bluuebunny/crossref_metadata_2025_split huggingface dataset:
Latent Profiles of Fear of Cancer Recurrence in Breast Cancer Patients of Reproductive Age and Associations With Reproductive Concerns
Authors: Liu Cuiting , Chen Liangying , Zheng Jiansheng , Yu Xuefen , Gao Huiting , Qiu Lijuan , Liu Cuiping 
Published: September 2024

ABSTRACTAimTo identify distinct profiles of fear of cancer recurrence (FCR) among breast cancer patients of reproductive age, investigate the relationship between these profiles and reproductive concerns and explore potential risk factors encompassing sociodemographic, clinical and reproductive characteristics.DesignA cross‐sectional study was conducted from January 2022 to September 2022.MethodsA convenience sample of 210 reproductive‐aged breast cancer patients completed a questionnaire that included a general information section, the Fear of Progression Questionnaire‐Short Form (FoP‐Q‐SF) and the Reproductive Concerns After Cancer Scale (RCAC). Latent profile analysis was conducted using the scores of the 12 items from the FoP‐Q‐SF as explicit variables, while univariate and multiple logistic regression analyses were employed for statistical analysis.ResultsThree latent variables were identified: low FCR‐stable group (27.6%), moderate FCR‐uneasy group (17.2%) and high FCR‐intense group (55.2%). This study found that FCR was predicted by age, education level, cancer stage, chemotherapy and fertility intention. Furthermore, patients with heightened reproductive concerns exhibited a higher likelihood of belonging to the high FCR‐intense group.ConclusionThese findings indicate that FCR varies among breast cancer patients of reproductive age and demonstrates individual differences.ImplicationEarly identification of FCR patterns in patients is crucial for medical professionals, with particular attention given to those in the high‐intensity FCR group. Tailored prevention and care strategies should be implemented based on the unique characteristics and influencing factors associated with different potential categories of FCR among patients of childbearing age with breast cancer.Patient or Public ContributionNo patient or public contribution.
Dual Caregiving and Mental Health Among Long‐Term Care Nursing Assistants: The Moderating Role of Social Support
Authors: Liu Yen‐Ling , Pien Li‐Chung , Liu Guang‐Hsing , Chen Tsung‐Po , Lin Yun‐Ping , Lin Cheng‐Li , Cheng Wan‐Ju 
Published: September 2024

ABSTRACTAimTo investigate the association of long‐term care nursing assistants' dual caregiving roles with mental health and to determine whether social support moderates this relationship.DesignA cross‐sectional survey.MethodsWe surveyed 962 certified long‐term care nursing assistants working in long‐term care and medical facilities across Taiwan from October 2022 to July 2023. ‘Dual caregiving roles’ denote the fulfilment of caregiving duties both at work and within families. Mental health was evaluated using the 5‐item Brief Symptom Rating Scale. Logistic regression analysis was utilized to investigate the association of dual caregiving roles and psychological job demands with poor mental health. Moreover, we explored whether family, colleague, and supervisor support moderated the association between dual caregiving roles and poor mental health.ResultsAmong long‐term care nursing assistants, 15% had dual caregiving responsibilities. Individuals with both dual caregiving roles and high psychological job demands faced the highest risk of poor mental health compared to those without dual caregiving roles and low psychological job demands. Having dual caregiving roles was associated with poor mental health compared to workers without such roles. Additionally, support from family, colleagues, and supervisors mitigates the association between caregivers' dual caregiving roles and poor mental health.ConclusionA substantial proportion of long‐term care nursing assistants had dual caregiving roles, leading to an additional mental health burden when combined with high psychological job demands. High social support attenuated this association.Implications for the ProfessionLong‐term care nursing assistants with dual caregiving roles had poorer mental health outcomes. Yet, support from family, colleagues, and supervisors mitigated these effects. These results emphasize the importance of enhancing social support to protect the mental well‐being of long‐term care nursing assistants managing both formal and informal caregiving duties.Reporting MethodThis study adheres to the STROBE guideline of reporting.Patient or Public ContributionNo Patient or Public Contribution.
A Cross‐Sectional Study Exploring the Impact of Violence on Healthcare Employees' Work Engagement and Meaningful Work
Authors: Tiryaki Sen Hanife , Sahin Safiye , Polat Nimet 
Published: September 2024

ABSTRACTAimThis study aims to determine the prevalence of workplace violence against healthcare professionals and its effects on work engagement and meaningful work in healthcare settings.DesignThis study is designed as an analytical cross‐sectional study.MethodsThis study surveyed 676 healthcare professionals in Turkiye between June and December 2022, using face‐to‐face and online methods. Scales measured exposure to and witnessing violence, work engagement, and meaningful work. The study has adhered to STROBE guidelines. Statistical analyses included descriptive, correlation, and linear regression.ResultsAccording to the results, shouting and cursing by patients and their companions were determined as the most common type of violence encountered by healthcare professionals. The effect of healthcare professionals' exposure to violence from patients' companion on work engagement and witnessing to violence from colleagues on meaningful work were found to be negative and significant.DiscussionThe findings emphasise the urgent need for interventions addressing workplace violence against healthcare professionals. Since workplace violence significantly reduces work engagement and the sense of meaningful work in healthcare setting.ImpactBy highlighting the prevalence of workplace violence and its negative impact on both work engagement and meaningful work in healthcare setting, this study provides critical evidence for policymakers and healthcare administrators.Patient or Public ContributionThe participants in this study were healthcare professionals who had direct contact with patients and their relatives.
Bridging the Gap Rather Than Filling the Entire Valley—Anatomic Insights When Treating the Medial Infraorbital Region
Authors: Bernardini Francesco P. , Skippen Brent , Cetto Raul , Calomeni Mariana , Cotofana Sebastian , Urso Simone Ugo , Paternostro Ferdinando , Hartstein Morris E. 
Published: September 2024

ABSTRACTBackgroundThe treatment of the medial infraorbital region also termed the tear trough has become increasingly popular by the use of soft tissue fillers in a minimally invasive approach using a cannula.MethodsA total of 246 tear troughs were injected and investigated originating from 123 study participants. The clinical outcome was evaluated 6 months after the treatment by independent observers based on standardized frontal images and the procedure was documented by ultrasound imaging.ResultsOn average, 0.26 (0.1) cc [range: 0.08–0.32] of soft tissue filler material was injected per tear trough. Tear trough depth was before the treatment rated as 2.12 (0.4), whereas after the treatment it was 1.15 (0.4) (p < 0.001). Hyperpigmentation score was 2.19 (0.4) before the treatment, whereas after the treatment it was 1.31 (0.5) (p < 0.001). Intraorbital fat pseudo‐prolapse severity was rated before the treatment 1.88 (0.7), whereas it was rated after the treatment 1.14 (0.3) (p < 0.001). Wrinkle severity of the lower eyelid was rated before the treatment 1.51 (0.6), whereas it was rated after the treatment 1.12 (0.3) (p < 0.001).ConclusionThe results of this retrospectively investigated case series revealed that the conducted injection technique for treating the tear trough for medial infraorbital hollowing with a cannula provided statistically significant clinical improvement with a limited adverse events profile. The technique utilized an injection approach which was perpendicularly oriented to the longitudinal axis of the tear trough thereby “bridging the gap instead of filling the entire valley.”
Temperature fluctuations, climate uncertainty, and financing hindrance
Authors: Wu Qingyang , Shahbaz Muhammad , Kyriakou Ioannis 
Published: September 2024

AbstractUndesirable temperature fluctuations pose significant financial risks for enterprises. By merging fine‐grained meteorological data with a panel of publicly listed firms, we delve into the relationship between temperature volatility and financing constraints. Our analysis reveals a positive correlation between temperature fluctuations and increasingly stringent financing limitations. State‐owned or large‐scale enterprises endowed with greater resources and risk diversification mechanisms are more likely to counteract the adverse effects of temperature volatility. Furthermore, we furnish evidence indicating that temperature fluctuations exert a substantial influence on corporate labor productivity. In response, companies tend to expand their workforce and elevate wages during the fiscal year. Faced with dwindling income and escalating operational costs, enterprises significantly amplify their insurance expenditures. The pronounced escalation in default risk and borrowing costs could undermine investors' sanguine profit expectations, subsequently prompting declines in firms' price‐to‐earnings and price‐to‐book ratios. Our study underscores the imperative for executive management teams to prudently account for climate change‐induced financing constraints when devising investment and production strategies.
‘I Think the First Priority is Physically Safe First, Before You Can Actually Get Psychologically Safe’: Staff Perspectives on Psychological Safety in Inpatient Mental Health Settings
Authors: Vogt Katharina Sophie , Baker John , Morys‐Edge Matthew , Kendal Sarah , Mizen Emily , Johnson Judith 
Published: September 2024

ABSTRACTIntroductionWhile the concept of psychological safety has been gaining momentum, research concerning psychological safety in inpatient mental health wards is lacking.AimTo investigate how psychological safety is conceptualised by healthcare staff in inpatient mental health units, and what barriers and facilitators exist.MethodReflexive Thematic Analysis was used to analyse 12 interviews.ResultsParticipants conceptualised psychological safety as feeling safe from physical harm, being able to develop meaningful relationships and feeling valued at work. Participants often did not feel physically safe at work, which led them to feel psychologically unsafe. Barriers to psychological safety were reliance on agency workers, punitive management approaches and the inherent risk in working with mental health inpatients. Facilitators included appropriate staffing ratios and skill mix, being able to form meaningful relationships and having access to support.DiscussionThe emphasis on the physical safety element within psychological safety means that existing definitions of psychological safety require extension for the mental healthcare context. However, large‐scale research is needed to further understand experiences of psychological safety in this group.Implications for PracticeA better understanding of the dimensions of psychological safety in inpatient mental health settings could support the development of tools to investigate psychological safety interventions. Organisations could support psychological safety through regular staff supervision and improved staffing ratios and skill mix.
Integrating PNPLA3 into clinical risk prediction
Authors: Chen Vincent L. , Vespasiani‐Gentilucci Umberto 
Published: September 2024

AbstractThe PNPLA3‐rs738409‐G variant was the first common variant associated with hepatic fat accumulation and progression of metabolic dysfunction‐associated steatotic liver disease (MASLD). Nevertheless, to date, the clinical translation of this discovery has been minimal because it has not yet been clearly demonstrated where the genetic information may play an independent and additional role in clinical risk prediction. In this mini‐review, we will discuss the most relevant evidence regarding the potential integration of the PNPLA3 variant into scores and algorithms for liver disease diagnostics and risk stratification, specifically focusing on MASLD but also extending to liver diseases of other etiologies. The PNPLA3 variant adds little in diagnosing the current state of the disease, whether in terms of presence/absence of metabolic dysfunction‐associated steatohepatitis or the stage of fibrosis. While it can play an important role in prediction, allowing for the early definition of risk profiles that enable tailored monitoring and interventions over time, this is most valuable when applied to populations with relatively high pre‐test probability of having significant fibrosis based on either non‐invasive tests (e.g. Fibrosis‐4) or demographics (e.g. diabetes). Indeed, in this context, integrating FIB4 with the PNPLA3 genotype can refine risk stratification, though there is still no evidence that genetic information adds to liver stiffness determined by elastography. Similarly, in patients with known liver cirrhosis, knowing the PNPLA3 genotype can play a role in predicting the risk of hepatocellular carcinoma, while more doubts remain about the risk of decompensation.
Investigating feelings of imposterism in first‐year medical student narratives
Authors: Kruskie Megan E. , Frankel Richard M. , Isaacson J. Harry , Mehta Neil , Byram Jessica N. 
Published: September 2024

AbstractIntroductionImposter phenomenon (IP), feeling as if a person does not belong, has been reported in medical students at various rates. In medical literature, this phenomenon has often been defined as a ‘syndrome’, but other studies have described it as a dynamic experience that can have various impacts on different people at different time points. Although studies have linked IP with other phenomena such as burnout in residents and physicians, no studies have examined its aetiology nor how these feelings are experienced by medical students.MethodsWith the use of social identity theory as a framework, the authors analysed 233 reflective essays for elements of IP across eight cohorts of medical students from two institutions. Students responded to a prompt that asked: ‘What was one part of your identity that you thought you would have to change in order to become a physician?’ Included reflections were analysed using the framework method.ResultsElements of IP were identified in 121 reflections (52%) and were categorised into three major themes: (1) Comparing oneself to an idealised image of a medical student, (2) Comparing oneself to an idealised image of a physician and (3) Concerns about presentation of self to others. Each theme contained two or more sub‐themes. Commonly, students discussed how their own personality traits, experiences, backgrounds and identities cast doubt on their sense of belonging in medicine.DiscussionThe results of this study were consistent across both institutions, suggesting that imposter feelings are common among all first‐year medical students. However, the extent of the impact of these feelings on their identity formation depends on the individual lived experiences of students and the context in which these feelings arise. Encouraging reflective journaling and sharing of stories from all stages of education can normalise imposter feelings during the development of the professional identity as a physician.
Proactive Personality and Caring Behavior of Clinical Nurses: A Moderated Mediation Model of Emotional Intelligence and Disgust Sensitivity
Authors: Song Jiangyan , Huang Qionglei , Xie Lunfang , Ismail Tengku Alina Tengku , Sulaiman Zaharah 
Published: September 2024

ABSTRACTThe aims of the research were to investigate the mediating effect of emotional intelligence and the moderating effect of disgust sensitivity on the relationship between proactive personality and caring behavior among clinical nurses. A cross‐sectional design while adhering to STROBE guidelines was used for this study. Three hundred ninety‐three purposely selected nurses from three tertiary general hospitals completed an online survey. Measures included proactive personality, emotional intelligence, disgust sensitivity, and caring behavior. The findings showed that proactive personality positively predicted nurses' caring behavior, and that emotional intelligence played a mediating role in the relationship between proactive personality and caring behavior. Disgust sensitivity indirectly and negatively moderated the impact of proactive personality on nurses' caring behavior mainly in the second half of this moderated relationship. The findings underscore that the nursing managers may consider incorporating emotional intelligence topic in practical nursing skills training and improving nurses' ability to control their disgust sensitivity can improve their professional behavior, thus to provide patients with high‐quality nursing services.
Current challenges for plant biology research in the Global South
Authors: Auge Gabriela , Sunil Rohan Shawn , Ingle Robert A. , Rahul Puthan Valappil , Mutwil Marek , Estevez José M. 
Published: September 2024

SummaryIn an attempt to address the large inequities faced by the plant biology communities from the Global South (i.e. countries located around the tropics and the Southern Hemisphere) at international conferences, this Viewpoint is the reflexive thinking arising from the concurrent session titled ‘Arabidopsis and its translational research in the Global South’ organized at the International Conference of Arabidopsis Research 2023 (ICAR 2023) in Chiba, Japan in June 2023. Here, we highlight the main obstacles plant biology communities in the Global South face in terms of knowledge production, as measured by the unequal production and citation of publications, investigating and advancing local plant genomics and biodiversity, combating disparities in gender and diversity, and current initiatives to break isolation of scientists.
Analysis of randomly mutated AlSRKb genes reveals that most loss‐of‐function mutations cause defects in plasma membrane localization
Authors: Yamamoto Masaya , Ohtake Shotaro , Shinozawa Akihisa , Shirota Matsuyuki , Mitsui Yuki , Kitashiba Hiroyasu 
Published: September 2024

Summary

Only very limited information is available on why some nonsynonymous variants severely alter gene function while others have no effect. To identify the characteristic features of mutations that strongly influence gene function, this study focused on SRK which encodes a highly polymorphic receptor kinase expressed in stigma papillary cells that underlies a female determinant of self‐incompatibility in Brassicaceae.

A set of 300 Arabidopsis thaliana transformants expressing mutated SRKb from A. lyrata was constructed using error‐prone PCR and the genotype and self‐incompatibility phenotype of each transformant were determined.

Almost all the transformants showing the self‐incompatibility defect contained mutations in AlSRKb that altered localization to the plasma membrane. The observed mutations occurred in amino acid residues that were highly conserved across S haplotypes and whose predicted locations were in the interior of the protein.

Our findings suggested that mutations causing the self‐incompatibility defect were more likely to result from changes to AlSRKb biosynthesis than from loss of AlSRKb function. In addition, we examined whether the RandomForest and Extreme Gradient Boosting methods could predict the self‐incompatibility phenotypes of SRK mutants.
Hydrogen sulfide antagonizes cytokinin to change root system architecture through persulfidation of CKX2 in Arabidopsis
Authors: Wang Xiuyu , Liu Cuixia , Li Tian , Zhou Fangyu , Sun Haotian , Li Fali , Ma Ying , Jia Honglei , Zhang Xiaoyue , Shi Wei , Gong Chunmei , Li Jisheng 
Published: September 2024

Summary

Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule, which has been shown to play an important role in plant growth and development by coupling with various phytohormones. However, the relationship between H2S and cytokinin (CTK) and the mechanisms by which H2S and CTK affect root growth remain poorly understood.

Endogenous CTK was analyzed by UHPLC‐ESI‐MS/MS. Persulfidation of cytokinin oxidase/dehydrogenases (CKXs) was analyzed by mass spectrometry (MS). ckx2/CKX2wild‐type (WT), OE CKX2 and ckx2/CKX2Cys(C)62alanine(A) transgenic lines were isolated with the ckx2 background.

H2S is linked to CTK content by CKX2, which regulates root system architecture (RSA). Persulfidation at cysteine (Cys)62 residue of CKX2 enhances CKX2 activity, resulting in reduced CTK content. We utilized 35S‐LCD/oasa1 transgenic lines to investigate the effect of endogenous H2S on RSA, indicating that H2S reduces the gravitropic set‐point angle (GSA), shortens root hairs, and increases the number of lateral roots (LRs). The persulfidation of CKX2Cys62 changes the elongation of cells on the upper and lower flanks of LR elongation zone, confirming that Cys62 of CKX2 is the specificity target of H2S to regulate RSA in vivo.

In conclusion, this study demonstrated that H2S negatively regulates CTK content and affects RSA by persulfidation of CKX2Cys62 in Arabidopsis thaliana.
Natural variations in the Cis‐elements of GhRPRS1 contributing to petal colour diversity in cotton
Authors: Hu Wei , Chen Yanli , Xu Zhenzhen , Liu Linqiang , Yan Da , Liu Miaoyang , Yan Qingdi , Zhang Yihao , Yang Lan , Gao Chenxu , Liu Renju , Qin Wenqiang , Miao Pengfei , Ma Meng , Wang Peng , Gao Baibai , Li Fuguang , Yang Zhaoen 
Published: September 2024

SummaryThe cotton genus comprises both diploid and allotetraploid species, and the diversity in petal colour within this genus offers valuable targets for studying orthologous gene function differentiation and evolution. However, the genetic basis for this diversity in petal colour remains largely unknown. The red petal colour primarily comes from C, G, K, and D genome species, and it is likely that the common ancestor of cotton had red petals. Here, by employing a clone mapping strategy, we mapped the red petal trait to a specific region on chromosome A07 in upland cotton. Genomic comparisons and phylogenetic analyses revealed that the red petal phenotype introgressed from G. bickii. Transcriptome analysis indicated that GhRPRS1, which encodes a glutathione S‐transferase, was the causative gene for the red petal colour. Knocking out GhRPRS1 resulted in white petals and the absence of red spots, while overexpression of both genotypes of GhRPRS1 led to red petals. Further analysis suggested that GhRPRS1 played a role in transporting pelargonidin‐3‐O‐glucoside and cyanidin‐3‐O‐glucoside. Promoter activity analysis indicated that variations in the promoter, but not in the gene body of GhRPRS1, have led to different petal colours within the genus. Our findings provide new insights into orthologous gene evolution as well as new strategies for modifying promoters in cotton breeding.