bluuebunny/crossref_metadata_2025_split huggingface dataset:
To fail is human: remediating remediation in medical education
Authors: Kalet Adina , Chou Calvin L. , Ellaway Rachel H. 
Published: October 2017

Introduction Remediating failing medical learners has traditionally been a craft activity responding to individual learner and remediator circumstances. Although there have been moves towards more systematic approaches to remediation (at least at the institutional level), these changes have tended to focus on due process and defensibility rather than on educational principles. As remediation practice evolves, there is a growing need for common theoretical and systems-based perspectives to guide this work.
Methods This paper steps back from the practicalities of remediation practice to take a critical systems perspective on remediation in contemporary medical education. In doing so, the authors acknowledge the complex interactions between institutional, professional, and societal forces that are both facilitators of and barriers to effective remediation practices.
Results The authors propose a model that situates remediation within the contexts of society as a whole, the medical profession, and medical education institutions. They also outline a number of recommendations to constructively align remediation principles and practices, support a continuum of remediation practices, destigmatize remediation, and develop institutional communities of practice in remediation.
Discussion Medical educators must embrace a responsible and accountable systems-level approach to remediation if they are to meet their obligations to provide a safe and effective physician workforce.
Prevalence of attention deficit hyperactivity disorder among primary school-children in Riyadh, Saudi Arabia; 2015-2016
Authors: Albatti Turki H. , Alhedyan Zhour , Alnaeim Norah , Almuhareb Anjod , Alabdulkarim Jawaher , Albadia Rawan , Alshahrani Khawla 
Published: October 2017

Objectives:
The aim of the study was to 1) determine the prevalence of Attention Deficit Hyperactivity Disorder (ADHD) among both governmental and private primary Saudi school children, 2) measure the gender difference of ADHD prevalence, and 3) determine any association between the sociodemographic characteristic of the parents of children with ADHD.

Methods:
This is an observational cross-sectional study of 1000 primary school children belonging to 1st, 2nd and 3rd grade. The selected students were screened by the ADHD rating scale using multistage sampling technique. The first stage was selection of 20 schools from all Riyadh regions by simple randomization. The second stage was choosing children whom serial numbers were multiples of five in each class. The ADHD rating scale was filled by both parents and teachers along with a sociodemographic questionnaire for the parents.

Results:
The estimated prevalence of ADHD was 3.4%. ADHD manifestations affect boys more than girls. In addition, ADHD was more frequent among children of illiterate mothers. Finally, ADHD was significantly more prevalent among first grade children.

Conclusion:
This epidemiological study filled the data gap of ADHD prevalence in Riyadh. The study's findings go in line with many nearby and global studies.
Fish-borne nematodiases in South America: neglected emerging diseases
Authors: Eiras J.C. , Pavanelli G.C. , Takemoto R.M. , Nawa Y. 
Published: October 2017

AbstractFish-borne zoonotic nematodes may infect humans when fish or squid are ingested raw or inadequately cooked. Human infections may have serious consequences, including the unexpected deaths of infected people. This kind of disease is poorly known in general, and the characteristics of such infections in South American countries as a whole have never been assessed. In this paper the present status of fish-borne nematodiases in humans in South American countries is characterized. Potentially zoonotic nematode species are very common in both freshwater and marine fish in South America. Reports of human infections have only been found in some countries, and their incidence (especially with anisakids andGnathostomaspp.) varies from country to country. Apparently they are more abundant in countries with strong traditions of eating raw fish, and are more frequent on the western coast of South America. So far fish-borne nematodes have been reported in Argentina, Brazil, Chile, Colombia, Ecuador and Peru. In recent years, cases of human infection have appeared in probably underestimated numbers. People need to be clearly informed about risky feeding habits, and physicians need to learn more about zoonotic diseases.
Declines in prevalence of adolescent substance use disorders and delinquent behaviors in the USA: a unitary trend?
Authors: Grucza R. A. , Krueger R. F. , Agrawal Arpana , Plunk A. D. , Krauss M. J. , Bongu J. , Cavazos-Rehg P. A. , Bierut L. J. 
Published: October 2017

AbstractBackgroundDownward trends in a number of adolescent risk behaviors including violence, crime, and drug use have been observed in the USA in recent years. It is unknown whether these are separate trends or whether they might relate to a general reduction in propensity to engage in such behaviors. Our objectives were to quantify trends in substance use disorders (SUDs) and delinquent behaviors over the 2003–2014 period and to determine whether they might reflect a single trend in an Externalizing-like trait.MethodsWe analyzed data from 12 to 17 year old participants from the National Survey on Drug Use and Health, a representative survey of the household dwelling population of the USA, across the 2003–2014 period (N = 210 599). Outcomes included past-year prevalence of six categories of substance use disorder and six categories of delinquent behavior.ResultsTrend analysis suggested a net decline of 49% in mean number of SUDs and a 34% decline in delinquent behaviors over the 12-year period. Item Response Theory models were consistent with the interpretation that declines in each set of outcomes could be attributed to changes in mean levels of a latent, Externalizing-like trait.ConclusionsOur findings suggest that declines in SUDs and some delinquent behaviors reflect a single trend related to an Externalizing-like trait. Identifying the factors contributing to this trend may facilitate continued improvement across a spectrum of adolescent risk behaviors.
Making replication mainstream
Authors: Zwaan Rolf A. , Etz Alexander , Lucas Richard E. , Donnellan M. Brent 
Published: October 2017

AbstractMany philosophers of science and methodologists have argued that the ability to repeat studies and obtain similar results is an essential component of science. A finding is elevated from single observation to scientific evidence when the procedures that were used to obtain it can be reproduced and the finding itself can be replicated. Recent replication attempts show that some high profile results – most notably in psychology, but in many other disciplines as well – cannot be replicated consistently. These replication attempts have generated a considerable amount of controversy, and the issue of whether direct replications have value has, in particular, proven to be contentious. However, much of this discussion has occurred in published commentaries and social media outlets, resulting in a fragmented discourse. To address the need for an integrative summary, we review various types of replication studies and then discuss the most commonly voiced concerns about direct replication. We provide detailed responses to these concerns and consider different statistical ways to evaluate replications. We conclude there are no theoretical or statistical obstacles to making direct replication a routine aspect of psychological science.
Women, wars, and world affairs: Recovering feminist International Relations, 1915–39
Authors: Stöckmann Jan 
Published: October 2017

AbstractThe academic study of International Relations (IR) emerged in the context of transnational networks of scholars, diplomats, politicians, and activists. Contrary to conventional wisdom, women belonged to these networks in various capacities and, crucially, contributed to the intellectual formation of the discipline. Whether as members of pressure groups, such as the Women’s International League for Peace and Freedom (WILPF), as independent authors or academics, they discussed all major issues of IR. Drawing on a range of international authors – including Anna B. Eckstein, Agnes Headlam-Morley, Lucy Mair, Margery Perham, Helena Swanwick, and Louise Weiss – this article recovers the intellectual substance of their work, arguing that it constitutes a genuinely feminist approach to IR. Early feminist IR authors emphasised the interests of women, children, and other marginalised groups, they demanded female representation in government and diplomacy, they condemned imperialism and racism, opposed military capitalism, employed religious, emotional, and universalist rhetoric, and advocated the role of education. Despite widespread male domination, women taught at universities, published in academic journals, spoke at conferences, and organised international summer schools. This article explores the origins of feminist IR scholarship and contextualises this body of thought within the revisionist history of IR.
A connectomic approach to the lateral geniculate nucleus
Authors: MORGAN JOSH L. 
Published: October 2017

AbstractAlthough the core functions and structure of the lateral geniculate nucleus (LGN) are well understood, this core is surrounded by questions about the integration of feedforward and feedback connections, interactions between different channels of information, and how activity dependent development restructures synaptic networks. Our understanding of the organization of the mouse LGN is particularly limited given how important it has become as a model system. Advances in circuit scale electron microscopy (cellular connectomics) have made it possible to reconstruct the synaptic connectivity of hundreds of neurons within in a circuit the size of the mouse LGN. These circuit reconstructions can reveal cell type-to-cell type canonical wiring diagrams as well as the higher order wiring motifs that are only visible in reconstructions of intact networks. Connectomic analysis of the LGN therefore not only can answer longstanding questions about the organization of the visual thalamus but also presents unique opportunities for investigating fundamental properties of mammalian circuit formation.
RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
Authors: Jin Ting , Lavoie Hugo , Sahmi Malha , David Maud , Hilt Christine , Hammell Amy , Therrien Marc 
Published: October 2017

AbstractFirst-generation RAF inhibitors paradoxically induce ERK signaling in normal and tumor cells exhibiting RAS activity. Compound-induced RAF dimerization through stabilization of the RAF ON/active state by inhibitors has emerged as a critical contributing factor. RAF inhibitors also enhance RAS−RAF association. Although this event is thought to play a key role in priming RAF activation, the underlying mechanism is not known. Here we report that RAF inhibitors induce the disruption of intramolecular interactions between the kinase domain and its N-terminal regulatory region independently of RAS activity. This provides a molecular basis to explain the induction of RAS−RAF association by RAF inhibitors, as well as the co-operativity observed between RAS activity and RAF kinase inhibitors in driving RAF activation. Profiling of second-generation RAF inhibitors confirmed their improved mode of action, but also revealed liabilities that allowed us to discern two properties of an ideal RAF inhibitor: high-binding affinity to all RAF paralogs and maintenance of the OFF/autoinhibited state of the enzyme.
Homeostatic plasticity shapes the visual system’s first synapse
Authors: Johnson Robert E. , Tien Nai-Wen , Shen Ning , Pearson James T. , Soto Florentina , Kerschensteiner Daniel 
Published: October 2017

AbstractVision in dim light depends on synapses between rods and rod bipolar cells (RBCs). Here, we find that these synapses exist in multiple configurations, in which single release sites of rods are apposed by one to three postsynaptic densities (PSDs). Single RBCs often form multiple PSDs with one rod; and neighboring RBCs share ~13% of their inputs. Rod-RBC synapses develop while ~7% of RBCs undergo programmed cell death (PCD). Although PCD is common throughout the nervous system, its influences on circuit development and function are not well understood. We generate mice in which ~53 and ~93% of RBCs, respectively, are removed during development. In these mice, dendrites of the remaining RBCs expand in graded fashion independent of light-evoked input. As RBC dendrites expand, they form fewer multi-PSD contacts with rods. Electrophysiological recordings indicate that this homeostatic co-regulation of neurite and synapse development preserves retinal function in dim light.
Physiological and transcriptome response to cadmium in cosmos (Cosmos bipinnatus Cav.) seedlings
Authors: Liu Yujing , Yu Xiaofang , Feng Yimei , Zhang Chao , Wang Chao , Zeng Jian , Huang Zhuo , Kang Houyang , Fan Xing , Sha Lina , Zhang Haiqin , Zhou Yonghong , Gao Suping , Chen Qibing 
Published: October 2017

AbstractTo date, several species of Asteraceae have been considered as Cd-accumulators. However, little information on the Cd tolerance and associated mechanisms of Asteraceae species Cosmos bipinnatus, is known. Presently, several physiological indexes and transcriptome profiling under Cd stress were investigated. C. bipinnatus exhibited strong Cd tolerance and recommended as a Cd-accumulator, although the biomasses were reduced by Cd. Meanwhile, Cd stresses reduced Zn and Ca uptake, but increased Fe uptake. Subcellular distribution indicated that the vacuole sequestration in root mainly detoxified Cd under lower Cd stress. Whilst, cell wall binding and vacuole sequestration in root co-detoxified Cd under high Cd exposure. Meanwhile, 66,407 unigenes were assembled and 41,674 (62.75%) unigenes were annotated in at least one database. 2,658 DEGs including 1,292 up-regulated unigenes and 1,366 down-regulated unigenes were identified under 40 μmol/L Cd stress. Among of these DEGs, ZIPs, HMAs, NRAMPs and ABC transporters might participate in Cd uptake, translocation and accumulation. Many DEGs participating in several processes such as cell wall biosynthesis, GSH metabolism, TCA cycle and antioxidant system probably play critical roles in cell wall binding, vacuole sequestration and detoxification. These results provided a novel insight into the physiological and transcriptome response to Cd in C. bipinnatus seedlings.
Combined Application of Bacterial Predation and Violacein to Kill Polymicrobial Pathogenic Communities
Authors: Im Hansol , Choi Seong Yeol , Son Sangmo , Mitchell Robert J. 
Published: October 2017

AbstractViolacein is a bisindole antibiotic that is effective against Gram-positive bacteria while the bacterial predator, Bdellovibrio bacteriovorus HD100, predates on Gram-negative strains. In this study, we evaluated the use of both together against multidrug resistant pathogens. The two antibacterial agents did not antagonize the activity of the other. For example, treatment of Staphylococcus aureus with violacein reduced its viability by more than 2,000-fold with or without B. bacteriovorus addition. Likewise, predation of Acinetobacter baumannii reduced the viability of this pathogen by more than 13,000-fold, regardless if violacein was present or not. When used individually against mixed bacterial cultures containing both Gram-positive and Gram-negative strains, violacein and B. bacteriovorus HD100 were effective against only their respective strains. The combined application of both violacein and B. bacteriovorus HD100, however, reduced the total pathogen numbers by as much as 84,500-fold. Their combined effectiveness was also demonstrated using a 4-species culture containing S. aureus, A. baumannii, Bacillus cereus and Klebsiella pneumoniae. When used alone, violacein and bacterial predation reduced the total population by only 19% and 68%, respectively. In conjunction with each other, the pathogen viability was reduced by 2,965-fold (99.98%), illustrating the prospective use of these two antimicrobials together against mixed species populations.
Producing Coral Offspring with Cryopreserved Sperm: A Tool for Coral Reef Restoration
Authors: Hagedorn Mary , Carter Virginia L. , Henley E. Michael , van Oppen Madeleine J. H. , Hobbs Rebecca , Spindler Rebecca E. 
Published: October 2017

AbstractCryopreservation is an important conservation tool, which may help reef-building coral survive. However, scaling-up from small, laboratory-sized experiments to higher-throughput restoration is a major challenge. To be an effective restoration tool, the cryopreservation methods and husbandry to produce new offspring must be defined. This study examined small and larger-scale in vitro reproduction and settlement for Acropora tenuis and Acropora millepora and found that: 1) cryopreservation of coral sperm reduced sperm motility and fertilization success in half, thus fresh sperm, capable of becoming highly motile, is key; 2) the sperm-to-egg ratio and the concentration of the cryoprotectant treatments affected fertilization success in small- and larger-scale reproduction trials using cryopreserved sperm (p < 0.05); 3) cryopreservation did not affect settlement success, as larvae produced with fresh or cryopreserved sperm had the same settlement success (p > 0.05); and 4) the residence time of the sperm within the bank was not important as the fertilization success of sperm frozen for less than 1 month was similar to that frozen up to 2 years (p > 0.05). These results described the first settlement for coral larvae produced from cryopreserved sperm and established important ground-work principles for the use of cryopreserved coral sperm for future reef restoration efforts.
Imaging the Creative Unconscious: Reflexive Neural Responses to Objects in the Visual and Parahippocampal Region Predicts State and Trait Creativity
Authors: Friis-Olivarius Morten , Hulme Oliver J. , Skov Martin , Ramsøy Thomas Z. , Siebner Hartwig R. 
Published: October 2017

AbstractWhat does it take to have a creative mind? Theories of creative cognition assert that the quantity of automatic associations places fundamental constraints on the probability of reaching creative solutions. Due to the difficulties inherent in isolating automated associative responses from cognitive control, the neural basis underlying this faculty remains unknown. Here we acquired fMRI data in an incidental-viewing paradigm in which subjects performed an attention-demanding task whilst viewing task-irrelevant objects. By assigning a standard creativity task on the same objects out of the scanner, as well as a battery of psychometric creativity tests, we could assess whether stimulus-bound neural activity was predictive of state or trait variability in creativity. We found that stimulus-bound responses in superior occipital regions were linearly predictive of trial-by-trial variability in creative performance (state-creativity), and that in more creative individuals (trait-creativity) this response was more strongly expressed in entorhinal cortex. Additionally, the mean response to the onset of objects in parahippocampal gyrus was predictive of trait differences in creativity. This work suggests that, creative individuals are endowed with occipital and medial temporal reflexes that generate a greater fluency in associative representations, making them more accessible for ideation even when no ideation is explicitly called for.
Direct separation of minor actinides from high level liquid waste by Me
2

-CA-BTP/SiO2-P adsorbent
Authors: Ning Shun Yan , Wang Xin Peng , Zou Qing , Shi Wei Qun , Tang Fang Dong , He Lin Feng , Wei Yue Zhou 
Published: October 2017

AbstractDirectly separating minor actinides (MA: Am, Cm, etc.) from high level liquid waste (HLLW) containing lanthanides and other fission products is of great significance for the whole nuclear fuel cycle, especially in the aspects of reducing long-term radioactivity and simplifying the post-processing separation process. Herein, a novel silica-based adsorbent Me2-CA-BTP/SiO2-P was prepared by impregnating Me2-CA-BTP (2,6-bis(5,6,7,8-tetrahydro-5,8,9,9-tetramethyl-5,8-methano-1,2,4-benzotriazin-3-yl)pyridine) into porous silica/polymer support particles (SiO2-P) under reduced pressure. It was found Me2-CA-BTP/SiO2-P exhibited good adsorption selectivity towards 241Am(III) over 152Eu(III) in a wide nitric acid range, acceptable adsorption kinetic, adequate stability against γ irradiation in 1 and 3 M HNO3 solutions, and successfully separated 241Am(III) from simulated 3 M HNO3 HLLW. In sum, considering the good overall performance of Me2-CA-BTP/SiO2-P adsorbent, it has great application potential for directly separating MA from HLLW, and is expected to establish an advanced simplified MA separation process, which is very meaningful for the development of nuclear energy.
Salinity stratification controlled productivity variation over 300 ky in the Bay of Bengal
Authors: Da Silva R. , Mazumdar A. , Mapder T. , Peketi A. , Joshi R. K. , Shaji A. , Mahalakshmi P. , Sawant B. , Naik B. G. , Carvalho M. A. , Molletti S. K. 
Published: October 2017

AbstractThe unique hydrographic setting of the Bay of Bengal (BoB) makes it an ideal tropical marine system to study the influence of regional and global forcings on productivity and [CO2aq] through the late quaternary. Enormous fresh water flux into the BoB and consequent salinity stratification significantly weaken the convective mixing and wind driven processes which are commonly responsible for transport of nutrients to the euphotic zone driving primary productivity. Here we present a high resolution organic carbon-CaCO3 MAR and δ13CTOC records for the last 300 ky from the BoB. The results show significant productivity variation at marine isotope sub-stages and millennial timescales. Colder sub-stages and stadials (Dansgard-Oeschger cycle) show a boost in productivity which may be attributed to thinning of low salinity cap, thereby facilitating efficient nutrient transport across the euphotic zone by the combination of wind driven processes (entrainment and upwelling), convective mixing and cold core eddies. The [CO2aq] was a net result of global pCO2 variation and regional processes. Our long term high-resolution data indicates a possibility of marked change in productivity/biogeochemistry of BOB in the future due to global warming, thus affecting the coastal economy.