bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation of satellite and optical link dynamics in a quantum repeater constellation
Authors: Meister Jaspar , Kleinpaß Philipp , Orsucci Davide 
Published: October 2024

Abstract

Quantum repeaters and satellite-based optical links are complementary technological approaches to overcome the exponential photon loss in optical fibers and thus allow quantum communication on a global scale. We analyze architectures which combine these approaches and use satellites as quantum repeater nodes to distribute entanglement to distant optical ground stations. Here we simulate dynamic, three-dimensional ground station passes, going beyond previous studies that typically consider static satellite links. For this, we numerically solve the equations of motion of the dynamic system consisting of three satellites in low Earth orbit. The model of the optical link takes into account atmospheric attenuation, single-mode fiber coupling, beam wandering and broadening, as well as adaptive optics effects. We derive analytical expressions for the Bell state measurement and associated error rates for quantum memory assisted communications, including retrieval efficiency and state coherence. We consider downlink and uplink architectures for continental and intercontinental connections and evaluate the impact of satellite altitude and inter-satellite distance on the expected entanglement swapping rate. Our simulation model enables us to design different orbital configurations for the satellite constellation and analyze the annual performance of the quantum repeater under realistic conditions.
Deep Brain Stimulation for Refractory Epilepsy: A Meta-Analysis of Stimulation Parameters
Authors: Vahedi Pooya , Lotfinia Shahab , Zali Alireza , Ashrafi Farzad , Roozbeh Mahrooz , Tabatabavakili Yasmin , Roozbeh Mehrdad 
Published: October 2024

Abstract

Epilepsy affects 50 million people worldwide, with 30% not responding to antiepileptic drugs. Surgical resective intervention may help some patients, and neuromodulation therapies like deep brain stimulation are becoming important treatments for poorly controlled epilepsy. This study conducted a meta analysis following the PRISMA guidelines, searching PubMed, Scopus, and Web of Science databases for studies on deep brain stimulation in drug-resistant epilepsy patients. After screening 568 papers based on their titles and abstracts, we excluded systematic reviews, meta-analyses, animal studies, and other criteria. Two reviewers independently screened titles and abstracts for eligibility, and disagreements were resolved by a third reviewer. Full-text screening and data extraction were then performed for further assessment. Total of 52 studies were analyzed for a meta-analysis. These studies involved 748 patients and looked at various interventions, such as anterior nucleus thalamus, centromedian thalamic, and hypothalamus, with different stimulation parameters, including frequency and type. The results showed moderate variability and indicated that voltage, frequency, and stimulation type significantly influenced the success rates of the interventions.
Exploring Saffron's Therapeutic Potential: Insights on Phytochemistry, Bioactivity, and Clinical Implications
Authors: Sen Debasis , Rathee Sunny , Pandey Vishal , Jain Sanjay K. 
Published: October 2024

Abstract:
Saffron, derived from the Crocus sativus plant, has been revered for centuries for its culinary,
medicinal, and cultural significance. This review provides a comprehensive overview of saffron's chemical
constituents and phytochemistry, elucidating its rich profile of bioactive compounds. Emphasis is placed on exploring
the bio-accessibility, bioavailability, and bioactivity of saffron's phytochemicals, laying the foundation
for understanding its pharmaceutical significance. The pharmaceutical importance of saffron and its phytochemicals
is thoroughly examined, focusing on their diverse therapeutic properties. These include anticancer,
antidiabetic, antioxidant, antimicrobial, anti-inflammatory, antinociceptive, anticonvulsant, antidepressant,
learning and memory enhancement, cardiovascular, and antihypertensive properties. Such multifaceted pharmacological
activities underscore saffron's potential as a valuable medicinal resource. Clinical studies investigating
the efficacy and safety of saffron in various health conditions are synthesized, providing insights into
its clinical applications. Moreover, toxicity assessments in animal models, encompassing acute, subacute,
subchronic, and developmental toxicity, are discussed to delineate the safety profile of saffron and its bioactive
constituents. Finally, recent advances and future perspectives in saffron research are highlighted, underscoring
emerging trends and potential avenues for further exploration. This review serves as a comprehensive
resource for researchers, clinicians, and stakeholders interested in harnessing the therapeutic potential of saffron
while ensuring its safe and effective utilization in healthcare settings.
Anti-Inflammatory Potential of Costus speciosus rhizome Bioactive Phytochemicals: A Combined GC-MS and Computational Approach Targeting
TLR-4 Signaling
Authors: Raj Aditya , Chakravorty Arghya , Luktuke Sahil , Santra Sourav , Das Sudip , Sahoo Subhrajeet , Ramesh Karthikeyan , A Nidha Fathima , Sana Siva Sankar , Jayanthi Sivaraman , Samanta Arabinda , Raghavan Vimala 
Published: October 2024

Background:
Plants represent a rich reservoir of bioactive compounds with established
therapeutic value in diverse diseases. Notably, the Toll-like receptor-4 (TLR-4) signaling pathway
plays a pivotal role in inflammation. Upon engagement with pro-inflammatory ligands like
lipopolysaccharide, TLR-4 triggers downstream cascades involving nuclear factor ĸappa B and mitogen-
activated protein kinases. This signaling cascade ultimately dictates the onset and progression
of inflammatory diseases. Therefore, targeting TLR-4 signaling offers a promising therapeutic
approach for managing inflammatory disorders.

Methods:
This study investigated the potential of Costus speciosus rhizome phytocompounds, a
traditional medicinal plant, as novel as modulators of TLR-4 signaling, highlighting their mechanisms
of action and potential clinical applications. In the present study, 18 phytocompounds isolated
from the rhizome of Costus speciosus, were studied against TLR-4/AP-1 signaling, which is
implicated in the inflammatory process using a computational approach.

Results:
The compounds exhibited binding affinities ranging from -4.087 to -8.93 kcal/mol with
the TLR-4 protein due to the formation of multiple intermolecular interactions. Benzenepropanoic
acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, methyl ester (compound 7) exhibited exceptional
binding energy (-8.93 kcal/mol), indicating strong affinity for the TLR-4 protein. Additionally,
compound 7 displayed favorable ADMET properties, suggesting promising drug development potential.
Molecular dynamics simulations confirmed the stability of the compound 7-TLR4 complex,
further supporting its ability to modulate TLR-4 signaling.

Conclusion:
These findings highlight the therapeutic potential of Costus speciosus phytocompounds,
particularly compound 7, as potent anti-inflammatory modulators. Further research is warranted
to validate their anti-inflammatory and neuroprotective effects in pre-clinical models, paving
the way for their development as novel therapeutic agents for inflammatory diseases.
An Insight into Medicinal Chemistry and SAR Studies of Cholinesterase and BACE-1 Inhibitors for Alzheimer's Disease
Authors: Shome Abhimannu , Jha Keshav Taruneshwar , . Chahat , Chawla Viney , Chawla Pooja A. 
Published: October 2024

Abstract:
Alzheimer's Disease (AD) is a serious neurodegenerative condition that predominantly
impacts the cholinergic neurons of the entorhinal cortex and hippocampal regions, playing a critical
role in learning, navigation, and brain processing. This paper aims to discuss the three main hypotheses
of Alzheimer's disease, focusing on neurotoxicity and neurodegeneration caused by mitochondrial
dysfunction and ROS production, particularly analyzing the susceptibility differences between
genders. Our comprehensive review focuses on significant findings from the past five years, particularly
on Cholinesterase (ChE) and BACE-1 inhibitors. Researchers have conducted a detailed analysis
of in vitro, in silico, and in vivo data, incorporating extensive Structure-Activity Relationship
(SAR) studies. The reviewed papers have been sourced from platforms, such as Google Scholar,
Semantic Scholar, and ClinicalTrials.gov, and have been selected based on their AChE and BACE-1
inhibitory activity and structural motif similarity. The review identifies the most effective compounds
targeting ChE and BACE-1, highlighting acridine, dihydropyridine, and thiazole-coumarin
hybrids for ChE inhibition, and oxadiazole, benzofuran, and dihydropyrimidinone for BACE-1 inhibition.
This demonstrates a diverse array of potent heterocyclic hybrids. The review presents a varied
compilation of scaffolds showing promise in treating Alzheimer's disease, highlighting the potential
of specific compounds against ChE and BACE-1. Given the critical insights derived from our
analysis, we posit that this compilation will substantially contribute to the ongoing efforts to combat
neurodegeneration and prolong dementia, underscoring the importance of continuous research in
this domain.
Biofuels Policy as the Indian Strategy to Achieve the 2030 Sustainable Development Goal 7: Targets, Progress, and Barriers
Authors: Mutabaruka Michel , Kaur Manmeet , Singla Sanjay , Sharma Purushottam , Kaur Gurpreet , Singh Gagandeep 
Published: October 2024

Introduction:
The use of 20% blended biofuels to fossil fuels is one of the important
targets of the Government of India to address the impacts of Climate Change, energyrelated
environmental pollution, and illnesses due to air pollution.

Method:
The National Policy on Biofuels 2018 (NPB 2018) is in place to boost the emerging
production of biofuels and, therefore, respond to different international agreements, including
the Sustainable Development Goals (SDGs) and the Paris Agreement. Hence, this article examined
the production of biofuels in India in line with Agenda 2030 to project the share to be taken
by biofuels as its contribution to the country’s energy needs.

Result:
The results were compromising; it was observed that the data from 2000 up to 2017
were not on the side of realizing the targets of production and consumption of biofuels in India,
whereas the data from 2018 up to now showed a hope of achieving 2030 set goal of E20 petrol
in 2025-26, and E5 diesel in 2030. It was clear that the production of bioethanol was boosting
compared to its sibling biodiesel, and renewable energy will continue to have a hard take a
good share in the total annual energy used in India.

Conclusion:
It is recommended to share data between different stakeholders to promote more
research, as the low performance in achieving the targets was due to poor communication and
missing technology, rather than the lack of feedstock or unavailability of production facilities.
Mobile Phone Syndromic Surveillance for Respiratory Conditions in an Emergency (COVID-19) Context in Colombia: Representative Survey Design
Authors: Vecino-Ortiz Andres I , Guzman-Tordecilla Deivis Nicolas , Maniar Vidhi , Agudelo-Londoño Sandra , Franco-Suarez Oscar , Aya Pastrana Nathaly , Rodríguez-Patarroyo Mariana , Mejía-Rocha Marino , Cardona Jaime , Chavez Chamorro Mariangela , Gibson Dustin 
Published: October 2024

Background
Syndromic surveillance for respiratory infections such as COVID-19 is a crucial part of the public health surveillance toolkit as it allows decision makers to detect and prepare for new waves of the disease in advance. However, it is labor-intensive, costly, and increases exposure to survey personnel. This study assesses the feasibility of conducting a mobile phone–based respiratory syndromic surveillance program in a middle-income country during a public health emergency, providing data to support the inclusion of this method in the standard infection control protocols at the population level.

Objective
This study aims to assess the feasibility of a national active syndromic surveillance system for COVID-19 disease in Colombia.

Methods
In total, 2 pilots of syndromic mobile phone surveys (MPSs) were deployed using interactive voice response technology in Colombia (367 complete surveys in March 2022 and 451 complete surveys in April and May 2022). Respondents aged 18 years and older were sampled using random digit dialing, and after obtaining consent, they were sent a 10-minute survey with modules on sociodemographic status, respiratory symptoms, past exposure to COVID-19 infection and vaccination status, preferences about COVID-19 vaccination, and information source for COVID-19. Pilot 1 used a nationally representative sample while pilot 2 used quota sampling to yield representative results at the regional level. In this work, we assessed the performance characteristics of the survey pilots and compared the demographic information collected with a nationally representative household survey.

Results
For both pilots, contact rates were between 1% and 2%, while participation rates were above 80%. The results revealed that younger, female, and higher educated participants were more likely to participate in the syndromic survey. Survey rates as well as demographics, COVID-19 vaccination status, and prevalence of respiratory symptoms are reported for both pilots. We found that respondents of the MPSs are more likely to be younger and female.

Conclusions
In a COVID-19 pandemic setting, using an interactive voice response MPS to conduct syndromic surveillance may be a transformational, low-risk, and feasible method to detect outbreaks. This evaluation expects to provide a path forward to the inclusion of MPSs as a traditional surveillance method.
Production et circulation de récits amérindiens, ghostwriting et langue fantôme
Authors: Jobim José Luís 
Published: October 2024

Neste artigo, vamos analisar duas narrativas, atribuídas a Rigoberta Menchú e Davi Kopenawa, que possuem algumas características comuns, por serem dirigidas a um público “branco” (embora estes autores sejam ameríndios) e por descreverem elementos da cultura ameríndia, apresentando fatos históricos referentes ao encontro da cultura ameríndia com a cultura abrangente, em seus respectivos países (Guatemala e Brasil), partindo de uma perspectiva indígena, e sendo originalmente publicadas em línguas diferentes daquelas de seus autores ameríndios, além de serem organizadas e estruturadas por pessoas ligadas à cultura francesa, a partir de perspectivas disciplinares “ocidentais”. Todas estas características das narrativas analisadas geram muitas questões que dizem respeito aos papeis dos autores.
Ценностные ориентиры современной молодежи и формирование функциональной грамотности студента: из опыта преподавания дисциплины «Основы российской государственности»
Authors: Сазонова Наталия Ивановна , Рудницкий Юрий Александрович 
Published: October 2024

Рассматривается опыт формирования функциональной грамотности студентов в рамках учебной дисциплины «Основы российской государственности». Материалом для анализа является опыт преподавания дисциплины «Основы российской государственности» в двух высших учебных заведениях, полученный в сентябре – декабре 2023 г. Показано, что опора на ценностные установки молодежи, в частности любовь к малой родине (региону), ценности творческой и профессиональной самореализации позволила стимулировать развитие читательской, коммуникативной и информационной грамотности: умение работать с текстами различной тематики, критически отбирать информацию, корректно представлять ее аудитории. Сделан вывод о том, что опора на базовые ценностные установки молодежи является достаточно результативным подходом в плане стимулирования интереса к изучению дисциплины и залогом формирования элементов функциональной грамотности студентов. Методические приемы такого формирования в рамках гуманитарных дисциплин в высшем учебном заведении могут быть предметом дальнейших дискуссий.
The article is about the experience of forming functional literacy of students during the course ‘Fundamentals of Russian statehood’. The relevance of the problem is associated with dynamic changes in the economy, social and cultural life, which requires from the future specialist a broad outlook, knowledge and skills to adapt in the changing world. The material for analysis is the experience of teaching the course ‘Fundamentals of Russian statehood’ in two higher educational institutions in September - December 2023. It shows the reliance on the value attitudes of young people, in particular, the love for ‘small motherland (region), the values of creative and professional self-realisation, allowed to stimulate the development of reading, communicative and information literacy: the ability to work with texts on different topics, to critically select information, to present it correctly to the audience. The article concludes that the reliance on the basic value attitudes of young people is a quite effective approach to stimulate interest in the learning process, which is the key to the formation of elements of functional literacy of students. These methodological techniques of humanities disciplines in higher education can be the subject of further discussions.
Отражение традиционного русского костюма в современном дизайн-образовании
Authors: Замазий Ольга Сергеевна , Кислых Любовь Васильевна , Мальцева Виктория Алексеевна 
Published: October 2024

На основе трудов отечественных ученых (искусствоведов, педагогов, IT-специалистов) рассмотрены основные задачи современного дизайн-образования, направленного на подготовку компетентного, креативного выпускника, способного применять этнокультурный материал в профессиональной сфере, в том числе средствами цифровых технологий. В основе исследования – механизмы внедрения в содержательный компонент подготовки будущих дизайнеров материала традиционного русского костюма. Важным подтверждением значимости включения материала традиционного русского костюма в дизайн-образование является качество и новизна проектных разработок и результативность участия проектов студентов в конкурсно-выставочной деятельности. В ходе исследования была доказана высокая эффективность использования материала традиционного русского костюма в современном дизайн-образовании в формировании профессиональных компетенций, направленных на совершенствование будущего специалиста, и универсальных, способствующих воспитанию личности в традиции своей культуры. Показателем высокого уровня освоения студентами материала традиционного русского костюма стал рост числа выполненных проектов коллекций одежды в этностиле, что является успешным использованием материала традиционного русского костюма в современном дизайн-образовании.
On the basis of works of domestic scientists (art historians, teachers, IT-specialists) the main tasks of modern design education, aimed at training a competent, creative graduate able to apply ethnocultural material in the professional sphere, including by means of digital technologies, are considered. The study is based on the mechanisms of introducing the material of traditional Russian costume into the content component of training future designers. An important confirmation of the significance of including the material of traditional Russian costume in design education is the quality and novelty of project developments and the effectiveness of students’ projects participation in competition and exhibition activities. In the course of the study was proved the high efficiency of using the material of traditional Russian costume in modern design education in the formation of professional competencies aimed at improving the future specialist, and universal, contributing to the education of the individual in the traditions of their culture. The high level of students’ mastering the material of traditional Russian costume was indicated by the growth of the number of completed projects of ethno-style clothing collections, which is a successful use of the material of traditional Russian costume in modern design education.
Мотивы выбора китайскими студентами и аспирантами страны обучения
Authors: Ревякина Валентина Ивановна , Лю Цянь , Ма Хайсинь 
Published: October 2024

Интернационализация высшего образования ведет к тому, что количество иностранцев, обучающихся в России, постоянно увеличивается, что значительно расширяет рамки высшего образования. Поскольку Россия является заинтересованной страной для сотрудничества с общенациональной китайской инициативой «Один пояс, один путь», то акцентируется внимание не только на политической, экономической областях и в сфере обмена перспективными студентами, но и для использования социальных и образовательных возможностей России для обучения студентов и аспирантов из КНР. Вопреки глобальной пандемии, количество китайских студентов и аспирантов, обучающихся в России, сегодня значительно увеличивается, что говорит о ряде факторов, делающих обучение в РФ значимым и перспективным для китайских учащихся. Рассмотрены основные мотивы выбора России китайскими студентами как приоритетного места для высшего образования.
Currently, in world practice, in connection with the creation of a unified educational space, one of the urgent issues is the internationalization of education and training of specialists that meet the requirements of time. The number of foreigners studying in Russia is constantly increasing, which significantly expands the scope of higher education. Russia is the country interested in cooperation with Chinese national initiative «One belt, One Road». This program focuses on the political, economic and exchange fields of promising students to build human potential. In the 2000s, China`s policy took a firm course towards the humanitarian paradigm. The values of education began to be considered as a resource of development of the country and nation. Only an educated person can become successful and useful for his country. Despite the global pandemic, the number of Chinese students and graduate students studying in Russia is increasing significantly today. As a strategic partners in cooperation Russia and China are constantly increasing Sino-Russian exchanges of students and postgraduates as a joint training of specialists in the field of education. Co-education allows young people to absorb the cultural essence and language of the two countries, expands the horizons of students and contributes to their general cultural and professional development. It emphasizes the need for knowledge of foreign languages for a modern person as a guarantee of his competitiveness in employment. The attractiveness of Russia for training Chinese youth indicates the strengthening of educational cooperation between the two countries. The model of co-education and student exchange corresponds to the complex multi-level training of specialists as a model of multi-channel cultural and educational Chinese-Russian cooperation.