bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Influence of Substitution Patterns in Thioether‐Based Luminophores with Aggregation‐Induced Emission Properties
Authors: Stelzer Jacqueline , Vallet Cecilia , Sowa Andrea , Gonzalez‐Abradelo Dario , Riebe Steffen , Daniliuc Constantin G. , Ehlers Martin , Strassert Cristian. A. , Knauer Shirley K. , Voskuhl Jens 
Published: January 2018

AbstractIn this work we present a full study on the influence of substitution patterns in aromatic thioether‐based luminogens with aggregation induced emission properties. To this end nine different compounds, either with nitrile groups in ortho, meta or para positions as well as phenol groups in different positions were synthesized and investigated concerning their photophysical properties. Besides that, eight compounds were obtained as single crystals for X‐ray analysis to get a deeper understanding on the packing parameters, secondary interactions as well their influence on the properties of these compounds. Time dependent density functional theory calculations helped to understand the distribution of the frontier orbitals. Moreover, these nanostructures were analysed concerning their applicability as cellular markers. We could thus show that indeed subtle differences in shape and substitution pattern dramatically influence the photophysical properties as well as cellular uptake of the compounds.
Regulation of Charge Carrier Dynamics in ZnO Microarchitecture‐Based UV/Visible Photodetector via Photonic‐Strain Induced Effects
Authors: Purusothaman Yuvasree , Alluri Nagamalleswara Rao , Chandrasekhar Arunkumar , Vivekananthan Venkateswaran , Kim Sang‐Jae 
Published: January 2018

AbstractA feasible, morphological influence on photoresponse behavior of ZnO microarchitectures such as microwire (MW), coral‐like microstrip (CMS), fibril‐like clustered microwire (F‐MW) grown by one‐step carrier gas/metal catalyst “free” vapor transport technique is reported. Among them, ZnO F‐MW exhibits higher photocurrent (IPh) response, i.e., IPh/ZnO F‐MW > IPh/ZnO CMS > IPh/ZnO MW. The unique structural alignment of ZnO F‐MW has enhanced the IPh from 14.2 to 186, 221, 290 µA upon various light intensities such as 0 to 6, 11, 17 mW cm−2 at λ405 nm. Herein, the nature of the as‐fabricated ZnO photodetector (PD) is also demonstrated modulated by tuning the inner crystals piezoelectric potential through the piezo‐phototronic effect. The IPh response of PD decreases monotonically by introducing compressive strain along the length of the device, which is due to the synergistic effect between the induced piezoelectric polarization and photogenerated charge carriers across the metal–semiconductor interface. The current behavior observed at the two interfaces acting as the source (S) and drain (D) is carefully investigated by analyzing the Schottky barrier heights (ΦSB). This work can pave the way for the development of geometrically modified strain induced performances of PD to promote next generation self‐powered optoelectronic integrated devices and switches.
Recent Advances of Flexible Data Storage Devices Based on Organic Nanoscaled Materials
Authors: Zhou Li , Mao Jingyu , Ren Yi , Han Su‐Ting , Roy Vellaisamy A. L. , Zhou Ye 
Published: January 2018

AbstractFollowing the trend of miniaturization as per Moore's law, and facing the strong demand of next‐generation electronic devices that should be highly portable, wearable, transplantable, and lightweight, growing endeavors have been made to develop novel flexible data storage devices possessing nonvolatile ability, high‐density storage, high‐switching speed, and reliable endurance properties. Nonvolatile organic data storage devices including memory devices on the basis of floating‐gate, charge‐trapping, and ferroelectric architectures, as well as organic resistive memory are believed to be favorable candidates for future data storage applications. In this Review, typical information on device structure, memory characteristics, device operation mechanisms, mechanical properties, challenges, and recent progress of the above categories of flexible data storage devices based on organic nanoscaled materials is summarized.
Voltage‐Gated Nanoparticle Transport and Collisions in Attoliter‐Volume Nanopore Electrode Arrays
Authors: Fu Kaiyu , Han Donghoon , Crouch Garrison M. , Kwon Seung‐Ryong , Bohn Paul W. 
Published: January 2018

AbstractSingle nanoparticle analysis can reveal how particle‐to‐particle heterogeneity affects ensemble properties derived from traditional bulk measurements. High‐bandwidth, low noise electrochemical measurements are needed to examine the fast heterogeneous electron‐transfer behavior of single nanoparticles with sufficient fidelity to resolve the behavior of individual nanoparticles. Herein, nanopore electrode arrays (NEAs) are fabricated in which each pore supports two vertically spaced, individually addressable electrodes. The top ring electrode serves as a particle gate to control the transport of silver nanoparticles (AgNPs) within individual attoliter volume NEAs nanopores, as shown by redox collisions of AgNPs collisions at the bottom disk electrode. The AgNP‐nanoporeis system has wide‐ranging technological applications as well as fundamental interest, since the transport of AgNPs within the NEA mimics the transport of ions through cell membranes via voltage‐gated ion channels. A voltage threshold is observed above which AgNPs are able to access the bottom electrode of the NEAs, i.e., a minimum potential at the gate electrode is required to switch between few and many observed collision events on the collector electrode. It is further shown that this threshold voltage is strongly dependent on the applied voltage at both electrodes as well as the size of AgNPs, as shown both experimentally and through finite‐element modeling. Overall, this study provides a precise method of monitoring nanoparticle transport and in situ redox reactions within nanoconfined spaces at the single particle level.
Oral Reading Accuracy: Findings and Implications From Recent Research
Authors: Rodgers Emily , D'Agostino Jerome V. , Kelly Robert H. , Mikita Clara 
Published: January 2018

AbstractThe three accuracy ranges for oral reading—easy, instructional level, and hard—are familiar to almost everyone who teaches young students just learning to read. It may come as a surprise to learn, then, that no study has yet been conducted with beginning readers to support our well‐accepted views about accuracy ranges and their role in reading development. What accuracy range is optimal? Does it really matter if a student reads with less than 90% accuracy? In this article, the authors share what they learned when they explored these questions about oral reading accuracy and student progress.
Short‐ and Long‐Term (10‐year) Results of an Organized, Population‐Based Breast Cancer Screening Program: Comparative, Observational Study from Hungary
Authors: Tóth Dezső , Varga Zsolt , Tóth Judit , Árkosy Péter , Sebő Éva 
Published: January 2018

AbstractBackgroundA nationwide breast cancer screening program was introduced in Hungary in the year 2002 for women aged 45–65 years to be performed biannually.MethodsTo investigate and report the short‐term and 10‐year follow‐up results, we analyzed our Breast Unit’s prospectively led database of screened (Group A) and age‐matched symptomatic (Group B) patients from 2002 to 2007. We compared the clinicopathologic features of tumors and the impact of screening on surgical treatment, as well as the overall (OS), disease‐specific (DSS) and disease‐free survival (DFS) of different groups.ResultsData from 208 screen‐detected and 101 symptomatic patients between 45 and 65 years of age were examined. Screen‐detected women were younger (54 vs. 58.5 years; p = 0.001) had significantly smaller tumors (15.5 vs. 17 mm; p = 0.044), and more breast‐conserving surgery (68.8 vs. 59.4%; p = 0.032). Survival statistics were not statistically different at the median follow‐up of 123 months; however, there was a trend toward improved DFS in Group A (82.7 vs. 74.3%; p = 0.074).ConclusionsOur study showed a significant reduction in rates of mastectomy in the screen‐detected group in the short term, which does not translate into better survival rates based on initial long‐term data. In order to realize the real advantage of this newly enstated screening program, a longer period of investigation is needed.
Incidence and Predictors of Unsuspected Recurrent Laryngeal Nerve Lymph Node Metastases After Neoadjuvant Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma
Authors: Li Zhi‐Gang , Zhang Xiao‐Bin , Wen Yu‐Wen , Liu Yun‐Hen , Chao Yin‐Kai 
Published: January 2018

AbstractBackgroundRadical lymph node (LN) dissection along the recurrent laryngeal nerve (RLN) area carries a substantial morbidity rate, and its usefulness in neoadjuvant chemoradiotherapy (nCRT)‐treated esophageal cancer patients remains unclear.MethodsThis study was conducted in two Asian thoracic surgery centers. Patients with esophageal squamous cell carcinoma (ESCC) who were judged to be ycN‐RLN(−) after nCRT and received bilateral RLN LN dissection were eligible. The incidence of unsuspected RLN LN involvement was analyzed, and we used least absolute shrinkage and selection operator (LASSO) regression to identify its predictors.ResultsA total of 56 patients (53 males and 3 females; mean age: 55 years) were included. The upper mediastinum—including the bilateral RLN area—was covered by the radiation field in 48 (85.3%) patients. Although all of them were judged as ycN‐RLN(−), unsuspected RLN LN involvement was identified on pathological examination in 11 (19.6%) subjects, being the only positive nodal station in seven. LASSO regression identified the pre‐nCRT RLN LN(cN‐RLN) status as the only independent predictor of ypN‐RLN positivity; in contrast, neither the tumor location nor the radiation dose to the upper mediastinum were independently associated with ypN‐RLN(+). RLN nodal dissection resulted in positive LN discovery rates of 30.8 and 10% in ycN‐RLN(−) patients who had positive and negative cN‐RLNs before nCRT, respectively. Consequently, 23.1 and 6.7% of patients in each subgroup would have been understaged in the absence of RLN nodal dissection.ConclusionNearly one‐fifth of ESCC patients who were judged to be ycN‐RLN(−) unexpectedly had positive ypN‐RLN. The pre‐nCRT cN‐RLN status plays a key role in the selection of patients that should undergo RLN LN dissection after nCRT.
In vivo biosensors: mechanisms, development, and applications
Authors: Shi Shuobo , Ang Ee Lui , Zhao Huimin 
Published: January 2018

AbstractIn vivo biosensors can recognize and respond to specific cellular stimuli. In recent years, biosensors have been increasingly used in metabolic engineering and synthetic biology, because they can be implemented in synthetic circuits to control the expression of reporter genes in response to specific cellular stimuli, such as a certain metabolite or a change in pH. There are many types of natural sensing devices, which can be generally divided into two main categories: protein-based and nucleic acid-based. Both can be obtained either by directly mining from natural genetic components or by engineering the existing genetic components for novel specificity or improved characteristics. A wide range of new technologies have enabled rapid engineering and discovery of new biosensors, which are paving the way for a new era of biotechnological progress. Here, we review recent advances in the design, optimization, and applications of in vivo biosensors in the field of metabolic engineering and synthetic biology.
Apache Struts 2: how technical and development gaps caused the Equifax Breach
Authors: Luszcz Jeff 
Published: January 2018

You already know the story: by identifying an Apache Struts CVE-2017-5638 vulnerability, criminals exposed the personal data of up to 143 million Equifax customers. What needs closer examination is the cause. The coding risk that opened up the door must be identified and closed. And just as important, companies need to examine their development processes for openings that let vulnerabilities in. Open source software (OSS) is widely used in software applications but rarely tracked in detail. Companies don't know what they don't know regarding open source and the breach teaches important lessons about the need to close that gap. An Apache Struts vulnerability allowed hackers to steal data on 143 million Equifax customers. What needs closer examination is the cause. The breach offers a reminder about how security practices play an important role in protecting a company, along with instituting security policies into engineering planning and processes. There's an opportunity for a conversation about stopping hackers in their tracks with tight processes, especially with regard to the use of open source software, explains Jeff Luszcz of Flexera.
Securing the blockchain against hackers
Authors: Boireau Olivier 
Published: January 2018

Blockchain technology is transforming the way data is shared and value is transferred. However, there remain significant obstacles that must be overcome before blockchain is ready for mainstream adoption – most notably, security. How to protect both the cryptographic keys that allow access to the ledger and blockchain applications remains a top concern for any organisation or individual interested in using blockchain to transact anything of significant value. Blockchain technology is transforming the way data is shared and value is transferred. However, security concerns must be overcome before it is ready for mainstream adoption. Protecting cryptographic keys remains a top concern. Using hardware security modules (HSMs) and trusted computers in place of digital wallets and as blockchain nodes will give security-conscious users and organisations assurance that no matter what blockchain application they choose, they have the means to protect digital assets, argues Olivier Boireau of Design SHIFT.
The Creation of the Monnet Plan, 1945–1946: A Critical Re-Evaluation– ERRATUM
Authors: BRUNET LUC-ANDRÉ 
Published: January 2018

The original version of this article was published with the incorrect author name. The author's name should have appeared as “Luc-André Brunet”.We apologise to the authors and readers for this error and reproduce the entire corrected paper on the following pages.
The amyotrophic lateral sclerosis supportive care needs assessment instrument: Development and psychometric evaluation
Authors: Oh Juyeon , Oh Seong-il , Kim Jung A 
Published: January 2018

AbstractObjectiveThe aim of the study is to develop an amyotrophic lateral sclerosis supportive care needs (ALSSCN) instrument based on Fitch's Supportive Care Needs Framework and to test its psychometric properties.MethodThis study consists of three parts: (1) item generation from the literature review and qualitative interview; (2) content validation; and (3) psychometric evaluation of the instrument. Participants who were diagnosed with ALS (n = 139) were recruited from two ALS clinics in Seoul, Korea, and Busan, Korea for the psychometric testing.ResultThe ALSSCN consisted of 37 items with seven domains: physical, psychological, emotional, spiritual, social, informational, and practical needs. The Cronbach's alpha of each domain ranged from 0.61 (social needs) to 0.90 (emotional needs). The intra-class correlation coefficient for test-retest was 0.89, indicating good test-retest reliability. The overall ALSSCN was significantly negatively correlated with the quality of life, which supported convergent validity. Confirmatory factor analysis of the ALSSCN supported a seven-factor model.Significance of resultsThe ALSSCN has acceptable internal consistency, stability, and content and construct validity in a Korean ALS population. ALSSCN is a psychometrically sound measure and can be adopted by healthcare professionals, researchers, and administrators to comprehensively assess the perceived supportive care needs of patients with ALS.
THE LOGIC AND TOPOLOGY OF KANT’S TEMPORAL CONTINUUM
Authors: PINOSIO RICCARDO , VAN LAMBALGEN MICHIEL 
Published: January 2018

AbstractIn this paper we provide a mathematical model of Kant’s temporal continuum that yields formal correlates for Kant’s informal treatment of this concept in theCritique of Pure Reasonand in other works of his critical period. We show that the formal model satisfies Kant’s synthetic a priori principles for time (whose consistence is not obvious) and that it even illuminates what “faculties and functions” must be in place, as “conditions for the possibility of experience”, for time to satisfy such principles. We then present a mathematically precise account of Kant’s transcendental theory of time—the most precise account to date.Moreover, we show that the Kantian continuum which we obtain has some affinities with the Brouwerian continuum but that it also has “infinitesimal intervals” consisting of nilpotent infinitesimals; these allow us to capture Kant’s theory of rest and motion in theMetaphysical Foundations of Natural Science.While our focus is on Kant’s theory of time the material in this paper is more generally relevant for the problem of developing a rigorous theory of the phenomenological continuum, in the tradition of Whitehead, Russell, and Weyl among others.
Fabrication of 3D air-core MEMS inductors for very-high-frequency power conversions
Authors: Le Hoa Thanh , Mizushima Io , Nour Yasser , Tang Peter Torben , Knott Arnold , Ouyang Ziwei , Jensen Flemming , Han Anpan 
Published: January 2018

AbstractWe report a fabrication technology for 3D air-core inductors for small footprint and very-high-frequency power conversions. Our process is scalable and highly generic for fabricating inductors with a wide range of geometries and core shapes. We demonstrate spiral, solenoid, and toroidal inductors, a toroidal transformer and inductor with advanced geometries that cannot be produced by wire winding technology. The inductors are embedded in a silicon substrate and consist of through-silicon vias and suspended windings. The inductors fabricated with 20 and 25 turns and 280-350 μm heights on 4-16 mm2 footprints have an inductance from 34.2 to 44.6 nH and a quality factor from 10 to 13 at frequencies ranging from 30 to 72 MHz. The air-core inductors show threefold lower parasitic capacitance and up to a 140% higher-quality factor and a 230% higher-operation frequency than silicon-core inductors. A 33 MHz boost converter mounted with an air-core toroidal inductor achieves an efficiency of 68.2%, which is better than converters mounted with a Si-core inductor (64.1%). Our inductors show good thermal cycling stability, and they are mechanically stable after vibration and 2-m-drop tests.
Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
Authors: Wang Jun , Hodes Georgia E. , Zhang Hongxing , Zhang Song , Zhao Wei , Golden Sam A. , Bi Weina , Menard Caroline , Kana Veronika , Leboeuf Marylene , Xie Marc , Bregman Dana , Pfau Madeline L. , Flanigan Meghan E. , Esteban-Fernández Adelaida , Yemul Shrishailam , Sharma Ali , Ho Lap , Dixon Richard , Merad Miriam , Han Ming-Hu , Russo Scott J. , Pasinetti Giulio M. 
Published: January 2018

AbstractMajor depressive disorder is associated with abnormalities in the brain and the immune system. Chronic stress in animals showed that epigenetic and inflammatory mechanisms play important roles in mediating resilience and susceptibility to depression. Here, through a high-throughput screening, we identify two phytochemicals, dihydrocaffeic acid (DHCA) and malvidin-3′-O-glucoside (Mal-gluc) that are effective in promoting resilience against stress by modulating brain synaptic plasticity and peripheral inflammation. DHCA/Mal-gluc also significantly reduces depression-like phenotypes in a mouse model of increased systemic inflammation induced by transplantation of hematopoietic progenitor cells from stress-susceptible mice. DHCA reduces pro-inflammatory interleukin 6 (IL-6) generations by inhibiting DNA methylation at the CpG-richIL-6sequences introns 1 and 3, while Mal-gluc modulates synaptic plasticity by increasing histone acetylation of the regulatory sequences of theRac1gene. Peripheral inflammation and synaptic maladaptation are in line with newly hypothesized clinical intervention targets for depression that are not addressed by currently available antidepressants.
Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer
Authors: Severson Tesa M. , Kim Yongsoo , Joosten Stacey E. P. , Schuurman Karianne , van der Groep Petra , Moelans Cathy B. , ter Hoeve Natalie D. , Manson Quirine F. , Martens John W. , van Deurzen Carolien H. M. , Barbe Ellis , Hedenfalk Ingrid , Bult Peter , Smit Vincent T. H. B. M. , Linn Sabine C. , van Diest Paul J. , Wessels Lodewyk , Zwart Wilbert 
Published: January 2018

AbstractMale breast cancer (MBC) is rare and poorly characterized. Like the female counterpart, most MBCs are hormonally driven, but relapse after hormonal treatment is also noted. The pan-hormonal action of steroid hormonal receptors, including estrogen receptor alpha (ERα), androgen receptor (AR), progesterone receptor (PR), and glucocorticoid receptor (GR) in this understudied tumor type remains wholly unexamined. This study reveals genomic cross-talk of steroid hormone receptor action and interplay in human tumors, here in the context of MBC, in relation to the female disease and patient outcome. Here we report the characterization of human breast tumors of both genders for cistromic make-up of hormonal regulation in human tumors, revealing genome-wide chromatin binding landscapes of ERα, AR, PR, GR, FOXA1, and GATA3 and enhancer-enriched histone mark H3K4me1. We integrate these data with transcriptomics to reveal gender-selective and genomic location-specific hormone receptor actions, which associate with survival in MBC patients.
Gene therapy for human glioblastoma using neurotropic JC virus-like particles as a gene delivery vector
Authors: Chao Chun-Nun , Yang Yu-Hsuan , Wu Mu-Sheng , Chou Ming-Chieh , Fang Chiung-Yao , Lin Mien-Chun , Tai Chien-Kuo , Shen Cheng-Huang , Chen Pei-Lain , Chang Deching , Wang Meilin 
Published: January 2018

AbstractGlioblastoma multiforme (GBM), the most common malignant brain tumor, has a short period of survival even with recent multimodality treatment. The neurotropic JC polyomavirus (JCPyV) infects glial cells and oligodendrocytes and causes fatal progressive multifocal leukoencephalopathy in patients with AIDS. In this study, a possible gene therapy strategy for GBM using JCPyV virus-like particles (VLPs) as a gene delivery vector was investigated. We found that JCPyV VLPs were able to deliver the GFP reporter gene into tumor cells (U87-MG) for expression. In an orthotopic xenograft model, nude mice implanted with U87 cells expressing the near-infrared fluorescent protein and then treated by intratumoral injection of JCPyV VLPs carrying the thymidine kinase suicide gene, combined with ganciclovir administration, exhibited significantly prolonged survival and less tumor fluorescence during the experiment compared with controls. Furthermore, JCPyV VLPs were able to protect and deliver a suicide gene to distal subcutaneously implanted U87 cells in nude mice via blood circulation and inhibit tumor growth. These findings show that metastatic brain tumors can be targeted by JCPyV VLPs carrying a therapeutic gene, thus demonstrating the potential of JCPyV VLPs to serve as a gene therapy vector for the far highly treatment-refractory GBM.