bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hormonal Regulation of Osteocyte Perilacunar and Canalicular Remodeling in the Hyp Mouse Model of X-Linked Hypophosphatemia
Authors: Tokarz Danielle , Martins Janaina S , Petit Elizabeth T , Lin Charles P , Demay Marie B , Liu Eva S 
Published: October 2017

ABSTRACT

Osteocytes remodel their surrounding perilacunar matrix and canalicular network to maintain skeletal homeostasis. Perilacunar/canalicular remodeling is also thought to play a role in determining bone quality. X-linked hypophosphatemia (XLH) is characterized by elevated serum fibroblast growth factor 23 (FGF23) levels, resulting in hypophosphatemia and decreased production of 1,25 dihydroxyvitamin D (1,25D). In addition to rickets and osteomalacia, long bones from mice with XLH (Hyp) have impaired whole-bone biomechanical integrity accompanied by increased osteocyte apoptosis. To address whether perilacunar/canalicular remodeling is altered in Hyp mice, histomorphometric analyses of tibia and 3D intravital microscopic analyses of calvaria were performed. These studies demonstrate that Hyp mice have larger osteocyte lacunae in both the tibia and calvaria, accompanied by enhanced osteocyte mRNA and protein expression of matrix metalloproteinase 13 (MMP13) and genes classically used by osteoclasts to resorb bone, such as cathepsin K (CTSK). Hyp mice also exhibit impaired canalicular organization, with a decrease in number and branching of canaliculi extending from tibial and calvarial lacunae. To determine whether improving mineral ion and hormone homeostasis attenuates the lacunocanalicular phenotype, Hyp mice were treated with 1,25D or FGF23 blocking antibody (FGF23Ab). Both therapies were shown to decrease osteocyte lacunar size and to improve canalicular organization in tibia and calvaria. 1,25D treatment of Hyp mice normalizes osteocyte expression of MMP13 and classic osteoclast markers, while FGF23Ab decreases expression of MMP13 and selected osteoclast markers. Taken together, these studies point to regulation of perilacunar/canalicular remodeling by physiologic stimuli including hypophosphatemia and 1,25D. © 2017 American Society for Bone and Mineral Research.
Hydroxyethyl starch and kidney function: A retrospective study in patients undergoing therapeutic plasma exchange
Authors: Radhakrishnan Muthuchellappan , Batra Akshay , Periyavan Sundar , Philip Mariamma , Anand Vivek 
Published: October 2017

AbstractPurposeHydroxyethyl starch (HES) and albumin are used as replacement fluids during therapeutic plasma exchange (TPE). HES solutions are no longer recommended in critically ill patients due to its effect on kidneys and coagulation. In this retrospective study, we tried to look at the association between cumulative HES administration and kidney function in patients undergoing TPE.MethodsTransfusion medicine department register was scrutinized to identify adult patients who had completed at least 5 cycles of TPE during the period June 2014–May 2015. Patient demographics, indication for TPE, amount of plasma removed, amount of colloid administered, adverse events and vascular access details were collected. Electronic hospital database was scrutinized to retrieve lab parameters, including blood urea and serum creatinine (before and after 5 cycles of TPE) and platelet count. Baseline renal parameters were compared with post TPE values using Wilcoxon signed rank test. A p value <0.05 was kept as significant.ResultsOf the 593 patients who received TPE during the study period, 104 patients fulfilled the inclusion criteria. Forty‐five patients out of 104 received TPE in the intensive care unit. All patients received 2500 ml of HES during the study period. Blood urea and serum creatinine values, when compared to baseline, significantly decreased after 5 cycles of TPE (p = 0.004, p = 0.001, respectively).ConclusionBlood urea and serum creatinine, used as markers of renal function, improved in patients requiring multiple doses of HES solutions during TPE. Further studies using novel renal biomarkers are required to examine whether HES induces any structural damage to kidneys.
Reciprocity Between Parental Psychopathology and Oppositional Symptoms From Preschool to Middle Childhood
Authors: Antúnez Zayra , de la Osa Nuria , Granero Roser , Ezpeleta Lourdes 
Published: October 2017

ObjectiveOppositional defiant disorder (ODD) is a common disorder in preschool children. Evidence indicates that maternal and paternal psychopathology, particularly aggressive behavior and anxious and depressed symptoms, contributes to the development of this disorder. The latest research also suggests that ODD symptoms may exacerbate the mental health problems of parents. Our aim was to establish the existence of a reciprocal association between paternal and maternal psychopathology (aggression, depression, and anxiety) and child ODD at ages 3 and 8, using a longitudinal design in a community sample of preschoolers.MethodThe sample included 331 children evaluated at ages 3 and 8 through questionnaires and a semistructured diagnostic interview with parents. Parents also informed about their own psychopathology.ResultsAt 3 years of age, higher levels of ODD symptoms in girls were concurrently associated with maternal anxious and depressed symptoms and paternal aggressive behavior, and higher levels of ODD symptoms in boys were concurrently associated with maternal aggressive behavior. Longitudinally, for boys, higher levels of maternal anxious and depressed symptoms at child age 3 predicted increases in ODD symptoms from 3 to 8 years of age. In addition, higher levels of ODD symptoms in boys aged 3–8 years predicted increases in fathers’ anxious and depressive symptoms.ConclusionChildren with ODD should be evaluated and treated promptly, but efforts should be extended to their parents. Mothers’ and fathers’ mental health must be explored because the psychopathologies of children and parents reciprocally affect each other.
Automated vessel exclusion technique for quantitative assessment of hepatic iron overload by ‐MRI
Authors: Tipirneni‐Sajja Aaryani , Song Ruitian , McCarville M. Beth , Loeffler Ralf B. , Hankins Jane S. , Hillenbrand Claudia M. 
Published: October 2017

BackgroundExtraction of liver parenchyma is an important step in the evaluation of
‐based hepatic iron content (HIC). Traditionally, this is performed by radiologists via whole‐liver contouring and
‐thresholding to exclude hepatic vessels. However, the vessel exclusion process is iterative, time‐consuming, and susceptible to interreviewer variability.PurposeTo implement and evaluate an automatic hepatic vessel exclusion and parenchyma extraction technique for accurate assessment of
‐based HIC.Study TypeRetrospective analysis of clinical data.SubjectsData from 511 MRI exams performed on 257 patients were analyzed.Field Strength/SequenceAll patients were scanned on a 1.5T scanner using a multiecho gradient echo sequence for clinical monitoring of HIC.AssessmentAn automated method based on a multiscale vessel enhancement filter was investigated for three input data types—contrast‐optimized composite image,
map, and
map—to segment blood vessels and extract liver tissue for
‐based HIC assessment. Segmentation and
results obtained using this automated technique were compared with those from a reference
‐thresholding technique performed by a radiologist.Statistical TestsThe Dice similarity coefficient was used to compare the segmentation results between the extracted parenchymas, and linear regression and Bland‐Altman analyses were performed to compare the
results, obtained with the automated and reference techniques.ResultsMean liver
values estimated from all three filter‐based methods showed excellent agreement with the reference method (slopes 1.04–1.05, R2 > 0.99, P < 0.001). Parenchyma areas extracted using the reference and automated methods had an average overlap area of 87–88%. The
‐thresholding technique included small vessels and pixels at the vessel/tissue boundaries as parenchymal area, potentially causing a small bias (<5%) in
values compared to the automated method.Data ConclusionThe excellent agreement between reference and automated hepatic vessel segmentation methods confirms the accuracy and robustness of the proposed method. This automated approach might improve the radiologist's workflow by reducing the interpretation time and operator dependence for assessing HIC, an important clinical parameter that guides iron overload management.Level of Evidence: 3Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2018;47:1542–1551.
Response of viticulture‐related climatic indices and zoning to historical and future climate conditions in Greece
Authors: Koufos G. C. , Mavromatis T. , Koundouras S. , Jones G. V. 
Published: October 2017

ABSTRACTClimate and viticulture are indisputably linked and thus knowledge of the predominant weather and climate conditions of a given area is essential for optimum variety selection, viable production and overall wine quality. In this study, an assessment of the current (1981–2010) and future conditions (2021–2050 and 2061–2090) through principal climatic elements and six bioclimatic indices (i.e. Growing season average temperature, growing degree‐days, Huglin index, biologically effective degree‐days, dryness index and cool night index) at 23 weather stations proximal to the key mainland, coastal and island viticultural areas of Greece was performed. Mainland locations were generally colder due to their wider variety of terroir aspects and elevation, while coastal locations and islands faced proportionally more extreme temperatures and drier conditions. Trend analysis revealed that minimum temperatures increased at higher rates than the respective maximum temperatures at most locations. Climate change scenarios derived from the regional climate model RegCM4 suggested significant shifts towards warmer and drier conditions across all locations in the future. These conditions are very likely to advance phenology and harvest beyond what is considered suitable and will likely have detrimental impacts on wine quality. Differences in impacts will likely be seen between wine areas currently cultivated with early ripening (reducing variety suitability)versusthose with later‐ripening (increasing consistency in ripening) varieties. Overall, the changes projected for the future climate will challenge the Greek wine industry to increase its adaptive capacity through better understanding of temperature thresholds for the varieties grown and the adoption of new cultivation techniques and strategies.
Intensified impact of North Atlantic Oscillation in May on subsequent July Asian inland plateau precipitation since the late 1970s
Authors: Piao Jinling , Chen Wen , Chen Shangfeng , Wei Ke 
Published: October 2017

ABSTRACTThe relationship between the North Atlantic Oscillation (NAO) in May and precipitation in the Asian inland plateau (AIP) in following July has experienced a significant enhancement since the late 1970s. This study investigates the factors for this inter‐decadal change of the NAO–AIP precipitation connection. Before the late 1970s, geopotential height anomalies related to the May NAO exhibited a dipole pattern confined to the North Atlantic from May to June and decayed in July. As a result, the impact of the May NAO on the AIP precipitation in July is weak. In contrast, after the late 1970s, geopotential height anomalies associated with the May NAO persisted into July. The analysis in this study finds that the May NAO influences July AIP precipitation via modulating the Polar–Eurasia teleconnection (POL). After (before) the late 1970s, the connection between the May NAO and the POL was strong (weak), explaining the inter‐decadal change in the May NAO–July AIP precipitation relationship. Further analysis suggests that the strengthening of the relationship between the May NAO pattern and the July POL after the late 1970s may be attributed to the inter‐decadal contraction of the Northern Hemisphere circumpolar vortex.
An observer‐metamerism sensitivity index for electronic displays
Authors: Le Moan Steven , Tanksale Tejas Madan , Byshko Roman , Urban Philipp 
Published: October 2017

AbstractThe effect of observer metamerism induced by electronic displays depends to a large extent on their primary spectra (red, green, and blue in the most common case). In particular, for narrow‐band primary spectra whose peak wavelength lies in the range of high variability of the observer's color‐matching function, some observers can experience very large differences between actual surface colors (e.g. in a light booth) and displayed colors if the monitor is optimized for the International Commission on Illumination (CIE) 1931 standard observer. However, because narrow‐band light‐emitting diodes lead to larger color gamuts, more and more monitors with very narrow band primaries are coming onto the market without manufacturers taking into account the associated problem of observer variations. Being able to measure these variations accurately and efficiently is therefore an important objective. In this paper, we propose a new approach to predict the extent of observer metamerism for a particular multiprimary display. Unlike existing dedicated models, ours does not depend on a reference illuminant and a set of reflectance spectra and is computationally more efficient.
Does the Pringle maneuver affect survival and recurrence following surgical resection for hepatocellular carcinoma? A western series of 441 patients
Authors: Famularo Simone , Giani Alessandro , Di Sandro Stefano , Sandini Marta , Giacomoni Alessandro , Pinotti Enrico , Lauterio Andrea , Gianotti Luca , De Carlis Luciano , Romano Fabrizio 
Published: October 2017

BackgroundThe impact of the Pringle maneuver (PM) on long‐term outcome after curative resection for hepatocellular carcinoma (HCC) is controversial, with eastern series reporting conflicting results. We aim to evaluate the impact of the PM in a western cohort.MethodsWe retrospectively analyzed patients with HCC who underwent liver resection between January 2001 and August 2015. Patients were divided in two groups based the use of the PM during resection. Primary outcomes were overall survival (OS) and disease‐free survival (DFS).ResultsA total of 441 patients were analyzed. Of these, 176 patients (39.9%) underwent PM. Median OS was 46.4 months (95%CI: 34.1‐58.7) for the PM group and 56.5 months (95%CI: 37.1‐75.9) for the no‐PM group (P = 0.188), with a median DFS of 26.7 months (95%CI: 15.7‐37.7) and 24.9 months (95%CI: 18.1‐31.7), respectively (P = 0.883).ConclusionsThese results suggest that PM does not increase the risk of tumor recurrence or decrease long‐term survival.
Separation of selenium species and their sensitive determination in rice samples by ion‐pairing reversed‐phase liquid chromatography with inductively coupled plasma tandem mass spectrometry
Authors: Gao Huan‐Huan , Chen Ming‐Xue , Hu Xian‐Qiao , Chai Shuang‐Shuang , Qin Mei‐Ling , Cao Zhao‐Yun 
Published: October 2017

AbstractA highly sensitive method was developed for the simultaneous separation and determination of organic and inorganic selenium species in rice by ion‐pairing reversed‐phase chromatography combined with inductively coupled plasma tandem mass spectrometry. To achieve a good separation of these species, a comparison between anion‐exchange chromatography and ion‐pairing reversed‐phase chromatography was performed. The results indicated that ion‐pairing reversed‐phase chromatography was more suitable due to better separation and higher sensitivity for all analytes. In this case, a StableBond C18 column proved to be more robust or to have a better resolution than other C18 columns, when 0.5 mM tetrabutylammonium hydroxide and 10 mM ammonium acetate at pH 5.5 were used as the mobile phase. Moreover, an excellent sensitivity was obtained in terms of interferences by means of tandem mass spectrometry in the hydrogen mode. The detection limits were 0.02–0.12 μg/L, and recoveries of five selenium species were 75–114%, with relative standard deviations ≤ 9.4%. This method was successfully applied to the analysis of rice samples. Compared with previous studies, the proposed method not only gave comparable results when used for measuring selenium‐enriched rice, but it can provide greater sensitivity for the detection of low concentrations of selenium species in rice.
Simultaneous determination of isomeric substituted anilines by imidization with benzaldehyde and gas chromatography–mass spectrometry
Authors: Chen Mengmeng , Zhu Guohua , Wang Shanshan , Jiang Kezhi , Xu Jiaxiang , Liu Jinsong , Jiang Jianxiong 
Published: October 2017

AbstractThe chromatographic separation of several isomeric anilines is a challenging issue. Herein, a simple method for the simultaneous determination of four groups of isomeric primary aromatic amines, including chloroanilines, methylanilines, methoxylanilines, and dimethylanilines, was presented. In this method, all of the 15 primary aromatic amines were easily transformed into the corresponding imine derivative by treatment with benzaldehyde under mild conditions. The formed isomeric imine derivatives were completely separated on a commercial capillary gas chromatography column. The effects of several derivatization parameters were investigated and optimized. Linearity in the optimized method ranged from 0.050 to 50 μg/mL with the squared correlation coefficients (R2) between 0.9981 and 0.9999. Reasonable reproducibility was obtained, with the intraday relative standard deviation (N = 5) ranging from 0.89 to 4.57% and interday relative standard deviation ranging from 2.26 to 7.69% at the concentration of 5.0 μg/mL. The developed method has been successfully applied to determine these isomeric aromatic amines in real samples.
Examining Physical and Sexual Abuse Histories as Correlates of Suicide Risk Among Firefighters
Authors: Hom Melanie A. , Matheny Natalie L. , Stanley Ian H. , Rogers Megan L. , Cougle Jesse R. , Joiner Thomas E. 
Published: October 2017

AbstractResearch indicates that physical and sexual abuse are associated with increased suicide risk; however, these associations have not been investigated among firefighters—an occupational group that has been shown to be at elevated suicide risk. This study examined whether physical and sexual abuse histories are associated with (a) career suicide ideation, plans, and attempts; and (b) current suicide risk (controlling for theoretically relevant symptoms) in this occupational group. A sample of 929 U.S. firefighters completed self‐report surveys that assessed lifetime history of physical and sexual abuse; career suicide ideation, plans, and attempts; current suicide risk; and theoretically relevant symptoms. Logistic regression analyses revealed that individuals who reported a history of physical abuse were significantly more likely to report career suicide ideation, adjusted odds ratio [AOR] = 6.12, plans, AOR = 13.05, and attempts, AOR = 23.81, than those who did not. A similar pattern of findings emerged for individuals who reported a sexual abuse history, AORs = 7.83, 18.35, and 29.58 respectively. Linear regression analyses revealed that physical and sexual abuse histories each significantly predicted current suicide risk, even after controlling for theoretically relevant symptoms and demographics, pr2 = .07 and .06, respectively. Firefighters with a history of physical and/or sexual abuse may be at increased risk for suicidal thoughts and behaviors. A history of physical and sexual abuse were each significantly correlated with current suicide risk in this population, even after accounting for the effects of theoretically relevant symptoms. Thus, when conceptualizing suicide risk among firefighters, factors not necessarily related to one's firefighter career should be considered.
Killing them softly: degrees of inaccessible and Mahlo cardinals
Authors: Carmody Erin Kathryn 
Published: October 2017

AbstractThis paper introduces the theme of killing‐them‐softly between set‐theoretic universes. The main theorems show how to force to reduce the large cardinal strength of a cardinal to a specified desired degree. The killing‐them‐softly theme is about both forcing and the gradations in large cardinal strength. Thus, I also develop meta‐ordinal extensions of the hyper‐inaccessible and hyper‐Mahlo degrees. This paper extends the work of Mahlo to create new large cardinals and also follows the larger theme of exploring interactions between large cardinals and forcing central to modern set theory.
Non‐archimedean stratifications of tangent cones
Authors: García Ramírez Erick 
Published: October 2017

AbstractWe study the impact of a kind of non‐archimedean stratifications (t‐stratifications) on tangent cones of definable sets in real closed fields. We prove that such stratifications induce stratifications of the same nature on the tangent cone of a definable set at a fixed point. As a consequence, the archimedean counterpart of a t‐stratification is shown to induce Whitney stratifications on the tangent cones of a semi‐algebraic set. Extensions of these results are proposed for real closed fields with further structure.
Self‐Healing Sensors Based on Dual Noncovalent Network Elastomer for Human Motion Monitoring
Authors: Cao Jie , Zhang Xu , Lu Canhui , Luo Yongyue , Zhang Xinxing 
Published: October 2017

AbstractNowadays, it is still a challenge to prepare flexible sensors with great mechanical strength, stretchability, high sensitivities, and excellent self‐healing (SH) abilities. Herein, a nanostructured supramolecular elastomer is reported with a dual noncovalent network of hydrogen bonding interactions and metal–ligand coordination. The resultant flexible sensor presents ultrafast (30 s), autonomous, and repeatable SH ability with high healing efficiency (80% after the 3rd healing process), as well as enhanced mechanical properties. Benefitting from the 3D conductive network, the sensor exhibits high electrical sensitivity and very low detection limit (0.2% strain). As a result, the flexible sensor is capable of precisely monitoring small strains of human motions (such as vocal‐cord vibration), and exhibits reproducible and recognizable current signals after cutting–healing process. The dual noncovalent network design proposed here opens up a new opportunity for scalable fabrication of high performance SH sensors and other electronic devices.
Building horizontal coordination in Sri Lanka
Authors: Samaratunge Ramanie , O'Neill Deirdre , Coghill Ken , Wijayarathne B. 
Published: October 2017

SummaryHorizontal coordination is a focal topic in contemporary public management. However, greater attention has been given to developed states while developing countries struggle to improve the quality of public service delivery amidst skills shortages and siloed organisations. This article presents a foreign‐funded training programme designed to promote horizontal coordination at the most local level of government in a developing country, Sri Lanka, and analyses the factors that contributed to its success. Using data collected through participant surveys, focus groups, and programme‐related projects, the article shows how the formation of a “locally directed, donor‐supported” programme aligned with national development priorities that enabled the country‐level partner institution to deliver a programme that improved horizontal coordination and enhanced delivery of public services. Although findings confirm the importance of contextualising programme design, content, and delivery for achieving aid effectiveness, a novel conclusion was that the participation of elected officials alongside career public servants greatly contributed to the programme's success by creating new levels of trust and facilitating more productive working relationships between key stakeholders, culminating in improved outcomes for local communities. This suggests that elected officials can play a key role in building horizontal coordination in developing nations.