bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Fabp1/Scp‐2/Scp‐x Ablation on Whole Body and Hepatic Phenotype of Phytol‐Fed Male Mice
Authors: Landrock Danilo , Milligan Sherrelle , Martin Gregory G. , McIntosh Avery L. , Landrock Kerstin K. , Schroeder Friedhelm , Kier Ann B. 
Published: April 2017

AbstractLiver fatty acid binding protein (Fabp1) and sterol carrier protein‐2/sterol carrier protein‐x (SCP‐2/SCP‐x) genes encode proteins that enhance hepatic uptake, cytosolic transport, and peroxisomal oxidation of toxic branched‐chain fatty acids derived from dietary phytol. Since male wild‐type (WT) mice express markedly higher levels of these proteins than females, the impact of ablating both genes (TKO) was examined in phytol‐fed males. In WT males, high phytol diet alone had little impact on whole body weight and did not alter the proportion of lean tissue mass (LTM) versus fat tissue mass (FTM). TKO conferred on dietary phytol the ability to induce weight loss as well as reduce liver weight, FTM, and even more so LTM. Concomitantly TKO induced hepatic lipid accumulation, preferentially threefold increased phospholipid (PL) at the expense of decreased triacylglycerol (TG) and total cholesterol. Increased PL was associated with upregulation of membrane fatty acid transport/translocase proteins (FATP 2,4), cytosolic fatty acid/fatty acyl‐CoA binding proteins (FABP2, ACBP), and the rate limiting enzyme in PL synthesis (Gpam). Decreased TG and cholesterol levels were not attributable to altered levels in respective synthetic enzymes or nuclear receptors. These data suggest that the higher level of Fabp1 and Scp2/Scpx gene products in WT males was protective against deleterious effects of dietary phytol, but TKO significantly exacerbated phytol effects in males.
On the influence of Si:Al ratio and hierarchical porosity of FAU zeolites in solid acid catalysed esterification pretreatment of bio-oil
Authors: Osatiashtiani Amin , Puértolas Begoña , Oliveira Caio C. S. , Manayil Jinesh C. , Barbero Brunella , Isaacs Mark , Michailof Chrysoula , Heracleous Eleni , Pérez-Ramírez Javier , Lee Adam F. , Wilson Karen 
Published: April 2017

AbstractA family of faujasite (FAU) zeolites with different Si:Al ratio, and/or hierarchical porosity introduced via post-synthetic alkaline desilication treatment, have been evaluated as solid acid catalysts for esterification pretreatments of pyrolysis bio-oil components. Acetic acid esterification with aliphatic and aromatic alcohols including methanol, anisyl alcohol, benzyl alcohol, p-cresol and n-butanol was first selected as a model reaction to identify the optimum zeolite properties. Materials were fully characterised using N2 porosimetry, ICP, XRD, XPS, FT-IR, pyridine adsorption, NH3 TPD, In-situ ATR and inverse gas chromatography (IGC). IGC demonstrates that the surface polarity and hence hydrophobicity of FAU decreases with increased Si:Al ratio. Despite possessing a higher acid site loading and acetic acid adsorption capacity, high Al-content FAU possess weaker acidity than more siliceous catalysts. Esterification activity increases with acid strength and decreasing surface polarity following the order FAU30>FAU6>FAU2.6. The introduction of mesoporosity through synthesis of a hierarchical HFAU30 material further enhances esterification activity through improved acid site accessibility and hydrophobicity. Methanol was the most reactive alcohol for esterification, and evaluated with HFAU30 for the pretreatment of a real pyrolysis bio-oil, reducing the acid content by 76% under mild conditions.
Prognosis in Congenital Diaphragmatic Hernia Diagnosed During Fetal Life
Authors: Morgan Tara A. , Shum Dorothy J. , Basta Amaya M. , Filly Roy A. 
Published: April 2017

AbstractCongenital diaphragmatic hernia (CDH) is a malformation that continues to cause significant morbidity and mortality and can be difficult to clinically manage. Determination of prognosis can greatly add to the decision-making process in prenatally recognized CDH, predominantly by the recognition of specific ultrasound findings. Ultrasound findings that are important include hernia type, laterality, lung size, position of the fetal liver and stomach, and the presence or absence of other anomalies. In general, prognosis is best in cases where CDH is an isolated anomaly, the liver and stomach remain within the abdominal cavity, and the lung size corresponds to a lung area to head circumference ratio of ≥1. Position of the stomach also corresponds with prognosis, is easier to reliably determine with ultrasound, and can indirectly predict the position of the liver. The following is a review of the literature and experience in the care of fetuses with CDH at the University of California, San Francisco, a large tertiary referral center, in using these ultrasound findings to predict prognosis.
Language, procedures, and the non-perceptual origin of number word meanings
Authors: BARNER DAVID 
Published: April 2017

AbstractPerceptual representations of objects and approximate magnitudes are often invoked as building blocks that children combine to acquire the positive integers. Systems of numerical perception are either assumed to contain the logical foundations of arithmetic innately, or to supply the basis for their induction. I propose an alternative to this framework, and argue that the integers are not learned from perceptual systems, but arise toexplainperception. Using cross-linguistic and developmental data, I show that small (~1–4) and large (~5+) numbers arise both historically and in individual children via distinct mechanisms, constituting independent learning problems, neither of which begins with perceptual building blocks. Children first learn small numbers using the same logic that supports other linguistic number marking (e.g. singular/plural). Years later, they infer the logic of counting from the relations between large number words and their roles in blind counting procedures, only incidentally associating number words with approximate magnitudes.
‘Chamber within a chamber’: a rare cardiac anomaly
Authors: Ghosh Gopal C. , Alex Anoop G. , George Paul V. 
Published: April 2017

AbstractDouble-chambered left ventricle is a rare cardiac anomaly. We report a case of double-chambered left ventricle in a one-and-half-year-old asymptomatic boy. We depict the use of three-dimensional echocardiography in the demonstration and diagnosis of the condition.
Self-Perception of Medical Students’ Knowledge and Interest in Disaster Medicine: Nine Years After the Approval of the Curriculum in German Universities
Authors: Wunderlich Robert , Ragazzoni Luca , Ingrassia Pier Luigi , Corte Francesco Della , Grundgeiger Jan , Bickelmayer Jens Werner , Domres Bernd 
Published: April 2017

AbstractBackgroundFollowing the recommendations of the World Association for Disaster and Emergency Medicine (WADEM; Madison, Wisconsin USA) to develop standards for training the undergraduates in disaster-relevant fields (2004), a German curriculum was approved in 2006. This paper aims to describe the level of training and interest of medical students nine years later.ProblemThe aim of this study was to assess the self-perception of medical students’ knowledge and interest in disaster medicine nine years after the implementation of a standardized disaster medicine curriculum in German medical schools.MethodsThis prospective, cross-sectional, observational study was conducted with medical students in Germany using a web-based, purpose-designed questionnaire consisting of 27 mandatory and 11 optional questions.ResultsNine hundred ninety-two students from 36 of 37 medical schools in Germany participated. More than one-half of medical students were aware of the field of disaster medicine. One hundred twenty-one students undertook training internally within their university and 307 undertook training externally at other institutions. Only a small content of the curriculum was taught. A difference in self-perception of knowledge between trained and untrained participants was found, despite the level of training being low in both groups. Participants were generally highly motivated to learn disaster medicine in a variety of institutions.ConclusionGerman students are still largely not well educated regarding disaster medicine, despite their high motivation. The curriculum of 2006 was not implemented as originally planned and the number of trained students still remains low as the self-perception of knowledge. Currently, there is no clear and standardized training concept in place. A renewal in the agreement of implementation of the curriculum at medical schools should be targeted in order to follow the recommendation of WADEM.WunderlichRRagazzoniLIngrassiaPLDella CorteFGrundgeigerJBickelmayerJWDomresB. Self-perception of medical students’ knowledge and interest in disaster medicine: nine years after the approval of the curriculum in German universities. Prehosp Disaster Med. 2017;32(4):374–381.
Mütterliches Expressed Emotion und elterliche Angst vor negativer Bewertung bei Kindern mit sozialer Angststörung
Authors: Asbrand Julia , Heinrichs Nina , Tuschen-Caffier Brunna 
Published: April 2017

Zusammenfassung. Theoretischer Hintergrund: Ziel dieser Studie ist die Untersuchung von Expressed Emotion (EE) als Faktor des familiären Klimas sowie elterlicher Angst vor negativer Bewertung des Kindes als potentieller Mediator für den Zusammenhang von sozialer Angst der Eltern und Kinder. Methode: Kinder mit Sozialer Angststörung (SAS; n = 64) und ohne SAS (healthy control, HC, n = 52) sowie deren Eltern (Mütter und Väter) berichteten über eigene soziale Ängste und ihre Angst vor negativer Bewertung des Kindes. Mütter nahmen zudem am Five Minute Speech Sample (FMSS) zur Erhebung von EE teil. Ergebnisse: Berichte von Müttern von Kindern mit einer SAS wurden häufiger als High Expressed Emotion (HEE) eingestuft als Berichte von Müttern von HC Kindern. Es zeigte sich ein Zusammenhang von EE und sozialer Angst der Mutter wie auch mütterlicher Angst vor negativer Bewertung des Kindes. Zudem wurde der Zusammenhang zwischen kindlicher und mütterlicher sozialer Angst partiell durch die Angst vor negativer Bewertung des Kindes mediiert. Schlussfolgerungen: Es konnte ein Zusammenhang von kindlicher SAS und gleichzeitig erhöhtem EE der Mütter gezeigt werden. Erhöhte Angst vor negativer Bewertung des Kindes stellt einen potenziellen Mechanismus dar, wie mütterliche, nicht aber väterliche, soziale Angst an das Kind vermittelt werden kann.
Composite functional metasurfaces for multispectral achromatic optics
Authors: Avayu Ori , Almeida Euclides , Prior Yehiam , Ellenbogen Tal 
Published: April 2017

AbstractNanostructured metasurfaces offer unique capabilities for subwavelength control of optical waves. Based on this potential, a large number of metasurfaces have been proposed recently as alternatives to standard optical elements. In most cases, however, these elements suffer from large chromatic aberrations, thus limiting their usefulness for multiwavelength or broadband applications. Here, in order to alleviate the chromatic aberrations of individual diffractive elements, we introduce dense vertical stacking of independent metasurfaces, where each layer is made from a different material, and is optimally designed for a different spectral band. Using this approach, we demonstrate a triply red, green and blue achromatic metalens in the visible range. We further demonstrate functional beam shaping by a self-aligned integrated element for stimulated emission depletion microscopy and a lens that provides anomalous dispersive focusing. These demonstrations lead the way to the realization of ultra-thin superachromatic optical elements showing multiple functionalities—all in a single nanostructured ultra-thin element.
Quantum sampling problems, BosonSampling and quantum supremacy
Authors: Lund A. P. , Bremner Michael J. , Ralph T. C. 
Published: April 2017

AbstractThere is a large body of evidence for the potential of greater computational power using information carriers that are quantum mechanical over those governed by the laws of classical mechanics. But the question of the exact nature of the power contributed by quantum mechanics remains only partially answered. Furthermore, there exists doubt over the practicality of achieving a large enough quantum computation that definitively demonstrates quantum supremacy. Recently the study of computational problems that produce samples from probability distributions has added to both our understanding of the power of quantum algorithms and lowered the requirements for demonstration of fast quantum algorithms. The proposed quantum sampling problems do not require a quantum computer capable of universal operations and also permit physically realistic errors in their operation. This is an encouraging step towards an experimental demonstration of quantum algorithmic supremacy. In this paper, we will review sampling problems and the arguments that have been used to deduce when sampling problems are hard for classical computers to simulate. Two classes of quantum sampling problems that demonstrate the supremacy of quantum algorithms are BosonSampling and Instantaneous Quantum Polynomial-time Sampling. We will present the details of these classes and recent experimental progress towards demonstrating quantum supremacy in BosonSampling.
Development of Mixed metal Metal-organic polyhedra networks, colloids, and MOFs and their Pharmacokinetic applications
Authors: Ahmad Nazir , Younus Hussein A. , Chughtai Adeel H. , Van Hecke Kristof , Danish Muhammad , Gaoke Zhang , Verpoort Francis 
Published: April 2017

SummaryThe coordination networking of discrete metal-organic polyhedra (MOPs) involving different ligands as well as metals is a challenging task due to the features of limited solubility and chemical stability of these polyhedra. An unusual approach, ligand-oriented polyhedral networking via click chemistry and further metal coordination is reported here. An alkyne decorated Cu(II)-MOP self-catalyzes the regioselective click reaction (1,3-dipolar cycloaddition) using azide-functionalized ligands under unconventional reaction conditions. Introducing new metal ions, M(II), interlinks the carboxylic groups on the MOP surfaces creating coordination networks. On the other hand, exposure of the respective individual ligand components in the presence of Cu(II) promotes an in-situ click reaction along with metal coordination generating a new 3D-framework. These materials demonstrated a high drug hosting potential exhibiting a controlled progressive release of anticancer (5-flourouracil) and stimulant (caffeine) drugs in physiological saline at 37 °C. These innovative and unconventional MOP networks provide a significant conceptual advance in understanding.
Excitation Intensity Dependent Carrier Dynamics of Chalcogen Heteroatoms in Medium-Bandgap Polymer Solar Cells
Authors: Kulshreshtha Chandramouli , Son Jiwon , Pascher Torbjörn , Kim Ji-Hee , Joo Taiha , Lee Jaewon , Jeong Mun Seok , Cho Kilwon 
Published: April 2017

AbstractThe excitation intensity dependent carrier dynamics of blends with PC[70]BM of three new medium-band gap conjugated polymers with central chalcogen heteroatoms, PBDTfDTBX (X = O, T(Sulphur), Se) were studied. The PBDTfDTBX polymers (Poly[4,8-bis(5-(2-butyloctyl)thiophene-2-yl)benzo[1,2-b;4,5-b′]dithiophene-alt-4,7-bis(4-(2-ethylhexyl)-2-thienyl)-dithieno[3′,2′:3,4;2″,3″:5,6]benzo[1,2-c][1,2,5] furazan or thiadiazole or selenadiazole]) have symmetrical structures but exhibit different solar cell performances. In this study, we determined how the photogenerated charge carrrier dynamics of the PBDTfDTBX:PC[70]BM blends varies with the heteroatom by performing transient absorption measurements at various excitation intensities. It was found that the charge carrier dynamics of the PBDTfDTBX blends with X = T or Se heteroatoms are dependent on the excitation intensity whereas that of the PBDTfDTBO blend is independent of the intensity. The photogenerated charge carrier dynamics of the PBDTfDTBO:PCBM, PBDTfDTBT:PCBM, and PBDTfDTBSe:PCBM blends were all modeled globally and rates were estimated for different photophysical processes occurring on different time scales.
The effect of the teeth bleaching with 35% hydrogen peroxide on the tensile bond strength of metal brackets
Authors: Trakiniene Giedre , Daukontiene Simona , Jurenas Vytautas , Svalkauskiene Vilma , Smailiene Dalia , Lopatiene Kristina , Trakinis Tomas 
Published: April 2017

AbstractThe objective of this study was to determine the effects of teeth bleaching on the tensile bond strength of metal brackets bonded with light-curing adhesive system to the human enamel. 40 recently extracted human permanent molars were used for the study. The mesial buccal surface of each tooth was used as a control group and the distal buccal surface was used as an experimental group. Control group surfaces were not submitted to bleaching, while experimental group surfaces were bleached with in-office bleaching material containing 35% hydrogen peroxide. 30 days after the bleaching, identical premolar metal brackets were bonded to each surface using light-curing adhesive. Both groups were submitted to a tension test, using a universal machine. The tensile bond strength of brackets bonded to the bleached enamel was 15% lower than that of brackets bonded to the unbleached enamel. After debonding, more adhesive was left on the bracket base in experimental group than in the control group. The conclusion of this study was that bleaching with an in-office bleaching material containing 35% hydrogen peroxide reduced the tensile bond strength of orthodontic bracket adhesive to the enamel surface.
A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis
Authors: Misselbeck Karla , Marchetti Luca , Field Martha S. , Scotti Marco , Priami Corrado , Stover Patrick J. 
Published: April 2017

AbstractFolate-mediated one-carbon metabolism (FOCM) is an interconnected network of metabolic pathways, including those required for the de novo synthesis of dTMP and purine nucleotides and for remethylation of homocysteine to methionine. Mouse models of folate-responsive neural tube defects (NTDs) indicate that impaired de novo thymidylate (dTMP) synthesis through changes in SHMT expression is causative in folate-responsive NTDs. We have created a hybrid computational model comprised of ordinary differential equations and stochastic simulation. We investigated whether the de novo dTMP synthesis pathway was sensitive to perturbations in FOCM that are known to be associated with human NTDs. This computational model shows that de novo dTMP synthesis is highly sensitive to the common MTHFR C677T polymorphism and that the effect of the polymorphism on FOCM is greater in folate deficiency. Computational simulations indicate that the MTHFR C677T polymorphism and folate deficiency interact to increase the stochastic behavior of the FOCM network, with the greatest instability observed for reactions catalyzed by serine hydroxymethyltransferase (SHMT). Furthermore, we show that de novo dTMP synthesis does not occur in the cytosol at rates sufficient for DNA replication, supporting empirical data indicating that impaired nuclear de novo dTMP synthesis results in uracil misincorporation into DNA.
An evaluation of the ecological and environmental security on China’s terrestrial ecosystems
Authors: Zhang Hongqi , Xu Erqi 
Published: April 2017

AbstractWith rapid economic growth, industrialization, and urbanization, various ecological and environmental problems occur, which threaten and undermine the sustainable development and domestic survival of China. On the national scale, our progress remains in a state of qualitative or semi-quantitative evaluation, lacking a quantitative evaluation and a spatial visualization of ecological and environmental security. This study collected 14 indictors of water, land, air, and biodiversity securities to compile a spatial evaluation of ecological and environmental security in terrestrial ecosystems of China. With area-weighted normalization and scaling transformations, the veto aggregation (focusing on the limit indicator) and balanced aggregation (measuring balanced performance among different indicators) methods were used to aggregate security evaluation indicators. Results showed that water, land, air, and biodiversity securities presented different spatial distributions. A relatively serious ecological and environmental security crisis was found in China, but presented an obviously spatial variation of security evaluation scores. Hotspot areas at the danger level, which are scattered throughout the entirety of the country, were identified. The spatial diversities and causes of ecological and environmental problems in different regions were analyzed. Spatial integration of regional development and proposals for improving the ecological and environmental security were put forward.
High Throughput Analysis of Golgi Structure by Imaging Flow Cytometry
Authors: Wortzel Inbal , Koifman Gabriela , Rotter Varda , Seger Rony , Porat Ziv 
Published: April 2017

AbstractThe Golgi apparatus is a dynamic organelle, which regulates the vesicular trafficking. While cellular trafficking requires active changes of the Golgi membranes, these are not accompanied by changes in the general Golgi’s structure. However, cellular processes such as mitosis, apoptosis and migration require fragmentation of the Golgi complex. Currently, these changes are most commonly studied by basic immunofluorescence and quantified by manual and subjective classification of the Golgi structure in 100–500 stained cells. Several other high-throughput methods exist as well, but those are either complicated or do not provide enough morphological information. Therefore, a simple and informative high content methodology should be beneficial for the study of Golgi architecture. Here we describe the use of high-throughput imaging flow cytometry for quantification of Golgi fragmentation, which provides a simple way to analyze the changes in an automated, quantitative and non-biased manner. Furthermore, it provides a rapid and accurate way to analyze more than 50,000 cells per sample. Our results demonstrate that this method is robust and statistically powerful, thus, providing a much-needed analytical tool for future studies on Golgi dynamics, and can be adapted to other experimental systems.
Granulosa cell endothelin-2 expression is fundamental for ovulatory follicle rupture
Authors: Cacioppo Joseph A. , Lin Po-Ching Patrick , Hannon Patrick R. , McDougle Daniel R. , Gal Arnon , Ko CheMyong 
Published: April 2017

AbstractOvulation is dependent upon numerous factors mediating follicular growth, vascularization, and ultimately oocyte release via follicle rupture. Endothelin-2 (EDN2) is a potent vasoconstrictor that is transiently produced prior to follicle rupture by granulosa cells of periovulatory follicles and induces ovarian contraction. To determine the role of Edn2 expression, surgical transplant and novel conditional knockout mice were super-ovulated and analyzed. Conditional knockout mice utilized a new iCre driven by the Esr2 promoter to selectively remove Edn2. Follicle rupture and fertility were significantly impaired in the absence of ovarian Edn2 expression. When ovaries of Edn2KO mice were transplanted in wild type recipients, significantly more corpora lutea containing un-ovulated oocytes were present after hormonal stimulation (1.0 vs. 5.4, p = 0.010). Following selective ablation of Edn2 in granulosa cells, Esr2-Edn2KO dams had reduced oocytes ovulated (3.8 vs. 16.4 oocytes/ovary) and smaller litters (4.29 ± l.02 vs. 8.50 pups/dam). However, the number of pregnancies per pairing was not different and the reproductive axis remained intact. Esr2-Edn2KO ovaries had a higher percentage of antral follicles and fewer corpora lutea; follicles progressed to the antral stage but many were unable to rupture. Conditional loss of endothelin receptor A in granulosa cells also decreased ovulation but did not affect fecundity. These data demonstrate that EDN2-induced intraovarian contraction is a critical trigger of normal ovulation and subsequent fecundity.