bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sindrom Kartagener pada perempuan dewasa: sebuah laporan kasus langka
Authors: Ida Ayu Devi Ariani , Widyaningsih Putu Dyah 
Published: September 2024

Background: Kartagener’s syndrome, a rare autosomal recessive genetic cilia disorder, is a triad condition consisting of situs inversus, chronic sinusitis, and bronchiectasis. Kartagener’s syndrome has caused a frequency of 1 in 30,000–40,000 live births. This case report aims to present a 28-year-old female with Kartagener syndrome.
Case presentation: A 28-year-old female with chief complaints of coughing, runny nose, and dyspnea that had been occurring for the previous two months. The patient underwent surgery for sinusitis. The patient's biological father has a history of asthma, according to the patient's family history. On clinical and radiographic evaluation, situs inversus, bronchiectasis, and chronic sinusitis were found. Patient was treated with oral antibiotics, inhaled bronchodilators, mucolytics, oral capsules containing corticosteroids, antihistamines, and bronchodilators, sprays of corticosteroids, isotonic fluids, sinus irrigation, and polypectomy. The patient's prognosis was dubia ad malam.
Conclusion: Patient with Kartagener syndrome often present with persistent, recurrent sinopulmonary symptoms due to inadequate mucociliary clearance, patients. Primary objectives of patient therapy are preventing the course of the disease, preserving lung function, and improving the patient's quality of life.

Latar belakang: Sindrom Kartagener adalah kelainan silia genetik resesif autosomal langka yang terdiri dari trias (situs inversus, sinusitis kronis, dan bronkiektasis). Sindrom Kartagener merupakan subkelompok Diskinesia Silia Primer dengan insiden 1 dari 30.000-40.000 kelahiran hidup. Struktur atau fungsi silia yang abnormal menyebabkan gangguan motilitas Silia. Diagnosis dini pada awal kehidupan sangat penting untuk mencegah komplikasi dan meningkatkan kualitas hidup.
Presentasi kasus: Seorang wanita berusia 28 tahun dengan keluhan utama batuk, pilek, dan sesak napas yang terjadi sejak dua bulan sebelumnya. pasien menjalani operasi untuk sinusitis. Ayah kandung pasien mempunyai riwayat penyakit asma, sesuai dengan riwayat keluarga pasien. Pada evaluasi klinis dan radiografi ditemukan situs inversus, bronkiektasis, dan sinusitis kronis. Pasien diterapi dengan antibiotik oral, bronkodilator inhalasi, mukolitik, kapsul oral yang mengandung kortikosteroid, antihistamin, dan bronkodilator, semprotan kortikosteroid, cairan isotonik, irigasi sinus, dan polipektomi. Prognosis pasien adalah dubia ad malam.
Simpulan: Pasien dengan sindrom Kartagener sering mengalami gejala sinopulmoner yang persisten dan berulang karena klirens mukosiliar yang tidak cukup. Tujuan utama terapi yaitu mencegah perjalanan penyakit, menjaga fungsi paru-paru, dan meningkatkan kualitas hidup pasien.
Hybrid halide perovskites, a game changer for future solar energy?
Authors: Faini Fabiola , Larini Valentina , Scardina Alice , Grancini Giulia 
Published: September 2024

AbstractHybrid halide perovskites (HPs) are emerging as the most promising materials for near-future photovoltaics (PV) due to their unique optoelectronic properties, such as their low defect density and broad absorption, making them highly efficient photoactive materials. Meanwhile, their low cost and low embodied energy, together with their solution processability and the possibility to create solar cells on flexible substrates, make them among the potential winning concepts for the next-generation PV market. Large-scale marketing, however, requires solving current challenges, which mainly relate to device longevity and scaling up. In this article, we put in perspective the key aspects of HP materials and HP-solar cells, briefly discussing their historical path to high efficiency, reviewing the state of the art, presenting their main advantages over existing technologies, and the main challenges the research community needs to overcome. Recent achievements and hot areas today critical for market uptake will be presented.
Graphical abstract
The Hydrological Impact of Historical and Modern Earthquakes in Central-Southern Italy: Data Analysis and Seismotectonic Insights
Authors: Cucci Luigi , Tertulliani Andrea , Castellano Corrado 
Published: September 2024

Abstract
We present the results of research conducted on the hydrological effects induced by historical and modern earthquakes in the central-southern Apennines of Italy. We investigated thirty-nine seismic events of magnitude between M 4.1 and 7.1 that occurred between 1688 and 2020. We collected 526 observations of coseismic and postseismic hydrological effects such as increase or decrease in streamflow, variations in the water levels in wells, formation and/or disappearance of springs and changes in their discharge, and changes in the chemical and physical characteristics of waters. More than half of the observations were new data unpublished to date in the scientific literature. We find that the ease of finding data of interest is strongly influenced by the historical period in which the seismic event occurred. We summarize the methodology of data retrieval and its classification and present examples and maps of coseismic hydrological changes associated with individual seismic events. Most of our novel data derive from seismic postcards, macroseismic questionnaires, and hydrographic annals. However, a nonnegligible set of data comes from a careful rereading of sources—both historical and modern—that were at first considered fruitless. The majority of data concerns an excess flow in streams and springs, and physical–chemical variations such as turbidity, an increase in temperature, and gas emission. We also find that the maximum distance to which seismically induced streamflow responses have been reported can be related to the earthquake magnitude and use this distance to derive an alternative magnitude for some of the strongest earthquakes of our dataset. Finally, we show a potential application of this type of research because the distribution of coseismic hydrological changes can provide constraints in discriminating between the causative faults of strong historical seismic events for which the instrumental data are scarce or not available.
Physiological changes in shrub species due to different sources of dust pollution in an urban environment
Authors: Tian Yuan , Li haimei , Li Mingyan , Li Shimei , Guo Xiao 
Published: September 2024

Abstract

Plants effectively filter ambient air by adsorbing particulate matter. The correct selection of landscape plants can exert greater dust retention benefits in different polluted areas. However, few studies have focused on the dust retention ability and related physiological responses of plants under continuous dust pollution from different dust sources. Here, we assessed the particle retention dynamics and plant physiology( chlorophyll content, soluble protein content, soluble sugar content, and peroxidase activity) of six shrubs (Berberis thunbergii var. atropurpurea, Ligustrum vicaryi, Rosa multiflora, Sorbaria sorbifolia, Swida alba, and Syzyga oblata) under continuous dust pollution from different dust sources ( Industrial sources: area below the direction of the coal-fired thermal power plant in Chengyang District, Qingdao, China; Traffic sources: both sides of the road in each direction at the intersection of Great Wall Road and Zhengyang Road, Chengyang District, Qingdao, China; Clean sources: Qingdao Agricultural University Campus, Qingdao Olympic Sculpture Park). The results showed that R. multiflora had the highest dust retention per unit leaf area of 3.27 ± 0.018 g·m− 2 and 2.886 ± 0.02 g·m− 2 in the experimental treatments of fuel source dust and clean source dust, respectively. The chlorophyll content of the tested shrubs significantly decreased due to the influence of dust treatment time, the range of cellular osmoregulatory substances (soluble sugars, soluble proteins, proline) tended to first increase and then decrease, and the antioxidant enzyme activities (superoxide dismutase, peroxidase) tended to increase and then decrease after continuous dust treatment. The greatest physiological changes were observed in plants within the industrial dust treatment area. The peroxidase activity and chlorophyll could be used as sensitive indicators of dust pollution in plants. R. multiflora showed better resistance to dust and had a greater dust retention capacity than other shrubs, making it more suitable for planting as a greening tree in industrial and traffic-polluted areas. S. alba and S. sorbifolia are sensitive to dust pollution, so they can be used as sensitive tree species to indicate atmospheric dust pollution. Our results may help design a feasible approach for urban shrub greening.
The Impact of Rural Industry Integration on Rural Carbon Emissions from Provincial Data in China
Authors: Wang Xianning , Zhou Huiyan , Tian Longkun , Huang Xikai 
Published: September 2024

Abstract

This paper quantifies the impact of rural industrial integration(RII) on rural carbon emissions(RCE) in China's provinces. Firstly, collected literature to discover the intrinsic relationship between RII and RCE and selected five indicators based on the Technique for Order Preference by Similarity to an Ideal Solution(TOPSIS) method to measure the level of RII.Secondly, based on the panel data of 30 provinces (autonomous regions and municipalities) in China from 2009 to 2022, uses the spatial Durbin model(SDM)to quantify the spatial benefits of RII and RCE.Thirdly, through empirical analysis, the main findings of this paper include: (1) The level of RII increases with the year, and the TOPSIS score is higher.(2) Use the spatial Durbin model to better explain the spatial relationship between RII and RCE. Among them, RII has a significant positive effect on local RCE, while the spillover benefit on rural carbon emissions in neighboring areas is not significant, showing a positive contribution to the total effect.（3）From the spatial level, explain the control variables of regional fiscal tax revenues(RTL), urban-rural income gap(RUP), rural population development scale(RP), education level(EL), and forest cover rate(FCR) on the significant role of RCE, reflecting the impact of regional differentiation, and introduce the lag term of spatial variables to improve the fit and explanatory ability of the model.（4）This paper provides robustness and Endogenous tests to improve the explainability of the model.Finally, based on the above findings, policy makers can propose optimized policies and safeguard measures from the aspects of industrial integration mechanism, green and low-carbon development path, agricultural science and technology support, and carbon trading of agricultural enterprises.
Hypoxic mesenchymal stem cell-derived exosomal circDennd2a regulates granulosa cell glycolysis by interacting with LDHA
Authors: Li Wenxin , Lu Minjun , Shang Junyu , Zhou Jiamin , Lin Li , Liu Yueqin , Zhao Dan , Zhu Xiaolan 
Published: September 2024

Abstract

Background
Premature ovarian insufficiency (POI) is an ovarian dysfunction disorder that significantly impacts female fertility. Ovarian granulosa cells (GCs) are crucial somatic components supporting oocyte development that rely on glycolysis for energy production, which is essential for follicular growth. Hypoxia-induced exosomal circRNAs regulate glycolysis, but their biological functions and molecular mechanisms in POI are largely unexplored. The present comprehensive investigation revealed a substantial reduction in ovarian glycolysis levels in POI rats. Notably, hypoxia-induced exosomes originating from mesenchymal stem cells (HM-Exs) exhibit a remarkable capacity to enhance ovarian glycolysis, mitigate GCs apoptosis, reinstate disrupted estrous cycles, modulate sex hormone levels, and curtail the presence of atretic follicles. These restorative actions collectively contribute to fostering fertility revival in POI-afflicted rats.
Methods
Cyclophosphamide was administered for 2 weeks to induce POI rat model, and POI rats were randomly divided into two groups and treated with NM-Exs and HM-Exs, respectively. Ovarian function and fertility were assessed at the end of the study and ovarian tissues were collected for analysis of energy metabolites. The relationship between circDennd2a and POI was explored in vitro by qRT-PCR, Western blotting, CCK-8 assay, EdU staining, TUNEL staining, extracellular acidification rate (ECAR) measurements, and ATP, lactate and pyruvate level assays.
Results
Our findings revealed depletion of circDennd2a in serum samples and GCs from individuals suffering from POI. The introduction of HM-Exs-derived circDennd2a (HM-Exs-circDennd2a) effectively counteracted GCs apoptosis by enhancing glycolytic processes and driving cellular proliferation. CircDennd2a interacted with lactate dehydrogenase A (LDHA), which served as a catalyst to increase LDHA enzymatic activity and facilitate the conversion of NADH to NAD+. This biochemical cascade worked synergistically to sustain glycolytic function within GCs.
Conclusion
This study revealed that HM-Exs-circDennd2a promoted LDHA activity and enhanced GCs glycolytic capacity, both of which support its use as a potential clinical diagnostic and therapeutic target for POI.
Multi-omics association study identifies new potential prostate cancer- causing gene
Authors: Wang Xinlong , Jiang Aimin , Shen Jiaming , Wang Lei , Liu Zhiyong 
Published: September 2024

Abstract

BACKGROUND
Prostate cancer is one of the most common malignant tumors among men worldwide, and surgery remains its mainstay of treatment. It is unclear how prostate cancer develops and what the most effective drug targets are for treating prostate cancer. Therefore, we sought to identify the genes responsible for the pathogenesis of prostate cancer.
METHODS
By integrating multidimensional and high-throughput data, proteome wide association studies (PWAS), transcriptome wide association studies (TWAS), single-cell sequencing, functional enrichment, Mendelian randomization (MR), and Bayesian co-localization analyses were used to screen for candidate genes that may contribute to prostate cancer and associate with clinical results of prostate cancer.
RESULTS
Our comprehensive analysis showed that protein abundance of eight genes was associated with prostate cancer, four of which were validated at the transcriptome level. These 8 candidate genes (MSMB, PLG, CHMP2B, ATF6B, EGF, TAPBP, GAS1 and MMP7) were validated. After combining single-cell sequencing, Mendelian randomization, and Bayesian co-localization analyses, we identified 1 gene (TAPBP) that is strongly associated with prostate cancer and explored the potential mechanisms of its pathogenicity and its clinical relevance.
Eight-Fold Increased COVID-19 Mortality in Autosomal Dominant Tubulointerstitial Kidney Disease due to MUC1 Mutations: An Observational Study
Authors: Kidd Kendrah O. , Williams Adrienne H. , Taylor Abbigail , Martin Lauren , Robins Victoria , Sayer John A. , Olinger Eric , Mabillard Holly R. , Papagregoriou Gregory , Deltas Constantinos , Stavrou Christoforos , Conlon Peter J. , Hogan Richard Edmund , Elhassan Elhussein A.E. , Springer Drahomíra , Zima Tomáš , Izzi Claudia , Vrbacká Alena , Piherová Lenka , Pohludka Michal , Radina Martin , Vylet’al Petr , Hodanova Katerina , Zivna Martina , Kmoch Stanislav , Bleyer Anthony J. 
Published: September 2024

Abstract

Background
MUC1 and UMOD pathogenic variants cause autosomal dominant tubulointerstitial kidney disease (ADTKD). MUC1 is expressed in kidney, nasal mucosa and respiratory tract, while UMOD is expressed only in kidney. Due to haplo-insufficiency ADTKD-MUC1 patients produce approximately 50% of normal mucin-1.
Methods
To determine whether decreased mucin-1 production was associated with an increased COVID-19 risk, we sent a survey to members of an ADTKD registry in September 2021, after the initial, severe wave of COVID-19. We linked results to previously obtained ADTKD genotype and plasma CA15-3 (mucin-1) levels and created a longitudinal registry of COVID-19 related deaths.
Results
Surveys were emailed to 637 individuals, with responses from 89 ADTKD-MUC1 and 132 ADTKD-UMOD individuals. 19/83 (23%) ADTKD-MUC1 survey respondents reported a prior COVID-19 infection vs. 14/125 (11%) ADTKD-UMOD respondents (odds ratio (OR) 2.35 (95%CI 1.60–3.11, P = 0.0260). Including additional familial cases reported from survey respondents, 10/41 (24%) ADTKD-MUC1 individuals died of COVID-19 vs. 1/30 (3%) with ADTKD-UMOD, with OR 9.21 (95%CI 1.22–69.32), P = 0.03. The mean plasma mucin-1 level prior to infection in 14 infected and 27 uninfected ADTKD-MUC1 individuals was 7.06 ± 4.12 vs. 10.21 ± 4.02 U/mL (P = 0.035). Over three years duration, our longitudinal registry identified 19 COVID-19 deaths in 360 ADTKD-MUC1 individuals (5%) vs. 3 deaths in 478 ADTKD-UMOD individuals (0.6%) (P = 0.0007). Multivariate logistic regression revealed the following odds ratios (95% confidence interval) for COVID-19 deaths: ADTKD-MUC1 8.4 (2.9–29.5), kidney transplant 5.5 (1.6–9.1), body mass index (kg/m2) 1.1 (1.0-1.2), age (y) 1.04 (1.0-1.1).
Conclusions
Individuals with ADTKD-MUC1 are at an eight-fold increased risk of COVID-19 mortality vs. ADTKD-UMOD individuals. Haplo-insufficient production of mucin-1 may be responsible.
Functional characteristics of plankton in relation to biophysical processes in the Indian Sector of Southern Ocean: current status of ecosystem &amp; future perspectives
Authors: A Sreerag , Mishra Rajani Kanta , Venkataramana V. , Soares Melena A. , Mohan R. 
Published: September 2024

Abstract

The plankton (phytoplankton and zooplankton) plays a major role in southern Ocean ecosystem and global climate by sinking of atmospheric carbon dioxide (CO2) and regulating biogeochemial cycle. In the study we are comparing the phytoplankton and zooplankton contributions and biomass, distinct patterns that emerge across Southern Ocean frontal zones during the austral summers of 2018 and 2020. In 2018, flagellates, particularly Gyrodinium sp., dominated carbon biomass in the Subtropical Front (STF), with contributions of 0.25 μg C/L, followed by Tripos sp., Dinophysis sp., and Protoperidinium sp. In the Subantarctic Front (SAF), Fragilariopsis sp. was prominent at 0.4 μg C/L, followed by Tripos sp. and Dinophysis sp. The Polar Front (PF), Fragilariopsis sp. significantly dominated at 1.7 μg C/L, followed by other species ranges 0.22-0.24 μg C/L. While the Southern Polar Front (SPF), Fragilariopsis sp. contributed 0.5 μg C/L. During 2020, Gyrodinium sp. became the key contributor in the STF with 1 μg C/L, followed by SAF (0.45 μg C/L), and ciliates at 0.11 μg C/L. In the PF, Fragilariopsis sp. and Thalassiosira sp. contributed at 0.6 μg C/L and 0.8 μg C/L respectively followed by Gyrodinium sp. (0.3 μg C/L). In the SPF, Fragilariopsis sp. dominated with 0.87 μg C/L followed by Gyrodinium sp. and Thalassiosira sp. The class abundance of cryptophytes dominated in the STF during 2018; however the dominance of diatom and cyanobacteria was prominent in 2020, while in SAF cryptophytes and green flagellates abundance showed a consistent. The diatoms were prevalent in the PF and SPF throughout study period, except in PF. Chlorophyll-a and other diagnostic pigments peaked contrarily across fronts and years, reflecting varying phytoplankton compositions and biomass. Zooplankton both calanoid and cyclopoid were increasing trend in PF and SPF region than STF and SAF in study period indicated their preferential food abundance of diatom biomass. On the other hand the chateognaths sp. was increased trend towards PF and SPF during 2018; whereas it decreased its trend in 2020 inferred the species with food preferential and environmental settings. Collectively, these findings underscore the dynamic relationship between phytoplankton and zooplankton communities, their shifts in distribution and abundance bases a significant role in biogeochemical cycle and climate change.
CT Coronary Fractional Flow Reserve Based on Artificial Intelligence using Different Software: A Repeatability Study
Authors: Li Jing , Yang Zhenxing , Sun Zhenting , Wang Xing , Jin Qiyu , Zhang Guoyu , Zhao Lei , Liu Aishi 
Published: September 2024

Abstract

Objective This study aims to assess the consistency of various CT-FFR software, to determine the reliability of current CT-FFR software, and to measure relevant influence factors. The goal is to build a solid foundation of enhanced workflow and technical principles that will ultimately improve the accuracy of measurements of coronary blood flow reserve fractions. This improvement is critical for assessing the level of ischemia in patients with coronary heart disease.
Methods 103 participants were chosen for a prospective research using coronary computed tomography angiography (CCTA) assessment. Heart rate, heart rate variability, subjective picture quality, objective image quality, vascular shifting length, and other factors were assessed. CT-FFR software including K software and S software are used for CT-FFR calculations. The consistency of the two software is assessed using paired-sample t-tests and Bland-Altman plots. The error classification effect is used to construct the receiver operating characteristic curve.
Results The CT-FFR measurements differed significantly between the K and S software, with a statistical significance of P < 0.05. In the Bland-Altman plot, 6% of the points (14 out of 216) fell outside the 95% consistency level. Single-factor analysis revealed that heart rate variability, vascular dislocation offset distance, subjective image quality, and lumen diameter significantly influenced the discrepancies in CT-FFR measurements between two software programs (P < 0.05). The ROC curve shows the highest AUC for the vessel shifting length, with an optimal cut-off of 0.85 mm.
Conclusion CT-FFR measurements vary among software from different manufacturers, leading to potential misclassification of qualitative diagnostics. Vessel shifting length, subjective image quality score, HRv, and lumen diameter impacted the measurement stability of various software.
Impact of the COVID-19 Pandemic on Allergy Indicators in Adults: A Retrospective Study from 2018 to 2023
Authors: Chen Junkang , Gu Yena , Yu Zhexuan , Jin Yutong , Yu Binyan , Ding Zhangkun , Xuan Lihua 
Published: September 2024

Abstract

This study aimed to assess the impact of the COVID-19 pandemic on allergy indicators in adult patients. We analyzed 8015 tIgE and 34,163 allergen detection results from 2018 to 2023. Patients were categorized into pre-pandemic (2018–2019), pandemic-period (2020–2022), and post-pandemic (2023) groups. Group comparisons and logistic regression analyses examined the relationship between relevant factors and tIgE positivity rates. Inverse probability of treatment weighting (IPTW) using propensity scores was applied to address baseline imbalances. The findings demonstrated consistent conclusions for both tIgE and allergen detection. The tIgE positivity rates and levels were significantly lower during and after the pandemic compared to the pre-pandemic period. Univariate and multivariate logistic regression analyses revealed that the pandemic and post-pandemic periods were associated with a reduced risk of tIgE positivity, with the pandemic period exhibiting a more pronounced effect. After IPTW adjustment, for tIgE, the pandemic and post-pandemic periods were associated with reduced tIgE positivity (OR = 0.436 and 0.465, respectively; P < 0.001). For tIgE related to allergen detection, the pandemic and post-pandemic periods were associated with reduced tIgE positivity (OR = 0.733 and 0.817, respectively; P < 0.001). The COVID-19 pandemic markedly enhanced allergy indicators in adults, potentially attributed to lifestyle modifications.