bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Effects of Neuromuscular Electrical Stimulation of The Lower Limbs Combined with Pulmonary Rehabilitation on Exercise Tolerance in Patients with Chronic Obstructive Pulmonary Disease
Authors: Kucio Cezary , Niesporek Justyna , Kucio Ewa , Narloch Dominika , Węgrzyn Bartosz 
Published: December 2016

Abstract
Chronic obstructive pulmonary disease (COPD) is a systemic disease with multiple extrapulmonary manifestations including impeded skeletal muscle function, leading to decreased muscular strength and endurance in patients with COPD. Pulmonary rehabilitation eases the symptoms of the condition and produces increased muscular endurance. Neuromuscular electrical stimulation (NMES) may serve as a treatment alternative to traditional pulmonary rehabilitation. The aim of the study was to assess the effects of NMES combined with pulmonary rehabilitation on exercise tolerance in patients in comparison with pulmonary rehabilitation alone. The subjects included 30 patients with COPD randomly assigned to one of the two groups. The first group consisted of 15 patients who were treated with neuromuscular electrical stimulation at frequency of 35Hz and pulmonary rehabilitation (NMES+RP). The second group comprised 15 patients treated with pulmonary rehabilitation only (RP). Pre- and poststudy assessments were performed. The retrospective evaluation including an exercise tolerance test (i.e. six minute walk test (6MWT)), spirometry and blood gasometry was carried out after 3 weeks. Twenty-eight patients in total completed the study. In the NMES+RP group, an increase in exercise tolerance manifested by a longer distance walked in the 6MWT was observed in comparison to the pulmonary rehabilitation group. No effects of NMES combined with pulmonary rehabilitation on selected spirometric and gasometric parameters in patients with COPD were observed in comparison with traditional pulmonary rehabilitation. The acquired results suggest that NMES of the lower limbs may be applied as an additional form of pulmonary rehabilitation in patients with COPD.
Effect of integrated school-based nutrition education on optimal dietary practices and nutritional status of school adolescents in Southwest of Ethiopia: a quasi-experimental study
Authors: Tamiru Dessalegn , Argaw Alemayehu , Gerbaba Mulusew , Ayana Girmay , Nigussie Aderajew , Belachew Tefera 
Published: December 2016

Abstract

Background:
Malnutrition and infection are major barriers to educational access and achievement in low-income countries and also work in conjunction with each other in deteriorating wellness and productivity of school adolescents.

Methods:
A quasi-experimental design was used to evaluate the effectiveness of school-based nutrition education using a peer-led approach, health promotion through school media and health clubs. Data were collected at baseline, midline and end line from sampled participants. To account for the effect of time trend, the difference was measured using a repeated measure analysis. Variables that have p≤0.25 in the bivariate analyses were entered into multivariables to determine the independent effect of interventions.

Results:
There is a significant difference in food variety between food secure and insecure households (p<0.01). A significant improvement of animal source dietary intake was observed among intervention schools (p<0.001) that was significantly associated with an intervention [adjusted odds ratio (AOR)=0.26, confidence interval (CI): 0.16, 0.42], male gender (AOR=0.48, CI: 0.31, 0.73) and household economic status (AOR=1.69, CI: 1.01, 2.84). The control group had high body mass index (BMI) at baseline, but a significant improvement was observed among the intervention schools, which positively associated with male gender (AOR=4.13, CI: 2.38, 7.15) and having a middle-income family (AOR=2.93, CI: 1.92, 6.15).

Conclusion:
This study showed that by integrating a dietary intervention into school-based activities, there might be significant improvements in dietary intake of primary school adolescents. Therefore, school-based nutrition education programs should be a part of comprehensive school health programs to reach the students and potentially their families.
Sensitivity and specificity of different methods for cystic fibrosis-related diabetes screening: is the oral glucose tolerance test still the standard?
Authors: Mainguy Catherine , Bellon Gabriel , Delaup Véronique , Ginoux Tiphanie , Kassai-Koupai Behrouz , Mazur Stéphane , Rabilloud Muriel , Remontet Laurent , Reix Philippe 
Published: December 2016

AbstractBackground:Cystic fibrosis-related diabetes (CFRD) is a late cystic fibrosis (CF)-associated comorbidity whose prevalence is increasing sharply lifelong. Guidelines for glucose metabolism (GM) monitoring rely on the oral glucose tolerance test (OGTT). However, this test is neither sensitive nor specific. The aim of this study was to compare sensitivity and specificity of different methods for GM monitoring in children and adolescents with CF.Methods:Continuous glucose monitoring system (CGMS), used as the reference method, was compared with the OGTT, intravenous glucose tolerance test (IGTT), homeostasis model assessment index of insulin resistance (HOMA-IR), homeostasis model assessment index of β-cell function (HOMA-%B) and glycated haemoglobin AResults:Twenty-nine patients (median age: 13.1 years) were recruited. According to CGMS, 11 had DM, 12 IGT and six NGT, whereas OGTT identified three patients with DM and five with IGT. While 13 of 27 had insulin deficiency according to IGTT, there was 19 of 28 according to HOMA-%B. According to HOMA-IR, 12 of 28 had insulin resistance. HOMA-%B was the most sensitive method for CFRD screening [sensitivity 91% (95% CI), specificity 47% (95% CI) and negative predictive value 89% (95% CI)].Conclusions:OGTT showed the weak capacity to diagnose DM in CF and should no longer be considered as the reference method for CFRD screening in patients with CF. In our study, HOMA-%B showed promising metrics for CFRD screening. Finally, CGMS revealed that pathological glucose excursions were frequent even early in life.
Usefulness of non-fasting lipid parameters in children
Authors: Kubo Toshihide , Takahashi Kyohei , Furujo Mahoko , Hyodo Yuki , Tsuchiya Hiroki , Hattori Mariko , Fujinaga Shoko , Urayama Kenji 
Published: December 2016

AbstractBackground:This study assessed whether non-fasting lipid markers could be substituted for fasting markers in screening for dyslipidemia, whether direct measurement of non-fasting low-density lipoprotein cholesterol [LDL-C (D)] could be substituted for the calculation of fasting LDL-C [LDL-C (F)], and the utility of measuring non-high-density lipoprotein cholesterol (non-HDL-C).Methods:In 33 children, the lipid profile was measured in the non-fasting and fasting states within 24 h. Correlations were examined between non-fasting LDL-C (D) or non-HDL-C levels and fasting LDL-C (F) levels.Results:Non-fasting triglyceride (TG), total cholesterol (TC), HDL-C, LDL-C (D), and non-HDL-C levels were all significantly higher than the fasting levels, but the mean difference was within 10% (except for TG). Non-fasting LDL-C (D) and non-HDL-C levels were strongly correlated with the fasting LDL-C (F) levels.Conclusions:In conclusion, except for TG, non-fasting lipid parameters are useful when screening children for dyslipidemia. Direct measurement of non-fasting LDL-C and calculation of non-fasting non-HDL-C could replace the calculation of fasting LDL-C because of convenience.
YKL-40 expression in abnormal invasive placenta cases
Authors: Gözükara İlay , Özgür Tümay , Dolapçıoğlu Kenan , Güngören Arif , Karapınar Oya Soylu 
Published: December 2016

AbstractObjective:YKL-40 is a secreted glycoprotein and has been implicated in the proliferation and differentiation of malignant cells, extracellular tissue remodelling, neovascularisation, inhibition of cancer cell apoptosis and stimulation of tumour-associated fibroblasts. The purpose of this study was to evaluate YKL-40 tissue expression in extravillous trophoblast invasion and its possible implication in placenta creta.Methods:A total of 35 placenta creta cases and six control cases were included in the study, of which eight cases were placenta accreta, 12 were increta and 15 were percreta. Histological YKL-40 staining was scored in tissue as weak (1), medium (2) and strong (3).Results:YKL-40 immunoreactivity intensity in the percreta group was significantly higher compared to the increta and accreta groups (2.47±0.74, 1.33±0.49 and 1.37±0.52, respectively; P=0.000). YKL-40 immunoreactivity intensity was positively correlated with creta (r=0.6; P=0.000), depth of invasion (r=0.49; P=0.003) and depth of invasion to full thickness ratio (r=0.58; P=0.000).Conclusion:This study demonstrated that YKL-40 is strongly expressed in placenta percreta and is correlated with extravillous trophoblast invasion. These findings may be informative for understanding the pathophysiology of placenta creta.
α-Synuclein lipoprotein nanoparticles
Authors: Eichmann Cédric , Bibow Stefan , Riek Roland 
Published: December 2016

AbstractApolipoprotein nanodiscs are a versatile tool in nanotechnology as membrane mimetics allowing, for example, the study of membrane proteins. It has recently been discovered that the Parkinson’s disease associated protein α-synuclein (α-Syn) can also form discoid-like lipoprotein nanoparticles. The present review highlights the observation that α-Syn has the properties to define stable and homogeneous populations of nanoparticles with diameters of 7–10 nm and 19–28 nm by modifying lipid vesicles or encapsulating lipid bilayers in a nanodisc-type fashion, respectively. In contrast to apolipoprotein nanodiscs, α-Syn nanoparticles can incorporate entirely negatively charged lipids emphasizing their potential use in nanotechnology as a negatively charged membrane mimetic.
Comparison of selected methods used in the assessment of contamination with heavy metals in littoral sediments of lakes
Authors: Dunalska Julita A. , Gusiatin Zygmunt M. , Zieliński Rafał , Szymański Daniel , Sieńska Justyna 
Published: December 2016

Abstract
This study compared selected methods of assessing the pollution in the littoral sediments by heavy metals (Zn, Cu, Pb, Ni and Cd) in 13 lakes of the Borecka Forest. For this purpose, the ecotoxicological criteria (PEL TEL), the geoaccumulation index (Igeo), the contamination factor (CF) and the contamination degree (Cd) were applied. Characteristic values for both Poland (GBP) and the Earth’s crust (GBE) were assumed as the geochemical background. In addition, the organic (TOC) and inorganic (TIC) carbon were determined in the analyzed sediments. Regardless of the method or adopted background value, the highest pollution level was in the littoral sediments of Lake Szwałk Mały and Lake Kacze. This was primarily associated with increased concentrations of Cd (1.25 and 0.64 mg kg−1, respectively), which was considered as “likely to have toxic effects on organisms” (exceeding PEL). Several potential sources of this metal (fertilizers, herbicides, leaky septic tanks, bait fishing, drainage ditches, allochthonous organic matter) were identified. The content of heavy metals in the littoral sediments of other lakes was sufficiently low and they could be considered as basically uncontaminated.
Ecological patterns of water bug (Hemiptera: Heteroptera) assemblages in karst springs: a case study from central Montenegro
Authors: Gligorović Bogić , Savić Ana , Protić Ljiljana , Pešić Vladimir 
Published: December 2016

Abstract
The composition of water bug communities from 32 springs located in the central part of Montenegro was investigated. Twenty five species were identified, including 13 reported as new to Montenegro. The most common species were Hydrometra stagnorum and Velia sp. (Gerromorpha). Our study in the central part of Montenegro revealed that environmental and faunistic classification of karstic springs based on water bug communities may not correspond with each other. According to environmental characteristics, springs were divided into three groups indicating anthropogenic impact on the spring habitats. Water bug communities divided springs into four groups. There are differences in species richness between these four types of water bug assemblages and among the studied spring types. Results of CCA analysis revealed spring size as the main driver of biotic diversity of aquatic bugs in springs. Our study showed that community groups of water bugs specified in the biotic classification of spring habitats are much better defined than assemblages distinguished in the environmental site classification.
Is the body condition of the three-spined stickleback (Gasterosteus aculeatus) determined by the type of food consumed?
Authors: Pawelec Anna J. , Sapota Mariusz R. , Skóra Michał E. 
Published: December 2016

Abstract
The three spine stickleback Gasterosteus aculeatus is a small omnivorous, wildly distributed fish. In this study, food uptake and body condition of three spine stickleback, from the Gulf of Gdansk eulitoral was investigated. Samples were taken from three locations of the Gulf of Gdańsk: in vicinities of Sopot, Chałupy and Hel. Copepods were the most quantitive food components in the three spine stickleback stomachs. In spring, at Hel station -Harpacticoida and in Sopot, crustacean and fish eggs, were dominating as a fish prey. During summer, Calanoida were most abundant in stomachs collected from fish caught in Chałupy, fish eggs and Calanoida in those from Hel station. In stomachs of fish from Sopot location most common prey were Cladocera. Comparison of stomach content to food base and Fulton’s body condition index revealed that the three spine stickleback uses available food base in efficient way.
Occurrence of the parasite Prosorhynchus squamatus (Digenea) in mussels Mytilus trossulus from the Gulf of Gdańsk (the southern Baltic Sea)
Authors: Rolbiecki Leszek , Wołowicz Maciej , Dołęga Małgorzata 
Published: December 2016

Abstract
Sporocysts with cercariae of Prosorhynchus squamatus Odhner, 1905 (Digenea, Bucephalidae) have been found for the first time in mussels Mytilus trossulus Gould, 1850 from the Gulf of Gdańsk (the southern Baltic Sea). The presented work provides a description and morphometry of larvae of this parasite.
Comb-like copolymer dispersant for PP/CaCO3 composites: effects of particle concentration on properties of composites
Authors: Jing Xiwei , Gong Weiguang , Feng Zhongjun , Meng Xin , Zheng Baicun 
Published: December 2016

Abstract
A comb-like copolymer poly (styrene-co-maleic anhydride)-graft-poly (ε-caprolacton) (SMA-g-PCL, SP) with carboxyl group as an anchoring group and polycaprolactone as a solvent chain was used as an effective dispersant for CaCO3 in the polypropylene (PP) matrix. The effects of CaCO3 concentration on crystallization behaviors, mechanical properties, and thermal stabilities were studied systematically. The results revealed that the dispersion of CaCO3 in the PP matrix was markedly improved owing to the steric hindrance effect caused by PCL, and the SP-coated CaCO3 was a very effective nucleating agent for PP. Proper CaCO3 concentration corresponded to the improvement of crystallization temperature, crystallinity, and crystallization rate of PP. There was only a slight improvement in yield stress but great improvement in Young’s modulus, flexural modulus, and impact strength. However, the excessive CaCO3 filler deteriorated the mechanical properties. The good dispersion of SP-coated CaCO3 in the PP matrix also accounted for the improvement of thermal stability. The initial decomposition temperature of the PP/CaCO3 composite with 7.4 wt.% CaCO3 increased 35°C compared with neat PP.
How did Anaximander Become a Material Monist?
Authors: Carraro Nicola 
Published: December 2016

AbstractAlthough the view that Anaximander was a Material Monist is not very popular nowadays, it is still widely held that it was embraced by Aristotle at least on some occasions, then adopted by Theophrastus, and later on inherited by Simplicius, our main source on the Presocratics. I argue that none of these three philosophers held this view and that, for this reason, it should not be seen as the standard ancient interpretation of Anaximander.
Platonic Astronomy and the Development of Ancient Sphairopoiia
Authors: Kalligas Paul 
Published: December 2016

AbstractPlato’s views on astronomy are still somehow debated, however various scholars have associated his name with the project of “saving the appearances”, which is thought to have aimed at offering a precise geometrical account of celestial motions. A passage from Theon of Smyrna’s treatise on Platonic mathematics relates this project with the construction of mechanical models of the cosmos. New information deriving from the study of the so-called Antikythera mechanism, found nearly 100 years ago in an ancient shipwreck in the Aegean, seems to provide important technical evidence illustrating the evolution of this endeavour during the Hellenistic period.
Seasonal Changes in Soccer Players' Body Composition and Dietary Intake Practices
Authors: Devlin Brooke L. , Kingsley Michael , Leveritt Michael D. , Belski Regina 
Published: December 2016

Abstract
Devlin, BL, Kingsley, M, Leveritt, MD, and Belski, R. Seasonal changes in soccer players' body composition and dietary intake practices. J Strength Cond Res 31(12): 3319–3326, 2017—The aims of this study were 2-fold: to determine seasonal changes in dietary intake and body composition in elite soccer players and to evaluate the influence of self-determined individual body composition goals on dietary intake and body composition. This longitudinal, observational study assessed body composition (total mass, fat-free soft tissue mass, and fat mass) using dual-energy x-ray absorptiometry and dietary intake (energy and macronutrients) via multiple-pass 24-hour recalls, at 4 time points over a competitive season in elite soccer players from one professional club in the Australian A-League competition. Self-reported body composition goals were also recorded. Eighteen elite male soccer players took part (25 ± 5 years, 180.5 ± 7.4 cm, 75.6 ± 6.5 kg). Majority (≥67%) reported the goal to maintain weight. Fat-free soft tissue mass increased from the start of preseason (55,278 ± 5,475 g) to the start of competitive season (56,784 ± 5,168 g; p < 0.001), and these gains were maintained until the end of the season. Fat mass decreased over the preseason period (10,072 ± 2,493 g to 8,712 ± 1,432 g; p < 0.001), but increased during the latter part of the competitive season. Dietary intake practices on training days were consistent over time and low compared with sport nutrition recommendations. The self-reported body composition goals did not strongly influence dietary intake practices or changes in body composition. This study has demonstrated that body composition changes over the course of a soccer season are subtle in elite soccer players despite relatively low self-reported intake of energy and carbohydrate.
Genetic Mechanisms Leading to Sex Differences Across Common Diseases and Anthropometric Traits
Authors: Traglia Michela , Bseiso Dina , Gusev Alexander , Adviento Brigid , Park Daniel S , Mefford Joel A , Zaitlen Noah , Weiss Lauren A 
Published: December 2016

AbstractCommon diseases often show sex differences in prevalence, onset, symptomology, treatment, or prognosis. Although studies have been performed to evaluate sex differences at specific SNP associations, this work aims to comprehensively survey a number of complex heritable diseases and anthropometric traits. Potential genetically encoded sex differences we investigated include differential genetic liability thresholds or distributions, gene–sex interaction at autosomal loci, major contribution of the X-chromosome, or gene–environment interactions reflected in genes responsive to androgens or estrogens. Finally, we tested the overlap between sex-differential association with anthropometric traits and disease risk. We utilized complementary approaches of assessing GWAS association enrichment and SNP-based heritability estimation to explore explicit sex differences, as well as enrichment in sex-implicated functional categories. We do not find consistent increased genetic load in the lower-prevalence sex, or a disproportionate role for the X-chromosome in disease risk, despite sex-heterogeneity on the X for several traits. We find that all anthropometric traits show less than complete correlation between the genetic contribution to males and females, and find a convincing example of autosome-wide genome-sex interaction in multiple sclerosis (P = 1 × 10−9). We also find some evidence for hormone-responsive gene enrichment, and striking evidence of the contribution of sex-differential anthropometric associations to common disease risk, implying that general mechanisms of sexual dimorphism determining secondary sex characteristics have shared effects on disease risk.
The Promiscuous sumA Missense Suppressor from Salmonella enterica Has an Intriguing Mechanism of Action
Authors: Cole Ashley E , Hani Fatmah M , Altman Ronni , Meservy Megan , Roth John R , Altman Elliot 
Published: December 2016

Abstract
While most missense suppressors have very narrow specificities and only suppress the allele against which they were isolated, the sumA missense suppressor from Salmonella enterica serovar Typhimurium is a promiscuous or broad-acting missense suppressor that suppresses numerous missense mutants. The sumA missense suppressor was identified as a glyV tRNA Gly3(GAU/C) missense suppressor that can recognize GAU or GAC aspartic acid codons and insert a glycine amino acid instead of aspartic acid. In addition to rescuing missense mutants caused by glycine to aspartic acid changes as expected, sumA could also rescue a number of other missense mutants as well by changing a neighboring (contacting) aspartic acid to glycine, which compensated for the other amino acid change. Thus the ability of sumA to rescue numerous missense mutants was due in part to the large number of glycine codons in genes that can be mutated to an aspartic acid codon and in part to the general tolerability and/or preference for glycine amino acids in proteins. Because the glyV tRNA Gly3(GAU/C) missense suppressor has also been extensively characterized in Escherichia coli as the mutA mutator, we demonstrated that all gain-of-function mutants isolated in a glyV tRNA Gly3(GAU/C) missense suppressor are transferable to a wild-type background and thus the increased mutation rates, which occur in glyV tRNA Gly3(GAU/C) missense suppressors, are not due to the suppression of these mutants.