bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Long‐Term Chronic Myeloid Leukemia Treatment Practices with Tyrosine Kinase Inhibitors in a National Cohort of Veterans
Authors: Kreys Eugene D. , Frei Christopher R. , Villarreal Sarah M. , Bollinger Mary J. , Jones Xavier , Koeller Jim M. 
Published: January 2017

Study ObjectiveTo evaluate nationwide chronic myeloid leukemia (CML) treatment practices over an extended period and across multiple lines of tyrosine kinase inhibitor (TKI) therapy with imatinib, dasatinib, and nilotinib.DesignRetrospective cohort study.Data SourceVeterans Health Administration (VHA) national database.PatientsA total of 2873 VHA beneficiaries aged 18–89 years who had at least one encounter at any of the ~150 VHA hospitals and 800 VHA clinics, had a diagnosis code for CML, and filled at least one prescription for imatinib, nilotinib, or dasatinib between October 1, 2001, and September 30, 2010.Measurement and Main ResultsThe VHA database was used for the time period of October 1, 2000, to September 30, 2012, allowing for a 1‐year observation period to identify CML treatments prior to study enrollment and a minimum of a 2‐year follow‐up period to assess study end points. Primary study end points included change in TKI treatment, gaps in TKI treatment, TKI treatment persistence, and patient survival. Persistence for each distinct line of treatment was defined as the time of continuous therapy, quantified by the number of days covered by the drug from treatment initiation until a 60‐day gap in treatment was identified or a switch in treatment occurred. A Kaplan‐Meier model was used to evaluate persistence and survival. Of the 2873 patients receiving first‐line TKI treatment, 586 (20.4%) switched to a different TKI, constituting second‐line treatment. Overall, 245 patients (8.5%) were switched again to third‐line treatment. Only 4.4% of patients receiving first‐line treatment experienced a gap in therapy of 60 or more days. First‐line treatment persistence rates were 75%, 65%, and 55% for the first, second, and third years of treatment, respectively. Five‐year survival with first‐line treatment was 62%.ConclusionIn this national cohort of VHA patients, 1‐year persistence of first‐line TKI treatment was similar to that in prior studies. Five‐year survival was comparable with that in other observational studies but was lower than that in prospective clinical trials. Persistence rates declined after the introduction of the new TKIs.
Optimal single‐electron feedback control
Authors: Wagner Timo , Bayer Johannes C. , Rugeramigabo Eddy P. , Haug Rolf J. 
Published: January 2017

AbstractIn a closed‐loop controlled single‐electron transistor (SET) the optimal feedback response is investigated, leading to a maximum suppression of shot‐noise. Using a coupled quantum point contact (QPC) charge detector, the tunneling process is monitored in real‐time and the fluctuations are fed back periodically to the tunneling barriers of the SET. The feedback response is applied proportional to the deviation from the target number of average transferred electrons. This leads to a strong suppression and temporal saturation of the cumulants of the full counting statistics. For the optimal feedback response, the saturation value of second cumulant is found to be given by target number. Astonishingly, the feedback works robust even for target numbers much smaller than one.
Strength through adversity: Moderate lifetime stress exposure is associated with psychological resilience in breast cancer survivors
Authors: Dooley Larissa N. , Slavich George M. , Moreno Patricia I. , Bower Julienne E. 
Published: January 2017

AbstractStress research typically emphasizes the toxic effects of stress, but recent evidence has suggested that stress exposure, in moderation, can facilitate resilience. To test whether moderate stress exposure promotes psychological resilience to cancer, we examined the relationship between lifetime stress exposure prior to cancer diagnosis and postdiagnosis psychological functioning among 122 breast cancer survivors. Lifetime acute and chronic stress was assessed using an interview‐based measure, and psychological functioning was assessed using measures of cancer‐related intrusive thoughts and positive and negative affect. Results indicated that acute stress exposure was associated with cancer‐related intrusive thoughts in a quadratic fashion (p = .016), such that participants with moderate acute stress reported fewer intrusive thoughts compared to those with low or high acute stress. Similarly, a quadratic relationship emerged between acute stress exposure and positive affect (p = .009), such that individuals with moderate acute stress reported the highest levels of positive affect. In contrast, acute and chronic stress were related to negative affect in a positive, linear fashion (ps < .05). In conclusion, moderate stress exposure was associated with indicators of psychological resilience among breast cancer survivors, supporting stress exposure as a key factor influencing adjustment to breast cancer and providing evidence for stress‐induced resilience in a novel population.
Reliability of 1H NMR Analysis for Assessment of Lipid Oxidation at Frying Temperatures
Authors: Hwang Hong‐Sik , Winkler‐Moser Jill K. , Liu Sean X. 
Published: January 2017

AbstractThe reliability of a method using 1H NMR analysis for assessment of oil oxidation at frying temperatures was examined. During heating and frying at 180 °C, changes of soybean oil signals in the 1H NMR spectrum including olefinic (5.16–5.30 ppm), bisallylic (2.70–2.88 ppm), and allylic (1.94–2.15 ppm) proton signals relative to glyceride backbone CH2 (5.30–5.46 ppm) and aliphatic CH2 (1.05–1.71 ppm) signals showed strong correlations with conventional analytical methods including total polar compounds, polymerized triacylglycerols, and changes of linoleic acid and linolenic acid peaks in gas chromatography. For oils rich in oleic acid, mid‐oleic sunflower oil (NuSun) and high oleic soybean oil, only the olefinic and allylic proton signals are recommended for analysis due to the relatively low intensity of the bisallylic proton signal. Under these heating and frying conditions, signals indicating intermediate oxidation products, hydroperoxides, were not detected while very small signals corresponding to a variety of aldehydes including alkanal, branched alkenal, 2‐alkenal, and aldehydes of conjugated dienes and epoxides were observed. In this study, it was found that the 1H NMR method is a fast, convenient, and reliable analytical method to determine the oxidation state of frying oil.
Women’s Short-Term Employment Trajectories Following Birth: Patterns, Determinants, and Variations by Race/Ethnicity and Nativity
Authors: Lu Yao , Wang Julia Shu-Huah , Han Wen-Jui 
Published: January 2017

Abstract
Despite a large literature documenting the impact of childbearing on women’s wages, less understanding exists of the actual employment trajectories that mothers take and the circumstances surrounding different paths. We use sequence analysis to chart the entire employment trajectory for a diverse sample of U.S. women by race/ethnicity and nativity in the first year following childbirth. Using data from the 1996–2008 panels of the Survey of Income and Program Participation and sample selection models, we find that women employed before childbirth show a high degree of labor market continuity. However, a notable share of them (24 %) took less stable paths by dropping out or scaling back work. In addition, mothers’ attachment to the labor force is simultaneously supported by personal endowments and family resources yet constrained by economic hardship and job characteristics. Moreover, mothers’ employment patterns differ by race/ethnicity and nativity. Nonwhite women (blacks, Hispanics, and Asians) who were employed before childbirth exhibited greater labor market continuation than white women. For immigrant women, those with a shorter length of residence were more likely to curtail employment than native-born women, but those with longer duration of residence show greater labor force attachment. We discuss the implications of these findings for income inequality and public policy.
Childhood trauma and psychotic experiences in a general population sample: A prospective study on the mediating role of emotion regulation
Authors: Lincoln T.M. , Marin N. , Jaya E.S. 
Published: January 2017

AbstractBackgroundThe causal role of childhood trauma for psychosis is well established, but the mechanisms that link trauma to psychosis are largely unknown. Since childhood trauma is known to cause difficulties in emotion regulation (ER) and patients with psychosis show impaired ER, we hypothesize that impaired ER explains why people with a background of trauma are prone to psychotic experiences.MethodsThe study used a longitudinal cohort design based on a community sample (N = 562) from Germany, Indonesia, and the United States. Childhood trauma was assessed at baseline. ER and psychotic experiences (defined as positive symptom frequency and related distress) were measured repeatedly at a 4-, 8-, and 12-month follow-up. Cross-lagged panel and longitudinal mediation analyses with structural equation modeling were used to test the predictive value of ER on psychotic experiences and its mediating role in the association of childhood trauma and psychotic experiences.ResultsThe cross-lagged paths from impaired ER to symptom distress (but not frequency) were significant. However, there was also evidence for the reverse causation from symptom frequency and distress to impaired ER. ER partially mediated the significant prospective paths from childhood trauma to symptom distress.ConclusionThe findings demonstrate that ER plays a role in translating childhood trauma into distressing psychotic experiences in later life. Moreover, the findings point to a maintenance mechanism in which difficulties in ER and symptom distress exacerbate each other. Thus, ER could be a promising target for interventions aimed at prevention of psychosis.
Mass changes of alpine glaciers at the eastern margin of the Northern and Southern Patagonian Icefields between 2000 and 2012
Authors: FALASCHI DANIEL , BOLCH TOBIAS , RASTNER PHILIPP , LENZANO MARÍA GABRIELA , LENZANO LUIS , LO VECCHIO ANDRÉS , MORAGUES SILVANA 
Published: January 2017

ABSTRACTDespite renewed efforts to better understand glacier change and recognize glacier change trends in the Andes, relatively large areas in the Andes of Argentina and Chile are still not investigated. In this study, we report on glacier elevation and mass changes in the outer region of the Northern and Southern Patagonian Icefields in the Southern Patagonian Andes. A newly-compiled Landsat ETM+ derived glacier inventory (consisting of 2253 glaciers and ~1314 ± 66 km2of ice area) and differencing of the SRTM and SPOT5 DEMs were used to derive glacier-specific elevation changes over the 2000–12 period. The investigated glaciers showed a volume change of −0.71 ± 0.55 km3a−1, yielding a surface lowering of 0.52 ± 0.35 m a−1on average and an overall mass loss of 0.46 ± 0.37 m w.e. a−1. Highly variable individual glacier responses were observed and interestingly, they were less negative than previously reported for the neighboring Patagonian Icefields.
The Growth Stop Phenomenon Of Baobabs (Adansonia Spp.) Identified By Radiocarbon Dating
Authors: Patrut Adrian , Woodborne Stephan , von Reden Karl F , Hall Grant , Patrut Roxana T , Rakosy Laszlo , Danthu Pascal , Pock-Tsy Jean-Michel Leong , Lowy Daniel A , Margineanu Dragos 
Published: January 2017

AbstractThe article reports the growth stop phenomenon, which was documented only for baobabs, i.e. for trees belonging to the Adansonia genus. The identification of growth stop was enabled by radiocarbon dating, which allows a complex investigation of samples collected from the trunk/stems of baobabs. In several cases, the outermost rings of baobabs, which were close to the bark, were found to be old, with ages of several hundreds of years, instead of being very young. Dating results of samples collected from six baobabs are presented. For multistemmed baobabs, the growth stop may occur only for one or several stems. We identified four factors that may induce the growth stop: (i) stress determined by severe climate conditions, (ii) old age, (iii) the need to keep a stable internal architecture, and (iv) the collapse of stems that survive this trauma. Baobabs and their stems affected by growth stop may survive for several centuries, by continuing to produce leaves, flowers, and fruits. This phenomenon was associated with the capacity of baobabs to store large amounts of water in their trunks/stems in the rainy season. This reservoir of water is used during the dry season and allows the trees to survive prolonged drought periods.
Ion reflection by shock waves and pulse generation by cross-field ion beams
Authors: Ohsawa Yukiharu 
Published: January 2017

Comparisons are made of two different particle simulations: one for the study of plasma-based accelerators (Gueroult & Fisch, Phys. Plasmas, vol. 23, 2016, 032113) and the other for the study of shock formation in the interstellar medium (Yamauchi & Ohsawa, Phys. Plasmas, vol. 14, 2007, 053110). In the former, shock waves used for plasma density control create ion beams by reflection. In the latter, a fast and dense beam of exploding ions penetrates a surrounding plasma. In both simulations, magnetic bumps are generated from the motion of ion beams perpendicular to a magnetic field. Despite the apparent differences of their purposes, configurations and spatial scales, the two simulations show strong similarities in the generation processes and effects of the bumps, suggesting that these are not rare plasma phenomena. The bump created by the exploding ions develops into backward and forward magnetosonic pulses.
What Drives Institutional Reforms in Regional Organisations? Diffusion, Contextual Conditions, and the Modular Design of ASEAN
Authors: Jetschke Anja 
Published: January 2017

AbstractWhat drives institutional reforms in regional organisations? And what explains the institutional design of ASEAN? Despite many differences, conventional approaches to the institutional design of regional organisations more generally and ASEAN in particular are united in regarding them as either determined by factors endogenous to the region − such as varying state interests or collective norms − or as exogenously driven, most importantly by hegemonic states like the US or China. This article offers a diffusion account of ASEAN's institutional design. Building on a more recent strand in the diffusion literature emphasising that diffusion rarely leads to convergence, the article makes two genuine contributions. First, it argues that members of regional organisations engage in modular adoption: they select institutional templates from a variety of regional as well as international organisations thereby taking advantage of available information on the costs and benefits of alternative institutions. Second, it argues that contextual conditions and cognitive priors influence what templates are chosen. The argument will be illustrated with a case study on ASEAN's adoption of a single market and a dispute settlement mechanism. Finally, and contrary to arguments that institutional borrowing might increase the expectations-deliverance gap within regional organisations, it argues that if conducted consistently, modular adoption can lead to substantial innovation and success.
Dimensions of the Rorschach Comprehensive System
Authors: Fontan Patrick , Andronikof Anne , Mattlar Carl-Erik , Mormont Christian 
Published: January 2017

Abstract. The objective of this study is to propose a preliminary comprehensive dimensional model of the Rorschach Comprehensive System (RCS). Three European adult nonpatient samples of the RCS were combined (Belgium, France, and Finland, N = 695). Principal component analysis was performed on primary scoring categories. Distribution issues were addressed by rank order transformation and the problem of R by partial correlations. The number of Components was determined through Parallel Analysis and resampling techniques (bootstrap and permutation). Twelve Components eigenvalues differed significantly from chance level (p < 0.0001). The obtained model provides a simplified representation of RCS data which accounts for 43% of the variance. This model brings new insights: Some variables traditionally considered as related belong to independent dimensions, and some others considered as independent appear related. These preliminary results set the stage for a new psychometrical approach of the RCS.
Electromagnetic polarization-controlled perfect switching effect with high-refractive-index dimers and the beam-splitter configuration
Authors: Barreda Ángela I. , Saleh Hassan , Litman Amelie , González Francisco , Geffrin Jean-Michel , Moreno Fernando 
Published: January 2017

AbstractSub-wavelength particles made from high-index dielectrics, either individual or as ensembles, are ideal candidates for multifunctional elements in optical devices. Their directionality effects are traditionally analysed through forward and backward measurements, even if these directions are not convenient for in-plane scattering practical purposes. Here we present unambiguous experimental evidence in the microwave range that for a dimer of HRI spherical particles, a perfect switching effect is observed out of those directions as a consequence of the mutual particle electric/magnetic interaction. The binary state depends on the excitation polarization. Its analysis is performed through the linear polarization degree of scattered radiation at a detection direction perpendicular to the incident direction: the beam-splitter configuration. The scaling property of Maxwell’s equations allows the generalization of our results to other frequency ranges and dimension scales, for instance, the visible and the nanometric scale.
Metabolic pathway for a new strain Pseudomonas synxantha LSH-7′: from chemotaxis to uptake of n-hexadecane
Authors: Meng Long , Li Haoshuai , Bao Mutai , Sun Peiyan 
Published: January 2017

AbstractBacteria can use n-hexadecane as a carbon source, but it remains incompletely understood whether n-hexadecane is transformed into metabolic intermediates prior to cellular uptake or not. We newly isolated a strain identified as Pseudomonas synxantha LSH-7′ and conducted chemotaxis experiment of this bacterial strain towards n-hexadecane, hexadecanol and hexadecanoic acid with qualitative assays respectively. Furthermore, we described the identification of extracellular alkane hydroxylase and alcohol dehydrogenase activity; acidification of the culture medium; identification of hexadecanoic acid in the culture medium by the GC-MS analysis; and variation concentration of intracellular n-hexadecane and hexadecanoic acid. A detailed analysis of the experimental data revealed the chemotaxis of this bacterial strain towards n-hexadecane instead of its metabolic intermediates. Our results further suggested that only a fraction of total n-hexadecane followed this path, and alkane hydrolase and hexadecanol dehydrogenase were constitutively expressed when grown in the medium of n-hexadecane. Most strikingly, we quantitatively investigated the concentration of n-hexadecane adsorbed by bacterial chemotaxis. Our findings provided an original insight n-hexadecane might be converted to hexadecanoic acid extracellularly before it was taken up across the cell membrane.
A Light-Responsive Self-Assembly Formed by a Cationic Azobenzene Derivative and SDS as a Drug Delivery System
Authors: Geng Shengyong , Wang Yuzhu , Wang Liping , Kouyama Tsutomu , Gotoh Toshiaki , Wada Satoshi , Wang Jin-Ye 
Published: January 2017

AbstractThe structure of a self-assembly formed from a cationic azobenzene derivative, 4-cholesterocarbonyl-4′-(N,N,N-triethylamine butyloxyl bromide) azobenzene (CAB) and surfactant sodium dodecyl sulfate (SDS) in aqueous solution was studied by cryo-TEM and synchrotron radiation small-angle X-ray scattering (SAXS). Both unilamellar and multilamellar vesicles could be observed. CAB in vesicles were capable to undergo reversible trans-to-cis isomerization upon UV or visible light irradiation. The structural change upon UV light irradiation could be catched by SAXS, which demonstrated that the interlamellar spacing of the cis-multilamellar vesicles increased by 0.2–0.3 nm. Based on this microstructural change, the release of rhodamine B (RhB) and doxorubicin (DOX) could be triggered by UV irradiation. When incubated NIH 3T3 cells and Bel 7402 cells with DOX-loaded CAB/SDS vesicles, UV irradiation induced DOX release decreased the viability of both cell lines significantly compared with the non-irradiated cells. The in vitro experiment indicated that CAB/SDS vesicles had high efficiency to deliver loaded molecules into cells. The in vivo experiment showed that CAB/SDS vesicles not only have high drug delivery efficiency into rat retinas, but also could maintain high drug concentration for a longer time. CAB/SDS catanionic vesicles may find potential applications as a smart drug delivery system for controlled release by light.
A comprehensive custom panel design for routine hereditary cancer testing: preserving control, improving diagnostics and revealing a complex variation landscape
Authors: Castellanos Elisabeth , Gel Bernat , Rosas Inma , Tornero Eva , Santín Sheila , Pluvinet Raquel , Velasco Juan , Sumoy Lauro , del Valle Jesús , Perucho Manuel , Blanco Ignacio , Navarro Matilde , Brunet Joan , Pineda Marta , Feliubadaló Lidia , Capellá Gabi , Lázaro Conxi , Serra Eduard 
Published: January 2017

AbstractWe wanted to implement an NGS strategy to globally analyze hereditary cancer with diagnostic quality while retaining the same degree of understanding and control we had in pre-NGS strategies. To do this, we developed the I2HCP panel, a custom bait library covering 122 hereditary cancer genes. We improved bait design, tested different NGS platforms and created a clinically driven custom data analysis pipeline. The I2HCP panel was developed using a training set of hereditary colorectal cancer, hereditary breast and ovarian cancer and neurofibromatosis patients and reached an accuracy, analytical sensitivity and specificity greater than 99%, which was maintained in a validation set. I2HCP changed our diagnostic approach, involving clinicians and a genetic diagnostics team from panel design to reporting. The new strategy improved diagnostic sensitivity, solved uncertain clinical diagnoses and identified mutations in new genes. We assessed the genetic variation in the complete set of hereditary cancer genes, revealing a complex variation landscape that coexists with the disease-causing mutation. We developed, validated and implemented a custom NGS-based strategy for hereditary cancer diagnostics that improved our previous workflows. Additionally, the existence of a rich genetic variation in hereditary cancer genes favors the use of this panel to investigate their role in cancer risk.
Sequence specific sorting of DNA molecules with FACS using 3dPCR
Authors: Sukovich David J. , Lance Shea T. , Abate Adam R. 
Published: January 2017

AbstractGenetic heterogeneity is an important feature of many biological systems, but introduces technical challenges to their characterization. Even with the best modern instruments, only a small fraction of DNA molecules present in a sample can be read, and they are recovered in the form of short, hundred-base reads. In this paper, we introduce 3dPCR, a method to sort DNA molecules with sequence specificity. 3dPCR allows heterogeneous populations of DNA to be sorted to recover long targets for deep sequencing. It is valuable whenever a target sequence is rare in a mixed population, such as for characterizing mutations in heterogeneous cancer cell populations or identifying cells containing a specific genetic sequence or infected with a target virus.