bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature- and wavelength-insensitive parametric amplification enabled by noncollinear achromatic phase-matching
Authors: Tang Daolong , Ma Jingui , Wang Jing , Zhou Bingjie , Xie Guoqiang , Yuan Peng , Zhu Heyuan , Qian Liejia 
Published: October 2016

AbstractOptical parametric chirped-pulse amplification (OPCPA) has been demonstrated to be a promising approach for pushing femtosecond pulses towards ultra-high peak powers. However, the future success of OPCPA strongly relies on the ability to manipulate its phase-matching (PM) configuration. When a high average power pump laser is involved, the thermal effects in nonlinear crystals induce phase-mismatch distortions that pose an inherent limitation on the conversion efficiency. Here, we demonstrate that the noncollinear configuration previously adopted for wavelength-insensitive PM can be employed for temperature-insensitive PM when the noncollinear angle is properly reset. Simultaneous temperature- and wavelength-insensitive PM is realized for the first time by imposing such a temperature-insensitive noncollinear configuration with an angularly dispersed seed signal. Based on the lithium triborate crystal, the proposed noncollinear achromatic PM has a thermal acceptance 6 times larger than that of the conventional wavelength-insensitive noncollinear PM and has a sufficient spectral acceptance to support pulse durations of ~20 fs at 800 nm. These achievements open new possibilities for generating ultra-high peak power lasers with high average power.
Survival of mature T cells depends on signaling through HOIP
Authors: Okamura Kazumi , Kitamura Akiko , Sasaki Yoshiteru , Chung Doo Hyun , Kagami Shoji , Iwai Kazuhiro , Yasutomo Koji 
Published: October 2016

AbstractT cell development in the thymus is controlled by a multistep process. The NF-κB pathway regulates T cell development as well as T cell activation at multiple differentiation stages. The linear ubiquitin chain assembly complex (LUBAC) is composed of Sharpin, HOIL-1L and HOIP, and it is crucial for regulating the NF-κB and cell death pathways. However, little is known about the roles of LUBAC in T-cell development and activation. Here, we show that in T-HOIPΔlinear mice lacking the ubiquitin ligase activity of LUBAC, thymic CD4+ or CD8+ T cell numbers were markedly reduced with severe defects in NKT cell development. HOIPΔlinear CD4+ T cells failed to phosphorylate IκBα and JNK through T cell receptor-mediated stimulation. Mature CD4+ and CD8+ T cells in T-HOIPΔlinear mice underwent apoptosis more rapidly than control T cells, and it was accompanied by lower CD127 expression on CD4+CD24low and CD8+CD24low T cells in the thymus. The enforced expression of CD127 in T-HOIPΔlinear thymocytes rescued the development of mature CD8+ T cells. Collectively, our results showed that LUBAC ligase activity is key for the survival of mature T cells, and suggest multiple roles of the NF-κB and cell death pathways in activating or maintaining T cell-mediated adaptive immune responses.
Genome-wide identification of endogenous RNA-directed DNA methylation loci associated with abundant 21-nucleotide siRNAs in Arabidopsis
Authors: Zhao Jian-Hua , Fang Yuan-Yuan , Duan Cheng-Guo , Fang Rong-Xiang , Ding Shou-Wei , Guo Hui-Shan 
Published: October 2016

AbstractIn Arabidopsis, the 24-nucleotide (nt) small interfering RNAs (siRNAs) mediates RNA-directed DNA methylation (RdDM) and transcriptional gene silencing (TGS) of transposable elements (TEs). In the present study, we examined genome-wide changes in DNA methylation and siRNA accumulation in Arabidopsis induced by expression of the Cucumber mosaic virus silencing suppressor protein 2b known to directly bind to both the 21/24-nt siRNAs as well as their associated Argonaute proteins. We demonstrated a genome-wide reduction of CHH and CHG methylation in the 2b-transgenic plants. We found that 2b suppressed RdDM not only at the previously annotated loci directed by 24-nt siRNAs but also a new set of loci associated with 21/22-nt siRNAs. Further analysis showed that the reduced methylation of TEs and coding genes targeted by 21/22-nt siRNAs was associated with sequestration of the duplex siRNAs by the 2b protein but not with changes in either siRNA production or transcription. Notably, we detected both the deletion and/or the transposition of multicopy TEs associated with 2b-induced hypomethylation, suggesting potential TE reactivation. We propose that the silencing of many TEs in Arabidopsis is controlled by the 24- and 21-nt endogenous siRNAs analogous to Drosophila TE silencing by PIWI-interacting RNAs and siRNAs.
Preparation of pH-responsive hollow poly(MAA-co-EGDMA) nanocapsules for drug delivery and ultrasound imaging
Authors: Hu He , Zhang Xiaofen , Sun Jin , An Lu , Du Jing , Yang Hong , Li Fenghua , Wu Huixia , Yang Shiping 
Published: October 2016

The biocompatible hollow poly(MAA-co-EGDMA) nanocapsules with size of 260 nm shown controlled DOX drug delivery and effective ultrasound imaging.
The Effects of Phonotactic Probability and Neighborhood Density on Adults' Word Learning in Noisy Conditions
Authors: Han Min Kyung , Storkel Holly L. , Lee Jaehoon , Cox Casey 
Published: October 2016

Purpose
Noisy conditions make auditory processing difficult. This study explores whether noisy conditions influence the effects of phonotactic probability (the likelihood of occurrence of a sound sequence) and neighborhood density (phonological similarity among words) on adults' word learning.

Method
Fifty-eight adults learned nonwords varying in phonotactic probability and neighborhood density in either an unfavorable (0-dB signal-to-noise ratio [SNR]) or a favorable (+8-dB SNR) listening condition. Word learning was assessed using a picture naming task by scoring the proportion of phonemes named correctly.

Results
The unfavorable 0-dB SNR condition showed a significant interaction between phonotactic probability and neighborhood density in the absence of main effects. In particular, adults learned more words when phonotactic probability and neighborhood density were both low or both high. The +8-dB SNR condition did not show this interaction. These results are inconsistent with those from a prior adult word learning study conducted under quiet listening conditions that showed main effects of word characteristics.

Conclusions
As the listening condition worsens, adult word learning benefits from a convergence of phonotactic probability and neighborhood density. Clinical implications are discussed for potential populations who experience difficulty with auditory perception or processing, making them more vulnerable to noise.
Accuracy of Self-Reported Estimates of Daily Voice Use in Adults With Normal and Disordered Voices
Authors: Mehta Daryush D. , Cheyne Harold A. , Wehner Asa , Heaton James T. , Hillman Robert E. 
Published: October 2016

Purpose
Accurate estimation of daily patterns of vocal behavior is essential to understanding the role of voice use in voice disorders. Given that clinicians currently rely on patient self-report to assess daily vocal behaviors, this study sought to assess the accuracy with which adults with and without voice disorders can estimate their amount of daily voice use in terms of phonation time.

Method
Eighteen subjects (6 patients, 6 matched members of a control group without voice disorders, 6 low voice users) wore the accelerometer-based Ambulatory Phonation Monitor (APM; model 3200, KayPENTAX, Montvale, NJ) for at least 5 workdays. Subjects were instructed to provide hourly self-reports of time spent talking using a visual analog scale. Spearman correlation coefficients and errors between self-reported and APM-based estimates of phonation time revealed subject- and group-specific characteristics.

Results
A majority of subjects exhibited a significant bias toward overestimating their phonation times, with an average absolute error of 113%. Correlation coefficients between self-reported and APM-based estimates of phonation time ranged from statistically nonsignificant to .91, reflecting large intersubject variability.

Conclusions
Subjects in all 3 groups were moderately accurate at estimating their hourly voice use, with a consistent bias toward overestimation. The results support the potential role that ambulatory monitoring could play in improving the clinical assessment of voice disorders.
UWB 90° phase shifter based on broadside coupler and T‐shaped stub
Authors: Wang Jun , Shen Zhongxiang , Zhao Lei 
Published: October 2016

An UWB 90° phase shifter based on broadside coupler and T‐shaped stub is proposed. Its operation mechanism is explained by the equivalent circuit. The measured results exhibit that the bandwidth is 126.7% with phase deviation within ±6°, and the insertion loss is <1.8 dB over the frequency band from 2.2 to 9.8 GHz. Comparison shows that the proposed design not only achieves the widest bandwidth, but also has low insertion loss and small phase difference. This design is a good candidate for UWB applications due to its low cost, planar structure, and convenient installation.
Designing evaluation plans for health promotion mHealth interventions: a case study of the Milk Man mobile app
Authors: White Becky K. , Burns Sharyn K. , Giglia Roslyn C. , Scott Jane A. 
Published: October 2016

Evaluating complex health promotion interventions that use mobile apps requires comprehensive and adaptive evaluation plans. As mobile usage becomes increasingly sophisticated and personalised, broad evaluation plans are important in determining the impact and efficacy of a mobile health (mHealth) app. Evaluation should consider user feedback and outcome measures, as well as examine elements such as the robustness of the technology, the intervention principles and engagement strategies, and the interaction of the user with the technology. This paper introduces four mHealth evaluation models and tools and describes the evaluation plan that has been developed for Milk Man, a breastfeeding app targeting new and expectant fathers. Milk Man is a socially connected, gamified app that is being tested in a large Randomised Control Trial (RCT). While there is a need for mobile apps to be evaluated in adequately powered RCTs, trialling mobile apps over a long period of time presents challenges. Incorporating robust evaluation design will help ensure that technological performance, app intervention principles, as well as health and behavioural outcomes are measured. The detail and scope of the Milk Man app evaluation plan will ensure the findings add to the evidence base and have broad relevance to health promotion practitioners.So what?Evidence about the efficacy of mHealth interventions is an emerging area and appropriate evaluation skills are needed. This paper illustrates an evaluation planning approach for mHealth interventions that could be adapted for use by health promotion practitioners and researchers.
Differential growth triggers mechanical feedback that elevates Hippo signaling
Authors: Pan Yuanwang , Heemskerk Idse , Ibar Consuelo , Shraiman Boris I. , Irvine Kenneth D. 
Published: October 2016

Significance
To form organs of correct size and proportion, growth must be tightly controlled. Previous studies have characterized how biochemical signals influence organ growth; this report describes an interrelationship between tissue mechanics and organ growth. We show that differential growth leads to accumulation of mechanical stress within tissues and describe both theoretically and experimentally how this mechanical stress can result in reduced tension within faster-growing cells. We show how this reduced tension can increase the activity of the Hippo signaling pathway, which decreases growth rates, and show that this mechanism influences patterns of cell proliferation in vivo. Our results support and extend a theoretical model, termed “mechanical feedback,” that described the relationship between growth rates and tissue mechanics.
A propelling neutron star in the enigmatic Be-star γ Cassiopeia
Authors: Postnov K. , Oskinova L. , Torrejón J.M. 
Published: October 2016

Abstract
The enigmatic X-ray emission from the bright optical star, γ Cassiopeia, is a long-standing problem. γ Cas is known to be a binary system consisting of a Be-type star and a low-mass (M ∼ 1 M⊙) companion of unknown nature orbiting in the Be-disk plane. Here we apply the quasi-spherical accretion theory onto a compact magnetized star and show that if the low-mass companion of γ Cas is a fast spinning neutron star, the key observational signatures of γ Cas are remarkably well reproduced. Direct accretion onto this fast rotating neutron star is impeded by the propeller mechanism. In this case, around the neutron star magnetosphere a hot shell is formed that emits thermal X-rays in qualitative and quantitative agreement with observed properties of the X-ray emission from γ Cas. We suggest that γ Cas and its analogs constitute a new subclass of Be-type X-ray binaries hosting rapidly rotating neutron stars formed in supernova explosions with small kicks. The subsequent evolutionary stage of γ Cas and its analogs should be the X Per-type binaries comprising low-luminosity slowly rotating X-ray pulsars. The model explains the enigmatic X-ray emission from γ Cas, and also establishes evolutionary connections between various types of rotating magnetized neutron stars in Be-binaries.
Evidence for strong evolution in galaxy environmental quenching efficiency between z = 1.6 and z = 0.9
Authors: Nantais Julie B. , Muzzin Adam , van der Burg Remco F. J. , Wilson Gillian , Lidman Chris , Foltz Ryan , DeGroot Andrew , Noble Allison , Cooper Michael C. , Demarco Ricardo 
Published: October 2016

Abstract
We analyse the evolution of environmental quenching efficiency, the fraction of quenched cluster galaxies that would be star-forming if they were in the field, as a function of redshift in 14 spectroscopically confirmed galaxy clusters with 0.87 &lt; $z$ &lt; 1.63 from the Spitzer Adaptation of the Red-Sequence Cluster Survey (SpARCS). The clusters are the richest in the survey at each redshift. Passive fractions rise from $42_{-13}^{+10}$% at $z$ ∼ 1.6 to $80_{-9}^{+12}$% at $z$ ∼ 1.3 and $88_{-3}^{+4}$% at $z$ &lt; 1.1, outpacing the change in passive fraction in the field. Environmental quenching efficiency rises dramatically from $16_{-19}^{+15}$% at $z$ ∼ 1.6 to $62_{-15}^{+21}$% at $z$ ∼ 1.3 and $73_{-7}^{+8}$% at $z$ ≲ 1.1. This work is the first to show direct observational evidence for a rapid increase in the strength of environmental quenching in galaxy clusters at $z$ ∼ 1.5, where simulations show cluster-mass halos undergo non-linear collapse and virialisation.
1 Clement
Authors: Maier Harry 
Published: October 2016

1 Clement is a letter attributed to Clement of Rome (fl. second half of the 1st century ce). It is from a single hand, comprising sixty-five chapters, written from a body of Christ followers in Rome to those in Corinth. It is a long and often rambling writing whose chief aim does not appear until chapters 39–44. Clement, on behalf of the Roman community, advises his audience to restore harmony to the Corinthian church through the reappointment of leaders some have deposed. Parts of the early church treated it as canonical. In Codex Alexandrinus it appears, together with 2 Clement, directly after the Book of Revelation, and in a Syriac manuscript both writings appear before the Apocalypse. Clement of Alexandria quoted the letter as a canonical text. It nowhere states it is from Clement but there are three warrants for accepting the attribution: in the 2nd century Dionysius of Corinth cited him as its author; the Shepherd of Hermas, a document many argue to be contemporary with the writing, identifies a Clement who has the responsibility of sending writings to other cities (Vision 2.4.3), arguably a direct allusion to 1 Clement; the possibility of association as a freed person with the aristocratic family of Titus Flavius Clement and his wife Flavia Domitilla, the latter of whom Eusebius of Caesarea records as persecuted by Domitian for Christian belief. Its chief importance is that it is the earliest preserved Christian letter outside the New Testament. As a text that is contemporary with, if not earlier than, several canonical writings, it offers a snapshot of emergent Christianity in Rome and Corinth. Since its discovery it has played a central role in debates concerning the earliest conceptions of leadership in the ancient church and it is here where most attention has been directed. Scholarly study has also centered on its uses of rhetorical conventions, philosophical traditions, liturgical formulae, and lengthy Old Testament quotations, as well as possible echoes of New Testament texts.
Jerome Bruner
Authors: Takaya Keiichi 
Published: October 2016

Jerome Seymour Bruner was born on 1 October 1915 in New York City, and he died on 5 June 2016 in New York City. He is one of the most influential figures in psychology, cognitive science, and education in the past one hundred years. Although he was a psychologist by training, his interests spanned over a wide range of disciplines and issues, including psychology, philosophy, linguistics, education, literature, and law. His research and writings were also notable for their interdisciplinary and collaborative approaches; he freely borrowed findings and insights from other areas, and, in return, he inspired not only psychologists but also philosophers, educators, and anthropologists. He led the cognitive revolution and the cultural turn in psychology and the curriculum reform movement, and he was involved (albeit indirectly) in the introduction of Head Start in the United States. Bruner wrote in his 1983 autobiography that he was “an intellectual first and a scientist in support. . . . I used psychology to pursue matters that existed for me in their own right. Psychology was (and remains) only one way to use mind in behalf of these pursuits” (Bruner 1983a, cited under General Overviews, p. 77). His colleagues and collaborators included people in almost every field of intellectual activity, and his research locations were widespread from laboratories in Harvard to villages in Senegal, nursery schools in Oxfordshire, and preschools in Reggio Emilia, Italy. His overall interests lay in how the human mind works and develops in sociocultural contexts and by acquiring cultural tools. His interests lay also in developing finer research methods that are more attuned to the human mind in real, lived experiences. In his early career in the 1940s and 1950s, he worked on the foundations and limits of human perception and thought. In doing so, his “New Look” psychology critiqued behaviorism for being narrowly scientistic and devised clever research methods in seemingly standard experimental studies. Dissatisfaction with the existing psychological approaches had led him to initiate the cognitive revolution in the 1950s, but he later became disenchanted with cognitive science’s increasing reliance on computer or information-processing models in understanding how the human mind works. More recently, his research focused on the role of narrative in our individual thoughts and collective culture.
Probiotics-mediated suppression of cancer
Authors: So Stephanie S.Y. , Wan Murphy L.Y. , El-Nezami Hani 
Published: October 2016

Purpose of review
Probiotics can be used as an adjuvant for cancer prevention or/and treatment through their abilities to modulate intestinal microbiota and host immune response. Although most of the recent reviews have focused on the potential role of probiotics against colon cancer, only few of them include the probiotic effect on extraintestinal cancers. The present review covers the most important findings from the literature published during the past 20 months (from January 2015 to August 2016) regarding the probiotics-mediated suppression of both gastrointestinal and extraintestinal cancers and the underlying mechanisms.

Recent findings
A comprehensive literature search in Pubmed, Science direct and Google scholar databases was conducted to locate all relevant articles that investigated the effect of probiotics on prevention/treatment of both gastrointestinal and extraintestinal cancers. Different mechanisms for the beneficial effects of probiotics against cancer were also discussed, mainly via modulation of gut microbiota which thereby influences host metabolism and immunity.

Summary
Despite laboratory-based studies having demonstrated encouraging outcomes that probiotics possess antitumor effects, the benefits should not be exaggerated before we get more results from human clinical trials. These are very important before the medical community can accept the use of probiotics as an alternative therapy for cancer control.
Prevention and Management of Injection-Related Adverse Effects in Facial Aesthetics: Considerations for ATX-101 (Deoxycholic Acid Injection) Treatment
Authors: Fagien Steven , McChesney Patricia , Subramanian Meenakshi , Jones Derek H. 
Published: October 2016

Abstract
ATX-101 (deoxycholic acid injection; Kythera Biopharmaceuticals, Inc. [an affiliate of Allergan plc, Dublin, Ireland]) was approved in 2015 in the United States (Kybella) and Canada (Belkyra) for submental fat reduction. As expected, injection-site reactions such as pain, swelling, and bruising, which were mostly mild or moderate and transient, were common adverse events (AEs) reported in clinical trials. An exploratory Phase 3b study investigating interventions for management of injection-site AEs associated with ATX-101 treatment was recently completed. Based on its results, literature review, and our clinical experiences, we have put forward considerations for management of AEs associated with ATX-101 treatment in clinical practice. Pretreatment with oral ibuprofen and/or acetaminophen an hour before treatment and preinjection with epinephrine-containing buffered lidocaine 15 minutes before treatment can help with management of pain and bruising. Cold application to the treated area before and immediately after the procedure may help to reduce pain (if local anesthetic preinjection is not performed) and swelling. Discontinuing medications/supplements that result in increased anticoagulant or antiplatelet activity 7 to 10 days before ATX-101 treatment, when possible, can reduce the risk of bruising. In summary, injection-site AEs associated with ATX-101 treatment can be effectively managed with commonly used interventions.
SMOKING IS A RISK FACTOR FOR PROLIFERATIVE VITREORETINOPATHY AFTER TRAUMATIC RETINAL DETACHMENT
Authors: Eliott Dean , Stryjewski Tomasz P. , Andreoli Michael T. , Andreoli Christopher M. 
Published: October 2016

Purpose:
To determine the incidence of retinal redetachment due to proliferative vitreoretinopathy after open-globe trauma in smokers and nonsmokers.

Methods:
A total of 892 patients comprising 893 open-globe injuries, in whom 255 eyes were diagnosed with a retinal detachment, and 138 underwent surgical repair were analyzed in a retrospective case–control study. Time to redetachment was examined using the Kaplan–Meier method and analysis of risk factors was analyzed using Cox proportional hazards modeling.

Results:
Within one year after retinal detachment surgery, 47% (95% CI, 39–56%) of all 138 repaired retinas redetached because of proliferative vitreoretinopathy. Being a smoker was associated with a higher rate of detachment (adjusted hazard ratio 1.96, P = 0.01). As shown in previous studies, the presence of proliferative vitreoretinopathy at the time of surgery was also an independent risk factor for failure (adjusted hazard ratio 2.13, P = 0.005). Treatment with vitrectomy-buckle compared favorably to vitrectomy alone (adjusted hazard ratio 0.58, P = 0.04). Only 8% of eyes that redetached achieved a best-corrected visual acuity of 20/200 or better, in comparison to 44% of eyes that did not redetach (P < 0.001).

Conclusion:
Proliferative vitreoretinopathy is a common complication after the repair of retinal detachment associated with open-globe trauma, and being a smoker is a risk factor for redetachment. Further study is needed to understand the pathophysiologic mechanisms underlying this correlation.