bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct Features of Tropical Cyclone Landfall over East Asia during Various Types of El Niño
Authors: Pan Lixia , Wang Xin , Chen Jiepeng , Zhan Haigang 
Published: September 2024

Abstract
Numerous studies focus on the impacts of ENSO diversity on tropical cyclone (TC) activities in the western North Pacific (WNP). In recent years, there is a growing threat of landfalling and northward-moving TCs in East Asia, accompanying an increase in central Pacific (CP) El Niño. Here, we aim to discover variations in landfalling TCs during various types of CP El Niño (CP-I and CP-II El Niño). It is found that significant changes in landfalling and going northward TCs over East Asia north 20°N are modulated by CP-I El Niño. During CP-I El Niño, TCs tend to landfall more often over the mainland of China with longer duration, moving distance, and stronger power dissipation index (PDI) after landfall and increased TC-induced rainfall, due to favorable conditions (beneficial steering flow, weak vertical wind shear, increased specific humidity, increased soil moisture, and temperature), especially significant over the northeastern part. The situation over the mainland of China is reversed during eastern Pacific (EP) El Niño and CP-II El Niño, with a significant decrease in the characteristics with corresponding unfavorable environments. Over the Korean Peninsula and Japan, the frequency of TC landfalls, as well as the duration and the moving distance after landfall, exhibits greater levels during CP-I and CP-II El Niño than during EP El Niño due to favorable steering flow, and thus, TC-induced rainfall enhances correspondingly. Regarding the PDI over the Korean Peninsula and Japan, it remains relatively consistent across all El Niño types. However, a notable increase in the PDI during EP El Niño could be attributed to the higher intensity of TCs prior to landfall.
Determination of mechanical and tribological properties of vacuum sintered hybrid reinforced Al-4Cu composites
Authors: Usca Üsame Ali , Şap Serhat , Uzun Mahir , Değirmenci Ünal 
Published: September 2024

This study aims to modernize commonly preferred hybrid aluminum composites in the automotive and defense industries. For this purpose, Al-4Cu/B4C-SiC hybrid composites were manufactured using the hot pressing method and their microstructure, mechanical, and tribological properties were investigated. SEM/EDS analyses of the samples were conducted to examine morphological characteristics. Hardness, relative density, and three-point bending tests were performed on the produced samples. Additionally, wear tests were conducted under dry sliding conditions and different loads (5-10-15 N) to investigate tribological properties. The addition of hybrid reinforcements resulted in high hardness (88.54 HB) and relative density (98.83%) values. The highest bending stress (556.9 MPa) was observed in sample AC-4 (Al-4Cu/2B4C-2SiC). The lowest mass loss (1.1 × 10−3 g) was encountered in sample AC-6 (Al-4Cu/6B4C-6SiC), where all reinforcements were present together. Plastic deformation, oxidation, and residual wear mechanisms were identified on the worn surfaces of the samples. Consequently, the addition of hybrid reinforcements to Al-4Cu composites shows promising potential in enhancing the mechanical and tribological performance of the composites.
Introducing simulation-based education to Genitourinary Medicine specialty training in the North West of England: A quality improvement project exploring trainee perspectives and impact
Authors: Ezeh Izuchukwu Williams 
Published: September 2024

Introduction Simulation-based education (SBE) provides enactive experiences for learners. This project explores the utility of SBE in GUM training. Methods Phase 1 was a qualitative survey of GUM trainees across the UK exploring their views on SBE. Phase 2 involved roll-out of SBE to new GUM trainees. Feedback was subsequently obtained. Results Twenty-three participants were surveyed in phase 1. When asked to rate the relevance of SBE to curriculum competencies on a scale of 1 to 5 (1 = not relevant, 5 = highly relevant), the highest ratings (score ≥4) were for proctoscopy (4.1), IUD insertion (4.1), SDI removal (4.1), SDI insertion (4.0), and punch biopsy (4.0). All curriculum items scored ≥3. Eighty-three percent ( n = 19) felt SBE will improve clinician confidence and competence. Following introduction of SBE, participants fed back on the relevance of the session. All 5 respondents rated the session ≥4 for addressing their clinical and curriculum goals. All respondents rated the session ≥4 for improving clinician confidence and competence. The session received an overall rating of 5, and respondents similarly rated 5 for more sessions. Conclusion Trainees recognise the value of simulated learning experiences and its role in improving procedural competence and addressing bespoke human factor skills relevant to GUM.
Determination of Four Compositions of Lonicerae japonicae flos Based on UPLC–MS/MS Method
Authors: Ran Xie , Feng Liu , Hongying Fang , Yuguo Xu , Honglian Zhang 
Published: September 2024

Background Lonicerae japonicae flos, a representative kind of Traditional Chinese Medicine (TCM) for clearing heat and detoxifying, is known as Jinyinhua in China. The determination of multiple components’ content, especially multiple pharmacological components’ content, is often used to evaluate the quality of TCM, which could objectively evaluate the quality of TCM. Objectives The ultra high-performance liquid chromatography–mass spectrometry/mass spectrometry (UPLC–MS/MS) method was used to determine the content of chlorogenic acid, isochlorogenic acid A, isochlorogenic acid C, and luteoloside in the current study. Materials and Methods 15 batches of Lonicera japonica flos were collected from different sources. 75% methanol was taken as a solvent, and the solution ratio was 1 (mg:mL). The ultrasonic method was utilized to prepare the sample solution for 30 min, which was centrifuged for 10 min at 10,000 rpm. Then, the supernatant was taken for reserve. C18 was chosen as the fixed phase, and acetonitrile (A)–0.1% phosphate acid solution (B) was chosen as the mobile phase. The flow rate was 0.3 mL.min−1. The column temperature was 40°C, and the sample injection was 1 µL. In the negative ion mode, data were collected using multiple reaction monitoring (MRM) scan mode. Results The scope of chlorogenic acid, isochlorogenic acid A, isochlorogenic acid C, and luteoloside was in the range of 62.5–6,250 ng. mL−1, which had good linearity ( r2 = 0.9997). The content of the four components showed some differences among different sources. Conclusion The method was fast and sensitive, which could effectively evaluate and control the quality of Lonicera japonica flos.
Safe Infant Sleep Practices and Associated Factors Among Mothers Attending Vaccination Service at Dessie Town Governmental Health Care Facilities, 2021
Authors: Goshiye Debrnesh , Gedamu Sisay 
Published: September 2024

Background: Babies spend a lot of their time with sleeping thus they need to have a safe sleep. Inadequate sleeping arrangements might heighten the likelihood of Sudden Unexpected mortality in Infancy (SUDI), including SIDS and lethal sleeping mishaps, which continue to be the most prevalent cause of mortality for individuals aged 1 to 1 year. Objective: The study aimed to assess safe baby sleep practices and associated factors among women receiving immunizations at government healthcare facilities in Dessie Town. Design: An institution-based cross-sectional study Methods: We conducted interviews with a total of 392 mothers using semi-structured questionnaires at public health facilities of Dessie town, in 2021. After the data were entered into the EPI data version 3.1, SPSS 23 was utilized for the analysis. Additionally, multivariate and binary logistic regression analyses were carried out. In multivariate analysis, a P-value less than .05 indicate a significant association. Results: About 38.3%, 21.9%, and 14.7% had safe infant sleep practice regarding sleep position, no soft-bedding and sleep arrangement respectively. Significant association was observed between safe infant sleep position with baby age less than 3 months (AOR = 2.96, 95% CI = 1.50-5.84), baby age of 7 to 9 months (AOR = 3.84, 95% CI = 2.15-6.85), maternal level of education(AOR = 4.48, 95% CI = 1.87-10.76), relative/friend as their source of information (AOR = 1.98, 95% CI = 1.14-3.44), grandmother as their source of information (AOR = 1.89, 95% CI = 1.00-3.57).Additionally, baby age 4 to 6 months (AOR = 0.93, 95% CI = 0.19-0.94) and maternal level of education (AOR = 0.19, 95% CI = 0.04-0.92) shows a significant safe infant bed arrangement practice. Furthermore, baby age of 10 to 12 months (AOR = 0.49, 95% CI = 0.25-0.98) and maternal education level of college and above (AOR = 3.44, 95% CI = 1.18-10.03) also shows significant association with safe soft-bedding practice. Conclusion: Mothers’ safe infant sleep practices were found to be low in Dessie town. Therefore, efforts should be made to enhance mothers’ attentiveness and engagement. This will help them follow healthy infant sleep practices.
Mitochondrial dsRNA from B-ALL cells stimulates mesenchymal stromal cells to become cancer-associated fibroblasts
Authors: Burt Richard J. , Dey Aditi , Akarca Ayse , Allen Hermione , Amerikanou Rodothea , Atkinson Samantha , Auty David , Chatzigerou Jenny , Cutler Emily , Guerra-Assuncao Jose Afonso , Kirschner Kristina , Kumari Ruchi , Manji Jiten , Marafioti Teresa , Ward Juma , Fielding Adele K. 
Published: September 2024

Abstract
Cancer-associated fibroblasts (CAFs) arising from bone marrow–derived mesenchymal stromal cells (MSCs) are prominent in B-cell precursor acute lymphoblastic leukemia (B-ALL). We have previously shown that CAF formation is triggered by exposure to reactive oxygen species–inducing chemotherapy and that CAFs support chemoresistance by donating mitochondria to the cancer cells through tunneling nanotubes. In the present study, we show that exposure of MSCs to ALL cell lines, patient-derived xenografts, and primary cells or their conditioned media can also trigger CAF formation. Using bulk RNA sequencing in cell lines, we show that the MSC to CAF transition is accompanied by a robust interferon pathway response, and we have validated this finding in primary cells. Using confocal microscopy and flow cytometry, we identify the uptake of leukemia cell–derived mitochondrial double-stranded RNA (dsRNA) by MSCs as a proximate trigger for the MSC to CAF transition. We demonstrate that inhibiting dsRNA formation in ALL cells by treatment with low-dose ethidium bromide or the mitochondrial transcription inhibitor IMT1, or degrading dsRNA in conditioned media by 100°C exposure eliminates the ability of the ALL conditioned media to stimulate MSC to CAF transition. Our data reveal, to our knowledge, a novel and previously undescribed mechanism by which cancer cells induce a CAF phenotype in stromal cells, showing how B-ALL cells can directly induce the previously described niche-mediated protection within the bone marrow.
Liver-related aspects of valoctocogene roxaparvovec gene therapy for hemophilia A: expert guidance for clinical practice
Authors: La Mura Vincenzo , Cardinale Vincenzo , De Cristofaro Raimondo , De Santis Adriano , Di Minno Giovanni , Fabris Luca , Marra Fabio , Morisco Filomena , Peyvandi Flora , Pompili Maurizio , Santoro Cristina , Zanon Ezio , Castaman Giancarlo 
Published: September 2024

Abstract
Adeno-associated virus–based gene therapy (valoctocogene roxaparvovec) is an attractive treatment for hemophilia A. Careful clinical management is required to minimize the risk of hepatotoxicity, including assessment of baseline liver condition to determine treatment eligibility and monitoring liver function after gene therapy. This article describes recommendations (developed by a group of hemophilia experts) on hepatic function monitoring before and after gene therapy. To prevent harmful liver-related effects, gene therapy is contraindicated in patients with uncontrolled liver infections, autoimmune hepatitis, liver stiffness ≥8 kPa, or cirrhosis. Before using gene therapy in patients with liver steatosis or other liver disorders, the risk of liver damage should be considered using a highly individualized approach. Treatment is not recommended in patients with abnormal liver enzymes, including alanine aminotransferase (ALT) at any level above the upper limit of normal (ULN). Therefore, pretreatment assessment of liver health should include laboratory tests, abdominal ultrasound, and liver stiffness measurements by transient elastography (TE). In the first year after therapy, ALT levels should be monitored 1 to 2 times per week to detect elevations ≥1.5× ULN, which may require immunosuppressant therapy. Patients with ALT elevation should receive prednisone 60 mg/d for 2 weeks, followed by stepwise tapering when ALT returns to baseline. ALT monitoring should continue long term (every 3-6 months), along with abdominal ultrasound (every 6 months) and TE (yearly) evaluations. When patients with good liver health are selected for treatment and closely monitored thereafter, ALT elevations can be promptly treated and are expected to resolve without long-term hepatic sequelae.
Acute and preventive treatment of menstrual migraine: a meta-analysis
Authors: Khoo Cindy Ciat-Wuah , Liu Chan-Cheng , Lu Michael , Huang Yu-Chen , Weng Hsing-Yu 
Published: September 2024

Abstract
Background and objectives
About a quarter of migraine cases among women have menstrual migraine (MM), which is usually more severe, longer lasting, and less responsive to treatment than typical migraine. Randomized controlled trials (RCTs) have evaluated the efficacy of several medication in the acute and preventive treatment of MM; this meta-analysis compared the effectiveness of these treatments.

Methods
We conducted systematic searches in the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase databases. The primary outcomes of acute treatment trials were pain relief at 2 and 24 h after treatment compared with placebo or another treatment. The three endpoints we checked for studying MM prevention were: no recurrence of headaches each month, a 50% reduction in monthly migraine days from baseline, and a decrease in the mean number of headache days per month.

Results
Out of 342 studies, 26 RCTs met the criteria. Triptans, combined with or without other analgesics, were superior to placebo in providing pain relief in the acute treatment and prevention of MM. Among the treatments, sumatriptan and lasmiditan demonstrated superior pain relief at 2 h (OR: 4.62) and 24 h (OR: 4.81). Frovatriptan exhibited effectiveness in preventing headache recurrence, whereas galcanezumab and erenumab displayed significant preventive benefits in reducing headache days per month.

Conclusion
Sumatriptan and lasmiditan are effective first-line treatments for acute MM. For prevention, frovatriptan may be the more effective of triptans. Compared with triptans, CGRP monoclonal antibodies, here including erenumab and galcanezumab, are more effective in reducing headache days, and therefore, in preventing MM.
Experiences of patients with advanced chronic diseases and their associates with a structured palliative care nurse visit followed by an interprofessional case conference in primary care – a deductive-inductive content analysis based on qualitative interviews (KOPAL-Study)
Authors: Pohontsch Nadine Janis , Weber Jan , Stiel Stephanie , Schade Franziska , Nauck Friedemann , Timm Janina , Scherer Martin , Marx Gabriella 
Published: September 2024

Abstract
Background
Chronic, non-malignant diseases (CNMD) like chronic obstructive pulmonary disease (COPD), congestive heart failure (CHF) and dementia in advanced stages are very burdensome for patients. Timely palliative care with strong collaboration between general practitioners (GPs) and specialist palliative home care (SPHC) teams can reduce symptom burden, hospitalization rates, hospitalization costs and overall healthcare costs. The KOPAL-study on strengthening interprofessional collaboration for patients with palliative care needs tested the effect of an intervention comprising of a SPHC nurse assessment and an interprofessional case conference. This qualitative evaluative study explores patients’, proxies’ and their associates’ motivation to participate in the KOPAL-study and views on the (benefits of the) intervention.

Methods
We interviewed 13 male and 10 female patients as well as 14 proxies of patients with dementia and six associates of study participants using a semi-structured interview guide. All interviews were digitally recorded, transcribed verbatim and analysed with deductive-inductive qualitative content analysis.

Results
Motivation for participation was driven by curiosity, the aim to please the GP or to support research, respectively to help other patients. Few interviewees pointed out to have expected positive effects for themselves. The nurse visit was evaluated very positively. Positive changes concerning health care or quality of life were reported sparsely. Most study participants did not prepare for the SPHC nurse assessment. They had no expectations concerning potential benefits of such an assessment, the interdisciplinary case conference and an early integration of palliative care. The majority of interviewees reported that they did not talk about the nurse visit and the interprofessional case conference with their GPs.

Conclusion
Our results lead to the conclusion that SPHC nurses can serve as an advocate for the patient and thereby support the patients’ autonomy. GPs should actively discuss the results of the interdisciplinary case conference with patients and collaboratively decide on further actions. Patient participation in the interdisciplinary case conference could be another way to increase the effects of the intervention by empowering patients to not just passively receive the intervention.

Trial registration
DRKS00017795 German Clinical Trials Register, 17Nov2021, version 05.
Communication during telemedicine consultations in general practice: perspectives from general practitioners and their patients
Authors: Nguyen Amy D , White Sarah J. , Tse Tim , Cartmill John A. , Roger Peter , Hatem Sarah , Willcock Simon M. 
Published: September 2024

Abstract
Background
Telemedicine allows delivery of healthcare to occur between parties that are not in the same location. As telemedicine users are not co-present, effective communication methods are crucial to the delivery and reception of information. The aim of this study was to explore perspectives of general practitioners (GPs) and patients on the interactional components of telemedicine consultations.

Methods
Semi-structured qualitative interviews were held with telemedicine users; 15 GPs and nine patients self-selected from a larger telemedicine study. Participants were asked about their preparation for telemedicine consultations, conducting telemedicine consultations and post-consultation activities. Deidentified transcripts from the interviews were analysed thematically.

Results
GPs and patients discussed factors they used to decide whether a consultation would be best conducted by telemedicine or in-person; the condition to be discussed, the existing doctor-patient relationship and whether physical examination was required. Participants also described how they prepared for their telemedicine consultations, gathering relevant documents, and reading previous notes. Participants described strategies they employed to optimise the telemedicine interaction; improving conversational flow and building rapport, as well as difficulties they experienced when trying to provide and receive care via telemedicine.

Conclusions
Patient factors including health literacy and familiarity with technology affect the transfer of information shared during telemedicine consultations and consideration of these factors when choosing patients for telemedicine is required. Many GPs and patients have innate communication skills to effectively deliver and receive care through telemedicine. However, they may not be aware of these subconscious techniques to use to optimise telemedicine consultations. Communication training could be delivered to increase conversational flow, build rapport, and establish safety netting.
Can formal home and community-based care substitute informal care? Evidence from Chinese Longitudinal Healthy Longevity Survey
Authors: Wang Yixiao , Wu Bei , Yang Wei 
Published: September 2024

Abstract
Background
Formal home and community-based care are often considered as the preferable option to institutional care, offering older individuals the convenience of receiving care in their homes. Although research has found that these services may alleviate the burden on informal caregivers, there is a lack of research on which specific types of formal home and community-based care influence informal care provision.

Methods
Employing fixed-effects and quantile regression models, this study seeks to explore the effects that various formal home and community-based care services have on reducing the burden of informal care. This study draws data from the Chinese Longitudinal Healthy Longevity Survey 2005, 2008, 2011, 2014, and 2018.

Results
Our findings indicate that two types of formal care substantially influence the provision of informal care. The availability of daily living assistance services correlates with reduced informal caregiving hours, especially for those with extensive care needs. The availability of community-based health care services is linked to a reduction in the direct expenses incurred from informal caregiving, especially for those incurring greater direct caregiving costs. These effects are more prominent among urban residents. Other services, such as mental health support and legal advice services, do not demonstrate significant effects on reducing informal care hours and costs.

Conclusions
Daily living assistance and community-based health care services play a crucial role in benefiting informal caregivers. It is important to prioritize the expansion of these services, especially among those with greater care needs.