bluuebunny/crossref_metadata_2025_split huggingface dataset:
De l’onanisme moral, ou la médecine des Lumières face à la fureur de lire
Authors: Vot Valérie Le 
Published: August 2017

Leselust (soif de lecture), Lesesucht (manie de lecture), Lesewut (fureur de lire) : les discours sur la prétendue « révolution de la lecture » qui prend place dans la seconde moitié du XVIIIe siècle dans les territoires allemands empruntent beaucoup au lexique médical. Par ce recours, le discours sur la lecture, volontiers imprécatoire et émotionnel, se pare d’objectivité scientifique et souligne la gravité de la situation, comparée à une épidémie (Leseseuche) qui réclame une réponse thérapeutique rapide et radicale. C’est dans le discours des médecins qu’on trouvera les réflexions les plus avancées sur les mécanismes de l’imagination, excitée par la lecture et rendue responsable de tous les maux, ainsi que les protocoles thérapeutiques les plus précis. Les écrits du médecin sans doute le plus influent des Lumières allemandes, Christoph Wilhelm Hufeland (1762-1836), se trouvent donc au cœur de l’analyse
Long-term Patterns of Patient Portal Use for Pediatric Patients at an Academic Medical Center
Authors: Cronin Robert M. , Davis Sharon E. , Yan Ellen , Jackson Gretchen P. , Steitz Bryan D. 
Published: August 2017

Summary
Background: Patient portal adoption has increased over the last two decades. Most research about patient portals has focused on adult populations in the primary care and medical specialty settings.
Objective: We describe initial and long-term portal use by pediatric patients and their caregivers in a broadly deployed patient portal at an academic medical center.
Methods: We analyzed portal usage for pediatric patients and their caregivers from 2008 to 2014. We recorded usage events with time stamps; user role defined as self, surrogate (i.e., parent or guardian), or delegate; and functions accessed. Usage events were grouped into sessions to calculate descriptive statistics by patient age, user role, and active use over time.
Results: From 2008 to 2014, the number of portal accounts increased from 633 to 17,128. 15.9% of pediatric patients had their own account; 93.6%, a surrogate account; and 2.2% a delegate account. During the study period, 15,711 unique users initiated 493,753 sessions and accessed 1,491,237 functions. Most commonly used functions were secure messaging (accessed in 309,204 sessions; 62.6%); test results (174,239; 35.3%) and appointments (104,830; 21.2%). Function usage was greatest for patients ages 0-2 years (136,245 functions accessed; 23.1%) and 15-17 years (109,241;18.5%). Surrogate users conducted 83.2% of logins for adolescent patients. Portal accounts were actively used for < 1 year for 9,551 patients (55.8%), 1-2 years for 2,826 patients (16.5%), 2–3 years for 1,968 patients (11.5%) and over 3 years for 2,783 patients (16.3%).
Conclusion: Pediatric patients and caregivers have avidly used messaging, test result, and appointment functions. The majority of access was done by surrogates. Adolescent portal usage increased with age. Most accounts for pediatric patients were only used actively for a few years, with peak usage for patients in early childhood and late adolescence.Citation: Steitz BD, Cronin RM, Davis SE, Yan Z, Jackson GP. Long-term Patterns of Patient Portal Use for Pediatric Patients at an Academic Medical Center. Appl Clin Inform 2017; 8: 779–793 https://doi.org/10.4338/ACI-2017-01-RA-0005
Comparison of BiliCare Transcutaneous Bilirubinometer with Standard Laboratory Assay
Authors: Warade Jayesh 
Published: August 2017

ABSTRACT

Introduction
Jaundice is the visible manifestation of chemical bilirubinemia and is characterized by yellow discoloration of skin. In a pediatric emergency department, evaluation of jaundice includes a precise medical history, physical examination, and estimation of bilirubin by laboratory tests. Measurement of total serum bilirubin (TSB) by transcutaneous bilirubin (TcB) is interpreted according to the age (in hours) of the newborn infant. Studies have also indicated that the TcB determination is more accurate than visual estimation methods.

Aim
To compare BiliCare System against standard laboratory testing for bilirubin estimation.

Results
The coefficient of correlation was r = 0.7245, and the standard deviation between the mean values of TcB and TSB is ±0.55.

Conclusion
It is concluded from the study that there is good correlation between TcB measurement and laboratory estimation of total bilirubin levels. It is recommended that transcutaneous measurement can be used for initial screening of jaundice as well as monitoring of phototherapy in neonates.

How to cite this article
Warade J. Comparison of BiliCare Transcutaneous Bilirubinometer with Standard Laboratory Assay. Indian J Med Biochem 2017;21(1):1-4.
Immune Response Profiling of Patients with Anogenital Warts
Authors: Singh Manjula , Thakral Deepshi , Kar Hemanta K , Rishi Narayan , Mitra Dipendra K 
Published: August 2017

ABSTRACTThe incidence of anogenital warts, commonly caused by human papillomavirus (HPV-6 and HPV-11), is increasing worldwide. These infections are frequently associated with relapse, possibly due to weak host immunity. However, the role of cell-mediated immune players in combating infection is not clearly understood till date. Here, we attempted to understand the immune profile among patients with anogenital warts. In this study, we compared the T-helper cell (Th1 and Th2) response in patients with venereal warts due to HPV-6 and HPV-11 infection relative to healthy controls (HCs)in vitro. In thein vitromodel, the peripheral blood mononuclear cells were stimulated with HPV peptide 6 or 11, stained for T-cell surface marker and intracellular cytokines (interferon [IFN]-□ and interleukin [IL]-4), and were analyzed by flow cytometry. In the present study, significant decrease was observed in the frequency of IFN-□ T cells as compared with HCs. On the contrary, frequency of T cells expressing IL-4 was significantly increased in the patients. The observed functional skewing of HPV-specific T cells from Th1 to Th2 response in patients indicated suppressed immunity against the HPVs. Findings of our study have potential in the near future for strategizing adjunct immunomodulation approaches with the standard treatment for early remission and prevention of recurrence.How to cite this articleSingh M, Thakral D, Kar HK, Rishi N, Mitra DK. Immune Response Profiling of Patients with Anogenital Warts. Indian J Med Biochem 2017;21(1):11-16.
Establishment of Reference Intervals of Serum Hepatic Enzymes in Tertiary Care Hospital: A Pilot Study
Authors: Rai P Shruthi , Shetty Sukanya , Patil Priya , Bhandary Roopa 
Published: August 2017

ABSTRACT

Introduction
Reference intervals are the most common decision-making tools for the interpretation of various biochemical reports. Age, sex, ethnicity, diet, physical, and socioeconomic conditions affect the physiology of population. Hence, it is necessary to set up the reference values that are applicable to a specific population rather than using the reference values established for other population-based studies or from the literature provided by the reagent kit manufacturers.

Aims and objectives
To establish the reference intervals of serum hepatic enzymes in tertiary care hospital.

Materials and methods
Hospital-based cross-sectional study was done involving 200 subjects. The subjects were randomly selected from the population, which included medical students, health professionals, and those attending different outpatient departments and health camps organized by the hospital for general checkups under health plan scheme. Serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) were estimated by the International Federation of Clinical Chemistry-recommended kinetic method and GGT by enzymatic colorimetric method. To obtain reference interval, 97.5th percentile and 2.5th percentile were used.

Results
The results for serum AST and GGT were found to be statistically significant. Hence separate reference intervals for both male and female were set up. Generalized reference intervals were established for serum ALT and ALP levels.

Conclusion
The present study revealed a significant difference in the reference intervals between males and females.

How to cite this article
Rai PS, Shetty S, Patil P, Bhandary R. Establishment of Reference Intervals of Serum Hepatic Enzymes in Tertiary Care Hospital: A Pilot Study. Indian J Med Biochem 2017;21(1):22-24.
Does Prolonged Storage of Serum Samples alter the Lab Results?
Authors: Tayal Devika , Gupta Mrinal 
Published: August 2017

ABSTRACT

Background
Sample storage for prolonged periods can lead to alterations in routine biochemical parameters.

Aim
This study was undertaken to observe the biochemical changes on serum samples when they are stored for prolonged periods at –20°C on different routine biochemical parameters.

Results
Significant changes were observed in serum glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, and potassium levels after 72 hours of storage, which further deteriorate in 3 months. Rest of the parameters did not show any significant alteration.

Conclusion
Prolonged storage of samples lead to alterations in the analyte concentration in serum. Serum glucose, AST, ALT, creatinine, and potassium levels should be estimated within 72 hours if prolonged storage is unavoidable. In conclusion, all the parameters should be assayed within 24 hours to avoid misinterpretation of results and better patient care.

How to cite this article
Tayal D, Gupta M, Goswami B. Does Prolonged Storage of Serum Samples alter the Lab Results? Indian J Med Biochem 2017;21(1):30-33.
Status and Effect of Vitamin D on Microvascular Complication in Type II Diabetes Mellitus Patients
Authors: Kishore P Krushna , Choudhary Ipsita 
Published: August 2017

ABSTRACT

Introduction
Vitamin D has a great impact on human health and disease. Recent studies proved that hypovitaminosis D is a possible risk factor for the pathogenesis of diabetes and its complications. In the present study, we evaluated vitamin D levels and its correlation with the duration of diabetes, sex, glycosylated hemoglobin (HbA1C), and microvascular complications in type II diabetes mellitus (T2DM) patients with and without microvascular complications.

Objectives
To study and correlate vitamin D levels and its relation with duration of diabetes, sex, glycemic control, and microvascular complication in T2DM patients with and without microvascular complications.

Materials and methods
Cross-sectional case–control study of 200 patients (35–70 years) suffering from T2DM was included. The T2DM patients without microvascular complications served as control group. Enrolled subjects underwent complete physical examination to detect the presence of microvascular complications, which includes microfilament tests, detailed fundus examination, urinary microalbumin/creatinine ratio. Fasting blood sugar, HbA1C, and serum vitamin D were also measured by using serum sample.

Results
Prevalence of vitamin D deficiency and insufficiency was found to be significantly higher in T2DM patients with microvascular complications (19.54 ± 2.56 vs 28.57 ± 2.93) as compared with T2DM patients without microvascular complications (p < 0.001). Hypovitaminosis D was found to be significantly more in females (60.75%) compared with males (39.96%) in both the study groups (p < 0.0001). Hypovitaminosis D was correlated with glycemic control and prevalence of microvascular complications.

Conclusion
Vitamin D is correlated with glycemic status and sex difference and has a role in pathogenesis of T2DM and its complications.

How to cite this article
Kishore PK, Choudhary I. Status and Effect of Vitamin D on Microvascular Complication in Type II Diabetes Mellitus Patients. Indian J Med Biochem 2017;21(1):34-37.
Novel Lipid Indices as a Better Marker of Cardiovascular Disease Risk in Postmenopausal Women
Authors: Sirigere Muruga , Meera S 
Published: August 2017

ABSTRACT

Introduction
Cardiovascular disease (CVD) is the major leading cause of mortality in men and women around the globe. The incidence of CVD increases with age in both the sexes, whereas it has been noted that there is a marked increase in risk among women after menopause. The hormonal changes associated with the menopause like low level of plasma estrogen and marked increase in follicle stimulating hormone levels exert a significant effect on metabolism of plasma lipids and lipoproteins leading to atherosclerosis, thereby increasing the risk of CVD in postmenopausal women.

Objectives
To study the lipid profile parameters and to calculate and compare the lipid indices with lipid profile parameters in pre- and postmenopausal women.

Materials and methods
The study group included 90 women comprising 45 postmenopausal (cases) and 45 premenopausal (control) women. To estimate lipid profile, enzymatic method was used and for calculation of lipid indices appropriate formula was used.

Results
Altered lipid profile was observed in postmenopausal women, but it was not statistically significant. Atherogenic Index of Plasma, Castelli's risk index-I, atherogenic coefficient, and nonhigh-density lipoprotein cholesterol were significantly increased in postmenopausal women compared with premenopausal women, but there was no significant increase in Castelli's risk index-II.

Conclusion
Lipid indices may be considered as a better and cost-effective tool in assessing the risk of CVD in postmenopausal women.

How to cite this article
Sirigere M, Meera S. Novel Lipid Indices as a Better Marker of Cardiovascular Disease Risk in Postmenopausal Women. Indian J Med Biochem 2017;21(1):38-41.
Case-based Learning in Biochemistry: An Innovative Criterion-based Assessment Module for Effective Learning among MBBS Phase 1 Students in India
Authors: Axita Vani C , Mudaraddi Rakesh T , Shetty Praveenkumar , Shilpasree AS 
Published: August 2017

ABSTRACTIntroductionThe main focus of case-based learning (CBL) is to integrate basic science material with clinical science. Case-based learning may be designed and introduced along with traditional didactic lectures in a way that it creates interest, promotes better understanding, active participation, and self-directed learning. The student should be motivated to become a life-long learner.InterventionWe have formulated an innovative criterion-based module for implementation and evaluation of MBBS phase 1 students. This includes framing of a time schedule for distribution of teaching hours based on multiple teaching tools and module for conducting CBL sessions. This will be assessed by evaluation of student performance using a newly developed valid assessment tool.Materials and methodsFor the CBL sessions, 100 students of phase 1 MBBS course were included. They were divided into 10 groups of 10 students each. Ten clinical cases were selected for CBL sessions. Each student was given two cases for discussion. Pretest was conducted before and posttest after the CBL session. The session was conducted as planned in the module. The performance of the students was analyzed. Feedback from the students and teachers were taken and analyzed for its utility and effectiveness.ResultsThe performance of the students showed drastic improvement after the CBL sessions (p < 0.0001); 85% of the students and 80% of the teachers agreed that CBL helps in deep learning and critical thinking; 84% of students and 73% teachers felt that CBL makes subject interesting with good retention of contents and reasoning ability for their future medical practice.ConclusionOur newly formulated assessment tool stands appropriate, which can be included in the present curriculum. Both the teachers and the students were satisfied with this kind of teaching method. This innovative teaching module and our newly formulated assessment tool proved to be very effective for learning biochemistry.How to cite this articlePatil VP, Patil VS, Kulkarni SP, Trivedi DJ, Axita VC, Mudaraddi RT, Shetty P, Bargale AB, Kamble PS, Ingleshwar DG, Shilpasree AS. Case-based Learning in Biochemistry: An Innovative Criterion-based Assessment Module for Effective Learning among MBBS Phase 1 Students in India. Indian J Med Biochem 2017;21(1):62-68.
Reading hypermedia narrative stars, 88 Constellations For Wittgenstein by David Clark. Analytical approach to Constellation 18 Cassiopeia
Authors: Meza Nohelia 
Published: August 2017

http://dx.doi.org/10.5007/1807-9288.2015v11n1p287Este artigo apresenta uma abordagem para analisar elementos de hipermídia encontrados no discurso de "Cassiopeia", uma das constelações que compõem 88 Constellations for Wittgenstein (To Be Played with the Left Hand) (2011), pelo artista [ ] David Clark. Embora existam muitas abordagens para o tema da literatura eletrônica, ainda há muitas obras inexploradas esperando para serem estudadas, o que, indubitavelmente, levantará questões sobre a literalidade da literatura eletrônica. Este artigo descreve brevemente as questões de representação, temporalidade, semióticas, interação e manipulação nesta constelação específica do trabalho acima mencionado. O artigo utiliza teorias literárias específicas do meio digital (possibilidades temporais em textos programados, níveis temporais para cibertextos com conteúdo narrativo, acoplamento pluricode, instabilidade de obras digitais) a fim de examinar as nuances e gradações da textualidade eletrônica e da recepção literária. A análise mostra que a manipulação e a interação do usuário com a obra afetam certos elementos do discurso narrativo hipermídial e sugere novas possibilidades de interpretação temporal e semiótica.
Estácio, "Aquileida", I.318-337, Apresentação e tradução
Authors: Estácio Públio Papínio , Moreira Daniel Da Silva 
Published: August 2017

http://dx.doi.org/10.5007/1980-4237.2014n16p184Este texto apresenta e contextualiza uma tradução versificada de uma importante passagem do primeiro livro da Aquileida (Achilleis), de Públio Papínio Estácio, poeta romano do século I d.C.ABSTRACTThis text presents and contextualizes a versified translation of an important passage from the first book of the Achilleid, by Publius Papinius Statius, a Roman poet from the first century a.D.Keywords: Statius; Achilleid; epic poetry; translation.
Translation of Cecília Meireles’ Elegia with Commentary
Authors: Meireles Cecília , Holloway Patrick 
Published: August 2017

http://dx.doi.org/10.5007/1980-4237.2014n16p195"Elegia" é um poema de Cecília Meireles carregado de sentimento. Já em sua dedicatória (À memória de Jacinta Garcia Benevides, Minha avó) fica claro que o leitor está a ponto de entrar uma terra de nostalgia e ‘saudades’ (palavra intraduzível). No poema, Meireles alia a tristeza e a dor pela perda de sua avó a sentimentos relacionados à natureza e à beleza, derivados das memórias com ela a partir das quais aprendeu a contemplar e amar todas as coisas. Esta tradução comentada espera revelar como o tradutor da "Elegia" conseguiu vertê-la para a língua inglesa e criar uma versão que, por um lado, se mantém de pé por si mesma na língua e cultura alvo, e, por outro, permite ao leitor ter o mesmo tato e sentimento em inglês pela poesia de Meireles como os têm os leitores em português.ABSTRACT"Elegia" is a poem written by Cecília Meireles laden with sentiment. From its dedication (In memory of Jacinta Garcia Benevides, my grandmother) it is clear that the reader is entering into a land of nostalgia and ‘saudades’ (an untranslatable word). In this poem Meireles allies the sadness and pain over the loss of her grandmother to feelings of nature and beauty derived from the memories with her grandmother in which she was taught to contemplate and love all things. This translation with commentary hopes to show how the translator of the poem was able to render Cecília Meirele’s "Elegia" into the English language and to create a translation that on one hand stands alone in the target language and culture and on the other allows the reader to get the same feel for Meirele’s poetry in English as they do in Portuguese.Keywords: Cecília Meireles; Elegy; poetry translation; translation with commentary.
Translating Homer / Traduzindo Homero
Authors: Johnson Samuel , Althoff Gustavo , Furlan Mauri 
Published: August 2017

Samuel Johnson (1709-1784), crítico, ensaísta, jornalista, poeta, educador e lexicógrafo, é considerado uma das personalidades mais proeminentes no mundo intelectual da Bretanha do século XVIII. Em 1777, ele recebeu a proposta de um grupo de livreiros para escreveruma série de vidas de poetas ingleses, e entre 1779-81 foi publicada a obra TheLives of the English Poets, a qual contém a vida de Alexander Pope (1688-1744),de onde extraímos o excerto abaixo. (Robinson, 2002). Samuel Johnson elogia o trabalho de Pope na tradução de Homero e a sua contribuição para a versificação em inglês. E observa que a tradução de Pope não é fiel e não tem a simplicidade do original. Johnson, contudo, justifica as variações apresentadas por Pope em sua tradução em razão da distância existente entre aslínguas, as épocas, os lugares.
Oyèrónké Oyĕwùmí, de uitvinding van ‘de vrouw’ en de grenzen van de (feministische) filosofie
Authors: Coetzee Azille 
Published: August 2017

Abstract

Oyèrónké Oyĕwùmí, the Invention of Women and the Limits of (Feminist) Philosophy

In this paper I argue that the work of Nigerian feminist scholar Oyèrónké Oyĕwùmí reveals the limitations of the attempts by Western feminist philosophers to subvert philosophy’s occupation with the universal. By paying close attention to the particularities of Yorùbá society, Oyĕwùmí creates a knowledge framework or epistemology that poses a profound challenge to Western feminist thought by undermining and disputing the universality of its foundational concepts. She illustrates how the concepts central to Western feminist thought, such as ‘woman’ and ‘gender’ are constructed on the basis of Western cultural particulars which are universalized at the expense of societies with alternative cultural and social configurations. Her work therefore reveals the way in which Western feminist thought, despite its attempts to produce knowledge that is situated and rooted in the particular, remains permeated with and reliant on Western concepts that it uncritically assumes to be universal. I place Oyĕwùmí in dialogue with Belgian feminist philosopher Luce Irigaray to illustrate this point in more concrete terms. I show that although Irigaray identifies and explains how philosophy works to silence and erase Others, and what must be done to overcome this, her focus on sexual difference leads her to step into the same trap as the philosophers she criticizes.
Kunnen moslims denken?
Authors: Leezenberg Michiel 
Published: August 2017

Abstract

Can Muslims Think? The Invisibility of the Islamic Philosophical Tradition

This paper discusses some authors and genres of the classcial Islamic tradition not generally recognized as philosophical, but relevant both for the understanding of today’s confrontation between the Islamic world and the liberal West, and for academic philosophical discussions of Islam. I focus on the theologian Ibn Taymiyya, who has been hijacked by modern salafi-jihadi activists, but who gives a critique of Aristotelian syllogistic that is philosophically serious and substantial, and on the classical Persian poetic tradition, which turns out to embody an ethical tradition of practical humanist wisdom. An awareness of the very existence of such traditions can help to combat the reductionist and ahistorical views of the Islamic world that pervade the contemporary public debate.