bluuebunny/crossref_metadata_2025_split huggingface dataset:
Change of BNP between admission and discharge after ST-elevation myocardial infarction (Killip I) improves risk prediction of heart failure, death, and recurrent myocardial infarction compared to single isolated measurement in addition to the GRACE score
Authors: Carvalho Luiz Sergio F , Bogniotti Lauro Afonso C , de Almeida Osorio Luis Rangel , e Silva Jose C Quinaglia , Nadruz Wilson , Coelho Otavio Rizzi , Sposito Andrei C 
Published: January 2018

Objective: In ST-elevation myocardial infarction, 7–15% of patients admitted as Killip I will develop symptomatic heart failure or decreased ejection fraction. However, available clinical scores do not predict the risk of severe outcomes well, such as heart failure, recurrent myocardial infarction, and sudden death in these Killip I individuals. Therefore, we evaluated whether one vs two measurements of BNP would improve prediction of adverse outcomes in addition to the GRACE score in ST-elevation myocardial infarction/Killip I individuals. Methods: Consecutive patients with ST-elevation myocardial infarction/Killip I ( n=167) were admitted and followed for 12 months. The GRACE score was calculated and plasma BNP levels were obtained in the first 12 h after symptom onset (D1) and at the fifth day (D5). Results: Fifteen percent of patients admitted as Killip I developed symptomatic heart failure and/or decreased ejection fraction in 12 months. The risk of developing symptomatic heart failure or ejection fraction <40% at 30 days was increased by 8.7-fold (95% confidence interval: 1.10–662, p=0.046) per each 100 pg/dl increase in BNP-change. Both in unadjusted and adjusted Cox-regressions, BNP-change as a continuous variable was associated with incident sudden death/myocardial infarction at 30 days (odds ratio 1.032 per each increase of 10 pg/dl, 95% confidence interval: 1.013–1.052, p<0.001), but BNP-D1 was not. The GRACE score alone showed a moderate C-statistic=0.709 ( p=0.029), but adding BNP-change improved risk discrimination (C-statistic=0.831, p=0.001). Net reclassification confirmed a significant improvement in individual risk prediction by 33.4% (95% confidence interval: 8–61%, p=0.034). However, GRACE +BNP-D1 did not improve risk reclassification at 30 days compared to GRACE ( p=0.8). At 12 months, BNP-change was strongly associated with incident sudden death/myocardial infarction, but not BNP-D1. Conclusions: Only BNP-change following myocardial infarction was associated with poorer short- and long-term outcomes. BNP-change also improves risk reclassification in addition to the GRACE score.
Does length of time spent on the waiting list for TURP influence the outcome?
Authors: Parsons Sian R , Carey Michelle M , Jenkins James ET , Davenport Kim 
Published: January 2018

With an ever increasing demand for operative procedures within the NHS but little increase in capacity, waiting lists are lengthening, particularly for benign procedures. We sought to determine whether increasing time on a waiting list influences the outcome from a transurethral resection of prostate (TURP), with a primary outcome measure of success at inpatient trial without catheter (TWOC) and pre-operative, peri-operative and post-operative secondary outcome measures. Data was collected from four separate retrospective TURP audits performed between 2009-2015. A total of 379 TURP procedures were included with the time on the waiting list ranging from 8 to 384 days. In patients who were not catheterised pre-operatively success at in patient TWOC by 30 day intervals (in 30 day intervals from 1-30 days to over 151 days) was 79%, 83%, 88%, 87%, 100% and 83%; in those with a catheter, success was 46%, 71%, 75%, 100%, 50% and 86%. In conclusion waiting longer for a TURP does not adversely affect the outcome of inpatient TWOC. Level of evidence: Not applicable – this is a single centre audit over multiple time points.
Early Chemotherapy Intensification With Escalated BEACOPP in Patients With Advanced-Stage Hodgkin Lymphoma With a Positive Interim Positron Emission Tomography/Computed Tomography Scan After Two ABVD Cycles: Long-Term Results of the GITIL/FIL HD 0607 Trial
Authors: Gallamini Andrea , Tarella Corrado , Viviani Simonetta , Rossi Andrea , Patti Caterina , Mulé Antonino , Picardi Marco , Romano Alessandra , Cantonetti Maria , La Nasa Giorgio , Trentin Livio , Bolis Silvia , Rapezzi Davide , Battistini Roberta , Gottardi Daniela , Gavarotti Paolo , Corradini Paolo , Cimminiello Michele , Schiavotto Corrado , Parvis Guido , Zanotti Roberta , Gini Guido , Ferreri Andrés J.M. , Viero Piera , Miglino Maurizio , Billio Atto , Avigdor Abraham , Biggi Alberto , Fallanca Federico , Ficola Umberto , Gregianin Michele , Chiaravalloti Agostino , Prosperini Giuseppe , Bergesio Fabrizio , Chauvie Stephane , Pavoni Chiara , Gianni Alessandro Massimo , Rambaldi Alessandro 
Published: January 2018

Purpose To investigate the progression-free survival (PFS) of patients with advanced Hodgkin lymphoma (HL) after a risk-adapted treatment strategy that was based on a positive positron emission tomography scan performed after two doxorubicin, vinblastine, vincristine, and dacarbazine (ABVD) cycles (PET2). Patients and Methods Patients with advanced-stage (IIB to IVB) HL were consecutively enrolled. After two ABVD cycles, PET2 was performed and centrally reviewed according to the Deauville five-point scale. Patients with a positive PET2 were randomly assigned to four cycles of escalated bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) followed by four cycles of standard BEACOPP with or without rituximab. Patients with a negative PET2 continued ABVD, and those with a large nodal mass at diagnosis (≥ 5 cm) in complete remission with a negative PET at the end of chemotherapy were randomly assigned to radiotherapy or no further treatment. The primary end point was 3-year PFS. Results Of 782 enrolled patients, 150 (19%) had a positive and 630 (81%) a negative PET2. The 3-year PFS of all patients was 82%. The 3-year PFS of those with a positive and negative PET2 was 60% and 87%, respectively ( P < .001). The 3-year PFS of patients with a positive PET2 assigned to BEACOPP with or without rituximab was 63% versus 57% ( P = .53). In 296 patients with both interim and post-ABVD–negative PET who had a large nodal mass at diagnosis, radiotherapy was randomly added after chemotherapy without a significant PFS improvement (97% v 93%, respectively; P = .29). The 3-year overall survival of all 782 patients was 97% (99% and 89% for PET2 negative and positive, respectively). Conclusion The PET-driven switch from ABVD to escalated BEACOPP is feasible and effective in high-risk patients with advanced-stage HL.
Hepatic metabolomic profiling changes along with postnatal liver maturation in breeder roosters
Authors: Wu Shengru , Liu Yanli , Zhu Liqin , Han Di , Bello Bodinga Musa , Yang Xiaojun 
Published: January 2018

ABSTRACT
To understand the hepatic metabolic changes during postnatal liver maturation process in breeder roosters, we investigated the hepatic metabolites composition of 1-day-old, 42-day-old, and 35-week-old breeder roosters using gas chromatography-mass spectrometer (GC-MS). Comprehensive multivariate data analyses were applied to identify the distinguishing metabolites of liver. 84 different kinds of distinguishing metabolites were identified between the livers of 1-day-old and 42-day-old breeder roosters, and 58 different kinds of distinguishing metabolites were identified between the livers from 42-day-old and 35-week-old breeder roosters. Further pathway annotations revealed that the hepatic metabolism was extensively remodeled during the postnatal liver maturation process. The antioxidant capacity of the liver and metabolism of carbohydrates, proteins, amino acids, fats, cholesterols, nucleic acids, and vitamins were all significantly changed at different growing periods after birth. Specifically, we found that the hepatic amino acid metabolic function was continuously enhanced from 1-day-old to 35-week-old roosters. However, the glucose and lipid metabolic functions were weakened from 1-day-old to 42-day-old roosters and then elevated from 42-day-old to 35-week-old roosters. In conclusion, the present study revealed that the metabolomic changes are related to the adaption of liver functions in breeder roosters.
The hematopoietic stem cell niche: from embryo to adult
Authors: Gao Xin , Xu Chunliang , Asada Noboru , Frenette Paul S. 
Published: January 2018

ABSTRACT
Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally to the bone marrow, where most HSCs reside throughout adult life. These niches provide supportive microenvironments that specify, expand and maintain HSCs. Understanding the constituents and molecular regulation of HSC niches is of considerable importance as it could shed new light on the mechanistic principles of HSC emergence and maintenance, and provide novel strategies for regenerative medicine. However, controversy exists concerning the cellular complexity of the bone marrow niche, and our understanding of the different HSC niches during development remains limited. In this Review, we summarize and discuss what is known about the heterogeneity of the HSC niches at distinct stages of their ontogeny, from the embryo to the adult bone marrow, drawing predominantly on data from mouse studies.
Podoplanin regulates mammary stem cell function and tumorigenesis by potentiating Wnt/β-catenin signaling
Authors: Bresson Laura , Faraldo Marisa M. , Di-Cicco Amandine , Quintanilla Miguel , Glukhova Marina A. , Deugnier Marie-Ange 
Published: January 2018

ABSTRACT
Stem cells (SCs) drive mammary development, giving rise postnatally to an epithelial bilayer composed of luminal and basal myoepithelial cells. Dysregulation of SCs is thought to be at the origin of certain breast cancers; however, the molecular identity of SCs and the factors regulating their function remain poorly defined. We identified the transmembrane protein podoplanin (Pdpn) as a specific marker of the basal compartment, including multipotent SCs, and found Pdpn localized at the basal-luminal interface. Embryonic deletion of Pdpn targeted to basal cells diminished basal and luminal SC activity and affected the expression of several Wnt/β-catenin signaling components in basal cells. Moreover, Pdpn loss attenuated mammary tumor formation in a mouse model of β-catenin-induced breast cancer, limiting tumor-initiating cell expansion and promoting molecular features associated with mesenchymal-to-epithelial cell transition. In line with the loss-of-function data, we demonstrated that mechanistically Pdpn enhances Wnt/β-catenin signaling in mammary basal cells. Overall, this study uncovers a role for Pdpn in mammary SC function and, importantly, identifies Pdpn as a new regulator of Wnt/β-catenin signaling, a key pathway in mammary development and tumorigenesis.
Kinetic Asymmetry during Running at Preferred and Nonpreferred Speeds
Authors: FURLONG LAURA-ANNE M. , EGGINTON NATALIE L. 
Published: January 2018

ABSTRACT

Purpose
The aim of this study was to investigate the effect of altering preferred running speed by ±20% on kinetic asymmetry.

Methods
Three-dimensional motion analysis and force data were acquired from 15 healthy males (age, 27 ± 4.6 yr; height, 1.81 ± 0.09 m; mass, 80.4 ± 12.4 kg) during their preferred running speed and at ±20% of this speed. Three-tesla magnetic resonance images were used to measure Achilles tendon cross-sectional area and moment arm, for use in calculation of tendon stress. Kinetic and tendon stress asymmetry were subsequently calculated in each condition using the symmetry index.

Results
Across all joints and conditions, the average asymmetry of peak moments was between ±6%, but higher individual values were observed. There was no effect of speed on the magnitude of asymmetry. Ground contact times, vertical ground reaction forces, and support and ankle moments (maximum absolute asymmetry, 9%) were more symmetrical than hip and knee moments (up to 18%). Individual joint contribution to support moment and positive work were similar in both limbs, and ankle and hip compensatory interactions were observed with alterations in running speed. Achilles tendon stress increased with increased running speed, with higher stress in the preferred limb; asymmetry in tendon stress was not related to asymmetry in vertical ground reaction forces.

Conclusion
Results show small effects of altering running speed on kinetic asymmetry, but responses are individual specific with interactions occurring between joints to maintain overall movement symmetry. Further research is needed to understand the mechanical and neuromuscular mechanisms underpinning these compensations.
The orchestrated crowd: Choreography, chorus, conceit in Tino Sehgal’s These Associations
Authors: E Richards Mary 
Published: January 2018

Abstract
In 2012 artist Tino Sehgal created These Associations, the last in the Unilever series of commissions for the Tate Modern’s Turbine Hall, London. Within this space Sehgal transformed and challenged the role of the public and ‘participants’ or interpreters in the creation of a relational art piece which represents ‘[…] a direct response to the shift from a goods to a service-based economy’ (Bishop 2004: 54). In common with earlier works by Sehgal, and with the ‘social turn’ of relational aesthetics, These associations (2012), is centrally concerned with alternative modes of production. And as has been extensively noted elsewhere (Umathum 2009, Pape, Solomon and Thain, 2014, Green 2017) Sehgal is uninterested in adding to the ever-increasing mass of objects in the world. Instead he asks; how do we think of production in our times? How (and what) can we produce without producing objects?
Immersive performance and somatic practices: Joan Davis and the Maya Lila project
Authors: Meehan Emma 
Published: January 2018

Abstract
In this article, I focus on the work of Irish choreographer Joan Davis in order to draw out a debate on the value offered by somatic movement approaches to the field of immersive performance. Such works immerse audiences and performers in sensory, site-based and participatory performance. There has been a recent surge in the popularity of immersive theatre experiences and scholarship on this topic, with the writings for example of Alston, Harvie, Machon and White examining issues such as the agency of audience members and the relationship between individual freedom and group responsibility. What do somatic performances, which often physically immerse participants in outdoor environments, found spaces or designed installations, have to offer this field of theory and practice? Drawing on ideas in environmental theatre and performance ecology, including the work of Reeve, Kershaw and Schechner, I explore the relationship between people, sites, objects and wildlife in somatic performances as part of a whole ecology in shifting negotiation. I propose that although active, individual, experiential participation is part of these performances, body– mind reflective engagement in relationship to context is a vital contribution that somatics can offer to immersive practice more generally. This will be discussed in relation to Joan Davis’ Maya Lila project (2002–15), as she invites participants to become aware of their behaviours within installation environments, as a means to explore being within and separate from a community, and challenging expectations, perceptions and actions.
‘Berthing Bone’: A poem
Authors: Gray Victoria 
Published: January 2018

Abstract
Berthing Bone (Gray, 2014) is a poem composed during the devising, filming and editing of an artists’ moving image film. Conceived as a series of choreographed sculptures for the hands, the film performs a close-reading of the hand. Throughout the process of filming and post-production, a poetic text was written with the intent of performing an equally close, specifically kinaesthetic reading of the hand. During the exhibition of the film, the poem was performed live, alongside the screening. In the following artists’ pages, the poem is transferred from the mouth to the page, and is accompanied by four stills from the Berthing Bone film. The reader is invited to read the poem aloud.
Listening for Disappearing – a choreoauratic practice
Authors: Wood Becca 
Published: January 2018

Abstract
This practice-led research is situated at the intersections between spatial design, somatics, sound art, sitebased performance and social choreography. A creative practice that thinks through doing, it interrogates the potential of a choreoauratic site-based performance practice to bring attention to the politics of public places, somatically, architecturally, and socially.
A new term choreoauratics is cultivated out of this practice-led research. It argues for the convergence of prosthetic listening and choreography as a critical spatial practice. Participatory choreographies intervene in public spaces, working poetically towards a recovery of the imperceptible, disappearing and the lost. Performing in the margins, the practice orchestrates an emergent form of public activism.
Social choreographies for the ears affect and politicise the way we inhabit and incorporate spaces. A new kind of subjectivity emerges through headphonic sound technologies and choreography. This activates the subject and the city in collisions and convergence, coming together in the striated, dispersed virtual space of listening prosthetically. Engaging in the unspectacular, the practice treads lightly, tuning into the intensities of the poetic, sound, the voice, place and the moving body.
Locating culture, making soundscapes and activating critical social relations: A case study from Limerick SoundScapes
Authors: Dillane Aileen , Power Martin J. , Devereux Eoin 
Published: January 2018

Abstract
Limerick SoundScapes is a sound-mapping project that seeks to critically engage citizens of the multicultural, socially and economically divided post-industrial City of Limerick in the Republic of Ireland. Facilitated by an interdisciplinary team at the local university, citizens from all walks of life are encouraged to traverse the city, using hand-held recorders to capture a vast array of sounds and create soundscapes. Initially, we locate the project within the context of a city currently experiencing a state-sponsored programme of urban regeneration. The project is also understood in terms of top-down and bottom-up cultural initiatives, particularly in relation to Limerick’s designation as National City of Culture 2014. In addition to looking at how Limerick SoundScapes was conceived and realized through a pilot programme in 2013, we focus specifically on two members of two local participating organizations as an example of how the project operates. Through the activities and experiences of these two volunteer recordists, we illustrate how the project is as much (if not more) focused on engagement and building social relations as it is on producing a finished product that seeks to sonically and culturally represent the city. Such projects have the capacity to promote real diversity and a critical and participatory citizenship through shared, creative goals and a dialogic of doing. However, we also show that culture is often understood in a particular way in Limerick, which we argue is to the detriment of investing in bottom-up projects that can potentially build ‘institutional capacity’ and boost ‘civic creativity’.
Cultural organizations, collaborative contexts and public: How they become small communities
Authors: Borges Vera 
Published: January 2018

Abstract
While some of our early studies on cultural policy focus on the role played by central government in the support of Portuguese artistic and cultural organizations, more attention should be paid to the way in which the local work of organizations can be developed by examining the collaborative art contexts that had predated government funding. We introduce the idea that collaborative contexts are feeding and boosting organizations’ work and, consequently, enhancing the effect of the government aid that targets local communities. Using a multiple case-study methodology, we argue that culture goes beyond state funding and we illustrate this by examining the cultural projects developed by artistic organizations in five Portuguese inter-municipal communities with different collaborative profiles and geographies. We find that informal contexts, networks and partnerships foster the local collaboration of cultural organizations and enhance their reputation. We also draw attention to other complementary dynamics introduced by the collaborative art process such as the increase in cultural organizations’ activities; the growth of local professionals, thus fostering the local arts profiles and creation itself; the greater cosmopolitanism of cultural organizations that operate in cities, villages or districts and move in international arenas; and finally, the intensification of cultural experiences and conviviality with the participating public.
Calvino’s snails: Fiction, reality and memory in Bamboleho
Authors: Michelotti Graciela 
Published: January 2018

Abstract
Parallels between humans and animals suggested by the film’s poetic language provide a look at Spain’s lack of opportunities for generations of children living in the margins. Meanwhile, references to Calvino’s novel The Baron in the Trees (1959) bring up Bamboleho’s interest in exploring issues concerning the representation of reality and memory.
Reagan’s Farewell Address: Redefining the American Dream
Authors: Rowland Robert C. , Jones John M. 
Published: January 2018

Abstract
This essay argues that President Ronald Reagan’s Farewell Address used a perfected and condensed form of ultimate definition consisting of an ideological argument, an underlying mythic narrative, and a value system. These three components served to redefine the American Dream and to reinforce the limited role of government, placing the responsibility for curing America’s ills on the individual rather than the federal government.
Extended Mellin integral representations for the absolute value of the gamma function
Authors: Privault Nicolas 
Published: January 2018

Abstract
We derive Mellin integral representations in terms of Macdonald functions for the squared absolute value

s
↦

|

Γ
⁢

(

a
+

i
⁢
s

)

|

2

{s\mapsto|\Gamma(a+is)|^{2}}

of the gamma function and its Fourier transform when

a
<
0

{a<0}

is non-integer, generalizing known results in the case

a
>
0

{a>0}

.
This representation is based on a renormalization argument using modified Bessel functions of the second kind, and it applies to the representation of the solutions of a Fokker–Planck equation.