bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mutant mouse resource and research center (MMRRC) consortium: the US-based public mouse repository system
Authors: Agca Yuksel , Amos-Landgraf James , Araiza Renee , Brennan Jennifer , Carlson Charisse , Ciavatta Dominic , Clary Dave , Franklin Craig , Korf Ian , Lutz Cathleen , Magnuson Terry , de Villena Fernando Pardo-Manuel , Mirochnitchenko Oleg , Patel Samit , Port Dan , Reinholdt Laura , Lloyd K. C. Kent 
Published: September 2024

AbstractNow in its 25th year, the Mutant Mouse Resource and Research Center (MMRRC) consortium continues to serve the United States and international biomedical scientific community as a public repository and distribution archive of laboratory mouse models of human disease for research. Supported by the National Institutes of Health (NIH), the MMRRC consists of 4 regionally distributed and dedicated vivaria, offices, and specialized laboratory facilities and an Informatics Coordination and Service Center (ICSC). The overarching purpose of the MMRRC is to facilitate groundbreaking biomedical research by offering an extensive repertoire of mutant mice that are essential for advancing the understanding of human physiology and disease. The function of the MMRRC is to identify, acquire, evaluate, characterize, cryopreserve, and distribute mutant mouse strains to qualified biomedical investigators around the nation and the globe. Mouse strains accepted from the research community are held to the highest scientific standards to optimize reproducibility and enhance scientific rigor and transparency. All submitted strains are thoroughly reviewed, documented, and validated using extensive scientific quality control measures. In addition, the MMRRC conducts resource-related research on cryopreservation, mouse genetics, environmental conditions, and other topics that enhance operations of the MMRRC. Today, the MMRRC maintains an archive of mice, cryopreserved embryos and sperm, embryonic stem (ES) cell lines, and murine hybridomas for nearly 65,000 alleles. Since its inception, the MMRRC has fulfilled more than 20,000 orders from 13,651 scientists at 8441 institutions worldwide. The MMRRC also provides numerous services to assist researchers, including scientific consultation, technical assistance, genetic assays, microbiome analysis, analytical phenotyping, pathology, cryorecovery, husbandry, breeding and colony management, infectious disease surveillance, and disease modeling. The ICSC coordinates MMRRC operations, interacts with researchers, and manages the website (mmrrc.org) and online catalogue. Researchers benefit from an expansive list of well-defined mouse models of disease that meet the highest scientific standards while submitting investigators benefit by having their mouse strains cryopreserved, protected, and distributed in compliance with NIH policies.
Philosophy and Clinical Reasoning in Rehabilitation Sciences: Bridging the Gap
Authors: Rosa Davide Dalla , Chiffi Daniele , Andreoletti Mattia 
Published: September 2024

AbstractThis paper addresses the relatively overlooked field of rehabilitation and physical medicine, offering an epistemological perspective on clinical reasoning in these disciplines, focusing on three different domains: diagnosis, prognosis, and treatment. Rehabilitation sciences, often overshadowed by medicine and nursing, present unique challenges in terms of clinical reasoning. We explore these challenges, highlighting the distinctive features that set rehabilitation apart from clinical medicine. Notably, rehabilitation focuses on functions, aiming to improve an individual’s quality of life, setting it apart from disease-centered medicine. Drawing also from philosophical insights in nursing literature, we offer a multidisciplinary perspective on the epistemological dimensions of rehabilitation and physical medicine, shedding light on their placement within healthcare disciplines.
Hypertrophic obstructive cardiomyopathy-left ventricular outflow tract shapes and their hemodynamic influences applying CMR
Authors: Mayr T. , Riazy L. , Trauzeddel R. F. , Bassenge J. P. , Wiesemann S. , Blaszczyk E. , Prothmann M. , Hadler T. , Schmitter S. , Schulz-Menger Jeanette 
Published: September 2024

AbstractHypertrophic cardiomyopathy (HCM) is one of the most common genetic cardiac disorders and is characterized by different phenotypes of left ventricular hypertrophy with and without obstruction. The effects of left ventricular outflow tract (LVOT) obstruction based on different anatomies may be hemodynamically relevant and influence therapeutic decision making. Cardiovascular magnetic resonance (CMR) provides anatomical information. We aimed to identify different shapes of LVOT-obstruction using Cardiovascular Magnetic Resonance (CMR). The study consisted of two parts: An in-vivo experiment for shape analysis and in-vitro part for the assessment of its hemodynamic consequences. In-vivo a 3D depiction of the LVOT was created using a 3D multi-slice reconstruction from 2D-slices (full coverage cine stack with 7 slices and a thickness of 5–6 mm with no gap) in 125 consecutive HOCM patients (age = 64.17 +/− 12.655; female n = 42). In-vitro an analysis of the LVOT regarding shape and flow behavior was conducted. For this purpose, 2D and 4D measurements were performed on 3D printed phantoms which were based on the anatomical characteristics of the in-vivo study, retrospectively. The in-vivo study identified three main shapes named K- (28.8%), X- (51.2%) and V-shape (10.4%) and a mixed one (9.6%). By analyzing the in-vitro flow measurements every shape showed an individual flow profile in relation to the maximum velocity in cm/s. Here, the V-shape showed the highest value of velocity (max. 138.87 cm/s). The X-shape was characterized by a similar profile but with lower velocity values (max. 125.39 cm/s), whereas the K-shape had an increase of the velocity without decrease (max. 137.11 cm/s). For the first time three different shapes of LVOT-obstruction could be identified. These variants seem to affect the hemodynamics in HOCM.
“Even When I was on the Street, I Still Didn’t Want to Give Myself the Label of ‘Prostitute’”: Sex Trade Survivor Mentors’ Narrative Constructions of Their Past Involvement in the Sex Trade
Authors: Kali Dodish-Adi , Malka Menny 
Published: September 2024

AbstractWomen involved in the sex trade (WST) often face pathologizing attitudes due to their participation in the sex trade. Their rehabilitation journey is supported by clinical social workers specializing in complex trauma-informed care, as well as Sex Trade Survivor Mentors (STSM), who are supervised by these professionals. Through the lens of social construction theory and the narrative approach, this study sought to delve into the narrative constructions of STSM regarding their past engagement in the Israeli sex trade industry. Based on a qualitative approach, eight STSM were interviewed through a semi-structured, in-depth interview, which was analyzed by content analysis. Results point to three structural narratives in which STSM give meaning to what they described as “the prostitution story”. (1) The dominant story, within which negative meaning was given to the prostitution story, embodying shame, and concealment from the self, from one’s peer group, and in job interviews; (2) the first alternative story, in which, within a semi-professional context, STSM expose the prostitution story on the basis of professional honesty, sowing seeds of hope and creating bonding with street WST; and (3) the second alternative story, in which the prostitution story is exposed in a public-social context, as a story of survival and inspiration. The study’s conclusions advocate for integrating creative and narrative approaches into clinical practice to mitigate the destructive impact of social stigma inherent in the dominant story. Based on the lived experience of WST/STSM, clinical social workers can contribute to the construction of alternative stories, thereby challenging and reshaping the dominant stories.
Reliable decentralized failure diagnosis of discrete event systems using single-level inference
Authors: Hamada Takumi , Takai Shigemasa 
Published: September 2024

AbstractWe consider a reliable decentralized diagnosis problem for discrete event systems in the inference-based framework. This problem requires us to synthesize local diagnosers such that the occurrence of any failure string is correctly detected within a finite number of steps, even if local diagnosis decisions of some local diagnosers are not available. In the case of single-level inference, we introduce a notion of reliable 1-inference-diagnosability and show that reliable 1-inference-diagnosability is a necessary and sufficient condition for the existence of a solution to the reliable decentralized diagnosis problem. Then, we show how to verify reliable 1-inference-diagnosability effectively. When the system to be diagnosed is reliably 1-inference-diagnosable, we compute the delay bound within which the occurrence of any failure string can be detected. Local diagnosers can be constructed using the computed delay bound.
Monitoring and assessment of spatiotemporal soil salinization in the Lake Urmia region
Authors: Mirzaee S. , Nafchi A. Mirzakhani , Ostovari Y. , Seifi M. , Ghorbani-Dashtaki S. , Khodaverdiloo H. , Chakherlou S. , Taghizadeh-Mehrjardi R. , Raei B. 
Published: September 2024

AbstractSoil salinization stands as a prominent global environmental challenge, necessitating enhanced assessment methodologies. This study is dedicated to refining soil salinity assessment in the Lake Urmia region of Iran, utilizing multi-year data spanning from 2015 to 2018. To achieve this objective, soil salinity was measured at 915 sampling points during the 2015–2018 timeframe. Simultaneously, remote sensing data were derived from surface reflectance data over the same study period. Four distinct scenarios were considered such as a newly developed spectral index (Scenario I), the newly developed index combined with other salt-based spectral indices from the literature (Scenario II), indirect spectral indices based on vegetation and soil characteristics (Scenario III), and the amalgamation of both direct and indirect spectral indices (Scenario IV). Linear Regression (LR), Support Vector Machine (SVM), and Random Forest (RF) were employed to assess soil salinity. The measured data divided to 75% of the data as the calibration dataset, while the remaining 25% constituted the validation dataset. The findings revealed a correlation between soil salinity and spectral indices from the literature, with a range of -0.53 to 0.51, while the newly developed spectral index exhibited a stronger correlation (r = 0.59). Furthermore, RF yielded superior results when using the newly developed spectral index (Scenario I). Overall, SVM emerged as the most effective model (ME = -9.678, R2 = 0.751, and RPIQ = 1.78) when integrating direct and indirect spectral indices (Scenario IV). This study demonstrates the efficacy of combining machine learning techniques with a blend of newly developed and existing spectral indices from the literature for the monitoring of soil salinity, particularly in arid and semi-arid regions.
How Darwin can help Post-Structuralists Maintain that Apartheid was Unconditionally Unjust
Authors: van der Merwe Ragnar 
Published: September 2024

AbstractGenerally, we want certain ethical claims to be unconditionally true. One such claim is “Apartheid was unjust”. In this paper, I discuss a group of South African post-structuralist philosophers who call their view Critical Complexity (CC). Because of post-structuralism’s radical contextualism, CCists can only claim that things are ‘as if’ Apartheid was unjust. They cannot claim that Apartheid was unconditionally unjust. Many will find this unsatisfying. I argue that a naturalised or Darwinian notion of rationality can help CCists (and perhaps post-structuralists in general) in this regard. This kind of rationality is what has come to be known as embodied rationality. We employ embodied rationality when navigating the ecological and social domains. It has, though, been co-opted for navigating the ethical domain. We can, then, claim that Apartheid was unconditionally unjust because it is embodied rational to do so. This does not involve embracing the kind of Cartesian rationality that CCists rightly reject.
Will temporarily free bike sharing change transport behavior forever? Evidence from a free rides’ promotion on trip demand
Authors: Weschke Jan 
Published: September 2024

AbstractThe relation between price and transport demand is one of the main aspects of transport mode choice. While price elasticities are well known for conventional transport modes like driving or public transport, only few studies exist dealing with fares and prices for rather new (shared) modes like bike sharing. In particular, hardly no evidence is available on the impact of the usage fee on trip demand for urban bike share systems. Therefore, the present paper develops an empirical approach to estimate the impact of a temporarily introduced 30-day free bike share rides promotion in Boston, MA in summer 2022. Based on daily trip data of bike sharing systems in Boston, MA and Washington, D.C., a difference-in-differences model is estimated to analyze the impact of the free fare. Results show that trip demand rise by up to 55% due to the waived usage fee during the time of the promotion. Furthermore, model results reveal that trip demand stays at a 20% increased level even three months after the end of the fare free program.
Hydrothermal synthesis of bare TiO2 nanowires and polystyrene (PS)-TiO2 nanowires used for selective photocatalytic oxidation of 3-pyridinemethanol in water and PS photodegradation in solid state
Authors: Erol İbrahim , Khamidov Gofur , Efe Esra , Yurdakal Sedat , Palmisano Leonardo 
Published: September 2024

AbstractIn the present work, nanowire (NW) structured TiO2 nanoparticles were prepared using the hydrothermal method and characterized by X-Ray Diffraction (XRD), Scanning Electron Microscope (SEM), and BET specific surface area techniques. They were obtained in the anatase phase and presented a high surface area (ca. 300 m2/g). A commercial TiO2 (anatase, Merck) was used for comparison. The TiO2 catalysts were tested for photocatalytic oxidation of 3-pyridinemethanol to 3-pyridinemethanal and vitamin B3 in water under UVA irradiation. The effects of acid treatment and subsequent calcination for TiO2 catalysts after the hydrothermal synthesis were also investigated. The sample, subjected to acid treatment and calcined at 300 °C (NW-HCl-300), showed the highest photocatalytic activity and selectivity towards the products. Consequently, this sample and Merck TiO2 were used to prepare polystyrene (PS)/TiO2 composites using the hydrothermal method. They were characterized by XRD, SEM–EDX, Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared Spectroscopy (FT-IR), Thermogravimetric analysis (TGA), Differential Scanning Calorimetry (DSC), UV–Vis, Gel Permeation Chromatography (GPC), and contact angle measurements and tested for PS (present in the composite) photodegradation. The results indicated that NW-HCl-300 had a high surface area, and was highly hydroxylated, favouring a good distribution of PS in the composite. The composite presented high thermal stability, but under UVA irradiation the polymer underwent solid-state photocatalytic degradation due to the contact with TiO2. The composite photodegradation was investigated using gravimetric, GPC, FT-IR, UV–Vis, and SEM techniques.
Temporal Counteridentity and Imagining De Nunc
Authors: Pearson Hazel 
Published: September 2024

AbstractIn temporal counteridenticals like ‘Ian is imagining that it is 2030 and Sally is rich’, the subject locates themself at a time other than (what they believe to be) the current time. In such reports, tense in the embedded clause can denote the time that the attitude holder imagines herself to be located at, or the time that she believes herself to be located at. I show that these two interpretations are subject to systematic constraints. The observed pattern is parallel to that discovered in Pearson (in prep.) for personal counteridenticals, such as Lakoff’s famous Brigitte Bardot sentence. I propose an analysis of these findings that depends on two key assumptions: (1) there is a mechanism of ‘de nunc binding’ that encodes the ‘subjective now’ of the attitude holder; and (2) this mechanism is constrained by a principle of the grammar called ‘Condition CW’, originally proposed for personal counteridenticals in Pearson (in prep.). These findings support the view that attitudes de se and de nunc constitute a special class, not reducible to de re. They further suggest that there is a dedicated linguistic mechanism for encoding such attitudes that is subject to systematic grammatical constraints.
Apoptotic Potential of Iloneoside from Gongronema latifolium Benth against Prostate Cancer Cells Using In Vitro and In Silico Approach
Authors: Gyebi Gideon A. , Afolabi Saheed O. , Ogunyemi Oludare M. , Ibrahim Ibrahim M. , Olorundare Olufunke E. , Adebayo Joseph O. , Koketsu Mamoru 
Published: September 2024

Abstract
Prostate cancer is a major cause of cancer-related mortality in men worldwide. The anti-proliferative activity of Gongronema latifolium leaf extracts on some cancer cells has been reported. Herein, we investigated the growth inhibitory effect of the Gongronema latilolium leaf methanol extract and isolated pregnane (iloneoside) against prostate cancer cell lines using the MTT cell proliferation assay, apoptosis quantification, cell cycle analysis using flow cytometry and computational analysis molecular docking, molecular dynamics simulation (MDs), binding free energy computation and cluster analysis. In addition, UPLC-ESI-TOFMS chemical fingerprinting of previously isolated compounds was performed. The extract inhibited the growth of the cell lines with an IC50 of 49.3 µg/ml and 28.4 µg/ml for 24 h and 48 h, respectively, for PC3; and 43.7 µg/ml and 22.3 µg/ml for 24 h and 48 h, respectively, for DU145. Iloneoside demonstrated low inhibitory activities against PC3 and DU145 (IC50 > 80 μM). Apoptotic quantification and cell cycle analysis further showed that iloneoside induced apoptosis in a few cells at a dose of 200 uM. The ensemble-based molecular docking of the iloneoside to BCL-XL and BCL-2 proteins, and docking to MCL-1, BCL-A1 and BFL-1 proteins, respectively, presented binding energies of −7.22 ± 0.5, −8.12 ± 0.55, −7.1, −7.2 and −6.3 kcal/mol, while the MM/PBSA binding free energy was −25.72 ± 7.22 and −27.76 ± 11.32 kcal/mol for BCL-XL and BCL-2 proteins. Furthermore, iloneoside was stable during the 100 ns MDs analysis, while the clustering of the MDs trajectories showed that the interactions were strongly preserved. Iloneoside, in part, or in synergy with other constituents, may be responsible for the antiproliferative activities of the leaf, subject to further investigation.
NRI and SIRI are the optimal combinations for prognostic risk stratification in patients with non-small cell lung cancer after EGFR-TKI therapy
Authors: Liu Xia , Wang Peipei , Liu Guolong 
Published: September 2024

Abstract
Background
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have become the standard treatment for advanced non-small cell lung cancer (NSCLC) with EGFR mutations. However, NSCLC heterogeneity leads to differences in efficacy; thus, potential biomarkers need to be explored to predict the prognosis of patients. Recently, the prognostic importance of pre-treatment malnutrition and systemic inflammatory response in cancer patients has received increasing attention.

Methods
In this study, clinical information from 363 NSCLC patients receiving EGFR-TKI treatment at our clinical center was used for analysis.

Results
High nutritional risk index (NRI) and systemic inflammation response index (SIRI) were significantly associated with poor overall survival (OS) and progression-free survival (PFS) in NSCLC patients (P < 0.05). Importantly, NRI and SIRI were the best combination models for predicting clinical outcomes of NSCLC patients and independent OS and PFS predictors. Moreover, a nomogram model was constructed by combining NRI/SIRI, sex, smoking history, EGFR mutation, TNM stage, and surgery treatment to visually and personally predict the 1-, 2-, 3-, 4-, and 5-year OS of patients with NSCLC. Notably, risk stratification based on the nomogram model was better than that based on the TNM stage.

Conclusion
NRI and SIRI were the best combination models for predicting clinical outcomes of NSCLC patients receiving EGFR-TKI treatment, which may be a novel biomarker for supplement risk stratification in NSCLC patients.
Expansion effect of romiplostim on hematopoietic stem and progenitor cells versus thrombopoietin and eltrombopag
Authors: Tezuka Yuta , Onoda Naoki , Morishima Tatsuya , Sumitomo Yoshiki , Nishii Keigo , Takizawa Hitoshi , Kai Masayuki 
Published: September 2024

AbstractRomiplostim, a thrombopoietin (TPO) receptor agonist, is a clinically approved drug that is clearly effective in reconstituting hematopoiesis in refractory aplastic anemia and　idiopathic thrombocytopenic purpura. However, the mechanism underlying its biological effect is unknown, and its differences from other TPO receptor agonists remain unclear. Therefore, we determined the in vitro expansion effect of romiplostim on human CD34 + hematopoietic stem and progenitor cells (HSPCs) versus recombinant human TPO (rhTPO) and another clinically available drug, eltrombopag. We also performed single-cell RNA-seq to determine effects of romiplostim on CD34 + HSPCs at the molecular level. The maximum expansion effect of romiplostim on total CD34 + cells, CD34 + CD38 + progenitor cells, and CD34 + CD38 − immature cells was comparable to that of rhTPO, but higher than that of eltrombopag, particularly on CD34 + CD38 − immature cells. Single-cell RNA-seq analysis revealed that both romiplostim and eltrombopag induced signatures driven by rhTPO, but romiplostim induced molecular changes related to RHOA signaling in the most primitive HSPC subsets that were partially driven or not driven by eltrombopag. Additionally, romiplostim did not induce TFRC expression as was observed with eltrombopag. In conclusion, romiplostim expands and affects human HSPCs similar to rhTPO, but partially different from eltrombopag in terms of induction of gene expression.
Psychological Stress and Urticaria: Pathophysiologic and Therapeutic Updates
Authors: Xiang Yi-Kui , Türk Murat , Ojeda Ivan Cherrez , Elieh-Ali-Komi Daniel , Salman Andac , Kocatürk Emek 
Published: September 2024

Abstract
Purpose of review
The goal of this review is to examine the relationship between psychological stress and chronic urticaria (CU), focusing on the underlying mechanisms and potential therapeutic interventions. The paper seeks to answer how stress exacerbates CU and the neuro-immunological pathways involved, providing insight into improving therapeutic strategies by considering the psychological dimensions of the disease.

Recent findings
Recent studies highlight the significant role of stress in aggravating CU through the dysregulation of the hypothalamic-pituitary-adrenal axis and neurogenic inflammation. Increased levels of neuropeptides like substance P and calcitonin gene-related peptide, as well as upregulated expression of the MRGPRX2 receptor, are implicated in the neuro-immune interactions that worsen CU symptoms. Additionally, psychological distress has been linked to poorer disease outcomes, with stress management strategies and psychopharmacological interventions showing promise in reducing disease severity.

Summary
This review concludes that stress significantly contributes to the exacerbation of CU through neuro-immune pathways, suggesting the need for holistic treatment approaches. Addressing both the physical and psychological aspects of CU may improve disease management and patient outcomes. Future research should focus on further elucidating the connection between stress and CU and developing targeted therapies that integrate stress reduction techniques into standard care.