bluuebunny/crossref_metadata_2025_split huggingface dataset:
A - 132 Perceptions of Functional Competency in Persons with Subjective Memory Complaints, Mild Cognitive Impairment, and Early Dementia of the Alzheimer’s Type
Authors: Coddaire Katelyn C , Prigatano George P 
Published: September 2024

Abstract

Objective
This study evaluated whether persons with Subject Memory Complaints (SMC) perceive their overall functional abilities differently than persons with known memory impairments. We predicted SMC persons would describe themselves as less functionally competent compared to persons with objective memory impairments while relatives would perceive them as more functionally competent than what they report.

Method
As a part of an ongoing study evaluating cognitive and motor correlates of SMC, Mild Cognitive Impairment (MCI), and early Alzheimer’s disease (ad), 10 persons with SMC, 14 with MCI, and 11 with early ad completed the Patient Competency Rating Scale (PCRS). A family member or significant other completed the Patient Competency Rating Scale-Relative Form. Subjects were matched on age, education, and sex.

Results
Self-reported competency varied across groups (p &lt; 0.05), with the SMC group reporting less competency than the MCI group but at a level of competency similar to the ad group. Relatives’ ratings were also significantly different across groups (p &lt; 0.05). SMC persons were considered by relatives as more functionally competent than the MCI and ad groups. Discrepancy scores between the PCRS and PCRS-R differed across groups (p &lt; 0.05). SMC persons underestimated their functional abilities while persons with MCI and ad overestimated their abilities.

Conclusion
The findings support the predictions and are compatible with reports in the literature. The PCRS and PCRS-R provide clinically relevant information regarding both a person’s functional abilities in everyday life (according to a relative) while also detecting potential disturbances in self-awareness. SMC patients appear to overstate their functional limitations in many domains in addition to memory.
A - 136 Clinical Features of Agrammatism in Spanish Speakers with Non-Fluent/Agrammatic Variant of Primary Progressive Aphasia (Nappa): a Case Study Analysis
Authors: Arias Elsie , Provencio Augustine , Peery Shelley , Rengifo Johanna 
Published: September 2024

Abstract

Objective
A clinical diagnosis of naPPA includes presence of agrammatism and effortful speech (Gorno-Tempini et al., 2011). Agrammatism, specifically verb agreement, has emerged as a key clinical feature distinguishing PPA subtyping in English (Thomson et al., 2012). Patterns of agrammatism in English are well-established and were thought to extend to other languages (Gorno-Tempini et al., 2004; Benedet et al., 1998). Agrammatism in post-stroke Spanish patients has unique linguistic characteristics including gender-object agreement errors (Benedet et al., 1998; Reznik et al., 1995, Ardila, 2001). Research assessing agrammatism in PPA Spanish speakers is limited (Gonzalez et al., 2022). These three cases describe gender agreement errors as a clinical feature of agrammatism in Spanish speakers with naPPA.

Method
Three Spanish-dominant patients with primary speech deficits underwent neuropsychological evaluation across three outpatient clinics and were diagnosed with naPPA (all had brain MRI, two had FDG-PET). Narrative language samples were analyzed to explore patterns of agrammatic language production.

Results
Patients made few to no verb agreement errors. Instead, common errors included inconsistent speech sounds and gender disagreement within common object-article pairings, including substitutions in Spanish-language articles like “el” or “la” (e.g., “el silla”).

Conclusions
These cases revealed gender-object agreement errors as a consistent clinical feature of agrammatism in Spanish naPPA patients. Research assessing the linguistic profiles and agrammatisms of Spanish-speaking PPA patients, with confirmatory neuroimaging and biomarker correlates, is needed to aid clinicians in differentiating PPA subtypes among Spanish speakers. This is especially important with emergence of new disease modifying treatments specifically helpful in some but not all subtypes.
A - 138 Subjective to Objective: Evaluating the Relationship of Subjective Word-Finding Complaints to Performance on Objective Measures of Language
Authors: Render Rebecca C , Marceaux Janice C , McCoy Karin , Collier Marissa 
Published: September 2024

Abstract

Objective
Individuals undergoing neuropsychological evaluation may report word-finding complaints (WFC). Low performance on naming and fluency measures has been described as indicative of word-finding difficulties; studies examining correspondence of subjective complaints with objective test performance are limited. This study aimed to assess if language test scores differed based on the presence/absence of WFC and if test scores predicted report of WFC.

Method
One-hundred eleven monolingual-English veterans who passed the TOMM and completed language measures of interest were included. Measures included Auditory Naming Test, Visual Naming Test, Boston Naming Test, Neuropsychological Assessment Battery Naming subtest, and verbal fluency measures. Sample characteristics included 86.5% men, 71.2% White/Caucasian, 9.9% Hispanic/Latino, 17.1% Black/African American, and 52.2% diagnosed with neurocognitive disorder. Seventy-five (67.6%) participants self-reported WFC. Multivariate analysis and Mann–Whitney U tests compared measures across word-finding groups. Binomial logistic regressions examined each language measure as predictors of word-finding complaints (covariates: age, education, depression; chosen based on extant research reporting association with WFC).

Results
Presence of WFC was comparable across diagnostic groups (ꭓ2 = 2.49; p = 0.115). Multivariate analysis found no difference in language performance across word-finding groups, Pillai’s Trace = 0.047, p = 0.786, ηp2 = 0.047); group distributions were equivalent across measures. Logistic regressions were non-significant for the neurocognitive disorder group. In the no neurocognitive disorder group, depression (but not language measures) was a significant predictor across models.

Conclusion
Results indicate presence of subjective WFC is not associated with language test performance, and test performance was not predictive of WFC. Depression emerged as a significant predictor of complaints among those without a neurocognitive disorder, warranting further investigation.
A - 141 The Relationship of Tumor Location and Treatment on Cognition in Long-Term IDH-Mutant Glioma Survivors
Authors: Gross Hana , Faria Caylin , Lanman Tyler , Dietrich Jorg , Shih Helen A , Parsons Michael 
Published: September 2024

Abstract

Objective
Isocitrate dehydrogenase 1 mutation (IDH-M) denotes a distinct subtype of glioma which has a relatively favorable prognosis but nevertheless requires treatment including surgery, radiation and/or chemotherapy and the tumors inevitably recur. Factors influencing cognition in long-term survivors (LTS) of IDH-M have not been well characterized. We investigated factors affecting cognition in a cohort of well characterized of IDH-M LTS.

Method
Patients (N = 65; 98.5% Caucasian; 47.7% female; Mage = 47.51; Medu = 16.06) who were at least 3 years post-IDH-M diagnosis who completed neuropsychological assessment in the Neuro-oncology division at Massachusetts General Hospital were included. Tests of processing speed, working memory, episodic memory, and executive function were analyzed along with tumor, treatment, and individual difference factors relevant to cognition. Exploratory analyses were conducted to generate hypotheses regarding factors of interest.

Results
Tumor hemisphere affected delayed recall of word list learning Z-score (F = 4.00; p = 0.024; left = −1.41; right = −0.59). Tumor lobe affected visual learning (F = 3.11; p = 0.054; frontal = −0.594; temporal = −0.807; parietal = −1.983). There were no effects of treatment type (photon vs proton radiation; single vs multi-agent chemotherapy), presence of seizures, psychiatric diagnosis, tumor subtype (oligodendroglioma/astrocytoma), grade (2,3,4) or disease duration (Mean = 9.5y; min = 3y; max = 28.8y) on cognition.

Conclusions
In this heavily treated group of IDH-M glioma LTS referred for neuropsychological evaluation, typical lateralizing/localizing cognitive deficits were revealed. However, simple dichotomies may fail to capture relevant contributors to cognitive impairment. Integration with individual factors including premorbid cognition, radiation dosimetry and brain network connectivity may be necessary to predict cognitive trajectories and outcomes.
B - 1 Cognitive Flexibility Moderates the Relationship between Trauma Symptoms and Cognitive Proficiency
Authors: Romano Lucie , Fisher Thomas , Keniston Alyssa , Lewandowski Alan , Cole JoLynn 
Published: September 2024

Abstract

Objective
This study aims to lend additional empirical support for the relationship between cognitive proficiency and trauma. Importantly, the study seeks to advance our understanding of this relationship by investigating the possible moderating role of cognitive flexibility (CF). It was hypothesized that the relationship between trauma and cognitive proficiency would be stronger for individuals with less CF.

Method
Data were collected from 75 adult participants in a private practice. The sample was predominantly White and female, and all consented to a comprehensive neuropsychological assessment following referral for inattention and personal trauma. Relevant measures included the focused anxiety-trauma subscale of the Personality Assessment Inventory, the Cognitive Processing Index of the Weschler Adult Intelligence Scale, and Trails B to determine the correlation between trauma symptoms and cognitive proficiency and to evaluate whether CF moderated the relationship.

Results
Results indicated that greater trauma symptoms were associated with lower cognitive proficiency (B = −0.448, SE = 0.090, β = −0.554, p &lt; 0.001). The interaction between trauma symptoms and CF was also significant (B = 0.007, SE = 0.002, β = 0.506, p &lt; 0.001), suggesting the effect of trauma on cognitive proficiency depended upon the level of CF. Together, the variables accounted for approximately 30% of the variance in cognitive proficiency (R2 = 0.299, F(2, 73) = 15.574, p &lt; 0.001).

Conclusion
This study supports the hypothesis that the impact of psychological trauma on cerebral efficiency is partially dependent on CF. These findings spotlight CF as a potential target for intervention to mitigate the cognitive effects of trauma.
B - 2 Life-Changing Treatment, Lifelong Challenges: a Case Study on the Neuropsychological Impact of Remission of Multiple Sclerosis Following Clinical-Trial Treatment
Authors: Romano Lucie , Fisher Thomas , Keniston Alyssa , Lewandowski Alan , Cole JoLynn 
Published: September 2024

Abstract

Objective
The impact of neurodegenerative diseases on cognitive functioning is well documented; however less is known about the lasting impacts following remission of diseases with previously limited treatability. The present case uses neuropsychological assessment in furthering the understanding of the brain-behavior relationship in a case of multiple sclerosis (MS) in remission subsequent to clinical-trial treatment complicated by a history of medical comorbidities, childhood trauma, underlying psychiatric conditions, and preexisting learning disabilities.

Method
The patient is a 45-year-old right-handed male with nine years of education, diagnosed with MS (in remission) complicated by cerebrovascular disease, myocardial infarction, cerebral vascular accident, past substance-abuse, and multisource childhood trauma., He was referred for neuropsychological evaluation by his primary-care physician pursuant to learning, attention, and emotional concerns impacted by his medical history.

Results
Neuropsychological testing reflects global cognitive deficits evidenced by difficulties with intellectual functioning, motor abilities, complex sequencing, executive functioning, problem-solving, phonemic fluency, and variable attention, which affects learning and recall tasks. A self-report of psychological functioning revealed emotional difficulties associated with anxiety, depression, health concerns, hypersensitivity, emotional discord, a history of self-harm, cognitive inefficiency, and difficulty managing anger and past and present stressors. Findings were most consistent with cognitive decline associated with medical conditions, learning difficulties, and attention deficit disorder.

Conclusions
This neuropsychological case study provides an example of the long-term consequences of neurodegenerative diseases across multiple areas of neuropsychological functioning and quality of life, even when ground-breaking and innovative medical interventions result in remission. It further emphasizes the complex interactions between neurological disease and biopsychosocial factors.
B - 4 The Neuropsychological Impact of Myocardial Infarction Induced Cerebral Hypoxia and Acute Encephalitis Following Electrocution: a Case Study
Authors: Fisher Thomas L , Romano Lucie , Keniston Alyssa , Lewandowski Alan , Cole Jolynn 
Published: September 2024

Abstract

Objective
Cerebral hypoxia and acute encephalitis subsequent to myocardial infarction (MI) are often associated with a decline in cognitive functioning (Wang et al., 2022; Caplan, 2004). While this relationship is well documented in existing literature, less research has investigated the potential nuanced cognitive and behavioral impacts of hypoxia and encephalitis due to electrocution-induced atrial fibrillation (AFib). The present case study uses neuropsychological assessment to clarify further the impact of significant electrocution and subsequent morbidities on cognition.

Method
We present a case study of a 30-year-old right-handed transgender female with 12 years of education who was referred for neuropsychological assessment pursuant to mental status changes manifested by disorientation and amnesia (the patient believed it was ten years prior) following the MI due to electrocution complicated by an estimated period of 10–15 minutes of non-responsiveness and anoxic encephalopathy.

Results
Neuropsychological assessment revealed difficulties with cognitive efficiency, language functioning, sequencing, problem-solving, complex attention, and semantic fluency. Overall, performance was inconsistent with education-weighted norms and estimated premorbid functioning. An objective measure of psychological functioning reflected a negative self-evaluation, depression, thoughts of self-harm, anxiety, and personality difficulties marked by fluctuating emotions. Findings supported a diagnosis of cognitive impairment and altered mental status associated with anoxic brain injury from the above-noted MI.

Conclusion
This case highlights the consequences of anoxic encephalopathy from MI subsequent to electrocution on cognitive, emotional, and behavioral functioning. Neuropsychological assessment provided clear evidence of cognitive impairment beyond the initial diagnoses, and further defined cognitive and behavioral correlates not explained by other dispositional variables.
B - 6 The BRIEF-2A Pattern of Self and Informant Executive Functioning Difficulties in Adults with Epilepsy
Authors: Heydari Nahal D , Sady Maegan , Moncrief Grant G , Graefe Anna C , Roth Robert M 
Published: September 2024

Abstract

Objective
People with epilepsy (PWE) commonly have executive functioning (EF) difficulties on objective testing. However, less is known about subjective EF difficulties in everyday life. We examined self- and informant-rated EF in PWE using the Behavior Rating Inventory of Executive Function for Adults-2 (BRIEF-2A). We hypothesized that PWE and their informants would endorse greater EF difficulties relative to healthy participants.

Method
Participants included 43 PWE who completed comprehensive clinical neuropsychological evaluation at a large Northeastern academic medical center, which included BRIEF-2A Informant and Self Report Forms (Age M = 40.4 ± 17.2 years, 53% female, Education M = 13.0 ± 1.8 years). Twenty-four participants completed self-reports, while 19 had both self and informant reports. The comparison sample included 43 age- and gender-matched healthy controls (HC). We analyzed BRIEF-2A subscales using MANOVAs, where elevated T scores indicated worse EF. Repeated measures ANOVAs compared self and informant ratings. Multi-rater comparisons (90% CIs) and chi-squares analyzed patterns of discrepant ratings.

Results
Self-reported EF difficulties in PWE were elevated across all scales, compared to HC (p’s0.25), with greatest difference observed for working memory (PWE = 69.7 ± 12.7, HC = 44.5 ± 16.7, ηp2 = 0.61). Similar elevations across all scales were observed for PWE informant reports (p’s0.14). PWE rated greater self-monitoring (p = 0.03, ηp2 &gt; 0.23) and emotional control (p = 0.08, ηp2 &gt; 0.16) difficulties than informants. There was 42.1–68.4% concordance between self and informant reports for PWE, compared to 84–95% in HC. Patterns of self and informant ratings were similar between PWE and HC for initiation, planning/organization, and task-monitoring (p’s &gt; 0.20).

Conclusions
PWE and their informants report high, yet relatively similar, levels of EF difficulties in daily life.
B - 9 Implications of Cognitive Reserve (CR) in Pre-Surgical Epilepsy Patients: a Case Series
Authors: Lokai Andrew , Ginalis Christine , Alluri Priyanka , Shavel Katie , Vaidya Shreya , Bender Heidi , Spat-Lemus Jessica , Sacks-Zimmerman Amanda 
Published: September 2024

Abstract

Objective
Localization-related epilepsy is a chronic neurological condition for which neurosurgical interventions are effective. The pre-surgical evaluation process requires careful analysis of neuropsychological data to localize and lateralize areas of underlying neuropathology to guide surgical planning and post-operative prognostication. While it is well-described throughout the literature that global impairments may obscure patterns of discernable neurocognitive strengths and weaknesses, specifically in pre-surgical epilepsy evaluations, less is known about the impact of cognitive reserve (CR). CR, often described in the aging literature, refers to high levels of mental reserve acquired from educational, vocational and intellectual capacities, with the potential to guard against neurocognitive decline.

Method
Four right-handed patients (ages 24–44) with localization-related, medically-refractory epilepsy with left hemisphere onset (2 temporal and 2 extra temporal onset) underwent a comprehensive neuropsychological evaluation as part of a comprehensive pre-surgical workup.

Results
The CR conglomerate for these four patients (i.e., educational, vocational attainment and scores on premorbid cognitive metrics) fell in the Very High range. Three out of four patients did not evince the clinically-significant pattern of deficit (&gt;1.5 SD lower than premorbid estimate) on verbally-mediated tasks often seen in right-handed individuals with left-sided seizure onset (i.e., diminished naming and verbal learning).

Conclusion
The reasons underlying the manifestation of definitively localizing or lateralizing neuropsychological profile differs from patient-to-patient (i.e., handedness, duration of epilepsy, structural lesion, language(s) spoken); however, CR should also be considered an important confound when interfacing with data of questionable clinical utility and prognostic value.
B - 13 Effects of Individual and Community-Level Adverse Childhood Experiences and Current Psychopathology among Monolingual Spanish-Speaking Adult Neuropsychology Referrals
Authors: Jaramillo Ruthie , Abalos Steven A , Newkirk Bailey O , Soble Jason R 
Published: September 2024

Abstract

Objective
The link between adverse childhood experiences (ACEs) and higher rates of psychopathology in adulthood has been well-established, though far less analogue research has examined this relationship among Latinx patients. This study assessed the relationship between ACEs and symptoms of anxiety, depression, and perceived stress among monolingual Spanish-speaking neuropsychology referrals.

Method
Data were culled from 27 adult neuropsychology referrals (mean age = 61.70; mean education = 8.59) neuropsychological referrals administered the ACE Questionnaire, Beck Depression Inventory (BDI-II), Geriatric Depression Scale (GDS), Beck Anxiety Inventory (BAI), and Perceived Stress Scale (PSS). Linear regression analyses examined the effect of exposure to individual (e.g., emotional, physical, sexual abuse, neglect, domestic violence) and community-level ACEs on depression, anxiety, and perceived stress symptom endorsement.

Results
Endorsement of more individual ACEs predicted higher levels of anxiety (R2 = 0.281; p = 0.009) and depression (R2 = 0.127; p = 0.075) symptoms, but not perceived stress levels (R2 = 0.037; p = 0.365. By contrast, endorsement of more community-level ACEs marginally predicted higher anxiety symptoms (R2 = 0.124; p = 0.071), but not depression symptoms (R2 = 0.020; p = 0.568) or perceived stress levels (R2 = 0.045; p = 0.319).

Conclusions
Experiencing more individual-level ACEs predicted greater anxiety and, to a lesser extent, depressive symptoms, whereas community-level ACEs did not predict similar levels of endorsement of active psychopathology among monolingual Spanish-speaking adults referred for neuropsychological evaluation. Findings emphasize the need of neuropsychologists to consider routinely assessing patient’s childhood trauma history and current psychopathology symptoms during evaluation to improve diagnostic accuracy and recommendations for Latinx patients.
B - 18 Effect of Automatic Approach Tendency on Neural Dynamics in Heavy Drinkers: an ERP Study
Authors: Verma Adarsh K , Kumar Adith D , Chivukula Usha , Kumar Neeraj 
Published: September 2024

Abstract

Objective
Automatic alcohol approach/avoidance tendencies play a major role in alcohol dependence, but associated interventions are seen to have negligible effects on relapse prevention due to a limited understanding and lack of focus on modulating associated neuro-cognitive mechanisms. The current work explores the automatic tendencies-based behavioral and event-related potential (ERP) differences and probes into the neurocognitive processes and responsible brain regions.

Method
The study was conducted in a laboratory setting on 19 heavy drinkers (Alc) and 20 non-drinkers (NAlc) males recruited using snowball sampling, where participants performed an Alcohol Approach-Avoidance Task (AAT), a task for assessing/categorizing participants with automatic approach (AAppr) and avoidance (AAvoi) tendencies toward alcohol during EEG recording. A 2 (group: Alc, NAlc) x 2 (automatic tendencies: approach, avoidance) ANOVA for behavioral outcomes and ANOVA with planned contrasts for Alc and NAlc, and AAppr and AAvoi groups comparisons were performed on early, mid, and late ERP measures.

Results
The group-tendency interaction significantly influenced behavioral AAT scores. At the neural level, the Alc and NAlc group differences were present at the occipital, parietal, and frontal sites. However, the AAppr and AAvoi group differences were only present at the frontal regions, and prominent for N100–200 and N350–450 amplitudes at the F4 electrode, an electrode sitting over the right dorsolateral prefrontal cortex (dLPFC), responsible for modulating attention, response inhibition, and decision-making processes.

Conclusion
The results clarify the role of frontal and right dLPFC areas in driving the differences in automatic tendencies by significantly suppressing the neural responses in heavy drinkers with approach but not avoidance tendencies.