bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overcoming functional impairment in postpartum depressed or anxious women: a pilot trial of desvenlafaxine with flexible dosing
Authors: Misri Shaila , Swift Elena , Abizadeh Jasmin , Shankar Radhika 
Published: June 2016

Objectives: Antidepressants are the first line treatment for moderate to severe major depressive disorder (MDD) in perinatal and general populations. However, there appears to be paucity of evidence around antidepressant use in women with postpartum depression or anxiety. Selection of an appropriate antidepressant is crucial in promoting efficacy, optimizing tolerability, and managing comorbid anxiety or depression. Our aim was to investigate the treatment effect and tolerability profile of desvenlafaxine, and to examine the functionality of women with postpartum depression or anxiety after desvenlafaxine treatment. Methods: Fifteen postpartum women with depression or anxiety completed this 12-week prospective pilot study with a flexible dose of desvenlafaxine (50–100 mg). Participants were recruited at a tertiary care level program. Measures of depression (Montgomery–Åsberg Depression Rating Scale, MADRS), anxiety (Hamilton Anxiety Rating Scale, HAM-A), worry (Penn State Worry Questionnaire, PSWQ) and functional impairment (Sheehan Disability Scale, SDS) were completed at baseline, 8 weeks, and 12 weeks. Results: In the intention-to-treat analysis ( n = 17), the majority of women responded to medication (88.2%, n = 15), and reached remission of depressive (82.4%, n = 14) and anxiety symptoms (82.4%, n = 14). Remission of depression was achieved in a mean of 6.9 weeks [standard deviation (SD) = 3.01] at a mean dose of 71 mg/day (SD = 25.7). Significant decreases were observed on PSWQ worry scores ( p < 0.0001) and SDS scores for social ( p < 0.0001) and family life impairment ( p < 0.0001). The medication was generally well tolerated. Conclusion: The results of our prospective pilot study suggest that treatment with desvenlafaxine of postpartum mothers with depression or anxiety can lead to symptom remission and restoration of functionality.
Comparison of left ventricular ejection fraction values obtained using invasive contrast left ventriculography, two-dimensional echocardiography, and gated single-photon emission computed tomography
Authors: Garg Nadish , Dresser Thomas , Aggarwal Kul , Gupta Vishal , Mittal Mayank K , Alpert Martin A 
Published: June 2016

Objectives: Left ventricular ejection fraction can be measured by a variety of invasive and non-invasive cardiac techniques. This study assesses the relation of three diagnostic modalities to each other in the measurement of left ventricular ejection fraction: invasive contrast left ventriculography, two-dimensional echocardiography, and quantitative gated single-photon emission computed tomography. Methods: Retrospective chart review was conducted on 58 patients hospitalized with chest pain, who underwent left ventricular ejection fraction evaluation using each of the aforementioned modalities within a 3-month period not interrupted by myocardial infarction or revascularization. Results: The mean left ventricular ejection fraction values were as follows: invasive contrast left ventriculography (0.44±0.15), two-dimensional echocardiography (0.46±0.13), and gated single-photon emission computed tomography (0.37±0.10). Correlations coefficients and associated p values were as follows: invasive contrast left ventriculography versus two-dimensional echocardiography (r=0.69, p<0.001), invasive contrast left ventriculography versus gated single-photon emission computed tomography (r=0.80, p<0.0001), and gated single-photon emission computed tomography versus two-dimensional echocardiography (r=0.69, p<0.001). Conclusion: Our results indicate that strong positive correlations exist among the three techniques studied.
The quality of transitions from hospital to home: A hospital-based cohort study of patient groups with high and low readmission rates
Authors: Braet Anja , Weltens Caroline , Bruyneel Luk , Sermeus Walter 
Published: June 2016

Introduction The quality of transitions from the hospital to home is critical for preventing readmissions. The aims of this study were to evaluate variations in the quality of transitions across groups of patients and across hospitals with high and low readmission rates and to study the impact of transitions on postdischarge outcomes. Methods A multicenter cohort study was conducted at 12 Flemish hospitals between June 2013 and September 2015 to examine transitions for patients with heart failure, pneumonia, or total hip/knee arthroplasty. Hospitals with high and low readmission rates were selected based on readmission rates in 2008. The quality of the transitions was assessed based on readiness for discharge, patient education, general practitioner contributions to the discharge process, and timeliness and completeness of discharge summaries. Results A total of 233 patients were included in the study. Readiness for discharge was better in patients with total hip/knee arthroplasty than in those with heart failure or pneumonia (mean differences 11.1 (95% CI 5.3–16.9) ( p = 0.001) and 5.8 (95% CI 1.2–10.5) ( p = 0.016), respectively). Heart failure patients had better readiness scores in low readmission rates than in high readmission rates hospitals (mean difference 13.5 (95% CI 2.5–24.5)) ( p = 0.017). Insufficient timeliness of discharge summaries was a risk factor for postdischarge events (OR 10.564; 95% CI 1.476–75.603; p = 0.019). Discussion To improve the quality of transitions from hospital to home, communication with general practitioner s must occur in a timely manner and with a focus on the continuity of care. Particularly, in patients with complex postdischarge needs, preparing patients for discharge is essential to prevent readmissions.
Online support system for students in higher education: Proof-of-concept study
Authors: Touloumakos Anna K , Goozée Rhianna , Papadatou-Pastou Marietta , Barley Elizabeth , Haddad Mark , Tzotzoli Patapia 
Published: June 2016

Background Providing support to the increasing numbers of students facing mental health difficulties in higher education (HE) can be difficult due to stigma or lack of resources. Alternative and/or complementary sources of support are needed, such as online interventions that are recognised for their therapeutic value and cost-effectiveness. Objectives We aim to provide evidence supporting the conceptual and practical value of a newly developed online multimedia intervention system for HE students who face mild to moderate symptoms of anxiety and depression and study-skills difficulties. Methods Students from five universities were invited to participate in a cross-sectional proof-of-concept study. Students were invited through the universities’ internal communication channels. Following demonstration of each part of the system, students completed a survey with quantitative and qualitative questions. Results Response was largely positive. Positive responses on the features of the questionnaire ranged between 65% and 86%; on the features of the workshops ranged between 57% and 91%; on ‘My place’ ranged between 65% and 79%; on the animated videos ranged between 79% and 92%; and on the overall system ranged between 78% and 89%. Participants indicated areas for improvement and ways in which such improvement could be accomplished; these then guided the development of the system. Conclusions The results confirm the need for such a system. It can complement student support services (SSS) by dealing with cases with mild to moderate difficulties, hence allowing SSS to prioritise and effectively address more severe cases. Potentially this method can provide a meaningful alternative to SSS; this is worth investigating further.
Probability of finding at least one euploid embryo and the euploidy rate according to the number of retrieved oocytes and female age using FISH and array CGH
Authors: Kahraman Semra , Çil Aylin Pelin , Oğur Çağrı , Semiz Altug , Yilanlioglu Cihangir 
Published: June 2016

Objective: To assess the probability of finding at least one euploid embryo (POE) and euploidy rate in preimplantation genetic screening (PGS) cycles for aneuploidy testing with fluorescent in situ hybridization (FISH) and array comparative genomic hybridization (aCGH) based on the number of retrieved oocytes after adjustment for age. Design: Retrospective data analysis. Setting: Private in vitro fertilization center in a general hospital, Istanbul, Turkey. Patient(s): In this study, 1412 couples with 1739 cycles were included. Intervention(s): Embryo biopsy at cleavage stage or trophectoderm biopsy analyzed by FISH or aCGH techniques. Main outcome measure(s): Probability of finding at least one euploid embryo for transfer and euploidy rate according to retrieved oocytes after adjustment for age. Result(s): Estimated probabilities of finding at least one euploid embryo were plotted based on age and number of retrieved oocytes. When controlled for age, the POE increased with each additional oocyte retrieved (OR 1.11, 95% CI 1.08–1.14), but the euploidy rate did not. When retrieved oocytes were subgrouped, we found that the odds of finding at least one euploidy embryo were highest when 16–20 oocytes were retrieved compared to 1–5 oocytes with both FISH (OR 8.62, 95% CI 4.67–15.93) and aCGH (OR 2.78, 95% CI 1.07–7.21). However, the chances did not increase with the retrieval of more than 20 oocytes. Conclusion(s): The estimated probabilities of finding at least one transferrable embryo would enable more accurate counselling of patients based on age and the number of retrieved oocytes. As the highest estimates for finding one euploidy embryo were achieved with 15-20 oocytes, deciding the best protocol for ovarian stimulation to achieve the maximum number of oocytes for retrieval based on the patients age and ovarian reserve would be of crucial importance.
Regulation of EBV LMP1-triggered EphA4 downregulation in EBV-associated B lymphoma and its impact on patients’ survival
Authors: Huang Ya-Chi , Lin Sue-Jane , Lin Kai-Min , Chou Ya-Ching , Lin Chung-Wu , Yu Shan-Chi , Chen Chi-Long , Shen Tang-Long , Chen Chi-Kuan , Lu Jean , Chen Mei-Ru , Tsai Ching-Hwa 
Published: June 2016

Key Points
EBV LMP1 dysregulates EphA4 expression via the ERK-Sp1 pathway. Downregulation of EphA4 is demonstrated in EBV+ DLBCL, which is significantly correlated with poor DLBCL survival.
Targeting Epstein-Barr virus–transformed B lymphoblastoid cells using antibodies with T-cell receptor–like specificities
Authors: Lai Junyun , Tan Wei Jian , Too Chien Tei , Choo Joanna Ai Ling , Wong Lan Hiong , Mustafa Fatimah Bte , Srinivasan Nalini , Lim Angeline Pei Chiew , Zhong Youjia , Gascoigne Nicholas R. J. , Hanson Brendon J. , Chan Soh Ha , Chen Jianzhu , MacAry Paul A. 
Published: June 2016

Key PointsAnti-EBV TCR-like monoclonal antibodies reduce BLCLs tumor load in vivo. Anti-EBV TCR-like monoclonal antibodies mediate phagocytosis of BLCLs by macrophages.
A 1-day visit in a severe asthma centre: effect on asthma control, quality of life and healthcare use
Authors: van der Meer Akke-Nynke , Pasma Henk , Kempenaar-Okkema Wilma , Pelinck Jo-Anneke , Schutten Myrte , Storm Huib , ten Brinke Anneke 
Published: June 2016

Patients with uncontrolled asthma report ongoing symptoms, poor quality-of-life and extensive healthcare use (HCU) and might benefit from management by a specialised severe asthma team. It is unknown whether a one-time evaluation by asthma experts, without long-term supervision by a specialised team, provides favourable outcomes. We evaluated asthma control (Asthma Control Questionnaire; ACQ), quality-of-life (Asthma-related Quality of Life Questionnaire; AQLQ) and HCU before and 1 year after a 1-day visit programme in a severe asthma centre, including a multidisciplinary assessment resulting in a personalised management plan to be implemented by patients own pulmonologists.40 uncontrolled asthma patients completed questionnaires (ACQ, AQLQ, HCU) at baseline, and 6 and 12 months follow-up.ACQ improved from 2.6 (interquartile range 1.7–3.2) to 1.8 (1.2–3.2) (p=0.003) and AQLQ from 4.8 (4.0–5.2) to 5.3 (4.4–6.0) (p<0.001). We found a reduction in patients with ≥2 exacerbations (95%versus17%; p<0.001), ≥1 emergency room visit (78%versus37%; p<0.001) and ≥1 hospitalisation (47%versus10%; p=0.001).Evaluation of uncontrolled asthma patients in a 1-day visit programme in a severe asthma centre resulted in significant improvements in asthma control, quality-of-life and healthcare use after 1 year. This 1-day visit approach seems beneficial for uncontrolled asthma patients and might reduce their dependence on expensive treatment modalities and long-term management in specialised centres.
Health-related quality of life in elderly patients with advanced non-small cell lung cancer comparing carboplatin and weekly paclitaxel doublet chemotherapy with monotherapy
Authors: Fiteni Frédéric , Anota Amélie , Bonnetain Franck , Oster Jean-Philippe , Pichon Eric , Wislez Marie , Dauba Jérôme , Debieuvre Didier , Souquet Pierre-Jean , Bigay-Game Laurence , Molinier Olivier , Dansin Eric , Poudenx Michel , Milleron Bernard , Morin Franck , Zalcman Gérard , Quoix Elisabeth , Westeel Virginie 
Published: June 2016

In theIntergroupe Francophone de Cancérologie Thoracique0501 trial the carboplatin-paclitaxel chemotherapy increased toxicity (most frequent, decreased neutrophil count, asthenia). We longitudinally compared health-related quality of life (HRQoL) of the two treatment arms.In total, 451 patients aged 70–89 years with advanced non-small cell lung cancer (NSCLC) were randomly assigned to receive carboplatin plus paclitaxel or vinorelbine or gemcitabine. HRQoL was assessed by means of the European Organisation for Research and Treatment of Cancer QLQ-C30 questionnaire at baseline, week 6 and week 18.Using a five-point decrease as the minimal clinically important difference, patients treated with the chemotherapy doublet exhibited a significant longer time until definitive deterioration (TUDD) for two HRQoL dimensions: physical functioning (median TUDD: 2.04 for the doubletversus1.71 months for monotherapy; log-rank p=0.01) and nausea and vomiting (median: not reachedversus4.83, respectively; log-rank p=0.046). Cox multivariate analysis revealed the carboplatin and paclitaxel arm to be independently associated with longer TUDD for these two HRQoL dimensions. In addition, TUDD didn't significantly differ between the two arms for all the other HRQoL dimensions.The chemotherapy doublet did not reduce TUDD in elderly patients with advanced NSCLC. Moreover, TUDD was prolonged for two HRQoL dimensions, namely physical functioning and nausea and vomiting.
Fate of S2-Alar-Iliac Screws After 12-Month Minimum Radiographic Follow-up: Preliminary Results
Authors: Mazur Marcus D. , Mahan Mark A. , Shah Lubdha M. , Dailey Andrew T. 
Published: June 2016

Abstract

BACKGROUND: S2-alar-iliac (S2AI) screws are 1 technique for lumbopelvic fixation to improve fusion rates across the lumbosacral junction that has gained wider acceptance. The S2AI screw crosses the cortical surfaces of the sacroiliac joint (SIJ), which may improve the biomechanical strength of the instrumentation.

OBJECTIVE: To report preliminary radiographic outcomes of patients who underwent lumbopelvic fixation with S2AI screws with a minimum 12-month follow-up.

METHODS: We retrospectively reviewed adult patients who underwent lumbopelvic fixation with S2AI screws. Patients with computed tomography (CT) scans obtained preoperatively and ≥12 months postoperatively were reviewed to determine whether there was S2AI screw backout or breakage, periscrew lucency, or SIJ degeneration, and to assess L5-S1 fusion status.

RESULTS: Twenty-six S2AI screws in 13 patients were evaluated (mean follow-up 24.8 months [14-52 months]). Nine patients had L5-S1 interbody grafts. Partial periscrew lucency was identified in 7 S2AI screws (27%) in 5 patients (38%), and L5-S1 fusion occurred in 92% of patients. L5-S1 nonunion was seen in 1 patient (8%), who had evidence of bilateral screw loosening in the sacral portion. Four patients with screw loosening had an osseous L5-S1 fusion. No patients had radiographic evidence of progression of SIJ degeneration, experienced screw backout or breakage, required reoperation for L5-S1 nonunion, or had S2AI screw-related complication.

CONCLUSION: S2AI screws maintained their integrity without causing SIJ degeneration or major screw-related complications in this small retrospective series with short follow-up. Long-term results are needed to evaluate the durability of S2AI screws over time.
‘Rod and ring’ formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway
Authors: Calise S. John , Purich Daniel L. , Nguyen Thuy , Saleem Dania A. , Krueger Claire , Yin Joyce D. , Chan Edward K. L. 
Published: June 2016

ABSTRACT
‘Rods and rings’ (RRs) are conserved, non-membrane-bound intracellular polymeric structures composed, in part, of inosine monophosphate dehydrogenase (IMPDH), a key enzyme leading to GMP and GTP biosynthesis. RR formation is induced by IMPDH inhibitors as well as glutamine deprivation. They also form upon treatment of cells with glutamine synthetase inhibitors. We now report that depriving cells of serine and glycine promotes RR formation, and we have traced these effects to dihydrofolate reductase (DHFR) and serine hydroxymethyltransferase-2 (SHMT2), pivotal enzymes in one-carbon metabolism and nucleotide biosynthesis. RR assembly is likewise induced upon DHFR inhibition by methotrexate or aminopterin as well as siRNA-mediated knockdown of DHFR or SHMT2. Because RR assembly occurs when guanine nucleotide biosynthesis is inhibited, and because RRs rapidly disassemble after the addition of guanine nucleotide precursors, RR formation might be an adaptive homeostatic mechanism, allowing IMPDH to sense changes in the one-carbon folate pathway.
Nomenclatural notes on four Linnaean names in Arenaria (Caryophyllaceae)
Authors: Iamonico Duilio 
Published: June 2016

AbstractThe Linnaean names Arenaria laricifolia, Ar. liniflora, Ar. mucronata, and Ar. striata (Caryophyllaceae) are investigated. Specimens from the Linnaean Herbarium (LINN) are designated as lectotypes of Ar. laricifolia and Ar. liniflora, a specimen from UPS is designated as lectotype for Ar. striata, and an illustration by Haller is designated as lectotype for Ar. mucronata. These names are currently recognized under Minuartia s.l. and can be referred to Cherleria laricifolia comb.nov.s.str. (≡ Ar. laricifolia; Ar. liniflora and Ar. striata being later heterotypic synonyms) or M. mucronata (= Ar. mucronata). Two names (Stellaria rubra, Ar. fastigiata) are proposed as new heterotypic synonyms of M. mucronata (Ar. fastigiata is lectotypified on a Smith's illustration). It is also noted that "Arenaria cerastoides L." is a nomen nudum and so not validly published under Art. 38.1 of the ICN; its intended identity is, therefore, irrelevant. According to the current concept in Minuartia, M. laricifolia should be treated under the genus Cherleria and, lacking a nomenclatural transfer, I here propose three new combinations each for one of the three subspecies currently recognized: C. laricifolia subsp. laricifolia comb. nov., C. laricifolia subsp. kitaibelii comb. nov. and C. laricifolia subsp. ophiolitica comb. nov.
The borage family (Boraginaceae s.str.): A revised infrafamilial classification based on new phylogenetic evidence, with emphasis on the placement of some enigmatic genera
Authors: Chacón Juliana , Luebert Federico , Hilger Hartmut H. , Ovchinnikova Svetlana , Selvi Federico , Cecchi Lorenzo , Guilliams C. Matt , Hasenstab-Lehman Kristen , Sutorý Karel , Simpson Michael G. , Weigend Maximilian 
Published: June 2016

AbstractBoraginaceae s.str. is a subcosmopolitan family of 1600 to 1700 species in around 90 genera, and recent phylogenetic studies indicate that the infrafamilial classification as currently used is highly obsolete. The present study addresses the relationships of the major clades in Boraginaceae s.str. with an emphasis on monophyly of, and relationships between previously recognized clades and the position of various unplaced genera such as Afrotysonia, Anoplocaryum, Brachybotrys, Chionocharis, Craniospermum, Thyrocarpus, and Trigonocaryum using three plastid markers and a taxon sampling with four outgroup and 170 ingroup species from 73 genera. The phylogeny shows high statistical support for most nodes on the backbone and within individual clades. Echiochileae are confirmed as sister to the remainder of Boraginaceae s.str., which, in turn, fall into two well‐supported clades, the Boragineae + Lithospermeae and the Cynoglosseae s.l. The latter is highly resolved and includes the Lasiocaryum‐clade (Chionocharis, Lasiocaryum, Microcaryum) and the Trichodesmeae (Caccinia, Trichodesma) as sister to the remainder of the group. Rochelieae (formerly the Eritrichieae s.str., also including Eritrichium, Hackelia, and Lappula) form a poorly supported polytomy together with the Mertensia‐clade (also including Anoplocaryum, Asperugo, and Memoremea) and the Omphalodes‐clade. The enigmatic genus Craniospermum (Craniospermeae) is sister to an expanded Myosotideae (also including Brachybotrys, Decalepidanthus, Trigonocaryum, and Trigonotis) and these two clades are in turn sister to the Core‐Cynoglosseae, in which Afrotysonia glochidiata and Thyrocarpus sampsonii are included. Core‐Cynoglosseae again fall into two pairs of well‐supported subclades. The majority of generic placements are now resolved satisfactorily and the remaining phylogenetic questions can be clearly delimited. Based on the extensive phylogenetic data now available we propose a new infrafamilial classification into three subfamilies and 11 tribes, representing a consensus among the participating authors, according to which major clades are renamed.
Phylogeny of Apiaceae subtribe Daucinae and the taxonomic delineation of its genera
Authors: Banasiak Łukasz , Wojewódzka Aneta , Baczyński Jakub , Reduron Jean-Pierre , Piwczyński Marcin , Kurzyna-Młynik Renata , Gutaker Rafał , Czarnocka-Cieciura Agnieszka , Kosmala-Grzechnik Sylwia , Spalik Krzysztof 
Published: June 2016

AbstractScandiceae subtribe Daucinae encompasses umbellifers that have fruits with prominent secondary ridges projecting into wings (former tribe Laserpitieae) or spines (former tribe Caucalideae pro parte). It comprises several economically or medicinally important genera including Cuminum, Daucus, Laser, Laserpitium and Thapsia among others. Recent molecular studies, based mostly on nrDNA ITS sequences, revealed that neither Daucus nor Laserpitium are monophyletic. To address issues of relationships and apply respective nomenclatural changes, we obtained additional ITS sequences as well as independent data from three plastid markers—rps16 intron, rpoC1 intron and rpoB‐trnC intergenic spacer—for a comprehensive sample of the subtribe. We examined data for 260 accessions representing all genera of Daucinae and 81 of its ca. 93 species. Phylogenetic trees were estimated using maximum likelihood and Bayesian inference methods. The results indicate that former Laserpitieae constitute a paraphyletic grade at the base of the spiny‐fruited members of Daucinae while traditionally delimited Daucus and Laserpitium are polyphyletic. To maintain a monophyletic Daucus, we suggest including the following genera and species into its synonymy: Agrocharis, Melanoselinum, Monizia, Pachyctenium, Pseudorlaya, Rouya, Tornabenea, Athamanta dellacellae and Cryptotaenia elegans. The species of Laserpitium occur in seven clades and only six species of the Laserpitium s.str. clade retain the generic name. Several species are transferred to Ekimia, Laser and Thapsia; additionally, a monospecific genus Siler is restored and a new genus, Silphiodaucus, is established. The inclusion of Ammodaucus into Thapsia suggested in an earlier study is not supported. The position of Laserpitium pseudomeum requires further study.