bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avaliação da Sustentabilidade na Região Metropolitana do Vale do Paraíba e Litoral Norte – RMVPLN
Authors: Carniello Monica Franchi , Dos Santos Moacir José , Calderaro da Silva Nelson Marcos 
Published: October 2024

A Região Metropolitana do Vale do Paraíba (RMVPLN), formada por 39 municípios, foi criada em 2012. A pesquisa tem como objetivo avaliar a sustentabilidade da RMVPLN, por meio da aplicação da ferramenta Barômetro da Sustentabilidade (BS) em duas fases distintas, antes e depois da criação da região metropolitana por lei. Quanto ao método, a pesquisa caracteriza-se como documental, com modelagem descritiva e uma abordagem quantitativa nas análises. Foi possível demonstrar que os municípios da RMVPLN são heterogêneos quanto às suas características e, como região, não atendem plenamente aos requisitos de formação das regiões metropolitanas. Quanto à sustentabilidade da região, embora tenha avançado um pouco, ainda se encontra na escala de quase insustentabilidade. Conclui-se que, na primeira década de metropolização, não houve avanços significativos no consolidado dos índices do bem-estar do ecossistema e no bem-estar humano na perspectiva regional. Quando analisados individualmente, os municípios apresentam resultados distintos quanto à sustentabilidade.
O Rural nos instrumentos de planejamento territorial: o caso dos municípios do COREDE Norte do RS
Authors: Oliveira Daniela , Alexandre Bariviera Cassio 
Published: October 2024

Mesmo sendo maioria no território brasileiro, as regiões rurais e os municípios de pequeno porte populacional são frequentemente desassistidos pelo poder público no que se refere ao planejamento territorial, ficando à mercê de instrumentos básicos e generalistas, normalmente direcionados as áreas urbanas, ou elaborados para grandes centros urbanos. Dadas as mudanças ocorridas na trajetória do planejamento territorial no Brasil, principalmente no que se refere ao período pós Constituição Federal de 1988, e ao Estatuto da Cidade, este trabalho se propõe a investigar se e como o rural tem sido tratado pelos instrumentos de planejamento territorial dos 32 municípios do Corede Norte-RS. Para isso realizou-se uma pesquisa documental nos instrumentos de planejamento e leis orgânicas dos municípios em análise (obtidos em sítios digitais das prefeituras municipais e em repositórios de legislações disponíveis na internet). Os documentos foram catalogados e posteriormente analisados, a fim de identificar elementos relacionados com as questões e hipóteses previamente estabelecidas. Observou-se a predominância de instrumentos básicos da política urbana em praticamente todos os municípios analisados, os quais, além de perpetuarem noções exclusivamente urbanas para o planejamento, e exclusivamente agrícolas para o espaço rural, relegam o espaço rural a outras normativas federais, por vezes, orientadas por instituições diversas (Incra, Conama, Código Tributário, etc.) e que não chegam na escala local do planejamento. Nos casos onde o rural foi incluído pelos instrumentos de planejamento dos municípios, estes seguem atrelando-o a ótica de oposição à cidade e atribuindo-lhe apenas uma destinação agro-silvo-pastoril.
A rare case of early-onset neonatal sepsis caused by Proteus mirabilis in the first infant of tetrachorionic triamniotic triplets
Authors: Karpova A. L. , Mostovoi A. V. , Avdei O. V. , Dudkina E. A. , Zagdai S. P. , Anikeeva L. A. , Khoteeva A. P. , Orlova O. E. , Karpov N. Yu. 
Published: October 2024

Early-onset neonatal sepsis (EОNS) is one of the most severe diseases of the neonatal period and is often coupled to extremely unfavorable outcomes. In many ways, the severity of the condition and the results of newborn nursing depend on the etiology of the bacterial process. The major EОNS pathogens are traditionally considered to be Streptococcus group B and E. coli, much less common are other Gram-negative bacteria including casuistic cases caused by caused by Proteus mirabilis (P. mirabilis). The article provides a review on the P. mirabilis role in developing neonatal sepsis with pathogen-specific disease course and outcomes. In addition, we describe a clinical case of P. mirabilis-caused EОNS not only primarily characterized by the rarity of its causative agent, but also that it proceeded with a more favorable brain damage in contrast to similar cases described worldwide and because the neonatal EОNS developed in one of triplets, with two other babies being asymptomatic despite that P. mirabilis was also detected.
The Effects of Health Insurance on Demand for Healthcare Services in Tanzania
Authors: N.E. Kubetta , P.S. Omary , V.J. Mugula, 
Published: October 2024

ABSTRACT: Consistent healthcare financing systems within a particular nation or community have been regarded as vital for making universal healthcare access. This study intended to examine the influence of health insurance on the demand for healthcare services and the influence of socio-economic, demographic and hospital-related factors on demand for health care services in Tanzania context. The study employed secondary data, which were analysed by descriptive statistics and the results were presented in tables and percentages. Econometric analysis was also done using binary probit regression model to determine the factors influencing demand for health care services in Tanzania. The instrumental variable was applied to address the problem of endogeneity of health insurance. The regression results revealed that gender, education level, household size, income, treatment cost, perceived health quality and health insurance type were significant and positively linked with demand for health care services. However, marital status was also significant but negatively associated with the demand for healthcare services. The study concluded that, despite of the efforts made by the government and other stakeholders on emphasis over having health insurance, the enrolment to health insurance schemes is still low although it has been noted to significantly influence the demand for health care services. Lastly, the paper recommends that the government and other stakeholders are required to formulate or strengthen the formulated policy in practice, purposively to improve access, affordability and the quality of health care services. Governmental and non-governmental organizations (NGO`s) and other stakeholders should put more effective strategies to improve coverage but also reduce the financial burden caused by illness. Also, the government needs to subsidize the healthcare sector, especially to the poor and provide subsidies to private healthcare facilities, improvement of insurance type, specifically, the NHIF which needs to increase coverage. Furthermore, health care managers should educate other people and make a clear observation on factors that make individuals demand for health care because they have a great role in the health care sector as well as strategies to improve household`s income to meet the health needs in Tanzania.
Dzieje wilanowskiej nieruchomości ziemskiej
Authors: Kłusek Mirosław 
Published: October 2024

Wilanów najczęściej kojarzy się nam tylko z Janem III Sobieskim oraz Muzeum Pałacu Króla Jana III w Wilanowie. Zdecydowanie mniej wiemy na temat kwestii gospodarczo-ekonomicznych i związków funkcjonalno-gospodarczych wilanowskiej nieruchomości ziemskiej. Celem niniejszej publikacji jest wypełnienie tej luki. Opracowanie powstało na podstawie wieloletnich badań nad aspektami gospodarczej działalności wilanowskiej nieruchomości ziemskiej oraz licznych monografii i artykułów już opublikowanych przez autora.
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Książka adresowana jest do badaczy zajmujących się problematyką nieruchomości, rzeczoznawców majątkowych, adwokatów, radców prawnych, pracowników administracji samorządowej. Może również stanowić cenne źródło wiedzy dla przedstawicieli nauki, m.in. ekonomistów, historyków gospodarczych oraz studentów wydziałów prawa i administracji, a także studentów studiów ekonomicznych.
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Risk factors of pyometra in cat at several clinics in Kediri, East Java, Indonesia
Authors: Rosyta Pegy , Rimayanti Rimayanti  , Budi Utomo  , Jola Rahmahani  , Yulianna Puspitasari  , Wiwik Misaco Yuniarti  
Published: October 2024

Pyometra is a reproductive disease that most often affects cats which is caused by bacterial infection of the uterus. This study aims to determine the risk factors that could influence the occurrence of pyometra in cats. The study was conducted at the Four Leg Pet Care, Asa Animal Clinic, and K-5 Animal Care in Kediri regency in December 2021 to February 2022. This retrospective cohort study took secondary data for the period 2020 to 2021 as research material and found 35 cats diagnosed with pyometra. The odds ratio was calculated to analyze the associations to some factors including age, body weight, use of hormonal contraception, frequency of administration of hormonal contraception, hormonal contraceptive drugs used, dose of hormonal contraception given. Analysis of the relationship between risk factors for pyometra showed that the factors age, use of hormonal contraception, and frequency of giving hormonal contraceptives each have p values ​​of 2.17, 2.13, and 2.13, respectively. It could be concluded that age, use of hormonal contraception, and frequency of administration of hormonal contraception influenced or had an association with the risk of pyometra in cats.
Compatibility between Pseudomonas fluorescens and Trichoderma harzianum in disease control of Fusarium tomato wilt under greenhouse condition
Authors: Jediaa I . A. , Ali A . A. , Abbas B. A. , Musa Sh . A. , Hassan H.R. , Muhamed L. J. 
Published: October 2024

اجريت هذه الدراسة لتقويم كفاءة ست عزلات من البكتريا Pseudomonas fluorescens وفطر Trichoderma harzianum والتوافق بينهما في مكافحـة مرض الذبول الفيوزارمي على الطماطه المتسبب عن الفطر Fusarium oxysporum f.sp.lycopersici تحت ظروف البيت الزجاجي . اظهرت النتائج تفوقا عاليا لعزلة البكتريا (B3) وفطر الترايكوديرما (T1) في خفض نسبة الاصابة للبادرات بعد 14 يـومـا اذ بلغت 13,3% و21% على التوالي مقارنة بالشاهد (40%) كما ادت الى خفض شدة الاصابــة اذ بلغت 28% و30% وعلى التوالي مقارنة بالشاهد (90%) بعد 35 يوما ، واعطت هاتان العزلتان قدره استيطانية عالية على الجذور بعد 21 يوما سواء أكانت بمفردها او فـــي معاملة التوافق . كما اظهرت الدراسة تفوق معاملة التوافق بين العزلتين (B3 ، (T1 فـي خفض نسبة الاصابة للبادرات بعد 14 يوما اذ بلغت 10,3% مقارنة بالشاهــد (36,3%) وكـذلك في شدة الاصابة 16% مقارنة بالشاهد 88% بعد 35 يوما من الزراعـــة . كما اظهرت تفــوقا معنويا في زيادة بعض معايير النمو الخضري.
Effect of Hardening to drought tolerance on the moisture contents of sunflower plant. II moisture percentage in leaves and heads
Authors: AL-Jobori Kamil. M. 
Published: October 2024

يهدف العمل الى دراسة التغيرات الحاصلة في المحتوى الرطوبي لأوراق وأقراص نباتات زهرة الشمس خلال مراحل نموها تحت ظروف التطويع لتحمل الجفاف . نفذت تجارب حقلية خلال ربيعي 2000 و2001 . أستعمل تصميم ألألواح ألمنشقة-ألمنشقة بثلاث مكررات.شملت ألالواح ألرئيسية على معاملات ألري الى 100% (ألري ألكامل) و75 و50%من ألماء ألجاهز في ألتربة،وأحتل ألصنفان يوروفلور وفلامي ألالواح ألثانوية. أشتملت ألدراسة على أربع معاملات نقع للبذور:ألمقارنة(من دون نقع)وألنقع في ألماء وألنقع في محلول ألكلتار(250 جزء من ألمليون) وألنقع في محلول ألبكس (500 جزء من ألمليون) ألتي أحتلت ألالواح تحت ألثانوية.تنقع ألبذورلمدة24 ساعة ثم تجفف هوائيا لغاية وصولها ألى أوزانها ألاصلية قبل ألنقع.حسبت كميات ألمياه لكل رية لتعويض ألاستنزاف ألرطوبي خلال موسم ألنمو بأستعمال مقياس ألرطوبة ألنيتروني. أجريت جميع ألعمليات ألزراعية حسب ألتوصيات.
أوضحت ألنتائج بأن معاملات الري لم تؤثر في النسبة المئوية للرطوبة في ألأوراق ، في حين أدى الري ألاعتيادي وألشد 600 كيلوباسكال الى زيادة النسبة المئوية للرطوبة في ألأقراص بنسبة 1.69 و2.44 % عن الشد 800 كيلوباسكال بعد 58 يوما من ألزراعة في ألموسم2001. تفوقت معاملتي الري الاعتيادي والشد 800 كيلوباسكال بنسبة 3.66 و 1.52% على معاملة الشد 600 بعد 72 يوما من الزراعة في متوسط ألموسمين .تفوق ألصنف يوروفلور على الصنف فلامي في نسبة الرطوبة في أوراق نباتاته بعد86 يوما من ألزراعة بنسبة 5.34 في ألموسم 2001 و 2.76%في متوسط ألموسمين.كما تفوق في نسبة الرطوبة في أقراص نباتاته بنسبة 2.79% في الموسم 2001. ساهمت عمليات نقع ألبذور قبل الزراعة في الماء ومحاليل الكلتار والبكس في زيادة نسبة الرطوبة في ألأوراق بنسبة 3.73 و2.65 و 4.13% عن بعد 58 بوما من الزراعة في متوسط الموسمين ، ونسبة الرطوبة في ألأقراص بنسبة 4.05 و 5.12 و 5.44% بعد 58 يوما من الزراعة في الموسم 2000 وبنسبة 2.80 و3.09 و2.86% في الموسم 2001 قياسا بمعاملة من دون نقع. يستنتج من هذه ألدراسة أهمية نقع ألبذور قبل ألزراعة في ألماء أومحاليل منظمات ألنمو لتحسين العلاقات المائية لأوراق وأقراص النباتات وزيادة نسبة التزهير وعقد البذور وامتلاءها عند تعرضها للجفاف.
The Effect of some inducer agents in increase the production of Enterocin U36 produced by Enterococcus faecalis U36 that isolated from Urinary Tract Infection
Authors: Kandela Nuha J. , Aziz Ghazi M. , Khanika Hausain 
Published: October 2024

الانتروسين U36 ( (ENT U36, هو بكتريوسين منتج من بكترياfaecalis U36 Enterococcus المعزولة محليا من عينات ادرار اخذت من مرضى يعانون من التهابات السبيل البولي ، ذي فعالية مثبطة لعدد من الانواع البكتيرية القريبة الصلة التي تعود للبكتريا المنتجة لحامض اللاكتيك Lactic acid bacteria والتي شملت E. faecalis S10. و Lactococcus lactis و L. fermentum، بالاضافة الى فعاليته التثبيطية ضد بعض الممرضات البكتيرية والتي تضمنت الانواع الاتية Listeria mono cytogenesو Staphylococcus auraus وStreptococcus spp. و Escherchia coli والعصيات المكونة للسبورات s Bacillus subtili.
حددت الظروف المثلى لانتاج الانتروسين من العزلة المحلية EFU36 باستخدام المزارع المغمورة اذ اظهرت النتائج ان وسط الانتاجية الامثل للانتروسين اشتمل على مصادر كاربونية ومصادر نايتروجينية وبعض الاملاح ولقح الوسط بحجم نهائي 2% من لقاح بعدد خلايا حية 1X910 خلية / مليلتر و رقم هيدروجيني امثل 6 عند درجة حرارة مثلى (35 – 37) ْم بسرعة 120 دورة / دقيقة اذ بلغت الفعالية النوعية 310 x 91 وحدة/ مليغرام بروتين. ودرس تاثير عدد من المحفزات للانتاجية مثل Chloramphenicol و B12 Vitamin وFolic Acid و Mitomycin-C في الوسط الامثل للانتاجية للعزلة المنتخبة وقد لوحظ ان استخدام 1.5% من المايتومايسين –C قد اعطى اعلى فعالية نوعية عندما بلغت X 103 310 وحدة / مليغرام بروتين عند اضافته بعد 3 ساعات من المدة المثلى للانتاج.
The effect of NPK fertilizer on some physiological characters of Petroselinum hortense
Authors: Al-Kaisi, W.A. , Al-Hallaq A.M. , Hassan R. A. 
Published: October 2024

أجريت تجربة لدراسة تأثير سماد NPK بالتركيزين 0.25 ,0.50 غم/ كغم تربة في بعض الصفات الفسيولوجية لنبات المعدنوس Petroselinum hortense .
أظهرت النتائج بأن التسميد بالتركيزين أعلاه أدى إلى زيادة الوزن الجاف للنبات ومعدل النمو المطلق ومعدل النمو النسبي للنبات , كذلك النسبة المئوية لعناصر النتروجين والفسفور والبوتاسيوم في النبات فقد كانت الفروق في صفات النبات قيد الدراسة مختلفة معنوياً بالتركيز الأول مقارنة بالثاني .
S-Generalized supplemented modules
Authors: Al-Bahrany B. H. , Al-Rikabiy A. J. 
Published: October 2024

أكسيو قدم المفهوم الأتي، يقال للمقاس M بأنه مكمل معمم إذا كان لكل مقاس جزئي N من M، يوجد مقاس جزئي K من M بحيث أن K +N=M وNK  Rad(K).نها حمادة والهاشمي قدما المفهوم الأتي، يقال للخاصية S المعرفة على المقاسات بأنها خاصية شبه جذرية أذا تحقق الأتي:1. ليكن N→ M :f تشاكلاً شاملاً. أذا كانت M مقاساً يملك الخاصية S فأن N مقاساً يملك الخاصية S.2. كل مقاس M يحوي على المقاس الجزئي S(M).هذه الملاحظات قادتنا إلى اقتراح تعريف المقاسات المكملة المعممة من النمط S. لتكن S خاصية شبه جذرية، يقال للمقاس M المعرف على الحلقة R بأنه مقاس مكمل معمم من النمط S. إذا كان لكل مقاس جزئي N من M، يوجد مقاس جزئي K من M بحيث أن M=N+K وN∩ K  S(K).الغرض الرئيسي من هذا البحث هو تطوير خواص المقاسات المكملة المعممة من النمط S. لقد أعطينا مجموعة من القضايا الجديدة وأوضحنا المفاهيم بأمثلة.
Preparedness for injuries sustained while hiking 14,000ft peaks in Colorado
Authors: Twardowski Nicole , Cooper Spencer , Zapata Isain , Ross David 
Published: October 2024

Abstract

Background: Every year hikers and climbers sustain injuries on Colorado’s highest peaks, with fatalities occasionally occurring. The purpose of this study was to investigate injury types and supplied carried by people hiking 14,000 feet (4,267.2 meters) peaks in Colorado. As the popularity of the sport increases, research exploring hiker experience, and injuries becomes imperative so that participants are better informed.
Methods: An exploratory descriptive survey study using an online survey of a hiking group of 330 participants was conducted. These participants reported on injuries, supplies and practices of those attempting these hikes.
Results: A total of 70% of respondents reported having sustained injuries while attempting a 14,000 feet peak hike, however these injuries were rarely serious. A large proportion of participants report being prepared for managing injuries by carrying medical supplies such as pain relievers (78.2%), adhesive bandages (77.9%), and bandages (66.7%). The major issue in their attempts was reported to be running out of water (39.4%), and getting lost (21.2%). Only a third of the participants had taken outdoor wilderness survival classes.
Conclusion: Most frequent injuries sustained by participants tend to be minor and are more likely to occur or being witnessed as the activity is performed more frequently. This research serves as a reference of common injuries as well the types of first aid items that hikers commonly utilize and the associations between injuries and how hikers prepare for a 14,000 feet peak.
Constructing a Potential HLA Haplo-homozygous Induced Pluripotent Stem Cell Haplobank Using Data from an Umbilical Cord Blood Bank
Authors: He Ji , He Yanmin , Zhan Qigang , Wu Zhipan , Sheng Qi , Zhang Wei , Zhu Faming 
Published: October 2024

Abstract

Background: iPSCs (induced pluripotent stem cells) can differentiate into any type of cell and have potential uses in regenerative medicine for the treatment of many diseases. However, reducing immune rejection is a key problem in the application of iPSCs that can be solved by the development of haplobanks containing specially selected iPSC lines. Methods: To study the feasibility of constructing an HLA (human leukocyte antigen)-matched induced pluripotent stem cell haplobank in China, 5421 umbilical cord blood samples were randomly collected from the Umbilical Cord Blood Bank of Zhejiang Province. The HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci were genotyped using next-generation sequencing. Using HLA genotype data at the high-resolution level, the number of HLA homozygous donors needed to cover a certain percentage of the Chinese population and the feasibility of constructing a high-matching iPSC haplobank were estimated.
Results: Thirteen HLA-A, -B, and -DRB1 and 11 HLA-A, -B, -C, -DRB1, and -DQB1 haplotype homozygotes were observed among the stored umbilical CB units which were as HLA zero-mismatched iPSC donors cumulatively matched 37.01% and 32.99% of 5421 potential patients respectively. The analysis showed that 100 distinct HLA-A, -B, and -DRB1 and HLA-A, -B, -C, -DRB1, and -DQB1 homozygous haplotypes would cover 72.74% and 67.87% of Chinese populations, respectively, and 600 HLA-A, -B, -C, -DRB1, and -DQB1 homozygous haplotypes would cover more than 90% of Chinese populations. PCA(principal component analysis)of published HLA data from different populations revealed that the frequency of these haplotypes in Asian populations is different from those in European populations.
Conclusion: The results suggested that at least some HLA-homozygous iPSC lines developed from Chinese individuals will not only be useful for covering the Chinese population but will also cover other Asian populations. A high-matching iPSC haplobank generated from umbilical CB units may be an economical and effective option in an allogeneic model of iPSC therapy.
Inhibition of circular RNA 006029 alleviates pancreatic β-cell injury through the AKT/mTOR signaling pathway
Authors: Huang Kunlin , Feng Jiaxing , Zheng Ying , Wang Zhen , Zhou Zhiguang 
Published: October 2024

Abstract

Type 1 diabetes mellitus (T1DM) is characterized by the damage of pancreatic β-cells induced by autoimmune responses. Circular RNAs (circRNAs) serve important regulatory functions in the pathogenesis of T1DM, but the underlying mechanisms require more substantiation. This study focused on a novel circRNA circ006029 to investigate its regulations on β-cell damage. The potential involvement of circ006029 in β-cell proliferation, apoptosis, autophagy, and inflammatory responses was investigated via experiments such as CCK-8, qRT-PCR, and immunoblot. The utilization of a cytokine mixture, and specific molecular blockers Rapamycin and Capivasertib were applied to investigate the pathway by which circ006029 regulates in β-cell damage. Transcriptome sequencing and bioinformatics analysis were conducted to explore differentially expressed mRNAs related to circ006029 regulation. The expression of circ006029 was observed to increase in damaged MIN6 cells. The inhibition of circ006029 serves a protective role in MIN6 β-cells by promoting β-cell proliferation and attenuating apoptosis. circ006029-knockdown could augment β-cell autophagy and attenuate apoptosis through the AKT/mTOR signaling pathway. Moreover, circ006029 might be involved in the inflammatory response of MIN6 cells. These findings suggest that circ006029 may serve a detrimental role in β-cell damage, which provides new ideas for exploring the mechanism of β-cell damage in early insulitis in T1DM.
Detection of Aβ40 in Cerebrospinal Fluid and Plasma of Alzheimer’s Disease patients Using Photoelectrochemical Biosensors
Authors: Li Liting , Wei Na , Guo Yiwei , Zhu Xingyu , Wang Lin , Zhu Yanzhao , Fang Ke , Ma Shenhui , Zhang Yingying , Zhang Yan , Zhou Xiaofei , Zhao Gang , Bu Yuyu , Zhou Linfu 
Published: October 2024

Abstract

Early diagnosis of Alzheimer's disease (AD) is crucial for disease treatment and improving patient prognosis. However, due to the low content, complex composition, and individual differences of target proteins in real clinical specimens of AD patients, ultra sensitive detection of early biomarkers for AD still faces challenges. This study presents the development of an ultrasensitive TiO₂/Au-C₃N₄ heterojunction photoelectrochemical biosensor, fabricated using electrophoretic deposition (EPD), for the quantitative detection of amyloid-beta 40 (Aβ40) protein in Alzheimer’s disease (AD) patients. the sensor exhibited excellent performance, featuring a linear detection range from 10− 15 to 10− 11 g/mL and a remarkably low detection limit(LOD) of 0.33 fg/mL.The validation in clinical settings demonstrated the successful detection of Aβ40 protein in real samples(including human cerebrospinal fluid (CSF), human plasma, and artificial saliva), which effectively distinguished between AD patients and non-AD controls. Additionally, the integration with the Single Molecule Array (SiMoA) method validated the sensor’s accuracy in identifying control groups. These results strongly suggest that semiconductor photoelectrochemical (PEC) biosensors possess significant potential as cost-effective, rapid, and highly sensitive tools for detecting ultra-trace substances in human body fluids, which offers promising opportunities for the early screening of high-risk populations for AD.