bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prorenin/renin receptor blockade promotes a healthy fat distribution in obese mice
Authors: Tan Paul , Blais Carolane , Nguyen Thi M.‐D. , Schiller Peter W. , Gutkowska Jolanta , Lavoie Julie L. 
Published: July 2016

ObjectiveAdministration of the handle region peptide (HRP), a (pro)renin receptor blocker, decreases body weight gain and visceral adipose tissue (VAT) in high‐fat/high‐carbohydrate (HF/HC) diet‐fed mice. The objective of this study was to elucidate potential mechanisms implicated in these observations.MethodsMice were given a normal or a HF/HC diet along with saline or HRP for 10 weeks.ResultsIn HF/HC‐fed mice, HRP increased the expression of several enzymes implicated in lipogenesis and lipolysis in subcutaneous fat (SCF) while the expression of the enzyme implicated in the last step of lipogenesis decreased in VAT. A reduction was also observed in circulating free fatty acids in these animals which was accompanied by normalized adipocyte size in VAT and increased adipocyte size in SCF. ''Beiging'' is the evolution of a white adipose tissue toward a brown‐like phenotype characterized by an increased mitochondrial density and small lipid droplets. HRP increased the expression of' “beiging” markers in SCF of HF/HC diet‐fed mice.ConclusionsHRP treatment may favor healthy fat storage in SCF by activating a triglyceride/free fatty acid cycling and “beiging,” which could explain the body weight and fat mass reduction.
Upper airway viruses and bacteria and clinical outcomes in children with cough
Authors: O'Grady Kerry‐Ann F. , Grimwood Keith , Sloots Theo P. , Whiley David M. , Acworth Jason P. , Phillips Natalie , Marchant Julie , Goyal Vikas , Chang Anne B. 
Published: July 2016

SummaryBackground: Cough is symptomatic of a broad range of acute and chronic pediatric respiratory illnesses. No studies in children have tested for an extended panel of upper airway respiratory viruses and bacteria to identify whether they predict cough outcomes, irrespective of clinical diagnosis at the time of acute respiratory illness (ARI). We therefore determined whether upper airway microbes independently predicted hospitalization and persistent cough 28‐days later in children presenting with an ARI, including cough as a symptom. Methods: A cohort study of children aged <15‐years were followed for 28‐days after presenting to a pediatric emergency department with an ARI where cough was also a symptom. Socio‐demographic factors, presenting clinical features and a bilateral anterior nasal swab were collected at enrolment. Polymerase chain reaction assays tested for seven respiratory bacteria and 17 viruses. Predictors of hospitalization and persistent cough at day‐28 were evaluated in logistic regression models. Results: Eight hundred and seventeen children were included in the analysis; median age 27.7‐months. 116 (14.2%, 95%CI 11.8, 16.6) children were hospitalized and 163 (20.0%, 95%CI 17.2, 22.7) had persistent cough at day‐28. Hospitalized children were more likely to have RSV A or B detected on nasal swab than those not admitted (adjusted relative risk (aRR) 1.8, 95%CI 1.0, 3.3). M. catarrhalis was the only microbial difference between children with and without cough persistence (aRR for those with cough at day 28: 2.1, 95%CI 1.3, 3.1). Discussion: An etiologic role for M. catarrhalis in the pathogenesis of persistent cough post‐ARI is worth exploring, especially given the burden of chronic cough in children and its relationship with chronic lung disease. Pediatr Pulmonol. 2017;52:373–381. © 2016 Wiley Periodicals, Inc.
Bufalin induces apoptosis in vitro and has Antitumor activity against human lung cancer xenografts in vivo
Authors: Wu Shin‐Hwar , Bau Da‐Tian , Hsiao Yung‐Ting , Lu Kung‐Wen , Hsia Te‐Chun , Lien Jin‐Cherng , Ko Yang‐Ching , Hsu Wu‐Huei , Yang Su‐Tso , Huang Yi‐Ping , Chung Jing‐Gung 
Published: July 2016

ABSTRACTBufalin has been shown to be effective against a variety of cancer cells, but its role in lung cancer has never been studied in an animal model. In this study, we evaluated bufalin effects in a human lung cancer cell line NCI‐H460 both in vitro and in vivo. Bufalin caused significant cytotoxicity in NCI‐H460 cells at a concentration as low as 1 μM. DNA condensation was observed in bufalin‐treated cells in a dose‐dependent manner. Mitochondrial membrane potential (ΔΨm) was reduced and reactive oxygen species (ROS) were increased in bufalin‐treated NCI‐H460 cells. Levels of several proapoptotic proteins such as Fas, Fas‐ligand, cytochrome c, apoptosis protease activating factor‐1, endonuclease G, caspase‐3 and caspase‐9 were increased after bufalin treatment. At the same time, anti‐apoptotic B‐cell lymphoma 2 protein levels were reduced. Bufalin decreased glucose regulated protein‐78 gene expression but increased growth arrest‐ and DNA damage‐inducible 153 gene expression. Bufalin injected intraperitoneally in a dose‐dependent manner reduced tumor size in BALB/C nu/nu mice implanted with NCI‐H460 cells. Bufalin injection did not produce significant drug‐related toxicity in experimental animals except at a high dose (0.4 mg kg−1). In conclusion, low concentrations of bufalin can induce apoptosis in the human lung cancer cell line NCI‐H460 in vitro. Bufalin also reduced tumor size in mice injected with NCI‐H460 cells without significant drug‐related toxicity. These results indicate that bufalin may have potential to be developed as an agent for treating human non‐small cell lung cancer. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1305–1317, 2017.
National Trends in the Surgical Treatment of Non‐advanced Medullary Thyroid Cancer (MTC): An Evaluation of Adherence with the 2009 American Thyroid Association Guidelines
Authors: Chang Eun Hae Estelle , Lutfi Waseem , Feinglass Joseph , Reiher Alexandra Eudokia , Moo‐Young Tricia , Bhayani Mihir Kiran 
Published: July 2016

AbstractBackgroundMedullary thyroid cancer (MTC) represents the third most common type of thyroid cancer, and the prognosis depends on the stage of the disease at diagnosis and completeness of tumor resection. In 2009, the American Thyroid Association (ATA) published guidelines with evidence‐based recommendations for the treatment of MTC. This study aimed to determine national adherence rates of the treatment according to the ATA guidelines specific for MTC.MethodsPatients diagnosed with MTC from 2004 to 2013 were identified from the National Cancer Database. Guideline adherence rates for the treatment of MTC before and after the publication of ATA guidelines were analyzed and compared to determine patient and clinical variables that affected treatment.ResultsA total of 3693 patients diagnosed with MTC were identified. We found 60.3 % of the patients had localized MTC and 39.7 % had regional metastases. Older age, female sex and having Medicaid or being uninsured were directly correlated with more advanced disease upon diagnosis (p < 0.001). Overall, a greater proportion of patients received care in accordance with the recommendations following the ATA guidelines’ publication in 2009: 61.4 % of patients treated between 2004 and 2008 versus 66.8 % of patients treated between 2009 and 2013 received care in accordance with the recommendations (p < 0.01). Factors such as older age, African American race, localized disease at diagnosis, lower estimated median zip code household income and being treated in a community versus an academic hospital were associated with a lower likelihood of receiving care in accordance with the guidelines.ConclusionAdherence rates to the ATA recommendations for the treatment of MTC increased modestly following the publication of guidelines in 2009 with the largest increase seen in community hospitals. Being older, African American, diagnosed with localized disease and treated in a community hospital rather than in an academic institution was correlated with a lower likelihood of receiving treatment in accordance with the guidelines. Efforts should be made to continuously increase the adherence rates to the MTC ATA guidelines and to decrease socioeconomic disparities that continue to exist in the treatment of MTC.
Time series analysis of financial stability of banks: Evidence from Saudi Arabia
Authors: Ghassan Hassan B. , Fachin Stefano 
Published: July 2016

AbstractIslamic banks are characterized by their compliance to Islamic laws and practices, primarily the prohibition of interest and the trading of loans. During the 2008–2009 financial crisis, when a large number of conventional banks announced bankruptcy, no Islamic bank failures were reported. However, there is no clear consensus in the literature on the question of whether Islamic banks are more or less stable than conventional banks. To shed some light on this issue, we studied a sample of Saudi banks using quarterly data over a period centered on the 2008 financial crisis. Careful analysis of the data suggested first of all that many of the variables typically used in financial stability studies may be non‐stationary, a methodological point largely ignored in the literature. Using time series methods suitable for this type of data, we concluded that individual heterogeneity may matter more than either the conventional or Islamic nature of the banks. Concentrating on the largest banks, we find the Islamic banks contribute positively to the stability of the system.
Radiocarbon Chronology of the Mesolithic, Neolithic, Aeneolithic, and Bronze Age Sites in the Trans-Urals (Russia): A General Framework
Authors: Chairkina Natalia M , Kuzmin Yaroslav V , Hodgins Gregory W L 
Published: July 2016

AbstractThe chronology of the Mesolithic, Neolithic, Aeneolithic, and Bronze Age sites in the Trans-Urals (Russia) was studied, and a framework for previously established cultural complexes is suggested based on 153 radiocarbon dates. In this new chronological model, the Mesolithic is dated to ~10,000–6500 cal BC; the Neolithic complexes exist at ~6500–3800 cal BC; the Aeneolithic is dated to ~4300–2800 cal BC; the Early Bronze Age spans ~2500–2100 cal BC; and the Late Bronze Age can be preliminary assigned to ~1600–1100 cal BC.
New records of giant campanilid gastropods (Mollusca) from the southern North Sea Basin: implications for Eocene and Quaternary palaeogeography
Authors: Wesselingh F.P. , Janse A.C. , Vervoenen M. , van Nieulande F.A.D. 
Published: July 2016

AbstractThree specimens of the large-sized Eocene campanilid gastropod genus Campanile have been dredged from the modern sea floor in the Bruine Bank area (North Sea, Dutch sector). The material is identified here as Campanile parisiense rarinodosum, a subspecies hitherto unknown from the North Sea Basin. All three shells are strongly abraded, reflecting their secondary derivation. The new finds suggest that fossiliferous strata of probably late Lutetian (middle Eocene) age are represented in the southern North Sea Basin, situated most likely in the southeastern part of the UK sector. The present material of Campanile must have been reworked into the Dutch sector via Quaternary rivers. The occurrence of Campanile parisiense rarinodosum would indicate close biogeographic ties between the North Sea and the western French Atlantic basins during the late Lutetian. These new records thus shed light on the palaeogeography of the area during two widely separated geological time slices.
A brachiopod-dominated sea-floor assemblage from the Late Pliocene of the eastern Netherlands
Authors: Wesselingh F.P. , Peters W.J.M. , Munsterman D.K. 
Published: July 2016

AbstractA sea-floor assemblage from hardened sandstone boulders in which lingulid brachiopods predominate is recorded from the Oosterhout Formation near Balgoy (province of Gelderland, the Netherlands). Dinoflagellate cysts indicate a late Early-Late Pliocene (late Zanclean-Piacenzian) age of these boulders; the entire assemblage is indicative of clear marine waters near storm wave base along the southeastern margin of the North Sea Basin at the time. A possible commensal relationship between the lingulid brachiopods and the gastropod Calyptraea chinensis is implied.
The Geology of the Wicken Vision Area, lower Cam valley, Cambridgeshire, UK
Authors: Boreham S. 
Published: July 2016

AbstractThe geology of the Wicken Vision Area in the lower Cam valley is described with reference to a stacked series of ten cross-sections through Holocene and Pleistocene deposits, and Cretaceous/Jurassic bedrock across the region. A detailed cross-section through a Holocene palaeochannel, with radiocarbon dating and pollen analyses is also presented. The structural geology of the bedrock and the stratigraphic arrangement of the Pleistocene and Holocene deposits are used to describe landscape development for the area. This study offers a new understanding of the stratigraphy and context of the Holocene, Weichselian and earlier Pleistocene deposits of the lower Cam valley, and provides a unique view of sediment architecture in valley-fill sediments at the fen edge.
The discovery of the Fat Sand Play (Solling Formation, Triassic), Northern Dutch offshore – a case of serendipity
Authors: Jager J. de 
Published: July 2016

AbstractIn 1992, the well L9-7, drilled by the Nederlandse Aardolie Maatschappij (NAM) unexpectedly found a thick previously unknown sandstone interval with excellent reservoir characteristics in the Middle Buntsandstein (Triassic) of the Dutch Northern Offshore: the ‘Fat Sand’. A follow-up well, L9-8, found this reservoir gas-bearing in an accumulation that turned out have recoverable reserves of circa 1 Tcf of gas distributed over several fault compartments. This serendipitous discovery led to a frantic period in NAM's office trying to understand the setting of this local sand development and, most importantly, assess follow-up potential; could this sand be present elsewhere in a trapping configuration? The local depocentre in which the Fat Sand accumulated is considered to be caused by local extension along a strongly listric fault soling out on the top of the Zechstein Salt. This supra-salt fault seems to be caused by early east-west extension in the Dutch northern offshore. The shape of the fault plane was strongly influenced by the presence of the nearby Zechstein Salt, and by early salt flow, which was also triggered by E-W extension.
Unraveling the shallow geology of the western Wadden Sea using high resolution seismics
Authors: Paap B.F. , Dubelaar C.W. , Gunnink J.L. , Oost A.P. 
Published: July 2016

AbstractModelling of the shallow subsurface of the Dutch Wadden Sea is merely based on lithological information extracted from a limited amount of core samples. In order to improve the subsurface model and to provide a better basis for engineering purposes, seismic data have recently been acquired, processed and interpreted. This study focuses on the interpretation of seismic data in a pilot area in the southwestern part of the Dutch Wadden Sea near the Afsluitdijk. In order to acquire a maximum detail of subsurface information in a time-efficient way, multiple types of seismic systems were deployed simultaneously in a ‘one-sweep-survey’, providing information over depth ranges up to 60 m subsurface depth. Data from three seismic systems are presented; a chirp system, a boomer and sparker source in combination with hydrophone streamers. Geological interpretation of the seismic data was made by identifying seismic facies units and subsequently correlating them to geological cross-sections, running parallel to the Afsluitdijk. Geological cross-sections were derived from the existing geological and hydrogeological model and from relatively densely spaced borehole information. Six key reflectors were identified on the seismic data along the Dutch Afsluitdijk that make up four seismic facies units. Results of seismic profiles show good recognition of internal structures in especially Holocene sediments. A clay plug and a shallowing of a channel at the eastern side of the pilot area were interpreted as channel infills resulting from the rather sudden dominance by newer tidal channels to the west, probably coinciding with the opening of the Marsdiep channel. The channel wall deposits observed were interpreted as a turning of the drainage channel after closure of the IJsselmeer. Strong reflections of deeper levels (>15 m below Dutch vertical datum, i.e. N.A.P.) were interpreted as clay/sand interfaces in the Middle-Pleistocene Urk Formation and were more continuous than previously thought. It is concluded that high resolution seismics add valuable information yielding improved understanding of the sedimentary structure of the shallow subsurface, which in turn can be useful for near future engineering works along the Afsluitdijk.
The timing of aeolian events near archaeological settlements around Heidebos (Moervaart area, N Belgium)
Authors: Derese C. , Vandenberghe D.A.G. , Zwertvaegher A. , Court-Picon M. , Crombé P. , Verniers J. , Van den haute P. 
Published: July 2016

AbstractAt the locality of Heidebos (Moervaart area, N Flanders, Belgium), a sedimentary core was taken in the Maldegem-Stekene coversand ridge and dated using optically stimulated luminescence (OSL). The study aimed at contributing to an improved understanding of the evolution of the physical landscape around archaeological settlements in this area. The core comprised a 7 m thick series of laminated and massive aeolian sands, in which several organic layers were intercalated. From this sequence, 11 samples were collected for quartz-based SAR-OSL dating; an internally consistent dataset was obtained. The ages of the lowermost 1 m of the sedimentary sequence (15.5±1.1 ka and 17.3±1.3 ka) imply that these sediments may represent the time-equivalent deposit of a deflation phase that occurred during the Late Pleniglacial and led to the formation of a widespread desert pavement, regionally known as the Beuningen Gravel Bed. However, a significant part of the sediments (at least 4 m) was deposited later, i.e. during the Allerød and/or the Late Dryas. As such, the results allow establishing the genesis of the coversand ridge at the Heidebos locality on the basis of direct age information. The relatively high sedimentation rate and the absence of extensive soil formation in the record reflect periods of pronounced aeolian activity and landscape instability during the Late Glacial, which provides part of the environmental framework for human occupation in the area.
Settlement and land use on crevasse splay deposits; geoarchaeological research in the Rhine-Meuse Delta, the Netherlands
Authors: van Dinter M. , van Zijverden W.K. 
Published: July 2016

AbstractUntil recently, most archaeologists assumed that human occupation of the Dutch river area in the Neolithic period and Bronze Age was rare and predominantly seasonal. Settlement and land use were thought to be limited to abandoned alluvial ridges and aeolian dunes. However, recent archaeological research revealed that Neolithic and Bronze Age human activity occurred at many locations in the Rhine-Meuse Delta. Human settlement and agricultural land use in the Rhine-Meuse delta from at least 3200 BC to 1100 AD was much more common than previously thought. Crevasse splay complexes of active and abandoned river systems proved to have provided favourable sites for settlements. These elevated areas were suitable for agriculture, as they were fertile, easy to plough and possessed suitable hydrological conditions. In addition, people could exploit the surrounding floodplain for hunting, fishing or herding their cattle. Furthermore, the river or residual river channel was near for transport. From the start of the Middle Bronze Age B (1400 BC) occupation of crevasse splay deposits in the delta was widespread. Farmsteads were built on splays that varied in size and morphology. Some locations were abandoned after a few decades, while others remained occupied during a much longer period. During the period of occupation, the crevasse splays gradually lost their relatively high position in the landscape due to subsidence and ongoing sedimentation on the floodplain.LIDAR data combined with digital coring databases and/or detailed soil maps have proven to be an excellent method to identify and map crevasse splays and archaeological sites on these. The resulting new maps form a major basis for archaeological prospection and preservation policy.
Bite marks on early Holocene Tursiops truncatus fossils from the North Sea indicate scavenging by rays (Chondrichthyes, Rajidae)
Authors: van Netten H.H. , Reumer J.W.F. 
Published: July 2016

AbstractA number of Tursiops truncatus mandibles in the collection of fossil marine mammals in the Rotterdam Natural History Museum have marks consisting of several parallel linear grooves. These marks are also found on four atlas complexes, a scapula and on one vertebra. The hypothesis that they are bite marks and were caused by scavenging rays (Rajidae, Chondrichthyes) was tested with a real-life experiment using different shark and ray species, allowing them to scavenge on cow ribs as proxies for the dolphin bones. The bite marks of these animals were compared with the fossil marks and show that the fossil marks are most likely caused by scavenging rays.
Notes on some trace fossils and other parataxa from the Maastrichtian type area, southeast Netherlands and northeast Belgium
Authors: Donovan S.K. , Jagt J.W.M. , Lewis D.N. 
Published: July 2016

AbstractNew specimens described herein add to our knowledge of uncommon parataxa (embedment structures, borings and a certain type of burrow) from the type area of the Maastrichtian Stage, the material originating from the ENCI-HeidelbergCement Group (Maastricht), Ankerpoort-'t Rooth (Bemelen) and former Blom (Berg en Terblijt) quarries in southern Limburg (the Netherlands), and from the CBR-Romontbos (Eben Emael) and CPL SA (Haccourt) chalk pits in the province of Liège (northeast Belgium). AlthoughCentrichnus eccentricusBromley & Martinell has previously been recorded from this area, it has not received formal description; the specimen documented herein shares a test of the echinoidEchinocorysgr.conoideawith numerous other episkeletozoans.Podichnuscf.centrifugalisBromley & Surlyk occurs both on echinocorythid echinoid tests and guards of belemnitellid coleoids; two out of seven specimens display radial discontinuous channels, indicative of the extreme penetration of filaments from the attached brachiopod's pedicle.Renichnus arcuatusMayoral shows a range of morphologies, from the embedment structure sensu stricto through to specimens retaining internal moulds of the producing, embedded vermetid gastropod to free shells ofVermetus binkhorstiCossmann. Burrows packed with bioclastic debris, particularly primary spines and a few test plates of phymosomatid echinoids, present a systematic conundrum, although appearing comparable to the ichnogeneraNummiperaHölder andBaronichnusBreton in several respects.
The belemnite zonation of the uppermost Cretaceous in the Maastricht-Aachen-Liège, Brabant-Méhaigne and Mons areas (Belgium, southeast Netherlands)
Authors: Keutgen N. 
Published: July 2016

AbstractAn overview is presented of belemnitellid faunas of Santonian to Maastrichtian (Late Cretaceous) age in the Mons Basin and in the Brabant-Méhaigne and Maastricht-Aachen-Liège areas (Belgium, southeast Netherlands). As many as twenty-two species of the generaActinocamaxMiller, 1823,GonioteuthisBayle, 1878,Belemnitellad'Orbigny, 1840 andBelemnellaNowak, 1913 have been recorded to date. On the basis of these, thirteen zones can be distinguished: three in the Santonian (G. w. westfalica, G. westfalicagranulata and G. granulata), six in the Campanian (G. granulataquadrata, G. quadrata, Blt. mucronata, Blt. woodi, Blt. minorI andBlt. minorII) and four in the Maastrichtian (Bln. obtusa, Bln. ex gr. sumensis/cimbrica, Blt. juniorandBln. kazimiroviensis). Correlative schemes between these zones and those proposed for Norfolk (southeast England) and for the combined Lägerdorf-Kronsmoor-Hemmoor section (northern Germany) are presented. The belemnitellid assemblage of the study area closely resembles that of Norfolk, but differs from the late Campanian faunas of northwest Germany.