bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid Deposition Modeling Technology for Preparing Rocket‐Separation 3D‐Print Combination Tablet with Greater Compliance for the Treatment of Helicobacter Pylori Infection
Authors: Li Anran , Zhang Ke , Wang Zhijun , Liu Siyuan , Li Xiaofei , Ren Jianbing , Zhang Jianjun , Shi Yunyi , Gao Yuan , Qian Shuai , Wei Yuanfeng 
Published: September 2024

AbstractCurrently, standard quadruple therapy is the primary treatment for Helicobacter pylori infection; however, compliance is low due to its complicated dose regimen. 3D‐printed combination tablets offer a promising strategy to simplify dose regimens due to their flexible structure. However, it is difficult to print combination tablets with a single printing technique because of the different physicochemical properties of the drugs. In this study, a hybrid deposition modeling (HDM) 3D printer is developed for the first time, concentrating the advantages of fused deposition modeling technology and semi‐solid extrusion technology, to prepare “rocket‐separated” combination tablets containing four drugs with different release behaviors. In 0.1 m HCl medium (mimicking gastric environment), the interlayer of the tablet containing bismuth potassium citrate erodes within 5 min, then the top and bottom layers separate, with the top one floating up to the surface of the medium, starting to release metronidazole and doxycycline after 1.5 h, the omeprazole enteric bottom layer releases in PBS 6.8 medium (mimicking intestinal environment) within 2 h. Overall, this combination tablet is suitable for actual clinical needs and avoids the chance of missed or wrong dosing. Moreover, HDM technology opens the door for future integration of multiple technologies in 3D printing formulations.
Three in One: A Versatile p‐i‐n Heterojunction Diode Based on Quasi‐2D Perovskite as a Solar Cell, Red Light Emitting Device and Weak Light Photodetector
Authors: Qiu Mingxuan , Li Wanjun , Huang Xi , Liang Xiangfei , Shen Chao , Cai Wanzhu , Hou Lintao , Zhao Chuanxi , Zhao Zhijuan , Mai Wenjie 
Published: September 2024

AbstractQuasi‐two‐dimensional (Q‐2D) Ruddlesden‐Popper (RP) perovskites are rapidly developed for photoelectric device applications due to their unique multiple quantum‐well structures and adjustable photoelectric properties. Here, a three‐in‐one multifunctional photoelectric device that integrates photovoltaic (PV), electroluminescence (EL), and photodetection performance based on Q‐2D perovskite, which has not yet been reported, is explored and realized. As a solar cell (SC) mode under standard air mass 1.5G illumination, the optimal device has a power conversion efficiency (PCE) of 10.36%; as a light emitting diode (LED) mode under forward bias, the optimal device emits red light at 753 nm and achieves an EL external quantum efficiency (EQEEL) of 0.42%; as a photodetector (PD) mode under a pulsed laser (660 nm), the optimal device exhibits superior weak‐light detection, with a linear dynamic range (LDR) improvement as wide as 161.8 dB, a high detectivity (D*) of 7.88 × 1012 Jones, a fast rise/fall time of 19.1/35.2 µs and excellent stability. This work is of great significance to enrich the physical connotation and comprehensively improve the use efficiency of the multifunctional device.
Performance Boost by Dark Electro Treatment in MACl‐Added FAPbI3 Perovskite Solar Cells
Authors: Pylnev Mikhail , Nishikubo Ryosuke , Ishiwari Fumitaka , Wakamiya Atsushi , Saeki Akinori 
Published: September 2024

AbstractHalide anion migration in organic–inorganic metal halide perovskites significantly influences the power conversion efficiency (PCE) and hysteresis of perovskite solar cells (PSCs). These materials are sensitive to various external stimuli such as light, heat, and electrical bias, highlighting the need for novel post‐manufacturing treatment methods alongside a deeper understanding of their mechanisms. Here, a dark electro (DE) treatment is introduced that applies a negative‐positive‐negative bias to PSC under dark conditions, which is particularly effective for formamidinium (FA) lead iodide (FAPbI3) PSCs processed with a methylammonium chloride (MACl) additive. The DE treatment, followed by light soaking, results in an average PCE increase of 2.9 ± 1.8% (from an initial 18.2 ± 2.0% to 21.1 ± 0.8% after treatment) with a notable decrease in deviation. It is discovered that residual chloride anions from MACl play a critical role in the DE treatment. The migration of halide anions under a shaking electric bias is investigated using energy‐dispersive X‐ray spectroscopy (EDX) and time‐of‐flight secondary ion mass spectroscopy (TOF‐SIMS). This study elucidates the distribution and impact of residual chloride anions, providing insights into the mechanisms underlying the DE treatment.
Advancing Photocatalysis: Insights from 2D Materials and Operational Parameters for Organic Pollutants Removal
Authors: Balarabe Bachir Yaou , Atabaev Timur Sh. 
Published: September 2024

AbstractPhotocatalysis plays a crucial role in tackling environmental challenges by efficiently breaking down organic pollutants in water. This study highlights the significant contribution of 2D materials in advancing photocatalytic technology for sustainable environmental remediation. It explores various aspects of photocatalytic processes, including important performance metrics such as reaction rate, quantum yield, space yield, energy consumption, and figure of merit. The main focus is on 2D materials‐based structures, such as metal oxide supported on graphene and graphene oxides, MXene, or MoS2 (referred as 2D‐MO NPs), as well as more complex nanocomposite configurations (referred as 2D‐MO NCs). Furthermore, the research examines the complex interaction between compositional and operational factors that influence photocatalytic activity, as well as different photocatalytic mechanisms and active species. Finally, it addresses the current limitations of photocatalytic organic pollutants degradation for field applications and discusses the prospects of this technology.
Hybrid Nanoparticles Dual‐Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo
Authors: Carvalho Gabriela C. , Domingues Maria Nolasco Viseu , Marena Gabriel Davi , Mäkilä Ermei , Li Jiachen , Geertsema‐Doornbusch Gésinda , de Andrade Cleverton Roberto , Stuart Marc C. A. , Shahbazi Mohammad‐Ali , Corrêa Ione , Peterson Brandon W. , Salonen Jarno , Florindo Helena F. , Bauab Taís Maria , Chorilli Marlus , Santos Hélder A. 
Published: September 2024

AbstractVulvovaginal candidiasis represents a public health challenge due to its reports of high incidence and recurrence. These are caused by host‐related factors like compromised immune system, or pathogen‐related factors, such as resistance to antifungal agents, making this medical problem desirable to develop new therapeutic options. In this context, natural origin substances like curcumin, are increasingly treatment alternatives. However, some curcumin properties limit its therapeutic application, such as insolubility in aqueous solvents, which leads to low bioavailability. Nevertheless, nanotechnology association with drugs of plant origin proves to be a promising alternative to overcome the reported drawbacks. Despite being caused by a fungus, patients suffer significantly from the inflammation resulting from this disease, thus this study aimed to develop a hybrid carrier nanoformulation by microfluidics loaded with two drugs, benzydamine hydrochloride (an anti‐inflammatory drug) and curcumin (an antifungal drug). Transmission electron cryomicroscopy combined with energy dispersive X‐ray analysis confirmed that the nanoparticle is properly developed. Through in vitro biological studies, it is possible to observe that, in addition to being safe, the encapsulation of both drugs in the nanocarrier drastically reduced their cytotoxicity. Finally, although the final nanoformulation does not show in vitro activity, the in vivo study indicated therapeutic potential.
Regulating the Magnetic Domain of Nickle for Enhanced CO2 Electrochemical Reduction Driven by External Magnetic Field
Authors: Zhu Zhaozhao , Tang Wu , Wang Junjie , Lin Yingxi , Li Zhao , Chen Haiyuan , Niu Xiaobin , Chen Jun Song , Wu Rui 
Published: September 2024

AbstractElectrochemical reduction of carbon dioxide (CO2RR) into valuable fuels and chemicals is a highly desirable approach for achieving carbon neutrality, but it faces substantial technical hurdles. Herein, a novel ferromagnetic Ni@NC electrocatalyst is reported, composed of nickel nanoparticles embedded within a nitrogen‐doped carbon matrix. The optimal Ni@NC catalyst displays a fourfold increase in current density at 140 versus 0 mT in H‐type cell and achieves nearly 100% CO Faradaic efficiency (FECO) across a wide potential range with minimal overpotential in flow cell. Quantum diamond atomic force microscopy (QDAFM) directly demonstrates the orderly magnetic moments of the Ni@NC catalyst under the external magnetic field. Further theoretical calculations reveal that the orderly magnetic moments induced by the external magnetic field facilitate the formation of Ni–O–Ni and reduce the energy barriers of COOH* intermediates. This study underscores the potential of applying magnetic field modulation to not only enhance the catalytic efficiencies but also extend this strategy to other catalytic systems.
Within‐field variation of crop yield loss from cover crops
Authors: Girz Andrei I. , Mattila Tuomas J. 
Published: September 2024

AbstractThe amount of high‐resolution agricultural data has increased rapidly in the current decade. Integration of satellite multispectral imagery, combine harvester yield monitoring data, and soil moisture mapping allows managing for within‐field variation and better interpreting on‐farm experimentation. In this study, we investigated the effect of cover crops on yield in Finland by integrating Sentinel‐2 satellite imagery (normalized difference vegetation index), topographic soil moisture indexes, and high‐resolution yield data. The experiment was run by three farmers over 4 years and serves as an example for low‐cost on‐farm experimentation. Our results confirmed earlier findings that undersown cover crops result in approximately 5% yield loss. We also found that the effect is highly variable across farms and within fields. The highest yield losses were found in areas of the field, which were wetter in the spring seeding time. The competition between crop and cover crop could be observed in the vegetation maps for autumn and early summer. Combining NDVI and soil moisture maps allows delineating field zones, which require extra management to reduce the risk of yield loss from cover crop resource competition. Evaluating the overall effect of cover crops on yield would require replication on more farms. The within‐field variation results and workflow investigated in this study can guide placement of sampling areas within those fields.
Auxin injury on cotton, I: Aerial reflectance data, crop injury, and yield
Authors: Denton Savana , Raper Tyson , Dodds Darrin , Main Chris , Duncan Lori , Mueller Thomas 
Published: September 2024

AbstractSynthetic auxin herbicide movement onto sensitive cotton (Gossypium hirsutum L.) cultivars has impacted many US cotton hectares. The spatial scope and severity of auxin damage in‐season is typically estimated by an agronomist. The use of remote sensing technology has the potential to objectively quantify the spatial scope and severity of auxin damage. Experiments were conducted in 2019, 2020, and 2021 in Grand Junction, TN, to determine: (1) the effect of reflectance data collection timing; (2) the effect of auxin exposure timing; (3) the value of near infrared and red‐edge (RE) reflectance versus reflectance within the visible spectrum data; and (4) if/how visual injury relates to aerial reflectance data. Applications of 2,4‐D or dicamba were made to susceptible cotton cultivars at 1X, 1/4X, 1/16X, 1/64X, 1/256X, and 1/1024X rates at either matchhead square (MHS) or 2 weeks after first bloom (FB+2WK). Non‐treated controls were also included for each application timing. Aerial reflectance data were collected 7, 14, 21, and 28 days after application. Unsupervised classification of images into pixels with and without vegetation did not increase correlations between vegetation indices (VIs) and application rate. Although Vis, which generated the strongest correlations with application rate, visual injury, and relative lint yield, were generally RE based, similar correlations were also noted with visible spectrum VIs. Correlations were greater when auxin injury occurred at MHS than FB+2WK. Results suggest reflectance measured within the visible spectrum can quantify the scope and severity of auxin injury if the injury occurs early during the growing season.
The effect of allergen immunotherapy in patients with central compartment atopic disease post‐surgery
Authors: Meerwein Christian M. , Sacks Peta‐Lee , Ho Jacqueline , Choy Christine , Kalish Larry , Campbell Raewyn G , Sacks Ray R. , Harvey Richard J 
Published: September 2024

AbstractObjectiveTo assess the effect of allergen immunotherapy (AIT) on patients with central compartment atopic disease (CCAD) and house dust mite (HDM) sensitization post‐surgery.MethodsA retrospective cohort of surgically treated, HDM‐sensitized CRSwNP patients phenotyped as CCAD was assessed. Patients were divided into two groups based on whether they had AIT commenced as part of their surgical care. All AIT patients started immunotherapy prior to their surgery. The primary endpoint was reformation of middle turbinate (MT) edema 12 months postsurgery. Secondary endpoints were corticosteroid irrigation use (<4 times/week vs. ≥4 times/week, %) and the rhinologic domain of the 22‐item sino‐nasal outcome test (SNOT‐22). Demographic characteristics, concomitant asthma, smoking status, history of aspirin‐exacerbated respiratory disease, conjunctival symptoms, polysensitization, serum eosinophils (cell × 109/L), tissue eosinophilia (% > 100/HPF), and serum IgE (kU/L) were also recorded.ResultsEighty‐six CCAD patients were assessed (41 ± 14 yrs, 64% female). AIT was applied in 37% (n = 32). Baseline features were similar apart from greater conjunctival symptoms (72 vs. 45%, p = 0.02) in the AIT group. At 12 months post‐surgery, the AIT group has less MT edema (% ≥ diffuse 15.6 vs. 52.9, p < 0.01). Patients on AIT also had less pharmacotherapy requirements at 12 months (% ≥ 4/week, 37.5 vs. 79.6%, p < 0.01). The rhinologic symptoms were similar (21.1 ± 17.1 vs. 20.1 ± 21.6, p = 0.83).ConclusionsSurgery and pharmacotherapy are effective in managing CCAD, but the addition of AIT improved allergic phenomenon and allowed de‐escalation of topical therapy. Longer term studies are required to demonstrate further immunomodulation.
Patient‐derived organoid model of olfactory ensheathing cell tumor
Authors: Finlay John B. , Hachem Ralph Abi , Codd Patrick , Goldstein Bradley J. 
Published: September 2024

Key points
We developed a culture model of a human olfactory ensheathing cell tumor.
Cultured organoids resemble normal ensheathing cells.
Assays suggest that this model provides a tool for studying the roles of these glial cells in the maintenance of the peripheral olfactory system.
Construction of Chiral Covalent Organic Frameworks Through a Linker Decomposition Chiral Induction Strategy for Circularly Polarized Light Detection
Authors: Tang Xihao , Zha Jiajia , Wu Xueying , Tong Jingyi , Gu Qianfeng , Zhang Kai , Zhang Yuwei , Zheng Shengrun , Fan Jun , Zhang Weiguang , Zhang Qichun , Tan Chaoliang , Cai Songliang 
Published: September 2024

AbstractExploring new strategies for construction of chiral covalent organic frameworks (COFs) is of paramount importance yet remains a challenge. Herein, we report the rational design and construction of chiral COFs through a linker decomposition chiral induction (LDCI) strategy. Three pairs of azine‐linked chiral COFs are successfully synthesized by the condensation reactions of C3‐symmetric 4,4′,4′′‐(1,3,5‐triazine‐2,4,6‐triyl)tribenzaldehyde (Tz) with flexible chiral dihydrazide linkers derived from malic acid, aspartic acid and tartaric acid, respectively. Remarkably, upon complete or partial decomposition from flexible chiral dihydrazides to hydrazine during COF synthesis, the homochirality of these COFs, originating from the single‐handedness conformation of propeller‐like Tz cores, is well preserved. Such a stereoselective chiral memory realized via the LDCI strategy is confirmed by time‐dependent powder X‐ray diffraction (PXRD), Fourier transform infrared (FT‐IR) and diffuse reflectance circular dichroism (DRCD). Moreover, the resultant azine‐linked chiral COFs are used as the active materials to fabricate photodetectors to directly distinguish circularly polarized light (CPL), showing impressive recognition performances on the identification of left‐handed circularly (LHC) and right‐handed circularly (RHC) polarized lights. Notably, the residual undecomposed flexible chiral linkers within the COFs are found to be conducive to improving the polarization discrimination ratio. This work highlights LDCI as a new and effective strategy for constructing homochiral COFs with promising future in chiral optical application.
A Photo‐Switchable Peptide Fibril Esterase
Authors: Samanta Mousumi , Saad Noy , Wu Dinghao , Crone Niek S. A. , Abramov‐Harpaz Karina , Regev Clil , Cohen‐Luria Rivka , Boyle Aimee L. , Miller Yifat , Kros Alexander , Ashkenasy Gonen 
Published: September 2024

AbstractRecent attempts to mimic enzyme catalysis using simple, short peptides have been successful in enhancing various reactions, but the on‐demand, temporal or spatial regulation of such processes by external triggers remains a great challenge. Light irradiation is an ideal trigger for regulating molecular functionality, since it can be precisely manipulated in time and space, and because most reaction mediums do not react to light. We herein report the selection of a photo‐switchable amphiphilic peptide catalyst from a small library of isomeric peptides, each containing an azobenzene‐based light responsive group and a catalytic histidine residue. In its native fibrillar form, the selected peptide is efficiently and enantio‐selectively active for ester hydrolysis, but after irradiation by UV light inducing trans‐to‐cis azobenzene isomerization, the fibrils disassemble to amorphous aggregates that are much less catalytically active. Significantly, this esterase‐like activity can be manipulated multiple times, as the fibrillar peptide assembly is reversibly reduced and restored upon alternate irradiation by UV and visible light, respectively. We propose that this research may shine light on the origin of complex functions in early chemical evolution. Furthermore, it paves the way to regulate additional functions for peptide nanotechnology, such as replication, charge transfer, and delivery.
The Electrode/Electrolyte Interface Study during the Electrochemical CO2 Reduction in Acidic Electrolytes
Authors: Yao Yao , Delmo Ernest Pahuyo , Shao Minhua 
Published: September 2024

AbstractElectrochemical CO2 Reduction (CO2R) in acidic electrolytes has gained significant attention owing to higher carbon efficiency and stability than in alkaline counterparts. However, the proton source and the role of alkali cations for CO2R are still under debate. By using rotating ring disk electrode and surface‐enhanced infrared absorption spectroscopy, we find that a neutral/alkaline environment at the interface is necessary for CO2R even in acidic electrolytes. We also confirm that water molecules, rather than protons serve as the proton source for CO2R. Alkali cations in the outer Helmholtz plane activate H2O and promote the desorption of adsorbed carbon monoxide. Additionally, the solvated CO2, or CO2(aq), is the actual reactant for CO2R. This study provides a deeper understanding of the electrode/electrolyte interface during CO2R in acidic electrolytes and sheds light on further performance improvement of this system.
Bioactive Potential of the Sulfated Exopolysaccharides From the Brown Microalga Halamphora sp.: Antioxidant, Antimicrobial, and Antiapoptotic Profiles
Authors: Mansour Fatma Ben , Guermazi Wassim , Chamkha Mohamed , Bellassoued Khaled , Salah Hichem Ben , Harrath Abdel Halim , Aldahmash Waleed , Rahman Md Ataur , Ayadi Habib 
Published: September 2024

ABSTRACTThis study aims to investigate the physicochemical characteristics of the exopolysaccharides (EPS) extracted from the microalgae species Halamphora sp., as well as to evaluate their antioxidant, antibacterial, and anti‐apoptotic activities. The crude extracellular polysaccharides from the halophilic diatom Halamphora sp. were found to be extracellular heterosulfated anionic polysaccharides containing carbohydrates (76.33 ± 1.80%), proteins (0.15 ± 0.02%), uronic acids (5.44 ± 0.08%) and sulfate (7.56 ± 0.86%). The lowest protein (0.24%) and lipid (0.15%) contents suggested that EPS was highly pure. Gas chromatography–mass spectrometry analysis revealed that the carbohydrate fraction consisted of xylose, l‐galactose, d‐galactose, glucose, ribitol, mannose, and inositol with corresponding mole percentages of 40.55, 13.25, 13.00, 9.95, 9.82, 2.90, and 2.28, respectively. In vitro, tests showed a high total antioxidant capacity probably related to l‐galactose followed by d‐galactose, uronic acid, and ribitol. In addition, extracellular polysaccharides (EPS) demonstrated effective antimicrobial Gram + properties with inhibition zones ranging from 10 to 12 mm. Molecular docking showed an antiapoptotic effect, as the best docking score was generated due to the interaction of xylose and caspase 3 (−6.9 kcal/mol) and l‐galactose and caspase 3 (−5 kcal/mol). Overall, the findings of this study suggest the possibility of using the EPS extract of Halamphora sp. as an additive for nutraceutical and cosmetic purposes.
Harnessing Intrinsic Properties of Two‐Dimensional Materials for Advanced Electrochemical Catalytic Applications
Authors: Lee Tae Hyung , Jun Sang Eon , Choi Seungwon , Jang Ho Won 
Published: September 2024

ABSTRACTTwo‐dimensional (2D) materials have ignited extensive research across various fields due to their intrinsic structural, electronic, chemical, and mechanical properties, which are markedly different from those of conventional 3D materials. In the fields of electrochemical catalysis and gas sensing, 2D materials can play vital roles by leveraging their superiorities to accelerate interfacial charge transport and surface catalytic reactions. This review summarizes the advantages of 2D materials, including stackability, tunable bandgap, intrinsic atomic structure, flexibility, and large specific surface area. Furthermore, the recent approaches utilizing 2D materials as active catalysts and sensing materials are explored. Finally, the key challenges and prospects of 2D materials in electrochemical catalysis and gas sensing are discussed.