bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Water Balance Representation in Urban‐PLUMBER Land Surface Models
Authors: Jongen H. J. , Lipson M. , Teuling A. J. , Grimmond S. , Baik J.‐J. , Best M. , Demuzere M. , Fortuniak K. , Huang Y. , De Kauwe M. G. , Li R. , McNorton J. , Meili N. , Oleson K. , Park S.‐B. , Sun T. , Tsiringakis A. , Varentsov M. , Wang C. , Wang Z.‐H. , Steeneveld G. J. 
Published: September 2024

AbstractUrban Land Surface Models (ULSMs) simulate energy and water exchanges between the urban surface and atmosphere. However, earlier systematic ULSM comparison projects assessed the energy balance but ignored the water balance, which is coupled to the energy balance. Here, we analyze the water balance representation in 19 ULSMs participating in the Urban‐PLUMBER project using results for 20 sites spread across a range of climates and urban form characteristics. As observations for most water fluxes are unavailable, we examine the water balance closure, flux timing, and magnitude with a score derived from seven indicators expecting better scoring models to capture the latent heat flux more accurately. We find that the water budget is only closed in 57% of the model‐site combinations assuming closure when annual total incoming fluxes (precipitation and irrigation) fluxes are within 3% of the outgoing (all other) fluxes. Results show the timing is better captured than magnitude. No ULSM has passed all water balance indicators for any site. Models passing more indicators do not capture the latent heat flux more accurately refuting our hypothesis. While output reporting inconsistencies may have negatively affected model performance, our results indicate models could be improved by explicitly verifying water balance closure and revising runoff parameterizations. By expanding ULSM evaluation to the water balance and related to latent heat flux performance, we demonstrate the benefits of evaluating processes with direct feedback mechanisms to the processes of interest.
Seasonal and Solar Cycle Dependency of Relationship Between Equatorial Plasma Bubbles and Rayleigh‐Taylor Instability Growth Rate
Authors: Vital L. F. R. , Takahashi H. , Barros D. , Carmo C. S. , Carrasco A. J. , Wrasse C. M. , Figueiredo C. A. O. B. 
Published: September 2024

AbstractThe relationship between the post‐sunset equatorial Plasma Bubbles (EPBs) and the Rayleigh‐Taylor instability growth rates was studied by means of the occurrence probabilities. EPB observations were obtained through the Rate of Total Electron Content Index (ROTI) measured by ground‐based Global Navigation Satellite System (GNSS) receivers in the South American equatorial region. Data from the period 2013 to 2022 were utilized. The calculations were based on F‐layer vertical drift measurements obtained from the São Luís ionosonde (2.33°S, 44.2°W, dip angle: −0.5°), the International Reference Ionosphere model (IRI‐2016), Horizontal Wind Model (HWM‐14), and Spectrometer Incoherent Scatter Model‐2,000 (NRLMSISE‐00). The EPB occurrence probability increased from 0% to 100% as increased from 0 to . Additionally, the occurrence probability exhibited seasonal variations, with a gradual increase during the equinox months, minimal occurrence during the June solstice, and a sudden increase during the December solstice. We found that the occurrence probability varied with day‐to‐day, season and solar activity for the same .
Value of portal venous gas and a nomogram for predicting severe neonatal necrotizing enterocolitis
Authors: Chen Yixian , Duan Yuhui , Wei Ba , Jiang Yongjiang , Tan Yadan , Wei Yijun , Gan Yuan , Chen Yujun 
Published: September 2024

Abstract

Background
Whether portal venous gas (PVG) is a sign of severe neonatal necrotizing enterocolitis (NEC) and predicts poor prognosis remains uncertain.

Methods
Patients from two centres were randomly assigned to a training set or a validation set. A nomogram model for predicting severe NEC was developed on the basis of the independent risk factors selected by least absolute shrinkage and selection operator (LASSO) regression analysis and multivariate logistic regression analysis. The model was evaluated based on the area under the curve (AUC), calibration curve, and decision curve analysis (DCA).

Results
A total of 585 patients met the study criteria, and propensity score matching resulted in 141 matched pairs for further analysis. Patients with PVG had a greater risk of surgical intervention or death compared with patients without PVG. A prediction model for severe NEC was established based on PVG, invasive mechanical ventilation (IMV), serum platelet count (PLT) and pH <7.35 at the onset of NEC. The model had a moderate predictive value with an AUC > 0.8. The calibration curve and DCA suggested that the nomogram model had good performance for clinical application.

Conclusion
A prediction nomogram model based on PVG and other risk factors can help physicians identify severe NEC early and develop reasonable treatment plans.

Impact

PVG is an important and common imaging manifestation of NEC.

Controversy exists regarding whether PVG is an indication for surgical intervention and predicts poor prognosis.

Our study suggested that patients with PVG had a greater risk of surgical intervention or death compared with patients without PVG.

PVG, IMV, PLT and pH <7.35 at the onset of NEC are independent risk factors for severe NEC.

A prediction nomogram model based on PVG and other risk factors may help physicians identify severe NEC early and develop reasonable treatment plans.
p21 Regulates Wnt-Notch balance via DREAM/MMB/Rb-E2F1 and maintains intestinal stem cell homeostasis
Authors: Jiang Liangxia , Tian Jie , Yang Jun , Luo Ronggang , Zhang Yongjin , Shao Chihao , Guo Bing , Wu Xiaoming , Dan Juhua , Luo Ying 
Published: September 2024

AbstractThe crosstalk and balance regulation of Wnt-Notch have been known to be essential for cell fate decision and tissue regeneration, however, how this balance is maintained and how the Wnt-Notch pathways are connected with cell cycle regulation is still not clear. By analyzing the molecular alterations in mouse model with accelerated aging phenotypes due to loss of p21 function in a Werner syndrome background, we observed that Wnt3 and β-Catenin were down-regulated, while Notch1 and Hes1 were up-regulated. This disruption in Wnt-Notch signaling was accompanied by the loss of intestinal stem cell compartment, increase in Bmi1 positive cells, loss of Olfm4/Lgr5 positive cells, and reduced secretory Paneth cells and goblet cells in the intestinal crypts of p21TKO mice. BrdU incorporation, cleaved caspase 3, and Tunel assay results revealed the fast turnover of intestinal epithelia, which may result in abnormal stem cell mobilization and exhaustion of the stem cell reservoir in the intestinal crypts. We further identified shift of DREAM complex towards MMB complex due to the loss of p21 as the cause for faster turnover of intestinal epithelia. Importantly, we identified the E2F1 as the transcriptional regulator for Notch1, which linked the p21-DREAM/MMB/Rb-E2F1 pathway with Wnt-Notch pathway. The overexpression of p21 rescued the DREAM pathway, as well as the imbalance of Wnt-Notch pathway. In summary, our data identify p21 as an important factor in maintaining sequential mobilization, proliferation, and homeostasis of intestinal stem cells.
Effectiveness of influenza vaccines in preventing acute cardiovascular events within 1 year in Beijing, China
Authors: Ma Yuan , Lu Feng , Suo Luodan , Li Wei , Qian Jie , Wang Tianqi , Lv Min , Wu Jiang , Yang Weizhong , Guo Moning , Li Juan , Feng Luzhao 
Published: September 2024

AbstractControversies persist about the protective effects of vaccines against acute cardiovascular events. Using electronic medical records from hospitals and influenza vaccine administration data in Beijing, China, we studied individuals vaccinated between January 1, 2016, and December 31, 2018, who experienced at least one acute cardiovascular event within two years. A self-controlled case series design calculated the relative incidence (RI) and 95% confidence interval (CI) of acute cardiovascular events within one year after vaccination. Among 1647 participants (median age: 65 years, 38.43% female), the risk of events 29–365 days post-vaccination was 0.76 times the baseline level (RI: 0.76; 95% CI: 0.68–0.84). The protective effect was more pronounced in younger participants (P = 0.043) and those without cardiovascular history (P < 0.001), while acute respiratory infection (P = 0.986) and vaccination frequency (P = 0.272) had no impact. Influenza vaccines offer protection against acute cardiovascular events for at least one year, suggesting potential for cardiovascular disease prevention.
Endemic, cosmopolitan, and generalist taxa and their habitat affinities within a coastal marine microbiome
Authors: James Chase C. , Allen Andrew E. , Lampe Robert H. , Rabines Ariel , Barton Andrew D. 
Published: September 2024

AbstractThe relative prevalence of endemic and cosmopolitan biogeographic ranges in marine microbes, and the factors that shape these patterns, are not well known. Using prokaryotic and eukaryotic amplicon sequence data spanning 445 near-surface samples in the Southern California Current region from 2014 to 2020, we quantified the proportion of taxa exhibiting endemic, cosmopolitan, and generalist distributions in this region. Using in-situ data on temperature, salinity, and nitrogen, we categorized oceanic habitats that were internally consistent but whose location varied over time. In this context, we defined cosmopolitan taxa as those that appeared in all regional habitats and endemics as taxa that only appeared in one habitat. Generalists were defined as taxa occupying more than one but not all habitats. We also quantified each taxon’s habitat affinity, defined as habitats where taxa were significantly more abundant than expected. Approximately 20% of taxa exhibited endemic ranges, while around 30% exhibited cosmopolitan ranges. Most microbial taxa (50.3%) were generalists. Many of these taxa had no habitat affinity (> 70%) and were relatively rare. Our results for this region show that, like terrestrial systems and for metazoans, cosmopolitan and endemic biogeographies are common, but with the addition of a large number of taxa that are rare and randomly distributed.
Antimicrobial gelatin-based films with cinnamaldehyde and ZnO nanoparticles for sustainable food packaging
Authors: Sultan Maha , Ibrahim Hassan , El-Masry Hossam Mohammed , Hassan Youssef R. 
Published: September 2024

AbstractCinnamaldehyde (CIN), a harmless bioactive chemical, is used in bio-based packaging films for its antibacterial and antioxidant properties. However, high amounts can change food flavor and odor. Thus, ZnO nanoparticles (NPs) as a supplementary antimicrobial agent are added to gelatin film with CIN. The CIN/ZnO interactions are the main topic of this investigation. FTIR-Attenuated Total Reflection (ATR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were utilized to investigate CIN/ZnO@gelatin films. Transmission electron microscope (TEM) images revealed nanospheres morphology of ZnO NPs, with particle sizes ranging from 12 to 22 nm. ZnO NPs integration increased the overall activation energy of CIN/ZnO@gelatin by 11.94%. The incorporation of ZnO NPs into the CIN@gelatin film significantly reduced water vapour permeability (WVP) of the CIN/ZnO@gelatin film by 12.07% and the oxygen permeability (OP) by 86.86%. The water sorption isotherms of CIN/ZnO@gelatin were described using Guggenheim-Anderson-de Boer (GAB) model. The incorporation of ZnO NPs into the CIN@gelatin film reduced monolayer moisture content (M0) by 35.79% and significantly decreased the solubility of CIN/ZnO@gelatin by 15.15%. The inclusion of ZnO into CIN@gelatin film significantly decreased tensile strength of CIN/ZnO@gelatin by 13.32% and Young`s modulus by 18.33% and enhanced elongation at break by 11.27%. The incorporation of ZnO NPs into the CIN@gelatin film caused a significant decrease of antioxidant activity of CIN/ZnO@gelatin film by 9.09%. The most susceptible organisms to the CIN/ZnO@gelatin film included Candida albicans, Helicobacter pylori, and Micrococcus leutus. The inhibition zone produced by the CIN/ZnO@gelatin film versus Micrococcus leutus was 25.0 mm, which was comparable to the inhibition zone created by antibacterial gentamicin (23.33 mm) and cell viability assessment revealed that ZnO/CIN@gelatin (96.8 ± 0.1%) showed great performance as potent biocompatible active packaging material.
Intelligent spectrophotometric resolution platforms for the challenging spectra of ipratropium and fenoterol in their combination inhaler with ecological friendliness assessment
Authors: Ali Salma N. , Saad Samah S. , Fayed Ahmed S. , Marzouk Hoda M. 
Published: September 2024

AbstractAsthma and chronic obstructive pulmonary disease (COPD) are the most common diagnoses for adults and children with respiratory tract inflammation. Recently, a novel fixed dose combination consisting of Ipratropium and Fenoterol has been released for the management and control of the symptoms of such disorders. The current research has newly developed and optimized three smart, accurate, simple, cost-effective, and eco-friendly spectrophotometric methods that enabled the simultaneous determination of the drugs under study in their combined inhaler dosage form, without the need for any previous separation steps, using water as a green solvent. The strategy employed was based on calculating one or two factors as a numerical spectrum or constant, which provided the complete removal of any component in the mixture that might overlap and the mathematical filtration of the targeted analyte. The methods developed could be classified into two types of spectrophotometric windows. Window I; involved absorption spectrum in their original zero-order forms (°D), which included recently designed methods named induced concentration subtraction (ICS) and induced dual wavelength (IDW). While window III focused on the ratio spectrum as the induced amplitude modulation (IAM) method. The extremely low absorptivity and lack of distinct absorption maximum in the zero-order absorption spectrum of Ipratropium were two intrinsic challenges that were better overcome by the proposed spectrophotometric methods than by the conventionally used ones. According to ICH guidelines, the proposed methods were validated using unified regression over range 2.0–40.0 µg/mL in the ICS method, while the linearity ranges for the IDW and IAM methods were 5.0–40.0 µg/mL of Ipratropium and 2.0–40.0 µg/mL of Fenoterol. Moreover, the three proposed methods were effectively used to assay the co-formulated marketed inhaler and further expanded to confirm the delivered dose uniformity in compliance with the USP guidelines. Finally, the established methods were evaluated for their greenness and blueness, in comparison to the official and reported analysis methods, using advanced cutting edge software metrics. Furthermore, the suggested techniques adhered well to the white analytical chemistry postulates that were recently published.
Analysis of fractionalized Brinkman flow in the presence of diffusion effect
Authors: Abbas Shajar , Ramzan Muhammad , Inam Inamullah , Saleem Salman , Nazar Mudassar , Abduvalieva Dilsora , AL Garalleh Hakim 
Published: September 2024

AbstractA vertical plate experiences a dynamic flow of fractionalized Brinkman fluid governed by fluctuating magnetic forces. This study considers heat absorption and diffusion-thermo effects. The novelty of model is the fractionalized Fourier’s and Fick’s laws. The problem is solved using the constant proportional Caputo derivative and Laplace transform method. The resulting non-dimensional equations for temperature, mass, and velocity fields are solved and compared visually. We explore the influence of various parameters like the fractional order, heat absorption/generation (Q), chemical reaction rate (R), and magnetic field strength (M) through informative graphs. Additionally, we contrast the velocity fields of fractionalized and regular fluids. The visualizations reveal that diffusion-thermo and mass Grashof number enhance fluid velocity, while chemical reaction and magnetic field tend to suppress it. For the interest of engineering, physical quantities such as Sherwood number, skin friction, and Nusselt number are computed. The present study satisfying all initial and boundary condition can be reduced to to previous published work which shows the validity of present work.
Predictive potential of distance-related spectral graphical descriptors for structure-property modeling of thermodynamic properties of polycyclic hydrocarbons with applications
Authors: Hayat Sakander , Alanazi Seham J. F. , Imran Muhammad , Azeem Muhammad 
Published: September 2024

AbstractA distance-related spectral descriptor is a graphical index with defining structure built on eigenvalues of chemical matrices relying on distances in graphs. This paper explores the predictive ability of both existing and new distance-related spectral descriptors for estimating thermodynamic characteristics of polycyclic hydrocarbons (PHs). As a standard choice, the entropy and heat capacity are selected to represent thermodynamic properties. Furthermore, 30 initial members of PHs are considered as test molecules for this study. Three new molecular matrices have been proposed and our research demonstrates that distance-spectral graphical indices built by these novel matrices surpass in efficiency relative to famous distance-spectral indices. First, a novel computational method is put forwarded to evaluate distance-spectral indices of molecular graphs. The proposed methodology is utilized to compute both pre-existing and novel distance-related spectral descriptors, with an aim to assess their predictive efficacy using experimental data pertaining to two selected thermodynamic properties. Subsequently, we identify the five most promising distance-related spectral descriptors, comprising the degree-distance and Harary energies, the recently introduced second geometric-arithmetic energy along with its associated Estrada invariant, and 2$$\text {nd}$$ atom-bond connectivity (ABC) Estrada index. Notably, the 2$$\text {nd}$$ ABC Estrada index and Harary energy demonstrate correlation coefficients exceeding 0.95, while certain conventional spectral indices including the distance energy as well as its associated Estrada index, display comparatively lower performance levels. Moreover, we illustrate the practical implications of our findings on specific classes of one-hexagonal nanocones and carbon polyhex nanotubes. These outcomes hold potential for enhancing the theoretical determination of certain thermodynamic attributes of these nanostructures, offering improved accuracy and minimal margin of error.
A randomized feasibility trial of time-restricted eating during pregnancy in people with increased risk of gestational diabetes
Authors: Skarstad Hanna M.S. , Haganes Kamilla L. , Sujan Md Abu Jafar , Gellein Trine M. , Johansen Mariell K. , Salvesen Kjell Å. , Hawley John A. , Moholdt Trine 
Published: September 2024

AbstractTime-restricted eating (TRE) is a nutritional intervention that confines the daily time-window for energy intake. TRE reduces fasting glucose concentrations in non-pregnant individuals, but whether this eating protocol is feasible and effective for glycemic control in pregnancy is unknown. The aim of this randomized controlled trial was to investigate the adherence to and effect of a 5-week TRE intervention (maximum 10 h daily eating window) among pregnant individuals at risk of gestational diabetes mellitus (GDM), compared with a usual-care control group. Participants underwent 2-h oral glucose tolerance tests and estimation of body composition, before and after the intervention. Interstitial glucose levels were continuously measured, and adherence rates and ratings of hunger were recorded daily. Thirty of 32 participants completed the trial. Participants allocated to TRE reduced their daily eating window from 12.3 (SD 1.3) to 9.9 (SD 1.0) h, but TRE did not affect glycemic measures, blood pressure, or body composition, compared with the control group. TRE increased hunger levels in the evening, but not in the morning, and induced only small changes in dietary intake. Adhering to a 5-week TRE intervention was feasible for pregnant individuals with increased risk of GDM but had no effect on cardiometabolic outcomes.
Brain gene expression reveals pathways underlying nocturnal migratory restlessness
Authors: Marasco Valeria , Fusani Leonida , Haubensak Patricia , Pola Gianni , Smith Steve 
Published: September 2024

AbstractMigration is one of the most extreme and energy demanding life history strategies to have evolved in the animal kingdom. In birds, champions of long-distance migrations, the seasonal emergence of the migratory phenotype is characterised by rapid physiological and metabolic remodelling, including substantial accumulation of fat stores and increases in nocturnality. The molecular underpinnings and brain adaptations to seasonal migrations remain poorly understood. Here, we exposed Common quails (Coturnix coturnix) to controlled changes in day length to simulate southward autumn migration, and then blocked the photoperiod until birds entered the non-migratory wintering phase. We first performed de novo RNA-Sequencing from selected brain samples (hypothalamus) collected from birds at a standardised time at night, either in a migratory state (when restlessness was highest and at their body mass peak), or in a non-migratory state and conducted differential gene expression and functional pathways analyses. We found that the migratory state was associated with up-regulation of a few, yet functionally well defined, gene expression networks implicated in fat trafficking, protein and carbohydrate metabolism. Further analyses that focused on candidate genes (apolipoprotein H or APOH, lysosomal associated membrane protein-2 or LAMP2) from samples collected during the day or night across the entire study population suggested differences in the expression of these genes depending on the time of the day with the largest expression levels being found in the migratory birds sampled at night. We also found that expression of APOH was positively associated with levels of nocturnal activity in the migratory birds; such an association was absent within the non-migratory birds. Our results provide novel experimental evidence revealing that hypothalamic changes in expression of apolipoprotein pathways, which regulate the circulatory transport of lipids, are likely key regulatory activators of nocturnal migratory movements. Our study paves the way for performing deeper functional investigations on seasonal molecular remodelling underlying the development of the migratory phenotype.