bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posttraumatic Cavernous Segment Internal Carotid Artery Aneurysmal Rupture Presenting as Tentorial Subdural Hematoma
Authors: Emmanuel Thas , Duvuru Shyam , Shunmugam Syamala 
Published: December 2016

AbstractTraumatic aneurysm rupture following a closed head injury is rare. The rupture of a cavernous internal carotid artery (ICA) aneurysm following a head injury presenting as a tentorial subdural hematoma has not been reported in the literature. We discuss a 50-year-old woman with a closed head injury with her initial computed tomography scan showing a tentorial subdural hematoma. Further investigations revealed the presence of a ruptured cavernous ICA aneurysm. We also conducted a literature review of posttraumatic ICA aneurysmal rupture.
Restriction of Postoperative Joint Loading in a Murine Model of Anterior Cruciate Ligament Reconstruction: Botulinum Toxin Paralysis and External Fixation
Authors: Lebaschi Amir , Deng Xiang-Hua , Coleman Nathan , Camp Christopher , Zong Jianchun , Carbone Andrew , Carballo Camila , Cong Guang-Ting , Album Zoe , Rodeo Scott 
Published: December 2016

AbstractControl of knee motion in small animal models is necessary to study the effect of mechanical load on the healing process. This can be especially challenging in mice, which are being increasingly used for various orthopedic reconstruction models. We explored the feasibility of botulinum toxin (Botox; Allergan, Dublin, Ireland) paralysis and a newly designed external fixator to restrict motion of the knee in mice undergoing anterior cruciate ligament (ACL) reconstruction. Nineteen C57BL/6 mice were allocated to two groups: (1) Botox group (n = 9) and (2) external fixator group (n = 10). Mice in Botox group received two different doses of Botox: 0.25 unit (n = 3) and 0.5 unit (n = 6). Injection was performed 72 hours prior to ACL reconstruction into the quadriceps, hamstring, and calf muscles of the right hind leg. Mice in external fixator group received an external fixator following ACL reconstruction. Mice were monitored for survival, tolerance, and achievement of complete knee immobilization. All mice were meant for sacrifice on day 14 postoperatively. No perceptible change in gait was observed with 0.25 unit of Botox. All mice that received 0.5 unit of Botox had complete hind limb paralysis documented by footprint analysis 2 days after injection but failed to tolerate anesthesia and were euthanized 24 hours after operation due to their critical condition. In contrast, the external fixator was well tolerated and effectively immobilized the limb. There was a single occurrence of intraoperative technical error in the external fixator group that led to euthanasia. No mechanical failure or complication was observed. Botox paralysis was not a viable option for postoperative restriction of motion and joint loading in mice. However, external fixation was an effective method for complete knee immobilization and can be used in murine models requiring postoperative control of knee loading. This study introduces a robust research tool to allow control of postoperative joint loading in animal models such as ACL reconstruction, permitting study of the effects of mechanical load on the biologic aspects of tendon-to-bone healing.
Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production
Authors: Morita Kaoru , Okamura Tomohisa , Inoue Mariko , Komai Toshihiko , Teruya Shuzo , Iwasaki Yukiko , Sumitomo Shuji , Shoda Hirofumi , Yamamoto Kazuhiko , Fujio Keishi 
Published: December 2016

SignificanceTranscription factors early growth response gene 2 (Egr2) and Egr3 have long been regarded as negative regulators of T-cell activation.Egr2is also known as a susceptibility gene for systemic lupus erythematosus characterized by dysregulated humoral immune responses to autoantigens. Previously, we reported that Egr2-expressing CD4+CD25-LAG3+regulatory T cells regulate lupus pathogenesis via production of TGF-β3. However, the role of Egr2 and Egr3 in the regulation of humoral immunity is unclear. Here we report that Egr2 and Egr3 regulate germinal center reactions by promoting TGF-β3 production from regulatory T cells. Egr2 and Egr3 induce the expression of latent TGF-β binding protein 3 (Ltbp3), which is required for TGF-β3 secretion. These findings suggest that Egr2 and Egr3 in T cells may be potential novel therapeutic targets for autoantibody-mediated autoimmune diseases.
O-GlcNAc glycosylation stoichiometry of the FET protein family: only EWS is glycosylated with a high stoichiometry
Authors: Kamemura Kazuo 
Published: December 2016

Abstract
Of the FET (fused in sarcoma [FUS]/Ewing sarcoma protein [EWS]/TATA binding protein-associated factor 15 [TAF15]) family of heterogeneous nuclear ribonucleoprotein particle proteins, FUS and TAF15 are consistently and EWS variably found in inclusion bodies in neurodegenerative diseases such as frontotemporal lobar degeneration associated with FUS. It is speculated that dysregulation of FET proteins at the post-translational level is involved in their cytoplasmic deposition. Here, the O-linked β-N-acetylglucosamine (O-GlcNAc) glycosylation stoichiometry of the FET proteins was chemoenzymatically analyzed, and it was found that only EWS is dynamically glycosylated with a high stoichiometry in the neural cell lines tested and in mouse brain. It was also confirmed that EWS, but not FUS and TAF15, is glycosylated with a high stoichiometry not only in the neural cells but also in the non-neural cell lines tested. These results indicate that O-GlcNAc glycosylation imparts a physicochemical property on EWS that is distinct from that of the other FET proteins in most of cell lineages or tissues.
AGN feedback and the origin of the α enhancement in early-type galaxies – insights from the GAEA model
Authors: De Lucia Gabriella , Fontanot Fabio , Hirschmann Michaela 
Published: December 2016

Abstract
We take advantage of our recently published model for GAlaxy Evolution and Assembly (GAEA) to study the origin of the observed correlation between [α/Fe] and galaxy stellar mass. In particular, we analyse the role of radio-mode active galactic nuclei (AGN) feedback, which recent work has identified as a crucial ingredient to reproduce observations. In GAEA, this process introduces the observed trend of star formation histories extending over shorter time-scales for more massive galaxies, but does not provide a sufficient condition to reproduce the observed α enhancements of massive galaxies. In the framework of our model, this is possible only by assuming that any residual star formation is truncated for galaxies more massive than 1010.5 M⊙. This results, however, in even shorter star formation time-scales for the most massive galaxies, which translate in total stellar metallicities significantly lower than observed. Our results demonstrate that (i) trends of [α/Fe] ratios cannot be simply converted into relative time-scale indicators; and (ii) AGN feedback cannot explain alone the positive correlation between [α/Fe] and galaxy mass/velocity dispersion. Reproducing simultaneously the mass–metallicity relation and the α enhancements observed pose a challenge for hierarchical models, unless more exotic solutions are adopted such as metal-rich winds or a variable initial mass function.
Quality of Life and Sexual Distress in Women With Erosive Vulvovaginal Lichen Planus
Authors: Cheng Harriet , Oakley Amanda , Conaglen John V. , Conaglen Helen M. 
Published: December 2016

Objectives
Erosive vulvovaginal lichen planus (EVLP) is a chronic and painful genital dermatosis. Little is published about its impact on quality of life. This study aimed to evaluate quality of life and sexual function in women with EVLP.

Materials and Methods
Women with genital dermatoses were surveyed using the Dermatology Life Quality Index (DLQI) and Hospital Depression and Anxiety Scales. A subgroup completed the Female Sexual Distress Scale and Female Sexual Function Index subscales. Patient characteristics including age, diagnosis, and current treatment were recorded. Results from women with EVLP were compared with other diagnoses.

Results
Data from 77 women who participated between March 2013 and March 2014 were analyzed. Of these, 17 had EVLP. Comparator groups included women with vulval lichen sclerosus (n = 48) and vulval dermatitis (n = 12). In women with EVLP, 59% reported at least moderate impact on quality of life; mean DLQI scores: EVLP, 7.18; lichen sclerosus, 3.79; dermatitis, 8.67; p = .008. Overall, scores suggested depression in 14% and anxiety in 16% of participants. Sexual distress scores 11 or higher were recorded by 69% of women with EVLP, 63% of women with lichen sclerosus, and 56% of women with dermatitis. In those completing all sections of the survey (n = 40), DLQI was significantly correlated with depression (p = .004), sexual distress (p = .001), and sexual satisfaction (p = .01).

Conclusions
Sixty-nine percent of women with EVLP reported sexual distress. Women with EVLP reported lesser quality of life than those with lichen sclerosus. Quality of life, anxiety and depression, sexual distress, and sexual function were all related in these participants.
Understanding Interrater Reliability and Validity of Risk Assessment Tools Used to Predict Adverse Clinical Events
Authors: Siedlecki Sandra L. , Albert Nancy M. 
Published: December 2016

Purpose:
This article will describe how to assess interrater reliability and validity of risk assessment tools, using easy-to-follow formulas, and to provide calculations that demonstrate principles discussed.

Description:
Clinical nurse specialists should be able to identify risk assessment tools that provide high-quality interrater reliability and the highest validity for predicting true events of importance to clinical settings. Making best practice recommendations for assessment tool use is critical to high-quality patient care and safe practices that impact patient outcomes and nursing resources. Optimal risk assessment tool selection requires knowledge about interrater reliability and tool validity.

Outcome:
The clinical nurse specialist will understand the reliability and validity issues associated with risk assessment tools, and be able to evaluate tools using basic calculations.

Conclusion:
Risk assessment tools are developed to objectively predict quality and safety events and ultimately reduce the risk of event occurrence through preventive interventions. To ensure high-quality tool use, clinical nurse specialists must critically assess tool properties. The better the tool's ability to predict adverse events, the more likely that event risk is mediated. Interrater reliability and validity assessment is relatively an easy skill to master and will result in better decisions when selecting or making recommendations for risk assessment tool use.
Safety Profile of Children in an Enclosure Bed
Authors: Sherburne Eileen , Snethen Julia A. , Kelber Sheryl 
Published: December 2016

Purpose:
Pediatric nurses care for many children in the hospital setting whose behavioral challenges can impact safety. One intervention utilized to prevent injury and improve safety when caring for this population of children has been the enclosure bed. Scant information was found in the literature that discusses the use of the enclosure bed in the pediatric setting. The purpose of this article is to examine the use of the enclosure bed in the pediatric setting. A secondary aim is to identify the population of children where an enclosure bed was implemented and the safety factors associated with use of the enclosure bed.

Methods:
An exploratory retrospective chart review was conducted of 208 pediatric enclosure bed encounters in an acute care setting over a 2-year period. Variables included demographics, length of stay and bed use, behavioral medications, restraint and sitter usage, skin breakdown, fall risk, and falls.

Results:
Three categories of children based on cognitive function, no cognitive impairment, new cognitive impairment, and congenital cognitive impairment, were extracted from the chart review. Significant differences were found between groups of children and between safety variables observed with enclosure bed use. Children with new-onset cognitive impairment were more likely to incur falls, skin breakdown, and injury during use of the enclosure bed.

Conclusion:
Use of the enclosure bed is a reasonable intervention in certain children to ensure their safety in the hospital setting. This information will enhance nursing knowledge related to providing safe and optimal care of this challenging population of children.
Reduced Length of Stay and Adverse Events Using Bier Block for Forearm Fracture Reduction in the Pediatric Emergency Department
Authors: Fauteux-Lamarre Emmanuelle , Burstein Brett , Cheng Adam , Bretholz Adam 
Published: December 2016

Objectives
Forearm fractures are among the most common pediatric injuries. Procedural sedation is frequently used for analgesia during fracture reduction but requires a prolonged recovery period and can be associated with adverse events. Bier block is a safe alternative for fracture reduction analgesia. This study sought to compare Bier block and procedural sedation for forearm fracture reduction.

Methods
We performed a retrospective study of patients aged 6 to 18 years, presenting with forearm fractures requiring closed reduction from June 2012 to March 2014. Outcomes assessed were emergency department length of stay, reduction success rates, adverse events, and unscheduled return visits.

Results
Overall, 274 patients were included (Bier block, n = 109; procedural sedation, n = 165). Mean length of stay was 82 minutes shorter for Bier block patients (279 vs 361 minutes, P < 0.001). Subanalysis revealed a reduced length of stay among Bier block patients with forearm fractures involving a single bone (286 vs 388 minutes, P < 0.001) and both bones (259 vs 321 minutes, P < 0.05). Reduction success did not differ between Bier block and procedural sedation (98.2% vs 97.6%, P = 0.74). There were no major adverse events in either group, but Bier block patients experienced fewer minor adverse events (2.7% vs 14.5%, P < 0.001). Return visit rates were similar between Bier block and procedural sedation (17.6% vs 16.9%, P = 0.92).

Conclusions
Compared with procedural sedation, forearm fracture reduction performed with Bier block was associated with a reduced emergency department length of stay and fewer adverse events, with no differences in reduction success or return visits.
Optic neuritis: the eye as a window to the brain
Authors: Jenkins Thomas M. , Toosy Ahmed T. 
Published: December 2016

Purpose of review
Acute optic neuritis is a common clinical problem, requiring a structured assessment to guide management and prevent visual loss. The optic nerve is the most accessible part of the central nervous system, so optic neuritis also represents an important paradigm to help decipher mechanisms of damage and recovery in the central nervous system. Important developments include the advent of optical coherence tomography as a biomarker of central nervous system axonal loss, the discovery of new pathological antibodies, notably against aquaporin-4 and, more recently, myelin oligodendrocyte protein, and emerging evidence for sodium channel blockade as a novel therapeutic approach to address energy failure in neuroinflammatory disease.

Recent findings
We will present a practical approach to assessment of optic neuritis, highlighting the role of optical coherence tomography, when to test for new antibodies and the results of recent trials of sodium channel blockers.

Summary
Optic neuritis remains a clinical diagnosis; increasingly optical coherence tomography is a key ancillary investigation. Patients with ‘typical’ optic neuritis, commonly a first presentation of multiple sclerosis, must be distinguished from ‘atypical’ optic neuritis, who require testing for new pathological antibodies and require more aggressive-targeted treatment. Sodium channel blockade is an emerging and novel potential therapeutic pathway in neuroinflammatory disease.
I3S Classic and Insect Species Identification of Diptera and Hymenoptera (Mosquitoes and Bees)
Authors: Vyas-Patel Nayna , Mumford John D 
Published: December 2016

AbstractA number of image recognition systems have been specifically formulated for the individual recognition of large animals. These programs are versatile and can easily be adapted for the identification of smaller individuals such as insects. The Interactive Individual Identification System, I3S Classic, initially produced for the identification of individual whale sharks was employed to distinguish between different species of mosquitoes and bees, utilising the distinctive vein pattern present on insect wings. I3S Classic proved to be highly effective and accurate in identifying different species and sexes of mosquitoes and bees, with 80% to100% accuracy for the majority of the species tested. The sibling speciesApis melliferaandApis mellifera carnicawere both identified with100% accuracy.Bombus terrestris terrestrisandBombus terrestris audax; were also identified and separated with high degrees of accuracy (90% to 100% respectively for the fore wings and 100% for the hind wings). When bothAnopheles gambiaesensu stricto andAnopheles arabiensiswere present in the database, they were identified with 94% and 100% accuracy respectively, allowing for a morphological and non-molecular method of sorting between these members of the sibling complex. Flat, not folded and entire, rather than broken, wing specimens were required for accurate identification. Only one wing image of each sex was required in the database to retrieve high levels of accurate results in the majority of species tested. The study describes how I3S was used to identify different insect species and draws comparisons with the use of the CO1 algorithm. As with CO1, I3S Classic proved to be suitable software which could reliably be used to aid the accurate identification of insect species. It is emphasised that image recognition for insect species should always be used in conjunction with other identifying characters in addition to the wings, as is the norm when identifying species using traditional taxonomic keys.
Valence biases factual and counterfactual learning in opposite directions
Authors: Palminteri Stefano , Lefebvre Germain , Kilford Emma J. , Blakemore Sarah-Jayne 
Published: December 2016

AbstractPrevious studies suggest thatfactuallearning, that is, learning from obtained outcomes, is biased, such that participants preferentially take into account positive, as compared to negative, prediction errors. However, whether or not the prediction error valence also affectscounterfactuallearning, that is, learning from forgone outcomes, is unknown. To address this question, we analysed the performance of two cohorts of participants on reinforcement learning tasks using a computational model that was adapted to test if prediction error valance influences learning. Concerning factual learning, we replicated previous findings of a valence-induced bias, whereby participants learned preferentially from positive, relative to negative, prediction errors. In contrast, for counterfactual learning, we found the opposite valence-induced bias: negative prediction errors were preferentially taken into account relative to positive ones. When considering valence-induced bias in the context of both factual and counterfactual learning, it appears that people tend to preferentially take into account information that confirms their current choice
Recurring functional interactions predict network architecture of interictal and ictal states in neocortical epilepsy
Authors: Khambhati Ankit N. , Bassett Danielle S. , Oommen Brian S. , Chen Stephanie H. , Lucas Timothy H. , Davis Kathryn A. , Litt Brian 
Published: December 2016

AbstractHuman epilepsy patients suffer from spontaneous seizures, which originate in brain regions that also subserve normal function. Prior studies demonstrate focal, neocortical epilepsy is associated with dysfunction, several hours before seizures. How does the epileptic network perpetuate dysfunction during baseline periods? To address this question, we developed an unsupervised machine learning technique to disentangle patterns of functional interactions between brain regions, or subgraphs, from dynamic functional networks constructed from approximately 100 hours of intracranial recordings in each of 22 neocortical epilepsy patients. Using this approach, we found: (i) subgraphs from ictal (seizure) and interictal (baseline) epochs are topologically similar, (ii) interictal subgraph topology and dynamics can predict brain regions that generate seizures, and (iii) subgraphs undergo slower and more coordinated fluctuations during ictal epochs compared to interictal epochs. Our observations suggest that the epileptic network drives dysfunction by controlling dynamics of functional interactions between brain regions that generate seizures and those that underlie normal function.
Prolonged time taken to complete the degree programmes at the Faculty of Engineering Technology of the Open University of Sri Lanka
Authors: Aluwihare Shriyangi , De Silva Shammi 
Published: December 2016

Purpose
It has been observed that the students attending the bachelor’s degree programmes offered by the Faculty of Engineering Technology (FET) at the Open University of Sri Lanka (OUSL) take extraordinarily longer period to complete their degrees. The purpose of this paper is to identify the institutional barrier, student-related personal barrier and psychological barrier behind the prolonged duration of completion of the said degrees.

Design/methodology/approach
A well-developed questionnaire was administered among a selected sample of graduates who were awarded the Bachelor of Technology (Engineering) and Bachelor of Industrial Studies degrees within the past ten years.

Findings
Results indicate that institutional barriers such as poor academic counselling and guidance; laboratory sessions being inappropriate/not sufficient to understand the course material; inadequate facilities, such as library resources, and lack of laboratory facilities at the regional centres have contributed immensely to the lengthy duration taken to complete the degrees. Personal factors such as work-related challenges, travelling time and cost of commuting to the main centre located in Colombo and inability to spend the required time expected of the programme have played major roles in the prolonged completion. Results indicate that the cost of tuition is not a major barrier for on-time completion. Psychological barriers such as possessing a limited repertoire of study strategies, lack of understanding of open and distance learning (ODL) methods and deficiency of continuous motivation had a tremendous impact on the delayed graduation. A high satisfaction rate was observed regarding the ODL tools that were used within the programmes and the formative and summative evaluation criteria. Approximately 75 per cent of the sample approved of the five remedies suggested.

Originality/value
Findings of this study provide insight for shortening the duration of the bachelor’s degree programmes offered by the FET at the OUSL.