bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract A118: Barriers and facilitators to cervical cancer screening among older Hispanic women living in San Antonio, TX
Authors: Vázquez-Otero Coralia , Cordova Audrey , Pedraza Rita , Baglini Selena , Ramírez Amelie G. 
Published: September 2024

Abstract
Background: Disparities among Hispanic women getting screened for cervical cancer compared to non-Hispanic White women continue to exist, despite Hispanic women having higher incidence and mortality rates of cervical cancer. Previous work has shown limited knowledge and awareness about cervical cancer and screening, low health literacy, and cultural aspects such as fatalism as barriers to screening. On the other hand, having health insurance, a family history of cervical cancer and religiosity have been found to facilitate cervical cancer screening among Hispanic women. Moreover, in Texas, research has shown that women older than 50 and Hispanic women have lower rates of screening. Methods: Informed by the social determinants of health framework, we are interviewing Hispanic women living in San Antonio, TX about their experiences regarding cervical cancer screening. Questions cover the areas of knowledge about cervical cancer and cervical cancer screening, and barriers and facilitators to cervical cancer screening. We have completed 11 out of 36 planned interviews. Data analysis is guided by applied thematic analysis techniques. Preliminary Results: Currently, ages range from 50 to 64 years old. Most women are married and half are retired. Preliminary analysis shows continued low levels of knowledge about cervical cancer and screening. Barriers include feelings of fear and embarrassment about the test, physician’s gender, and access to healthcare, such as issues with transportation. Facilitators include physician’s attitude, clinic reminders, and having health insurance. Conclusion: More research is needed to understand and address barriers and facilitators to cervical cancer screening in this age group. Targeted public health efforts, including educational and multilevel interventions, should continue to increase knowledge about cervical cancer, and acceptability and access to cervical cancer screening among older Hispanic women living in San Antonio, TX.
Citation Format: Coralia Vázquez-Otero, Audrey Cordova, Rita Pedraza, Selena Baglini, Amelie G. Ramírez. Barriers and facilitators to cervical cancer screening among older Hispanic women living in San Antonio, TX [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A118.
Abstract A156: Cervical cancer knowledge and attitudes towards self-sampling and community health worker-delivered screening services across racial groups in Indiana
Authors: Babu Mrithula Suresh , Kasting Monica L , Rodriguez Natalia M. 
Published: September 2024

Abstract
Introduction – In Indiana, Black women had 12 percent higher cervical cancer incidence and 21 percent higher mortality compared to White women during the years 2008 to 2017. HPV self- sampling delivered by community health workers (CHW) could increase cervical cancer screening rates among at-risk populations. This study aims to compare cervical cancer knowledge, screening practices and attitudes towards HPV self-sampling and CHW-delivered screening services across racial groups. Methods – We conducted a cross-sectional online survey among patients from three Planned Parenthood clinics in Lake County, IN, which has one of the highest cervical cancer mortality rates in Indiana. A comparative analysis across racial groups based on their willingness to self-sample, receive health education and other services from CHWs was conducted using logistic regression analyses. Results – In the final sample (N=140), the largest proportions were below age 30 (54.3%), aware of cervical cancer (78.6%), up-to-date on cervical cancer screening (84.3%), had no prior self-sampling experience (53.6%) and were aware of CHWs (52.1%). The Black (M=3.97, SD=1.94) population had a lower mean score for cervical cancer knowledge compared to the White population (M=4.67, SD=2.01). Multivariable logistic regression analyses showed Black patients had higher odds of being willing to self-sample at home (aOR=3.749, 95%CI=1.619-8.681), to receive health education from CHWs (aOR=4.952, 95%CI=2.124-11.548) and to receive health services from CHWs (aOR=3.305, 95%CI=1.479-7.388) compared to White patients. Patients with higher knowledge (aOR=1.245, 95%CI=1.009-1.535) and patients overdue for screening (aOR=3.674, 95%CI=1.077-12.538) had higher odds of being willing to self-sample at home. Conclusion – The results showed Black patients had lower cervical cancer knowledge but higher acceptability of HPV self-sampling and CHW delivery of cervical cancer screening services. Study findings can be used to inform future CHW-led interventions for outreach, education, and delivery of self-sampling interventions to increase cervical cancer screening rates among Black women.
Citation Format: Mrithula Suresh Babu, Monica L Kasting, Natalia M. Rodriguez. Cervical cancer knowledge and attitudes towards self-sampling and community health worker-delivered screening services across racial groups in Indiana [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A156.
Abstract A162: The influence of parental barriers to healthcare on adolescent HPV vaccination uptake and completion among Latinos in Los Angeles
Authors: Kane Anju F. , Baezconde-Garbanati Lourdes 
Published: September 2024

Abstract
Objective: This study aims to investigate the association between parental barriers to healthcare access and HPV vaccination uptake among Latino adolescents in Los Angeles. Background: Human papillomavirus (HPV) induced cervical cancer (CC) remains a significant public health concern. Routine HPV vaccination has been recommended in the United States for girls since 2006 and boys since 2011 yet disparities in vaccine initiation and completion persist, particularly among Latino adolescents in Los Angeles. Methods: This cross-sectional study analyzed child data provided by mothers recruited from the Es Tiempo campaign (2016-2018). A total of 353 Latino adolescents aged 9 to 26 years were included in the sample. We used crosstabs to assess vaccine initiation and completion differences by child sex and birth order, while logistic regression models were used to evaluate the association between parental barriers to healthcare, such as lack of health insurance and access to a primary care provider (PCP), and HPV vaccination initiation. Results: Among the sample, 44% initiated the HPV vaccine, and 23% completed the series, with significantly higher rates among girls and firstborn children. Regarding barriers, lack of health insurance was associated with decreased odds of HPV vaccination uptake while access to a PCP showed a slight increase in vaccination uptake odds. Conclusion: HPV vaccination uptake among Latino adolescents in Los Angeles remains suboptimal, with disparities observed by gender and birth order. To improve public health outcomes, targeted interventions are needed to increase HPV vaccination uptake among Latino adolescent boys, and further research is needed to understand vaccine adherence patterns within families and among siblings. Moreover, while parental barriers to healthcare may influence vaccination uptake, future studies should also explore how factors like parental education level and socioeconomic status influence HPV vaccination status in combination with access barriers.
Citation Format: Anju F. Kane, Lourdes Baezconde-Garbanati. The influence of parental barriers to healthcare on adolescent HPV vaccination uptake and completion among Latinos in Los Angeles [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A162.
Abstract B010: Design of personalized neoantigen mRNA vaccines against breast cancer patients in Pakistan based on next-generation sequencing data
Authors: Raheem Kayode Yomi , Muddassar Muhammad 
Published: September 2024

Abstract
Breast cancer is the most common malignancy among women in Pakistan, with an outrageous increase in the incidence and mortality rate. Because of decreased effectiveness and lower survival rates, there is an urgent need for developing novel, personalized vaccines with enhanced activity. The development of a personalized mRNA vaccine illustrates a promising approach to combating the prevalence of breast cancer. We used the whole exome sequencing (WES) data of Pakistani tumor samples to predict immunogenic neoantigens. The WES data was aligned to the GRCM39 reference genome using BWA. The genome analysis toolkit (GATK) was employed for variant calling to identify somatic mutations. Using immune-bioinformatics tools, we predicted cytotoxic CD8+ T cell epitopes and helper CD4+ T cell epitopes within the identified neoantigens and designed vaccines by assembling the fusion of CTL neoepitopes, helper sequences, and adjuvants together with linkers. The Insilco ImmSim algorithm was used to examine the immune responses of the vaccine. The vaccine design was further explored by checking its simulation effect on the immune system, its physiochemical characteristics, its binding to specific immune system molecules, and cloning into an appropriate vector. In addition, molecular docking, MD simulation, and binding free energies were performed to investigate the interaction mechanism between the construct vaccine and Toll-like receptors (TLR2, TLR4, TLR7, and TLR9).By examining these factors, we aimed to ensure the vaccine's safety, stability, and ability to bind tightly to specific immune cells (class I MHC molecules), ultimately triggering a comprehensive immune response against breast cancer cells.
Citation Format: Kayode Yomi Raheem, Muhammad Muddassar. Design of personalized neoantigen mRNA vaccines against breast cancer patients in Pakistan based on next-generation sequencing data [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B010.
Abstract B033: Understanding Latinas’ decisions to participate in a unique breast cancer clinical trial: A qualitative constructivist grounded theory study
Authors: Ridley-Merriweather Katherine E. , Vogel Katherine 
Published: September 2024

Abstract
Background & Objective: Breast cancer is the most common cause of cancer death in Latinas in the United States; however, researchers often fail to use recruitment messaging targeted toward increasing Latina participation. Although the cancer disparities observed among this population are significant, these group members account for only 1.3% of cancer-related clinical trial participants in the United States. The barriers preventing Latinas’ participation in research are well-established, but there are few studies focused on comprehending the motivations of Latinas who previously volunteered for clinical trial participation. The aims of this study were to improve the understanding of Latinas’ decisions to participate in a unique breast cancer clinical trial and to propose future methods for increasing these group members’ motivations regarding medical research participation. Methods: Guided by constructivist grounded theory, twenty women (N= 20) who self-identified as Latina or Hispanic, and who had previously donated healthy breast tissue to a biobank that was part of a clinical trial, were interviewed regarding their medical research participation decisions. Participants were recruited through direct email and interviews were conducted over Zoom and Microsoft Teams. Results: Findings revealed three primary themes: (1) the availability of both bilingual recruitment materials and research team personnel were viewed as important motivators to participate, (2) the knowledge of their underrepresentation in medical research and the understanding that their participation may help Latinas in the future were revealed as important motivators to participate, and (3) individuals who received negative feedback from family and/or friends about their intended research participation remained resolute in their decision to donate tissue. Conclusions: Understanding the motivations of Latinas who have previously participated in cancer-related clinical trials can help researchers create targeted and/or tailored recruitment messaging. Messaging must emphasize the consequences of underrepresentation of Latinas in clinical trials, be bilingual, and communicate that participation in cancer clinical trials can positively impact the health of other Latinas in the future.
Citation Format: Katherine E. Ridley-Merriweather, Katherine Vogel. Understanding Latinas’ decisions to participate in a unique breast cancer clinical trial: A qualitative constructivist grounded theory study [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B033.
Abstract B103: Friend-to-friend: Culturally tailored health education for East African communities
Authors: Abbenyi Adeline , Abbadi Manal , Ali Khadija , Ahmed Fatuma 
Published: September 2024

Abstract
Purpose: The Mayo Clinic Comprehensive Cancer Center (MCCCC) serves its communities through every pillar of the cancer continuum from prevention to survivorship. To effectively educate our communities along this continuum, MCCCC partnered with a trusted community partner, leveraged the stories of survivors, and addressed stigma in a safe space for community members to ask vulnerable questions. Methods: The MCCCC partnered with Pamoja Women on the Friend-to-Friend initiative. Pamoja Women is a trusted community partner supporting East African women and their families, some of whom are refugees. They provided the space to hold each event, an environment where the women were comfortable with support from their community. The program highlighted cancer education, screening, and risk reduction through culturally appropriate discussions between friends. Topics were identified based on community interest and the cancer incidence in the community. Survivors shared their personal stories and medical experts discussed prevention, risk reduction, screening, addressed myths, answered questions, and showcased discoveries in research and treatment methods. Results: We have held 3 events covering breast, cervical, and HPV vaccination. Each event saw an increase in participation with almost 50 participants attending the series. Furthermore, there was an increase in awareness of screening methods, prevention, and risk reduction. Pamoja Women provided navigation to screening through transportation to and advocacy during appointments. This continuity from education to screening led to heading the call to action for screening. Due to its success, the four-part series has been expanded to include the topics of endometrial, prostate cancer, and breast cancer for a second time. Conclusion: Partnering with trusted community organizations has led to safe spaces for cancer education with friends. This approach has led to successful education and navigation to screening in communities that do not always have access to this essential information.
Citation Format: Adeline Abbenyi, Manal Abbadi, Khadija Ali, Fatuma Ahmed. Friend-to-friend: Culturally tailored health education for East African communities [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B103.
Abstract B134: Socioeconomic, social, and clinical factors associated with loneliness among African American breast cancer survivors
Authors: Campbell Kelsie , Sanogo Fatimata , Beard Trista , Jefferson Melanie , Sahlia Bodhour , Halbert Chanita Hughes 
Published: September 2024

Abstract
Importance: Social connections are an important driver of cancer risk and outcomes and animal studies have shown that social isolation is important to breast cancer initiation and progression. However, limited empirical data are available on perceived loneliness among patient groups who are at increased risk for breast cancer morbidity and mortality. Objectives: The purpose of this study was to characterize the nature and distribution of loneliness in a sample of African American breast cancer patients and identify clinical and social factors having significant independent associations with perceived loneliness among these survivors. Methods: The study included African American breast cancer patients (n=110) who provided self-reported data on loneliness as part of a participating in a prospective observational study and randomized trial that examined stress reactivity using the Trier Social Stress Test. Loneliness was measured using a short form of the Loneliness Scale; scores were dichotomized using the median split to characterize patients as experiencing high versus low levels of loneliness. Multivariate logistic regression analysis was used to identify factors having significant associations with loneliness. Results: Over half (51.82%) of patients reported experiencing high levels of loneliness. Clinical and social factors that had significant independent associations with loneliness included marital status (OR=2.853, CI=1.066, 7.635, p=0.037), financial strain (OR=3.240, CI=1.114, 9.422, p=0.031), and the number of co-morbidities. Compared to patients who did not have any co- morbidities, those who had one, two, or three or more comorbidities had seven (CI=1.066, 40.645; p=0.029), eleven (CI=1.858, 66.716, p=0.008), and eleven (CI=1.757, 65.244; p=0.010) times the odds, respectively, of experiencing loneliness. Conclusions and Relevance: Many African American breast cancer patients in this study reported high levels of loneliness. Greater efforts are needed to identify patients who may benefit from interventions that enhance social connections, especially if they are married, experiencing financial strain, and have co-morbid conditions.
Citation Format: Kelsie Campbell, Fatimata Sanogo, Trista Beard, Melanie Jefferson, Bodhour Sahlia, Chanita Hughes Halbert. Socioeconomic, social, and clinical factors associated with loneliness among African American breast cancer survivors [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B134.
Abstract B146: Themes of importance among underrepresented men with prostate cancer: CEASAR 2.0
Authors: Murray Nicole , Horns Joshua J. , Chipman Jonathan , Sokeye Joshua , O'Neil Brock 
Published: September 2024

Abstract
Background: The etiology regarding why men of underserved populations experience worse health outcomes is multifaceted and complex. Due to social and economic issues, underrepresented men may be choosing to undergo less curative treatment options. Materials and Methods: The Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study is a prospective cohort study which is uncovering decision drivers to prostate cancer (PCa) treatment among low risk prostate cancer patients (n=3691). A subset of CEASAR participants were contacted for qualitative interviews and questionnaires (n = 66). Phone interviews were conducted from November 2020 and August 2021 by the CEASAR research team. Interviews were transcribed, and themes of importance were analyzed from patients who were considered to be low SES background and/or racially and ethnically minoritized patients. Results: Overall 24% (n=16) of CEASAR patients who completed qualitative interviews were of low SES background and/or racially and ethnically minoritized. Three themes of importance emerged from of underserved men: financial toxicity 25% (n = 4/16), role as a primary caregiver 13% (n = 2/16), and lack of cultural acceptability 19% (n = 3/16). Discussion: Although most men within the CEASAR study were highly educated and had access to resources, qualitative work suggests there may be different aspects of care that impact a subset of underserved prostate cancer survivors. Financial toxicity, serving as a primary caregiver, and lack of cultural acceptability may serve as contributors to the decisions of underserved men with PCa. This may help explain worse health outcomes among these survivors. Conclusion: Socioeconomic factors regarding underrepresented men with PCa’s decision to undergo less curative treatment, is poorly understood in the literature. In this longitudinal prospective cohort study, we were able to identify three themes of importance contributing to underrepresented men’s decision making around PCa treatment. Further investigation exploring barriers to care among underserved men with PCa is needed to determine effective treatment regimen for these patients that experience worse outcomes.
Citation Format: Nicole Murray, Joshua J. Horns, Jonathan Chipman, Joshua Sokeye, Brock O'Neil. Themes of importance among underrepresented men with prostate cancer: CEASAR 2.0 [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B146.