bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estudio de factores asociados a la infertilidad masculina, su relación con la fragmentación del ADN y alteraciones en el espermograma de pacientes que acudieron a una clínica de fertilidad
Authors: Siavichay Gómez Lorena , Rosendo Chalma Pedro , González Cabrera Adriana Nohemí 
Published: September 2024

Introducción. La infertilidad es un problema de salud a nivel mundial y se define por la imposibilidad de lograr un embarazo después de 12 meses o más de relaciones sexuales regulares sin protección. Objetivo. Identificar y relacionar factores asociados a la infertilidad masculina con la integridad del ADN espermático y con los parámetros seminales de pacientes que asistieron a una clínica de fertilidad. Metodología: Este estudio es de tipo descriptivo no experimental, y comprendió 269 pacientes que fueron atendidos en el Centro de Reproducción Humana Biogepa de la ciudad de Cuenca durante enero del 2017 a diciembre del 2021. Se evaluó diferentes parámetros seminales y la integridad del ADN espermático mediante técnica de dispersión de cromatina (SCD). Resultados: Las ocupaciones de comerciante y oficinista fueron las más relevantes en los pacientes que participaron en el estudio. A su vez se identificó que los sujetos que reportaron no consumir ningún tipo de sustancia adictiva o recreativa se relacionaron a 15 grupos de alteraciones en el espermograma: uno con mono alteración, siete con di alteraciones, cuatro con tri alteraciones, uno con tetra alteración y dos con penta alteraciones. Además, los pacientes de todos los grupos etarios presentaron 3 mono alteraciones (Azoo, Hipo y Terato), una di alteración (Asteno- Terato), una tri alteración (Hipo-Asteno-Terato), y una penta alteración (Hipo-Oligo-Asteno-Necro- Terato). Por último, se relacionó los diferentes niveles de fragmentación de ADN espermático con los distintos grupos etarios y los diagnósticos obtenidos. Se observó que la di alteración (Asteno-Terato), se presenta en todos los grupos etarios, mostrando nivel de fragmentación de ADN buena y media. Conclusión: La calidad seminal pudiera estar asociada a diversos factores del entorno individual, lo que pudiera afectar a la infertilidad masculina. A su vez, la fragmentación del ADN espermático está relacionada con las alteraciones en el espermograma. Área de estudio genera Medicina. Área de estudio específica: Andrología. Tipo de estudio: Artículos originales.
On the influence of structural and chemical properties on the elastic modulus of woven bone under healing
Authors: Blázquez-Carmona Pablo , Mora-Macías Juan , Pajares Antonia , Mármol Álvaro , Reina-Romo Esther 
Published: October 2024

IntroductionWoven bone, a heterogeneous and temporary tissue in bone regeneration, is remodeled by osteoblastic and osteoclastic activity and shaped by mechanical stress to restore healthy tissue properties. Characterizing this tissue at different length scales is crucial for developing micromechanical models that optimize mechanical parameters, thereby controlling regeneration and preventing non-unions.MethodsThis study examines the temporal evolution of the mechanical properties of bone distraction callus using nanoindentation, ash analysis, micro-CT for trabecular microarchitecture, and Raman spectroscopy for mineral quality. It also establishes single- and two-parameter power laws based on experimental data to predict tissue-level and bulk mechanical properties.ResultsAt the macro-scale, the tissue exhibited a considerable increase in bone fraction, controlled by the widening of trabeculae. The Raman mineral-to-matrix ratios increased to cortical levels during regeneration, but the local elastic modulus remained lower. During healing, the tissue underwent changes in ash fraction and in the percentages of Calcium and Phosphorus. Six statistically significant power laws were identified based on the ash fraction, bone fraction, and chemical and Raman parameters.DiscussionThe microarchitecture of woven bone plays a more significant role than its chemical composition in determining the apparent elastic modulus of the tissue. Raman parameters were demonstrated to provide more significant power laws correlations with the micro-scale elastic modulus than mineral content from ash analysis.
The effect of blood flow-restrictive resistance training on the risk of atherosclerotic cardiovascular disease in middle-aged patients with type 2 diabetes: a randomized controlled trial
Authors: Ma Xiaojun , Lin Xuandong , Zhou Lei , Li Wen , Yi Qinyu , Lei Fulian , Tang Xuan , Ai Yuxin , Zhan Yating , Luo Huanyan , Wang Liduo , Lei Fenfang , He Binghua , Yang Fan , Ruan Sijie 
Published: October 2024

IntroductionThe aim of this study was to investigate the effects of blood flow-restrictive resistance training (BFR-RT) on improving metabolic abnormalities, blood pressure (BP), obesity, and 10-year atherosclerotic cardiovascular disease (ASCVD) risk in middle-aged patients with type 2 diabetes mellitus (T2DM).MethodWe conducted a parallel-group, single blind randomized controlled trial. Participants who met the inclusion criteria were randomly divided into control group, BFR-RT group and aerobic exercise (AE) group. Control group received health education and follow-up; Two exercise groups received supervised collective training for a period of six months, three times per week. AE group trained at moderate-intensity for 60 minutes each time, while BFR-RT group trained at low-intensity for 40 minutes each time. The primary outcomes were change in 10-year ASCVD risk index and level, and the secondary outcomes included changes in fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), blood lipids, BP, and obesity level within and across the three groups at baseline, the third and sixth months of intervention.ResultAmong 93 individuals (control group, n=31; AE, n=30; BFR-RT, n=32) were analyzed. At baseline, there were no significant differences in various indicators among the three groups (p&gt;0.05). After intervention, the 10-year ASCVD risk index and risk level of both exercise groups significantly decreased compared to the control group and baseline (p&lt;0.05), and the risk reduction became more pronounced over time. In the sixth month of intervention, the 10-year ASCVD risk index in the AE group decreased by 27.40%, and that in the BFR-RT group decreased by 26.78%. Meanwhile, apart from lipoprotein (a) and diastolic blood pressure, both exercise groups showed significant improvements in FPG, HbA1c, dyslipidemia, systolic blood pressure, and obesity indicators compared to the control group and baseline (p&lt;0.05). There was no significant difference in various indicators between the two exercise groups (p&gt;0.05).ConclusionBFR-RT could reduce the 10-year ASCVD risk in middle-aged T2DM patients for by improving metabolic abnormalities, BP and obesity, and its effect was similar to that of moderate-intensity AE.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?proj=178886, identifier ChiCTR2300074357.
KS18, a Mcl-1 inhibitor, improves the effectiveness of bortezomib and overcomes resistance in refractory multiple myeloma by triggering intrinsic apoptosis
Authors: Al-Odat Omar S. , Elbezanti Weam Othman , Gowda Krishne , Srivastava Sandeep K. , Amin Shantu G. , Jonnalagadda Subash C. , Budak-Alpdogan Tulin , Pandey Manoj K. 
Published: October 2024

Despite a record number of clinical studies investigating various anti-myeloma treatments, the 5-year survival rate for multiple myeloma (MM) patients in the US is only 55%, and almost all patients relapse. Poor patient outcomes demonstrate that myeloma cells are “born to survive” which means they can adapt and evolve following treatment. Thus, new therapeutic approaches to combat survival mechanisms and target treatment resistance are required. Importantly, Mcl-1, anti-apoptotic protein, is required for the development of MM and treatment resistance. This study looks at the possibility of KS18, a selective Mcl-1 inhibitor, to treat MM and overcome resistance. Our investigation demonstrates that KS18 effectively induces cell death in MM by dual regulatory mechanisms targeting the Mcl-1 protein at both transcriptional and post-translational levels. Specifically, KS18 suppresses Mcl-1 activation via STAT-3 pathway and promotes Mcl-1 phosphorylation/ubiquitination/proteasome-dependent protein degradation (UPS). Significantly, KS18 triggered caspase-dependent apoptosis in MM patient samples and bortezomib-resistant cells, synergizing with venetoclax to boost apoptosis. KS18 promises to overcome bortezomib and venetoclax resistance and re-sensitize myeloma cells to chemotherapy. Furthermore, the study shows the tremendous impact of KS18 in inhibiting colony formation in bortezomib-resistant cells and demonstrates significant tumor shrinkage in KS18-treated NSG mice without notable toxicity signs after 4 weeks of therapy with a single acceptable dose each week, indicating its powerful anti-neoplastic and anti-resistance characteristics. This study strongly implies that KS18 may treat MM and provide new hope to patients who are experiencing recurrence or resistance.
Precision Epidemiology: A Computational Analysis of the Impact of Algorithmic Prediction on the Relationship Between Population Epidemiology and Clinical Epidemiology
Authors: Esposito Elena , Angelini Paola , Schneider Sebastian 
Published: October 2024

ObjectivesPrecision Medicine (PM) uses advanced Machine Learning (ML) techniques and big data to develop personalized treatments, but healthcare still relies on traditional statistical procedures not targeted on individuals. This study investigates the impact of ML on epidemiology.MethodsA quantitative analysis of the articles in PubMed for the years 2000–2019 was conducted to investigate the use of statistical methods and ML in epidemiology. Using structural topic modelling, two groups of topics were identified and analysed over time: topics closer to the clinical side of epidemiology and topics closer to the population side.ResultsThe curve of the prevalence of topics associated with population epidemiology basically corresponds to the curve of the relative statistical methods, while the more dynamic curve of clinical epidemiology broadly reproduces the trend of algorithmic methods.ConclusionThe findings suggest that a renewed separation between clinical epidemiology and population epidemiology is emerging, with clinical epidemiology taking more advantage of recent developments in algorithmic techniques and moving closer to bioinformatics, whereas population epidemiology seems to be slower in this innovation.
Eco-Design of Thermopressing through Induction of 100% Coriander-Based Fiberboards: Optimization of Molding Conditions
Authors: Guaygua-Amaguaña Priscila , Vaca-Medina Guadalupe , Vialle Claire , Sablayrolles Caroline , Evon Philippe 
Published: October 2024

The hot pressing process for 100% coriander-based fiberboards was optimized using an induction RocTool system, which offers rapid mold heating and cooling. The fiberboards were made using deoiled press cake as a protein binder and extrusion-refined straw as reinforcement. Doehlert’s experimental design was used to evaluate the influence of pressure (10–50 MPa), molding time (60–300 s), and mold temperature (155–205 °C) on fiberboard properties, energy consumption, cost, and environmental impact. The results showed that the RocTool device allows for better temperature control during shaping throughout the mold, resulting in mechanical properties that are both more homogeneous across the entire surface of the panel and, more importantly, substantially improved. Using the isoresponse curves, the optimal hot pressing conditions were 35 MPa, 300 s, and 205 °C, corresponding to a 40.6 MPa flexural strength. However, it was observed that to achieve an MDF-like fiberboard with minimal production costs, much less restrictive molding conditions were sufficient, i.e., 32.5 MPa, 170 s, and 160 °C. The study revealed that maximum thermopressing conditions emitted 3.87 kg of CO2 eq., while conditions leading to the MDF-like board reduced emissions to 1.45 kg CO2 eq., resulting in a more environmentally friendly material.
The biological activities and phytochemical investigations of acacia Senegal's aqueous extracts of gum Arabic
Authors: Safia Khirani , Amina Bougoffa , Houda Tamma , Hamdi Imane 
Published: September 2024

This study aimed to ascertain the antibacterial, antioxidant, and anti-inflammatory properties of gum Arabic aqueous extracts from Acacia Senegal. Furthermore, the phytochemical research on these extracts investigated the metabolically active ingredients in gum Arabic. The antimicrobial activity of extracts was determined by diffusion of the disks .2,2 diphenyl-1-picrylhydrazyl free radical scavenging capacity was used to detect antioxidant activity. Then, the anti‑inflammatory activity of gum Arabic using albumin denaturation activity. Qualitative phytochemical analysis showed the presence of saponins, flavonoids, tannins, and alkaloids in the absence of anthocyans. The results of antioxidant activity by trapping the free radical DPPH obtained show that the extract of gum arabic reveals an interesting activity with a IC50 value of 62,40 ±0.21 mg/ml. Concerning the antibacterial activity, good inhibition was observed against Escherichia coli and Pseudomonas aeruginosa. The results indicated that gum arabic showed higher anti-inflammatory activity by inhibiting albumin denaturation at 75 mg/ml by 88.4%. The research outcomes demonstrate that Acacia Senegal gum can be useful for alternative treatments.
Métodos não farmacológicos e avaliação da dor neonatal: uma revisão narrativa
Authors: Fortes Amanda Karoliny Meneses Resende , Ferreira Ravena de Sousa Alencar , Miranda Érika Maria Marques Bacelar , Carvalho Adriana Quaresma de Souza , Oliveira Cristiana Pacífico , Sampaio Larissa da Silva , Muniz Ravenna Kelly Brito , Macedo Natália Rodrigues 
Published: September 2024

Objetivo: Conhecer na literatura os tipos de métodos não farmacológicos e de avaliação da dor para o recém-nascido em Unidade de Terapia Intensiva Neonatal. Metodologia: Trata-se de uma revisão narrativa da literatura, a busca foi realizada nos meses de março e abril de 2021, na Biblioteca Virtual de Saúde (BVS), usando os seguintes descritores: "Recém-Nascidos", “Manejo da Dor", “Unidades de Terapia Intensiva Neonatal". Após a aplicação dos critérios de inclusão e exclusão foram selecionados 10 artigos. Resultados: os estudos foram divididos em duas categorias temáticas: “Procedimentos dolorosos e avaliação da dor neonatal”, no qual abordou os inúmeros procedimentos dolorosos e a lacuna de escalas padronizadas para avaliação da dor; “Uso de técnicas não farmacológicas para o alivio da dor”, onde foram utilizadas inúmeras técnicas como o método canguru, no entanto ainda há a necessidade de ampliar esse uso. Considerações Finais: A maioria dos estudos destacou que existe falta de protocolos institucionais, capacitação do profissional e conscientização sobre a importância de tais intervenções na saúde do recém-nascido.
Descrição anatomotopográfica da vascularização hepática em carnívoros domésticos
Authors: Carvalho Tatiana Cruz Siqueira de , Godinho Ana Bárbara Freitas Rodrigues , Paula Anne Mota , Menezes Ramayana Ortiz de Sá , Modesto Laís Botelho , Souza Gustavo Silva de , Silveira Gabriela Esteves da , Gomes Anna Luiza Barreto , Silva Bruna de Abreu , Castro Lucas de Mello 
Published: September 2024

O fígado é a maior glândula do corpo dos animais e corresponde de 2 a 5% do peso corporal do indivíduo. Uma glândula que possui função exócrina, pela produção de bile, e endócrina, pela produção de albumina, fibrinogênio, α e β-globulinas, lipoproteínas, colesterol, IGF-1, angiotensinogênio, trombopoietina, betatrofina e hepcidina, sendo, também, responsável por importantes funções bioquímicas e sistêmicas para o metabolismo animal. O conhecimento anatomotopográfico da vascularização extra e intra-hepática é fundamental para intervenções cirúrgicas nesta víscera. Para o estudo, foi escolhida a angiotécnica, com perfusão e corrosão, e os vasos alvos foram a veia porta hepática e a artéria hepática. O material utilizado para repleção nos vasos foi o látex, corado de vermelho, para a artéria hepática, e de azul, para a veia porta hepática. O processo de corrosão do parênquima da vísceral se deu através do cozimento. Os modelos obtidos foram fotodocumentados e tiveram suas arquiteturas vasculares descritas. O calibre das principais ramificações foram mensurados e os dados organizados em tabelas para comparação. A avaliação anatomotopográfica comparativa entre os modelos obtidos dos carnívoros domésticos avaliados evidenciou diferença morfológica na vascularização entre o lado esquerdo e direito hepático. Em cães, ambos os vasos se ramificam e irrigam todos os lobos hepáticos, diferentemente dos felinos, onde a artéria hepática não se ramifica para o lobo hepático direito e caudado, sendo o lobo direito irrigado, exclusivamente, pela circulação portal. Ambas as espécies possuem a irrigação do lobo esquerdo pela circulação portal em razão aos ramos mais calibrosos da artéria hepática.
Phytochemical Analysis and Antioxidant Activity of Wormwood (Artemisia absinthium L.) as a Comparative Study Between in vitro and in vivo Plants
Authors: Ismael Zana Ibrahim , Toma Rafail Shlemon , Faizy Hadar Saeed 
Published: September 2024

Artemisia absinthium is a wild edible species presence in Iraqi Kurdistan region the local people has used the plants as a part of their traditional medicine and their daily life. Nowadays, these plants become more attractive and interested due to their phytochemicals and antioxidant activities. Therefore, This study sought to evaluate various phytochemicals of this plant's aerial section generated by micropropagation in-vitro at tissue culture Laboratory of College of Agricultural Engineering science/University of Duhok, and with identical plants harvested from the field from Gali Ali Bak (invivo), including the difference in total phenolic compound and flavonoid content and antioxidant activity using DPPH test. The results showed that A. absinthium plants were rich with the high concentration of phenolic components in the Invivo plant extract was high (1.65 mg gallic acid equivalents/g of dry extract, eq.100g-1), while it was lowest in the in-vitro plant extract (0.56 mg gallic acid). and (5.2 and 2.9 g of quercetin equivalents/g of dry extract, eq.100g-1 ) for the Invivo and in-vitro plants, respectively, were the determined amounts of flavonoids extracted in the Invivo plant extract compared to the in-vitro plant extract. The anti-oxidative activity was tested by measuring their ability to scavenge stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, the results displayed that the different quantities of plant extract of Invivo and in-vitro ranged between (150-300 g/ml) concentrations had radical-scavenging activity as comparative with the positive control (ascorbic acid),however the best value was at 200 g/ml for Invivo(118) as compared with positive control (ascorbic acid) (80.8). Thus, the evidence of this study shown that Artemisia can enhance natural medicines for human being.
Effect of milk thistle oil (Silymarin) on histopathological characteristics of local hens exposed to aflatoxins
Authors: Alabbody Huda Hameed K. 
Published: September 2024

The study aimed to assess Milk Thistle oi reducing the aflatoxin damage and improve the health status of local breed hens. The study was performed on 60 hens aged 35 weeks, weighing 2-2.5 kg of the body was obtained and housed on a private poultry farm in north of Baghdad (Altaji) for a period of 9 weeks from 22 October until 22 December 2020. Hens were divided to three treatments (20 hens). The first was fed a basal diet free of aflatoxin. The 2nd fed on a contaminated diet with aflatoxin (14.6 ppb) while the 3rd fed as in the 2nd with 0.5% of Milk Thistle oil /kg feed. A 5 hens from each group were slaughtered at the end of the trial for the histopathological inspection of liver, spleen and intestine tissues to evaluate the harmful effect of aflatoxin and the repairing role of Milk Thistle. In G2 Aflatoxin group there was leg weakness, lameness, abnormal pigmentation (shank, feet), lethargy, and the crop is free from food. While in the 3rd group, the macro and microscopic examination of the symptoms were less marked and almost invisible. We conclude that silymarin may have a highly effect in repairing the aflatoxin damage to the body tissues of laying hens.
Analisis Kesalahan Peserta Didik Dalam Menyelesaikan Soal Matematika Berdasarkan Kriteria Watson
Authors: Nisah Hairun - , Saragih Eva Margaretha , Mardhiyah Mardhiyah , Hutagaul Ferry , Nazla Nazla 
Published: September 2024

AbstractBased on the problems of students who frequently make mistakes when solving mathematical problems, especially when it comes to building materials of curved side spaces, this study will identify the series of errors that cause students to make errors when resolving the mathematics of building curved sides spaces. The study involved 28 students in the th grade. A qualitative descriptive approach is used in this study. The results of the descriptive research showed that students answered both questions at the reading stages correctly (with a percentage of 0% on each question), as well as the level of understanding and transformation (with percentages of 9.52%, and 4.76%, respectively, on questions No. 1 and 2), the process skill level, which has a percent of 14.28% and 19.04%, and the final step, that is, the coding of the final answer, which contributes to 19,04% of both questions. The findings of the study led to the conclusion that, according to Newman's approach, the most common errors occurred at the process skill stage and Endcoding Errors (19.04%).Keywords: Error analysis, watson criteria, problem solving, curved side room, students.AbstrakBerdasarkan masalah peserta didik yang kerap kali melakukan kesalahan ketika menyelesaikan masalah matematika, utamanya ketika menyangkut materi bangun ruang sisi lengkung, studi ini akan mengidentifikasi ragam kesalahan yang menyebabkan para peserta didik melakukan kekeliruan ketika memecahkan masalah matematika bangunan ruang sisi lengkung. Penelitian ini melibatkan 28 siswa kelas . Pendekatan deskriptif kualitatif digunakan dalam studi ini. Dari hasil penelitian yang bersifat deskriptif menunjukkan bahwa peserta didik menjawab kedua soal pada tahap membaca dengan benar (dengan persentase 0% pada setiap pertanyaan), serta tahap pemahaman dan transformasi (dengan persentase masing-masing 9,52% dan 4,76%, pada pertanyaan no. 1 dan 2), Tahap keterampilan proses, yang memiliki persentase 14,28% dan 19,04%, dan langkah terakhir, yaitu pengkodean respons akhir, yang menyumbang 19,04% dari kedua pertanyaan. Temuan penelitian mengarah pada kesimpulan bahwa, menurut pendekatan Newman, kesalahan yang paling sering terjadi yaitu pada tahap keterampilan proses dan Kesalahan Endcoding (19,04%).Kata kunci: Analisis kesalahan, kriteria watson, pemecahan masalah, bangun ruang sisi lengkung, siswa.