bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between childhood body size and seventeen adverse outcomes: analysis of 65,057 European women
Authors: Li Jingmei , Eriksson Mikael , He Wei , Hall Per , Czene Kamila 
Published: November 2017

AbstractLarge childhood body size has been consistently shown to be associated with decreased breast cancer risk. However, it is important to consider the effects of a large childhood body size on other adult diseases. It is not clear if the associations between childhood body size and adult diseases will persist if they later attain healthy weight. The associations between body size at age 7 and 17 adverse outcomes in adulthood were examined using Cox models in a Swedish study of 65,057 women. Large body size at age 7, when compared to small body size, was associated with decreased risk for breast cancer (HR [95% CI]: 0.81 [0.70–0.93]) and increased risks for anorexia (2.13 [1.63–2.77]) and bulimia (1.91 [1.35–2.70]). Neither adjusting for adult BMI nor restricting the dataset to lean adults (BMI < 25 kg/m2) attenuated the associations. While large body size at age 7 by itself was positively associated with increased risks of diabetes (1.34 [1.16–1.55]), PCOS (1.69 [1.13–2.51]) and hypertension (before age 60), the associations were no longer significant after controlling for adult BMI. No clear associations were found with the remaining adverse outcomes (cervical, uterine, melanoma, colon cancer, depression, ovarian cyst, stroke, hyperlipidemia, heart failure, myocardial infarction, and angina pectoris).
The positivity of estrogen receptor and progesterone receptor may not be associated with metastasis and recurrence in epithelial ovarian cancer
Authors: Chen Shouzhen , Dai Xujing , Gao Yifei , Shen Fang , Ding Jingxin , Chen Qi 
Published: November 2017

AbstractThe estrogen (ER) or progesterone receptors (PR) is positively associated with better clinical outcomes in ovarian cancer. Whether metastasis or recurrence of ovarian cancer is correlated with this association has not been investigated. Data on 894 women with epithelial ovarian cancer were collected and the association between ER or PR positivity and peritoneal or lymph node metastases or recurrence was analysed. ER or PR positivity was higher in high-grade, low-grade serous and endometrioid carcinoma, but lower in mucinous and clear-cell carcinoma. Significantly higher ER or PR positivity was seen in endometrioid carcinoma or high-grade serous carcinoma with peritoneal metastases, respectively, but not other subtypes. In addition, there was no significant difference in ER or PR positivity between cases with and without lymph node metastasis in these five subtypes. In recurrent high-grade serous carcinoma with peritoneal metastases (n = 103), the positivity of ER or PR was 86% and 55% respectively. Our data demonstrate that the association between ER or PR positivity and peritoneal metastases was only seen in endometrioid or high grade serous carcinoma, respectively. There was no association of ER or PR positivity and lymph node metastases. The majority of recurrent high-grade serous carcinoma with peritoneal metastases (86%) were ER positive.
A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain
Authors: Makino Hiroto , Seki Shoji , Yahara Yasuhito , Shiozawa Shunichi , Aikawa Yukihiko , Motomura Hiraku , Nogami Makiko , Watanabe Kenta , Sainoh Takeshi , Ito Hisakatsu , Tsumaki Noriyuki , Kawaguchi Yoshiharu , Yamazaki Mitsuaki , Kimura Tomoatsu 
Published: November 2017

AbstractIntervertebral disc (IVD) degeneration is a major cause of low back pain. The transcription factor c-Fos/Activator Protein-1 (AP-1) controls the expression of inflammatory cytokines and matrix metalloproteinases (MMPs) that contribute to the pathogenesis IVD degeneration. We investigated the effects of inhibition of c-Fos/AP-1 on IVD degeneration and associated pain. A selective inhibitor, T-5224, significantly suppressed the interleukin-1β-induced up-regulation ofMmp-3, Mmp-13andAdamts-5transcription in human nucleus pulposus cells and in a mouse explant culture model of IVD degeneration. We used a tail disc percutaneous needle puncture method to further assess the effects of oral administration of T-5224 on IVD degeneration. Analysis of disc height, T2-magnetic resonance imaging (MRI) findings, and histology revealed that IVD degeneration was significantly mitigated by T-5224. Further, oral administration of T-5224 ameliorated pain as indicated by the extended tail-flick latency in response to heat stimulation of rats with needle-puncture-induced IVD degeneration. These findings suggest that the inhibition of c-Fos/AP-1 prevents disc degeneration and its associated pain and that T-5224 may serve as a drug for the prevention of IVD degeneration.
Study of THz-Plasmon hybridization of a loop Yagi-Uda absorber
Authors: Pattanayak Arnab , Roy Sandipta , Rana Goutam , Duttagupta Siddhartha P. , Achanta Venu Gopal , Prabhu S. S. 
Published: November 2017

AbstractIn this article we present a three-dimensional loop Yagi-Uda array for efficient, polarization independent and directional absorption of THz radiation over a narrow frequency range (f0 = 0.657 THz & Q factor = 7.5). Unit cell of the array consists of three vertically stacked gold micro rings separated from each other by 30 µm thick SU-8 layers. The proposed array also exhibits a filtering response in its transmittance spectrum. The characteristics are explained by plasmon hybridization method. The transmission, reflection and absorption spectra of the structure are measured and they show a good agreement with corresponding simulated results.
Which Preschool Children With Specific Language Impairment Receive Language Intervention?
Authors: Wittke Kacie , Spaulding Tammie J. 
Published: November 2017

Purpose
Potential biases in service provision for preschool children with specific language impairment (SLI) were explored.

Method
In Study 1, children with SLI receiving treatment (SLI-T) and those with SLI not receiving treatment (SLI-NT) were compared on demographic characteristics and developmental abilities. Study 2 recruited children with articulation disorders receiving treatment (ARTIC-T) to determine if knowing service provision status influenced the results of Study 1.

Results
In Study 1, the SLI-T group was rated by teachers as having poorer executive functioning than children in the SLIT-NT group, and the SLI-T group also came from families whose mothers had more education. These 2 variables alone predicted SLI-T and SLI-NT group membership with 84% accuracy. In Study 2, the ARTIC-T group were perceived as having comparable executive functioning to the SLI-NT group and better than the SLI-T group, indicating that teachers' knowledge of service provision did not influence their ratings of children's executive functioning.

Discussion
Preschool children with SLI, whose mothers have higher education levels and whose teachers perceive them as having poorer executive functioning, are more likely to receive intervention. Recognizing service delivery biases is critical for improving early provision of intervention for this population.
Quasi-periodic changes in the 3D solar anisotropy of Galactic cosmic rays for 1965–2014
Authors: Modzelewska R. , Alania M. V. 
Published: November 2017

Aims. We study features of the 3D solar anisotropy of Galactic cosmic rays (GCR) for 1965−2014 (almost five solar cycles, cycles 20−24). We analyze the 27-day variations of the 2D GCR anisotropy in the ecliptic plane and the north-south anisotropy normal to the ecliptic plane. We study the dependence of the 27-day variation of the 3D GCR anisotropy on the solar cycle and solar magnetic cycle. We demonstrate that the 27-day variations of the GCR intensity and anisotropy can be used as an important tool to study solar wind, solar activity, and heliosphere.
Methods. We used the components Ar, Aϕ and At of the 3D GCR anisotropy that were found based on hourly data of neutron monitors (NMs) and muon telescopes (MTs) using the harmonic analyses and spectrographic methods. We corrected the 2D diurnal (~24-h) variation of the GCR intensity for the influence of the Earth magnetic field. We derived the north-south component of the GCR anisotropy based on the GG index, which is calculated as the difference in GCR intensities of the Nagoya multidirectional MTs.
Results. We show that the behavior of the 27-day variation of the 3D anisotropy verifies a stable long-lived active heliolongitude on the Sun. This illustrates the usefulness of the 27-day variation of the GCR anisotropy as a unique proxy to study solar wind, solar activity, and heliosphere. We distinguish a tendency of the 22-yr changes in amplitude of the 27-day variation of the 2D anisotropy that is connected with the solar magnetic cycle. We demonstrate that the amplitudes of the 27-day variation of the north-south component of the anisotropy vary with the 11-yr solar cycle, but a dependence of the solar magnetic polarity can hardly be recognized. We show that the 27-day recurrences of the GG index and the At component are highly positively correlated, and both are highly correlated with the By component of the heliospheric magnetic field.
Karotisgabel: Ort der Blutdruck- und Atmungsregulation
Authors: Corts Magga 
Published: November 2017

SummaryDie A. carotis interna und die A. carotis externa zweigen auf gleicher Höhe aus der A. carotis communis ab. Deshalb wird diese Gefäßformation auch „Karotisgabel“ genannt. Die Karotisgabel liegt ca. auf Höhe des 4. Halswirbels. Im Bereich der Karotisgabel befinden sich unter anderem zwei Typen von Rezeptoren. Über die einen kann der Blutdruck gesenkt, über die anderen die Frequenz und Tiefe der Atmung erhöht werden.
Wie statte ich meine Praxis richtig aus?
Authors: Brockmann Beate 
Published: November 2017

SummaryBei der Anschaffung diagnostischer Kleingeräte sollten Sie immer Aspekte wie Wartung, Haltbarkeit, Folgekosten und Eignung für Ihre Patienten im Blick behalten. Für die Grundausstattung müssen Sie nicht die teuersten Geräte wählen. Wichtig ist, dass diese für Ihre Therapien zweckmäßig und praktikabel sind. Die Zusatzausstattung sollte einen weiterführenden Nutzen gewährleisten. Das können Geräte sein, die Ihre diagnostischen Möglichkeiten erweitern oder spezielle Zusatzfunktionen bieten.
Überlebenswahrscheinlichkeit und Palliativversorgung – Eine empirische Analyse von Krebspatienten mittels Kaplan-Meier-Überlebensfunktionen
Authors: Plaul Cornelius 
Published: November 2017

Zusammenfassung
Einleitung Es ist das vorrangige Ziel der Palliativversorgung (PV), die Lebensqualität von unheilbar kranken Patienten zu maximieren. Dies gilt – im Gegensatz zur konventionellen medizinischen Behandlung – auch dann, wenn dafür eine mögliche Verkürzung der Überlebenszeit in Kauf genommen werden muss. Dennoch gibt es schwache Evidenz dafür, dass Palliativpatienten im Vergleich zu standardversorgten Patienten keine schlechteren Überlebenswahrscheinlichkeiten aufweisen. Dieser Fragestellung wird hier anhand eines großen Datensatzes untersucht, um eine bessere Evidenzlage zu erzielen.
Methodik Mittels Routinedaten der AOK PLUS (Sachsen und Thüringen) wurden Krebspatienten selektiert (N = 447 191). Palliativpatienten waren dabei solche, die im Beobachtungszeitraum mindestens einmal Spezialisierte ambulante Palliativversorgung (SAPV), ein stationäres Hospiz oder eine Palliativstation in Anspruch genommen haben und die gemäß ihres Inanspruchnahmeverhaltens in vier Gruppen eingeteilt worden sind. Jeder dieser vier Palliativgruppen wurde mittels Matching-Verfahrens eine angepasste Kontrollgruppe zugeordnet, die beide zusammen jeweils eine Stichprobe bilden. Betrachtet wurden alle zwischen dem 1.1.2010 und dem 31.12.2012 verstorbene Individuen (N = 63 163). Anschließend wurden für alle Gruppen Kaplan-Meier-Überlebensfunktionen und Konfidenzintervalle des Median-Sterbemonats berechnet.
Ergebnisse Bei drei von vier Stichproben ist zu fast allen Zeitpunkten ein größerer Anteil der Palliativpatienten noch am Leben als in den jeweiligen Kontrollgruppen. In allen Stichproben sind keine signifikanten Unterschiede des Median-Sterbemonats feststellbar. Bei denjenigen Palliativpatienten, deren erstmalige Inanspruchnahme mit einer Institution der PV früher als im vorletzten vollen Lebensmonat erfolgte („Langzeit-Palliativpatienten“), ist dieser Effekt noch ausgeprägter.
Diskussion Es gibt keine Überlebensnachteile für Palliativpatienten gegenüber ihren Kontrollgruppen. Die vorliegende Evidenz spricht eher für Vorteile der palliativ versorgten Patienten. Somit müssen Patienten also nicht befürchten, dass sie eine palliative Therapie mit einer reduzierten noch verbleibenden Lebenszeit „bezahlen“.
Lebendiges Mitschwingen
Authors: Sylvester Corinna 
Published: November 2017

SummaryDie Bioresonanztherapie ist eine Regulationstherapie, die mit körpereigenen Schwingungen des Patienten dessen Selbstheilungskräfte stärken kann. Wichtig sind eine ausführliche Anamnese und eine gründliche Diagnose, bevor die Therapie zum Einsatz kommt. Indikationen sind vor allem Allergien, chronische Erkrankungen, Schmerzzustände und vieles mehr. Kontraindikationen sind Schwangerschaft, Herzschrittmacher, Leukämien und andere schwere Erkrankungen, bei denen die Eigenregulation nicht mehr ausreicht.
Im Rhythmus des Lebens
Authors: Borg Helga 
Published: November 2017

SummaryAls einfaches, verträgliches und nicht-invasives Verfahren eignet sich die Magnetfeldtherapie zur therapeutischen Ergänzung in der Naturheilpraxis. Mittels pulsierender magnetischer Reize werden natürliche Schwingungen und Felder simuliert und damit zelluläre Regulationsimpulse freigesetzt. Besonders bei Heilungsstörungen, Schmerzen, dysfunktionalen und degenerativen Prozessen zeigt die Therapie gute Erfolge.
Mechanisms for science to shape US living marine resource conservation policy
Authors: Merrick Richard 
Published: November 2017

Abstract
National Oceanic and Atmospheric Administration Fisheries are responsible for the stewardship of the US living marine resources and their habitat and for providing productive and sustainable fisheries, safe sources of seafood, the recovery and conservation of protected resources, and healthy ecosystems to the nation. Their approach to conservation requires, by legislative mandates, that management be informed by science. It has evolved into a four-step approach to providing this advice: (i) the national framework for conservation science, (ii) region specific implementation, (iii) development of unbiased, scientific advice as required by the framework, and (iv) scientists acting, as appropriate, as advocates and science communicators. This approach has been a conservation success where, e.g. 92% of known managed fish stocks are no longer being overfished and 84% of known stocks are at healthy levels, with the latter including 43 stocks rebuilt from depleted levels. In a changing marine climate, it is all the more important that marine conservation decisions be driven by science.
Brahma Kumaris
Authors: Ramsay Tamasin 
Published: November 2017

The Brahma Kumaris Ishwariya Vishwa Vidyalaya (Brahma Kumaris) is categorized three ways by scholars: as a millenarian New Religious Movement, as a new religion, and as a Hindu sect. By contrast, the Brahma Kumaris members (BKs) identify their community as a spiritual movement. They do not see themselves as belonging to a religion, but to a teaching institution (primarily in Asia and the Russian Federation) or a spiritual path (primarily in Europe, North America, and Australia) that has been established to restore human souls to their original purity, thereby restoring the world to its Golden Age origins. The community was formally established in 1936, as a trust comprising young women, but its formation can be traced back to 1932. The founder was a middle-aged successful jeweler, Lekhraj Koobchand Kripalani (b. 1884–d. 1969), residing in Hyderabad (in pre-Partition India). He was of the Bhaiband caste and a devotee in the Vallabhacharya sect. Kripalani was in his fifties when he had a series of visions and internal realizations of himself as the god Vishnu and understood time as a five-thousand-year, ever-repeating cycle that would change the course of his life. During that period, those in his neighborhood—primarily women and children whose husbands were on extensive travel for work—would gather at his home in satsang. These 200–300 early devotees became known as “Om Mandli” because of their habit of chanting “om” after Lekhraj’s readings of the Bhagavad Gita. Many had visionary and transcendental experiences, and the group drew on Hindu mythology and Vedanta philosophy to make sense of their experiences. Brahmacharya (living a celibate and virtuous life to realize God) was the bedrock of the movement. In c. 1950 the small local group of kin that characterized the early gathering left Pakistan and moved to Rajasthan, India. After having been a cloistered community in the 1930s and 1940s, BKs started teaching throughout India in the 1950s, making their first international impression at the World Religious Congress in Japan in 1954. In 1971 the organization established its first overseas center in London. The early 1980s was a period of rapid expansion and legitimization: hundreds of centers were established internationally, and the Brahma Kumaris established itself as a respected nongovernmental organization (NGO) at the United Nations, a position the organization has held since 1980. The Brahma Kumaris is active at the United Nations and has several long-term NGO representatives to the United Nations. The organization now has approximately one million adherents in around 130 countries.
Translation inhibition and resource balance in the TX-TL cell-free gene expression system
Authors: Nagaraj Vijayalakshmi H , Greene James M , Sengupta Anirvan M , Sontag Eduardo D 
Published: November 2017

Abstract
Quantifying the effect of vital resources on transcription (TX) and translation (TL) helps to understand the degree to which the concentration of each resource must be regulated for achieving homeostasis. Utilizing the synthetic TX-TL system, we study the impact of nucleotide triphosphates (NTPs) and magnesium (Mg2+) on gene expression. Recent observations of the counter-intuitive phenomenon of suppression of gene expression at high NTP concentrations have led to the speculation that such suppression is due to the consumption of resources by TX, hence leaving fewer resources for TL. In this work, we investigate an alternative hypothesis: direct suppression of the TL rate via stoichiometric mismatch in necessary reagents. We observe NTP-dependent suppression even in the early phase of gene expression, contradicting the resource-limitation argument. To further decouple the contributions of TX and TL, we performed gene expression experiments with purified messenger RNA (mRNA). Simultaneously monitoring mRNA and protein abundances allowed us to extract a time-dependent translation rate. Measuring TL rates for different Mg2+ and NTP concentrations, we observe a complex resource dependence. We demonstrate that TL is the rate-limiting process that is directly inhibited by high NTP concentrations. Additional Mg2+ can partially reverse this inhibition. In several experiments, we observe two maxima of the TL rate viewed as a function of both Mg2+ and NTP concentration, which can be explained in terms of an NTP-independent effect on the ribosome complex and an NTP-Mg2+ titration effect. The non-trivial compensatory effects of abundance of different vital resources signal the presence of complex regulatory mechanisms to achieve optimal gene expression.
Does using PAs in the closed treatment of pediatric forearm fractures increase malunion risk?
Authors: Garrison Stephanie , Eismann Emily A. , Cornwall Roger 
Published: November 2017

ABSTRACT

Purpose:
This study assessed whether using physician assistants (PAs) for fracture follow-up during nonoperative management of pediatric forearm fractures was associated with an increased risk of malunion.

Methods:
The study was a retrospective review of charts of 141 children under age 18 years who were treated nonoperatively in the division of orthopedics over 12 months for forearm fractures. The effect of type and number of follow-up providers on risk of malunion was determined and controlled for fracture type, location, and initial angulation. Logistic regression, Fisher exact test, and Cochran-Armitage trend test were used to analyze the data, with P < .05 indicating statistical significance.

Results:
Using strict criteria, malunion was identified in 42 (30%) of 141 patients. Follow-up provided by even up to four PAs did not increase malunion risk. Transfer of care between two attending physicians increased malunion risk, independent of fracture characteristics.

Conclusion:
The involvement of even multiple PAs during follow-up management of nonoperatively treated pediatric forearm fractures is not associated with an increase in the risk of malunion. These findings are consistent with previous published works that highlighted the safe and valuable role PAs can play in the management of common fractures.
Ultrasound Identifies Broken Drainage Tube Postthyroidectomy
Authors: Xing Jiayi , Wang Jian , You Shanshan , Li Jianchu 
Published: November 2017

Abstract
Drains are routinely used after thyroidectomy and lateral neck dissection. In rare cases, the drainage tube is broken and retained in the neck. It is difficult to identify the sonographic features of the remnant tube due to variable reasons. However, through comparative and phantom observations, we noticed the double-tract sign of the tube wall and drainage holes as the key points to solving this problem. We report such a case of the ultrasound-guided localization of a broken drainage tube that was retained in the patient.
Fetal Splenomegaly
Authors: Moreira Marta , Brás Rafael , Gonçalves Daniela , Alencoão Inês , Inocêncio Gonçalo , Rodrigues Maria , Braga Jorge 
Published: November 2017

Abstract
Enlargement of the fetal spleen is usually found secondary to systemic diseases and is frequently associated with hepatomegaly. By far, the most common causes of fetal splenomegaly are infectious. Other etiologies responsible for this sign are hemolytic anemia, congestive cardiac failure, metabolic disorders, and rarely, leukemia, lymphoma, and histiocytosis.
We report a case of prenatal splenomegaly diagnosed at 35 weeks, confirmed in the postnatal period. The postnatal workup showed the newborn had a familial type 3 form of hemophagocytic lymphohistiocytosis (HLH).
Hemophagocytic lymphohistiocytosis is an aggressive and life-threatening syndrome of excessive immune activation. The genes implicated in the hereditary forms of the disease act in an autosomal recessive fashion.
Temporal Flap as an Option for Buconasal Fistula Closure
Authors: Carvalho de Lima do Nascimento Tuanny , Wastner Bruna da Fonseca , Biron Cassia , Romanowski Maurício , Strujak Guilherme , Scariot Rafaela , Carlini João Luiz 
Published: November 2017

Abstract
Maxillary defects with buconasal/businusal communications are situations difficult to manage and solve. Several treatment options are available on the literature, each one with its indication. Temporal muscle flap is one of these options, being a technique that requires more experience of the surgeon to be properly performed and that is mainly indicated for difficult cases, large defects and those nonresponsive to simpler techniques. The main purpose of this paper is to report 3 clinical patients of the application of the temporal muscle flap for the closure of extensive oral defects. None of the patients had necrosis, nervous deficits, or any long-term changes. The authors conclude that the use of this flap was shown to be a viable, safe technique with low complication and high success rates, which may contribute to the rehabilitation of well-indicated patients.