bluuebunny/crossref_metadata_2025_split huggingface dataset:
The DEAD box RNA helicase Ddx39a is essential for myocyte and lens development in zebrafish
Authors: Zhang Linlin , Li Beibei , Yang Yuxi , Scott Ian C. , Lou Xin 
Published: October 2017

AbstractRNA helicases from the DEAD-box family are found in almost all organisms and have important roles in RNA metabolism including RNA synthesis, processing and degradation. The function and mechanism of action of most of these helicases in animal development and human disease are largely unexplored. In a zebrafish mutagenesis screen to identify genes essential for heart development we identified a zebrafish mutant, which disrupts the gene encoding the RNA helicase DEAD-box 39a (ddx39a).Homozygous ddx39a mutant embryos exhibit profound cardiac and trunk muscle dystrophy, along with lens abnormalities caused by abrupt terminal differentiation of cardiomyocyte, myoblast and lens fiber cells. Further investigation indicated that loss of ddx39a hindered mRNA splicing of members of the kmt2 gene family, leading to mis-regulation of structural gene expression in cardiomyocyte, myoblast and lens fiber cells. Taken together, these results show that Ddx39a plays an essential role in establishment of proper epigenetic status during cell differentiation.
Unbiased association and expression studies identify novel genes for tooth development
Authors: Williams Meredith A. , Biguetti Claudia , Romero-Bustillos Miguel , Maheshwari Kanwal , Dinckan Nuriye , Cavalla Franco , Liu Xiaoming , Silva Renato , Akyalcin Sercan , Uyguner Z Oya , Vieira Alexandre R. , Amendt Brad A. , Fakhrouri Walid D , Letra Ariadne 
Published: October 2017

AbstractPreviously reported co-occurrence of colorectal cancer (CRC) and tooth agenesis (TA) and the overlap in disease-associated gene variants suggest involvement of similar molecular pathways. In this study, we took an unbiased approach and tested genome-wide significant CRC-associated variants for association with isolated TA. Thirty single nucleotide variants (SNVs) in CRC-predisposing genes/loci were genotyped in a discovery dataset composed of 440 individuals with and without isolated TA. Genome-wide significant associations were found between TA andDUSP10rs6687758 (P=1.25 × 10−9) andATF1rs11169552 (P=4.36 × 10−10), with strong association found withCASC8rs10505477 (P=8.2 × 10−5). Additional CRC marker haplotypes were also significantly associated with TA (P<0.0002). Genotyping an independent dataset consisting of 52 cases with TA and 427 controls confirmed the association withCASC8.Atf1 and Dusp10 expression was detected in the mouse developing teeth from early bud stages to the formation of the complete tooth, suggesting a potential role for these genes and their encoded proteins in tooth development. Our findings suggest Atf1 and Dusp10 as new tooth development genes, while having a role in colorectal cancer. While their individual contributions in tooth development remain to be elucidated, these genes may be considered additional candidates to be tested in future human genetic studies.
Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms
Authors: McClenaghan Conor , Hanson Alex , Sala-Rabanal Monica , Roessler Helen I. , Josifova Dragana , Grange Dorothy K. , Haaften Gijs van , Nichols Colin G. 
Published: October 2017

AbstractThe complex cardiovascular disorder Cantu Syndrome arises from gain-of-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels. Recent reports indicate that such mutations can increase channel activity by multiple molecular mechanisms. In this study, we determine the mechanism by which KATP function is altered by several mutations in distinct structural domains of SUR2: D207E in the intracellular L0-linker and Y985S, G989E, M1060I, and R1154Q/W in TMD2. Mutations were engineered at their equivalent position in rat SUR2A (D207E, Y981S, G985E, M1056I and R1150Q/W) and functional effects were investigated using macroscopic rubidium (86Rb+) efflux assays and patch clamp electrophysiology. The results show that D207E increases KATP activity by increasing intrinsic stability of the open state, whilst the cluster of Y981S/G985E/M1056I mutations, as well as R1150Q/W, augment Mg-nucleotide activation. The response of mutant channels to inhibition by the sulfonylurea drug glibenclamide, a potential pharmacotherapy for CS, was also tested. There was no major effect on glibenclamide sensitivity for the D207E, Y981S, G985E or M1056I mutations, but glutamine and tryptophan substitution at R1150 resulted in significant decreases in potency.
From mixed embeddedness to transnational mixed embeddedness
Authors: Bagwell Susan 
Published: October 2017

PurposeThe purpose of this paper is to investigate the relevance of the mixed embeddedness thesis (Kloosterman, 2010; Rath and Kloosterman, 2002) to businesses with a more transnational mode of operation.Design/methodology/approachInterviews with the owner managers of a sample 24 Vietnamese businesses in London were undertaken to develop an understanding of how micro (individual resources: social, financial and cultural/human capital, and history of migration), meso (local, regional and national markets) and macro (politico-institutional) factors in the UK and overseas influenced business development.FindingsThe findings illustrate how business development is influenced not just by the interaction of the local (UK) opportunity structure and the entrepreneur’s resources, as suggested by the mixed embeddedness thesis, but also by institutional regimes, economies and markets in key countries of the diaspora, and the interaction of these. The extent to which new transnational opportunities can be exploited, however, depends on access to the necessary local and transnational forms of capital.Practical implicationsThe empirical evidence presented is used to present a re-working of the mixed embeddedness thesis to provide a framework for understanding the drivers of transnational entrepreneurship.Originality/valueThe paper presents new empirical knowledge of transnational activity amongst the UK Vietnamese business community – a little known refugee community. Conceptually, the paper offers a theoretical development of the mixed embeddedness thesis to enable it to provide an explanation of transnational entrepreneurship amongst new migrant communities.
Exploring the evolution of ethnic entrepreneurship: the case of Brazilian immigrants in Florida
Authors: Cruz Eduardo Picanço , Falcao Roberto Pessoa Queiroz , Barreto Cesar Ramos 
Published: October 2017

PurposeThe purpose of this paper is to analyze Brazilian entrepreneurial communities in Florida, through the capitals theory approach.Design/methodology/approachBy adopting a comparative case study approach, the researchers conducted 80 in-depth interviews with Brazilian entrepreneurs in two different communities – Pompano Beach (Miami area) and Orlando, Florida. Data triangulation was performed through interviews with community stakeholders, secondary sources of data and surveys.FindingsAuthors propose a framework of 27 contexts, based on immigrant entrepreneurs’ capital provisions. Evidence points to different evolutionary paths of the two communities of Brazilian immigrants that were compared. Some of these contexts were found in other ethnicities from extant literature, which shows that it might be generalizable to other cases.Research limitations/implicationsThe limitations relate to the fact that the comparative study was conducted in one ethnic group. Nevertheless, the paper brings insights to support future studies on immigrant and ethnic entrepreneurship as a building block for future comparative studies on other immigrant communities.Practical implicationsThe work presents a guideline for future entrepreneurs in Florida.Social implicationsImplications of practice will arise after further studies in the contexts of economic, human and social capital. The cases of successful immigrant communities enlightened by the capitals theory might be useful to newly born ethnic enclaves.Originality/valueThe originality of the paper lies on the comparison of two entrepreneurial communities of the same ethnicity in Florida, showing different behaviors due to the internal and environmental factors. Moreover, the Brazilian entrepreneur’s particularities add up to the general theory of immigrant or ethnic entrepreneurship.
Health, happiness and your future: using a “men’s group” format to work with homeless men in London
Authors: Thompson Kate , Brown Pippa , Vieira Stephanie 
Published: October 2017

PurposeThe purpose of this paper is to describe an intervention with a group of homeless men from the Horn of Africa, service users of the Horn of Africa Health and Wellbeing Project in London. The group was conceived by the second author who noted the presence of significant psychosocial issues for her clients, but equally their reluctance to access mainstream mental health or social care services.Design/methodology/approachDesigning the group and introducing it to the men involved threw up some challenges which are explored, and the impact of the group on participants is evaluated.FindingsOverall both the participants and the facilitators evaluated the group positively and it appeared to have led to lasting change for some of the group members, and this is described. The authors argue that this sort of group may be a more acceptable way to work on psychosocial issues than something more directly focused on mental health intervention. The group protocol is outlined along with suggestions for future work in this area.Originality/valueThis intervention represents a creative alternative to more mainstream psychological interventions for homeless or exiled men.
Identifying “best bets” for searching in chemical engineering
Authors: Badia Giovanna 
Published: October 2017

PurposePerforming efficient literature searches and subscribing to the most comprehensive databases for interdisciplinary fields can be challenging since the literature is typically indexed in numerous databases to different extents. Comparing databases will help information professionals make appropriate choices when teaching, literature searching, creating online subject guides, and deciding which databases to renew when faced with fiscal challenges. The purpose of this paper is to compare databases for searching the chemical engineering literature.Design/methodology/approachThis paper compares journal indexing and search recall across seven databases that cover the chemical engineering literature in order to determine which database and database pair provide the most comprehensive coverage in this area. It also summarizes published, database comparison methods to aid information professionals in undertaking their own comparative assessments.FindingsSciFinder, Scopus, and Web of Science, listed alphabetically, were the leading databases for searching the chemical engineering literature. SciFinder-Scopus and SciFinder-Web of Science were the top two database pairs. No single database or pair provided 100 percent complete coverage of the literature examined. Searching a second database increased the recall of results by an average of 17.6 percent.Practical implicationsThe findings are useful since they identify “best bets” for performing an efficient search of the chemical engineering literature. Information professionals can also use the methods discussed to compare databases for any discipline or search topic.Originality/valueThis paper builds on the previous literature by using a dual approach to compare the coverage of the chemical engineering literature across multiple databases. To the author’s knowledge, comparing databases in the field of chemical engineering has not been reported in the literature thus far.
Bringing out the everyday in everyday information behavior
Authors: Ocepek Melissa G. 
Published: October 2017

PurposeThe purpose of this paper is to argue that scholars in the information behavior (IB) field should embrace the theoretical framework of the everyday to explore a more holistic view of IB.Design/methodology/approachThe paper describes the theory of the everyday and delineates four opportunities offered by scholars of the everyday. The paper concludes with three examples that highlight what a more everyday-focused everyday information behavior might look like.FindingsThe theory of the everyday provides a useful theoretical framework to ground research addressing the everyday world as well as useful concepts for analysis and research methodology.Originality/valueThe theoretical framework of the everyday contributes to IB research by providing a theoretical justification for work addressing everyday life as well as useful concepts for analysis. The paper also outlines the benefits of integrating methods influenced by institutional ethnography, a methodology previously used to address the nuances of the everyday world.
Remittance inflows and starting a business
Authors: Gautam Durga Prasad 
Published: October 2017

Purpose
Political economy research recognizes that the inflows of external financial resources help the governments enact market-oriented reforms. Since remittances have outpaced other types of financial inflows in many countries, they can potentially increase the government’s incentive to implement regulatory reform that can contribute to business-friendly environment. This issue has long been overlooked by the literature on remittances. The purpose of this paper is to examine whether remittances promote business regulatory reform in the recipient countries.

Design/methodology/approach
This study uses balance of payments data on remittances for 114 countries during 2004-2012 period. Since remittances could be endogenous to business regulation, the identification strategy follows an instrumental variable approach. The author assesses the general stability of linear model estimates by fitting the beta regression model.

Findings
The results show that, while the increase in remittance inflows is associated with lower regulatory requirements for starting a business in the recipient economy, this association is stronger in developing countries than in high-income nations. Various sensitivity tests reinforce the robustness of these findings.

Originality/value
One of the most important yet overlooked aspects of remittances is that they can potentially shape the political will to enact regulatory reform for businesses. The incentives for the government to relax burdensome entry regulations tend to stem from potential gains associated with the formalization of remittances. This paper makes a first attempt at studying the link between remittances and the quality of entry regulation.
Using predictive decisionmaking to implement technology prizes
Authors: Youngberg David 
Published: October 2017

Purpose
The purpose of this paper is to propose a system for regularly offered government-sponsored technology prizes. Such prizes would preserve the incentive to invent without the barriers to entry that come with the patent system. This is of particular interest to entrepreneurs as they lack the patent portfolio that incumbent firms can leverage into derivative technology.

Design/methodology/approach
After reviewing various efficiency concerns with the patent system, the author describes how technology prizes could work alongside the patent system. Such prizes are best when the sponsor can capture as much of the technology spillover as possible – i.e. through a government agency. This paper provides a framework for a practical prize structure while paying special attention to combating the logistical and public choice concerns of creating a prize.

Findings
This paper focuses on two methods to prevent inefficiency in government-sponsored prize: truth-bonding and information markets. Each mechanism helps combat different kinds of problems. Various complications to this system are explored and addressed.

Practical implications
The paper suggests that an efficient prize system is a possible policy and, if implemented, would embolden technology-focused entrepreneurship and other subsequent technological development.

Originality/value
While previous work has noted the benefits of technology prizes over patents, few attempts have been made to outline an incentive-compatible system for doing so. This paper is the first of its kind to propose a practical and efficient government-sponsored prize system.
The entrepreneurship-unemployment nexus in Croatia
Authors: Payne James E. , Mervar Andrea 
Published: October 2017

PurposeThe purpose of this paper is to extend the literature on the entrepreneurship-unemployment nexus to the case of Croatia.Design/methodology/approachThe study uses the Toda-Yamamoto causality test within a vector autoregressive model to determine the causal dynamics between the self-employment rate (SER), unemployment rate (UR), industrial production, and credit in the case of Croatia from March 1998 to December 2016.FindingsThe results reveal support for the recession-push hypothesis. Specifically, the authors find that an increase in the UR Granger causes an increase in the SER.Research limitations/implicationsDue to data availability, a more detailed analysis of self-employment by industry was prohibitive.Practical implicationsThe results emphasize the importance of recognizing business cycle dynamics and the availability of credit when evaluating the causal relationship between entrepreneurship and unemployment.Social implicationsAs policy makers view entrepreneurship as a potential remedy for unemployment, particular attention needs to be given to both the phases of the business cycle and credit availability to support entrepreneurial ventures in the design of policy.Originality/valuePrevious studies on the causal dynamics between entrepreneurship and unemployment pertain to OECD countries. This is the first study to examine a transition economy recently admitted to the European Union.
The impact of labor freedom on geographic cost of living differentials
Authors: Cebula Richard , Payne James E. , Horner Donnie , Boylan Robert 
Published: October 2017

PurposeThe purpose of this paper is to examine the impact of labor market freedom on state-level cost of living differentials in the USA using cross-sectional data for 2016 after allowing for the impacts of economic and quality of life factors.Design/methodology/approachThe study uses two-stage least squares estimation controlling for factors contributing to cost of living differences across states.FindingsThe results reveal that an increase in labor market freedom reduces the overall cost of living.Research limitations/implicationsThe study can be extended using panel data and alternative measures of labor market freedom.Practical implicationsIn general, the finding that less intrusive government and greater labor freedom are associated with a reduced cost of living should not be surprising. This is because less government intrusion and greater labor freedom both inherently allow markets to be more efficient in the rationalization of and interplay with forces of supply and demand.Social implicationsThe findings of this and future related studies could prove very useful to policy makers and entrepreneurs, as well as small business owners and public corporations of all sizes – particularly those considering either location in, relocation to, or expansion into other markets within the USA. Furthermore, the potential benefits of the National Right-to-Work Law currently under consideration in Congress could add cost of living reductions to the debate.Originality/valueThe authors extend the literature on cost of living differentials by investigating whether higher amounts of state-level labor market freedom act to reduce the states’ cost of living using the most recent annual data available (2016). That labor freedom has a systemic efficiency impact on the state-level cost of living is a significant finding. In our opinion, it is likely that labor market freedom is increasing the efficiency of labor market transactions in the production and distribution of goods and services, and acts to reduce the cost of living in states. In addition, unlike previous related studies, the authors investigate the impact of not only overall labor market freedom on the state-level cost of living, but also how the three sub-indices of labor market freedom, as identified and measured by Stanselet al.(2014, 2015), impact the cost of living state by state.
Proxy advisory voting recommendations in India – an exploratory study
Authors: Subramanian S. 
Published: October 2017

PurposeThis paper aims to explore the voting recommendations made by proxy advisory firms in India by descriptively analyzing the “Vote Against” recommendations made by two proxy advisory firms for shareholder resolutions for the listed Indian firms. It also empirically tests the relationship between proportion of “Vote Against” recommendations and the parameters which are proved to be influencing corporate governance practices of a firm.Design/methodology/approachEmpirical analysis of proxy voting recommendations for a sample of 77 listed non-financial Indian firms across four financial years.FindingsThe paper finds that two categories of shareholders proposals, “reappointment of non-executive directors” and “remuneration of statutory auditors”, account for 83.5 per cent of “Vote Against” recommendations. Further, there are significant differences in the proportion of “Vote Against” recommendations based on the type of “controlling ownership” of the firms. The regression analysis indicates that the relationships between proportion of “Vote Against” recommendations and determinants of corporate governance practices are mostly in line with the a priori expectations, as far as ownership is concerned but requires further analysis for other parameters.Research limitations/implicationsExploratory nature of this paper opens up new research issues in the upcoming Indian Proxy advisory industry. It suggests that the future research should consider the controlling ownership as an important parameter while analyzing the proxy firm recommendations.Practical implicationsIndian proxy advisory industry requires lots of nurturing from the regulators, and this exploratory study provides the basic insights in this regard. It also highlights potential corporate governance issues where the regulators need to tighten the corporate governance norms, like reappointment of independent directors and appointment of statutory auditors.Originality/valuePioneering Study in understanding the proxy advisory voting recommendations in an emerging market.