bluuebunny/crossref_metadata_2025_split huggingface dataset:
International research priorities for integrated care and cross-boundary working: an electronic Delphi study
Authors: Scott Jason , Waring Justin , Abuosi Aaron Asibi , Agada-Amade Yakubu Adole , Bashar Jibril Muhammad , De Brún Aoife , Cann Henry , Crowley Philip , Dewa Lindsay H , Spanos Samantha , Wiig Siri 
Published: September 2024

Abstract

Background
Integrated care can be broadly defined as the delivery of high-quality and safe care for patients as they cross organizational boundaries or when care is delivered with multiple health care teams, professions, or organizations. Successful integration of care services is contingent on multiple and complex factors across macro, meso, and micro levels of health and social care systems in lower-, middle-, and higher-income countries. Previous priorities for the future development of integrated care have focused on designing and implementing models or approaches to integrated care rather than establishing the research needed to underpin them. This study aimed to address this evidence gap by developing a consensus on international research priorities related to integration of care and cross-boundary working.

Methods
We conducted a sequential electronic Delphi (eDelphi) study from September 2023 to December 2023. The eDelphi process consisted of initial priority generation followed by two rounds of consensus development via an online survey. Sixty-six priorities were generated by 19 delegates at an international conference workshop titled, ‘Priority setting for future research on integration of care and cross-boundary working’. Workshop delegates then identified other experts in integrated care and cross-boundary working from their networks. In each eDelphi round, participants then provided item-by-item responses using a seven-point Likert scale, with consensus defined a priori as ≥80% agreement (strongly agree or agree). Priorities that reached consensus were conceptually grouped into topics.

Results
Twenty-five of 66 unique (37.9%) research priorities achieved consensus after two eDelphi rounds. In Round 1, 63/85 (74.1%) experts from 10 countries across 4 continents achieved consensus on 12/66 (18.2%) priorities. In Round 2, 51/63 (81.0%) experts achieved consensus on a further 13/54 (24.1%) priorities. From the 25 priorities, we derived six conceptual groupings that represent broad topics for future research on integrated care and cross-boundary working: (i) access to care, (ii) data sharing and technology, (iii) measurement of care quality, (iv) patient experience and satisfaction, (v) service design, integration and governance, and (vi) teamwork and leadership.

Conclusion
Integrating care services and improving cross-boundary working is important for improving the quality of care provided to patients, regardless of country. Therefore, the conceptual topics and individual priorities identified in this study can inform policymakers, practitioners, and researchers when designing or evaluating integrated care services across the world in pursuit of improved integrated care systems.
VMAP: Vaginal Microbiome Atlas during Pregnancy
Authors: Parraga-Leo Antonio , Oskotsky Tomiko T , Oskotsky Boris , Wibrand Camilla , Roldan Alennie , Tang Alice S , Ha Connie W Y , Wong Ronald J , Minot Samuel S , Andreoletti Gaia , Kosti Idit , Theis Kevin R , Ng Sherrianne , Lee Yun S , Diaz-Gimeno Patricia , Bennett Phillip R , MacIntyre David A , Lynch Susan V , Romero Roberto , Tarca Adi L , Stevenson David K , Aghaeepour Nima , Golob Jonathan L , Sirota Marina 
Published: September 2024

Abstract

Objectives
To enable interactive visualization of the vaginal microbiome across the pregnancy and facilitate discovery of novel insights and generation of new hypotheses.

Material and Methods
Vaginal Microbiome Atlas during Pregnancy (VMAP) was created with R shiny to generate visualizations of structured vaginal microbiome data from multiple studies.

Results
VMAP (http://vmapapp.org) visualizes 3880 vaginal microbiome samples of 1402 pregnant individuals from 11 studies, aggregated via open-source tool MaLiAmPi. Visualized features include diversity measures, VALENCIA community state types, and composition (phylotypes, taxonomy) that can be filtered by various categories.

Discussion
This work represents one of the largest and most geographically diverse aggregations of the vaginal microbiome in pregnancy to date and serves as a user-friendly resource to further analyze vaginal microbiome data and better understand pregnancies and associated outcomes.

Conclusion
VMAP can be obtained from https://github.com/msirota/vmap.git and is currently deployed as an online app for non-R users.
Quality–Quantity Tradeoffs in Consumption
Authors: Dias Rodrigo S , Sharma Eesha , Fitzsimons Gavan J 
Published: September 2024

Abstract
Tradeoffs between quality and quantity are widespread in consumer decision-making. While existing research has focused on situational and contextual factors driving choices of higher-quality or higher-quantity purchases, in the current work, we find that consumers possess generalized preferences for quality or quantity across purchase categories. Some consumers systematically prefer quality over quantity, and others systematically prefer quantity over quality. In 32 studies (N = 24,404) that use correlational, experimental, and longitudinal designs, and proprietary data from the Federal Reserve Bank, the current research introduces quality–quantity preferences as a novel facet of consumer decision-making. Studies 1–3 demonstrate quality–quantity preferences as an individual difference, develop the “quality-quantity tradeoffs” scale to measure it, and demonstrate that it is different from related existing constructs. Studies 4A–5 show that consumers who prefer quantity over quality spend more money, borrow more, and accrue more debt, indicating that quality–quantity preferences are consequential. Taken together, our findings underscore the importance of quality–quantity preferences as a driver of consumer behavior and pave the way for future research investigating the causes and consequences of consumers’ dispositions toward quality or quantity.
An investigation on coupling analysis and vibration rectification of vibration isolation system for strap-down inertia measurement unit
Authors: Hung Hsien-Hsiu , Huang Yu-Hsi , Ma Chien-Ching 
Published: September 2024

ABSTRACT
The development and deployment of high-precision positioning and orientation systems rely heavily on strap-down inertial measurement units (IMU), which are an integral part of aircraft navigation and launch systems. However, careful study and ongoing use of microelectromechanical systems inertial sensor assemblies (MEMS ISA) present the challenge of vibration disturbances that can significantly degrade the performance of IMU. To alleviate this problem, this paper proposes a vibration isolation system (VIS) based on a motion decoupling mechanism. The designed VIS dynamically decouples 6 degrees of freedom motion, effectively isolating the IMU from external vibrations while allowing free movement, thereby significantly improving control of vibration-induced motion changes. Our approach is validated through finite element simulations and random vibration tests, showing that the proposed VIS effectively reduces transmission measurement errors in IMU. The sensitivity of MEMS ISA to various vibration amplitudes and frequencies can lead to severe vibration correction errors. Therefore, reducing noise and offset is critical for systems that must operate reliably in harsh environments. This study not only explores vibration correction, but also provides a feasible solution through VIS design that can significantly reduce noise and deviation, helping to improve the durability and accuracy of the system. This research is clear that integrating well-designed VIS can significantly improve the resilience and accuracy of MEMS-based inertial systems, paving the way for more robust applications in the aerospace and defense industry.
Lost and found: a unique foregut gastrointestinal bullet embolism
Authors: Landwehr Hunter J , Hinton Jared B , Loudon Andrew M , Moorman Matthew L 
Published: September 2024

Abstract
Bullet embolism is a rare phenomenon where a bullet migrates from its original point of entry to a distant site within the body. This brief report describes a case of a bullet embolism entering the gastrointestinal (GI) tract through the posterior oropharynx. The patient initially presented with a gunshot wound to the left scapula, and the bullet was later identified in the GI tract. The patient was managed with a combination of endoscopic techniques and serial imaging, avoiding unnecessary surgical intervention. This case underscores the importance of comprehensive diagnostic strategies and tailored management in GI bullet embolism. It also emphasizes the utility of endoscopy in detecting GI tract injuries and highlights the successful use of non-operative management in specific scenarios.
Linking root cell wall width with plant functioning under drought conditions
Authors: Han Qinwen , Yang Qingpei , Guo Binglin , Kong Deliang 
Published: September 2024

This article comments on:
Sidhu JS, Lopez-Valdivia I, Strock CF, Schneider HM, Lynch JP. 2024. Cortical parenchyma wall width regulates root metabolic cost and maize performance under suboptimal water availability. Journal of Experimental Botany 75, https://doi.org/10.1093/jxb/erae191.
Imaging and Segmenting Grains and Subgrains Using Backscattered Electron Techniques
Authors: Bennett Thomas J , Taleff Eric M 
Published: September 2024

Abstract
We present two new methods of processing data from backscattered electron signals in a scanning electron microscope to image grains and subgrains. The first combines data from multiple backscattered electron images acquired at different specimen geometries to (1) better reveal grain boundaries in recrystallized microstructures and (2) distinguish between recrystallized and unrecrystallized regions in partially recrystallized microstructures. The second utilizes spherical harmonic transform indexing of electron backscatter diffraction patterns to produce high angular resolution orientation data that enable the characterization of subgrains. Subgrains are produced during high-temperature plastic deformation and have boundary misorientation angles ranging from a few degrees down to a few hundredths of a degree. We also present an algorithm to automatically segment grains from combined backscattered electron image data or grains and subgrains from high angular resolution electron backscatter diffraction data. Together, these new techniques enable rapid measurements of individual grains and subgrains from large populations.
Neo-Hasidism: The Questions are Theological
Authors: Green Arthur 
Published: September 2024

Abstract
The article opens with a brief definitional and historical summary of the phenomenon called Neo-Hasidism, referring to the adoption of Hasidic modes of thought, devotion, and praxis by Jews outside the traditional Hasidic communities. This is to be distinguished from Neo-Hasidism as a literary-artistic movement of the early twentieth century. The article then turns to what the author considers to be Hasidism’s most basic religious innovation, the popularization of a panentheistic notion of a God-infused universe and its implications for Hasidic Judaism. From here, he turns to some key theological issues as presented in early Hasidic sources, extensively quoted and referenced. These include concepts of God, revelation, mitzvot, and claims of religious exclusivism. In each case, he asks how this Hasidic view might be adapted for use in a contemporary neo-Hasidic context.
Prevalence of azole-resistant Aspergillus fumigatus and other aspergilli in the environment from Argentina
Authors: Molinero Rocío L , Hermida Alava Katherine S , Brito Devoto Tomás , Sautua Francisco , Carmona Marcelo , Cuestas María L , Pena Gabriela A 
Published: September 2024

Abstract
Azole resistance has emerged as a new therapeutic challenge in patients with aspergillosis. Various resistance mutations are attributed to the widespread use of triazole-based fungicides in agriculture. This study explored the prevalence of azole-resistant Aspergillus fumigatus (ARAF) and other aspergilli in the Argentine environment. A collection of A. fumigatus and other aspergilli strains isolated from soil of growing crops, compost, corn, different animal feedstuffs, and soybean and chickpea seeds were screened for azole resistance. No ARAF was detected in any of the environmental samples studied. However, five A. flavus, one A. ostianus, one A. niger and one A. tamarii recovered from soybean and chickpea seeds showed reduced susceptibility to medical azole antifungals (MAA). The susceptibility profiles of five A. flavus isolates, showing reduced susceptibility to demethylase inhibitors (DMIs), were compared with those of 10 isolates that exhibited susceptibility to MAA. Aspergillus flavus isolates that showed reduced MAA susceptibility exhibited different susceptibility profiles to DMIs. Prothioconazole and tebuconazole were the only DMIs significantly less active against isolates with reduced susceptibility to MAA. Although no ARAF isolates were found in the samples analysed, other aspergilli with reduced susceptibility profile to MAA being also important human pathogens causing allergic, chronic and invasive aspergillosis, are present in the environment in Argentina. Although a definitive link between triazole-based fungicide use and isolation of azole-resistant human pathogenic aspergilli from agricultural fields in Argentina remains elusive, this study unequivocally highlights the magnitude of the environmental spread of azole resistance among other Aspergillus species.
Evolution of HOD and galaxy properties in filaments and nodes of the cosmic web
Authors: Perez Noelia R , Pereyra Luis A , Coldwell Georgina , Alfaro Ignacio G , Rodriguez Facundo , Ruiz Andrés N 
Published: September 2024

ABSTRACT
We study the evolution of the halo occupation distribution (HOD) and galaxy properties of nodes and filamentary structures obtained by disperse from the Illustris TNG300-1 hydrodynamical simulation, in the redshift range $0 \le z \le 2$. We compute the HOD in filaments and nodes and fit the HOD parameters to study their evolution for both faint and bright galaxies. In nodes, the number of faint galaxies increases with decreasing redshift in the low-mass haloes, while no significant differences are seen in high-mass haloes. Limiting the HOD to bright galaxies shows that haloes increase in mass more than the number of bright galaxies they accrete. For filaments, no large differences in HOD are found for faint galaxies, although for brighter galaxies the behaviour is the same as in nodes. The HOD parametrization suggests that filaments have no effect on the mass required to host a galaxy (central or satellite), whereas nodes do. The results of the study indicate that with this parametrization, filaments do not seem to affect the stellar mass content of galaxies. In contrast, nodes appear to affect haloes with masses below approximately $10^{12.5} h^{-1} {\rm M}_{\odot }$ at local redshift. The analysis of the galaxy colour evolution shows a reddening towards lower redshift, although these processes seem to be more efficient in massive haloes, with a strong effect on bright galaxies. The general evolution suggests that the building of galaxy population within haloes is influenced by both the accretion of faint galaxies and the mass growth of the bright ones.
Exploring the early afterglow polarization of GRB 190829A
Authors: do E. S. Pedreira A C Caligula , Fraija N , Dichiara S , Veres P , Dainotti M G , Galvan-Gamez A , Becerra R L , Betancourt Kamenetskaia B 
Published: September 2024

ABSTRACT
GRB 190829A has been widely studied due to its nature and the high-energy emission presented. Due to the detection of a very high energy component by the High Energy Stereoscopic System and the event’s atypically middling luminosity, it has been categorized in a select, limited group of bursts bordering classic gamma-ray bursts (GRBs) and nearby sub-energetic events. Given the range of models utilized to adequately characterize the afterglow of this burst, it has proven challenging to identify the most probable explanation. Nevertheless, the detection of polarization data provided by the MASTER (Mobile Astronomical System of TElescope Robots) collaboration has added a new aspect to GRB 190829A that permits us to attempt to explore this degeneracy. In this paper, we present a polarization model coupled with a thin-shell synchrotron forward-shock model – a component in all models used to describe GRB 190829A’s afterglow – in order to fit the polarization’s temporal evolution with the existing upper limits ($\Pi &lt; 6{{\ \rm per\, cent}}$). We find that the polarization generated from an on-axis emission is favoured for strongly anisotropic magnetic field ratios, while an off-axis scenario cannot be fully ruled out when a more isotropic framework is taken into account.
Forming planetary systems that contain only minor planets
Authors: Veras Dimitri , Ida Shigeru 
Published: September 2024

ABSTRACT
Estimates of the frequency of planetary systems in the Milky Way are observationally limited by the low-mass planet regime. Nevertheless, substantial evidence for systems with undetectably low planetary masses now exists in the form of main-sequence stars that host debris discs, as well as metal-polluted white dwarfs. Further, low-mass sections of star formation regions impose upper bounds on protoplanetary disc masses, limiting the capacity for terrestrial or larger planets to form. Here, we use planetary population synthesis calculations to investigate the conditions that allow planetary systems to form only minor planets and smaller detritus. We simulate the accretional, collisional, and migratory growth of $10^{17}$ kg embryonic seeds and then quantify which configurations with entirely sub-Earth-mass bodies ($\lesssim\!\! 10^{24}$ kg) survive. We find that substantial regions of the initial parameter space allow for sub-terrestrial configurations to form, with the success rate most closely tied to the initial dust mass. Total dust mass budgets of up to $10^2 \ \mathrm{ M}_{\oplus }$ within 10 au can be insufficiently high to form terrestrial or giant planets, resulting in systems with only minor planets. Consequently, the prevalence of planetary systems throughout the Milky Way might be higher than what is typically assumed, and minor planet-only systems may help inform the currently uncertain correspondence between planet-hosting white dwarfs and metal-polluted white dwarfs.
CircaKB: a comprehensive knowledgebase of circadian genes across multiple species
Authors: Zhu Xingchen , Han Xiao , Li Zhijin , Zhou Xiaobo , Yoo Seung-Hee , Chen Zheng , Ji Zhiwei 
Published: September 2024

Abstract
Circadian rhythms, which are the natural cycles that dictate various physiological processes over a 24-h period, have been increasingly recognized as important in the management and treatment of various human diseases. However, the lack of sufficient data and reliable analysis methods have been a major obstacle to understanding the bidirectional interaction between circadian variation and human health. We have developed CircaKB, a comprehensive knowledgebase of circadian genes across multiple species. CircaKB is the first knowledgebase that provides systematic annotations of the oscillatory patterns of gene expression at a genome-wide level for 15 representative species. Currently, CircaKB contains 226 time-course transcriptome datasets, covering a wide variety of tissues, organs, and cell lines. In addition, CircaKB integrates 12 computational models to facilitate reliable data analysis and identify oscillatory patterns and their variations in gene expression. CircaKB also offers powerful functionalities to its users, including easy search, fast browsing, strong visualization, and custom upload. We believe that CircaKB will be a valuable tool and resource for the circadian research community, contributing to the identification of new targets for disease prevention and treatment. We have made CircaKB freely accessible at https://cdsic.njau.edu.cn/CircaKB.
PTMD 2.0: an updated database of disease-associated post-translational modifications
Authors: Huang Xinhe , Feng Zihao , Liu Dan , Gou Yujie , Chen Miaomiao , Tang Dachao , Han Cheng , Peng Jianzhen , Peng Di , Xue Yu 
Published: September 2024

Abstract
Various post-translational modifications (PTMs) participate in nearly all aspects of biological processes by regulating protein functions, and aberrant states of PTMs are frequently associated with human diseases. Here, we present a comprehensive database of PTMs associated with diseases (PTMD 2.0), including 342 624 PTM–disease associations (PDAs) in 15 105 proteins for 93 types of PTMs and 2083 diseases. Based on the distinct PTM states in diseases, we classified all PDAs into six categories: upregulation (U) or downregulation (D) of PTM levels, absence (A) or presence (P) of PTMs, and creation (C) or disruption (N) of PTM sites. We provided detailed annotations for each PDA and carefully annotated disease-associated proteins by integrating the knowledge from 101 additional resources that covered 13 aspects, including disease-associated information, variation and mutation, protein–protein interaction, protein functional annotation, DNA and RNA element, protein structure, chemical–target relationship, mRNA expression, protein expression/proteomics, subcellular localization, biological pathway annotation, functional domain annotation and physicochemical property. With a data volume of ∼8 GB, we anticipate that PTMD 2.0 will serve as a fundamental resource for further analysing the relationships between PTMs and diseases. The online service of PTMD 2.0 is freely available at https://ptmd.biocuckoo.cn/.
Phytoactives for Obesity Management: Integrating Nanomedicine for Its Effective Delivery
Authors: Mandal Ashok Kumar , Sahoo Ankit , Almalki Waleed H , Almujri Salem Salman , Alhamyani Abdulrahman , Aodah Alhussain , Alruwaili Nabil K , Abdul Kadir Sharifah Zamiah Binti Syed , Mandal Rambha Kumari , Almalki Rami A , Lal Jonathan A , Rahman Mahfoozur 
Published: September 2024

Abstract
Obesity is a global health concern that requires urgent investigation and management. While synthetic anti-obesity medications are available, they come with a high risk of side-effects and variability in their efficacy. Therefore, natural compounds are increasingly being used to treat obesity worldwide. The proposition that naturally occurring compounds, mainly polyphenols, can be effective and safer for obesity management through food and nutrient fortification is strongly supported by extensive experimental research. This review focuses on the pathogenesis of obesity while reviewing the efficacy of an array of phytoactives used for obesity treatment. It details mechanisms such as enzyme inhibition, energy expenditure, appetite suppression, adipocyte differentiation, lipid metabolism, and modulation of gut microbiota. Comprehensive in vitro, in vivo, and preclinical studies underscore the promise of phytoactives in combating obesity, which have been thoroughly reviewed. However, challenges, such as poor bioavailability and metabolism, limit their potential. Advances in nanomedicines may overcome these constraints, offering a new avenue for enhancing the efficacy of phytoactives. Nonetheless, rigorous and targeted clinical trials are essential before applying phytoactives as a primary treatment for obesity.