bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physicochemical and thermal characterization of seed oil from Mexican mamey sapote (Pouteria sapota)
Authors: Hernández‐Santos Betsabé , Sánchez‐Ortega Edgar , Herman‐Lara Erasmo , Rodríguez‐Miranda Jesús , Gómez‐Aldapa Carlos A. , Peryronel Fernanda , Marangoni Alejandro G. , Martínez‐Sánchez Cecilia E. 
Published: September 2017

AbstractThe aim of this research was to perform a physicochemical characterization of native mamey sapote seed oil [Pouteria sapota (Jacq.) H.E. Moore and Stearn]. Mamey sapote seed oil showed good oxidative stability as it had low peroxide, free fatty acid, and p‐anisidine values. The main fatty acids present in the oil were palmitic, stearic and oleic acid, constituting five major triacylglycerides families: PLP, POP, StOO, POSt and StOSt. Crystallization and melting points of the oil were −37.7 and 23.84 °C, respectively. The oil had higher SFC when the temperature was lower than 10 °C. X‐ray diffraction patterns showed that prolonged storage times lead to the formation of β crystals. Micrographs showed granular crystals (91–105 μm), with needle edges similar to cocoa butter. In addition, mamey sapote seed oil can be used in confectionery products or as a possible substitute for cocoa butter to improve and obtain good‐quality products.
Challenges in the study of adolescent and acculturative changes☆
Authors: van de Vijver Fons J.R. 
Published: September 2017

ABSTRACTThis article focuses on two recurrent themes in the study of acculturation in adolescence that challenge progress of the field. First, we often work with low‐dimensional, trait‐like models of acculturation that cannot deal with modern types of acculturation that are often characterized by multidimensionality and domain specificity. Second, acculturative change in adolescence is undertheorized and there is a need to integrate developmental tasks and models of acculturation. It is argued that approaches that have been adopted in the study of identity (with their models that range from generalized traits to situated approaches and their adoption of both quantitative and qualitative methods) are highly suitable for the study of acculturation. A more contextualized approach would also facilitate the study of the interaction of contextual conditions and acculturative changes in adolescence.
Effect of postconditioning and atorvastatin in preventing remote intestinal reperfusion injury
Authors: Santos Carlos Henrique Marques dos , Dourado Doroty Mesquita , Sampaio Trícia Luna , Dias Letícia do Espirito Santo , Almeida Murillo Henrique Martins de , Oliva João Victor Durães Gomes , Chaves Ian de Oliveira , Pontes Henrique Budib Dorsa 
Published: September 2017

Abstract
Objective To evaluate the capacity of ischemic postconditioning and atorvastatin in prevent or minimize reperfusion injury in small bowel of rats subjected to ischemia and reperfusion by abdominal aorta clamping.
Methods 41 Wistar norvegic rats were distributed into 5 groups: ischemia and reperfusion, ischemic postconditioning, postconditioning + statin, statin and Sham. After anesthesia, laparotomy and dissection of the infra-renal abdominal aorta were performed; except the Sham group, all others were subjected to aorta clamping for 70 min (ischemia) and withdrawal of clamp for 70 min (reperfusion). In the IPC and IPC + S groups, four cycles of postconditioning were performed between the phases of ischemia and reperfusion lasting 30 s each. In IPC + S and S groups, 3.4 mg/day of atorvastatin was given for seven days per gavage; 1 cm of the ileum were removed for histological study and the results were subjected to statistical treatment considering significant p < 0.05.
Results The average of intestinal lesion was 2 in the I/R group, 0.66 in the IPC group, 0 in the IPC + S group, 0 in the S group, and 0 in the SHAM group.
Conclusion The ischemic postconditioning and atorvastatin were capable of minimizing intestinal reperfusion injury, either alone or in combination.
Safety and Efficacy of Collagenase Clostridium histolyticum in the Treatment of Acute-Phase Peyronie’s Disease
Authors: Nguyen Hoang Minh Tue , Anaissie James , DeLay Kenneth J. , Yafi Faysal A. , Sikka Suresh C. , Hellstrom Wayne J.G. 
Published: September 2017

Abstract

Background
Peyronie’s disease (PD), defined as the abnormal formation of fibrous plaque(s) in the tunica albuginea of the penis, is a chronic condition that afflicts 3% to 13% of the US male population; there is no current research on the efficacy and safety of collagenase Clostridium histolyticum (CCH) in the treatment of acute phase PD.

Aim
To examine the efficacy and safety of CCH in the treatment of acute-phase PD.

Methods
We retrospectively reviewed the records for all patients treated with CCH for PD from April 2014 through April 2017. Patients who reported penile pain and duration of PD no longer than 12 months at presentation qualified as being in the acute phase of PD. The primary outcomes of interest were final changes in curvature after CCH treatment regardless of the number of CCH cycles received and frequency of treatment-related adverse events.

Outcomes
Parameters of efficacy and safety were compared between acute- and stable-phase PD.

Results
A total of 162 patients were included in the study, of which 36 (22%) qualified as having acute-phase PD (group 1) and the remaining 126 (78%) qualified as having stable-phase PD (group 2). Median duration of PD was 8.5 months (range = 1–12) for group 1 and 18 months (range = 1–492) for group 2. There was no significant difference in final change in curvature between the acute and stable phases of PD (16.7° vs 15.6°; P = .654). There was no statistically significant difference in frequency of treatment-related adverse events between the acute phase (4 patients, 11%) and the stable phase (12 patients, 10%; P = .778).

Clinical Implications
CCH therapy is as safe and efficacious in acute-phase PD as it is in stable-phase PD.

Strengths and Limitations
This is the first report that assesses the safety and efficacy of CCH therapy focusing on acute-phase PD. This study was composed of a large cohort of patients receiving CCH therapy in acute- and stable-phase PD. Limitations include bias associated with retrospective studies, a small sample, and a single-center setting.

Conclusions
Although CCH is not clearly indicated for treatment during the acute phase of PD, these results suggest that CCH use during this phase can be effective and safe. There was no statistically significant difference in final change in curvature or treatment-related adverse events after CCH therapy delivered between the acute and stable phases of PD.
Reliability and Validity of Subjective Measures of Aerobic Intensity in Adults With Spinal Cord Injury: A Systematic Review
Authors: van der Scheer Jan W. , Hutchinson Michael J. , Paulson Thomas , Martin Ginis Kathleen A. , Goosey‐Tolfrey Victoria L. 
Published: September 2017

AbstractObjectiveTo systematically synthesize and appraise research regarding test‐retest reliability or criterion validity of subjective measures for assessing aerobic exercise intensity in adults with spinal cord injury (SCI).Data SourcesElectronic databases (Pubmed, PsychINFO, SPORTDiscus, EMBASE, and CINAHL) were searched from inception to January 1, 2016.Study SelectionStudies involving at least 50% of participants with SCI who performed an aerobic exercise test that included measurement of subjective and objective intensity based on test‐retest reliability or criterion validity protocols.Data ExtractionCharacteristics were extracted on study design, measures, participants, protocols, and results. Each study was evaluated for risk of bias based on strength of the study design and a quality checklist score (COnsensus‐based Standards for the selection of health Measurement INstruments [COSMIN]).Data SynthesisThe 7 eligible studies (1 for reliability, 6 for validity) evaluated overall, peripheral and/or central ratings of perceived exertion (RPE) on a scale of 6‐20 (RPE 6‐20). No eligible studies were identified for other subjective intensity measures. The evidence for reliability and validity were synthesized separately for each measure and were assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Overall, very low GRADE confidence ratings were established for reliability and validity evidence generalizable to the entire population with SCI and various upper‐body and lower‐body modalities. There was low confidence for the evidence showing that overall RPE 6‐20 has acceptable validity for adults with SCI and high fitness levels performing moderate to vigorous‐intensity upper‐body aerobic exercise.ConclusionsHealth care professionals and scientists need to be aware of the very low to low confidence in the evidence, which currently prohibits a strong clinical recommendation for the use of subjective measures for assessing aerobic exercise intensity in adults with SCI. However, a tentative, conditional recommendation regarding overall RPE 6‐20 seems applicable, depending on participants' fitness level as well as the exercise intensity and modality used.Level of EvidenceNA
Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy
Authors: McLaughlin Matthew J. , He Yang , Brunstrom‐Hernandez Janice , Thio Liu Lin , Carleton Bruce C. , Ross Colin J.D. , Gaedigk Andrea , Lewandowski Andrew , Dai Hongying , Jusko William J. , Leeder J. Steven 
Published: September 2017

AbstractBackgroundPharmacogenomic variability can contribute to differences in pharmacokinetics and clinical responses. Pediatric patients with cerebral palsy with genetic variations have not been studied for these potential differences.ObjectiveTo determine the genetic sources of variation in oral baclofen clearance and clinical responses.DesignPharmacogenomic add‐on study to determine variability in oral baclofen clearance and clinical responses.SettingMulticenter study based in academic pediatric cerebral palsy clinics.ParticipantsA total of 49 patients with cerebral palsy who had participated in an oral baclofen pharmacokinetic/pharmacodynamic study.Methods or InterventionsOf 53 participants in a pharmacokinetic/pharmacodynamic trial, 49 underwent genetic analysis of 307 key genes and 4535 single‐nucleotide polymorphisms involved in drug absorption, distribution, metabolism, and excretion. Associations between genotypes and phenotypes of baclofen disposition (weight‐corrected and allometrically scaled clearance) and clinical endpoints (improvement from baseline in mean hamstring Modified Tardieu Scale scores from baseline for improvement of R1 spastic catch) were determined by univariate analysis with correction for multiple testing by false discovery rate.Main Outcome MeasurementsPrimary outcome measures were the genotypic and phenotypic variability of oral baclofen in allometrically scaled clearance and change in the Modified Tardieu Scale angle compared to baseline.ResultsAfter univariate analysis of the data, the SNP of ABCC9 (rs11046232, heterozygous AT versus the reference TT genotype) was associated with a 2‐fold increase in oral baclofen clearance (mean 0.51 ± standard deviation 0.05 L/h/kg for the AT genotype versus 0.25 ± 0.07 L/h/kg for the TT genotype, adjusted P < .001). Clinical responses were associated with decreased spasticity by Modified Tardieu Scale in allelic variants with SNPs ABCC12, SLC28A1, and PPARD.ConclusionsGenetic variation in ABCC9 affecting oral baclofen clearance highlights the need for continued studies of genetic polymorphisms to better characterize variable drug response in children with cerebral palsy. Single‐nucleotide polymorphisms in ABCC12, SLC28A1, and PPARD were associated with varied responses, which warrants further investigation to determine their effect on spasticity.Level of EvidenceII
Dual role of carcinoembryonic antigen-related cell adhesion molecule 6 expression in predicting the overall survival of gastric cancer patients
Authors: Zang Mingde , Hu Lei , Cao Shu , Fan Zhiyuan , Pang Li , Li Jianfang , Su Liping , Li Chen , Liu Wentao , Gu Qinlong , Zhu Zhenggang , Yan Min , Liu Bingya 
Published: September 2017

AbstractCarcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is a member of the glycosylphosphatidylinositol-linked immunoglobulin superfamily that is implicated in many human cancers. Here, we aimed to investigate the role of CEACAM6 expression in predicting the overall survival (OS) in gastric cancer (GC). The impact of CEACAM6 on the survival of patients with GC (n = 876) was assessed using an online Kaplan-Meier plotter. Findings were validated using the OS data of patients (n = 160) recruited from Ruijin Hospital. We found that high CEACAM6 expression was associated with a better OS in early-stage or well-differentiated GC, or who were treated without 5-fluorouracil (5-FU). Conversely, high CEACAM6 expression was associated with a poor OS in advanced-stage GC, poorly differentiated tumors, or who were treated with 5-FU. Furthermore, CEACAM6 may serve as a better marker for predicting OS in GC than CEA. In addition, CEACAM6 overexpression in GC cells increased apoptotic resistance to 5-FU. Moreover, CEACAM6 induced cluster of differentiation 4- and 8-positive lymphocytes were detected in early-stage GC. In conclusion, CEACAM6 plays a contradictory role in predicting the OS in GC. In early-stage GC, high CEACAM6 expression is associated with improved OS. However, in advanced-stage GC, high CEACAM6 expression is associated with a poor OS.
Self‐compared bit‐line pairs for eliminating effects of leakage current
Authors: Zhang Jingbo , Wang Jinkai , Peng Chunyu , Li Xuan , Lin Zhiting , Wu Xiulong 
Published: September 2017

This Letter proposes a new scheme to eliminate the bit‐line leakage current of static random access memory. The proposed scheme utilises a four‐input sense amplifier to amplify the voltages of self‐compared bit‐line pairs. The bit‐lines of the proposed structure have no series capacitances and are directly connected to the sense amplifier input. By this way, read delay and error caused by the leakage current of bit‐lines will be eliminated. Simulation results in SMIC 28 nm CMOS process design kits show that the proposed scheme has better stability and can decrease delay time by 41.1% at 0.9 V supply voltage compared with the X‐Calibration technology.
Online detection approach for direct current flux of power transformer
Authors: Cao Jianan , Cheng Shuai , Khan Rafiq 
Published: September 2017

Direct current (DC) flux in power transformer initiates its abnormal operation, and can eventually lead to the transformer damage. A new fluxgate sensor structure to detect the transformer's DC flux is presented. A magnetic shunt path is designed to extract fractional flux from the transformer's core limb. The DC flux can be obtained by measuring the demodulation outcomes of the output signal from the sensor's detecting coil, for there is a monotonic relation between them. The DC flux can be measured by the demodulation of output from the sensor's detecting coil. As verification, the experiment has been implemented with a 10 kVA power transformer. Measurement results show that when the external DC current, used to produce the DC flux in the transformer, varies from 0.2 to 2.5 A, the magnetic modulated output signal changes significantly and the RMS value is monotonously changing with the excited DC current.
Mode‐locked femtosecond 910 nm Nd:fibre laser with phase biased non‐linear loop mirror
Authors: Li Min , Yang Wan , Zhang Zhigang , Wang Aimin 
Published: September 2017

The authors demonstrate a mode‐locked Nd:fibre laser working at 910 nm incorporating a phase biased non‐linear loop mirror. The broadest spectral width of the pulse is 11.9 nm and the output power is 20 mW with 450 mW pump power. The dechirped pulse width is 206 fs. To the best of authors' knowledge, this is the first demonstration of a 900 nm femtosecond neodymium fibre laser based on a non‐linear loop mirror.
All‐resonator based LTCC diplexer using substrate‐integrated‐waveguides
Authors: Llamas‐Garro Ignacio , Mira Fermin , Zheng Peng , Liu Zhifu , Wu Lin‐Sheng , Wang Yi 
Published: September 2017

A compact diplexer is implemented in Low‐Temperature‐Cofired‐Ceramic (LTCC) technology and consists of six coupled substrate‐integrated‐waveguide (SIW) cavity resonators stacked in two layers. No transmission‐line based junction is used. The couplings between the cavities are achieved through both SIW irises and slots placed in metal layers. The diplexer has two third‐order filtering channels, centred at 2.7 and 3.3 GHz with 120 MHz bandwidths. The overall size of the diplexer is 27.74 mm (2.3λg at 3 GHz) × 10.4 mm (0.86λg at 3 GHz) × 0.84 mm, achieved by using an LTCC material of a high dielectric constant of 68. Simulations and measurements are in good agreement to demonstrate a compact diplexer based on an all‐resonator structure using high dielectric constant LTCC material.
Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions
Authors: Dagbay Kevin B. , Hardy Jeanne A. 
Published: September 2017

SignificanceCaspases are central players in programmed cell death. Among caspases, caspase-6 is unique for its association with neurological disorders, including Alzheimer’s, Huntington’s, and Parkinson’s diseases. The structural details underlying caspase-6 activation are still limited but are requisites in understanding caspase-6 function. The prodomain and linker play essential roles in caspase function and regulation; however, while the long prodomains in initiator caspases are known, the structures of the short prodomains in executioner caspases remain elusive, despite efforts using crystallography and NMR. Here, we used hydrogen/deuterium exchange MS and revealed two important findings: the prodomain and intersubunit linker are intrinsically disordered, and the presence or absence of these regions results in distinct structural dynamics as procaspase-6 progresses through its proteolytic activation.
First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor
Authors: Moody James D. , Levy Shiri , Mathieu Julie , Xing Yalan , Kim Woojin , Dong Cheng , Tempel Wolfram , Robitaille Aaron M. , Dang Luke T. , Ferreccio Amy , Detraux Damien , Sidhu Sonia , Zhu Licheng , Carter Lauren , Xu Chao , Valensisi Cristina , Wang Yuliang , Hawkins R. David , Min Jinrong , Moon Randall T. , Orkin Stuart H. , Baker David , Ruohola-Baker Hannele 
Published: September 2017

Significance
We describe an approach to blocking protein–protein interactions in living cells and use it to probe the earliest stages of epigenetic regulation in stem cell differentiation. We describe a computationally designed protein that tightly binds EED and disrupts PRC2 function in both cancer and stem cells. Expression of the binder at different stem cell stages identifies the first critical repressive H3K27me3 mark in embryonic development.
SparseIso: a novel Bayesian approach to identify alternatively spliced isoforms from RNA-seq data
Authors: Shi Xu , Wang Xiao , Wang Tian-Li , Hilakivi-Clarke Leena , Clarke Robert , Xuan Jianhua 
Published: September 2017

Abstract

Motivation
Recent advances in high-throughput RNA sequencing (RNA-seq) technologies have made it possible to reconstruct the full transcriptome of various types of cells. It is important to accurately assemble transcripts or identify isoforms for an improved understanding of molecular mechanisms in biological systems.

Results
We have developed a novel Bayesian method, SparseIso, to reliably identify spliced isoforms from RNA-seq data. A spike-and-slab prior is incorporated into the Bayesian model to enforce the sparsity for isoform identification, effectively alleviating the problem of overfitting. A Gibbs sampling procedure is further developed to simultaneously identify and quantify transcripts from RNA-seq data. With the sampling approach, SparseIso estimates the joint distribution of all candidate transcripts, resulting in a significantly improved performance in detecting lowly expressed transcripts and multiple expressed isoforms of genes. Both simulation study and real data analysis have demonstrated that the proposed SparseIso method significantly outperforms existing methods for improved transcript assembly and isoform identification.

Availability and implementation
The SparseIso package is available at http://github.com/henryxushi/SparseIso.

Supplementary information
Supplementary data are available at Bioinformatics online.
Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content
Authors: Brauner Susanna , Jiang Xintong , Thorlacius Gudny Ella , Lundberg Anna M , Östberg Therese , Yan Zhong-Qun , Kuchroo Vijay K , Hansson Göran K , Wahren-Herlenius Marie 
Published: September 2017

AbstractAimsPatients with hyperlipidemia are at risk of atherosclerosis, but not all develop cardiovascular disease, highlighting the importance of other risk factors such as inflammation. Both the innate and adaptive arms of the immune system have been suggested in the initiation and propagation of plaque formation. Tri-partite motif (TRIM) 21 is a regulator of tissue inflammation and pro-inflammatory cytokine production, and has been implicated in chronic inflammatory disease. Here, we investigate a potential role for TRIM21 in coronary artery disease.Methods and resultsTrim21-deficient or wild-type bone marrow was transplanted into Ldlr-/- mice fed a hypercholesterolemic diet. The Trim21-/-->Ldlr-/- mice developed larger atherosclerotic plaques, with significantly higher collagen content compared to mice transplanted with wild-type cells. High collagen content of the atheroma is stabilizing, and has recently been linked to IL-17. Interestingly, Trim21-/-->Ldlr-/- mice had elevated CD4 and IL-17 mRNA expression in plaques, and increased numbers of activated CD4+ T cells in the periphery. An increased differentiation of naïve T cells lacking Trim21 into Th17 cells was confirmed in vitro, with transcriptomic analysis revealing upregulation of genes of a non-pathogenic Th17 phenotype. Also, decreased expression of matrix metalloproteinases (MMPs) was noted in aortic plaques. Analysis of human carotid plaques confirmed that TRIM21 expression negatively correlates with the expression of key Th17 genes and collagen, but positively to MMPs also in patients, linking our findings to a clinical setting.ConclusionIn this study, we demonstrate that TRIM21 influences atherosclerosis via regulation of Th17 responses, with TRIM21 deficiency promoting IL-17 expression and a more fibrous, stable, phenotype of the plaques.
Nontuberculous Mycobacterial Infections After Silicone Breast Implant Reconstruction Emphasize a Diversity of Infecting Mycobacteria
Authors: Romero Fabian A , Powell Eleanor A , Babady N Esther , Kaltsas Anna , Figueroa Cesar J , Pulitzer Melissa , Mehrara Babak J , Glickman Michael S , Morjaria Sejal 
Published: September 2017

Abstract
Postsurgical skin and soft tissue infections (SSTIs) caused by nontuberculous mycobacteria (NTM) are uncommon, indolent, difficult to treat, and often mimic pyogenic bacterial infections. Here we present 3 cases of NTM infections following placement of silicone implants for reconstructive breast surgery. These cases emphasize the importance of a high index of suspicion for NTM in patients with SSI after a prosthetic reconstruction refractory to conventional antibiotic therapy and the importance of early investigation with mycobacterial-specific diagnostics.