bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arthroscopic Debridement and Resection of a Bennett Lesion in a Collegiate Baseball Pitcher
Authors: Loughran Galvin J. , Hollyer Ian , Helenius Kevin , Heffner Michael , Freehill Michael T. 
Published: October 2024

Background: Overhead throwing athletes are predisposed to ossification along the superior to inferior posterior glenoid rim, termed thrower's exostosis or a Bennett lesion. These lesions can result in posterior shoulder pain during throwing and decreased shoulder range of motion, and they can be associated with posterior labral tears and undersurface rotator cuff tears. In this video technique, we describe the arthroscopic debridement and resection of a symptomatic unstable Bennett lesion in a collegiate baseball pitcher who had unsuccessful nonoperative treatment. Indications: Currently, there is no standard treatment algorithm for Bennett lesions. Arthroscopic intervention is typically indicated in overhead throwers who have unsuccessful nonoperative protocols, including stretching of the posterior capsule, strengthening of the rotator cuff, and injections. Technique Description: In the lateral decubitus position, standard posterior viewing and anterior working arthroscopic portals are created followed by diagnostic arthroscopy. A high anterior accessory portal is created to view the posterior labrum and evaluate for tears. The location of the Bennett lesion is determined using a switching stick or probe. In this case, an accessory posterior viewing portal and capsulotomy are created under spinal needle visualization and a 70° scope is utilized for an improved view. Through the capsulotomy, a motorized shaver and radiofrequency wand is used to work along the posterior inferior glenoid neck to expose the lesion. Once the lesion is fully demarked, a hooded bur is utilized to debride the entirety of the lesion back to the smooth bony surface of the glenoid neck. After resection, the capsule is left open to avoid overtightening the posterior capsule in overhead throwing athletes. Results: Arthroscopic debridement and resection of a symptomatic Bennett lesion in a collegiate baseball pitcher allowed the patient to return to pain-free pitching at the same level of collegiate play the following season. Discussion/Conclusion: An unstable Bennett lesion can be a source of pain in the overhead throwing athlete. If nonoperative treatment modalities fail to resolve symptoms, arthroscopic debridement and excision of this lesion utilizing a posterior capsulotomy and accessory posterior viewing portal as described in this video technique is a safe and effective surgical option. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Combined influence of physical activity and C-reactive protein to albumin ratio on mortality among older cancer survivors in the United States: a prospective cohort study
Authors: An Xiaoqin , Li Jingyi , Li Yuan , Liu Huanxian , Bai Junjun , Guo Qinxiang , Jiao Baoping 
Published: October 2024

Abstract
Background
Although a high C-reactive protein-to-albumin ratio (CAR) is believed to increase mortality risk, the association between the physical activity (PA), CAR, and mortality among cancer survivors has not been investigated. This study aimed to examine this association among cancer survivors in the United States.

Methods
This cohort study used data from the National Health and Nutrition Examination Survey from 1999 to 2010. PA was self-reported using the Global Physical Activity Questionnaire, and C-reactive protein and albumin levels were obtained from laboratory data files. Mortality data were obtained by linkage of the cohort database to the National Death Index as of December 31, 2019. The analysis was conducted from November 1 to December 31, 2023. We used Cox proportional hazards multivariable regression to assess hazard ratios (HRs) and 95% confidence interval (CIs) for total and cancer-specific mortality risks attributable to PA and CAR.

Results
Among 2,232 cancer survivors, 325 (14.6%) reported no PA with a high CAR. During a follow-up of up to 20.75 years (median, 12.3 years; 27,453 person-years), 1,174 deaths occurred (cancer, 335; other, 839). A high CAR was observed to be consistently associated with the highest risks of total (HR, 1.59; 95% CI, 1.37–1.85) and cancer-specific (HR, 2.06; 95% CI, 1.55–2.73) mortality compared with a low CAR in a series of adjusted models. Multivariable models showed that PA was associated with a lower risk of all-cause (HR, 0.60; 95% CI, 0.52–0.69) and cancer-specific (HR, 0.64; 95% CI, 0.49–0.84) mortality compared with no PA. In the joint analyses, survivors with PA ≥ 600 metabolic equivalent min/wk and a low CAR were more likely to reduce the risk of total (HR, 0.41; 95% CI, 0.32–0.51) and cancer-specific (HR, 0.32; 95% CI, 0.20–0.50) mortality by 59% and 68% compared with those with no PA and a high CAR.

Conclusion
The pairing of adequate PA and a low CAR was significantly associated with reduced all-cause and cancer-related mortality risks.
Protecting whose welfare? A document analysis of competition regulatory decisions in four jurisdictions across three harmful consumer product industries
Authors: Wood Benjamin , Karouzakis Chrissa , Sievert Katherine , Gallasch Sven , Sacks Gary 
Published: October 2024

Abstract
Background and methods
Competition regulation has a strong influence on the relative market power of firms. As such, competition regulation can complement industry-specific measures designed to address harms associated with excessive market power in harmful consumer product industries. This study aimed to examine, through a public health lens, assessments and decisions made by competition authorities in four jurisdictions (Australia, South Africa, the United States (US), and the European Union (EU)) involving three harmful consumer product industries (alcoholic beverages, soft drinks, tobacco). We analysed legal case documents, sourced from online public registers and dating back as far as the online records extended, using a narrative approach. Regulatory decisions and harms described by the authorities were inductively coded, focusing on the affected group(s) (e.g., consumers) and the nature of the harms (e.g., price increases) identified.

Results
We identified 359 cases published by competition authorities in Australia (n = 202), South Africa (n = 44), the US (n = 27), and the EU (n = 86). Most cases (n = 239) related to mergers and acquisitions (M&As). Competition authorities in Australia, the US, and the EU were found to make many decisions oriented towards increasing the affordability and accessibility of alcohol beverages, soft drinks, and tobacco products. Such decisions were very often made despite the presence of consumption-reduction public health policies. In comparison, South Africa’s competition authorities routinely considered broader issues, including ‘Black Economic Empowerment’ and potential harms to workers.

Conclusion
Many of the competition regulatory decisions assessed likely facilitated the concentration of market power in the industries we explored. Nevertheless, there appears to be potential for competition regulatory frameworks to play a more prominent role in promoting and protecting the public’s health through tighter regulation of excessive market power in harmful consumer product industries.
Population structure analysis of Phlebotomus papatasi populations using transcriptome microsatellites: possible implications for leishmaniasis control and vaccine development
Authors: Hamarsheh Omar , Guernaoui Souad , Karakus Mehmet , Yaghoobi-Ershadi Mohammad Reza , Kruger Andreas , Amro Ahmad , Kenawy Mohamed Amin , Dokhan Mostafa Ramadhan , Shoue Douglas A. , McDowell Mary Ann 
Published: October 2024

Abstract
Background
Phlebotomus papatasi is considered the primary vector of Leishmania major parasites that cause zoonotic cutaneous leishmaniasis (ZCL) in the Middle East and North Africa. Phlebotomus papatasi populations have been studied extensively, revealing the existence of different genetic populations and subpopulations over its large distribution range. Genetic diversity and population structure analysis using transcriptome microsatellite markers is important to uncover the vector distribution dynamics, essential for controlling ZCL in endemic areas.

Methods
In this study, we investigated the level of genetic variation using expressed sequence tag-derived simple sequence repeats (EST-SSRs) among field and colony P. papatasi samples collected from 25 different locations in 11 countries. A total of 302 P. papatasi sand fly individuals were analyzed, including at least 10 flies from each region.

Results
The analysis revealed a high-level population structure expressed by five distinct populations A through E, with moderate genetic differentiation among all populations. These genetic differences in expressed genes may enable P. papatasi to adapt to different environmental conditions along its distribution range and likely affect dispersal.

Conclusions
Elucidating the population structuring of P. papatasi is essential to L. major containment efforts in endemic countries. Moreover, the level of genetic variation among these populations may improve our understanding of Leishmania–sand fly interactions and contribute to the efforts of vaccine development based on P. papatasi salivary proteins.

Graphical Abstract
A single amplified genome catalog reveals the dynamics of mobilome and resistome in the human microbiome
Authors: Kawano-Sugaya Tetsuro , Arikawa Koji , Saeki Tatsuya , Endoh Taruho , Kamata Kazuma , Matsuhashi Ayumi , Hosokawa Masahito 
Published: October 2024

Abstract
Background
The increase in metagenome-assembled genomes (MAGs) has advanced our understanding of the functional characterization and taxonomic assignment within the human microbiome. However, MAGs, as population consensus genomes, often aggregate heterogeneity among species and strains, thereby obfuscating the precise relationships between microbial hosts and mobile genetic elements (MGEs). In contrast, single amplified genomes (SAGs) derived via single-cell genome sequencing can capture individual genomic content, including MGEs.

Results
We introduce the first substantial SAG dataset (bbsag20) from the human oral and gut microbiome, comprising 17,202 SAGs above medium-quality without co-assembly. This collection unveils a diversity of bacterial lineages across 312 oral and 647 gut species, demonstrating different taxonomic compositions from MAGs. Moreover, the SAGs showed cellular-level evidence of the translocation of oral bacteria to the gut. We also identified broad-host-range MGEs harboring antibiotic resistance genes (ARGs), which were not detected in the MAGs.

Conclusions
The difference in taxonomic composition between SAGs and MAGs indicates that combining both methods would be effective in expanding the genome catalog. By connecting mobilomes and resistomes in individual samples, SAGs could meticulously chart a dynamic network of ARGs on MGEs, pinpointing potential ARG reservoirs and their spreading patterns in the microbial community.
Inflammatory and genomic interactions within keratoconus susceptible patients: a nationwide registered case–control study
Authors: Doroodgar Farideh , Alizadeh Fatemeh , Niazi Sana , Razavi Seyedeh Maryam , Jalilian Nazanin , Azarnezhad Asaad , Niazi Feizollah , Javadi Mohammad Ali , Alió del Barrio Jorge , Dehghani Shima , Moshirfar Majid , Gatzioufas Zisis , Ambrósio Renato , Alio Jorge L. 
Published: October 2024

Abstract
Purpose
This study aimed to investigate the association between variants in the interleukin (IL)-1 gene cluster and susceptibility to keratoconus (KC) in an Iranian population.

Methods
In the case group, there were 188 KC patients diagnosed by clinical findings and corneal tomography. The control group included all 205 healthy controls with no personal or family history of eye-related, metabolic, or immune system-related disease. Using the standard salting out extraction procedure, genomic DNA was isolated from peripheral blood leukocytes. The genotypes were determined by applying agarose gel electrophoresis for the IL-1RN 86 bp VNTR and polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) for rs16944 and rs1143634.

Results
The results showed a significant association between the IL-1β rs1143634 (rs1143634 T allele, P = 0.008) and IL-1RN 86 bp VNTR polymorphisms (LL and LS genotype, P = 0.048 and 0.012 respectively) and susceptibility to KC in the Iranian population. The genotype distributions of rs1143634 (P = 0.004) and rs2234663 (P = 0.042) significantly differed between case and control groups, with certain genotypes demonstrating a protective effect against KC. Logistic regression analysis revealed a protective effect of the IL-1RN L allele [odds ratio (OR) = 0.367, 95% confidence interval (CI): 0.240–0.562; P = 0.000] and certain haplotypes (OR = 0.628, 95% CI: 0.447–0.884; P = 0.007) against KC. However, no significant association was found for the IL-1β rs16944 polymorphism.

Conclusion
This study provides evidence for an association between variants in the IL-1 gene cluster and susceptibility to KC in an Iranian population. Further research on larger and more diverse populations is warranted to validate these findings and explore the underlying mechanisms involved.
Technical sandbox for a Global Patient co-Owned Cloud (GPOC)
Authors: Davids Joe , ElSharkawy Mohamed , Ashrafian Hutan , Herlenius Eric , Lidströmer Niklas 
Published: October 2024

Abstract
Background
The use of Cloud-based storage personal health records has increased globally. The GPOC series introduces the concept of a Global Patient co-Owned Cloud (GPOC) of personal health records. Technical sandboxes allow the capability to simulate different scientific concepts before making them production ready. None exist for the medical fields and cloud-based research.

Methods
We constructed and tested the sandbox using open-source infrastructures (Ubuntu, Alpine Linux, and Colaboratory) and demonstrated it on a cloud platform. Data preprocessing utilised standard and in-house libraries. The Mina protocol, implementing zero-knowledge proofs, ensured secure blockchain operations, while the Ethereum smart contract protocol within Hyperledger Besu supported enterprise-grade sandbox development.

Results
Here, we present the GPOC series’ technical sandbox. This is to facilitate future online research and testing of the concept and its security, encryption, movability, research potential, risks and structure. It has several protocols for homomorphic encryption, decentralisation, transfers, and file management.
The sandbox is openly available online and tests authorisation, transmission, access control, and integrity live. It invites all committed parties to test and improve the platform. Individual patients, clinics, organisations and regulators are invited to test and develop the concept.
The sandbox displays co-ownership of personal health records. Here it is trisected between patients, clinics and clinicians. Patients can actively participate in research and control their health data. The challenges include ensuring that a unified underlying protocol is maintained for cross-border delivery of care based on data management regulations.

Conclusions
The GPOC concept, as demonstrated by the GPOC Sandbox, represents an advancement in healthcare technology. By promoting patient co-ownership and utilising advanced technologies like blockchain and homomorphic encryption, the GPOC initiative enhances individual control over health data and facilitates collaborative medical research globally. The justification for this research lies in its potential to improve evidence-based medicine and AI dissemination. The significance of the GPOC initiative extends to various aspects of healthcare, patient co-ownership of health data, promoting access to resources and healthcare democratisation. The implications include better global health outcomes through continued development and collaboration, ensuring the successful adoption of the GPOC Sandbox and advancing innovation in digital health.
Medico-legal psychiatric assessments in the age of video-linking
Authors: Briscoe James 
Published: October 2024

SUMMARYFollowing the COVID-19 pandemic, assessments by video link became a standard and acceptable form of medico-legal evaluation. The various challenges to achieving an accurate and robust medico-legal assessment via a remote platform are explored in this clinical reflection. It is concluded that any limitations to a remotely undertaken assessment must be highlighted to the court and an in-person assessment considered as a reasonable alternative in some cases.
Comprehensive Literature Review of the use of The Bakri Balloon for Managing Postpartum Hemorrhage
Authors: Kowal Joanna , Połujański Paweł , Cyran Piotr , Jaroszyńska Anna , Jaroszyński Filip , Paleczny Jan , Parobczak Robert , Winciorek Joanna , Wiśniewska Adrianna 
Published: October 2024

Postpartum hemorrhage (PPH) remains a significant cause of maternal mortality and morbidity worldwide. It is defined as excessive bleeding, typically more than 500 ml of blood loss within the first 24 hours after childbirth. The Bakri Balloon technique has emerged as a promising solution for managing PPH, offering a minimally invasive approach to achieving hemostasis and preventing the need for more invasive surgical procedures.
Aims: The aim of this paper review is to provide an overview of the effectiveness of intrauterine balloon tamponade in managing PPH.
Methods: We conducted this paper review by selecting articles, retrospective cohort studies and reviews from clinical trials from PubMed.
Results: Numerous studies have shown high success rates of treating PPH using The Bakri Balloon intrauterine tamponade.
Conclusions: The Bakri Balloon intrauterine tamponade is an effective method in the management of primary postpartum hemorrhage.
Uso da Comunicação Não Violenta na Análise de Cenários de Conflitos em Engenharia de Requisitos
Authors: Barbosa Aline Ferreira , Lencastre Maria 
Published: October 2024

A Engenharia de Requisitos envolve inúmeras interações sociais, que requerem do analista um alto nível de cooperação e empatia com pessoas de personalidades, valores e interesses diferentes. Nas equipes de desenvolvimento de software, independentemente do tamanho que seja o projeto, os conflitos fazem parte do seu ciclo de vida. Portanto, é importante o analista de requisitos monitorar continuamente os sinais que apontam a existência de conflitos, evitando o comprometimento do projeto. Este artigo se concentra em identificar cenários de conflitos recorrentes nas equipes de desenvolvimento de software e utiliza uma estratégia para análise dos mesmos, a Comunicação Não Violenta (CNV). Foi realizado um estudo qualitativo utilizando como método de coleta uma entrevista semiestruturada com profissionais de 9 empresas distintas visando um aprofundamento nas situações de conflitos identificadas. Foram levantados um conjunto de cenários de conflito reais, assim como feita a análise dos mesmos, com base na CNV; isto ajudou os participantes (entrevistados) a observar o fato, independente de julgamentos, assim como identificar os sentimentos e necessidades presentes na situação; dessa forma, eles passaram a ter uma melhor compreensão do cenário onde ocorreu o conflito.
Direcionadores para o Desenvolvimento Baseado em Modelos de Software Embarcado Aeronáutico
Authors: Sarkis André , Marques Johnny , Vieira Dias Luiz Alberto 
Published: October 2024

O Desenvolvimento Baseado em Modelos (MBD, Model-Based Development) pode ser usado para especificar requisitos em vários níveis: produto, sistema, ou de software. Na área de aviação, o uso de normas regulatórias no processo de certificação é usualmente requerido. A RTCA DO-178C e seus suplementos legislam sobre as necessidades que o processo de desenvolvimento de software precisa atender para tornar o produto de software certificável. Nos últimos anos, é notável o crescimento no uso de modelagem. Assim, o objetivo deste artigo é apresentar um conjunto de direcionadores para o MDB em Software Embarcado Aeronáutico, garantindo o atendimento às normas DO-178C e DO-331. Além dos direcionadores, é apresentado um estudo de caso.
Effects of Postmanufacture Conditioning on the Mechanical and Hygroscopic Properties of Extrusion Printed Wood–Sodium Silicate Composites
Authors: Alade Adefemi A. , Hematabadi Hojat , Carne Robert H. R. , Kukal Japneet , Fu Audrey Q. , McDonald Armando G. , Maughan Michael R. , Ibrahim Ahmed A. , Robertson Daniel J. 
Published: October 2024

Abstract
Additive manufacturing of wood–sodium silicate composites could aid in mitigating the carbon footprint of the building and construction industry. However, the effect of postmanufacture conditioning on the mechanical and physical properties of additively manufactured wood–sodium silicate composites is not well understood. This study investigated eight different postmanufacture drying processes, including: ambient indoor and outdoor conditions, oven-drying at two different temperatures, microwave drying, alcohol-induced dehydration using ethanol and denatured alcohol, and desiccant drying. Each postmanufacture conditioning treatment was assessed in terms of total moisture extraction and moisture extraction rate as well as the flexural strength, flexural stiffness, and hardness of the wood–sodium silicate samples after drying. In addition, the water absorption and volumetric swelling properties of the additively manufactured wood–sodium silicate samples were assessed via water submersion tests. The postmanufacture conditioning treatments were found to significantly affect the mechanical and physical properties of the samples. A universal ranking system was established based on cumulative rankings of each evaluated characteristic. Samples dried in ambient outdoor conditions achieved the best overall ranking and had the smallest carbon footprint. However, ovendried samples had the best flexural properties. Future studies investigating hybrid approaches in which composites are sequentially subjected to different drying methods will likely provide the most desirable mechanical and physical properties of wood–sodium silicate composites.