bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid Biomarkers in Alzheimer's Disease
Authors: Zarrouk Amira , Debbabi Meryam , Bezine Maryem , Karym El Mostafa , Badreddine Asmaa , Rouaud Olivier , Moreau Thibault , Cherkaoui-Malki Mustapha , El Ayeb Mohamed , Nasser Boubker , Hammami Mohamed , Lizard Gerard 
Published: May 2017

Background:
There are now significant evidences that lipid metabolism is affected in numerous
neurodegenerative diseases including Alzheimer’s disease. These dysfunctions lead to abnormal
levels of certain lipids in the brain, cerebrospinal fluid and plasma. It is consequently of interest to establish
lipid profiles in neurodegenerative diseases. This approach, which can contribute to identify lipid
biomarkers of Alzheimers' disease, can also permit to identify new therapeutic targets. It was therefore
of interest to focus on central and peripheral biomarkers in Alzheimer's disease.

Methods:
A review of the literature on 148 papers was conducted. Based on this literature, the involvement
of lipids (cholesterol and oxysterols, fatty acids, phospholipids) in Alzheimer's disease has been
proposed.

Results:
Of the 148 references cited for lipid biomarkers for Alzheimer's disease, 65 refer to cholesterol
and oxysterols, 35 to fatty acids and 40 to phospholipids. Among these lipids, some of them such as
24S-hydroxyckolesterol, open up new therapeutic perspectives in gene therapy, in particular. The results
on the very long-chain fatty acids suggest the potential of peroxisomal dysfunctions in Alzheimer's disease.
As for the phospholipids, they could constitute interesting biomarkers for detecting the disease at
the prodromal stage.

Conclusion:
There are now several lines of evidence that lipids play fundamental roles in the pathogenesis
of AD and that some of them have a prognostic and diagnosis value. This may pave the way for
the identification of new therapeutic targets, new effective drugs and / or new treatments.
Knowledge About Chronic Orofacial Pain Among General Dentists of Kermanshah, Iran
Authors: Rezaei Fatemeh , Sharifi Roohollah , Shahrezaee Hamid R. , Mozaffari Hamid R. 
Published: May 2017

Background and Objective:Diagnosis and treatment of chronic orofacial pain are one of the most challenging issues in dentistry. The purpose of this study was to assess the knowledge of general dentists regarding orofacial pain in Kermanshah, Iran.Methods:This cross-sectional study was conducted in 2016 including general dentists of Kermanshah city. A researcher-designed questionnaire was administered to collect demographic data as well as measuring knowledge of the dentists in four sections including etiology, clinical presentations, physical examination, and treatment of chronic orofacial pain. The questionnaire had acceptable validity (content validity > 0.9) and reliability (intraclass correlation coefficient= 0.857 for test re-test; Cronbach’s alpha= 0.72 for internal consistency). The data were analyzed by the SPSS software (ver. 18.0) using Spearman’s correlation coefficient (P< 0.05).Results:There were 121 male (72.9%) and 45 female (27.1%) dentists with mean (SD) age of 40.55 (8.03) years and mean (SD) practice history of 13.28 (8.43) years. Mean (SD) knowledge score was 10.54 (2.36) (maximum possible score= 15). 48.2% of dentists had good knowledge in overall. 48.2% about etiology, 45.2% about clinical presentations, 36.1% about physical examination, and 7.8% about treatment had good knowledge. Knowledge had direct and significant relationship with age (r = 0.179;P= 0.022) and practice history (r = 0.18;P= 0.021).Conclusion:The results showed that the studied dentists did not have enough knowledge about chronic orofacial pain especially in the treatment field. Therefore, it is recommended to implement educational programs to improve their knowledge.
A Study on the Microbiological Status of Mineral Drinking Water
Authors: Aditi Faria Y. , Rahman Shafkat S. , Hossain Md. M. 
Published: May 2017

Introduction:Water-borne diseases constitute a major health burden in Bangladesh. The objective of this study was to assess the overall quality of mineral water samples that obtained from different shops of Dhaka city.Material and Methods:To achieve the above-mentioned objective, methods of heterotrophic plate count (HPC) and total coliform count (TCC) were applied. Moreover, isolated colony from mineral water samples were characterized by using biochemical and antimicrobial susceptibility tests.Results:Different water samples showed different HPC ranged from 1.0×10 to 8.00×102. Antimicrobial sensitivity test of some selected bacteria vizS. intermedius, S. aureus, S. felisandS. Saccharolyticuswere performed. It was observed thatStaphylococcusspp. isolates were susceptible to erythromycin, tetracycline, norfloxacin and ciprofloxacin. Furthermore, a fewStaphylococcusspp. isolates were intermediate resistant to penicillin and oxacillin. However, most of theStaphylococcusspp. isolates were resistant to cefixime.Conclusion:The results indicate that mineral water serves as a reservoir of various bacteria and that people in Dhaka city, who are the consumers of these water, might get diseases. This study emphasizes the need for elaborated microbiological examinations of mineral drinking water commonly used in Dhaka city.
Renal Functional Outcomes after Surgery, Ablation, and Active Surveillance of Localized Renal Tumors: A Systematic Review and Meta-Analysis
Authors: Patel Hiten D. , Pierorazio Phillip M. , Johnson Michael H. , Sharma Ritu , Iyoha Emmanuel , Allaf Mohamad E. , Bass Eric B. , Sozio Stephen M. 
Published: May 2017

Background and objectives
Management strategies for localized renal masses suspicious for renal cell carcinoma include radical nephrectomy, partial nephrectomy, thermal ablation, and active surveillance. Given favorable survival outcomes across strategies, renal preservation is often of paramount concern. To inform clinical decision making, we performed a systematic review and meta-analysis of studies comparing renal functional outcomes for radical nephrectomy, partial nephrectomy, thermal ablation, and active surveillance.

Design, settings, participants, & measurements
We searched MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials from January 1, 1997 to May 1, 2015 to identify comparative studies reporting renal functional outcomes. Meta-analyses were performed for change in eGFR, incidence of CKD, and AKI.

Results
We found 58 articles reporting on relevant renal functional outcomes. Meta-analyses showed that final eGFR fell 10.5 ml/min per 1.73 m2 lower for radical nephrectomy compared with partial nephrectomy and indicated higher risk of CKD stage 3 or worse (relative risk, 2.56; 95% confidence interval, 1.97 to 3.32) and ESRD for radical nephrectomy compared with partial nephrectomy. Overall risk of AKI was similar for radical nephrectomy and partial nephrectomy, but studies suggested higher risk for radical nephrectomy among T1a tumors (relative risk, 1.37; 95% confidence interval, 1.13 to 1.66). In general, similar findings of worse renal function for radical nephrectomy compared with thermal ablation and active surveillance were observed. No differences in renal functional outcomes were observed for partial nephrectomy versus thermal ablation. The overall rate of ESRD was low among all management strategies (0.4%–2.8%).

Conclusions
Renal functional implications varied across management strategies for localized renal masses, with worse postoperative renal function for patients undergoing radical nephrectomy compared with other strategies and similar outcomes for partial nephrectomy and thermal ablation. Further attention is needed to quantify the changes in renal function associated with active surveillance and nephron-sparing approaches for patients with preexisting CKD.
Patient-related beliefs and adherence toward their medications among the adult hypertensive outpatients in Tanzania
Authors: Jande Mary , Katabalo Deogratias M , Sravanam Praveen , Marwa Carol , Madlan Bijal , Burger Johanita , Godman Brian , Oluka Margaret , Massele Amos , Mwita Stanley 
Published: May 2017

The following article has been retracted from Journal of Comparative Effectiveness Research as it did not meet the ethical standards of the Journal and the Universities, owing to the use of an invalidated MMAS-8 scale:
Jande M, Katabalo DM, Sravanam P, Marwa C, Madlan B, Burger J, Godman B, Oluka M, Massele A, Mwita S. Patient-related beliefs and adherence toward their medications among the adult hypertensive outpatients in Tanzania. J. Comp. Eff. Res. 6(3), 185–193 (2017).
The authors and editors of the Journal of Comparative Effectiveness Research regret any negative consequences this publication might have caused in the scientific and medical communities.
Auditor Size and Going Concern Reporting
Authors: Berglund Nathan R. , Eshleman John Daniel , Guo Peng 
Published: May 2017

SUMMARY
Auditing theory predicts that larger auditors will be more likely to issue a going concern opinion to a distressed client. However, the existing empirical evidence on this issue is mixed. We attribute these mixed results to a failure to adequately control for clients' financial health. We demonstrate how properly controlling for clients' financial health reveals a positive relationship between auditor size and the propensity to issue a going concern opinion. We corroborate our findings by replicating a related study and showing how the results change when financial health variables are added to the model. In supplemental analysis, we find that Big 4 auditors are more likely than mid-tier auditors (Grant Thornton and BDO Seidman) to issue going concern opinions to distressed clients. We also find that, compared to other auditors, the Big 4 are less likely to issue false-positive (Type I error) going concern opinions. We find no evidence that the Big 4 are more or less likely to fail to issue a going concern opinion to a client that eventually files for bankruptcy (Type II error). Our results are robust to the use of a variety of matching techniques.
JEL Classifications: M41; M42.
Å kommunisere en konflikt – aktører i RTs dekning av situasjonen i Ukraina i februar–mars 2014
Authors: Østevik Malin 
Published: May 2017

Communicating Conflict: Actors in RT Coverage of the Situation in Ukraine February–March 2014
This article analyses the Russian public diplomacy news organization RT’s coverage of the situation in Ukraine in February–March 2014, the period that culminated with the annexation of Crimea. It finds that enemy images were drawn of the West/USA and of Ukrainian radicals, whereas the liberal opposition and in part the new Ukrainian government were subjected to "symbolic annihilation" – that is they were not represented at all, only indirectly in depictions of the enemy image of the other actors. Locating these portrayals in the theoretical literature on "strategic narratives", the author interprets them as attempts at achieving consensus around Russia’s own perspectives on international affairs, which include the promotion of a world order in which the USA is no longer a hegemon and Russia is respected as a great power.
(Published: May 2017)
Citation: Malin Østevik (2017) «Å kommunisere en konflikt – aktører i RTs dekning av situasjonen i Ukraina i februar–mars 2014», Nordisk Østforum 31 [1], 1–21. http://dx.doi.org/10.23865/nof.v31.579
VERCampus – Live Park of Renewable Energies
Authors: Vicente Leite  , José Batista  , Orlando Rodrigues  
Published: May 2017

This paper presents the VERCampus Project – Live Campus of Renewable Energies – which integrates a set of technologies, infrastructures, and initiatives carried out in the Campus of the Polytechnic Institute of Bragança (IPB) regarding the renewable energies technologies and distributed power generation systems promotion and dissemination for IPB students and for other schools and education levels, stakeholders and all community in general. The aim is to create an attractive and innovative green Campus as a real platform for training, education and dissemination activities in order to understand the real cost of the energy and stimulate better behaviours in view of a rational use of energy. The results consist of an experimental framework based on commercial equipment with new and innovative functionalities developed by students and teaching staff of IPB in view of studies and transfer of practical information and technology for the community. This paper describes the main activities achieved for these purposes and some details are presented.
Modelling and Validation of the Magnetizing Curve to Represent Saturated Core Reactor Using ATP Simulator
Authors: J.A.F. Barbosa Jr  , J. C. Oliveira  , T. V. Silva  , I. N. Gondim  , F. P. Santilio  , L. N. Velasco  
Published: May 2017

This paper is focused on the proposal and validation of a procedure to obtain the necessary data to model the magnetization curve of saturated core reactors as required for the voltage regulator device constituted by a parallel combination of an inductive saturated unit and a fixed capacitor bank. The methodology to model the nonlinear device is based on constructive parameters and information associated to the type of magnetic material utilized to build up the equipment. The results are expressed in terms of the relationship between the core flux and current values which are used to feed the ATPDraw time domain simulator. Computational studies are then carried out to find the reactive power absorbed by the reactor as a function of the applied voltage, and the theoretical results are compared to three prototypes having different ratings. The experimental results derived from 7kVAr-0.22kV, 600kVAr-13.8kV and 3MVAr-34.5kV products are then utilized to validate the saturation curve ATP representation through a comparative performance analysis of the absorbed reactive power with the voltage variation.
Design and Analysis of HT-PEMFC Systems with Different Fuel Processors for Stationary Applications
Authors: S. Authayanun  , M. Mamlouk  , K. Scott  , A. Arpornwichanop  
Published: May 2017

Due to its high CO tolerance,the high-temperature polymer electrolyte membrane fuel cell (HT-PEMFC) has a simpler fuel processing than a low-temperature polymer electrolyte fuel cell (LT-PEMFC) system. In this study, a performance of the HT-PEMFC integrated with a glycerol steam reformer system with/without a water gas shift reactor is examined and compared with the LT-PEMFC system. The HT-PEMFC system shows good performance over the LT-PEMFC system at the operational condition of high current density condition (>6000 A/m2). The presence of high CO concentration is the main problem of operation of HT-PEMFC system without the water gas shift reactor at high current density. At the same time, the LT-PEMFC suffers from CO poisoning and low oxygen concentration at high current density as well. Considering the system efficiency, the HT-PEMFC system with the water gas shift reactor in the glycerol processor shows the highest overall system efficiency.
Sociolingüistica de la elisión de la dental -/d/- en Madrid (Distrito de Salamanca)
Authors: Molina Martos Isabel , Paredes García Florentino 
Published: May 2017

En este artículo se analiza la elisión del fonema dental /d/ en posición intervocálica en Madrid (distrito de Salamanca), con objeto de caracterizar social y lingüísticamente el cambio en su doble tendencia, conservadora en el entorno general e innovadora en el entorno -ado. Se completan y reinterpretan los análisis variacionistas con otros que analizan el aporte individual con el fin de explorar una dimensión que evidencie la agentividad de los hablantes y la naturaleza performativa de la lengua en uso. Mediante análisis de correlaciones y análisis de regresión se analiza la incidencia de 26 variables en la realización del segmento y se atiende al impacto individual de los hablantes en la innovación. Original recibido el: 2014/04/25Dictamen enviado al autor: 2014/06/20Aceptado el: 2014/06/21
Intentional Head Injury: Survivor Victim's Profile, Gender Differences and Role of Alcohol Use at Manipal Teaching Hospital, Pokhara, Nepal
Authors: Atreya Alok , Kanchan T , Karmacharya BG 
Published: May 2017

IntroductionHead is a vulnerable area in human body and also a favorable site for assaults which is easily accessible by assailant's raised arms. ObjectiveThe objective of this study was to evaluate the socio demographic spectrum, severity, radiological findings and outcome of victims assaulted to the head. Furthermore, the study aims to correlate such findings to the role of alcohol use in Nepalese context. MethodologyThis longitudinal prospective study includes victims of traumatic head injury as a result of physical assault who were admitted in the Neurosurgery Unit of Manipal Teaching Hospital Pokhara, Nepal from 1st January to 31st December 2015. ResultsIntentional head injury accounted to 17.40% of all head injury cases admitted during the study period. Among them 48 (76.19%) were males and 15 (23.81%) were females. The minimum age of the patient was 15 years and maximum was 84 years with a mean age of 33.89±14.67 years. Most of the victims of physical assault belonged to the age group of 21 to 30 years. Blunt object was the most commonly used for assault. Loss of consciousness was associated only with 49.21% of cases and 14.29% cases had bleeding from ear and/or nose. More than 75% of the cases had significant radiological finding in the form of fracture and/or intracranial lesion. Majority of the victims during the study were treated conservatively and were discharged with advice. Alcohol use was involved in 36.51% cases of intentional head injuries. ConclusionIntentional injuries under the influence of alcohol use are totally preventable public health concerns. It can be ascertained that reducing availability and improving the environment in which alcohol is sold and consumed can result in a dramatic reduction in violent crimes.Birat Journal of Health Sciences Vol.2/No.1/Issue 2/ Jan - April 2017, Page: 102-105
Laparoscopic Management of Ectopic Pregnancy at Birat Medical College & Teaching Hospital, Morang, Nepal
Authors: Neupane Bhanubhakta , Karki GMS , Dahal P , Karki SB 
Published: May 2017

IntroductionEctopic pregnancy is the most life threatening emergency in first trimester of pregnancy. Laparoscopic methods for treating ectopic pregnancy have made it preferred surgical technique over laparotomy. Most of the ectopic pregnancies can now be treated by laparoscopy.ObjectiveTo study outcome of laparoscopic management of ectopic pregnancy. MethodologyA hospital based cross-sectional study was conducted at Birat Medical College and Teaching hospital from May 2013 to April 2016. The informed consent was taken from patients. The collected data was entered in Microsoft Excel and analyzed SPSS.ResultsAll 89 cases of ectopic pregnancies were managed by laparoscopy. All were tubal pregnancies. Salpingectomy was done in 88 cases and salpingostomy in one case without any significant postoperative complications. There was no maternal mortality and no conversion to laparotomy ConclusionTreatment of ectopic pregnancy by laparoscopy is effective with decreased postoperative morbidity.Birat Journal of Health Sciences Vol.2/No.1/Issue 2/ Jan - April 2017, page: 106-109
Wertsteigerung im Unternehmen durch E-Technologien?
Authors: Wildemann Horst 
Published: May 2017

Kurzfassung
Sich mit Wertsteigerung auseinander zu setzen, wird weitestgehend mit der Erhöhung des Shareholder Value gleich gesetzt. Viele Unternehmen berücksichtigen nicht, dass Wertsteigerung wesentlich durch Stakeholder wie Kunden, Mitarbeiter und Lieferanten beeinflusst wird. Demzufolge sind die Managementpraxis und die Methoden zur Erreichung einer Wertsteigerung auf diese Stellhebel abzustimmen. Informationsverarbeitung, Kooperationsstrategien, Menschenführung, Kernkompetenzen, Generierung und Auswertung von Wissen sowie gezielte Allokation von Beteiligungen sind Maßnahmen und Konzepte, die eine Wertsteigerung aus allen relevanten Perspektiven ermöglichen.
Unternehmensplanung und -steuerung in virtuellen Produktionsmodellen
Authors: Dietel Ulrich , Lang Ralf 
Published: May 2017

KurzfassungMit Kooperationen können kleine und mittelständische Unternehmen (KMU) ihre Flexibilität unter Nutzung der Internet-Technologie in eine langfristige Marktstrategie umsetzten. Auf dieser Grundlage entstehen Kooperationsplattformen zur Realisierung einer weltweiten Marktpräsenz. Träger solcher Plattformen können KMU sein, die, gestützt auf spezifisches Produktwissen, mit der Entwicklung bzw. Weiterentwicklung Ihrer Produkte Folgeprozesse mit generieren und in einem virtuellen Produktionsmodell ablegen. Die Anwendung dieses virtuellen Produktionsmodells auf eine konkrete Marktsituation ermöglicht die schnelle Suche und Bindung geeigneter Kooperationspartner und die Steuerung der sich anschließenden Geschäftsprozesse.
Virtuelle Entwickung via World Wide Web
Authors: Walter Holger 
Published: May 2017

Kurzfassung
Von der Idee bis zum Verkauf eines Produkts entstehen eine Fülle von Daten unterschiedlichster Art und Menge. Diese jederzeit an allen Standorten eines Unternehmens verfügbar zu machen und optimal zu strukturieren, ist die zentrale Herausforderung für Entwicklungsdienstleister in der Automotive- und Fertigungsindustrie. Gerade diese Unternehmen arbeiten an global verteilten Standorten. Für sie ist es daher ein “Muss”, Produktdaten standortübergreifend zu koordinieren. Heute bestimmt der Kunde mit seinen speziellen Ansprüchen sowohl die Produktlebenszyklen als auch die Vielfalt der Produktvarianten. Folglich wird durch verkürzte Innovationszyklen der Marktdruck stärker, effektivere Entwicklungswerkzeuge und IT-Landschaften sind erforderlich. Mittels Internet ist für global agierende Automobilhersteller die Einbindung von Zulieferern und Partnern realisierbar.
CRM entdeckt das Internet
Authors: Klein Christian 
Published: May 2017

Kurzfassung
Customer Relationship Management (CRM) hat sich bereits als ein erfolgreicher Ansatz im Bereich Kundenbindung etabliert. Mit dem so genannten Electronic-Customer Relationship Management zeichnet sich eine aktuelle Tendenz innerhalb des klassischen CRM ab. Dies ist laut Forrester Research ein Web-zentrischer Ansatz, der Kundenkontakte über alle Kommunikationskanäle und Geschäftsfunktionen hinweg intensivieren soll. Dieser Ansatz geht davon aus, dass das Internet eine wichtige Schnittstelle zum Kunden darstellt, die in den nächsten Jahren erheblich an Bedeutung gewinnen wird.
Lactobacillus brevis Lipase: Purification, Immobilization onto Magnetic Florosil NPs, Characterization and Application as a Detergent Additive
Authors: Soleimani Seyedeh Sara , Nadaroglu Hayrunnisa , Kesmen Zulal 
Published: May 2017

Abstract
In this study, a thermo-tolerant and alkaline lipase enzyme was purified from Lactobacillus brevis and immobilized onto modified γ-Fe3O4 florisil nanoparticles (γ-Fe3O4 MF NFs) and the usability of free lipase (FL) and immobilized lipases (IML) as detergent additives was investigated. Lipase enzyme was purified by fractional precipitation using 20% ammonium sulfate, DEAE-Sephadex ion-exchange chromatographic column, and Sephacryl S200 gel filtration chromatographic techniques. Then, the enzyme was purified, which resulted in 135.2-fold purification. Its molecular mass was determined to be 57 kDa by SDS-PAGE. The covalent immobilization of purified lipase was done using γ-Fe3O4 MF NPs. γ-Fe3O4 MF NPs and IML were characterized by using SEM, TEM, FT-IR, and XRD. IML showed a good thermo-stability and its activities were calculated as 80% at 60°C. The free and IML enzymes were most stable at alkaline pHs in the range of 7.0–10.0. Also, IML is more stable towards metal ions compared to free lipase enzyme. Washing performances of some detergent formulations were investigated in the presence and absence of Lipase. Olive oil was removed by the detergent alone and by the detergent and IML at ratios of 45% and 72%, respectively. The study on removal of oil stain from cotton cloths indicated that the removal of oil was superior in the presence of IML and IML with detergent, when compared to the detergent alone.