bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why do batteries fail?
Authors: Palacín M. R. , de Guibert A. 
Published: February 2016

Why batteries go bad
Rechargeable batteries are found in a range of everyday devices, from shavers and laptops to cars and airplanes. Over time, these batteries can fail, either through a gradual loss of charge or through the inability to work under tough environmental conditions, leading to more catastrophic failures that cause fires or explosions. Palacin and de Guibert review such failures and suggest that, although often chemistry-specific, common causes can be found. They also look at ways to enhance battery lifetime, such as through improved battery management systems, which are needed for advanced rechargeable batteries.

Science
, this issue p.
10.1126/science.1253292
Draft Genome Sequence of a Pseudomonas aeruginosa Strain Able To Decompose
N
,
N
-Dimethyl Formamide
Authors: Yan Lingyue , Yan Ming , Xu Lin , Wei Li , Zhang Liting 
Published: February 2016

ABSTRACT

Pseudomonas aeruginosa
is a Gram-negative bacterium, which uses a variety of organic chemicals as carbon sources. Here, we report the genome sequence of the Cu1510 isolate from wastewater containing a high concentration of
N
,
N
-dimethyl formamide.
Genome Sequence of Acidovorax avenae Strain T10_61 Associated with Sugarcane Red Stripe in Argentina
Authors: Fontana Paola D. , Fontana Cecilia A. , Bassi Daniela , Puglisi Edoardo , Salazar Sergio M. , Vignolo Graciela M. , Coccocelli Pier S. 
Published: February 2016

ABSTRACT

Red stripe of sugarcane in Argentina is a bacterial disease caused by
Acidovorax avenae
. The genome sequence from the first isolate of this bacterium in Argentina is presented here. The draft genome of the
A. avenae
T10_61 strain contains 5,646,552 bp and has a G+C content of 68.6 mol%.
Draft Genome Sequence of Bacillus humi LMG 22167
T
(DSM 16318), an Endospore-Forming Bacterium Isolated from Soil
Authors: Wang Jie-ping , Liu Bo , Liu Guo-hong , Pan Zhizhen , Xiao Rong-feng , Chen Meichun , Chen De-ju 
Published: February 2016

ABSTRACT

Bacillus humi
LMG 22167
T
is a Gram-positive, aerobic, and spore-forming bacterium Here, we report the 4.80-Mb draft genome sequence of
B. humi
LMG 22167
T
, which is the first genome sequence of this species and will promote its fundamental research.
HandiVIH—A population-based survey to understand the vulnerability of people with disabilities to HIV and other sexual and reproductive health problems in Cameroon: protocol and methodological considerations
Authors: De Beaudrap Pierre , Pasquier Estelle , Tchoumkeu Alice , Touko Adonis , Essomba Frida , Brus Aude , Desgrées du Loû Annabel , Aderemi Toyin Janet , Hanass-Hancock Jill , Eide Arne Henning , Mont Daniel , Mac-Seing Muriel , Beninguisse Gervais 
Published: February 2016

IntroductionIn resource-limited countries, people with disabilities seem to be particularly vulnerable to HIV infection due to barriers to accessing information and services, frequent exposure to sexual violence and social exclusion. However, they have often been left behind in the HIV response, probably because of the lack of reliable epidemiological data measuring this vulnerability. Multiple challenges in conducting good quality epidemiological surveys on people with disabilities require innovative methods to better understand the link between disability and HIV. This paper describes how the design and methods of the HandiVIH study were adapted to document the vulnerability of people with disabilities to HIV, and to compare their situation with that of people without disabilities.Methods and analysisThe HandiVIH project aims to combine quantitative and qualitative data. The quantitative component is a cross-sectional survey with a control group conducted in Yaoundé (Cameroon). A two-phase random sampling is used (1) to screen people with disabilities from the general population using the Washington Group questionnaire and, (2) to create a matched control group. An HIV test is proposed to each study participant. Additionally, a questionnaire including a life-event interview is used to collect data on respondents’ life-course history of social isolation, employment, sexual partnership, HIV risk factors and fertility. Before the cross-sectional survey, a qualitative exploratory study was implemented to identify challenges in conducting the survey and possible solutions. Information on people with disabilities begging in the streets and members of disabled people's organisations is collected separately.Ethics and disseminationThis study has been approved by the two ethical committees. Special attention has been paid on how to adapt the consenting process to persons with intellectual disabilities. The methodological considerations discussed in this paper may contribute to the development of good practices for conducting quantitative health surveys on people with disabilities.Trial registration numberNCT02192658.
Surgical trainee research collaboratives in the UK: an observational study of research activity and publication productivity
Authors: Jamjoom Aimun A B , Phan Pho N H , Hutchinson Peter J , Kolias Angelos G 
Published: February 2016

ObjectivesTo analyse the research activity and publication output of surgical trainee research collaboratives in the UK.SettingSurgical trainee research collaboratives in the UK.ParticipantsA total of 24 collaboratives were included in this study from 33 identified organisations. We excluded one group that focused purely on systematic review of the literature and eight groups for which we could not identify suitable data sources (website or trainee committee contact).Primary and secondary outcomePrimary data-points were identified for each collaborative including surgical subspeciality, numbers and types of projects. For published articles, secondary outcomes including study population size, journal impact factor, number of citations and evidence level were collected.ResultsA total of 24 collaboratives met our inclusion criteria with a portfolio of 80 projects. The project types included audit (46%), randomised clinical trial (16%), surveys (16%), cohort studies (10%), systematic reviews (2.5%) and other or unidentifiable (9.5%). A total of 35 publications were identified of which just over half (54%) were original research articles. The median size of studied population was 540 patients with a range from 108 to 3138. The published works provided a varied compilation of evidence levels ranging from 1b (individual RCT) to 5 (expert opinion) with a median level of 2b (individual cohort study). The West Midlands Research Collaborative had the highest number of publications (13), citations (130) and h-index (5).ConclusionsThe experience of UK-based trainee research collaboratives provides useful insights for trainees and policymakers in global healthcare systems on the value and feasibility of trainee-driven high quality surgical research.
Yang–Mills gauge theory and the Higgs boson family
Authors: Chang Ngee-Pong 
Published: February 2016

The gauge symmetry principles of the Yang–Mills field of 1954 provide the solid rock foundation for the Standard Model of particle physics. To give masses to the quarks and leptons, however, SM calls on the solitary Higgs field using a set of mysterious complex Yukawa coupling matrices. We enrich the SM by reducing the Yukawa coupling matrices to a single Yukawa coupling constant, and endowing it with a family of Higgs fields that are degenerate in mass. The recent experimental discovery of the Higgs resonance at 125.09 ± 0.21 GeV does not preclude this possibility. Instead, it presents an opportunity to explore the interference effects in background events at the LHC. We present a study based on the maximally symmetric Higgs potential in a leading hierarchy scenario.
The Breast–Thyroid Cancer Link: A Systematic Review and Meta-analysis
Authors: Nielsen Sarah M. , White Michael G. , Hong Susan , Aschebrook-Kilfoy Briseis , Kaplan Edwin L. , Angelos Peter , Kulkarni Swati A. , Olopade Olufunmilayo I. , Grogan Raymon H. 
Published: February 2016

Abstract
Rates of thyroid cancer in women with a history of breast cancer are higher than expected. Similarly, rates of breast cancer in those with a history of thyroid cancer are increased. Explanations for these associations include detection bias, shared hormonal risk factors, treatment effect, and genetic susceptibility. With increasing numbers of breast and thyroid cancer survivors, clinicians should be particularly cognizant of this association. Here, we perform a systematic review and meta-analysis of the literature utilizing PubMed and Scopus search engines to identify all publications studying the incidence of breast cancer as a secondary malignancy following a diagnosis of thyroid cancer or thyroid cancer following a diagnosis of breast cancer. This demonstrated an increased risk of thyroid cancer as a secondary malignancy following breast cancer [OR = 1.55; 95% confidence interval (CI), 1.44–1.67] and an increased risk of breast cancer as a secondary malignancy following thyroid cancer (OR = 1.18; 95% CI, 1.09–1.26). There is a clear increase in the odds of developing either thyroid or breast cancer as a secondary malignancy after diagnosis with the other. Here, we review this association and current hypothesis as to the cause of this correlation. Cancer Epidemiol Biomarkers Prev; 25(2); 231–8. ©2016 AACR.
Notch1 Signaling Regulates the Aggressiveness of Differentiated Thyroid Cancer and Inhibits SERPINE1 Expression
Authors: Yu Xiao-Min , Jaskula-Sztul Renata , Georgen Maria R. , Aburjania Zviadi , Somnay Yash R. , Leverson Glen , Sippel Rebecca S. , Lloyd Ricardo V. , Johnson Brian P. , Chen Herbert 
Published: February 2016

Abstract
Purpose: Notch1, a transmembrane receptor, has been recently shown to aid in the determination of thyroid cell fate associated with tumorigenesis. This study aimed to investigate the clinical relevance of Notch1 and its role in the regulation of differentiated thyroid cancer (DTC) behavior.
Experimental Design: We examined Notch1 expression level and its relationship with clinicopathologic features and outcomes of DTC. Notch1 intracellular domain (NICD) was further characterized both in vitro and in vivo by gain-of-function assays using an inducible system.
Results: Notch1 expression levels were downregulated in primary DTC tissue samples compared with contralateral nontumor and benign thyroid tissues. Decreased Notch1 expression in DTC was associated with advanced patient age (P = 0.032) and the presence of extrathyroidal invasion (P = 0.005). Patients with lower Notch1 expression had a significantly higher recurrence rate (P = 0.038). Restoration of NICD in a stably doxycycline-inducible metastatic DTC cell line reduced cell growth and migration profoundly. Using an orthotopic thyroid cancer model, NICD induction significantly reduced the growth of the primary thyroid tumor and inhibited the development of lung metastasis. Serpin peptidase inhibitor, clade E, member 1 (SERPINE1) was discovered by microarray as the most significant gene downregulated by NICD. Further validation showed that the induction of NICD reduced SERPINE1 expression in a dose-dependent manner, whereas restoration of a relative higher level of SERPINE1 was observed with NICD back to minimal level. In addition, SERPINE1 knock-down inhibited DTC cell migration.
Conclusions: Notch1 regulates the aggressive phenotypes of DTC, which could be mediated by SERPINE1 inhibition. Notch1/SERPINE1 axis warrants further investigation as a novel therapeutic target for advanced DTC. Clin Cancer Res; 22(14); 3582–92. ©2016 AACR.
Impact of Genes Highly Correlated with MMSET Myeloma on the Survival of Non-MMSET Myeloma Patients
Authors: Wu S. Peter , Pfeiffer Ruth M. , Ahn Inhye E. , Mailankody Sham , Sonneveld Pieter , van Duin Mark , Munshi Nikhil C. , Walker Brian A. , Morgan Gareth , Landgren Ola 
Published: February 2016

Abstract
Purpose: The poor prognosis of multiple myeloma with t(4;14) is driven by the fusion of genes encoding multiple myeloma SET domain (MMSET) and immunoglobulin heavy chain. Specific genes affected by MMSET and their clinical implications in non-MMSET myeloma remain undetermined.
Experimental Design: We obtained gene expression profiles of 1,032 newly diagnosed myeloma patients enrolled in Total Therapy 2, Total Therapy 3, Myeloma IX, and HOVON65-GMMGHD4 trials and 156 patients from Multiple Myeloma Resource Collection. Probes that correlated most with MMSET myeloma were selected on the basis of a multivariable linear regression and Bonferroni correction and refined on the basis of the strength of association with survival in non-MMSET patients.
Results: Ten MMSET-like probes were associated with poor survival in non-MMSET myeloma. Non-MMSET myeloma patients in the highest quartile of the 10-gene signature (MMSET-like myeloma) had 5-year overall survival similar to that of MMSET myeloma [highest quartile vs. lowest quartile HR = 2.0; 95% confidence interval (CI), 1.5–2.8 in MMSET-like myeloma; HR = 2.3; 95% CI, 1.6–3.3 in MMSET myeloma]. Analyses of MMSET-like gene signature suggested the involvement of p53 and MYC pathways.
Conclusions: MMSET-like gene signature captures a subset of high-risk myeloma patients underrepresented by conventional risk stratification platforms and defines a distinct biologic subtype. Clin Cancer Res; 22(16); 4039–44. ©2016 AACR.
Adenoid Cystic Carcinoma Can Be Driven by MYB or MYBL1 Rearrangements: New Insights into MYB and Tumor Biology
Authors: Gonda Thomas J. , Ramsay Robert G. 
Published: February 2016

Abstract
Summary: A majority of adenoid cystic carcinomas (AdCC)—rare tumors of the salivary gland and some other organs—have recently been found to be driven by chromosomal translocations resulting in MYB–NFIB fusions. Brayer and colleagues and Mitani and colleagues have now reported that AdCCs can alternatively be driven by similar rearrangements involving a second MYB family gene, MYBL1, and that these two drivers act in remarkably similar ways. Cancer Discov; 6(2); 125–7. ©2016 AACR.
See related article by Brayer et al., p. 176.
Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis
Authors: Rahtu-Korpela Lea , Määttä Jenni , Dimova Elitsa Y. , Hörkkö Sohvi , Gylling Helena , Walkinshaw Gail , Hakkola Jukka , Kivirikko Kari I. , Myllyharju Johanna , Serpi Raisa , Koivunen Peppi 
Published: February 2016

Objective—
Small-molecule hypoxia-inducible factor prolyl 4-hydroxylase (HIF-P4H) inhibitors are being explored in clinical studies for the treatment of anemia. HIF-P4H-2 (also known as PHD2 or EglN1) inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction. We studied here whether HIF-P4H-2 inhibition could also protect against atherosclerosis.

Approach and Results—
Atherosclerosis development was studied in low-density lipoprotein (LDL) receptor–deficient mice treated with an oral HIF-P4H inhibitor, FG-4497, and in HIF-P4H-2-hypomorphic/C699Y-LDL receptor–mutant mice, all mice being fed a high-fat diet. FG-4497 administration to LDL receptor–deficient mice reduced the area of atherosclerotic plaques by ≈50% when compared with vehicle-treated controls and also reduced their weight gain, insulin resistance, liver and white adipose tissue (WAT) weights, adipocyte size, number of inflammation-associated WAT macrophage aggregates and the high-fat diet–induced increases in serum cholesterol levels. The levels of atherosclerosis-protecting circulating autoantibodies against copper-oxidized LDL were increased. The decrease in atherosclerotic plaque areas correlated with the reductions in weight, serum cholesterol levels, and WAT macrophage aggregates and the autoantibody increase. FG-4497 treatment stabilized HIF-1α and HIF-2α and altered the expression of glucose and lipid metabolism and inflammation-associated genes in liver and WAT. The HIF-P4H-2-hypomorphic/C699Y-LDL receptor–mutant mice likewise had a ≈50% reduction in atherosclerotic plaque areas, reduced WAT macrophage aggregate numbers, and increased autoantibodies against oxidized LDL, but did not have reduced serum cholesterol levels.

Conclusions—
HIF-P4H-2 inhibition may be a novel strategy for protecting against the development of atherosclerosis. The mechanisms involve beneficial modulation of the serum lipid profile and innate immune system and reduced inflammation.
Nonpsychotic Mental Disorders in Teenage Males and Risk of Early Stroke
Authors: Åberg Maria A.I. , Torén Kjell , Nilsson Michael , Henriksson Malin , Kuhn H. Georg , Nyberg Jenny , Rosengren Annika , Åberg N. David , Waern Margda 
Published: February 2016

Background and Purpose—
Although the incidence of stroke is on the decline worldwide, this is not the case for early stroke. We aimed to determine whether nonpsychotic mental disorder at the age of 18 years is a risk factor for early stroke, and if adolescent cardiovascular fitness and intelligence quotient might attenuate the risk.

Method—
Population-based Swedish cohort study of conscripts (n=1 163 845) who enlisted during 1968 to 2005. At conscription, 45 064 males were diagnosed with nonpsychotic mental disorder. Risk of stroke during follow-up (5–42 years) was calculated with Cox proportional hazards models. Objective baseline measures of fitness and cognition were included in the models in a second set of analyses.

Results—
There were 7770 first-time stroke events. In adjusted models, increased risk for stroke was observed in men diagnosed with depressive/neurotic disorders (hazard ratio [HR], 1.23; 95% confidence interval [CI], 1.11–1.37), personality disorders (HR, 1.52; 95% CI, 1.29–1.78), and alcohol/substance use disorders (HR, 1.61; 95% CI, 1.41–1.83) at conscription. Corresponding figures for fatal stroke were HR, 1.38; 95% CI, 1.06 to 1.79; HR, 2.26; 95% CI, 1.60 to 3.19; and HR, 2.20; 95% CI, 1.63 to 2.96. HRs for stroke were attenuated when fitness level and intelligence quotient were introduced. Associations remained significant for personality disorders and alcohol/substance use in the fully adjusted models. The interaction term was statistically significant for fitness but not for intelligence quotient.

Conclusions—
Our findings suggest that fitness may modify associations between nonpsychotic disorders and stroke. It remains to be clarified whether interventions designed to improve fitness in mentally ill youth can influence future risk of early stroke.
Simulating Climate Change Impacts and Adaptive Measures for Rice Cultivation in Hunan Province, China
Authors: Li Yamei , Wu Wenxiang , Ge Quansheng , Zhou Yang , Xu Chenchen 
Published: February 2016

AbstractClimate change will inevitably continue for the next few decades and will have an impact on climate-sensitive agricultural production, emphasizing the need to design effective adaptive strategies to cope with climate risk or take advantage of potential climatic benefits. In this study, the latest version of the Crop Environment Resource Synthesis-Rice (CERES-Rice) model was applied to assess the impacts of climate change and carbon dioxide (CO2) fertilization on rice yield, as well as the effectiveness of two popularly adopted adaptive measures in Hunan Province, the main rice-production location in China. The simulation spanned 30 years of baseline (1981–2010) as well as three future periods (2011–40, 2041–70, and 2071–99) with climate data generated by five general circulation models under the newly developed representative concentration pathway (RCP) 4.5 and 8.5 scenarios. The simulation results showed that, in comparison with average rice yield during the baseline (1981–2010), the ensemble-average yield of all cultivars during the 2020s, 2050s, and 2080s would decrease under both RCPs without CO2 fertilization effects. The ensemble-average yield reduction during the 2080s was alleviated under both RCPs if CO2 fertilization effects were accounted for. Adaptation simulations indicated that two adaptive measures (switching cultivars and changing planting dates) could mitigate the adverse effect to different extents. The intermodel variability under both RCPs was generally small. These findings may provide useful insight into the potential impacts of climate change on rice yield and effective adaptive measures to mitigate the adverse effect of future climate change in Hunan Province.
Chronic fatigue syndrome: Comparing outcomes in White British and Black and minority ethnic patients after cognitive–behavioural therapy
Authors: Ingman Tom , Ali Sheila , Bhui Kamaldeep , Chalder Trudie 
Published: February 2016

BackgroundCognitive–behavioural therapy (CBT) is one of the most promising treatments for chronic fatigue syndrome (CFS). It is unclear whether CBT is effective for Black and minority ethnic (BME) groups.AimsTo assess the effectiveness of CBT in BME patients compared with White British patients presenting to a specialist CFS service.MethodData from 67 (19.0%) BME participants and 285 (81.0%) White British participants referred to a specialist CFS service in the UK were collected at baseline and after CBT treatment.ResultsPairwise comparisons revealed that both BME participants and White British participants significantly improved on measures of fatigue severity (P<0.001), physical functioning (P<0.001) and work/social adjustment (P<0.001). Independent samples t-tests showed that BME participants improved despite exhibiting significantly higher baseline damage beliefs (P = 0.009), catastrophising (P = 0.024), all-or-nothing behaviour (P = 0.036) and avoidance/resting behaviour (P = 0.001), compared with White British participants.ConclusionsTo our knowledge, this study is the first to indicate that CBT is effective for treating CFS in a group of patients from diverse BME backgrounds.
Program Approach in Energy Sector’s Technological Platforms Development (by the Example of &#34; Russian Intellectual Power System&#34; Technological Platform)
Authors: Яковлева  , Yakovleva Anna , Яремчук  , Yaremchuk R. 
Published: February 2016

The analysis of features related to implementation of &#34;Intellectual Power
System of Russia&#34; technological platform development program is
presented in this paper. Possibilities for adaptation of program approach
for technological platform development have been investigated. Specific
conditions of context and relationship inside the program have been
considered. Recommendations on program implementation directions have
been offered.