bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supramolecular chemistry for the incorporation of multi‐guest molecules into two‐dimensional metal hydroxide hosts
Authors: Kim Taeho , Park Jin Kuen , Oh Jae‐Min 
Published: September 2024

AbstractThe incorporation of functional molecules into the interlayer space of layered double hydroxide (LDH) has been extensively studied for its role in immobilization, stabilization, manipulation of the molecular configuration, and the release from the host. To create dramatically enhanced properties and achieve unexpectedly high performances, it is necessary to incorporate multi‐guests as well as control the guest‐guest interaction. In the present review, we have summarized the multi‐guest incorporation into LDH based on the supramolecular chemistry, which provides insights into non‐covalent molecular interaction through host‐guest chemistry. Four well‐known intercalation methods in LDH, that is, coprecipitation, ion exchange, reconstruction, and exfoliation‐reassembly, are generally applied to multi‐guest intercalation. Combinative methods, in which two different intercalation approaches are combined, are also summarized. The multi‐guest incorporation, despite the difficulty involved in its synthesis design, could provide fine‐tuned and enhanced properties that are useful for a variety of applications.
Recent progress in visible light‐driven halogenation: Chlorination, bromination, and iodination
Authors: Nguyen Anh Thu , Kang Houng , Luu Truong Giang , Suh Sung‐Eun , Kim Hee‐Kwon 
Published: September 2024

AbstractHalogenation is one of the most important transformations in organic synthesis. Halogenated compounds are employed in many reactions to prepare useful molecules. Many methods have been developed to introduce halogens into different compounds. Visible light‐mediated reactions are the efficient, low‐toxic, and mild‐condition methods applied for various organic chemistry transformations. Remarkably, there has been an increasing development in the application of visible light‐induced halogenation in recent years. Herein, we present a comprehensive summary of halogenation reactions including chlorination, bromination, and iodination under visible light irradiation since 2020.
Do venture capital investments contribute to the achievement of the sustainable development goals?
Authors: Gucciardi Gianluca 
Published: September 2024

AbstractAchieving the goals of the 2030 agenda for sustainable development requires substantial investment and depends on the ability to attract private capital to complement public resources. Venture Capital (VC) investments have traditionally focused on sectors such as technology, healthcare, and clean energy, which align closely with the enhancement of sustainable development, and VC investors can accelerate progress toward sustainability by providing expertise and mentorship to startups working on sustainable solutions. This study aims to contribute to the literature on the intersection between finance and sustainability by investigating whether higher VC investments are associated with a higher level of achievement of the Sustainable Development Goals (SDGs). Using a panel data fixed effect model on a sample covering more than 100 countries, we find that a higher level of VC activity is associated with stronger SDGs' performances, with this effect being primarily driven by economic factors. We document heterogeneous effects related to the round of investments as well as the organizational form of VC investors and the industry and country of the VC‐backed companies.
Does corporate ESG, an essential factor for overcoming the climate crisis, affect sustainability: The effects of psychological distance and purchase intention
Authors: Lee Hyuck Jin 
Published: September 2024

AbstractThis study investigates the impact of Environmental, Social, and Governance (ESG) practices on consumer behavior, focusing on the role of psychological distance in shaping purchase intentions. Using construal level theory as the theoretical framework, primary survey data from South Korean consumers were analyzed. The findings reveal that social and governance activities within ESG positively influence consumers' psychological distance, enhancing purchase intentions. However, environmental activities do not show a similar effect. These results underscore the importance of clear and transparent communication regarding environmental efforts. This research expands the academic discourse on ESG by incorporating psychological distance and offers practical insights for businesses to develop effective ESG strategies tailored to consumer preferences.
Exploring the Antimicrobial Potential of Novel 1,2,4−Triazole Conjugates with Pyrazole: Synthesis, Biological Activity and In Silico Docking
Authors: Kolukula Ganesh Babu N. V. N. , Subramanyam Sibbala , Rao Allaka Tejeswara , Ahmed Mohammad Z. 
Published: September 2024

AbstractIn the present study, a new series of 1,2,4−triazole linked pyrazole hybrids (5 a–5 l) were synthesized from dimethyl amino pyrazole (1) in good yield by three‐step reaction. The chemical structures of the resulted compounds were thoroughly elucidated using spectral analyses such as IR, 1H‐NMR, 13C‐NMR, mass spectra and elemental analysis. The target compounds were screened for their antimicrobial activity against the various standard pathogenic Gram−(−ve) (E. coli, P. aeruginosa, K. pneumoniae, A. baumannii), and Gram−(+ve) (S. aureus, S. faecalis) microorganisms. According to the results obtained, in particular, compounds 5 b, 5 f, 5 h and 5 j was effective at inhibiting the antibacterial growth of all the bacteria's, having MIC values ranging 0.983–14.862 mg/mL and compared to moxifloxacin (1.391–22.01 mg mL−1). The most active compounds were chosen to interact with the DNA gyrase and topoisomerase‐IV targets via molecular docking. These selected ligands interacted with 2XCO, 1S16 targets and docked into the active site of amino acids Ala‐269, Gly‐413, Asn‐405, Ser‐1182, Thr‐1185, His‐1186, His‐1186, Lys‐1189, and Trp‐1213. Computational studies were carried out to design the precursor compounds to support the experimental part of the study. The pharmacokinetic properties, stability, and drug‐likeness parameters of all target molecules were estimated using SwissADME and PkCSM protocols. The current study used in silico approaches combining e‐pharmacophore modeling and structure‐based molecular docking of targets to identify antimicrobial agents.
New Phthalides and Isochromanone Derivatives from the Deep‐Sea‐Derived Fungus Penicillium bialowiezense A3
Authors: Lv Yinghui , Gong Linfeng , Zhang Gaiyun , Wu Jingna , Hong Bihong , Niu Siwen 
Published: September 2024

AbstractTwo new phthalide derivatives, namely bialowalides A (1) and B (8), and one new isochromanone analogue biourgalide C (11), together with 8 known phthalides (2–7, 9, and 10) as well as two known isochromanones (12 and 13) were discovered from the EtOAc extract of the deep‐sea‐derived fungus Penicillium bialowiezense A3. The structures were resolved on the basis of extensive spectroscopic analyses (NMR and HRESIMS data), in association with the modified Mosher's method and ECD data for the determination of the absolute configurations. All isolated secondary metabolites (1–13) were tested their antiviral activities against the SARS‐CoV‐2 trVLP pseudovirus at a concentration of 25 μM. As a result, compounds 1, 5, 11, and 12 exhibited the inhibitory effects against the luminescence at 46.2 %, 39.6 %, 45.5 %, and 48.8 %, respectively.
First‐in‐human: Leaflet laceration with balloon mediated annihilation to prevent coronary obstruction with radiofrequency needle (LLAMACORN) for valve‐in‐valve transcatheter aortic valve replacement
Authors: Mew Christina , Dahiya Arun , Chong Adrian A. , Hayman Samual M. , Moore Peter T. , Harrop Danielle L. , Reyaldeen Reza , Cole Christopher M. W. , Ross Jordan D. W. , Roberts Shaun , Korver Kellee A. , Cox Stephen V. , Camuglia Anthony C. 
Published: September 2024

AbstractCoronary obstruction (CO) is a potential pitfall for transcatheter aortic valve replacement (TAVR), especially in valve in valve procedures into degenerated surgical or transcatheter prostheses. Bioprosthetic leaflet modification techniques that incorporate electrosurgery are evolving as the preferred strategy to mitigate the risk of CO in high CO risk settings. The UNICORN method is proposed as a more predictable leaflet modification strategy than the earlier described BASILICA approach, but its proponents have hitherto mandated the use of a balloon‐expandable valve (BEV) prosthesis. Many patients have small prostheses and therein face a significant risk of patient prosthesis mismatch with BEV in this setting. This risk may be curtailed if a self‐expanding valve (SEV) prosthesis could be used. Herein described is a modified approach to allow for the utilization of SEV systems in this setting.
Practices and outcomes of rotational atherectomy in China: The Rota China registry
Authors: Wang Xiao , Zhang Hong , Bai Xiaojun , Zhang Li , Li Chengxiang , Mao Xiaobo , Chen Jue , Luo Jianfang , Zhao Yan , Zhou Binquan , You Bei'an , Zhang Yuelan , Ma Likun , Du Zhimin , Chen Yan , Sun Fucheng , Qiu Chunguang , Shen Zhujun , Wen Shangyu , Mintz Gary S. , Ye Fei , Nie Shaoping ,   China Rota Elite Group
Published: September 2024

AbstractBackgroundRotational atherectomy (RA) remains an integral tool for the treatment of severe coronary calcified lesions despite emergence of newer techniques. We aimed to evaluate the contemporary clinical practices and outcomes of RA in China.MethodsThe Rota China Registry (NCT03806621) was an investigator‐initiated, prospective, multicenter registry based on China Rota Elite Group. Consecutive patients treated with RA were recruited. A pre‐designed, standardized protocol was recommended for the RA procedure. The primary safety endpoint was major adverse cardiovascular events (MACE: composite of cardiac death, myocardial infarction, or ischemia‐driven target lesion revascularization) at 30 days. The primary efficacy endpoint was procedural success.ResultsBetween July 2018 and December 2020, 980 patients were enrolled at 19 sites in China. Mean patient age was 68.4 years, and 61.4% were men. Radial access was used in 79.1% patients, and 32.7% procedures were guided by intravascular imaging. A total of 22.6% procedures used more than 1 burr, and the maximal burr size was ≥1.75 mm in 24.4% cases, with burr upsizing in 19.3% cases, achieving a final burr‐to‐artery ratio of 0.52. Procedural success was achieved in 91.1% of patients, and the rate of 30‐day and 1‐year MACE was 4.9% and 8.2%, respectively. Multivariable analysis identified the total lesion length (HR 1.014, 95% CI: 1.002–1.027; p = 0.021) as predictor of 30‐day MACE, and renal insufficiency (HR 1.916, 95% CI: 1.073–3.420; p = 0.028) as predictor of 1‐year MACE.ConclusionsIn this contemporary prospective registry in China, the use of RA was effective in achieving high procedural success rate with good short‐ and long‐term outcomes in patients with severely calcified lesions.
Synthesis of Axially and Centrally Chiral N‐Alkenyl Indoles by Asymmetric Rh‐Catalyzed [2 + 2 + 2] Cycloaddition
Authors: Zhang Xuan , Teng Qi , Tung Chen‐Ho , Xu Zhenghu 
Published: September 2024

AbstractAxially chiral indoline‐based scaffolds are virtually universal in biological and pharmaceutical compounds. In this study, we demonstrate the Rh‐catalyzed asymmetric [2 + 2 + 2] cycloaddition of 1,6‐enynes with steric hindered N‐alkynyl indoles, which enables simultaneous construction of both axial and central chirality, containing a quaternary carbon center, in one step. Notable features of these reactions include excellent chemo‐, regio‐, diastereo‐ and enantioselectivity, 100% atom‐economy, easily available SEGPHOS ligand, and mild conditions.
Unraveling Molecular Diffusion Behaviors on the Acidic Sites of H‐ZSM‐5 Zeolite Using Time‐Resolved In Situ FT‐IR Technique
Authors: Liu Xiaoliang , Wang Yu , Teng Jiawei , Wang Yangdong , Xie Zaiku 
Published: September 2024

AbstractZeolites, renowned for their abundant crystalline structures and moderate acidities, have garnered significant attention in industrial chemical processes. Among them, the diffusion behaviors of various hydrocarbons within zeolite play a pivotal role due to their profound impact on product selectivity and separation efficiency. While acid sites are essential in determining the catalytic performance of zeolites, their effect on intra‐crystalline diffusivities has often been neglected in catalyst design. Herein, we employ a homemade time‐resolved in situ Fourier Transform Infrared (TR in situ FT‐IR) spectroscopy to investigate the intricate interplay between Brønsted acid sites and various probe molecules. Our study reveals that an augmentation in the density of Brønsted acid sites within H‐ZSM‐5 zeolites remarkably enhances the diffusivity of 1‐butene, in stark contrast to the behavior observed for iso‐butane. This contrasting effect in diffusivity is attributed to the distinct nature of interactions between alkenes and alkanes with Brønsted acid sites. Specifically, the π‐H interactions between alkenes and acid sites act as a driving force, propelling the alkene molecules forward through the zeolite pores. These findings offer valuable insights into designing tailored zeolites with specific acid site properties, controlling the transport behaviors of various probe molecules, and promising new avenues for catalysis and separation.
Manipulating the Substituent Sphere of a Bicyclic Silicon(I) Ring Compound Results in Anionic Cubane‐Type Clusters and a Tetrahedral Silanide
Authors: Quest Michael , Hepp Alexander , Hebenbrock Marian , Daniliuc Constantin G. , Bresien Jonas , Lips Felicitas 
Published: September 2024

AbstractThe reaction of the bicyclic silicon(I) ring compound Si4{N(SiMe3)Mes}4 1 with strong zwitterionic character and moderate sterical demand of the amido substituents with two equivalents of KC8 was investigated. This resulted in the unexpected abstraction of two amido substituents from 1 and additionally in dimerization to a dianionic Si8 cluster compound 2 with four unsubstituted silicon atoms and two [K([18]crown‐6)]+ counter cations. Performing this reaction in the absence of [18]crown‐6 results in release of only one amido substituent from 1 and dimerization to a dianionic Si8 cluster 3 with only two unsubstituted silicon atoms. This reaction with KC8 was repeated and trapping agents such as SiMe3Cl and tBuCl were added in‐situ whereupon the second isolated homocyclic silylene 4 and a monoanionic hydride and tBu substituted Si8 cluster 5 with one unsubstituted silicon atom were isolated. Furthermore, 1 was reacted with KOtBu which resulted in the selective abstraction of one SiMe3 group and formation of the tetrahedral silanide 6 with one imido substituent bridging an edge of the tetrahedron.
Harnessing Gene Editing Technology for Tumor Microenvironment Modulation: An Emerging Anticancer Strategy
Authors: Feng Shujun , Zhang Yu , Wang Yanyi , Gao Yanfeng , Song Yujun 
Published: September 2024

AbstractCancer is a multifaceted disease influenced by both intrinsic cellular traits and extrinsic factors, with the tumor microenvironment (TME) being crucial for cancer progression. To satisfy their high proliferation and aggressiveness, cancer cells always plunder large amounts of nutrients and release various signals to their surroundings, forming a dynamic TME with special metabolic, immune, microbial and physical characteristics. Due to the neglect of interactions between tumor cells and the TME, traditional cancer therapies often struggle with challenges such as drug resistance, low efficacy, and recurrence. Importantly, the development of gene editing technologies, particularly the CRISPR‐Cas system, offers promising new strategies for cancer treatment. Combined with nanomaterial strategies, CRISPR‐Cas technology exhibits precision, affordability, and user‐friendliness with reduced side effects, which holds great promise for profoundly altering the TME at the genetic level, potentially leading to lasting anticancer outcomes. This review will delve into how CRISPR‐Cas can be leveraged to manipulate the TME, examining its potential as a transformative anticancer therapy.
Decarboxylative Alkylation of Carboxylic Acids with Easily Oxidizable Functional Groups Catalyzed by an Imidazole‐Coordinated Fe3 Cluster under Visible Light Irradiation
Authors: Tamaki Sota , Kusamoto Tetsuro , Tsurugi Hayato 
Published: September 2024

AbstractDecarboxylative alkylation of carboxylic acids with easily oxidizable functional groups such as phenol and indole functionalities was achieved using a catalytic amount of basic iron(III) acetate, Fe(OAc)2(OH), in the presence of benzimidazole under 427 nm LED irradiation. Kinetic analyses of this catalytic reaction revealed that the reaction rate is first‐order in alkenes and is linearly correlated with the light intensity; the faster reaction rate for the benzimidazole‐ligated species was consistent with the increased absorbance in the visible light region. Wide functional group tolerance for the easily oxidizable groups is ascribed to the weak oxidation ability of the in situ‐generated oxo‐bridged iron clusters compared with other iron(III) species.
A Strongly Ambiphilic Ferrocene‐Based Cyclic (Alkyl)(amino)carbene – Specific Decomposition to an Enamine by a 1,2‐Phenyl Shift
Authors: Volk Julia , Heinz Myron , Guthardt Robin , Yadav Suman , Bruhn Clemens , Holthausen Max C. , Siemeling Ulrich 
Published: September 2024

AbstractThe recently described crystalline cyclic (alkyl)(amino)carbene with a 1,1’‐ferrocenylene (fc) backbone fc(CPh2−C−NMes) (A, Mes=mesityl) is highly reactive due to its particularly pronounced ambiphilicity and is thermally not stable in solution due to an intramolecular insertion of the divalent carbon atom into a methyl C−H bond of the Mes substituent. The closely related congener fc(CPh2−C−N‐p‐C6H4‐tBu) (1) cannot undergo such an insertion reaction. Nevertheless, 1 is too short‐lived for isolation due to a rapid 1,2‐shift of a phenyl group, furnishing the isomeric cyclic enamine fc[C(Ph)=C(Ph)−N‐p‐C6H4‐tBu] (1’) in a specific decomposition process unprecedented for CAACs. Trapping of 1 was possible with carbon monoxide, elemental selenium and with [CuBr(SMe2)], respectively affording the aminoketene 1=C=O, the selenoamide 1=Se and the homoleptic CuI complex [Cu(1)2][CuBr2]. 1 is an even stronger ambiphile than A according to NMR spectroscopic data. Similar to A, 1 does not react with H2, because the experimentally observed intramolecular process is kinetically more favourable according to DFT results.
Management of Sorghum Aphids in Early and Late‐Planted Grain Sorghum With an In‐Furrow Insecticide Application
Authors: Uyi Osariyekemwen , Toews Michael D. 
Published: September 2024

AbstractThe sorghum aphid (Melanaphis sorghi), also known as the sugarcane aphid, has become a significant pest in the southern United States since its detection in Texas and Louisiana in 2013, now affecting 25 states and impacting sorghum yields. Management strategies, such as resistant cultivars and insecticide applications, are employed, but further research is needed to optimize these methods and evaluate the combined effects of insecticide application and planting dates on aphid control and sorghum yield. The objective of this study was to evaluate the impact of insecticide applications and planting dates on M. sorghi infestations and grain sorghum yield over three growing seasons in Tifton, GA. Earn 1.0 CEU in Integrated Pest Management by taking the quiz for the article at https://web.sciencesocieties.org/Learning‐Center/Courses.
Transition Metal‐Nitrogen‐Carbon Single‐Atom Catalysts Enhanced CO2 Electroreduction Reaction: A Review
Authors: Ji Youan , Du Juan , Chen Aibing , Gao Xueqing , Peng Mengke 
Published: September 2024

AbstractAs the global energy crisis and environmental challenges worsen, CO2 conversion has emerged as a focal point in international research. CO2 electroreduction reaction (CO2ER) is a green and sustainable technology that converts CO2 into high‐value chemicals, thereby achieving the recycling of carbon resources. However, the activity and selectivity are constrained by the performance of the catalyst. Although traditional N‐doped carbon‐based catalysts exhibit excellent performance toward CO2ER, the atomic utilization rate in these materials is far from 100 %. Single atom catalysts (SACs) can attain nearly 100 % atomic utilization efficiency because of the fully exposing metal atoms. Therefore, SACs have emerged as one of the hot research materials in the field of CO2ER. Recently, transition metal‐nitrogen‐carbon single‐atom catalysts (TM−N−C SACs) have flourished because of their extraordinary catalytic activity, low cost, and excellent stability, demonstrating enormous application prospects in CO2ER. In this review, we concentrate on TM−N−C SACs that electrochemically reduce CO2 to high value products. A comprehensive and detailed discussion were conducted on the synthesis method, chemical structure, chemical characterization of TM−N−C SACs, as well as their catalytic performance, active sources, and mechanism exploration for CO2ER. Finally, challenges and prospects for commercial application of TM−N−C SACs catalysts suitable for CO2ER are proposed.
Research on key circuits of high‐precision servo channel loading card for wing fatigue testing
Authors: Zhao Baoshui , Xiao Yancai , Shen Haikuo , Zhi Shaodan 
Published: September 2024

AbstractThe key circuits of servo channel loading card with high‐precision data acquisition and output functions for wing fatigue testing are studied and improved in this paper. To solve the problem of large offset voltage in some op‐amps, non‐inverting combined amplifier circuit (NCAC) and inverting combination amplifier circuit (ICAC) are proposed by utilizing precision op‐amps combined with wide voltage and high‐power output op‐amps. In the force signal acquisition section, a non‐inverting combined zeroing filter circuit (NCZFC) is proposed to improve the precision of signal acquisition. In the excitation source output section, a non‐inverting combined excitation output circuit (NCEOC) is proposed to improve the precision of the positive excitation output; an inverting combined excitation output circuit (ICEOC) is also proposed, which improves the precision of the negative excitation output and also realizes the inversion of the input and output signals. In the servo drive output section, a non‐inverting combined voltage and current conversion circuit is proposed to improve the precision of voltage and current outputs, which has two modes of non‐inverting combined voltage output (NCVO) and non‐inverting combined current output (NCIO) modes. Simulation experiments in Multisim and actual tests have been carried out on the above improved circuits to verify the stability and precision.