bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of qualitative response models in a relevance study of older adults' health depreciation and medical care demand
Authors: Weng Shuo‐Chun , Chen Yu‐Chi , Chen Ching‐Yu , Cheng Yuan‐Yang , Tang Yih‐Jing , Yang Shu‐Hui , Lin Jwu‐Rong ,   on behalf of the CGG‐TCVGH investigators
Published: June 2016

AimThe effect of health depreciation in older people on medical care demand is not well understood. We tried to assess the medical care demand with length of hospitalization and their impact on profits as a result of health depreciation.MethodsAll participants who underwent comprehensive geriatric assessment were from a prospective cohort study at a tertiary hospital. A total of 1191 cases between September 2008 to October 2012 were investigated. Three sets of qualitative response models were constructed to estimate the impact of older adults' health depreciation on multidisciplinary geriatric care services. Furthermore, we analyzed the factors affecting the composite end‐point of rehospitalization within 14 days, re‐admission to the emergency department within 3 days and patient death.ResultsGreater health depreciation in elderly patients was positively correlated with greater medical care demand. Three major components were defined as health depreciation: elderly adaptation function, geriatric syndromes and multiple chronic diseases. On admission, the better the basic living functions, the shorter the length of hospitalization (coefficient = −0.35, P < 0.001 in Poisson regression; coefficient = −0.33, P < 0.001 in order choice profit model; coefficient = −0.29, P < 0.001 in binary choice profit model). The major determinants for poor outcome were male sex, middle old age and length of hospitalization. However, factors that correlated with relatively good outcome were functional improvement after medical care services and level of disease education.ConclusionsAn optimal allocation system for selection of cases into multidisciplinary geriatric care is required because of limited resources. Outcomes will improve with health promotion and preventive care services. Geriatr Gerontol Int 2017; 17: 645–652.
Immunohistochemical expression profiles of solute carrier transporters in alpha‐fetoprotein‐producing gastric cancer
Authors: Shimakata Takaaki , Kamoshida Shingo , Kawamura Jumpei , Ogane Naoki , Kameda Yoichi , Yanagita Emmy , Itoh Tomoo , Takeda Risa , Naka Ayano , Sakamaki Kuniko , Hayashi Yurie , Kuwao Sadahito 
Published: June 2016

AimsAlpha‐fetoprotein (AFP)‐producing gastric cancer (GC) is an aggressive tumour with high rates of liver metastasis and poor prognosis, and for which a validated chemotherapy regimen has not been established. Drug uptake by solute carrier (SLC) transporters is proposed as one of the mechanisms involved in sensitivity to chemotherapy. In this study, we aimed to develop important insights into effective chemotherapeutic regimens for AFP‐producing GC.Methods and resultsWe evaluated immunohistochemically the expression levels of a panel of SLC transporters in 20 AFP‐producing GCs and 130 conventional GCs. SLC transporters examined were human equilibrative nucleoside transporter 1 (hENT1), organic anion transporter 2 (OAT2), organic cation transporter (OCT) 2, OCT6 and organic anion‐transporting polypeptide 1B3 (OATP1B3). The rates of high expression levels of hENT1 (hENT1high) and OAT2 (OAT2high) were statistically higher in AFP‐producing GC, compared with conventional GC. When analysing hENT1 and OAT2 in combination, hENT1high/OAT2high was the most particular expression profile for AFP‐producing GC, with a greater significance than hENT1 or OAT2 alone. However, no significant differences in OCT2, OCT6 or OATP1B3 levels were detected between AFP‐producing and conventional GCs. However, immunoreactivity for hENT1, OAT2 and OCT6 tended to be increased in GC tissues compared with non‐neoplastic epithelia.ConclusionsBecause hENT1 and OAT2 are crucial for the uptake of gemcitabine and 5‐fluorouracil, respectively, our results suggest that patients with AFP‐producing GC could potentially benefit from gemcitabine/fluoropyrimidine combination chemotherapy. Increased expression of hENT1, OAT2 and OCT6 may also be associated with the progression of GC.
Effect of continuous ultrasonic irrigation on postoperative pain in mandibular molars with nonvital pulps: a randomized clinical trial
Authors: Middha M. , Sangwan P. , Tewari S. , Duhan J. 
Published: June 2016

AbstractAimTo evaluate via a randomized clinical trial the effect of continuous ultrasonic irrigation (CUI) on postoperative pain in mandibular molars with nonvital pulps.MethodologySeventy mandibular molars with nonvital pulps and apical periodontitis were treated endodontically using two different irrigation techniques. The patients were randomly allocated to one of two groups, CUI (n = 35) and syringe irrigation (SI) (n = 35). The CUI group received irrigant activation using a Proultra Piezoflow ultrasonic needle as the final irrigation protocol, whilst in the SI group, the final irrigation was performed using 27‐gauge needle. All the patients were prescribed ibuprofen 400 mg to be taken every 8 h, if required. Postoperative pain using a visual analog scale and analgesic intake were recorded everyday for 7 days. Data were analysed using chi–Square, Mann–Whitney and multiple linear regression tests.ResultsMean postoperative pain was lower in the CUI as compared to SI group, but the difference was significant on the first day only (P = 0.032). The overall 24‐h pain prevalence was 41.4%. CUI had a lower incidence of pain (31.4%) as compared to the SI group (51.4%), but the difference was not significant (P > 0.05). No significant difference was observed in analgesic consumption between the groups (P > 0.05). Regression analysis revealed a significant association of mean postoperative pain at 24 h with the irrigant protocol (P = 0.017) and preoperative pain (P = 0.000).ConclusionA significant difference was observed between CUI and syringe irrigation on the first postoperative day following chemo‐mechanical preparation. However, the benefit observed was not clinically relevant.
A newly designed observation and response chart's effect upon adverse inpatient outcomes and rapid response team activity
Authors: O'Connell A. , Flabouris A. , Kim S. W. , Horwood C. , Hakendorf P. , Thompson C. H. 
Published: June 2016

BackgroundAdverse inpatient events may diminish with earlier response to clinical deterioration. Observation and response charts with a tiered escalation response are recommended for use.AimsTo examine the impact of an observation and response chart and altered calling criteria on rapid response team (RRT) calls, cardiac arrests and intensive care unit (ICU) admissions from the ward and hospital deaths.MethodsLinked administrative and clinical data from an Australian, adult tertiary hospital for August 2007 to June 2013 (pre‐chart) and July 2013 to December 2014 (post‐chart) and analysed using interrupted time series analysis.ResultsPre‐chart RRT calls were increasing by 1.7 calls per 10 000 hospital admissions per month, whilst ICU admissions from the ward, deaths and cardiac arrests were decreasing by 0.3, 0.25 and 0.079 per 10 000 admissions per month respectively.Immediately upon chart introduction, the RRT call rate increased by 82% (66–98% CI; P < 0.01), the ward admissions to ICU rate increased by 41% (14–67% CI; P < 0.01) and the rates of deaths and cardiac arrests did not change.In the post chart period, both the pre‐chart increasing trend in the rate of RRT and decreasing trend in the rate of ICU admissions changed significantly to become constant. The pre chart trends in the cardiac arrest rate and hospital mortality did not change.ConclusionObservation and response charts increased RRT and ICU workload without improving cardiac arrest rate or mortality. Future chart evaluation should identify features beneficial to patient outcomes and refine those that consume critical care resources that are not associated with improved patient outcomes.
Variation of within‐crop microhabitat use by Drosophila suzukii (Diptera: Drosophilidae) in blackberry
Authors: Diepenbrock L. M. , Burrack H. J. 
Published: June 2016

AbstractDrosophila suzukii Matsumara (Diptera: Drosophilidae) is an invasive vinegar fly that infests ripe and ripening soft skinned fruits. In the south‐eastern United States, blackberry (Rubus spp.) crops are heavily impacted by D. suzukii, and current management tactics rely on the use of broad‐spectrum insecticides targeted to adult populations. An improved understanding of D. suzukii biology and ecology are necessary to create sustainable management options. Knowledge of how D. suzukii interacts with resources will enable targeted management actions in the future. In this present study, we monitored larval infestation throughout the blackberry canopy and found that infestation was highest in the inner portion of the canopy and lower in more exposed locations. We also documented higher humidity within the cane canopy relative to the edge of the field. A difference in abiotic conditions may create within‐crop microhabitats that D. suzukii is able to exploit. Future research will explore how to take advantage of these microhabitats in pest management programs.
Decolonizing Research Methods for Family Science: Creating Space at the Center
Authors: Bermúdez J. Maria , Muruthi Bertranna A. , Jordan Lorien S. 
Published: June 2016

AbstractNorth America has a strong legacy of colonization, and a decolonizing agenda has important implications for the field of family science. Decolonizing epistemologies and research methods have gained momentum in the biological and social sciences. These research methods challenge the status quo and the superiority of Western ideologies and focus on agendas meant to honor marginalized people and their local knowledge and experiences. Decolonizing ideologies and practices offer an opportunity for researchers to decenter the existing power structure of neocolonial paradigms and knowledge production while simultaneously acknowledging the needs of multiple stakeholders in research. Our goal is to review the various forms of colonialisms, offer methodological considerations for family research, highlight the advantages and challenges of using a decolonizing approach, and offer reflexive questions to situate the researcher focused on a decolonizing research agenda for family science.
“It Has to be Perfect!”: The Development of Perfectionism and the Family System
Authors: Rasmussen Katie E. , Troilo Jessica 
Published: June 2016

AbstractPerfectionism has deleterious effects on developmental outcomes for children, youth, and adults. Despite this, there is controversy regarding the nature of perfectionism itself and whether it can be positive or negative. This article identifies key findings in the perfectionism literature, reviews current research literature on the conceptualizations and antecedents of perfectionism, and outlines concepts of family systems theory that help explain how perfectionism develops in families. Three models are proposed to explain the development of maladaptive perfectionism, socially prescribed and self‐oriented perfectionism, and other‐oriented perfectionism—all in the context of the family system. Implications for future theory development, research, and practices are discussed, emphasizing the role of resilient processes within and outside the family unit.
Edge‐to‐Edge Technique to Minimize Ovelapping of Multiple Bioresorbable Scaffolds Plus Drug Eluting Stents in Revascularization of Long Diffuse Left Anterior Descending Coronary Artery Disease
Authors: Rigatelli Gianluca , Avvocata Fabio Dell’ , Ronco Federico , Giordan Massimo , Roncon Loris , Caprioglio Francesco , Grassi Giuseppe , Faggian Giuseppe , Cardaioli Paolo 
Published: June 2016

BackgroundImplantation of Drug Eluting Stents (DES) plus bioresorbable scaffolds (BVS) in very long diffuse left anterior descending coronary artery (LAD) disease may be problematic because of multiple devices overlapping. We sought to assess the short and mid‐tern outcomes of combined implantation of DES and BVS using a novel “edge‐to‐edge” technique in patients with diffuse LAD disease.MethodsPatients with long diffuse LAD disease were enrolled in a prospective registry from 1st August 2014 to 1st August 2015 and treated with IVUS‐aided percutaneous coronary intervention using a DES plus a single or multiple BVS using a novel “edge‐to‐edge” technique. Clinical follow up and invasive follow up driven by clinical justification was performed.ResultsTwenty‐three patients (5 females, mean age 59.1± 9.1 years) were enrolled. Mean length of LAD disease was 73.1 ± 20.6 mm. Mean number of DES and BVS implanted was 1.2 ± 0.4 and 1.7 ± 1.3, respectively. At a mean follow‐up of 11.3 ± 3.8 months, no stent thrombosis or MACE were observed. Angiographic and IVUS follow‐up at a mean of 6.6 ± 0.7 months showed no significant angiographic restenosis and no appreciable stent gaps.ConclusionsIn revascularization of long diffuse disease of the LAD, the edge‐to‐edge implantation technique appears to be feasible resulting in no restenosis or thrombosis on the short‐term follow‐up. (J Interven Cardiol 2016;29:275–284)
Comparison of 4.5‐Year Outcomes of Bare‐Metal and Zotarolimus‐Eluting Stents in New York
Authors: Qian Feng , Zhong Ye , Kheocha‐On Pornchanok , Hannan Edward L. 
Published: June 2016

BackgroundBoth bare‐metal stents (BMS; the first‐generation coronary stent) and zotarolimus‐eluting stents (ZES; a second‐generation drug‐eluting stent [DES]) have been widely utilized to treat coronary heart disease. However, the long‐term comparative effectiveness of BMS and ZES remains unclear. The purpose of this study was to evaluate long‐term comparative effectiveness of BMS versus ZES.MethodsWe created a longitudinal database by linking the New York State (NYS) cardiac registries, statewide hospital discharge data, the National Death Index (NDI), and the U.S. Census file (2010) for patients receiving either BMS or ZES during the 2008–2009 period. We examined the rates of all‐cause mortality, acute myocardial infarction (AMI), target‐lesion PCI (TLPCI), and target‐vessel coronary artery bypass graft (TVCABG) surgery for a follow‐up period of 4.5 years. A total of 10,443 propensity score matched pairs were compared using the Kaplan–Meier method and Cox proportional hazards regression adjusting for patient risk factors.ResultsWe found that patients receiving ZES had a lower rate of 4.5‐year mortality (adjusted hazard ratio AHR: 0.68, 95% confidence interval CI: 0.63–0.73), AMI (AHR: 0.89, 95% CI: 0.80–0.98), and TVCABG (AHR: 0.84, 95% CI: 0.71–0.99) but a similar rate of TLPCI (AHR: 1.02, 95% CI: 0.93–1.12). For “off‐label” and “high‐risk” subgroups, ZES was associated with improved mortality and generally better or non‐inferior AMI, TLPCI, and TVCABG outcomes relative to BMS.ConclusionsCompared with BMS, ZES was associated with lower long‐term mortality, AMI and TVCABG. (J Interven Cardiol 2016;29:265–274)
Project ReFresh: Testing the Efficacy of a School‐Based Classroom and Cafeteria Intervention in Elementary School Children
Authors: Song Hee‐Jung , Grutzmacher Stephanie , Munger Ash L. 
Published: June 2016

ABSTRACTBACKGROUNDThe purpose of this study was to assess the effect of a school‐based nutrition program using a cafeteria environment intervention and classroom nutrition education on self‐reported fruit and vegetable (FV) consumption, self‐efficacy to select FV, and preference for healthy foods.METHODSUsing quasi‐experimental pre‐post design with 3 study conditions, a total of 665 fourth‐ and fifth‐grade students participated in the study. The comprehensive intervention included a behavioral economics cafeteria intervention and weekly classroom nutrition education for 1 academic year. The intervention was designed and delivered by the extension system.RESULTSThe comprehensive group showed significant improvement in some indicators including eating vegetables for lunch (p = .007), number of days eating vegetables (p < .001) and fruits (p < .001) in the last week, and self‐efficacy in preparing FV at home (p = .034) compared to the control and cafeteria groups. Food preference of some food items, including oatmeal (p = .036 for cafeteria group, p < .001 for comprehensive group), whole grain noodles (p = .011 for comprehensive group), and vegetables (p = .003 for comprehensive group), significantly improved in the cafeteria and/or comprehensive group.CONCLUSIONSClassroom nutrition education combined with cafeteria improvement has the potential to improve diet‐related behavior of elementary school children. Also, collaborative partnership between schools and extension can enhance program sustainability.
Adoption of Preventive Measures and Attitudes Toward the H1N1 Influenza Pandemic in Schools
Authors: Pérez Anna , Rodríguez Tània , López Maria José , Continente Xavier , Nebot Manel 
Published: June 2016

ABSTRACTBACKGROUNDThis study describes the perceived impact of H1N1 influenza and the adoption of the recommended measures to address the pandemic in schools.METHODSA cross‐sectional self‐reported survey was conducted in 433 schools in Barcelona addressed to the school principal or the H1N1 influenza designated person. A descriptive analysis was performed, stratifying by educational level and type of school. A logistic regression analysis also was conducted.RESULTSAround 70% of the respondents reported that there had been H1N1 influenza cases among students, being this percentage significantly higher among those schools offering primary education (74.4%) (p < .05). The main measures (single‐use paper towels, availability of sanitizer solutions and 15 minutes ventilation per day of enclosed spaces) were implemented in most of the centers. However, the correct adoption of the main measures took place in around 30% of the schools, being the percentage lower in those offering only secondary education (Odds ratio [OR]: 0.518; 95% confidence interval [CI]:0.272‐0.986) and those located in medium (OR: 0.438, 95% CI: 0.234‐0.811) or low socioeconomic status (SES) districts (OR: 0.321, 95% CI: 0.159‐0.649).CONCLUSIONSDespite the climate of social alarm, the perceived impact of H1N1 influenza in most schools was moderate. In future potential threats, the educational level and the SES of the school should be considered, especially when measures requiring purchasing any product are recommended but not provided.
Promoting Fitness and Safety in Elementary Students: A Randomized Control Study of the Michigan Model for Health
Authors: O'Neill James M. , Clark Jeffrey K. , Jones James A. 
Published: June 2016

ABSTRACTBACKGROUNDIn elementary grades, comprehensive health education curricula have demonstrated effectiveness in addressing singular health issues. The Michigan Model for Health (MMH) was implemented and evaluated to determine its impact on nutrition, physical fitness, and safety knowledge and skills.METHODSSchools (N = 52) were randomly assigned to intervention and control conditions. Participants received MMH with 24 lessons in grade 4 and 28 more lessons in grade 5 including material focusing on nutrition, physical fitness, and safety attitudes and skills. The 40‐minute lessons were taught by the classroom teacher who received curriculum training and provided feedback on implementation fidelity. Self‐report survey data were collected from the fourth‐grade students (N = 1983) prior to the intervention, immediately after the intervention, and 6 weeks after the intervention, with the same data collection schedule repeated in fifth grade. Analysis of the scales was conducted using a mixed‐model approach.RESULTSStudents who received the curriculum had better nutrition, physical activity, and safety skills than the control‐group students. Intervention students also reported higher consumption of fruits; however, no difference was reported for other types of food consumption.CONCLUSIONThe effectiveness of the MMH in promoting fitness and safety supports the call for integrated strategies that begin in elementary grades, target multiple risk behaviors, and result in practical and financial benefits to schools.
Phylogeny of the Rosidae: A dense taxon sampling analysis
Authors: Sun Miao , Naeem Rehan , Su Jun‐Xia , Cao Zhi‐Yong , Burleigh J. Gordon , Soltis Pamela S. , Soltis Douglas E. , Chen Zhi‐Duan 
Published: June 2016

AbstractRosidae, a clade of approximately 90 000 species of angiosperms, exhibits remarkable morphological diversity and extraordinary heterogeneity in habitats and life forms. Resolving phylogenetic relationships within Rosidae has been difficult, in large part due to nested radiations and the enormous size of the clade. Current estimates of phylogeny contain areas of poor resolution and/or support, and there have been few attempts to synthesize the available data into a comprehensive view of Rosidae phylogeny. We aim to improve understanding of the phylogeny of Rosidae with a dense sampling scheme using both newly generated sequences and data from GenBank of the chloroplast rbcL, atpB, and matK genes and the mitochondrial matR gene. We combined sequences from 9300 species, representing 2775 genera, 138 families, and 17 orders into a supermatrix. Although 59.26% of the cells in the supermatrix have no data, our results generally agree with previous estimates of Rosidae phylogeny and provide greater resolution and support in several areas of the topology. Several noteworthy phylogenetic relationships are recovered, including some novel relationships. Two families (Euphorbiaceae and Salvadoraceae) and 467 genera are recovered as non‐monophyletic in our sampling, suggesting the need for future systematic studies of these groups. Our study shows the value of a botanically informed bioinformatics approach and dense taxonomic sampling for resolving rosid relationships. The resulting tree provides a starting point for large‐scale analyses of the evolutionary patterns within Rosidae.
The role of floating mucilage in the invasive spread of the benthic microalga Chrysophaeum taylorii
Authors: Caronni Sarah , Delaria Maria Anna , Heimann Kirsten , Macri Giovanni , Navone Augusto , Panzalis Pieraugusto , Ceccherelli Giulia 
Published: June 2016

AbstractChrysophaeum taylorii Lewis & Bryan (Pelagophyceae) is a mucilage‐producing benthic microalga that has recently begun to spread in the Mediterranean Sea, where a range expansion is occurring. This paper presents the results of three field experiments that aimed to increase the knowledge on mucilage provision mechanisms for this benthic microalga and to evaluate the importance of mucilage in its range expansion. By means of two correlative field experiments (several years of data were considered to encompass the variability of mucilage cover) we found that, on the sea bottom, mucilage cover does not depend on epilithic cell density and that both its cover and settling are affected by water flow. We also tested the hypothesis that cells embedded in floating mucilage fall on the underlying substratum, where their abundance depends on water flow. To this aim, in the field we manipulated the presence of floating mucilaginous aggregates in cages with different levels of exposure to winds. The abundance of C. taylorii cells on the substratum under cages with mucilage was compared with that of two control treatments: cages without mucilage and mucilage in still water, in the field and lab, respectively. The results suggested that mucilage can represent an excellent strategy for the species to disperse, as C. taylorii cells fall from the floating mucilage and, if the water flow is unimportant, settle on hard substrata just underneath the cage. This study enriches the portfolio of knowledge of the dispersal strategies of microalgae and contributes to the understanding of the spread of invasive species.