bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expectation-induced modulation of metastable activity underlies faster coding of sensory stimuli
Authors: Mazzucato L. , La Camera G. , Fontanini A. , Alfredo Fontanini , Giancarlo La Camera 
Published: October 2017

AbstractSensory stimuli can be recognized more rapidly when they are expected. This phenomenon depends on expectation affecting the cortical processing of sensory information. However, virtually nothing is known on the mechanisms responsible for the effects of expectation on sensory networks. Here, we report a novel computational mechanism underlying the expectation-dependent acceleration of coding observed in the gustatory cortex (GC) of alert rats. We use a recurrent spiking network model with a clustered architecture capturing essential features of cortical activity, including the metastable activity observed in GC before and after gustatory stimulation. Relying both on network theory and computer simulations, we propose that expectation exerts its function by modulating the intrinsically generated dynamics preceding taste delivery. Our model, whose predictions are confirmed in the experimental data, demonstrates how the modulation of intrinsic metastable activity can shape sensory coding and mediate cognitive processes such as the expectation of relevant events. Altogether, these results provide a biologically plausible theory of expectation and ascribe a new functional role to intrinsically generated, metastable activity.
Linked dimensions of psychopathology and connectivity in functional brain networks
Authors: Xia Cedric Huchuan , Ma Zongming , Ciric Rastko , Gu Shi , Betzel Richard F. , Kaczkurkin Antonia N. , Calkins Monica E. , Cook Philip A. , la Garza Angel Garcia de , Vandekar Simon , Moore Tyler M. , Roalf David R. , Ruparel Kosha , Wolf Daniel H. , Davatzikos Christos , Gur Ruben C. , Gur Raquel E. , Shinohara Russell T. , Bassett Danielle S. , Satterthwaite Theodore D. 
Published: October 2017

ABSTRACTNeurobiological abnormalities associated with psychiatric disorders do not map well to existing diagnostic categories. High co-morbidity and overlapping symptom domains suggest dimensional circuit-level abnormalities that cut across clinical diagnoses. Here we sought to identify brain-based dimensions of psychopathology using multivariate sparse canonical correlation analysis (sCCA) in a sample of 663 youths imaged as part of the Philadelphia Neurodevelopmental Cohort. This analysis revealed highly correlated patterns of functional connectivity and psychiatric symptoms. We found that four dimensions of psychopathology — mood, psychosis, fear, and externalizing behavior — were highly associated (r=0.68-0.71) with distinct patterns of functional dysconnectivity. Loss of network segregation between the default mode network and executive networks (e.g. fronto-parietal and salience) emerged as a common feature across all dimensions. Connectivity patterns linked to mood and psychosis became more prominent with development, and significant sex differences were present for connectivity patterns related to mood and fear. Critically, findings replicated in an independent dataset (n=336). These results delineate connectivity-guided dimensions of psychopathology that cut across traditional diagnostic categories, which could serve as a foundation for developing network-based biomarkers in psychiatry.
Requirement of the Dynein-adaptor Spindly for mitotic and post-mitotic functions inDrosophila
Authors: Clemente Giuliana D. , Hannaford Matthew R. , Januschke Jens , Griffis Eric R. , Muller Hans-Arno J. 
Published: October 2017

AbstractSpindly is a mitotic checkpoint protein originally identified as a specific regulator of Dynein activity at the kinetochore. In metaphase, Spindly recruits the Dynein/Dynactin complex, promoting the establishment of stable kinetochore-microtubule interactions and progression into anaphase. While details of Spindly function in mitosis have been worked out in cultured human cells and in theC. eleganszygote, the function of Spindly within the context of an organism has not yet been addressed. Here we present loss- and gain-of-function studies of Spindly inDrosophila. We investigated the requirements of distinct protein domains for the localisation and function of Spindly. We find that knock-down of Spindly results in a range of mitotic defects in the female germ line and during cleavage divisions in embryogenesis. Overexpression of Spindly in the female germ line is embryonic lethal and results in altered egg morphology. To determine whether Spindly plays a role in post-mitotic cells we altered Spindly protein levels in migrating cells and found that ovarian border cell migration is sensitive to the levels of Spindly protein. Our study uncovers novel functions of the mitotic checkpoint protein Spindly inDrosophila.
Egg viability decreases rapidly with time since ovulation in the rainbow darter: implications for the costs of choosiness
Authors: Moran Rachel L. , Soukup Rachel M. , Zhou Muchu , Fuller Rebecca C. 
Published: October 2017

AbstractEgg viability in the rainbow darterEtheostoma caeruleum, a fish apparently lacking female mate choice, was found to decline rapidly after ovulation. We observed that the majority of a female’s clutch may fail to hatch if she is prevented from mating for as little as six hours. These data suggest that exercising female mate preferences may be selectively disfavoured inE. caeruleumdue to the high cost of delaying mating.
Clinical and genomic crosstalk between glucocorticoid receptor and estrogen receptor α in endometrial cancer
Authors: Vahrenkamp Jeffery M. , Yang Chieh-Hsiang , Rodriguez Adriana C. , Almomen Aliyah , Berrett Kristofer C. , Trujillo Alexis N. , Guillen Katrin P. , Welm Bryan E. , Jarboe Elke A. , Janat-Amsbury Margit M. , Gertz Jason 
Published: October 2017

SummarySteroid hormone receptors are simultaneously active in many tissues and are capable of altering each other’s function. Estrogen receptor α (ER) and glucocorticoid receptor (GR) are expressed in the uterus and their ligands have opposing effects on uterine growth. In endometrial tumors with high ER expression, we surprisingly found that expression of GR is associated with poor prognosis. Dexamethasone reduced normal uterine growthin vivo; however, this growth inhibition was abolished in estrogen-induced endometrial hyperplasia. We observed low genomic binding site overlap when ER and GR are induced with their respective ligands; however, upon simultaneous induction they co-occupy more sites. GR binding is significantly altered by estradiol with GR recruited to ER bound loci that become more accessible upon estradiol induction. Gene expression responses to co-treatment were more similar to estradiol, but with novel regulated genes. Our results suggest phenotypic and molecular interplay between ER and GR in endometrial cancer.
Electron microscopic evidence that Aip1 disintegrates cofilin-saturated F-actin domains in the presence of coronin
Authors: Tang Vivian W. , Nadkarni Ambika V. , Brieher William M. 
Published: October 2017

AbstractCofilin is an essential actin filament severing protein necessary for fast actin turnover dynamics. Segments of actin bound to cofilin adapt an alternative twist. This configuration is stable, but boundaries between cofilin occupied and unoccupied polymer are weak and fragment. Coronin and Aip1 are two factors that promote cofilin mediated actin filament disassembly, but whether they simply accelerate the basic cofilin severing mechanism or alter the mode of filament disassembly is still being investigated. Using electron microscopy and spectroscopy, we show that coronin accelerates phosphate release from F-actin to stimulate highly cooperative cofilin binding on to the polymer creating long stretches with a hypertwisted morphology. We find that Aip1 attacks these hypertwisted regions along their length, not just the boundaries, causing sections to disintegrate into monomers. Therefore, coronin promotes cofilin binding to F-actin to generate longer segments of polymer that are themselves the substrates for Aip1 mediated disintegration, as opposed to simply creating more heterotypic junctions that would sever. The morphological characteristics of the disassembling filaments along with spectroscopic data showing the rapid liberation of actin monomers suggest that the combination of cofilin, coronin, and Aip1 might be triggering a more catastrophic mode of filament disassembly than severing.
Attractor dynamics in networks with learning rules inferred fromin vivodata
Authors: Pereira Ulises , Brunel Nicolas 
Published: October 2017

AbstractThe attractor neural network scenario is a popular scenario for memory storage in association cortex, but there is still a large gap between models based on this scenario and experimental data. We study a recurrent network model in which both learning rules and distribution of stored patterns are inferred from distributions of visual responses for novel and familiar images in inferior temporal cortex (ITC). Unlike classical attractor neural network models, our model exhibits graded activity in retrieval states, with distributions of firing rates that are close to lognormal. Inferred learning rules are close to maximizing the number of stored patterns within a family of unsupervised Hebbian learning rules, suggesting learning rules in ITC are optimized to store a large number of attractor states. Finally, we show that there exists two types of retrieval states: one in which firing rates are constant in time, another in which firing rates fluctuate chaotically.
The cell cycle gene regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb
Authors: Iness Audra N. , Felthousen Jessica , Ananthapadmanabhan Varsha , Guiley Keelan Z. , Dozmorov Mikhail , Rubin Seth M. , Litovchick Larisa 
Published: October 2017

AbstractThe oncogeneMYBL2(encoding B-Myb) is a poor prognostic biomarker in many cancers. B-Myb interacts with the MuvB core of five proteins (LIN9, LIN37, LIN52, LIN53/RBBP4, and LIN54) to form the MMB (Myb-MuvB) complex and promotes expression of late cell cycle genes necessary for progression through mitosis. BothMYBL2amplification and over-expression are associated with deregulation of the cell cycle and increased cell proliferation. Alternatively, by interacting with E2F4-DP1 and p130 or p107, the MuvB core becomes part of the DREAM complex (DP, RB-like, E2F, and MuvB). The DREAM complex opposes MMB by globally repressing cell cycle genes in G0/G1, maintaining the cell in a quiescent state. However, the specific mechanism by which B-Myb alters the cell cycle is not well understood. Our analysis of The Cancer Genome Atlas data revealed significant upregulation of DREAM and MMB target genes in breast and ovarian cancer withMYBL2gain. Given that most of the DREAM target genes are not directly regulated by B-Myb, we investigated the effects of B-Myb on DREAM formation. We found that depletion of B-Myb results in increased DREAM formation in human cancer cells, while its overexpression inhibits DREAM formation in the non-transformed cells. Since the MuvB core subunit LIN52 is essential for assembly of both the DREAM and MMB complexes, we tested whether B-Myb disrupts DREAM by sequestering LIN52. Overexpression of LIN52 did not increase either DREAM or MMB formation, but instead increased the turnover rate of the endogenous LIN52 protein. Interestingly, co-expression of B-Myb increased the expression of both endogenous and overexpressed LIN52 while knockdown of B-Myb had an opposite effect. We found that regulation of LIN52 occurs at the protein level, and that activity of DYRK1A kinase, the enzyme that triggers DREAM complex formation by phosphorylating LIN52, is required for this regulation. These findings are the first to implicate B-Myb in the disassembly of the DREAM complex and offer insight into the underlying mechanisms of poor prognostic value ofMYBL2amplification in cancer. We conclude that B-Myb mediates its oncogenic effects not only by increasing mitotic gene expression by the MMB complex, but also by broad disruption of cell cycle gene regulatory programs through compromised DREAM formation.
Ontology-based similarity calculations with an improved annotation model
Authors: Köhler Sebastian 
Published: October 2017

AbstractA typical use case of ontologies is the calculation of similarity scores between items that are annotated with classes of the ontology. For example, in differential diagnostics and disease gene prioritisation, the Human Phenotype Ontology (HPO) is often used to compare a query phenotype profile against gold-standard phenotype profiles of diseases or genes. The latter have long been constructed as flat lists of ontology classes, which, as we show in this work, can be improved by exploiting existing structure and information in annotation datasets or full text disease descriptions.We derive a study-wise annotation model of diseases and genes and show that this can improve the performance of semantic similarity measures. Inferred weights of individual annotations are one reason for this improvement, but more importantly using the study-wise structure further boosts the results of the algorithms according to precision-recall analyses. We test the study-wise annotation model for diseases annotated with classes from the HPO and for genes annotated with Gene Ontology (GO) classes. We incorporate this annotation model into similarity algorithms and show how this leads to improved performance.This work adds weight to the need for enhancing simple list-based representations of disease or gene annotations. We show how study-wise annotations can be automatically derived from full text summaries of disease descriptions and from the annotation data provided by the GO Consortium and how semantic similarity measure can utilise this extended annotation model.
Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
Authors: Muñoz José F. , McEwen Juan G. , Clay Oliver K. , Cuomo Christina A. 
Published: October 2017

ABSTRACTDimorphic fungal pathogens cause a significant human disease burden and unlike most fungal pathogens affect immunocompetent hosts. To examine the origin of virulence of these fungal pathogens, we compared genomes of classic systemic, opportunistic, and non-pathogenic species, includingEmmonsiaand two basal branching, non-pathogenic species in the Ajellomycetaceae,Helicocarpus griseusandPolytolypa hystricis. We found that gene families related to plant degradation, secondary metabolites synthesis, and amino acid and lipid metabolism are retained inH. griseusandP. hystricis. While genes involved in the virulence of dimorphic pathogenic fungi are conserved in saprophytes, changes in the copy number of proteases, kinases and transcription factors in systemic dimorphic relative to non-dimorphic species may have aided the evolution of specialized gene regulatory programs to rapidly adapt to higher temperatures and new nutritional environments. Notably, both of the basal branching, non-pathogenic species appear homothallic, with both mating type locus idiomorphs fused at a single locus, whereas all related pathogenic species are heterothallic. These differences revealed that independent changes in nutrient acquisition capacity have occurred in the Onygenaceae and Ajellomycetaceae, and underlie how the dimorphic pathogens have adapted to the human host and decreased their capacity for growth in environmental niches.
Utilizing country image and well-known products for less-known products
Authors: Woo Hongjoo , Jin Byoungho , Ramkumar Bharath 
Published: October 2017

Purpose
Country image determines consumers’ beliefs toward the country’s products, through halo effect. While the relevant literature is predominantly focused on the context of well-known products from traditionally leading exporters, the purpose of this paper is to examine the two levels of halo effect (i.e. country image as halo and a well-known product category as halo) on a less-known product category from a recently developed country.

Design/methodology/approach
The purpose of study was carried out by using a quantitative approach. Survey responses were collected from 253 US consumers who are aged between 18 and 67 years. This study only examined South Korea and used the two selected product categories (i.e. cell phones and apparel) as samples for the study.

Findings
The results of a series of regression analyses confirmed that the positive images of South Korea and Korean cell phones served as halo, thereby enhancing the respondents’ beliefs toward Korean apparel, which is a less-known product category that they have not yet experienced. Further, the respondents’ positive beliefs toward both cell phones and apparel increased their purchase intentions of those two products.

Research limitations/implications
The findings of this study imply that the general country image and the country’s well-known product images are critical in introducing the country’s less-known product to foreign markets.

Originality/value
The originality of this study lies in its unique focus on relatively less-known product category of a recently developed country (i.e. Korean apparel), which received limited attention in the past research. This study is also one of the few attempts to examine the role of a country’s well-known products on the country’s less-known products, another level of halo effect in country image.
A consumer satisfaction model based on the integration of EDT and TAM
Authors: Cho Yunjin 
Published: October 2017

Purpose
The purpose of this paper is to examine the process of consumer satisfaction formation for e-commerce. The study also predicts that the satisfaction formation model of e-commerce will differ between the US and Korean consumers due to differences in cultural background.

Design/methodology/approach
The study integrates the expectation disconfirmation theory (EDT) and the technology acceptance model (TAM). The hypotheses are examined by analyzing a structural equation model for consumers in the USA and Korea.

Findings
The results show that the model demonstrates good fit for both groups. For consumers in both countries, when purchasing fashion products on a new e-commerce site, the performance of the site’s usefulness was found to be a crucial variable in their satisfaction and intention to use the site. While there was no significant difference in the multiple group measurement model invariance test, the findings are meaningful because the slight differences in the standard coefficients of the two groups are considered.

Originality/value
It is meaningful to apply EDT and the TAM to the daily deal site environment. The influence of related variables can be reconfirmed and new consumer behaviors can be better understood. The research provides fresh insights into consumer behavior that can benefit managers when they make decisions in the e-commerce field.
Nonlinear antecedents of customer satisfaction and loyalty in third-party logistics services (3PL)
Authors: Tontini Gerson , Söilen Klaus Solberg , Zanchett Ricardo 
Published: October 2017

PurposeThe purpose of this paper is to study the nonlinear impact of quality dimensions of third-party logistics (3PL) services on customer satisfaction and loyalty.Design/methodology/approachBy interviewing 167 small-size companies, and using penalty and reward contrast analysis, the paper explores the nonlinear impact of seven dimensions of 3PL services (safety, fault’s recovery, reliability, speed, flexibility, communication, and friendliness) on customer satisfaction and loyalty.FindingsThe results confirm the existence of the dimensions’ nonlinear impact on customer satisfaction. It also shows that some quality dimensions have a direct and nonlinear impact on loyalty. The dimension “friendliness” has a direct impact on loyalty if the company has a below market average performance, which may lead customers to switch service providers. “Flexibility on collection and delivery” has a direct impact if the company has a higher performance, contributing to customers’ intention to continue using the service. Another finding is that, if the company delivers good service recovery after the customer found faults in the service, and if customers trust the company service, they say they intend to continue to work with the company.Research limitations/implicationsThe present research focused only on small companies in one country (Brazil). Further studies should be carried out to explore different countries, with different realities, and different size of companies.Practical implications3PL companies should not only deal with customers’ satisfaction, but also with other quality aspects that directly affect customer intention to continue doing business with the 3PL service provider. These are friendliness, flexibility regarding time and frequency of collection and delivery and faults’ recovery.Originality/valueThe present research confirms that the personal relationship is a crucial aspect to be managed in order to keep customers in the long term. In addition, as opposed to most research looking for the antecedents of satisfaction and loyalty of 3PL customers, the present research shows that there is a direct nonlinear impact of the dimensions’ performance on customers’ loyalty, what should be taken in consideration by 3PL managers. It also shows how penalty-reward contrast analysis may reveal nonlinear antecedents that could be used for better understandings companies’ success in the long term.
Consumer perspectives on the ethics of an array of technology-based marketing strategies
Authors: Fullerton Sam , Brooksbank Roger , Neale Larry 
Published: October 2017

Purpose
Technology-based initiatives are now being routinely incorporated within most companies’ marketing strategies. The purpose of this paper is to explore consumer perspectives on the ethics of these initiatives. It also seeks to identify underlying dimensions within the technology-based strategic environment with the intent of generating advances for both academicians and practitioners alike.

Design/methodology/approach
The enquiry is based on a survey featuring a cross-section of 20 technology-based initiatives. A sample of 967 adult residents of the USA provided their views of the extent to which each initiative/scenario conformed to their perception of society’s norms regarding ethical acceptability.

Findings
In total, 13 of the 20 initiatives were deemed unacceptable with the greatest disdain exhibited for a company posting bogus online reviews. Most acceptable were self-service checkouts. Three sub-dimensions of the ethicality construct as it relates to technology-based marketing initiatives were identified and validated as measurement scales for use in future research: involvement, communication, and privacy.

Research limitations/implications
The generalization of findings may be limited because younger and older segments of the population were slightly under- and over-represented, respectively.

Practical implications
Marketers should recognize that consumers are much more accepting of any initiative from which they will derive some benefit. They should also recognize that within this arena, ethical acceptability is a multi-dimensional phenomenon, necessitating that they strategize accordingly.

Originality/value
Although previous research has garnered insights with respect to a particular technology-based marketing initiative, none have explored the relativities of consumer perceived ethicality across an array of different initiatives or examined any latent sub-dimensions of the construct in this arena. This study addresses these deficiencies.