bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revolutionizing Antiviral Therapeutics: In silico Approaches for Emerging and Neglected RNA Viruses
Authors: Sharma Kirti , Singh Manjinder , Sharma Sumesh C. 
Published: September 2024

:
The 21st century has shown us how rapidly the pandemic can evolve and devastate the life of human
beings without differentiating between the continents. Even after the global investment of billions of dollars
into the healthcare sector, we are still lacking multiple therapeutics against emerging viruses. World
Health Organization (WHO) has listed a number of viruses that could take the form of pandemics at anytime,
depending upon their mutations. Among those listed, the SARS-CoV, Ebola, Zika, Nipah, and Chikungunya
virus (CHIKV) are the most known viruses in terms of their number of outbreaks. The common feature among
these viruses is their RNA-based genome. Developing a new therapeutic candidate for these RNA viruses in a
short period of time is challenging. In silico drug designing techniques offer a simple solution to these problems
by implementing supercomputers and complicated algorithms that can evaluate the inhibition activity of
proposed synthetic compounds without actually doing the bioassays. A vast collection of protein crystal structures
and the data on binding affinity are useful tools in this process. Taking this into account, we have summarized
the in silico based therapeutic advances against SARS-CoV, Ebola, Zika, Nipah, and CHIKV viruses
by encapsulating state-of-art research articles into different sections. Specifically, we have shown that computer-
aided drug design (CADD) derived synthetic molecules are the pillars of upcoming therapeutic strategies
against emerging and neglected viruses.
Transcriptomic Landscape of Colorectal Mucinous Adenocarcinoma has Similarity with Intestinal Goblet Cell Differentiation
Authors: Liu Jianbo , Qiu Siyuan , Fu Xiaorui , Zhou Bin , Zu Ruijuan , Lv Zhaoying , Li Yuan , Yang Lie , Zhou Zongguang 
Published: September 2024

Introduction:
Colorectal mucinous adenocarcinoma (MC) differs from adenocarcinoma
(AD) in clinical features and molecular characteristics. The current treatment of colorectal MC
is not precise enough, and the molecular characteristics remain unclear. The study aims to explore
the difference between colorectal MC and AD on the transcriptome level for the possibility of
treating colorectal MC precisely.

Methods:
The data of colorectal cancer (CRC) patients from The Cancer Genome Atlas (TCGA)
database was assessed, and then differential analysis and weighted gene co-expression network
analysis (WGCNA) were performed to identify the differential hub RNAs between colorectal MC
and AD. Differential hub lncRNAs and hub RNA of significant modules were validated by quantitative
real-time PCR (qRT-PCR) among different colon cancer cell lines.

Results:
In total, 1680 differential expressed RNAs (DERs) were found by comparing colorectal
MC (52, 13.3%) with AD (340, 86.7%). Through the WGCNA, a mucin-associated RNA module
was identified, while some others might be associated with unique immune progress. Finally, 6 differential
hub RNAs in the mucin-associated RNA module (CTD-2589M5.4, RP11-234B24.2,
RP11-25K19.1 and COLCA1) were validated by qRT-PCR and showed higher expression levels
in mucin-producing colorectal cell lines (Ls174T and HT-29).

Conclusion:
This study suggests that clinical treatments for colorectal MC should be differentiated
from AD. Further exploration of enterocyte (goblet cell) differentiation with tumor genesis and
the distinct immune progression of MC may help to identify key therapeutic targets for colorectal
MC. Further research on the application of immunotherapy to colorectal MC is needed.
Unveiling the Emerging Role of Klotho: A Comprehensive Narrative Review of an Anti-aging Factor in Human Fertility
Authors: Kumar Naina 
Published: September 2024

:
Klotho, an anti-aging protein, plays a vital role in diverse biological functions, such as
regulating calcium and vitamin D levels, preventing chronic fibrosis, acting as an antioxidant and
anti-inflammatory agent, safeguarding against cardiovascular and neurodegenerative conditions,
as well as exerting anti-apoptotic, anti-senescence effects. Additionally, it contributes to metabolic
processes associated with diabetes and exhibits anti-cancer properties. This protein is commonly
expressed in organs, such as kidneys, brain, pancreas, parathyroid glands, ovaries, and testes. Recent
research has highlighted its significance in human fertility. This narrative review provides insight
into the involvement of Klotho protein in male and female fertility, as well as its potential
role in managing human infertility in the future.

:
In this study, a search was conducted on literature spanning from November 1997 to June 2024
across multiple databases, including PUBMED, SCOPUS, and Google Scholar, focusing on
Klotho proteins. The search utilized keywords, such as “discovery of Klotho proteins,” “Biological
functions of Klotho,” “Klotho in female fertility,” “Klotho and PCOS,” “Klotho and cryopreservation,”
and “Klotho in male infertility.” Inclusion criteria comprised full-length original or
review articles, as well as abstracts, discussing the role of Klotho protein in human fertility, published
in English in various peer-reviewed journals. Exclusion criteria involved articles published
in languages other than English. Hence, due to its anti-aging characteristics, Klotho protein presents
potential roles in male and female fertility and holds promising prospects for reproductive
medicine. Further, it holds the potential to become a valuable asset in addressing infertility concerns
for both males and females.
Recent Advances in the Glycolytic Processes Linked to Tumor Metastasis
Authors: Qiong Luo , Shuyao Xiao , Shan Xu , Qian Fu , Jiaying Tan , Yao Xiao , Hui Ling 
Published: September 2024

:
The main cause of cancer-related fatalities is cancer metastasis to other body parts, and increased glycolysis is crucial for cancer cells to maintain
their elevated levels of growth and energy requirements, ultimately facilitating the invasion and spread of tumors. The Warburg effect plays a
significant role in the advancement of cancer, and focusing on the suppression of aerobic glycolysis could offer a promising strategy for anti-cancer
treatment. Various glycolysis processes are associated with tumor metastasis, primarily involving non-coding RNA (ncRNAs), signaling pathways,
transcription factors, and more. Various categories of noncoding RNAs, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and
circular RNAs (circRNAs), have shown promise in influencing glucose metabolism associated with the spread of tumors. Additionally, circular
RNAs (circRNAs) and long non-coding RNAs (lncRNAs) predominantly act as competitive endogenous RNAs (ceRNAs) by sequestering
microRNAs, thereby modulating the expression of target genes and exerting significant influence on the metabolic processes of cancerous cells.
Furthermore, the process of tumor metastasis through glycolysis also encompasses various signaling pathways (such as PI3K/AKT, HIF, Wnt/β-
Catenin, and ERK, among others) and transcription factors. This article delineates the primary mechanisms through which non-coding RNAs,
signaling pathways, and transcription factors contribute to glycolysis in tumor metastasis. It also investigates the potential use of these factors as
prognostic markers and targets for cancer treatment. The manuscript also explores the innovative applications of specific traditional Chinese
medicine and clinical Western medications in inhibiting tumor spread through glycolysis mechanisms, offering potential as new candidates for
anti-cancer drugs.
Sensing In Exergames for Efficacy and Motion Quality: Scoping Review of Recent Publications
Authors: Dill Sebastian , Müller Philipp Niklas , Caserman Polona , Göbel Stefan , Hoog Antink Christoph , Tregel Thomas 
Published: September 2024

Background
Many studies have shown a direct relationship between physical activity and health. It has also been shown that the average fitness level in Western societies is lower than recommended by the World Health Organization. One tool that can be used to increase physical activity for individual people is exergaming, that is, serious games that motivate players to do physical exercises.

Objective
This scoping review of recent studies regarding exergame efficacy aims to evaluate which sensing modalities are used to assess exergame efficacy as well as motion quality. We also analyze how the collected motion sensing data is being leveraged with respect to exergame efficacy and motion quality assessment.

Methods
We conducted 2 extensive and systematic searches of the ACM Digital Library and the PubMed database, as well as a single search of the IEEE Xplore database, all according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. Overall, 343 studies were assessed for eligibility by the following criteria: The study should be peer-reviewed; the year of publication should be between 2015 and 2023; the study should be available in English or German; the study evaluates the efficacy of at least 1 exergame; sensor data is recorded during the study and is used for evaluation; and the study is sufficiently described to extract information on the exergames, sensors, metrics, and results.

Results
We found 67 eligible studies, which we analyzed with regard to sensor usage for both efficacy evaluation and motion analysis. Overall, heart rate (HR) was the most commonly used vital sign to evaluate efficacy (n=52), while the Microsoft Kinect was the most commonly used exergame sensor (n=26). The results of the analysis show that the sensors used in the exergames and the sensors used in the evaluation are, in most cases, mutually exclusive, with motion quality rarely being considered as a metric.

Conclusions
The lack of motion quality assessment is identified as a problem both for the studies and the exergames themselves since incorrectly executed motions can reduce an exergame’s effectiveness and increase the risk of injury. Here we propose how to use the same sensors both as input for the exergame and to assess motion quality by presenting recent developments in motion recognition and sensing.
Bridging Ethics and Education: Crafting Solutions to Address the Threads of Bullying in Indonesia
Authors: Marhaendra Gregory Yehezkiel 
Published: September 2024

Bullying in educational settings has become a significant global issue, exacerbated by the rise of cyberbullying and juvenile delinquency, particularly in Indonesia. The study employs a qualitative approach and literature review to investigate the impact of the curriculum on shaping ethical values and character among students. By focusing on ethical education, particularly the principles of individualism and collectivism, and incorporating deontological and virtue ethics, this research proposes a holistic strategy for addressing bullying. It argues that understanding and integrating these ethical dimensions into school curricula can foster a supportive environment that mitigates bullying and promotes moral development. Additionally, the study underscores the importance of moral philosophy in healing the trauma caused by bullying. It advocates applying ethical principles such as justice, compassion, and empathy to support affected students, helping them overcome trauma and build resilience. The study advocates for applying moral philosophies to help students navigate complex social dynamics, thereby enhancing their emotional well-being and contributing to a more empathetic and just educational environment.
EFFORTS TO PREVENT THE SPREAD OF COVID-19 ACCORDING TO THE DOCTRINE OF MUHAMMADIYAH IN INDONESIA: HADITH STUDIES
Authors: Rohmansyah Rohmansyah , Hidayat Yayat 
Published: September 2024

COVID-19 has emerged as the global challenge confronting the community. The Indonesian government and Muhammadiyah have been engaged in efforts to mitigate the ongoing transmission of COVID-19. Diverse strategies have been employed to combat this disease and prevent its spread and fatalities. This study aims to examine and explain Muhammadiyah’s preventive efforts in Indonesia to combat COVID-19, drawing upon an interpretation of hadiths from the Prophet. A qualitative method was employed to address this issue with a historical, sociological approach to investigate the social conditions during the time of the Prophet and their prevention in relation to contemporary times performed by Muhammadiyah. The study revealed that Muhammadiyah has addressed community and humanitarian issues by implementing efforts to prevent the spread of COVID-19. One such effort was restricting worship activities in mosques and encouraging people to perform them at home until the situation returned to normal. However, in areas deemed safe from COVID-19, worship could still be conducted in mosques while adhering to health protocols such as maintaining social distance, wearing masks, and practicing proper hand hygiene. Furthermore, learning in large group settings has been limited, leading to a shift toward remote online learning from home. Engaging in outdoor muamalah activities, such as working, meetings, religious studies, shopping, and other activities that attract and result in big gatherings, has also been restricted. These efforts aim to disrupt the transmission of COVID-19 as a manifestation of societal care, guided by the teachings of the Prophet as recorded in the hadiths.
Несомненные достижения и легкие укусы (рецензия на том 4 «Археологии Волго-Уралья»)
Authors: Кренке Николай Александрович 
Published: September 2024

Рецензируемая книга – это четвертый том семитомного издания «Археология Волго-Уралья» – труд энциклопедического характера, в котором проанализированы материалы эпохи переселения народов в интервале II – IX вв. н.э. в пределах региона от Кубани до верхней Камы, и от р. Цны до Уральских гор. Главы написаны коллективом из 32-х авторов, включая археологов, антропологов, лингвиста. В нем впервые собраны под один переплет по единой структуре написанные очерки об археологических культурах указанного региона и сведения об отдельных опорных памятниках. В издании сохранены дискуссионные моменты, касающиеся интерпретации памятников, определения истоков влияний, направления миграций, этно-культурной принадлежности древностей. Замечания касаются употребления и понимания археологических терминов и представления в публикации радиоуглеродных дат.
Automatic Detection and Object Classification of Transport Flow Using Data Remote Sensing and of Geographical Information about Roads
Authors: Тормозов В.С. 
Published: September 2024

В статье предлагается алгоритмическая схема автоматического детектирования и классификации объектов ТП с применением космических снимков сверхвысокого пространственного разрешения и географических OSM-данных дорог на местности. Формулируется постановка задачи. Приводится анализ существующих исследований по рассматриваемой проблеме. Схема построена на основе интерполирующей модели перегонов УДС и нейросетевого метода глубокого машинного обучения для распознавания и классификации объектов. Произведено обучение нейросетевого метода на данных космической съемки. Выполнены оценки эффективности работы, как всей схемы, так и каждого составляющего ее алгоритма на реальных ДДЗ и OSM-данных.
The article proposes an algorithm scheme for automatic detection and classification of TP objects using space images of ultra-high spatial resolution and geographical OSM of road data on the ground. Problem definition is formulated. An analysis of existing studies on the issue is provided. The scheme is built on the basis of interpolating model of MAC overhangs and neural network method of deep machine learning for recognition and classification of objects. The neural network method was trained on space survey data. The performance of both the entire circuit and each of its constituent algorithms on the actual DDS and OSM data have been evaluated.
Sinus» Multi-channel Seismic Station Using a Dual-processor Control and Processing System
Authors: Сенин Л.Н. , Сенина Т.Е. 
Published: September 2024

В статье рассмотрены структура и взаимодействие основных контроллерных модулей 24-канальной сейсмической станции «Синус», разработанной и изготовленной в лаборатории сейсмометрии Института геофизики УрО РАН. В модуле управления и модуле аналого-цифрового преобразования станции применены 8-разрядные микроконтроллеры AVR общего назначения фирмы Atmel Corp., что обеспечило прибору компактность и экономичность, при этом сохранив за ним решение сложных задач управления и расчетов практически в реальном времени. Описанные в статье модули могут послужить основой для дальнейшего совершенствования приборов такого типа.
The article discusses the structure and interaction of the main controller modules of the 24-channel Sinus seismic station, developed and manufactured in the seismometry laboratory of the Institute of Geophysics, Ural Branch of the Russian Academy of Sciences. Atmel Corp. general-purpose 8-bit AVR microcontrollers are used in the control module and the analogto-digital conversion module of the station. This ensured the device was compact and economical, while retaining the solution of complex control and calculation problems in almost real time. The modules described in the article can serve as the basis for further improvement of devices of this type.
"INFORMATION EXPLOSION": INTELLECTUAL MODEL LIKELY SCENARIOS OF ITS DEVELOPMENT
Authors: Гулай А.В. , Зайцев В.М. 
Published: September 2024

Предложена интеллектуальная модель динамики развития «информационного взрыва» как параметрического отображения техногенной катастрофы и представлена интеллектная технология определения траекторий миграции критических параметров аварийно опасного объекта. Обобщенный анализ допустимого уровня угрозы возникновения катастрофы выполняется на основе применения аппарата нечеткой логики, экспертного определения пределов допусков на параметры объекта и расчета функций принадлежности их к областям безаварийного функционирования. Показана возможность прогнозирования момента возникновения «информационного взрыва» и определения резерва времени на предотвращение катастрофы при условии непрерывного контроля динамики изменения указанных функций принадлежности.
The intelligent model of “information explosion” development dynamics is proposed as parametric display of the human-made disaster, and the intelligent technology of determining the trajectories of migrations of critical parameters of dangerous installations is shown. The generalized analysis of the allowed level of disaster origin threat is carried out on the basis of the application of a fuzzy logic apparatus, expert determination of allowed limits for object parameters and calculation of functions of their belonging to fail-safe functioning areas. Possible forecasting of the “information explosion” originating moment and determination of the time reserve for disaster prevention is shown, provided that dynamic changes of the aforesaid membership functions are continuously controlled.
IMPROVING THE EFFICIENCY OF THE INFORMATION-MEASURING AND CONTROL SYSTEM FOR MONITORING AIR POLLUTION IN THE INDUSTRIAL REGION IN TERMS OF ISSUES RELATED TO THE OBJECTIVITY OF THE INFORMATION PROVIDED
Authors: Рыбка Н.А. , Маслова А.А. , Панарин М.В. 
Published: September 2024

Рассмотрена актуальная научно-техническая проблема, связанная с повышением объективности информации, предоставляемой информационно-измерительной и управляющей системой мониторинга загрязнения атмосферного воздуха промышленного региона. Уточнены теоретические положения, служащие основой для формирования алгоритмов циклического опроса газоаналитических сенсоров, распределенных в пределах исследуемого промышленного региона, входящих в состав стационарных постов системы мониторинга атмосферы.
The article deals with an actual scientific and technical problem related to increasing the objectivity of information provided by the information-measuring and control system for monitoring air pollution in an industrial region. The theoretical provisions that serve as the basis for the formation of algorithms for cyclic survey of gasanalytical sensors distributed within the studied industrial region, which are part of the stationary posts of the atmosphere monitoring system, are clarified.
INFLUENCE OF INTERFACE CURVATURE AND SOLUTION NONIDEALITY ON THE HENRY’S LAW CONSTANTS
Authors: Кошоридзе С.И. 
Published: September 2024

Парциальное давление газа, растворенного в воде, зависит от кривизны границы раздела вода-пар в соответствии с формулами Кельвина и Гиббса. Кроме того, вблизи вогнутой поверхности водный раствор несовершенен. Эти факторы обусловливают размерную зависимость констант закона Генри газов, содержащихся в нанопузырьках. В работе предложен метод расчета реальных констант Генри для некоторых газов.
The partial pressure of a gas dissolved in water depends on the curvature of the water-vapor interface according to the Kelvin and Gibbs formulas. In addition, near the concave surface, the water solution is imperfect. These factors cause the size dependence of the Henry’s law constants of gases contained in nanobubbles. The paper proposes a method for calculating the real Henry’s constants for some gases.
INVESTIGATION OF A HYDROMECHANICAL METHOD FOR CLEANING ENRICHED ORE FINES FROM THE SOIL OF THE DEVELOPED SPACE
Authors: ЛИЗУНКИН М.В. , ЛИЗУНКИН В.М. , СИТНИКОВ Р.В. 
Published: September 2024

Предложено инженерно-физическое решение проблемы зачистки обогащенной рудной мелочи с почвы выработанного пространства гидромеханическим способом. Сущность способа заключается в том, что рудная мелочь под воздействием струи воды высокого давления перемещается небольшими объемами на скреперную дорожку и далее транспортируется по ней механическим способом до аккумулирующей выработки. Применение предлагаемого способа гидромеханической зачистки рудной мелочи позволит уменьшить потери отбитой руды и получить экономический эффект от повышения производительности труда и извлечения практически всей ранее отбитой и обогащенной руды.
An engineering and physical solution to the problem of stripping enriched ore fines from the soil of the developed space by a hydro-mechanical method is proposed. The essence of the method is that the ore fines under the influence of a high-pressure water jet are moved in small volumes to the scraper track and then transported along it mechanically to the accumulating production. The use of the proposed method of hydro-mechanical cleaning of ore fines will reduce the loss of broken ore and get an economic effect from increasing labor productivity and extracting almost all previously broken and enriched ore.