bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of SCAR Markers for Species Identification in the Genus Shorea (Dipterocarpaceae)
Authors: Nuroniah H. S. , Gailing O. , Finkeldey R. 
Published: October 2017

Abstract
The development of molecular markers unambiguously distinguishing groups at different taxonomic levels has numerous forensic applications. The identification of tropical timber is of particular interest in this context. We describe the development of SCAR (Sequence Characterized Amplified Region) markers for forensic applications taking the example of two closely related species of the tropical tree family Shorea (Dipterocarpaceae). Two AFLP (Amplified Fragment Length Polymorphism) fragments have been described earlier showing strong differentiation between S. leprosula and S. parvifolia. The AFLP markers were isolated from a gel, re-amplified, cloned and sequenced. Primer sets were designed from these sequences and AFLP fragments were converted into SCAR markers. The SCAR markers and PCR-RFLP markers of the chloroplast region trnLF digested with HinfI were used to screen in total 557 samples of S. parvifolia and S. leprosula from nineteen widely separated populations in Indonesia. Complete genetic differentiation between species was observed based on the putatively nuclear SCAR marker and the PCR-RFLP of the cpDNA region. We found a good agreement between leaf morphological variation and species identification based on both marker types and no indication for interspecific hybridization.
Short Note: Isolation and Characterization of Microsatellite Loci in Castanopsis fissa in Lower Subtropical China
Authors: Dong Lei , Wang Zheng-Feng , Zhu Peng , Ye Wan-Hui 
Published: October 2017

AbstractWe report on the development and characterization of ten microsatellite markers from repetitive DNA enriched libraries for Castanopsis fissa from lower subtropical China. The number of alleles ranged from three to thirteen. Observed and expected heterozygosities ranged from 0.265 to 0.818, and 0.270 to 0.873, respectively. These microsatellite markers will be used to study fine-scale spatial genetic structure of C. fissa in 20 ha Dinghushan plot in lower subtropical China.
Extramedullary Involvement of Lymph Nodes in Multiple Myeloma
Authors: Todorovic Zeljko , Jovanovic Milena , Todorovic Dusan , Ivosevic Anita , Markovic Marina , Radovanovic Drakce , Jovanovic Danijela , Cemerikic Vesna , Djurdjevic Predrag 
Published: October 2017

Abstract
Myeloma multiplex is a malignant disease of bone marrow plasma cells. It is usually confined to the bone marrow, but in rare cases, patients can develop extramedullary disease. The involvement of lymph nodes is rare and can be a diagnostic challenge. Here, we describe a 36-year-old male patient who presented with abdominal pain and discomfort initially. An abdominal ultrasound followed by computed tomography (CT) revealed retroperitoneal and mesenteric lymph node enlargement. Biopsies of the abdominal lymph node and infiltrated colon showed a plasma cell infiltrate positive for CD79α, CD38, CD138, kappa light chain and VEGF2. Multiple myeloma with extramedullary localization was diagnosed. After six cycles of chemotherapy consisting of doxorubicin, dexamethasone and thalidomide followed by autologous haematopoietic cell transplantation, the patient achieved complete remission. Specifically, a CT scan after therapy showed enlarged lymph nodes in the abdomen, but PET CT scans did not detect any metabolically active foci. Thee years after the completion of therapy, the patient remains in remission. This case illustrates a rare presentation of extramedullary myeloma involving the abdominal lymph nodes, which could have been potentially mistaken for a lymphoid malignancy.
Toxic Effects of Metallopharmaceuticals
Authors: Novokmet Slobodan , Stojic Isidora , Radonjic Katarina , Savic Maja , Jeremic Jovana 
Published: October 2017

Abstract
Discovery of the metallopharmaceutical cisplatin and its use in antitumour therapy has initiated the rational design and screening of metal-based anticancer agents as potential chemotherapeutics. In addition to the achievements of cisplatin and its therapeutic analogues, there are significant drawbacks to its use: resistance and toxicity. Over the past four decades, numerous transition metal complexes have been synthesized and investigated in vitro and in vivo. The most studied metals among these complexes are platinum and ruthenium. The key features of these investigations is to find novel metal complexes that could potentially exert less toxicity and equal or higher antitumour potency and to overcome other pharmacological deficiencies. Ru complexes have a different mode of action than cisplatin does, some of which are under clinical trials for treating metastatic or cisplatin-resistant tumours. This review consists of the current knowledge, published and unpublished, related to the toxicity of metallopharmaceuticals, and special attention is given to platinum [Pt(II) and Pt(IV)] and ruthenium [Ru(II) and Ru(III)] complexes.
Spontaneous Subcapsular Renal Hematoma as a Complication of Acute Pyelonephritis: A Case Report
Authors: Jankovic Ivan , Nikolic Tomislav , Mitrovic Slobodanka , Vojinovic Radisa 
Published: October 2017

Abstract
Spontaneous subcapsular renal hematoma (SSRH) emerged as a complication of acute pyelonephritis (APN) is an extremely rare condition. We showed a patient aged 63 years hospitalized due to languor, febrility, abdominal pain accompanied by nausea and vomiting. Ultrasound (US) examination of the abdomen and multidetector computed tomography (MDCT) showed the presence of subcapsular hematoma of the left kidney with calculus in the initial part of the left ureter. Laboratory tests registered a positive inflammation syndrome, anemia and an increase in nitrogen compounds. Based on laboratory results, clinical presentation and imaging techniques it has been found that it is APN with spontaneous subcapsular hematoma. After application of non-surgical treatment which included antibiotic therapy with percutaneous drainage of hematoma, a good clinical response with regression of subjective symptoms and hematoma was obtained. On repeated US and MDCT after 18 months no pathological changes in the kidneys were registered. Spontaneous subcapsular hematoma extremely rare occurs as a result of APN associated with calculosis. The use of non-surgical treatment, which includes appropriate antibiotic therapy with percutaneous drainage of hematoma would represent a method of first choice.
Conversación entre Eulàlia Valldosera y Amparo Lozano
Authors: Lozano Amparo 
Published: October 2017

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p class="p1">Eulàlia Valldosera (1963) es una artista española que trabaja con distintos medios como la performance, la instalación y el vídeo. A través de ellos reflexiona en torno al cuerpo femenino, la cotidianeidad y la intimidad. En esta conversación que tuvo lugar en octubre de 2016 con la crítica y comisaria de exposiciones Amparo Lozano, conversa sobre su trayectoria artística, centrándose en sus proyectos performativos y expresando sus opiniones sobre otros temas como el contexto español después de la Transición y el panorama del arte contemporáneo.</p><p class="p1"> </p></div></div></div>
Comprar, vender, comer: o consumo da carne e os circuitos mercantis e sociais em São Paulo; 1852-1927
Authors: Lanna Ana Lucia Duarte 
Published: October 2017

A cidade de São Paulo foi, pelo menos desde o século XVIII, importante núcleo urbano, articulador dos processos de interiorização e ocupação do território. A carne sempre integrou a dieta alimentar dos paulistas, de todos os grupos sociais, sendo um tema sensível como atividade econômica ou prática socia.A expansão da cidade não altera o regime alimentar que continuará definido pelo uso cotidiano do feijão, da carne e da farinha. As presenças estrangeiras ampliarão as possibilidades e demandas alimentares, como por exemplo a introdução e generalização do consumo de diversos tipos de pasta e verduras mas, os de fora, incorporarão as tradições alimentares paulistas.Desde inícios do século XIX a municipalidade procurava regrar o comércio de carne na cidade seja pelo controle daquilo que era comerciado seja pelo controle das reses destinadas ao abate e ainda pela construção de matadouros. Estes inseriam-se nas políticas públicas de ordenamento do espaço.Reformas, ampliações e deslocamentos marcam as trajetórias deste equipamento no espaço da cidade. Questões sanitárias e de controle alimentar incidiram sobre os matadouros analisados mas sobre eles sempre incidiram as noções de sujeira, doença e descarte. Melhoramento urbano necessário e indesejável foi sempre relegado para as franjas da cidade.
Ak-Anonymous Rule Clustering Approach for Data Publishing
Authors: Ohki Motoyuki ,   Osaka University 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan, Inuiguchi Masahiro 
Published: October 2017

Classification rules should be open for public inspection to ensure fairness.These rules can be originally induced from some dataset. If induced classification rules are supported only by a small number of objects in the dataset, publication can lead to identification of objects supporting the rule, given their speciality. Eventually, it is possible to retrieve information about the identified objects. This identifiability is not desirable in terms of data privacy.In this paper, to avoid such privacy breaches, we propose rule clustering for achievingk-anonymity of all induced rules, i.e., the induced rules are supported by at leastkobjects in the dataset. The proposed approach merges similar rules to satisfyk-anonymity while aiming to maintain the classification accuracy. Two numerical experiments were executed to verify both the accuracy of the classifier with the rules obtained by the proposed method and the ratio of decision classes revealed from leaked information about objects. The experimental results show the usefulness of the proposed method.
Entrepreneurial Marketing and New Venture Performance: The Mediating Effects of Ambidextrous Innovation
Authors: Hu Xiaowen ,   School of Economics and Management, Anhui Normal University Huajin South Road 189, Wuhu 241002, Anhui, China, Zhu Lidong , Zhang Hui 
Published: October 2017

Entrepreneurial Marketing has a significant effect on new ventures’ performance. However, the findings have been mixed and conflicting. There is still little in-depth exploration of its specific working mechanism based on two distinct literatures streams from ambidextrous innovation and entrepreneurial marketing. We present an integrated framework for analyzing entrepreneurial marketing, ambidextrous innovation and new venture performance (NVP). By conducting an empirical studyon a sample of 883 new ventures (NVs) in Anhui province in China, the study found that: (a) EM is an important driver of NVP and only five dimensions of EM have positively effects on NVP ,including proactiveness, opportunity-focus, innovations, risk-taking and resource leveraging. (b) Both exploration innovation and exploitation innovation advance NVP. (c) The ambidextrous innovation did not affect NVP significantly. (d) Exploration innovation and exploitation innovation partly mediate the relationship between EM and NVP.
Machine-Code Program Evolution by Genetic Programming Using Asynchronous Reference-Based Evaluation Through Single-Event Upset in On-Board Computer
Authors: Harada Tomohiro , Takadama Keiki ,   College of Information Science and Engineering, Ritsumeikan University 1-1-1 Noji-Higashi, Kusatsu, Shiga 525-8577, Japan,   Department of Informatics, The University of Electro-Communications 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan
Published: October 2017

This study proposes a novel genetic programming method using asynchronous reference-based evaluation (called AREGP) to evolve computer programs through single-event upsets (SEUs) in the on-board computer in space missions.	AREGP is an extension of Tierra-based asynchronous genetic programming (TAGP), which was proposed in our previous study.	It is based on the idea of the biological simulator, Tierra, where digital creatures are evolved through bit inversions in a program.	AREGP not only inherits the advantages of TAGP but also overcomes its limitation, i.e., TAGP cannot select good programs for evolution without an appropriate threshold.	Specifically, AREGP introduces an archive mechanism to maintain good programs and a reference-based evaluation by using the archive for appropriate threshold selection and removal.	To investigate the effectiveness of the proposed AREGP, simulation experiments are performed to evolve the assembly language program in the SEU environment.	In these experiments, the PIC instruction set, which is carried on many types of spacecraft, is used as the evolved assembly program.	The experimental results revealed that AREGP cannot only maintain the correct program through SEU with high occurrence rate, but is also better at reducing the size of programs in comparison with TAGP.	Additionally, AREGP can achieve a shorter execution step and smaller size of programs, which cannot be achieved by TAGP.
Why do water points fail? Learning from open-ended failure descriptions in the WPDx dataset
Authors: Cook Joseph , Lahren Sheena 
Published: October 2017

Abstract
Despite the explosion of geospatial data collected on water points, there have been relatively few efforts to date to use these data to understand the correlates and potential causes of water point breakdowns. We add to this literature by coding open-ended responses around functionality status in the open-access WPDx (Water Point Data Exchange) database. We code responses into 41 different categories of functionality problems for 244,075 water points from 25 countries in Africa, Asia and Central America, though we narrow our analysis to 41,716 points in six countries. We find that descriptions of technical breakdowns or problems are most common, though concerns about water resources and water quality feature prominently. We also find that 7% of records in our analysis subset spontaneously mention concerns over vandalism or theft, something which has received relatively little attention in the sector. Information on user financial contributions is mostly omitted by uploaders to WPDx, but we find that users are not contributing at all in 40% of the 96,651 water points with these data. Our results should be interpreted cautiously considering the obvious selection and subjectivity concerns, but the analysis highlights the potential benefits of coordinating an augmented data collection standard.
Viruses in the environment – presence and diversity of bacteriophage and enteric virus populations in the Umhlangane River, Durban, South Africa
Authors: Marie Veronna , Lin Johnson 
Published: October 2017

Abstract
Due to the continued persistence of waterborne viral-associated infections, the presence of enteric viruses is a concern. Notwithstanding the health implications, viral diversity and abundance is an indicator of water quality declination in the environment. The aim of this study was to evaluate the presence of viruses (bacteriophage and enteric viruses) in a highly polluted, anthropogenic-influenced river system over a 6-month period at five sampling points. Cytopathic-based tissue culture assays revealed that the isolated viruses were infectious when tested on Hep-G2, HEK293 and Vero cells. While transmission electron microscopy (TEM) revealed that the majority of the viruses were bacteriophages, a number of presumptive enteric virus families were visualized, some of which include Picornaviridae, Adenoviridae, Polyomaviridae and Reoviridae. Finally, primer specific nested polymerase chain reaction (nested-PCR)/reverse transcription-polymerase chain reaction (RT-PCR) coupled with BLAST analysis identified human adenovirus, polyomavirus and hepatitis A and C virus genomes in river water samples. Taken together, the complexity of both bacteriophage and enteric virus populations in the river has potential health implications. Finally, a systematic integrated risk assessment and management plan to identify and minimize sources of faecal contamination is the most effective way of ensuring water safety and should be established in all future guidelines.
Power and policy in floodplain management, drawing on research in Alberta, Canada
Authors: Self Julie , Penning-Rowsell Edmund 
Published: October 2017

AbstractFloodplain management policy (FMP) implementation and change involve a range of actors and opportunities for power to be exercised. Considering four different conceptualizations of power, this paper explores the actors and instances where power emerges in FMP implementation and change, using Alberta, Canada, as our focus. We consider which conceptualization is most reflective of the Alberta context. We conclude that all four views of behaviour are relevant here, with some power dynamics between actors more complex than others. Further, these dynamics change over time, and therefore the trade-offs to be made also change. Understanding power relations allows for clearer identification of these trade-offs and, therefore, the potential winners and losers in FMP. We describe strategies for assisting in this process of managing power relations, including information sharing, transparency and actively managing the policy process.
Health Care Costs Associated with AKI
Authors: Collister David , Pannu Neesh , Ye Feng , James Matthew , Hemmelgarn Brenda , Chui Betty , Manns Braden , Klarenbach Scott ,   on behalf of the Alberta Kidney Disease Network
Published: October 2017

Background and objectives
An understanding of the health care resource use associated with AKI is needed to frame the investment and cost-effectiveness of strategies to prevent AKI and promote kidney recovery.

Design, setting, participants, & measurements
We assembled population-based cohort of adults hospitalized in Alberta between November of 2002 and March of 2009 without ESRD or an eGFR<15 ml/min per 1.73 m2. Outpatient serum creatinine measurements 6 months preceding admission defined baseline kidney function, and serum creatinine during the first 14 days of hospitalization defined Acute Kidney Injury Network stage; kidney recovery defined as serum creatinine within 25% of baseline and independence from dialysis was assessed at 90 days after AKI. Health care utilization and costs (in 2015 Canadian dollars) were determined from inpatient, outpatient, and physician claims datasets during the index hospitalization, recovery period (90 days post-AKI assessment), and 3–12 months post-AKI. A fully adjusted generalized linear model regression analysis was used to estimate costs associated with AKI.

Results
Of 239,906 hospitalized subjects, 25,495 (10.6%), 4598 (1.9%), 2493 (1.0%), and 670 (0.3%) had Acute Kidney Injury Network stages 1, 2, 3 without dialysis, and 3 with dialysis, respectively. Greater severity of AKI was associated with incremental increases in length of stay (+2.8; 95% confidence interval, 1.4 to 4.3 to +7.4; 95% confidence interval, 7.2 to 7.5 days) and costs (+$3779; 95% confidence interval, $3555 to $4004 to +$18,291; 95% confidence interval, $15,573 to $21,009 Canadian dollars) from admission to recovery assessment (3 months). At months 3–12 postadmission, compared with subjects without AKI, AKI with kidney recovery and AKI without kidney recovery were associated with incremental costs of +$2912–$3231 and +$6035–$8563 Canadian dollars, respectively. The estimated incremental cost of AKI in Canada is estimated to be over $200 million Canadian dollars per year.

Conclusions
Severity of AKI, need for dialysis, and lack of kidney recovery are associated with significant health care costs in hospitalized patients and persist a year after admission. Strategies to identify, prevent, and facilitate kidney recovery are needed.
Metformin Use May Moderate the Effect of DPP-4 Inhibitors on Cardiovascular Outcomes
Authors: Crowley Matthew J. , Williams John W. , Kosinski Andrzej S. , D’Alessio David A. , Buse John B. 
Published: October 2017

OBJECTIVE
To explore prevalent metformin use as a potential moderator of the cardiovascular effects of dipeptidyl peptidase 4 inhibitors (DPP-4i).

RESEARCH DESIGN AND METHODS
We performed a meta-analysis of the three major cardiovascular outcomes trials examining DPP-4i. We used meta-regression to examine how the cardiovascular effects of DPP-4i differ between prevalent metformin users and baseline nonusers.

RESULTS
While prevalent metformin users experienced a trend toward improved cardiovascular outcomes with DPP-4i (summary hazard ratio [HR] 0.92 [95% CI 0.84, 1.01]), baseline metformin nonusers showed a trend toward harm (HR 1.10 [95% CI 0.97, 1.26]). The difference in overall DPP-4i effect between metformin user and nonuser subgroups was statistically significant (P = 0.036).

CONCLUSIONS
Baseline metformin status may have a moderating effect on cardiovascular outcomes with DPP-4i use. This hypothesis-generating analysis suggests there is residual uncertainty as to how DPP-4i affect cardiovascular outcomes, depending on concurrently prescribed medications.
Kotitori: integroitu palveluohjausmalli yksityisen ja julkisen rajalla
Authors: Karsio Olli Veli-Pekka , Tynkkynen Liina-Kaisa 
Published: October 2017

Sosiaali- ja terveyspalveluiden kentältä on mahdollista tunnistaa entistä enemmän toimijoita ja palveluita, joihin perinteiset yksityisen tai julkisen määritelmät eivät enää sovi. Yksi esimerkki tämän kaltaisesta palvelusta on Tampereella vuonna 2009 aloittanut vanhojen ihmisten kotihoidon palveluohjauksesta ja palveluintegraatiosta vastaava Kotitori. Tutkimuskysymyksemme on, millainen palveluintegraation ja -ohjauksen muoto Kotitori on? Erityisesti kysymme, mitä tavoitteita Kotitorin perustamiseen liitettiin, sekä miten julkisen ja yksityisten toimijoiden tehtävät ja niiden väliset suhteet määrittyvät Kotitorin toiminnassa. Vastaamme tutkimuskysymyksiin analysoimalla Kotitorin perustamisasiakirjoja ja palvelun perustamisessa ja aloittamisessa keskeisesti vaikuttaneiden toimijoiden haastatteluita. Kotitorin toiminnassa julkisen ja yksityisen palvelun rajat ja tehtävät määritellään uudelleen. Se edustaa uudentyyppistä julkisrahoitteista palvelua, jossa yksityisen ja julkisen rajat sekoittuvat.
Kotitori: Service integrator and case management model in between the public and private sectors
Kotitori service integrator is a publicly funded, but privately produced service in the field of eldercare services. It is responsible for case management and service integration of homecare services for the elderly. It started in 2009 in the city of Tampere in Finland. It aims to combine the resources of public and private sectors to better meet the needs of elderly service users. We study in this article, what kind of service integration and case management service Kotitori is. Firstly, we ask, what goals were included in the foundation of the service integrator model. Secondly, how are the tasks and relations between public and private actors defined in Kotitori service model? The research data consists of interviews and municipal documents concerning the foundation of Kotitori service integrator model. We conclude that Kotitori represents a novel service integrator and case management service, in which the tasks and relations between public and private sectors are redefined.