bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alarming consequences – autoinflammatory disease spectrum due to mutations in proline-serine-threonine phosphatase-interacting protein 1
Authors: Holzinger Dirk , Roth Johannes 
Published: July 2016

Purpose of review
To give an overview about the expanding spectrum of autoinflammatory diseases due to mutations in proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) and new insights into their pathogenesis.

Recent findings
In addition to classical pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome, PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome has been described as a distinct clinical phenotype of PSTPIP1-associated inflammatory diseases (PAID) and other entities are emerging. In addition to dysregulation of IL-1ß release from activated PAPA monocytes that requires NLR family, pyrin domain containing 3 (NLRP3), PSTPIP1 mutations have an general impact on cellular dynamics of cells of the innate immune system. In addition, overwhelming expression and release of the alarmins myeloid-related protein (MRP) 8 and 14 by activated phagocytes and keratinocytes, which promote innate immune mechanisms in a Toll like receptor (TLR) 4-dependent manner, are a characteristic feature of these diseases and form a positive feed-back mechanism with IL-1ß.

Summary
Autoinflammatory diseases due to PSTPIP1 mutations are not restricted to the classical PAPA phenotype but might present with other distinct clinical features. MRP8/14 serum levels are a hallmark of PAPA and PAMI and can be used as screening tool to initiate targeted genetic testing in suspected cases. The feedback mechanism of IL-1ß and MRP-alarmin release may offer novel targets for future therapeutic approaches.
Filler Rhinoplasty Evaluated by Anthropometric Analysis
Authors: Youn Sung Hwan , Seo Kyle K. 
Published: July 2016

BACKGROUND
There are no reports of objectively evaluating the efficacy of filler rhinoplasty by anthropometric techniques.

OBJECTIVE
To objectively demonstrate the effectiveness of filler rhinoplasty by anthropometric analysis.

MATERIALS AND METHODS
A total of 242 patients who revisited the clinic within 2 months of undergoing hyaluronic acid filler rhinoplasty were analyzed based on the injection site, injected volume, and the change in anthropometry.

RESULTS
Among the 242 patients, 112 (46.3%) were in the nasal dorsum augmentation group, 8 (3.3%) were in the tip rotation group, and 122 (50.4%) were in the whole nose augmentation group. Average injection volume was 1 ± 0.4 mL for nasal dorsum and 0.9 ± 0.3 mL for tip rotation, whereas 1.6 ± 0.5 mL was used for whole nose augmentation. On follow-up, the radix height, nasofrontal angle, and nasolabial angle (NLA) had increased by 78.3%, 5.7 ± 4.1°, and 9.4 ± 4.5°, respectively, whereas the modified nasofacial angle had decreased by 1.9 ± 2.9°. Three cases (1.2%) of vascular complications were encountered.

CONCLUSION
Filler rhinoplasty is a simple and effective treatment modality producing outcomes comparable with surgical augmentation rhinoplasty. Among various anthropometric measurements, the nasal radix height was the most useful for evaluating dorsum augmentation, whereas the NLA was the best for nasal tip rotation.
Reporting Guidelines for Health Care Simulation Research
Authors: Cheng Adam , Kessler David , Mackinnon Ralph , Chang Todd P. , Nadkarni Vinay M. , Hunt Elizabeth A. , Duval-Arnould Jordan , Lin Yiqun , Cook David A. , Pusic Martin , Hui Joshua , Moher David , Egger Matthias , Auerbach Marc 
Published: July 2016

Introduction
Simulation-based research (SBR) is rapidly expanding but the quality of reporting needs improvement. For a reader to critically assess a study, the elements of the study need to be clearly reported. Our objective was to develop reporting guidelines for SBR by creating extensions to the Consolidated Standards of Reporting Trials (CONSORT) and Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statements.

Methods
An iterative multistep consensus-building process was used on the basis of the recommended steps for developing reporting guidelines. The consensus process involved the following: (1) developing a steering committee, (2) defining the scope of the reporting guidelines, (3) identifying a consensus panel, (4) generating a list of items for discussion via online premeeting survey, (5) conducting a consensus meeting, and (6) drafting reporting guidelines with an explanation and elaboration document.

Results
The following 11 extensions were recommended for CONSORT: item 1 (title/abstract), item 2 (background), item 5 (interventions), item 6 (outcomes), item 11 (blinding), item 12 (statistical methods), item 15 (baseline data), item 17 (outcomes/estimation), item 20 (limitations), item 21 (generalizability), and item 25 (funding). The following 10 extensions were recommended for STROBE: item 1 (title/abstract), item 2 (background/rationale), item 7 (variables), item 8 (data sources/measurement), item 12 (statistical methods), item 14 (descriptive data), item 16 (main results), item 19 (limitations), item 21 (generalizability), and item 22 (funding). An elaboration document was created to provide examples and explanation for each extension.

Conclusions
We have developed extensions for the CONSORT and STROBE Statements that can help improve the quality of reporting for SBR.
A 2-Year Evaluation of Quality of Life Outcomes of Patients With Pelvic Organ Prolapse Treated With an Elevate Prolapse Repair System
Authors: Buca Danilo Italo Pio , Leombroni Martina , Falò Eleonora , Bruno Matteo , Santarelli Alessandro , Frondaroli Franco , Liberati Marco , Fanfani Francesco 
Published: July 2016

Objectives
To evaluate 2-year quality of life of women with pelvic organ prolapse submitted to prosthetic correction with Elevate.

Methods
We enrolled 116 consecutive patients with a stage ≥ to 2 prolapse. The Prolapse Quality of Life questionnaire was administered in the preoperative time and after 2 years of follow-up. The statistical results were obtained by using the SPSS Advanced Statistical™ 11.0 Software.

Results
Patient's quality of life improved substantially following prosthetic vaginal surgery. In particular, a clear improvement in the “general state of patients health” (P < 0.05), and a reduction in the daily physical, social, and psychological quality of life (P < 0.05) connected to the prolapse of pelvic organ were observed. Furthermore, a significant reduction in the percentage of patients with urinal disturbances (86.2% preoperative vs 20.7% postoperative; P < 0.05), and an improvement in patient's relations with their partners with 12 patients resuming sexual activity were found.

Conclusions
This study demonstrates that prosthetic vaginal correction represents a long-term efficient clinical instrument for women with symptomatic pelvic organ prolapse. It also achieves a resolution for urinary symptomatology and embarrassment, social limitation, physical and psychological difficulties of women, which, in great part, resulted in many overcoming surgical therapy, worried about fixed outcomes.
Real-time image-content-based beamline control for smart 4D X-ray imaging
Authors: Vogelgesang Matthias , Farago Tomas , Morgeneyer Thilo F. , Helfen Lukas , dos Santos Rolo Tomy , Myagotin Anton , Baumbach Tilo 
Published: July 2016

Real-time processing of X-ray image data acquired at synchrotron radiation facilities allows for smart high-speed experiments. This includes workflows covering parameterized and image-based feedback-driven control up to the final storage of raw and processed data. Nevertheless, there is presently no system that supports an efficient construction of such experiment workflows in a scalable way. Thus, here an architecture based on a high-level control system that manages low-level data acquisition, data processing and device changes is described. This system is suitable for routine as well as prototypical experiments, and provides specialized building blocks to conduct four-dimensionalin situ,in vivoandoperandotomography and laminography.
Managers’ motives for investing in HR practices and their implications for public service motivation
Authors: Gould-Williams Julian Seymour 
Published: July 2016

Purpose– The purpose of this paper is to explain how approaches to human resource management may contribute to the development of public service motivation (PSM). Three different approaches to managing people are outlined, namely, the “high performance”, “high commitment” and “high involvement”. Relevant theories are then used to predict the outcomes and relevance of the different approaches when promoting PSM in public sector organisations.Design/methodology/approach– This is a theoretical paper.Findings– This paper provides the first theoretical explanations for the relationships between human resource (HR) practices and PSM in public sector organisations.Originality/value– This paper explains how the same HR practices may have different employee outcomes depending on managers’ motivations for implementing them.
From compliance to commitment
Authors: Prysmakova Palina 
Published: July 2016

Purpose– Building on institutional theories, the purpose of this paper is to test the relationship of organizational centralization and public service motivation (PSM), and to explore country’s centralization effect on it.Design/methodology/approach– The quantitative analysis of 390 responses from 42 social care and labor market public service providers operating in two countries with opposite administrative regimes – decentralized Poland and centralized Belarus.Findings– The Polish sample confirms previous observations. Organizational centralization correlates with PSM, while PMS dimensions do not act in concert. In contrast to others, self-sacrifice is positively associated with increased centralization. A country’s context has a strong mediating effect. The Belarusian sample revealed no relationship between organizational centralization and PSM. Because the main difference with Poland lies in the politico-administrative organization of the public sector, the findings suggest further examination of the county’s centralization effects. Democracy is not an imperative for higher PSM. Belarusian employees scored higher than the Polish on attraction to public service. Centralization of state administration does not necessarily indicate higher centralization in separate executive units. Polish organizations scored similar or higher on the questions of organizational centralization.Research limitations/implications– Context factors correlate differently with separate PSM dimensions, therefore, researchers should always look at PSM as a complex concept. Robust assertions about country’s centralization effect will require further tests on a larger sample of countries with different administrative regimes.Practical implications– Human resource (HR) managers in decentralized Poland could modify employees’ PSM behavior by altering the centralization level of an organization. In highly centralized Belarus, employees’ PSM is less responsive to centralization changes, thus, HR managers should recruit individuals with the initially high PSM.Originality/value– First PSM study with the primary data collected in a non-democratic country; first study to simultaneously address centralization on organizational and country levels.
Dynamic range boxes – a robust nonparametric approach to quantify size and overlap of n‐dimensional hypervolumes
Authors: Junker Robert R. , Kuppler Jonas , Bathke Arne C. , Schreyer Manuela L. , Trutschnig Wolfgang 
Published: July 2016

Summary

n‐dimensional hypervolumes are commonly applied in ecology and evolutionary studies to describe and compare niches, trait spaces characterizing phenotypes or the functional composition of communities. Classical ecological surveys, modern analytical tools and the establishment of online data bases will produce large multivariate data sets, which demands robust statistical tools to analyse and interpret hypervolumes.

Existing approaches often have weaknesses; for example, they rely on multivariate normally or elliptically distributed data, perform poorly in higher dimensions, or their outputs vary arbitrarily with parameter choice. Here we introduce dynamic range boxes as a robust nonparametric approach to quantify size and overlap of n‐dimensional hypervolumes.

Dynamic range boxes (implemented in the r package dynRB) improve the concept of multivariate range boxes by accounting for the distribution of the data within their range, while still no assumptions on the underlying distributions are needed. In addition to calculating the whole n‐dimensional hypervolume, the package dynRB also provides functions for a coordinate‐wise analysis and interpretation of the data.

The concept of dynamic range boxes reliably computes sizes and overlaps of n‐dimensional hypervolumes, which makes dynamic range boxes readily applicable for a broad range of data sets to answer questions related to various disciplines.
Slow pupillary light responses in infants at high risk of cerebral palsy were associated with periventricular leukomalacia and neurological outcome
Authors: Hamer Elisa G. , Vermeulen R. Jeroen , Dijkstra Linze J. , Hielkema Tjitske , Kos Claire , Bos Arend F. , Hadders‐Algra Mijna 
Published: July 2016

AbstractAimHaving observed slow pupillary light responses (PLRs) in infants at high risk of cerebral palsy, we retrospectively evaluated whether these were associated with specific brain lesions or unfavourable outcomes.MethodsWe carried out neurological examinations on 30 infants at very high risk of cerebral palsy five times until the corrected age of 21 months, classifying each PLR assessment as normal or slow. The predominant reaction during development was determined for each infant. Neonatal brain scans were classified based on the type of brain lesion. Developmental outcome was evaluated at 21 months of corrected age with a neurological examination, the Bayley Scales of Infant Development Second Edition and the Infant Motor Profile.ResultsOf the 30 infants, 16 developed cerebral palsy. Predominantly slow PLRs were observed in eight infants and were associated with periventricular leukomalacia (p = 0.007), cerebral palsy (p = 0.039), bilateral cerebral palsy (p = 0.001), poorer quality of motor behaviour (p < 0.0005) and poorer cognitive outcome (p = 0.045).ConclusionThis explorative study suggested that predominantly slow PLR in infants at high risk of cerebral palsy were associated with periventricular leukomalacia and poorer developmental outcome. Slow PLR might be an expression of white matter damage, resulting in dysfunction of the complex cortico‐subcortical circuitries.
Timor‐Leste's demographic challenges for environment, peace and nation building
Authors: Hosgelen Merve , Saikia Udoy 
Published: July 2016

AbstractTimor‐Leste's nation‐building process faces significant demographic challenges because of its current and prospective population dynamics. Based on the 2010 census data this paper projects the demographic structure of Timor‐Leste by 2030 and discusses the impact of the same on peace, development and environmental sustainability. This paper projects that Timor‐Leste's population will increase from 1.06 million in 2010 to 1.82 million in 2030, and because of a slow decline in total fertility rates, its population characteristics will remain that of a very youthful country with an extraordinarily high dependency ratio. Timor‐Leste will have extremely high proportion of excess labour, high concentration of uneducated and jobless youth in small urban areas and an ever‐increasing demand on natural resources in the next two decades. In the context of poor performing domestic economy, very low formal sector employment and weak environmental governance, these challenges may well contribute to social conflict which is evident in the nation's recent past. This paper is an attempt to reflect upon the implications of Timor‐Leste's population dynamics by 2030 on urbanisation, economy (labour market) and the environment which tend to have a strong relationship with social stability.
Sparking development or consuming the countryside? Lao charcoal commodity networks in the Mekong Region
Authors: Barney Keith 
Published: July 2016

AbstractOne of the unexpected outcomes of increased regional integration in southern Laos has been a boom in household production and roadside sale of wood charcoal. This paper develops an ethnographically informed analysis of charcoal as a socially embedded market, providing insights into the sociopolitical relations of access, legal and extra‐legal regulations, and the distribution of rents that characterise this trade. Contrary to some assumptions about charcoal as a necessarily exploitative commodity, this paper points to some of the advantageous income smoothing opportunities that charcoal presents for many rural Lao households and detail the complex ways in which charcoal production can relate to forest sustainability and degradation. The paper elaborates a perspective of entrepreneurial Lao charcoal communities, energetically utilising locally available natural resources, for direct cash income. Charcoal production networks also connect everyday household livelihoods in Laos to large‐scale extractive industry, in ways that have been arguably underemphasised previously. At the same time, the charcoal trade highlights the structural limits to notions of smallholder agency and local participation in commodified market relations, within broader political‐economic contexts decidedly shaped through uneven development, and accumulation through dispossession.
Discovery of neurotrophic agents based on hydroxycinnamic acid scaffold
Authors: Hosseini Razieh , Moosavi Fatemeh , Rajaian Hamid , Silva Tiago , Magalhães e Silva Diogo , Soares Pedro , Saso Luciano , Edraki Najmeh , Miri Ramin , Borges Fernanda , Firuzi Omidreza 
Published: July 2016

The number of people affected by neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease is rapidly increasing owing to the global increase in life expectancy. Small molecules with neurotrophic effects have great potential for management of these neurological disorders. In this study, different (C1–C12) alkyl ester derivatives of hydroxycinnamic acids (HCAs) were synthesized (a total of 30 compounds). The neurotrophic capacity of the test compounds was examined by measuring promotion of survival in serum‐deprived conditions and enhancement of nerve growth factor (NGF)‐induced neurite outgrowth in PC12 neuronal cells. p‐Coumaric, ferulic, and sinapic acids and their esters did not alter cell survival, while caffeic acid and all its alkyl esters, especially decyl and dodecyl caffeate, significantly promoted neuronal survival at 25 μm. Methyl, ethyl, propyl, and butyl caffeate esters also significantly enhanced NGF‐induced neurite outgrowth, among which the most effective ones were propyl and butyl esters, which at 5 μm led to 25‐ and 22‐fold increases in the number of neurites, respectively. The findings of the docking study suggested phosphatidylinositol 3‐kinase (PI3K) as the potential molecular target. In conclusion, our findings demonstrate that alkyl esters of caffeic acid can be useful as scaffolds for the discovery of therapeutic agents for neurodegenerative diseases.
Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice
Authors: Yamakawa M , Ouhara K , Kajiya M , Munenaga S , Kittaka M , Yamasaki S , Takeda K , Takeshita K , Mizuno N , Fujita T , Sugiyama E , Kurihara H 
Published: July 2016

Summary
Epidemiological studies have linked periodontitis to rheumatoid arthritis (RA). Porphyromonas gingivalis (Pg) was reported recently to produce citrullinated protein (CP) and increase anti-cyclic CP antibody (ACPA), both of which have been identified as causative factors of RA. In the present study, we determined the effects of Pg infection on the exacerbation of RA in a mouse model. RA model mice (SKG mice) were established by an intraperitoneal (i.p.) injection of laminarin (LA). Mice were divided into six groups, Ctrl (PBS injection), LA (LA injection), Pg/LA (Pg + LA injection), Pg (Pg injection), Ec/LA (Escherichia coli and LA injection) and Ec (E. coli injection). In order to evaluate RA, joint swelling by the arthritis score, bone morphology by microcomputed tomography (microCT), haematoxylin and eosin staining, ACPA, matrix metalloproteinase-3 (MMP-3) and cytokine level in serum by enzyme-linked immunosorbent assay were determined. Osteoclast differentiation from bone marrow mononuclear cells (BMCs) was examined to clarify the underlying mechanisms of RA. The presence of Pg and CP in joint tissue was also investigated. The arthritis score was threefold higher in the Pg/LA group than in the LA group. Severe bone destruction was observed in joint tissue of the Pg/LA group. A microCT analysis of the Pg/LA group revealed a decrease in bone density. ACPA, MMP-3, interleukin (IL)-2, IL-6, CXCL1 and macrophage inflammatory protein (MIP)-1α levels from the Pg/LA group were the highest. The osteoclastogenesis of BMCs was enhanced in the Pg/LA group. Furthermore, large amounts of Pg components and CP were detected in the Pg/LA group. In conclusion, Pg infection has the potential to exacerbate RA.
Peripheral blood flow changes in response to postexercise cold water immersion
Authors: Choo Hui C. , Nosaka Kazunori , Peiffer Jeremiah J. , Ihsan Mohammed , Yeo Chow C. , Abbiss Chris R. 
Published: July 2016

SummaryThis study compared the effect of postexercise water immersion (WI) at different temperatures on common femoral artery blood flow (CFA), muscle (total haemoglobin; tHb) and skin perfusion (cutaneous vascular conductance; CVC), assessed by Doppler ultrasound, near‐infrared spectroscopy (NIRS) and laser Doppler flowmetry, respectively. Given that heat stress may influence the vascular response during cooling, nine men cycled for 25 min at the first ventilatory threshold followed by intermittent 30‐s cycling at 90% peak power until exhaustion at 32·8 ± 0·4°C and 32 ± 5% RH. They then received 5‐min WI at 8·6 ± 0·2°C (WI9), 14·6 ± 0·3°C (WI15), 35·0 ± 0·4°C (WI35) or passive rest (CON) in a randomized, crossover manner. Heart rate (HR), mean arterial pressure (MAP), muscle (Tmu), thigh skin (Tthigh), rectal (Tre) and mean body (Tbody) temperatures were assessed. At 60 min postimmersion, decreases in Tre after WI35 (−0·6 ± 0·3°C) and CON (−0·6 ± 0·3°C) were different from WI15 (−1·0 ± 0·3°C; P<0·05), but not from WI9 (−1·0 ± 0·3°C; P = 0·074–0·092). WI9 and WI15 had reduced Tbody, Tthigh and Tmu compared with WI35 and CON (P <0·05). CFA, tHb and CVC were lower in WI9 and WI15 compared with CON (P<0·05). tHb following WI9 remained lower than CON (P = 0·044) at 30 min postimmersion. CVC correlated with tHb during non‐cooling (WI35 and CON) (r2 = 0·532; P<0·001) and cooling recovery (WI9 and WI15) (r2 = 0·19; P = 0·035). WI9 resulted in prolonged reduction in muscle perfusion. This suggests that CWI below 10°C should not be used for short‐term (i.e. <60 min) recovery after exercise.