bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated Mitochondrial DNA Copy Number in Peripheral Blood and Tissue Predict the Opposite Outcome of Cancer: A Meta-Analysis
Authors: Chen Nan , Wen Shu , Sun Xiaoru , Fang Qian , Huang Lin , Liu Shuai , Li Wanling , Qiu Meng 
Published: November 2016

AbstractPrevious studies have suggested that mitochondrial DNA (mtDNA) copy number was associated with cancer risk. However, no solid conclusion revealed the potential predictive value of mtDNA copy number for cancer prognosis. The present meta-analysis was performed to clarify the problem. Hence, we performed a systematic search in PubMed, EmBase, Web of Science databases independently and a total of eighteen studies comprising 3961 cases satisfied the criteria and finally enrolled. Our results didn’t show the association between them but significant heterogeneity in overall analysis (OS: HR = 0.923, 95% CI: 0.653–1.306, p = 0.652; DFS: HR = 0.997, 95% CI: 0.599–1.659, p = 0.99). However, subgroup analysis stratified by sample came to the opposite conclusion. High level mitochondrial DNA copy number in peripheral blood predicted a poor cancer prognosis (OS: HR = 1.624, 95% CI: 1.211–2.177, p = 0.001; DFS: HR = 1.582, 95% CI: 1.026–2.439, p = 0.038) while patients with high level mitochondrial DNA copy number in tumor tissue exhibited better outcomes (OS: HR = 0.604 95% CI: 0.406–0.899, p = 0.013; DFS: HR = 0.593, 95% CI: 0.411–0.857, p = 0.005). These findings were further proved in detailed analyses in blood or tissue subgroup. In conclusion, our study suggested the elevated mtDNA copy number in peripheral blood predicted a poor cancer prognosis while the better outcome was presented among patients with elevated mtDNA copy number in tumor tissue.
Non-High-Density Lipoprotein Cholesterol Levels on the Risk of Asymptomatic Intracranial Arterial Stenosis: A Result from the APAC Study
Authors: Wu Jianwei , Wang Anxin , Li Xin , Wu Shouling , Zhao Xingquan 
Published: November 2016

AbstractIntracranial arterial stenosis (ICAS) is an important cause of ischemic stroke and transient ischemic attack (TIA), and the correlation between the plasma non-high density cholesterol (non-HDLC) levels and ICAS, especially asymptomatic ICAS (AICAS) is not clear. The Asymptomatic Polyvascular Abnormalities Community(APAC) study is a community-based, prospective, long-term follow-up observational study. 3387 participants were enrolled in this study. The diagnosis of AICAS was made by transcranial Doppler ultrasonography. The participants were then divided into 3 groups based on their non-HDLC levels. The cox regression was used to analyze the correlation between the non-HDLC level and the incidence of AICAS.9.98% of the participants were diagnosed with AICAS during 2 years following up. Multivariate analysis showed that non-HDL-C is an independent indicator for the incidence of AICAS (HR = 1.22, 95%CI: 1.06–1.40), The incidence of AICAS gradually increase with the increasing non-HDLC level. Compared with subgroup(non-HDLC < 3.4 mmol/l), incidence of AICAS was significantly higher in the subgroups(non-HDLC 3.4–4.1 mmol/l and non-HDLC ≥ 4.1 mmol/l) after adjustment for the confounding factors (HR = 1.32, 95%CI:1.02–1.73; HR = 1.46, 95%CI: 1.10–1.94, respectively). In conclusions, our findings suggest that elevated non-HDLC levels a significant risk factor for the development of AICAS in the APAC study.
Tet1-dependent epigenetic modification of BDNF expression in dorsal horn neurons mediates neuropathic pain in rats
Authors: Hsieh Ming-Chun , Lai Cheng-Yuan , Ho Yu-Cheng , Wang Hsueh-Hsiao , Cheng Jen-Kun , Chau Yat-Pang , Peng Hsien-Yu 
Published: November 2016

AbstractTen-eleven translocation methylcytosine dioxygenase 1 (Tet1) mediates the conversion of 5-methylcytosine (5 mC) to 5-hydroxymethylcytosine (5 hmC), hence promoting DNA demethylation. Although recent studies have linked the DNA demethylation of specific genes to pain hypersensitivity, the role of spinal Tet1-dependent DNA demethylation in nociception hypersensitivity development remains elusive. Here, we report correlated with behavioral allodynia, spinal nerve ligation (SNL) upregulated Tet1 expression in dorsal horn neurons that hydroxylate 5 mC to 5 hmC at CpG dinucleotides in the bdnf promoter to promote spinal BDNF expression at day 7 after operation. Focal knockdown of spinal Tet1 expression decreased Tet1 binding and 5 hmC enrichment, further increased 5 mC enrichment at CpG sites in the bdnf promoter and decreased spinal BDNF expression accompanied by the alleviation of the developed allodynia. Moreover, at day 7 after operation, SNL-enhanced Tet1 expression also inhibited the binding of DNA methyltransferases (DNMTs, i.e., DNMT1, DNMT3a, and DNMT3b) to the bdnf promoter, a requirement for transcriptional silencing by catalysing 5-cytosine (5C) to 5 mC. Together, these data suggest at CpG sites of the bdnf promoter, SNL-enhanced Tet1 expression promotes DNA demethylation both by converting 5 mC to 5 hmC and inhibiting DNMT binding to regulate spinal BDNF expression, hence contributing to behavioral allodynia development.
The Modification of Tet1 in Male Germline Stem Cells and Interact with PCNA, HDAC1 to promote their Self-renewal and Proliferation
Authors: Zheng Liming , Zhai Yuanxin , Li Na , Ma Fanglin , Zhu Haijing , Du Xiaomin , Li Guangpeng , Hua Jinlian 
Published: November 2016

AbstractEpigenetic modification plays key roles in spermatogenesis, especially DNA methylation dynamic is important in sustaining normal spermatogenesis. Ten-eleven translocation 1 (Tet1) is not only a key demethylase, which works in specific gene regions, but also crosstalks with partners to regulate epigenetic progress as protein complexes. Dairy goat is an important livestock in China, while the unstable culture system in vitro inhibits optimization of new dairy goat species. The study of epigenetic modification in male germline stem cells (mGSCs) is beneficial to the optimization of adult stem cell culture system in vitro, and the improvement of sperm quality and breeding of selected livestock. In our study, we not only analyzed the morphology, gene expression, DNA methylation and histone methylation dynamic in mouse Tet1 (mTet1) modified mGSCs, we also analyzed the stemness ability by in vivo transplantation and explored the functional mechanism of Tet1 in dairy goat mGSCs. The results showed mTet1 modified mGSCs had better self-renewal and proliferation ability than wild-type mGSCs, mTet1 could also up-regulate JMJD3 to decrease H3K27me3, which also showed to suppress the MEK-ERK pathway. Furthermore, Co-IP analysis demonstrated that TET1 interact with PCNA and HDAC1 by forming protein complexes to comprehensively regulate dairy goat mGSCs and spermatogenesis.
miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer
Authors: Hong Yeting , Liang Hongwei , Uzair-ur-Rehman  , Wang Yanbo , Zhang Weijie , Zhou Yong , Chen Song’an , Yu Mengchao , Cui Sufang , Liu Minghui , Wang Nan , Ye Chao , Zhao Chihao , Liu Yanqing , Fan Qian , Zhang Chen-Yu , Sang Jianfeng , Zen Ke , Chen Xi 
Published: November 2016

AbstractmicroRNAs (miRNAs) have emerged as major regulators of the initiation and progression of human cancers, including breast cancer. The aim of this study is to determine the expression pattern of miR-96 in breast cancer and to investigate its biological role during tumorigenesis. We showed that miR-96 was significantly upregulated in breast cancer. We then investigated its function and found that miR-96 significantly promoted cell proliferation, migration and invasion in vitro and enhanced tumor growth in vivo. Furthermore, we explored the molecular mechanisms by which miR-96 contributes to breast cancer progression and identified PTPN9 (protein tyrosine phosphatase, non-receptor type 9) as a direct target gene of miR-96. Finally, we showed that PTPN9 had opposite effects to those of miR-96 on breast cancer cells, suggesting that miR-96 may promote breast tumorigenesis by silencing PTPN9. Taken together, this study highlights an important role for miR-96 in the regulation of PTPN9 in breast cancer cells and may provide insight into the molecular mechanisms of breast carcinogenesis.
Electronic structure of organometal halide perovskite CH3NH3BiI3 and optical absorption extending to infrared region
Authors: Zhu H. X. , Liu J.-M. 
Published: November 2016

AbstractThe electronic structure and optical absorption spectrum of organometal halide perovskite compound CH3NH3BiI3 as a substituting candidate of well-concerned CH3NH3PbI3 not only for environmental friendly consideration are studied using the first principles calculations. It is revealed that a Bi replacement of Pb in CH3NH3PbI3 does not change seriously the band edge structure but the bandgap becomes narrow. Consequently, CH3NH3BiI3 exhibits not only stronger visible light absorption than CH3NH3PbI3 does but more strong absorption in the infrared region, which is however absent in CH3NH3PbI3. It is suggested that CH3NH3BiI3 may be one of even more promising alternatives to CH3NH3PbI3 for spectrum-broad and highly-efficient solar cells.
Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease
Authors: Wang Xianli , Dong Chuanming , Sun Lixin , Zhu Liang , Sun Chenxi , Ma Rongjie , Ning ke , Lu Bing , Zhang Jinfu , Xu Jun 
Published: November 2016

AbstractAging is characterized by a progressive decline in the function of adult tissues which can lead to neurodegenerative disorders. However, little is known about the correlation between protein changes in the subventricular zone (SVZ) and neurodegenerative diseases with age. In the present study, neural stem cells (NSCs) were derived from the SVZ on postnatal 7 d, 1 m, and 12 m-old mice. With age, NSCs exhibited increased SA-β-gal activity and decreased proliferation and pool size in the SVZ zone, and were associated with elevated inflammatory chemokines and cytokines. Furthermore, quantitative proteomics and ingenuity pathway analysis were used to evaluate the significant age-related alterations in proteins and their functions. Some downregulated proteins such as DPYSL2, TPI1, ALDH, and UCHL1 were found to play critical roles in the neurological disease and PSMA1, PSMA3, PSMC2, PSMD11, and UCHL1 in protein homeostasis. Taken together, we have provided valuable insight into the cellular and molecular processes that underlie aging-associated declines in SVZ neurogenesis for the early detection of differences in gene expression and the potential risk of neurological disease, which is beneficial in the prevention of the diseases.
A Nonparametric Regression Approach to Control for Population Stratification in Rare Variant Association Studies
Authors: Sha Qiuying , Zhang Kui , Zhang Shuanglin 
Published: November 2016

AbstractRecently, there is increasing interest to detect associations between rare variants and complex traits. Rare variant association studies usually need large sample sizes due to the rarity of the variants, and large sample sizes typically require combining information from different geographic locations within and across countries. Although several statistical methods have been developed to control for population stratification in common variant association studies, these methods are not necessarily controlling for population stratification in rare variant association studies. Thus, new statistical methods that can control for population stratification in rare variant association studies are needed. In this article, we propose a principal component based nonparametric regression (PC-nonp) approach to control for population stratification in rare variant association studies. Our simulations show that the proposed PC-nonp can control for population stratification well in all scenarios, while existing methods cannot control for population stratification at least in some scenarios. Simulations also show that PC-nonp’s robustness to population stratification will not reduce power. Furthermore, we illustrate our proposed method by using whole genome sequencing data from genetic analysis workshop 18 (GAW18).
Fabrication, Characterization and Response Surface Method (RSM) Optimization for Tetracycline Photodegration by Bi3.84W0.16O6.24- graphene oxide (BWO-GO)
Authors: Song Chengjie , Li Xinying , Wang Liping , Shi Weidong 
Published: November 2016

AbstractRSM is a powerful tool for optimizing photocatalytic processes. The BWO-GO photocatalysts have been successfully synthesized via inorganic-salt-assisted hydrothermal method. XRD, TEM, FESEM, HRTEM and STEM are used to characterize BWO-GO heterojunction. UV-vis, PL, ESR and radical scavenger experiments are used to explore the photocatalysis mechanism. The photocatalysts are evaluated by TC photodegradation under visible light irradiation. And the main active species in TC photodegradation is ·O2−. Response surface methodology is used to optimize three key independent operating parameters, namely photocatalyst dosage (X1), percentages of GO (X2) and reaction time (X3), for TC photodegradation. The central composite design (CCD) is used to conduct experiments. The results showed that TC removal is significantly affected by the synergistic effect of linear term of X1 and X3. However, the quadratic terms of X12 and X32 had an antagonistic effect on T removal. The obtained RSM model (R2 = 0.9206) shows a satisfactory correlation between experimental and predicted values of TC removal. The optimized conditions is of 0.3 g photocatalyst dosage, 1.49 wt% GO loaded percentage and 90 min reaction time. Under this condition, theoretical prediction removal is 80.22% and the actual removal is 78.43%.
Dopamine regulates renal osmoregulation during hyposaline stress via DRD1 in the spotted scat (Scatophagus argus)
Authors: Su Maoliang , Mu Xingjiang , Gui Lang , Zhang Peipei , Zhou Jianan , Ma Jie , Zhang Junbin 
Published: November 2016

AbstractDopamine is an important regulator of renal natriuresis and is critical for the adaptation of many animals to changing environmental salinity. However, the molecular mechanisms through which dopamine promotes this adaptation remain poorly understood. We studied the effects of dopamine on renal hypo-osmoregulation in the euryhaline fish Scatophagus argus (S. argus) during abrupt transfer from seawater (SW) to freshwater (FW). Following the transfer, serum dopamine concentration was decreased, and dopamine activated expression of the dopamine receptor 1 (designated SaDRD1) in the kidney, triggering the osmoregulatory signaling cascade. SaDRD1 protein is expressed in the renal proximal tubule cells in vivo, and is localized to the cell membrane of renal primary cells in vitro. Knockdown of SaDRD1 mRNA by siRNA significantly increased Na+/K+-ATPase (NKA) activity in cultured renal primary cells in vitro, suggesting that expression of SaDRD1 may oppose the activity of NKA. We demonstrate that exogenous dopamine enhances the response of NKA to hyposaline stress after transferring primary renal cells from isosmotic medium to hypoosmotic medium. Our results indicate that dopamine regulation via SaDRD1 ignited the renal dopaminergic system to balance the osmotic pressure through inhibiting NKA activity, providing a new perspective on the hyposaline adaptation of fish.
Sternal Resection for Breast Cancer Metastases
Authors: Baldes Natalie , Schirren Moritz , Oguzhan Selma , Menke Henrik , Schirren Joachim , Sponholz Stefan 
Published: November 2016

Background Sternal infiltration of breast cancer (BC) is a rare but known phenomenon. Sternal resection for this cancer is not completely investigated. For this reason, the aim of this study was to examine long-term survival and prognosticators for prolonged survival of our patients after sternal resection. Also, morbidity and mortality were investigated.
Materials and Methods We retrospectively analyzed our prospective database of 20 patients who underwent a sternum resection (partial/complete) for BC in our institution between 2003 and 2014. Furthermore, patients with additional lung metastases were included. All patients received a mesh-methyl methacrylate technique (“sandwich technique”) and soft tissue coverage with myocutaneous muscle flap. Long-term outcomes and survival curves were performed by the Kaplan–Meier method. Survival differences and prognosticators were investigated using the log-rank test.
Results Median survival was 32 months (95% confidence interval, 8–56 months). One-, 3-, and 5-year overall survivals were 79, 39, and 39%. There was a low morbidity and mortality with 35% (minor complications 30% and major complications 5%) and 0%. As prognosticators for longer survival, a positive hormone status (estrogen or progesterone) (p = 0.070) showed a trend. Neither age, primary mastectomy, disease-free interval < 24 months, primary N-status, nor preoperative chemotherapy showed a significant influence on survival. Furthermore, additional lung metastases did not influence survival significantly (p = 0.826).
Conclusion Sternal resections for BC patients can be associated with promising long-term survival. R0 resection, good functional and cosmetic results are achievable with low morbidity and mortality. Patients with additional lung metastases should not be routinely excluded from resection and should be discussed in interdisciplinary tumor boards.
Multiplex social ecological network analysis reveals how social changes affect community robustness more than resource depletion
Authors: Baggio Jacopo A. , BurnSilver Shauna B. , Arenas Alex , Magdanz James S. , Kofinas Gary P. , De Domenico Manlio 
Published: November 2016

Significance
Social capital ties are ubiquitous in modern life. For societies with people and landscapes tightly connected, in variable or marginal ecosystems, and with unreliable market sectors, social relations are critical. Each relation is a potential source of food, information, cash, labor, or expertise. Here, we present an analysis of multiplex, directed, and weighted networks representing actual flows of subsistence-related goods and services among households in three remote indigenous Alaska communities exposed to both extreme climate change and industrial development. We find that the principal challenge to the robustness of such communities is the loss of key households and the erosion of cultural ties linked to sharing and cooperative social relations rather than resource depletion.
Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers
Authors: Alaei-Mahabadi Babak , Bhadury Joydeep , Karlsson Joakim W. , Nilsson Jonas A. , Larsson Erik 
Published: November 2016

Significance
Structural changes in chromosomes can alter the expression and function of genes in tumors, an important driving mechanism in some tumors. Whole-genome sequencing makes it possible to detect such events on a genome-wide scale, but comprehensive investigations are still missing. Here, enabled by a massive amount of whole-genome sequencing data generated by The Cancer Genome Atlas consortium, we map somatic structural changes in 600 tumors of diverse origins. At a global level, we find that such events often contribute to altered gene expression in human cancer, and also highlight specific events that may have functional roles during tumor development.
Uterine Artery Embolization Versus Hysterectomy in the Treatment of Symptomatic Uterine Fibroids: 10 Years’ Outcomes From the Randomized EMMY Trial
Authors: de Bruijn Annefleur M. , Ankum Willem M. , Reekers Jim A. , Birnie Erwin , van der Kooij Sanne M. , Volkers Nicole A. , Hehenkamp Wouter J. K. 
Published: November 2016

(Abstracted from Am J Obst Gynecol 2016; DOI: 10.1016/j.ajog.2016.06.051)
Since uterine artery embolization (UAE) was first described in 1995 as an alternative to hysterectomy for the treatment of symptomatic uterine fibroids, a large number of studies including several randomized controlled trials have established UAE as a valuable treatment. The randomized EMMY (EMbolization versus hysterectoMY) trial reported outcomes for clinical outcomes, efficacy, health-related quality of life (HRQOL), and cost-effectiveness after 1, 2, and 5 years of follow-up.
The Investigations Required Before Referring a Patient to a Gynaecologic Oncologist
Authors: Kupets Rachel , Christopher Giede K. , Power Patti , Agrawal Anita 
Published: November 2016

(Abstracted from J Obstet Gynaecol Can 2016;38:164–167)
The majority of women who develop gynecologic malignancies initially present to family physicians or generalist obstetrician-gynecologists before referral to gynecologic oncologists. Nonsubspecialists may order a number of investigative procedures prior to referral of women with suspected gynecologic cancers.
Mouse Model of Chromosome Mosaicism Reveals Lineage-Specific Depletion of Aneuploid Cells and Normal Developmental Potential
Authors: Bolton Helen , Graham Sarah J. L. , van der Aa Niels , Kumar Parveen , Theunis Koen , Gallardo Elia Fernandez , Voet Thierry , Zernicka-Goetz Magdalena 
Published: November 2016

(Abstracted from Nat Commun 2016;7:11165)
Most human preimplantation embryos display chromosome mosaicism. In the most common pattern of mosaicism, the embryo is chimeric (containing both euploid and aneuploid cells).
Are Hypertensive Disorders in Pregnancy Associated With Congenital Malformations in Offspring? Evidence From the WHO Multicountry Cross Sectional Survey on Maternal And Newborn Health
Authors: Bellizzi S. , Ali M. M. , Abalos E. , Betran A. P. , Kapila J. , Pileggi-Castro C. , Vogel J. P. , Merialdi M. 
Published: November 2016

(Abstracted from BMC Pregnancy Childbirth 2016;16:198)
Approximately 7.9 million children are born with birth defects, and 3.3 million children younger than 5 years die because of congenital anomalies annually. It is well known that congenital malformations contribute significantly to neonatal mortality.
Temporal Trends in Late Preterm and Early Term Birth Rates in 6 High-Income Countries in North America and Europe and Association With Clinician-Initiated Obstetric Interventions
Authors: Richards Jennifer L. , Kramer Michael S. , Deb-Rinker Paromita , Rouleau Jocelyn , Mortensen Laust , Gissler Mika , Morken Nils-Halvdan , Skjærven Rolv , Cnattingius Sven , Johansson Stefan , Delnord Marie , Dolan Siobhan M. , Morisaki Naho , Tough Suzanne , Zeitlin Jennifer , Kramer Michael R. 
Published: November 2016

(Abstracted from JAMA 2016;316(4):410–419)
Late-preterm and early-term births occurring spontaneously or through obstetric interventions including labor induction or cesarean delivery are a cause for concern because of consequent risks of adverse neonatal and childhood outcomes. Hence, recommendations in the United States have been to decrease nonmedically indicated or elective deliveries before 39 weeks.
Dendritic cell subset expression in severe chronic rhinosinusitis with nasal polyps
Authors: Perez-Novo Claudina , Pezato Rogério 
Published: November 2016

Purpose of review
Two main pillars are implicated in nasal polyposis development: a severe imbalance in immunomodulation and a mechanical dysfunction because of an abnormal remodeling process. Dendritic cells play a crucial role in the link between innate and adaptive immune response and orchestrating the T-cell response and are implicated in the severe inflammatory process found in nasal polypoid tissue. This review summarizes the existent knowledge about dendritic cells in nasal polyposis.

Recent findings
Dendritic cells are found increased in nasal polyposis, regardless of subset. Of interest, plasmacytoid dendritic cells are decreased in patients with a more severe Th2 profile, suggesting an important role of the cytokines milieu in their functional response or that plasmacytoid dendritic cell could act mitigating the inflamed process found in polypoid tissue.

Summary
Understanding the dendritic cell subset expression in different environments, as well as the effect of these subsets on T-cell differentiation will greatly improve the development of new therapies in nasal polyposis.