bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flexible polyurethane foams formulated with polyols derived from waste carbon dioxide
Authors: DeBolt Mica , Kiziltas Alper , Mielewski Deborah , Waddington Simon , Nagridge Michael J. 
Published: July 2016

ABSTRACTIn this study, flexible polyurethane foam samples were prepared using concentrations of up to 50% of two novel polycarbonate polyols, Polyol D 251‐20 and Polyol D 351‐30, derived from the copolymerization of carbon dioxide (CO2) and epoxides, to determine whether the final foam products meet automotive standards for use in seating applications. In other words, CO2‐based polyols were substituted for a portion of petroleum‐based polyols in the foam formulations. Characterization of the foam samples was carried out by mechanical, physical, and thermal analysis. Overall, inclusion of both types of CO2‐based polyol led to an increase in wet compression set, compression modulus, compression stress at various strain levels, maximum tensile strength, Young's modulus, and tear resistance properties in the flexible polyurethane foams. Density, SAG factors, and elongation properties remained relatively constant compared to petroleum‐based control samples. Dynamic mechanical thermal analysis showed increasing storage modulus with increasing concentrations of CO2‐based polyol at temperatures below 0 °C. Thermogravimetric analysis showed that the thermal stability of the foam decreases with an increase in the concentration of CO2‐based polyol. Images of foam samples were taken using a Keyence VHX digital microscope. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44086.
Hippocampal lipid differences in Alzheimer's disease: a human brain study using matrix‐assisted laser desorption/ionization‐imaging mass spectrometry
Authors: Mendis Lakshini H. S. , Grey Angus C. , Faull Richard L. M. , Curtis Maurice A. 
Published: July 2016

AbstractIntroductionAlzheimer's disease (AD), the leading cause of dementia, is pathologically characterized by β‐amyloid plaques and tau tangles. However, there is also evidence of lipid dyshomeostasis‐mediated AD pathology. Given the structural diversity of lipids, mass spectrometry is a useful tool for studying lipid changes in AD. Although there have been a few studies investigating lipid changes in the human hippocampus in particular, there are few reports on how lipids change in each hippocampal subfield (e.g., Cornu Ammonis [CA] 1–4, dentate gyrus [DG] etc.). Since each subfield has its own function, we postulated that there could be lipid changes that are unique to each.MethodsWe used matrix‐assisted laser desorption/ionization‐imaging mass spectrometry to investigate specific lipid changes in each subfield in AD. Data from the hippocampus region of six age‐ and gender‐matched normal and AD pairs were analyzed with SCiLS lab 2015b software (SCiLS GmbH, Germany; RRID:SCR_014426), using an analysis workflow developed in‐house. Hematoxylin, eosin, and luxol fast blue staining were used to precisely delineate each anatomical hippocampal subfield. Putative lipid identities, which were consistent with published data, were assigned using MS/MS.ResultsBoth positively and negatively charged lipid ion species were abundantly detected in normal and AD tissue. While the distribution pattern of lipids did not change in AD, the abundance of some lipids changed, consistent with trends that have been previously reported. However, our results indicated that the majority of these lipid changes specifically occur in the CA1 region. Additionally, there were many lipid changes that were specific to the DG.ConclusionsMatrix‐assisted laser desorption/ionization‐imaging mass spectrometry and our analysis workflow provide a novel method to investigate specific lipid changes in hippocampal subfields. Future work will focus on elucidating the role that specific lipid differences in each subfield play in AD pathogenesis.
Functional Site Discovery in a Sulfur Metabolism Enzyme by Using Directed Evolution
Authors: Paritala Hanumantharao , Palde Prakash B. , Carroll Kate S. 
Published: July 2016

AbstractIn human pathogens, the sulfate assimilation pathway provides reduced sulfur for biosynthesis of essential metabolites, including cysteine and low‐molecular‐weight thiol compounds. Sulfonucleotide reductases (SRs) catalyze the first committed step of sulfate reduction. In this reaction, activated sulfate in the form of adenosine‐5′‐phosphosulfate (APS) or 3′‐phosphoadenosine 5′‐phosphosulfate (PAPS) is reduced to sulfite. Gene knockout, transcriptomic and proteomic data have established the importance of SRs in oxidative stress‐inducible antimicrobial resistance mechanisms. In previous work, we focused on rational and high‐throughput design of small‐molecule inhibitors that target the active site of SRs. However, another critical goal is to discover functionally important regions in SRs beyond the traditional active site. As an alternative to conservation analysis, we used directed evolution to rapidly identify functional sites in PAPS reductase (PAPR). Four new regions were discovered that are essential to PAPR function and lie outside the substrate binding pocket. Our results highlight the use of directed evolution as a tool to rapidly discover functionally important sites in proteins.
Acute cholecystitis and myocardial infarction: a case study with coronary involvement
Authors: Meelu Omar A. , Baber Usman , Theodoropoulos Kleanthis , Mennuni Marco G. , Kini Annapoorna S. , Sharma Samin K. 
Published: July 2016

Key Clinical MessagePossible links between inflammatory stimuli and atherothrombotic disease in the context of gallbladder pathology are not well understood. Our case demonstrates that clinical suspicion of cardiac disease after a diagnosis of acute cholecystitis should remain high in light of the dire consequences of a missed diagnosis.
Cobalt–Nitrogen Co‐doped Carbon Nanotube Cathode Catalyst for Alkaline Membrane Fuel Cells
Authors: Kruusenberg Ivar , Ramani Dilip , Ratso Sander , Joost Urmas , Saar Rando , Rauwel Protima , Kannan Arunachala M. , Tammeveski Kaido 
Published: July 2016

AbstractA highly active state‐of‐the‐art catalyst was synthesized by cobalt–nitrogen co‐doping of multi‐walled carbon nanotubes (Co/N/MWCNT) as non‐precious metal catalyst using cobalt chloride and dicyandiamide by high‐temperature treatment. A range of physicochemical characterization methods were used to observe the surface structure and composition of the synthesized electrocatalyst material. The kinetics of the oxygen reduction reaction (ORR) on this catalyst material was studied in 0.1 m KOH solution by using the rotating‐disk electrode method. The Co/N/MWCNT catalyst showed excellent electrocatalytic activity for ORR in alkaline media. In addition, the performance of the catalyst in a fuel cell was evaluated by fabricating membrane electrode assemblies employing a Tokuyama® anion exchange membrane (AEM), with hydrogen and oxygen gases at various temperatures. AEM fuel cell with Co/N/MWCNT cathode catalyst exhibited a power density of 115 mW cm−2 with H2/O2 gases (100 % RH) at ambient pressure at 50 °C.
Efficient Electrochemical Production of Syngas from CO2 and H2O by using a Nanostructured Ag/g‐C3N4 Catalyst
Authors: Sastre Francesc , Muñoz‐Batista Mario J. , Kubacka Anna , Fernández‐García Marcos , Smith Wilson A. , Kapteijn Freek , Makkee Michiel , Gascon Jorge 
Published: July 2016

AbstractA new series of electrocatalysts consisting of Ag nanoparticles supported on graphitic carbon nitride (g‐C3N4) are presented. The combination of nanostructured silver and a carbon nitride support results in the direct generation of synthesis gas (CO+H2) during the electrocatalytic reduction of CO2 in water. By using a state‐of‐the‐art electrocatalytic setup, the influence of different operation parameters over the final product composition is shown. The H2/CO product ratio can easily be tuned from 100:1 to 2:1 with high reproducibility by controlling the applied potential and the Ag loading. More importantly, long‐term and catalyst reuse experiments demonstrate the robustness of these electrodes, which could be operated for over 20 h time on stream and reused several times without any evident loss of activity or selectivity. Our results highlight the potential of nanostructuring Ag‐based catalysts and the relevance of the selected support for the green valorization of CO2.
Post‐synthetic Spin‐Labeling of RNA through Click Chemistry for PELDOR Measurements
Authors: Kerzhner Mark , Abdullin Dinar , Więcek Jennifer , Matsuoka Hideto , Hagelueken Gregor , Schiemann Olav , Famulok Michael 
Published: July 2016

AbstractSite‐directed spin labeling of RNA based on click chemistry is used in combination with pulsed electron‐electron double resonance (PELDOR) to benchmark a nitroxide spin label, called here dŲ. We compare this approach with another established method that employs the rigid spin label Çm for RNA labeling. By using CD spectroscopy, thermal denaturation measurements, CW‐EPR as well as PELDOR we analyzed and compared the influence of dŲ and Çm on a self‐complementary RNA duplex. Our results demonstrate that the conformational diversity of dŲ is significantly reduced near the freezing temperature of a phosphate buffer, resulting in strongly orientation‐selective PELDOR time traces of the dŲ‐labeled RNA duplex.
A Trimodal Closomer Drug‐Delivery System Tailored with Tracing and Targeting Capabilities
Authors: Sarma Saurav J. , Khan Aslam A. , Goswami Lalit N. , Jalisatgi Satish S. , Hawthorne M. Frederick 
Published: July 2016

AbstractThe construction and application of a unique monodisperse closomer drug‐delivery system (CDDS) integrating three different functionalities onto an icosahedral closo‐dodecaborane [B12]2− scaffold is described. Eleven B‐OH vertices of [closo‐B12(OH)12]2− were used to attach eleven copies of the anticancer drug chlorambucil and the targeting vector glucosamine through a bifurcating lysine linker. The remaining twelfth vertex was used to attach a fluorescent imaging probe. The presence of multiple glucosamine units offered a monodisperse and highly water‐soluble CDDS with a high payload of therapeutic cargo. This array enhanced the penetration of the drug into cancer cells by exploiting the overexpression of GLUT‐1 receptors present on cancer cells. About 15‐fold enhancement in cytotoxicity was observed for CDDS‐1 against Jurkat cells, compared to CDDS‐2, which lacks the GLUT‐1 targeting glucosamine. A cytotoxicity comparison of CDDS‐1 against colorectal RKO cells and its GLUT‐1 knock‐out version confirmed that GLUT‐1 mediates endocytosis. Using fluorescent markers both CDDS‐1 and ‐2 were traced to the mitochondria, a novel target for alkylating agents.
ChemInform Abstract: Facile Surfactant‐Free Synthesis of p‐Type SnSe Nanoplates with Exceptional Thermoelectric Power Factors.
Authors: Gregory Duncan H. , et al.  
Published: July 2016

AbstractSingle‐phase orthorhombic SnSe nanoplates are fabricated in gram quantities by boiling a black precipitate formed by combining aqueous solutions of NaHSe and Na2SnO2 (2 h, 94% yield).
ChemInform Abstract: Synthesis of a Self‐Assembling Gold Nanoparticle‐Supported Organocatalyst for Enamine‐Based Asymmetric Aldol Reactions.
Authors: Soti Peter Lajos , Yamashita Hiroki , Sato Kohei , Narumi Tetsuo , Toda Mitsuo , Watanabe Naoharu , Marosi Gyoergy , Mase Nobuyuki 
Published: July 2016

AbstractThe self‐assembling gold nanoparticle‐supported L‐proline derivative generated in four steps from 4‐hydroxy‐l‐proline and chloroauric acid, is used for enamine‐based aldol reactions.
ChemInform Abstract: Unprecedented Intramolecular [4 + 2]‐Cycloaddition Between a 1,3‐Diene and a Diazo Ester.
Authors: Qiu Huang , Srinivas Harathi D. , Zavalij Peter Y. , Doyle Michael P. 
Published: July 2016

AbstractThe first examples for [4+2] cycloaddition reactions of diazo compounds, normally prone to undergo [3+2] addition, are presented.
ChemInform Abstract: Enantioselective Alkylation of Amino Acid Derivatives Promoted by Cyclic Peptoids under Phase‐Transfer Conditions.
Authors: Schettini Rosaria , De Riccardis Francesco , Della Sala Giorgio , Izzo Irene 
Published: July 2016

AbstractA library of proline‐containing cyclopeptoids is prepared, characterized and their complexing ability is evaluated.
ChemInform Abstract: Ring Expansion via Cleavage of Benzylic C—C Bonds Enabling Direct Synthesis of Medium Ring‐Fused Benzocarbocycles.
Authors: Rao Bin , Tang Jinghua , Wei Yu , Zeng Xiaoming 
Published: July 2016

AbstractThe metal‐free title method is successfully applied to the preparation of 7‐ and 8‐membered rings, but fails upon attempts to synthesize 9‐ and 10‐membered rings.
ChemInform Abstract: Dicalcium Phosphate Dihydrate DCPD as a Highly Efficient and Reusable Catalyst for Knoevenagel Condensation.
Authors: Benzekri Zakaria , El Mejdoubi Khalid , Boukhris Said , Sallek Brahim , Lakhrissi Brahim , Souizi Abdelaziz 
Published: July 2016

AbstractCondensation reactions of various substituted benzaldehydes with active methylene compounds using DCPD as highly active heterogeneous catalyst under green reaction conditions are investigated.
ChemInform Abstract: Photoredox Mediated Nickel Catalyzed Cross‐Coupling of Thiols with Aryl and Heteroaryl Iodides via Thiyl Radicals.
Authors: Oderinde Martins S. , Frenette Mathieu , Robbins Daniel W. , Aquila Brian , Johannes Jeffrey W. 
Published: July 2016

AbstractHighly chemoselective photoinduced Ni‐catalyzed cross‐coupling reactions of aryl, benzyl, and alkyl thiols with aryl and heteroaryl iodides in the presence of an Ir(III)‐photoredox catalyst are developed.
ChemInform Abstract: Synergistic Rhodium/Copper Catalysis: Synthesis of 1,3‐Enynes and N‐Aryl Enaminones.
Authors: Wang Nan‐Nan , Huang Lei‐Rong , Hao Wen‐Juan , Zhang Tian‐Shu , Li Guigen , Tu Shu‐Jiang , Jiang Bo 
Published: July 2016

AbstractA variety of both types of the highly functionalized title compounds is available under Rh/Cu catalysis according to conditions A) or B) with an excellent stereoselectivity.
ChemInform Abstract: Synthesis of 1‐Naphthaldehydes via the Cascade Reactions of 1‐Phenylpent‐4‐yn‐2‐ols Promoted by Iodine Monochloride.
Authors: Li Bin , Shen Nana , Fan Xuesen , Zhang Xinying 
Published: July 2016

AbstractThe title compounds are prepared by a cascade reaction involving an intramolecular Friedel—Crafts reaction, dehydration, and oxidation in good yields and excellent regioselectivity.
ChemInform Abstract: Activated Alumina Balls under Neat Conditions: A Green Catalyst for the Synthesis of Spiro‐Heterocyclic Scaffolds by Ring‐Opening versus Annulation of the Isatin Moiety.
Authors: Mondal Animesh , Banerjee Biplab , Bhaumik Asim , Mukhopadhyay Chhanda 
Published: July 2016

AbstractThe spiro‐heterocycles are synthesized from a one‐pot reaction of amines, β‐keto esters, indanones and isatins using activated alumina balls (3‐5 mm diameter) as the catalyst.
ChemInform Abstract: Reagent‐Controlled Tandem Reactions of Vinyl Epoxides: Access to Functionalized γ‐Butenolides.
Authors: Ma Juan , Yuan Zhe‐zhe , Kong Xiang‐wen , Wang Huai , Li Yi‐ming , Xiao Hua , Zhao Gang 
Published: July 2016

AbstractEpoxides (I) are used for the title reactions with trifluoromethyl ketones or aldehydes in the presence of PBu3 to produce 3‐alkenyl γ‐butenolide synthons with excellent (E)‐selectivity.
ChemInform Abstract: Catalytic Cross‐Benzoin/Michael/Acetalization Cascade for Asymmetric Synthesis of Trifluoromethylated γ‐Butyrolactones.
Authors: He Xiang‐Hong , Yang Lei , Huang Wei , Zhao Qian , Pan Xiao‐Li , Jiang Dao‐Feng , Yang Ming‐Cheng , Peng Cheng , Han Bo 
Published: July 2016

AbstractThe title compounds are prepared by sequential NHC‐amine catalytic one‐pot cascade reaction of aromatic aldehydes, trifluoroacetaldehyde ethyl hemiacetal, and enals.
ChemInform Abstract: Synthesis of New 2,5‐Di(thiophen‐2‐yl)furan‐3‐carbonitrile Derivatives and Investigation of the Electrochromic Properties of Homopolymers and Co‐Polymers with EDOT.
Authors: Abaci Ufuk , Ustalar Asli , Yilmaz Mehmet , Guney H. Yuksel 
Published: July 2016

AbstractThe title carbonitriles are prepared by reaction of oxopropanenitriles with alkenes mediated by mangenese(III) acetate followed by oxidation with DDQ.
ChemInform Abstract: Synthesis of Indole‐Annulated Sulfur Heterocycles Using Copper‐Catalyzed C—N Coupling and Palladium‐Catalyzed Direct Arylation.
Authors: Shelke Ganesh M. , Jha Mukund , Kumar Anil 
Published: July 2016

AbstractBiologically relevant benzothiazinoindoles and isothiochromenoindoles are prepared using Cu‐catalyzed Ullmann‐type coupling and Pd‐catalyzed arylation, respectively, as key steps to construct the polycyclic frameworks.
ChemInform Abstract: Study and Application of Noncatalyzed Photoinduced Conjugation of Azides and Cycloocta‐1,2,3‐selenadiazoles.
Authors: Jedinakova P. , Sebej P. , Slanina T. , Klan P. , Hlavac J. 
Published: July 2016

Abstract1,2,3‐Triazoles are prepared by cycloaddition of azides with cyclooctyne in situ generated by photolysis of cyclooctaselenadiazole (I).
ChemInform Abstract: tert‐Butyl Hydroperoxide Mediated Cascade Synthesis of 3‐Arylsulfonylquinolines.
Authors: Zhang Liangliang , Chen Su , Gao Yuzhen , Zhang Pengbo , Wu Yile , Tang Guo , Zhao Yufen 
Published: July 2016

AbstractTreatment of aromatic amines bearing an N‐propargyl chain with 2 equiv.
ChemInform Abstract: Manganese(III) Acetate Mediated Oxidative Radical Cyclizations of α‐Substituted N‐[2‐(Phenylethynyl)phenyl]acetamides.
Authors: Chuang Che‐Ping , Chen Yan‐Jhu 
Published: July 2016

AbstractTwo effective methods for the synthesis of 3,4‐disubstituted quinolin‐2(1H)‐ones are reported.
ChemInform Abstract: Novel Multi‐Component Syntheses of Pyrimidines Using β‐CD in Aqueous Medium.
Authors: Rakhi Chowrasia , Ramesh Katla , Darbem Mariana P. , Branquinho Tabata A. , de Oliveira Aline Rufino , Manjari Padma Sunitha , Domingues Nelson Luis C. 
Published: July 2016

AbstractThe condensation reaction of 1,3‐diketones, aldehydes, and ammonium acetate proceeds in water in the presence of β‐cyclodextrine as catalyst to afford pyrimidine derivatives in good to excellent yields.
ChemInform Abstract: Multicomponent Reaction of Benzyl Halides: Synthesis of [1,2,4]Triazolo/benzimidazolo Quinazolinones.
Authors: Beerappa Mallappa , Shivashankar Kalegowda 
Published: July 2016

AbstractThe title compounds are prepared under environmentally friendly reaction conditions by a highly efficient one‐pot cascade sequence involving oxidation, Knoevenagel condensation, and Michael addition followed by cyclization and dehydration.
ChemInform Abstract: Synthesis of Imidazo[1,2‐a]quinoxalines by Double Groebke Reactions and Inhibitory Effects on Radicals and DNA Oxidation.
Authors: Chen Jia‐Feng , Liu Zai‐Qun 
Published: July 2016

AbstractThe starting 2‐aminoquinoxalines are prepared from o‐phenylenediamine, an aldehyde and tert‐octylisonitrile by a first Groebke three‐component reaction (not shown).
ChemInform Abstract: Catalytic and Enantioselective Synthesis of Chiral Multisubstituted Tribenzothiepins by Intermolecular Cycloadditions.
Authors: Tahara Yu‐ki , Matsubara Riku , Mitake Akihito , Sato Tatsuki , Kanyiva Kyalo Stephen , Shibata Takanori 
Published: July 2016

AbstractThe title compounds are prepared under mild reaction conditions by intermolecular cycloaddition of either diphenyl‐sulfide‐tethered diynes or 2‐phenyl sulfanylbenzene‐tethered diynes with a monoalkyne.
ChemInform Abstract: Synthesis of α‐Trifluoromethyl‐β‐keto Phosphonates by Electrophilic Trifluoromethylation with Togni Reagent.
Authors: Fu Wen‐Zhi , Huang Yangen , Xu Xiu‐Hua , Qing Feng‐Ling 
Published: July 2016

AbstractVarious title phosphonates are prepared starting from cyclic and acyclic β‐keto phosphonates.
ChemInform Abstract: Three Diketopiperazines from Marine‐Derived Bacteria Inhibit LPS‐Induced Endothelial Inflammatory Responses.
Authors: Kang Hyejin , Ku Sae‐Kwang , Choi Hyukjae , Bae Jong‐Sup 
Published: July 2016

AbstractThree diketopiperazines (Ia), (Ib), and (Ic) are isolated from two strains of marine‐derived bacteria.
ChemInform Abstract: Catalytic Asymmetric Total Synthesis of Hedyosumins A, B, and C.
Authors: Sun Wang‐Bin , Wang Xuan , Sun Bing‐Feng , Zou Jian‐Ping , Lin Guo‐Qiang 
Published: July 2016

AbstractThe first asymmetric total synthesis of Hedyosumins A, B, and C is accomplished in 13‐14 steps from simple starting materials.
ChemInform Abstract: seco‐Casbanes from the Australian Rainforest: ECD Predictions Key for Determining Remote Absolute Configuration.
Authors: Maslovskaya Lidia A. , Savchenko Andrei I. , Gordon Victoria A. , Reddell Paul W. , Pierce Carly J. , Parsons Peter G. , Williams Craig M. 
Published: July 2016

AbstractTwo novel seco‐casbanes EBC‐328 (I) and EBC‐363 (II) from the australian rainforest plant Croton insularis.
“Chemical Blowing” of Sausage‐Like Carbon Nanotubes with Oriented Graphene‐Layer Walls
Authors: Zhong Bo , Liu Defei , Yu Yuanlie 
Published: July 2016

AbstractSausage‐like carbon nanotubes (SLCNTs) have been fabricated via a facile thermal treatment of a homogeneous solution of ammonia borane/dimethylethanolamine with anodic alumina oxide as a template in the absence of metal catalysts. The walls of these SLCNTs contain layers of graphene oriented at an angle towards the tube axis, deviating from the general structure of multi‐walled carbon nanotubes in which all lattice walls are parallel along the longitudinal axis. The current versus voltage measurements perpendicular to the axis reveals that the SLCNTs possess a resistivity of ∼80 Ω m.
Consistent quantitative gene product expression: #1. Automated identification of regenerating bone marrow cell populations using support vector machines
Authors: Voigt Andrew P. , Eidenschink Brodersen Lisa , Pardo Laura , Meshinchi Soheil , Loken Michael R. 
Published: July 2016

AbstractIdentification and quantification of maturing hematopoietic cell populations in flow cytometry data sets is a complex and sometimes irreproducible step in data analysis. Supervised machine learning algorithms present promise to automatically classify cells into populations, reducing subjective bias in data analysis. We describe the use of support vector machines (SVMs), a supervised algorithm, to reproducibly identify two distinctly different populations of normal hematopoietic cells, mature lymphocytes and uncommitted progenitor cells, in the challenging setting of pediatric bone marrow specimens obtained 1 month after chemotherapy. Four‐color flow cytometry data were collected on a FACS Calibur for 77 randomly selected postchemotherapy pediatric patients enrolled on the Children's Oncology Group clinical trial AAML1031. These patients demonstrated no evidence of detectable residual disease and were divided into training (n = 27) and testing (n = 50) cohorts. SVMs were trained to identify mature lymphocytes and uncommitted progenitor cells in the training cohort before independent evaluation of prediction efficiency in the testing cohort. Both SVMs demonstrated high predictive performance (lymphocyte SVM: sensitivity >0.99, specificity >0.99; uncommitted progenitor cell SVM: sensitivity = 0.94, specificity >0.99) and closely mirrored manual cell classifications by two expert‐analysts. SVMs present an efficient, automated methodology for identifying normal cell populations even in stressed bone marrows, replicating the performance of an expert while reducing the intrinsic bias of gating procedures between multiple analysts. © 2016 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of ISAC.