bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intrinsic random functions for mitigation of atmospheric effects in terrestrial radar interferometry
Authors: Butt Jemil , Wieser Andreas , Conzett Stefan 
Published: March 2017

Abstract
The benefits of terrestrial radar interferometry (TRI) for deformation monitoring are restricted by the influence of changing meteorological conditions contaminating the potentially highly precise measurements with spurious deformations. This is especially the case when the measurement setup includes long distances between instrument and objects of interest and the topography affecting atmospheric refraction is complex. These situations are typically encountered with geo-monitoring in mountainous regions, e.g. with glaciers, landslides or volcanoes.
We propose and explain an approach for the mitigation of atmospheric influences based on the theory of intrinsic random functions of order k (IRF-k) generalizing existing approaches based on ordinary least squares estimation of trend functions. This class of random functions retains convenient computational properties allowing for rigorous statistical inference while still permitting to model stochastic spatial phenomena which are non-stationary in mean and variance. We explore the correspondence between the properties of the IRF-k and the properties of the measurement process. In an exemplary case study, we find that our method reduces the time needed to obtain reliable estimates of glacial movements from 12 h down to 0.5 h compared to simple temporal averaging procedures.
Herbal and dietary supplements related to diarrhea and acute kidney injury: a case report
Authors: Wanitsriphinyo Suphamat , Tangkiatkumjai Mayuree 
Published: March 2017

Abstract

Background
There is very little evidence relating to the association of herbal medicine with diarrhea and the development of acute kidney injury (AKI). This study reports a case of diarrhea-induced AKI, possibly related to an individual ingesting copious amounts of homemade mixed fruit and herb puree.

Case presentation
A 45-year-old Thai man with diabetes had diarrhea for 2 days, as a result of taking high amounts of a puree made up of eight mixed fruits and herbs over a 3-day period. He developed dehydration and stage 2 AKI, with a doubling of his serum creatinine. He had been receiving enalapril, as a prescribed medication, over one year. After he stopped taking both the puree and enalapril, and received fluid replacement therapy, within a week his serum creatinine had gradually decreased. The combination of puree, enalapril and AKI may also have induced hyperkalemia in this patient. Furthermore, the patient developed hyperphosphatemia due to his worsening kidney function, exacerbated by regularly taking some dietary supplements containing high levels of phosphate. His serum levels of potassium and phosphate returned to normal within a week, once the patient stopped both the puree and all dietary supplements, and had begun receiving treatment for hyperkalemia.

Results
The mixed fruit and herb puree taken by this man may have led to his diarrhea due to its effect; particularly if the patient was taking a high concentration of such a drink. Both the puree and enalapril are likely to attenuate the progression of kidney function. The causal relationship between the puree and AKI was probable (5 scores) assessed by the modified Naranjo algorithm. This is the first case report, as far as the authors are aware, relating the drinking of a mixed fruit and herbal puree to diarrhea and AKI in a patient with diabetes.

Conclusions
This case can alert health care providers to the possibility that herbal medicine could induce diarrhea and develop acute kidney injury.
The hybrid power mean of quartic Gauss sums and Kloosterman sums
Authors: Xiaoxue Li , Jiayuan Hu 
Published: March 2017

Abstract
The main purpose of this paper is using the analytic method and the properties of the classical Gauss sums to study the computational problem of one kind fourth hybrid power mean of the quartic Gauss sums and Kloosterman sums, and give an exact computational formula for it.
Relationship between dissolved organic carbon and bacterial community in the coastal waters of Incheon, Korea
Authors: Wang Pengbin , Joo Jae-Hyoung , Park Bum Soo , Kim Joo-Hwan , Kim Jin Ho , Han Myung-Soo 
Published: March 2017

Abstract
Bacteria constitute a large domain of prokaryotic microorganisms present in marine ecosystems and play a significant role in energy flow and nutrient cycling. Bacterial community changes may affect organisms of higher trophic levels. We conducted field monitoring to study the relationship between dissolved organic carbon (DOC) and the bacterial community in the coastal waters of Incheon, Korea. Results showed that abiotic factors, such as temperature, salinity, dissolved oxygen (DO), pH, and dissolved inorganic nutrients, were not significantly different among the sampling sites during the study period. On the other hand, nutrient conditions were significantly different among the sites between 2012-2013 and 2014. Nitrogen was the limiting factor from 2012 to 2013, and phosphate in 2014. Biotic data showed that DOC affected both bacterial abundance and bacterial composition. A similar fluctuation pattern was observed for phytoplankton and Chlorophyll a. However, a close correlation was not observed between phytoplankton and other variables. Redundancy analysis (RDA) and Pearson correlation analysis of abiotic and biotic factors also showed that DOC concentration and bacterial abundance were correlated. Therefore, DOC appears to be an important factor affecting bacterial abundance and composition in the coastal waters of Incheon, Korea.
First record of the North American amphipod Melita nitida Smith, 1873 in Polish coastal waters
Authors: Normant-Saremba Monika , Marszewska Lena , Kerckhof Francis 
Published: March 2017

Abstract
The present paper reports the first observation of the North American amphipod Melita nitida Smith, 1873 in the Gulf of Gdańsk (the southern Baltic Sea, Poland). In 2014, 13 adult specimens, including 3 males, were collected in the Port of Gdynia, which is located in the western part of this waterbody.
Light-controlled spin-state-switching rearrangements of transition metal complexes with photochromic ligands
Authors: Minkin Vladimir I. , Starikov Andrey G. , Starikova Alyona A. 
Published: March 2017

Abstract
New families of the transition metal complexes with photochromic ligands manifesting photoswitchable magnetic properties determined by the light-induced spin-crossover and configurational isomerization rearrangements are theoretically designed by means of DFT calculations of electromeric forms of the complexes.
Antistatic surface properties of plastics using donor-accepter molecular compounding antistatic agent
Authors: Watanabe Takuro , Hamanaka Hiroyoshi , Sano Tomomi , Ito Hiroshi 
Published: March 2017

Abstract
In order to obtain transparent plastic material with antistatic property for optical communication application, cyclo olefin polymer (COP)/BN105 composite materials prepared by using injection molding have been evaluated. Surface resistance of the molded product decreased to 2×1011 Ω/sq along with an increase in BN105 content range up to 2 wt%. The samples showed excellent property to prevent the surface from dust adhesion. In addition, the samples containing BN105 less than 5 wt% did not show any decrease in transmittance without any significant change of tensile strength. The results indicate COP/BN105 as a promising plastic composite material with sufficient antistatic property as well as high transparency.
Bemerkungen zu Ostrakon Clermont-Ganneau J8 (175+185) aus Elephantine
Authors: Grassi Giulia Francesca 
Published: March 2017

ZusammenfassungDieser Aufsatz beschäftigt sich mit einem aramäischen Text der Perserzeit (5. Jh. v. Chr.), der bei den französischen Grabungen auf der Nilinsel Elephantine im Jahr 1908 gefunden wurde. In diesem Ostrakon, das leider unvollständig ist, erscheint der Gottesname Jahweh Ṣaba ʾôt (
The Cruel Theology of Ezekiel 20
Authors: Kugler Gili 
Published: March 2017

AbstractReaders and commentators throughout the generations engaged with the disturbing statement in the book of Ezekiel, claiming that God gave Israel »statutes that were not good and ordinances by which they could not live« (20:25). Since this statement might have undervalued, as argued in early Christian commentaries, the worth of Jewish rituals, Ezekiel’s words were obscured or narrowed down in later Jewish interpretations. Modern commentators brought the verse back into consideration, indicating the intentions of God to hurt the people as understood from the verse within its context. Nevertheless some of the commentators kept reducing the radical implications of the statement by minimizing it into one specific law or assigning it to a speaker other than God. This article suggests a way to read the statement literarily in view of the historical retrospective in which it is embedded. This historical retrospective involves two contradictory approaches regarding the divine retribution paradigm, making God’s imposition of evil laws upon his people not only plausible but necessary.
Neuronify: An Educational Simulator for Neural Circuits
Authors: Dragly Svenn-Arne , Hobbi Mobarhan Milad , Våvang Solbrå Andreas , Tennøe Simen , Hafreager Anders , Malthe-Sørenssen Anders , Fyhn Marianne , Hafting Torkel , Einevoll Gaute T. 
Published: March 2017

AbstractEducational software (apps) can improve science education by providing an interactive way of learning about complicated topics that are hard to explain with text and static illustrations. However, few educational apps are available for simulation of neural networks. Here, we describe an educational app, Neuronify, allowing the user to easily create and explore neural networks in a plug-and-play simulation environment. The user can pick network elements with adjustable parameters from a menu, i.e., synaptically connected neurons modelled as integrate-and-fire neurons and various stimulators (current sources, spike generators, visual, and touch) and recording devices (voltmeter, spike detector, and loudspeaker). We aim to provide a low entry point to simulation-based neuroscience by allowing students with no programming experience to create and simulate neural networks. To facilitate the use of Neuronify in teaching, a set of premade common network motifs is provided, performing functions such as input summation, gain control by inhibition, and detection of direction of stimulus movement. Neuronify is developed in C++ and QML using the cross-platform application framework Qt and runs on smart phones (Android, iOS) and tablet computers as well personal computers (Windows, Mac, Linux).
Static Magnetic Field Stimulation over Parietal Cortex Enhances Somatosensory Detection in Humans
Authors: Carrasco-López Carmen , Soto-León Vanesa , Céspedes Virginia , Profice Paolo , Strange Bryan A. , Foffani Guglielmo , Oliviero Antonio 
Published: March 2017

The role of neuronal oscillations in human somatosensory perception is currently unclear. To address this, here we use noninvasive brain stimulation to artificially modulate cortical network dynamics in the context of neurophysiological and behavioral recordings. We demonstrate that transcranial static magnetic field stimulation (tSMS) over the somatosensory parietal cortex increases oscillatory power specifically in the alpha range, without significantly affecting bottom-up thalamocortical inputs indexed by the early cortical component of somatosensory evoked potentials. Critically, we next show that parietal tSMS enhances the detection of near-threshold somatosensory stimuli. Interestingly, this behavioral improvement reflects a decrease of habituation to somatosensation. Our data therefore provide causal evidence that somatosensory perception depends on parietal alpha activity.SIGNIFICANCE STATEMENTArtificially increasing alpha power by placing a powerful magnetic field over the somatosensory cortex overcomes the natural decline in detection probability of a repeated near-threshold sensory stimulus.
AKT‐phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1‐MAPK interaction
Authors: Pan Chun‐Wu , Jin Xin , Zhao Yu , Pan Yunqian , Yang Jing , Karnes R Jeffrey , Zhang Jun , Wang Liguo , Huang Haojie 
Published: March 2017

AbstractNuclear FOXO proteins act as tumor suppressors by transcriptionally activating genes involved in apoptosis and cell cycle arrest, and these anticancer functions are inhibited by AKT‐induced phosphorylation and cytoplasmic sequestration of FOXOs. We found that, after AKT‐mediated phosphorylation at serine 319, FOXO1 binds to IQGAP1, a hub for activation of the MAPK pathway, and impedes IQGAP1‐dependent phosphorylation of ERK1/2 (pERK1/2). Conversely, decreased FOXO1 expression increases pERK1/2 in cancer cell lines and correlates with increased pERK1/2 levels in patient specimens and disease progression. Treatment of cancer cells with PI3K inhibitors or taxane causes FOXO1 localization in the nucleus, increased expression of pERK1/2, and drug resistance. These effects are reversed by administering a small FOXO1‐derived phospho‐mimicking peptide inhibitor in vitro and in mice. Our results show a tumor suppressor role of AKT‐phosphorylated FOXO1 in the cytoplasm and suggest that this function of FOXO1 can be harnessed to overcome chemoresistance in cancer.
Persistency of Prediction Accuracy and Genetic Gain in Synthetic Populations Under Recurrent Genomic Selection
Authors: Müller Dominik , Schopp Pascal , Melchinger Albrecht E 
Published: March 2017

AbstractRecurrent selection (RS) has been used in plant breeding to successively improve synthetic and other multiparental populations. Synthetics are generated from a limited number of parents (Np), but little is known about how Np affects genomic selection (GS) in RS, especially the persistency of prediction accuracy (rg,g^) and genetic gain. Synthetics were simulated by intermating Np= 2–32 parent lines from an ancestral population with short- or long-range linkage disequilibrium (LDA) and subjected to multiple cycles of GS. We determined rg,g^ and genetic gain across 30 cycles for different training set (TS) sizes, marker densities, and generations of recombination before model training. Contributions to rg,g^ and genetic gain from pedigree relationships, as well as from cosegregation and LDA between QTL and markers, were analyzed via four scenarios differing in (i) the relatedness between TS and selection candidates and (ii) whether selection was based on markers or pedigree records. Persistency of rg,g^ was high for small Np, where predominantly cosegregation contributed to rg,g^, but also for large Np, where LDA replaced cosegregation as the dominant information source. Together with increasing genetic variance, this compensation resulted in relatively constant long- and short-term genetic gain for increasing Np &gt; 4, given long-range LDA in the ancestral population. Although our scenarios suggest that information from pedigree relationships contributed to rg,g^ for only very few generations in GS, we expect a longer contribution than in pedigree BLUP, because capturing Mendelian sampling by markers reduces selective pressure on pedigree relationships. Larger TS size (NTS) and higher marker density improved persistency of rg,g^ and hence genetic gain, but additional recombinations could not increase genetic gain.
Cytoplasmic–Nuclear Incompatibility Between Wild Isolates ofCaenorhabditis nouraguensis
Authors: Lamelza Piero , Ailion Michael 
Published: March 2017

AbstractHow species arise is a fundamental question in biology. Species can be defined as populations of interbreeding individuals that are reproductively isolated from other such populations. Therefore, understanding how reproductive barriers evolve between populations is essential for understanding the process of speciation. Hybrid incompatibility (for example, hybrid sterility or lethality) is a common and strong reproductive barrier in nature. Here we report a lethal incompatibility between two wild isolates of the nematode Caenorhabditis nouraguensis. Hybrid inviability results from the incompatibility between a maternally inherited cytoplasmic factor from each strain and a recessive nuclear locus from the other. We have excluded the possibility that maternally inherited endosymbiotic bacteria cause the incompatibility by treating both strains with tetracycline and show that hybrid death is unaffected. Furthermore, cytoplasmic–nuclear incompatibility commonly occurs between other wild isolates, indicating that this is a significant reproductive barrier within C. nouraguensis. We hypothesize that the maternally inherited cytoplasmic factor is the mitochondrial genome and that mitochondrial dysfunction underlies hybrid death. This system has the potential to shed light on the dynamics of divergent mitochondrial–nuclear coevolution and its role in promoting speciation.
Reliable CRISPR/Cas9 Genome Engineering inCaenorhabditis elegansUsing a Single Efficient sgRNA and an Easily Recognizable Phenotype
Authors: El Mouridi Sonia , Lecroisey Claire , Tardy Philippe , Mercier Marine , Leclercq-Blondel Alice , Zariohi Nora , Boulin Thomas 
Published: March 2017

AbstractCRISPR/Cas9 genome engineering strategies allow the directed modification of the Caenorhabditis elegans genome to introduce point mutations, generate knock-out mutants, and insert coding sequences for epitope or fluorescent tags. Three practical aspects, however, complicate such experiments. First, the efficiency and specificity of single-guide RNAs (sgRNA) cannot be reliably predicted. Second, the detection of animals carrying genome edits can be challenging in the absence of clearly visible or selectable phenotypes. Third, the sgRNA target site must be inactivated after editing to avoid further double-strand break events. We describe here a strategy that addresses these complications by transplanting the protospacer of a highly efficient sgRNA into a gene of interest to render it amenable to genome engineering. This sgRNA targeting the dpy-10 gene generates genome edits at comparatively high frequency. We demonstrate that the transplanted protospacer is cleaved at the same time as the dpy-10 gene. Our strategy generates scarless genome edits because it no longer requires the introduction of mutations in endogenous sgRNA target sites. Modified progeny can be easily identified in the F1 generation, which drastically reduces the number of animals to be tested by PCR or phenotypic analysis. Using this strategy, we reliably generated precise deletion mutants, transcriptional reporters, and translational fusions with epitope tags and fluorescent reporter genes. In particular, we report here the first use of the new red fluorescent protein mScarlet in a multicellular organism. wrmScarlet, a C. elegans-optimized version, dramatically surpassed TagRFP-T by showing an eightfold increase in fluorescence in a direct comparison.
Comparative Analyses of Selection Operating on Nontranslated Intergenic Regions of Diverse Bacterial Species
Authors: Thorpe Harry A , Bayliss Sion C , Hurst Laurence D , Feil Edward J 
Published: March 2017

AbstractTo date, the existing very large genome sequence datasets of many bacterial species have not been exploited to quantify the strength and direction of...Nontranslated intergenic regions (IGRs) compose 10–15% of bacterial genomes, and contain many regulatory elements with key functions. Despite this, there are few systematic studies on the strength and direction of selection operating on IGRs in bacteria using whole-genome sequence data sets. Here we exploit representative whole-genome data sets from six diverse bacterial species: Staphylococcus aureus, Streptococcus pneumoniae, Mycobacterium tuberculosis, Salmonella enterica, Klebsiella pneumoniae, and Escherichia coli. We compare patterns of selection operating on IGRs using two independent methods: the proportion of singleton mutations and the dI/dS ratio, where dI is the number of intergenic SNPs per intergenic site. We find that the strength of purifying selection operating over all intergenic sites is consistently intermediate between that operating on synonymous and nonsynonymous sites. Ribosome binding sites and noncoding RNAs tend to be under stronger selective constraint than promoters and Rho-independent terminators. Strikingly, a clear signal of purifying selection remains even when all these major categories of regulatory elements are excluded, and this constraint is highest immediately upstream of genes. While a paucity of variation means that the data for M. tuberculosis are more equivocal than for the other species, we find strong evidence for positive selection within promoters of this species. This points to a key adaptive role for regulatory changes in this important pathogen. Our study underlines the feasibility and utility of gauging the selective forces operating on bacterial IGRs from whole-genome sequence data, and suggests that our current understanding of the functionality of these sequences is far from complete.
Isolasi Bakteri Pendegradasi Xilan dan Manan dari Perairan Indonesia
Authors: Tasia Winda , Zuraida Rina , Yopi Yopi 
Published: March 2017

Bakteri laut penghasil enzim xilanase dan mananase menyimpan banyak potensi bagi bioteknologi kelautan. Informasi sebarannya juga dapat digunakan untuk memetakan keragaman bakteri laut serta analisis lingkungan perairan Indonesia sehingga pemanfaatannya dapat tepat sasaran. Penelitian ini bertujuan untuk mengisolasi bakteri laut pendegradasi xilan dan manan dari Indonesia. Penapisan kemampuan xilanolitik dan manolitik menggunakan metode Congo red dilakukan pada isolat bakteri yang diisolasi dari Laut Jawa, Selat Makassar, Laut Flores, dan Laut Sawu pada kedalaman 5 dan 20 m. Hasil penelitian menunjukkan bahwa isolat X7517, X1654, dan XM26511 diketahui menghasilkan xilanase dengan kondisi optimal reaksi enzim masing-masing adalah pH 9, T 90 °C (2,253±2,075 U/ml), pH 6, T 70 °C (0,633±0,082 U/ml), dan pH 6, T 70 °C (2,293±0,066 U/ml). Ketiganya diketahui memiliki kesamaan genetis dengan Halomonas aquamarina DSM 30161, Alteromonas macleodii NBRC 102226, dan H. meridiana NBRC 15608. Isolat bakteri manolitik L15203 dan L16571 memiliki kesamaan dengan Idiomarina zobellii KMM231, sedangkan isolat L2207 memiliki kesamaan dengan Bacillus sp. MB 71. Ketiga bakteri tersebut memiliki aktivitas mananase optimal pada kondisi alkali, masing-masing pada pH 8, T 80 °C (0,477±0,024 U/ml) untuk L 15203, pH 9,T 90 °C (0,476±0,009U/ml) untuk L16571 dan pH 9, T 80 °C (0,528±0,057 U/ml) untuk L2207. Bakteri laut xilanolitik dan manolitik yang berpotensi dalam produksi xilanase dan mananase melimpah di sebagian perairan Indonesia, terutama di perairan yang semakin dekat permukaan laut atau perairan dangkal.