bluuebunny/crossref_metadata_2025_split huggingface dataset:
An assessment of the microbiological quality of lightly cooked food (including sous-vide) at the point of consumption in England
Authors: JØRGENSEN F. , SADLER-REEVES L. , SHORE J. , AIRD H. , ELVISS N. , FOX A. , KAYE M. , WILLIS C. , AMAR C. , DE PINNA E. , MCLAUCHLIN J. 
Published: February 2017

SUMMARYThis observational study aims to investigate the microbiological quality of commercially prepared lightly cooked foods with a major component of food of animal origin and collected as would be served to a consumer. A total of 356 samples were collected from catering (92%), retail (7%) or producers (1%) and all were independent of known incidents of foodborne illness. Using standard methods, all samples were tested for: the presence of Campylobacter spp. and Salmonella spp. and enumerated for levels of, Bacillus spp. including B. cereus, Clostridium perfringens, Listeria spp. including L. monocytogenes, Staphylococcus aureus, Escherichia coli, Enterobacteriacea and aerobic colony count (ACC). Results were interpreted as unsatisfactory, borderline or satisfactory according to the Health Protection Agency guidelines for assessing the microbiological safety of ready-to-eat foods placed on the market. Amongst all samples, 70% were classified as satisfactory, 18% were borderline and 12% were of unsatisfactory microbiological quality. Amongst the unsatisfactory samples, six (2%) were potentially injurious to health due to the presence of: Salmonella spp. (one duck breast); Campylobacter spp. (two duck breast and one chicken liver pâté); L. monocytogenes at 4·3 × 103 cfu (colony-forming units)/g (one duck confit with foie gras ballotin) and C. perfringens at 2·5 × 105 cfu/g (one chicken liver pâté). The remaining unsatisfactory samples were due to high levels of indicator E. coli, Enterobacteriaceae or ACC.
Addressing biophysical constraints for Australian farmers applying low rates of composted dairy waste to soil
Authors: Hayes R. C. , McCormick J. I. , Oates A. A. , Poile G. J. , Conyers M. K. , Gardner M. J. , Price A. , O'Keeffe P. , Li G. D. 
Published: February 2017

AbstractThis study examined the response of forage crops to composted dairy waste (compost) applied at low rates and investigated effects on soil health. The evenness of spreading compost by commercial machinery was also assessed. An experiment was established on a commercial dairy farm with target rates of compost up to 5 t ha−1applied to a field containing millet [Echinochloa esculenta(A. Braun) H. Scholz] and Pasja leafy turnip (Brassicahybrid). A pot experiment was also conducted to monitor the response of a legume forage crop (vetch;Vicia sativaL.) on three soils with equivalent rates of compost up to 20 t ha−1with and without ‘additive blends’ comprising gypsum, lime or other soil treatments. Few significant increases in forage biomass were observed with the application of low rates of compost in either the field or pot experiment. In the field experiment, compost had little impact on crop herbage mineral composition, soil chemical attributes or soil fungal and bacterial biomass. However, small but significant increases were observed in gravimetric water content resulting in up to 22.4 mm of additional plant available water calculated in the surface 0.45 m of soil, 2 years after compost was applied in the field at 6 t ha−1dried (7.2 t ha−1undried), compared with the nil control. In the pot experiment, where the soil was homogenized and compost incorporated into the soil prior to sowing, there were significant differences in mineral composition in herbage and in soil. A response in biomass yield to compost was only observed on the sandier and lower fertility soil type, and yields only exceeded that of the conventional fertilizer treatment where rates equivalent to 20 t ha−1were applied. With few yield responses observed, the justification for applying low rates of compost to forage crops and pastures seems uncertain. Our collective experience from the field and the glasshouse suggests that farmers might increase the response to compost by: (i) increasing compost application rates; (ii) applying it prior to sowing a crop; (iii) incorporating the compost into the soil; (iv) applying only to responsive soil types; (v) growing only responsive crops; and (vi) reducing weed burdens in crops following application. Commercial machinery incorporating a centrifugal twin disc mechanism was shown to deliver double the quantity of compost in the area immediately behind the spreader compared with the edges of the spreading swathe. Spatial variability in the delivery of compost could be reduced but not eliminated by increased overlapping, but this might represent a potential 20% increase in spreading costs.
Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site
Authors: Zhai Xin , Wang Xiaoqiang , Wang Jiao , Liu Jin , Zuo Daiying , Jiang Nan , Zeng Tianfang , Yang Xiuxiu , Jing Tongfei , Gong Ping 
Published: February 2017

AbstractAiming at development of potent antitubulin agents targeting colchicine-binding site, a series of novel 5-indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrilederivatives (5a–5v and 7a–7h) were designed based on bioisosterism and hybridization strategies. All these compounds were concisely synthesized via a three-step process and examined against five human cancer cell lines (HT-29, A549, MKN-45, MDA-MB-231 and SMMC-7721) along with a normal human cell (L02) in vitro. A structure-activity relationships (SARs) study was carried out and optimization towards this series of compounds in cellular assay resulted in the discovery of 5k, which displayed similar or better antitumor potency against the tested cancer cells with IC50 value ranging from 0.02 to 1.22 μM superior to CA-4 and Crolibulin. Significantly, a cell cycle study disclosed the ability of 5k to arrest cell cycle at the G2/M phase, and immunofluorescence assay as well as a colchicine competition assay revealed that tubulin polymerization was disturbed by 5k by binding to the colchicine site. Moreover, the molecular modeling mode showed the posture of 5k and Crolibulin was similar in the colchcine-binding pocket of tubulin as identified with the SARs and pharmacological results. Together, all these results rationalized 5k might serve as a promising lead for a novel class of antitubulin agents for cancer treatments.
Increased PKC activity and altered GSK3β/NMDAR function drive behavior cycling in HINT1-deficient mice: bipolarity or opposing forces
Authors: Garzón-Niño Javier , Rodríguez-Muñoz María , Cortés-Montero Elsa , Sánchez-Blázquez Pilar 
Published: February 2017

AbstractMice with histidine triad nucleotide-binding protein 1 (HINT1) deletion exhibit manic-like symptoms that evolve into depressive-like behavior in response to stressful paradigms. Molecular and electrophysiological studies have indicated that HINT1−/− mice exhibit increased PKC, PKA, and GSK3β activities, as well as glutamate N-methyl-D-aspartate receptor (NMDAR)/α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptor (AMPAR) and NR2B/NR2A subunit ratios. Pharmacological interventions stabilized their behavior but through different mechanisms. GSK3β inhibitors and valproate directly attenuated the expression of the manic-like symptoms, whereas PKC inhibition, lamotrigine, or risperidone promoted NMDAR-mediated depressive-like behaviors that counterbalanced the preexisting manic-like symptoms. Naïve HINT1−/− mice exposed to stressful paradigms rapidly manifested depressive-like behaviors in subsequent stressful situations, a capacity that persisted for a couple of weeks thereafter. During the depressive-like phase, citalopram, amitriptyline and MK801 precipitated manic-like behaviors in stressed HINT1−/− mice. Notably, the antagonism of NMDARs prevented HINT1−/− mice from alternating behaviors in response to stress. A comparison with “manic” Black Swiss mice indicated that in HINT1−/− mice, PKC supports manic-like symptoms and reduces the expression of depressive-like behaviors via activation of GSK3β and regulation of NR2B-enriched NMDARs. HINT1−/− mice represent a suitable model for studying human BPD and may facilitate the identification of novel targets and drugs to treat this mental disorder.
Hierarchical self-assembly of squaraine and silica nanoparticle functionalized with cationic coordination sites for near infrared detection of ATP
Authors: Feng Ruizhi , Shi Weining , Wang Dejia , Wen Jia , Li Hongjuan , Sun Shiguo , Xu Yongqian 
Published: February 2017

AbstractOptical activity of hierarchical supramolecular assemblies based on organic dyes would create multiple functional architectures. In this work, three kinds of silica nanoparticles with or without functional groups were synthesized. For the first time, silica nanoparticles can induce positively charged squaraine (SQ) to aggregate to form supramolecular assemblies. Adenosine-5′-triphosphate (ATP) as building blocks was absorbed on the surface of silica nanoparticles through metal-anion coordination and electrostatic interactions, in which the aggregates of SQ was transferred to monomer. The thickness being composed of ATP and SQ on the outside of nanoparticles is about 5 nm. These supramolecular assemblies showed selective turn-on fluorescence response to ATP in near infrared (NIR) region over other ions through metal-anion coordination and electrostatic interactions. These functional silica nanoparticles possessing many advantages provide proof-of-principle “seed crystals” for construction of supramolecular assemblies and platforms for sensing with facile performance.
Computational modeling of in vivo and in vitro protein-DNA interactions by multiple instance learning
Authors: Gao Zhen , Ruan Jianhua 
Published: February 2017

Abstract

Motivation
The study of transcriptional regulation is still difficult yet fundamental in molecular biology research. While the development of both in vivo and in vitro profiling techniques have significantly enhanced our knowledge of transcription factor (TF)-DNA interactions, computational models of TF-DNA interactions are relatively simple and may not reveal sufficient biological insight. In particular, supervised learning based models for TF-DNA interactions attempt to map sequence-level features (k-mers) to binding event but usually ignore the location of k-mers, which can cause data fragmentation and consequently inferior model performance.

Results
Here, we propose a novel algorithm based on the so-called multiple-instance learning (MIL) paradigm. MIL breaks each DNA sequence into multiple overlapping subsequences and models each subsequence separately, therefore implicitly takes into consideration binding site locations, resulting in both higher accuracy and better interpretability of the models. The result from both in vivo and in vitro TF-DNA interaction data show that our approach significantly outperform conventional single-instance learning based algorithms. Importantly, the models learned from in vitro data using our approach can predict in vivo binding with very good accuracy. In addition, the location information obtained by our method provides additional insight for motif finding results from ChIP-Seq data. Finally, our approach can be easily combined with other state-of-the-art TF-DNA interaction modeling methods.

Availability and Implementation
http://www.cs.utsa.edu/∼jruan/MIL/

Supplementary information
Supplementary data are available at Bioinformatics online.
Account ownership and use of financial services among individuals
Authors: Wale Letenah Ejigu , Makina Daniel 
Published: February 2017

Purpose
The purpose of this paper is to understand the effect of individual characteristics (such as sex, age, education and income) on the likelihood of account ownership and use in selected Sub-Saharan African (SSA) economies. Account use is operationalized into two constructs namely the use of account to save and the frequency of account use.

Design/methodology/approach
Data from 18,000 individuals from 18 SSA economies are used for the analysis. These data are sourced from the World Bank’s Global Findex database. Simple probit and selection models are employed as econometric tools.

Findings
Account ownership and use is found to be higher among males, middle aged, high income and educated individuals. The marginal effect of income and education is most pronounced suggesting more policy attention is required in respect of the two factors.

Practical implications
Due to causality issues between financial inclusion and income, addressing the plight of the poor in financial inclusion projects will be a continuing challenge for policy makers.

Originality/value
It supplements the dearth of econometric studies conducted on the topic. Furthermore, regional specific factors affect the generality of results which calls for such type of studies.
Electric appliance advertising: the role of the Good Housekeeping Institute
Authors: Paulson Erika L. , Schramm Mary E. 
Published: February 2017

Purpose
This paper aims to explore how home economists, employed by the Good Housekeeping Institute, may have influenced the use of principles from the home economics movement in advertising appeals for electric appliances.

Design/methodology/approach
A content analysis of more than 400 print advertisements from Good Housekeeping magazine, from 1916 to 1929, was conducted to determine whether manufacturers used appeals derived from the home economics movement in their advertising. Then, the Good Housekeeping Institute’s history is explored to suggest how its relationship with manufacturers may have resulted in the use of the home economics movement’s principles in advertising appeals for electric appliances.

Findings
The content analysis shows that principles of the home economics movement appeared in advertising appeals for electric appliances in advertisements placed in Good Housekeeping magazine during the period studied. Through its unique relationships with electric appliance manufacturers, the Good Housekeeping Institute seems to have taught manufacturers how to position electric appliances by incorporating the principles of the home economics movement in their advertising appeals.

Practical implications
This research demonstrates how a commercial organization successfully navigated its relationships with manufacturers and consumers for mutual benefit.

Originality/value
This work is the first to link the Good Housekeeping Institute’s work with manufacturers to its influence on advertising appeals. This work also expands understanding of the influence of women on marketing practice. Existing literature on women’s publications is also broadened by analyzing Good Housekeeping, rather than the more frequently studied Ladies’ Home Journal.
Paprika Schlesinger
Authors: Hawkins Richard A. 
Published: February 2017

PurposeThis paper explores the development of a luxury retail shoe brand inBelle ÉpoqueVienna.Design/methodology/approachFootwear retailing and marketing history is a neglected area. Unfortunately, no business records have survived from Robert Schlesinger’s shoe stores. However, it has been possible to reconstruct the history of the development of the Paprika Schlesinger brand from its extensive advertising in the Viennese newspaper, theNeue Freie Presse, with the guidance of the founder’s grandson, Prof Robert A. Shaw, Emeritus Professor of Chemistry, Birkbeck, University of London, England. This case study would not have been possible without the digitization of some major collections of primary sources. In 2014, the European Union’sEuropeanadigitization initiative launched a new portal via the Library of Europe website which provides access to selected digitized historic newspaper collections in libraries across Europe. The project partners include the Austrian National Library which has digitized full runs of several major historic Austrian newspapers, including theNeue Freie Presse. Other project partners which have digitized historic newspapers which are relevant to this paper are the Landesbibliothek Dr Friedrich Teßmann of Italy’s Südtirol region, the National Library of France and the Berlin State Library. An associate project partner library, the Slovenian National and University Library’s Digital Library of Slovenia, has also digitized relevant historic newspapers. Furthermore, the City of Vienna has digitized a complete set of Vienna city directories as part of its Wienbibliothek Digital project.FindingsThis paper suggests that Robert Schlesinger created one of the first European luxury retail shoe brands.Originality/valueThis is the first academic study of the historical development of the advertising and marketing of a European luxury retail shoe brand.
The disclosure of environmental conservation costs and its relation to eco-efficiency
Authors: Yook Keun-Hyo , Song Hakjoon , Patten Dennis M. , Kim Il-Woon 
Published: February 2017

PurposeThis paper aims to examine whether the amount of costs disclosed as relating to environmental controls is associated with environmental performance in terms of carbon-based eco-efficiency, and whether any relation supports voluntary disclosure theory or legitimacy theory arguments. Further, this paper attempts to determine whether the relations differ across the initial Kyoto Protocol period.Design/methodology/approachIn this study, the focus was on Japanese firms over the period from 2002 to 2012. Disclosed environmental control costs (capital expenditures and operating costs) were identified and eco-efficiency measures based on carbon emissions were calculated. Relations were tested for using regression models controlling for other potential impact factors.FindingsThis study’s results indicate a negative relation between disclosed levels of environmental control costs and eco-efficiency performance measures, and, for two of our three eco-efficiency metrics, this is more pronounced over the Kyoto Protocol period.Research limitations/implicationsThese results support a legitimacy theory (as opposed to voluntary disclosure theory) explanation for the relation between the levels of disclosed environmental control costs and carbon-based eco-efficiency.Originality/valueThis study is the first to explore how flexibility in cost classification may be used by companies to foster a disclosure strategy.
A new strategic role for purchasing: business partner for value(s) creation
Authors: de Hemmer Gudme Olaf 
Published: February 2017

Purpose
This paper aims to question a new strategic role for purchasers.

Design/methodology/approach
Comparing current hot topics in purchasing with the application of system modeling/value thinking to the purchasing department of a company.

Findings
A new vision of the roles of purchasers arises as creating value(s) for internal stakeholders and suppliers.

Originality/value
The application of system modeling/value management leads to a renewed vision of the company and the purchasers roles.
Framing outcomes of post-diagnostic psychosocial interventions in dementia: the Adaptation-Coping Model and adjusting to change
Authors: Brooker Dawn , Dröes Rose-Marie , Evans Shirley 
Published: February 2017

Purpose
The purpose of this paper is to describe the Adaptation-Coping Model developed by Dröes in the Netherlands to frame the process of optimal adjustment for people diagnosed with dementia. This model is not well-known in English-speaking countries, but appears to have much to offer practitioners and researchers. As part of a large EU research project (MeetingDem) the authors translated and utilised this model in piloting the Dutch Meeting Centre Support Programme in the UK. This is a local community place-based approach to post-diagnostic psychosocial support. It is aimed at people diagnosed with dementia alongside their families and has proven benefits.

Design/methodology/approach
The Adaptation-Coping Model underpins the support provided by the Meeting Centre Programme. The model and its translation into the UK context are described. Focus groups were undertaken with people living with dementia (n=9) and family carers (n=6) at the UK Meeting Centre pilot. Examples from these focus groups are provided in order to illustrate different aspects of the model.

Findings
The translated Adaptation-Coping (adjusting to change) Model provides a way for service users (people with dementia and families) to conceptualise their journey with dementia post-diagnosis, and potentially provides service providers and researchers with aims for treatment and support.

Research limitations/implications
These are initial observations based on a UK pilot service.

Originality/value
Ways of conceptualising psychosocial support for people living with dementia often do not get translated between countries. This model has been successfully utilised within the Netherlands for many years. This paper highlights the opportunity to build on this in English-speaking countries.
Advance Decisions: issues of autonomy, identity and efficacy
Authors: Wilkinson Sue 
Published: February 2017

Purpose
The purpose of this paper is to introduce Advance Decisions, address low uptake and examine fundamental issues that can inform the development of policy and practice in this area.

Design/methodology/approach
This paper discusses findings from a research project with the charity Compassion in Dying (analysing calls to its telephone helpline) and practical experience of working with the charity Advance Decisions Assistance (helping people write Advance Decisions and training healthcare professionals).

Findings
Older people themselves identify the issues of autonomy, identity and efficacy as key challenges in writing Advance Decisions and having them respected.

Originality/value
This paper shows how addressing the “real world” challenges of advance decision making can inform policy and practice.
A Parametric Approach to Estimating Eco‐Efficiency
Authors: Orea Luis , Wall Alan 
Published: February 2017

AbstractThe concept of eco‐efficiency is becoming increasingly popular as a tool to capture economic and environmental aspects of agricultural production. The literature to date has exclusively used the Data Envelopment Analysis (DEA) approach to measure producers’ eco‐efficiency. We show that it can also be estimated using a Stochastic Frontier Analysis (SFA) approach. Our approach not only allows controlling for random noise in the data but also permits an analysis of the potential substitutability between environmental pressures. We provide an empirical application of our model to data on a sample of Spanish dairy farms.
Abrasion Collar Around Shrapnel Entry Wound
Authors: Gujaral Pootheril Balan , Ajay Balachandran 
Published: February 2017

AbstractAbrasion collar is usually described as a feature of bullet entry wounds caused by friction and indentation. The present case is that of the peculiar entry wound caused by a piece of flying shrapnel which was ejected from a furnace in a steel plant. The scrap metal which exploded in the plant was sourced from the West Asia region. The entry wound on the chest was circular and had an abrasion collar around it. The projectile was a cylindrical object of obscure origin. The forensic science laboratory put forth the possibility that the projectile was a component of an artillery fuze. A decades old study which employed high‐speed photography has rejected the possibility that abrasion collars are produced by friction. High‐velocity projectiles other than bullets can also produce abrasion collars as the rubbing of the bullet against the skin or its rotation are not the causative mechanisms.