bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Viologen Derivative Based Uranyl Coordination Polymers Featuring Photochromic Behaviors
Authors: Hu Kong‐Qiu , Wu Qun‐Yan , Mei Lei , Zhang Xiao‐Lin , Ma Lei , Song Gang , Chen Di‐Yun , Wang Yi‐Tong , Chai Zhi‐Fang , Shi Wei‐Qun 
Published: November 2017

AbstractA series of novel uranyl coordination polymers have been synthesized by hydrothermal reactions. Both complexes 1 and 2 prosess two ipbp− ligands (H2ipbpCl=1‐(3,5‐dicarboxyphenyl)‐4,4′‐bipyridinium chloride), one uranyl cation, and two coordination water molecules, which can further extend to 2D networks through hydrogen bonding. In complex 1, two sets of equivalent nets are entangled together, resulting in a 2D + 2D → 3D polycatenated framework. In complex 2, the neighbouring equivalent nets interpenetrate each other, forming a twofold interpenetrated network. Complexes 3 and 4 are isomers, and both of them are constructed from (UO2)2(OH)2 dinuclear units, which are connected with four ipbp− ligands. The 3D structures of complexes 3 and 4 are similar along the b axis. Similar to other viologen‐based coordination polymers, complexes 3 and 4 exhibit photochromic and thermochromic properties, which are rarely observed in actinide coordination polymers. Unlike the monotonous coordination mode in complexes 1–4, the ipbp− ligands feature a μ3‐bridge through two kinds of coordination modes in complex 5. Notably, complex 5 presents a unique example in which terminal pyridine nitrogen atom is involved in the coordination.
Rapid Iododeboronation with and without Gold Catalysis: Application to Radiolabelling of Arenes
Authors: Webster Stacey , O'Rourke Kerry M. , Fletcher Conor , Pimlott Sally L. , Sutherland Andrew , Lee Ai‐Lan 
Published: November 2017

AbstractRadiopharmaceuticals that incorporate radioactive iodine in combination with single‐photon emission computed tomography imaging play a key role in nuclear medicine, with applications in drug development and disease diagnosis. Despite this importance, there are relatively few general methods for the incorporation of radioiodine into small molecules. This work reports a rapid air‐ and moisture‐stable ipso‐iododeboronation procedure that uses NIS in the non‐toxic, green solvent dimethyl carbonate. The fast reaction and mild conditions of the gold‐catalysed method led to the development of a highly efficient process for the radiolabelling of arenes, which constitutes the first example of an application of homogenous gold catalysis to selective radiosynthesis. This was exemplified by the efficient synthesis of radiolabelled meta‐[125I]iodobenzylguanidine, a radiopharmaceutical that is used for the imaging and therapy of human norepinephrine transporter‐expressing tumours.
Adsorptive Purification of Ionic Liquids and their Reuse in Cellulose Processing
Authors: Watts Marcus , Kosan Birgit , Hammerschmidt Jochen , Dorn Susann , Meister Frank , Scholl Stephan 
Published: November 2017

AbstractUnfortunately, imidazole‐based ionic liquids (ILs) tend to build high‐boiling impurities like chromophores. This results in reduced process stability and product conditions like stained cellulose fibers. Therefore, different adsorbent materials were tested for their capability to purify the IL 1‐ethyl‐3‐methylimidazolium acetate. The product quality was monitored by UV‐vis spectroscopy. It was observed that activated carbon showed the best purification results. The purified IL was successfully reused in the process of cellulose dissolution and shaping.
Cross‐Classified Multilevel Modelling of the Effectiveness of Similarity‐Based Virtual Screening
Authors: Mazalan Lucyantie , Bell Andrew , Sbaffi Laura , Willett Peter 
Published: November 2017

AbstractThe screening effectiveness of a chemical similarity search depends on a range of factors, including the bioactivity of interest, the types of similarity coefficient and fingerprint that comprise the similarity measure, and the nature of the reference structure that is being searched against a database. This study introduces the use of cross‐classified multilevel modelling as a way to investigate the relative importance of these four factors when carrying out similarity searches on the ChEMBL database. Two principal conclusions can be drawn from the analyses: that the fingerprint plays a more important role than the similarity coefficient in determining the effectiveness of a similarity search, and that comparative studies of similarity measures should involve many more reference structures than has been the case in much previous work.
Five‐year relative survival for human papillomavirus‐associated cancer sites
Authors: Razzaghi Hilda , Saraiya Mona , Thompson Trevor D. , Henley S. Jane , Viens Laura , Wilson Reda 
Published: November 2017

BACKGROUNDHuman papillomavirus (HPV) vaccines can potentially prevent greater than 90% of cervical and anal cancers as well as a substantial proportion of vulvar, vaginal, penile, and oropharyngeal cancers caused by certain HPV types. Because more than 38,000 HPV‐associated cancers are diagnosed annually in the United States, current studies are needed to understand how relative survival varies for each of these cancers by certain demographic characteristics, such as race and age.METHODSThe authors examined high‐quality data from 27 population‐based cancer registries covering approximately 59% of the US population. The analyses were limited to invasive cancers that were diagnosed during 2001 through 2011 and followed through 2011 and met specified histologic criteria for HPV‐associated cancers. Five‐year relative survival was calculated from diagnosis until death for these cancers by age, race, and sex.RESULTSThe 5‐year age‐standardized relative survival rate was 64.2% for cervical carcinomas, 52.8% for vaginal squamous cell carcinomas (SCCs), 66% for vulvar SCCs, 47.4% for penile SCCs, 65.9% for anal SCCs, 56.2% for rectal SCCs, and 51.2% for oropharyngeal SCCs. Five‐year relative survival was consistently higher among white patients compared with black patients for all HPV‐associated cancers across all age groups; the greatest differences by race were observed for oropharyngeal SCCs among those aged <60 years and for penile SCCs among those ages 40 to 49 years compared with other age groups.CONCLUSIONSThere are large disparities in relative survival among patients with HPV‐associated cancers by sex, race, and age. HPV vaccination and improved access to screening (of cancers for which screening tests are available) and treatment, especially among groups that experience higher incidence and lower survival, may reduce disparities in survival from HPV‐associated cancers. Cancer 2018;124:203‐211. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.
Should body image programs be inclusive? A focus group study of college students
Authors: Ciao Anna C. , Ohls Olivia C. , Pringle Kevin D. 
Published: November 2017

AbstractObjectiveMost evidence‐based body image programs for college students (e.g., the Body Project) are designed for female‐only audiences, although body dissatisfaction is not limited to female‐identified individuals. Furthermore, programs do not explicitly discuss diversity, although individuals with marginalized gender, racial, and sexual identities may be particularly vulnerable to body image disturbances. Making programs more inclusive may increase their disseminability.MethodThis qualitative study examined the feasibility of adapting the Body Project for universal and inclusive use with college students. Participants (N = 36; M age = 21.66 years; 73% female‐identified; 20% sexual minority; 23% racial minority) attended one of five semi‐structured focus groups to explore the inclusivity of appearance‐based cultural norms using adapted Body Project activities and discuss the feasibility of universal and inclusive interventions. Inductive qualitative content analysis with three‐rater consensus identified focus group themes.ResultsThere was consensus that inclusive interventions could have a positive impact (broadening perspectives, normalizing body image concerns, increasing awareness) despite potential barriers (poor diversity representation, vulnerability). There was strong consensus regarding advice for facilitating inclusive interventions (e.g., skilled facilitation, education, increasing diversity).DiscussionResults suggest that inclusive body image programs are desirable and provide a framework for creating the EVERYbody Project, a program for more universal audiences.
Early childhood adversities and risk of eating disorders in women: A Danish register‐based cohort study
Authors: Larsen Janne Tidselbak , Munk‐Olsen Trine , Bulik Cynthia M. , Thornton Laura M. , Koch Susanne Vinkel , Mortensen Preben Bo , Petersen Liselotte 
Published: November 2017

AbstractObjectivePrevious studies evaluating the association between early childhood adversities and eating disorders have yielded conflicting results. The aim of this study is to examine the association between a range of adversities and risk of anorexia nervosa (AN), bulimia nervosa (BN), and eating disorder not otherwise specified (EDNOS) in 495,244 women.MethodIn this nationwide, register‐based cohort study, nine types of early childhood adversity (family disruption, residential instability, placement in out‐of‐home care, familial death, parental somatic illness, parental psychiatric illness, parental disability, severe parental criminality, and parental substance use disorder) were defined and exposure during the first 6 years of life was determined. Hazard ratios for eating disorders were calculated using Cox regression.ResultsFew adversities were significantly associated with AN, and for each, the presence of the adversity was associated with lower risk for AN. BN, and EDNOS were positively associated with several types of adversities. AN rates were unchanged or reduced by up to 54% by adversities, whereas rates of BN and EDNOS were unchanged or increased by adversities by up to 49 and 89%, respectively.DiscussionOur findings indicate that childhood adversities appear to be associated with an increased risk of BN and in particular EDNOS, whereas they seem to be either unassociated or associated with a decreased risk of AN.
Predicting landscape effects of Mississippi River diversions on soil organic carbon sequestration
Authors: Wang Hongqing , Steyer Gregory D. , Couvillion Brady R. , Beck Holly J. , Rybczyk John M. , Rivera‐Monroy Victor H. , Krauss Ken W. , Visser Jenneke M. 
Published: November 2017

AbstractLarge Mississippi River (MR) diversions (peak water flow >1416 m3/s and sediment loads >165 kg/s) have been proposed as part of a suite of coastal restoration projects and are expected to rehabilitate and rebuild wetlands to alleviate the significant historic wetland loss in coastal Louisiana. These coastal wetlands are undergoing increasing eustatic sea‐level rise, land subsidence, climate change, and anthropogenic disturbances. However, the effect of MR diversions on wetland soil organic carbon (SOC) sequestration in receiving basins remains unknown. The rate of SOC sequestration or carbon burial in wetlands is one of the variables used to assess the role of wetland soils in carbon cycling and also to construct wetland carbon budgets. In this study, we examined the effects of MR water and sediment diversions on landscape‐scale SOC sequestration rates that were estimated from vertical accretion for the next 50 yr (2010–2060) under two environmental (moderate and less optimistic) scenarios. Our analyses were based on model simulations taken from the Wetland Morphology model developed for Louisiana's 2012 Coastal Master Plan. The master plan modeled a “future‐without‐action” scenario as well as eight individual MR diversion projects in two of the hydrologic basins (Barataria and Breton Sound). We examined the effects that discharge rates (peak flow) and locations of these individual diversion projects had on SOC sequestration rates. Modeling results indicate that large river diversions are capable of improving basin‐wide SOC sequestration capacity (162–222 g C·m−2·yr−1) by up to 14% (30 g C·m−2·yr−1) in Louisiana deltaic wetlands compared to the future‐without‐action scenario, especially under the less optimistic scenario. When large river diversions are placed in the upper receiving basin, SOC sequestration rates are 3.7–10.5% higher (6–24 g C·m−2·yr−1) than when these structures are placed in the lower receiving basin. Modeling results also indicate that both diversion discharge and location have large effects on SOC sequestration in low‐salinity (freshwater and intermediate marshes) as compared to high‐salinity marshes (brackish and saline marshes).
Freshwater eutrophication drives sharp reductions in temporal beta diversity
Authors: Cook Stephen C. , Housley Lauren , Back Jeffrey A. , King Ryan S. 
Published: November 2017

AbstractEutrophication has become one of the most widespread anthropogenic forces impacting freshwater biological diversity. One potentially important mechanism driving biodiversity changes in response to eutrophication is the alteration of seasonal patterns of succession, particularly among species with short, synchronous, life cycles. We tested the hypothesis that eutrophication reduces seasonally driven variation in species assemblages by focusing on an understudied aspect of biodiversity: temporal beta diversity (βt). We estimated the effect of eutrophication on βt by sampling benthic macroinvertebrate assemblages bimonthly for two years across 35 streams spanning a steep gradient of total phosphorus (P) and benthic algal biomass (as chlorophyll a [chl a]). Two widely used metrics of β diversity both declined sharply in response to increasing P and chl a, regardless of covariates. The most parsimonious explanatory model for βt included an interaction between P and macroinvertebrate biomass, which revealed that βt was lower when macroinvertebrate biomass was relatively high. Macroinvertebrate biomass explained a greater amount of deviance in βt at lower to moderate concentrations of P, providing additional explanatory power where P concentration alone was unable to fully explain declines in βt. Chl a explained similar amounts of deviance in βt in comparison to the best P model, but only when temperature variability, which was positively related to βt, also was included in the model. Declines in βt suggest that nutrient enrichment decreases the competitive advantage that specialists gain by occupying particular temporal niches, which leads to assemblages dominated by generalists that exhibit little seasonal turnover. The collapse of seasonal variation in assemblage composition we observed in our study suggests that treating dynamic communities as static assemblages is a simplification that may fail to detect the full impact of anthropogenic stressors. Our results show that eutrophication leads to more temporally homogenous communities and therefore degrades a fundamental facet of biodiversity.
Chronic intensive care‐related pain: Exploratory analysis on predictors and influence on health‐related quality of life
Authors: Baumbach P. , Götz T. , Günther A. , Weiss T. , Meissner W. 
Published: November 2017

AbstractBackgroundThere is growing evidence for the development of chronic pain after intensive care. Nonetheless, there is only limited knowledge about factors leading to chronic intensive care‐related pain (CIRP). Thus, the primary objective was the identification of predictors of CIRP. Moreover, we aimed to assess the impact of CIRP on patients’ health‐related quality of Life (HRQOL).MethodsComprehensive information on patients’ pain before ICU admission and present pain was collected longitudinally by means of the German Pain Questionnaire 6 and 12 months after ICU discharge (ICUDC). In addition, a subsample of patients underwent Quantitative Sensory Testing (QST). We used Generalized Estimating Equations to identify predictors of CIRP with logistic regression models.ResultsIn total, 204 patients (197/159 at 6/12 months after ICUDC) were available for the analyses. In the multivariate models, moderate to severe average pain in the 4 weeks after ICUDC, lower age, female sex, increased inflammation and chronic pain conditions and increased levels of anxiety before ICU admission were predictive for CIRP. In addition, small fibre deficits and lower disease severity were associated with CIRP in the QST subsample (81 patients, 77/55 at 6/12 months after ICUDC). Patients with CIRP reported significantly lower HRQOL than patients without CIRP.ConclusionsChronic intensive care‐related pain is associated with specific decrements in HRQOL. Knowledge about the identified predictors is of clinical and scientific importance and might help to reduce the incidence of CIRP.SignificanceChronic intensive care‐related pain is associated with specific decrements in health‐related quality of life. While most of the identified predictors for CIRP can only be considered as risk factors, especially adequate (post‐) acute pain management should be studied as preventive strategy.
Assessment and manifestation of central sensitisation across different chronic pain conditions
Authors: Arendt‐Nielsen L. , Morlion B. , Perrot S. , Dahan A. , Dickenson A. , Kress H.G. , Wells C. , Bouhassira D. , Drewes A. Mohr 
Published: November 2017

AbstractDifferent neuroplastic processes can occur along the nociceptive pathways and may be important in the transition from acute to chronic pain and for diagnosis and development of optimal management strategies. The neuroplastic processes may result in gain (sensitisation) or loss (desensitisation) of function in relation to the incoming nociceptive signals. Such processes play important roles in chronic pain, and although the clinical manifestations differ across condition processes, they share some common mechanistic features. The fundamental understanding and quantitative assessment of particularly some of the central sensitisation mechanisms can be translated from preclinical studies into the clinic. The clinical perspectives are implementation of such novel information into diagnostics, mechanistic phenotyping, prevention, personalised treatment, and drug development. The aims of this paper are to introduce and discuss (1) some common fundamental central pain mechanisms, (2) how they may translate into the clinical signs and symptoms across different chronic pain conditions, (3) how to evaluate gain and loss of function using quantitative pain assessment tools, and (4) the implications for optimising prevention and management of pain. The chronic pain conditions selected for the paper are neuropathic pain in general, musculoskeletal pain (chronic low back pain and osteoarthritic pain in particular), and visceral pain (irritable bowel syndrome in particular). The translational mechanisms addressed are local and widespread sensitisation, central summation, and descending pain modulation.SignificanceCentral sensitisation is an important manifestation involved in many different chronic pain conditions. Central sensitisation can be different to assess and evaluate as the manifestations vary from pain condition to pain condition. Understanding central sensitisation may promote better profiling and diagnosis of pain patients and development of new regimes for mechanism based therapy. Some of the mechanisms underlying central sensitisation can be translated from animals to humans providing new options in development of therapies and profiling drugs under development.
Electrochemical Studies of Ethoxyquin and its Determination in Salmon Samples by Flow Injection Analysis with an Amperometric Dual Detector
Authors: Vandeput Marie , Rodríguez‐Gómez Rocío , Izere Ange‐Michaëlla , Zafra‐Gómez Alberto , De Braekeleer Kris , Delporte Cédric , Van Antwerpen Pierre , Kauffmann Jean‐Michel 
Published: November 2017

AbstractEthoxyquin (EQ) is an antioxidant widely used in the food industry. Some concerns for human health have been reported since its utilization in animal feed may lead to residues in human food such as salmon samples. This work aimed to investigate the electrochemical behavior of EQ and its major oxidation products namely a dimer of EQ (EQDM) and ethoxyquin quinone imine (EQI) by cyclic voltammetry (CV) at a carbon screen printed electrode (cSPE). The stability of these products and their reactivity against glutathione (GSH) were also studied. Oxidized products and thiol adducts were identified by a microelectrolysis of an EQ solution onto a cSPE in the absence and in the presence of GSH. The products were analyzed off‐line, by liquid chromatography coupled to a mass spectrometer (LC‐MS). One of the generated product (EQI) was shown to be highly reactive towards GSH. Based on the redox pattern of EQ, a flow injection analysis with a dual cSPE was developed in order to detect in a rapid manner EQ in salmon samples. Since matrix effects were observed, matrix‐matched calibration curves with spiked samples were built. A linear response was obtained between 20–100 μM and a limit of detection (LOD) of 7.5 μM (8.2 mg/kg of salmon). Trueness was assessed with recovery assays at three levels of concentration. The recovery was close to 100 %. Precision was determined as RSD (%) with values lower than 6 % in all cases.
A color‐code for glycosaminoglycans identification by means of polyacrylamide gel electrophoresis stained with the cationic carbocyanine dye Stains‐all
Authors: Andrade João Pedro Souza , Oliveira Caroline Pacheco , Tovar Ana Maria Freire , Mourão Paulo Antonio de Souza , Vilanova Eduardo 
Published: November 2017

AbstractCationic dyes such as toluidin blue are commonly employed to visualize glycosaminoglycans (GAGs) on electrophoresis gels; however, the carbocyanine‐based dye Stains‐all have been increasingly used to stain the non‐sulfated hyaluronic acid and other GAGs in submicrogram quantities. In this short communication, we demonstrate that Stains‐all is able to stain the most common GAGs on polyacrylamide gels with distinct and contrasting colors in a reproducible manner. We also show that this staining method is useful to identify GAGs present both in mixtures and in submicrogram quantities. Therefore, Stains‐all has shown to be useful in identifying GAGs on polyacrylamide gels with basis on their specific colors, at least on screening level.