bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double‐Stranded Helical Oligomers Covalently Bridged by Rotary Cyclic Boronate Esters
Authors: Iida Hiroki , Ohmura Kenji , Noda Ryuta , Iwahana Soichiro , Katagiri Hiroshi , Ousaka Naoki , Hayashi Taku , Hijikata Yuh , Irle Stephan , Yashima Eiji 
Published: February 2017

AbstractNovel double helices covalently bridged by cyclic boronate esters were synthesized from complementary dimers with an m‐terphenyl backbone joined by a chiral or achiral phenylene linker bearing diethyl boronates and diols, respectively. The X‐ray crystallographic analysis and variable‐temperature NMR and circular dichroism measurements, along with theoretical calculations, revealed that the double helices function as a “molecular rotor” in which the cyclic boronate ester units rotate, yielding two stable rotamers at low temperatures. Moreover, our data indicates that the covalently bonded double helices can undergo a unique helix‐inversion simultaneously with a rotational motion of the boronate esters.
EliteTree™: an advanced biomass tree crop technology that features greater wood density and accelerated stem growth
Authors: Ko Jae‐Heung , Kim Won‐Chan , Cho Jin‐Seong , Choi Young‐Im , Park Eung‐Jun , Im Jong Hee , Han Okran , Keathley Daniel , Han Kyung‐Hwan 
Published: February 2017

AbstractDue to wood's potential for large‐scale commercial production of biofuels, a rapid increase in the use of wood as a source of energy is expected as policies promoting greater use of renewable energy are adopted globally. However, the economics of purpose‐grown tree feedstocks for energy show that these production systems are not financially viable without improvement in the base growth rate. Conventional breeding programs have produced willow and poplar clones that show potential for rapid growth, but current top‐performing clones do not grow fast enough for profitable biofuel production. Genetic manipulation of secondary wall biosynthesis is the most direct path to resolving this growth barrier. To that end, we developed an innovative biomass tree crop technology, EliteTree™, that results in greater wood density and accelerated growth of stems. This technology is built on overexpression of Gibberellin 20‐oxidase to increase plant stem growth in both height and diameter and increase lignocellulosic biomass accumulation through overexpression of the transcription factor MYB46, which is a master regulator for secondary wall biosynthesis. EliteTree™ technology uses 2A‐mediated bicistronic gene expression, with our proprietary utility promoter DX15, such that the genetic manipulation is limited to wood tissue, yielding transgenic poplars with xylem‐specific co‐expression of MYB46 and PdGA20ox1. The development of faster growing elite tree genotypes with increased wood density and growth rates will pave the way for truly sustainable and economically viable bioenergy/biofuel production using short rotation tree plantations, and ultimately will lessen carbon emissions and has the potential to revitalize rural economies. © 2017 Society of Chemical Industry and John Wiley & Sons, Ltd
European Society of Endocrine Surgeons (ESES) and European Network for the Study of Adrenal Tumours (ENSAT) recommendations for the surgical management of adrenocortical carcinoma
Authors: Gaujoux S , Mihai R , Carnaille B , Dousset B , Fiori C , Porpiglia F , Hellman P , Iacobone M , Kraimps J-L , Donatini G , Langenhuijsen J , Lorenz K , Mathonnet M , Mirallié E , Blanchard C , van Dijkum E Nieveen , Raffaelli M , Rayes N , Sébag F , Triponez F , Valeri A , Waldmann J , Zinzindohoue F 
Published: February 2017

Abstract

Background
Radical surgery provides the best chance of cure for adrenocortical carcinoma (ACC), but perioperative surgical care for these patients is yet to be standardized.

Methods
A working group appointed jointly by ENSAT and ESES used Delphi methodology to produce evidence-based recommendations for the perioperative surgical care of patients with ACC. Papers were retrieved from electronic databases. Evidence and recommendations were classified according to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system, and were discussed until consensus was reached within the group.

Results
Twenty-five recommendations for the perioperative surgical care of patients with ACC were formulated. The quality of evidence is low owing to the rarity of the disease and the lack of prospective surgical trials. Multi-institutional prospective cohort studies and prospective RCTs are urgently needed and should be strongly encouraged.

Conclusion
The present evidence-based recommendations provide comprehensive advice on the optimal perioperative care for patients undergoing surgery for ACC.
Randomized clinical trial of comprehensive geriatric assessment and optimization in vascular surgery
Authors: Partridge J S L , Harari D , Martin F C , Peacock J L , Bell R , Mohammed A , Dhesi J K 
Published: February 2017

Abstract

Background
Increasing numbers of older patients are undergoing vascular surgery. Inadequate preoperative assessment and optimization may contribute to increased postoperative morbidity and mortality.

Methods
Patients aged at least 65 years scheduled for elective aortic aneurysm repair or lower-limb arterial surgery were enrolled in an RCT of standard preoperative assessment or preoperative comprehensive geriatric assessment and optimization. Randomization was stratified by sex and surgical site (aorta/lower limb). Primary outcome was length of hospital stay. Secondary outcome measures included new medical co-morbidities, postoperative medical or surgical complications, discharge to a higher level of dependency and 30-day readmission rate.

Results
A total of 176 patients were included in the final analysis (control 91, intervention 85). Geometric mean length of stay was 5·53 days in the control group and 3·32 days in the intervention group (ratio of geometric means 0·60, 95 per cent c.i. 0·46 to 0·79; P &lt; 0·001). There was a lower incidence of delirium (11 versus 24 per cent; P = 0·018), cardiac complications (8 versus 27 per cent; P = 0·001) and bladder/bowel complications (33 versus 55 per cent; P = 0·003) in the intervention group compared with the control group. Patients in the intervention group were less likely to require discharge to a higher level of dependency (4 of 85 versus 12 of 91; P = 0·051).

Conclusion
In this study of patients aged 65 years or older undergoing vascular surgery, preoperative comprehensive geriatric assessment was associated with a shorter length of hospital stay. Patients undergoing assessment and optimization had a lower incidence of complications and were less likely to be discharged to a higher level of dependency. Registration number: ISRCTN23142588 (http://www.controlled-trials.com).
BRAF‐V600E immunohistochemistry in a large series of glial and glial–neuronal tumors
Authors: Breton Quentin , Plouhinec Hélène , Prunier‐Mirebeau Delphine , Boisselier Blandine , Michalak Sophie , Menei Philippe , Rousseau Audrey 
Published: February 2017

AbstractIntroductionSome glial–neuronal tumors (GNT) (pleomorphic xantho‐astrocytoma [PXA], ganglioglioma [GG]) display BRAF‐V600E mutation, which represents a diagnostic clue to these entities. Targeted therapies against BRAF‐V600 protein have shown promising results in GNT. The aim of this study was to assess the utility of BRAF‐V600E immunohistochemistry (IHC, clone VE1) in daily practice in a series of 140 glial, and GNT compared to molecular biology (MB) techniques.MethodsWe performed BRAF‐V600E IHC on all 140 cases. We used Sanger sequencing and allele‐specific quantitative PCR (ASQ‐PCR) to detect BRAF‐V600E mutation when sufficient amount of materiel was available.ResultsBRAF‐V600E immunostaining was detected in 29.5% of cases (41/140 cases; 61.5% GG/GC/AGG (32/52), 33% PXA, 6.6% pilocytic astrocytomas). In 47 cases, MB could be performed: Sanger sequencing and ASQ‐PCR in 34 cases, ASQ‐PCR only in 11 cases, and Sanger sequencing only in two cases. In initial tumors, Sanger sequencing identified BRAF‐V600E mutation in 19.5% tumors (seven of 36 tested cases). ASQ‐PCR showed mutation in 48.5% tumors (17/35 tested cases). In six cases (5 GG, one PXA), the results were discordant between IHC and MB; the five GG cases were immunopositive for BRAF‐V600E but wild type with both MB techniques. In another 7 GG, the percentage of mutated (ganglion) cells was low, and Sanger sequencing failed to detect the mutation, which was detected by IHC and ASQ‐PCR.ConclusionsIn tumors with few mutated cells (e.g., GG), anti‐BRAF‐V600E IHC appears more sensitive than Sanger sequencing. The latter, although considered as the gold standard, is not to be used up‐front to detect BRAF mutation in GG. The combination of IHC and ASQ‐PCR appears more efficient to appraise the indication of targeted therapies in these glioneuronal tumors.
Calcium‐Independent Activation of an Allosteric Network in Langerin by Heparin Oligosaccharides
Authors: Hanske Jonas , Wawrzinek Robert , Geissner Andreas , Wamhoff Eike‐Christian , Sellrie Katrin , Schmidt Henrik , Seeberger Peter H. , Rademacher Christoph 
Published: February 2017

AbstractThe C‐type lectin receptor Langerin is a glycan‐binding protein that serves as an uptake receptor on Langerhans cells and is essential for the formation of Birbeck granules. Whereas most Langerin ligands are recognized by a canonical Ca2+‐dependent binding site, heparins have been proposed to make additional contacts to a secondary, Ca2+‐independent site. Glycan array screening and biomolecular NMR spectroscopy were employed to investigate the molecular mechanism of these interactions. We observed that binding of heparin hexasaccharides to a secondary site did not require the presence of Ca2+ and activated a previously identified intradomain allosteric network of Langerin (thus far only associated with Ca2+ affinity and release). We propose a communication hub between these two binding sites, which sheds new light on modulatory functions of Langerin–heparin interactions.
Propofol protects against hepatic ischemia/reperfusion injury via miR‐133a‐5p regulating the expression of MAPK6
Authors: Hao Wei , Zhao Zhi‐Hui , Meng Qing‐Tao , Tie Mu‐Er , Lei Shao‐Qing , Xia Zhong‐Yuan 
Published: February 2017

AbstractPropofol has been found to play an important role in hepatic ischemia/reperfusion (I/R) injury with the antioxidant effects. However, the molecular mechanism of propofol in hepatic I/R injury has not been fully understood. Male Sprague–Dawley rats were randomly assigned into Sham group, hepatic I/R group, and propofol treatment group. I/R injury was attained by ischemia for 1 h and reperfusion for 2 h. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity were detected. QSG‐7701 cells were cultured in hypoxia condition for 15 h and then in reoxygenation condition for 6 h to imitate hypoxia/reoxygenation (H/R) injury in vitro. Real‐time RT‐PCR and Western blot were performed to determine the expression of miR‐133a‐5p and MAPK6. Luciferase reporter assay was used to determine the regulation of miR‐133a‐5p on MAPK6. Propofol significantly reduced the activities of serum AST and ALT induced by hepatic I/R injury in rats. Propofol increased the level of miR‐133a‐5p and decreased the expression of MAPK6 in vivo and in vitro. Luciferase reporter assay showed that MAPK6 was a target of miR‐133a‐5p. Knockdown of miR‐133a‐5p abrogated the effect of propofol on the upregulation of MAPK6 induced by H/R. MAPK6 overexpression promoted the cell apoptosis induced by H/R which could be attenuated by propofol. Finally, we found that miR‐133a‐5p reversed the protective effect of propofol in rats with hepatic I/R injury. Propofol showed protective roles for hepatic I/R injury in vivo and H/R injury in vitro, which involved with miR‐133a‐5p regulating the expression of MAPK6.
Radiation dose benchmarks in pediatric cardiac catheterization: A prospective multi‐center C3PO‐QI study
Authors: Cevallos Priscila C. , Armstrong Aimee K. , Glatz Andrew C. , Goldstein Bryan H. , Gudausky Todd M. , Leahy Ryan A. , Petit Christopher J. , Shahanavaz Shabana , Trucco Sara M. , Bergersen Lisa J. 
Published: February 2017

ObjectivesThis study sought to update benchmark values to use a quality measure prospectively.BackgroundCongenital Cardiac Catheterization Outcomes Project – Quality Improvement (C3PO‐QI), a multi‐center registry, defined initial radiation dose benchmarks retrospectively across common interventional procedures. These data facilitated a dose metric endorsed by the American College of Cardiology in 2014.MethodsData was collected prospectively by 9 C3PO‐QI institutions with complete case capture between 1/1/2014 and 6/30/2015. Radiation was measured in total air kerma (mGy), dose area product (DAP) (µGy*M2), DAP per body weight, and fluoroscopy time (min), and reported by age group as median, 75th and 95th%ile for the following six interventional procedures: (1) atrial septal defect closure; (2) aortic valvuloplasty; (3) treatment of coarctation of the aorta; (4) patent ductus arteriosus closure; (5) pulmonary valvuloplasty; and (6) transcatheter pulmonary valve implantation.ResultsThe study was comprised of 1,680 unique cases meeting inclusion criteria. Radiation doses were lowest for pulmonary valvuloplasty (age <1 yrs, median mGy: 59, DAP: 249) and highest in transcatheter pulmonary valve implantation (age >15 yrs, median mGy: 1835, DAP: 17990). DAP/kg standardized outcome measures across weights within an age group and procedure type significantly more than DAP alone. Radiation doses decreased for all procedures compared to those reported previously by both median and median weight‐based percentile curves. These differences in radiation exposure were observed without changes in median fluoroscopy time.ConclusionsThis study updates previously established benchmarks to reflect QI efforts over time. These thresholds can be applied for quality measurement and comparison. © 2017 Wiley Periodicals, Inc.
22q11.2 microduplication syndrome with associated esophageal atresia/tracheo‐esophageal fistula and vascular ring
Authors: Nguyen Linda T. , Fleishman Rachel , Flynn Emilee , Prasad Rajeev , Moulick Achintya , Mesia Cesar Igor , Moyer Sue , Jethva Reena 
Published: February 2017

Key Clinical MessageThis case report describes a patient with a 22q11.2 duplication. His features, which include VACTERL association with an esophageal atresia/tracheo‐esophageal fistula and a vascular ring, expand the previously described phenotype for this duplication.
Sensitive Detection of Hg2+ with Switchable Electrochemiluminescence Luminophore and Disposable Bipolar Electrode
Authors: Liu Hongxing , Zhou Xiaoming , Shen Jinjin , Xing Da 
Published: February 2017

AbstractA novel paper‐based bipolar electrode‐electrochemiluminescence (pBPE‐ECL) switch system was used for the rapid, label‐free, and sensitive detection of Hg2+. In the proposed approach, Hg2+ selectively mediates two thymine‐enriched single‐stranded DNA probes to form double‐stranded DNA (dsDNA). In the presence of Hg2+, the “light‐switch” molecule [Ru(phen)2dppz]2+ can freely intercalate into the base pairs of the dsDNA, resulting in intense ECL emission. The assay takes advantage of the wireless pBPE‐ECL platform to yield a low‐cost, disposable, and sensitive analysis. The system has a limit of 0.1 nM for Hg2+ detection. We also showed that the system can be used to distinguish Hg2+ over other metal ions, including Pb2+, Zn2+, Cu2+, Ba2+, Co2+, Cd2+, Fe3+, Mn2+, and Li+. Moreover, the proposed approach was rapid, low‐cost, and label‐free for effective sensing of Hg2+ in drinking and lake water.
Do CH–Anion and Anion–π Interactions Alter the Mechanism of 2:1 Host–Guest Complexation in Arylethynyl Monourea Anion Receptors?
Authors: Eytel Lisa M. , Gilbert Annie K. , Görner Paul , Zakharov Lev N. , Johnson Darren W. , Haley Michael M. 
Published: February 2017

AbstractSelective tuning of arylethynyl urea scaffolds for anionic guests requires an understanding of preferred binding motifs of the host–guest interaction. To investigate the binding preference of receptors without a pre‐organized binding pocket, two electron‐deficient phenylacetylene receptors with a single urea moiety have been prepared and were found to bind halides as 2:1 host–guest complexes that feature key CH–anion or anion–π interactions. These supporting interactions also appear to influence the mechanism of the 2:1 binding event.
Anti‐Inflammatory Oxicams as Multi‐donor Ligand Systems: pH‐ and Solvent‐Dependent Coordination Modes of Meloxicam and Piroxicam to Ru and Os
Authors: Aman Farhana , Hanif Muhammad , Kubanik Mario , Ashraf Adnan , Söhnel Tilo , Jamieson Stephen M. F. , Siddiqui Waseeq Ahmad , Hartinger Christian G. 
Published: February 2017

AbstractThe nitrogen‐ and sulfur‐containing 1,2‐benzothiazines meloxicam and piroxicam are widely used as nonsteroidal anti‐inflammatory drugs. Intrigued by the presence of multiple donor atoms and therefore potentially rich coordination chemistry, we prepared a series of organometallic Ru and Os compounds with meloxicam and piroxicam featuring either as mono‐ or bidentate ligand systems. The choice of the solvent and the pH value was identified as the critical parameter to achieve selectively mono‐ or bidentate coordination. The coordination modes were confirmed experimentally by NMR spectroscopy and single crystal X‐ray diffraction analysis. Using DFT calculations, it was established that complexes in which meloxicam acts as a bidentate N,O donor are energetically more favorable than coordination as O,O and S,O donor systems. Since meloxicam and piroxicam derivatives have shown anticancer activity in the past, we aimed to compare the complexes with mono‐ and bidentate ligands on their in vitro anticancer activity. However, stability studies revealed that only the latter complexes were stable in [D6]DMSO/D2O (5:95) and therefore no direct comparisons could be made. The meloxicam complexes 1 and 2 showed moderate cytotoxicity, whereas the piroxicam derivatives 5 and 6 were hardly active against the utilized cell lines.
A New Strategy to Design Highly Sustainable Sulfide PhotoCatalyst for Hydrogen Production
Authors: Wang Lu , Wang Wenzhong 
Published: February 2017

AbstractA new strategy has been developed to design sulfides photocatalysts with superior stability without any noble metal deposition. The as‐designed Ag8SnS6 showed capability of steadily evolving hydrogen for at least 400 h without any deactivation and the turnover number is as high as 95.8.
Mutual Absolute Continuity of Interior and Exterior Harmonic Measure Implies Rectifiability
Authors: Azzam Jonas , Mourgoglou Mihalis , Tolsa Xavier 
Published: February 2017

AbstractWe show that, for disjoint domains in the euclidean space whose boundaries satisfy a nondegeneracy condition, mutual absolute continuity of their harmonic measures implies absolute continuity with respect to surface measure and rectifiability in the intersection of their boundaries. © 2017 Wiley Periodicals, Inc.
Synthesis of Magnetic Nanoparticles by Ultrashort Pulsed Laser Ablation of Iron in Different Liquids
Authors: Kanitz Alexander , Hoppius Jan S. , del Mar Sanz María , Maicas Marco , Ostendorf Andreas , Gurevich Evgeny L. 
Published: February 2017

AbstractMagnetic nanoparticles were generated by ultrashort pulsed laser ablation of an iron target in water, methanol, ethanol, acetone and toluene. The relationship between ablation rate, liquid properties and the physical and chemical properties of the nanoparticles was studied. Composition, morphology and magnetic properties were investigated by TEM, XPS and vibrating‐sample (VSM) and SQUID magnetometry. The properties of the generated nanoparticle ensembles reflected the influence of the liquid environment on the particle formation process. For example, the composition was strongly dependent on the carbon to oxygen ratio within the molecules of the liquid. In contrast to short pulsed laser ablation in liquids, the nanoparticles generated by ultrashort pulses had a higher level of polycrystallinity.
Characterization of a Dinuclear Copper(II) Complex and Its Fleeting Mixed‐Valent Copper(II)/Copper(III) Counterpart
Authors: Kochem Amélie , Gennarini Federica , Yemloul Mehdi , Orio Maylis , Le Poul Nicolas , Rivière Eric , Giorgi Michel , Faure Bruno , Le Mest Yves , Réglier Marius , Simaan A. Jalila 
Published: February 2017

AbstractThe synthesis of a dinuclear copper(II) complex, supported by a 1,3‐diamino‐2‐propanol‐based tetraamide ligand, is reported. Structural properties in the solid state and in solution, by means of XRD analysis and NMR spectroscopy, respectively, provide evidence of a highly flexible complex that can display several conformations, leading to the image of the wings of a butterfly. The complex was fully characterized and the redox properties were investigated. Room‐temperature spectro‐electrochemistry was used to monitor the formation of a metastable mono‐oxidized product that displayed an absorption band centered at λ=463 nm. EPR investigation of the low‐temperature, chemically generated, mono‐oxidized product reveals the presence of an intermediate described as a mixed‐valent CuIICuIII species, which is a model of the possible highly oxidizing intermediate in particulate methane monooxygenase.
A Versatile Approach for In Situ Monitoring of Photoswitches and Photopolymerizations
Authors: Dolinski Neil D. , Page Zachariah A. , Eisenreich Fabian , Niu Jia , Hecht Stefan , Read de Alaniz Javier , Hawker Craig J. 
Published: February 2017

AbstractA simple, inexpensive, and modular method to directly illuminate NMR samples for in situ analysis of photochemical transformations is reported. The versatility of this technique is demonstrated by analyzing the light‐induced propagating front for small‐molecule photoswitches and the kinetics of photocontrolled living radical polymerizations. In situ measurements allow oxygen‐sensitive and rapid photoevents to be studied in detail, leading to reliable determination of photoswitching quantum yields and polymerization rates. By systematically tuning light intensity, a direct relationship between propagation rate and intensity is revealed. Of particular note is the facile translation of the conditions identified through this NMR analysis to analogous benchtop experiments with insight into the nature of the photoreactive species.
Electrochemical Behavior of PEDOT/Lignin in Ionic Liquid Electrolytes: Suitable Cathode/Electrolyte System for Sodium Batteries
Authors: Casado Nerea , Hilder Matthias , Pozo‐Gonzalo Cristina , Forsyth Maria , Mecerreyes David 
Published: February 2017

AbstractBiomass‐derived polymers, such as lignin, contain quinone/ hydroquinone redox moieties that can be used to store charge. Composites based on the biopolymer lignin and several conjugated polymers have shown good charge‐storage properties. However, their performance has been only studied in acidic aqueous media limiting their applications mainly to supercapacitors. Here, we show that PEDOT/lignin (PEDOT: poly(3,4‐ethylenedioxythiophene)) biopolymers are electroactive in aprotic ionic liquids (ILs) and we move a step further by assembling sodium full cell batteries using PEDOT/lignin as electrode material and IL electrolytes. Thus, the electrochemical activity and cycling of PEDOT/lignin electrodes was investigated in 1‐butyl‐1‐methylpyrrolidinium bis(trifluoromethylsulfonyl)imide (BMPyrTFSI), 1‐butyl‐1‐methylpyrrolidinium bis(fluorosulfonyl)imide (BMPyrFSI), 1‐ethyl‐3‐methylimidazolium bis(trifluoromethylsulfonyl)imide (EMImTFSI) and 1‐ethyl‐3‐methylimidazolium bis(fluorosulfonyl)imide (EMImFSI) IL electrolytes. The effects of water and sodium salt addition to the ILs were investigated to obtain optimum electrolyte systems for sodium batteries. Finally, sodium batteries based on PEDOT/lignin cathode with imidazolium‐based IL electrolyte showed higher capacity values than pyrrolidinium ones, reaching 70 mAhg−1. Our results demonstrate that PEDOT/lignin composites can serve as low cost and sustainable cathode materials for sodium batteries.