bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parathyroid hormone-(1–34) ameliorated knee osteoarthritis in rats via autophagy
Authors: Chen Chung-Hwan , Ho Mei-Ling , Chang Ling-Hua , Kang Lin , Lin Yi-Shan , Lin Sung-Yen , Wu Shun-Cheng , Chang Je-Ken 
Published: January 2018

Anterior cruciate ligament (ACL) tear can lead to osteoarthritis (OA). However, parathyroid hormone (PTH)-(1–34) was found to alleviate OA progression in a papain-induced OA model. Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with chondrocyte death and OA. Thus we examined the roles of autophagy in PTH treatment in OA after ACL transection (ACLT). Thirty-six rats were randomized into three groups: control group, ACLT-induced OA (OA) group, and OA with intra-articular PTH-(1–34) treatment (OA+PTH) group. Weight-bearing and treadmill tests were evaluated. Cartilage matrix was determined by a histological evaluation of glycosaminoglycan (GAG), Osteoarthritis Research Society International (OARSI) score, chondrocyte apoptosis, and immunohistochemistry. Rats in the OA group had significantly decreased weight bearing and running endurance. The histological results indicated that GAG, collagen type II, and chondrocyte autophagy had decreased but that the OARSI score, terminal differentiation markers (collagen type X and Indian hedgehog), and chondrocyte apoptosis had increased in the OA group. Additionally, PTH-(1–34) treatment significantly improved weight bearing and treadmill endurance, preserved GAG and collagen type II, and reduced the OARSI score and terminal differentiation markers. Finally, PTH-(1–34) ameliorated chondrocyte apoptosis by regulating the expression of autophagy-related proteins, through reducing mechanistic target of rapamycin (mTOR) and p62 and enhancing microtubule-associated protein-1 light chain 3 (LC3) and beclin-1. Reconstructive surgery after ACL rupture cannot prevent OA occurrence. Intra-articular PTH-(1–34) treatment can alleviate OA progression after ACLT and histological molecular changes. Possible mechanisms are reducing chondrocyte terminal differentiation and apoptosis, with increasing autophagy. NEW & NOTEWORTHY Anterior cruciate ligament (ACL) tear can lead to osteoarthritis (OA). Intra-articular parathyroid hormone (PTH)-(1–34) significantly improved weight bearing and treadmill endurance, preserved glycosaminoglycan and collagen type II, and reduced Osteoarthritis Research Society International (OARSI) score and terminal differentiation. Finally, PTH-(1–34) ameliorated chondrocyte apoptosis by regulating the expression of autophagy-related proteins, through reducing mechanistic target of rapamycin (mTOR) and p62 and enhancing microtubule-associated protein-1 light chain 3 (LC3) and beclin-1. PTH-(1–34) can alleviate OA progression after ACL transection. Possible mechanisms are reducing chondrocyte terminal differentiation and apoptosis, with increasing autophagy.
Beetroot juice ingestion during prolonged moderate-intensity exercise attenuates progressive rise in O2 uptake
Authors: Tan Rachel , Wylie Lee J. , Thompson Christopher , Blackwell Jamie R. , Bailey Stephen J. , Vanhatalo Anni , Jones Andrew M. 
Published: January 2018

Nitrate-rich beetroot juice (BR) supplementation has been shown to increase biomarkers of nitric oxide availability with implications for the physiological responses to exercise. We hypothesized that BR supplementation before and during prolonged moderate-intensity exercise would maintain an elevated plasma nitrite concentration ([[Formula: see text]]), attenuate the expected progressive increase in V̇o2 over time, and improve performance in a subsequent time trial (TT). In a double-blind, randomized, crossover design, 12 men completed 2 h of moderate-intensity cycle exercise followed by a 100-kJ TT in three conditions: 1) BR before and 1 h into exercise (BR + BR); 2) BR before and placebo (PL) 1 h into exercise (BR + PL); and 3) PL before and 1 h into exercise (PL + PL). During the 2-h moderate-intensity exercise bout, plasma [[Formula: see text]] declined by ~17% in BR + PL but increased by ~8% in BR + BR such that, at 2 h, plasma [[Formula: see text]] was greater in BR + BR than both BR + PL and PL + PL ( P < 0.05). V̇o2 was not different among conditions over the first 90 min of exercise but was lower at 120 min in BR + BR (1.73 ± 0.24 l/min) compared with BR + PL (1.80 ± 0.21 l/min; P = 0.08) and PL + PL (1.83 ± 0.27 l/min; P < 0.01). The decline in muscle glycogen concentration over the 2-h exercise bout was attenuated in BR + BR (~28% decline) compared with BR + PL (~44% decline) and PL + PL (~44% decline; n = 9, P < 0.05). TT performance was not different among conditions ( P > 0.05). BR supplementation before and during prolonged moderate-intensity exercise attenuated the progressive rise in V̇o2 over time and appeared to reduce muscle glycogen depletion but did not enhance subsequent TT performance. NEW & NOTEWORTHY We show for the first time that ingestion of nitrate during exercise preserves elevated plasma [nitrite] and negates the progressive rise in O2 uptake during prolonged moderate-intensity exercise.
Audio-Based Melody Categorization: Exploring Signal Representations and Evaluation Strategies
Authors: Kroher Nadine , Díaz-Báñez José-Miguel 
Published: January 2018

AbstractMelody categorization refers to the task of grouping a set of melodies into categories of similar items that originate from the same melodic contour. From a computational perspective, automatic melody categorization is of crucial importance for the automatic organization of databases, as well as for large-scale musicological studies—in particular, in the context of folk music and non-Western music traditions. We investigate methods starting from the raw audio file. For each recording contained in a collection, we extract a pitch sequence representing the main melodic line. We then estimate pairwise similarities and evaluate the discriminative power of the resulting similarity matrix with respect to ground-truth annotations. We propose novel evaluation methodologies, compare melody representations, and explore the potential of our approach in the context of two applications: interstyle and intrastyle categorization of flamenco music and tune-family recognition of folk-song recordings.
Revisiting the ENSO–SSW Relationship
Authors: Song Kanghyun , Son Seok-Woo 
Published: January 2018

AbstractStratospheric sudden warming (SSW) events exhibit pronounced interannual variability. Based on zonal wind reversals at 60°N and 10 hPa, it has been suggested that SSW events occur more preferentially during El Niño–Southern Oscillation (ENSO) winters (both El Niño and La Niña winters) than during ENSO-neutral winters. This relationship is reevaluated here by considering seven different SSW definitions. For all definitions, SSW events are detected more frequently during El Niño winters than during ENSO-neutral winters, in agreement with a strengthened planetary-scale wave activity. However, such a systematic relationship is not found during La Niña winters. While three SSW definitions, including the wind-reversal definition, show a higher SSW frequency during La Niña winters than during ENSO-neutral winters, other definitions show no difference or even lower SSW frequency during La Niña winters. This result, which is qualitatively insensitive to the choice of reanalysis datasets, ENSO indices, and SST datasets, indicates that the reported ENSO–SSW relationship is dependent on the details of the SSW definition. This result is interpreted in terms of different background wind, latitudinal extent of wind reversal, and planetary-scale wave activity during El Niño and La Niña winter SSW events.
Remeron Tablet Strengths Easy to Confuse Safety Alert: Versed Syrup Reducing Errors with IV Insulin
Authors: Cohen Michael R. 
Published: January 2018

These medication errors have occurred in health care facilities at least once. They will happen again–perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them in your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the USP Medication Errors Reporting Program, which is presented in cooperation with the Institute of Safe Medication Practices. If you have encountered medication errors and would like to report them, you may call USP tool-free, 24 hours a day, at 1-800-233-7767 (1-800-23-ERROR). Any reports published by ISMP will be anonymous. Comments are also invited; the writer's names will be published if desired. ISMP may be contacted at the address shown below.
Avandia Confused with Coumadin Safe Management of Drug Samples Long-Acting Parenteral Penicillins are Not for IV Injection
Authors: Cohen Michael R. 
Published: January 2018

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them in your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the USP Medication Errors Reporting Program, which is presented in cooperation with the Institute of Safe Medication Practices. If you have encountered medication errors and would like to report them, you may call USP toll-free, 24 hours a day, at 1-800-233-7767 (1-800-23-ERROR). Any reports published by ISMP will be anonymous. Comments are also invited; the writer's names will be published if desired. ISMP may be contacted at the address shown below.
Qualitative synthesis: A guide to conducting a meta-ethnography
Authors: Cahill Mairead , Robinson Katie , Pettigrew Judith , Galvin Rose , Stanley Mandy 
Published: January 2018

Introduction Qualitative meta-synthesis draws together data from multiple studies and can enrich understandings of client experiences and inform health policy. Meta-ethnography is the most commonly utilised qualitative synthesis approach in healthcare; however, there is variation in the conduct and quality of many published meta-ethnographies. This paper aims to guide occupational therapists on the process of completing a meta-ethnography. Method A systematic search of articles published from 1986–2016 was conducted. Studies which described an evaluation or critique of meta-ethnography as a research method, and consequently provided reflections or guidance on the method, were included. Two authors independently screened papers and nine relevant papers and one key text were identified. Two authors independently extracted data from identified sources. Results The seven stages of meta-ethnography described by Noblit and Hare (1988) are presented and integrated with key advancements from subsequent publications. Stages include starting the meta-synthesis, consideration of relevant studies, reading the studies and deciding on how they should be put together, translating the studies into one another, synthesising translations and expressing the synthesis. Conclusion Given the proliferation of qualitative methods in occupational therapy research, rigorous use of meta-ethnography has great potential to contribute to the research evidence base.
Risk Factors, Clinical Presentations, and Functional Impairments for Generalized Anxiety Disorder in Military Personnel and the General Population in Canada
Authors: Taillieu Tamara L. , Afifi Tracie O. , Turner Sarah , Cheung Kristene , Fortier Janique , Zamorski Mark , Sareen Jitender 
Published: January 2018

Objective: This study sought to examine differences in sociodemographic risk factors, comorbid mental conditions, clinical presentations, and functional impairments associated with past-year generalized anxiety disorder (GAD) between Canadian Armed Forces (CAF) Regular Force personnel and the Canadian general population (CGP). Method: Data were from 2 nationally representative surveys collected by Statistics Canada: 1) the Canadian Community Health Survey on Mental Health, collected in 2012 ( N = 25,113; response rate = 68.9%); and 2) the Canadian Forces Mental Health Survey, collected in 2013 ( N = 8,161; response rate = 79.8%). Results: The prevalence of lifetime and past-year GAD was significantly higher in the CAF (12.1% and 4.7%) than in the CGP (9.5% and 3.0%). Comorbid mental disorders were strongly associated with GAD in both populations. Although the content area of worry and the GAD symptoms endorsed were similar, CAF personnel were significantly more likely to endorse specific types of worries (i.e., success at school/work, social life, mental health, being away from home or loved ones, and war or revolution) and specific symptoms of GAD (i.e., restless, keyed up, or on edge and more irritable than usual) than civilians, after adjusting for sociodemographic covariates and comorbid mental disorders. CAF personnel with past-year GAD reported significantly higher functional impairment at home than civilians with past-year GAD. Conclusion: GAD is a substantial public health concern associated with significant impairment and disability in both military and civilian populations. GAD in military and civilian populations shows similarities and differences: Key similarities include its extensive comorbidity and significant functional impairment, whereas key differences include the focus of worries and symptom profile.
EU-Membership and the Border Trade in Alcohol in Southern Sweden
Authors: Trolldal Björn 
Published: January 2018

When Sweden joined the European Union on January 1, 1995, the personal import quotas for wine and strong beer were raised. This meant increased possibilities for Swedish consumers to buy alcohol at a lower price, mainly in Denmark and on the Continent. In this article the effects of the higher quotas on retail trade in the southern part of Sweden have been studied. These effects are considered to reflect the minimum increase in cross-border shopping for alcohol in the southern part of the country after the EU-membership. The decrease in retail sales, affected by the increased cross-border shopping, between 1994 and 1996 was equivalent to 2.7% of the total sales of alcohol officially registered in Sweden. Between 1995 and 1996, cross-border shopping seems to have increased to the same extent as it did between 1994 and 1995. The increase in cross-border shopping mainly affected the sale of strong beer, followed by sales of ordinary-strength beer, wine and spirits, in this order. Even citizens living 300–400 kilometres from the southernmost tip of Sweden seem to have increased their purchase of alcohol in Denmark and on the Continent. This article also gives estimates of the consumers' reaction to price changes in alcoholic beverages sold by the state-owned monopoly stores during 1986–1995, both in Sweden as a whole and in the southern regions. It appears that consumers will buy more wine and strong beer if the prices are reduced. Considering the fact that the higher import quotas at least to some extent can be viewed as a price reduction in the southern part of the country, it is very likely that cross-border consumers will buy more alcohol abroad than they will if they stay in Sweden. Against this background it is safe to assume that since Sweden joined the EU, cross-border shopping has increased by more than an amount equivalent to 2.7% of the total, officially registered alcohol sales in Sweden.
From Centralized to Local Alcohol Policy? Administrative Decentralization and the Role of Local Municipalities in Finnish Alcohol Policy
Authors: Sairanen Sanna , Sulkunen Pekka 
Published: January 2018

The main concern in the article is with the question of how far the administration of welfare policy in general and alcohol policy in particular has been decentralized from central government to the local level. The period under review extends from the abrogation of the Prohibition Act in 1932 up to the present day. For the part of alcohol policy, the development is measured on the basis of the changes that have taken place in alcohol legislation, specifically with regard to alcohol control and licensing. Separate treatment is given to municipal alcohol inspection and alcohol and temperance committees. The latitude of local self-government in welfare policy issues is described by reference to the government grant system. The resources allocated by central government to local municipalities may be earmarked for specific projects, or alternatively be granted for allocation according to the local municipality's own discretion. The article also introduces a case study on the alcohol policy decision-makers in a Finnish municipality in 1991–1994. Local municipalities have greater autonomy today in the implementation and funding of welfare services than they did during the formative years of the welfare state. It is possible that in the future Finnish municipalities will become increasingly differentiated in terms of both the quality and quantity of services. However, local municipalities still remain first and foremost service providers; it seems that they have not even wanted to assume responsibility for the advocacy and protection of moral-political democracy. The same applies to alcohol policy. For the most part, local municipalities have tried to shed their responsibilities and reduce their influence in alcohol policy decision-making. During the 1990s municipalities have no longer wanted to assume responsibility for alcohol control or for the processing of licensing and retail sales permits. The article concludes that local municipalities consider the lack of services a greater problem than the social or health problems associated with alcohol.
Public Discourse on Alcohol Policy and Tobacco Policy in Finland
Authors: Piispa Matti 
Published: January 2018

The article looks at public opinion in Finland on alcohol use and smoking and at people's views on strategies of intervention. The most common discourse in public debate on alcohol policy and tobacco policy underscores the importance of popular education. It is believed that significant and sustainable progress can only be achieved by providing information on the adverse effects of alcohol in terms of health risks and related social and cultural factors. The popular education discourse is often linked up with criticisms of policies based on prohibition and restrictions. A restrictive policy tends to be seen as patronizing, as a form of health terror that in effect encourages adverse behaviours and in this way exacerbates the problems of drinking and smoking. This line of argumentation occurs where restrictions on the sale of alcohol are concerned. Restrictive policies on smoking, by contrast, are widely accepted: in this case restrictions are seen as providing protection against environmental tobacco smoke or passive smoking. Public discourses on alcohol policy and tobacco policy reflect an elitist tradition of popular education which shows concern for the health habits of the “common folk”, but they also reflect the values of modern society and the modern individual. It is felt that prohibitions and restrictions violate the consumer's freedom of choice and self-determination and hamper the progress of civilization. Popular education, by contrast, is thought to give individuals the freedom they need and deserve to make their own choices, to decide for themselves. These views are prominent in public discourses on alcohol policy because alcohol use is currently very much a symbol of freedom and modernity in Finland. Smoking, on the other hand, is regarded as old-fashioned and vulgar, it has lost its status as a symbol of freedom and self-control. This has meant a more favourable cultural climate for a restrictive tobacco policy.
Article
Authors: Fjær Svanaug 
Published: January 2018

Svanaug Fjær: The European Union and Drug Policy. Integration through control and production of knowledge In this article the influence of EU initiatives on national drug policies is discussed with special attention paid to the separation between control and prevention in drug policy. At national levels, policy administration is separated between the ministries responsible for treatment and prevention and the ministries responsible for control and punishment. This separation is parallel to the division established by the pillar structure of the Treaty of the European Union. A study of the Europeanization processes at the central administration level in Sweden, Denmark and the Netherlands showed that the growth in co-operative activity in the EU has been largest in the Ministries of Justice, while, due to establishment of focal points in the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), the growth in the health sector has happened in administrative bodies outside of the ministries. The networks which are developed and the means available are different in the justice and health sectors. In the third pillar (justice), practical and technical cooperation have developed in the form of EUROPOL and the Early Warning System on Synthetic Drugs. Sharing of information and the development of a common knowledge-base seems to be the basis of first-pillar (health) cooperation. In the three countries studied the Ministries of Health, which traditionally have had a central position at the national level, seem to have been allotted a less important role in the international co-operation. It is, however, argued that the impact of co-operation in the EM-CDDA should not be underestimated. Both common control and the development of a European base of knowledge contribute to the integration process in the drug field, but the premises for the process are set by the demand for control.
Plasminogen replacement therapy for the treatment of children and adults with congenital plasminogen deficiency
Authors: Shapiro Amy D. , Nakar Charles , Parker Joseph M. , Albert Gary R. , Moran John E. , Thibaudeau Karen , Thukral Neelam , Hardesty Brandon M. , Laurin Pierre , Sandset Per Morten 
Published: January 2018

Key PointsThis is the first trial to evaluate the clinical utility of Glu-plasminogen in children and adults with congenital plasminogen deficiency. Glu-plasminogen achieves physiological levels of plasminogen activity coinciding with improved clinical efficacy and disease management.
Hereditary folate malabsorption due to a mutation in the external gate of the proton-coupled folate transporter SLC46A1
Authors: Aluri Srinivas , Zhao Rongbao , Lubout Charlotte , Goorden Susanna M. I. , Fiser Andras , Goldman I. David 
Published: January 2018

Key PointsAn N411K mutation in the external gate of the proton-coupled folate transporter within the aqueous channel results in impaired function. The N411K mutation produces a substrate-specific defect in transport, resulting in hereditary folate malabsorption.