bluuebunny/crossref_metadata_2025_split huggingface dataset:
VP192 Importance Of Contextual Data In Producing Health Technology Assessment Recommendations
Authors: Poder Thomas , Bellemare Christian 
Published: January 2018

INTRODUCTION:Available data in the scientific literature is not always sufficient to make a clear Health Technology Assessment (HTA) recommendation without any other source of data. Contextual data and local expertize are an important source of data that cannot be ignored in HTA process. Despite a lack of evidence in the scientific literature, a technology can be recommended in a given context. We illustrate this by a case study about biplane angiography for vascular neurointervention.METHODS:A systematic review was conducted. The level of evidence was assessed by the grid of Downs and Black. An analysis of the context in our setting was also conducted. The main outcomes were: radiation doses, clinical complications, procedure times, purchase cost, impact on teaching programs, confidence of clinicians in the technology, quality of care, and volume of activity. A committee constituted of managers, clinical experts, physicians, physicists and HTA experts was created to produce a recommendation about biplane technology acquisition.RESULTS:A list of 257 citations was obtained yielding 9 eligible articles for analysis. Despite the lack of evidence found in the literature (median of Downs and Black: 3/32), the biplane system appears to reduce ionizing radiation and medical complications as well as shorten procedure time. Contextual data indicated that biplane system could improve operator's confidence, which could translate into reduced risk, especially for complex procedures. We estimate that a minimum of 50 cases can be done in our context (University hospital center covering a population of 306,322 people) with a higher level of patient safety. In addition, the biplane system can support our institution in advanced procedures teaching program.CONCLUSIONS:Given on the advantages provided by the biplane technology in our setting, the committee has recommended its acquisition. However, this technology should be implemented with a responsibility in collecting outcome data to optimize clinical protocol in doses of ionizing delivered.
VP205 Implementing Electronic Records In Ambulances
Authors: Porter Alison , Black Sarah , Dale Jeremy , Fitzpatrick David , Harris-Mayes Robert , Lawrenson Robin , Lyons Ronan , Mason Suzanne , Morrison Zoe , Mountain Pauline , Potts Henry , Siriwardena Niro , Rees Nigel , Snooks Helen , Williams Victoria 
Published: January 2018

INTRODUCTION:Increasingly, ambulance services offer alternatives to transfer to the emergency department (ED), when this is better for patients. The introduction of electronic health records (EHR) in ambulance services is encouraged by national policy across the United Kingdom (UK) but roll-out has been variable and complex.Electronic Records in Ambulances (ERA) is a two-year study which aims to investigate and describe the opportunities and challenges of implementing EHR and associated technology in ambulances to support a safe and effective shift to out of hospital care, including the implications for workforce in terms of training, role and clinical decision-making skills.METHODS:Our study includes a scoping review of relevant issues and a baseline assessment of progress in all UK ambulance services in implementing EHR. These will inform four in-depth case studies of services at different stages of implementation, assessing current usage, and examining context.RESULTS:The scoping review identified themes including: there are many perceived potential benefits of EHR, such as improved safety and remote diagnostics, but as yet little evidence of them; technical challenges to implementation may inhibit uptake and lead to increased workload in the short term; staff implementing EHR may do so selectively or devise workarounds; and EHR may be perceived as a tool of staff surveillance.CONCLUSIONS:Our scoping review identified some complex issues around the implementation of EHR and the relevant challenges, opportunities and workforce implications. These will help to inform our fieldwork and subsequent data analysis in the case study sites, to begin early in 2017. Lessons learned from the experience of implementing EHR so far should inform future development of information technology in ambulance services, and help service providers to understand how best to maximize the opportunities offered by EHR to redesign care.
CHC Model According to Weiss
Authors: Pezzuti Lina , Lang Margherita , Rossetti Serena , Michelotti Clara 
Published: January 2018

Abstract. The Italian version of the Wechsler Adult Intelligence Scale – Fourth Edition (WAIS-IV) – was standardized using a sample of 2,174 participants, aged between 16 and 90 years. The WAIS-IV consists of 10 core subtests and 5 supplemental subtests. While the 70–90 yr group is usually excluded from three of the five supplemental subtests (Letter-Number Sequencing, Figure Weights, and Cancellation), we administered all 15 subtests both to adults and elderly people. The aim of the present study was to investigate the factorial invariance of the Weiss and colleagues’ hierarchical five-factor CHC (Cattell-Horn-Carroll) model in Italian adults and elders. The overall results of this study generally support both the configural and factorial invariance of the WAIS-IV, and hence the five-factor CHC model of Weiss is equivalent in adults and elderly people. However, for the elderly sample we found higher loadings of WAIS-IV subtests on the second-order g factor.
Rotator side chains trigger cooperative transition for shape and function memory effect in organic semiconductors
Authors: Chung Hyunjoong , Dudenko Dmytro , Zhang Fengjiao , D’Avino Gabriele , Ruzié Christian , Richard Audrey , Schweicher Guillaume , Cornil Jérôme , Beljonne David , Geerts Yves , Diao Ying 
Published: January 2018

AbstractMartensitic transition is a solid-state phase transition involving cooperative movement of atoms, mostly studied in metallurgy. The main characteristics are low transition barrier, ultrafast kinetics, and structural reversibility. They are rarely observed in molecular crystals, and hence the origin and mechanism are largely unexplored. Here we report the discovery of martensitic transition in single crystals of two different organic semiconductors. In situ microscopy, single-crystal X-ray diffraction, Raman and nuclear magnetic resonance spectroscopy, and molecular simulations combined indicate that the rotating bulky side chains trigger cooperative transition. Cooperativity enables shape memory effect in single crystals and function memory effect in thin film transistors. We establish a molecular design rule to trigger martensitic transition in organic semiconductors, showing promise for designing next-generation smart multifunctional materials.
Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer
Authors: Kotagiri Nalinikanth , Cooper Matthew L. , Rettig Michael , Egbulefu Christopher , Prior Julie , Cui Grace , Karmakar Partha , Zhou Mingzhou , Yang Xiaoxia , Sudlow Gail , Marsala Lynne , Chanswangphuwana Chantiya , Lu Lan , Habimana-Griffin LeMoyne , Shokeen Monica , Xu Xinming , Weilbaecher Katherine , Tomasson Michael , Lanza Gregory , DiPersio John F. , Achilefu Samuel 
Published: January 2018

AbstractMost cancer patients succumb to disseminated disease because conventional systemic therapies lack spatiotemporal control of their toxic effects in vivo, particularly in a complicated milieu such as bone marrow where progenitor stem cells reside. Here, we demonstrate the treatment of disseminated cancer by photoactivatable drugs using radiopharmaceuticals. An orthogonal-targeting strategy and a contact-facilitated nanomicelle technology enabled highly selective delivery and co-localization of titanocene and radiolabelled fluorodeoxyglucose in disseminated multiple myeloma cells. Selective ablation of the cancer cells was achieved without significant off-target toxicity to the resident stem cells. Genomic, proteomic and multimodal imaging analyses revealed that the downregulation of CD49d, one of the dimeric protein targets of the nanomicelles, caused therapy resistance in small clusters of cancer cells. Similar treatment of a highly metastatic breast cancer model using human serum albumin-titanocene formulation significantly inhibited cancer growth. This strategy expands the use of phototherapy for treating previously inaccessible metastatic disease.
Universal type/subtype-specific antibodies for quantitative analyses of neuraminidase in trivalent influenza vaccines
Authors: Xu Kangwei , Li Changgui , Gravel Caroline , Jiang Zheng , Jaentschke Bozena , Van Domselaar Gary , Li Xuguang , Wang Junzhi 
Published: January 2018

AbstractBoth influenza viral hemagglutinin and neuraminidase can induce protective immune responses in humans. Although the viral hemagglutinin antigens have been quantified in influenza vaccines, the amounts of neuraminidase remain undetermined. Using comprehensive bioinformatics analyses of all neuraminidase sequences, we identified highly conserved and subtype-specific peptide epitopes within each of N1, N2 and type B neuraminidase groups. Mono-specific antibodies generated against these peptides bound to their respective subtype/type only while demonstrating remarkable specificity against the viral neuraminidase sequences without any cross-reactivity with allantoic and cellular proteins. Moreover, the subtype/type-specific antibodies were found not to interfere with one another when a mixture of vaccine samples was analysed. Importantly, immunoassay based on these antibodies can quantitatively determine neuraminidase in commercial trivalent vaccine samples. Analyses of vaccines from eight manufacturers using the same vaccine seeds revealed significant differences in neuraminidase levels. Specifically, while the ratio between neuraminidase and hemagglutinin in some products are found to be close 1/5, other products have a ratio of approximately 1/100, a level which is far below the theoretical ratio between neuraminidase and hemagglutinin in a virus. The antibody-based assays reported here could be of great value for better quality control of both monovalent and trivalent vaccines.
Variation at position 350 in the Chikungunya virus 6K-E1 protein determines the sensitivity of detection in a rapid E1-antigen test
Authors: Tuekprakhon Aekkachai , Nakayama Emi E. , Bartholomeeusen Koen , Puiprom Orapim , Sasaki Tadahiro , Huits Ralph , Luplertlop Natthanej , Kosoltanapiwat Nathamon , Maneekan Pannamas , Ariën Kevin K. , Shioda Tatsuo , Leaungwutiwong Pornsawan 
Published: January 2018

AbstractChikungunya virus (CHIKV), a mosquito-borne pathogen, consists of three genotypes: East/Central/South African (ECSA), West African (WA), and Asian. Although a current rapid immunochromatographic (IC) test detecting CHIKV E1-antigen showed high sensitivity to ECSA-genotype viruses, it showed poor performance against the Asian-genotype virus that is spreading in the American continents. To understand the basis for the low performance of this IC test against Asian-genotype virus, we re-examined the anti-CHIKV monoclonal antibodies (mAbs) used in the assay for their interaction with E1-antigen of the three CHIKV genotypes. We found that the reactivity of one mAb for Asian-genotype virus was lower than that for ECSA virus. Comparison of E1 amino acid sequences revealed that the ECSA virus used to generate these mAbs possesses glutamic acid (E) at position 350, in contrast to WA and Asian, which possess aspartic acid (D) at this position. Site-directed mutagenesis confirmed that the mutation altered mAb reactivity, since E-to-D substitution at position 350 in ECSA reduced recognition by the mAb, while D-to-E substitution at this position in Asian and WA increased affinity for the mAb. Taken together, these results indicate that residue 350 of the CHIKV 6K-E1 is a key element affecting the performance of this IC assay.
Diurnal cycle and seasonal variation of cloud cover over the Tibetan Plateau as determined from Himawari-8 new-generation geostationary satellite data
Authors: Shang Huazhe , Letu Husi , Nakajima Takashi Y. , Wang Ziming , Ma Run , Wang Tianxing , Lei Yonghui , Ji Dabin , Li Shenshen , Shi Jiancheng 
Published: January 2018

AbstractAnalysis of cloud cover and its diurnal variation over the Tibetan Plateau (TP) is highly reliant on satellite data; however, the accuracy of cloud detection from both polar-orbiting and geostationary satellites over this area remains unclear. The new-generation geostationary Himawari-8 satellites provide high-resolution spatial and temporal information about clouds over the Tibetan Plateau. In this study, the cloud detection of MODIS and AHI is investigated and validated against CALIPSO measurements. For AHI and MODIS, the false alarm rate of AHI and MODIS in cloud identification over the TP was 7.51% and 1.94%, respectively, and the cloud hit rate was 73.55% and 80.15%, respectively. Using hourly cloud-cover data from the Himawari-8 satellites, we found that at the monthly scale, the diurnal cycle in cloud cover over the TP tends to increase throughout the day, with the minimum and maximum cloud fractions occurring at 10:00 a.m. and 18:00 p.m. local time. Due to the limited time resolution of polar-orbiting satellites, the underestimation of MODIS daytime average cloud cover is approximately 4.00% at the annual scale, with larger biases during the spring (5.40%) and winter (5.90%).
Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency
Authors: Leipnitz Guilhian , Mohsen Al-Walid , Karunanidhi Anuradha , Seminotti Bianca , Roginskaya Vera Y. , Markantone Desiree M. , Grings Mateus , Mihalik Stephanie J. , Wipf Peter , Van Houten Bennett , Vockley Jerry 
Published: January 2018

AbstractMitochondrial complex I (CI) deficiency is the most frequent cause of oxidative phosphorylation (OXPHOS) disorders in humans. In order to benchmark the effects of CI deficiency on mitochondrial bioenergetics and dynamics, respiratory chain (RC) and endoplasmic reticulum (ER)-mitochondria communication, and superoxide production, fibroblasts from patients with mutations in the ND6, NDUFV1 or ACAD9 genes were analyzed. Fatty acid metabolism, basal and maximal respiration, mitochondrial membrane potential, and ATP levels were decreased. Changes in proteins involved in mitochondrial dynamics were detected in various combinations in each cell line, while variable changes in RC components were observed. ACAD9 deficient cells exhibited an increase in RC complex subunits and DDIT3, an ER stress marker. The level of proteins involved in ER-mitochondria communication was decreased in ND6 and ACAD9 deficient cells. |ΔΨ| and cell viability were further decreased in all cell lines. These findings suggest that disruption of mitochondrial bioenergetics and dynamics, ER-mitochondria crosstalk, and increased superoxide contribute to the pathophysiology in patients with ACAD9 deficiency. Furthermore, treatment of ACAD9 deficient cells with JP4-039, a novel mitochondria-targeted reactive oxygen species, electron and radical scavenger, decreased superoxide level and increased basal and maximal respiratory rate, identifying a potential therapeutic intervention opportunity in CI deficiency.
Detection of planet candidates around K giants. HD 40956, HD 111591, and HD 113996
Authors: Jeong G. , Lee B.-C. , Han I. , Omiya M. , Izumiura H. , Sato B. , Harakawa H. , Kambe E. , Mkrtichian D. 
Published: January 2018

Aims. The purpose of this paper is to detect and investigate the nature of long-term radial velocity (RV) variations of K-type giants and to confirm planetary companions around the stars.
Methods. We have conducted two planet search programs by precise RV measurement using the 1.8 m telescope at Bohyunsan Optical Astronomy Observatory (BOAO) and the 1.88 m telescope at Okayama Astrophysical Observatory (OAO). The BOAO program searches for planets around 55 early K giants. The OAO program is looking for 190 G–K type giants.
Results. In this paper, we report the detection of long-period RV variations of three K giant stars, HD 40956, HD 111591, and HD 113996. We investigated the cause of the observed RV variations and conclude the substellar companions are most likely the cause of the RV variations. The orbital analyses yield P = 578.6 ± 3.3 d, m sin i = 2.7 ± 0.6 MJ, a = 1.4 ± 0.1 AU for HD 40956; P = 1056.4 ± 14.3 d, m sin i = 4.4 ± 0.4 MJ, a = 2.5 ± 0.1 AU for HD 111591; P = 610.2 ± 3.8 d, m sin i = 6.3 ± 1.0 MJ, a = 1.6 ± 0.1 AU for HD 113996.
Tumores de hipófise: Considerações sobre 120 casos e revisão de literatura
Authors: Silva Santos Egmond Alves , Vasconcelos Fernandes Serra Marcus Vinícius Flores de Barros , Santos Filho Wenner Jorzino , Silva Dumont Paulo Augusto , Peres Abelardo José , Romero Paulo César , França Fontoura Emílio Afonso 
Published: January 2018

Resumo
Objetivo: Estudo retrospectivo dos pacientes com adenoma hipofisário atendidos no Serviço de Neurocirurgia do Conjunto Hospitalar do Mandaqui de São Paulo, SP. Pacientes e métodos: Foram estudados, retrospectivamente, 120 casos de tumores de hipófise atendidos entre janeiro de 1993 e maio de 2006. Os dados analisados foram idade, sexo, queixa principal, apresentação clínica, classificação radiológica, tipo histológico e complicações. Resultados: A idade dos pacientes variou de 5 a 69 anos (média de 40,2 anos). Foram 89 pacientes do sexo feminino e 31 do sexo masculino. O déficit visual foi a queixa principal e presente em 52% dos pacientes. Com relação à classificação radiológica: 5,4% foram classificados como Hardy II; 8,1% como Hardy III; 86,5% como Hardy IV. A via de acesso foi transesfenoidal sublabial em 113 pacientes. Apenas três pacientes necessitaram reabordagem do tumor por craniotomia e sete pacientes foram submetidos à craniotomia sem tentativa transesfenoidal. Os tumores foram diagnosticados como não-secretores em 21,6% dos pacientes, prolactinomas em 70,2% dos pacientes, secretor de GH em 5,4% e de ACTH e LH em 2,7% cada um. As principais complicações do tratamento cirúrgico foram diabetes insípido e fístula liquórica. Houve quatro óbitos no pós-operatório. Conclusões: A média etária foi de 40,2 anos; o sexo feminino foi mais acometido; a perda visual foi a principal queixa; a maioria dos pacientes se apresentou em grau IV da classificação de Hardy; o principal tipo histológico foi o prolactinoma; a via transesfenoidal sublabial foi suficiente para a maioria dos tumores.
Tratamento das complicações clínicas decorrentes de intervenções neurocirúrgicas: Parte I: Infecções, complicações de procedimentos específicos, complicações sistêmicas, cognitivas e outras complicações
Authors: Pereira Carlos Umberto , Silva Alcântara Marta Regina , Silva Santos Egmond Alves 
Published: January 2018

Resumo
Objetivo: Apresentar as complicações neurocirúrgicas que ocorrem com grande freqüência; apesar dos esforços para preveni-las, algumas são inevitáveis. Método: Analisaram-se as principais complicações decorrentes de procedimentos neurocirúrgicos e os tratamentos específicos, baseados em revisão literária e em experiência própria. Conclusão: O tratamento médico dessas complicações pode ser transitório ou definitivo da causa subjacente, conforme a evolução clínica do paciente.
Pseudoapêndice caudal associado a pé torto congênito: Relato de caso
Authors: Moreira Albuquerque Antônio Carlos , Barbosa Ramon Guerra , de Figueiredo Maria Fernanda Freitas , Cangussu Edson Wagner 
Published: January 2018

ResumoO apêndice caudal é uma rara anomalia congênita, localizada na região lombossacral. Classifica-se, segundo Dao e Netsky, em pseudoapêndice e apêndice caudal verdadeiro, com implicações prognósticas e terapêuticas. O apêndice caudal pode estar associado a outras anormalidades congênitas, sendo necessários exame físico detalhado e exames de imagem para diagnóstico e tratamento precoce das doenças concomitantes. Os autores relatam um caso de pseudoapêndice caudal lombossacro (fibrolipoma congênito), associado a pé torto congênito, em uma criança submetida a tratamento cirúrgico excisional do pseudoapêndice. Fez-se revisão da literatura sobre casos semelhantes e não foi encontrada descrição da associação com pé torto congênito.
Tratamento cirúrgico de emergência no acidente vascular cerebral isquêmico. Afinal, o que há de evidências?
Authors: Oliveira de Amorim Robson Luis , Paiva Wellingson Silva , Figueiredo Eberval Gadelha , de Andrade Almir Ferreira , Teixeira Manoel Jacobsen 
Published: January 2018

Resumo
Contexto: O manuseio dos pacientes com infarto cerebral isquêmico inclui várias abordagens de tratamento. O tratamento cirúrgico é raramente necessário, entretanto os médicos gerais, neurologistas e neurocirurgiões devem estar atentos para essa possibilidade. Objetivo: Esta revisão visa sistematizar o tratamento cirúrgico com base em evidências nos acidentes vasculares isquêmicos. Conclusões: Apesar da crescente pesquisa envolvendo os acidentes vasculares, a taxa de mortalidade após a tentativa de tratamento cirúrgico pouco se tem alterado nas últimas décadas. Questões como quando ou a quem indicar uma craniectomia descompressiva no infarto isquêmico hemisférico são motivos de controvérsias no âmbito neurocirúrgico, e os dados da literatura são pouco esclarecedores.
Papiloma do plexo coroide do ângulo pontocerebelar: Relato de caso
Authors: Esteves Silva Carla Maria , Castro Silva Elsa Margarida , Melo Pires Manuel Jorge Rocha , Giesta Ramos Cristina Maria , Paiva Pinheiro Célia Maria de , Silva Martins Valdemar Pereira , Carvalho Pereira Antonio Ernesto de 
Published: January 2018

Resumo
Contexto: Os papilomas dos plexos coroides (PPC) têm localização típica intraventricular pela sua relação com os plexos coroides. Apenas 9% dos PPC estão localizados no ângulo pontocerebelar (APC), mas estes estão, na sua maioria, em relação com os plexos coroides do quarto ventrículo que afloram dos orifícios de Luschka. Já foram, no entanto, descritos alguns casos raros de PPC sem qualquer relação com os plexos coroides, tanto na fossa posterior como, até mesmo, no canal raquidiano. A recorrência local é rara e ainda mais rara é a disseminação pelo neuroeixo via espaço subaracnoide. Objetivo: Apresentar um caso de PPC com características atípicas: localização no APC, mas sem relação com o plexo coroide do quarto ventrículo, invasão óssea local, disseminação extradural e irrigação a partir de ramos arteriais meníngeos. Foi encontrado um caso semelhante na literatura, descrito em 1999. Alertamos para as características atípicas do PPC que poderão estar relacionadas com o diferente comportamento que este caso apresentou e que deve merecer uma reflexão sobre a melhor estratégia terapêutica.
Cavernomas pontinos extraventriculares. Parte II. Acesso pré-sigmoideo transpetroso a cavernoma pontino ventrolateral
Authors: Stávale Joaquim Marcos Augusto , Patriota Gustavo Cartaxo , Bianco André de Macedo 
Published: January 2018

Resumo
Objetivo: Descrever a via pré-sigmoidea ampliada para acesso a lesões localizadas na região ventrolateral da ponte, exemplificado com a apresentação de um caso de cavernoma pontino nessa localização. Conclusão: Esse acesso, amplamente revisto pela literatura, é útil para remoção cirúrgica de cavernomas pontinos ventrolaterais.