bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Long Noncoding RNA Transcriptome ofDictyostelium discoideumDevelopment
Authors: Rosengarten Rafael D , Santhanam Balaji , Kokosar Janez , Shaulsky Gad 
Published: February 2017

AbstractDictyostelium discoideum live in the soil as single cells, engulfing bacteria and growing vegetatively. Upon starvation, tens of thousands of amoebae enter a developmental program that includes aggregation, multicellular differentiation, and sporulation. Major shifts across the protein-coding transcriptome accompany these developmental changes. However, no study has presented a global survey of long noncoding RNAs (ncRNAs) in D. discoideum. To characterize the antisense and long intergenic noncoding RNA (lncRNA) transcriptome, we analyzed previously published developmental time course samples using an RNA-sequencing (RNA-seq) library preparation method that selectively depletes ribosomal RNAs (rRNAs). We detected the accumulation of transcripts for 9833 protein-coding messenger RNAs (mRNAs), 621 lncRNAs, and 162 putative antisense RNAs (asRNAs). The noncoding RNAs were interspersed throughout the genome, and were distinct in expression level, length, and nucleotide composition. The noncoding transcriptome displayed a temporal profile similar to the coding transcriptome, with stages of gradual change interspersed with larger leaps. The transcription profiles of some noncoding RNAs were strongly correlated with known differentially expressed coding RNAs, hinting at a functional role for these molecules during development. Examining the mitochondrial transcriptome, we modeled two novel antisense transcripts. We applied yet another ribosomal depletion method to a subset of the samples to better retain transfer RNA (tRNA) transcripts. We observed polymorphisms in tRNA anticodons that suggested a post-transcriptional means by which D. discoideum compensates for codons missing in the genomic complement of tRNAs. We concluded that the prevalence and characteristics of long ncRNAs indicate that these molecules are relevant to the progression of molecular and cellular phenotypes during development.
BASE CARTOGRÁFICA DIGITAL COMO INSTRUMENTO PARA A IDENTIFICAÇÃO DE ÁREAS SUSCETÍVEIS À EROSÃO E MOVIMENTOS DE MASSA EM JOÃO PESSOA (PB), BRASIL
Authors: De Oliveira Vital Saulo Roberto , Ferreira Bruno , Girão Osvaldo , Lima dos Santos Caio , Carvalho-Nunes Fábio , De Almeida Silveira Thyago 
Published: February 2017

O presente estudo teve como objetivo, realizar a detecção dos riscos de erosão e movimentos de massa no município de João Pessoa (PB), a partir de técnicas de geoprocessamento. Para isso, foram confeccionados mapas temáticos contendo informações referentes à cobertura do solo, declividade, exposição de vertentes e solos, gerados a partir de imagens do satélite OLI/Landsat e de cartas topográficas. A partir dessas informações foi possível observar que os riscos analisados são basicamente representados por erosões lineares e por desmonte nas encostas e terraços fluviais. Os resultados obtidos mostram uma série de riscos no cotidiano da população residente nessas áreas, merecendo ações que visem a mitigação ou extinção desses riscos. Entende-se assim, que esta temática carece da realização de estudos mais detalhados que ajudem na caracterização, previsão, monitoramento, recuperação e extinção desses problemas socioambientais.
A SOCIOECONOMIA DA COMUNIDADE RURAL FAZENDA DO POVO DE IPIAÚ, BAHIA, BRASIL
Authors: Bruno-Lima Nelma , Aguiar-Bahia de Paulo César , Profice-Cabicieri Cristiana , Ferraz-Ferreira Marcelo Inácio 
Published: February 2017

O principal objetivo dessa pesquisa foi analisar a realidade socioeconômica da Comunidade Rural Fazenda do Povo de Ipiaú, Bahia, no contexto da sua sustentabilidade ambiental em relação à socioeconomia municipal e regional. Analisaram-se, para isso, indicadores socioeconômicos da região, do município de Ipiaú, e da comunidade. Os resultados apontaram situação positiva da comunidade no que se refere ao nível de escolaridade, comparando-se à realidade de outros assentamentos de reforma agrária; à questão da renda e da renda per capta; à baixa dependência de benefícios sociais do Governo; e à ocupação do trabalho. E apontaram como negativo a grande frequência de agroquímicos utilizados no manejo da produção.
LA AMIGABILIDAD DE LA CIUDAD DE HEREDIA CON LOS ANCIANOS, MEDIDA A PARTIR DE SUS CARACTERÍSTICAS FÍSICAS
Authors: Alfaro-Sánchez Marvin 
Published: February 2017

Esta investigación trata sobre la medición de la amigabilidad de la ciudad de Heredia con los ancianos a partir de cuatro variables; la calidad de los barrios, entendidos como el entorno inmediato de los ancianos, la calidad y el acceso a las áreas verdes en la ciudad, a la ciudad utilizando transporte público y a una serie de servicios urbanos básicos en la vida de los ancianos, cada una medida a través de indicadores simples y combinados. Los resultados muestran que la ciudad de Heredia tiene una amigabilidad apenas aceptable, con áreas con baja y mediana amigabilidad, fruto de un pobre acceso a áreas verdes, de altos niveles de ruido, de flujo vehicular y de algunos servicios con poca accesibilidad.
CARTOGRAFÍA DE AFECTACIÓN POR AMENAZAS NATURALES EN EL CANTÓN DE POÁS, COSTA RICA
Authors: Barrantes-Castillo Gustavo , Quesada-Román Adolfo 
Published: February 2017

A pesar de la existencia de reportes históricos, recopilaciones, bases de datos e informes, no se dispone en el país de un estudio que sintetice y distribuya espacialmente la información sobre afectación histórica por amenazas naturales. Por medio de una compilación y georreferenciación de toda la información disponible sobre impactos por amenazas naturales en el cantón de Poás, fue posible construir indicadores espaciales de afectación para los eventos registrados (caída de ceniza, gases volcánicos, terremotos, inundaciones y deslizamientos). Estos fueron estandarizados en cinco clases (muy baja, baja, moderada, alta y muy alta), con lo que se construyó un indicador de máxima afectación por eventos naturales históricos para dicha unidad política- administrativa a partir de la sobreposición de los registros de desastres. El resultado de este estudio muestra una tendencia al incremento de las afectaciones por amenazas naturales de sur a norte, lo que es consecuente con la distribución de las lluvias, las pendientes, así como la proximidad con fuentes sísmicas y volcánicas. Un patrón distinto mostraron las inundaciones rápidas y los deslizamientos que se relacionan con la presencia de valles fluviales encañonados con fuertes pendientes en microcuencas alargadas y pequeñas sobre depósitos volcánicos recientes.
LA FALLA ACTIVA GUANE, CUBA OCCIDENTAL
Authors: Cotilla-Rodríguez Mario Octavio 
Published: February 2017

Se presentan nuevos datos que confirman la actividad de la falla Guane. Ésta es una estructura activa de interior de placa en la Unidad Neotectónica Occidental de Cuba con ~100. La magnitud máxima de los terremotos es 6.2 con periodo de recurrencia de ~130 años. El mecanismo tectónico de reajustes en el interior de la placa es a través de fallas y rotación de bloques, que producen terremotos como los de: 23.01.1880 (San Cristóbal, Cuba), 16.12.1982 (Torriente - Jagüey Grande, Matanzas) y 09.03.1995 (Pedro Pí - San José de las Lajas, La Habana). Esos 3 terremotos se pueden explicar a partir de procesos transpresivos de las placas Caribe y Norteamérica en las fallas Swan y Oriente, y de la transmisión de esfuerzos hacia el megabloque Cuba.
MORPHOTECTONIC INTERPRETATION OF THE 23-02-2015 ALBACETE EARTHQUAKE, SPAIN
Authors: Cotilla-Rodríguez Mario Octavio , Córdoba-Barba Diego 
Published: February 2017

En el megabloque Península Ibérica ocurrió un terremoto (23.02.2015). El evento es del tipo de interior de placa (Mw= 4,7 / h= 17 km), donde existe una zona de deformación morfotectónica. El epicentro y el mecanismo focal del tipo normal y deslizamiento lateral, fueron determinados en el bloque Albacete. Este último con tendencia al levantamiento dentro de los mesobloques Albacete y Cuenca.
TASAS DE GENERACIÓN Y CARACTERIZACIÓN DE RESIDUOS SÓLIDOS ORDINARIOS EN CUATRO MUNICIPIOS DEL ÁREA METROPOLITANA COSTA RICA
Authors: Herrera-Murillo Jorge , Rojas-Marín José Félix , Anchía-Leitón Deivis 
Published: February 2017

Se determinó la tasa de generación y caracterización de residuos sólidos ordinarios, en el sector residencial y comercial de 04 municipios ubicados geográficamente dentro del Gran Área Metropolitana de Costa Rica. Para ello, en el período 2014-2015, se realizaron muestreos en un número representativo de viviendas y comercios durante 07 días consecutivos. La tasa de generación promedio ponderada de residuos para el área de estudio resultó ser de 0,59 kg/hab-día. Los residuos sólidos generados presentan como componentes mayoritarios: orgánicos 55,9%, seguidos de materiales con alto potencial para ser reciclados o utilizados como combustibles (plásticos 10,2%, papel y cartón 10,4%). El contenido de humedad promedio en los residuos fue de 58,7% en masa (mínimo 54% en Alajuela y máximo 63% en Barva), de la cual hasta un 67% puede ser atribuible a residuos orgánicos biodegradables. El peso volumétrico promedio de los residuos resultó de 155 kg/m3 (mínimo de 141 en Belén y máximo de 163 en San José). Se evidenció que existen diferencias significativas en la composición de residuos sólidos para los sectores comerciales y residenciales, principalmente en la fracción orgánica, papel, cartón y plástico.
The Values of Moral Learning in “Ketika Cinta Bertasbih” Novel Written by Habiburrahman El Shirazy
Authors: Mulyadi Mulyadi 
Published: February 2017

A novel written by Habiburrahman El Shirazy “Ketika Cinta Bertasbih” (when love is connected to God) is decorated by a variety of ideas, values and ways of life. This novel does not only provide narrative story entertained with Islamic values, but also served as media to form public and readers’ morals. Because the story line presented in this novel contained an overview of everyday life containing of moral learning, therefore, it is very interesting to be studied. The current study seeks to uncover: 1) the value of moral learning and value of worship to God’ 2) the value of self moral learning. The type of research is Library Research using discourse analysis method (content analysis). It was found out that (1) The moral value of learning to the God contained a message of faith with arguments through the universe. It let worship of God, be grateful and stay away from vanity. (2) The value of self-moral learning included the value patient, persevering, self-authority, high optimistic, responsibility and self-firm.
The Correlation between Indonesian Students’ Vocabulary Mastery and Their Reading Comprehension
Authors: Hayati Amal 
Published: February 2017

Exploring students’ background knowledge in pre-reading activities suggests the importance of interaction in the process of meaning making which requires appropriate vocabulary. Although many factors constitute students’ comprehension, vocabulary should be the main concern in EFL reading classes. Consistence with this premise, the current study was aimed at proving the correlation between students’ vocabulary mastery and their reading achievement at the fourth semester of STKIP Dharma Bakti Lubuk Alung. This correlational study involved 70 students taken through cluster random sampling. Vocabulary and reading test were employed to determine the correlation between students’ vocabulary mastery and their reading comprehension. Through Correlation of Product Moment, coefficient correlation between two variables was found to be 0.61 with index correlation in r-table was 0.1617 for α= 0.05, suggesting that the coefficient correlation between two variables (rxy) t-calculated was bigger than t-table. It means that H1 was accepted and H0 was rejected. In conclusion, there was a positive correlation between students’ vocabulary mastery and their reading comprehension at the fourth semester students of STKIP Dharma Bakti Lubuk Alung
KETIDAKSTABILAN BESARAN STOK IKAN DARI MODEL PRODUKSI SURPLUS
Authors: Atmaja Suherman Banon 
Published: February 2017

Selama ini, kerangka pengelolaan sumber daya ikan berdasarkan pada titik acuan nilai potensi dan kriteria maksimum (maximum sustainable yield), mengabaikan laju pertumbuhan stok ikan dan tanpa memperhatikan dinamika perikanan yang terjadi. Dari kombinasi data yang tersedia diperoleh hasil besaran nilai stok ikan yang bersifat dinamis, akibat perubahan yang terjadi pada parameter–parameter model produksi surplus. Tingkat maximum sustainable yield menunjukkan CMSY darimetode Gompertz lebih tinggi dibandingkan dengan metode logistik, sebaliknya tingkat EMSY lebih rendah dibandingkan dengan metode logistik. Konsekuensi perbedaan tersebut menghasilkan tingkat BMSY dan tercapai puncak titik jenuh dari perikanan pukat cincin berbeda, untuk metode Gompertz (37% dari biomassa awal) terjadi pada kurun waktu tahun 1978 sampai dengan 1981, sedangkan untuk metode logistik (50% dari biomassa awal) terjadi pada kurun waktu tahun 1990 sampai dengan 1992. Kondisi trend biomassa menunjukkan penurunan biomassa berkisar 92 sampai dengan 96,5% dari biomassa awal untuk metode Gompertz, sedangkan untuk metode logistik berkisar 70 sampai dengan 93%. Tampak perkembangan perikanan pukat cincin catch effort mengikuti fungsi pertumbuhan logistik daripada fungsi pertumbuhan Gompertz. Bagaimanapun, penyusutan stok ikan pelagis didukung oleh trend hasil tangkapan yang menurun, sedangkan hari operasi cenderung meningkat. During the time, framework of fisheries resources management was based on reference point of potency value and criteria (maximum sustainable yield), while net growth of fish stock and fisheries dynamics have been ignored. From data combination available obtaining result of size of fish stocks was dynamic due to change of parameters of surplus production. The Level maximum sustainable yield showes that CMSY method of Gompertz was higher than logistics method, on the contrary EMSY compared to lower than logistics method. Consequently, these results were obtained the level of BMSY (biomass at level maximum sustainable yield) and the peaks of exploitation from purse seine fishery were also diffrent, for Gompertz method revealed that the level of BMSY (37% from initially biomass) occurred in the period of 1978 to 1981, while logistics method (50% from initially biomass) occurred in the period of 1990 to 1992. Trend biomass in state of decline reached 92 to 96,5% from intially biomass for Gompertz method, while for the method of logistics reached 70 to 93% from intially biomass. Seems that the development of purse seine fisheries (catch effort) followed function growth logistics rather than the function growth Gompertz. However, the decrease of fish stock pelagic supported by the catch of pelagic fish showed a declining trend, while fishing days have tend to increase.
ASPEK BIOLOGI DAN DAERAH PENANGKAPAN CUCUT BOTOL (Squalus sp.) YANG TERTANGKAP DI PERAIRAN SAMUDERA HINDIA
Authors: Dharmadi Dharmadi , Fahmi Fahmi 
Published: February 2017

Penelitian mengenai keragaman jenis Elasmobranchi dilakukan pada bulan Januari sampai dengan Desember 2002 di pelabuhan-pelabuhan perikanan PPI Cilacap, TPI Palabuhanratu, TPI Kedonganan-Bali, dan PPI Tanjung Luar-Lombok Timur. Cucut botol Squalus sp. merupakan jenis cucut laut dalam yang paling sering dijumpai selama penelitian berlangsung. Hasil penelitian menunjukkan bahwa cucut botol betina lebih sering tertangkap dibandingkan cucut jantan pada setiap waktu pengamatan. Frekuensi panjang cucut botol tertinggi dijumpai pada bulan Juni danAgustus yaitu berkisar antara 62 sampai dengan 68 cm. Nisbah kelamin cucut botol antara jantan betina selama pengamatan adalah 1:1,83. Hubungan antara panjang total tubuh dan panjang klasper cenderung linier dengan nilai R2=0,634326. Puncak musim penangkapan cucut botol terjadi sekitar bulan Agustus. Sedangkan daerah penangkapan cucut botol adalah di perairan Samudera Hindia. A study on diversity Elasmobranchi of was conducted using market surveys method from January to December 2002 at several fish landings in southern Indonesia, i.e. the Cilacap, Palabuhanratu, Kedonganan- Bali, and Tanjung Luar-East Lombok landing sites.A deep water shark, Indonesian shortnose spurdog (Squalus sp.), was the most common deep water sharks captured in the area during the study. Results show that females sharks were caught more frequent at every observation than those of males. The most abundant of Indonesian shortnose spurdog was recorded in June and August ranging from 62 to 68 cm in total length. Sex ratio between males and females of Squalus sp. during the study was 1:1.83, and the relationship between total length and claspers length of dogfish shark was linier (R2=0.634326). The peak fishing season of Indonesian spurdog was occurred in August with the fishing area was in the Indian Ocean.
SEBARAN DAN KEPADATAN UDANG MANTIS (Carinosquilla spinosa) DI PERAIRAN ARAFURA
Authors: Wedjatmiko Wedjatmiko 
Published: February 2017

Udang mantis (Carinosquilla spinosa) merupakan salah satu komoditas perikanan laut dan termasuk dalam jenis udang, dengan ordo Stomatopoda. Secara umum, komoditas tersebut sering disebut dengan udang ronggeng, udang mantis, dan udang pengko. Penelitian terhadap penyebaran dan densitas udang mantis (Carinosquilla spinosa) di perairan Arafura dilaksanakan pada bulan Oktober sampai dengan Nopember 2003. Alat tangkap yang digunakan dalam penelitian ini adalah jenis alat tangkap khusus untuk udang komersial (trawl). Lokasi penelitian difokuskan di sekitar muara Sungai Digul dengan kordinat 6°–7,5° LS dan 137°–138° BT, yang merupakan daerah penangkapan udang komersial. Hasil penelitian menunjukkan bahwa penyebaran udang mantis terdapat di semua stasiun penelitian, dengan dominasi hasil tangkapan tepat di depan muara Sungai Digul, dengan densitas sekitar 28,75 sampai dengan 51,50 kg per jam. Sedangkan rata-rata hasil tangkapan udang mantis di perairan Arafura adalah 14 kg per jam. Ukuran panjang rata-rata udang mantis secara total adalah 11,00 cm dengan bobot rata-rata per ekor 20,83 g dari kisaran 6,1 sampai dengan 25,0 cm. Modus kelas frekuensi panjang terjadi pada ukuran 9,1 sampai dengan 10 cm. Mantis shrimp (Carinosquilla spinosa) is one of marine fisheries commodity and includes in crustaceans. In generally this shrimp is called udang ronggeng or udang pengko (local named). Research on mantis shrimp (Carinosquilla spinosa) resources in Arafura waters was conducted during October to November 2003. The fishing gear used was stern trawl with length of head rope 35 m and ground rope 41 m. Research location in Arafura waters, was conducted closed to comercial shrimp catch area by cordinat 6°–7,5° S dan 137°–138° E. Result of the research shows that distribution of the shrimp was on whole station, but dominan density was closed to Digul Estuary, with catch rate 28,75 to 51,50 kg per hour. The average catch rate every station was 14 kg per hour and the size 11,00 cm and 20,83 g. Minimum size of mantis shrimp was 6,1 cm, and maximum size was 25 cm.
Association Between Tumor Progression Endpoints and Overall Survival in Patients with Advanced Neuroendocrine Tumors
Authors: Ter-Minassian Monica , Zhang Sui , Brooks Nichole V. , Brais Lauren K. , Chan Jennifer A. , Christiani David C. , Lin Xihong , Gabriel Sylvie , Dinet Jérôme , Kulke Matthew H. 
Published: February 2017

Abstract

Endpoints related to tumor progression are commonly used in clinical trials of novel therapeutic agents for neuroendocrine tumors (NETs). Whether improved tumor control translates into improved overall survival (OS), however, is uncertain. We assessed associations between tumor progression endpoints and OS in observational cohorts of patients with advanced neuroendocrine tumors treated with somatostatin analogs or with everolimus. We identified 440 patients with advanced NET who had received treatment with single-agent somatostatin analogs and 109 patients treated with everolimus, all of whom were treated at our institution and were evaluable for both tumor progression and survival. We assessed associations between progression-free survival (PFS) and OS by using the Kendall tau test, and we assessed associations between tumor progression and OS by using a landmark analysis. In the 440 patients treated with somatostatin analogs, we observed a significant correlation between PFS and OS by using the Kendall tau test (0.31; p &lt; .0001). Additionally, the development of progressive disease was associated with OS in a landmark analysis, at landmark times of 6, 12, 18, and 24 months. In the 109 patients treated with everolimus, we similarly observed a significant correlation between PFS and OS by using the Kendall tau test (0.44; p &lt; .0001) and associations between progressive disease and OS by using a landmark analysis at 3, 6, and 12 months. In these observational cohorts of patients with metastatic NET treated with single-agent somatostatin analogs or everolimus, longer times to disease progression and longer PFS were both associated with improved OS. Our findings support the continued use of disease progression endpoints in NET clinical trials.
Key Lessons Learned from Moffitt’s Molecular Tumor Board: The Clinical Genomics Action Committee Experience
Authors: Knepper Todd C. , Bell Gillian C. , Hicks J. Kevin , Padron Eric , Teer Jamie K. , Vo Teresa T. , Gillis Nancy K. , Mason Neil T. , McLeod Howard L. , Walko Christine M. 
Published: February 2017

AbstractBackgroundThe increasing practicality of genomic sequencing technology has led to its incorporation into routine clinical practice. Successful identification and targeting of driver genomic alterations that provide proliferative and survival advantages to tumor cells have led to approval and ongoing development of several targeted cancer therapies. Within many major cancer centers, molecular tumor boards are constituted to shepherd precision medicine into clinical practice.Materials and MethodsIn July 2014, the Clinical Genomics Action Committee (CGAC) was established as the molecular tumor board companion to the Personalized Medicine Clinical Service (PMCS) at Moffitt Cancer Center in Tampa, Florida. The processes and outcomes of the program were assessed in order to help others move into the practice of precision medicine.ResultsThrough the establishment and initial 1,400 patients of the PMCS and its associated molecular tumor board at a major cancer center, five practical lessons of broad applicability have been learned: transdisciplinary engagement, the use of the molecular report as an aid to clinical management, clinical actionability, getting therapeutic options to patients, and financial considerations. Value to patients includes access to cutting-edge practice merged with individualized preferences in treatment and care.ConclusionsGenomic-driven cancer medicine is increasingly becoming a part of routine clinical practice. For successful implementation of precision cancer medicine, strategically organized molecular tumor boards are critical to provide objective evidence-based translation of observed molecular alterations into patient-centered clinical action. Molecular tumor board implementation models along with clinical and economic outcomes will define future treatment standards.