bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19 on pro- and antiatherogenic lipoproteins (cross-sectional population study)
Authors: Sadovnikov P. S. , Kyznetsova Yu. A. , Golchina P. S. , Gurevich V S. 
Published: October 2024

Aim. The aim of this cross-sectional retrospective study was to study the effect of SARS-CoV-2 S1/S2 infection on population lipid parameters, which are leading risk factors for the development and progression of atherosclerosis, which can be significantly distorted in systemic inflammation and, in particular, during respiratory viral infections.Material and methods. We analyzed anonymized results of one-time, one-year studies of complete lipid profiles and related laboratory parameters performed in the Helix Laboratory Service from February 1, 2015 to December 30, 2020 in 238541 males and 384437 females aged from 22 to 83 years in 334 populated areas of the European Russia using Roche Cobas C502, C702 (Roche Diagnostics GmbH, Mannheim, Germany), LIAISON XL (DiaSorin S.p.A, Italy) analyzers.Statistical analysis included methods of descriptive statistics, distribution analysis, sample comparisons, and search for dependencies.Results. A dramatic change in the magnitude and nature of seasonal population fluctuations in low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (HDL-C) during the COVID-19 spread has been identified.COVID-19 differentially affects the relationship between high-sensitivity C-reactive protein (hsCRP) and atherogenic and antiatherogenic lipoproteins. These relationships have sex differences, are nonlinear, and in relation to HDL-C are associated with the level of specific anti-SARS-CoV-2 S1/S2 antibodies.Up to a hsCRP level of 2,5 mg/l, there is a significant increase in population levels of low-density lipoprotein cholesterol with a correlation coefficient of 0,14 for women (p<0,001) and 0,10 for men (p<0,001). At hsCRP levels >2,5 mg/l, the trend reverses. At the same time, HDL-C levels sharply decrease with a negative correlation of -0,23 (p<0,001) in women and -0,22 (p<0,001) in men with hsCRP values <2,5 mg/l, followed by a less pronounced decline.Conclusion. The study results may be useful for optimal prevention development and adequate assessment of atherogenic dyslipidemia treatment effectiveness in patients after COVID-19.
Transluminal balloon angioplasty and stenting of coronary arteries after prior orthotopic heart transplantation: a case report
Authors: Bapinaev A. A. , Bapinaeva A. A. , Tkhabisimova I. K. , Kogotizhev A. R. 
Published: October 2024

Introduction. Today, heart failure (HF) is the most common natural outcome of diseases that are not diagnosed and treated in time. Despite the advances in cardiovascular pharmacotherapy, orthotopic heart transplantation is a generally recognized gold standard for the treatment of end-stage heart failure.Brief description. The article describes a 55-year-old male patient admitted to the Cardiology Dispensary (Kabardino-Balkarian Republic) with a clinical picture of non-ST segment elevation acute coronary syndrome (ACS). Earlier in 2017, the patient underwent orthotopic heart transplantation (OHT) for end-stage HF due to dilated cardiomyopathy. Hypertension was registered 2,5 years after surgery, and clinical manifestations of HF were registered for 5 years. In 2024, coronary angiography revealed subtotal stenosis of 95% in the middle segment of the anterior descending artery. Intraoperatively, the consensus assessed the risk and made a decision on surgical endovascular treatment of the stenosis. The postoperative period was uneventful.Discussion. The presented case is an example of timely diagnosis of coronary artery disease in a transplanted heart and successful transluminal balloon angioplasty and stenting of the anterior descending artery.
Hip replacement in a heart transplant patient: a case report
Authors: Tkhatl L. K. , Tatarintseva Z. G. , Kosmacheva E. D. , Barbukhatti K. O. 
Published: October 2024

Solid organ transplantation is considered the most effective treatment for endstage heart, lung, pancreatic, liver, and kidney diseases. The increasing number of transplants performed, and long-term survival of recipients have contributed to an increase in the diagnostic rate of non-transplant-related diseases.Heart transplant patients are at increased risk of complications when undergoing elective or emergency surgery. We report a case of hip replacement in a young man after orthotopic heart transplantation.
Association of novel biomarkers of systemic inflammation with atherosclerosis and its severity
Authors: Shvarts V. A. , Talibova S. M. , Sokolskaya M. A. , Ispiryan A. Yu. , Shvarts E. N. , Petrosyan A. D. , Merzlyakov V. Yu. , Skopin A. I. , Donakanyan S. A. 
Published: October 2024

Aim. To compare the levels of novel biomarkers of systemic inflammation in pati­ents with and without atherosclerosis, as well as between groups of patients with atherosclerosis of different severity.Material and methods. Patients with suspected coronary artery disease after selective coronary angiography were included. The analysis included 901 patients with mean age of 61±10 years (men, 60% (n=549)). The patients were divided into two following groups: with and without atherosclerosis. The Propensity Score Matching method was used to adjust for baseline clinical differences.Results. In the group with atherosclerosis, the values of the systemic inflam­mation response index (SIRI), systemic immune-inflammation index (SII) and ag­gregate index of systemic inflammation (AISI) were significantly higher than in patients without atherosclerosis: 0,906 (0,632; 1,36) vs 0,745 (0,519; 1,02), p<0,001; 457 (350; 641) vs 425 (313; 547), p=0,005 and 233 (148; 346) vs 179 (121; 263), p<0,001, respectively. ROC analysis showed the following threshold values of the studied parameters: for SIRI >1,05, area under the curve (AUC) confidence interval (CI) — 0,615 (0,571-0,658), p<0,001, sensitivity — 42,6%, specificity — 77,3%; for SII >368, AUC CI — 0,572 (0,528-0,616), p=0,004, sensitivity — 72,1%, specificity — 43,4%; for AISI >248, AUC CI — 0,604 (0,560-0,647), p<0,001, sensitivity 47,4%, specificity 71,1%. SIRI had the highest AUC. When comparing 6 groups according to the Coronary Artery Surgery Study (CASS) classification, significant differences were found in SIRI and AISI, p<0,001 and p=0,0016, respectively. However, these differences did not have a logical pattern.Conclusion. Novel markers of systemic inflammation (SIRI, SII and AISI) were significantly higher in patients with confirmed atherosclerosis than in patients without it. There are following threshold levels associated with atherosclerosis: for SIRI >1,05, for SII >368, for AISI >248.
Pharmacokinetics and bioequivalence of the generic and original dabigatran etexilate after a single dose in healthy volunteers
Authors: Vasilyuk V. B. , Faraponova M. V. , Verveda A. B. , Syraeva G. I. , Vikharev Yu. B. , Popov A. V. , Kovalenko A. L. 
Published: October 2024

Aim. To study the comparative pharmacokinetics and confirmation of bioequivalence of the generic (T) and original (R) dabigatran etexilate in healthy volunteers after a single oral dose under fasted conditions.Material and methods. To confirm bioequivalence, an open-label, randomized, replication, crossover, four-step study was conducted to compare the pharmacokinetics and bioequivalence of generic and original dabigatran with a single oral dose 150 mg dabigatran etexilate under fasted conditions in adult healthy male and female volunteers. Sixty-eight subjects participated in the study. During the study, blood plasma samples were taken from volunteers, in which the concentration of total and free dabigatran was determined. Based on the data obtained, pharmacokinetic and statistical analysis was carried out and 90% confidence intervals were calculated for the ratio of mean pharmacokinetic parameters (Сmax, Tmax, AUC0-t, AUC0-∞, AUCt-∞, T1/2, AUCt-∞/AUC0-∞) for total and free dabigatran.Results. The established 90% confidence intervals for the ratio of AUC0-t, AUC0-∞ and Cmax values for total dabigatran were 82,56-96,36% (mean ratio, 89,19%), 82,39-95,90% (mean ratio, 88,89%) and 85,98-99,17% (mean ratio, 92,34%), respectively. The established 90% confidence intervals for the ratio of AUC0-t, AUC0-∞ and Сmax values for free dabigatran were 83,37-98,29% (mean ratio, 90,53%), 82,98-97,33% (mean ratio, 89,87%) and 85,04-99,28% (mean ratio, 91,88%), respectively. For the estimated pharmacokinetic parameters of dabigatran etexilate, 90% confidence intervals ranged from 80-125% for AUC0-t, AUC0-∞ and Cmax. Additional safety analysis was carried out. Generic and original dabigatran were well tolerated by the volunteers. There were no significant differences in vital signs, paraclinical characteristics throughout the study compared with the initial data, as well as significant differences between the drugs in all studied parameters of adverse events.Conclusion. The study showed that generic and original dabigatran are bio­equivalent. In addition, the data obtained indicate that the agents have similar safety profiles.
Rice and its nutritional significance
Authors: Lalitha A  
Published: October 2024

Rice is a staple food for millions of populations in the world and originated from a wild grass to a crop. The Asian civilization was built on rice. The rice cultivation changed the lives of hunters into farmers. The domestication of rice in India dates back to the 7th millennium BC. Due to industrialization, the traditional practice of hand pounding was overtaken by rice processing mills, which led to the production of white polished rice, devoid of many nutrients. Studies confirmed that higher consumption of white rice increased the risk for diabetes and cardiovascular disease, high in India. In the current scenario, the disease prevalence is increasing, and customers are in search of nutritious foods with potential health benefits. This paper outlines the origin of rice and its nutritional value.
Correction to “Insulin-like growth factor-1 on cycle day 2 and assisted reproductive techniques outcome: A cross-sectional study” [Int J Reprod BioMed 2023; 21: 139-146]
Authors: Abbasi Fariba , Davar Robab , Shamsi Farimah , Dashti Saeideh 
Published: October 2024

The publisher has been informed of an error that occurred on pages 139-146 (Vol. 21; No. 2) which the ORCID ID of the corresponding author must be changed to “0000-0001-7089-0772”. The publisher wishes to apologize for this error. The online version of the article has been updated on 31 August 2024 and can be found at https://doi.org/10.18502/ijrm.v21i2.12804.
The possible regulatory role of miR-4463 and its target gene CYP19A1 on the ovarian response in the women with diminished ovarian reserve: A case-control study
Authors: Yazdanian Azam , Lotfi Marzieh , Montazeri Fateme , Dashti Saeideh , Sheikhha Mohammad Hasan 
Published: October 2024

Background: Diminished ovarian reserve (DOR) is a condition that affects fertility by reducing the reproductive potential of the ovary. The altered expression profile of cumulus cells (CCs) can negatively affect the quality and quantity of oocytes in the ovaries. Recent studies suggest that circulating miRNAs play a significant role in the ovary function, and their serum expression changes can be valuable biomarkers for predicting ovarian function.
Objective: Investigating the expression levels of circulating miRNA-4463 and its target cytochrome P450 19A1 gene (CYP19A1) in DOR-CCs in order to find a molecular pathway involved in DOR.
Materials and Methods: In this case-control study, a total of 20 DOR-women and 20 women with normal ovarian reservation aged between 20–34 yr referred to Yazd Reproductive Science Institute, Yazd, Iran were included in the study. Serum and CCs were collected, and real time-polymerase chain reaction was performed to investigate the expression level of miR-4463, and its target gene CYP19A1.
Results: Our results showed an inverse relationship between miR-4463 and CYP19A1 expression levels. Therefore, the increase in the expression of miR-4463 was significantly evident in DOR-women compared to the control group (p = 0.0019), while the expression of its target gene, CYP19A1, has significantly decreased in these women (p = 0.001).
Conclusion: The present study suggests that miR-4463 and CYP19A1 pathways could regulate ovary function. Therefore, examination of this miRNA could be a promising parameter for predicting ovarian reserve and their response to stimulation protocols.
Key words: Ovarian response, CYP19A, miR-4463, Diminished ovarian reserve (DOR), Cumulus cells (CCs).
The Influence of Job Training, Motivation, and Work Environment on Employee Performance at PT. Telekomunikasi Indonesia, Tbk Kediri City
Authors: Asiska Yuke Sepvi Dinata , Kristanti Desi , Yunanto Yogi , Bagaskara Whicka Galuh 
Published: October 2024

This investigation intends to determine and anatomize the effect of job training, motivation, and work environment on employee performance at PT Telekomunikasi Indonesia, Tbk Kediri City. A key element in a company's success is employee performance. Job training, motivation, and a positive work environment are necessary for effective employee performance. Data gathering techniques include distributing questionnaires and performing direct talks with 50 permanent employees of PT. Telekomunikasi Indonesia, Tbk Kediri City. Analyzing data found that job training, motivation, and work environment affect employee performance at PT. Telekomunikasi Indonesia, Tbk Kediri City. This study has a noteworthy impact on job training, motivation, and work environment on employee performance. This research contributes science to human resources. The results can be applied to PT. Telekomunikasi Indonesia, Tbk Kediri City, to optimize job training, motivate employees, and improve a good work environment, so that it can affect employee performance and achieve company success. In further research, it’s hoped that they will research broader and different research objects. Thus, the results attained will benefit numerous parties.
Integration of Local Potential in Science Learning to Improve 21st-Century Skills
Authors: Afkarina Izzata Dini Naffa , Febri Setiya Rini Endah 
Published: October 2024

Science learning that integrates local culture and wisdom is an important approach that is to continue to be developed in the current educational context. Along with the growing need for qualified and competitive human resources, adjustments in learning are crucial to prepare students with 21st-century skills. This research aims to evaluate how integrating local potential in science learning to improve 21st-century skills. The method used in this study is a Systematic Literature Review (SLR), with an analysis of 13 articles selected based on relevant research criteria and focus. The study results show that using learning media based on local potentials such as cultural traditions and natural resources has an important role in improving 21st-century skills, especially critical thinking and problem-solving skills. These findings underscore the importance of integrating local potential in science curricula to facilitate the development of essential skills in the modern era.
Allocyclic and autocyclic controls on facies distribution in interdistributary bayfill deposits of the Campanian Neslen Formation, Eastern Book Cliffs, Utah, U.S.A.
Authors: Kjærefjord Jostein Myking , Bullimore Scott 
Published: October 2024

ABSTRACT
The Campanian Neslen Formation, in the eastern part of the Book Cliffs, is divided into three stratigraphic intervals. The middle Neslen interval consists of paralic bayfill deposits that average 23 m in thickness. This article describes the lateral and vertical variability within the bayfills deposited in this middle Neslen interval. Comprehensive mapping along 27 km of outcrops, including high-resolution description of 62 sedimentary logs and incorporation of wireline log data from 86 wells, has led to a detailed understanding of the processes related to infilling of interdistributary bays. Six vertically stacked heterolithic to sand-prone bayfill units are identified. A distinction is made between bayfill units and bayfill successions, based on their bounding autocyclic or allocyclic flooding surfaces. Units are bounded by high-frequency flooding surfaces, and show large lateral variations in thickness, facies associations, and lithology. These bayfill units are laterally subdivided into a varying number of bayfill successions, separated by interdistributary channel systems or associated bayhead-delta facies associations. Lateral variation in facies architecture, salinity, and depositional energy levels are mapped in each bayfill succession. This variation is attributed to several controlling factors, including proximity to sediment entry points, water depth, the sequence stratigraphic position of the bayfill succession, and the compaction of underlying sandbodies. The detailed facies patterns and multitude of tributary causes described and discussed here are applicable to an overall understanding of facies architecture in paralic environments.
Pendugaan Viabilitas benih padi (Oryza sativa L.) dengan Uji Tetrazolium
Authors: Tri Utami Wati , Farmia Asih , Suharno Suharno 
Published: October 2024

Supporting factors for the success of rice planting include seed availability in sufficient quantities, high quality, and availability when needed. Conventional rice seed viability testing generally takes quite a long time, around 14 days. Therefore, it is necessary to develop several methods for quickly testing seed viability. This research aims to determine the coloring pattern of rice seeds, differences in viability tested with 0.25% tetrazolium concentration, and the relationship between the viability values of seeds tested for sprouting and those tested with 0.25% tetrazolium. This research was carried out from March to May 2023 at the Laboratory of the Central Java Seed Supervision and Certification Center. The treatments used were tests using the direct sprout test (rolled paper in plastic test) and the 0.25% concentration tetrazolium test method. The seeds used were seeds with different storage times (0, 1, 2, and 3 months) to obtain variations in seed vigor. The data obtained were analyzed using visual and descriptive analysis, t-test, and correlation analysis. The results showed that the tetrazolium test with a concentration of 0.25% on Inpari 42 rice seeds produced seven coloring patterns grouped into four viable seed and three non-viable seed coloring patterns. The 0.25% concentration tetrazolium test showed that the results had no significant effect and were closely related the results of the direct germination test so the rapid test could be used as a substitute for the (conventional) germination test on a wide scale.
Determinants of market outlet choice of the smallholder potato producers in south west shoa zone of Ethiopia
Authors: Gebeyehu Lemane , Fikadu Lelisa , Tolera Tadesse 
Published: October 2024

Abstract

This study was aimed at analyzing potato market outlet choice in woliso and wonchi districts of the south west shoa zone of Ethiopia. In this study, primary and secondary data sources were employed. The data were obtained from a sample of 368 farm households. Both descriptive and econometric methods have been employed for data analysis. The results of descriptive statistics show that the probabilities for potato producers to choose wholesalers, retailers, collectors, and consumers as market outlets were 51.63%, 52.72%, 45.92%, and 42.39%, respectively. Moreover, the results from the multivariate probit model indicate that the probability of choosing wholesalers, retailers, collectors, and consumers market outlet choice is significantly affected by age, sex, land allocated for potatoes, product supplied to market, distance to market, total livestock holding, and access to credit services. Based on the study's findings, we suggest the government and interested parties focus on enhancing rural-urban infrastructure and establishing the closest potato market in order to increase market accessibility.
Methylation Mesa define functional regulatory elements for targeted gene activation
Authors: Tenen Daniel , Bassal Mahmoud , Liu Yanjing , Suryatenggara Jeremiah , Wong Hannan , Jayasinghe Migara , Tang Jing Ping , Tan Hong Kee , Kwon Junsu , Zhou Qiling , Ummarino Simone , Ebralidze Alexander , Le Minh , Doench John , Chai Li , Benoukraf Touati , Hiwase Devendra , Thomas Daniel , Ruscio Annalisa Di 
Published: October 2024

Abstract

DNA methylation and mRNA expression correlations are often presented with inconsistent evidence supporting causal regulation. We hypothesized that causal regulatory methylation elements would exhibit heightened demethylation sensitivity. To investigate, we analyzed 20 whole genomic bisulfite sequenced samples before and after demethylation and identified narrow width (45 294 bp) elements within a short plateau, termed Methylation Mesa (MM). The Mesa signature was conserved across species and was independent of CpG islands. Mesa also demonstrate high concordance with primed and active histone marks. To assess causality, we developed CRISPR DiR, a highly precise targeted demethylation technology. Targeted demethylation of a Mesa triggers locus and distal chromatin rewiring events that initiate mRNA expression significantly greater than promoter CpG island targeting. Thus, Mesa are self-sustaining epigenetic regulatory elements that maintain long-term gene activation through focused demethylation only within the Mesa core, resulting in subsequent histone modifications and chromatin rewiring events that interact with distal elements also marked as Mesas.