bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling neuroanatomical variation due to age and sex during childhood and adolescence
Authors: Ball Gareth , Adamson Chris , Beare Richard , Seal Marc L. ,   the Pediatric Imaging, Neurocognition and Genetics
Published: April 2017

AbstractBrain development is a dynamic process that follows a well-defined trajectory during childhood and adolescence with tissue-specific alterations that reflect complex and ongoing biological processes. Accurate identification and modelling of these anatomical processesin vivowith MRI may provide clinically useful imaging markers of individual variability in development. In this study, we build a model of age- and sex-related anatomical variation using multiple imaging metrics and manifold learning.Using publicly-available data from two large, independent developmental cohorts (n=768, 862), we apply a multi-metric machine learning approach combining measures of tissue volume, cortical area and cortical thickness into a low-dimensional data representation.We find that neuroanatomical variation due to age and sex can be captured by two orthogonal patterns of brain development and we use this model to simultaneously predict age with a mean error of 1.5-1.6 years and sex with an accuracy of 81%.We present a framework for modelling anatomical development during childhood using manifold embedding. This model accurately predicts age and sex based on image-derived markers of cerebral morphology and generalises well to independent populations.
Intermolecular disulfide-bond formation in human FICD modulates the activity of the hyperactive E234G mutant
Authors: Magnoni Raffaella , Virolainen Minttu S. , Hackney Celeste M. , Søltoft Cecilie L. , Cordeiro Ana P. , Liu Yun , Scavenius Carsten , Enghild Jan J. , Christensen Brian , Paton James , Paton Adrienne W. , Sørensen Esben S. , Ellgaard Lars 
Published: April 2017

AbstractEndoplasmic reticulum (ER) stress that leads to the accumulation of misfolded proteins in the ER initiates the unfolded protein response (UPR). This homeostatic response activates signaling pathways that seek to reinstate a proper ER protein folding balance or induce apoptosis if ER stress persists. Recently, we and others identified human FICD (Filamentation induced by cyclic AMP domain-containing protein), an enzyme with adenylyltransferase (aka AMPylation) activity, as a new UPR target. Here, we demonstrate that FICD is functionally linked to the UPR, as evidenced by the finding that the adenylyltransferase activity of the protein induces ER stress, while FICD silencing increases sensitivity to ER stress. We identify BiP, an abundant ER chaperone and key regulator of the UPR, as the main substrate of FICD AMPylation in ER-derived microsomes, further emphasizing close functional connection of FICD to the UPR and in line with recent reports that AMPylation inactivates BiP. Notably, BiP overexpression increased the levels of BiP AMPylation as well as FICD auto-AMPylation, suggesting a homeostatic response that balances the pool of active BiP to modulate its functions in protein folding as well as UPR signaling. Finally, we show that overexpressed FICD forms a disulfide-bonded homo-dimer through Cys51 and Cys75 and demonstrate that mutation of these two cysteines in the context of a hyperactive FICD mutant leads to increased BiP AMPylation. This latter finding opens up the possibility that FICD activity is redox regulated and closely connected with ER redox homeostasis.
Chaperonin facilitates protein folding by avoiding polypeptide collapse
Authors: Motojima Fumihiro , Fujii Katsuya , Yoshida Masasuke 
Published: April 2017

AbstractChaperonins assist folding of many cellular proteins, including essential proteins for cell viability. However, it remains unclear how chaperonin-assisted folding is different from spontaneous folding. Chaperonin GroEL/GroES facilitates folding of denatured protein encapsulated in its central cage but the denatured protein often escapes from the cage to the outside during reaction. Here, we show evidence that the in-cage-folding and the escape occur diverging from the same intermediate complex in which polypeptide is tethered loosely to the cage and partly protrudes out of the cage. Furthermore, denatured proteins in the chaperonin cage start their folding from extended conformations but not from compact conformations as usually observed in spontaneous folding. We propose that the formation of tethered intermediate of polypeptide is necessary to prevent polypeptide collapse at the expense of polypeptide escape. The tethering of polypeptide would allow freely mobile portions of tethered polypeptide to fold segmentally. The folding acceleration and deceleration by chaperonin for various substrate proteins can be explained by considering the tethering.
High Accuracy Base Calls in Nanopore Sequencing
Authors: Faucon Philippe , Trevino Robert , Balachandran Parithi , Standage-Beier Kylie , Wang Xiao 
Published: April 2017

AbstractNanopore sequencing has introduced the ability to sequence long stretches of DNA, enabling the resolution of repeating segments, or paired SNPs across long stretches of DNA. Unfortunately significant error rates >15%, introduced through systematic and random noise inhibit downstream analysis. We propose a novel method, using unsupervised learning, to correct biologically amplified reads before downstream analysis proceeds. We also demonstrate that our method has performance comparable to existing techniques without limiting the detection of repeats, or the length of the input sequence.
Sensitivity to statistical structure facilitates perceptual analysis of complex auditory scenes
Authors: Aman Lucie , Picken Samantha , Andreou Lefkothea-Vasiliki , Chait Maria 
Published: April 2017

The notion that sensitivity to the statistical structure of the environment is pivotal to perception has recently garnered considerable attention. Here we investigated this issue in the context of hearing. Building on previous work (Sohoglu & Chait, 2016b), stimuli were artificial ‘sound-scapes’ populated by multiple (up to 14) simultaneous sources (‘auditory objects’) comprised of tone-pip sequences, each with a distinct frequency and pattern of amplitude modulation. Sequences were either temporally regular or random.We show that listeners’ ability to detect abrupt appearance or disappearance of a source is facilitated when scene sources were characterized by a temporally regular fluctuation pattern. The patterning of the changing source as well as that of the background (non-changing) sources contribute independently to this effect. Remarkably, listeners benefit from regularity even when they are not consciously aware of it. These findings establish that perception of complex acoustic scenes relies on the availability of detailed representations of the regularities automatically extracted from each scene source.
A tale of many auctions: mobile communications in India struggle to overcome a dysfunctional structure
Authors: Curwen Peter , Whalley Jason 
Published: April 2017

Purpose
The purpose of the paper is to assess whether the dysfunctional structure of the Indian mobile communications sector has been improved by a large number of spectrum auctions during the period 2010-2016.

Design/methodology/approach
This paper provides a case study of developments in the Indian mobile communications sector primarily during the period 2010-2016. This period has witnessed a large number of spectrum auctions, the results of which are presented and analysed. The particular focus is upon the consequences of these auctions for the structure of the sector which began the period in what can best be described as a dysfunctional state.

Findings
The paper concludes that only limited progress has so far been made in improving the structure of the sector. This is due to factors such as political interference, delays in completing merger & acquisition (M&A) activity, badly organised auctions, a scarcity of the right amount of spectrum in the right places and a regional structure that inhibits operators from providing a nationwide presence.

Practical implications
The paper concludes that considerable progress still needs to be made: For example, political interference needs to be harmonised, auction prices need to become market-clearing and M&A activity needs to come to fruition.

Originality/value
The existing analysis of the sector has paid only limited attention to the significance of auctions for the structure of the sector, and this paper provides an analysis of all auctions and M&A activity virtually to the end of 2016, making it unusually up-to-date.
Authorship of Iranian chemistry articles: an actuarial approach
Authors: Nikzad Mahsa , Hariri Nadjla , Babalhavaeji Fahimeh , Nooshinfard Fatemeh 
Published: April 2017

Purpose
This study aims to apply some concepts of actuarial statistics to the authorship of Iranian ISI papers in the field of chemistry based on Price’s model. The study determines scientific birth rate, death rate, infant mortality rate, natural increase rate and life expectancy.

Design/methodology/approach
Price maintained that authors in each given period in any field fall into four categories including newcomers, transients, continuants and terminators. He suggested that actuarial statistics could be applied to authorship to calculate death rate and birth rate in scientific fields. A total 25,573 papers written by 59,661 Iranian chemistry authors between 1973 and 2012 were downloaded from Web of Science (WoS) and were subjected to statistical analysis.

Findings
The average birth rate was 66.7 per cent, the average death rate was 19.4 per cent, infant mortality rate was 51.2 per cent, average natural increase was 47.3 per cent, the average life expectancy was 1.98 years and the longest scientific age was 22 years. The results show that although a large number of people start their scientific activity, the number of those who terminate their activity in the same year as they start (infant mortality rate) is also large and little continuity exists in the publishing activities of Iranian chemists.

Research limitations/implications
The findings have implications for the planning of human resources in science. They could help maintain a stable scientific labor force and decide for instance whether a larger number of scientists should be trained and hired, or the barriers should be removed so the existing scientists can work for more years. The limitation is that the study is restricted to ISI articles, although they are not the only kind of scientific output.

Originality/value
This is the first study of its kind on Iranian scientific output. It shows that the overall labor force in the field of chemistry in Iran was not satisfactory, as the majority of authors in each period are transients. There is a need for better planning for the labor force.
Library performance evaluation in a dynamic environment using patron satisfaction
Authors: Zare Mehrjerdi Yahia 
Published: April 2017

Purpose
The purpose of this paper is to propose a new model for studying the patron’s satisfaction level over time for library systems. For this purpose, it is necessary to identify the key factors that are influential in nature. Thereafter, this paper explains and shows the procedure used for developing the causal loop diagram, the flow diagram, mathematical modelling and the simulation of the problem. A sample problem is used to show the applicability of the proposed model. Because the proposed methodology allows management to look into the patrons’ satisfaction level over time, it makes a significant contribution to the literature of the library and information management, as well as dynamic simulation modelling.

Design/methodology/approach
This paper is written based on the studies and observations from scientific journals and reports. For model development purposes, the author has used the concept of systems thinking and systems dynamics to model the complex systems and simulate that using Vensim computer simulation software.

Findings
As the trend of patron’s satisfaction shows, it is possible to improve the satisfaction level over time to a level above 60 per cent from 48 per cent over the simulation running periods. Meanwhile, the level of donation is up from 10 to 40 per cent in the same period as the satisfaction level has been studied. Because this is the first paper that looks into such important variables over time using systems dynamics, it makes significant contribution to the field of library and information management.

Originality/value
In almost all library models for patron’s satisfaction calculation, the proposed models are static and can find this value for a point of time rather than over a long period of time. In this paper, a system with an initial value of patron’s satisfaction level was used, and by taking all key factors into consideration, the author has developed a system that calculates patron’s satisfaction trend over time. Also, the proposed dynamic model is able to determine the level of donations that patrons can make to the library over time.
We should be just a number and we should embrace it
Authors: Kendall Graham , Yee Angelina , Hardy Steven 
Published: April 2017

Purpose
The purpose of this paper is to support the use of unique identifiers for the authors of scientific publications. This, the authors believe, aligns with the views of many others, as it would solve the problem of author disambiguation. If every researcher had a unique identifier, there would be significant opportunities to provide even more services. These extensions are proposed in this paper.

Design/methodology/approach
The authors discuss the bibliographic services that are currently available. This leads to a discussion of how these services could be developed and extended.

Findings
The authors suggest a number of ways that a unique identifier for scientific authors could support many other areas of importance to the scientific community. This will provide a much more robust system that provides a much richer and more easily maintained, scientific environment.

Originality/value
The scientific community lags behind most other communities with regard to the way it identifies individuals. Even if the current vision for a unique identifier for authors was to become more widespread, there would still be many areas where the community could improve its operations. This viewpoint paper suggests some of these, along with a financial model that could underpin the functionality.
Global research on information literacy: a bibliometric analysis from 2005 to 2014
Authors: Kolle Shankar Reddy 
Published: April 2017

Purpose
The purpose of this paper is to examine the literature published on information literacy (IL) from 2005 to 2014 and reveal the key aspects of IL publication trends.

Design/methodology/approach
The study analyses the literature indexed in Web of Science database on IL from 2005 to 2014 and used the required bibliometric measures to analyse specific aspects of publishing trends.

Findings
The findings of the study reveal that increase in literature on IL from 2005 to 2014 was noticed. A high amount of annual growth of literature on IL is observed for the year of 2007, 2008 and 2011. “Pinto, M” and the “University of Granada, Spain” was productive author and institute. Journal of Academic Librarianship was the most productive journal, with 97 articles being published for the period. USA was the most contributing country. “Digital divide”, “media literacy”, “pedagogy”, “higher education” and “critical thinking” were current research topics in the IL domain.

Originality/value
The paper is very useful for researchers to learn about trends in the literature on IL, as well as possible areas for further research, and it provides the names of the most productive authors, organizations and countries, along with the most popular IL keywords.
Digital preservation policies of the institutional repositories at Brazilian Federal Universities
Authors: da Silva Júnior Laerte Pereira , Manuel Borges Maria 
Published: April 2017

Purpose
This paper aims to verify the implementation of digital preservation policies at the institutional repositories (IRs) of Brazilian Federal Universities.

Design/methodology/approach
The methodology used involved the verification of the information available in the Directory of Open Access Repositories (OpenDOAR) and on the websites of the IRs, to confirm the existence of published digital preservation policies. In this study, a sample of the 26 IRs of Brazilian Federal Universities registered with OpenDOAR, which represents 68 per cent of these repositories, was used.

Findings
The main conclusion is that the IRs of these universities do not have any published digital preservation policies, even though some repositories state their intention of preserving digital material in their institutional information policy.

Originality/value
The stakeholders of IRs need to implement a programme to guide their activities to preserve digital materials in the long term. In fact, similar to examples worldwide, this programme should take the form of an institutional commitment outlined in a digital preservation policy. IRs at Brazilian Federal Universities still have a long way to go to guarantee access to digital materials in the long term.
Empowering academic librarians for effective e-services
Authors: Oyieke Lilian Ingutia , Dick Archie L. 
Published: April 2017

PurposeThe purpose of this paper was to assess the Web 2.0 competencies’ levels of academic librarians in selected libraries from two library consortia KLISC in Kenya and GAELIC in South Africa and how these competencies can be sources of empowerment for the effective provision of e-services. As service organizations, academic libraries face challenges similar to those in other service sectors. One of the major challenges includes that of providing not only quality print resources but also quality e-services. Globally, academic librarians use various Web 2.0 technologies to engage with their library users and colleagues and for their information work. Academic librarians are now, more than ever, expected to be empowered and build diverse voices, perspectives and arguments into library collections and services. Most of the youths (academic library users) in developing countries like Kenya and South Africa are heavy users of Web 2.0 technologies. This presents a challenge for their academic librarians who must augment their traditional library skills with Web 2.0 technologies for provision of effective e-services. This study explores the interconnections between librarian empowerment, traditional librarian skills and Web 2.0 competencies for effective e-services.Design/methodology/approachSurvey method of research was used to conduct the study. Purposive sampling was used to select a homogeneous sample of academic librarians and libraries that use the Web 2.0 technologies. An online questionnaire with both closed and open-ended questions was used to collect data. The Web 2.0 competency levels were analyzed and presented using descriptive statistics. To achieve more robust findings and to illustrate the implications of Web 2.0 for librarian empowerment, the ATLAS. ti software was used to illustrate interconnections between librarian empowerment, traditional librarian skills and Web 2.0 technologies. The emerging codes and themes are presented in three network views.FindingsThe findings from the quantitative data indicate that the majority of the librarians have intermediate competency levels in Web 2.0 technologies. The findings from the qualitative data show that Web 2.0 tools and librarian empowerment can be used to illustrate interconnections in content collaboration tools, bookmarking tools and SNSs. Web 2.0 competencies can transform knowledge-sharing activities, augment existing authoritative information service, foster interaction and market information products and services. This study redefines librarian empowerment through competency in Web 2.0 tools and new roles for effective e-services.Originality/valueThis paper proposes that librarian empowerment through Web 2.0 competencies is essential in augmenting traditional library skills and in providing effective e-services. This manuscript describes original work and is a re-submission EL-08-2015-0143.R1 due to expired deadline in this journal. Both authors approved the manuscript and this submission.
Analysis and forecast of Tianjin’s industrial energy consumption
Authors: Zhu Hongqing , Ge Xiaoling , Wang Yang , Ding Zequn 
Published: April 2017

Purpose
This paper aims to study the present situation of Tianjin industrial energy consumption carbon emissions and put forward constructive suggestions for future energy-saving emission reduction work.

Design/methodology/approach
Using the energy consumption data form the Tianjin’s Industrial Energy Efficiency Guide (TJBS, 2009-2013) and Tianjin’s Statistical Yearbook (NBS, 2006-2012), some models were able to predict the future with a high degree of accuracy.

Findings
With an average error of 3.06 per cent for the logistic regression model and an average error of 2.03 per cent for the gray model, the R2 for the energy elasticity model is 0.99158. It also indicated that between 2008 and 2012, the energy consumption per unit of industrial added value decreased by approximately 33.61 per cent. These results show that energy-saving efforts and the optimization of the industrial structure have increased the energy efficiency of Tianjin.

Originality/value
The authors think that their contribution refers to a combination between methodology of forecasting and industrial energy consumption.
Mobile assistive technology and the job fit of blind workers
Authors: Babu Rakesh , Heath Donald 
Published: April 2017

Purpose
This study aims to explore the potential of mobile assistive technology (MAT) as a vocational tool for blind workers (BW). Specifically, it investigates: Can MAT-enabled BW to perform better at the workplace and will insight into MAT-enabled capabilities impact employer perception regarding BW employability.

Design/methodology/approach
Exploratory case study which draws on theories of fit to analyze observational and interview data at an organization familiar with employing, training and referring BW.

Findings
MAT can increase blind worker job fit, positively impacting their performance, self-reliance and managerial perceptions regarding their employability.

Research limitations/implications
A conceptual framework is articulated which expands current literature on fit to better account for the assistive potential of mobile technology for differently abled workers.

Practical implications
The positive impact of MAT on managerial perceptions of BW fit and employability can inform the regimes of employers, job skills trainers, vocational rehabilitation specialists and policy makers.

Social implications
Insights on the use of MAT as a vocational tool can reduce the systemic workplace disenfranchisement of blind people.

Originality/value
This paper presents novel theory which accounts for the impact of MAT on the job fit of differently abled workers.