bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole-Genome Shotgun Sequencing and Annotation of Mycobacterium tuberculosis MTBR1/09 Isolated from a Sputum Sample in Malaysia
Authors: Issa Rahizan , Seradja Valentinus H. , Abdullah Mohd Khairul Hafizi , Abdul Hatijah 
Published: June 2016

ABSTRACT

This is a report of an annotated genome sequence of
Mycobacterium tuberculosis
MTBR1/09. The organism was isolated from a sputum sample from a male patient in Malaysia.
Annotated Whole-Genome Shotgun Sequence of Mycobacterium tuberculosis MTBR2/09 Isolated from a Sputum Sample in Malaysia
Authors: Issa Rahizan , Seradja Valentinus H. , Abdullah Mohd Khairul Hafizi , Abdul Hatijah 
Published: June 2016

ABSTRACT

Mycobacterium tuberculosis
MTBR2/09 was isolated from a sputum sample from a male patient in Malaysia. This is a report of an annotated genome sequence of
M. tuberculosis
MTBR2/09.
Annotated Sequence of Mycobacterium tuberculosis MTBR3/09 Isolated from a Sputum Sample in Malaysia
Authors: Issa Rahizan , Seradja Valentinus H. , Abdullah Mohd Khairul Hafizi , Abdul Hatijah 
Published: June 2016

ABSTRACT

This is a report of the annotated genome sequence of
Mycobacterium tuberculosis
MTBR3/09. The organism was isolated from a sputum sample in Malaysia.
Genome Sequence of
Vaccinia virus
Strain Lister-Butantan, a Lister Vaccine Variant Used during a Smallpox Eradication Campaign in Brazil
Authors: Assis Felipe , Trindade Giliane , Drumond Betânia , Frace Mike , Sammons Scott , Emerson Ginny , Li Yu , Carroll Darin , Batra Dhwani , Abrahão Jonatas , Kroon Erna 
Published: June 2016

ABSTRACT

Here, we report the 187.8-kb genome sequence of
Vaccinia virus
Lister-Butantan, which was used in Brazil during the WHO smallpox eradication campaign. Its genome showed an average similarity of 98.18% with the original Lister isolate, highlighting the low divergence among related
Vaccinia virus
vaccine strains, even after several passages in animals and cell culture.
Complete Genome Sequence of Dyella thiooxydans ATSB10, a Thiosulfate-Oxidizing Bacterium Isolated from Sunflower Fields in South Korea
Authors: Hwangbo Kyeong , Um Yurry , Chung Hee , Yoo Jemin , Kim Ki Yoon , Madhaiyan Munusamy , Sa Tong Min , Lee Yi 
Published: June 2016

ABSTRACT

Dyella thiooxydans
ATSB10 (KACC 12756
T
= LMG 24673
T
) is a thiosulfate-oxidizing bacterium isolated from rhizosphere soils of sunflower plants. In this study, we completely sequenced the genome of
D. thiooxydans
ATSB10 and identified the genes involved in thiosulfate oxidation and the metabolism of aromatic intermediates.
What are the cost savings associated with providing access to specialist care through the Champlain BASE eConsult service? A costing evaluation
Authors: Liddy Clare , Drosinis Paul , Deri Armstrong Catherine , McKellips Fanny , Afkham Amir , Keely Erin 
Published: June 2016

ObjectiveThis study estimates the costs and potential savings associated with all eConsult cases completed between 1 April 2014 and 31 March 2015.DesignCosting evaluation from the societal perspective estimating the costs and potential savings associated with all eConsults completed during the study period.SettingChamplain health region in Eastern Ontario, Canada.PopulationPrimary care providers and specialists registered to use the eConsult service.Main outcome measuresCosts included (1) delivery costs; (2) specialist remuneration; (3) costs associated with traditional (face-to-face) referrals initiated as a result of eConsult. Potential savings included (1) costs of traditional referrals avoided; (2) indirect patient savings through avoided travel and lost wages/productivity. Net potential societal cost savings were estimated by subtracting total costs from total potential savings.ResultsA total of 3487 eConsults were completed during the study period. In 40% of eConsults, a face-to-face specialist visit was originally contemplated but avoided as result of eConsult. In 3% of eConsults, a face-to-face specialist visit was not originally contemplated but was prompted as a result of the eConsult. From the societal perspective, total costs were estimated at $207 787 and total potential savings were $246 516. eConsult led to a net societal saving of $38 729 or $11 per eConsult.ConclusionsOur findings demonstrate potential cost savings from the societal perspective, as patients avoided the travel costs and lost wages/productivity associated with face-to-face specialist visits. Greater savings are expected once we account for other costs such as avoided tests and visits and potential improved health outcomes associated with shorter wait times. Our findings are valuable for healthcare delivery decision-makers as they seek solutions to improve care in a patient-centred and efficient manner.
Patients’ experiences of deep brain stimulation for Parkinson's disease: a qualitative systematic review and synthesis
Authors: Mathers J , Rick C , Jenkinson C , Garside R , Pall H , Mitchell R , Bayliss S , Jones L L 
Published: June 2016

ObjectiveTo review and synthesise qualitative research studies that have explored patients’ experience of deep brain stimulation (DBS) in advanced Parkinson's disease (PD).DesignSystematic review and meta-synthesis of 7 original papers, using metaethnography.SettingStudies conducted in Denmark, France and Sweden.Participants116 patients who had undergone DBS and 9 spouses of patients.ResultsPrior to surgery, the experience of advancing PD is one of considerable loss and a feeling of loss of control. There are significant hopes for what DBS can bring. Following surgery, a sense of euphoria is described by many, although this does not persist and there is a need for significant transitions following this. We suggest that normality as a concept is core to the experience of DBS and that a sense of control may be a key condition for normality. Experience of DBS for patients and spouses, and of the transitions that they must undertake, is influenced by their hopes of what surgery will enable them to achieve, or regain (ie, a new normality).ConclusionsThere is a need for further qualitative research to understand the nature of these transitions to inform how best patients and their spouses can be supported by healthcare professionals before, during and after DBS. In assessing the outcomes of DBS and other treatments in advanced PD, we should consider how to capture holistic concepts such as normality and control. Studies that examine the outcomes of DBS require longer term follow-up.
Review of how we should define (and measure) adherence in studies examining older adults' participation in exercise classes
Authors: Hawley-Hague H , Horne M , Skelton D A , Todd C 
Published: June 2016

Exercise classes provide a range of benefits to older adults, reducing risk of illness, promoting functional ability and improving well-being. However, to be effective and achieve long-term outcomes, exercise needs to be maintained. Adherence is poor and reporting of adherence differs considerably between studies.ObjectiveTo explore how adherence to exercise classes for older people is defined in the literature and devise a definition for pooling data on adherence in future studies.DesignMethodological review of the approaches used to measure adherence.MethodsA review of the literature was carried out using narrative synthesis, based on systematic searches of MEDLINE, EMBASE, CINAHL and PsychINFO. 2 investigators identified eligible studies and extracted data independently.Results37 papers including 34 studies were identified. 7 papers (7 studies) defined adherence as completion (retention). 30 papers (27 studies) identified adherence using attendance records. 12 papers (11 studies) based adherence on duration of exercise and 5 papers (4 studies) specified the intensity with which participants should exercise. Several studies used multiple methods.ConclusionsThere was little consensus between studies on how adherence should be defined, and even when studies used the same conceptual measure, they measured the concept using different approaches and/or had different cut-off points. Adherence related to health outcomes requires multiple measurements, for example, attendance, duration and intensity. It is important that future studies consider the outcome of the intervention when considering their definition of adherence, and we recommend a series of definitions for future use.
Characteristics of breakthrough cancer pain and its influence on quality of life in an international cohort of patients with cancer
Authors: Hjermstad Marianne Jensen , Kaasa Stein , Caraceni Augusto , Loge Jon H , Pedersen Tore , Haugen Dagny Faksvåg , Aass Nina 
Published: June 2016

ObjectivesBreakthrough cancer pain (BTP) represents a treatment challenge. Objectives were to examine the prevalence and characteristics of BTP in an international sample of patients with cancer, and to investigate the relationship between BTP and quality of life (QoL).MethodsThis was an observational cross-sectional multicentre study. Participating patients completed self-report questionnaires on a touch-screen laptop computer, including the Brief Pain Inventory, Alberta Breakthrough Pain Assessment Tool (ABPAT) and European Organisation for Research and Treatment of Cancer 30-item Core Quality of Life Questionnaire (EORTC QLQ-C30). The study was performed in 17 centres in 8 countries and involved 4 languages (Norwegian, Italian, German and English).ResultsRecords from a convenience sample of 978 patients with advanced cancer were analysed; mean age was 62.2 years, 48.3% were women and 84.4% had metastatic disease. A total of 296 patients (30%) had no pain, defined as worst pain in the past 24 hours <1 on a 0–10 scale. Of the 682 patients with a pain score ≥1, 393 (58%) reported no BTP on the screening item, while 289 (30%) confirmed flare ups of BTP. Patients with BTP reported significantly higher pain intensity scores (<0.001) than patients without BTP; 57.1% of patients rated BTP at its worst as being severe: ≥7 on a 0–10 scale. Time from onset to peak intensity was <10 min for 42.9%, and average time to pain relief was 27.1 min. BTP was commonly triggered by medication wearing off (28%). Patients with BTP had significantly worse mean outcomes on 10 of 15 functional and symptom scales of the EORTC QLQ-C30 (<0.001). Severe pain intensity in the last week was a powerful predictor of BTP (OR 4.1) and poor QoL (OR 1.9).ConclusionsBTP is highly prevalent with prolonged episodes despite analgaesics, and has a pervasive impact on QoL. Patients reporting high pain intensity should be carefully evaluated for BTP and efficacy of analgaesic treatment, to provide optimal pain management and improve QoL.Trial registration numberNCT00972634; Results.
Paternal education and adverse birth outcomes in Canada
Authors: Shapiro Gabriel D , Bushnik Tracey , Sheppard Amanda J , Kramer Michael S , Kaufman Jay S , Yang Seungmi 
Published: June 2016

BackgroundResearch on predictors of adverse birth outcomes has focused on maternal characteristics. Much less is known about the role of paternal factors. Paternal education is an important socioeconomic marker that may predict birth outcomes over and above maternal socioeconomic indicators.MethodsUsing data from the 2006 Canadian Birth-Census Cohort, we estimated the associations between paternal education and preterm birth, small-for-gestational-age (SGA) birth, stillbirth and infant mortality in Canada, controlling for maternal characteristics. Binomial regression was used to estimate risk ratios and risk differences for adverse birth outcomes associated with paternal education, after controlling for maternal education, age, marital status, parity, ethnicity and nativity.ResultsA total of 131 285 singleton births were included in the present study. Comparing the lowest to the highest paternal education category, adjusted risk ratios (95% CIs) were 1.22 (1.10 to 1.35) for preterm birth, 1.13 (1.03 to 1.23) for SGA birth, 1.92 (1.28 to 2.86) for stillbirth and 1.67 (1.01 to 2.75) for infant mortality. Consistent patterns of associations were observed for absolute risk differences.ConclusionsOur study suggests that low paternal education increases the risk of adverse birth outcomes, and especially of fetal and infant mortality, independently from maternal characteristics.
Ultra-distal access of the M1 segment with the 5 Fr Navien distal access catheter in acute (anterior circulation) stroke: is it safe and efficient?
Authors: Janssen H , Killer-Oberpfalzer M , Patzig M , Buchholz G , Lutz J 
Published: June 2016

Background and aimThe importance of mechanical thrombectomy in acute stroke treatment has grown over recent years. Mechanical thrombectomy comprises many different techniques. Technical improvements in the catheter material have led to the development of large-bore distal access catheters which can enter tortuous intracranial vessels. This has promising applications for endovascular stroke treatment. This study evaluated the safety and success rate of ultra-distal access of the middle cerebral artery (MCA) M1 segment with the 5 Fr Navien 58 distal access catheter in the treatment of acute stroke in combination with stent retrievers.MethodsWe retrospectively analyzed 81 patients with an acute stroke of the anterior circulation in whom ultra-distal access to the M1 segment was carried out using the Navien 58 catheter with an anchoring technique with a stent retriever for mechanical thrombectomy. Technical complications, success rates of catheter placement, success rates of thrombectomy using the modified Thrombolysis In Cerebral Infarction (mTICI) score, and the procedure times were evaluated.ResultsUltra-distal access with the Navien 58 was successful in 75% (61/81) of cases. Recanalization success with a mTICI score of 2b and better was achieved in 83% overall (67/81), in 90% (55/61) of cases with successful ultra-distal access and in 60% (12/20) of cases without ultra-distal access. No severe adverse effects such as dissections or perforations occurred as a result of the ultra-distal catheter placement in the M1 segment. In 4% (3/81) of the cases a reversible MCA vasospasm occurred.ConclusionsUltra-distal placement of the Navien 58 distal access catheter into the M1 segment in acute anterior circulation stroke can be achieved consistently, is safe in practice, and results in good recanalization success rates.
Survey of the use of domperidone and the association with QTc prolongation in general practice
Authors: Ioannou Adam , Jain Alka , Kassianos George , Missouris Constantinos 
Published: June 2016

AbstractPurpose of the studyDomperidone is associated with QTc prolongation, predisposing to the development of ventricular arrhythmias. In 2014, The Medicines and Healthcare Regulatory Agency (MHRA) recommended restricting its use. We assessed whether these recommendations have been implemented in a general practice.Study designWe conducted a prospective study using the general practitioner (GP) computer database on patients who had at least one repeat prescription for domperidone in 12 months. Data were presented to the doctors and the survey was repeated 7 months later.ResultsSixty-four patients (mean age 61.3±16.4 years) were identified who had received at least one repeat prescription of domperidone. Twenty patients were being prescribed over the recommended daily dose. Nineteen patients were coprescribed medications known to prolong the QTc interval and two CYP3A4 inhibitors. The repeat survey performed 7 months later demonstrated a 70% reduction in the number of patients prescribed domperidone to a total of 19 (three patients prescribed above the recommended dose) none of which had a history of cardiac disease or were being coprescribed drugs known to prolong the QTc interval.ConclusionsFollowing the publication of the MHRA recommendations and presentation of our initial survey, there has been a significant reduction in the number of patients treated with domperidone and those coprescribed drugs known to prolong the QTc interval. We suggest that regular review of GP practice database should be performed to identify those patients prescribed domperidone and at risk of life-threatening arrhythmias and measures taken to use alternative pharmacological agents.
A pragmatic approach to abstract the excavation damaged zone around tunnels of a geological radioactive waste repository: application to the HG-A experiment in Mont Terri
Authors: Alcolea Andrés , Kuhlmann Uli , Marschall Paul , Lisjak Andrea , Grasselli Giovanni , Mahabadi Omid , de La Vaissière Rémi , Leung Helen , Shao Hua 
Published: June 2016

Abstract

The excavation damaged zone (EDZ) around the backfilled tunnels of a geological repository represents a possible release path for radionuclides, corrosion and degradation gases that needs to be adequately addressed by safety assessment (SA) modelling tools. The hydromechanical phenomena associated with the creation and temporal evolution of the EDZ are of high complexity, precluding detailed representations of the EDZ in conventional SA. Thus, simplified EDZ models mimicking the safety-relevant features of the EDZ are required. In this context, a heuristic modelling approach has been developed to represent the creation and evolution of the EDZ in an abstracted and simplified manner. The key features addressed are the stochastic character of the excavation-induced fracture network and the self-sealing processes associated with the re-saturation after backfilling of the tunnels. The approach has been applied to a range of generic repository settings to investigate the impact of repository depth and
in situ
conditions on the hydraulic significance of the EDZ after repository closure. The model has been benchmarked with a dataset from a self-sealing experiment at the Mont Terri underground rock laboratory (URL), demonstrating the ability of the approach to mimic the evolution of the hydraulic significance of the EDZ during the re-saturation phase.
Promoting health literacy in the classroom
Authors: Bruselius-Jensen Maria , Bonde Ane Høstgaard , Christensen Julie Hellesøe 
Published: June 2016

Objective: Research has shown that developing health literacy in early life is critical to reducing lifestyle-related diseases, with schools being identified as central settings for this purpose. This paper examines how one classroom-based health educational programme, IMOVE, helped Danish primary school pupils develop health literacy related to physical activity. It discusses curriculum-integrated health education’s contribution to promoting health literacy. Design: Qualitative classroom observation. Setting: IMOVE was implemented in 12 school classes (grades 5–7) in four public schools in Copenhagen, Denmark, during the autumn and winter of 2013–2014. Participants numbered 281 pupils and nine teachers. Method: We used Nutbeam’s conceptualisation of health literacy as a theoretical framework to assess which levels of health literacy the programme would promote; we assessed these using data derived from 59 IMOVE lesson transcripts. Results: IMOVE primarily contributed to the development of functional health literacy by building a relational understanding between everyday practice and step numbers. We observed the presence of interactive health literacy in discussions about how pupils and teachers could change their daily practices. Only a limited number of discussions supported the development of critical health literacy. Conclusion: Our findings suggest that educators can successfully integrate health literacy development into classroom-based curriculum teaching, with pupils’ own step counts and associated reflections positively influencing learning. However, in this study, classroom teaching was limited to a focus on cognitive skills and only partially supported the development of more critical health literacy skills. Our findings call for further research into approaches to support classroom-based critical health literacy development.
Costs after hip fracture in independently living patients: a randomised comparison of three rehabilitation modalities
Authors: Lahtinen A , Leppilahti J , Vähänikkilä H , Harmainen S , Koistinen P , Rissanen P , Jalovaara P 
Published: June 2016

Objective:To evaluate costs and cost-effectiveness of physical and geriatric rehabilitation after hip fracture.Design:Prospective randomised study (mean age 78 years, 105 male, 433 female) in different rehabilitation settings: physically oriented (187 patients), geriatrically oriented (171 patients), and healthcare centre hospital (control, 180 patients).Main measures:At 12 months post-fracture, we collected data regarding days in rehabilitation, post-rehabilitation hospital treatment, other healthcare service use, number of re-operations, taxi use by patient or relative, and help from relatives.Results:Control rehabilitation (4945,2€) was significantly less expensive than physical (6609.0€, p=0.002) and geriatric rehabilitation (7034.7€ p<0.001). Total institutional care costs (primary treatment, rehabilitation, and post-rehabilitation hospital care) were lower for control (13,438.4€) than geriatric rehabilitation (17,201.7€, p<0.001), but did not differ between control and physical rehabilitation (15659.1€, p=0.055) or between physical and geriatric rehabilitation ( p=0.252). Costs of help from relatives (estimated as 30%, 50% and 100% of a home aid’s salary) with physical rehabilitation were lower than control ( p=0.016) but higher than geriatric rehabilitation ( p=0.041). Total hip fracture treatment costs were lower with physical (36,356€, 51,018€) than control rehabilitation (38,018€, 57,031€) at 50% and 100% of salary ( p=0.032, p=0.014, respectively). At one year post-fracture, 15D-score was significantly higher in physical rehabilitation group (0.697) than geriatric rehabilitation group (0.586, p=0.008) and control group (0.594, p=0.009).Conclusions:Considering total costs one year after hip fracture the treatment including physical rehabilitation is significantly more cost-effective than routine treatment. This effect could not be seen between routine treatment and treatment including geriatric rehabilitation.
Cerebral metabolism before and after external trigeminal nerve stimulation in episodic migraine
Authors: Magis Delphine , D’Ostilio Kevin , Thibaut Aurore , De Pasqua Victor , Gerard Pascale , Hustinx Roland , Laureys Steven , Schoenen Jean 
Published: June 2016

Background and aim A recent sham-controlled trial showed that external trigeminal nerve stimulation (eTNS) is effective in episodic migraine (MO) prevention. However, its mechanism of action remains unknown. We performed 18-fluorodeoxyglucose positron emission tomography (FDG-PET) to evaluate brain metabolic changes before and after eTNS in episodic migraineurs. Methods Twenty-eight individuals were recruited: 14 with MO and 20 healthy volunteers (HVs). HVs underwent a single FDG-PET, whereas patients were scanned at baseline, directly after a first prolonged session of eTNS (Cefaly®) and after three months of treatment (uncontrolled study). Results The frequency of migraine attacks significantly decreased in compliant patients ( N = 10). Baseline FDG-PET revealed a significant hypometabolism in fronto-temporal areas, especially in the orbitofrontal (OFC) and rostral anterior cingulate cortices (rACC) in MO patients. This hypometabolism was reduced after three months of eTNS treatment. Conclusion Our study shows that metabolic activity of OFC and rACC, which are pivotal areas in central pain and behaviour control, is decreased in migraine. This hypometabolism is reduced after three months of eTNS. eTNS might thus exert its beneficial effects via slow neuromodulation of central pain-controlling areas, a mechanism also previously reported in chronic migraine and cluster headache after percutaneous occipital nerve stimulation. However, this finding needs to be confirmed by further studies using a sham condition.