bluuebunny/crossref_metadata_2025_split huggingface dataset:
A generic stochastic network-based formulation for production optimization of district heating systems
Authors: Guericke Daniela , Schledorn Amos , Madsen Henrik 
Published: September 2024

AbstractDistrict heating (DH) systems are an important component in the EU strategy to reach the emission goals, since they allow an efficient supply of heat while using the advantages of sector coupling between different energy carriers such as power, heat, gas and biomass. Most DH systems use several different types of units to produce heat for hundreds or thousands of households (e.g. natural gas-fired boilers, electric boilers, biomass-fired units, waste heat from industry, solar thermal units). Furthermore, combined heat and power units units are often included to use the synergy effects of excess heat from electricity production. To address the challenge of providing optimization tools for a vast variety of different system configurations, we propose a generic mixed-integer linear programming formulation for the operational production optimization in DH systems. The model is based on a network structure that can represent different system setups while the underlying model formulation stays the same. Therefore, the model can be used for most DH systems although they might use different combinations of technologies in different system layouts. The mathematical formulation is based on stochastic programming to account for the uncertainty of energy prices and production from non-dispatchable units such as waste heat and solar heat. Furthermore, the model is easily adaptable to different application cases in DH systems such as operational planning, bidding to electricity markets and long-term evaluation. We present results from three real cases in Denmark with different requirements.
Increased expression of IL-1β in adipose tissue in obesity influences the development of colon cancer by promoting inflammation
Authors: Neira Gabriela , Gómez-Ambrosi Javier , Cienfuegos Javier A. , Ramírez Beatriz , Becerril Sara , Rodríguez Amaia , Burrell María A. , Baixauli Jorge , Mentxaka Amaia , Casado Marcos , Silva Camilo , Escalada Javier , Frühbeck Gema , Catalán Victoria 
Published: September 2024

AbstractExcess adiposity contributes to the development of colon carcinoma (CC). Interleukin (IL)-1β is a pro-inflammatory cytokine relevant in obesity-associated chronic inflammation and tumorigenic processes. We herein aimed to study how obesity and CC affects the expression of IL1B, and to determine the impact of IL-1β on the regulation of metabolic inflammation and gut barrier function in the context of obesity and CC. Samples from 71 volunteers were used in a case–control study and a rat model of diet-induced obesity (DIO). Furthermore, bariatric surgery was used to determine the effect of weight loss on the intestinal gene expression levels of Il1b. To evaluate the effect of IL-1β and obesity in CC, we treated the adenocarcinoma cell line HT-29 with IL-1β and the adipocyte-conditioned medium (ACM) from patients with obesity. We showed that obesity (P < 0.05) and CC (P < 0.01) upregulated the transcript levels of IL1B in visceral adipose tissue as well as in the colon from patients with CC (P < 0.01). The increased expression of Il1b in the ileum and colon in DIO rats decreased after weight loss achieved by either sleeve gastrectomy or caloric restriction (both P < 0.05). ACM treatment on HT-29 cells upregulated (P < 0.05) the transcripts of IL1B and CCL2, while reducing (P < 0.05) the expression of the anti-inflammatory ADIPOQ and MUC2 genes. Additionally, IL-1β upregulated (P < 0.01) the expression of CCL2 and TNF whilst downregulating (P < 0.01) the transcript levels of IL4, ADIPOQ and TJP1 in HT-29 cells. We provide evidence of the important role of IL-1β in obesity-associated CC by directly promoting inflammation.
Destination and time-series inference of moving objects via conditionally Markov process
Authors: Lee Seokwon , Shin Hyo-Sang 
Published: September 2024

AbstractThis paper presents a destination and time-series inference algorithm for tracking moving targets. The destination of the object is considered the intent, and inference and state estimation are performed in the Bayesian framework. To describe the destination-aware target motion, we construct the state transition model using a conditionally Markov process. We introduce a multiple model to achieve simultaneous intent and time-series inferences. Given finite destination candidates, the maximum a posteriori hypothesis is chosen as the destination. For time-series inference, local estimates obtained from Kalman filters are fused to yield target state estimates. To address unspecified terminal conditions, the proposed algorithm incorporates parameter correction techniques based on relative geometry. Numerical simulations are performed to validate the proposed inference algorithm.
Effect of intraoperative hyperthermic intrathoracic chemotherapy after pleurectomy decortication for treatment of malignant pleural mesothelioma: a comparative study
Authors: Elsayed Hany Hasan , Sharkawy Hazem Youssef , Ahmed Mohammed Attia , Abdel-Gayed Mohammed , Eldewer Mostafa 
Published: September 2024

AbstractMalignant pleural mesothelioma (MPM) is an aggressive malignancy with few long-term survivors. Despite the dismal prognosis, hyperthermic intrathoracic chemoperfusion (HITOC) was shown to improve survival in a selective group of patients. We analyzed the influence of HITOC following pleurectomy and decortication on postoperative morbidity and overall survival for patients suffering from localized mesothelioma. From March 2017 until August 2023, 55 patients with localized pleural mesothelioma underwent pleurectomy and decortication. Thirty patients performed only surgery while 25 consecutive patients had surgery followed by HITOC with cisplatin (125 mg/m2) infused for 70 min at a temp of 40–43 °C. We analyzed postoperative morbidity, HITOC-related complications, and the influence of HITOC on survival. The trial was registered on 19/08/2022 as NCT05508555. The HITOC group had a mean age of 53.1 ± 8.2 years while the surgery group (non-HITOC) had a mean age of 52.1 ± 8.6 years. The HITOC group had 17 (68%) men, whereas the surgery group included 18 (60%) males. The 30-day mortality in the HITOC group was 0% vs 1 case (3.3%) in the surgery group. HITOC-related transient complications occurred in 4/25 (16%) of the HITOC group (atrial fibrillation, renal impairment and transient hypotension). Progression-free survival in the HITOC group was 8 months (95% CI 4.3–11.6) vs 6 months (95% CI 2.5–9.9) in the surgery-only group (p = 0.79). The overall survival time in the HITOC group was 28 months (95% CI 21.5–34.5) vs 22 months (95% CI 17.5–26.5) in the surgery-only group (p = 0.75). Risk factors analysis for recurrence in the HITOC group confirmed a significant role for early stages (p = 0.03). HITOC following pleurectomy and decortication is a safe therapeutic option that may improve survival for selected patients with localized epithelial pleural mesothelioma. Patients with earlier-stage mesothelioma are more likely to benefit from radical surgery and HITOC.
QTL analysis of sorghum grain traits based on high-density genetic map
Authors: Cao Ning , Ding Yanqing , Xu Jianxia , Cheng Bin , Gao Xu , Li Wenzhen , Zou Guihua , Zhang Liyi 
Published: September 2024

AbstractSorghum grain traits are important agronomic traits directly related to yield and are key factors affecting the brewing process of distill liquor. Exploring the genes controlling those traits is of great significance for understanding the genetic mechanism of sorghum grain development. In this study, we conducted genotyping using Super-GBS technology on a recombinant inbred lines (RILs) population derived from the cross between “BTx623” and “Hongyingzi,” consisting of 205 lines. The grain-related traits of the RIL population were investigated in Guiyang, Anshun in Guizhou, and Ledong in Hainan in China. By inclusive composite interval mapping (ICIM) method, a total of 47 quantitative trait locus (QTL) related to four grain traits (thousand grain weight, grain length, grain width, and length–width ratio) were identified across 10 chromosomes. Among them, 20 important QTL were repeatedly detected in multiple traits or environments and distributed on chromosomes 1 (1), 2 (2), 3 (5), 4 (5), 5 (1), 6 (2), 7 (2), 8 (1), and 9 (1). Six candidate genes were identified within the confidence interval of these QTL, and they are homologous to genes controlling rice grain development (OsMADS1, RGG2, OsNST1, SMG1, OsGRF8, and OsAP2-39). The results provide a basis for further cloning and functional verification of these candidate genes.
Morphological characterization of two dermal and hypodermal alterations in an adult man: surgical scar vs. stretch mark
Authors: Veronese Sheila , Picelli Alessandro , Zoccatelli Andrea , Amuso Domenico , Amore Roberto , Smania Nicola , Frisone Alessio , Sbarbati Andrea , Scarano Antonio 
Published: September 2024

AbstractScars and stretch marks are extremely common. For scars, evidence of alterations of the dermal and hypodermic layers is known, while for stretch marks, less data are available, and they are considered purely aesthetic conditions. The intra- and inter-subject variability of the skin makes the comparison between these two particularly complex. This study presents the case of a 54-year-old man who had both stretch marks and a surgical scar on his abdomen. We performed ultrasound and elastosonographic investigations for both to analyse the structural alteration of the skin and subcutaneous layers. Their structures were also compared to the structure of intact skin. The two skin conditions appeared substantially morphologically different and different from intact skin. The alterations detected, particularly of the connective structures, allow us to state that both scars and stretch marks are alterations of both the dermis and the hypodermis and stretch marks differ from scars.
Relacorilant or surgery improved hemostatic markers in Cushing syndrome
Authors: Simeoli C. , Di Paola N. , Stigliano A. , Lardo P. , Kearney T. , Mezosi E. , Ghigo E. , Giordano R. , Mariash C. N. , Donegan D. M. , Feelders R. A. , Hand A. L. , Araque K. A. , Moraitis A. G. , Pivonello R. 
Published: September 2024

Abstract
Purpose
Glucocorticoid-mediated hypercoagulability can persist in patients with endogenous Cushing syndrome (CS) after curative surgery and may transiently worsen early postoperatively. These studies aimed to characterize coagulation markers at baseline in patients with CS and the impact of relacorilant or remission post-surgery in an open-label, phase 2 study (NCT02804750) and a retrospective, longitudinal, surgical cohort study.

Methods
In the relacorilant study, 34 patients received relacorilant (100–200 mg/day for up to 12 weeks or 250–400 mg/day for up to 16 weeks) and had postbaseline data. Coagulation markers were assessed before and during treatment. In the surgical study, conducted at “Federico II” University of Naples, Italy, coagulation markers were assessed in 30 patients before surgery and after biochemical remission.

Results
In the relacorilant study, significant mean changes from baseline to last observed visit were reported in factor VIII (− 18.9%, P = 0.022), activated partial thromboplastin time (aPTT) (+ 1.5 s, P = 0.046), and platelet count (− 68.8*109/L, P < 0.0001), whereas von Willebrand factor was unchanged. In the surgical study, the mean time to hemostasis assessment was 6.2 months. Significant mean changes from baseline to hemostasis assessment were reported in factor VIII (− 24.2%, P = 0.044), von Willebrand factor (− 20.6%, P = 0.018), and aPTT (+ 2.0 s, P = 0.031), whereas platelet count was unchanged.

Conclusions
Several coagulation markers improved in patients with CS after 3–4 months of relacorilant treatment and within an average of 6 months after surgery. Relacorilant’s positive effects on coagulation markers support further investigation of its use preoperatively in patients with CS or in patients who are not eligible for surgery.

Clinical Trial Registration Number
NCT0280475 (registration date: 15 June 2016).
Bid-Aggregation Based Clearing of Day-Ahead Electricity Markets
Authors: Feczkó Botond , Divényi Dániel , Sleisz Ádám , Csercsik Dávid 
Published: September 2024

AbstractIn this work we propose a heuristic clearing method for a simplified model of European day-ahead electricity auction markets, considering divisible standard bids and block orders. In the first part of the process, a computationally less demanding problem is solved using an approximation of the cumulative demand and supply curves, which are derived via the aggregation of simple bids. Based on the outcome of this problem, estimated ranges for the clearing prices of individual periods are determined. In the final step, the clearing for the original bid set is solved, taking into account the price ranges determined previously as constraints, reducing the feasibility region of the clearing problem. By removing bids whose acceptance or rejection is already determined by the assumed price range constraints, the size of the problem is also significantly reduced. Via simple examples, we show that due to the possible paradox rejection of block orders the proposed bid-aggregation based approach may result in a suboptimal solution or in an infeasible problem, but we also point out that these pitfalls of the algorithm may be avoided by using different aggregation patterns. We propose to run multiple threads of the algorithm, using different aggregation patterns. We evaluate the performance of the algorithm via numerical tests.
Survival Outcomes of Metastatic or Recurrent Cervical Cancer Patients Treated with Palliative Intent Chemotherapy: Real-World Data
Authors: Rath Sushmita , Elamarthi Prahalad , Ghosh Jaya , Gulia Seema , Bajpai Jyoti , Mittal Prachi , Gurram Lavanya , Kulkarni Rohini , Dash Biswajit , Rekhi Bharat , Menon Santosh , Deodhar Kedar , Baheti Akshay , Sable Nilesh , Popat Palak , Maheshwari Amita , Chopra Supriya , Gupta Sudeep 
Published: September 2024

Abstract
Objective
To analyse the outcomes of metastatic or recurrent cervical cancer patients treated with palliative intent chemotherapy, as data on their outcomes are scant from LMIC.

Methods
In this retrospective analysis, 302 upfront metastatic or recurrent cervical cancer patients were treated with palliative intent from 1 January 2015 till 31 March 2020. The demographics, palliative therapy details, progression-free survival (PFS) and overall—survival (OS) were analysed for those receiving chemotherapy.

Results
The median age was 53 (IQR 48-61) years and 248, (82.0 %) patients belonged to low-socioeconomic strata. Most common histology was squamous cell carcinoma (SCC) in 263 (87.1%) patients. De novo metastatic disease was seen in 119 (39.4 %) and recurrence post-treatment was seen in 183 (60.6 %) patients. Among the 302 patients, 149 (49.3%) patients received palliative chemotherapy, 70 (23.2 %) received palliative radiotherapy and 83 (27.5%) patients were considered for palliative care alone. The most common regimen was paclitaxel and carboplatin in 124 (83.2 %) patients. Eighty (53.7 %) patients completed 6 cycles. Four (2.7 %) received bevacizumab with chemotherapy in the first line and 3 (2.0%) patients received pembrolizumab in second line. The median PFS was 8.5 months (95% CI: 7.12–9.89 months) and median OS was 13.0 months (95% CI: 11.10–14.98 months) with median duration of follow-up of 33.4 months (range 27.9–38.9 months).

Conclusions
In real-world scenario, only half of the metastatic or recurrent cervical patients received any palliative chemotherapy. Paclitaxel and carboplatin are an effective regimen, and there was limited access to targeted therapy and immunotherapy.
Stone Tools in Shifting Sands: Past, Present, and Future Perspectives on the Châtelperronian Stone Tool Industry
Authors: Djakovic Igor , Roussel Morgan , Soressi Marie 
Published: September 2024

Abstract
The Middle to Upper Palaeolithic transition in France and northern Spain reflects the transition from Neandertals to Homo sapiens and the emergence of novel cultural entities and standardised blade and bladelet technologies between ~ 55 and 40 thousand years ago. The Châtelperronian stone tool industry represents the first unambiguous appearance of Upper Palaeolithic technologies in this region, and is traditionally considered as representing a geographically isolated archaeological entity produced by late Neandertals. However, debate as to the makers and origin of this industry has been ever-present. In recent years, fuel has been thrown onto this discussion through (a) the demonstration that the association between Neandertal remains and Châtelperronian artefacts at the key site of Saint-Césaire could not be reliable, (b) the identification of an immature Homo sapiens pelvic fragment in association with Neandertal remains and Châtelperronian artefacts at the Grotte du Renne (Arcy-sur-Cure), and (c) the formulation of a disruptive hypothesis in which the Châtelperronian directly originates from the Early Upper Palaeolithic of the Levant. In conjunction with the increasing evidence for a protracted presence of Homo sapiens across Europe, these observations have led to the arrival of an inflection point for the competing interpretations concerning the origin and implications of this industry. In this paper, we provide a critical review of the Châtelperronian in light of the emerging data—taking into account technological, chronological, geographic, stratigraphic, and genetic perspectives. First we provide a detailed, three-part historiography of this industry and a modern, synthetic review of Châtelperronian lithic technology. Our review reinforces the fact that the Châtelperronian is a fully Upper Palaeolithic industry with no ‘transitional’ nor Initial Upper Palaeolithic-type technological features. Subsequently, we highlight a series of prospects, problems, and uncertainties which remain to be addressed in discussions concerning the origins, maker(s), and implications of the Châtelperronian and the onset of the Upper Palaeolithic in western Europe. Finally, we propose a few potential paths forward and call for an open and critical approach towards the re-conceptualisation of the Châtelperronian in the years to come.
Towards a taxonomy of team workflow structures
Authors: Fitzhugh Sean M. 
Published: September 2024

AbstractTeam workflow represents interactions between individuals and specific actions or tasks. Individuals’ interactions have important effects on fellow teammates’ actions by expanding or constraining actions available to them. For example, teammates may avoid performing the same action to avoid duplication of effort or they may perform their actions sequentially if one task’s completion is a prerequisite for another task. Complex dependencies embedded in these interactions suggest the need to understand team workflows from a relational perspective. As workflow structures are shaped by elements of organizational design, cognitive factors, and features of the task environment, no single workflow structure is optimal for all teams, and team workflows may manifest in countless distinct configurations. Through a systematic, network-based representation of team workflows, this paper uses a sample of 139,500 teams on GitHub to identify common patterns of team workflows. Each team is represented as a two-mode network where individuals form ties to up to fifteen distinct actions capturing productivity, discussion, and team management. Several node-level and graph-level centrality indices highlight patterns of differentiation across team workflows, and a k-means clustering algorithm detects three distinct clusters of team workflow structures: small teams of highly active generalists, small teams with a moderately active mix of focused and generalist members, and large, segmented teams of focused individuals collectively engaging in a few extremely popular actions. These results demonstrate how a structural representation of team workflows provides unique insight into team behavior and highlights distinctions that may otherwise be lost when examining team activity in aggregate.
Regional ecosophy: a Guattarian approach to the border landscapes of the Irish Northwest
Authors: Doherty Gareth , Fité Matamoros Pol 
Published: September 2024

AbstractIn this paper, we propose that landscape architecture is uniquely equipped to shape highly contested and politicized border regions. We contend that recognizing landscape architecture’s agency to contribute to national and international politics may enable the field to intervene in contemporary theoretical discussions within urban and regional studies that are otherwise dominated by geography and urban planning. Through the example of the Irish/Northern Irish border region in the face of Brexit, we discuss the limits to city planning and policy designations—such as that of city-region—in addressing the complex economies and ecologies of similar geopolitical landscapes. We also highlight environmentalist planning and design’s limitations in addressing the complex social practices and subjectivities that weave together regions like the Irish Northwest. Our alternative is a fieldwork-based “ecosophical” approach capable of addressing Félix Guattari’s social, environmental, and subjective ecologies in an integrated manner. With this, we establish how such an approach can offer a more nuanced set of tools to design and plan for larger regional landscapes.
Sunward Oxygen Ion Fluxes and the Magnetic Field Topology at Mars From Hybrid Simulations
Authors: Dubinin E. , Modolo R. , Leblanc F. , Pätzold M. , Romanelli N. 
Published: September 2024

AbstractIt is commonly believed that because of the direct solar wind interaction with the Martian atmosphere/ionosphere, the planet could have lost a significant part of its atmosphere. Closed field lines of the crustal magnetic field can weaken a transport of the ionospheric ions to the tail. Reconnection of the interplanetary magnetic field lines draping around Mars and the crustal magnetic field can also lead to a presense of sunward fluxes of planetary ions that might affect the total ion loss. The LatHyS (LATMOS Hybrid Simulation) three‐dimensional multispecies hybrid model is used here to characterize sunward fluxes of O+ ions and the magnetic field topology at Mars. It is shown that although reconnection between the interplanetary magnetic field (IMF) and the crustal magnetic fields strongly modifies the field topology, then sunward ion fluxes are rather small and do not significantly change the total ion loss.
Physics‐Based Forecasts of Eruptive Vent Locations at Calderas
Authors: Mantiloni L. , Rivalta E. , Anderson K. R. , Davis T. , Passarelli L. 
Published: September 2024

AbstractConstraining stresses in the Earth's crust in volcanic regions is critical for understanding many mechanical processes related to eruptive activity. Dike pathways, in particular, are shaped by the orientation of principal stress axes. Therefore, accurate models of dike trajectories and future vent locations rely on accurate estimates of stresses in the subsurface. This work presents a framework for probabilistic constraint of the stress state of calderas by combining three‐dimensional physics‐based dike pathway models with observed past vent locations using a Monte Carlo approach. The retrieved stress state is then used to produce probability maps of future vent opening across a caldera. We test our stress inversion and vent forecast approach on synthetic scenarios, and find it successful depending on the distribution of the available vents and the complexity of the volcano's structural history. We explore the potential and limitations of the approach, show how its performance is sensitive to the assumptions in the models and available prior information, and discuss how it may be applied to real calderas.