bluuebunny/crossref_metadata_2025_split huggingface dataset:
Controlling Differentiation of Stem Cells for Developing Personalized Organ‐on‐Chip Platforms
Authors: Geraili Armin , Jafari Parya , Hassani Mohsen Sheikh , Araghi Behnaz Heidary , Mohammadi Mohammad Hossein , Ghafari Amir Mohammad , Tamrin Sara Hasanpour , Modarres Hassan Pezeshgi , Kolahchi Ahmad Rezaei , Ahadian Samad , Sanati‐Nezhad Amir 
Published: September 2017

AbstractOrgan‐on‐chip (OOC) platforms have attracted attentions of pharmaceutical companies as powerful tools for screening of existing drugs and development of new drug candidates. OOCs have primarily used human cell lines or primary cells to develop biomimetic tissue models. However, the ability of human stem cells in unlimited self‐renewal and differentiation into multiple lineages has made them attractive for OOCs. The microfluidic technology has enabled precise control of stem cell differentiation using soluble factors, biophysical cues, and electromagnetic signals. This study discusses different tissue‐ and organ‐on‐chip platforms (i.e., skin, brain, blood–brain barrier, bone marrow, heart, liver, lung, tumor, and vascular), with an emphasis on the critical role of stem cells in the synthesis of complex tissues. This study further recaps the design, fabrication, high‐throughput performance, and improved functionality of stem‐cell‐based OOCs, technical challenges, obstacles against implementing their potential applications, and future perspectives related to different experimental platforms.
Asymmetric Vinylogous Aldol Reaction of α‐ketoesters with 3‐alkylidene oxindoles
Authors: Kumar Krishna , Jaiswal Manish K. , Singh Ravi P. 
Published: September 2017

AbstractAn efficient enantioselective vinylogous aldol reaction of 3‐alkylidene oxindoles with α‐ketoesters by a bifunctional thiourea catalyst derived from cinchona alkaloid has been disclosed here. The simultaneous H‐bond directing dual activation of vinylogous nucleophile and electrophile afforded high yield (upto 92%) while obtaining excellent stereocontrol (upto 99% ee).magnified image
Organocatalyzed Thia‐Michael Addition and Sequential Inverse Electron Demanding Diels‐Alder Reaction to 3‐Vinyl‐1,2,4‐ triazine Platforms
Authors: Berthonneau Clément , Buttard Floris , Hiebel Marie‐Aude , Suzenet Franck , Brière Jean‐François 
Published: September 2017

AbstractThis work highlights the use of 3‐vinyl‐1,2,4‐triazines as original thia‐Michael acceptors and inverse electron demanding Diels‐Alder platforms en route to new 7,8‐dihydro‐5H‐thiopyrano[4,3‐b]pyridines. The required but rather unstable propargylthiol nucleophiles were successfully generated in‐situ upon an innovative DBU‐catalyzed methanolysis event of the corresponding propargyl thioacetate derivatives.magnified image
Efficient Transformation of Alkyl 3‐nitro‐5‐(aryl/alkyl)isoxazole‐4‐carboxylates into 3‐amino‐ and 3‐hydrazinyl‐5‐aryl/alkyl‐isoxazole‐4‐carboxylates in Aqueous Solution
Authors: Mukhopadhyay Sushobhan , Barak Dinesh S. , Avasthi Ilesha , Batra Sanjay 
Published: September 2017

AbstractAn efficient protocol for transforming alkyl 3‐nitro‐5‐(aryl/alkyl)isoxazole‐4‐carboxylates into 3‐amino‐ and 3‐hydrazinyl‐5‐aryl/alkyl‐isoxazole‐4‐carboxylates is described. The reaction that is carried out in aqueous acetonitrile solution generally afford the products without any chromatographic purification. Investigations with the substrate scope reveal that this protocol is compatible only when the ester group is present at the C‐4 position of the isoxazole ring.magnified image
Potassium Hydroxide‐Catalyzed Alkynylation of Heteroaromatic N‐Oxides with Terminal Alkynes
Authors: Chen Xiaopei , Yang Fangfang , Cui Xiuling , Wu Yangjie 
Published: September 2017

AbstractAn efficient potassium hydroxide‐catalyzed alkynylation of heteroaromatic N‐oxides under transition‐metal‐free conditions with the assistance of visible‐light has been developed. Various C2‐alkynylheterocycles were obtained in up to 92% yield with good functional group tolerance. This new method is operational simple, highly efficient, atom economic, and environmental friendly.magnified image
Influence of filler loading and palm oil‐based green coupling agent on torque rheological properties of polypropylene/cocoa pod husk composites
Authors: Koay Seong Chun , Chan Ming Yeng , Pang Ming Meng , Tshai Kim Yeow 
Published: September 2017

AbstractThis research examined the torque rheological properties of cocoa pod husk (CPH)‐filled polypropylene (PP) composites. Composites with varying filler loading ranging from 10 to 40 phr and formulation with or without palm oil‐based green coupling agent (GCA‐P) were analyzed using a Brabender Plastrograph torque rheometer. The GCA‐P synthesized from fatty acid of palm oil was used to enhance adhesion at the filler–matrix surface interfaces. The results reveal that PP/CPH composites containing 40 phr filler loading and GCA‐P exhibited higher processing torque and power law index (n). Higher melt viscosity was recorded at higher filler loading, owning to filler agglomeration and more effective filler‐matrix adhesion in the presence of GCA‐P. As a result, higher energy was required to compound PP/CPH composites, which could be attributed to the increase in activation energy (Ea) at higher melt viscosity.
The influence of hydrophilic mPEG segment on formation, morphology, and properties of PCL‐mPEG microspheres
Authors: He Yu , Liu Ping , Shi Chen , Liu Yongwei , Liu Songxiang , Feng Xiaobo , Fu Dehao 
Published: September 2017

AbstractThis research displayed the differences of formation process, morphology, degradation, and release behaviors between PCL and PCL‐mPEG microspheres. Lysozyme loaded microspheres were prepared by double emulsion evaporation method, and the double droplets transformation process was observed and compared under microscope. Microspheres morphology, in vitro degradation and release behaviors were evaluated by scanning electron microscope, gel permeation chromatography, and bicinchoninic acid protein assay kit. PCL‐mPEG microspheres got a rough surface and the outer water phase penetrated into PCL‐mPEG double droplet easier than PCL during the transformation, accompanied with a high broken percentage and size swelling. PCL‐mPEG microspheres get a faster degradation/erosion rate than PCL microspheres, and the rate was in direct proportion to mPEG chain length. In vitro release analysis showed that PCL‐mPEG microspheres get a faster release rate than PCL microspheres, and the rate was also in direct proportion to mPEG chain length.
Stabilizing the Efficiency Beyond 20% with a Mixed Cation Perovskite Solar Cell Fabricated in Ambient Air under Controlled Humidity
Authors: Singh Trilok , Miyasaka Tsutomu 
Published: September 2017

AbstractPerovskite solar cells have evolved to have compatible high efficiency and stability by employing mixed cation/halide type perovskite crystals as pinhole‐free large grain absorbers. The cesium (Cs)–formamidium–methylammonium triple cation‐based perovskite device fabricated in a glove box enables reproducible high‐voltage performance. This study explores the method to reproduce stable and high power conversion efficiency (PCE) of a triple cation perovskite prepared using a one‐step solution deposition and low‐temperature annealing fully conducted in controlled ambient humidity conditions. Optimizing the perovskite grain size by Cs concentration and solution processes, a route is created to obtain highly uniform, pinhole‐free large grain perovskite films that work with reproducible PCE up to 20.8% and high preservation stability without cell encapsulation for more than 18 weeks. This study further investigates the light intensity characteristics of open‐circuit voltage (Voc) of small (5 × 5 mm2, PCE > 20%) and large (10 × 10 mm2, PCE of 18%) devices. Intensity dependence of Voc shows an ideality factor in the range of 1.7‐1.9 for both devices, implying that the triple cation perovskite involves trap‐assisted recombination loss at the hetero junction interfaces that influences Voc. Despite relatively high ideality factor, perovskite device is capable of supplying high power conversion efficiency under low light intensity (0.01 Sun) whereas maintaining Voc over 0.9 V.
Microstructural Characterisations of Perovskite Solar Cells – From Grains to Interfaces: Techniques, Features, and Challenges
Authors: Rothmann Mathias Uller , Li Wei , Etheridge Joanne , Cheng Yi‐Bing 
Published: September 2017

AbstractOrganic‐inorganic hybrid perovskite solar cells form a new type of thin film photovoltaic technology, which has achieved extraordinary improvements in power conversion efficiency in a relatively short time. To further improve the efficiency and stability of the perovskite solar cells, it is critical to understand and control the microstructure of both the functional materials and their interfaces. Much effort has already been made to understand the microstructure of perovskite solar cells and its influence on their performance. This has proved particularly challenging due to the fragile nature of the organic‐inorganic perovskites and the consequent potential for generating artefacts through the application of the characterization methods themselves. In this progress report, an overview of some of the more commonly used characterization methods is given, their possible impact on the materials analyses is evaluated, and the latest developments in the understanding of the microstructure of perovskite solar cells are summarized. The heterogenic nature of the individual perovskite grains and the polycrystalline film as a whole is illustrated, the features and properties of the grain boundaries and the effect they can have on solar cell performance are described, and the interface characterization between the layers in the solar cell devices is discussed.
A case of paraplegia that developed 6 years after thoracic endovascular aortic repair for blunt traumatic aortic injury
Authors: Takahashi Hiroyuki , Shoko Tomohisa , Taketazu Fumino , Kuriyama Keiichi , Yoshikawa Kazuhide , Deguchi Yoshizumi 
Published: September 2017

CaseThoracic endovascular aortic repair (TEVAR) is becoming the standard therapy for blunt thoracic aortic injury (BTAI). However, the long‐term outcomes of TEVAR for BTAI remain unclear. A 36‐year‐old man was admitted to our emergency department with dyspnea. He had been involved in a serious traffic accident 6 years earlier, requiring TEVAR for BTAI.OutcomeAcute heart failure and pneumonia were diagnosed on this admission. His respiratory condition improved, but paraplegia developed 10 h after hospitalization. Magnetic resonance imaging showed an intraspinal longitudinal area of signal hyperintensity, and spinal cord infarction was diagnosed.ConclusionAlthough the causal relationship between the TEVAR and spinal cord infarction remains unclear, paraplegia as a long‐term complication after TEVAR does not appear to have been reported previously, and so represents a potentially important complication.
Synthesis of Acylborons by Ozonolysis of Alkenylboronates: Preparation of an Enantioenriched Amino Acid Acylboronate
Authors: Taguchi Jumpei , Ikeda Toshiki , Takahashi Rina , Sasaki Ikuo , Ogasawara Yasushi , Dairi Tohru , Kato Naoya , Yamamoto Yasunori , Bode Jeffrey W. , Ito Hajime 
Published: September 2017

AbstractA concise synthesis of acylborons was achieved by ozonolysis of alkenyl MIDA (N‐methyliminodiacetic acid) boronates. This reaction exhibits excellent functional‐group tolerance and is applicable to various acyl MIDA boronates and potassium acyltrifluroborates (KATs) which could not be synthesized by previous methods. In addition, α‐amino acylborons, which would be essential for peptide ligations, were prepared for the first time. The acylboron of l‐alanine was obtained in high enantiopurity and found to be configurationally stable. Oligopeptide synthesis between the α‐amino KATs and amino acid in dilute aqueous media was studied.
Verringerung der Virulenz von multiresistentem Staphylococcus aureus mithilfe eines chemischen Disruptors des ClpX‐Chaperon‐Komplexes
Authors: Fetzer Christian , Korotkov Vadim S. , Thänert Robert , Lee Kyu Myung , Neuenschwander Martin , von Kries Jens Peter , Medina Eva , Sieber Stephan A. 
Published: September 2017

AbstractDie ClpXP‐Protease von Staphylococcus aureus ist ein wichtiger Regulator der Zellhomöostase und Virulenz. Mithilfe eines Hochdurchsatz‐Screenings gegen den ClpXP‐Komplex wurde ein spezifischer Inhibitor des ClpX‐Chaperons identifiziert, der den oligomeren Zustand zerstört. Die Synthese von 34 Derivaten offenbarte, dass das molekulare Grundgerüst nur eingeschränkte Veränderungen ermöglicht und nur geringe Änderungen toleriert werden. Eine Analyse der aktivsten Verbindungen zeigte eine starke Verringerung der Toxinproduktion von S. aureus, die durch eine maßgeschneiderte, MS‐basierte Assayplattform quantifiziert wurde. Transkriptom‐ und Gesamtproteomstudien bestätigten die globale Virulenzreduktion und enthüllten eine charakteristische Signatur der Proteinexpression in mit Substanz behandelten Zellen. Obwohl diese Signatur teilweise mit dem Muster der ClpX‐Deletionszellen übereinstimmte, wurde eine weitere Verringerung der Toxine beobachtet, was zu der vielversprechenden Möglichkeit führt, dass weitere Virulenzpfade direkt oder indirekt von der niedermolekularen Verbindung adressiert werden könnten.
Humidity regulation by stretched PP and PLA films with dispersed CaCl2
Authors: Sängerlaub Sven , Miesbauer Oliver , Michael Linda , Müller Kajetan , Stramm Cornelia , Pecyna Marek , Langowski Horst‐Christian 
Published: September 2017

ABSTRACTPolymer materials that regulate the relative humidity in their environment are relevant for applications in the packaging and building sectors. By integration of salts in polymer structures, such materials are able to absorb and desorb high amounts of water vapor. In this study, films of polylactic acid and polypropylene with dispersed calcium chloride (2 and 4 wt %) were produced and biaxially stretched to induce the formation of cavities. The resulting cavities in these films account up to 10 vol % and are able to contain emerging calcium chloride solution formed by water vapor absorption. These films absorb reversibly up to 15 wt % water vapor at 75% relative humidity at 23 °C. This absorption behavior is described by effective diffusion and effective sorption coefficients. Using a simple model, the effective water vapor diffusion coefficient of these films can be estimated from the permeation coefficient of the polymer and the sorption coefficient of the absorber. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45713.
Simultaneous determination of boscalid and fludioxonil in grape and soil under field conditions by gas chromatography/tandem triple quadrupole mass spectrometry
Authors: Zhang Haizhen , Zhang A'wei , Huang Min , Yu Weiwei , Li Zhurui , Wu Sizhuo , Zheng Kunming , Zhang Kankan , Hu Deyu 
Published: September 2017

AbstractA gas chromatography–tandem mass spectrometry method was developed and validated to simultaneously determine boscalid and fludioxonil in grape and soil samples. These samples were extracted with 10 mL of acetonitrile and purified using a mixed primary secondary amine/octadecylsilane sorbent. The method showed good linearity (R2 > 0.99) in the calibration range 0.005–2 μg/mL for both pesticides. The limits of detection and quantification for the two analytes in grape and soil were 0.006 and 0.02 mg/kg, respectively. Fungicide recoveries in grape and soil were 81.18–92.11% for boscalid and 82.73–97.67% for fludioxonil with relative standard deviations of 1.31–10.31%. The established method was successfully applied to the residual analysis of boscalid and fludioxonil in real grape and soil samples. The terminal residue concentrations of boscalid and fludioxonil in grape samples collected from Anhui and Guizhou were <5 mg/kg (the maximum residue limit set by China) 7 days after the last application and 1 mg/kg (the maximum residue limit set by USA) 14 days after the last application. These results could provide guidance for the proper and safe use of boscalid and fludioxonil in grape and help the Chinese government to establish an MRL for fludioxonil in grape.
Anti‐inflammatory activities and glycerophospholipids metabolism in KLA‐stimulated RAW 264.7 macrophage cells by diarylheptanoids from the rhizomes of Alpinia officinarum
Authors: Zhang Guogai , Zhao Lifang , Zhu Jiancheng , Feng Yifan , Wu Xia 
Published: September 2017

AbstractAlpinia officinarum is used for its anti‐inflammatory activity historically in China. Diarylheptanoids isolated from A. officinarum play important biological roles in the prevention and treatment of inflammatory disorders. Seven diarylheptanoids (1–7) were isolated from A. officinarum. The cell viabilities and anti‐inflammatory activities of diarylheptanoids were evaluated by MTT assay and tumor necrosis factor‐α production in Kdo2‐lipid A‐stimulated RAW 264.7 cells in vitro. The relationships between their anti‐inflammatories and structure‐activities are discussed. The results indicated that compounds 1 and 3–7 had significant anti‐inflammatory activities. The relationships between inflammation and phospholipids metabolism were elucidated by multivariate data analysis. Twenty‐two potential biomarkers were identified in inflammatory group vs. blank group, and 11 potential biomarkers were identified for inflammatory group vs. drug‐treatment groups. Ten common phospholipids were characterized. On the basis of a previous study in our laboratory, we found that phosphatidylethanolamine (18:0/18:1) might be the important glycerophospholipid biomarker in inflammation. In this study, we firstly combined anti‐inflammatory activities and glycerophospholipids changes of traditional Chinese medicine. This work suggests that the anti‐inflammatory activities of diarylheptanoids might be significantly related to glycerophospholipids and could provide a useful database for investigating the anti‐inflammatory effects of traditional Chinese medicine.
β‐carotene suppresses Porphyromonas gingivalis lipopolysaccharide‐mediated cytokine production in THP‐1 monocytes cultured with high glucose condition
Authors: Kajiura Yukari , Nishikawa Yasufumi , Lew Jung Hwan , Kido Jun‐ichi , Nagata Toshihiko , Naruishi Koji 
Published: September 2017

AbstractPeriodontitis is associated with development of diabetes mellitus. Although lipopolysaccharide (LPS) of Porphyromonas gingivalis (Pg), a major pathogen of periodontitis, may lead the progression of diabetes complications, the precise mechanisms are unclear. We, therefore, investigated the effects of β‐carotene on production of Pg LPS‐induced inflammatory cytokines in human monocytes cultured high glucose (HG) condition. THP‐1 cells were cultured under 5.5 mM or 25 mM glucose conditions, and cells were stimulated with Pg LPS. To investigate the productivity of TNF‐α, IL‐6, and MCP‐1, cell supernatants were collected for ELISA. To examine the effects of NF‐kB signals on cytokine production, Bay11‐7082 was used. HG enhanced Pg LPS‐induced production of TNF‐α, IL‐6, and MCP‐1 via NF‐kB signals in THP‐1. β‐carotene suppressed the enhancement of the Pg LPS‐induced cytokine production in THP‐1 via NF‐κB inactivation. Our results suggest that β‐carotene might be a potential anti‐inflammatory nutrient for circulating Pg LPS‐mediated cytokine production in diabetic patients with periodontitis.
On the Mechanism of Connecting Deltahedral Zintl Clusters via Conjugated Buta‐1,3‐dien‐1,4‐diyl Functionalities: Synthesis and Structure of [Ge9−CH=CH−CH=CH−Ge9]6−
Authors: Bentlohner Manuel M. , Frischhut Sabine , Fässler Thomas F. 
Published: September 2017

AbstractWe report on the synthesis and structure, as well as on the mechanism of formation of the [Ge9−CH=CH−CH=CH−Ge9]6− unit. As shown by in situ NMR spectroscopy (1H, COSY, HSQC, HMBC), both (1Z,3Z)‐ and (1E,3Z)‐[Ge9−CH=CH−CH=CH−Ge9]6− are formed during the reaction of a mixture of 1,4‐bis(trimethylsilyl)butadiyne and A4Ge9 (A=K, Rb) with ethylenediamine. However, upon layering of the obtained solution with 222‐crypt/toluene (222‐crypt=4,7,13,16,21,24‐hexaoxa‐1,10‐diazabicyclo‐[8.8.8]hexacosan) only the (1Z,3Z)‐isomer crystallizes as {[A(222‐crypt)]6[(1Z,3Z)‐(Ge9−CH=CH−CH=CH−Ge9)]}(tol)2(en)2 (A=K, Rb) salts. Single crystals of these salts were characterized by X‐ray structure analysis and Raman spectroscopy, indicating the presence of three superimposed conformers of (1Z,3Z)‐[Ge9−CH=CH−CH=CH−Ge9]6−, which show different orientations of the cluster units with respect to the planar (1Z,3Z)‐buta‐1,3‐dien‐1,4‐diyl linker unit.
Phosphorus and Fluorine Co‐Doping Induced Enhancement of Oxygen Evolution Reaction in Bimetallic Nitride Nanorods Arrays: Ionic Liquid‐Driven and Mechanism Clarification
Authors: Bai Xue , Wang Qin , Xu Guangran , Ning Yunkun , Huang Keke , He Feng , Wu Zhi‐jian , Zhang Jun 
Published: September 2017

AbstractElectrocatalytic splitting of water is becoming increasingly crucial for renewable energy and device technologies. As one of the most important half‐reactions for water splitting reactions, the oxygen evolution reaction (OER) is a kinetically sluggish process that will greatly affect the energy conversion efficiency. Therefore, exploring a highly efficient and durable catalyst to boost the OER is of great urgency. In this work, we develop a facile strategy for the synthesis of well‐defined phosphorus and fluorine co‐doped Ni1.5Co1.5N hybrid nanorods (HNs) by using ionic liquids (ILs; 1‐butyl‐3‐methylimidazolium hexafluorophosphate). In comparison to the IrO2 catalyst, the as‐obtained PF/Ni1.5Co1.5N HNs manifests a low overpotential of 280 mV at 10 mA cm−2, Tafel slope of 66.1 mV dec−1, and excellent durability in 1.0 m KOH solution. Furthermore, the iR‐corrected electrochemical results indicate it could achieve a current density of 100 mA cm−2 at an overpotential of 350 mV. The combination of cobalt and nickel elements, 1D mesoporous nanostructure, heteroatom incorporation, and ionic liquid‐assisted nitridation, which result in faster charge transfer capability and more active surface sites, can facilitate the release of oxygen bubbles from the catalyst surface. Our findings confirm that surface heteroatom doping in bimetallic nitrides could serve as a new class of OER catalyst with excellent catalytic activity.
Total Synthesis of Skyllamycins A–C
Authors: Giltrap Andrew M. , Haeckl F. P. Jake , Kurita Kenji L. , Linington Roger G. , Payne Richard J. 
Published: September 2017

AbstractThe skyllamycins are a family of highly functionalized non‐ribosomal cyclic depsipeptide natural products which contain the extremely rare α‐OH‐glycine functionality. Herein the first total synthesis of skyllamycins A–C is reported, together with the biofilm inhibitory activity of the natural products. Linear peptide precursors for each natural product were prepared through an efficient solid‐phase route incorporating a number of synthetic modified amino acids. A novel macrocyclization step between a C‐terminal amide and an N‐terminal glyoxylamide moiety served as a key transformation to install the unique α‐OH‐glycine unit and generate the natural products in the final step of the synthesis.