bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation Methods and Influencing Factors on Accuracy for Static Virtual Articulation Obtained by Intraoral Scanners: A Critical Review of the Literature
Authors: Zheng Yuying , Zhang Tingmin , Liu Yuchen , Pradíes Guillermo , Wang Xin , Ma Dan , Bai Shizhu 
Published: September 2024

ABSTRACTObjectiveDigital technology in dentistry has advanced rapidly in recent years, and as a result, the identification of static virtual articulation as a crucial stage in the digital process has attracted increasing attention. The use of intraoral scanners (IOSs) has made the acquisition of occlusal records more efficient. The purpose of this article is to review information on evaluation methods and influencing factors on the accuracy of static virtual articulation obtained by intraoral scanners.OverviewAn electronic search of the published literature was performed up to November 2023 using five databases: PubMed, Cochrane, Embase, Web of Science, and Scopus. The inclusion criteria were defined as relevant clinical or in vitro English studies on the accuracy of the occlusal relationship obtained using intraoral scanners. Therefore, a total of 30 articles were selected, reviewed, and discussed. Based on the results of the literature review, three methods have been used to evaluate the accuracy of virtual interocclusal records, including distance measurement (10 studies), occlusal contact analysis (13 studies), and deviation analysis after superimposing casts (8 studies). However, direct comparisons between these studies are challenging due to the different methods employed. Factors that were found to potentially impact accuracies, such as the range of vestibular scans, the number and position of virtual interocclusal records (VIRs), the location and extension of edentulous areas, alignment methods, and evaluation software programs have been extensively studied, but the extent to which these factors affect accuracy remains uncertain and varies depending on the specific circumstances.ConclusionsA combination of multiple evaluation methods for a more rigid assessment of virtual interocclusal records may be a better approach. Attention should be given to the factors that may influence the accuracy of virtual interocclusal records. Future research should focus on optimizing these factors to improve the clinical applicability of virtual interocclusal records.Clinical SignificanceIn restorative dentistry, virtual interocclusal records obtained with intraoral scanners have been successfully used with acceptable accuracy, although they present some issues. Understanding the evaluation methods for virtual interocclusal records and the factors that may affect the accuracy of VIRs may lead to better use in clinical practice.
Assessment of urbanization‐related groundwater flooding process via Visual MODFLOW modeling: A case study for the northern part of Almaty city, Kazakhstan
Authors: Mirlas Vladimir , Zhakyp Altynay , Auelkhan Yergali , Anker Yaakov 
Published: September 2024

AbstractGroundwater flooding might be triggered by disregarding hydrogeological processes during urban area development. Such flooding might result in public disruption, engineering infrastructure destruction, and general damage to natural and human environments, as in the northern part of Almaty city. A MODFLOW groundwater flow model was used to simulate and quantitatively assess the changes in hydrogeological conditions affecting the groundwater flooding process. A field study of the Akbulak micro‐district research site showed that groundwater flooding occurred in its center owing to a water table hillock with a total area of 0.07 km2 and groundwater levels ranging from 1.2 to 0.25 m below the ground surface. The MODFLOW simulation suggested that this water table hillock developed from runoff, which, owing to a decrease in natural infiltration across an urbanized area, accumulated in low‐elevation areas and infiltrated. This runoff accumulation effect may be up to eight times the annual average precipitation amount. Once in local sub‐basins, larger runoff volume infiltrates into an underlying aquifer water table that is already high, might cause groundwater flooding in populated areas. The Almaty scenario simulation confirmed the field observations, suggesting that the clogging of the Karasu‐type stream has concentrated runoff to low‐elevation areas and is the leading cause of flooding.
Efficacy of a whole slide image‐based prediction model for lymph node metastasis in T1 colorectal cancer: A systematic review
Authors: Ichimasa Katsuro , Kouyama Yuta , Kudo Shin‐ei , Takashina Yuki , Nemoto Tetsuo , Watanabe Jun , Takamatsu Manabu , Maeda Yasuharu , Yeoh Khay Guan , Miyachi Hideyuki , Misawa Masashi 
Published: September 2024

AbstractBackground and AimAccurate stratification of the risk of lymph node metastasis (LNM) following endoscopic resection of submucosal invasive (T1) colorectal cancer (CRC) is imperative for determining the necessity for additional surgery. In this systematic review, we evaluated the efficacy of prediction of LNM by artificial intelligence (AI) models utilizing whole slide image (WSI) in patients with T1 CRC.MethodsIn accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines, a systematic review was conducted through searches in PubMed (MEDLINE), Embase, and the Cochrane Library for relevant studies published up to December 2023. The inclusion criteria were studies assessing the accuracy of hematoxylin and eosin‐stained WSI‐based AI models for predicting LNM in patients with T1 CRC.ResultsFour studies met the criteria for inclusion in this systematic review. The area under the receiver operating characteristic curve for these AI models ranged from 0.57 to 0.76. In the three studies in which AI performance was compared directly with current treatment guidelines, AI consistently exhibited a higher area under the receiver operating characteristic curve. At a fixed sensitivity of 100%, specificities ranged from 18.4% to 45.0%.ConclusionsArtificial intelligence models based on WSI can potentially address the issue of diagnostic variability between pathologists and exceed the predictive accuracy of current guidelines. However, these findings require confirmation by larger studies that incorporate external validation.
Developing a comprehensive account of embodied emissions within the Canadian construction sector
Authors: Wambersie Leopold , Ouellet‐Plamondon Claudiane 
Published: September 2024

AbstractConstruction activities are a major driver of greenhouse gas emissions worldwide. However, the majority of construction‐driven emissions are indirect, meaning that these emissions occur during the manufacturing and transport of construction materials. This is in contrast with direct emissions, which are directly emitted from construction machinery. These indirect impacts are represented as embodied emissions and are difficult to quantify at scale, limiting the effectiveness of climate policymaking in the building sector. This paper presents results from a comprehensive account of embodied emissions within the Canadian construction sector, at a resolution far higher than existing global accounts, as well as novel analyses of flows and intensities of embodied emissions. It has the specific goal of serving as a baseline for future analyses of decarbonization scenarios and the more general goal of highlighting the importance of a consumption‐based approach to climate policymaking in the sector. The accounts are produced via an environmentally extended input–output analysis based on Canadian supply–use tables for the year 2018, and results are presented for the 13 provinces and territories as well as 19 categories of buildings and infrastructure. Results show that demand from construction drives 13% of Canada's consumption‐based emissions, residential construction is by far the largest driver of emissions, and at 0.28 kgCO2eq per Canadian dollar of GDP, the efficiency of Canadian construction is roughly in line with the OECD average. A disproportionate share of emissions is driven by construction in provinces that are growing fast in terms of their populations, feature significant extractive industries, and feature higher emissions intensities. The construction sectors of western provinces are highly interconnected and receive a disproportionate proportion of embodied emissions from Alberta, whose high level of emissions promises to complicate decarbonization efforts. This article met the requirements for a gold‐gold JIE data openness badge described at http://jie.click/badges
Oxygen matters: Unraveling the role of oxygen in the neuronal response to cisplatin
Authors: Crugeiras Jose , Calls Aina , Contreras Estefanía , Alemany Montse , Navarro Xavier , Yuste Victor J. , Casanovas Oriol , Udina Esther , Bruna Jordi 
Published: September 2024

AbstractBackground and AimsCell culture is a fundamental experimental tool for understanding cell physiology. However, translating these findings to in vivo settings has proven challenging. Replicating donor tissue conditions, including oxygen levels, is crucial for achieving meaningful results. Nevertheless, oxygen culture conditions are often overlooked, particularly in the context of chemotherapy‐induced neurotoxicity.MethodsIn this study, we investigated the role of oxygen levels in primary neuronal cultures by comparing neuronal performance under cisplatin exposure (1 μg/mL) in supraphysiological normoxia (representing atmospheric conditions in a standard incubator; 18.5% O2) and physioxia (representing physiologic oxygen conditions in nervous tissue; 5% O2). Experiments were also conducted to assess survival, neurite development, senescence marker expression, and proinflammatory cytokine secretion.ResultsUnder control conditions, both oxygen concentration conditions exhibited similar behaviors. However, after cisplatin administration, sensory neurons cultured under supraphysiological normoxic conditions show higher mortality, exhibit an evolutionarily proinflammatory cytokine profile over time, and activate apoptotic‐regulated neuron death markers. In contrast, under physiological conditions, neurons treated with cisplatin exhibited senescence marker expression and an attenuated inflammatory secretome.InterpretationThese results underscore the critical role of oxygen in neuronal culture, particularly in studying compounds where neuronal damage is mechanistically linked to oxidative stress. Even at identical doses of evaluated neurotoxic drugs, distinct cellular phenotypic fates can emerge, impacting translatability to the in vivo setting.
Relationship between illness perception and self‐management behaviors among women with gestational diabetes mellitus in China during the COVID‐19 pandemic: A mediating role of depression
Authors: Wang Jiarun , Zhu Luyang , An Ran , Chen Yujia , Pan Xinlong , Zhang Wei , Chen Xiaoli , Zou Zhijie , Zhang Yingzi 
Published: September 2024

AbstractObjectiveDescribe the current status of illness perception, depression, and self‐management behaviors among women with gestational diabetes mellitus (GDM) during the COVID‐19 pandemic, and explore the role of depression in the relationship between illness perception and self‐management behaviors among women with GDM.MethodsPregnant women diagnosed with GDM were recruited at the obstetrics clinic of a Grade‐A tertiary hospital in Wuhan, through convenience sampling. Self‐reported questionnaires including basic information, illness perception, depression, and self‐management behaviors were used to collect data from April 2021 to February 2022. Mediation analysis was performed by SPSS Process macro.ResultsAmong GDM pregnant women, the mean self‐management behaviors score was 73.89 (SD = 12.21), the mean illness perception score was 31.80 (SD = 8.77), and 44.3% had depression scores of 10 or higher. The indirect effect of illness perception on self‐management behaviors mediated by depression was significant (path a * b, β = −0.045), accounting for 26.6% of the total effect.ConclusionGDM pregnant women have a certain negative illness perception of GDM, and the detection rate of depression symptoms is relatively high. The level of self‐management behaviors among GDM pregnant women is notably suboptimal and warrants improvement. Depression partially mediates the relationship between illness perception and self‐management behaviors. Improving positive illness perception and decreasing depression are important strategies to improve self‐management behaviors in women with GDM.
Association of lipid levels at different stages of pregnancy with gestational diabetes mellitus and the incidence of neonatal macrosomia: A retrospective study
Authors: Wang Xuechun , Wu Lili , Luo Haimeng , Zhong Wenxuan , Zheng Xiuqiong , Xu Rongli 
Published: September 2024

AbstractObjectiveTo investigate the correlation between lipid levels during gestation and the incidence rate of gestational diabetes mellitus (GDM) and macrosomia.MethodClinical records of 607 pregnant women with GDM (GDM group) who delivered in the Obstetrics Department of Fujian Maternal and Child Health Hospital from May to December 2018 and of 833 women with uncomplicated pregnancies (control group) were retrospectively analyzed. After delivery, the entire cohort was further grouped based on the weight of the neonates: women who delivered newborns with body mass <4 kg comprised the normal group (n = 1367), and pregnancies that resulted in delivery of neonates with body mass >4 kg were classified as the macrosomia group (n = 73). Fasting serum levels of triglycerides (TG), total cholesterol (TC), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), and TG/HDL‐C ratio were compared between the groups at the early (10–12 weeks), middle (24–28 weeks), and late (28 weeks‐delivery) stages of pregnancy, and the correlation between the lipid indices and the rates of GDM and macrosomia were analyzed.ResultsThere was a gradual increase in TC, TG, LDL‐C, and TG/HDL‐C levels with increasing gestational weeks in pregnant women. TG and TG/HDL‐C levels were markedly higher, while HDL‐C was lower in women with GDM compared with women of the same gestational age with uncomplicated pregnancies (p < 0.05).ConclusionLipid metabolism disorders exist in pregnant women with GDM at different gestational stages and are closely related to the higher incidence of macrosomia. TG, TG/HDL‐C, and HDL‐C in early and late pregnancy are independent risk factors for macrosomia in all trimesters, and TG/HDL‐C ratio at different gestational stages has a good predictive value for macrosomia.
Judicial relational legal consciousness: authoritarian backsliding as a catalyst of change
Authors: KUBAL AGNIESZKA 
Published: September 2024

AbstractBetween 2015 and 2023, authoritarian backsliding triggered significant changes in the Polish judiciary, prompting some judges to adopt a new approach in their interpretation of the European Convention on Human Rights, both on and off bench, taking a more explicit stance as individual applicants against the Polish government in the European Court of Human Rights. This article employs the paradigm of relational legal consciousness, attributing this embrace of human rights law to judges’ interactions and relationships with various actors, including judicial associations, lawyers, human rights activists, and civil society. Furthermore, the article extends the concept of relationality in legal consciousness to encompass the intricate interplay between law and politics as intertwined social relations and practices. The article's original contribution lies in theorizing judicial legal consciousness in relation to authoritarian backsliding and the resultant liminality of structures and strategies for action.
Governmental influence over rights consciousness: public perceptions of the COVID‐19 lockdown
Authors: HALLIDAY SIMON , JONES ANDREW , MEERS JED , TOMLINSON JOE 
Published: September 2024

AbstractA focus on rights consciousness has become a mainstay of the socio‐legal study of law in everyday life. Such research, much of it critical in orientation, generally uses people's sense of grievance as its starting point. The consequent risk is that we elide rights consciousness with a sense of injustice. This article argues that there is merit for critical studies of legal consciousness in keeping these two things separate, and that this represents a dimension of the critical approach to rights consciousness that is largely missing from the field. We present a study of rights consciousness in relation to the imposition of lockdown in the United Kingdom during the early stage of the COVID‐19 pandemic. We show that, despite regarding lockdown as a violation of basic rights, most people did not feel a sense of grievance. Furthermore, rights consciousness was influenced by a range of factors distinct from political orientation, most of which were within the sphere of governmental influence. In this way, governmental power was constitutive of the public's rights consciousness. Further exploration and assessment of when, where, and how this might occur should be part of the critical project of legal consciousness research.
Development of Loop‐Mediated Isothermal Amplification (LAMP) Kit for the Detection of Fusarium Wilt Using SIX8 Genes
Authors: Canare Perry Lorraine Duran , Uy Roselyn Jove , Konishi Shinju , Tonami Hana , Alvindia Dionisio G. , Nakashima Chiharu 
Published: September 2024

ABSTRACTPanama disease, or Fusarium wilt, is a soil‐borne fungal disease of Musa spp. and the most severe threat to the banana industry and food security worldwide with no cure. Therefore, early detection of the pathogen Fusarium oxysporum f. sp. cubense (Foc) through reliable diagnostics will aid in implementing plant quarantine and containment measures to prevent the spread of this disease. In this study, a primary diagnostic procedure was developed based on the DNA sequences of the Foc‐TR4 SIX8a homologue, extracted from a piece of pseudostem tissue of M. acuminata Gros Michel Subgroup from Japan. A set of primers for the loop‐mediated isothermal amplification (LAMP) reaction was designed. The developed specific marker can be used to accurately, rapidly, and reliably detect early diagnosis of Foc‐TR4 infection without cutting down the unconfirmed young plant in banana fields.
Open label clinical trial of orally administered molnupiravir as a first‐line treatment for naturally occurring effusive feline infectious peritonitis
Authors: Reagan Krystle L. , Brostoff Terza , Pires Jully , Rose Amy , Castillo Diego , Murphy Brian G. 
Published: September 2024

AbstractBackgroundBefore the discovery of effective antiviral drugs, feline infectious peritonitis (FIP) was a uniformly fatal disease of cats. Multiple antiviral treatments have been recognized, but optimization of treatment protocols is needed.ObjectiveTo evaluate the efficacy of PO molnupiravir (MPV; EIDD‐2801) to treat effusive FIP.AnimalsTen cats with naturally occurring effusive FIP and 10 historical control cats with effusive FIP treated with PO GS‐441524.MethodsA single‐center, prospective, open‐label longitudinal, non‐inferiority trial with historical controls. Ten cats with FIP were enrolled and treated with PO MPV (10‐15 mg/kg PO q12h) for 84 days. Cats were evaluated at 0, 6, and 16 weeks, and the proportion of cats in clinical remission at 16 weeks was determined. Survival and clinicopathologic features were compared with historical control cats with effusive FIP treated with PO GS‐441524.ResultsEight of the 10 cats treated with MPV survived and were in remission at 16 weeks. The 2 non‐survivors died in the first 24 hours of treatment. No adverse events that necessitated discontinuation of treatment were observed. Survival of cats treated with PO MPV was non‐inferior to historic control cats treated with PO GS‐441524 (5/9 [55%] survived), with a difference in survival of 25% (90% confidence interval, −9.3% to 59.3%). Clinicopathologic features associated with FIP normalized during the study period, and no differences in clinicopathologic data at each study time point were observed when comparing cats treated with MPV and GS‐441524.Conclusions and Clinical ImportanceMolnupiravir is an effective antiviral treatment for effusive FIP.
Longitudinal Development of Holistic Formulaicity, Formulaic Sequences, and Lexical Complexity in Sojourner Diaries: A Dynamic Usage‐Based Perspective
Authors: Köylü Zeynep , Eryılmaz Nurullah , Pérez‐Vidal Carmen , Verspoor Marjolijn , Gustafsson Hana 
Published: September 2024

AbstractBecause of authentic exposure, study‐abroad sojourners are expected to become more proficient in terms of holistic formulaicity (defined as targetlike language use of intensifiers, fillers, multiword sequences, lexical features, verb–argument constructions, pragmatic and discourse features, and so on), use of formulaic sequences, and lexical measures. This study traces the development of these constructs over time in written diary texts of 26 Catalan/Spanish bilingual sojourners in an Anglophone country during study abroad. It adopts a dynamic usage‐based perspective, underlining the importance of frequency of exposure and individual variability in developmental trajectories. Generalized additive mixed model analyses, which take individual nonlinear behavior into account, showed significant gains toward holistic formulaicity, but not in use of formulaic sequences nor in lexical complexity measures. We argue that at advanced stages some measures may have reached ceiling, but that sojourners may still progress in becoming more finely attuned to the conventionalized ways of saying things in the speech community.
Overview of Lymphatic Muscle Cells in Development, Physiology, and Disease
Authors: Arroyo‐Ataz Guillermo , Jones Dennis 
Published: September 2024

ABSTRACTLymphatic muscle cells (LMCs) are indispensable for proper functioning of the lymphatic system, as they provide the driving force for lymph transport. Recent studies have advanced our understanding of the molecular mechanisms that regulate LMCs, which control rhythmic contraction and vessel tone of lymphatic vessels—traits also found in cardiac and vascular smooth muscle. In this review, we discuss the molecular pathways that orchestrate LMC‐mediated contractility and summarize current knowledge about their developmental origin, which may shed light on the distinct contractile characteristics of LMCs. Further, we highlight the growing evidence implicating LMC dysregulation in the pathogenesis of lymphedema and other diseases related to lymphatic vessel dysfunction. Given the limited number and efficacy of existing therapies to treat lymphedema, LMCs present a promising focus for identifying novel therapeutic targets aimed at improving lymphatic vessel contractility. Here, we discuss LMCs in health and disease, as well as therapeutic strategies aimed at targeting them to improve lymphatic vessel function.