bluuebunny/crossref_metadata_2025_split huggingface dataset:
Malaysia's Electoral System: Government of the People?
Authors: Tey Tsun Hang 
Published: July 2016

AbstractThis article seeks to examine the constitutional and legal aspects of Malaysia's election laws (within its first-past-the-post electoral system) seen within the broader socio-political context of Malaysia's plural society and ethnic-based political representation to evaluate if they conform to democratic principles and equitable standards. In particular, this article seeks to: (i) explore how the growth of the dominant political elite has had direct implications for the development of Malaysia's electoral regime and arrangements for the holding of democratic elections; (ii) survey the implementation and enforcement of the election laws, including the Elections Act, Election Offences Act, Election Commission Act, Election Petition Rules and Elections (Conduct of Elections) Regulations; (iii) examine the need of immunity for the Election Commission; (iv) examine the role of the judiciary; and (v) highlight the areas for urgent electoral reforms to restore public confidence in the electoral system and ensure the legitimacy of the political system.
Schisms in Humanitarianism – The Khmer Rouge Tribunal's First Hearing
Authors: Mohan Mahdev 
Published: July 2016

AbstractMass atrocity invokes humanitarian impulses in all of us. But when a genocidaire casts himself as a victim, the right response is less straightforward. This article analyzes a recent hearing of one of Cambodia's most feared Khmer Rouge cadres who stands trial before a newly established hybrid tribunal and suggests the consequences of responding to war crime trials with polemics rather than principle.
Review of The Constitutional Law of Indonesia: A Comprehensive Overview - The Constitutional Law of Indonesia: A Comprehensive Overview by Jimly Asshiddiqie [Selangor, Malaysia: Sweet & Maxwell Asia, 2009. li + 751 pp. Hardcover: $US 180.00]
Authors: Manan Munafrizal 
Published: July 2016

AbstractThis book review discusses a book written by Professor Jimly Asshiddiqie entitled The Constitutional Law of Indonesia: A Comprehensive Overview, published in 2009.
The Impact of China's Regulatory Regime on Foreign Franchisors' Entry and Expansion Strategies
Authors: Wang Zhiqiong June , Terry Andrew L. 
Published: July 2016

AbstractSince the “open doof” policies adopted by China in 1978 ended 30 years of isolation, introduced massive economic and legal reforms, encouraged foreign investment and resurrected private enterprise, China has become the world's second largest and fastest growing economy. In these circumstances, the development of franchising was inevitable. However, in addition to the normal commercial and cultural issues which challenge any franchise system in its international expansion, foreign franchisors proposing to enter China have faced additional regulatory obstacles. Market entry, participation in particular business sectors, and even the use of franchising as a method of business operation and expansion have all raised complex regulatory issues.This paper addresses the liberalisation of market access for foreign franchise systems under China's World Trade Organisation accession commitments, and the new regulatory regime for franchising in China under the 2007Commercial Franchise Regulation.
Hilal and Halal: How to Manage Islamic Pluralism in Indonesia?
Authors: Hosen Nadirsyah 
Published: July 2016

AbstractThe paper examines the tension amongst the Indonesian government and Islamic organisations in dealing with the plurality of interpretation within Islamic tradition and at the same time maintaining the unity and harmony of the Muslim ummah. I provide two case studies here: first, the issue of determining the first and the end of Ramadan and also 10 Zul Hijjah (for Idu al-Adha). Second, who has the authority to issue halal certificate? Due to different methods of hisab (astronomical calculation) and ru'yah (sighting a new crescent), Islamic organisations (Muhammadiyah, Nahdlatul Ulama and Majelis Ulama Indonesia) have produced different fatwas. At the same time, the Government has to make announcement on which dates to begin or to end fasting. With regard to the second issue, there is currently a tension between the Government and the MUI as the first thinks it falls into its authority whereas the latter insists that halal certificate is a written fatwa which belongs to its ‘jurisdiction’.The questions are: how does the government decide which fatwa to choose, and what are the reactions of Islamic organisations when their views differ with the position of the government? There is also tension in society in celebrating Idul Fitri and Idul Adha on different dates. How far should the government go to accommodate such different views, to maintain harmony in the community?
Muslim Personal Law and Citizens' Rights: The Case of Singapore
Authors: Rahman Noor Aisha Abdul 
Published: July 2016

AbstractPrevailing discourse on multiculturalismi tend to focus on its merits in protecting the cultures and traditions of minority groups within the framework of the politics of accommodation. Less discussed are its implications on the rights and autonomy of members of the groups themselves who may be adversely affected by the arrangement. This paper attempts to fill the lacunae. It focuses on the problems arising from autonomy granted to the Muslim community of Singapore to determine its personal law, on some segments of the community. Unlike the rest of the citizens of Singapore, the Muslims are bound by their personal law in the domain of the family which they cannot relinquish as long as they remain Muslims. The system which began during the period of British colonial administration has remained ever since. Differences in the mechanisms as well as the orientation of social agencies in determining the Muslim law from those affecting the nonMuslims, invite unwarranted implications on the rights of Muslims, specifically. The problem is reinforced by the strong tendency of state actors to over-rely on dominant groups within the Muslim community in determining matters of Muslim law at the expense of competing ideas and orientation. The absence of choice of law for Muslims poses a predicament to those who do not wish to renounce their religion but maintain differences in perceptions of the Muslim law. This paper analyzes these problems in the arena of the Muslim law on marriage, divorce and inheritance. It also highlights how the arrangement has, in some instances, resulted in the exclusion of Muslims as a whole from the purview of specific national laws and influence policies affecting them against the preferences of the group's members. These issues have generally received scant attention, if at all, eclipsed perhaps by the greater focus on the merits of multiculturalism in protecting minority rights. Some plausible ways, in which the unwitting implications of legal pluralism on the members of the Muslim community can be addressed, taking into consideration both their right as members of the group as well as citizens of the state, are also discussed.
The Dangers of the United Nations' “New Security Agenda”: “Human Security” in the Asia-Pacific Region
Authors: Saul Ben 
Published: July 2016

AbstractAmidst the understandable enthusiasm for enlarging the traditional state-centred view of security and embracing a “human security” agenda, little scholarly attention has been paid to the implications of this shift for international law. This article first charts the scope and genesis of “human security,” including within the United Nations and in the Asia-Pacific region, and traces the views of key Asian governments on the concept. It then analyses the relationship between human security and human rights and highlights the likely adverse impacts on human rights law. The remainder of the article considers how the human security agenda may destabilize the constitutional distribution of powers among UN organs under the UN Charter, especially by transferring power away from the more participatory General Assembly and towards the less representative and less accountable Security Council. In line with the position of some Asian States, this article reasserts that UN organs other than the Security Council, along with other major international institutions, are the appropriate bodies within which to pursue and address human security issues. In particular, the General Assembly and the Economic and Social Council require revitalization to avoid the trap of securitizing issues that are better framed as developmental and social concerns.
The Next Stage of Reforms: Korean Corporate Governance in the Post-Asian Financial Crisis Era
Authors: Kim Joongi 
Published: July 2016

AbstractFollowing the 1997 financial crisis, Korea underwent a dramatic overhaul of its corporate governance framework. Drastic changes in its legal and regulatory infrastructure led to more transparent and accountable companies. Boards of directors, shareholders, stakeholders, and auditors began to function effectively and even a corporate control market emerged. Many forms of internal and external corporate governance and market-oriented discipline were established. Korean companies are poised to make a quantum leap to reach the most competitive international levels of corporate governance. This paper argues that Korea must continue its reform efforts. It first discusses the Asian financial crisis and the first stage of reforms that followed. It then explores the areas where Korea needs to undergo the next stage of reforms. It will argue that only then can Korean corporations receive proper valuations. Korean companies have indeed come a long way but lingering perceptions of weak corporate governance thwart them from becoming world-class competitors.
Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3
Authors: Shan Tizhong , Xiong Yan , Zhang Pengpeng , Li Zhiguo , Jiang Qingyang , Bi Pengpeng , Yue Feng , Yang Gongshe , Wang Yizhen , Liu Xiaoqi , Kuang Shihuan 
Published: July 2016

AbstractBrown adipose tissue (BAT) dissipates energy through Ucp1-mediated uncoupled respiration and its activation may represent a therapeutic strategy to combat obesity. Here we show that Lkb1 controls BAT expansion and UCP1 expression in mice. We generate adipocyte-specific Lkb1 knockout mice and show that, compared with wild-type littermates, these mice exhibit elevated UCP1 expression in BAT and subcutaneous white adipose tissue, have increased BAT mass and higher energy expenditure. Consequently, KO mice have improved glucose tolerance and insulin sensitivity, and are more resistant to high-fat diet (HFD)-induced obesity. Deletion of Lkb1 results in a cytoplasm to nuclear translocation of CRTC3 in brown adipocytes, where it recruits C/EBPβ to enhance Ucp1 transcription. In parallel, the absence of Lkb1 also suppresses AMPK activity, leading to activation of the mTOR signalling pathway and subsequent BAT expansion. These data suggest that inhibition of Lkb1 or its downstream signalling in adipocytes could be a novel strategy to increase energy expenditure in the context of obesity, diabetes and other metabolic diseases.
A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting
Authors: Tantale Katjana , Mueller Florian , Kozulic-Pirher Alja , Lesne Annick , Victor Jean-Marc , Robert Marie-Cécile , Capozi Serena , Chouaib Racha , Bäcker Volker , Mateos-Langerak Julio , Darzacq Xavier , Zimmer Christophe , Basyuk Eugenia , Bertrand Edouard 
Published: July 2016

AbstractLive-cell imaging has revealed unexpected features of gene expression. Here using improved single-molecule RNA microscopy, we show that synthesis of HIV-1 RNA is achieved by groups of closely spaced polymerases, termed convoys, as opposed to single isolated enzymes. Convoys arise by a Mediator-dependent reinitiation mechanism, which generates a transient but rapid succession of polymerases initiating and escaping the promoter. During elongation, polymerases are spaced by few hundred nucleotides, and physical modelling suggests that DNA torsional stress may maintain polymerase spacing. We additionally observe that the HIV-1 promoter displays stochastic fluctuations on two time scales, which we refer to as multi-scale bursting. Each time scale is regulated independently: Mediator controls minute-scale fluctuation (convoys), while TBP-TATA-box interaction controls sub-hour fluctuations (long permissive/non-permissive periods). A cellular promoter also produces polymerase convoys and displays multi-scale bursting. We propose that slow, TBP-dependent fluctuations are important for phenotypic variability of single cells.
Systematic identification of protein combinations mediating chromatin looping
Authors: Zhang Kai , Li Nan , Ainsworth Richard I. , Wang Wei 
Published: July 2016

AbstractChromatin looping plays a pivotal role in gene expression and other biological processes through bringing distal regulatory elements into spatial proximity. The formation of chromatin loops is mainly mediated by DNA-binding proteins (DBPs) that bind to the interacting sites and form complexes in three-dimensional (3D) space. Previously, identification of DBP cooperation has been limited to those binding to neighbouring regions in the proximal linear genome (1D cooperation). Here we present the first study that integrates protein ChIP-seq and Hi-C data to systematically identify both the 1D- and 3D-cooperation between DBPs. We develop a new network model that allows identification of cooperation between multiple DBPs and reveals cell-type-specific and -independent regulations. Using this framework, we retrieve many known and previously unknown 3D-cooperations between DBPs in chromosomal loops that may be a key factor in influencing the 3D organization of chromatin.
Pentlandite rocks as sustainable and stable efficient electrocatalysts for hydrogen generation
Authors: Konkena Bharathi , junge Puring Kai , Sinev Ilya , Piontek Stefan , Khavryuchenko Oleksiy , Dürholt Johannes P. , Schmid Rochus , Tüysüz Harun , Muhler Martin , Schuhmann Wolfgang , Apfel Ulf-Peter 
Published: July 2016

AbstractThe need for sustainable catalysts for an efficient hydrogen evolution reaction is of significant interest for modern society. Inspired by comparable structural properties of [FeNi]-hydrogenase, here we present the natural ore pentlandite (Fe4.5Ni4.5S8) as a direct ‘rock’ electrode material for hydrogen evolution under acidic conditions with an overpotential of 280 mV at 10 mA cm−2. Furthermore, it reaches a value as low as 190 mV after 96 h of electrolysis due to surface sulfur depletion, which may change the electronic structure of the catalytically active nickel–iron centres. The ‘rock’ material shows an unexpected catalytic activity with comparable overpotential and Tafel slope to some well-developed metallic or nanostructured catalysts. Notably, the ‘rock’ material offers high current densities (≤650 mA cm−2) without any loss in activity for approximately 170 h. The superior hydrogen evolution performance of pentlandites as ‘rock’ electrode labels this ore as a promising electrocatalyst for future hydrogen-based economy.
CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
Authors: Jacoby Elad , Nguyen Sang M. , Fountaine Thomas J. , Welp Kathryn , Gryder Berkley , Qin Haiying , Yang Yinmeng , Chien Christopher D. , Seif Alix E. , Lei Haiyan , Song Young K. , Khan Javed , Lee Daniel W. , Mackall Crystal L. , Gardner Rebecca A. , Jensen Michael C. , Shern Jack F. , Fry Terry J. 
Published: July 2016

AbstractAdoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells targeting the CD19 B lineage receptor has demonstrated marked success in relapsed pre-B-cell acute lymphoblastic leukaemia (ALL). Persisting CAR-T cells generate sustained pressure against CD19 that may drive unique mechanisms of resistance. Pre-B ALL originates from a committed pre-B cell or an earlier progenitor, with potential to reprogram into other hematopoietic lineages. Here we report changes in lineage markers including myeloid conversion in patients following CD19 CAR therapy. Using murine ALL models we study the long-term effects of CD19 CAR-T cells and demonstrate partial or complete lineage switch as a consistent mechanism of CAR resistance depending on the underlying genetic oncogenic driver. Deletion of Pax5 or Ebf1 recapitulates lineage reprogramming occurring during CD19 CAR pressure. Our findings establish lineage switch as a mechanism of CAR resistance exposing inherent plasticity in genetic subtypes of pre-B-cell ALL.
Structural and compositional dependence of the CdTexSe1−x alloy layer photoactivity in CdTe-based solar cells
Authors: Poplawsky Jonathan D. , Guo Wei , Paudel Naba , Ng Amy , More Karren , Leonard Donovan , Yan Yanfa 
Published: July 2016

AbstractThe published external quantum efficiency data of the world-record CdTe solar cell suggests that the device uses bandgap engineering, most likely with a CdTexSe1−x alloy layer to increase the short-circuit current and overall device efficiency. Here atom probe tomography, transmission electron microscopy and electron beam-induced current are used to clarify the dependence of Se content on the photoactive properties of CdTexSe1−x alloy layers in bandgap-graded CdTe solar cells. Four solar cells were prepared with 50, 100, 200 and 400 nm-thick CdSe layers to reveal the formation, growth, composition, structure and photoactivity of the CdTexSe1−x alloy with respect to the degree of Se diffusion. The results show that the CdTexSe1−x layer photoactivity is highly dependent on the crystalline structure of the alloy (zincblende versus wurtzite), which is also dependent on the Se and Te concentrations.
Arabinoxylans, inulin and Lactobacillus reuteri 1063 repress the adherent-invasive Escherichia coli from mucus in a mucosa-comprising gut model
Authors: Van den Abbeele Pieter , Marzorati Massimo , Derde Melanie , De Weirdt Rosemarie , Joan Vermeiren , Possemiers Sam , Van de Wiele Tom 
Published: July 2016

AbstractThe microbiota that colonises the intestinal mucus may particularly affect human health given its proximity to the epithelium. For instance, the presence of the adherent-invasive Escherichia coli (AIEC) in this mucosal microbiota has been correlated with Crohn’s disease. Using short-term screening assays and a novel long-term dynamic gut model, which comprises a simulated mucosal environment (M-SHIME), we investigated how (potential) pro- and prebiotics may repress colonisation of AIEC from mucus. Despite that during the short-term screening assays, some of the investigated Lactobacillus strains adhered strongly to mucins, none of them competed with AIEC for mucin-adhesion. In contrast, AIEC survival and growth during co-culture batch incubations was decreased by Lactobacillus rhamnosus GG and L. reuteri 1063, which correlated with (undissociated) lactic acid and reuterin levels. Regarding the prebiotics, long-chain arabinoxylans (LC-AX) lowered the initial mucin-adhesion of AIEC, while both inulin (IN) and galacto-oligosaccharides (GOS) limited AIEC survival and growth during batch incubations. L. reuteri 1063, LC-AX and IN were thus retained for a long-term study with the M-SHIME. All treatments repressed AIEC from mucus without affecting AIEC numbers in the luminal content. As a possible explanation, L. reuteri 1063 treatment increased lactobacilli levels in mucus, while LC-AX and IN additionally increased mucosal bifidobacteria levels, thus leading to antimicrobial effects against AIEC in mucus. Overall, this study shows that pro- and prebiotics can beneficially modulate the in vitro mucosal microbiota, thus limiting occurrence of opportunistic pathogens among those mucosal microbes which may directly interact with the host given their proximity to the epithelium.
Composition dependence of charge and magnetic length scales in mixed valence manganite thin films
Authors: Singh Surendra , Freeland J. W. , Fitzsimmons M. R. , Jeen H. , Biswas A. 
Published: July 2016

AbstractMixed-valence manganese oxides present striking properties like the colossal magnetoresistance, metal-insulator transition (MIT) that may result from coexistence of ferromagnetic, metallic and insulating phases. Percolation of such phase coexistence in the vicinity of MIT leads to first-order transition in these manganites. However the length scales over which the electronic and magnetic phases are separated across MIT which appears compelling for bulk systems has been elusive in (La1−yPry)1−xCaxMnO3 films. Here we show the in-plane length scale over which charge and magnetism are correlated in (La0.4Pr0.6)1−xCaxMnO3 films with x = 0.33 and 0.375, across the MIT temperature. We combine electrical transport (resistance) measurements, x-ray absorption spectroscopy (XAS), x-ray magnetic circular dichroism (XMCD), and specular/off-specular x-ray resonant magnetic scattering (XRMS) measurements as a function of temperature to elucidate relationships between electronic, magnetic and morphological structure of the thin films. Using off-specular XRMS we obtained the charge-charge and charge-magnetic correlation length of these LPCMO films across the MIT. We observed different charge-magnetic correlation length for two films which increases below the MIT. The different correlation length shown by two films may be responsible for different macroscopic (transport and magnetic) properties.
A cholesterol-binding domain in STIM1 modulates STIM1-Orai1 physical and functional interactions
Authors: Pacheco Jonathan , Dominguez Laura , Bohórquez-Hernández A. , Asanov Alexander , Vaca Luis 
Published: July 2016

AbstractSTIM1 and Orai1 are the main components of a widely conserved Calcium influx pathway known as store-operated calcium entry (SOCE). STIM1 is a calcium sensor, which oligomerizes and activates Orai channels when calcium levels drop inside the endoplasmic reticulum (ER). The series of molecular rearrangements that STIM1 undergoes until final activation of Orai1 require the direct exposure of the STIM1 domain known as SOAR (Stim Orai Activating Region). In addition to these complex molecular rearrangements, other constituents like lipids at the plasma membrane, play critical roles orchestrating SOCE. PI(4,5)P2 and enriched cholesterol microdomains have been shown as important signaling platforms that recruit the SOCE machinery in steps previous to Orai1 activation. However, little is known about the molecular role of cholesterol once SOCE is activated. In this study we provide clear evidence that STIM1 has a cholesterol-binding domain located inside the SOAR region and modulates Orai1 channels. We demonstrate a functional association of STIM1 and SOAR to cholesterol, indicating a close proximity of SOAR to the inner layer of the plasma membrane. In contrast, the depletion of cholesterol induces the SOAR detachment from the plasma membrane and enhances its association to Orai1. These results are recapitulated with full length STIM1.