bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profile of a group of Spanish-speaking self-changers from northern Spain and southern Florida (USA) / Perfil de un grupo de autocambiadores hispanohablantes del Norte de España y del Sur de Florida (EEUU)
Authors: Carballo José Luis , Fernández-Hermida José Ramón 
Published: November 2017

Los que abandonan o reducen el consumo de alcohol y otras sustancias. El objetivo de este trabajo fue analizar en población hispanohablante, los procesos, las circunstancias y las características que explican cómo y porqué los adictos a sustancias (alcohol y otras drogas) se recuperan sin solicitar ayuda profesional. Utilizando fundamentalmente anuncios de prensa, se reclutaron 54 autocambiadores hispanohablantes que llevabanal menos 1 año recuperados, de los cuales 29 fueron reclutados en España y 25 en el Sur de Florida (EEUU). A todos ellos se les evaluó en una única sesión en aspectos relacionados con la adicción y la recuperación.Los resultados mostraron que el autocambiador hispanohablante es fundamentalmente un varón de mediana edad, que ha tenido problemas en el pasado con el alcohol y que ha abandonado el consumo por razones de salud, sin acudir a tratamiento por no considerar su problema de gravedad. El perfil encontrado en este estudio de los participantes hispanohablantes es muy similar al encontrado en estudios previos con población no hispanohablante. Abstract Natural recovery has shown itself to be the most common form of recovery among those who give up or reduce the use of alcohol and other substances. The goal of the present work was to analyze in Spanish-speaking population the processes, circumstances and characteristics that explain how and why addicts to substances (alcohol and other drugs) recover without seeking professional help. Using mainly press advertisements, we recruited 54 Spanish-speaking self-changers who had recovered at least 1 year previously, 29 from Spain and 25 from southern Florida (USA). All participants were assessed in a single session on aspects related to addiction and recovery. The results showed that the Spanish-speaking self-changer is basically a middle-aged male, who has had problems in the past with alcohol and who has given it up for health reasons, without seeking treatment since he does not consider it a serious problem. The profile found in this study with Spanish-speaking participants is very similar to that found in previous studies with non-Spanish-speaking populations.
Next Generation Pour Point Depressants Based on Novel Polymer Modifications
Authors: Scherf Sabine , Boddien Dr. Albert 
Published: November 2017

Abstract
Current logistics and pipeline infrastructure limitations make waxy crude oil transportation and production challenging and require a step change in the chemistry required to mitigate crude oil composition issues. For wax prevention, usually pour point depressants (PPD) or wax inhibitors are applied. A new approach makes use of special hydrophobe modification in typical polymer systems, which significantly broadens their applicability. Commonly known PPD polymer systems have been modified with special branched and linear heavy alcohols following standard synthesis protocols. Pour point depressants, mostly solvent-based polymer mixtures, are sometimes applied to crude oil production and transportation systems in extreme environments where the viscosity and pour point of the PPD itself is critical. The work presents especially the introduction of heavy alcohols in combination with 2-alkyl branched long-chain alcohols in polymer systems. The performance of these newly hydrophobically modified PPDs were compared with standard polymer systems using laboratory test procedures like pour point, temperature dependent viscosity or yield stress by using model oil samples. The performance studies showed that by introducing the 2-alkyl branching into the polymer system, the overall performance of such PPDs will be boosted and the pour point of the PPD itself will be decreased drastically. These hydrophobe-modified polymer systems enables the production of liquid and high active PPDs containing long alkyl chains for enhanced interaction with the high carbon number paraffin of the waxy crude oils.
A Review of Good Practices During the Cementation of Challenging Long Liners
Authors: Hussain Al Mohammed Bader , Bottiglieri Antonio , Brandl Andreas 
Published: November 2017

Abstract
Some of the land fields in Middle East contain important potential gas reserves, but zonal isolation of long drilling and production liners have been a challenge. Cementing these long liners along formations with low fracture gradients risks formation breakdowns when exceeding the maximum allowable equivalent circulation densities. Consequences include severe losses, formation damage, and insufficient placement necessitating costly remedial cementing, or even loss of the well.
Many wells in one field were abandoned and not completed because of the tight pore-fracture pressure window, which induced severe losses while drilling the intermediate and production sections. Operators have struggled to mitigate those drilling challenges, and one of the last approaches was to use an ultra-slim hole design; however, this design exacerbated the cementing challenges for the long 7-in. liner. We review this case history and outline the corresponding planning (spacer/cement fluid designs, placement simulations, and lab test results), pre-job practices, and job execution with evaluation.
In this particular well, the 8 3/8-in. open hole section was drilled to the casing point with no losses. However, while running the 7-in. liner (at &gt; 10,000 ft) total losses occurred. A new design approach was developed and applied to mitigate the problems associated with cementing this section. This approach centered on the careful selection and engineering design of a spacer to cure and mitigate induced losses, and the use of high-performance cement slurries. Desirable properties of the latter include very low fluid loss and exceptional fluidity (low rheology) without development of free fluid or sedimentation. Finally the 7-in. liner was successfully cemented, and cement was found on top of the liner after reversing out.
A comprehensive approach on how to cure or reduce lost-circulation problems during cementing operations for critical sections (such as very long liners along fragile formations) are presented and discussed in this study. Case histories from several wells in the area are used to demonstrate the success of this approach with guidelines and lessons learned for similar upcoming projects.
Two-phase Surgery Using a Dermal Regeneration Material for Nail Unit Melanoma: Three Case Reports
Authors: Iino Shiro , Sato Suguru , Baba Natsuki , Maruta Naoki , Takashima Wataru , Oyama Noritaka , Kiyohara Takahiro , Yasuda Masato , Hasegawa Minoru 
Published: November 2017

Background:Nail unit melanoma (NUM) poses a considerable treatment challenge, particularly in cases with in situ or early invasive lesions, and wide excision with phalanx amputation. For post-excisional skin defects, stump plasty and/or split-thickness skin grafting may cause persisted irritation and ulceration as a post-operative complication, because of the insufficient underlying tissue volume, vascularity, and stability.Objective:To seek out other superior management avoiding disadvantages associated with the conventional NUM surgery.Method:Three consecutive cases with NUM were treated by a novel two-phase surgical procedure using a commercially available dermal regeneration template; as the first phase, the lesional nail unit was excised and subsequently covered by a dermal regeneration template onto the phalangeal bone surface, allowing development of robust granulation with extracellular matrix and vascular network. Thereafter, the second phase employed a full-thickness skin grafting.Results:All three cases accomplished complete removal of the NUM lesion, and achieved a good cosmetic and functional outcome, maintaining physiological firmness, contour, and less contraction and atrophy of the overlying skin. They did not complain of major post-operative complications.Conclusion:Our two-phase approach using a dermal regeneration material is a satisfactory and straightforward technique, achieving a substantial benefit functionally and cosmetically in the post-operative period. We propose that the additional use of a tissue regeneration material can provide superior results for the reconstruction step of excised NUM.
Anchoring Vignettes in EQ-5D-5L Questionnaire: Validation of a New Instrument
Authors: Azzolina Danila , Minto Clara , Boschetto Stefania , Martinato Matteo , Bauce Barbara , Iliceto Sabino , Gregori Dario 
Published: November 2017

Background:Health Related Quality of Life (HRQoL) is an indicator of patient's physical, psychological and social life. HRQoL is influenced by experience, beliefs, perceptions and expectations, and measures subjective perspective of the patient himself. EQ-5D-5L and SF-12 questionnaires are validated instruments useful to measure HRQoL, increasingly administered in electronic formats.Objective:The main purpose is to evaluate the feasibility of anchoring vignettes for the EQ-5D-5L questionnaire, with the aim to improve intergroup comparability of responses among different subjects. A comparison with SF-12 questionnaire is carried out.Method:This is a cross-sectional study conducted at the ambulatories of cardiology of the University Hospital of Padova, in Italy. Thirty-eight subjects with a diagnosis of cardiovascular disease or at risk of cardiovascular disease were enrolled. A factorial analysis has been performed to assess the convergent validity of EQ-5D-5L questionnaire compared to Sf-12. Moreover, a compound Hierarchical Ordered Probit (Chopit) model has been estimated to evaluate if the questionnaire form affects the subjective evaluation process in order to compare EQ-5D-5L with and without vignettes.Results:Correlation and factor analysis demonstrate that EQ_5D questionnaire is coherent with SF-12 in paper format. Chopit model estimation shows that questionnaire format does not affect the subjective question interpretation. Moreover, in a parametric model including vignettes, education attainment, disease severity, and gender are predictors of HRQoL status.Conclusion:The EQ-5D including vignettes in electronic format seems to be a valid tool to measure HRQoL as compared to EQ-5D without vignettes in paper format and to SF-12 questionnaire.
Major Histocompatibility Complex Allele Persistence in Eurasia and America in the Genus Carduelis (Spinus) During Million Years
Authors: Arnaiz-Villena Antonio , Ruiz-del-Valle Valentín , Muñiz Ester , Palacio-Gruber Jose , Campos Cristina , Gómez-Casado Eduardo , Villa Jose Manuel Martín , Serrano-Vela Ignacio 
Published: November 2017

Introduction:GenusCarduelis(Fringillidaefamily) includes goldfinches, siskins, redpolls, greenfinches and crossbills. Many of the species classified within this genus and other related genera have been grouped by using molecular systematics and the mitochondrial cytochrome b (mt cyt b) gene. According to this, the Eurasian siskin (C. spinus)is the only one extant direct ancestor of several North American finches; North American / South American radiations may have been originated by Eurasian siskin (or extinct relative). In the present work, we aim to perform a study of transpecies and transcontinental analyses of MHC (Major Histocompatibility Complex) Class I alleles in several genusCarduelis/Spinusspecies in order to draw evolutionary conclusions in several wild bird species belonging to the genusCarduelis / Spinus.Materials and Methods:Blood was taken from worldwide wild bird species. Passerine phylogeny was done after analysing mtDNA with Maximun Likelihood and Bayesian dendrograms. Major histocompatibility complex alleles were obtained by standard DNA cloning and sequencing.Results:We found two matches between MHC-I DNA alleles from different South American siskins at DNA level. Also, it was observed that the Eurasian siskin shares a protein with pine siskin and another with three South American siskins. Eight South American siskins species also share the same MHC protein. In addition, studied songbirds MHC class I intron 2 is longer than that ofGallus gallus.Conclusion:We have drawn the following conclusions: 1) We present the first direct evidence that “Minimal Essential MHC” does not exist for birds; one of its main definition characters,i.e.: small intron size does not hold for songbirds. 2) We also report that MHC genes transpecies evolution exist in birds by showing also for the first time that worldwide bird species keep the same MHC protein and DNA alleles. 3) New evidences on MHC alleles conservation from EurasianCarduelis spinus(most ancient) to South American siskins (most recent) during million years support that Eurasian siskin is the parental species for American GenusCarduelis (Spinus)species. It is uncertain whether Eurasian siskin (or extant relative) had initially an Holoartic distribution, including America.
Antidiabetic and Antioxidant Potential of GancidinW from Streptomyces Paradoxus VITALK03
Authors: Ravi Lokesh , Ragunathan Adhithya , Krishnan Kannabiran 
Published: November 2017

Background:The aim of the present study was to analyse the antidiabetic and antioxidant potential of GancidinW (GW) extracted fromStreptomyces paradoxusVITALK03.Materials and Methods:Antidiabetic potential of GW was evaluated by assay of α-amylase and α-glucosidase inhibitory activity; haemoglobin glycosylation and yeast glucose uptake. The antioxidant potential of GW was assessed by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay, 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation decolorization assay and superoxide assay. The inhibition of α-amylase and α-glucosidase by GW was also studied byin Silicomolecular docking analysis.Results:GW (1mg/ml) showed 69.32% of α-amylase and 54.04% of α-glucosidase inhibitory activity. GW (1mg/ml) prevented haemoglobin glycosylation up to 30.92% and the glucose uptake by yeast cells was increased up to 64.38%. The binding interaction GW with α-amylase showed the least free binding energy of -6.09Kcal/mol and -7.53Kcal/mol with α-glucosidase by docking studies. GW also demonstrated moderate antioxidant activity in all the antioxidant assays performed.Conclusion:The results of this study suggests that the antidiabetic and antioxidant potential of GW can be probed further to develop GW as effective antidiabetic agent.
Earthworms Converting Milk Processing Industry Sludge into Biomanure
Authors: Singh Satveer , Bhat Sartaj A. , Singh Jaswinder , Kaur Rajinder , Vig Adarsh P. 
Published: November 2017

Aims and Objectives:The present study was conducted to utilize the Milk Processing Industry Sludge (MPIS) for the purpose of vermicomposting, in two sets of experimentsviz. with earthworms (ME) and without earthworms (MW).Methods and Materials:Twenty young non-clitellatedEisenia fetidawere released in each tray. The various parameters like growth, clitellum development, biomass, cocoon production and hatchlings ofE. fetidawere observed after every 15 days, during 90 days of vermicomposting.Results:The maximum growth and better responses were observed in ME25mixtures of MPIS which was the minimum ratio of the waste to CD. The physico-chemical analysis (pH, EC, TKN, TOC, C/N ratio, TAP, TK, TNa) and heavy metals (Cr, Cu, Mn, Pb) were also done before and after vermicomposting process. There was a significant increase in TKN (23-46%), and TAP (39-47%), and a decrease in pH (6.2-6.8%), EC (24.6-37.2%), TOC (16.8-37.9%), C/N ratio (23.8-97.9%), TK (26.6-40.6%), and TNa (31.3-53%) and heavy metals (Cr 30.9-40.6%, Cu 32.7-44.6%, Mn 23.9-36.3%, and Pb 32.6-42.9%) from initial to final feed mixtures with earthworms.Conclusion:Thus the final vermicompost had excellent physico-chemical properties with all nutrients in plant available forms. The study further strengthens that the vermicomposting is an efficient technique in converting MPIS into nutrient rich biomanure in a short period of timei.e. 90 days.
Genetic testing for Best vitelliform macular dystrophy
Authors: Abeshi Andi , Bruson Alice , Beccari Tommaso , Dundar Munis , Viola Francesco , Colombo Leonardo , Bertelli Matteo 
Published: November 2017

Abstract
We studied the scientific literature and disease guidelines in order to summarize the clinical utility of the genetic test for Best vitelliform macular dystrophy (BVMD). BVMD is mostly inherited in an autosomal dominant manner (autosomal recessive transmission is rare). The overall prevalence is currently unknown. BVMD is caused by mutations in the BEST1 gene. Clinical diagnosis is based on clinical findings, ophthalmological examination, optical coherence tomography, electrooculography and electroretinography. The genetic test is useful for confirming diagnosis, and for differential diagnosis, couple risk assessment and access to clinical trials.
Genetic testing for ocular coloboma
Authors: Abeshi Andi , Marinelli Carla , Beccari Tommaso , Dundar Munis , Colombo Leonardo , Bertelli Matteo 
Published: November 2017

Abstract
We studied the scientific literature and disease guidelines in order to summarize the clinical utility of genetic testing for ocular coloboma (COI). COI is inherited in an autosomal dominant manner associated with variations in the PAX6, ABCB6 and FZD5 genes and in an autosomal recessive manner associated with variations in the SALL2 gene. Overall prevalence is 1 per 100,000 live births. Clinical diagnosis is based on clinical findings, ophthalmogical examination, family history, fundus examination and electroretinography. The genetic test is useful for confirming diagnosis, and for differential diagnosis, couple risk assessment and access to clinical trials.
Genetic testing for enhanced S-cone syndrome
Authors: Abeshi Andi , Marinelli Carla , Beccari Tommaso , Dundar Munis , D’Esposito Fabiana , Bertelli Matteo 
Published: November 2017

Abstract
We studied the scientific literature and disease guidelines in order to summarize the clinical utility of genetic testing for enhanced S-cone syndrome (ESCS). The disease has autosomal recessive inheritance, a prevalence of less than one per million, and is caused by mutations in the NR2E3 gene. Clinical diagnosis is based on clinical findings, ophthalmological examination, electroretinography, color vision testing and optical coherence tomography. The genetic test is useful for confirming diagnosis, and for differential diagnosis, couple risk assessment and access to clinical trials.
Genetic testing for inherited eye misalignment
Authors: Abeshi Andi , Fanelli Francesca , Beccari Tommaso , Dundar Munis , Colombo Leonardo , Bertelli Matteo 
Published: November 2017

Abstract
We studied the scientific literature and disease guidelines in order to summarize the clinical utility of genetic testing for Inherited eye misalignment (IEM). Forms of IEM associated with variations in the SALL4, CHN1, TUBB3 and KIF21A genes have autosomal dominant inheritance, whereas those associated with variations in the ROBO3, PHOX2A, HOXA1 and HOXB1 genes have autosomal recessive inheritance. The prevalence of MS is currently unknown. Diagnosis is based on clinical findings, family history, visual acuity testing and fundus examination. The genetic test is useful for confirming diagnosis, and for differential diagnosis, couple risk assessment and access to clinical trials.
Genetic testing for Mendelian cataract
Authors: Abeshi Andi , Zulian Alessandra , Beccari Tommaso , Dundar Munis , Ziccardi Lucia , Bertelli Matteo 
Published: November 2017

Abstract
We studied the scientific literature and disease guidelines in order to summarize the clinical utility of the genetic test for Mendelian cataract (MC). MC is caused by variations in the AGK, BFSP1, BFSP2, CHMP4B, CRYAA, CRYAB, CRYBA1, CRYBA2, CRYBA4, CRYBB1, CRYBB2, CRYBB3, CRYGC, CRYGD, CRYGS, EPHA2, EYA1, FYCO1, FOXE3, FTL, GALK1, GCNT2, GJA3, GJA8, HSF4, LEMD2, LIM2, LSS, MAF, MIP, NHS, PITX3, PAX6, SIPA1L3, SLC16A12, TDRD7, UNC45B, VIM, VSX, and WFS1 genes. The overall prevalence of congenital forms is 71 per 100 000, whereas there is insufficient data to determine the prevalence of the juvenile and age-related forms. Clinical diagnosis is based on clinical findings, age of onset, family history, ophthalmological examination and slit-lamp examination. The genetic test is useful for confirming diagnosis, and for differential diagnosis, couple risk assessment and access to clinical trials.
Genetic testing for Mendelian glaucoma
Authors: Abeshi Andi , Fanelli Francesca , Beccari Tommaso , Dundar Munis , Ziccardi Lucia , Bertelli Matteo 
Published: November 2017

Abstract
We studied the scientific literature and disease guidelines in order to summarize the clinical utility of genetic testing for Mendelian glaucomas, a large heterogeneous group of inherited disorders, classified according to age of onset as congenital glaucoma, juvenile glaucoma and age-related glaucoma. Variations in the TEK, MYOC, ASB10, NTF4, OPA1, WDR36 and OPTN genes are inherited in an autosomal dominant manner and variations in the CYP1B1 and LTBP2 genes have autosomal recessive inheritance. The prevalence of congenital glaucoma is estimated at 1-9 per 100 000, that of juvenile glaucoma at 1 per 50 000, while there is insufficient data to establish the prevalence of age-related glaucoma. Clinical diagnosis is based on clinical findings, age of onset, family history, ophthalmological examination, intraocular pressure, gonioscopy and fundoscopy. The genetic test is useful for confirming diagnosis, and for differential diagnosis, couple risk assessment and access to clinical trials.
Genetic testing for Stargardt macular dystrophy
Authors: Abeshi Andi , Zulian Alessandra , Beccari Tommaso , Dundar Munis , D’Esposito Fabiana , Bertelli Matteo 
Published: November 2017

Abstract
We studied the scientific literature and disease guidelines in order to summarize the clinical utility of genetic testing for Stargardt macular dystrophy (STGD). STGD is mostly inherited in an autosomal recessive manner and rarely in an autosomal dominant manner, with an overall prevalence of 1-5 per 10 000 live births. It is caused by variations in the ABCA4, CNGB3, ELOVL4, PRPH2 and PROM1 genes. Clinical diagnosis is based on ophthalmological examination, fluorescein angiography, electroretinography, visual field testing, optical coherence tomography and color testing. The genetic test is useful for confirming diagnosis, and for differential diagnosis, couple risk assessment and access to clinical trials.