bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peri-implant health, clinical outcome and patient-centred outcomes of implant-supported overdentures in the mandible and the maxilla
Authors: Offord David , Mathieson Grant , Kingsford Nicola , Matthys Carine , Glibert Maarten , De Bruyn Hugo 
Published: September 2017

Abstract
Objectives/Aims:
The primary aim of this retrospective pilot study was to evaluate the clinical outcome of overdentures on four non-splinted maxillary implants compared to the mandible using locator attachments and secondly to assess patient's opinion of the treatment.

Materials and Methods:
The treatment protocol used here is summarised as a single-stage surgical approach followed by immediate loading (same day in 12 of 17 patients) of a removable prosthesis in the maxilla and mandible. Most of the implants were installed into fresh extraction sockets. Clinical outcomes were evaluated in 68 southern implants, straight (non co-axis) or angulated (co-axis) in 17 patients. Patients were examined by independent examiners at an average follow-up of 14.5 months after implant placement.

Results:
Outcomes measured were implant survival, bone loss, bleeding on probing, probing pocket depths and plaque score in addition to quality of life measured with OHIP-14 questionnaires. An overall implant survival of 100% was achieved. The mean marginal bone level (mm) over the entire cohort of 66 measured implants was (1.4 mm; range, 0–5.5). A significant difference (P=0.01) was found between bone level, from implant head to bone contact in the maxilla (M, 0.9 mm; s.d., 1.1; range, 0–4) and the mandible (M, 1.7; s.d., 1.0; range, 0–5.5). The marginal bone-to-implant head distance with the angulated co-axis implants was 1.9 mm (s.d., 1.5; range, 0–5.5) compared to non co-axis, mean 1.2 mm (s.d., 1.1; range, 0–4) (P=0.01). The OHIP-14 overall mean was 3.3 (out of a maximum of 56).

Conclusion:
The implant survival was 100% and the patients benefited from the overdenture treatment on four non-connected implants. The extremely low OHIP-14 indicated a very high level of patient satisfaction following treatment. The results of this study merit further long-term investigation to fully investigate the success of immediately loading implants in the maxilla as well as cost-benefit.
Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention
Authors: Hjorth M F , Roager H M , Larsen T M , Poulsen S K , Licht T R , Bahl M I , Zohar Y , Astrup A 
Published: September 2017

Abstract
On the basis of the abundance of specific bacterial genera, the human gut microbiota can be divided into two relatively stable groups that might have a role in personalized nutrition. We studied these simplified enterotypes as prognostic markers for successful body fat loss on two different diets. A total of 62 participants with increased waist circumference were randomly assigned to receive an ad libitum New Nordic Diet (NND) high in fiber/whole grain or an Average Danish Diet for 26 weeks. Participants were grouped into two discrete enterotypes by their relative abundance of Prevotella spp. divided by Bacteroides spp. (P/B ratio) obtained by quantitative PCR analysis. Modifications of dietary effects of pre-treatment P/B group were examined by linear mixed models. Among individuals with high P/B the NND resulted in a 3.15 kg (95% confidence interval (CI): 1.55; 4.76, P<0.001) larger body fat loss compared with ADD, whereas no differences was observed among individuals with low P/B (0.88 kg (95% CI: −0.61; 2.37, P=0.25)). Consequently, a 2.27 kg (95% CI: 0.09; 4.45, P=0.041) difference in responsiveness to the diets were found between the two groups. In summary, subjects with high P/B ratio appeared more susceptible to lose body fat on diets high in fiber and whole grain than subjects with a low P/B ratio.
Speech Recognition and Cognitive Skills in Bimodal Cochlear Implant Users
Authors: Hua Håkan , Johansson Björn , Magnusson Lennart , Lyxell Björn , Ellis Rachel J. 
Published: September 2017

Purpose
To examine the relation between speech recognition and cognitive skills in bimodal cochlear implant (CI) and hearing aid users.

Method

Seventeen bimodal CI users (28–74 years) were recruited to the study. Speech recognition tests were carried out in quiet and in noise. The cognitive tests employed included the Reading Span Test and the Trail Making Test (Daneman & Carpenter, 1980; Reitan, 1958, 1992), measuring working memory capacity and processing speed and executive functioning, respectively. Data were analyzed using paired-sample
t
tests, Pearson correlations, and partial correlations controlling for age.

Results
The results indicate that performance on some cognitive tests predicts speech recognition and that bimodal listening generates a significant improvement in speech in quiet compared to unilateral CI listening. However, the current results also suggest that bimodal listening requires different cognitive skills than does unimodal CI listening. This is likely to relate to the relative difficulty of having to integrate 2 different signals and then map the integrated signal to representations stored in the long-term memory.

Conclusions
Even though participants obtained speech recognition benefit from bimodal listening, the results suggest that processing bimodal stimuli involves different cognitive skills than does unimodal conditions in quiet. Thus, clinically, it is important to consider this when assessing treatment outcomes.
Observational calibration of the projection factor of Cepheids
Authors: Gallenne A. , Kervella P. , Mérand A. , Pietrzyński G. , Gieren W. , Nardetto N. , Trahin B. 
Published: September 2017

Context. The Baade-Wesselink (BW) method, which combines linear and angular diameter variations, is the most common method to determine the distances to pulsating stars. However, the projection factor, p-factor, used to convert radial velocities into pulsation velocities, is still poorly calibrated. This parameter is critical on the use of this technique, and often leads to 5–10% uncertainties on the derived distances.
Aims. We focus on empirically measuring the p-factor of a homogeneous sample of 29 LMC and 10 SMC Cepheids for which an accurate average distances were estimated from eclipsing binary systems.
Methods. We used the SPIPS algorithm, which is an implementation of the BW technique. Unlike other conventional methods, SPIPS combines all observables, i.e. radial velocities, multi-band photometry and interferometry into a consistent physical modelling to estimate the parameters of the stars. The large number and their redundancy insure its robustness and improves the statistical precision.
Results. We successfully estimated the p-factor of several Magellanic Cloud Cepheids. Combined with our previous Galactic results, we find the following P−p relation: −0.08± 0.04(log P−1.18) + 1.24± 0.02. We find no evidence of a metallicity dependent p-factor. We also derive a new calibration of the period-radius relation, log R = 0.684± 0.007(log P−0.517) + 1.489± 0.002, with an intrinsic dispersion of 0.020. We detect an infrared excess for all stars at 3.6 μm and 4.5 μm, which might be the signature of circumstellar dust. We measure a mean offset of Δm3.6 = 0.057 ± 0.006 mag and Δm4.5 = 0.065 ± 0.008 mag.
Conclusions. We provide a new P−p relation based on a multi-wavelength fit that can be used for the distance scale calibration from the BW method. The dispersion is due to the LMC and SMC width we took into account because individual Cepheids distances are unknown. The new P−R relation has a small intrinsic dispersion: 4.5% in radius. This precision will allow us to accurately apply the BW method to nearby galaxies. Finally, the infrared excesses we detect again raise the issue of using mid-IR wavelengths to derive period-luminosity relation and to calibrate the Hubble constant. These IR excesses might be the signature of circumstellar dust, and are never taken into account when applying the BW method at those wavelengths. Our measured offsets may give an average bias of ~ 2.8% on the distances derived through mid-IR P−L relations.
Reanimationspflichtige akute Eisenhutintoxikation in suizidaler Absicht
Authors: Stetzenbach Michael , Schnorbus Boris , Sagoschen Ingo , Bleser Werner , Legner Dominik , Stürer Andreas 
Published: September 2017

ZusammenfassungWir berichten über eine akute Eisenhutintoxikation einer 56-jährigen Patientin mit Blauem Eisenhut (Aconitum napellus) in suizidaler Absicht. Der Blaue Eisenhut gilt als die giftigste Pflanze Europas. Alle Pflanzenteile enthalten das hochgiftige Alkaloid Aconitin. Die letale Dosis beim Erwachsenen beträgt 2 – 6 mg. Intoxikationen verlaufen häufig tödlich. Auch asymptomatische Patienten mit Verdacht auf Eisenhutintoxikation sollten auf einer Intensivstation überwacht werden. Erste Intoxikationszeichen sind Parästhesien im Mund- und Rachenbereich, Bauchkrämpfe, Übelkeit, Erbrechen und starke Schmerzen der Skelettmuskulatur. Betroffene Patienten versterben innerhalb weniger Stunden nach Ingestion aufgrund von Atemlähmung und/oder Herzrhythmusstörungen.Die wichtigste Maßnahme nach oraler Ingestion besteht in einer möglichst schnellen primären Giftelimination (bei bewusstseinsklaren Patienten Erbrechen auslösen, sonst Magenspülung unter Schutzintubation) und der anschließenden Kohlegabe. Ein spezifisches Antidot steht nicht zur Verfügung. Das Management einer Intoxikation besteht vor allem aus der Therapie der Rhythmusstörungen in Form von Magnesium und Amiodaron.Auf die strikte Einhaltung von Eigenschutzmaßnahmen (Handschuhe, Mundschutz) muss unbedingt geachtet werden. Ein direkter Hautkontakt mit Pflanzenteilen ist ebenso zu vermeiden wie der potenzielle Kontakt mit Erbrochenem oder Aspirat.
A $C_p$ criterion for semiparametric causal inference
Authors: Baba Takamichi , Kanemori Takayuki , Ninomiya Yoshiyuki 
Published: September 2017

Summary
For marginal structural models, which play an important role in causal inference, we consider a model selection problem within a semiparametric framework using inverse-probability-weighted estimation or doubly robust estimation. In this framework, the modelling target is a potential outcome that may be missing, so there is no classical information criterion. We define a mean squared error for treating the potential outcome and derive an asymptotic unbiased estimator as a $C_{p}$ criterion using an ignorable treatment assignment condition. Simulation shows that the proposed criterion outperforms a conventional one by providing smaller squared errors and higher frequencies of selecting the true model in all the settings considered. Moreover, in a real-data analysis we found a clear difference between the two criteria.
Ecosystem change and decadal variation in stock–recruitment relationships of Lake Erie yellow perch (Perca flavescens)
Authors: Zhang Fan , Reid Kevin B , Nudds Thomas D 
Published: September 2017

AbstractFish stock–recruitment relationships (SRRs) may vary in response to ecosystem change, increasing uncertainty for fisheries management. We defined three periods between 1975 and 2015 over which Lake Erie, a Laurentian Great Lake, underwent significant ecosystem changes: before zebra mussel (Dreissena polymorpha) establishment, after zebra mussel establishment and before re-eutrophication, and after re-eutrophication. To examine the extent to which SRRs of Lake Erie yellow perch (Perca flavescens) also varied over these periods, we compared the performance of Baseline (constant recruitment), Ricker (constant SRR), Periodic Ricker (different SRRs among three periods) and Random-walk Ricker (annually varying SRRs) models fitted to data for yellow perch stocks corresponding to three lake basins. Periodic and Random-walk Ricker models performed better for stocks in the western and eastern basins, but the Baseline model performed best in the central basin. Annual variation in the SRRs coincided with the timing of zebra mussel establishment and re-eutrophication in the shallower western basin, but not in the deeper eastern basin, where quagga mussels (Dreissena bugensis) established later and conditions are less eutrophic. These results underscore that temporally and spatially varying SRRs associated with ecosystem change should be taken into account in models of fish population dynamics.
Deep Temporal Nerve Transfer for Facial Reanimation: Anatomic Dissections and Surgical Case Report
Authors: Mahan Mark A , Sivakumar Walavan , Weingarten David , Brown Justin M 
Published: September 2017

Abstract

BACKGROUND
Facial nerve palsy is a disabling condition that may arise from a variety of injuries or insults and may occur at any point along the nerve or its intracerebral origin.

OBJECTIVE
To examine the use of the deep temporal branches of the motor division of the trigeminal nerve for neural reconstruction of the temporal branches of the facial nerve for restoration of active blink and periorbital facial expression.

METHODS
Formalin-fixed human cadaver hemifaces were dissected to identify landmarks for the deep temporal branches and the tension-free coaptation lengths. This technique was then utilized in 1 patient with a history of facial palsy due to a brainstem cavernoma.

RESULTS
Sixteen hemifaces were dissected. The middle deep temporal nerve could be consistently identified on the deep side of the temporalis, within 9 to 12 mm posterior to the jugal point of the zygoma. From a lateral approach through the temporalis, the middle deep temporal nerve could be directly coapted to facial temporal branches in all specimens. Our patient has recovered active and independent upper facial muscle contraction, providing the first case report of a distinct distal nerve transfer for upper facial function.

CONCLUSION
The middle deep temporal branches can be readily identified and utilized for facial reanimation. This technique provided a successful reanimation of upper facial muscles with independent activation. Utilizing multiple sources for neurotization of the facial muscles, different potions of the face can be selectively reanimated to reduce the risk of synkinesis and improved control.
Heart Rate Variability as a Feeding Intervention Outcome Measure in the Preterm Infant
Authors: Pados Britt F. , Thoyre Suzanne M. , Knafl George J. , Nix William Brant 
Published: September 2017

Background:
Feeding interventions for preterm infants aim to reduce the physiologic stress of feeding to promote growth. Heart rate variability (HRV) is a potential noninvasive measure of physiologic stress that may be useful for evaluating efficacy of feeding interventions.

Purpose:
To evaluate whether HRV is a sensitive measure of physiologic stress compared with standard physiologic outcomes in the context of a feeding intervention study.

Methods:
This was a secondary analysis of a within-subjects, cross-over design study comparing usual care feeding with a gentle, coregulated (CoReg) feeding approach in 14 infants born less than 35 weeks' postmenstrual age. HRV indices were calculated from electrocardiogram data and compared with standard physiologic outcomes, including oxygen saturation (Spo2), respiratory rate (RR), apnea, heart rate (HR), and bradycardia. Data were analyzed using linear mixed modeling.

Results:
Infants fed using the CoReg approach had fewer apneic events and higher RR, suggesting they were able to breathe more during feeding. No statistically significant differences were found in Spo
2, HR, bradycardia, or high frequency power (the most commonly reported measure of HRV). Infants fed using the usual care approach had significantly higher SD12, a measure of HRV indicating randomness in the HR, which is a potential indicator of elevated stress.

Implications for Practice:
SD12 was more sensitive to stress than Spo
2, HR, and bradycardia. The utility of HRV as a measure of feeding outcomes in clinical practice needs further exploration.

Implications for Research:
Further exploration of HRV as an intervention outcome measure is needed, particularly evaluating nonlinear indices, such as SD12.
Proximal Screw Configuration Alters Peak Plate Strain Without Changing Construct Stiffness in Comminuted Supracondylar Femur Fractures
Authors: McLachlin Stewart , Kreder Hans , Ng Matthew , Jenkinson Richard , Whyne Cari , Larouche Jeremie 
Published: September 2017

Objectives:
Assess the effect of proximal screw configuration on the strain in lateral plating of a simulated comminuted supracondylar femur fracture.

Methods:
Fractures were simulated in 12 synthetic femurs by removing a 200-mm section of bone, located 60 mm from the intercondylar fossa and repaired using a 16-hole locked lateral plate instrumented with 8 uniaxial strain gauges. Three proximal screw type configurations were evaluated: (1) 4 nonlocking screws, (2) 4 locking screws, and (3) a hybrid configuration of 2 nonlocking screws flanked by a locking screw at each end of the proximal fragment. Each screw type was compared for 2 working lengths (∼90 and 160 mm). The longer working length was created by removing the proximal screw closest to the fracture gap. Testing consisted of a vertical load (500 N) applied to the head of femur. Configurations were compared using plate strain, construct stiffness, and fracture gap displacement as outcome measures.

Results:
Plate strain immediately above the fracture gap was reduced with nonlocking screws compared with the other screw types. Plate strains were reduced around the fracture gap with the longer working length but increased for the nonlocking construct at the location of the removed screw. Construct stiffness was not altered by screw type or working length. An increase in fracture gap displacement was only evident in shear translation with the longer working length.

Conclusions:
Plate strain in lateral plating of supracondylar femur fractures is decreased using nonlocking screws proximal to the fracture. Increasing the working length reduces plate strains over the working length yet should be cautioned because of increased interfragmentary shear motion.
Critical Care Resources in Guangdong Province of China: Three Surveys from 2005 to 2015*
Authors: Wu Jian-Feng , Pei Fei , Ouyang Bin , Chen Juan , Li Yi-Min , Feng Yong-Wen , Guo Fa-Liang , Zhou Li-Xin , Wang Zheng , Guo Ying-Jun , Lin Qin-Han , Li Zhan-Peng , Ling Yun , Li Li , Deng Lie-Hua , Zhao Ying-Ping , Dai Jian-Wei , Luo Shu-Yu , Zhou Dun-Rong , Luo Wei-Wen , Zhao Ling , Chen Wei-Ying , Wang Wei-Chuan , Cai Wen-Yang , Luo Qiong-Xiang , Guan Xiang-Dong 
Published: September 2017

Objectives:
Data about the critical care resources in China remain scarce. The purpose of this study was to investigate the variation and distribution of critical care resources in Guangdong province from 2005 to 2015.

Design:
Data in regard to critical care resources were collected through questionnaires and visits every 5 years from 2005.

Setting:
All hospitals in Guangdong province were screened and hospitals that provide critical care services were enrolled.

Intervention:
None.

Measurements and Main Results:
One hundred eleven, 158, and 284 hospitals that provide critical care services were enrolled in the three consecutive surveys respectively. The number of ICUs, ICU beds, intensivists, and nurses increased to 324, 3,956, 2,470, and 7,695, respectively, by 2015. Adjusted by population, the number of ICU beds per 100,000 (100,000) population increased by 147.7% from 2005 to 2015, and the number of intensivists and nurses per 100,000 population increased by 35.3% and 55.1% from 2011 to 2015. However, the numbers in the Pearl River Delta, a richer area, were higher than those in the non–Pearl River Delta area (ICU beds: 4.64 vs 2.58; intensivists: 2.90 vs 1.61; nurses: 9.30 vs 4.71 in 2015). In terms of staff training, only 17.85% of intensivists and 14.29% of nurses have completed a formal accredited critical care training program by 2015.

Conclusions:
Our study was the first one to investigate the trend and distribution of critical care resources in China. The quantity of ICU beds and staff has been increasing rapidly, but professional training for staff was inadequate. The distribution of critical care resources was unbalanced. Our study can be beneficial for healthcare policymaking and the allocation of critical care resources in Guangdong province and other provinces in China.
Anaplastic gliomas in adults: an update
Authors: Izquierdo Cristina , Joubert Bastien , Ducray François 
Published: September 2017

Purpose of review
The current review summarizes recent advances on the oncogenesis, classification and treatment of adult anaplastic gliomas.

Recent findings
According to the 2016 WHO classification, three main molecular subgroups of adult diffuse anaplastic gliomas can be distinguished based on the 1p/19q codeletion and isocitrate dehydrogenase (IDH) mutation status. In the future, this classification may be further refined based on the telomerase reverse transcriptase promoter and alpha thalassemia/mental retardation syndrome X-linked mutation status, gene expression, DNA methylation and genomic profiling. Both newly diagnosed 1p/19q codeleted and 1p/19q-intact anaplastic gliomas benefit from the addition of chemotherapy to radiotherapy. However, in 1p/19q codeleted anaplastic gliomas, Procarbazine, CCNU and Vincristine chemotherapy seems more effective than temozolomide. At recurrence, 1p/19q-intact anaplastic gliomas do not benefit from the addition of bevacizumab to temozolomide. The use of poly(adenosine 5′-diphosphate-ribose) inhibitors may be another way of specifically targeting IDH-mutant gliomas in addition to specific inhibitors, demethylating agents and anti-IDH vaccines. v-raf murine sarcoma viral oncogene homolog B1 (BRAF)-mutant anaplastic xanthoastrocytomas and gangliogliomas may benefit from BRAF and mitogen-activated protein kinase inhibitors.

Summary
Molecular characterization is mandatory for integrated diagnosis and appropriate management of adult anaplastic gliomas. Both 1p/19q codeleted and 1p/19q-intact anaplastic diffuse gliomas benefit from early chemotherapy. At recurrence, preliminary data suggest a potential role for targeted therapies in specific molecular subgroups.
Ethical Issues with Genetic Testing for Tay-Sachs
Authors: Clayton Tricia 
Published: September 2017

ABSTRACT:
Several genetic disorders are specific to Jewish heritage; one of the most devastating is Tay-Sachs disease.Tay-Sachs is a fatal hereditary disease, causing progressive neurological problems for which there is no cure. Ethical issues surrounding genetic testing for Tay-Sachs within the Jewish community continue to be complex and multifaceted. A perspective of Tay-Sachs, using rights-based ethics and virtue ethics as a theoretical framework, is explored.
Student Perspective Improves Spiritual Care Curriculum
Authors: Kroning Maureen , Yoon Deborah 
Published: September 2017

ABSTRACT:
Spiritual nursing care is a fundamental aspect of care often unobserved during students' clinical experiences. A nursing student shares her disillusionment about the lack of spiritual care she observed during a clinical rotation. Her instructor used the negative experience to identify areas for curriculum improvement to develop and address the lack of spiritual nursing care education.