bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Fc–Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor
Authors: Hsiao Po‐Yuan , Kalin Jay H. , Sun Im‐Hong , Amin Mohammed N. , Lo Ying‐Chun , Chiang Meng‐Jung , Giddens John , Sysa‐Shah Polina , Gabrielson Kathleen , Wang Lai‐Xi , Powell Jonathan D. , Cole Philip A. 
Published: July 2016

AbstractThe adenosine A2A receptor (A2AR) is expressed in immune cells, as well as brain and heart tissue, and has been intensively studied as a therapeutic target for multiple disease indications. Inhibitors of the A2AR have the potential for stimulating immune response, which could be valuable for cancer immune surveillance and mounting a response against pathogens. One well‐established potent and selective small molecule A2AR antagonist, ZM‐241385 (ZM), has a short pharmacokinetic half‐life and the potential for systemic toxicity due to A2AR effects in the brain and the heart. In this study, we designed an analogue of ZM and tethered it to the Fc domain of the immunoglobulin IgG3 by using expressed protein ligation. The resulting protein–small molecule conjugate, Fc–ZM, retained high affinity for two Fc receptors: FcγRI and the neonatal Fc receptor, FcRn. In addition, Fc–ZM was a potent A2AR antagonist, as measured by a cell‐based cAMP assay. Cell‐based assays also revealed that Fc–ZM could stimulate interferon γ production in splenocytes in a fashion that was dependent on the presence of A2AR. We found that Fc–ZM, compared with the small molecule ZM, was a superior A2AR antagonist in mice, consistent with the possibility that Fc attachment can improve pharmacokinetic and/or pharmacodynamic properties of the small molecule.
Selective Deposition of Silver Oxide on Single‐Domain Ferroelectric Nanoplates and Their Efficient Visible‐Light Photoactivity
Authors: Chen Fang , Ren Zhaohui , Gong Siyu , Li Xiang , Shen Ge , Han Gaorong 
Published: July 2016

AbstractIn this work, single‐crystal and single‐domain PbTiO3 nanoplates are employed as substrates to prepare Ag2O/PbTiO3 composite materials through a photodeposition method. It is revealed that silver oxide nanocrystals with an average size of 63 nm are selectively deposited on the positive polar surface of the ferroelectric substrate. The possible mechanism leading to the formation of silver oxide is that silver ions are first reduced to silver and then oxidized by oxygen generation. The composite shows an efficient photodegradation performance towards rhodamine B (RhB) and methyl orange (MO) under visible‐light irradiation. Such highly efficient photoactivity can be attributed to the ferroelectric polarization effect of the substrate, which promotes the separation of photogenerated electrons and holes at the interface.
Visible‐Light‐Induced Trifluoromethylation of Isonitrile‐Substituted Methylenecyclopropanes: Facile Access to 6‐(Trifluoromethyl)‐7,8‐Dihydrobenzo[k]phenanthridine Derivatives
Authors: Yuan Yu‐Chao , Liu Hou‐Lu , Hu Xu‐Bo , Wei Yin , Shi Min 
Published: July 2016

AbstractA new visible‐light‐induced trifluoromethylation of isonitrile‐substituted methylenecyclopropanes is developed. A range of substituted 6‐(trifluoromethyl)‐7,8‐dihydrobenzo[k]phenanthridine derivatives are readily furnished by this newly developed tandem reaction with moderate to good yields. This reaction allows the direct formation of two six‐membered rings and three new C−C bonds, including the C−CF3 bond, under visible light irradiation.
TBAI‐Catalyzed/Water‐Assisted Double C−S Bond Formations: An Efficient Approach to Sulfides through Metal‐Free Three‐Component Reactions
Authors: Chu Xue‐Qiang , Xu Xiao‐Ping , Ji Shun‐Jun 
Published: July 2016

AbstractAn aqueous catalytic method for double C−S bond formations that involves alcohol derivatives, organic halides, and sodium thiosulfate has been developed. A diverse range of functionalized sulfides, including pharmaceutical and biological derivatives, can be obtained in an efficient and eco‐friendly manner under air. The mechanistic studies revealed that this tetrabutylammonium‐iodide‐catalyzed/water‐assisted reaction generated a mercaptan species as the key intermediate.
A phase 1 dose‐escalation study of filanesib plus bortezomib and dexamethasone in patients with recurrent/refractory multiple myeloma
Authors: Chari Ajai , Htut Myo , Zonder Jeffrey A. , Fay Joseph W. , Jakubowiak Andrzej J. , Levy Joan B. , Lau Kenneth , Burt Steven M. , Tunquist Brian J. , Hilder Brandi W. , Rush Selena A. , Walker Duncan H. , Ptaszynski Mieke , Kaufman Jonathan L. 
Published: July 2016

BACKGROUNDFilanesib is a kinesin spindle protein inhibitor that has demonstrated encouraging activity in patients with recurrent/refractory multiple myeloma. Preclinical synergy with bortezomib was the rationale for the current phase 1 study.METHODSThe current study was a multicenter study with an initial dose‐escalation phase to determine the maximum tolerated dose of 2 schedules of filanesib plus bortezomib with and without dexamethasone, followed by a dose‐expansion phase.RESULTSWith the addition of prophylactic filgastrim, the maximum planned dose was attained: 1.3 mg/m2/day of bortezomib plus 40 mg of dexamethasone on days 1, 8, and 15 of a 28‐day cycle, with filanesib given intravenously either at a dose of 1.5 mg/m2/day (schedule 1: days 1, 2, 15, and 16) or 3 mg/m2/day (schedule 2: days 1 and 15). The most common adverse events (assessed for severity using version 4.0 of the National Cancer Institute Common Terminology Criteria for Adverse Events) were transient, noncumulative neutropenia and thrombocytopenia with grade 3/4 events reported in 44% (16% in cycle 1 with filgastrim) and 29% of patients, respectively. A low (≤11%) overall rate of nonhematological grade 3/4 toxicity was observed. With a median of 3 prior lines of therapy and 56% of patients with disease that was refractory to proteasome inhibitors, the overall response rate was 20% (55 patients), and was 29% in 14 patients with proteasome inhibitors‐refractory disease receiving filanesib at a dose of ≥1.25 mg/m2 (duration of response, 5.2 to ≥21.2 months).CONCLUSIONSThe current phase 1 study established a dosing schedule for the combination of these agents that demonstrated a favorable safety profile with a low incidence of nonhematologic toxicity and manageable hematologic toxicity. The combination of filanesib, bortezomib, and dexamethasone appears to have durable activity in patients with recurrent/refractory multiple myeloma. Cancer 2016;122:3327–3335. © 2016 American Cancer Society.
A novel relay nucleus between the inferior colliculus and the optic tectum in the chicken (Gallus gallus)
Authors: Niederleitner Bertram , Gutierrez‐Ibanez Cristian , Krabichler Quirin , Weigel Stefan , Luksch Harald 
Published: July 2016

ABSTRACTProcessing multimodal sensory information is vital for behaving animals in many contexts. The barn owl, an auditory specialist, is a classic model for studying multisensory integration. In the barn owl, spatial auditory information is conveyed to the optic tectum (TeO) by a direct projection from the external nucleus of the inferior colliculus (ICX). In contrast, evidence of an integration of visual and auditory information in auditory generalist avian species is completely lacking. In particular, it is not known whether in auditory generalist species the ICX projects to the TeO at all. Here we use various retrograde and anterograde tracing techniques both in vivo and in vitro, intracellular fillings of neurons in vitro, and whole‐cell patch recordings to characterize the connectivity between ICX and TeO in the chicken. We found that there is a direct projection from ICX to the TeO in the chicken, although this is small and only to the deeper layers (layers 13–15) of the TeO. However, we found a relay area interposed among the IC, the TeO, and the isthmic complex that receives strong synaptic input from the ICX and projects broadly upon the intermediate and deep layers of the TeO. This area is an external portion of the formatio reticularis lateralis (FRLx). In addition to the projection to the TeO, cells in FRLx send, via collaterals, descending projections through tectopontine‐tectoreticular pathways. This newly described connection from the inferior colliculus to the TeO provides a solid basis for visual‐auditory integration in an auditory generalist bird. J. Comp. Neurol. 525:513–534, 2017. © 2016 Wiley Periodicals, Inc.
Tuning Colloidal Stability of Layered Double Hydroxides: From Monovalent Ions to Polyelectrolytes
Authors: Pavlovic Marko , Rouster Paul , Oncsik Tamas , Szilagyi Istvan 
Published: July 2016

AbstractThe growing number of applications of layered double hydroxide (LDH) colloids demands for detailed understanding of particle aggregation processes in such samples. Tuning the colloidal stability in aqueous suspensions is essential to design stable systems or to induce controlled aggregation of these elongated particles. In this review, recent progress in this field is summarized; in particular, the charging and aggregation of LDHs of various compositions and sizes in the presence of different aggregating agents are discussed. The review focuses on the effect of monovalent salts, multivalent ions, and polyelectrolytes on the suspension stability of LDHs. The provided information will help to better understand the origin of interparticle forces responsible for the colloidal stability and to design highly stable or aggregating LDH colloids according to the desired goals in certain applications. Moreover, potential future research directions to obtain a broader picture of LDH aggregation are also suggested.
Quantifying the human influence on fire ignition across the westernUSA
Authors: Fusco Emily J. , Abatzoglou John T. , Balch Jennifer K. , Finn John T. , Bradley Bethany A. 
Published: July 2016

AbstractHumans have a profound effect on fire regimes by increasing the frequency of ignitions. Although ignition is an integral component of understanding and predicting fire, to date fire models have not been able to isolate the ignition location, leading to inconsistent use of anthropogenic ignition proxies. Here, we identified fire ignitions from the Moderate Resolution Imaging Spectrometer (MODIS) Burned Area Product (2000–2012) to create the first remotely sensed, consistently derived, and regionally comprehensive fire ignition data set for the western United States. We quantified the spatial relationships between several anthropogenic land‐use/disturbance features and ignition for ecoregions within the study area and used hierarchical partitioning to test how the anthropogenic predictors of fire ignition vary among ecoregions. The degree to which anthropogenic features predicted ignition varied considerably by ecoregion, with the strongest relationships found in the Marine West Coast Forest and North American Desert ecoregions. Similarly, the contribution of individual anthropogenic predictors varied greatly among ecoregions. Railroad corridors and agricultural presence tended to be the most important predictors of anthropogenic ignition, while population density and roads were generally poor predictors. Although human population has often been used as a proxy for ignitions at global scales, it is less important at regional scales when more specific land uses (e.g., agriculture) can be identified. The variability of ignition predictors among ecoregions suggests that human activities have heterogeneous impacts in altering fire regimes within different vegetation types and geographies.
Conducting Polyaniline Nanowire Arrays Modified Electrode for High Performance Supercapacitor and Enhanced Catalysis of Nitrite Reduction
Authors: Hui Ni , Wang Jiasheng , Liang Aiqin , Jiang Meilin 
Published: July 2016

AbstractVertically aligned conducting polymer nanowire arrays had great potential applications in supercapacitor electrode material and exhibited enhanced electrocatalytic behavior towards the reduction of nitrite. In this paper, a facial template‐free approach to synthesize large arrays of vertically aligned polyaniline (PANI) nanowires on electrochemically pretreated glassy carbon electrodes was reported by using a galvanostatic current method. The as‐prepared large arrays of PANI nanowires had very narrow diameters and were oriented perpendicular to the substrate, which was a benefit to the ion diffusion when being used as the supercapacitor electrode. The highest specific capacitance of PANI nanowire arrays was measured and kept high at a large charge‐discharge current density. Furthermore, it also can detect nitrite with ultrahigh sensitivity of 62.99 µA mM−1 cm−2 and a remarkable fast response time of less 1 s. The results indicated that the vertically aligned PANI nanowires could dramatically enhance the electrochemical performance.
Diffusion, Adsorption and Electrode Kinetics of Electro‐oxidatons on a Stationary Solid Electrode
Authors: Bozal‐Palabiyik Burcin , Kurbanoglu Sevinc , Uslu Bengi , Ozkan Sibel A. , Zuman Petr 
Published: July 2016

AbstractThe i‐E oxidation curves, obtained using a boron doped diamond electrode, for studies of oxidations of two piperazine derivatives ARIP (I) and PIRI (II), resulted in a sharp increase of current in the range of the oxidation potentials. After reaching a value, depending on concentration of I or II, the current remains practically constant up to +1.6 V. Such limiting currents i1 are a linear function of concentrations and depend on the v1/2. Hence it is diffusion controlled, shifts of the oxidation potentials indicate, that the monoprotonated forms are oxidized. At more negative potentials a limiting current i2 occurs, due to the oxidation of the diprotonated form. Current i2 increases with decreasing pH in a shape of a part of a dissociation curve. Diffusion control reflects the large size of molecules I and II. The two‐electron oxidations yield a C=N bond in the piperazine ring. It seems to be the first reported diffusion controlled oxidation curves obtained on a stationary solid electrode.
Controls on the occurrence and prevalence of floodplain channels in meandering rivers
Authors: David Scott R. , Edmonds Douglas A. , Letsinger Sally L. 
Published: July 2016

AbstractThe process of channelization on river floodplains plays an essential role in regulating river sinuosity and creating river avulsions. Most channelization occurs within the channel belt (e.g. chute channels), but growing evidence suggests some channels originate outside of the channel‐belt in the floodplain. To understand the occurrence and prevalence of these floodplain channels we mapped 3064 km2 of floodplain in Indiana, USA using 1.5 m resolution digital elevation models (DEMs) derived from airborne light detection and ranging (LiDAR) data. We find the following range of channelization types on floodplains in Indiana: 6.8% of floodplain area has no evidence of channelization, 55.9% of floodplains show evidence (e.g. oxbow lakes) of chute‐channel activity in the channel belt, and 37.3% of floodplains contain floodplain channels that form long, coherent down‐valley pathways with bifurcations and confluences, and they are active only during overbank discharge. Whereas the first two types of floodplains are relatively well studied, only a few studies have recognized the existence of floodplain channels. To understand why floodplain channels occur, we compared the presence of channelization types with measured floodplain width, floodplain slope, river width, river meander rate, sinuosity, flooding frequency, soil composition, and land cover. Results show floodplain channels occur when the fluvial systems are characterized by large floodplain‐to‐river widths, relatively higher meandering rates, and are dominantly used for agriculture. More detailed reach‐scale mapping reveals that up to 75% of channel reaches within floodplain channels are likely paleo‐meander cutoffs. The meander cutoffs are connected by secondary channels to form floodplain channels. We suggest that secondary channels within floodplains form by differential erosion across the floodplain, linking together pre‐existing topographic lows, such as meander cutoffs. Copyright © 2016 John Wiley & Sons, Ltd.
The morphological response of foredunes at a breached barrier system to winter 2013/2014 storms on the southwest coast of Ireland
Authors: Kandrot Sarah , Farrell Eugene , Devoy Robert 
Published: July 2016

AbstractThe level of storminess in Ireland during the winter of 2013/2014 was exceptional, the effects of which cost the Irish state in excess of €260 million in infrastructure repair and insurance claims. In Ireland, a lack of coastal process data from monitoring programmes means that the response of protective barrier coasts to such events remains largely un‐investigated. This study addresses this issue through an examination of the geomorphic impacts of recent storms, including those that occurred during the winter 2013/2014, on a breached barrier on the southwest coast of Ireland. Data from a two‐year terrestrial laser scanning (TLS) monitoring campaign shows that the winter 2013/2014 events caused a major (>50 m) dune recession at Rossbehy, County Kerry. Results from a simple linear regression analysis indicate storm duration plays an important role in the removal of foredunes at the study site. Given the fact that the frequency of intense storms in the vicinity of Ireland is forecast to increase within the next century, a scientific understanding of barrier response to such events is critical to inform sound management practices. Copyright © 2016 John Wiley & Sons, Ltd.
Cigarette use, comorbidities, and prognosis in a prospective head and neck squamous cell carcinoma population
Authors: Peterson Lisa A. , Bellile Emily L. , Wolf Gregory T. , Virani Shama , Shuman Andrew G. , Taylor Jeremy M. G. , Rozek Laura S. ,   The University of Michigan Head and Neck Specialized Program of Research Excellence Program
Published: July 2016

ABSTRACTBackgroundTo better understand the associations between a history of tobacco use and survival outcomes, cigarette use was prospectively surveyed in 687 previously untreated patients with cancer of the oral cavity (n = 271), oropharynx (n = 257), larynx (n = 135), or hypopharynx (n = 24).MethodsKaplan–Meier and Cox models explored the associations of tobacco use intensity (packs/day), duration (years of use), and timing before diagnosis with overall survival (OS), disease‐specific survival (DSS), and recurrence‐free survival (RFS).ResultsCigarette use duration, timing, and intensity were significant predictors for all outcomes in univariate analysis. Never smoking and pack‐years were not significantly associated with outcomes after adjustment for prognostic factors, such as stage, comorbidities, and human papillomavirus (HPV) status, which were strongly associated with clinical outcomes.ConclusionThe findings confirm the association between smoking history and survival and the importance of clinical variables in evaluating smoking as a prognostic factor. Timing, intensity, and duration of cigarette use should be considered with other prognostic factors when considering risk stratification for treatment planning. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1810–1820, 2016
Homogenisation of temperature and precipitation time series with ACMANT3: method description and efficiency tests
Authors: Domonkos P. , Coll J. 
Published: July 2016

ABSTRACTThe development of Adapted Caussinus–Mestre Algorithm for homogenising Networks of Temperature series (ACMANT), one of the most successful homogenisation methods tested by the European project COST ES0601 (HOME) has been continued. The third generation of the software package ‘ACMANT3’ contains six programmes for homogenising temperature values or precipitation totals. These incorporate two models of the annual cycle of temperature biases and homogenisation either on a monthly or daily time scale. All ACMANT3 programmes are fully automatic and the method is therefore suitable for homogenising large datasets. This paper describes the theoretical background of ACMANT and the recent developments, which extend the capabilities, and hence, the application of the method. The most important novelties in ACMANT3 are: the ensemble pre‐homogenisation with the exclusion of one potential reference composite in each ensemble member; the use of ordinary kriging for weighting reference composites; the assessment of seasonal cycle of temperature biases in case of irregular‐shaped seasonal cycles. ACMANT3 also allows for homogenisation on the daily scale including for break timing assessment, gap filling and ANOVA application on the daily time scale. Examples of efficiency tests of monthly temperature homogenisation using artificially developed but realistic test datasets are presented. ACMANT3 can be characterized by improved efficiency in comparison with earlier ACMANT versions, high missing data tolerance and improved user friendliness. Discussion concerning when the use of an automatic homogenisation method is recommended is included, and some caveats in relation to how and when ACMANT3 should be applied are provided.
The Role of Posttraumatic Growth in a Randomized Controlled Trial of Cognitive–Behavioral Conjoint Therapy for PTSD
Authors: Wagner Anne C. , Torbit Lindsey , Jenzer Tiffany , Landy Meredith S. H. , Pukay‐Martin Nicole D. , Macdonald Alexandra , Fredman Steffany J. , Monson Candice M. 
Published: July 2016

AbstractPosttraumatic growth (PTG) is defined as a positive psychological change that can emerge following a traumatic life event. Although documented in noninterventional studies of traumatized individuals, there are scant data on the potential for therapy to induce or improve PTG. Thus, the primary goal of this study was to examine changes in PTG in a controlled trial of cognitive–behavioral conjoint therapy for posttraumatic stress disorder versus waitlist (CBCT for PTSD; Monson & Fredman, 2012). We also examined whether pretreatment relationship satisfaction and PTSD symptomatology moderated change in PTG. There were 40 couples (75% with a female partner with PTSD) who were randomized to either immediate CBCT for PTSD or a 3‐month waitlist (WL). Compared to WL, individuals who received treatment immediately demonstrated a significant increase in PTG. There was a moderate effect size between‐group difference (Hedge's g = 0.45). There was a nonsignificant relationship with a moderate effect size (Hedge's g = 0.65) for the positive effect of pretreatment relationship satisfaction on the trajectory of PTG, but no effect of pretreatment PTSD symptoms. Results suggested that CBCT for PTSD facilitated PTG, even with a limited focus on PTG in this conjoint intervention. Future research should target PTG as a treatment goal and further examine the role of close others in facilitating development of PTG.