bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metachronous Involvement, Diagnostic Imprecision of Serum Immunoglobulin G4 Levels, and Discordance Between Clinical and Radiological Findings in Immunoglobulin G4–Related Pachymeningitis
Authors: Waheed Waqar , Skidd Philip Michael , Borden Neil M. , Gibson Pamela C. , Babi Mohamed Ali , Tandan Rup 
Published: March 2017

Abstract
Immunoglobulin G4–related disease is an increasingly recognized, idiopathic systemic disorder that might be associated with elevated serum IgG4 level and tissue infiltration by IgG4-positive plasma cells. We describe the clinical features and biopsy findings in a patient who presented with features suggestive of pachymeningitis and multiple cranial neuropathies. Meningeal biopsy and other laboratory studies established the diagnosis of IgG4-related hypertrophic pachymeningitis. Despite treatment with corticosteroids and mycophenolate mofetil, the patient exhibited a fluctuating progressive course, which stabilized with rituximab, although the radiological findings persisted over 2½ years of follow-up. Our case highlights many important evolving concepts in the disorder, including unusual pathologic features, lack of correlation between serum IgG4 levels and the clinical course, and posttreatment clinicoradiological discordance. We provide potential explanations for this discrepancy, highlight the validity of novel cerebrospinal fluid studies and progressive systemic involvement despite use of immune-suppressive treatments, and emphasize the usefulness of rituximab as a disease-stabilizing agent.
Anal Penetrative Intercourse as a Risk Factor for Fecal Incontinence
Authors: Geynisman-Tan Julia , Kenton Kimberly , Leader-Cramer Alix , Dave Bhumy , Bochenska Katarzyna , Mueller Margaret , Collins Sarah Abbie , Lewicky-Gaupp Christina 
Published: March 2017

Objective
The aim of the study is to investigate the relationship between anal penetrative intercourse (API) and pelvic floor symptoms, specifically, anal incontinence (AI).

Methods
This was an institutional review board–approved, cross-sectional, e-mail survey of women enrolled in the Illinois Women's Health Registry. Participants were anonymously queried about their sexual practices and the effects of these on bowel and bladder symptoms. Urinary symptoms were assessed using the urogenital distress inventory-6 and bowel symptoms with the fecal incontinence severity index (FISI).

Results
One thousand three women (mean age of 46 ± 15 years) completed the survey. Eighty percent were white, 56% were married, and 99% reported ever being sexually active. Thirty-two percent had API at least once, and 12% considered it “part of their sexual practice.” Sixty percent of the cohort reported a bothersome urinary symptom on the urogenital distress inventory-6, 70% reported AI on the FISI, and 15% reported fecal incontinence. Of women who engaged in API, 18% reported it changed their stool consistency, and 10% reported it caused AI. Having engaged in API within the last month was correlated with higher FISI scores (P = 0.05) and with fecal incontinence on the FISI (28.3% vs 14.4%; P = 0.01; odds ratio, 2.48). In addition, API was more commonly practiced among women who reported that vaginal intercourse caused dyspareunia (17% vs 12%, P = 0.05) or changes in bladder symptoms such as urgency or dysuria (44% vs 30%, P < 0.001).

Conclusions
Self-reported AI and FI (as measured by the FISI scores) are higher in women who have had API, and frequency of API may be important in determining the risk of bowel symptoms.
Extracranial origin of headache
Authors: Burstein Rami , Blake Pamela , Schain Aaron , Perry Carlton 
Published: March 2017

Purpose of reviewTo summarize recent clinical and preclinical studies on extracranial pathophysiologies in migraine. It challenges the opinion-based notion that the headache phase of migraine occurs without input from peripheral nociceptors or is caused solely by activation of intracranial nociceptors supplying dural and cerebral vasculature.Recent findingsData that support a scenario by which migraine can originate extracranially include the perception of imploding headache that hurts outside the cranium, the existence of a network of sensory fibers that bifurcate from parent axons of intracranial meningeal nociceptors and reach extracranial tissues such as periosteum and pericranial muscles by crossing the calvarial bones through the sutures, the discovery of proinflammatory genes that are upregulated and anti-inflammatory genes that are down regulated in extracranial tissue of chronic migraine patients, and evidence that administration of OnabotulinumtoxinA to peripheral tissues outside the calvaria reduces frequency of migraine headache.SummaryThese findings seeks to shift clinical practice from prophylactically treating chronic migraine solely with medications that reduce neuronal excitability to treating irritated nociceptors or affected tissues. The findings also seeks to shift current research from focusing solely on central nervous system alterations and activation of meningeal nociceptors as a prerequisite for studying migraine.
Co-occurrence of migraine and atopy in children and adolescents: myth or a casual relationship?
Authors: Özge Aynur , Uluduz Derya , Bolay Hayrunnisa 
Published: March 2017

Purpose of review
To clarify the causal relationship between migraine and atopic disorders in children and adolescents.

Recent findings
Migraine headache and atopic disorders including asthma are both common functional syndromes of childhood in which nature of the relationship is still debated. Attacks may induce in both disorders upon exposure to potential triggers in genetically susceptible individuals. Clinical phenotype manifests by temporary dysfunction of target tissue mediated by inflammation triggered by specific agents. Clinical features also change after puberty because of the partial effect of female sex hormones on the process. Appropriate definition of the syndrome and differentiating from other disorders are necessary not only for correct diagnosis, but also for planning of management strategies in children. Allergic rhinosinusitis needs to be differentiated from migraine even in experienced clinics. Questioning the presence of cranial autonomic symptoms is important clue in the differential diagnosis. Atopic disorder screening is particularly required in the diagnosis of migraine in childhood and adolescents. The link between both disorders of childhood seems to be far from a coincidence and some common inflammatory mechanisms are shared.

Summary
On the basis of clinical features, laboratory findings and some practical clues in children, accurate diagnosis of migraine and atopic disorders are very critical for physicians, pediatricians and algologists.
Reconstruction of cell lineages and behaviors underlying arthropod limb outgrowth with multi-view light-sheet imaging and tracking
Authors: Wolff Carsten , Tinevez Jean-Yves , Pietzsch Tobias , Stamataki Evangelia , Harich Benjamin , Preibisch Stephan , Shorte Spencer , Keller Philipp J. , Tomancak Pavel , Pavlopoulos Anastasios 
Published: March 2017

SUMMARYDuring development coordinated cell behaviors orchestrate tissue and organ morphogenesis to suit the lifestyle of the organism. We have used here the crustaceanParhyale hawaiensisto study the cellular basis of limb development. TransgenicParhyaleembryos with fluorescently labeled nuclei were imaged at high spatiotemporal resolution with multi-view light-sheet fluorescence microscopy over several days of embryogenesis spanning appendage morphogenesis from early specification up to late differentiation stages. Cell tracking with a new tool called Massive Multi-view Tracker (MaMuT) enabled the reconstruction of the complete cell lineage of an outgrowing thoracic limb with single-cell resolution.In silicoclonal analyses suggested that the limb primordium becomes subdivided from an early stage first into anterior-posterior and then into dorsal-ventral compartments whose boundaries intersect at the distal tip of the growing limb. Limb bud formation is associated with the spatial modulation of cell proliferation, while limb elongation is also driven by the preferential orientation of division of epidermal cells along the proximal-distal axis of growth. Cellular reconstructions were predictive of the expression patterns of limb development genes including the Decapentaplegic (Dpp) morphogen.HIGHLIGHTSMulti-view light-sheet microscopy of crustacean embryos from speciesParhyale hawaiensisare ideal for cellular-level analysis of organ morphogenesis.Lineages of 3-dimensional organs were reconstructed at single-cell resolution with the Fiji/ImageJ plugin Massive Multi-view Tracker.TheParhyalelimb primordium undergoes early lineage restrictions associated with particular cell behaviors and patterns of gene expression.Differential rates of cell proliferation and oriented cell divisions guide appendage proximal-distal outgrowth.
Design and validation of a trust-based opportunity-enabled risk management system
Authors: Aldini Alessandro , Seigneur Jean-Marc , Ballester Lafuente Carlos , Titi Xavier , Guislain Jonathan 
Published: March 2017

Purpose
The Bring-Your-Own-Device (BYOD) paradigm favors the use of personal and public devices and communication means in corporate environments, thus representing a challenge for the traditional security and risk management systems. In this dynamic and heterogeneous setting, the purpose of this paper is to present a methodology called opportunity-enabled risk management (OPPRIM), which supports the decision-making process in access control to remote corporate assets.

Design/methodology/approach
OPPRIM relies on a logic-based risk policy model combining estimations of trust, threats and opportunities. Moreover, it is based on a mobile client – server architecture, where the OPPRIM application running on the user device interacts with the company IT security server to manage every access request to corporate assets.

Findings
As a mandatory requirement in the highly flexible BYOD setting, in the OPPRIM approach, mobile device security risks are identified automatically and dynamically depending on the specific environment in which the access request is issued and on the previous history of events.

Originality/value
The main novelty of the OPPRIM approach is the combined treatment of threats (resp., opportunities) and costs (resp., benefits) in a trust-based setting. The OPPRIM system is validated with respect to an economic perspective: cost-benefit sensitivity analysis is conducted through formal methods using the PRISM model checker and through agent-based simulations using the Anylogic framework.
Cloud computing assurance – a review of literature guidance
Authors: von Solms Rossouw , Willett Melanie 
Published: March 2017

Purpose
This paper aims to provide guidance on cloud computing assurance from an IT governance point of view. The board and executive management are tasked with ensuring proper governance of organizations, which should in the end contribute to a sense of assurance. Assurance is understood to be a part of corporate governance which provides stakeholders with confidence in a subject matter by evaluating evidence about that subject matter. Evidence will include proof that proper controls and structures are in place, that risks are managed and that compliance with internal and external requirements is demonstrated with regard to the subject matter. Decisions regarding the use of cloud computing in organizations bring these responsibilities to the fore.

Design/methodology/approach
The design of this paper is based on an extensive review of literature, predominantly best practices and standards, from the fields covering IT governance, cloud computing and assurance.

Findings
The results from this paper can be used to formulate cloud computing assurance evidence statements, as part of IT governance mandates.

Originality/value
This paper aims to add value by highlighting the responsibility of managers to ensure assurance when exploiting opportunities presented through IT advances, such as cloud computing; serving to inform management about the advances that have and are being made in the field of cloud computing guidelines; and motivating that these guidelines be used for assurance on behalf of organizations adopting and using cloud computing.
The changing IFRS debate in the USA: a rejoinder
Authors: Negash Minga , Holt Andrew , Hathorn John 
Published: March 2017

PurposeThe debate on whether global accounting standards are appropriate for use within the US regulatory environment has not yet ended. Nearly four years after the release of the Securities and Exchange Commission’s (SEC’s) much awaited report on the issue, the position of the regulator is still unclear, and the US accounting community is uncertain about the potential for accounting change. This paper aims to examine the documented reasons for the absence of direction and clarity on this issue.Design/methodology/approachUsing the theoretical and empirical contributions of prior research on International Financial Reporting Standards (IFRS), this study explores the potential for US adoption of IFRS by examining the main arguments forwarded by the Office of the Chief Accountant of the SEC and the International Accounting Standards Board’s response to the issues raised and by capturing the opinions of 22 graduate and 32 undergraduate students as surrogates for future practicing accountants. The student data were collected from homework submissions to an essay on US accounting convergence with IFRS.FindingsFrom the analysis, the authors make four observations. First, the deliberations over IFRS adoption in the USA are not sufficiently grounded on principles of recognition, measurement and disclosure. Second, the evidence does not support the notion that IFRS is of inferior quality to current US generally accepted accounting principles. Third, the problem areas stem from the apparent divergence of the objectives ascribed to financial statements, the independence and public accountability of the global standard setter and standards that are connected with the regulation of the finance and insurance industries. The final observation is the political process of managing change in the standard setting/adoption process in the USA.Originality/valueThis paper provides a comprehensive appraisal and a change management perspective to the ongoing IFRS debate in the USA by soliciting and documenting the opinions of future practicing accountants.
Impact of performance audit on the Administration: a Belgian study (2005-2010)
Authors: Desmedt Ella , Morin Danielle , Pattyn Valérie , Brans Marleen 
Published: March 2017

Purpose
This study of the impact of Belgian Court of Audit on Federal Administration for the 2005 to 2010 period aims to highlight the auditors’ influence on the management of governmental organizations through the performance audits they have been conducting since 1998. A set of ten variables allows us to measure the three types of uses of performance auditors’ work by auditees: instrumental, conceptual and strategic use.

Design/methodology/approach
A survey was sent out to a total of 148 respondents identified by the authorities of the targeted organizations; 47 usable questionnaires were completed (32 per cent response rate).

Findings
The Court of Audit’s impact on the audited entities did not provoke radical changes in the auditees’ organizational life, but the intervention of the auditors was nevertheless noticeable. The nature of the impact was rather conceptual than strategic or instrumental. And the negative consequences on auditees anticipated in the literature were not observed.

Research limitations/implications
Given the five-year period covered by the study which was made in 2014 (four years after 2010), it had to deal with the mortality of respondents and the loss of organizational memory.

Practical implications
The study gives more accurate insights about the influence that Supreme Audit Institutions (SAIs) actually exert on audited Administrations through their performance audits.

Originality/value
Because SAIs have been mandated to evaluate the government’s economy, efficiency and effectiveness for almost 40 years in the Western democracies, it is mandatory that their actual ability to influence Administrations be documented more abundantly and independently by academic researchers.
Impact of predicted precipitation scenarios on multitrophic interactions
Authors: Wade Ruth N. , Karley Alison J. , Johnson Scott N. , Hartley Sue E. 
Published: March 2017

SummaryPredicted changes in the frequency and intensity of extreme rainfall events in theUKhave the potential to disrupt terrestrial ecosystem function. However, responses of different trophic levels to these changes in rainfall patterns, and the underlying mechanisms, are not well‐characterised.This study aimed to investigate how changes in both the quantity and frequency of rainfall events will affect the outcome of interactions between plants, insect herbivores (above‐ and below‐ground) and natural enemies.Hordeum vulgareL. plants were grown in controlled conditions and in the field, and subjected to three precipitation scenarios: ambient (based on a local 10 year average rainfall); continuous drought (40% reduction compared with ambient); drought/deluge (40% reduction compared to ambient at a reduced frequency). The effects of these watering regimes and wireworm (Agriotesspecies) root herbivory on the performance of the plants, aphid herbivores above‐ground (Sitobion avenae, Metapolophium dirhodum, andRhopalosiphum padi), and natural enemies of aphids including ladybirds (Harmonia axyridis) were assessed from measurements of plant growth, insect abundance and mass, and assays of feeding behaviour.Continuous drought decreased plant biomass, whereas reducing the frequency of watering events did not affect plant biomass but did alter plant chemical composition. In controlled conditions, continuous drought ameliorated the negative impact of wireworms on plant biomass.Compared with the ambient treatment, aphid mass was increased by 15% when feeding on plants subjected to drought/deluge; and ladybirds were 66% heavier when feeding on these aphids but this did not affect ladybird prey choice. In field conditions, wireworms feeding below‐ground reduced the number of shoot‐feeding aphids under ambient and continuous drought conditions but not under drought/deluge.Predicted changes in both the frequency and intensity of precipitation events under climate change have the potential to limit plant growth, but reduce wireworm herbivory, whilst simultaneously promoting above‐ground aphid numbers and mass, with these effects transferring to the third trophic level. Understanding the effect of future changes in the precipitation on species interactions is critical for determining their potential impact on ecosystem functioning and constructing accurate predictions under global change scenarios.Alay summaryis available for this article.
Inequality and Growth: Reviewing the Economic and Social Impacts
Authors: Ward Tony 
Published: March 2017

AbstractDoes rising inequality provide incentives for individuals to work harder and invest? Or does it hamper economic growth? This article reviews the now‐extensive literature on the subject. It starts by outlining some of the social impacts of recent increases in inequality, concentrating on those affecting economic growth. It then notes the diverse results from econometric studies. From these results, the article focuses on the mechanisms suggested in the literature linking inequality and economic growth. It summarises results in five broad areas. While specifics vary with circumstances, in most, increases in inequality have negative impacts on economic growth.
A Short Review of the Recent Literature on Uncertainty
Authors: Castelnuovo Efrem , Lim Guay , Pellegrino Giovanni 
Published: March 2017

AbstractThis article summarises the academic contributions presented and discussed during the 2016 edition of the Melbourne Institute Macroeconomic Policy Meetings, which focused on the role played by uncertainty for a number of countries’ business cycle. Considerations on the interaction between uncertainty and financial frictions, the global dimension of uncertainty, uncertainty shocks in times of unconventional monetary policy and the imperfect knowledge that agents have over policy targets are among the discussions entertained in this article. The main insights coming from those papers are connected with the extant literature and directions for future research are offered.
Getting Started with PATSTAT Register
Authors: de Rassenfosse Gaétan , Kracker Martin , Tarasconi Gianluca 
Published: March 2017

AbstractThis article provides a technical introduction to the PATSTAT Register database, which contains bibliographical, procedural and legal status data on patent applications handled by the European Patent Office. It presents eight MySQL queries that cover some of the most relevant aspects of the database for research purposes. It targets academic researchers and practitioners who are familiar with the PATSTAT database and the MySQL language.
Spiritual Coping: A Focus of New Nursing Diagnoses
Authors: Cabaço Sandra Rosado , Caldeira Sílvia , Vieira Margarida , Rodgers Beth 
Published: March 2017

OBJECTIVETo define the antecedents, consequents, and attributes of spiritual coping.METHODSRodgers’ evolutionary model for concept analysis was used to guide an integrative literature review of qualitative research.FINDINGSSix qualitative articles were included and elements that define and contextualize the concept were identified.CONCLUSIONSThree new nursing diagnoses are proposed, based on qualitative findings.IMPLICATIONS FOR PRACTICEThese new diagnoses should be submitted to clinical validation in different cultural and religious backgrounds, but the inclusion in the taxonomy highlights a holistic perspective concerning the spiritual dimension of patients’ responses in life and health transitions, and so, bringing the approach to spirituality into nursing practice.OBJECTIVODefinir os antecedentes, os consequentes e os atributos de coping espiritual.MÉTODOSModelo evolucionário de análise de conceitos de Beth Rodgers baseado numa revisão integrativa de literatura de pesquisa qualitativa.RESULTADOSSeis pesquisas qualitativas foram incluídas e os elementos que definem e contextualizam o conceito foram identificados.CONCLUSÕESSão propostos três novos diagnósticos de enfermagem, baseados na evidência de estudos qualitativos.IMPLICAÇÕES PARA A PRÁTICAEstes novos diagnósticos devem ser submetidos a estudos de validação clínica em diferentes contextos culturais e religiosos, e quando incluídos na taxonomia estarão a enfatizar uma perspectiva holística das respostas dos pacientes relacionada à dimensão espiritual e, assim, promovendo a inclusão da espiritualidade na prática clínica.