bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Impact of Postoperative Recurrence in Patients With Epidermal Growth Factor Receptor–Positive Non‐Small Cell Lung Cancer
Authors: Morita Meiko , Ono Akira , Sekikawa Motoki , Doshita Kosei , Miura Keita , Kodama Hiroaki , Yabe Michitoshi , Morikawa Noboru , Iida Yuko , Mamesaya Nobuaki , Kobayashi Haruki , Ko Ryo , Wakuda Kazushige , Kenmotsu Hirotsugu , Naito Tateaki , Murakami Haruyasu , Isaka Mitsuhiro , Ohde Yasuhisa , Takahashi Toshiaki 
Published: September 2024

ABSTRACTBackgroundMutations in the epidermal growth factor receptor (EGFR) gene are the most common targetable gene alterations in non‐small cell lung cancer (NSCLC). In Japan, approximately 40% of patients who undergo surgical resection for non‐squamous NSCLC have EGFR mutations. However, no long‐term studies have been conducted including a large number of EGFR‐positive NSCLC patients with postoperative recurrence (PR).MethodsWe conducted a retrospective observational study of the data of EGFR‐positive NSCLC patients with PR who had undergone surgery at the Shizuoka Cancer Center between October 2002 and November 2017. We evaluated post‐recurrence overall survival (PRS) and postoperative overall survival (POS) using the Kaplan–Meier method and identify any associations between the clinical variables at recurrence and PRS using univariate and multivariate analysis.ResultsWe enrolled 162 patients. The median observation time for PRS was 4.95 years (range, 0.82–13.25) and POS was 5.81 years (range, 2.84–16.71). The median PRS was 5.17 years (95% confidence interval [CI], 3.90–5.61) and POS was 7.07 years (95% CI, 5.88–8.01). Univariate analysis identified male sex (median PRS: 3.32 vs. 5.39 years; p < 0.05), bone metastasis (median PRS: 2.43 vs. 5.33 years; p < 0.05), and central nervous system (CNS) metastasis (median PRS: 3.05 vs. 5.39 years; p < 0.05) and multivariate analysis identified bone metastasis (hazard ratio [HR], 2.01; 95% CI, 1.23–3.28; p < 0.05) and CNS metastasis (HR, 1.84; 95% CI, 1.14–2.98; p < 0.05) as poor prognostic factors. The pattern of recurrence (oligo vs. non‐oligo recurrence) was not a prognostic factor. Logistic regression analysis revealed the association between sex and the presence bone/CNS metastasis at recurrence.ConclusionOur data may help visualize future prospects and determine the timing of osimertinib initiation. New treatment strategies need to be developed for patients with bone/CNS metastasis at the first recurrence.
Coordination Chemistry and Reactivity of a Lewis Acidic Di‐Zinc Framework Supported by Bisphenoxymethanone Ligands
Authors: Wu Ding‐Hong , Lin Xin‐Jie , Benchaphanthawee Wachara , Lee Yen‐Hua , Lin Zih‐Chen , Li Han‐Jung , Chen Pei‐Lin , Kuo Ting‐Shen , Wang Chien‐Lung , Wu Yen‐Ku , Peng Chi‐How , Liu Hsueh‐Ju 
Published: September 2024

AbstractWe present the synthesis, structural characterization, and reactivity studies of a tetra‐zinc complex supported by the bisphenoxymethanone ligands and its transformation into various di‐zinc architectures. Our findings highlight the potential of these complexes in molecular recognition, supramolecular chemistry, and catalysis.
Indium‐Iron Oxide Nanosized Solid Solutions as Photocatalysts for the Degradation of Pollutants under Visible Radiation
Authors: Cani Damiano , Cuyvers Timo , Pescarmona Paolo P. 
Published: September 2024

AbstractA series of solid solutions of indium and iron oxides with different In/Fe ratios (InxFeyO3, with x + y = 2) were synthesized in the form of nanoparticles (diameter of ca. 30–40 nm) with the purpose of generating enhanced photocatalysts with an intermediate band gap compared to those of the monometallic oxides, In2O3 and Fe2O3. The materials were prepared by co‐precipitation from an aqueous solution of iron and indium nitrates and extensively characterized with a combination of techniques. XRD analysis proved the formation of the desired InxFeyO3 solid solutions for Fe content in the range 5–25 mol%. UV‐Vis absorption analysis showed that the substitution of In with Fe in the crystalline structure led to the anticipated gradual decrease of the band gap values compared to In2O3. The obtained semiconductors were tested as photocatalysts for the degradation of model organic pollutants (phenol and methylene blue) in water. Among the InxFeyO3 solid solutions, In1.7Fe0.3O3 displayed the highest photocatalytic activity in the degradation of the selected probe molecules under UV and visible radiation. Remarkably, In1.7Fe0.3O3 showed a significantly enhanced activity under visible light compared to monometallic indium oxide and iron oxide, and to the benchmark TiO2 P25. This demonstrates that our strategy consisting in engineering the band gap by tuning the composition of InxFeyO3 solid solutions was successful in improving the photocatalytic performance under visible light. Additionally, In1.7Fe0.3O3 fully retained its photocatalytic activity upon reuse in four consecutive cycles.
A comprehensive 26‐color immunophenotyping panel to study the role of the gut‐liver axis in chronic liver diseases
Authors: Bruneau Alix , Shevchenko Yaroslava , Tacke Frank , Hammerich Linda 
Published: September 2024

AbstractThe gut‐liver axis includes the bidirectional communication between the gut and the liver, and thus covers signals from liver‐to‐gut and from gut‐to‐liver. Disruptions of the gut‐liver axis have been associated with the progression of chronic liver diseases, including alcohol‐related and metabolic dysfunction‐associated steatotic liver disease and cholangiopathies. Immune cells and their expression of pattern recognition receptors, activation markers or immune checkpoints might play an active role in the communication between gut and liver. Here, we present a 26‐color full spectrum flow cytometry panel for human cells to decipher the role of circulating immune cells in gut‐liver communication during the progression of chronic liver diseases in a non‐invasive manner, which has been optimized to be used on patient‐derived whole blood samples, the most abundantly available clinical material. Our panel focuses on changes in pattern recognition receptors, including toll‐like receptors (TLRs) or Dectin‐1, and also includes other immunomodulatory molecules such as bile acid receptors and checkpoint molecules. Moreover, this panel can be utilized to follow the progression of chronic liver diseases and could be used as a tool to evaluate the efficiency of therapeutic targets directed against microbial mediators or modulating immune cell activation.
A compact 6‐shaped high isolation MIMO antenna for 28 GHz 5G applications
Authors: Chowdhury Md. Zikrul Bari , Islam Mohammad Tariqul , Hossain Ismail , Samsuzzaman Md 
Published: September 2024

SummaryThis study presents the design, fabrication, and measurement of a novel MIMO antenna for 28 GHz 5G applications. The design includes two compact antennas with dimensions of 12.8 × 12.8 × 1.6 mm3, placed side by side in a symmetrical arrangement. The antenna being considered operates within the 28 GHz frequency range and has excellent characteristics in terms of reflection coefficient, isolation, and impedance matching. The measurements conducted encompassed both single and MIMO setups and focused on important parameters such the reflection coefficient, transmission coefficient, gain, and efficiency. The MIMO antenna exhibited a reflection coefficient of −62.52 dB at a frequency of 27.93 GHz, while the transmission coefficient was found to be −37.23 dB. The antenna attained a gain of 6.02 dB relative to an isotropic radiator (dBi) and exhibited a maximum efficiency of 90.73%, encompassing a bandwidth of 4.45 MHz (MHz). The simulated envelope correlation coefficient (ECC) was found to be less than 0.003, indicating a very low error rate. Additionally, the antenna attained a diversity gain of 9.998 dB. The suggested MIMO antenna is very suitable for 5G applications operating at 28 GHz.
The mechanism of action and chemical synthesis of FDA newly approved drug molecules
Authors: Shen Dan‐Dan , Zhang Yue‐Lin , Li Xiang , Bai Yi‐Ru , Xiong Jun‐Feng , Seng Dong‐Jie , Zhang Yao‐Dong , Liu Hong‐Min , Yuan Shuo , Yang Li 
Published: September 2024

AbstractIn 2023, the U.S. Food and Drug Administration has approved 29 small molecule drugs. These newly approved small molecule drugs possess the distinct scaffolds, thereby exhibiting diverse mechanisms of action and binding modalities. Moreover, the marketed drugs have always been an important source of new drug development and creative inspiration, thereby fostering analogous endeavors in drug discovery that potentially extend to the diverse clinical indications. Therefore, conducting a comprehensive evaluation of drug approval experience and associated information will facilitate the expedited identification of highly potent drug molecules. In this review, we comprehensively summarized the relevant information regarding the clinical applications, mechanisms of action and chemical synthesis of 29 small molecule drugs, with the aim of providing a promising structural basis and design inspiration for pharmaceutical chemists.
From land to deep sea: A continuum of cumulative human impacts on marine habitats in Atlantic Canada
Authors: Murphy Grace E. P. , Stock Andy , Kelly Noreen E. 
Published: September 2024

AbstractEffective management and mitigation of multiple human impacts on marine ecosystems require accurate knowledge of the spatial patterns of human activities and their overlap with vulnerable habitats. Cumulative impact (CI) mapping combines spatial information and the intensity of human activities with the spatial extent of habitats and their vulnerabilities to those stressors into an intuitive relative CI score that can inform marine spatial planning processes and ecosystem‐based management. Here, we mapped potential CIs of 45 human activities from five sectors (climate change, land‐based, marine‐based, coastal, commercial fishing) on 21 habitats in Atlantic Canada's Scotian Shelf bioregion. We applied an uncertainty and sensitivity analysis to assess the robustness of results and identify hot and cold spots of CIs. Nearly the entire Scotian Shelf bioregion experiences the CIs of human activities, and high CIs were frequently associated with multiple stressors. CIs varied widely across habitats: CI scores in habitats >30 m deep were dominated by climate change and commercial fishing, while nearshore habitats were influenced by a much wider range of activities across all five sectors. When standardized by area, coastal habitats had among the highest CI scores, highlighting the intensity of multiple stressors in these habitats despite their relatively small spatial extent and emphasizing the importance of a multisector approach when managing coastal ecosystems. Robust hot spots of CIs (i.e., areas with high CI scores that were insensitive to alternative modeling assumptions and simulated data quality issues) occurred mostly in coastal areas where multiple high‐intensity activities overlapped with highly vulnerable biogenic habitats. In contrast, robust cold spots of CI mostly occurred offshore. Overall, our results emphasize the need to consider CIs in management and protection and demonstrates that, in many areas, targeting only one activity will be insufficient to reduce overall human impact. The CI map will be useful to highlight areas in need of protection from multiple human impacts, provide information for ecological indicator development, and establish a baseline of the current state of human use in the bioregion.
Bringing population ecology back to wild bees
Authors: Dorian Nicholas N. , McCarthy Max W. , Crone Elizabeth E. 
Published: September 2024

AbstractIn recent years, motivated by widespread declines in wild bees, ecologists have prioritized learning about patterns of wild bee communities across the landscape at the expense of learning about the population‐level mechanisms driving those patterns. In this essay, we seek to revitalize the tradition of studying wild bee populations in a way that both contributes key knowledge for bee conservation and builds a strong conceptual understanding of the processes underpinning bee populations. We address two widespread concerns about investing in population‐level research. First, that population‐level studies are too conceptually narrow to provide broad inference. If population‐level studies are couched in general ecological theory, then findings from a single species can be generalized to many. We highlight how wild bees would make excellent candidates for exploring five areas of general ideas in population ecology, including nutritional ecology, drivers of vital rates, phenology and voltinism, habitat selection, and movement. Second, we address the concern that methods for studying bees at the population level are too difficult to implement. Methods for conducting population‐level studies of bees—specifically, identifying living bees in the field and studying individuals throughout their life cycles—are feasible to implement at the scales appropriate for answering population‐level questions, for example, a few species at a few sites. To facilitate adoption of these ideas, we developed an online field guide (www.watchingbees.com) and a detailed methods manual. More generally, we emphasize the value of linking data‐rich pattern‐oriented approaches in ecology with an understanding of the basic biology and mechanisms that generate those patterns.
Planted species influences soil phosphorus losses in a historically fertilized pasture system: A mesocosm study
Authors: Petticord Daniel F. , Boughton Elizabeth H. , Li Haoyu , Qiu Jiangxiao , Saha Amartya , Zhi Ran , Sparks Jed P. 
Published: September 2024

AbstractThe gradual accumulation of phosphorus from historical fertilization can contribute to the eutrophication of surface waters by increasing the potential for subsurface leaching losses. Grazing lands areas are a priority for concern, and phytoremediation efforts in grazing lands have prioritized grasses that may be used as forage for cattle. This study investigated the influence of three different forage species—Paspalum notatum, Hemarthria altissima, and Cynodon nlemfuensis—on the loss of phosphorus in leachate from surface soils. The experiment used a nested pot mesocosm design that allowed us to monitor leachate volume and concentration biweekly over the course of 3 months. Pots containing P. notatum plants leached significantly more phosphorus than pots containing C. nlemfuensis or empty pots with no plants growing in them, despite losing an equivalent amount of water. H. altissima lost equivalent amounts of phosphorus in leachate water, but each H. altissima plant removed approximately 33.6 mg of phosphorus, approximately 2.5× that removed by P. notatum (13.4 mg). C. nlemfuensis had lower average leachate phosphorus concentrations at each biweekly sampling than either plant species (C. nlemfuensis‐P. notatum, padj = 0.001; C. nlemfuensis‐H. altissima, padj = 0.02), averaging only 0.110 ppm in leachate relative to 0.175 ppm and 0.200 ppm in pots beneath H. altissima and P. notatum, respectively. This, combined with C. nlemfuensis' slightly higher‐than‐average aboveground P content and overall aboveground biomass expression suggest it is the best possible phytoremediation candidate. As even minor leachate P loads can be critically threatening to neighboring oligotrophic water bodies, if the conservation of downstream environments is the priority, the short‐term threat of increased leachate must be considered. Further research is needed to explore the underlying mechanisms and field‐scale implications of these findings.
Minimum habitat size required to detect new rare species
Authors: Chen Youhua , Shen Tsung‐Jen 
Published: September 2024

AbstractConservation of species requires the protection of the associated suitable habitat. However, it is usually not known how much habitat is required to detect a single rare species. This problem is important, and it is related directly to the success and optimization of conservation planning. However, to date, no statistical methods have been developed to address this problem adequately. In this study, from a statistical sampling theory, we propose an estimator to estimate the minimum area required to conserve one or more additional new rare species. The estimator is highly accurate, as demonstrated by numerical tests. Applying the estimator in a tropical forest plot showed that the additional habitat size required for discovering an additional individual of a previously unseen tropical tree species is about 3.86 ha with a SE of 1.10 ha. In conclusion, the proposed estimator may be applied to conservation planning by assisting conservation biologists and policymakers to balance urban‐related and conservation‐related land uses by estimating the minimum detection areas required for species.
Temperature dependence of leaf breakdown in streams differs between organismal groups and leaf species
Authors: Cummins Carolyn S. , Rosemond Amy D. , Tomczyk Nathan J. , Wenger Seth J. , Bumpers Phillip M. , Gulis Vladislav , Helton Ashley M. , Benstead Jonathan P. 
Published: September 2024

AbstractIncreased temperatures are altering rates of organic matter (OM) breakdown in stream ecosystems with implications for carbon (C) cycling in the face of global change. The metabolic theory of ecology (MTE) provides a framework for predicting temperature effects on OM breakdown, but differences in the temperature dependence of breakdown driven by different organismal groups (i.e., microorganisms vs. invertebrate detritivores) and litter species remain unresolved. Over two years, we conducted 12 60‐day leaf litterbag incubations in 20 headwater streams in the southern Appalachian Mountains (USA). We compared temperature dependence (as activation energy, Ea) between microbial and detritivore‐mediated breakdown, and between a highly recalcitrant (Rhododendron maximum) and a relatively labile (Acer rubrum) leaf species. Detritivore‐mediated breakdown had a higher Ea than microbial breakdown for both leaf species (Rhododendron: 1.48 > 0.56 eV; Acer: 0.97 > 0.29 eV), and Rhododendron breakdown had a higher Ea than Acer breakdown for both organismal groups. Similarly, the Ea of total (coarse‐mesh) Rhododendron breakdown was higher than the Ea of total Acer breakdown (0.89 > 0.52 eV). These effects for total breakdown were large, implying that the number of days to 95% mass loss would decline by 40% for Rhododendron and 26% for Acer between 12°C (our mean temperature value) and 16°C (+4°C, reflecting projected increases in global surface temperature due to climate change). Despite patterns in Ea, overall breakdown rates were higher for microbes than detritivores, and for Acer than Rhododendron over most of our temperature gradient. Additionally, the Ea for a subset of the microbial breakdown data declined from 0.40 to 0.22 eV when fungal biomass was included as a model predictor, highlighting the key role of fungi in determining the temperature dependence of litter breakdown. Our results imply that, as streams warm, routing of leaf litter C to detritivore‐mediated fates will increase faster than predicted by previous studies and MTE, especially for labile litter. As temperatures rise, earlier depletion of autumn‐shed, labile leaf litter combined with rapid breakdown rates of recalcitrant litter could exacerbate seasonal resource limitation and alter carbon storage and transport dynamics in temperate headwater stream networks.
The Mayo ATTR‐CM score versus other diagnostic scores and cardiac biomarkers in patients with suspected cardiac amyloidosis
Authors: Bonfioli Giovanni Battista , Tomasoni Daniela , Vergaro Giuseppe , Castiglione Vincenzo , Adamo Marianna , Fabiani Iacopo , Loghin Victor , Lombardi Carlo Mario , Nicolai Alessio , Metra Marco , Emdin Michele , Aimo Alberto 
Published: September 2024

AbstractAimsSeveral scores were developed to help the diagnosis of cardiac amyloidosis (CA). The most recent one, being the Mayo transthyretin amyloidosis cardiomyopathy (ATTR‐CM) score, was not externally validated. We compared the diagnostic performance of the ATTR‐CM score with previous tools (increased wall thickness [IWT] score, AMYLoidosis Index [AMYLI] score, and cardiac biomarkers) in a cohort of patients evaluated for a suspicion of CA.Methods and resultsWe analysed 362 consecutive patients referred to a third‐level centre for suspected CA. Overall, 132 (36%) had transthyretin CA (ATTR‐CA), and 91 (25%) immunoglobulin light chain CA (AL‐CA); CA was excluded in 139 (38%). ATTR‐CM score had a good diagnostic performance to distinguish ATTR‐CA from AL‐CA or no CA, with an area under the curve (AUC) of 0.795 (95% confidence interval [CI] 0.747–0.842, p < 0.001), and ATTR‐CA from no CA (AUC 0.822, 95% CI 0.774–0.871, p < 0.001). Results were consistent in both patients with preserved (AUC 0.787, 95% CI 0.726–0.848, p < 0.001), and reduced or mildly reduced ejection fraction (AUC 0.790, 95% CI 0.709–0.871, p < 0.001). The ATTR‐CM score showed a better discrimination compared to IWT and AMYLI score to distinguish ATTR‐CA from AL‐CA or no CA (p = 0.002), but not to distinguish ATTR‐CA from no CA (p = 0.270). Diagnostic accuracy was significantly higher for the ATTR‐CM score as compared to the rule‐in cut‐off of high‐sensitivity troponin T.ConclusionThe Mayo ATTR‐CM score has a good performance in identifying patients with ATTR‐CA, with also better discrimination power when compared to other scores and biomarkers.
Construction of Aryl Azide‐ and Triazole‐Based Unnatural Amino Acid Motifs via the Pd(II)‐Catalyzed C(sp3)−H Arylation
Authors: Suwasia Sonam , Arulananda Babu Srinivasarao 
Published: September 2024

AbstractThis paper reports a method for the synthesis of examples of aryl azide‐ and triazole moiety‐based unnatural amino acid motifs using the Pd(II)‐catalyzed arylation of the prochiral C(sp3)−H bonds of carboxamides of amino acids as one of the key transformations. Synthesis of racemic and enantioenriched aryl azide‐based unnatural amino acid motifs including, norvaline, leucine, norleucine, phenylalanine, 2‐aminobutyric acid, 2‐aminooctanoic acid, and non‐α‐amino acid derivatives were shown. Additionally, we attempted the synthesis of triazole moiety‐installed norvaline, leucine, norleucine, phenylalanine, 2‐aminobutyric acid, 2‐aminooctanoic acid, and non‐α‐amino acid derivatives via the Cu‐catalyzed Click reaction. We also demonstrated the removal of the protecting groups and the synthesis of free amino group‐containing aryl azide‐ or triazole‐based unnatural amino acid motifs and peptides. Generally, azide moiety‐containing unnatural amino acid motifs are important molecular tools in chemical biology. Furthermore, aryl azide‐ and triazole moiety‐containing unnatural amino acid scaffolds are notable substrates in medicinal chemistry and drug discovery research. Accordingly, this work contributes to enriching the library of aryl azide‐ and triazole‐based unnatural amino acid derivatives.