bluuebunny/crossref_metadata_2025_split huggingface dataset:
The SARS‐unique domain (SUD) of SARS‐CoV‐2 nsp3 protein inhibits the antiviral immune responses through the NF‐κB pathway
Authors: Xie Siyi , Song Zheng , Chen Ran , Zhang Xu , Wu Shuangxin , Chen Jingliang , Huang Peiming , Liu Hanxin , Yu Kaixin , Zhang Yixin , Tan Siyu , Liu Jun , Ma Xiancai , Zhang Hui , He Xin , Pan Ting 
Published: October 2024

AbstractNuclear factor κB (NF‐κB) plays a crucial role in various cellular processes, including inflammatory and immune responses. Its activation is tightly regulated by the IKK (IκB kinase) complex. Upon severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, the virus is initially recognized by the innate immune system and typically activates the NF‐κB pathway, leading to a severe inflammatory response. However, the influence of viral proteins upon pro‐inflammatory pathway is complicated. Here, we demonstrated that the viral protein nsp3 of SARS‐CoV‐2 exhibits an unusual function, which attenuated the NF‐κB‐mediated inflammatory response against SARS‐CoV‐2 infection in a unique manner. nsp3 interacted with the essential NF‐κB modulator NEMO/IKKγ and promoted its polyubiquitylation via the E3 ubiquitin ligase CBL (Cbl Proto‐Oncogene). Consequently, polyubiquitylated NEMO undergoes proteasome‐dependent degradation, which disrupts NF‐κB activation. Moreover, we found that the SARS unique domain (SUD) in nsp3 of SARS‐CoV‐2 is essential for inducing NEMO degradation, whereas this function is absent in SUD of SARS‐CoV. The reduced activation of pro‐inflammatory response at an early stage could mask the host immune response and faciliate excessive viral replication. Conversely, this finding may partially explain why SARS‐CoV‐2 causes a less inflammatory reaction than SARS‐CoV, resulting in more mild or moderate COVID‐19 cases and greater transmissibility. Given that NEMO is important for NF‐κB activation, we propose that inhibiting polyubiquitylation and degradation of NEMO upon SARS‐CoV‐2 infection is a novel strategy to modulate the host inflammatory response.
Predictability of indicators in local activation time mapping of ablation success for premature ventricular contractions
Authors: Nagase Takahiko , Kikuchi Takafumi , Akai Shun , Himeno Masafumi , Ooyama Ryo , Yoshida Yoshinori , Yoshino Chiyo , Nishida Takafumi , Tanaka Takahisa , Ishino Mitsunori , Kato Ryuichi , Kuwada Masao 
Published: October 2024

AbstractIntroductionDifferences in predictability of ablation success for premature ventricular contractions (PVCs) between earliest isochronal map area (EIA), local activation time (LAT) differences on unipolar and bipolar electrograms (⊿LATBi‐Uni), LAT prematurity on bipolar electrograms (LATBi), and unipolar morphology of QS or Q pattern remain unclear. We verified multiple statistical predictabilities of those indicators of ablation success on mapped cardiac surface.MethodsThirty‐five patients with multiple PVCs underwent catheter ablation after LAT mapping using multipolar mapping catheters with unipolar‐based annotation. Patients were divided into success and failure groups based on ablation success on mapped cardiac surfaces. Discrimination ability, reclassification table, calibration plots, and decision curve analysis of 10 ms EIA (EIA10ms), ⊿LATBi‐Uni, and LATBi were validated. Unipolar morphology was compared between success and failure groups.ResultsRight ventricular outflow tract, aortic cusp, and left ventricle were mapped in 17, 10, and 8 patients, respectively. In 14/35 (40%) patients, successful ablation was performed on mapped cardiac surfaces. Area under the curve of receiver‐operating characteristic curve of EIA10ms, ⊿LATBi‐Uni, and LATBi were 0.874, 0.801, and 0.650, respectively (EIA10ms vs. LATBi, p =.014; ⊿LATBi‐Uni vs. LATBi, p =.278; EIA10ms vs. ⊿LATBi‐Uni, p =.464). EIA10ms and ⊿LATBi‐Uni demonstrated better predictability, calibration, and clinical utility on reclassification table, calibration plots, and decision curve analysis than LATBi. Unipolar morphology of QS or Q pattern did not correlate with ablation success (p =.518).ConclusionEIA10ms and ⊿LATBi‐Uni more accurately predict ablation success for PVCs on mapped cardiac surfaces than LATBi and unipolar morphology.
Sporosarcina hypophthalmichthys sp. nov. Isolated From Gastrointestinal Tract of Fish Hypophthalmichthys molitrix (Valenciennes, 1844)
Authors: Bharti Meghali , Sharma Monika , Choksket Stanzin , Khurana Himani , Siwach Sneha , Modeel Sonakshi , Korpole Suresh , Negi Ram Krishan 
Published: October 2024

ABSTRACTA rod‐shaped, motile, Gram‐stain‐positive bacterial strain RKN2T, was isolated from gut of silver carp (Hypophthalmichthys molitrix) residing in Gobindsagar reservoir, Himachal Pradesh, India. Having the greatest sequence similarity to Sporosarcina koreensis F73T (98.51%), Sporosarcina luteola Y1T (98.4%) and Sporosarcina aquimarina SW28T (98.36%), the 16S rRNA gene phylogeny confirmed the belonging of strain RKN2T to genus Sporosarcina. Digital DNA‐DNA hybridization values were 21.7%, 20.6%, and 19.2%, and average nucleotide identity values were 76.42%, 80.16%, 76.51%, of strain RKN2T with Sporosarcina koreensis F73T, Sporosarcina luteola Y1T, and Sporosarcina aquimarina SW28T, respectively. The genomic analysis of strain RKN2T showed various biological properties including nitrate reduction, genes responsible for carbohydrate‐active enzymes production, antimicrobial compounds, as well as potential metabolism of aromatic compounds and heavy metals. G+C composition of RKN2T genome was 52.7%. This strain can grow in temperatures between 10°C and 40°C (optimum, 28°C–30°C), NaCl concentrations up to 6.0% (w/v), and 6.0–8.0 (optimum, 6.5–7.5) pH range. MK‐7 was the dominant respiratory quinone, A‐4 type cell wall peptidoglycan was present with anteiso‐C15:0, iso‐C15: 0, and anteiso‐C17:0 being the major fatty acids and Lys‐Glu being main amino acids. Diphosphatidylglycerol, phosphatidylglycerol, and phosphatidylethanolamine were the strain RKN2T's three main polar lipids. The strain is a novel species under genus Sporosarcina based on polyphasic approach and the name Sporosarcina hypophthalmichthys sp. nov. is given for strain RKN2T. RKN2T is a type strain (= MCC 4365T = JCM34522T = CCM9112T).
Attributions of Rainfall Anomalies to Weather Systems and Their Spatial and Temporal Variabilities: A Case Study of Victoria in Southeast Australia
Authors: Fu Guobin , Chiew Francis H. S. , Post David A. , Pepler Acacia , Rudeva Irina 
Published: October 2024

ABSTRACTAttributions of rainfall anomalies to weather systems and their spatio‐temporal variability in Victoria, southeast Australia are investigated with a multimethod weather type dataset and two popularly used gridded daily rainfall datasets for the period 1979–2015. The rainfall anomalies before, during and after the Millennium Drought (1997–2009) are compared to quantify the temporal variability of rainfall responses to weather type changes. The results show: (1) Three weather systems (Front, Cyclone and Thunderstorm) and their combinations contribute 89% of total rainfall; (2) Contributions of weather types to rainfall vary from month to month with winter season rainfall coming from more diverse weather types than summer rainfall; (3) The contributions of weather types to rainfall in three periods show temporal variabilities and there is a clear shift of contribution pattern after the Millennium Drought, such as front‐thunderstorm (FT) is now the largest contributor to rainfall compared with cyclone‐frontal‐thunderstorm (CFT) before and during the Millennium Drought; (4) A seasonal shift in the post‐drought period is found with higher rainfall in February and March and lower rainfall in September and October. The increased rainfall in February mainly results from Front–Thunderstorm (FT) and Thunderstorm‐only (TO), while rainfall declines in September from all weather types; (5) Several rainfall characteristics that are important for streamflow generation, such as rainfall intensity, probability of rainfall occurrence, number of rainfall days and the maximum daily rainfall, do depend on the weather types; (6) The results are similar with different rainfall datasets, but differences do exist, especially at the local scale. The conclusions of this study are drawn from an Australian case study but have implications for other regions to investigate the attributions of rainfall characteristic changes to weather systems.
Investigating the Role of Migration on Household Wellbeing: A Study in an Emerging Market
Authors: Swain Suchi Smita , Paul Ujjwal Kanti , Kumar Satish , Das Gurudas 
Published: October 2024

ABSTRACTThis study aims to investigate the impact of internal migration on household wellbeing, measured using a multidimensional wellbeing index (MWI). Utilizing the Alkire–Foster methodology, we conceptualize MWI to encompass the following five broad dimensions: education, health, income and employment, standard of living, and inclusion. The study is based on household‐level primary data collected from the Indian state of Jharkhand using a multistage stratified sampling method. Data were analyzed using probit regression with MWI as a dependent variable. Our findings suggest that (i) internal migration has a positive association with households' wellbeing and (ii) the inflow of remittances significantly contributes to increasing the total household income of migrant families, which positively impacts household wellbeing.
Pathophysiology of Peritoneal Metastasis
Authors: Demuytere Jesse , Ernst Sam , Ceelen Wim 
Published: October 2024

ABSTRACTPeritoneal metastasis is the result of a complex, stepwise process that involves multiple, spatially and temporally distinct interactions between the primary cancer, disseminated cancer cells or clusters, and the mesothelial lining of the peritoneal cavity and intraperitoneal organs. The biology of peritoneal metastasis, long a neglected field of research, is now increasingly being unraveled. Here, we provide an update on the mechanisms that drive the journey that eventually leads to widespread peritoneal metastatic disease.
Cultural Routes Through the Perspective of Sustainable Mobility: A Critical Literature Review
Authors: Zouridaki M. , Apostolakis A. , Kourgiantakis M. 
Published: October 2024

ABSTRACTSustainable mobility strategies in the locale could facilitate cultural routes' social, economic, cultural, and environmental mandates. The purpose of this article is to explore the beneficial practices of sustainable mobility on cultural routes through a systematic literature review. The ultimate objective is to summon the sustainable mobility strategies implemented on cultural routes that could positively affect the economic, social, environmental, and cultural environments of a destination. A systematic literature review was initiated through the protocol of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses methodology. The meta‐synthesis approach resulted in identifying five sustainable mobility policy recommendations suitable for cultural route development. Slow mobility practices, drive tourism, mobility infrastructures along cultural routes, accessibility into cultural routes, and urban mobility are fundamental for the creation of an efficient sustainable mobility plan to support cultural routes and achieve a sustainable tourism future for regions.
Diffusion‐Weighted MRI Over Standard MRI for Differential Diagnosis between Mucopyocele and Mucoceles
Authors: Adewole Vanessa , Boubaker Fatma , Hossu Gabriela , Nguyen Duc T. , Blum Alain , Gondim Teixeira Pedro A. , Rumeau Cécile , Gillet Romain 
Published: October 2024

Objective(s)To determine the accuracy of conventional and diffusion‐weighted (DWI) MRI for the differential diagnosis between mucopyocele and mucocele using surgical diagnosis as a reference.MethodsThis retrospective study included patients referred to our institution between March 2017 and February 2024 for paranasal sinus MRI to characterize an expansile non‐enhanced sinus filling on CT. The T1 and T2 signal intensities were recorded, as well as the presence of restriction diffusion, of the penumbra sign, the double rim sign, and the presence of parietal micro‐abscesses. Quantitative apparent diffusion coefficient values were also recorded.ResultsThe study included 74 patients aged 18 to 88 years (mean age: 60.4 ± 17.7 years). Of these, 43 had a mucopyocele and 31 had a mucocele. The T1 high signal intensity was different amongst groups as an hypersignal was present in 35.5% of mucoceles and only 4.7% of mucopyoceles (p = 0.02). The T2 signal did not differ between the two groups (p = 0.59). The double rim sign and the presence of parietal micro‐abscesses demonstrated 96.8% and 100% specificities, respectively, but were predominantly located in the maxillary sinus. The penumbra sign exhibited a sensitivity of 60.5% and a specificity of 67.7%. All mucopyoceles exhibited a diffusion restriction with an apparent diffusion coefficient of less than 0.78 × 10–3 mm2/s.ConclusionDWI is the most useful MRI tool for the accurate differential diagnosis between mucopyocele and mucocele in non‐enhanced sinus fillings.Level of Evidence3 (case–control study) Laryngoscope, 135:1008–1014, 2025
Diagnostic Accuracy of Beta‐2 Transferrin Gel Electrophoresis for Detecting Cerebrospinal Fluid Rhinorrhea
Authors: Eide Jacob G. , Mason William , Mackie Hussein , Cook Bernard , Ray Amrita , Asmaro Karam , Robin Adam , Rock Jack , Craig John R. 
Published: October 2024

ObjectiveUnilateral thin clear rhinorrhea (UTCR) may represent a variety of pathologies including cerebrospinal fluid (CSF) rhinorrhea. Beta‐2 transferrin (B2Tf) gel electrophoresis (GE) has become the preferred testing modality due to reportedly high sensitivity (87%–100%) and specificity (71%–100%). However, there have been relatively few studies assessing its diagnostic accuracy. The purpose of this single‐institution study was to determine the accuracy of B2Tf GE in detecting CSF rhinorrhea.MethodsA single‐center retrospective review was conducted from 2016 and 2024 for all patients who presented with UTCR and underwent B2Tf GE. Institutional review board approval was obtained. The gold standard for diagnostic confirmation of true and false positives (TP, FP) as well as false negatives (FN) was endoscopic exploration. The gold standard for true negative (TN) was response to medical therapy.ResultsA total of 105 patients underwent 149 B2Tf GE tests. 40 (38.1%) patients were diagnosed with CSF rhinorrhea. Of the 149 B2‐Tf GE tests, there were 51 TPs, 72 TNs, 20 FPs, and 6 FNs yielding 89.5% sensitivity, 78.3% specificity, 71.8% positive predictive value, and 92.3% negative predictive value, respectively. Of the false results the most common causes for error were purulent sinusitis (n = 6, 23.1%), possible mucous contamination from nose‐blowing during collection (n = 3, 11.5%), patient collection error (n = 3, 11.5%), and blood contamination (n = 1, 3.8%).ConclusionAlthough these single‐institutional data demonstrate test accuracy within ranges previously reported in the literature, they also demonstrate diagnostic limitations. Future studies should explore reasons for erroneous B2Tf GE results and how these may change clinical decision‐making.Level of EvidenceIV Laryngoscope, 2024
Organic‐Inorganic Dual‐Network Composite Separators for Lithium Metal Batteries
Authors: Liu Zetong , Li Pingan , Hu Kangjia , Sun Hao , Li Rongxing , Yang Shanshan , Hu Xianluo 
Published: October 2024

AbstractThe suboptimal ionic conductivity of commercial polyolefin separators exacerbates uncontrolled lithium dendrite formation, deteriorating lithium metal battery performance and posing safety hazards. To address this challenge, a novel organic‐inorganic composite separator designed is prepared to enhance ion transport and effectively suppress dendrite growth. This separator features a thermally stable, highly porous poly(m‐phenylene isophthalamide) (PMIA) electrospun membrane, coated with ultralong hydroxyapatite (HAP) nanowires that promote “ion flow redistribution.” The synergistic effects of the nitrogen atoms in PMIA and the hydroxyl groups in HAP hinder anion transport while facilitating efficient Li+ conduction. Meanwhile, the optimized unilateral pore structure ensures uniform ion transport. These results show that the 19 µm‐thick HAP/PMIA composite separator achieves remarkable ionic conductivity (0.68 mS cm−1) and a high lithium‐ion transference number (0.51). Lithium symmetric cells using HAP/PMIA separators exhibit a lifespan exceeding 1000 h with low polarization, significantly outperforming commercial polypropylene separators. Furthermore, this separator enables LiFePO4||Li cells to achieve an enhanced retention of 97.3% after 200 cycles at 1 C and demonstrates impressive rate capability with a discharge capacity of 72.7 mAh g−1 at 15 C.
Genomic Correlation, Shared Loci, and Causal Relationship Between Bullous Pemphigoid and Atopic Dermatitis: A Large‐Scale Genome‐Wide Cross‐Trait Analysis
Authors: Wang Qing , Wang Xuehua , Zhuang Qizhen , Wu Yuan , Zhang Junhong , Lu Yue , Wu Jingjing , Liu Juanjuan , Hu Xiangyu , Han Ling 
Published: October 2024

ABSTRACTBackgroundBullous pemphigoid (BP) and atopic dermatitis (AD) are currently thought to be tightly related, yet studies of the mechanisms of co‐morbidities are lacking.MethodsWe obtained GWAS data for BP (N = 376,274) and AD (N = 796,661) from the Finnish Genetic Research Program dataset and the UK Biobank, separately. Then, the following four analyses were performed: (1) cross‐trait linkage disequilibrium score regression (LDSC) to assess the genetic correlation between BP and AD, (2) cross‐phenotype association analysis (CPASSOC) to identify multiple effector loci shared by BP and AD, (3) transcriptome‐wide association study (TWAS) to determine whether their cross‐organizational expression patterns share genes with a common biological mechanism of relevance, and (4) bidirectional Mendelian randomization (MR) analysis to assess bidirectional causal effects of BP and AD.ResultsWe found a positive genetic association between BP and AD (rg = 0.5476, p = 0.0495) as well as identified four pleiotropic loci and 59 common genes affecting BP and AD. Bidirectional MR analysis suggested that BP promotes the risk of AD.ConclusionsWe revealed a genetic link between BP and AD, which is associated with biological pleiotropy and causality. Awareness of the association between BP and AD helps dermatologists manage patients with these illnesses.
Broadband low radar cross section frequency selective surface radome based on phase cancellation and spatial filtering
Authors: Sun Lili , Guo Meng , Tong Yuchen , Hu Ziying , Huang Ping , Zhang Xingliang , Wang Wei 
Published: October 2024

AbstractThis letter introduces a novel design approach for broadband radar cross section (RCS) reduction of frequency selective surface (FSS) radomes. The approach integrates the principles of phase cancellation and spatial filtering together through a hybrid design method. The phase cancellation is obtained through the checkerboard arrangement of units, and the spatial filtering characteristics is achieved by the slot etched on the ground plane. Experimental and simulation results demonstrate that etching slots on the ground plane maintains broadband in‐phase reflection and bandpass characteristics, thereby extending the bandwidth of RCS reduction through a combination of two operation bands. Theoretical analysis of the working mechanism is also provided using equivalent circuit models. In comparison to the conventional radomes, the proposed FSS radome achieves significant bandwidth improvement for RCS reduction, indicating that it has promising prospects in future low‐RCS radome applications.
‘I Do Not Want to Share My Pain With Anyone’—Coping With the Invisible Burden. A Qualitative Description of the Lived Experiences of Individuals With Rotator Cuff Related Shoulder Pain in an Indian Setting
Authors: Vishal Kavitha , Arumugam Ashokan , Sole Gisela , Shetty Greeshma , Pandey Vivek , Maiya G. Arun 
Published: October 2024

ABSTRACTBackgroundRotator cuff related shoulder pain (RCRSP) significantly impacts the physical, and psychosocial well‐being of an individual. While studies of lived experiences with shoulder pain were conducted in Western (developed countries) contexts, understanding such experiences in low‐to middle‐income countries such as India remains limited.ObjectiveThis study explores and describes the lived experiences of individuals with RCRSP in Indian settings.MethodsA phenomenological approach explored the lived experience of individuals with RCRSP in South India. Ten participants with RCRSP (7 men and 3 women) with mean duration of symptoms ranging between 3 and 24 months were interviewed individually using a semi‐structured guide with inductive thematic analysis. Participants also completed the Disabilities of the Shoulder Arm and Hand (DASH) questionnaire for upper limb function. Interviews were audio recorded and transcribed verbatim.ResultsThree themes that emerged from the interviews were ‘The multidimensional burden of RCRSP’, ‘Navigating the treatment journey between trust and uncertainties’, and ‘Pathway of healing: Coping with the invisible burden’. Shoulder pain significantly impacted activities, family, and volunteering roles. The majority of the suffering and expression of pain were hidden and influenced by cultural and societal norms. There was a strong belief in the body's ability to heal and acceptance of Eastern and Western treatment approaches.ConclusionThe findings highlight the need for a holistic management strategy that effectively addresses physical impairments, psychosocial support, and cultural beliefs to manage RCRSP in such settings.
High performance Calcium Copper Titanate/Polyimide dielectrics composites enabled through colloidal stabilization
Authors: Lamm Meghan E. , Armstrong Beth L. , Chowdhury Shajjad , Lamm Benjamin W. , Aytug Tolga , Li Kai , Duckworth Robert , Haynes J. A. 
Published: October 2024

AbstractTransition to electrified transportation demands advanced power electronic components with the capability to improve range, reliability, and cost of ownership to accelerate mass market adoption. Thus, improvement in the current designs, manufacturing processes, materials, and components capable of providing reliable and efficient operation at higher temperatures play important roles in meeting future needs. To address these challenges, this article focuses on novel dielectric materials designed to reduce the volume of the most important and bulky component of a power electronic system, a capacitor. A new composite dielectric material was developed by integrating the positive attributes of both polymer and ceramic capacitors to overcome the challenges of state‐of‐the‐art dielectric materials. The developed composite properties have been evaluated and showed promising results, achieving a dielectric constant of 250 at 100 Hz, 25°C, unseen in current literature. Additionally, these materials can function at high temperatures (>150°C) with good breakdown strength, providing promising working conditions for capacitors, especially in electric vehicle applications.Highlights
Dielectric composites were synthesized from calcium copper titanate and polyimide.
A dispersive agent showed promise in achieving a homogenous, stable mixture.
Composites were prepared using tape casting.
A dielectric constant of 250 was achieved at 100 Hz, 25°C.
At elevated temperature, the dielectric constant increased to over 700%.