bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bidirectional relationship between self‐compassion and psychological richness: A two‐wave longitudinal study
Authors: Liu Yuening , Yang Xiaoni , Liu Yifan , Wei Cangpi , Zhao Jingjing , Kong Feng 
Published: October 2024

AbstractPrevious research has found that self‐compassion enhances well‐being outcomes such as happiness and meaning in life. However, little is known about the link between self‐compassion and psychological richness, a recently introduced concept of well‐being. Thus, an exploration of the relationship between self‐compassion and psychological richness is necessary to gain a comprehensive understanding of the association between self‐compassion and well‐being. To address this issue, this study investigated the temporal directionality of their relationship within a cohort of Chinese college students, utilizing a two‐wave longitudinal approach. Using a cross‐lagged model, the results revealed that the self‐compassion could predict psychological richness 3 months later, and conversely, psychological richness could also predict subsequent self‐compassion. This research provides new insights into the bidirectional relationship between self‐compassion and psychological richness, broadening our understanding of the association between self‐compassion and well‐being. Future interventions should focus on the important effect of self‐compassion interventions in the development of psychological richness. In addition, future research could consider interventions on increasing psychological richness to improve the level of self‐compassion among college students.
Evidence of glass bead‐making in the early Islamic Iberian Peninsula
Authors: Boschetti Cristina , de Juan Ares Jorge , Gilotte Sophie , Guerrot Catherine , Schibille Nadine 
Published: October 2024

AbstractGlass beads from two Islamic archaeological sites in the Tagus valley in central Spain were selected and analysed by laser ablation inductively coupled plasma mass spectrometry (LA‐ICP‐MS), and a subset of samples (n = 6) was analysed for Pb isotopes by multicollector thermal ionization mass spectrometry (MC‐TIMS). The analytical and isotopic data of the beads from Ciudad de Vascos (Toledo) and Albalat (Cáceres) demonstrate beyond reasonable doubt that glass beads were produced in the Iberian Peninsula during the Islamic period using local Pb‐silica and soda‐rich plant‐ash glass. The bead workshops in al‐Andalus were evidently part of an efficient system of glass collection and recycling, and used only relatively simple bead‐making techniques such as winding and folding. At present it is unclear to what extent the Islamic bead‐makers in the Iberian Peninsula were involved in the international trade in glass beads or whether their products were mainly destined for a regional market. Despite local production, some samples show compositional and typological features that suggest the import of finished glass beads, perhaps from Central Asia.
A majority group perspective on the association between perceived national identification of minority groups and minority helping
Authors: Mashuri Ali , Minza Wenty Marina , Rahmi Tuti 
Published: October 2024

AbstractPrevious research has shown that majority group members are more willing to help minority group members of the same nation, particularly when the majority group members strongly identify with the national group. However, existing research has overlooked the extent to which the majority group's perception of how strongly minority groups identify with the national group (i.e., the perceived national identification of minority groups) explains minority helping (i.e., the majority group's intentions to help minority groups). To fill this void, we conducted a correlational survey among 980 Javanese, the ethnic majority in Indonesia. The results revealed that the perceived national identification of non‐Javanese minorities positively corresponded with the majority group's national identification. More perceived national identification of the minority groups and the majority group's national identification significantly correlated with more positive attitudes, liking, and helping intentions toward the minority groups. Finally, the perceptions that the non‐Javanese rejected the majority group's aspiration to exert control over them (i.e., the perceived denial of the need for power) negatively predicted the perceived national identification of the minority groups and minority helping. The perceived national identity of minority groups can influence minority helping; however, the perceived denial of the need for power may hinder it.
Efficacy of decision aid delivery modes in prostate cancer screening: umbrella review and network meta‐analysis
Authors: Ang Zen Yang , Kong Yuke‐Lin , Md Nesran Zarith Nameyrra , Lee Shaun Wen Huey 
Published: October 2024

ObjectiveTo review and compare the efficacy of different delivery modes of decision aids (DAs), including computer‐based, print‐based, multimedia‐based, video‐based, and website‐based on decision‐making outcomes for prostate cancer screening compared to usual care (UC) and among the delivery modes.MethodsPubMed, the Excerpta Medica dataBASE (EMBASE), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Google Advanced Search, and Turning Research Into Practice (TRIP) Database were systematically searched from inception to August 2023. The primary outcomes were knowledge level, knowledge scores, participation in shared decision‐making (SDM), decisional conflict, and preference for SDM participation. Secondary outcomes were the proportion of subjects who underwent screening (actual screening utilisation) and the proportion of subjects who intended to be screened (intention to undergo screening). Network and pairwise meta‐analyses were performed using random‐effects models.ResultsSeven systematic reviews were included. Network meta‐analysis found that multimedia (relative risk [RR] 1.51, 95% confidence interval [CI] 1.02–2.24), print (RR 1.82, 95% CI 1.23–2.69), and website‐based (RR 1.99, 95% CI 1.32–3.01) DAs significantly increased participation in SDM compared to the computer‐based DA. There was a significant reduction in the actual screening utilisation in the computer DA arm compared to the other delivery modes. No significant differences between all delivery modes were noted on knowledge levels, knowledge scores, decisional conflict, preference for SDM participation, and intention to undergo screening. The highest mean surface under the cumulative ranking curve for all primary outcomes showed that website‐based was the most effective delivery mode, followed by print‐based DA. The pairwise meta‐analysis showed a significant increase in participants’ knowledge level, knowledge scores, a reduced intention to undergo screening and actual screening utilisation compared to UC.ConclusionsThe findings suggest that different types of DAs have varying levels of effectiveness in increasing knowledge level, knowledge scores, participation in SDM, and influencing screening behaviours. While website‐based DA appeared the most effective, employing the print‐based DA could be a practical solution in settings with limited resources.
miR‐210 as a therapeutic target in diabetes‐associated endothelial dysfunction
Authors: Collado Aida , Jiao Tong , Kontidou Eftychia , Carvalho Lucas Rannier Ribeiro Antonino , Chernogubova Ekaterina , Yang Jiangning , Zaccagnini Germana , Zhao Allan , Tengbom John , Zheng Xiaowei , Rethi Bence , Alvarsson Michael , Catrina Sergiu‐Bogdan , Mahdi Ali , Carlström Mattias , Martelli Fabio , Pernow John , Zhou Zhichao 
Published: October 2024

AbstractBackground and PurposeMicroRNA (miR)‐210 function in endothelial cells and its role in diabetes‐associated endothelial dysfunction are not fully understood. We aimed to characterize the miR‐210 function in endothelial cells and study its therapeutic potential in diabetes.Experimental ApproachTwo different diabetic mouse models (db/db and Western diet‐induced), miR‐210 knockout and transgenic mice, isolated vessels and human endothelial cells were used.Key ResultsmiR‐210 levels were lower in aortas isolated from db/db than in control mice. Endothelium‐dependent relaxation (EDR) was impaired in aortas from miR‐210 knockout mice, and this was restored by inhibiting miR‐210 downstream protein tyrosine phosphatase 1B (PTP1B), mitochondrial glycerol‐3‐phosphate dehydrogenase 2 (GPD2), and mitochondrial oxidative stress. Inhibition of these pathways also improved EDR in both diabetic mouse models. High glucose reduced miR‐210 levels in endothelial cells and impaired EDR in mouse aortas, effects that were reversed by overexpressing miR‐210. However, plasma miR‐210 levels were not affected in individuals with type 2 diabetes (T2D) following improved glycaemic status. Of note, genetic overexpression using miR‐210 transgenic mice and pharmacological overexpression using miR‐210 mimic in vivo ameliorated endothelial dysfunction in both diabetic mouse models by decreasing PTP1B, GPD2 and oxidative stress. Genetic overexpression of miR‐210 altered the aortic transcriptome, decreasing genes in pathways involved in oxidative stress. miR‐210 mimic restored decreased nitric oxide production by high glucose in endothelial cells.Conclusion and ImplicationsThis study unravels the mechanisms by which down‐regulated miR‐210 by high glucose induces endothelial dysfunction in T2D and demonstrates that miR‐210 serves as a novel therapeutic target.LINKED ARTICLESThis article is part of a themed issue Non‐coding RNA Therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v182.2/issuetoc
Pharmacology of PIEZO1 channels
Authors: Kinsella Jacob A. , Debant Marjolaine , Parsonage Gregory , Morley Lara C. , Bajarwan Muath , Revill Charlotte , Foster Richard , Beech David J. 
Published: October 2024

AbstractPIEZO1 is a eukaryotic membrane protein that assembles as trimers to form calcium‐permeable, non‐selective cation channels with exquisite capabilities for mechanical force sensing and transduction of force into effect in diverse cell types that include blood cells, endothelial cells, epithelial cells, fibroblasts and stem cells and diverse systems that include bone, lymphatics and muscle. The channel has wide‐ranging roles and is considered as a target for novel therapeutics in ailments spanning cancers and cardiovascular, dental, gastrointestinal, hepatobiliary, infectious, musculoskeletal, nervous system, ocular, pregnancy, renal, respiratory and urological disorders. The identification of PIEZO1 modulators is in its infancy but useful experimental tools emerged for activating, and to a lesser extent inhibiting, the channels. Elementary structure–activity relationships are known for the Yoda series of small molecule agonists, which show the potential for diverse physicochemical and pharmacological properties. Intriguing effects of Yoda1 include the stimulated removal of excess cerebrospinal fluid. Despite PIEZO1's broad expression, opportunities are suggested for selective positive or negative modulation without intolerable adverse effects. Here we provide a focused, non‐systematic, narrative review of progress with this pharmacology and discuss potential future directions for research in the area.
Being family via WeChat: Children's interpretation of long‐distance family relationships
Authors: Han Xiaoying 
Published: October 2024

AbstractThis study explores how left‐behind children in rural China maintain long‐distance family relationships through WeChat, highlighting the significant role of social media during family separation. It underscores the importance of considering children's voices in understanding family relationships in the digital age. Drawing on online workshops and interviews with 41 participants, the research examines how Chinese left‐behind children use WeChat to facilitate parental engagement and manage their emotions. It also investigates the challenges children face in online communication and their perspectives on grandparental involvement. This article argues that children's agency is situated within structural conditions shaped by a confluence of factors, including technological affordances, unique familial contexts, and socio‐economic inequalities. This situatedness fosters creativity, compromises, and adaptations in ‘being family’ at a distance.
Identifying modifiable factors associated with neuroimaging markers of brain health
Authors: Huang Liang‐Yu , Fu Yan , Zhang Yi , Hu He‐Ying , Ma Ling‐Zhi , Ge Yi‐Jun , Zhao Yong‐Li , Zhang Ya‐Ru , Chen Shi‐Dong , Feng Jian‐Feng , Cheng Wei , Tan Lan , Yu Jin‐Tai 
Published: October 2024

AbstractAimsBrain structural alterations begin long before the presentation of brain disorders; therefore, we aimed to systematically investigate a wide range of influencing factors on neuroimaging markers of brain health.MethodsUtilizing data from 30,651 participants from the UK Biobank, we explored associations between 218 modifiable factors and neuroimaging markers of brain health. We conducted an exposome‐wide association study using the least absolute shrinkage and selection operator (LASSO) technique. Restricted cubic splines (RCS) were further employed to estimate potential nonlinear correlations. Weighted standardized scores for neuroimaging markers were computed based on the estimates for individual factors. Finally, stratum‐specific analyses were performed to examine differences in factors affecting brain health at different ages.ResultsThe identified factors related to neuroimaging markers of brain health fell into six domains, including systematic diseases, lifestyle factors, personality traits, social support, anthropometric indicators, and biochemical markers. The explained variance percentage of neuroimaging markers by weighted standardized scores ranged from 0.5% to 7%. Notably, associations between systematic diseases and neuroimaging markers were stronger in older individuals than in younger ones.ConclusionThis study identified a series of factors related to neuroimaging markers of brain health. Targeting the identified factors might help in formulating effective strategies for maintaining brain health.
Identifying climate‐smart tropical Key Biodiversity Areas for protection in response to widespread temperature novelty
Authors: Trew Brittany T. , Lees Alexander C. , Edwards David P. , Early Regan , Maclean Ilya M. D. 
Published: October 2024

AbstractKey Biodiversity Areas (KBAs) are a cornerstone of 21st‐century area‐based conservation targets. In tropical KBAs, biodiversity is potentially at high risk from climate change, because most species reside within or beneath the canopy, where small increases in temperature can lead to novel climate regimes. We quantify novelty in temperature regimes by modeling hourly temperatures below the forest canopy across tropical KBAs between 1990 and 2019. We find that up to 60% of KBAs with tropical forests have recently transitioned to novel temperature regimes. Nevertheless, 40% of KBAs are providing refuge from novelty, 65% of which are not protected. By conducting the first pan‐tropical analyses of changes in below‐canopy temperature conditions in KBAs, we identify KBAs that are acting as climate refugia and should be considered for expansion of the conservation network in response to the post‐2020 Global Biodiversity Framework target to conserve 30% of land area by 2030.
Clinical Management in NSCLC Patients With EGFR Mutation After Osimertinib Progression With Unknown Resistance Mechanisms
Authors: Liao Xin , He Tingting , Wan Xiong , Liu Pian , Li Jing , He Yong , Wang Yubo 
Published: October 2024

ABSTRACTBackgroundOsimertinib is approved as a standard treatment for non‐small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation by FDA. However, the mechanisms of resistance for nearly half of patients after osimertinib progression are still unknown, and the optimal therapies for these patients are still controversial. In this retrospective study, we compared efficacy and safety between immunotherapy + chemotherapy, chemotherapy alone, and osimertinib + bevacizumab in NSCLC patients after osimertinib progression with unknown resistance mechanisms.MethodsAdvanced NSCLC patients with unknown resistance mechanisms after osimertinib progression were retrospectively reviewed and divided into immunotherapy + chemotherapy, chemotherapy alone, and osimertinib + bevacizumab treatment groups according to the treatment they received after osimertinib progression. Clinicopathological features, objective response rate (ORR), progression‐free survival (PFS), and overall survival (OS) were compared between groups.ResultsA total of 121 patients were enrolled in this study, 22 in the immunotherapy + chemotherapy group, 72 in the chemotherapy group, and 27 in the osimertinib + bevacizumab group. The ORR was much higher in the immunotherapy + chemotherapy group compared with chemotherapy or osimertinib + bevacizumab group (55.56% vs. 14.81% vs. 0% in patients after progression on 1st line osimertinib treatment; 30.77% vs. 6.67% vs. 13.33% in patients after progression on 2nd/3rd line osimertinib treatment). Median PFS was also significantly longer in the immunotherapy + chemotherapy group compared with other groups (8.2 months vs. 4.0 months vs. 6.0 months in all patients, p = 0.0066). The median OS did not reach remarkable difference among groups, although osimertinib + bevacizumab group had a numerically longer median OS (37.0 months vs. 37.0 months vs. 47.6 months in all patients, p = 0.6357). Compared with immunotherapy + chemotherapy and chemotherapy, treatment‐related adverse events (AEs) of osimertinib + bevacizumab were milder, especially in AEs related to gastrointestinal and bone marrow suppression.ConclusionOur study provides clinical evidence that NSCLC patients after osimertinib progression with unknown resistance mechanisms may benefit from immunotherapy + chemotherapy, with higher ORR and longer PFS compared with osimertinib + bevacizumab or chemotherapy groups. Osimertinib + bevacizumab treatment was also an optional option for patients because OS was numerically longer and safer in this group.
Multidecadal underwater surveys reveal declines in marine turtles
Authors: Saltzman Julia , Hearn Alex R. , Fuentes Mariana M. P. B. , Steiner Todd , Arauz Randall , Macdonald Catherine , Heidemeyer Maike , White Easton R. 
Published: October 2024

AbstractMarine turtles are a group of imperiled marine megafauna particularly vulnerable to anthropogenic stressors. Most long‐term studies of marine turtles are based on nesting surveys which focus on numbers of eggs, hatchlings, and nesting females. However, we know less about long‐term abundance trends of immature and adult turtles in the marine environment. To address this data gap, we examined records from 35,000 underwater visual census (UVC) dives (1993–2019) and short‐term in‐water turtle survey data (2009–2014) at Cocos Island, Costa Rica. During UVCs, trained divemasters from UnderSea Hunter recorded observations of two species of marine turtles—green Chelonia mydas and hawksbill Eretmochelys imbricata. Our short‐term in‐water surveys revealed that most turtles at Cocos are greens, but both immature and mature greens occur at Cocos. We analyzed long‐term UVC data using a hierarchical modeling approach and we modeled a 26% decrease in the relative abundance of turtles observed on dives each year. Our model also revealed potential interactions between tiger sharks and turtles, finding that for each additional tiger shark present during a dive, the predicted relative abundance of turtles decreased by 43%. Lastly, our model suggested the influence of environmental variation on marine turtle relative abundance; a 1°C increase in sea surface temperature (SST) decreased the predicted relative abundance of turtles by 7%. Our results suggest that marine turtles are sensitive to long‐term environmental and oceanographic changes, and potentially avoid certain areas to reduce exposure to tiger sharks. Given our study area is already protected, there needs to be more focus on protecting adult turtles during their movements across the Eastern Tropical Pacific. Our work also highlights the importance of long‐term underwater surveys to monitor adult turtles.
Seeing the Big‐ to Fine‐Grained Picture: Exploring the Baseline Status of Mammal Occupancy Across Myanmar Using Scale‐Optimised Modelling
Authors: Kyaw Pyae Phyoe , Cushman Samuel A. , Kaszta Żaneta , Burnham Dawn , Zaw Than , Naing Hla , Htun Saw , Moe Kyaw , Tun Aung Ye , Myo Okka , Aung Zarni , Myo Khin Myo , Aung Htet Arkar , Po Saw Htoo Tha , Po Saw Ehkhu , Tun Saw William L. , Nay Saw Hay , Macdonald David W. 
Published: October 2024

ABSTRACTAimMyanmar, an Indo‐Burmese biodiversity hotspot, lacks baseline data on species occurrence and distribution. This hinders biodiversity monitoring and optimisation of conservation and development plans. We aim to document baseline mammal occupancy, interactions with environmental factors and scale‐dependent responses.LocationHkakaborazi National Park, Htamanthi Wildlife Sanctuary, Alaungdaw Kathapa National Park, Rakhine Yoma Elephant Range, Say Taung and Myinmoletkhat Key Biodiversity Areas distributed across Myanmar.MethodsCamera trap data throughout Myanmar were used to analyse species occupancy. We conducted a multiscale hierarchical spatial modelling process, using local and pooled data across Myanmar. We also optimised spatial scale across five scales and six predictors, using univariate occupancy models. We then selected scale‐optimised variables for multivariate modelling, repeating this process for each species across local, regional and national datasets.ResultsThe study identified 47 terrestrial species and observed strong scale‐dependent nonstationarity in occupancy estimates. Relationships with environmental variables differed among species and were highly scale dependent. Importantly, occupancy estimates produced by pooling data across sites were greatly different from any of the estimates for the individual sites, suggesting that high heterogeneity in occurrence and abundance across sites among species requires local or nested occupancy estimates to account for spatial heterogeneity and variation.Main ConclusionsFuture conservation efforts should focus on Northern Myanmar if range‐restricted and rare species are to be protected, while focus should still be given to common species which serve as potential indicators of overall community structure. The nonstationarity of occupancy results from different datasets underscores the potential for misleading interpretations from aggregated data in nonstationary ecological systems. Metareplicated analyses of local, geographically and ecologically proximal regional datasets provide an important view of spatial variation in occupancy patterns guiding conservation design and improving understanding of the drivers of biodiversity patterns and change across large regions, such as Southeast Asia.