bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A Rapid and Novel Method for the Synthesis of 5‐Substituted 1H‐Tetrazole Catalyzed by Exceptional Reusable Monodisperse Pt NPs@AC under the Microwave Irradiation.
Authors: Erken Esma , Esirden Ibrahim , Kaya Muharrem , Sen Fatih 
Published: December 2015

AbstractMonodispers platinum nanoparticles on activated carbon are found to be a superior, reusable, environmentally benign, and highly efficient heterogenous catalyst for the synthesis of the title tetrazoles by [3+2] cycloaddition reaction of aromatic nitriles with sodium azide.
ChemInform Abstract: A Novel and Facile Synthesis of 4‐Arylquinolin‐2(1H)‐ones under Metal‐Free Conditions.
Authors: Sun Bin , Mai Wen‐Peng , Yang Liang‐Ru , Mao Pu , Yuan Jin‐Wei , Xiao Yong‐Mei 
Published: December 2015

AbstractTitle compounds (II) are conveniently synthesized under metal‐free conditions and using inexpensive reagents.
ChemInform Abstract: A Unified Approach to the Four Azaindoline Families by Inter‐/Intramolecular Annulative Diamination of Vinylpyridines.
Authors: Danneman Michael W. , Hong Ki Bum , Johnston Jeffrey N. 
Published: December 2015

AbstractThe metal‐free oxidative amination procedure allows access to a series of products which include all azaindoline structures bearing an amino function at C‐3.
ChemInform Abstract: Ultrasound‐Promoted Green Approach for the Synthesis of Thiazoloquinolines Using Gold(III) Dipyridine Complex Immobilized on SBA‐15 as Nano Catalysts at Room Temperature.
Authors: Sadeghzadeh Seyed Mohsen 
Published: December 2015

AbstractThe new eco‐friendly catalyst can be easily recovered by filtration and reused for several times without significant loss of activity.
ChemInform Abstract: A Novel Method for the Synthesis of Imidazo[1,5‐b]pyridazines.
Authors: Vandyshev Dmitriy Yu. , Shikhaliyev Khidmet S. , Potapov Andrei Yu. , Krysin Mikhail Yu. 
Published: December 2015

AbstractThe title pyridazine derivatives are synthesized through a regioselective intramolecular cyclization mechanism.
ChemInform Abstract: Palladium‐Catalyzed Oxalyl Amide Directed Silylation and Germanylation of Amine Derivatives.
Authors: Chen Changpeng , Guan Mingyu , Zhang Jingyu , Wen Zhenkang , Zhao Yingsheng 
Published: December 2015

AbstractConditions for the ortho‐selective trimethylsilylation of oxalyl amide protected benzylamine and phenylethylamine derivatives are developed which tolerate a diverse range of functional groups.
ChemInform Abstract: Palladium‐Catalyzed Phosphonylation of Pyrazoles Substituted by Electron‐Withdrawing Groups
Authors: Huang Qi , Tran Gael , Gomez Pardo Domingo , Tsuchiya Tomoki , Hillebrand Stefan , Vors Jean‐Pierre , Cossy Janine 
Published: December 2015

Abstract19 examples
ChemInform Abstract: Fabrication and Application of Non‐Rare Earth Red Phosphors for Warm White‐Light‐Emitting Diodes.
Authors: Zhou Qiang , Zhou Yayun , Wang Zhengliang , Liu Yong , Chen Guo , Peng Jinhui , Yan Jing , Wu Mingmei 
Published: December 2015

AbstractRed phosphors K2XF6:Mn4+ (X: Si, Ti, Ge) are precipitated from a 40% aq.
ChemInform Abstract: 1,2,4‐Triazine Chemistry. Part 4. Synthesis and Chemical Behavior of 3‐Functionalized 5,6‐Diphenyl‐1,2,4‐triazines Towards Some Nucleophilic and Electrophilic Reagents
Authors: Abdel‐Rahman Reda M. , Makki Mohamed S. T. , Ali Tarik E. , Ibrahim Magdy A. 
Published: December 2015

AbstractReview: 80 refs.
STAT3‐Interacting Proteins as Modulators of Transcription Factor Function: Implications to Targeted Cancer Therapy
Authors: Yeh Jennifer E. , Frank David A. 
Published: December 2015

AbstractThe oncogenic transcription factor STAT3 is inappropriately activated in multiple hematopoietic and solid malignancies, in which it drives the expression of genes involved in cell proliferation, differentiation, survival, and angiogenesis. Thus far, strategies to inhibit the function of STAT3 have focused on blocking the function of its activating kinases or sequestering its DNA binding ability. A less well‐explored aspect of STAT3 function is its interaction with other proteins, which can modulate the oncogenic activity of STAT3 via its subcellular localization, DNA binding ability, and recruitment of transcriptional machinery. Herein we summarize what is currently known about STAT3‐interacting proteins and describe the utility of a proteomics‐based approach for successfully identifying and characterizing novel STAT3‐interacting proteins that affect STAT3 transcriptional activity and oncogenic function.
EPR Studies of V‐ATPase with Spin‐Labeled Inhibitors DCC and Archazolid: Interaction Dynamics with Proton Translocating Subunit c
Authors: Gölz Jan Philipp , Bockelmann Svenja , Mayer Kerstin , Steinhoff Heinz‐Jürgen , Wieczorek Helmut , Huss Markus , Klare Johann P. , Menche Dirk 
Published: December 2015

AbstractVacuolar‐type H+‐ATPases (V‐ATPases) have gained recent attention as highly promising anticancer drug targets, and therefore detailed structural analyses and studies of inhibitor interactions are very important research objectives. Spin labeling of the V‐ATPase holoenzyme from the tobacco hornworm Manduca sexta and V‐ATPase in isolated yeast (Saccharomyces cerevisiae) vacuoles was accomplished by two novel methods involving the covalent binding of a (2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl (TEMPO) derivative of N,N′‐dicyclohexylcarbodiimide (DCC) to the essential glutamate residue in the active site and the noncovalent interaction of a radical analogue of the highly potent inhibitor archazolid, a natural product from myxobacteria. Both complexes were evaluated in detail by electron paramagnetic resonance (EPR) spectroscopic studies and double electron–electron resonance (DEER) measurements, revealing insight into the inhibitor binding mode, dynamics, and stoichiometry as well as into the structure of the central functional subunit c of these medicinally important hetero‐multimeric proton‐translocating proteins. This study also demonstrates the usefulness of natural product derived spin labels as tools in medicinal chemistry.
Analytical and diagnostic validation of a flow cytometric strategy to quantify blood and marrow infiltration in dogs with large B‐cell lymphoma
Authors: Riondato Fulvio , Miniscalco Barbara , Poggi Alessia , Aricò Arianna , Aresu Luca , Comazzi Stefano , Martini Valeria 
Published: December 2015

BackgroundLymph node (LN), peripheral blood (PB), and bone marrow (BM) samples are commonly analyzed by flow cytometry (FC) for the immunophenotyping and staging of canine lymphomas. A prognostic value for FC BM infiltration in dogs with large B‐cell lymphoma (LBCL) was demonstrated. Aim of this study was to define the analytical performances of this technique, and to establish a cutoff suitable to safely discriminate between infiltrated and noninfiltrated PB and BM samples.MethodsLarge B‐cells were added to control PB and BM samples, to achieve twelve different large B‐cells concentrations, ranging from 0 to 50%. The percentage of large B‐cells was recorded for each dilution, using a BD Accuri C6 FC. Accuracy was evaluated by Passing‐Bablok regression analysis. Intra‐assay precision was assessed at 0%, 1, 3, and 10% dilutions evaluating the CVs of 10 repeated acquisitions. ROC curves were drawn to identify the cutoffs most suitable to discriminate between 25 infiltrated (PARR‐positive) and 25 noninfiltrated (PARR‐negative) PB and BM samples, respectively.ResultsOptimal analytical accuracy and precision were achieved. Almost all CVs were <10%. Negative controls had up to 0.5% large B‐cells, with 50 and 22% CV in PB and BM samples, respectively, 0.56 and 2.45% cutoffs were selected based on the ROC curves for PB and BM samples, respectively.ConclusionsQuantification of large B‐cells in PB and BM samples by FC is reliable and analytical performances met the acceptance criteria. Assessment of performances of different instruments and protocols is warranted. © 2016 International Clinical Cytometry Society
Simultaneous measurement of human hematopoietic stem and progenitor cells in blood using multicolor flow cytometry
Authors: Cimato Thomas R. , Furlage Rosemary L. , Conway Alexis , Wallace Paul K. 
Published: December 2015

Hematopoietic stem cells are the source of all inflammatory cell types. Discovery of specific cell surface markers unique to human hematopoietic stem (HSC) and progenitor (HSPC) cell populations has facilitated studies of their development from stem cells to mature cells. The specific marker profiles of HSCs and HSPCs can be used to understand their role in human inflammatory diseases.The goal of this study is to simultaneously measure HSCs and HSPCs in normal human venous blood using multicolor flow cytometry. Our secondary aim is to determine how G‐CSF mobilization alters the quantity of each HSC and HSPC population. Here we show that cells within the CD34+ fraction of human venous blood contains cells with the same cell surface markers found in human bone marrow samples. Mobilization with G‐CSF significantly increases the quantity of total CD34+ cells, blood borne HSCs, multipotent progenitors, common myeloid progenitors, and megakaryocyte erythroid progenitors as a percentage of total MNCs analyzed. The increase in blood borne common lymphoid and granulocyte macrophage progenitors with G‐CSF treatment did not reach significance. G‐CSF treatment predominantly increased the numbers of HSCs and multipotent progenitors in the total CD34+ cell population; common myeloid progenitors and megakaryocyte erythroid progenitors were enriched relative to total MNCs analyzed, but not relative to total CD34+ cells. Our findings illustrate the utility of multicolor flow cytometry to quantify circulating HSCs and HSPCs in venous blood samples from human subjects. © 2016 International Clinical Cytometry Society
Exploring the Colour of 3d Transition‐Metal Ions in Trigonal Bipy­ramidal Coordination: Identification of Purple‐Blue (CoO5) and Beige‐Red (NiO5) Chromophores in LiMgBO3Host
Authors: Tamilarasan Subramani , Laha Sourav , Natarajan Srinivasan , Gopalakrishnan Jagannatha 
Published: December 2015

AbstractIn an attempt to develop new coloured inorganic oxides, we have investigated the substitution of 3d transition‐metal ions in LiMgBO3host [where MgIIhas a trigonal bipyramidal (TBP) oxygen coordination]. We find that single‐phase materials are formed for LiMg1–xCoIIxBO3(0 <x≤ 1.0), LiMg1–xNiIIxBO3(0 <x≤ 0.1), LiMg1–xCuIIxBO3(0 <x≤ 0.1) and also Li1–xMg1–xFeIIIxBO3(0 <x≤ 0.1) of which the CoIIand NiIIderivatives are strongly coloured, purple‐blue and beige‐red, respectively, thus identifying TBP CoO5and NiO5as new chromophores for these colours.
Synthesis of 3‐Substituted 2‐Indol­inones by a Multicomponent Coupling Isocyanide‐Dependent Microwave‐Assisted Intramolecular Transamidation Process
Authors: Maddirala Amarendar Reddy , Andreana Peter R. 
Published: December 2015

AbstractA small‐molecule library synthesis of 3‐substituted 2‐indolinones using methyl isocyanide and a microwave‐assisted intramolecular transamidation process with 10 % TFA in dichloroethane has been achieved in 3 steps. A modified Fe0 Bechamp‐type reduction of a substituted bifunctional substrate, o‐nitrobenzaldehyde, renders 3‐substituted 2‐indolinones in yields ranging from 76–91 % (21 examples). Furthermore, it has been determined that symmetrical 2o N‐alkyl or aryl substituents, as a component of the amine starting material, suppresses 3‐substituted 2‐indolinone rotameric mixtures and allows for facile compound 1H NMR characterization. In the absence of methyl isocyanide, 3,4‐dihydroquinazolines or transamidation products predominate under both Brønsted or Lewis acid conditions in reasonable yields.
Research‐on‐Evaluation Articles Published in the American Journal of Evaluation, 1998–2014
Authors: Vallin Lisa M. , Philippoff Joanna , Pierce Sena , Brandon Paul R. 
Published: December 2015

AbstractProminent evaluators have advocated over the years for research on evaluation (RoE), yet to our knowledge, studies about the number and percentage of RoE studies that have been published do not exist. In this chapter, we present a summary of the RoE articles, categorized by several descriptive characteristics, that have been published in the American Journal of Evaluation (AJE), the flagship journal of the American Evaluation Association. We show that (a) about half of AJE articles can be considered RoE, (b) the percentage per year tended to increase through 2011, (c) half of the RoE articles addressed evaluation independent of a professional domain, (d) about one‐third were single case studies or surveys, and (e) the topics of the research have varied considerably. We conclude by arguing for continued documentation of RoE and for the development of an electronic database for evaluators seeking empirical evidence to address common evaluation issues.
Advancing Research on Evaluation Through the Study of Context
Authors: Vo Anne T. , Christie Christina A. 
Published: December 2015

AbstractThe importance of context in shaping evaluation practice is broadly accepted. Still, there is much to be learned about context, and we remain at the early stages of this process. In this chapter, we describe a framework for organizing and focusing ideas for conducting research on evaluation context. We hope that this tool will be a source of inspiration for future studies of context, thus contributing to a deeper and higher quality evaluation knowledge base.
Evaluators’ Perspectives on Research on Evaluation
Authors: Lewis Nicole R. , Harrison George M. , Ah Sam Anna F. , Brandon Paul R. 
Published: December 2015

AbstractProgram evaluators are giving increasing attention to research on evaluation (RoE), but little is known about their perceptions of RoE. In this chapter, we report the methods and results of a questionnaire survey that drew from the Theory of Planned Behavior and addressed a broad swath of evaluators’ attitudes toward, beliefs about, and knowledge of RoE; time and opportunities to participate in RoE; application of RoE findings; and involvement in RoE. The results show that evaluators (a) believe RoE is important, (b) report a moderate degree of access and opportunities to read or use the RoE literature, (c) have little time and few opportunities to conduct RoE, (d) report knowing enough about RoE to attend presentations but lack the knowledge to conduct RoE, and (e) describe little involvement in conducting RoE. University faculty, those with doctorates, and those with an advanced level of understanding of evaluation report the greatest participation in RoE. These results confirm our sense of current perceptions about evaluators’ participation in various RoE activities and set the stage for developing steps to encourage RoE in its various manifestations.
Longitudinal assessment of white matter abnormalities following sports‐related concussion
Authors: Meier Timothy B. , Bergamino Maurizio , Bellgowan Patrick S. F. , Teague T. K. , Ling Josef M. , Jeromin Andreas , Mayer Andrew R. 
Published: December 2015

AbstractThere is great interest in developing physiological‐based biomarkers such as diffusion tensor imaging to aid in the management of concussion, which is currently entirely dependent on clinical judgment. However, the time course for recovery of white matter abnormalities following sports‐related concussion (SRC) is unknown. We collected diffusion tensor imaging and behavioral data in forty concussed collegiate athletes on average 1.64 days (T1; n = 33), 8.33 days (T2; n = 30), and 32.15 days post‐concussion (T3; n = 26), with healthy collegiate contact‐sport athletes (HA) serving as controls (n = 46). We hypothesized that fractional anisotropy (FA) would be increased acutely and partially recovered by one month post‐concussion. Mood symptoms were assessed using structured interviews. FA differences were assessed using both traditional and subject‐specific analyses. An exploratory analysis of tau plasma levels was conducted in a subset of participants. Results indicated that mood symptoms improved over time post‐concussion, but remained elevated at T3 relative to HA. Across both group and subject‐specific analyses, concussed athletes exhibited increased FA in several white matter tracts at each visit post‐concussion with no longitudinal evidence of recovery. Increased FA at T1 and T3 was significantly associated with an independent, real‐world outcome measure for return‐to‐play. Finally, we observed a nonsignificant trend for reduced tau in plasma of concussed athletes at T1 relative to HA, with tau significantly increasing by T2. These results suggest white matter abnormalities following SRC may persist beyond one month and have potential as an objective biomarker for concussion outcome. Hum Brain Mapp 37:833–845, 2016. © 2015 Wiley Periodicals, Inc.
Tumor volume as a predictor of survival in human papillomavirus–positive oropharyngeal cancer
Authors: Davis Kara S. , Lim Chwee Ming , Clump David A. , Heron Dwight E. , Ohr James P. , Kim Seungwon , Duvvuri Umamaheswar , Johnson Jonas T. , Ferris Robert L. 
Published: December 2015

AbstractBackgroundIncreasing evidence exists that tumor volume may be a superior prognostic model than traditional TNM staging. It has been observed that oropharyngeal squamous cell carcinoma (oropharyngeal SCC) in the setting of human papillomavirus (HPV) positivity have a greater propensity for cystic nodal metastases, and, thus, presumably larger volume with relatively smaller primary tumors. The influence of HPV status on the predictive value of tumor volume is unknown.MethodsFifty‐three patients with HPV‐positive oropharyngeal SCC were treated with definitive chemotherapy and intensity‐modulated radiotherapy (IMRT).ResultsThe estimated 2‐year overall survival (OS) and disease‐free survival (DFS) was 92.2% and 83.6%, respectively. Nodal classification did not predict OS (p = .096) or DFS (p = .170). Similarly, T classification did not predict OS (p = .057) or DFS (p = .309). Lower nodal volume was associated with greater DFS (p = .001).ConclusionNodal tumor volume was found to be predictive of DFS. DFS was best predicted by nodal gross tumor volume (GTV) at 24 months. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1613–E1617, 2016
Sinonasal mucosal melanoma: A 12‐year experience of 58 cases
Authors: Lombardi Davide , Bottazzoli Marco , Turri–Zanoni Mario , Raffetti Elena , Villaret Andrea Bolzoni , Morassi Maria Laura , Ungari Marco , Vermi William , Battaglia Paolo , Castelnuovo Paolo , Facco Carla , Sessa Fausto , Donato Francesco , Nicolai Piero 
Published: December 2015

AbstractBackgroundSinonasal mucosal melanoma is a rare malignancy with poor prognosis.MethodsPatients with sinonasal malignant melanoma who underwent surgery by different approaches were included in this study. Overall survival (OS) and event‐free survival were calculated, and statistically significant variables by univariate analysis were entered in a multivariate Cox regression model.ResultsPathological staging was pT3, pT4a, and pT4b in 30 cases (51.7%), 17 cases (29.3%), and 11 cases (19.0%). At 3 and 5 years, OS was 43.5% and 29% and event‐free survival was 23.6% and 12.4%, respectively. At univariate analysis, OS was significantly influenced by male sex, advanced pT classification, positive margins, and surgical approach; event‐free survival was affected by positive margins. At multivariate analysis, the risk of death was independently associated with male sex (hazard ratio [HR] = 2.27; p = .04) and positive margins (HR = 2.32; p = .03).ConclusionMale sex and positive margins were negative prognostic factors. Endoscopic resection did not show an increased risk of death compared with more extensive surgical approaches. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1737–E1745, 2016
Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long‐term potentiation in the mouse hippocampus
Authors: Li Yong , Kim Jimok 
Published: December 2015

ABSTRACTThe effects of cannabinoids are mostly mediated by two types of cannabinoid receptors—CB1 receptors in the nervous system and CB2 receptors in the immune system. However, CB2 cannabinoid receptors have recently been discovered in the brain and also implicated in neurophysiological functions. The deletion of CB2 receptors in mice induces long‐term memory deficits and schizophrenia‐like behaviors, implying that endogenous activity of CB2 receptors might be involved in neuropsychiatric effects. Little is known about the cellular mechanisms by which physiological activation of CB2 receptors modulates neuronal functions. We aimed to determine how deletion of CB2 receptors in mice affects synaptic transmission and plasticity. Electrophysiological and morphological studies indicated that CB2 receptor knockout resulted in decreases in excitatory synaptic transmission, long‐term potentiation, and dendritic spine density in the hippocampus. Our data imply that endogenous activity of CB2 receptors might contribute to the maintenance of synaptic functions and the expression of normal long‐term potentiation. This study provides insights into the role of CB2 cannabinoid receptors in regulating cognitive functions such as long‐term memory. © 2016 Wiley Periodicals, Inc.
Evaluation of hepatic vascular endothelial injury during liver storage by molecular detection and targeted contrast‐enhanced ultrasound imaging
Authors: Xie Fang , Zhang Shu‐Hua , Cheng Jia , Wang Hong‐Wei , Fei Xiang , Jiao Zi‐Yu , Tang Jie , Luo Yu‐Kun 
Published: December 2015

AbstractWe hypothesized that lack of the high‐energy phosphates during liver storage may potentially cause persistent injury to the vascular endothelium. Biopsies were obtained from livers obtained from beating heart human donors, stored either in the standard storage solution, that is, University of Wisconsin solution (UWS) or Celsior, and examined for various markers related to progressive endothelial injury. The expression of P2Y1 receptor, the major signal transduction machinery for adenosine triphosphate/adenosine diphosphate, decreased in hepatic vascular endothelial cells over time. Despite unaltered endothelial nitric oxide synthase (eNOS) levels, serine1177‐phosphorylated eNOS, the active form of eNOS, progressively decreased with time. The production of nitric oxide enzyme decreased with time when liver tissues were examined in vitro. This also coincided with decreased interaction of eNOS with actin nucleating proteins like myristoylated alanine‐rich C kinase substrate and Rac1, which plays a role in modulating the cytoskeleton and helps position eNOS in a favorable cytosolic position for active enzymatic activity. Conversely, the interaction of eNOS with caveolin1 was significantly increased 6 H after ex vivo storage. Finally, we demonstrated by targeted contrast‐enhanced ultrasound that membrane‐bound vascular cell adhesion molecule‐1 in the hepatic vascular endothelial cell increased after 6 H of ex vivo storage. Overall, the results of this study provide evidence of a progressive hepatic vascular endothelial injury during the ex vivo storage. This may be a causative factor for ischemic cholangiopathy and delayed graft function post liver transplantation. © 2015 IUBMB Life, 68(1):51–57, 2015