bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poly (ADP-Ribose) Polymerase-1 (PARP-1) Induction by Cocaine Is Post-Transcriptionally Regulated by miR-125b
Authors: Dash Sabyasachi , Balasubramaniam Muthukumar , Rana Tanu , Godino Arthur , Peck Emily G. , Goodwin Jeffery Shawn , Villalta Fernando , Calipari Erin S. , Nestler Eric J. , Dash Chandravanu , Pandhare Jui 
Published: August 2017

AbstractCocaine exposure alters gene expression in the brain via methylation and acetylation of histones along with methylation of DNA. Recently, poly (ADP-ribose) polymerase-1 (PARP-1) catalyzed PARylation has been reported as an important regulator of cocaine-mediated gene expression. In this study, we report that the cellular microRNA “miR-125b” plays a key role for cocaine-induced PARP-1 expression. Acute and chronic cocaine exposure resulted in the downregulation of miR-125b concurrent with upregulation of PARP-1 in dopaminergic neuronal cells and nucleus accumbens (NAc) of mice but not in the medial prefrontal cortex (PFC) or ventral tegmental area (VTA).In silicoanalysis predicted a binding site of miR-125b in a conserved 3’-untranslated region (3’UTR) of the PARP-1 mRNA. Knockdown and overexpression studies showed that miR-125b levels negatively correlate with PARP-1 protein expression. Luciferase reporter assay using a vector containing the 3’UTR of PARP-1 mRNA confirmed regulation of PARP-1 by miR-125b. Specific nucleotide mutations within the binding site abrogated miR-125b’s regulatory effect on PARP-1 3’UTR. Finally, we established that downregulation of miR-125b and concurrent upregulation of PARP-1 is dependent on binding of cocaine to the dopamine transporter (DAT). Collectively, these results identify miR-125b as a post-transcriptional regulator of PARP-1 expression and establish a novel mechanism underlying the molecular effects of cocaine action.
Modulating NAD+ metabolism, from bench to bedside
Authors: Katsyuba Elena , Auwerx Johan 
Published: August 2017

AbstractDiscovered in the beginning of the 20th century, nicotinamide adenine dinucleotide (NAD+) has evolved from a simple oxidoreductase cofactor to being an essential cosubstrate for a wide range of regulatory proteins that include the sirtuin family of NAD+‐dependent protein deacylases, widely recognized regulators of metabolic function and longevity. Altered NAD+ metabolism is associated with aging and many pathological conditions, such as metabolic diseases and disorders of the muscular and neuronal systems. Conversely, increased NAD+ levels have shown to be beneficial in a broad spectrum of diseases. Here, we review the fundamental aspects of NAD+ biochemistry and metabolism and discuss how boosting NAD+ content can help ameliorate mitochondrial homeostasis and as such improve healthspan and lifespan.
Metabolic and endocrine connections of 17-hydroxypregnenolone in polycystic ovary syndrome women
Authors: de Medeiros Sebastião Freitas , Ormond Cinthia Marenza , de Medeiros Matheus Antônio Souto , de Souza Santos Nayara , Banhara Camila Regis , Yamamoto Márcia Marly Winck 
Published: August 2017

Objective
To examine the anthropometric, and metabolic connections of 17-hydroxypregnenolone in the normo- and hyperandrogenemic polycystic ovary syndrome phenotypes.

Materials and methods
This cohort study was conducted at the Julio Muller University Hospital, Cuiabá, Brazil, between January 2014 and July 2016, and 91 normal cycling healthy women, 46 normoandrogenemic and 147 hyperandrogenemic, patients with polycystic ovary syndrome (PCOS) were enrolled according to the Rotterdam criteria. Several anthropometric, biochemical and hormonal parameters were properly verified and correlated with 17-hydroxypregnenolone (17-OHPE) concentrations.

Results
17-OHPE was higher in hyperandrogenemic PCOS than in normoandrogenemic PCOS and in control groups (P = 0.032 and P < 0.001, respectively). In healthy controls, 17-OHPE was positively associated with glucose, free estrogen index, DHEAS and negatively associated with compounds S. In normoandrogenemic PCOS patients, 17-OHPE presented positive correlations with VAI, LAP, cortisol, insulin and HOMA-IR. In the hyperandrogenemic group, 17-OHPE presented significant negative correlations with most anthropometric parameters, HOMA-IR, HOMA %B, estradiol, free estrogen index (FEI), C-peptide, and TG levels and positive correlations with HOMA-S and high-density lipoprotein cholesterol (HDL-C), sex-hormone binding globulin (SHBG), androstenedione (A4) and dehydroepiandrosterone (DHEA). Regarding hyperandrogenemic PCOS, and using a stepwise multiple regression, only HOMA-S and WHR were retained in the model (R2 = 0.294, P < 0.001).

Conclusion
17-OHPE exhibited different relationships with anthropometric, and biochemical parameters in PCOS patients, depending on the androgen levels. In PCOS subjects with high androgen concentrations, 17-OHPE was negatively associated with most anthropometric parameters, particularly with those used as markers of adipose tissue dysfunction and frequently employed as predictors of cardiovascular disease risk; otherwise, 17-OHPE was positively associated with HDL-C and HOMA-S in this patients. Future studies are required to evaluate the clinical implications of these novel findings.
The use of ICT in SMES exporting
Authors: Escandón Barbosa Diana Marcela , Hurtado Ayala Andrea 
Published: August 2017

This article analyzes and compares the level of use of ICTs in enterprises with traditional internationalization and born global in Colombia. Through a survey conducted in 2014 on sample 400 Colombian enterprises, cluster analysis was performed to establish the influence of ICT use on business performance for each type of enterprise. It is evident that there is an increased use of ICT in the Born Global firms following the start of early internationalization leading to increased access to market information, while traditional exporters still have restrictions on the frequency and intensity in the use of ICT. En este artículo se analiza y compara el nivel de utilización de las TICs en las empresas con internacionalización tradicional y en las empresas born global en Colombia. A través de una encuesta realizada en el 2014 a una muestra de 400 empresas colombianas se realizó análisis clúster para establecer la influencia del uso de las TICs sobre el desempeño empresarial. Se evidencia que existe un mayor uso de las TICs en las empresas Born Global como consecuencia del inicio de internacionalización temprana que conduce a un mayor acceso a información del mercado, mientras que las exportadoras tradicionales aun presentan limitantes en la frecuencia e intensidad en el uso de las TICs.Neste artigo analisa e compara o nível de utilização das TIC nas empresas com a internacionalização tradicional e as empresas globais que nascem na Colômbia. Através de um inquérito em 2014 a uma amostra de 400 empresas colombianas, análise de cluster foi realizada para estabelecer a influência da utilização das TIC no desempenho dos negócios. É evidente que há um aumento da utilização das TIC nas empresas nascidas globais após o início da internacionalização precoce levando a um maior acesso à informação de mercado, enquanto os exportadores tradicionais ainda têm restrições sobre a frequência e intensidade no uso de TIC.
ICT as a strategy for the strengthening of textual understanding and interpretation/Las TIC: estrategia para el fortalecimiento de la comprensión e interpretación textual
Authors: Buelvas Cogollo Luis Alberto , Aguilar Tirado Heidy , Zabala Calonge Camilo , Roys Romero Nancy 
Published: August 2017

La comprensión e interpretación textual son dificultades que afectan a los estudiantes, por consiguiente en el grado sexto de la Institución Educativa Rural Antonio Nariño de San Pedro – Antioquia se implementó una estrategia pedagógica basada en las TIC que consistió en la aplicación de un pre-test permitiendo conocer el nivel de comprensión e interpretación textual, continuando con el proceso formativo apoyado en las TIC, finalizando con el pos-test que evidenció el avance del estudio realizado. La metodología utilizada es mixta, cuantitativa con técnicas de encuesta con una muestra de 38 estudiantes y datos cualitativos, que describen el proceso y los resultados. Al finalizar los resultados muestran que el 89.47% de los estudiantes mostraron cambios en la comprensión e interpretación textual.
The Grammar of Trust and Distrust under State Socialism after Stalin. Introduction
Authors: Tikhomirov Alexey 
Published: August 2017

The Grammar of Trust and Distrust under State Socialism after Stalin. Introduction The introduction to the special issue defines trust/distrust from an interdisciplinary perspective, treating these emotions as analytical categories and outlining their potential for historical analysis. Inspired by the emotional and sensory turns, the guest editor examines the shift from Stalinist violence towards a politics of trust and empathy. This new politics saw these feelings as powerful emotional forces and moral resources that not only made it possible to renegotiate a social contract between the state, society and the individual, but also enabled the stabilisation of the Eastern bloc as a whole in the post-Stalin era. Differentiating between regimes and communities of trust/distrust, the author sheds light on the grammar of trust and distrust under state socialism, which impacted the shared sense of stability and inner hybridity of the socialist personality. By connecting trust and distrust with the key analytical categories of gender and generation, morality and power, consumption and materiality, and self and subjectivity, this special issue is a contribution to a history of trust and distrust that provides further reflection on the unceasing debate about what socialism was and what the lived experience of socialism continues to be in post-communist space.
Taste of Trust: Documenting Solidarity in Soviet Private Cookbooks, 1950–1980s
Authors: Pirogovskaya Maria 
Published: August 2017

Taste of Trust: Documenting Solidarity in Soviet Private Cookbooks, 1950-1980s This paper investigates the problem of trust and solidarity as they were mirrored in private manuscripts on cooking and housekeeping, and traces the circulation of culinary information within specific social networks. Soviet handwritten cookbooks, though rooted in the nineteenth-century tradition, constituted a phenomenon in and of themselves. They maintained and transmitted everyday knowledge on cooking, which was perceived as being opposed to state-published cooking books and brochures. Gastronomical models represented by The Book of Tasty and Healthy Food and other culinary writings were beyond reach of an average Soviet citizen. On the one hand, this inaccessibility aroused huge scepticism; on the other hand, it invigorated «invisible cuisine» – an informal exchange of routine culinary skills that had aimed to accommodate official quasi-reality to the Soviet everyday life, and to reconcile a dream with a real food basket. Up until perestroika, private cookbooks functioned not only as a corpus of personal skills that could both compensate flaws of economics of shortage and control everyday life, but also an important tool of gender socialisation that could be used to support social prestige, create solidarity and reinforce social bonds.
Perestroika and the Loss of Certainties: The Post-Soviet Revaluation of Soviet Money Practices and Social Equality
Authors: Bönker Kirsten 
Published: August 2017

Perestroika and the Loss of Certainties: The Post-Soviet Revaluation of Soviet Money Practices and Social Equality Soviet propaganda painted a picture of an egalitarian, «humane» and «warm» socialist society, whereas the disdained stereotype of capitalism suggested social relations that were dominated by materialism, egoism and money. However, the perestroika reforms constituted a profound iconoclasm and brought about a harsh state of social disintegration for many people. In order to trace the contemporary perceptions of these changes, possible threats, crisis scenarios, as well as the opportunities that the perestroika entailed, this article explores the attitudes of former Soviet consumers towards money, and their consumer practices based on 42 oral history interviews. They strongly suggest that the late Soviet society was not characterised by disintegration. From a comparative perspective on Soviet and post-Soviet times, Soviet money practices offered reliability and predictability of living conditions in an environment with less consumer choice than today. Many people perceived the Soviet social, cultural and economic framework as having provided comparatively greater security in everyday life. The new privacy of the 1960s and the 1970s offered considerable sources for building people's trust in the regime as it became linked to notions of stability, security, and predictability. Therefore, we should consider these subjective dimensions of «normality» as providing grounds for current nostalgia about the alleged socio-economic stability and political security up until perestroika.
Kolumbus transnational: Verflochtene Geschichtskulturen und europäische Medienlandschaften im Kontext des 400. Jubiläums der Entdeckung Amerikas 1892
Authors: Frysztacka Clara , Herborn Klaus , Palli Martina , Scheidt Tobias 
Published: August 2017

Columbus in Transnational Perspective: Entangled Historical Cultures and European Media Landscapes in the Context of the 400th Anniversary of the Discovery of America (1892) While in historical research there is a general call for transnational history, the transnational level of historical cultures often remains under-represented. The latter has for long focused on the development of single national narratives when dealing with historical cultures. This is especially true for late nineteenth-century Europe, when the continent can be seen at the height of national divide and imperial ambition. Consequently, its historiographies are perceived to play a major role in the construction of separate national identities. By contrast, this article utilises the celebrations around the quartercentenary of Christopher Columbus's arrival in the Americas as a case study to analyse how forms of approaching, interpreting and transmitting history in different European contexts were deeply entangled. The study is based on illustrated newspapers and popular periodicals from five European regions, which provided access to textual and visual material for mass audiences to an unprecedented extent. The analysis of articles covering the anniversary unveils regional, national, transnational and pan-European patterns of historical sense-making. These affect historical narratives as well as the ways in which the press illustrated the past, produced historical truth, and created identification with the historical personage. Columbus and his deeds became symbols of modernism and embodiments of European superiority that were open for adaptation into different contexts. Therefore, historical cultures in Europe have to be characterised as both permeable and multi-dimensionally entangled.
A grafia das línguas gerais (Tupi) no século XVIII
Authors: Cruz Aline da 
Published: August 2017

Em 1863, o naturalista Karl Friedrich von Martius (1794 – 1868) publicou os Glossaria Linguarum Brasiliensium, uma coleção de vocabulários e listas de palavras sobre língua indígenas brasileiras. Nesse material, incluiu dois documentos que registravam línguas gerais (fam. Tupi-Guarani) do século XVIII: o Diccionario da Lingua Geral Brasílica, que registra a língua falada na Amazônia e o Diccionario de Verbos do Tupi Austral, que registra a língua que teria sido falada em São Paulo. Para von Martius, a língua geral amazônica era superior àquela falada em São Paulo, Cuiabá e Rio Grande do Sul. A partir da análise comparativa dos critérios de notação utilizados nos dois materiais, esta pesquisa procurou mostrar que as oscilações de representação das unidades lingüísticas no Diccionario de Verbos podem ter levado von Martius a manifestar opiniões depreciativas sobre o Tupi Austral em relação à Língua Geral Brasílica.
Um exame do(s) sufixo(s) -rã do Kaxinawá (Pano) registrado por Capistrano de Abreu
Authors: Christino Beatriz 
Published: August 2017

O presente artigo examina a natureza do(s) sufixo(s) –rã do Kaxinawá (Pano) registrado por Capistrano de Abreu (1853-1927) no início do século XX. Aborda-se a proposta de análise daquele pesquisador, assim como se empreende uma nova investigação das formas de ocorrência de –rã em contextos verbais e nominais em narrativas por ele recolhidas.
Duarte, Fábio Bonfim (2007). Estudos de morfossintaxe tenetehára.
Authors: Gonçalves Solange Aparecida 
Published: August 2017

O livro objetivo desta resenha tem sua origem na tese de doutorado em lingüísticadefendida na Faculdade de Letras da Universidade Federal de Minas Gerais pelo professor e lingüista Fábio Bonfim Duarte (2003). O presente livro trata da língua tenetehára. O autor chama atenção para os poucos estudos morfossintáticos existentes sobre a língua; nesse sentido, o objetivo principal do autor é, então, contribuir com a documentação da língua tenetehára.
The Management of Osteoporosis After Fragility Fracture
Authors: Morris Jonathan , Karkenny Alexa J. , Toro Jose B. 
Published: August 2017

➢ The greatest risk factor for fragility fracture is a previous fragility fracture.➢ During post-fracture follow-up, the orthopaedic surgeon has an opportunity to intervene in the management of osteoporosis.➢ A novel algorithm for interpreting laboratory values and starting antiresorptive and bone-stimulating agents is presented.
Upper-Extremity Extravasation
Authors: Gil Joseph A. , Shah Kalpit N. , Suarez Luis , Weiss Arnold-Peter C. 
Published: August 2017

➢ Delayed diagnosis and improper management of upper-extremity extravasation events result in long-term sequelae and are the basis of many medical litigation cases in the United States.➢ The extent of the injury resulting from an extravasation event depends on the toxicity of the agent, the volume extravasated, and the time to identify the event and to initiate intervention.➢ Timely intervention can prevent long-term sequelae such as contractures, complex regional pain syndrome, and neuromuscular deficits.
Coupled Fracture-Propagation and Semianalytical Models To Optimize Shale Gas Production
Authors: Yu Wei , Hu Xiaohu , Wu Kan , Sepehrnoori Kamy , Olson Jon E. 
Published: August 2017

Summary
With the development of shale gas reservoirs, various fracture-propagation models have been developed to predict hydraulic-fracture geometry by considering the stress-shadow effects. Also, many researchers have been working on the development of various production/simulation approaches to simulate production from the complex fracture geometries. The objective of this study is to combine the fracture-propagation modeling and reservoir simulation to optimize production in shale gas reservoirs. First, we have developed a semianalytical model to simulate shale gas production from the nonplanar-fracture geometry with varying fracture width and fracture permeability along fracture length. The important gas-transport mechanisms such as gas slippage, gas diffusion, and gas desorption are considered. Second, we have developed a fracture-propagation model to predict the nonplanar-fracture geometry by fully coupling elastic deformation of the rock and fluid flow. In this study, the effect of varying number of perforation clusters within a given stage ranging from two to six on the fracture propagation was investigated. Three values of stage spacing were considered including 100, 200, and 300 ft. After predicting the nonplanar-fracture geometry, the semianalytical model is used to simulate production from such fracture geometries. The effects of the number of clusters per stage for varying stage spacing on well productivity were examined. In addition, we compared the well performance with varying stage spacings of 100, 200, and 300 ft under a given lateral length of 2,500 ft. Furthermore, we coupled the fracture-propagation and semianalytical models to analyze a field well performance in a shale gas reservoir. Through the field-case study, a nonplanar-fracture geometry with a good history match was quantified. Also, the difference between the nonplanar-fracture geometry and the converted equivalent planar-fracture geometry with equal fracture length was examined. Finally, the optimal fracture-treatment design for the field well development was recommended. This work can provide new insights into optimization of the number of perforation clusters per stage within a given fracture stage in shale gas reservoirs.
Pengaruh Entertainment, Irritating dan Informativeness Iklan di Website di Kalangan Mahasiswa
Authors: Supriyadi Edy , Putriana Lies 
Published: August 2017

There are several advantages and disadvantages and advertising via the Internet. The appeal of advertising may also arise from given information element, the element of comfort but also sometimes lead to disturbing or irritation elements. The limited number of Internet users in Indonesia and the different backgrounds of individual Internet users in Indonesia certainly provide a different assessment of the advertisements contained on the Internet. There are 3 factors which was the starting point to explain how consumers interpret the value of advertising, namely: informativeness, entertainment and irritation. This research aims to discover whether there is a relationship between entertainment, informativeness, and irritation toward advertising values and whether there is a relationship between entertainment and advertising values toward attitude towards web advertising using statistics tools of path analysis and multiple regression. The research shows that there is a significant relationship between independent variables such as informativeness, entertainment and irritation simultaneously toward the advertising value but there are no significant relationship between entertainment and informativeness toward the advertising value individually. In the other model there is a significant relationship between informativeness, irritation and advertising values with the attitude towards web advertising.
A Study of Accountant Required Skills to Have Efficient Participation in the Implementation of XBRL
Authors: Asadizeidabadi Heshmatolah 
Published: August 2017

The role of the accountants in a business environment has been evolving over the years. Accountants need to have the implementation and maintenance skills of XBRL (extensible business reporting language) which is revolutionizing business reporting around the world, in the organization. The present study encompasses two aspects. First, it addresses the role of the accountant during the implementation and maintenance phase. Second, it finds the characteristics and skills of accountants that can help them in a successful implementation and maintenance of XBRL. In order to collect the data a questionnaire has been used. To analyze data two statistical methods, Regression and Pearson correlation have been used. The results of the study confirm that there is a significant relationship between the participation of accountants and successful implementation of XBRL.