bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient with a total artificial heart maintained on outpatient dialysis while listed for combined organ transplant, a single center experience
Authors: Hanna Ramy M. , Hasnain Huma , Kamgar Mohammad , Hanna Mina , Minasian Raffi , Wilson James 
Published: August 2017

AbstractAdvanced mechanical circulatory support is increasingly being used with more sophisticated devices that can deliver pulsatile rather than continuous flow. These devices are more portable as well, allowing patients to await cardiac transplantation in an outpatient setting. It is known that patients with renal failure are at increased risk for developing worsening acute kidney injury during implantation of a ventricular assist device (VAD) or more advanced modalities like a total artificial heart (TAH). Dealing with patients who have an implanted TAH who develop renal failure has been a challenge with the majority of such patients having to await a combined cardiac and renal transplant prior to transition to outpatient care. Protocols do exist for VAD implanted patients to be transitioned to outpatient dialysis care, but there are no reported cases of TAH patients with end stage renal disease (ESRD) being successfully transitioned to outpatient dialysis care. In this report, we identify a patient with a TAH and ESRD transitioned successfully to outpatient hemodialysis and maintained for more than 2 years, though he did not survive to transplant. It is hoped that this report will raise awareness of this possibility, and assist in the development of protocols for similar patients to be successfully transitioned to outpatient dialysis care.
Global multielectrode contact mapping plus ablation with a single catheter: Preclinical and preliminary experience in humans with atrial fibrillation
Authors: Kottkamp Hans , Moser Fabian , Rieger Andreas , Schreiber Doreen , Pönisch Christian , Trofin Monica 
Published: August 2017

AbstractIntroductionOne question for the technological advancement of catheter ablation of atrial fibrillation (AF) is whether a creative new concept can combine and even improve the diagnostic mapping options of single‐tip and basket catheters with the simplicity of the use of balloon catheters for ablation. Herein, we describe the first in‐human experience with a single catheter offering such a complete solution.Methods and resultsA new catheter (Globe®) with a distal multielectrode array consisting of 16 ribs with 122 gold‐plated electrodes was used. Each electrode can ablate, pace, and can measure tissue contact, temperature, current, and intracardiac electrograms. The Globe was deployed and removed without difficulty in all 3 patients. Complete pulmonary vein isolation (PVI) was achieved in all 12 veins. In 10 veins, PVI was achieved with a single placement in front of the respective vein (“single circle isolation”). In one subject, the device was repositioned due to the esophagus location. In the other subject, a single gap was observed after circumferential ablation of the right inferior PV. After precise gap identification, the device was adjusted slightly for improved contact at that region, and reablation resulted in immediate PVI.ConclusionsPVI isolation could be performed with the new multielectrode array Globe in all 12 PVs offering the option for easy handling and fast “single‐shot” PVI. Several continuously updated mapping types from 122 electrodes even in real time during ablation demonstrate the capability to go beyond PVI for voltage mapping plus substrate modification, and for rotor mapping plus rotor ablation.
Catheter ablation of left atrial arrhythmias on uninterrupted oral anticoagulation with vitamin K antagonists: What is the relationship between international normalized ratio, activated clotting time, and procedure‐related complications?
Authors: Kottmaier Marc , Bourier Felix , Semmler Verena , Telishevska Martha , Koch‐Büttner Katharina , Lennerz Carsten , Lengauer Sarah , Kornmayer Marielouise , Rousseva Elena , Brooks Stephanie , Brkic Amir , Grebmer Christian , Kolb Christoph , Hessling Gabriele , Deisenhofer Isabel , Reents Tilko 
Published: August 2017

AbstractBackgroundAblation of atrial fibrillation (AF) on uninterrupted phenprocoumon reduces periprocedural thromboembolic and bleeding complications. Heparin is administered intraprocedurally to achieve activated clotting times (ACT) of 300–400 seconds. We investigated the effect of international normalized ratio (INR) on ACT and intraprocedural heparin requirements. Moreover, safety of a target ACT of 250–300 seconds was investigated.Methods and resultsWe studied 949 patients referred for AF or left atrial tachycardia ablation. Patients were divided into Group 1 (n = 249) with an INR <2 and Group 2 (n = 700) with an INR ≥2. Mean INR was 1.7 ± 0.13 in Group 1 and 2.3 ± 0.25 in Group 2. Baseline, mean, minimum and maximum ACT were significantly lower in Group 1 (138 ± 17 seconds vs. 145 ± 21 seconds; 281 ± 28 seconds vs. 288 ± 29 seconds; 251 ± 36 seconds vs. 258 ± 34 seconds; 307 ± 32 seconds vs. 316 ± 40 seconds; P <0.05). Intraprocedural heparin requirements adjusted to body weight were lower in Group 1 (127 ± 41 U/kg vs. 122 ± 40 U/kg). Weak correlations between INR and baseline, mean, minimum and maximum ACT as well as intraprocedural heparin requirements were observed. No differences regarding major or minor complications were found. INR and periprocedural anticoagulation parameters had no influence on major complications. No thromboembolic complications were observed in both groups with a target ACT value of 250–300 seconds.ConclusionsThere is only a weak correlation between INR, intraprocedural ACT, and intraprocedural heparin requirements. Periprocedural target ACT of 250–300 seconds seems safe and does not increase periprocedural bleeding and thromboembolic complications in patients undergoing RF ablation on uninterrupted phenprocoumon therapy.
Everolimus‐eluting bioresorbable vascular scaffold implantation to treat saphenous vein graft disease, single‐center initial experience
Authors: Picard Fabien , Marquis‐Gravel Guillaume , Avram Robert , Ly Hung Q. , Dorval Jean‐François , Doucet Serge , de Hemptinne Quentin , L'allier Philippe L. , Tanguay Jean‐François 
Published: August 2017

AimsRecent studies have shown favorable outcomes with everolimus‐eluting bioresorbable vascular scaffold (BVS) in patients with stable coronary artery disease. Data on the use of BVS in saphenous vein graft disease (SVG) is currently lacking.Methods and ResultsA total of 10 consecutive patients (13 lesions, including 6 in‐stent restenosis) who underwent BVS for SVG disease between May 2013 and June 2015 at a tertiary care institution were included. Median follow‐up period was 874 (720‐926) days. One patient had scaffold thrombosis (ScT) 15 months after implantation, which was treated medically. Another patient had target lesion revascularization (TLR) in two different lesions, where BVS was used to treat in‐stent restenosis. The composite endpoint of TLR, ScT, target vessel myocardial infarction, and cardiac death, was reached in two patientsConclusionsThis first real‐world data on the use of the ABSORB™ BVS in patients with SVG disease shows that its implantation is technically feasible. The observed rate of target lesion revascularization was similar to those observed with drug‐eluting stents in similar settings. Larger studies are required to better define the optimal use of BVS to treat SVG disease.
Effect of flour information (origin and organic) and consumer attitude to health and natural product on bread acceptability of Korean consumers
Authors: Ha Chung‐Hong , Lee Soh Min , Lee Eun‐Kyung , Kim Kwang‐Ok 
Published: August 2017

AbstractWhile bread is a staple food in western culture, it is a supplementary food in rice eating societies. The objective of this study was to investigate the effect of extrinsic flour information on bread acceptability in one of rice eating societies, Korea. Consumers evaluated six bread samples either blind or with flour information including which country it was produced and whether organic production was applied or not. Consumers' interest in health or in natural products was also measured. The results showed that information of using domestic flour had a strong positive effect on overall bread acceptability, while organic information particularly affected flavor preferences. Health or natural product interested people showed more distinct tendency of the above origin and organic effect. Texture liking remained unaffected by extrinsic information in all cases.Practical applicationsThe results implied the possibility of consumers who consider bread as supplementary food may be either lacking in knowledge about bread quality in relation to flours, resulting in biased expectation induced from extrinsic information or may not care bread quality as carefully as consumers in societies who consume bread as staple food. Consumer attitudes to health and to natural product were observed to be important considerations when developing market strategies for bread consumers in Korea.
Kindlin‐2 interacts with endothelial adherens junctions to support vascular barrier integrity
Authors: Pluskota Elzbieta , Bledzka Kamila M. , Bialkowska Katarzyna , Szpak Dorota , Soloviev Dmitry A. , Jones Sidney V. , Verbovetskiy Dmitriy , Plow Edward F. 
Published: August 2017

Key points
A reduction in Kindlin‐2 levels in endothelial cells compromises vascular barrier function.
Kindlin‐2 is a previously unrecognized component of endothelial adherens junctions.
By interacting directly and simultaneously with β‐ or γ‐catenin and cortical actin filaments, Kindlin‐2 stabilizes adherens junctions.
The Kindlin‐2 binding sites for β‐ and γ‐catenin reside within its F1 and F3 subdomains. Although Kindlin‐2 does not associate directly with tight junctions, its downregulation also destabilizes these junctions. Thus, impairment of both adherens and tight junctions may contribute to enhanced leakiness of vasculature in Kindlin‐2+/− mice.
AbstractEndothelial cells (EC) establish a physical barrier between the blood and surrounding tissue. Impairment of this barrier can occur during inflammation, ischaemia or sepsis and cause severe organ dysfunction. Kindlin‐2, which is primarily recognized as a focal adhesion protein in EC, was not anticipated to have a role in vascular barrier. We tested the role of Kindlin‐2 in regulating vascular integrity using several different approaches to decrease Kindlin‐2 levels in EC. Reduced levels of Kindlin‐2 in Kindlin‐2+/– mice aortic endothelial cells (MAECs) from these mice, and human umbilical ECs (HUVEC) treated with Kindlin‐2 siRNA showed enhanced basal and platelet‐activating factor (PAF) or lipopolysaccharide‐stimulated vascular leakage compared to wild‐type (WT) counterparts. PAF preferentially disrupted the Kindlin‐2+/− MAECs barrier to BSA and dextran and reduced transendothelial resistance compared to WT cells. Kindlin‐2 co‐localized and co‐immunoprecipitated with vascular endothelial cadherin‐based complexes, including β‐ and γ‐catenin and actin, components of adherens junctions (AJ). Direct interaction of Kindlin‐2 with β‐ and γ‐catenin and actin was demonstrated in co‐immunoprecipitation and surface plasmon resonance experiments. In thrombin‐stimulated HUVECs, Kindlin‐2 and cortical actin dissociated from stable AJs and redistributed to radial actin stress fibres of remodelling focal AJs. The β‐ and γ‐catenin binding site resides within the F1 and F3 subdomains of Kindlin‐2 but not the integrin binding site in F3. These results establish a previously unrecognized and vital role of Kindlin‐2 with respect to maintaining the vascular barrier by linking Vascuar endothelial cadherin‐based complexes to cortical actin and thereby stabilizing AJ.
Draft Genome Sequences of Three β-Lactam-Catabolizing Soil
Proteobacteria
Authors: Crofts Terence S. , Wang Bin , Spivak Aaron , Gianoulis Tara A. , Forsberg Kevin J. , Gibson Molly K. , Johnsky Lauren A. , Broomall Stacey M. , Rosenzweig C. Nicole , Skowronski Evan W. , Gibbons Henry S. , Sommer Morten O. A. , Dantas Gautam 
Published: August 2017

ABSTRACT

Most antibiotics are derived from the soil, but their catabolism there, which is necessary to close the antibiotic carbon cycle, remains uncharacterized. We report the first draft genome sequences of soil
Proteobacteria
identified for subsisting solely on β-lactams as their carbon sources. The genomes encode multiple β-lactamases, although their antibiotic catabolic pathways remain enigmatic.
Genome Sequences of Mycobacteriophages Kerberos, Pomar16, and StarStuff
Authors: Jacobs-Sera Deborah , Catinas Oana , Fernandez-Martinez Mariceli , Garcia Amelia , Garlena Rebecca A. , Guerrero Bustamante Carlos A. , Larsen Michelle H. , Medellin Rosa H. , Melendez-Ortiz Martin Y. , Melendez-Rivera Crystal M. , Mercado-Andino Alondra K. , Mercado-Delgado Abner J. , Ortiz-Ortiz Cathia P. , Quesada-Gordillo Ana M. , Ramos Jacqueline M. , Rubin Michael R. , Russell Daniel A. , Sadana Rachna A. , Saha Sanghamitra , Vazquez Edwin , Villarreal David , Hatfull Graham F. 
Published: August 2017

ABSTRACT
We describe the genome sequences of three closely related mycobacteriophages, Kerberos, Pomar16, and StarStuff, isolated at similar times but from geographically distinct regions. All three genomes are similar to those of other subcluster A2 phages, such as L5 and D29, are temperate, and have siphoviral virion morphologies.
First Insights into the Genome Sequence of Pseudomonas oleovorans DSM 1045
Authors: Poehlein Anja , Daniel Rolf , Thürmer Andrea , Bollinger Alexander , Thies Stephan , Katzke Nadine , Jaeger Karl-Erich 
Published: August 2017

ABSTRACT

The Gram-negative proteobacterium
Pseudomonas oleovorans
DSM 1045 is considered a promising source for enzymes of biotechnological interest, e.g., hydrolases and transaminases. Here, we present a draft sequence of its 4.86-Mb genome, enabling the identification of novel biocatalysts.
First Complete Genome Sequence of
Tobacco necrosis virus D
Isolated from Soybean and from North America
Authors: Díaz-Cruz Gustavo A. , Smith Charlotte M. , Wiebe Kiana F. , Cassone Bryan J. 
Published: August 2017

ABSTRACT

We present the first complete genome sequence of the tombusvirus
Tobacco necrosis virus D
(TNV-D) from North America, obtained from an infected soybean plant. Compared with the three other TNV-D genomes isolated from different geographic regions and host plants, its nucleotide identities were between 83% and 93%.
Complete Genome Sequence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Sequence Type 398 Isolated from Swine in the United States
Authors: Hau Samantha J. , Bayles Darrell O. , Alt David P. , Frana Timothy S. , Nicholson Tracy L. 
Published: August 2017

ABSTRACT

Methicillin-resistant
Staphylococcus aureus
(MRSA) colonizes and causes disease in many animal species. Livestock-associated MRSA (LA-MRSA) isolates are represented by isolates of the sequence type 398 (ST398). These isolates are considered to be livestock adapted. This report provides the complete genome sequence of one swine-associated LA-MRSA ST398 isolate from the United States.
Complete Genome Sequence of a Livestock-Associated Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Isolate from the United States
Authors: Hau Samantha J. , Bayles Darrell O. , Alt David P. , Frana Timothy S. , Nicholson Tracy L. 
Published: August 2017

ABSTRACT

Livestock-associated methicillin-resistant
Staphylococcus aureus
(LA-MRSA) may be the largest MRSA reservoir outside the hospital setting. One concern with LA-MRSA is the acquisition of novel mobile genetic elements by these isolates. Here, we report the complete genome sequence of a swine LA-MRSA sequence type 5 isolate from the United States.
Colonoscopic full-thickness resection using an over-the-scope device: a prospective multicentre study in various indications
Authors: Schmidt Arthur , Beyna Torsten , Schumacher Brigitte , Meining Alexander , Richter-Schrag Hans-Juergen , Messmann Helmut , Neuhaus Horst , Albers David , Birk Michael , Thimme Robert , Probst Andreas , Faehndrich Martin , Frieling Thomas , Goetz Martin , Riecken Bettina , Caca Karel 
Published: August 2017

ObjectiveEndoscopic full-thickness resection (EFTR) is a novel treatment of colorectal lesions not amenable to conventional endoscopic resection. The aim of this prospective multicentre study was to assess the efficacy and safety of the full-thickness resection device.Design181 patients were recruited in 9 centres with the indication of difficult adenomas (non-lifting and/or at difficult locations), early cancers and subepithelial tumours (SET). Primary endpoint was complete en bloc and R0 resection.ResultsEFTR was technically successful in 89.5%, R0 resection rate was 76.9%. In 127 patients with difficult adenomas and benign histology, R0 resection rate was 77.7%. In 14 cases, lesions harboured unsuspected cancer, another 15 lesions were primarily known as cancers. Of these 29 cases, R0 resection was achieved in 72.4%; 8 further cases had deep submucosal infiltration >1000 µm. Therefore, curative resection could only be achieved in 13/29 (44.8%). In the subgroup with SET (n=23), R0 resection rate was 87.0%. In general, R0 resection rate was higher with lesions ≤2 cm vs >2 cm (81.2% vs 58.1%, p=0.0038). Adverse event rate was 9.9% with a 2.2% rate of emergency surgery. Three-month follow-up was available from 154 cases and recurrent/residual tumour was evident in 15.3%.ConclusionEFTR has a reasonable technical efficacy especially in lesions ≤2 cm with acceptable complication rates. Curative resection rate for early cancers was too low to recommend its primary use in this indication. Further comparative studies have to show the clinical value and long-term outcome of EFTR in benign colorectal lesions.Trial registration numberNCT02362126; Results.
Self-reported vision impairment and incident prefrailty and frailty in English community-dwelling older adults: findings from a 4-year follow-up study
Authors: Liljas Ann E M , Carvalho Livia A , Papachristou Efstathios , De Oliveira Cesar , Wannamethee S Goya , Ramsay Sheena E , Walters Kate R 
Published: August 2017

BackgroundLittle is known about vision impairment and frailty in older age. We investigated the relationship of poor vision and incident prefrailty and frailty.MethodsCross-sectional and longitudinal analyses with 4-year follow-up of 2836 English community-dwellers aged ≥60 years. Vision impairment was defined as poor self-reported vision. A score of 0 out of the 5 Fried phenotype components was defined as non-frail, 1–2 prefrail and ≥3 as frail. Participants non-frail at baseline were followed-up for incident prefrailty and frailty. Participants prefrail at baseline were followed-up for incident frailty.Results49% of participants (n=1396) were non-frail, 42% (n=1178) prefrail and 9% (n=262) frail. At follow-up, there were 367 new cases of prefrailty and frailty among those non-frail at baseline, and 133 new cases of frailty among those prefrail at baseline. In cross-sectional analysis, vision impairment was associated with frailty (age-adjustedandsex-adjusted OR 2.53, 95% CI 1.95 to 3.30). The association remained after further adjustment for wealth, education, cardiovascular disease, diabetes, falls, cognition and depression. In longitudinal analysis, compared with non-frail participants with no vision impairment, non-frail participants with vision impairment had twofold increased risks of prefrailty or frailty at follow-up (OR 2.07, 95% CI 1.32 to 3.24). The association remained after further adjustment. Prefrail participants with vision impairment did not have greater risks of becoming frail at follow-up.ConclusionNon-frail older adults who experience poor vision have increased risks of becoming prefrail and frail over 4 years. This is of public health importance as both vision impairment and frailty affect a large number of older adults.
How safe and effective are existing treatments for wide-necked bifurcation aneurysms? Literature-based objective performance criteria for safety and effectiveness
Authors: Fiorella David , Arthur Adam S , Chiacchierini Richard , Emery Evelyne , Molyneux Andy , Pierot Laurent 
Published: August 2017

IntroductionWide-necked bifurcation aneurysms (WNBAs) present unique technical challenges for both endovascular and surgical treatments which aim to achieve complete occlusion of the aneurysm without compromising the patency of the incorporated regional parent vessels. We present a meta-analysis of traditional therapies for WNBAs to provide critical benchmarks for safety and effectiveness.MethodsFollowing a systematic search of the literature and the application of pre-specified appropriateness criteria, 43 (including 2794 aneurysms treated) and 65 (including 5366 patients treated) references with sufficient detail were identified to include in a meta-analysis of efficacy and safety, respectively. Effectiveness endpoints of both complete and adequate occlusion were assessed. A composite safety endpoint was based upon commonly applied metrics for major adverse events. Fleiss analyses were performed for both effectiveness and safety endpoints for the entire group, and then parsed separately by treatment modality (surgical clipping (SC) or endovascular therapy (EVT)) and location (anterior or posterior circulation).ResultsUsing the above methods, the core laboratory adjusted rate of complete occlusion was 46.3% (standard error 3.6%), 39.8% (3.7%), and 52.5% (9.6%) for all therapies, EVT, and SC, respectively. The rate of adequate occlusion was 59.4% (12.2%), 43.8% (5.3%), and 69.7% (14.3%) for all therapies, EVT, and SC, respectively. The rates of occurrence for pre-specified safety endpoints were 18.7% (2.9%), 21.1% (2.8%), and 24.3% (4.9%) for all therapies, EVT, and SC, respectively.ConclusionsConventional therapies for WNBAs are associated with relatively low rates of complete occlusion and peri-procedural complications are not uncommon. As new treatment technologies are investigated, it is important that the available data regarding predicate treatments is understood.
Pretreatment predictors of malignant evolution in patients with ischemic stroke undergoing mechanical thrombectomy
Authors: Davoli Alessandro , Motta Caterina , Koch Giacomo , Diomedi Marina , Napolitano Simone , Giordano Angela , Panella Marta , Morosetti Daniele , Fabiano Sebastiano , Floris Roberto , Gandini Roberto , Sallustio Fabrizio 
Published: August 2017

BackgroundFew data exist on malignant middle cerebral artery infarction (MMI) among patients with acute ischemic stroke (AIS) after endovascular treatment (ET). Numerous predictors of MMI evolution have been proposed, but a comprehensive research of patients undergoing ET has never been performed. Our purpose was to find a practical model to determine robust predictors of MMI in patients undergoing ET.MethodsPatients from a prospective single-center database with AIS secondary to large intracranial vessel occlusion of the anterior circulation, treated with ET, were retrospectively analyzed. We investigated demographic, clinical, and radiological data. Multivariate regression analysis was used to identify clinical and imaging predictors of MMI.Results98 patients were included in the analysis, 35 of whom developed MMI (35.7%). No differences in the rate of successful reperfusion and time from stroke onset to reperfusion were found between the MMI and non-MMI groups. The following parameters were identified as independent predictors of MMI: systolic blood pressure (SBP) on admission (p=0.008), blood glucose (BG) on admission (p=0.024), and the CTangiography (CTA) Alberta Stroke Program Early CT Score (ASPECTS) (p=0.001). A scoreof ≤5 in CTA ASPECTS was the best cut-off to predict MMI evolution (sensitivity 46%; specificity 97%; positive predictive value 78%; negative predictive value 65%).Conclusionsin our study a clinical and radiological features-based model was strongly predictive of MMI evolution in AIS. High SBP and BG on admission and, especially, a CTA ASPECTS ≤5 may help to make decisions quickly, regardless of time to treatment and successful reperfusion.