bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining spatial clustering and tour planning for efficient full area exploration
Authors: Bao Jiatong , Mamun Sultan , Bao Jiawei , Zhang Wenbing , Yang Yuequan , Song Aiguo 
Published: September 2024

AbstractAutonomous exploration in unknown environments has become a critical capability of mobile robots. Many methods often suffer from problems such as exploration goal selection based solely on information gain and inefficient tour optimization. Recent reinforcement learning-based methods do not consider full area coverage and the performance of transferring learned policy to new environments cannot be guaranteed. To address these issues, a dual-stage exploration method has been proposed, which combines spatial clustering of possible exploration goals and Traveling Salesman Problem (TSP) based tour planning on both local and global scales, aiming for efficient full-area exploration in highly convoluted environments. Our method involves two stages: exploration and relocation. During the exploration stage, we introduce to generate local navigation goal candidates straight from clusters of all possible local exploration goals. The local navigation goal is determined through tour planning, utilizing the TSP framework. Moreover, during the relocation stage, we suggest clustering all possible global exploration goals and applying TSP-based tour planning to efficiently direct the robot toward previously detected but yet-to-be-explored areas. The proposed method is validated in various challenging simulated and real-world environments. Experimental results demonstrate its effectiveness and efficiency. Videos and code are available at https://github.com/JiatongBao/exploration.
Christ the King
Authors: Cary-Elwes  
Published: September 2024

We know Christ was to have been a king, because for one thing he was to
sit on the throne of David his father. Pilate, when he said provokingly,
‘Art thou a king then?’ spoke more truly than he was aware. The populace
that haunted Jesus’s footsteps, that followed, followed for the sake of a
miracle, it too was convinced that Jesus was the king who was to come. On
one occasion they went so far as to attempt force in order to have their way
with him; but he fled to the mountains alone.
It was certainly this riotous and revolutionary attitude of the crowd
that made our Lord, not disown the title, but avoid it. Nevertheless on two
great occasions he bore it publicly, and once he suffered it, when mockingly
acknowledged, in silence.
The first occasion was Palm Sunday. Of all the scenes in the New
Testament, that is one of the most strange. Christ had implied he would not
go up to Jerusalem at that time, but he had gone up alone.
'So Let Your Light Shine Before Men'
Authors: Graef H. C. 
Published: September 2024

He who called himself the Light of the World said to those who followed him: ‘So let your light shine before men that they may see your good works and glorify your Father who is in heaven'—and from that day to this the light has been shining in the hearts of men.What exactly is this light that shines in the disciples of our Lord, that, very near our own time, shone with such splendour in the great little saint of Lisieux? Though Jesus calls it your light', it is not a light that is ours by the very fact that we are human beings, as is our memory, our reason or our will; it is something that we have received in a very special way, for it is the divine gift of faith. And this light of faith that is in us our Lord bids us not to hide under a bushel but to let it shine.
Unstable right ventricular hypertension in pulmonary atresia and intact ventricular septum: a case report
Authors: Griesman Joshua D. , Barron David J. , Schwartz Steven M. 
Published: September 2024

AbstractArterial oxygen saturation in single ventricle patients is dependent on systemic cardiac output. Here, we describe a case of a newborn with single ventricle physiology and an unusual mechanism to explain poor cardiac output and cyanosis. This case highlights the importance of identifying and considering ventricular morphology and ventricular-ventricular interactions to understand clinical challenges.
Cardiac effects of COVID-19 infection in children
Authors: Arısüt Berkan , Kavgacı Akif , Gezgin Yıldırım Deniz , Bedir Demirdag Tugba , İncedere Fatma , Canbeyli Fatma , Kula Serdar , Oğuz Deniz , Terlemez Semiha 
Published: September 2024

AbstractBackground:It is known established that the cardiac effects of COVID-19 infection are associated with poor prognosis and high mortality rates in infected patients. The aim of this study was to evaluate the cardiac effects of COVID-19 infection in paediatric patients and identify the correlations between clinical and laboratory data and the degree of cardiac involvement.Materials and Methods:A retrospective data analysis was conducted on 64 paediatric patients at Gazi University Department of Pediatrics who were treated as inpatients with a diagnosis of COVID-19. Patients were classified as “COVID-19-related cardiac involvement cases” if their electrocardiogram and echocardiogram results indicated a pathology and/or if their laboratory data indicated increased cardiac enzymes. All patients were divided into subgroups based on whether they had cardiac involvement and whether they were diagnosed with multisystem inflammatory syndrome in children.Results:In comparison to patients who did not have cardiac involvement, those with cardiac involvement had significantly higher levels of hs-Troponin T, Pro-BNP, and D-dimer. Patients with multisystem inflammatory syndrome in children had significantly longer PR intervals than those without multisystem inflammatory syndrome in children (p = 0.0001). Patients with multisystem inflammatory syndrome in children had a significantly higher rate of pathological valve insufficiencies (68.1%) than those without multisystem inflammatory syndrome in children (14.2%) (p = 0.001).Conclusion:In our study, the strongest predictive biomarker of cardiac involvement in paediatric patients with COVID-19 infection was determined to be hs-Troponin T. It was observed that pathologic electrocardiogram changes could reflect cardiac involvement in the absence of any other signs. Patients with multisystem inflammatory syndrome in children exhibited significantly greater rates of pathologic echocardiogram findings and myocardial dysfunction than those without multisystem inflammatory syndrome in children. In all patients, pathologic electrocardiogram and echocardiogram findings were found to be strongly associated with the severity of inflammation.
Phase angle is inversely related to the consumption of ultra-processed foods and positively related to the consumption of minimally processed foods by university students: a cross-sectional study
Authors: Detopoulou Paraskevi , Levidi Despoina , Magni Olga , Dedes Vassilios , Tzoutzou Milia , Fappa Evaggelia , Gioxari Aristea , Panoutsopoulos Georgios 
Published: September 2024

Abstract

Objective:
Ultra-processed foods (UPF) and minimally processed foods (MPF) consumption are differentially connected to adiposity and possibly body composition. Phase angle (PhA) originates from bioelectrical impedance analysis (BIA) and is connected to cellular health. This study is the first to investigate associations between UPF/MPF consumption and PhA.

Design:
A cross-sectional study was conducted. Anthropometrical and BIA were performed. The Hellenic Physical Activity Questionnaire was used for physical activity evaluation, while a validated FFQ was used for dietary assessment. UPF and MPF intake (% energy) were determined according to the NOVA system. Partial correlation coefficients of PhA and dietary variables were assessed after multi-adjustment.

Participants:
Students were recruited (n 151, 114 women).

Setting:
University

Results:
Median and interquartile range (IQR) of PhA were 5·5° (5·1–6·4°) in the total sample, 6·8° (6·1–7·3°) in men and 5·3° (5·1–5·9°) in women (P < 0·001). The median and IQR for UPF consumption was 13·7 (8·1–33·4) % in the total sample, 23·8 (8·1–70·5) % in men and 12·9 (8·1–27·5) % in women (P < 0·001). The mean (sd) of MPF consumption was 60·2 (sd 15·7) % for the total sample, 59·1 (sd 16·4) % for men and 60·5 (sd 15·6) % for women (P = 0·720). The consumption of UPF was negatively (rho = –0·267, P = 0·002), while the consumption of MPF was positively (rho = 0·218, P = 0·010) associated with the PhA, after adjustment for age, sex, BMI and physical activity.

Conclusion:
PhA relates inversely to UPF and positively to MPF consumption. The observed associations possibly reflect the effects of diet on cellular health and in turn PhA.
Developing, delivering and evaluating a university-led cognitive behavioural therapy service for students
Authors: Robinson Lucy J. , Marshall Ellen , Dodd Alyson , Yeebo Mma , Morrison Rochelle , Lomax Claire 
Published: September 2024

Abstract
Demand for student mental health services is growing, as is the complexity of presentations to university student wellbeing services. There is a need for innovative service delivery models to prevent students falling in the gaps of existing provision, where outcomes from traditional talking therapies services have been shown to be poorer for students than non-student peers. In 2018, Newcastle University established a pilot in-house cognitive behavioural therapy (CBT) service to provide high-intensity CBT for students at the university, harnessing the expertise of qualified and training staff from the psychological professions. This subsequently expanded into the Psychological Therapies Training and Research Clinic, appointing additional clinical staff. Here we present the journey of the clinic, from inception to implementation and expansion. We also present a descriptive evaluation of the first three years of operation, reporting on clinical activity, clinical outcomes and client experiences of the service. Data are presented from 605 referrals. Over 70% of referrals were assessed and over 60% transitioned into treatment. The treatment completion rate was 50%, with an overall recovery rate of 47.3% [using the same definition of recovery as NHS Talking Therapies for Anxiety and Depression (NHS TTAD)]. Satisfaction, measured by the Patient Evaluation Questionnaire, was high. These outcomes are commensurate or better than seen in NHS TTAD services for students and young adults. Overall, the clinic has been a successful addition to the wellbeing offer of the university and has provided a number of positive further opportunities for both research and the clinical training programmes.

Key learning aims

(1)
To understand the process followed to establish a university-run cognitive behavioural therapy service for students and enable other institutions to replicate this model.

(2)
To identify whether universities can deliver safe, effective mental health services that are fully evaluated and result in commensurate clinical outcomes to other service contexts.

(3)
To reflect on key learning, challenges and ethical considerations in establishing such services.
Plasma Sheet Magnetic Flux Transport During Geomagnetic Storms
Authors: Raptis Savvas , Merkin Viacheslav , Ohtani Shinichi , Gkioulidou Matina , Regoli Leonardo H. 
Published: September 2024

AbstractPlasma sheet convection is a key element of storm‐time plasma dynamics in the magnetosphere. While decades of observations have advanced our understanding of convection in general, specifically storm‐time convection remains poorly understood. Using data from ISAS/NASA's Geotail and NASA's MMS, this study characterizes plasma sheet magnetic flux transport across the magnetotail during numerous storms (both recovery and main phases) and contrasts these observations with those from quiet times. Our findings confirm the well‐documented enhancement of the convection electric field during geomagnetic storms. Beyond that, our results reveal a significant dawn‐dusk asymmetry. At dawn, the elevated convection is realized via relatively faster flows while at dusk, through a stronger northward magnetic field. These findings suggest a complex feedback loop between plasma sheet convection and ring current buildup, whereby the latter asymmetrically inflates the magnetotail on the dusk side, shifting the reconnection site and subsequently enhanced earthward flows toward dawn.
Delayed Summer Monsoon Onset in Response to the Cold Tongue in the South China Sea
Authors: Fang Xiaorong , Yu Weidong 
Published: September 2024

AbstractThe interannual variation of the South China Sea (SCS) summer monsoon onset (SMO) may bring extreme weather and climate disasters in East Asia. However, its skillful forecast still remains challenging. This study investigates the intraseasonal ocean‐atmosphere interaction that affects the SCSSMO through diagnostic analysis and numerical experiments. It reveals that the cold sea surface temperature in the Southern SCS during winter (referred as cold tongue, CT) is the key pathway controlling the propagation of the 30–60 days intraseasonal oscillation (ISO) convective system from the Bay of Bengal (BOB) to the SCS. The CT variations affect the interannual variation of the SCSSMO. Specifically, the strong (weak) CT after the peak of La Niña (El Niño) years suppresses (enhances) the propagating ISO from the BOB to the SCS, resulting in a delayed (advanced) SCSSMO. This finding offers the new scientific insights for improving the forecasting of the SCSSMO.
Dynamics of Tidal Effects on Coastal Upwelling Circulation Over Variable Shelves in the Northern South China Sea
Authors: Lin Shangfei , Gan Jianping 
Published: September 2024

AbstractThe impact of tidal forcing on the complex three‐dimensional (3D) wind‐driven upwelling dynamics over highly variable shelves is important but remains unclear. Combining field and satellite observations and a high‐resolution numerical model, we investigated tidal effects on the 3D transport and dynamics of the wind‐driven upwelling circulation in the northern South China Sea. Our results showed that tides weaken (strengthen) the subtidal along‐isobath and cross‐isobath transports in the inner (outer) shelf, primarily by modulating the corresponding cross‐isobath and along‐isobath pressure gradients. The tidally induced geostrophic adjustment is predominantly contributed by its barotropic effect due to sea level gradients above the bottom boundary layer (BBL) in both the inner and outer shelves. The baroclinic process, caused by tidally modulated density gradients, counteracts the barotropic effect and dominates the intensified onshore flow within a thickened BBL from the outer to middle shelves, together with the enhanced bottom stress. Based on the vorticity dynamic, this baroclinic process leads to an amplified joint effect of baroclinicity and relief over the steep shelf that strengthens tidally modulated along‐isobath pressure gradients. While tidally enhanced bottom stress curl can be essential in the inner shelf. The intensity of tidal modulation varies across different shelves, depending on tidal strength and bottom topography. The subtidal bottom onshore transport can increase by sevenfold when strong tidal currents persist over a steep outer shelf. This comprehensive study unveiled the dynamics of tidal effects on the upwelling and the importance of an interlinked tidal‐subtidal system over complex shelf topography.
Real-world outcomes following biochemical recurrence after definitive therapy with a short prostate-specific antigen doubling time: potential role of early secondary treatment
Authors: Freedland Stephen J. , Gao Wei , Lax Angela , Yang Hongbo , Ramaswamy Krishnan , Russell David , Hong Agnes , Ivanova Jasmina I. 
Published: September 2024

Abstract
Background
The natural history of biochemical recurrence (BCR) managed with delayed hormonal therapy is well documented by data from Johns Hopkins. However, as many patients receive treatment prior to metastasis, we evaluated the natural history and role of prostate-specific antigen doubling time (PSADT) in a more contemporary cohort of BCR patients with nonmetastatic castration-sensitive prostate cancer (nmCSPC).

Methods
Patients in the Veterans Health Administration (VHA; 01/01/06 to 06/22/20) with nmCSPC and BCR were divided into rapid ( ≤9 months) and less rapid ( >9 to ≤15 months) PSADT cohorts. Patients with PSADT >15 months were excluded as outcomes, even with delayed treatment, are excellent. Outcomes included time to first antineoplastic therapy after BCR, metastasis, metastasis-free survival (MFS), and overall survival (OS). Cox models adjusted for baseline demographics and clinical characteristics.

Results
Overall, 781 patients with BCR were identified (502 rapid; 279 less rapid PSADT). Rapid PSADT was associated with shorter time to first systemic antineoplastic therapy (median 11.4 vs. 28.3 months, adjusted hazard ratio [95% confidence interval] 2.17 [1.83–2.57]), metastasis (102.4 months vs. not reached, 1.79 [1.33–2.40]), MFS (76.1 vs. 106.3 months, 1.73 [1.33–2.24]), and OS (120.5 vs. 140.5 months, 1.76 [1.22–2.54]) versus less rapid PSADT.

Conclusion
Most patients with rapid PSADT underwent secondary treatment within 1 year after BCR. More contemporary patients treated with early secondary treatment had better outcomes than historical data from patients who had delayed treatment. Whether these results reflect the benefits of early secondary treatment or overall improvements in prostate cancer outcomes over time requires further study.
Self-reported benzodiazepine use among adults with chronic spinal cord injury in the southeastern USA: associations with demographic, injury, and opioid use characteristics
Authors: DiPiro Nicole D. , Dismuke-Greer Clara E. , Krause James S. 
Published: September 2024

Abstract
Study design
Cross-sectional cohort study.

Objectives
To examine: (1) the self-reported frequency of specific prescription benzodiazepine use, (2) concurrent benzodiazepine and opioid use, and (3) sociodemographic, SCI, and opioid use factors associated with frequent benzodiazepine use.

Setting
Community.

Methods
Participants included 918 community dwelling adults with chronic ( > 1 year) traumatic SCI originally identified from a specialty hospital or a state-based surveillance system. Self-reported frequency of specific prescription benzodiazepines and opioids used, concurrent use, and factors associated with use were assessed.

Results
Twenty percent reported any benzodiazepine use in the past year and 13% reported at least weekly use. Concurrent daily or weekly use of benzodiazepines and opioids was reported by 6.5%, with those individuals taking an average of 1.1 (0.4) benzodiazepines and 1.4 (0.6) opioids. Compared to younger adults, those 50–65 years old had lower odds of at least weekly benzodiazepine use (OR = 0.50, 95% CI, 0.29–0.89, p-value = 0.02). Non-Hispanic Blacks reported lower use of benzodiazepines compared to non-Hispanic whites (OR = 0.32, 95% CI, 0.15–0.68, p-value = <0.01). Weekly opioid use was associated with higher odds of using benzodiazepines (OR = 3.10, 95%CI, 1.95–4.95, p-value = <0.01).

Conclusions
Benzodiazepine use was commonly reported among those with SCI. Despite the potential risks, a high portion of those who reported benzodiazepine use also reported prescription opioid use. The findings highlight the need for monitoring of prescription medication use to avoid potentially risky concurrent use and adverse outcomes.
Development of nanocomposite-selenium filter for water disinfection and bioremediation of wastewater from Hg and AgNPs
Authors: Darwesh Osama M. , Matter Ibrahim A. , Abdel-Maksoud Mostafa A. , Al-Qahtani Wahidah H. , El-Tayeb Mohamed A. , Kodous Ahmad S. , Aufy Mohammed 
Published: September 2024

AbstractSelenium nanoparticles (SeNPs) are used in several sectors as antitumor, antimicrobial, and environmental adsorbents. Thus, the present research objective was the production of bacterial-SeNPs as an active and environmentally-friendly antibacterial and adsorbent agents and application into novel nanocomposite filter. From a total of 25 samples (soil, wastewater, and water) obtained from different locations in Egypt, 60 selenium-resistant bacterial isolates were obtained (on a mineral salt medium supplemented with selenium ions). After screening (based on the conversion of selenium from ionic form to nanoform), a superior bacterial isolate for SeNPs formation was obtained and molecular identified as Bacillus pumilus isolate OR431753. The high yield of SeNPs was noted after optimization (glucose as carbon source, pH 9 at 30 °C). The produced SeNPs were characterized as approximately 15 nm-diameter spherical nanoparticles, in addition to the presence of organic substances around these particles like polysaccharides and aromatic amines (protein residues). Also, they have antibacterial activity increased after formation of nanocomposite with nano-chitosan (SeNPs/NCh) against several pathogens. The antibacterial activity (expressed as a diameter of the inhibitory zone) averaged between 2.1 and 4.3, 2.7 and 4.8 cm for SeNPs and SeNPs/NCh, respectively compared with 1.1 to 1.8 cm for Amoxicillin. The produced nanoselenium/chitosan was used as a biofilter to remove mercury (Hg) and AgNPs as model chemicals with serious toxicity and potential pollutant for water bodies in many industries. The new SeNPs/NCh biofilter has proven highly effective in individually removing mercury and AgNPs from their synthetic wastewaters, with an efficiency of up to 99%. Moreover, the removal efficiency of AgNPs stabilized at 99% after treating them with the syringe filter-Se nanocomposite for 4 cycles of treatment (5 min each).
Tumour immune characterisation of primary triple-negative breast cancer using automated image quantification of immunohistochemistry-stained immune cells
Authors: Roostee Suze , Ehinger Daniel , Jönsson Mats , Phung Bengt , Jönsson Göran , Sjödahl Gottfrid , Staaf Johan , Aine Mattias 
Published: September 2024

AbstractThe tumour immune microenvironment (TIME) in breast cancer is acknowledged with an increasing role in treatment response and prognosis. With a growing number of immune markers analysed, digital image analysis may facilitate broader TIME understanding, even in single-plex IHC data. To facilitate analyses of the latter an open-source image analysis pipeline, Tissue microarray MArker Quantification (TMArQ), was developed and applied to single-plex stainings for p53, CD3, CD4, CD8, CD20, CD68, FOXP3, and PD-L1 (SP142 antibody) in a 218-patient triple negative breast cancer (TNBC) cohort with complementary pathology scorings, clinicopathological, whole genome sequencing, and RNA-sequencing data. TMArQ’s cell counts for analysed immune markers were on par with results from alternative methods and consistent with both estimates from human pathology review, different quantifications and classifications derived from RNA-sequencing as well as known prognostic patterns of immune response in TNBC. The digital cell counts demonstrated how immune markers are coexpressed in the TIME when considering TNBC molecular subtypes and DNA repair deficiency, and how combination of immune status with DNA repair deficiency status can improve the prognostic stratification in chemotherapy treated patients. These results underscore the value and potential of integrating TIME and specific tumour intrinsic alterations/phenotypes for the molecular understanding of TNBC.