bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seizures in supratentorial meningioma: a systematic review and meta-analysis
Authors: Englot Dario J. , Magill Stephen T. , Han Seunggu J. , Chang Edward F. , Berger Mitchel S. , McDermott Michael W. 
Published: December 2015

OBJECT
Meningioma is the most common benign intracranial tumor, and patients with supratentorial meningioma frequently suffer from seizures. The rates and predictors of seizures in patients with meningioma have been significantly under-studied, even in comparison with other brain tumor types. Improved strategies for the prediction, treatment, and prevention of seizures in patients with meningioma is an important goal, because tumor-related epilepsy significantly impacts patient quality of life.

METHODS
The authors performed a systematic review of PubMed for manuscripts published between January 1980 and September 2014, examining rates of pre- and postoperative seizures in supratentorial meningioma, and evaluating potential predictors of seizures with separate meta-analyses.

RESULTS
The authors identified 39 observational case series for inclusion in the study, but no controlled trials. Preoperative seizures were observed in 29.2% of 4709 patients with supratentorial meningioma, and were significantly predicted by male sex (OR 1.74, 95% CI 1.30–2.34); an absence of headache (OR 1.77, 95% CI 1.04–3.25); peritumoral edema (OR 7.48, 95% CI 6.13–9.47); and non–skull base location (OR 1.77, 95% CI 1.04–3.25). After surgery, seizure freedom was achieved in 69.3% of 703 patients with preoperative epilepsy, and was more than twice as likely in those without peritumoral edema, although an insufficient number of studies were available for formal meta-analysis of this association. Of 1085 individuals without preoperative epilepsy who underwent resection, new postoperative seizures were seen in 12.3% of patients. No difference in the rate of new postoperative seizures was observed with or without perioperative prophylactic anticonvulsants.

CONCLUSIONS
Seizures are common in supratentorial meningioma, particularly in tumors associated with brain edema, and seizure freedom is a critical treatment goal. Favorable seizure control can be achieved with resection, but evidence does not support routine use of prophylactic anticonvulsants in patients without seizures. Limitations associated with systematic review and meta-analysis should be considered when interpreting these results.
Stroke prevention by direct revascularization for patients with adult-onset moyamoya disease presenting with ischemia
Authors: Kim Tackeun , Oh Chang Wan , Kwon O-Ki , Hwang Gyojun , Kim Jeong Eun , Kang Hyun-Seung , Cho Won-Sang , Bang Jae Seung 
Published: December 2015

OBJECT
Moyamoya disease (MMD) is a progressive disease that can cause recurrent stroke. The authors undertook this retrospective case-control study with a large sample size in an attempt to assess the efficacy of direct or combined revascularization surgery for ischemia in adults with MMD.

METHODS
The authors investigated cases involving patients with moyamoya disease presenting with ischemia who visited Seoul National University Bundang Hospital and Seoul National University Hospital between 2000 and 2014. Among 441 eligible patients, 301 underwent revascularization surgery and 140 were treated conservatively. Variables evaluated included age at diagnosis, sex, surgical record, Suzuki stage, and occurrence of stroke. Patients were stratified into 2 groups based on whether or not they had undergone revascularization surgery. Actuarial 1-, 5-, and 10-year stroke rates were calculated using the life table method. Risk factor analysis for 5-year stroke occurrence was conducted with multivariate regression.

RESULTS
Of the 441 patients, 301 had been surgically treated (revascularization group) and 140 had not (control group). The mean follow-up durations were 45 and 77 months, respectively. The actuarial 10-year cumulative incidence rate for any kind of stroke was significantly lower in the revascularization group (9.4%) than in the control group (19.6%) (p = 0.041); the relative risk reduction (RRR) was also superior (52.0%) in the revascularization group, and the number needed to treat was 10. The 10-year rate of ischemic stroke was greater (13.3%) in the control group than in the revascularization group (3.9%) (p = 0.019). The RRR for ischemic stroke in the revascularization group was 70.7%, and the number needed to treat was 11. However, the actuarial 1- and 5-year rates of ischemic stroke did not significantly differently between the groups. Overall, revascularization surgery was shown to be an independent protective factor, as revealed by multivariate analysis.

CONCLUSIONS
Direct or combined revascularization for patients with adult-onset moyamoya disease presenting with ischemia can prevent further stroke.
Panventriculomegaly with a wide foramen of Magendie and large cisterna magna
Authors: Kageyama Hiroshi , Miyajima Masakazu , Ogino Ikuko , Nakajima Madoka , Shimoji Kazuaki , Fukai Ryoko , Miyake Noriko , Nishiyama Kenichi , Matsumoto Naomichi , Arai Hajime 
Published: December 2015

OBJECT
The authors’ goal in this paper is to provide the first clinical, radiological, and genetic studies of panventriculomegaly (PaVM) defined by a wide foramen of Magendie and large cisterna magna.

METHODS
Clinical and brain imaging data from 28 PaVM patients (including 10 patients from 5 families) were retrospectively studied. Five children were included. In adult patients, the age at onset was 56.0 ± 16.7 years. Tetraventricular dilation, aqueductal opening with flow void on T2-weighted images, and a wide foramen of Magendie and large cisterna magna (wide cerebrospinal fluid space at the fourth ventricle outlet) were essential MRI findings for PaVM diagnosis. 3D fast asymmetrical spin echo sequences were used for visualization of cistern membranes. Time-spatial labeling inversion pulse examination was performed to analyze cerebrospinal fluid movement. Copy number variations were determined using high-resolution microarray and were validated by quantitative polymerase chain reaction with breakpoint sequencing.

RESULTS
Adult patients showed gait disturbance, urinary dysfunction, and cognitive dysfunction. Five infant patients exhibited macrocranium. Patients were divided into 2 subcategories, those with or without downward bulging third ventricular floors and membranous structures in the prepontine cistern. Patients with bulging floors were successfully treated with endoscopic third ventriculostomy. Genetic analysis revealed a deletion in DNAH14 that encodes a dynein heavy chain protein associated with motile cilia function, and which co-segregated with patients in a family without a downward bulging third ventricular floor.

CONCLUSIONS
Panventriculomegaly with a wide foramen of Magendie and a large cisterna magna may belong to a subtype of congenital hydrocephalus with familial accumulation, younger age at onset, and symptoms of normal pressure hydrocephalus. In addition, a family with PaVM has a gene mutation associated with dysfunction of motile cilia.
Sports participation with arachnoid cysts
Authors: Strahle Jennifer , Selzer Béla J. , Geh Ndi , Srinivasan Dushyanth , Strahle MaryKathryn , Martinez-Sosa Meleine , Muraszko Karin M. , Garton Hugh J. L. , Maher Cormac O. 
Published: December 2015

OBJECT
There is currently no consensus on the safety of sports participation for patients with an intracranial arachnoid cyst (AC). The authors' goal was to define the risk of sports participation for children with this imaging finding.

METHODS
A survey was prospectively administered to 185 patients with ACs during a 46-month period at a single institution. Cyst size and location, treatment, sports participation, and any injuries were recorded. Eighty patients completed at least 1 subsequent survey following their initial entry into the registry, and these patients were included in a prospective registry with a mean prospective follow-up interval of 15.9 ± 8.8 months.

RESULTS
A total 112 patients with ACs participated in 261 sports for a cumulative duration of 4410 months or 1470 seasons. Of these, 94 patients participated in 190 contact sports for a cumulative duration of 2818 months or 939 seasons. There were no serious or catastrophic neurological injuries. Two patients presented with symptomatic subdural hygromas following minor sports injuries. In the prospective cohort, there were no neurological injuries

CONCLUSIONS
Permanent or catastrophic neurological injuries are very unusual in AC patients who participate in athletic activities. In most cases, sports participation by these patients is safe.
Sports participation with Chiari I malformation
Authors: Strahle Jennifer , Geh Ndi , Selzer Béla J. , Bower Regina , Himedan Mai , Strahle MaryKathryn , Wetjen Nicholas M. , Muraszko Karin M. , Garton Hugh J. L. , Maher Cormac O. 
Published: December 2015

OBJECT
There is currently no consensus on the safety of sports participation for patients with Chiari I malformation (CM-I). The authors' goal was to define the risk of sports participation for children with the imaging finding of CM-I.

METHODS
A prospective survey was administered to 503 CM-I patients at 2 sites over a 46-month period. Data were gathered on imaging characteristics, treatment, sports participation, and any sport-related injuries. Additionally, 81 patients completed at least 1 subsequent survey following their initial entry into the registry and were included in a prospective group, with a mean prospective follow-up period of 11 months.

RESULTS
Of the 503 CM-I patients, 328 participated in sports for a cumulative duration of 4641 seasons; 205 of these patients participated in contact sports. There were no serious or catastrophic neurological injuries. One patient had temporary extremity paresthesias that resolved within hours, and this was not definitely considered to be related to the CM-I. In the prospective cohort, there were no permanent neurological injuries.

CONCLUSIONS
No permanent or catastrophic neurological injuries were observed in CM-I patients participating in athletic activities. The authors believe that the risk of such injuries is low and that, in most cases, sports participation by children with CM-I is safe.
Is Peritonitis Risk Increased in Elderly Patients on Peritoneal Dialysis? Report from the French Language Peritoneal Dialysis Registry (RDPLF)
Authors: Duquennoy Simon , Béchade Clémence , Verger Christian , Ficheux Maxence , Ryckelynck Jean-Philippe , Lobbedez Thierry 
Published: December 2015

Introduction This study was carried out to examine whether or not elderly patients on peritoneal dialysis (PD) had an increased risk of peritonitis. Methods This was a retrospective cohort study based on data from the French Language Peritoneal Dialysis Registry. We analyzed 8,396 incident patients starting PD between January 2003 and December 2010. The end of the observation period was 31 December 2012. Patients were separated into 2 age groups: up to 75 and over of 75 years old. Results Among 8,396 patients starting dialysis there were 3,173 patients older than 75. When using a Cox model, no association was found between age greater than 75 years and increased risk of peritonitis (hazard ratio [HR]: 0.97 [0.88 – 1.07]). Diabetes (HR: 1.14 [1.01 – 1.28] and continuous ambulatory PD (HR: 1.13 [1.04 – 1.23]) were significantly associated with a higher risk of peritoneal infection whereas nurse-assisted PD was associated with a lower risk of peritonitis (HR: 0.85 [0.78 – 0.94]. In the analysis restricted to the 3,840 self-care PD patients, there was no association between age older than 75 years and risk of peritonitis. Conclusion The risk of peritonitis is not increased in elderly patients on PD in a country where assisted PD is available.
Prevalence of Cognitive Impairment among Peritoneal Dialysis Patients, Impact on Peritonitis and Role of Assisted Dialysis
Authors: Shea Yat Fung , Lam Man Fai , Lee Mi Suen Connie , Mok Ming Yee Maggie , Lui Sing-leung , Yip Terence P.S. , Lo Wai Kei , Chu Leung Wing , Chan Tak-Mao 
Published: December 2015

Background Chronic renal failure and aging are suggested as risk factors for cognitive impairment (CI). We studied the prevalence of CI among peritoneal dialysis (PD) patients using Montreal Cognitive Assessment (MoCA), its impact on PD-related peritonitis in the first year, and the potential role of assisted PD. Methods One hundred fourteen patients were newly started on PD between February 2011 and July 2013. Montreal Cognitive Assessment was performed in the absence of acute illness. Data on patient characteristics including demographics, comorbidities, blood parameters, dialysis adequacy, presence of helpers, medications, and the number PD-related infections were collected. Results The age of studied patients was 59±15.0 years, and 47% were female. The prevalence of CI was 28.9%. Patients older than 65 years old (odds ratio [OR] 4.88, confidence interval [CI] 1.79 – 13.28 p = 0.002) and with an education of primary level or below (OR 4.08, CI 1.30 – 12.81, p = 0.016) were independent risk factors for CI in multivariate analysis. Patients with PD-related peritonitis were significantly older ( p < 0.001) and more likely to have CI as defined by MoCA ( p = 0.035). After adjustment for age, however, CI was not a significant independent risk factor for PD-related peritonitis among self-care PD patients (OR 2.20, CI 0.65 – 7.44, p = 0.20). When we compared patients with MoCA-defined CI receiving self-care and assisted PD, there were no statistically significant differences between the 2 groups in terms of age, MoCA scores, or comorbidities. There were also no statistically significant differences in 1-year outcome of PD-related peritonitis rates or exit-site infections. Conclusion Cognitive impairment is common among local PD patients. Even with CI, peritonitis rate in self-care PD with adequate training is similar to CI patients on assisted PD.
Microelectronics/Packagingin the Defense Industry:Importance of SWaP-Cand Other Factors
Authors: Wiewiora Lee 
Published: December 2015

The modern battlefield demands that soldiers endure rough terrain and weather while carrying all necessary items for their mission. These necessities include their food, water, ammunition and mission essentials, typically electronics. In order to give the troops the most capability while in the field, the efficiency and dependability of electronics is paramount. Key to the requirements definition for mission electronics is Size, Weight and Power - Cost, commonly known as the acronym SWAP-C. In addition to satisfying the SWAP-C requirements, all mission electronics need proven reliability since lives are at stake.
Major defense systems in the past have lasted 30+ years. With this in mind, systems for tomorrow are being designed to support the defense industry's need for reliability, longevity and upgrade compatibility. This talk will focus on SWAP-C and high reliability in electronics and packaging to support the defense industry for years to come.
Sensor Integration Technologies for Internet of Things
Authors: Schrank Franz 
Published: December 2015

Internet of things (IoT) will influence all areas from consumer to health care to building and home automation and to observation. IoT enables direct communication between objects via internet. The main functional blocks of IoT devices are sensing, data transmitting, processing and analysis and subsequent actuation. As a result such a system will consist of sensors, actuators, wireless connection, data processing, power management, energy harvesting, memory and software. A total market volume of almost 400 Bio US$ is predicted for 2024 whereof about 12Bio US$ are expected for IoT sensors (Yole2014)). The main challenges are to reduce footprint (e.g. wearables, swarm), reduce costs of system, improve reliability and provide better performance. For example the costs of today's smart sensor systems are in the 100–1000US$ range and for 2024 an ASP in the 1US$ $ level is expected (Yole2014). To enable this, a high level of integration is needed for the next generations of IoT sensors. This will on one hand reduce costs and form factor but also enable multi sensors devices.
More than Moore integration of functions offers the potential to meet both performance and cost targets for mass-market adoption. In addition to SoC (System on Chip) and SiP (System in Package) heterogeneous 3D integrations will be key enablers. 3D integration with the main technology bricks like TSV (Through Silicon Via), RDL (Redistribution Layer), D2W (Die to Wafer) and W2W (Wafer to Wafer) stacking and embedding allows to combine different technologies - different CMOS notes, MEMS, photonics, etc. At the same time expensive single die packaging can be avoided.
The presentation will focus on reviewing 3D integration technologies and their potential for IoT from the perspective of a sensor solution provider.
New Discretization Methods for the Numerical Approximation of PDEs
Authors: Dahlke Stephan , Kutyniok Gitta , Stevenson Rob , Süli Endre 
Published: December 2015

The construction and mathematical analysis of numerical methods for PDEs is a fundamental area of modern applied mathematics. Among the various techniques that have been proposed in the past, some – in particular, finite element methods, – have been exceptionally successful in a range of applications. There are however a number of important challenges that remain, including the optimal adaptive finite element approximation of solutions to transport-dominated diffusion problems, the efficient numerical approximation of parametrized families of PDEs, and the efficient numerical approximation of high-dimensional partial differential equations (that arise from stochastic analysis and statistical physics, for example, in the form of a backward Kolmogorov equation, which, unlike its formal adjoint, the forward Kolmogorov equation, is not in divergence form, and therefore not directly amenable to finite element approximation, even when the spatial dimension is low). In recent years several original and conceptionally new ideas have emerged in order to tackle these open problems.
The goal of this workshop was to discuss and compare a number of novel approaches, to study their potential and applicability, and to formulate the strategic goals and directions of research in this field for the next five years.
Using a Team-Based Learning Approach at National Meetings to Teach Residents Genomic Pathology
Authors: Haspel Richard L. , Ali Asma M. , Huang Grace C. 
Published: December 2015

ABSTRACT

Background
Accumulating data suggest that team-based learning (TBL) is more effective than lecture-based teaching strategies. Educational sessions at national meetings, however, tend to be lecture-based, and unlike most examples of TBL, involve participants who do not know each other or the instructor.

Objective
We evaluated a 1-day TBL genomic pathology workshop for residents held at 3 national meetings.

Methods
A committee of experts developed the workshop. Prior to attending, participants were provided access to readings and asked to answer preparation questions. Each of the 4 modules within the workshop consisted of a 60-minute TBL activity flanked by 15- to 30-minute preactivity and postactivity lectures. We used surveys to acquire participant evaluation of the workshop.

Results
From 2013–2014, 86 pathology residents from 61 programs participated in 3 workshops at national meetings. All workshops were well received, with over 90% of attendees indicating that they would recommend them to other residents and that the material would help them as practicing pathologists. An incremental approach facilitated decreasing faculty presence at the workshops: the first 2 workshops had 7 faculty each (1 facilitator for each team and 1 circulating faculty member), while the final workshop involved only 2 faculty for 6 teams. For this final session, participants agreed that circulating faculty provided adequate support. Participant “buy-in” (requiring completion of a preworkshop survey) was critical in enabling a TBL approach.

Conclusions
These results demonstrate that TBL is a feasible and effective strategy for teaching genomic medicine that is acceptable to pathology residents at national meetings.
Weekly Training and Competitive Load of Junior Level Community Cricket Players
Authors: Talpey Scott William , Siesmaa Emma , White Peta , Finch Caroline F 
Published: December 2015

ABSTRACT

Purpose
Understanding the participation habits of junior cricket players is needed to better inform injury prevention strategies in this sporting population. This investigation sought to describe the amount of training and competition undertaken by junior community level cricket players in a typical week.

Materials and methods
A cross-sectional survey with a 1 week recall was administered to 281 Australian junior community club cricket players aged 9 to 16 years. The number of training and competitive matches in the previous week and the number of contexts competed or trained in during that same week were determined.

Results
The majority of the surveyed cricketers participated in. 1 match during the previous week, with 10% reporting having participated in. 2 matches. More players from the under 16 years (U16) level others competed in. 2 matches in the previous week. Coinciding with the greater number of weekly participations in the older age group, 49% (CI: 9.60) of the U16 players reported also taking part in. 2 training sessions in the previous week. Overall, more players aged under 12 years (U12) (46%; CI: 31.6.57.6) reported not attending any cricket training in the previous week, than did older age groups (7% each). Moreover, 28% of U16 players reported also competing in an adult competition.

Conclusion
Older players had greater training and competitive loads than younger players. The number of competitive contexts across which junior players compete also increased with age. There is potential for heightened injury risk when training and match loads get too high, especially across playing contexts.

How to cite this article
Talpey SW, Siesmaa E, White P, Finch CF. Weekly Training and Competitive Load of Junior Level Community Cricket Players. J Postgrad Med Edu Res 2015;49(4): 164-167.
Medical Coverage of Cricket Matches
Authors: Mansingh Akshai 
Published: December 2015

ABSTRACT
Cricket is played around the world, at all ages and grades. Medical coverage of cricket matches varies equally, depending on the location, grade of cricket, expertise and resources available. Whereas recommendations exist for International matches and tournaments, this may not even extend to first class matches in many countries. Few sports provide guidelines on minimum requirements of coverage of events, and none exist in cricket. This paper proposes minimum standards aimed at being appropriate for all regions and levels of cricket.

How to cite this article
Mansingh A. Medical Coverage of Cricket Matches. J Postgrad Med Edu Res 2015;49(4):182-185.