bluuebunny/crossref_metadata_2025_split huggingface dataset:
PV Power Output Control Improving Transient Stability of Power System with a Large Penetration of PV
Authors: MITSUGI YASUAKI , YOKOYAMA AKIHIKO , YAMADA SEIJI , TANIKAWA TOMOYA 
Published: November 2016

SUMMARYBecause of energy and environmental policies in the last decade, a lot of photovoltaic (PV) generations have been installed into power systems in Japan in recent years. In this situation, it is of great concern that disconnection of PV due to voltage drop caused by a system fault has a critical impact on power system stability. To avoid its disconnection, Fault Ride Through (FRT) requirement is applied for PVs. In this paper, PV power output control which improves transient stability of the power system with a huge amount of PVs is proposed and its effectiveness is confirmed by the numerical simulations.
SPH simulation of oblique shocks in compressible flows
Authors: Silla Matti , Bertola Volfango 
Published: November 2016

AbstractThe Lagrangian smoothed particle hydrodynamics (SPH) method is used to simulate shock waves in inviscid, supersonic (compressible) flow. It is shown for the first time that the fully Lagrangian SPH particle method, without auxiliary grid, can be used to simulate shock waves in compressible flow. The wall boundary condition is treated with ghost particles combined with a suitable repulsive potential function, whilst corners are treated by a novel ‘angle sweep’ technique. The method gives accurate predictions of the flow field and of the shock angle as compared with the analytical solution. The study shows that SPH is a good potential candidate to solve complex aerodynamic problems, including those involving rarefied flows, such as atmospheric re‐entry. Copyright © 2016 John Wiley & Sons, Ltd.
Enhancing capillary trapping effectiveness through proper time scheduling of injection of supercritical CO2 in heterogeneous formations
Authors: González‐Nicolás Ana , Trevisan Luca , Illangasekare Tissa H. , Cihan Abdullah , Birkholzer Jens T. 
Published: November 2016

AbstractThe impact of geologic heterogeneity on capillary trapping of supercritical CO2 (scCO2) has been recognized and appraised through laboratory experimentation and modeling. However, how different injection strategies can be optimized to improve capillary trapping has not received adequate attention. We present a study based on stochastic analysis to show the impact of injection scheduling on capillary trapping of scCO2 in heterogeneous geological formations. Improvement of trapping efficiency consists of maximizing the trapped volume within a predefined secure zone of the storage formation with the goal of avoiding plume intersection with potential leakage pathways. Using knowledge acquired from physical experiments in intermediate‐scale tanks with controlled heterogeneity, we conduct numerical simulations following a stochastic approach to extend the observed outcomes to a series of equally probable permeability scenarios. Our simulations involve the same combination of surrogate fluids that are used in the experiments to mimic viscosity and density contrasts between scCO2 and brine. To account for uncertainty of formation heterogeneity, several permeability fields with three different variances and two horizontal correlation lengths are generated. The same volume of scCO2 is emplaced using four different modes of injection scheduling. Results suggest that injection strategies aimed at enhancing capillary trapping of scCO2 and increasing the probability of constraining the plume within a secure zone are strictly related to the specific heterogeneity of the reservoir. This preliminary theoretical finding suggests the potential for maximizing secure capillary trapping through the proper selection of injection schedule to fit the formation heterogeneity. © 2016 Society of Chemical Industry and John Wiley & Sons, Ltd.
Osseointegrated implants into a variety of composite free flaps: A comparative analysis
Authors: Burgess Michael , Leung Matthew , Chellapah Anthony , Clark Jonathan R. , Batstone Martin D. 
Published: November 2016

AbstractBackgroundSignificant oral function is often lost after surgical therapy for head and neck cancer. The use of osseointegrated implants for reconstruction in patients with head and neck surgery has shown to significantly improve the quality of life for these patients. Variable success rates range from 99% to 70%.MethodsA retrospective audit of patient records was performed looking at cumulative survival of implants. Inclusion criteria were patients who were treated at 1 of 2 designated Australian Head and Neck Units and received oral osseointegrated implants.ResultsFifty‐nine patients were included for analysis. One hundred ninety‐nine implants were placed into vascularized bone grafts (VBGs). There were 11 implant failures with an overall success rate of 94.5%. There was 1 significant adverse outcome with a pathological fracture of a flap after implant placement. Implant success in scapula and iliac crest flaps was comparable to fibula flaps.ConclusionImplants placed into VBGs have a reasonable success rate in well‐selected patients. © 2016 Wiley Periodicals, Inc. Head Neck 39: 443–447, 2017
Neurite extension and neuronal differentiation of human induced pluripotent stem cell derived neural stem cells on polyethylene glycol hydrogels containing a continuous Young's Modulus gradient
Authors: Mosley Matthew C. , Lim Hyun Ju , Chen Jing , Yang Yueh‐Hsun , Li Shenglan , Liu Ying , Smith Callahan Laura A. 
Published: November 2016

AbstractMechanotransduction in neural cells involves multiple signaling pathways that are not fully understood. Differences in lineage and maturation state are suggested causes for conflicting reports on neural cell mechanosensitivity. To optimize matrices for use in stem cell therapy treatments transplanting human induced pluripotent stem cell derived neural stem cells (hNSC) into lesions after spinal cord injury, the effects of Young's Modulus changes on hNSC behavior must be understood. The present study utilizes polyethylene glycol hydrogels containing a continuous gradient in Young's modulus to examine changes in the Young's Modulus of the culture substrate on hNSC neurite extension and neural differentiation. Changes in the Young's Modulus of the polyethylene glycol hydrogels was found to affect neurite extension and cellular organization on the matrices. hNSC cultured on 907 Pa hydrogels were found to extend longer neurites than hNSC cultured on other tested Young's Moduli hydrogels. The gene expression of β tubulin III and microtubule‐associated protein 2 in hNSC was affected by changes in the Young's Modulus of the hydrogel. The combinatory method approach used in the present study demonstrates that hNSC are mechanosensitive and the matrix Young's Modulus should be a design consideration for hNSC transplant applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 824–833, 2017.
List‐Coloring the Squares of Planar Graphs without 4‐Cycles and 5‐Cycles
Authors: Cranston Daniel W. , Jaeger Bobby 
Published: November 2016

AbstractLet G be a planar graph without 4‐cycles and 5‐cycles and with maximum degree . We prove that . For arbitrarily large maximum degree Δ, there exist planar graphs of girth 6 with . Thus, our bound is within 1 of being optimal. Further, our bound comes from coloring greedily in a good order, so the bound immediately extends to online list‐coloring. In addition, we prove bounds for ‐labeling. Specifically, and, more generally, , for positive integers p and q with . Again, these bounds come from a greedy coloring, so they immediately extend to the list‐coloring and online list‐coloring variants of this problem.
Risk factors for latent distant organ metastasis detected by staging laparoscopy in patients with radiologically defined locally advanced pancreatic ductal adenocarcinoma
Authors: Karabicak Ilhan , Satoi Sohei , Yanagimoto Hiroaki , Yamamoto Tomohisa , Hirooka Satoshi , Yamaki So , Kosaka Hisashi , Inoue Kentaro , Matsui Yoichi , Kon Masanori 
Published: November 2016

AbstractObjectivesWe aimed to identify risk factors for latent distant organ metastasis in patients with radiographically defined locally advanced (RDLA) pancreatic ductal adenocarcinoma (PDAC).MethodsRDLA disease was defined as unresectable disease without distant organ metastasis based on resectability status by NCCN guidelines. Between January 2005 and November 2015, 110 consecutive patients underwent staging laparoscopy to rule out latent distant metastasis. Univariate and multivariate analyses were performed to identify risk factors for latent distant organ metastasis or peritoneal metastasis (PM), defined as peritoneal dissemination and/or positive peritoneal lavage cytology (PPC).ResultsLatent distant organ metastasis was diagnosed by staging laparoscopy in 62 patients. PPC was found in 23%, peritoneal dissemination in 19%, and liver metastasis in 15%. Univariate analysis showed tumor location, preoperative CA 19‐9 level and tumor size, and multivariate analysis revealed tumor size >55 mm and CA 19‐9 level >60 IU/ml as risk factors for latent distant metastasis. Multivariate analysis showed pancreas body‐tail tumors and tumor size >42 mm as risk factors for PM; 65.4% of pancreas body‐tail tumors >42 mm had PM.ConclusionsPatients with large pancreas body‐tail tumors and high CA 19‐9 level are at greater risk for latent distant organ metastasis or PM, and should undergo staging laparoscopy routinely for accurate diagnosis (UMIN000023125).
Abnormal baseline brain activity in Parkinson's disease with and without REM sleep behavior disorder: A resting‐state functional MRI study
Authors: Li Dan , Huang Peiyu , Zang Yufeng , Lou Yuting , Cen Zhidong , Gu Quanquan , Xuan Min , Xie Fei , Ouyang Zhiyuan , Wang Bo , Zhang Minming , Luo Wei 
Published: November 2016

PurposeTo investigate the differences in spontaneous brain activity between Parkinson's disease (PD) patients with rapid eye movement sleep behavior disorder (RBD), PD patients without RBD, and normal controls, which may shed new light on the neural mechanism of RBD.Materials and MethodsEighteen PD patients with RBD, 16 patients without RBD, and 19 age‐ and gender‐matched normal controls underwent clinical assessment and functional magnetic resonance imaging (fMRI) with a 3.0T scanner. Resting‐state fMRI scans were collected using an echo planar imaging sequence. Amplitude of low‐frequency fluctuations (ALFF) were calculated to measure spontaneous brain activity in each subject.ResultsCompared with PD patients without RBD, patients with RBD exhibited significantly decreased ALFF values (P < 0.001, cluster level) in primary motor cortex extending to premotor cortex. Compared with normal controls, PD patients exhibited decreased ALFF values (P < 0.001, cluster level) in caudate and putamen (P < 0.001, cluster level), and increased ALFF values (P = 0.03, cluster level) in prefrontal cortex.ConclusionThe altered spontaneous brain activity in motor cortex may contribute to the pathogenesis of RBD in PD patients, which further supports the idea that the pathophysiology of RBD involves not only midbrain dysfunction but also cerebral cortex abnormalities. Our findings provide additional insight into the neural mechanism of RBD and may drive future research to develop better treatment.Level of Evidence: 3Technical Efficacy: Stage 3J. MAGN. RESON. IMAGING 2017;46:697–703
Liver transplantation for fibrolamellar hepatocellular carcinoma: A national perspective
Authors: Atienza Leonardo Garcia , Berger Jonathan , Mei Xiaonan , Shah Malay B. , Daily Michael F. , Grigorian Alla , Gedaly Roberto 
Published: November 2016

BackgroundFibrolamellar Hepatocellular Carcinoma (FL‐HCC) is a rare primary liver tumor that usually presents in younger patients without underlying liver disease.MethodsWe queried the United Network of Organ Sharing (UNOS) database between October 1988 and January 2013 to evaluate outcomes in patients with FL‐HCC undergoing liver transplantation in the United States compared to patients with conventional Hepatocellular Carcinoma (HCC).ResultsSixty‐three patients were identified (57% female, mean age 30 years). Only one patient (2%) had an associated Hepatitis C Virus. Mean Model for End‐Stage Liver Disease (MELD) score at the time of transplantation was 11.3. Mean waiting time was 325 days and mean cold ischemic time was 6 hr. Overall survival of FL‐HCC patients at 1, 3, and 5 years was 96%, 80%, and 48% as compared to HCC patients whose rates were 89%, 77%, and 68%. Six patients had tumor recurrence (10%). The Cox Model demonstrated that MELD and cold ischemic time are the strongest predictors of overall survival in FL‐HCC patients. Age and wait time were not associated with poor patient survival in this series.ConclusionsGood results can be obtained in selected patients transplanted for FL‐HCC. FL‐HCC patients had similar survival compared to those transplanted for HCC. J. Surg. Oncol. 2017;115:319–323. © 2016 Wiley Periodicals, Inc.
CLN8 disease caused by large genomic deletions
Authors: Beesley Clare , Guerreiro Rita J. , Bras Jose T. , Williams Ruth E. , Taratuto Ana Lia , Eltze Christin , Mole Sara E. 
Published: November 2016

AbstractBackgroundThe presence of deletions can complicate genetic diagnosis of autosomal recessive disease.MethodThe DNA of patients was analyzed in a diagnostic setting.ResultsWe present three unrelated patients each carrying deletions that encompass the 37 kb CLN8 gene and discuss their phenotype. Two of the cases were hemizygous for a mutant allele – their deletions unmasked a mutation in CLN8 on the other chromosome.ConclusionMicroarray analysis is recommended in any patient suspected of NCL who is apparently homozygous for a mutation that is not present in one of the parents or when the family has no known consanguinity.
Comparison of the outcomes of free jejunal flap reconstructions of pharyngoesophageal defects in hypopharyngeal cancer and corrosive injury patients
Authors: Hsieh Mu‐Han , Yang Yun‐Tai , Tsai Yueh‐Ju , Kuo Yur‐Ren , Lin Pao‐Yuan 
Published: November 2016

IntroductionFree jejunal flap is one of the optimal choices for restoring upper digestive tract. The purpose of this study was to introduce the treatment strategies and to compare the outcomes of free jejunal flap for pharyngoesophageal reconstruction between hypopharyngeal cancer and chemical corrosive injured esophagus.MethodsFrom 2001 to 2012, patients who had been received esophageal reconstruction by free jejunal flap for pharyngoesophageal defect were divided into squamous cell carcinoma (SCC) group and corrosive chemical injury (CCI) group. All data on outcomes and complications including relevant radiographic investigations were collected retrospectively.ResultsSixteen patients were in SCC group and 9 patients in CCI group underwent free jejunal flap reconstruction. Two cases of flap failure were noted in SCC group, and no flap failure in CCI group—the total failure rate was 8% (2/25 patients). In SCC group, 5 of 16 patients (31.3%) developed fistula; however, no fistula in CCI group. One patient in SCC group and 3 patients in CCI group developed esophageal strictures. Other than early stricture (stricture <1 year) which reached significant difference, all of other complications were not statistically significant between two groups. The average follow‐up time was 42 months.ConclusionsPostoperative early stricture but lower fistula occurrence is expected in patients with corrosively injured esophagi. This helpful preliminary findings could not only early‐check complication, but also better explanation and prepare were taken placed before operation.
Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight‐obese individuals consuming pomegranate: A randomized clinical trial
Authors: González‐Sarrías Antonio , García‐Villalba Rocío , Romo‐Vaquero María , Alasalvar Cesarettin , Örem Asim , Zafrilla Pilar , Tomás‐Barberán Francisco A. , Selma María V. , Espín Juan Carlos 
Published: November 2016

ScopeThe pomegranate lipid‐lowering properties remain controversial, probably due to the interindividual variability in polyphenol (ellagitannins) metabolism.ObjectiveWe aimed at investigating whether the microbially derived ellagitannin‐metabolizing phenotypes, i.e. urolithin metabotypes A, (UM‐A), B (UM‐B), and 0 (UM‐0), influence the effects of pomegranate extract (PE) consumption on 18 cardiovascular risk biomarkers in healthy overweight‐obese individuals.Methods and resultsA double‐blind, crossover, dose–response, randomized, placebo‐controlled trial was conducted. The study (POMEcardio) consisted of two test phases (dose‐1 and dose‐2, lasting 3 weeks each) and a 3‐week washout period between each phase. Forty‐nine participants (BMI > 27 kg/m2) daily consumed one (dose‐1, 160 mg phenolics/day) or four (dose‐2, 640 mg phenolics/day) PE or placebo capsules. Notably, UM‐B individuals showed the highest baseline cardiovascular risk. After dose‐2, total cholesterol (–15.5 ± 3.7%), LDL‐cholesterol (–14.9 ± 2.1%), small LDL‐cholesterol (–47 ± 7%), non‐HDL‐cholesterol (–11.3 ± 2.5%), apolipoprotein‐B (–12 ± 2.2%), and oxidized LDL‐cholesterol –24 ± 2.5%) dose dependently decreased (P < 0.05) but only in UM‐B subjects. These effects were partially correlated with urolithin production and the increase in Gordonibacter levels. Three (50%) nonproducers (UM‐0) became producers following PE consumption.ConclusionsUM clustering suggests a personalized effect of ellagitannin‐containing foods and could explain the controversial pomegranate benefits. Research on the specific role of urolithins and the microbiota associated with each UM is warranted.
Translocation of Tektin 3 to the equatorial segment of heads in bull spermatozoa exposed to dibutyryl cAMP and calyculin A
Authors: Tsukamoto Mariko , Hiyama Erina , Hirotani Karen , Gotoh Takafumi , Inai Tetsuichiro , Iida Hiroshi 
Published: November 2016

SUMMARYTektins (TEKTs) are filamentous proteins associated with microtubules in cilia, flagella, basal bodies, and centrioles. Five TEKTs (TEKT1, ‐2, ‐3, ‐4, and ‐5) have been identified as components of mammalian sperm flagella. We previously reported that TKET1 and ‐3 are also present in the heads of rodent spermatozoa. The present study clearly demonstrates that TEKT2 is present at the acrosome cap whereas TEKT3 resides just beneath the plasma membrane of the post‐acrosomal region of sperm heads in unactivated bull spermatozoa, and builds on the distributional differences of TEKT1, ‐2, and ‐3 on sperm heads. We also discovered that hyperactivation of bull spermatozoa by cell‐permeable cAMP and calyculin A, a protein phosphatase inhibitor, promoted translocation of TEKT3 from the post‐acrosomal region to the equatorial segment in sperm heads, and that TEKT3 accumulated at the equatorial segment is lost upon acrosome reaction. Thus, translocation of TEKT3 to the equatorial segment may be a capacitation‐ or hyperactivation‐associated phenomenon in bull spermatozoa. Mol. Reprod. Dev. 84: 30–43, 2017. © 2016 Wiley Periodicals, Inc.
Rapid Naked‐Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non‐Crosslinking Aggregation of DNA‐Functionalized Gold Nanoparticles
Authors: Akiyama Yoshitsugu , Wang Guoqing , Shiraishi Shota , Kanayama Naoki , Takarada Tohru , Maeda Mizuo 
Published: November 2016

AbstractInvolvement of single‐nucleotide polymorphism (SNP) genotyping in healthcare should allow for more effective use of pharmacogenomics. However, user‐friendly assays without the requirement of a special instrument still remain unavailable. This study describes naked‐eye SNP discrimination in exon 5 of the human cytochrome P450 2C19 monooxygenase gene, CYP2C19*1 (the wild‐type allele) and CYP2C19*2 (the variant allele with G681A point mutation). The present assay is composed of allele‐specific single‐base primer extension and salt‐induced aggregation of DNA‐modified gold nanoparticles (DNA–AuNPs). Genetic samples extracted from human hair roots are subjected to this assay. The results are verified by direct sequencing. This study should promise the prospective use of DNA–AuNPs in gene diagnosis.
Risk‐adapted stratification for optimally intensive treatment assignment of pediatric patients with non‐Hodgkin lymphoma is an effective strategy in developing countries
Authors: Belgaumi Asim F. , Anas Mohammed , Siddiqui Khawar S. , Akhter Mohammed F. , Al‐Kofide Amani 
Published: November 2016

AbstractBackgroundPediatric patients with non‐Hodgkin lymphoma (NHL) in developing countries (DCs) present with greater tumor load even at lower stages and with comorbidities that impact therapy delivery. This causes toxic mortality with “standard” intensive protocols or recurrences with “gentler” treatment.ObjectivesWe developed and evaluated a risk stratification schema that guides intensity of therapy.Design/MethodsSixty‐nine patients were prospectively assigned to five risk groups (A–E; n = 6, 15, 16, 15, and 17) following staging and treated with protocols of risk‐stratified intensity. Risk stratification utilized St. Jude stage, disease bulk, and sites involved.ResultsBetween 2006 and 2011, 69 patients with B‐cell NHL were enrolled. Among these, 72.5% were boys with mean age of 6.9 years (±3.33 [SD]; range 2.4–14.2 years). Eighty‐seven percent had Burkitt lymphoma, 82.6% had advanced stage (25 [36.2%] stage III; 32 [46.4%] stage IV), and 24.6% were central nervous system positive. Mean lactate dehydrogenase increased progressively across the risk strata. Among these, 0/6, 1/15, 3/16, 2/15, and 7/17 patients relapsed/progressed within each risk stratum. Fifteen patients died; three from treatment‐related toxicity. At a median follow‐up of 6.2 years, the overall and event‐free survival (EFS) for all patients was 78.1 and 75.4%, respectively; EFS was related to risk assignment. The frequency of documented infectious and noninfectious toxicities increased with higher risk group assignment causing prolongation of admissions and potential treatment delays.ConclusionsReduction in treatment intensity for an identified subset of patients with NHL is feasible, while high‐intensity therapy is required for high‐risk groups. This risk stratification system may be a first step toward improving the outcomes in some DCs.