bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hexaphyrin as a Potential Theranostic Dye for Photothermal Therapy and 19F Magnetic Resonance Imaging
Authors: Higashino Tomohiro , Nakatsuji Hirotaka , Fukuda Ryosuke , Okamoto Haruki , Imai Hirohiko , Matsuda Tetsuya , Tochio Hidehito , Shirakawa Masahiro , Tkachenko Nikolai V. , Hashida Mitsuru , Murakami Tatsuya , Imahori Hiroshi 
Published: February 2017

AbstractTwo features of meso‐Aryl‐substituted expanded porphyrins suggest suitability as theranostic agents. They have excellent absorption in near infrared (NIR) region, and they offer the possibility of introduction of multiple fluorine atoms at structurally equivalent positions. Here, hexaphyrin (hexa) was synthesized from 2,6‐bis(trifluoromethyl)‐4‐formyl benzoate and pyrrole and evaluated as a novel expanded porphyrin with the above features. Under NIR illumination hexa showed intense photothermal and weak photodynamic effects, which were most likely due to its low excited states, close to singlet oxygen. The sustained photothermal effect caused ablation of cancer cells more effectively than the photodynamic effect of indocyanine green (a clinical dye). In addition, hexa showed potential for use in the visualization of tumors by 19F magnetic resonance imaging (MRI), because of the multiple fluorine atoms. Our results strongly support the utility of expanded porphyrins as theranostic agents in both photothermal therapy and 19F MRI.
Influence of a critical single nucleotide polymorphism on nuclear receptor PXR‐promoter function
Authors: Rana Manjul , Coshic Poonam , Goswami Ravinder , Tyagi Rakesh K. 
Published: February 2017

AbstractThe Pregnane and Xenobiotic Receptor (PXR; NR1I2) is a ligand‐modulated transcription factor that belongs to the nuclear receptor superfamily. It is expressed at higher levels primarily in liver and intestine as compared to the levels in several other organs. It is activated by a broad spectrum of xenobiotics and endobiotics. The primary function of PXR is to regulate the expression of drug metabolizing enzymes and transporters and prevent the accumulation of toxic chemicals in the body, thereby maintaining body's homeostasis. In this study, we identified a C/T single nucleotide polymorphism at position −831 from the transcriptional start site of the PXR gene promoter and examined the functional significance of this variant using both the luciferase reporter gene assays and electrophoretic mobility shift assays (EMSA). Transient transfection experiments showed that the T‐allele was associated with significantly greater transcriptional activity than the C‐allele of SNP rs3814055. These results indicate that the −831C/T polymorphism has a direct effect on transcriptional regulation of PXR gene. This allelic variation may be a potential genetic marker that can help identify individuals at higher risk for Inflammatory Bowel Disease (IBD).
Supercritical Antisolvent Precipitation of Amorphous Copper–Zinc Georgeite and Acetate Precursors for the Preparation of Ambient‐Pressure Water‐Gas‐Shift Copper/Zinc Oxide Catalysts
Authors: Smith Paul J. , Kondrat Simon A. , Carter James H. , Chater Philip A. , Bartley Jonathan K. , Taylor Stuart H. , Spencer Michael S. , Hutchings Graham J. 
Published: February 2017

AbstractA series of copper–zinc acetate and zincian georgeite precursors have been produced by supercritical CO2 antisolvent (SAS) precipitation as precursors to Cu/ZnO catalysts for the water gas shift (WGS) reaction. The amorphous materials were prepared by varying the water/ethanol volumetric ratio in the initial metal acetate solutions. Water addition promoted georgeite formation at the expense of mixed metal acetates, which are formed in the absence of the water co‐solvent. Optimum SAS precipitation occurs without water to give high surface areas, whereas high water content gives inferior surface areas and copper–zinc segregation. Calcination of the acetates is exothermic, producing a mixture of metal oxides with high crystallinity. However, thermal decomposition of zincian georgeite resulted in highly dispersed CuO and ZnO crystallites with poor structural order. The georgeite‐derived catalysts give superior WGS performance to the acetate‐derived catalysts, which is attributed to enhanced copper–zinc interactions that originate from the precursor.
Sn‐MoS2‐C@C Microspheres as a Sodium‐Ion Battery Anode Material with High Capacity and Long Cycle Life
Authors: Zheng Fenghua , Pan Qichang , Yang Chenghao , Xiong Xunhui , Ou Xing , Hu Renzong , Chen Yu , Liu Meilin 
Published: February 2017

AbstractSodium ion batteries (SIBs) have been regarded as a prime candidate for large‐scale energy storage, and developing high performance anode materials is one of the main challenges for advanced SIBs. Novel structured Sn‐MoS2‐C@C microspheres, in which Sn nanoparticles are evenly embedded in MoS2 nanosheets and a thin carbon film is homogenously engineered over the microspheres, have been fabricated by the hydrothermal method. The Sn‐MoS2‐C@C microspheres demonstrate an excellent Na‐storage performance as an anode of SIBs and deliver a high reversible charge capacity (580.3 mAh g−1 at 0.05 Ag−1) and rate capacity (580.3, 373, 326, 285.2, and 181.9 mAh g−1at 0.05, 0.5, 1, 2, and 5 Ag−1, respectively). A high charge specific capacity of 245 mAh g−1 can still be achieved after 2750 cycles at 2 Ag−1, indicating an outstanding cycling performance. The high capacity and long‐term stability make Sn‐MoS2‐C@C composite a very promising anode material for SIBs.
Vitamin B12 Catalysis: Probing the Structure/Efficacy Relationship
Authors: Karczewski Maksymilian , Ociepa Michał , Pluta Katarzyna , ó Proinsias Keith , Gryko Dorota 
Published: February 2017

AbstractVitamin B12 is a cofactor for many enzymes, but it also functions as a catalyst in C−C bond‐forming reactions. Herein, the impact of corrin structural modifications on their catalytic efficacy was examined. Derivatives with various substituents at c‐, d‐, and meso‐positions were synthesised by using traditional and new microwave methodologies, and then tested in the model reaction of 1,1‐diphenylethylene with ethyl diazoacetate. To complement the experimental data, cyclic voltammetry and DFT calculations were performed. Mainly alterations at the c‐ or d‐positions influence both the reaction yield and selectivity.
Highly selective Fischer‐Tropsch synthesis for C10‐C20 diesel fuel under low pressure
Authors: Dong Zhen , Zhang Haiping , Whidden Tom , Zheng Ying , Zhao Jianshe 
Published: February 2017

AbstractThis work deals with the improvement of diesel (C10‐C20) production of Fischer‐Tropsch (FT) synthesis at low pressure over Co‐Re/Al2O3 since high catalytic activity and great potential in producing C10‐C20 hydrocarbons were observed under conventional conditions. To improve the catalytic performance, CO conversion and hydrocarbon selectivity were investigated against pressure, syngas H2/CO ratio, gas flow rate, and temperature. 93.7 % of CO conversion was achieved as well as 62.3 % diesel selectivity over Co‐Re/Al2O3 catalyst even after working for 15 days, which was far higher than the maximum value of the Anderson‐Schulz‐Flory (ASF) distribution and the results in literature reports. It is suggested that Re plays an important role in enhancing dissociation of hydrogen as well as the formation of CH, CH2, and CH3 species to convert CO.
Symptom incidence, distress, cancer‐related distress, and adherence to chemotherapy among African American women with breast cancer
Authors: Yee Melissa K. , Sereika Susan M. , Bender Catherine M. , Brufsky Adam M. , Connolly Mary C. , Rosenzweig Margaret Q. 
Published: February 2017

BACKGROUNDThere is a persistent racial survival disparity between African American (AA) and white women with breast cancer. There is evidence that symptom incidence, associated distress, and overall cancer‐related distress may be unexplored, important contributing factors. The purpose of the current study was to: 1) describe and compare the number of chemotherapy‐related symptoms and associated distress among AA women with breast cancer over the course of chemotherapy at 3 time points (at baseline before initiating chemotherapy, midpoint, and at the completion of chemotherapy); and 2) to describe the relationship between the number of chemotherapy‐related symptoms and overall cancer distress compared with the ability to receive at least 85% of the prescribed chemotherapy within the prescribed timeframe.METHODSDescriptive, comparative, and correlational analyses of symptom incidence, symptom distress, cancer‐related distress, and prescribed chemotherapy dose received among a cohort of AA women receiving chemotherapy for breast cancer were performed.RESULTSAA women (121 women) experienced worsening symptoms from baseline to midpoint in chemotherapy and then stabilized for the duration of therapy. The inability to receive 85% of the prescribed chemotherapy within a prescribed time point was found to be significantly correlated with midpoint symptom distress.CONCLUSIONSThe main findings of the current study were that AA women experience a deterioration in symptom distress over the course of chemotherapy from baseline (before chemotherapy) to the midpoint, which was found to be associated with less adherence to chemotherapy overall. Thus, the incidence and management of physical and emotional symptoms, as measured through a multidimensional symptom measurement tool, may be contributing to breast cancer dose disparity and should be explored further. Cancer 2017;123:2061–2069. © 2017 American Cancer Society.
Charge Neutralization Strategy: A Novel Synthetic Approach to Fully Cationized Thiolate‐Protected Au25(SR+)18 Clusters with Atomic Precision
Authors: Ishida Yohei , Huang Yu‐Ling , Yonezawa Tetsu , Narita Kunihiro 
Published: February 2017

AbstractMany thiolate‐protected molecular Au clusters, of different cluster sizes and with varying neutral or anionic thiolate ligands, have been reported over the past two decades. Despite this abundance of information, to date there has been no report of atomically pure cationized molecular Au clusters that are protected with cationic thiolates. We herein present a novel, facile and high‐yield synthetic approach towards producing a new series of thiolate‐protected molecular Au clusters: a fully cationized Au25(SR+)18 cluster with atomic precision. The simple “charge neutralization strategy” presented enables treatment of the cationic thiols as neutral thiols, thus the well‐established method for preparing Au25 clusters with neutral thiolates can be adopted for cationic Au25 clusters at a very high synthetic yield. We believe that this report will widen the spectrum of gold cluster chemistry and also help in the further development of cationized molecular clusters with various metals, core sizes, and ligand structures.
Sustainable Development in Spanish Listed Companies: A Strategic Approach
Authors: Charlo Maria J. , Moya Ismael , Muñoz Ana M. 
Published: February 2017

AbstractCompanies should be interested in implementing corporate social responsibility (CSR) practices not only for ethical reasons, but also for their potential profits. Considering the need to confirm this relationship more thoroughly, this research is based on the only stock market index in Spain which is an objective indicator of best business practices. The purpose of this study is to find out whether being listed in the FTSE4Good IBEX explains a different ulterior financial performance. To this end, the potential accounting and stock market differences between two groups of companies listed in the Spanish IBEX are analysed: those classified as responsible due to their inclusion in the responsible company index and those companies which, as they are not in it, do not receive this denomination. The study, conducted according to the CSR strategic approach, covers 2008–2013. Its outcomes confirm the presence of significant differences between the two groups. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
MechanoAPI‐ILs: Pharmaceutical Ionic Liquids Obtained through Mechanochemical Synthesis
Authors: Martins Inês C. B. , Oliveira M. Conceição , Diogo Hermínio P. , Branco Luís C. , Duarte M. Teresa 
Published: February 2017

AbstractAn alternative, efficient, and green synthetic strategy for the preparation of pharmaceutical ionic liquids using mechanochemistry (MechanoAPI‐ILs) is reported. Six new API‐ILs based on gabapentin and l‐glutamic acid were successfully synthesized and characterized, demonstrating that mechanochemistry is a very promising synthetic strategy. Results compare both the new and the classical approach and clearly show the advantages of the new method. This new technique is faster, solvent free, reproducible, selective, and leads to higher yields.
A comparison of the frequency of familial suicide attempts across eating disorder diagnoses
Authors: Pisetsky Emily M. , Peterson Carol B. , Mitchell James E. , Wonderlich Stephen A. , Crosby Ross D. , Le Grange Daniel , Hill Laura , Powers Pauline , Crow Scott J. 
Published: February 2017

AbstractThis study examined the prevalence of reported suicide attempts among family members of individuals with an eating disorder (ED). 1870 individuals presenting for ED treatment reported whether their family members ever made a suicide attempt using the Eating Disorders Questionnaire. A lifetime suicide attempt by any family member was reported by 10.8% (n = 202) of the sample and ranged from 7.0% of those with eating disorder not otherwise specified to 16.1% of those with purging disorder. Controlling for age and gender, individuals with bulimia nervosa had a higher prevalence of any familial suicide attempt and mother suicide attempt than individuals with EDNOS; no other differences were observed across ED diagnoses. There were no differences in prevalence of reported suicide attempts made by fathers, brothers, sisters, uncles, or aunts by ED diagnosis. Findings support a growing literature indicating a familial association between EDs and suicide risk.
A simple, fast, and repeatable survey method for underwater visual 3D benthic mapping and monitoring
Authors: Pizarro Oscar , Friedman Ariell , Bryson Mitch , Williams Stefan B. , Madin Joshua 
Published: February 2017

AbstractVisual 3D reconstruction techniques provide rich ecological and habitat structural information from underwater imagery. However, an unaided swimmer or diver struggles to navigate precisely over larger extents with consistent image overlap needed for visual reconstruction. While underwater robots have demonstrated systematic coverage of areas much larger than the footprint of a single image, access to suitable robotic systems is limited and requires specialized operators. Furthermore, robots are poor at navigating hydrodynamic habitats such as shallow coral reefs. We present a simple approach that constrains the motion of a swimmer using a line unwinding from a fixed central drum. The resulting motion is the involute of a circle, a spiral‐like path with constant spacing between revolutions. We test this survey method at a broad range of habitats and hydrodynamic conditions encircling Lizard Island in the Great Barrier Reef, Australia. The approach generates fast, structured, repeatable, and large‐extent surveys (~110 m2 in 15 min) that can be performed with two people and are superior to the commonly used “mow the lawn” method. The amount of image overlap is a design parameter, allowing for surveys that can then be reliably used in an automated processing pipeline to generate 3D reconstructions, orthographically projected mosaics, and structural complexity indices. The individual images or full mosaics can also be labeled for benthic diversity and cover estimates. The survey method we present can serve as a standard approach to repeatedly collecting underwater imagery for high‐resolution 2D mosaics and 3D reconstructions covering spatial extents much larger than a single image footprint without requiring sophisticated robotic systems or lengthy deployment of visual guides. As such, it opens up cost‐effective novel observations to inform studies relating habitat structure to ecological processes and biodiversity at scales and spatial resolutions not readily available previously.
Combined environmental risk assessment for the antiviral pharmaceuticals ganciclovir and valganciclovir in Europe
Authors: Straub Jürg Oliver 
Published: February 2017

Abstract

Potential environmental risks of the old antiviral pharmaceuticals ganciclovir (GCV) and valganciclovir (VGCV) were reassessed based on new environmental fate and chronic ecotoxicity tests and on actual use data for Europe. Valganciclovir is hydrolyzed to GCV by intestinal and hepatic esterases, and hence the new environmental tests only refer to GCV. A sorption study showed that GCV will not sorb significantly, excluding the soil as a relevant environmental compartment. Despite earlier data suggesting nondegradability, a new water/sediment fate test showed GCV to be primarily and ultimately degraded and to be nonpersistent. The chronic ecotoxicity tests with algae and daphnids resulted in no inhibition at the highest tested concentrations, whereas a fish partial life cycle test, selected in view of mammalian mutagenicity and reprotoxicity data, showed effects on growth of the young fish, but not on gametogenesis, fertilization, embryogenesis, or teratogenicity. Predicted environmental concentrations were derived based on actual per capita use data for European countries for 2004 to 2014, and the highest was selected for the risk assessment. A comparison of predicted environmental concentrations with predicted no-effect concentrations shows no significant risk for wastewater treatment, surface waters, groundwater, or sediment. In addition, potential risks to (semi)aquatic top predators or to human consumers of water and fish are exceedingly low. Environ Toxicol Chem 2017;36:2205–2216. © 2017 The Author. Environmental Toxicology and Chemistry Published by Wiley Periodicals, Inc. on behalf of SETAC
Birth injuries to growth plates: A sheep in wolves' clothing
Authors: Varghese Jerrin , Teng Matthew , Huang Mingqian , Balsam Dvorah 
Published: February 2017

ABSTRACTGrowth plate injuries (Salter‐Harris type 1 or physeal fractures) of the long bones in the newborn are easily misdiagnosed as joint fractures with dislocations due to their nonossified epiphyses on plain radiographs. Diagnosis with musculoskeletal ultrasound (US) is advantageous due to its ability to visualize the nonossified epiphysis. We present two cases of humeral growth plate fractures in newborns, one at the shoulder (proximal humerus) and the other at the elbow (distal humerus). These cases emphasize the importance of quick and noninvasive diagnosis with US to avoid unnecessary intervention. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 45:511–514, 2017
Oxidative stress gene polymorphisms may have an impact in the development of ischemic stroke
Authors: Karahalil Bensu , Elkama Aylin , Orhan Gürdal 
Published: February 2017

AbstractBackgroundAntioxidants are responsible for detoxification of harmful effects of reactive oxygen species. Genetic factors may influence antioxidant activity as a result of polymorphisms on antioxidant enzymes. These polymorphisms can be risk in ischemic stroke (IS) risk. IS is a disorder with genetic and environmental factors contributing to overall risk. Although a few studies have been conducted, there have been no reports on catalase (CAT C262T), manganese superoxide dismutase (MnSOD Ala16Val) and glutathione peroxidase 1 (GPX1 Pro198Leu) gene polymorphisms and IS risk.MethodsWe aimed to perform a case–control study to increase the awareness of the impact of oxidative stress (OS) gene polymorphism in the development of IS. A restriction fragment length polymorphism‐polymerase chain reaction was used to determine genotypes. The interactions between genes and smoking and possible risk factors were evaluated.ResultsAn approximately four‐fold higher IS risk was found in patients with the Val allele compared to the Ala allele. Smoking was a risk factor in the development of IS for CAT TT and MnSOD Ala/Val genotypes; we found a 3.5‐ to 5.5‐fold higher IS risk in CAT TT and MnSOD Ala/Val genotypes. Different logistic regression models were performed for possible risk factors (smoking, body mass index, low‐density lipoprotein and diabetes mellitus). The IS risk increases statistically significant only with age by multiple logistic regression analysis. CAT gene polymorphisms in IS patients were not different from controls.ConclusionsIt is unlikely that CAT and GPX1 single nucleotide polymorphisms are risk factors for IS. The results of the present study show that smoking may be a risk factor for IS risk in patients with MnSOD mutant genotypes.
Radiomics assessment of bladder cancer grade using texture features from diffusion‐weighted imaging
Authors: Zhang Xi , Xu Xiaopan , Tian Qiang , Li Baojuan , Wu Yuxia , Yang Zengyue , Liang Zhengrong , Liu Yang , Cui Guangbin , Lu Hongbing 
Published: February 2017

PurposeTo 1) describe textural features from diffusion‐weighted images (DWI) and apparent diffusion coefficient (ADC) maps that can distinguish low‐grade bladder cancer from high‐grade, and 2) propose a radiomics‐based strategy for cancer grading using texture features.Materials and MethodsIn all, 61 patients with bladder cancer (29 in high‐ and 32 in low‐grade groups) were enrolled in this retrospective study. Histogram‐ and gray‐level co‐occurrence matrix (GLCM)‐based radiomics features were extracted from cancerous volumes of interest (VOIs) on DWI and corresponding ADC maps of each patient acquired from 3.0T magnetic resonance imaging (MRI). A Mann–Whitney U‐test was applied to select features with significant differences between low‐ and high‐grade groups (P < 0.05). Then support vector machine with recursive feature elimination (SVM‐RFE) and classification strategy was adopted to find an optimal feature subset and then to establish a classification model for grading.ResultsA total 102 features were derived from each VOI and among them, 47 candidate features were selected, which showed significant intergroup differences (P < 0.05). By the SVM‐RFE method, an optimal feature subset including 22 features was further selected from candidate features. The SVM classifier using the optimal feature subset achieved the best performance in bladder cancer grading, with an area under the receiver operating characteristic curve, accuracy, sensitivity, and specificity of 0.861, 82.9%, 78.4%, and 87.1%, respectively.ConclusionTextural features from DWI and ADC maps can reflect the difference between low‐ and high‐grade bladder cancer, especially those GLCM features from ADC maps. The proposed radiomics strategy using these features, combined with the SVM classifier, may better facilitate image‐based bladder cancer grading preoperatively.Level of Evidence: 3Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2017;46:1281–1288.
A Newly Designed Dual‐Functional Epoxy Monomer for Preparation of Fishbone‐Shaped Heterochain Polymer with a High Damping Property at Low Temperature
Authors: Li Yan , Cheng Jue , Zhang Junying 
Published: February 2017

A novel high purity dual‐functional epoxy monomer, diglycidyl ether of 4,4′‐diallyl‐bisphenol‐A, is deliberately designed for the construction of a fishbone‐shaped heterochain polymer by polymerizing it with the methyl phenyl polysiloxane. Their curing reactions with Jeffamine D230 are investigated. The cured fishbone‐shaped heterochain polymer presents a wide transition range spanning over 120 °C with a peak half‐width of 62 °C. In contrast to the traditional epoxy/polysiloxane materials, the cured fishbone‐shaped heterochain polymer takes full advantage of the cooperative effect of epoxy and polysiloxane exhibiting excellent damping properties (tan δ > 0.3) at temperatures near the T
g of the polysiloxane. This outstanding low‐temperature damping performance can be ascribed to the fishbone‐shaped structure of the heterochain polymer. These results provide new approach to explore high damping materials used at extremely low temperature (−125 °C).
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