bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative N-terminal pro-B-type natriuretic peptide concertation and prognosis of brain tumor patients: a 5-year follow up study
Authors: Bunevicius Adomas , Deltuva Vytenis , Laws Edward R. , Iervasi Giorgio , Tamsauskas Arimantas , Bunevicius Robertas 
Published: November 2017

AbstractIncreased N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration predicts poor prognosis of non-CNS cancer patients. We evaluated the association of NT-proBNP concentration with disease severity, discharge outcomes and prognosis of patients undergoing craniotomy for brain tumor. From January, 2010 until September, 2011 two-hundred and forty-five patients (age 55.05 ± 14.62 years) admitted for brain tumor surgery were evaluated for NT-proBNP serum concentration. Outcome at hospital discharge was evaluated with the Glasgow Outcome Scale (GOS). Most common diagnoses were meningioma (37%) and high-grade glioma (20%). Greater NT-proBNP concentration was associated with lower Barthel index (rho = −0.305, p = 0.001) and Mini Mental State Examination scores (rho = −0.314, p = 0.001) and with greater Hospital Anxiety and Depression scale Depression score (rho = 0.240, p = 0.026). Greater admission NT-proBNP concentration was associated with lower discharge GOS score after adjusting for patient age, gender and histological brain tumor diagnosis (β = −0.253, p < 0.001). Greater NT-proBNP concentration was also associated with greater 5-year mortality risk (HR = 1.845; 95%CI [1.166–2.920], p = 0.009) controlling for patient age, gender, history of cardiovascular disease, histological diagnosis and adjuvant therapy. In sum, greater pre-operative NT-proBNP concentration is associated with worse health status, unfavorable discharge outcome and shorter survival of brain tumor patients.
Quantum Light in Curved Low Dimensional Hexagonal Boron Nitride Systems
Authors: Chejanovsky Nathan , Kim Youngwook , Zappe Andrea , Stuhlhofer Benjamin , Taniguchi Takashi , Watanabe Kenji , Dasari Durga , Finkler Amit , Smet Jurgen H. , Wrachtrup Jörg 
Published: November 2017

AbstractLow-dimensional wide bandgap semiconductors open a new playing field in quantum optics using sub-bandgap excitation. In this field, hexagonal boron nitride (h-BN) has been reported to host single quantum emitters (QEs), linking QE density to perimeters. Furthermore, curvature/perimeters in transition metal dichalcogenides (TMDCs) have demonstrated a key role in QE formation. We investigate a curvature-abundant BN system – quasi one-dimensional BN nanotubes (BNNTs) fabricated via a catalyst-free method. We find that non-treated BNNT is an abundant source of stable QEs and analyze their emission features down to single nanotubes, comparing dispersed/suspended material. Combining high spatial resolution of a scanning electron microscope, we categorize and pin-point emission origin to a scale of less than 20 nm, giving us a one-to-one validation of emission source with dimensions smaller than the laser excitation wavelength, elucidating nano-antenna effects. Two emission origins emerge: hybrid/entwined BNNT. By artificially curving h-BN flakes, similar QE spectral features are observed. The impact on emission of solvents used in commercial products and curved regions is also demonstrated. The ‘out of the box’ availability of QEs in BNNT, lacking processing contamination, is a milestone for unraveling their atomic features. These findings open possibilities for precision engineering of QEs, puts h-BN under a similar ‘umbrella’ of TMDC’s QEs and provides a model explaining QEs spatial localization/formation using electron/ion irradiation and chemical etching.
High mast cell density indicates a longer overall survival in oral squamous cell carcinoma
Authors: Brockmeyer Phillipp , Kling Alexander , Schulz Xenia , Perske Christina , Schliephake Henning , Hemmerlein Bernhard 
Published: November 2017

AbstractThis study evaluates the effects of tumour-associated mast cells on the prognosis of patients suffering from oral squamous cell carcinoma (OSCC). Tryptase-positive (MCT+) and CD117-positive (CD117+) mast cells were immunohistochemically evaluated in tissue samples of 118 OSCC patients. Besides, various clinicopathological parameters, the influence of the MCT+ and CD117+ mast cell density on overall survival and the incidence of first local recurrence was analysed by Cox regression and competing risk regression. Among all investigated parameters, multiple Cox regression revealed a significant influence of the MCT+ (cut-off at 14.87 mast cells/mm2 stroma; p = 0.0027) and CD117+ mast cell density (cut-off at 33.19 mast cells/mm2 stroma; p = 0.004), the age at primary diagnosis, and the T and N stage (all p-values < 0.05) on overall survival. Patients with a low mast cell density showed a significantly poorer overall survival rate compared to those with a high mast cell density in the tumour-associated stroma. Competing risk regression revealed a significant influence of the resection status (R) on the incidence of first local recurrence (p = 0.0023). A high mast cell density in the tumour-associated stroma of oral squamous cell carcinoma indicates a longer patient survival.
Peak load forecasting based on multi‐source data and day‐to‐day topological network
Authors: Zeng Pan , Jin Min 
Published: November 2017

Electric load variation results from a variety of factors. This study discusses the inner mechanism of load variation and presents a load forecasting method based on multi‐source data and day‐to‐day topological network. Multi‐source data including weather data, seasonal attributes, calendar attributes, holiday attributes and load growth rate are considered to be the dominant factors that cause the load variation. Initially, a day‐to‐day topological network is generated that reflects the similarity between any 2 days. Additionally, the random walk with restart (RWR) algorithm is applied to the topological network to construct the training set. The support vector regression model is then adopted. With case studies using the data of Guangzhou, the authors obtain a decrease of the mean absolute percentage errors of 19.5 and 25.7% over the SV machine method and a neural network ensemble model. Their research reveals three points: (i) weather elements, especially temperature, air pressure and water vapour pressure, have a dominant influence on load variation besides historical load; (ii) multi‐source data improves the accuracy, meanwhile the applying of RWR algorithm maximises its effect; and (iii) since some of the factors that cause a constant error remains unknown, they can use the feedforward correction to decrease the affects.
Combinatorial approximation of maximum k-vertex cover in bipartite graphs within ratio 0.7
Authors: Paschos Vangelis Th. 
Published: November 2017

We propose and analyze a simple purely combinatorial algorithm for max k-vertex cover in bipartite graphs, achieving approximation ratio 0.7. The only combinatorial algorithm currently known until now for this problem is the natural greedy algorithm, that achieves ratio (e − 1)/e = 0.632.
Modified One-Piece Extended Transbasal Approach for Endoscopic-Assisted Microsurgical Resection of Tuberculum Sellae Meningioma: Operative Video and Technical Nuances
Authors: Liu James , Watanabe Kentaro 
Published: November 2017

AbstractThe optimal approach for surgical resection of tuberculum sellae meningiomas remains controversial. Approach selection is largely based on a variety of factors, such as tumor size, extent and location relative to the optic canal and internal carotid artery, the presence of vascular encasement, and surgeon's preference. In this operative video manuscript, the authors demonstrate the importance of an open transcranial approach when the tumor extends lateral to the optic nerve over the internal carotid artery into the opticocarotid triangle, which is a difficult region to safely access with a purely endoscopic endonasal approach. We present a case of an endoscopic-assisted microsurgical resection of a tuberculum sellae meningioma using a modified one-piece extended transbasal approach in a patient with unilateral visual loss. The approach allows both interhemispheric and subfrontal routes to the suprasellar region. Early optic nerve decompression and division of the falciform ligament is critical to optimize visual outcomes. This video atlas demonstrates the operative technique and surgical nuances of the skull base approach, optic nerve decompression, tumor-arachnoid dissection, and safe handling of the neurovascular structures. A gross total resection was achieved and the patient had restoration of normal vision with normal pituitary function. In summary, the modified one-piece extended transbasal approach with endoscopic assistance is an important strategy in the armamentarium for surgical management of tuberculum sellae meningiomas.The link to the video can be found at: https://www.youtube.com/watch?v=jKNtRzMSFVE.
Changing Trends in the Management of Esthesioneuroblastoma: Irish and International Perspectives
Authors: Subramaniam Thavakumar , Leader Mary , McConn-Walsh Rory , O'Neill James , Lacy Peter , Woods Robbie 
Published: November 2017

Objectives Evaluation of the changing trends in esthesioneuroblastoma in an Irish context and review of management options nationally to clarify the best current therapeutic approach by comparing with international research on this uncommon malignancy.
Design Retrospective review.
Setting Tertiary referral center.
Participants All patients presenting with esthesioneuroblastoma in Beaumont hospital or on the National Cancer Registry of Ireland between 1994 and 2013.
Main Outcome Measures Recurrence-free and overall survival.
Results During the study period, 32 cases of esthesioneuroblastoma were diagnosed (0.4 per million per year). Average age at diagnosis was 57 years; however, two cases were under 20. The majority (62.5%) were male. Patients predominantly presented with epistaxis or nasal congestion (73%), while two cases were identified incidentally on radiological investigations. Twenty-seven cases underwent primary surgical management (two post neo-adjuvant treatment) with seventeen requiring bifrontal craniotomy. Twenty-four of these received postoperative radiation therapy. Overall, 5-year survival was 65%. Kadish A/B patients exhibited 100% 5-year disease-specific survival versus 54% in Kadish C/D (p = 0.011). Hyams grade I/II patients exhibited 75% 5-year disease-specific survival versus 63% in Hyams grade III/IV (p = 0.005). Patients treated endoscopically exhibited 100% 5-year disease-specific survival versus 51% in those treated via an open approach (p = 0.102).
Conclusions Many controversies exist in the diagnosis and management of this condition. Despite this, results from Irish data are mostly concordant with the international literature. The rising incidence of this disease may represent improved pathological recognition. An increasing number of esthesioneuroblastoma cases are being successfully treated via endoscopic surgery.
Changes in Movements of Chinook Salmon between Lakes Huron and Michigan after Alewife Population Collapse
Authors: Clark Richard D. , Bence James R. , Claramunt Randall M. , Clevenger John A. , Kornis Matthew S. , Bronte Charles R. , Madenjian Charles P. , Roseman Edward F. 
Published: November 2017

Abstract
Alewives Alosa pseudoharengus are the preferred food of Chinook Salmon Oncorhynchus tshawytscha in the Laurentian Great Lakes. Alewife populations collapsed in Lake Huron in 2003 but remained comparatively abundant in Lake Michigan. We analyzed capture locations of coded-wire-tagged Chinook Salmon before, during, and after Alewife collapse (1993–2014). We contrasted the pattern of tag recoveries for Chinook Salmon released at the Swan River in northern Lake Huron and Medusa Creek in northern Lake Michigan. We examined patterns during April–July, when Chinook Salmon were primarily occupied by feeding, and August–October, when the salmon were primarily occupied by spawning. We found evidence that Swan River fish shifted their feeding location from Lake Huron to Lake Michigan after the collapse. Over years, proportions of Swan River Chinook Salmon captured in Lake Michigan increased in correspondence with the Alewife decline in Lake Huron. Mean proportions of Swan River fish captured in Lake Michigan were 0.13 (SD = 0.14) before collapse (1993–1997) and 0.82 (SD = 0.22) after collapse (2008–2014) and were significantly different. In contrast, proportions of Medusa Creek fish captured in Lake Michigan did not change; means were 0.98 (SD = 0.05) before collapse and 0.99 (SD = 0.01) after collapse. The mean distance to the center of the coastal distribution of Swan River fish during April–July shifted 357 km (SD = 169) from central Lake Huron before collapse to central Lake Michigan after collapse. The coastal distributions during August–October were centered on the respective sites of origin, suggesting that Chinook Salmon returned to release sites to spawn regardless of their feeding locations. Regarding the impact on Alewife populations, this shift in interlake movement would be equivalent to increasing the Chinook Salmon stocking rate within Lake Michigan by 30%. The primary management implication is that interlake coordination of Chinook Salmon stocking policies would be expected to benefit the recreational fishery.
Received August 26, 2017; accepted September 4, 2017 Published online November 1, 2017
Tripterygium regelii decreases the biosynthesis of triacylglycerol and cholesterol in HepG2 cells
Authors: Kang Myung-Ji , Kwon Eun-Bin , Yuk Heung Joo , Ryu Hyung Won , Kim Soo-Yeon , Lee Mi-Kyeong , Moon Dong-Oh , Lee Su Ui , Oh Sei-Ryang , Lee Hyun-Sun , Kim Mun-Ock 
Published: November 2017

Abstract
In the course of screening to find a plant material decreasing the activity of triacylglycerol and cholesterol, we identified Tripterygium regelii (TR). The methanol extract of TR leaves (TR-LM) was shown to reduce the intracellular lipid contents consisting of triacylglycerol (TG) and cholesterol in HepG2 cells. TR-LM also downregulated the mRNA and protein expression of the lipogenic genes such as SREBP-1 and its target enzymes. Consequently, TR-LM reduced the TG biosynthesis in HepG2 cells. In addition, TR-LM decreased SREBP2 and its target enzyme HMG-CoA reductase, which is involved in cholesterol synthesis. In this study, we evaluated that TR-LM attenuated cellular lipid contents through the suppression of de novo TG and cholesterol biosynthesis in HepG2 cells. All these taken together, TR-LM could be beneficial in regulating lipid metabolism and useful preventing the hyperlipidemia and its complications, in that liver is a crucial tissue for the secretion of serum lipids.
ViraPipe: scalable parallel pipeline for viral metagenome analysis from next generation sequencing reads
Authors: Maarala Altti Ilari , Bzhalava Zurab , Dillner Joakim , Heljanko Keijo , Bzhalava Davit 
Published: November 2017

AbstractMotivationNext Generation Sequencing (NGS) technology enables identification of microbial genomes from massive amount of human microbiomes more rapidly and cheaper than ever before. However, the traditional sequential genome analysis algorithms, tools, and platforms are inefficient for performing large-scale metagenomic studies on ever-growing sample data volumes. Currently, there is an urgent need for scalable analysis pipelines that enable harnessing all the power of parallel computation in computing clusters and in cloud computing environments. We propose ViraPipe, a scalable metagenome analysis pipeline that is able to analyze thousands of human microbiomes in parallel in tolerable time. The pipeline is tuned for analyzing viral metagenomes and the software is applicable for other metagenomic analyses as well. ViraPipe integrates parallel BWA-MEM read aligner, MegaHit De novo assembler, and BLAST and HMMER3 sequence search tools. We show the scalability of ViraPipe by running experiments on mining virus related genomes from NGS datasets in a distributed Spark computing cluster.ResultsViraPipe analyses 768 human samples in 210 minutes on a Spark computing cluster comprising 23 nodes and 1288 cores in total. The speedup of ViraPipe executed on 23 nodes was 11x compared to the sequential analysis pipeline executed on a single node. The whole process includes parallel decompression, read interleaving, BWA-MEM read alignment, filtering and normalizing of non-human reads, De novo contigs assembling, and searching of sequences with BLAST and HMMER3 tools.Availability and implementationhttps://github.com/NGSeq/ViraPipe
DFAST: a flexible prokaryotic genome annotation pipeline for faster genome publication
Authors: Tanizawa Yasuhiro , Fujisawa Takatomo , Nakamura Yasukazu 
Published: November 2017

Abstract

Summary
We developed a prokaryotic genome annotation pipeline, DFAST, that also supports genome submission to public sequence databases. DFAST was originally started as an on-line annotation server, and to date, over 7000 jobs have been processed since its first launch in 2016. Here, we present a newly implemented background annotation engine for DFAST, which is also available as a standalone command-line program. The new engine can annotate a typical-sized bacterial genome within 10 min, with rich information such as pseudogenes, translation exceptions and orthologous gene assignment between given reference genomes. In addition, the modular framework of DFAST allows users to customize the annotation workflow easily and will also facilitate extensions for new functions and incorporation of new tools in the future.

Availability and implementation
The software is implemented in Python 3 and runs in both Python 2.7 and 3.4—on Macintosh and Linux systems. It is freely available at https://github.com/nigyta/dfast_core/under the GPLv3 license with external binaries bundled in the software distribution. An on-line version is also available at https://dfast.nig.ac.jp/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Infinitely Many Solutions for Centro-affine Minkowski Problem
Authors: Li Qi-Rui 
Published: November 2017

Abstract
We study the multiplicity result for the centro-affine Minkowski problem. It is well-known that all ellipsoids with constant volume have the same centro-affine curvature. In this article, we construct a positive, Hölder continuous function $f\in C^\alpha (\mathbb S^n)$ such that there are infinitely many $C^{2,\alpha}$ hypersurfaces which are not affine-equivalent, but have the same centro-affine curvature $1/f$.
On the stability and maximum mass of differentially rotating relativistic stars
Authors: Weih Lukas R , Most Elias R , Rezzolla Luciano 
Published: November 2017

Abstract
The stability properties of rotating relativistic stars against prompt gravitational collapse to a black hole are rather well understood for uniformly rotating models. This is not the case for differentially rotating neutron stars, which are expected to be produced in catastrophic events such as the merger of binary system of neutron stars or the collapse of a massive stellar core. We consider sequences of differentially rotating equilibrium models using the j-constant law and by combining them with their dynamical evolution, we show that a sufficient stability criterion for differentially rotating neutron stars exists similar to the one of their uniformly rotating counterparts. Namely: along a sequence of constant angular momentum, a dynamical instability sets in for central rest-mass densities slightly below the one of the equilibrium solution at the turning point. In addition, following Breu & Rezzolla, we show that ‘quasi-universal’ relations can be found when calculating the turning-point mass. In turn, this allows us to compute the maximum mass allowed by differential rotation, Mmax,dr, in terms of the maximum mass of the non-rotating configuration, $M_{_{\rm TOV}}$, finding that $M_{\rm max, dr} \simeq \left(1.54 \pm 0.05\right) M_{_{\rm TOV}}$ for all the equations of state we have considered.
Commentary: Giuseppe Campani (1635-1715, Rome, Italy): the First Use of a Microscope in Medicine and Surgery
Authors: Brogna Christian , Millesi Matthias , Fiengo Leslie , Richardson Mark , Bhangoo Ranjeev , Ashkan Keyoumars , Türe Uğur 
Published: November 2017

Abstract
Giuseppe Campani (1635-1715) was a polymath in Rome, Italy, during the Scientific Revolution in the XVIIth century. In particular, he forged the screw barrel microscope and was manufacturing his own lenses for microscopes and telescopes. He mastered the art of lens grinding. Those lenses have been analyzed with modern methods and turned out to be of extremely good quality, shining light on the fact that Giuseppe Campani mastered the theories of optics. Moreover, in a letter that Giuseppe Campani sent to Pope Innocent XI, he clearly described the use of a microscope for the examination of wounds of legs. This letter dates back to 15 August 1686 and is the first evidence of the use of microscopes to analyze wounds, sores, and anatomic specimens in medical and surgical settings. MG Yasargil previously showed the lithography accompanying this letter and was the first to recognize its great importance. We accessed this original letter in the Vatican Library, and for the first time we have translated it from Latin to English in order to unveil its significance in the context of the Scientific Revolution and the history of medicine and surgery.
Effects of Cerebral Blood Flow and Vessel Conditions on Speech Recognition in Patients With Postlingual Adult Cochlear Implant: Predictable Factors for the Efficacy of Cochlear Implant
Authors: Ishino Takashi , Ragaee Mahmoud Ali , Maruhashi Tatsuya , Kajikawa Masato , Higashi Yukihito , Sonoyama Toru , Takeno Sachio , Hirakawa Katsuhiro 
Published: November 2017

Objectives:
Cochlear implantation (CI) has been the most successful procedure for restoring hearing in a patient with severe and profound hearing loss. However, possibly owing to the variable brain functions of each patient, its performance and the associated patient satisfaction are widely variable. The authors hypothesize that peripheral and cerebral circulation can be assessed by noninvasive and globally available methods, yielding superior presurgical predictive factors of the performance of CI in adult patients with postlingual hearing loss who are scheduled to undergo CI.

Design:
Twenty-two adult patients with cochlear implants for postlingual hearing loss were evaluated using Doppler sonography measurement of the cervical arteries (reflecting cerebral blood flow), flow-mediated dilation (FMD; reflecting the condition of cerebral arteries), and their pre-/post-CI best score on a monosyllabic discrimination test (pre-/post-CI best monosyllabic discrimination [BMD] score). Correlations between post-CI BMD score and the other factors were examined using univariate analysis and stepwise multiple linear regression analysis. The prediction factors were calculated by examining the receiver-operating characteristic curve between post-CI BMD score and the significantly positively correlated factors.

Results:
Age and duration of deafness had a moderately negative correlation. The mean velocity of the internal carotid arteries and FMD had a moderate-to-strong positive correlation with the post-CI BMD score in univariate analysis. Stepwise multiple linear regression analysis revealed that only FMD was significantly positively correlated with post-CI BMD score. Analysis of the receiver-operating characteristic curve showed that a FMD cutoff score of 1.8 significantly predicted post-CI BMD score.

Conclusions:
These data suggest that FMD is a convenient, noninvasive, and widely available tool for predicting the efficacy of cochlear implants. An FMD cutoff score of 1.8 could be a good index for determining whether patients will hear well with cochlear implants. It could also be used to predict whether cochlear implants will provide good speech recognition benefits to candidates, even if their speech discrimination is poor. This FMD index could become a useful predictive tool for candidates with poor speech discrimination to determine the efficacy of CI before surgery.