bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of platelet-rich plasma and triamcinolone acetonide on interleukin-1ß-stimulated human rotator cuff-derived cells
Authors: Muto T. , Kokubu T. , Mifune Y. , Inui A. , Sakata R. , Harada Y. , Takase F. , Kurosaka M. 
Published: December 2016

Objectives Triamcinolone acetonide (TA) is widely used for the treatment of rotator cuff injury because of its anti-inflammatory properties. However, TA can also produce deleterious effects such as tendon degeneration or rupture. These harmful effects could be prevented by the addition of platelet-rich plasma (PRP), however, the anti-inflammatory and anti-degenerative effects of the combined use of TA and PRP have not yet been made clear. The objective of this study was to determine how the combination of TA and PRP might influence the inflammation and degeneration of the rotator cuff by examining rotator cuff-derived cells induced by interleukin (IL)-1ß. Methods Rotator cuff-derived cells were seeded under inflammatory stimulation conditions (with serum-free medium with 1 ng/ml IL-1ß for three hours), and then cultured in different media: serum-free (control group), serum-free + TA (0.1mg/ml) (TA group), serum-free + 10% PRP (PRP group), and serum-free + TA (0.1mg/ml) + 10% PRP (TA+PRP group). Cell morphology, cell viability, and expression of inflammatory and degenerative mediators were assessed. Results Exposure to TA significantly decreased cell viability and changed the cell morphology; these effects were prevented by the simultaneous administration of PRP. Compared with the control group, expression levels of inflammatory genes and reactive oxygen species production were reduced in the TA, PRP, and TA+PRP groups. PRP significantly decreased the expression levels of degenerative marker genes. Conclusions The combination of TA plus PRP exerts anti-inflammatory and anti-degenerative effects on rotator cuff-derived cells stimulated by IL-1ß. This combination has the potential to relieve the symptoms of rotator cuff injury. Cite this article: T. Muto, T. Kokubu, Y. Mifune, A. Inui, R. Sakata, Y. Harada, F. Takase, M. Kurosaka. Effects of platelet-rich plasma and triamcinolone acetonide on interleukin-1ß-stimulated human rotator cuff-derived cells. Bone Joint Res 2016;5:602–609. DOI: 10.1302/2046-3758.512.2000582.
Decrease of Serum IGF-I following Transsphenoidal Pituitary Surgery for Acromegaly
Authors: Yu Min , Bruns David E , Jane John A , Nass Ralf M , Oldfield Edward H , Vance Mary Lee , Thorner Michael O 
Published: December 2016

Abstract

BACKGROUND
In the immediate postoperative period following resection of growth hormone (GH)-secreting pituitary tumors, serum concentrations of GH have limited ability to predict remission of acromegaly. Since many actions of GH actions are mediated by insulin-like growth factor-1 (IGF-I), we aimed to determine the rates of fall of IGF-I during 72 h after surgical resection of pituitary tumors.

METHODS
We studied patients who were undergoing pituitary surgery for acromegaly. IGF-I was measured by LC-MS and GH by immunoassay. Remission was defined by the combination of serum GH &lt;0.4 ng/mL during oral glucose tolerance testing performed 8 weeks after the surgical procedure and normal IGF-I at ≥8 weeks.

RESULTS
During the first 72 h after surgery, the mean (SD) rate of decline of IGF-I was 185 (61) ng/mL per 24 h in those who achieved remission (n = 23), with a mean (SD) apparent half-life of 55 (19) h. IGF-I had decreased to &lt;65% of the preoperative IGF-I on postoperative day 2 in 20 of 23 remission patients (87%) vs none of 5 patients who did not achieve remission. GH was &lt;2.7 ng/mL on day 2 in 21 of 23 remission patients (91%), but in none of the nonremission patients. The combination of IGF-I and GH on day 2 separated the remission and nonremission groups of patients.

CONCLUSIONS
Rapid decline of serum IGF-I during the immediate postoperative period warrants further study as an analytically independent adjunct to GH measurement for early prediction of biochemical remission of acromegaly.
Pinturas del taller de Rubens legadas en Logroño en 1623
Authors: Barrón García Aurelio A. , Aramburu-Zabala Higuera Miguel Ángel 
Published: December 2016

El canónigo José de Velasco y su hermano Juan de Velasco, secretario de Ambrogio Spinola durante más de veinte años, legaron en Logroño unos cuarenta cuadros flamencos de los que únicamente se conoce el paradero de los que confiaron a la iglesia de Santa María de Palacio. Se proponen como parte del legado tres obras desconocidas del taller de Rubens que se conservan en Santa María la Redonda de Logroño y en la iglesia parroquial de Javier (Navarra): un Cristo crucificado de tamaño natural y dos cuadros de San Ignacio y San Francisco Javier.
On an asymmetric extension of multivariate
Archimedean copulas based on quadratic
form
Authors: Di Bernardino Elena , Rullière Didier 
Published: December 2016

Abstract
An important topic in Quantitative Risk Management concerns the modeling of dependence among
risk sources and in this regard Archimedean copulas appear to be very useful. However, they exhibit symmetry,
which is not always consistent with patterns observed in real world data. We investigate extensions
of the Archimedean copula family that make it possible to deal with asymmetry. Our extension is based on
the observation that when applied to the copula the inverse function of the generator of an Archimedean
copula can be expressed as a linear form of generator inverses. We propose to add a distortion term to this
linear part, which leads to asymmetric copulas. Parameters of this new class of copulas are grouped within
a matrix, thus facilitating some usual applications as level curve determination or estimation. Some choices
such as sub-model stability help associating each parameter to one bivariate projection of the copula. We
also give some admissibility conditions for the considered copulas. We propose different examples as some
natural multivariate extensions of Farlie-Gumbel-Morgenstern or Gumbel-Barnett.
Robustness regions for measures of risk
aggregation
Authors: Pesenti Silvana M. , Millossovich Pietro , Tsanakas Andreas 
Published: December 2016

Abstract
One of risk measures’ key purposes is to consistently rank and distinguish between different risk
profiles. From a practical perspective, a risk measure should also be robust, that is, insensitive to small perturbations
in input assumptions. It is known in the literature [14, 39], that strong assumptions on the risk
measure’s ability to distinguish between risks may lead to a lack of robustness. We address the trade-off between
robustness and consistent risk ranking by specifying the regions in the space of distribution functions,
where law-invariant convex risk measures are indeed robust. Examples include the set of random variables
with bounded second moment and those that are less volatile (in convex order) than random variables in a
given uniformly integrable set. Typically, a risk measure is evaluated on the output of an aggregation function
defined on a set of random input vectors. Extending the definition of robustness to this setting, we find
that law-invariant convex risk measures are robust for any aggregation function that satisfies a linear growth
condition in the tail, provided that the set of possible marginals is uniformly integrable. Thus, we obtain that
all law-invariant convex risk measures possess the aggregation-robustness property introduced by [26] and
further studied by [40]. This is in contrast to the widely-used, non-convex, risk measure Value-at-Risk, whose
robustness in a risk aggregation context requires restricting the possible dependence structures of the input
vectors.
VaR bounds for joint portfolios with
dependence constraints
Authors: Puccetti Giovanni , Rüschendorf Ludger , Manko Dennis 
Published: December 2016

Abstract
Based on a novel extension of classical Hoeffding-Fréchet bounds, we provide an upper VaR bound
for joint risk portfolios with fixed marginal distributions and positive dependence information. The positive
dependence information can be assumed to hold in the tails, in some central part, or on a general subset of
the domain of the distribution function of a risk portfolio. The newly provided VaR bound can be interpreted
as a comonotonic VaR computed at a distorted confidence level and its quality is illustrated in a series of
examples of practical interest.
Crowdfunding: Motives, Definitions, Typology and Ethical Challenges
Authors: Hossain Mokter , Oparaocha Gospel Onyema 
Published: December 2016

AbstractCrowdfunding is an emerging phenomenon that has attracted significant interest from scholars and practitioners alike, mainly due to its appeal as an alternative source of funding. As crowdfunding has grown exponentially, so have the associated challenges and opportunities. In this conceptual paper, we define crowdfunding; discuss its characteristics, related terminologies, key elements and ethical issues. We also propose a typology for crowdfunding and indicate various issues associated with it. The final section includes the implications of this study and suggestions for future research. This paper aims to inspire a scholarly debate and further develop the theoretical foundation of the crowdfunding literature. This may also prompt practitioners to take note of the emerging concerns as the crowdfunding phenomenon is transforming from a marginal to a mainstream discipline.
Design of Microstrip Lowpass Filter with Sharp Roll-off using Elliptical and Radial Resonators
Authors: Karimi Gholamreza , Lotfi Saeedeh , Siahkamari Hesam 
Published: December 2016

AbstractA new microstrip lowpass filter with sharp roll-off and high suppression level in stop-band is presented. To achieve the lowpass filter with high performance, coupled T-shaped, elliptical and radial resonators are adopted. New formulas for calculating
10 to 40 GHz Superheterodyne Receiver Frontend in 0.13 µm SiGe BiCMOS Technology
Authors: Abdeen Hebat-Allah Yehia , Yuan Shuai , Schumacher Hermann , Ziegler Volker , Meusling Askold , Feldle Peter 
Published: December 2016

AbstractA fully integrated 10–40 GHz superheterodyne receiver frontend using a 40–46 GHz IF is presented. The frontend consists of a differential low noise amplifier, a fully differential mixer, a single-ended frequency quadrupler and a transformer-based balun followed by an amplifier to convert the quadrupler’s single-ended output to a differential signal to drive the LO port of the mixer. The circuit is designed and fabricated in a 250 GHz
Piecewise synergetic systems and applications in biochemical systems theory
Authors: Ponosov Arcady , Machina Anna , Tafintseva Valeria 
Published: December 2016

Abstract
We study piecewise synergetic systems originating from Biochemical Systems Theory. In the first part of the paper, the emphasis is put on practical calculations with such systems. We consider four examples: calculation of trajectories and steady states, solution of an optimization problem and a method of estimation of parameters (kinetic orders), all examples being biologically motivated. In the second part of the paper, we study convergence of solutions, in particularly, steady states, of a sequence of piecewise synergetic systems approximating an arbitrary compartment model. This convergence analysis is then applied to the optimization problem and the method of estimating sensitivities (kinetic orders) in a generic compartment model. In this paper we put forward arguments for the importance of the theoretical and numerical analysis of piecewise synergetic systems.
The Economic Value of Book Loans – The Case of the Municipal Library of Prague
Authors: Stejskal Jan , Hájek Petr , Rehak Tomas 
Published: December 2016

AbstractIn recent years, the value of public library services has tended to be evaluated using the contingent valuation method. This is able to reveal readers’ hidden preferences. However, it appears that the total value of a public library as expressed by one number leads to a methodological bias related to the difficulty of assessing the value of one standard book loan. Moreover, this approach does not reflect the needs of public libraries’ management. Therefore, this study focuses on a detailed investigation of the most important public library service, book loans. For this purpose, we have employed statistical models to identify the significant determinants of willingness to pay (WTP) for book loans and WTP for purchasing books, respectively. The results suggest that loan services have the greatest perceived value for students, people who are economically active. Management who are interested in increasing the success of their institution across society must also know the perceived value of individual books so that they can adjust their library's acquisition policy. It was found that novels had the highest perceived value, followed by educational literature in the fields of economics and education as well as information science. This entirely new analytical method of measuring WTP for public services raises many new implications that could change the strategies of individual libraries – as well as the public policy strategies of donors and library ownership.
Machine learning for metagenomics: methods and tools
Authors: Soueidan Hayssam , Nikolski Macha 
Published: December 2016

AbstractOwing to the complexity and variability of metagenomic studies, modern machine learning approaches have seen increased usage to answer a variety of question encompassing the full range of metagenomic NGS data analysis.We review here the contribution of machine learning techniques for the field of metagenomics, by presenting known successful approaches in a unified framework. This review focuses on five important metagenomic problems:OTU-clustering, binning, taxonomic proffiing and assignment, comparative metagenomics and gene prediction. For each of these problems, we identify the most prominent methods, summarize the machine learning approaches used and put them into perspective of similar methods.We conclude our review looking further ahead at the challenge posed by the analysis of interactions within microbial communities and different environments, in a field one could call “integrative metagenomics”.
Corrosion and mechanical properties of AM50 magnesium alloy after modified by different amounts of rare earth element Gadolinium
Authors: Yang Miao , Zhang Zhiyi , Liu Yaohui , Han Xianlong 
Published: December 2016

Abstract
To improve the corrosion and mechanical properties of the AM50 magnesium alloy, different amounts of the rare earth element gadolinium were used. The microstructure, corrosion and mechanical properties were evaluated by X-ray diffraction, scanning electron microscopy, energy dispersive spectroscopy, and electrochemical and mechanical stretch methods. The results indicate that, with Gd addition, the amount of the Al2Gd3 phase increased while the β-Mg17Al12 phase amount decreased. Due to the Gd addition, the grain of the AM50 magnesium alloy was significantly refined, which improved its tensile strength. Further, the decrease in the amount of the β phase improved the corrosion resistance of the alloy. The fracture mechanism of the Gd-modified AM50 magnesium alloy was a quasi-cleavage fracture. Finally, the optimum corrosion residual strength of the AM50 magnesium alloy occurred with 1 wt.%of added Gd.
Mind the gap: From Inter- to Transculturality in Dutch Literature?
Authors: Lücke Nicole M.H. 
Published: December 2016

AbstractThis paper focuses on current issues relating to cultural encounters in contemporary Dutch literature. The starting point is transculturality - a concept suggesting a new way of looking at culture that is frequently applied as an alternative to concepts such as multi- and interculturality. This article deals with theoretical issues as well as with the question whether transculturality is appropriate when characterizing how cultural contacts are represented in literature. The results of this case study based on a literary analysis of Kader Abdolah’s short story “Een onbekende trekvogel” provide a strong argument for modifying the concept of transculturality and sharpening awareness for increasing interrelations of individuals, societies, institutions and nations.
Transnational literary history? Dutch-speaking writers in Karel van het Reve’s ‘ventistic’ Geschiedenis van de Russische Literatuur [History of Russian Literature]
Authors: Dobbeleer Michel De 
Published: December 2016

AbstractIn his Geschiedenis van de Russische literatuur [History of Russian Literature, 1985] the famous Dutch Slavist and essayist Karel van het Reve, links Russian writers, such as Gavriil Derzhavin and Aleksei Pisemskii to Dutch and Flemish ones, such as Vondel and Willem Elsschot. Further on, in the chapter on Lev Tolstoi, Multatuli’s Max Havelaar is cited, although it is clear from the start that none of these Dutch-speaking authors could have had any influence on the Russian writers to whom Van het Reve devotes his colourful chapters. In this article I explore the ‘transnational’ potential of Van het Reve’s self-willed literary-historiographical approach. It turns out that Van het Reve mentions most of these Dutch-speaking authors rather to indicate - directly or indirectly - that he (dis)likes them, than to contribute to the achievements of comparative literature. Both in his choice of authors and his way of practicing literary historiography Van het Reve manifests himself as a proponent of the vent (cf. the well-known vorm of vent or manner or man discussion). Nevertheless, some of his observations could be considered as transnational constellations (in the world-literature sense of the term).
“It Is Really a Big Achievement for a Small Community Like the One of Curaçao.” Jan Greshoff (1888–1971) and De Stoep (1940–1951): An Exploration
Authors: Bant Willem 
Published: December 2016

Abstract
During the Second World War, both in the Dutch East Indies and in Curaçao, journals were published in which Dutch authors could publish their works unhampered by German censorship. In addition, literary works in Dutch were published in the Dutch East Indies, South Africa and New York. A man involved in all these initiatives was Jan Greshoff, an author who had played an important role in Dutch literature during the time between the two world wars. In this article, the role of Greshoff in relation to the literary journal De Stoep, which originated in Curaçao after the German occupation of Holland in 1940, will be explored. Although he never went to Curaçao and never met the journal’s founder, Luc. Tournier, in person, Greshoff played an important role in the history of De Stoep during the years of the war, and thus indirectly in the development of Dutch literature in Curaçao.
Ancient Book Culture and the Literacy of James: On the Production and Consumption of a Pseudepigraphal Letter
Authors: Fewster Gregory P. 
Published: December 2016

Abstract:This article inquires into the implicit pseudepigraphal construction of James the brother of Jesus as highly literate in the canonical letter attributed to him. Traditional, form-based approaches to the letter genre are set aside in favour of appreciating the production and composition of (pseudepigraphal) letters within the context of Ancient Mediterranean book culture, particularly the association between scribal literate ability and social status. The pairing of James’ literary ability with the transmission of Jesus tradition is an image propagated in other early Christian literature, including the
Cyprian, Paul, and Care for the Poor and Captive: Offering Sacrifices and Ransoming Temples
Authors: Murphy Edwina 
Published: December 2016

Abstract:The ways in which Cyprian appropriates Scripture to address the challenges facing his flock give us an insight into how theology, text, and context are interwoven in his biblical interpretation. As a contribution to studies in the reception of Paul and early North African exegesis, I examine all the quotations of and allusions to the canonical Paul in Cyprian’s exhortations to care for the poor and captive. This reveals him to be a creative interpreter of Scripture, employing reading strategies of model, image, direct application, and qualification, as well as tailoring them to serve his aims in particular works. Also evident is that, here at least, Cyprian’s promotion of almsgiving is not linked to patronage; rather, he uses Paul to promote a counter-cultural attitude—pleasing God rather than cultivating clients.
Adam and the Logos: Aphrahat’s Christology in Demonstration 17 and the “Imponderables of Hellenization”
Authors: Fiano Emanuel 
Published: December 2016

Abstract:Aphrahat’s presumed unawareness of contemporary theological developments has often puzzled scholars, who as a result have deemed his theological views “archaic” and bereft of any Hellenic influence. This image, which has begun to be questioned by a series of studies, can be further corrected by an examination of the central section, dealing with the begetting of Adam, of a
Stimulation of Dorsolateral Prefrontal Cortex Enhances Adaptive Cognitive Control: A High-Definition Transcranial Direct Current Stimulation Study
Authors: Gbadeyan Oyetunde , McMahon Katie , Steinhauser Marco , Meinzer Marcus 
Published: December 2016

Conflict adaptation is a hallmark effect of adaptive cognitive control and refers to the adjustment of control to the level of previously experienced conflict. Conflict monitoring theory assumes that the dorsolateral prefrontal cortex (DLPFC) is causally involved in this adjustment. However, to date, evidence in humans is predominantly correlational, and heterogeneous with respect to the lateralization of control in the DLPFC. We used high-definition transcranial direct current stimulation (HD-tDCS), which allows for more focal current delivery than conventional tDCS, to clarify the causal involvement of the DLPFC in conflict adaptation. Specifically, we investigated the regional specificity and lateralization of potential beneficial stimulation effects on conflict adaptation during a visual flanker task. One hundred twenty healthy participants were assigned to four HD-tDCS conditions: left or right DLPFC or left or right primary motor cortex (M1). Each group underwent both active and sham HD-tDCS in crossover, double-blind designs. We obtained a sizeable conflict adaptation effect (measured as the modulation of the flanker effect as a function of previous response conflict) in all groups and conditions. However, this effect was larger under active HD-tDCS than under sham stimulation in both DLPFC groups. In contrast, active stimulation had no effect on conflict adaptation in the M1 groups. In sum, the present results indicate that the DLPFC plays a causal role in adaptive cognitive control, but that the involvement of DLPFC in control is not restricted to the left or right hemisphere. Moreover, our study confirms the potential of HD-tDCS to modulate cognition in a regionally specific manner.SIGNIFICANCE STATEMENTConflict adaptation is a hallmark effect of adaptive cognitive control. While animal studies have suggested causal involvement of the DLPFC in this phenomenon, such evidence is currently lacking in humans. The present study used high-definition transcranial direct current stimulation (HD-tDCS) to demonstrate that the DLPFC is causally involved in conflict adaptation in humans. Our study confirms a central claim of conflict monitoring theory, which up to now has predominantly relied on correlational studies. Our results further indicate an equal involvement of the left and right DLPFC in adaptive control, whereas stimulation of a control region—the primary motor cortex—had no effect on adaptive control. The study thus confirms the potential of HD-tDCS to modulate cognition in a regionally specific manner.