bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studies on the antioxidant properties of some phytoestrogens
Authors: Kładna Aleksandra , Berczyński Paweł , Kruk Irena , Piechowska Teresa , Aboul‐Enein Hassan Y. 
Published: January 2016

AbstractIsoflavones genistein and daidzein are nonsteroidal phytoestrogens occurring mainly in soybean foods. These phytoestrogens possess estrogenic properties and show a variety of health benefits as anti‐inflammatory agents. However, the mechanism of their action has not been identified in detail. The aim of this study is to characterize the antioxidant powers of genistein, daidzein and daidzein metabolite–equol through their activities to scavenge superoxide anion radical (O•2−), hydroxyl radical (HO•), 2,2–diphenyl–1‐picrylhydrazyl radical (DPPH•) and hydrogen peroxide (H2O2) using chemiluminescence and spectrophotometry techniques. Potassium superoxide in dimethyl sulphoxide (DMSO) and 18‐crown‐6 ether were used as a source of O•2−. Hydroxyl radicals were produced using the Fenton reaction. In free radical assays, genistein had the IC50 values (an amount of antioxidant concentration required to decrease the initial radical concentration by 50%) 0.391 ± 0.012 mM for O•2−, 0.621 ± 0.028 mM for HO• and 1.89 ± 0.16 mM for DPPH•. The IC50 values for daidzein for these free radicals were 1.924 ± 0.011 mM, 0.702 ± 0.012 mM and 2.81 ± 0.03 mM, respectively. Equol was the most active the free radical scavenger with IC50 = 0.451 ± 0.018 mM for HO• and IC50 = 1.36 ± 0.11 mM for DPPH•. All tested compounds exerted a significant effect on the H2O2: IC50 = 18.1 ± 1.1 μM for genistein, IC50 = 2.1 ± 0.5 μM for daidzein, and IC50 = 1.06 ± 0.2 μM for equol. These findings show that genistein, daidzein and equol are effective free radical scavengers and possess high antioxidant power in vitro. Copyright © 2016 John Wiley & Sons, Ltd.
Involvement of autophagy in the procedure of endoplasmic reticulum stress introduced apoptosis in bone marrow mesenchymal stem cells from nonobese diabetic mice
Authors: Meng Yan , Ji Juan , Tan Wei , Guo Genkai , Xia Yunfei , Cheng Chun , Gu Zhifeng , Wang Zhiwei 
Published: January 2016

Recent studies showed that bone marrow mesenchymal stem cells (BM‐MSCs) from nonobese diabetic (NOD) mice exhibited the phenomenon of apoptosis. However, the mechanisms of apoptosis remained largely unknown. In this study, endoplasmic reticulum (ER) stress and autophagy were evidenced in BM‐MSCs from NOD mice for the first time. We found the ER stress‐mediated apoptosis was supported by the up‐regulation of ER stress markers including augmented phosphorylation of phosphorylated protein kinase RNA‐like ER kinase and eukaryotic translation initiator factor 2α as well as cleavage of caspase‐3. Evidence of autophagy included the formation of the acidic vesicular organelles and increase of LC3 accumulation. Intriguingly, blockage of ER stress could reduce the apoptosis of BM‐MSCs from NOD mice and alleviated accumulation of LC3, which indicated that ER stress induced apoptosis and autophagy. Furthermore, our results showed that the mechanism of ER stress‐induced autophagy was associated with the decrease of p‐S6 (a marker of mTOR activity). Here, we demonstrated that ER stress‐induced cell death was mediated by autophagy that was partly attributed to the inactivation of the mammalian target of rapamycin.Significance ParagraphWe report for the first time that endoplasmic reticulum (ER) stress mediated apoptosis of bone marrow mesenchymal stem cells (BM‐MSCs) from nonobese diabetic (NOD) mice. The evidence of autophagy was also found in BM‐MSCs from NOD mice, included the formation of the acidic vesicular organelles and increase of LC3 accumulation. Furthermore, we demonstrated that ER stress‐induced cell death was mediated by autophagy that was partly attributed to the inactivation of the mammalian target of rapamycin. Deciphering the mechanisms of ER stress signalling involved in the apoptosis of BM‐MSCs from NOD mice will help improve transplantation efficacy of BM‐MSCs in type 1 diabetes patients. Copyright © 2016 John Wiley & Sons, Ltd.
Urinary retention secondary to acute vasculitic penile swelling in a pediatric patient
Authors: Farkas Nicholas , Black John , Gupta Ashish 
Published: January 2016

Key Clinical MessageAcute urinary retention secondary to vasculitic penile swelling in children is extremely rare. Henoch–Schönlein purpura is a self‐limiting IgA‐mediated cutaneous vasculitis, which can cause soft tissue edema. Acute urinary retention requires urgent intervention to prevent obstructive uropathy. Suprapubic catheterization provides an effective management strategy in the emergency setting.
ChemInform Abstract: Blue‐Emitting Sr3Si8‐xAlxO7+xN8‐x :Eu2+ Discovered by a Single‐Particle‐Diagnosis Approach: Crystal Structure, Luminescence, Scale‐Up Synthesis, and Its Abnormal Thermal Quenching Behavior.
Authors: Wang Xiao‐Jun , Wang Le , Takeda Takashi , Funahashi Shiro , Suehiro Takayuki , Hirosaki Naoto , Xie Rong‐Jun 
Published: January 2016

AbstractSr3Si8‐xAlxO7+xN8‐x :Eu2+ (x = 1.5—3.5) phosphor powders are prepared by firing appropriate amounts of SrCO3, Si3N4, SiO2, AlN, and Eu2O3 (1 MPa N2, 1500 °C, 2 h).
ChemInform Abstract: Phase Behavior in the LiBH4—LiBr System and Structure of the Anion‐Stabilized Fast Ionic, High Temperature Phase.
Authors: Cascallana‐Matias Irene , Keen David A. , Cussen Edmund J. , Gregory Duncan H. 
Published: January 2016

AbstractPolycrystalline samples of Li(BH4)1‐xBrx are prepared from appropriate mixtures of LiBH4 and LiBr by both intermittent ball milling (24 h, 2 min breaks) alone and ball milling (4 h) followed by annealing (573 K, 5‐24 h).
ChemInform Abstract: Sm3S3BO3: The First Sulfide Borate Without S—O and B—S Bonds.
Authors: Guo Sheng‐Ping , Chi Yang , Xue Huai‐Guo 
Published: January 2016

AbstractSm3S3BO3 is obtained via solid‐state reaction of a 3:1:3 molar mixture of Sm2O3, B, and S (evacuated quartz tubes, staged heating at 300—950 °C, 5 h/stage, 10 d; cooling to 300 °C within 5 d).
ChemInform Abstract: A Terbium Rich Orthoborate LiSrTb2(BO3)3 and its Analogues.
Authors: Chen Pengyun , Xia Mingjun , Li R. K. 
Published: January 2016

AbstractSingle crystals of LiSrTb2(BO3)3 are grown by heating a 1:12:12:6 molar mixture of Tb4O7, SrCO3, H3BO3, and Li2CO3 (Pt crucible, 950 °C, 1 d; cooling to 500 °C at a rate of 1.5 °C/h).
ChemInform Abstract: Enantioselective ortho‐C—H Cross‐Coupling of Diarylmethylamines with Organoborons.
Authors: Laforteza Brian N. , Chan Kelvin S. L. , Yu Jin‐Quan 
Published: January 2016

AbstractThis method exploits the synthetically practical and easily deprotected para‐nitrobenzenesulfonamide as a directing group and a chiral mono‐N‐protected amino acid ligand (FLE) is used as promoter.
ChemInform Abstract: Rhodium(I)‐Catalyzed [2 + 2 + 2] Cycloaddition Between Allene, Alkyne, and Imine via a Strained Azarhodacycle Intermediate.
Authors: Oonishi Yoshihiro , Hato Yoshio , Sato Yoshihiro 
Published: January 2016

AbstractThe new cyclization reaction proceeds via a strained azarhodacycle, giving a 5,7‐fused cyclic amide or a tricyclic product containing an 8‐azabicyclo[3.2.1]octane skeleton in high yield.
ChemInform Abstract: Platinum(IV)‐Catalyzed Synthesis of Unsymmetrical Polysubstituted Benzenes via Intramolecular Cycloaromatization Reaction.
Authors: Zheng Shuyan , Zhang Jinghua , Shen Zhengwu 
Published: January 2016

AbstractThe Pt‐catalyzed intramolecular cycloaromatization of enynes (I) and (III) proceeds via a tandem skeletal rearrangement, dehydration, and double bond isomerization to afford polysubstituted benzenes (II) and (IV).
ChemInform Abstract: [2 + 2] Photocycloaddition of Cinnamates in Flow and Development of a Thiourea Catalyst.
Authors: Telmesani Reem , Park Sung H. , Lynch‐Colameta Tessa , Beeler Aaron B. 
Published: January 2016

AbstractThe bis(thiourea)‐catalyzed dimerization of cinnamates (I) in a flow photoreactor gives rise to diaryl‐cyclobutanedicarboxylates as a mixture of diastereomers (II) and (III).
ChemInform Abstract: Palladium(II)‐Catalyzed Allylic C—H Oxidation of Hindered Substrates Featuring Tunable Selectivity over Extent of Oxidation.
Authors: Xing Xiangyou , O'Connor Nicholas R. , Stoltz Brian M. 
Published: January 2016

AbstractDepending on the presence or absence of water a two‐electron oxidation to the allylic acetates or a four‐electron oxidation to the corresponding enals takes place.
ChemInform Abstract: Visible‐Light‐Induced Photocatalytic Trifluoromethylation/1,2‐Carbon Migration Sequences for the Synthesis of CF3‐Substituted Cyclic Ketones.
Authors: Woo Saet Byeol , Kim Dae Young 
Published: January 2016

AbstractCF3‐Substituted ketones [(III), (V), (VII), (IX), and (XI)] are conveniently synthesized via title reaction sequence induced by blue light irradiation under mild reaction conditions.
ChemInform Abstract: Cu‐Catalyzed Cyanation of Arylboronic Acids with Acetonitrile: A Dual Role of TEMPO.
Authors: Zhu Yamin , Li Linyi , Shen Zengming 
Published: January 2016

AbstractMechanistic studies indicate that a TEMPO‐CH2CN species, generated in situ, is the active, highly reactive cyanating agent.
ChemInform Abstract: Copper‐Mediated One‐Pot Synthesis of Trifluorostyrene Derivatives from Tetrafluoroethylene and Arylboronate.
Authors: Kikushima Kotaro , Sakaguchi Hironobu , Saijo Hiroki , Ohashi Masato , Ogoshi Sensuke 
Published: January 2016

AbstractA copper‐mediated synthesis of trifluorostyrene derivatives is developed.
ChemInform Abstract: A Mild and General One‐Pot Synthesis of Densely Functionalized Diaryliodonium Salts.
Authors: Qin Linlin , Hu Bao , Neumann Kiel D. , Linstad Ethan J. , McCauley Katelyenn , Veness Jordan , Kempinger Jayson J. , DiMagno Stephen G. 
Published: January 2016

AbstractA scalable synthesis is presented which gives access to a wide range of very densely functionalized diaryliodonium salts from aryl iodides under mild conditions.
ChemInform Abstract: Hypervalent Iodine(III) in Direct Oxidative Amination of Arenes with Heteroaromatic Amines.
Authors: Manna Srimanta , Serebrennikova Polina O. , Utepova Irina A. , Antonchick Andrey P. , Chupakhin Oleg N. 
Published: January 2016

AbstractThe title reaction amination applies to electron‐rich arenes and amino derivatives of electron‐deficient heterocycles.
ChemInform Abstract: A Highly Efficient Heterogeneous Aerobic Alcohol Oxidation Catalyzed by Immobilization of Bipyridine Copper(I) Complex in MCM‐41.
Authors: Zhao Hong , Chen Qiurong , Wei Li , Jiang Yuanyuan , Cai Mingzhong 
Published: January 2016

AbstractA novel MCM‐41‐immobilized bipyridine copper(I) complex is synthesized and used for the aerobic oxidation of primary benzylic and allylic alcohols to aldehydes.The catalyst is reusable for at least 10 consecutive runs without significant loss of activity.
ChemInform Abstract: Synthesis of α‐Alkylated Ketones via Tandem Acceptorless Dehydrogenation/α‐Alkylation from Secondary and Primary Alcohols Catalyzed by Metal—Ligand Bifunctional Iridium Complex [Cp*Ir(2,2′‐bpyO)(H2O)].
Authors: Wang Rongzhou , Ma Juan , Li Feng 
Published: January 2016

AbstractCompared to previous methods, the new strategy leads completely selectively to α‐alkylated ketones under more environmentally benign conditions.
ChemInform Abstract: ortho‐C—H Benzylation of Aryl Imines with Benzyl Phosphates under Cobalt—Pyphos Catalysis.
Authors: Xu Wengang , Paira Rupankar , Yoshikai Naohiko 
Published: January 2016

AbstractAryl and hetaryl imines as well as imines derived from 4‐chromanone and 1‐tetralone are ortho‐benzylated in a scalable manner with variously substituted benzylic phosphonates and diphosphonates.
ChemInform Abstract: Copper‐Catalyzed Diazo Cross‐/Homo‐Coupling Toward Tetrasubstituted Olefins and Applications on the Synthesis of Maleimide Derivatives.
Authors: Zhu Chenghao , Xu Guangyang , Ding Dong , Qiu Lin , Sun Jiangtao 
Published: January 2016

AbstractThe method allows for the preparation of symmetric and unsymmetric diaryl as well as arylalkyl substituted biscarboxylated olefins which are obtained with high to excellent Z‐selectivity.
ChemInform Abstract: Highly Diastereoselective Synthesis of Spirocyclopropane‐Oxindoles Using InCl3 as a Catalyst in Water.
Authors: Muthusamy Sengodagounder , Ramkumar Rajagopal 
Published: January 2016

Abstract1‐Alkyl‐3‐diazoindol‐2‐ones react with chalcones, dimethyl fumarate, or methyl acrylate providing the title compounds in good yields with remarkable diastereoselectivities and regioselectivities in the case of unsymmetrically substituted chalcones.
ChemInform Abstract: Chemical Fixation of CO2 into Cyclic Carbonates by Azo‐Containing Schiff Base Metal Complexes.
Authors: Ikiz Mesut , Ispir Esin , Aytar Emine , Ulusoy Mahmut , Karabuga Semistan , Aslantas Mehmet , Celik Oemer 
Published: January 2016

AbstractTwo new ligands containing a ‐N=N‐ group and their metal complexes are synthesized and examined as catalysts for the synthesis of cyclic carbonates starting from epoxides with CO2.
ChemInform Abstract: Y(OTf)3‐Catalyzed Cascade Propargylic Substitution/Aza‐Meyer—Schuster Rearrangement: Stereoselective Synthesis of α,β‐Unsaturated Hydrazones and Their Conversion into Pyrazoles.
Authors: Liu Wenfei , Wang Han , Zhao Haiying , Li Baoguo , Chen Shufeng 
Published: January 2016

AbstractTitle reaction may also be embedded in a 3‐step sequence to the respective pyrroles starting from aceto‐ or benzophenone and phenylacetylene.
ChemInform Abstract: Green Synthesis of Tri/Tetrasubstituted 1H‐Imidazoles and 2,3‐Dihydroquinazolin‐4(1H)‐ones Using Nano Aluminum Nitride as Solid Source of Ammonia.
Authors: Hajjami Maryam , Ghorbani‐Choghamarani Arash , Yousofvand Zakieh , Norouzi Masoomeh 
Published: January 2016

AbstractA simple, green, and cost‐effective protocol is achieved for the synthesis of tri‐ and tetrasubstituted imidazoles and pyrimidine derivatives using nano aluminium nitride as a solid source of ammonia.
ChemInform Abstract: Base‐Mediated Syntheses of Di‐ and Trisubstituted Imidazoles from Amidine Hydrochlorides and Bromoacetylenes.
Authors: Chen Xiao Yun , Englert Ulli , Bolm Carsten 
Published: January 2016

AbstractA new transition metal‐free method for the preparation of title compounds (III), (V) and (VII) is reported.
ChemInform Abstract: Imidazoles from Nitroallylic Acetates and α‐Bromonitroalkenes with Amidines: Synthesis and Trypanocidal Activity Studies.
Authors: Gopi Elumalai , Kumar Tarun , Menna‐Barreto Rubem F. S. , Valenca Wagner O. , da Silva Eufranio N. Jr. , Namboothiri Irishi N. N. 
Published: January 2016

AbstractCascade reactions of amidines (II) with title compounds (I) and (IV) afford 2,4,5‐trisubstituted and 2,4‐disubstituted imidazoles (III), (V), and (VI), respectively.
ChemInform Abstract: Novel Synthesis and Cytotoxic Activity of 1,4‐Disubstituted 3‐Methylidene‐3,4‐dihydroquinolin‐2(1H)‐ones.
Authors: Pieta Marlena , Kedzia Jacek , Janecka Anna , Pomorska Dorota K. , Rozalski Marek , Krajewska Urszula , Janecki Tomasz 
Published: January 2016

AbstractThe title compounds are prepared in a 3‐step sequence starting from (I) via N‐alkylation, Grignard addition and Horner‐Wadsworth‐Emmons reaction with formaldehyde.
ChemInform Abstract: Base‐Promoted Synthesis of Dibenzoxazepinamines and Quinazolinimines under Metal‐Free Conditions.
Authors: Feng Jian‐Bo , Wu Xiao‐Feng 
Published: January 2016

AbstractDibenzoxazepinamines and quinazolinimines are synthesized in good to excellent yields from commercially available starting materials using a practical and efficient methodology.
ChemInform Abstract: Synthesis of Silaphenalenes by Ruthenium‐Catalyzed Annulation Between 1‐Naphthylsilanes and Internal Alkynes through C—H Bond Cleavage.
Authors: Tokoro Yuichiro , Sugita Kengo , Fukuzawa Shin‐ichi 
Published: January 2016

AbstractThe use of asymmetric alkynes affords mixtures of regioisomers.
ChemInform Abstract: Secondary Metabolites from Aspergillus fumigatus, an Endophytic Fungus from the Liverwort Heteroscyphus tener (Steph.) Schiffn.
Authors: Xie Fei , Li Xiao‐Bin , Zhou Jin‐Chuan , Xu Qing‐Qing , Wang Xiao‐Ning , Yuan Hui‐Qing , Lou Hong‐Xiang 
Published: January 2016

Abstractisolation, structure determination and cytotoxicity of three new metabolites, asperfumigatin (I), isochaetominine (II), and 8‐O‐methylasterric acid (III) along with nineteen known metabolites
ChemInform Abstract: New Rare Earth Langbeinite Phosphosilicates KBaREEZrP2SiO12 (REE: La, Nd, Sm, Eu, Gd, Dy) for Lanthanide Comprising Nuclear Waste Storage.
Authors: Kumar Sathasivam Pratheep , Gopal Buvaneswari 
Published: January 2016

AbstractKBaYMP2SiO12 (M: Zr, Sn), KBaLnZrP2SiO12 (Ln: La, Nd, Sm, Eu, Gd, Dy), and the spent nuclear fuel waste variant KBaY0.6La0.1Nd0.1Sm0.1 Eu0.1ZrP2SiO12 are prepared from stoichiometric aqueous solutions containing KCl, ZrOCl2, and SnCl4 to which Ba(NO3)2 and Y(NO3)3 solutions are added prior to precipitation with H3PO4 and Si(OEt)4 dissolved in a 1:1 mixture of HNO3 and EtOH.
ChemInform Abstract: The Diarylprolinol Silyl Ethers: Ten Years After
Authors: Donslund Bjarke S. , Johansen Tore Kiilerich , Poulsen Pernille H. , Halskov Kim Soeholm , Joergensen Karl Anker 
Published: January 2016

AbstractReview: [perspectives of different activation modes made available by the title aminocatalysis system; 85 refs.
A Potent and Selective P‐gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression
Authors: Guglielmo Stefano , Contino Marialessandra , Lazzarato Loretta , Perrone Maria Grazia , Blangetti Marco , Fruttero Roberta , Colabufo Nicola Antonio 
Published: January 2016

AbstractP‐glycoprotein (P‐gp) is a membrane protein responsible for the active transport of several endogenous and exogenous substances. It constitutes a defense mechanism and, at the same time, it severely compromises the success rate of antitumor chemotherapy. In this study a small library of alkyl/oxyalkyl derivatives of MC70 [4′‐(6,7‐dimethoxy‐3,4‐dihydro‐1H‐isoquinolin‐2‐ylmethyl)biphenyl‐4‐ol], a well‐known P‐gp inhibitor, was synthesized through straightforward functionalization of the phenolic group present in the structure of MC70. All compounds were characterized for their effect on P‐gp, proving capable of blocking P‐gp‐mediated calcein‐AM efflux with micromolar potency, following their ability to act as high‐affinity substrates of this transporter. Excitingly, compound 4 [6,7‐dimethoxy‐2‐((4′‐butoxybiphen‐4‐yl)methyl)‐1,2,3,4‐tetrahydroisoquinoline] exhibited low nanomolar potency (5.2 nm) and had a peculiar activity profile, acting both as a positive allosteric modulator and as a substrate of the transporter. A new and more efficient synthesis of MC70 is also described.
Small, abnormal B lymphoid blast populations in chronic myelogenous leukemia at diagnosis: Does this finding indicate an accelerated course?
Authors: Soma Lori , Oehler Vivian G. , Ding Cheng , Cherian Sindhu 
Published: January 2016

BackgroundThe 2008 WHO is not specific regarding subclassification of chronic myelogenous leukemia (CML) with less than 20% abnormal B lymphoid blasts (ABLB), and suggests patients with ABLB often show rapid progression (Swerdlow, 2008). Recent studies have shown variable outcomes when small abnormal B cell populations are seen by flow cytometry (El Rassi et al., Cancer 2015; 121:872–875; Vrotsos et al., Cytometry B Clin Cytom 2015).MethodsThe hematopathology database was searched (7.4‐year period), and patients identified through routine clinical study, who were BCR‐ABL1 positive CML and had an ABLB of less than 20%. Flow cytometric (FC) and histologic data was evaluated to determine immunophenotypic abnormalities, immunohistochemical patterns, and percentage of ABLB, hematogones, and mature B cells.ResultsSeven patients with CML and ABLB identified by FC studies were found, five of which also had available histologic material to review. ABLB by FC ranged from 0.006% to 3.4%, typically demonstrated an immunophenotype with increased CD10, increased CD19, and decreased CD38, without myeloid antigens, abnormalities similar to that reported previously (Vrotsos et al., Cytometry B Clin Cytom 2015). The ABLB population was found only in diagnostic samples and always with more numerous hematogones. By immunohistochemistry, three of five patients showed ≥10% TdT positive cells. All patients showed a response to tyrosine kinase inhibitor therapy, and no patients progressed to clinical lymphoid blast phase.ConclusionsImmature B cells, occasionally including a small subset with an abnormal phenotype can be observed in chronic phase CML at diagnosis. We believe an approach incorporating clinical data, cytogenetic/molecular findings, and morphologic evaluation may be helpful when determining the best management of CML patients at diagnosis if small ABLB populations are identified by FC. © 2016 Clinical Cytometry Society
Utility of TTF‐1 and Napsin‐A in the work‐up of malignant effusions
Authors: El Hag Mohamed , Schmidt Lindsay , Roh Michael , Michael Claire W. 
Published: January 2016

BackgroundSimilar to TTF‐1, Napsin‐A is recently used increasingly to differentiate between pulmonary adenocarcinoma (P‐ADC) and extra‐pulmonary adenocarcinoma (EP‐ADC). The aim of this study was to compare the performance of TTF‐1 and Napsin‐A in determining the primary origin of adenocarcinoma in malignant serous effusion.MethodsFollowing IRB approval, cellblocks from 139 cases of malignant serous effusions of histologically or clinically determined origin including: 26 P‐ADC, 108 EP‐ADC, 2 pulmonary squamous cell carcinoma (P‐SQC), and 3 pulmonary small cell carcinoma (P‐SCC) were retrieved. Each case was stained with Napsin‐A and TTF‐1 and evaluated for positivity and intensity of staining.ResultsNapsin‐A and TTF‐1 stained positive in 17/26 (65%) and 14/26 (54%) of P‐ADC and in 2/108 (1.8%) and 0/108 (0%) of EP‐ADC with a PPV of 89 and 100%, respectively. In combination, they positively stained 18/26 (70%) of P‐ADC with a PPV of 90%. Out of 9 poorly differentiated P‐ADC, 7 (78%) stained positive for Napsin‐A, while 4 (45%) were reactive for TTF‐1. Both Napsin‐A and TTF‐1 were negative in P‐SQC, while P‐SCC reacted positively for TTF‐1 in 2/3 (66%) of cases and none for Napsin‐A.ConclusionNapsin‐A and TTF‐1 are both useful markers in distinguishing P‐ADC from EP‐ADC. However, Napsin‐A performed better in poorly differentiated P‐ADC and its mimickers. The nuclear staining of TTF‐1 is crispier and much easier to interpret than Napsin‐A cytoplasmic stain. An antibody panel including TTF‐1 and Napsin‐A or a dual stain will be very helpful in determining the origin of metastatic adenocarcinoma in serous effusion. Diagn. Cytopathol. 2016;44:299–304. © 2016 Wiley Periodicals, Inc.