bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rogaratinib Plus Atezolizumab in Cisplatin-Ineligible Patients With FGFR RNA-Overexpressing Urothelial Cancer
Authors: Sweis Randy F. , Gajate Pablo , Morales-Barrera Rafael , Lee Jae-Lyun , Necchi Andrea , de Braud Filippo , Penel Nicolas , Grünwald Viktor , Maruzzo Marco , Meran Johannes , Ishida Tatiane Cristine , Bao Weichao , Zhou Yinghui , Ellinghaus Peter , Rosenberg Jonathan E. 
Published: September 2024

ImportanceThe oral pan–fibroblast growth factor receptor inhibitor rogaratinib previously demonstrated encouraging safety and efficacy in a phase 1 study of patients with urothelial cancer (UC) overexpressing FGFR messenger RNA (mRNA).ObjectiveTo evaluate the safety, pharmacokinetics, and preliminary efficacy of rogaratinib in combination with the programmed cell death 1 ligand 1 (PD-L1) inhibitor atezolizumab in cisplatin-ineligible patients with FGFR mRNA-positive, locally advanced/metastatic UC.Design, Setting, and ParticipantsThe FORT-2 nonrandomized clinical trial was an open-label, single-arm, multicenter study conducted between May 15, 2018, and July 16, 2021, in 30 centers across Asia, Europe, and North America. Eligible patients had locally advanced/metastatic UC with FGFR1/3 mRNA overexpression and were ineligible for cisplatin-based chemotherapy. The data analysis was completed from July 2022 to September 2022.InterventionsPatients received rogaratinib 600 mg or rogaratinib 800 mg twice daily in combination with intravenous atezolizumab 1200 mg every 21 days.Main Outcomes and MeasuresPrimary end points included safety, tolerability, and the recommended phase 2 dose (RP2D) of rogaratinib in combination with atezolizumab.ResultsAmong 153 patients screened, 73 (48%) had tumors with FGFR1/3 mRNA overexpression, and 37 patients were enrolled and treated (median [range] age, 75.0 [47.0-85.0] years; 32 [87%] male). The most common treatment-emergent adverse events (TEAEs) included diarrhea in 23 patients (62%), hyperphosphatemia in 19 (51%), and fatigue in 15 (41%). Grade 3 or higher TEAEs were reported in 27 patients (73%), and 4 grade 5 TEAEs were reported, though unrelated to treatment. The RP2D was rogaratinib 600 mg in combination with atezolizumab 1200 mg. At the RP2D, the overall response rate was 53.8% in the rogaratinib 600 mg group, including 4 patients (15%) with complete responses; 12 responders (86%) did not have an FGFR3 gene alteration, and 11 (79%) had low PD-L1 expression.Conclusions and RelevanceIn this phase 1b nonrandomized clinical trial, rogaratinib plus atezolizumab demonstrated a manageable safety profile, with no unexpected safety signals. Efficacy for this combination at the RP2D was observed in tumors with low PD-L1 and was not dependent on FGFR3 gene alterations, suggesting broad potential benefit for patients with locally advanced/metastatic UC and FGFR mRNA overexpression.Trial RegistrationClinicalTrials.gov Identifier: NCT03473756
Potential Gaps in Eye Care Based on Evaluation of Federally Qualified Health Centers
Authors: Yadlapalli Nikhita , Hollinger Ruby , Berzack Shannan , Spies Daniela , Patel Annika , Sridhar Jayanth 
Published: September 2024

ImportanceFederally qualified health centers (FQHCs) are federally funded community health clinics that provide comprehensive care to underserved populations, making them potential opportunities to offer eye care and address unmet health care needs. Evaluating the presence of eye care services at FQHCs in Florida is important in understanding and addressing possible gaps in care for the state’s large uninsured and underserved populations.ObjectiveTo determine whether FQHCs in Florida are currently offering eye care services, where they are available, what services are being offered, and who provides them.Design, Setting, and ParticipantsThis study used a cross-sectional design conducted within 1 year (from November 2023 to February 2024). FQHCs listed in the US Health Resources and Services Administration database were contacted by telephone to inquire about the presence of eye care services. The FQHCs were located in both urban and rural areas in Florida to assess accessibility of eye care services in the state. School-based health centers and nonophthalmic specialty care health centers were excluded. A total of 437 FQHCs were included.Main Outcomes and MeasuresPrimary outcomes included the presence of eye care services, types of services offered, clinician type (optometrists or ophthalmologists), frequency of services, and availability of pediatric services.ResultsAmong 437 FQHCs contacted, only 39 (8.9%) reported offering eye care services. These services primarily included vision examinations, glasses prescriptions, and dilated eye examinations. Optometrists were the primary providers of services at all clinics, with no clinics reporting care by ophthalmologists. The frequency of services varied considerably, ranging from daily to bimonthly. Thirty-seven (94.9%) of the 39 clinics offered pediatric eye care services.Conclusions and RelevanceThe low prevalence of FQHCs with eye care services and the absence of ophthalmologist-provided care highlight a gap in access to eye care for underserved populations in Florida. These findings support investigations into implementing eye care services and interventions at FQHCs that might enhance access and equity in eye care.
Incidence and Risk of Depressive Disorder in Patients With Retinitis Pigmentosa
Authors: Kim Hae Rang , Lee Nang Kyeong , Suh Youngsong , Lee Christopher Seungkyu , Byeon Suk Ho , Kim Sung Soo , Lee Seung Won , Kim Yong Joon 
Published: September 2024

ImportanceThere is a lack of large-scale clinical studies exploring mental health among patients with retinitis pigmentosa (RP). Additionally, few studies have evaluated the associations of visual impairment with mental health in young patients.ObjectiveTo investigate the association between depressive disorder and RP.Design, Setting, and ParticipantsThis was a retrospective, nationwide, population-based cohort study using data obtained from the Health Insurance Review and Assessment service in Korea between 2008 and 2022. A total of 10 879 individuals who were newly diagnosed with RP between January 2011 and December 2021, as verified by both the RP registration code (National Registry of Rare and Intractable Disease in Korea code V209) and diagnostic code (International Statistical Classification of Diseases, 10th Revision code H35.51), were included. Data analysis was performed from October 2023 to January 2024.ExposureDiagnosis of RP.Main Outcomes and MeasuresParticipants were categorized into 3 groups based on age at diagnosis (&amp;lt;20, 20-39, and ≥40 years). The incidence of depressive disorder in RP was determined after excluding those diagnosed with depressive disorder prior to RP diagnosis. Age- and sex-adjusted standardized incidence ratios (SIRs) of depressive disorder in patients with RP compared with the general population were calculated. Subgroup analyses by sex and age group were conducted.ResultsA total of 10 879 patients (638 aged &amp;lt;20 years, 2233 aged 20-39 years, and 8008 aged ≥40 years; 5710 [52.5%] female) newly diagnosed with RP between 2011 and 2021 were included. The 10-year cumulative incidence of depressive disorder was 17.67% (95% CI, 16.57%-18.84%) in patients with RP. Subgroup analysis showed higher incidence of depressive disorder in female patients (hazard ratio [HR], 1.46; 95% CI, 1.29-1.65; P &amp;lt; .001) and those aged 40 years or older (HR, 1.93; 95% CI, 1.63-2.29; P &amp;lt; .001). The overall SIR of depressive disorder in patients with RP was 1.19 (95% CI, 1.12-1.27; P &amp;lt; .001), indicating a higher risk of depressive disorder compared with that in the general population. Both male and female patients with RP showed increased incidence rates of depressive disorder (17.53 [95% CI, 15.91-19.27] and 25.57 [95% CI, 23.58-27.67] per 1000 person-years, respectively) and increased SIRs of depressive disorder (1.21 [95% CI, 1.10-1.33] and 1.18 [95% CI, 1.09-1.28], respectively) (all P &amp;lt; .001) compared with the general population. Subgroup analysis by age group showed that the SIR peaked in patients in their 20s (1.50; 95% CI, 1.17-1.90; P = .006) and aged 60 years or older (1.25; 95% CI, 1.14-1.37; P &amp;lt; .001).Conclusions and RelevanceIndividuals diagnosed with RP had a higher risk of developing depressive disorder. These findings support consideration of providing emotional and social support to patients with RP.
Pressure Visualization and Quantification Photonic Skin Based on Flexible Optical Fiber Combiner
Authors: Fang Jie , Zheng Hongyan , Yang Anping , Liu Haojun , He Yongcheng , Zhou Hongyou , Liu Luyan , Song Enhai , Guo Qianyi , Gan Jiulin , Yang Zhongmin 
Published: September 2024

AbstractThe integration of pressure quantification and visualization enhances pressure perception, accuracy, and efficiency. Current solutions require improvements in quantization accuracy, structural simplicity, and integration. We proposed a novel photonic skin comprising a 3 × 1 flexible optical fiber combiner, integrating red, green, and blue light emitting diode (LED) chips through three flexible optical fibers. Under pressure, changes in the optical fibers' transmission loss alter the output light intensity ratio, thus inducing a color shift at the combiner's output. This visible change can be precisely quantified using a color sensor chip. Performance metrics include sensing range up to 33N, sensitivity between 0.04 and 0.24 dB N−1, detection limit below 0.08 N, response time of 500 ms, recovery time of 400 ms, and durability exceeding 2000 cycles. A compact flexible circuit board manages light source driving, data acquisition, and wireless communication, forming a wearable photonic skin system. This system enables visual recognition and quantitative measurement of pressure across diverse scenarios, including different tactile modes, multi‐position pressure, finger bending, and neck movement. For oral occlusion force detection, the spatial separation of the sensing and visualization areas enables the system to simultaneously provide accurate measurements and intuitive visual assessment.
Qualitative Identification of the Spin‐to‐Orbital Conversion Mechanism Modulated by Rare‐Earth Nd, Gd, and Ho Metals via Terahertz Emission Measurements
Authors: Liu Long , Jiang Tianran , Zhao Xiaotian , Chen Ke , Lai Tianshu , Liu Wei , Zhang Zhidong 
Published: September 2024

AbstractIt is crucial to study the materials that could effectively facilitate the inter‐conversion between charge, spin, and orbital degrees of freedom. In this work, the conversion among these three types of degrees of freedom in Pt/CoFeB/rare‐earth (RE, represents Nd, Gd, and Ho)/Ti multilayers is manipulated. Through terahertz (THz) emission measurements, it is found that the spin current induced by a femtosecond laser is converted into an orbital current via the spin‐orbit coupling of the RE layer. Notably, the light RE (Nd) and heavy RE (Gd and Ho) induce the orbital current with opposite polarization directions, ultimately leading to a weakening or enhancement of the THz emission intensity, respectively. Moreover, the fast Fourier transform reveals that Gd exerts the most significant influence on increasing the whole THz spectrum within the Pt/CoFeB/RE/Ti structure. The findings of RE‐modulated spin‐to‐orbital conversion provide valuable insights into the fundamental transport mechanism of the orbital current.
BOIMPY Scaffold: Accessing Ultrahigh Molar Extinction Coefficient AIEgen for SWIR Imaging‐Guided Photothermal Cancer Ablation
Authors: Yang Mingwang , Ou Xinwen , Zhang Jianyu , Sun Jianwei , Kwok Ryan T. K. , Lam Jacky W. Y. , Fan Jiangli , Tang Ben Zhong 
Published: September 2024

AbstractDespite the extensive reporting of versatile aggregation‐induced emission luminogens (AIEgens), boosting their molar extinction coefficient (MEC, ε ≈ 103–104 M−1cm−1) remains a formidable challenge, which poses a significant obstacle to achieving the ceiling of their output performance. In this work, an “aggrandizing absorption reservoir” approach is proposed to designing AIEgens with remarkable photons‐harvesting ability, ultimately enlarging its output performance in terms of short‐wave infrared (SWIR, 900–1700 nm) emission and photothermal effect. For the first time, the (bis‐(borondifluoride)‐8‐imidazodipyrromethene) (BOIMPY) unit, which provides sufficient rigidity and strong electron‐withdrawing ability by employing benzimidazole as a bridging ligand binding two BF2 units, is utilized to fabricate novel AIEgen (TPEB) that exhibits an ultrahigh MEC up to 1.29 × 105 M−1 cm−1 at 828 nm. To the best of knowledge, this is the highest MEC reported among AIEgens with near‐infrared absorption. Thanks to its remarkable photon‐harvesting ability, TPEB exhibits strong fluorescence in the SWIR region and a good photothermal effect. The as‐prepared TPEB NPs are successfully applied for SWIR imaging‐guided photothermal antitumor therapy. The proposed “aggrandizing absorption reservoir” approach provides a novel guideline for designing versatile AIEgens for biomedical applications.
High Entropy Helps Na4Fe3(PO4)2P2O7 Improve Its Sodium Storage Performance
Authors: Hu Xinyu , Li Houmou , Wang Zhihao , Liu Mingzu , Lu Yongyi , Zhang Yan , Li Jiajun , Ding Kun , Liu Haimei , Ma Zi‐Feng , Wang Yonggang 
Published: September 2024

AbstractRecently, a high‐entropy strategy has attracted extensive attention and is applied to the preparation of electrode materials for energy storage batteries, aiming to improve electrochemical performance. It is found that adjusting the conformational entropy of the material can significantly enhance ion and electron transport efficiency, as well as improve the structural stability of the host material. However, there still remains a lack of deep understanding into the high‐entropy strategy, specifically regarding how this approach can alter the intrinsic properties of the material. In this work, the Na4Fe3(PO4)2P2O7 is designed and prepared as a model material with higher entropy, and ultimately, an optimized sample of Na3.9Fe2.6V0.1Mn0.1Cu0.1Mg0.1(PO4)2(P2O7) is achieved. The results indicate that increasing the entropy value of the material notably enhances its crystal structure, diffusion kinetics, and interfacial stability. Consequently, this optimized sample demonstrates deep insertion/extraction of 2.8 Na+, yielding an impressively high capacity of 122.3 mAh g−1 at 0.1C, alongside an ultra‐high rate capability of 100C. Remarkably, it also sustains performance over 14 000 cycles at 50C. This study underscores a method for fabricating high‐performance electrode materials through the implementation of the entropy strategy.
β‐Ga2O3 Nanoribbon with Ultra‐High Solar‐Blind Ultraviolet Polarization Ratio
Authors: Zhao Kai , Yang Juehan , Wang Pan , Zhou Ziqi , Long Haoran , Xin Kaiyao , Liu Can , Han Zheng , Liu Kaihui , Wei Zhongming 
Published: September 2024

AbstractSolar‐blind ultraviolet (UV) detection plays a critical role in imaging and communication due to its low‐noise background, high signal‐to‐noise ratio, and strong anti‐interference capabilities. Detecting the polarization state of UV light can enhance image information and expand the communication dimension. Although polarization detection is explored in visible and infrared light, and applied in fields such as astrophysics and submarine seismic wave detection, solar‐blind UV polarization detection remains largely unreported. This is primarily due to the challenge of creating UV polarizers with high transmittance, high extinction ratio, and strong resistance to UV radiation. In this study, it is discovered that the space symmetry breaking of the β‐Ga2O3’s b–c plane results in a significant optical absorption dichroic ratio. Leveraging β‐Ga2O3’s high solar‐blind UV response, a lensless solar‐blind UV polarization‐sensitive photodetector, circumventing the challenges associated with solar‐blind UV polarizers is designed. This photodetector exhibits an exceptionally high intrinsic polarization ratio under 254 nm linearly polarized light, approximately two orders of magnitude higher than other reported nanomaterial‐based polarization‐sensitive photodetectors. Additionally, it demonstrates significant advantages in solar‐blind UV imaging and light communication. This work introduces a novel strategy for solar‐blind ultraviolet polarization detection and offers a promising approach for solar‐blind light communication.
Spectral Analysis on Color Detection Sharpness of Animal Vision toward Polychromatic Vision System
Authors: Lee Suyeon , Kim Hyochul , Kim Goohwan , Son Hyungbin , Kim Un Jeong 
Published: September 2024

AbstractSpectral discrimination by animal visions such as human, bird, and butterfly is numerically compared by angular analysis of photo‐response (PR) which will be recorded at photo‐receptors. Hyperspectral imaging system is utilized to simulate various animal vision. Bird vision is acute to discriminate colors among different vegetables due to its evenly spaced and narrow spectral responsivity of photo‐receptors compared to that of human. Butterfly vision is excellent in discriminating red tomato ripening due to the exclusive photo‐receptors detecting only over 600 nm. Even real and fake fruits in the same perceived color for human is discriminated by bird vision. Artificial vision with finely resolved polychromatic artificial cone cells are demonstrated surpassing human vision using visible multispectral camera. This provides insights on designing novel bio‐inspired vision system.
Correlated evolution of dispersal traits and habitat preference in the melicgrasses
Authors: Brightly William H. , Bedoya Ana M. , Carlson McKenzie M. , Rottersman Maria G. , Strömberg Caroline A. E. 
Published: September 2024

AbstractPremiseSeed dispersal is a critical process impacting individual plants and their communities. Plants have evolved numerous strategies and structures to disperse their seeds, but the evolutionary drivers of this diversity remain poorly understood in most lineages. We tested the hypothesis that the evolution of wind dispersal traits within the melicgrasses (Poaceae: Meliceae Link ex Endl.) was correlated with occupation of open and disturbed habitats.MethodsTo evaluate wind dispersal potential, we collected seed dispersal structures (diaspores) from 24 melicgrass species and measured falling velocity and estimated dispersal distances. Species’ affinity for open and disturbed habitats were recorded using georeferenced occurrence records and land cover maps. To test whether habitat preference and dispersal traits were correlated, we used phylogenetically informed multilevel models.ResultsMelicgrasses display several distinct morphologies associated with wind dispersal, suggesting likely convergence. Open habitat taxa had slower‐falling diaspores, consistent with increased wind dispersal potential. However, their shorter stature meant that dispersal distances, at a given wind speed, were not higher than those of their forest‐occupying relatives. Species with affinities for disturbed sites had slower‐falling diaspores and greater wind dispersal distances, largely explained by lighter diaspores.ConclusionsOur results are consistent with the hypothesized evolutionary relationship between habitat preference and dispersal strategy. However, phylogenetic inertia and other plant functions (e.g., water conservation) likely shaped dispersal trait evolution in melicgrasses. It remains unclear if dispersal trait changes were precipitated by or predated changing habitat preferences. Nevertheless, our study provides promising results and a framework for disentangling dispersal strategy evolution.
Anchoring Catalytic Metal Nodes within a Single‐Crystalline Pyrazolate Metal‐Organic Framework for Efficient Heterogeneous Catalysis
Authors: Liang Rong‐Ran , Liu Zhaoyi , Han Zongsu , Yang Yihao , Rushlow Joshua , Zhou Hong‐Cai 
Published: September 2024

AbstractThe synthesis of single‐crystalline and robust pyrazolate metal–organic frameworks (Pz‐MOFs) capable of facilitating challenging organic transformations is fundamentally significant in catalysis. Here we demonstrate a metal‐node‐based catalytic site anchoring strategy by synthesizing a single‐crystalline and robust Pz‐MOF (PCN‐1004). PCN‐1004 features one‐dimensional (1D) copper‐Pz chains interconnected by well‐organized ligands, forming a porous three‐dimensional (3D) network with two types of 1D open channels. Notably, PCN‐1004 displays exceptional stability in aqueous solutions across a broad pH range (1 to 14), attributed to the robust copper‐Pz coordination bond. Significantly, PCN‐1004 functions as an outstanding catalyst in cross dehydrogenative coupling reactions for constructing C−O/C−S bonds, even in the absence of directing groups, achieving yields of up to ~99 %, with long cycle lives and high substrate compatibility. PCN‐1004 outperforms all previously reported porphyrin‐based homogeneous and heterogeneous catalysts. Control experiments and computations elucidate the pivotal catalytic role of the copper‐Pz chains and reveal a free radical pathway for the reaction. This work not only demonstrates the successful implementation of a metal‐node‐based catalytic site anchoring strategy for the efficient catalysis of challenging organic transformations but also highlights the synergistic effect of a robust framework, 1D open channels, and active sites in enhancing catalytic efficiency within MOFs.
Multi‐Stage Optimization of Pore Size and Shape in Pore‐Space‐Partitioned Metal–Organic Frameworks for Highly Selective and Sensitive Benzene Capture
Authors: Chen Yichong , Wang Wei , Alston Samuel , Xiao Yuchen , Ajayan Pooja , Bu Xianhui , Feng Pingyun 
Published: September 2024

AbstractCompared to exploratory development of new structure types, pushing the limits of isoreticular synthesis on a high‐performance MOF platform may have higher probability of achieving targeted properties. Multi‐modular MOF platforms could offer even more opportunities by expanding the scope of isoreticular chemistry. However, navigating isoreticular chemistry towards best properties on a multi‐modular platform is challenging due to multiple interconnected pathways. Here on the multi‐modular pacs (partitioned acs) platform, we demonstrate accessibility to a new regime of pore geometry using two independently adjustable modules (framework‐forming module 1 and pore‐partitioning module 2). A series of new pacs materials have been made. Benzene/cyclohexane selectivity is tuned, progressively, from 4.5 to 15.6 to 195.4 and to 482.5 by pushing the boundary of the pacs platform towards the smallest modules known so far. The exceptional stability of these materials in retaining both porosity and single crystallinity enables single‐crystal diffraction studies of different crystal forms (as‐synthesized, activated, guest‐loaded) that help reveal the mechanistic aspects of adsorption in pacs materials.