bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stage-specific expression patterns and co-targeting relationships among miRNAs in the developing mouse cerebral cortex
Authors: Todorov Hristo , Weißbach Stephan , Schlichtholz Laura , Mueller Hanna , Hartwich Dewi , Gerber Susanne , Winter Jennifer 
Published: October 2024

AbstractmicroRNAs are crucial regulators of brain development, however, miRNA regulatory networks are not sufficiently well characterized. By performing small RNA-seq of the mouse embryonic cortex at E14, E17, and P0 as well as in neural progenitor cells and neurons, here we detected clusters of miRNAs that were co-regulated at distinct developmental stages. miRNAs such as miR-92a/b acted as hubs during early, and miR-124 and miR-137 during late neurogenesis. Notably, validated targets of P0 hub miRNAs were enriched for downregulated genes related to stem cell proliferation, negative regulation of neuronal differentiation and RNA splicing, among others, suggesting that miRNAs are particularly important for modulating transcriptional programs of crucial factors that guide the switch to neuronal differentiation. As most genes contain binding sites for more than one miRNA, we furthermore constructed a co-targeting network where numerous miRNAs shared more targets than expected by chance. Using luciferase reporter assays, we demonstrated that simultaneous binding of miRNA pairs to neurodevelopmentally relevant genes exerted an enhanced transcriptional silencing effect compared to single miRNAs. Taken together, we provide a comprehensive resource of miRNA longitudinal expression changes during murine corticogenesis. Furthermore, we highlight several potential mechanisms through which miRNA regulatory networks can shape embryonic brain development.
Advanced three-dimensional X-ray imaging unravels structural development of the human thymus compartments
Authors: Savvidis Savvas , Ragazzini Roberta , de Rafael Valeria Conde , Hutchinson J. Ciaran , Massimi Lorenzo , Vittoria Fabio A. , Campinoti Sara , Partridge Tom , Ogunbiyi Olumide K. , Atzeni Alessia , Sebire Neil J. , De Coppi Paolo , Mittone Alberto , Bravin Alberto , Bonfanti Paola , Olivo Alessandro 
Published: October 2024

Abstract
Background
The thymus, responsible for T cell-mediated adaptive immune system, has a structural and functional complexity that is not yet fully understood. Until now, thymic anatomy has been studied using histological thin sections or confocal microscopy 3D reconstruction, necessarily for limited volumes.

Methods
We used Phase Contrast X-Ray Computed Tomography to address the lack of whole-organ volumetric information on the microarchitecture of its structural components. We scanned 15 human thymi (9 foetal and 6 postnatal) with synchrotron radiation, and repeated scans using a conventional laboratory x-ray system. We used histology, immunofluorescence and flow cytometry to validate the x-ray findings.

Results
Application to human thymi at pre- and post-natal stages allowed reliable tracking and quantification of the evolution of parameters such as size and distribution of Hassall’s Bodies and medulla-to-cortex ratio, whose changes reflect adaptation of thymic activity. We show that Hassall’s bodies can occupy 25% of the medulla volume, indicating they should be considered a third thymic compartment with possible implications on their role. Moreover, we demonstrate compatible results can be obtained with standard laboratory-based x-ray equipment, making this research tool accessible to a wider community.

Conclusions
Our study allows overcoming the resolution and/or volumetric limitations of existing approaches for the study of thymic disfunction in congenital and acquired disorders affecting the adaptive immune system.
Examining Factors That Contribute to Poststroke Depression Within the Family Caregiver and Care Recipient Dyadic Experience
Authors: Gurley Nettles Tiffany C. 
Published: October 2024

Purpose:
Stroke survivors often experience biochemical changes in the brain. This decreases the ability to experience positive emotions. Stroke survivors contend with the loss of their former self and are often left with residual physical, cognitive, communicative, and psychological changes leading to a depressive state. With an increasing number of stroke survivors returning to the community, informal care provided by family members will continue to rise. Many of the challenges faced by stroke survivors with poststroke depression (PSD) and by family caregivers (FCGs) have a significant impact on the relationship itself. With the goal to obtain insight into potential contributing factors to poststroke depressive features in stroke survivors, this qualitative research study aimed to investigate the experiences, behaviors, and perceptions of participants with PSD living in the dyadic relationship between FCG and stroke survivors.

Method:
Six FCG–stroke survivor care recipient dyads served as the participants. All stroke survivor care recipients were diagnosed with or had signs and symptoms of depression poststroke. Semistructured interviews were conducted with stroke survivors within each dyadic relationship. All participants were within this dyadic relationship for at least 3 months.

Results:
Six themes emerged from the stroke survivors. The findings indicated that grieving of the former self, lack of self-efficacy, isolation, difficulty with communication, perceived stress of the FCG, and lack of depressive coping skills are factors that contribute to PSD.

Conclusions:
There were multiple factors experienced by stroke survivors within the dyad affecting their emotional state and leading to or exacerbating depressive symptoms. Additionally, stroke survivors have limited coping strategies for depressive symptoms. Stroke survivor informational counseling, training, and education may improve coping strategies and decrease symptoms of depression and therefore lead to strengthened rehabilitative outcomes.

Supplemental Material:

https://doi.org/10.23641/asha.27156381
Unveiling the Landscape of Brazilian Clinical Oncologists: Challenges, Diversity, and Quality Care
Authors: Bezerra Sarah Mendes , Madi Marisa Riscalla , Chaves Aline Lauda Freitas , Melro-Braghiroli Maria Ignez Freitas , Hoff Paulo Marcelo Gehm , Ferreira Carlos Gil , Bonanno Lucas Pondaco , Leite Gustavo Andrade Pimenta 
Published: October 2024

AbstractCancer remains a significant public health challenge in Brazil, with an estimated 704 thousand new cases annually. Clinical oncology, a pivotal specialty in cancer diagnosis and treatment, has evolved since its formal establishment in 1946. Recent recognition by the Brazilian Federal Board of Medicine solidified its status, culminating in normative resolution nr. 2,162/2017. The present study aims to characterize Brazilian clinical oncologists and analyze their epidemiological and structural contexts using data from the Brazilian Society of Clinical Oncology's 2023 census and secondary sources, including the National Cancer Institute (Instituto Nacional de Câncer [INCA], in Portuguese) and Brazilian Institute of Geography and Statistics (Instituto Brasileiro de Geografia e Estatistica [IBGE], in Portuguese). A cross-sectional design employing qualitative-quantitative methods surveyed 761 clinical oncologists, revealing insights into demographics, workload, stress levels, and challenges. The results highlight regional disparities in cancer mortality rates despite the concentration of oncology services in the South and Southeast. Challenges include access to new treatments, late diagnoses, and systemic underfunding. Moreover, this study underscores gender and racial disparities within the specialty, indicating a predominantly white and heterosexual profile among practitioners. Addressing these issues is crucial for enhancing healthcare equity and improving patients' outcomes in oncology practice.
Recent trends in extratropical lows and their rainfall over Australia
Authors: Pepler Acacia 
Published: October 2024

Low pressure systems are an important source of rainfall in southern Australia, particularly deep lows that extend from the surface to at least 500 hPa. This paper uses multiple reanalyses to assess long-term trends in lows over the period 1959–2023, and identifies statistically significant decreasing trends in the number of surface low pressure systems near southern Australia during May–October, linked to a decrease in cyclogenesis near south-western Western Australia. Trends in lows at 500 hPa are also negative but weaker than at the surface, and are less consistent between reanalyses owing to less consistent observations through time. The spatial pattern of observed declines during the cool season is consistent with trends using eight CMIP6 models, but global climate models systematically underestimate the magnitude of the observed decline in surface lows. Trends in rainfall associated with lows are also shown, including assessing the sensitivity of trends to the specific years used. Despite well above average numbers of lows and enhanced rainfall during recent La Niña years 2020–2022, total rainfall from low pressure systems is declining during the cool season in south-east Australia. Trends in rainfall from lows are largest on the east coast, where they explain more than 70% of observed rainfall changes since the 1960s.
Testing the Phenomenological Interacting Dark Energy Model with Gamma-Ray Bursts and Pantheon+ type Ia Supernovae
Authors: Nong Xiao-Dong , Liang Nan 
Published: October 2024

Abstract
In this paper, we utilize recent observational data from gamma-ray bursts (GRBs) and Pantheon+ supernovae Ia (SNe Ia) samples to explore the interacting dark energy (IDE) model in a phenomenological scenario. Results from GRBs alone, SNe Ia and GRBs+SNe Ia indicate that the energy is transferred from dark energy to dark matter and the coincidence problem is alleviated. The value of H
0 from GRBs+SNe Ia in the IDE scenario shows agreement with the SH0ES measurement. Considering the age estimate of the quasar APM 08279+5255 at z = 3.91, we find that the phenomenological IDE scenario can predict a cosmic age greater than that of the ΛCDM model, thus the cosmic age problem can be alleviated.
Projection of Electric Ships as Sustainable Transportation in the Capital City of Indonesia “Nusantara”
Authors: Syahr Z.H.A. , Syaifullah D.H. , Hakim M.R. , Putra S.G.M.S.R. , Albana M.Z. , Hutapea T.P.D. , Tobing C.N.M. 
Published: October 2024

Abstract
Nusantara is Indonesia’s new capital or knows as Ibu Kota Nusantara (IKN) for implementing the sustainable city concept. Waters separate the area around IKN with a total area of 68,188 ha. Therefore, people living in IKN, namely in Penajam and its surroundings, have become accustomed to using water transportation to travel between regions. Ship transportation that the community has often used has also been developed with electric ships to support sustainable cities and zero emissions at IKN. However, in implementing electric ships, problems arise, namely how to project the development of electric ship technology based on policy documents and development planning in the Nusantara Capital City. The objective to be achieved is to see the planning and policy document for developing environmentally friendly water transportation using electric power. The method used in this study is qualitative, with a synthesis approach. Data collection was carried out by document study from policies and regulations. The data was then analyzed descriptively to obtain important information about the problem. For the result, the projection of the of electric ships in IKN must be carefully planned so that it can be realized to support Sustainable City and zero emission in IKN later.
Development of Small Modular Reactor iPWR Dynamics Simulator
Authors: Alfariji R , Nurhidayah S P , Bakhri S , Subekti M , Kiswanta  , Sudarno  , Saputra A 
Published: October 2024

Abstract
In the energy transition era, nuclear power serves as a significant source of electricity with low emissions, contributing to approximately 10% of the world’s total electricity production. The advanced and distinct features of iPWR-type SMR in the field of nuclear power generation contribute to a greater safety margin. This opens up possibilities for extending the utilization of secure, environmentally friendly, and dependable nuclear energy across various energy sectors. Moreover, the public need to understand the technical performance of the iPWR. To improve understanding of iPWR’s technical performance, a simulator is developed. The simulator is developed to provide a comprehensive study of nuclear reactor transient behavior, to serve as an educational tool for students, and to demonstrate the safety features during accident scenarios. This article introduces a simulator that combines modules of neutronics, reactor thermal-hydraulics, and the NSSS. The simulator uses the design parameters of iPWR with a power capacity of 160 MWt that relies on natural convection. The proposed simulator was developed using LabVIEW software to perform the reactor dynamics calculations. Furthermore, hardware devices for controlling the simulator can be integrated to simulate the control room of an NPP. The calculation was based on the standard lumped parameter point kinetics and thermal-hydraulic equations. To simplify the process and reduce computational cost, several assumptions are incorporated into the equations, including one-group thermal neutron and constant gain thermal power. The simulator development yields preliminary data for reactor calculations, the graphical user interface (GUI) of the simulator, and the Virtual Instruments (VIs) comprising the reactor model. The reactor model comprises multiple components, each represented as a subVI within the LabVIEW environment. This simulator serves as an effective educational and dissemination tool for increasing public acceptance of NPP by providing insights into the behavior of the reactor and facilitating a better understanding of its operation, safety features, and potential benefits.
Comparison of Microwave Adsorpsion of Core-Shell Fe3O4@SiO2by Different Methods
Authors: Yusmaniar  , Fuazi M. R. , Rahma Y. , Khairany I. W. , Hermawan F. R. 
Published: October 2024

AbstractIn this research, magnetite nanoparticles coated with sillica from rice husk ash (core-shell Fe3O4@SiO2) were synthesized by a modified stöber method through hydrolisis of silica using basic catalyst. Phase composition, morphology and microstructure were characterized using XRD, SEM, and TEM. The result shows that the sillica shell was successfully coated the core of nanoparticles magnetite. Core-shell Fe3O4@SiO2were synthesized using two method, first silica extraction and second through the silica gel. The application on microwave absorption are measured using VNA at the X-band frequency (8-12 GHz). Materials reach a reflection loss value of -34,29 dB at a frequency of 10,98 GHz for the first method (extraction of silica). For the second method (through silica gel), it exhibits two maximum absorptions with a reflection loss value under -20 dB, which are -23,05 dB at a frequency of 10,1 GHz and -25,03 dB at a frequency of 10,98 dB.
Sensitivity and accuracy of single-mode fiber optic sensor for non-invasive glucose measurement
Authors: Fridayanti Nola , Muldarisnur Mulda , Novirza Resti 
Published: October 2024

Abstract
Routine glucose level monitoring is essential for diabetic patients. Standard measurement methods based on finger pricking are inconvenient and susceptible to infection risk. Therefore, simple and non-invasive measurements are urgently needed. Compared to other approaches, glucose level measurement using optical methods offers many advantages, such as set-up simplicity, high sensitivity, and high accuracy. We optimize the sensing performance of glucose level sensors based on a single-mode fiber optic. The fiber optic serves as a medium for light propagation from a diode laser to a photodiode and, at the same time, serves as an active sensing medium. In the sensing area, the fiber optic cladding is partly (i.e., 1 – 5 cm) stripped to allow direct contact, which leads to evanescent wave absorption by glucose molecules. The length of fiber optic stripping and bending radius, which determine the sensitivity and accuracy of the sensor, varied. Bent fiber optic sensors consistently show a higher sensitivity and accuracy than straight ones. Maximum sensitivity of 2.35 mV/(mg/dL) was attained for a 3 cm stripping length and 4.5 cm bending radius. The lowest sensitivity of the sensor, 0.453 mV/(mg/dL), was acquired at the stripping length of 5 cm for the straight fiber optic sensor. The highest accuracy of the developed sensor is 99% for bent fiber optic sensors.
New 5-6-6-5 (fourfold) and 5-9-6 defect Configurations in g-SiC (graphene-like hexagonal monolayer silicon carbide)
Authors: Oktavina C W , Fajariah N , Fadlliyana M , Nugraheni A D , Sholihun  
Published: October 2024

Abstract
Computational studies using the density functional theory (DFT) were employed to analyze defect configurations in g-SiC. The SiC supercells containing 72 atoms were used for simulation. We simulate C-vacancy (VC) and Si-vacancy (VSi). We relaxed all atoms so that the atomic force tolerance is 1.0 × 10−4 Ha/Bohr. The unrelaxed defective configurations have the same symmetry as the perfect configuration, which is a D3h symmetry. During relaxation, atoms neighboring the vacancy were displaced to reach a ground state condition. In the case of VC, a Si atom at the center of the defect has four bonds, resulting in a new 5-6-6-5 fourfold configuration with a C2v symmetry. In the case of VSi, a C atom forms bonds with two other C atoms, resulting in a new configuration, namely a 5-9-6 configuration. We identified that this configuration also has a C2v symmetry. Thus, symmetry breaking (lowering) occurs from D3h to C2v. We calculated the formation energy, which is 3.28 eV for the 5-6-6-5 fourfold and 3.92 eV for the 5-9-6 configuration. We also calculated the Density of States (DOS), and the results show that both configurations have semiconductor material properties suitable for promising optoelectronic devices with an infrared spectrum for future applications.
Peatlands changes analysis in Banjar District using three decades of Landsat imagery
Authors: Nurlina  , Ridwan I , Muslimin S , Roup A 
Published: October 2024

Abstract
Peatlands are a multifunctional wetland ecosystem, so it is essential to know the changes in their presence. Observation of the changes in peatlands can be done in two ways, i.e., indirect and direct observation. Indirect observation can be done with remote sensing technology. This study aimed to analyze the distribution and peat land cover change from 1990 to 2020 and calculated the land’s rate changes. This research uses the maximum likelihood classification with seven classes of land cover input of agriculture, plantations, forests, bare lands, settlements, shrubs, and water bodies. The classification result covers a map of Banjar Regency peatlands covering 1990, 2000, 2009, and 2020, and then analyzes to know the land’s rate changes. The results of this research inform Banjar’s peatland area is 58,048.76 ha, which is spread over eight districts, i.e., Astambul, Beruntung Baru, Gambut, Martapura, Martapura Barat, Mataraman, Simpang Empat dan Sungai Tabuk. The land’s rate changes in 1990 and 2000; almost all of the land cover has the addition of wide each year, most of it is shrubs around 870.47 ha per year, only covering the reduction of forest land with an area of approximately 1,293.80 hectares per year. In 2000 to 2009 shows that four land covers experience and increase in area per year, namely settlements 11.71 ha, agriculture 30.69 ha, water bodies 6.76 ha and the largest oil palm plantation 1,098.5 ha. While those that experienced a reduction in area per year were bare land around 335.61 ha and shrubs around 812.11 ha. While the rate of change from 2009 to 2020 which experienced an increase in area each year was 15.19 ha of water bodies, 422,9 ha of bare land, 1,073.07 ha of oil palm plantations and around 1,508.2 ha of agriculture. While those that experienced a reduction in area per year were shrubs 3,184.2 ha, and settlement 32.76 ha. The data from these findings is crucial to the national wetlands inventory database for upcoming assessments, even though they offer valuable insights into using conservation measures in the context of wetland sustainability.
Photometric Study of ZZ Mic Variable Star
Authors: Mufidah D A , Armantara S A , Arkananta G G , Baihaqi M N S A , Syarif V , Mandey D 
Published: October 2024

Abstract
We report on the periodicity determination and O-C study of ZZ Mic, a short-period variable star. We used photometric data obtained on October 16, 2015 at Bosscha Observatory using the STEVia telescope (diameter 11 inches) and CCD ST8-XME. We also used 51 light curve data archives from the American Association of Variable Star Observers (AAVSO) database and 33 time of maxima records from various publications. The whole data set ranges from 1960 to 2015. We determine that ZZ Mic has a pulsation period of 0.067179 days with first overtone period of 0.053678 days. We fit the O-C diagram with a polynomial function we determine that the pulsation period of ZZ Mic has been decreasing at a rate of 8.28014 × 10−9 days per year. Using a known period-radius relation, we obtain the radius of ZZ Mic is 1.705 solar radii.
Optimizing Control of a Hybrid Quantum System of Nitrogen-Vacancy Centers and Superconducting Transmon Qubits
Authors: Muhammad Naseer , Majidi Muhammad A. 
Published: October 2024

Abstract
The control of hybrid quantum systems via the application of external fields is rapidly evolving field of research for the development of quantum applications and technologies. We model and optimize the dynamics of a hybrid quantum system consists of two non-local ensembles of nitrogen-vacancy centers and a superconducting transmon qubit mediated by two transmission line resonators. We apply a set of optimized time-dependent external driving field to enhance the system performance to function as a high fidelity state-to-state transfer. The Hamiltonian of the externally driven transmission line resonators is modelled by considering the non-linear transmons. The numerical simulation of the system is done using the optimized parameters of the external fields. By applying the optimized pulses, we have increased the fidelity of the state transfer from 0.7 to 1.0 within 100 ns. By varying the full wave half maxima value (FWHM) of the Gaussian pulse, it result in decreasing the amplitude of the fast oscillating states of the transmon and nitrogen-vacancy ensembles. These optimized external pulses also created a strong coupling between the components of under-consideration physical quantum system, which will eventually increase the fidelity of the system in a relatively faster time.
Interference effects in nonequilibrium quantum transport with long-range interactions
Authors: Ulfa Marisa , Dwiputra Donny 
Published: October 2024

Abstract
We investigate how long-range power-law hopping interaction, ∼ 1/r

a
, affects the characteristics of dissipative quantum transport in a nonequilibrium setting. The model under consideration is a noninteracting bosonic chain subject to thermal baths of differing temperature at its boundaries and dephasing noise which is applied uniformly to all the sites. It is shown that the steady-state current may vary nonmonotonically and has a peak for a finite a depending on the position of the cold bath. This site-specific behaviour stems back to the interference effect caused by the parity of the total sites N and the baths positions. The fractional nature of the system, along with the interplay between coherent and incoherent transport, will affect the steady state current that characterizes the transport.