bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mass Transfer Parameters and Modeling of Hot Air Drying Kinetics of Dill Leaves
Authors: Darvishi Hosain , Farhudi Zanyar , Behroozi-Khazaei Nasser 
Published: November 2016

Abstract
Moisture diffusivity (Dem), mass transfer coefficient (hm), activation energy and drying kinetics of the dill leaves were studied and modeled as a function of temperature (40–70 °C) and moisture content (0.20–5.67 kg water/kg dry matter). Results showed that the Dem and hm significantly depend on the temperature and moisture content (p < 0.05). The average of Dem and hm varied between 4.02 × 10–9 to 9.65 × 10–9 m2/s, and 2.38 × 10–7 to 6.33 × 10–7 m/s, respectively. Activation energy showed a significant dependence on the moisture content and estimated as 16.84 kJ/mol for diffusion model and 28.70 kJ/mol for mass transfer model. Out of the six models considered, the logarithmic model showed the best fit to drying behavior of the dill leaves.
The Uniqueness of Planktonic Ecosystems in the Mediterranean Sea: The Response to Orbital- and Suborbital-Climatic Forcing over the Last 130,000 Years
Authors: Incarbona Alessandro , Di Stefano Enrico , Sprovieri Rodolfo , Ferraro Serena 
Published: November 2016

AbstractThe Mediterranean Sea is an ideal location to test the response of organisms to hydrological transformations driven by climate change. Here we review studies carried out on planktonic foraminifera and coccolithophores during the late Quaternary and attempt the comparison of data scattered in time and space. We highlight the prompt response of surface water ecosystems to both orbital- and suborbital-climatic variations.A markedly different spatial response was observed in calcareous plankton assemblages, possibly due to the influence of the North Atlantic climatic system in the western, central and northern areas and of the monsoon system in the easternmost and southern sites. Orbital-induced climatic dynamics led to productive surface waters in the northern, western and central Mediterranean Sea during the last glacial and to distinct deep chlorophyll maximum layers in the eastern Mediterranean Sea coinciding with bottom anoxia episodes. High-frequency planktonic modifications are well documented in the Sicily Channel and Alboran Sea and highlight the occurrence of different steps within a single stadial (cold phase)/interstadial (warm phase) oscillation.The review of planktonic organisms in the marine sedimentary archive casts light on the uniqueness of the Mediterranean Sea, especially in terms of climatic/oceanographic/biological interaction and influence of different climatic systems on distinct areas. Further research is needed in the eastern Mediterranean Sea where results are obscured by low-resolution sedimentary records and by a strong focus on sapropel deposition dynamics.
Successful transition to sulfonylurea therapy in two Iraqi siblings with neonatal diabetes mellitus and iDEND syndrome due to ABCC8 mutation
Authors: Ozsu Elif , Giri Dinesh , Seymen Karabulut Gulcan , Senniappan Senthil 
Published: November 2016

Abstract
Neonatal diabetes is a rare form of monogenic diabetes characterised by persistent hyperglycaemia during the first 6–9 months of age. About half of the cases of neonatal diabetes are transient forms resulting from mutations in the genes in the imprinted region of chromosome 6q24 and the other half are permanent forms. Activating mutations in the potassium ATP (K
Maxillary fibrous dysplasia associated with McCune-Albright syndrome. A case study
Authors: Wójcik Sylwia , Koszowski Rafał , Drozdowska Bogna , Śmieszek-Wilczewska Joanna , Raczkowska-Siostrzonek Agnieszka 
Published: November 2016

Abstract
McCune Albright syndrome (MCA) is a rare complication of genetic origin. The authors present a case study of a patient with MCA diagnosed with multifocal fibrous dysplasia in his limb and craniofacial bones. The symptoms of the disease in the patient’s facial and oral tissue and the treatment administered have been described.
Crystal structure of 2-[3,5-bis(trifluoromethyl)benzylsulfanyl]-5-(5-bromothiophen-2-yl)-1,3,4-oxadiazole, C15H7BrF6N2OS2
Authors: Al-Omary Fatmah A. M. , Alanazi Fahdah S. , Ghabbour Hazem A. , El-Emam Ali A. 
Published: November 2016

Abstract
C15H7BrF6N2OS2, monoclinic, P21/c (no. 14), a = 18.8292(14) Å, b = 11.4568(9) Å, c = 8.3400(6) Å, β = 90.791(3)°, V = 1799.0(2) Å3, Z = 4, R
gt(F) = 0.068, wR
ref(F
2) = 0.199, T = 296(2).
Killing for the Sake of Infamy: The Herostratos Syndrome and what to Do about it
Authors: Azam Jean-Paul , Ferrero Mario 
Published: November 2016

Abstract
The Herostratos syndrome affects some people who perpetrate odious attacks for the sake of infamy. We suggest that this sheds some useful light to explain the wave of mass killing going on in Europe and North America, including school shootings and Jihadist terrorism, within a game-theoretic framework. The analysis points out that policies aimed at countering this type of violence should focus on trivializing these attacks and reducing the publicity that they get in the media.
Sulla cronologia di Orazio, Odi I–III (prima parte)
Authors: Biddau Federico 
Published: November 2016

Abstract
The theory that the first three books of Horace’s Odes were published together is based on arguments which do not stand up to open-minded analysis (§§ 2–3). In particular, the dating of the individual odes, in the few cases that can be established with any sound grounds, far from corroborating this theory rather reveals that three periods can be distinguished quite well for the composition of the three books (§ 3.3). Various elements, notable among them certain consistent evolutions in the metre, demonstrate that the books were in fact composed in series, and various findings of a historical nature provide confirmation of the composition-periods already detected (§§ 4.1–3). The Roman odes, however, demand different years, and their composition, completed at the time of Book III, had already begun and had progressed at least at the time of Book II (§ 4.1.3). Given these results, the hypothesis that the three books were published separately and in sequence is the most economical, best reflects Horace’s habits, and explains or eliminates some anomalies, but it is also supported by various specific indications (§ 4.4–6). We may conclude that Odes I, II and III appeared, respectively, at the end of AD 28, during 25, and in 23 or 22.
Towards Reliable Velocities of Permanent GNSS Stations
Authors: Bogusz Janusz , Klos Anna , Gruszczynska Marta , Gruszczynski Maciej 
Published: November 2016

Abstract
In the modern geodesy the role of the permanent station is growing constantly. The proper treatment of the time series from such station lead to the determination of the reliable velocities. In this paper we focused on some pre-analysis as well as analysis issues, which have to be performed upon the time series of the North, East and Up components and showed the best, in our opinion, methods of determination of periodicities (by means of Singular Spectrum Analysis) and spatio-temporal correlations (Principal Component Analysis), that still exist in the time series despite modelling. Finally, the velocities of the selected European permanent stations with the associated errors determined following power-law assumption in the stochastic part is presented.
A Webgis Framework for Disseminating Processed Remotely Sensed on Land Cover Transformations
Authors: Caradonna Grazia , Novelli Antonio , Tarantino Eufemia , Cefalo Raffaela , Fratino Umberto 
Published: November 2016

Abstract
Mediterranean regions have experienced significant soil degradation over the past decades. In this context, careful land observation using satellite data is crucial for understanding the long-term usage patterns of natural resources and facilitating their sustainable management to monitor and evaluate the potential degradation. Given the environmental and political interest on this problem, there is urgent need for a centralized repository and mechanism to share geospatial data, information and maps of land change. Geospatial data collecting is one of the most important task for many users because there are significant barriers in accessing and using data. This limit could be overcome by implementing a WebGIS through a combination of existing free and open source software for geographic information systems (FOSS4G).
In this paper we preliminary discuss methods for collecting raster data in a geodatabase by processing open multi-temporal and multi-scale satellite data aimed at retrieving indicators for land degradation phenomenon (i.e. land cover/land use analysis, vegetation indices, trend analysis, etc.). Then we describe a methodology for designing a WebGIS framework in order to disseminate information through maps for territory monitoring. Basic WebGIS functions were extended with the help of POSTGIS database and OpenLayers libraries. Geoserver was customized to set up and enhance the website functions developing various advanced queries using PostgreSQL and innovative tools to carry out efficiently multi-layer overlay analysis. The end-product is a simple system that provides the opportunity not only to consult interactively but also download processed remote sensing data.
Implementation of Satellite Techniques in the Air Transport
Authors: Fellner Andrzej , Jafernik Henryk 
Published: November 2016

Abstract
The article shows process of the implementation satellite systems in Polish aviation which contributed to accomplishment Performance-Based Navigation (PBN) concept. Since 1991 authors have introduced Satellite Navigation Equipment in Polish Air Forces. The studies and researches provide to the Polish Air Force alternative approaches, modernize their navigation and landing systems and achieve compatibility with systems of the North Atlantic Treaty Organization (NATO) and International Civil Aviation Organization (ICAO). Acquired experience, conducted military tests and obtained results enabled to take up work scientifically - research in the environment of the civil aviation. Therefore in 2008 there has been launched cooperation with Polish Air Navigation Services Agency (PANSA). Thanks to cooperation, there have been compiled and fulfilled three fundamental international projects: EGNOS APV MIELEC (EGNOS Introduction in European Eastern Region - APV Mielec), HEDGE (Helicopters Deploy GNSS in Europe), SHERPA (Support ad-Hoc to Eastern Region Pre-operational in GNSS). The successful completion of these projects enabled implementation 21 procedures of the RNAV GNSS final approach at Polish airports, contributing to the implementation of PBN in Poland as well as ICAO resolution A37-11. Results of conducted research which served for the implementation of satellite techniques in the air transport constitute the meaning of this material.
Complex Geodetic Research in Ukrainian Antarctic Station “Academician Vernadsky” (Years 2002 - 2005, 2013-2014)
Authors: Tretyak Kornyliy , Hlotov Volodymyr , Holubinka Yuriy , Marusazh Khrystyna 
Published: November 2016

Abstract
In this paper is given an information about complex geodetic research in Ukrainian Antarctic station “Academician Vernadsky”. Research were carried by Lviv polytechnic scientists, during Antarctic expeditions in years 2002 - 2005, 2013, 2014. Main objectives of the studies were: (a) study of the islands glaciers surface volumes changes in Antarctic archipelago and Antarctic Peninsula using terestrial laser scaning and digital terrestrial stereophotogrammetry survey; (b) investigation of Penola strain tectonic fault, using the results of precise GNSS observations.
Roles of Cbln1 in Non-Motor Functions of Mice
Authors: Otsuka Shintaro , Konno Kohtarou , Abe Manabu , Motohashi Junko , Kohda Kazuhisa , Sakimura Kenji , Watanabe Masahiko , Yuzaki Michisuke 
Published: November 2016

The cerebellum is thought to be involved in cognitive functions in addition to its well established role in motor coordination and motor learning in humans. Cerebellin 1 (Cbln1) is predominantly expressed in cerebellar granule cells and plays a crucial role in the formation and function of parallel fiber–Purkinje cell synapses. Although genes encoding Cbln1 and its postsynaptic receptor, the delta2 glutamate receptor (GluD2), are suggested to be associated with autistic-like traits and many psychiatric disorders, whether such cognitive impairments are caused by cerebellar dysfunction remains unclear. In the present study, we investigated whether and how Cbln1 signaling is involved in non-motor functions in adult mice. We show that acquisition and retention/retrieval of cued and contextual fear memory were impaired inCbln1-null mice.In situhybridization and immunohistochemical analyses revealed that Cbln1 is expressed in various extracerebellar regions, including the retrosplenial granular cortex and the hippocampus. In the hippocampus, Cbln1 immunoreactivity was present at the molecular layer of the dentate gyrus and the stratum lacunosum-moleculare without overt mRNA expression, suggesting that Cbln1 is provided by perforant path fibers. Retention/retrieval, but not acquisition, of cued and contextual fear memory was impaired in forebrain-predominantCbln1-null mice. Spatial learning in the radial arm water maze was also abrogated. In contrast, acquisition of fear memory was affected in cerebellum-predominantCbln1-null mice. These results indicate that Cbln1 in the forebrain and cerebellum mediates specific aspects of fear conditioning and spatial memory differentially and that Cbln1 signaling likely regulates motor and non-motor functions in multiple brain regions.SIGNIFICANCE STATEMENTDespites its well known role in motor coordination and motor learning, whether and how the cerebellum is involved in cognitive functions remains less clear. Cerebellin 1 (Cbln1) is highly expressed in the cerebellum and serves as an essential synaptic organizer. Although genes encoding Cbln1 and its receptor are associated with many psychiatric disorders, it remains unknown whether such cognitive impairments are caused by cerebellar dysfunction. Here, we show that Cbln1 is also expressed in the forebrain, including the hippocampus and retrosplenial granular cortex. Using forebrain- and cerebellum-predominant conditionalCbln1-null mice, we show that Cbln1 in the forebrain and cerebellum mediates specific aspects of fear conditioning and spatial memory differentially, indicating that Cbln1 signaling regulates both motor and non-motor functions in multiple brain regions.
Aging Affects Dopaminergic Neural Mechanisms of Cognitive Flexibility
Authors: Berry Anne S. , Shah Vyoma D. , Baker Suzanne L. , Vogel Jacob W. , O'Neil James P. , Janabi Mustafa , Schwimmer Henry D. , Marks Shawn M. , Jagust William J. 
Published: November 2016

Aging is accompanied by profound changes in the brain's dopamine system that affect cognitive function. Evidence of powerful individual differences in cognitive aging has sharpened focus on identifying biological factors underlying relative preservation versus vulnerability to decline. Dopamine represents a key target in these efforts. Alterations of dopamine receptors and dopamine synthesis are seen in aging, with receptors generally showing reduction and synthesis demonstrating increases. Using the PET tracer 6-[18F]fluoro-l-m-tyrosine, we found strong support for upregulated striatal dopamine synthesis capacity in healthy older adult humans free of amyloid pathology, relative to young people. We next used fMRI to define the functional impact of elevated synthesis capacity on cognitive flexibility, a core component of executive function. We found clear evidence in young adults that low levels of synthesis capacity were suboptimal, associated with diminished cognitive flexibility and altered frontoparietal activation relative to young adults with highest synthesis values. Critically, these relationships between dopamine, performance, and activation were transformed in older adults with higher synthesis capacity. Variability in synthesis capacity was related to intrinsic frontoparietal functional connectivity across groups, suggesting that striatal dopamine synthesis influences the tuning of networks underlying cognitive flexibility. Together, these findings define striatal dopamine's association with cognitive flexibility and its neural underpinnings in young adults, and reveal the alteration in dopamine-related neural processes in aging.SIGNIFICANCE STATEMENTFew studies have combined measurement of brain dopamine with examination of the neural basis of cognition in youth and aging to delineate the underlying mechanisms of these associations. Combiningin vivoPET imaging of dopamine synthesis capacity, fMRI, and a sensitive measure of cognitive flexibility, we reveal three core findings. First, we find evidence supporting older adults' capacity to upregulate dopamine synthesis. Second, we define relationships between dopamine, cognition, and frontoparietal activity in young adults indicating high levels of synthesis capacity are optimal. Third, we demonstrate alteration of these relationships in older adults, suggesting neurochemical modulation of cognitive flexibility changes with age.
Early Odorant Exposure Increases the Number of Mitral and Tufted Cells Associated with a Single Glomerulus
Authors: Liu Annie , Savya Sajishnu , Urban Nathaniel N. 
Published: November 2016

The highly specific organization of the olfactory bulb (OB) is well known, but the impact of early odorant experience on its circuit structure is unclear. Olfactory sensory neurons (OSNs) project axons from the olfactory epithelium to the OB, where they form spherical neuropil structures called glomeruli. These glomeruli and the postsynaptic targets of OSNs, including mitral and tufted cells (M/TCs) and juxtaglomerular cells, form glomerular modules, which represent the basic odor-coding units of the OB. Here, we labeled M/TCs within a single glomerular module of the mouse OB and show that odorant exposure that starts prenatally and continues through postnatal day 25 has a major impact on the structure of the glomerular module. We confirm that exposure increases the volume of the activated glomeruli and show that exposure increases M/TC number by >40% in a glomerulus-specific fashion. Given the role of M/TCs in OB output and in lateral inhibition, increasing the number of M/TCs connected to a single glomerulus may also increase the influence of that glomerulus on the OB network and on OB output. Our results show that early odorant exposure has a profound effect on OB connectivity and thus may affect odorant processing significantly.SIGNIFICANCE STATEMENTExperience shapes neural circuits in a variety of ways, most commonly by changing the strength of activated connections. Relatively little is known about how experience changes circuitry in the olfactory system. Here, we show that for a genetically identified glomerulus in the mouse olfactory bulb, early odorant exposure increases the number of associated mitral and tufted cells by 40% and 100%, respectively. Understanding the structural changes induced by early odorant experience can provide insight into how bulbar organization gives rise to efficient processing. We find that odorant experience increases the number of projection neurons associated with a single glomerulus significantly, a dramatic and long-lasting structural change that may have important functional implications.
Activity-Dependent Dynamics of the Transcription Factor of cAMP-Response Element Binding Protein in Cortical Neurons Revealed by Single-Molecule Imaging
Authors: Kitagawa Hironobu , Sugo Noriyuki , Morimatsu Masatoshi , Arai Yoshiyuki , Yanagida Toshio , Yamamoto Nobuhiko 
Published: November 2016

Transcriptional regulation is crucial for neuronal activity-dependent processes that govern neuronal circuit formation and synaptic plasticity. An intriguing question is how neuronal activity influences the spatiotemporal interactions between transcription factors and their target sites. Here, using a single-molecule imaging technique, we investigated the activity dependence of DNA binding and dissociation events of cAMP-response element binding protein (CREB), a principal factor in activity-dependent transcription, in mouse cortical neurons. To visualize CREB at the single-molecule level, fluorescent-tagged CREB in living dissociated cortical neurons was observed by highly inclined and laminated optical sheet microscopy. We found that a significant fraction of CREB spots resided in the restricted locations in the nucleus for several seconds (dissociation rate constant: 0.42 s−1). In contrast, two mutant CREBs, which cannot bind to the cAMP-response element, scarcely exhibited long-term residence. To test the possibility that CREB dynamics depends on neuronal activity, pharmacological treatments and an optogenetic method involving channelrhodopsin-2 were applied to cultured cortical neurons. Increased neuronal activity did not appear to influence the residence time of CREB spots, but markedly increased the number of restricted locations (hot spots) where CREB spots frequently resided with long residence times (>1 s). These results suggest that neuronal activity promotes CREB-dependent transcription by increasing the frequency of CREB binding to highly localized genome locations.SIGNIFICANCE STATEMENTThe transcription factor, cAMP response element-binding protein (CREB) is known to regulate gene expression in neuronal activity-dependent processes. However, its spatiotemporal interactions with the genome remain unknown. Single-molecule imaging in cortical neurons revealed that fluorescent-tagged CREB spots frequently reside at fixed nuclear locations in the time range of several seconds. Neuronal activity had little effect on the CREB residence time, but increased the rapid and frequent reappearance of long-residence CREB spots at the same nuclear locations. Thus, activity-dependent transcription is attributable to frequent binding of CREB to specific genome loci.