bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of aminoaciduria and hypoaminoacidemia in dogs with hepatocutaneous syndrome
Authors: Loftus John P. , Center Sharon A. , Lucy John M. , Stanton Julie A. , McDonough Sean P. , Peters-Kennedy Jeanine , Arceneaux Kenneth A. , Bechtold Molly A. , Bennett Courtney L. , Bradbury Christina A. , Cline Martha G. , Hall-Fonte Deborah L. , Hammer-Landrum Julie F. , Huntingford Janice L. , Marshall Jennifer , Sharpe Kristopher S. , Redin Jessica L. , Selva Samuel T. , Lucia Tomasina A. 
Published: May 2017

Abstract
OBJECTIVE To characterize aminoaciduria and plasma amino acid concentrations in dogs with hepatocutaneous syndrome (HCS).
ANIMALS 20 client-owned dogs of various breeds and ages.
PROCEDURES HCS was definitively diagnosed on the basis of liver biopsy specimens (n = 12), gross and histologic appearance of skin lesions (4), and examination of skin and liver biopsy specimens (2) and presumptively diagnosed on the basis of cutaneous lesions with compatible clinicopathologic and hepatic ultrasonographic (honeycomb or Swiss cheese pattern) findings (2). Amino acid concentrations in heparinized plasma and urine (samples obtained within 8 hours of each other) were measured by use of ion exchange chromatography. Urine creatinine concentration was used to normalize urine amino acid concentrations. Plasma amino acid values were compared relative to mean reference values; urine-corrected amino acid values were compared relative to maximal reference values.
RESULTS All dogs had generalized hypoaminoacidemia, with numerous amino acid concentrations < 50% of mean reference values. The most consistent and severe abnormalities involved glutamine, proline, cysteine, and hydroxyproline, and all dogs had marked lysinuria. Urine amino acids exceeding maximum reference values (value > 1.0) included lysine, 1-methylhistidine, and proline.
CONCLUSIONS AND CLINICAL RELEVANCE Hypoaminoacidemia in dogs with HCS prominently involved amino acids associated with the urea cycle and synthesis of glutathione and collagen. Marked lysinuria and prolinuria implicated dysfunction of specific amino acid transporters and wasting of amino acids essential for collagen synthesis. These findings may provide a means for tailoring nutritional support and for facilitating HCS diagnosis.
Assessment of the immunogenicity of rabies vaccine preserved by vaporization and delivered to the duodenal mucosa of gray foxes (Urocyon cinereoargenteus)
Authors: Smith Todd G. , Wu Xianfu , Ellison James A. , Wadhwa Ashutosh , Franka Richard , Langham Gregory L. , Skinner Brianna L. , Hanlon Cathleen A. , Bronshtein Victor L. 
Published: May 2017

Abstract
OBJECTIVE To assess the immunogenicity of thermostable live-attenuated rabies virus (RABV) preserved by vaporization (PBV) and delivered to the duodenal mucosa of a wildlife species targeted for an oral vaccination program.
ANIMALS 8 gray foxes (Urocyon cinereoargenteus).
PROCEDURES Endoscopy was used to place RABV PBV (n = 3 foxes), alginate-encapsulated RABV PBV (3 foxes), or nonpreserved RABV (2 foxes) vaccine into the duodenum of foxes. Blood samples were collected weekly to monitor the immune response. Saliva samples were collected weekly and tested for virus shedding by use of a conventional reverse-transcriptase PCR assay. Foxes were euthanized 28 days after vaccine administration, and relevant tissues were collected and tested for presence of RABV.
RESULTS 2 of 3 foxes that received RABV PBV and 1 of 2 foxes that received nonpreserved RABV seroconverted by day 28. None of the 3 foxes receiving alginate-encapsulated RABV PBV seroconverted. No RABV RNA was detected in saliva at any of the time points, and RABV antigen or RNA was not detected in any of the tissues obtained on day 28. None of the foxes displayed any clinical signs of rabies.
CONCLUSIONS AND CLINICAL RELEVANCE Results for this study indicated that a live-attenuated RABV vaccine delivered to the duodenal mucosa can induce an immune response in gray foxes. A safe, potent, thermostable RABV vaccine that could be delivered orally to wildlife or domestic animals would enhance current rabies control and prevention efforts.
Hyperreality: Pemaknaan dalam Penggunaan Game Pokemon Go
Authors: Tuela Michael , Susilo Daniel 
Published: May 2017

Penelitian ini bertujuan untuk mengetahui hiperrealitas dalam fenomena game Pokemon Go. Untuk mengetahui lebih dalam bagaimana pengaruh penggunaan teknologi augmented reality pada sebuah game Pokemon Go dan juga sudut pandang pemain game Pokemon Go yang ikut merasakan fenomena game Pokemon Go dan serta pemahaman pemain game Pokemon terhadap game Pokemon Go. Pendekatan penelitian ini menggunakan pendekatan metode penelitian kualitatif yang merupakan metode yang digunakan untuk menjelaskan dan menggambarkan fenomena – fenomena yang terjadi dengan paradigma fenomenologi. Teknik pengumpulan data yang digunakan adalah observasi, dan wawancara mendalam. Teknik analisis data menggunakan metode pendekatan fenomenologi transendental Husserl yang terdiri dari objek (benda/fenomena), kesengajaan, noema, noesis, intersubjektif, intuisi, dan juga makna/esensi objek. Hasil dari penelitian ini menunjukan bahwa hiperrealitas yang terdapat pada fenomena game Pokemon Go ialah dimana pemain game Pokemon Go merasa sedang berada pada dunianya sendiri dimana terdapat banyak monster – monster pokemon serta arena – arena bermain seperti pokestop dan juga gym dan para pemain dengan sesuka hati melakukan aktivitas mereka di dunia permainan mereka sendiri, dimana makna, tanda, kode sudah tidak berlaku lagi. Kata Kunci: Pokemon Go, Hiperealitas, Makna
Facing the Indonesian Media Conglomeration: Action of Preservation on Political Interest
Authors: Susilo Daniel 
Published: May 2017

After 1999, Indonesia's Media became grown up. It is the implication of the fallen of the authoritarian regime, Suharto. The growth has another side effect about trends of media conglomeration. Indonesian Media Conglomerate such as Tanoesoedibjo, Tandjung, Paloh and Bakrie also have the background as a politician. Mass media are an efficient tool to change the mind of people. Mass society theory makes several basic assumptions about individuals, the role of media, and the nature of social change. Media owner used their media for preserving his political influences. Facing this situation, Indonesian regulation about media ownership ignored by media owners. They used their power in the political area to get away from the regulation. Whereas, in Indonesian Law Number 32, issued on 2002 about Broadcasting Media, Especially on Chapter 36 verse 4 states, "broadcast content must be maintained neutrality and should not put the interests of a group". Many complain from the media audience, but no action from the government. The regulator doesn't enforce the law, especially at Broadcast Media. Most of the press uses the public sphere, who design for democratisation process, not for individual or political party's interest. Keywords: media conglomeration, Indonesia, Politics
A Dark Asteroid Family in the Phocaea Region
Authors: Novaković Bojan , Tsirvoulis Georgios , Granvik Mikael , Todović Ana 
Published: May 2017

Abstract
We report the discovery of a new asteroid family among the dark asteroids residing in the Phocaea region the Tamara family. We make use of available physical data to separate asteroids in the region according to their surface reflectance properties, and establish the membership of the family. We determine the slope of the cumulative magnitude distribution of the family, and find it to be significantly steeper than the corresponding slope of all the asteroids in the Phocaea region. This implies that subkilometer dark Phocaeas are comparable in number to bright S-type objects, shedding light on an entirely new aspect of the composition of small Phocaea asteroids. We then use the Yarkovsky V-shape based method and estimate the age of the family to be 264 ± 43 Myr. Finally, we carry out numerical simulations of the dynamical evolution of the Tamara family. The results suggest that up to 50 Tamara members with absolute magnitude

may currently be found in the near-Earth region. Despite their relatively small number in the near-Earth space, the rate of Earth impacts by small, dark Phocaeas is non-negligible.
OGLE-2016-BLG-1003: First Resolved Caustic-crossing Binary-source Event Discovered by Second-generation Microlensing Surveys
Authors: Jung Y. K. , Udalski A. , Bond I. A. , Yee J. C. , Gould A. , Han C. , Albrow M. D. , Lee C.-U. , Kim S.-L. , Hwang K.-H. , Chung S.-J. , Ryu Y.-H. , Shin I.-G. , Zhu W. , Cha S.-M. , Kim D.-J. , Lee Y. , Park B.-G. , Kim H.-W. , Pogge R. W. ,   (The KMTNet Collaboration), Skowron J. , Szymański M. K. , Poleski R. , Mróz P. , Kozłowski S. , Pietrukowicz P. , Soszyński I. , Ulaczyk K. , Pawlak M. ,   (The OGLE Collaboration), Abe F. , Bennett D. P. , Barry R. , Sumi T. , Asakura Y. , Bhattacharya A. , Donachie M. , Fukui A. , Hirao Y. , Itow Y. , Koshimoto N. , Li M. C. A. , Ling C. H. , Masuda K. , Matsubara Y. , Muraki Y. , Nagakane M. , Rattenbury N. J. , Evans P. , Sharan A. , Sullivan D. J. , Suzuki D. , Tristram P. J. , Yamada T. , Yamada T. , Yonehara A. ,   (The MOA Collaboration)
Published: May 2017

Abstract
We report the analysis of the first resolved caustic-crossing binary-source microlensing event OGLE-2016-BLG-1003. The event is densely covered by round-the-clock observations of three surveys. The light curve is characterized by two nested caustic-crossing features, which is unusual for typical caustic-crossing perturbations. From the modeling of the light curve, we find that the anomaly is produced by a binary source passing over a caustic formed by a binary lens. The result proves the importance of high-cadence and continuous observations, and the capability of second-generation microlensing experiments to identify such complex perturbations that are previously unknown. However, the result also raises the issues of the limitations of current analysis techniques for understanding lens systems beyond two masses and of determining the appropriate multiband observing strategy of survey experiments.
Occurrence of Radio Minihalos in a Mass-limited Sample of Galaxy Clusters
Authors: Giacintucci Simona , Markevitch Maxim , Cassano Rossella , Venturi Tiziana , Clarke Tracy E. , Brunetti Gianfranco 
Published: May 2017

Abstract
We investigate the occurrence of radio minihalos—diffuse radio sources of unknown origin observed in the cores of some galaxy clusters—in a statistical sample of 58 clusters drawn from the Planck Sunyaev–Zel’dovich cluster catalog using a mass cut (M
500 > 6 × 1014
M
⊙). We supplement our statistical sample with a similarly sized nonstatistical sample mostly consisting of clusters in the ACCEPT X-ray catalog with suitable X-ray and radio data, which includes lower-mass clusters. Where necessary (for nine clusters), we reanalyzed the Very Large Array archival radio data to determine whether a minihalo is present. Our total sample includes all 28 currently known and recently discovered radio minihalos, including six candidates. We classify clusters as cool-core or non-cool-core according to the value of the specific entropy floor in the cluster center, rederived or newly derived from the Chandra X-ray density and temperature profiles where necessary (for 27 clusters). Contrary to the common wisdom that minihalos are rare, we find that almost all cool cores—at least 12 out of 15 (80%)—in our complete sample of massive clusters exhibit minihalos. The supplementary sample shows that the occurrence of minihalos may be lower in lower-mass cool-core clusters. No minihalos are found in non-cool cores or “warm cores.” These findings will help test theories of the origin of minihalos and provide information on the physical processes and energetics of the cluster cores.
The Stellar Initial Mass Function in Early-type Galaxies from Absorption Line Spectroscopy. III. Radial Gradients
Authors: van Dokkum Pieter , Conroy Charlie , Villaume Alexa , Brodie Jean , Romanowsky Aaron J. 
Published: May 2017

Abstract
There is good evidence that the centers of massive early-type galaxies have a bottom-heavy stellar initial mass function (IMF) compared to that of the Milky Way. Here we study the radial variation of the IMF within such galaxies, using a combination of high-quality Keck spectroscopy and a new suite of stellar population synthesis models that cover a wide range in metallicity. As in the previous studies in this series, the models are fitted directly to the spectra and treat all elemental abundance ratios as free parameters. Using newly obtained spectroscopy for six galaxies, including deep data extending to

∼
1

R

e

for the galaxies NGC 1407, NGC 1600, and NGC 2695, we find that the IMF varies strongly with galactocentric radius. For all six galaxies the IMF is bottom-heavy in the central regions, with average mass-to-light ratio “mismatch” parameter

α
≡

(

M

/

L
)

/

(

M

/

L
)

MW

≈
2.5

at R = 0. The IMF rapidly becomes more bottom-light with increasing radius, flattening off near the Milky Way value (

α
≈
1.1

) at

R
>
0.4

R

e

. A consequence is that the luminosity-weighted average IMF depends on the measurement aperture: within

R
=

R

e

we find

〈
α

〉

L

=
1.3
–
1.5

, consistent with recent lensing and dynamical results from SLACS and

ATLAS

3
D

. Our results are also consistent with several earlier studies that were based on analyses of radial gradients of line indices. The observed IMF gradients support galaxy formation models in which the central regions of massive galaxies had a different formation history than their outer parts. Finally, we make use of the high signal-to-noise central spectra of NGC 1407 and NGC 2695 to demonstrate how we can disentangle IMF effects and abundance effects.
Les chants des poètes improvisateurs du Nordeste brésilien. Expression de l’attachement de migrants à leur terroir
Authors: Rougier Thierry 
Published: May 2017

Les repentistas de Pernambuco, Paraíba et Rio Grande do Norte sont des poètes populaires qui répondent aux sollicitations du public en chantant des couplets entièrement improvisés. Ils expriment l’attachement des gens du Nordeste brésilien à leur culture et à leur terroir. Dans un contexte d’émigration et d’exode rural, ils portent une nostalgie (« saudade »). Les improvisateurs incarnent l’archétype du migrant, leurs performances contribuant à la perpétuelle redéfinition d’une identité.
La pensée critique dans la sociolinguistique en France
Authors: Boutet Josiane 
Published: May 2017

La dimension critique a été aux fondements de la constitution de la sociolinguistique en France dans les années 1970. Je m’interroge sur le devenir de cette pensée critique, quarante ans plus tard. Après avoir exposé la conception bourdieusienne d’une discipline critique, je présente l’évolution de cette pensée dans la sociolinguistique française, selon trois étapes : les années 1970, période d’émergence d’une sociolinguistique critique ; les années de reflux (1990-2000) ; la situation actuelle caractérisée par une grande diversité scientifique. En quarante ans, une communauté scientifique s’est progressivement constituée à la fois sur un partage de principes théoriques et méthodologiques, et sur des controverses scientifiques, dont celle portant sur l’objet de la discipline. La sociolinguistique est en 2017 confrontée à la puissance des linguistiques formelles et à la dispersion intellectuelle du champ : pour y répondre, la sociolinguistique est en capacité de faire de l’implémentation sociale.
Forty years of speaking (of) the same (object) language – sans le savoir
Authors: Silverstein Michael 
Published: May 2017

Chacun des termes « sociolinguistique » et « anthropologie linguistique » suggère une orientation vers des disciplines d’encadrement différentes : la linguistique ou l’anthropologie, selon le cas. Pourtant, nous devons garder en mémoire que durant les quarante voire cinquante dernières années, l’objet de préoccupation scientifique de ces deux « entreprises » a été la plupart du temps le même : la corrélation entre la forme discursive, intermédiaire universel de l’interaction sociale, et le contexte se rapportant à la communication produite. Il est certain que l’accent a été mis sur des aspects différents de cette question centrale, incarnant peut-être une fonction propre à ces deux cadres disciplinaires. Mais il est important de voir l’intérêt croissant que suscitent la sociolinguistique et l’anthropologie linguistique en opposition à certains courants influents de la linguistique et de l’anthropologie, et se résumant à ce que l’on pourrait nommer « le fonctionnalisme sémiotique ».
La performance au carrefour des arts et des sciences sociales : quelles questions pour la sociolinguistique ?
Authors: Greco Luca 
Published: May 2017

Le but de cet article sera de reconstruire, d’une part, la généalogie du concept de performance dans les arts plastiques et dans les sciences sociales (sociologie, linguistique, anthropologie) et de montrer, d’autre part, comment, à la fin des années 1950 et au début des années 1960, aux États-Unis, les questionnements autour d’une nouvelle conception praxéologique de l’art croisent d’une façon intéressante et surprenante une vision dramaturgique de l’action sociale en tant que performance.	Si dans les arts plastiques, l’émergence de la « performance » en tant que pratique artistique montre, dès son émergence, un intérêt particulier pour le langage tout en interrogeant les dichotomies « scène vs coulisse », « vie vs art », etc. (Kaprow 1958, Cage 1965), nous observons, dans les sciences sociales, avec les travaux pionniers de Gurvitch (1956) et de Goffman (1959), une vision des interactions sociales au prisme de la performance et de la théâtralité.	On interrogera ainsi les conditions historiques d’émergence d’une telle rencontre, les points de dialogue possibles entre art et sciences sociales et les enjeux théoriques et épistémologiques posés par l’art et la performance pour l’étude des pratiques interactionnelles et pour l’histoire des idées en sociolinguistique.
L’odyssée de l’espace en sociolinguistique
Authors: Auzanneau Michelle , Trimaille Cyril 
Published: May 2017

L’article s’intéresse à la façon dont la sociolinguistique a, au cours de son histoire, intégré et pensé différents niveaux de l’espace comme paramètres des écologies sociolangagières. Après un bref aperçu d’appréhensions « pré-sociolinguistiques » des relations espace/langage, il recense des approches qui ont induit des « tournants » dans l’articulation du spatial et du langagier et contribué à construire un corpus théorique et un répertoire de pratiques empiriques. Dans la dernière partie, les auteurs rendent compte des renouvellements des approches et des questionnements induits notamment par l’attention accrue portée aux sujets et aux mutations sociales contemporaines qui provoquent des brouillages diatopiques telles que la démultiplication des modalités communicationnelles de mobilités.
SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans
Authors: Paik Donggi , Monahan Amanda , Caffrey Daniel R. , Elling Roland , Goldman William E. , Silverman Neal 
Published: May 2017

Abstract
Tracheal cytotoxin (TCT), a monomer of DAP-type peptidoglycan from Bordetella pertussis, causes cytopathology in the respiratory epithelia of mammals and robustly triggers the Drosophila Imd pathway. PGRP-LE, a cytosolic innate immune sensor in Drosophila, directly recognizes TCT and triggers the Imd pathway, yet the mechanisms by which TCT accesses the cytosol are poorly understood. In this study, we report that CG8046, a Drosophila SLC46 family transporter, is a novel transporter facilitating cytosolic recognition of TCT, and plays a crucial role in protecting flies against systemic Escherichia coli infection. In addition, mammalian SLC46A2s promote TCT-triggered NOD1 activation in human epithelial cell lines, indicating that SLC46As is a conserved group of peptidoglycan transporter contributing to cytosolic immune recognition.
Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+ T Cells
Authors: Sato Kyosuke , Kato Aiko , Sekai Miho , Hamazaki Yoko , Minato Nagahiro 
Published: May 2017

Abstract
Immune aging may underlie various aging-related disorders, including diminished resistance to infection, chronic inflammatory disorders, and autoimmunity. PD-1+ and CD153+ CD44high CD4+ T cells with features of cellular senescence, termed senescence-associated T (SA-T) cells, increasingly accumulate with age and may play a role in the immune aging phenotype. In this article, we demonstrate that, compared with young mice, the aged mouse environment is highly permissive for spontaneous proliferation of transferred naive CD4+ T cells, and it drives their transition to PD-1+ and CD153+ CD44high CD4+ T cells after extensive cell divisions. CD4+ T cells with essentially the same features as SA-T cells in aged mice are also generated from naive CD4+ T cells after extensive cell divisions under severe T-lymphopenic conditions by gamma irradiation or in developmental T cell defect, often in association with spontaneous germinal centers, as seen in aged mice. The increase in SA-T cells is significantly enhanced after thymectomy at the young adult stage, along with accelerated T cell homeostatic proliferation, whereas embryonic thymus implantation in the late adult stage markedly restricts the homeostatic proliferation of naive CD4+ T cells in the host and delays the increase in SA-T cells. Our results suggest that reduced T cell output due to physiologic thymic involution underlies the age-dependent accumulation of SA-T cells as a result of increasing homeostatic proliferation of naive CD4+ T cells. SA-T cells may provide a suitable biomarker of immune aging, as well as a potential target for controlling aging-related disorders.
The Terror of Time: Pinter's A Kind of Alaska
Authors: Hall Ann C. 
Published: May 2017

Abstract
This article examines theatrical and cinematic time in two works inspired by Oliver Sacks's book Awakenings (1973): Pinter's A Kind of Alaska (1983) and the film Awakenings (1990). In both works, characters are confronted by the passage of time, but as a result of the differences between the theatrical and film media, time is presented very differently, with Pinter's work resisting the continuity presumed in film. The article references the history of time and studies in time and literature.