bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wyzwania wychowawcze w rodzinie zastępczej
Authors: Duda Małgorzata 
Published: May 2017

Dyskusja ostatnich lat w obszarze funkcjonowania rodziny współczesnej nie słabnie – podkreślane jest jej znaczenie, ale jednocześnie wskazuje się zagrożenie w realizacji jej funkcji opiekuńczo­‑wychowawczej. Młodzi ludzie decydujący się na założenie rodziny coraz częściej nie są przygotowani do wyzwań, jakie stawia przed nimi społeczeństwo. Dotyczy to zwłaszcza funkcji rodzicielskiej – coraz więcej dzieci potrzebuje rodziny zastępczej, która otoczy ich – przede wszystkim – miłością, zapewni poczucie bezpieczeństwa. Czy rzeczywiście funkcjonowanie rodziny zastępczej różni się od życia w rodzinie pochodzenia? Jeżeli tak, to co należy robić, by różnice te były jak najmniejsze? Czy w ogóle jest to możliwe? Wreszcie – czy istnieje różnica w realizowaniu funkcji opiekuńczo­‑wychowawczej „wczoraj” i „dzisiaj”? Na te i inne pytania spróbuje odpowiedzieć niniejszy artykuł.
First-Line Palliative HER2-Targeted Therapy in HER2-Positive Metastatic Breast Cancer Is Less Effective After Previous Adjuvant Trastuzumab-Based Therapy
Authors: Rier Hánah N. , Levin Mark-David , van Rosmalen Joost , Bos Monique M. E. M. , Drooger Jan C. , de Jong Paul , Portielje Johanneke E. A. , Elsten Elisabeth M. P. , Ten Tije Albert-Jan , Sleijfer Stefan , Jager Agnes 
Published: May 2017

Abstract

Background
Survival of patients with human epidermal growth receptor 2 (HER2)-positive metastatic breast cancer (MBC) has improved dramatically since trastuzumab has become available, although the disease eventually progresses in most patients. This study investigates the outcome (overall survival [OS] and time to next treatment [TNT]) in MBC patients pretreated with trastuzumab in the adjuvant setting (TP-group) compared with trastuzumab-naïve patients (TN-group) in order to investigate the possibility of trastuzumab resistance.

Patients and Methods
Patients treated with first-line HER2-targeted-containing chemotherapy were eligible for the study. A power analysis was performed to estimate the minimum size of the TP-group. OS and TNT were estimated using Kaplan-Meier curves and multivariable Cox proportional hazards models.

Results
Between January 1, 2000, and June 1, 2014, 469 patients were included, of whom 82 were in the TP-group and 387 were in the TN-group. Median OS and TNT were significantly worse in the TP-group compared with the TN-group (17 vs. 30 months, adjusted hazard ratio [HR] 1.84 [1.15–2.96], p = .01 and 7 vs. 13 months, adjusted HR 1.65 [1.06–2.58], p = .03) after adjustment for age, year of diagnosis, disease-free interval, hormone receptor status, metastatic site, and cytotoxic regimens.

Conclusion
First-line trastuzumab-containing treatment regimens are less effective in patients with failure of adjuvant trastuzumab compared with trastuzumab-naïve patients and might be due to trastuzumab resistance. The impact of trastuzumab resistance on the response on dual HER2 blockade with trastuzumab and pertuzumab and how resistance mechanisms can be used in the optimization of HER2-targeted treatment lines need further investigation.
Weekly Low-Dose Versus Three-Weekly High-Dose Cisplatin for Concurrent Chemoradiation in Locoregionally Advanced Non-Nasopharyngeal Head and Neck Cancer: A Systematic Review and Meta-Analysis of Aggregate Data
Authors: Szturz Petr , Wouters Kristien , Kiyota Naomi , Tahara Makoto , Prabhash Kumar , Noronha Vanita , Castro Ana , Licitra Lisa , Adelstein David , Vermorken Jan B. 
Published: May 2017

AbstractBackgroundThree-weekly high-dose cisplatin (100 mg/m2) is considered the standard systemic regimen given concurrently with postoperative or definitive radiotherapy in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). However, due to unsatisfactory patient tolerance, various weekly low-dose schedules have been increasingly used in clinical practice. The aim of this meta-analysis was to compare the efficacy, safety, and compliance between these two approaches.Materials and MethodsWe systematically searched literature for prospective trials of patients with LA-SCCHN who received postoperative or definitive conventionally fractionated concurrent chemoradiation. Radiation doses were usually 60–66 gray (Gy) in the postoperative setting and 66–70 Gy in the definitive setting. Standard, three-weekly high-dose cisplatin (100 mg/m2, 3 doses) was compared with the weekly low-dose protocol (≤50 mg/m2, ≥6 doses). The primary endpoint was overall survival. Secondary outcomes comprised response rate, acute and late adverse events, and treatment compliance.ResultsFifty-two studies with 4,209 patients were included in two separate meta-analyses according to the two clinical settings. There was no difference in treatment efficacy as measured by overall survival or response rate between the chemoradiation settings with low-dose weekly and high-dose three-weekly cisplatin regimens. In the definitive treatment setting, the weekly regimen was more compliant and significantly less toxic with respect to severe (grade 3–4) myelosuppression (leukopenia p = .0083; neutropenia p = .0024), severe nausea and/or vomiting (p &lt; .0001), and severe nephrotoxicity (p = .0099). Although in the postoperative setting the two approaches were more equal in compliance and with clearly less differences in the cisplatin-induced toxicities, the weekly approach induced more grade 3–4 dysphagia (p = .0026) and weight loss (p &lt; .0001).ConclusionIn LA-SCCHN, current evidence is insufficient to demonstrate a meaningful survival difference between the two dosing regimens. Prior to its adoption into routine clinical practice, the low-dose weekly approach needs to be prospectively compared with the standard three-weekly high-dose schedule.
Characteristics of Staphylococcus aureus Isolated Smoked Fish Pinekuhe from Traditionally Processed from Sangihe District
Authors: Karimela Ely John , Ijong Frans G. , Dien Henny A. 
Published: May 2017

Pinekuhe is the local name for smoked scad fish (Decapterus sp.), a traditionally processed fish product from Sangihe Islands whose taste, aroma and form are typical and unique. In this research aims of physiological and biochemical characteristics with pathogenicity isolated S. aureus which the isolated from the product smoked scad fish (Decapterus rusellii) Pinekuhe it was produce and prepared by the local fisherman in Sangihe Island Regency. The isolated that have gathered from this researched was 111 product isolate from the smoke fish Pinekuhe which grown from media MSA. Its had isolated already through the<br />test of physiological comprise, Gram staining and from the test of biochemical e.g., from the test Catalase, Voges-Proskauer, and Fermentation carbohydrate tests (Glucose and Manitol). The characteristics of pathogenicity S. aureus had been done and used by making of Coagulase, Nuklease Thermostabil production<br />and deoksiribonuklease (DNase). The result of this research showing that had still 111 isolating strains that still ingroup which consists of 108 isolated Staphylococcus and from 108 strains to 68 strains that had been test in identifying, as of Staphylococcus aureus with characteristics of Gram positif coccus, catalase positif,<br />Voges-Proskauer positif, and to Fermentation Glucose and Manitol. The 68 isolate S. aureus that characterize from Phatogen principles product Coagulase test, Nuklease Thermostabil and deoksiribonuklease (DNase). S. aureus is dominant (62%) contaminate smoked fish Pinekuhe processed traditional of Sangihe island.
Bioactive Compounds of Seaweed Padina australis and Eucheuma cottonii as Sunscreen Raw Materials
Authors: Maharany Fevita , Nurjanah Nurjanah , Suwandi Ruddy , Anwar Effionora , Hidayat Taufik 
Published: May 2017

Seaweed is one of the main commodity which spread throughout Indonesian waters. Seaweed contains bioactive compounds which can serve as a defense form ultraviolet radiation. The purpose of this study was to obtain chemical composition, phytochemical compounds, vitamin E, and antioxidant activity of extract P. australis and E. cottonii. Chemical composition of P. australis moisture 87.25%; ash 2.34%; protein 1.05%, fat 0.58%; and carbohydrates 8.78% while E. cottonii moisture 76.15%; ash 5.62%; protein 2.32%; fat 0.11%; and carbohydrates 15.8%. The yield of P. australis extracts using methanol 4.55%; ethyl acetate 0.8%; and n-hexane 0.45%, yield of E. cottonii extracts using methanol 6.6%; ethyl acetate 0.5%; and and n-hexane 0.35%. Vitamin E value of P. australis 162.75 μg/mL and E. cottonii 158.07 μg/mL. IC50 value of P. australis 87.082 ppm and E. cottonii 106.021 ppm. P. australis and E. cottonii contain phytochemical compound such as flavonoids, phenol hydroquinone, and triterpenoids, P. australis was also known contain tannins and<br />saponins.
The clinico-demographic study of morbidity and mortality in patients with organophosphate compound poisoning at tertiary care hospital in rural India
Authors: Mundhe Sanjay A. , Birajdar Siddheshwar V. , Chavan Sheshrao S. 
Published: May 2017

Background: Organophosphates (OP) are commonly used and potentially fatal insecticides. Given the unrestricted availability and widespread use, OP poisoning is very much common following either accidental or intentional exposures. Many parameters are proposed to predict outcome, yet there is no consensus about these parameters. This study aimed to investigate different factors associate with morbidity and mortality in rural population that can help in identifying patients in need of intensive care and treatment to prevent deaths.Methods: This was a cross-sectional observational study of 323 patients, admitted to the tertiary care rural public hospital with OP poisoning between December 2015 to November 2016.Results: Of the 323 patients studied, 62.85% were male, 227 (70.27%) were suicides, 241 (74.61%) ingested OP compounds, 40 (12.38%) patients developed intermediate syndrome and 56 (17.34%) died. There were statistically significant differences between ventilatory support group and no ventilatory group for suicidal intention, sex, comorbid psychiatric conditions, route of exposure, certain clinical features on admission, GCS score, POP scale, time from exposure to initiation of treatment, plasma pseudocholinesterase levels, oxygen saturation, and random blood sugar levels (p<0.05).Conclusions: OP poisoning is a life-threatening condition which requires immediate management. Early initiation of decontamination, atropine and pralidoxime therapy, with supportive ICU care, can save lives. Different demographic, exposure related parameters; some of the clinical features, treatment variables and certain laboratory findings can provide useful prognostic information and help to predict outcomes. A measures to control unchecked availability of these compounds and early transfer of victims to health care facility is needed to save many lives.
A comparative study of family burden and quality of life between caregivers of schizophrenia and dementia patients
Authors: Swain Sarada Prasanna , Behura Sushree Sangita , Dash Manoj Kumar 
Published: May 2017

Background: In chronic mental diseases, as the disease progresses, it carries with tremendous burden both physically and psychologically on the family members, who are usually in the process of caregiving. The quality of life (QOL) of these caregivers is directly related to the subjective and objective burden of the illness. The objective of the study was to assess and compare the level of family burden and QOL between caregivers of Schizophrenia and Dementia patients as well as to find out the relationship between family burden and QOL.Methods: A total of 128 key caregivers (64 caregivers of each group) fulfilling the inclusion criteria purposely selected from the OPD of MHI, S. C. B. Medical College and Neuropsychiatric Consultation Centre, Cuttack. The impact of family burden on key caregivers of dementia and schizophrenia patients was assessed by using family burden interview schedule and the quality of life of key caregivers was assessed by using WHOQOL BREF scale. Data was analysed by using chi-squre, t test and pearson correlation. Data analysis was performed by SPSS.Results: Statistical significant differences (p <0.05) were found in the areas of financial burden, disruptions of family routine activities, family leisure and family interaction between dementia and schizophrenia caregivers. Whereas there was no statistical significant difference (p >0.05) found in different domains of quality of life between these two groups of caregivers. There were significant negative correlations found between family burden and psychological, social relationships and environment domains of quality of life.Conclusions: Caregivers perceived subjective and objective burden ultimately affecting their QOL.
Prevalence and risk factors of urinary incontinence during antenatal period in women delivering in a tertiary care center of Northern India
Authors: Priya Bhanu , Singh Nilanchali , Rajaram Shalini 
Published: May 2017

Background: Urinary incontinence (UI) is a commonly encountered entity in antenatal and postpartum period. It is known to have detrimental effects on quality of life in approximately 54.3% of all pregnant women. However, the true prevalence of UI is still not known, especially in the South East Asia. This study has investigated the prevalence and risk factors of urinary incontinence during antenatal period.Methods: 500 women admitted in postnatal ward were interviewed retrospectively about the UI occurred during antenatal period, using questionnaire. The study was done over a period of six months. Detailed information regarding risk factors of urinary incontinence was included in questionnaire based on previous validated studies. Data was analyzed using SPSS 20 using chi square test. P value <0.05 was taken as significant.Results: Total 500 women were interviewed and based on questionnaire. 202 reported incontinence, thus giving a prevalence of 40.4%, out of that 192 (45.5%) had stress urinary incontinence (SUI), 40(19.8%) had urge urinary incontinence (UUI) and 70 (34.6%) had mixed incontinence. The risk factors like bladder infections and chronic cough had significant association with urinary incontinence. Advancing gestation had worsening effects on the symptoms of UI (p =0.000).Conclusions: Urinary incontinence is a common and neglected problem with poor treatment seeking behavior. SUI is more common in pregnant women than urge or mixed incontinence. Obstetricians need to ask have precise interrogation regarding UI in pregnant women to diagnose and treat the problem.
Comparative evaluation of adverse drug reactions in patients of acne prescribed with either topical benzyl peroxide or retinoic acid in a tertiary care teaching hospital
Authors: Pandya Ishan , Pandya Purna , Pethani Neha , Shah Rima Bharatbhai 
Published: May 2017

<p class="abstract"><strong>Background:</strong> To evaluate and compare the profile of adverse drug reaction, its causality, severity and preventability in patients of acne prescribed with either topical benzyl peroxide or topical retinoic acid in a tertiary care teaching hospital.</p><p class="abstract"><strong>Methods:</strong> Two hundred patients attending to dermatology department with acne and prescribed with either topical benzyl peroxide or topical retinoic acid were observed for occurrence of adverse drug events (ADEs). ADEs were either spontaneously reported or elucidated from personal interviews and analyzed.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of total 200 patients, 110 (55%) were given benzoyl peroxide gel (2.5%) and remaining 90 (45%) were given retinoic acid cream (0.025%). Total 54 adverse events were reported in 47 (23.5%) patients. Highest number of patients having ADR was from 16-20 years (35, 74.46%) with male predominance (59.57%). Number of adverse events reported was significantly higher (p &lt;0.05) in retinoic acid group (34, 62.96%) as compare to benzyl peroxide group (20, 37.03%). Most common ADRs were exfoliation (14, 25.92%) and burning sensation (13, 24.07%). Most of the ADRs fell in category of ‘probable’ and ‘possible’ in causality assessment by both WHO-UMC method and Narenjo’s scale. All the ADRs were of mild (44, 81.48%) and moderate (10, 18.52%) severity. Majority of ADRs were not preventable (24, 44.44%) followed by definitely preventable 22(40.74%) and 8 (14.81%) probably preventable.</p><p><strong>Conclusions:</strong> ADRs is a common problem associated with topically used medications for acne and its occurrence is significantly higher with retinoic acid as compare to benzyl peroxide. Early diagnosis and proper education about use of topical drugs can prevent some of the ADRs. </p>
ANALISIS KETERKAITAN SEKTOR PERTANIAN DAN PENGARUHNYA TERHADAP PEREKONOMIAN INDONESIA (ANALISIS INPUT OUPUT)
Authors: Widyawati Retno Febriyastuti 
Published: May 2017

Abstrak: Analisis Keterkaitan Sektor Pertanian dan Pengaruhnya Terhadap Perekonomian di Indonesia (Analisis Input Output). Sektor pertanian masih menjadi andalan penciptaan lapangan pekerjaan dalam jumlah yang cukup besar dibandingkan dengan sektor-sektor lainnya dalam perekonomian di Indonesia. Hal ini menjadikan peluang sektor pertanian dalam pengaruhnya terhadap perekonomian di Indonesia. Artikel ini bertujuan untuk meneliti keterkaitan ke depan dan ke belakang sektor pertanian dengan sektor-sektor lain di Indonesia dan meneliti dampak dari angka pengganda sektor pertanian. Analisis yaitu Input-Output dengan data sekunder Input-Output Indonesia 2010. Hasil menunjukkan bahwa sektor industri pengolahan dan sektor listrik, gas, air bersih memiliki keterkaitan ke depan terhadap sektor pertanian. Selanjutnya, sektor listrik, gas, air bersih; dan sektor bangunan memiliki keterkaitan ke belakang terhadap sektor pertanian. Hasil pengganda output sektor pertanian memiliki dampak pengganda output yang lebih rendah dibandingkan sektor lainnya, sedangkan pengganda pendapatan rumah tangga dan kesempatan kerja memiliki dampak pengganda yang lebih besar dibandingkan sektor lainnya. Kata Kunci: Pertanian, Input-Output, Keterkaitan, Angka Pengganda Abstract: Linkage Analysis of Agricultural Sector and Effect on the Economy in Indonesia (Input-Output Analysis). The agricultural sector is still the mainstay of job creation in large enough quantities compared to other sectors of the economy in Indonesia. It makes the chances of the agricultural sector in its influence on the economy in Indonesia. This article aims to examine the relationship forward and backward linkages agricultural sector with other sectors in Indonesia and examines the impact of multiplier output agriculture sector on the economy. Analysis use Input-Output with secondary data Input-Output Indonesia 2010. The results showed that the manufacturing sector and electricity, gas, water sector had been linked to the future of the agricultural sector. Furthermore, electricity, gas, water sector; and the building sector have backward linkages to the agriculture sector. The multiplier output agricultural sector has multiplier output impact lower than other sectors in the economy. Multiplier household income and employment agriculture have a greater multiplier effect than other sectors. Keywords: Agriculture, Input-Output, Linkages, Multiplier Effect
Значення кишкової метаплазії та дисплазії у морфологічній діагностиці хворих на хронічний рефлюкс-гастрит
Authors: Stepanov Yu.M. , Kovalenko О.М. , Oshmyanska N.Yu. 
Published: May 2017

У роботі за допомогою сучасних гістологічних, гістохімічних і морфометричних методів дослідження проаналізовано біоптати 120 хворих на хронічний рефлюкс-гастрит. Під час гістологічного дослідження слизової оболонки шлунка атрофічні процеси спостерігалися у 73,3 % випадків, при цьо­му у 46,7 % до атрофії приєднувалися більш глибокі ураження: кишкова метаплазія та гіперплазія, а у 15 % випадків — дисплазія шлункових залоз. Авторами запропоновано використання інтегрального показника «кишкова метаплазія + дисплазія» як додаткового критерію оцінки тяжкості передракових змін слизової оболонки шлунка у хворих на хронічний рефлюкс-гастрит, вірогідно пов’язаного з гіперплазією шлункових залоз, інфекцією H.руlori, підвищенням рівня нітритів і тенденцією до збільшення рівня нітратів і гастрину.
Метаболічна терапія в комплексному лікуванні пацієнтів із коморбідністю хронічного панкреатиту та стабільної ішемічної хвороби серця
Authors: Babinets L.S. , Melnyk N.A. 
Published: May 2017

Метаболічна терапія — це один із небагатьох способів відновлення нормальної роботи всіх життєво важливих органів і систем. Метою роботи було дослідити ефективність курсового лікування метаболічним препаратом Вазонат (мельдонію дигідрат) щодо корекції прооксидантно-антиоксидантних та трофологічних порушень у хворих із коморбідним перебігом хронічного панкреатиту (ХП) та стабільної ішемічної хвороби серця (СІХС). У дослідження було включено 90 пацієнтів із ХП у поєднанні із СІХС, яких було поділено на дві групи (залежно від програм лікування): І група (45 хворих) отримувала загальноприй­няте лікування; ІІ група (45 хворих) окрім загальноприйнятого лікування додатково отримувала препарат Вазонат за такою схемою: по 5 мл в/в струминно 1 раз на день протягом 10 днів з подальшим прийомом по 1 капсулі (250 мг) 2 рази на день протягом одного місяця. Було доведено, що додавання до комплексної терапії хворих із коморбідністю ХП та СІХС препарату Вазонат більшою мірою сприяє покращенню показників трофологічного та прооксидантно-антиоксидантного статусу, ніж стандартна базисна терапія.
KAJIAN MIMESIS REFLEKSI DAN REFRAKSI REALITAS IMAJINATIF DAN REALITAS OBJEKTIF NOVEL WARISAN CHAIRUL HARUN
Authors: Darussalam Zulfardi 
Published: May 2017

<p><em>This research used to use nimesis approach with descriptive qualitative method wich described the social phenomena in a novel. These phenomena are (1) the illegal sex intercourse, (2) the divorcement (3) the system of patrimony sharing, and (4) the family relationship. The data are consist of the imaginative reality data which came from Warisan, a novel by Charul Harun, (2) the objective reality which are obtained from 30 teachers of secondaries schools (SLTA dan SLTP) in Bukttinggi. Both of these data were analysed and compared. The finding show that the imaginative reality is the reflection and refraction of the objective reality. As the conclusion, Warisan was a reflection of social problems which found in the society. </em></p>