bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delays in diagnosis are associated with poorer outcomes in adult hip dysplasia
Authors: Kennedy John W , Brydone Alistair S , Meek Dominic RM , Patil Sanjeev R 
Published: August 2017

Background and Aims Developmental dysplasia of the hip is a common cause of osteoarthritis. Periacetabular osteotomy can restore femoral head coverage; however, it is reserved for patients with minimal articular degeneration. We examined the relationship between delays in diagnosis and outcomes. Methods We identified patients presenting to a hip specialist with a new diagnosis of hip dysplasia. The time taken between patients presenting to their general practitioner and attending the young adult hip clinic was established. Patients were stratified into Early, Moderate and Late Referral groups. Hip and SF-12 questionnaires were completed. Radiographs were graded according to the Tönnis classification system and the outcome following hip specialist review documented. Results Fifty-one patients were identified. Mean time from attending a general practitioner to review at the young adult hip clinic was 40.4 months. Lower hip and SF-12 scores, and higher radiological osteoarthritis grades were found in the Moderate and Late Referral groups. A higher proportion of the Moderate and Late Referral group underwent total hip arthroplasty rather than periacetabular osteotomy. Conclusion Delays in referring a patient to a hip specialist are associated with poorer outcomes. We propose pelvic radiographs are requested early by general practitioners to allow prompt diagnosis and referral to a hip specialist.
Diagnostic value of apparent diffusion coefficient in differentiating between high-grade gliomas and brain metastases
Authors: Caravan Ionut , Ciortea Cristiana Augusta , Contis Alexandra , Lebovici Andrei 
Published: August 2017

Background High-grade gliomas (HGGs) and brain metastases (BMs) can display similar imaging characteristics on conventional MRI. In HGGs, the peritumoral edema may be infiltrated by the malignant cells, which was not observed in BMs. Purpose To determine whether the apparent diffusion coefficient values could differentiate HGGs from BMs. Material and Methods Fifty-seven patients underwent conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) before treatment. The minimum and mean ADC in the enhancing tumor (ADCmin, ADCmean) and the minimum ADC in the peritumoral region (ADCedema) were measured from ADC maps. To determine whether there was a statistical difference between groups, ADC values were compared. A receiver operating characteristic (ROC) curve analysis was used to determine the cutoff ADC value for distinguishing between HGGs and BMs. Results The mean ADCmin values in the intratumoral regions of HGGs were significantly higher than those in BMs. No differences were observed between groups regarding ADCmean values. The mean ADCmin values in the peritumoral edema of HGGs were significantly lower than those in BMs. According to ROC curve analysis, a cutoff value of 1.332 × 10−3 mm2/s for the ADCedema generated the best combination of sensitivity (95%) and specificity (84%) for distinguishing between HGGs and BMs. The same value showed a sensitivity of 95.6% and a specificity of 100% for distinguishing between GBMs and BMs. Conclusion ADC values from DWI were found to distinguish between HGGs and solitary BMs. The peritumoral ADC values are better than the intratumoral ADC values in predicting the tumor type.
Molecular microdeletion analysis of infertile men with karyotypic Y chromosome abnormalities
Authors: Pan Yuan , Zhang Hong-guo , Xi QI , Zhang Han , Wang Rui-xue , Li Lei-lei , Liu Rui-zhi 
Published: August 2017

Objectives To investigate azoospermic factor (AZF) microdeletions in infertile men from northeastern China with karyotypic Y chromosome abnormalities. Methods G-banding of metaphase chromosomes and karyotype analysis were performed in all infertile male patients. Genomic DNA was isolated and used to analyze classical AZF microdeletions by PCR. The regions and sequence-tagged sites of AZFa (SY86, SY84), AZFb (SY127, SY134, SY143), and AZFc (SY152, SY254, SY255, SY157) were sequenced by multiplex PCR. Results A total of 190 Y chromosome abnormality carriers were found, of whom 35 had AZF microdeletions. These were most common in 46,X,Yqh− patients, followed by 45,X/46,XY patients. Most microdeletions were detected in the AZFb + c region, including 48.57% of all AZF microdeletion cases. AZF partial deletions were also seen in these patients. Overall, AZF microdeletions were detected in 38.5% Y chromosome abnormality carriers, and most were observed in 46,X,Yqh− individuals. Loss of SY152 was seen in all 35 patients, with SY254/SY255 detected in 34 of 35 patients. Conclusions AZF microdeletions were detected in 38.5% of Y chromosome abnormality carriers. This indicates that AZF microdeletion screening is advisable for individuals with karyotypic Y chromosome abnormalities.
Comparative effects of traditional Chinese and Western migraine medicines in an animal model of nociceptive trigeminovascular activation
Authors: Zhao Yonglie , Martins-Oliveira Margarida , Akerman Simon , Goadsby Peter J 
Published: August 2017

Background Migraine is a highly prevalent and disabling disorder of the brain with limited therapeutic options, particularly for preventive treatment. There is a need to identify novel targets and test their potential efficacy in relevant preclinical migraine models. Traditional Chinese medicines have been used for millennia and may offer avenues for exploration. Methods We evaluated two traditional Chinese medicines, gastrodin and ligustrazine, and compared them to two Western approaches with propranolol and levetiracetam, one effective and one ineffective, in an established in vivo rodent model of nociceptive durovascular trigeminal activation. Results Intravenous gastrodin (30 and 100 mg/kg) significantly inhibited nociceptive dural-evoked neuronal firing in the trigeminocervical complex. Ligustrazine (10 mg/kg) and propranolol (3 mg/kg) also significantly inhibited dural-evoked trigeminocervical complex responses, although the timing of responses of ligustrazine does not match its pharmacokinetic profile. Levetiracetam had no effects on trigeminovascular responses. Conclusion Our data suggest gastrodin has potential as an anti-migraine treatment, whereas ligustrazine seems less promising. Interestingly, in line with clinical trial data, propranolol was effective and levetiracetam not. Exploration of the mechanisms and modelling effects of Chinese traditional therapies offers novel route for drug discovery in migraine.
Adjacent Joint Kinematics After Ankle Arthrodesis During Cadaveric Gait Simulation
Authors: Sturnick Daniel R. , Demetracopoulos Constantine A. , Ellis Scott J. , Queen Robin M. , Kolstov Jayme C. B. , Deland Jonathan T. , Baxter Josh R. 
Published: August 2017

Background: Arthrodesis is an effective and reliable treatment for end-stage ankle arthritis; however, many patients develop ipsilateral adjacent joint arthritis following surgery. The mechanism that drives adjacent joint arthritis remains uncertain. Cadaveric simulation permits direct investigation of the effects of both arthrodesis and movement strategy on adjacent joints during simulated walking. The objective of this study was to identify the isolated effect of ankle arthrodesis on adjacent joint kinematics during simulated walking. Methods: Effects of ankle arthrodesis on adjacent joint kinematics were assessed in 8 cadaveric foot and ankle specimens using a robotic gait simulator. Gait parameters acquired from healthy adults and patients with ankle arthrodesis were used as inputs for simulations. Three-dimensional subtalar and talonavicular joint kinematics were directly measured before and after ankle arthrodesis, and healthy- and arthrodesis-gait parameters were applied to identify the isolated effect of the ankle arthrodesis on adjacent joint kinematics. Results: Ankle arthrodesis increased subtalar and talonavicular joint motion during early and midstance independent of which gait parameters were used as inputs to the gait simulator. However, adjacent joint motions did not differ between the control and arthrodesis condition during late stance, when the healthy gait parameters were used as inputs. Conversely, adjacent joint motion decreased during late stance following arthrodesis when simulating gait using parameters typical in arthrodesis patients. Conclusions: Regardless of the gait parameter inputs, subtalar and talonavicular joint motions increased from normal kinematics, which likely increase the biomechanical burden placed on these adjacent joints and may lead to joint degeneration. Clinical Relevance: Increased motion of the adjacent joints caused by ankle arthrodesis may explain the articular degeneration observed clinically.
A nationwide analysis of 30-day readmissions related to critical limb ischemia
Authors: Masoomi Reza , Shah Zubair , Quint Clay , Hance Kirk , Vamanan Karthik , Prasad Anand , Hoel Andrew , Dawn Buddhadeb , Gupta Kamal 
Published: August 2017

Objectives There is paucity of information regarding critical limb ischemia-related readmission rates in patients admitted with critical limb ischemia. We studied 30-day critical limb ischemia-related readmission rate, its predictors, and clinical outcomes using a nationwide real-world dataset. Methods We did a secondary analysis of the 2013 Nationwide Readmissions Database. We included all patients with a primary diagnosis of extremity rest pain, ulceration, and gangrene secondary to peripheral arterial disease. From this group, all patients readmitted with similar diagnosis within 30 days were recorded. Results Of the total 25,111 index hospitalization for critical limb ischemia, 1270 (5%) were readmitted with a primary diagnosis of critical limb ischemia within 30 days. The readmission rate was highest (9.5%) for the group that did not have any intervention (revascularization or major amputation) and was lowest for surgical revascularization and major amputation groups (2.6% and 1.3%, P value <0.001 for all groups). Severity of critical limb ischemia at index admission was associated with a significantly higher rate of 30-day readmission. Critical limb ischemia-related readmission was associated with a higher rate of major amputation (29.6% vs. 16.2%, P<0.001), a lower rate of any revascularization procedure (46% vs. 62.6%, P<0.001), and a higher likelihood of discharge to a skilled nursing facility (43.2% vs. 32.2%, P<0.001) compared to index hospitalization. Conclusions In patients with primary diagnosis of critical limb ischemia, 30-day critical limb ischemia-related readmission rate was affected by initial management strategy and the severity of critical limb ischemia. Readmission was associated with a significantly higher rate of amputation, increased length of stay, and a more frequent discharge to an alternate care facility than index admission and thus may serve as a useful quality of care metric in critical limb ischemia patients.
Phase 1 clinical trial using mbIL21 ex vivo–expanded donor-derived NK cells after haploidentical transplantation
Authors: Ciurea Stefan O. , Schafer Jolie R. , Bassett Roland , Denman Cecele J. , Cao Kai , Willis Dana , Rondon Gabriela , Chen Julianne , Soebbing Doris , Kaur Indreshpal , Gulbis Alison , Ahmed Sairah , Rezvani Katayoun , Shpall Elizabeth J. , Lee Dean A. , Champlin Richard E. 
Published: August 2017

Abstract
Relapse has emerged as the most important cause of treatment failure after allogeneic hematopoietic stem cell transplantation (HSCT). To test the hypothesis that natural killer (NK) cells can decrease the risk of leukemia relapse, we initiated a phase 1 dose-escalation study of membrane-bound interleukin 21 (mbIL21) expanded donor NK cells infused before and after haploidentical HSCT for high-risk myeloid malignancies. The goals were to determine the safety, feasibility, and maximum tolerated dose. Patients received a melphalan-based reduced-intensity conditioning regimen and posttransplant cyclophosphamide-based graft-versus-host disease (GVHD) prophylaxis. NK cells were infused on days −2, +7, and +28 posttransplant. All NK expansions achieved the required cell number, and 11 of 13 patients enrolled received all 3 planned NK-cell doses (1 × 105/kg to 1 × 108/kg per dose). No infusional reactions or dose-limiting toxicities occurred. All patients engrafted with donor cells. Seven patients (54%) developed grade 1-2 acute GVHD (aGVHD), none developed grade 3-4 aGVHD or chronic GVHD, and a low incidence of viral complications was observed. One patient died of nonrelapse mortality; 1 patient relapsed. All others were alive and in remission at last follow-up (median, 14.7 months). NK-cell reconstitution was quantitatively, phenotypically, and functionally superior compared with a similar group of patients not receiving NK cells. In conclusion, this trial demonstrated production feasibility and safety of infusing high doses of ex vivo–expanded NK cells after haploidentical HSCT without adverse effects, increased GVHD, or higher mortality, and was associated with significantly improved NK-cell number and function, lower viral infections, and low relapse rate posttransplant.
Efficacy and safety of intragastric balloon in the treatment of obesity in adolescent females
Authors: Pezzo Cynthia Teixeira , de Souza Thiago Ferreira , Fenero Vinícius , Suano-Souza Fabíola Isabel , Grecco Eduardo , Sarni Roseli Oselka Saccardo 
Published: August 2017

Abstract
Background
The aims of this study are to evaluate the efficacy and safety of intragastric balloon (IB) to reduce the weight and body mass index (BMI) in severely obese adolescent females and to describe the changes in the liver enzymes and lipid and glucose metabolism biomarkers.

Methods
This study included 10 severely obese post-menarche adolescent females. We evaluated anthropometric data, lipid profile, glucose metabolism biomarkers, and liver enzymes before insertion and after removal of the IB.

Results
BMI and weight reduction were larger during the first month of intervention. Especially in the first week, there was a reduction of 1.74 ± 0.46 kg/m2 (p = 0.004) and 6.46 ± 1.52 kg (p = 0,002), respectively. After 3 months, there was an average BMI reduction of 4.29 ± 1.04 kg/m (p = 0.005) and weight reduction of 12.9 ± 3.08 kg (p = 0.004). From the initial moment to study conclusion, there was a statistically significant reduction in insulin levels (9.0 ± 2.8 U/mL; p = 0.012) and in homeostatic model assessment-insulin resistance (2.0 ± 0.6; p = 0.009). Five patients reported, during the first week, epigastric pain; nausea and vomiting were observed in two patients. No adolescents presented dysphagia during IB use.

Conclusion
IB use in adolescent females with severe obesity in association with a conservative multidisciplinary treatment had a positive impact in BMI reduction, with few adverse effects. There was also an improvement in insulin resistance.
Pengaruh Kebiasaan Belajar Dan Kreativitas Belajar Siswa Terhadap Hasil Belajar Matematika (Survey Pada SMA Di Kecamatan Ciledug Tangerang)
Authors: Nurdeni Nurdeni , Liberna Hawa 
Published: August 2017

The objective of this research is to investigate the influence of students learning activity and creativity toward the math learning achievement. In addition it is to know simultaneously the influence of students learning activity and creativity toward the math learning achievement. The research method is used in this research is survey. There are 60 students come from tenth grader of SMA Numaniyah and SMA Fatahillah Ciledug Tangerang as sample of the research, interview, questionner, and achievement test are used to collect the data. The descriptive statistical is used to analyze the data beside person double correlation coefficient, determination coefficient and regression analysis T and F test are used to incate the statistical test. The research was conducted on March 2012. The result of the research show that there is simultaneous influence between students learning activity and creativity toward the math learning achievement of tenth grader students at SMA Ciledug Tangerang. It is stated by the quality regression of Y = -6,227 + 0,85 + 0,683. It indicates that one level of improvement of learning activity and creativity will be followed by the students achievement of -6,227. The students learning activity and creativity variables indicates the significance influence toward the students learning achievement. It is shownby the determination coefficient of R2 = 0,777 and F test score = 99,459.
Aplikasi Persamaan Bessel Orde Nol Pada Persamaan Panas Dua Dimensi
Authors: Mulyati Annisa Eki , Sugiyanto Sugiyanto 
Published: August 2017

Bessel differential equation is one of the applied equation in physics is about heat transfer. Application of modified Bessel function of order zero on heat transfer process of two-dimensional objects which can be modelled in the form of a two-order partial differential equations as follows, ..... With the obtained solutions of Bessel's differential equation application of circular fin, .... two-dimensional temperature stated on the point ..... against time t
Aplikasi Algoritma Branch and Bound Untuk Optimasi Jalur Pemadam Kebakaran Kota Yogyakarta
Authors: Margiyani Sri , Mussafi Noor Saif Muhammad 
Published: August 2017

Kasus kebakaran di Indonesia, khususnya Kota Yogyakarta dari tahun ke tahun masih menunjukkan angka yang tinggi. Hal ini mengakibatkan kerugian yang cukup tinggi bagi korban kebakaran. Untuk meminimalisasi terjadinya korban jiwa dan kerugian secara material saat terjadi kebakaran, maka pihak pemadam kebakaran mengupayakan melalui rute terpendek untuk sampai di lokasi kebakaran. Tujuan dari penelitian ini adalah pencarian rute terpendek jalur pemadam kebakaran dari kantor pemadam sampai ke lokasi kebakaran. Permasalahan pencarian rute terpendek jalur pemadam kebakaran secara abstrak dapat digambarkan dengan suatu graf yang merupakan masalah optimasi dalam pencarian rute terpendek (Shortest Path Problem). Pemecahan permasalahan tersebut adalah dengan merepresentasikan peta pemadam kebakaran ke dalam bentuk graf berbobot dan berarah, selanjutnya permasalahan diselesaikan menggunakan Algoritma Branch and Bound. Perhitungan dilakukan secara manual dengan jarak (dalam meter) sebagai bobot perhitungan. Berdasarkan perhitungan menggunakan Algoritma Branch and Bound untuk optimasi jalur pemadam kebakaran Kota Yogyakarta untuk wilayah Kecamatan Umbulharjo menghasilkan solusi rute: Kantor pemadam kebakaran – Jln. Ipda Tut Harsono - Jln. Kusumanegara – Jln. Glagahsari – Kantor Kecamatan Umbulharjo) dengan total jarak 5305 meter atau 5,035 km.
The First Manifestation of a Left Atrial Myxoma as a Consequence of Multiple Left Coronary Artery Embolisms
Authors: Novak Martin , Fila Petr , Hlinomaz Ota , Zampachova Vita 
Published: August 2017

Abstract
A case of multiple embolisms in the left coronary artery as a rare first manifestation of left atrial myxoma is reported. A patient with embolic myocardial infarction and congestive heart failure was treated by percutaneous aspirations and balloon dilatations. Transesophageal echocardiography disclosed a villous myxoma with high embolic potential. Surgical resection of the tumour, suturing of a patent foramen ovale suture and an annuloplasty of the dilated tricuspid annulus was performed the third day after the admission. Recovery of the documented left ventricular systolic function can be explained by resorption of myxomatous material. The patient was discharged ten days after the surgery.
Use of Transcranial Doppler in Intensive Care Unit
Authors: Viski Sandor , Olah Laszlo 
Published: August 2017

Abstract
Use of transcranial Doppler has undergone much development since its introduction in 1982, making the technique suitable for general use in intensive care units. The main application in intensive care units is to assess intracranial pressure, confirm the lack of cerebral circulation in brain death, detect vasospasm in subarachnoid haemorrhage, and monitor the blood flow parameters during thrombolysis and carotid endarterectomy, as well as measuring stenosis of the main intracranial arteries in sickle cell disease in children. This review summarises the use of transcranial Doppler in intensive care units.
Game Analysis in a Dual Channels System with Different Power Structures and Service Provision
Authors: Zhang Guoxing , Fang Shuai , Lai Kin Keung 
Published: August 2017

AbstractThis paper studies a dual-channel supply chain in which a manufacturer sells products to a retailer as well as to customers who are sensitive to both channel price and the retail service. Three game models (Manufacturer Stackelberg, Retailer Stackelberg and Vertical Nash) are built according to members’ different bargaining power in a dual channels system. The authors show that customers can receive lower channel price and higher retail service level when channel members have equal bargaining power, however, when the retailer occupies the market leadership, consumers always receive the least welfare because of the higher channel price and lower retail service. Interestingly, the retailer can take advantage of market leadership to make more profits, while the manufacturer is more willing to give up its power and act as a Stackelberg follower. Furthermore, Manufacturer Stackelberg and Vertical Nash is a strictly dominated strategy for the retailer and the manufacturer respectively.
Uniform Parallel Machine Scheduling Problem with Controllable Delivery Times
Authors: Li Kai , Li Hui , Cheng Bayi , Luo Qing 
Published: August 2017

AbstractThis paper considers the uniform parallel machine scheduling problem with controllable delivery times, which assumes that the delivery times of jobs are linear decreasing functions of the consumed resource. It aims to minimize the maximum completion time under the constraint that the total resource consumption does not exceed a given limit. For this NP-hard problem, we propose a resource allocation algorithm, named RAA, according to the feasible solution of the uniform parallel machine scheduling problem with fixed delivery times. It proves that RAA algorithm can obtain the optimal resource allocation scheme for any given scheduling scheme inO(nlogn)time. Some algorithms based on heuristic algorithm LDT, heuristic algorithm LPDT and simulated annealing are proposed to solve the uniform parallel machine scheduling problem with controllable delivery times. The accuracy and efficiency of the proposed algorithms are tested based on those data with problem sizes varying from 40 to 200 jobs and 2 to 8 machines. The computational results indicate that the SA approach is promising and capable of solving large-scale problems in a reasonable time.