bluuebunny/crossref_metadata_2025_split huggingface dataset:
PARA ALÉM DO GUGGENHEIM, RUMO À ISLA CREATIVA
Authors: Freire Costa Andrea Virgínia , Nascimento José Clewton do 
Published: September 2024

Este artigo discute como o conceito de cidade criativa vem sendo incorporado ao planejamento urbano de Bilbao, na Espanha, ao longo dos últimos vinte anos, enfocando sua trajetória histórica, intervenções no espaço urbano e os conflitos sociais emergentes desse processo. Entende-se que as cidades criativas são aquelas que consideram o uso da criatividade urbana como um elemento fundamental para alcançar o desenvolvimento sustentável e, por isso, nos planos de desenvolvimento local, irão buscar fortalecer os setores ligados à economia criativa, além de atuarem de forma cooperativa em rede internacional Unesco, 2004; 2021). Para isso, foram considerados os estudos publicados pela associação Bilbao Metropoli-30, pela sociedade Bilbao Ria 2000 e relacionados ao Projeto Zorrotzaurre, focando nos discursos relacionados ao incremento da economia criativa e/ou que evidenciam o uso da arte, cultura e criatividade para o desenvolvimento urbano, social e econômico. Como resultados encontrados, verifica-se que, o uso da cultura no Plan Estratégico para la Revitalización del Bilbao Metropolitano (1992), foi intensificado e ampliado no Projeto Zorrotzaurre (2012) alinhado-o à ideia de cidade criativa. Desse modo, aponta-se que Bilbao caminha para um novo momento de regeneração urbana, marcado, por um lado, pelo fortalecimento das indústrias criativas e pela apropriação de valores locais intangíveis pelo mercado; e, por outro, pela possibilidade de disputa e construção do conceito de cidade criativa com a contribuição dos movimentos urbanos independentes, quer seja pela adoção de novas formas de governança urbana, quer sela pela serendipidade e imprevisibilidade urbanas.
Implementation of flipped learning to increase student learning activeness in the combustion engine lecture
Authors: Ranto Ranto , Wulandari Antika , Rohman Ngatou 
Published: September 2024

This study aims to determine the increase in learning activeness of Sebelas Maret University students in the mechanical engineering education study program through the implementation of a flipped learning model in the combustion engine lecture. This research is classroom action research. The action taken is to apply the flipped learning model in the combustion engine lecture. The subjects of this study were 42 students in the second semester of the mechanical engineering education study program. This classroom action research design refers to the Kemmis and Taggart model. The research was conducted in three cycles, each consisting of planning, implementation, observation, and reflection. Data collection was done through observation, interviews, and documentation. The instrument validity test was carried out with construct validity using expert opinions. Data analysis was carried out in a comparative-descriptive way. The results of this classroom action research show that implementing the flipped learning model can increase the learning activeness of students in the combustion engine lecture. In the pre-cycle stage, student learning activeness only reached 45.24% of active learning students. In cycle 1, by implementing a flipped learning model, students learning activeness reached 81.99%, cycle 2 increased to 87.43%, and cycle 3 increased to 91.74%. The conclusion of this research is that the implementation of the flipped learning model can increase the learning activeness of the mechanical engineering education study program Sebelas Maret University students in the combustion engine lecture. Based on the results of this research, it is highly recommended to use the flipped learning model in lectures, especially in vocational education, increasing student learning activeness will have an impact on increasing student learning achievement.
Exploring Racial Disparities in Awareness and Perceptions of Oncology Clinical Trials: Cross-Sectional Analysis of Baseline Data From the mychoice Study
Authors: Hoadley Ariel , Fleisher Linda , Kenny Cassidy , Kelly Patrick JA , Ma Xinrui , Wu Jingwei , Guerra Carmen , Leader Amy E , Alhajji Mohammed , D’Avanzo Paul , Landau Zoe , Bass Sarah Bauerle 
Published: September 2024

Background
Black/African American adults are underrepresented in oncology clinical trials in the United States, despite efforts at narrowing this disparity.

Objective
This study aims to explore differences in how Black/African American oncology patients perceive clinical trials to improve support for the clinical trial participation decision-making process.

Methods
As part of a larger randomized controlled trial, a total of 244 adult oncology patients receiving active treatment or follow-up care completed a cross-sectional baseline survey on sociodemographic characteristics, clinical trial knowledge, health literacy, perceptions of cancer clinical trials, patient activation, patient advocacy, health care self-efficacy, decisional conflict, and clinical trial intentions. Self-reported race was dichotomized into Black/African American and non–Black/African American. As appropriate, 2-tailed t tests and chi-square tests of independence were used to examine differences between groups.

Results
Black/African American participants had lower clinical trial knowledge (P=.006), lower health literacy (P<.001), and more medical mistrust (all P values <.05) than non–Black/African American participants. While intentions to participate in a clinical trial, if offered, did not vary between Black/African American and non–Black/African American participants, Black/African American participants indicated lower awareness of clinical trials, fewer benefits of clinical trials, and more uncertainty around clinical trial decision-making (all P values <.05). There were no differences for other variables.

Conclusions
Despite no significant differences in intent to participate in a clinical trial if offered and high overall trust in individual health care providers among both groups, beliefs persist about barriers to and benefits of clinical trial participation among Black/African American patients. Findings highlight specific ways that education and resources about clinical trials could be tailored to better suit the informational and decision-making needs and preferences of Black/African American oncology patients.
The Integrating Cultural Aspects Into Diabetes Education (INCLUDE) Study to Prevent Diabetes in Chinese Immigrants: Protocol for a Randomized Controlled Trial
Authors: Hu Lu , Lin Nelson F , Shi Yun , Cao Jiepin , Sevick Mary Ann , Li Huilin , Beasley Jeannette M , Levy Natalie , Tamura Kosuke , Xu Xinyi , Jiang Yulin , Ong Iris , Yang Ximin , Bai Yujie , Su Liwen , Chan Sze Wan , Yi Stella S 
Published: September 2024

Background
Type 2 diabetes (T2D) contributes to significant morbidity and mortality for Chinese immigrants in the United States, exacerbated by social determinants of health (SDOH) barriers such as language barriers, limited access to healthy foods, and low health literacy.

Objective
The goal of the Integrating Cultural Aspects into Diabetes Education (INCLUDE) study is to test a social media–based intervention adapting the Diabetes Prevention Program (DPP) for Chinese immigrants alongside a culturally adapted, community-supported agriculture program. Here, we report the protocol for the INCLUDE study.

Methods
INCLUDE is a 3-year randomized controlled trial (n=150). Participants with prediabetes or at risk for T2D are enrolled and randomized into either the control or intervention group (n=75 each). Participants from the intervention group receive 2-3 culturally tailored, in-language DPP videos weekly for 12 weeks, as well as biweekly phone calls from bilingual study staff to review video content, support goal setting, and assess and address SDOH-related barriers such as food insecurity. Intervention participants will also be given produce for 10 weeks as part of the community-supported agriculture program. Weight (primary outcome), self-efficacy, diet, physical activity, and food insecurity (secondary outcomes) are measured at baseline, 3-month, and 6-month intervals. Splined linear mixed models will be used to examine group differences in longitudinal weight and other secondary outcomes. The INCLUDE study was approved by the Institutional Review Board at the NYU Grossman School of Medicine.

Results
Recruitment started in May 2023, with the first cohort of 75 participants enrolled and randomized into 2 groups in July 2023. The 3-month and 6-month assessment of the first-year cohort has been completed. We have recruited 75 participants for the second cohort as of July 2024.

Conclusions
The INCLUDE study will serve as an innovative model for culturally adapted, multilevel interventions for underserved communities previously unable to access evidence-based diabetes prevention initiatives. Aligning with several national calls for multilevel interventions, the INCLUDE intervention will provide critical data that will inform how researchers and public health professionals address SDOH barriers faced by underserved populations and prevent diabetes.

Trial Registration
ClinicalTrials.gov NCT05492916; https://clinicaltrials.gov/study/NCT05492916

International Registered Report Identifier (IRRID)
DERR1-10.2196/65455
Phytochemical, Nutraceutical and Pharmacological Aspects of the Philippine native Acalypha angatensis Blanco, Fl. Filip.
Authors: Hipol Regina Lourdes , Wayas Hilda , Bacuyag Florence Mae , Daquigan Madonna , Hipol Roland , Cabanlong Jedida 
Published: September 2024

The genus Acalypha has valuable species that have significant pharmaceutical applications. This study investigated the phytochemical composition and thin layer chromatography (TLC) profile, as well as the antioxidant and antibacterial activities of the ethanolic extract of Acalypha pulogensis Sagun & G.A. Levin, an endemic species in the Philippines. Qualitative phytochemical screening revealed the presence of tannins, phenolics, flavonoids, saponins, steroids, and triterpenoids. Nutrient analysis showed that potassium and calcium content were at 1499 mg/100 g and 1380 mg/100 g, respectively. The determination of the total phenolic content (TPC) showed that this species has an average of 282.24 ± 3.56 mg GAE/g and a total flavonoid content (TFC) of 36.24 ± 3.77 mg QE/g of dried extract. These values were found to be higher than those of other Acalypha species. Antioxidant activity was measured using DPPH antioxidant assay, and the extract showed a concentration-dependent radical scavenging effect with an IC50 of 34.02 µg/mL. Antibacterial activity was evaluated using various concentrations against drug-resistant Gram-positive and Gram-negative bacteria using a resazurin-based assay. The ethanolic extract exhibited substantial antibacterial activity against Enterococcus faecium (NCTC 12204) and MRSA (ATCC 33592), with a minimum inhibitory concentration (MIC) of 4 mg/mL. Higher concentrations (>20 mg/mL) were needed for inhibition of the Gram-negative strains (Klebsiella pneumoniae and Enterobacter cloacae). These results suggest that A. pulogensis has good antioxidant and antibacterial activities that support its use in traditional medicine.
In-hospital evolution of secondary mitral regurgitation in acutely decompensated heart failure
Authors: Cocianni Daniele , Perotto Maria , Barbisan Davide , Contessi Stefano , Rizzi Jacopo Giulio , Savonitto Giulio , Zocca Eugenio , Brollo Enrico , Soranzo Elisa , De Luca Antonio , Fabris Enrico , Merlo Marco , Sinagra Gianfranco , Stolfo Davide 
Published: September 2024

Aims
Secondary mitral regurgitation (MR) negatively affects prognosis in acutely decompensated heart failure (ADHF), but can be rapidly sensitive to changes in volume status and medical interventions. We sought to assess the evolution of secondary MR in patients hospitalized for ADHF and its prognostic implications.

Methods
We retrospectively enrolled 782 patients admitted for ADHF with at least two in-hospital echocardiographic evaluations of MR. We classified MR severity as none-mild or moderate-severe. Based on MR evolution, patients were divided into ‘persistent moderate-severe MR’, ‘improved MR’ (from moderate-severe to none-mild) and ‘persistent none-mild MR’.

Results
Four hundred and forty patients (56%) had moderate-severe MR at first evaluation, of whom 144 (33% of patients with baseline moderate-severe MR) had ‘improved MR’, while 296 (67%) had ‘persistent moderate-severe MR’. Patients with improved MR had better clinical, laboratory and echocardiographic parameters of decongestion at discharge compared with those with persistent moderate-severe MR and showed a higher up-titration of recommended therapies. Left ventricular volume, ejection fraction and serum urea were the predictors of improved MR at multivariable analysis. After adjustment, no differences in 5-years survival (primary outcome) were observed according to baseline MR severity. When patients were stratified according to the in-hospital changes in MR severity, improved MR was associated with lower risk of 5-years mortality, compared with both persistent none-mild MR [hazard ratio (HR) = 0.505, P = 0.032] and persistent moderate-severe MR (HR = 0.556, P = 0.040).

Conclusions
The severity of MR frequently improved during hospitalization for ADHF; the extent and the changes in MR severity during the in-hospital stay identified distinct patient phenotypes, and seemed to portend different long-term outcomes, with higher 5-years survival associated with improvement in MR.
The prevalence of ER-low-positive breast cancer and its relation to tumor characteristics in Syria
Authors: Asaad Remal Abdulaziz , Sudan Hla , Hasan Bailasan , Abdullah Siraj Saadaldin 
Published: September 2024

Abstract
Background: Breast cancer is a heterogeneous disease with varying clinical behaviors and responses to endocrine therapy. In particular, estrogen receptor (ER)-positive breast cancer can present with various subtypes, and the effectiveness of anti-hormone therapy on ER-low-positive tumors is unclear. This study aimed to evaluate and characterize ER-positive subtypes in patients admitted to the Surgical Oncology Clinic in the National Hospital of Jableh in Syria between 2020 and 2022. Patients and Methods: This study included 120 patients diagnosed with breast cancer; the data from each patient’s report were collected to classify them according to grade, stage, LNR, tumor size, and nodal stage. Results: The prevalence of ER-low-positive subtype was 23.33%. There was a significant difference between ER-negative and ER-positive subtypes concerning age, grade, stage, and LNR. Additionally, we confirmed a variation between ER-low-positive and ER-high-positive tumors, which may explain the difference in therapeutic response in ER-positive tumor patients taking anti-ER drugs. Conclusion: Further research is necessary to study the association between therapeutic response and ER-staining intensity breast cancer subtypes.
The Concept of a Method for Predicting the Cascade Effect Under Conditions of Hybrid Warfare
Authors: WRÓBLEWSKI Wojciech , WIŚNIEWSKI Michał 
Published: September 2024

Abstract
The changing nature of conflicts is creating new challenges in civilian protection. Features of hybrid warfare, such as multidimensionality, synergistic effects, blurring of boundaries, or asymmetricity, force practitioners and scholars to consider new threats. The article examines how the characteristics of hybrid warfare affect the emergence of cascade effects. We conducted research on examples of the war in Ukraine and the Israeli-Palestinian war. The concept of a method for predicting the cascade effect under conditions of hybrid war is proposed. The concept involves using the Six Ways to Die method to take areas affecting the health and life of the civilian population and define a network of object dependencies on which proper functioning of the State in these areas depends. Using complementary tools such as process analysis, risk assessment, Petri nets, and Bayesian network in the form of the Critical Infrastructure Security Situational Management methodology, the authors provide a comprehensive solution for modeling how to protect the life and health of the civilian population. To the author’s knowledge, this is the first holistic study in this issue.
Design and Implementation of Low Power and High Data Rate Edge Coded Signaling Architecture for IoT Devices
Authors: Jamuna M , VijayaPrakash A. M 
Published: September 2024

Abstract
Edge coded signaling (ECS) is a recently introduced communication protocol designed for single-channel signaling among constrained internet of things (IoT) nodes. This study aims to enhance the data rate of ECS, without increasing the clock frequency or power consumption. The goal is to develop an improved protocol that maintains the inherent advantages of ECS while achieving a higher data rate. The proposed solution, double data rate ECS (DDR-ECS), leverages both pulse edges of the ECS pulse stream for information encoding, drawing an analogy to DDR memory systems. The study presents a detailed design of low-power architecture for the DDR-ECS transceiver. This design was synthesized using a 65 nm ASIC process to evaluate its performance in terms of power consumption, gate count, and data rate. The synthesis results demonstrate that the DDR-ECS transceiver preserves the key features of ECS, including tolerance to clock frequency variations and compatibility with lightweight cryptographic algorithms. It effectively doubles the dynamic data rate to the range of 12–73.5 Mb/s while consuming an equivalent power of 13 μW and occupying a compact form factor of only 1,755 gates. The introduction of DDR-ECS represents a significant advancement in the ECS protocol, offering a novel approach to doubling the data rate without increasing the clock frequency or power envelope. This innovation retains the simplicity and efficiency of ECS, providing an enhanced communication solution for constrained IoT nodes.
Inkarnationen des Bösen im sozialistischen Denken
Authors: Pfützner Robert 
Published: September 2024

Abstract
From a Western, democratic perspective, the state socialism that existed until 1989 was criticised, not without justification, as an “evil empire” (Reagan). The Gulag, Pol Pot’s mass murders or Ceaușescu’s dictatorship show evident elements of evil in socialism. However, a different perspective is taken in the essay. From an internal hermeneutic perspective, it asks what forms of evil emerged within socialist thought. From a cultural-theoretical point of view, socialism is seen as a belief system and moral framework. Evil appears in this framework as (1) abstract evil, as (2) evil in others, and as (3) evil in oneself. These three figurations will be illuminated.
Die Differenz im Einssein Notizen zur arendtschen „Banalität des Bösen“
Authors: Cioflec Eveline 
Published: September 2024

Abstract
This paper takes up the controversial arendtian term “banality of evil” and shows how plurality rooted in non-indifference is necessary for preventing us from acting bad. Distinct from “radical Evil” the “Banality of Evil” is not in itself banal. Evil deeds sneak into everyday life if being-one with oneself by consulting with oneself on the actions to be taken is missing. Hence, being-one presupposes plurality for the inner dialogue. As a matter of fact, plurality is rooted in the natality of human beings, in being born as being separated and differentiated from others. Nevertheless, conscious plurality as active non-indifference in thought and judgment is yet necessary.
Die deutsche Konjunktur seit 2020 und die strukturelle Schwäche der Industrie
Authors: Hohlfeld Peter , Theobald Thomas 
Published: September 2024

Abstract
The German economy has been suffering from multiple crises in recent years. This is regularly reflected in the outcome of leading economic indicators, such as the monthly “IMK Konjunkturindikator”. Structural developments are difficult to identify in such an environment. However, the German economy’s dominant “business model” for much of the 2000s, which consisted of strong export-led growth, appears to have come under pressure not only in the automotive industry. Rather, competition from China is also being felt in large parts of the machine building and electrical industries. Without a significant increase in public investment in Germany and a consistent European industrial policy, there is little hope that the secondary sector will be able to provide an economic stimulus to overcome the current stagnation in Germany.
The Impact of Magnetic Activated Cell Sorting (MACS) on Assisted Reproduction Outcomes
Authors: Raiheen KP , Kunjimoideen KU , Seethi Feseena , Subhash Vivek V 
Published: September 2024

Objectives
The study’s objectives were to evaluate the benefits of adding the magnetically activated cell sorting (MACS) technique to the traditional density gradient sperm wash method for advanced sperm selection in intracytoplasmic sperm injection (ICSI) cycles by comparing fertilisation rates, embryo quality, blastocyst formation, and pregnancy rates.

Material and Methods
A retrospective observational study was conducted at ARMC Aegis Hospital Perinthalmanna, Kerala. The study group was 116 patients taken during ICSI cycles done from October 2021 to September 2023, with 58 patients in the study (MACS after density gradient centrifugation) and 58 in control (density gradient centrifugation alone). Cases and controls were determined by the willingness of the patient to do MACS in sperm selection after discussion with their clinician. Patients with a severe male factor with sperm morphology <4% were included in the study, with the female partner having regular cycles, normal AFC, and AMH > 1 ng/ml. Patients with seminal infection, known genetic errors, female partners with endometriosis, PCOS, infections, malformations and previous poor responders were excluded. Spermatozoa are incubated with microbeads for 15 min at room temperature (100 μl/10 million) in MACS, after which they are placed into a separation column that contains magnetised iron spheres in it that is magnetised. While the unlabelled cells flow through the MACS column, the micro-bead labelled cells are trapped there subsequently, ICSI was performed using the processed sperm sample. The 2PN (Pro-nuclei) embryos, blastocysts, embryo quality, clinical pregnancies, and live births were noted and statistically analysed.

Results
The study and control groups were demographically similar; both cases (MACS group) and control group Density Gradient Centrifugation (DGC) group were under a 95% confidence interval. Results of the MACS group were compared with the DGC group. 2 PN status, number of embryos, Grade I embryos, day 5 blastocyst formation, live birth rates, and the number of positive pregnancies were examined in both groups. Analysis showed an increase in the 2 PN status, number of embryos, Grade I embryos, and day 5 blastocyst formation in the MACS group compared to the conventional DGC method. However, embryo grades (Grade I embryos) in the MACS group were high compared to the DGC group (P-value < 0.01).

Conclusion
For couples with severe male factors and defective sperm morphology, the study finds that MACS may be recommended as an additional option to standard sperm processing.