bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination of Erythropoietin and Tranexamic Acid in Bilateral Simultaneous Total HIP Arthroplasty: A Randomised, Controlled Trial
Authors: Wu Yuan-gang , Zeng Yi , Shen Bin , Si Hai-bo , Cao Fei , Yang Ti-min , Pei Fu-xing 
Published: April 2016

Introduction This study aimed to evaluate whether the combination of erythropoietin (EPO) and tranexamic acid (TXA) exerted any additional benefits on the number of blood transfusions required and haematological parameters compared with TXA alone following primary bilateral simultaneous total hip arthroplasty. Materials and methods We conducted a single-centre, prospective, randomised, and controlled trial at our hospital. Group EPO + TXA (n = 30) received daily subcutaneous injections EPO (10,000 IU) on preoperative days 1-4 and postoperative days 1-3. Additionally, these patients were administered TXA (15 mg/kg) 10 min prior to the incision. Group TXA (n = 32) received only TXA (15 mg/kg) 10 min prior to the incision. The primary outcomes were the haematological parameters and number of blood transfusions required. The secondary outcomes were total blood loss, drainage volume, and postoperative complications. Results The total amount of blood transfusion and mean blood transfusion per patient was lower in group EPO + TXA than in group TXA (p = 0.039, p = 0.023; respectively). In the postoperative period, patients in group EPO + TXA had higher haematological parameters (haemoglobin, haematocrit, and reticulocyte count) than patients in group TXA. No significant differences were found in total blood loss, drainage volume, and DVT or PE between the 2 groups. Conclusions This study showed that administrating EPO + TXA in combination can increase haematological parameters and reduce the need for blood transfusion without increasing the risk of DVT or PE compared with TXA alone.
The Prevalence of Radiographic Signs of Pincer Type Morphology in a Population Based Cohort Study of Asymptomatic Japanese
Authors: Mochizuki Yoshihito , Kokubo Yoshiyasu , Yamazaki Takashi 
Published: April 2016

Background This study was designed to document the prevalence of radiographic findings of pincer-type morphology in an asymptomatic population and determine any relationship to age. Methods A total of 2,104 hips in 1,052 patients (mean age 38.9 years [10-59]), who underwent abdominal/pelvic computed tomography for other conditions, were identified retrospectively. Anteroposterior scout radiographs were used to detect the acetabular crossover sign (COS), prominent ischial spine (PRIS), coxa profunda (CP), and posterior wall sign (PWS). Subgroup analyses of signs were performed by age (group 1: 532 hips in <30-year-old patients; group 2: 1,572 hips in ≥30-year-old patients). Results COS and PRIS was observed significantly more often in group 1 vs. group 2: COS was 73.1% vs. 29.3% in group 2, p<0.001; PRIS was 23.9% vs.7.4% in group 2, p<0.001. CP and PWS was observed significantly less frequently in group 1 vs. group 2: CP 3.4% vs. 21.2% in group 2, p<0.001; PWS was 4.7% vs. 11.0% in group 2, p<0.001. Discussions Radiographic pincer-type findings were common in an asymptomatic population and their prevalence was dependent upon a patient's age, indicating a diagnosis using radiographic parameters should also take into account a patient's age.
Stem Anteversion Affects Periprosthetic Bone Mineral Density after Total HIP Arthroplasty
Authors: Hayashi Shinya , Hashimoto Shingo , Kanzaki Noriyuki , Kuroda Ryosuke , Kurosaka Masahiro 
Published: April 2016

Aims The present study aimed to evaluate periprosthetic bone mineral density (BMD) changes around a cementless short tapered-wedge stem used for total hip arthroplasty (THA) and to determine the correlation between BMD changes and stem alignment after THA. Methods The study included 21 patients (21 joints) who underwent THA with a TriLock stem. At baseline and 6, 12, 18, and 24 months postoperatively, the BMDs in the 7 Gruen zones were evaluated using dual-energy X-ray absorptiometry. BMD changes and stem alignment, that is, anteversion, varus, and anterior tilt, were correlated. Results Minimal BMD changes were found in the distal femur (Gruen zones 3, 4, and 5), but significant BMD loss was noted in zone 7. BMD loss was also noted in zone 1 at 6 and 12 months postoperatively, but it recovered after 18 months. No correlation was found between BMD changes and anterior tilt. However, significant negative correlations were found between BMD changes and anteversion. Furthermore, significant negative correlations were found between BMD changes and varus in Gruen zone 1, while positive correlations were found between BMD changes and varus in Gruen zone 7. Conclusions We demonstrated that periprosthetic BMD was well maintained in the proximal femur after THA with a short tapered-wedge stem and that stem anteversion affects periprosthetic BMD after THA.
Mid-Term Comparative Outcomes of Autologous Bone-Marrow Concentration to Treat Osteonecrosis of the Femoral Head in Standard Practice
Authors: Cruz-Pardos Ana , Garcia-Rey Eduardo , Ortega-Chamarro Jose A. , Duran-Manrique David , Gomez-Barrena Enrique 
Published: April 2016

Purpose To evaluate mid-term effectiveness of core decompression (CD) followed by injection of bone-marrow concentration (BMC) in osteonecrosis of the femoral head (ONFH) compared with CD alone. Methods We retrospectively studied 60 hips in 45 patients with ONFH Ficat I-II after a mean follow-up of 45 (range 24-171) months. Group A (19 hips) were treated with CD, and Group B (41 hips) with CD plus autologous BMC. Necrotic lesions were classified according to MRI findings in: (i) the lesion angle; and (ii) the relation of the necrotic area to the weight-bearing portion. Outcomes included clinical changes and radiographic femoral head collapse. Risk factors associated with radiological collapse were evaluated by Cox regression analysis. Results Postoperative Merlé D'Aubigne and Postel hip score was similar in both groups. Femoral head collapse was observed in 10/19 hips in Group A and 22/41 in Group B. At 24 months, the probability of not having a collapse was 56.4% (95% CI, 33.6%-79.1%) for Group A and 57.6% (95% CI, 41.7%-73.4%) for Group B (p = 0.47). The risk of collapse increased in hips with a lesion angle higher than 150° (p<0.02, hazard risk [HR] 4.073) in both groups. Conclusions With the standard BMC technique performed without monitoring the number of progenitors in the concentrate, we are uncertain to observe a significant decrease in femoral head collapse compared to CD alone. Improved outcomes may require the monitoring of progenitor cells injected into the femoral head, particularly in large lesions.
The Effect of Continuous Elimination Methods on the Hemostatic Profile of a Cardiac Surgery Patient Monitored using Thromboelastography
Authors: Zuščich Ondřej , Hájek Roman , Ševčík Pavel , Lonský Vladimír , Zapletalová Jana 
Published: April 2016

Introduction This work is focused on mapping issues of hemostasis in patients during continuous renal replacement therapy, or the possible impact of the use of anticoagulants. Methods The study included 30 consecutive patients requiring continuous renal replacement therapy following cardiac surgery in the period of 2009 to 2012. Patients were placed into 2 branches according to the selected method of anticoagulation (regional citrate anticoagulation-RCA, unfractionated heparin UFH). According to the given scheme (t1–t7) thromboelastography and laboratory testing related to the testing of blood clotting during continuous renal replacement therapy were performed. Results The average lifespan of a hemofilter during continuous renal replacement is 58.13 ± 9.968 hours. During continuous renal replacement therapy there are significant changes in the initiation of coagulation according to thromboelastographic parameters (R, K, alpha angle) in both branches of anticoagulation. The maximum image changes in hemostasis occur around 24 hours (t4) from the start of the procedure. The nature of the changes is the procoagulant activity in these parameters. In the branch of regional citrate anticoagulation a higher value of functional fibrinogen is apparent. There was no significant difference in the activation of native blood between UFH and RCA. Conclusions During continuous renal replacement therapy significant changes occur in the thromboelastographic image and the laboratory parameters in blood clotting. The nature of the change is the procoagulant activity. The question remains about the complexity of the changes that TEG is not able to detect, especially in the cellular area.
Clinicopathological Significance and Diagnostic Accuracy of HER2 Immunohistochemistry in Colorectal Cancer: A Meta-Analysis
Authors: Pyo Jung-Soo , Kang Guhyun , Park Kyeongmee 
Published: April 2016

Introduction The aim of this study was to elucidate the clinicopathological significance of HER2 expression and the diagnostic accuracy of HER2 immunohistochemistry (IHC) in colorectal cancer (CRC). A total of 2,573 CRC cases from 13 eligible studies were included. Methods We performed a meta-analysis to examine the correlations between HER2 expression and clinicopathological characteristics in CRC. Concordance analysis between HER2 IHC and in situ hybridization (ISH) and diagnostic test accuracy review was conducted. Results The estimated rate of HER2 IHC overexpression was 0.162 (95% confidence interval [CI] 0.106-0.240). HER2 IHC overexpression was significantly correlated with lymph node metastasis and distant metastasis but not tumor depth. HER2 IHC overexpression was not correlated with overall survival. The concordance rates between IHC and ISH were 0.968 (95% CI 0.881-0.992), 0.377 (95% CI 0.225-0.557) and 0.780 (95% CI 0.390-0.952) for HER2 IHC scores of 0/1+, 2+ and 3+, respectively. The diagnostic test accuracy review of HER2 IHC revealed that the pooled sensitivity and specificity were 0.71 (95% CI 0.58-0.82) and 0.96 (95% CI 0.94-0.97), respectively. The diagnostic odds ratio and area under the summary receiver operating characteristic curve were 51.34 (95% CI 3.82-690.54) and 0.9704, respectively. Conclusions HER2 IHC overexpression was significantly correlated with lymph node metastasis and distant metastasis. CRC cases with HER2 IHC scores of 0/1+ exhibited good agreement with the ISH data. However, additional ISH analysis is needed to confirm HER2 status in cases with IHC scores of 2+ or 3+.
Role of Bacterial Contamination in Endometriosis
Authors: Khan Khaleque N. , Kitajima Michio , Fujishita Akira , Nakashima Masahiro , Masuzaki Hideaki , Kitawaki Jo 
Published: April 2016

The human lower genital tract is constantly exposed to various microorganisms, which can infect the upper genital tract through ascending migration. We report on tests of the hypothesis that as normal microbial flora in the vagina, some gram-negative bacteria infect the uterine wall after ascending migration from the vagina, to contaminate menstrual blood, consequently resulting in accumulation of endotoxin in the menstrual/peritoneal fluid and initiation of pelvic inflammation. The aim of the present review is to assess possible intrauterine microbial colonization and to examine the stimulatory effect of E. coli-derived lipopolysaccharide (LPS) on the secretion of various macromolecules by macrophages (Mϕ) known to be involved in endometriosis. We also assess the growth-promoting effect of LPS on endometrial cells and the role of Toll-like receptor 4 (TLR4), a receptor recognizing LPS, in the secretion of macromolecules by Mϕ and growth of endometrial cells. We found higher intrauterine microbial colonization in women with endometriosis than in controls. The ligand from gram-negative bacteria is involved in TLR4-mediated proinflammation in the pelvis as well as growth of endometriosis. Treatment with gonadotropin-releasing hormone agonist (GnRHa) further promotes intrauterine microbial colonization compared with GnRHa-untreated women. Conclusions We propose the bacterial contamination hypothesis as a new concept in endometriosis. Based on our current findings, an estrogen-suppressing agent and an antimicrobial agent may have new therapeutic potential in women with endometriosis.
Endometriosis and Crohn's Disease Side by Side: A Case Report
Authors: Paixão-Barradas Filipa P.M. , Sousa Vera , Pereira Daniela , Lopes Ana P. , Marques Isabel 
Published: April 2016

Endometriosis is the presence of ectopic endometrial tissue at extrauterine sites. Symptoms vary greatly and depend on the extent of the disease, ranging from an asymptomatic state to a miscellaneous group of symptoms. The correct diagnosis of intestinal endometriosis is often delayed because it may clinically masquerade as a wide spectrum of diseases, mainly Crohn's disease. We describe the case of a 42-year-old woman who presented to our hospital with subacute bowel obstruction. She had been suffering from strong abdominal disorders for over ten years with recurrent abdominal pain and chronic diarrhea, sometimes with gross bleeding, resulting in impaired nutrition, weight loss, and several hospital admissions. She had been diagnosed with Crohn's Disease ten years earlier, which was established by imaging, endoscopic and histologic criteria. The gastrointestinal symptoms were recurrent despite the medication for inflammatory bowel disease (IBD). The patient underwent a laparotomy, which identified a large bowel wall thickening with severe mucosal edema and luminal stricture in the proximal ileum. An ileocecal resection and appendectomy with latero-lateral ileocolic anastomosis was performed. Histopathological examination reported a diagnosis of ileocecal endometriosis. After a three-year follow-up period, she has no gynecologic symptoms but still maintains chronic diarrhea and imaging and endoscopic criteria are suggestive of IBD. Intestinal endometriosis should be borne in mind when a woman of reproductive age presents with episodic gastrointestinal symptoms. Multidisciplinary care should be encouraged.
Anti-hMAM Monoclonal Antibodies Evaluated in Breast and Non-Breast Tissues for Differential Diagnosis Implication
Authors: Lv Xiaojuan , Feng Xiaoyan , Hao Xiaopeng , Meng Di , Yang Xiqin , Xiu Bingshui , Chen Kun , Lu Yinglin , Zhang Heqiu , Zeng Yanjun , Huang Yan 
Published: April 2016

Purpose Human mammaglobin (hMAM) is a breast tissue-specific marker that may have potency for the diagnosis of breast cancer. However, there is a lack of commercialization of anti-hMAM antibody made in China. Methods Immunoreactivities of 2 self-made monoclonal anti-hMAM antibodies, MEF521 and MDA822, were evaluated by immunohistochemistry staining and compared with imported monoclonal antibody ab81611. A total of 48 cases of primary breast cancers, 36 cases of benign or normal breast tissues, 52 cases of lymph nodes or organ metastases from breast cancer, and 90 cases of non-breast primary carcinoma tissues were analyzed. Results All 3 anti-hMAM antibodies showed high positive expression of hMAM in primary breast cancers, benign, and normal breast tissues. The positive ratio for MEF521 (33.3%) or MDA822 (44.4%) was much higher than that of ab81611 (16.7%) in lymph node metastasis from breast cancer (p = 0.038). There was no correlation between hMAM expression and clinicopathologic features of breast cancer in the 3 groups of antibodies. In 90 cases of non-breast primary carcinoma tissues, no hMAM-positive ones were observed in the MEF521 or MDA822 group, but 48 (53.3%) in the ab81611 group were positive, indicating that breast tissue specificity of the 2 self-made anti-hMAM monoclonal antibodies much higher than that of ab81611 (p<0.001). Conclusions Our results showed that MDA822 and MEF521 are more specific to breast cancer as measured by means of immunohistochemistry. Therefore, the 2 self-made anti-hMAM antibodies may have good prospects for clinical application in the differential diagnosis of breast tumor and breast cancer metastases.
TAp73 and ΔNp73 Relative Expression in Egyptian Patients with Lymphoid Neoplasms
Authors: Hamdy Mona Salah Al-Din , El-Saadany Zainab Ali , Makhlouf Manal Mohamed , Salama Asmaa Ibrahim , Ibrahim Nihal Salah , Gad Alaa Amr 
Published: April 2016

Background and aims The p73 gene has different isoforms with opposing anti- and pro-apoptotic functions. The pro-apoptotic activities are inhibited by overexpression of the dominant ΔNp73 isoform. The aim of this study was to detect the expression of the TAp73 and ΔNp73 isoforms in Egyptian patients with malignant lymphoid neoplasms. Their expression was analyzed by quantitative RT-PCR. Patients and Methods The study included 30 B-NHL patients, 24 T-NHL patients, 16 ALL patients, 18 CLL patients, 22 patients with reactive lymphoid hyperplasia, and 6 healthy control subjects. Results ALL and CLL patients expressed both isoforms at higher levels compared to lymphoma patients. Higher expression of TAp73 was found in both B-NHL and T-NHL (around 4-fold and 16-fold, respectively) in comparison to ΔNp73 (2-fold and 14-fold, respectively). In CLL patients both isoforms showed higher expression levels in comparison to normal peripheral blood lymphocytes controls: nearly 27-fold for TAp73 and 233-fold for ΔNp73. All ALL patients showed higher expression of both studied isoforms than controls (9-fold for TAp73 and 386-fold for ΔNp73). The highest ΔNp73 expression along with a higher ΔNp73/TAp73 ratio (67-fold) was found in ALL patients compared with CLL patients (21-fold). Conclusions A considerable number of lymphoma patients lacked the expression of either or both isoforms, while all lymphoid leukemia patients expressed both isoforms. The expression pattern differences of p73 isoforms may reflect differences in the biology of these malignancies.
Penile Curvature: An Update for Management from 20 Years Experience in a High Volume Centre
Authors: Sasso Francesco , Vittori Matteo , D'Addessi Alessandro , Bassi Pier Francesco 
Published: April 2016

Our aim was to review the literature and discuss about penile curvature in order to have an update for management after 20 years experience in the field. Penile curvature may be congenital or acquired. Congenital penile curvature is a relatively uncommon condition that may present in late adolescent or early adult life. The incidence is estimated to be 0.6 %. On the other side, acquired penile curvature has an overall prevalence of 0.5-13%. Three main factors seem to increase the risk of developing an acquired penile curvature, often related to Peyronie's disease: penile traumatism, genetic and familiar conditions and a history of diseases of the genital tract. In treating Peyronie's disease, no medical therapy is fully effective, and surgery remains the gold standard in cases of severe deformity and/or erectile disfunction. Peyronie's disease is associated with significant psychological stress for patients and their partners. Appropriate treatment should be individualized and tailored to the patient's goals and expectations. There is not the ‘best’ surgical technique and outcomes are satisfactory when proper treatment decisions are made.
A Strong Law of Large Numbers for Set-Valued Negatively Dependent Random Variables
Authors: Guan Li , Wan Ying 
Published: April 2016

In this paper, we shall represent a strong law of large numbers (SLLN) for weighted sums of negative dependent set-valued random variables in the sense of the Hausdorff metric $d_{H}$, based on the result of single-valued random variable obtained by Taylor (Taylor, 1978).
Ruthenium redox equilibria: 1. Thermodynamic stability of Ru(III) and Ru(IV) hydroxides
Authors: Povar Igor , Spinu Oxana 
Published: April 2016

<p class="PaperKeywordTitle"><span lang="EN-US">On the basis of the selected thermodynamic data for Ru(III) and Ru(IV) compounds in addition to original thermodynamic and graphical approach used in this paper, the thermodynamic stability areas of sparingly soluble hydroxides as well as the repartition of their soluble and insoluble chemical species towards the solution pH and initial concentrations of ruthenium in heterogeneous mixture solid phase–saturated solution have been investigated. By means of the Δ<em>G</em>–pH diagrams, the areas of thermodynamic stability of Ru(III) and Ru(IV) hydroxides have been established for a number of analytical concentrations in heterogeneous mixtures. The diagrams of heterogeneous and homogeneous chemical equilibria have been used for graphical representation of complex equilibria in aqueous solutions containing Ru(III) and Ru(IV). The obtained results, based on the thermodynamic analysis and graphic design of the calculated data in the form of the diagrams of heterogeneous chemical equilibria, are in good agre­ement with the available experimental data. </span></p>
Strategies for Achieving Measurement Assurance for Cell Therapy Products
Authors: Simon Carl G. , Lin-Gibson Sheng , Elliott John T. , Sarkar Sumona , Plant Anne L. 
Published: April 2016

Abstract

The cell therapy industry has identified the inability to reliably characterize cells as possibly its greatest challenge and has called for standards and reference materials to provide assurance for measurements of cell properties. The challenges in characterization of cell therapy products can be largely addressed with systematic approaches for assessing sources of uncertainty and improving confidence in key measurements. This article presents the many strategies that can be used to ensure measurement confidence and discusses them in terms of how they can be applied to characterization of cell therapy products. Application of these strategies to cell measurements will help to establish qualified assays for cell characterization, which may help streamline regulatory approval and enable more efficient development of cell therapy products.

Significance
The regenerative medicine industry has identified the lack of reliable methods for measuring critical cell attributes as possibly the single greatest challenge facing the field. There are many strategies for achieving measurement assurance, or confidence in cell assays, which can streamline regulatory approval and enable more efficient development of cell-based therapies.
Tunable terahertz half-wave plate based on hybridization effect in coupled graphene nanodisks
Authors: Peng Jialong , Zhu Zhihong , Zhang Jianfa , Yuan Xiaodong , Qin Shiqiao 
Published: April 2016

Abstract
We demonstrate a tunable terahertz half-wave plate composed of a periodic array of graphene nanodisk dimers supported on a dielectric spacer backed by a planar gold layer. The polarization conversion phenomena are attributed to the hybridization effect caused by coupling interactions between plasmonic resonances in the graphene nanodisk dimers. By varying the distance between graphene nanodisks, the polarization conversion performance can be controlled. Further, the polarization conversion can be dynamically tuned at different frequencies via electrostatic doping of graphene. Other novel phenomena and applications could be developed from coupled graphene structures in the future.