bluuebunny/crossref_metadata_2025_split huggingface dataset:
A narrative review of the associations between six bioactive components in breast milk and infant adiposity
Authors: Fields David A. , Schneider Camille R. , Pavela Gregory 
Published: May 2016

ObjectiveThis narrative review examines six important non‐nutritive substances in breast milk, many of which were thought to have little to no biological significance. The overall objective is to provide background on key bioactive factors in breast milk believed to have an effect on infant outcomes (growth and body composition).MethodsThe evidence for the effects of the following six bioactive compounds in breast milk on infant growth outcomes are reviewed: insulin, leptin, adiponectin, ghrelin, interleukin‐6, and tumor necrosis factor‐α.ResultsThe existing literature on the effects of breast milk insulin, ghrelin, interleukin‐6, and tumor necrosis factor‐α and their associations with infant growth and adiposity is sparse. Of the bioactive compounds reviewed, leptin and adiponectin are the most researched. Data reveal that breast milk adiponectin has negative associations with growth in infancy.ConclusionsThere is a need for innovative, well‐designed studies to improve causal inference and advance our understanding in the effects of breast milk and its components on offspring growth and body composition. The recommendations provided, along with careful consideration of both known and unknown factors that affect breast milk composition, will help improve, standardize, and ultimately advance this emergent field.
Reading for Life and Adolescent Re‐Arrest: Evaluating a Unique Juvenile Diversion Program
Authors: Seroczynski A. D. , Evans William N. , Jobst Amy D. , Horvath Luke , Carozza Giuliana 
Published: May 2016

AbstractWe present results of an evaluation of Reading for Life (RFL), a diversion program for nonviolent juvenile offenders in a medium‐sized Midwestern county. The unique program uses philosophical virtue theory, works of literature, and small mentoring groups to foster moral development in juvenile offenders. Participants were randomly assigned to RFL treatment or a comparison program of community service. The RFL program generated large and statistically significant drops in future arrests. The program was particularly successful at reducing the recidivism of more serious offenses and for those groups with the highest propensity for future offenses.
Incorporation of different conjugated linkers into low band gap polymers based on 5,6‐Bis(octyloxy)‐2,1,3 benzooxadiazole for tuning optoelectronic properties
Authors: Goker Seza , Hizalan Gonul , Kutkan Seda , Arslan Udum Yasemin , Cirpan Ali , Toppare Levent 
Published: May 2016

ABSTRACTFour new 2,1,3‐benzooxadiazole‐based donor–acceptor conjugated polymers, namely poly{9‐(9‐heptadecanyl)‐9H‐carbazole‐alt‐5,6‐bis(octyloxy)‐4,7‐di(selenophen‐2‐yl)benzo[c][1,2,5]oxadiazole)}(PSBSC), poly{9‐(9‐heptadecanyl)‐9H‐carbazole‐alt‐5,6‐bis(octyloxy)‐4,7‐di(furan‐2‐yl)benzo[c][1,2,5]oxadiazole)}(PFBFC), poly{9,9‐dioctyl‐9H‐fluorene‐alt‐5,6‐bis(octyloxy)‐4,7‐di(selenophen‐2‐yl)benzo[c][1,2,5]oxadiazole)}(PSBSFL), and poly{9,9‐dioctyl‐9H‐fluorene‐alt‐5,6‐bis(octyloxy)‐4,7‐di(furan‐2‐yl)benzo[c][1,2,5]oxadiazole)}(PFBFFL), were synthesized via Stille polycondensation reaction. All polymers were found to be soluble in common organic solvents such as chloroform, tetrahydrofuran, and chlorobenzene. Their structures were verified by 1H‐NMR and the molecular weights were determined by gel permeation chromatography (GPC). The polymer films exhibited broad absorption bands. Among all polymers, photovoltaic cells based on the device structure of ITO/PEDOT:PSS/PSBSC:PC71BM(1:3, w/w)/LiF/Al revealed an open‐circuit voltage of 0.62 V, a short circuit current of 7.63 mA cm−2 and a power conversion efficiency of 1.89%. This work demonstrates a good example for tuning absorption range, energy level, and photovoltaic properties of the polymers with different spacers and donor units can offer a simple and effective method to improve the efficiency of PSCs. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 2459–2467
Academic Language in Early Childhood Classrooms
Authors: Barnes Erica M. , Grifenhagen Jill F. , Dickinson David K. 
Published: May 2016

AbstractThis article defines academic language by examining the central features of vocabulary, syntax, and discourse function. Examples of each feature are provided, as well as methods of identifying them in oral language and printed text. We describe a yearlong study that found teachers used different types of academic language based on instructional context. Using the results from this study, we present ideas for noticing and teaching academic language through different instructional settings in early childhood classrooms.
Recruitment of breast cancer survivors and their caregivers: implications for dyad research and practice
Authors: Bazzi Angela Robertson , Clark Melissa A , Winter Michael , Tripodis Yorghos , Boehmer Ulrike 
Published: May 2016

Abstract
Breast cancer survivors' informal caregivers experience adverse health outcomes and could benefit from interventions. Studies of caregivers' participation in research, to date, have assumed heterosexuality. The aim of this study is to identify factors associated with caregiver participation among survivors with diversity in sexual orientation. We recruited breast cancer survivors into a telephone survey and asked them to invite a caregiver. Logistic regression identified factors associated with caregivers' participation. Among 297 survivors, 12 (4 %) had no caregivers, 82 (28 %) refused to provide caregiver information, 203 (68 %) provided caregiver contact, and 167 (56 %) had caregivers participate. Caregiver participation was more likely among sexual minority than heterosexual survivors (aOR: 1.89; 95 % CI: 1.08, 3.32), dyads with higher cohesion, and among caregivers who were partners. Caregiver participation was less likely among survivors with lower education and higher comorbidity. Findings provide insight into recruitment of diverse dyads into cancer survivorship research that will ultimately inform intervention design.
The formation of the Eurasian Economic Union: How successful is the Russian regional hegemony?
Authors: Kirkham Ksenia 
Published: May 2016

January 2015 witnessed an important step towards further integration in Eurasia, with the Eurasian Economic Union (EAEU) coming into operation. It comprises three members of the former Eurasian Customs Union (CU), Russia, Belarus and Kazakhstan, plus Kyrgyzstan and Armenia. Recent debates on Eurasian integration consider the EAEU to be a Russian hegemonic project in the region. However, the potential of this project is yet to be discovered. This article has pioneered in applying the neo-Gramscian approach to analysing the potential for the EAEU as a Russian counter-hegemonic initiative. The neo-Gramscian understanding of hegemony, which constitutes of four core elements, is reflected in the structure of the article: the institutional design, material capabilities (the capitalist system), security invulnerability (geopolitics) and cultural leadership. The article concludes that Russian regional hegemony has not yet been formed, but has the potential to be completed. Hegemony has been consolidated domestically, and has started outward expansion through the EAEU as its institutional mechanism. However, to succeed with its hegemonic project, the Russian government should not simply copy the EU's institutional design but learn how to present the achievements of integration as successful efforts at creating a strong welfare system that favours key social groups in order to obtain social consent and take cultural leadership. The novelty of the presentation of hegemony as an evolutionary process, which passes through initial, transitional and conclusive phases of its development, along with the recentness of the EAEU as a topic, could make this article a contribution to Eurasian integration studies.
Life‐course blood pressure in relation to brain volumes
Authors: Power Melinda C. , Schneider Andrea L.C. , Wruck Lisa , Griswold Michael , Coker Laura H. , Alonso Alvaro , Jack Clifford R. , Knopman David , Mosley Thomas H. , Gottesman Rebecca F. 
Published: May 2016

AbstractIntroductionThe impact of blood pressure on brain volumes may be time‐dependent or pattern‐dependent.MethodsOf 1678 participants from the Atherosclerosis Risk in Communities Neurocognitive Study, we quantified the association between measures and patterns of blood pressure over three time points (∼24 or ∼15 years prior and concurrent with neuroimaging) with late life brain volumes.ResultsHigher diastolic blood pressure ∼24 years prior, higher systolic and pulse pressure ∼15 years prior, and consistently elevated or rising systolic blood pressure from ∼15 years prior to concurrent with neuroimaging, but not blood pressures measured concurrent with neuroimaging, were associated with smaller volumes. The pattern of hypertension ∼15 years prior and hypotension concurrent with neuroimaging was associated with smaller volumes in regions preferentially affected by Alzheimer's disease (e.g., hippocampus: −0.27 standard units, 95% CI: −0.51, −0.03).DiscussionHypertension 15 to 24 years prior is relevant to current brain volumes. Hypertension followed by hypotension appears particularly detrimental.
Impact of catheter ablation of ventricular tachycardia in patients with prior myocardial infarctions
Authors: Fukunaga Masato , Goya Masahiko , Hiroshima Kenichi , Hayashi Kentaro , Ohe Masatsugu , Makihara Yu , Nagashima Michio , An Yoshimori , Shirai Shinichi , Ando Kenji , Yokoi Hiroyoshi , Iwabuchi Masashi 
Published: May 2016

AbstractBackgroundCatheter ablation can reduce episodes of ventricular tachycardia (VT) after myocardial infarction (MI). However, the optimal endpoint of the ablation procedure remains unclear.MethodsFifty‐one consecutive patients who received catheter ablation for VT after MI were included. The procedures targeted the isthmus of all the induced, sustained VTs. When the patients with induced VTs were hemodynamically stable, radiofrequency energy was delivered at the mid‐diastolic potential recording site during VT. When the patients with VTs were hemodynamically unstable, the critical channel was identified at the delayed potential recording site, showing a good pace map, with a long stimulus‐QRS interval. We delivered radiofrequency energy along the identified isthmus and across the exit of the circuit.ResultsAt the end of the procedure, all VTs became non‐inducible in 30 patients (59%) and some VTs were inducible in 21 patients (41%). During a mean of 40±29 months of follow‐up, no VT or ventricular fibrillation recurred in 24 patients (80%) in the non‐inducible group and in 12 patients (57%) in the inducible group, respectively (P=0.03). The identification of the channel during VT mapping tended to associate with no recurrence, although the difference was not statistically significant (P=0.2). Fourteen patients (27%) died during the follow‐up period, mostly due to non‐cardiac causes.ConclusionsThe catheter ablation targeting the isthmus of prior‐MIVT and non‐inducibility at the end of the procedure can provide a satisfactory follow‐up result.
Gene expression profiling of single circulating tumor cells in ovarian cancer – Establishment of a multi‐marker gene panel
Authors: Blassl Christina , Kuhlmann Jan Dominik , Webers Alessandra , Wimberger Pauline , Fehm Tanja , Neubauer Hans 
Published: May 2016

The presence of circulating tumor cells (CTCs) in the blood of ovarian cancer patients was shown to correlate with decreased overall survival, whereby CTCs with epithelial–mesenchymal‐transition (EMT) or stem‐like traits are supposed to be involved in metastatic progression and recurrence. Thus, investigating the transcriptional profiles of CTCs might help to identify therapy resistant tumor cells and to overcome treatment failure. For this purpose, we established a multi‐marker panel for the molecular characterization of single CTCs, detecting epithelial (EpCAM, Muc‐1, CK5/7), EMT (N‐cadherin, Vimentin, Snai1/2, CD117, CD146, CD49f) and stem cell (CD44, ALDH1A1, Nanog, SOX2, Notch1/4, Oct4, Lin28) associated transcripts.First primer specificity and PCR‐performance of the multiplex‐RT‐PCRs were successfully validated on genomic DNA and cDNA isolated from OvCar3 cells. The assay sensitivity of the epithelial panel was evaluated by adding defined numbers of tumor cells into the blood of healthy donors and performing a subsequent immunomagnetic tumor cell enrichment (AdnaTest OvarianCancerSelect), resulting in a 100% concordance for the epithelial markers EpCAM and Muc‐1 to the AdnaTest OvarianCancerDetect. Additionally, by processing blood from ovarian cancer patients, high assay sensitivity could be verified. In blood of healthy donors no signals for epithelial markers were detected, for EMT and stem cell markers, however, signals were obtained mainly originating from leukocytes which calls for single cell analysis.To that aim by using the ovarian cancer cell line OvCar3, we successfully established a workflow enabling the characterization of single CTCs. It consists of a density gradient‐dependent enrichment for nucleated cells, a depletion of CD45‐positive cells of hematopoietic origin followed by immunofluorescent labeling of CTCs by EpCAM and Muc‐1. Single CTCs are then isolated by micromanipulation and processed for panel gene expression profiling. Finally, fifteen single CTCs from three ovarian cancer patients were analyzed and found to be positive for stem cell (CD44, ALDH1A1, Nanog, Oct4) and EMT markers (N‐cadherin, Vimentin, Snai2, CD117, CD146). Albeit, inter‐cellular and intra/inter‐patient heterogeneity and co‐expression of epithelial, mesenchymal and stem cell transcripts on the same CTC was observed.We have established a robust workflow to perform sensitive single cell panel gene expression analysis without the need of pre‐amplification steps. Our data point towards a heterogeneous expression of stem cell and EMT associated transcripts in ovarian cancer CTCs.
Body Positioning of Buried Avalanche Victims
Authors: Kornhall Daniel K. , Logan Spencer , Dolven Thomas 
Published: May 2016

Objective The immediate medical management of buried avalanche victims will to some extent be dictated by the victim’s body positioning in the snow. Medical personnel are trained to assess and manage victims in a supine body position. Furthermore, avalanche first responders are trained to handle extricated avalanche victims carefully out of concerns for causing hemodynamic instability or for aggravating spinal injury. Thus, locating and extricating avalanche victims in positions other than supine has the potential to complicate immediate medical management. To our knowledge, the current medical literature does not detail the body positioning of buried victims. Methods In order to ascertain the most common body positioning of buried avalanche victims we reviewed the avalanche incident database of the Colorado Avalanche Information Center (CAIC). This comprehensive database strives to track over 160 fields of information for each avalanche victim, including the body and head positioning of buried victims. Results Head positioning was recorded for 159 buried victims. We found that 65% of buried avalanche victims were found with their heads in a downhill position, 23% with their heads uphill and 11% with their heads in the same level as the rest of their bodies. Body positioning was recorded in 253 victims. 45% of victims were found lying prone, 24% supine, 16% were sitting or standing and 15% were found lying on their sides. We identified 135 victims where both head and body position was registered. 40% of victims were found prone with their heads in a downhill position Conclusions The majority of victims will be extricated with their heads in a downhill position. Moreover, almost half of victims will be found prone. We believe this will have significant impact on the immediate medical management. We believe current training in avalanche medical rescue should emphasize managing victims in non-supine positions. Finally, our findings may represent another benefit of modern extrication techniques.
A multifactorial regression analysis of the features of community-acquired rotavirus requiring hospitalization in Spain as represented in the Minimum Basic Data Set
Authors: REDONDO-GONZÁLEZ O. , TENÍAS-BURILLO J. M. 
Published: May 2016

SUMMARYOver 10% of acute rotavirus gastroenteritis (ARGE) requires hospitalization because of complications. The aggravating factors have been widely analysed, but in an isolated way. We aimed to explore the interrelationship between the clinical and epidemiological factors that characterize rotavirus hospitalizations in Spain using information from the Minimum Basic Data Set (MBDS). Using ICD-9-CM codes, we classified acute gastroenteritis (AGE) cases by principal diagnosis fields and then categorized their comorbidities, complications, and epidemiological features by secondary fields. A multivariable, logistic, step-wise regression model was then constructed. We identified 1657 ARGE cases from 17 415 cases of AGE. Rotavirus hospitalizations were associated with place of residence, age, and season (P < 0·0001), as well as with dehydration [odds ratio (OR) 12·44, 95% confidence interval (CI) 1·52–40·38], intravenous rehydration (OR 1·74, 95% CI 1·29–2·35), metabolic acidosis (OR 1·51, 95% CI 1·24–1·83), respiratory tract infections (RTIs) (OR 1·60, 95% CI 1·09–1·98), and concomitant AGE (OR 1·52, 95% CI 1·03–2·25). Dehydration was four times more likely in patients aged <5 years (OR 4·36, 95% CI 1·20–12·96) and was associated with acidosis when ARGE and RTI were present simultaneously (P < 0·0001). Specific co-infecting viruses may play a role in acute respiratory symptoms and aggravation of gastrointestinal manifestations of rotaviruses, thus leading to complications requiring hospitalization.
Unusual coastal flood impacts in Salmon Valley, McMurdo Sound, Antarctica
Authors: Dayton Paul K. , Hammerstrom Kamille , Jarrell Shannon C. , Kim Stacy , Nordhausen Walter , Osborne D.J. , Thrush Simon F. 
Published: May 2016

AbstractLarge floods bringing significant sediments into the coastal oceans have not been observed in Antarctica. We report evidence of a large flood event depositing over 50 cm of sediment onto the nearshore benthic habitat at Salmon Bay, Antarctica, between 1990 and 2010. Besides direct observations of the sedimentation, the evidence involves a debris flow covering old tyre tracks from the early 1960s, as well as evidence of a considerable amount of sediment transported onto the Salmon Creek delta. We believe that the flood was sourced from the Salmon Glacier and possibly the smaller Blackwelder Glacier. Such floods will be more common in the future and it is important to better understand their ecological impacts with good monitoring programmes.
Brugada syndrome in the paediatric population: a comprehensive approach to clinical manifestations, diagnosis, and management
Authors: Gonzalez Corcia M. Cecilia , de Asmundis Carlo , Chierchia Gian-Battista , Brugada Pedro 
Published: May 2016

AbstractBrugada syndrome is an inherited arrhythmogenic disorder, characterised by coved-type ST-segment elevation in the right precordial leads, and is associated with increased risk of sudden death. It is genetically and clinically heterogeneous, presenting typically in the fourth or fifth decade of life. The prevalence of Brugada syndrome in the paediatric population is low compared with the adult population. Interestingly, over the last several years, there has been growing evidence in the literature of onset of the disease during childhood. Most of the paediatric cases reported in the literature consist of asymptomatic Brugada syndrome; however, some patients manifest the disease at different regions of the cardiac conduction system at a young age. Early expression of the disease can be affected by multiple factors, including genetic substrate, hormonal changes, and still unknown environmental exposures. The initial manifestation of Brugada syndrome in children can include sinus node dysfunction and atrial arrhythmias. Brugada syndrome can also manifest as ventricular arrhythmias leading to sudden death at an early age. In symptomatic children, performance of the ajmaline test by an experienced team can be safely used as a diagnostic tool to unmask latent Brugada syndrome. Defining indications for an implantable cardioverter defibrillator in children with the diagnosis of Brugada syndrome remains challenging. Given the rarity of the syndrome in children, most paediatric cardiologists will only rarely see a young patient with Brugada syndrome and there is still no universal consensus regarding the optimal management approach. Care should be individualised according to the specific clinical presentation, taking into account the family history, genetic data, and the family’s specific preferences.
Under-diagnosis of mood disorders in Canada
Authors: Pelletier L. , O'Donnell S. , Dykxhoorn J. , McRae L. , Patten S. B. 
Published: May 2016

Aims.Under-diagnosis of mood disorders occurs worldwide. In this study, we characterized and compared Canadians with symptoms compatible with a mood disorder by diagnosis status; and described the associated health impacts, use of health services and perceived need for care.Methods.Respondents to the 2012 Canadian Community Health Survey – Mental Health, a nationally representative sample of Canadians age ≥15 years were assessed for symptoms compatible with mood disorders based on a Canadian adaptation of the World Health Organization Composite International Diagnostic Interview (n= 23 504). Descriptive and multivariate regression analyses were performed.Results.In 2012, an estimated 5.4% (1.5 million) Canadians aged 15 years and older reported symptoms compatible with a mood disorder, of which only half reported having been professionally diagnosed. The undiagnosed individuals were more likely to be younger (mean age: 36.2v. 41.8), to be single (49.5v. 32.7%), to have less than a post-secondary graduation (49.8v. 41.1%) and to have no physical co-morbidities (56.4v. 35.7%), and less likely to be part of the two lower income quintiles (49.6v. 62.7%) compared with those with a previous diagnosis. Upon controlling for all socio-demographic and health characteristics, the associations with age and marital status disappeared. While those with a previous diagnosis reported significantly greater health impacts and were more likely to have consulted a health professional for their emotional and mental health problems in the previous 12 months compared with those undiagnosed (79.4v. 31.0%), about a third of both groups reported that their health care needs were only partially met or not met at all.Conclusions.Mood disorders are prevalent and can profoundly impact the life of those affected, however, their diagnosis remains suboptimal and health care use falls short of apparent needs. Improvements in mental health literacy, help-seeking behaviours and diagnosis are needed. In light of the heterogeneity of mood disorders in terms of symptoms severity, impacts and prognosis, interventions must be tailored accordingly.