bluuebunny/crossref_metadata_2025_split huggingface dataset:
APEX, the Astrophysical Plasmadynamic EXplorer: An EUV High Resolution Spectroscopic Observatory
Authors: Kowalski M 
Published: March 2016

AbstractAPEX is a proposed Small Explorer satellite that will obtain high-resolution EUV spectra of white dwarfs, CVs, stellar coronae, and the local ISM. The APEX effective area (30-50 cm2) and resolution (~10,000) are an order of magnitude improvement over Chandra.
Mapping of Stellar Surfaces with Doppler and Zeeman Doppler Imaging
Authors: Cameron Andrew Collier 
Published: March 2016

AbstractDoppler imaging has been used to image dark spots on the surfaces of rapidly rotating, magnetically active stars for the last 20 years. More recently, methods have been developed for combining line-profile information from large numbers of spectral lines simultaneously. This has allowed starspot distributions to be mapped in sufficient detail to allow tracking of individual spots over several stellar rotations, delineating surface differential rotation patterns for a number of stars. Zeeman-Doppler imaging allows the creation of stellar magnetograms, which are providing the first insights into the 3D topology of stellar coronal magnetic fields. The advent of cryogenic infrared echelle spectrographs opens up exciting new possibilities for Doppler imaging in molecular lines of species such as TiO, OH, and FeH.
Systematically Peculiar Molecular Composition in M 82: Regarding the Formation Mechanisms
Authors: Takano S. , Nakai N. , Kawaguchi K. , Takano T , Schilke P. , Winnewisser G. 
Published: March 2016

AbstractA systematically peculiar molecular composition has been found in a nearby starburst galaxy M 82. Molecules related to grain surface formation and to production reactions favorable at high-temperature are deficient in M 82 among nearby galaxies with rich gas. These molecules are SO, SiO, NH3, HNCO, CH3OH, and CH3CN. Possible reasons for this peculiarity are discussed.
Millimetric Site Testing at Dome C: Results and Plans
Authors: Valenziano Luca , Dall’Oglio Giorgio , Graziani Andrea , Martinis Lorenzo , Pizzo Gabriella , Sabbatini Lucia 
Published: March 2016

AbstractResults relative to three campaigns at Dome Concordia, aimed to measure the millimetric sky noise, are presented. The atmospheric noise during summer seems to be definitely lower with respect to that measured with the same instrumentation in other geographical locations. We illustrate the scientific results obtained.
The Antarctic Planet Interferometer
Authors: Swain Mark R. 
Published: March 2016

AbstractThe Antarctic Planet Interferometer (API) is a concept for an infrared interferometer located at the best accessible site on Earth. Infrared interferometry is strongly effected by both the strength and vertical distribution of thermal and water vapor turbulence. The combination of low temperature, low wind speed, low elevation turbulence, and low precipitable water vapor make the Concordia base at Antarctic Dome C the best accessible site on Earth for infrared interferometry. The improvements in interferometer sensitivity with respect to other terrestrial sites are dramatic; an interferometer with two meter class telescopes could make unique infrared measurements of extra solar planets that might otherwise only be possible with a space-based interferometer.
CO 2-1 Mapping of WR16 with AST/RO
Authors: Tothill N. F. H. , Marston A. P. , Martin C. L. , Leppik K. 
Published: March 2016

AbstractMassive stars have profound effects on their surroundings, influencing them by their energetic stellar winds, and finally by supernova explosions. We present a CO 2-1 map of the surroundings of the Wolf-Rayet star WR16, taken with AST/RO at the South Pole, which shows some of these effects.
Designation of Multiple-star Components
Authors: Tokovinin Andrei 
Published: March 2016

AbstractHierarchical multiple stars need designations for individual components, for super-components (several bodies that act as single dynamical center and are often measured jointly) and sub-systems. Hierarchical designations like those proposed for WMC can satisfy all needs, but designations will have to be frozen and will not reflect true hierarchy in the future as new components are discovered. Hence, a clearing house (WMC on the web?) is needed to maintain unique and consistent designations. The hierarchy can be coded separately and flexibly by reference to parent super-components. As an example, these ideas are applied to a real quintuple star HR 1706.
A Simple Algorithm for Population Classification
Authors: Hu Peng , Hsieh Ming-Hua , Lei Ming-Jie , Cui Bin , Chiu Sung-Kay , Tzeng Chi-Meng 
Published: March 2016

AbstractA single-nucleotide polymorphism (SNP) is a variation in the DNA sequence that occurs when a single nucleotide in the genome differs across members of the same species. Variations in the DNA sequences of humans are associated with human diseases. This makes SNPs as a key to open up the door of personalized medicine. SNP(s) can also be used for human identification and forensic applications. Compared to short tandem repeat (STR) loci, SNPs have much lower statistical testing power for individual recognition due to the fact that there are only 3 possible genotypes for each SNP marker, but it may provide sufficient information to identify the population to which a certain samples may belong. In this report, using eight SNP markers for 641 samples, we performed a standard statistical classification procedure and found that 86% of the samples could be classified accurately under a two-population model. This study suggests the potential use of SNP(s) in population classification with a small number (n ≤ 8) of genetic markers for forensic screening, biodiversity and disaster victim controlling.
Regulatory Role of miR-203 in Occurrence and Progression of Kazakh Esophageal squamous cell carcinoma
Authors: Hu Jian Ming , Chang Ai Min , Chen Yun Zhao , Yuan Xiang Lin , Li Feng 
Published: March 2016

AbstractEsophageal carcinoma is one of the most common malignant tumors and the Kazakh national minority (ethnic) in Xinjiang (northwest of China) has been reported to be one of the highest incidence of Esophageal squamous cell carcinoma (ESCC) in the world. MicroRNA-203 (miR-203) was described as a tumor-suppressive miRNA in several cancers, but little study about the role of miR-203 in Kazakh ESCC. Therefore, we aimed to investigate the role of miR-203 in the occurrence and progression of Kazakh ESCC. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect miR-203 expression and immunohistochemistry (IHC) was used to examine P63 expression. The expression level of miR-203 in ESCC was significantly lower than that of cancer adjacent normal (CAN) samples (P < 0.05). Whereas the expression level of P63 in ESCC was significantly higher than that of CAN samples (P < 0.05), an inverse association between the expression of P63 and miR-203 was found but was not statistically significant (P > 0.05). These findings suggest that miR-203 is a tumor suppressor gene that plays an important role in inhibiting the occurrence of Kazakh ESCC in Xinjiang, China.
CD4+ and CD8+ TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells
Authors: Nakatsugawa Munehide , Rahman Muhammed A. , Yamashita Yuki , Ochi Toshiki , Wnuk Piotr , Tanaka Shinya , Chamoto Kenji , Kagoya Yuki , Saso Kayoko , Guo Tingxi , Anczurowski Mark , Butler Marcus O. , Hirano Naoto 
Published: March 2016

AbstractRecent high throughput sequencing analysis has revealed that the TCRβ repertoire is largely different between CD8+ and CD4+ T cells. Here, we show that the transduction of SIG35α, the public chain-centric HLA-A*02:01(A2)/MART127–35 TCRα hemichain, conferred A2/MART127–35 reactivity to a substantial subset of both CD8+ and CD4+ T cells regardless of their HLA–A2 positivity. T cells individually reconstituted with SIG35α and different A2/MART127–35 TCRβ genes isolated from CD4+ or CD8+ T cells exhibited a wide range of avidity. Surprisingly, approximately half of the A2/MART127–35 TCRs derived from CD4+ T cells, but none from CD8+ T cells, were stained by A2/MART127–35 monomer and possessed broader cross-reactivity. Our results suggest that the differences in the primary structure of peripheral CD4+ and CD8+ TCRβ repertoire indeed result in the differences in their ability to form extraordinarily high avidity T cells which would otherwise have been deleted by central tolerance.
Effective heterogeneous transition metal glycerolates catalysts for one-step biodiesel production from low grade non-refined Jatropha oil and crude aqueous bioethanol
Authors: Lau Pak-Chung , Kwong Tsz-Lung , Yung Ka-Fu 
Published: March 2016

AbstractThe utilization of bioethanol as the alcohol source for biodiesel production is more environmentally advantageous over methanol owing to its lower toxicity, lower flammability and its sustainable supply from renewable agricultural resources. However, as the presence of water in crude bioethanol is the critical factor limiting the biodiesel production process, the energy-intensive and costly purification of bioethanol is necessary for biodiesel application. Manganese glycerolate (MnGly) is reported the first time here as a robust heterogeneous catalyst that exhibited over 90% conversion by using aqueous ethanol containing 80 wt.% of water in the production of fatty acid ethyl ester (FAEE). The employment of 95 wt.% ethanol with respect to water could achieve 99.7% feedstock conversion in 6 hours under the optimal reaction conditions: reaction temperature (150 °C), feedstock-to-ethanol molar ratio (1:20) and catalyst loading (6 wt.%). Commercially available low grade crude bioethanol with the presence of impurities like sugars were applied which demonstrated remarkable catalytic activity in 24 hours. The high water tolerance of MnGly towards biodiesel production could eventually simplify the purification of bioethanol that consumes less energy and production cost.
Icariin attenuates titanium-particle inhibition of bone formation by activating the Wnt/β-catenin signaling pathway in vivo and in vitro
Authors: Wang Junhua , Tao Yunxia , Ping Zichuan , Zhang Wen , Hu Xuanyang , Wang Yijun , Wang Liangliang , Shi Jiawei , Wu Xiexing , Yang Huilin , Xu Yaozeng , Geng Dechun 
Published: March 2016

AbstractWear-debris-induced periprosthetic osteolysis (PIO) is a common clinical condition following total joint arthroplasty, which can cause implant instability and failure. The host response to wear debris promotes bone resorption and impairs bone formation. We previously demonstrated that icariin suppressed wear-debris-induced osteoclastogenesis and attenuated particle-induced osteolysis in vivo. Whether icariin promotes bone formation in a wear-debris-induced osteolytic site remains unclear. Here, we demonstrated that icariin significantly attenuated titanium-particle inhibition of osteogenic differentiation of mesenchymal stem cells (MSCs). Additionally, icariin increased bone mass and decreased bone loss in titanium-particle-induced osteolytic sites. Mechanistically, icariin inhibited decreased β-catenin stability induced by titanium particles in vivo and in vitro. To confirm icariin mediated its bone-protective effects via the Wnt/β-catenin signaling pathway, we demonstrated that ICG-001, a selective Wnt/β-catenin inhibitor, attenuated the effects of icariin on MSC mineralization in vitro and bone formation in vivo. Therefore, icariin could induce osteogenic differentiation of MSCs and promote new bone formation at a titanium-particle-induced osteolytic site via activation of the Wnt/β-catenin signaling pathway. These results further support the protective effects of icariin on particle-induced bone loss and provide novel mechanistic insights into the recognized bone-anabolic effects of icariin and an evidence-based rationale for its use in PIO treatment.
Visual adaptation dominates bimodal visual-motor action adaptation
Authors: de la Rosa Stephan , Ferstl Ylva , Bülthoff Heinrich H. 
Published: March 2016

AbstractA long standing debate revolves around the question whether visual action recognition primarily relies on visual or motor action information. Previous studies mainly examined the contribution of either visual or motor information to action recognition. Yet, the interaction of visual and motor action information is particularly important for understanding action recognition in social interactions, where humans often observe and execute actions at the same time. Here, we behaviourally examined the interaction of visual and motor action recognition processes when participants simultaneously observe and execute actions. We took advantage of behavioural action adaptation effects to investigate behavioural correlates of neural action recognition mechanisms. In line with previous results, we find that prolonged visual exposure (visual adaptation) and prolonged execution of the same action with closed eyes (non-visual motor adaptation) influence action recognition. However, when participants simultaneously adapted visually and motorically – akin to simultaneous execution and observation of actions in social interactions - adaptation effects were only modulated by visual but not motor adaptation. Action recognition, therefore, relies primarily on vision-based action recognition mechanisms in situations that require simultaneous action observation and execution, such as social interactions. The results suggest caution when associating social behaviour in social interactions with motor based information.
pH Induced Conformational Transitions in the Transforming Growth Factor β-Induced Protein (TGFβIp) Associated Corneal Dystrophy Mutants
Authors: Murugan Elavazhagan , Venkatraman Anandalakshmi , Lei Zhou , Mouvet Victoria , Rui Yi Lim Rayne , Muruganantham Nandhakumar , Goh Eunice , Swee Lim Peh Gary , Beuerman Roger W. , Chaurasia Shyam S. , Rajamani Lakshminarayanan , Mehta Jodhbir S. 
Published: March 2016

AbstractMost stromal corneal dystrophies are associated with aggregation and deposition of the mutated transforming growth factor-β induced protein (TGFβIp). The 4th_FAS1 domain of TGFβIp harbors ~80% of the mutations that forms amyloidogenic and non-amyloidogenic aggregates. To understand the mechanism of aggregation and the differences between the amyloidogenic and non-amyloidogenic phenotypes, we expressed the 4th_FAS1 domains of TGFβIp carrying the mutations R555W (non-amyloidogenic) and H572R (amyloidogenic) along with the wild-type (WT). R555W was more susceptible to acidic pH compared to H572R and displayed varying chemical stabilities with decreasing pH. Thermal denaturation studies at acidic pH showed that while WT did not undergo any conformational transition, the mutants exhibited a clear pH-dependent irreversible conversion from αβ conformation to β-sheet oligomers. The β-oligomers of both mutants were stable at physiological temperature and pH. Electron microscopy and dynamic light scattering studies showed that β-oligomers of H572R were larger compared to R555W. The β-oligomers of both mutants were cytotoxic to primary human corneal stromal fibroblast (pHCSF) cells. The β-oligomers of both mutants exhibit variations in their morphologies, sizes, thermal and chemical stabilities, aggregation patterns and cytotoxicities.
Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole
Authors: Ariza Adriana , García-Martín Elena , Salas María , Montañez María I. , Mayorga Cristobalina , Blanca-Lopez Natalia , Andreu Inmaculada , Perkins James , Blanca Miguel , Agúndez José A. G. , Torres María J. 
Published: March 2016

AbstractNon-steroidal anti-inflammatory drugs (NSAIDs) are the most common cause of hypersensitivity reactions, with pyrazolones the most frequent drugs inducing selective reactions. Immediate selective hypersensitivity to pyrazolones is thought to be mediated by specific-IgE. Sensitivity ofin vitrodiagnostic tests is low and this may be due to the incomplete characterization of the structures involved. Here we investigated whether main metabolites of metamizole (dipyrone) in human could be involved in the immune response using the basophil activation test (BAT). We studied subjects with confirmed selective immediate hypersensitivity to metamizole and performed BAT with metamizole and its metabolites: 4-methylamino-antipyrine (MAA), 4-aminoantipyrine (AA), 4-acetylamino-antipyrine (AAA) and 4-formylamino-antipyrine (FAA). BAT results showed an increase of positive results from 37.5% to 62.5% using metamizole plus metabolites as compared with the BAT carried out only with the parent drug, demonstrating that metamizole metabolites have a role in the reaction and can induce specific basophil activation in patients with immediate hypersensitivity to this drug. Our findings indicate that pyrazolone metabolites are useful for improving thein vitrodiagnosis of allergic reactions to metamizole.
An in vitro cell irradiation protocol for testing photopharmaceuticals and the effect of blue, green, and red light on human cancer cell lines
Authors: Hopkins S. L. , Siewert B. , Askes S. H. C. , Veldhuizen P. , Zwier R. , Heger Michal , Bonnet Sylvestre 
Published: March 2016

AbstractTraditionally, ultraviolet light (100–400 nm) is considered an exogenous carcinogen while visible light (400–780 nm) is deemed harmless. In this work, a LED irradiation system forin vitrophotocytotoxicity testing is described. The LED irradiation system was developed for testing photopharmaceutical drugs, but was used here to determine the basal level response of human cancer cell lines to visible light of different wavelengths, without any photo(chemo)therapeutic. The effects of blue (455 nm, 10.5 mW cm−2), green (520 nm, 20.9 mW cm−2), and red light (630 nm, 34.4 mW cm−2) irradiation was measured for A375 (human malignant melanoma), A431 (human epidermoid carcinoma), A549 (human lung carcinoma), MCF7 (human mammary gland adenocarcinoma), MDA-MB-231 (human mammary gland adenocarcinoma), and U-87 MG (human glioblastoma-grade IV) cell lines. In response to a blue light dose of 19 J cm−2, three cell lines exhibited a minimal (20%, MDA-MB-231) to moderate (30%, A549 and 60%, A375) reduction in cell viability, compared to dark controls. The other cell lines were not affected. Effective blue light doses that produce a therapeutic response in 50% of the cell population (ED50) compared to dark conditions were found to be 10.9 and 30.5 J cm−2for A375 and A549 cells, respectively. No adverse effects were observed in any of the six cell lines irradiated with a 19 J cm−2dose of 520 nm (green) or 630 nm (red) light. The results demonstrate that blue light irradiation can have an effect on the viability of certain human cancer cell types and controls should be used in photopharmaceutical testing, which uses high-energy (blue or violet) visible light activation.
Incidence, Predictors, and Postoperative Complications of Blood Transfusion in Thoracic and Lumbar Fusion Surgery: An Analysis of 13,695 Patients from the American College of Surgeons National Surgical Quality Improvement Program Database
Authors: Aoude Ahmed , Nooh Anas , Fortin Maryse , Aldebeyan Sultan , Jarzem Peter , Ouellet Jean , Weber Michael H. 
Published: March 2016

Study Design Retrospective cohort study. Objective To identify predictive factors for blood transfusion and associated complications in lumbar and thoracic fusion surgeries. Methods The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was used to identify patients who underwent lumbar or thoracic fusion from 2010 to 2013. Multivariate analysis was used to determine predictive factors and postoperative complications associated with transfusion. Results Out of 13,695 patients, 13,170 had lumbar fusion and 525 had thoracic fusion. The prevalence of transfusion was 31.8% for thoracic and 17.0% for lumbar fusion. The multivariate analysis showed that age between 50 and 60, age between 61 and 70, age > 70, dyspnea, American Society of Anesthesiologists class 3, bleeding disease, multilevel surgery, extended surgical time, return to operation room, and higher preoperative blood urea nitrogen (BUN) were predictors of blood transfusion for lumbar fusion. Multilevel surgery, preoperative BUN, and extended surgical time were predictors of transfusion for thoracic fusion. Patients receiving transfusions who underwent lumbar fusion were more likely to develop wound infection, venous thromboembolism, pulmonary embolism, and myocardial infarction and had longer hospital stay. Patients receiving transfusions who underwent thoracic fusion were more likely to have extended hospital stay. Conclusion This study characterizes incidence, predictors, and postoperative complications associated with blood transfusion in thoracic and lumbar fusion. Pre- and postoperative planning for patients deemed to be at high risk of requiring blood transfusion might reduce postoperative complications in this population.
Toxoplasma Encephalitis in Atypical Hosts at an Academic Cancer Center
Authors: Morjaria Sejal , Epstein David J. , Romero Fabian A. , Taur Ying , Seo Susan K. , Papanicolaou Genovefa A. , Hatzoglou Vaios , Rosenblum Marc , Perales Miguel-Angel , Scordo Michael , Kaltsas Anna 
Published: March 2016

Abstract
Toxoplasma encephalitis is a well recognized complication of acquired immune deficiency syndrome, solid organ transplantation, and allogeneic hematopoietic stem cell transplantation (HSCT). However, patients with hematologic malignancies not treated with allogeneic HSCT may also develop this condition, which requires high clinical suspicion and consideration for prophylactic therapy.
Identification of Bacterial and Viral Codetections With Mycoplasma pneumoniae Using the TaqMan Array Card in Patients Hospitalized With Community-Acquired Pneumonia
Authors: Diaz Maureen H. , Cross Kristen E. , Benitez Alvaro J. , Hicks Lauri A. , Kutty Preeta , Bramley Anna M. , Chappell James D. , Hymas Weston , Patel Anami , Qi Chao , Williams Derek J. , Arnold Sandra R. , Ampofo Krow , Self Wesley H. , Grijalva Carlos G. , Anderson Evan J. , McCullers Jonathan A. , Pavia Andrew T. , Wunderink Richard G. , Edwards Kathryn M. , Jain Seema , Winchell Jonas M. 
Published: March 2016

Abstract
Mycoplasma pneumoniae was detected in a number of patients with community-acquired pneumonia in a recent prospective study. To assess whether other pathogens were also detected in these patients, TaqMan Array Cards were used to test 216 M pneumoniae-positive respiratory specimens for 25 additional viral and bacterial respiratory pathogens. It is interesting to note that 1 or more codetections, predominantly bacterial, were identified in approximately 60% of specimens, with codetections being more common in children.