bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between use of the 21‐gene recurrence score assay and chemotherapy regimen selection in a statewide registry
Authors: Henry N. Lynn , Braun Thomas M. , Ali Haythem Y. , Munir Khan , Silver Samuel M. , Gorski David H. , Breslin Tara M. , Griggs Jennifer J. 
Published: October 2016

BACKGROUNDThe 21‐gene recurrence score (RS) assay predicts response to adjuvant chemotherapy in patients with early‐stage, hormone receptor‐positive, human epidermal growth factor receptor 2 (HER2)‐negative invasive breast cancer, but to the authors' knowledge, the role of the assay in guiding the selection of chemotherapy regimen has not been established. The current study was conducted to examine patterns of use of the RS assay for selecting chemotherapy regimens across a statewide registry from 2006 through 2013.METHODSDemographic, pathologic, and treatment data were abstracted from medical records for 16,666 women with breast cancer who were treated at 25 hospital systems across Michigan that were participating in the Michigan Breast Oncology Quality Initiative. Treatment patterns were examined based on the RS assay test result.RESULTSApproximately 25% of patients with lymph node‐negative disease who underwent testing with the RS assay and who were treated with chemotherapy received an anthracycline‐based regimen, compared with 49% of patients with lymph node‐negative disease who were treated with chemotherapy and who had not undergone testing with the RS assay. Of those patients with lymph node‐positive disease who underwent testing with the RS assay and who received chemotherapy, 31% received an anthracycline‐based regimen. In comparison, 71% of patients with lymph node‐positive, chemotherapy‐treated disease who did not undergo testing received an anthracycline. From 2006 through 2013, there was a statistically significant decrease in the use of anthracycline‐containing regimens in both patients with lymph node‐negative and lymph node‐positive disease.CONCLUSIONSUse of anthracycline‐containing chemotherapy regimens in eligible patients appears to vary with use of the RS assay, despite the lack of evidence supporting use of the assay to guide regimen selection. Results of ongoing prospective trials should help to define the role of the RS assay in this setting. Cancer 2017;123:948–56. © 2016 American Cancer Society.
Molecular Self‐Assembly of Cyclic Dipeptide Derivatives and Their Applications
Authors: Manchineella Shivaprasad , Govindaraju T. 
Published: October 2016

AbstractCyclic dipeptides (CDPs) are heterocyclic 2,5‐diketopiperazines with exceptional structural rigidity, enzymatic stability, and biological activity, exhibiting a substantial tendency to take part in intermolecular interactions. Strong intermolecular interactions driven by unique hydrogen bonding patterns render CDPs with a high propensity to undergo molecular self‐assembly. In this Review, the aim is to provide a comprehensive summary of design strategies used to engineer the molecular self‐assembly of CDPs into functional nano‐ and micro‐architectures and molecular gels with potential applications in biomedical and materials engineering fields.
Mechanistic Studies on Ruthenium(II)‐Catalyzed Base‐Free Transfer Hydrogenation Triggered by Roll‐Over Cyclometalation
Authors: Kerner Christian , Lang Johannes , Gaffga Maximilian , Menges Fabian S. , Sun Yu , Niedner‐Schatteburg Gereon , Thiel Werner R. 
Published: October 2016

AbstractThe synthesis of 2‐substituted pyridine–pyrimidine ligands and their complexation with arene ruthenium(II) chloride moieties is reported. Depending on the electronic and steric influences of the ligand, the catalysts undergo CH activation by roll‐over cyclometalation. This process opens up the route to the catalytic transfer hydrogenation of ketones with isopropanol as the hydrogen source under base‐free and mild conditions. Barriers related to the roll‐over cyclometalation process can be determined experimentally by collision‐induced dissociation ESI mass spectrometry. They are supported by DFT calculations and allow the classification of the ligands according to their electronic and steric properties, which is also in accordance with critical bond parameters derived from X‐ray structure data. DFT calculations furthermore reveal that the formation of a ruthenium(II) hydrido species is plausible through β‐hydride elimination from isopropanol.
Time‐aware and energy‐efficient opportunistic routing with residual energy collection in wireless sensor networks
Authors: Luo Haibo , He Minghua , Ruan Zhiqiang 
Published: October 2016

SummaryIn 1‐dimensional queue wireless sensor networks, how to balance end‐to‐end latency and energy consumption is a challenging problem. However, traditional best path routing and existing opportunistic routing protocols do not address them well because relay hop counts are usually much more, and the link appears more unreliable compared with general mesh topology. In this work, we formulate these 2 problems as a multiobjective optimization problem. Specifically, we first classify network packets into types of time tolerant and time critical and introduce a residual energy collection mechanism of neighboring nodes for forwarder set selection. We then propose a time‐aware and energy‐efficient opportunistic routing protocol (TE‐OR) to optimize energy consumption and to reduce latency for time‐critical packets. We evaluate TE‐OR by different parameters and compare it with existing protocols. The performance results show that TE‐OR achieves a trade‐off between energy consumption and time delay and balances energy consumption among nodes while guaranteeing the latency of time‐critical packets is minimized.
Risk of contrast induced nephropathy in diabetic patients affected by critical limb ischemia and diabetic foot ulcers treated by percutaneous transluminal angioplasty of lower limbs
Authors: Meloni Marco , Giurato Laura , Izzo Valentina , Stefanini Matteo , Gandini Roberto , Uccioli Luigi 
Published: October 2016

AbstractBackgroundThe aim of this study is to evaluate the risk of contrast induced nephropathy (CIN) in diabetic patients with critical limb ischemia (CLI) and foot ulcers (FUs) treated by percutaneous transluminal angioplasty of lower limbs.MethodsThe study group was composed of 145 diabetic patients who underwent a limb salvage protocol because of CLI and FUs between 2012 and 2015. All patients received a prophylactic strategy against the administration of contrast medium. Serum creatinine (SCr) levels were evaluated the day of procedure and for 3 days after. CIN was considered in case of increase of 25% of SCr in comparison to baseline value or an absolute increase of at least 0.5 mg/dl without other interfering factors.ResultsCIN occurred in 9% (14/145) of the cases. In the 1‐year follow‐up SCr returned to baseline values in 10 patients (71 %), 3 patients died (21%), and 1 patient had a major cardiovascular event (7%). No patients required dialysis. The risk was independent of chronic kidney disease stage. The rate of contrast nephropathy in each stage (X = 0.27) was as follows: 3/20 (15%) in stage 2; 3/66 (4.6%) in stage 3, 7/51 (13.7%) in stage 4; and 1/8 (12.5%) in stage 5. At the univariate analysis factors predicting this risk were anemia (HR 95% 2.5 [CI 1.8‐4.2] P = .039) and heart failure (HR 95% 2.6 [CI 2.1‐4.6] P = .038), while any significant variable was found at multivariate analysis.ConclusionsPeripheral percutaneous transluminal angioplasty in diabetic patients with CLI and FUs can be performed with a good safety factor and a low risk of contrast medium toxicity.
Phylogenetic congruence between subtropical trees and their associated fungi
Authors: Liu Xubing , Liang Minxia , Etienne Rampal S. , Gilbert Gregory S. , Yu Shixiao 
Published: October 2016

AbstractRecent studies have detected phylogenetic signals in pathogen–host networks for both soil‐borne and leaf‐infecting fungi, suggesting that pathogenic fungi may track or coevolve with their preferred hosts. However, a phylogenetically concordant relationship between multiple hosts and multiple fungi in has rarely been investigated. Using next‐generation high‐throughput DNA sequencing techniques, we analyzed fungal taxa associated with diseased leaves, rotten seeds, and infected seedlings of subtropical trees. We compared the topologies of the phylogenetic trees of the soil and foliar fungi based on the internal transcribed spacer (ITS) region with the phylogeny of host tree species based on matK, rbcL, atpB, and 5.8S genes. We identified 37 foliar and 103 soil pathogenic fungi belonging to the Ascomycota and Basidiomycota phyla and detected significantly nonrandom host–fungus combinations, which clustered on both the fungus phylogeny and the host phylogeny. The explicit evidence of congruent phylogenies between tree hosts and their potential fungal pathogens suggests either diffuse coevolution among the plant–fungal interaction networks or that the distribution of fungal species tracked spatially associated hosts with phylogenetically conserved traits and habitat preferences. Phylogenetic conservatism in plant–fungal interactions within a local community promotes host and parasite specificity, which is integral to the important role of fungi in promoting species coexistence and maintaining biodiversity of forest communities.
Interaction Between Orexin‐A and Sleep Quality in Females in Extreme Weight Conditions
Authors: Sauchelli Sarah , Jiménez‐Murcia Susana , Fernández‐García Jose C. , Garrido‐Sánchez Lourdes , Tinahones Francisco J. , Casanueva Felipe F. , Baños Rosa M. , Botella Cristina , Crujeiras Ana B. , de la Torre Rafael , Fernández‐Real Jose M. , Frühbeck Gema , Granero Roser , Ortega Francisco J. , Rodríguez Amaia , Zipfel Stephan , Giel Katrin E. , Menchón Jose M. , Fernández‐Aranda Fernando 
Published: October 2016

AbstractThe current study examined the relationship between plasma orexin‐A and sleep in obesity. Concentrations of orexin‐A and sleep were evaluated in 26 obese, 40 morbid obese and 32 healthy‐weight participants. The sleep monitor Actiwatch AW7 and the Pittsburgh Sleep Quality Index were used to evaluate sleep. The Symptom Checklist‐90‐Revised was administered to assess symptoms of psychopathology. A higher weight status was associated with elevated orexin‐A levels (p = .050), greater depression, anxiety and somatization symptoms (all: p < .001), and impoverished self‐reported sleep quality (p < .001). A quadratic trend was found in objective sleep time, being longest in the obese group (p = .031). Structural equation modelling showed plasma orexin‐A to be related to poor total sleep quality, which in turn was associated with elevated body mass index. Our data confirm an interaction between elevated plasma orexin‐A concentrations and poor sleep that contributes to fluctuations in body mass index. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
Comparison of a non‐stationary voxelation‐corrected cluster‐size test with TFCE for group‐Level MRI inference
Authors: Li Huanjie , Nickerson Lisa D. , Nichols Thomas E. , Gao Jia‐Hong 
Published: October 2016

AbstractTwo powerful methods for statistical inference on MRI brain images have been proposed recently, a non‐stationary voxelation‐corrected cluster‐size test (CST) based on random field theory and threshold‐free cluster enhancement (TFCE) based on calculating the level of local support for a cluster, then using permutation testing for inference. Unlike other statistical approaches, these two methods do not rest on the assumptions of a uniform and high degree of spatial smoothness of the statistic image. Thus, they are strongly recommended for group‐level fMRI analysis compared to other statistical methods. In this work, the non‐stationary voxelation‐corrected CST and TFCE methods for group‐level analysis were evaluated for both stationary and non‐stationary images under varying smoothness levels, degrees of freedom and signal to noise ratios. Our results suggest that, both methods provide adequate control for the number of voxel‐wise statistical tests being performed during inference on fMRI data and they are both superior to current CSTs implemented in popular MRI data analysis software packages. However, TFCE is more sensitive and stable for group‐level analysis of VBM data. Thus, the voxelation‐corrected CST approach may confer some advantages by being computationally less demanding for fMRI data analysis than TFCE with permutation testing and by also being applicable for single‐subject fMRI analyses, while the TFCE approach is advantageous for VBM data. Hum Brain Mapp 38:1269–1280, 2017. © 2016 Wiley Periodicals, Inc.
Benchmarking Judgmentally Adjusted Forecasts
Authors: Franses Philip Hans , de Bruijn Bert 
Published: October 2016

AbstractMany publicly available macroeconomic forecasts are judgmentally adjusted model‐based forecasts. In practice, usually only a single final forecast is available, and not the underlying econometric model, nor are the size and reason for adjustment known. Hence, the relative weights given to the model forecasts and to the judgement are usually unknown to the analyst.This paper proposes a methodology to evaluate the quality of such final forecasts, also to allow learning from past errors. To do so, the analyst needs benchmark forecasts. We propose two such benchmarks. The first is the simple no‐change forecast, which is the bottom line forecast that an expert should be able to improve. The second benchmark is an estimated model‐based forecast, which is found as the best forecast given the realizations and the final forecasts. We illustrate this methodology for two sets of GDP growth forecasts, one for the USA and one for the Netherlands. These applications tell us that adjustment appears most effective in periods of first recovery from a recession. Copyright © 2016 John Wiley & Sons, Ltd.
BUILDING CAPACITY IN REFLECTIVE PRACTICE: A TIERED MODEL OF STATEWIDE SUPPORTS FOR LOCAL HOME‐VISITING PROGRAMS
Authors: Watson Christopher L. , Bailey Ann E. , Storm Karen J. 
Published: October 2016

ABSTRACTThis preliminary study examines an initiative to further develop capacity in reflective practice among public health home visitors and their supervisors. A Maternal, Infant, and Early Childhood Home Visiting (MIECHV) Expansion Grant to the Minnesota Department of Health funded the development of a tiered structure to support reflective practice within county public health agencies throughout the state. Study data revealed a general consensus among individuals at all levels of the county programs that state supports were adequate to implement reflective practice. Although there were no significant changes in home‐visitor and supervisor scores on a standardized measure linked to reflective functioning and reflective practice, a majority of home visitors and supervisors perceived that their knowledge and skills in reflective practice had increased during the evaluation period. A standardized measure of employee burnout did not reveal significant changes in either “depersonalization” (indicating burnout) or “personal accomplishment” (a mitigating factor in burnout) subscales; however, home visitor “emotional exhaustion” subscale scores did increase over the evaluation period. In contrast to the subscale results, home visitors reported a sense of accomplishment in their reflective work and that they value “releasing” emotions in a safe environment during reflective supervision.
Multimodal Literacies: Imagining Lives Through Korean Dramas
Authors: Kim Grace MyHyun , Omerbašić Delila 
Published: October 2016

AbstractGlobal networks of information and interactions have created new conditions for access to myriad literacies, languages, and communities. Engagements with transnational texts and communities can support the imagination of lives different from one's local context. This article presents data from two qualitative studies of adolescent literacy practices about popular‐culture texts produced in Korea. Although these adolescents did not reside in Korea, the authors found that they constructed transnational spaces through these multimodal literacy practices: imagining different lives and engaging in multilingual mediascapes. Adolescents in both studies expressed a sense of belonging not exclusive to their places of residence. The findings support the argument that multimodal literacy practices developed through engagement with another country's popular‐culture texts support imaginative identity construction. These findings have implications for researchers and educators interested in multimodal literacies, digitally mediated learning, multilingualism, and transnational studies.
Low skeletal muscle radiation attenuation and visceral adiposity are associated with overall survival and surgical site infections in patients with pancreatic cancer
Authors: van Dijk David P. J. , Bakens Maikel J. A. M. , Coolsen Mariëlle M. E. , Rensen Sander S. , van Dam Ronald M. , Bours Martijn J. L. , Weijenberg Matty P. , Dejong Cornelis H. C. , Olde Damink Steven W. M. 
Published: October 2016

AbstractBackgroundCancer cachexia and skeletal muscle wasting are related to poor survival. In this study, quantitative body composition measurements using computed tomography (CT) were investigated in relation to survival, post‐operative complications, and surgical site infections in surgical patients with cancer of the head of the pancreas.MethodsA prospective cohort of 199 patients with cancer of the head of the pancreas was analysed by CT imaging at the L3 level to determine (i) muscle radiation attenuation (average Hounsfield units of total L3 skeletal muscle); (ii) visceral adipose tissue area; (iii) subcutaneous adipose tissue area; (iv) intermuscular adipose tissue area; and (v) skeletal muscle area. Sex‐specific cut‐offs were determined at the lower tertile for muscle radiation attenuation and skeletal muscle area and the higher tertile for adipose tissues. These variables of body composition were related to overall survival, severe post‐operative complications (Dindo–Clavien ≥ 3), and surgical site infections (wounds inspected daily by an independent trial nurse) using Cox‐regression analysis and multivariable logistic regression analysis, respectively.ResultsLow muscle radiation attenuation was associated with shorter survival in comparison with moderate and high muscle radiation attenuation [median survival 10.8 (95% CI: 8.8–12.8) vs. 17.4 (95% CI: 14.7–20.1), and 18.5 (95% CI: 9.2–27.8) months, respectively;P < 0.008]. Patient subgroups with high muscle radiation attenuation combined with either low visceral adipose tissue or age <70 years had longer survival than other subgroups (P = 0.011 andP = 0.001, respectively). Muscle radiation attenuation was inversely correlated with intermuscular adipose tissue (rp = −0.697,P < 0.001). High visceral adipose tissue was associated with an increased surgical site infection rate, OR: 2.4 (95% CI: 1.1–5.3;P = 0.027).ConclusionsLow muscle radiation attenuation was associated with reduced survival, and high visceral adiposity was associated with an increase in surgical site infections. The strong correlation between muscle radiation attenuation and intermuscular adipose tissue suggests the presence of ectopic fat in muscle, warranting further investigation. CT image analysis could be implemented in pre‐operative risk assessment to assist in treatment decision‐making.
Subdecadal‐scale vegetation responses to a previously unknown late‐Allerød climate fluctuation and Younger Dryas cooling at Lake Meerfelder Maar (Germany)
Authors: Engels Stefan , Brauer Achim , Buddelmeijer Nico , Martín‐Puertas Celia , Rach Oliver , Sachse Dirk , van Geel Bas 
Published: October 2016

ABSTRACTLake Meerfelder Maar (MFM) is the northernmost Western European sediment record with annual laminations across the Younger Dryas (YD), and the onset of the YD in the record of MFM has previously been defined as an increase in non‐arboreal pollen abundance at ca. 12 680 varve a BP. Here we present a palynological record at unprecedented subdecadal resolution for MFM, covering the Allerød–YD transition. Our results show a fluctuation in pollen accumulation rates (PARs) before the onset of the YD, with lower rates between ca. 12 725 and 12 685 varve a BP. The fluctuation in PARs occurs simultaneous with a previously undescribed short fluctuation in sediment composition and varve thickness, as well as with changes in biogeochemical proxies. The combined evidence indicates signs of climatic instability ca. 45 years before the onset of the YD. The PAR records of Betula and Pinus furthermore show earlier and more abrupt changes at the onset of the YD than the percentage‐records do. Finally, heliophilous herbaceous taxa show a delayed increase following the onset of the YD of ca. 145 years. This paper illustrates the potential to identify previously unrecognized climate variability and vegetation change when using subdecadal‐resolution analyses.
A refined paleotemperature calibration for New Zealand limnic environments using differentiation of branched glycerol dialkyl glycerol tetraether (brGDGT) sources
Authors: Zink K.‐G. , Vandergoes M. J. , Bauersachs T. , Newnham R. M. , Rees A. B. H. , Schwark L. 
Published: October 2016

ABSTRACTBranched glycerol dialkyl glycerol tetraethers (brGDGTs) were abundant in surface sediments of freshwater lakes and in catchment soils at altitudes from 10 to 2020 m in New Zealand. Significant differences in brGDGT compositions between lake sediments and soils indicate sources from separate microbial habitats. An expanded modern calibration dataset comprising 33 lakes has enabled a revised calibration function for determining past mean annual air temperature (MAT) from brGDGTs in New Zealand lake sediments: MAT (°C) = −31.664 × MBTm + 16.252 (n = 30). The function uses a modified methylation index of branched tetraethers (MBTm) that incorporates brGDGT III in the numerator to overcome the lower correlation found between our larger dataset and the unmodified MBT which had been used for previous calibrations. Calibrations combining the cyclization index of branched tetraethers (CBT) and the MBTm or using only certain brGDGTs are possible but have limitations. The revised function shows slightly higher correlation with MAT (R2 = 0.75) than previous calibrations, which were based on nine sites. The refined calibration function is applied to a ∼16 000‐year lake sediment sequence from northern South Island, New Zealand, and yields temperature reconstructions that are consistent with independently derived climate trends from the same sequence.