bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internationalization and innovation in nascent companies: does gender matter?
Authors: Alves Marlon Fernandes Rodrigues , Galina Simone Vasconcelos Ribeiro , Macini Nayele , Cagica Carvalho Luísa , Costa Teresa 
Published: June 2017

Purpose
The purpose of this paper is to explore the competitiveness of women entrepreneurs in terms of internationalization and innovation. Supported by a resource-based framework of early internationalizing firms, the authors investigated multiple conditions for the relationship between internationalization and innovation relative to gender in nascent companies.

Design/methodology/approach
For this purpose, the authors used survey data related to entrepreneurial activity in 50 countries from the Global Entrepreneurship Monitor. Based on a model of seven factors (internationalization, innovation, gender, skills, opportunity, sector, and country), the authors tested the significance of the relationships between these factors by means of a hierarchical log-linear analysis.

Findings
The results indicate the low competitiveness of women entrepreneurs in general, but outline some singularities, especially between developed and developing countries.

Originality/value
This study offers cross-country empirical evidence of how factors of different levels interact with each other. In this way, the authors shed light on the competitiveness of nascent companies, especially regarding gender differences.
Institutional framework and entrepreneurial failure
Authors: García-Ramos Constantino , Gonzalez-Alvarez Nuria , Nieto Mariano 
Published: June 2017

PurposeThe purpose of this paper is to analyse the influence of the institutional environment on entrepreneurial failure of certain characteristics, both formal (regulatory complexity and tax pressure) and informal (social capital and fear of failure).Design/methodology/approachThe authors use data drawn from a panel of 37 countries over a period of nine years (2006-2014).FindingsResults show that the greater the regulatory complexity, the higher the rate of entrepreneurial failure; also that the higher the country’s stock of social capital, the lower the rate of entrepreneurial failure. Finally, the greater the tax pressure, the lower the rate of business failure.Research limitations/implicationsAmong the limitations of this paper is the difficulty of directly measuring the variables it analyses, making it necessary to use proxies.Practical implicationsThis study has important practical implications for policymakers. First, the study provides important insights on how regulatory complexity positively affects entrepreneurial failure. In other words, the study represents a response to the call for the development of a better regulatory environment since this plays a significant role in entrepreneurial failure. Second, regarding tax pressure, the authors found that the greater the tax pressure, the lower the rate of entrepreneurial failure. In this respect, entrepreneurs, academics and policymakers should be aware of this result. Finally, this study also demonstrates the important role of social capital in preventing entrepreneurial failure.Originality/valueIn line with the findings, this study provides proof of how the institutional framework can have an influence on entrepreneurial failure.
Taking conversations forward: a systemic exercise for teams threatened by service restructures
Authors: Randall‐James James , Head Annabel 
Published: June 2017

AbstractThis paper describes a systemic exercise for clinical staff facing multiple changes to team structure and threats to their sense of belonging. The exercise was adapted from a consultation intervention that addressed a team's resourcefulness in responding to behaviours that challenge in intellectual disabilities (Smyly, 2006). As clinical psychology trainees from outside the Child and Adolescent Mental Health Service (CAMHS), we aimed to facilitate a context in which staff could share past experiences of collectively overcoming challenges, and in this way nourish a sense of belonging. Through building layers of dialogue, taking the observer perspective and reflection in the context of such threats to personal, professional and team identities, a shared direction may be claimed again.Practitioner points

Providing space for teams to reflect on past experiences of overcoming challenging situations may empower teams and enhance a sense of belonging during difficult transitions
Moving towards an explorative and interactive space for personal and professional selves, away from problem‐saturated narratives, creates a context for innovation and change
Exercises that develop layers of conversation can scaffold relational risk‐taking, celebrate difference, and guide collaboration towards developing narratives of belonging
Identity, nostalgia and happiness among migrants: The case of the Kōshien High School Baseball Tournament in Japan
Authors: Yamamura Eiji 
Published: June 2017

AbstractPublic broadcasting of all games of high school baseball tournaments attests to their popularity in Japan. The present study uses individual‐level data to test the hypothesis that nostalgia influences the level of happiness of Japanese people. Its key findings were: (i) the number of wins by a prefecture team increased the happiness level of its residents; (ii) this effect applied only to residents of large cities; and (iii) for urban migrants, originally from rural areas, the effect of their home team wins exceeded that of the wins of their host area team. This effect was significant in cases where the host area cultural climate differed from that of the migrant home area. These findings suggest that a scarcity of ‘identity’ goods related to the residential community increases high school baseball influence on happiness. Furthermore, the influence of nostalgia for home on migrants’ happiness is greater than their attachment to their current residential community.
Long‐term risk of infection in patients with Crohn's disease on anti‐TNF treatment: A prospective single‐center cohort study in China
Authors: Li Yue , Shu Hui Jun , Lu Hong , Yang Hong , Li Ji , Tan Bei , Qian Jia Ming 
Published: June 2017

OBJECTIVEThe aim of this study was to explore the long‐term risk of infection in patients with Crohn's disease (CD) on infliximab (IFX) therapy.METHODSAll CD patients treated with IFX were recruited from January 2008 to December 2015. Their characteristics and infectious events during IFX therapy were prospectively collected, and the risk of infection was evaluated using Cox regression.RESULTSSeventy CD patients receiving IFX were consecutively recruited. During a median of 15 months, 15 patients experienced 17 infectious events which occurred within a median of 21 weeks after the initiation of IFX therapy. Of 17 infectious events, eight were viral infections, six were bacterial infections, and the others were fungal infections. IFX was discontinued in 6 (40.0%) out of 15 cases due to infections. Compared with those without infections, patients with infectious events were more likely of Montreal B1 (inflammatory) behavior, with concomitant use of systemic corticosteroids when infliximab was started but less mucosal healing when infections occurred (P < 0.05). By Cox hazard ratio (HR) analysis, patients with B1 behavior had a higher risk of developing infections than those with B3 (fistulizing) behavior (HR 4.897, P = 0.010). Successful corticosteroid withdrawal (HR 0.275, P = 0.035) or mucosal healing (HR 0.155, P = 0.002) were associated with a lower risk of infections.CONCLUSIONSLong‐term use of IFX in CD patients has a high risk of infections. Failure in mucosal healing and increased concomitant use of systemic corticosteroids are independent risk factors of infections during IFX therapy.
A free ride? An analysis of the association of casino bus tours and problem gambling among older adults
Authors: van der Maas Mark , Mann Robert E. , Matheson Flora I. , Turner Nigel E. , Hamilton Hayley A. , McCready John 
Published: June 2017

AbstractBackground and aimsLittle research has examined the relationship between incentives used by gambling venues to attract customers and the experience of gambling‐related harm. Organized and subsidized bus tours are a common example of such incentives. The aim of this study was to examine whether bus‐tour patronage was associated with increased odds of problem gambling among older adults. This study also compared rates of bus‐tour use by socio‐demographic characteristics and gambling behaviours.DesignPearson's χ2 tests and Mann–Whitney U‐tests were applied for bivariate analyses. Multivariate generalized mixed‐effects regression modelling was used to examine the relationship between bus‐tour patronage and problem gambling while controlling for possible confounding factors.SettingSeven gambling venues located in Central and Southwestern Ontario, Canada.ParticipantsA total of 1978 gambling venue patrons over the age of 55 years.MeasurementsProblem gambling as indicated by the Problem Gambling Severity Index, bus‐tour patronage in the 12 months prior to the survey, spending per gambling visit and past‐month slot machine participation.FindingsRegression analyses showed that bus‐tour patronage was associated with higher odds of problem gambling [odds ratio (OR) = 1.71, confidence interval (CI) = 1.06, 2.76] after controlling for several demographic characteristics, type of gambling and gambling expenditures. Bivariate analyses showed past‐year bus‐tour patronage was associated with more frequent slot machine play (χ2 = 48.16, P < 0.001), more past‐year gambling venue visits (P < 0.001) and lower spending on gambling per casino visit (P < 0.001). Compared with non‐patrons, bus tour patrons were more likely to be female (χ2 = 21.92, P < 0.001), born outside Canada (χ2 = 113.18, P < 0.001), above the age of 75 (χ2 = 24.02, P < 0.001) and retired (χ2 = 16.60, P < 0.001).ConclusionsWhen adjusting for potential confounders among older adults, using bus tours to access Canadian gambling venues is associated with increased risk of problem gambling. Bus‐tour patrons are more likely to be female, born outside Canada and above the age of 75 years.
Childhood traumatic experiences and the association with marijuana and cocaine use in adolescence through adulthood
Authors: Scheidell Joy D. , Quinn Kelly , McGorray Susan P. , Frueh B. Christopher , Beharie Nisha N. , Cottler Linda B. , Khan Maria R. 
Published: June 2017

AbstractBackground and aimsExamination of longitudinal relationships between childhood traumatic experiences and drug use across the life‐course at the national level, with control of confounding by other forms of trauma, is needed. We aimed to estimate the prevalence of nine typologies of childhood traumas and the cumulative number experienced, correlation between traumas and associations between individual and cumulative number of traumas with drug use during adolescence, emerging adulthood and adulthood.DesignSecondary data analysis using the National Longitudinal Study of Adolescent to Adult Health.SettingUnited States.ParticipantsA nationally representative sample of individuals in grades 7–12 (aged 11–21 years) during 1994–95, who were re‐interviewed during emerging adulthood (2001–02; aged 18–28) and adulthood (2007–08; aged 24–34). The analytical sample comprised 12 288 participants with data at all three waves.MeasurementsNine typologies of childhood traumas: neglect; emotional, physical and sexual abuse; parental incarceration and binge drinking; and witnessing, being threatened with and experiencing violence. Indicators of each were summed to measure cumulative dose. Outcomes were marijuana and cocaine use during adolescence, emerging adulthood and adulthood.FindingsApproximately half experienced at least one childhood trauma; traumas were not highly correlated. We observed a dose–response relationship between the number of traumas and drug use in adolescence [marijuana, adjusted odds ratio (aOR) one trauma versus none = 1.65, 95% confidence interval (CI) = 1.42, 1.92; two traumas = 2.58, 95% CI = 2.17, 3.06; ≥ four traumas = 6.92, 95% CI = 5.17, 9.26; cocaine, aOR one trauma = 1.87, 95% CI = 1.23, 2.84; two traumas = 2.80, 95% CI = 1.74, 4.51; ≥ four traumas = 9.54, 95% CI = 5.93, 15.38]. Similar dose–response relationships with drug use were observed in emerging adulthood and adulthood. Each individual trauma was associated independently with either marijuana or cocaine use in adolescence, emerging adulthood and/or adulthood.ConclusionsChildhood trauma is prevalent in the United States, and individual types as well as the total number experienced are associated significantly with marijuana and cocaine use throughout the life‐course.
Novel navigation technique for the endodontic treatment of a molar with pulp canal calcification and apical pathology
Authors: Shi Xilin , Zhao Shiyong , Wang Weidong , Jiang Qianzhou , Yang Xuechao 
Published: June 2017

AbstractApical periodontitis, the inflammation of periapical tissue, commonly requires root canal treatment to achieve apical healing. However, if it is accompanied by pulp canal calcification, the treatment becomes complicated, and locating the root canal can be challenging. This case report describes a novel approach for treating a molar with pulp canal calcification and apical pathology. Due to the risk of perforation during treatment, a digitally printed template was used to assist in accurately locating the root canal. After six months, the patient was asymptomatic and the periradicular radiolucency was gradually reducing in size.
Anatomical Evaluation of the Thoracolumbar Nerves Related to the Transversus Abdominis Plane Block Technique in the Dog
Authors: Castañeda‐Herrera F. E. , Buriticá‐Gaviria E. F. , Echeverry‐Bonilla D. F. 
Published: June 2017

SummaryTransversus abdominis plane (TAP) is a fascial plane containing the thoracolumbar nerve branches that innervate the abdominal wall. Limited information is available on the anatomical organization of these nerve branches in the dog, which is of great importance for the success of the TAP block anaesthetic technique. The aim of this study was to describe the origin and conformation of thoracolumbar nerves running through the TAP in 20 hemi‐abdominal walls of 10 adult mongrel dog cadavers with an average body weight of 12.6 kg (range: 9.6‐15.6). The abdominal walls were dissected from superficial to deep direction, the skin and both obliquus externus abdominis and obliquus internus abdominis muscles were dissected and reflected dorsally to expose the transversus abdominis muscle and the thoracolumbar nerve branches located in this plane. The anatomical features of ventral nerve branches were described. The thoracic nerve branches: T7–T12 and costoabdominalis; and the lumbar nerve branches: iliohypogastricus cranialis, iliohypogastricus caudalis, ilioinguinalis and cutaneus femoris lateralis were identified in all the cadavers. Anatomical variations related to the presence or absence within the TAP of the T7, T8 and T9 nerve branches were found. These variations should be taken into account when planning the TAP block technique in dogs.
Cytomegalovirus DNA is highly prevalent in the blood of patients with asthma and is associated with age and asthma traits
Authors: Kowalski M. L. , Wardzynska A. , Studzinska M. , Pawelczyk M. , Lesnikowski Z. J. , Paradowska E. 
Published: June 2017

AbstractCytomegalovirus (CMV) IgG antibodies have been associated with inflammaging and immunosenescence. We aimed to assess the presence of CMV DNA in the blood of adult and elderly patients with bronchial asthma to establish potential association of CMV DNAemia with asthma and asthma characteristics. Eighty‐five elderly asthmatics, 74 younger asthma patients, and 114 age‐matched controls were recruited. The CMV DNA was detected using commercial artus assay in 10.7% of asthma patients, but was negative in all control individuals. The secondary assay identified CMV DNA in 41.5% of asthmatics and 13.3% of control subjects (P < .001). Presence of CMV DNA was associated with an increased risk of asthma and CMV DNA copy numbers correlated with some asthma traits, including respiratory parameters and exhaled breath nitric oxide. We conclude that CMV infection is associated with asthma and may contribute to the pathogenesis of asthmatic inflammation.
A Review of Hemolysis Prediction Models for Computational Fluid Dynamics
Authors: Yu Hai , Engel Sebastian , Janiga Gábor , Thévenin Dominique 
Published: June 2017

AbstractFlow‐induced hemolysis is a crucial issue for many biomedical applications; in particular, it is an essential issue for the development of blood‐transporting devices such as left ventricular assist devices, and other types of blood pumps. In order to estimate red blood cell (RBC) damage in blood flows, many models have been proposed in the past. Most models have been validated by their respective authors. However, the accuracy and the validity range of these models remains unclear. In this work, the most established hemolysis models compatible with computational fluid dynamics of full‐scale devices are described and assessed by comparing two selected reference experiments: a simple rheometric flow and a more complex hemodialytic flow through a needle. The quantitative comparisons show very large deviations concerning hemolysis predictions, depending on the model and model parameter. In light of the current results, two simple power‐law models deliver the best compromise between computational efficiency and obtained accuracy. Finally, hemolysis has been computed in an axial blood pump. The reconstructed geometry of a HeartMate II shows that hemolysis occurs mainly at the tip and leading edge of the rotor blades, as well as at the leading edge of the diffusor vanes.
Development of clinical paroxysmal nocturnal haemoglobinuria in children with aplastic anaemia
Authors: Narita Atsushi , Muramatsu Hideki , Okuno Yusuke , Sekiya Yuko , Suzuki Kyogo , Hamada Motoharu , Kataoka Shinsuke , Ichikawa Daisuke , Taniguchi Rieko , Murakami Norihiro , Kojima Daiei , Nishikawa Eri , Kawashima Nozomu , Nishio Nobuhiro , Hama Asahito , Takahashi Yoshiyuki , Kojima Seiji 
Published: June 2017

SummaryThe clinical significance of paroxysmal nocturnal haemoglobinuria (PNH) in children with aplastic anaemia (AA) remains unclear. We retrospectively studied 57 children with AA between 1992 and 2010. During the follow‐up, five patients developed clinical PNH, in whom somatic PIGA mutations were detected by targeted sequencing. The 10‐year probability of clinical PNH development was 10·2% (95% confidence interval, 3·6–20·7%). Furthermore, the detection of minor PNH clones by flow cytometry at AA diagnosis was a risk factor for the subsequent development of clinical PNH. These patients with PNH clones at AA diagnosis should undergo periodic monitoring for potential clinical PNH development.
MUC1‐C is a target in lenalidomide resistant multiple myeloma
Authors: Yin Li , Tagde Ashujit , Gali Reddy , Tai Yu‐Tzu , Hideshima Teru , Anderson Kenneth , Avigan David , Kufe Donald 
Published: June 2017

SummaryLenalidomide (LEN) acts directly on multiple myeloma (MM) cells by inducing cereblon‐mediated degradation of interferon regulatory factor 4, Ikaros (IKZF)1 and IKZF3, transcription factors that are essential for MM cell survival. The mucin 1 (MUC1) C‐terminal transmembrane subunit (MUC1‐C) oncoprotein is aberrantly expressed by MM cells and protects against reactive oxygen species (ROS)‐mediated MM cell death. The present studies demonstrate that targeting MUC1‐C with GO‐203, a cell‐penetrating peptide inhibitor of MUC1‐C homodimerization, is more than additive with LEN in downregulating the WNT/β‐catenin pathway, suppressing MYC, and inducing late apoptosis/necrosis. We show that the GO‐203/LEN combination acts by synergistically increasing ROS and, in turn, suppressing β‐catenin. LEN resistance has been linked to activation of the WNT/β‐catenin→CD44 pathway. In this regard, our results further demonstrate that targeting MUC1‐C is effective against LEN‐resistant MM cells. Moreover, GO‐203 resensitized LEN‐resistant MM cells to LEN treatment in association with suppression of β‐catenin and CD44. Targeting MUC1‐C also resulted in downregulation of CD44 on the surface of primary MM cells. These findings, and the demonstration that expression of MUC1 and CD44 significantly correlate in microarrays from primary MM cells, provide support for combining GO‐203 with LEN in the treatment of MM and in LEN‐resistance.
Favourable outcomes of poor prognosis diffuse large B‐cell lymphoma patients treated with dose‐dense Rituximab, high‐dose Methotrexate and six cycles of CHOP‐14 compared to first‐line autologous transplantation
Authors: Strüßmann Tim , Fritsch Kristina , Baumgarten Axel , Fietz Thomas , Engelhardt Monika , Mertelsmann Roland , Ihorst Gabriele , Duyster Justus , Finke Jürgen , Marks Reinhard 
Published: June 2017

SummaryThe optimal therapeutic approach for young diffuse large B‐cell lymphoma (DLBCL) patients with high‐intermediate and high‐risk age‐adjusted international prognostic index (aaIPI) remains unknown. Hereby we report a 10‐year single‐centre study of 63 consecutively treated patients. To optimize outcome, two approaches were carried out: Cohort 1 patients received four cycles R‐CHOP‐21 (rituximab, cyclophosphamide, daunorubicin, vincristine, prednisolone over 21 days) followed by first‐line high‐dose chemotherapy with autologous stem‐cell support (HDCT‐ASCT), resulting in 2‐year progression‐free (PFS) and overall survival (OS) of 60·6% and 67·9%. 39·4% of those patients were not transplanted upfront, mainly due to early progressive disease (24·2%). Cohort 2 patients received an early intensified protocol of six cycles of CHOP‐14 (cyclophosphamide, daunorubicin, vincristine, prednisolone over 14 days) with dose‐dense rituximab and high‐dose methotrexate resulting in promising overall response‐ (93·3%) and complete remission (90%) rates and sustained survival (2‐year PFS and OS: 93·3%). In an intention‐to‐treat analysis, 2‐year PFS (60·6% vs. 93·3%, hazard ratio [HR] 7·2, P = 0·009) and OS (69·7% vs. 93·3%, HR 4·95, P = 0·038) differed significantly, in favour of the early intensified protocol (Cohort 2). In a multivariate Cox‐regression model, PFS (HR 8·12, 95% confidence interval [CI] 1·83–35·9, P = 0·006) and OS (HR 5·86, 95% CI 1·28–26·8, P = 0·02) remained superior for Cohort 2 when adjusted for aaIPI3 as the most important prognostic factor. Survival of young poor‐prognosis DLBCL patients appears superior after early therapy intensification.
Cell‐of‐origin classification by gene expression and MYC‐rearrangements in diffuse large B‐cell lymphoma of children and adolescents
Authors: Szczepanowski Monika , Lange Jonas , Kohler Christian W. , Masque‐Soler Neus , Zimmermann Martin , Aukema Sietse M. , Altenbuchinger Michael , Rehberg Thorsten , Mahn Friederike , Siebert Reiner , Spang Rainer , Burkhardt Birgit , Klapper Wolfram 
Published: June 2017

SummaryWe present the largest series of diffuse large B‐cell lymphoma (DLBCL) in patients younger than 18 years analysed to date by gene expression profiling using Nanostring technology to identify molecular subtypes and fluorescent in situ hybridization for translocations of MYC. We show that the activated B cell‐like subtype of DLBCL is exceedingly rare in children and – in contrast to adults‐ not associated with outcome. Furthermore, we review the current literature and demonstrate that MYC translocations are not more frequent in paediatric compared to adult DLBCL. A prognostic role of MYC in the paediatric age groups seems unlikely.