bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association of thyroid hormones and blood pressure in euthyroid preadolescents
Authors: Park Bo Hyun , Baik Sun Jung , Lee Hye Ah , Hong Young Sun , Kim Hae Soon , Park Hyesook 
Published: January 2016

AbstractHypertension is the leading cause of cardiovascular disease worldwide, and both high and low blood pressures are associated with various chronic diseases. Thyroid hormones have profound effects on cardiovascular function, including on blood pressure. Recent studies have shown that childhood hypertension can lead to adult hypertension. Therefore, adequate blood pressure control is important from early life. Employing a life-course approach, we aimed to investigate the association between thyroid hormones and blood pressure in children.A total of 290 children from the Ewha Woman’s University Hospital birth cohort participated in a preadolescent check-up program. We assessed the levels of serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) and the blood pressure status in these children. Thyroid hormone concentrations were measured using an electro-chemiluminescence immunoassay (ECLIA), and hypertension was defined according to the guideline of the Korea Centers for Disease Control and Prevention.The sex-, age-, and height-adjusted prevalence of hypertension was 27.0% in the present study. On regression analysis, serum FT4 showed significantly negative association with diastolic blood pressure (DBP; β=–8.24, 95% CI: –14.19–2.28, p=0.007). However, these relationships were not significant after adjustment for sex, age, and current body mass index. The levels of serum TSH showed no relationship with mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) after adjustment. No significant differences in serum TSH and FT4 levels according to hypertension status were found.These findings suggest that thyroid hormone is not independently associated with increased blood pressure in euthyroid preadolescents.
Slipped capital femoral epiphysis and associated hypothyroidism. A review of the literature with two classic case examples
Authors: Moyer James , Jacks Laura , Hunter Janel Darcy , Chan Gilbert 
Published: January 2016

AbstractSlipped capital femoral epiphysis (SCFE) is a relatively common hip disorder often seen in overweight, peripubertal children. Although the exact etiology is uncertain, it is generally accepted that underlying endocrinopathies play a role in the pathogenesis. Hypothyroidism is the endocrine disorder cited most commonly in association with SCFE, and patients often have no history of thyroid dysfunction at the time of presentation. Despite being a well-recognized risk factor, recommendations for screening thyroid function in patients with typical presentations of SCFE have not been deemed cost-effective; however, there is data to support screening for hypothyroidism in patients with atypical presentations of SCFE or short stature. Hypothyroidism may have a significant impact on healing and bone union after surgical management of SCFE and there is a paucity of case reports in the literature describing potential peri- and postoperative complications. We performed a systematic review of the literature of all reported cases of SCFE with associated hypothyroidism using the search terms, which demonstrated a physiologic relationship between hypothyroidism and SCFE. Two case reports of SCFE in patients with hypothyroidism and associated complications are presented with the literature review. There is a physiologic relationship between thyroid dysfunction and SCFE, and we postulate that profound hypothyroidism may contribute to delayed healing or nonunion in patients undergoing operative management. We support the recommendation to screen patients with short stature, atypical presentation of SCFE, or perisistent nonunion after surgery. In cases of hypothyroidism, we recommend thyroid hormone replacement and laboratory confirmation of return to euthyroid state prior to operative intervention.
Native and non-native speaker teachers: Contextualizing perceived differences in the Turkish EFL setting
Authors: Aslan Erhan , Thompson Amy S. 
Published: January 2016

Abstract
Although extensive research exists on learner perceptions of native and non-native English speaker teachers (NEST/NNEST), whether prior language learning experiences impact learner beliefs about these teachers has not been investigated. This study explores the beliefs of Turkish EFL students (n = 160) via the Beliefs about Language Teachers (BALT) questionnaire, focusing on beliefs about NESTs/NNESTs regarding ease of communication, teaching style, and classroom practices. An exploratory factor analysis (EFA) performed on the BALT resulted in a four-factor solution. The beliefs of multilinguals and bilinguals, categorized in two ways (experience with more than one foreign language vs. perceived positive language interaction [PPLI]) were compared using one-way ANOVAs, which revealed significant differences for some of the factors. There was not much of a difference in bilinguals’ and multilinguals’ beliefs of NESTs and NNESTs. The perceived effectiveness of the NESTs by the PPLI learners can be explained by those learners’ high tolerance of ambiguity in the classroom, whereas the perceived effectiveness of the NNESTs by the NPPLI learners can be explained by the desired to interact in the L1 for ambiguous situations. Implications of these findings are discussed in relation to foreign language education policies and teacher education programs.
The Influence of Rotor Unbalance on Turbocharger Rotor Dynamics
Authors: Knotek Jiří , Novotný Pavel , Maršálek Ondřej , Raffai Peter , Dlugoš Jozef 
Published: January 2016

Shrnutí
Članek analyzuje vliv nevyvahy na dynamiku rotoru turbodmychadla. Je zde prezentovan 3D vypočtovy model rotoru turbodmychadla a hydrodynamicky model kluzne ložiska. Sestaveni vysledneho vypočtoveho modelu na urovni virtualniho prototypu je provedeno v prostředi software pro řešeni dynamiky těles. Članek prezentuje vybrane vysledky, na kterych je podrobně rozebran vliv velikosti nevyvahy na dynamiku rotoru turbodmychadla.
Bayesian Analysis of a Simple Measurement Model Distinguishing between Types of Information
Authors: Lira Ignacio , Grientschnig Dieter 
Published: January 2016

Abstract
Let a quantity of interest, Y, be modeled in terms of a quantity X and a set of other quantities Z. Suppose that for Z there is type B information, by which we mean that it leads directly to a joint state-of-knowledge probability density function (PDF) for that set, without reference to likelihoods. Suppose also that for X there is type A information, which signifies that a likelihood is available. The posterior for X is then obtained by updating its prior with said likelihood by means of Bayes’ rule, where the prior encodes whatever type B information there may be available for X. If there is no such information, an appropriate non-informative prior should be used. Once the PDFs for X and Z have been constructed, they can be propagated through the measurement model to obtain the PDF for Y, either analytically or numerically. But suppose that, at the same time, there is also information of type A, type B or both types together for the quantity Y. By processing such information in the manner described above we obtain another PDF for Y. Which one is right? Should both PDFs be merged somehow? Is there another way of applying Bayes’ rule such that a single PDF for Y is obtained that encodes all existing information? In this paper we examine what we believe should be the proper ways of dealing with such a (not uncommon) situation.
Theoretical and Experimental Research of Error of Method of Thermocouple with Controlled Profile of Temperature Field
Authors: Jun Su , Kochan O. , Chunzhi Wang , Kochan R. 
Published: January 2016

Abstract
The method of study and experimental researches of the error of method of the thermocouple with controlled profile of temperature field along the main thermocouple are considered in this paper. Experimentally determined values of error of method are compared to the theoretical estimations done using Newton’s law of cooling. They converge well.
Structure and separation quality of various N- and O-donor ligands from quantum-chemical calculations
Authors: Trumm Michael , Schimmelpfennig Bernd , Geist Andreas 
Published: January 2016

Abstract
Although BTP (2,6-di(1,2,4-triazin-3-yl)pyridine) has been proven to be a highly effective N-donor ligand for the selective An(III)/Ln(III) separation, the origin of its selectivity is still under discussion. We present in this paper quantum-chemical calculations at the density functional theory (DFT) and MP2 level which highlight the role of the aquo ions in the separation process. Furthermore these data will be the reference for future force-field development to investigate the differences in An(III) complexation reactions compared to their Ln(III) counterparts.
A study of cerium extraction by TBP and TODGA using a rotating diffusion cell
Authors: Bromley Michael A. , Boxall Colin 
Published: January 2016

Abstract
For the study of the coupled interfacial-mass transfer kinetics of, inter alia, TBP, TODGA, CyMe4-BTBP and CyMe4-BTPhen based solvent extraction processes, a new rotating diffusion cell (RDC) apparatus has been established at Lancaster University. RDC studies of Ce(IV)/TBP and Ce(III)/TODGA extraction systems have been undertaken in order to improve the understanding of the chemical and kinetic processes involved. In each case, an interesting dependency on local hydrodynamics at the solution phase boundary with results suggesting that the organic extractant molecules migrate into the aqueous phase in order to capture Ce.
Carbonization of solid uranyl-ascorbate gel as an indirect step of uranium carbide synthesis
Authors: Brykala Marcin , Rogowski Marcin , Olczak Tadeusz 
Published: January 2016

Abstract
The studies of the synthesis of uranium carbide from uranyl-ascorbate gels using the complex sol-gel process (CSGP) have been carried out. The synthesis of uranyl-ascorbate mixture as liquid sol from uranium trioxide and ascorbic acid and solid gel by extraction of water from sol were carefully examined. Ascorbic acid was used as a complexing agent in complex sol-gel process and as a carbon source. The crucial step to obtain final uranium carbides from the aforementioned substrates is the carbonization process. The thermal behavior of ascorbic acid and uranyl-ascorbate gels in a nitrogen atmosphere in the temperature range of 25-900°C were investigated using TG-DTG. Furthermore, the products of the carbonization of uranyl-ascorbate gels in nitrogen, argon and vacuum atmosphere were identified by X-ray diffraction. TG-DTG was used also as a method for determining of carbon residues in the samples.
Reprocessability of molybdenum and magnesia based inert matrix fuels
Authors: Ebert Elena L. , Bukaemskiy Andrey , Sadowski Fabian , Lange Steve , Wilden Andreas , Modolo Giuseppe 
Published: January 2016

Abstract
This work focuses on the reprocessability of metallic 92Mo and ceramic MgO, which is under investigation for (Pu,MA)-oxide (MA = minor actinide) fuel within a metallic 92Mo matrix (CERMET) and a ceramic MgO matrix (CERCER). Magnesium oxide and molybdenum reference samples have been fabricated by powder metallurgy. The dissolution of the matrices was studied as a function of HNO3 concentration (1-7 mol/L) and temperature (25-90°C). The rate of dissolution of magnesium oxide and metallic molybdenum increased with temperature. While the MgO rate was independent of the acid concentration (1-7 mol/L), the rate of dissolution of Mo increased with acid concentration. However, the dissolution of Mo at high temperatures and nitric acid concentrations was accompanied by precipitation of MoO3. The extraction of uranium, americium, and europium in the presence of macro amounts of Mo and Mg was studied by three different extraction agents: tri-n-butylphosphate (TBP), N,Nʹ-dimethyl-N,Nʹ-dioctylhexylethoxymalonamide (DMDOHEMA), and N,N,N’,N’- -tetraoctyldiglycolamide (TODGA). With TBP no extraction of Mo and Mg occurred. Both matrix materials are partly extracted by DMDOHEMA. Magnesium is not extracted by TODGA (D < 0.1), but a weak extraction of Mo is observed at low Mo concentration.
Pyrochemical reprocessing of molten salt fast reactor fuel: focus on the reductive extraction step
Authors: Rodrigues Davide , Durán-Klie Gabriela , Delpech Sylvie 
Published: January 2016

Abstract
The nuclear fuel reprocessing is a prerequisite for nuclear energy to be a clean and sustainable energy. In the case of the molten salt reactor containing a liquid fuel, pyrometallurgical way is an obvious way. The method for treatment of the liquid fuel is divided into two parts. In-situ injection of helium gas into the fuel leads to extract the gaseous fission products and a part of the noble metals. The second part of the reprocessing is performed by ‘batch’. It aims to recover the fissile material and to separate the minor actinides from fission products. The reprocessing involves several chemical steps based on redox and acido-basic properties of the various elements contained in the fuel salt. One challenge is to perform a selective extraction of actinides and lanthanides in spent liquid fuel. Extraction of actinides and lanthanides are successively performed by a reductive extraction in liquid bismuth pool containing metallic lithium as a reductive reagent. The objective of this paper is to give a description of the several steps of the reprocessing retained for the molten salt fast reactor (MSFR) concept and to present the initial results obtained for the reductive extraction experiments realized in static conditions by contacting LiF-ThF4-UF4-NdF3 with a lab-made Bi-Li pool and for which extraction efficiencies of 0.7% for neodymium and 14.0% for uranium were measured. It was concluded that in static conditions, the extraction is governed by a kinetic limitation and not by the thermodynamic equilibrium.
Sorption of Sr-85 and Am-241 from liquid radioactive wastes by alginate beads
Authors: Oszczak Agata , Fuks Leon 
Published: January 2016

Abstract
The paper reports the adsorption of strontium(II) and americium(III) from aqueous solutions onto calcium alginate (CaA), barium alginate (BaA) and strontium alginate (SrA) beads. Adsorption process was studied in batch experiments as a function of the initial pH of the solution and the contact time. All sorbents were examined by the termogravimetric analysis (TG). Laboratory obtained spherical beads of CaA, BaA and SrA seem to be good metal sorbents from liquid radioactive wastes. A contact time of about 4 h and neutral pH of the initial aqueous solution have been proposed to be optimum conditions for Sr-85 and Am-241 removal from the contaminated solutions using alginate sorbents. Laboratory obtained beads of CaA, BaA and SrA are characterized by the decontamination factor (DF) equal to 85% for Sr(II) and 90% for Am(III).
Gamma radiolytic stability of CyMe4BTBP and the effect of nitric acid
Authors: Schmidt Holger , Wilden Andreas , Modolo Giuseppe , Švehla Jaroslav , Grüner Bohumir , Ekberg Christian 
Published: January 2016

Abstract
The highly selective nitrogen donor ligand CyMe4BTBP for An(III) separation by solvent extraction was irradiated in a 60Co γ-source under varying conditions. Organic solutions of 10 mmol/L ligand in 1-octanol were contacted with different concentrations of nitric acid to observe the influence of an aqueous phase during irradiation. In subsequent liquid-liquid extraction experiments, distribution ratios of 241Am and 152Eu were determined. Distribution ratios decreased with increasing absorbed dose when irradiation was performed in the absence of nitric acid. With addition of nitric acid, initial distribution ratios remained constant over the whole examined dose range up to 300 kGy. For qualitative determination of radiolysis products, HPLC-MS measurements were performed. The protective effect of nitric acid was confirmed, since in samples irradiated with acid contact, no degradation products were observed, but only addition products of the 1-octanol molecule to the CyMe4BTBP molecule.
The role of humic substances in detoxification process of the environment / Rola substancji humusowych w procesach detoksykacji środowiska
Authors: Ziółkowska Anna 
Published: January 2016

Abstract
Chemical pollution of anthropogenic origin such as heavy metals, pesticides, polycyclic aromatic hydrocarbons, polychlorinated biphenyls are some of serious threats to the environment. Their main sources are industry, transport, and agriculture. Chemical substances pollute the air, water and soil, where ultimately most of them reach and accumulate.
Soil constituent involved in the adsorption of impurities is organic matter (OM), the structure of which can be divided into three fractions: humic acids (HA), fulvic acids (FA) and humin (H). The impact of pollution with OM allows the presence of active functional groups, among others, -OH, -COOH, -NH3, -OCH3. Strongly adsorbed contaminants are not available for soil microorganisms.
Genetic, Genomic and Epigenomic Studies of Balkan Endemic Nephropathy (Ben)
Authors: Staneva Rada G. , Balabanski L. , Dimova I. , Rukova B. , Hadjidekova S. , Dimitrov P. , Simeonov V. , Ivanov S. , Vagarova R. , Malinov M. , Cukuranovic R. , Stefanovic V. , Polenakovic M. , Djonov V. , Galabov A. , Toncheva D. 
Published: January 2016

Abstract
BEN is a primary, chronic tubulointerstitial nephritis characterized with chronic anemia, absence of edema, xantoderma, normal blood pressure and normal findings on the fundus oculi. The disease is distributed in restricted areas in Bulgaria, Romania, Croatia, Bosnia, Former Yugoslavia. Despite numerous studies on genetic and environmental factors and their possible involvement in BEN, its etiopathogenesis still remains elusive.
Our recent study aim to elucidate the possible epigenetic component in BEN development. Whole genome DNA array methylation analysis was applied to compare the methylation profiles of male and female BEN patients from endemic regions in Bulgaria and Serbia and healthy controls.
All three most prominent candidate genes with aberrations in the epigenetic profile discovered with this study are involved in the inflammatory/immune processes and oncogenesis. These data are in concordance with the reported pathological alterations in BEN. This research supports the role of epigenetic changes in BEN pathology.
Exome sequencing of 22.000 genes with Illumina Nextera Exome Enrichment Kit revealed three mutant genes (CELA1, HSPG2, and KCNK5) in BEN patients which encode proteins involved in basement membrane/extracellular matrix and vascular tone, tightly connected to process of angiogenesis. We suggest that an abnormal process of angiogenesis plays a key role in the molecular pathogenesis of BEN.
New Therapies for Hepatitis C Virus
Authors: Polenakovik Hari 
Published: January 2016

Abstract
Hepatitis C virus (HCV), the major etiologic agent of "non-A, non-B hepatitis" was discovered 26 years ago. Even before its discovery, interferon-α (IFN) was already being used for treatment of this infection. The next two decades saw a series of incremental improvements of the IFN therapies by extending the duration of therapy, using IFN in combination with oral ribavirin, using pegylated IFN with ribavirin, and most recently adding oral compounds that inhibit the HCV replication (directly acting antivirals - DAAs) to that regimen. DAAs target multiple steps in the HCV life cycle and are now used in combination to treat HCV infection without the need of IFN. These IFN-free, oral DAAs regimens are highly efficacious, have minimal toxicity and are given for short duration. Approved DAAs can cure more then 90% of persons with chronic HCV infection, thereby reducing the risk of death from cirrhosis and hepatocellular carcinoma. However, these drugs are very expensive, and currently their exorbitant cost significantly restricts the access to this therapy for many HCV infected patients.
Molecular Response in Patients with Chronic Myeloid Leukemia Treated with Imatinib – Single Centre Experience
Authors: Pavkovic Marica , Angelkovic Rosica , Popova-Simjanovska Marija , Genadieva-Stavric Sonja , Cevreska Lidija , Stojanovic Aleksandar 
Published: January 2016

Abstract
Introduction of tyrosine kinase inhibitors (TKI) dramatically improves the treatment and survival of the patients with chronic myeloid leukemia (CML) in the last decade. Imatinib (IM) and other TKI induce larger percentage of complete cytogenetic response (CCyR) and major molecular response (MMR). Treatment resistance to TKIs still remains an important problem in the treatment of CML. The aim of our study was to analyze the molecular response (MR) in CML patients treated with Imatinib in our institution.
We have analyzed 53 CML patients (pts), 28 females and 25 males, treated with IM as a front or second line treatment. Only 15 pts were treated with IM as a front-line therapy, while 38 pts were pretreated with hydroxyurea or/and interferon. Median duration of CML was 6 years (range: 1 year- 17 years). Median duration of IM treatment was 3 years (range: 1 year-10 years). MR was analyzed in one up to 8 time points with Real Time Quantitative RT-PCR method.
Forty six pts (87%) had complete hematological response and 55% of pts had MMR, 13/53(24.5%) pts had MMR at 4.0-4.5 log and 16/53(30.2%) pts had MMR at 3.0-4.0 log. MMR was not achieved in 24/53(45.3%).
Our results have shown smaller percentage of patients (55%) with MMR, mostly due to the fact that larger proportion of patients (38/53) were heavily pretreated with HU or/and Interferon for a prolonged period of time, before the IM treatment. This is a major risk factor for acquisition of additional molecular and cytogenetic abnormalities responsible for IM resistance and poor treatment response.