bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conceptualizing Accessibility for English Language Proficiency Assessments
Authors: Guzman‐Orth Danielle , Laitusis Cara , Thurlow Martha , Christensen Laurene 
Published: April 2016

AbstractThis paper is the second in a series from Educational Testing Service (ETS) that conceptualizes next‐generation English language proficiency (ELP) assessment systems for K‐12 English learners (ELs) in the United States. The first paper articulated a high‐level conceptualization of next‐generation ELP assessment systems (Hauck, Wolf, & Mislevy, 2016), the third paper addressed issues related to summative ELP assessments that emerged from the presentations and discussions at the English Language Proficiency Assessment Research working meeting (Wolf, Guzman‐Orth, & Hauck, 2016), and the fourth paper focused on a key concern within such systems—the initial identification and classification of ELs (Lopez, Pooler, & Linquanti, 2016). The goal of this paper is to address accessibility issues in the context of ELP assessments and to discuss critical considerations to improve the accessibility of ELP assessments for ELs and ELs with disabilities. Although accessibility for ELs and ELs with disabilities who are taking content assessments is also important, a discussion about content assessments is beyond the scope of the paper at this time. In this paper, we discuss challenges and areas of possible directions to pursue for ongoing and future ELP assessment development, policy implications, and research considerations to improve the ELP testing experience for all users.
Fitted finite element discretization of two‐phase Stokes flow
Authors: Agnese Marco , Nürnberg Robert 
Published: April 2016

SummaryWe propose a novel fitted finite element method for two‐phase Stokes flow problems that uses piecewise linear finite elements to approximate the moving interface. The method can be shown to be unconditionally stable. Moreover, spherical stationary solutions are captured exactly by the numerical approximation. In addition, the meshes describing the discrete interface in general do not deteriorate in time, which means that in numerical simulations, a smoothing or a remeshing of the interface mesh is not necessary. We present several numerical experiments for our numerical method, which demonstrate the accuracy and robustness of the proposed algorithm. Copyright © 2016 John Wiley & Sons, Ltd.
Electrochemical Performance of MnO2‐based Air Cathodes for Zinc‐air Batteries
Authors: Li G. , Mezaal M. A. , Zhang R. , Zhang K. , Lei L. 
Published: April 2016

AbstractThis paper compares the oxygen reduction on four MnO2‐based air cathodes assembled in home‐made electrochemical cells, with some particular observations on α‐MnO2 cathode. The results show that the catalytic activity decreases in the following order: electrolytic MnO2 (EMD) > natural MnO2 (NMD) > β‐MnO2 > α‐MnO2. The maximum power density of the zinc‐air battery with EMD as the catalyst reaches up to 141.8 mW cm−2 at the current density of 222.5 mA cm−2, which is about 60%, 20% and 10% higher than that of α‐MnO2 (90.0 mW cm−2 at 120.3 mA cm−2), β‐MnO2 (121.5 mW cm−2 at 150.4 mA cm−2) and NMD (128.2 mW cm−2 at 207.8 mA cm−2), respectively. It is believed that its unique crystal structure and biggest BET surface area make EMD have the smallest charge transfer resistance (Rct), thus EMD has the highest activity.
Is Fine‐Grained Simulation Able to Propose New Polyelectrolyte Membranes?
Authors: Fleury A. , Godey F. , Laflamme P. , Ghoufi A. , Soldera A. 
Published: April 2016

AbstractAn extensive understanding in the molecular motions that occur in Nafion® should lead to important development of improved proton exchange membrane for use in fuel cells (PEMFC). As water molecules are added in the system, changes within the Nafion® chain definitely take place. To visualize such a process, molecular dynamics is especially useful. Can information gained at this level of details be useful to propose new molecules, with ultimately better physical properties, such as higher proton conductivity? For this purpose, we first computed non‐bond parameters stemming from the study of the trifluorosufonic acid. They are inserted in the pcff force field. We then applied the procedure developed in our lab to extract the glass transition temperature of Nafion® with different water uptakes. The plasticization effect is first confirmed, fostering a molecular analysis. The particular behavior of the sulfur‐sulfur distance is revealed, guiding the design of new monomers.
Synthesis and Characterization of New Variously Substituted Allylic Phosphates
Authors: Bahri Leila , Barhoumi‐Slimi T. , Sanhoury M. A. K. , Ben Dhia M. T. 
Published: April 2016

ABSTRACTNew allylic phosphates were synthesized through phosphorylation of the corresponding alcohols. These compounds were obtained as mixtures of two (Z and E) isomers in 55–85% yield. They were characterized by multinuclear (1H, 13C, 31P, and 19F) NMR, IR spectroscopy, and HRMS.
Diplopia as a sequel of unilateral neck dissection
Authors: Gupta Madan P. , Sagar Prem , Hota Ashutosh , Kumar Rakesh , Kumar Rajeev 
Published: April 2016

AbstractBackgroundThe purpose of this study was to discuss the underlying etiology of raised intracranial pressure and its sequel after unilateral internal jugular vein ligation. In addition, the management protocol for such rare cases has been discussed along with literature review.MethodsPubMed and Google were used to search the literature for cases of raised intracranial pressure with complications after unilateral internal jugular vein (IJV) ligation. Twelve case reports with 17 patients were identified.ResultsThere were 13 male and 4 female patients ranging between the ages of 26 and 61 years. Headache (n = 12/17; 70.5%), diplopia (n = 10/17; 58.8%), impaired vision (n = 9/17; 52.9%), and aplasia or hypoplasia of the transverse sinus were seen in these patients.ConclusionAlthough very rare, this potential complication after unilateral IJV ligation should be kept in mind. Magnetic resonance venogram (MRV) is the investigation of choice to ascertain the underlying etiology. Conservative management should be started immediately. Surgical options are reserved for patients with progressive symptoms. © 2016 Wiley Periodicals, Inc. Head Neck, 2016 © 2016 Wiley Periodicals, Inc. Head Neck 38:E2475–E2478, 2016
Head and neck chondrosarcomas: Analysis of the Surveillance, Epidemiology, and End Results database
Authors: Ellis Mark A. , Gerry Daniel R. , Byrd J. Kenneth 
Published: April 2016

ABSTRACTBackgroundChondrosarcoma is a rare tumor of the head and neck. Because of the limited clinical data, no studies have conducted a thorough comparison between head and neck chondrosarcomas and those arising at other body sites.MethodsUsing the Surveillance, Epidemiology, and End Results (SEER) database, we compared 682 patients with chondrosarcomas of the head and neck with 4757 patients with non–head and neck chondrosarcomas, evaluating disease‐specific survival (DSS) and overall survival (OS) based on tumor location, histology, grade, stage, and treatment.ResultsHead and neck chondrosarcomas displayed a lower grade (p < .001) and stage (p < .0001) compared with other chondrosarcomas. Overall, chondrosarcomas of the head and neck had significantly higher DSS and OS than non–head and neck chondrosarcomas (p < .001).ConclusionChondrosarcomas of the head and neck display a lower grade and stage compared with other chondrosarcomas. DSS and OS were significantly greater for chondrosarcomas of the head and neck. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1359–1366, 2016
Localized sinonasal mucosal melanoma: Outcomes and associations with stage, radiotherapy, and positron emission tomography response
Authors: Samstein Robert M. , Carvajal Richard D. , Postow Michael A. , Callahan Margaret K. , Shoushtari Alexander N. , Patel Snehal G. , Lee Nancy Y. , Barker Christopher A. 
Published: April 2016

AbstractBackgroundSinonasal mucosal melanoma is a rare neoplasm with a poor prognosis.MethodsRetrospective analysis was conducted on 78 patients with localized sinonasal mucosal melanoma treated at Memorial Sloan Kettering Cancer Center (MSKCC from 1998–2013). Demographic, tumor, imaging, and treatment factors were recorded and survival and disease‐control outcomes were analyzed.ResultsMedian overall survival (OS) and disease‐specific survival (DSS) were 32 and 50 months, respectively. Median locoregional recurrence‐free survival (LRFS) and distant recurrence‐free survival (DRFS) were 43 and 12 months, respectively. Multivariate analysis demonstrated greater OS in nasal cavity tumors and earlier T classification. Radiotherapy (RT) was associated with significantly greater LRFS (5‐years; 35% vs 59%; p = .01), but no difference in OS. Post‐RT positron emission tomography (PET) response was associated with greater OS.ConclusionDistant metastasis is the predominant mode of recurrence in sinonasal mucosal melanoma, but local recurrence remains common. RT is associated with improved local control, but no survival benefit. The prognostic value of post‐RT PET imaging warrants further investigation. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1310–1317, 2016
Comparison of the therapeutic effects of total laryngectomy and a larynx‐preservation approach in patients with T4a laryngeal cancer and thyroid cartilage invasion: A multicenter retrospective review
Authors: Choi Yoon Seok , Park Sang Gon , Song Eun‐Kee , Cho Sang‐Hee , Park Moo‐Rim , Park Keon Uk , Lee Ki‐Hyeong , Song Ik‐Chan , Lee Hyo Jin , Jo Deog‐Yeon , Kim Samyong , Yun Hwan‐Jung ,   on behalf of the Korean South West Oncology Group (KSWOG) Investigators
Published: April 2016

ABSTRACTBackgroundIn T4a laryngeal cancer with thyroid cartilage invasion, no optimal frontline treatment has yet been defined in controlled trials.MethodsWe reviewed data from 89 patients with T4a laryngeal cancer featuring thyroid cartilage invasion who were treated initially with either total laryngectomy (n = 53) or a larynx‐preservation strategy (n = 36).ResultsThe median progression‐free survival (PFS) of the total laryngectomy group had not been attained at the time of analysis and was thus significantly longer than that of the larynx‐preservation group (8.7 months). The median overall survival (OS) of patients who underwent total laryngectomy was 87.2 months, significantly longer than that of the larynx‐preservation group (31.3 months). The survival benefit of primary surgery compared to a larynx‐preservation strategy was more striking in patients of lower N classifications.ConclusionTotal laryngectomy may be a better therapeutic option to treat T4a laryngeal cancer featuring thyroid cartilage invasion, especially in patients exhibiting limited nodal involvement (N0/N1). © 2016 Wiley Periodicals, Inc. Head Neck, 2016 © 2016 Wiley Periodicals, Inc. Head Neck 38:1271–1277, 2016
Relapse status as a prognostic factor in patients receiving salvage surgery for recurrent or residual nasopharyngeal cancer after definitive treatment
Authors: Chee Jeremy , Ting Yohanes , Ong Yew Kwang , Chao Siew Shuen , Loh Kwok Seng , Lim Chwee Ming 
Published: April 2016

AbstractBackgroundThe purpose of this study was to determine the prognostic value of relapse status (recurrent vs residual disease) in patients receiving surgical salvage for nasopharyngeal carcinoma (NPC).MethodsRetrospective review was conducted on 52 patients who underwent salvage surgery for locoregional relapse of NPC. Univariate and multivariate analyses were used to investigate the prognostic value of relapse status.ResultsMedian follow‐up duration was 44.4 months. Mean overall survival (OS) and disease‐free survival (DFS) for patients with NPC with residual and recurrent disease after surgical salvage were 107.4 and 54.4 months, and 83.6 and 34.6 months, respectively (p < .001). This improved survival was demonstrated regardless whether the relapse was at the primary or nodal site. Multivariate analysis revealed that recurrent disease status and nodal disease relapse were independent poor prognostic factors for survival in patients receiving salvage surgery for NPC.ConclusionIn patients undergoing surgical salvage for NPC relapse, residual disease carries a better prognosis than recurrent disease. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1393–1400, 2016
Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification
Authors: Mermod Maxime , Bongiovanni Massimo , Petrova Tatiana V. , Dubikovskaya Elena A. , Simon Christian , Tolstonog Genrich , Monnier Yan 
Published: April 2016

AbstractBackgroundThe use of lymphatic vessel density as a predictor of occult lymph node metastasis (OLNM) in head and neck squamous cell carcinoma (HNSCC) has never been reported.MethodsStaining of the specific lymphatic endothelial cells nuclear marker, PROX1, as an indicator of lymphatic vessel density was determined by counting the number of positive cells in squamous cell carcinomas (SCCs) of the oral cavity and the oropharynx with clinically negative necks. Correlation with histopathological data was established.ResultsPeritumoral PROX1 lymphatic nuclear count significantly correlated with the detection of OLNM in multivariate analysis (p < .005). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of this parameter was 60%, 95%, 85%, and 90%, respectively.ConclusionPeritumoral PROX1 lymphatic nuclear count in primary SCCs of the oral cavity and the oropharynx allows accurate prediction of occult lymph node metastasis. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1407–1415, 2016
Insight into the epidemiology of cutaneous squamous cell carcinoma with perineural spread
Authors: Warren Timothy A. , Whiteman David C. , Porceddu Sandro V. , Panizza Benedict J. 
Published: April 2016

ABSTRACTBackgroundPerineural spread (PNS) of cutaneous squamous cell carcinoma of the head and neck (SCCHN) can be associated with poor outcomes. Disease understanding and awareness is limited leading to delayed diagnosis and treatment. The purpose of this study was to identify epidemiological features of patients with PNS of cutaneous SCCHN.MethodsTumor characteristics and demographics of patients with PNS of cutaneous SCCHN managed through a single institution were collected between 1998 and 2013.ResultsOne hundred twenty patients were included in this study. The majority had a history of skin cancer (85.8%). The median time from primary tumor treatment to PNS symptom onset was 16 months (range, 1–86 months). A total of 34.2% had no perineural invasion (PNI) detected in the primary, and 22.5% had no known primary tumor. Only 5.8% of the patients had nodal involvement at presentation.ConclusionPatients can present with PNS from cutaneous SCCHN with no known primary tumor or with primary tumors without PNI. The majority of patients presented without regional nodal involvement. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1416–1420, 2016
Evaluating sampling efficiency when estimating sediment source contributions to suspended sediment in rivers by fingerprinting
Authors: Clarke Robin T. , Minella Jean P. G. 
Published: April 2016

AbstractA general method is proposed which measures the increase in uncertainty when sampling effort is reduced in sediment fingerprinting. The method gives quantitative measures of how reduced sampling of material in one of the source areas, and/or of suspended sediment in streams, increases the uncertainties in the proportions of sediment contributed from the sources. Because the proportions of sediment contributed by the source areas must add to one, standard errors of the estimated proportions cannot be used as the usual measures of uncertainty: the paper uses instead the volume of the joint 95% confidence region for the estimated proportions. The paper shows how the uncertainty in this volume changes as numbers of suspended sediment samples, and the numbers of samples collected from cropped fields, are reduced by successive steps from 24 (20, in the case of cropped fields) to 16, 12, 8, 4 and 2 samples. As expected, uncertainty increases rapidly as the number of samples – whether of suspended sediment or from cropped fields – is reduced drastically. The pattern of increasing uncertainty is similar both for reductions in suspended sediment sampling, and for reduced sampling from cropped areas. When the number of suspended sediment samples, and the number of samples from cropped fields, are reduced to the same values, the increase in uncertainty from fewer suspended sediment samples was always slightly greater than the increased uncertainty from the reduced sampling of cropped areas, although this finding took no account of differences in the costs of field sampling and laboratory analysis. Copyright © 2016 John Wiley & Sons, Ltd.
Adipose‐derived mesenchymal stromal cells modulate experimental autoimmune arthritis by inducing an early regulatory innate cell signature
Authors: Lopez‐Santalla Mercedes , Menta Ramon , Mancheño‐Corvo Pablo , Lopez‐Belmonte Juan , DelaRosa Olga , Bueren Juan A. , Dalemans Wilfried , Lombardo Eleuterio , Garin Marina I. 
Published: April 2016

AbstractModulation of innate immune responses in rheumatoid arthritis and other immune‐mediated disorders is of critical importance in the clinic since a growing body of information has shown the key contribution of dysregulated innate responses in the progression of the disease. Mesenchymal stromal cells (MSCs) are the focus of intensive efforts worldwide due to their key role in tissue regeneration and modulation of inflammation. In this study, we define innate immune responses occurring during the early course of treatment with a single dose of expanded adipose‐derived MSCs (eASCs) in established collagen‐induced arthritis. eASCs delay the progression of the disease during the early phase of the disease. This is accompanied by a transient induction of Ly6C+ monocytes that differentiate into IL10+F4/80+ cells in arthritic mice. Strikingly, the induced IL10+F4/80+ myeloid cells preferentially accumulated in the draining lymph nodes. This effect was accompanied with a concomitant declining of their frequencies in the spleens. Our results show that eASCs attenuate the arthritic process by inducing an early innate cell signature that involves a transient induction of Ly6C+ monocytes in periphery that differentiate into IL10+F4/80+ macrophages. Our findings demonstrate that early regulatory innate cell responses, involving the monocyte compartment, are targeted by the eASCs during the onset of collagen‐induced inflammation.
Bladder cancer diagnosis from bladder wash by Fourier transform infrared spectroscopy as a novel test for tumor recurrence
Authors: Gok Seher , Aydin Ozge Z. , Sural Yavuz S. , Zorlu Ferruh , Bayol Umit , Severcan Feride 
Published: April 2016

This study proposes Fourier Transform Infrared (FTIR) spectroscopy as a more sensitive, rapid, non‐destructive and operator‐independent analytical diagnostic method for bladder cancer recurrence from bladder wash than other routinely used urine cytology and cystoscopy methods.A total of 136 patients were recruited. FTIR spectroscopic experiments were carried out as a blind study, the classification results of which were then compared with those of cytology and cystoscopy. Firstly, 71 samples (n = 37; bladder cancer and n = 34; control) were studied with transmittance FTIR spectroscopy. After achieving successful differentiation of the groups, to develop a more rapid diagnostic tool and check the reproducibility of the results, the work was continued with different samples (n = 65 as n = 44; bladder cancer and n = 21; control), using the reflection mode (ATR) of FTIR spectroscopy by a different operator. The results revealed significant alterations in moleculer content in the cancer group. Based on the spectral differences, using transmittance FTIR spectroscopy coupled with chemometrics, the diseased group was successfully differentiated from the control. When only carcinoma group was taken into consideration a sensitivity value of 100% was achieved. Similar results were also obtained by ATR‐FTIR spectroscopy. This study shows the power of infrared spectroscopy in the diagnosis of bladder cancer.
magnified image
Synthesis of a poly(ethylene glycol) galloyl sensitizer tip for an ’all‐in‐one' photodynamic device
Authors: Ghogare Ashwini A. , Greer Alexander 
Published: April 2016

This paper describes the synthesis of a specialized silica tip for an optical fiber device capable of delivering all components necessary for photodynamic therapy. Oxygen, light and a cleavable tripolyethylene glycol (PEG)‐galloyl pheophorbide sensitizer are simultaneously delivered by the silica tip, where the tip was synthesized in six steps. A comparison of synthetic steps to reach PEGylated sensitizers bound to fluorinated silica and a previously reported Teflon/polyvinyl alcohol (PVA) nanocomposite (
Ghosh, G. et al.
J. Phys. Chem. B
2015, 119,
4155–
4164) was made. The hydrolytic stability of the attached PEGs and the extent to which the PEG groups enhance solubility will also be discussed. The new triPEG‐galloyl sensitizer has the potential for use in intraoperative pointsource photodynamic therapy which aims for precision treatment of residual disease.
Schematic of the synthesis of a photoactive silica surface. It is composed of fluorinated silica connected to a photo‐releasable sensitizer with short‐chain PEGs.magnified imageSchematic of the synthesis of a photoactive silica surface. It is composed of fluorinated silica connected to a photo‐releasable sensitizer with short‐chain PEGs.
Exposure Matching for Extrapolation of Efficacy in Pediatric Drug Development
Authors: Mulugeta Yeruk , Barrett Jeffrey S. , Nelson Robert , Eshete Abel Tilahun , Mushtaq Alvina , Yao Lynne , Glasgow Nicole , Mulberg Andrew E. , Gonzalez Daniel , Green Dionna , Florian Jeffry , Krudys Kevin , Seo Shirley , Kim Insook , Chilukuri Dakshina , Burckart Gilbert J. 
Published: April 2016

AbstractDuring drug development, matching adult systemic exposures of drugs is a common approach for dose selection in pediatric patients when efficacy is partially or fully extrapolated. This is a systematic review of approaches used for matching adult systemic exposures as the basis for dose selection in pediatric trials submitted to the US Food and Drug Administration (FDA) between 1998 and 2012. The trial design of pediatric pharmacokinetic (PK) studies and the pediatric and adult systemic exposure data were obtained from FDA publicly available databases containing reviews of pediatric trials. Exposure‐matching approaches that were used as the basis for pediatric dose selection were reviewed. The PK data from the adult and pediatric populations were used to quantify exposure agreement between the 2 patient populations. The main measures were the pediatric PK studies’ trial design elements and drug systemic exposures (adult and pediatric). There were 31 products (86 trials) with full or partial extrapolation of efficacy with an available PK assessment. Pediatric exposures had a range of mean Cmax and AUC ratios (pediatric/adult) of 0.63 to 4.19 and 0.36 to 3.60, respectively. Seven of the 86 trials (8.1%) had a predefined acceptance boundary used to match adult exposures. The key PK parameter was consistently predefined for antiviral and anti‐infective products. Approaches to match exposure in children and adults varied across products. A consistent approach for systemic exposure matching and evaluating pediatric PK studies is needed to guide future pediatric trials.