bluuebunny/crossref_metadata_2025_split huggingface dataset:
A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies
Authors: Nachbagauer Raffael , Liu Wen-Chun , Choi Angela , Wohlbold Teddy John , Atlas Talia , Rajendran Madhusudan , Solórzano Alicia , Berlanda-Scorza Francesco , García-Sastre Adolfo , Palese Peter , Albrecht Randy A. , Krammer Florian 
Published: August 2017

AbstractInfluenza viruses evade human adaptive immune responses due to continuing antigenic changes. This makes it necessary to re-formulate and re-administer current seasonal influenza vaccines on an annual basis. Our pan-influenza vaccination approach attempts to redirect antibody responses from the variable, immuno-dominant hemagglutinin head towards the conserved—but immuno-subdominant—hemagglutinin stalk. The strategy utilizes sequential immunization with chimeric hemagglutinin-based vaccines expressing exotic head domains, and a conserved hemagglutinin stalk. We compared a live-attenuated influenza virus prime followed by an inactivated split-virus boost to two doses of split-virus vaccines and assessed the impact of adjuvant on protection against challenge with pandemic H1N1 virus in ferrets. All tested immunization regimens successfully induced broadly cross-reactive antibody responses. The combined live-attenuated/split virus vaccination conferred superior protection against pandemic H1N1 infection compared to two doses of split-virus vaccination. Our data support advancement of this chimeric hemagglutinin-based vaccine approach to clinical trials in humans.
Intertidal marine sediment harbours Actinobacteria with promising bioactive and biosynthetic potential
Authors: Jose Polpass Arul , Jha Bhavanath 
Published: August 2017

AbstractActinobacteria are the major source of bioactive natural products that find their value in research and drug discovery programmes. Antimicrobial resistance and the resulting high demand for novel antibiotics underscore the need for exploring novel sources of these bacteria endowed with biosynthetic potential. Intertidal ecosystems endure regular periods of immersion and emersion, and represent an untapped source of Actinobacteria. In this study, we studied the diversity and biosynthetic potential of cultivable Actinobacteria from intertidal sediments of Diu Island in the Arabian Sea. A total of 148 Actinobacteria were selectively isolated using a stamping method with eight isolation media. Isolates were grouped into OTUs based on their 16S rRNA gene sequence, and categorized within actinobacterial families such as Glycomycetaceae, Micromonosporaceae, Nocardiaceae, Nocardiopsaceae, Pseudonocardiaceae, Streptomycetaceae, and Thermomonosporaceae. The biosynthetic potential of the Actinobacteria, necessary for secondary metabolite biosynthesis, was screened and confirmed by extensive fingerprinting approaches based on genes coding for polyketide synthases and nonribosomal peptide synthetases. The observed biosynthetic potential was correlated with the antibacterial activity exhibited by these isolates in laboratory conditions. Ultimately, the results demonstrate that intertidal sediment is a rich source of diverse cultivable Actinobacteria with high potential to synthesize novel bioactive compounds in their genomes.
Tribochemistry of adaptive integrated interfaces at boundary lubricated contacts
Authors: Wan Shanhong , Tieu Anh Kiet , Xia Yana , Wang Liping , Li Dongshan , Zhang Guangan , Zhu Hongtao , Tran Bach H. , Mitchell David R. G. 
Published: August 2017

AbstractUnderstanding how an adaptive integrated interface between lubricant additives and solid contacts works will enable improving the wear and friction of moving engine components. This work represents the comprehensive characterization of compositional and structural orientation at the sliding interface from the perspective of surface/interface tribochemistry. The integrated interface of a lubricant additive-solid resulting from the friction testing of Graphite-like carbon (GLC) and PVD-CrN coated rings sliding against cast iron under boundary lubrication was studied. The results indicate that in the case of the CrN/cast iron pair the antiwear and friction behavior were very strongly dependent upon lubricant. In contrast, the tribology of the GLC surface showed a much lower dependence on lubrication. In order to identify the compounds and their distribution across the interface, x-ray microanalysis phase mapping was innovatively applied and the principle of hard and soft acids and bases (HSAB) to understand the behaviour. Phase mapping clearly showed the hierarchical interface of the zinc-iron polyphosphate tribofilm for various sliding pairs and different sliding durations. This interface structure formed between lubricant additives and the sliding surfaces adapts to the sliding conditions – the term adaptive interface. The current results help explain the tribology of these sliding components in engine.
MTOPVIB interacts with AtPRD1 and plays important roles in formation of meiotic DNA double-strand breaks in Arabidopsis
Authors: Tang Yu , Yin Zhongnan , Zeng Yuejuan , Zhang Qinxin , Chen Liqun , He Yan , Lu Pingli , Ye De , Zhang Xueqin 
Published: August 2017

AbstractMeiotic recombination is initiated from the formation of DNA double-strand breaks (DSBs). In Arabidopsis, several proteins, such as AtPRD1, AtPRD2, AtPRD3, AtDFO and topoisomerase (Topo) VI-like complex, have been identified as playing important roles in DSB formation. Topo VI-like complex in Arabidopsis may consist of subunit A (Topo VIA: AtSPO11-1 and AtSPO11-2) and subunit B (Topo VIB: MTOPVIB). Little is known about their roles in Arabidopsis DSB formation. Here, we report on the characterization of the MTOPVIB gene using the Arabidopsis mutant alleles mtopVIB-2 and mtopVIB-3, which were defective in DSB formation. mtopVIB-3 exhibited abortion in embryo sac and pollen development, leading to a significant reduction in fertility. The mtopVIB mutations affected the homologous chromosome synapsis and recombination. MTOPVIB could interact with Topo VIA proteins AtSPO11-1 and AtSPO11-2. AtPRD1 interacted directly with Topo VI–like proteins. AtPRD1 also could interact with AtPRD3 and AtDFO. The results indicated that AtPRD1 may act as a bridge protein to interact with AtPRD3 and AtDFO, and interact directly with the Topo VI-like proteins MTOPVIB, AtSPO11-1 and AtSPO11-2 to take part in DSB formation in Arabidopsis.
Highly wear-resistant and low-friction Si3N4 composites by addition of graphene nanoplatelets approaching the 2D limit
Authors: Tapasztó Orsolya , Balko Ján , Puchy Viktor , Kun Péter , Dobrik Gergely , Fogarassy Zsolt , Horváth Zsolt Endre , Dusza Ján , Balázsi Katalin , Balázsi Csaba , Tapasztó Levente 
Published: August 2017

AbstractGraphene nanoplatelets (GNPs) have emerged as one of the most promising filler materials for improving the tribological performance of ceramic composites due to their outstanding solid lubricant properties as well as mechanical and thermal stability. Yet, the addition of GNPs has so far enabled only a very limited improvement in the tribological properties of ceramics, particularly concerning the reduction of their friction coefficient. This is most likely due to the challenges of achieving a continuous lubricating and protecting tribo-film through a high GNP coverage of the exposed surfaces. Here we demonstrate that this can be achieved by efficiently increasing the exfoliation degree of GNPs down to the few-layer (FL) range. By employing FL-GNPs as filler material, the wear resistance of Si3N4 composites can be increased by more than twenty times, the friction coefficient reduced to nearly its half, while the other mechanical properties are also preserved or improved. Confocal Raman spectroscopy measurements revealed that at the origin of the spectacular improvement of the tribological properties is the formation of a continuous FL- GNP tribo-film, already at 5 wt% FL-GNP content.
How spontaneous brain activity and narcissistic features shape social interaction
Authors: Scalabrini Andrea , Huang Zirui , Mucci Clara , Perrucci Mauro Gianni , Ferretti Antonio , Fossati Andrea , Romani Gian Luca , Northoff Georg , Ebisch Sjoerd J. H. 
Published: August 2017

AbstractThere is an increasing interest in how ongoing spontaneous brain activity and personality provide a predisposition for the processing of environmental demands. It further has been suggested that the brain has an inherent sensitivity to the social environment. Here we tested in healthy volunteers if spontaneous brain activity contributes to a predisposition for social behavior and how this is modulated by narcissistic personality features associated with poor interpersonal functioning. Functional magnetic resonance imaging included a resting state and an experimental paradigm focusing on the anticipation of actively touching an animate (human hand) versus an inanimate target (mannequin hand). The experimental task induced a significant modulation of neural activity in left postcentral gyrus (PostCG), right culmen and, co-varying with narcissistic features, in right anterior insula (AI). Neural activity in anticipation of the animate target significantly correlated with spontaneous activity during the resting state indexed by the Power Law Exponent (PLE) in PostCG and AI. Finally, the correlation between spontaneous and task-induced activity in AI was mediated by narcissistic features. These findings provide novel evidence for a relationship between intrinsic brain activity and social behavior and show how personality could contribute to individual differences in our predisposition to approach the animate world.
Recent Advances on the Application of Electrocyclic Reactions in Complex Natural Product Synthesis
Authors: Bian Ming , Ding Hanfeng , Li Lekai 
Published: August 2017

The electrocyclic reaction is one of the most powerful tools for the construction of complex polycyclic scaffolds in a highly stereocontrolled fashion. In this review, recent advances in its application in the total synthesis of representative natural products are discussed, with the aim of providing a complement to existing reviews.1	Introduction2	4π Electrocyclization2.1	Neutral 4π Electrocyclization2.2	Cationic 4π Electrocyclization3	6π Electrocyclization3.1	All-Carbon 6π Electrocyclization3.2	Oxa-6π Electrocyclization3.3	Aza-6π Electrocyclization3.4	Retro-6π Electrocyclization4	8π Electrocyclization5	Conclusion and Outlook
TBI and Sleep–Wake Disorders: Pathophysiology, Clinical Management, and Moving towards the Future
Authors: Baumann Christian , Werner J. 
Published: August 2017

After experiencing a traumatic brain injury (TBI), the majority of patients will develop sleep–wake disorders (SWD). These can include insomnia, pleiosomnia, excessive daytime sleepiness, obstructive and/or central sleep apnea, circadian sleep–wake disorders, and potentially a variety of parasomnias. Untreated SWD may impede the recovery process and can negatively impact attention, executive function, and working memory. Importantly, these patients tend to misperceive their posttraumatic sleep problems. Consequently, interviews performed in standard clinical practice will not sufficiently capture SWD patients, potentially compromising safety and productivity.In this review, the authors outline the state of current TBI-related SWD, highlighting proposed mechanisms, treatment modalities, and areas for further clinical investigation. They highlight data examining a role for slow wave sleep (SWS) in the enhancement of neural repair. They also examine the utility of enhanced cohort recruitment and SWD biomarker discovery via use of social media, smart-devices, and data-sharing networks.
Chronic Insomnia
Authors: Bianchi Matt 
Published: August 2017

AbstractInsomnia is characterized by difficulty falling asleep or staying asleep, with consequent daytime impairment of mental and/or physical function. A detailed clinical history reveals the relative impact of a variety of different contributing and perpetuating factors, which then informs prioritization among different treatment options. Nonpharmacological approaches, especially the validated approach of cognitive–behavioral therapy for insomnia, are preferred over hypnotic medications. If hypnotics are chosen, the goal is short-term interventions after a careful risk-benefit assessment and shared decision-making with the patient. Although objective testing via polysomnography is not routinely indicated, such investigations can be informative in those at risk for concurrent primary sleep disorders, and in those who are treatment refractory. Circadian rhythm disorders can present with insomnia complaints, but are managed with chronotherapy. Whatever management pathway is pursued, the response to therapy should be anchored in improvements in daytime function.
A Single-Center Experience with Very Low Birth Weight Infants and Focal Intestinal Perforation: Comparison of Primary Anastomosis versus Stoma Opening
Authors: Consonni Dario , Macchini Francesco , Parente Giovanni , Zanini Andrea , Franzini Stefania , Colnaghi Mariarosa , Mosca Fabio , Leva Ernesto , Brisighelli Giulia 
Published: August 2017

Introduction We present a single-center experience with very low birth weight (VLBW) infants with focal intestinal perforation (FIP), comparing the results of primary anastomosis (PA) and stoma opening (SO).
Materials and Methods Clinical records of VLBW infants with FIP who underwent surgery between 2006 and 2015 were reviewed. Patients were divided into two groups according to the procedure performed: limited bowel resection and PA or SO. Patients with gastric perforation or patients who underwent clip and drop were excluded. Information regarding birth weight (BW), gestational age (GA), weight at surgery (WS), number of abdominal reoperations, duration of parenteral nutrition (PN), and demise was recorded.
Results In this study, 40 patients were included: 22 in PA group and 18 in SO group. BW was 865 g in PA and 778 in SO (p-value: 0.2). GA was 26.1 weeks in PA and 25.6 in SO (p-value: 0.3). WS was 1,014 g in PA and 842 in SO (p-value: 0.09). Duration of surgery was 115 minutes in PA and 122 in SO (p-value: 0.67). Five patients (23%) belonging to PA group developed complications and required SO. Five patients (23%) demised in PA group and six (33%) in SO (p-value: 0.2). Seventeen abdominal reoperations were performed in PA group and 22 in SO group (p-value: 0.08).
Conclusion Both procedures appear to be safe. When possible, PA should be performed as it reduces the number of abdominal reinterventions.
Role of Early Pulmonary Hypertension as a Risk Factor for Late Pulmonary Hypertension in Extremely Preterm Infants
Authors: Kaluarachchi Dinushan , Woo Kaitlin , Colaizy Tarah 
Published: August 2017

Objective The evidence on the role of early pulmonary vascular disease (PVD) in the development of late pulmonary hypertension (PH) in the extremely preterm infants is limited. Objectives were to determine the incidence of early and late PH in extreme preterm infants and to evaluate the role of early PH as a risk factor for development of clinically detected late PH.
Methods It was a retrospective analysis of early echocardiograms (day of life 5–14) in preterm infants, 22 to 27 weeks' gestation, admitted to the University of Iowa NICU between July 01, 2012 to June 30, 2015. Late echocardiograms performed for clinical suspicion of PH were also analyzed.
Results A total of 154 infants were included in the study. Early PH was diagnosed in 31 (20%) infants. Twenty-four (16%) infants were evaluated for clinically suspected PH. Eight (5%) infants were diagnosed with late PH. Infants with early PH had echocardiograms performed earlier than infants without the evidence of early PH. Early PH was not associated with the development of late PH (p = 0.99).
Conclusion Early PH is common among extremely preterm infants (20%). Five percent of infants had clinically detected late PH. Infants with early PH had echocardiograms performed earlier than infants without the evidence of early PH. Early PH was not associated with the development of clinically detected late PH.
Maternal–Fetal Medicine Physician and Fellow Perceptions of Business in Medicine
Authors: Iriye Brian , Ghamsary Mark , Porter Blake 
Published: August 2017

Objective Principles of practice management provide a foundation for clinical success and performance improvement. Scant data exist regarding maternal–fetal medicine (MFM) physicians' knowledge of these topics. We hypothesize that physicians enter practice with inadequate education in practice management.
Study Design Surveys were emailed to members of the Society for Maternal–Fetal Medicine rating their knowledge and capabilities in practice management topics, and respondents assessed their current institution's business in the medical curriculum.
Results A total of 325 (14.4%) physicians responded: 63 fellows in training and 262 MFM physician subspecialists. Practicing physicians reported learning most of their knowledge “in practice after fellowship” (85%) or “never at all” (10%). Only 3% of respondents had adequate business education during fellowship, and only 5% felt prepared to teach business principles. However, 85% of those surveyed agreed that this material should be taught during the fellowship. Among MFM subspecialists and fellows in training at institutions with fellowships, 60% reported no current curriculum for practice management, and those with current curricula reported it had “limited” or “no value” (76%).
Conclusion There is a significant desire for practice management curricula during MFM fellowship, and current training is insufficient. With many MFM physicians ill-prepared to teach these principles, professional education from other financial fields, and standardized education in practice management from current expert sources is needed.
Frührehabilitation ist erstes Glied einer nahtlosen Rehabilitationskette
Authors: Beyer Joachim , Seidel Egbert 
Published: August 2017

ZusammenfassungEine frühe, intensive rehabilitative Therapie beschleunigt die Wiederherstellung von Funktionen schwerbetroffener Patienten. Sie trägt zu einer Verminderung der Komplikationsrate sowie zu einer Verbesserung der körperlichen und sozialen Funktionsfähigkeit bzw. Teilhabe im Langzeit-Follow-up bei. Die Frührehabilitation muss aufbauend auf den bestehenden Strukturen gestärkt werden: Schaffung und Erhaltung adäquat qualifizierter Frührehabilitationseinrichtungen mindestens in Krankenhäusern mit Schwerpunkt- und Maximalversorgungsaufträgen. Die Patienten mit Langzeitintensivbehandlung und Polytrauma müssen frühestmöglich rehabilitativ erreicht werden (intensivmedizinische Rehabilitation).Fachärzte für Physikalische und Rehabilitative Medizin, rehabilitativ arbeitende Geriater, Neurologen, Orthopäden und Unfallchirurgen und andere Gebietsärzte müssen zielgerichtet zusammenwirken. Ausschlusskriterien über entsprechende OPS-Codes müssen aufgehoben werden. Weitere Gebietsärzte (Anästhesisten und Intensivmediziner, Allgemeinmediziner, Unfall- und Thoraxchirurgen, Internisten) müssen für die Bedeutung der Frührehabilitation sensibilisiert werden.In den länderspezifischen Bettenbedarfsplänen sollten 5 % der Krankenhausbetten (ca. 25 000 von ca. 500 000) als alters- und diagnoseunabhängige Frührehabilitationsbetten ausgewiesen sein. Eine kostendeckende Finanzierung der zweifelsfrei personal- und kostenintensiven Frührehabilitation muss gewährleistet sein. Ein Phasenmodell, analog dem Modell der BAR zur neurologischen-neurochirurgischen Frührehabilitation sollte für weitere Krankheitsentitäten geschaffen werden.Um den Rehabilitationsprozess möglichst erfolgreich zu gestalten, müssen medizinische (Akut-)Behandlung, medizinische Rehabilitation, berufliche Eingliederung und soziale Integration als ganzheitliches Geschehen verstanden werden und wirksam ineinandergreifen, als kontinuierlicher, die gesamte Krankheit phasenhaft begleitender Prozess. Hierzu ist ein kontinuierliches Case Management bzw. eine Reha-Begleitung zu etablieren.
PENTACLE: Parallelized particle–particle particle-tree code for planet formation
Authors: Iwasawa Masaki , Oshino Shoichi , Fujii Michiko S. , Hori Yasunori 
Published: August 2017

Abstract
We have newly developed a parallelized particle–particle particle-tree code for planet formation, PENTACLE, which is a parallelized hybrid N-body integrator executed on a CPU-based (super)computer. PENTACLE uses a fourth-order Hermite algorithm to calculate gravitational interactions between particles within a cut-off radius and a Barnes–Hut tree method for gravity from particles beyond. It also implements an open-source library designed for full automatic parallelization of particle simulations, FDPS (Framework for Developing Particle Simulator), to parallelize a Barnes–Hut tree algorithm for a memory-distributed supercomputer. These allow us to handle 1–10 million particles in a high-resolution N-body simulation on CPU clusters for collisional dynamics, including physical collisions in a planetesimal disc. In this paper, we show the performance and the accuracy of PENTACLE in terms of $\tilde{R}_{\rm cut}$ and a time-step Δt. It turns out that the accuracy of a hybrid N-body simulation is controlled through $\Delta t / \tilde{R}_{\rm cut}$ and $\Delta t / \tilde{R}_{\rm cut} \sim 0.1$ is necessary to simulate accurately the accretion process of a planet for ≥106 yr. For all those interested in large-scale particle simulations, PENTACLE, customized for planet formation, will be freely available from https://github.com/PENTACLE-Team/PENTACLE under the MIT licence.
Neuraxial Analgesia to Increase the Success Rate of External Cephalic Version: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Magro-Malosso E.R. , Saccone G. , Di Tommaso M. , Mele M. , Berghella V. 
Published: August 2017

(Am J Obstet Gynecol. 2016;215(3):276–286)
The objective of this study was to gauge the effectiveness of neuraxial analgesia in increasing the success rate of external cephalic version. Breech or transverse presentations of the fetus is one of the most common causes for the increased cesarean delivery rate. External cephalic version is a medical technique in which the malpresenting fetus is externally manipulated to assume the cephalic birth position.
Antenatal Corticosteroids for Maturity of Term or Near Term Fetuses: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Saccone Gabriele , Berghella Vincenzo 
Published: August 2017

(BMJ. 2016;355:i5044)
One of the significant causes of early neonatal morbidity and mortality in the United States is respiratory distress syndrome (RDS). The use of prophylactic corticosteroids in preterm pregnancies is known to hasten lung maturation and decrease the occurrence of RDS.
Persistent Opioid Use Following Cesarean Delivery: Patterns and Predictors Among Opioid-naive Women
Authors: Bateman B.T. , Franklin J.M. , Bykov K. , Avorn J. , Shrank W.H. , Brennan T.A. , Landon J.E. , Rathmell J.P. , Huybrechts K.F. , Fischer M.A. , Choudhry N.K. 
Published: August 2017

(Am J Obstet Gynecol. 2016;215(3):353.e1–353.e18)
According to the US Centers for Disease Control and Prevention and other leading health care organizations, between 1999 and 2010 the rate of opioid medication overdose resulting in death among women increased 5-fold. With over a third of all deliveries in the United States being cesarean deliveries and opioids being prescribed as postsurgical analgesics to these patients, the risk of overdose increases. Hence, the purpose of this study was to identify the risks and behavior patterns of women with initial opioid exposure (opioid-naive women) in the setting of routine medical care (eg, postcesarean pain medicine prescriptions) associated with them becoming persistent opioid users.