bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality Improvement Initiatives to Optimize the Management of Chronic Obstructive Pulmonary Disease in Patients With Lung Cancer
Authors: Digby Geneviève C. , Robinson Andrew 
Published: August 2017

Purpose: Patients with lung cancer (LC) frequently have chronic obstructive pulmonary disease (COPD), the optimization of which improves outcomes. A 2014 Queen’s University Hospitals audit demonstrated that COPD was underdiagnosed and undertreated in outpatients with LC. We sought to improve the diagnosis and management of COPD in this population. Methods: We implemented change using a Define/Measure/Analyze/Improve/Control (DMAIC) improvement cycle. Data were obtained by chart review from the Cancer Care Ontario database and e-Patient System for patients with newly diagnosed LC, including patient characteristics, pulmonary function test (PFT) data, and bronchodilator therapies. Improvement cycle 1 included engaging stakeholders and prioritizing COPD management by respirologists in the Lung Diagnostic Assessment Program. Improvement cycle 2 included physician restructuring and developing a standard work protocol. Data were analyzed monthly and presented on statistical process control P-charts, which assessed differences over time. The χ2 and McNemar tests assessed for significance between independent and dependent groups, respectively. Results: A total of 477 patients were studied (165 patients at baseline, 166 patients in cycle 1, and 127 patients in cycle 2). There was no change in PFT completion over time, although respirology-managed patients were significantly more likely to undergo a PFT than patients who were not managed by respirology (56.7% v 96.1%; P < .00001). The proportion of respirology-managed patients with LC with airflow obstruction receiving inhaled bronchodilator significantly increased (baseline, 46.3%; cycle 1, 51.0%; and cycle 2, 74.3%). By cycle 2, patients with airflow obstruction were more likely to receive a long-acting bronchodilator if managed by respirology (74.3% v 44.8%; P = .0009). Conclusion: COPD is underdiagnosed and undertreated in outpatients with LC. A DMAIC quality improvement strategy emphasizing COPD treatment during LC evaluation in the Lung Diagnostic Assessment Program significantly improved COPD management.
The Golgi entry core compartment functions as a COPII-independent scaffold for ER-to-Golgi transport in plant cells
Authors: Ito Yoko , Uemura Tomohiro , Nakano Akihiko 
Published: August 2017

ABSTRACT
Many questions remain about how the stacked structure of the Golgi is formed and maintained. In our previous study, we challenged this question using tobacco BY-2 cells and revealed that, upon Brefeldin A (BFA) treatment, previously undescribed small punctate structures containing a particular subset of cis-Golgi proteins are formed adjacent to the ER-exit sites and act as scaffolds for Golgi regeneration after BFA removal. In this study, we analyzed these structures further. The proteins that localize to these punctate structures originate from the cis-most cisternae. 3D time-lapse observations show that the trans-Golgi marker is transported through these structures during Golgi regeneration. These data indicate that the cis-most cisternae have a specialized region that receives cargo from the ER, which becomes obvious upon BFA treatment. Expression of a dominant mutant form of SAR1 does not affect the formation of the punctate structures. We propose to call these punctate structures the ‘Golgi entry core compartment’ (GECCO). They act as receivers for the rest of the Golgi materials and are formed independently of the COPII machinery.
This article has an associated First Person interview with the first author of the paper.
Objects: Methods of documenting social change
Authors: Winenciak Katarzyna 
Published: August 2017

Abstract
The aim of this article is to show how photography evidenced social changes in Polish history between 1959 and 2016. It focuses on the problem of documenting average items instead of photo reportage. It presents the pictures created in a variety of political realities: including the communist period in Poland and the years after 1989. By presenting projects of artists Władysław Hasior and Zbigniew Dłubak two different photographic practitioners work are shown. They both were able to see and document changes in the political reality of their time. After the fall of Communism the photographers draw attention to the documentation of ‘neutral’ objects once again. Polish New Documentarists continued earlier actions, but also created their work in the changed realities of the period. They practice what Edouard Pontremoli called ‘the aesthetic of dullness’(Pontremoli: 2006, 162). This article discusses how seemingly objective photographs become a part of the evidence of historical events.
Hubungan Paparan Timbal Dalam Darah dengan Kejadian Hipertensi Pada Pekerja Industri Pengecoran Logam Di Ceper Klaten Tahun 2015
Authors: Ambarwanto Sigit Tri , Nurjazuli Nurjazuli , Raharjo Mursid 
Published: August 2017

Background: The problem of heavy metal pollution is a serious problem in Indonesia. This metal has been known to be stored in the body for long periods of time as toxins accumulate. Preliminary test results BLL on workers in the metal casting Ceper, found as many as 16 (5.61%) BLL on workers is under (NAB) and 17 (5.28%) workers above (NAB). The research was conducted to determine the relationship between the exposure of lead (Pb) in blood with hypertension in foundry workers CV. Fortification Jaya Batur, Ceper, Klaten. Methods: It was an observational study with Cross Secional design. The population in this study were all workers CV. Jaya fortification. Samples are workers CV. Fortification Jaya who met the inclusion criteria. Gathering data using questionnaires tools, inspection PB in the air using Gravimetry, Pb in the blood examination using AAS (automatic Absorption Spectrophotometer) and hypertension examination tension meter is measured using a needle. Results: The average air Pb 0.13756 mg / dl, the average BLL was 14.38096μg/dl. Chi Square test results showed that there was no relationship between the type of work with hypertension (p = 0.625), There is a relationship between levels of air Pb Pb levels in blood (p = 0.019), There is a relationship between levelsof lead in blood with hypertension(p=0.042).Conclusions:Levels of Air Pb Pb levels in the blood affects that can cause hypertension. Keywords: Hypertension, Blood Lead Level, Klaten
Molecular identification of drug resistant mutations to tetracycline in Mycoplasma spp. isolated from patients with multiple sclerosis
Authors: Naghib M. , Kheirkhah B. , Mohebbi R. , Sadeg L. 
Published: August 2017

Bacterial infections play a significant role in causing or intensifying the attacks in MS and there are reports based on the interference of Mycoplasma with a global distribution. Mycoplasma causes autoimmune attacks by imitating the host cell membrane, which is a way of resistance to antibiotics. The purpose of this study was to evaluate the molecular identification of mutations causing resistance to tetracycline in Mycoplasma isolated from MS patients. A total number of 32 cerebrospinal fluid samples and 48 urinal fluid samples were collected from MS patients. The samples were enriched in 7 PPLO broth for one night and continuous cultivation in agar PPLO and PPLO broth for one week. DNA was extracted, and then nested PCR and Doublex PCR were used for bacteria genus identification and the presence of potential tetracycline-resistant alleles (rrs4 and rrs3), respectively. A total number of 12 samples created colonies. However, only 5 samples (1 cerebrospinal fluid and 4 urinal samples) were detected to be Mycoplasma. The urinal samples showed the desired alleles and were tetracycline-resistant. By sequencing the PCR products, it was shown that these alleles have mutated in various points. Based on the results it seems that the resistant mutated Mycoplasma can be detected in MS patients in our population and may be considered as a risk factor for the disease.
Effects of curcumin plus Soy oligosaccharides on intestinal flora of rats with ulcerative colitis
Authors: Huang G. , Ye L. , Du G. , Huang Y. , Wu Y. , Ge S. , Yang Z. , Zhu G. 
Published: August 2017

To explore the therapeutic effect of curcumin (Cur) and soybean oligosaccharides (SBOS) on ulcerative colitis (UC) through testing the intestinal flora and ulcerative colitis (UC). 80 male SD rats were selected divided into four groups with 20 rats in each group: normal group, sulfasalazine (SASP) group, model group and group of curcumin plus soy oligosaccharide. All animals were treated for 4 weeks. In the fifth week rats were decapitated. Macroscopic damage scores of colonic mucosa were calculated. A 4mL blood sample was taken to detect the contents of serum tumor necrosis factor -Î± (TNF-Î±) and interleukin 8 (IL-8) by the double antibody sandwich ABC-ELISA method (enzyme-linked immunosorbent assay). Colonic tissues with the most obvious lesions were obtained using a surgical scissor. A routine hematoxylin-eosin (HE) staining method was used to stain pathological specimens and images of staining results were obtained. Histological injury scores of colonic mucosa were calculated. Ulcerative colitis model rats had the highest macroscopic damage scores and histological injury scores of colonic mucosa. After treatment the contents of TNF-Î± and IL-8 decreased significantly in the group of curcumin plus soy oligosaccharide compared with the model group with statistical significance (P <0.01) while the contents were close to those in the SASP group. There was no statistical significance (P> 0.05). The treatment could decrease TNF-Î± and IL- 8 expression and reduce colonic mucosa inflammation and tissue damage.
Tandem repeats detection in DNA sequences using Kaiser window based adaptive S-transform
Authors: Sharma Sunil Datt , Saxena Rajiv , Sharma Sanjeev Narayan 
Published: August 2017

Abstract
In computational biology the development of algorithms for the identification of tandem repeats in DNA sequences is a challenging problem. Tandem repeats identification is helpful in gene annotation, forensics, and the study of human evolution. In this work a signal processing algorithm based on adaptive S-transform, with Kaiser window, has been proposed for the exact and approximate tandem repeats detection. Usage of Kaiser window helped in identifying short as well as long tandem repeats. Thus, the limitation of earlier S-transform based algorithm that identified only microsatellites has been alleviated by this more versatile algorithm. The superiority of this algorithm has been established by comparative simulation studies with other reported methods.
Development accounting with intermediate goods
Authors: Grobovšek Jan 
Published: August 2017

AbstractI use a simple development accounting framework that distinguishes between goods and service industries on the one hand, and final and intermediate output on the other hand, to document the following facts. First, poorer countries are particularly inefficient in the production of intermediate relative to final output. Second, they are not necessarily inefficient in goods relative to service industries. Third, they present low measured labor productivity in goods industries because these are intensive intermediate users, and because their intermediate TFP is relatively low. Fourth, the elasticity of aggregate GDP with respect to sector-neutral TFP is large.
Nullity and Other Defects of Administrative Decisions in the Czech Republic
Authors: Frumarová Kateřina 
Published: August 2017

Abstract
This article deals with the issue of administrative decision, which represents one of the principal forms of the realization of public administration in the Czech Republic. Even if the Czech legislation provides for its issuance a number of requirements in relation to its content and form, in practice, however, there are violations of these legal conditions and requirements and then we talk about a defective administrative decision. According to how to remedy the defective administrative acts, distinction is made between formally defective administrative decisions, factually inaccurate decisions, unlawful decisions, and next to them, separately null administrative decisions. The main attention is paid to the nullity, because only the nullity represents the most serious and also irremovable defect of an administrative decision. As the null decision does not exist from the perspective of law, it is not able to affect the rights and duties of its recipients. The null acts, as the only category of defective administrative acts, constitute an exception to the principle of the presumption of validity and correctness of administrative acts.
Access to Archives in Post-Communist Countries: The Victim’s Perspective
Authors: Gruodytė Edita , Gervienė Silvija 
Published: August 2017

Abstract
The collapse of the communist regime at the end of the twentieth century resulted in a wave of democratization in Central and Eastern Europe. While trying to establish democracy, many states in this region had to demonstrate their ability to protect human rights and to deal with the past of the repressive regime. As these states decided to join various human rights instruments they also became subject to certain obligations towards their people. One of these obligations is the requirement to provide remedies in case of human rights abuses, and the right to know the truth is recognized as part of it. Therefore the goal of this article is to identify the abilities of the victim of the communist regime to access the files of former secret services in post-communist countries in the light of the right to know the truth. The answer is provided using an analysis of international documents, historic, comparative and systemic methods, providing and evaluating the practice of different states dealing with the files of former secret services or government files of the repressive past and academic literature.
Protein kinase C-α and the regulation of diverse cell responses
Authors: Singh Rishi Kant , Kumar Sanjay , Gautam Pramod Kumar , Tomar Munendra Singh , Verma Praveen Kumar , Singh Surya Pratap , Kumar Sanjay , Acharya Arbind 
Published: August 2017

AbstractProtein kinase C (PKC) comprises a family of lipid-sensitive enzymes that have been involved in a broad range of cellular functions. PKC-α is a member of classical PKC with ubiquitous expression and different cellular localization. This unique PKC isoform is activated by various signals which evoke lipid hydrolysis, after activation it interacts with various adapter proteins and is localized to specific cellular compartments where it is devised to work. The universal expression and activation by various stimuli make it a perfect player in uncountable cellular functions including differentiation, proliferation, apoptosis, cellular transformation, motility, adhesion and so on. However, these functions are not intrinsic properties of PKC-α, but depend on cell types and conditions. The activities of PKC-α are managed by the various pharmacological activators/inhibitors and antisense oligonucleotides. The aim of this review is to elaborate the structural feature, and provide an insight into the mechanism of PKC-α activation and regulation of its key biological functions in different cellular compartments to develop an effective pharmacological approach to regulate the PKC-α signal array.
Challenges in the analysis of epigenetic biomarkers in clinical samples
Authors: García-Giménez José Luis , Mena-Mollá Salvador , Beltrán-García Jesús , Sanchis-Gomar Fabian 
Published: August 2017

AbstractEpigenetic modifications represent an interesting landscape which can describe relevant features of human disease. Epigenetic biomarkers show several advantages as disease biomarkers because they provide information about gene function, specific endophenotypes and can even incorporate information from the environment and the natural history of disease. The improvement in genomic and epigenomic technologies has revolutionized the current comprehension of biological processes underlying health and disease. However, now is the time to adopt these new technologies to improve human health, thus converting this information into reliable biomarkers. This endeavor should be focused on improving methodologies to analyze gene methylation, histone modifications and microRNAs. Ideally, epigenetic biomarkers should be robust, routine, accurate and inexpensive in order to provide better information for patient diagnosis, prognosis, stratification and treatment monitoring. Here we describe some challenges and provide strategies to improve the adoption of epigenetic biomarkers into clinical routine. Furthermore, we summarize the recommended properties for clinical epigenetic biomarkers.
Pyrrolidinium salt based binary and ternary deep eutectic solvents: green preparations and physiochemical property characterizations
Authors: Wang Jing , Baker Sheila N. 
Published: August 2017

Abstract
Ionic liquids (ILs) are considered to be green solvents for various applications. However, their synthesis via chemical reaction with by-products or waste produced is contradictory to the concept of green chemistry, and the purity problem and economic feasibility limit their applications in some large-scale industrial applications. 1-Butyl-1-methylpyrrolidinium bromide ([bmpy][Br]), which is a molten salt with melting point above 100°C is a precursor of pyrrolidinium ILs, but hardly can be put under the category of IL because of its high melting point. In this study, [bmpy][Br] based binary deep eutectic solvent (BDES) and ternary deep eutectic solvent (TDES) were synthesized to prepare [bmpy][Br] in liquid form. During the preparation process, no reaction media was employed, no by-product was generated, and no further purification was required, thereby making it a completely green process. The prepared TDES has better thermal stability and larger free volume than BDES, which is potentially useful for sorption applications with high temperature requirement. It is also because of the green preparation process that the TDES is also expected to be capable for the large-scale industrial applications. This work is opening up new avenues for the study of binary and ternary IL-DES system and their applications.
Pore analysis of thermally compressed Scots pine (Pinus sylvestrisL.) by mercury intrusion porosimetry
Authors: Li Lili , Wang Ximing , Yan Yan , Ping Lijuan 
Published: August 2017

AbstractIn focus of the present study was the mercury intrusion porosimetry (MIP) of heartwood (hW) and sapwood (sW) of Scots pine, which were modified by compression alone (C) and combination of C and heat treatment (CHT). The untreated sW has a more uniform pore distribution than that of hW as presented in logarithmic differential curves. Expectedly, the total pore volumes of CHThW and CHTsW are significantly decreased. Compared to the HT temperature (180–220°C), the exposure time (2–5 h) has a weaker effect on the pore structures of the CHT woods. Furthermore, the intrusion volume of CHThW decreased compared with compressed alone samples. However, an inverse result was apparent for CHTsW.
Subjective social status and its relationship to health and health behavior: comparing two different scales in university students
Authors: Diehl Katharina , Hoebel Jens , Sonntag Diana , Hilger Jennifer 
Published: August 2017

Abstract

Background
Little is known about the relationship between socioeconomic status (SES) and health in late adolescence. As it is difficult to measure SES in this age group directly, we used two subjective social status (SSS) scales with different reference groups for social comparison in the relatively homogeneous group of university students and analyzed the relationship with health and health behaviors.

Methods
We used two 10-rung ladders, a societal and a university one, to measure SSS in students (n = 689, 16–29 years). We compared the scales’ ratings and analyzed relationships with sociodemographic factors, health outcomes and behaviors.

Results
On average, students rated their individual SSS higher on the university scale (6.87) than on the societal one (6.41). Regarding health outcomes and behaviors, we found similar results for both scales, while sociodemographic variables were more likely to be associated with the societal scale.

Conclusion
SSS seems to be a useful measure besides the objective SES. Our data suggest that both SSS scales are helpful in the framework of health inequality but differ slightly in what they measure. More detailed research may help to determine which scale is appropriate for individual study context.
40 Gbps Downstream Transmission Using DQPSK and 20 Gbps Upstream Transmission Using IRZ Modulation in Full-Duplex WDM-PON
Authors: Das Binoy , Mukherjee Rahul , Mandal Gour Chandra , Patra Ardhendu Sekhar 
Published: August 2017

AbstractA full duplex WDM-PON system is designed and demonstrated based on carrier reusing scheme and by employing differential quadrature phase shift keying (DQPSK) modulation in downlink and inverse return-to-zero modulation in the uplink to transmit 40 Gbps and 20Gbps data-rate respectively. Three Mach-Zehnder modulators are used sequentially to realize the 67 % carrier suppressed return to zero (CS-RZ) DQPSK modulation in the downlink transmission. Very low bit error rate values @10‒9and clear eye-diagrams are observed over a 40 km single-mode-fiber transmission in our proposed full-duplex configuration.
Bat diversity in the western Brazilian Pantanal
Authors: Bordignon Marcelo Oscar , Shapiro Julie Teresa 
Published: August 2017

Abstract
Located in southwestern Brazil, the Pantanal is a Wetland of International Importance and Biosphere reserve. It is composed of several subregions, each with distinct vegetation, and hosts diverse bat fauna. The goal of this study was to compare the bat communities between different subregions of the Pantanal, especially poorly sampled areas. From February 2008 to November 2009, we surveyed bats using mist nets at five sites with different vegetation structure and hydrology, over an area of 30,000 km2. Fecal samples were also collected. We captured 254 bats belonging to six families and 37 species: Phyllostomidae (19), Vespertilionidae (8), Molossidae (8), Noctilionidae (1), Emballonuridae (1) and Natalidae (1). The most abundant species was Artibeus planirostris (32%). The species reported in this study represent 60% of bat species recorded in Mato Grosso do Sul and 71% of species known from the Pantanal region of the state. We also highlight important records for the Pantanal, including Eumops patagonicus, Eptesicus diminutus and Micronycteris sanborni. The most common plant species in the feces of bats were from the genera Cecropia and Ficus. The community of bats in the Pantanal proved rich and diverse, with differences among subregions, possibly reflecting their complex landscape and different habitats.