bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous use of sodium nitrate and urea as nitrogen sources improves biomass composition of Arthrospira platensis cultivated in a tubular photobioreactor
Authors: Morocho‐Jácome Ana Lucía , Sato Sunao , de Lara Capurro Guimarães Laís , Knysak Camargo de Jesus Camila , Monteiro de Carvalho João Carlos 
Published: December 2015

Arthrospira platensis is widely cultivated in open ponds for industrial purposes. However, high‐protein A. platensis biomass produced in photobioreactors (PBRs) is recommended for pharmaceutical and cosmetic formulations. A. platensis was cultivated in a 3.5 L tubular airlift PBR using both sodium nitrate and urea as nitrogen sources. Sodium nitrate was added from the start of the cultivation using a batch process. Urea was supplied daily at exponentially increasing feeding rate using a fed‐batch process. The simultaneous optimization of the independent variables, namely, total quantity of sodium nitrate (mT1) and total quantity of urea (mT2), led to an optimal condition of mT1 = 15.0 mmol/L and mT2 = 7.5 mmol/L. Maximum biomass concentration (5183 ± 94 mg/L) corresponding to the highest biomass productivity (683 ± 13 mg/L/day) was obtained under such condition. The addition protocol of both nitrogen sources resulted in high productivities of protein (6.2 ± 0.4 mg/L/day) as well as chlorophyll‐a (372.2 ± 7.7 mg/L/day). Such innovative process could be applied in the large‐scale production of A. platensis using tubular PBR for novel applications.
Dopaminergic system and dream recall: An MRI study in Parkinson's disease patients
Authors: De Gennaro Luigi , Lanteri Olimpia , Piras Fabrizio , Scarpelli Serena , Assogna Francesca , Ferrara Michele , Caltagirone Carlo , Spalletta Gianfranco 
Published: December 2015

AbstractWe investigated the role of the dopamine system [i.e., subcortical‐medial prefrontal cortex (mPFC) network] in dreaming, by studying patients with Parkinson's Disease (PD) as a model of altered dopaminergic transmission. Subcortical volumes and cortical thickness were extracted by 3T‐MR images of 27 PD patients and 27 age‐matched controls, who were asked to fill out a dream diary upon morning awakening for one week. PD patients do not substantially differ from healthy controls with respect to the sleep, dream, and neuroanatomical measures. Multivariate correlational analyses in PD patients show that dopamine agonist dosage is associated to qualitatively impoverished dreams, as expressed by lower bizarreness and lower emotional load values. Visual vividness (VV) of their dream reports positively correlates with volumes of both the amygdalae and with thickness of the left mPFC. Emotional load also positively correlates with hippocampal volume. Beside the replication of our previous finding on the role of subcortical nuclei in dreaming experience of healthy subjects, this represents the first evidence of a specific role of the amygdala‐mPFC dopaminergic network system in dream recall. The association in PD patients between higher dopamine agonist dosages and impoverished dream reports, however, and the significant correlations between VV and mesolimbic regions, however, provide an empirical support to the hypothesis that a dopamine network plays a key role in dream generation. The causal relation is however precluded by the intrinsic limitation of assuming the dopamine agonist dosage as a measure of the hypodopaminergic state in PD. Hum Brain Mapp 37:1136–1147, 2016. © 2015 Wiley Periodicals, Inc.
Major depressive disorder: Findings of reduced homotopic connectivity and investigation of underlying structural mechanisms
Authors: Hermesdorf Marco , Sundermann Benedikt , Feder Stephan , Schwindt Wolfram , Minnerup Jens , Arolt Volker , Berger Klaus , Pfleiderer Bettina , Wersching Heike 
Published: December 2015

AbstractDepression has been associated with various alterations in magnetic resonance imaging (MRI) derived resting‐state functional connectivity. Recently, homotopic connectivity, defined as functional connectivity between homotopic regions across hemispheres, has been reported to be reduced in patients with major depressive disorder (MDD). However, little is known about structural factors underlying alterations of homotopic connectivity, which would contribute to the understanding of the altered neurophysiological architecture in patients with MDD. We compared 368 patients with MDD and 461 never‐depressed controls regarding voxel‐mirrored homotopic connectivity (VMHC) and potential underlying mechanisms such as the structural connectivity of the corpus callosum, measured by DTI‐derived fractional anisotropy (FA), and left–right symmetries in homotopic gray matter volumes. Compared to controls, patients with MDD exhibited reduced VMHC in the cuneus, putamen, superior temporal gyrus, insula, and precuneus. Within these regions, no differences in left–right symmetries in homotopic gray matter volumes were evident across cohorts. FA of the corpus callosum correlated with VMHC in the entire sample. However, patients with MDD and controls did not differ with regard to callosal FA. The findings indicate that MDD is associated with a loss of interhemispheric synchrony in regions known to be implicated in self‐referential and reward processing. They also suggest that additional mechanisms are implicated in altered homotopic connectivity of patients with MDD, other than direct callosal fiber pathways or asymmetries in homotopic gray matter volumes. Hum Brain Mapp 37:1209–1217, 2016. © 2015 Wiley Periodicals, Inc.
Three‐dimensional endoscopy in transnasal transsphenoidal approach to clival chordomas
Authors: Garzaro Massimiliano , Zenga Francesco , Raimondo Luca , Pacca Paolo , Pennacchietti Valentina , Riva Giuseppe , Ducati Alessandro , Pecorari Giancarlo 
Published: December 2015

AbstractBackgroundThe purpose of this prospective, observational study was to evaluate the management of skull base chordomas surgically resected via a 3D‐endoscopic transnasal approach.MethodsThirteen consecutive patients were observed and only 9 were surgically treated using a 3D‐endoscopic transnasal approach assisted by a novel 3D visualization system.ResultsNine consecutive male patients (mean age, 57.4 years) underwent exclusive 3D‐endoscopic transnasal transsphenoidal resection of clival chordomas; gross total resection was achieved in 66.6% of cases (6 of 9 patients), near‐total resection in 11.2% (1 of 9 patients), and partial resection in 22.2% (2 of 9 patients). The complications observed were 2 cases of postoperative cerebrospinal fluid (CSF) leaks and 1 case of temporary VI cranial nerve palsy.ConclusionNo discomfort was recorded; when a dura opening was required, 3D vision allowed an accurate intradural sharp dissection and a precise repair of the skull base. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1814–E1819, 2016
Primary inverted papilloma of the middle ear with intracranial invasion
Authors: Coca‐Pelaz Andrés , Gómez–Martínez Justo , Vivanco–Allende Blanca , Hermsen Mario , Llorente Jose Luis 
Published: December 2015

AbstractBackgroundPrimary inverted papillomas of the middle ear are extremely rare tumors, with only few cases published in the literature. They have a characteristic epithelium surface inversion to the inside of the stroma. Inverted papillomas are benign lesions but have a high propensity of recurrence, local aggressiveness, and association with malignancy.MethodsWe present a patient with an inverted papilloma originating in the middle ear producing chronic otorrhea and facial nerve palsy treated with a subtotal petrosectomy.ResultsDuring the follow‐up, the patient developed an intracranial invasion of the tumor causing his death.ConclusionPrimary inverted papillomas of the middle ear can have an extremely aggressive behavior despite their benign characteristics; therefore, an aggressive treatment must be performed in order to minimize the possibility of recurrence. © 2015 Wiley Periodicals, Inc. Head Neck 38: E105–E107, 2016
Near infrared fluorescent imaging after intravenous injection of indocyanine green during neck dissection in patients with head and neck cancer: A feasibility study
Authors: Digonnet Antoine , van Kerckhove Sophie , Moreau Michel , Willemse Esther , Quiriny Marie , Ahmed Bissan , de Saint Aubain Nicolas , Andry Guy , Bourgeois Pierre 
Published: December 2015

AbstractBackgroundIndocyanine green (ICG) has not been studied during therapeutic lymph node dissections after intravenous injection. The purpose of this study was to explore the distribution of ICG in lymphatic nodes during neck dissection.MethodsEleven patients requiring neck dissection with or without resection of the primary lesion were included. ICG was intravenously injected at induction time of anesthesia. Imaging was performed before and after surgical resection. Fluorescence was measured in arbitrary units (AUs) in the pathology department. Mixed linear model and generalized estimating equations (GEEs) were used.ResultsMean fluorescence of invaded nodes was 22.6 AUs (SD = 24.9) and 3.9 AUs (SD = 8.1) in negative nodes (p = .016). After adjustment for the size of the node, the risk of invasion when fluorescence was observed was 12.2 (95% confidence interval [CI] = 5.3–28.2; p < .0001).ConclusionThis study demonstrates the feasibility of ICG to bring a contrast during surgery between healthy and invaded nodes after i.v. injection. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1833–E1837, 2016
Features and prognostic utility of biopsy in oral squamous cell carcinoma
Authors: Dhanda Jagtar , Uppal Nugdeep , Chowlia Harpreet , Opie Neil , Al‐Qamachi Laith , Shelat Devesh , Aslam Adil , Yuffa Arie , Martin Timothy , Risk Janet , Triantafyllou Asterios , Shaw Richard , Parmar Satyesh , Mehanna Hisham 
Published: December 2015

AbstractBackgroundTraditional approaches in oral squamous cell carcinoma (OSCC) management utilize biopsy tissue for diagnostic purposes only. Adverse prognostic features, such as the tumor depth, are usually determined from final resection specimens, but are seldom studied in biopsy tissue.MethodsA preliminary study of 139 consecutive biopsies compared biopsy size with T classification, tumor site, and operator grade, and biopsy tumor depth with the true tumor depth.ResultsThis study demonstrated that biopsy size is independent of T classification (p = .44), subsite (p = .86), and operator grade (p = .10). The biopsy tumor depth significantly underrepresented true tumor depth (2.5 mm, 95% confidence interval [CI] = 2.4–2.9 vs 8.2 mm, 95% CI = 6.5–9.9; p < .001), confirming the limited prognostic utility of biopsies in OSCC.ConclusionA future clinical trial will compare the routine biopsy technique with standardized deeper biopsy techniques using punch biopsy to sample invasive fronts and investigate opportunities for up‐front staging using a combination of histological features and epithelial and stromal molecular biomarkers in OSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1857–E1862, 2016
Evaluation of the donor cell contribution in rhBMP‐2 mediated bone formation with chitosan thermogels using fluorescent protein reporter mice
Authors: Gohil Shalini V. , Kuo Chia‐Ling , Adams Douglas J. , Maye Peter , Rowe David W. , Nair Lakshmi S. 
Published: December 2015

AbstractOur current understanding regarding the contribution of donor cells in growth factor and cell based tissue regeneration strategies is limited. The present study attempts to utilize fluorescent protein reporter mice [Col3.6Topaz (enhanced yellow fluorescent protein, EYFP) as host and Col3.6Cyan (enhanced cyan fluorescent protein, ECFP) as donor] to determine donor cell contribution in bone regeneration using a bilateral calvarial defect model. Thermogelling chitosan hydrogels (Chi‐AHP) were used as bone marrow stromal cell (BMSC) delivery vehicle in the presence and absence of recombinant human bone morphogenetic protein‐2 (rhBMP‐2). Co‐delivery of rhBMP‐2 and donor BMSCs led to a significant increase in bone formation indicating the potential of using the combination approach for improved regeneration. On a cellular level, presence of rhBMP‐2 resulted in an increased host cell derived osteoblast infiltration at 8 weeks. However, the new mineralized tissue presented two distinct morphological features based on its cellular origin. Regenerated tissue associated with ECFP positive donor cells showed a woven bone‐like structure with diffuse alizarin complexone (AC) label and minimal tartrate resistant acid phosphatase (TRAP) activity, indicating the presence of immature early osteoblast cells depositing mineralized tissue without progressing to a mature lamellar bone. Host derived bone showed sharp mineralization line (AC), strong alkaline phosphatase (ALP) and TRAP activity, indicating the presence of actively mineralizing and remodeling, mature lamellar bone matrix. The study demonstrated the remarkable potential of transgenic reporters to improve our understanding of donor cell contribution during bone formation. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 928–941, 2016.
Regenerative endodontics—Creating new horizons
Authors: Dhillon Harnoor , Kaushik Mamta , Sharma Roshni 
Published: December 2015

AbstractTrauma to the dental pulp, physical or microbiologic, can lead to inflammation of the pulp followed by necrosis. The current treatment modality for such cases is non‐surgical root canal treatment. The damaged tissue is extirpated and the root canal system prepared. It is then obturated with an inert material such a gutta percha. In spite of advances in techniques and materials, 10%–15% of the cases may end in failure of treatment. Regenerative endodontics combines principles of endodontics, cell biology, and tissue engineering to provide an ideal treatment for inflamed and necrotic pulp. It utilizes mesenchymal stem cells, growth factors, and organ tissue culture to provide treatment. Potential treatment modalities include induction of blood clot for pulp revascularization, scaffold aided regeneration, and pulp implantation. Although in its infancy, successful treatment of damaged pulp tissue has been performed using principles of regenerative endodontics. This field is dynamic and exciting with the ability to shape the future of endodontics. This article highlights the fundamental concepts, protocol for treatment, and possible avenues for research in regenerative endodontics. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 676–685, 2016.
Esophageal reconstruction by colon interposition after esophagectomy for cancer analysis of current indications, operative outcomes, and long‐term survival
Authors: Reslinger Vincent , Tranchart Hadrien , D'Annunzio Elsa , Poghosyan Tigran , Quero Laurent , Munoz‐Bongrand Nicolas , Corte Helene , Sarfati Emile , Cattan Pierre , Chirica Mircea 
Published: December 2015

IntroductionColon interposition is an alternative solution for esophageal reconstruction if the stomach cannot be used. The study reviews current indications and results of coloplasty for cancer.MethodsPatients who underwent colon interposition for gastro‐esophageal malignancy were included. Primary coloplasty was defined as upfront colon interposition. Salvage coloplasty was defined as colon interposition after primary reconstruction failure. Mortality, morbidity, function, and survival were evaluated.ResultsWe included 28 patients (24 men, median age 61 years). Ten (36%) patients underwent primary coloplasty due to previous gastrectomy (n = 5), conduit gastric cancer (n = 2), extensive gastroesophageal involvement (n = 2), and gastric cancer recurrence (n = 1). Salvage coloplasty was performed in 18 (64%) patients for postoperative graft necrosis (n = 5) and intractable strictures (n = 3). Operative mortality, morbidity, and graft necrosis rates were 14% (4/28), 86% (24/28), and 14% (4/28), respectively; there were no significant differences between primary and salvage coloplasty. Survival rates at 1‐, 3‐, and 5 years were 81%, 51%, and 38%, respectively. Survival was decreased after primary coloplasty when compared to salvage coloplasty (P = 0.03). Nine patients experienced tumor recurrence (primary: n = 6, salvage: n = 3) after coloplasty and eight of them died.ConclusionColon interposition after esophagectomy is a useful but morbid endeavor. Colon interposition as salvage therapy is associated with improved survival compared to its use as primary esophageal replacement, and colon interposition in the latter cohort should be used with caution due to poor cancer‐specific survival in this patient population. J. Surg. Oncol. 2016;113:159–164. © 2015 Wiley Periodicals, Inc.
Associations Between Cardiovascular Events and Nonergot Dopamine Agonists in Parkinson's Disease
Authors: Crispo James A.G. , Willis Allison W. , Thibault Dylan P. , Fortin Yannick , Emons Matthew , Bjerre Lise M. , Kohen Dafna E. , Perez‐Lloret Santiago , Mattison Donald , Krewski Daniel 
Published: December 2015

AbstractBackgroundKnowledge of possible cardiovascular risks from Parkinson's disease (PD) medications is critical to informing safe and effective treatment decisions. The objective of our study was to determine whether PD patients treated with nonergot dopamine agonists (DAs) are at increased risk of adverse cardiovascular or cerebrovascular outcomes, relative to PD patients receiving other treatments.MethodsMatched case‐control studies were conducted within a cohort of 14,122 inpatients receiving treatment for PD who were identified in the Cerner Health Facts database. Primary outcomes were associations between nonergot DA use and diagnosis of adverse cardiovascular events (acute myocardial infarction, heart failure [HF], hypotension, and valvulopathy). Secondary outcomes included associations between nonergot DA use and diagnosis of adverse cerebrovascular events (cerebrovascular accident and ischemic stroke) and odds of significant exposure‐outcome relationships by patient factors.ResultsHF was the only adverse event that demonstrated a significant association with nonergot DA use. Individuals treated with pramipexole were more likely to be diagnosed with HF, relative to no use (adjusted odds ratio [AOR]: 1.28; 95% confidence interval [CI]: 1.07–1.53). The association between pramipexole and HF was greater among individuals treated with pramipexole monotherapy (relative to levodopa monotherapy) (AOR, 1.50; 95% CI: 1.09–2.06). Compared to nonusers, men and older individuals treated with pramipexole were more likely to be diagnosed with HF.ConclusionsResults from our study suggest an association between pramipexole use and HF. Findings warrant replication; however, individuals with PD and independent risk factors for, or a history of, HF may benefit from limited use of this drug.
A compact four elements UWB MIMO antenna with on‐demand WLAN rejection
Authors: Khan Saeed M. , Iftikhar Adnan , Asif Sajid M. , Capobianco Antonio‐Daniele , Braaten Benjamin D. 
Published: December 2015

ABSTRACTThis article presents a four elements frequency reconfigurable ultrawideband (UWB) multiple‐input‐multiple‐output (MIMO) design, capable of rejecting on‐demand WLAN band ranging from 4.8 to 6.2 GHz. The proposed design consists of two U‐shaped monopole UWB radiators and two circular slotted‐monopole radiators. These monopole radiators are placed orthogonally with respect to each other to exploit polarization diversity, whereas the PIN diodes are used to connect the band‐stop design with the ground plane to introduce the on‐demand band rejection feature. An isolation of better than 17 dB between the four UWB‐MIMO elements is achieved in the 2.7–12 GHz frequency range for the both PIN diodes biased and unbiased states. The simulations and measurements results showed good agreement over the band of interest. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:270–276, 2016
Wideband planar monopole antennas for GPS/WLAN/WiMAX/UWB and X‐band applications
Authors: Bozdag Goksenin , Kustepeli Alp 
Published: December 2015

ABSTRACTIn this article, two printed planar monopole antennas (PPMA) are presented. In the design of the first PPMA, the structure is divided into sections and they are optimized in the sense of bottom to up strategy. Tapered transitions and inset feed are employed to increase the bandwidth. The antenna operates between 2.37 GHz and 12 GHz with VSWR<2 and an average peak realized gain of 4.95 dB. Therefore, it is suitable for WLAN, WiMAX, UWB, and X‐Band applications. The second PPMA is designed by implementing slots on the previous one to include GPS. The resulting antenna operates in the 1.38–1.60 GHz and 2.33–13.74 GHz bands with VSWR<2. As a result, it also includes GPS in addition to the previous bands. The peak realized gain in GPS is 0.47 dB at 1.575 GHz and the average peak realized gain is 4.41 dB for the 2.33–13.74 GHz band. The group delay performances of the proposed PPMAs are also examined and the maximum group delay deviations of the first and the second PPMAs are observed as 1 ns and 1.33 ns, respectively. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:257–261, 2016
A selective robust SRR providing notched band in conical monopole UWB antenna
Authors: Jang Eun Seok , Kim Kyungsoo , Park Jeung Keun , Kim Che‐Young 
Published: December 2015

ABSTRACTThis study presents a systematic design method for a conical‐type monopole antenna exclusively for use in an ultrawide band (UWB). The suggested antenna adopts a structure called the split ring resonator (SSR), in which one resonant element can be easily attached and detached. It is possible to adjust the size of the SSR and the gaps; this SSR, operating at the relevant frequency, can be attached to and removed from the antenna, making it easier to adjust the rejection band. The suggested antenna covers a UWB ranging from 3.1 to 10.6 GHz. Through a simulation, we found that the rejection characteristics of the suggested antenna can be changed among WLAN (5.75 GHz), C‐band (4 GHz), WiMAX (3.5 GHz), and X‐band (7.8 GHz), and that the measurements in the WLAN and WiMAX bands show rejection characteristics. Additionally, the suggested antenna has a peak gain of over 3 dBi in the operation band and shows omnidirectional radiation patterns. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:332–337, 2016
Dual‐band, low‐profile, vertically polarized annular ring slot antenna embedded in a small metallic UAV
Authors: Sun Ling , Sun Baohua , Yuan Jiangpeng , Tang Wending 
Published: December 2015

ABSTRACTA dual‐band, low‐profile, vertically‐polarized annular ring slot antenna is presented. The antenna consists of an annular ring slot structure and a ring‐shaped structure. The ring‐shaped structure is attached on the back of the annular ring slot structure using two sets of conductive vias to avoid increasing the size of the proposed antenna. Dual‐band characteristic is realized by adjusting the radius of the annular ring slot structure and the ring‐shaped structure. Analysis of the dual‐band characteristic of the proposed antenna is discussed. The proposed antenna is vertically polarized and provides a monopole‐like radiation pattern on both the frequency bands. The ground size of the proposed antenna is the same size as the antenna radius. The ground plane is relatively small comparing with most of the other vertically polarized patch antennas. The edge of the proposed antenna is shorted by a set of conductive vias. The proposed antenna is insensitive to the surrounding environment and thus can be embedded in a metallic unmanned aerial vehicles (UAV). A prototype with a height of 3.048 mm (0.03λ) and radius of 55 mm (0.45λ) is designed, fabricated, and measured. The proposed antenna works at 2.38 and 2.58 GHz. In addition, the proposed antenna embedded in a metallic UAV is simulated. The results show that the metallic UAV has small effect on the performance of the antenna. The proposed antenna is suitable for the operations of being controlled by a ground control station (GCS) and transmitting data to the GCS simultaneously for a small UAV. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:323–328, 2016