bluuebunny/crossref_metadata_2025_split huggingface dataset:
Di(hydroperoxy)alkane Adducts of Phosphine Oxides: Safe, Solid, Stoichiometric, and Soluble Oxidizing Agents
Authors: Ahn Shin Hye , Bhuvanesh Nattamai , Blümel Janet 
Published: August 2017

AbstractThe di(hydroperoxy)alkane adducts of phosphine oxides 1–9, Ph3PO⋅(HOO)2CMe2, Cy3PO⋅(HOO)2CMe2, Ph3PO⋅ (HOO)2CMeEt, Cy3PO⋅(HOO)2CMeEt, Cy3PO⋅(HOO)2CEt2, Cy3PO⋅ (HOO)2C(CH2)5, Cy3PO⋅(HOO)2CMePh, (Ph2P(O)CH2CH2P(O)Ph2)⋅ ((HOO)2CEt2)2, and Ph2P(O)CH2P(O)Ph2⋅(HOO)2CMe2, respectively, are synthesized and fully characterized by 1H, 13C, and 31P NMR, and IR spectroscopies. Single crystal X‐ray structures are reported for 3–9. Different one‐pot synthetic pathways, starting from R3P, R3PO, R3PO⋅H2O, and R3PO⋅H2O2 are explored and discussed and a mechanism for the formation of the di(hydroperoxy)alkane adducts of phosphine oxides is suggested. The longevity of the adducts is tested by monitoring the oxidation of Ph3P with quantitative NMR. The solubilities of the adducts in organic solvents are presented, and their applicability as stoichiometric oxidizing agents for the selective oxidation of sulfides to sulfoxides is reported.
Animating static objects by illusion‐based projection mapping
Authors: Fukiage Taiki , Kawabe Takahiro , Sawayama Masataka , Nishida Shin'ya 
Published: August 2017

AbstractBy applying scientific knowledge about human visual processing, we have recently developed a light projection technique, called Deformation Lamps, which can add a variety of illusory, yet realistic distortions, to a wide range of static projection targets. In this paper, to explain how Deformation Lamps works, we first describe its basic algorithm and related human visual processing. We then describe the latest version of the Deformation Lamps system. It is a ready‐to‐use application that automatically finds projection targets and projects motion‐inducer patterns in alignment with images or textures on the targets' surfaces. The application also supports interactive editing of animation contents.
Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry
Authors: Tward Daniel J. , Sicat Chelsea S. , Brown Timothy , Bakker Arnold , Gallagher Michela , Albert Marilyn , Miller Michael ,   Alzheimer's Disease Neuroimaging Initiative
Published: August 2017

AbstractIntroductionAutopsy findings have shown the entorhinal cortex and transentorhinal cortex are among the earliest sites of accumulation of pathology in patients developing Alzheimer's disease.MethodsHere, we study this region in subjects with mild cognitive impairment (n = 36) and in control subjects (n = 16). The cortical areas are manually segmented, and local volume and shape changes are quantified using diffeomorphometry, including a novel mapping procedure that reduces variability in anatomic definitions over time.ResultsWe find significant thickness and volume changes localized to the transentorhinal cortex through high field strength atlasing.DiscussionThis demonstrates that in vivo neuroimaging biomarkers can detect these early changes among subjects with mild cognitive impairment.
“Stiction Syndrome”: Non-Operative Management of Patients with Difficult AMS 700 Series Inflation
Authors: Kavoussi Nicholas L. , Viers Boyd R. , VanDyke Maia E. , Pagliara Travis J. , Morey Allen F. 
Published: August 2017

Abstract

Introduction
Static friction (stiction) is a mechanical phenomenon in which a state of increased resistance exists across a control valve mechanism.

Aim
To present a strategy for non-operative management of inflatable penile prosthesis (IPP) cases with pump malfunction from pump valve stiction.

Methods
All patients had American Medical Systems (AMS; Minnetonka, MN, USA) 700 series Momentary Squeeze IPPs with transient pump malfunction owing to pump valve stiction after extended periods of device inactivity.

Main Outcome Measures
Our evolving non-operative management experience with the “forced deflation” maneuver is described. This technique has successfully prevented the need for surgical pump replacement. Of patients with IPP who were instructed to inflate and deflate daily to prevent stiction recurrence, none have re-presented with difficult inflation.

Results
Of 306 patients receiving the AMS 700 series IPP at our institution from 2007 through 2015, 6 (1.9%) presented with difficulty activating the Momentary Squeeze pump (from 2011 through 2015). Four additional patients were referred from outside institutions with the same complaint. All patients (10 of 10, 100%) presented after a prolonged period of inactivity (minimum = 6 weeks) during which the IPP was not cycled and remained stagnant. Although the initial four patients (40%) underwent surgical exploration with pump mobilization and replacement, the six most recent patients (60%) were successfully instructed in the forced deflation maneuver in the office, which enabled the device to cycle normally thereafter.

Conclusion
Device inactivity, for as little as 6 weeks, can predispose to Momentary Squeeze pump valve malfunction; and a regimen of daily IPP cycling could prevent stiction-related malfunction. Our findings should encourage practitioners to attempt conservative management of patients with “stiction syndrome” whenever possible, thereby avoiding unnecessary surgery.
Different Characteristics of the Female Sexual Function Index in a Sample of Sexually Active and Inactive Women
Authors: Hevesi Krisztina , Mészáros Veronika , Kövi Zsuzsanna , Márki Gabriella , Szabó Marianna 
Published: August 2017

Abstract

Background
The Female Sexual Function Index (FSFI) is a widely used measurement tool to assess female sexual function along the six dimensions of desire, arousal, lubrication, orgasm, satisfaction, and pain. However, the structure of the questionnaire is not clear, and several studies have found high correlations among the dimensions, indicating that a common underlying “sexual function” factor might be present.

Aim
To investigate whether female sexual function is best understood as a multidimensional construct or, alternatively, whether a common underlying factor explains most of the variance in FSFI scores, and to investigate the possible effect of the common practice of including sexually inactive women in studies using the FSFI.

Methods
The sample consisted of 508 women: 202 university students, 177 patients with endometriosis, and 129 patients with polycystic ovary syndrome. Participants completed the FSFI, and confirmatory factor analyses were used to test the underlying structure of this instrument in the total sample and in samples including sexually active women only.

Outcomes
The FSFI is a multidimensional self-report questionnaire composed of 19 items.

Results
Strong positive correlations were found among five of the six original factors on the FSFI. Confirmatory factor analyses showed that in the total sample items loaded mainly on the general sexual function factor and very little variance was explained by the specific factors. However, when only sexually active women were included in the analyses, a clear factor structure emerged, with items loading on their six specific factors, and most of the variance in FSFI scores was explained by the specific factors, rather than the general factor. University students reported higher scores, indicating better functioning compared with the patient samples.

Clinical Translation
The reliable and valid assessment of female sexual function can contribute to better understanding, prevention, and treatment of different sexual difficulties and dysfunctions.

Strengths and Limitations
This study provides a rigorous statistical test of the structure of the FSFI and an explicit decision rule for categorizing sexually inactive women. Limitations include a lack of control over the circumstances of data collection.

Conclusion
This study supports the use of the FSFI as a multidimensional measurement of female sexual function but highlights the need to establish clear decision rules for the inclusion or exclusion of sexually active and inactive respondents.
‘Shiny shoes’ for the city: the public abattoir and the reform of meat supply in imperial Moscow
Authors: MAZANIK ANNA 
Published: August 2017

ABSTRACT:In the nineteenth century, meat production underwent radical changes, turning into a mass-scale and industrial process that was based on the new norms of hygiene and veterinary medicine. Anthropologists and cultural historians have pointed out that, in a western European context, this also entailed the marginalization of the slaughterhouses, which were excluded from urban life and made anonymous and invisible. This article examines the case of the Moscow public abattoir (1886–88) and argues that, instead of being marginalized, it emerged as one of the city's landmarks due to its important symbolic role in the Russian discussions on modernization and ‘Europeanness’.
Strategies for public health initiatives targeting dairy consumption in young children: a qualitative formative investigation of parent perceptions
Authors: Jung Mary E , Bourne Jessica E , Buchholz Andrea , Martin Ginis Kathleen A 
Published: August 2017

AbstractObjectiveDairy products contain essential nutrients to ensure healthy growth and bone development in children. However, a significant proportion of children in developed countries fail to consume the daily recommended intake of dairy products. Parents are the gatekeepers of familial nutritional intake and represent a potential vehicle through which to increase dairy consumption in children. As such, formative research was conducted to gain insight into parents’ perceived barriers to and benefits of purchasing and consuming dairy products and to develop innovative message content that could be utilized in future public health campaigns.DesignSeven in-depth group interviews were conducted in two phases between February and May 2015.SettingInterviews were conducted in local recreational centres and libraries in British Columbia, Canada.SubjectsMothers (n21, mean age 38 (sd5) years) and fathers (n9, mean age 38 (sd3) years) of children aged 4–10 years.ResultsParents perceived both positive and negative physical outcomes associated with consuming dairy. Lack of trustworthy information was a frequently discussed barrier theme to purchasing and consuming dairy products. Mothers were concerned about the cost of dairy products. Differences in purchasing and consumption strategies were reported between parents of children who consumed adequate dairy and those who did not. Parents believed the most appropriate communication channel was through print material.ConclusionsMessages targeting parents, as a means of increasing dairy consumption in children, should address barriers identified by parents. In addition, practical tips should be provided to promote purchasing and consumption of dairy products.
When you must forget: Beyond strong persistence when forgetting in answer set programming
Authors: GONÇALVES RICARDO , KNORR MATTHIAS , LEITE JOÃO , WOLTRAN STEFAN 
Published: August 2017

AbstractAmong the myriad of desirable properties discussed in the context of forgetting in Answer Set Programming,strong persistencenaturally captures its essence. Recently, it has been shown that it is not always possible to forget a set of atoms from a program while obeying this property, and a precise criterion regarding what can be forgotten has been presented, accompanied by a class of forgetting operators that return the correct result when forgetting is possible. However, it is an open question what to do when we have to forget a set of atoms, but cannot without violating this property. In this paper, we address this issue and investigate three natural alternatives to forget when forgetting without violating strong persistence is not possible, which turn out to correspond to the different possible relaxations of the characterization of strong persistence. Additionally, we discuss their preferable usage, shed light on the relation between forgetting and notions of relativized equivalence established earlier in the context of Answer Set Programming, and present a detailed study on their computational complexity.
Sargassum muticum and Jania rubens regulate amino acid metabolism to improve growth and alleviate salinity in chickpea
Authors: Abdel Latef Arafat Abdel Hamed , Srivastava Ashish Kumar , Saber Hani , Alwaleed Eman A. , Tran Lam-Son Phan 
Published: August 2017

AbstractThe present study evaluates the potential of Sargassum muticum (Sar) and Jania rubens (Jan) seaweeds for enhancing growth and mitigating soil-salinity in chickpea (Cicer arietinum L.). Under control conditions, Sar and Jan extracts improved chickpea growth which was attributed to their potential for increasing photosynthetic pigments, K+ and amino acids, particularly proline, in comparison with water-sprayed control. Upon stress imposition, chickpea growth was reduced in NaCl concentration-dependent manner, and principal component analysis (PCA) revealed Na+ accumulation and oxidative damage as major determinants of sensitivity at high salinity. Furthermore, amino acid quantification indicated activation/deactivation of overall metabolism in roots/shoots, as an adaptive strategy, for maintaining plant growth under salt stress. Sar and Jan extract supplementations provided stress amelioration, and PCA confirmed that improved growth parameters at high salinity were associated with enhanced activities of superoxide dismutase and peroxidase. Besides, four key amino acids, including serine, threonine, proline and aspartic acids, were identified from roots which maximally contribute to Sar- and Jan-mediated stress amelioration. Sar showed higher effectiveness than Jan under both control and salt stress conditions. Our findings highlight “bio-stimulant” properties of two seaweeds and provide mechanistic insight into their salt-ameliorating action which is relevant for both basic and applied research.
Amixicile, a novel strategy for targeting oral anaerobic pathogens
Authors: Hutcherson Justin A. , Sinclair Kathryn M. , Belvin Benjamin R. , Gui Qin , Hoffman Paul S. , Lewis Janina P. 
Published: August 2017

AbstractThe oral microflora is composed of both health-promoting as well as disease-initiating bacteria. Many of the disease-initiating bacteria are anaerobic and include organisms such asPorphyromonas gingivalis,Prevotella intermedia,Fusobacterium nucleatum, andTannerella forsythia. Here we investigated a novel therapeutic, amixicile, that targets pyruvate:ferredoxin oxidoreductase (PFOR), a major metabolic enzyme involved in energy generation through oxidative decarboxylation of pyruvate. PFOR is present in these anaerobic pathogenic bacteria and thus we hypothesized that amixicile would effectively inhibit their growth. In general, PFOR is present in all obligate anaerobic bacteria, while oral commensal aerobes, including aerotolerant ones, such asStreptococcus gordonii, use pyruvate dehydrogenase to decarboxylate pyruvate. Accordingly, we observed that growth of the PFOR-containing anaerobic periodontal pathogens, grown in both monospecies as well as multispecies broth cultures was inhibited in a dose-dependent manner while that ofS.gordoniiwas unaffected. Furthermore, we also show that amixicile is effective against these pathogens grown as monospecies and multispecies biofilms. Finally, amixicile is the first selective therapeutic agent active against bacteria internalized by host cells. Together, the results show that amixicile is an effective inhibitor of oral anaerobic bacteria and as such, is a good candidate for treatment of periodontal diseases.
Maternal Habitual Midday Napping Duration and Frequency are Associated with High Birthweight
Authors: Zheng Xiaoxuan , Zhang Lina , Shen Lijun , Song Lulu , Li Hui , Liu Bingqing , Li Yuanyuan , Xia Wei , Zhang Bin , Xu Shunqing , Wang Youjie 
Published: August 2017

AbstractHabitual midday napping is a common habit in China, especially for pregnant women. The purpose of this study was to examine whether duration and frequency of maternal habitual midday napping were associated with high birthweight (HBW). A total of 10,482 participants from Healthy Baby Cohort were include in our analysis. The information of the mothers and their infants were abstracted from medical records, or obtained from questionnaire. Logistic regression models were used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of habitual midday napping duration and frequency with HBW. Of the participants, 8,705 (83.0%) reported having habitual midday napping. Duration and frequency of napping had a positive association with HBW without adjustment. After controlling for potential confounders, increasing risk of HBW was observed in participants who napped 1.5–2 hours (OR, 1.50, 95% CI, 1.14, 1.98), and ≥2 hours (OR, 1.35, 95% CI, 1.03, 1.78) compared with no habitual midday napping. Participants who took naps ≥5 days/week had a higher risk of HBW (OR, 1.37, 95% CI, 1.07, 1.77) compared with the women without naps. This suggests that longer (≥1.5 hours) and more frequent (≥5 days/week) maternal habitual midday napping were associated with an increased risk of HBW.
Inter-Patient ECG Heartbeat Classification with Temporal VCG Optimized by PSO
Authors: Garcia Gabriel , Moreira Gladston , Menotti David , Luz Eduardo 
Published: August 2017

AbstractClassifying arrhythmias can be a tough task for a human being and automating this task is highly desirable. Nevertheless fully automatic arrhythmia classification through Electrocardiogram (ECG) signals is a challenging task when the inter-patient paradigm is considered. For the inter-patient paradigm, classifiers are evaluated on signals of unknown subjects, resembling the real world scenario. In this work, we explore a novel ECG representation based on vectorcardiogram (VCG), called temporal vectorcardiogram (TVCG), along with a complex network for feature extraction. We also fine-tune the SVM classifier and perform feature selection with a particle swarm optimization (PSO) algorithm. Results for the inter-patient paradigm show that the proposed method achieves the results comparable to state-of-the-art in MIT-BIH database (53% of Positive predictive (+P) for the Supraventricular ectopic beat (S) class and 87.3% of Sensitivity (Se) for the Ventricular ectopic beat (V) class) that TVCG is a richer representation of the heartbeat and that it could be useful for problems involving the cardiac signal and pattern recognition.
Unravelling a stearidonic acid-rich triacylglycerol biosynthetic pathway in the developing seeds of Buglossoides arvensis: A transcriptomic landscape
Authors: Sreedhar R. V. , Prasad P. , Reddy L. Prasanna Anjaneya , Rajasekharan Ram , Srinivasan Malathi 
Published: August 2017

AbstractBuglossoides arvensis is an emerging oilseed crop that is rich in stearidonic acid (SDA) and has several potential applications in human health and nutrition. The molecular basis of SDA biosynthesis in this plant remains unknown due to lack of genomic information. To unravel key genes involved in SDA-rich triacylglycerol (TAG) biosynthesis, we performed transcriptome sequencing of pooled mRNA from five different developmental stages of B. arvensis seeds using Illumina NextSeq platform. De novo transcriptome assembly generated 102,888 clustered transcripts from 39.83 million high-quality reads. Of these, 62.1% and 55.54% of transcripts were functionally annotated using Uniprot-Viridiplantae and KOG databases, respectively. A total of 10,021 SSR-containing sequences were identified using the MISA tool. Deep mining of transcriptome assembly using in silico tools led to the identification of genes involved in fatty acid and TAG biosynthesis. Expression profiling of 17 key transcripts involved in fatty acid desaturation and TAG biosynthesis showed expression patterns specific to the development stage that positively correlated with polyunsaturated fatty acid accumulation in the developing seeds. This first comprehensive transcriptome analysis provides the basis for future research on understanding molecular mechanisms of SDA-rich TAG accumulation in B. arvensis and aids in biotechnological production of SDA in other oilseed crops.
Prediction of miRNA-disease Associations using an Evolutionary Tuned Latent Semantic Analysis
Authors: Pallez Denis , Gardès Julien , Pasquier Claude 
Published: August 2017

AbstractMicroRNAs, small non-coding elements implied in gene regulation, are very interesting biomarkers for various diseases such as cancers. They represent potential prodigious biotechnologies for early diagnosis and gene therapies. However, experimental verification of microRNA-disease associations are time-consuming and costly, so that computational modeling is a proper solution. Previously, we designed MiRAI, a predictive method based on distributional semantics, to identify new associations between microRNA molecules and human diseases. Our preliminary results showed very good prediction scores compared to other available methods. However, MiRAI performances depend on numerous parameters that cannot be tuned manually. In this study, a parallel evolutionary algorithm is proposed for finding an optimal configuration of our predictive method. The automatically parametrized version of MiRAI achieved excellent performance. It highlighted new miRNA-disease associations, especially the potential implication of mir-188 and mir-795 in various diseases. In addition, our method allowed to detect several putative false associations contained in the reference database.
A single neonatal administration of Bisphenol A induces higher tumour weight associated to changes in tumour microenvironment in the adulthood
Authors: Palacios-Arreola Margarita Isabel , Nava-Castro Karen Elizabeth , Río-Araiza Víctor Hugo Del , Pérez-Sánchez Nashla Yazmín , Morales-Montor Jorge 
Published: August 2017

AbstractBPA is an oestrogenic endocrine disrupting chemical compound. Exposure to BPA in as early as pregnancy leads to lifelong effects. Since endocrine and immune systems interact in a bidirectional manner, endocrine disruption may cause permanent alterations of the immune system, affecting a future anti-tumoral response. Neonate (PND 3) female syngeneic BALB/c mice were exposed to a single dose of 250 µg/kg BPA. Once sexual maturity was reached, a mammary tumour was induced injecting 4T1 cells in situ, these cells are derived from a spontaneous adenocarcinoma in a BALB/c mouse and therefore allows for an immunocompetent recipient. After 25 days of injection, showing no major endocrine alterations, BPA-exposed mice developed larger tumours. Tumour leukocytic infiltrate analysis revealed a higher proportion of regulatory T lymphocytes in the BPA-exposed group. RT-PCR analysis of tumour samples showed a decreased expression of TNF-α and IFN-γ, as well as the M2 macrophage marker Fizz-1 in the BPA-exposed group. Flow cytometry analysis revealed differences in ERα expression by T lymphocytes, macrophages and NK cells, both associated to BPA exposure and tumour development. These findings show a new aspect whereby early life BPA exposure can contribute to breast cancer development and progression by modulating the anti-tumoral immune response.