bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimizing civilian harm in populated areas: Lessons from examining ISAF and AMISOM policies
Authors: Muhammedally Sahr 
Published: February 2017

AbstractBoth the African Union Mission in Somalia (AMISOM) and the International Security Assistance Force (ISAF) – the North Atlantic Treaty Organization's security assistance mission to Afghanistan – have recognized the importance of reducing civilian harm, and adopted policies and practices that restrict the use of certain weapons in populated areas. ISAF commanders issued a number of tactical directives that restricted the use of certain air-delivered weapons, and AMISOM developed an indirect fire policy limiting the use of artillery and other indirect fire munitions in populated areas. This article examines both ISAF and AMISOM policies and practices to reduce civilian harm in populated areas and explores how these policies strengthened adherence to international humanitarian law and illustrated new ways in which armed actors can take feasible precautions and prioritize civilian protection.
Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer
Authors: Delaney Joe Ryan , Patel Chandni B. , Willis Katelyn McCabe , Haghighiabyaneh Mina , Axelrod Joshua , Tancioni Isabelle , Lu Dan , Bapat Jaidev , Young Shanique , Cadassou Octavia , Bartakova Alena , Sheth Parthiv , Haft Carley , Hui Sandra , Saenz Cheryl , Schlaepfer David D. , Harismendy Olivier , Stupack Dwayne G. 
Published: February 2017

AbstractIdentification of specific oncogenic gene changes has enabled the modern generation of targeted cancer therapeutics. In high-grade serous ovarian cancer (OV), the bulk of genetic changes is not somatic point mutations, but rather somatic copy-number alterations (SCNAs). The impact of SCNAs on tumour biology remains poorly understood. Here we build haploinsufficiency network analyses to identify which SCNA patterns are most disruptive in OV. Of all KEGG pathways (N=187), autophagy is the most significantly disrupted by coincident gene deletions. Compared with 20 other cancer types, OV is most severely disrupted in autophagy and in compensatory proteostasis pathways. Network analysis prioritizes MAP1LC3B (LC3) and BECN1 as most impactful. Knockdown of LC3 and BECN1 expression confers sensitivity to cells undergoing autophagic stress independent of platinum resistance status. The results support the use of pathway network tools to evaluate how the copy-number landscape of a tumour may guide therapy.
Giant heat transfer in the crossover regime between conduction and radiation
Authors: Kloppstech Konstantin , Könne Nils , Biehs Svend-Age , Rodriguez Alejandro W. , Worbes Ludwig , Hellmann David , Kittel Achim 
Published: February 2017

AbstractHeat is transferred by radiation between two well-separated bodies at temperatures of finite difference in vacuum. At large distances the heat transfer can be described by black body radiation, at shorter distances evanescent modes start to contribute, and at separations comparable to inter-atomic spacing the transition to heat conduction should take place. We report on quantitative measurements of the near-field mediated heat flux between a gold coated near-field scanning thermal microscope tip and a planar gold sample at nanometre distances of 0.2–7 nm. We find an extraordinary large heat flux which is more than five orders of magnitude larger than black body radiation and four orders of magnitude larger than the values predicted by conventional theory of fluctuational electrodynamics. Different theories of phonon tunnelling are not able to describe the observations in a satisfactory way. The findings demand modified or even new models of heat transfer across vacuum gaps at nanometre distances.
Demonstration of qubit operations below a rigorous fault tolerance threshold with gate set tomography
Authors: Blume-Kohout Robin , Gamble John King , Nielsen Erik , Rudinger Kenneth , Mizrahi Jonathan , Fortier Kevin , Maunz Peter 
Published: February 2017

AbstractQuantum information processors promise fast algorithms for problems inaccessible to classical computers. But since qubits are noisy and error-prone, they will depend on fault-tolerant quantum error correction (FTQEC) to compute reliably. Quantum error correction can protect against general noise if—and only if—the error in each physical qubit operation is smaller than a certain threshold. The threshold for general errors is quantified by their diamond norm. Until now, qubits have been assessed primarily by randomized benchmarking, which reports a different error rate that is not sensitive to all errors, and cannot be compared directly to diamond norm thresholds. Here we use gate set tomography to completely characterize operations on a trapped-Yb+-ion qubit and demonstrate with greater than 95% confidence that they satisfy a rigorous threshold for FTQEC (diamond norm ≤6.7 × 10−4).
Call to action: improving primary care for women with COPD
Authors: Tsiligianni Ioanna , Rodríguez Miguel Román , Lisspers Karin , LeeTan Tze , Infantino Antonio 
Published: February 2017

AbstractIn this perspective-based article, which is based on findings from a comprehensive literature search, we discuss the significant and growing burden of chronic obstructive pulmonary disease in women worldwide. Chronic obstructive pulmonary disease now affects both men and women almost equally. Despite this, there remains an outdated perception of chronic obstructive pulmonary disease as a male-dominated disease. Primary care physicians play a central role in overseeing the multidisciplinary care of women with chronic obstructive pulmonary disease. Many women with chronic obstructive pulmonary disease delay seeking medical assistance, due to fear of stigmatization or dismissing symptoms as a ‘smoker’s cough’. Improving awareness is important to encourage women with symptoms to seek advice earlier. Once women do seek help, primary care physicians need to have knowledge of the nuances of female chronic obstructive pulmonary disease disease presentation to avoid mis- or delayed diagnosis, both of which are more common in women with chronic obstructive pulmonary disease than men. Subsequent management should consider gender-specific issues, such as differential incidences of comorbid conditions, potentially higher symptom burden, and a higher risk of exacerbations. Chronic obstructive pulmonary disease treatment and smoking cessation management should be specifically tailored to the individual woman and reviewed regularly to optimize patient outcomes. Finally, education should be an integral part of managing chronic obstructive pulmonary disease in women as it will help to empower them to take control of their disease.
Comparisons of aerosol backscatter using satellite and ground lidars: implications for calibrating and validating spaceborne lidar
Authors: Gimmestad Gary , Forrister Haviland , Grigas Tomas , O’Dowd Colin 
Published: February 2017

AbstractThe Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) instrument on the polar orbiter Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) is an elastic backscatter lidar that produces a global uniformly-calibrated aerosol data set. Several Calibration/Validation (Cal/Val) studies for CALIOP conducted with ground-based lidars and CALIOP data showed large aerosol profile disagreements, both random and systematic. In an attempt to better understand these problems, we undertook a series of ground-based lidar measurements in Atlanta, Georgia, which did not provide better agreement with CALIOP data than the earlier efforts, but rather prompted us to investigate the statistical limitations of such comparisons. Meaningful Cal/Val requires intercomparison data sets with small enough uncertainties to provide a check on the maximum expected calibration error. For CALIOP total attenuated backscatter, reducing the noise to the required level requires averaging profiles along the ground track for distances of at least 1,500 km. Representative comparison profiles often cannot be acquired with ground-based lidars because spatial aerosol inhomogeneities introduce systematic error into the averages. These conclusions have implications for future satellite lidar Cal/Val efforts, because planned satellite lidars measuring aerosol backscatter, wind vector, and CO2 concentration profiles may all produce data requiring considerable along-track averaging for meaningful Cal/Val.
Finite-temperature scaling of trace distance discord near criticality in spin diamond structure
Authors: Cheng W. W. , Wang X. Y. , Sheng Y. B. , Gong L. Y. , Zhao S. M. , Liu J. M. 
Published: February 2017

AbstractIn this work we explore the quantum correlation quantified by trace distance discord as a measure to analyze the quantum critical behaviors in the Ising-XXZ diamond structure at finite temperatures. It is found that the first-order derivative of the trace distance discord exhibits a maximum around the critical point at finite temperatures. By analyzing the finite-temperature scaling behavior, we show that such a quantum correlation can detect exactly the quantum phase transitions from the entan-gled state in ferrimagnetic phase to an unentangled state in ferrimagnetic phase or to an unentangled state in ferromagnetic phase. The results also indicate that the above two kinds of transitions can be distinguished by the different finite-temperature scaling behaviors. Moreover, we find that the trace distance discord, in contrast to other typical quantum correlations (e.g., concurrence, quantum discord and Hellinger distance), may be more reliable to exactly spotlight the critical points of this model at finite temperatures under certain situations.
Re-shifting the ecological baseline for the overexploited Mediterranean red coral
Authors: Garrabou J. , Sala E. , Linares C. , Ledoux J. B. , Montero-Serra I. , Dominici J. M. , Kipson S. , Teixidó N. , Cebrian E. , Kersting D. K. , Harmelin J. G. 
Published: February 2017

AbstractOverexploitation leads to the ecological extinction of many oceanic species. The depletion of historical abundances of large animals, such as whales and sea turtles, is well known. However, the magnitude of the historical overfishing of exploited invertebrates is unclear. The lack of rigorous baseline data limits the implementation of efficient management and conservation plans in the marine realm. The precious Mediterranean red coralCorallium rubrumhas been intensively exploited since antiquity for its use in jewellery. It shows dramatic signs of overexploitation, with no untouched populations known in shallow waters. Here, we report the discovery of an exceptional red coral population from a previously unexplored shallow underwater cave in Corsica (France) harbouring the largest biomass (by more than 100-fold) reported to date in the Mediterranean. Our findings challenge current assumptions on the pristine state of this emblematic species. Our results suggest that, before intense exploitation, red coral lived in relatively high-density populations with a large proportion of centuries-old colonies, even at very shallow depths. We call for the re-evaluation of the baseline for red coral and question the sustainability of the exploitation of a species that is still common but ecologically (functionally) extinct and in a trajectory of further decline.
Hemispheric differences between left and right supramarginal gyrus for pitch and rhythm memory
Authors: Schaal Nora K. , Pollok Bettina , Banissy Michael J. 
Published: February 2017

AbstractFunctional brain imaging studies and non-invasive brain stimulation methods have shown the importance of the left supramarginal gyrus (SMG) for pitch memory. The extent to which this brain region plays a crucial role in memory for other auditory material remains unclear. Here, we sought to investigate the role of the left and right SMG in pitch and rhythm memory in non-musicians. Anodal or sham transcranial direct current stimulation (tDCS) was applied over the left SMG (Experiment 1) and right SMG (Experiment 2) in two different sessions. In each session participants completed a pitch and rhythm recognition memory task immediately after tDCS. A significant facilitation of pitch memory was revealed when anodal stimulation was applied over the left SMG. No significant effects on pitch memory were found for anodal tDCS over the right SMG or sham condition. For rhythm memory the opposite pattern was found; anodal tDCS over the right SMG led to an improvement in performance, but anodal tDCS over the left SMG had no significant effect. These results highlight a different hemispheric involvement of the SMG in auditory memory processing depending on auditory material that is encoded.
Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1)
Authors: Chung Felicia Fei-Lei , Tan Perry Faith Tze Ming , Raja Vijay Joseph , Tan Boon-Shing , Lim Kuan-Hon , Kam Toh-Seok , Hii Ling-Wei , Tan Si Hoey , See Sze-Jia , Tan Yuen-Fen , Wong Li-Zhe , Yam Wai Keat , Mai Chun Wai , Bradshaw Tracey D. , Leong Chee-Onn 
Published: February 2017

AbstractPrecursor mRNA (pre-mRNA) splicing is catalyzed by a large ribonucleoprotein complex known as the spliceosome. Numerous studies have indicated that aberrant splicing patterns or mutations in spliceosome components, including the splicing factor 3b subunit 1 (SF3B1), are associated with hallmark cancer phenotypes. This has led to the identification and development of small molecules with spliceosome-modulating activity as potential anticancer agents. Jerantinine A (JA) is a novel indole alkaloid which displays potent anti-proliferative activities against human cancer cell lines by inhibiting tubulin polymerization and inducing G2/M cell cycle arrest. Using a combined pooled-genome wide shRNA library screen and global proteomic profiling, we showed that JA targets the spliceosome by up-regulating SF3B1 and SF3B3 protein in breast cancer cells. Notably, JA induced significant tumor-specific cell death and a significant increase in unspliced pre-mRNAs. In contrast, depletion of endogenous SF3B1 abrogated the apoptotic effects, but not the G2/M cell cycle arrest induced by JA. Further analyses showed that JA stabilizes endogenous SF3B1 protein in breast cancer cells and induced dissociation of the protein from the nucleosome complex. Together, these results demonstrate that JA exerts its antitumor activity by targeting SF3B1 and SF3B3 in addition to its reported targeting of tubulin polymerization.
Plasmonic nanomeshes: their ambivalent role as transparent electrodes in organic solar cells
Authors: Stelling Christian , Singh Chetan R. , Karg Matthias , König Tobias A. F. , Thelakkat Mukundan , Retsch Markus 
Published: February 2017

AbstractIn this contribution, the optical losses and gains attributed to periodic nanohole array electrodes in polymer solar cells are systematically studied. For this, thin gold nanomeshes with hexagonally ordered holes and periodicities (P) ranging from 202 nm to 2560 nm are prepared by colloidal lithography. In combination with two different active layer materials (P3HT:PC61BM and PTB7:PC71BM), the optical properties are correlated with the power conversion efficiency (PCE) of the solar cells. A cavity mode is identified at the absorption edge of the active layer material. The resonance wavelength of this cavity mode is hardly defined by the nanomesh periodicity but rather by the absorption of the photoactive layer. This constitutes a fundamental dilemma when using nanomeshes as ITO replacement. The highest plasmonic enhancement requires small periodicities. This is accompanied by an overall low transmittance and high parasitic absorption losses. Consequently, larger periodicities with a less efficient cavity mode, yet lower absorptive losses were found to yield the highest PCE. Nevertheless, ITO-free solar cells reaching ~77% PCE compared to ITO reference devices are fabricated. Concomitantly, the benefits and drawbacks of this transparent nanomesh electrode are identified, which is of high relevance for future ITO replacement strategies.
GARP2 accelerates retinal degeneration in rod cGMP-gated cation channel β-subunit knockout mice
Authors: DeRamus Marci L. , Stacks Delores A. , Zhang Youwen , Huisingh Carrie E. , McGwin Gerald , Pittler Steven J. 
Published: February 2017

AbstractThe Cngb1 locus-encoded β-subunit of rod cGMP-gated cation channel and associated glutamic acid rich proteins (GARPs) are required for phototransduction, disk morphogenesis, and rod structural integrity. To probe individual protein structure/function of the GARPs, we have characterized several transgenic mouse lines selectively restoring GARPs on a Cngb1 knockout (X1−/−) mouse background. Optical coherence tomography (OCT), light and transmission electron microscopy (TEM), and electroretinography (ERG) were used to analyze 6 genotypes including WT at three and ten weeks postnatal. Comparison of aligned histology/OCT images demonstrated that GARP2 accelerates the rate of degeneration. ERG results are consistent with the structural analyses showing the greatest attenuation of function when GARP2 is present. Even 100-fold or more overexpression of GARP1 could not accelerate degeneration as rapidly as GARP2, and when co-expressed GARP1 attenuated the structural and functional deficits elicited by GARP2. These results indicate that the GARPs are not fully interchangeable and thus, likely have separate and distinct functions in the photoreceptor. We also present a uniform murine OCT layer naming nomenclature system that is consistent with human retina layer designations to standardize murine OCT, which will facilitate data evaluation across different laboratories.
Chilling Affects Phytohormone and Post-Embryonic Development Pathways during Bud Break and Fruit Set in Apple (Malus domestica Borkh.)
Authors: Kumar Gulshan , Gupta Khushboo , Pathania Shivalika , Swarnkar Mohit Kumar , Rattan Usha Kumari , Singh Gagandeep , Sharma Ram Kumar , Singh Anil Kumar 
Published: February 2017

AbstractThe availability of sufficient chilling during bud dormancy plays an important role in the subsequent yield and quality of apple fruit, whereas, insufficient chilling availability negatively impacts the apple production. The transcriptome profiling during bud dormancy release and initial fruit set under low and high chill conditions was performed using RNA-seq. The comparative high number of differentially expressed genes during bud break and fruit set under high chill condition indicates that chilling availability was associated with transcriptional reorganization. The comparative analysis reveals the differential expression of genes involved in phytohormone metabolism, particularly for Abscisic acid, gibberellic acid, ethylene, auxin and cytokinin. The expression of Dormancy Associated MADS-box, Flowering Locus C-like, Flowering Locus T-like and Terminal Flower 1-like genes was found to be modulated under differential chilling. The co-expression network analysis indentified two high chill specific modules that were found to be enriched for “post-embryonic development” GO terms. The network analysis also identified hub genes including Early flowering 7, RAF10, ZEP4 and F-box, which may be involved in regulating chilling-mediated dormancy release and fruit set. The results of transcriptome and co-expression network analysis indicate that chilling availability majorly regulates phytohormone-related pathways and post-embryonic development during bud break.
Influence of FKBP5 polymorphism and DNA methylation on structural changes of the brain in major depressive disorder
Authors: Han Kyu-Man , Won Eunsoo , Sim Youngbo , Kang June , Han Changsu , Kim Yong-Ku , Kim Seung-Hyun , Joe Sook-Haeng , Lee Min-Soo , Tae Woo-Suk , Ham Byung-Joo 
Published: February 2017

AbstractA single nucleotide polymorphism of rs1360780 in the FKBP5 gene is associated with a predisposition to developing major depressive disorder (MDD). We investigated the interactive effects of FKBP5 rs1360780 allelic variants, DNA methylation, and the diagnosis of MDD on structural changes of the entire brain. One hundred and fourteen patients with MDD and eighty-eight healthy controls underwent T1-weighted structural magnetic resonance imaging and FKBP5 rs1360780 genotyping, including DNA methylation of intron 7. We analyzed the volume of cortical and subcortical regions and cortical thickness using FreeSurfer. Significant genotype-by-diagnosis interactions were observed for volumes of the left pars triangularis, supramarginal gyrus, superior parietal lobule, right frontomarginal, and posterior midcingulate gyrus. The T allele was associated with significant volume reductions in these brain regions only in the MDD group except for the right posterior midcingulate gyrus. FKBP5 DNA methylation showed a positive correlation with the thickness of the right transverse frontopolar gyrus in the C allele homozygote group. Our findings suggest that the FKBP5 gene and its epigenetic changes could have influence on morphologic changes of several brain regions involved in emotion regulation, and that this process may be associated with the development of MDD.
Discovery of genes coding for carbohydrate-active enzyme by metagenomic analysis of lignocellulosic biomasses
Authors: Montella Salvatore , Ventorino Valeria , Lombard Vincent , Henrissat Bernard , Pepe Olimpia , Faraco Vincenza 
Published: February 2017

AbstractIn this study, a high-throughput sequencing approach was applied to discover novel biocatalysts for lignocellulose hydrolysis from three dedicated energy crops,Arundo donax, Eucalyptus camaldulensisandPopulus nigra, after natural biodegradation. The microbiomes of the three lignocellulosic biomasses were dominated by bacterial species (approximately 90%) with the highest representation by theStreptomycesgenus both in the total microbial community composition and in the microbial diversity related to GH families of predicted ORFs. Moreover, the functional clustering of the predicted ORFs showed a prevalence of poorly characterized genes, suggesting these lignocellulosic biomasses are potential sources of as yet unknown genes. 1.2%, 0.6% and 3.4% of the total ORFs detected inA. donax, E. camaldulensisandP. nigra,respectively, were putative Carbohydrate-Active Enzymes (CAZymes). Interestingly, the glycoside hydrolases abundance inP. nigra(1.8%) was higher than that detected in the other biomasses investigated in this study. Moreover, a high percentage of (hemi)cellulases with different activities and accessory enzymes (mannanases, polygalacturonases and feruloyl esterases) was detected, confirming that the three analyzed samples were a reservoir of diversified biocatalysts required for an effective lignocellulose saccharification.
Band-Engineered Local Cooling in Nanoscale Junctions
Authors: Hsu Bailey C. , Chen Yu-Chang 
Published: February 2017

AbstractThe stability and performance of nanoscale junctions are closely related to the local effective temperature. The local effective temperature is mainly caused by the competition between heating and cooling processes in inelastic electron-phonon scat- tering. Local cooling occurs when the rate of energy in cooling exceeds that in heating. Previous research has been done using either specific potential configuration or an adatom to achieve local cooling. We propose an engineer-able local-cooling mechanism in asymmetric two-terminal tunneling junctions, in which one electrode is made of metal, whereas the other is made of a selectable bad-metal, such as heavily-doped polysilicon. The width of energy window of the selectable material, defined as the width covering all possible energy states counting from the conduction band minimum, can be engineered through doping. Interestingly, we have shown that substantial local cooling can be achieved at room temperature when the width of energy window of the low-density electrode is comparable to the energy of the phonon. The unusual local cooling is caused by the narrowed width of energy window, which obstructs the inelastic scattering for heating.