bluuebunny/crossref_metadata_2025_split huggingface dataset:
γδ T-cell lymphoma: a rare entity mimicking hemophagocytic syndrome-report of two cases
Authors: Maheshwari Ujwala , Mahore Kalyani , Pereira Evith , Dhar Reeta 
Published: July 2017

γδ T-cell lymphoma is a rare extranodal and systemic neoplasm which accounts for less than 1% of all NHL having peak incidence in adolescents and young adults with a male predominance. Study report two cases, 29 and 25 years male presented with fever, abdominal pain and pancytopenia; one had hepatosplenomegaly while other had marked splenomegaly respectively and both showing feature of hemophagocytosis. Both underwent splenectomy. On gross examination, the spleen was markedly enlarged and shows a deep brown cut-surface. Histologically the normal structure of the spleen is totally effaced by a monotonous lymphoid population consisting of medium-large sized lymphoid cells with vesicular chromatin and small eosinophilic nucleolus with tumor cells showing moderate amount of eosinophilic cytoplasm. Liver biopsy showed regenerative changes in parenchyma and sinusoidal involvement by tumour cells. Peripheral smear revealed atypical lymphocytes with pancytopenia. Bone marrow aspiration showed moderate neoplastic infiltrate by lymphoid cells. Immunophenotypic study showed tumour cells expressing CD3, CD56, CD 2 (dim), TIA-1, TCR-gamma. The tumour cells were immunonegative for CD20, CD5, CD4, CD8, granzyme B, CD7, CD10 and CD 23. Immunophenotypic study is must for diagnosis of γδ T-cell lymphoma which can mimic hemophagocytic syndrome.
HYPOCENTER DETERMINATION AND CLUSTERING OF VOLCANO-TECTONIC EARTHQUAKES IN GEDE VOLCANO 2015
Authors: Nugraha Aulia Kharisma , Maryanto Sukir , Triastuty Hetty 
Published: July 2017

<p class="abstrak"><span lang="EN-US">Gede volcano is an active volcano in West Java, Indonesia. Research about determination the volcano-tectonic earthquake source positions has given results using volcano-tectonic earthquakes data from January until November 2015. Volcano-tectonic earthquakes contained deep (VT-A) have frequency (maximum amplitude) range 5 – 15 Hz. Furthermore, they contain shallow earthquake, VT-B have range 3-5 Hz and LF have range 1-3 Hz. Geiger’s Adaptive Damping (GAD) methods used for determining the hypocenter of these volcano-tectonic (VT) events. Hypocenter distribution divided into 4 clusters. Cluster I located in the crater of Gede volcano dominated by VT-B earthquakes their depth range 2 km below MSL to 2 km above MSL including the VT-B swarm. The seismic sources in cluster I indicated dominant due to the volcanic fluid or gas filled in conduit pipes. Cluster II located at the west of Gede volcano caused by Gede-Pangrango fault-line dominated by VT-A earthquakes with depths range 1.5 km below MSL to 700 m above MSL. Cluster III located in the North of Gede volcano dominated by VT-A events there caused by graben fault area with those depths range 7.5 – 1.65 km below MSL. Cluster IV located in South West of Gede volcano contained VT-A earthquakes with depth range at 10 km below MSL and VT-B earthquakes this depth 2 km below MSL. Due to magma intrusion filled into fractures of the fault in the West of Gede volcano this shallow magma filling-fractures and degassing in subsurface assumed dominates the volcano-tectonic events from January to November 2015 due to faults extends from North to South occured in the West of Gede volcano.</span></p>
Use of Corporal Punishment in Relation to Institutional and Personal Variables of Teachers
Authors: Garg Mamta Rani 
Published: July 2017

Corporal punishment is ingrained in schools worldwide as a normal disciplinary measure despite the legal ban on it in around 125 countries and India is one of these. Studies and media reports have shown a high prevalence rate (around 40% to 99.9%) across different parts of India. The unequal rate of punishment may be associated with school contexts. Therefore, it was intended to identify those institutional variables and teachers characteristics which determine the difference in the rate of use of corporal punishment. For this, data was collected from 202 teachers from 84 schools of Punjab. Results indicate that institutional variable such as school type, its location, organizational climate and personal variables of teachers, namely, their gender, marital status teaching experience, job satisfaction of teachers cause a difference in frequency of use of corporal punishment by teachers in schools. In this paper, the probable factors associated with these variables have also been explored.
CO-CULTIVO DE ASPERGILLUS NIGER E CERIPORIOPSIS SUBVERMISPORA PARA PRODUÇÃO DE ENZIMAS LIGNOCELULOLÍTICAS E AÇÚCARES REDUTORES
Authors: Magri Priscilla Maria , Dias Sandra de Cássia 
Published: July 2017

Etanol de segunda-geração pode ser produzido a partir de resíduos agrícolas tais como bagaço de cana-de-açúcar e palha de milho. Para disponibilizar os açúcares fermentáveis da biomassa lignocelulósica para a fermentação alcoólica é necessário o pré-tratamento seguido da hidrólise enzimática da celulose. Os custos envolvidos com a hidrólise enzimática são elevados e muitas vezes inviabilizam a aplicação em escala industrial. Esse trabalho avaliou o co-cultivo de Aspergillus niger e Ceriporiopsis subvermispora (em fermentação em estado sólido (FES) utilizando bagaço de cana-de-açúcar e palha de milho) para a produção de enzimas lignocelulolíticas e açúcares redutores. O planejamento fatorial 22 foi usado e as variáveis analisadas foram o pré-tratamento alcalino e o pré-tratamento microbiológico (co-cultivo), nos níveis máximos (+) e mínimos (-). A metodologia aplicada consistiu na fermentação em estado sólido seguida de determinações das atividades enzimáticas e dos açúcares redutores. Para o bagaço de cana-de-açúcar o co-cultivo não foi favorável para a produção das enzimas FPase (celulases totais) e açúcares redutores, porém foi a condição que mais favoreceu a produção de CMCase (endoglicanases). A melhor condição para a produção de FPase e açúcares redutores foi o mono-cultivo de Aspergillus niger em bagaço de cana-de-açúcar pré-tratado. Para a palha de milho, a associação do pré-tratamento alcalino com o co-cultivo dos micro-organismos favoreceu a produção de FPase e açúcares redutores. Já a produção de CMCase foi maior nos ensaios nos quais a matéria-prima não foi tratada e ocorreu o co-cultivo. Portanto, para a produção de CMCase, o co-cultivo foi a melhor condição para os dois resíduos agrícolas e dispensa o uso do tratamento químico, diminuindo assim os custos com o processo.
Perguruan Tinggi Agama Islam Swasta Antara Tuntutan dan Realita
Authors: Yasin Muhammad 
Published: July 2017

<p>Abstract</p><p>Lembaga pendidikan tinggi swasta merupakan lembaga tinggi yang setara dengan lembaga tinggi yang diselenggarakan pemerintah. Kiprah lembaga pendidikan swasta sama sebagaimana negeri, mereka ikut andil besar dalam mencerdaskan anak bangsa. Hal senada tentunya segala apa yang diharapkan dan diprioritasnya sama, namun kenyataan yang ada di alapngan, lembaga pendidikan tinggi yang dikelola oleh yayasan atau organisasi masyarakat selalu kurang mendapat perhatian, apa yang diharapkan terkadang pula masih jauh dari harapan. Lembaga Penjaminan Mutu, akhir-akhir ini muncul sebenarnya untuk menjembatani lajunya perjalanan lembaga tersebut untuk melayani, mengontrol dan mengevaluasi keberadaan lembaga tersebut. Kebutuhan lembaga ini tentunya harus mendapat dukungan oleh civitas akademika. Visi misi lembaga pendidikan yang dicanangkaan dan diharapkan oleh yayasan atau ormas yang menangani lembaga pendidikan, harus dapat dilihat bilamana Lembaga Penjaminan Mutu berjalan dengan baik. Begitu juga control yang dilakukan oleh pemerintah melalui Badan Akreditas Nasional Perguruan Tingngi (BAN PT) menjadi kebutuhan lembaga / instansi, karena melalui assesmen keberadaan lembaga tersebut layak mendapatkan pengakuan secara nasional, dengan harapan masyarakat pengguna tidak mengalami kekecewaan saat menempuh proses pendidikan.</p><p> <em>Kata Kunci : PTAIS , Lembaga Penjaminan Mutu, dan BAN PT.</em></p>
Wastewater pond systems using chemical precipitation (fellings dams): state of the art in Sweden
Authors: Hanaeus J. , Hanaeus Å. 
Published: July 2017

Abstract
Chemical precipitation in wastewater stabilization ponds – in Scandinavia called fellings dams – has been in operation for more than 50 years. Slaked lime and aluminium salts are the most common chemicals used for precipitation. Long and narrow forms of the ponds and a detention time of at least 5 days have shown, even at a low water temperature and below an ice cover, to produce an average effluent quality of 70 mg CODCr/l, 0.2 mg Tot-P/l, 20 mg Tot-N/l (CODCr: chemical oxygen demand; Tot-P: total phosphorus; Tot-N: total nitrogen) and low levels of pathogenic bacteria. The systems use low amounts of energy and no wastewater is by-passed at the plants. Fellings dams have recently been tried to support overloaded wastewater collection systems.
Frontotemporal Lobar Degeneration (FTLD): Review and Update for Clinical Neurologists
Authors: Hernandez Isabel , Fernandez Maria-Victoria , Tarraga Lluis , Boada Merce , Ruiz Agustín 
Published: July 2017

Background:
Frontotemporal Dementia (FTD) is a heterogeneous group of disorders and the
second most frequent cause of early onset dementia making it the highest number of inherited cases.

Review Summary: FTD is characterized by considerable variability in clinical, genetic and histopathologic
features. Patients may present symptoms ranging from behavioural disturbances to different
language disorders, with or without motor neuron disorders or associated parkinsonism. Atrophy in frontal
and temporal lobes is the most relevant radiological finding. In the last 10 years, the knowledge of
this clinical entity has undergone remarkable changes both genetically and histopathologically, which
have served to establish more consistent clinical criteria. Until now, 10 genes causative of FTLD have
been described and up to four different proteins causative of atrophy have been detected in aggregates.

Conclusion:
This review is mostly addressed to clinicians and aims to provide basic knowledge of these
neurodegenerative disorders and clarify the complex FTD scenario.
Effect of Number of Bifunctional Chelating Agents on the Pharmacokinetics and Immunoreactivity of 177Lu-labeled Rituximab: A Systemic Study
Authors: Guleria Mohini , Das Tapas , Kumar Chandan , Sharma Rohit , Amirdhanayagam Jeyachitra , Sarma Haladhar D. , Dash Ashutosh 
Published: July 2017

Objective: Monoclonal antibodies (mAbs) have been radiolabeled with a variety of radioisotopes
utilizing various kinds of bi-functional chelating agents (BFCAs) with an aim to develop suitable agents for
radioimmunotherapy. The number of BFCA moieties present per antibody molecule plays a significant role in
determining the pharmacokinetics and immunoreactivity exhibited by the radiolabeled antibodies. The objective
of the present study is to evaluate the effect of the number of BFCA moieties present per antibody molecule on
the pharmacokinetics and immunoreactivity of the 177Lu-labeled Rituximab.

Methods:
Three different mAb-BFCA conjugates were prepared using different molar ratios of Rituximab
(mAb) to p-NCS-benzyl-DOTA (BFCA) viz. 1:5, 1:10 and 1:50 employing different reaction conditions.
Studies were carried out to determine the average number of BFCAs attached per mAb molecule. All the three
mAb-BFCA conjugates were labeled with 177Lu(III) and were subsequently evaluated in normal Swiss mice to
ascertain their respective pharmacokinetic behavior. In-vitro studies were also performed in Raji cell lines (human
burkitt's lymphoma) for determining the effect of increasing number of BFCAs attached per mAb molecule
on the immunoreactivity of the resultant 177Lu-labeled mAb-BFCA complexes.

Results:
177Lu-labeled mAb-BFCA complex prepared corresponding to 1:50 mAb to BFCA ratio exhibited the
least non-specific uptake and rapid clearance from majority of the organs, but also exhibited least immunoreactive
fraction (IRF = 19.37%). On the other hand, 177Lu-labeled mAb-BFCA complex prepared corresponding
to 1:5 mAb to BFCA ratio exhibited the highest non-specific uptake and slower clearance pattern, but
highest IRF (71.17%). 177Lu-labeled mAb-BFCA complex prepared corresponding to 1:10 mAb:BFCA ratio
exhibited intermediate pharmacokinetic behaviour with moderate IRF (53.05%).

Conclusions:
The present study indicates that antibody to BFCA ratio plays a crucial role in determining the
immunoreactivity and pharmacokinetic behavior of the radiolabeled antibodies and must be prudently chosen
for their successful therapeutic application.
The Spectrum of Familial Hypercholesterolemia (FH) in Saudi Arabia: Prime Time for Patient FH Registry
Authors: Alallaf Faisal , H.Nazar Fatima Amanullah , Alnefaie Majed , Almaymuni Adel , Rashidi Omran Mohammed , Alhabib Khalid , Alnouri Fahad , Alama Mohamed-Nabil , Athar Mohammad , Awan Zuhier 
Published: July 2017

Background:Familial hypercholesterolemia (FH) is a life-threatening inherited condition. Untreated patients have the risk to develop raised plasma levels of cholesterol, atherosclerosis and cardiovascular disease (CVD). If diagnosed and treated early in life, the pathological consequences due to atherosclerosis could be avoided and patients with FH can have an anticipated normal life. Mounting evidence suggests that FH is underdiagnosed and undertreated in all populations. The underlying molecular basis of FH is the presence of mutations in one or more genes in the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB) or proprotein convertase subtilisin/kexin 9 (PCSK9). However, their prevalence is largely unknown in Saudi Arabia but given the high rates of consanguinity, the prevalence appears to be higher. Furthermore, the high prevalence of obesity and diabetes mellitus in Saudi Arabia increases the vascular disease burden in FH cases by adding additional CVD risk factors.Objective:This article explores the spectrum of FH-causing mutations in the highly consanguineous Saudi community, the need for establishing the Saudi FH registry, the challenges in creating gene databases, and cascade screening.Conclusion:The establishment of FH registry and genetic testing should raise awareness not only among healthcare professionals, but the general population as well. It also helps to provide the best treatment regimen in a cost effective manner to this under-recognised population of FH patients.
The Added Value of Postoperative Axial Imaging in Developmental Dysplasia of the Hip
Authors: Alassaf Nabil , Abuhaimed Joud , Almahmoud Nouf , Binkhulaif Rawan 
Published: July 2017

Background:Redislocation is a dreaded complication after reduction of developmental dysplasia of the hip (DDH) in young children. While early detection facilitates urgent reoperation, delayed revisions are more complicated. Despite the weak evidence, an axial postoperative imaging tool is recommended. This study’s goal is to compare the effectiveness of conventional pelvic radiography alone and axial imaging.Methods:Data were collected retrospectively between 2012 and 2016. One study group comprised consecutive patients who had operative reduction followed by routine low-dose computed tomography (CT). Hips that had anteroposterior pelvic radiographs as the only confirmatory tool were used as a reference group.Results:We identified 241 patients (339 hips). The mean age and follow up were 19.6 months ± 9.3, and 15.5 months ± 11.1, respectively. There were 147 hips in the radiography group and 192 in the CT group. Radiography detected only three out of nine redislocations during the same admission; in contrast, 2/2 redislocations in the routine CT group were addressed before hospital discharge (p<0.01). There was no significant delay in hospital discharge when CT was used (p= 0.28).Conclusion:Conventional radiography is not as effective as axial imaging in preventing late detection of redislocation.Level of Evidence:level III, Diagnostic Study.
Effect of COD/N Ratio on Removal Performances in Two Subsurface Wastewater Infiltration Systems
Authors: Fei Hexin , Pan Jing , Tong Deli , Huang Linli , Yu Long , Sun Yafei , Qi Shiyue , Huang Yaoyao 
Published: July 2017

ABSTRACT: Dissolved oxygen (DO), were investigated. Aerobic conditions were effectively developed in 50 cm depth of the matrix and anoxic or anaerobic conditions were not changed in 80 and 110 cm depth by intermittent aeration, which encouraged nitrification. Increased influent COD/N ratio led to lower COD and nitrogen removal in conventional SWISs. Sufficient carbon source in high COD/N ratio influent promoted denitrification with intermittent aeration. High removal rates of COD (95.68 ± 0.21%), TP (92.02 ± 0.28%), ‐N (99.33 ± 0.05%), and ‐ (89.65 ± 0.6%) were obtained with influent COD/N ratio of 12 in aerated SWISs. Under the COD/N ratio of 12 and 18, intermittent aeration boosted the growth and reproduction of nitrifying bacteria and denitrifying bacteria. Meanwhile, nitrate and nitrite reductase activities with intermittent aeration were higher than that without aeration in 80 and 110 cm depths.
Sludge Reduction in the Activated Sludge Process Strengthened by Enhanced Ozonation Oxidation
Authors: Chen Yingwen , Zhang Wei , Feng Yangyang , Huang Qiong , Shen Shubao 
Published: July 2017

ABSTRACT: A novel radial‐axial mixer and microbubble ozone reactor for enhancing sludge disintegration was designed. In the batch studies, the new reactor was shown to be significantly effective in improving sludge disintegration and increasing ozone utilization. For ozone dosages of 0.02 to 0.3 gO3/gTSS (total suspended solids) at pH = 10, the average sludge disintegration ratio was more than 17 ± 0.83% higher than that of the conventional reactor. An activated sludge process coupled with discharged sludge ozonated was run for 60 days to evaluate the influence of ozonated sludge feeding on the sludge yield coefficient and effluent quality. Although the effluent chemical oxygen demand (COD) and suspended solids (SS) increased slightly, these values were well below the discharge limit. Furthermore, a sludge reduction efficiency of 95% was attained. The experimental results indicated that the combination of sludge ozonation with the activated sludge process could generate a high quality of effluent and a small sludge yield.
Marrying Step Feed with Secondary Clarifier Improvements to Significantly Increase Peak Wet Weather Treatment Capacity: An Integrated Methodology
Authors: Daigger Glen T. , Siczka John S. , Smith Thomas F. , Frank David A. , McCorquodale J. A. 
Published: July 2017

ABSTRACT: The need to increase the peak wet weather secondary treatment capacity of the City of Akron, Ohio, Water Reclamation Facility (WRF) provided the opportunity to test an integrated methodology for maximizing the peak wet weather secondary treatment capacity of activated sludge systems. An initial investigation, consisting of process modeling of the secondary treatment system and computational fluid dynamics (CFD) analysis of the existing relatively shallow secondary clarifiers (3.3 and 3.7 m sidewater depth in 30.5 m diameter units), indicated that a significant increase in capacity from 416 000 to 684 000 m3/d or more was possible by adding step feed capabilities to the existing bioreactors and upgrading the existing secondary clarifiers. One of the six treatment units at the WRF was modified, and an extensive 2‐year testing program was conducted to determine the total peak wet weather secondary treatment capacity achievable. The results demonstrated that a peak wet weather secondary treatment capacity approaching 974 000 m3/d is possible as long as secondary clarifier solids and hydraulic loadings could be separately controlled using the step feed capability provided. Excellent sludge settling characteristics are routinely experienced at the City of Akron WRF, raising concerns that the identified peak wet weather secondary treatment capacity could not be maintained should sludge settling characteristics deteriorate for some reason. Computational fluid dynamics analysis indicated that the impact of the deterioration of sludge settling characteristics could be mitigated and the identified peak wet weather secondary treatment capacity maintained by further use of the step feed capability provided to further reduce secondary clarifier solids loading rates at the identified high surface overflow rates. The results also demonstrated that effluent limits not only for total suspended solids (TSS) and five‐day carbonaceous biochemical oxygen demand (cBOD5) could be maintained, but also for ammonia‐nitrogen and total phosphorous (TP). Although hydraulic limitations in other parts of the WRP prevent this full capacity to be realized, the City is proceeding to implement the modifications identified using this integrated methodology.
Effects of Flow Fluctuation on Dilution and Spreading in a Self‐Affine Fracture
Authors: Dou Zhi , Zhou Zhifang , Guo Qiaona , Lu Xiaohui 
Published: July 2017

ABSTRACT: In this work, the spreading and dilution (mixing) processes of the miscible compound were analyzed numerically by three‐dimensional Lattice Boltzmann Method (LBM) at a pore scale in a non‐uniform flow field. The authors proposed an aperture‐related dilution index to quantify the local dilution process in the different aperture regions. The results showed that the fluctuation of the compound spreading caused by the flow fluctuation depended on both the aqueous diffusivity and the frequency of the flow fluctuation. The flow fluctuation increased remarkably the original dilution index when the aqueous diffusivity of the miscible compound was relatively low. However, the analysis of the aperture‐related dilution index showed that the degree of the dilution in smaller aperture regions was less than that in larger aperture regions, indicating that there was more incomplete dilution (mixing) in the smaller aperture region.
Chromosomal and Nuclear Alterations in the Root Tip Cells of Vicia faba Induced by Sodium Chloride
Authors: Souguir Dalila , Abd‐Alla Howaida Ibrahim , Hörmann Georg , Hachicha Mohamed 
Published: July 2017

ABSTRACT: Despite the well‐known toxic effect of chloride sodium (NaCl), only few studies analyze its genotoxic effect on crops. Micronucleus assay is an efficient tool for the measure of chromosomal DNA damages. Based on this test, the effects of salt on micronucleus induction, and on chromosome and nucleus changes, were investigated in Vicia faba root tips treated with NaCl (electrical conductivity = 25 dS/m) during 24 hours. V. faba meristematic cells showed a significant increase in the number of micronuclei compared with the control. Micronucleus size varied from small to large and appeared at different stages of mitosis. Moreover, different chromosomal aberrations like breaks, bridges, rings, vagrant, and lagging chromosomes, were observed in the metaphase, the anaphase, and the telophase. In addition, nuclear alterations in the interphase were characterized by the presence of binucleated cells, strap nuclei with lesions, hyperchromasia, buds, and nuclei with irregular shapes and lesions.