bluuebunny/crossref_metadata_2025_split huggingface dataset:
KPC: an important mechanism of resistance in K. pneumoniae isolates from intensive care units in the Midwest region of Brazil
Authors: Conci Campos Caroline , Franco Roriz Náthalia , Nogueira Espínola Camila , Aguilar Lopes Fernando , Tieppo Caroline , Freitas Tetila Andyane , Volpe Chaves Claudia Elizabeth , Alexandrino de Oliveira Priscilla , Rodrigues Chang Marilene 
Published: September 2017

Introduction: Infections caused by multidrug-resistant Klebsiella pneumoniae are difficult to treat and pose a serious threat to public health worldwide. Here, we describe the presence of carbapenemase-producing K. pneumoniae in intensive care units (ICU) of three major Mato Grosso do Sul hospitals located in the Midwest region of Brazil.
Methodology: A total of 165 K. pneumoniae isolates with reduced susceptibility to carbapenems as identified by the VITEK-2 compact system were studied. Antimicrobial susceptibility testing was performed using the disk diffusion method, as recommended by the Clinical and Laboratory Standards Institute, and the E-test method. The detection of carbapenemase was performed using the modified Hodge test and polymerase chain reaction.
Results: The blaKPC gene was identified in 88.1% (n=89) of the selected K. pneumoniae isolates from Beneficent Association of Campo Grande, 94.9% (n=34) of the isolates from the Regional Hospital of Mato Grosso do Sul and 95.2% (n=26) of the isolates from Maria Aparecida Pedrossian University Hospital. Resistance greater than 80% was observed against cephalosporins, aztreonam, ciprofloxacin and piperacillin/tazobactam. Carbapenemase-producing K. pneumoniae (Kp-KPC) isolates were considered important causative agents of urinary tract infections, pneumonia and bloodstream infections in ICU patients. While rarely reported in the literature, we documented three cases of meningoencephalitis caused by Kp-KPC.
Conclusions: Our study documents the presence of Kp-KPC in three major Mato Grosso do Sul state hospitals, providing key national epidemiology data. This is an important mechanism of resistance in K. pneumoniae isolates from ICU patients and is associated with resistance to multiple classes of antimicrobial drugs.
Molecular characterization of three enteroviral strains isolated in Kuwait from young children with serious conditions
Authors: Chehadeh Wassim , Ali Sanaa Abdulkader Moalim , Maimoona Syeda Mubeen 
Published: September 2017

Introduction: Human enteroviruses are single stranded RNA viruses associated with many serious diseases such as encephalitis and myocarditis. They consist of up to 100 immunologically and genetically distinct types. Three enteroviral isolates, 2104, 3936 and 3988, were previously isolated from patients with neurological disorders or sepsis-like illness. In this study, the molecular characterization of the three isolates was investigated.
Methodology: A full genome sequencing was performed by Sanger method, followed by phylogenetic and bootscanning analyses. A detailed analysis of genetic differences between the clinical and prototype isolates were investigated by mapping polymorphisms at nucleotide and amino acid levels, and by comparing RNA secondary structure in the noncoding regions.
Results: Based on the phylogenetic analysis of the VP1 gene and complete genome, 2104 was typed as coxsackievirus B1, 3936 as coxsackievirus B5, and 3988 as echovirus 7. Similarity and bootscan plots provided support for intra- and intertypic recombination crossover points occurring mainly along the nonstructural coding regions of the isolates. A sequence divergence of 12 to 14% was detected in the 5’-noncoding region between the clinical isolates and their corresponding prototype strains. Synonymous and nonsynonymous substitutions could be also mapped to different coding regions of the isolates, including those coding for the Puff, Knob and the hydrophobic pocket of the capsid. Examination of relative frequencies of synonymous and nonsynonymous substitutions in different coding regions of enteroviral isolates showed no evidence for selective pressure.
Conclusion: The results provided a better understanding of the genetic variations, evolution and adaptation of enteroviruses in Kuwait.
Use of Simulation to Integrate Cultural Humility Into Advanced Health Assessment for Nurse Practitioner Students
Authors: Ndiwane Abraham N. , Baker Nancy C. , Makosky Antonia , Reidy Patricia , Guarino Anthony J. 
Published: September 2017

Background:Increasing cultural humility among nursing students requires the application of knowledge and skills. The integration of an Objective Structured Clinical Examination (OSCE) offered nurse practitioner students practice in simulation.Method:This learning activity included pre- and postassessments of knowledge regarding cultural issues and level of student satisfaction. Course content included an exemplar video and a simulation interview with an African American standardized patient.Results:Of the 65 students enrolled, 97% completed OSCE interviews and 81% completed pre- and postsurveys. A 2-domain 3 × 2-time within-subjects ANOVA indicated a statistically significant interaction effect, reinforced by descriptive statistics. Follow-up pairedttests detected a significantly large knowledge increase. Standardized patient scenarios scored highest for satisfaction, followed by critical thinking, and with self-confidence scoring lowest.Conclusion:The favorable knowledge outcomes from this teaching intervention support future applications of OSCE methodology for teaching sensitive cross-cultural content. [J Nurs Educ.2017;56(9):567–571.]
An Evasive Manoeuvre, Automatically Controlled to Avoid the One of a Group of Many Obstacles Moving in a Vicinity of Flying Airplane
Authors: Graffstein Jerzy 
Published: September 2017

Abstract
Detection of a collision threat and an appropriate decision on passing by an obstacle are necessary for solving the problem of collision avoidance in case of aircraft motion within the airspace. In the article a method for detecting a threat of collision with the obstacle is presented for the case of many moving objects appearing within the neighbourhood of the aircraft. The analysis of an algorithm for making a preliminary decision on avoiding a collision with more than one moving obstacle was carried out. The shape of a class of evasive trajectories was proposed, and its reliability was proved. Numerical simulations of flight were completed for the considered type of aircraft in aforementioned conditions. The scope of these simulations covered all phases of obstacle avoiding manoeuvre, including a return to a straight-line part of flight trajectory pre-planned before the start.
Metzler Cyclic Electric Systems
Authors: Mitkowski Wojciech 
Published: September 2017

Abstract
In applications we meet with positive (nonnegative) systems. A system generated by a linear differential equation with a Metzler-matrix is called a nonnegative system. The paper shows the basic dynamic properties of nonnegative continuous-time systems. Considered was the example of an oscillating electrical circuit with a cyclic Metzler-matrix, enabling the correct physical interpretations.
Intervenção fisioterapêutica com suporte parcial de peso em indivíduos pós-ave: revisão sistemática
Authors: Garção Diogo Costa , Sobral Juliana Martins , Santos Júlio Cezar Dantas , Mendonça Vanessa Brenha Duailibe , Rezende Lucas Silva , Santana Mylena Maria Salgueiro , Fontes Patrícia Almeida , Oliveira Tássia Virginia de Carvalho 
Published: September 2017

Objetivo: Revisar sistematicamente a eficácia do suporte parcial de peso no paciente hemiparético após Acidente Vascular Encefálico. Material e Métodos: Realizou-se levantamento de bibliografia nas bases de dados PubMed, Scielo, Science Direct e Bireme, publicadas a partir de 1998 até 2010, no qual os onze itens descritos na Escala PEDro foram utilizados como critérios de classificação dos artigos. Essa pesquisa foi realizada em maio e perdurou até setembro de 2010. Resultados: Houve evidência significativa na melhora da resistência, do equilíbrio, da evolução, da habilidade e da velocidade da marcha dos pacientes hemiparéticos pós-AVE subagudo e crônico. Conclusão: A utilização dos programas de treino de marcha com o suporte parcial de peso corporal mostrou-se eficaz em boa parte dos artigos avaliados.
An Integrated Multi-Echelon Supply Chain Network Design Considering Stochastic Demand: A Genetic Algorithm Based Solution
Authors: Nakhjirkan Sara , Mokhatab Rafiei Farimah 
Published: September 2017

The growing trend of natural resources consumption has caused irreparable losses to the environment. The scientists believe that if environmental degradation continues at its current pace, the prospect of human life will be shrouded in mystery. One of the most effective ways to deal with the environmental adverse effects is by implementing green supply chains. In this study a multilevel mathematical model including supply, production, distribution and customer levels has been presented for routing–location–inventoryin green supply chain. Vehicle routing between distribution centres and customers has been considered in the model. Establishment place of distribution centres among potential places is determined by the model. The distributors use continuous review policy (r, Q) to control the inventory. The proposed model object is to find an optimal supply chain with minimum costs. To validate the proposed model and measure its compliance with real world problems, GAMS IDE/Cplex has been used. In order to measure the efficiency of the proposed model in large scale problems, a genetic algorithm has been used. The results confirm the efficiency of the proposed model as a practical tool for decision makers to solve location-inventory-routing problems in green supply chain. The proposed GA could reduce the solving time by 85% while reaching on the average 97% of optimal solution compared with exact method.
Driving Rhythm Method for Driving Comfort Analysis on Rural Highways
Authors: Yu Bo , Chen Yuren 
Published: September 2017

Driving comfort is of great significance for rural highways, since the variation characteristics of driving speed are comparatively complex on rural highways. Earlier studies about driving comfort were usually based on the actual geometric road alignments and automobiles, without considering the driver’s visual perception. However, some scholars have shown that there is a discrepancy between actual and perceived geometric alignments, especially on rural highways. Moreover, few studies focus on rural highways. Therefore, in this paper the driver’s visual lane model was established based on the Catmull-Rom spline, in order to describe the driver’s visual perception of rural highways. The real vehicle experiment was conducted on 100 km rural highways in Tibet. The driving rhythm was presented to signify the information during the driving process. Shape parameters of the driver’s visual lane model were chosen as input variables to predict the driving rhythm by BP neural network. Wavelet transform was used to explore which part of the driving rhythm is related to the driving comfort. Then the probabilities of good, fair and bad driving comfort can be calculated by wavelets of the driving rhythm. This work not only provides a new perspective into driving comfort analysis and quantifies the driver’s visual perception, but also pays attention to the unique characteristics of rural highways.
Traffic Speed Prediction for Highway Operations Based on a Symbolic Regression Algorithm
Authors: Linchao Li , Fratrović Tomislav , Jian Zhang , Bin Ran 
Published: September 2017

Due to the increase of congestion on highways, providing real-time information about the traffic state has become a crucial issue. Hence, it is the aim of this research to build an accurate traffic speed prediction model using symbolic regression to generate significant information for travellers. It is built based on genetic programming using Pareto front technique. With real world data from microwave sensor, the performance of the proposed model is compared with two other widely used models. The results indicate that the symbolic regression is the most accurate among these models. Especially, after an incident occurs, the performance of the proposed model is still the best which means it is robust and suitable to predict traffic state of highway under different conditions.
Isotopic Ratios of Tropical Methane Emissions by Atmospheric Measurement
Authors: Brownlow R. , Lowry D. , Fisher R. E. , France J. L. , Lanoisellé M. , White B. , Wooster M. J. , Zhang T. , Nisbet E. G. 
Published: September 2017

AbstractTropical methane sources are an important part of the global methane budget and include natural wetlands, rice agriculture, biomass burning, ruminants, fossil fuels, and waste. δ13CCH4 can provide strong constraints on methane source apportionment. For example, tropical wetlands in this study give δ13CCH4 values between −61.5 ± 2.9‰ and −53.0 ± 0.4‰ and in general are more enriched in 13C than temperate and boreal wetlands. However, thus far, relatively few measurements of δ13CCH4 in methane‐enriched air have been made in the tropics. In this study samples have been collected from tropical wetland, rice, ruminant, and biomass burning emissions to the atmosphere. Regional isotopic signatures vary greatly as different processes and source material affect methane signatures. Measurements were made to determine bulk source inputs to the atmosphere, rather than to study individual processes. These measurements provide inputs for regional methane budget models, to constrain emissions with better source apportionment.
Enhanced Reversible Sodium‐Ion Intercalation by Synergistic Coupling of Few‐Layered MoS2 and S‐Doped Graphene
Authors: Li Ge , Luo Dan , Wang Xiaolei , Seo Min Ho , Hemmati Sahar , Yu Aiping , Chen Zhongwei 
Published: September 2017

AbstractSodium‐ion batteries (SIBs) are regarded as the best alternative to lithium‐ion batteries due to their low cost and similar Na+ insertion chemistry. It is still challenging but greatly desired to design and develop novel electrode materials with high reversible capacity, long cycling life, and good rate capability toward high‐performance SIBs. This work demonstrates an innovative design strategy and a development of few‐layered molybdenum disulfide/sulfur‐doped graphene nanosheets (MoS2/SG) composites as the SIB anode material providing a high specific capacity of 587 mA h g−1 calculated based on the total composite mass and an extremely long cycling stability over 1000 cycles at a current density of 1.0 A g−1 with a high capacity retention of ≈85%. Systematic characterizations reveal that the outstanding performance is mainly attributed to the unique and robust composite architecture where few‐layered MoS2 and S‐doped graphene are intimately bridged at the hetero‐interface through a synergistic coupling effect via the covalently doped S atoms. The design strategy and mechanism understanding at the molecular level outlined here can be readily applied to other layered transition metal oxides for SIBs anode and play a key role in contributing to the development of high‐performance SIBs.
Hydroxypropyl‐β‐cyclodextrin hybrid nanogels as nano‐drug delivery carriers to enhance the solubility of dexibuprofen: Characterization, in vitro release, and acute oral toxicity studies
Authors: Khalid Qandeel , Ahmad Mahmood , Usman Minhas Muhammad 
Published: September 2017

AbstractThe purpose of this study was to develop and characterize hydroxypropyl‐β‐cyclodextrin (HPβCD) hybrid nanogels for solubility enhancement of lipophilic drug, dexibuprofen. HPβCD hybrid nanogels were designed by chemical cross‐linking of hydroxypropyl‐β‐cyclodextrin with 2‐acrylamido‐2‐methyl propane sulfonic acid (AMPS) via free radical polymerization. Loading efficiency, solubilization, zetasizer, FESEM Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), powder X‐ray diffraction (PXRD), and in vitro drug release analysis were performed for characterization of hybrid nanogels. Efficient solubilization of dexibuprofen has been observed by HPβCD hybrid nanogels. FTIR, TGA, and DSC studies confirmed the formation of new hybrid nanogels and complexation of dexibuprofen with nanogels. XRD analysis revealed loss of dexibuprofen crystallinity in hybrid nanogels. Highly porous and amorphous nanogels showed a significant dexibuprofen release in aqueous medium. In toxicity studies, no significant changes in behavioral, physiological, biochemical, or histopathological parameters of animals endorsed that developed formulations are nontoxic and biocompatible.
Resting heart rate, heart rate reserve, and metabolic syndrome in professional firefighters: A cross‐sectional study
Authors: Choi BongKyoo , Ko SangBaek , Kojaku Stacey 
Published: September 2017

BackgroundLittle is known about the associations of resting heart rate (RHR) and heart rate reserve (HRR) with metabolic syndrome (MetS) in firefighters.MethodsFor each of 288 professional firefighters, HRR was calculated as the difference between measured RHR and estimated maximum HR. For comparison, VO2 max based on a treadmill test was included. MetS was defined according to the NCEP/ATP III criteria.ResultsThe prevalence of MetS was 14.2%. The average of RHR was 61.5 beat/min. Only 5.8% of the firefighters had RHR of ≥80 beat/min. Between the firefighters in the lowest and highest quintiles, the prevalence ratios (95% confidence intervals) for MetS were 1.88 (0.71‐4.94), 5.90 (1.74‐20.02), and 8.03 (1.86‐34.75) for RHR, HRR, and VO2 max, respectively. Both HRR and VO2 max, but not RHR, were significantly associated with MetS and its most component risk factors in middle‐aged firefighters.ConclusionsHRR, a simple cardiovascular fitness measure, was inversely associated with MetS among middle‐aged professional firefighters.
AFM Imaging of Hybridization Chain Reaction Mediated Signal Transmission between Two DNA Origami Structures
Authors: Helmig Sarah , Gothelf Kurt Vesterager 
Published: September 2017

AbstractSignal transfer is central to the controlled exchange of information in biology and advanced technologies. Therefore, the development of reliable, long‐range signal transfer systems for artificial nanoscale assemblies is of great scientific interest. We have designed such a system for the signal transfer between two connected DNA nanostructures, using the hybridization chain reaction (HCR). Two sets of metastable DNA hairpins, one of which is immobilized at specific points along tracks on DNA origami structures, are polymerized to form a continuous DNA duplex, which is visible using atomic force microscopy (AFM). Upon addition of a designed initiator, the initiation signal is efficiently transferred more than 200 nm from a specific location on one origami structure to an end point on another origami structure. The system shows no significant loss of signal when crossing from one nanostructure to another and, therefore, has the potential to be applied to larger multi‐component DNA assemblies.
Ultrafast Vibrational Dynamics of Membrane‐Bound Peptides at the Lipid Bilayer/Water Interface
Authors: Tan Junjun , Zhang Baixiong , Luo Yi , Ye Shuji 
Published: September 2017

AbstractVibrational energy transfer (VET) of proteins at cell membrane plays critical roles in controlling the protein functionalities, but its detection is very challenging. By using a surface‐sensitive femtosecond time‐resolved sum‐frequency generation vibrational spectroscopy with infrared pump, the detection of the ultrafast VET in proteins at cell membrane has finally become possible. The vibrational relaxation time of the N−H groups is determined to be 1.70(±0.05) ps for the α‐helix located in the hydrophobic core of the lipid bilayer and 0.9(±0.05) ps for the membrane‐bound β‐sheet structure. The N−H groups with strong hydrogen bonding gain faster relaxation time. By pumping the amide A band and probing amide I band, the vibrational relaxation from N−H mode to C=O mode through two pathways (direct coupling and through intermediate states) is revealed. The ratio of the pathways depends on the NH⋅⋅⋅O=C hydrogen‐bonding strength. Strong hydrogen bonding favors the coupling through intermediate states.
Three‐Dimensional Hierarchical Architectures Derived from Surface‐Mounted Metal–Organic Framework Membranes for Enhanced Electrocatalysis
Authors: Jia Gan , Zhang Wen , Fan Guozheng , Li Zhaosheng , Fu Degang , Hao Weichang , Yuan Chunwei , Zou Zhigang 
Published: September 2017

AbstractInspired by the rapid development of metal–organic‐framework‐derived materials in various applications, a facile synthetic strategy was developed for fabrication of 3D hierarchical nanoarchitectures. A surface‐mounted metal–organic framework membrane was pyrolyzed at a range of temperatures to produce catalysts with excellent trifunctional electrocatalytic efficiencies for the oxygen reduction, hydrogen evolution, and oxygen evolution reactions.
Acetylshikonin is a novel non‐selective cytochrome P450 inhibitor
Authors: Shon Jong Cheol , Phuc Nguyen Minh , Kim Won Cheol , Heo Jae Kyung , Wu Zhexue , Lee Hyunyoung , Liu Kwang‐Hyeon 
Published: September 2017

AbstractAcetylshikonin is a biologically active compound with anti‐cancer and anti‐inflammatory activity, which is isolated from the roots of Lithospermum erythrorhizoma. An inhibitory effect of acetylshikonin against CYP2J2 activity was discovered recently. Based on this result, this study was expanded to evaluate the inhibitory effects of acetylshikonin against nine different cytochrome P450 (P450) isoforms in human liver microsomes (HLMs) using substrate cocktails incubation assay. Acetylshikonin showed a strong inhibitory effect against all P450s tested with IC50 values of 1.4–4.0 μ
m. Pre‐incubation of acetylshikonin with HLMs and NADPH did not alter the inhibition potency, indicating that acetylshikonin is not a mechanism‐based inhibitor. SKF‐525A, a widely used non‐specific P450 inhibitor, had no inhibitory activity against CYP1A2, 2A6, 2E1 and 2J2, while it showed an inhibitory effect against CYP2B6, CYP2C19 and 2D6 with IC50 values of 2.5, 3.6 and 0.5 μ
m, respectively. Our findings indicate that acetylshikonin may be a novel general P450 inhibitor, which could replace SKF‐525A.
Sudden maternal hypoxemia during elective cesarean section in a woman with placenta previa
Authors: Umazume Takeshi , Hayasaka Satoshi , Kato Fumi , Ishikawa Satoshi , Morikawa Mamoru , Minakami Hisanori 
Published: September 2017

Key Clinical MessageThere have been no reports regarding imaging‐documented bronchospasm in patients with amniotic fluid embolism (AFE). In a woman with scheduled cesarean section for placenta previa, transient bronchospasm and pulmonary hypertension were documented explaining a sudden drop in SpO2. Mild AFE was the most likely diagnosis in this patient.
Solid‐State Reactions of Eicosaborate [B20H18]2− Salts and Complexes
Authors: Avdeeva Varvara V. , Buzin Mikhail I. , Dmitrienko Artem O. , Dorovatovskii Pavel V. , Malinina Elena A. , Kuznetsov Nikolay T. , Voronova Evgenia D. , Zubavichus Yan V. , Vologzhanina Anna V. 
Published: September 2017

AbstractA series of salts and complexes containing trans‐ and iso‐isomers of octadecahydro‐eicosaborate [B20H18]2− dianion is synthesized and characterized using FTIR and 11B NMR spectroscopies and X‐ray diffraction techniques. Both isomers are found to act as four‐, bi‐, or zero‐dentate ligands in reactions with copper(II), silver(I), and lead(II) through apical and/or equatorial boron atoms. Solid‐state photo‐ and thermoinitiated reactions of octadecahydro‐eicosaborate isomerization and solvent cleavage occurring in these compounds in a single‐crystal‐to‐single‐crystal manner are studied in situ. In contrast with solutions, in solids the reaction of boron cluster transformation occurs rarely, thus, analysis of crystal packing allowed us to suggest some criteria of isomerization of macropolyhedral boranes in crystals. X‐ray diffraction data are used to confirm reaction path of isomerization of the [B20H18]2− dianion.