bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: ADDITION PRODUCTS OF BENZIMIDAZOLE‐2(2H)‐THIONE AND ACETYLENEDICARBOXYLIC ESTERS
Authors: NAGARAJAN K. , NAIR M. D. , DESAI J. A. 
Published: April 2016

AbstractBenzimidazol‐2‐thion (I) wird mit Acetylendicarbonsäureester (II) in hohen Ausbeuten zu (III) und (IV) umgesetzt.
ChemInform Abstract: HETEROCYCLIC SEVEN‐MEMBERED RING COMPOUNDS. XXII. SYNTHESIS AND THERMOLYSIS OF SUBSTITUTED 4‐PHENYL‐1‐BENZOTHIEPIN 1‐OXIDES
Authors: HOFMANN H. , GAUBE H. 
Published: April 2016

AbstractOxidation des Benzothiepinons (I) mit stöchiometrischen Mengen m‐Chlorperbenzoesäure (MCPB) liefert das Sulfoxid (II), das zu (IIIa) acetyliert wird.
ChemInform Abstract: IV. SILYLATION STUDIES OF 3‐BUTYNOIC ACID AND 2,3‐BUTADIENOIC ACID
Authors: SHEN C. C. , AINSWORTH C. 
Published: April 2016

Abstract3‐Butin‐carbonsäure (I) wird mit LDA und Trimethylchlorsilan zu (II) silyliert, das zu (III) umlagert.
ChemInform Abstract: 4‐DIMETHYLAMINOPYRIDINE: AN EFFICIENT AND SELECTIVE CATALYST FOR THE SILYLATION OF ALCOHOLS
Authors: CHAUDHARY S. K. , HERNANDEZ O. 
Published: April 2016

Abstract4‐Dimethylamino‐pyridin (I) kann als Silylierungsmittel eingesetzt werden, indem die mit entsprechenden Chlorsilanen erhaltenen Salze (II) als Zwischenstufen auftreten.
ChemInform Abstract: A METHOD OF PREPARATION OF URANIUM(+3) COMPOUNDS FROM SOLUTIONS
Authors: DROZDZYNSKI J. 
Published: April 2016

AbstractDie U(III)‐ Verbindungen (I)‐(IV) werden durch die Reduktion von U(IV)‐chlorid mit Znamalgam in Formaldehyd, bei anschließender Reaktion mit Na3PO4 oder in Acetonitril/Propionsäure in Gegenwart entsprechender Mengen K‐, Rb‐, Ammonium‐, Tetraphenylarsonium oder ‐phosphoniumchlorid synthetisiert.
ChemInform Abstract: RHENIUM FORMYL AND CARBOXY COMPLEXES DERIVED FROM THE CYCLOPENTADIENYL(DICARBONYL)NITROSYLRHENIUM(1+) CATION: MODELS FOR THE FISCHER‐TROPSCH AND WATER GAS SHIFT REACTIONS
Authors: CASEY C. P. , ANDREWS M. A. , RINZ J. E. 
Published: April 2016

AbstractBei der Behandlung des kationischen Dicarbonyl‐Re‐Komplexes (I) mit K‐hydridotriisopro‐ poxyborat entsteht der isolierbare, luftempfindliche, neutrale Formyl‐Komplex (II).
ChemInform Abstract: A STUDY OF THE STEREOCHEMISTRY AT IRON OF ELECTROPHILIC CLEAVAGE OF THE IRON‐CARBON Σ BOND IN METHYL(η5‐1‐METHYL‐3‐PHENYLCYCLOPENTADIENYL)CARBONYL(TRIPHENYLPHOSPHINE)IRO# N(II)
Authors: ATTIG T. G. , TELLER R. G. , WU S.‐M. , BAU R. , WOJCICKI A. 
Published: April 2016

AbstractMittels 1H‐NMR‐Spektroskopie und Röntgenkristallographie wird die Stereochemie von Eisen bei der elektrophilen Spaltung der Eisen‐Methyl‐σ‐Bindung, mit Einlagerung oder Eliminierung, in den Diastereomeren der pseudotetraedrischen Titelverbindung (Ia) untersucht.
ChemInform Abstract: 1‐ARSA‐ AND 1,1′‐DIARSAFERROCENES
Authors: THIOLLET G. , MATHEY F. , POILBLANC R. 
Published: April 2016

AbstractDas aus dem Arsol (I) durch Behandlung mit K gebildete 2,5‐Dimethoxyarsolyl‐K reagiert in situ mit Cyclopentadienyldicarbonyl‐ Fe‐Iodid zu dem o‐Arsolyl‐Fe‐Komplex (II).
ChemInform Abstract: AN ADDUCT OF TRANS‐DIIODOBIS(1,2‐DIMETHOXYETHANE)NICKEL(II) AND 1,2‐DIIODOTETRAFLUOROBENZENE
Authors: GOWLING E. W. , MALLINSON R. F. N. , PROCTOR C. J. , SHUTTLEWORTH D. M. 
Published: April 2016

AbstractEine systematische Untersuchung der elementaren Zusammensetzung des Reaktionsgemisches, das sich aus Ni(CO)4, 1,2‐Diiodtetrafluorbenzol und 1,2‐Dimethoxyethan als Lösungsmittel bei 120°C bei Verwendung verschiedener molarer Verhältnisse ergibt, zeigt, daß bei niedriger Konzentration, wenn das Verhältnis von Halogenbenzol zu der Ni‐Verbindung mehr als drei beträgt, die kristalline Titelverbindung entsteht.
ChemInform Abstract: PLANTS WHICH ACCUMULATE METALS. PART IV. A POSSIBLE COPPER‐PROLINE COMPLEX FROM THE ROOTS OF ARMERIA MARITIMA
Authors: FARAGO M. E. , MULLEN W. A. 
Published: April 2016

AbstractPapierchromatographische Untersuchungen des Wasserextrakts aus dem Wurzelgewebe von Armeria maritima bestätigen die Existenz eines Cu‐Prolin‐Komplexes in den Wurzeln.
ChemInform Abstract: EFFICIENT INTRAMOLECULAR QUENCHING AND ELECTRON TRANSFER IN TETRAPHENYLPORPHYRIN ATTACHED WITH BENZOQUINONE OR HYDROQUINONE AS A PHOTOSYSTEM MODEL
Authors: TABUSHI I. , KOGA N. , YANAGITA M. 
Published: April 2016

AbstractDurch Kondensation von o‐Nitrobenzaldehyd (I)‐1nit Benzaldehyd (II) und Pyrrol (III) erhält man in bekannter Weise ein o‐Nitro‐tetraphenyl‐porphyrin (IVa), das zu (IVb) reduziert und dann mit dem Säurechlorid (V) zu (VIa) kondensiert wird.
ChemInform Abstract: STUDIES ON THE TOTAL SYNTHESIS OF RIFAMYCIN. HIGHLY STEREOSELECTIVE SYNTHESIS OF INTERMEDIATES FOR CONSTRUCTION OF THE C(15) TO C(29) CHAIN
Authors: COREY E. J. , HASE T. 
Published: April 2016

Abstracttrans‐3‐Pentensäure (Ia) wird über das mit LDA erhaltene Anion zu (Ib) methyliert und dann der Halolactonisierung zu (IIa) bzw. (IIb) unterworfen.
ChemInform Abstract: STEREOSPECIFIC SYNTHESIS OF (.+‐.)‐TRISPOROL B, A PROHORMONE OF BLAKESLEA TRISPORA, AND A FACILE SYNTHESIS OF (.+‐.)‐TRISPORIC ACIDS
Authors: PRISBYLLA M. P. , TAKABE K. , WHITE J. D. 
Published: April 2016

AbstractDie Darstellung von (i)‐Trisporol B (XI) aus dem Aldehyd (I) und der Tetronsäure (V) wird beschrieben.
ChemInform Abstract: (CIS‐6‐METHYLTETRAHYDROPYRAN‐2‐YL)ACETIC ACID, A NOVEL COMPOUND FROM CIVET (VIVERRA CIVETTA)
Authors: MAURER B. , GRIEDER A. , THOMMEN W. 
Published: April 2016

AbstractDie Synthese der aus dem Drüsensekret von Viverra civetta isolierten Titelverbindung (IVb) wird beschrieben.
Phase 2 study of stereotactic body radiotherapy and optional transarterial chemoembolization for solitary hepatocellular carcinoma not amenable to resection and radiofrequency ablation
Authors: Takeda Atsuya , Sanuki Naoko , Tsurugai Yuichiro , Iwabuchi Shogo , Matsunaga Kotaro , Ebinuma Hirotoshi , Imajo Kento , Aoki Yousuke , Saito Hidetsugu , Kunieda Etsuo 
Published: April 2016

BACKGROUNDCurative treatment options for patients with early stage hepatocellular carcinoma (HCC) include resection, liver transplantation, and percutaneous ablation therapy. However, even patients with solitary HCC are not always amenable to these treatments. The authors prospectively investigated the clinical outcomes of patients who received stereotactic body radiotherapy (SBRT) for solitary HCC.METHODSA phase 2 study involving SBRT and optional transarterial chemoembolization (TACE) was conducted in patients with Child‐Pugh grade A or B and underlying, solitary HCC (greatest tumor dimension, ≤4 cm) who were unsuitable candidates for resection and radiofrequency ablation. The prescription dose was 35 to 40 grays in 5 fractions. The primary endpoint was 3‐year local tumor control.RESULTSFrom 2007 to 2012, 101 patients were enrolled, and 90 were evaluable with a median follow‐up of 41.7 months (range, 6.8‐96.2 months). Thirty‐two patients were treatment‐naïve, 20 were treated for newly diagnosed intrahepatic failure, and 38 were treated for residual or recurrent HCC as salvage therapy. Thirty‐two patients did not receive TACE, 48 received insufficient TACE, and 10 attained full lipiodol accumulation. The 3‐year local control rate was 96.3%, the 3‐year liver‐related cause‐specific survival rate was 72.5%, and the overall survival rate was 66.7%. Grade 3 laboratory abnormalities were observed in 6 patients, and 8 patients had Child‐Pugh scores that worsened by 2 points.CONCLUSIONSSBRT achieved high local control and overall survival with feasible toxicities for patients with solitary HCC, despite rather stringent conditions. SBRT can be effective against solitary HCC in treatment‐naive, intrahepatic failure, residual disease, and recurrent settings, taking advantage of its distinctive characteristics. Cancer 2016;122:2041–9. © 2016 American Cancer Society.
Absence of Infinite Cluster for Critical Bernoulli Percolation on Slabs
Authors: Duminil Hugo , Sidoravicius Vladas , Tassion Vincent 
Published: April 2016

AbstractWe prove that for Bernoulli percolation on a graph , there is no infinite cluster at criticality, almost surely. The proof extends to finite‐range Bernoulli percolation models on ℤ2 that are invariant under ‐rotation and reflection.© 2016 Wiley Periodicals, Inc.
Heparin reduces nonspecific eosinophil staining artifacts in mass cytometry experiments
Authors: Rahman Adeeb H. , Tordesillas Leticia , Berin M. Cecilia 
Published: April 2016

AbstractThe analysis of heterogeneous cell samples by mass cytometry (CyTOF) relies on the assumption that metal labeled antibodies accurately bind to their target antigens. We report a previously unappreciated experimental artifact of non‐specific antibody binding by eosinophils during intracellular CyTOF analysis of human whole blood samples. We hypothesized that this non‐specific binding results from a charge‐based interaction between the metal‐labeled antibodies and highly cationic proteins found in eosinophillic granules and found that this non‐specific staining artifact could be reduced to background levels with a simple blocking protocol using heparin as a competing anionic protein. This protocol eliminates a potential source of erroneous data interpretation in all experiments involving intracellular staining of human whole blood samples, and allows accurate assessment of dynamic changes in intracellular proteins in eosinophils by CyTOF. © 2016 International Society for Advancement of Cytometry
Predictors of initiation and persistence of recurrent binge eating and inappropriate weight compensatory behaviors in college men
Authors: Dakanalis Antonios , Clerici Massimo , Caslini Manuela , Gaudio Santino , Serino Silvia , Riva Giuseppe , Carrà Giuseppe 
Published: April 2016

ABSTRACTObjectiveThe transition to college is considered as a risk period for the development of behavioral symptoms of eating disorders (BSEDs) and some evidence suggests that, amongst men, these symptoms occurring on a regular basis remain relatively stable over the college period. Nevertheless, little is known about factors associated with persistent engagement in and initiation of recurrent (or regular) binge eating and inappropriate weight compensatory behaviors in this population. The objective of this report was to address these research gaps.MethodData were examined from 2,555 male first‐year college students who completed an assessment of potential vulnerability factors and BSEDs at the beginning of the autumn semester (baseline) and nine months later (end of the spring semester; follow‐up).ResultsElevated negative affectivity, body dissatisfaction, self‐objectification, and lower self‐esteem at baseline were predictive of persistent engagement in regular binge eating and four compensatory behaviors (self‐induced vomiting, laxative/diuretic abuse, fasting, exercise) at follow‐up, as well as initiation of all these behaviors occurring regularly (i.e., at least weekly for 3 months). Self‐objectification (thinking and monitoring the body's outward appearance from a third‐person perspective) emerged as the largest contributor of both the initiation and persistence of all behavioral symptoms.DiscussionData emphasize that the same psychological factors underlie initiation and persistence of recurrent BSEDs and should shape the focus of future interventions for college men. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:581–590)
Cardiac device therapy in patients with left ventricular dysfunction and heart failure: ‘real‐world’ data on long‐term outcomes (mortality, hospitalizations, days alive and out of hospital)
Authors: Boriani Giuseppe , Berti Elena , Belotti Laura Maria Beatrice , Biffi Mauro , De Palma Rossana , Malavasi Vincenzo L. , Bottoni Nicola , Rossi Luca , De Maria Elia , Mantovan Roberto , Zardini Marco , Casali Edoardo , Marconi Marco , Bandini Alberto , Tomasi Corrado , Boggian Giulio , Barbato Gaetano , Toselli Tiziano , Zennaro Mauro , Sassone Biagio ,   on behalf of RERAI (Registry of Emilia Romagna on Arrhythmia Interventions) Investigators
Published: April 2016

BackgroundThe impact on long‐term outcomes of implantable cardioverter defibrillators (ICDs) and biventricular defibrillators for cardiac resynchronization (CRT‐D) devices in ‘real world’ patients with heart failure (HF) needs to be assessed in terms of clinical effectiveness.Methods and resultsA registry including consecutive HF patients who underwent a first implant of an ICD (891 patients) or a CRT‐D device (709 patients) in 2006–2010 was followed (median 1487 days and 1516 days, respectively), collecting administrative data on survival, all‐cause hospitalizations, cardiovascular or HF hospitalizations, and days alive and out of hospital (DAOH). Survival free from death/cardiac transplant was 61.9% and 63.8% at 5 years for ICD and CRT‐D patients, respectively. Associated comorbidities (Charlson Comorbidity Index) had a significant impact on death/cardiac transplant, as well as on hospitalizations. The median values of DAOH% were 97.4% for ICD and 97.7% for CRT‐D patients, but data were highly skewed, with the lower quartile of DAOH% values including values ranging between 0% and 52.8% for ICD and between 0% and 56.1% for CRT‐D patients. Charlson Comorbidity Index was a very strong predictor of DAOH%.ConclusionsPatients who were implanted in ‘real world’ clinical practice with an ICD or a CRT‐D device have, on average, a relatively favourable outcome, with a survival of around 62–64% at 5 years, but with an important burden of hospitalizations. Comorbidities, as evaluated by means of the Charlson Comorbidity Index, have a significant impact on outcomes in terms of mortality/heart transplant, hospitalizations and days spent alive and out of hospital.
Treatment history and placebo responses to experimental and clinical pain in chronic pain patients
Authors: Müller M. , Kamping S. , Benrath J. , Skowronek H. , Schmitz J. , Klinger R. , Flor H. 
Published: April 2016

AbstractBackgroundPlacebo analgesia refers to the reduction in pain due to the administration of an inert treatment. It is induced by expectations of pain relief which are enhanced by learning mechanisms. In healthy humans, prior positive experiences enhance the placebo response. However, the effects of patients' prior experiences with treatment on placebo responses have not yet been examined. This study investigated how verbal information, learning and treatment history influence the magnitude of placebo analgesia in chronic pain.MethodsWe administered a pharmacological placebo intervention in a sample of chronic pain patients (n = 49) who were seeking treatment in an outpatient pain clinic. Analyses were based on placebo responders.ResultsWe found that verbal information about a potent pain‐relieving effect of the intervention induced a large placebo analgesic response to both acute experimental (F(1,44) = 43.35, p < 0.001) and chronic pain (F(1,44) = 37.72, p < 0.001). However, the placebo responses to experimental and chronic pain were not significantly related (r = 0.012, p = 0.95). An additional conditioning procedure did not significantly enhance placebo analgesia. Treatment history modulated the magnitude of the placebo response: patients with a more negative pain‐related treatment history reported significantly larger placebo responses to their own chronic pain (τ = 0.271, p = 0.044).ConclusionsWe could show that placebo responses to both acute and chronic pain are high in pain treatment settings and that treatment history modulates this effect. Different mechanisms might underlie placebo responses to acute and chronic pain. Our findings highlight the necessity of considering placebo responses and treatment history in the treatment of chronic pain.What does this study add?

Placebo analgesia following verbal information of potent pain relief is high in chronic pain patients in a clinical setting.

It is modulated by treatment history.

Different mechanisms might underlie placebo analgesia to acute and chronic pain.
RETRACTED: A convenient guideline to determine if two Y‐STR profiles are from the same lineage
Authors: Liu Hai , Li Xiaoyang , Mulero Julio , Carbonaro Andrea , Short Marc , Ge Jianye 
Published: April 2016

Y chromosome STR loci are used in forensics primarily for identification purposes by determining the male lineages. The Henan province in China has established a large Y‐STR (>200 000 profiles) database for criminal investigations. A large proportion of the Y‐STR profiles in the database were generated using either the Applied Biosystems Yfilerۛ or Yfilerۛ Plus PCR Amplification kits. The additional loci in the Yfiler Plus kit as compared to the Yfiler kit results in a concomitant cumulative mutation rate increase across the loci. Therefore, in those cases when two profiles have one to a few mismatched loci, it is difficult to determine if they are from the same lineage. In this study, 7405 unrelated male profiles were manually selected from the database. Analysis showed higher power of discrimination than the corresponding Yfiler haplotypes. Further, the distributions of the number of mismatched loci and the mismatched steps were generated for father‐son, grandfather‐grandson, uncle‐nephew, and cousins (i.e. one, two, three, and four meioses, respectively) by exhaustive pairwise comparison of the unrelated profiles using a dynamic programming approach. The same distributions were generated for unrelated pairs with mutation rates of the loci. With the distributions, the false negative and false positive rates were determined. Two Yfiler profiles with ≤2 mismatched loci or ≤2 steps are more likely from the same lineage than unrelated lineages, and two Yfiler Plus profiles with ≤4 mismatched loci or ≤5 mismatched steps are more likely from the same lineage.
Are Weight Status and Cognition Associated? An Examination of Cognitive Development in Children and Adolescents with Anorexia Nervosa 1 Year after First Hospitalisation
Authors: Kjærsdam Telléus Gry , Fagerlund Birgitte , Jepsen Jens Richardt , Bentz Mette , Christiansen Eva , Valentin Jan Brink , Thomsen Per Hove 
Published: April 2016

AbstractObjectiveThe aim of this study was to characterise the association between the cognitive profile and weight restoration in children and adolescents with anorexia nervosa.MethodsThe study was a longitudinal, matched case–control, multicentre study. An assessment of cognitive functions was conducted by using the Wechsler Intelligence Scale for Children–III/the Wechsler Adult Intelligence Scale–III, the Test of Memory and Learning–second edition, Trail Making Tests A and B, the Rey–Osterrieth Complex Figure Test and the Cambridge Neuropsychological Test Automated Battery.ResultsOne hundred twenty individuals, 60 patients with anorexia nervosa with mean age of 14.65 (SD 1.820) years and 60 healthy controls with mean age of 14.76 (SD 1.704) years, participated. No association was found between weight recovery and cognitive functions. However, a significant increase in motor speed was found in Trail Making Test A (p = 0.004), Reaction Time (RTI) five‐choice movement time (p = 0.002) and RTI simple movement time (p = 0.011), resulting in a normalisation corresponding to that found in healthy controls. Furthermore, a significantly lower score in the perceptual organization index (p = 0.029) was found at follow‐up.ConclusionsWeight recovery appears not to be associated with cognition. Copyright © 2016 The Authors European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd
Effects of white matter integrity and brain volumes on late life depression in the Framingham Heart Study
Authors: Qiu Wei Qiao , Himali Jayandra J. , Wolf Philip A. , DeCarli D. Charles , Beiser Alexa , Au Rhoda 
Published: April 2016

BackgroundIt is unclear whether brain white matter hyperintensities (WMHI) causes or is a result of late life depression. We used the Framingham Heart Study offspring to examine whether indices of brain aging are related to incident depression in the elderly.MethodsThe Center for Epidemiologic Studies Depression Scale (CES‐D) was administered along with a brain MRI scan at baseline and was re‐administered (n = 1212) at an average 6.6 + 0.6 year follow‐up. The outcomes (i) change in CES‐D scores from baseline; (ii) depression defined as CES‐D ≥16; (iii) severe depression defined as CES‐D ≥21; and (iv) CES‐D cutoff scores and/or on antidepressant were used.ResultsAmong those who did not have depression at baseline, 9.1% (n = 110) developed depression, 4.0% (n = 48) developed severe depressive symptoms, and 11.1% (n = 135) were put on antidepressants. When depressive symptoms only was the outcome, we found that baseline WMHI was positively associated with change in CES‐D scores and that those with an extensive WMHI at baseline had a high risk of developing severe depressive symptoms; the relationship was strengthened in the absence of cardiovascular diseases. In contrast, when depressive symptoms or taking antidepressant was the outcome, larger total cerebral brain volume and temporal lobe brain volume, but not WMHI, were negatively associated with the development of depression.ConclusionsBrain WMHI is a probable risk factor for vascular depression in the elderly. The depression outcomes with and without antidepressant were related to different brain pathologies. Copyright © 2016 John Wiley & Sons, Ltd.
Functional connectivity and information flow of the respiratory neural network in chronic obstructive pulmonary disease
Authors: Yu Lianchun , De Mazancourt Marine , Hess Agathe , Ashadi Fakhrul R. , Klein Isabelle , Mal Hervé , Courbage Maurice , Mangin Laurence 
Published: April 2016

AbstractBreathing involves a complex interplay between the brainstem automatic network and cortical voluntary command. How these brain regions communicate at rest or during inspiratory loading is unknown. This issue is crucial for several reasons: (i) increased respiratory loading is a major feature of several respiratory diseases, (ii) failure of the voluntary motor and cortical sensory processing drives is among the mechanisms that precede acute respiratory failure, (iii) several cerebral structures involved in responding to inspiratory loading participate in the perception of dyspnea, a distressing symptom in many disease. We studied functional connectivity and Granger causality of the respiratory network in controls and patients with chronic obstructive pulmonary disease (COPD), at rest and during inspiratory loading. Compared with those of controls, the motor cortex area of patients exhibited decreased connectivity with their contralateral counterparts and no connectivity with the brainstem. In the patients, the information flow was reversed at rest with the source of the network shifted from the medulla towards the motor cortex. During inspiratory loading, the system was overwhelmed and the motor cortex became the sink of the network. This major finding may help to understand why some patients with COPD are prone to acute respiratory failure. Network connectivity and causality were related to lung function and illness severity. We validated our connectivity and causality results with a mathematical model of neural network. Our findings suggest a new therapeutic strategy involving the modulation of brain activity to increase motor cortex functional connectivity and improve respiratory muscles performance in patients. Hum Brain Mapp 37:2736–2754, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.