bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chebulinic acid inhibits smooth muscle cell migration by suppressing PDGF-Rβ phosphorylation and inhibiting matrix metalloproteinase-2 expression
Authors: Song In-Sung , Jeong Yu Jeong , Park Jung-Hyun , Shim Sungbo , Jang Sung-Wuk 
Published: September 2017

AbstractExcessive migration of vascular smooth muscle cells (VSMCs) after vascular injury contributes to the development of occlusive vascular disease. Inhibition of VSMC migration is a validated therapeutic modality for occlusive vascular diseases, such as atherosclerosis and restenosis. We investigated the inhibitory effect of chebulinic acid (CBA) on cell migration and matrix metalloproteinase (MMP)-2 activation in platelet-derived growth factor (PDGF)-BB-induced mouse and human VSMCs. CBA significantly inhibited PDGF-BB-induced migration in mouse and human VSMCs, without inducing cell death. Additionally, CBA significantly blocked PDGF-BB-induced phosphorylation of the PDGF receptor (PDGF-R), Akt, and extracellular signal-regulated kinase (ERK)1/2 by inhibiting the activation of the PDGF-BB signalling pathway. In both mouse and human VSMCs, CBA inhibited PDGF-induced MMP-2 mRNA and protein expression as well as the proteolytic activity of MMP-2. Moreover, CBA suppressed sprout outgrowth formation of VSMCs from endothelium-removed aortic rings as well as neointima formation following rat carotid balloon injury. Taken together, our findings indicated that CBA inhibits VSMC migration by decreasing MMP-2 expression through PDGF-R and the ERK1/2 and Akt pathways. Our data may improve the understanding of the antiatherogenic effects of CBA in VSMCs.
A Novel Mouse Model of Traumatic Optic Neuropathy Using External Ultrasound Energy to Achieve Focal, Indirect Optic Nerve Injury
Authors: Tao Wensi , Dvoriantchikova Galina , Tse Brian C. , Pappas Steven , Chou Tsung-Han , Tapia Manuel , Porciatti Vittorio , Ivanov Dmitry , Tse David T. , Pelaez Daniel 
Published: September 2017

AbstractTraumatic optic neuropathy (TON) is a devastating cause of permanent visual loss following blunt injury to the head. Animal models for TON exist, but most fail to recapitulate the clinical scenario of closed head indirect trauma to the nerve and subsequent neurodegeneration. Thus, we developed a clinically-relevant animal model for TON using a novel ultrasonic pulse injury modality (sonication-induced TON; SI-TON). To trigger TON, a microtip probe sonifier was placed on the supraorbital ridge directly above the entrance of the optic nerve into the bony canal. An ultrasonic pulse was then delivered to the optic nerve. After injury, the number of RGCs in the retina as well as visual function measured by PERG steadily decreased over a two-week period. In the optic nerve, pro-inflammatory markers were upregulated within 6 hours following injury. Immunohistochemistry showed activation of microglia and infiltration of CD45-positive leukocytes in the optic nerve and initiation of a gliotic response. The SI-TON model is capable of delivering a non-contact concussive injury to the optic nerve and induce TON in mice. Thus, our data indicate that the SI-TON model reliably recapitulates the pathophysiology and progressive neurodegeneration seen in the human manifestation.
Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light
Authors: Einspahr Janine G. , Curiel-Lewandrowski Clara , Calvert Valerie S. , Stratton Steven P. , Alberts David S. , Warneke James , Hu Chengcheng , Saboda Kathylynn , Wagener Elisabeth L. , Dickinson Sally , Dong Zigang , Bode Ann M. , Petricoin Emanuel F. 
Published: September 2017

AbstractUltraviolet radiation is an important etiologic factor in skin cancer and a better understanding of how solar stimulated light (SSL) affects signal transduction pathways in human skin which is needed in further understanding activated networks that could be targeted for skin cancer prevention. We utilized Reverse Phase Protein Microarray Analysis (RPPA), a powerful technology that allows for broad-scale and quantitative measurement of the activation/phosphorylation state of hundreds of key signaling proteins and protein pathways in sun-protected skin after an acute dose of two minimal erythema dose (MED) of SSL. RPPA analysis was used to map the altered cell signaling networks resulting from acute doses of solar simulated radiation (SSL). To that end, we exposed sun-protected skin in volunteers to acute doses of two MED of SSL and collected biopsies pre-SSL and post-SSL irradiation. Frozen biopsies were subjected to laser capture microdissection (LCM) and then assessed by RPPA. The activation/phosphorylation or total levels of 128 key signaling proteins and drug targets were selected for statistical analysis. Coordinate network-based analysis was performed on specific signaling pathways that included the PI3k/Akt/mTOR and Ras/Raf/MEK/ERK pathways. Overall, we found early and sustained activation of the PI3K-AKT-mTOR and MAPK pathways. Cell death and apoptosis-related proteins were activated at 5 and 24 h. Ultimately, expression profile patterns of phosphorylated proteins in the epidermal growth factor receptor(EGFR), AKT, mTOR, and other relevant pathways may be used to determine pharmacodynamic activity of new and selective topical chemoprevention agents administered in a test area exposed to SSL to determine drug-induced attenuation or reversal of skin carcinogenesis pathways.
Fish and fishery historical data since the 19th century in the Adriatic Sea, Mediterranean
Authors: Fortibuoni Tomaso , Libralato Simone , Arneri Enrico , Giovanardi Otello , Solidoro Cosimo , Raicevich Saša 
Published: September 2017

AbstractHistoric data on biodiversity provide the context for present observations and allow studying long-term changes in marine populations. Here we present multiple datasets on fish and fisheries of the Adriatic Sea covering the last two centuries encompassing from qualitative observations to standardised scientific monitoring. The datasets consist of three groups: (1) early naturalists’ descriptions of fish fauna, including information (e.g., presence, perceived abundance, size) on 255 fish species for the period 1818–1936; (2) historical landings from major Northern Adriatic fish markets (Venice, Trieste, Rijeka) for the period 1902–1968, Italian official landings for the Northern and Central Adriatic (1953–2012) and landings from the Lagoon of Venice (1945–2001); (3) trawl-survey data from seven surveys spanning the period 1948–1991 and including Catch per Unit of Effort data (kgh−1 and/or nh−1) for 956 hauls performed at 301 stations. The integration of these datasets has already demonstrated to be useful to analyse historical marine community changes over time, and its availability through open-source data portal will facilitate analyses in the framework of marine historical ecology.
Database of multi-parametric geophysical data from the TOMO-DEC experiment on Deception Island, Antarctica
Authors: Ibáñez Jesús M. , Díaz-Moreno Alejandro , Prudencio Janire , Zandomeneghi Daria , Wilcock William , Barclay Andrew , Almendros Javier , Benítez Carmen , García-Yeguas Araceli , Alguacil Gerardo 
Published: September 2017

AbstractDeception Island volcano (Antarctica) is one of the most closely monitored and studied volcanoes on the region. In January 2005, a multi-parametric international experiment was conducted that encompassed both Deception Island and its surrounding waters. We performed this experiment from aboard the Spanish oceanographic vessel ‘Hespérides’, and from five land-based locations on Deception Island (the Spanish scientific Antarctic base ‘Gabriel de Castilla’ and four temporary camps). This experiment allowed us to record active seismic signals using a large network of seismic stations that were deployed both on land and on the seafloor. In addition, other geophysical data were acquired, including bathymetric high precision multi-beam data, and gravimetric and magnetic profiles. To date, the seismic and bathymetric data have been analysed but the magnetic and gravimetric data have not. We provide P-wave arrival-time picks and seismic tomography results in velocity and attenuation. In this manuscript, we describe the main characteristics of the experiment, the instruments, the data, and the repositories from which data and information can be obtained.
Disrupted cortical brain network in post-traumatic stress disorder patients: a resting-state electroencephalographic study
Authors: Shim M , Im C-H , Lee S-H 
Published: September 2017

AbstractThis study aimed to examine the source-level cortical brain networks of post-traumatic stress disorder (PTSD) based on the graph theory using electroencephalography (EEG). Sixty-six cortical source signals were estimated from 78 PTSD and 58 healthy controls (HCs) of resting-state EEG. Four global indices (strength, clustering coefficient (CC), path length (PL) and efficiency) and one nodal index (CC) were evaluated in six frequency bands (delta, theta, alpha, low beta, high beta and gamma). PTSD showed decreased global strength, CC and efficiency, in delta, theta, and low beta band and enhanced PL in theta and low beta band. In low beta band, the strength and CC correlated positively with the anxiety scores, while PL had a negative correlation. In addition, nodal CCs were reduced in PTSD in delta, theta and low beta band. Nodal CCs of theta band correlated negatively with rumination and re-experience symptom scores; while, nodal CCs in low beta band correlated positively with anxiety and pain severity. Inefficiently altered and symptom-dependent changes in cortical networks were seen in PTSD. Our source-level cortical network indices might be promising biomarkers for evaluating PTSD.
Relevance of the Implementation of Teeth in Three-Dimensional Vocal Tract Models
Authors: Traser Louisa , Birkholz Peter , Flügge Tabea Viktoria , Kamberger Robert , Burdumy Michael , Richter Bernhard , Korvink Jan Gerrit , Echternach Matthias 
Published: September 2017

Purpose
Recently, efforts have been made to investigate the vocal tract using magnetic resonance imaging (MRI). Due to technical limitations, teeth were omitted in many previous studies on vocal tract acoustics. However, the knowledge of how teeth influence vocal tract acoustics might be important in order to estimate the necessity of implementing teeth in vocal tract models. The aim of this study was therefore to estimate the effect of teeth on vocal tract acoustics.

Method

The acoustic properties of 18 solid (3-dimensional printed) vocal tract models without teeth were compared to the same 18 models including teeth in terms of resonance frequencies (
f
Rn
). The
f
Rn
were obtained from the transfer functions of these models excited by white noise at the glottis level. The models were derived from MRI data of 2 trained singers performing 3 different vowel conditions (/i/, /a/, and /u/) in speech and low-pitched and high-pitched singing.

Results
Depending on the oral configuration, models exhibiting side cavities or side branches were characterized by major changes in the transfer function when teeth were implemented via the introduction of pole-zero pairs.

Conclusions
To avoid errors in modeling, teeth should be included in 3-dimensional vocal tract models for acoustic evaluation.

Supplemental Material

https://doi.org/10.23641/asha.5386771
Writing in Two Children With Autism: A Case Study for Assessment and Goal Development
Authors: Koutsoftas Anthony D. 
Published: September 2017

PurposeWriting is an important consideration for children with an Autistic Spectrum Disorder (ASD), especially when included in general education environments. This case study of an inclusive classroom provides a comprehensive description of writing processes allowing for demonstration of an assessment procedure and goal development. The case studied is a 6th grade inclusion classroom whereby 2 students were included and diagnosed with an ASD, their typically developing classmates served as a control group.MethodOne 6th grade classroom participated in this study and included 2 children receiving services for ASD and 15 classmates. Children completed a 3-day writing process task whereby they planned, wrote, and revised a narrative story on three separate days.ResultsIndividual writing profiles of children with ASD revealed writing process skills consistent with each child's cognitive-linguistic learning profile.DiscussionFindings from this study highlight the need to use cognitive linguistic profiles alongside writing samples to develop appropriate and attainable IEP goals for children with ASD. Implications for assessment, IEP goal development, and future directions for research and intervention are provided with particular focus on inclusive classroom settings.
Pituitary Adenoma Presenting As Trigeminal Neuralgia
Authors: Wani Abrar , Ramzan Altaf , Khan Abdul , Malik Nayil , Pervez Khalid 
Published: September 2017

AbstractCompression of trigeminal nerve in cavernous sinus leading to trigeminal neuralgia is one of the rare presentations of pituitary tumor. We report a patient whose presenting complaint was trigeminal neuralgia in V1, V2 distribution and he had pituitary macroadenoma invading ipsilateral cavernous sinus. After surgery, the neuralgia disappeared completely.
Breaking International Barriers: #ColorectalSurgery Is #GlobalSurgery
Authors: Otero Jaime , Mayol Julio 
Published: September 2017

AbstractColorectal surgeons have lagged behind other professionals in the use of social media. Currently, Twitter is the most widely utilized social platform for professional purposes among them. Connection and contagion are the two key actions that, together with immediate feedback and quantifiable impact, favor the use of Twitter over other social networks. In early 2016, a group of colorectal surgeons launched the #colorectalsurgery hashtag and, in less than 1 year, the ecosystem has incorporated over 2,600 users that generated over 24,000 tweets and 100 million impressions. “Live-Tweeting” surgical conferences by attendees including institutional or society accounts have greatly contributed to the success of the initiative. However, there are some barriers to a more wide adoption of social media, such as misrepresentation of non–peer-reviewed data, challenges to intellectual property protection, or even damage to the professional image. Active engagement with the #colorectalsurgery community may result in benefits for the global surgery community through information sharing, social interactions, personal branding, and research.
Targeted Epidural Blood Patch Treatment for Refractory Spontaneous Intracranial Hypotension in China
Authors: He Fei-Fang , Li Li , Liu Min-Jun , Zhong Tai-Di , Zhang Qiao-Wei , Fang Xiang-Ming 
Published: September 2017

Objective An epidural blood patch (EBP) is the mainstay of treatment for refractory spontaneous intracranial hypotension (SIH). We evaluated the treatment efficacy of targeted EBP in refractory SIH.
Methods All patients underwent brain magnetic resonance imaging (MRI) with contrast and heavily T2-weighted spine MRI. Whole spine computed tomography (CT) myelography with non-ionic contrast was performed in 46 patients, and whole spine MR myelography with intrathecal gadolinium was performed in 119 patients. Targeted EBPs were placed in the prone position one or two vertebral levels below the cerebrospinal fluid (CSF) leaks. Repeat EBPs were offered at 1-week intervals to patients with persistent symptoms, continued CSF leakage, or with multiple leakage sites.
Results Brain MRIs showed pachymeningeal enhancement in 127 patients and subdural hematomas in 32 patients. One hundred fifty-two patients had CSF leakages on heavily T2-weighted spine MRIs. CSF leaks were also detected on CT and MR myelography in 43 and 111 patients, respectively. Good recovery was achieved in all patients after targeted EBP. No serious complications occurred in patients treated with targeted EBP during the 1 to 7 years of follow-up.
Conclusions Targeted and repeat EBPs are rational choices for treatment of refractory SIH caused by CSF leakage.
Timing of Maternal Tobacco Exposure, Hypertension, and Risk of Singleton Small-For-Gestational Age Infants
Authors: Kirby Russell , Luke Sabrina 
Published: September 2017

Objective Small-for-gestational age infants are at an increased risk for disabilities and chronic health problems. Smoking and hypertension during pregnancy pose significant risks for fetal growth restriction. The study aims to identify whether (1) the timing of tobacco use modifies the risk of small-for-gestational age, (2) there are differences in association by percentile of small-for-gestational age (3rd, 5th, and 10th percentile), and (3) the effect of tobacco exposure on small-for-gestational age outcome is mediated by hypertension.
Materials and Methods Data were obtained from the 2009 Natality public use file available through the National Center for Health Statistics. Women were categorized into 11 groups depending on the trimester of tobacco exposure, the number of daily cigarettes smoked, and presence of hypertension. Multivariable log-linear regression models were performed to determine the association between percentile of singleton small-for-gestational age outcome (3rd, 5th, and 10th), trimester and degree of tobacco exposure, and hypertension.
Results Hypertension and smoking worked synergistically to restrict fetal growth. Hypertensive women who smoked heavily in all three trimesters were 4.34 times more likely to give birth to a 3rd percentile small-for-gestational age infant compared with nonsmoking normotensive women.
Conclusion The timing and duration of tobacco exposure mediates the risk and severity of fetal growth restriction.
Efectividad del tratamiento de la enfermedad de Dupuytren (ED) mediante fasciotomía enzimática con colagenasa. Estudio multicéntrico cohortes prospectivo
Authors: Olea A. , Dudley A. F. , Andrade M. D. , Ocampos M. , Fahandezh-Saddi H. , Del Cerro M. 
Published: September 2017

Objetivos: Se ha realizado un estudio prospectivo multicéntrico con el objetivo de evaluar la efectividad del tratamiento de la enfermedad de Dupuytren (ED) con colagenasa mediante la medición de la corrección de la contractura en flexión de las articulaciones tratadas con colagenasa y la tasa de recidivas al mes, 6 y 12 meses.Material y métodos: Se evaluaron los sujetos que presentasen contractura de 20º o mayor en articulaciones metacarpofalángicas (MCF) o interfalángicas proximales (IFP). Se recogieron datos al mes, 6 y 12 meses postinfiltración. Se compararon las medias entre grados de contractura y su evolución en el tiempo.Resultados: Los casos con afectación exclusiva MCF sumaron 58, su contractura media fue de 50º. Los pacientes tratados de IFP fueron 16, su contractura media fue de 64º. Aquellos que tenían patología en ambas articulaciones fueron 52 casos. La MCF obtuvo una extensión completa al mes en el 80% y la IFP en el 66% de casos con contractura menor de 50º. La MCF y el 33% de las IFP menor de 40º mantuvieron la corrección al año.Conclusiones: Los autores recomiendan el tratamiento mediante colagenasa en pacientes que presentan contractura en flexión de un solo dedo y que afecta a la articulación MCF.
Application of Graphene and its Derivatives in Cancer Diagnosis and Treatment
Authors: Ghanbarzadeh S. , Hamishehkar H. 
Published: September 2017

AbstractAlthough chemotherapies are successful in some cases, systemic toxicity could be simultaneously observed due to the lack of drugs selectivity to cancerous tissues, leading to the failure of the chemotherapies. Furthermore, the therapeutic effects will be significantly improved if the anticancer drugs could be delivered to cancer cells with high selectivity. In recent years, there have been many advances in the field of diagnosis and treatment of cancer as a result of the development of novel materials with noticeable and often unique properties. Nanoparticles have unique biological properties, owing to their small size and large surface area-to-volume ratio, which allow them to bind, absorb, and carry compounds such as small molecule drugs, DNA, RNA, proteins, and probes with high efficiency. In the course of the last decade, Graphene and its derivatives have attracted growing interest in medicinal and pharmaceutical sciences, and many studies have focused on the potential of Graphene and its derivatives as carriers for targeted drug delivery intended for cancer diagnosis and therapies. In the present study, we will review the characteistics and application of Graphene and its different derivatives and finally discuss the opportunities, limitations, and challenges in this encouraging field.
Use
of the over-the-scope-clip (OTSC) in non-variceal upper gastrointestinal
bleeding in patients with severe cardiovascular comorbidities: a retrospective
study
Authors: Wedi Edris , von Renteln Daniel , Gonzalez Susana , Tkachenko Olena , Jung Carlo , Orkut Sinan , Roth Victor , Tumay Selin , Hochberger Juergen 
Published: September 2017

Abstract
Introduction The over-the-scope-clip (OTSC) can potentially overcome
limitations of standard clips and achieve more efficient and reliable
hemostasis. Data on OTSC use for non-variceal upper gastrointestinal bleeding
(NVUGIB) in patients with cardiovascular comorbidities are currently limited.
Patients and methods We prospectively collected and retrospectively
analyzed our database from February 2009 to September 2015 from all patients who
underwent emergency endoscopy for high-risk NVUGIB in 2 academic centers and
were treated with OTSC as first-line (n = 81) or second-line therapy (n = 19).
Results One hundred patients mean age 72 (range 27 – 97 years) were
included in this study. Fifty-one percent (n = 51) had severe cardiovascular
co-morbidity (ischemic heart disease, congestive heart failure, hypertension,
valvular heart disease, peripheral arterial occlusive disease and atrial
fibrillation) and 73 % (n = 73) were on antiplatelet or/and anticoagulation
therapy. The median size of the treated ulcers was 3 cm (range 1 – 5 cm). In
94 % (n = 94) primary hemostasis with OTSC was achieved. Clinical long-term
success during a mean 6-month follow-up without rebleeding was 86 % (n = 86).
Conclusions In this cohort OTSC was demonstrated to be a safe and
effective first- or second-line treatment for NVUGIB in high-risk patients with
cardiovascular disease and complex, large ulcers. Meeting presentations:
Annual Meeting of the German Society of Endoscopy (DEGBV) in Mannheim, Germany,
March 17th–19th, 2016 and DDW 2016 in San Diego, United
States
Effectiveness and safety of metallic stent for ileocecal obstructive colon cancer: a report of 4 cases
Authors: Ishii Tatsuya , Minaga Kosuke , Ogawa Satoshi , Ikenouchi Maiko , Yoshikawa Tomoe , Akamatsu Takuji , Seta Takeshi , Urai Shunji , Uenoyama Yoshito , Yamashita Yukitaka 
Published: September 2017

Abstract
Background and study aims Self-expandable metallic stents (SEMS) have been widely used for left-sided colorectal obstruction. Few studies on SEMS placement for right-sided colonic obstructions have been reported because stenting in the right colon is technically difficult, particularly in the ileocecal region. We present 4 cases of successful bridge-to-surgery stenting for ileocecal cancer. Using an endoscopic retrograde cholangiopancreatography catheter with a movable tip and a decompression tube was effective for stenting. No adverse events occurred during or after SEMS placement in any of these cases. Short-term stenting for ileocecal cancer seems to be effective and safe.