bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quartz–coesite–stishovite relations in shocked metaquartzites from the Vredefort impact structure, South Africa
Authors: Spray John G. , Boonsue Suporn 
Published: November 2017

AbstractCoesite and stishovite are developed in shock veins within metaquartzites beyond a radius of ~30 km from the center of the 2.02 Ga Vredefort impact structure. This work focuses on deploying analytical field emission scanning electron microscopy, electron backscattered diffraction, and Raman spectrometry to better understand the temporal and spatial relations of these silica polymorphs. α‐Quartz in the host metaquartzites, away from shock veins, exhibits planar features, Brazil twins, and decorated planar deformation features, indicating a primary (bulk) shock loading of >5 < 35 GPa. Within the shock veins, coesite forms anhedral grains, ranging in size from 0.5 to 4 μm, with an average of 1.25 μm. It occurs in clasts, where it displays a distinct jigsaw texture, indicative of partial reversion to a less dense SiO2 phase, now represented by microcrystalline quartz. It is also developed in the matrix of the shock veins, where it is typically of smaller size (<1 μm). Stishovite occurs as euhedral acicular crystals, typically <0.5 μm wide and up to 15 μm in length, associated with clast–matrix or shock vein margin–matrix interfaces. In this context, the needles occur as radiating or subparallel clusters, which grow into/over both coesite and what is now microcrystalline quartz. Stishovite also occurs as more blebby, subhedral to anhedral grains in the vein matrix (typically <1 μm). We propose a model for the evolution of the veins (1) precursory frictional melting in a microfault (~1 mm wide) generates a molten matrix containing quartz clasts. This is followed by (2) arrival of the main shock front, which shocks to 35 GPa. This generates coesite in the clasts and in the matrix. (3) On initial shock release, the coesite partly reverts to a less dense SiO2 phase, which is now represented by microcrystalline quartz. (4) With continued release, stishovite forms euhedral needle clusters at solid–liquid interfaces and as anhedral crystals in the matrix. (5) With decreasing pressure–temperature, the matrix completes crystallization to yield a microcrystalline quasi‐igneous texture comprising quartz–coesite–stishovite–kyanite–biotite–alkali feldspar and accessory phases. It is possible that the shock vein represents the locus of a thermal spike within the bulk shock, in which case there is no requirement for additional pressure (i.e., the bulk shock was ≃35 GPa). However, if that pressure was not realized from the main shock, then supplementary pressure excursions within the vein would have been required. These could have taken the form of localized reverberations from wave trapping, or implosion processes, including pore collapse, phase change–initiated volume reduction, and melt cavitation.
Chemical and mineralogical characterization of the Mineo (Sicily, Italy) pallasite: A unique sample
Authors: Zucchini A. , Petrelli M. , Frondini F. , Petrone C. M. , Sassi P. , Di Michele A. , Palmerini S. , Trippella O. , Busso M. 
Published: November 2017

AbstractThe Mineo pallasite is characterized here for the first time. The only 42 g still available worldwide is part of the collection of the Department of Physics and Geology, University of Perugia. A multianalytical approach was used, joining field‐emission scanning electron microscopy, Raman analysis, X‐ray powder diffraction, electron‐probe microanalysis, and laser ablation inductively coupled plasma mass spectrometry. Results highlighted that (1) the Mineo pallasite belongs to the Main Group pallasites; (2) the silicate component is essentially olivine, with no pyroxene component; (3) the olivine chemical composition varies in terms of both iron and trace elements; (4) the metal phase is essentially kamacite with the taenite mainly found in the plessite structure; (5) phosphide phases are present as schreibersite and barringerite. The observed compositional variability in olivines as well as their occurrence as both angular and rounded crystals suggest that the Mineo pallasite could have been derived from a large impact of a differentiated parent body with a larger solid body. The resulting pallasite conglomerate consists of the compositionally different olivines, likely coming from different areas of the same differentiated parent body, and the residual molten Fe‐Ni.
Acute kidney injury with consumption of raw gall bladder of Indian carp fish (Labeo rohita): A single center study from India
Authors: Krishna Amresh , Singh Prit P , Vardhan Harsh , Kumar Om , Prasad Govind 
Published: November 2017

ABSTRACTAimThis retrospective study examined the clinical presentation and outcome of all patients who presented with acute kidney injury (AKI) following consumption of uncooked fish gallbladder as folk medicine.MethodsWe reviewed all cases admitted at our institute between 1 January 1997 and 31 December 2016 following ingestion of fish gallbladder (Indian carp/Labeo rohita).ResultsA total 32 of patients were included, with a male: female ratio of 3:1 and mean age 44.34 ± 13.33 years. The mean number of gall bladder consumed was 4.59 ± 4.75. All 32 patients presented with hepatic and renal failure. The mean duration of onset of symptoms following ingestion was 6.47 ± 2.84 h. At the time of admission, urine output was 187.9 ± 141 mL/24 h, serum creatinine 11.66 ± 2.50 mg/dL, serum bilirubin 6.14 ± 3.91 mg/dL, serum glutamate‐pyruvate transaminase (SGPT) 687 ± 458 IU/L and serum glutamic oxaloacetic transaminase (SGOT) 188 ± 181 IU/L. All but one patient required haemodialysis. Twenty‐seven patients were discharged with recovering acute kidney injury while five patients died. Mean duration of hospital stay was 12.94 ± 8.31 days. Mean number of haemodialysis sessions received by patients was 4.59 ± 3.12. Interval between consumption and onset of symptoms, serum bilirubin and SGPT were found to be significantly different between those who survived and died.ConclusionAcute kidney injury associated with ingestion of raw fish gallbladder is associated with significant morbidity and mortality.
Acid hydrolysis reveals a low but constant level of pheomelanin in human black to brown hair
Authors: Ito Shosuke , Miyake Shiho , Maruyama Shoji , Suzuki Itaru , Commo Stéphane , Nakanishi Yukiko , Wakamatsu Kazumasa 
Published: November 2017

SummaryWe previously reported a constant ratio of the benzothiazole pheomelanin marker thiazole‐2,4,5‐tricarboxylic acid (TTCA) to the eumelanin marker pyrrole‐2,3,5‐tricarboxylic acid (PTCA) in eumelanic, black human hair. A constant level (20%–25%) of benzothiazole‐type pheomelanin was recently demonstrated in human skin with varying concentrations of melanin. Therefore, in this study, we aimed to investigate the origin of pheomelanin markers in black to brown human hair by developing a method to remove protein components from hair by heating with 6 M HCl at 110°C for 16 hr. For comparison, synthetic melanins were prepared by oxidizing mixtures of varying ratios of dopa and cysteine with tyrosinase. Hair melanins and synthetic melanins were subjected to acid hydrolysis followed by alkaline H2O2 oxidation. The results show that the hydrolysis leads to decarboxylation of the 5,6‐di‐hydroxyindole‐2‐carboxylic acid moiety in eumelanin and the benzothiazole moiety in pheomelanin and that eumelanic human hair contains 11%–17% benzothiazole‐type pheomelanin.
Metastasis‐specific patterns of response and progression with anti‐PD‐1 treatment in metastatic melanoma
Authors: Lee Jenny H. J. , Lyle Megan , Menzies Alexander M. , Chan Matthew M. K. , Lo Serigne , Clements Arthur , Carlino Matteo S. , Kefford Richard F. , Long Georgina V. 
Published: November 2017

SummaryThis study evaluated patterns of response as discerned by comprehensive metastasis‐specific analysis in metastatic melanoma patients receiving anti‐PD‐1 antibodies. Bi‐dimensional measurements of every metastasis in patients enrolled in the KEYNOTE‐001 trial at a single institution were obtained at baseline and throughout treatment. Twenty‐seven evaluable patients had 399 baseline metastases measurable on CT imaging. Complete response (CR) which occurred in 52.6% of metastases was smaller (mean 223 mm2 versus 760 mm2, p < .01) and occurred more frequently in the lungs (65% versus 39.4%, p < .01). Response was heterogenous (new/progressing metastases alongside CR metastases) at first assessment in 4/14 patients with objective response (OR) as opposed to 7/13 patients with non‐OR. CR of individual metastases is common and influenced by site and size. Most patients with OR demonstrate homogenous regression in all metastases at the first assessment. In contrast, patients with early heterogeneity had a poor outcome.
Regulation of cell proliferation in the retinal pigment epithelium: Differential regulation of the death‐associated protein like‐1 DAPL1 by alternative MITF splice forms
Authors: Ma Xiaoyin , Hua Jiajia , Zheng Guoxiao , Li Fang , Rao Chunbao , Li Huirong , Wang Jing , Pan Li , Hou Ling 
Published: November 2017

SummaryVertebrate eye development and homoeostasis critically depend on the regulation of proliferation of cells forming the retinal pigment epithelium (RPE). Previous results indicated that the death‐associated protein like‐1 DAPL1 cell autonomously suppresses RPE proliferation in vivo and in vitro. Here, we show in human RPE cell lines that the pigment cell transcription factor MITF regulates RPE cell proliferation by upregulating DAPL1 expression. DAPL1 regulation by MITF is, however, mediated predominantly by (−) MITF, one of two alternative splice isoforms of MITF that lacks six residues located upstream of the DNA‐binding basic domain. Furthermore, we find that the regulation of DAPL1 by MITF is indirect in that (−) MITF stimulates the transcription of Musashi homolog‐2 (MSI2), which negatively regulates the processing of the anti‐DAPL1 microRNA miR‐7. Our results provide molecular insights into the regulation of RPE cell proliferation and quiescence and may help us understand the mechanisms of normal RPE maintenance and of eye diseases associated with either RPE hyperproliferation or the lack of regenerative proliferation.
Schistosoma mansoni‐specific immune responses and allergy in Uganda
Authors: Nkurunungi G. , Kabagenyi J. , Nampijja M. , Sanya R. E. , Walusimbi B. , Nassuuna J. , Webb E. L. , Elliott A. M. ,   the LaVIISWA study team
Published: November 2017

SummaryLow allergy‐related disease (ARD) prevalence in low‐income countries may be partly attributed to helminth infections. In the Schistosoma mansoni (Sm)‐endemic Lake Victoria islands (Uganda), we recently observed positive helminth‐allergy associations, despite low ARD prevalence. To understand how Sm‐induced cytokine and antibody profiles might influence allergic response profiles in this population, we assessed Schistosoma worm (SWA)‐ and egg antigen (SEA)‐specific Th1 (IFN‐γ), Th2 (IL‐5, IL‐13) and regulatory (IL‐10) cytokine profiles (n = 407), and total (n = 471), SWA‐, SEA‐ and allergen (house dust mite [HDM] and cockroach)‐specific (as)IgE and IgG4 profiles (n = 2117) by ELISA. Wheeze was inversely associated with SWA‐specific IFN‐γ (P < .001) and IL‐10 (P = .058), and SEA‐specific IL‐5 (P = .004). Conversely, having a detectable asIgE response was positively associated with SWA‐specific IL‐5 (P = .006) and IL‐10 (P < .001). Total, SWA‐, SEA‐ and allergen‐specific IgE and IgG4 responses were higher among Sm Kato‐Katz positive (SmKK+) and skin prick test (SPT)+ individuals compared to SmKK‐ and SPT‐ individuals. However, total and asIgG4/IgE ratios were lower among SPT+ and wheezing individuals. We conclude that, in this population, helminth‐induced antibody and cytokine responses may underlie individual positive helminth‐atopy associations, while the overall IgG4‐IgE balance may contribute to the low overall prevalence of clinical allergies in such settings.
Can labor provisions in trade agreements promote gender equality? Empirical evidence from Cambodia
Authors: López Mourelo Elva , Samaan Daniel 
Published: November 2017

AbstractIn recent years, an increasing number of regional and bilateral trade agreements have emerged that include provisions on labor standards. The claimed purpose of these labor provisions is to improve working conditions in developing and emerging economies. However, little is known about whether such provisions actually do impact working conditions. This paper conducts an econometric study on the effectiveness of labor provisions in trade agreements. In particular, we evaluate the impact of the 1999 Bilateral Textile Agreement between Cambodia and the United States (CUSBTA) on both the gender wage gap and discrimination. The agreement combined the incentive of higher exports with the obligation of textile manufacturers to comply with international core labor standards, which include the elimination of discrimination in respect of employment and occupation. Using data from the Cambodia Socioeconomic Survey and applying a difference‐in‐difference estimation, we find a statistically significant reduction of the gender wage gap in the textile sector that can be attributed to the CUSBTA.
Warm white LED lighting in museums: Ageing effects on terpenoid resins assessed through Raman spectroscopy and chemometrics
Authors: Osticioli I. , Ciofini D. , Mencaglia A. A. , Siano S. 
Published: November 2017

AbstractIn this work, warm white (3,000 K) LEDs were used for investigating accelerated ageing of different classes of natural terpenoid compounds. In particular, colophony, sandarac, shellac, and mastic resins were considered. Maximum total irradiance of 80 Mlxh was used, which can be compared to about 130 years of exposure in recommended museum conditions. Moreover, another set of the same resins was kept in darkness conditions in order to assess kinetic differences. Raman spectroscopy was employed to assess molecular changes occurring in resins structures during both dark and light ageing. Spectroscopic information was achieved through a portable Raman scanner provided with a narrow‐band CW diode‐pumped Nd:YAG (1,064 nm) laser and an NIR spectrometer equipped with an InGaAs linear array. Vis‐LED light appears to be suitable to avoid yellowing in the case of mastic and colophony resins suggesting that it is advisable to use this light with respect to traditional halogen lamps for illuminating museums and art galleries. Conversely, the ageing process of sandarac and shellac appears not to be particularly affected by the UV radiation. Raman spectroscopy in combination with multivariate analysis (principal component analysis) was able to provide information about the ageing process of colophony both in light and dark conditions.
Time and motion studies of National Health Service cataract theatre lists to determine strategies to improve efficiency
Authors: Roberts Harry W , Myerscough James , Borsci Simone , Ni Melody , O’Brart David P S 
Published: November 2017

AimTo provide a quantitative assessment of cataract theatre lists focusing on productivity and staffing levels/tasks using time and motion studies.MethodsNational Health Service (NHS) cataract theatre lists were prospectively observed in five different institutions (four NHS hospitals and one private hospital). Individual tasks and their timings of every member of staff were recorded. Multiple linear regression analyses were performed to investigate possible associations between individual timings and tasks.Results140 operations were studied over 18 theatre sessions. The median number of scheduled cataract operations was 7 (range: 5–14). The average duration of an operation was 10.3 min±(SD 4.11 min). The average time to complete one case including patient turnaround was 19.97 min (SD 8.77 min). The proportion of the surgeons’ time occupied on total duties or operating ranged from 65.2% to 76.1% and from 42.4% to 56.7%, respectively. The correlations of the surgical time to patient time in theatre was R2=0.95. A multiple linear regression model found a significant association (F(3,111)=32.86, P<0.001) with R2=0.47 between the duration of one operation and the number of allied healthcare professionals (AHPs), the number of AHP key tasks and the time taken to perform these key tasks by the AHPs.ConclusionsSignificant variability in the number of cases performed and the efficiency of patient flow were found between different institutions. Time and motion studies identified requirements for high-volume models and factors relating to performance. Supporting the surgeon with sufficient AHPs and tasks performed by AHPs could improve surgical efficiency up to approximately double productivity over conventional theatre models.
Effect of a population-level performance dashboard intervention on maternal-newborn outcomes: an interrupted time series study
Authors: Weiss Deborah , Dunn Sandra I , Sprague Ann E , Fell Deshayne B , Grimshaw Jeremy M , Darling Elizabeth , Graham Ian D , Harrold JoAnn , Smith Graeme N , Peterson Wendy E , Reszel Jessica , Lanes Andrea , Walker Mark C , Taljaard Monica 
Published: November 2017

ObjectivesTo assess the effect of the Maternal Newborn Dashboard on six key clinical performance indicators in the province of Ontario, Canada.DesignInterrupted time series using population-based data from the provincial birth registry covering a 3-year period before implementation of the Dashboard and 2.5 years after implementation (November 2009 through March 2015).SettingAll hospitals in the province of Ontario providing maternal-newborn care (n=94).InterventionA hospital-based online audit and feedback programme.Main outcome measuresRates of the six performance indicators included in the Dashboard.Results2.5 years after implementation, the audit and feedback programme was associated with statistically significant absolute decreases in the rates of episiotomy (decrease of 1.5 per 100 women, 95% CI 0.64 to 2.39), induction for postdates in women who were less than 41 weeks at delivery (decrease of 11.7 per 100 women, 95% CI 7.4 to 16.0), repeat caesarean delivery in low-risk women performed before 39 weeks (decrease of 10.4 per 100 women, 95% CI 9.3 to 11.5) and an absolute increase in the rate of appropriately timed group B streptococcus screening (increase of 2.8 per 100, 95% CI 2.2 to 3.5). The audit and feedback programme did not significantly affect the rates of unsatisfactory newborn screening blood samples or formula supplementation at discharge. No statistically significant effects were observed for the two internal control outcomes or the four external control indicators—in fact, two external control indicators (episiotomy and postdates induction) worsened relative to before implementation.ConclusionAn electronic audit and feedback programme implemented in maternal-newborn hospitals was associated with clinically relevant practice improvements at the provincial level in the majority of targeted indicators.
Social media and the intrauterine device: a YouTube content analysis
Authors: Nguyen Brian T , Allen Allison J 
Published: November 2017

BackgroundYouTube’s online archive of video testimonials related to health information are more commonly viewed than those developed by clinicians and professional groups, suggesting the importance of the patient experience to viewers. We specifically sought to examine the accuracy of information on, and projected acceptability of, the intrauterine device (IUD) from these YouTube testimonials.MethodsWe searched YouTube for videos about individual uploaders’ IUD experiences, using the search terms ‘intrauterine device’, ‘IUD’, ‘Mirena’ and ‘Paragard’. Given interest in user testimonials, we excluded professional and instructional videos belonging to commercial or non-profit entities. Two reviewers independently analysed the videos using a structured guide, with attention to inaccurate information.ResultsOf 86 identified videos, four videos featured clinicians and were excluded; 62 met inclusion criteria. Interrater agreement on IUD portrayal was good (K=0.73). Young (mean age 25, range 19–38, years), white (75%), nulliparous (61%) women primarily uploaded content. Most described placement of the LNG-IUS (65%), were posted within 1 month of insertion (45%), and mentioned side effects (66%) – bleeding, pain, and partner sensation of the strings. About one-third of videos contained inaccurate information (34%) and were thought to project an overall negative experience (30%). Videos portraying IUDs negatively were associated with inaccurate information and/or mention of side effects.ConclusionWhile one-third of IUD user testimonials on YouTube contained inaccurate information, the majority of IUD experiences were perceived by our study viewers to be positive.
The feasibility of an interactive voice response system (IVRS) for monitoring patient safety after discharge from the ED
Authors: Calder Lisa A , Cwinn A Adam , Gatien Mathieu , Gee Andrew , Larocque Natasha , Calder-Sprackman Samantha , De Gorter Ria , Zlepnig Jennifer , Stiell Ian G , Forster Alan J 
Published: November 2017

BackgroundReturn ED visits are frequent and may be due to adverse events: adverse outcomes related to healthcare received. An interactive voice response system (IVRS) is a technology that translates human telephone input into digital data. Use of IVRS has been explored in many healthcare settings but to a limited extent in the ED. We determined the feasibility of using an IVRS to assess for adverse events after ED discharge.MethodsThis before and after study assessed detection of adverse events among consecutive high-acuity patients discharged from a tertiary care ED pre-IVRS and post-IVRS over two 2-week periods. The IVRS asked if the patient was having a health problem and if they wanted to speak to a nurse. Patients responding yes received a telephone interview. We searched health records for deaths, admissions to hospital and return ED visits. Three trained emergency physicians independently determined adverse event occurrence. We analysed the data using descriptive statistics.ResultsOf 968 patients studied, patients’ age, sex, acuity and presenting complaint were comparable pre-IVRS and post-IVRS. Postimplementation, 393 (81.7%) of 481 patients had successful IVRS contact. Of these, 89 (22.6%) wanted to speak to a nurse. A total of 37 adverse events were detected over the two periods: 10 patients with 10 (6.5%) adverse events pre-IVRS and 16 patients with 27 (16.9%) adverse events post-IVRS. In the postimplementation period, the adverse events of seven patients were detected by the IVRS and five patients spontaneously requested assistance navigating post-ED care.ConclusionsThis was a successful proof-of-concept study for applying IVRS technology to assess patient safety issues for discharged high-acuity ED patients.