bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angiotensin-Converting Enzyme DD Polymorphism is Associated with Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease
Authors: Ceyhan Koksal , Kadi Hasan , Celik Atac , Burucu Turgay , Koc Fatih , Sogut Erkan , Sahin Semsettin , Onalan Orhan 
Published: May 2016

Objectives Although association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and cardiovascular diseases was reported by many studies, the relation between ACE I/D polymorphism and coronary collateral circulation (CCC) has not been studied yet. The aim of the present study was to investigate a possible relationship between ACE I/D polymorphism and CCC. Methods Patients who were subjected to coronary angiography in the 2006 to 2009 period and had at least a completely occluded major artery were included in this study. To classify collateral circulation, we used the Rentrop classification. Patients were classified as having poor CCC (Rentrop grades 0 to 1) or good CCC (Rentrop grades 2 to 3). Gene polymorphism was detected through the detailed melting curve analysis of polymerase chain reaction products after amplification using real-time polymerase chain reaction method and LightCycler 1.5 apparatus. Results We prospectively studied 113 patients who had at least 1 totally occluded major epicardial coronary artery. Forty-seven patients had poor CCC and 67 patients had good CCC. There were no differences among groups in age, sex, risk factors, lipid profile, uses of cardiovascular drugs, and number of diseased vessels. Plasma ACE levels were significantly higher in poor CCC group ( P < 0.001). The frequency of DD polymorphism was higher in the poor CCC group ( P < 0.001). In allele frequency, we found that the frequency of the D allele was higher in poor CCC group than in the good CCC group (95% confidence interval [CI], 2.16–7.38; P < 0.001). Multiple regression analysis with CCC development as the dependent variable revealed that the presence of total occlusion of the left circumflex artery (95% CI, 1.29–6.6; P = 0.001), ACE DD genotype (95% CI, 2.55–12.79; P = 0.001), presence of diabetes (95% CI, 1.03–3.16; P = 0.005), and pulse pressure (95% CI, 1.04–1.56; P = 0.045) were independent determinants of poor coronary collateral development. Conclusions This study showed that ACE DD polymorphism is associated with poor CCC. Poor collateral circulation in patients carrying the D allele may be associated with endothelial dysfunction and elevated blood ACE levels in these patients.
“The Many Languages of the Avant-Garde”: In conversation with Grzegorz Bral of Teatr Pieśń Kozła (Song of the Goat Theatre)
Authors: Sakowska Aleksandra 
Published: May 2016

AbstractHow to theorise and review avant-garde Shakespeare? Which theoretical paradigms should be applied when Shakespearean productions are multicultural and yet come from a specific locale? These and other many questions interrogating the language of performance in global avant-garde Shakespeare productions are put forward to Grzegorz Bral, the director of the Song of the Goat ensemble in the context of their evolving performance of Macbeth (2006/2008) and their Songs of Lear (2012).
Looking Back at the Audience: The RSC & The Wooster Group’s Troilus and Cressida (2012)
Authors: Mancewicz Aneta 
Published: May 2016

AbstractThe controversy around the RSC & The Wooster Group’s Troilus and Cressida (Stratford-upon-Avon 2012) among the spectators and critics in Britain revealed significant differences between the UK and the US patterns of staging, spectating, and reviewing Shakespeare. The production has also exposed the gap between mainstream and avant-garde performance practices in terms of artists’ assumptions and audiences’ expectations. Reviews and blog entries written by scholars, critics, practitioners, and anonymous theatre goers were particularly disapproving of The Wooster Group’s experimentation with language, non-psychological acting, the appropriation of Native American customs, and the overall approach to the play and the very process of stage production. These points of criticism have suggested a clear perception of a successful Shakespeare production in the mainstream British theatre: a staging that approaches the text as an autonomous universe guided by realistic rules, psychological principles, and immediate political concerns. If we assume, however, that Troilus and Cressida as a play relies on the dramaturgy of cultural differences and that it consciously reflects on the notion of spectatorship, the production’s transgression of mainstream patterns of staging and spectating brings it surprisingly close to the Shakespearean source.
Assessment of dual inhibitory activity of epifriedelanol isolated from <i>Cayratia trifolia</i> against ovarian cancer
Authors: Perumal Palanisamy Chella , Sowmya Sundaram , Velmurugan Devadasan , Sivaraman Thirunavukkarasu , Gopalakrishnan Velliyur Kanniappan 
Published: May 2016

<p class="Abstract"><em>Cayratia trifolia</em> is used as diuretic, in tumors, neuralgia and splenopathy. However, compounds depicting anti-ovarian cancer activities from this plant source have not yet been identified and structurally characterized till date. In the present study, X-ray structure of epifriedelanol, a bioactive compound, isolated from the ethanolic extract of the <em>C. trifolia</em> and its binding affinities against a few proteins (HER2, EGFR and CXCR4) that are reported to get overexpressed under ovarian cancer had been thoroughly studied by using molecular docking means. Binding affinities of the compound vis-à-vis that of carboplatin, a FDA approved drug to the ovarian cancer, to interact with the protein targets are quite impressive. The drug-likeness properties of the epifriedelanol and scope to develop the compound as a potent anti-ovarian cancer drug are discussed in this paper.</p><p> </p>
Nerve sparing clitoroplasty in a rare case of idiopathic clitoromegaly
Authors: Kujur Abha Rani , Joseph Vijay , Chandra Praveen 
Published: May 2016

ABSTRACTClitoromegaly is an embarrassing condition causing psychological stress, requiring intervention. The goals of clitoroplasty are to achieve normal genital anatomy and to preserve tactile sensation with a satisfactory sexual response. We present a rare case of idiopathic clitoromegaly managed by reduction clitoroplasty, preserving the dorsal neurovascular bundle and extensive network of nerves around the corpora to the glans and the creation of labia minora.
Glial heterotopia of the lip: A rare presentation
Authors: Dadaci Mehmet , Bayram Fazli Cengiz , Ince Bilsev , Bilgen Fatma 
Published: May 2016

ABSTRACTGlial heterotopia represents collections of normal glial tissue in an abnormal location distant to the central nervous system or spinal canal with no intracranial connectivity. Nasal gliomas are non-neoplastic midline tumours, with limited growth potential and no similarity to the central nervous system gliomas. The nose and the nasopharynx are the most common sites of location. Existence of glial heterotopia in the lip region is a rare developmental disorder. We report a case of large glial heterotopia in the upper lip region in a full-term female newborn which had intracranial extension with a fibrotic band. After the surgery, there was no recurrence in the follow-up period of 3 years. When glial heterotopia, which is a rare midline anomaly, is suspected, possible intracranial connection and properties of the mass should be evaluated by magnetic resonance imaging. By this way, lower complication rate and better aesthetic results can be achieved with early diagnosis and proper surgery.
Successful microsurgical replantation of an amputated penis
Authors: Garg Sanchit , Date Shivprasad V. , Gupta Arunesh , Baliarsing Amresh S. 
Published: May 2016

ABSTRACTPenile amputation is an uncommon injury for which immediate surgical replantation is warranted. Microsurgical replantation is the “standard” method for penile replantation. Early replantation yields a high success and low complication rate. We report a case of a 34-year-old male who presented with amputation at the proximal penile shaft which was successfully replanted using microsurgical techniques. Minor skin necrosis was noted post-operatively which was debrided and covered with skin graft. Follow-up at 6 months showed satisfactory cosmetic appearance, normal voiding, return of sensations and erectile function. The level of evidence was V.
Effectiveness of an Interprofessional and Multidisciplinary Musculoskeletal Training Program
Authors: Battistone Michael J. , Barker Andrea M. , Grotzke Marissa P. , Beck J. Peter , Berdan Jeffery T. , Butler Jorie M. , Milne Caroline K. , Huhtala Tim , Cannon Grant W. 
Published: May 2016

ABSTRACT

Musculoskeletal (MSK) problems are common, and a recent US Bone and Joint Initiative calls for new models of education and professional collaboration. Evidence of feasibility and acceptability of innovative methods are needed.Background

We assessed if an experimental immersion interdisciplinary MSK curriculum would be acceptable to residents from different specialties, be feasible within existing rotations, and be effective in strengthening clinical skills.Objective

Through funding from the Veterans Affairs Office of Academic Affiliations and the Office of Specialty Care, we developed a Center of Excellence in MSK Care and Education. A core element is the monthly MSK Education Week, which teaches skills and provides opportunities to apply these in clinical settings. Participants include internal medicine, physical medicine and rehabilitation, and orthopaedic surgery residents, as well as students and residents from other health professions programs. All were assigned to the MSK week in lieu of other clinical experiences. Faculty encompassed primary care, rheumatology, endocrinology, orthopaedics, and physical medicine and rehabilitation. Assessments include surveys and a 2-station objective structured clinical examination (OSCE).Methods

Since 2012, a total of 176 trainees have participated. Percentage of trainees reporting ability to evaluate and manage MSK complaints increased (9% to 87% for shoulder; 18% to 86% for knee), and confidence performing MSK injections increased from 10% to 70%. Competency in evaluation of shoulder and knee pain was confirmed by OSCEs.Results

The MSK week program was accepted by residents from the 3 specialties, with learners reporting improved ability to perform shoulder and knee examinations, as demonstrated by OSCEs.Conclusions
Pogledi ljubezni in sovraštva: Kulturni vzorci zrenja in čustvovanja v starogrški kulturi
Authors: Cairns Douglas L. 
Published: May 2016

Članek se ukvarja s stičnimi točkami med kulturnimi vzorci čustvovanja, predvsem ljubezni in zavisti, ter poljudnimi in znanstvenimi vzorci zrenja v stari Grčiji. Čeprav se vloga oči v izražanju teh čustev lahko prekriva s splošno razširjenim prepričanjem, da je gledanje ‘haptičen’, snoven proces, soroden dotiku, pa konceptov, povezanih s čustvovanjem, ni mogoče zajeti v enotno in vseobsegajočo teorijo o fizičnih učinkih zrenja in stanj, ko smo predmet opazovanja. V primerih, ko se posamezni kulturni vzorci zrenja (‘aktivni’, ‘pasivni’ in ‘interaktivni’) ujemajo s kulturnimi vzorci čustvovanja, se besedila nanje sklicujejo; kadar je ujemanje manj izrazito, jih prilagajajo; kadar ujemanja ni, jih preprosto zanemarijo. Prevod Sonja Weiss.
Mešana ustava (res publica mixta) pri Ciceronu
Authors: Sadek Mitja 
Published: May 2016

Članek je posvečen antični teoriji o mešani ustavi, zlasti pa Ciceronovi uporabi te ideje v Državi. Po interpretaciji, ki jo podaja avtor, je treba politične ideje Države razumeti v kontekstu Ciceronovega političnega položaja v času, ko je dialog nastal. V nasprotju z zelo razširjenim prepričanjem, da je Državaizraz pro-pompejanskega monarhizma, je mogoče pokazati, da je Cicero v ideji o mešani ustavi videl predvsem sredstvo za ponovno vzpostavitev ravnotežja med konzuloma, senatom in komiciji. Sklepni del prispevka je posvečen kontroverzni tezi Aloisa Riklina, ki iz pregleda novoveške recepcije idej o mešani ustavi izpelje sklep, da paradigma delitve oblasti, ki je temelj sodobne predstavniške demokracije, izvira prav iz antične teorije o mešani ustavi.
Pikareskni pisec: kaj lahko branje Apulejevih Metamorfoz razkrije o Lazarčku s Tormesa (in obratno)
Authors: Rott Zala 
Published: May 2016

Članek obravnava Apulejeve Metamorfoze in španski pikareskni roman Lazarček s Tormesa. Posveča se podobnostim v zgradbi obeh romanov, ki so: prvoosebni pripovedovalec, retrospektivna pripoved o življenju v službi različnih gospodarjev, Fortuna kot ključni pripovedni mehanizem; poleg tega pa tudi manj očitnim vsebinskim podobnostim, temam govora in pisanja ter literarnih ambicij.
Priamel v grški književni tradiciji in enumeracija v indoevropščini
Authors: Galjanić Ana 
Published: May 2016

Članek analizira strukturo grške pesniške oblike, imenovane ‘priamel’, jo primerja s podobnimi tvorbami v sorodnih literarnih tradicijah in navaja številne strukturno podobne odlomke v vedski, valižanski in srbohrvaški literaturi v dokaz, da ne gre za izoliran pojav. Študija umesti priamel v širši kontekst pesniških enumeracij in opozori na tipološka ujemanja med priamelom in posebno zvrstjo pesniškega spiska, imenovano ‘bounded set’.
Phoebus volentem proelia me loqui: Kalimahov Apolon pri Horaciju
Authors: Tomc Kristina 
Published: May 2016

Kalimahova upodobitev Apolona v Prologu k pesnitvi Ajtia je postala zgled za številne recusationes v poeziji avgustejske dobe. Članek prikaže in analizira paralelna mesta v Horacijevem opusu: prenos Apolonove vloge na drugo božanstvo v C. 1.6, C. 1.19, Epod. 14 in S. 1.10, preoblikovanje Apolonovega navodila v prošnjo Merkurju v S. 2.6 in svarilo Horacijevega Apolona v C. 4.15. Največ pozornosti je deležna zadnja pesem, v kateri lahko razberemo tudi očitne aluzije na Vergilijevo in Propercijevo poezijo.
Veteres igitur primique Romani: rimsko kraljestvo in republika v zgodnji latinski krščanski apologetiki
Authors: Maver Aleš 
Published: May 2016

Razprava obravnava podobo zgodnjih obdobij rimske zgodovine pri nekaterih zgodnjih latinsko pišočih krščanskih apologetih. Čeprav sta zgodnjo rimsko zgodovino kolikor toliko sistematično v apologetskem slovstvu obravnavala šele Avguštin in Orozij, so se že zgodnji apologeti posvečali nekaterim njenim značilnim temam. V razpravo vključena besedila nekako obvladuje negativni pogled na začetke Rima, kar še posebej velja za Oktavija Minucija Feliksa. Po drugi strani pa je moč prav tako najti številne zglede pozitivne uporabe (predvsem) dogodkov in likov iz časa republike. Zgodnji krščanski teologi so rimske pionirje občudovali zaradi njihove krepostnosti in moralne strogosti in hkrati vlekli vzporednice med njimi in krščanskimi mučenci. Sočasno so jim primeri pravnih in kultnih sprememb, do katerih je prihajalo že v prvih stoletjih Rima, omogočali lažje soočanje z nekaterimi ključnimi očitki poganske okolice. Zato v izročilu afriških apologetov koreninita tako Avguštinovo v glavnem pozitivno kot Orozijevo v glavnem negativno ovrednotenje obdobja rimskega kraljestva in republike.
Erōs in horasis v Plotinovem spisu O ljubezni
Authors: Weiss Sonja 
Published: May 2016

Članek obravnava Plotinovo teorijo ljubezni v okviru njegovega kontemplativnega nauka, ki lik Erosa kot »očesa« duše interpretira kot substancializiran odnos, čigar narava je sorodna tako duši kot predmetu njene ljubezni, ki je najvišje Lépo. Poleg tega skuša pravilno razumeti Plotinovo simboliko lika Penija iz Platonovega mita v Simpoziju; tam namreč Penija predstavlja vzrok nepopolne in nezadovoljne narave dajmonskega Erosa, pri Plotinu pa se kot še neopredeljivo zrenje vključuje celo v emanacijski proces nastanka Duše. Neopredeljiva narava, ki jo pri Plotinu predstavlja Penija, je pravzaprav odgovor na presežek Dobrega v duši, ki ga simbolizira Poros; iz nje rojeni Eros pa predstavlja gonilo kontemplativne dejavnosti Duše, ki se trudi doseči prvotno ravnovesje.
Izpod peresa dveh antiklasicistov: mit o Akteonu pri G. Brunu in G. B. Marinu
Authors: Farinelli Patrizia 
Published: May 2016

Prispevek skuša osvetliti, kako sta klasični mit o Aktajonu v postrenesančnem obdobju razumela antiklasicistična avtorja, kot sta Bruno in Marino. Namen prispevka je prikazati različnost njunih pristopov k mitu kljub dejstvu, da sta oba zavrnila klasicistično estetsko paradigmo. Giordano Bruno je mit resemantiziral v filozofskem smislu v enem izmed sonetov, ki sestavljajo dialog De gli eroici furori (1585), in ga uporabil za prikaz novega gnoseološkega koncepta. Giovan Battista Marino pa ga je obravnaval v idili iz zbirke La Sampogna (1620), pri čemer je opaziti njegovo nagnjenost k hiperliterarnosti in k učinkom presenečenja; ponudil je takšno verzijo mita, ki se lahko interpretira tudi v metatekstualnem smislu. V obeh primerih sem način pisanja vsakega od avtorjev primerjala z njunima poetološkima pozicijama in analizirala v luči intertekstualnih povezav. Prevod iz italijanšcine Andreja Nastasja Terbos.
[Laktancij]: Feniks (prevod)
Authors: Kvartič Gašper 
Published: May 2016

Daleč na Vzhodu je kraj, preblažen v svoji samoti, kjer na široko stoje duri neba zevajoč,tamkaj Sonce ne vzhaja nad zimskim, poletnim ne časom, le na pomlad z voza zliva njegova se luč.
Mark Tulij Ciceron: Pisma bratu Kvintu I, 1 (o upravi province)
Authors: Maver Aleš , Pirc Marija Neža , Sadek Mitja , Sajovic Miran , Vuk Nina 
Published: May 2016

Čeprav ne dvomim, da bodo mnogi glasniki, pa tudi človeške govorice same s svojo hitrostjo prehitele to pismo in boš tako že prej od drugih slišal, da se je mojemu hrepenenju in tvojemu naporu pridružilo še tretje leto, vendar sodim, da ti moram tudi sam prenesti to nadležno novico. Kajti v prejšnjih pismih, in to ne v enem, marveč v mnogih, sem ti ohranjal upanje, da se boš mogel kmalu vrniti, čeprav so drugi nad tem že obupali. Tega nisem počel le, da bi te kar najdlje razveseljeval s to prijetno mislijo, marveč tudi zato, ker smo tako jaz kot pretorji vložili toliko napora, da nisem dvomil, da bi se naš namen ne mogel posrečiti.
Fran Viljem Lipič, Bolezni Ljubljančanov (Morbi Lubeanorum) – maj, november
Authors: Hriberšek Matej 
Published: May 2016

Prevod in spremna predstavitev Matej Hriberšek. Od leta 2002 pa vse do danes na Inštitutu za zgodovino medicine Medicinske fakultete univerze v Ljubljani teče projekt, s katerim se slovenski medicinski stroki in širši slovenski javnosti predstavlja življenje in delo enega najpomembnejših zdravnikov, ki so kdaj koli delovali na slovenskem ozemlju, Frana Viljema Lipiča (1799-1845). Vodja tega projekta je zgodovinarka medicine doc. dr. Zvonka Zupanič Slavec; ta je organizirala prevajanje in poskrbela za izdajo treh temeljnih Lipičevih del, ki jih je zapustil po svojem 11-letnem obdobju delovanja na ljubljanskem področju (1823-1834). Deli Topografija Ljubljane in Dipsobiostatika sta izšla v prevodni in faksimilirani obliki in sta bogato pospremljeni s spremnimi študijami kompetentnih avtorjev. Tretje delo, Bolezni Ljubljančanov, je tik pred izidom in bo izšlo v enaki obliki kot prvi dve, prav tako pod uredniškim vodstvom dr. Zupanič-Slavčeve. Dela izhajajo v sozaložništvu Založbe ZRC in Znanstvenega društva za zgodovino zdravstvene kulture Slovenije.
Aligning and synchronization of MIS5 proxy records from Lake Ohrid (FYROM) with independently dated Mediterranean archives: implications for DEEP core chronology
Authors: Zanchetta Giovanni , Regattieri Eleonora , Giaccio Biagio , Wagner Bernd , Sulpizio Roberto , Francke Alex , Vogel Hendrik , Sadori Laura , Masi Alessia , Sinopoli Gaia , Lacey Jack H. , Leng Melanie J. , Leicher Niklas 
Published: May 2016

Abstract. The DEEP site sediment sequence obtained during the ICDP SCOPSCO project at Lake Ohrid was dated using tephrostratigraphic information, cyclostratigraphy, and orbital tuning through the marine isotope stages (MIS) 15-1. Although this approach is suitable for the generation of a general chronological framework of the long succession, it is insufficient to resolve more detailed palaeoclimatological questions, such as leads and lags of climate events between marine and terrestrial records or between different regions. Here, we demonstrate how the use of different tie points can affect cyclostratigraphy and orbital tuning for the period between ca. 140 and 70 ka and how the results can be correlated with directly/indirectly radiometrically dated Mediterranean marine and continental proxy records. The alternative age model presented here shows consistent differences with that initially proposed by Francke et al. (2015) for the same interval, in particular at the level of the MIS6-5e transition. According to this new age model, different proxies from the DEEP site sediment record support an increase of temperatures between glacial to interglacial conditions, which is almost synchronous with a rapid increase in sea surface temperature observed in the western Mediterranean. The results show how a detailed study of independent chronological tie points is important to align different records and to highlight asynchronisms of climate events. Moreover, Francke et al. (2016) have incorporated the new chronology proposed for tephra OH-DP-0499 in the final DEEP age model. This has reduced substantially the chronological discrepancies between the DEEP site age model and the model proposed here for the last glacial-interglacial transition.
High-frequency monitoring reveals nutrient sources and transport processes in an agriculture-dominated lowland water system
Authors: van der Grift Bas , Broers Hans Peter , Berendrecht Wilbert , Rozemeijer Joachim , Osté Leonard , Griffioen Jasper 
Published: May 2016

Abstract. Many agriculture-dominated lowland water systems worldwide suffer from eutrophication caused by high nutrient loads. Insight in the hydrochemical functioning of embanked polder catchments is highly relevant for improving the water quality in such areas or for reducing export loads to downstream water bodies. This paper introduces new insights in nutrient sources and transport processes in a polder in the Netherlands situated below sea level using high-frequency monitoring technology at the outlet, where the water is pumped into a higher situated lake, combined with a low-frequency water quality monitoring programme at six locations within the drainage area. Seasonal trends and short-scale temporal dynamics in concentrations indicated that the NO3 concentration at the pumping station originated from N loss from agricultural lands. The NO3 loads appear as losses via tube drains after intensive rainfall events during the winter months due to preferential flow through the cracked clay soil. Transfer function-noise modelling of hourly NO3 concentrations reveals that a large part of the dynamics in NO3 concentrations during the winter months can be related to rainfall. The total phosphorus (TP) concentration and turbidity almost doubled during operation of the pumping station, which points to resuspension of particulate P from channel bed sediments induced by changes in water flow due to pumping. Rainfall events that caused peaks in NO3 concentrations did not results in TP concentration peaks. The rainfall induced and NO3 enriched quick interflow, may also be enriched in TP but retention of TP due to sedimentation of particulate P then results in the absence of rainfall induced TP concentration peaks. Increased TP concentrations associated with run-off events is only observed during a rainfall event at the end of a freeze–thaw cycle. All these observations suggest that the P retention potential of polder water systems is primarily due to the artificial pumping regime that buffers high flows. As the TP concentration is affected by operation of the pumping station, timing of sampling relative to the operating hours of the pumping station should be accounted for when calculating P export loads, determining trends in water quality, or when judging water quality status of polder water systems.