bluuebunny/crossref_metadata_2025_split huggingface dataset:
Borg's Periodicity Theorems for First-Order Self-Adjoint Systems with Complex Potentials
Authors: Currie Sonja , Roth Thomas T. , Watson Bruce A. 
Published: December 2016

AbstractA self-adjoint first-order system with Hermitian π-periodic potential Q(z), integrable on compact sets, is considered. It is shown that all zeros of are double zeros if and only if this self-adjoint system is unitarily equivalent to one in which Q(z) is π/2-periodic. Furthermore, the zeros of are all double zeros if and only if the associated self-adjoint system is unitarily equivalent to one in which Q(z) = σ2Q(z)σ2. Here, Δ denotes the discriminant of the system and σ0, σ2 are Pauli matrices. Finally, it is shown that all instability intervals vanish if and only if Q = rσ0 + qσ2, for some real-valued π-periodic functions r and q integrable on compact sets.
Junctional tachycardia in a child with non-rheumatic fever streptococcal pharyngitis
Authors: Bansal Neha , Karpawich Peter P. , Sriram Chenni S. 
Published: December 2016

AbstractAccelerated junctional rhythm has been reported in children in the setting of acute rheumatic fever; however, we describe a hitherto unreported case of isolated junctional tachycardia in a child with streptococcal pharyngitis, not meeting revised Jones criteria for rheumatic fever. A previously healthy, 9-year-old girl presented to the emergency department with complaints of sore throat, low-grade fever, and intermittent chest pain. She was found to have a positive rapid streptococcal antigen test. The initial electrocardiogram showed junctional tachycardia with atrioventricular dissociation in addition to prolonged and aberrant atrioventricular conduction. An echocardiogram revealed normal cardiac anatomy with normal biventricular function. The patient responded to treatment with amoxicillin for streptococcal pharyngitis. The junctional tachycardia and other electrocardiogram abnormalities resolved during follow-up.
Study sponsorship and the nutrition research agenda: analysis of randomized controlled trials included in systematic reviews of nutrition interventions to address obesity
Authors: Fabbri Alice , Chartres Nicholas , Scrinis Gyorgy , Bero Lisa A 
Published: December 2016

AbstractObjectiveTo categorize the research topics covered by a sample of randomized controlled trials (RCT) included in systematic reviews of nutrition interventions to address obesity; to describe their funding sources; and to explore the association between funding sources and nutrition research topics.DesignCross-sectional study.SubjectsRCT included in Cochrane Reviews of nutrition interventions to address obesity and/or overweight.ResultsTwo hundred and thirteen RCT from seventeen Cochrane Reviews were included. Funding source and authors’ conflicts of interest were disclosed in 82·6 and 29·6 % of the studies, respectively. RCT were more likely to test an intervention to manipulate nutrients in the context of reduced energy intake (44·2 % of studies) than food-level (11·3 %) and dietary pattern-level (0·9 %) interventions. Most of the food industry-sponsored studies focused on interventions involving manipulations of specific nutrients (66·7 %). Only 33·1 % of the industry-funded studies addressed dietary behaviours compared with 66·9 % of the non-industry-funded ones (P=0·002). The level of food processing was poorly considered across all funding sources.ConclusionsThe predominance of RCT examining nutrient-specific questions could limit the public health relevance of rigorous evidence available for systematic reviews and dietary guidelines.
The website-based eaTracker®‘My Goals’ feature: a qualitative evaluation
Authors: Lieffers Jessica RL , Haresign Helen , Mehling Christine , Arocha Jose F , Hanning Rhona M 
Published: December 2016

AbstractObjectiveIn 2011, Dietitians of Canada added ‘My Goals’ to its website-based nutrition/activity tracking program (eaTracker®,http://www.eaTracker.ca/); this feature allows users to choose ‘ready-made’ or ‘write-your-own’ goals and to self-report progress. The purpose of the present study was to document experiences and perceptions of goal setting and My Goals, and report users’ feedback on what is needed in future website-based goal setting/tracking tools.DesignOne-on-one semi-structured interviews were conducted with (i) My Goals users and (ii) dietitians providing a public information support service, EatRight Ontario (ERO).SettingMy Goals users from Ontario and Alberta, Canada were recruited via an eaTracker website pop-up box; ERO dietitians working in Ontario, Canada were recruited via ERO.SubjectsMy Goals users (n23; age 19–70 years; 91 % female;n5 from Alberta/n18 from Ontario) and ERO dietitians (n5).ResultsDietitians and users felt goal setting for nutrition (and activity) behaviour change was both a beneficial and a challenging process. Dietitians were concerned about users setting poor-quality goals and users felt it was difficult to stick to their goals. Both users and dietitians were enthusiastic about the My Goals concept, but felt the current feature had limitations that affected use. Dietitians and users provided suggestions to improve My Goals (e.g. more prominent presence of My Goals in eaTracker; assistance with goal setting; automated personalized feedback).ConclusionsDietitians and users shared similar perspectives on the My Goals feature and both felt goal use was challenging. Several suggestions were provided to enhance My Goals that are relevant to website-based goal setting/tracking tool design in general.
Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
Authors: Colombo Miriam , Fiandra Luisa , Alessio Giulia , Mazzucchelli Serena , Nebuloni Manuela , De Palma Clara , Kantner Karsten , Pelaz Beatriz , Rotem Rany , Corsi Fabio , Parak Wolfgang J. , Prosperi Davide 
Published: December 2016

AbstractActive targeting of nanoparticles to tumours can be achieved by conjugation with specific antibodies. Specific active targeting of the HER2 receptor is demonstrated in vitro and in vivo with a subcutaneous MCF-7 breast cancer mouse model with trastuzumab-functionalized gold nanoparticles. The number of attached antibodies per nanoparticle was precisely controlled in a way that each nanoparticle was conjugated with either exactly one or exactly two antibodies. As expected, in vitro we found a moderate increase in targeting efficiency of nanoparticles with two instead of just one antibody attached per nanoparticle. However, the in vivo data demonstrate that best effect is obtained for nanoparticles with only exactly one antibody. There is indication that this is based on a size-related effect. These results highlight the importance of precisely controlling the ligand density on the nanoparticle surface for optimizing active targeting, and that less antibodies can exhibit more effect.
A Mott insulator continuously connected to iron pnictide superconductors
Authors: Song Yu , Yamani Zahra , Cao Chongde , Li Yu , Zhang Chenglin , Chen Justin S. , Huang Qingzhen , Wu Hui , Tao Jing , Zhu Yimei , Tian Wei , Chi Songxue , Cao Huibo , Huang Yao-Bo , Dantz Marcus , Schmitt Thorsten , Yu Rong , Nevidomskyy Andriy H. , Morosan Emilia , Si Qimiao , Dai Pengcheng 
Published: December 2016

AbstractIron-based superconductivity develops near an antiferromagnetic order and out of a bad-metal normal state, which has been interpreted as originating from a proximate Mott transition. Whether an actual Mott insulator can be realized in the phase diagram of the iron pnictides remains an open question. Here we use transport, transmission electron microscopy, X-ray absorption spectroscopy, resonant inelastic X-ray scattering and neutron scattering to demonstrate that NaFe1−xCuxAs near x≈0.5 exhibits real space Fe and Cu ordering, and are antiferromagnetic insulators with the insulating behaviour persisting above the Néel temperature, indicative of a Mott insulator. On decreasing x from 0.5, the antiferromagnetic-ordered moment continuously decreases, yielding to superconductivity ∼x=0.05. Our discovery of a Mott-insulating state in NaFe1−xCuxAs thus makes it the only known Fe-based material, in which superconductivity can be smoothly connected to the Mott-insulating state, highlighting the important role of electron correlations in the high-Tc superconductivity.
Clinical Implementation of Integrated Genomic Profiling in Patients with Advanced Cancers
Authors: Borad Mitesh J. , Egan Jan B. , Condjella Rachel M. , Liang Winnie S. , Fonseca Rafael , Ritacca Nicole R. , McCullough Ann E. , Barrett Michael T. , Hunt Katherine S. , Champion Mia D. , Patel Maitray D. , Young Scott W. , Silva Alvin C. , Ho Thai H. , Halfdanarson Thorvardur R. , McWilliams Robert R. , Lazaridis Konstantinos N. , Ramanathan Ramesh K. , Baker Angela , Aldrich Jessica , Kurdoglu Ahmet , Izatt Tyler , Christoforides Alexis , Cherni Irene , Nasser Sara , Reiman Rebecca , Cuyugan Lori , McDonald Jacquelyn , Adkins Jonathan , Mastrian Stephen D. , Valdez Riccardo , Jaroszewski Dawn E. , Von Hoff Daniel D. , Craig David W. , Stewart A. Keith , Carpten John D. , Bryce Alan H. 
Published: December 2016

AbstractDNA focused panel sequencing has been rapidly adopted to assess therapeutic targets in advanced/refractory cancer. Integrated Genomic Profiling (IGP) utilising DNA/RNA with tumour/normal comparisons in a Clinical Laboratory Improvement Amendments (CLIA) compliant setting enables a single assay to provide: therapeutic target prioritisation, novel target discovery/application and comprehensive germline assessment. A prospective study in 35 advanced/refractory cancer patients was conducted using CLIA-compliant IGP. Feasibility was assessed by estimating time to results (TTR), prioritising/assigning putative therapeutic targets, assessing drug access, ascertaining germline alterations, and assessing patient preferences/perspectives on data use/reporting. Therapeutic targets were identified using biointelligence/pathway analyses and interpreted by a Genomic Tumour Board. Seventy-five percent of cases harboured 1–3 therapeutically targetable mutations/case (median 79 mutations of potential functional significance/case). Median time to CLIA-validated results was 116 days with CLIA-validation of targets achieved in 21/22 patients. IGP directed treatment was instituted in 13 patients utilising on/off label FDA approved drugs (n = 9), clinical trials (n = 3) and single patient IND (n = 1). Preliminary clinical efficacy was noted in five patients (two partial response, three stable disease). Although barriers to broader application exist, including the need for wider availability of therapies, IGP in a CLIA-framework is feasible and valuable in selection/prioritisation of anti-cancer therapeutic targets.
The emergence of waves in random discrete systems
Authors: Pickton John , Hopcraft Keith Iain , Jakeman Eric 
Published: December 2016

AbstractEssential criteria for the emergence of wave-like manifestations occurring in an entirely discrete system are identified using a simple model for the movement of particles through a network. The dynamics are entirely stochastic and memoryless involving a birth-death-migration process. The requirements are that the network should have at least three nodes, that migration should have a directional bias, and that the particle dynamics have a non-local dependence. Well defined bifurcations mark transitions between amorphous, wave-like and collapsed states with an intermittent regime between the latter two.
Model of electrical activity in cardiac tissue under electromagnetic induction
Authors: Wu Fuqiang , Wang Chunni , Xu Ying , Ma Jun 
Published: December 2016

AbstractComplex electrical activities in cardiac tissue can set up time-varying electromagnetic field. Magnetic flux is introduced into the Fitzhugh-Nagumo model to describe the effect of electromagnetic induction, and then memristor is used to realize the feedback of magnetic flux on the membrane potential in cardiac tissue. It is found that a spiral wave can be triggered and developed by setting specific initials in the media, that is to say, the media still support the survival of standing spiral waves under electromagnetic induction. Furthermore, electromagnetic radiation is considered on this model as external stimuli, it is found that spiral waves encounter breakup and turbulent electrical activities are observed, and it can give guidance to understand the occurrence of sudden heart disorder subjected to heavily electromagnetic radiation.
Gene expression profiles and physiological data from mice fed resveratrol-enriched rice DJ526
Authors: Chung Hea-Jong , Lee Heui-Kwan , Kim Hyeon-Jin , Baek So-Hyeon , Hong Seong-Tshool 
Published: December 2016

AbstractThe molecular mechanism underlying lifespan extension by resveratrol remains widely discussed. To help study this mechanism, we previously created resveratrol-enriched rice, DJ526, by transferring the resveratrol biosynthesis gene into Dongjin rice. DJ526 accumulates 1.4–1.9 μg g−1 of resveratrol in its grain and can ameliorates age-related deterioration in mice, as compared to control animals, based on assessments of motor coordination, physical strength and cutaneous tissue aging. Here, we present raw data sets, deposited in public repositories, from microarray analysis and physiological data of mice fed with DJ526 and Dongjin rice and treated with resveratrol. We also provide a method to analyze blood serum at micron levels. These data sets may help other researchers find new clues regarding the etiology of the anti-aging process and signaling pathways induced by resveratrol, rice, or DJ526.
Multi-echo fMRI replication sample of autobiographical memory, prospection and theory of mind reasoning tasks
Authors: DuPre Elizabeth , Luh Wen-Ming , Spreng R. Nathan 
Published: December 2016

AbstractThe default network is involved in self-generated thought, a class of cognition that includes autobiographical memory, prospection, and reasoning about the mental states of others. We collected a replication sample of Spreng and Grady (J Cogn. Neurosci. 22, 1112–1123, 2010), confirming that the default network differentially supports each of these forms of self-generated thought. Here we describe this dataset of multi-echo fMRI data in 31 young adults during autobiographical remembering, imagining, and mentalizing; we also provide an additional resting-state scan for each subject. In this new sample, the findings from the original report are successfully replicated using the same analysis. Physiological measures were additionally collected and allow for interrogation of the impact of multi-echo independent components preprocessing both in task and rest. Future work on this dataset may provide insight into evoked brain response for cued self-generated thought, International Affective Picture System viewing, resting state dynamics, preprocessing procedures, and more. The dataset is accompanied by experimental code for independent behavioral data collection.
Remotely sensed high resolution irrigated area mapping in India for 2000 to 2015
Authors: Ambika Anukesh Krishnankutty , Wardlow Brian , Mishra Vimal 
Published: December 2016

AbstractIndia is among the countries that uses a significant fraction of available water for irrigation. Irrigated area in India has increased substantially after the Green revolution and both surface and groundwater have been extensively used. Under warming climate projections, irrigation frequency may increase leading to increased irrigation water demands. Water resources planning and management in agriculture need spatially-explicit irrigated area information for different crops and different crop growing seasons. However, annual, high-resolution irrigated area maps for India for an extended historical record that can be used for water resources planning and management are unavailable. Using 250 m normalized difference vegetation index (NDVI) data from Moderate Resolution Imaging Spectroradiometer (MODIS) and 56 m land use/land cover data, high-resolution irrigated area maps are developed for all the agroecological zones in India for the period of 2000–2015. The irrigated area maps were evaluated using the agricultural statistics data from ground surveys and were compared with the previously developed irrigation maps. High resolution (250 m) irrigated area maps showed satisfactory accuracy (R2=0.95) and can be used to understand interannual variability in irrigated area at various spatial scales.
Metagenomic mining for thermostable esterolytic enzymes uncovers a new family of bacterial esterases
Authors: Zarafeta Dimitra , Moschidi Danai , Ladoukakis Efthymios , Gavrilov Sergey , Chrysina Evangelia D. , Chatziioannou Aristotelis , Kublanov Ilya , Skretas Georgios , Kolisis Fragiskos N. 
Published: December 2016

AbstractBiocatalysts exerting activity against ester bonds have a broad range of applications in modern biotechnology. Here, we have identified a new esterolytic enzyme by screening a metagenomic sample collected from a hot spring in Kamchatka, Russia. Biochemical characterization of the new esterase, termed EstDZ2, revealed that it is highly active against medium chain fatty acid esters at temperatures between 25 and 60 °C and at pH values 7–8. The new enzyme is moderately thermostable with a half-life of more than six hours at 60 °C, but exhibits exquisite stability against high concentrations of organic solvents. Phylogenetic analysis indicated that EstDZ2 is likely an Acetothermia enzyme that belongs to a new family of bacterial esterases, for which we propose the index XV. One distinctive feature of this new family, is the presence of a conserved GHSAG catalytic motif. Multiple sequence alignment, coupled with computational modelling of the three-dimensional structure of EstDZ2, revealed that the enzyme lacks the largest part of the “cap” domain, whose extended structure is characteristic for the closely related Family IV esterases. Thus, EstDZ2 appears to be distinct from known related esterolytic enzymes, both in terms of sequence characteristics, as well as in terms of three-dimensional structure.
Putative WRKYs associated with regulation of fruit ripening revealed by detailed expression analysis of the WRKY gene family in pepper
Authors: Cheng Yuan , JalalAhammed Golam , Yu Jiahong , Yao Zhuping , Ruan Meiying , Ye Qingjing , Li Zhimiao , Wang Rongqing , Feng Kun , Zhou Guozhi , Yang Yuejian , Diao Weiping , Wan Hongjian 
Published: December 2016

AbstractWRKY transcription factors play important roles in plant development and stress responses. Here, global expression patterns of pepper CaWRKYs in various tissues as well as response to environmental stresses and plant hormones were systematically analyzed, with an emphasis on fruit ripening. The results showed that most CaWRKYs were expressed in at least two of the tissues tested. Group I, a subfamily of the entire CaWRKY gene family, had a higher expression level in vegetative tissues, whereas groups IIa and III showed relatively lower expression levels. Comparative analysis showed that the constitutively highly expressed WRKY genes were conserved in tomato and pepper, suggesting potential functional similarities. Among the identified 61 CaWRKYs, almost 60% were expressed during pepper fruit maturation, and the group I genes were in higher proportion during the ripening process, indicating an as-yet unknown function of group I in the fruit maturation process. Further analysis suggested that many CaWRKYs expressed during fruit ripening were also regulated by abiotic stresses or plant hormones, indicating that these CaWRKYs play roles in the stress-related signaling pathways during fruit ripening. This study provides new insights to the current research on CaWRKY and contributes to our knowledge about the global regulatory network in pepper fruit ripening.
Bacterial cytosolic proteins with a high capacity for Cu(I) that protect against copper toxicity
Authors: Vita Nicolas , Landolfi Gianpiero , Baslé Arnaud , Platsaki Semeli , Lee Jaeick , Waldron Kevin J. , Dennison Christopher 
Published: December 2016

AbstractBacteria are thought to avoid using the essential metal ion copper in their cytosol due to its toxicity. Herein we characterize Csp3, the cytosolic member of a new family of bacterial copper storage proteins from Methylosinus trichosporium OB3b and Bacillus subtilis. These tetrameric proteins possess a large number of Cys residues that point into the cores of their four-helix bundle monomers. The Csp3 tetramers can bind a maximum of approximately 80 Cu(I) ions, mainly via thiolate groups, with average affinities in the (1–2) × 1017 M−1 range. Cu(I) removal from these Csp3s by higher affinity potential physiological partners and small-molecule ligands is very slow, which is unexpected for a metal-storage protein. In vivo data demonstrate that Csp3s prevent toxicity caused by the presence of excess copper. Furthermore, bacteria expressing Csp3 accumulate copper and are able to safely maintain large quantities of this metal ion in their cytosol. This suggests a requirement for storing copper in this compartment of Csp3-producing bacteria.
The biosynthetic pathway of 2-azahypoxanthine in fairy-ring forming fungus
Authors: Suzuki Tomohiro , Yamamoto Naoki , Choi Jae-Hoon , Takano Tomoyuki , Sasaki Yohei , Terashima Yurika , Ito Akinobu , Dohra Hideo , Hirai Hirofumi , Nakamura Yukino , Yano Kentaro , Kawagishi Hirokazu 
Published: December 2016

Abstract“Fairy rings” resulting from fungus-stimulated plant growth occur all over the world. In 2010, 2-azahypoxanthine (AHX) from a fungus Lepista sordida was identified as the “fairy” that stimulates plant growth. Furthermore, 2-aza-8-oxohypoxanthine (AOH) was isolated as a common metabolite of AHX in plants, and the endogenous existence of AHX and AOH in plants was proved. The structure of AHX allowed us to hypothesize that AHX was derived from 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR). Thus, we performed a feeding experiment that supplied AICAR to L. sordida. Consumption of AICAR and accumulation of AHX were observed after feeding. The mycelia extract had enzymatic activity of adenine/5-aminoimidazole-4-carboxamide phosphoribosyltransferase (APRT). APRT gene of L. sordida revealed its structural characteristics in homology modeling and showed transcriptional enhancement after feeding. These results support that AHX was synthesized from AICAR and AHX biosynthesis was transcriptionally controlled by AICAR, indicating the presence of novel purine metabolic pathway in L. sordida.
Redox properties of extracellular polymeric substances (EPS) from electroactive bacteria
Authors: Li Shan-Wei , Sheng Guo-Ping , Cheng Yuan-Yuan , Yu Han-Qing 
Published: December 2016

AbstractAlthough the capacity for electroactive bacteria to convert environmental metallic minerals and organic pollutants is well known, the role of the redox properties of microbial extracellular polymeric substances (EPS) in this process is poorly understood. In this work, the redox properties of EPS from two widely present electroactive bacterial strains (Shewanella oneidensis and Pseudomonas putida) were explored. Electrochemical analysis demonstrates that the EPS extracted from the two strains exhibited redox properties. Spectroelectrochemical and protein electrophoresis analyses indicate that the extracted EPS from S. oneidensis and P. putida contained heme-binding proteins, which were identified as the possible redox components in the EPS. The results of heme-mediated behavior of EPS may provide an insight into the important roles of EPS in electroactive bacteria to maximize their redox capability for biogeochemical cycling, environmental bioremediation and wastewater treatment.