bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges in Diagnosing Medication Resins in Surgical Pathology Specimens: A Crystal-Clear Review Guide
Authors: Gonzalez Raul S. , Lagana Stephen M. , Szeto Oliver , Arnold Christina A. 
Published: February 2017

Context.—
Medication resins, including Kayexalate, sevelamer, and bile acid sequestrants, can be encountered in gastrointestinal tract specimens. Their classic histologic appearances have been well documented, but pathologist recognition of the resins is 75%, patient history is not always available, and atypical morphologic findings are sometimes present.

Objective.—
To offer a succinct overview of resins in the gastrointestinal tract, including typical and atypical appearances, in order to serve as a quick reference guide.

Data Sources.—
The study comprises published literature, survey data, and our personal experiences.

Conclusions.—
Classic morphology is the benchmark for identifying these resins, but color, location, and fish scale pattern can deviate from the norm, making proper identification a challenge. Patient history should be sought whenever possible, and ancillary staining is an option when necessary. Additionally, the presence of resins should prompt the pathologist to search for potentially related diagnoses (namely, causes of diarrhea in patients on bile acid sequestrants and diagnoses associated with renal failure in patients on Kayexalate or sevelamer).
Une extrême droite en émergence? Les pages Facebook pour la charte des valeurs québécoises
Authors: Nadeau Frédérick , Helly Denise 
Published: February 2017

À l’automne 2013, le Parti Québécois dépose un projet de « Charte des valeurs québécoises » (projet de loi n°60) qui veut laïciser l’État provincial, en interdisant notamment le port de signes religieux par les employés de l’État. S’ensuivent des débats âpres et parfois haineux autour du statut de la religion et de l’islam en particulier dans la société provinciale. Le présent texte propose une analyse thématique de dix pages Facebook en faveur du projet de loi. Il tente de déterminer la nature politique des arguments que ces pages développent, et pose la question de l’émergence d’une extrême droite au Québec en recourant aux concepts d’extrême droite et de droite radicale présentement débattus dans la littérature européenne. Il conclut que les arguments et les thèmes développés dans ces pages les rattachent à une mouvance de « droite radicale ».
Rapport au diplôme et sentiment de surqualification des diplômés universitaires québécois
Authors: Vultur Mircea 
Published: February 2017

Dans cet article, nous analysons les dimensions subjectives de la détention du diplôme ainsi que les phénomènes qui en découlent (la surqualification), en mettant l’accent non pas sur la valeur marchande des diplômes, mais sur leur valeur d’usage, c’est-à-dire considérée du point de vue de leur détenteur. Nous montrons que la valeur du diplôme ne dépend pas seulement des quantités relatives de diverses catégories de diplômés en concurrence pour l’emploi, mais également des qualités intrinsèques que le diplôme confère à ses détenteurs. Nos analyses sont fondées sur un matériau empirique formé de 30 entrevues avec des diplômés universitaires québécois, réalisées cinq ans après l’obtention de leur diplôme dans le cadre d’une étude rétrospective de leur cheminement scolaire et de leur trajectoire d’insertion professionnelle.
Juifs dans la Cité québécoise
:
Anctil, Pierre, À chacun ses Juifs. 60 éditoriaux pour comprendre la position du Devoir à l’égard des Juifs (1910-1947), Québec, Septentrion, 2014Anctil, Pierre et Simon Jacobs (dir.), Les Juifs de Québec. Quatre cents ans d’histoire, Québec, Presses de l’Université du Québec, 2015. (Coll. Patrimoine urbain)
Authors: Bérubé Harold 
Published: February 2017

La communauté juive est une composante importante de la société québécoise. Depuis les années 1980, et en grande partie grâce aux efforts de Pierre Anctil, elle est intégrée à son historiographie. Anctil poursuit cette entreprise dans deux ouvrages récents. Publiant et commentant les éditoriaux que Le Devoir a consacrés à la communauté juive, au Québec et ailleurs dans le monde, il enrichit et nuance un portrait qu’il avait déjà esquissé dans ses premiers travaux. Codirigeant un ouvrage consacré aux Juifs de la ville de Québec, il nous rappelle, avec ses collaborateurs, que cette communauté s’est aussi enracinée à l’extérieur de Montréal.
Desafios e possibilidades da implantação da metodologia sala de aula invertida: Estudo de caso em uma Instituição de Ensino Superior privada
Authors: Milhorato Paulo Rodrigues , Guimaraes Eloísa Helena Rodrigues 
Published: February 2017

Mudança é palavra que caracteriza a passagem da sociedade industrial para a sociedade do conhecimento. Neste sentido, faz-se necessário repensar os processos educacionais, vistos como alternativa para suprir a lacuna entre o ensino tradicional e as demandas da sociedade atual. Nesse cenário, surge como possibilidade o modelo proposto por Eric Mazur, nos anos 1990, denominado sala de aula invertida, que utiliza a tecnologia como apoio ao ensino. Assim, este artigo tem como objetivo descrever os impactos da metodologia sala de aula invertida em um Instituição de Ensino Superior (IES) Privada. A metodologia de pesquisa baseou-se em uma abordagem qualitativa e quantitativa e utilizou dados colhidos por meio de questionário disponibilizado na ferramenta google docs e/ou impressos, aplicado aos alunos de uma unidade da Faculdade Pitágoras, localizada na região metropolitana de Belo Horizonte, em entrevistas com professores envolvidos e observação participante. Os resultados revelam que o perfil do aluno é favorável à aplicação do modelo sala de aula invertida: são jovens e em constante contato com a tecnologia. Entretanto sua rotina diária, uma formação de base deficiente e a necessidade de trabalhar para custear uma IES privada tornam complexa a aplicação deste modelo.
Empirical model of long‐time variations of galactic cosmic ray particle fluxes
Authors: Kuznetsov N. V. , Popova H. , Panasyuk M. I. 
Published: February 2017

AbstractThe galactic cosmic ray (GCR) particle flux model has been developed by using the experimental data obtained during the solar cycles 21–24. The model calculates fluxes of GCR particles (with charge z from 1 to 28 and energy E from 80 up to 105 MeV/nucleon) in the interplanetary space (ecliptic plane) as a function of solar activity (sunspot number) and the heliocentric distance. GCR proton fluxes computed by the model for the case of a possible decrease in solar activity during solar cycles 25 and 26 are discussed.
Sensitivity of typhoon modeling to surface waves and rainfall
Authors: Zhao Biao , Qiao Fangli , Cavaleri Luigi , Wang Guansuo , Bertotti Luciana , Liu Li 
Published: February 2017

AbstractImproving intensity simulation and forecast of tropical cyclones has always been a challenge, although in recent years the track forecasts have been remarkably improved. In this study, we explore the sensitivity of typhoon simulation to three physical processes using a fully coupled atmosphere‐ocean‐wave model. Two storms, a strong and a weak one, have been chosen. The effects of wave breaking induced sea spray, ocean vertical mixing associated with nonbreaking surface waves, and sea surface cooling due to intense rainfall are assessed by means of a set of numerical experiments. The results show and confirm that sea spray leads to an increase of typhoon intensity by enhancing the air‐sea heat flux, while nonbreaking wave‐induced vertical mixing and rainfall lead to a decrease. Each process can be relevant, depending on wind and wave conditions. These can vary dramatically when typhoons interact with not sufficiently well‐defined coastal areas, typically an archipelago. Compared with the control runs, when all the three physical processes are considered, the (absolute) difference between the modeled sea level pressure and best track data is reduced from 26.05 to 0.70 hPa for typhoon Haiyan, and from −9.42 to −8.67 hPa for typhoon Jebi. We have found a steady overestimate of the dimensions of the typhoons. We have verified an extreme sensitivity to the initial conditions, especially when small differences in the typhoon track may imply different relevance of the physical processes, like the ones we have considered, governing the evolution of the storm.
Current‐induced dissipation in spectral wave models
Authors: Rapizo H. , Babanin A. V. , Provis D. , Rogers W. E. 
Published: February 2017

AbstractDespite many recent developments of the parameterization for wave dissipation in spectral models, it is evident that when waves propagate onto strong adverse currents the rate of energy dissipation is not properly estimated. The issue of current‐induced dissipation is studied through a comprehensive data set in the tidal inlet of Port Phillip Heads, Australia. The wave parameters analyzed are significantly modulated by the tidal currents. Wave height in conditions of opposing currents (ebb tide) can reach twice the offshore value, whereas during coflowing currents (flood), it can be reduced to half. The wind‐wave model SWAN is able to reproduce the tide‐induced modulation of waves and the results show that the variation of currents is the dominant factor in modifying the wave field. In stationary simulations, the model provides an accurate representation of wave height for slack and flood tides. During ebb tides, wave energy is highly overestimated over the opposing current jet. None of the four parameterizations for wave dissipation tested performs satisfactorily. A modification to enhance dissipation as a function of the local currents is proposed. It consists of the addition of a factor that represents current‐induced wave steepening and it is scaled by the ratio of spectral energy to the threshold breaking level. The new term asymptotes to the original form as the current in the wave direction tends to zero. The proposed modification considerably improves wave height and mean period in conditions of adverse currents, whereas the good model performance in coflowing currents is unaltered.
Suppression of a single pair of mushroom body output neurons in Drosophila triggers aversive associations
Authors: Ueoka Yutaro , Hiroi Makoto , Abe Takashi , Tabata Tetsuya 
Published: February 2017

Memory includes the processes of acquisition, consolidation and retrieval. In the study of aversive olfactory memory in Drosophila melanogaster, flies are first exposed to an odor (conditioned stimulus, CS+) that is associated with an electric shock (unconditioned stimulus, US), then to another odor (CS−) without the US, before allowing the flies to choose to avoid one of the two odors. The center for memory formation is the mushroom body which consists of Kenyon cells (KCs), dopaminergic neurons (DANs) and mushroom body output neurons (MBONs). However, the roles of individual neurons are not fully understood. We focused on the role of a single pair of GABAergic neurons (MBON‐γ1pedc) and found that it could inhibit the effects of DANs, resulting in the suppression of aversive memory acquisition during the CS− odor presentation, but not during the CS+ odor presentation. We propose that MBON‐γ1pedc suppresses the DAN‐dependent effect that can convey the aversive US during the CS− odor presentation, and thereby prevents an insignificant stimulus from becoming an aversive US.
Visible‐Light‐Mediated Oxygenation Reactions using Molecular Oxygen
Authors: Bian Changliang , Singh Atul K. , Niu Linbin , Yi Hong , Lei Aiwen 
Published: February 2017

AbstractAs a clean, inexpensive and widely available energy source, visible light has received increased attention and research interest from all around the world. In the field of synthetic organic chemistry, more and more groups are pursuing visible‐light‐mediated chemical transformations. Various types of reactions using visible light as an initiator have been described in the past several decades (mainly in the past ten years). It has become a powerful tool for constructing new chemical bonds and has shown wide application prospects in organic synthesis. In addition, there have been several reviews summarizing the progress of visible‐light‐mediated syntheses from different points of view. This review provides a summary on the development of visible‐light‐mediated oxygenation reactions using molecular oxygen, and can be used as a reference guide to direct the design of new reactions.
Reaction of Donor‐Acceptor Cyclobutanes with Indoles: A General Protocol for the Formal Total Synthesis of (±)‐Strychnine and the Total Synthesis of (±)‐Akuammicine
Authors: Feng Liang‐Wen , Ren Hai , Xiong Hu , Wang Pan , Wang Lijia , Tang Yong 
Published: February 2017

AbstractA ligand‐promoted catalytic [4+2] annulation reaction using indole derivatives and donor‐acceptor (D‐A) cyclobutanes is reported, thus providing an efficient and atom‐economical access to versatile cyclohexa‐fused indolines with excellent levels of diastereoselectivity and a broad substrate scope. In the presence of a chiral SaBOX ligand, excellent enantioselectivity was realized with up to 94 % ee. This novel synthetic method is applied as a general protocol for the total synthesis of (±)‐akuammicine and the formal total synthesis of (±)‐strychnine from the same common‐core scaffold.
Biodegradable nanofibrous scaffolds as smart delivery vehicles for amino acids
Authors: Maione Silvana , Pérez‐Madrigal Maria M. , del Valle Luis J. , Díaz Angélica , Franco Lourdes , Cativiela Carlos , Puiggalí Jordi , Alemán Carlos 
Published: February 2017

ABSTRACTThe encapsulation of amino acids (AAs) and their correct preservation before they are ingested are challenging tasks. Nonpolar (l‐alanine and l‐phenylalanine), polar (l‐cysteine hydrochloride and l‐asparagine), and charged (l‐lysine hydrochloride and l‐aspartic acid) AAs were loaded into biodegradable and nontoxic poly(tetramethylene succinate) (PE44) nanofibers (NFs) with electrospinning. The loading of AAs considerably affected the morphology, topography, thermal properties, and wettability of the PE44 NFs. Furthermore, although the AAs crystallized in a phase separated from the polymeric matrix, the distribution of such crystals changed into PE44 NFs and depended on their chemical nature. Release assays in enzyme‐free solutions provided evidence that very significant amounts of AAs were retained in the NFs after 7 days, whereas assays in the lipase‐containing solution (because lipase performs essential roles in the digestion) showed almost complete release after a few hours. Lipase preferentially attacked the PE44 regions responsible for the retention of AAs in the biphasic system and favored the almost immediate release of the biomolecules. The results displayed in this study, combined with the biocompatibility, biodegradability, and potential use of the PE44 NFs as edible nonnutritional elements, suggest that the loaded PE44–AA NFs could be used to supply essential and conditional AAs. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44883.
Improved mechanical and barrier properties of starch film with reduced graphene oxide modified by SDBS
Authors: Ge Xuesong , Li Hui , Wu Lin , Li Ping , Mu Xindong , Jiang Yijun 
Published: February 2017

ABSTRACTStarch is regarded as one of the most promising biopolymers to replace the fossil resources. However, due to the poor mechanical properties, high sensitivity to humidity, and low barrier property, the development of starch‐based materials has been limited. In this study, they improved the mechanical and barrier properties of starch film with reduced graphene oxide (RGO) modified by sodium dodecyl benzene sulfonate (SDBS). The hydrophilia of modified RGO (r‐RGO) was improved and result in a good dispersion in oxidized starch (OS) matrix. The tensile strength of the r‐RGO‐4/OS film increased to 58.5 MPa which was more than three times of the OS film (17.2 MPa). Besides, both the water vapor and oxygen barrier properties of r‐RGO/OS film were improved greatly compared with OS and GO/OS films. Moreover, the r‐RGO/OS film could protect against UV light effectively due to its lightproof performance. In conclusion, the r‐RGO/OS composite film has great potential applications in packaging industry. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44910.
Improved performance of solid polymer electrolytes for structural batteries utilizing plasticizing co‐solvents
Authors: Ihrner Niklas , Johansson Mats 
Published: February 2017

ABSTRACTThis study describes the formulation, curing, and characterization of solid polymer electrolytes (SPE) based on plasticized poly(ethylene glycol)‐methacrylate, intended for use in structural batteries that utilizes carbon fibers as electrodes. The effect of crosslink density, salt concentration, and amount of plasticizer has been investigated. Adding a plasticizing solvent increases the overall performance of the SPE. Increased ionic conductivity and mechanical performance can be attained compared to similar systems without plasticizer. At ambient temperature, ionic conductivity (σ) of 3.3 × 10−5 S cm−1, with a corresponding storage modulus (E′) of 20 MPa are reached. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44917.
Fermentative production of L‐pipecolic acid from glucose and alternative carbon sources
Authors: Pérez-García Fernando , Max Risse Joe , Friehs Karl , Wendisch Volker F. 
Published: February 2017

AbstractCorynebacterium glutamicum is used for the million‐ton scale production of amino acids and has recently been engineered for production of the cyclic non‐proteinogenic amino acid L‐pipecolic acid (L‐PA). In this synthetic pathway L‐lysine was converted to L‐PA by oxidative deamination, dehydration and reduction by L‐lysine 6‐dehydrogenase (deaminating) from Silicibacter pomeroyi and pyrroline 5‐carboxylate reductase from C. glutamicum. However, production of L‐PA occurred as by‐product of L‐lysine production only. Here, the author show that abolishing L‐lysine export by the respective gene deletion resulted in production of L‐PA as major product without concomitant lysine production while the specific growth rate was reduced due to accumulation of high intracellular lysine concentrations. Increasing expression of the genes encoding L‐lysine 6‐dehydrogenase and pyrroline 5‐carboxylate reductase in C. glutamicum strain PIPE4 increased the L‐PA titer to 3.9 g L−1, and allowed faster growth and, thus, a higher volumetric productivity of 0.08 ± 0.00 g L−1 h−1 respectively. Secondly, expression of heterologous genes for utilization of glycerol, xylose, glucosamine, and starch in strain PIPE4 enabled L‐PA production from these alternative carbon sources. Third, in a glucose/sucrose‐based fed‐batch fermentation with C. glutamicum PIPE4 L‐PA was produced to a titer of 14.4 g L−1 with a volumetric productivity of 0.21 g L−1 h−1 and an overall yield of 0.20 g g−1.
Learning and memory disabilities in IUGR babies: Functional and molecular analysis in a rat model
Authors: Camprubí Camprubí Marta , Balada Caballé Rafel , Ortega Cano Juan A. , Ortega de la Torre Maria de los Angeles , Duran Fernández‐Feijoo Cristina , Girabent‐Farrés Montserrat , Figueras‐Aloy Josep , Krauel Xavier , Alcántara Soledad 
Published: February 2017

AbstractIntroductionIntrauterine growth restriction (IUGR) is the failure of the fetus to achieve its inherent growth potential, and it has frequently been associated with neurodevelopmental problems in childhood. Neurological disorders are mostly associated with IUGR babies with an abnormally high cephalization index (CI) and a brain sparing effect. However, a similar correlation has never been demonstrated in an animal model. The aim of this study was to determine the correlations between CI, functional deficits in learning and memory and alterations in synaptic proteins in a rat model of IUGR.MethodsUtero‐placental insufficiency was induced by meso‐ovarian vessel cauterization (CMO) in pregnant rats at embryonic day 17 (E17). Learning performance in an aquatic learning test was evaluated 25 days after birth and during 10 days. Some synaptic proteins were analyzed (PSD95, Synaptophysin) by Western blot and immunohistochemistry.ResultsPlacental insufficiency in CMO pups was associated with spatial memory deficits, which are correlated with a CI above the normal range. CMO pups presented altered levels of synaptic proteins PSD95 and synaptophysin in the hippocampus.ConclusionsThe results of this study suggest that learning disabilities may be associated with altered development of excitatory neurotransmission and synaptic plasticity. Although interspecific differences in fetal response to placental insufficiency should be taken into account, the translation of these data to humans suggest that both IUGR babies and babies with a normal birth weight but with intrauterine Doppler alterations and abnormal CI should be closely followed to detect neurodevelopmental alterations during the postnatal period.
Ultrafast and Durable Lithium Storage Enabled by Porous Bowl‐Like LiFePO4/C Composite with Na+ Doping
Authors: Wang Boya , Wang Yan , Wu Hao , Yao Lei , Yang Li , Li Jianlong , Xiang Mingwu , Zhang Yun , Liu Heng 
Published: February 2017

AbstractPorous bowl‐like LiFePO4/C composites are prepared by using the ammonium salt and sodium salt processes with a facile precipitation method coupled with spray‐drying technology. Both of the as‐prepared LiFePO4/C composites present high crystallinity, bowl‐like morphology, and uniform carbon‐layer‐coated particles. Compared with the traditional ammonium salt process, the sodium salt process, without ammonia nitrogen pollutants, is not only environmentally friendly, but also allows us to introduce appropriate Na+ doping within the resultant LiFePO4. Moreover, the LiFePO4/C composite prepared by using the sodium salt process exhibits better electrochemical performance: a high rate capability (136, 129, and 119 mAh g−1 at 10, 20, and 40 C rate, respectively) and a long cycle stability (60.3 % of initial capacity after 3000 cycles at 10 C, only corresponding to 0.013 % capacity decay per cycle) compared with the other (only exhibits a capacity of 123, 107, and 62 mAh g−1 at rate of 10, 20, and 40 C and retains a 37.5 % of initial capacity after 3000 cycles at 10 C). This good electrochemical performance originates from its special morphology, high crystallinity, stable structure, and Na+ doping.
Conceptual Design of Highly Integrated Processes – Optimization of Dividing Wall Columns
Authors: Waltermann Thomas , Skiborowski Mirko 
Published: February 2017

AbstractProcess intensification provides a whole toolbox of innovative solutions for improved energy efficiency of chemical processes. However, evaluation of this potential is hampered by the unavailability of suitable models and design tools. Integrated processes like dividing wall columns either have to be mapped by available unit operation models or tailored equation‐based models have to be developed. The current article reviews available methods for conceptual design and optimization of dividing wall columns and provides a detailed comparison of two representative optimization approaches.
High Purity Oligomeric Oxymethylene Ethers as Diesel Fuels
Authors: Deutsch Diana , Oestreich Dorian , Lautenschütz Ludger , Haltenort Philipp , Arnold Ulrich , Sauer Jörg 
Published: February 2017

AbstractOligomeric oxymethylene dimethyl ethers (OMEn, CH3(OCH2)nOCH3, n = 1 – 5) are promising diesel fuels for the reduction of harmful emissions. If OMEs are produced from dimethoxymethane and trioxane, the resulting OME mixtures usually contain residual trioxane which appears, after rectification, in the OME2 fraction. To circumvent this obstacle, substoichiometric amounts of trioxane have been employed in OME synthesis. Thus, OME2 samples with high purity could be prepared. Physicochemical and fuel data of high purity OME2 and higher OMEs have been determined to supplement previously reported data.