bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cortactin and phosphorylated cortactin tyr421 and tyr466 expression in supraglottic laryngeal carcinomas and lymph node metastases
Authors: Marioni Gino , Lionello Marco , Marchese-Ragona Rosario , Fasanaro Elena , Valentini Elisa , Zanoletti Elisabetta , Stritoni Paola , Ramacciotti Giulia , Guzzardo Vincenza , Giacomelli Luciano , Ralli Giovanni , Ottaviano Giancarlo , Blandamura Stella 
Published: September 2017

Background: The most important adverse prognostic factor for laryngeal squamous cell carcinoma (LSCC) is the presence of cervical lymph node metastases. The supraglottic area of the larynx is richly supplied with lymphatics, and 25%-75% of supraglottic carcinomas metastasize in neck lymph nodes. Cortactin is a multidomain protein related to actin cytoskeleton regulation, podosome and lamellipodia formation, integrin signaling, axon guidance and extracellular matrix degradation. Cortactin is involved in metastasis formation because of its role in cell mobility. The present study focused mainly on the role of cortactin and phosphorylated cortactin (residues tyr421 and tyr466) expression and subcellular localization in primary supraglottic LSCCs and their cervical lymph node metastases. Methods: The immunohistochemical expression of cortactin, p-Y466-cortactin and p-Y421-cortactin was assessed in 38 primary supraglottic LSCCs and 10 lymph node metastases. The statistical approach included bootstrapping analysis. Results: Despite a significantly higher expression of cortactin in carcinoma cells than in adjacent normal laryngeal mucosa, no associations emerged between prognosis and the expression of cortactin or its isoforms in supraglottic LSCC. Statistical analysis found cortactin expression higher in less-differentiated LSCCs (p = 0.03). A significant direct correlation was found between cortactin and p-Y466-cortactin levels (p = 0.031), and between p-Y466-cortactin and p-Y421-cortactin levels (p = 0.001). Conclusions: Cortactin expression in carcinoma cells and its known involvement in the EGFR pathway suggest a role for this protein as a target for LSCC therapy. Further prospective studies are needed to investigate the potential of cortactin, p-Y466-cortactin and p-Y421-cortactin expression as markers of response to treatment (particularly EGFR-directed agents) in LSCC.
Comparison of 2 plating techniques for lateral clavicle fractures, using a new standardized biomechanical testing setup
Authors: Suter Cyrill , Majewski Martin , Nowakowski Andrej M. 
Published: September 2017

Background: Conservative treatment of lateral clavicle fractures (Neer type II) often ends with unsatisfactory results for patients. Operative treatment is thus gaining acceptance. A retrospective study found success using a double plate technique for these injuries. For the current study, a standardized testing setup was developed to compare the mechanical properties of single versus double plate technique for lateral clavicle fractures. Methods: Six synthetic bones were tested for each technique. Neer type IIB fractures were created using computer-aided design (CAD). Fatigue testing was carried out with a cantilever bending test. Parameters measured were cycles undergone, failure load and stiffness at the point of failure. Results: The standardized testing setup was able to provide reproducible failures. The double plate technique lasted about 16,000 more cycles and withstood an additional 22.4 N on average. Conclusions: The new modified standardized testing setup produced reproducible fixation failures for both clavicle fracture fixation techniques. The double plate technique seems to be mechanically superior to the single plate technique.
A randomized, single-blinded cross-over trial of ischemic preconditioning in Raynaud's phenomenon
Authors: Neferu Ramona , Vanderhoek Louise , Hewitt Sara , Nevskaya Tatiana , Pope Janet E. 
Published: September 2017

Introduction Ischemic preconditioning (IPC) is protective against future ischemia, with brief cycles of ischemia and reperfusion leading to the release of circulating endogenous compounds from ischemic cells. IPC may increase vasodilatory substances and improve Raynaud's phenomenon (RP). We hypothesized that IPC would be more effective than sham in RP treatment. Sample size required 18 participants to detect 5 fewer RP attacks per week. Methods This was a randomized single-blinded cross-over trial. The IPC intervention of inflating a standard blood pressure cuff on the upper arm (200 mmHg) and sham intervention (60 mmHg) were performed 3 times per week for 2 weeks, with a 2-week washout period between IPC and sham interventions. Cuff inflation was performed 4 times for 2.5 minutes, with 2.5 minutes between cuff inflation. Participants completed a daily diary on RP disease activity. Results Eighteen participants were enrolled (17 with secondary RP and 1 with primary RP); mean age 60.8 (SD 9.4) years, 89% female; and mean number of RP attacks/2 weeks in screen was 16.9 (SD 11.3). With IPC versus sham, results were not significant including an increase of 0.5 RP episodes/week (SD: 10.0; p = 0.84), decrease of 55.6 minutes per week (SD 516.4; p = 0.66), and a decrease in average severity of 0.4 points (on a scale of 0 to 10) (SD 12.9; p = 0.88). Secondary outcomes were also not significant. Conclusions No significant differences in RP disease activity were found between IPC and sham. This could be due to lack of effect of IPC on RP, too few treatments, or sham having a partial effect.
Ulnar artery vasculopathy: a common but nonspecific feature of systemic sclerosis
Authors: Kim Tae-Jong , Song Soon-Young , Ahn Hee Chang , Sung Yoon-Kyoung , Bae Sang-Cheol , Jun Jae-Bum 
Published: September 2017

Introduction Systemic sclerosis (SSc) is characterized by microvascular abnormalities and fibrosis. Several studies have reported that large vessel disease is also common in SSc. The aim of this case series was to investigate whether ulnar artery involvement in patients with SSc is a disease-specific phenomenon, as compared to other connective tissue diseases (CTD). Methods A total of 28 patients, including 7 with SSc and 12 with systemic lupus erythematosus (SLE), underwent brachial arteriography due to severe Raynaud's phenomenon and/or digital ulcerations and were enrolled in the study. They were divided into two groups: an SSc/SSc-overlap group and a non-SSc group. The collection of the clinical parameters was conducted to investigate the associations between clinical factors and the ulnar artery vasculopathy. Results The SSc/SSc-overlap group (n = 10) consisted of 7 patients with SSc and 3 with features overlapping SSc. In the non-SSc group (n = 18), 12 cases of SLE, 2 of mixed connective tissue disease, 1 of dermatomyositis + SLE, 1 of rheumatoid arthritis, 1 of Sjogren's syndrome, and 1 case of skin vasculitis, were included. The relative frequencies of ulnar artery involvement were not significantly different between the SSc/SSc-overlap and non-SSc groups, respectively (n = 6, 60% vs. n = 9, 50%, p = 0.611). Conclusions Although ulnar artery involvement was frequently detected in patients with SSc/SSc-overlap, it was also a common finding in other CTDs; therefore, it is not specific to SSc or SSc-overlap diseases.
Liberdades de expressão e de informação em face da igualdade e dignidade humana: o caso Siegfried Ellwanger | Freedoms of speech and of information facing the of human equality and dignity: The case of Siegfried Ellwanger |
Authors: Pompeu Gina Marcilio , Coelho Rosa Julia Plá 
Published: September 2017

Resumo: Este artigo versa sobre os aspectos mais relevantes da regulação do direito fundamental de expressão e de informação e de sua colisão com outros direitos, no plano jurídico internacional e brasileiro. O estudo compila julgados dos Tribunais Internacionais e outros órgãos responsáveis pelo monitoramento de tratados de Direitos Humanos, com o escopo de apontar formas de solução para os conflitos de bens hoje existentes. Igualmente, discute a previsão e o tratamento dado à tais direitos no ordenamento constitucional brasileiro. Finalmente, analisa um hard case julgado pelo Supremo Tribunal Federal - caso Siegfried Ellwanger -, no qual a colisão entre os direitos protegidos se evidenciou, apontando a solução para o choque entre o direito de livre expressão e a dignidade humana.
Palavras-chaves: Colisão de direitos fundamentais. Direitos humanos. Liberdade de expressão. Liberdade de informação. Igualdade. Dignidade humana.

Abstract: This article deals with the most relevant aspects of the fundamental right of speech and of information and its collision with other rights, in the international and Brazilian juridical spheres. The study carried out in its context compiles rulings of the international tribunals and other bodies responsible for the monitoring of human rights treaties, with the purpose of pointing out ways of solving the conflicts of goods that exist today. It also discusses the prediction and treatment of such rights in the Brazilian constitutional order. Finally, it analyzes a hard case judged by the Supreme Federal Court (STF) (Siegfried Ellwanger’s case), in which the collision between the rights protected was evident, pointing out the solution to the clash between the right of free expression and human dignity.
Keywords: Collision between fundamental rights. Equality. Freedom of expression. Freedom of information. Human dignity. Human Rights.
Negociação coletiva de trabalho como direito fundamental | Collective labor negotiation a fundamental right
Authors: Stürmer Gilberto 
Published: September 2017

Resumo: O presente artigo tem como objetivo analisar a negociação coletiva de trabalho como um direito fundamental. Este artigo parte da analise conceitual do conflitos coletivos de trabalho, seguido pelo estudo da negociação coletiva de trabalho como direito fundamental, com fundamento na Constituição da República Federativa do Brasil de 1988, nas convenções da Organização Internacional do Trabalho ratificadas pelo Brasil sobre a matéria e na legislação nacional sobre o tema, com a recentemente aprovada Lei nº 13.467, de 13 de julho de 2017 que, com a vacatio legis, entrará em vigor 120 dias após a sua publicação. Os novos artigos 611-A e 611-B da Consolidação das Leis do Trabalho propõem força de lei para a negociação coletiva de trabalho, afastando as hipóteses que fazem parte do rol dos direitos fundamentais sociais trabalhistas previstos no artigo 7º da Constituição Federal e que não podem ser objeto de negociação.
Palavras-chave: conflitos coletivos de trabalho. Negociação coletiva de trabalho. Direitos sociais. Direitos fundamentais. Reforma trabalhista.

Abstract: [This article aims to analyze collective bargaining as a fundamental right. This article is based on the conceptual analysis of collective labor conflicts, followed by the study of collective bargaining as a fundamental right, based on the Constitution of the Federative Republic of Brazil of 1988, the International Labor Organization conventions ratified by Brazil on the subject and In the national legislation on the subject, with the recently approved Law no. 13467 of July 13, 2017 which, with the vacatio legis, will come into force 120 days after its publication. The new Articles 611-A and 611-B of the Consolidation of Labor Laws propose a force of law for the collective bargaining of labor, removing the assumptions that form part of the list of fundamental social labor rights provided for in article 7 of the Federal Constitution and which do not Can be traded.
Keywords: Collective labour negotiation. Fundamental rights. Labor reform. Social rights.
Análise da estrutura produtiva e do consumo de papéis tissue no Brasil
Authors: Da Costa Lucas Ayres , Bacha Carlos José Caetano 
Published: September 2017

Este artigo analisa a estrutura produtiva do segmento produtor de papéis tissue no Brasil
(em especial, a sua concentração), destacando a evolução da produção e do consumo desses
papéis no país. Para tanto, consideram-se dados de 1962 a 2015, dando atenção especial
aos anos a partir de 1980. Partiu-se do paradigma estrutura-conduta-desempenho para
ressaltar que aspectos daquele segmento estão sendo analisados, a saber: a sua estrutura
de produção e as suas condições de demanda. A partir de dados coletados das associações
que representam o segmento em análise e do Euromonitor, indicadores de concentração da
produção (como o CR4, CR8 e HHI) foram calculados, bem como foram estimadas equações
de demanda. Entre as conclusões do artigo, ressaltam-se: (1) no período de 1962 a 2015, a
produção brasileira de papéis tissue cresceu à taxa geométrica anual de 7,48%, frente ao
crescimento de 5,71% a.a. da produção total de papéis. Consequentemente, a importância
dos papéis tissue na produção total de papéis no Brasil passou de 4,2%, em 1962, para
10,8% em 2015; (2) devido a suas características de grande volume e baixo peso, o comércio
exterior dos papéis tissue é pequeno, garantindo poder de mercado para as empresas aqui
instaladas na fixação de preços; (3) há concentração regional na produção de papéis tissue,
mas que tem reduzido ao longo do tempo; (4) a demanda desse produto é inelástica a preço
e elástica a renda. As elasticidades preço e renda estimadas para o período de 1980 a 2015
foram de -0,076 e 1,671, respectivamente, mostrando que apesar de ser um produto de
luxo, a demanda de papéis tissue é pouco sensível a variações de preços.
Palavras-chave: Demanda. Equações de demanda. Papéis tissue. Produção.
Um estudo sobre clientes indesejados em empresas de pequeno porte
Authors: Toda Favio Akiyoshi 
Published: September 2017

Clientes Indesejados fazem parte da rotina de muitas empresas e, infelizmente, afetam
não apenas os processos existentes das firmas, mas prejudicam também a motivação dos
funcionários e, por vezes, geram incômodos em outros clientes. Este estudo exploratório
investigou os tipos de clientes indesejados em negócios de pequeno porte, em academias
de ginástica, bares, pet shops e salões de beleza, junto aos funcionários de atendimento e
de venda que estavam na “linha de frente” com os clientes. A compreensão desta realidade
contribui para repensar algumas ações que venham a proporcionar maior satisfação dos
funcionários, buscando treiná-los para lidar com tais dificuldades.
Palavras-chave: Clientes indesejados. Demarketing. Pequenas Empresas.
Kinetic Profiling of the Hydrolytic Reaction of Benazepril: Metabolic Pathway Simulation
Authors: Hemdan A , Michael Adel M 
Published: September 2017

Abstract
A simple, specific, and rapid kinetic study of benazepril (BNZ) hydrolysis was developed and validated using HPLC. BNZ was degraded using 0.1 N sodium hydroxide at room temperature to produce benazeprilat, which is an active metabolite of BNZ and acts as an angiotensin-converting enzyme inhibitor. Analysis was carried out using an Athena C18 column (4.6 × 250 mm, 5 µm particle size). The mobile phase consists of a mixture of phosphate buffer (pH 4.5) and acetonitrile (53 + 47, v/v) at a flow rate of 1 mL/min. UV detection was accomplished at 242 nm using moexipril as the internal standard. The method was validated according to International Conference on Harmonization guidelines, and the calibration curve was linear over the range 10–100 µg/mL, with acceptable accuracy and precision. Kinetic profiling of the hydrolysis was shown to follow pseudo-first-order kinetics. The method was applied to the assay of BNZ in combined dosage form with no interference from other ingredients. The obtained results were statistically compared with those of the official method, showing no significant difference.
Estratégias de educação ambiental na educação infantil
Authors: Sousa Patrícia Patrício Miranda , Leite Julia Ingrette Tobias , Szulczewski Nívia Alves Sales , Carvalho Aluísio Vasconcelos 
Published: September 2017

É notório que a Educação ambiental contribui de forma relevante para mudança de hábitos e posturas das pessoas em relação ao meio ambiente. Assim, com as mudanças ocorridas no sistema educacional nas últimas décadas, percebe-se que a questão voltada para a Educação Ambiental tem ganhado cada vez mais espaço na escola. Desse modo, este artigo tem como objetivo analisar o processo de ensino e aprendizagem em Educação Ambiental na Educação Infantil. Para tanto, utilizou-se o levantamento bibliográfico como pesquisa, e, por ter um caráter qualitativo permitiu uma compreensão mais ampla do assunto em estudo. O texto mostra diversos questionamentos dos teóricos sobre a importância de se trabalhar esse tema ainda na Educação Infantil afim de que as crianças compreendam desde cedo a respeitar e cuidar do ambiente.
Low Evapotranspiration Enhances the Resilience of Peatland Carbon Stocks to Fire
Authors: Kettridge N. , Lukenbach M. C. , Hokanson K. J. , Hopkinson C. , Devito K. J. , Petrone R. M. , Mendoza C. A. , Waddington J. M. 
Published: September 2017

AbstractBoreal peatlands may be vulnerable to projected changes in the wildfire regime under future climates. Extreme drying during the sensitive postfire period may exceed peatland ecohydrological resilience, triggering long‐term degradation of these globally significant carbon stocks. Despite these concerns, we show low peatland evapotranspiration at both the plot‐ and landscape‐scale postfire, in water‐limited peatlands dominated by feather moss that are ubiquitous across continental western Canada. Low postfire evapotranspiration enhances the resilience of carbon stocks in such peatlands to wildfire disturbance and reinforces their function as a regional source of water. Near‐surface water repellency may provide an important, previously unexplored, regulator of peatland evapotranspiration that can induce low evapotranspiration in the initial postfire years by restricting the supply of water to the peat surface.
Unique alkyl ketene dimer Pickering‐based dispersions: Preparation and application to paper sizing
Authors: Zhao Qi , Liu Wenxia , Li Guodong , Lucia Lucian A. , Wang Huili , Yu Dehai 
Published: September 2017

ABSTRACTHerein, particle‐stabilized alkyl ketene dimer (AKD) dispersions were prepared using dodecyl trimethyl ammonium chloride (DTAC)‐modified laponite as the stabilizer, and sodium alginate (SA) as the protective colloid. The modification of laponite particles with DTAC, which was characterized by transmission electron microscopy, infrared spectroscopy, and X‐ray diffraction technique, moderately decreases the negative zeta potential and causes the dehydration of laponite particles. Consequently, the modification of laponite promotes the absorption of laponite particles on AKD droplets/spherical particle surfaces, leading to formation of AKD dispersions with reduced particle size and enhanced uniformity when DTAC‐to‐laponite mass ratio is <1%. Meanwhile, SA significantly increases the stability of the AKD dispersions and provides stable AKD dispersions with smaller particles when SA‐to‐AKD mass ratio is <0.08%. By means of confocal laser scanning microscopy, scanning electron microscope imaging and energy dispersive spectroscopy (EDS)/EDS mapping, the function of DTAC‐modified laponite particles in stabilization of AKD dispersions was found to include both formation of a particle barrier around AKD particles and an increase in the moving resistance of AKD particles by laponite particles with SA. AKD dispersions at a DTAC‐to‐laponite mass ratio 1.0% and SA‐to‐AKD mass ratio 0.054% provide the smallest droplet size and best sizing performance. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45730.
BetoScan 2.0 – Werkzeug für die proaktive Lebenszyklusbetrachtung
Authors: Moryson Ralf , Herrmann Hans‐Georg 
Published: September 2017

AbstractZunehmendes Verkehrsaufkommen, höhere Gesamtgewichte und klimatische Veränderungen haben in den letzten Jahrzehnten den Alterungsprozess der Infrastruktur verstärkt. Der daraus resultierende Anstieg der Erhaltungskosten erfordert einen optimierten Einsatz der Erhaltungsmittel der Betreiber. Basis des Erhaltungsmanagements ist ein umfassendes Wissen über den Zustand der Bauwerke. Die aktuellen Richtlinien (z. B. DIN 1076, RI‐EBW‐PRÜF) definieren Prüfintervalle, die üblicherweise mehrere Jahre umfassen; wobei viele Methoden der Zustandserfassung auf einer handnahen Prüfung beruhen. Ergebnisse der Zustandsbewertung werden in Kennzahlen zusammengefasst, die einen objektiven Vergleich gestatten. Die daraus ableitbare Priorisierung unterstützt die reaktive Substanzerhaltung bei der Optimierung der Ressourcen. Schädigungsprozesse können damit aber über große Zeiträume ihr destruktives Potenzial zur Entfaltung bringen. Besonders bei großen Bauwerken zieht dies einen höheren Aufwand für Prüfung und Instandhaltung nach sich. Automatisierte, multimodale Zustandserfassungssysteme, wie der hier vorgestellte BetoScan, unterstützen daher gleichermaßen Bauwerksprüfer wie Betreiber. Durch einen schnelleren Prüfprozess, höhere Reproduzierbarkeit der Ergebnisse sowie eine größere Informationsbasis unterstützt BetoScan eine optimale Diagnose und fördert damit Konzepte einer proaktiven Substanzerhaltung mit dem Ziel, Schädigungsprozesse frühzeitig zu erkennen und zu beseitigen.
Comparison between the Valsalva maneuver and intraoperative traction measurements in pelvic organ prolapse assessment
Authors: Doumouchtsis Stergios K. , Gauthaman Nivedita , Khunda Azar , Basu Maya , Dadhwal Kiran , Gayle Yasmin V. , Durnea Constantin M. 
Published: September 2017

AbstractObjectiveTo compare the assessment of pelvic organ prolapse (POP) between the Pelvic Organ Prolapse Quantification (POP‐Q) system with Valsalva maneuver and intraoperative measurement with mechanical traction.MethodsA prospective observational study included 100 women with POP attending a tertiary urogynecology clinic in the UK and undergoing vaginal prolapse surgical procedures between October 2011 and October 2014. The women were examined in the clinic using POP‐Q with the Valsalva maneuver and in the operating theater under general anesthesia with mechanical traction. The two sets of measurements were compared.ResultsAll POP‐Q measurements obtained with traction demonstrated significantly higher descent as compared with those measured by Valsalva maneuver (mean differences: Aa 0.64 cm; Ap 1.32 cm; Ba 0.96 cm; Bp 1.34 cm; C 3.57 cm; D 3.40 cm; all P<0.001). The perineal body and total vaginal lengths did not differ significantly.ConclusionMeasurements of six POP‐Q points obtained with traction showed a higher grade of POP than those assessed with Valsalva maneuver. On this basis, surgeons might decide on the extent of surgical procedure after examination under anesthesia; however, preoperative patient counselling would be essential to obtain consent for this approach. The clinical significance of the findings requires further evaluation.