bluuebunny/crossref_metadata_2025_split huggingface dataset:
ВПЛИВ ПЕРФУЗІЙНОГО ТИСКУ ТА ВАЗОПРЕСОРІВ НА РИЗИК ПІСЛЯОПЕРАЦІЙНИХ УСКЛАДНЕНЬ ПРИ ПАНКРЕАТОДУОДЕНЕКТОМІЇ
Authors: УСЕНКО О. Ю. , СИДЮК О. М. , СИМОНОВ О. М. , АНТОНЕНКО М. В. 
Published: September 2024

Мета роботи: дослідити вплив перфузійного тиску та застосування вазопресорів на частоту виникнення післяопераційних панкреатичних фістул (ПОПФ) та інших ускладнень у пацієнтів після панкреатодуоденектомії. Оскільки ПОПФ є одним із найсерйозніших ускладнень, що вимагає тривалого лікування та може призвести до збільшення летальності, знання про фактори ризику їх виникнення є критично важливими для оптимізації післяопераційного менеджменту.
Матеріали і методи. Аналіз охопив 234 пацієнтів, що перенесли панкреатодуоденектомію протягом 2022–2023 років. Дослідження базувалося на ретроспективному огляді даних, зібраних у Національному науковому центрі хірургії та трансплантології імені О. О. Шалімова. Вивчали перфузійний тиск, застосування вазопресорів, тривалість операції, текстуру кукси підшлункової залози, а також використання профілактичної антибіотикотерапії.
Результати. У нашому дослідженні, яке включало з 234 пацієнти (150 чоловіків та 84 жінки, середній вік 68 років) було виявлено, що панкреатичні фістули (ПОПФ) виникли у 44 пацієнтів (18,8 %), з яких 27 випадків були класифіковані як ступінь B (61,36 %) та 17 випадків – як ступінь C (38,64 %) згідно з класифікацією ISGPS. Середня тривалість операції становила близько 356 хвилин. Аналіз показав, що зниження перфузійного тиску на 1 мм рт. ст. значно (p<0,05) підвищує ризик ПОПФ на 158 %. Дозування вазопресора норепінефрину не продемонструвало статистично значимого впливу на ризик ПОПФ (p>0,05), що свідчить про можливість безпечного використання вазопресорів для корекції гіпотензії, не збільшуючи ризик ускладнень.
Статистичний аналіз виявив значущу різницю показників середнього перфузійного тиску між групами з ПОПФ та без нього, де група без ПОПФ мала вищий середній перфузійний тиск (71,15 мм рт. ст.), порівняно з групою з ПОПФ (66,55 мм рт. ст.) з p-критерієм приблизно 6,91×10−7. Тривалість операції також значимо відрізнялася і була довшою у випадках з ПОПФ (391,05 хвилин) порівняно з випадками без ПОПФ (348,01 хвилин), з p-критерієм 0,0057. Однак, середній обсяг крововтрати, хоча й був вищим у групі з ПОПФ, не досяг статистичної значимості (p=0,0554), що свідчить про відсутність значущої різниці за цим показником.
За результатами ROC-аналізу було визначено, що перфузійний тиск нижче 69,35 мм рт. ст. асоціюється зі значним підвищенням ризику ПОПФ, що може слугувати пороговим значенням для ідентифікації пацієнтів високого ризику та впровадження відповідних профілактичних заходів. Площа під ROC-кривою (AUC) становить приблизно 0.76, що підтверджує добру діагностичну здатність моделі відрізняти випадки з ПОПФ від випадків без ПОПФ.
Ці результати підкреслюють важливість моніторингу перфузійного тиску як критичного фактора для запобігання розвитку ПОПФ після панкреатодуоденектомії, а також важливість додаткових досліджень для оптимізації використання вазопресорів у цій категорії пацієнтів.
МАЛОКОНТАКТНИЙ БАГАТОПЛОЩИННИЙ ОСТЕОСИНТЕЗ ПЕРЕЛОМІВ ШИЙКИ СТЕГНОВОЇ КІСТКИ
Authors: БІЛІНСЬКИЙ П. І. , БУТ В. П. , МАРЧУК Т. Є. 
Published: September 2024

Мета роботи: поліпшити результати лікування хворих із ПШСК з використанням малоконтактного багатоплощинного остеосинтезу і кісткової пластики.
Матеріали і методи. Ми проаналізували 32 випадки незадовільного застосування традиційних фіксаторів при несвіжих переломах шийки стегнової кістки (СК). Аналізували залежність результатів лікування від якості репозиції відламків, травматичності оперативного втручання, початку і величини дозованого і повного навантаження, їх впливу на зростання фрагментів. Для остеосинтезу ПШСК нами розроблений пристрій для остеосинтезу переломів проксимального відділу стегна (ПОППВС – пат. України № 22283) [5]. Фіксація фрагментів пристроєм здійснювалась фігурним Т-подібним стержнем, який фіксується в короткій пластині з наскрізним пазом. Цей стержень мінімально травмує фрагменти, його ширина складає 9 мм. Він має вертикальну полицю, яка забезпечує деротаційний ефект при мінімальному об’ємі. Розроблений нами ПОППВС із позитивним результатом використаний у 128 пацієнтів з медіальними ПШСК.
Результати. При доброму зіставленні фрагментів методом скелетного витягання можна фіксувати їх 2–3 спицями Ілізарова завдовжки 20 сантиметрів, проведеними через підвертлюгову ділянку.
Паралельно дузі Адамса робиться канал у шийці СК, куди вводиться Т-подібний стержень. Він стабілізується болтом у пазі короткої накладної пластини з півкільцем. Кращі результати при субкапітальних і діагональних ПШСК забезпечує застосування спонгіозного гвинта, проведеного паралельно до фігурного стержня ПОППВС. У складних випадках ми використовуємо автотрансплантат довжиною до 5–6 см із великогомілкової кістки. Цього достатньо для перекриття лінії перелому. У 5 пацієнтів автотрансплантат узято із підвертлюгової ділянки СК. Така методика не травмує гомілку, зменшує тривалість оперативного втручання.
Повне навантаження ми рекомендуємо через 5–6 місяців з моменту операції. Дозоване навантаження можливе уже через 1,5–2 місяці. Після кісткової автопластики – через 10–12 місяців.
Висновки. Застосування ПОППВС значно спрощує проведення остеосинтезу при ПШСК, здійснює мінімальну травматизацію фрагментів, стабільну їх фіксацію, поліпшує життя пацієнтів після операції. Практика підтверджує певні переваги органозберігальних втручань.
Canjerê Ibaô: o inventário participativo de patrimônio cultural, a comunidade e as africanidades
Authors: Gama Alessandra Regina 
Published: September 2024

As considerações deste artigo resultam de uma investigação que se propôs acompanhar o processo de uma experiência local, defendida na dissertação de mestrado “Canjerê: uma performance cartográfica em patrimônio cultural, educação e africanidades”, realizada pelo Programa de Pós-Graduação Graduação em Educação da Universidade Federal de São Carlos. O movimento desta pesquisa considera o inventário participativo como um processo colaborativo e propositivo no campo das expressividades culturais negras, tecendo reflexões sobre as hostilidades sociais que afetam as singularidades de cultura e memória centradas nas africanidades e como a perspectiva da Ecologia de Saberes pode contribuir para a produção de conhecimentos, numa perspectiva justa e equilibrada de saberes no campo patrimonial.
Insights into RNA N6-methyladenosine and programmed cell death in atherosclerosis
Authors: Long Haijiao , Yu Yulu , Ouyang Jie , lu Hongwei , Zhao Guojun 
Published: September 2024

AbstractN6-methyladenosine (m6A) modification stands out among various RNA modifications as the predominant form within eukaryotic cells, influencing numerous cellular processes implicated in disease development. m6A modification has gained increasing attention in the development of atherosclerosis and has become a research hotspot in recent years. Programmed cell death (PCD), encompassing apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis, plays a pivotal role in atherosclerosis pathogenesis. In this review, we delve into the intricate interplay between m6A modification and diverse PCD pathways, shedding light on their complex association during the onset and progression of atherosclerosis. Clarifying the relationship between m6A and PCD in atherosclerosis is of great significance to provide novel strategies for cardiovascular disease treatment.
Molecular mechanism and potential role of mitophagy in acute pancreatitis
Authors: Zhu Lili , Xu Yunfei , Lei Jian 
Published: September 2024

AbstractAcute pancreatitis (AP) is a multifaceted inflammatory disorder stemming from the aberrant activation of trypsin within the pancreas. Despite the contribution of various factors to the pathogenesis of AP, such as trypsin activation, dysregulated increases in cytosolic Ca2+ levels, inflammatory cascade activation, and mitochondrial dysfunction, the precise molecular mechanisms underlying the disease are still not fully understood. Mitophagy, a cellular process that preserves mitochondrial homeostasis under stress, has emerged as a pivotal player in the context of AP. Research suggests that augmenting mitophagy can mitigate pancreatic injury by clearing away malfunctioning mitochondria. Elucidating the role of mitophagy in AP may pave the way for novel therapeutic strategies. This review article aims to synthesize the current research findings on mitophagy in AP and underscore its significance in the clinical management of the disorder.
Segregation GWAS to linearize a non-additive locus with incomplete penetrance: an example of horn status in sheep
Authors: Duijvesteijn Naomi , van der Werf Julius H. J. , Kinghorn Brian P. 
Published: September 2024

Abstract
Background
The objective of this study was to introduce a genome-wide association study (GWAS) in conjunction with segregation analysis on monogenic categorical traits. Genotype probabilities calculated from phenotypes, mode of inheritance and pedigree information, are expressed as the expected allele count (EAC) (range 0 to 2), and are inherited additively, by definition, unlike the original phenotypes, which are non-additive and could be of incomplete penetrance. The EAC are regressed on the single nucleotide polymorphism (SNP) genotypes, similar to an additive GWAS. In this study, horn phenotypes in Merino sheep are used to illustrate the advantages of using the segregation GWAS, a trait believed to be monogenic, affected by dominance, sex-dependent expression and likely affected by incomplete penetrance. We also used simulation to investigate whether incomplete penetrance can cause prediction errors in Merino sheep for horn status.

Results
Estimated penetrance values differed between the sexes, where males showed almost complete penetrance, especially for horned and polled phenotypes, while females had low penetrance values for the horned status. This suggests that females homozygous for the ‘horned allele’ have a horned phenotype in only 22% of the cases while 78% will be knobbed or have scurs. The GWAS using EAC on 4001 animals and 510,174 SNP genotypes from the Illumina Ovine high-density (600k) chip gave a stronger association compared to using actual phenotypes. The correlation between the EAC and the allele count of the SNP with the highest –log10(p-value) was 0.73 in males and 0.67 in females. Simulations using penetrance values found by the segregation analyses resulted in higher correlations between the EAC and the causative mutation (0.95 for males and 0.89 for females, respectively), suggesting that the most predictive SNP is not in full LD with the causative mutation.

Conclusions
Our results show clear differences in penetrance values between males and female Merino sheep for horn status. Segregation analysis for a trait with mutually exclusive phenotypes, non-additive inheritance, and/or incomplete penetrance can lead to considerably more power in a GWAS because the linearized genotype probabilities are additive and can accommodate incomplete penetrance. This method can be extended to any monogenic controlled categorical trait of which the phenotypes are mutually exclusive.
Unilateral amelanotic conjunctival malignant melanoma: a case report
Authors: Ayala Marcelo , Erripi Kalliopi , Johansson Iva 
Published: September 2024

Abstract
Introduction
Cutaneous malignant melanomas rarely occur in the eye, usually in the eyelids or the conjunctiva. Conjunctival malignant melanomas are even rarer. Most melanomas are dark in color as they are pigmented. However, amelanotic conjunctival malignant melanomas, a scarce variant of the cancer, can be challenging to diagnose accurately.

Case presentation
We present two cases of white Caucasian Swedish-born women who were diagnosed with unilateral amelanotic malignant melanoma in the conjunctiva of the eye. In the first case, the patient was an 81-year-old woman who was suffering from redness and foreign body sensation in the left eye. The initial diagnosis was blepharitis. Three biopsies were taken, which showed malignant melanoma in the eyelid and the conjunctiva. Unfortunately, the eye and the rest of the orbit could not be saved, and the patient had to undergo an orbital exenteration. In the second case, the patient was a 50-year-old woman, and the tumor was localized in the temporal conjunctiva of the left eye. The initial diagnosis was pinguecula, but at the time of surgery, the physician suspected conjunctival intraepithelial neoplasia. The tumor was not completely removed, so adjuvant brachytherapy and local chemotherapy were used. The eye was preserved. No neck and/or lung metastasis was detected in either case at the time of diagnosis.

Conclusions
Conjunctival amelanotic malignant melanomas should be suspected when tumors are present in the eye and/or the eyelids. By suspecting amelanotic malignant melanoma, the delay in treatment can be shortened. Treating them as soon as possible is essential to minimize the risk of metastasis.
Serum IgA antibody level against porcine epidemic diarrhea virus is a potential pre-evaluation indicator of immunization effects in sows during parturition under field conditions
Authors: Hu Zhiqiang , Li Yang , Zhang Bingzhou , Zhao Ying , Guan Ran , Zhou Yapeng , Du Jiafa , Zhang Zhimin , Li Xiaowen 
Published: September 2024

Abstract
Background
Porcine Epidemic Diarrhea (PED) is a highly contagious disease caused by Porcine Epidemic Diarrhea Virus (PEDV), resulting in a mortality rate of suckling piglets as high as 100%. Vaccination is the primary strategy for controlling PEDV infection, however, there is currently a lack of reliable methods for assessing the efficacy of vaccination. This study aimed to analyze serum and colostrum samples from 75 parturient sows with a specific vaccination strategy to measure levels of IgG, IgA, and neutralizing antibodies (nAbs) against PEDV, and to investigate the correlation between serum and colostrum antibody levels, as well as to identify potential biomarkers that can be used to evaluate immunization effects under field conditions.

Results
The findings of correlation analysis between antibody levels of IgA, IgG, and nAbs in serum or colostrum samples revealed that IgG demonstrated the most robust correlation with nAbs exhibiting a correlation coefficient of 0.64 in serum samples. Conversely, IgA exhibited the highest correlation with nAbs, with a correlation coefficient of 0.47 in colostrum samples. Additionally, the correlation analysis of antibody levels between serum and colostrum samples indicated that serum IgA displayed the strongest correlation with colostrum IgA, with a coefficient of 0.63, indicating that serum IgA may serve as a viable alternative indicator for evaluating IgA levels in colostrum samples. To further evaluate the suitability of serum IgA as a substitute marker for colostrum IgA, levels of IgA antibodies in serum samples from sows were examined both pre- and post-parturition. The findings indicated that serum IgA levels were initially low prior to the initial immunization, experienced a notable rise 21 days after immunization, and maintained a significant elevation compared to pre-immunization levels from 21 days pre-parturition to 14 days postpartum, spanning a total of 35 days.

Conclusions
Serum anti-PEDV IgA antibody levels may serve as a valuable predictor for immunization effects, allowing for the assessment of colostrum IgA antibody levels up to 21 days in advance. This insight could enable veterinarians to timely adjust or optimize immunization strategies prior to parturition, thereby ensuring adequate passive immunity is conferred to piglets through colostral transfer postpartum.
Development of green manufacturing implementation framework based on life-cycle assessment
Authors: Ijaz Tehrim , Qazalbash Agha Haider Raza , Razzaq Ahmed Abdul , Rafique Muhammad Zeeshan , Khan Mohammad Aamir , Jamshaid Syeda Hadika 
Published: September 2024

AbstractClimate change stabilization at 1.5 to 2 °C requires a shift in paradigm of industries to transition to low carbon industries. The way forward to decarbonize industries is green manufacturing, as the environmental facet of manufacturing has often been compromised for the sake of economic gains. In order to implicate green manufacturing, it is incumbent upon manufacturing facilities to introduce such measures which ensure that carbon footprint and environmentally detrimental emissions are minimized. In this context, Life-cycle Assessment (LCA) is an excellent tool to record, analyze and critically review the environmental impact of a process. In order to investigate the environmental hotspots, the authors have performed LCA of an auto-parts manufacturing industry in Pakistan by using a unique gate-to-gate approach. ReCiPe Midpoint impact assessment method was utilized to investigate the effects of manufacturing and transportation related emissions of the monthly produce on climate change, fossil depletion, ionizing radiation and human toxicity. Furthermore, the authors discuss three scenarios, which include current state, optimized future state and an energy mix involving hydropower and photovoltaic generation. The results helped in developing a comprehensive framework for green manufacturing which suggests that the prerequisite of a green manufacturing process is an optimized process flow, which significantly reduces the environmental emissions up to 24%. Moreover, the use of photovoltaic cells results in 54% reduction, thus indicating that conventional hydropower systems in developing countries should be mixed with solar power to reduce the environmental burden. A detailed green manufacturing framework based on LCA is proposed by the authors to enhance the functionality and to improvise the carbon burden of the manufacturing sector of Pakistan.
Effective extracorporeal treatment of metformin-associated lactic acidosis using continuous venovenous hemodiafiltration
Authors: Brouwer Mèdea , Offermans Mandy , van Nuil Lisanne , Poukens Astrid , van Oijen Brigit , Dormans Tom 
Published: September 2024

Background: The prevalence of type 2 diabetes mellitus has surged globally. Metformin is recommended as the first-line oral treatment. However, metformin-associated lactic acidosis (MALA) is recognized as a rare but potentially dangerous complication. The pathogenesis of MALA is multifactorial, primarily resulting from the interference of metformin with mitochondrial function and hepatic gluconeogenesis, leading to lactate accumulation. Risk of MALA escalates with impaired kidney function, poorly controlled diabetes, fasting, and liver dysfunction. Case Description: A 57-year-old woman with diabetes and hypertension presented with prolonged gastrointestinal symptoms. During this episode she continued using metformin. She had severe metabolic acidosis and acute kidney injury. Continuous venovenous hemodiafiltration was initiated, resulting in significant clinical improvement and normalized arterial blood gas parameters within 16 hours. Discussion: The pharmacokinetic properties of metformin facilitate efficient elimination via hemodialysis and/or hemofiltration. Continuous venovenous hemodiafiltration emerges as effective for MALA treatment. In the case described the calculated metformin clearance during continuous venovenous hemodiafiltration was notably higher than reported values, possibly due to residual renal clearance. Clinical improvement occurred despite elevated metformin levels, suggesting a lack of correlation between metformin levels and patient outcomes. Comorbidities rather than metformin levels guide treatment decisions in MALA. Conclusion: This case underscores the efficacy of continuous venovenous hemodiafiltration in the treatment of MALA, suggesting its potential as a standard therapeutic approach. However, further research is needed
Deep neck infections mortal complications: Intrathoracic complications and necrotising fasciitis
Authors: Bal Kemal Koray , Aslan Can , Gür Harun , Bal Seda Turk , Ustun Recep Okan , Unal Murat 
Published: September 2024

BACKGROUND
We planned this study considering that complications of deep neck infections can be seriously life threatening.
AIM
To raise awareness that introthoracic complications and necrotizing fasciitis are causes of serious mortality and morbidity.
METHODS
This study was carried out with the participation of 188 patients who were treated at Mersin University Department of Otorhinolaryngology and Head and Neck Surgery at January 1, 2024. When the patient files were retrospectively examined, 16 of 188 patients (8.5%) were included in the study because they were observed to have necrotizing fasciitis and/or intrathoracic complications.
RESULTS
There were a total of 16 patients in this study, 9 males (56.25%) and 7 females (43.75%). All patients were adults (> 18 years) and the mean age was 50.37 years ± 15.37 years. Female patients had a mean age of 40.42 years ±13.38 years, whereas for male patients was 58.11 years ± 12.44 years.
CONCLUSION
Patients with necrotizing fasciitis and/or intrathoracic complications require more complicated and serious surgeries, intensive care unit monitoring, and mechanical ventilator support. Higher rates of morbidity and mortality should be expected in these patients who are hospitalized for longer periods of time.
Low-latency 100 Gb/s PAM-4 PON with a 42.5 dB power budget over the 20 km anti-resonant hollow-core fiber
Authors: Chen Hui , Zhang Lei , Zhang Xu , Wang Qibing , Li Chao , Jin Siyue , Liu Xumeng , Liu Zichen , Ji Honglin , Xu Zhaopeng , Luo Jie , Wang Lei , Zhang Junwen , He Zhixue , Chi Nan , Yu Shaohua 
Published: September 2024

The surging growth in data traffic has necessitated the development of higher-speed, lower-latency intensity modulation and direct detection (IM/DD) passive optical networks (PONs) with higher power budgets. To address the inherent limitations of traditional silica-based solid-core fibers, anti-resonant hollow-core fibers have garnered significant attention from both academia and industry. In this Letter, we present an experimental demonstration of 100 Gb/s PAM-4 IM/DD PON transmission over a 20 km anti-resonant hollow-core fiber in the C band, utilizing low-complexity digital signal processing (DSP). The result achieves a record high power budget of 42.5 dB, facilitated by a 3-tap weighted lookup table (LUT) at the optical line terminal (OLT) side and a semiconductor optical amplifier used as a preamplifier at the optical network unit (ONU) side. This represents the highest power budget reported for IM/DD PON to date, to the best of our knowledge, and offers a promising alternative for the future evolution of PON systems.