bluuebunny/crossref_metadata_2025_split huggingface dataset:
Darkening on lead‐based pigments: Microbiological contribution
Authors: Rosado Tânia , Gil Milene , Mirão José , Candeias António , Caldeira Ana Teresa 
Published: December 2015

AbstractThe biodeterioration/biodegradation process is an important issue for the conservation of cultural heritage that needs urgent answers to their rehabilitation. In this way, the role of microorganisms in surfaces alteration was exploited. This work revealed a strong relationship between the microbiological proliferation and the damaged areas, evidencing the important role of the microorganisms in mural paintings alteration process. The oxidation of lead‐based pigments noticeably contributes to the pigments alteration, and seems to be correlated with the presence of biodeteriorative microorganisms. The study of the mechanisms underlying the microbiological attack of mural paintings has been explored to understand as much as possible the proliferative ability and biodeteriorative capacity of the microorganisms, related to darkening on lead‐based pigments. © 2015 Wiley Periodicals, Inc. Col Res Appl, 41, 294–298, 2016
Role of perioperative antibiotic treatment in parotid gland surgery
Authors: Shkedy Yotam , Alkan Uri , Roman Benjamin R. , Hilly Ohad , Feinmesser Raphael , Bachar Gideon , Mizrachi Aviram 
Published: December 2015

AbstractBackgroundThe value of routine prophylactic antibiotic treatment in parotid gland surgery remains undetermined.MethodsA retrospective analysis was conducted of all patients who underwent parotidectomy at a university‐affiliated tertiary care center between 1992 and 2009. Patients with insufficient data, specifically regarding postoperative complications and antibiotic administration were excluded from the study cohort.ResultsA total of 593 patients underwent parotidectomy during the study period. After exclusion, 464 patients were eligible for the study. Perioperative antibiotic treatment was given to 206 patients (45%). There was no difference in wound infection rates between patients who received perioperative antibiotic therapy and those who did not (p = .168). Multivariate analysis showed that female sex, neck dissection, and drain output >50 cc/24 hours were predictive of postoperative wound infection.ConclusionRoutine prophylactic antibiotic treatment has no role in parotid gland surgery. Perioperative antibiotic treatment is recommended for patients undergoing extensive parotid gland surgery with neck dissection. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1876–E1880, 2016
Recruitment of mesenchymal stem cells and macrophages by dual release of stromal cell‐derived factor‐1 and a macrophage recruitment agent enhances wound closure
Authors: Kim Yang‐Hee , Tabata Yasuhiko 
Published: December 2015

AbstractIn this study, the wound closure of mouse skin defects was examined in terms of recruitment of mesenchymal stem cells (MSC) and macrophages. For the cells recruitment, stromal derived factor‐1 (SDF‐1) of a MSC recruitment agent and sphingosine‐1 phosphate agonist (SEW2871) of a macrophages recruitment agent were incorporated into gelatin hydrogels, and then released in a controlled fashion. When applied to a skin wound defect of mice, gelatin hydrogels incorporating mixed 500 ng SDF‐1 and 0.4, 0.8, or 1.6 mg SEW2871‐micelles recruited a higher number of both MSC and macrophages than those incorporating SDF‐1 or phosphate buffered saline. However, the number of M1 phenotype macrophages for the hydrogel incorporating mixed SDF‐1 and SEW2871‐micelles recruited was remarkably low to a significant extent compared with that for those hydrogel incorporating 0.4, 0.8, or 1.6 mg SEW2871‐micelles. On the other hand, the number of M2 macrophages 3 days after the implantation of the hydrogels incorporating SDF‐1 and 0.4 mg SEW2871‐micelles significantly increased compared with that for other hydrogels. In vivo experiments revealed the hydrogels incorporating SDF‐1 and 0.4 mg SEW2871‐micelles promoted the wound closure of skin defect to a significant stronger extent than those incorporating SEW2871‐micelles, SDF‐1, and a mixture of SDF‐1 and higher doses of SEW2871‐micelles. It is concluded that the in vivo recruitment of MSC and macrophages to the defects may contribute to the tissue regeneration of skin wound. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 942–956, 2016.
Validation of eGFP fluorescence intensity for testing in vitro cytotoxicity according to ISO 10993‐5
Authors: Miller Felicitas , Hinze Ulf , Chichkov Boris , Leibold Wolfgang , Lenarz Thomas , Paasche Gerrit 
Published: December 2015

AbstractISO 10993‐5 provides one of the accepted standards for testing the biotoxicity of new materials. All of the recommended test procedures rely upon the uptake or metabolism of dye by living cells. Results of direct contact tests can be potentially compromised by interaction or adsorption of the dye or its metabolic products. Therefore, the aim of the current study was to validate the use of the eGFP signal of transfected NIH‐3T3 fibroblasts with the results of the MTT test in order to provide a test procedure that is very close to the ISO 10993‐5 but has the advantage of not relying on the addition of dye. Our tests show that the MTT assay detects cytotoxicity in the eGFP NIH‐3T3 cells at least as well as in the L929 cells. To facilitate the validation, we chose to integrate the fluorescence measurements into the MTT test procedure. To that end, an additional washing step was introduced. Additionally, medium without phenol red was used, resulting in a very high correlation of both measurements. Without these modifications, the fluorescence test was comparable to the MTT test in its ability to detect the cytotoxic potential of substances; however, it did result in slightly elevated IC50 concentrations. As the results of both tests correlated highly, measurement of the eGFP signal appears to present a reliable tool for detecting cytotoxicity of materials in line with the ISO 10993‐5 norm with the advantage of avoiding the addition of dyes and the subsequent potential interaction with test materials. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 715–722, 2017.
Fabrication of chitosan/gallic acid 3D microporous scaffold for tissue engineering applications
Authors: Thangavel Ponrasu , Ramachandran Balaji , Muthuvijayan Vignesh 
Published: December 2015

AbstractThis study explores the potential of gallic acid incorporated chitosan (CS/GA) 3D scaffolds for tissue engineering applications. Scaffolds were prepared by freezing and lyophilization technique and characterized. FTIR spectra confirmed the presence of GA in chitosan (CS) gel. DSC and TGA analysis revealed that the structure of chitosan was not altered due to the incorporation of GA, but thermal stability was significantly increased compared to the CS scaffold. SEM micrographs showed smooth, homogeneous, and microporous architecture of the scaffolds with good interconnectivity. CS/GA scaffolds exhibited approximately 90% porosity on average, increased swelling (600–900%) and controlled biodegradation (15‐40%) in PBS (pH 7.4 at 37°C) with 1 mg/mL of lysozyme. CS/GA scaffolds showed 2‐4 fold decrease in CFUs (p < 0.05) for both gram positive and gram negative bacteria compared to the CS scaffold. Cytotoxicity of these scaffolds was evaluated using NIH 3T3 L1 fibroblast cells. CS/GA 0.25% scaffold showed similar viability with CS scaffold at 24 and 48 h. CS/GA scaffolds (0.5–1.0%) showed 60–75% viability at 24 h and 90% at 48 h. SEM images showed that an increased cell attachment was observed for CS/GA scaffolds compared to CS scaffolds. These findings authenticate that CS/GA scaffolds were cytocompatible and would be useful for tissue engineering applications. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 750–760, 2016.
Synoptic‐climatological evaluation of the classifications of atmospheric circulation patterns over Europe
Authors: Huth Radan , Beck Christoph , Kučerová Monika 
Published: December 2015

ABSTRACTThis study evaluates the classifications of atmospheric circulation patterns collected in the COST733 database (COST733cat) in terms of their ability to stratify daily surface temperature and precipitation in 12 domains covering the whole of Europe. The classifications differ in the classification methods used, in the number of types, the variable(s) classified, the number of days in a sequence that are classified and in whether the classification is based on year‐round or seasonal data. Several classification methods that perform fairly well are identified; they include a simple k‐means clustering, a k‐means clustering preceded by hierarchical cluster analysis, Litynski's method, and a classification based on circulation prototypes. On the other hand, there are a couple of classification methods that do not provide a good stratification of temperature and precipitation: orthogonally and obliquely rotated principal component analysis in a T‐mode, Lund's correlation method, Kirchhofer's sums‐of‐squares method, and Erpicum's method. Some methods tend to perform better on large domains, while others tend to perform better on smaller domains; however, the sensitivity of most classification methods to the domain size appears to be small. Several methods exhibit a geographical dependence of their performance, e.g. the method based on circulation prototypes tends to perform better in the northern domains, while Jenkinson–Collison and Erpicum's methods perform better in the southern domains. Classifications of 4‐day sequences are usually better in stratifying surface temperature than ordinary instantaneous classifications; the opposite is true for precipitation. Adding a mid‐tropospheric variable (500 hPa heights or 1000/500 hPa thickness) to sea level pressure as a classified variable improves the skill of classifications in stratifying temperature.
Prediction of survival and tumor recurrence in patients undergoing surgery for pancreatic neuroendocrine neoplasms
Authors: Kaltenborn Alexander , Matzke Svenja , Kleine Moritz , Krech Till , Ramackers Wolf , Vondran Florian W. R. , Klempnauer Jürgen , Bektas Hüseyin , Schrem Harald 
Published: December 2015

BackgroundThis study strives to define prognostic models for outcome after surgery for malignant pancreatic neuroendocrine tumors.MethodsForty‐one patients were included. Prognostic models for mortality and disease recurrence were developed with multivariate binary logistic regression.ResultsThe proposed prognostic model for tumor recurrence risk after surgery in percentage (AUROC = 0.774, 95%CI = 0.611–0.937) is: Risk in % = Exp(Y)/(1 + Exp(Y)), with Y = −4.360 + (0.015 × tumor diameter in cm) + (0.010 × preoperative platelet count in thousand/μl) + (1.077 × distant metastases, if yes = 1; if no = 0) + (−0.026 × Ki‐67‐positive cells in %) + (−1.086 × upper abdominal pain, if yes = 1; if no = 0). The proposed prognostic model for observed 3‐year survival probability after surgery in % (AUROC = 0.932, 95%CI = 0.857–0.999) is: Survival probability in % = Exp(Y)/(1 + Exp(Y)), with Y = −12.492 + (0.054 × preoperative platelet count in thousand/μl) + (0.112 × minimal distance of the resection margin from the tumor in mm) + (−1.574 × number of positive lymph nodes) + (2.292 × histological tumor infiltration, if yes = 1; if no = 0)ConclusionsThe platelet count was identified as a relevant risk factor. Proposed prognostic models with good model‐fit display properties that indicate potential clinical usefulness. J. Surg. Oncol. 2016;113:194–202. © 2015 Wiley Periodicals, Inc.
Quantification of structurally related aliphatic amino alcohols in l‐valinol by hydrophilic interaction liquid chromatography separation combined with postcolumn derivatization and fluorescence detection
Authors: Douša Michal , Stach Jan , Gibala Petr , Lemr Karel 
Published: December 2015

The amino alcohols in l‐valinol were effectively separated and quantified using hydrophilic interaction chromatography with fluorescence detection. The influence of the mobile phase (salt type, buffer concentration, and pH) on retention was studied. A column TSKgel amide and mobile phase consisting of 10 mM acetate buffer pH 4.0 and acetonitrile (20:80, v/v) provided well‐separated symmetric peaks of analytes. Fluorescence detection was performed using postcolumn derivatization with o‐phtaldialdehyde/2‐mercaptoethanol at an excitation and emission wavelength of 345 and 450 nm, respectively. Simple sample pretreatment and very high sensitivity represent the main advantages of the developed method. After validation, the method was successfully applied to the analysis of commercial samples of l‐valinol.
Nocturia in Patients With Parkinson's Disease
Authors: Smith Matthew , Seth Jai , Batla Amit , Hofereiter Johann , Bhatia Kailash P. , Panicker Jalesh N. 
Published: December 2015

AbstractBackgroundWaking up from sleep more than once to pass urine, known as nocturia, is an important nonmotor symptom in Parkinson's disease (PD). Very little is known about the cause for nocturia. The aim of this work was to evaluate lower urinary tract (LUT) symptoms in patients withPDreporting nocturia using standardized validated questionnaires and bladder diaries and to assess the impact of nocturia on quality of life and sleep.MethodsTwenty‐three consecutive patients withPD(17 males, 6 females; mean age: 68.5 years; range, 50–85) referred to a specialist uro‐neurology clinic reporting nocturia according to the International Continence Society definition were included. Patients measured their daily fluid intake, urinary output per void, and recorded these with the timing of voids on a 3‐day bladder diary. Standardized questionnaires were used to assessLUTsymptoms (Urinary Symptom Profile, International Prostate Symptom Score, and Qualiveen Short Form) and sleep quality (Parkinson's Disease Sleep Scale).ResultsMean duration ofPDwas 10.1 years, and mean severity on H & Y scale was 3.0 (range, 1.0–5.0). Median duration ofLUTsymptoms was 6.0 years. Mean night‐time urinary frequency was 3.5 (range, 1.0–7.3), and mean nocturnal maximum voided volume was 242 mL. Mean Nocturnal Polyuria Index (NPi) was 0.4 (range, 0.13–0.75), and 13 patients (56.5%) had nocturnal polyuria (NPi > 0.33). Patients with nocturnal polyuria reported more‐severeLUTsymptoms that impacted quality of life and sleep.ConclusionsIn this preliminary study, nocturnal polyuria seems to be common in patients withPDreporting nocturia and appears to affect quality of life and sleep, though this was not statistically significant. The bladder diary is an essential tool in the assessment of nocturia in patients withPD.
3–10 GHz, 6.54‐mW CMOS ultrawideband low‐noise amplifier using a hybrid structure
Authors: Sun Mingyuan Y. , Lim Wei Meng , Shi Zhengyu Y. , Yu Qi , Liu Yang 
Published: December 2015

ABSTRACTA low‐noise amplifier (LNA) for 3–10 GHz ultrawideband applications is realized in 65‐nm CMOS technology. A self‐biased resistive feedback structure with inductive peaking topology is used to achieve wideband matching as well as flat gain, and the current reuse technique is used to reduce power consumption. Furthermore, a series source negative feedback resistor is introduced to achieve a significant input matching improvement for the purpose of saving chip area. The LNA exhibits 13.2‐dB power gain, 4.38‐dB minimum noise figure, and 6.54‐mW power consumption under a 1.2‐V supply voltage. Moreover, only two inductors are used in the circuit, occupying a silicon area of 0.072 mm2. It is able to achieve functionality with a small silicon area and a low‐power consumption among recently published CMOS‐based wideband LNAs. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:293–295, 2016
Design of hexa‐channel triplexer with modified manifold‐coupled structure
Authors: Xu Jin 
Published: December 2015

ABSTRACTIn this article, a novel hexa‐channel triplexer with modified manifold‐coupled structure is presented. Three asymmetrical coupling shorted stub loaded stepped‐impedance resonator dual‐band bandpass filter is used to replace the single‐band channel filters in the conventional manifold‐coupled triplexer. The proposed modified manifold‐coupled structure is constructed by two different three‐element lowpass Π‐networks for achieving the required phase shift and filtering performance. Good agreements can be observed between the simulated and measured results. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:279–283, 2016
Fiber ring resonator using a cavity ring‐down interrogation technique for curvature sensing
Authors: Magalhães R. , Silva S. O. , Frazão O. 
Published: December 2015

ABSTRACTIn this work, it is demonstrated a fiber ring resonator connected to an interrogation system usually implemented on a cavity ring‐down technique. A long‐period grating (LPG) was inserted in the resonant cavity, being operated as a curvature sensor. The experimental results demonstrate that using this setup, different sensitivities can be achieved in terms of analyzing decay time over the radius of the curvature and over curvature. The LPG sensor presented higher sensitivity with larger radius of curvature, namely 6.91 μs/m. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:267–270, 2016
A compact UWB bandpass filter based on CRLH via‐less CPW‐fed
Authors: ••• Nilotpal , Upadhyay Dileep Kumar 
Published: December 2015

ABSTRACTA novel compact coplanar waveguide (CPW)‐fed ultrawideband (UWB) bandpass filter is proposed in this article. The composite right‐/left‐handed transmission line structure is designed on a single layer via‐less CPW‐fed, which reduces the fabrication complexity and makes the structure more feasible. The filter exhibits stopband rejection level greater than 10 dB while maintaining insertion loss less than 0.3 dB throughout the passband range. The filter has a compact size of 18.4 mm × 4.5 mm. The performance of the proposed UWB bandpass filter is compared with the previously reported UWB bandpass filters. All the performance parameters of the filter are evaluated by full‐wave electromagnetic simulator IE3D, based on the method of moments and all the results are verified by measurement. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:276–279, 2016
Channel‐spacing tunable multiwavelength thulium‐doped fiber laser based on four‐wave mixing effect in a high nonlinear fiber
Authors: Wei Yizhen , Yang Xiong , Mao Barerem‐Melgueba , Lu Yang , Zhou Xuefang , Bi Meihua , Yang Guowei 
Published: December 2015

ABSTRACTWe propose a channel‐spacing tunable multiwavelength thulium‐doped fiber laser in the 2‐μm waveband. Stable multiwavelength operation at room temperature is achieved using four‐wave mixing effect in a high nonlinear fiber. The wavelength spacing and number of channels of the multiwavelength fiber laser are adjustable by controlling the effective length of polarization‐maintaining fiber in the intracavity Lyot–Sagnac filter. Four channels with 3.0‐nm spacing, eight channels with 1.5‐nm spacing, and 11 channels with 1.0‐nm spacing are experimentally demonstrated. Characteristics of output stability and extinction ratio are also evaluated. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:337–340, 2016
Circularly polarized antenna using a double layered via‐less high impedance surface
Authors: Gupta Gaurangi , Harish Ayyangar R. 
Published: December 2015

ABSTRACTLow profile (0.019λ) linearly and circularly polarized antennas are constructed by placing a printed bow tie dipole above a double layered via‐less high impedance surface (HIS). Asymmetry in the HIS and the orientation of the dipole are adjusted to achieve either circular polarization or linear polarization with low cross‐polarization level. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:340–343, 2016
A compact planar wide‐band balun with high isolation based on coupled‐line and composite right–left‐handed transmission line
Authors: Wu Yongle , Zhuang Zheng , Jiao Lingxiao , Liu Yuanan 
Published: December 2015

ABSTRACTA novel compact single‐layer wide‐band planar balun with high isolation is proposed. It is composed of a broadband coupled‐line power divider and an improved phase shifter using coupled‐line (CL) and composite right/left‐handed transmission line (CRLH TL). The CRLH structure is used to realize the advanced phase response while the coupled‐line power divider can be utilized to provide the performance of wide‐band matching and isolation. For demonstration, a novel planar microstrip balun operating at ∼2.75 GHz is designed and implemented. The proposed balun has many advantages including compact single‐layer structure, excellent return loss, high isolation, and perfect phase response. Finally, good agreements between the simulated and measured results verify this design. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:372–376, 2016
Novel axe‐shaped circular microstrip quad band antenna
Authors: Nafiza N. , Sreeja B. S. , Devi R. Chithra , Radha S. 
Published: December 2015

ABSTRACTNovel axe‐shaped circular microstrip quad band cost effective antenna with simple structure is developed. This design consists of circular patch with elliptical and circular slots loading provide an axe shape patch along with stubs offer quad bands. The proposed antenna provides resonance at the frequencies of 2.8, 4, 5.4, and 6.2 GHz which covers the applications of WLAN/WI‐FI and WIMAX. The measured results of reflection coefficient and VSWR are presented. The proposed design provides minimum rejection ratio of 23 dB and maximum rejection ratio of 15 dB. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:400–402, 2016
V‐band 18.3 dB/1.6 dBm three‐stage amplifier with inductive self‐biasing in 130‐nm CMOS
Authors: Zhang Mingming , Wu Hsien‐Shun , Tzuang Ching‐Kuang C. 
Published: December 2015

ABSTRACTThe common source amplifier design with the inductive self‐biasing is presented. The proposed design can establish the biasing and the impedance matching with two transmission line elements. Both theoretical and experimental verifications confirm that the three‐stage prototype achieves a gain per stage of 6.1 dB, and the output P1dB of 1.6 dBm with 29 mW power consumption at 53 GHz based on the standard CMOS 130 nm 1P8M technology. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:409–413, 2016
Optical communication system for high‐capacity LAN
Authors: Perrone P. , Betti S. , Rutigliano G.G. 
Published: December 2015

ABSTRACTIn this article, it is proposed a model for multilevel polarization modulation tailored to Local Area Networks (LAN's), which exploits optical fiber intrinsic properties to obtain, with the same bandwidth, a higher single‐channel throughput with a reduced receiver complexity. This is achieved through a “fluid” constellation of confined bands. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:389–393, 2016