bluuebunny/crossref_metadata_2025_split huggingface dataset:
NOVEL FINDINGS ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH TUBERCULAR SERPIGINOUS-LIKE CHOROIDITIS
Authors: Mandadi Spoorti Krishna Reddy , Agarwal Aniruddha , Aggarwal Kanika , Moharana Bruttendu , Singh Ramandeep , Sharma Aman , Bansal Reema , Dogra Mangat R. , Gupta Vishali ,   for OCTA Study Group
Published: December 2016

Purpose:
To analyze and describe the imaging characteristics of tubercular serpiginous-like choroiditis using optical coherence tomography angiography (OCTA) and to compare these findings with multimodal imaging.

Methods:
In this prospective cross-sectional study, multimodal imaging was performed in subjects with tubercular serpiginous-like choroiditis using OCTA (Optovue RTVue XR Avanti), enhanced-depth imaging OCT (Heidelberg Spectralis), fundus autofluorescence, fluorescein angiography, and indocyanine green angiography. Distinct morphologic features of the retinochoroidal vasculature at the sites of choroiditis lesions were analyzed on OCTA imaging. Multimodal imaging analysis was performed to study the changes observed on OCTA.

Results:
Eighteen eyes (18 subjects, 16 males) were included in the study. The en face OCTA images demonstrated discrete areas of flow void beneath the retinal pigment epithelium–Bruch membrane layer suggestive of choriocapillaris hypoperfusion that corresponded well with indocyanine green angiography, especially in the chronic phase. Additional information such as areas of preserved choriocapillaris, vascular tufts, and tangled vessels were observed using OCTA among lesions in advanced stages of healing. Compared with indocyanine green angiography, the areas of choriocapillaris atrophy appeared better defined on OCTA and correlated well with enhanced-depth imaging OCT.

Conclusion:
The OCTA images provide high-resolution structural information of the retinochoroidal vasculature in tubercular serpiginous-like choroiditis. Morphologic information obtained from OCTA images correlates well with and supplements other imaging techniques such as indocyanine green angiography and enhanced-depth imaging OCT.
CASE OF METASTATIC UROTHELIAL CARCINOMA OF THE RETINA AND VITREOUS
Authors: Whalen Katherine E. , Eagle Ralph C. , Vrabec Tamara R. 
Published: December 2016

Purpose:
To report a rare case of vitreo-retinal metastasis from urothelial carcinoma of the bladder.

Methods:
Case report.

Results:
A 55-year-old man with a history of bladder cancer developed atypical vitritis and a white fundus mass. Intravenous fluorescein angiography demonstrated connection between the retinal and tumor vasculature consistent with a retinal malignancy. Cytologic analysis of the vitreous sample revealed large, atypical cells with pleomorphic nuclei, mucin vacuoles, and rare mitotic figures. The cells were immunoreactive for cytokeratin markers AE1/AE3, CK7, and CK20 and the urothelial carcinoma marker GATA3. Review of the patient's initial bladder tumor revealed an anaplastic epithelial neoplasm with dyscohesive cells that appeared histologically identical to those in the vitreous biopsy. Despite external beam radiation therapy, the patient's vision declined and the eye became painful and was ultimately enucleated.

Conclusion:
Retinal metastasis from systemic adenocarcinoma is an extremely rare occurrence with poor prognosis for vision.
RETINAL FINDINGS IN A CASE OF PRESUMED CUTIS MARMORATA TELANGIECTATICA CONGENITA
Authors: Taleb Eman A. , Nagpal Manish P. , Mehrotra Navneet S. , Bhatt Kalyani 
Published: December 2016

Purposes:
To correlate the clinical picture and fundus fluorescein angiography findings in case of presumed cutis marmorata telangiectatica congenita.

Methods:
A 41-year-old woman with presumed cutis marmorata telangiectatica congenita who is a known case of hypothyroidism for the last 6 years and has bilateral peripheral retinal vascular abnormalities, peripheral retinal nonperfusion on fluorescein angiography and bilateral optic disk drusen.

Result:
A patient presented with blurring of vision in both eyes for last 6 months. On examination, livedo reticularis skin lesions in both upper and lower extremities were noted. Best-corrected visual acuity in the right eye was 6/18 and left eye was 6/36. Slit-lamp examination revealed posterior subcapsular cataract in the right eye. Fundus examination showed bilateral optic disk drusen, tortuous blood vessels, and peripheral fan-shaped sclerosed neovascularization. Fundus fluorescein angiography showed peripheral retinal nonperfusion. She underwent peripheral laser photocoagulation of the left eye and cataract surgery in the right eye. After 2 years of follow-up, her best-corrected visual acuity was 6/9 in both eyes. Her fundus examination and fundus fluorescein angiography findings were stable in both eyes.

Conclusion:
Presumed cutis marmorata telangiectatica congenita is a rare cutaneous vascular disorder that can manifest with nonprogressive retinal vascular abnormality and optic disk drusen.
Prazosin in Children and Adolescents With Posttraumatic Stress Disorder Who Have Nightmares
Authors: Akinsanya Adefolake , Marwaha Raman , Tampi Rajesh R. 
Published: December 2016

Abstract

Background
The aim of this systematic review was to identify published articles that evaluated the use of prazosin for treating nightmares in children and adolescents who have posttraumatic stress disorder (PTSD).

Procedures
A literature search was conducted of PubMed, MEDLINE, EMBASE, Cochrane Collaboration, and PsycINFO databases for published articles in any language that evaluated the use of prazosin for treating nightmares in the context of PTSD in children and adolescents using the following key words: PTSD, nightmares, prazosin, children, adolescents, trauma, and sleep.

Results
A total of 9 published articles related to the use of prazosin for treatment of nightmares in PTSD in children and adolescents were identified. Six of the 9 articles that met our inclusion criteria were case reports. All of these 6 case reports showed marked improvement in nightmares when prazosin was used, although at a generally lower dose when compared with its use in adults, with dosing ranging from 1 to 4 mg/d.

Conclusions
Prazosin has shown promising outcomes in treating nightmares associated with PTSD in children and adolescents, although this has not been well studied. Future placebo-controlled trials are needed to assess the efficacy and safety of prazosin in treating PTSD-related nightmares in children and adolescents.
Validity and Reliability Study of the Baxter Animated Retching Faces Nausea Scale
Authors: Şişman Hamide , Eti Aslan Fatma , Özgen Refiye , Alptekin Dudu , Akil Yasemin 
Published: December 2016

Aim:
Nausea and vomiting, which are unpleasant clinical problems in the postoperative period, have negative outcomes related to patient satisfaction, morbidity, hospital stay, and medical costs. Nausea and/or vomiting may cause tracheal aspiration when unconscious after anesthesia, rupture of wound site, wound infection, recurrent and severe dehydration, and electrolyte impairments with pediatric surgery patients. It is very important to detect and prevent these clinical problems at an early period. Therefore, it is necessary to objectively assess nausea, which is a subjective perception. The aim of the current study was to discover the validity and reliability of the Baxter Animated Retching Faces (BARF) Nausea Scale among pediatric surgery patients.

Method:
The sample of the study, which was in methodological model, consisted of 82 children aged 7-18 years who were treated at inpatient pediatric surgery clinics. The BARF Nausea Scale is a pictorial nausea scale that rates nausea from neutral (no nausea) to emesis (maximum nausea) with six items and six face expressions that describe each of these items. The scale was developed in the English language and includes assessments based on perceptions; Turkish translation and back-translation procedures were not performed. For the content validity, expert reviews were obtained. While the findings obtained from the study were being evaluated, descriptive statistical methods, the Kolmogorov–Smirnov distribution test, the Mann–Whitney U test, the Kruskal–Wallis test, and Pearson correlation analyses were employed. Cochran's Q test was used to determine the suitability of scale options in theoretically measuring nausea–vomiting.

Findings:
Sixty-one percent of the children aged 7-18 years were male. It was identified that 50% of the children were operated because of gastrointestinal problems, 81.1% of them did not get premedication, 91.5% of them did not use antiemetic medicines, and 41.5% of them started to eat 5-6 hours later after the surgery. It was noted that opinions of all the experts were consistent in terms of content validity and that BARF and the visual analog scale, which was found to be suitable for the Turkish people, could statistically be accepted as equal (Cochran's Q = 9, p = .437).

Result:
In the parallel test in which the visual analog scale and BARF were compared, it was understood that BARF was reliable in assessing nausea and vomiting. In light of these results, it may be suggested that the BARF Nausea Scale was a valid and reliable tool in theoretically measuring nausea–vomiting. It is recommended that the BARF Nausea Scale be used for children over 7 years old to measure nausea after operations.
The Utilization of Hypnosis for Children Recovering From Surgical Procedures
Authors: Edmundson Elizabeth Ellen 
Published: December 2016

Abstract
In the United States, approximately 4 million surgical procedures are performed on children every year. Unfortunately, severe postsurgical pain is common. Patients who still have moderate-to-severe postsurgical pain 1 month after a surgical procedure are at risk for deterioration of their health-related quality of life and the development of chronic postsurgical pain. Despite the magnitude of effects that postsurgical pain can have on a child, it is often inadequately assessed and treated because of the wrong notion that children neither experience or feel pain nor respond to or remember painful experiences to the same degree as adults. PubMed, CINAHL, MEDLINE (R), PsycINFO, and Google Scholar were searched for current research and literature that examine the use of hypnosis to manage pain for children undergoing surgical procedures during their postoperative recovery period. Although the literature supports a paucity of hypnosis research in children undergoing surgical procedures, four studies were found suggesting that hypnosis may be an effective tool to decrease postsurgical pain for children. The current state of the science leaves many opportunities to improve on the postoperative pain management strategies for children recovering from surgical procedures.
Otolith Dysfunction in Persons With Both Diabetes and Benign Paroxysmal Positional Vertigo
Authors: D'Silva Linda J. , Staecker Hinrich , Lin James , Maddux Christy , Ferraro John , Dai Hongying , Kluding Patricia M. 
Published: December 2016

Objective:
Vestibular dysfunction is a well-recognized complication of type 2 diabetes (DM) that may contribute to increased fall risk. The prevalence of benign paroxysmal positional vertigo (BPPV) is higher in people with DM. The impact of DM on the otolith organs of the vestibular system in people with BPPV is unknown. The purpose of this study was to analyze otolith function using vestibular-evoked myogenic potential (VEMP) tests in people with DM and concurrent BPPV (BPPV + DM), and to examine the relationships between VEMP variables and diabetes-related variables.

Study Design:
Prospective, cross-sectional study.

Setting:
Tertiary academic medical center.

Subjects and Methods:
Participants 40 to 65 years were recruited in four groups: controls (n = 20), people with DM (n = 19), BPPV (n = 18), and BPPV + DM (n = 14). Saccule and utricle function were examined using cervical VEMP (cVEMP) and ocular VEMP (oVEMP), respectively. Diabetes-related variables such as HbA1c, duration of diabetes, and presence of sensory impairment due to diabetes were collected.

Results:
The frequency of abnormal cVEMP responses was higher in the DM (p = 0.005), BPPV (p = 0.003), and BPPV + DM (p <0.001) groups compared with controls. In the participants with diabetes, higher HbA1c levels were correlated with prolonged P1 (p = 0.03) and N1 latencies (p = 0.03). The frequency of abnormal oVEMP responses was not different between groups (p = 0.2).

Conclusion:
Although BPPV and DM may independently affect utricle and saccule function, they do not seem to have a distinct cumulative effect.
Characterization of Neurologic and Ophthalmologic Safety of Oral Administration of Tedizolid for Up to 21 Days in Healthy Volunteers
Authors: Fang Edward , Muñoz Kelly A. , Prokocimer Philippe 
Published: December 2016

Background:
Antibacterials that inhibit protein synthesis may be associated with mitochondrial toxicity, manifested as serious optic or peripheral neuropathy or myelosuppression. Tedizolid is a novel oxazolidinone antibacterial that may have reduced the potential for mitochondrial toxicity.

Study Question:
Based on the results of 2 studies (NCT01623401 and NCT00671814) conducted early in the tedizolid development program, what is the potential for drug-induced optic and peripheral neuropathies with tedizolid treatment?

Methods:
Two phase-1 studies were conducted in healthy volunteers. The first was an open-label study in which subjects received 200 mg of oral tedizolid phosphate once daily for 10 days. The second was a double-blind, placebo- and active-controlled, dose-escalating (multiple-administration) study in which subjects received 200, 300, or 400 mg of oral tedizolid phosphate once daily or 600 mg of oral linezolid twice daily or oral placebo for 21 days. Overall safety and tolerability were assessed, and extensive ophthalmologic and neurologic assessments were performed in both studies.

Results:
In these 2 studies in healthy subjects, tedizolid administered for up to 21 days was not associated with drug-related ophthalmologic or neurologic adverse events. Incidences of adverse events involving the eye or the nervous system were generally low, and no clinically meaningful changes in ophthalmologic or neurologic test results were recorded during either study.

Conclusions:
Using an extensive battery of ophthalmologic tests and detailed neurologic clinical examination, there was no evidence of clinical or subclinical neurologic or ophthalmologic changes suggestive of peripheral or optic neuropathy in healthy volunteers who received therapeutic and supratherapeutic doses of oral tedizolid for periods of up to 21 days.
Performance of Spectrogram-Based Seizure Identification of Adult EEGs by Critical Care Nurses and Neurophysiologists
Authors: Amorim Edilberto , Williamson Craig A. , Moura Lidia M. V. R. , Shafi Mouhsin M. , Gaspard Nicolas , Rosenthal Eric S. , Guanci Mary M. , Rajajee Venkatakrishna , Westover M. Brandon 
Published: December 2016

Purpose:
Continuous EEG screening using spectrograms or compressed spectral arrays (CSAs) by neurophysiologists has shorter review times with minimal loss of sensitivity for seizure detection when compared with visual analysis of raw EEG. Limited data are available on the performance characteristics of CSA-based seizure detection by neurocritical care nurses.

Methods:
This is a prospective cross-sectional study that was conducted in two academic neurocritical care units and involved 33 neurointensive care unit nurses and four neurophysiologists.

Results:
All nurses underwent a brief training session before testing. Forty two-hour CSA segments of continuous EEG were reviewed and rated for the presence of seizures. Two experienced clinical neurophysiologists masked to the CSA data performed conventional visual analysis of the raw EEG and served as the gold standard. The overall accuracy was 55.7% among nurses and 67.5% among neurophysiologists. Nurse seizure detection sensitivity was 73.8%, and the false-positive rate was 1-per-3.2 hours. Sensitivity and false-alarm rate for the neurophysiologists was 66.3% and 1-per-6.4 hours, respectively. Interrater agreement for seizure screening was fair for nurses (Gwet AC1 statistic: 43.4%) and neurophysiologists (AC1: 46.3%).

Conclusions:
Training nurses to perform seizure screening utilizing continuous EEG CSA displays is feasible and associated with moderate sensitivity. Nurses and neurophysiologists had comparable sensitivities, but nurses had a higher false-positive rate. Further work is needed to improve sensitivity and reduce false-alarm rates.
In search of a model explaining organic food purchase behavior
Authors: Rahman Khandoker Mahmudur , Noor Nor Azila Mohd 
Published: December 2016

PurposeThe purpose of this paper is to explore the domain relevance of a comprehensive yet almost overlooked theoretical framework for studying organic food purchase behavior in a global context. This conceptual paper argues that there exists an apparently powerful model in health behavior domain that may readily be brought into organic food purchase behavior research. The paper argues for domain relevance and proposes that Montano and Kasprzyk’s integrated behavior model may readily be used in organic food behavior studies with some relevant modification.Design/methodology/approachThe paper follows an exploratory approach and shows how variables used in the past may be aggregated to the model in question. The challenge is addressed by following both the inductive and the deductive reasoning. Deductive reasoning calls for investigating whether such behavior may be classified as health behavior. Inductive reasoning calls for proving relevance of all the variables in the aforesaid model to the organic food research context.FindingsThe paper concludes that the Montano and Kasprzyk’s model is theoretically relevant to the organic food behavior domain. However, it is observed that the domain-specific operationalization is necessary for further empirical studies.Research limitations/implicationsSince the model was rarely tested empirically in predicting organic food purchase intention, the variable-specific relevance may not warrant the relevance of the whole model with intertwined relationships at the same time.Practical implicationsThe paper may pave a way toward further empirical research and may also explain the apparent intention-behavior gap as often reported in literature.Originality/valueThe paper may provide a useful direction in future organic food purchase behavior studies by showing the domain relevance of an apparently powerful model, along with addition of some newer variables that may enrich the existing model.
Information sharing and its integrative role
Authors: Watabaji Mulugeta D. , Molnar Adrienn , Weaver Robert D. , Dora Manoj K. , Gellynck Xavier 
Published: December 2016

Purpose
The purpose of this paper is to describe the volume and quality of information and communication channel use at various stages of the malt barley value chain (MBVC) in Ethiopia and to investigate how metrics of these variables influence the extent of integration of the chain.

Design/methodology/approach
The study is based on survey data collected from 320 farmers and 100 traders and interview responses compiled from 76 respondents. Descriptive statistics and ordered logistic regression were used for data analysis.

Findings
The descriptive statistics show a lower volume and poor quality of information is being shared at farmer-trader interface and that value chain integration (VCI) is weak at all studied interfaces. Results of ordered logistic regression show that information volume and quality positively influence VCI, whereas a positive relationship between channel use and VCI was found only at farm level interfaces. Evidences found suggested that inconsistent information systems, lack of information sharing plans, low level of members’ awareness about the value of information, and lack of trust to share information were factors that inhibited information sharing in the MBVC.

Originality/value
The study offers pioneering evidence of the relative role of information volume and quality and channel use as factors that influence the extent of integration of the value chain.
Developing mobile services
Authors: Rivera Manuel , Croes Robertico , Zhong YunYing 
Published: December 2016

Purpose
This paper aims to examine and identify important attributes for mobile applications (apps) that might dictate tourist preferences for the apps on a small island destination. Guided by the Task Technology Fit (TTF) theory, the study considers the tasks performed, technology characteristics and individuals’ characteristics in determining the mobile apps attribute set.

Design/methodology/approach
This study uses a conjoint methodology within a case study approach framework. The conjoint analysis allows for assessing preferences from different consumers regarding the objective characteristics of products or services that facilitate the optimal design of product development. Optimal product development is a challenge for destinations, as they strive to achieve and sustain optimal market positions. Mobile apps may empower destinations in this endeavor. The case study approach imparts a context-dependent knowledge that facilitates a more nuanced understanding of consumer preference of use.

Findings
The results of the conjoint analysis suggest a strategic mapping of the most important attributes including type of content information, coupons and location awareness in defining apps product development. Within each attribute, the study also identifies the significant characteristics of a mobile application that are preferred by tourists. This ranking exists irrespective of familiarity with the destination (first-time and repeat visitors).

Research limitations/implications
The implication is that revealed preferences anchored in conjoint analysis provide a powerful approach to optimize product development in a small island destination. From a practical perspective, the findings suggest that the developments of a mobile app for a destination must concentrate on fostering spending and consider the app as a new marketing channel. From a theoretical point of view, the current study highlights the usefulness of using the conjoint analysis and the TTF theory as an overarching framework in mapping a multi-attribute decision-making space that influences tourist judgment and preference of use. The conjoint method applied in the study enables researchers to clearly identify a combination of various mobile app attributes that are most influential on tourists’ choice and preference of use. The guiding framework, TTF theory, allows the conjoint product designs to go beyond the technology characteristics to include tasks performed by tourists and their individual characteristics.

Originality/value
This study is the first to apply a conjoint analysis within the TTF theoretical framework in the context of a small island destination when assessing tourists’ use preferences toward mobile applications, while at the same time investigating whether any differences exist between first-time and repeat visitors. The study demonstrates that complementing the nature of the task (traveling) with context-specific interface and interactive features is an important area of inquiry that can benefit from adopting conjoint analysis.