bluuebunny/crossref_metadata_2025_split huggingface dataset:
2,3,7,8-Tetrachlorodibenzo-p-Dioxin Suppresses Mesenchymal Cell Proliferation and Migration Through miR-214-3p in Cleft Palate
Authors: dong Xiaobo , Chen Qiang , Du Haojuan , Qiu Lin 
Published: September 2024

Objective The aetiology of CL/P is complicated, with both genetic and environmental factors. This study aimed to investigate the association between TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) exposure and changes in the expression of miR-214-3p in the context of cleft palate. Design In this study, we established a fetal mouse cleft palate model using TCDD and differentially expressed miRNAs were analysed by microarray analysis and verified by qRT-PCR. Finally, we demonstrated the effects of TCDD and microRNAs on the proliferation and migration of mesenchymal cells by using CCK8, EDU, Transwell, and wound-healing assays. Results Our findings revealed significant upregulation of miRNAs such as miR-214-3p, miR-296-5p, and miR-33-5p in the TCDD intervention group, while miRNAs like miR-92a-3p, miR-126a-3p, and miR-411-5p were significantly downregulated. Notably, qRT-PCR testing confirmed a significant difference in miR-214-3P expression. Further investigations involved the overexpression of miR-214-3p, reducing cell proliferation and migration in primary mouse embryonic palatal mesenchymal (MEPM) cells. Conclusions These results are consistent with the finding that TCDD suppresses palatal mesenchymal cell proliferation and migration through miR-214-3p. In conclusion, miR-214-3p probably plays a role in TCDD-induced cleft palates in mice.
Economic Impact of Ambulatory Blood Pressure Monitoring Compared With Clinical Blood Pressure Monitoring: A Simulation Model
Authors: Hayek Michelle A , Catacora Alejandro , Lawley Mark A , Kum Hye-Chung , Ohsfeldt Robert L 
Published: September 2024

Background: Ambulatory blood pressure monitoring (ABPM) is considered the gold standard for proper diagnosis of hypertension. Yet, access to ABPM in the U.S. is limited, and the extent of coverage by commercial health plans remains uncertain, potentially limiting access to ABPM among commercially insured patients. Objective: This study aims to assess the net cost impact of using ABPM in comparison to clinical blood pressure monitoring (CBPM) in the U.S. over a 5-year time period. Design methods: Using a Markov Model, we estimate the 5-year cumulative cost impact of using ABPM to confirm a prior diagnosis of primary hypertension using CBPM to avoid treatment for white-coat hypertension (WCH) in a hypothetical cohort of 1000 patients from a U.S. healthcare system perspective. The probability and cost inputs for the model were derived from available literature. Base-case model parameters were varied to account for different scenarios. Results: Base-case results indicate using ABPM instead of CBPM over 5 years saves a total of $348,028, reflecting an average per-person-per-year (PPPY) cost saving of $70. In sensitivity analyses, almost all cases reveal ABPM as a cost-saving approach compared to CBPM, with cost savings reaching up to $228 PPPY in the highest hypertension treatment cost model. Regression results reveal that ABPM was cost-saving compared to CBPM if ABPM annual payment rates are $100 or less and annual hypertension treatment costs are ⩾$300. Conclusion: The potential cost-savings of using ABPM instead of CBPM found in our simulation model underscores the need for confirmatory research using real-world data to support increased use of ABPM as the standard diagnostic approach for hypertension.
Medico-Legal Complaints Against Dermatologists: Data From the Canadian Medical Protective Association, 2013 to 2022
Authors: Ma Bryan , Park Ye-Jean , Han Jing , Gandhi Maharshi , Ramien Michele , Klassen David , Payant Laura , Rose Elaine , Garber Gary , Probst Mireille , Hardin Jori 
Published: September 2024

Background: Medico-legal complaints against physicians are a significant source of anxiety and could be associated with defensive medical practices that may correlate with poor patient outcomes. Little is known about patient concerns brought to regulatory bodies and courts against dermatologists in Canada. Objective: To characterize factors contributing to medico-legal complaints brought against dermatologists in Canada. Methods: The Canadian Medical Protective Association (CMPA) repository was queried for all closed cases involving dermatologists over the past decade. Aggregate, anonymized data was reviewed and case outcomes, patient harm, and contributing factors were extracted. Results: Nearly one-fifth of all dermatologists who are CMPA members have been named in at least one medico-legal case between 2013 to 2022. A total of 396 civil-legal actions or College complaint cases involving dermatologists were closed at the CMPA during this timeframe. The most common patient allegations were deficient assessment (34%), diagnostic error (28%), and unprofessional manner (22%). Nearly half of patients experienced a harmful event, the majority of which were asymptomatic or mild. The most frequently identified contributing factors related to providers were poor clinical decision making (n = 73), lack of situational awareness (n = 67), and conduct and boundary issues (n = 59). Team factors included a breakdown of communication with patients (n = 124). Conclusions: Improved communication with patients for informed consent, treatment plans, clinical follow-up, and documentation of thorough clinical patient assessments can improve patient satisfaction and health outcomes, and mitigate dermatologists’ medico-legal risk.
Molecular features of NSCLC patients with liver metastasis
Authors: Zhao Jun , Zhong Jia , Chen Yujie , Chen Zipei , Yin Huan , He Yuange , Chen Rongrong , Guo Renhua 
Published: September 2024

Background: Metastasis is the primary cause of lung cancer-related death. Primary cancer cells invade through the lymphatic or blood vessels to distant sites. Recently, it was proposed that lymphatic metastasis was more a hallmark of tumor aggressiveness or metastatic potential than a gateway to metastases. Therefore, the underlying molecular mechanism of metastasis is not entirely clear. Objectives: This study aimed to explore the genetic mechanisms underlying liver metastases from lung cancer and to evaluate the efficacy of different therapies in these patients. Design: We retrospectively analyzed the mutation spectrum of different biopsy samples including primary lung tumors, liver, lymph node metastasis, and circulating tumor DNA (ctDNA) from 1090 non-small-cell lung cancer (NSCLC) patients with liver metastasis between the years 2017 and 2022. Methods: Demographic and disease characteristics were summarized using descriptive parameters. Time to treatment discontinuation was used to analyze the clinical outcome. Results: More liquid biopsies were performed than tissue biopsies, especially in the treated advanced NSCLC patients. Liver metastasis before treatment was associated with poor response to immune checkpoint inhibitors and targeted therapy. Liver and lymph node metastasis had higher levels of single nucleotide variants and copy number variants than primary lung tumors. In paired lung and liver, lymph nodes, and simultaneous ctDNA, we found actionable mutations were always shared, while metastasis samples had multiple private mutations. Serial ctDNA analysis identifies potential resistant mutations and describes the evolution of tumor cells. Conclusion: Liver and lymph node metastasis in NSCLC showed shared actionable mutations. Of note, the discrepancy of private mutations in liver and lymph node metastases indicated that liver metastases are mainly seeded by the primary tumor rather than the earlier colonized lymph node metastases.
Illness representation in patients with multiple sclerosis: A preliminary narrative medicine study
Authors: Paolucci T , Reho M , Ciacchella C , Veneziani G , Santoro I , Fiorentino G , Galli F , Lai C 
Published: September 2024

Background The development of personalized interventions aimed at coping with multiple sclerosis is enriched by the understanding of patients’ representations of the illness. Objective The aim of this study was to investigate the association between patients’ illness representations versus contextual factors (i.e. presence/absence and type of caregiver, engagement, frequency and type of rehabilitation), fatigue, pain, and neurological impairment. Methods Interviews of 28 patients were analysed through an automated text analysis procedure. After a systematic labelling procedure four illness representations were identified: daily life, search for meaning of the disease, relationship to people and the diagnosis, coping and physical growth. Results Findings showed that the representation of the relational aspects of the illness was associated with the caregiver's presence, while the representation related to coping and growth tended to be associated with participation in rehabilitation programs. Moreover, the representation related to daily life was associated with lower levels of fatigue compared to the representation related to coping and growth, and with higher levels of neurological impairment compared to the representations related to coping and growth and the relational aspects of the illness. Conclusion Exploring illness representations is a key step that can help health professionals to get an integrated perspective that could be useful in designing and calibrating interventions according to specific patient needs.
Mid- to long-term outcome of reverse total shoulder arthroplasty as revision procedure for failed hemiarthroplasty after proximal humerus fracture
Authors: Paksoy Alp , Akgün Doruk , Imiolczyk Jan-Philipp , Gebauer Henry , Lacheta Lucca , Scheibel Markus , Hayta Agahan , Moroder Philipp 
Published: September 2024

Abstract
Background
Insufficient tuberosity healing is the most common reason for poor outcome after treatment of proximal humerus fractures (PHFs) using hemiarthroplasty (HA). In these cases, revision to reverse total shoulder arthroplasty (RTSA) can improve function and reduce pain in the short term, however, long-term results remain scarce. Aim of this study was to evaluate the clinical and radiological mid- to long-term results in patients with a revision RTSA after failed HA for PHF.

Methods
In this retrospective study all patients that received a revision to RTSA after failed fracture HA between 2006 and 2018 were included. A total of 49 shoulders in 48 patients (38 female, 10 male; mean age 82 ± 9 years) were identified in our database. A total of 20 patients (17 female, 3 male; mean age was 79 ± 9 years) were available for follow-up examination after a mean time period of approximately eight years (3–14 years) after revision surgery. At final follow-up, patients were assessed using a subjective shoulder value (SSV), range of motion (ROM), visual analogue score (VAS), the Constant Score (CS) and the 12-Item Short Form Survey (SF-12).

Results
At final follow-up, mean CS was 55 ± 19 (19–91), VAS averaged 3 ± 3 (0–8) and mean SSV was 61 ± 18% (18–90%). Mean SF-12 was 44 (28–57) with a mean physical component summary (PCS) of 38 (21–56) and a mean mental component summary (MCS) of 51 (29–67). On average active forward flexion (FF) was 104° (10–170°), active abduction (ABD) was 101° (50–170°), active external rotation (ER) was 19° (10–30°) and active internal rotation (IR) of the lumbosacral transition was reached. Three patients presented with a periprosthetic humeral fracture after RTSA implantation and underwent a reoperation (15%) during follow-up period.

Conclusions
Revision RTSA results in promising clinical results in patients after initial failed HA after PHF. A complication and reoperation rate of 15% is tolerable in consideration of satisfactory functional and psychological outcome.

Trial registration
Retrospectively registered.
Next-generation fertilizers: the impact of bionanofertilizers on sustainable agriculture
Authors: Arora Pankaj Kumar , Tripathi Shivam , Omar Rishabh Anand , Chauhan Prerna , Sinhal Vijay Kumar , Singh Amit , Srivastava Alok , Garg Sanjay Kumar , Singh Vijay Pal 
Published: September 2024

AbstractBionanofertilizers are promising eco-friendly alternative to chemical fertilizers, leveraging nanotechnology and biotechnology to enhance nutrient uptake by plants and improve soil health. They consist of nanoscale materials and beneficial microorganisms, offering benefits such as enhanced seed germination, improved soil quality, increased nutrient use efficiency, and pesticide residue degradation, ultimately leading to improved crop productivity. Bionanofertilizers are designed for targeted delivery of nutrients, controlled release, and minimizing environmental pollutants, making them a sustainable option for agriculture. These fertilizers also have the potential to enhance plant growth, provide disease resistance, and contribute to sustainable farming practices. The development of bionanofertilizers addresses the adverse environmental impact of chemical fertilizers, offering a safer and productive means of fertilization for agricultural practices. This review provides substantial evidence supporting the potential of bionanofertilizers in revolutionizing agricultural practices, offering eco-friendly and sustainable solutions for crop management and soil health.
A review of power-to-X and its prospects for integration in Nigeria’s energy transition plan
Authors: Marvin Mahlon Kida , Sarkinbaka Zakiyyu Muhammad 
Published: September 2024

AbstractNigeria currently relies on 80% thermal energy generation. However, studies have shown that less than 60% of the population have access to power. To address this issue, Nigeria has developed an energy transition plan to achieve net-zero emissions by utilizing eco-friendly and sustainable renewable energy sources. However, the effectiveness of renewable energy resources is often hampered by seasonal variations, which limit the amount of energy that can be produced to meet growing demand. One effective solution to this challenge is long-term energy storage, particularly during periods of low demand. Power-to-X (PtX) technology offers a promising approach by enabling long-term sustainable energy generation and storage for future use when renewable energy availability decreases during peak demands. This study critically reviews the latest advancements in renewable PtX technology and evaluates its potential application within Nigeria's energy sector. Furthermore, it explores the potential obstacles to the widespread adoption of PtX technology in Nigeria. Despite Nigeria’s significant potential for implementing PtX initiatives, the country currently falls behind in technology deployment and viable production pathways for sustainable PtX implementation. This shortfall is primarily due to lack of policies, frameworks, and financing schemes to support infrastructural development, especially for long-term energy storage. Given the intermittent nature of renewable energy, a transition strategy that includes adequate storage capacity is crucial. Although green hydrogen, a key component of PtX, has substantial potential as an energy carrier in Nigeria, its immediate use is limited by high production costs. Nonetheless, ongoing efforts to diversify Nigeria’s energy mix through infrastructure and policy developments could eventually establish a roadmap for PtX implementation, promoting long-term energy sustainability and distribution efficiency.
Integrating research evidence into virtual healthcare service programming: a quality improvement analysis of healthcare utilization and series of rapid umbrella reviews
Authors: MacPherson Megan , Khaleghi Roshanak , Rourke Sarah , Ramanaidu Rochelle , Montenegro Maria 
Published: September 2024

Abstract
Background
The integration of virtual solutions in healthcare has shown promise in improving access and reducing strain on hospital services. To maximize impact, healthcare authorities should understand what populations to prioritize in virtual healthcare service deployment as well as the research evidence for virtual care services for those populations. This study aims to support the Fraser Health (FH) Authority in prioritizing the implementation of virtual health, focusing on patient populations that would benefit most. “Patient profiles” were created by analyzing admission, readmission rates, and length of stay based on chronic conditions across FH sites. Using the Pabon Lasso Model for visualization, chronic conditions were categorized into zones to identify those with the greatest acute load. Rapid umbrella reviews were conducted for heart failure, COPD, and diabetes to identify evidence-based virtual care solutions for these high-utilization populations. The resulting knowledge products offered user-friendly, high-level overviews of the evidence for decision-making.

Results
Heart failure, COPD, diabetes, schizophrenia, and anxiety disorders were identified as top chronic conditions with highest acute loads. Rapid umbrella reviews indicated potential benefits of the following virtual care interventions for heart failure, COPD, and diabetes: remote patient monitoring (RPM), eLearning, virtual support (via phone calls or video conferencing), tele-rehabilitation, and text messaging.

Conclusion
Integration of virtual care services has the potential to revolutionize healthcare but requires careful planning and consideration of barriers. Patient profiles and rapid umbrella reviews offer a comprehensive approach to inform prioritization and implementation. RPM, eLearning, virtual support, tele-rehab, and text messaging showed promise for specific chronic conditions.
Stock Market Ownership Transitions
Authors: Bonaparte Yosef , Korniotis George M. , Kumar Alok , Michaelides Alexander , Zhang Yuxin 
Published: September 2024

A significant portion of U.S. households enters and exits investment accounts. Empirically, income and wealth changes are related to these transitions, with income changes not affecting the retired. A life cycle model with participation costs cannot match the observed ownership dynamics, but an extension with stock market crash better fits the average participation rate and ownership transitions of the middle-aged and retired. This extended model does not match the ownership dynamics of the young, which are better captured by a model with elevated income risk. Overall, these findings indicate that ownership transitions respond to wealth shocks across the life cycle, both in our model and the data. This paper was accepted by Victoria Ivashina, finance. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2023.00290 .
The Short-Term Effects of Generative Artificial Intelligence on Employment: Evidence from an Online Labor Market
Authors: Hui Xiang , Reshef Oren , Zhou Luofeng 
Published: September 2024

Generative artificial intelligence (AI) holds the potential to either complement workers by enhancing their productivity or substitute them. We examine the short-term effects of the recently released generative AI models (ChatGPT, DALL-E 2, and Midjourney) on the employment outcomes of freelancers on a large online platform. We find that freelancers in highly affected occupations suffer from the introduction of generative AI, experiencing reductions in both employment and earnings. We find similar effects studying the release of other image-based generative AI models. Exploring the heterogeneity by freelancers’ employment history, we do not find evidence that high-quality service, measured by their past performance and employment, moderates the adverse effects on employment. In fact, we find suggestive evidence that top freelancers are disproportionately affected by AI. These results suggest that generative AI may transform the role of human capital in the organization and reduce overall demand for workers. Supplemental Material: The online appendices are available at https://doi.org/10.1287/orsc.2023.18441 .
Subtexts of Most Read Articles on Social Sciences Citation Index: Trends in Educational Issues
Authors: Köybaşı Şemin Fatma 
Published: September 2024

Abstract
Although education is mostly the duty of educators, it is an important field that concerns all segments of society. Studies and regulations on education on a global scale have gained momentum in terms of increasing both quality and quantity. Which issues related to education are considered important and which problems are focused on can be a guide in giving direction to the regulations in education. In this study, a total of 351 articles published in SSCI journals are reviewed, with documentary analysis, and the subject areas of the most read articles on education are discussed. The most-read articles on education focus on the themes of inequality and injustice in critical education. Other results of the research are discussed in detail in the article.
Thermodynamics and dynamic stability: extended theories of heat conduction
Authors: Somogyfoki Réka , Famá Alessio , Restuccia Liliana , Ván Peter 
Published: September 2024

Abstract
The stability of homogeneous thermodynamic equilibrium is analyzed in heat conduction theories in the framework of nonequilibrium thermodynamics, where the internal energy, the heat flux and a second order tensor are thermodynamic state variables. It is shown, that the thermodynamic conditions of concave entropy and nonnegative entropy production can ensure the linear stability. Various special heat conduction theories, including Extended Thermodynamics, are compared in the general framework.
Selected open problems in continuous-time quantum walks
Authors: Coutinho Gabriel , Guo Krystal 
Published: September 2024

Abstract
Quantum walks on graphs are fundamental to quantum computing and have led to many interesting open problems in algebraic graph theory. This review article highlights three key classes of open problems in this domain: perfect state transfer, instantaneous uniform mixing, and average mixing matrices. In highlighting these open problems, our aim is to stimulate further research and exploration in this rapidly evolving field.
Thermal performance of teardrop pin fins and zig zag ribs in a wedge channel
Authors: Venkatesh Goveraiahgari , Meenakshi Reddy Reddygari 
Published: September 2024

Abstract
Aviation, marine propulsion, and power generation employ gas turbine engines extensively. The combustion process’s high temperatures make gas turbine engine development difficult. For safe turbine blade operation, internal cooling is essential. Ribs, pin-fins, and impinging jets are just examples of the several different types of structures that are typically included in internal cooling systems. The present study investigates the effect of rib placed in between the pin fins in a wedge channel. Nine rib configurations along with base line model without ribs are employed in this study. The SST k-omega turbulence model was employed to simulate the flow field and heat transfer of each case using the commercial software ANSYS Fluent. The investigation demonstrated that the heat transfer distribution and flow field in pin-fin arrays were substantially influenced by the ribs-induced secondary flows, particularly in the spanwise direction, which resulted in a significant heat transfer variation. In comparison to other configurations, the 4H4L rib configuration exhibits the highest thermal performance factor, surpassing the baseline by approximately 16.6 %.