bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Online Media Framing in the Russia-Ukraine Conflict: Comparison of BBC Indonesia and CNN Indonesia
Authors: Bisri Muhammad Hasan , Febriana Poppy 
Published: October 2024

General Background: The Russia-Ukraine conflict has emerged as a pivotal global issue, significantly reshaping the geopolitical landscape. Specific Background: This study examines how mass media outlets, particularly BBC Indonesia and CNN Indonesia, frame their coverage of the conflict, emphasizing the role of media narratives in public perception. Knowledge Gap: While existing research highlights media influence in conflict reporting, there is limited comparative analysis focusing on Indonesian media and their unique framing techniques. Aims: The research aims to explore the differences in narrative construction and coverage strategies employed by BBC Indonesia and CNN Indonesia regarding the Russia-Ukraine conflict. Results: Through a systematic review of news reports, the findings reveal distinct approaches in the two media outlets, characterized by variations in perspective, source selection, and information presentation styles, despite a shared commitment to accuracy. Novelty: This study contributes new insights into the comparative framing of international conflicts by Indonesian media, underscoring the importance of contextual factors in shaping news narratives. Implications: The results suggest that understanding these framing differences is crucial for evaluating media influence on public opinion and discourse surrounding global conflicts, potentially guiding future research and media literacy initiatives in Indonesia and beyond.
Highlights:

Comparative Analysis: The study fills a gap in research by comparing the framing techniques of two prominent Indonesian media outlets, revealing unique narrative constructions.

Diverse Approaches: Findings indicate that BBC Indonesia and CNN Indonesia utilize different perspectives and source selections, affecting how the conflict is portrayed.

Impact on Public Discourse: Understanding these framing differences is essential for assessing media influence on public opinion regarding international conflicts.

Keywords - Russia-Ukraine conflict, media framing, BBC Indonesia, CNN Indonesia, public perception
Examining the Causes and Consequences of Wrongful Arrests in Law Enforcement
Authors: Yunita Aingga Rahma , Rosnawati Emy 
Published: October 2024

General Background: Wrongful arrests represent a significant issue within the criminal justice system, garnering public attention due to their serious consequences. Specific Background: These errors can stem from various factors, including eyewitness misidentification, insufficient evidence, and systemic pressures on law enforcement. Knowledge Gap: Despite the known implications of wrongful arrests, there remains a lack of comprehensive understanding regarding the psychological and social impacts on victims, as well as effective preventive measures. Aims: This research aims to explore the underlying causes of wrongful arrests, their effects on individuals and society, and to identify actionable steps for mitigation. Results: Utilizing qualitative methods, including in-depth interviews and case studies with victims, law enforcement officials, and legal experts, the study reveals that the primary contributors to wrongful arrests are errors in eyewitness identification and the urgency to close cases. Victims report severe psychological trauma and enduring social stigma alongside material losses. Novelty: The findings highlight the necessity of integrating advanced technology in identification processes and revising existing policies to reduce wrongful arrests. Implications: The research underscores the importance of enhanced training for law enforcement, the ethical use of technology, and the establishment of compensation mechanisms for victims, advocating for systematic reforms to strengthen public trust in the justice system and promote accountability in law enforcement practices.
Highlights:

Causes: Eyewitness errors and inadequate evidence lead to wrongful arrests.
Impact: Victims experience trauma and social stigma from wrongful arrests.
Recommendations: Improve training and use advanced technology for identification.

Keywords: wrongful arrest, eyewitness identification, psychological impact, law enforcement, policy reform
Unveiling Indonesia's Precautionary Principle for Trust in Digital Transactions
Authors: Santosa Shilla Hasmara , Purwaningsih Sri Budi 
Published: October 2024

Abstract: This research explores the compliance of the Sejuta Cita platform with Indonesia's Electronic Information and Transactions Law (ITE Law), specifically focusing on Article 28, which addresses misleading information in electronic transactions. The general background underscores the growing importance of digital platforms in event management, necessitating stringent adherence to legal standards. The specific background highlights the critical role of user verification processes in ensuring accurate information and responsible user behavior. Despite the increasing reliance on these platforms, a knowledge gap remains regarding the effective implementation of the precautionary principle within their operational frameworks. The primary aim of this study is to assess whether Sejuta Cita effectively incorporates the precautionary principle into its user verification processes, employing a normative juridical method with a statute approach that analyzes key legal frameworks, including Law No. 19 of 2016 and Law No. 11 of 2008. The results reveal that the platform’s terms of use mandate compliance with ethical norms and legal regulations, thereby emphasizing responsible decision-making during event registrations. The findings also indicate potential violations related to event content, yet confirm that Sejuta Cita's terms require event creators to adhere to applicable regulations. The novelty of this study lies in its detailed examination of the platform's user verification policies and their alignment with the ITE Law. The implications suggest that adherence to the precautionary principle enhances user trust and mitigates legal risks, contributing to the establishment of safer electronic transaction environments in Indonesia.
Highlights:

Compliance Assessment: Evaluates adherence to ITE Law on misleading information.
User Verification: Analyzes precautionary principle implementation in user processes.
Legal Framework: Assesses electronic agreements' implications for event organizers.

Keywords: Sejuta Cita, ITE Law, user verification, precautionary principle, electronic transactions
Revamping E-Commerce Affiliate Contracts to Address Payment Delays Effectively
Authors: Pitaloka Vernanda Diah , Mediawati Noor Fatimah 
Published: October 2024

Abstract: This study investigates the legal dynamics surrounding electronic contracts between TikTok and its affiliates, particularly focusing on commission payment delays before and after TikTok's sale and purchase agreement with Tokopedia. The general background highlights the growing importance of affiliate marketing in e-commerce and the need for clear contractual obligations. The specific background identifies recurring issues related to late commission payments in TikTok’s affiliate agreements, underscoring a significant gap in the legal framework governing these contracts. The primary aim of this research is to analyze changes to TikTok's affiliate agreement post-transaction with Tokopedia, employing normative research methods with a statutory and conceptual approach. The results indicate that the updated TikTok Shop affiliate agreement offers enhanced legal protection, allowing affiliates to file lawsuits in case of violations, and outlines alternative dispute resolution mechanisms, such as complaints at the Seller Center and customer support. The novelty of this study lies in its comprehensive analysis of the amendments to the affiliate agreement, including stricter payment schedules and improved reporting procedures, addressing previous inconsistencies. The implications suggest that these enhancements contribute to better legal protection for affiliates and foster transparency in payment processes, which is crucial for affiliate trust and the overall efficacy of e-commerce operations in Indonesia.
Highlights:

Legal Dynamics: Explores TikTok's affiliate contracts and commission payment challenges.
Updated Agreement: Highlights improvements post-Tokopedia sale for timely commission payments.
Dispute Resolution: Discusses mechanisms for addressing payment delays and ensuring clarity.

Keywords: TikTok, Tokopedia, affiliate agreements, electronic contracts, commission payments
EVALUATING TRACE FOSSILS, FLUVIAL ARCHITECTURE, AND COLONIZATION PATTERNS IN CHANNEL AND OVERBANK DEPOSITS FROM THE MIOCENE VINCHINA FORMATION, WESTERN ARGENTINA
Authors: VALENCIA GUSTAVO L. , BUATOIS LUIS A. , MÁNGANO M. GABRIELA , FARINA MARTIN E. , KRAPOVICKAS VERÓNICA 
Published: October 2024

Abstract
Trace-fossil distribution within the framework of three-dimensional fluvial architecture has been commonly overlooked. The Miocene Vinchina Formation in western Argentina preserves extensive outcrops of fluvial deposits, including architectural elements of both anastomosing and braided systems identified along the Quebrada de La Troya. Multistorey sandy channels, amalgamated sandy channels, heterolithic multistorey channels, channels with gravel bars, abandoned channels, muddy floodplains, crevasse splays, and crevasse channels have been identified. Of these, only the deposits of three elements were bioturbated, namely crevasse splays, anastomosing abandoned channels, and braided abandoned channels. Vertical simple burrows (Skolithos isp.), large-sized J burrows (Capayanichnus vinchinensis), and simple horizontal burrows (Palaeophycus tubularis) are the most common trace fossils in the Vinchina Formation. Other elements include the horizontal meniscate trace Taenidium barretti and the vertebrate footprints Tacheria troyana, Macrauchenichnus troyana, and Ardeipeda isp. The trace-fossil assemblages identified in the Vinchina Formation collectively illustrate the Scoyenia Ichnofacies. In addition, five ichnofabrics are characterized. The position of the water table, substrate consistency, flow energy, and time between depositional events under arid to semi-arid climate conditions were the main parameters controlling bioturbation. Based on detailed observation of the cross-cutting relationship among ichnotaxa, the ichnofabric distribution and the preservation features of the trace fossils studied, a colonization sequence for each of the subenvironments of the Vinchina Formation is proposed in this study. In addition to integration with conventional facies analysis, articulating ichnologic data and fluvial architecture provides further insights into the application of trace fossils to unravel the sedimentary dynamics of alluvial systems.
THE INFLUENCE OF SEASONALITY ON LIVE-DEAD FIDELITY OF CAENOGASTROPODA FROM THE NORTHERN COAST OF SÃO PAULO STATE, BRAZIL
Authors: LIMEIRA JUNIOR SILVIO CESAR MARQUI , MARTINS HENRIQUE BAZZO , PERROCA JÚLIA FERNANDES , RODRIGUES SABRINA COELHO , GHILARDI RENATO PIRANI 
Published: October 2024

Abstract
Environmental seasonality produces variations in the distribution and structure of biodiversity throughout the year. Understanding how ecological fidelity is affected by these variations allows taphonomists to assess not only the degree of fidelity, but also to identify which seasonal assemblage the fossil record reflects. The present study aims to evaluate the fidelity of gastropod mollusks from a tropical soft substrate environment (Ubatuba Bay, Brazil) collected over a 12-month interval. Samples were collected at four sites within a bathymetric interval of 5–15 m. After the taxonomic assessment, statistical analysis of the live-dead assemblages was conducted. For biodiversity, the total number of shells per sampling site, relative abundance, and species richness, as well as the Shannon index were used. Fidelity was based on the relative percentages of species between the living and dead assemblages and similarity between them was measured by the Sørensen index. Our results show that during stable rainfall/fluvial conditions, the number of dead individuals was low, and fidelity was low while during intense turbidity and subsequent death of gastropods, the abundance of dead individuals increased, and fidelity became high. Only at collection site P4, during intense rainfall/fluvial conditions, the diversity and similarity indices showed significant values. The clockwise circulation of water masses within the bay and the upwelling currents in summer, coupled with the physical-geographical barrier at P4, explain the accumulation of shells at the site, as well as its seasonal behavior. Thus, seasonality exhibited a direct impact on the live-dead fidelity of soft-substrate Caenogastropoda from Ubatuba Bay, Brazil.
Poltergeist-Like 2 (PLL2)-dependent activation of the wound response distinguishes systemin from other immune signaling pathways
Authors: Schaller Andreas , Li Rong , Ahmad Fatima Haj , Fuglsang Anja , Steppuhn Anke , Stintzi Annick 
Published: October 2024

Abstract

Systemin, the first signaling peptide identified in plants, mediates induced resistance against insect herbivores in tomato1. Initially, systemin was perceived as a hormone-like, long-distance messenger that triggers systemic defense responses far from the site of insect attack. It was later found to rather act as a phytocytokine, amplifying the local wound response for the production of downstream signals that activate defense gene expression in distant tissues2. Systemin perception and signaling rely on the systemin receptor SYR13. However, the specifics of SYR1-dependent signaling and how systemin signaling differs from other phytocytokine signaling pathways remain largely unknown. Here, we report that systemin activates the poltergeist-like phosphatase PLL2 in a SYR1-dependent manner. PLL2, in turn, regulates early systemin responses at the plasma membrane, including the rapid inhibition of proton pumps through the dephosphorylation of their regulatory C-termini. PLL2 was found to be essential for downstream defense gene induction, ultimately contributing to insect resistance.
Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis
Authors: Cromer M. , Shah Aadit , Majeti Kiran , Ekman Freja , Selvaraj Sridhar , Sharma Devesh , Sinha Roshani , Soupene Eric , Chati Prathamesh , Luna Sofia , Charlesworth Carsten , McCreary Travis , Lesch Benjamin , Tran Tammy , Chu Simon , Porteus Matthew 
Published: October 2024

Abstract

Blood transfusion plays a vital role in modern medicine. However, availability is contingent on donated blood, and frequent shortages pose a significant healthcare challenge. Ex vivo manufacturing of red blood cells (RBCs) derived from universal donor O-negative pluripotent stem cells emerges as a solution, yet the high cost of recombinant cytokines required for ex vivo erythroid differentiation remains a major barrier. Erythropoietin (EPO) signaling through the EPO receptor is indispensable to RBC development, and EPO is one of the most expensive components in erythroid-promoting media. Here, we used design-build-test cycles to develop highly optimized small molecule-inducible synthetic EPO receptors (synEPORs) which were integrated at a variety of genomic loci using homology-directed repair genome editing. We found that integration of synEPOR at the endogenous EPOR locus in an induced pluripotent stem cell producer line enabled culture with small molecule to yield equivalent erythroid differentiation, transcriptomic changes, and hemoglobin production compared to cells cultured with EPO. Due to the dramatically lower cost of small molecules vs. recombinant cytokines, these efforts eliminate one of the most expensive elements of ex vivo culture media—EPO cytokine. Because dependence on cytokines is a common barrier to ex vivo cell production, these strategies could improve scalable manufacturing of a wide variety of clinically relevant cell types. More broadly, this work showcases how protein engineering and genome engineering may be combined to introduce precisely regulated and tunable behavior into cells, an advancement which will pave the way for increasingly sophisticated synthetic biology applications.
Balancing Present Joy and Future Goals: Insights from Delay of Gratification in Chinese Patients with Hypertension– A Qualitative study
Authors: Liu Yuchen , Feng Danni , Huang Sufang , Wang Quan , Zhang Kexin , Huang Jingjing , Sheng Xiaoxuan , Liu Shiya 
Published: October 2024

Abstract

Background: Hypertension is a high-risk factor for cardiovascular and cerebrovascular diseases, and its management still needs to be improved. This study explains this situation from the perspective of delay of gratification and provides new ideas for hypertension management.
Method: A qualitative study was used. Twenty-five community-based hypertensive patients were recruited via maximum variation sampling and purposive sampling. Semistructured interviews were conducted between June 2023 and August 2023 at a community hospital in central China. The interviews were transcribed verbatim and analyzed thematically, and the Colaizzi seven-step analysis method was used to analyze the information.
Results: The delay of gratification in the daily self-management process of hypertensive patients needs to be improved. A lack of long-term health goals, sensitivity to instant pleasure, and attention bias were the main barriers affecting the delay of gratification in hypertensive patients. Autonomous motivation and altruism are facilitating factors for delayed gratification in hypertensive patients.
Conclusion: Medical staff should pay attention to the problem of low self-management levels in hypertensive patients and take the perspective of delay of gratification as a new perspective for targeted intervention in hypertensive patients. They should actively guide patients regarding emotions, cognition, coping strategies, etc., improve their delay of gratification level, and build a long-term health behavior system to achieve more effective disease management and health promotion.
Glucose-6-phosphate Dehydrogenase (G6PD): the Role in Tumor Progression and Immunotherapy
Authors: Gao Yuting , Wang Xuanlin , Sun Ruixin , Li Jing , Li Yaran , Li Dong , Sun Zujun 
Published: October 2024

Abstract

Background: Numerous studies have shown that glucose-6-phosphate dehydrogenase (G6PD) is a tumor-promoting factor in a variety of malignancies. However, it is not entirely clear the role and the potential molecular mechanism of G6PDH in the pathogenesis or clinical prognosis of different tumors.
Methods: This study first investigated the pan-tumoral expression of G6PD, then G6PD gene expression were studied in cancers, survival prognosis, tumor immunity, immunosuppressive cell infiltration, DNA methylation, gene alteration assay, and response to immunotherapy. We also investigated the function of G6PD in the development and prognosis of various cancers.
Results: Our results suggest that G6PD expression was higher in tumor tissues than in normal tissues and was related to tumor stage, metastasis, and prognosis in most cancers and subtypes of the Cancer Genome Atlas. High G6PD expression is protective in a small number of cancers, including paraganglioma, pheochromocytoma, and ovarian serous cystadenocarcinoma. However, it is a risk factor for the majority of cancers. The prognosis for progression-free survival was better in people with G6PD alterations than in those without them. G6PD and immune cell infiltration were significantly positively correlated in prostate cancer, pancreatic adenocarcinoma, liver cancer, and low-grade glioma of the brain. Additionally, the degree of G6PD methylation was shown to inversely correlate with mRNA expression. The PGD, GCLM, SRXN1, TRIM16L, and TXNRD1 genes all showed significant positive correlation with G6PD expression level. The major genetic alterations were missense mutations in G6PD, and mutations at the R192C/S locus were detected in cutaneous melanoma, uterine cancer, and thyroid carcinoma. In several malignancies, G6PD expression is associated with immunological and chemotherapeutic outcomes.
Conclusions: According to the study, patients who expressed more G6PD generally had better therapeutic outcomes. Our study highlights the role of G6PD in oncogenesis, detection, prognosis, and treatment planning.
The student voice in quality assurance. What factors make for a great GP placement in the eyes of undergraduate medical students?
Authors: Thornton Simon , Thompson Trevor , Gresham Maria , James Alice 
Published: October 2024

Abstract

Background
With general practice becoming an increasingly important part of undergraduate medical education, it is vital to have reliable ways for assessing placement quality. The most prevalent tools for such assessment are the Dundee Ready Education Environment Measure (DREEM) and the Manchester Clinical Placement Index (MCPI). These instruments were not specifically designed for use only in GP contexts and were developed without student involvement at inception. As a result, they may omit quality indicators valued by students on GP placement. This study sought to understand the quality of learning in GP from the student perspective and compare this to what is assessed by DREEM and MCPI. We hope the results of this study will inform the development of placement quality questionnaires inspired by the student voice.
Methods
Purposive sampling was used to recruit 17 undergraduate medical students in academic years 3–5 at the University of Bristol into four focus groups. These ran from May 2023 to April 2024 and were based on a topic guide developed and agreed on by all authors. Theoretical saturation was achieved as no new themes emerged in the final focus group. The focus groups were recorded and transcribed in full. The transcripts underwent systematic coding using NVivo. The codes formed the basis for the thematic analysis.
Results
Four main themes emerged: a sense of belonging, quality of learning, efficiency of learning, and the qualities of the GP teacher. These themes are illustrated by pertinent quotes from the focus groups. Subthemes included being given appropriate clinical autonomy within the placement, timely access to resources, structured clinical activities, and tutor qualities such as enthusiasm and leadership.
Conclusions
This paper offers a new perspective on the quality of GP placements by focusing on the student experience. It identifies themes and subthemes that education teams should assess, beyond what's covered by existing tools like MCPI and DREEM. These include students’ sense of belonging, perceived learning efficiency, and appropriate clinical autonomy. We argue that ignoring these areas neglects key aspects of student needs. We are piloting a new questionnaire incorporating these themes to better identify substandard placements and improve student experiences.