bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Employers’ perspective on barriers and facilitators to employment of people with intellectual disability: A differential mixed‐method approach
Authors: Kocman Andreas , Fischer Linda , Weber Germain 
Published: June 2017

BackgroundObtaining employment is among the most important ambitions of people with intellectual disability. Progress towards comprehensive inclusive employment is hampered by numerous barriers. Limited research is available on these barriers and strategies to overcome them.MethodA mixed method approach in a sample of 30HR‐managers was used to assess (i) differences in perceived barriers for employment of people with specific disabilities and mental disorders; (ii) barriers specific to employing people with intellectual disability; (iii) strategies to overcome these barriers.ResultsEmployers perceive more barriers for hiring people with intellectual disability and mental disorders than for physical disabilities. Employment for this population is hampered by a perceived lack of skills and legal issues. Strategies perceived as beneficial are supplying information, changes in organizational strategies and legal changes.ConclusionsEmployers’ differentiated expectations and reservations towards hiring individuals with specific disabilities need to be taken into account to increase employment for people with intellectual disability.
Myopic market pricing and managerial myopia
Authors: Garel Alexandre 
Published: June 2017

AbstractThis paper develops a firm‐level measure of myopic market pricing, which captures the extent to which the market overvalues short‐term expected abnormal earnings relative to longer‐term ones. The empirical analysis shows that myopically priced firms manage earnings more actively and invest less in R&D. The impact of myopic market pricing is concentrated in firms where managers cater more to market pricing, that is, in firms with greater short‐term investor ownership, with CEO compensation that is more sensitive to the firm share price, and with higher equity dependence. Additional tests show that these findings are robust to the consideration of market (under)overpricing. The results suggest that when managers cater to market pricing, market myopia encourages managerial myopia.
Periodontal status and serum biomarker levels in HFE haemochromatosis patients. A case‐series study
Authors: Meuric Vincent , Lainé Fabrice , Boyer Emile , Le Gall‐David Sandrine , Oger Emmanuel , Bourgeois Denis , Bouchard Philippe , Bardou‐Jacquet Edouard , Turmel Valérie , Bonnaure‐Mallet Martine , Deugnier Yves 
Published: June 2017

AbstractAimTo investigate the association between periodontal status and serum biomarkers in patients with HFE haemochromatosis.Material and MethodsThis clinical case series included 84 HFE‐C282Y homozygous patients. Periodontal evaluation was performed using clinical attachment level, probing depth, gingival bleeding index, visible plaque index and gingival index. Serum markers of iron metabolism were collected from medical records. The relationship between serum biomarkers of iron burden and the severity of periodontitis was investigated.ResultsThe study population consisted of 47 men and 37 women, routinely treated in the Unit of Hepatology, University Hospital, Rennes. All patients presented with periodontitis (mild: n = 1, moderate: n = 37 and severe: n = 46). There was a positive association between transferrin saturation >45% and the severity of periodontitis (adjusted odds ratio = 5.49, p = .002).ConclusionSevere periodontitis is associated with the severity of iron burden in patients with HFE‐related hereditary haemochromatosis. Dental examination should be included in the initial assessment of all these patients.
“Real‐world” pediatric endocrine practice; how much is it influenced by physician's gender and region of practice. Results of an international survey
Authors: Smuel Keren , Yeshayahu Yonatan 
Published: June 2017

AbstractObjectiveTo determine whether hormonal treatments for frequent clinical cases (short stature, delayed and precocious puberty) are prescribed strictly according to clinical guidelines or based on personal tendencies, and whether the decisions correlate with physician's personal demographics (age, sex, and place of practice).MethodsCross‐sectional survey, with made‐up clinical cases, distributed to pediatric endocrinologists using 2 web‐based professional forums, Israeli and an international. The questionnaire included 8 clinical cases and 5 demographic questions regarding the physician. Differences in practice between Israeli and international endocrinologists were assessed, and correlation between the physician's gender and their decisions regarding treatment.ResultsOne hundred fifty‐five physicians responded, 28% Israeli and 72% international. In girls with early puberty, 60% of international and 26% of Israeli physicians chose not to treat with a gonadotropin‐releasing hormone agonist. In girls with short stature, 79% of Israeli and 34% of international physicians offered growth hormone treatment. In girls with early puberty, both male and female physicians responded similarly in the international group, but in the Israeli group 47% of male and 15% of female doctors would not treat. In girls with constitutional growth delay, 67% of Israeli male doctors would not treat with growth hormone compared to 30% of Israeli female physicians.ConclusionsOur study demonstrated significant practice differences between Israeli and international pediatric endocrinologists. Within the Israeli group, significant practice differences were seen between male and female physicians. Given that Israeli physicians follow the same clinical guidelines it is clear that a large “grey zone” of clinical cases exist and much of the decisions on treatment are personal and influenced by personal beliefs or gender.
Addressing unmet needs of patients with chronic diseases: Impact of the VISIT website during consultations
Authors: Lee Yew Kong , Ng Chirk Jenn , Low Wah Yun 
Published: June 2017

AbstractRationale, aims, and objectivesPatient concerns are often neglected in consultations, especially for chronic diseases where patients and providers fall into the routine of chronic disease management in consultations. One strategy to elicit patient concerns has been to ask patients to complete agenda lists before the consultation. This study aimed to explore the impact of a preconsultation agenda website in addressing patients' unmet needs during chronic disease consultations.MethodsPatients entered their concerns into a website (Values In Shared Interactions Tool (VISIT)). Doctors accessed this information via the electronic medical records before consultations. Individual in‐depth interviews were then conducted with patients and doctors on the website's impact on consultations. Interviews were transcribed verbatim and analysed thematically.ResultsThe average age (years) was 65.7 for patients (n = 8) and 35.7 for doctors (n = 7). Patients in the study entered between 1 to 6 items in the website. From postconsultation interviews, we found that the website impacted the consultation in 5 ways: (1) It facilitated patients to communicate their full agenda to doctors; (2) it helped address unmet patient needs as it gave them opportunity to raise other issues besides their chronic condition; (3) it facilitated rapport between doctor and patient; (4) it facilitated doctors to organize their consultation around the concerns the patient had listed; and (5) it disrupted the doctor's usual consultation style if the list of concerns was lengthy.ConclusionsIntegrating patient concerns into electronic health records helped to facilitate patient‐centred consultations. Doctors found this information useful but felt uneasy if the agenda list was too long or too complex. Areas for future studies include training doctors to manage complex agendas and formal evaluation of the VISIT tool.
Evaluation of genotypical antimicrobial resistance in ESBL producing Escherichia coli phylogenetic groups isolated from retail poultry meat
Authors: Klimienė Irena , Virgailis Marius , Kerzienė Sigita , Šiugždinienė Rita , Mockeliūnas Raimundas , Ružauskas Modestas 
Published: June 2017

AbstractThe aim of this study was evaluation of resistance‐encoding genes distribution among extended spectrum beta‐lactamase (ESBL)‐producing Escherichia coli isolated from retail poultry meat. A total of 123 raw poultry breasts meat samples from different batches (sample per batch) were taken from randomly selected six Lithuanian retail markets. The study showed high contamination with E. coli (92.7%), and more than half (54.0%) of the E. coli isolates were ESBL‐producing E. coli. ESBL‐producing E. coli isolates were resistant to beta‐lactams (except cefotetan), monobactams (100%), quinolones (54.5%), and aminoglycosides (33.3%). Most (85.0%) strains were attributed to phylogenetic group B1 and expressed blaCTX‐M genes associated with resistance to β‐lactam antibiotics, while blaTEM was identified more often (70.6%) in phylogenetic group A and blaSHV in phylogenetic group D (50.0%). A subgroup, B1, had the highest antimicrobial resistance rate (74.7%) and more resistance genes were detected in this subgroup. Correlations between phylogenetic groups and the genes that encoded resistance to β‐lactams were not detected. These research findings shows some link between phylogenetic group and antimicrobial resistance genes. Also it shows a high risk of spreading antimicrobial resistance encoding genes to human commensal or potential pathogenic bacteria.Practical applicationsEscherichia coli is common commensal bacteria associated with antimicrobial resistance to wide range of antimicrobials which uses in human medicine also. Genes, encoding antimicrobial resistance, could be easily spread among animals, humans or moved from animals to humans at slaughter or food processing. Even resistant bacteria damaged or killed during food processing, it is possible genetic sequences remain intact. High hygiene standards should be followed at slaughter houses and during food preparation process to avoid potential hazardous genetic material spreading to food processing workers and consumers. It could lead treatment failure in medicine, especially immunocompromised people.
Environmental Evaluation of Industry Cluster Strategies with a Life Cycle Perspective: Replacing Fossil Feedstock with Forest‐Based Feedstock and Increasing Thermal Energy Integration
Authors: Røyne Frida , Hackl Roman , Ringström Emma , Berlin Johanna 
Published: June 2017

SummarySymbiotic linkages in industry clusters in the form of interconnected materials, energy and information flows, and close proximity provide unique opportunities to develop efficient environmental strategies. The purpose of our study is to examine the practical potential of applying a life cycle approach in strategy evaluations, as the environmental impact caused by industrial symbiosis systems outside the company gates has been scarcely addressed. This is done by evaluating two strategies for an industry cluster in Sweden: (1) to replace a share of the fossil feedstock used in the industry cluster with forest‐based feedstock and (2) to improve energy efficiency through thermal energy integration. The environmental impact reduction potential of the strategies is evaluated using life cycle assessment. The ratio between investment cost and reduced global warming potential is used as an indicator to evaluate the cost‐effectiveness of the strategies. Results demonstrate the importance of applying a life cycle perspective as the assessment outcome depends heavily on whether only on‐site consequences are assessed or if upstream and downstream processes are also included. 20% of the greenhouse gas emission reduction of the energy integration strategy occurs off‐site, whereas the forest strategy has the largest reduction potential off‐site, >80%.
Neoliberal Care: Intimacy, Romance, and Drug Use in Argentine Dispossessed Populations
Authors: Epele María Esther 
Published: June 2017

ResumenBasado en el estudio etnográfico que he desarrollado por una década en barrios marginalizados de la Región Metropolitana de Buenos Aires, este artículo examina los cambios en los procesos de formación de parejas heterosexuales, el desarrollo de las prácticas localmente categorizadas como “cuidado” y sus relaciones con el consumo de drogas y supervivencia de los usuario/as de drogas. Partiendo de los desarrollos en Antropología y Ciencias Sociales sobre la problemática del cuidado en general, y cuidado de la salud en particular, el objetivo de este artículo es analizar los modos en que la formación de las parejas heterosexuales implica una solución de compromiso entre diversos procesos sociales (aislamiento territorial, vulnerabilidad en salud, encarcelamiento y muerte de jóvenes). A través de la noción de privatización del cuidado, el análisis muestra las consecuencias de estos procesos en la convivencia de estas parejas y en el refuerzo de los estereotipos de género patriarcales.
Reciprocity and Vernacular Statecraft: Andean Cooperation in Post‐disaster Highland Ecuador
Authors: Faas A. J. 
Published: June 2017

ResumenObreros cooperativos conocidos en toda la región andina como mingas, aunque exteriormente aparecen como la misma institución cultural, se practican de manera muy diferente y con distintos significados en diferentes contextos. Este estudio analiza cómo la cooperación minga llegó a exhibir patrones contrastantes, pero íntimamente relacionados, de prácticas y relaciones sociales, tanto en un pueblo afectado y desplazado por un desastre y un reasentamiento inducido por el desastre. Describo cómo los actores en estos diferentes grupos apelan a repertorios aparentemente comunes de significado y la cultura compartida, mientras se organizan de distintas maneras con el fin de acceder y controlar los recursos escasos. En un pueblo, la participación minga se sustenta en gran medida a través de las prácticas tradicionales de reciprocidad, mientras que en el otro se sostienen a través de nuevas estrategias institucionales. En el primero, se movilizan mingas para competir con otros pueblos de escasos recursos, mientras que en la segunda minga participantes compiten entre sí dentro del reasentamiento.
Glycan profiling using formalin‐fixed, paraffin‐embedded tissues: Hippeastrum hybrid lectin is a sensitive biomarker for squamous cell carcinoma of the uterine cervix
Authors: Tozawa‐Ono Akiko , Kubota Manabu , Honma Chika , Nakagawa Yuko , Yokomichi Noriyuki , Yoshioka Norihito , Tsuda Chiharu , Ohara Tatsuru , Koizumi Hirotaka , Suzuki Nao 
Published: June 2017

AbstractAimGlycosylation of proteins is altered in cancer cells and distinctive glycan structures are associated with specific cancers, but little is known about the complete glycan profile of particular tumors. In this study, glycomic analysis of squamous cell carcinoma (SCC) of the uterine cervix was performed to search for useful markers.MethodsA lectin microarray containing 45 lectins with different binding preferences that covered N‐ and O‐linked glycans was coupled with evanescent field‐activated fluorescent detection for glycomic analysis of SCC and normal squamous epithelium (NSE) of the cervix. Formalin‐fixed, paraffin‐embedded tissue specimens were obtained from 16 patients with uterine cervical cancer. Sections that included both tumor and non‐tumor tissues were examined to detect alterations of glycans based on the lectin‐binding pattern.ResultsHippeastrum hybrid lectin was found to be a sensitive marker for distinguishing SCC of the cervix from NSE. It was the best lectin for discriminating SCC from other tissues according to receiver–operator curve analysis, as it showed a high sensitivity (81.8%), a high specificity (70.1%), and a large area under the curve (0.8182). Histochemistry confirmed specific cytoplasmic staining of SCC cells by Hippeastrum hybrid lectin, while there was little staining of cervical intraepithelial neoplasia and no staining of NSE.ConclusionThe present lectin microarray technique could be applied for tissue‐based glycomic analysis of various tumors and for discovery of glycan‐related biomarkers.
Current status of non‐invasive prenatal testing in Japan
Authors: Samura Osamu , Sekizawa Akihiko , Suzumori Nobuhiro , Sasaki Aiko , Wada Seiji , Hamanoue Haruka , Hirahara Fumiki , Sawai Hideaki , Nakamura Hiroaki , Yamada Takahiro , Miura Kiyonori , Masuzaki Hideaki , Nakayama Setsuko , Okai Takashi , Kamei Yoshimasa , Namba Akira , Murotsuki Jun , Tanemoto Tomohiro , Fukushima Akimune , Haino Kazufumi , Tairaku Shinya , Matsubara Keiichi , Maeda Kazuhisa , Kaji Takashi , Ogawa Masanobu , Osada Hisao , Nishizawa Haruki , Okamoto Yoko , Kanagawa Takeshi , Kakigano Aiko , Kitagawa Michihiro , Ogawa Masaki , Izumi Shunichiro , Katagiri Yukiko , Takeshita Naoki , Kasai Yasuyo , Naruse Katsuhiko , Neki Reiko , Masuyama Hisashi , Hyodo Maki , Kawano Yukie , Ohba Takashi , Ichizuka Kiyotake , Kido Yasuhiro , Fukao Toshiyuki , Miharu Norio , Nagamatsu Takeshi , Watanabe Atsushi , Hamajima Naoki , Hirose Masaya , Sanui Ayako , Shirato Nahoko , Yotsumoto Junko , Nishiyama Miyuki , Hirose Tatsuko , Sago Haruhiko 
Published: June 2017

AbstractAimThe purpose of this study was to report the 3‐year experience of a nationwide demonstration project to introduce non‐invasive prenatal testing (NIPT) of maternal plasma for aneuploidy, and review the current status of NIPT in Japan.MethodsTests were conducted to detect aneuploidy in high‐risk pregnant women, and adequate genetic counseling was provided. The clinical data, test results, and pregnancy outcomes were recorded. We discuss the problems of NIPT on the basis of published reports and meta‐analyses.ResultsFrom April 2013 to March 2016, 30 613 tests were conducted at 55 medical sites participating in a multicenter clinical study. Among the 30 613 women tested, 554 were positive (1.81%) and 30 021 were negative (98.1%) for aneuploidy. Of the 289, 128, and 44 women who tested positive for trisomies 21, 18, and 13, respectively, and underwent definitive testing, 279 (96.5%), 106 (82.8%), and 28 (63.6%) were determined to have a true‐positive result. For the 13 481 women with negative result and whose progress could be traced, two had a false‐negative result (0.02%). The tests were performed on the condition that a standard level of genetic counseling be provided at hospitals.ConclusionHere, we report on the 3‐year nationwide experience with NIPT in Japan. It is important to establish a genetic counseling system to enable women to make informed decisions regarding prenatal testing. Moreover, a welfare system is warranted to support women who decide to give birth to and raise children with chromosomal diseases.
Racial differences in periodontal disease and 10‐year self‐reported tooth loss among late middle‐aged and older adults: the dental ARIC study
Authors: Naorungroj S. , Slade G. D. , Divaris K. , Heiss G. , Offenbacher S. , Beck J. D. 
Published: June 2017

AbstractObjectiveTo investigate racial differences in the associations between periodontitis and 10‐year self‐reported incident tooth loss in a biracial, community‐based cohort of US late middle‐aged and older adults.MethodsSubjects were 3,466 dentate men and women aged 53‐74 who underwent dental examinations from 1996 to1998. In 2012‐2013, telephone interviewers asked participants about tooth loss in the preceding 10 years. Separate multivariable ordinal logistic regression models were used to calculate proportional odds ratios (OR) and 95% confidence intervals (CI) as estimates of association between periodontitis and tooth loss for Whites and African‐Americans (AAs).ResultsThe majority of participants were White (85 percent) and female (57 percent) with 23 teeth on average at enrollment. Approximately half the Whites (56 percent) and AAs (49 percent) had periodontitis. At follow‐up, approximately 44 percent of AAs and 38 percent of Whites reported having lost ≥1 tooth. In multivariable models, severe periodontitis (OR = 3.03; 95% CI = 2.42‐3.80) and moderate periodontitis (OR = 1.64; 95% CI= 1.39‐1.94) were significant risk factors of incident tooth loss among Whites. For AAs, severe but not moderate periodontitis increased the odds of incident tooth loss (OR = 2.22; 95% CI = 1.37‐3.59). In the final model, education was inversely associated with incident tooth loss among AAs, while lower income was associated with greater odds of tooth loss among Whites.ConclusionsIn this population‐based cohort, there is racial heterogeneity in the association between periodontitis and tooth loss. Interventions to reduce the impact of periodontitis on tooth loss need to consider these differences.
Morphological integration of the kinetic skull inNatrixsnakes
Authors: Andjelković M. , Tomović L. , Ivanović A. 
Published: June 2017

AbstractMorphological integration, the covariation among phenotypic traits generated by common development and function, has been in the scope of evolutionary research for decades. As a morphological structure with complex development and various functions, the cranial skeleton represents a particularly interesting model for studies on morphological integration. However, most of the empirical investigations were done on akinetic and compact cranial skeletons of mammals. Here, we explore the pattern of integration in the extremely kinetic cranial skeleton of two closely related snake species,Natrix natrixandN. tessellata(Natricinae, Colubridae). In snakes, elements of jaws and palates on the left and right side are not spatially connected or firmly fused, allowing independent motion. Spatial independence of skeletal elements on the left and right side and their functional interconnections with extreme kinetic abilities, provide unique feeding performance in this group of tetrapods. By comparing patterns of symmetric and asymmetric components of variation we analysed cavariation patterns between kinetic and akinetic cranial elements. We tested whether the functionally and spatially connected bones are more integrated than disconnected ones and we examine impact of development and function on the morphological integration. We also explored whether and how allometry affects morphological integration in the snake's skull. Using micro‐CTscanning 3D geometric morphometrics we showed strong covariation between the braincase and elements of the feeding apparatus, and that spatially disconnected elements are not more integrated than the connected ones. We also showed that function is the main factor that generates the pattern of morphological integration, because the signal of developmental integration is very weak and probably masked by strong functional integration of skeletal elements. Allometry has a significant impact on the morphological integration, by increasing integration of the skull, particularly integration of the lower jaw bones (compound and dentary), prefrontal, palatine and quadrate with the other skeletal elements.