bluuebunny/crossref_metadata_2025_split huggingface dataset:
Behavioural Asset Pricing: Review and Synthesis
Authors: Chandra Abhijeet , Thenmozhi M. 
Published: January 2017

This article presents an overview of literature on behavioural and experimental asset pricing theory. We systematically review the evolution and current development of behavioural asset pricing models as an alternate approach to asset pricing in financial economics literature. A review and synthesis of research carried out in behavioural finance spreading across theoretical, empirical and experimental approaches are presented to understand the behavioural dimension of pricing of financial assets. From theoretical perspective, behavioural asset pricing models try to adopt additional behavioural variables into asset pricing process. In terms of empirical investigation perspective, it is documented that econometric and computational advancement takes its biggest place ever in financial literature when compared with the other field. Our review underlines the fact that the direction of advancing a methodology is changing from financial literature to economics due to the fact that there is huge account of raw data available to analyze. Future research direction should be judging the empirical power of the asset pricing models and their role in practice for incorporating a new dimension to the model. The distinctiveness of the study is that this is the first attempt to review literature written on behavioural asset pricing models in the form of structural empirical review. In doing so, the historical perspective of the concept and the place it will take in future are clarified and the way further researches will be conducted are explored. JEL: E03, G02, G12
Relational Group Psychotherapy: An Overview: Part I: Foundational Principles and Practices
Authors: Billow Richard M. 
Published: January 2017

By our theories, techniques, personality, and spontaneous behaviour, we define how group relationships, and experiences are to be regarded, and the emotional depth to which exchanges may be considered. In a three-part series, I present an overview of my approach to relationally based group psychotherapy. I assume that the need for ‘truth’, that is, emotional meaning is primary organizer of group formation and process. Individuals and groups cycle through an interactive interplay of mental states, both to seek and avoid truth seeking, Topics introduced in Part I include a brief introduction to relational theory and its historical foundation; the efficacy of combined-individual psychotherapy; the centrality and activity of the therapist; and the description of some key foundational concepts: ‘G’ (urge to group), emotional truth and falsity, interplay of mental categories, basic affects (Bion’s LHK), and passion.
Severe muscle fasciculations and tremor in a cat with hypochloraemic metabolic alkalosis secondary to duodenal obstruction
Authors: Jukes Alison , Gunew Marcus , Marshall Rhett 
Published: January 2017

Case summary An 18-month-old, female spayed, Australian Mist cat presented with a 24 h history of muscle tremors and inappetence progressing to collapse with generalised muscle fasciculations. The cat was diagnosed with a hypochloraemic metabolic alkalosis due to a duodenal foreign body found to be a trichobezoar at coeliotomy. The cat made a complete recovery after enterotomy to remove the trichobezoar, with cessation of neuromuscular clinical signs and normalisation of its electrolyte and acid–base imbalances. Relevance and novel information Muscle fasciculations and tremors in cats can be caused by intoxications, metabolic derangements, encephalomyelitis, feline hyperaesthesia syndrome and cerebellar diseases. The presenting clinical signs of severe muscle fasciculations and tremors have not previously been reported in association with an intestinal obstruction in the cat.
Lower limb fractures associated with multiligament knee injury
Authors: Stagnaro Joaquin , Yacuzzi Carlos , Barla Jorge , Zicaro Juan Pablo , Costa-Paz Matias 
Published: January 2017

Objectives: Knee ligament injuries related to lower limb fractures are common and frequently unnoticed. Management of acute polytrauma is usually focused in the bone lesion and a complete physical examination might be really difficult. The purpose of this study was to analyze a series of patients who suffered multiligament knee injuries associated to a lower limb fracture. Hypothesis: The use of magnetic resonance imaging (MRI) during the initial management can lead to an early diagnosis of ligament injuries. Methods: A retrospective search was conducted from our hospital´s electronic database. We evaluated the initial diagnosis and acute surgical treatment, and management and functional outcomes after the ligament lesion was diagnosed. Results: Seven patients who presented a knee multiligament injury associated with a lower limb fracture were evaluated. The average age was 29 years. Primary diagnoses were: four tibial plateau fractures; one open fracture-dislocation of the knee; one open leg fracture and ipsilateral hip dislocation; and one bifocal femur fracture. Only three patients had an MRI during the initial management of trauma. Six out of seven patients had to be operated on for the multiligament knee injury. The period between the resolution of the fracture and the ligamentous repair was from 3 to 24 months. Conclusion: Poor functional outcomes are reported in patients with multiligament knee injuries associated with high-energy lower limb fractures. We consider an MRI during the initial management can lead to better outcomes. A trauma surgeon working alongside an arthroscopic surgeon might optimize the results for these lesions.
Osteochondral Defects of the Knee treated with Mosaicplasty. Results at Eight Years of Follow-Up
Authors: Zicaro Juan Pablo , Romoli Agustin Molina , Revah Mariano Agustin , Dere Juan Jose , Yacuzzi Carlos , Costa-Paz Matias 
Published: January 2017

Objectives: There are several surgical options described for osteochondral defects of the knee depending on the size, location and condition of subchondral bone. The main indication for a mosaicplasty procedure is a less than 4 cm2 femoral condyle lesion. The purpose of this study was to analyze a series of patients treated with mosaicplasty with average eight years of follow-up. Methods: We retrospectively evaluated sixty-two patients with osteochondral defects of the knee who underwent a mosaicplasty between 2001 and 2014 with a minimum follow-up of 2 years. Patients were evaluated using the Lysholm score, International Knee Documentation Committee Score (IKDC) and Kellgren-Lawrence radiographic scale. Results: The mean Lysholm score was 80.1 and IKDC was 66.7. Forty-two patients had isolated mosaicplasty and 20 patients presented an associated surgical procedure (osteotomy, ACL reconstruction, meniscectomy). There were no significant differences between the Lysholm and IKDC scores in these two groups. Conclusion: We consider that mosaicplasty is a satisfactory procedure with good functional results in patients with focal articular cartilage lesions of the knee.
Labral Healing
Authors: Catan Agustín , Vilaseca Tomas , Arroquy Damián , Carboni Martín , Guiñazú Jorge Eduardo , Orlowsky Belén , Irigoitia Nicolas , Chahla Jorge 
Published: January 2017

Objectives: The purpouse of this study was to evaluate MRI images of labral repair after one year, trying to stablish MRI images as a reliable tool for the diagnosis of labral healing. Methods: One hundred and sixty-two patients presenting with femoroacetabular impingement that underwent an arthroscopic surgery were treated between 2012 and 2015. Of these, 124 met the selection criteria and were included in this study. Only patients with 12 months of follow up and labral repair were included. Patients with previous hip surgery were excluded. Coronal, sagittal and axial MRI cuts were evaluated by three independent observers, an arthroscopic hip surgery, a fellow in hip arthroscopic surgery and a musculoeskeletal radiologist. Results: on regard of our statistics 68% of the patients had labral healing images, 16% had no healing signals and 16% unsatisfactory images. Just in the 47% the observers had a 100% of agreement. Interobserver variation was: intraobserver agreement was 94% ( arthroscopic surgeon), 72 % (radiologist), 67 % (fellow). Conclusion: The main finding of this study was that a high inter and intraobserver variability was found when analysing the healing status of hip repaired labrums. Assessment of labrum healing after an arthroscopic repair should not only rely on imaging methods and therefore should be concurrently performed with a comprehensive physical examination.
Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations
Authors: Hou Tie Zheng , Verma Nisha , Wanders Jennifer , Kennedy Alan , Soskic Blagoje , Janman Daniel , Halliday Neil , Rowshanravan Behzad , Worth Austen , Qasim Waseem , Baxendale Helen , Stauss Hans , Seneviratne Suranjith , Neth Olaf , Olbrich Peter , Hambleton Sophie , Arkwright Peter D. , Burns Siobhan O. , Walker Lucy S. K. , Sansom David M. 
Published: February 2017

Key PointsNew approaches to identifying functionally relevant mutations in CTLA-4 deficiency syndromes. Measuring responses to stimulation and degradation distinguishes between CTLA-4 and LRBA mutations.
Landslide inventory using GISMA techniques.
Authors: Kordouli M. , Kavoura Kat. , Nikolakopoulos K. , Sabatakakis N. 
Published: January 2017

The use of GIS for various types of data is considered to be of high importance, mainly because it is bringing together information from multiple sources. In addition, the new Internet technologies and applications of global world maps, like Google Maps, give the opportunity to build systems that the geographical information can be recorded and administrated by many users from anywhere. This kind of GIS systems is suitable for Business Administration, or Science, or Government Organizations, which need GIS systems with multiple users from many places and multiple kind of information. This system is defined as GISΜΑ (Geographic Information System Multi Administration). In GISMA many users may input the data and use the information from different distance. Each user has specific permissions of use of data as the administrator sets. In this work, the basic principles and rules of a building GISMA system are evaluated and an application is presented based on data and GIS techniques for the slope instability studies. Data obtained from historical landslide occurrences were verified with new locations obtained from high resolution orthophotos and Google Earth application. Landslide areas were mapped using Arc Map and finally the Landslide Inventory for the Achaia’s Prefecture was created.
An application of GIS analysis on structural data from metamorphic rocks in Santorini Island.
Authors: Marsellos Α. Ε. , Foster D. A. , Min K. , Kidd W. S.F. , Garver J. , Kyriakopoulos K. 
Published: January 2017

The Santorini volcanic island is located in the northern Cretan Sea and is part of the ecent subduction-related volcanic arc. The opening of Cretan Sea is the result of extension associated with a series of ductile and brittle detachment faults developed since the Middle Miocene. A detachment between two exhumed metamorphic units is exposed at Athinios, on Santorini Island. Two exhumed metamorphic units are identified that show evidence of similar brittle deformation, but distinctive ductile and ductile-brittle structures. Different thermal histories indicate that a Miocene metamorphic unit is juxtaposed structurally below an Eocene metamorphic unit. In this paper, a prediction map of structural observations in Athinios is generated with statistical and GIS software, and shows a spatial distribution consistent with the exposure of two metamorphic units. K-Mean Cluster analysis using SPSS software on lineation azimuths of the metamorphic rock units shows two populations with center values of 347.2o ± 0.73o degrees (NNW to N) and 003.4o ± 0.83o degrees (N to NNE). NNW-lineation (arc-parallel extension) population belongs to the lower Miocene metamorphic unit and the NNE-lineation represents the Eocene metamorphic unit that was affected by arc-normal extension. A geostatistical map of ordinary Kriging type displays the possible exposed tectonic contacts. This methodology provides a structural prediction map that after field verification facilitates efficient structural and thermochronological sampling.
The role of genetic factors in predicting results of obesity treatment with sibutramine – serotonin-norepinephrine reuptake inhibitor
Authors: Galieva Marina , Troshina Ekaterina , Mazurina Nataliya , Artiushin Andrey , Pavlova Anastasia , Volynkina Anna , Aksyonova Marina , Logvinova Oksana 
Published: January 2017

Aim. To study the influence of SERT and GNB3 gene polymorphisms on the results of the treatment of obesity by serotonin-norepinephrine reuptake inhibitors.Methods. Patients who didn’t achieve significant weight loss in 3 month period during PrimaVera Study were selected for the genetic evaluation and compared with the group of “effective treatment”. The study included 66 patients (57 females and 9 males), mean age 39.29 ± 12.64 years, who received Reduxin (sibutramine + MCC) at the dose of 10 mg. Term follow-up was 3 months. Clinical examination and determination of biochemical parameters was performed at baseline and at the end of the observation period. In order to assess the type of eating behavior and identify hidden depressions a validated questionnaire was used (questionnaire "The types of eating disorders» (DEBQ), Beck Depression Scale). Also conducted a genetic study to assess SERT and GBN3 gene polymorphisms.Results. In the second group presence of S-allele SERT-gene was significantly associated with higher rates of external type of eating behavior. A statistically significant correlation between the genotype or allele of either body weight, rates of blood pressure, heart rate and cholesterol have not been found. In the first group there was a statistically significant association of S-allele carrier with less weight loss -2.8 kg (compared to l-allele) and higher rates at baseline glucose 5.38 ± 0.63 mmol / l (compared to L-allele of -3.28 kg and 5.04 ± 0.91 mmol / l).In the study of GBN3 polymorphism in the second group among CC genotype carriers there were higher levels of systolic blood pressure (SBP) before treatment (129.27 ± 9.16 mmHg), SBP and diastolic blood pressure after 3 months of treatment (127.36 ± 8.16 and 78.36 ± 4.3 mmHg) compared with CT genotype (117.27 ± 12.5; 115.45 ± 10.6; 72.91 ± 6.0 mm Hg, respectively) (p 0.05). Also among the carriers of C-allele there were more severe manifestations of depressive syndrome in comparison with T-allele carriers.Conclusion. Among the carriers of S-allele of SERT gene body weight loss during Reduxin treatment was lower than among the carriers of the L-allele; among the carriers of CC genotype of GBN3 gene higher blood pressure was higher at baseline and during Reduxin treatment, as well as more severe symptoms of a depressive syndrome.
Consideraciones para un Programa de Desarrollo Profesional que orienta al profesor a re-conceptualizar su enseñanza -Considerations for a Professional Development Program that instructs teachers to re-conceptualize their teaching
Authors: Ravanal-Moreno Eduardo 
Published: January 2017

Las demandas por una enseñanza de calidad ponen el acento indiscutiblemente en el rol del profesor, por lo tanto, se debe contribuir a su desarrollo a partir de programas que se focalicen en los requerimientos y necesidades profesionales que exige una enseñanza de calidad. En ese marco, un sistema de desarrollo profesional que enfatiza en la actualización y perfeccionamiento del profesor sobre la disciplina y las técnicas de enseñanza como lo plantea la política pública en Chile, quizás, no sea la solución plausible para promover una enseñanza de calidad por la racionalidad técnica que lo orienta. El artículo busca aportar a la discusión sobre el conocimiento didáctico del contenido como un eje para el desarrollo profesional del profesor de biología por su alta incidencia en la enseñanza. Se presta atención a los aspectos implicados en el desarrollo profesional y al conocimiento didáctico como un requerimiento profesional necesario para la enseñanza. Se proponen algunas consideraciones para el diseño de un programa de desarrollo profesional que oriente al profesorado a cambiar su epistemología personal para una nueva conceptualización de la práctica pedagógica, entre ellas: (i) Trabajar con el profesorado desde sus preocupaciones profesionales en una plano cognitivo, contextual y situado, (ii) Promover una actividad de reflexión que favorezca el transito entre los dominios: personal, fuentes, práctico y de consecuencia de enseñanza y, (iii) Discutir teóricamente los nuevos cuestionamientos para enfrentar las dificultades de la enseñanza y re-estructurar el conocimiento didáctico del contenido del profesor.
Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease
Authors: Ye Xuan , Feng Tuancheng , Tammineni Prasad , Chang Qing , Jeong Yu Young , Margolis David J. , Cai Huaibin , Kusnecov Alexander , Cai Qian 
Published: February 2017

Amyloid-β (Aβ) peptides play a key role in synaptic damage and memory deficits in the early pathogenesis of Alzheimer's disease (AD). Abnormal accumulation of Aβ at nerve terminals leads to synaptic pathology and ultimately to neurodegeneration. β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the major neuronal β-secretase for Aβ generation. However, the mechanisms regulating BACE1 distribution in axons and β cleavage of APP at synapses remain largely unknown. Here, we reveal that dynein–Snapin-mediated retrograde transport regulates BACE1 trafficking in axons and APP processing at presynaptic terminals. BACE1 is predominantly accumulated within late endosomes at the synapses of AD-related mutant human APP (hAPP) transgenic (Tg) mice and patient brains. Defective retrograde transport by genetic ablation ofsnapinin mice recapitulates late endocytic retention of BACE1 and increased APP processing at presynaptic sites. Conversely, overexpressing Snapin facilitates BACE1 trafficking and reduces synaptic BACE1 accumulation by enhancing the removal of BACE1 from distal AD axons and presynaptic terminals. Moreover, elevated Snapin expression via stereotactic hippocampal injections of adeno-associated virus particles in mutant hAPP Tg mouse brains decreases synaptic Aβ levels and ameliorates synapse loss, thus rescuing cognitive impairments associated with hAPP mice. Altogether, our study provides new mechanistic insights into the complex regulation of BACE1 trafficking and presynaptic localization through Snapin-mediated dynein-driven retrograde axonal transport, thereby suggesting a potential approach of modulating Aβ levels and attenuating synaptic deficits in AD.SIGNIFICANCE STATEMENTβ-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) trafficking and synaptic localization significantly influence its β secretase activity and amyloid-β (Aβ) production. In AD brains, BACE1 is accumulated within dystrophic neurites, which is thought to augment Aβ-induced synaptotoxicity by Aβ overproduction. However, it remains largely unknown whether axonal transport regulates synaptic APP processing. Here, we demonstrate that Snapin-mediated retrograde transport plays a critical role in removing BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Aβ production. Adeno-associated virus–mediated Snapin overexpression in the hippocampus of mutant hAPP mice significantly decreases synaptic Aβ levels, attenuates synapse loss, and thus rescues cognitive deficits. Our study uncovers a new pathway that controls synaptic APP processing by enhancing axonal BACE1 trafficking, thereby advancing our fundamental knowledge critical for ameliorating Aβ-linked synaptic pathology.
Organization of the Anterior Limb of the Internal Capsule in the Rat
Authors: Coizet Veronique , Heilbronner Sarah R. , Carcenac Carole , Mailly Philippe , Lehman Julia F. , Savasta Marc , David Oivier , Deniau Jean-Michel , Groenewegen Henk J. , Haber Suzanne N. 
Published: February 2017

Dysfunction of the orbitofrontal (OFC) and anterior cingulate (ACC) cortices has been linked with several psychiatric disorders, including obsessive-compulsive disorder, major depressive disorder, posttraumatic stress disorder, and addiction. These conditions are also associated with abnormalities in the anterior limb of the internal capsule, the white matter (WM) bundle carrying ascending and descending fibers from the OFC and ACC. Furthermore, deep-brain stimulation (DBS) for psychiatric disorders targets these fibers. Experiments in rats provide essential information on the mechanisms of normal and abnormal brain anatomy, including WM composition and perturbations. However, whereas descending prefrontal cortex (PFC) fibers in primates form a well defined and topographic anterior limb of the internal capsule, the specific locations and organization of these fibers in rats is unknown. We address this gap by analyzing descending fibers from injections of an anterograde tracer in the rat ACC and OFC. Our results show that the descending PFC fibers in the rat form WM fascicles embedded within the striatum. These bundles are arranged topographically and contain projections, not only to the striatum, but also to the thalamus and brainstem. They can therefore be viewed as the rat homolog of the primate anterior limb of the internal capsule. Furthermore, mapping these projections allows us to identify the fibers likely to be affected by experimental manipulations of the striatum and the anterior limb of the internal capsule. These results are therefore essential for translating abnormalities of human WM and effects of DBS to rodent models.SIGNIFICANCE STATEMENTPsychiatric diseases are linked to abnormalities in specific white matter (WM) pathways, and the efficacy of deep-brain stimulation relies upon activation of WM. Experiments in rodents are necessary for studying the mechanisms of brain function. However, the translation of results between primates and rodents is hindered by the fact that the organization of descending WM in rodents is poorly understood. This is especially relevant for the prefrontal cortex, abnormal connectivity of which is central to psychiatric disorders. We address this gap by studying the organization of descending rodent prefrontal pathways. These fibers course through a subcortical structure, the striatum, and share important organization principles with primate WM. These results allow us to model primate WM effectively in the rodent.