bluuebunny/crossref_metadata_2025_split huggingface dataset:
A synthetic review: natural history of amniote reproductive modes in light of comparative evolutionary genomics
Authors: X Maggs 
Published: September 2024

ABSTRACTThere is a current lack of consensus on whether the ancestral parity mode was oviparity (egg‐laying) or viviparity (live‐birth) in amniotes and particularly in squamates (snakes, lizards, and amphisbaenids). How transitions between parity modes occur at the genomic level has primary importance for how science conceptualises the origin of amniotes, and highly variable parity modes in Squamata. Synthesising literature from medicine, poultry science, reproductive biology, and evolutionary biology, I review the genomics and physiology of five broad processes (here termed the ‘Main Five’) expected to change during transitions between parity modes: eggshell formation, embryonic retention, placentation, calcium transport, and maternal–fetal immune dynamics. Throughout, I offer alternative perspectives and testable hypotheses regarding proximate causes of parity mode evolution in amniotes and squamates. If viviparity did evolve early in the history of lepidosaurs, I offer the nucleation site hypothesis as a proximate explanation. The framework of this hypothesis can be extended to amniotes to infer their ancestral state. I also provide a mechanism and hypothesis on how squamates may transition from viviparity to oviparity and make predictions about the directionality of transitions in three species. After considering evidence for differing perspectives on amniote origins, I offer a framework that unifies (i) the extended embryonic retention model and (ii) the traditional model which describes the amniote egg as an adaptation to the terrestrial environment. Additionally, this review contextualises the origin of amniotes and parity mode evolution within Medawar's paradigm. Medawar posited that pregnancy could be supported by immunosuppression, inertness, evasion, or immunological barriers. I demonstrate that this does not support gestation or gravidity across most amniotes but may be an adequate paradigm to explain how the first amniote tolerated internal fertilization and delayed egg deposition. In this context, the eggshell can be thought of as an immunological barrier. If serving as a barrier underpins the origin of the amniote eggshell, there should be evidence that oviparous gravidity can be met with a lack of immunological responses in utero. Rare examples of two species that differentially express very few genes during gravidity, suggestive of an absent immunological reaction to oviparous gravidity, are two skinks Lampropholis guichenoti and Lerista bougainvillii. These species may serve as good models for the original amniote egg. Overall, this review grounds itself in the historical literature while offering a modern perspective on the origin of amniotes. I encourage the scientific community to utilise this review as a resource in evolutionary and comparative genomics studies, embrace the complexity of the system, and thoughtfully consider the frameworks proposed.
Changes in the medial prefrontal cortex metabolites after 6 months of medication therapy for patients with bipolar disorder: A 1H‐MRS study
Authors: Li Haijin , Gao Ju , Song Huihui , Yang Xuna , Li Cai , Zhang Yue , Wang Jiahui , Liu Yitong , Wang Dong , Li Hong 
Published: September 2024

AbstractAimsThe study aimed to assess brain metabolite differences in the medial prefrontal cortex (mPFC) between acute and euthymic episodes of bipolar disorder (BD) with both mania and depression over a 6‐month medication treatment period.MethodsWe utilized 1H‐MRS technology to assess the metabolite levels in 53 individuals with BD (32 in depressive phase, 21 in manic phase) and 34 healthy controls (HCs) at baseline. After 6 months of medication treatment, 40 subjects underwent a follow‐up scan in euthymic state. Metabolite levels, including N‐acetyl aspartate (NAA), glutamate (Glu), and Glutamine (Gln), were measured in the mPFC.ResultsPatients experiencing depressive and manic episodes exhibited a notable reduction in NAA/Cr + PCr ratios at baseline compared to healthy controls (p = 0.004; p = 0.006) in baseline, compared with HCs. Over the 6‐month follow‐up period, the manic group displayed a significant decrease in Gln/Cr + PCr compared to the initial acute phase (p = 0.03). No significant alterations were found in depressed group between baseline and follow‐up.ConclusionThis study suggests that NAA/Cr + PCr ratios and Gln/Cr + PCr ratios in the mPFC may be associated with manic and depressive episodes, implicating that Gln and NAA might be useful biomarkers for distinguishing mood phases in BD and elucidating its mechanisms.
Utilizing sentiment analysis of X data to document the evolution of colorectal surgical innovations: The case of transanal total mesorectal excision
Authors: Weltermann T. , Eltyeb H. , Doggett J. , Brady R. R. W. 
Published: September 2024

AbstractAimThe evolution of the utility of medical social media and its global reach has led to a much greater speed of dissemination of medical innovation, such as transanal total mesorectal excision (TaTME). The acceptability and discussions surrounding such innovations can be followed online. Here, we sought to determine if online discussions over time could match known models of innovation evolution using the example of TaTME since its initial description in 2010.MethodsData on using the X hashtag #TaTME were analysed using the social media analytics tool Brandwatch. Trends in mentions, impressions and reach were highlighted over 13 years (1 May 2010 to 31 July 2023). Each mention's sentiment and emotional connotations were analysed using Brandwatch's natural language processing approach.ResultsWe identified 18 525 mentions of #TaTME by healthcare professionals, reaching over 30.6 million X users. A Gartner's hype‐cycle‐like pattern was identified for mention volume and emotional connotation over time. The majority of mentions had a neutral (84%; n = 15 341) or positive connotation (15%, n = 2675). A peak of negatively connotated mentions was identified surrounding the temporary suspension of TaTME in 2019.ConclusionThis study presents a novel method of monitoring online discussions surrounding new surgical innovations by healthcare professionals based on sentiment analysis of public social media data. Mention volume and emotional connotation were the most accurate parameters closely resembling Gartner's hype cycle.
“Society is the present of teaching”: Teaching as a Phenomenon in Levinas's Unedited Lecture Notes
Authors: Castillo Katja 
Published: September 2024

AbstractIn this paper, Katja Castillo approaches the phenomenon of teaching through an analysis of Emmanuel Levinas's unedited conference notes titled “Les nourritures,” “Les enseignements,” and “L'écrit et l'oral.” Levinas's thinking prior to the publication of his major works provides an entry point to his philosophy. In this light Castillo interprets his conference notes as laying the groundwork for the argument he develops later in Totality and Infinity. Drawing on the notes, she describes the phenomenon of teaching as a place to bracket subjective freedom in order to let the other call it into question. The phenomenon of teaching serves as a way to describe the relationship between the same and the other. It is, according to Levinas, a unique interplay between interiority and exteriority, where subjective freedom is intertwined with responsibility to the other, with having to answer to the other. He describes the structure of teaching as characterized by six parts: by being given a past, by reflection, by penetration of freedom, by critical spirit, by transcendence of teaching, and as true symbolism. Following the discussion of Levinas's early writings, Castillo returns to his first major work, Totality and Infinity published in 1961, with the intention of examining the evolution of his phenomenological attitude over time. This approach reveals that Levinas's engagement in formulating a philosophy of education was more robust than previous research has indicated.
Comparable Results Between 8 and 12 Gray TBI in Combination With Fludarabine and Post‐Transplant Cyclophosphamide in MRD‐Negative but Not in MRD‐Positive Acute Lymphoblastic Leukemia Patients Transplanted in First Complete Remission
Authors: Steiner Normann , Massoud Radwan , Richter Johanna , Perekhrestenko Tetiana , Gagelmann Nico , Niederwieser Christian , Rathje Kristin , Lastovytska Iryna , Schäfersküpper Mathias , Heidenreich Silke , Rudolph Ina , Zeck Gaby , Janson Dietlinde , Wolschke Christine , Ayuk Francis Ayuketang , Klyuchnikov Evgeny , Kröger Nicolaus 
Published: September 2024

ABSTRACTBackgroundThe optimal TBI dose for ALL patients undergoing allogeneic SCT is still not clearly defined.MethodsSingle‐center retrospective analysis of high‐risk ALL patients in CR1 treated with 8 Gy (n = 22) or 12 Gy (n = 50) TBI in combination with fludarabine and PTCy. Median patient age in the 8 Gy TBI cohort was 63 (37–79) and 37 (18–56) in the 12 Gy TBI cohort and median follow‐up time was 21 months (range 1–92).ResultsOS and LFS at 2 years after 8 Gy were 65% and 55% versus 74% and 74% after 12 Gy (p = 0.3 and p = 0.2, respectively). CIR and NRM at 2 years were 27% and 14% after 8 Gy versus 4% and 20% after 12 Gy (p = 0.004 and p = 0.4, respectively). MRD‐positive (+) patients (n = 26) receiving 12 Gy (n = 19) showed better OS (p = 0.01), LFS (p = 0.009), GRFS, lower CIR (p = 0.02), and similar NRM than did MRD+ patients receiving 8 Gy (n = 7). MRD‐negative (−) patients (n = 38) receiving 12 Gy (n = 27) had similar OS, LFS, GRFS, lower CIR, and higher NRM (p = 0.04) than did MRD− patients receiving 8 Gy (n = 11).ConclusionOur study demonstrates that 8 Gy TBI in comparison to 12 Gy TBI results in low NRM but a high relapse rate with similar OS, LFS, and GRFS. In MRD+ high‐risk ALL patients, allogeneic SCT with 12 Gy TBI leads to improved OS, LFS, GRFS, and a low relapse rate. Prospective studies comparing the different treatment regimens with larger MRD patient cohorts are needed to confirm this data.
Exploring amyotrophic lateral sclerosis through the visual system: A systematic review
Authors: Khanna Raoul K. , Catanese Sophie , Mortemousque Geoffroy , Mureau Nicolas , Emond Patrick , Pisella Pierre‐Jean , Blasco Hélène , Corcia Philippe 
Published: September 2024

AbstractBackground and PurposeThe human visual system relies on neural networks throughout the brain that are easily accessible for tests exploring eye structures and movements. Over the past two decades, investigations have been carried out on both afferent and efferent components of the visual system in people with amyotrophic lateral sclerosis (ALS). This approach might represent an innovative biomarker research strategy to better characterise the phenotypic variability of ALS. The purpose of this review was to determine whether exploring the visual system of patients with ALS (pwALS) is an effective strategy.MethodsThe Medline and Web of science databases were searched for studies with terms relating to ALS and vision. Of 1146 references identified, 43 articles were included.ResultsIn this review article, both afferent and efferent components of the visual system were found to be impaired in pwALS in the absence of visual complaint, thereby contributing to the hypothesis that ALS is a multisystem disease with sensory involvement. Of note, some areas of the eye remain unexplored (i.e., tears, and retinal function using electroretinography).ConclusionsAccording to the findings available in the literature, investigating the oculomotor system and exploring the ocular surface could represent two key promising strategies to identify new diagnostic biomarkers in pwALS. Further longitudinal studies are needed to identify relevant indicators of disease progression and response to therapeutic intervention.
Treatment of recurrent aphthous stomatitis with oral roflumilast, a multicenter observational study
Authors: Peñuelas Leal Rodrigo , Bagan Leticia , Grau Echevarría Andrés , Peñuelas Ruiz Jose Amancio , Zaragoza Ninet Violeta , Sánchez Carazo Jose Luis , Pérez Pastor Gemma , Labrandero Hoyos Carolina , Finello Malena , Martínez Fernández Sandra , Blaya Imbernon Daniel , González García Ángel , Pérez Zafrilla Elena , Martí Cabrera Miguel , Bagan Jose 
Published: September 2024

AbstractIntroductionSevere recurrent aphthous stomatitis (RAS) represents a therapeutic challenge because of its impact on the patient's quality of life. Additionally, no approved systemic therapies are available. Roflumilast, a phosphodiesterase‐4 inhibitor, has shown promise in other inflammatory dermatological conditions. This study aimed to assess the characteristics, effectiveness, and safety of roflumilast in treating RAS in routine clinical practice.MethodsThis is a single cohort ambispective observational study conducted in five Spanish centers. Twenty‐two patients with RAS treated with roflumilast participated. Data collection included demographic, clinical, and outcome variables. Statistical analysis compared the outcomes of 12 weeks of roflumilast treatment with a similar prior period without treatment.ResultsDuring treatment with roflumilast, a significant reduction in flare‐ups (88%) and oral ulcers (94%) was observed compared to the untreated period. A reduction in pain (66%) and ulcer duration (63%) was observed. Adverse effects (AEs) occurred in 13 patients, predominantly headache and gastrointestinal disturbances. Most of these were self‐limiting or manageable with dose adjustment. Treatment was withdrawn in three cases, mainly because of AEs.ConclusionsThis study suggests that roflumilast may effectively treat RAS by reducing the number of flare‐ups and ulcers, their duration, and the symptomatology produced by the ulcers. In addition, roflumilast has a good safety profile, is well tolerated at low doses, and does not require close monitoring. These characteristics and its favorable economic profile make roflumilast a promising therapeutic option in this pathology.
Perspective and quality aspects of fermentation in rice milk: effects of bacterial strains and rice variety
Authors: Shiriaev Valerii A. , Lavrentev Filipp V. , Morozova Olga V. , Ashikhmina Mariia S. , Goltsman Liudmila M. , Kondrateva Sofiia A. , Kazantceva Uliana I. , Utkin Roman A. , Arseneva Tamara P. , Iakovchenko Natalia V. 
Published: September 2024

SummaryAlthough fermented dairy products with health benefits are the most popular market, the demand for plant‐based products is rapidly growing. The current study investigates the effect of involving Lactobacillus, Streptococcus, Bifidobacterium and Propionibacterium strains on rice milk fermentation. Rice's milks were characterised in terms of nutritional value. The acidification process, growth of beneficial bacteria, physicochemical alteration and sensory characteristics of fermented beverages produced from the milk of different types of boiled rice were investigated. The results revealed that changes in all these characteristics depend on the bacterial strain and the rice variety. The highest increase in antioxidant activity after fermentation was shown by Bifidobacterium longum B379M, Bifidobacterium bifidum and Propionibacterium freudenreichii subsp. shermanii KM‐186 for Krasnodar, basmati and black rice, respectively. The use of chosen bacteria for red rice milk fermentation led to a decrease in antioxidant activity. The highest values for polyphenol content were for samples fermented by Bacillus coagulans MTCC5856 and Streptococcus thermophilus. The greatest increase in bacterial growth during fermentation was demonstrated by the sample fermented with Lactobacillus delbrueckii subsp. bulgaricus, B. bifidum and P. freudenreichii subsp. shermanii KM‐186. The highest acidification rate values, the most favourable doubling time and the specific growth rate were for samples fermented with L. delbrueckii subsp. bulgaricus, S. thermophilus, Lactobacillus acidophilus H9, B. coagulans MTCC 5856, B. bifidum, P. freudenreichii subsp. shermanii KM‐186 depending on the rice type. Considering all data obtained, including sensory characteristics, the most promising bacteria for fermentation are B. bifidum and B. longum B379M.
Prospective evaluation of the accuracy of duplex scanning with spectral analysis in carotid artery disease
Authors: Zbornikova Vera , Lassvik Claes , Johansson Ingegerd 
Published: September 2024

SummaryProspective evaluation of duplex scanning of the carotid vessels was performed over a 2‐year period in 125 consecutive patients (249 vessels) with transient ischaemic attacks or minor stroke. Defining disease as a stenosis of > 15% reduction of the vessel diameter, with subgroups of 16‐49% stenosis. 50‐99% stenosis and occlusion, the sensitivity obtained was 96%. specificity 93%. and accuracy 94%. With the use of linear multiregression analyses further subgrouping into 50‐75% and 76‐99% stenosis was performed. The best predictive variables were, in decreasing order, peak systolic velocity, late diastolic velocity and the difference between peak systolic and late diastolic velocity in the internal carotid artery. The additional periorbital Doppler examination caused a slight improvement in determination coefficient and diagnostic accuracy.
Critical Periods for Waterlogging Effects on Yield and Grain Components in Sunflower (Helianthus annuus), Soybean (Glycine max) and Sorghum (Sorghum bicolor): A Comparative Study
Authors: Sandoval Miqueas N. , Cirilo Alfredo G. , Paytas Marcelo J. , Zuil Sebastián G. , Izquierdo Natalia G. 
Published: September 2024

ABSTRACTWaterlogging affects a high proportion of cultivated land worldwide. Sunflower, soybean and sorghum growth and yield can be affected differently depending on the moment and duration of waterlogging stress. If stress conditions occur during the critical period for yield potential definition (flowering in, sunflower and sorghum and end of pod formation in soybean) they directly reduce grain number, but if the stress occurs during the grain‐filling period, grain weight would be affected. The aim of this study focuses on determining the effects of the moment and duration of waterlogging stress on the yield and its components in sunflower, soybean and sorghum. This information will be useful to understand the effects of waterlogging on yield and to choose a suitable crop or sowing date based on predicted weather conditions for a certain place. To achieve this objective, four experiments were conducted at the Experimental Station of INTA (Reconquista, Santa Fe, Argentina). The effect of the waterlogging in terms of moment (vegetative, critical and grain‐filling periods) and duration (3, 7 and 10 days) on the three crops was evaluated. Sunflower expressed the most negative impact of waterlogging during the vegetative stages (26, 78 and 98% of yield losses with 3, 7 and 10 days, respectively) while soybean suffered major reductions when the stress occurred during the critical period (5%–17% of yield loses). Sorghum did not express any negative responses for the moments and durations tested. This study suggests that the critical period for a waterlogging event differs, according to crops, from the critical period cited for other stresses. Moreover, the magnitude of the damage will mainly depend on the duration of the event. Further studies are needed to elucidate different physiological responses of the species during waterlogging stress.
Modulation of solid solution in MgxMn1−xAl2xFe2(1−x)O4 spinel ceramics for multifunctional devices
Authors: Xian Yue , Zhou Yang , Chen Jia , Li Wenyuan , Wu Ruifeng , Feng Shuangji , Chang Aimin , Zhang Bo 
Published: September 2024

AbstractSolid solution modulation is an ideal method for combining the advantages of different parent compounds while mitigating their disadvantages. Here, we investigated the thermal sensitivity, magnetic properties, and microwave absorption of MgxMn1−xAl2xFe2(1−x)O4 (0.2 ≤ x ≤ 0.8) spinel solid solution ceramics for application in multifunctional devices. The electrical transport and magnetic properties can be modulated by adjusting the solution ratio. The ceramics exhibit negative temperature coefficient characteristic. The B‐values from 5065–8056 K, suggesting accurate temperature measurements over a wide temperature range. As a type of soft magnetic material, it has a narrow hysteresis loop and high resistivity. Vector network analyzer studies indicate Mg0.2Mn0.8Al0.4Fe1.6O4 could be a candidate for microwave absorption in S‐band. This study successfully extends the applicability of MgxMn1−xAl2xFe2(1−x)O4 ceramics for high‐temperature thermistors and also confirms potential for multifunctional device.
Effect of drying on bioactive compounds in Eugenia uniflora fruit pulp
Authors: Bellaver Mariana , dos Santos Camyla Ribeiro Gonzaga , dos Santos Diniz Freitas Marta , Platt Gustavo Mendes , de Moura Neusa Fernandes 
Published: September 2024

AbstractEugenia uniflora is a tropical species rich in bioactive compounds that are highly sensitive to processing conditions, particularly those involving heat. Drying is a widely used method for preserving fruit pulp which can affect the stability of these bioactive compounds. The aim of this study was to assess the impact of drying at different temperatures on the retention of phenolic compounds and carotenoids present in the pulp of E. uniflora, with the goal of optimizing the drying process to preserve the pulp's quality. The E. uniflora pulp was dried in an oven with air circulation at three temperatures (45, 65, and 85°C). During the drying process, the moisture content and concentration of phenolics, β‐carotene, and lycopene were measured over time. After 260 min of drying, phenolic compounds decreased by 63.97% (45 and 65°C) and by 59.62% (85°C). Carotenoids losses were even more pronounced exceeding 89%, for all temperatures, with β‐carotene reductions of 92.91%, 90.72%, and 91.11%, at 45, 65, and 85°C, respectively. Several well‐established drying models were tested to represent the moisture content over time. Two models exhibited a high adherence to the experimental data. Zero‐order, first‐order, and second‐order degradation models were used to describe the concentrations of phenolic compounds and carotenoids. For total carotenoids, the model that showed the best results was temperature‐dependent. The first‐order model provided the best fit for β‐carotene and lycopene, with high R2 values of 0.9852 (45°C), 0.9776 (65°C), and 0.9681(85°C) for β‐carotene, and 0.9776 (45°C), 0.9715 (65°C), and 0.9659 (85°C) for lycopene. These results indicate that higher temperatures accelerate the degradation of bioactive compounds, following a predictable dynamic that can be optimized through adjustments to the drying process.Practical applicationsThe fruit of Eugenia uniflora contains phenolic and carotenoid compounds with significant nutraceutical potential. However, the production of this fruit is seasonal, necessitating effective preservation methods. Drying, which involves the removal of water from the pulp, is a common procedure aimed at extending the fruit's conservation and shelf life. Despite its benefits, the drying process poses a challenge, as bioactive compounds like phenolic and carotenoids are sensitive to thermal processing. Their degradation during drying can lead to a reduction in the fruit's bioactive potential. Therefore, it is crucial to understand the kinetics of drying and the degradation of these bioactive compounds to optimize the drying process and maximize the fruit's nutraceutical value.