bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetes prevalence is associated with different community factors in the diabetes belt versus the rest of the United States
Authors: Myers Candice A. , Slack Tim , Broyles Stephanie T. , Heymsfield Steven B. , Church Timothy S. , Martin Corby K. 
Published: December 2016

ObjectiveTo investigate differences in community characteristics associated with diabetes prevalence between the Diabetes Belt and the rest of the contiguous United States (U.S.)MethodsCounty‐level adult diabetes prevalence estimates (i.e., percent of people [≥20 years] with diagnosed diabetes 2009) were used from the Centers for Disease Control and Prevention, in addition to data from the U.S. Census Bureau, U.S. Department of Agriculture, and U.S. Department of Health and Human Services, to carry out a spatial regime analysis to identify county‐level factors correlated with diabetes prevalence in the Diabetes Belt versus the remainder of the U.S.ResultsCounties outside of the Diabetes Belt demonstrated stronger positive associations between diabetes prevalence and persistent poverty and greater percentages of unemployed labor forces. For counties in the Diabetes Belt, diabetes prevalence showed a stronger positive association with natural amenities (e.g., temperate climate and topographic features) and a stronger negative association with fitness/recreation facility density.ConclusionsCommunity‐level correlates of diabetes prevalence differed between the Diabetes Belt and elsewhere in the U.S. Economic hardship was shown to be more relevant outside the Diabetes Belt, while recreational context effects were more pronounced among counties within the region. Prevention and treatment targets are geographically unique, and public health efforts should acknowledge these differences in crafting policy.
Angiomatoid fibrous histiocytoma: A case of local recurrence and metastases to loco‐regional lymph nodes that responded to chemotherapy
Authors: Ogden Sally , Harave Srikrishna , McPartland Jo , Brennan Bernadette , Jeys Lee , Losty Paul , Pizer Barry 
Published: December 2016

AbstractAngiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumour with intermediate malignant potential. We report the case of a patient with local recurrence of AFH in two locations and lymph node metastases 18 months after primary surgical excision. The patient was treated with six cycles of ifosfamide and doxorubicin chemotherapy and a further three courses of ifosfamide monotherapy. Reassessment imaging showed a good response to chemotherapy with reduction in size of the two tumours of local recurrence and the lymph node metastases. This case demonstrates that AFH can respond to chemotherapy, even though it is rarely used.
Incorporation of high‐dose 131I‐metaiodobenzylguanidine treatment into killer immunoglobulin‐like receptor/HLA‐ligand mismatched haploidentical stem cell transplantation for children with neuroblastoma who failed tandem autologous stem cell transplantation
Authors: Lee Ji Won , Kang Eun‐Suk , Sung Ki Woong , Yi Eunsang , Lee Soo Hyun , Yoo Keon Hee , Koo Hong Hoe 
Published: December 2016

AbstractBackgroundWe performed a pilot study (NCT 00793351) to evaluate the effectiveness and feasibility of a strategy incorporating high‐dose 131I‐metaiodobenzylguanidine (HD‐MIBG) treatment into killer immunoglobulin‐like receptor (KIR)/HLA‐ligand mismatched haploidentical stem cell transplantation (haplo‐SCT) in improving the survival of children with neuroblastoma who failed previous tandem autologous SCT.ProcedureIf the patient remained progression free with salvage treatment, HD‐MIBG treatment (18 mCi/kg) was given prior to reduced‐intensity conditioning (cyclophosphamide + fludarabine + antithymocyte globulin). Grafts from KIR/HLA‐ligand mismatched, preferably BX haplotype, haploidentical donors were transplanted to enhance the graft‐versus‐tumor (GVT) effect.ResultsA total of seven patients were enrolled and three donors had a BX haplotype. Toxicities during HD‐MIBG treatment and reduced‐intensity conditioning were mild. Neutrophil recovery and complete or near complete donor chimerism were rapidly achieved. Six patients experienced acute graft‐versus‐host disease (GVHD; grade I in five and grade III in one), and four of six evaluable patients experienced chronic GVHD (two mild and two severe). Four patients died from tumor progression, one died from sepsis without progression, and the other two remained alive in complete response during 34 and 48 months posttransplant. All three patients remained progression free after BX haplotype SCT, whereas the other four experienced progression after AA haplotype SCT.ConclusionsOur results suggest that the incorporation of HD‐MIBG treatment in haplo‐SCT and the use of BX haplotype donors might improve outcome, but this approach is currently limited by unacceptable GVHD. Further work focused on enhancement of GVT effects in relapsed neuroblastoma should be coupled with efforts to reduce GVHD.
Sporadic melanotic schwannoma with overlapping features of melanocytoma bearing a GNA11 mutation in an adolescent girl
Authors: Tatsi Christina , Bacopoulou Flora , Lyssikatos Charalampos , Belyavskaya Elena , Faucz Fabio R. , Stratakis Constantine A. 
Published: December 2016

AbstractMelanotic schwannoma (MS) is a soft tissue neoplasm that shares histologic features with melanocytic tumors and schwannomas. A type of MS, called psammomatous MS (PMS), is associated with Carney complex (CNC), which is caused by PRKAR1A mutations. Other pigmented neoplasms, such as uveal melanomas and melanocytomas (MCs), are associated with genetic defects in other genes including GNA11. We report an adolescent female with a large sporadic mesenteric MS with complex histologic findings reminiscent of both PMS and MC. The lesion carried a mutation of the GNA11 gene. We conclude that sporadic MSs may occur rarely in adolescents without CNC; MSs may also be associated with somatic GNA11 mutations.
Acute lymphoblastic leukemia in patients with Down syndrome with a previous history of acute myeloid leukemia
Authors: Tomizawa Daisuke , Endo Akifumi , Kajiwara Michiko , Sakaguchi Hirotoshi , Matsumoto Kimikazu , Kaneda Makoto , Taga Takashi 
Published: December 2016

AbstractPatients with Down syndrome (DS) are predisposed to acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) in early and later childhood, respectively, but rarely experience both. We herein discuss four patients with DS with ALL and a history of AML who were treated with various chemotherapies, one of whom later received a bone marrow transplantation. Three patients survived and remain in remission. One patient died of fulminant hepatitis during therapy. No common cytogenetic abnormalities in AML and ALL besides constitutional +21 were identified, indicating that the two leukemia types were independent events. However, the underlying pathomechanism of these conditions awaits clarification.
The added value of detailed early anomaly scan in fetuses with increased nuchal translucency
Authors: Zalel Yaron , Zemet Roni , Kivilevitch Zvi 
Published: December 2016

AbstractObjectiveThis study aims to assess the utility of a detailed early fetal anatomy scan prior to karyotyping in the management of pregnancies with an increased nuchal translucency (NT).MethodsThe study included fetuses with NT above the 99th centile. These women were offered the option of an early detailed fetal anatomy scan prior to genetic evaluation. The presence or absence of major sonographic findings was analyzed for its predictive value for fetal aneuploidy.ResultsAn increased NT >99th centile was detected in 43 fetuses (1.8%). Mean NT was 4.5 mm (range 3.4–9.0), and gestational age at the early fetal anatomy survey was 12.4 weeks (12–13.6). Major sonographic findings were present in 30 fetuses (69.8%); 24 of them underwent karyotyping, and it was abnormal in 14. Among the 13 fetuses without major sonographic findings, 12 had normal karyotype results, and 1 had aneuploidy, yielding a positive predictive value of 58.3% of early fetal anatomy scan for abnormal karyotype results. Multivariate logistic regression analysis showed that the presence of major sonographic findings was as an independent predictor of fetal aneuploidy (adjusted odds ratio 8.15).ConclusionA detailed early anatomy scan upon detection of increased NT has an important value in the prediction of fetal aneuploidy. © 2016 John Wiley & Sons, Ltd.
Association of serum PAPP‐A levels in first trimester with small for gestational age and adverse pregnancy outcomes: systematic review and meta‐analysis
Authors: Morris R. Katie , Bilagi Ashwini , Devani Pooja , Kilby Mark D. 
Published: December 2016

AbstractObjectivesTo determine association, and predictive ability, of first trimester maternal serum pregnancy associated plasma protein A (PAPP‐A) with adverse pregnancy outcomes.MethodSearches of Medline, Embase and CINAHL (inception September 2015) for studies including pregnant women with first trimester PAPP‐A and assessment of pregnancy outcomes. Study characteristics, quality and results extracted. Meta‐analysis of odds ratios (ORs), and likelihood ratios (LRs) and 95% confidence intervals (CI).ResultsThirty‐two studies including 175 240 pregnancies. PAPP‐A <5th centile had a moderate association with: birth weight <10th centile OR 2.08 (95% CI 1.89–2.29), <5th centile OR 2.83 (95% CI 2.52–3.18); pre‐eclampsia OR 1.94 (95% CI 1.63–2.30), preterm birth <37 weeks OR 2.09 (95% CI 1.87–2.33), and composite adverse outcome OR 3.31 (95% CI 1.80–5.11). The predictive ability was poor: Birth weight <10th centile LR + ve 1.96 (95% CI 1.58–2.43), LR‐ve 0.93 (95% CI 0.89–0.98); birth weight <5th centile LR + ve 2.65 (95% CI 2.35–2.99), LR‐ve 0.85 (95% CI 0.74–0.98); PTB <37 weeks LR + ve 1.84 (95% CI 1.41–2.39), LR‐ve 0.92 (95% CI 0.87–0.98).ConclusionsFirst trimester low maternal serum PAPP‐A is associated with adverse pregnancy outcome, but predictive values are poor. Further work should address PAPP‐A as a continuous variable in combination with other prognostic markers as a prediction model. © 2016 John Wiley & Sons, Ltd.
The emotion regulation questionnaire in women with cancer: A psychometric evaluation and an item response theory analysis
Authors: Brandão Tânia , Schulz Marc S. , Gross James J. , Matos Paula Mena 
Published: December 2016

AbstractObjectiveEmotion regulation is thought to play an important role in adaptation to cancer. However, the emotion regulation questionnaire (ERQ), a widely used instrument to assess emotion regulation, has not yet been validated in this context. This study addresses this gap by examining the psychometric properties of the ERQ in a sample of Portuguese women with cancer.MethodsThe ERQ was administered to 204 women with cancer (mean age = 48.89 years, SD = 7.55). Confirmatory factor analysis and item response theory analysis were used to examine psychometric properties of the ERQ.ResultsConfirmatory factor analysis confirmed the 2‐factor solution proposed by the original authors (expressive suppression and cognitive reappraisal). This solution was invariant across age and type of cancer. Item response theory analyses showed that all items were moderately to highly discriminant and that items are better suited for identifying moderate levels of expressive suppression and cognitive reappraisal. Support was found for the internal consistency and test‐retest reliability of the ERQ. The pattern of relationships with emotional control, alexithymia, emotional self‐efficacy, attachment, and quality of life provided evidence of the convergent and concurrent validity for both dimensions of the ERQ.ConclusionOverall, the ERQ is a psychometrically sound approach for assessing emotion regulation strategies in the oncological context. Clinical implications are discussed.
Hole‐extraction layer dependence of defect formation and operation of planar CH3NH3PbI3 perovskite solar cells
Authors: Nguyen Duc Cuong , Joe Sung‐yoon , Ha Na Young , Park Hui Joon , Park Ji‐Yong , Ahn Y. H. , Lee Soonil 
Published: December 2016

Three planar CH3NH3PbI3 (MAPbI3) solar cells having the same structure except a hole‐extraction layer (HEL) showed distinctive difference in operation characteristics. Analysis of frequency‐dependent capacitance and dielectric‐loss spectra of the three MAPbI3 devices showed two types of recombination‐loss channels with different time constants that we attributed respectively to interface and bulk defects. Discrepancy in defect formation among the three devices with a HEL of PEDOT:PSS, NiOx, or Cu‐doped NiOx was not surprising because grain‐size distribution and crystalline quality of MAPbI3 can be affected by surface energy and morphology of underlying HELs. We were able to quantify interface and bulk defects in these MAPbI3solar cells based on systematic and simultaneous simulations of capacitance and dielectric‐loss spectra, and current–voltage characteristics by using the device simulator SCAPS.
magnified imageDefect density reduction is essential for efficient planar solar cells. Defect density in MAPbI3 layers, with respect to which an open‐cell voltage and a fill factor vary, can be investigated by using capacitance–frequency spectra.
True nature of active layers in organic solar cells fabricated by sequential casting of donor and acceptor layers
Authors: Yim Jong Hyuk , Joe Sung‐yoon , Nguyen Duc Cuong , Ryu Shin Young , Ha Na Young , Ahn Y. H. , Park Ji‐yong , Lee Soonil 
Published: December 2016

The operation characteristics of nominal bilayer (BL) organic solar cells (OSCs), the active layers (ALs) of which consisted of sequentially casted bottom P3HT donor and top ICBA acceptor layers, resembled those of OSCs with bulk heterojunction (BHJ) ALs. Optical analysis and device simulations showed that such resemblance can be attributed to a similarity in the micromorphology of ALs; as‐deposited BL‐type ALs transformed spontaneously into BHJ‐type ALs. The inclusion of P3HT nanowires (NWs) in the donor layers resulted in different AL micromorphology and consequently a larger power conversion efficiency. Separate assessment of the exciton generation and charge–carrier transport and/or extraction showed that the contribution of P3HT NWs was more prominent in optical effects.
magnified imageTransformation of sequentially casted P3HT and ICBA layers into a bulk heterojunction layer accounts for good agreement between measured and simulated J–V curves.
Improving ensemble covariances in hybrid variational data assimilation without increasing ensemble size
Authors: Lorenc Andrew C. 
Published: December 2016

Increasing the size of the ensemble used in hybrid‐variational assimilation methods has been shown to be beneficial, but is computationally expensive. This work sets out to see whether similar improvements can be obtained from a smaller ensemble by better estimation of ensemble covariances. Methods for improving these are described and illustrated using a toy model. The optimal settings depend on the ensemble size, the criterion used to measure error and the errors in ensemble generation. A hybrid covariance, filtered by spectral localization using wavebands and scale‐dependent spatial localization, is shown to perform well and robustly.In the cycled ensemble data‐assimilation scheme used for numerical weather prediction (NWP), another method of increasing the effective ensemble size in covariance estimates is the use of time‐lagged and time‐shifted perturbations. This is demonstrated to be effective in the Met Office's hybrid‐4DEnVar system, both on its own and with waveband and scale‐dependent localization. The best such combination performs nearly as well as an increase in ensemble size from 44 to 200.
An efficient data‐filtering strategy for easy metabolite detection from the direct analysis of a biological fluid using Fourier transform mass spectrometry
Authors: Rathahao‐Paris Estelle , Alves Sandra , Debrauwer Laurent , Cravedi Jean‐Pierre , Paris Alain 
Published: December 2016

RationaleHigh‐throughput analyses require an overall analytical workflow including not only a robust and high‐speed technical platform, but also dedicated data‐processing tools able to extract the relevant information. This work aimed at evaluating post‐acquisition data‐mining tools for selective extraction of metabolite species from direct introduction high‐resolution mass spectrometry data.MethodsInvestigations were performed on spectral data in which seven metabolites of vinclozolin, a dicarboximide fungicide containing two chloride atoms, were previously manually identified. The spectral data obtained from direct introduction (DI) and high‐resolution mass spectrometry (HRMS) detection were post‐processed by plotting the mass defect profiles and applying various data‐filtering methods based on accurate mass values.ResultsExploration of mass defect profiles highlighted, in a specific plotting region, the presence of compounds containing common chemical elements and pairs of conjugated and non‐conjugated metabolites resulting from classical metabolic pathways. Additionally, the judicious application of mass defect and/or isotope pattern filters removed many interfering ions from DI‐HRMS data, greatly facilitating the detection of vinclozolin metabolites. Compared with previous results obtained by manual data treatment, three additional metabolites of vinclozolin were detected and putatively annotated.ConclusionsTracking simultaneously several specific species could be efficiently performed using data‐mining tools based on accurate mass values. The selectivity of the data extraction was improved when the isotope filter was used for halogenated compounds, facilitating metabolite ion detection even for low‐abundance species. Copyright © 2016 John Wiley & Sons, Ltd.
Performance of induction module cavity ring‐down spectroscopy (IM‐CRDS) for measuring δ18O and δ2H values of soil, stem, and leaf waters
Authors: Johnson J. E. , Hamann L. , Dettman D. L. , Kim‐Hak D. , Leavitt S. W. , Monson R. K. , Papuga S. A. 
Published: December 2016

RationaleInduction module cavity ring‐down spectroscopy (IM‐CRDS) has been proposed as a rapid and cost‐effective alternative to cryogenic vacuum distillation (CVD) and isotope ratio mass spectrometry (IRMS) for the measurement of δ18O and δ2H values in matrix‐bound waters. In the current study, we characterized the performance of IM‐CRDS relative to CVD and IRMS and investigated the mechanisms responsible for differences between the methods.MethodsWe collected a set of 75 soil, stem, and leaf water samples, and measured the δ18O and δ2H values of each sample with four techniques: CVD and IRMS, CVD and CRDS, CVD and IM‐CRDS, and IM‐CRDS alone. We then calculated the isotopic errors for each of the three CRDS methods relative to CVD and IRMS, and analyzed the relationships among these errors and suites of diagnostic spectral parameters that are indicative of organic contamination.ResultsThe IM‐CRDS technique accurately assessed the δ18O and δ2H values of pure waters, but exhibited progressively increasing errors for soil waters, stem waters, and leaf waters. For soils, the errors were attributable to subsampling of isotopically heterogeneous source material, whereas for stems and leaves, they were attributable to spectral interference. Unexpectedly, the magnitude of spectral interference was higher for the solid samples analyzed directly via IM‐CRDS than for those originally extracted via CVD and then analyzed by IM‐CRDS.ConclusionsThere are many types of matrix‐bound water samples for which IM‐CRDS measurements include significant errors from spectral interference. As a result, spectral analysis and validation should be incorporated into IM‐CRDS post‐processing procedures. In the future, IM‐CRDS performance could be improved through: (i) identification of the compounds that cause spectral interference, and either (ii) modification of the combustion step to completely oxidize these compounds to CO2, and/or (iii) incorporation of corrections for these compounds into the spectral fitting models used by the CRDS analyzers. Copyright © 2016 John Wiley & Sons, Ltd.
Characterization of crude oil asphaltenes by coupling size‐exclusion chromatography directly to an ultrahigh‐resolution mass spectrometer
Authors: Ghislain Thierry , Molnárné Guricza Lilla , Schrader Wolfgang 
Published: December 2016

RationaleFossil fuels are one of the most important energy resources until new sustainable materials become available. To optimize the upgrading processes of these materials characterization of the remaining heavy materials is of great importance.MethodsAsphaltenes are the most difficult fraction of crude oil to process due to the limited number of solvents in which they can be dissolved. Chromatographic separation methods need to consider the difficulties associated with these limitations. Size‐exclusion chromatography (SEC) in combination with Fourier transform Orbitrap mass spectrometry (MS) combines the capabilities of ultrahigh resolution and very high mass accuracy with a separation method that allows using solvents as mobile phase for asphaltene separation.ResultsA chromatographic method was developed that shows the separation of asphaltenes according to their molecular mass. A simplification of the samples was achieved by reducing the number of compounds present in a single spectrum compared to infusion data. Direct detection by mass spectrometry additionally allows a distinction of different isomers present in the complex samples.ConclusionsDirect coupling of SEC with ultrahigh‐resolution mass spectrometry allows the study of the most difficult to analyze fraction of crude oil, the asphaltene fraction. Separation reduces the complexity of individual spectra and, therefore, also reduces suppression and discrimination effects. The separation of structural isomers which cannot be characterized by MS alone gives an added dimension to the analysis of asphaltenes. Copyright © 2016 John Wiley & Sons, Ltd.
Flood Analysis Supported by Low‐cost Geometric Modelling
Authors: Zazo S. , Rodríguez‐Gonzálvez P. , Molina J.‐L. , Hernández‐López D. , González‐Aguilera D. 
Published: December 2016

AbstractToday, it is increasingly clear that non‐stationarity hydrological and hydraulic variables and processes are occurring largely because of global warming. Accordingly, extreme hydrological events are becoming more common over time, and their effects are creating greater negative impacts on the environment (fluvial geomorphology and floodplains) and society (flood damage). Given this situation, the implementation of adaptation‐mitigation measures is vital, as well as an increased knowledge of the interaction between water and physical environments. In the binominal water‐terrain, having a reliable digital elevation model (DEM) is essential because of its important influence on fluvial modelling. However, this is frequently a technical‐economic problem. The aim of this paper is first to evaluate the compatibility between hydraulics and geometrics for fluvial applications and second to determine the quality of a novel DEM by robust estimators. This was obtained through the photogrammetric processing of digital aerial images acquired from a low‐cost camera mounted on an alternative aerial platform. Flood modelling and hydraulic parameters were obtained with the assistance of photogrammetric DEM (mesh size: 0.15 m, vertical accuracy: 0.102 ± 0.081 m, point density: ≈40 point/m2). Finally, our other goal is to develop a comparative analysis between light detection and ranging and digital photogrammetry on‐demand. This comparison revealed that flood modelling by photogrammetric DEM was considerably more detailed than that by light detection and ranging‐DEM, mainly because of higher point density and vertical accuracy. Consequently, flood analysis assisted by this novel geometric modelling approach qualifies as a reliable and competitive approach. Copyright © 2016 John Wiley & Sons, Ltd.