bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality and prognostic factors among inpatients with systemic lupus erythematosus in China: A 20-year retrospective study
Authors: Dong Fei , Zhao Cheng , Lei Ling , Zheng Leting , Wen Jing , Qin Fang 
Published: September 2024

Objective To summarize the causes of death and clinical characteristics of systemic lupus erythematosus (SLE) hospitalized patients in the last 20 years to improve SLE survival rates by detecting critical SLE early. Methods In this case-control study, 218 SLE death cases were retrospectively analyzed from January 2002 to December 2022, with 110 SLE inpatients chosen at random as controls. The clinical symptoms, causes of death, and risk factors in patients with SLE were investigated. Results There were 218 deaths among 9538 patients with SLE, including 188 women and 30 men. The death rate fell steadily from 4.14% in 2002 to 1.96% in 2013 and remained at 1.84% from 2014 to 2022. The standardized mortality ratio (SMR) was 4.98 [95% CI (4.06-5.89)] from 2002 to 2012 and 3.39 [95% CI (2.74-4.04)] from 2013 to 2022. Infection, lupus-induced multiple organ failure syndrome (MODS), and neuropsychiatric lupus (NPLE) were the leading causes of death, accounting for 31.19%, 15.14%, and 11.47% of overall deaths. Age had a significant association with the major causes of death. Logistic regression analysis showed NPLE[OR = 10.772,95% CI (3.350,34.633), p < 0.001], lupus pulmonary involvement (LP)[OR = 3.844,95%CI (1.547,9.552), p = 0.004], pneumonia[OR = 3.439,95%CI(1.552,7.621), p = 0.002], thrombocytopenia[OR = 14.941,95%CI (4.088,54.604), p < 0.001], creatinine>177 μmol/L[OR = 8.644,95%CI (2.831,26.388), p < 0.001], glutamic transaminase(AST) > 60U/L[OR = 5.762,95%CI (2.200,15.088), p < 0.001], total bilirubin > 34 μmol/L[OR = 16.701,95%CI (3.349,83.294), p = 0.001], higher SLE Disease Activity Index (SLEDAI)[OR = 1.089,95%CI (1.032,1.149), p = 0.002] and SLE Damage Index (SDI)[OR = 3.690,95%CI (2.487,5.474), p < 0.001] correlated positively with death. Conclusion From 2002 to 2013, the mortality rate among patients with SLE fell steadily but remained unchanged from 2014 to 2022. Patients with SLE had significantly higher SMR than the general population. Childhood-onset SLE had a poorer prognosis than adult-onset SLE. Infection, MODS, and NPLE were the three leading causes of death. Major organ involvement and high disease activity were risk factors for mortality.
Added Advantages of DWI MR Imaging and ADC Mapping in the Diagnosis of Active Sacroiliitis of Axial Seronegative SpA
Authors: Boruah Deb K. , Marak Rebecca R. , Gogoi Pallavi , Gogoi Bidyut B. , Phukan Pranjal , Sarma Kalyan , Angiras Shivam , Ahmed Halimuddin 
Published: September 2024

Aim: To evaluate the effectiveness of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping in diagnosing active sacroiliitis in patients with axial seronegative spondyloarthropathy (SpA). Material and Methods: This prospective study comprised 26 patients with MR imaging detected active sacroiliitis categorised as a case group, and compared them with healthy controls. ADC value measurements were obtained from the sacral and iliac sides of the bilateral S.I. joints in each case and control group. Independent samples t-test, Chi-square test, and ROC curve analysis were used. Result: Twenty-six patients had active sacroiliitis in 45 S.I. joints, unilateral active sacroiliitis was observed in seven patients (26.9%), bilateral symmetrical in three patients (11.5%) and bilateral asymmetrical in 16 patients (61.5%). The mean ADC value was 1.447 ± 0.528 [SD] × 10–3 mm 2 /s in the right S.I. joint and 1.630 ± 0.441 [SD] × 10–3 mm 2 /s in the left S.I. joint in active sacroiliitis (case group). The mean ADC value of the right S.I. joint was 0.965 ± 0.123 [SD] × 10–3 mm 2 /s and the left S.I. joint was 0.967 ± 0.96 [SD] × 10–3 mm 2 /s in inactive sacroiliitis (control group). A significant difference was observed statistically between the active sacroiliitis and the inactive sacroiliitis with a P < .0005. A cut-off mean ADC value of 1.034 ×10–3 mm 2 /s was obtained for differentiating active sacroiliitis from inactive sacroiliitis with a sensitivity of 84.6% and specificity of 84.6% from the ROC curve analysis. Conclusion: Diffusion-weighted MRI imaging with ADC value mapping acts as a sensitive diagnostic technique in the detection of active sacroiliitis in axial seronegative spondyloarthropathies and also helps in assessing the treatment response.
Decoding Research with a Glance: The Power of Graphical Abstracts and Infographics
Authors: Jeyaraman Madhan , Jeyaraman Naveen , Ramasubramanian Swaminathan , Vaish Abhishek , Vaishya Raju 
Published: September 2024

Background and Aims: Historically integral to science, visual elements like Darwin’s evolutionary trees have evolved with technological advancements, leading to more sophisticated and accessible visual representations. Graphical abstracts (GA) and infographics (IG) have become pivotal in enhancing the dissemination and understanding of scientific research by transforming complex data into visually engaging summaries. This review explores the evolution, impact, and design principles of these tools in scientific communication, highlighting their significance in the digital era. Methods: We did a comprehensive review of the English literature, in April 2024, from the databases of PubMed, Scopus, Embase, and Google Scholar to curate the appropriate articles related to the GA and IG related to research-publications. We have also made some representative examples of each of these two tools, using published articles in the Apollo Medicine journal. Results: The GA and IG, are the tools that not only aid in bridging the gap between scientific communities and the public but also enhance comprehension, engagement, and retention of information across diverse audiences. By utilising strategic layouts, colours, and interactive elements, they make complex information more digestible and appealing. Conclusion: This review addresses the challenges of maintaining accuracy and avoiding oversimplification in visual science communication. The future directions suggest a move towards more interactive and immersive visual experiences, emphasising the need for empirical research to optimise design and impact. GA and IG are transforming scientific communication by making research findings more accessible and engaging, fostering a better-informed public.
Imaging evaluation of extraarticular posterior loose bodies in varus ankle osteoarthritis
Authors: Song Tae Hun , Choi Jun Young , Suh Jin Soo , Suh Yu Min , Chun Kyung Ah 
Published: September 2024

Purpose: Multiple loose bodies (LBs) are often found in patients with varus ankle osteoarthritis (OA). This study aimed to investigate the characteristics of extra-articular posterior ankle LBs in patients with varus ankle OA. We also sought to determine whether there were variations in the characteristics of LBs according to the degree of ankle OA. Methods: We retrospectively reviewed 50 patients who had appeared posterior extraarticular LBs on preoperative ankle imaging among the patients who underwent operative treatment for varus ankle OA from March 2011 to February 2023. We categorized the entire patient cohort into four groups according to the degree of ankle arthritis (Takakura stage II, IIIA, IIIB, and IV). Size, number, and location of LBs were evaluated using preoperative computed tomography and magnetic resonance imaging. Results: 142 LBs were identified (mean size: 11.5 mm); 76.8% were located within the flexor hallucis longus (FHL) tendon sheath, 20.4% in the posterior recess, and 2.8% in the flexor digitorum longus tendon sheath. Average LB size was significantly larger in Takakura stage IIIB and IV patients ( p < .05), and the LB number was significantly lower in stage II patients ( p = .013). Conclusion: Extra-articular posterior LBs in varus ankle OA are predominantly located within the FHL tendon sheath and were larger in Takakura stages IIIB and IV patients. Level of Evidence: Level III. Retrospective comparative study.
Characterising the nature of psychiatric disorders and patterns of antipsychotic medications prescribed in a psychiatric ward in a public hospital in Tasmania
Authors: Tamrakar Sharad , Mendoza Diaz Antonio , Nevarez Flores Adriana G , Castle David 
Published: September 2024

Objective We present an evaluation of antipsychotic prescribing in an inpatient psychiatry ward in Hobart, Tasmania, to establish pattern of use, alignment with other psychiatric wards or centres and the recommendations in the Royal Australian and New Zealand College of Psychiatry Clinical Practice Guidelines, and to determine predictors of polypharmacy. Methods A descriptive cross-sectional survey design was used. Data from 118 patients discharged from the Royal Hobart Hospital (RHH) Mental Health Inpatient Unit between 01/02/2021 to 01/08/2021 were evaluated. Results Antipsychotic polypharmacy (APP) was observed in 40% of patients. When low doses of adjunctive (‘PRN’) use of olanzapine and quetiapine were excluded, the APP proportion was 35%. APP was predicted by age and by a schizophrenia diagnosis. Long-acting injections (LAIs) were used in 46% of the patients. The most common LAI was risperidone (52%). Average daily dose of antipsychotic at the time of discharge was 529 mg chlorpromazine (CPZ) equivalents. High dose antipsychotics (more than 1000 mg CPZ equivalents per day) was observed in 13% of the patients. Conclusions The observed prescribing practice is consistent with other clinical settings. Antipsychotic prescribing practice should, however, continue to be monitored to ensure adherence to best practice guidelines.
Psychosocial workplace safety in mental health services – Commentary and considerations to improve safety
Authors: Looi Jeffrey CL , Maguire Paul A , Kisely Steve , Allison Stephen , Bastiampillai Tarun 
Published: September 2024

Objectives Psychosocially unsafe workplaces are related to burnout, especially amongst trainees and psychiatrists. Burgeoning research on psychosocial workplace safety indicates the importance of organisational governance to reduce adverse professional, and consequently patient, outcomes in healthcare by balancing job demands and resources. We provide a brief commentary on the relevance of the concept of the Psychosocial Safety Climate model for mental health services and healthcare workers, and considerations for action. Conclusions Based on the Extended Job Demand-Resource model, the Psychosocial Safety Climate model has been developed and validated in community and healthcare environments. Psychosocial safety is also an Australian workplace safety requirement. An important direction to improve working conditions, reduce adverse outcomes, and improve recruitment and retention of healthcare workers, may be to adopt and formalise psychosocial workplace safety as a key performance indicator of equal importance to productivity for mental healthcare services.
The Impact of Social Determinants of Health and Acculturation on Quality of Life in Older Chinese American Adults With Chronic Pain: A Quantitative Study
Authors: Lam Chi , Cuellar Norma 
Published: September 2024

Introduction: As of 2019, the United States houses 5.3 million Chinese Americans (CA), with 689,000 being older adults. The purpose of this study was to examine the relationships between social determinants of health (SDOH) and acculturation on quality of life in CA older adults, an underresearched area. Methods: Using a quantitative correlational descriptive design, CA older adults ( n = 110) in NYC with chronic pain were examined. Data were collected by utilizing the PRAPARE Screening Tool, Asian American Acculturation Scale, and SF-12 Questionnaire. Results: Regression revealed a negative correlation between SDOH and quality of life ( p = .001). The acculturation’s impact was nonsignificant ( p = .647). Discussion: While SDOH significantly impacted the quality of life, acculturation did not significantly predict the quality of life for older Chinese American adults with chronic pain. Further research is warranted to explore the nuanced dynamics between acculturation, SDOH, and quality of life in this population.
An Assessment of Adverse Events in Patients with 22q11.2 Deletion Syndrome Undergoing Palatoplasty: An Analysis of the NSQIP Pediatric Database
Authors: Bergman Hannah J. , Asti Lindsey , Kirschner Richard E. 
Published: September 2024

Background The National Surgical Quality Improvement Program (NSQIP) Pediatric database has been used to identify factors related to adverse surgical outcomes in pediatric and craniofacial surgical procedures. Focusing on a historically “higher-risk” population, our aim was to assess the impact of demographics, comorbidities, and 22q11.2 deletion syndrome (22QDS) diagnosis on 30-day postoperative complications in patients undergoing primary palatoplasty. Methods We used the 2012–2020 NSQIP Pediatric database to identify patients ≤3 years with and without 22q11.2 deletion syndrome who underwent primary palatoplasty. Demographics, comorbidities, and perioperative characteristics were compared between those with and without 22QDS. Logistic regression was used to determine if children with 22QDS were more likely to experience a 30-day postoperative complication or readmission. Results There were 10,745 patients ≤3 years old who underwent primary palatoplasty; 83 (0.8%) of whom had 22QDS and 10,662 (99.8%) did not. Children with 22QDS were older when they underwent primary palatoplasty and more likely to have comorbidities. A total of 513 patients (4.8%) experienced a postoperative complication within 30 days and 255 were readmitted (2.4%). Of the 513, 8 (9.6%) had a 22QDS diagnosis and 505 (4.7%) did not. A diagnosis of 22QDS was not a significant independent risk factor for a complication (adjusted odds ratio (aOR) = 1.13; 95% confidence interval (CI): 0.50–2.54) or readmission (aOR = 1.74; 95% CI: 0.74–4.13) within 30 days. Conclusion This study found that the diagnosis of 22QDS was not an independent predictor of post-palatoplasty complication risk, and in fact 30-day complications are rare for those patients undergoing cleft palate repair, even among those patients with 22QDS.
Long-Term Surgical Outcomes of Primary Rhinoplasty
Authors: Ng Jinggang J , Banala Manisha , Massenburg Benjamin B , Romeo Dominic J , Wu Meagan , Jackson Oksana A , Low David W , Bartlett Scott P , Swanson Jordan W , Taylor Jesse A 
Published: September 2024

Objective To examine the impact of primary rhinoplasty on subsequent rhinoplasties for patients with cleft lip nasal deformity. Design Retrospective cohort study. Setting Tertiary care pediatric hospital. Patients/Participants Individuals who underwent definitive cleft lip repair at our institution from 2000 to 2006 with a current age of 18 or older. Main Outcome Measures Number and timing of subsequent rhinoplasties. Results Among 199 individuals, 94 (47.2%) underwent primary rhinoplasty. Follow-up was 15.0 ± 4.8 years in the PR cohort and 15.0 ± 5.1 years in the NPR cohort ( p = 0.993). In bilateral cleft lip, interdomal suture predicted fewer subsequent rhinoplasties (β=-0.310, p = 0.033), while history of primary rhinoplasty predicted greater age at subsequent rhinoplasty (β=1.800, p = 0.040). Among individuals with follow-up beyond age 18, intranasal stenting predicted fewer subsequent rhinoplasties (β=-0.609, p = 0.015). Most underwent subsequent nasal correction aside from 7 (19.4%) and 9 (20.9%) in the PR and NPR cohorts, respectively ( p = 0.536). There was no difference in mean subsequent rhinoplasties between cohorts (1.1 ± 0.8 versus 1.3 ± 1.1, p = 0.284). Individuals with complete cleft lip underwent more lifetime rhinoplasties (1.9 ± 1.0 versus 1.2 ± 1.2, p = 0.007). Conclusions Primary rhinoplasty with interdomal tip sutures in bilateral cleft lip was associated with fewer subsequent rhinoplasties. Primary rhinoplasty may delay subsequent nasal correction, though most who underwent primary rhinoplasty ultimately required nasal correction later in childhood. Postoperative nasal stenting may provide longer-term nasal benefits and should be considered at time of definitive cleft lip repair.
Vascular Anomalies and Congenital Infiltrating Lipomatosis May Affect Dental Maturation and Development – a Case Control Study
Authors: Leinonen Sami , Vuola Pia , Rice David P , Heliövaara Arja 
Published: September 2024

Objective Vascular anomalies are often associated with hypertrophy and asymmetry of soft tissues and bony structures. The aim of this retrospective cross-sectional radiographic study was to evaluate dental maturation and development in patients with facial vascular anomalies and congenital infiltrating lipomatosis. Design A sample of 342 patients with different vascular anomalies or congenital infiltrating lipomatosis involving the head and neck area was narrowed down to 31 patients with dental panoramic radiographs taken in the mixed dentition. A control group of 172 age-matched healthy subjects was used. Individual permanent teeth were given a maturation score from 1 to 12 and alveolar eruption stage according to Haavikko et al. 1970. The laterality of the anomaly was noted if applicable. Differences in dental development between affected and unaffected sides were recorded. Results The study data included both syndromic and non-syndromic vascular anomalies as well as congenital infiltrating lipomatosis and segmental odontomaxillary dysplasia. Teeth on the side of the anomaly were more developed and the eruption of teeth was accelerated with canines, premolars and second molars being most affected. Interestingly all the patients with Sturge-Weber syndrome (n = 4) and infiltrating lipomatosis (n = 2) showed accelerated dental maturation of multiple permanent teeth on the side of the anomaly. Hypodontia, dental root resorption and macrodontia were also found. Conclusions Accelerated development and eruption of permanent teeth unilaterally in patients with vascular anomalies and congenital infiltrating lipomatosis may have a significant impact on the developing occlusion and should be thus followed by an orthodontist.
Long Noncoding RNAs MALAT1 and HOTTIP Act as Serum Biomarkers for Hepatocellular Carcinoma
Authors: Bao Han , Jiang Yutian , Wang Ning , Su Hongying , Han Xiangjun 
Published: September 2024

Background Circulating tumor markers with satisfactory sensitivity and specificity play crucial roles in cancer diagnosis and therapy. This prospective study aimed to evaluate the potential of circulating lncRNAs as biomarkers for hepatocellular carcinoma (HCC). Methods A total of 74 patients with HCC and 94 healthy controls were enrolled. The expression levels of candidate genes in serum were detected by qRT-PCR. Receiver operating characteristic (ROC) curve analysis and logistic regression were employed to investigate the diagnostic capacity of lncRNAs. The analysis of 3-year overall survival (OS) was conducted using the Kaplan-Meier method and log-rank test. Results Of the 9 candidate genes, 6 lncRNAs could be stably detected in serum. The expression levels of circulating MALAT1 and HOTTIP in HCC patients were significantly higher than those in controls ( P < 0.001). ROC analysis showed that MALAT1 and HOTTIP were more effective than alpha-fetoprotein (AFP) ( P < 0.010) in the diagnosis of HCC, with AUCs of 0.896 and 0.899, respectively. Additionally, a panel consisting of MALAT1, HOTTIP, and AFP was constructed to obtain an AUC of 0.968 with a sensitivity of 87.8% and specificity of 94.7% in HCC diagnosis. Moreover, the upregulation of MALAT1 was not only related to multiple tumor lesions, HCV infection, AST level, and AFP level, but also suggested shorter OS. A high expression level of HOTTIP was associated with metastasis. Conclusion Serum MALAT1 and HOTTIP play indicative roles as non-invasive biomarkers for HCC.
Multicenter randomized controlled trial to assess the effectiveness of PASSEO-LUX DCB® drug coated balloon compared to plain balloon angioplasty of arteriovenous fistulae for hemodialysis: Two-years results
Authors: Moreno-Sánchez Teresa , Moreno-Ramírez Manuela , Machancoses Francisco H 
Published: September 2024

Purpose: To compare primary patency after angioplasty with drug-coated balloon (DCB)-Passeo-18Lux, BIOTRONIK versus uncoated balloon in dysfunctional peripheral vascular access (PVA) for hemodialysis. Material and methods: A total of 133 patients from four hospitals were randomized to receive DCB or plain old balloon angioplasty (POBA) after satisfactory treatment (residual stenosis <30%) with high pressure balloon (HPB). The primary endpoint was clinical patency of PVA 2 years after angioplasty. Secondary endpoints included the relationship between the location of stenosis and patency and also, other covariates. Mortality at 2 years was compared between both groups. Results: Patency measured in days after angioplasty was higher in fistulae dilated with DCB than HPB. Kaplan-Meier survival curves showed the next percent of success (free time restenosis) after DCB versus POBA at 6 months—77.1% versus 58.2% (160.41–143.72 days until restenosis), 12 months—51.4% versus 44.3% (274.1–237.23), 18 months—38.6% versus 38% (350.74–305.18), and 24 months—37.1% versus 30.4% (419.04–369.1). At 6 months, this difference was statistically significant ( p = 0.018), but not at 12 ( p = 0.225), 18 ( p = 0.471), or 24 months ( p = 0.236). Mortality was similar in both groups. Conclusions: DCB angioplasty resulted in superior target lesion primary patency (TLPP)-free survival at 6 months of follow-up. No significant improvements in TLPP-free survival long term were observed. Mortality observed at 1 and 2 years was similar in DCB and POBA: there was no significant difference, and a safety study demonstrated no difference between the two groups (complications and mortality): DCB is safe to use in stenosis treatment in patients who are PVA carriers. Level of evidence: Level Ia, therapeutic study, RCT. EBM ratings will be based on a scale of 1–5.