bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic spontaneous urticaria in children ‐ a systematic review on interventions and comorbidities
Authors: Cornillier Hélène , Giraudeau Bruno , Munck Stéphane , Hacard Florence , Jonville‐Bera Annie‐Pierre , d'Acremont Gwenaëlle , Pham Bach‐Nga , Maruani Annabel 
Published: February 2018

AbstractBackgroundChronic spontaneous urticaria (CSU) is not frequent in children. Management guidelines have been developed for adults and randomized controlled trials (RCTs) included teenagers aged 12‐18, but data for children under age 12 are limited. We performed a systematic review to assess comorbidities in children <12 years old with CSU and the efficacy and safety of treatments.MethodsWe searched for original articles of epidemiologic and treatment data in children <12 years old with CSU that were published from 2005 to July 2016 in MEDLINE, EMBASE, CENTRAL, and LILACS. Article selection and data extraction were performed in duplicate.ResultsOur systematic review included 9 reports on epidemiologic data (633 children). Five comorbidities and laboratory anomalies associated with CSU found were atopy (28.1%), positive autologous serum skin test (36.8%), thyroid biologic anomalies (6.4%) and detectable antinuclear antigen (10.4%), seroprevalence for Helicobacter pylori (21.1%), low vitamin D level (69.1%), and psychiatric disorders (70.4%). Only one study allowed for comparison with a control group. Our review included 10 studies (322 children), describing 5 different drug families, mostly H1‐antihistamines (n = 297). One randomized controlled study compared single‐dose rupatadine with single‐dose desloratadine and placebo. Cyclosporine was effective and had no adverse effects in 18 children. Omalizumab, montelukast, and cefuroxime were reported in very small series (5, 1, and 1 patients).ConclusionsH1‐antihistamines are effective for CSU in children <12 years old, with reassuring safety data at licensed doses. Cyclosporine seems effective, but the level of evidence is low.
Textural characteristics and facies of sand‐rich contourite depositional systems
Authors: Brackenridge Rachel E. , Stow Dorrik A. V. , Hernández‐Molina Francisco J. , Jones Claudia , Mena Anxo , Alejo Irene , Ducassou Emmanuelle , Llave Estefanía , Ercilla Gemma , Nombela Miguel Angel , Perez‐Arlucea Marta , Frances Gillermo 
Published: February 2018

AbstractThis work presents a detailed study of CONTOURIBER and Integrated Ocean Drilling Program 339 sediment data targeting sand‐rich contourites in the Eastern Gulf of Cadiz. All of the collected sediments are interpreted as contourites (deposited or reworked by bottom currents) on the basis of oceanographic setting, seismic and morphometric features, and facies characteristics. A variety of sandy and associated facies are found across the study area including: (i) bioturbated muddy contourites; (ii) mottled silty contourites; (iii) very fine mottled and fine‐grained bioturbated sandy contourites; (iv) massive and laminated sandy contourites; and (v) coarse sandy/gravel contourites. The thickest sands occur within contourite channels and there is a marked reduction in sand content laterally away from channels. Complementary to the facies descriptions, grain‐size analysis of 675 samples reveals distinctive trends in textural properties linked to depositional processes under the action of bottom currents. The finest muddy contourites (<20 μm) show normal grain‐size distributions, poor to very poor sorting, and zero or low skewness. These are deposited by settling from weak bottom currents with a fine suspension load. Muddy to fine sandy contourites (20 to 200 μm) trend towards better sorting and initially finer and then coarser skew. These are typical depositional trends for contourites. As current velocity and carrying capacity increase, more of the finest fraction remains in suspension and bedload transport becomes more important. Clean sandy contourites (>200 μm) are better sorted. They result from the action of dominant bedload transport and winnowing at high current speeds. The results highlight the importance of bottom current velocity, sediment supply and bioturbational mixing in controlling contourite facies. Despite growing interest in their hydrocarbon exploration potential, contourite sands have remained poorly understood. This research therefore has important implications for developing current understanding of these deposits and aiding the correct interpretation of deep marine sands and depositional processes.
The end game: Mortality outcomes in North American professional athletes
Authors: Lemez S. , Wattie N. , Baker J. 
Published: February 2018

AbstractComprehensive investigations into the mortality outcomes of elite athletes can assist in decoding risk factors for premature mortality and provide avenues for exploring human health through engagement in sport. As such, the purpose of this study was to comprehensively examine lifespan trends of athletes from the 4 major sports in North America: Major League Baseball (MLB), National Basketball Association (NBA), National Football League (NFL), and National Hockey League (NHL). We hypothesized that proportional death rates would be similar across the 4 sports, when standardizing the data by debut years. Overall, 17 523 of 50 515 (34.7%) athletes were deceased as of the respective data collection cutoff date for their sport, with MLB players having the highest risk of imminent mortality. Professional basketball players generally had the highest relative proportion of death when standardizing data by debut year, although NHL and NFL players who debuted after 2005 had the highest proportion of death. In addition, a 1‐year increase in career length significantly decreased the risk of death (HR: 0.982, 95% CI: 0.978‐0.985), even after adjusting for sport type (HR: 0.977, 95% CI: 0.974‐0.980). Meaningful significance should be considered given the historical and unique nature of the sample. Nevertheless, investigating risk of death differences through different occupational and biological variables can help highlight aversive trends to lifespan that permeate throughout high‐performance athlete populations.
Is preventing peer victimization sufficient? The role of prosocial peer group treatment in children's socioemotional development
Authors: Troop‐Gordon Wendy , Unhjem Lexie 
Published: February 2018

AbstractDespite extensive research on the harmful effects of peer victimization, little is known about whether prosocial treatment from peers contributes to healthy socioemotional development. To address this issue, 366 third and fourth graders (170 boys; Mage = 9.34) were followed over three time points. Children completed measures of prosocial peer treatment, peer victimization, depressive affect, and friendship quality. Teacher‐reports of depressive affect and peer‐reports of aggression, victimization, and friendships were also obtained. Controlling for peer victimization, number of friends, and friendship quality, prosocial peer treatment negatively predicted depressive affect. For boys, prosocial peer treatment mediated the association between victimization and teacher‐reported depressive affect. These findings underscore the importance of prosocial peer group treatment and the need to broaden the goals of anti‐bullying interventions to include the promotion of positive peer interactions.
Retired Farmers and New Land Users: How Relations to Land and People Influence Farmers' Land Transfer Decisions
Authors: Grubbström Ann , Eriksson Camilla 
Published: February 2018

AbstractAccess to land is a key challenge for prospective farmers in Europe. Retiring family farmers who lack a successor resort to leasing or selling their land, but the decision has implications for the community and the rural landscape for generations to come. It is thus crucial to know more about values and decisions linked to keeping, leasing or selling land, and the opportunities these provide for young farmers seeking to establish a business. It is also important to consider the choice of lessee/buyer and the relationship between the former farmer and lessee/buyer. This study is based on interviews with retired farmers, young farmers and farm advisors in Sweden. The results revealed that the lessee/buyer tends to be carefully chosen by the outgoing farmer and that non‐monetary values and motivations, such as social interaction and concern for the environment, the rural community and the agricultural landscape are important. In some cases, the relationship between landowner/former farmer and lessee/buyer resembled family ties. The decision to lease/sell sometimes appeared to be a relief for the retiring farmer. For some lessees/buyers a close relationship with the former farmer provided valuable mentorship, while others valued the greater degree of freedom in leasing/buying compared with inheritance.
Beyond the neoliberal paradigm? Images of Social Europe in open method of coordination employment peer reviews
Authors: van Gerven Minna , Ossewaarde Marinus 
Published: February 2018

AbstractThis article seeks to understand how, within the open method of coordination peer review process, the European Union (EU) together with member states envision the processes of European integration within the employment policy field. Our theoretical framework draws light on alternatives, nuances, and tendencies of discursive potential for transcending the neoliberal image at the core of the European Social Policy literature. A content analysis of employment guidelines (1998–2015) and best practices in the peer review programs for employment policies (1999–2015) shows how the EU seeks to find credible roles for itself in employment policy and how in this process different ideas and even more practices prevail. We find clues for transcending the neoliberal picture, visions of a different Europe that is more in accord with the European values of liberal Social Europe and cosmopolitan Social Europe than is generally proposed in this context.
Evaluation of microRNA stability in feces from healthy dogs
Authors: Cirera Susanna , Willumsen Line M. , Johansen Thea T. , Nielsen Lise N. 
Published: February 2018

BackgroundGastrointestinal cancer accounts for approximately 8% of all canine malignancies. Early detection of cancer may have a tremendous impact on both treatment options and prognosis. MicroRNAs (miRNAs), a class of noncoding RNAs that can be found stably expressed in body fluids and feces, have been suggested as valuable human cancer biomarkers.ObjectivesThe purpose of the study was to investigate the feasibility of detecting miRNAs in canine feces and to determine the miRNA stability in fecal samples stored at different temperatures for different duration.MethodsThe levels of 4 Canine familiaris (cfa) miRNAs (cfa‐miR‐16, cfa‐miR‐20a, cfa‐miR‐21, and cfa‐miR‐92a) were investigated by quantitative real‐time PCR(qPCR) in fecal samples from 10 healthy dogs. Fecal samples were collected at 3 different time points and samples from the first time point were stored at different temperatures and for a different duration.ResultsA statistically significant difference was found in miRNA levels from samples stored at room temperature compared with samples stored at −20°C for cfa‐miR‐16 and cfa‐miR‐21. No significant difference was found in the level of the investigated miRNAs over time.ConclusionsOverall, miRNAs are present in dog feces at measurable levels. Some miRNAs seem to be subject to a higher degree of degradation in samples stored at room temperature for 24 hours compared with samples frozen after collection at −20°C. The investigated miRNAs were stably expressed over time. This study provides the basis for further research on miRNA expression profiles as biomarkers for gastrointestinal cancer in dogs.
Dorsal thermal necrosis in dogs: a retrospective analysis of 16 cases in the southwestern USA (2009–2016)
Authors: Schwartz Stephanne L. , Schick Anthea E. , Lewis Thomas P. , Loeffler Diana 
Published: February 2018

BackgroundProlonged sun exposure in high ambient temperatures has been recognized as a cause of thermal burns on the dorsal skin of dogs, termed dorsal thermal necrosis (DTN).Hypotheses/ObjectivesTo characterize the clinical presentation, histopathology and outcomes of 16 dogs diagnosed with DTN and to identify associated risk factors.AnimalsSixteen dogs diagnosed with DTN.MethodsMedical records from 2009 to 2016 were reviewed retrospectively. Inclusion criteria included: (i) historical solar exposure; (ii) dorsal burn injuries and (iii) histopathological findings consistent with DTN.ResultsThe majority of cases (15 of 16) occurred during warmer months (May–September) in the southwestern USA. Affected dogs had predominantly dark, short hair coats, whereas four of 16 dogs had lighter coat colours. Five dogs had naturally longer hair, but two hair coats had been recently clipped. Signs consistent with heat exhaustion or heatstroke were reported prior to the development of cutaneous lesions in four of 16 dogs. The most common skin lesions were alopecia, erythema, ulcerations, eschars/necrosis and crusts. Histological findings were consistent with other types of partial and full‐thickness thermal burns, and included coagulation necrosis in the majority of cases. Most dogs were treated supportively with analgesics and antimicrobial therapies. The majority of DTN wounds healed via second intention, although surgery was performed on two dogs.Conclusions and clinical importanceDorsal thermal necrosis should be considered as a differential diagnosis for dogs with dorsal cutaneous burns and a history of sun exposure in high external temperatures. Dogs with dark, short hair coats may be at an increased risk.
Efficacy and safety of sarolaner in the treatment of canine ear mite infestation caused by Otodectes cynotis: a non‐inferiority study
Authors: Becskei Csilla , Cuppens Otto , Mahabir Sean P. 
Published: February 2018

BackgroundVarious treatments are available for ear mite infestations in dogs.ObjectiveThe efficacy of sarolaner was evaluated against ear mite infestation caused by Otodectes cynotis in dogs and compared with topical moxidectin/imidacloprid in a single‐masked, multi‐centre field study.AnimalsClient‐owned dogs with O. cynotis infestation were treated monthly with oral sarolaner (n = 163) or topical moxidectin/imidacloprid (n = 78).MethodsThe presence of mites in the ear canals and the clinical signs associated with otoacariasis (including head shaking, pruritus/ear scratching, trauma or alopecia of the pinnae, and erythema, ulceration and debris in the ear canals) was evaluated on days 0, 14 and 30, and, if applicable, on day 60. Dogs were considered cured of mite infestation following one (on day 0) or two (on days 0 and 30) monthly treatments, if no live mites were found in either ear. Non‐inferiority was evaluated at days 14 and 30.ResultsParasitological cure was achieved in 76.4%, 90.5% and 93.3% of the sarolaner‐treated and in 53.9%, 63.5% and 66.7% of the moxidectin/imidacloprid‐treated dogs on days 14, 30 and 60, respectively. At study completion, on day 60 at the latest, parasitological cure was achieved overall in 99.4% of sarolaner‐treated and 87.8% of moxidectin/imidacloprid‐treated cases. The parasitological cure rate for sarolaner was non‐inferior to moxidectin/imidacloprid at days 14 and 30. The clinical signs of otoacariasis improved throughout the study in both groups. There were no treatment‐related adverse events.ConclusionsA single oral administration of sarolaner was safe and highly effective in the treatment of O. cynotis infestation in dogs.
Selected serum oxidative stress biomarkers in dogs with non‐food‐induced and food‐induced atopic dermatitis
Authors: Almela Ramón M. , Rubio Camila P. , Cerón José J. , Ansón Agustina , Tichy Alexander , Mayer Ursula 
Published: February 2018

BackgroundOxidative stress (OS) has been shown to be involved in the pathogenesis of human and canine atopic dermatitis (AD) through several distinct mechanisms. Selected serum biomarkers of OS (sbOS) have been validated in normal dogs and studied in several canine diseases. To the best of the authors’ knowledge, the sbOS evaluated in this study have not previously been described in canine AD.Hypothesis/ObjectivesThe aims of the study were to evaluate a panel of sbOS in dogs with food‐induced (FIAD) and non‐food‐induced (NFIAD) AD: cupric reducing antioxidant capacity (CUPRAC), ferrous oxidation‐xylenol orange (FOX), ferric reducing ability of the plasma (FRAP), paraoxonase‐1 (PON1), trolox equivalent antioxidant capacity (TEAC) and serum total thiol (THIOL). The aim was to compare these metabolites with those in healthy control dogs, and to correlate sbOS with validated pruritus and CADESI‐04 severity scales in dogs with AD.AnimalsForty six healthy, nine NFIAD and three FIAD client‐owned dogs were included.MethodsThe study was designed as a cohort study.ResultsThere were significant differences in atopic dogs when compared to healthy dogs for all of the sbOS analysed.Conclusions and clinical relevanceThese findings suggest that OS could play a role in the pathogenesis of canine NFIAD and FIAD. In addition, the evaluation of sbOS could be useful for precision medicine to help to detect atopic dogs that might benefit from antioxidant‐targeted therapies.
Day or overnight transfusion in critically ill patients: does it matter?
Authors: Aubron C. , Kandane‐Rathnayake R. K. , Andrianopoulos N. , Westbrook A. , Engelbrecht S. , Ozolins I. , Bailey M. , Murray L. , Cooper D. J. , Wood E. M. , McQuilten Z. K. ,   The Blood Observational Study investigators,   The ANZICS Clinical Trials Group
Published: February 2018

Background and objectivesThe timing of blood administration in critically ill patients is first driven by patients' needs. This study aimed to define the epidemiology and significance of overnight transfusion in critically ill patients.Materials and methodsThis is a post hoc analysis of a prospective multicentre observational study including 874 critically ill patients receiving red blood cells, platelets, fresh frozen plasma (FFP) or cryoprecipitate. Characteristics of patients receiving blood only during the day (8 am up until 8 pm) were compared to those receiving blood only overnight (8 pm up until 8 am). Characteristics of transfusion were compared, and factors independently associated with major bleeding were analysed.ResultsThe 287 patients transfused during the day only had similar severity and mortality to the 258 receiving blood products overnight only. Although bleeding‐related admission diagnoses were similar, major bleeding was the indication for transfusion in 12% of patients transfused in daytime only versus 30% of patients transfused at night only (P < 0·001). Similar total amount of blood products were transfused at day and night (2856 versus 2927); however, patients were more likely to receive FFP and cryoprecipitate at night compared with daytime. Overnight transfusion was independently associated with increased odds of major bleeding (odds ratio, 3·16, 95% confidence interval, 2·00–5·01).ConclusionTransfusion occurs evenly across day and night in ICU; nonetheless, there are differences in type of blood products administered that reflect differences in indication. Critically ill patients were more likely to receive blood for major bleeding at night irrespective of admission diagnosis.
The haemovigilance: the best quality management system of the transfusion chain?
Authors: Liang WB. , Zhang RY. , Ye XF. , Sun J. , Xu J. , Tan WB. 
Published: February 2018

Background and ObjectivesHaemovigilance is an integral part of blood safety worldwide. Many haemovigilance systems are already in place or are developing, and national or regional haemovigilance systems have been implemented in several countries. In 2016, the WHO Global Database on Blood Safety reported that national haemovigilance system had been established in 70 countries, among which 38 countries were members of the International Haemovigilance Network by the end of August 2017. In this review, we retrospect the development and current status of haemovigilance to outline its function in transfusion chain.Materials and MethodsThrough contrasting the evolution of haemovigilance definition in different periods, by analysing its scope and breadth, and with the illustrating its achievements and challenges, we retrospect the development and current status of haemovigilance to outline its function in transfusion chain.ResultsHaemovigilance is becoming an important aspect of transfusion medicine,could be used as quality indicator for monitoring the blood transfusion safety, contribute significantly to evidence‐based transfusion medicine and results in improved policies, procedures and practices in the blood transfusion chain.ConclusionsThe scope of haemovigilance may cover the whole transfusion chain, from collection of blood and its components to follow‐up of recipients. Haemovigilance is an essential component of quality management in a blood system and haemovigilance is the best quality management system of the transfusion chain.
Ultrasound and computed tomography of sacculitis and appendicitis in a rabbit
Authors: Longo Maurizio , Thierry Florence , Eatwell Kevin , Schwarz Tobias , del Pozo Jorge , Richardson Jenna 
Published: February 2018

AbstractA 9‐month‐old neutered male rabbit was referred for lethargy, anorexia, and gastrointestinal stasis. Routine hematology, serum biochemistry, and diagnostic imaging were performed. Computed tomography revealed a wall thickening of the sacculus rotundus and appendix, which was further confirmed on abdominal ultrasound. Full thickness biopsies were collected with histopathology diagnosing a chronic multifocal heterophilic granulomatous sacculitis and appendicitis. The patient was treated medically and at 6 weeks follow‐up, clinical signs and intestinal changes had completely regressed. Inflammation of the sacculus rotundus and appendix should be considered as a cause of gastrointestinal stasis in rabbits.