bluuebunny/crossref_metadata_2025_split huggingface dataset:
LAPAROSCOPIC TREATMENT OF ENDOMETRIOSIS
Authors: Canis M. , Mage G. , Manhes H. , Pouly J.L. , Wattiez A. , Bruhat M.A. 
Published: November 2017

Adequate management of endometriosis by laparoscopy included 3 steps: a laparoscopic diagnosis with peritoneal fluid sampling for cytologic examination and biopsies of implants and of peritoneum to assure a correct diagnosis, a laparoscopic evaluation of extension with the American Fertility Society (AFS) 85 scoring system in order to classify the severity of the disease, and a laparoscopic treatment with the following strategy: drainage of the ovarian endometrioma and careful peritoneal washing, treatment of peritoneal implants, ovariolysis, treatment of the ovarian cysts, hemostasis and peritoneal lavage. Treatment of peritoneal implants is very easily performed by CO2 laser vaporization using a suprapubic puncture. Ovarian endometriomas are treated by laparoscopic cystectomy using a transparietal cystectomy or an intraperitoneal cystectomy. Laser vaporization is used only in case of small ovarian cysts or after an incomplete resection of a large cyst.Results of laparoscopic treatment of endometriosis compare favorably with those obtained with surgical procedures performed by laparotomy with the well known advantage of a laparoscopic approach.
First North American validation and head‐to‐head comparison of four preoperative nomograms for prediction of lymph node invasion before radical prostatectomy
Authors: Bandini Marco , Marchioni Michele , Pompe Raisa S. , Tian Zhe , Gandaglia Giorgio , Fossati Nicola , Abdollah Firas , Graefen Markus , Montorsi Francesco , Saad Fred , Shariat Shahrokh F. , Briganti Alberto , Karakiewicz Pierre I. 
Published: November 2017

ObjectivesTo perform a head‐to‐head comparison of four nomograms; namely, the Cagiannos, the 2012‐Briganti, the Godoy and the online‐Memorial Sloan Kettering Cancer Center (MSKCC), for prediction of lymph node invasion (LNI) in a North American population.Patients and MethodsA total of 19 775 patients with clinically localized prostate cancer (PCa) who had undergone radical prostatectomy and pelvic lymph node dissection (PLND) were identified within the Surveillance Epidemiology and End Results (SEER) database. All four nomograms were tested using Heagerty's concordance index (C‐index), calibration plots and decision curve analysis (DCA). In addition, we examined specific nomogram‐derived thresholds to compare the number of avoided PLNDs and missed LNI‐positive cases.ResultsAll nomograms were found to have highly comparable C‐index values: the Cagiannos, 78.6%; the Godoy, 78.2%; the 2012‐Briganti, 79.8%; and the MSKCC, 79.9%. The Cagiannos nomogram showed the best calibration, followed by the 2012‐Briganti, the Godoy and the online‐MSKCC. In DCA, the 2012‐Briganti and the Cagiannos, in that order, provided the best results, followed by the Godoy and the online‐MSKCC models. For each nomogram, the threshold associated with ≤10% missed LNI cases avoided 8 693 (46.6%), 8 652 (46.4%), 8 461 (45.4%) and 8 590 (46.1%) PLNDs, respectively, with the use of the Cagiannos (2.6% threshold), the online‐MSKCC (4.3% threshold), the Godoy (3.6% threshold) and the 2012‐Briganti (4.6% threshold) nomograms.ConclusionThe Cagiannos and the 2012‐Briganti nomograms exhibited the best calibrations and DCA results. Conversely, C‐index values and ability to avoid unnecessary PLNDs were virtually the same for all four nomograms examined.
The implications of baseline bone‐health assessment at initiation of androgen‐deprivation therapy for prostate cancer
Authors: Kirk Peter S. , Borza Tudor , Shahinian Vahakn B. , Caram Megan E.V. , Makarov Danil V. , Shelton Jeremy B. , Leppert John T. , Blake Ryan M. , Davis Jennifer A. , Hollenbeck Brent K. , Sales Anne , Skolarus Ted A. 
Published: November 2017

ObjectivesTo assess bone‐density testing (BDT) use amongst prostate cancer survivors receiving androgen‐deprivation therapy (ADT), and downstream implications for osteoporosis and fracture diagnoses, as well as pharmacological osteoporosis treatment in a national integrated delivery system.Patients and methodsWe identified 17 017 men with prostate cancer who received any ADT between 2005 and 2014 using the Veterans Health Administration cancer registry and administrative data. We identified claims for BDT within a 3‐year period of ADT initiation. We then used multivariable regression to examine the association between BDT use and incident osteoporosis, fracture, and use of pharmacological treatment.ResultsWe found that a minority of patients received BDT (n = 2 502, 15%); however, the rate of testing increased to >20% by the end of the study period. Men receiving BDT were older at diagnosis and had higher‐risk prostate cancer (both P < 0.001). Osteoporosis and fracture diagnoses, use of vitamin D ± calcium, and bisphosphonates were all more common in men who received BDT. After adjustment, BDT, and to a lesser degree ≥2 years of ADT, were both independently associated with incident osteoporosis, fracture, and osteoporosis treatment.ConclusionsBDT is rare amongst patients with prostate cancer treated with ADT in this integrated delivery system. However, BDT was associated with substantially increased treatment of osteoporosis indicating an underappreciated burden of osteoporosis amongst prostate cancer survivors initiating ADT. Optimising BDT use and osteoporosis management in this at‐risk population appears warranted.
Defining a glycated haemoglobin (HbA1c) level that predicts increased risk of penile implant infection
Authors: Habous Mohamad , Tal Raanan , Tealab Alaa , Soliman Tarek , Nassar Mohammed , Mekawi Zenhom , Mahmoud Saad , Abdelwahab Osama , Elkhouly Mohamed , Kamr Hatem , Remeah Abdallah , Binsaleh Saleh , Ralph David , Mulhall John 
Published: November 2017

ObjectivesTo re‐evaluate the role of diabetes mellitus (DM) as a risk factor for penile implant infection by exploring the association between glycated haemoglobin (HbA1c) levels and penile implant infection rates and to define a threshold value that predicts implant infection.Patients and MethodsWe conducted a multicentre prospective study including all patients undergoing penile implant surgery between 2009 and 2015. Preoperative, perioperative and postoperative management were identical for the entire cohort. Univariate analysis was performed to define predictors of implant infection. The HbA1c levels were analysed as continuous variables and sequential analysis was conducted using 0.5% increments to define a threshold level predicting implant infection. Multivariable analysis was performed with the following factors entered in the model: DM, HbA1C level, patient age, implant type, number of vascular risk factors (VRFs), presence of Peyronie's disease (PD), body mass index (BMI), and surgeon volume. A receiver operating characteristic (ROC) curve was generated to define the optimal HbA1C threshold for infection prediction.ResultsIn all, 902 implant procedures were performed over the study period. The mean patient age was 56.6 years. The mean HbA1c level was 8.0%, with 81% of men having a HbA1c level of >6%. In all, 685 (76%) implants were malleable and 217 (24%) were inflatable devices; 302 (33.5%) patients also had a diagnosis of PD. The overall infection rate was 8.9% (80/902). Patients who had implant infection had significantly higher mean HbA1c levels, 9.5% vs 7.8% (P < 0.001). Grouping the cases by HbA1c level, we found infection rates were: 1.3% with HbA1c level of <6.5%, 1.5% for 6.5–7.5%, 6.5% for 7.6–8.5%, 14.7% for 8.6–9.5%, 22.4% for >9.5% (P < 0.001). Patient age, implant type, and number of VRFs were not predictive. Predictors defined on multivariable analysis were: PD, high BMI, and high HbA1c level, whilst a high‐volume surgeon had a protective effect and was associated with a reduced infection risk. Using ROC analysis, we determined that a HbA1c threshold level of 8.5% predicted infection with a sensitivity of 80% and a specificity of 65%.ConclusionUncontrolled DM is associated with increased risk of infection after penile implant surgery. The risk is directly related to the HbA1c level. A threshold HbA1c level of 8.5% is suggested for clinical use to identify patients at increased infection risk.
The presentation of depression symptoms in attention‐deficit/hyperactivity disorder: comparing child and parent reports
Authors: Fraser Annie , Cooper Miriam , Agha Sharifah Shameem , Collishaw Stephan , Rice Frances , Thapar Anita , Eyre Olga 
Published: November 2017

BackgroundAttention‐deficit/hyperactivity disorder (ADHD) frequently co‐occurs with depression, and outcomes are poor when both are present. Little is known about whether depression symptoms present differently in ADHD compared to the general population, or how reliable young people with ADHD are at reporting these symptoms. This study aimed to describe depression symptoms in a clinical ADHD sample compared to a population sample, and compare self‐reports of depression symptoms with parent‐reports.MethodsTwo hundred and forty‐nine children with ADHD and their parents completed follow‐up questionnaires around 5 years after taking part in a Cardiff University ADHD study. Child depression symptoms were measured using parent‐ and child‐reported Mood and Feelings Questionnaires (MFQ) and compared to a population sample with MFQ data (n = 1460). Within both samples, child‐ and parent‐reported depression symptoms were compared.ResultsAlthough the profile of depression symptoms was similar between young people with ADHD and those in the general population, depression symptoms were much more common in the ADHD sample (parent‐rated MFQ score = 24.52 vs. 9.39; child‐rated = 21.02 vs. 11.86). The most common symptoms in both samples included irritability, restlessness and concentration difficulties, with core depression symptoms such as feeling miserable/unhappy also prominent. Within the ADHD sample, but not the population sample, children reported depression symptoms less frequently than their parents.ConclusionsYoung people with ADHD are at high risk of experiencing symptoms of depression but may under‐report the severity of their symptoms. Obtaining parent reports of depression symptoms in this group may be important to avoid missing key indicators of risk.
Clinical characteristics and outcomes of Castleman disease: A multicenter study of 185 Chinese patients
Authors: Zhang Xuanye , Rao Huilan , Xu Xiaolu , Li Zhihua , Liao Bing , Wu Hongmei , Li Mei , Tong Xiuzhen , Li Juan , Cai Qingqing 
Published: November 2017

Castleman disease (CD) is a rare lymphoproliferative disorder. To assess the clinical features, outcomes, and prognostic factors of this disease, we retrospectively analyzed 185 HIV‐negative CD patients from four medical centers in southern China. The median age was 37 years. One hundred and twenty‐one patients (65.4%) were classified as unicentric CD (UCD) and 64 patients (34.6%) were classified as multicentric CD (MCD). The histology subtype was hyaline‐vascular for 132 patients (71.4%), plasma cell for 50 patients (27%), and mixed type for 3 patients (1.6%). The 5‐year overall survival (OS) of 185 CD cases was 80.3%. All UCD patients underwent surgical excision, whereas the treatment strategies of MCD patients were heterogeneous. The outcome for UCD patients was better than MCD patients, with 5‐year OS rates of 93.6% and 51.2%, respectively. In further analysis of the MCD subgroup, a multivariate analysis using a Cox regression model revealed that age, splenomegaly and pretreatment serum albumin level were independent prognostic factors for OS. This multicenter study comprising the largest sample size to date suggested that MCD is a distinct entity from UCD with a significantly worse outcome. Older age (≥40 years), splenomegaly, and hypoalbuminemia were risk factors for poorer MCD prognosis.
The diagnostic value of tissue button technique for specimen accusation during endobronchial ultrasound‐guided transbronchial fine‐needle aspiration
Authors: Fruchter Oren , Breslavsky Anna , Brozgol Tatyana , Grossman Anna , Kessi Mikhailova , Bugayov Alexey , Shimelis Kassa , Vaknine Hananya , Sukmanov Oleg 
Published: November 2017

AbstractIntroductionThe quality of tissue acquisition during endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) is a major determinant of the diagnostic yield of the procedure. In the tissue button (TB) technique, the retrieved cellular specimen is fixed in ethanol and subsequently scraped from slide using surgical blade into formaldehyde and processed like ordinary tissue biopsy thus potentially increasing its diagnostic value.ObjectivesTo retrospectively evaluate the diagnostic yield of a TB technique in patients undergoing EBUS‐TBNA for various malignant and benign conditions.MethodsThe diagnostic yield of specimen obtained by two methods (TB and traditional cell‐block technique) performed during the same procedure are outlined in 46 patients who underwent EBUS‐TBNA (median age = 65, range 19‐85 years).ResultsOverall, in both malignant and benign conditions, TB resulted in clear diagnostic material in 43/46 (93.4%) patients. Specifically, TB provided clear histological diagnosis of malignancy (either primary lung cancer or metastases from extra‐thoracic cancer) in 30/46 (65.2%) patients and granulomatous inflammation in 11/46 (23.9%) of patients. Only in two patients TB did not provide diagnostic material.ConclusionsThe newly introduced TB technique provides valuable histological diagnostic material during EBUS‐TBNA both malignant and benign conditions. Given its simplicity and its high diagnostic yield, TB should be considered to be used as one of the preferred specimen acquisition modalities during EBUS‐TBNA specimen processing. Direct comparison to alternative tissue processing techniques during EBUS‐TBNA should be explored in further randomized prospective studies.
Transcripts immunoprecipitated with Sxl protein in primordial germ cells of Drosophila embryos
Authors: Ota Ryoma , Morita Shumpei , Sato Masanao , Shigenobu Shuji , Hayashi Makoto , Kobayashi Satoru 
Published: November 2017

In Drosophila, Sex lethal (Sxl), an RNA binding protein, is required for induction of female sexual identity in both somatic and germline cells. Although the Sxl‐dependent feminizing pathway in the soma was previously elucidated, the downstream targets for Sxl in the germline remained elusive. To identify these target genes, we selected transcripts associated with Sxl in primordial germ cells (PGCs) of embryos using RNA immunoprecipitation coupled to sequencing (RIP‐seq) analysis. A total of 308 transcripts encoded by 282 genes were obtained. Seven of these genes, expressed at higher levels in PGCs as determined by microarray and in situ hybridization analyses, were subjected to RNAi‐mediated functional analyses. Knockdown of Neos, Kap‐alpha3, and CG32075 throughout germline development caused gonadal dysgenesis in a sex‐dependent manner, and Su(var)2‐10 knockdown caused gonadal dysgenesis in both sexes. Moreover, as with knockdown of Sxl, knockdown of Su(var)2‐10 in PGCs gave rise to a tumorous phenotype of germline cells in ovaries. Because this phenotype indicates loss of female identity of germline cells, we consider Su(var)2‐10 to be a strong candidate target of Sxl in PGCs. Our results represent a first step toward elucidating the Sxl‐dependent feminizing pathway in the germline.
Transient elastic‐plastic‐creep crack‐tip stress fields under load‐controlled loading
Authors: Lee H.‐S. , Kim D.‐J. , Kim Y.‐J. , Ainsworth R.A. , Budden P.J. 
Published: November 2017

AbstractThis paper presents transient and steady‐state elastic‐plastic‐creep crack‐tip stress fields under load‐controlled loading conditions for a wide range of combinations of power‐law plastic and creep materials. The crack‐tip stress fields are characterized in terms of 2 parameters to accommodate the crack‐tip constraint effect; the C(t)‐ (or C*‐) integral and the βQ parameter (the Q‐parameter normalized with respect to the proximity parameter to plastic collapse). For practical application, the crack‐tip stress fields are re‐formulated explicitly in terms of time and crack‐tip stress fields for elastic‐plastic and steady‐state creep conditions. Comparison with detailed FE results for plane strain tension and bend specimens shows that this formulation of the crack‐tip stress fields agrees well with finite element results.
Beyond climate control on species range: The importance of soil data to predict distribution of Amazonian plant species
Authors: Figueiredo Fernando O. G. , Zuquim Gabriela , Tuomisto Hanna , Moulatlet Gabriel M. , Balslev Henrik , Costa Flávia R. C. 
Published: November 2017

AbstractAimTo evaluate the relative importance of climatic versus soil data when predicting species distributions for Amazonian plants and to gain understanding of potential range shifts under climate change.LocationAmazon rain forest.MethodsWe produced species distribution models (SDM) at 5‐km spatial resolution for 42 plant species (trees, palms, lianas, monocot herbs and ferns) using species occurrence data from herbarium records and plot‐based inventories. We modelled species distribution with Bayesian logistic regression using either climate data only, soil data only or climate and soil data together to estimate their relative predictive powers. For areas defined as unsuitable to species occurrence, we mapped the difference between the suitability predictions obtained with climate‐only versus soil‐only models to identify regions where climate and soil might restrict species ranges independently or jointly.ResultsFor 40 out of the 42 species, the best models included both climate and soil predictors. The models including only soil predictors performed better than the models including only climate predictors, but we still detected a drought‐sensitive response for most of the species. Edaphic conditions were predicted to restrict species occurrence in the centre, the north‐west and in the north‐east of Amazonia, while the climatic conditions were identified as the restricting factor in the eastern Amazonia, at the border of Roraima and Venezuela and in the Andean foothills.Main conclusionsOur results revealed that soil data are a more important predictor than climate of plant species range in Amazonia. The strong control of species ranges by edaphic features might reduce species’ abilities to track suitable climate conditions under a drought‐increase scenario. Future challenges are to improve the quality of soil data and couple them with process‐based models to better predict species range dynamics under climate change.
The Promise and Future of Neo‐Functional Peace: A Reply to Bergmann and Niemann
Authors: Visoka Gëzim , Doyle John 
Published: November 2017

AbstractJulian Bergmann and Arne Niemann claim that ‘neo‐functional peace’ was insufficiently conceptualized and empirically unsubstantiated. They draw on the original neo‐functionalist literature to propose a logic of spillover to explain the European Union's external policies. We argue that our original article is not damaged by this critique and its explanation of the EU's approach in the Serbia‐Kosovo case stands. We accept the need for further work, based on analysis of different examples and sectors, which can clarify the conceptual boundaries of neo‐functional peace and test it against other cases.
Integration of dermoscopy and reflectance confocal microscopy for distinguishing melanomas from nevi of the breast area
Authors: Mandel V.D. , Bombonato C. , Pampena R. , Kyrgidis A. , Borsari S. , Benati E. , Mirra M. , Piana S. , Pellacani G. , Longo C. 
Published: November 2017

AbstractBackgroundNevi of special sites encompass a class of benign lesions characterized by the presence of atypical clinical and histopathological features that can be difficult to distinguish from melanoma. Dermoscopy and reflectance confocal microscopy may improve the clinical assessment of melanocytic lesions to avoid unnecessary excisions.ObjectivesThe aim of this study was to assess the value of specific dermoscopic and confocal criteria in distinguishing melanomas from nevi of the breast area.MethodsDermoscopic and confocal images from consecutive patients with at least one clinically and/or dermoscopically equivocal melanocytic skin lesion of the breast area were retrospectively evaluated. In this case–control study, only histopathologically proven melanomas (cases) and nevi (controls) were included. Spearman's coefficients were first calculated to flag significant correlation; then univariate and multivariate logistic regression analyses were performed to assess which factors were independently associated with the histopathological diagnosis. Finally, a mixed dermoscopic/confocal score was created to distinguish nevi from melanomas on the breast area.ResultsThe study population included 55 skin lesions of the breast area, 34 (61.8%) nevi and 21 (38.2%) melanomas. Among dermoscopic criteria, atypical network and irregular pigmentation resulted independently associated with melanoma diagnosis (OR: 11.1; 95% CI 1.0–119.9; P:0.048 and OR: 6.5; 95% CI 1.1–37.5; P:0.037, respectively). Furthermore, on RCM examination, the presence of pagetoid cells was an independent positive predictor for melanoma (OR: 38.5; 95% CI 3.9–379.6; P:0.002). The mixed score showed high levels of sensitivity and specificity, 95.2% and 82.4%, respectively, which were higher than dermoscopic and confocal evaluations alone.ConclusionThe combined use of dermoscopy and confocal microscopy in the triage of pigmented lesions of the breast area may help in increasing the diagnostic accuracy and avoiding unnecessary excisions.
An evaluation of the impact of FIFA World Cup on soccer emergency department injuries among Montreal adolescents
Authors: Keays Glenn , Friedman Debbie , Beaudin Marianne , Gagnon Isabelle 
Published: November 2017

AimThe ‘trickle‐down effect’, or how major sports events have a positive impact on sports participation, has been the subject of many studies, but none produced conclusive results. We took a different approach and rather than look at sports participation, we used injuries as a proxy and see if injuries increased, or remained the same, after the International Federation of Association Football World Cup.MethodsUsing a retrospective cohort design, we looked at the injuries suffered by males and females (13–16 years old) while playing team sports in Montreal, that occurred in May to July, from 1999 to 2014. Information reported by the Canadian Hospitals Injury Reporting Prevention Program (CHIRPP) was limited to the two CHIRPP centres in Montreal: the Montreal Children's Hospital and Hopital Sainte‐Justine.ResultsIn females, no significant trends were noticed. In males who played non‐organised soccer, the percent changes between FIFA World Cup (WC) (June) and pre‐FIFA WC (May) was always highest during FIFA WC years: 17.2% more injuries in years when FIFA WC was held compared to 1.3% less injuries during non‐FIFA WC years. In non‐organised soccer, male players suffered less strains/sprains (11.9% vs. 30.1%; P = 0.015), suffered more severe injuries (59.7% vs. 43.1%; P = 0.049) and more of their injuries were the results of direct contact with another player (26.8% vs. 13.3%; P = 0.028) during FIFA WC.ConclusionFIFA WC seems to have an impact on the injuries of teenage boys when playing non‐organised soccer. The impact was short‐lived, only lasting during the FIFA WC event.