bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cornea-Derived Mesenchymal Stromal Cells Therapeutically Modulate Macrophage Immunophenotype and Angiogenic Function
Authors: Eslani Medi , Putra Ilham , Shen Xiang , Hamouie Judy , Tadepalli Asha , Anwar Khandaker N. , Kink John A. , Ghassemi Samaneh , Agnihotri Gaurav , Reshetylo Sofiya , Mashaghi Alireza , Dana Reza , Hematti Peiman , Djalilian Ali R. 
Published: January 2018

Abstract
Macrophages are crucial drivers of inflammatory corneal neovascularization and thus are potential targets for immunomodulatory therapies. We hypothesized that therapeutic use of cornea-derived mesenchymal stromal cells (cMSCs) may alter the function of macrophages. We found that cMSCs can modulate the phenotype and angiogenic function of macrophages. In vitro, cMSCs induce apoptosis of macrophages while preferentially promoting a distinct CD14hiCD16hiCD163hiCD206hi immunophenotype that has significantly reduced angiogenic effects based on in vitro angiogenesis assays. In vivo, application of cMSCs to murine corneas after injury leads to reduced macrophage infiltration and higher expression of CD206 in macrophages. Macrophages cocultured (“educated”) by cMSCs express significantly higher levels of anti-angiogenic and anti-inflammatory factors compared with control macrophages. In vivo, injured corneas treated with cMSC-educated macrophages demonstrate significantly less neovascularization compared with corneas treated with control macrophages. Knocking down the expression of pigment epithelial derived factor (PEDF) in cMSCs significantly abrogates its modulating effects on macrophages, as shown by the reduced rate of apoptosis, decreased expression of sFLT-1/PEDF, and increased expression of vascular endothelial growth factor-A in the cocultured macrophages. Similarly, cMSCs isolated from PEDF knockout mice are less effective compared with wild-type cMSCs at inhibiting macrophage infiltration when applied to wild-type corneas after injury. Overall, these results demonstrate that cMSCs therapeutically suppress the angiogenic capacity of macrophages and highlight the role of cMSC secreted PEDF in the modulation of macrophage phenotype and function.
Wind turbine sensor array for monitoring avian and bat collisions
Authors: Hu Congcong , Albertani Roberto , Suryan Robert M. 
Published: January 2018

AbstractAssessment of avian and bat collisions with wind turbines is necessary to ensure that the benefits of renewable wind power generation are not outweighed by mortality of protected species. An onboard, integrated multisensor system capable of providing detection of turbine collision events, including taxonomic information, was developed. The conceptual design of a multisensor system including a vibration sensing node, an optics node, and an bioacoustic node with an event‐driven trigger architecture was field‐tested on utility‐scale wind turbines. A pixel density computational model was built to estimate the spatial coverage and target resolution to the optimized configuration for camera placement. Field test results of the vibration node showed that nearly half of the recorded impact events were successfully identified by visual inspection and running short‐time Fourier transform on recorded vibration signals. The remaining undetected impact events were masked under background noise due to low impact energy and high background noise of the operating turbine, which result in subsequent low signal‐to‐noise ratio. Our results demonstrate the feasibility of triggering the system through single impact event sensed by vibration sensors.
A survey of incremental high‐utility itemset mining
Authors: Gan Wensheng , Lin Jerry Chun‐Wei , Fournier‐Viger Philippe , Chao Han‐Chieh , Hong Tzung‐Pei , Fujita Hamido 
Published: January 2018

Traditional association rule mining has been widely studied. But it is unsuitable for real‐world applications where factors such as unit profits of items and purchase quantities must be considered. High‐utility itemset mining (HUIM) is designed to find highly profitable patterns by considering both the purchase quantities and unit profits of items. However, most HUIM algorithms are designed to be applied to static databases. But in real‐world applications such as market basket analysis and business decision‐making, databases are often dynamically updated by inserting new data such as customer transactions. Several researchers have proposed algorithms to discover high‐utility itemsets (HUIs) in dynamically updated databases. Unlike batch algorithms, which always process a database from scratch, incremental high‐utility itemset mining (iHUIM) algorithms incrementally update and output HUIs, thus reducing the cost of discovering HUIs. This paper provides an up‐to‐date survey of the state‐of‐the‐art iHUIM algorithms, including Apriori‐based, tree‐based, and utility‐list‐based approaches. To the best of our knowledge, this is the first survey on the mining task of incremental high‐utility itemset mining. The paper also identifies several important issues and research challenges for iHUIM. WIREs Data Mining Knowl Discov 2018, 8:e1242. doi: 10.1002/widm.1242This article is categorized under:

Algorithmic Development > Association Rules
Application Areas > Data Mining Software Tools
Fundamental Concepts of Data and Knowledge > Knowledge Representation
Have You Ever Googled a Patient or Been Friended by a Patient? Social Media Intersects the Practice of Genetic Counseling
Authors: Omaggio NinaMarie F. , Baker Maria J. , Conway Laura J. 
Published: January 2018

AbstractPatients and healthcare providers are becoming increasingly connected via social media, bringing new opportunities and challenges. Direct connection can occur between patients and providers using online tools such as Facebook and LinkedIn. In addition, providers can gather information about patients using a search engine such as Google, referred to as patient‐targeted Googling (PTG). An online 54‐item survey was used to gain information on (1) how and to what extent genetic counseling students and genetic counselors connect directly with patients via social media sites, and (2) gather information on providers using PTG. Four hundred genetic counseling students and genetic counselors participated in the survey. The majority of respondents (88.9%; n = 344/387) find it is never or rarely acceptable to interact with current patients via social media sites; however, 27.7% (n = 110/397) have visited a patient's social media site. Gathering information for patient care was the most commonly reported reason (76.8%; n = 43/56). Thirty‐three percent (n = 130/394) have considered searching online or actually searched online for information about a patient. Curiosity was the most common reason (92.7%; n = 114/123); although, respondents also used PTG to obtain contact information and to prepare for patient sessions. Our study supports the need for development and dissemination of professional guidelines to serve as a valuable resource for practicing genetic counselors and genetic counseling training programs.
Petrogenesis of the Late Cenozoic collision volcanism in the central part of the Lesser Caucasus (Azerbaijan)
Authors: Imamverdiyev N.A. , Gasangulieva M.Ya. , Babaeva G.J. , Abdullaeva Sh.F. , Veliev A.A. 
Published: January 2018

Abstract
The Late Cenozoic volcanics of the Lesser Caucasus have similar trace-element and REE patterns with negative anomalies of Nb, Ta, Hf, and Zr. They are highly enriched in Rb, Ba, Th, and La and depleted in Ti, Yb, and Y with respect to N-MORB, which indicates their formation from the subduction-metasomatized lithospheric mantle. Partial melting of the subcontinental mantle lithosphere and crustal assimilation and fractional crystallization controlled the magma evolution in the collisional magmatic belts.
The Upper Ordovician of northeastern Gorny Altai: Stratigraphy and deposition environments
Authors: Sennikov N.V. , Obut O.T. , Tolmacheva T.Yu. , Lykova E.V. , Khabibulina R.A. 
Published: January 2018

Abstract
Comprehensive lithofacies and biofacies analysis provided constraints on the origin of Upper Ordovician clastic and carbonate deposits in northeastern Gorny Altai, which form large low-elevated flat carbonate banks located relatively close to the shore. The sediments were deposited during the Sandbian and early–middle Katian stages, according to new conodont data. Upper Ordovician sections in northeastern Gorny Altai store record of two global regressions: the early Sandbian (Vollen Lowstand) and early Katian (Frognerkilen Lowstand) events.
How gender- and violence-related norms affect self-esteem among adolescent refugee girls living in Ethiopia
Authors: Stark L. , Asghar K. , Seff I. , Cislaghi B. , Yu G. , Tesfay Gessesse T. , Eoomkham J. , Assazenew Baysa A. , Falb K. 
Published: January 2018

Background.Evidence suggests adolescent self-esteem is influenced by beliefs of how individuals in their reference group perceive them. However, few studies examine how gender- and violence-related social norms affect self-esteem among refugee populations. This paper explores relationships between gender inequitable and victim-blaming social norms, personal attitudes, and self-esteem among adolescent girls participating in a life skills program in three Ethiopian refugee camps.Methods.Ordinary least squares multivariable regression analysis was used to assess the associations between attitudes and social norms, and self-esteem. Key independent variables of interest included a scale measuring personal attitudes toward gender inequitable norms, a measure of perceived injunctive norms capturing how a girl believed her family and community would react if she was raped, and a peer-group measure of collective descriptive norms surrounding gender inequity. The key outcome variable, self-esteem, was measured using the Rosenberg self-esteem scale.Results.Girl's personal attitudes toward gender inequitable norms were not significantly predictive of self-esteem at endline, when adjusting for other covariates. Collective peer norms surrounding the same gender inequitable statements were significantly predictive of self-esteem at endline (ß = −0.130;p = 0.024). Additionally, perceived injunctive norms surrounding family and community-based sanctions for victims of forced sex were associated with a decline in self-esteem at endline (ß = −0.103;p = 0.014). Significant findings for collective descriptive norms and injunctive norms remained when controlling for all three constructs simultaneously.Conclusions.Findings suggest shifting collective norms around gender inequity, particularly at the community and peer levels, may sustainably support the safety and well-being of adolescent girls in refugee settings.
Relocation of clustered earthquakes in the Groningen gas field
Authors: Jagt Lisanne , Ruigrok Elmer , Paulssen Hanneke 
Published: January 2018

AbstractPrevious locations of earthquakes induced by depletion of the Groningen gas field were not accurate enough to infer which faults in the reservoir are reactivated. A multiplet analysis is performed to identify clusters of earthquakes that have similar waveforms, representing repeating rupture on the same or nearby faults. The multiplet analysis is based on the cross-correlation of seismograms to assess the degree of similarity. Using data of a single station, six earthquake clusters within the limits of the Groningen field were identified for the period 2010 to mid-2014. Four of these clusters were suitable for a relocation method that is based on the difference in travel time between the P- and the S-wave. Events within a cluster can be relocated relative to a master event with improved accuracy by cross-correlating first arrivals. By choosing master events located with a new dense seismic network, the relocated events likely not only have better relative, but also improved absolute locations. For a few clusters with sufficient signal-to-noise detections, we show that the relocation method is successful in assigning clusters to specific faults at the reservoir level. Overall, about 90% of the events did not show clustering, despite choosing low correlation thresholds of 0.5 and 0.6. This suggests that different faults and/or fault segments with likely varying source mechanisms are active in reservoir sub-regions of a few square kilometres.
History match of the Groningen field dynamic reservoir model to subsidence data and conventional subsurface data
Authors: van Oeveren Hendrik , Valvatne Per , Geurtsen Leendert , van Elk Jan 
Published: January 2018

AbstractThis paper presents the method applied to history-match the Groningen field dynamic model to conventional data (pressure data and water influx data) and to subsidence data, which is a novelty. Modelled subsidence is matched to subsidence data based on a simplified geomechanical model, which was built into the dynamic simulator.A two-tier method was used to first achieve a match on a field-wide scale using field-average history-match quantifiers, which was then further improved at a regional/well level using regional history-match quantifiers. The history match was assisted by a space-filling experimental design. The resulting model has a field-average match to pressure data of ±2.17bar with a measurement uncertainty of ±0.4bar, to water influx data of ±2m with a measurement uncertainty of ±0.5m, and to subsidence data of ±4cm with a measurement uncertainty of ±1cm.The output from this model is used as input for compaction, subsidence and production forecasts feeding into the hazard and risk assessment completed by NAM for the Groningen Winningsplan 2016.
Field-wide reservoir compressibility estimation through inversion of subsidence data above the Groningen gas field
Authors: van Eijs Rob M.H.E. , van der Wal Onno 
Published: January 2018

AbstractNot long after discovery of the Groningen field, gas-production-induced compaction and consequent land subsidence was recognised to be a potential threat to groundwater management in the province of Groningen, in addition to the fact that parts of the province lie below sea level. More recently, NAM's seismological model also pointed to a correlation between reservoir compaction and the observed induced seismicity above the field. In addition to the already existing requirement for accurate subsidence predictions, this demanded a more accurate description of the expected spatial and temporal development of compaction.Since the start of production in 1963, multiple levelling campaigns have gathered a unique set of deformation measurements used to calibrate geomechanical models. In this paper we present a methodology to model compaction and subsidence, combining results from rock mechanics experiments and surface deformation measurements. Besides the optical spirit-levelling data, InSAR data are also used for inversion to compaction and calibration of compaction models. Residual analysis, i.e. analysis of the difference between measurement and model output, provides confidence in the model results used for subsidence forecasting and as input to seismological models.
Hazard and risk assessments for induced seismicity in Groningen
Authors: van Elk Jan , Doornhof Dirk , Bommer Julian J. , Bourne Stephen J. , Oates Steve J. , Pinho Rui , Crowley Helen 
Published: January 2018

AbstractEarthquakes associated with gas production have been recorded in the northern part of the Netherlands since 1986. The Huizinge earthquake of 16 August 2012, the strongest so far with a magnitude ofML= 3.6, prompted reassessment of the seismicity induced by production from the Groningen gas field. An international research programme was initiated, with the participation of many Dutch and international universities, knowledge institutes and recognised experts.The prime aim of the programme was to assess the hazard and risk resulting from the induced seismicity. Classic probabilistic seismic hazard and risk assessment (PSHA) was implemented using a Monte Carlo method. The scope of the research programme extended from the cause (production of gas from the underground reservoir) to the effects (risk to people and damage to buildings). Data acquisition through field measurements and laboratory experiments was a substantial element of the research programme. The existing geophone and accelerometer monitoring network was extended, a new network of accelerometers in building foundations was installed, geophones were placed at reservoir level in deep wells, GPS stations were installed and a gravity survey was conducted.Results of the probabilistic seismic hazard and risk assessment have been published in production plans submitted to the Minister of Economic Affairs, Winningsplan Groningen 2013 and 2016 and several intermediate updates. The studies and data acquisition further constrained the uncertainties and resulted in a reduction of the initially assessed hazard and risk.
Geomechanical models for induced seismicity in the Netherlands: inferences from simplified analytical, finite element and rupture model approaches
Authors: Van Wees Jan-Diederik , Fokker Peter A. , Van Thienen-Visser Karin , Wassing Brecht B.T. , Osinga Sander , Orlic Bogdan , Ghouri Saad A. , Buijze Loes , Pluymaekers Maarten 
Published: January 2018

AbstractIn the Netherlands, over 190 gas fields of varying size have been exploited, and 15% of these have shown seismicity. The prime cause for seismicity due to gas depletion is stress changes caused by pressure depletion and by differential compaction. The observed onset of induced seismicity due to gas depletion in the Netherlands occurs after a considerable pressure drop in the gas fields. Geomechanical studies show that both the delay in the onset of induced seismicity and the nonlinear increase in seismic moment observed for the induced seismicity in the Groningen field can be explained by a model of pressure depletion, if the faults causing the induced seismicity are not critically stressed at the onset of depletion. Our model shows concave patterns of log moment with time for individual faults. This suggests that the growth of future seismicity could well be more limited than would be inferred from extrapolation of the observed trend between production or compaction and seismicity. The geomechanical models predict that seismic moment increase should slow down significantly immediately after a production decrease, independently of the decay rate of the compaction model. These findings are in agreement with the observed reduced seismicity rates in the central area of the Groningen field immediately after production decrease on 17 January 2014. The geomechanical model findings therefore support scope for mitigating induced seismicity by adjusting rates of production and associated pressure change. These simplified models cannot serve as comprehensive models for predicting induced seismicity in any particular field. To this end, a more detailed field-specific study, taking into account the full complexity of reservoir geometry, depletion history and mechanical properties, is required.
Calibrated density profiles of Caribbean mangrove peat sequences from computed tomography for assessment of peat preservation, compaction, and impacts on sea-level reconstructions
Authors: Toscano Marguerite A. , Gonzalez Juan L. , Whelan Kevin R.T. 
Published: January 2018

AbstractOceanic mangroves accumulate peat with sea-level rise without terrestrial sediment inputs, but fossil peat’s elevation as a tide-range limited sea-level indicator is assumed to be affected by compaction. Despite assumption of decomposition, compression, and dewatering, pure Rhizophora mangle peat appears coarse, water-saturated, and loose even at depth. Calibrated peat densities from computed tomography (CT) and petrologic analysis allow quantitative assessment of compaction in continuous peats from Florida (6 m thick), Belize (12 m thick), and Panama (3.5 m thick). Pure peat exhibits voids at all depths and >80% water contents. CT density does not increase with depth; bulk densities are low, minimally variable, and trend-free. Higher CT-density intervals coincide with compositional changes (sediment, coral). CT of peat buried under sediment shows a shift to higher densities. CT of air-dried continuous peat shows uncompressed fine and coarse roots and voids, with negative densities indicative of air in place of interstitial water. Peat’s high water content and hydraulic conductivity prevent dewatering and compaction, hypothetically maintaining original sea-level indicative elevations at intermediate depths. Non-compacted, sediment-free, offshore peats can provide a continuous proxy for reconstructing the record of sea-level rise at any site, if depositional, disturbance, and geochemical and biotic processes affecting 14C ages are also assessed.
Online market research panel members as controls in case–control studies to investigate gastrointestinal disease outbreaks: early experiences and lessons learnt from the UK
Authors: Mook P. , McCormick J. , Kanagarajah S. , Adak G. K. , Cleary P. , Elson R. , Gobin M. , Hawker J. , Inns T. , Sinclair C. , Trienekens S. C. M , Vivancos R. , McCarthy N.D. 
Published: January 2018

AbstractEstablished methods of recruiting population controls for case–control studies to investigate gastrointestinal disease outbreaks can be time consuming, resulting in delays in identifying the source or vehicle of infection. After an initial evaluation of using online market research panel members as controls in a case–control study to investigate aSalmonellaoutbreak in 2013, this method was applied in four further studies in the UK between 2014 and 2016. We used data from all five studies and interviews with members of each outbreak control team and market research panel provider to review operational issues, evaluate risk of bias in this approach and consider methods to reduce confounding and bias. The investigators of each outbreak reported likely time and cost savings from using market research controls. There were systematic differences between case and control groups in some studies but no evidence that conclusions on the likely source or vehicle of infection were incorrect. Potential selection biases introduced by using this sampling frame and the low response rate are unclear. Methods that might reduce confounding and some bias should be balanced with concerns for overmatching. Further evaluation of this approach using comparisons with traditional methods and population-based exposure survey data is recommended.
Parallel droplet microfluidics for high throughput cell encapsulation and synthetic microgel generation
Authors: Headen Devon M. , García José R. , García Andrés J. 
Published: January 2018

AbstractCells can be microencapsulated in synthetic hydrogel microspheres (microgels) using droplet microfluidics, but microfluidic devices with a single droplet generating geometry have limited throughput, especially as microgel diameter decreases. Here we demonstrate microencapsulation of human mesenchymal stem cells (hMSCs) in small (<100 μm diameter) microgels utilizing parallel droplet generators on a two-layer elastomer device, which has 600% increased throughput vs. single-nozzle devices. Distribution of microgel diameters were compared between products of parallel vs. single-nozzle configurations for two square nozzle widths, 35 and 100 μm. Microgels produced on parallel nozzles were equivalent to those produced on single nozzles, with substantially the same polydispersity. Microencapsulation of hMSCs was compared for parallel nozzle devices of each width. Thirty five micrometer wide nozzle devices could be operated at twice the cell concentration of 100 μm wide nozzle devices but produced more empty microgels than predicted by a Poisson distribution. Hundred micrometer wide nozzle devices produced microgels as predicted by a Poisson distribution. Polydispersity of microgels did not increase with the addition of cells for either nozzle width. hMSCs encapsulated on 35 μm wide nozzle devices had reduced viability (~70%) and a corresponding decrease in vascular endothelial growth factor (VEGF) secretion compared to hMSCs cultured on tissue culture (TC) plastic. Encapsulating hMSCs using 100 μm wide nozzle devices mitigated loss of viability and function, as measured by VEGF secretion.