bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental investigation and analysis on the wear properties of glass fiber and CNT reinforced hybrid polymer composites
Authors: Venkatesan M. , Palanikumar K. , Boopathy S. Rajendra 
Published: October 2017

Abstract
The aviation, automobile, and consumer products industry requires long-life, durable, lightweight high-performance polymer matrix composites. Polymer fiber reinforced materials possess low weight and high specific quality along with high specific stiffness. The addition of carbon nanoparticles in the composites improves their mechanical properties, including wear enhancement, which leads to the utilization of these composites in different fields. The present work investigates the wear performance of glass fiber and carbon nanotube (CNT) reinforced hybrid polymer composites. Dry sliding tests for wear were conducted using a pin-on-disc wear tester by varying the load and speed. The worn surfaces were examined by utilizing scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, and atomic force microscopy. The result shows that the increase in volume percentage of CNTs in glass fiber reinforced polymer composites decreases the wear rate. The result also clearly states that the coefficient of friction increases with an increase in the CNT percentage.
Effect of oxygen plasma treatment on tensile strength of date palm fibers and their interfacial adhesion with epoxy matrix
Authors: Gholami Maryam , Ahmadi Mohammad Saleh , Tavanaie Mohammad Ali , Khajeh Mehrizi Mohammad 
Published: October 2017

Abstract
In recent years, natural fibers have received much attention from various industrial applications. As these fibers are lightweight, nonabrasive, low cost, ecofriendly and biodegradable, they can be sometimes considered as alternatives to synthetic fibers in lightweight composite structures. In this work, date palm fibers (DPFs) were treated by oxygen plasma at various plasma discharge power and exposure time. The effects of plasma treatment on tensile strength of DPF and interfacial adhesion between DPF and epoxy were determined by single fiber tensile test and microbond test, respectively. Scanning electron microscopy was used to investigate the surface morphologies of DPFs before and after the plasma treatment. The functional groups on the surface were studied by attenuated total reflectance-Fourier transform infrared spectroscope (ATR-FTIR). Decrease in hemicellulose and lignin content of DPF was indicated in ATR-FTIR spectra of the treated sample with plasma treatment. The results show that plasma treatment cleans the fiber surface and increases the surface roughness by etching effect. Moreover, fiber surface modification significantly improves tensile properties of DPFs and interfacial shear stress (IFSS) of fiber/matrix. However, the effects of plasma power and exposure time on tensile properties and IFSS values of DPFs are not found significant. Moreover, Weibull statistics show that plasma treatment could not decrease the variability in fiber strength due to the nature of fibers.
Noradrenergic Regulation of Central Amygdala in Aversive Pavlovian-to-Instrumental Transfer
Authors: Campese Vincent D. , Soroeta Jose M. , Vazey Elena M. , Aston-Jones Gary , LeDoux Joseph E. , Sears Robert M. 
Published: October 2017

AbstractThe neural mechanisms through which a Pavlovian conditioned stimulus (CS) elicits innate defense responses are well understood. But a Pavlovian CS can also invigorate ongoing instrumental responding, as shown by studies of aversive Pavlovian-to-instrumental transfer (PIT). While the neural circuitry of appetitive PIT has been studied extensively, little is known about the brain mechanisms of aversive PIT. We recently showed the central amygdala (CeA) is essential for aversive PIT. In the current studies, using pharmacology and designer receptors in rodents, we demonstrate that noradrenergic (NE) activity negatively regulates PIT via brainstem locus coeruleus (LC) activity and LC projections to CeA. Our results provide evidence for a novel pathway through which response modulation occurs between brainstem neuromodulatory systems and CeA to invigorate adaptive behavior in the face of threat.
Protein Kinase A Deregulation in the Medial Prefrontal Cortex Impairs Working Memory in Murine Oligophrenin-1 Deficiency
Authors: Zhang Chun-Lei , Aime Mattia , Laheranne Emilie , Houbaert Xander , El Oussini Hajer , Martin Christelle , Lepleux Marilyn , Normand Elisabeth , Chelly Jamel , Herzog Etienne , Billuart Pierre , Humeau Yann 
Published: October 2017

Classical and systems genetics have identified wide networks of genes associated with cognitive and neurodevelopmental diseases. In parallel to deciphering the role of each of these genes in neuronal or synaptic function, evaluating the response of neuronal and molecular networks to gene loss of function could reveal some pathophysiological mechanisms potentially accessible to nongenetic therapies. Loss of function of the Rho-GAP oligophrenin-1 is associated with cognitive impairments in both human and mouse. Upregulation of both PKA and ROCK has been reported inOphn1−/ymice, but it remains unclear whether kinase hyperactivity contributes to the behavioral phenotypes. In this study, we thoroughly characterized a prominent perseveration phenotype displayed byOphn1-deficient mice using a Y-maze spatial working memory (SWM) test. We report thatOphn1deficiency in the mouse generated severe cognitive impairments, characterized by both a high occurrence of perseverative behaviors and a lack of deliberation during the SWM test.In vivoandin vitropharmacological experiments suggest that PKA dysregulation in the mPFC underlies cognitive dysfunction inOphn1-deficient mice, as assessed using a delayed spatial alternation task results. Functionally, mPFC neuronal networks appeared to be affected in a PKA-dependent manner, whereas hippocampal-PFC projections involved in SWM were not affected inOphn1−/ymice. Thus, we propose that discrete gene mutations in intellectual disability might generate “secondary” pathophysiological mechanisms, which are prone to become pharmacological targets for curative strategies in adult patients.SIGNIFICANCE STATEMENTHere we report thatOphn1deficiency generates severe impairments in performance at spatial working memory tests, characterized by a high occurrence of perseverative behaviors and a lack of decision making. This cognitive deficit is consecutive to PKA deregulation in the mPFC that preventsOphn1KO mice to exploit a correctly acquired rule. Functionally, mPFC neuronal networks appear to be affected in a PKA-dependent manner, whereas behaviorally important hippocampal projections were preserved by the mutation. Thus, we propose that discrete gene mutations in intellectual disability can generate “secondary” pathophysiological mechanisms prone to become pharmacological targets for curative strategies in adults.
Distinctive Modulation of Dopamine Release in the Nucleus Accumbens Shell Mediated by Dopamine and Acetylcholine Receptors
Authors: Shin Jung Hoon , Adrover Martin F. , Alvarez Veronica A. 
Published: October 2017

Nucleus accumbens (NAc) shell shows unique dopamine (DA) signalsin vivoand plays a unique role in DA-dependent behaviors such as reward-motivated learning and the response to drugs of abuse. A disynaptic mechanism for DA release was reported and shown to require synchronized firing of cholinergic interneurons (CINs) and activation of nicotinic acetylcholine (ACh) receptors (nAChRs) in DA neuron (DAN) axons. The properties of this disynaptic mechanism of DA transmission are not well understood in the NAc shell. In this study,in vitrofast-scan cyclic voltammetry was used to examine the modulation of DA transmission evoked by CINs firing in the shell of mice and compared with other striatal regions. We found that DA signals in the shell displayed significant degree of summation in response to train stimulation of CINs, contrary to core and dorsal striatum. The summation was amplified by a D2-like receptor antagonist and experiments with mice with targeted deletion of D2 receptors to DANs or CINs revealed that D2 receptors in CINs mediate a fast inhibition observed within 100 ms of the first pulse, whereas D2 autoreceptors in DAN terminals are engaged in a slower inhibition that peaks at ∼500 ms. ACh also contributes to the use-dependent inhibition of DA release through muscarinic receptors only in the shell, where higher activity of acetylcholinesterase minimizes nAChR desensitization and promotes summation. These findings show that DA signals are modulated differentially by endogenous DA and ACh in the shell, which may underlie the unique features of shell DA signalsin vivo.SIGNIFICANCE STATEMENTThe present study reports that dopamine (DA) release evoked by activation of cholinergic interneurons displays a high degree of summation in the shell and shows unique modulation by endogenous DA and acetylcholine. Desensitization of nicotinic receptors, which is a prevailing mechanism for use-dependent inhibition in the nucleus accumbens core and dorsal striatum, is also minimal in the shell in part due to elevated acetylcholinesterase activity. This distinctive modulation of DA transmission in the shell may have functional implications in the acquisition of reward-motivated behaviors and reward seeking.
Dissociation of Self-Motion and Object Motion by Linear Population Decoding That Approximates Marginalization
Authors: Sasaki Ryo , Angelaki Dora E. , DeAngelis Gregory C. 
Published: October 2017

We use visual image motion to judge the movement of objects, as well as our own movements through the environment. Generally, image motion components caused by object motion and self-motion are confounded in the retinal image. Thus, to estimate heading, the brain would ideally marginalize out the effects of object motion (or vice versa), but little is known about how this is accomplished neurally. Behavioral studies suggest that vestibular signals play a role in dissociating object motion and self-motion, and recent computational work suggests that a linear decoder can approximate marginalization by taking advantage of diverse multisensory representations. By measuring responses of MSTd neurons in two male rhesus monkeys and by applying a recently-developed method to approximate marginalization by linear population decoding, we tested the hypothesis that vestibular signals help to dissociate self-motion and object motion. We show that vestibular signals stabilize tuning for heading in neurons with congruent visual and vestibular heading preferences, whereas they stabilize tuning for object motion in neurons with discrepant preferences. Thus, vestibular signals enhance the separability of joint tuning for object motion and self-motion. We further show that a linear decoder, designed to approximate marginalization, allows the population to represent either self-motion or object motion with good accuracy. Decoder weights are broadly consistent with a readout strategy, suggested by recent computational work, in which responses are decoded according to the vestibular preferences of multisensory neurons. These results demonstrate, at both single neuron and population levels, that vestibular signals help to dissociate self-motion and object motion.SIGNIFICANCE STATEMENTThe brain often needs to estimate one property of a changing environment while ignoring others. This can be difficult because multiple properties of the environment may be confounded in sensory signals. The brain can solve this problem by marginalizing over irrelevant properties to estimate the property-of-interest. We explore this problem in the context of self-motion and object motion, which are inherently confounded in the retinal image. We examine how diversity in a population of multisensory neurons may be exploited to decode self-motion and object motion from the population activity of neurons in macaque area MSTd.
Membrane scission driven by the PROPPIN Atg18
Authors: Gopaldass Navin , Fauvet Bruno , Lashuel Hilal , Roux Aurélien , Mayer Andreas 
Published: October 2017

AbstractSorting, transport, and autophagic degradation of proteins in endosomes and lysosomes, as well as the division of these organelles, depend on scission of membrane‐bound tubulo‐vesicular carriers. How scission occurs is poorly understood, but family proteins bind these membranes. Here, we show that the yeast PROPPIN Atg18 carries membrane scission activity. Purified Atg18 drives tubulation and scission of giant unilamellar vesicles. Upon membrane contact, Atg18 folds its unstructured CD loop into an amphipathic α‐helix that inserts into the bilayer. This allows the protein to engage its two lipid binding sites for PI3P and PI(3,5)P2. PI(3,5)P2 induces Atg18 oligomerization, which should concentrate lipid‐inserted α‐helices in the outer membrane leaflet and drive membrane tubulation and scission. The scission activity of Atg18 is compatible with its known roles in endo‐lysosomal protein trafficking, autophagosome biogenesis, and vacuole fission. Key features required for membrane tubulation and scission by Atg18 are shared by other PROPPINs, suggesting that membrane scission may be a generic function of this protein family.
The Efficacy of Palifermin on Oral Mucositis and acute GVHD after Hematopoietic Stem Cell Transplantation in Hematologic Malignancy Patients: A Systematic Review and Meta-analysis study
Authors: Payandeh Mehrdad , Sadeghi Masoud , Ramezani Mazaher , Reza Mozaffari Hamid 
Published: October 2017

Oral mucositis (OM) is one of the most common side effects after hematopoietic stem cell transplantation (HSCT) and palifermin is used for prophylactic use to prevent OM. We conducted a meta-analysis study that evaluates the efficacy of palifermin on OM after HSCT in hematologic malignancy patients. Databases of PubMed/Medline, Web of Science and Cochrane Library for English-language publications were searched for finding the relevant studies. The RevMan 5.3 software with random-effects models (odds ratio (ORs) and 95% confidence intervals (CIs)) was used for to estimate of the efficacy of palifermin in palifermin group compared with control group. Begg's and Egger's tests were used for assessment of bias between the studies. Ten studies were included in the meta-analysis study. The results of the meta-analyses showed that there were significant differences in OM (grade 1-4) [odds ratio (OR) = 0.17; 95%CI= 0.10,0.29; p <0.00001], OM (grade 2-4) [OR= 0.11; 95%CI= 0.05,0.24; p <0.00001], OM (grade 3-4) [OR= 0.22; 95%CI= 0.15,0.33; p <0.00001], after auto-HSCT for OM (grade 1-4) [OR= 0.13; 95%CI= 0.04, 0.35; p <0.0001], OM (grade 2-4) [OR= 0.03; 95%CI= 0.00, 0.21; p =0.0006] or OM (grade 3-4) [OR= 0.25; 95%CI= 0.13, 0.48; p <0.0001], after allo-HSCT for OM (grade 1-4) [OR= 0.23; 95%CI= 0.11, 0.51; p =0.0002], OM (grade 2-4) [OR= 0.14; 95%CI= 0.03, 0.74; p =0.012] or OM (grade 3-4) [OR= 0.19; 95%CI= 0.08, 0.46; p =0.0002] and fever [OR=0.51; 95%CI=0.29, 0.87; p = 0.01], but there were no significant differences in acute graft versus host disease (aGVHD) grades, infection and blood stream infection between two groups. The meta-analysis showed that palifermin was associated with reductions in the incidence and severity of OM and also was effective and safe on OM after allo- or auto-HSCT, but did not seem to effect on the incidence and severity of aGVHD.

Peer Review Details

Peer review method: Single-Blind (Peer-reviewers: 02) Peer-review policy
Plagiarism software screening?: Yes
Date of Original Submission: 01 September 2017
Date accepted: 02 October 2017
Peer reviewers approved by: Dr. Lili Hami
Editor who approved publication: Dr. Phuc Van Pham
Pengembangan Aplikasi Sistem Pendukung Keputusan Berbasis Web Dalam Penentuan Pemenang Tender Menggunakan Metode Bayes dan Group Technology
Authors: Latif Lita Asyriati , Abbas Said Hi , Jamil Mohamad 
Published: October 2017

<p>Tujuan dilaksanakannya tender adalah untuk memberikan kesempatan yang sama kepada pelaku usaha agar dapat ikut menawarkan harga dan kualitas yang bersaing. Sehingga pada akhirnya dalam pelaksanaan proses tender tersebut akan didapatkan harga yang termurah dengan kualitas yang terbaik. Dalam proses pelelangan sampai dengan proses penetapan pemenang lelang sering menimbulkan permasalahan menggunakan cara serta tahapan konvensional, hal ini sangat tidak efektif melihat dari tahapan proses yang di lakukan sangat memakan waktu sehingga waktu terbuang sia-sia. Dengan adanya kelemahan proses pengadaan barang/jasa tersebut maka dalam penelitain ini akan dilakukan implementasi metode <em>bayes</em> dan <em>group technolgy </em>dalam sistem pendukun keputusan dalam penentuan pemenang tender proyek pemerintah </p>
Outcome analysis of vacuum assisted closure therapy in patients with open wounds
Authors: Jain Ravi Kant , Mohammad Danish , Mahajan Pranav , Sheikh Tanveer , Rege Awyay 
Published: October 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Vacuum assisted Closure (VAC) of wound is a recent trend and proven method of fast and better healing of wounds. The basic concept is the removal of blood and serous collection from the wound site with negative pressure and promoting the healing process rapidly by altering the local microcellular environment.</span><span lang="EN-IN">The objective of the study was to show the efficacy of healing process in open wounds treated by VAC method of dressing.</span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">In this prospective study, total of 50 patients with </span><span lang="EN-IN">upper and lower limbs non-healing open wounds were recruited. Before the application of VAC, surgical debridement was performed to remove all the devitalized necrotic tissues and the wound was packed with povodine iodine. Prior to and at the end of VAC dressing, wound dimensions were noted</span>.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Patients mean age was 46.72±7.63 years and out of which 42 patients (84%) were males and 8 patients (16%) were females. All patients had suffered an acute trauma. VAC therapy was applied through continuous or intermittent suction on wounds and dressing were changed every second or third day. After application of VAC therapy all wounds showed improvement, which were indicated by presence of healthy granulation tissue, absence of necrotic tissue and subsequent wound closure. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">VAC dressing in an open wound is an efficient and safe adjunct to treat severe infections and may be a good alternative to treat the open wounds in selected patients. Short time intervals between VAC changes and short course of therapy result in good patient acceptance. This method is recommended for all the types of non-healing wounds management.</span></p>
Revealing causal pathways to sustainable water service delivery using fsQCA
Authors: Gasparro Kate E. , Walters Jeffrey P. 
Published: October 2017

Abstract
This study aimed to build on theory and practice regarding the combinations of conditions that influence water service sustainability when external partners are involved. The study investigates 26 well projects that have been implemented in developing countries with the assistance of Engineers Without Borders-USA (EWB-USA). Using past literature on sustainable water service delivery in developing communities, emergent coding techniques with project documents, and surveys with EWB-USA team members, this study identifies a set of project conditions to conduct fuzzy-set Qualitative Comparative Analysis (fsQCA). Findings show that the presence of a water committee cannot alone account for project sustainability. Additional conditions, such as technology and construction processes, project governance, and community engagement practices must also be considered for project sustainability. The relationship between construction quality and financial sustainability is also discussed. Overall, the findings from this research contribute to sector theory and reveal distinct pathways towards sustainable water services. These findings informed recommendations for EWB-USA well project implementation and management, and demonstrate the utility of fsQCA as a tool to navigate the complexities of water service delivery by external partners and improve understanding to increase water service sustainability.
Design and operation of a rainwater for drinking (RFD) project in a rural area: case study at Cukhe Elementary School, Vietnam
Authors: Dao Anh Dzung , Nguyen Duc Canh , Han Moo Young 
Published: October 2017

Abstract
Since 2014, a well-designed rainwater for drinking (RFD) project has been successfully operating at Cukhe Elementary School, near Hanoi, Vietnam. During that time, daily rainfall data, water consumption, water quality and questionnaires to the community were prepared. Several concerns over the design and operation of RFD projects, such as lack of sufficient rainfall data, water quality concerns, and public acceptance, are identified and overcome. Modeled results from using observed daily rainfall data, and using a simplified method from insufficient monthly data, are compared. The simplified method using insufficient rainfall data is acceptable for design within the error range of 0–11%. Rainwater quality after the use of the point of use treatment device proved that a well-designed rainwater harvesting (RWH) system ensures safe drinking water, which complies with WHO and Vietnam drinking water quality standards (VDWQS) guidelines. The people of the community liked the RFD system because of the satisfactory water quality and the economic benefits of not needing to purchase bottled water. The success of the RFD project at the Cukhe Elementary School proved the potential of promoting rainwater as drinking water in rural areas in developing countries, where a safe drinking water supply is a challenge, and should be promoted as an important means to achieve Sustainable Development Goal 6.
Upaya Pengembangan Laboratorium Berbasis SKKNI Di Jurusan Perhotelan D3 Undiksha
Authors: Rahmawati Putu Indah , Widiastini Ni Made Ary , Andiani Nyoman Dini 
Published: October 2017

Penelitian ini bertujuan untuk mendukung pengembangan laboratorium yang berbasis SKKNI (Standar Kompetensi Kerja Nasional Indonesia) di Jurusan Perhotelan D3 Undiksha. Untuk mencapai tujuan tersebut, maka penelitian ini membahas faktor faktor serta upaya apa saja yang perlu dilakukan dalam melengkapi laboratorium Jurusan D3 Perhotelan Undiksha sebagai wujud dari implementasi kurikulum berbasis SKKNI. Penelitian ini menggunakan teknik analisis kebutuhan (need assessment). Penelitian ini menghasilkan produk capaian berupa: database peralatan praktek serta mata kuliah yang berdasarkan kurikulum berbasis SKKNI. Telah terdapat 4 ruang laboratorium untuk menunjang pembelajaran yaitu: Edutel sebagai tempat praktik housekeeping dan front office, Ganesha tours and travel sebagai tempat belajar reservasi tiket pesawat dan hotel, laboratorium komputer, ruang C1 sebagai tempat praktik memasak dan menyajikan makanan. Namun dalam penyelenggaraannya masih terdapat beberapa kendala terutama ketersediaan peralatan, perlengkapan dan bahan baku untuk praktik. Strategi jangka pendek dan jangka panjang telah disiapkan oleh pengelola jurusan untuk mencapai tujuan pendidikan vokasi yaitu terciptanya tenaga profesional di bidang perhotelan.