bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal Diagnosis of a KIDINS220 De Novo Heterozygous Variant in a Fetus With a Complex CNS Anomaly
Authors: Miremberg Hadas , Birnbaum Roee , Trigubov Dorin , Botvinik Adi , Yaron Yuval , Mory Adi , Malinger Gustavo , Haratz Karina Krajden 
Published: October 2024

ABSTRACTFollowing termination of pregnancy due to multiple brain malformations, a non‐consanguineous couple of Jewish descent sought genetic counseling. Brain malformations identified on neurosonogram included corpus callosum dysgenesis, abnormal brain stem morphology, abnormal cortical sulcation and hypertelorism. Trio exome sequencing revealed a heterozygous de novo likely pathogenic variant in KIDINS220 gene. Heterozygous variants in KIDINS220 have been linked to spastic paraplegia, intellectual disability, nystagmus, and obesity syndrome (SINO). Reports on prenatal findings are limited and primarily consist of cases of ventriculomegaly. We describe a more severe clinical presentation in a case with a heterozygous variant.
Titanium oxide hydrates as versatile polymer crosslinkers and molecular‐hybrid formers
Authors: Durbin Marlow M. , Votta Irene , Balzer Alex H. , Procházka Michal , Valentin Marian , Omastová Mária , Stingelin Natalie 
Published: October 2024

AbstractMolecular hybrid materials based on widely available polymers crosslinked with an inorganic species have received increasing interest for their unique property sets outside of the usual range of commodity plastics and/or nanocomposites. Here, we provide a mini‐review on molecular hybrids based on metal oxide hydrates—compounds that readily react with, for example, hydroxylated polymers to form inorganic:organic materials systems with many desirable features and properties. Focusing on titanium oxide hydrates, we discuss here that such molecular hybrids can exhibit a broad refractive index range in addition to an increased glass transition temperature, mechanical stiffness and swelling resistance in comparison to the neat polymer, which illustrates that such hybrid systems offer a new, low‐cost, robust and versatile functional materials platform with great promise for, for example, solution‐processed photonics, catalysts and antimicrobial coatings. Generally, our mini‐review seeks to provide a concise and accessible overview of titanium oxide hydrate:polymer hybrid systems, focusing on their unique properties and processability as well as their broad and largely untapped potential as functional materials. © 2024 The Author(s). Polymer International published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
CuIn (Se,Te)2 Absorbers With Bandgaps <1 eV for Bottom Cells in Tandem Applications
Authors: Weiss Thomas Paul , Sood Mohit , Vanderhaegen Aline , Siebentritt Susanne 
Published: October 2024

ABSTRACTThin‐film solar cells reach high efficiencies and have a low carbon footprint in production. Tandem solar cells have the potential to significantly increase the efficiency of this technology, where the bottom‐cell is generally composed of a Cu(In,Ga)Se2 absorber layer with bandgaps around 1 eV or higher. Here, we investigate CuIn(Se1 − xTex)2 absorber layers and solar cells with bandgaps below 1 eV, which will bring the benefit of an additional degree of freedom for designing current‐matched two‐terminal tandem devices. We report that CuIn(Se1 − xTex)2 thin films can be grown single phase by co‐evaporation and that the bandgap can be reduced to the optimum range (0.92–0.95 eV) for a bottom cell. From photoluminescence spectroscopy, it is found that no additional non‐radiative losses are introduced to the absorber when adding Te. However,
losses occur in the final solar cell due to non‐optimized interfaces. Nevertheless, a device with 9% power conversion efficiency is demonstrated with a bandgap of 0.97 eV and
, the highest efficiency so far for chalcopyrites with band gap <1 eV. Interface recombination is identified as a major recombination channel for larger Te contents. Thus, further efficiency improvements can be expected with improved absorber/buffer interfaces.
Open String Renormalization Group Flow as a Field Theory
Authors: Hristov Julius 
Published: October 2024

AbstractThis article shows that the integral flow‐lines of the RG‐flow of open string theory can be interpreted as the solitons of a Hořova–Lifshitz sigma‐model of open membranes. The authors argue that the effective background description of this model implies the g‐theorem of open string theory. Its close connection to boundary string field theory is described. Additionally, the study endows the Hilbert space of the open membrane with a graded non‐commutative, associative, cyclic algebra and construct an open membrane field theory, whose action measures the energy difference between different backgrounds in open string field theory. The authors use an identity‐based membrane field to proof Sen's conjecture. Finally, the ideas are applied to the topological string and it is shown that the membrane action is quantized in equivariant K‐theory of the moduli space of framed instantons.
(±)‐Catechins inhibit prehaustorium formation in the parasitic weed Phelipanche ramosa and reduce tomato infestation
Authors: Veronesi Christophe , Billard Estelle , Delavault Philippe , Simier Philippe 
Published: October 2024

AbstractBACKGROUNDPhelipanche ramosa L. (Pomel) is a noxious parasitic weed in field and vegetable crops in Mediterranean countries. Control of this pest is complex and far from being achieved, and new environmentally‐friendly strategies are being sought. The present study evaluates the possibility of using (±)‐catechins as a natural herbicide against broomrapes.RESULTSThe results show that (±)‐catechins have no effect on GR24‐induced germination over a wide concentration range (10−4 to 10−10 m), nor on radicle elongation after germination, but strongly inhibit, at 10−4 and 10−5 m, prehaustorium formation in response to the haustorium‐inducing factor, cis/trans‐zeatin. Accordingly, pot experiments involving the supplies of 10−5 m of (±)‐catechins to tomato plants infested or not with P. ramosa demonstrate that (±)‐catechins do not influence growth of non‐parasitized tomato plants and prevent heavy infestation by strongly reducing parasite attachments and inducing parasite necrosis once they are attached.CONCLUSIONThis study points the potential use of (±)‐catechins for parasitic weed control. It raises also the question of the mechanisms involved in the inhibition of prehaustorium formation and the necrosis of parasite attachments in response to (±)‐catechins application. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
A new adaptive EWMA chart for two‐parameter exponential distribution based on type‐II censored data
Authors: Munir Waqas 
Published: October 2024

AbstractIn this article, we propose a new adaptive exponentially weighted moving average (AEWMA) chart for monitoring the joint shifts in the location and scale parameters of the two‐parameter exponential distribution, namely the AEWMA‐II chart. A key feature of the proposed chart is its straightforward post‐signal diagnostics. The Monte Carlo simulation method is used to compute the steady‐state run‐length profiles of the proposed chart. The run‐length properties include the average run‐length and standard deviation of the run‐length. Through a comprehensive run‐length comparison, it is found that the AEWMA‐II chart performs better than the existing AEWMA chart. Moreover, with post‐signal diagnostics, the proposed chart also surpasses the existing chart. Finally, a real dataset is applied to illustrate the excellent performance and practical application of the proposed chart.
Influence of climate on soil viral communities in Australia on a regional scale
Authors: Bi Li , He Zi‐Yang , Nguyen Bao Anh Thi , Chan Lok Hang , Na Shuo , He Ji‐Zheng , Hu Hang‐Wei 
Published: October 2024

AbstractViruses play a crucial role in regulating microbial communities and ecosystem functioning. However, the biogeographic patterns of viruses and their responses to climate factors remain underexplored. In this study, we performed viral size fraction metagenomes on 108 samples collected along a 2600 km transect across Australia, encompassing distinct climate conditions. A total of 14,531 viral operational taxonomic units were identified. Climate factors had a greater influence than edaphic and biotic factors on driving the alpha diversity of viral communities. The strongest relationship was observed between mean annual temperature and the diversity of viral communities. Moreover, climate factors, particularly aridity index, were the primary drivers of viral community structure. Overall, these findings underscore the pivotal role of climate factors in shaping viral communities and have implications for understanding how climate change influences soil viral ecology.
The Role of Alkyl Chains in the Thermoresponse of Supramolecular Network
Authors: Scherb Sebastian , Hinaut Antoine , Gu Yanwei , Vilhena J.G. , Pawlak Rémy , Song Yiming , Narita Akimitsu , Glatzel Thilo , Müllen Klaus , Meyer Ernst 
Published: October 2024

AbstractSupramolecular materials provide a pathway for achieving precise, highly ordered structures while exhibiting remarkable response to external stimuli, a characteristic not commonly found in covalently bonded materials. The design of self‐assembled materials, where properties could be predicted/design from chemical nature of the individual building blocks, hinges upon our ability to relate macroscopic properties to individual building blocks – a feat which has thus far remained elusive. Here, a design approach is demonstrated to chemically engineer the thermal expansion coefficient of 2D supramolecular networks by over an order of magnitude (\boldmath 120 to \boldmath 1000 × 10−6 K−1). This systematic study provides a clear pathway on how to carefully design the thermal expansion coefficient of a 2D molecular assembly. Specifically, a linear relation has been identified between the length of decorating alkyl chains and the thermal expansion coefficient. Counter‐intuitively, the shorter the chains the larger is the thermal expansion coefficient. This precise control over thermo‐mechanical properties marks a significant leap forward in the de‐novo design of advanced 2D materials. The possibility to chemically engineer their thermo‐mechanical properties holds promise for innovations in sensors, actuators, and responsive materials across diverse fields.
Li–Sb Alloy Formation Strategy to Improve Interfacial Stability of All‐Solid‐State Lithium Batteries
Authors: Dandena Berhanu Degagsa , Su Wei‐Nien , Tsai Dah‐Shyang , Nikodimos Yosef , Taklu Bereket Woldegbreal , Bezabh Hailemariam Kassa , Desta Gidey Bahre , Yang Sheng‐Chiang , Lakshmanan Keseven , Sheu Hwo‐Shuenn , Wang Chia‐Hsin , Wu She‐Huang , Hwang Bing Joe 
Published: October 2024

AbstractThe solid electrolyte is anticipated to prevent lithium dendrite formation. However, preventing interface reactions and the development of undesirable lithium metal deposition during cycling are difficult and remain unresolved. Here, to comprehend these occurrences better, this study reports an alloy formation strategy for enhanced interface stability by incorporating antimony (Sb) in the lithium argyrodite solid electrolyte Li6PS5Cl (LPSC‐P) to form Li–Sb alloy. The Li–Sb alloy emergence at the anodic interface is crucial in facilitating uniform lithium deposition, resulting in excellent long‐term stability, and achieving the highest critical current density of 14.5 mA cm−2 (among the reported sulfide solid electrolytes) without lithium dendrite penetration. Furthermore, Li–Sb alloy formation maintain interfacial contact, even, after several plating and stripping. The Li–Sb alloy formation is confirmed by XRD, Raman, and XPS. The work demonstrates the prospect of utilizing alloy‐forming electrolytes for advanced solid‐state batteries.
The Influence of Yeast Inoculated on the Structural and Physicochemical Properties of Wheat Starch during Ganmianpi Fermentation
Authors: Luo Yueping , Qi Shanshan , Mu Tingting , He Yuanchen , Luo Min , Zhang Youe , Han Lin , He Caian , Wang Min 
Published: October 2024

AbstractGanmianpi is a traditional snack in China that has traditionally been produced through natural fermentation of wheat starch slurry. However, natural fermentation occurs spontaneously and lacks control, thereby an alternative yeast‐inoculated fermentation method is proposed for the industrialization of Ganmianpi production. This study aims to investigate the impact of yeast‐inoculated fermentation on the structural and physicochemical properties of wheat starch and elucidate the underlying mechanism. The findings reveal that yeast fermentation significantly affects the properties of wheat starch, varying with the fermentation time. Yeast‐inoculated fermentation leads to surface erosion of the starch granules and a significant reduction in amylose content, double helicity, gelatinization enthalpy, and relative crystallinity of wheat starch. Specially, yeast‐inoculated fermentation alters starch chain proportions, with a decrease in chain A and an increase in chains B1, B2, and B3. Ganmianpi produced from wheat starch exhibits decreased hardness, springiness, and chewiness, and sensory evaluation suggests an optimal fermentation time of 18 h for Ganmianpi production. Overall, this study provides valuable theoretical support for the industrial production of Ganmianpi and promotes the standardized production of fermented starch‐based foods.
Hypoxia‐Associated GPNMB+ Macrophages Promote Malignant Progression of Colorectal Cancer and Its Related Risk Signature Are Powerful Predictive Tool for the Treatment of Colorectal Cancer Patients
Authors: Zhang Junli , Hu Shangshang , Jin Xinxin , Zheng Yiwen , Yu Lianchen , Ma Junrao , Gu Biao , Wang Fen , Wu Wenjuan 
Published: October 2024

ABSTRACTColorectal cancer (CRC) is a highly malignant tumor with hypoxia being a crucial feature during its progression. This study utilized multiple independent CRC cohorts for bioinformatics analysis and in vitro experiments to investigate the role of hypoxia‐related subgroups in CRC. Machine learning was employed to construct risk features associated with this subgroup and further explore its therapeutic value in CRC. The study identified the GPNMB+ Macrophage (GPNMB+ Macr) subgroup as most relevant to hypoxia. GPNMB+ Macr showed significantly higher infiltration in tumor tissues compared to non‐tumor tissues, increasing with CRC stage. High infiltration of GPNMB+ Macr was associated with poor prognosis in terms of overall and recurrence‐free survival in CRC patients. GPNMB+ Macrophages exhibit M2‐like characteristics and have the ability to promote 5‐FU resistance, proliferation, and metastasis of CRC cells. The study developed the Hypoxia‐Related Macrophage Risk Score (HMRS), which not only served as an independent prognostic factor for CRC patients but also demonstrated robust prognostic performance compared to 84 previously published prognostic features. Patients with low HMRS were sensitive to fluorouracil, oxaliplatin (FOLFOX), and anti‐PD‐1 immunotherapy, while those with high HMRS showed resistance. Additionally, HMRS was identified as an independent prognostic factor in other digestive tract tumors (hepatocellular carcinoma, pancreatic cancer, esophageal cancer, and gastric cancer), indicating potential extrapolation to other tumor types. In conclusion, GPNMB+ Macr promotes the malignant progression of CRC, and HMRS serves as a powerful predictive tool for prognosis, chemotherapy, and immunotherapy in CRC patients, aiding in improving the quality of survival.
Attenuating susceptibility to ascites in cold‐stressed broiler chickens fed canola meal‐based diets by supplementing arginine or guanidinoacetic acid, either alone or in combination with phenylalanine
Authors: Delfani Negin , Daneshyar Mohsen , Farhoomand Parviz , Payvastegan Sina , Alijoo Younes Ali , Najafi Gholamreza 
Published: October 2024

AbstractObjectiveThe purpose of this study was to determine the effects of dietary supplementation of arginine (ARG) or guanidinoacetic acid (GAA), with or without phenylalanine (PHE), on the ascites susceptibility in the cold‐stressed broilers fed canola meal (CM)‐based diet.MethodA total of 450 one‐day‐old male broiler chicks were randomly allocated to 30 floor pens with 6 replications for each of the 5 treatments. The dietary treatments were as follows: CM‐based diet (control), CM‐based diet + 2.57 g/kg ARG, CM‐based diet + 1.8 g/kg GAA, CM‐based diet + 2.57 g/kg ARG + 1.5 g/kg PHE and CM‐based diet + 1.8 g/kg GAA + 1.5 g/kg PHE. The groups experienced cold stress induction starting at 32°C on day one, with gradual reductions to 15°C on days 21. The temperature was then held at 15°C for the remainder of the experiment.ResultsThe supplements ARG + PHE and GAA + PHE resulted in improved feed conversion ratios (FCR) when compared to the control group. In comparison with the control group, supplementation of ARG and ARG + PHE decreased the ascites mortality by increasing the plasma nitric oxide level (NO), blood O2 partial pressure, blood O2 saturation (SO2), and decreasing the blood CO2 partial pressure (PCO2) and right ventricle to total ventricle (RV:TV) ratio. Supplementation of GAA and GAA + PHE also declined ascites mortality by reducing blood PCO2 while increasing blood SO2 and plasma NO levels. Although plasma corticosterone level and RV:TV ratio were similar between the GAA and control groups, adding GAA + PHE significantly reduced both compared to the control group.ConclusionIn summary, supplementing cold‐stressed broiler chicken diets with 2.57 g/kg ARG may alleviate hypertension. Additionally, 1.8 g/kg GAA proves to be an effective substitute for dietary ARG in low‐ARG diets, alleviating adverse effects from cold stress. Proper PHE formulation, at 1.5 g/kg in this study, is crucial when using ARG and GAA supplements.
First molecular diagnosis of the human pathogen Rickettsia raoultii and other spotted fever group rickettsiae in Sudanese ixodid ticks from domestic ruminants
Authors: Eisawi Nagwa , Ahmed Jabbar , Bakheit Mohammed A. , Hassan Dina A. , Hussien Mohammed O. , El Hussein Abdel Rahim M. 
Published: October 2024

AbstractBackgroundRickettsial infections are often neglected and poorly recognized by physicians in many tropical and subtropical regions. Despite a number of recent reports describing rickettsial diseases in new locations and the discovery of new rickettsiae, medical science and research have largely neglected the diagnosis and antimicrobial treatment of rickettsial infections in subtropical and tropical areas; thus, much remains to be discovered. This study aimed to detect and characterize spotted fever group (SFG) rickettsiae in ixodid ticks infesting domestic ruminants in Khartoum State.MethodsPolymerase chain reaction targeting both genes that encode for citrate synthase (gltA) and outer membrane protein (ompA) was performed for the presence of SFG rickettsia followed by sequence and phylogenetic analysis.ResultsOf the 202 ticks examined for the presence of SFG rickettsia, gltA gene was detected in 4 samples (2%). Furthermore, gltA‐positive samples were used to amplify the ompA gene, in which only two samples yielded positive results. Sequence and phylogenetic analysis of the positive samples revealed four different species of SFG rickettsiae: Rickettsia aeschlimannii, Rickettsia rhipicephali, Rickettsia massiliae and Rickettsia raoultii.ConclusionsThese results indicated the presence of SFG rickettsia in Sudanese ticks. This also indicates that humans have an opportunity to acquire these infections. It is important to keep in mind the need for careful consideration of rickettsial infections in individuals with a fever of unknown origin.
Evaluation of thiol/disulphide and oxidant–antioxidant status of dairy cows in periparturient and post‐partum period
Authors: Balkan Burcu Menekse , Meral Ogunc , Cetintav Bekir , Ozkurt Guzin , Balkan Ali Burak , Sel Tevhide 
Published: October 2024

AbstractBackgroundThiol/disulphide homeostasis (TDH) has a critical role in many cellular activities such as antioxidant protection. Alterations of oxidative stress in the transition period play an important role in development of some diseases and disorders in dairy cows.ObjectivesThe purpose of this study is to assess the total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), total thiol, native thiol, disulphide and lipid profile in Simmental and Montofon dairy cows (aged 2–3) before and after calving.MethodsBlood samples were collected 233–280 days of pregnancy and the 30 days of post‐partum. Serum total thiol, native thiol and disulphide levels were determined as well as TAS, TOS and paraoxonase‐1 (PON‐1) levels were measured using colorimetric assays. Triglycerides (TG), total cholesterol, HDL cholesterol and LDL cholesterol levels were measured with an automatic analyser.ResultsTotal thiol (p = 0.038) and disulphide (p = 0.015) levels were higher after calving compare to pregnancy in Montofon. TAS was found lower (p < 0.001), and OSI was higher in both breeds (Montofon p = 0.012, Simmental p = 0.028) after calving than in pregnancy. When compared between pregnancy and after calving levels in the same breed, HDL was found to be higher after calving (p < 0.001) and TG was lower after calving (p = 0.020) in Montofon. PON (p = 0.090), HDL (p < 0.001) and cholesterol levels were found higher (p < 0.001) and TG level was lower (p < 0.001) after calving in Simmental.ConclusionsAccording to our results, we observed different responses between two breeds before and after calving. There are few studies about TDH in animal research, and this is the first study in the literature that evaluates the TDH along with oxidative stress and lipid profiles in dairy cows in the periparturient and post‐partum period.
Effects of dietary digestible lysine levels in breeding Japanese quails on productive and reproductive performance, egg quality, blood metabolites and immune responses
Authors: Omary Mohammad Amin , Zarghi Heydar , Hassanabadi Ahmad 
Published: October 2024

AbstractBackgroundThe vegetable‐based diet alone does not provide the lysine (Lys) needed to maximize poultry productive performance.ObjectivesThis experiment aimed to evaluate the effects of dietary digestible Lys (dLys) level on productive and reproductive performance, egg quality, blood metabolites and immune responses in breeding Japanese quails (Coturnix japonica).MethodsThe experiment was conducted in a completely randomized design with 6 treatments, 5 replicates and 15 (12 females and 3 meals) 10‐week‐old breeding Japanese quails each. A basal diet was formulated to meet nutritional requirements of breeding quails except dLys. The basal diet was supplemented with graded (+0.82 g/kg) levels of l‐Lys‐HCl, corresponding to dietary dLys levels of 0.690%, 0.755%, 0.820%, 0.885%, 0.950% and 1.015%. The experiment lasted for 12 weeks, which was divided into 3‐4‐week periods.ResultsSignificant differences were observed for egg production (EP), egg mass (EM) and feed efficiency (FE) in response to increasing dietary dLys concentration with quadratic trends. The highest traits were observed in the birds fed with a diet containing 0.885% dLys. However, feed intake, egg quality, reproductive performance, blood metabolites and immune responses against sheep red blood cell inoculation were not significantly affected by increasing dietary dLys concentrations. The dLys requirements during 11–14, 15–18, 19–22 and 11–22 (overall) weeks of age for optimal EP, EM and FE, based on the quadratic broken‐line regression analysis, were estimated 272, 265, 250 and 266; 293, 285, 264 and 279; and 303, 294, 281 and 293 mg/bird/day, respectively.ConclusionsThe dLys requirements vary depending on the EP phase and the trait being optimized. The estimated dLys requirement for FE was higher than those for EP and EM. During the peak stage of the first laying cycle, the dietary dLys level of 0.932% and a daily intake of 303 mg dLys/bird are sufficient for optimal performance.