bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Herpes Simplex Virus 2 (HSV-2) infection and associated risk factors in a cohort of HIV negative women in Durban, South Africa
Authors: Daniels Brodie , Wand Handan , Ramjee Gita ,   the MDP Team
Published: December 2016

Abstract
Background
Herpes Simplex Virus 2 (HSV-2) is one of the most common sexually transmitted infections (STIs) worldwide and is a risk factor for the acquisition and transmission of other STIs, including HIV. We determined the prevalence and predictors of HSV-2 infection among women screened for a HIV prevention trial in Durban, South Africa. Univariate and multivariate logistic and Cox regression models were used to determine the correlates and predictors of HSV-2 infection at enrolment and seroconversion during the study respectively.

Results
Prevalence of HSV-2 at screening was 65% and crude incidence was 22.3 per 100 person-years (PY) (95% CI 20.4–24.3). The HIV seroconversion was significantly higher among those testing positive for HSV-2 at baseline compared to women who were negative [8.7 per 100 person years (PY) versus 5.2 per 100 PY; (p < 0.001)]. In univariate analysis, age was determined to be the most significant predictor for HSV-2 diagnosis, while co-infection with syphilis was also a significant predictor, while age and co-infection with syphilis remained the two most significant predictors of having HSV-2 in multivariate analysis at baseline. Consistent with these results, along with HIV seroconversion, age was also identified as a significant predictor for incidence of HSV-2.

Conclusion
Given the unacceptably high prevalence and incidence rates of HSV-2 infection reported here, HSV-2 and general STI education needs to be reinforced in these communities, with a focus on condom education for prevention. HSV-2 has emerged as the most prevalent STI which is most often asymptomatic and unrecognized, and which increases women’s risk of acquiring other STIs, including HIV.
From Representation to Corposubjectivation
Authors: Pons Rabasa Alba 
Published: December 2016

Abstract
As part of the doctoral research project “Social Transformations and Corporeal Micropolitics: A Study on the Process of Normalization of Trans* in Mexico City,” the author has acted as a participant observer in the Trans* Support Group of the Condesa Specialized Clinic of Mexico City since 2012. The support group is inside the first and primary public health institution that has offered medical attention to trans* persons, whether transsexual or transgender, since 2009 as a part of public insurance. This article presents as much the history of the group—its origins and particularities, as well as its development as a project under the aegis of the clinic but not planned or regulated by it—as a first dialogue between processes of corposubjectivation among those who attend the group and the clinic context, as well as with the process of the normalization of trans* in Mexico City in general. The objective is to reflect ethnographically on the embodiment of gender as norm and leakage, showing the constant tension between the representation and the experience of it.
Translating Hijra into Transgender
Authors: Roy Jeff 
Published: December 2016

Abstract
This article analyzes discourses and performance practices in India's hijra and transgender communities through a comparison of badhais (ritualistic acoustic music and dance performed by hijras) and dances from the professional transgender-led troupe known as the Dancing Queens. Differences between the two evince the transformation of regimes and representations of hijra identity from devalorized codes of social difference to respectable, middle-class ones within a transgender narrative of self-understanding and personal empowerment.
Pedro Lemebel and the Translatxrsation
Authors: Concilio Arielle A. 
Published: December 2016

Abstract
Like transgender studies, literary translation has historically suffered marginalization within the academy and has only recently become established. The marginalization of both, it seems, stems from rigid binaries—namely, the binaries of male/female and man/woman in the context of the transgender, and the binaries of author/translator, original/translation, and source language/target language in the context of translation. By applying the deconstructive work of transgender and queer theory that undertakes the project of destabilizing cisgender, heteronormative, patriarchal systems, we can dismantle these binaries to reconceptualize the translator as the translatxr—a trans*, nonbinary, or genderqueer subjectivity—and translation as translatxrsation, a nonbinary embodied practice with the potential to produce multilingual, decolonizing strategies and discourses. Such a practice actively resists the erasure and colonization of texts by and about trans*, trans, nonbinary, or genderqueer persons and lives. This article looks to the work of Chilean writer and performance artist Pedro Lemebel's urban chronicles to reveal the antinormalizing, decolonizing practice of becoming-translation. The article concludes with the translatxrsation of Lemebel's performance poem “Manifiesto,” to reveal the embodiment of the translatxrsation.
Untranslating Gender in Trish Salah'sLyric Sexology Vol. 1
Authors: Gabriel Kay 
Published: December 2016

AbstractThe author explores the thematics of transsexuality, untranslatability, and figuration in a recent volume of poetry by the Canadian poet and scholar Trish Salah, Lyric Sexology Vol. 1. Lyric Sexology confronts historical, aesthetic, and political questions that are best understood in the framework of translation and its failure. Drawing on Barbara Cassin's philosophical reflections on untranslatables, the author argues that gender as a representational system necessarily experiences trans configurations of gender as untranslatables, which it “never ceases (not) translating.” The author deploys Salah's collection of poems, which explores a number of historical discourses and sciences oriented around understanding transsexuality, to help think through some of the questions that the paradigm of untranslatability opens. This article argues that Lyric Sexology stages an analogy between linguistic and literary translations and historical attempts to categorize transsexuality, thus rendering transsexuality legible within normative gender categories. In this account, categorization is treated as a historical analogue of translation, the repetitions and failures of which can be understood as a response to transsexuality as an untranslatable. Through a reading of Salah's poems, the author develops an interpretation of categorization as dependent upon figuration to achieve its intended effect of translating its targets into, in Salah's words, one “of those things you have words for.” The author's interpretation of Lyric Sexology through the history it proposes thus helps her to develop a paradigm for understanding the functions of untranslatability and figuration in determining the past and present configurations of trans social relations.
Translating the Human
Authors: Strassfeld Max 
Published: December 2016

AbstractDiscussions of gender variance abound in rabbinic literature, a corpus of canonical Jewish texts that originate in the first six centuries of the common era. This article reads the most central text on the androginos, a person who is described by the rabbis as having dual genitalia. Both English and Hebrew are languages that ostensibly require the assignment of male or female; I discuss the challenges of translating the androginos while not foreclosing the question of hir gender just as it is being raised by the rabbis. I argue that this ostensibly straightforward issue of translation actually raises broader issues about the intelligibility of the androginos within language and law. As the rabbis debate the status of the androginos within gendered rabbinic law, they lay out conflicting strategies for managing the androginos, including suggesting that gender variance is ultimately unassimilable under the law. In the process, they both establish the centrality of gender to rabbinic law and obliquely sketch out a category of the human in rabbinic law. Noting that this category of the human is accompanied by a discussion of violence to the androginos, I explore some of the costs of the category of the human and unintelligibility under the law for gender variant bodies.
Mapping the Territory
Authors: Dame Avery Phelan 
Published: December 2016

AbstractRecent work on Internet discourse focuses extensively on social network sites, which now serve as the primary organizing location for trans individuals. Yet despite their declining popularity, stand-alone websites—often continuously maintained by a single owner—continue to serve as important resources for online information and discourse. This essay, first, locates the website within the history of transgender online publics and, second, considers their current complex position in the trans media landscape. In part, they serve as an accessible, living archive of English-language trans experience, tracking the evolution of web design aesthetics, community composition, and trans terminology. Yet sites’ temporal contexts—key to their archival status—are obscured when they are called up by search engines. The opacity of search algorithms’ indexing practices and their subsequent filtering of search results, then, point to the importance for new media scholars of accounting for platforms’ affordances and constraints.
Fractionated stereotactic radiation therapy for brain metastases: a systematic review with tumour control probability modelling
Authors: Baliga Sujith , Garg Madhur K , Fox Jana , Kalnicki Shalom , Lasala Patrick A , Welch Mary R , Tomé Wolfgang A , Ohri Nitin 
Published: December 2016

Objective:
Fractionated stereotactic radiotherapy (FSRT) is a relatively new option for the treatment of brain metastases. We performed a quantitative systematic review to determine if local control (LC) following is affected by FSRT dosing regimen.

Methods:
We reviewed articles describing LC following FSRT for brain metastases. LC data from each study were extracted from actuarial survival curves and aggregated to form a single data set. LC curves were generated using the Kaplan–Meier method. Log-rank testing and Cox proportional hazards modelling were utilized to test for associations between the biologically effective dose (BED) and LC. Tumour control probability modelling was performed to illustrate the relationship between the BED and the likelihood of LC after FSRT.

Results:
10 studies (720 metastases) met inclusion criteria. Prescription doses ranged from 18 to 42 Gy, delivered in 3–12 fractions (BED range: 29–100 Gy10). 1- and 2-year actuarial LC rates were 80% and 69%, respectively. Increasing BED was associated with improved LC (HR = 0.77 per increase of 10 Gy10, p = 0.009). Tumour control probability models demonstrated that the BEDs of 40, 50 and 60 Gy10 yield predicted 1-year LC rates of 73%, 78% and 84%, respectively. The BEDs of 40, 50 and 60 Gy10 yield 2-year LC rates of 62%, 69% and 81%, respectively.

Conclusion:
FSRT provides high rates of LC for patients with brain metastases. We found evidence for a dose–response relationship that should be explored in prospective trials.

Advances in knowledge:
This review identified a dose–response relationship for LC in patients treated with FSRT for brain metastases.
Incidental findings in the skeletal musculature on computed tomography
Authors: Schramm Dominik , Justus Annkathrin , Bach Andreas G , Surov Alexey 
Published: December 2016

Objective:
The purpose of this study was to analyze intramuscular incidental findings identified on CT in a large patient cohort.

Methods:
In the time period from 2010 to 2015, a total of 44,794 patients with several diagnoses were investigated by CT. Only those patients who underwent body CT including the neck, thorax, abdomen and pelvic regions after the i.v. application of a contrast medium were involved in the study. There were 4085 patients. On further analysis, only patients with intramuscular findings (IFs) incidentally detected on CT were included. Osseous or soft-tissue lesions with invasion into the musculature were excluded from the study. Patients with known or clinically suspicious muscle disorders were also excluded. Overall, 639 (15.64% of the 4085 analyzed cases) patients, 253 females and 386 males, with mean age 72.43 ± 12.02 years, were identified. Collected data were evaluated by means of descriptive statistics.

Results:
In the 639 patients, 917 IFs were identified. More often, several benign disorders were diagnosed (n = 803, 87.6%). There were hernias (33.5%), atrophy of different muscles (22%), lipomas (21%), intramuscular calcifications (8.7%), bursitis (1.2%) and intramuscular bleeding (1.1%). Malignant IFs (n = 114, 12.4%) included intramuscular metastases (11.9%) and lymphomas (0.6%). Most frequently, the identified IFs were localized in the abdominal wall musculature, paravertebral and gluteal muscles. In 657 cases (71.6% of all IFs), the identified muscle findings were not diagnosed by the radiologist who initially assessed the investigation.

Conclusion:
CT can detect different incidental disorders within the skeletal musculature. Most of them were benign. However, malignant lesions can also occur. Therefore, skeletal muscles should be carefully evaluated on CT performed for other reasons.

Advances in knowledge:
IFs occur in 15.6% of CT investigations. Benign findings represent 87.6% and malignant lesions can be identified in 12.4%.
Integration of EGA secure data access into Galaxy
Authors: Hoogstrate Youri , Zhang Chao , Senf Alexander , Bijlard Jochem , Hiltemann Saskia , van Enckevort David , Repo Susanna , Heringa Jaap , Jenster Guido , Fijneman Remond J.A. , Boiten Jan-Willem , A. Meijer Gerrit , Stubbs Andrew , Rambla Jordi , Spalding Dylan , Abeln Sanne 
Published: December 2016

High-throughput molecular profiling techniques are routinely generating vast amounts of data for translational medicine studies. Secure access controlled systems are needed to manage, store, transfer and distribute these data due to its personally identifiable nature. The European Genome-phenome Archive (EGA) was created to facilitate access and management to long-term archival of bio-molecular data. Each data provider is responsible for ensuring a Data Access Committee is in place to grant access to data stored in the EGA. Moreover, the transfer of data during upload and download is encrypted. ELIXIR, a European research infrastructure for life-science data, initiated a project (2016 Human Data Implementation Study) to understand and document the ELIXIR requirements for secure management of controlled-access data. As part of this project, a full ecosystem was designed to connect archived raw experimental molecular profiling data with interpreted data and the computational workflows, using the CTMM Translational Research IT (CTMM-TraIT) infrastructure http://www.ctmm-trait.nl as an example. Here we present the first outcomes of this project, a framework to enable the download of EGA data to a Galaxy server in a secure way. Galaxy provides an intuitive user interface for molecular biologists and bioinformaticians to run and design data analysis workflows. More specifically, we developed a tool -- ega_download_streamer - that can download data securely from EGA into a Galaxy server, which can subsequently be further processed. This tool will allow a user within the browser to run an entire analysis containing sensitive data from EGA, and to make this analysis available for other researchers in a reproducible manner, as shown with a proof of concept study. The tool ega_download_streamer is available in the Galaxy tool shed: https://toolshed.g2.bx.psu.edu/view/yhoogstrate/ega_download_streamer.
Mohs wounds of the forehead: healing by secondary intention
Authors: Becker G.D. , Adams L.A. , Levin B.C. 
Published: December 2016

Accurate prediction of the course of wound healing allows patients with Mohs surgical wounds on the face to be objectively selected either for surgical repair or for spontaneous healing. Parameters affecting wound healing - location, depth and size of wound - were documented at intervals for 135 patients who had full-thickness defects in the forehead after Mohs surgery, which were left to heal by secondary intention. Quality of cosmesis was determined at least four months after surgery. Final cosmetic result was predictable on the basis of wound location, size and depth. Allowing selected Mohs surgical wounds to heal spontaneously offers optimal cancer surveillance, simplified wound care and elimination of reconstructive procedures along with their associated costs and potential complications.
Stay on the ambulance long enough and you'll go full circle: an evaluation of the clinical safety and effectiveness of non-emergency and multi-occupancy ambulance conveyance in non-emergency percutaneous coronary intervention patients
Authors: Scholes Steven , Tunn Eddie , Newton Mark , Ratcliffe David 
Published: December 2016

Mechanisms to facilitate rapid ambulance transport of diagnosed STEMI patients from the community and emergency departments (ED) settings directly to primary percutaneous coronary intervention (PPCI) facilities are well established within NHS Ambulance Services. Direct challenge of inter-hospital transfer requests for non-emergency percutaneous coronary intervention (PCI) patients by a regional NHS Ambulance Service identified disagreement between peripheral feeder hospitals and the NHS Ambulance Service on what level of ambulance transport is most appropriate. To reduce unnecessary peripheral feeder hospital requests for paramedic emergency service transfer and resource utilisation in non-emergency PCI patients and to assess the clinical safety of both non-emergency transport and multi-occupancy conveyance for this patient group. A process was established with a regional cardiothoracic centre to support pre-screening of non-emergency PCI patients for conveyance via non-emergency ambulance resources and multi-occupancy. This included centralisation of all non-emergency PCI ambulance transport booking practices and dissemination of learning materials on the process to all stakeholders. During the three-year period 3172 patients were identified as suitable for conveyance by both non-emergency ambulance transports. Of this, 36% (n=1767) were conveyed as part of a multi-occupancy journey and 56% (n=782) were conveyed by non-emergency resources. Overall, 69% (n=782) of all multi-occupancy conveyances were undertaken by non-emergency resources. Two clinical incidents were noted during this period, both of which were managed via clinical telephone advice. Non-emergency ambulances can be safely used to transport non-emergency PCI patients via multi-occupancy, following appropriate pre-screening by the receiving PCI unit. Further work is needed to understand the feasibility of this across other patient groups in the inter-hospital transfer scenario and its transferability to other NHS Ambulance Services.
Football referees; stress, self-confidence, decision making<p>Futbol hakemlerinde; stres, özgüven, karar verme
Authors: Baştuğ Gülsüm 
Published: December 2016

Football, is a universal sport with most audiences all around the world. Considering footballers, managers, trainers, audiences involved in football sector referees’ emotional situations, life stress, decision making skills have become important in football environment. The aim of the study was to analyse stress, self-confidence and decision-making skills in football referees. In the study 145 football referees having an age average of 25.88 ± 4.24 participated. In order to determine football referees’ stress levels, “Perceived Stress Scale” developed by Cohen, Kamarck and Mermelstein (1983) and to find out decision-making skills, “Melbourne Decision-Making Scale I-II” developed by Mann et al. (1998) were applied. In evaluation of data Pearson correlation test and Independent t test were done.As a result; significant relations were found between stress, self-confidence and decision-making in football referees. A significant relation was determined between football referees’ self-confidence and decision-making skills. In football referees a meaningful difference was also found between stress level and gender variable. It is apparent that the female football referees’ stress perceptions were higher rather than the male football referees. ÖzetFutbol, dünyada da en fazla seyircisi olan evrensel bir spordur. Futbol sektörü içinde bulunan futbolcu, yönetici, çalıştırıcı, seyirciler düşünüldüğünde hakemlerin futbol ortamı içinde duygu durumları, yaşadığı stres, karar verme becerisi de önemli hale gelmektedir. Bu çalışmanın amacı, futbol hakemlerinde stres, özgüven ve karar verme becerisini incelemektir. Araştırmaya yaş ortalaması 25.88 ± 4.24 olan 145 futbol hakemi katılmıştır. Futbol hakemlerinin stres düzeylerini belirlemek için Cohen, Kamarck ve Mermelstein (1983) tarafından geliştirilen “Algılanan Stres Ölçeği” ile karar verme becerilerini belirlemek için Mann ve diğerleri (1998) tarafından geliştirilen “Melbourne karar verme ölçeği I-II” uygulanmıştır. Verilerin değerlendirilmesinde Pearson korelasyon testi ve Bağımsız t testi yapılmıştır.Sonuç olarak; Futbol hakemlerinde stres ile özgüven ve karar verme arasında anlamlı ilişki bulunmuştur. Hakemlerin özgüven ile karar verme becerisi arasında anlamlı ilişki tespit edilmiştir. Futbol hakemlerinde stres düzeyi ile cinsiyet değişkeni arasında anlamlı farklılık bulunmuştur. Kadın futbol hakemlerinin stres algılarının erkek hakemlerden yüksek olması dikkat çekicidir.
Antioxidant effectiveness of dehydrogenated p-phenylene diamines through NMR calculations
Authors: Puškárová Ingrid , Breza Martin 
Published: December 2016

Abstract
NMR shifts of N-phenyl-N’-alkyl-p-phenylenediamines (PPD) in vacuum were evaluated by B3LYP calculations using GIAO method. According to our previous studies, the Molar Antioxidant Effectiveness (AEM) of PPD antioxidants correlates with NMR chemical shifts of the amine nitrogen between aromatic rings (NA), the side aliphatic chain nitrogen (NB) and its neighboring tertiary carbon atom (CT) as well as of the hydrogens bonded to them. Our results indicate that the above mentioned chemical shifts correlate with increasing reactivity of dehydrogenated PPD antioxidants at these sites as well.
Determination of enantiomeric composition of fluoxetine by synchronous fluorescence spectrometry coupled with multivariate calibration in biological samples
Authors: Poláček Roman , Májek Pavel , Sádecká Jana 
Published: December 2016

AbstractThis paper presents rapid and low cost analytical method for the determination of the fluoxetine enantiomeric composition in biological samples (urine). The combination of synchronous fluorescence spectrometry and inverse multivariate calibration methods was used. The chiral recognition of the fluoxetine was based on the creating of the diastereomeric complexes withβ-cyclodextrin. A net analytical signal of diastereomeric complexes was obtained by the addition of aliquot part of urine into calibration and validation sets. This step ensures the elimination of the urine matrix effect. The synchronous fluorescence spectra at the constant wavelength differences (Δλ) of 30 and 50 nm, based on RMS %RE values, were chosen for chemometric analysis. Principal component regression (PCR) and partial least square method (PLS) were compared to determine the enantiomeric composition. The most suitable results were provided by the PLS model constructed from the synchronous data at Δλ = 50 nm. The calculated figure of merit was used for validation of proposed method.