bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient/parent perspectives on genomic tumor profiling of pediatric solid tumors: The Individualized Cancer Therapy (iCat) experience
Authors: Marron Jonathan M. , DuBois Steven G. , Bender Julia Glade , Kim AeRang , Crompton Brian D. , Meyer Stephanie C. , Janeway Katherine A. , Mack Jennifer W. 
Published: July 2016

AbstractBackgroundGenomic tumor profiling (GTP) plays an important role in the care of many adult cancer patients. Its role in pediatric oncology is still evolving, with only a subset of patients currently expected to receive clinically significant results. Little is known about perspectives of pediatric oncology patients/parents on GTP.ProcedureWe surveyed individuals who previously underwent GTP through the iCat (Individualized Cancer Therapy) pilot study of molecular profiling in children with relapsed, refractory, and high‐risk solid tumors at four pediatric cancer centers. Following return of profiling results, a cross‐sectional survey was offered to the patient, if he or she was 18 years or older at enrollment, or parent, if he or she was under 18 years of age. Forty‐five surveys (85% response) were completed.ResultsEighty‐nine percent (39/44) of respondents reported hoping participation would help find cures for future patients, while 59% (26/44) hoped it would increase their/their child's chance of cure. Most had few concerns about GTP, but 12% (5/43) worried they would learn their/their child's cancer was less treatable or more aggressive than previously thought. Sixty‐four percent (29/45) reported feeling their participation had helped others and 44% (20/45) felt they had helped themselves/their own child, despite only one substudy subject receiving targeted therapy matched to GTP findings. Fifty‐four percent (21/39) wished to receive all available profiling data, including findings unrelated to cancer and of unclear significance.ConclusionsParticipants in pediatric GTP research perceive benefits of GTP to themselves and others, but expectations of personal benefits of GTP may exceed actual positive impact. These issues warrant consideration during consent discussions about GTP research participation.
Otologic manifestations of Fanconi anemia and other inherited bone marrow failure syndromes
Authors: Kalejaiye Adedoyin , Giri Neelam , Brewer Carmen C. , Zalewski Christopher K. , King Kelly A. , Adams Charleen D. , Rosenberg Philip S. , Kim H. Jeffrey , Alter Blanche P. 
Published: July 2016

AbstractBackgroundThe inherited bone marrow failure syndromes (IBMFSs) are diverse disorders with syndrome‐specific features; their otologic and audiologic manifestations have not been well described. Our objective was to characterize these in patients with Fanconi anemia (FA), dyskeratosis congenita (DC), Diamond–Blackfan anemia (DBA), and Shwachman–Diamond syndrome (SDS), and to determine the association between physical findings and hearing loss.MethodsPatients with an IBMFS underwent comprehensive clinical and laboratory evaluations and testing for syndrome‐specific gene mutations. Hearing loss was measured by pure tone audiometry and otologic abnormalities by otomicroscopy.ResultsPatients included 33 with FA, 37 with DC, 32 with DBA, and nine with SDS. Hearing loss was most frequent in patients with FA (45%) and DBA (14%). The most common type of hearing loss in FA was conductive (65%). Absent or hypoplastic radius, noted in 21% of the patients with FA, was associated with hearing loss in all cases. Otomicroscopy was abnormal in 66% of patients with FA. Characteristic ear abnormalities included small tympanic membrane (66%), malformed malleus (57%), aberrant tympanic bony island (48%), narrow external auditory canal (EAC) (32%), and abnormal course of chorda tympani (34%). Ear malformations were almost always associated with hearing loss. Hearing loss was rare in patients with DC and SDS.ConclusionsFA is the major IBMFS with associated hearing loss, which is most commonly conductive. Radial hypoplasia or aplasia and characteristic congenital ear malformations are associated with hearing loss in patients with FA. Recognition of these syndrome‐specific abnormalities should lead to earlier management of hearing loss.
Religious beliefs and mammography intention: findings from a qualitative study of a diverse group of American Muslim women
Authors: Padela Aasim I. , Vu Milkie , Muhammad Hadiyah , Marfani Farha , Mallick Saleha , Peek Monica , Quinn Michael T. 
Published: July 2016

AbstractObjectiveStudies suggest that American Muslim women underutilize mammography. While religion has a strong influence upon Muslim health behaviors, scant research has examined how religion‐related beliefs inform Muslim women's intention for mammography. Our study identifies and examines such beliefs.MethodsMuslim women aged 40 years and older sampled from mosques participated in focus groups and individual interviews. Drawing upon the theory of planned behavior, interviews elicited salient behavioral, normative, and control beliefs regarding mammography and the influence of Islam upon screening intention.ResultsFifty women participated in 6 focus groups and 19 in semistructured interviews, with near‐equal numbers of African American, South Asian, and Arab Muslims. Forty‐two percent of participants had not had a mammogram within the past 2 years. Across differences in race/ethnicity and mammography status, women voiced four religion‐related salient beliefs that inform mammography intention: (1) the perceived duty to care for one's health, (2) religious practices as methods of disease prevention, (3) fatalistic notions about health, and (4) comfort with gender concordant health care.ConclusionsReligious beliefs influence decisions to pursue mammography across the ethnic/racial diversity of Muslim women. Notions about duty to God and the stewardship of one's body appear to enhance mammography intention. Theocentric notions of cure and illness and varied views regarding personal agency also inform decisional frames that impact mammography intention. Given the salience of religion among our participants, religiously tailored messages in interventions have the potential to enhance cancer screening.
Costs and benefits of insecticide and foliar nutrient applications to huanglongbing‐infected citrus trees
Authors: Tansey James A , Vanaclocha Pilar , Monzo Cesar , Jones Moneen , Stansly Philip A 
Published: July 2016

AbstractBACKGROUNDThe Asian citrus psyllid (ACP), Diaphorina citri Kuwayama (Hemiptera: Psyllidae), vectors Candidatus Liberibacter asiaticus, which causes huanglongbing (HLB). In Florida, HLB incidence is approaching 100% statewide. Yields have decreased and production costs have increased since 2005. Despite this, some growers are maintaining a level of production and attribute this in part to aggressive psyllid control and foliar nutrition sprays. However, the value of these practices is debated. A replicated field study was initiated in 2008 in a commercial block of ‘Valencia’ sweet orange trees to evaluate individual and combined effects of foliar nutrition and ACP control. Results from 2012–2016 are presented.RESULTSInsecticides consistently reduced ACP populations. However, neither insecticide nor nutrition applications significantly influenced HLB incidence or PCR copy number in mature trees. In reset trees, infection continued to build and reached 100% in all treatments. Greatest yields (kg fruit ha−1) and production (kg solids ha−1) were obtained from trees receiving both insecticides and foliar nutrition.CONCLUSIONAll treatments resulted in production and financial gains relative to controls. However, material and application costs associated with the nutrition component offset these gains, resulting in lesser benefits than insecticides applied alone. © 2016 Society of Chemical Industry
On the efficiency of combined ion implantation for the creation of near‐surface nitrogen‐vacancy centers in diamond
Authors: Fávaro de Oliveira Felipe , Momenzadeh Seyed Ali , Antonov Denis , Fedder Helmut , Denisenko Andrej , Wrachtrup Jörg 
Published: July 2016

AbstractThe efficiency of co‐implantation of different ion species to generate near‐surface nitrogen‐vacancy (NV) centers in diamond is analyzed by comparing the areal densities of NV centers corresponding to various experimental conditions. In particular, the effect of helium (6keV ) and carbon (10keV ) co‐implantation within a wide range of ion fluences are studied. The total density of NV centers by co‐implantation are shown to be basically a sum of the nitrogen‐induced NV centers and those activated from residual nitrogen impurities present in the substrate (approximately 1ppb) by the excess of vacancies at the carbon‐ and helium‐induced ion tracks. Such low efficiency of the co‐implantation events is discussed considering the model of local clusters of vacancies at each implantation‐induced ion track. This is also experimentally supported by the presence of a photoluminescence (PL) background related to radiation‐induced defects measured within all implanted areas with high carbon and helium ion fluences. Further limits set by the annealing temperature are also discussed.
Efficient synthesis and tailoring of magnetic and dielectric properties of Pb‐free perovskite‐like ABX3 metal‐organic frameworks
Authors: Abhyankar Nandita , Lee Minseong , Foley Megan , Choi Eun Sang , Strouse Geoffrey , Kroto Harold W. , Dalal Naresh S. 
Published: July 2016

Perovskite‐like metal‐organic frameworks (MOFs) are hybrid materials of high interest for their potential in information storage technology, as Pb‐free substitutes for the widely used lead zirconate titanate (PZT) family of multiferroics. We report here a new, microwave‐assisted method of synthesis for perovskite‐like MOFs, which exploits the advantages of rapid and volumetric heating by microwaves in order to achieve synthesis within minutes, compared to days required by previously reported methods. The preliminary results demonstrate a broad control over the size and morphology of the products, by minor changes in the reaction conditions. An investigation of the effects of size and morphology on the magnetic and dielectric properties is presented here.
magnified image (© 2016 WILEY‐VCH Verlag GmbH &Co. KGaA, Weinheim)
Simulation of Climate Change Effects on Hydropower Operations in Mountain Headwater Lakes, New Zealand
Authors: Caruso B. S. , King R. , Newton S. , Zammit C. 
Published: July 2016

AbstractFuture climate change is expected to have wide ranging impacts on the hydrology of mountain rivers because of changes in the magnitudes and timing of rain and snow, as well as the significant spatial variability of topography and other catchment characteristics. In New Zealand, hydropower generation in mountain basins is the primary source of electricity and renewable energy resource in the country. The goal of this study was to simulate and evaluate the potential effects of climate change on hydropower operations in three mountain headwater lakes (lakes Pukaki, Tekapo, and Ohau) in the Upper Waitaki Basin of the central South Island. The TopNet hydrological model was used to estimate catchment runoff and lake inflows based on the 1990s (baseline), 2040s, and 2090s periods. Average temperature and precipitation results from an ensemble of 12 Global Circulation Models based on the IPCC 4th Assessment Report A1B emissions scenario were used as input to TopNet. Linked hydropower lake water balance models were developed and used to simulate hydropower operations including discharge, hydroelectric power generation, and spill based on TopNet future inflow predictions, projected electricity demand, and lake storage and outflow characteristics. Our results indicate that annual lake inflows increase under future climate scenarios, but that there are seasonal effects with increasing flows in winter and early spring, and summer flows decreasing somewhat as a result of increasing temperatures and greater winter rain with less snow. Although overall hydropower generation can increase with the increasing flows and projected electricity demand, the seasonal changes result in demand being met in winter and spring with potential shortfalls in summer and autumn. Maximum annual generation can be achieved for some generating stations, but generation will decrease at other stations and more spill will likely be required through the 2090s because of the seasonal changes. Therefore flood and drought risk could also increase for downstream areas. Results also indicate that by the 2090s electricity demand could exceed generation capacity for these headwater lakes. Copyright © 2016 John Wiley & Sons, Ltd.
Odyssey in Polyphasic Catalysis by Metal Nanoparticles
Authors: Denicourt‐Nowicki Audrey , Roucoux Alain 
Published: July 2016

AbstractNanometer‐sized metal particles constitute an unavoidable family of catalysts, combining the advantages of molecular complexes in regards to their catalytic performances and the ones of heterogeneous systems in terms of easy recycling. As part of this research, our group aims at designing well‐defined metal nanoparticles based‐catalysts, in non‐conventional media (ionic liquids or water), for various catalytic applications (hydrogenation, dehalogenation, carbon‐carbon coupling, asymmetric catalysis) in mild reaction conditions. In the drive towards a more eco‐responsible chemistry, the main focuses rely on the search of highly active and selective nanocatalysts, in association with an efficient recycling mainly under pure biphasic liquid‐liquid conditions. In this Personal Account, we proposed our almost fifteen‐years odyssey in the world of metal nanoparticles for a sustainable catalysis.
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Visual sign phonology: insights into human reading and language from a natural soundless phonology
Authors: Petitto L. A. , Langdon C. , Stone A. , Andriola D. , Kartheiser G. , Cochran C. 
Published: July 2016

Among the most prevailing assumptions in science and society about the human reading process is that sound and sound‐based phonology are critical to young readers. The child's sound‐to‐letter decoding is viewed as universal and vital to deriving meaning from print. We offer a different view. The crucial link for early reading success is not between segmental sounds and print. Instead the human brain's capacity to segment, categorize, and discern linguistic patterning makes possible the capacity to segment all languages. This biological process includes the segmentation of languages on the hands in signed languages. Exposure to natural sign language in early life equally affords the child's discovery of silent segmental units in visual sign phonology (VSP) that can also facilitate segmental decoding of print. We consider powerful biological evidence about the brain, how it builds sound and sign phonology, and why sound and sign phonology are equally important in language learning and reading. We offer a testable theoretical account, reading model, and predictions about how VSP can facilitate segmentation and mapping between print and meaning. We explain how VSP can be a powerful facilitator of all children's reading success (deaf and hearing)—an account with profound transformative impact on learning to read in deaf children with different language backgrounds. The existence of VSP has important implications for understanding core properties of all human language and reading, challenges assumptions about language and reading as being tied to sound, and provides novel insight into a remarkable biological equivalence in signed and spoken languages. WIREs Cogn Sci 2016, 7:366‐381. doi: 10.1002/wcs.1404This article is categorized under:

Psychology > Language
Clinicopathological Features of Ganglioneuroma Originating From the Adrenal Glands
Authors: Lee Joon‐Hyop , Chai Young Jun , Kim Tae‐Hyung , Choi June Young , Lee Kyu Eun , Kim Hyun‐Young , Yoon Yoo‐Seok , Kim Hyeon Hoe 
Published: July 2016

AbstractBackgroundGanglioneuromas are benign tumors that rarely develop from adrenal glands. In this study, we present our clinical experience of patients with adrenal ganglioneuroma (AGN).MethodsDemographic, diagnostic, surgical, and pathologic findings of patients who were adrenalectomized as a result of AGN were retrospectively reviewed from the database of a tertiary referral hospital.ResultsAmong 1784 patients who underwent an adrenalectomy between 2002 and 2015, 35 (1.9 %; 14 males, 21 females) were diagnosed with AGN. Mean age was 33.4 ± 18.7 years (0–84). Twenty‐nine (82.9 %) were asymptomatic, four (11.4 %) complained of abdominal discomfort, and two (5.7 %) had abdominal distension. Preoperative computed tomography (CT) reported AGN in 22 (62.9 %) cases. Precontrast Hounsfield units, increased postcontrast phase attenuation, and well‐defined borders were characteristic CT features of AGN. Mean tumor size was 6.3 ± 3.3 cm (range, 1.5–16.0). No recurrence occurred during a median follow‐up period of 19 months (range, 1–120).ConclusionAGN was asymptomatic in most cases and diagnosis may be challenging. Adrenalectomy is a safe treatment modality for AGN and ensures favorable outcomes when diagnosed.
Compliance of Clinical Pathways in Elective Laparoscopic Cholecystectomy: Evaluation of Different Implementation Methods
Authors: Holderried Martin , Hummel Rebecca , Falch Claudius , Kirschniak Andreas , Koenigsrainer Alfred , Ernst Christian , Muller Sven 
Published: July 2016

AbstractBackgroundClinical pathways aim to standardize perioperative and postoperative care of surgical procedures and are shown to result in a significant optimization associated with cost reduction. The aim of this study was to establish the impact of two different implementations forms of clinical pathways on the pathway compliance and resulting costs.MethodsData of patients undergoing elective cholecystectomy for symptomatic cholecystolithiasis were collected over two different periods: using a clinical pathway in the form of a paper‐based checklist, or a clinical pathway integrated into the paper‐based medical treatment and nursing documentation. Outcome measures were compliance of the clinical pathway and total costs per case.ResultsThe compliance was significantly higher using integrated pathways compared to paper‐based checklists (n = 117 of 123, 95 % vs 54 of 118, 46 %; p < 0.001). Mean total costs (€2206 vs €2458, p = 0.027) and length of hospital stay (2.13 vs 2.77 days, p < 0.001) were significantly reduced by the integrated clinical pathway compared to checklists. Further, the variation of costs per case and variation of length of hospital stay were significantly smaller with integrated clinical pathway (±€440 vs ±€538, p = 0.039 and ±0.53 vs ±0.68 days, p < 0.001, respectively). No difference regarding postoperative complication was observed (n = 3 vs. 4 events; p = 0.67).ConclusionIntegrated clinical pathways display a significant higher compliance compared to checklists resulting in reduced total costs, shorter hospital stay and a smaller variation of cost, making it a useful tool in process controlling and planning.
Teamwork of clinical teachers in postgraduate medical training
Authors: Slootweg Irene Arida 
Published: July 2016

Teamwork among clinical teachers is essential for continuous improvement of postgraduate medical training. This thesis deconstructs teamwork in four studies, mostly based on qualitative research approaches and one study utilizes mixed methods. We found that clinical teachers do train residents, but individually rather than as a team. The programme directors as leaders focus more on teaching activities than on the collective ambition and mutual engagement of clinical teachers. During the teaching meetings, mistakes and conflicts are mainly discussed in a general sense and are often neither directed at the individual, nor result-oriented. A valid evaluation instrument is constructed to improve teamwork.
Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population‐based elderly cohort
Authors: Dage Jeffrey L. , Wennberg Alexandra M.V. , Airey David C. , Hagen Clinton E. , Knopman David S. , Machulda Mary M. , Roberts Rosebud O. , Jack Clifford R. , Petersen Ronald C. , Mielke Michelle M. 
Published: July 2016

AbstractIntroductionTau protein levels in plasma may be a marker of neuronal damage. We examined associations between plasma tau levels and Alzheimer's disease (AD)–related magnetic resonance imaging (MRI) and positron emission tomography (PET) neuroimaging measures among nondemented individuals.MethodsParticipants included 378 cognitively normal (CN) and 161 mild cognitive impairment (MCI) individuals enrolled in the Mayo Clinic Study of Aging with concurrent neuropsychological measures and amyloid PET, fluorodeoxyglucose PET, and MRI. Baseline plasma tau levels were measured using the Quanterix Simoa‐HD1 tau assay.ResultsPlasma tau levels were higher in MCI compared with CN (4.34 vs. 4.14 pg/mL, P = .078). In regression models adjusted for age, gender, education, and APOE, higher plasma tau was associated with worse memory performance (b = −0.30, P = .02) and abnormal cortical thickness in an AD signature region (odds ratio = 1.80, P = .018).DiscussionPlasma tau is associated with cortical thickness and memory performance. Longitudinal studies will better elucidate the associations between plasma tau, neurodegeneration, and cognition.
Medical Management of Parkinson’s Disease after Initiation of Deep Brain Stimulation
Authors: Fasano Alfonso , Appel-Cresswell Silke , Jog Mandar , Zurowkski Mateusz , Duff-Canning Sarah , Cohn Melanie , Picillo Marina , Honey Christopher R. , Panisset Michel , Munhoz Renato Puppi 
Published: July 2016

AbstractIn this review, we have gathered all the available evidence to guide medication management after deep brain stimulation (DBS) in Parkinson’s disease (PD). Surprisingly, we found that almost no study addressed drug-based management in the postoperative period. Dopaminergic medications are usually reduced, but whether the levodopa or dopamine agonist is to be reduced is left to the personal preference of the treating physician. We have summarized the pros and cons of both approaches. No study on the management of cognitive problems after DBS has been done, and only a few studies have explored the pharmacological management of such DBS-resistant symptoms as voice (amantadine), balance (donepezil) or gait disorders (amantadine, methylphenidate). As for the psychiatric problems so frequently reported in PD patients, researchers have directed their attention to the complex interplay between stimulation and reduction of dopaminergic drugs only recently. In conclusion, studies addressing medical management following DBS are still needed and will certainly contribute to the ultimate success of DBS procedures.
Sustainable Development of Human Resources Inspired by Chinese Philosophies: A Repositioning Based on François Jullien's Works
Authors: Persson Sybille , Shrivastava Paul 
Published: July 2016

ABSTRACTThis paper provides a philosophical repositioning of human resource management (HRM) to further sustainable human resources development (HRD). We use a conceptual process, based on the work of French philosopher and Sinologist François Jullien. Despite its growing and diversified academic production, HRM research has become increasingly isolated from practice, from alternative views of human life, and from nature. This is at least partly due to its failure to self-question its Western centric roots. This paper describes some key conceptual innovations that deal with efficacy and ‘vital nourishment’ which are of particular interest for sustainable HRD. The question of how to feed life (or nourish it) in the workplace is illustrated by a gardening metaphor for managing human potential. In contrast to cross-cultural studies, this metaphor emerges from a dialogue between Western and Eastern philosophies, and offers alternative approaches to HRD based on some core insights from the Chinese tradition.