bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KUALITAS PELAYANAN CUSTOMER SERVICE TERHADAP LOYALITAS PELANGGAN PADA TOKO NIBRAS HOUSE BEKASI
Authors: Novia Reni , Munjiarti Mumun 
Published: September 2024

This study aims to determine the effect of customer service quality on customer loyalty. The data collection method used is a questionnaire. The population in this study is customers of Toko Nibras House Bekasi who have customer membership status (membership) and have made product purchases in 2022. The sampling technique used was purposive sampling with a sample of 64 respondents. The data analysis methods used are validity tests, reliability tests, normality tests, linearity tests, simple linear regression analysis, and partial significance tests (T) using the SPSS 26 application. The results of this study showed that t-count > t-table (8.510 > 1.669). From the results of the t test, a significance value is also obtained smaller than 5% or 0.05 (0.000 < 0.05) so that it can be concluded that the quality of customer service has a positive and significant effect on customer loyalty at Nibras House Bekasi Store.

Keywords : Service Quality, Customer Service, Customer Loyalty, Customer Perception, Customer Expectations
PENGARUH MEDIA SOSIAL TERHADAP PRODUKTIFITAS GEN Z
Authors: Nurohmat Nurohmat , Latief Rusman , Safrudiningsih Safrudiningsih 
Published: September 2024

Pengaruh media sosial terhadap produktivitas mahasiswa telah menjadi topik yang menarik dan memprihatinkan. Artikel ini bertujuan untuk mengetahui dampak penggunaan media sosial terhadap produktivitas gen Z, dengan fokus pada kebiasaan penggunaan, pola interaksi, dan persepsi subjektif terhadap produktivitas. Memahami hubungan ini sangat penting mengingat peran media sosial yang luas dalam kehidupan individu Gen Z. Tinjauan literatur menyoroti kompleksitas hubungan ini, membahas bagaimana penggunaan media sosial yang berlebihan dapat mengganggu konsentrasi, manajemen waktu, dan kesejahteraan psikologis, sehingga berpotensi berdampak negatif pada produktivitas. Namun, strategi pengelolaan yang efektif, seperti alat manajemen waktu dan pembatasan akses, menawarkan jalan untuk memitigasi dampak negatif ini. Artikel ini diakhiri dengan diskusi mengenai implikasi temuan dan perlunya penelitian lebih lanjut untuk mengembangkan strategi dalam mempromosikan penggunaan media sosial yang sehat dan produktivitas di kalangan Generasi Z. Dalam penelitian ini, penulis mengambil sampel mahasiswa dan kaum pekerja muda di wilayah Barat. Jakarta. Dari penelitian ini, terlihat bahwa media sosial mendukung mereka dalam meningkatkan produktivitas.
Kata Kunci: Media Sosial, Siswa, Produktivitas, Kebiasaan Penggunaan, Pola Interaksi
Penguatan Kepemimpinan Visioner Dan Pengembangan Kepribadian Dalam Upaya Peningkatan Kreativitas Guru
Authors: Adawiah Siti Asiah , Suharyati Henny 
Published: September 2024

STRENGTHENING VISIONARY LEADERSHIP AND PERSONALITY DEVELOPMENT IN AN EFFORTS TO INCREASE TEACHER CREATIVITYTeachers are one of the components of education that aims to achieve the ten profiles of Indonesian humans by the law. However, teachers' creativity in permanent private high school foundation teachers an Accredited ”A” in Bekasi regency is still not optimal. Therefore, this research analyzes the relationship between visionary leadership personality development and teacher creativity. The method used in this research is a survey method with a correlation approach. This research was conducted at 18 private Islamic high schools accredited "A" in the Bekasi Regency area. The instrument used was a questionnaire in the form of a questionnaire indicated to 176 permanent foundation teachers. The analysis technique used simple correlation and multiple correlation. The study's results stated the following conclusions: (1) There was a positive relationship between visioner leadership and teacher creativity with a correlation coefficient ry.1=0.416 and a functional relationship equation Ŷ= 78.781+0.412X1. Visionary leadership contributes 36.49% of teacher creativity. This means that visionary leadership contributes to teacher creativity. (2) There was a positive relationship between personality and teacher creativity with a correlation coefficient ry.2=0.437 and a functional relationship equation Ŷ = 84,864 + 0,351 X2. Visionary leadership contributes 36.49% of teacher creativity. This means that personality contributes to teacher creativity. (3) There was a positive relationship between visionary leadership and personality and teacher creativity with a correlation coefficient R= 0.510 and a functional relationship equation Ŷ = 59.684 + 0.285 X1 + 0.259 X2. The contribution of visionary leadership and personality and teacher creativity implied that the teacher's creativity would be progressively better than visionary leadership and personality. The contribution of visionary leadership and personality to teacher creativity was 26,1%. Thus it can be concluded that teacher creativity can be increased through visionary leadership and individual personality.
REDUPLIKASI VERBA BAHASA MUNA DIALEK KIOKO
Authors: Mustopa Ali , Abroor Awalul 
Published: September 2024

Penelitian ini bertujuan mendeskripsikan reduplikasi verba bahasa Muna dialek Kioko. Penelitian ini menggunakan metode deskriptif kualitatif. Data yang dikumpulkan kemudian dianalisis melalui teknik top down (analisis menurun) untuk menganalisis bentuk reduplikasi verba bahasa Muna dialek Kioko, teknik semantis untuk menganalisis makna reduplikasi verba bahasa Muna dialek Kioko, dan teknik unsur pilar langsung untuk menganalisis fungsi reduplikasi verba bahasa Muna dialek Kioko. Reduplikasi verba bahasa Muna dialek Kioko dapat ditemukan tiga jenis reduplikasi yaitu reduplikasi utuh, reduplikasi sebagian yaitu terjadinya pengulangan didua atau tiga suku kata pertama dan reduplikasi berafiks. Makna reduplikasi verba bahasa Muna dialek Kioko yaitu, (1) penuturan makna ‘banyak’, (2) tuturan makna ‘suruhan atau permintaan’, (3) tuturan makna ‘perbuatan tersebut ialah pada bentuk dasar yang berulang-ulang’, (4) tuturan makna ‘perbuatan ialah bentuk dasar yang dilakukan dengan santainya’, (5) tuturan mengenai perbuatan tersebut ialah dilakukan oleh dua belah pihak dan saling mengenai’, (6) tuturan makna yang menyatakan intensitas perasaan yang sebenarnya makna dari bentuk dasar. Fungsi reduplikasi ada dua yaitu fungsi gramatikal dan fungsi semantis. Fungsi reduplikasi verba bahasa Muna dialek Kioko ada yang bersifat derivasional (yang mengubah kelas kata) dan ada pula yang tidak merubah kelas kata ketika afiks berdistribusi dengan bentuk dasar sehingga membentuk kata ulang. Reduplikasi berafiks dalam reduplikasi verba bahasa Muna dialek Kioko yaitu prefiks (nee-, me-, ae-, po-, dan poka-), infiks (-um), sufiks (-ci, -e, -ane, dan –anda), konfiks (po-+-li dan po-+-ane), kombinasi afiks/infiks-sufiks (-um –no).
Kata Kunci: Reduplikasi, bahasa Muna, dialek Kioko
First-trimester predictive models for adverse pregnancy outcomes—a base for implementation of strategies to prevent cardiovascular disease development
Authors: Hromadnikova Ilona , Kotlabova Katerina , Krofta Ladislav 
Published: September 2024

IntroductionThis study aimed to establish efficient, cost-effective, and early predictive models for adverse pregnancy outcomes based on the combinations of a minimum number of miRNA biomarkers, whose altered expression was observed in specific pregnancy-related complications and selected maternal clinical characteristics.MethodsThis retrospective study included singleton pregnancies with gestational hypertension (GH, n = 83), preeclampsia (PE, n = 66), HELLP syndrome (n = 14), fetal growth restriction (FGR, n = 82), small for gestational age (SGA, n = 37), gestational diabetes mellitus (GDM, n = 121), preterm birth in the absence of other complications (n = 106), late miscarriage (n = 34), stillbirth (n = 24), and 80 normal term pregnancies. MiRNA gene expression profiling was performed on the whole peripheral venous blood samples collected between 10 and 13 weeks of gestation using real-time reverse transcription polymerase chain reaction (RT-PCR).ResultsMost pregnancies with adverse outcomes were identified using the proposed approach (the combinations of selected miRNAs and appropriate maternal clinical characteristics) (GH, 69.88%; PE, 83.33%; HELLP, 92.86%; FGR, 73.17%; SGA, 81.08%; GDM on therapy, 89.47%; and late miscarriage, 84.85%). In the case of stillbirth, no addition of maternal clinical characteristics to the predictive model was necessary because a high detection rate was achieved by a combination of miRNA biomarkers only [91.67% cases at 10.0% false positive rate (FPR)].ConclusionThe proposed models based on the combinations of selected cardiovascular disease-associated miRNAs and maternal clinical variables have a high predictive potential for identifying women at increased risk of adverse pregnancy outcomes; this can be incorporated into routine first-trimester screening programs. Preventive programs can be initiated based on these models to lower cardiovascular risk and prevent the development of metabolic/cardiovascular/cerebrovascular diseases because timely implementation of beneficial lifestyle strategies may reverse the dysregulation of miRNAs maintaining and controlling the cardiovascular system.
Risk factors for cardiometabolic health in Ghana: Cardiometabolic Risks Study Protocol-APTI Project
Authors: Hormenu Thomas , Salifu Iddrisu , Antiri Ebenezer Oduro , Paku Juliet Elikem , Arthur Aaron Rudolf , Nyane Benjamin , Ableh Eric Awlime , Gablah Augustine Mac-Hubert , Banson Cecil , Amoah Samuel , Ishimwe Marie Consolatrice Sage , Mugeni Regine 
Published: September 2024

IntroductionCardiometabolic diseases are rapidly becoming primary causes of death in developing countries, including Ghana. However, risk factors for these diseases, including obesity phenotype, and availability of cost-effective diagnostic criteria are poorly documented in an African-ancestry populations in their native locations. The extent to which the environment, occupation, geography, stress, and sleep habits contribute to the development of Cardiometabolic disorders should be examined.PurposeThe overall goal of this study is to determine the prevalence of undiagnosed diabetes, prediabetes, and associated cardiovascular risks using a multi-sampled oral glucose tolerance test. The study will also investigate the phenotype and ocular characteristics of diabetes and prediabetes subgroups, as well as determine if lifestyle changes over a one-year period will impact the progression of diabetes and prediabetes.Methods and analysisThe study employs a community-based quasi-experimental design, making use of pre- and post-intervention data, as well as a questionnaire survey of 1200 individuals residing in the Cape Coast metropolis to ascertain the prevalence and risk factors for undiagnosed diabetes and prediabetes. Physical activity, dietary habits, stress levels, sleep patterns, body image perception, and demographic characteristics will be assessed. Glucose dysregulation will be detected using oral glucose tolerance test, fasting plasma glucose, and glycated hemoglobin. Liver and kidney function will also be assessed. Diabetes and prediabetes will be classified using the American Diabetes Association criteria. Descriptive statistics, including percentages, will be used to determine the prevalence of undiagnosed diabetes and cardiovascular risks. Inferential statistics, including ANOVA, t-tests, chi-square tests, ROC curves, logistic regression, and linear mixed model regression will be used to analyze the phenotypic variations in the population, ocular characteristics, glycemic levels, sensitivity levels of diagnostic tests, etiological cause of diabetes in the population, and effects of lifestyle modifications, respectively. Additionally, t-tests will be used to assess changes in glucose regulation biomarkers after lifestyle modifications.Ethics and disseminationEthics approval was granted by the Institutional Review Board of the University of Cape Coast, Ghana (UCCIRB/EXT/2022/27). The findings will be disseminated in community workshops, online learning platforms, academic conferences and submitted to peer-reviewed journals for publication.
Case report: A novel TLK2 variant with a neuropsychiatric phenotype from a Chinese family
Authors: Huang Hongmei , Qian Yue , Yang Chenlu , Li Shijie 
Published: September 2024

BackgroundTousled-like kinase 2 (TLK2) gene variant-related neurodevelopmental disorder was recently described. The haploinsufficiency of TLK2 was considered the most likely underlying disease mechanism, leading to a consistent neurodevelopmental phenotype. So far, only four studies, conducted on 49 patients from North America and Europe, have been reported.Case presentationIn this study, we reported a Chinese family with a TLK2-related neuropsychiatric phenotype. The proband, a boy aged 2 years and 6 months, presented with temper tantrums, mood lability, aggressiveness, congenital astigmatism, and distinctive facial dysmorphism. Whole-exome sequencing identified a novel heterozygous variation in TLK2 gene (c.49dupG, p. E17Gfs*10) in them. His father carried the same TLK2 gene variant and exhibited anxiety and irritability. The parental grandparents and other family members had no such variation. Moreover, the proband was found to have global developmental delay, autism-like symptoms, and mild elevated homo-vanillic acid (HVA) and 2,3-dihydroxy-2-methylbutyric acid levels tested in urine.ConclusionHerein, we identified a novel TLK2 variant from a Chinese family and reported a new neuropsychiatric phenotype. This study also expanded the genotype profile of the newly defined TLK2-related neurodevelopmental disorder.
Risk factors for regional lymph node metastasis in rectal neuroendocrine tumors: a population-based study
Authors: Li Ruizhen , Li Xiaofen , Wang Yan , Chang Chen , Lv Wanrui , Li Xiaoying , Cao Dan 
Published: September 2024

IntroductionThe identification of risk factors for regional lymph node (r-LN) metastasis in rectal neuroendocrine tumors (R-NETs) remains challenging. Our objective was to investigate the risk factors associated with patients diagnosed with R-NETs exhibiting r-LN metastasis.MethodsPatient information was obtained from the Surveillance, Epidemiology, and End Results (SEER) database, complemented by data from the West China Hospital (WCH) databases. The construction cohort comprised patients diagnosed with R-NETs from the SEER database, while cases from the WCH database were utilized as the validation cohort. A novel nomogram was developed to predict the probability of r-LN metastasis, employing a logistic regression model.ResultsUnivariate analysis identified four independent risk factors associated with poor r-LN metastasis: age (HR = 1.027, p &lt; 0.05), grade (HR = 0.010, p &lt; 0.05), T stage (HR = 0.010, p &lt; 0.05), and tumor size (HR = 0.005, p &lt; 0.05). These factors were selected as predictors for nomogram construction.DiscussionThe novel nomogram serves as a reliable tool for predicting the risk of r-LN metastasis, providing clinicians with valuable assistance in identifying high-risk patients and tailoring individualized treatments.
The impact of pulmonary tuberculosis on SARS-CoV-2 infection: a nationwide cohort study
Authors: Lee Sang Hwan , Kim Yun Jin , Oh Jaehoon , Kang Hyunggoo , Yoo Kyung Hun , Ko Byuk Sung , Lim Tae Ho , Kim Bo-Guen , Lee Hyun , Kim Sang-Heon , Sohn Jang Won , Yoon Ho Joo , Choi Hayoung , Cho Yongil , Park Dong Won 
Published: September 2024

BackgroundThe interaction between COVID-19 and tuberculosis (TB) is not yet fully understood, and large-scale research on the mortality outcome of such dual infection has been limited. This study aimed to investigate the impact of PTB on mortality among patients with COVID-19 within a Korean population by conducting an extensive analysis of a nationwide large dataset.MethodWe investigated the mortality and disease severity among COVID-19 patients who had PTB in South Korea. This study analyzed 462,444 out of 566,494 COVID-19 patients identified between January 2020 and December 2021.ResultA total of 203 COVID-19 with PTB patients and 812 matched COVID-19 without PTB were analyzed using 1:4 propensity score matching. COVID-19 patients with PTB exhibited higher in-hospital mortality (odds ratio (OR) 3.02, 95% confidence interval (CI) 1.45–6.27, p-value = 0.003) and were at increased risk of requiring conventional oxygen therapy (OR 1.57, 95% CI 1.10–2.25, p-value = 0.013) as well as high flow nasal cannula (HFNC) or noninvasive ventilation (NIV) oxygen therapy (OR 1.91, 95 CI 1.10–3.32, p-value = 0.022) compared to those without PTB. Compared to matched COVID-19 without PTB, co-infected patients showed increased mortality rates across various timeframes, including during hospitalization, and at 30 day and 90 day intervals. In-hospital mortality rates were particularly elevated among women, individuals with malignancy, and those with lower incomes. Furthermore, the increased in-hospital mortality among PTB patients persisted irrespective of the timing of TB diagnosis or vaccination status against COVID-19.ConclusionWe suggest that physicians be aware of the risk of mortality and severity among COVID-19 patients with PTB; coinfection with COVID-19 is a critical situation that remains to be further explored and needs more attention in countries with an intermediate to high PTB burden.
Correlation between ratio of fasting blood glucose to high density lipoprotein cholesterol in serum and non-alcoholic fatty liver disease in American adults: a population based analysis
Authors: Jin Xianjing , Xu Jing , Weng Xiaochun 
Published: September 2024

BackgroundBased on previous research, elevated fasting blood glucose (FBG) and decreased high-density lipoprotein cholesterol (HDL-C) levels are associated with non-alcoholic fatty liver disease (NAFLD). It is hypothesized that the prevalence of NAFLD may be proportional to the FBG-to-HDL-C ratio (GHR).MethodsIn this study, 3,842 participants from the National Health and Nutrition Examination Survey (NHANES) (2013–2020) were investigated. Liver steatosis was assessed using vibration-controlled transient elastography (VCTE). NAFLD was defined as controlled attenuation parameter (CAP) ≥288 dB/m.ResultsAfter adjusting for race, gender, age, diabetes, BMI, moderate activities, uric acid, albumin, ALT, GGT, ALP, total bilirubin and creatinine, multiple logistic regression analysis indicated a positive correlation between GHR and the prevalence of NAFLD (OR = 1.22, 95% CI = 1.17–1.28). Additionally, multiple linear regression analysis showed a positive correlation between GHR and the severity of liver steatosis according to CA p-values (β = 4.97, 95% CI: 4.28, 5.66). According to the subgroup analysis, the correlation was stronger in other race, participants at the age &lt;50 years old and those with non-diabetes. In this study, a non-linear relationship and saturation effect between GHR and the prevalence of NAFLD was also revealed, characterized by an inverted L-shaped curve, with an inflection point of 7.443. Finally, the receiver operating characteristic (ROC) analysis suggested that the area under the curve (AUC) of GHR (AUC = 0.731) significantly exceeded that of FBG and HDL-C.ConclusionElevated GHR levels are independently associated with the severity of liver steatosis and the increased prevalence of NAFLD in American adults.
A combination analysis based on bioinformatics tools reveals new signature genes related to maternal obesity and fetal programming
Authors: Liu Chunhong , Lu Yulan , Huang Chunchuan , Zeng Yonglong , Zheng Yuye , Wang Chunfang , Huang Huatuo 
Published: September 2024

BackgroundMaternal obesity significantly influences fetal development and health later in life; however, the molecular mechanisms behind it remain unclear. This study aims to investigate signature genes related to maternal obesity and fetal programming based on a genomic-wide transcriptional placental study using a combination of different bioinformatics tools.MethodsThe dataset (GSE128381) was obtained from Gene Expression Omnibus (GEO). The data of 100 normal body mass index (BMI) and 27 obese mothers were included in the analysis. Differentially expressed genes (DEGs) were evaluated by limma package. Thereafter, functional enrichment analysis was implemented. Then, weighted gene co-expression network analysis (WGCNA) and the least absolute shrinkage and selection operator (LASSO) analysis were used to further screening of signature genes. Simple linear regression analysis was used to assess the correlation between signature genes and newborn birth weight. Gene set enrichment analysis (GSEA) was implemented to study signaling pathways related to signature genes. The expression of the signature genes was also explored in 48 overweight mothers in the same dataset.ResultsA total of 167 DEGs were obtained, of which 122 were up-regulated while 45 were down-regulated. The dataset was then clustered into 11 modules by WGCNA, and the MEbrown was found as the most significant module related to maternal obesity and fetal programming (cor = 0.2, p = 0.03). The LASSO analysis showed that PTX3, NCF2, HOXB5, ABCA6, and C1orf162 are signature genes related to maternal obesity and fetal programming, which were increased in the placenta of obese mothers compared to those with normal BMI. The area under the curve (AUC) of the signature genes in the receiver operating characteristic curve (ROC) was 0.709, 0.660, 0.674, 0.667, and 0.717, respectively. Simple linear regression analysis showed that HOXB5 was associated with newborn birth weight. GSEA analysis revealed that these signature genes positively participate in various signaling pathways/functions in the placenta.ConclusionPTX3, NCF2, HOXB5, ABCA6, and C1orf162 are novel signature genes related to maternal obesity and fetal programming, of which HOXB5 is implicated in newborn birth weight.