bluuebunny/crossref_metadata_2025_split huggingface dataset:
Information systems absorptive capacity for environmentally driven IS‐enabled transformation
Authors: Cooper Vanessa , Molla Alemayehu 
Published: April 2016

AbstractThe potential of information systems (IS) to enable environmental sustainability necessitates an understanding of how organisations can realise this potential. In this study, building on the absorptive capacity theory and following a multi‐disciplinary and multi‐method approach, we propose that developing IS‐environmental absorptive capacity is a significant mechanism to deliver IS‐enabled change that addresses environmental issues. We commenced with a literature review and exploratory interviews to define the IS‐environmental absorptive capacity construct. We then developed a model that proposes that sustainable IS triggers, knowledge exposure and prior experience influence IS‐environmental absorptive capacity, which in turn contributes to the level of environmentally sustainable IS assimilation as well as to the cost saving, operational performance and reputation of organisations. The model was first tested through an international survey of 148 senior IS managers. The findings support our model regarding the antecedents and value of IS‐environmental absorptive capacity. A follow‐up case study corroborated the survey results and provided additional insights into the nature and causes of IS‐environmental absorptive capacity and its value. This study, in addition to presenting empirical evidence, defines and operationalises the IS‐environmental absorptive capacity construct in a theoretically and operationally meaningful way.
Relationship between calving difficulty and fertility traits in first‐parity Iranian Holsteins under standard and recursive models
Authors: Mokhtari M.S. , Moradi Shahrbabak M. , Nejati Javaremi A. , Rosa G.J.M. 
Published: April 2016

SummaryThe main objective of this study was to estimate the genetic and phenotypic relationships between calving difficulty (CD) and fertility traits, including success at first service (SF), number of inseminations to conception (INS), interval from calving to first service (CTFS), interval between first and last service (IFL) and days open (DO), in first‐parity Iranian Holsteins under standard (SMMs) and recursive (RMMs) mixed models. The data analysed in this paper included 29 950 records on CD and fertility traits, collected in the time period from 1995 to 2014 by the Animal Breeding and Improvement Center of Iran. Under all observed SMMs and RMMs, five bivariate sire‐maternal grandsire models (ten bivariate analyses in total) were used for the analyses. Recursive models were applied with a view to consider that CD influences the fertility traits in the subsequent reproductive cycle and the genetic determination of CD and fertility traits by fitting CD as covariate for any of the fertility traits studied. The existence of such cause‐and‐effect is considered in RMMs but not in SMMs. Our results implied a statistically non‐zero magnitude of the causal relationships between CD and all the fertility traits studied, with the former influencing the latter. The causal effects of CD on SF (on the observed scale, %), INS, CTFS, IFL and DO were −2.23%, 0.10 services, 1.93 days, 3.76 days and 5.61 days, respectively. Direct genetic correlations between CD and the fertility traits under both models were not statistically different from zero (95% HPD interval included zero), except for the correlation between CD and CTFS, which were 0.197 and 0.134 under SMM and RMM, respectively, indicating that genes associated with difficult births also increase intervals between calving and the first insemination afterwards. Comparison of both models by the deviance information criterion (DIC) demonstrated the plausibility of RMMs over SMMs.
Accuracy of genomic prediction of purebreds for cross bred performance in pigs
Authors: Hidalgo A.M. , Bastiaansen J.W.M. , Lopes M.S. , Calus M.P.L. , de Koning D.J. 
Published: April 2016

SummaryIn pig breeding, as the final product is a cross bred (CB) animal, the goal is to increase the CB performance. This goal requires different strategies for the implementation of genomic selection from what is currently implemented in, for example dairy cattle breeding. A good strategy is to estimate marker effects on the basis of CB performance and subsequently use them to select pure bred (PB) breeding animals. The objective of our study was to assess empirically the predictive ability (accuracy) of direct genomic values of PB for CB performance across two traits using CB and PB genomic and phenotypic data. We studied three scenarios in which genetic merit was predicted within each population, and four scenarios where PB genetic merit for CB performance was predicted based on either CB or a PB training data. Accuracy of prediction of PB genetic merit for CB performance based on CB training data ranged from 0.23 to 0.27 for gestation length (GLE), whereas it ranged from 0.11 to 0.22 for total number of piglets born (TNB). When based on PB training data, it ranged from 0.35 to 0.55 for GLE and from 0.30 to 0.40 for TNB. Our results showed that it is possible to predict PB genetic merit for CB performance using CB training data, but predictive ability was lower than training using PB training data. This result is mainly due to the structure of our data, which had small‐to‐moderate size of the CB training data set, low relationship between the CB training and the PB validation populations, and a high genetic correlation (0.94 for GLE and 0.90 for TNB) between the studied traits in PB and CB individuals, thus favouring selection on the basis of PB data.
Fulminant type 1 diabetes mellitus with anti‐programmed cell death‐1 therapy
Authors: Okamoto Masahide , Okamoto Mitsuhiro , Gotoh Koro , Masaki Takayuki , Ozeki Yoshinori , Ando Hisae , Anai Manabu , Sato Asami , Yoshida Yuichi , Ueda So , Kakuma Tetsuya , Shibata Hirotaka 
Published: April 2016

AbstractAnti‐programmed cell death‐1 (PD‐1) antibodies are regarded as a risk factor for insulin‐dependent diabetes mellitus as a side‐effect. While a small number of cases have been reported, evidence remains limited. This is the first report of an Asian patient developing insulin‐dependent diabetes during anti‐PD‐1 therapy. A 55‐year‐old euglycemic woman receiving nivolumab for malignant melanoma showed abrupt onset of ketonuria, and elevated levels of plasma glucose (580 mg/dL) and hemoglobin A1c (7.0%). Over the next 2 weeks, serum C‐peptide levels fell below the limit of detection. Islet autoantibodies were negative, and the patient showed a human leukocyte antigen haplotype associated with type 1 diabetes. Anti‐PD‐1 therapy can cause rapid onset of insulin‐dependent diabetes, possibly because of inappropriate activation of T cells. Human leukocyte antigen haplotypes might be related to the onset of this disease. Physicians should be aware of this serious adverse event and carry out routine blood glucose testing during anti‐PD‐1 therapy.
Spatiotemporal fluctuations in natural selection acting on the gall‐parasitic aphid Tetraneura sorini
Authors: Muramatsu K. , Akimoto S. 
Published: April 2016

AbstractThe measurement of the selection gradient is crucial for understanding the magnitude of selection acting directly on a trait and predicting the evolutionary trajectory of that trait. This study evaluated the selection gradient acting on the morphology of the gall‐parasitic aphid Tetraneura sorini during the galling process and compared the strength among populations. Gall formers (first instars) frequently fight with conspecifics or heterospecifics for usurping incipient galls using their well‐developed hind legs. First instars that successfully acquired galls were found within galls, whereas those that failed were found dead on leaf surfaces. Selection gradients were estimated using logistic stepwise regression and partial least square (PLS) regression. Calculated selection differentials indicated that first instars that secured galls were larger in body size than failed individuals through all populations. However, selection gradients on weapon traits varied largely among populations or among years in the same population. We confirmed microevolutionary changes in the relationship between traits, which accorded with the expectation from changes in the selection gradients. When gall formers were transferred onto developing buds individually, individuals that successfully induced galls had smaller body size than failed individuals. Available evidence suggests that the selection gradient on body size becomes higher with an increasing proportion of T. sorini in the Tetraneura species community. Thus, we concluded that more intense fighting with conspecifics leads to stronger selective pressure on body size, but that selective pressure for each trait is variable depending on differences in the tactics and species composition among populations.
Effect of microscope parameter and specimen thickness of spatial resolution of transmission electron backscatter diffraction
Authors: WANG Y.Z. , KONG M.G. , LIU Z.W. , LIN C.C. , ZENG Y. 
Published: April 2016

SummaryThe spatial resolution of transmission electron backscatter diffraction (t‐EBSD) with a standard conventional EBSD detector was evaluated quantitatively based on the calculation of the correlation coefficient of transmission patterns which were acquired across a twin boundary in the sample of austenitic steel. The results showed that the resolution of t‐EBSD improved from tens of nanometres to below 10 nm with increasing accelerating voltage and thinning of specimen thickness. High voltage could enhance the penetration depth and reduce the scattering angle. And the thinning of specimen thickness would result in decreasing of the scattering events according to the theory of thermal diffuse scattering (TDS). In addition, the transmission patterns were found to be weak and noisy if the specimen was too thin, because of the decreasing intensity detected by the screen. Consequently, in this work, the best spatial resolution of 7 nm was achieved at 30 kV and 41 nm thickness. Moreover, the specimen thickness range was also discussed using Monte‐Carlo simulation. This approach was helpful to account for the differences of measured spatial resolutions, by t‐EBSD, of lamellas with different thickness.
Nuclear transport dysfunction: a common theme in amyotrophic lateral sclerosis and frontotemporal dementia
Authors: Jovičić Ana , Paul Joseph W. , Gitler Aaron D. 
Published: April 2016

AbstractAmyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases with overlapping genetic factors and pathology. On the cellular level, a majority of ALS and FTD cases are characterized by nuclear clearance and cytoplasmic aggregation of otherwise nuclear proteins, TAR DNA‐binding protein 43 (TDP‐43), or fused in sarcoma. Recent studies investigating cellular pathways perturbed by genetic risk factors for ALS/FTD converge on nucleocytoplasmic transport dysfunction as a mechanism leading to disease pathophysiology.
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We propose that mutations in FUS and hexanucleotide expansions in C9orf72 and aging all converge on the impairment of nucleocytoplasmic transport, which results in the hallmark pathological feature of ALS/FTD ‐ cytoplasmic aggregation of TDP‐43 or FUS.This article is part of the Frontotemporal Dementia special issue.
The Odyssey of Episodic Memories: Identifying the Paths and Processes Through Which They Contribute to Well‐Being
Authors: Philippe Frederick L. , Bernard‐Desrosiers Léa 
Published: April 2016

AbstractObjective:This research highlights the processes through which lasting episodic memories and their characterized level of need satisfaction (autonomy, competence, and relatedness) can impact well‐being, both at the situational level and over time.Method:Study 1 (N = 92, Mage = 42.07 years, 72% female) investigated the effect of the unconscious activation of a personal episodic memory on situational well‐being using a subliminal priming procedure. Study 2 (N = 275, Mage = 22.45 years, 84% female) followed the odyssey of an episodic memory by examining at various points over time its abstraction into perceptions of general need satisfaction and its long‐term effect on well‐being.Results:Study 1 revealed that the activation of a need‐satisfying memory produced an immediate increase in well‐being, whereas the triggering of a need‐thwarting memory led to an immediate decrease in well‐being compared to controls. Study 2 revealed little influence of individual differences, but need satisfaction in episodic memories had a significant cumulative impact on well‐being at different points in time over months and was abstracted into greater perceptions of general need satisfaction over time.Conclusion:Results provide convincing evidence for the directive function of memories on well‐being, both at the situational level and over time.
Identification of Aboriginal children using linked administrative data: Consequences for measuring inequalities
Authors: Gialamas Angela , Pilkington Rhiannon , Berry Jesia , Scalzi Daniel , Gibson Odette , Brown Alex , Lynch John 
Published: April 2016

AimThe aim of this study was to examine the identification of Aboriginal children in multiple administrative datasets and how this may affect estimates of health and development.MethodsData collections containing a question about Aboriginal ethnicity: birth registrations, perinatal statistics, Australian Early Development Census and school enrolments were linked to datasets recording developmental outcomes: national literacy and numeracy tests (National Assessment Program – Literacy and Numeracy), Australian Early Development Census and perinatal statistics (birthweight) for South Australian children born 1999–2005 (n = 13 414–44 989). Six algorithms to derive Aboriginal ethnicity were specified. The proportions of children thus quantified were compared for developmental outcomes, including those scoring above the national minimum standard in year 3 National Assessment Program – Literacy and Numeracy reading.ResultsThe proportion of Aboriginal children identified varied from 1.9% to 4.7% when the algorithm incremented from once to ever identified as Aboriginal, the latter using linked datasets. The estimates of developmental outcomes were altered: for example, the proportion of Aboriginal children who performed above the national minimum standard in year 3 reading increased by 12 percentage points when the algorithm incremented from once to ever identified as Aboriginal. Similar differences by identification algorithm were seen for all outcomes.ConclusionsThe proportion of South Australian children identified as Aboriginal in administrative datasets, and hence inequalities in developmental outcomes, varied depending on which and how many data sources were used. Linking multiple administrative datasets to determine the Aboriginal ethnicity of the child may be useful to inform policy, interventions, service delivery and how well we are closing developmental gaps.
Prospective evaluation of the safety of compounded bulk material L‐asparaginase in dogs with lymphoma
Authors: Thiman J. , Northrup N. , Saba C. , Clarke D. , Regan R. , Hamilton T. , Lindell H. , Hofmeister E. 
Published: April 2016

Use of compounded L‐asparaginase became routine in veterinary oncology when manufacturing of Elspar®was discontinued in 2012. The objective of this study was to evaluate the safety of compounded L‐asparaginase (CLASP,KRSGlobal Biotechnology, Boca Raton,FL,USA) in comparison with Elspar®(LundbeckLLC, Deerfield,IL,USA). In addition, we documented the response toCLASPin combination with a corticosteroid in this population of dogs with lymphoma. Dogs were prospectively treated with 10 000IU/m2CLASPor Elspar®subcutaneously. Corticosteroids were administered concurrently. Adverse events (AE) were assessed according to the Veterinary Cooperative Oncology Group Common Terminology Criteria for Adverse Events v1.1 (VCOG‐CTCAE). Response was recorded. Seventy‐three dogs received 75 treatments (CLASP,n = 47; Elspar®,n = 28). NoAEwere attributed toCLASP. Grade I andII AEprobably or possibly related to treatment were observed following two Elspar®treatments. The overall response rate to the combination ofCLASPand a corticosteroid was 80% (24%CRand 56%PR). In combination with a steroid, the compounded L‐asparaginase evaluated in this study is safe and demonstrates activity against canine lymphoma. In the face of the discontinuation of Elspar®, veterinarians should seek compounded LASP products that have been tested for activity, purity, and sterility.
The Gao‐Guenie impact melt breccia—Sampling a rapidly cooled impact melt dike on an H chondrite asteroid?
Authors: Schmieder Martin , Kring David A. , Swindle Timothy D. , Bond Jade C. , Moore Carleton B. 
Published: April 2016

AbstractThe Gao‐Guenie H5 chondrite that fell on Burkina Faso (March 1960) has portions that were impact‐melted on an H chondrite asteroid at ~300 Ma and, through later impact events in space, sent into an Earth‐crossing orbit. This article presents a petrographic and electron microprobe analysis of a representative sample of the Gao‐Guenie impact melt breccia consisting of a chondritic clast domain, quenched melt in contact with chondritic clasts, and an igneous‐textured impact melt domain. Olivine is predominantly Fo80–82. The clast domain contains low‐Ca pyroxene. Impact melt‐grown pyroxene is commonly zoned from low‐Ca pyroxene in cores to pigeonite and augite in rims. Metal–troilite orbs in the impact melt domain measure up to ~2 mm across. The cores of metal orbs in the impact melt domain contain ~7.9 wt% of Ni and are typically surrounded by taenite and Ni‐rich troilite. The metallography of metal–troilite droplets suggest a stage I cooling rate of order 10 °C s−1 for the superheated impact melt. The subsolidus stage II cooling rate for the impact melt breccia could not be determined directly, but was presumably fast. An analogy between the Ni rim gradients in metal of the Gao‐Guenie impact melt breccia and the impact‐melted H6 chondrite Orvinio suggests similar cooling rates, probably on the order of ~5000–40,000 °C yr−1. A simple model of conductive heat transfer shows that the Gao‐Guenie impact melt breccia may have formed in a melt injection dike ~0.5–5 m in width, generated during a sizeable impact event on the H chondrite parent asteroid.
The origins of I‐type spherules and the atmospheric entry of iron micrometeoroids
Authors: Genge Matthew J. 
Published: April 2016

AbstractThe Earth's extraterrestrial dust flux includes a wide variety of dust particles that include FeNi metallic grains. During their atmospheric entry iron micrometeoroids melt and oxidize to form cosmic spherules termed I‐type spherules. These particles are chemically resistant and readily collected by magnetic separation and are thus the most likely micrometeorites to be recovered from modern and ancient sediments. Understanding their behavior during atmospheric entry is crucial in constraining their abundance relative to other particle types and the nature of the zodiacal dust population at 1 AU. This article presents numerical simulations of the atmospheric entry heating of iron meteoroids to investigate the abundance and nature of these materials. The results indicate that iron micrometeoroids experience peak temperatures 300–800 K higher than silicate particles explaining the rarity of unmelted iron particles which can only be present at sizes of <50 μm. The lower evaporation rates of liquid iron oxide leads to greater survival of iron particles compared with silicates, which enhances their abundance among micrometeorites by a factor of 2. The abundance of I‐types is shown to be broadly consistent with the abundance and size of metal in ordinary chondrites and the current day flux of ordinary chondrite‐derived MMs arriving at Earth. Furthermore, carbonaceous asteroids and cometary dust are suggested to make negligible contributions to the I‐type spherule flux. Events involving such objects, therefore, cannot be recognized from I‐type spherule abundances in the geological record.
Toward a Theory of Negotiation Precedent
Authors: Crump Larry 
Published: April 2016

It is remarkable that precedents and their use have not been well explored within the negotiation literature. In this article, I examine the sparse knowledge of precedents and offer a preliminary framework for understanding the role of precedents in negotiation, including how negotiators establish and apply them. Precedents can either evolve randomly or be created with strategic intent. Understanding precedents generally involves examining how negotiators build, adopt, avoid, and reject them.In this review of the existing literature, I identify twelve concepts and paradigms that are particularly relevant to our understanding of negotiation precedents. I also establish a research agenda and identify three methods for further developing our knowledge of precedents: applying path dependence theory from the field of international relations to a negotiation context; conducting experimental research in a laboratory setting involving subjects engaged in negotiation exercises that contain opportunities to apply precedents; and conducting field research with a focus on case methodology grounded in negotiation linkage theory and theories of negotiation dynamics. Finally, in this article, I formulate a two‐part framework on building and applying precedents, and offer managerial guidance for the negotiation practitioner. Precedents serve as a strategic technique and provide a source of power at that point in a negotiation when decisions are made.
Somatic Mosaicism for a “Lethal” GJB2 Mutation Results in a Patterned Form of Spiny Hyperkeratosis without Eccrine Involvement
Authors: Eskin‐Schwartz Marina , Metzger Yoav , Peled Alon , Weissglas‐Volkov Daphna , Malchin Natalia , Gat Andrea , Vodo Dan , Mevorah Baruch , Shomron Noam , Sprecher Eli , Sarig Ofer 
Published: April 2016

AbstractBackgroundSpiny hyperkeratosis refers to a rare clinical phenotype characterized by nonfollicular keratotic projections and sometimes associated with other acquired and inherited conditions. We describe a case of congenital patterned spiny hyperkeratosis.MethodsTo identify the cause of this disorder, we used a combination of whole exome sequencing, direct sequencing and TaqMan assay.ResultsWe found that the peculiar clinical features displayed by the patient are due to somatic mosaicism for a heterozygous mutation in the GJB2 gene.ConclusionBecause histopathologic examination of two independent biopsies did not reveal porokeratotic eccrine ostial and dermal duct nevus (PEODDN), previously reported to result from somatic mutations in GJB2, it appears that mutations in this gene can cause nevoid spiny hyperkeratosis in the context of PEODDN or as an isolated finding.