bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of hepatitis C genotype 1 infection in Germany: effectiveness and safety of antiviral treatment in a real‐world setting
Authors: Höner zu Siederdissen Christoph , Buggisch Peter , Böker Klaus , Schott Eckart , Klinker Hartwig , Pathil Anita , Pfeiffer‐Vornkahl Heike , Berg Thomas , Sarrazin Christoph , Hüppe Dietrich , Manns Michael P , Mauss Stefan 
Published: June 2017

BackgroundIn pivotal studies with direct‐acting antivirals (DAAs), rates of sustained virological response in hepatitis C genotype 1 infection are >90%.ObjectiveThe objective of this article is to assess real‐world safety and effectiveness of DAA treatment in a prospective multicenter registry study.MethodsThe German Hepatitis C‐Registry includes 6606 patients with genotype 1 from 246 centers, treated between February 2014 and June 2016 at the discretion of the physician.ResultsA total of 4846 patients completed treatment and follow‐up; 51% of these patients were treatment experienced and 28% had liver cirrhosis. Comorbidities were reported in 76% of patients, including HIV co‐infection in 8%. SVR12 was 92% with 91% in GT1a and 93% in GT1b. HIV co‐infected patients (n  = 247) had an SVR12 of 92%. Treatment was discontinued prematurely in 2.5%. In multivariate analysis, SVR12 was dependent on the choice of antiviral regimen (OR 1.33 (1.24–1.43); p  < 0.001), negatively associated with presence of liver cirrhosis (OR 0.71 (0.56–0.89); p  < 0.003) and positively associated with female gender (OR 1.52 (1.21–1.91); p  < 0.001).ConclusionData from this real‐world registry show SVR12 rates close to those obtained in clinical studies. Discontinuation rates are low, confirming good tolerance of the regimens and good adherence of patients (Trial registration number DRKS00009717, German Clinical Trials Register, DRKS).
Fluorcaphite from hydrothermally altered teschenite at Tichá, Outer Western Carpathians, Czech Republic: compositional variations and origin
Authors: Kropáč Kamil , Dolníček Zdeněk , Uher Pavel , Urubek Tomáš 
Published: June 2017

AbstractFluorcaphite [SrCaCa3(PO4)3F] is a rare strontium-calcium member of the apatite supergroup which was previously known only from the Khibiny and Lovozero alkaline complexes. This paper presents evidence of a third fluorcaphite occurrence. It was found in hydrothermally altered Lower Cretaceous teschenite, which forms an intrusive body (probably a sill) in the Lower Cretaceous siliciclastic flysch sediments at Tichá near Frenštát pod Radhoštěm, Silesian Unit, Outer Western Carpathians (Czech Republic). Fluorcaphite occurs as an accessory mineral in hydrothermal veins and in an adjacent alteration zone within the host teschenite. Vein-hosted fluorcaphite forms euhedral crystals and skeletal crusts enclosed in analcime while the teschenite-hosted fluorcaphite forms small overgrowths on older phenocrysts of magmatic apatite. Fluorcaphite from Tichá contains 0.50–1.97 Sr apfu, 2.96–4.49 Ca apfu, 0.59–1.09 F apfu and significantly lower Na (0.01–0.05 apfu) and LREE contents (up to 0.07 apfu). Fluorcaphite formed under hydrothermal conditions after solidification of the host teschenite during post-magmatic hydrothermal activity at temperatures probably between ∼150 and 300°C. The initial 87Sr/86Sr ratio of vein-hosted analcime +fluorcaphite (0.7063) is significantly higher than those of the host teschenite (0.7041). We therefore suggest a mix of strontium sources in the vein analcime+fluorcaphite: (1) from the host teschenite plus (2) from external source(s) including the Lower Cretaceous seawater and/or surrounding sedimentary rocks of the Silesian Unit. These data indicate an open-system fluid regime and the participation of various fluid sources during the alteration event giving rise to fluorcaphite.
Characteristics and formation processes of (Ba, K, NH4)-feldspar and cymrite from a lower Cambrian black shale sequence in Anhui Province, South China
Authors: Chang Chao , Hu Wen-Xuan , Fu Qi , Cao Jian , Wang Xiao-Lin , Wan Ye , Yao Su-Ping 
Published: June 2017

ABSTRACTBarium-rich silicates were recently found in the lower Cambrian black shale sequence of Anhui Province, South China. The Ba silicates can be divided into Ba-poor K-feldspar, Ba-rich K-feldspar and cymrite, on the basis of occurrence and composition. The Ba-poor K-feldspar have low BaO contents (<1.00 wt.%) and occur as sporadic grains in mudstone. In contrast, the Ba-rich K-feldspar have higher BaO contents (1.36–20.51 wt.%) and occur mainly as rims around grains of Ba-poor K-feldspar in mudstone, as void fillings in dolostone, and as grains dispersed in chert. The cymrite is observed only in chert and occurs as dispersed euhedral tabular crystals. Analyses of the Ba-poor K-feldspar and Ba-rich K-feldspar provide compositions that total <100 wt.% and show non-stoichiometry characterized by (Na + K + Ba + Ca)apfu less than 1.00 and (Al + Si)apfu slightly higher than 4.00. Raman and infrared (IR) spectroscopy has revealed the presence of ${\rm NH}_{\rm 4}^{\rm +} $ and H2O in the Ba-rich K-feldspar, which accounts for the unusual composition of these feldspars. We suggest that the formation processes of the Ba-poor K-feldspar, Ba-rich K-feldspar and cymrite were closely associated with multi-stage hydrothermal fluids enriched in Ba and NH4, consistent with an extensional tectonic setting during the early Cambrian. The Ba-poor K-feldspars might have formed through interactions between pre-existing K-feldspars and hydrothermal fluids. The Ba-rich K-feldspars in mudstone and dolostone formed mainly by precipitation from hydrothermal fluids that infiltrated the sediments, and we suggest the Ba-rich K-feldspars and cymrite in the chert are of exhalative hydrothermal origin.
Synthesis and characterization of wollastonite-2Mby using a diatomite precursor
Authors: Novembre Daniela , Pace Carla , Gimeno Domingo 
Published: June 2017

ABSTRACTSolid phase reaction synthesis of wollastonite-2Mby a natural rock precursor as the source of amorphous silica and CaCO3is reported. Chemical treatments were carried out on a diatomitic rock from Crotone (Calabria, Italy) in order to measure its reactive silica and CaCO3contents. Four series of synthesis were performed at 1000°C at ambient pressure by mixing, at different stoichiometry, the diatomitic rock with a natural limestone as a source of additive CaCO3, and sodium carbonate (Na2CO3) as triggering agent.Wollastonite-2Mwas characterized by chemo-physical, crystallographical and morphological-microtextural analyses. All these characterizations, together with infrared and nuclear magnetic resonance (29Si) responses provide values comparable to literature data. Estimation of the amorphous phase in the synthesis powders was performed through quantitative phase analysis using the combined Rietveld and reference intensity ratio methods, resulting in a final product of 96.3% wollastonite-2M.
Melcherite, trigonal Ba2Na2Mg[Nb6O19]·6H2O, the second natural hexaniobate, from Cajati, São Paulo, Brazil: Description and crystal structure
Authors: Andrade Marcelo B. , Atencio Daniel , Menezes Filho Luiz A. D. , Spratt John 
Published: June 2017

ABSTRACTMelcherite (IMA2015-018), ideally Ba2Na2Mg[Nb6O19]·6H2O, occurs as a vug mineral in the carbonatite of the Jacupiranga mine, Cajati county, São Paulo state, Brazil, associated with dolomite, calcite, magnetite, pyrrhotite, tochilinite, ‘pyrochlore’ and fluorapatite. This is also the type locality for zirkelite, quintinite, menezesite and pauloabibite. The mineral forms irregular, tabular crystals up to 200 µm in maximum dimension. Melcherite is transparent and displays a vitreous lustre; it is beige with a white streak. It is non-fluorescent. The mineral displays perfect cleavage on {001}. Chemical composition varies from Ba2Na2Mg[Nb6O19].6H2O to (BaK)(NaCa)Mg[Nb6O19].6H2O. Empirical formulae for the first and the second compositions are: (Ba1.75K0.19)Σ1.94(Na1.80Ca0.19)Σ1.99(Mg0.96Mn0.02Al0.02)Σ1.00Nb6.02O19.00·6H2O and (Ba0.99K1.00)Σ1.99(Na1.02Ca0.96)Σ1.98(Mg0.95Mn0.05)Σ1.00Nb6.02O19.00·6H2O, respectively. Data for a single crystal with the second composition are: trigonal, R$\bar 3$, a = 9.0117(6) Å, c = 23.3986(16) Å, V = 1645.64(19) Å3 and Z = 3. Calculated density for this formula is 3.733 g/cm3, and the calculated mean refractive index is 1.924. Melcherite is a hexaniobate that has structural layers parallel to the xy plane that stack along the c axis with simultaneous 1/3 [110] displacement so as to produce an R lattice. The melcherite structure is built by layers of [(Ba,K)(O,H2O)9] polyhedra and the [Nb6O19]8− super-octahedron (Lindqvist anion) interconnected by [(Na,Ca)O6] polyhedra. Cations of Mg2+ are bonded to six water molecules each and are not associated with Lindqvist oxygen ions. The mineral is named in honour of Geraldo Conrado Melcher (1924–2011), a pioneer in Jacupiranga carbonatite studies.
Fluorlamprophyllite, Na3(SrNa)Ti3(Si2O7)2O2F2, a new mineral from Poços de Caldas alkaline massif, Morro do Serrote, Minas Gerais, Brazil
Authors: Andrade Marcelo B. , Yang Hexiong , Downs Robert T. , Färber Gunnar , Contreira Filho Reynaldo R. , Evans Stanley H. , Loehn Clayton W. , Schumer Benjamin N. 
Published: June 2017

ABSTRACTA new mineral species, fluorlamprophyllite (IMA2013-102), ideally Na3(SrNa)Ti3(Si2O7)2O2F2, has been found in the Poços de Caldas alkaline massif, Morro do Serrote, Minas Gerais, Brazil. Alternatively, the idealized chemical formula could be written as (SrNa)[(Na3Ti)F2][Ti2(Si2O7)2O2], setting the large interlayer cations before the cations of the layer. Fluorlamprophyllite is the F-analogue of lamprophyllite. It is associated with aegirine, analcime, natrolite, nepheline and microcline. Fluorlamprophyllite crystals are brownish-orange and bladed. The mineral is transparent with a pale yellow streak and an adamantine lustre. It is brittle and has a Mohs hardness of ~3; cleavage is perfect on {100} and no parting was observed. The calculated density is 3.484 g/cm3. Optically, fluorlamprophyllite is biaxial (+), with α = 1.735(7), β = 1.749(7) and γ = 1.775(9) and 2Vmeas = 72(3)°. An electron microprobe analysis produced an average composition (wt.%) (9 points) of Na2O 10.63(30), K2O 0.47(3), SiO2 30.51(13), SrO 18.30(24), MgO 0.81(17), Al2O3 0.23(2), CaO 1.11(7), MnO 5.03(38), TiO2 27.41(87), Fe2O3 2.45(37), F 2.86(23), plus H2O 1.00 (added to bring the total close to 100%), –O = F –1.20, with the total = 98.61%. The elements Nb and Ba were sought, but contents were below microprobe detection limits. The resultant chemical formula was calculated on the basis of 18 (O + F) atoms per formula unit. The addition of 1.00 wt.% H2O brought [F+(OH)] = 2 pfu, yielding (Na2.63Sr1.35Mn0.54Ca0.15Mg0.15K0.08)Σ4.90(Ti2.63Fe0.24Al0.04)Σ2.91Si3.89O16[F1.15(OH)0.85]Σ2.00. The mineral is monoclinic, with space group C2/m and unit-cell parameters a = 19.255(2), b = 7.0715(7), c = 5.3807(6) Å, β = 96.794(2)° and V = 727.5(1) Å3. The structure is a layered silicate inasmuch as the O atoms are arranged in well-defined, though not necessarily close-packed layers.
Parisite-(La), ideally CaLa2(CO3)3F2, a new mineral from Novo Horizonte, Bahia, Brazil
Authors: Menezes Filho Luiz A. D. , Chaves Mario L. S. C. , Chukanov Nikita V. , Atencio Daniel , Scholz Ricardo , Pekov Igor , da Costa Geraldo Magela , Morrison Shaunna M. , Andrade Marcelo B. , Freitas Erico T. F. , Downs Robert T. , Belakovskiy Dmitriy I. 
Published: June 2017

ABSTRACTParisite-(La) (IMA2016-031), ideally CaLa2(CO3)3F2, occurs in a hydrothermal vein crosscutting a metarhyolite of the Rio dos Remédios Group, at the Mula mine, Tapera village, Novo Horizonte county, Bahia, Brazil, associated with hematite, rutile, almeidaite, fluocerite-(Ce), brockite, monazite-(La), rhabdophane-(La) and bastnäsite-(La). Parisite-(La) occurs as residual nuclei (up to 5 mm) in steep doubly-terminated pseudo-hexagonal pyramidal crystals (up to 8.2 cm). Parisite-(La) is transparent, yellow-green to white, with a white streak and displays a vitreous (when yellow-green) to dull (when white) lustre. Cleavage is distinct on pseudo-{001}; fracture is laminated, conchoidal, or uneven. The Mohs hardness is 4 to 5, and it is brittle. Calculated density is 4.273 g cm−3. Parisite-(La) is pseudo-uniaxial (+), ω = 1.670(2) and ε = 1.782(5) (589 nm). The empirical formula normalized on the basis of 11 (O + F) atoms per formula unit (apfu) is Ca0.98(La0.83Nd0.51Ce0.37Pr0.16Sm0.04Y0.03)Σ1.94C3.03O8.91F2.09. The IR spectrum confirms the absence of OH groups. Single-crystal X-ray studies gave the following results: monoclinic (pseudo-trigonal), space group: C2, Cm, or C2/m, a = 12.356(1) Å, b = 7.1368(7) Å, c = 28.299(3) Å, β = 98.342(4)°, V = 2469.1(4) Å3 and Z = 12. Parisite-(La) is the La-dominant analogue of parisite-(Ce).
The palisade cartilage tympanoplasty technique: A systematic review and meta-analysis
Authors: Jeffery Caroline C. , Shillington Cameron , Andrews Colin , Ho Allan 
Published: June 2017

Background Tympanoplasty is a common procedure performed by Otolaryngologists. Many types of autologous grafts have been used with variations of techniques with varying results. This is the first systematic review of the literature and meta-analysis with the aim to evaluate the effectiveness of one of the techniques which is gaining popularity, the palisade cartilage tympanoplasty. PubMed, EMBASE, and Cochrane databases were searched for “palisade”, “cartilage”, “tympanoplasty”, “perforation” and their synonyms. Main body of abstract In total, 199 articles reporting results of palisade cartilage tympanoplasty were identified. Five articles satisfied the following inclusion criteria: adult patients, minimum 6 months follow-up, hearing and surgical outcomes reported. Studies with patients undergoing combined mastoidectomy, ossicular chain reconstruction, and/or other middle ear surgery were excluded. Perforation closure, rate of complications, and post-operative pure-tone average change were extracted for pooled analysis. Study failure and complication proportions that were used to generate odds ratios were pooled. Fixed effects and random effects weightings were generated. The resulting pooled odds ratios are reported. Palisade cartilage tympanoplasty has an overall take rate of 96% at beyond 6 months and has similar odds of complications compared to temporalis fascia (OR 0.89, 95% CI 0.62, 1.30). The air-bone gap closure is statistically similar to reported results from temporalis fascia tympanoplasty. Conclusions Cartilage palisade tympanoplasty offers excellent graft take rates and good postoperative hearing outcomes for perforations of various sizes and for both primary and revision cases. This technique has predictable, long-term results with low complication rates, similar to temporalis fascia tympanoplasty.
Perpetual change: autophagy, the endothelium, and response to vascular injury
Authors: Sachdev Ulka , Lotze Michael T 
Published: June 2017

Abstract
Current studies of vascular health, aging, and autophagy emphasize how the endothelium adapts to stress and contributes to disease. The endothelium is far from an inert barrier to blood-borne cells, pathogens, and chemical signals; rather, it actively translates circulating mediators into tissue responses, changing rapidly in response to physiologic stressors. Macroautophagy—the cellular ingestion of effete organelles and protein aggregates to provide anabolic substrates to fuel bioenergetics in times of stress—plays an important role in endothelial cell homeostasis, vascular remodeling, and disease. These roles include regulating vascular tone, sustaining or limiting cell survival, and contributing to the development of atherosclerosis secondary to infection, inflammation, and angiogenesis. Autophagy modulates these critical functions of the endothelium in a dynamic and perpetual response to tissue and intravascular cues.
Quantum Cryptography: Key Distribution and Beyond
Authors: Shenoy-Hejamadi Akshata , Pathak Anirban , Radhakrishna Srikanth 
Published: June 2017

<p>Uniquely among the sciences, quantum cryptography has driven both foundational research as well as practical real-life applications. We review the progress of quantum cryptography in the last decade, covering quantum key distribution and other applications.</p><p>Quanta 2017; 6: 1–47.</p>
POSTPARTUM BLUES PADA PERSALINAN DIBAWAH USIA DUA PULUH TAHUN
Authors: Pratiwi Kurniasari , Chasanah Istiani Nur , Martuti Sri 
Published: June 2017

Postpartum blues or baby blues is a feeling of sadness experienced by mothers after childbirth related to the baby. Postpartum blues is like an iceberg that is difficult to detect because there are still many people who do not understand about the event. Nevertheless, postpartum blues not being handled properly is one of the factors precipitating the occurrence of postpartum depression, can be fatal for mother and baby. Postpartum blues more common in women who marry in their early age. Indonesia has high percentage of early age marriage in the world (ranked 37) and is the second highest in ASEAN after Cambodia. Based on data, there was increasing number of woman cases delivering labor and having children in the village Panggungharjo Sewon Bantul from year 2013 to 2015. Research objectives are to determine the postpartum blues in labor under the age of 20 years. This study is a descriptive study with retrospective design. The study population consists of women who gave birth under the age of 20 years in the village of Panggungharjo, Sewon, Bantul using total sampling (33 subjects). The result showed that 45.5% of respondents who experienced postpartum blues and 54.5% did not experience postpartum blues.
Shape Selectivity of Middle Superior Temporal Sulcus Body Patch Neurons
Authors: Kalfas Ioannis , Kumar Satwant , Vogels Rufin 
Published: June 2017

AbstractFunctional MRI studies in primates have demonstrated cortical regions that are strongly activated by visual images of bodies. The presence of such body patches in macaques allows characterization of the stimulus selectivity of their single neurons. Middle superior temporal sulcus body (MSB) patch neurons showed similar stimulus selectivity for natural, shaded, and textured images compared with their silhouettes, suggesting that shape is an important determinant of MSB responses. Here, we examined and modeled the shape selectivity of single MSB neurons. We measured the responses of single MSB neurons to a variety of shapes producing a wide range of responses. We used an adaptive stimulus sampling procedure, selecting and modifying shapes based on the responses of the neuron. Forty percent of shapes that produced the maximal response were rated by humans as animal-like, but the top shape of many MSB neurons was not judged as resembling a body. We fitted the shape selectivity of MSB neurons with a model that parameterizes shapes in terms of curvature and orientation of contour segments, with a pixel-based model, and with layers of units of convolutional neural networks (CNNs). The deep convolutional layers of CNNs provided the best goodness-of-fit, with a median explained explainable variance of the neurons’ responses of 77%. The goodness-of-fit increased along the convolutional layers’ hierarchy but was lower for the fully connected layers. Together with demonstrating the successful modeling of single unit shape selectivity with deep CNNs, the data suggest that semantic or category knowledge determines only slightly the single MSB neuron’s shape selectivity.
OH MYeloid! Immune cells wreaking havoc on brain homeostasis
Authors: Bonanno Liana , Wyss‐Coray Tony 
Published: June 2017

Genetic mutations responsible for neurodegenerative Nasu‐Hakola disease have been localized to the geneTREM2 and its adaptorDAP12, but it remained unclear what causes the brain to deteriorate. In this issue ofTheEMBOJournal, Kleinbergeret al(2017) provide intriguing evidence suggesting aTREM2 mutation alone can lead to striking microglial dysfunction and precipitate changes in cerebral blood flow and metabolism in mice.
Suppressing mTORC1 on the lysosome
Authors: Raiborg Camilla , Schink Kay O , Stenmark Harald 
Published: June 2017

The mechanistic target of rapamycin, mTOR, is a protein kinase that integrates environmental and nutritional inputs into regulation of cell growth and metabolism. Key outputs of mTOR signalling occur from the lysosome membrane in the form of the multi‐subunit mTOR complex 1 (mTORC1), which phosphorylates multiple targets. While class I phosphoinositide kinase (PI3K‐I) is a well‐known activator of mTORC1, a recent paper (Marat et al, 2017) shows that a class II PI3K with a different substrate specificity, PI3K‐C2β, serves to inhibit mTORC1 on lysosomes under conditions of growth factor deprivation.
Gli1‐induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1
Authors: Zhou Aidong , Lin Kangyu , Zhang Sicong , Ma Li , Xue Jianfei , Morris Saint‐Aaron , Aldape Kenneth D , Huang Suyun 
Published: June 2017

AbstractAberrant activation of the Hedgehog (Hh) signaling pathway drives the tumorigenesis of multiple cancers. In this study, we screened a panel of deubiquitinases that may regulate the Hh pathway. We find that deubiquitinase USP48 activates Gli‐dependent transcription by stabilizing Gli1 protein. Mechanistically, USP48 interacts with Gli1 and cleaves its ubiquitin off directly. In glioblastoma cells, knockdown of USP48 inhibits cell proliferation and the expression of Gli1's downstream targets, which leads to repressed glioblastoma tumorigenesis. Importantly, USP48's effect on cell proliferation and tumorigenesis depends to some extent on Gli1. In addition, we find that the Sonic Hedgehog (SHH) pathway induces USP48 expression through Gli1‐mediated transcriptional activation, which forms thus a positive feedback loop to regulate Hh signaling. In human glioblastoma specimens, the expression levels of USP48 and Gli1 proteins are clinically relevant, and high expression of USP48 correlates with glioma malignancy. In summary, our study reveals that the USP48‐Gli1 regulatory axis is critical for glioma cell proliferation and glioblastoma tumorigenesis.
Sociocultural Component of Teachers’ Professional Competence
Authors: Stakhiv Maria , Boiko Halyna 
Published: June 2017

This article considers the theoretical and practical issues of sociocultural competence of Ukrainian students of higher educational institutions; the priorities of the sociocultural education paradigm were analyzed; in this context, the issue of training future teachers to work in terms of a personality oriented teaching approach was presented.
On the basis of the analysis conducted on psycho-pedagogical and methodological literature that covers the raised problems, a number of methodological and pedagogical ideas which provide for the formation of social and cultural mobility of future teachers were determined in order to ensure pupils’ sociocultural development