bluuebunny/crossref_metadata_2025_split huggingface dataset:
Undernourished Children and Milk Lactose
Authors: Grenov Benedikte , Briend André , Sangild Per T. , Thymann Thomas , Rytter Maren H. , Hother Anne-Louise , Mølgaard Christian , Michaelsen Kim F. 
Published: February 2016

Background: Lactose is an important energy source in young mammals, and in fully breast-fed human infants, it constitutes around 40% of the total daily energy intake. The role of lactose in feeding of undernourished infants and young children is not well described. Objective: A narrative review of the potential positive and negative effects of lactose in the treatment of undernourished children. Methods: Searches were conducted using PUBMED and Web of Science up to July 2015. Relevant references in the retrieved articles were included. Results: Lactose may exhibit several health benefits in young children, including a prebiotic effect on the gut microbiota and a positive effect on mineral absorption. Studies in piglets suggest there might also be a stimulating effect on growth, relative to other carbohydrates. Lactose intolerance is a potential concern for undernourished children. Most undernourished children seem to tolerate the currently recommended (low lactose level) therapeutic foods well. However, a subgroup of severely undernourished children with secondary lactase deficiency due to severe diarrhea or severe enteropathy may benefit from products with even more restricted lactose content. At limited extra costs, lactose or lactose-containing milk ingredients may have beneficial effects if added to food products for undernourished children. Conclusions: Lactose may be an overlooked beneficial nutrient for young and undernourished children. Research is needed to define the balance between beneficial and detrimental effects of lactose in undernourished children at different ages and with different degrees of diarrhea and intestinal integrity.
Mayo Registry for Telemetry Efficacy in Arrest Study: An Assessment of the Utility of Telemetry in Predicting Clinical Decompensation
Authors: Snipelisky David , Ray Jordan , Matcha Gautam , Roy Archana , Harris Dana , Bosworth Veronica , Dumitrascu Adrian , Clark Brooke , Vadeboncoeur Tyler , Kusumoto Fred , Bowman Cammi , Burton M. Caroline 
Published: February 2016

Introduction: Our study assesses the utility of telemetry in identifying decompensation in patients with documented cardiopulmonary arrest. Methods: A retrospective review of inpatients who experienced a cardiopulmonary arrest from May 1, 2008, until June 30, 2014, was performed. Telemetry records 24 hours prior to and immediately preceding cardiopulmonary arrest were reviewed. Patient subanalyses based on clinical demographics were made as well as analyses of survival comparing patients with identifiable rhythm changes in telemetry to those without. Results: Of 242 patients included in the study, 75 (31.0%) and 110 (45.5%) experienced telemetry changes at the 24-hour and immediately preceding time periods, respectively. Of the telemetry changes, the majority were classified as nonmalignant (n = 50, 66.7% and n = 66, 55.5% at 24 hours prior and immediately preceding, respectively). There was no difference in telemetry changes between intensive care unit (ICU) and non-ICU patients and among patients stratified according to the American Heart Association telemetry indications. There was no difference in survival when comparing patients with telemetry changes immediately preceding and at 24 hours prior to an event (n = 30, 27.3% and n = 15, 20.0%) to those without telemetry changes during the same periods (n = 27, 20.5% and n = 42, 25.2%; P = .22 and .39). Conclusion: Telemetry has limited utility in predicting clinical decompensation in the inpatient setting.
Urinary tract infections in multiple sclerosis
Authors: Phé Véronique , Pakzad Mahreen , Curtis Carmel , Porter Bernadette , Haslam Collette , Chataway Jeremy , Panicker Jalesh N 
Published: February 2016

Background: Urinary tract infections (UTIs) are commonly reported by people with multiple sclerosis (PwMS) and significantly impact quality of life. Objective: To provide an overview of the problem of UTIs in PwMS and offer a practical approach for the diagnosis and management. Methods: A review of the literature through a Pubmed search up to October 2015 was performed using the following keywords: multiple sclerosis, neurogenic bladder, urinary tract infections, relapse, dipsticks, culture, recurrent and prevention. Results: Noteworthy topics include the definition of a confirmed symptomatic UTI as a positive urine culture defined by >105 colony-forming units (CFU)/mL or >104 CFU/mL if a urethral catheter urine sample is taken, or any count of bacteria in a suprapubic bladder puncture specimen, both in addition to symptoms including fever, pain, changes in lower urinary tract symptoms or neurological status. Urinalysis is useful to exclude a UTI; however, on its own is insufficient to confirm a UTI, for which urine culture is required. Experts advise asymptomatic UTIs should not be treated except in the context of an acute relapse. From international guidelines, there is no validated strategy to prevent recurrent UTIs in PwMS. Conclusion: This review provides an overview of the diagnosis, treatment and prevention of UTIs in the setting of multiple sclerosis (MS).
‘Unmarried Mothers’ in the Republic of Ireland
Authors: Garrett Paul Michael 
Published: February 2016

Summary During the summer of 2014 reports that a ‘septic tank grave’ containing ‘skeletons of 800 babies’ had been discovered on the site of a former home for ‘unmarried mothers’ in Tuam, County Galway appeared in the international press and social media. Doubts quickly began to surface around the assertion that the remains of children had, in fact, been ‘dumped’ in a ‘septic tank, but it is still important that responses to ‘unmarried mothers’ and their children are subject to contemporary scrutiny because substantial concerns clearly warrant investigation. In June 2014 the Minister for Children and Youth Affairs, in the Irish coalition government, announced the setting up of an inquiry. Findings Acknowledging the significance of historical and archival research for social work, the article provides a more expansive contextual account than that featured in the media coverage. The main focus is on policy and practice in relation to ‘unmarried mothers’ in the early years of the state and the establishment of quasi-penal Mother and Baby Homes. The lack of legal child adoption also restricted the meaningful choices available to expectant, unwed women in Ireland. Many, known to social workers as P.F.I.s (‘pregnant from Ireland’), decided to flee to England to give birth and have children placed for adoption. Drawing on the annual reports of the Catholic Protection and Rescue Society of Ireland, it is revealed that these women often faced being ‘repatriated’ back to Ireland. Applications The discussion serves to emphasise the vital significance of social history in comprehending ways of working with ‘troublesome’ populations.
Eccentric Exercise Versus Eccentric Exercise and Soft Tissue Treatment (Astym) in the Management of Insertional Achilles Tendinopathy
Authors: McCormack Joshua R. , Underwood Frank B. , Slaven Emily J. , Cappaert Thomas A. 
Published: February 2016

Background: Eccentric exercise is commonly used in the management of Achilles tendinopathy (AT) but its effectiveness for insertional AT has been questioned. Soft tissue treatment (Astym) combined with eccentric exercise could result in better outcomes than eccentric exercise alone. Hypothesis: Soft tissue treatment (Astym) plus eccentric exercise will be more effective than eccentric exercise alone for subjects with insertional AT. Study Design: Prospective randomized controlled trial. Level of Evidence: Level 2. Methods: Sixteen subjects were randomly assigned to either a soft tissue treatment (Astym) and eccentric exercise group or an eccentric exercise–only group. Intervention was completed over a 12-week period, with outcomes assessed at baseline, 4, 8, 12, 26, and 52 weeks. Outcomes included the Victorian Institute of Sport Assessment Achilles-Specific Questionnaire (VISA-A), the numeric pain rating scale (NPRS), and the global rating of change (GROC). Results: Significantly greater improvements on the VISA-A were noted in the soft tissue treatment (Astym) group over the 12-week intervention period, and these differences were maintained at the 26- and 52-week follow-ups. Both groups experienced a similar statistically significant improvement in pain over the short and long term. A significantly greater number of subjects in the soft tissue treatment (Astym) group achieved a successful outcome at 12 weeks. Conclusion: Soft tissue treatment (Astym) plus eccentric exercise was more effective than eccentric exercise only at improving function during both short- and long-term follow-up periods. Clinical Relevance: Soft tissue treatment (Astym) plus eccentric exercise appears to be a beneficial treatment program that clinicians should consider incorporating into the management of their patients with insertional AT.
Drug repurposing to target Ebola virus replication and virulence using structural systems pharmacology
Authors: Zhao Zheng , Martin Che , Fan Raymond , Bourne Philip E. , Xie Lei 
Published: February 2016

Abstract
Background
The recent outbreak of Ebola has been cited as the largest in history. Despite this global health crisis, few drugs are available to efficiently treat Ebola infections. Drug repurposing provides a potentially efficient solution to accelerating the development of therapeutic approaches in response to Ebola outbreak. To identify such candidates, we use an integrated structural systems pharmacology pipeline which combines proteome-scale ligand binding site comparison, protein-ligand docking, and Molecular Dynamics (MD) simulation.

Results
One thousand seven hundred and sixty-six FDA-approved drugs and 259 experimental drugs were screened to identify those with the potential to inhibit the replication and virulence of Ebola, and to determine the binding modes with their respective targets. Initial screening has identified a number of promising hits. Notably, Indinavir; an HIV protease inhibitor, may be effective in reducing the virulence of Ebola. Additionally, an antifungal (Sinefungin) and several anti-viral drugs (e.g. Maraviroc, Abacavir, Telbivudine, and Cidofovir) may inhibit Ebola RNA-directed RNA polymerase through targeting the MTase domain.

Conclusions
Identification of safe drug candidates is a crucial first step toward the determination of timely and effective therapeutic approaches to address and mitigate the impact of the Ebola global crisis and future outbreaks of pathogenic diseases. Further in vitro and in vivo testing to evaluate the anti-Ebola activity of these drugs is warranted.
Endothelial progenitor cells and burn injury – exploring the relationship
Authors: Banyard Derek A. , Adnani Blake O. , Melkumyan Satenik , Araniego Cheryl Ann , Widgerow Alan D. 
Published: February 2016

Abstract
Burn wounds result in varying degrees of soft tissue damage that are typically graded clinically. Recently a key participant in neovascularization, the endothelial progenitor cell, has been the subject of intense cardiovascular research to explore whether it can serve as a biomarker for vascular injury. In this review, we examine the identity of the endothelial progenitor cell as well as the evidence that support its role as a key responder after burn insult. While there is conflicting evidence with regards to the delta of endothelial progenitor cell mobilization and burn severity, it is clear that they play an important role in wound healing. Systematic and controlled studies are needed to clarify this relationship, and whether this population can serve as a biomarker for burn severity.
High-frequency Rayleigh-wave tomography using traffic noise from Long Beach, California
Authors: Chang Jason P. , de Ridder Sjoerd A. L. , Biondi Biondo L. 
Published: February 2016

Using a dense seismic array in Long Beach, California, we have investigated the effectiveness of using traffic noise for passive subsurface imaging. Spectral analysis revealed that traffic-induced vibrations dominate the ambient seismic noise field at frequencies between 3 and 15 Hz. Using the ambient-noise crosscorrelation technique at these frequencies, we have extracted fundamental- and first-order-mode Rayleigh waves generated by Interstate 405 and local roads. We picked group traveltimes associated with the fundamental mode and used them in a straight-ray tomography procedure to produce group velocity maps at 3.0 and 3.5 Hz. The velocity trends in our results corresponded to shallow depths and coincided well with lithologies outlined in a geologic map of the survey area. The most prominent features resolved in our velocity maps were the low velocities to the north corresponding to less-consolidated materials, high velocities to the south corresponding to more-consolidated materials, a low-velocity zone corresponding to artificial fill in Alamitos Bay, and a low-velocity linear feature in the Newport-Inglewood Fault Zone. Our resulting near-surface velocities can be useful for identifying regions that are susceptible to serious damage during earthquake-related shaking.
Salinity dependence of the complex surface conductivity of the Portland sandstone
Authors: Niu Qifei , Revil André , Saidian Milad 
Published: February 2016

Induced polarization can be used to estimate surface conductivity by assuming a universal linear relationship between the surface and quadrature conductivities of porous media. However, this assumption has not yet been justified for conditions covering a broad range of fluid conductivities. We have performed complex conductivity measurements on Portland sandstone, an illite- and kaolinite-rich sandstone, at 13 different water salinities (NaCl) over the frequency range of 0.1 Hz to 45 kHz. The conductivity of the pore water [Formula: see text] affected the complex surface conductivity mainly by changing the tortuosity of the conduction paths in the pore network from high to low salinities. As the fluid conductivity decreases, the magnitude of the surface conductivity and quadrature conductivity was observed to decrease. At relatively high salinities ([Formula: see text]), the ratio between the surface conductivity and quadrature conductivity was roughly constant. At low salinities ([Formula: see text]), the ratio decreased slightly with the decrease of the salinity. A Stern layer polarization model was combined with the differential effective medium (DEM) theory to describe this behavior. The tortuosity entering the complex surface conductivity was salinity dependent following the prediction of the DEM theory. At high salinity, it reached the value of the bulk tortuosity of the pore space given by the product of the intrinsic formation factor and the connected porosity. The relaxation time distributions were also obtained at different salinities by inverting the measured spectra using a Warburg decomposition. The mode of the relaxation time probability distribution found a small but clear dependence on the salinity. This salinity dependence can be explained by considering the ions exchange between Stern and diffuse layers during polarization of the former. The pore-size distribution obtained from the distribution of the relaxation time agreed with the pore-size distribution from nuclear magnetic resonance measurements.
Demerara Rise, offshore Suriname: Magma-rich segment of the Central Atlantic Ocean, and conjugate to the Bahamas hot spot
Authors: Reuber Kyle R. , Pindell Jim , Horn Brian W. 
Published: February 2016

The Demerara Rise is a prominent bathymetric feature that has been considered as a broad expression of shallow continental basement and used in conjunction with the Guinea Plateau as a pinning point for circum-Atlantic plate reconstructions. Previously, shallow-penetration, poorly imaged seismic data over the Demerara Rise were modeled with the lower sequences interpreted as continental crust at relatively shallow depths. However, new long-offset, deeply penetrating seismic data provide evidence that basement nearly or entirely comprises excessively thick volcanic strata (approximately 21 km). Seismic character and geometry, 2D gravity modeling, and volcanic margin analogs were used to identify unfaulted, convex-upward seaward dipping reflector (SDR) packages. These steeply dipping (approximately 20°) igneous successions are westwardly divergent, and occur as offlapping reflector sets in trains as long as 250 km. This rift-related volcanism now recognized at the Demerara Rise was probably conjugate to syn-rift volcanism in South Florida/Great Bahama Bank, and from this we have predicted a volcanic element for the Guinea Plateau. This volcanism could be linked to a Bahamas hot spot at the initial opening of the Central Atlantic. Six SDR packages have been interpreted below the Late Jurassic-Early Cretaceous carbonate section of the rise, indicating that the early volcanism produced a marine substrate upon which the subsequent carbonate bank section developed. We have inferred that this Early Cretaceous volcanic/carbonate margin continued into the Guinea Plateau of West Africa. The pre-Aptian section was inverted and peneplained with a strong angular unconformity prior to the Early Cretaceous opening of the Equatorial Atlantic seaway. The newly identified Central Atlantic volcanic margin of the Demerara Rise holds implications of a volcanic origin for its conjugate margins. We have confirmed a voluminous magma-rich opening of the southeastern Central Atlantic.
Analysis of coelom development in the sea urchinHolopneustes purpurescensyielding a deuterostome body plan
Authors: Morris Valerie B. 
Published: February 2016

ABSTRACTAn analysis of early coelom development in the echinoid Holopneustes purpurescens yields a deuterostome body plan that explains the disparity between the pentameral plan of echinoderms and the bilateral plans of chordates and hemichordates, the three major phyla of the monophyletic deuterostomes. The analysis shows an early separation into a medial hydrocoele and lateral coelomic mesoderm with an enteric channel between them before the hydrocoele forms the pentameral plan of five primary podia. The deuterostome body plan thus has a single axial or medial coelom and a pair of lateral coeloms, all surrounding an enteric channel, the gut channel. Applied to the phyla, the medial coelom is the hydrocoele in echinoderms, the notochord in chordates and the proboscis coelom in hemichordates: the lateral coeloms are the coelomic mesoderm in echinoderms, the paraxial mesoderm in chordates and the lateral coeloms in hemichordates. The plan fits frog and chick development and the echinoderm fossil record, and predicts genes involved in coelomogenesis as the source of deuterostome macroevolution.
Genetic basis of hindlimb loss in a naturally occurring vertebrate model
Authors: Don Emily K. , de Jong-Curtain Tanya A. , Doggett Karen , Hall Thomas E. , Heng Benjamin , Badrock Andrew P. , Winnick Claire , Nicholson Garth A. , Guillemin Gilles J. , Currie Peter D. , Hesselson Daniel , Heath Joan K. , Cole Nicholas J. 
Published: February 2016

ABSTRACTHere we genetically characterise pelvic finless, a naturally occurring model of hindlimb loss in zebrafish that lacks pelvic fin structures, which are homologous to tetrapod hindlimbs, but displays no other abnormalities. Using a hybrid positional cloning and next generation sequencing approach, we identified mutations in the nuclear localisation signal (NLS) of T-box transcription factor 4 (Tbx4) that impair nuclear localisation of the protein, resulting in altered gene expression patterns during pelvic fin development and the failure of pelvic fin development. Using a TALEN-induced tbx4 knockout allele we confirm that mutations within the Tbx4 NLS (A78V; G79A) are sufficient to disrupt pelvic fin development. By combining histological, genetic, and cellular approaches we show that the hindlimb initiation gene tbx4 has an evolutionarily conserved, essential role in pelvic fin development. In addition, our novel viable model of hindlimb deficiency is likely to facilitate the elucidation of the detailed molecular mechanisms through which Tbx4 functions during pelvic fin and hindlimb development.
The ESCRT-II proteins are involved in shaping the sarcoplasmic reticulum in C. elegans
Authors: Lefebvre Christophe , Largeau Céline , Michelet Xavier , Fourrage Cécile , Maniere Xavier , Matic Ivan , Legouis Renaud , Culetto Emmanuel 
Published: February 2016

ABSTRACT
The sarcoplasmic reticulum is a network of tubules and cisternae localized in close association with the contractile apparatus, and regulates Ca2+ dynamics within striated muscle cell. The sarcoplasmic reticulum maintains its shape and organization despite repeated muscle cell contractions, through mechanisms which are still under investigation. The ESCRT complexes are essential to organize membrane subdomains and modify membrane topology in multiple cellular processes. Here, we report for the first time that ESCRT-II proteins play a role in the maintenance of sarcoplasmic reticulum integrity in C. elegans. ESCRT-II proteins colocalize with the sarcoplasmic reticulum marker ryanodine receptor UNC-68. The localization at the sarcoplasmic reticulum of ESCRT-II and UNC-68 are mutually dependent. Furthermore, the characterization of ESCRT-II mutants revealed a fragmentation of the sarcoplasmic reticulum network, associated with an alteration of Ca2+ dynamics. Our data provide evidence that ESCRT-II proteins are involved in sarcoplasmic reticulum shaping.
Temporal control of bidirectional lipid-droplet motion in Drosophila depends on the ratio of kinesin-1 and its co-factor Halo
Authors: Arora Gurpreet K. , Tran Susan L. , Rizzo Nicholas , Jain Ankit , Welte Michael A. 
Published: February 2016

ABSTRACT
During bidirectional transport, individual cargoes move continuously back and forth along microtubule tracks, yet the cargo population overall displays directed net transport. How such transport is controlled temporally is not well understood. We analyzed this issue for bidirectionally moving lipid droplets in Drosophila embryos, a system in which net transport direction is developmentally controlled. By quantifying how the droplet distribution changes as embryos develop, we characterize temporal transitions in net droplet transport and identify the crucial contribution of the previously identified, but poorly characterized, transacting regulator Halo. In particular, we find that Halo is transiently expressed; rising and falling Halo levels control the switches in global distribution. Rising Halo levels have to pass a threshold before net plus-end transport is initiated. This threshold level depends on the amount of the motor kinesin-1: the more kinesin-1 is present, the more Halo is needed before net plus-end transport commences. Because Halo and kinesin-1 are present in common protein complexes, we propose that Halo acts as a rate-limiting co-factor of kinesin-1.