bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor Characteristics Associated With Preoperatively Detectable Tumor-Informed Circulating Tumor DNA in Patients With Renal Masses Suspicious for Renal Cell Carcinoma
Authors: Ben-David Reuben , Alerasool Parissa , Kalola Hitasha , Tillu Neeraja , Almoflihi Mohammed , Tsao Che-Kai , Galsky Matthew D. , Sfakianos John P. , Wiklund Peter , Waingankar Nikhil , Mehrazin Reza 
Published: September 2024

PURPOSE
Understanding the specific tumor characteristics associated with detectable circulating tumor DNA (ctDNA) in patients with renal cell carcinoma (RCC) is critical for informing future studies aiming to establish the clinical utility of such testing. We characterized the pathologic and clinical features associated with preoperatively detectable ctDNA in patients with renal masses suspicious for RCC.

METHODS
Consecutive patients who underwent partial or radical nephrectomy for nonmetastatic suspected RCC (cT1b-T3) during 2022-2023 had prospectively collected tumor-informed ctDNA analyses conducted preoperatively and postoperatively. Descriptive statistics and univariate analyses were used to describe the study findings.

RESULTS

Sixty-nine patients with a median age of 62 years (IQR, 51-70) and a median follow-up time of 7 months (IQR, 3-11) had 205 ctDNA samples collected for analysis. Thirty-nine (61%) had preoperative detectable ctDNA of 64 patients. Postoperative ctDNA status was available for 47 patients, and three (6%) had detectable ctDNA. Two had inferior vena cava (IVC) involvement, and one developed metastatic disease. Subgroup analysis of solely malignant RCC (n = 65) revealed that patients with preoperative detectable ctDNA had a higher pathologic stage (
P
= .001), larger tumors (7
v
4.5 cm;
P
= .001), higher tumor complexity (
P
= .022), and increased rates of tumor grades 3-4 (
P
= .038). All patients with gross renal vein or IVC involvement (n = 9) and those with lymphovascular invasion (n = 6) on pathology had detectable preoperative ctDNA. On univariate analysis, high tumor complexity, larger tumors, and tumor grades 3-4 were found to be predictors of preoperatively detectable ctDNA status.

CONCLUSION
Preoperative ctDNA was detectable in 61% of patients with nonmetastatic RCC, and it correlated with clinically relevant features. Clinical trials should consider incorporating both preoperative and postoperative ctDNA analyses to augment prediction of disease recurrence and to refine treatment decision making.
Vitamin D-dependent Rickets Type 1A Mimicking Pseudohypoparathyroidism in Presence of Active Tuberculosis
Authors: Das Sambit , Agarwal Vishal , Prusty Binod , Das Bijay Ketan , Choudhury Arun , Meher Dayanidhi 
Published: September 2024

Abstract
Vitamin D-dependent rickets type 1A is caused by pathogenic variants of CYP27B1 gene, which is inherited in autosomal recessive pattern. These variants lead to defective 1α-hydroxylase enzymatic activity, leading to impaired renal formation of 1,25(OH)2 vitamin D. We report a case of a 16-year-old Asian male patient, with short stature and progressive bone deformity, whose biochemical parameters revealed low levels of 1,25(OH)2 vitamin D, low serum calcium levels, along with high phosphorus and raised levels of intact parathyroid hormone. These biochemical parameters suggested the diagnosis of pseudohypoparathyroidism. The patient also had concurrent extrapulmonary tuberculosis during the time of presentation to our endocrine unit. However, on molecular testing, it was revealed that the patient was harboring pathogenic variants of the CYP27B1 gene, in a compound heterozygous manner, with a novel missense mutation in exon 6 of the CYP27B1 gene, c.1136G &gt; C (p.Arg379Thr), suggesting the diagnosis of vitamin D-dependent rickets type 1A. The cause of high phosphorus at the time of presentation, which led to a diagnostic dilemma of pseudohypoparathyroidism, was later explained by presence of active extra pulmonary tuberculosis. This report describes a case of vitamin D-dependent rickets type 1A, mimicking pseudohypoparathyroidism owing to presence of concurrent illness like extrapulmonary tuberculosis.
The high price of equity in pulse oximetry: A cost evaluation and need for interim solutions
Authors: Dempsey Katelyn , Matos Joao , McMahon Timothy , Lindsay Mary , Tcheng James E. , Wong An-Kwok Ian 
Published: September 2024

Disparities in pulse oximetry accuracy, disproportionately affecting patients of color, have been associated with serious clinical outcomes. Although many have called for pulse oximetry hardware replacement, the cost associated with this replacement is not known. The objective of this study was to estimate the cost of replacing all current pulse oximetry hardware throughout a hospital system via a single-center survey in 2023 at an academic medical center (Duke University) with three hospitals. The main outcome was the cost of total hardware replacement as identified by current day prices for hardware. New and used prices for 3,542/4,136 (85.6%) across three hospitals for pulse oximetry devices were found. The average cost to replace current pulse oximetry hardware is $6,834.61 per bed. Replacement and integration costs are estimated at $14.2–17.4 million for the entire medical system. Extrapolating these costs to 5,564 hospitals in the United States results in an estimated cost of $8.72 billion. “Simply replacing” current pulse oximetry hardware to address disparities may not be simple, cheap, or timely. Solutions for addressing pulse oximetry accuracy disparities leveraging current technology may be necessary, and might also be better.
Trial Registration: Pro00113724, exempt.
Effectiveness of art-based health education on anemia and health literacy among pregnant women in Western Nepal: A randomized controlled trial
Authors: Sakai Hiroko , Kawata Rina , Adhikari Rajesh , Thapa Yoko Oda , Bhandari Tulsi Ram 
Published: September 2024

Objective
As Nepalese pregnant women vary widely in literacy levels and cultural backgrounds and are reluctant to make decisions about their health, general interventions are insufficient to improve maternal anemia. This study aimed to assess the effectiveness of “face-to-face health education using educational material created using pictures, photos, and nomograms” in reducing anemia and improving health literacy.

Methods
A total of 156 Nepalese pregnant women with hemoglobin (Hb) levels below 11.0 g/dl were divided into three groups: the education group received three sessions of face-to-face health education using art-based material unaffected by literacy skills; the distribution group received material used in the education group; and the control group underwent general perinatal checkups. Hb levels and health literacy scores were assessed at baseline early pregnancy (8–12 weeks) and late pregnancy (36–40 weeks). A Nepalese version of the 14-item Health Literacy Scale (HLS-14) was developed to assess health literacy.

Results
The post-intervention three-group comparison showed a statistically significant difference (P < 0.042) in mean Hb levels after the intervention. Dunnett’s test showed a statistically significant difference (P < 0.044) between the education and control groups but no significant difference between the distribution and control groups (P = 0.972). No significant differences in health literacy (total scores and subscales) were observed among the three groups before the intervention in the Kruskal-Wallis test and after the intervention (although there was a trend towards improvement). Total health literacy scores before and after the intervention were statistically significantly different for the total group and all three groups (P<0.001). Only the education group showed statistically significant differences in functional (P<0.012), communication (P<0.004), and critical (P<0.014) literacy subscale scores.

Conclusion
Continuous face-to-face health education using literacy material significantly reduced anemia and improved health literacy among Nepalese pregnant women.

Trial registration
UMIN Clinical Trials Registry (UMIN-CTR), URL: https://www.umin.ac.jp/ctr/ (Registration number: UMIN000049603).
Cost-effectiveness analysis of COVID-19 booster doses and oral antivirals: Case studies in the Indo-Pacific
Authors: Bilgin Gizem Mayis , Munira Syarifah Liza , Lokuge Kamalini , Glass Kathryn 
Published: September 2024

Background
Decision-makers in middle-income countries need evidence on the cost-effectiveness of COVID-19 booster doses and oral antivirals to appropriately prioritise these healthcare interventions.

Methods
We used a dynamic transmission model to assess the cost-effectiveness of COVID-19 booster doses and oral antivirals in Fiji, Indonesia, Papua New Guinea, and Timor-Leste. We conducted cost-effectiveness analysis from both healthcare and societal perspectives using data collated from publicly available sources. We developed an interactive R Shiny which allows the user to vary key model assumptions, such as the choice of discounting rate, and view how these assumptions affect model results.

Findings
Booster doses were cost saving and therefore cost-effective in all four middle-income settings from both healthcare and societal perspectives using 3% discounting. Providing oral antivirals was cost-effective from a healthcare perspective if procured at a low generic price (US$25) or middle-income reference price (US$250); however, their cost-effectiveness was strongly influenced by rates of wastage or misuse, and the ongoing costs of care for patients hospitalised with COVID-19. The cost or wastage of rapid antigen tests did not appear strongly influential over the cost-effectiveness of oral antivirals in any of the four study settings.

Conclusions
Our results support that COVID-19 booster programs are cost-effective in middle-income settings. Oral antivirals demonstrate the potential to be cost-effective if procured at or below a middle-income reference price of US$250 per schedule. Further research should quantify the rates of wastage or misuse of oral COVID-19 antivirals in middle-income settings.
Chest X-ray findings of COVID-19 pneumonia in children: Experiences in a multicenter study in Thailand
Authors: Kulbun Aunya , Tovichien Prakarn , Chaiyakulsil Chanapai , Satdhabudha Araya , Kamalaporn Harutai , Sunkonkit Kanokkarn , Uppala Rattapon , Niyomkarn Watit , Norasettekul Vasinee , Ruangnapa Kanokpan , Smathakanee Chutima , Choursamran Bararee , Jaroenying Rasintra , Sriboonyong Tidarat , Sitthikarnkha Phanthila , Roekworachai Koonkoaw , Ratanavongkosol Thanyarat , Thongnual Chutima , Deerojanawong Jitladda 
Published: September 2024

Introduction
Although chest X-ray is commonly used to diagnose COVID-19 pneumonia, few studies have explored findings in pediatric patients. This study aimed to reveal chest X-ray characteristics in children with COVID-19 pneumonia and compare between non-severe and severe cases.

Methods
This multicenter, nationwide retrospective study included all children aged 0 to 15 years who were admitted to 13 medical facilities throughout Thailand with COVID-19 pneumonia between January 2020 and October 2021. We analyzed the demographics, clinical features, and chest X-ray results of these children, and compared differences between the non-severe and severe groups.

Results
During the study period, 1018 children (52% male, median age 5 years) were admitted with COVID-19 pneumonia. Most chest radiographic findings showed bilateral (51%) patchy/ground glass opacities (61%) in the central area (64%). Only 12% of the children exhibited typical classification for COVID-19 pneumonia, whereas 74% of chest radiographs were categorized as indeterminate. Comorbidities including chronic lung diseases [adjusted OR (95%CI): 14.56 (3.80–55.75), P-value <0.001], cardiovascular diseases [adjusted OR (95%CI): 7.54 (1.44–39.48), P-value 0.017], genetic diseases [adjusted OR (95%CI): 28.39 (4.55–177.23), P-value <0.001], clinical dyspnea [adjusted OR (95%CI): 12.13 (5.94–24.77), P-value <0.001], tachypnea [adjusted OR (95%CI): 3.92 (1.79–8.55), P-value 0.001], and bilateral chest X-ray infiltrations [adjusted OR (95%CI): 1.99 (1.05–3.78), P-value 0.036] were factors associated with severe COVID-19 pneumonia.

Conclusion
Most children with COVID-19 pneumonia had indeterminate chest X-rays according to the previous classification. We suggest using chest X-rays in conjunction with clinical presentation to screen high-risk patients for early detection of COVID-19 pneumonia.
A felsőoktatás szerepe az aktív idősödés támogatásában: Intergenerációs tanulás során szerzett tapasztalat vizsgálata az időskorúak és felsőoktatási hallgatók esetében
Authors: Schiller Emese , Dorner Helga , Antesberger Klára 
Published: September 2024

Az intergenerációs együttműködést támogató kezdeményezések elsődleges célja a különböző korosztályok közötti elfogadás elősegítése (Kaplan et al., 2017), valamint az aktív időskor támogatása (Aláez et al., 2022). A felsőoktatási intézmények kiemelt szerepet játszanak ezen kezdeményezések elősegítésében (Corrigan et al., 2013). Jelen tanulmány célja az intergenerációs tanulási tapasztalatok vizsgálata felsőoktatási színtéren. A kutatás 2022 őszén zajlott az ELTE Pedagógiai és Pszichológiai Karán egy nemzetközi konzorciális partnerség keretében, melynek alapvető célja az aktív időskor támogatási lehetőségeinek vizsgálata volt. A kutatás az intergenerációs tanulási projektben résztvevő ELTE egyetemi hallgatók (n=6) és idősebb önkéntes résztvevők (n=8) reflexióit tártja fel a tanulási tapasztalataik kapcsán, tekintettel az intergenerációs tanulás során fejlődni vélt készségekre, valamint a folyamatot segítő és hátráltató tényezőkre. A vizsgálat során mindkét korosztály esetében fókuszcsoportos interjúkat alkalmaztunk, és az adatok szintéziséhez diskurzuselemzést végeztünk (Krzyzanowksi, 2015), különös figyelmet fordítva az interakciók jellegének vizsgálatára.Az elemzésben bemutatott induktív elemek és az azokkal kapcsolatos interakciók vizsgálata alapján láthatóak a két korcsoport közötti különbségek, valamint a csoportokon belül előforduló egyetértések, illetve különbözőségek. Mindkét korcsoport esetében felmerült a kooperatívitás, valamint kompromisszum-készség területén tapasztalt fejlődés, melynek más kontextusban való alkalmazásának lehetőségét különösen a fiatalabb résztvevők hangsúlyozták. Ezenfelül mindkét korosztály képviselője reflektált a projekt során tapasztalt kihívásokra, melyek főként a kommunikációs nehézségekben mutatkoztak meg. Azonban egyes résztvevők esetében a projekthez való hozzáállás, mások esetében a korkülönbség, valamint a különböző munkamorál jelentek meg meghatározó különbségként. Az oktatói facilitálás, mint támogató tényező kapott nagyobb hangsúlyt a fiatalabb résztvevők részéről; fontosságát egyöntetűen hangsúlyozták. Az intergenerációs tanulás hosszútávú fenntarthatósága kapcsán, annak egyetemi kurzusba való integrálásának potenciálja is felmerült a fókuszcsoportos beszélgetések során.
Al-Tadlīl ‘alā Imāmah Abī Bakr min Khilāli Tafsīr al-Māturīdī
Authors: Ünsal Hadiye 
Published: September 2024

Abū Manṣūr Muḥammad b. Maḥmūd al-Samarḳandī (d. 333/944), the founder of the Māturīdiyya sect, is one of the significant scholars of the Hanafi sect. Imam Māturīdī is a scholar in the history of Islamic science who became famous for a theologian (mutaqallim), interpreter (mufassir) and jurist (faqīh), and is known for his Kitāb al-Tawḥīd. Besides that, Māturīdī and his commentary entitled Taʼwīlāt al-Qurʼān - one of the earliest tafsir bi al-ra’y (bi-al dirayah) examples of the exegetical literature- have broadly been studied in Turkish theology academia especially in recent years. This study aims to discuss the verses related to Abū Bakr’s (d. 13/634) caliphate in Imam al-Māturīdī’s Taʼwīlāt al-Qurʼān in terms of the distinction between tafsir and ta’wil. As it is known, the distinction between tafsir and ta’wil is based on Māturīdī’s writings. According to this distinction, tafsir is the process of interpretation particularly by the companions whereas ta’wil is done by the fuqaha. Therefore it is appropriate to say that tafsir means “contextual meaning” while ta’wil stands for “commentation.” As a matter of fact, Māturīdī also explains the word tafsir as the first and original meaning of the Qur’an in the context of its revelation. However, he explains in his Taʼwīlāt al-Qurʼān many verses by associating them with some issues that emerged after the revelation of the Qur’an, thus making “ta’wil.” Moreover, he gave the title Taʼwīlāt to his work in accordance with this understanding. In this study, it will be discussed whether Māturīdī’s well-known definition of tafsir contradicts or not with his commentation on the verses that he claims pointing to Abū Bakr’s caliphate and/or his superiority. The verses considered evidence for Abū Bakr’s caliphate and/or his superiority in Taʼwīlāt al-Qurʼān will be scanned and in this context, the way Māturīdī understands and interprets verses such as al-Maidah 5/54, at-Tawbah 9/40, Hūd 11/84 and al-Hadid 57/19 will be analyzed.
Implications of TRPM3 and TRPM8 for sensory neuron sensitisation
Authors: Behrendt Marc 
Published: September 2024

Abstract
Sensory neurons serve to receive and transmit a wide range of information about the conditions of the world around us as well as the external and internal state of our body. Sensitisation of these nerve cells, i.e. becoming more sensitive to stimuli or the emergence or intensification of spontaneous activity, for example in the context of inflammation or nerve injury, can lead to chronic diseases such as neuropathic pain. For many of these disorders there are only very limited treatment options and in order to find and establish new therapeutic approaches, research into the exact causes of sensitisation with the elucidation of the underlying mechanisms and the identification of the molecular components is therefore essential. These components include plasma membrane receptors and ion channels that are involved in signal reception and transmission. Members of the transient receptor potential (TRP) channel family are also expressed in sensory neurons and some of them play a crucial role in temperature perception. This review article focuses on the heat-sensitive TRPM3 and the cold-sensitive TRPM8 (and TRPA1) channels and their importance in sensitisation of dorsal root ganglion sensory neurons is discussed based on studies related to inflammation and injury- as well as chemotherapy-induced neuropathy.
Solutions to the Schrödinger equation using deep neural networks for integrated photonics
Authors: Dubey Sourabh Kumar , Islahi Hibah , Singh Raghvendra 
Published: September 2024

Abstract
This paper introduces a novel method for solving the Schrödinger equation through the use of deep neural networks (DNNs), presenting a significant departure from traditional techniques. Conventional approaches to solving the Schrödinger equation, such as analytical methods and numerical algorithms, often face challenges when dealing with complex quantum systems due to their inherent limitations. These traditional methods can become cumbersome or even infeasible as the complexity of the systems increases. In contrast, our approach harnesses the capabilities of deep neural networks to approximate both the wavefunction and the energy eigenvalues of quantum systems. By leveraging the flexible and powerful nature of DNNs, we provide a new pathway to solving the Schrödinger equation that can potentially overcome the constraints of classical methods. To validate the effectiveness of our approach, we apply it to the particle in a box problem – a fundamental quantum mechanics model with well-established analytical solutions. This benchmark problem serves as a useful test case, allowing us to demonstrate that DNNs can not only replicate the known results accurately but also offer insights into how these networks can handle more intricate quantum systems. Our results reveal that DNNs are capable of accurately reproducing the analytical solutions for the particle in a box, illustrating their potential as a versatile tool for quantum mechanics.
On Not Speaking
Authors: Lapidot Elad 
Published: September 2024

Abstract
This article explores the challenges of intercultural dialogue between European and non-European epistemologies through a study of Heidegger’s conversation with a Japanese thinker. It discusses the inherent challenges and potential failures in such dialogues, emphasizing the differences in language and thought systems, and concludes by considering the ethical implications of these dialogues and the necessity of an “ethics of not speaking”.
On the Value of Informal Communication in Archaeological Data Work
Authors: Batist Zachary 
Published: September 2024

Abstract
Archaeological data simultaneously serve as formal documentary evidence that supports and legitimizes chains of analytical inference and as communicative media that bind together scholarly activities distributed across time, place, and social circumstance. This contributes to a sense of “epistemic anxiety,” whereby archaeologists require that data be objective and decisive to support computational analysis but also intuitively understand data to be subjective and situated based on their own experiences as participants in an archaeological community of practice. In this article, I present observations of and elicitations about archaeological practices relating to the constitution and transformation of data in three cases in order to articulate this tension and document how archaeologists cope with it. I found that archaeologists rely on a wide variety of situated representations of archaeological experiences – which are either not recorded at all or occupy entirely separate and unpublished data streams – to make sense of more formal records. This undervalued information is crucial for ensuring that relatively local, bounded, and private collaborative ties may be extended beyond the scope of a project and, therefore, should be given more attention as we continue to develop open data infrastructures.
Coding Dynamics of the Striatal Networks During Learning
Authors: Villet Maxime , Reynaud-Bouret Patricia , Poitreau Julien , Baldi Jacopo , Jaffard Sophie , James Ashwin , Muzy Alexandre , Kartsaki Evgenia , Scarella Gilles , Sargolini Francesca , Bethus Ingrid 
Published: September 2024

The rat dorsomedial (DMS) and dorsolateral striatum (DLS), equivalent to caudate nucleus and putamen in primates, are required for goal-directed and habit behaviour, respectively. However, it is still unclear whether and how this functional dichotomy emerges in the course of learning. In this study, we investigated this issue by recording DMS and DLS single neuron activity in rats performing a continuous spatial alternation task, from the acquisition to optimized performance. We first applied a classical analytical approach to identify task-related activity based on the modifications of single neuron firing rate in relation to specific task events or maze trajectories. We then used an innovative approach based on Hawkes process to reconstruct a directed connectivity graph of simultaneously recorded neurons, that was used to decode animal behavior. This approach enabled us to better unravel the role of DMS and DLS neural networks across learning stages. We showed that DMS and DLS display different task-related activity throughout learning stages, and the proportion of coding neurons over time decreases in the DMS and increases in the DLS. Despite these major differences, the decoding power of both networks increases during learning. These results suggest that DMS and DLS neural networks gradually reorganize in different ways in order to progressively increase their control over the behavioral performance.