bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concentrations of neopterin, kynurenine and tryptophan in wound secretions of patients with breast cancer and malignant melanoma: a pilot study
Authors: Mergancová Jana , Javorská Lenka , Šiller Jiří , Sákra Lukáš , Mergancová Jindřiška , Solichová Dagmar , Krčmová Lenka Kujovská , Melichar Bohuslav , Mohelníková-Duchoňová Beatrice , Študentová Hana , Klos Dušan 
Published: November 2017

AbstractThe aim of the present pilot study was to investigate the concentrations of neopterin, kynurenine and tryptophan in wound secretion in patients undergoing surgery for breast cancer or malignant melanoma. Twenty-two patients, 16 females and 6 males, undergoing surgery for breast cancer (n=15) or malignant melanoma (n=7) were evaluated. Neopterin, kynurenine and tryptophan were determined using a high-performance liquid chromatography method. When the concentrations in wound secretions from the primary breast tumor and the axilla were compared, the neopterin/tryptophan ratio was significantly higher in the tumor wound secretions (0.92±0.41 vs. 0.61±0.14 mmol/mol; p=0.049), but no significant differences were observed in neopterin (49.2±28.6 vs. 31.5±11.1 nmol/L), tryptophan (52.9±13.0 vs. 51.2±13.3 μmol/L) and kynurenine concentrations (5.97±7.49 vs. 5.34±6.25 μmol/L) and kynurenine/tryptophan ratio (108.1±107.7 vs. 103.5±106.7 mmol/mol). No marked differences were noted in neopterin, tryptophan and kynurenine concentrations and kynurenine/tryptophan and neopterin/tryptophan ratios in sequential samples from the axilla of breast cancer patients obtained on days 1 and 2. In conclusion, present data demonstrate that the measurement of neopterin, kynurenine and tryptophan can be used to monitor local immune response after cancer surgery.
The relationship between chondromalacia patella, medial meniscal tear and medial periarticular bursitis in patients with osteoarthritis
Authors: Resorlu Mustafa , Doner Davut , Karatag Ozan , Toprak Canan Akgun 
Published: November 2017

Abstract

Background
This study investigated the presence of bursitis in the medial compartment of the knee (pes anserine, semimembranosus-tibial collateral ligament, and medial collateral ligament bursa) in osteoarthritis, chondromalacia patella and medial meniscal tears.

Patients and methods
Radiological findings of 100 patients undergoing magnetic resonance imaging with a preliminary diagnosis of knee pain were retrospectively evaluated by two radiologists. The first radiologist assessed all patients in terms of osteoarthritis, chondromalacia patella and medial meniscal tear. The second radiologist was blinded to these results and assessed the presence of bursitis in all patients.

Results
Mild osteoarthritis (grade I and II) was determined in 55 patients and severe osteoarthritis (grade III and IV) in 45 cases. At retropatellar cartilage evaluation, 25 patients were assessed as normal, while 29 patients were diagnosed with mild chondromalacia patella (grade I and II) and 46 with severe chondromalacia patella (grade III and IV). Medial meniscus tear was determined in 51 patients. Severe osteoarthritis and chondromalacia patella were positively correlated with meniscal tear (p < 0.001 and p = 0.018, respectively). Significant correlation was observed between medial meniscal tear and bursitis in the medial compartment (p = 0.038). Presence of medial periarticular bursitis was positively correlated with severity of osteoarthritis but exhibited no correlation with chondromalacia patella (p = 0.023 and p = 0.479, respectively). Evaluation of lateral compartment bursae revealed lateral collateral ligament bursitis in 2 patients and iliotibial bursitis in 5 patients.

Conclusions
We observed a greater prevalence of bursitis in the medial compartment of the knee in patients with severe osteoarthritis and medial meniscus tear.
Mothering under the influence: how perinatal drugs of abuse alter the mother-infant interaction
Authors: Brancato Anna , Cannizzaro Carla 
Published: December 2017

AbstractAlthough drug-abusing women try to moderate their drug and alcohol use during pregnancy, they often relapse at a time when childcare needs are high and maternal bonding is critical to an infant’s development. In the clinical setting, the search for the neural basis of drug-induced caregiving deficits is complex due to several intervening variables. Rather, the preclinical studies that control for drug dose and regimen, as well as for gestational and postpartum environment, allow a precise determination of the effects of drugs on maternal behaviour. Given the relevance of the issue, this review will gather reports on the phenotypic correlates of maternal behaviour in preclinical studies, and focus on the detrimental consequences on the mother-infant interaction exerted by the perinatal use of alcohol, nicotine, cannabis, cocaine and stimulants and opiates. The drug-induced disruptions of this maternal repertoire are associated with adverse maternal and infant outcomes. A comprehensive overview will help promote the refinement of the treatment approaches toward maternal drug use disorders and maternal misbehaviour, in favour of augmented parenting resiliency.
Surface modification on dispersion and enhancement of PVA fibers in fiber-reinforced cementitious composites
Authors: Shui-dong Lin , Li Li 
Published: December 2017

AbstractIn this paper, non-ionic polyoxyethylene ether was used to modify the surface of poly(vinyl alcohol) (PVA) fibers and to improve their dispersion in cement mortar. The results showed that surface modification could apparently improve the dispersion of PVA fibers in cement mortar by weakening the original intermolecular hydrogen bonds between the adjacent hydroxyl groups on the surface of PVA fibers and increasing the formation of hydrogen bonds between PVA fibers and cement mortar. After modification, the advancing contact angle and the receding contact angle of the fibers were respectively reduced from 44.2° to 34.7° and from 38.8° to 33.1°, and the dispersion coefficient of the fibers was increased from 0.85 to 0.95. Owing to the improved interactions between modified PVA fibers and cement mortar and to the good dispersion of the fibers in the matrix, the fibers had a superior energy absorption capacity and showed a ductile fracture, leading to higher flexural strength, bending modulus and toughness of fiber-reinforced cementitious composites.
Restrained shrinkage cracking of self-consolidating concrete roads
Authors: Akgungor Ali Payidar , Sevim Ozer , Kalkan Ilker , Demir Ilhami 
Published: November 2017

Abstract
The present study is dedicated to investigate the liability of continuously reinforced concrete pavement (CRCP) cast with self-consolidating concrete (SCC) to restrained shrinkage cracking and the values of restraint stresses in these pavements. SCC, which is becoming increasingly popular due to its several superiorities over conventionally vibrated concrete (CVC), has higher amounts and rates of shrinkage compared to CVC. The higher risk of restrained shrinkage cracking of SCC is a great cause of concern in pavement construction as the penetration of water, chemicals, and salts increases the risk of corrosion of reinforcement. In the present study, an analytical restraint stress expression was developed for typical CRC pavements by modifying the restraint stress equation developed previously for RC beams. Using this equation, the restraint stresses induced to the longitudinal reinforcement by the rigid pavement, cast with CVC or SCC, were calculated for eight different example sections. These restraint stress values were found to reach up to 50% of the limit stresses of bars, allowed by the design guidelines, when the pavement is cast with SCC. The amounts of longitudinal reinforcement used in typical CRCP roads were found to be more critical when the pavement is cast with SCC.
Synthesis and antimicrobial activities of some novel thiazole compounds
Authors: Turan-Zitouni Gülhan , Kaya Çavuşoğlu Betül , Sağlık Begüm Nurpelin , Acar Çevik Ulviye 
Published: November 2017

Abstract

Objective
The advent of resistant pathogenic microorganisms against current antimicrobial drugs prompted scientists to investigate novel molecules with new mechanisms. In this paper, some new 2-[2-[4-(ethyl/phenyl)cyclohexylidene]hydrazinyl]-4-(4-substitutedphenyl)thiazole (2a–2o) derivatives were synthesized and studied for their antimicrobial activities.

Materials and methods
The title compounds (2a–2o) were obtained via the reaction of 4-(ethyl/phenyl)cyclohexane-1-one with appropriate phenacyl bromide in ethanol at room temperature. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR, 13C-NMR, HRMS and elemental analysis. Antimicrobial activity of the compounds was measured by using broth microdilution method. Chloramphenicol and ketoconazole were used as reference drugs.

Results
Among the synthesized compounds, 2-[2-(4-phenylcyclohexylidene)hydrazinyl]-4-phenylthiazole (2h) and 2-[2-(4-phenylcyclohexylidene)hydrazinyl]-4-(4-chlorophenyl)thiazole (2l) have been found to exhibit potency almost four-fold better than ketoconazole against C. albicans with MIC90 value of 1.95.

Conclusion
The current study contributed to the knowledge of the antimicrobial activity of thiazole bearing compounds.
Examining the Influence of Exercise Intensity and Hydration on Gastrointestinal Temperature in Collegiate Football Players
Authors: DeMartini-Nolan Julie K. , Martschinske Jessica L. , Casa Douglas J. , Lopez Rebecca M. , Stearns Rebecca L. , Ganio Matthew S. , Coris Eric 
Published: November 2017

Abstract
DeMartini-Nolan, JK, Martschinske, JL, Casa, DJ, Lopez, RM, Stearns, RL, Ganio, MS, and Coris, E. Examining the influence of exercise intensity and hydration on gastrointestinal temperature in collegiate football players. J Strength Cond Res 32(10): 2888–2896, 2018—Debate exists regarding the influence of intensity and hydration on body temperature during American football. The purpose of this study was to observe body core temperature responses with changes in intensity and hydration. Twenty-nine male football players (age = 21 ± 1 year, height = 187 ± 9 cm, mass = 110.1 ± 23.5 kg, body mass index [BMI] = 31.3 ± 5.0, and body surface area [BSA] = 2.34 ± 0.27 m2) participated in 8 days of practice in a warm environment (wet bulb globe temperature: 29.6 ± 1.6° C). Participants were identified as starters (S; n = 12) or nonstarters (n = 17) and linemen (L; n = 14) or nonlinemen (NL; n = 15). Variables of interest included core body temperature (T), hydration status, and physical performance characteristics as measured by a global positioning system. Intensity measures of average heart rate (138 ± 9 bpm), low-velocity movement (4.2 ± 1.7%), high-velocity movement (0.6 ± 0.6%), and average velocity (0.36 ± 0.10 m·s−1) accounted for 42% of the variability observed in T (38.32 ± 0.34° C, r = 0.65, p = 0.01). Hydration measures (percent body mass loss = −1.56 ± 0.80%, urine specific gravity [Usg] = 1.025 ± 0.006, and urine color [Ucol] = 6 ± 1) did not add to the prediction of T (p = 0.83). Metrics of exercise intensity accounted for 39% of the variability observed in maximum T (38.83 ± 0.42° C, r = 0.62, p = 0.02). Hydration measures did not add to this prediction (p = 0.40). Low-velocity movement, high-velocity movement, average velocity, BMI, and BSA were significantly different (p = 0.002, p < 0.001, p = 0.02, p < 0.001, p < 0.001, respectively) between L vs. NL. Heart rate and T were not different between L and NL (p > 0.05). Exercise intensity primarily accounted for the rise in core body temperature. Although L spent less time at higher velocities, T was similar to NL, suggesting that differences in BMI and BSA added to thermoregulatory strain.
Motor Skills of Children and Adolescents With Obesity and Severe Obesity—A CIRCUIT Study
Authors: Häcker Anna-Luisa , Bigras Jean-Luc , Henderson Mélanie , Barnett Tracie A. , Mathieu Marie-Eve 
Published: November 2017

Abstract
Häcker, A-L, Bigras, J-L, Henderson, M, Barnett, TA, and Mathieu, M-E. Motor skills of children and adolescents with obesity and severe obesity—a CIRCUIT study. J Strength Cond Res 34(12): 3577–3586, 2020—During childhood, excessive weight is negatively associated with the development of motor skills, with overweight children or children with obesity having poorer motor skills compared with children with normal weight. The objectives of the current study are to identify the differences in motor skills between children and adolescents with obesity and severe obesity and the extent of this difference. To do so, we examined cross-sectionally 165 subjects. Physical fitness was analyzed in both subjects with obesity (>97th to 99.9th body mass index [BMI] percentile) and severe obesity (>99.9th BMI percentile) using 8 standardized tests: sit-and-reach, grip force, sit-ups, push-ups, balance, hand-eye coordination, standing long jump and 5-m shuttle run. Poorer performance were observed in subjects with severe obesity in sit-ups (children: 59%; 18.6 ± 17.0 vs. 29.5 ± 23.2 percentile value, p = 0.008), balance (adolescent: 59%; 12.1 ± 12.2 vs. 19.3 ± 13.9 seconds, p = 0.034), and in the 5-m shuttle run (children: 49%; 14.0 ± 13.9 vs. 20.8 ± 19.4 percentile value, p = 0.046; adolescents: 11%; 13.2 ± 2.2 vs. 11.8 ± 1.6 seconds, p = 0.008) compared with obese counterparts. In conclusion, although physical performance was found to be similar between the different obesity levels for most tests, youth with severe obesity demonstrated impairments ranging from 11 to 59% in specific tests.
Reliability and Validity of a Submaximal Warm-up Test for Monitoring Training Status in Professional Soccer Players
Authors: Rabbani Alireza , Kargarfard Mehdi , Twist Craig 
Published: November 2017

Abstract
Rabbani, A, Kargarfard, M, and Twist, C. Reliability and validity of a submaximal warm-up test for monitoring training status in professional soccer players. J Strength Cond Res 32(2): 326–333, 2018—Two studies were conducted to assess the reliability and validity of a submaximal warm-up test (SWT) in professional soccer players. For the reliability study, 12 male players performed an SWT over 3 trials, with 1 week between trials. For the validity study, 14 players of the same team performed an SWT and a 30-15 intermittent fitness test (30-15IFT) 7 days apart. Week-to-week reliability in selected heart rate (HR) responses (exercise heart rate [HRex], heart rate recovery [HRR] expressed as the number of beats recovered within 1 minute [HRR60s], and HRR expressed as the mean HR during 1 minute [HRpost1]) was determined using the intraclass correlation coefficient (ICC) and typical error of measurement expressed as coefficient of variation (CV). The relationships between HR measures derived from the SWT and the maximal speed reached at the 30-15IFT (VIFT) were used to assess validity. The range for ICC and CV values was 0.83–0.95 and 1.4–7.0% in all HR measures, respectively, with the HRex as the most reliable HR measure of the SWT. Inverse large (r = −0.50 and 90% confidence limits [CLs] [−0.78 to −0.06]) and very large (r = −0.76 and CL, −0.90 to −0.45) relationships were observed between HRex and HRpost1 with VIFT in relative (expressed as the % of maximal HR) measures, respectively. The SWT is a reliable and valid submaximal test to monitor high-intensity intermittent running fitness in professional soccer players. In addition, the test's short duration (5 minutes) and simplicity mean that it can be used regularly to assess training status in high-level soccer players.
Functional Layer Designation of Combined Chip Seal and Slurry Seal in Airport Pavement
Authors: Yuan Jie , Xu Siyuan , Hou Xiangdao , Xiao Feipeng , Jiang Changshan , Luo Yong 
Published: December 2017

Abstract
With the increasing attention to preventive maintenance and rehabilitation of asphalt pavement, asphalt emulsions have gained popularity. Synchronous chip seal (SCS) and slurry seal (SS) are widely used in pavement preservation due to their low cost and efficiency but are not prevalent in new pavement construction, especially for airport pavement. The objective of this study was to characterize the asphalt emulsions and functional layers of combined chip seal and SS through conventional test methods for asphalt emulsions, asphalt binders, and chip and slurry seals, including setting time, residual amount on sieve of 16 mesh, Engler viscosity, standard viscosity, residue content, penetration, ductility, failure temperature, wet track abrasion test, and load wheel test. Differential scanning calorimetry (DSC) was also conducted to explore the energy differences amongst various emulsions. In addition, trial pavements were also tested in the laboratory and field to evaluate the waterproof performances of the functional layers. The results of material tests showed that SS-1 and SCS-2 were optimum emulsions. The laboratory waterproof test on trial pavement met the requirement of standards and the trial airport pavement emphasized the importance of compaction during construction.
Worlds Conflicting
Authors: Vienne Florence 
Published: November 2017

François-Vincent Raspail (1794–1878) and Theodor Schwann (1810–1882) postulated—in 1827 and 1838, respectively—that plants and animals consist of, and originate from, cells. Whereas Raspail is mainly remembered for his involvement in the revolutions of 1830 and 1848, little is known about his scientific work. Schwann, by contrast, is regarded as one of the founders of cell theory, but historians of biology have hardly taken his philosophical, religious, and political ideas into account. Paying particular attention to Schwann’s unpublished writings, this paper reconstructs the research agendas of Raspail and Schwann, and contrasts the philosophical and political beliefs and incentives behind them. Whereas Raspail was a proponent of republicanism and materialism, Schwann opposed the modernist agenda of explaining nature and humankind without God, as well a democratic reshaping of society. Contrary to the prevailing historical narrative, this paper argues that cell theory did not emerge exclusively in conjunction with the rise of liberalism and materialism. Rather, the idea of a unifying principle of organic development encompassed different and even antagonistic visions of nature, humankind, society, and the role of religion in science.
This essay is part of a special issue entitled REVOLUTIONARY POLITICS AND BIOLOGICAL ORGANIZATION IN NINETEENTH-CENTURY FRANCE AND GERMANY edited by Lynn K. Nyhart and Florence Vienne.
Biological and Social New Orders
Authors: Thomas Marion 
Published: November 2017

In this paper, I examine the intertwined science, politics, and religion of a major figure of nineteenth-century French biology, the Parisian professor of histology Charles Robin (1821–1885). Historiography generally associates his name with France’s rejection of the cell theory formulated by Schwann and then Virchow in the 1830s–1850s. One of the main factors put forward is the influence of Comtean positivism. Here, I propose to go beyond this historiography and discuss not only convergences but also divergences between Robin’s and Comte’s visions of the organism and society. Moreover, I analyze Robin’s research agenda in light of the political ideas he defended as a republican in the context of the emergence of the Third Republic. At first sight, Robin’s political activity (marked by his late tenure as senator) may initially appear disconnected from his scientific agenda. However, I argue that Robin’s approaches to different areas of knowledge (biology, sociology, politics, and metaphysics) were mutually supportive and lent one another authority, especially through the parallel structure and shared vocabulary of their discourses. Ultimately, I demonstrate that Robin’s biological materialism, combined with his outspoken anticlericalism, constitutes a political stance, and show how the concept of “solidarity” helped him to cast a new light on the relations between the parts and the whole, both in biology and social policy.
This essay is part of a special issue entitled REVOLUTIONARY POLITICS AND BIOLOGICAL ORGANIZATION IN NINETEENTH-CENTURY FRANCE AND GERMANY edited by Lynn K. Nyhart and Florence Vienne.
Hepatocellular Carcinoma Occurrence and Recurrence after Antiviral Treatment in HCV-Related Cirrhosis. Are Outcomes Different after Direct Antiviral Agents? A Review
Authors: Spârchez Zeno , Mocan Tudor 
Published: November 2017

Hepatitis C virus (HCV) infection is one of the major causes of hepatocellular carcinoma (HCC) worldwide. In the last decades, several studies have showed a lower rate of HCC occurrence or recurrence in patients with HCV-related cirrhosis after interferon-based antiviral therapies compared to untreated controls, even without reaching viral clearance. Unfortunately, interferon regimens could only yield viral clearance in approximately half of the patients. The recent development of new all-oral regimens with direct-acting antivirals (DAAs) has radically improved the cure rate to above 90%. In respect to these findings, many would have thought that interferon-free regimens would decrease the development and recurrence of HCC. Literature data have unexpectedly reported high rates of both the occurrence and recurrence of HCC after therapy with DAAs. However, it is probably too early to express some concerns. More recent data showed that both occurrence and recurrence of HCC are decreased by the DAAs. Interferon-free therapy is definitely not without limits. Together with the initial thoughts of an increased risk of HCC, these may lead to an unwanted restricted access to interferon-free regimens in specific subpopulations. This issue should be settled as soon as possible because millions of hepatitis C patients are and will be using DAAs in the present and future. Our purpose is to review the existing literature and to offer a more precise and rational interpretation of the existing data.Key words: – – e – .Abreviations: AFP: alpha-fetoprotein; DAA: direct antiviral agent; HCC: hepatocellular carcinoma; HCV: hepatitis C virus; HR: hazard ratio; IFN: interferon; LDV: Ledispavir; SMV: Simeprevir; SOF: Sofosbuvir; SVR: sustained virologic response.