bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence, characteristics and risk factors of birth defects in central China livebirths, 2015–2022
Authors: Luo Ping , Li Qian , Yan Bin , Xiong Yusha , Li Ting , Ding Xiao , Mei Bing 
Published: September 2024

ObjectiveThis study analyzed the prevalence, epidemiological characteristics and risk factors of birth defects among livebirths in central China, aiming to provide evidences for the prevention of birth defects and government Decision-makings.MethodsBirth data from China’s Hubei Province between 2015 and 2022 were collected, including basic information of the livebirths, the mothers and the fathers, as well as information about delivery and each prenatal examination. The livebirths prevalence of birth defects was calculated and the trends were mapped. The basic characteristics of birth defects were evaluated by the difference analysis between case and health groups. Univariate and multivariate Poisson regression was performed to examine the independent risk factors for birth defects.ResultsAmong 43,568 livebirths, 166 livebirths were born with birth defects, resulted in a total prevalence rate of 3.81 per 1,000 livebirths, showing a remarkable uptrend from 0.41per 1,000 livebirths in 2015 to 9.23 per 1,000 livebirths in 2022. The peak of the prevalence was in January and February. Congenital malformation of the musculoskeletal system was the main type of birth defect in central China livebirths, followed by cleft lip and cleft palate. Overall, newborns with birth defect had significantly earlier delivery gestational age, poorer health and higher proportion of infants with low birth weight than healthy births. The gender of livebirths, excess weight at delivery (≥80 kg) of mothers, more than 2 times of gravidity or parity of mothers, and advanced paternal age (≥40 years) were independent risk factors for birth defects (or specific birth defects).ConclusionThe livebirths prevalence of birth defects shows increasing trend in central China, which deserves the attention of the government and would-be parents. Elevated paternal age, excess maternal weight, gravidity and parity should be considered when planning their families.
The development of depression and social anxiety symptoms in adolescents and the negative impact of the COVID-19 pandemic and desire for peer contact
Authors: Pinkse-Schepers Anne L. , Buil J. Marieke , Sijtsma Hester , Hollarek Miriam , Walsh Reubs J. , van Buuren Mariët , Krabbendam Lydia , Lee Nikki C. 
Published: September 2024

IntroductionAdolescence is a dynamic developmental phase in which contact with peers is crucial for socio-emotional development and wellbeing. Depression and social anxiety show patterns of high onset during this period, and more for girls than boys. Here we examine this development among Dutch adolescents, as well as how desire for more peer contact as a result of social distancing measures during the COVID-19 pandemic contributed to this increase.MethodsWe used a longitudinal three-wave design to examine 406 typically developing Dutch adolescents across two consecutive cohorts; Cohort 1: 2016–2019 (N = 138, 53.6% girls, age at T0 M = 13.00, SD = 0.42), Cohort 2: 2017–2020 (N = 268, 63.1% girls, age at T0 M = 13.05, SD = 0.39), final wave during spring 2020 during the first COVID-19 lockdown. Self-report questionnaires were used to measure depression and social anxiety symptoms, desire for change in the amount of peer contact during lockdowns, and emotion regulation. Parallel process dual latent growth models and autoregressive cross-lagged models were used to test the hypotheses.ResultsResults showed that symptoms of both depression and social anxiety increase during adolescence. Gender analysis reveal a higher initial level and increase in depression symptoms for girls, while levels for boys decreased. Adolescents exposed to the pandemic showed a steeper increase in depression but not in social anxiety. Desire for more peer contact was related to an increase in depression and social anxiety, though only in girls. No evidence was found for moderation of emotion regulation skills concerning COVID evoked emotions on the association between desire for peer contact and anxiety and depression symptom development.DiscussionSymptoms of social anxiety increased during adolescence in boys and girls. Symptoms of depression increased for girls, but decreased for boys. The increase in depression was greater in a cohort who experienced the COVID-19 pandemic. For girls, a desire for more peer contact was associated with an increase of depression and social anxiety symptoms in times of social restrictions.
Tracking temporal variations of fatality and symptomology correlated with COVID-19 dominant variants and vaccine effectiveness in the United States
Authors: Lin Shao , Liu Han , Qi Quan , Trees Ian , Gao Donghong , Friedman Samantha , Xue Xiaobo Romeiko , Lawrence David 
Published: September 2024

IntroductionWe described how COVID-19 fatality and symptoms varied by dominant variant and vaccination in the US.MethodsUsing the Restricted Access Dataset from the US CDC (1/1/2020–10/20/2022), we conducted a cross-sectional study assessing differences in COVID-19 deaths, severity indicators (hospitalization, ICU, pneumonia, abnormal X-ray, acute respiratory distress syndrome, mechanical ventilation) and 12 mild symptoms by dominant variant/vaccination periods using logistic regression after controlling for confounders.ResultsWe found the highest fatality during the dominant periods of Wild (4.6%) and Delta (3.4%). Most severe symptoms appeared when Delta was dominant (Rate range: 2.0–9.4%). Omicron was associated with higher mild symptoms than other variants. Vaccination showed consistent protection against death and severe symptoms for most variants (Risk Ratio range: 0.41–0.93). Boosters, especially the second, provided additional protection, reducing severe symptoms by over 50%.DiscussionThis dataset may serve as a useful tool to monitor temporospatial changes of fatality and symptom for case management and surveillance.
How influencers motivate inactive adolescents to be more physically active: a mixed methods study
Authors: Aschwanden Rahel , Messner Claude 
Published: September 2024

IntroductionRegular physical activity offers numerous health benefits, particularly for adolescents. However, only 14% of school-aged children in Switzerland achieve the World Health Organization's recommendation of 60 min of moderate to vigorous physical activity per day. Changing health behaviors is a complex process in which understanding behavioral and communication patterns is crucial. Because adolescents spend substantial time on social media channels and obtain information from them, these are potential channels for accessing health-related content. This study explores the questions of which influencers and what content motivate adolescents to be more physically active and whether influencers can impact enjoyment and the intention to engage in physical activity.MethodsThe study employed a convergent mixed methods approach, combining self-assessment questionnaires and semi-structured interviews. Ninety-three adolescents aged 14–20 years who exercised &lt; 1 h per day participated. They followed one of the six participating influencers on Instagram. Over 6 weeks, the questionnaires collected quantitative data, measuring enjoyment, stages of change, and physical activity levels. Furthermore, semi-structured interviews were conducted with 23 adolescents and six influencers to gain in-depth insights.ResultsThe quantitative findings indicate that adolescent followers enjoyed physical activity more after the social media intervention and at follow-up than at the beginning of the study. The followers' stages of change progressed over time. Compared with those following more athletic influencers, followers of nonathletic influencers (that is, a singer, a journalist, and an eFootballer) showed increased physical activity over time. Qualitative analysis highlighted Instagram factors influencing physical activity, including resonance with influencers' lifestyles and preference for simple, relatable activities. Authentic content was positively associated with increased exercise, particularly among already motivated followers.DiscussionUnexpectedly, nonathletic influencers, such as a singer, a journalist, and an eFootballer, motivated adolescents best despite their nontraditional focus on physical activity. Their success stems from relatable lifestyles and simple activities that are easily incorporated into their daily routines. Conversely, athletic influencers demonstrated challenging exercises that were fascinating but difficult to adopt. This finding suggests the potential for utilizing nonathletic influencers in future campaigns targeting inactive adolescents.
The applied study to improve the treatment of knee sports injuries in ultimate frisbee players based on personalized exercise prescription: a randomized controlled trial
Authors: Chen Shangmin , Du Lin , Gao Yongshan , Li Haorui , Zheng Yanxun , Xie Lei , Zhong Zhigang 
Published: September 2024

ObjectiveUltimate frisbee can lead to severe sports injuries, especially joint injuries in the lower limbs, such as knee meniscus injuries. This study examines the impact of personalized exercise therapy on knee meniscus injuries in ultimate frisbee players in the Lingnan region of China.MethodsSeventy-six patients with confirmed meniscal injuries participated in the study, divided into an intervention group (n = 38) and a control group (n = 38). The control group received standard treatment, including drug therapy and physical therapy. The intervention group received standard treatment plus a personalized exercise regimen based on FITT-VP (frequency, intensity, time, type, volume, and progression) principles, incorporating strength training, aerobic exercise, flexibility training, neuromuscular training, and aquatic exercise. This program was monitored and adjusted over a six-month period through both online and offline methods. The primary outcomes were joint range of motion (ROM), thigh circumference atrophy index (TCAI), Lysholm Rating Scale (LRS) scores, and visual analog scores (VAS). The secondary outcome was the International Knee Documentation Committee (IKDC) score. Data were collected before the intervention, and at 1 month and 6 months after the intervention. Statistical analysis was conducted using SPSS 24.0 and GraphPad 10.0, with a significance level set at α = 0.05.ResultsAfter 1 month, the intervention group showed significantly better results in ROM (116.67 ± 9.063), LRS score (86.316 ± 3.750), and IKDC score (80.473 ± 5.421) compared to the control group (111.784 ± 4.778, 82.579 ± 3.818, and 77.684 ± 4.430, respectively) (p &lt; 0.05). The TCAI (3.219 ± 1.889) and VAS score (1.921 ± 0.673) in the intervention group were significantly lower than those in the control group (5.228 ± 2.131 and 2.710 ± 1.112, respectively) (p &lt; 0.01). After 6 months, the differences in LRS and VAS scores between the groups were not significant. However, the intervention group continued to show significant improvements in ROM (134.934 ± 3.011), TCAI (1.107 ± 1.158), and IKDC score (93.315 ± 1.847) compared to the control group (125.395 ± 18.554, 4.574 ± 1.109, and 87.789 ± 4.437, respectively) (p &lt; 0.05).ConclusionPersonalized exercise prescriptions offer significant therapeutic and rehabilitative benefits for ultimate frisbee players with knee meniscus injuries. This approach helps to reduce symptoms, alleviate pain, and improve joint function, muscle strength, and athletic performance after sports-related injuries.
Hypertension risk pathways in urban built environment: the case of Yuhui District, Bengbu City, China
Authors: Gu Kangkang , Jing Yao , Tang Jingjing , Jia Xianjie , Zhang Xinmu , Wang Beichen 
Published: September 2024

IntroductionThe rapid development of urbanization has brought about changes in residents’ living environment and behavior, leading to health challenges such as hypertension. An improvement in the built-up environment in the community could contribute to the construction of a healthy city, promote the active life of the residents, and prevent and relieve hypertension. However, there is little research on the relationship between the built environment of the community and hypertension. This cross-sectional study aims to evaluate the relationship between communities’ built environment, health behavior, and hypertension grade of residents in Yuhui District of Bengbu City.MethodsThis study is based on data from the 2022 Health Survey of Residents in 21 communities. To investigate the impact of the community’s built environment on residents’ hypertension and the underlying mechanisms, regression and structural equation modeling were employed.Results and discussionThe results show that the built environment of urban communities has a significant impact on the residents’ hypertension. The presence of high densities of supermarkets, convenience stores, parks and plazas, but low densities of clinics and hospitals, has been identified as a significant risk factor for the development of high blood pressure among the residents. Nevertheless, the adoption of healthy behaviors, including regular walking, physical activity, and a diet rich in fruit and vegetables, can play an important role in reducing the risk of hypertension. The findings of this study show that enhancements to the built environment in urban neighborhoods could contribute to a reduction in the prevalence of hypertension among residents. Furthermore, the implementation of efficacious health interventions in urban settings would facilitate the alteration of residents’ health behaviors and enhance their overall health status.
Resistivity effect in the vicinity of a coronal magnetic null point
Authors: Sabri S. , Poedts S. 
Published: September 2024

Introduction: We aim to examine how magnetic resistivity impacts the movement of magnetoacoustic waves near a magnetic null-point in the solar corona.Method: The resistive, nonlinear MHD simulations are solved by the PLUTO code in 2.5D for different amount of the resistivity.Results and Discussion: Propagation of magnetoacoustic waves in the vicinity of a magnetic null point has the potential to create current sheets with high current density excitation and plasmoid generation. During the entire duration of the simulation, it is discovered that plasma density became significant due to the plasmoid and also current density is high for high resistivity. It is depicted that high resistivity also leads to bigger plasmoids or magnetic islands in comparison to small resistivity.
A review of the intersection between climate change, agriculture, health, and nutrition in Africa: costs and programmatic options
Authors: Mehra Divya , Rael Trula , Bloem Martin W. 
Published: September 2024

BackgroundClimate change adversely affects Africa’s agriculture which would worsen the widespread food insecurity and nutritional deficiencies. Vulnerable populations, especially female farmers, women, and children are disproportionately affected.MethodsThe paper synthesizes available peer-reviewed and grey literature on the intersections of climate change, food insecurity, agriculture, gender disparities, health, child nutrition, and micronutrient deficiencies in Africa. It explores the economic ramifications of these factors, particularly their impact on public health and economic stability. The work aggregates insights into the current and future challenges of agricultural sustainability and the expected human capital development and economic costs of climate variations.ResultsThe prevalence of hunger and undernourishment in Africa is notably higher compared to other regions. Climate change directly threatens agriculture, with anticipated reductions in crop and livestock yields, compounded by the negative impact of greenhouse emissions on the nutritional quality of staple foods. Female farmers contribute notably to agriculture, but their labor share is less dominant than previously assumed. Exposure to high temperatures, especially for outdoor workers and pregnant women, presents significant health risks, further impacting agricultural and economic output. These interdependencies are presented in a framework along with suggested interventions that could be contextualized to address the climate drivers and interconnectivity across agriculture, health, and livelihoods.ConclusionThe interdependence between food, agriculture, health, nutrition, and human productivity, all of which are exacerbated by the impacts of climate change in Africa, form a complex challenge with profound health and economic implications. A multifaceted strategy is needed, encompassing climate-resilient farming practices, gender-sensitive interventions, health-focused measures like micronutrient supplementation, and comprehensive economic policies.
How does the method of farmland transfer affect the “non-grain” of farmland in China?
Authors: Wang Hanrui , Zhao Qingjun 
Published: September 2024

IntroductionThe phenomenon of “non-grain” of farmland poses a major threat to food security. Currently, there is still debate about the relationship between farmland transfer and the “non-grain” of farmland. Currently, there is no consensus on the relationship between farmland transfer and the non-grain use of farmland. This article focuses on the evolution of farmland transfer methods, examines the impact of farmland transfer methods on the non-grain use of farmland, and highlights the importance of effectively promoting farmland transfer, curbing the non-grain use of farmland, and ensuring food security.MethodsBased on the China Rural Revitalization Survey (CRRS) data, this paper uses probit and ivprobit models to estimate the causal relationship between farmland transfer methods and the “non-grain” of farmland. Grouped regressions are conducted from three dimensions of geographical environment, village governance, and economic development to test the heterogeneity of the impact of farmland transfer methods. Finally, the pathways of action are analyzed from the perspectives of farmers’ identity transformation and contract signing.ResultsThe organized transfer can significantly reduce the degree of “non-grain” of farmland, and its effect is stronger when the village party secretary has a higher level of education and also serves as the village head. This effect is mainly manifested through increasing the probability of farmers becoming new agricultural operators, joining cooperatives, signing formal contracts, and determining the lease term.DiscussionThe policy implications of this study emphasize that to curb the “non-grain” of farmland and ensure food security, it is important not only to increase the rate of farmland transfer but also to promote the organization of farmland transfer transactions. This includes facilitating the transfer of farmland from inefficient smallholders and cultivating new agricultural operators. Simultaneously, leveraging the supervisory and management role of village collectives can encourage farmers to sign more formal written contracts, clarify the purpose of farmland transfer, and supervise and manage the use of farmland during the subsequent contract execution stage. A limitation of this study is that it relies on cross-sectional data and does not observe the time variation of farmland transfer methods for the same farmers or their long-term impact on the “non-grain” of farmland.
Genomic signatures of positive selection in Awarik dromedary camels from southwestern of Saudi Arabia
Authors: Almathen Faisal 
Published: September 2024

IntroductionThe Awarik camel population in southwestern Saudi Arabia exhibits unique genetic and phenotypic traits compared to other domestic camel populations. This study aims to explore the genomic signatures of positive selection in Awarik camels to understand their evolutionary history and identify genetic adaptations potentially shared with East African camel populations.MethodsWhole genome sequencing data from nine Awarik camels were analyzed using two robust intra-population haplotype-based statistical methods: integrated haplotype score (iHS) and number of segregating sites by length (nSL). These analyses were conducted to identify candidate regions under positive selection within the Awarik camel genome.Results and discussionThese analyses identified 66 and 53 candidate selection regions, encompassing 185 and 123 genes, respectively. The iHS analysis revealed significant selection signals on chromosomes 15 and 16, including a robust overlap on chromosome 15 (10 regions) involving the TRNAI-AAU gene, suggesting its critical role in adaptive processes. Additionally, chromosome 3 exhibited the highest number of candidate regions totaling 10. The nSL analysis highlighted statistically significant regions on chromosomes 2 and 7, as well as a high concentration of candidate regions on chromosome 14, totaling five regions. Notably, large candidate regions were also identified on chromosome 11 (200 kb: 51.750–51.950 kb) and chromosome 9 (325 kb: 45.825–46.150 kb). Functional annotation of these genes revealed involvement in diverse biological processes including olfactory activity, immune regulation, metabolism, insulin secretion, reproductive performance, kidney function, and cellular signaling, with specific genes like BAG5, septin 7, SLC13A1, PCED1B, BMPR1B, ZAR1, JAKMIP2, and NOTCH2 highlighted. These findings contribute to our understanding of the adaptive mechanisms of Awarik camels and have important implications for breeding and conservation strategies. Further research on these genetic adaptations, particularly those affecting immune response, is crucial to mitigate the impacts of climate change on camel populations.
Comparative Evaluation of the Antibiotic Resistance Profile of Staphylococcus aureus Isolated From Breeders and Livestock
Authors: Ifediora A. C. , Enya E. , Mbajiuka C. S. 
Published: September 2024

ObjectivesAnimals are a potential source of Methicillin Resistant Staphylococcus aureus. This study evaluated the antibiotics susceptibility pattern of S. aureus isolates from breeders and livestock.MethodsS. aureus strains were isolated from 180 livestock and 48 livestock farmers and identified using standard methods. Antibiotic susceptibility profiles and MRSA status were determined via disk diffusion susceptibility method.ResultsAmong farm workers, 37.5% were colonized by S. aureus, with pig farm workers exhibiting the highest prevalence (56.2%), cattle herders (37.5%), and goat farm workers (18.7%). MRSA carriage among livestock isolates was 41.3%, while, six isolates from the poultry farm worker were MRSA, representing a carriage of 33.3%. Drug susceptibility profiles revealed differential patterns between isolates from breeders and animals. Gentamicin and levofloxacin demonstrated higher efficacy against farm worker isolates compared to animal isolates. Resistance to cefuroxime was higher among animal isolates (84.1%) as against the 66.7% for the breeders.ConclusionThe identification of multidrug-resistant S. aureus strains underscores the risk posed to humans in contact with animals. These findings stress the importance of monitoring and managing MRSA transmission between animals and humans.