bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated Epigenomics Analysis Reveals a DNA Methylation Panel for Endometrial Cancer Detection Using Cervical Scrapings
Authors: Huang Rui-Lan , Su Po-Hsuan , Liao Yu-Ping , Wu Tzu-I , Hsu Ya-Ting , Lin Wei-Yu , Wang Hui-Chen , Weng Yu-Chun , Ou Yu-Che , Huang Tim Hui-Ming , Lai Hung-Cheng 
Published: August 2016

Abstract
Purpose: Endometrial cancer is a common gynecologic cancer whose incidence is increasing annually worldwide. Current methods to detect endometrial cancer are unreliable and biomarkers are unsatisfactory for screening. Cervical scrapings were reported as a potential source of material for molecular testing. DNA methylation is a promising cancer biomarker, but limited use for detecting endometrial cancer.
Experimental Design: We analyzed two methylomics databases of endometrioid-type endometrial cancer. Using nonnegative matrix factorization algorithm clustered the methylation pattern and reduced the candidate genes. We verified in pools DNA from endometrial cancer tissues and cervical scrapings, and validated in 146 cervical scrapings from patients with endometrioid-type endometrial cancer (n = 50), uterine myoma (n = 40), and healthy controls (n = 56) using quantitative methylation–specific PCR (QMSP). The logistic regression was used to evaluate the performance of methylation signal and gene combination.
Results: We filtered out 180 methylated genes, which constituted four consensus clusters. Serial testing of tissues and cervical scrapings detected 14 genes that are hypermethylated in endometrial cancer. Three genes, BHLHE22, CDO1, and CELF4, had the best performance. Individual genes were sensitivity of 83.7%–96.0% and specificity of 78.7%–96.0%. A panel comprising any two of the three hypermethylated genes reached a sensitivity of 91.8%, specificity of 95.5%, and odds ratio of 236.3 (95% confidence interval, 56.4–989.6). These markers were also applied to cervical scrapings of type II endometrial cancer patients, and detected in 13 of 14 patients.
Conclusions: This study demonstrates the potential use of methylated BHLHE22/CDO1/CELF4 panel for endometrial cancer screening of cervical scrapings. Clin Cancer Res; 23(1); 263–72. ©2016 AACR.
A "Revolta das Barcas": sobre silenciamento performativo e imaterialidade do protesto na (in)visibilidade contemporânea das periferias urbanas
Authors: Raposo Paulo 
Published: August 2016

Neste artigo pretendo pensar do ponto vista da antropologia da performance o cruzamento entre espaço público, performances políticas e mediatização. Através da leitura de uma revolta urbana espoletada em 1959 em Niterói, a Revolta das Barcas, propus aos participantes de um curso-oficina na Universidade Federal Fluminense, em Novembro de 2014, uma instalação-performativa para revisitar sua memória e, sobretudo, para a reatualizá-la de um ponto de vista político face aos conflitos recentes associados ao Movimento Passe Livre no Brasil. Começo por analisar um conjunto imagético de protestos recentes em Portugal, stados Unidos, Espanha e Brasil para explicitar traços semelhantes no modo de atuação dessas mobilizações políticas e na resposta dada pelo poder dominante. “Artivismo” emerge como conceito a explorar nos protestos políticos contemporâneos. Ao longo do artigo, tentarei sublinhar a sua performatividade ativista, seus efeitos de carnavalização e suas possíveis articulações entre repertórios e arquivos.
Relendo "A musicológica Kamayurá" de Rafael José de Menezes Bastos: 40 anos para além de uma antropologia sem música e de uma musicologia sem homem
Authors: Jacques Tatyana de Alencar 
Published: August 2016

A obra de Rafael José de Menezes Bastos A Musicológica Kamayurá está prestes a completar 40 anos. Inicialmente, foi apresentada como Dissertação de Mestrado em outubro de 1976, ao Programa de Pós-Graduação em Antropologia Social da Universidade de Brasília, orientada por Peter Silverwood-Cope, DavidPrice e Roque de Barros Laraia. Foi publicada pela primeira vez pela Fundação Nacional do Índio (FUNAI) em 1978, com tiragem limitada que se esgotou rapidamente e, conforme Anthony Seeger, “circulou de mão em mão” e foi “guardada como tesouro por aqueles que puderam obter seu próprio exemplar” (Seeger 1999, 13). Em 1999, a obra recebeu sua segunda edição, segundo Menezes Bastos, quase ipsis litteris em relação à primeira, publicada pela Editora da Universidade Federal de Santa Catarina, onde seu autor é professor desde 1984.
A musicológica Kamayurá - Entrevista com Rafael José de Menezes Bastos
Authors: Jacques Tatyana de Alencar 
Published: August 2016

https://vimeo.com/147721141
A Musicológica Kamayurá - Entrevista com Rafael José de Menezes Bastos
Na entrevista A Musicológica Kamayurá, o Professor Rafael José de Menezes Bastos nos fala de seus anos de formação e de suas primeiras experiências profissionais. Comenta sobre seus principais gurus intelectuais e sobre o contexto político que marca sua atividade profissional na FUNAI na década de 1960 e também os anos de seu Mestrado na Universidade de Brasília. Também são assunto dessa entrevista algumas das principais questões teórico-metodológicas que marcam o livro A Musicológica Kamayurá (1978), tais como a questão da metalinguagem musical e da importância do ritual na constituição dos sistemas musicais, temas que serão retomados em trabalhos posteriores do autor. Brasil, 2015, Colorido; 22 min Roteiro, edição e realização da entrevista Tatyana de Alencar Jacques Música: Índios Kamayurá Fotografias e gravações: Rafael José de Menezes Bastos Produção: Tatyana de Alencar Jacques e Ari Ghiggi Junior Realizada em Florianópolis, 18 de maio de 2015.
Randomized Comparison of High-Sensitivity Troponin Reporting in Undifferentiated Chest Pain Assessment
Authors: Chew Derek P. , Zeitz Christopher , Worthley Matthew , Grantham Hugh , Beltrame John , Arstall Margaret , Coates Penelope , Astley Carolyn , Quinn Stephen , Ratcliffe Julie , Horsfall Matthew , Aylward Philip G. 
Published: August 2016

Background—
High-sensitivity troponin T (hs-TnT) assays promise greater discrimination of evolving myocardial infarction, but the impact of unguided implementation on the effectiveness of care is uncertain.

Methods and Results—

We evaluated the impact of hs-TnT reporting on care and outcome among chest pain patients presenting to 5 emergency departments within a multicenter randomized trial. Patients were allocated to hs-TnT reporting (hs-report) or standard reporting (std-report; Roche Elecys). The primary end point was death and new or recurrent acute coronary syndrome by 12 months. A total of 1937 patients without ST-segment elevation were enrolled between July 2011 and March 2013. The median age was 61 (interquartile range, 48–74) years, and 46.3% were women. During the index hospitalization, 1466 patients (75.7%) had maximal troponin <30 ng/L within 24 hours. Randomization to hs-report format did not alter the admission rate (hs-report: 57.7% versus std-report: 58.0%;
P
=0.069). There was no difference in angiography (hs-report: 11.9% versus std-report: 10.9%;
P
=0.479). The hs-reporting did not reduce 12-month death or new/recurrent acute coronary syndrome in the overall population (hs-report: 9.7% versus std-report: 7.2% [hazard ratio, 0.83 (0.57–1.22);
P
=0.362]). However, among those with troponin levels <30 ng/L, a modest reduction in the primary end point was observed (hs-report: 2.6% versus std-report: 4.4%, [hazard ratio, 0.58; 95% confidence interval, 0.34–0.1.00;
P
=0.050).

Conclusions—
High-sensitivity troponin reporting alone is associated with only modest changes in practice. Clinical effectiveness in the adoption of high-sensitivity troponin may require close coupling with protocols that guide interpretation and care.

Clinical Trial Registration—

URL:
http://www.ANZCTR.org.au
. Unique identifier: ACTRN12611000879965.
Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin‐Deficient Hearts
Authors: Hammers David W. , Sleeper Margaret M. , Forbes Sean C. , Shima Ai , Walter Glenn A. , Sweeney H. Lee 
Published: August 2016

Background
Cardiomyopathy is a leading cause of mortality among Duchenne muscular dystrophy patients and lacks effective therapies. Phosphodiesterase type 5 is implicated in dystrophic pathology, and the phosphodiesterase type 5 inhibitor tadalafil has recently been studied in a clinical trial for Duchenne muscular dystrophy.

Methods and Results

Tadalafil was evaluated for the prevention of cardiomyopathy in the
mdx
mouse and golden retriever muscular dystrophy dog models of Duchenne muscular dystrophy. Tadalafil blunted the adrenergic response in
mdx
hearts during a 30‐minute dobutamine challenge, which coincided with cardioprotective signaling, reduced induction of μ‐calpain levels, and decreased sarcomeric protein proteolysis. Dogs with golden retriever muscular dystrophy began daily tadalafil treatment prior to detectable cardiomyopathy and demonstrated preserved cardiac function, as assessed by echocardiography and magnetic resonance imaging at ages 18, 21, and 25 months. Tadalafil treatment improved golden retriever muscular dystrophy histopathological features, decreased levels of the cation channel
TRPC
6, increased total threonine phosphorylation status of
TRPC
6, decreased m‐calpain levels and indicators of calpain target proteolysis, and elevated levels of utrophin. In addition, we showed that Duchenne muscular dystrophy patient myocardium exhibited increased
TRPC
6, m‐calpain, and calpain cleavage products compared with control human myocardium.

Conclusions

Prophylactic use of tadalafil delays the onset of dystrophic cardiomyopathy, which is likely attributed to modulation of
TRPC
6 levels and permeability and inhibition of protease content and activity. Consequently, phosphodiesterase type 5 inhibition is a candidate therapy for slowing the development of cardiomyopathy in Duchenne muscular dystrophy patients.
The Design of a Modern Information Technology Infrastructure to Facilitate Research-to-Operations Transition for NCEP’s Modeling Suites
Authors: Carson Laurie , Tallapragada Vijay 
Published: August 2016

AbstractNOAA/NCEP runs a number of numerical weather prediction (NWP) modeling suites to provide operational guidance to the National Weather Service field offices and service centers. A sophisticated infrastructure, which includes a complex set of software tools, is required to facilitate running these NWP suites. This infrastructure needs to be maintained and upgraded so that continued improvements in forecast accuracy can be achieved. This contribution describes the design of a robust NWP Information Technology Environment (NITE) to support and accelerate the transition of innovations to NOAA operational modeling suites.Through consultation with and at the request of the NOAA NCEP Environmental Modeling Center, a survey of segments of the national NWP community, and a review of selected aspects of the computational infrastructure of several modeling centers was conducted, which led to the following elements being considered as key for NITE: data management, source code management and build systems, suite definition tools, scripts, workflow management, experiment database, and documentation and training.The design for NITE put forth by the DTC would make model development by NOAA staff and their external collaborators more effective and efficient. It should be noted that NITE was not designed to work exclusively for a certain modeling suite; instead it transcends the current operational suites and is applicable to the expected evolution in NCEP systems. NITE is particularly important for community engagement in the Next-Generation Global Prediction System, which is expected to be an Earth modeling system including several components.
Seasonal and Intraseasonal Variability of Mesoscale Convective Systems over the South Asian Monsoon Region
Authors: Virts Katrina S. , Houze Robert A. 
Published: August 2016

Abstract
Seasonal and intraseasonal differences in mesoscale convective systems (MCSs) over South Asia are examined using A-Train satellites, a ground-based lightning network, and reanalysis fields. Premonsoon (April–May) MCSs occur primarily over Bangladesh and the eastern Bay of Bengal. During the monsoon (June–September), small MCSs occur over the Meghalaya Plateau and northeast Himalayan notch, while large and connected MCSs are most widespread over the Bay of Bengal. Monsoon MCSs produce less lightning and exhibit more extensive stratiform and anvil reflectivity structures in CloudSat observations than do premonsoon MCSs.
During the monsoon, Bay of Bengal and Meghalaya Plateau MCSs vary with the 30–60-day northward-propagating intraseasonal oscillation, while northeast Himalayan notch MCSs are associated with weak large-scale anomalies but locally enhanced CAPE. During intraseasonal active periods, a zone of enhanced large and connected MCSs, precipitation, and lightning extends from the northeastern Arabian Sea southeastward over India and the Bay of Bengal, flanked by suppressed anomalies. Spatial variability is observed within this enhancement zone: lightning is most enhanced where MCSs are less enhanced, and vice versa. Reanalysis composites indicate that Bay of Bengal MCSs are associated with monsoon depressions, which are frequent during active monsoon periods, while Meghalaya Plateau MCSs are most frequent at the end of break periods, as anomalous southwesterly winds strengthen moist advection toward the terrain. Over both regions, MCSs exhibit more extensive stratiform and anvil regions and less lightning when the large-scale environment is moister, and vice versa.
The Diurnal Cycle of Warm Season Rainfall over West Africa. Part I: Observational Analysis
Authors: Zhang Gang , Cook Kerry H. , Vizy Edward K. 
Published: August 2016

AbstractThis study provides an improved understanding of the diurnal cycle of warm season (June–September) rainfall over West Africa, including its underlying physical processes. Rainfall from the Tropical Rainfall Measuring Mission and atmospheric dynamics fields from reanalyses are used to evaluate the 1998–2013 climatology and a case study for 2006.In both the climatology and the 2006 case study, most regions of West Africa are shown to have a single diurnal peak of rainfall either in the afternoon or at night. Averaging over West Africa produces a diurnal cycle with two peaks, but this type of diurnal cycle is quite atypical on smaller space scales. Rainfall systems are usually generated in the afternoon and propagate westward, lasting into the night. Afternoon rainfall peaks are associated with an unstable lower troposphere. They occur either over topography or in regions undisturbed by nocturnal systems, allowing locally generated instability to dominate. Nocturnal rainfall peaks are associated with the westward propagation of rainfall systems and not generally with local instability. Nocturnal rainfall peaks occur most frequently about 3°–10° of longitude downstream of regions with afternoon rainfall peaks. The diurnal cycle of rainfall is closely associated with the timing of extreme rainfall events.
Skill Assessment of HF Radar–Derived Products for Lagrangian Simulations in the Bay of Biscay
Authors: Solabarrieta Lohitzune , Frolov Sergey , Cook Mike , Paduan Jeff , Rubio Anna , González Manuel , Mader Julien , Charria Guillaume 
Published: August 2016

AbstractSince January 2009, two long-range high-frequency (HF) radar systems have been collecting hourly high-spatial-resolution surface current data in the southeastern corner of the Bay of Biscay. The temporal resolution of the HF radar surface currents permits simulating drifter trajectories with the same time step as that of real drifters deployed in the region in 2009. The main goal of this work is to compare real drifter trajectories with trajectories computed from HF radar currents obtained using different methods, including forecast currents. Open-boundary modal analysis (OMA) is applied to the radar radial velocities and then a linear autoregressive model on the empirical orthogonal function (EOF) decomposition of an historical data series is used to forecast OMA currents. Additionally, the accuracy of the forecast method in terms of the spatial and temporal distribution of the Lagrangian distances between observations and forecasts is investigated for a 4-yr period (2009–12). The skills of the different HF radar products are evaluated within a 48-h window. The mean distances between real trajectories and their radar-derived counterparts range from 4 to 5 km for real-time and forecast currents after 12 hours of simulations. The forecast model improves persistence (i.e., the simulations obtained by using the last available OMA fields as a constant variable) after 6 hours of simulation and improves the estimation of trajectories up to 28% after 48 hours. The performance of the forecast is observed to be variable in space and time, related to the different ocean processes governing the local ocean circulation.
Understanding Heavy Lake-Effect Snowfall: The Vertical Structure of Radar Reflectivity in a Deep Snowband over and downwind of Lake Ontario
Authors: Welsh Dan , Geerts Bart , Jing Xiaoqin , Bergmaier Philip T. , Minder Justin R. , Steenburgh W. James , Campbell Leah S. 
Published: August 2016

AbstractThe distribution of radar-estimated precipitation from lake-effect snowbands over and downwind of Lake Ontario shows more snowfall in downwind areas than over the lake itself. Here, two nonexclusive processes contributing to this are examined: the collapse of convection that lofts hydrometeors over the lake and allows them to settle downwind; and stratiform ascent over land, due to the development of a stable boundary layer, frictional convergence, and terrain, leading to widespread precipitation there. The main data sources for this study are vertical profiles of radar reflectivity and hydrometeor vertical velocity in a well-defined, deep long-lake-axis-parallel band, observed on 11 December 2013 during the Ontario Winter Lake-effect Systems (OWLeS) project. The profiles are derived from an airborne W-band Doppler radar, as well as an array of four K-band radars, an X-band profiling radar, a scanning X-band radar, and a scanning S-band radar.The presence of convection offshore is evident from deep, strong (up to 10 m s−1) updrafts producing bounded weak-echo regions and locally heavily rimed snow particles. The decrease of the standard deviation, skewness, and peak values of Doppler vertical velocity during the downwind shore crossing is consistent with the convection collapse hypothesis. Consistent with the stratiform ascent hypothesis are (i) an increase in mean vertical velocity over land; and (ii) an increasing abundance of large snowflakes at low levels and over land, due to depositional growth and aggregation, evident from flight-level and surface particle size distribution data, and from differences in reflectivity values from S-, X-, K-, and W-band radars at nearly the same time and location.
A Dynamical Initialization Scheme for Binary Tropical Cyclones
Authors: Liu Hao-Yan , Tan Zhe-Min 
Published: August 2016

AbstractThis paper reports on a dynamical initialization scheme for binary vortices (BVDI) that was developed to improve the initial conditions supplied to the models used to forecast binary tropical cyclones (TCs). For binary TCs, one TC can be regarded as the environment for the other TC’s development. Based on the dynamical initialization scheme for a single vortex (SVDI), a specified multistep iteration of SVDI was introduced in the BVDI scheme to ensure that each TC develops under conditions of realistic binary vortices interaction during the 6-h cycle run. In the BVDI scheme, each TC is initialized twice within a continuously adjusted environmental flow. Four clusters of forecast simulations with different initial conditions were run for 11 pairs of binary TCs over the northwest Pacific. The forecasts of binary TCs by the BVDI scheme reduced the position and intensity errors associated with the forecast TCs by 35.2% and 56.6%, respectively, compared with those without initialization, and also performed better than the direct extension of the SVDI scheme to binary TCs. The representation of binary vortices interaction will need to be improved for initialization and future forecasts of binary TCs.
Palliative homecare is associated with reduced high- and low-acuity emergency department visits at the end of life: A population-based cohort study of cancer decedents
Authors: Sutradhar Rinku , Barbera Lisa , Seow Hsien-Yeang 
Published: August 2016

Background: Prior work shows that palliative homecare services reduce the subsequent need for hospitalizations and emergency services; however, no study has investigated whether this association is present for emergency department visits of high acuity or whether it only applies to low-acuity emergency department visits. Aim: To examine the association between palliative versus standard homecare nursing and the rate of high-acuity and low-acuity emergency department visits among cancer decedents during their last 6 months of life. Design: This is a retrospective cohort study of end-of-life homecare patients in Ontario, Canada, who had confirmed cancer cause of death from 2004 to 2009. A multivariable Poisson regression analysis was implemented to examine the association between the receipt of palliative homecare nursing (vs standard homecare nursing) and the rate of high- and low-acuity emergency department visits, separately. Results: There were 54,743 decedents who received homecare nursing in the last 6 months of life. The receipt of palliative homecare nursing decreased the rate of low-acuity emergency department visits (relative rate = 0.53, 95% confidence interval = 0.50–0.56) and was significantly associated with a larger decrease in the rate of high-acuity emergency department visits (relative rate = 0.37, 95% confidence interval = 0.35–0.38). Conclusion: Receiving homecare nursing with palliative intent may decrease the need for dying cancer patients to visit the emergency department, for both high and low-acuity visits, compared to receiving general homecare nursing. Policy implications include building support for additional training in palliative care to generalist homecare nurses and increasing access to palliative homecare nursing.
Feasibility of assessing patients’ acceptable pain in a randomized controlled trial on a patient pain education program
Authors: Oldenmenger Wendy H , van der Rijt Carin CD 
Published: August 2016

Background: For patients with cancer-related pain, the numeric rating scale is the most frequently used instrument to measure pain intensity. In the literature, it has been suggested to interpret patient-reported ratings of pain in relation to the pain intensity which is acceptable to the individual patient. Aim: We aimed to examine the feasibility and course of acceptable pain intensity. Design: A secondary analysis of a randomized controlled trial that tested the effectiveness of standard care versus standard care supplemented by a pain consultation combined with a patient pain education program. Setting: A total of 72 patients were included from an outpatient oncology clinic of a university hospital. They were diagnosed with cancer-related nociceptive pain with an average pain intensity ⩾4. Results: Most patients (97%) were able to give a score for acceptable pain. Almost half of the patients scored their acceptable pain in the range of moderate to severe. Patients’ ratings of acceptable pain were stable; after 8 weeks, 69% of patients had a variation of up to 1 point compared to baseline. However, the mean acceptable pain intensity remained equal in the standard care group (from 4.6 (range: 0–8) to 5.0 (range: 2–8)) and decreased in the intervention group (from 4.6 (range: 2–8) to 3.8 (range: 0–7, p < 0.01), difference between groups p < 0.05). Conclusion: Measurement of acceptable pain intensity is feasible. Patients with additional pain treatment became more critical and accepted less pain. More research is needed before we can use acceptable pain intensity as a reference for the interpretation of pain ratings.