bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Innovative Method for PDC Bit Design Enhances Stability and Durability Without Deteriorating ROP: Case Studies in Challenging Swamp and Offshore Wells, East Kalimantan, Indonesia
Authors: Hermawan A. , Andoni B. , Wiharja A. , Agriawan C. , Yudhatama M. , Sayogyo B. , Kartaatmadja H. , Nurmida A. , Hendarno B. , Dwikara A. , Sutan M. A. , Huway K. D. , Aribowo T. H. 
Published: October 2024

Abstract
In East Kalimantan offshore drilling operations, Polycrystalline Diamond Compact (PDC) drill bits featuring six-bladed, 16-mm cutters have been predominately used in an 8½-in. hole section. However, a standard S-type well for an 8½-in. hole section in the Handil Field with long interval drilling and deep vertical depth out presents a challenge of high stick/slip vibration. Meanwhile, in the Jempang Field, drilling through various formations consisting of sandstone, claystone, thick limestone, and hard shale using motor assembly could result in bit damage and slow rate of penetration (ROP).
The operator and bit service company used a new approach in the bit selection process to seek a new PDC design and technology that enables drilling in a single run to target depth (TD) with improved durability and stability while achieving high penetration rates. A PDC with seven-bladed 16-mm cutters with the latest cutter-shaped technology was proposed to improve bit durability and drill the entire section in one run at a higher ROP. A new bit design software, coupled with the recommendation for an optimal PDC cutter distribution structure, ensures the bit will improve stability.
The result shows a new design with seven-bladed, 16-mm cutters achieved one run to TD and set the fastest ROP compared to previous cases with six-bladed, 16-mm cutters in both the Handil Field and the Jempang Field. The bit also came out of the well in excellent condition or much better dull condition. In addition, with the combination of this new approach in PDC design and optimal parameters, the stick/slip issue could also be minimized in this first trial in the Handil Field.
This new approach of using a new seven-bladed PDC design with 16-mm cutters that incorporate superior PDC cutter technology and shape has delivered a step change in bit selection to achieve improved durability without compromising on ROP for challenging offshore drilling operations.
Time-Lapse Electromagnetic Corrosion Logging for Predictive Analysis of Pipe Corrosion Rates
Authors: Zulkefli Siti Nor Dahliawati , Zabidi Nur Aina Atikah Mohd Jamel , Baweh Ahmad Azhan Imam , Md Fauzi Ashraf Hidayat , Khonif Hasrul Afendi Ahmad , Anuar Khairina Khairul 
Published: October 2024

Abstract
Operating wells are often exposed to pipes wall corrosion over their operational lifespan. Thus, this highlights the critical need for systematic monitoring and effective management for corrosion. Time-lapse corrosion logging is employed using electromagnetic pulses to assess corrosion rates and predict potential failures in pipes integrity. Utilizing electromagnetic concepts, the goal is to monitor the progress of corrosion and conduct a comparative analysis to determine the percentage of pipe corrosion over an extended timeframe. The process involves a year-long time-lapse corrosion logging initiative, analyzing pipes wall thickness, and conducting comparative assessments to monitor corrosion rates. It includes measuring changes in electromagnetic properties, unveiling potential metal losses across logging intervals. The implementation of magnetic corrosion detection logging assesses average circular metal loss, with the maximum metal loss serving as a standard for corrosion classification. The process estimates wall thickness within the fracture over time, especially during the operational lifespan of the wells.
In the thorough evaluation conducted through time-lapse corrosion logging, the study observed that the percentage of wall losses of the water injector wells throughout logging interval increased. The casing exposure to corrosion can progressively reduce wall thickness over time, revealed by the damage profiles across the analyzed interval. This in-depth observation enhances understanding of dynamic corrosion progression, contributing to a detailed evaluation of the pipe's structural integrity. The significance of these observations lies in predicting potential well integrity failures, especially for wells with tubing-casing communication issues. Actively measuring the remaining thickness of the casing helps establish pressure limits, making it easier to manage the structural integrity effectively and ensure sustained wells performance.
The time-lapse corrosion logging approach provides a dynamic, real-time understanding of corrosion progression within pipes. Unlike static assessments, this method captures evolving corrosion patterns, enhancing predictive capabilities for well integrity. This time-lapse data enables effective structural integrity management, optimized maintenance strategies, and timely mitigation of potential failures, elevating overall system reliability and performance.
Widespread environment-specific causal effects detected in the UK Biobank
Authors: Knusel Leona , Man Alice , Paré Guillaume , Kutalik Zoltán 
Published: October 2024

Abstract

Background: Mendelian Randomization (MR) is a widely used tool to infer causal relationships. Yet, little research has been conducted on the elucidation of environment specific causal effects, despite mounting evidence for the relevance of causal effect modifying environmental variables.
Methods: To investigate potential modifications of causal effects, we extended two-stage-least-squares MR to investigate interaction effects (2SLS-I). We first tested 2SLS-I in a wide range of realistic simulation settings including quadratic and environment-dependent causal effects. Next, we applied 2SLS-I to investigate how environmental variables such as age, socioeconomic deprivation, and smoking modulate causal effects between a range of epidemiologically relevant exposure (such as systolic blood pressure, education, and body fat percentage) - outcome (e.g. forced expiratory volume (FEV1), CRP, and LDL cholesterol) pairs (in up to 337’392 individuals of the UK biobank).
Results: In simulations, 2SLS-I yielded unbiased interaction estimates, even in presence of non-linear causal effects. Applied to real data, 2SLS-I allowed for the detection of 182 interactions (P<0.001), with age, socioeconomic deprivation, and smoking being identified as important modifiers of many clinically relevant causal effects. For example, the positive causal effect of Triglycerides on systolic blood pressure was significantly attenuated in the elderly whilst the positive causal effect of Gamma-glutamyl transferase on CRP was intensified in smokers.
Conclusion: We present 2SLS-I, a method to simultaneously investigate environment-specific and non-linear causal effects. Our results highlight the importance of environmental variables in modifying well-established causal effects.
Upregulated FSP1 by GPD1/1L Mediated Lipid Droplet Accumulation Enhances Ferroptosis Resistance and Peritoneal Metastasis in Gastric Cancer
Authors: Li Shuai , Lin Guoliang , Liu Qingnan , Xie Chengjie , Ding Ke , Mo Guanghua , Zeng Lu , Zhang Fan , Liu RuiXuan , Lu Lei , Hong Wei , Mao Yuling , Su Haibo 
Published: October 2024

Abstract

To successfully metastasize, cancer cells must evade detachment induced cell death, known as anoikis. Unraveling the mechanisms that gastric cancer (GC) circumvent anoikis and achieve peritoneal metastasis especially during unanchored growth, could significantly improve patient outcomes. Our study reveals that GC cells exhibit increased lipid peroxidation, MDA production, and cell death during suspension culture, which can be mitigated by the intervention with liproxstatin-1 and ferrostatin-1. We discovered that oleic acid (OA) or adipocytes stimulate lipid accumulation in GC cells, thereby inhibiting lipid peroxidation and cell death. Lipid mass spectrometry confirmed an upregulation of triglyceride synthesis, indicating that the accumulation of lipid droplet may confer resistance to ferroptosis during suspension growth. In vitro assays demonstrated that OA not only induces lipid droplet accumulation but also upregulates the expression of ferroptosis suppressor protein 1 (FSP1), a process that can be abrogated by the double knockout of GPD1/1L genes. Additionally, we have demonstrated that a decrease in the ubiquitination of FSP1 in GC cells upon lipid droplet accumulation, as well as silencing or pharmacological targeting FSP1, promotes ferroptosis and disrupts the peritoneal metastatic potential of GC cells. Collectively, our findings highlight the potential of FSP1 as a promising therapeutic target for metastatic gastric cancer.
Clinicopathological factors that predict different responses of breast and axillary tumors to neoadjuvant chemotherapy and prognosis among patients with node-positive breast cancer: real world data
Authors: Ji Danyang , Lan Bo , Wang Jiayu , Ma Fei , Luo Yang , Li Qing , Zhang Pin , Cai Ruigang , Li Qiao , Chen Shanshan , Xu Binghe , Fan Ying 
Published: October 2024

Abstract

Background:
Pathological complete response (pCR) has been proven to be related to prognosis. pCR can be further classified as pCR of the breast (bpCR), pCR of axillary lymph nodes (apCR) or pCR of both tumors. The aim of this study was to elucidate the outcomes and clinicopathological characteristics associated with different patterns of pCR.
Methods:
Patients with node-positive disease who received neoadjuvant chemotherapy between August 2009 and July 2016 and who achieved pCR in axillary lymph nodes, breast or both were included. Multivariate logistic regression was used to identify factors related to different patterns of pCR.
Results:
Among the 271 patients who were included in the study, 42.1% achieved total pCR, 46.1% achieved ApCR, and 11.8% achieved BpCR. Disease-free survival (DFS) was significantly better in the total pCR group than in the limited pCR groups throughout the entire cohort (p=0.042). Univariate and multivariate analyses indicated that patients with HR-negative disease and a high Ki-67 proliferation index were more likely to achieve total pCR. Patients with earlier T stage disease were more likely to achieve pCR only in the breast. Among patients who achieved limited pCR, there was no significant difference in terms of whether these patients received intensified adjuvant chemotherapy.
Conclusions:
Total pCR is still the best marker for predicting survival benefit in patients receiving neoadjuvant chemotherapy, and total pCR is more likely to be achieved in patients with HR-negative disease and a high Ki-67 proliferation index. T stage and N stage may predict apCR and bpCR, respectively.
Human breast milk-derived exosomes attenuate lipopolysaccharide-induced upregulation of CD40 and NLRP3 in microglia
Authors: Akinduro Oluwatomi , Kumar Sanjay , Chen Yuechuan , Thomas Barbara , Hassan Quamarul , Sims Brian 
Published: October 2024

Abstract

Microglia mediate the immune response in the central nervous system to many insults, including lipopolysaccharide (LPS), a bacterial endotoxin that initiates neuroinflammation in the neonatal population, especially preterm infants. The synthesis of the proinflammatory proteins CD40 and NLRP3 depends on the canonical ΝF-κΒ cascade as the genes encoding CD40 and NLRP3 are transcribed by the phosphorylated ΝF-κΒ p50/p65 heterodimer in LPS-induced microglia. Exosomes, which are nanosized vesicles (40–150 nm) involved in intercellular communication, are implicated in many pathophysiological processes. Human breast milk, which is rich in exosomes, plays a vital role in neonatal immune system maturation and adaptation. Activated microglia may cause brain-associated injuries or disorders; therefore, we hypothesize that human breast milk-derived exosomes (HBME) attenuate LPS-induced activation of CD40 and NLRP3 by decreasing p38 MAPK and ΝF-κΒ p50/p65 activation/phosphorylation downstream of TLR4 in murine microglia (BV2). We isolated purified HBME and characterized them using nanoparticle tracking analysis, transmission electron microscopy, fluorescence-activated cell sorting, and western blots. Analysis of BV2 microglia exposed to LPS and HBME indicated that HBME modulated the expression of signaling molecules in the canonical ΝF-κΒ pathway, including MyD88, ΙκΒα, p38 MAPK, NF-κB p65, and their products CD40, NLRP3, and cytokines IL-1β and IL-10. Thus, HBME have great potential for attenuating CD40 and the NLPR3 inflammasome signaling in the microglial response to LPS.
Accurate preoperative planning for abdominal aortic aneurysm using fully automated measurement software: A randomized controlled trial
Authors: Guo Linlin , Qi Xiaoyu , Yang Ming , Cai Fei , Zhou Peng , Chen Gezheng , Wu Wanying , Zhu Bingjie , Li Qin , Li Yiqing , Yang Chao 
Published: October 2024

Abstract

Sizing, the first step of endovascular aneurysm repair (EVAR), is essential for a successful procedure. This study evaluated the precision and reproducibility of EVAR sizing facilitated by a novel fully automated software, DetecMicro, in comparison to conventional manual and semi-automatic software. A total of 18 surgeons, consisting of 9 junior residents and 9 vascular surgery specialists, participated in a prospective single-center randomized controlled trial with three parallel arms, stratified based on clinical experience. Each surgeon conducted three repeated measurements for 450 parameters (360 diameter and 90 length parameters). Intra- and inter-observer variability were analyzed using the intraclass correlation coefficient (ICC). Subsequently, the stent size based on the measured results was assessed to determine the impact of measurement errors on stent selection. The reliability of virtual stent implantation (VSI) using DetecMicro was evaluated by comparing it with postoperative models. Compared to PACS and 3mensio, the DetecMicro group exhibited superior accuracy, with 90.39% of diameter measurements and 97.60% of length measurements falling within clinically acceptable ranges, [-2 mm, + 2 mm] and [-5 mm, + 5 mm], respectively. Intra-observer and inter-observer repeatability with DetecMicro demonstrated efficacy, with a mean ICC exceeding 0.9. In the DetecMicro group, clinical experience had a negligible impact on the aforementioned results. VSI, when compared with actual postoperative models, limited errors to within 2 mm. The integration of DetecMicro's measurement and VSI functions holds promise as a reliable tool for preoperative planning in EVAR treatment.
The effects of diagnosis-intervention packet payment on healthcare in Chinese public hospitals: a systematic review and meta-analysis
Authors: Xu Tong , Li Chaofan , Wang Xiaoyong , Jia Liying 
Published: October 2024

Abstract

To control the rapid growth of health expenditures, China developed an innovative case-based payment system for inpatient care called the diagnosis-intervention packet (DIP) payment. However, the effectiveness of DIP payment in public hospitals is mixed. This study aims to conduct a systematic review and meta-analysis to investigate the effects of DIP-based payment on healthcare in terms of quantity, efficiency, quality, and expenditure of public hospitals in China. We searched PubMed, Embase, the Cochrane Library, Web of Science, EBSCO, ProQuest, Opengrey, the China National Knowledge Infrastructure, Wanfang, cqvip, and China Biology Medicine disc from October 2003 to December 2023. Twenty studies were identified and examined, including six non-randomized controlled trials, ten controlled before-after studies, and four interrupted time series studies. The meta-analysis revealed that DIP payment was effective in improving efficiency by shortening the length of stay. There was no significant overall effect on the quantity of healthcare. Based on the results of in-hospital mortality and readmission within 30 days, quality was partially improved. The meta-analysis did not show a significant decrease in total expenditures per case, but there were some positive changes in the structure of hospitalization expenditures. There is insufficient evidence to establish a definitive relationship between DIP-based payment and healthcare in Chinese public hospitals. Future research should explore the long-term effects of the DIP payment reform. Before applying and implementing the DIP-based payment, policymakers need to consider its positive and negative outcomes. This can help policymakers make better decisions on provider payment reform to improve hospital healthcare.
Serv-India Instrument for Measuring Service Quality in Healthcare: Development and Pilot Testing
Authors: Sonali Seep , Shenoy Shweta 
Published: October 2024

Abstract

Aim: The aim of the present study was to develop a viable instrument for measuring service quality (SQ) in the healthcare sector, including a new pool of factors identified that largely influence service quality primarily in the Indian healthcare sector (SERV-INDIA questionnaire).
Methods: An item pool was created by utilizing the SERVQUAL questionnaire as a generic model given by Parasuraman et al. (9) and an expert panel evaluated the items to assess the content validity index and ratio. The reliability, including internal consistency and reproducibility, was examined via Cronbach’s alpha coefficient and the intraclass correlation coefficient (ICC). In addition, a known-group comparison was performed to evaluate how well the questionnaire discriminates the service quality satisfaction index between patients’ expectations and patients’ perceptions and among individuals who are receiving treatment under cash and insurance both public and private during present hospitalization.
Results: A total of one hundred and three participants were studied for pilot testing. The mean age group of the participants was 30-40 years; almost 50% had studied until high school in the context of formal education. Overall, 7% of the participants were low, 19% were marginal, and 70% had an adequate service quality satisfaction index. The internal consistency, as measured by Cronbach’s alpha, was found to be 0.955 for Part-1 and 0.959 for Part-II of the questionnaire. Participants who took treatment under cash during hospitalization had significantly higher satisfaction scores (P <0.001) than patients with insurance both public and private. The association between service quality satisfaction scores and Sifarish was also significant (P < 0.001).
Conclusion: SERV-INDIA is a valid and reliable measure of service quality in the healthcare sector, with newly introduced significant indicators like Mode of payment including Baksheesh and Sifarish.
Signal Mining and Analysis of Adverse Events in Children Using Growth Hormones: A Real-World Study Based on FAERS
Authors: Xu Wan , Bao Jian-an , Fei Yao 
Published: October 2024

Abstract

Objective:This study aims to analyze the adverse event (ADE)related to the use of growth hormone drugs in children through mining the FDA Adverse Event Reporting System (FAERS) database, and provide references for clinical medication safety.
Methods: Data on children under 18 years of agefrom the FAERS database, covering the first quarter of 2004 to the first quarter of 2024, were extracted via the OpenVigil 2.1 tool. The reporting odds ratio (ROR) was employed to analyze adverse event signals related to growth hormones.
Results: A total of 10,487 ADE reports for children using growth hormones were obtained, revealing 381 risk signals across 20 organ systems. The top five system organ categories on the basis of the number of reports were general disorders and administration site conditions (29.82%), investigations (20.11%), musculoskeletal and connective tissue disorders (13.51%), nervous system disorders (13.15%), and neoplasms benign, malignant and unspecified (6.47%). Among the positive signals not mentioned in the product labeling, the top five included non-high-density lipoprotein cholesterol increased, blood 25-hydroxycholecalciferol decreased, blood urea nitrogen/creatinine ratio increased, globulins decreased, elbow deformity.
Conclusion: The signal intensity associated with muscle, skeletal, and neurological abnormalities, as well as tumor occurrence in children via growth hormones, is relatively high. Continuous monitoring and enhanced medication oversight are necessary.
Epidemiology and spatiotemporal analysis of acute hemorrhagic conjunctivitis in Zhejiang province, China, during 2004-2023
Authors: Sun Wanwan , Chen Yijuan , Li Fudong , Qin Shuwen , Miao Ziping 
Published: October 2024

Abstract

Background
Acute hemorrhagic conjunctivitis (AHC) has become a significant public health issue in Zhejiang province. However, the analysis of epidemiological characteristics and spatio-temporal aggregation of AHC in Zhejiang province has not been studied yet.
Methods
Information on sporadic cases and clustered epidemics data of AHC from 2004–2023 in Zhejiang province were obtained from the China Information System for Disease Control and Prevention. Global spatial autocorrelation and local spatial autocorrelation analyses were performed using ArcGIS 10.4 software and GeoDa 1.22 software, spatiotemporal hotspot area detection was carried out using SaTScan 10.1.3 software.
Results
Between 2004 and 2023, 52119 AHC cases were reported in Zhejiang province, resulting in an average incidence of 5.37 per 100000. No death cases occurred. The average age of all cases id 25.44 ± 4.37 years old, 16.70% individuals aged between 10–19 years old, August to October was the peak months in each year; students, farmers and kindergarten children were high incidence people. Positive spatial correlation of AHC in Zhejiang province were observed (Moran’I value between 0.075–0.173, P < 0.001), indicating spatial aggregation, mainly in southwest, central-western and eastern coasts counties in Zhejiang province. Spatiotemporal scanning detected one clusterⅠand one cluster Ⅱaggregation areas, with the clusterⅠaggregation area (RR = 212.44, LRR = 53739.20, P < 0.001) locating in northwestern Zhejiang province, comprising 30 counties, and an aggregation time from 1 September 2010 to 30 September 2010. Epidemiological analysis of 3 outbreaks caused by AHC found that the symptoms of the affected students were mainly conjunctival congestion, increased eye secretions, eye swelling, eye pain, photophobia and tearing, and the proportion of fever was relatively low.
Conclusions
Spatial and temporal aggregation of AHC is evident in Zhejiang province, with the incidence rate increased during August to October. It is important to take prevention and control measures such as monitoring, training and health educating in key population in high-incidence epidemic areas.