bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the Clinical COPD Questionnaire: A systematic review
Authors: Zhou Zijing , Zhou Aiyuan , Zhao Yiyang , Chen Ping 
Published: January 2017

ABSTRACTThe Clinical COPD Questionnaire (CCQ) is recommended by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) to evaluate health status in patients with COPD. The objective of this work was to systemically assess the reliability, validity, responsiveness and minimum clinically important difference (MCID) of the CCQ. A structured search was conducted in three databases to identify articles that evaluated the psychometric properties of the CCQ in individuals with COPD. Two investigators screened the title, abstract and full text of the articles to determine study eligibility and performed the data extraction. Quality assessment of included studies was assessed by the COSMIN (Consensus‐Based Standards for the Selection of Health Measurement Instruments) checklist. Finally, 43 studies were included, over half of which had fair methodological quality. Internal consistency (reliability) of the CCQ total score ranged from 0.84 to 0.94, and test‐retest reliability was 0.70–0.99. The overall CCQ had a better correlation with St George's Respiratory Questionnaire (SGRQ; from 0.71 to 0.88) and COPD Assessment Test (CAT; from 0.64 to 0.88) than modified Medical Research Council (mMRC; from 0.392 to 0.668) and forced expiratory volume in 1 s (FEV1% predicted; from −0.31 to −0.68). Scores were different within GOLD stages, groups, composite events and co‐morbidities. CCQ was sensitive to exacerbations, pulmonary rehabilitation and smoking cessation with the MCID of 0.4. The CCQ is a very useful and practical tool that can be used in clinical populations with good reliability, validity and responsiveness to interventions.
How is physical activity measured in lung cancer?A systematic review of outcome measures and their psychometric properties
Authors: Edbrooke Lara , Denehy Linda , Parry Selina M. , Astin Ronan , Jack Sandy , Granger Catherine L. 
Published: January 2017

ABSTRACTPhysical activity (PA) levels are low in patients with lung cancer. Emerging evidence supports the use of interventions to increase PA in this population. We aimed to (1) identify and synthesize outcome measures which assess PA levels in patients with lung cancer and (2) to evaluate, synthesize and compare the psychometric properties of these measures. A systematic review of articles from searches was conducted of five electronic databases and personal records. Eligible studies were those which assessed PA using either performance‐based or patient‐reported measures. For aim 2, studies identified in aim 1 reporting on at least one psychometric property (validity, reliability, responsiveness or measurement error) were included. Two independent reviewers assessed eligibility and risk of bias with the COnsensus‐based Standards for the selection of health status Measurement INstruments.Thirty‐four studies using 21 different measures of PA were identified. Seventeen studies used performance‐based measures. The Godin Leisure Time Exercise Questionnaire (GLTEQ) was the most frequently used patient‐reported measure. Psychometric properties were reported for 13 of these measures and most frequently for movement sensors. Two studies reported on properties of the GLTEQ. Quality ratings for risk of bias were low. There is significant heterogeneity amongst studies regarding method of PA measurement along the lung cancer continuum. Greater consensus could be achieved by using a consensus approach such as a Delphi process. Future studies should include assessment of psychometric properties of the measurement tool being used. Currently, it is recommended where feasible, both performance‐based and patient‐reported measurements of PA should be undertaken.
Knee function among elite handball and football players 1‐6 years after anterior cruciate ligament injury
Authors: Myklebust G. , Bahr R. , Nilstad A. , Steffen K. 
Published: January 2017

The aim of the study was to describe objective and self‐reported knee function for athletes who have returned to elite handball and football play after an ACL injury, comparing these to non‐injured players at the same level. A total of 414 handball and 444 football players completed baseline tests from 2007 through 2014, examining lower extremity strength, dynamic balance, knee laxity, and knee function (KOOS questionnaire). Measures were compared between injured and non‐injured legs and between injured legs and legs of controls. Eighty (9.3%) of the 858 players reported a previous ACL injury, 1‐6 years post‐injury (3.5±2.5 years), 49 handball (61.3%) and 31 football players (38.7%). We found no difference in strength or dynamic balance between previously ACL‐injured (N=80) and non‐injured players legs (N=1556). However, lower quadriceps (6.3%, 95% CI: 3.2‐9.2) and hamstrings muscle strength (6.1%, 95% CI: 3.3‐8.1) were observed in previously ACL‐injured legs compared to the non‐injured contralateral side (N=80). ACL‐injured knees displayed greater joint laxity than the contralateral knee (N=80, 17%, 95% CI: 8‐26) and healthy knees (N=1556, 23%, 95% CI: 14‐33). KOOS scores were significantly lower for injured knees compared to knees of non‐injured players. ACL‐injured players who have successfully returned to elite sport have comparable strength and balance measures as their non‐injured teammates. Subjective perception of knee function is strongly affected by injury history, with clinically relevant lower scores for the KOOS subscores Pain, Function, Sport, and Quality Of Life.
Fast switch from extensional exhumation to thrusting of the Ronda Peridotites (South Spain)
Authors: Frasca Gianluca , Gueydan Frédéric , Poujol Marc , Brun Jean‐Pierre , Parat Fleurice , Monié Patrick , Pichat Alexandre , Mazier Sophie 
Published: January 2017

AbstractThe Alboran Domain, situated at the western end of the Mediterranean subduction system, is characterized by the Ronda Peridotites, one of the world's largest exposures of sub‐continental mantle. Using U–Pb (LA‐ICP‐MS) and Ar–Ar dating, we precisely dated two tectonic events associated with the Tertiary exhumation of the Ronda Peridotites. First, shearing along the Crust–Mantle Extensional Shear Zone caused, at ca. 22.5 Ma, mantle exhumation, local partial melting in the deep crust and coeval cooling in the upper crust. Second, the Ronda Peridotites Thrust triggered the final emplacement of the peridotites onto the continental crust at c. 21 Ma, as testified by granitic intrusions in the thrust hangingwall. The tectonic evolution of the western Alboran Domain is therefore characterized by a fast switch from continental lithospheric extension in a backarc setting, with sub‐continental mantle exhumation, to a rift inversion by thrusting driven by shortening of the upper plate.
Leeuwarden 2018: Complexity of Leisure‐Led Regional Development in A European Capital of Culture
Authors: Meekes Jasper F. , Buda Dorina M. , De Roo Gert 
Published: January 2017

AbstractLeeuwarden was chosen as European Capital of Culture (ECOC) for 2018. We address, through a complexity perspective, how leisure characteristics of the ECOC can affect regional development in Fryslân. Three aspects are identified that make leisure‐led regional development complex: (i) fragmentation of the leisure sector; (ii) balance between developing leisure and protecting existing social, cultural and ecological qualities; and (iii) difficulties obtaining crossovers between leisure and broader regional development. In an analysis of policy documents for the 2018 ECOC, we observe that although the interactions central to these complexities are recognised they are not captured in the monitoring of the ECOC effects through quantified targets such as attracting four million tourists. We argue that an approach that constantly acknowledges the interactions within leisure is required for a positive effect on regional development to emerge. This necessitates a process in which targets can be adapted according to changing circumstances.
Transposable elements (TEs) contribute to stress‐related long intergenic noncoding RNAs in plants
Authors: Wang Dong , Qu Zhipeng , Yang Lan , Zhang Qingzhu , Liu Zhi‐Hong , Do Trung , Adelson David L. , Wang Zhen‐Yu , Searle Iain , Zhu Jian‐Kang 
Published: January 2017

SummaryNoncoding RNAs have been extensively described in plant and animal transcriptomes by using high‐throughput sequencing technology. Of these noncoding RNAs, a growing number of long intergenic noncoding RNAs (lincRNAs) have been described in multicellular organisms, however the origins and functions of many lincRNAs remain to be explored. In many eukaryotic genomes, transposable elements (TEs) are widely distributed and often account for large fractions of plant and animal genomes yet the contribution of TEs to lincRNAs is largely unknown. By using strand‐specific RNA‐sequencing, we profiled the expression patterns of lincRNAs in Arabidopsis, rice and maize, and identified 47 611 and 398 TE‐associated lincRNAs (TE‐lincRNAs), respectively. TE‐lincRNAs were more often derived from retrotransposons than DNA transposons and as retrotransposon copy number in both rice and maize genomes so did TE‐lincRNAs. We validated the expression of these TE‐lincRNAs by strand‐specific RT‐PCR and also demonstrated tissue‐specific transcription and stress‐induced TE‐lincRNAs either after salt, abscisic acid (ABA) or cold treatments. For Arabidopsis TE‐lincRNA11195, mutants had reduced sensitivity to ABA as demonstrated by longer roots and higher shoot biomass when compared to wild‐type. Finally, by altering the chromatin state in the Arabidopsis chromatin remodelling mutant ddm1, unique lincRNAs including TE‐lincRNAs were generated from the preceding untranscribed regions and interestingly inherited in a wild‐type background in subsequent generations. Our findings not only demonstrate that TE‐associated lincRNAs play important roles in plant abiotic stress responses but lincRNAs and TE‐lincRNAs might act as an adaptive reservoir in eukaryotes.
Mitochondrial energetics and calcium coupling in the heart
Authors: Kohlhaas Michael , Nickel Alexander G. , Maack Christoph 
Published: January 2017

AbstractContraction and relaxation of the heart consume large amounts of energy that need to be replenished by oxidative phosphorylation in mitochondria, and matching energy supply to demand involves the complimentary control of respiration through ADP and Ca2+. In heart failure, an imbalance between ADP and Ca2+ leads to oxidation of mitochondrial pyridine nucleotides, where NADH oxidation may limit ATP production and contractile function, while NADPH oxidation can induce oxidative stress with consecutive maladaptive remodelling. Understanding the complex mechanisms that disturb this finely tuned equilibrium may aid the development of drugs that could ameliorate the progression of heart failure beyond the classical neuroendocrine inhibition.
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Identification of Merkel Cell Polyomavirus from a Patient with Acute Myeloid Leukemia
Authors: Song Y. , Gyarmati P. 
Published: January 2017

ABSTRACT
Merkel cell polyomavirus (MCPyV) is an oncogenic virus associated with Merkel cell carcinoma, an aggressive form of skin cancer with a high (>30%) mortality rate. The virus has a high incidence in patients with immunosuppressed conditions, such as AIDS or leukemia, or following organ transplantation. Here, we report the complete genomic sequence of MCPyV identified from a blood sample from a patient with acute myeloid leukemia.
Handball load and shoulder injury rate: a 31-week cohort study of 679 elite youth handball players
Authors: Møller M , Nielsen R O , Attermann J , Wedderkopp N , Lind M , Sørensen H , Myklebust G 
Published: January 2017

BackgroundKnowledge of injury patterns, an essential step towards injury prevention, is lacking in youth handball.AimTo investigate if an increase in handball load is associated with increased shoulder injury rates compared with a minor increase or decrease, and if an association is influenced by scapular control, isometric shoulder strength or glenohumeral range of motion (ROM).Methods679 players (14–18 years) provided weekly reports on shoulder injury and handball load (training and competition hours) over 31 weeks using the SMS, phone and medical examination system. Handball load in a given week was categorised into (1) <20% increase or decrease (reference), (2) increase between 20% and 60% and (3) increase >60% relative to the weekly average amount of handball load the preceding 4 weeks. Assessment of shoulder isometric rotational and abduction strength, ROM and scapular control was performed at baseline and midseason.ResultsAn increase in handball load by >60% was associated with greater shoulder injury rate (HR 1.91; 95% CI 1.00 to 3.70, p=0.05) compared with the reference group. The effect of an increase in handball load between 20% and 60% was exacerbated among players with reduced external rotational strength (HR 4.0; 95% CI 1.1 to 15.2, p=0.04) or scapular dyskinesis (HR 4.8; 95% CI 1.3 to 18.3, p=0.02). Reduced external rotational strength exacerbated the effect of an increase above 60% (HR 4.2; 95% CI 1.4 to 12.8, p=0.01).ConclusionsA large increase in weekly handball load increases the shoulder injury rate in elite youth handball players; particularly, in the presence of reduced external rotational strength or scapular dyskinesis.
Protocol of a feasibility study for cognitive assessment of an ageing cohort within the Southeast Asia Community Observatory (SEACO), Malaysia
Authors: Mohan Devi , Stephan Blossom C M , Allotey Pascale , Jagger Carol , Pearce Mark , Siervo Mario , Reidpath Daniel D 
Published: January 2017

IntroductionThere is a growing proportion of population aged 65 years and older in low-income and middle-income countries. In Malaysia, this proportion is predicted to increase from 5.1% in 2010 to more than 15.4% by 2050. Cognitive ageing and dementia are global health priorities. However, risk factors and disease associations in a multiethnic, middle-income country like Malaysia may not be consistent with those reported in other world regions. Knowing the burden of cognitive impairment and its risk factors in Malaysia is necessary for the development of management strategies and would provide valuable information for other transitional economies.Methods and analysisThis is a community-based feasibility study focused on the assessment of cognition, embedded in the longitudinal study of health and demographic surveillance site of the South East Asia Community Observatory (SEACO), in Malaysia. In total, 200 adults aged ≥50 years are selected for an in-depth health and cognitive assessment including the Mini Mental State Examination, the Montreal Cognitive Assessment, blood pressure, anthropometry, gait speed, hand grip strength, Depression Anxiety Stress Score and dried blood spots.Discussion and conclusionsThe results will inform the feasibility, response rates and operational challenges for establishing an ageing study focused on cognitive function in similar middle-income country settings. Knowing the burden of cognitive impairment and dementia and risk factors for disease will inform local health priorities and management, and place these within the context of increasing life expectancy.Ethics and disseminationThe study protocol is approved by the Monash University Human Research Ethics Committee. Informed consent is obtained from all the participants. The project's analysed data and findings will be made available through publications and conference presentations and a data sharing archive. Reports on key findings will be made available as community briefs on the SEACO website.
Patient understanding of liver cirrhosis and improvement using multimedia education
Authors: Goldsworthy Matthew A , Fateen Waleed , Thygesen Helene , Aldersley Mark A , Rowe Ian A , Jones Rebecca L 
Published: January 2017

ObjectiveFor patients to engage with the long-term management of liver cirrhosis, sufficient understanding of their condition is essential. The aim of this study was to assess baseline patient knowledge and to test whether a condition-specific multimedia screencast could improve this.DesignService quality improvement study.SettingA UK tertiary liver centre. Patients were recruited during 12 general hepatology outpatient clinics.PatientsFifty-two patients with liver cirrhosis were included. Sixty-two per cent were male; their median age was 56 years and their median clinic attendance period was 3 years.InterventionsParticipants completed a baseline questionnaire assessing their knowledge of the management and complications of cirrhosis. They then watched a tailored screencast discussing this condition, which had been developed by expert hepatologists in collaboration with patient representatives. Knowledge was reassessed using a new copy of the original questionnaire after an interval of at least one month.Main outcome measuresPatient scores on knowledge questionnaires at baseline and follow-up.ResultsFifty-two patients achieved a median score of 25.0% before viewing the screencast. Thirty-five patients then completed a follow-up questionnaire after an interval period. The median questionnaire score in this group improved from 25.0% to 66.7%; an increase of 41.7% compared with baseline (p<0.001).ConclusionsDespite regular review at a specialist clinic, participants had poor baseline knowledge of liver cirrhosis. Delivering information by screencast led to a significant improvement. We therefore present an effective way to empower patients with accurate, up-to-date and retainable information that can easily be translated to many other conditions.
Galectin-1 expression is associated with tumour immunity and prognosis in gingival squamous cell carcinoma
Authors: Noda Yuri , Kishino Mitsunobu , Sato Sunao , Hirose Katsutoshi , Sakai Manabu , Fukuda Yasuo , Murakami Shumei , Toyosawa Satoru 
Published: January 2017

AimsGalectin-1 (Gal-1) is a β-galactoside-binding protein that overexpresses in cancer and plays pivotal roles in tumour progression. Gal-1 regulates angiogenesis and invasiveness, and suppresses tumour immunity by inducing T cell apoptosis. Several studies have examined the relationship between Gal-1 and tumour immunosuppression in vivo, but they have not examined the clinicopathological relationship between Gal-1 expression and apoptotic T cell number in human tissue. In this study, we investigated the association between Gal-1 expression and apoptotic T cells of gingival squamous cell carcinoma (GSCC), as well as other clinicopathological factors.MethodsImmunohistochemical investigation of 80 GSCC specimens using anti-Gal-1, anti-CD3, anti-CD4, anti-CD8, anti-CD34, antipodoplanin and anticleaved caspase-3 (CC-3) antibodies was performed. Relative expression levels of CD3 and CC-3, as well as CD8 and CC-3 were assessed simultaneously by double immunostaining. Gal-1 expression and T cell apoptosis were evaluated in 6 high-power fields (3 in the tumour and 3 in the stroma).ResultsGal-1 expression in GSCC was significantly correlated with T cell infiltration (p=0.036), and apoptosis of CD3+ and CD8+ T cells (p<0.001). Moreover, Gal-1 expression was significantly correlated with lymph node metastasis (p=0.021), histological differentiation (p<0.001) and overall survival rate (p=0.021).ConclusionsThese findings suggest that Gal-1 plays an important role in immune escape of GSCC cells, and Gal-1 expression level may be a useful clinicopathological prognostic marker for GSCC.
Reduced prosthetic stiffness lowers the metabolic cost of running for athletes with bilateral transtibial amputations
Authors: Beck Owen N. , Taboga Paolo , Grabowski Alena M. 
Published: January 2017

Inspired by the springlike action of biological legs, running-specific prostheses are designed to enable athletes with lower-limb amputations to run. However, manufacturer’s recommendations for prosthetic stiffness and height may not optimize running performance. Therefore, we investigated the effects of using different prosthetic configurations on the metabolic cost and biomechanics of running. Five athletes with bilateral transtibial amputations each performed 15 trials on a force-measuring treadmill at 2.5 or 3.0 m/s. Athletes ran using each of 3 different prosthetic models (Freedom Innovations Catapult FX6, Össur Flex-Run, and Ottobock 1E90 Sprinter) with 5 combinations of stiffness categories (manufacturer’s recommended and ± 1) and heights (International Paralympic Committee’s maximum competition height and ± 2 cm) while we measured metabolic rates and ground reaction forces. Overall, prosthetic stiffness [fixed effect (β) = 0.036; P = 0.008] but not height ( P ≥ 0.089) affected the net metabolic cost of transport; less stiff prostheses reduced metabolic cost. While controlling for prosthetic stiffness (in kilonewtons per meter), using the Flex-Run (β = −0.139; P = 0.044) and 1E90 Sprinter prostheses (β = −0.176; P = 0.009) reduced net metabolic costs by 4.3–4.9% compared with using the Catapult prostheses. The metabolic cost of running improved when athletes used prosthetic configurations that decreased peak horizontal braking ground reaction forces (β = 2.786; P = 0.001), stride frequencies (β = 0.911; P < 0.001), and leg stiffness values (β = 0.053; P = 0.009). Remarkably, athletes did not maintain overall leg stiffness across prosthetic stiffness conditions. Rather, the in-series prosthetic stiffness governed overall leg stiffness. The metabolic cost of running in athletes with bilateral transtibial amputations is influenced by prosthetic model and stiffness but not height.NEW & NOTEWORTHY We measured the metabolic rates and biomechanics of five athletes with bilateral transtibial amputations while running with different prosthetic configurations. The metabolic cost of running for these athletes is minimized by using an optimal prosthetic model and reducing prosthetic stiffness. The metabolic cost of running was independent of prosthetic height, suggesting that longer legs are not advantageous for distance running. Moreover, the in-series prosthetic stiffness governs the leg stiffness of athletes with bilateral leg amputations.
Mapping of Flooded Areas in the Kudus District
Authors: Fiati Rina , Latubessy Anastasya 
Published: January 2017

<p>Flood is still an annual problem in the Kudus District. Based on the survey and interview with Regional Disaster Management Agency (BPBD – Badan Penanggulangan Bencana Daerah) data showed that in the Kudus District there are still many flood-prone areas. They also said that, there are six parameter that can be used to identify potential flood area such as: extensive inundation (km2, ha), depth or height of flood waters (meters), the flow velocity (m/s,km/h), the material washed away by flood flow (rocks, boulders, trees, and other solid objects), concentrations of water or silt thickness (meters, centimeters), and duration of inundation (hours, days, months). Therefor this research use six parameters are then analyzed and used as a benchmark model to identify flood-prone areas by using the production rule method, and as the material in constructing and designing flood-prone area identification systems based on expert system. Thus this research resulted a system to assist the identification of flood prone areas in the Kudus District by using expert system and geographic information system (GIS).</p>