bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Temperature Constitutive Model Development for Alloy 617
Authors: Quayyum Shahriar , Pritchard Patrick Graham , Hassan Tasnim 
Published: December 2017

One of the most challenging tasks in the design code development for Next Generation Nuclear Plant (NGNP) is the design of intermediate heat exchanger (IHX), whose operation temperature may range from 800°C–950°C (1472°F–1742°F). The ASME design code does not have any design provisions for any material at this temperature range. Hence, different candidate materials are under consideration for IHX and one of the leading candidate materials is Ni based Alloy 617. The operating temperature of IHX will be in the creep regime of Alloy 617 and low-cycle creep-fatigue and creep-ratcheting failure mechanisms of Alloy 617 need to be understood. This study is developing a unified constitutive model (UCM) for Alloy 617 based on a broad set of uniaxial and multiaxial creep-fatigue and creep-ratcheting experiments at high temperatures. The experiments were conducted at different temperatures, loading rates and strain ranges prescribing different loading histories. The unified constitutive model was developed based on the Chaboche viscoplastic model framework. Model improvement was performed by including cyclic hardening/softening, dynamic and static recovery, strain rate and strain range dependence, nonproportional loading parameter and multiaxial ratcheting features. The simulated responses of the modified UCM were compared against the broad range of experimental data to demonstrate the robustness of the improved model. The strengths and shortcomings of the model are discussed.
Paper published with permission.
The Application of Elevated Temperature Materials for USC Boilers in China
Authors: Xu Tong , Shou Binan , Wang Hankui , Sun Chao 
Published: December 2017

In this paper, the history of elevated temperature material production in China was reviewed, and the application status of elevated temperature materials for USC boilers in China was introduced. A comparison of Chinese standard GB5310 and ASME relevant codes of elevated temperature material designations was also proposed. Finally, statistical analysis of chemical compositions and mechanical properties of some domestic and imported material productions, including T/P91 and T/P92, was presented.
Paper published with permission.
Evaluation of Limit Load Analysis Methods Applied to High Temperature Design: Part 1 — Consistent Material Modeling
Authors: Dewees Dave , Jain Rahul 
Published: December 2017

Design-by-Rule codes (i.e. ASME Section I, EN 12952) already exist for elevated temperature (creep) design and have been successfully used for decades; however, there is motivation to optimize designs, or to assess non-standard ones. Limit Load Analysis (LLA) is the simplest advanced analysis method, and a powerful and widely-used tool for establishing compliance with required pressure part safety margins for operation at temperatures below the creep range. However, there is no direct relationship between LLA and elevated temperature allowable stresses and failure modes, such that the basic LLA methods or results must be manipulated in some way to be generally meaningful. With this in mind, review of proposed elevated temperature LLA methods (which are discussed in Part 2 of this work) by comparison to detailed transient inelastic finite element analysis allows for rigorous assessment of simplifications. Specification of an elevated temperature material model that is consistent with traditional allowable stresses for the detailed analysis is described in this paper (Part 1), and the material model and simplified methods are applied to the case of a typical steam header in the next (Part 2).
Paper published with permission.
Nuclear Island Basemat Modeling for Generation III Nuclear Power Plant Design in China
Authors: Shang Ziduan , Wu Chunhua , Han Boyu , Chang Chenyu , Zhang Lutong 
Published: December 2017

Nuclear Island (NI) basemat is a very thick reinforced concrete mat sitting on sub-grade soil to function as one-piece-foundation to support all super-structures anchored above the basemat. The Generation III (GEN III) NI is designed with more structures housing on the basemat, as such it is even greater in dimensions compared to GEN II. In the design process of a GEN III Passive-Safety-Plant (PSP), NI base mat is the most critical part for foundation design, since it is not only serves as the pressure boundary in foundation system but also support the whole nuclear island, carrying vertical load from upper structures, seismic loads both in vertical and horizontal directions, lateral soil pressures and buoyant force due to water table etc. For a typical AP plant the main structural systems which are housing within NI comprises of steel containment vessel (SCV), shield building (SC wall), internal structures, and auxiliary buildings etc. The scope for this paper is to investigate the approach and method which are suitable for modeling GEN III passive-safety-plant basemat. The investigation scopes are focused on (1) concrete basemat FE modeling and related subgrade medium (soil) modeling; (2) Design loads evaluation method and application for a typical basemat FE static analysis. Structurally speaking SCV is designed to directly anchored in concrete basemat, the interface between upper structure and foundation, its geometry and connection are unique and complicated, this lead to the modeling of basemat not only have to consider an appropriate FE meshing and element type selection but also need to consider the load application and transferring from the SCV to the basemat basin.
Since passive-safety-plant NI basemat is a deep foundation, basemat is deeply buried below the grade, the complete foundation model not only shall consider the basemat and immediate soil under the basemat, but also need to consider the backfill soil, the surrounding soil in vicinity, fill concrete under the basemat and deeper soil condition under the basemat. Since seismic loads pose great effects on basemat and its foundation design, how to evaluation seismic loadings and simplified their application for basemat static analysis is critical for such type of foundation.
Development of Analysis Method for Impact and Splash Behavior of Water-Filled Tank
Authors: Takazawa Hidekazu , Hirosaka Kazuma , Miyazaki Katsumasa , Tohyama Norihide , Matsumoto Naomi 
Published: December 2017

A new Japanese nuclear regulation requirement prepares estimating the possible damage to plant structures due to acts of terrorism, such as intentional aircraft impact. Aircraft impact needs to be considered in existing nuclear power plants. The structural damage and fuel splash behavior after aircraft impact into plant structures can be estimated using finite element analysis (FEA). FEA needs validated experimental data to determine the reliability of results.
In this study, an analysis method was validated using a simple model such as a cylindrical tank. Numerical simulations were conducted to estimate the impact and splash behavior for a water-filled cylindrical tank. The simulated results were compared with the test results of the VTT Technical Research Centre of Finland. Simulations were carried out using a multipurpose FEA code LS-DYNA®. The cylindrical tank was modeled using a shell element, and filled water was modeled using a smoothed particle hydrodynamics (SPH) element. First, two analysis models were used to estimate the effect of the number of SPH elements. One was generated with about 300,000 SPH elements. The other was generated with 37,000 SPH elements. The cylindrical tank ruptured in the longitudinal direction after impact into a rigid wall, and the filled water splashed. Few differences emerged in the simulated results using different numbers of SPH elements. The impact test of the VTT was simulated with an arbitrary Lagrangian-Eulerian (ALE) element to consider the air drag. The analytical splash pattern and history of splash velocity ratio agreed well with the impact test results.
Greyscale and contrast enhanced ultrasonography for characterization of gastric malignant tumors
Authors: Neciu Cristian Vasile , Puia Ion Cosmin , Badea Alexandru Florin , Socaciu Mihai , Botan Emil , Chiorean Ioana , Opincariu Iulian , Iancu Cornel , Badea Radu 
Published: December 2017

Aims: To evaluate the utility of grey scale ultrasonography (US) and contrast enhanced ultrasonography (CEUS) for characterization of malignant gastric tumors.Material and methods: The study was conducted prospectively and it included a number of 30 patients with malignant gastric tumors diagnosed through upper tract endoscopy and biopsy: 25 adenocarcinomas, 3 lymphomas, and 2 stromal tumors. All the patients were examined by US, followed immediately by CEUS, using both oral and intravenous contrast agents. CEUS assessed the dynamics of the contrast agent during the arterial phase and the venous phase. The distribution characteristics of the contrast agent inside the region of interest (ROI) were also evaluated. Twenty four patients underwent surgery.Results: Adenocarcinomas presented heterogeneous enhancement with variable pattern, followed by a delayed wash-out in almost all of the situations. Lymphomas presented a variable pattern, intensity and homogeneity of the enhancement, followed by delayed wash-out. Stromal tumors showed early arterial intense and homogenous enhancement followed by moderate wash-out in venous phase.Conclusions: Grey scale US and CEUS are useful methods in characterizing gastric tumors and contribute to a more adequate evaluation of the lesions. The dynamics of the contrast agent may be suggestive for the anatomopathological nature of the tumor. Larger studies will be necessary in order to determine thepractical value of the method.
New clues from Earth’s most elusive impact crater: Evidence of reidite in Australasian tektites from Thailand
Authors: Cavosie Aaron J. , Timms Nicholas E. , Erickson Timmons M. , Koeberl Christian 
Published: December 2017

Abstract
Australasian tektites are enigmatic drops of siliceous impact melt found in an ∼8000 × ∼13,000 km strewn field over Southeast Asia and Australia, including sites in both the Indian and Pacific oceans. These tektites formed only 790,000 yr ago from an impact crater estimated to be 40–100 km in diameter; yet remarkably, the young and presumably large structure remains undiscovered. Here we report new evidence of a rare high-pressure phase in Australasian tektites that further constrains the location of the source crater. The former presence of reidite, a high-pressure polymorph of zircon, was detected in granular zircon grains within Muong Nong–type tektites from Thailand. The zircon grains are surrounded by tektite glass and are composed of micrometer-sized neoblasts that contain inclusions of ZrO2. Each grain consists of neoblasts in three distinct crystallographic orientations as measured by electron backscatter diffraction, where all [001] directions are orthogonal and aligned with one &lt;110&gt; direction from the other two orientations. The systematic orientation relationships among zircon neoblasts are a hallmark of the high-pressure polymorphic transformation to reidite and subsequent reversion to zircon. The preserved microstructures and dissociation of zircon to ZrO2 and SiO2 require a pressure &gt;30 GPa and a temperature &gt;1673 °C, which represent the most extreme conditions thus far reported for Australasian Muong Nong–type tektites. The data presented here place further constraints on the distribution of high-pressure phases in Australasian tektites, including coesite and now reidite, to an area centered over Southeast Asia, which appears to be the most likely location of the source crater.
Latest Neoproterozoic to Cambrian detrital zircon facies of western Laurentia
Authors: Matthews William , Guest Bernard , Madronich Lauren 
Published: December 2017

Abstract
Late Neoproterozoic to Cambrian sandstone units are common in western Laurentia and record initial transgression of the craton after the formation of the western passive margin during the latest Neoproterozoic to earliest Cambrian. Detrital zircon measurements from 42 latest Neoproterozoic to Cambrian basal Sauk sequences and five older Neoproterozoic sandstone samples from a region extending from the Mexico–United States border to central British Columbia, Canada, are combined with previous results to characterize sediment source areas and dispersal systems. Detrital zircon populations in Neoproterozoic and Cambrian sedimentary rocks are divided into six facies based on a statistical comparison using multidimensional scaling. Detrital zircon facies are found in unique geographical regions reflecting proximity to the major tectonic provinces of Laurentia. Samples from northern regions are dominated by Archean and Paleoproterozoic zircons derived from Archean tectonic provinces and the orogenic belts that record the assembly of the Laurentian craton. More southerly sample locations show an increase in detrital zircons derived from younger Paleoproterozoic orogenic belts and early Mesoproterozoic intrusive suites. Detrital zircons from Grenville-aged sources are common in the south. The Transcontinental Arch, a feature interpreted to have controlled large-scale sediment dispersal patterns in the mid- to late Cambrian, likely played a major role in isolating the southern and northern signatures. Our data set can be used to test tectonic models for the Cordilleran orogen that invoke Jurassic or Cretaceous collision of a ribbon continent as the driving mechanism for orogenesis. Cambrian rocks of the Cassiar-Antler platform juxtaposed with North America during the hypothetical ribbon continent collision show the same geographic distribution of detrital zircon facies as similar-aged rocks from autochthonous and parautochthonous locations on the Laurentian margin. The concordance of detrital zircon facies across the proposed suture is a negative result for models that predict large dextral displacements, on the order of 2000 km, across the suture.
Men’s health and co-residence with older generations in Russia: better or worse?
Authors: Permyakova Natalia Vadimovna , Billingsley Sunnee 
Published: December 2017

BackgroundPrevious studies show contradictory findings on the relationship between health and intergenerational living arrangements (ILAs), which may be due to variation in who selects themselves into and out of ILA. Addressing the selectivity into ILA and the health of the older generation, we assess whether there is a health-protective or health-damaging effect of ILA. We locate our study in the Russian context, where ILA is prevalent and men’s health has become a public health issue.MethodsWe apply a fixed-effects logistic regression to self-rated health status of 11 546 men aged 25 years or older who participated in at least two waves in the Russian Longitudinal Monitoring Survey from 1994 to 2015. To further isolate the health effect of ILA, we observe only associations after transitioning into or out of ILA.ResultsA transition into co-residence with an unhealthy older generation increases men’s odds of reporting poor health (OR=0.64, CI 0.44 to 0.93). A transition out of co-residence with a healthy older generation decreases men’s odds of reporting fine health by 63% (OR=0.37, CI 0.28 to 0.50), whereas continuing to live with an unhealthy older generation decreases the odds by half (OR=0.49, CI 0.38 to 0.63).ConclusionsWe reveal a health interlinkage between co-residing generations by finding a detrimental health effect of co-residence with an unhealthy older generation. No longer living with an older generation who was in fine health also negatively affects men’s health. Future studies should address heterogeneity related to the health of older generations, unobserved time-constant characteristics of younger generations and selectivity into/out of ILA.
Hemodynamics and coil distribution with changing coil stiffness and length in intracranial aneurysms
Authors: Fujimura Soichiro , Takao Hiroyuki , Suzuki Takashi , Dahmani Chihebeddine , Ishibashi Toshihiro , Mamori Hiroya , Yamamoto Makoto , Murayama Yuichi 
Published: December 2017

PurposeThe purpose of this study was to investigate hemodynamics and coil distribution with changing coil stiffness and length using the finite element method (FEM) and computational fluid dynamics (CFD) analysis.MethodsBasic side-wall and bifurcation type aneurysm models were used. Six types of coil models were generated by changing the coil stiffness and length, based on commercially available embolic coils. Coil embolization was simulated using FEM. CFD was performed to characterize the hemodynamics in the aneurysms after embolization. Coil distribution and velocity reduction in the aneurysms were evaluated.ResultsThe median value of radial coil distribution was shifted from the center to the outer side of the aneurysmal dome by changing coil stiffness: harder coils entered the outer side of the aneurysmal dome more easily. Short coils were more distributed at the neck region, since their small size made it easy for them to enter the tighter area. CFD results also indicated that velocity in the aneurysm was effectively reduced when the coils were more distributed at the neck region and the outer side of the aneurysmal dome because of the disturbance in blood inflow.ConclusionsIt is easier for coils to enter the outer side of the aneurysmal sphere when they are harder. If coils are short, they can enter tighter areas more easily. In addition, high coil density at the outer side of the aneurysmal dome and at the neck region is important to achieve effective velocity reduction.
Referral facility CT perfusion prior to inter-facility transfer in patients undergoing mechanical thrombectomy
Authors: Aghaebrahim Amin , Sauvageau Eric , Aguilar-Salinas Pedro , Cortez Gustavo , Santos Roberta , Hanel Ricardo A 
Published: December 2017

Background and purposeThe use of CT perfusion (CTP) imaging at a referring hospital is feasible and may shorten the door to puncture time for patients with acute ischemic stroke.MethodsWe conducted a single center retrospective review of a prospectively maintained database of consecutive ischemic stroke patients transferred to our center for consideration of endovascular therapy. Patients were divided into two groups. Group 1 consisted of patients transferred from facilities where CTP (using automated RAPID software) was routinely performed and group 2 consisted of patients transferred from facilities that did not perform perfusion imaging.ResultsWe identified a total of 132 patients, all of whom were transferred to our center, from April 2014 to April 2017. There were no differences in baseline characteristics between the two groups. A total of 34 patients were transferred from a facility after CTP (group 1) and 98 were transferred from a facility with no CTP (group 2). Door to puncture time was significantly shorter for patients in group 1 compared with those in group 2 (median 12 (IQR 8–16) min and 48.5 (32.8–71.8) min, respectively; P<0.001). Despite obtaining additional pre-transfer imaging in group 1, there was no difference in door in and door out times at the referring facilities compared with group 2.ConclusionsWe found that triaging from a primary stroke center after CTP RAPID was feasible and significantly reduced the door to puncture time without any significant delay in the transfer process.
SCALO
Authors: Georgakoudis Giorgis , Vandierendonck Hans , Thoman Peter , Supinski Bronis R. De , Fahringer Thomas , Nikolopoulos Dimitrios S. 
Published: December 2017

Shared memory machines continue to increase in scale by adding more parallelism through additional cores and complex memory hierarchies. Often, executing multiple applications concurrently, dividing among them hardware threads, provides greater efficiency rather than executing a single application with large thread counts. However, contention for shared resources can limit the improvement of concurrent application execution: orchestrating the number of threads used by each application and is essential.
In this article, we contribute SCALO, a solution to orchestrate concurrent application execution to increase throughput. SCALO monitors co-executing applications at runtime to evaluate their scalability. Its optimizing thread allocator analyzes these scalability estimates to adapt the parallelism of each program. Unlike previous approaches, SCALO differs by including dynamic contention effects on scalability and by controlling the parallelism during the execution of parallel regions. Thus, it improves throughput when other state-of-the-art approaches fail and outperforms them by up to 40% when they succeed.
MUC1-C Induces PD-L1 and Immune Evasion in Triple-Negative Breast Cancer
Authors: Maeda Takahiro , Hiraki Masayuki , Jin Caining , Rajabi Hasan , Tagde Ashujit , Alam Maroof , Bouillez Audrey , Hu Xiufeng , Suzuki Yozo , Miyo Masaaki , Hata Tsuyoshi , Hinohara Kunihiko , Kufe Donald 
Published: December 2017

Abstract
The immune checkpoint ligand PD-L1 and the transmembrane mucin MUC1 are upregulated in triple-negative breast cancer (TNBC), where they contribute to its aggressive pathogenesis. Here, we report that genetic or pharmacological targeting of the oncogenic MUC1 subunit MUC1-C is sufficient to suppress PD-L1 expression in TNBC cells. Mechanistic investigations showed that MUC1-C acted to elevate PD-L1 transcription by recruitment of MYC and NF-κB p65 to the PD-L1 promoter. In an immunocompetent model of TNBC in which Eo771/MUC1-C cells were engrafted into MUC1 transgenic mice, we showed that targeting MUC1-C associated with PD-L1 suppression, increases in tumor-infiltrating CD8+ T cells and tumor cell killing. MUC1 expression in TNBCs also correlated inversely with CD8, CD69, and GZMB, and downregulation of these markers associated with decreased survival. Taken together, our findings show how MUC1 contributes to immune escape in TNBC, and they offer a rationale to target MUC1-C as a novel immunotherapeutic approach for TNBC treatment.
Significance: These findings show how upregulation of the transmembrane mucin MUC1 contributes to immune escape in an aggressive form of breast cancer, with potential implications for a novel immunotherapeutic approach. Cancer Res; 78(1); 205–15. ©2017 AACR.