bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large scale structure-aware pronoun resolution using quantum natural language processing
Authors: Wazni Hadi , Lo Kin Ian , McPheat Lachlan , Sadrzadeh Mehrnoosh 
Published: September 2024

AbstractNatural language consists of words, sentences, and larger units. Guided by grammatical structure, words compose with each other to form sentences. Similarly, guided by discourse structure, sentences compose with each other to form dialogues and documents. Classical machine learning algorithms have achieved significant success in learning the meanings of words. When it comes to meanings of sentences and discourse units, they however fall short of being compositional. The DisCoCat model of meaning, introduced by Clark, Coecke, and Sadrzadeh in 2010, provides a solution—at the sentence level—using higher-order tensors, the learning of which has been a challenge. A recent initiative known as Quantum Natural Language Processing (QNLP) introduces a translation between the DisCoCat tensors and Variational Quantum Circuits (VQC). This offers the potential of learning these higher-order tensors more efficiently when the circuits are executed on quantum computers. In previous work, we lifted the DisCoCat framework from the sentence level to the discourse level using a Fock space semantics. In this paper, we extend the DisCoCat-VQC translation to this semantics and experiment with it in a discourse task. We develop a massive dataset with 16,400 entries inspired by a major coreference resolution task, known as the Winograd Schema Challenge, proposed as a test of machine intelligence. Noisy and noiseless simulations were executed on IBMQ software, and the parameters of the discourse VQCs were learnt. The model converged to 77.5% accuracy, surpassing a Bag-of-Words model that neglects any structure. It also outperformed 2 out of 3 state-of-the-art classical coreference resolution architectures. These findings highlight the significant potential of quantum machine learning in advancing discourse analysis and structured natural language processing.
Capturing MRSA Diversity by Integrating Genomic and Epidemiological Data of Patients and their Spaces
Authors: Clement Tasmine , Panson Kristen , Cassone Marco , Mohammed Pirani Ali , Snitkin Evan , Mody Lona 
Published: September 2024

Background: Methicillin-resistant S. aureus (MRSA) is known to cause frequent and severe infections in community living centers, potentially resulting in significant mortality for elderly patients. More research is needed to understand how to utilize genomic and epidemiological data to understand characteristics that may lead to increased transmission. We hypothesized that combining genomic and epidemiological information to sample patients and their environments during long-term stays, we will be able to capture a diverse set of MRSA strains. Method: This work included genome sequencing of patient and environmental samples from 11 patients within the VA Ann Arbor Healthcare System from May 4, 2021- November 16, 2022. All 11 patients tested positive for MRSA during their stay (mean days = 31). Patient and environmental samples were taken throughout their stays, screened for MRSA, and whole-genome sequenced. Single nucleotide variants (SNVs) were identified by mapping reads and calling variants against strain-specific reference genomes. We used ape v5.6-2 in R v4.2.2 to analyze and infer evolution, acquisition, and transmission events based on pairwise SNV distances. Genomic clusters were determined using stats v3.6.2, with a SNV distance threshold of 20. Result: Samples that were collected from patient bodily sites were able to reveal 20 distinct genomic clusters of MRSA (patient hands: n = 10, nares: n = 7, groin: n = 3). Environmental samples from patient environments also revealed distinct genomic MRSA clusters (tv remote: n = 9, toilet seat and bed rail: n = 6, table top, bed control, and call button: n = 5, bed curtain: n = 4, pulse ox = 2, cell phone, tray, pulse ox, mat, body hoist wrap, and bed: n = 1). Conclusion: The identification of various genomic clusters from patients and their environmental reservoirs suggests intrahost variation that can only be captured by using a more holistic approach of integrating epidemiology and genomic sequencing. Developing studies that incorporate genomic data, various environmental sources, and multiple isolates over time within community living centers can increase our understanding of strains that are more likely to transmit, survive on living and non-living surfaces and therefore lead to improved recommendation for infection prevention interventions and drivers of endemicity.Disclosure: Lona Mody: NIH, VA, CDC, Kahn Foundation; Honoraria: UpToDate; Contracted Research: Nano-Vibronix
Timing Is Everything: Recognizing the Importance of Infusion Duration in Preoperative Antimicrobial Prophylaxis
Authors: Oakes Peter , Donohue Lindsay , Chiao Sunny , Ketcham Susan , Terenyi James , Hedrick Traci , Mathers Amy 
Published: September 2024

Background: For preoperative antimicrobials to be most effective in preventing surgical site infection, they must be administered early enough to reach a minimum tissue concentration that is specific to each drug. However, antibiotics have widely ranging infusion durations, from intravenous push over a few minutes to slow infusion over two hours. Heterogeneity in recommended infusion administration instructions, importance of infusion completion prior to incision, and complexity of healthcare systems present just some of the barriers to achieving appropriate preoperative antibiotic prophylaxis. We compared the percentage of infusion completion prior to case start before and after a multidisciplinary intervention. Methods: We performed a retrospective analysis of all patients undergoing a colorectal surgical procedure as defined by the National Healthcare Safety Network at a single university hospital from 10/19/22-10/18/23. A recognition that some antimicrobials were not finished infusing prior to surgery start prompted a multidisciplinary group including antibiotic stewardship, colorectal surgery, perioperative nursing, and anesthesiology to create and deploy an order set shortening metronidazole infusion duration from 60 to 30 minutes and initiating infusion in the preoperative area instead of the operating room. No change to the cefazolin intravenous push over 3-5 minutes was made. Goal antimicrobial infusion was defined as completed infusion within 120 minutes prior to incision, and calculations were made based on infusion start time and case start times. Rate of infusion completion was compared from the pre-intervention period to a post-intervention period from 10/19/23 through the end of the year. Results: For all colorectal surgeries in the pre-intervention period, 95% (n=418/440) of cefazolin doses and 0.002% (n=1/427) doses of metronidazole met goal infusion timing. At-goal infusion timing increased to 99% (n=84/85) of cefazolin doses and 68% (n=56/82) of metronidazole doses in the post-intervention period, resulting in a statistically significant improvement for metronidazole (Fischer’s exact test p < 0 .00001). The average time to metronidazole infusion completion changed from 45 minutes after procedure start to 58 minutes before procedure start. Conclusions: Multidisciplinary team engagement and deployment of an order set incorporating changes in duration and workflow for metronidazole infusion improved all antimicrobial preoperative infusions for colorectal procedures. Increased awareness of completing antimicrobial infusion prior to the incision may improve preoperative antimicrobial administration.Disclosure: Lindsay Donohue: Advisor - Abbvie
Survey of Hemodialysis Patients’ Knowledge of Their Infection Risk and Acceptability of a Nasal Decolonization Intervention
Authors: Armstrong-Pavlik Fiona , Racila AM , Ward Melissa , Tolomeo Pam , Kellogg Joseph , Lindsey Brenna , Herwaldt Loreen , Nair Rajeshwari , Jacob Jesse , Vijayan Anitha , Pegues David , Cobb Jason , Fraer Mony , Bleasdale Susan , Dukes Kimberly , Hockett Sherlock Stacey , Schweizer Marin 
Published: September 2024

Background: Patients undergoing hemodialysis are at high risk for healthcare-associated infections; they are at 100 times the risk of Staphylococcus aureus bloodstream infections (BSI) compared with U.S. adults not on hemodialysis. Prior studies found that nasal decolonization with mupirocin prevented S. aureus BSI among hemodialysis patients. We implemented a nasal decolonization intervention in which patients self-administered povidone-iodine (PVI) at each dialysis session. We aimed to assess: 1) hemodialysis patients’ knowledge of their infection risk and their willingness to take an active role in infection prevention; 2) the acceptability of the PVI nasal decolonization intervention. Methods: We performed a stepped wedge cluster randomized trial at 16 outpatient hemodialysis centers. Patients were surveyed: before starting PVI, 1 month after their center started using PVI, and ~6 months after starting PVI. We used a chi-square test to compare results. Results: 469 patients completed at least 1 survey: 400 pre-intervention, 237 at 1 month and 201 at 6 months. Overall, 56% of patients thought that their risk of infection was average or below average compared with an average person in the U.S. (Figure). Over 98% agreed with the statement “One of the most important things I can do for my health is to take an active role in my health care." In the pre-intervention survey, 73% were willing to do “a lot of effort” to prevent an infection. This proportion was similar (73%) in the 2nd survey, but decreased to 63% in the final survey (p < 0 .01). Among 106 patients who reported starting PVI, 85% reported that PVI felt neutral or pleasant, 9.4% reported a side effect, and 79% reported using it during the past 3 dialysis sessions. Among 102 patients who reported using PVI at 6 months, 87% said it felt neutral/pleasant, 3.9% reported a side effect and 75% reported using it during the past 3 dialysis sessions. Side effects included nasal dripping, congestion or burning/stinging, unpleasant smell, headache, yellow tears, and minor nose bleeding. Conclusions: Hemodialysis patients are not aware of their high risk of infection. Although many were willing to expend a lot of effort to prevent an infection, this willingness decreased during an infection prevention intervention. There were few PVI side effects and most patients stated that PVI felt neutral/pleasant, yet many patients chose to not use PVI. Future research should aim to improve patient education on their risk of infection and assess barriers to adherence with infection prevention interventions.Disclosure: Marin Schweizer: Speaker- 3M; Contracted research-3M; Anitha Vijayan: Honoraria - Quanta, Baxter, Fresenius Consulting, Astute, NxStage
A Deeper Look at Proposed Surveillance of Superficial Incision Surgical Site Infections (SSISSIs)
Authors: Seidelman Jessica , Wood Brittain , Padgette Polly , Payne Valerie , Crane Linda , Roach Linda , Anderson Deverick 
Published: September 2024

Although the National Healthcare Safety Network (NHSN) recommends the reporting of superficial incisional SSIs, the standardized infection ratio (SIR) models used by the NSHN exclude superficial incisional SSIs cases. Yet, some superficial incisional SSIs may lead to serious adverse patient outcomes. We previously proposed a new category of such infections: serious superficial incisional surgical site infections (SSISSIs), defined as a superficial incisional SSI that (1) required debridement in an operating room and/or (2) led to a hospital readmission within 30 days of surgery. The objective of our study was to determine the prevalence of SSISSIs in a large network of community hospitals and compare hospital rankings of SSI rates of organ/space and deep SSIs (complex SSIs) with and without SSISSIs. We performed a retrospective descriptive analysis of prospectively collected data on 35 NHSN surgical categories in 47 community hospitals within the Duke Infection Control Outreach Network (DICON) from 1/1/2013-12/31/2022. All hospitals used standardized surveillance and data collection strategies throughout the study period. The Wilcoxon rank-sum was used to test for differences in performance rankings of hospitals sorted by rates of complex SSIs alone compared to complex and SSISSI rates. A two-tailed P value of .05 or less was considered significant. Overall, 11,617 SSIs occurred after 1,272,257 surgeries (0.91 SSIs/100 procedures). Out of 3,996 superficial SSIs, 2,038 (17.5% overall, 51.0% of superficial incisional) met criteria for SSISSI. 112 (5.5%) were diagnosed during the current admission and required takeback to the OR for infection; 1,926 (94.5%) were diagnosed during a readmission; and 3841 (33.1%) were diagnosed during readmission and returned to the OR. (Table1) The highest proportion of SSISSIs was diagnosed in patients who underwent gastrointestinal surgery (32.0%) or orthopedic surgery (24.0%). (Table2) Performance ranking of individual hospitals based on rates of complex SSIs, differed significantly when including SSISSIs (p= 0.02). (Table3) Discussion Our findings suggest that SSISSIs make up a moderate but important proportion of SSIs in community hospitals. SSISSIs can be identified through established database surveillance looking at objective measures of returning to the OR for debridement and/or readmission within 30 days. Hospital rankings differed significantly when SSISSIs were added to complex SSIs to calculate SSI rates. As such, including SSISSIs likely provides a more accurate depiction of SSIs with important outcomes and is not as subjective to surveillance bias. Next steps would be specifically to look at outcomes data for complex SSIs compared to SSISSIs to fully evaluate theDisclosure: Jessica Seidelman: UptoDate- Section Editor; BoneSupport- Consultant
“AWECoP has made my teaching experience so much better!” – Creating community and improving teaching practice through an Animal Welfare Education Community of Practice (AWECoP)
Authors: Ventura Beth A , Proudfoot Kathryn 
Published: September 2024

Abstract
An animal welfare education community of practice (AWECoP) for those teaching animal welfare science, applied ethology, and/or animal ethics was created to develop a dialogue amongst educators within the field of animal welfare science. The purpose of this paper is to describe the history, objectives, and members’ experiences within this community. AWECoP hosts 6–8 meetings annually for members to discuss topics relevant to our community and exchange teaching resources; within its first two years, the community has grown to 121 members representing approximately 70 institutions across six continents. A 12-question, mixed-method survey was distributed to capture member demographics, engagement with AWECoP, motivations for joining, and self-evaluation of AWECoP’s impacts. Quantitative data from the survey are presented descriptively, while reflexive thematic analysis was applied to the qualitative data. Survey respondents (n = 54) felt that AWECoP is a vital community and safe space for members to share their ideas and receive feedback, inspiration, information, and resources regarding subject-specific and broader pedagogical topics. As a result, a majority experienced professional (e.g. development of new contacts) and personal (e.g. increased feeling of belonging in their field) benefits, as well as impacts realised in their teaching practice. We conclude with an examination of challenges faced in ensuring AWECoP remains accessible to a growing membership and offer recommendations for facilitating similar communities to support fellowship and training in the teaching of animal welfare and related disciplines.
A comparison of the welfare of free-ranging native pony herds on common land with those used for conservation grazing in the UK
Authors: McDonald Sophia , Harley Jessica J , Hockenhull Jo 
Published: September 2024

Abstract
Free-ranging native Dartmoor and Exmoor ponies have not only held strong cultural and environmental significance for thousands of years within their respective national parks, but their environmental benefits and naturally selected characteristics have also been acknowledged and harnessed for conservation grazing and rewilding programmes. Despite a wealth of literature regarding the welfare of sports, leisure and working horses, there is little information concerning the welfare of free-ranging and extensively grazing ponies. The present study compared the welfare of native Exmoor and Dartmoor ponies grazing on the moors in their respective national parks (n = 47) with those that have been translocated to other areas of the UK for use in conservation grazing and rewilding programmes (n = 29) using a specifically designed observational welfare assessment protocol for free-ranging ponies. The results showed a significant difference between common land and conservation grazing ponies in the scores for Body Condition Score, Water Quality and Availability, Environmental Hazards, Human Disturbance, Skin and Coat Condition and the Human Approach Test. Despite no evidence of significant welfare compromise being identified, this study emphasises the importance of year-round monitoring of welfare and the feasibility of the observational welfare protocol to be used by pony keepers and grazing managers in the future.
Impact of an enterprise-wide ambulatory antibiotic stewardship bundle on patient satisfaction surveys
Authors: Jensen Kelsey L. , Stevens Ryan W. , Vergidis Paschalis , Virk Abinash , Ilges Dan 
Published: September 2024

AbstractAn association between antibiotic prescribing in upper respiratory infection and improved patient satisfaction has been documented, though data are mixed. Following implementation of a multifaceted antimicrobial stewardship bundle, no difference in patient satisfaction was observed between groups, despite a reduction in antibiotic prescribing from 28.3% to 14.1%.
Estimating public opinion from surveys: the impact of including a “don't know” response option in policy preference questions
Authors: Elkjær Mads Andreas , Wlezien Christopher 
Published: September 2024

Abstract
What are the consequences of including a “don't know” (DK) response option to attitudinal survey questions? Existing research, based on traditional survey modes, argues that it reduces the effective sample size without improving the quality of responses. We contend that it can have important effects not only on estimates of aggregate public opinion, but also on estimates of opinion differences between subgroups of the population who have different levels of political information. Through a pre-registered online survey experiment conducted in the United States, we find that the DK response option has consequences for opinion estimates in the present day, where most organizations rely on online panels, but mainly for respondents with low levels of political information and on low salience issues. These findings imply that the exclusion of a DK option can matter, with implications for assessments of preference differences and our understanding of their impacts on politics and policy.
Exposure to anti-refugee hate crimes and support for refugees in Germany
Authors: Kuhn Eroll , Maxwell Rahsaan 
Published: September 2024

Abstract
In recent years, anti-refugee hate crimes have soared across Europe. We know this violence has spread fear among refugees, but we know less about its effects on the non-refugee population. This is an oversight, as research suggests political violence often has effects on the broader population. Those effects can range from increased solidarity with the targets of the violence to reduced pro-social behavior and less support for the targets of the violence. In this research note, we examine the effects of exposure to anti-refugee hate crimes in Germany. Our results suggest no direct effect of exposure to anti-refugee hate crimes on support for refugees. These results have several implications for our understanding of political divides over refugees in Europe.
Geometry of milk liners affects milking performance in dairy cows
Authors: Herath H. M Gayani P. , Kudrass Dino , Bryant Racheal H. , Al-Marashdeh Omar 
Published: September 2024

AbstractThe geometry of milk liners may affect milking performance and cow comfort as the milk liner is the only part of the milking machine that comes into contact with the teat. To determine the effect of alternative shape of milk liners we compared square (SQR) vs. the conventional round (RND) teat cup liner on milking performance and comfort of dairy cows. Treatment milk liners were randomly allocated to clusters within each side of the 12 a side double up-herringbone dairy shed in a complete randomised block design over two periods. Milking performance data from a total of 10 065 (late stage of lactation and once-a-day milking frequency, LATE) and 18 048 (early stage of lactation and twice-a-day milking frequency, EARLY) milking events were automatically recorded by a DeLaval milk meter, and separately analysed for LATE and EARLY, respectively. In EARLY, cow comfort behaviour was also recorded during afternoon milking sessions. Across the two study periods, average milk flow rate, milk flow rate during 0–15, 15–30 and 30–60 s after cluster attachment, and milk flow rate at cluster take-off were higher in SQR compared to RND treatment. Proportion of time in a milking session with low milk flow rate and duration of milking session were less in SQR compared to RND treatment. However, effect of geometry of milk liner on peak milk flow rate was inconsistent across the two-study periods. Peak milk flow rate was higher (P < 0.001) in SQR than RND in LATE, but higher (P < 0.001) in RND than SQR in EARLY. Stomping and kicking behaviours of cows were similar between treatments. Results of this study suggest that square milk liners potentially improve milking performance, without adverse effect on cow comfort compared to conventional round liners. Long-term, multi-site studies are required to confirm potential teat-end health benefits associated with square milk liners and further verify these results.