bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated volumetry of hippocampus is useful to confirm unilateral mesial temporal sclerosis in patients with radiologically positive findings
Authors: Silva Guilherme , Martins Cristina , Moreira da Silva Nádia , Vieira Duarte , Costa Dias , Rego Ricardo , Fonseca José , Silva Cunha João Paulo 
Published: June 2017

Background and purpose We evaluated two methods to identify mesial temporal sclerosis (MTS): visual inspection by experienced epilepsy neuroradiologists based on structural magnetic resonance imaging sequences and automated hippocampal volumetry provided by a processing pipeline based on the FMRIB Software Library. Methods This retrospective study included patients from the epilepsy monitoring unit database of our institution. All patients underwent brain magnetic resonance imaging in 1.5T and 3T scanners with protocols that included thin coronal T2, T1 and fluid-attenuated inversion recovery and isometric T1 acquisitions. Two neuroradiologists with experience in epilepsy and blinded to clinical data evaluated magnetic resonance images for the diagnosis of MTS. The diagnosis of MTS based on an automated method included the calculation of a volumetric asymmetry index between the two hippocampi of each patient and a threshold value to define the presence of MTS obtained through statistical tests (receiver operating characteristics curve). Hippocampi were segmented for volumetric quantification using the FIRST tool and fslstats from the FMRIB Software Library. Results The final cohort included 19 patients with unilateral MTS (14 left side): 14 women and a mean age of 43.4 ± 10.4 years. Neuroradiologists had a sensitivity of 100% and specificity of 73.3% to detect MTS (gold standard, k = 0.755). Automated hippocampal volumetry had a sensitivity of 84.2% and specificity of 86.7% (k = 0.704). Combined, these methods had a sensitivity of 84.2% and a specificity of 100% (k = 0.825). Conclusions Automated volumetry of the hippocampus could play an important role in temporal lobe epilepsy evaluation, namely on confirmation of unilateral MTS diagnosis in patients with radiological suggestive findings.
Surgical, medical and developmental outcomes in patients with Down syndrome and cataracts
Authors: Santoro Stephanie L , Atoum Dema , Hufnagel Robert B , Motley William W 
Published: June 2017

Background: Individuals with Down syndrome have an increased risk for congenital cataracts, but descriptions of surgical, medical and developmental outcomes are sparse. Materials and Methods: Retrospective review of medical charts of patients with Down syndrome with visits to Cincinnati Children’s Hospital from 1988 to 2013 was performed. A case series of five patients with Down syndrome and cataracts is presented. A total of 47 patients with Down syndrome without cataracts were used as a developmental control. Developmental quotients were compared using an independent-sample, unequal variance t-test. Results: Post-operative cataract complication rates ranged from 20% to 60%. Visual outcomes were varied; significant associations between complication rate and visual outcome were not found. Developmental quotients did not show an association with number of complications, but were lower for children with Down syndrome with cataracts requiring surgery compared to children with Down syndrome without cataracts. Conclusion: In children with Down syndrome and congenital cataract, surgical intervention has risk for post-operative complications. Further investigation is needed to determine if there is an association between surgical complications and visual or developmental outcomes.
Therapeutic drug monitoring for colistin therapy in severe multi-resistant Acinetobacter intracerebral abscess: A single case study with high-dose colistin and review of literature
Authors: Tafelski Sascha , Wagner Lukas , Angermair Stefan , Deja Maria ,   for the ABx Study Group
Published: June 2017

Objectives: Intracranial infections due to multidrug- resistant (MDR) gram-negative pathogens are associated with increased morbidity and mortality. As therapeutic options are limited and systemic drug penetration into the infection focus is difficult, intraventricular therapy has been described. Methods: We report on a patient with intracranial abscess caused by MDR Acinetobacter baumannii. Results: He was treated with high doses of intravenous and intraventricular colistin resulting in microbiological clearance and clinical cure. Therapy was controlled by therapeutic drug monitoring (TDM) of serum and liquor colistin levels. About 100 cases with intraventricular or intrathecal colistin are reported in literature but data on TDM are sparse. Conclusions: This is one of the first cases providing data on TDM for locally administered high dose colistin therapy for the treatment of intracranial abscess formations. Based on these findings, increasing the intraventricular application interval paralleled with intravenous colistin could possibly be sufficient to achieve appropriate therapeutic drug levels. Further studies are needed to support alternative dosing strategies in similar cases.
Genetic variants in ADAMTS13 as well as smoking are major determinants of plasma ADAMTS13 levels
Authors: Ma Qianyi , Jacobi Paula M. , Emmer Brian T. , Kretz Colin A. , Ozel Ayse Bilge , McGee Beth , Kimchi-Sarfaty Chava , Ginsburg David , Li Jun Z. , Desch Karl C. 
Published: June 2017

Key Points
Three independent association signals at ADAMTS13 and smoking were identified as major predictors of plasma ADAMTS13 levels. Evidence was presented that 2 nonsynonymous ADAMTS13 variants were driving the variation of plasma ADAMTS13 concentrations.
Hyperprolactinaemia: A guide for psychiatrists
Authors: Wadoo Ovais , Shah Aadil Jan , Hall Rachael , Mamoojee Yaasir 
Published: June 2017

SummaryMedications prescribed by psychiatrists are known to elevate serum prolactin levels, but hyperprolactinaemia remains underrecognised, as the adverse effects of an elevated prolactin are mostly not visible. Hyperprolactinaemia can lead to adverse health outcomes, so clinicians need not only to be alert to its symptoms, but to manage the consequences as well. In this article we provide a brief overview of prolactin physiology, regulation and function. We list various factors that can lead to elevated serum prolactin. We discuss the interpretation of blood results and the management of psychotropic-induced hyperprolactinaemia. We include a flow diagram to assist clinicians in decision-making in the clinical management of hyperprolactinaemia.Learning Objectives• Understand prolactin physiology and regulation• Understand hyperprolactinaemia and its causes• Know the consequences of hyperprolactinaemia and appropriately manage it in clinical practice
Moral responsibility in psychopathy: A clinicophilosophical case discussion
Authors: Ramplin Steve , Ayob Gloria 
Published: June 2017

SummaryThis article examines the concept of moral responsibility in psychopathy. In doing so it shows how philosophical ideas can be used to help approach a complex issue in psychiatry. Building on a fictitious case, we explore two arguments: the exempting view, which proposes that psychopaths lack any ability to function as moral agents; and the mitigating view, which concedes that there are impairments in moral understanding in psychopathy, but takes these to be insufficient to be completely exempting, instead concluding that such individuals are at least partially morally responsible. Typically, clinicians (and the courts) are more comfortable with a mitigating view, whereas philosophers tend to extol an exempting view. Through discussion of the case, we illustrate the value that philosophy brings to clinical psychiatry and the ways in which psychiatry can enrich philosophical debate.Learning Objectives• Appreciate the diversity of views about moral responsibility in psychopathy, ranging from mitigation to exemption• Understand the philosophical arguments used to support both the mitigating and exempting views• Consider the benefits of philosophical reasoning in explicating a complex problem in psychiatry
Quality improvement for psychiatrists
Authors: Holt Genevieve , Ryland Howard , Shah Amar 
Published: June 2017

SummaryQuality improvement (QI) offers a route to transforming care delivery at the scale and pace needed to ensure sustainability in the National Health Service. However, it is a complex endeavour with numerous challenges to consider, and it takes time. There are many ways of understanding quality and QI in healthcare, and it is important for doctors to develop knowledge of the core principles of QI, which increasingly feature in clinical settings and in training curricula for healthcare professionals.Learning Objectives• Describe what QI means in healthcare contexts and explain how it is different from clinical audit• Identify when QI methodology can add value to efforts to improve quality in clinical settings• Describe contextual factors that influence the effectiveness with which QI can be applied
Deaf people: What every clinician needs to know
Authors: du Feu Margaret 
Published: June 2017

SummaryDeafness is a common and varied medical, social and psychological construct that affects a significant proportion of the population. Restricted communication and uninformed attitudes have adverse effects on the physical and mental health of deaf people. Clinicians need to know how to recognise and resolve these difficulties.Learning Objectives• Be aware of the high prevalence and diverse nature of deafness• Recognise the importance of effective communication and how to achieve this with deaf people• Understand the potential impact of deafness on mental and physical health
Risk Factors for the Development of Delayed TSH Elevation in Neonatal Intensive Care Unit Newborns
Authors: Zung Amnon , Bier Palmon Rachel , Golan Agneta , Troitzky Mara , Eventov-Friedman Smadar , Marom Ronella , Keidar Rimona , Kats Neri , Almashanu Shlomo , Flidel-Rimon Orna 
Published: June 2017

Abstract

Context
Delayed thyrotropin (TSH) elevation (dTSH) is defined as elevated TSH at the second neonatal screening (after normal TSH levels at the initial screening) in premature, low-birth-weight, and ill newborns, mostly in the neonatal intensive care unit (NICU) setting. The pathogenesis of dTSH is elusive.

Objective
To identify the risk factors for dTSH development among newborns in the NICU.

Design, Setting, and Patients
A retrospective medical record review of neonates with dTSH was conducted in eight university-affiliated NICUs. Two controls were selected for each patient, matched for sex and birth weight. The risk factors for dTSH were identified by univariate analysis, followed by multivariate analysis.

Main Outcome Measures
Maternal variables, types of NICU treatments and procedures, syndromes, and various medical conditions were compared between dTSH patients and their matched controls.

Results
We enrolled 100 dTSH patients and 200 matched controls and 46 variables were compared between the two groups. Twelve risk factors for dTSH were identified on univariate analysis: cesarean section, mechanical ventilation, patent ductus arteriosus (PDA), pneumothorax, and administration of cefotaxime, vancomycin, fluconazole, dopamine, ibuprofen, furosemide, insulin, and packed red blood cells. On multivariate analysis, four risk factors were identified: PDA and vancomycin, insulin, and furosemide administration. In 26 twin pairs, in which one twin had dTSH, all variables presented similarly in both twins.

Conclusions
Although some variables had direct effects on pituitary–thyroid axis dysfunction, these variables, altogether, reflect the severity of the clinical conditions in the NICU, which is the common basis for dTSH.
Memória, patrimônio e reparação: políticas culturais no Brasil e o reconhecimento da história da escravidão
Authors: Forti Andrea Siqueira D'Alessandri 
Published: June 2017

O presente artigo busca relacionar a elaboração de políticas culturais com as lutas sociais das populações negras no Brasil, principalmente, aquelas ocorridas a partir de fins dos anos 1970. O objetivo é analisar, a partir de referenciais teóricos e de estudo de caso, como os resultados da implantação dessas políticas podem ser entendidos como uma reparação simbólica para esses grupos historicamente submetidos e silenciados. Assim como os usos possíveis do patrimônio e de exposições museológicas para a produção de conhecimento e ensino de história da escravidão e de cultura afro-brasileira. Palavras-chave: Memória, Patrimônio, História da escravidão.
Um balanço das formas de proteção institucionalizadas do patrimônio cultural no Brasil e o caso da cidade de Ouro Preto, MG.
Authors: Medina Leite Féres Leila 
Published: June 2017

Dentre as formas de proteção institucionalizadas do Patrimônio Cultural no Brasil, estão os mais conhecidos e utilizados instrumentos que conferem salvaguarda ao patrimônio cultural material, natural e imaterial. No presente artigo elegemos alguns mecanismos de proteção previstos em lei, buscamos compreender seu funcionamento nas políticas públicas, assim como suas aplicabilidades. Optamos por eleger a cidade de Ouro Preto, no estado de Minas Gerais, como exemplo da execução dessas políticas de proteção e do recente envolvimento da população nas tomadas de decisões envolvendo o patrimônio cultural. Palavras-chave: Patrimônio cultural, Brasil, Instrumentos de proteção, Ouro Preto.
O que é o Preserve/fe ? E como se constituiu o Centro de Preservação da História Ferroviária do Rio Grande do Sul na década de 1980?
Authors: Lewinski Cinara Isolde Koch 
Published: June 2017

Este artigo tem o objetivo de explicar como surgiu o Preserve/fe e demonstrar que a constituição do Centro de Preservação da História Ferroviária do Rio Grande do Sul na década de 1980 estava inserida num projeto nacional. Para desenvolver o assunto, utilizou-se o Museu do Trem de São Leopoldo-RS para ser o objeto de pesquisa, pois, abrigou o Centro de Preservação da História Ferroviária no Rio Grande do Sul. Deste modo, o tema será estudado com embasamento teórico na história cultural para entender a constituição da instituição referida pelo programa preservacionista do governo federal na década de 1980. Palavras-chave: Preserve, Patrimônio ferroviário, Centro de Preservação da História Ferroviária do Rio Grande do Sul.
Os ecos heroicos de Rodrigo na revista Pai d’égua: o patrimônio cultural na Amazônia
Authors: Andrade Andre Luis 
Published: June 2017

O presente artigo busca analisar a revista Pai d’égua: o patrimônio cultural da Amazônia, lançada pela Superintendência do Iphan/PA no final da década de 1990. Investigamos como as ações ali divulgadas vão de encontro à divisão proposta pela historiografia oficial do órgão, qual sejam: fases heroica e moderna e, desse modo, nos permite refletir sobre os projetos recentes da política federal de preservação do patrimônio cultural brasileiro, como o programa Casas do Patrimônio. Palavras-chave: Patrimônio cultural, Iphan, Revista Pai d’égua
A (In)visibilidade do patrimônio histórico e cultural: um estudo sobre o patrimônio do município de Rio Grande
Authors: Da Silveira Rafael Branco , Paulitsch Vivian da Silva 
Published: June 2017

O presente trabalho objetiva investigar a invisibilidade do patrimônio histórico e cultural do município de Rio Grande, estado do Rio Grande do Sul, mais especificamente o edifício da Delegacia da Polícia Federal, analisando e elencando os fatores responsáveis pelo seu desconhecimento. Com base numa pesquisa de cunho histórico, arquitetônico, cultural e social propõe-se uma mediação cultural a ser realizada no edifício cuja finalidade é despertar um olhar atento acerca do patrimônio, instigando o sentimento de pertencimento na comunidade riograndina. Palavras-chave: Patrimônio, Mediação cultural, Educação patrimonial.
Exhibition Reviews
Authors: Heckman Alma Rachel , Baydar Gülsüm 
Published: June 2017

JARDINS D’ORIENT: DE L’ALHAMBRA AU TAJ MAHAL, INSTITUT DU MONDE ARABE, PARIS, FRANCE, APRIL 19–SEPTEMBER 25, 2016
CIVIL ARCHITECTURAL MEMORY ANKARA: 1930–1980, IZMIR ARCHITECTURAL CENTER, IZMIR, TURKEY, SEPTEMBER 21–23, 2016
Glossário de morfologia dentária - Tradução para Português da terminologia usada em Inglês
Authors: Marado Luís Miguel , Cunha Cláudia , Silva Ana Maria 
Published: June 2017

A tradução de termos científicos é necessária para a adequação da “linguagem de especialidade” de cada área científica a cada língua. Para que a língua Portuguesa possa ser usada como língua de comunicação científica e internacional, é necessário encontrar harmonização linguística, através de glossários relativos a cada área científica. O objetivo deste artigo é a tradução sistemática para Português de termos científicos usados em Inglês na descrição morfológica e anatómica dentária em Antropologia, especificamente em morfologia dentária.
A tradução dos 56 termos considerados evitou a tradução literal ou por decalque e teve em conta a raiz etimológica (greco-latina) dos vocábulos Ingleses. As unidades lexicais sugeridas permitem a adequada descrição dos elementos morfológicos e anatómicos considerados.
Sein, Sache, Ordnung: Thomas von Aquin über Wahrmacher und die Beziehung des Wahrmachens
Authors: Löwe Can Laurens 
Published: June 2017

AbstractThe goal of this paper is to determine how Aquinas conceives of the truth-makers of (affirmative present-tense) propositions and the relation of truthmaking. First, I show that Aquinas describes a truth-maker, to which he refers as the “cause of truth” (
A result of uniqueness of solutions of the Shigesada–Kawasaki–Teramoto equations
Authors: Pham Du , Temam Roger 
Published: June 2017

Abstract
We derive the uniqueness of weak solutions to the Shigesada–Kawasaki–Teramoto (SKT) systems using the adjoint problem argument. Combining with [10], we then derive the well-posedness for the SKT systems in space dimension

d
≤
4

{d\leq 4}

.
Werthers verbriefte Liebe
Authors: Ungelenk Johannes 
Published: June 2017

Abstract
The article re-reads Werther’s legendary love with Roland Barthes, Jacques Derrida and Jean-Luc Nancy. It discovers a constitutive dimension of address and (postal) transfer that not only shapes Werther’s love, but also connects it to the often neglected form of the epistolary novel. Werther’s love is not tragic, and it is not all about Lotte – it is postal. Writing and loving share the constitutive dimension of addressing ‘the other’: distance does not indicate love’s failure; it turns out to be its productive principle. Werther’s love is thus not a ‘warning example,’ not the moral message of a tale – it exhibits and affirms the way modern love works. Anticipating psychoanalytic insight, love does not take place between two specific human beings, but circulates in a complex system of shifting addressees. The readers become involved in this postal system: the epistolary novel also addresses this love to us. Will we really ‘not be able to withhold [our] admiration and love’ as the editor tells us at the very beginning of Werther’s story? However – we seem to be the perfect match – as philo-logists...
Rank Structured Approximation Method for Quasi-Periodic Elliptic Problems
Authors: Khoromskij Boris , Repin Sergey 
Published: June 2017

Abstract
We consider an iteration method for solving an elliptic type boundary value problem

𝒜
⁢
u

=
f

{\mathcal{A}u=f}

, where a positive definite operator

𝒜

{\mathcal{A}}

is generated by a quasi-periodic structure
with rapidly changing coefficients (a typical period is characterized by a small
parameter ϵ). The method is based on using a simpler operator

𝒜
0

{\mathcal{A}_{0}}

(inversion of

𝒜
0

{\mathcal{A}_{0}}

is much simpler than inversion of

𝒜

{\mathcal{A}}

),
which can be viewed as a preconditioner for

𝒜

{\mathcal{A}}

. We prove contraction of the
iteration method and establish explicit estimates of the contraction
factor q. Certainly the value of q depends on the difference between

𝒜

{\mathcal{A}}

and

𝒜
0

{\mathcal{A}_{0}}

.
For typical quasi-periodic structures, we establish simple relations that
suggest an optimal

𝒜
0

{\mathcal{A}_{0}}

(in a selected set of “simple” structures) and compute the
corresponding contraction factor. Further, this allows us to deduce fully computable two-sided a posteriori estimates able to control numerical solutions on any iteration. The method is especially efficient
if the coefficients of

𝒜

{\mathcal{A}}

admit low-rank representations and if algebraic operations
are performed in tensor structured formats.
Under moderate assumptions the storage and solution complexity
of our approach depends only weakly (merely linear-logarithmically)
on the frequency parameter

1
ϵ

\frac{1}{\epsilon}

.
Semilinear Robin problems resonant at both zero and infinity
Authors: Papageorgiou Nikolaos S. , Rădulescu Vicenţiu D. 
Published: June 2017

Abstract
We consider a semilinear elliptic problem, driven by the Laplacian with Robin boundary condition. We consider a reaction term which is resonant at

±
∞

{\pm\infty}

and at 0. Using variational methods and critical groups, we show that under resonance conditions at

±
∞

{\pm\infty}

and at zero the problem has at least two nontrivial smooth solutions.
Characterizing Lie groups by controlling their zero-dimensional subgroups
Authors: Dikranjan Dikran , Shakhmatov Dmitri 
Published: June 2017

Abstract
We provide characterizations of Lie groups as compact-like groups in which all closed zero-dimensional metric (compact) subgroups are discrete.
The “compact-like” properties we consider include (local) compactness, (local) ω-boundedness, (local) countable compactness, (local) precompactness, (local)
minimality and sequential completeness.
Below is
A sample of our characterizations is as follows:
(i) A topological group is a Lie group if and only if it is locally compact and has no infinite compact metric zero-dimensional subgroups.
(ii) An abelian topological group G is a Lie group if and only if G is locally minimal, locally precompact and all closed metric zero-dimensional subgroups of G are discrete.
(iii) An abelian topological group is a compact Lie group if and only if it is minimal and has no infinite closed metric zero-dimensional subgroups.
(iv) An infinite topological group is a compact Lie group if and only if it is sequentially complete, precompact, locally minimal, contains a non-empty open connected subset
and all its compact metric zero-dimensional subgroups are finite.
Is age of menarche among school girls related to academic performance?
Authors: Al-Mathkoori Radhia , Nur Ula , Al-Taiar Abdullah 
Published: June 2017

Abstract

Background
There is strong evidence that the mean age of menarche has declined over the last few decades in developed and developing countries. This is of a major concern because of its enormous public health implications. This study aimed to estimate the age of menarche in Kuwait and investigate the association between menarcheal age and academic performance among high school girls in Kuwait.

Methods
A cross-sectional study was conducted on randomly selected female high school students from private and public high schools in all governorates in Kuwait. Data on the age of menarche were collected by self-administered questionnaire from the students, while data on academic performance were extracted from the students’ academic records.

Results
Of the 907 students we selected, 800 (88.2%) responded. The mean age of menarche was 12.33 [95% confidence interval (CI) 12.18–12.49] years. There was no evidence for significant association between age of menarche and students’ academic performance before or after adjusting for potential confounders.

Conclusion
The calculated age of menarche among contemporary girls in Kuwait is similar to that of the girls in industrialized countries. Early menarcheal age is unlikely to lead to adverse behavior that may affect academic performance in our setting.