bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Minimally Invasive Technique to Reduce Platysma Banding
Authors: Herron Joel Bain , Khan Azim J. , Bisaccia Emil , Scarborough Dwight A. 
Published: July 2017

Introduction: Senescent changes of the submandibular zone and neck contribute to an obtuse cervicomental angle, submental fullness, and platysma band formation. Many open techniques for repair of platysma bands have been described previously. Minimally invasive techniques early in the aging process are desirable interventions for rejuvenation with minimal risks and recovery. We describe a minimally invasive approach to correct platysma bands with a suture support sling in the submandibular sulcus. Materials and Methods: By modifying the typical liposuction of the neck and jowls to include superficial tunneling along the submandibular sulcus with a small cannula, an expanded polytetrafluoroethylene (E-PTFE, trade name Gore-Tex) suture may be placed traversing from mastoid fascia to mastoid fascia. Results: Compression of the platysma bands is achieved with restoration of the cervicomental angle and a more youthful-appearing profile. Recovery is rapid with untoward effects minimized. Discussion: The described suture support sling is a minimally invasive option to the choices when approaching correction of platysma bands.
Autologous Fat Augmentation and Periorbital Laser Resurfacing Complicated by Abscess Formation
Authors: Obagi Suzan 
Published: July 2017

Introduction: There are many modalities for rejuvenation of the aging face, including rhytidectomy, soft tissue augmentation, and skin resurfacing. Skin resurfacing modalities for the treatment of rhytides include chemical peels, dermabrasion, and laser resurfacing. Complications of skin resurfacing include infection, prolonged erythema, and scar formation. Autologous fat augmentation used for soft tissue “rejuvenation” of the face has the advantages of having no allergic reactions or rejection. Complications include edema, ecchymoses, pain, nerve or blood vessel damage, infections, and rarely orbital or cerebral emboli. The author presents a case of an abscess formation of the lacrimal duct system in a patient with autologous fat augmentation and laser resurfacing preceded by tear-duct punctal plugs 1 week prior to surgery. Materials and Methods: An overall healthy 55-year-old female was seeking treatment of periorbital rhytides and mild dermatochalasis, prominent nasojugal creases, malar fat pad ptosis, prominent melolabial folds, and mild jowling. She underwent periorbital laser resurfacing, autologous fat augmentation (malar eminence, infraorbital region, melolabial folds), and liposuction of the jowls. One week prior to her surgery the patient had punctal tear duct plugs placed for the treatment of epiphora. Results: The patient developed unilateral facial pain and edema with subsequent abscess formation along the right infraorbital region. A CT-scan was obtained which showed soft tissue swelling without the presence of a retro-orbital cellulitis. The abscess was drained and antibiotic treatment administered. A diagnosis of dacryocystitis was made and upon dacryocystorhinostomy, a large dacryolith was discovered. Discussion: Although surgeons are aware of the complications associated with the procedures they perform, it is extremely important to keep in mind other surgeries that patients may have had elsewhere and the complications associated with them.
Documentation of Clinical Pharmacy Activities in a VA Hospital
Authors: Bergman H. D. , Fletcher H. P. , Sperandio G. J. 
Published: July 2017

A nine-month study conducted on a general medical ward of the Veterans Administration Hospital in Danville, Illinois, was designed to investigate several aspects of the pharmacist's clinical roles. The pharmacist detected and evaluated suspected adverse drug reactions (SADR) and deviations from medication administration procedures (DMAP) and maintained a log of all questions and contributions to the patient's therapy. A SADR was defined as any unintended or undesired effect of a drug. A DMAP was defined as a change from the physician's order as written on the chart. The pharmacist collected demographic data and maintained medication records on all patients. If a SADR or DMAP was detected by the pharmacist, he evaluated the event and completed the appropriate records describing the event. Eighty-six SADR were detected in 60 (35.5 percent) of the 169 hospitalized patients in the 9-month study. Discontinuation of the drug, additional treatment or hospitalization, and/or a change in the administration of the drug was required in 66 (76.7 percent of the 86 SADR. Patients experiencing SADR received a higher average number of drugs and had a longer average duration of hospitalization than the patients without SADR. Ten DMAP were detected in 4504 doses in the 6-month study, resulting in a 0.2 percent deviation rate. The wrong dose was the type of DMAP in 50 percent of the cases. There were 276 questions and contributions to patient care encountered by the pharmacist in the 5-month study. The majority were classified as therapeutic. In conclusion, the clinical pharmacist can and should be utilized in both research and service functions in the clinical setting.
Cumulative Effects of Concussion History on Baseline Computerized Neurocognitive Test Scores: Systematic Review and Meta-analysis
Authors: Alsalaheen Bara , Stockdale Kayla , Pechumer Dana , Giessing Alexander , He Xuming , Broglio Steven P. 
Published: July 2017

Context: It is unclear whether individuals with a history of single or multiple clinically recovered concussions exhibit worse cognitive performance on baseline testing compared with individuals with no concussion history. Objective: To analyze the effects of concussion history on baseline neurocognitive performance using a computerized neurocognitive test. Data sources: PubMed, CINAHL, and psycINFO were searched in November 2015. The search was supplemented by a hand search of references. Study Selection: Studies were included if participants completed the Immediate Post-concussion Assessment and Cognitive Test (ImPACT) at baseline (ie, preseason) and if performance was stratified by previous history of single or multiple concussions. Study Design: Systematic review and meta-analysis. Level of Evidence: Level 2. Data Extraction: Sample size, demographic characteristics of participants, as well as performance of participants on verbal memory, visual memory, visual-motor processing speed, and reaction time were extracted from each study. Results: A random-effects pooled meta-analysis revealed that, with the exception of worsened visual memory for those with 1 previous concussion (Hedges g = 0.10), no differences were observed between participants with 1 or multiple concussions compared with participants without previous concussions. Conclusion: With the exception of decreased visual memory based on history of 1 concussion, history of 1 or multiple concussions was not associated with worse baseline cognitive performance.
Structural basis of divergent cyclin‐dependent kinase activation by Spy1/RINGO proteins
Authors: McGrath Denise A , Fifield Bre‐Anne , Marceau Aimee H , Tripathi Sarvind , Porter Lisa A , Rubin Seth M 
Published: July 2017

AbstractCyclin‐dependent kinases (Cdks) are principal drivers of cell division and are an important therapeutic target to inhibit aberrant proliferation. Cdk enzymatic activity is tightly controlled through cyclin interactions, posttranslational modifications, and binding of inhibitors such as the p27 tumor suppressor protein. Spy1/RINGO (Spy1) proteins bind and activate Cdk but are resistant to canonical regulatory mechanisms that establish cell‐cycle checkpoints. Cancer cells exploit Spy1 to stimulate proliferation through inappropriate activation of Cdks, yet the mechanism is unknown. We have determined crystal structures of the Cdk2‐Spy1 and p27‐Cdk2‐Spy1 complexes that reveal how Spy1 activates Cdk. We find that Spy1 confers structural changes to Cdk2 that obviate the requirement of Cdk activation loop phosphorylation. Spy1 lacks the cyclin‐binding site that mediates p27 and substrate affinity, explaining why Cdk‐Spy1 is poorly inhibited by p27 and lacks specificity for substrates with cyclin‐docking sites. We identify mutations in Spy1 that ablate its ability to activate Cdk2 and to proliferate cells. Our structural description of Spy1 provides important mechanistic insights that may be utilized for targeting upregulated Spy1 in cancer.
An RNA Recognition Motif-Containing Protein Functions in Meiotic Silencing by Unpaired DNA
Authors: Samarajeewa Dilini A , Manitchotpisit Pennapa , Henderson Miranda , Xiao Hua , Rehard David G , Edwards Kevin A , Shiu Patrick K T , Hammond Thomas M 
Published: July 2017

AbstractMeiotic silencing by unpaired DNA (MSUD) is a biological process that searches pairs of homologous chromosomes (homologs) for segments of DNA that are unpaired. Genes found within unpaired segments are silenced for the duration of meiosis. In this report, we describe the identification and characterization of Neurospora crassa sad-7, a gene that encodes a protein with an RNA recognition motif (RRM). Orthologs of sad-7 are found in a wide range of ascomycete fungi. In N. crassa, sad-7 is required for a fully efficient MSUD response to unpaired genes. Additionally, at least one parent must have a functional sad-7 allele for a cross to produce ascospores. Although sad-7-null crosses are barren, sad-7Δ strains grow at a wild-type (wt) rate and appear normal under vegetative growth conditions. With respect to expression, sad-7 is transcribed at baseline levels in early vegetative cultures, at slightly higher levels in mating-competent cultures, and is at its highest level during mating. These findings suggest that SAD-7 is specific to mating-competent and sexual cultures. Although the role of SAD-7 in MSUD remains elusive, green fluorescent protein (GFP)-based tagging studies place SAD-7 within nuclei, perinuclear regions, and cytoplasmic foci of meiotic cells. This localization pattern is unique among known MSUD proteins and raises the possibility that SAD-7 coordinates nuclear, perinuclear, and cytoplasmic aspects of MSUD.
Az adriai sallangvirág (Himantoglossum adriaticum) magyarországi állományai és lelőhelyeik tájhasználatának története
Authors: Bódis Judit 
Published: July 2017

Az adriai sallangvirág (Himantoglossum adriaticum H. Baumann) Magyarországon foko­zottan védett, közösségi jelentőségű növényfaj. Hazai állományait 1992 óta vizsgálva, a területek egyes sajátosságainak hasonlóságait észleve, fordult érdeklődésem a lelőhelyek tájhasználat története irá­nyába. Az általam legrégebb óta nyomon követett populáció a Keszthelyi-hegységben található, ahol 1992 és 2016 között 7 és 78 között változott a virágzó egyedek száma. Újabban két kisebb állománya is előkerült a fajnak a hegységből. Az állományok egykori legelő szegélyében, földút mentén, illetve szőlők közelében vannak. A legnagyobb populáció a Sümeg–Tapolcai-háton található, nagyobbrészt a közút szélén. A megfigyelt években mintegy 1000–2000 egyedből a virágzó példányok száma 10 (2012) és 214 (2014) között váltakozott. Kőszegen, a város szőlőhegyén magánkertekben, extenzíven kaszált parlagokon és gyümölcsösökben találhatóak, ahol összesen akár 165 (2016) virágzó tő is lehet. A Ba­konyban kb. 50 éve felhagyott szőlők és gyümölcsösök helyén találhatók, az állomány nagysága kb. a Keszthelyi-hegységivel azonos. A hazai öt állományból négy helyen van, ahol (vagy a közelében) már az I. Katonai Felmérés idején (1783–84) szőlő- vagy gyümölcsöskert volt. Ez alól csak a Sümeg–Tapolcai-háton lévő populáció kivétel. A sallangvirágok számára a legjelentősebb veszélyeztető tényező a be­cserjésedés, de a faj képes új helyeken megjelenni, bízhatunk állományainak fennmaradásában.
Transformational Leadership Potential At A University Of Technology
Authors: Herbst Tessie H. H. , Garg Ajay K. 
Published: July 2017

In South Africa as elsewhere in the world, higher education institutions have been criticised for a lack of transformation. This apparent lack of transformation called into question the capability of the leaders within these institutions to effectively lead change and transform the higher education institutional landscape. The aim of this study was to explore the transformational leadership competency potential amongst managers in a university of technology in South Africa. The measures of potential used are eight competency factors known as the ‘Great Eight’ (Bartram, 2005) derived from Occupational Personality Questionnaire (OPQ32) scale scores. The OPQ32r was administered to 111 managers within a university of technology. The majority of respondents had a balanced mix of styles between a transformational and transactional focus. These leaders not only exhibit less transformational competencies but also an insufficient strong transactional focus. These findings have severe implications for the transformation of
Doença Invasiva Pneumocócica Pediátrica Antes da Vacinação Universal: 1995 - 2015
Authors: Ferreira Muriel , Oliveira Henrique , Silva Nuno Costa e , Januário Luís , Rodrigues Fernanda 
Published: July 2017

Introdução: A vacina conjugada pneumocócica foi introduzida no mercado privado português em 2001, atingindo ao longo dos anos coberturas moderadamente elevadas. Em julho de 2015 foi integrada no Programa Nacional de Vacinação. O objetivo deste estudo foi caracterizar a doença invasiva pneumocócica num hospital pediátrico antes da vacinação universal.Material e Métodos: Análise retrospetiva dos processos clínicos de todas as crianças com identificação de Streptococcus pneumoniae por cultura e/ou por biologia molecular (disponível desde 2008), em produtos obtidos de locais estéreis, de janeiro 1995 a junho 2015, avaliando dados demográficos, clínicos e microbiológicos. Os serotipos estão disponíveis desde 2004.Resultados: Ao longo destes 20 anos identificámos 112 casos de doença invasiva pneumocócica, com idade mediana de 15 meses (1 mês - 15 anos). A mediana de casos/ano foi 4, com valores máximos entre 2001 - 2002 (8/ano) e 2007 - 2012 (7 - 11/ano). A identificação ocorreu maioritariamente em hemocultura (72), líquido cefalorraquidiano (24), líquido pleural (11) e outros (5). Os diagnósticos mais frequentes foram pneumonia (38%), bacteriemia oculta (34%) e meningite (21%). Ao longo do período em análise, observou-se um aumento do diagnóstico de pneumonia e aumento ligeiro de bacteriemia oculta, tendo-se mantido relativamente constante o de meningite.Discussão: Nas últimas duas décadas não se observou redução do número de casos de doença invasiva pneumocócica, tendo ocorrido um aumento da identificação de pneumococo em pneumonia e bacteriemia oculta, para o qual poderão ter contribuído a introdução dos métodos de biologia molecular e a realização de mais hemoculturas. Os serotipos vacinais foram predominantes.Conclusão: Esta analise retrospetiva pré vacinação universal, contribuirá para avaliar o impacto da vacinação na população pediátrica portuguesa.
Investigação de Etiologia Genética nas Ataxias Neurodegenerativas: Recomendações do Grupo de Neurogenética do Centro Hospitalar São João, Portugal
Authors: Gomes Tiago , Guimaraes Joana , Leão Miguel , Grupo de Neurogenética do Centro Hospitalar São João Em nome do 
Published: July 2017

Nas últimas décadas foi identificada uma lista crescente de ataxias neurodegenerativas de causa monogénica, permitindo uma melhor caracterização da patofisiologia, fenótipo e prognóstico deste grupo heterogéneos de patologias e revelando potenciais novos alvos terapêuticos. No entanto, a heterogeneidade e complexidade da relação genótipo-fenótipo e os elevados custos inerentes às técnicas de genética molecular, dificultam o plano racional clínico na orientação da investigação destas doenças. A história clínica é essencial à orientação diagnóstica, mas frequentemente o fenótipo não detém especificidade suficiente para permitir prever o genótipo. O Grupo de Neurogenética do Centro Hospitalar São João, grupo multidisciplinar de neurologistas e geneticistas com interesse especial na área das doenças neurogenéticas, delineou recomendações de consenso para a investigação da etiologia genética das ataxias neurodegenerativas, tendo por base documentos de consenso internacionais (contendo atualmente informação potencialmente desatualizada) e a evidência científica publicada sobre este tópico. Atualmente estão bem descritos aproximadamente 10 loci autossómicos recessivos e mais de 27 loci autossómicos dominantes para as ataxias neurodegenerativas. Este documento aborda de forma pragmática o processo utilizado para o diagnóstico genético das ataxias neurodegenerativas, com recomendações específicas para os diversos grupos de ataxias hereditárias e adaptado à realidade Portuguesa.
SYNTHESIS AND CHARACTERIZATION OF INDINAVIR-Cu COMPLEX
Authors: T Rajkumar , L Sivasanker Reddy , L Sivasanker Reddy , V Rajeswari , V Rajeswari 
Published: July 2017

Objective: The main objective of the present work is to synthesize Cu (II) indinavir, complex.Methods: The indinavir complexes were discussed with the help of spectroscopic instrumental methods such as infrared, ultraviolet, nuclear magnetic resonance, and mass and titrimetry methods (iodometry and potentiometry). Drug and drug metal complex are screened against antimicrobial activity.Results: The spectral studies show that the metal is coordinated to the drug in a bidentate manner. The titrimetry method, i.e., iodometric titration shows that metal bind to the drug in proportion of 1:1. The potentiometric titration curves of indinavir-Cu metal complex are mostly same which proves that the metal which might be present in the complex do not affect the titration curves. The result shows that the drug metal complex has enhanced inhibitory activity than drug under identical conditions in concentration ranges of 12.5 μg/ml in Staph and Bacillus species whereas in disc diffusion procedure zone of inhibition is 13 mm and 18 mm in Staph and Bacillus species.Conclusion: Indinavir-Cu complex had been synthesized and characterized by spectral techniques which shows enhanced microbial activity than drug.
Spectroscopic Investigation for Photo stability of Hydrochlorothiazide Complexes with β-Cyclodextrin and HPMC.
Authors: Dhekale Pallavi Shrirang 
Published: July 2017

Hydrochlorothiazide (HCT) is a poorly water-soluble drug. The aim of this study was to determine whether inclusion complexes between β-cyclodextrin and HCT are formed and also studied effect of auxiliary substance (HPMC) on HCT, photo-stability of HCT and to characterize these. Equimolar HCT/ βCD solid systems in the presence or absence of 0.2% (w/v) of HPMC were prepared by kneading method. The systems were characterized by phase solubility, Dissolution study, FTIR, DSC and the photo-stability test followed by u.v. spectroscopy. The results suggest that true binary and ternary inclusion complex. The test results have proved that the complexed HCT with hydroxypropyl β- cyclodextrin enhance the photo degradation rate and resolute the optimal molar ratio HCT to hydroxypropyl β- cyclodextrin as 1:1.
A Knowledge-Based Demand Side Management: Interruptible Direct Load Approach
Authors: Apena Waliu Olalekan 
Published: July 2017

The study focussed on managing electrical energy supplied to consumers from distribution end through initial knowledge on data acquisition and embedded system. It was achieved by controlling the inductive loads at the consumer premise. The study re-shaped the load and energy demand curve by cycling customers’ inductive loads which are prone to drawing high currents such as air conditioner and water heaters. Data from power utilities were gathered and analysed using tools to generate waveform pattern for energy consumption. Mathematical models for air conditioners and water heaters were derived in order to remotely control the appliances with the aids of embedded system implemented on the consumer premise.
OPTIMIZED OPERATION OF AN INTEGRATED SOLAR DESALINATION AND AIR-CONDITIONING SYSTEM: THEORETICAL STUDY
Authors: K. Ghali  , N. Ghaddar  , A. Alsaidi  
Published: July 2017

Integrating the solar distiller with the air-conditioning system can increase the condensate output from the solar stiller while meeting the cooling load needs. The operation of the combined solar distillation and air conditioning system has been modeled and simulated to predict distillate output from the cooling coil for the combined system for a residential space application in the suburbs of Beirut. An optimization problem is formulated to optimize the integrated system operation for minimum energy consumption while meeting the hourly cooling load and the daily fresh water need of 100 liters. The design variable in the optimization study is the fresh air flow rate that passes through the distiller and mixes with return air for the constant volume space supply fan. The optimization problem is solved for a 10-hour of operation of the combined system for the summer months: June, August and October. It is found that the cost of fresh water production of the combined system is 0.108 kWh/ liter for the month of August and 0.12 kWh/liter of fresh water in October.
Cervical Myelopathy in a Patient Referred for Lower Extremity Symptoms
Authors: Jackson Steven M. 
Published: July 2017

The patient was a 38-year-old male referred to physical therapy with complaints of right lower extremity radicular pain and left lower extremity weakness. Following physical therapy examination, the primary care physician referred the patient to a neurologist, who performed electromyography and nerve conduction studies and ordered a magnetic resonance image. Cervical spine imaging revealed a C5–6 disc extrusion with myelopathy. J Orthop Sports Phys Ther 2017;47(7):510. doi:10.2519/jospt.2017.5071