bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Ascorbic Acid on Tax, NF-κB and MMP-9 in Human T-cell Lymphotropic Virus Type 1 Positive Malignant T-Lymphocytes
Authors: Harakeh Steve , Khalife Jihane , Baydoun Elias , Azar Rania , Al- Hejin Ahmed , Barbour Elie , Azhar Esam , Niedzwiecki Aleksandra , Al Jaouni Soad , Diab-Assaf Mona , Kamal Mohammad A. , Rath Mathias 
Published: July 2017

Background:
HTLV1 is a retrovirus that infects CD4-positive cells and leads to Adult T-cell leukemia
by constitutive activation of nuclear factor kappa B. Ascorbic acid (AA) is an essential nutrient that possess
anti-proliferative and pro-apoptotic activity against a number of malignant cell lines. This study delineates the
effect of AA on Tax protein expression as well as NF-κB and MMP9 activity in two HTLV1-positive leukemia
cells (HuT-102 and C91-PL).

Methods:

The cytotoxic and antiproliferative effect of AA were studied by LDH release and MTT tests, respectively.
The proteins expression level was assessed by western blotting. RT-PCR was used to study mRNAs
level. Finally, ELISA/EMSA and Zymography were used to evaluate NF-κB and MMP-9 activities, respectively.

Results:

Cell lines were treated with non-cytotoxic concentrations of AA for 48h and 96h, which resulted in a
significant inhibition of proliferation at a concentration of 50µg/ml at 96h in both cell lines. The same concentration
inhibited Tax protein expression as well as the NF-κB nuclearization and DNA binding activity. The
inhibitory effect of AA on MMP9 protein expression and activity started at 100µg/ml and 50µg/ml in HuT-102
and C91-PL cells respectively, with no effect at the transcriptional levels of MMP-9 in either one of the two cell
lines.

Conclusion: These results indicated that while AA exerted its anti-proliferative effect on the NF- κB activation
pathway by suppressing Tax expression, its effects on MMP9 seemed to be independent of this mechanism and
follow a different approach.
Anethole Inhibits the Proliferation of Human Prostate Cancer Cells via Induction of Cell Cycle Arrest and Apoptosis
Authors: Elkady Ayman I. 
Published: July 2017

Background:
Prostate cancer-associated mortality is increasing at an alarming rate, which highlights
the inevitability for unearthing novel agent for the management of this disease. Anethole, a major constituent of
Foeniculum vulgare (fennel) essential oil, is widely used in folk medicine; it possesses anti-oxidant, antiinflammatory,
anti-proliferative and tumoricidal potentialities.

Objective:
The current research was conducted to assess the impact of anethole on prostate cancer cell line, PC-
3, and to delineate the molecular mechanism of action.

Methods:
To achieve this aim, the growth-inhibitory effect of anethole was evaluated by MTT assay. Apoptotic
death and cell cycle analyses were assessed by flow cytometry and alterations in gene expression were investigated
by qPCR and Western blot analyses.

Results:
The observations indicated that anethole inhibited proliferation, clonal growth and migration of PC-3
cells. It also suppressed growth of PC-3 derived cancer stem cells (tumorspheres). Pro-apoptotic potential of
anethole was accompanied by generation of ROS, permeabilization of the mitochondrial and lysosomal membranes,
activation of caspase-3 and -9, DNA damage, PARP cleavage and induction of Bax/Bcl-2 protein ratio.
Further, anethole induced G2/M phase arrest, downregulation of cyclins D1, CDK-4 and c-Myc proteins and
upregulation of p21 and p27. Anethole suppressed nuclear localization of NF-κB protein and downregulated
transcription of NF-κB-dependent genes.

Conclusion:
Overall, the above findings highlight the effectiveness of anethole as a potential candidate for
prostate cancer therapy.
Relationship between Capillary Refill Time at Triage and Abnormal Clinical Condition: A Prospective Study
Authors: Sansone Claudia M. , Prendin Fabiano , Giordano Greta , Casati Paola , Destrebecq Anne , Terzoni Stefano 
Published: July 2017

Background:
Capillary refill time has been studied in literature as a perfusion indicator. Two pilot studies have proposed possible reference values in healthy adults. No data exist regarding capillary refill time as an indicator of abnormal clinical conditions in adults, which might be of help for triage nurses.

Objective:
We wanted to assess if any relationships existed, between altered capillary refill time and abnormal clinical conditions in the emergency department. We investigated relations between capillary refill time and vital signs recorded in triage and blood tests, by analyzing the clinical records. Mortality at 24 hours, 7 days and over 14 days was investigated by calling the patients after discharge.

Method:
Observational, single-center study on a sample of consecutive patients aged ≥ 18 years in the Emergency Department of a major Milan hospital, from June to October 2014. Multivariate logistic regression was used to investigate the impact of clinical variables on capillary refill time.

Results:
1001 patients were enrolled, aged 59 ± 21 (473 aged 65 or more). Longer refill times were found in patients admitted to hospital units after medical consultations in the emergency department compared to those discharged or sent to outpatients. In elderly patients, statistically significant association was found between increased capillary refill time and sepsis (sensitivity 100%, specificity 83.33%, area under the receiver operating characteristics curve 65.95% CI 47-83), oxygen saturation, mean blood pressure, and lactates. In persons aged 45 to 64, altered refill times were associated with abnormal values of glicemia, platelets, and urea.

Conclusion:
Capillary refill time can be used by nurses at triage as a complementary parameter to normal vital signs. This is one of the few studies investigating refill time in adult patients.
Predictions of Diffuse Pollution by the HSPF Model and the Back‐Propagation Neural Network Model
Authors: Chang Chia‐Ling , Li Meng‐Yuan 
Published: July 2017

ABSTRACT: Watershed models are important tools for predicting the possible change of watershed responses. Environmental models comprise the deterministic model and the probabilistic model. This study discusses the Hydrological Simulation Program Fortran (HSPF) and the Back‐Propagation Neural Network (BPNN); these two models represent the deterministic model and the probabilistic model, respectively. As the properties of the two models are distinct, they have differing abilities to predict surface‐runoff pollution. For the two models, the runoff simulation results are satisfactory. However, due to the limitation of the water quality monitoring records, pollution simulation is more difficult than runoff simulation. The results indicate that the prediction accuracy in the pollution simulation can be improved by adjusting the BPNN neurons. On the contrary, improving the prediction accuracy is limited by HSPF. Although the flexibility of BPNN is higher than HSPF, sufficient historical monitoring records are important for both of these models.
Performance Evaluation of Membrane‐Based Septic Tank and Its Reuse Potential for Irrigating Crops
Authors: Khalid Mehwish , Hashmi Imran , Khan Sher Jamal 
Published: July 2017

ABSTRACT: Membrane technology, being the most emerging wastewater treatment option, has gained substantial importance with the massive objective of the reuse potential of wastewater. Keeping this in view, the present study was conducted with the rationale to evaluate the performance efficiency of membrane‐based septic tank (MBST), and its reuse perspective for irrigating crops. The septic tank was designed by submerging a woven fiber microfiltration membrane module to treat domestic wastewater. Three crops Triticum aestivum (wheat), Coriandrum sativum (coriander), and Mentha arvensis (mint) were selected to be irrigated with treated MBST effluent, untreated wastewater, and tap water (as a control) for comparative growth analysis. Two pathogenic strains, Escherichia coli and Salmonella sp. were selected as reference microbes and their translocation rate was observed in root, shoot, and leaves. Upon maturity, the roots, shoots, and leaves of the above‐mentioned plants were aseptically removed for microbiological analysis. Strains were analyzed, using analytical profile index and PCR analysis. Maximum removal efficiencies for MBST in terms of chemical oxygen demand (COD), turbidity, nutrients deduction (phosphorus), and indicator bacteria (Escherichia coli) were found to be 73, 96, 48, and 88%, respectively. Significant bacterial load reduction (p < 0.001) in terms of E. coli (3.8 log CFU/100 mL) and helminths (2 eggs/L) was observed in treated water. High plant yield was observed when irrigated with treated water as compared to tap water, as minimal nutrient removal (48%) was recorded in treated water, with the germination percentage of 88.8%.
A SOLUTION TO THE FINGERING PROBLEM OF BRAHMS CELLOS SONATA NO.1 OPUS 38 AND SHOSTAKOVICH CELLO SONATA OPUS 40
Authors: Wirayudha Asep Hidayat 
Published: July 2017

Tulisan ini lahir dari permasalahan yang dihadapi penulis ketika memainkan Sonata Cello No. 1 op.38 karya Johanes Brahms dan Sonata Cello Op 40 karya Shostakovich. Persoalan ini sering juga dihadapi dalam memainkan beberapa komposisi. Pendalaman pokok permasalahan tersebut mendorong penulis untuk merumuskan kedalam dua pokok permasalahan, yaitu permasalahan Oktav dan Jarak Interval. Dalam hal ini permasalahan tersebut berhubungan erat dengan struktur penjarian secara anatomis penulis sendiri. Pencarian solusi permasalahan tersebut menjadi penelitian tersendiri dan selanjutnya menjadi hal yang penting bagi penulis untuk dapat berbagi pengalaman yang dijadikan studi bersama. Tulisan ini mengutamakan siasat baru mengenai kemampuan tekhnis memainkan interval dan oktav dan persoalan jarak interval dalam kontek Sonata
PEMGEMBANGAN MEDIA PEMBELAJARAN PRAKTEK TARI SURAKARTA I BAGI MAHASISWA JURUSAN PENDIDIKAN SENI TARI FAKULTAS BAHASA DAN SENI UNIVERSITAS NEGERI YOGYAKARTA
Authors: Herlinah - 
Published: July 2017

Penelitian ini bertujuan untuk menghasilkan produk media video pembelajaran tari yang bisa digunakan untuk menunjang pembelajaran mata kuliah Tari Surakarta I bagi mahasiswa Jurusan Pendidikan Seni Tari Fakultas Bahasa dan Seni Universitas Negeri Yogyakarta. Kompetensi yang ingin dicapai melalui media pembelajaran ini adalah meningkatnya teknik gerak, wirama, dan penjiwaan mahasiswa. Pengembangan video pembelajaran tari Surakarta I ini menggunakan model prosedural dengan 8 tahap pokok, yaitu: (1) analisis kebutuhan, (2) perancangan, (3) pengembangan produk awal, (4) uji validasi ahli, (5) uji coba terbatas, (6) revisi 1 (7) uji coba lapangan, dan (8) evaluasi akhir. Setelah melalui proses pengembangan produk yaitu melalui uji ahli dan uji coba terbatas diperoleh media video pembelajaran tari. Persepsi mahasiswa tentang kemampuan media untuk meningkatkan motivasi belajar dan pemahaman teknik gerak, irama, ekspresi dan penjiwaan tari adalah sebagai berikut: Perolehan skor persepsi mahasiswa tentang kemampuan media dalam meningkatkan motivasi belajar adalah: 4,25; pemahaman teknik gerak 4,8; pemahaman irama 4, 25; pemahaman ekspresi dan penjiwaan 4. Sedangkan dari segi teknis, persepsi mahasiswa tentang kualitas peraga yang dipergunakan adalah 4,05; kualitas gambar 3,65; kualitas suara 3,8; dan kebermaknaan materi 4,35. Rata-rata skor keseluruhan adalah 4,14. Berdasarkan perolehan skor maka dapat disimpulkan bahwa persepsi mahasiswa tentang kemampuan dan kualitas media video tari Gambyong Pareanom secara keseluruhan adalah baik.
PATUNG TAU TAU DI TORAJA PROVINSI SULAWESI SULAWESI SELATAN: Kajian Simbol Susanne Knauth Langer
Authors: Suherman - 
Published: July 2017

Patung Tau Tau di Toraja, Sulawesi Selatan merupakan salah satu karya seni yang tergolong dalam karya seni ritual. PatungTau Tau adalah replika dari masyarakat Toraja yang meninggal dunia.Patung Tau Tau sebagai karya seni ritual, oleh karena Patung Tau Tau erat kaitannya dengan proses ritual keagamaan. Dalam kepercayaan suku adat Toraja (Aluk Todolo), Tau Tau bukan melambangkan badan atau raga almarhum, melainkan simbol roh atau spirit sang almarhum yang tidak ikut mati, tetapi melanjutkan kehidupan lain di alam berikutnya sesudah kematian. Kehadiran seni dalam ritual agama, menjadi satu kesatuan yang akrab, sebagaimana kegiatan itu disamping pengalaman keimanan, sekaligus juga pengalaman estetis. Berdasarkan pemahaman bahwa manusia berfikir, berperasaan, dan bersikap dalam ungkapan-ungkapan simbolis,sebagaimana Susanne Knauth Langer (1895-1985) yang pernah menjadi murid Ernest Cassirer, bahwa simbolisme merupakan ciri khas bagi manusia yang dengan terang membedakannya dengan hewan.
“JOKI KECIL”: FAKTA DAN FIKSI DALAM SUDUT PANDANG KOGNITIF
Authors: Vulkanita Hasan Renta , Raharsono A. Lilik Slamet 
Published: July 2017

“Joki Kecil” (Yuli Andari, 2005) peneliti anggap sebagai film dokumenter yang menarik untuk dikaji dalam konteks disposisi kebenaran dokumenter.Kebenaran menjadi istilah yang peneliti pilih karena menurut peneliti, sampai saat ini masih terdapat problem yang mempermasalahkan sisi “kebenaran” pada dokumenter.Dalam tinjauan awal ini, peneliti memposisikan diri sebagai penonton, baik secara aktual (bertindak sebagai konsumen film pada umumnya, duduk dan menikmati setiap jalan cerita yang disajikan) dan secara kontekstual (bertindak sebagai seseorang yang sedang mencari kebenaran dalam sebuah dokumenter dengan bekal pertanyaan teoretis pada wilayah kajian dokumenter), melalui pengalaman faktual dan imajinasi saat menonton dokumenter itu.Persamaan dan perbedaan menjadi dua kelompok penting dalam mengungkap kebenaran dalam dokumenter yang ditonton. Melalui persamaan dan perbedaan, penonton akan menggunakan struktur mental untuk menjelaskan mengapa proses mental dan pemahaman seseorangtentang duniamemiliki stabilitas dan keteraturan seperti yang orang lain lakukan dan mengapa dunia fenomenaldalam banyak kasus nampak terlihat berbeda dari "dunia nyata."
THE INQUIRY TRAINING LEARNING MODEL USE MIND MAPPING AND FORMAL THINGKING ABILITY ON STUDENT’S SCIENCE PROCESS SKILLS
Authors: Anggraini Bima 
Published: July 2017

The aim of this research were to analyzes: the different students’s science process skills by using inquiry training learning model and using conventional learning, the different students’s science process skills in the group of students who had formal thinking ability above average and below average, and the interaction inquiry training learning model and conventional learning with formal thinking ability of the students’s science process skills. This research carried out by a quasi-experimental with using two group pretest-postest design. The population of this study was class IX SMP IT An-Nizam Medan. The sample in this research was conducted by cluster random sampling of two classes, experiment class by using inquiry training learning model and control class by using conventional learning. The instruments of this study used science process skills in the perform work form and formal thinking ability test were collected by essay test. The data was analyzed by using two-way analysis of varians. The results of this research are the different students’s science process skills of inquiry training learning model and conventional learning, the different students’s science process skills who had formal thinking ability above average and below average, and there were an interactions between the inquiry training learning model with formal thinking ability in improving students's science process skills.
THE EFFECTS OF COOPERATIVE LEARNING MODEL GROUP INVESTIGATION TOWARD TEAMWORK ABILITY AND LEARNING OUTCOMES ON STUDENTS PHYSICS
Authors: Silviana Fitria 
Published: July 2017

This study aims: 1) to determine differences in science process skills of students with This study aims to determine: teamwork ability of students with cooperative learning model of type of group investigation and the ability to work with students with conventional learning, the effect of cooperative learning model of group investigation on learning outcomes of students in learning physics., correlation between the ability of teamwork and learning outcomes students. This research uses type of quasi-experimental with two group pretest-posttest design. The study population was standard X SMA.Negeri 1 Langsa.The sample of this research were the students of X.10 as experiment group and X.9 as control group that established by purpossive sampling. The instruments used consist of observation sheets of teamwork and essay test of learning outcomes. The data were analyzed using parametric t-test analysis. The results showed that: The teamwork ability of students who are taught by cooperative learning model type group investigation better than students taught by conventional teaching in physics learning, cooperative learning model of type of group investigation has effect on student learning outcomes. Learning outcomes of students taught by cooperative learning model of type of group investigation better than on learning outcomes for students who taught by conventional learning, and there is a correlation between the teamwork ability with student learning outcomes.
THE EFFECT OF COOPERATIVE LEARNING MODEL GROUP INVESTIGATION AGAINST STUDENT LEARNING OUTCOMES PHYSICS VIEWED FROM THE ADVERSITY QUOTIENT
Authors: Lubis Rajo Hasim 
Published: July 2017

This study aims to determine: learning outcomes physics students with cooperative learning model GI and conventional learning, learning outcomes physics students who have Adversity Quotient (AQ) high and medium AQ and interaction cooperative learning model GI and AQ in affecting learning physics students. This quasi-experimental study using pretest-posttest control group design. The sample in this research is class X IPA.4 as an experimental class and class X IPA.3 as the control class is selected by simple random sampling. The instrument used is the achievement test and which AQ questionnaire form. Data was analyzed using two ways ANOVA. The results shows that: learning outcomes physics students with cooperative learning model GI better than conventional learning, learning outcomes physics students who have a high AQ better than students who have a medium AQ and there is interaction between cooperative learning model GI and AQ in influencing physics student learning outcomes.
Metode Penyuluhan Dalam Adopsi Inovasi Inseminasi Buatan (Ib) Pada Usaha Peternakan Sapi Di Kabupaten Dharmasraya
Authors: Ediset Ediset , Jaswandi Jaswandi 
Published: July 2017

This research was conducted in the area Dharmasraya Regency, West Sumatra Province. The purpose of this study determined : a) Method of extention in innovation adoption of artificial insemination (AI) in the cattle farm in the District Dharamasraya, and b) Social and economic factors that influence adoption of innovation Artificial Insemination (AI) in the cattle farm in the District Dharmasraya. This research used survey method and approach to the analysis of secondary data. The number of samples in this study were determined by quota sampling technique by reason of homogeneous samples, the farmers were already adopting innovations and cattle ranchers IB program participants snapping Birahi Artificial Insemination (GBIB) thus took a sample of 40 people. The data collected were primary data with the help of question naires and secondary data with the literature study and related agencies. Descriptive analysis of quantitative data which was calculated using a Likert scale. The results showed that the extension method in the adoption of IB in cattle breeding business in the Regency Dharmasraya been implemented, namely the extension methods home and farm visits with category, extension methods demonstrations by both categories, and the campaign extension methods with the medium category. Social and economic aspects such as business scale farmers, revenue, risk, active participation in the innovation adoption had no effect on aspects of the IB whereas age despite being influential in the adoption of innovation, but still in the category of less influential.
Generation and Storage of Green Hydrogen and its Application for PEM Fuel Cells.
Authors: J.J. San Martín Díaz  , E. Romero García  , J. Zuazua Ojanguren  , D. Romero García  , V. Aperribay Maiztegui  , J.I. San Martín Díaz  , J.M. Arrieta Albizu  , I. Martín Amundarain  
Published: July 2017

The object of this communication is to show to the application of a new tool learning multimedia in which it talks about the green Hydrogen generation, that is to say, the obtained one from renewable energies (in our case of photovoltaic origin) and to their storage, for its later use in the feeding of a standard fuel battery PEM. The novel aspect that is tried to expose is that the knowledge acquired on the part of the user can be resisted by means of the accomplishment of the virtual practices available in the course, cradles by proving stand VENTUS Professional Science.
Modelling of clustered distributed generation for economic requirements.
Authors: M. Neubert  , G. Balzer  
Published: July 2017

In this paper, economical and technicalconsiderations of distributed generation units (DGU)will be presented in two steps. The first one analyseseconomic side of the distributed generation units. Thecalculation of total cost as well as the specific generationcost will be presented. The last newly defined param-eter allows to compare different distributed generationunits with their own and with traditional thermal powerplants. In the second step, the technical restrictionslike power stability or load flow will be considered. Todo this, the model of a low voltage (LV) network hasbeen created. The network has been divided into clus-ter, where DGU and loads are included. The DGU willbe driven in two operating modes: firstly variable loadaccording to the load curve and secondly with full load.Bringing these two models together the following con-clusion will be drawn. The use of distributed generationunits cannot be considered only from the technical pointof view. The economic view plays also an important role.
Interharmonics injected into power system by a squirrel-cage induction machine in normal and faulty operation conditions.
Authors: Jan Rusek  
Published: July 2017

The paper aims at examining interharmonics injected into the power supply system by a healthy and faulty squirrel cage induction machine operated at steady state. The faulty operation discussed encompasses breaks in squirrel cage bars, breaks in squirrel cage end ring segments, combined static and dynamic eccentricity, clutch wobbling and vibration of bearings. The effect of these ailments is first investigated through simulations accomplished with a specially developed and implemented squirrel cage induction machine poly-harmonic model, as the fundamental harmonic models are not capable of simultaneous accounting for eccentricities, slotting and actual winding configuration. Two case studies, based on preregistered currents of big industrial machines, confirm the frequencies of interharmonics predicted by theory and simulations. The case studies refer to broken bars and clutch wobbling. The case study analyses were accomplished with the system Sp4 developed for offline diagnoses of induction machines.
Mathematical approach to THD optimisation in multilevel convertors.
Authors: A. Jan Iwaszkiewicz  , B. Jacek Perz  
Published: July 2017

The paper is related to the problem of generating the high qual-ity AC voltage waveforms using multilevel converters. This technique can be applied especially in the distributed power energy systems with renewable DC voltage sources like photo-voltaic farms and fuel cells. A novel approach to the synthesis of AC voltage waveforms, considering minimising of THD by use of analytical methods like Fourier transform is presented. The analysis of the obtained waveforms is presented as well as examples of chosen parameter optimisation. The meaning of the THD factor from the construction point of view is analysed and a new bandwidth factor THDB, containing more information about the frequency range of harmonic components is proposed in the paper.