bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional vulnerability in Alzheimer's disease: The role of cell‐autonomous and transneuronal processes
Authors: Acosta Diana , Powell Fontasha , Zhao Yize , Raj Ashish 
Published: January 2018

AbstractIntroductionThe stereotypical progression of Alzheimer's disease (AD) pathology is not fully understood. The selective impact of AD on distinct regions has led the field to question if innate vulnerability exists. This study aims to determine if the causative factors of regional vulnerability are dependent on cell‐autonomous or transneuronal (non–cell autonomous) processes.MethodsUsing mathematical and statistical models, we analyzed the contribution of cell‐autonomous and non–cell autonomous factors to predictive linear models of AD pathology.ResultsResults indicate gene expression as a weak contributor to predictive linear models of AD. Instead, the network diffusion model acts as a strong predictor of observed AD atrophy and hypometabolism.DiscussionWe propose a convenient methodology for identifying genes and their role in determining AD topography, in comparison with network spread. Results reinforce the role of transneuronal network spread on disease progression and suggest that innate gene expression plays a secondary role in seeding and subsequent disease progression.
Avaliação funcional da reconstrução do ligamento patelofemoral medial em atletas
Authors: Garms Emerson , Carvalho Rogerio Teixeira de , Janovsky César , Nicolini Alexandre Pedro , Salviani Rafael Salmeron , Liggieri Andre Cicone 
Published: January 2018

Resumo
Objetivo Avaliar os resultados clínicos e funcionais da reconstrução anatômica do ligamento patelofemoral medial com tendões flexores em atletas.
Métodos Estudo tipo série de casos, prospectivo, que analisou a reconstrução do ligamento patelofemoral medial em 32 pacientes (34 joelhos). A avaliação funcional foi feita pelos escores Lysholm e Kujala nos períodos pré e pós-operatórios e os fatores de risco envolvidos foram avaliados.
Resultados Dos 32 pacientes analisados, todos obtiveram melhoria dos escores funcionais comparativamente ao período pré-operatório. Pacientes com menos de cinco episódios de luxação prévios obtiveram melhores resultados funcionais. O valor médio de Lysholm no pré-operatório foi de 62,8 e no pós-operatório de 94,3, quanto ao escore de Kujala a média pré-operatório foi de 63,0 e pós-operatória de 94,0.
Conclusão A reconstrução do ligamento patelofemoral medial com enxerto de tendão flexor do joelho em atletas propiciou melhoria dos escores clínicos e funcionais nos pacientes com instabilidade patelofemoral. A perfuração óssea da patela e o posicionamento do túnel femoral devem ocorrer de forma judiciosa.
The challenge of monitoring glaciers with extreme altitudinal range: mass-balance reconstruction for Kahiltna Glacier, Alaska
Authors: YOUNG JOANNA C. , ARENDT ANTHONY , HOCK REGINE , PETTIT ERIN 
Published: January 2018

ABSTRACTGlaciers spanning large altitudinal ranges often experience different climatic regimes with elevation, creating challenges in acquiring mass-balance and climate observations that represent the entire glacier. We use mixed methods to reconstruct the 1991–2014 mass balance of the Kahiltna Glacier in Alaska, a large (503 km2) glacier with one of the greatest elevation ranges globally (264–6108 m a.s.l.). We calibrate an enhanced temperature index model to glacier-wide mass balances from repeat laser altimetry and point observations, finding a mean net mass-balance rate of −0.74 mw.e. a−1( ± σ = 0.04, std dev. of the best-performing model simulations). Results are validated against mass changes from NASA's Gravity Recovery and Climate Experiment (GRACE) satellites, a novel approach at the individual glacier scale. Correlation is strong between the detrended model- and GRACE-derived mass change time series (R2 = 0.58 and p ≪ 0.001), and between summer (R2 = 0.69 and p = 0.003) and annual (R2 = 0.63 and p = 0.006) balances, lending greater confidence to our modeling results. We find poor correlation, however, between modeled glacier-wide balances and recent single-stake monitoring. Finally, we make recommendations for monitoring glaciers with extreme altitudinal ranges, including characterizing precipitation via snow radar profiling.
Levantine Joint-Stock Companies, Trans-Mediterranean Partnerships, and Nineteenth-Century Capitalist Development
Authors: Alff Kristen 
Published: January 2018

AbstractThe Levantine business community—the Sursuqs, Bustruses, Tuenis, Khuris, Debbases, Trads, Tabets, Naggiars, and Farahs—created large agricultural estates in the Levant and established company branches in Beirut, Alexandria, Haifa, London, Liverpool, Paris, and Marseille in the mid-nineteenth century. Against both culturalist and new institutional paradigms, I argue that the trajectories of the Levantine firms were much like those of their European counterparts; Dutch and English capitalism—what came to be recognized as modern forms of capitalism—developed out of long-distance trade and relied on forms of coerced and semi-coerced labor as well as other so-called “non-capitalist” or “precapitalist” elements. Beirut-based companies relied on tenant contracts, sharecropping, and other forms of labor control rooted in the Ottoman social formation. Drawing upon the unexplored private papers of these business families in Beirut and a diverse collection of documents from Istanbul, Beirut, Jerusalem, London, Liverpool, and Marseille in Arabic, German, Ottoman Turkish, and French, this paper examines the parallels and the links between the business practices of the Levantine joint-stock companies and their European partners. It contends that the development of nineteenth-century capitalism relied on several different institutions and relations of production formulated and articulated on both sides of the Mediterranean and in the competition between them. Only after World War I, because of settler-colonialism, the settlement of nomads, and large-scale European capital investment backed by imperial power, did Levantine capital accumulation begin to take a form that was subordinate to Europe.
Politics and the Work of the Dead in Modern India
Authors: Moffat Chris 
Published: January 2018

AbstractThis article provides a framework for understanding the continuing political potential of the anticolonial dead in twenty-first-century India. It demonstrates how scholars might move beyond histories of reception to interrogate the force of inheritance in contemporary political life. Rather than the willful conjuring of the dead by the living, for a politics in the present, it considers the more provocative possibility that the dead might themselves conjure politics—calling the living to account, inciting them to action. To explicate the prospects for such an approach, the article traces the contested afterlives of martyred Indian revolutionary Bhagat Singh (1907–1931), comparing three divergent political projects in which this iconic anticolonial hero is greeted as interlocutor in a struggle caught “halfway.” It is this temporal experience of “unfinished business”—of a revolution left incomplete, a freedom not yet perfected—that conditions Bhagat Singh's appearance as a contemporary in the political disputes of the present, whether they are on the Hindu nationalist right, the Maoist student left, or amidst the smoldering remains of Khalistani separatism in twenty-first-century Punjab. Exploring these three variant instances in which living communities affirm Bhagat Singh's stake in the struggles of the present, the article provides insight into the long-term legacies of revolutionary violence in India and the relationship between politics and the public life of history in the postcolonial world more generally.
Orthodox Internationalism: State and Church in Modern Russia and Ethiopia
Authors: Rupprecht Tobias 
Published: January 2018

AbstractRussia and Ethiopia, both multiethnic empires with traditionally orthodox Christian ruling elites, from the nineteenth century developed a special relationship that outlived changing geopolitical and ideological constellations. Russians were fascinated with what they saw as exotic brothers in the faith, and Ethiopians took advantage of Russian help and were inspired by various features of modern Russian statecraft. This article examines contacts and interactions between the elites of these two distant countries, and the changing relations between authoritarian states and Orthodox churches from the age of European imperialism to the end of the Cold War. It argues that religio-ethnic identities and institutionalized religion have grounded tenacious visions of global political order. Orthodoxy was the spiritual basis of an early anti-Western type of globalization, and was subsequently coopted by states with radically secular ideologies as an effective means of mass mobilization and control.
Publisher Correction: Observation of transverse spin Nernst magnetoresistance induced by thermal spin current in ferromagnet/non-magnet bilayers
Authors: Kim Dong-Jun , Jeon Chul-Yeon , Choi Jong-Guk , Wook Lee Jae , Surabhi Srivathsava , Jeong Jong-Ryul , Lee Kyung-Jin , Park Byong-Guk 
Published: January 2018

The original version of this Article contained an error in ref. 27, which was incorrectly given with the wrong journal name as:Meyer, S. et al. Observation of the spin Nernst effect. Nat. Phys. 16, 977–981 (2017).The correct form of ref. 27 is:Meyer, S. et al. Observation of the spin Nernst effect. Nat. Mater. 16, 977–981 (2017).This has now been corrected in the PDF and HTML versions of the Article.
The use of accelerometry as a tool to measure disturbed nocturnal sleep in Parkinson’s disease
Authors: McGregor Sarah , Churchward Philip , Soja Katarzyna , O’Driscoll Denise , Braybrook Michelle , Khodakarami Hamid , Evans Andrew , Farzanehfar Parisa , Hamilton Garun , Horne Malcolm 
Published: January 2018

AbstractSleep disturbances are common in Parkinson’s disease (PD). We used the Parkinson’s KinetiGraph (PKG), an objective movement recording system for PD to assess night time sleep in 155 people aged over 60 and without PD (controls), 72 people with PD (PwP) and 46 subjects undergoing a Polysomnogram (PSG: 36 with sleep disorder and 10 with normal sleep). The PKG system uses a wrist worn logger to capture acceleration and derive a bradykinesia score (BKS) every 2 min over 6 days. The BKS ranges from 0–160 with higher scores associated with lesser mobility. Previously we showed that BKS > 80 were associated with day time sleep and used this to produce scores for night time sleep: Efficiency (Percent time with BKS > 80), Fragmentation (Average duration of runs of BKS > 80) and Sleep Quality (BKS > 111 as a representation of atonia). There was a fair association with BKS score and sleep level as judged by PSG. Using these PKG scores, it was possible to distinguish between normal and abnormal PSG studies with good Selectivity (86%) and Sensitivity (80%). The PKG’s sleep scores were significantly different in PD and Controls and correlated with a subject’s self-assessment (PDSS 2) of the quality, wakefulness and restlessness. Using both the PDSS 2 and the PKG, it was apparent that sleep disturbances were apparent early in disease in many PD subjects and that subjects with poor night time sleep were more likely to have day time sleepiness. This system shows promise as a quantitative score for assessing sleep in Parkinson’s disease.
Distinction of Plasmodium ovale wallikeri and Plasmodium ovale curtisi using quantitative Polymerase Chain Reaction with High Resolution Melting revelation
Authors: Joste V. , Kamaliddin C. , Kendjo E. , Hubert V. , Argy N. , Houzé S. 
Published: January 2018

AbstractPlasmodium ovale curtisi (Poc) and Plasmodium ovale wallikeri (Pow) have been described as two distinct species, only distinguishable by molecular methods such as PCR. Because of no well-defined endemic area and a variable clinical presentation as higher thrombocytopenia and nausea associated with Pow infection and asymptomatic forms of the pathology with Poc infection, rapid and specific identification of Plasmodium ovale curtisi and Plasmodium ovale wallikeri are needed. The aim of the study was to evaluate a new quantitative real-time PCR coupled with high resolution melting revelation (qPCR-HRM) for identification of both species. Results were compared with a nested-PCR, considered as a gold standard for Pow and Poc distinction. 356 samples including all human Plasmodium species at various parasitaemia were tested. The qPCR-HRM assay allowed Poc and Pow discrimination in 66 samples tested with a limit of detection evaluated at 1 parasite/µL. All these results were concordant with nested-PCR. Cross-reaction was absent with others blood parasites. The qPCR-HRM is a rapid and convenient technique to Poc and Pow distinction.
Specific inhibition of acetylcholinesterase as an approach to decrease muscarinic side effects during myasthenia gravis treatment
Authors: Petrov Konstantin A. , Kharlamova Alexandra D. , Lenina Oksana A. , Nurtdinov Ayrat R. , Sitdykova Marina E. , Ilyin Victor I. , Zueva Irina V. , Nikolsky Evgeny E. 
Published: January 2018

AbstractNon-selective inhibitors of cholinesterases (ChEs) are clinically used for treatment of myasthenia gravis (MG). While being generally safe, they cause numerous adverse effects including induction of hyperactivity of urinary bladder and intestines affecting quality of patients life. In this study we have compared two ChEs inhibitors, a newly synthesized compound C547 and clinically used pyridostigmine bromide, by their efficiency to reduce muscle weakness symptoms and ability to activate contractions of urinary bladder in a rat model of autoimmune MG. We found that at dose effectively reducing MG symptoms, C547 did not affect activity of rat urinary bladder. In contrast, at equipotent dose, pyridostigmine caused a significant increase in tonus and force of spontaneous contractions of bladder wall. We also found that this profile of ChEs inhibitors translates into the preparation of human urinary bladder. The difference in action observed for C547 and pyridostigmine we attribute to a high level of pharmacological selectivity of C547 in inhibiting acetylcholinesterase as compared to butyrylcholinesterase. These results raise reasonable hope that selective acetylcholinesterase inhibitors should show efficacy in treating MG in human patients with a significant reduction in adverse effects related to hyperactivation of smooth muscles.
Biopsy Needle Integrated with Electrical Impedance Sensing Microelectrode Array towards Real-time Needle Guidance and Tissue Discrimination
Authors: Park Jaeho , Choi Won-Mook , Kim Kyuyoung , Jeong Won-Il , Seo Joon-Beom , Park Inkyu 
Published: January 2018

AbstractA biopsy needle with electrical impedance sensor array based on stainless steel microelectrodes (EIS needle) was developed for real-time four electrode measurement and multi-spot sensing of tissues during the biopsy process. The sensor performance was characterized by using saline solutions with various concentrations, which proved accurate, stable and reliable electrical impedance measurement. The capability of impedance-based tissue sensing was verified by the conductivity measurement of agarose hydrogel based phantom mimicking cancer tissue. Furthermore, multi-spot impedance sensing during needle insertion was demonstrated using porcine meat with muscle and fat layers, which exhibited a clear discrimination between different types of tissues. Also, the electrical impedance difference between normal and fatty livers of mouse model was measured by the EIS needle. We could successfully demonstrate that the EIS needle can provide localized and accurate characterization of biological tissues at the needle tip.
A new, large-bodied omnivorous bat (Noctilionoidea: Mystacinidae) reveals lost morphological and ecological diversity since the Miocene in New Zealand
Authors: Hand Suzanne J. , Beck Robin M. D. , Archer Michael , Simmons Nancy B. , Gunnell Gregg F. , Scofield R. Paul , Tennyson Alan J. D. , De Pietri Vanesa L. , Salisbury Steven W. , Worthy Trevor H. 
Published: January 2018

AbstractA new genus and species of fossil bat is described from New Zealand’s only pre-Pleistocene Cenozoic terrestrial fauna, the early Miocene St Bathans Fauna of Central Otago, South Island. Bayesian total evidence phylogenetic analysis places this new Southern Hemisphere taxon among the burrowing bats (mystacinids) of New Zealand and Australia, although its lower dentition also resembles Africa’s endemic sucker-footed bats (myzopodids). As the first new bat genus to be added to New Zealand’s fauna in more than 150 years, it provides new insight into the original diversity of chiropterans in Australasia. It also underscores the significant decline in morphological diversity that has taken place in the highly distinctive, semi-terrestrial bat family Mystacinidae since the Miocene. This bat was relatively large, with an estimated body mass of ~40 g, and its dentition suggests it had an omnivorous diet. Its striking dental autapomorphies, including development of a large hypocone, signal a shift of diet compared with other mystacinids, and may provide evidence of an adaptive radiation in feeding strategy in this group of noctilionoid bats.
Aster leafhopper survival and reproduction, and Aster yellows transmission under static and fluctuating temperatures, using ddPCR for phytoplasma quantification
Authors: Bahar Md H. , Wist Tyler J. , Bekkaoui Diana R. , Hegedus Dwayne D. , Olivier Chrystel Y. 
Published: January 2018

AbstractAster yellows (AY) is an important disease of Brassica crops and is caused by Candidatus Phytoplasma asteris and transmitted by the insect vector, Aster leafhopper (Macrosteles quadrilineatus). Phytoplasma-infected Aster leafhoppers were incubated at various constant and fluctuating temperatures ranging from 0 to 35 °C with the reproductive host plant barley (Hordium vulgare). At 0 °C, leafhopper adults survived for 18 days, but failed to reproduce, whereas at 35 °C insects died within 18 days, but successfully reproduced before dying. Temperature fluctuation increased thermal tolerance in leafhoppers at 25 °C and increased fecundity of leafhoppers at 5 and 20 °C. Leafhopper adults successfully infected and produced AY-symptoms in canola plants after incubating for 18 days at 0–20 °C on barley, indicating that AY-phytoplasma maintains its virulence in this temperature range. The presence and number of AY-phytoplasma in insects and plants were confirmed by droplet digital PCR (ddPCR) quantification. The number of phytoplasma in leafhoppers increased over time, but did not differ among temperatures. The temperatures associated with a typical crop growing season on the Canadian Prairies will not limit the spread of AY disease by their predominant insect vector. Also, ddPCR quantification is a useful tool for early detection and accurate quantification of phytoplasma in plants and insects.
Neural measures of the role of affective prosody in empathy for pain
Authors: Meconi Federica , Doro Mattia , Schiano Lomoriello Arianna , Mastrella Giulia , Sessa Paola 
Published: January 2018

AbstractEmotional communication often needs the integration of affective prosodic and semantic components from speech and the speaker’s facial expression. Affective prosody may have a special role by virtue of its dual-nature; pre-verbal on one side and accompanying semantic content on the other. This consideration led us to hypothesize that it could act transversely, encompassing a wide temporal window involving the processing of facial expressions and semantic content expressed by the speaker. This would allow powerful communication in contexts of potential urgency such as witnessing the speaker’s physical pain. Seventeen participants were shown with faces preceded by verbal reports of pain. Facial expressions, intelligibility of the semantic content of the report (i.e., participants’ mother tongue vs. fictional language) and the affective prosody of the report (neutral vs. painful) were manipulated. We monitored event-related potentials (ERPs) time-locked to the onset of the faces as a function of semantic content intelligibility and affective prosody of the verbal reports. We found that affective prosody may interact with facial expressions and semantic content in two successive temporal windows, supporting its role as a transverse communication cue.
Random telegraph noise from resonant tunnelling at low temperatures
Authors: Li Zuo , Sotto Moïse , Liu Fayong , Husain Muhammad Khaled , Yoshimoto Hiroyuki , Sasago Yoshitaka , Hisamoto Digh , Tomita Isao , Tsuchiya Yoshishige , Saito Shinichi 
Published: January 2018

AbstractThe Random Telegraph Noise (RTN) in an advanced Metal-Oxide-Semiconductor Field-Effect Transistor (MOSFET) is considered to be triggered by just one electron or one hole, and its importance is recognised upon the aggressive scaling. However, the detailed nature of the charge trap remains to be investigated due to the difficulty to find out the exact device, which shows the RTN feature over statistical variations. Here, we show the RTN can be observed from virtually all devices at low temperatures, and provide a methodology to enable a systematic way to identify the bias conditions to observe the RTN. We found that the RTN was observed at the verge of the Coulomb blockade in the stability diagram of a parasitic Single-Hole-Transistor (SHT), and we have successfully identified the locations of the charge traps by measuring the bias dependence of the RTN.
Uncoupled mitochondria quickly shorten along their long axis to form indented spheroids, instead of rings, in a fission-independent manner
Authors: Miyazono Yoshihiro , Hirashima Shingo , Ishihara Naotada , Kusukawa Jingo , Nakamura Kei-ichiro , Ohta Keisuke 
Published: January 2018

AbstractLoss of mitochondrial membrane potential (ΔΨm) triggers dramatic structural changes in mitochondria from a tubular to globular shape, referred to as mitochondrial fragmentation; the resulting globular mitochondria are called swelled or ring/doughnut mitochondria. We evaluated the early period of structural changes during the ΔΨm loss-induced transformation after carbonyl cyanide m-chlorophenyl hydrazine (CCCP) administration using a newly developed correlative microscopic method combined with fluorescence microscopic live imaging and volume electron microscopy. We found that most mitochondria changed from a tubular shape to a globular shape without fusion or fission and typically showed ring shapes within 10 min after CCCP exposure. In contrast, most ring mitochondria did not have a true through hole; rather, they had various indents, and 47% showed stomatocyte shapes with vase-shaped cavities, which is the most stable physical structure without any structural support if the long tubular shape shortens into a sphere. Our results suggested that loss of ΔΨm triggered collapse of mitochondrial structural support mechanisms.