bluuebunny/crossref_metadata_2025_split huggingface dataset:
SERNOTATE: An automated approach for business service description annotation for efficient service retrieval and composition
Authors: Chotipant Supannada , Hussain Farookh Khadeer , Hussain Omar Khadeer 
Published: June 2017

SummaryBusiness service advertisements are today published online to convey essential information about services to customers. However, current Web search engines are unable to search and combine online service advertisements. Semantic service annotation is important for its ability to enable machines to understand the meaning of services and support in effective service retrieval and service composition. Existing research in the area of semantic service annotation has focused on the annotation of Web services in a semi‐automated approach. It cannot be applied to business service information as it is not in the form of Web Services Description Language but in free text format. Moreover, semi‐automated approaches are inappropriate for annotating a large amount of online service information which changes dynamically and they are therefore not suitable for the timely dissemination of service information to customers. To solve these issues, we propose SERNOTATE, which is an automated approach for business service description annotation for efficient service retrieval and composition. We propose new semantic‐based linking approaches, namely, Extended Case‐based Reasoning, vector‐based, and classification‐based, that automatically annotate business services to relevant service concepts. Each approach assists in the single‐label and multi‐label annotation of service terms to concept terms to provide a better representation of services. The experimental results test and validate the applicability of the proposed approaches to the automatic annotation of business service descriptions to service concepts on a real‐world dataset.
Manipulation of habitat isolation and area implicates deterministic factors and limited neutrality in community assembly
Authors: Ord Terry J. , Emblen Jack , Hagman Mattias , Shofner Ryan , Unruh Sara 
Published: June 2017

AbstractTheory predicts deterministic and stochastic factors will contribute to community assembly in different ways: Environmental filters should regulate those species that establish in a particular area resulting in the ecological requirements of species being the primary driver of species distributions, while chance and dispersal limitation should dictate the likelihood of species reaching certain areas with the ecology of species being largely neutral. These factors are specifically relevant for understanding how the area and isolation of different habitats or islands interact to affect community composition. Our review of the literature found few experimental studies have examined the interactive effect of habitat area and isolation on community assembly, and the results of those experiments have been mixed. We manipulated the area and isolation of rock “islands” created de novo in a grassland matrix to experimentally test how deterministic and stochastic factors shape colonizing animal communities. Over 64 weeks, the experiment revealed the primacy of deterministic factors in community assembly, with habitat islands of the same size exhibiting remarkable consistency in community composition and diversity, irrespective of isolation. Nevertheless, tangible differences still existed in abundance inequality among taxa: Large, near islands had consistently higher numbers of common taxa compared to all other island types. Dispersal limitation is often assumed to be negligible at small spatial scales, but our data shows this not to be the case. Furthermore, the dispersal limitation of a subset of species has potentially complex flow‐on effects for dictating the type of deterministic factors affecting other colonizing species.
Antibody fingerprints in lyme disease deciphered with high density peptide arrays
Authors: Weber Laura K. , Isse Awale , Rentschler Simone , Kneusel Richard E. , Palermo Andrea , Hubbuch Jürgen , Nesterov‐Mueller Alexander , Breitling Frank , Loeffler Felix F. 
Published: June 2017

AbstractLyme disease is the most common tick‐borne infectious disease in Europe and North America. Previous studies discovered the immunogenic role of a surface‐exposed lipoprotein (VlsE) of Borreliella burgdorferi. We employed high density peptide arrays to investigate the antibody response to the VlsE protein in VlsE‐positive patients by mapping the protein as overlapping peptides and subsequent in‐depth epitope substitution analyses. These investigations led to the identification of antibody fingerprints represented by a number of key residues that are indispensable for the binding of the respective antibody. This approach allows us to compare the antibody specificities of different patients to the resolution of single amino acids. Our study revealed that the sera of VlsE‐positive patients recognize different epitopes on the protein. Remarkably, in those cases where the same epitope is targeted, the antibody fingerprint is almost identical. Furthermore, we could correlate two fingerprints with human autoantigens and an Epstein‐Barr virus epitope; yet, the link to autoimmune disorders seems unlikely and must be investigated in further studies. The other three fingerprints are much more specific for B. burgdorferi. Since antibody fingerprints of longer sequences have proven to be highly disease specific, our findings suggest that the fingerprints could function as diagnostic markers that can reduce false positive test results.
Estimation of vanadium water quality benchmarks for the protection of aquatic life with relevance to the Athabasca Oil Sands region using species sensitivity distributions
Authors: Schiffer Stephanie , Liber Karsten 
Published: June 2017

Abstract

Elevated vanadium (V) concentrations in oil sands coke, which is produced and stored on site of some major Athabasca Oil Sands companies, could pose a risk to aquatic ecosystems in northern Alberta, Canada, depending on its future storage and utilization. In the present study, V toxicity was determined in reconstituted Athabasca River water to various freshwater organisms, including 2 midge species (Chironomus dilutus and Chironomus riparius; 4-d and 30-d to 40-d exposures) and 2 freshwater fish species (Oncorhynchus mykiss and Pimephales promelas; 4-d and 28-d exposures) to facilitate estimation of water quality benchmarks. The acute toxicity of V was 52.0 and 63.2 mg/L for C. dilutus and C. riparius, respectively, and 4.0 and 14.8 mg V/L for P. promelas and O. mykiss, respectively. Vanadium exposure significantly impaired adult emergence of C. dilutus and C. riparius at concentrations ≥16.7 (31.6% reduction) and 8.3 (18.0% reduction) mg/L, respectively. Chronic toxicity in fish presented as lethality, with chronic 28-d LC50s of 0.5 and 4.3 mg/L for P. promelas and O. mykiss, respectively. These data were combined with data from the peer-reviewed literature, and separate acute and chronic species sensitivity distributions (SSDs) were constructed. The acute and chronic hazardous concentrations endangering only 5% of species (HC5) were estimated as 0.64 and 0.05 mg V/L, respectively. These new data for V toxicity to aquatic organisms ensure that there are now adequate data available for regulatory agencies to develop appropriate water quality guidelines for use in the Athabasca Oil Sands region and elsewhere. Until then, the HC5 values presented in the present study could serve as interim benchmarks for the protection of aquatic life from exposure to hazardous levels of V in local aquatic environments. Environ Toxicol Chem 2017;36:3034–3044. © 2017 SETAC
Nutritional quality of Oyster Mushroom (Pleurotus Ostreatus) as affected by osmotic pretreatments and drying methods
Authors: Tolera Kumela D. , Abera Solomon 
Published: June 2017

AbstractThis study was conducted to evaluate the effects of different levels of osmotic pretreatments prior to drying and different drying methods on nutritional quality of dried mushroom slices. The experiment consisted of sun, solar, and oven drying after dipping the slices in salt solutions of 5 and 10% concentrations for 50 minutes, the control being untreated mushroom sample. Significant differences in proximate composition were observed between the fresh and dried mushroom samples. The average mean value of crude protein, crude fat, crude fiber, ash, and carbohydrates of the fresh mushroom samples were 28.85, 2.47, 12.87, 9.76 and 48.16% as compared to 25.91, 2.18, 10.41, 10.91 and 42.14% for dried samples. Oven drying resulted in higher content of ash (11.06%) and carbohydrates (43.64%) and lower contents of crude protein (24.99%), crude fat (2.12%), and crude fiber (10.21%). The osmotic pretreatments significantly affected the composition of the dried mushroom samples. As salt concentration increased from 0 to 5 and 10%, the protein content reduced from 26.78 to 25.99 and 24. 95%, the fat reduced from 2.42 to 2.19 and 1.94, and fiber from 12.82 to 9.41 and 9.01%, respectively. Contrarily, the ash increased from 9.75 to 12.20%, and the carbohydrate from 38.16 to 43.08 and 45.18%, respectively.
A genetic stochastic process model for genome‐wide joint analysis of biomarker dynamics and disease susceptibility with longitudinal data
Authors: He Liang , Zhbannikov Ilya , Arbeev Konstantin G. , Yashin Anatoliy I. , Kulminski Alexander M. 
Published: June 2017

ABSTRACTUnraveling the underlying biological mechanisms or pathways behind the effects of genetic variations on complex diseases remains one of the major challenges in the post‐GWAS (where GWAS is genome‐wide association study) era. To further explore the relationship between genetic variations, biomarkers, and diseases for elucidating underlying pathological mechanism, a huge effort has been placed on examining pleiotropic and gene‐environmental interaction effects. We propose a novel genetic stochastic process model (GSPM) that can be applied to GWAS and jointly investigate the genetic effects on longitudinally measured biomarkers and risks of diseases. This model is characterized by more profound biological interpretation and takes into account the dynamics of biomarkers during follow‐up when investigating the hazards of a disease. We illustrate the rationale and evaluate the performance of the proposed model through two GWAS. One is to detect single nucleotide polymorphisms (SNPs) having interaction effects on type 2 diabetes (T2D) with body mass index (BMI) and the other is to detect SNPs affecting the optimal BMI level for protecting from T2D. We identified multiple SNPs that showed interaction effects with BMI on T2D, including a novel SNP rs11757677 in theCDKAL1gene (P= 5.77 × 10−7). We also found a SNP rs1551133 located on 2q14.2 that reversed the effect of BMI on T2D (P= 6.70 × 10−7). In conclusion, the proposed GSPM provides a promising and useful tool in GWAS of longitudinal data for interrogating pleiotropic and interaction effects to gain more insights into the relationship between genes, quantitative biomarkers, and risks of complex diseases.
Early Carboniferous tectonic evolution of the northern Heihe–Nenjiang–Hegenshan suture zone, NE China: Constraints from the mylonitized Nenjiang rhyolites and the Moguqi gabbros
Authors: Feng Zhi‐Qiang , Li Wei‐Min , Liu Yong‐Jiang , Jin Wei , Wen Quan‐Bo , Liu Bin‐Qiang , Zhou Jian‐Ping , Zhang Tie‐An , Li Xiao‐Yu 
Published: June 2017

The Heihe–Nenjiang–Hegenshan suture zone has long been accepted as the major tectonic boundary between the Xing'an and Songliao blocks and extends through the Great Xing'an Range in NE China, but its location of the northern segment between the Moguqi and Nenjiang areas and its timing remain unclear. We address these issues by presenting zircon LA‐ICP‐MS U–Pb ages, Lu‐Hf isotopes, bulk‐rock major, and trace elemental data for mylonitized rhyolites collected from the Moergenhe Formation in the Nenjiang area and for gabbros of the Moguqi area, respectively. The mylonitized rhyolites, which display an arc‐related geochemical affinity with enrichment in Th and U, and depletion of Nb, Ta, and Ti, and gently right‐tilted rare earth element (REE) patterns (light REE [LREE]/heavy REE [HREE] =4.53–7.60), as well as the εHf (t) values (+6.4 to +11.8) of analyzed zircons, indicate an origin by partial melting of potentially young lower continental crust of a subducting slab. The zircon LA‐ICP‐MS U–Pb data show the formation age of the mylonitized rhyolites is 352.4 Ma. The analyzed gabbros with an emplacement age of 352.6 Ma have high concentrations of Th and U, slightly enriched LREE patterns and relative low LREE/HREE ratios (4.3 to 4.6). These features, together with their high positive εHf (t) values (+7.7 to +15.2), suggest that they were likely derived from the partial melting of a depleted mantle source that was metasomatized by subduction‐related fluids. Combined with the geochemical features of the coeval igneous rocks from the northern Great Xing'an Range, these results reveal that the existence of an early Carboniferous NE‐trending magmatic arc (ca. 350–330 Ma), extending along the west of the Heihe–Nenjiang–Hegenshan suture zone, gives more constraints on the amalgamation of the Xing'an and Songliao blocks along the Nenjiang–Moguqi areas and indicates that the amalgamation should have terminated by at least the end of the early Carboniferous.
Ratiometric analysis of optical coherence tomography–measured in vivo retinal layer thicknesses for the detection of early diabetic retinopathy
Authors: Bhaduri Basanta , Shelton Ryan L. , Nolan Ryan M. , Hendren Lucas , Almasov Alexandra , Labriola Leanne T. , Boppart Stephen A. 
Published: June 2017

AbstractInfluence of diabetes mellitus (DM) and diabetic retinopathy (DR) on parafoveal retinal thicknesses and their ratios was evaluated. Six retinal layer boundaries were segmented from spectral‐domain optical coherence tomography images using open‐source software. Five study groups: (1) healthy control (HC) subjects, and subjects with (2) controlled DM, (3) uncontrolled DM, (4) controlled DR and (5) uncontrolled DR, were identified. The one‐way analyses of variance (ANOVA) between adjacent study groups (i. e. 1 with 2, 2 with 3, etc) indicated differences in retinal thicknesses and ratios. Overall retinal thickness, ganglion cell layer (GCL) thickness, inner plexiform layer (IPL) thickness, and their combination (GCL+ IPL), appeared to be significantly less in the uncontrolled DM group when compared to controlled DM and controlled DR groups. Although the combination of nerve fiber layer (NFL) and GCL, and IPL thicknesses were not different, their ratio, (NFL+GCL)/IPL, was found to be significantly higher in the controlled DM group compared to the HC group. Comparisons of the controlled DR group with the controlled DM group, and with the uncontrolled DR group, do not show any differences in the layer thicknesses, though several significant ratios were obtained. Ratiometric analysis may provide more sensitive parameters for detecting changes in DR. Picture: A representative segmented OCT image of the human retina is shown.
Evaluation of the Parent‐Report Inventory of Callous–Unemotional Traits in a Sample of Children Recruited from Intimate Partner Violence Services: A Multidimensional Rasch Analysis
Authors: McDonald Shelby Elaine , Ma Lin , Green Kathy E. , Hitti Stephanie A. , Cody Anna M. , Donovan Courtney , Williams James Herbert , Ascione Frank R. 
Published: June 2017

ObjectiveOur study applied multidimensional item response theory (MIRT) to compare structural models of the parent‐report version of the Inventory of Callous and Unemotional Traits (ICU; English and North American Spanish translations).MethodA total of 291 maternal caregivers were recruited from community‐based domestic violence services and reported on their children (77.9% ethnic minority; 47% female), who ranged in age from 7 to 12 years (mean = 9.07, standard deviation = 1.64). We compared 9 models that were based on prior psychometric evaluations of the ICU.ResultsMIRT analyses indicated that a revised 18‐item version comprising 2 factors (callous–unemotional and empathic–prosocial) was more suitable for our sample. Differential item functioning was found for several items across ethnic and language groups, but not for child gender or age. Evidence of construct validity was found.ConclusionWe recommend continued research and revisions to the ICU to better assess the presence of callous–unemotional traits in community samples of school‐age children.
Irreversible metronidazole encephalopathy in an elderly woman with primary biliary cholangitis
Authors: Onuma Yuki , Oki Masayuki , Komatsu Masamichi , Ishitani Sho , Kijima Kei , Fukuda Ryuki , Moriya Yusuke , Ozawa Hideki , Takagi Atsushi 
Published: June 2017

AbstractAn 82‐year‐old woman with primary biliary cholangitis was diagnosed with an irreversible neurological disorder, caused by metronidazole (MNZ)‐induced encephalopathy. Although the disorder is a reversible pathological condition, in rare cases, it can cause serious sequelae or could even be fatal. Therefore, medications should be administered carefully, particularly in patients who require long‐term administration of large doses or those with liver dysfunction.
How common are cranial sesamoids among squamates?
Authors: Montero Ricardo , Daza Juan D. , Bauer Aaron M. , Abdala Virginia 
Published: June 2017

AbstractSesamoids are elements that originate as intratendinous structures due to genetic and epigenetic factors. These elements have been reported frequently in vertebrates, although cranial sesamoids have been recorded almost exclusively in non‐tetrapod Osteichthyes. The only tetrapod cranial sesamoids reported until now have been the transiliens cartilage (of crocodiles and turtles), and another one located in the quadrate‐mandibular joint of birds. Here, we examined seven squamate species using histological sections, dissections of preserved specimens, dry skeletons, cleared and stained specimens, computed tomographies (CT), and report the presence of other cranial sesamoids. One is attached to the cephalic condyle of the quadrate, embedded in the bodenaponeurosis and jaw adductor muscles of Ophiodes intermedius (Anguidae). The other sesamoid is found at the base of the basicranium of several squamates, capping the sphenoccipital tubercle, on the lateral side of the basioccipital–basisphenoid suture. This bone has previously been reported as “element X.” We reinterpret it as a basicranial sesamoid, as it is associated with tendons of the cranio‐cervical muscles. This bone seems to have the function of resisting tension‐compression forces generated by the muscle during flexion the head. This element was previously known in several squamates, and we confirmed its presence in three additional squamate families: Gymnophthalmidae, Gekkonidae, and Pygopodidae. The evidence suggests that cranial sesamoids are a widespread character in squamates, and it is possible that this feature has been present since the origin of the group.
Capillary zone electrophorsis for the analysis of naturally occurring 2‐hydroxycitric acids and their lactones
Authors: Abhijith B. L. , Mohan Moolya , Joseph David , Haleema Simimole , Aboul‐Enein Hassan Y. , Ibnusaud Ibrahim 
Published: June 2017

A simple capillary zone electrophoresis method with direct ultraviolet detection has been developed for the analysis of naturally occurring diastereomeric 2‐hydroxycitric acid lactones. Using 50 mM sodium phosphate buffer of pH 7, a baseline resolution Rs > 3.0 was observed for all organic acids selected for the present study. This method was employed for the quantitative determination of title acids present in the plant sources namely Garcinia cambogia fruit rinds and Hibiscus sabdariffa calyx. Conversion of 2‐hydroxycitric acids to their lactones on heating the above plant sources is deliberated. The Hydrolysis of hydroxycitric acid lactones in aqueous solution is reported for the first time.
Time‐driven activity‐based costing to estimate cost of care at multidisciplinary aerodigestive centers
Authors: Garcia Jordan A. , Mistry Bipin , Hardy Stephen , Fracchia Mary Shannon , Hersh Cheryl , Wentland Carissa , Vadakekalam Joseph , Kaplan Robert , Hartnick Christopher J. 
Published: June 2017

Objectives/HypothesisProviding high‐value healthcare to patients is increasingly becoming an objective for providers including those at multidisciplinary aerodigestive centers. Measuring value has two components: 1) identify relevant health outcomes and 2) determine relevant treatment costs. Via their inherent structure, multidisciplinary care units consolidate care for complex patients. However, their potential impact on decreasing healthcare costs is less clear. The goal of this study was to estimate the potential cost savings of treating patients with laryngeal clefts at multidisciplinary aerodigestive centers.Study DesignRetrospective chart review.MethodsTime‐driven activity‐based costing was used to estimate the cost of care for patients with laryngeal cleft seen between 2008 and 2013 at the Massachusetts Eye and Ear Infirmary Pediatric Aerodigestive Center. Retrospective chart review was performed to identify clinic utilization by patients as well as patient diet outcomes after treatment. Patients were stratified into neurologically complex and neurologically noncomplex groups.ResultsThe cost of care for patients requiring surgical intervention was five and three times as expensive of the cost of care for patients not requiring surgery for neurologically noncomplex and complex patients, respectively. Following treatment, 50% and 55% of complex and noncomplex patients returned to normal diet, whereas 83% and 87% of patients experienced improved diets, respectively. Additionally, multidisciplinary team‐based care for children with laryngeal clefts potentially achieves 20% to 40% cost savings.ConclusionsThese findings demonstrate how time‐driven activity‐based costing can be used to estimate and compare patient costs in multidisciplinary aerodigestive centers.Level of Evidence2c. Laryngoscope, 127:2152–2158, 2017