bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds
Authors: Bernard Angela , Lacroix Céline , Cabiddu Maria G , Neyts Johan , Leyssen Pieter , Pompei Raffaello 
Published: December 2015

Background The Enterovirus genus of the Picornaviridae is represented by several viral pathogens that are associated with human disease, namely Poliovirus 1, Enterovirus 71 and Rhinoviruses. Enterovirus 71 has been associated with encephalitis, while Rhinoviruses are a major cause of asthma exacerbations and chronic obstructive pulmonary disease. Based on the structure of both pleconaril and pirodavir, we previously synthesized some original compounds as potential inhibitors of Rhinovirus replication. Methods These compounds were explored for in vitro antiviral potential on other human pathogenic Enteroviruses, namely Enterovirus 71 on rhabdo-myosarcoma cells, Coxsackievirus B3 on Vero cells, Poliovirus 1 and Echovirus 11 on BGM cells. Results Activity was confirmed for compound against Rhinovirus 14. Furthermore, few compounds showed a cell-protective effect on Enterovirus 71, presented a marked improvement as compared to the reference drug pleconaril for inhibitory activity on both Enterovirus 71 and Poliovirus 1. The most striking observation was the clear cell protective effect for the set of analogues in a virus-cell-based assay for Echovirus 11 with an effective concentration (EC50) as low as 0.3 µM (Selectivity index or SI = 483), and selectivity indexes greater than 857 (EC50 = 0.6 µM) and 1524 (EC50 = 0.33 µM). Conclusion Some of the evaluated compounds showed potent and selective antiviral activity against several enterovirus species, such as Enterovirus 71 (EV-A), Echovirus 11 (EV-B), and Poliovirus 1 (EV-C). This could be used as a starting point for the development of other pleconaril/pirodavir-like enterovirus inhibitors with broad-spectrum activity and improved effects as compared to the reference drugs.
Perceptions of barriers, facilitators and motivators related to use of prenatal care: A qualitative descriptive study of inner-city women in Winnipeg, Canada
Authors: Heaman Maureen I , Sword Wendy , Elliott Lawrence , Moffatt Michael , Helewa Michael E , Morris Heather , Tjaden Lynda , Gregory Patricia , Cook Catherine 
Published: December 2015

Objective: The objective of this qualitative descriptive study was to explore the perceptions of women living in inner-city Winnipeg, Canada, about barriers, facilitators, and motivators related to their use of prenatal care. Methods: Individual, semi-structured interviews were conducted in person with 26 pregnant or postpartum women living in inner-city neighborhoods with high rates of inadequate prenatal care. Interviews averaged 67 min in length. Recruitment of participants continued until data saturation was achieved. Inductive content analysis was used to identify themes and subthemes under four broad topics of interest (barriers, facilitators, motivators, and suggestions). Sword’s socio-ecological model of health services use provided the theoretical framework for the research. This model conceptualizes service use as a product of two interacting systems: the personal and situational attributes of potential users and the characteristics of health services. Results: Half of the women in our sample were single and half self-identified as Aboriginal. Participants discussed several personal and system-related barriers affecting use of prenatal care, such as problems with transportation and child care, lack of prenatal care providers, and inaccessible services. Facilitating factors included transportation assistance, convenient location of services, positive care provider qualities, and tangible rewards. Women were motivated to attend prenatal care to gain knowledge and skills and to have a healthy baby. Conclusion: Consistent with the theoretical framework, women’s utilization of prenatal care was a product of two interacting systems, with several barriers related to personal and situational factors affecting women’s lives, while other barriers were related to problems with service delivery and the broader healthcare system. Overcoming barriers to prenatal care and capitalizing on factors that motivate women to seek prenatal care despite difficult living circumstances may help improve use of prenatal care by inner-city women.
Converging approaches to understanding early onset familial Alzheimer disease: A First Nation study
Authors: Cabrera Laura Y , Beattie B Lynn , Dwosh Emily , Illes Judy 
Published: December 2015

Objectives: In 2007, a novel pathogenic genetic mutation associated with early onset familial Alzheimer disease was identified in a large First Nation family living in communities across British Columbia, Canada. Building on a community-based participatory study with members of the Nation, we sought to explore the impact and interplay of medicalization with the Nation’s knowledge and approaches to wellness in relation to early onset familial Alzheimer disease. Methods: We performed a secondary content analysis of focus group discussions and interviews with 48 members of the Nation between 2012 and 2013. The analysis focused specifically on geneticization, medicalization, and traditional knowledge of early onset familial Alzheimer disease, as these themes were prominent in the primary analysis. Results: We found that while biomedical explanations of disease permeate the knowledge and understanding of early onset familial Alzheimer disease, traditional concepts about wellness are upheld simultaneously. Conclusion: The analysis brings the theoretical framework of “two-eyed seeing” to the case of early onset familial Alzheimer disease for which the contributions of different ways of knowing are embraced, and in which traditional and western ways complement each other on the path of maintaining wellness in the face of progressive neurologic disease.
Aortic valve reconstruction using pericardium for infective endocarditis
Authors: Takahashi Shinya , Katayama Keijiro , Uchida Naomichi , Sueda Taijiro 
Published: December 2015

Background: Aortic valve endocarditis with annular abscess is a serious disorder, requiring complete debridement of infected tissue and aortic valve repair. Methods: 68-year-old male presented with infective endocarditis of severe aortic regurgitation with mobile vegetations on the aortic valve and Valsalva sinus aneurysm. Results: He underwent emergency surgery that included complete patch and aortic valve reconstruction using autologous pericardium. Antibiotics was strongly administrated. Echocardiography showed trivial aortic regurgitation and computed tomography showed reconstructed aortic valve. Conclusion: This unique technique of aortic valve reconstruction was successfully applied to a patient with aortic valve endocarditis.
Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations
Authors: Ljungström Viktor , Cortese Diego , Young Emma , Pandzic Tatjana , Mansouri Larry , Plevova Karla , Ntoufa Stavroula , Baliakas Panagiotis , Clifford Ruth , Sutton Lesley-Ann , Blakemore Stuart J. , Stavroyianni Niki , Agathangelidis Andreas , Rossi Davide , Höglund Martin , Kotaskova Jana , Juliusson Gunnar , Belessi Chrysoula , Chiorazzi Nicholas , Panagiotidis Panagiotis , Langerak Anton W. , Smedby Karin E. , Oscier David , Gaidano Gianluca , Schuh Anna , Davi Frederic , Pott Christiane , Strefford Jonathan C. , Trentin Livio , Pospisilova Sarka , Ghia Paolo , Stamatopoulos Kostas , Sjöblom Tobias , Rosenquist Richard 
Published: December 2015

Key Points
Whole-exome sequencing of CLL patients who relapsed after FCR treatment revealed frequent mutations in RPS15. RPS15 mutations are likely to be early clonal events and confer poor prognosis.
Creating the Conditions for Disclosure of Internal Capacity of the Individual Estate Agent Through the Development of Personnel in the Organization
Authors: Леднева  , Ledneva S. , Чумакова  , Chumakova S. 
Published: December 2015

The article reveals the problem of creation of a company providing services
in the field of real estate development of an effective system of personnel
focused on the disclosure of internal capacity of the individual employee. This
concept is treated as a set of qualities that underlie their professional, social
and psychological competence. The authors offer a practice-oriented model
of development staff allows to update the internal capacity of the individual
realtors and use it effectively in the implementation of real estate transactions.
Potret Representasi Pedagogical Content Knowledge (PCK) Guru dalam Mengajarkan Materi Getaran dan Gelombang pada Siswa Smp
Authors: Purwaningsih Endang 
Published: December 2015

<span>Learning materials of vibrations and waves in physics involve abstract mathematical knowledge, not easy to be understood, and frequently generate misconceptions. However, the subject is fundamental prerequisite for mastering more complicated physical concepts. On the other hand, teachers´ materials comprehension itself can affect the way teachers teaching and giving learning experience to the students. Here, we use descriptive research to figure out teacher´s pedagogical content knowledge (PCK) representation during teaching and learning process of vibrations and waves for junior high school grade VIII. Four professional junior high school teachers were chosen as sample. The PCK representation was focused on the content representation (CoRe) which represents teachers´ materials comprehension and their special aspects. Data collections have been done by means documentation study, ongoing classroom activities observation and interviews with the teachers as well as the students. Outcome of this research are: 1) Basic ideas/concepts expected by teachers for students to learn are not yet covering the basic concept needed to understand the concept itself, 2) Teachers are not yet mastering the teaching materials comprehensively, 3) Classroom activities/learning experiences and the method given to the students are not varied.</span>
Uji Kemurnian DNA Melon (Cucumis melo L.) Kultivar “Gama Melon Basket” Menggunakan Surface Plasmon Resonance (SPR) Berbasis Nanopartikel Perak
Authors: T Thoyibi , Arifin Muhammad , Abraha Kamsul 
Published: December 2015

DNA level of purity has been tested by observing the phenomenon of surface plasmon resonance (SPR) in silver film + silver (Ag) nanoparticles system as DNA sensor using Kretschmann configuration. Surface plasmon resonance (SPR) phenomenon observed in the resonance condition of reflectance spectrum vary with incident angle of laser, beamed toward prism. System is built as a model for DNA purity test instrument that give higher accuracy. DNA purity testing was conducted by placing DNA layer with various ratio on prism in order to get the angle shift value in each sample as a result. Purity level of DNA indicates the DNA quality based on the ratio between the amount of pure DNA compared to the amount of impurity materials (protein). After the deposition of DNA in ratio 1,774, 1,838 and 1,916 SPR angle shifted , and respectively. Characteristic differences of DNA with different purity (ratio) are shown by reflectance value that is getting higher at a smaller ratio, indicates that in the higher DNA ratio the angle shift is getting smaller. SPR angle shift which is occurred before and after DNA deposition shows the sensitivity of SPR as DNA sensor.
Weber’s electrodynamics for the hydrogen atom
Authors: Torres-Silva H. , López-Bonilla J. , López-Vázquez R. , Rivera-Rebolledo J. 
Published: December 2015

<p>The original Weber action at a distance theory is valid for slowly varying effects, and it in addition to predicting all of the usual electrodynamical results, leads to crucial effects where the Maxwell theory fails. The Weber’s approach is an alternative to <a title="Maxwell's Equations" href="http://en.wikipedia.org/wiki/Maxwell%27s_Equations">Maxwell electrodynamics</a>, where the <a title="Coulomb's Law" href="http://en.wikipedia.org/wiki/Coulomb%27s_Law">Coulomb's law</a> becomes velocity dependent [1-6]. Here we prove that the Weber’s theory gives the fine structure energy level splitting for the hydrogen atom without the assumption of mass change with velocity.</p>
Factors Which Motivate Music Teachers’ Training in Their Working Environment
Authors: Bukantaitė Daiva , Kubiliūtė Monika 
Published: December 2015

Abstract
Aim of the study was to identify the factors that motivate teachers‘ learning in their work environment Participatory photography method is the kind of method where the participants of the research reply to the questions of the researcher by taking photographs. Later, the photographs are defined, explained and analyzed, while sharing the insights with the researcher. Every participant of the research was contacted prior to the research by telephone or e-mail. They were asked to take photographs of the factors that motivate them to study in their workplace; the time of the interview was arranged also. Some participants of the research invited the researchers to their schools because they wanted to take the pictures right before the interview. Others came to the interview with pictures they have already taken. 10 music teachers, who work at their institution for not less than three years, were chosen for the research. After the teachers submitted their photographs, they were asked a few main questions: Why did you take a photograph of this particular phenomenon? Why does it motivate you to learn in your work environment? How do you learn? Why do you learn in your workplace? Every research participant was personally introduced to the goal of the research and got their questions answered. Participation was voluntary. To endure the confidentiality of the participants, they were not asked to provide any personal or other kind of information that would help to identify them. The research was limited by the fact that the teachers represented different institutions and worked with students of different age, that is why only common tendencies were distinguished, no comparison or evaluation was performed. Findings: three groups of factors that encourage learning in a workplace were identified: evaluation (taking part in projects, competitions, received awards); functional (information technology use, workplace, tools (course books, traditional and untraditional instruments); structural (colleagues, students, going to concerts, trips, taking part in master classes). Conclusion: Teachers do not link "workplace", only with their work in class. Going to concerts, taking part in seminars, projects, student preparation for competitions, trips were also mentioned as learning factors. Teachers' learning in their workplace is encouraged by their desire to improve in their professional work, confidence in themselves and their opportunities, desire to feel good in their work environment.
Neutrophil-Gelatinase Associated Lipocalin (N-GAL) to Assess Perioperative Acute Kidney Injury in Hand-Assisted Laparoscopic Donor Nephrectomy: A Pilot Study
Authors: Aitken Emma , Vesey Alex , Glen Julie , Steven Mark , Clancy Marc 
Published: December 2015

Abstract
Perioperative insults, including hypotension, hypovolaemia and pneumoperitoneum may occur during laparoscopic live donor nephrectomy. These may have deleterious effects to both donor and recipient. The extent and significance of these insults is poorly understood and difficult to quantify. The aim of this study was to evaluate acute kidney injury (AKI) in the donor using the novel biomarker neutrophil-gelatinase associated lipocalin (N-GAL). We report the results of a pilot study of 20 patients undergoing hand-assisted live donor nephrectomy. eGFR and serum NGAL measurements (Triage CardioRenal Panel, Alere) were obtained preoperatively, immediately post-operatively, day 1 and 6 weeks post-operatively. Mean pre-operative eGFR was 105.6+/-10.1ml/min/1.73m2. Mean eGFR 6 weeks postoperatively demonstrated a 29.4+/-8.8% reduction from baseline. Serum N-GAL increased by 34.1+/-16.7% following an overnight fast pre-operatively (day 0) (ΔNGAL 45.1+/-36.0ng/ml), by a further 14.9+/-7.2% following surgery (immediate post-op). The largest ΔNGAL was observed during the pre-operative fasting period. ΔNGAL [day -1 to day 0] and [day -1 to post-op] were found to correlate inversely with eGFR at 6 weeks (p<0.05, r2=0.47 and p<0.001, r2=0.52 respectively). We conclude that clinically significant AKI does occur in the donor following live donor nephrectomy. Optimisation of perioperative fluid management is likely to have a protective role.
Progestogens in the prevention of miscarriage
Authors: Carp Howard J.A. 
Published: December 2015

Abstract
Progestational agents are often prescribed to prevent threatened miscarriage progressing to miscarriage, and subsequent miscarriages in recurrent pregnancy loss. Progestogens affect implantation, cytokine balance, natural killer cell activity, arachidonic acid release and myometrial contractility. A recent Cochrane review reported that progestogens were effective for treating threatened miscarriage with no harmful effects on mother or fetus. The results were not statistically different when vaginal progesterone was compared to placebo, (RR=0.47, 95% CI 0.17–1.30), whereas oral progestogen (dydrogesterone) was effective (RR=0.54, CI 0.35–0.84). The review concluded, that the small number of eligible studies, and the small number of the participants, limited the power of the metaanalysis. A later metaanalysis of five randomised controlled trials of threatened miscarriage comprised 660 patients. The results of 335 women who received dydrogesterone were compared to 325 women receiveing either placebo or bed rest. There was a 47% reduction in the odds ratio for miscarriage, (OR=0.47, CI 0.31–0.7). There was a 13% (44/335) miscarriage rate after dydrogesterone administration compared to 24% in control women. Recurrent miscarriage affects approximately 1% of women of child bearing age. A metaanalysis of progestational agents shows a 26% increase in the live birth rate. Again, dydrogesterone was associated with a more significant increase in the live birth rate than the other progestogens included in the metaanalysis.
Improving the Care of People with Long-Term Conditions in Primary Care: Protocol for the Enhance Pilot Trial
Authors: Healey Emma L. , Jinks Clare , Tan Valerie A. , Chew-Graham Carolyn A. , Lawton Sarah A. , Nicholls Elaine , Finney Andrew G. , Porcheret Mark , Cooper Vince , Lewis Martyn , Dziedzic Krysia S. , Wathall Simon , Mallen Christian D. 
Published: December 2015

Background Long-term conditions (LTCs) are important determinants of quality of life and healthcare expenditure worldwide. Whilst multimorbidity is increasingly the norm in primary care, clinical guidelines and the delivery of care remain focused on single diseases, resulting in poorer clinical outcomes. Osteoarthritis, and anxiety and/or depression frequently co-occur with other LTCs, yet are seldom prioritized by the patient or clinician, resulting in higher levels of disability, poorer prognosis, and increased healthcare costs. Objective To examine the feasibility and acceptability of an integrated approach to LTC management, tackling the under-diagnosis and under-management of osteoarthritis-related pain and anxiety and/or depression in older adults with other LTCs in primary care. Design The ENHANCE study is a pilot stepped-wedge cluster randomized controlled trial to test the feasibility and acceptability of a nurse-led ENAHNCE LTC review consultation for identifying, assessing, and managing joint pain, and anxiety and/or depression in patients attending LTC reviews. Specific objectives (process evaluation and research outcomes) will be achieved through a theoretically informed mixed-methods approach using participant self-reported questionnaires, a medical record review, an ENHANCE EMIS template, qualitative interviews, and audio recordings of the ENHANCE LTC review. Discussion Success of the pilot trial will be measured against the level of the primary care team engagement, assessment of training delivery, and degree of patient recruitment and retention. Patient satisfaction and treatment fidelity will also be explored. ISRCTN registry number: 12154418.
Notas acerca de la distribución de papilionidae (LEPIDOPTERA: PAPILIONOIDEA) en el norte de la Orinoquia colombiana
Authors: Agudelo M. Juan Carlos , Pérez Buitrago Néstor 
Published: December 2015

Se revisaron 56 ejemplares de mariposas de la familia Papilionidae colectados esporádicamente en el norte de la Orinoquia colombiana en municipios pertenecientes a los departamentos de Arauca, Norte de Santander y Casanare, en un rango altitudinal entre los 120 y 494 msnm. Los especímenes corresponden a tres géneros, siete especies y siete subespecies siendo las más abundantes Battus polydamas polydamas y Parides eurimedes arriphus con 15 y 12 individuos, respectivamente. Las siete especies identificadas corresponden al 11,5% de las 61 reportadas para Colombia y al 29,2% de las 24 especies de Papilionidae registradas para toda la región Orinoquia. A nivel regional la riqueza de Papilioniade en Arauca es igual a la reportada en una localidad en el Meta (siete sp.) y menor que la del departamento de Casanare (nueve sp.). Reportamos la ampliación de la distribución geográfica de cuatro subespecies a nivel regional.
Third Sector Commentary: 'Change in the Third Sector'
Authors: Turner James 
Published: December 2015

<p><strong><em>“All changed, changed utterly: A terrible beauty is born”</em></strong></p><p>Of all the quotes on the subject of change, it’s arguably W.B.Yeats’ refrain that is best known. And for the Third Sector over the past five years, the line is certainly apt. For many charities and voluntary organisations, funding cut-backs, redundancies and closures have often, indeed, been terrible. But there has also been beauty in the way that these groups have adapted and shifted to the changed environment.</p><p>It was this mixture of changed circumstances and flexible responses that the NETSRG wished to discuss at its July 2014 meeting. </p>
Cutting Edge: Ezrin Regulates Inflammation by Limiting B Cell IL-10 Production
Authors: Pore Debasis , Matsui Ken , Parameswaran Neetha , Gupta Neetu 
Published: December 2015

Abstract
IL-10 produced by B cells is important for controlling inflammation, thus underscoring the need to identify mechanisms regulating its production. In this study, we demonstrate that conditional deletion of ezrin in B cells increases IL-10 production induced by TLR4 ligation. The MyD88-independent Toll/IL-1R domain–containing adapter inducing IFN-β–IFN regulatory factor 3 pathway is required for Ezrin-deficient B cells to produce higher IL-10 upon LPS stimulation. Treatment of B cells with a novel small-molecule inhibitor of ezrin induces its dephosphorylation and increases LPS-induced NF-κB and IFN regulatory factor 3 activation and IL-10 secretion, indicating a role for threonine 567 phosphorylation of ezrin in limiting IL-10. Loss of ezrin in B cells results in dampened proinflammatory response to a sublethal dose of LPS in vivo, which is dependent on increased IL-10 production. Taken together, our data yield new insights into molecular and membrane-cytoskeletal regulation of B cell IL-10 production and reveal ezrin as a potential therapeutic target in inflammatory diseases.