulp will be pelleted for the domestic and foreign markets.
Paper published with permission.
d-Limonene Recovery in the Florida Citrus Industry
Authors: Schulz H. E. 
Published: January 2018

A summary is given of recovery techniques during the past 30 years. Current innovations are mentioned and the recent research completed and currently in progress. Estimated recovery yields are discussed and areas of oil loss mentioned. The major uses of d-Limonene are described and the new anti-pollution law is discussed. The economics of the limonene market are shown to be tied to the turpentine market. There are comments about the future of terpene resins. Several goals for the future are presented.
Paper published with permission.
The Occupational Safety and Health Act of 1970
Authors: Schoenborn Theodore F. 
Published: January 2018

It is a pleasure to be here today to speak to you about the Occupational Safety and Health Act of 1970, which is landmark legislation by any measure applied to it. The Act applies to every employer affecting commerce in the United States and its territories which was not covered by other Federal occupational safety and health laws, such as the Metal and Non-metallic Mine Act, the Federal Coal Mine Health and Safety Act and the Atomic Energy Act of 1954. By 1973 a study is to be completed containing recommendations for combining all Federal occupational safety and health programs.
Paper published with permission.
Bulk Storage of Citrus Concentrates
Authors: Riley Richard A. 
Published: January 2018

The Florida citrus processing industry continues to grow in complexity as it serves broader markets, handles an increasing volume of fruit at higher wage and product values, to ever stricter specifications. The trend is toward a blended finished product and away from packaging fruit as it reaches the plant; indeed, packaging is becoming to lose its “seasonal” characteristics so far as packaging and marketing is concerned.
Paper published with permission.