bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short‐chain acyl‐CoA dehydrogenase deficiency: from gene to cell pathology and possible disease mechanisms
Authors: Nochi Zahra , Olsen Rikke Katrine Jentoft , Gregersen Niels 
Published: May 2017

AbstractShort‐chain acyl‐CoA dehydrogenase deficiency (SCADD) is an inherited disorder of mitochondrial fatty acid oxidation that is characterized by the presence of increased butyrylcarnitine and ethylmalonic acid (EMA) concentrations in plasma and urine. Individuals with symptomatic SCADD may show relatively severe phenotype, while the majority of those who are diagnosed through newborn screening by tandem mass spectrometry may remain asymptomatic. As such, the associated clinical symptoms are very diverse, ranging from severe metabolic or neuromuscular disabilities to asymptomatic. Molecular analysis of affected individuals has identified rare gene variants along with two common gene variants, c.511C > T and c.625G > A. In vitro studies have demonstrated that the common variants as well as the great majority of rare variants, which are missense variants, impair folding, that may lead to toxic accumulation of the encoded protein, and/or metabolites, and initiate excessive production of ROS and chronic oxidative stress. It has been suggested that this cell toxicity in combination with yet unknown factors can trigger disease development. This association and the full implications of SCADD are not commonly appreciated. Accordingly, there is a worldwide discussion of the relationship of clinical manifestation to SCADD, and whether SCAD gene variants are disease associated at all. Therefore, SCADD is not part of the newborn screening programs in most countries, and consequently many patients with SCAD gene variants do not get a diagnosis and the possibilities to be followed up during development.
Reproduction compromises adaptive immunity in a cyprinid fish
Authors: Krams Indrikis A. , Rumvolt Katariina , Saks Lauri , Krams Ronalds , Elferts Didzis , Vrublevska Jolanta , Rantala Markus J. , Kecko Sanita , Cīrule Dina , Luoto Severi , Krama Tatjana 
Published: May 2017

AbstractVertebrates differ in their ability to mount an adaptive immune response to novel antigens. Bioenergetic resources available to an organism are finite; investment in reproduction compromises immune function and may therefore affect critical life history trade‐offs. We tested whether reproduction impairs the ability to produce an antibody response against a novel antigen in roach (Rutilus rutilus). The antigen approach has rarely been used in fish studies, and the ability to produce an antibody response during reproductive season has never been tested in cyprinid fish before. The fish in an experimental group were injected with a Brucella abortus (BA) antigen, while the fish in a control group were injected with an isotonic saline solution. Blood samples were extracted from all the fish to obtain the total number and proportion of blood cells such as lymphocytes, neutrophils and antioxidant glutathione. The groups were tested during the spawning season and one week after it had ended. The roach were unable to mount an immune response during spawning but produced a robust response after it. We conclude that reproduction is costly in roach, as indicated by the increased concentration of neutrophils in fish injected with BA during spawning, as well as the negative associations between neutrophil counts and glutathione levels. This study demonstrates the potential of BA antigen as a research tool in experimental research on fish ecological immunology.
Big data
Authors: van der Poel Henk G. 
Published: May 2017

Samenvatting
Ook in de Nederlandse urologie dringt het begrip big data langzaam door. In dit abstractnummer een paar mooie voorbeelden. Geven meer data ook altijd meer inzicht? Dat blijft de vraag. In veel gevallen levert deze retrospectieve manier van onderzoek een leuk overzicht van de praktijk, maar niet altijd een verklaring voor de bevindingen.
The impact of extracurricular activities participation on youth delinquent behaviors: An instrumental variables approach
Authors: Han Sehee , Lee Jonathan , Park Kyung‐Gook 
Published: May 2017

ABSTRACTThe purpose of this study was to examine the association between extracurricular activities (EA) participation and youth delinquency while tackling an endogeneity problem of EA participation. Using survey data of 12th graders in South Korea (n = 1943), this study employed an instrumental variables approach to address the self‐selection problem of EA participation as the data for this study was based on an observational study design. We found a positive association between EA participation and youth delinquency based on conventional regression analysis. By contrast, we found a negative association between EA participation and youth delinquency based on an instrumental variables approach. These results indicate that caution should be exercised when we interpret the effect of EA participation on youth delinquency based on observational study designs.
Longitudinal evaluation of criteria for subjective cognitive decline and preclinical Alzheimer's disease in a memory clinic sample
Authors: Eckerström Marie , Göthlin Mattias , Rolstad Sindre , Hessen Erik , Eckerström Carl , Nordlund Arto , Johansson Boo , Svensson Johan , Jonsson Michael , Sacuiu Simona , Wallin Anders 
Published: May 2017

AbstractIntroductionSubjective cognitive decline (SCD) and biomarker‐based “at‐risk” concepts such as “preclinical” Alzheimer's disease (AD) have been developed to predict AD dementia before objective cognitive impairment is detectable. We longitudinally evaluated cognitive outcome when using these classifications.MethodsMemory clinic patients (n = 235) were classified as SCD (n = 122): subtle cognitive decline (n = 36) and mild cognitive impairment (n = 77) and subsequently subclassified into SCDplus and National Institute on Aging–Alzheimer's Association (NIA‐AA) stages 0 to 3. Mean (standard deviation) follow‐up time was 48 (35) months. Proportion declining cognitively and prognostic accuracy for cognitive decline was calculated for all classifications.ResultsAmong SCDplus patients, 43% to 48% declined cognitively. Among NIA‐AA stage 1 to 3 patients, 50% to 100% declined cognitively. The highest positive likelihood ratios (+LRs) for subsequent cognitive decline (+LR 6.3), dementia (+LR 3.4), and AD dementia (+LR 6.5) were found for NIA‐AA stage 2.DiscussionIn a memory clinic setting, NIA‐AA stage 2 seems to be the most successful classification in predicting objective cognitive decline, dementia, and AD dementia.
Multiple organ dysfunction syndrome (MODS) prediction score in multi-trauma patients
Authors: Rendy Leo , Sapan Heber B. , Kalesaran Laurens T.B. 
Published: May 2017

Abstract

Background
Multiple organ dysfunction syndrome (MODS) in patients with major trauma remains a frequent and devastating complication in emergency departments and intensive care units. Easily and accurately identifying patients at risk for MODS post-injury, especially in multi-trauma cases, is important. The aim of this study was to develop an instrument to predict the development of MODS in adult multi-trauma patients using clinical and laboratory data available in the first 24 h after trauma.

Methods
We prospectively enrolled adult multi-trauma patients with Injury Severity Score (ISS) ≥16, between 16 and 65 years old, admitted to four academic Level-I trauma centers for 1 year between September 2014 and 2015. Sequential organ failure assessment score was used to determine MODS during hospitalization. A risk score was created from the final regression model consisting of significant variables as MODS predictors.

Result
During the period of the study, 98 multi-trauma patients were included. The mean age was 35.2 years, and most were male (85.71%). The mean ISS was 23.6, mostly (76.53%) caused by blunt injury mechanism. MODS occurred in 43 patients (43.87%). The prediction risk score consists of Revised Trauma Score (<7.25) and lactate level ≥2.75 mmol/L. This study also verified several independent risk factors for post-multi-trauma MODS such as ISS >25, presence of systemic inflammatory response syndrome, shock grade 2 or more, and white blood cells >12,000.

Conclusion
We derived a novel simple and applicable instrument to predict MODS in adults following multi-trauma. The use of this scoring system may allow early identification of trauma patients who are at risk for MODS and result in more aggressive targeted resuscitation and damage control surgery.

Trial registration
ISCRTN ISRCTN16661943. 09/11/2016 retrospectively registered.

Highlights
Reflex syncope: Diagnosis and treatment
Authors: Sutton Richard 
Published: May 2017

AbstractFor the diagnosis of reflex syncope, diligent history‐building with the patient and a witness is required. In the Emergency Department (ED), the assessment of syncope is a challenge which may be addressed by an ED Observation Unit or by a referral to a Syncope Unit. Hospital admission is necessary for those with life‐threatening cardiac conditions although risk stratification remains an unsolved problem. Other patients may be investigated with less urgency by carotid sinus massage (>40 years), tilt testing, and electrocardiogram loop recorder insertion resulting in a clear cause for syncope. Management includes, in general terms, patient education, avoidance of circumstances in which syncope is likely, increase in fluid and salt consumption, and physical counter‐pressure maneuvers. In older patients, those that will benefit from cardiac pacing are now well defined. In all patients, the benefit of drug therapy is often disappointing and there remains no ideal drug. A role for catheter ablation may emerge for the highly symptomatic reflex syncope patient.
Numerical investigations to suppress thermal deformation of the large deployable reflector during earth eclipse in space
Authors: Shoji Kaori , Isobe Daigoro , Usui Motofumi 
Published: May 2017

ABSTRACTIn space, structures encounter various severe environments, including severe thermal conditions. The signal level of the radio wave from the Large Deployable Reflector (LDR) mounted on the Engineering Test Satellite-VIII (ETS-VIII) was observed to change during an Earth eclipse. This phenomenon was assumed to be caused by the thermal deformation of the LDR. Therefore, in this study, a means to suppress the thermal deformation is proposed and demonstrated by focusing on the internal force generated at the springs used to deploy the antenna. According to the numerical results obtained from finite element analyses, the thermal deformations at all apices that support the reflectors were suppressed at a high correction rate by adjusting the coefficients of thermal expansion in the structural members and by controlling spring forces differently in four areas depending on the distances from the constraint point.
A life-history theory perspective on obesity
Authors: Dittmann Andrea G. , Maner Jon K. 
Published: May 2017

AbstractWe extend Nettle et al.’s insurance hypothesis (IH) argument, drawing upon life-history theory (LHT), a developmental evolutionary perspective that documents downstream consequences of early-life exposure to unpredictable environments. We discuss novel evidence consistent with both IH and LHT, suggesting that early-life exposure to unpredictable environments is associated with reduced engagement in weight management behaviors and a greater probability of adulthood obesity.
Potential psychological accounts for the relation between food insecurity and body overweight
Authors: Ert Eyal , Heiman Amir 
Published: May 2017

AbstractWe suggest two psychological mechanisms, temporal discounting and feeling of resource scarcity, for explaining the relation between food insecurity and body overweight. We demonstrate how Nettle et al.’s findings could be explained, post hoc, by each of these accounts, suggesting that their data are not rich enough to allow identification of mechanisms that underlie food insecurity and overweight relationship.
Towards a behavioural ecology of obesity
Authors: Higginson Andrew D. , McNamara John M. , Dall Sasha R. X. 
Published: May 2017

AbstractAddressing the obesity epidemic depends on a holistic understanding of the reasons that people become and maintain excessive fat. Theories about the causes of obesity usually focus proximately or evoke evolutionary mismatches, with minimal clinical value. There is potential for substantial progress by adapting strategic body mass regulation models from evolutionary ecology to human obesity by assessing the role of information.
Predicting human adiposity – sometimes – with food insecurity: Broaden the model for better accuracy
Authors: Hill Sarah E. , Proffitt Leyva Randi P. , DelPriore Danielle J. 
Published: May 2017

AbstractThe target article explores the role of food insecurity as a contemporary risk factor for human overweight and obesity. The authors provide conditional support for the insurance hypothesis among adult women from high-income countries. We consider the potential contribution of additional factors in producing variation in adiposity patterns between species and across human contexts.
Anorexia: A perverse effect of attempting to control the starvation response
Authors: Nesse Randolph M. 
Published: May 2017

AbstractStarvation arouses evolved protective mechanisms including binge eating and increased metabolic efficiency and fat storage. When aroused by dieting, the experiences of out-of-control eating, increased appetite, and increased fat storage arouse greater fears of obesity, spurring renewed attempts to restrict intake severely. The resulting positive feedback cycle escalates into bulimia for many, and anorexia in a few.
Obesity as self-regulation failure: A “disease of affluence” that selectively hits the less affluent?
Authors: Sacco Pier Luigi 
Published: May 2017

AbstractAn effect of the long-term cycle of industrial and post-industrial global development is the increasingly generalized access to abundant and diversified food sources. This poses a substantial problem of self-regulation that mainly affects the less affluent and whose failures may play an important role in the explanation of the increasing social incidence of overweight and obesity problems.
Obesity is not just elevated adiposity, it is also a state of metabolic perturbation
Authors: Wells Jonathan CK 
Published: May 2017

AbstractNettle et al. miss the crucial difference between adaptive models of storing energy and explanations for the pathological metabolic state of obesity. I suggest that the association of food insecurity with obesity in women from industrialized settings is most likely due to reverse causation: Poverty reduces agency to resist obesogenic foods, and this scenario is compounded by perturbations of insulin metabolism stemming from high adiposity and lipogenic diets.
Adaptive principles of weight regulation: Insufficient, but perhaps necessary, for understanding obesity
Authors: Nettle Daniel , Andrews Clare , Bateson Melissa 
Published: May 2017

AbstractWe reflect on the major issues raised by a thoughtful and diverse set of commentaries on our target article. We draw attention to the need to differentiate between ultimate and proximate explanation; the insurance hypothesis (IH) needs to be understood as an ultimate-level argument, although we welcome the various suggestions made about proximate mechanisms. Much of this response is concerned with clarifying the interrelationships between adaptationist explanations like the IH, constraint explanations, and dysfunction explanations, in understanding obesity. We also re-examine the empirical evidence base, concurring that it is equivocal and only partially supportive. Several commentators offer additional supporting evidence, whereas others propose alternative explanations for the evidence we reviewed and suggest ways that our current knowledge could be strengthened. Finally, we take the opportunity to clarify some of the assumptions and predictions of our formal model.
Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children
Authors: Wade Mark , Prime Heather , Hoffmann Thomas J. , Schmidt Louis A. , O'Connor Thomas G. , Jenkins Jennifer M. 
Published: May 2017

AbstractGenetic variation in the oxytocin receptor gene (OXTR) is associated with several psychiatric conditions characterized by deficits in executive functioning (EF). A specific OXTR variant, rs2254298, has previously been associated with brain functioning in regions implicated in EF. Moreover, birth weight variation across the entire range is associated with individual differences in cortical structure and function that underlie EF. This is the first study to examine the main and interactive effect between rs2254298 and birth weight on EF in children. The sample consisted of 310 children from an ongoing longitudinal study. EF was measured at age 4.5 using observational tasks indexing working memory, cognitive flexibility, and inhibitory control. A family-based design that controlled for population admixture, stratification, and nongenomic confounds was employed. A significant genetic association between rs2254298 and EF was observed, with more copies of the major allele (G) associated with higher EF. There was also a significant interaction between rs2254298 and birth weight, such that more copies of the major allele in combination with higher birth weight predicted better EF. Findings suggest that OXTR may be associated with discrete neurocognitive abilities in childhood, and these effects may be modulated by intrauterine conditions related to fetal growth and development.
Executive Functioning in Pedophilia and Child Sexual Offending
Authors: Massau Claudia , Tenbergen Gilian , Kärgel Christian , Weiß Simone , Gerwinn Hannah , Pohl Alexander , Amelung Till , Mohnke Sebastian , Kneer Jonas , Wittfoth Matthias , Ristow Inka , Schiltz Kolja , Beier Klaus M. , Ponseti Jorge , Walter Martin , Kruger Tillmann H.C. , Walter Henrik , Schiffer Boris 
Published: May 2017

AbstractObjectives: Pedophilia (P) is a psychiatric disease associated with sexual attraction toward children and often accompanied by child sexual offending (CSO). Consequently, it is important to address the understanding of executive dysfunctions that may increase the probability of CSO. Moreover, this research field has been lacking to disentangle executive deficits associated with pedophilia (as a deviant sexual preference) from those associated with CSO (as a deviant sexual behavior). Methods: The German multi-sided research network NeMUP offers the opportunity to overcome these limitations. By applying the Cambridge Automated Neuropsychological Test Battery in four carefully matched groups of men: (1) pedophiles with (N=45) and (2) without (N=45) a history of sexual offending against children; (3) child molesters without pedophilia (N=19), and (4) non-offending controls (N=49), we were able to analyze executive functioning in pedophilia and CSO independently. Results: Both CSO groups as compared to both non-CSO groups exhibited worsened response inhibition ability. However, only non-pedophilic offenders showed additionally disabled strategy use ability. Regarding set-shifting abilities, the P+CSO group showed the best performance. We also found that performances were affected by age: only in pedophiles, response inhibition worsened with age, while age-related deficits in set-shifting abilities were restricted to non-pedophilic participants. The latter also differentiated between both sexual preference groups. Conclusions: Our results are the first to demonstrate that executive dysfunctions are related to offense status rather than pedophilic preference. Furthermore, there was evidence for differentiating age and performance correlations between pedophiles and non-pedophiles, which warrants further investigation. (JINS, 2017, 23, 460–470)
Reproductive and pituitary-adrenal axis parameters in normal and prenatally stressed prepubertal blue foxes (Alopex lagopus)
Authors: Osadchuk L. V. , Braastad B. O. , Hovland A. L. , Bakken M. 
Published: May 2017

AbstractMan-animal relationships are involved in the process of fox domestication. Handling being an important part of man-animal contacts, causes stress responses in farm-bred blue foxes. The purpose of this study was to determine how prenatal stress induced by handling pregnant vixens influences certain morphometric and hormonal parameters of adrenocortical and gonadal function in the prepubertal offspring. Blue fox females were subjected to daily handling sessions, each of 1 min, in the last trimester of pregnancy (term = 52 days). Plasma concentrations of ACTH, cortisol, progesterone, oestradiol and testosterone, as well as the in vitro adrenal and gonadal production of steroids were measured by radio-immunoassay in control (C, no. = 56) and prenatally stressed (PS, no. = 56) blue fox cubs of both sexes at the age of 6 to 7 months. Prenatal stress decreased plasma concentration of cortisol (C: 31·0 (s.e. 4·3) v. PS: 22·7(s.e. 1·6) ng/ml, P < 0·05) as well as progesterone (C: 1·00(s.e. 0·10) v. PS: 0·65(s.e. 0·05) ng/ml, P < 0·05) in female cubs. Prenatal stress did not cause any changes in adrenal or gonadal weights, plasma concentrations of testosterone or oestradiol, or in vitro adrenal or gonadal steroid production, in either sex. It is concluded that persistent handling of pregnant blue foxes did not affect the prepubertal development of the reproductive system but resulted in disregulation in the hypothalamic-pituitary-adrenal axis in the female offspring.
Efficiency of vaginal electrical resistance measurements for oestrous detection and insemination in Rathi cows
Authors: Meena R. S. , Sharma S. S. , Purohit G. N. 
Published: May 2017

AbstractThe efficiency of vaginal electrical resistance (VER) measurements for oestrous detection was determined in four experiments. The mean VER during oestrus, metoestrus, dioestrus, pro-oestrus and anoestrus was 32·68±0·46, 41·26±1·17, 50·23±0·55, 43·52±0·54 and 55·86±0·57 ohms, respectively. There were significant (P < 0·01) differences between VERs at the different oestrous cycle stages, except those during pro-oestrus and metoestrus which were similar. Twelve cows were induced in oestrus using prostaglandin (PG) administration to study the changes in VER during the peri-oestrus period. VER values changed both on a within-day (P < 0·05) and day-today (P < 0·001) basis following PG administration. Of the eight cows that responded, all were classified as in oestrus by VER in comparison to five detected in oestrus by a teaser bull. There was a significant association between VER and probability of conception (P < 0·01). Conception rates were 84, 61 and 20% when animals were inseminated at VER ranges of 26 to 30, 31 to 35 and 36 to 40 ohms, respectively. In the final experiment VER was recorded each day at the time of milking in 22 cyclic cows for 60 days. Animals were inseminated when the VER declined below 35 ohms. Of these 22 cows five cows showed overt signs of oestrus and 11/22 (50%) became pregnant. Twenty-one days post AI, five cows returned to oestrus, based on low VER, whereas 17 continued to show a high VER but eight of these (8/17) were subsequently classified as non-cyclic. It is concluded that VER can effectively be used for oestrus detection and identification of the optimum time for insemination but has limited value for pregnancy diagnosis. Cows should be inseminated when a VER reading of less than 36 ohms is recorded.