bluuebunny/crossref_metadata_2025_split huggingface dataset:
The interaction between 5-HTTLPR genotype and ruminative thinking on BMI
Authors: Schepers Robbie , Markus C. Robert 
Published: October 2017

AbstractNegative affect or stress is often found to increase energy intake for high palatable energy-rich foods and hence weight gain. Reduced brain serotonin (5-HT) function is known to increase stress vulnerability and the risk for eating-related disturbances. A short (S) allele polymorphism in the serotonin transporter gene (5-HTTLPR) is associated with a less efficient functioning brain serotonin system and therefore higher stress vulnerability. It has been suggested that this genotype may be directly linked to an increased risk for weight gain and/or obesity. However, a high amount of variability has been apparent in replicating such a direct gene on weight gain relationship. A most recent suggestion is that this gene by weight relationship might be moderated by an additional (cognitive) vulnerability factor involving repetitive negative thinking (rumination). Our objective was to investigate whether the S-allele of 5-HTTLPR contributes to weight gain particularly in high cognitive ruminating individuals. A total of 827 healthy young male and female college students (aged 21·3 (sd 3·0) years; BMI 16–41·7 kg/m2) were genotyped for the 5-HTTLPR polymorphism and assessed for rumination (Event Related Ruminative Index) and body weight. In line with the hypothesis, a hierarchical regression model showed that higher BMI scores were observed in specifically high ruminating S'-carriers (P=0·031, f²=0·022). These results suggest that cognitive rumination may be a critical moderator of the association between 5-HTTLPR and body mass.
High-dose enoxaparin in the treatment of abdominal angiostrongyliasis in Swiss mice
Authors: Sandri A.S.S. , Rodriguez R. , Costa M.M. , Porto S.M. , Schwingel D. , Vieira M.I.B. 
Published: October 2017

AbstractAbdominal angiostrongyliasis (AA) is caused by Angiostrongylus costaricensis, which inhabits mesenteric arteries. There is no drug treatment for AA, and since intestinal infarction due to thrombi is one of the main complications of the disease, the use of anticoagulants may be a treatment option. Thus, we aimed to assess the effect of high doses of enoxaparin on the prevention of ischaemic intestinal lesions and on the survival of mice infected with A. costaricensis. Twenty-four mice were infected with L3 of A. costaricensis and divided equally into two groups: Group 1, control treated with placebo, and Group 2, treated daily with enoxaparin (2.5 mg/kg) for 50 days. All mice were subjected to necropsy and histological analysis. The results from gross and microscopic assessments showed no variation in the prevalence of lesions between the groups. An analysis was also performed among survivors and non-survivors, showing that animals that died often presented lesions, such as granulation tissue in the serosa, and intestinal infarction and adhesion. The mortality rate did not vary between the enoxaparin-treated and control groups. Thus, we showed that high doses of enoxaparin have no protective effect against AA, as the survival rates and lesions of mice did not vary between the treated and control groups. Considering that the use of prophylactic doses was also shown to be ineffective in a previous study, we do not recommend the use of enoxaparin for AA treatment.
General Alberto Enríquez Gallo: Soldier, Populist, Leftist
Authors: BECKER MARC 
Published: October 2017

AbstractA tradition in Latin America of reliance on strong leaders becomes problematic when political parties look outside their ranks for candidates who have popular appeal but do not embody their ideologies. This contradiction emerged in Ecuador in the mid-twentieth century when the Left looked to General Alberto Enríquez Gallo as its champion. His early trajectory in the military made him a most unlikely hero for the Left, but when he promulgated progressive labour legislation he gained its strong support. It was, however, a marriage of convenience, as leftists and populists inherently follow different political logics.
Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in Han Chinese women
Authors: Edwards A. C. , Docherty A. R. , Moscati A. , Bigdeli T. B. , Peterson R. E. , Webb B. T. , Bacanu S.-A. , Hettema J. M. , Flint J. , Kendler K. S. 
Published: October 2017

BackgroundPrevious studies have demonstrated that several major psychiatric disorders are influenced by shared genetic factors. This shared liability may influence clinical features of a given disorder (e.g. severity, age at onset). However, findings have largely been limited to European samples; little is known about the consistency of shared genetic liability across ethnicities.MethodThe relationship between polygenic risk for several major psychiatric diagnoses and major depressive disorder (MDD) was examined in a sample of unrelated Han Chinese women. Polygenic risk scores (PRSs) were generated using European discovery samples and tested in the China, Oxford, and VCU Experimental Research on Genetic Epidemiology [CONVERGE (maximumN= 10 502)], a sample ascertained for recurrent MDD. Genetic correlations between discovery phenotypes and MDD were also assessed. In addition, within-case characteristics were examined.ResultsEuropean-based polygenic risk for several major psychiatric disorder phenotypes was significantly associated with the MDD case status in CONVERGE. Risk for clinically significant indicators (neuroticism and subjective well-being) was also associated with case–control status. The variance accounted for by PRS for both psychopathology and for well-being was similar to estimates reported for within-ethnicity comparisons in European samples. However, European-based PRS were largely unassociated with CONVERGE family history, clinical characteristics, or comorbidity.ConclusionsThe shared genetic liability across severe forms of psychopathology is largely consistent across European and Han Chinese ethnicities, with little attenuation of genetic signal relative to within-ethnicity analyses. The overall absence of associations between PRS for other disorders and within-MDD variation suggests that clinical characteristics of MDD may arise due to contributions from ethnicity-specific factors and/or pathoplasticity.
Behaviour change techniques to facilitate physical activity in older adults: what and how
Authors: ARNAUTOVSKA URSKA , O'CALLAGHAN FRANCES , HAMILTON KYRA 
Published: October 2017

ABSTRACTPhysical inactivity in older adults presents a significant problem within modern societies globally. Using a mixed-method approach, this study explored strategies for the development and delivery of physical activity (PA) interventions by investigating what behaviour change techniques (BCTs) are useful, and how these techniques should be implemented to be feasible for older adults. Sixty-six older adults completed a survey indicating the most useful BCTs, mapping on to motivational, volitional and automatic factors. Of these, 48 older adults participated in an interview exploring strategies for a PA intervention targeted at older adults. The most useful BCT identified in the survey was autonomy support (61.3%), followed by instruction to perform the behaviour (43.5%) and having a credible source of information about PA (42.6%). The key themes discussed in the interviews included providing support in making an informed choice, instruction on how to perform PA, information about health consequences, social support, goal setting, action and coping plans, behavioural demonstration and practice, and monitoring PA. The interviews also revealed key aspects of programme implementation including face-to-face delivery, followed up with additional materials; low cost; age-appropriate PA level; and individualised approach. Interventions assisting older adults in increasing their PA participation across a range of settings should incorporate BCTs targeting multiple processes, while tailoring their delivery to older adults’ preferences to ensure their feasibility in supporting regular PA engagement.
‘Independence’ among older people receiving support at home: the meaning of daily care practices
Authors: BARKEN RACHEL 
Published: October 2017

ABSTRACTLater life care practices are closely entangled with the ideals of independence and dependence. Based on an interpretive analysis of qualitative interviews with 34 people aged 65–100 receiving home care in Ontario, Canada, this article explores older people's subjective interpretations of caring for themselves (i.e. independence) and receiving support from others (i.e. dependence). Findings suggest that individuals construct subjective meanings of independence in relation to their changing physical capacities, and in the context of their relationships with family members, friends and formal care providers. First, participants considered their care activities to be a way of maintaining independence when they undertook certain practices with the intention of staving off dependency and future decline. Second, when they accepted assistance, many engaged in care relations that allowed them to preserve an independent identity in the face of limits to physical self-sufficiency. Third, participants reached the limits of independence when they lacked adequate assistance, and were unable to care for themselves in desirable ways. Findings illustrate how objective circumstances related to social and financial resources as well as access to formal services shape subjective interpretations, allowing some older people to hold on to independent identities while exacerbating feelings of dependency among others.
Who Moved My Masterpiece? Digital Reproduction, Replacement, and the Vanishing Cultural Heritage of Kyoto
Authors: Yamada Shoji 
Published: October 2017

Abstract:In many temples in and around Kyoto, sets of wall and slide door paintings and folding screen paintings, which are designated either national treasures or important cultural properties of Japan, have been replaced in situ by high-quality digital reproductions. The original paintings, in turn, are now largely out of sight, placed in storage spaces within temples and museums. Vanguard projects of this nature were conducted in the mid-1990s. Since the mid-2000s, however, and without adequate review of the merits and demerits of such replacement, the practice has accelerated, and numerous sets of slide door paintings have been replaced by reproductions produced for the most part by two competing corporations. The process and implication of such digital replacement require far greater attention and discussion than has to date taken place. Accordingly, this article seeks to clarify the current status of, and problems arising from, the digitization projects taking place in and around Kyoto.
Agrarian Debt in Rural Switzerland: Economic Causes and Political Responses (1890–1940)
Authors: LORENZETTI LUIGI 
Published: October 2017

AbstractThe article seeks to determine the causes of the agrarian debt in rural Switzerland since the First World War and illustrate this growing phenomena in the 1920s and 1930s, by correlating the increase to the costs of the change in production beginning at the end of the nineteenth century, to the cut in the prices of agricultural products and the parallel depreciation of the soil after the war. After having outlined the effects of indebtedness reflected in the increase in the number of distraints, the article focuses on the political responses put in place to ensure the smooth running of mortgage loans – integrated since 1930 into a system of guarantees designed to limit the risks for creditors. The bill of the federal government intended to promote agricultural debt relief was long put off by some political circles, preferring to step in with precise measures, such as credit payments and extraordinary subsidies.
One For the (Farm) Workers? Perpetrator Risk and Victim Risk Transfer During the ‘Sevenoaks Fires’ of 1830
Authors: TAYLOR IAIN 
Published: October 2017

AbstractThe now extensive historiography of the ‘Captain Swing’ disturbances of 1830–1 contains two notable lacunae. Firstly, no thorough investigation has been undertaken of their first major episode, the ‘Sevenoaks Fires’ of summer 1830. Secondly, the overwhelming historiographical focus on Swing's perpetrators has ignored its victims almost entirely. This article therefore examines why particular farmers were singled out for incendiary attack in the area, what tactics they and the authorities employed in response and what that meant for social relations subsequently. The evidence reveals a trend towards greater accountability on the part of the elite and a growing confidence sometimes shown by the lower orders in challenging them. It does so, moreover, within an overarching framework of risk and risk transfer, since this provides an entirely new historiographical perspective on both the Fires and Swing generally. Finally, this approach is extended to suggest how it may have underpinned competing conceptions of Poor Law provision among the town's elite, post-Swing.
Vanishing Peregrines: J. A. Baker, Environmental Crisis and Bird-Centred Cultures of Nature, 1954–73
Authors: NIXON SEAN J. 
Published: October 2017

AbstractTaking J. A. Baker's celebrated bookThe Peregrineas its focus, the article seeks to locate Baker's writing within a broader, less elevated field of postwar observation and publication that worked to shape new ways of understanding, apprehending and taking pleasure from the natural environment. This included the recording practices and publications of the national and county naturalist and birdwatching societies that flourished in these years. The article shows how Baker's book was as much the product of this world of organised amateur natural history as it was of the world of high literature. Baker's book also sheds light on the reconfiguring of bird-human relations within competing postwar cultures of nature and the article uses it to explore the relationship between birdwatching and the bird-centred field sport of falconry. As organised birdwatching sought to establish moral authority over other bird-centred countryside pursuits in its understanding of natural relations, it cast field sports and other countryside practices as atavistic and archaic relics of older cultures of nature. Baker'sThe Peregrineallows us to see the convergences between the close attention to birds of prey and an intimacy with them that was shared by birdwatchers like Baker and falconers, even as Baker's narrative also sheds light on the differences between the two practices.
The Triangle of Empire:Sport, Religion, and Imperialism in Puerto Rico's YMCA, 1898–1926
Authors: Sotomayor Antonio 
Published: October 2017

In 1891, Luther H. Gulik, a prominent member of the international leadership of the YMCA of the United States, established the triangle as the YMCA symbol. He saw the triangle as a symbol imbued with Christian beliefs that would become the spearhead of a worldwide missionary movement. About the Triangle, Gulik wrote:The triangle stands . . . for the symmetrical man, each part developed with reference to the whole, and not merely with reference to itself. . . . What authority have we for believing that this triangle idea is correct? It is scriptural. . . . Such statements as, “Thou shalt love the Lord Thy God with all they heart and soul and mind and strength,” indicate . . . the scriptural view . . . that the service of the Lord includes the whole man. The words, which in the Hebrew and Greek are translated “strength,” refer in both cases entirely to physical strength.As the YMCA International Committee's first secretary for athletic work (1889–1902), Gulik had strong reason to create a symbol that could be recognized anywhere in the world. He was a firm believer in the expanding Muscular Christianity movement, which glorified patriotic duty and manliness expressed through athletics, and a strong believer in the civilizing agency of missionary Protestantism as it sought to establish a United States Christian righteous empire.
Contribution of zeolite-seeded experiments to the understanding of resumption of glass alteration
Authors: Fournier Maxime , Gin Stéphane , Frugier Pierre , Mercado-Depierre Sara 
Published: October 2017

AbstractUnderstanding the origin and the consequences of glass alteration regimes is necessary for the prediction of nuclear glass durability. The so-called “stage 3” or “resumption of alteration regime” of glasses used to sequester nuclear waste by vitrification, is characterized by a sudden acceleration of glass alteration rate arising from the precipitation of secondary minerals, mainly zeolites. To study this process, a promising approach is developed, based on seeding by synthesized zeolite seeds. This study quantitatively links the alteration of a six-oxide reference borosilicate glass (ISG) and the precipitation of zeolites that affects concentrations of key species—in particular aluminum—and thus the glass dissolution rate. The characterization of stage 3—easier at alkaline pH—can now be extended to pH conditions more representative of those found in a geological repository thanks to seeding that reduces, or even eliminates, the latency period preceding a resumption of glass alteration. The resumption occurrence and glass dissolution rate are related with temperature and pH. This study shows that the detrimental effect of zeolite precipitation decreases with decreasing pH and temperature, until it is no longer detectable at a pH around 9 imposed by the dissolution of the ISG glass. Even for both high temperature and high pH, the resumption rate is lower than the initial alteration rate, which remains the fastest kinetic regime.
Genetic and Epigenetic Profiling Reveals EZH2-mediated Down Regulation of OCT-4 Involves NR2F2 during Cardiac Differentiation of Human Embryonic Stem Cells
Authors: Pursani Varsha , Pethe Prasad , Bashir Mohsin , Sampath Prabha , Tanavde Vivek , Bhartiya Deepa 
Published: October 2017

AbstractHuman embryonic (hES) stem cells are widely used as an in vitro model to understand global genetic and epigenetic changes that occur during early embryonic development. In-house derived hES cells (KIND1) were subjected to directed differentiation into cardiovascular progenitors (D12) and beating cardiomyocytes (D20). Transcriptome profiling of undifferentiated (D0) and differentiated (D12 and 20) cells was undertaken by microarray analysis. ChIP and sequential ChIP were employed to study role of transcription factor NR2F2 during hES cells differentiation. Microarray profiling showed that an alteration of about 1400 and 1900 transcripts occurred on D12 and D20 respectively compared to D0 whereas only 19 genes were altered between D12 and D20. This was found associated with corresponding expression pattern of chromatin remodelers, histone modifiers, miRNAs and lncRNAs marking the formation of progenitors and cardiomyocytes on D12 and D20 respectively. ChIP sequencing and sequential ChIP revealed the binding of NR2F2 with polycomb group member EZH2 and pluripotent factor OCT4 indicating its crucial involvement in cardiac differentiation. The study provides a detailed insight into genetic and epigenetic changes associated with hES cells differentiation into cardiac cells and a role for NR2F2 is deciphered for the first time to down-regulate OCT-4 via EZH2 during cardiac differentiation.
Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice
Authors: Waider J , Popp S , Lange M D , Kern R , Kolter J F , Kobler J , Donner N C , Lowe K R , Malzbender J H , Brazell C J , Arnold M R , Aboagye B , Schmitt-Böhrer A , Lowry C A , Pape H C , Lesch K P 
Published: October 2017

AbstractMultiple lines of evidence implicate brain serotonin (5-hydroxytryptamine; 5-HT) system dysfunction in the pathophysiology of stressor-related and anxiety disorders. Here we investigate the influence of constitutively deficient 5-HT synthesis on stressor-related anxiety-like behaviors using Tryptophan hydroxylase 2 (Tph2) mutant mice. Functional assessment of c-Fos after associated foot shock, electrophysiological recordings of GABAergic synaptic transmission, differential expression of the Slc6a4 gene in serotonergic neurons were combined with locomotor and anxiety-like measurements in different contextual settings. Our findings indicate that constitutive Tph2 inactivation and consequential lack of 5-HT synthesis in Tph2 null mutant mice (Tph2−/−) results in increased freezing to associated foot shock and a differential c-Fos activity pattern in the basolateral complex of the amygdala. This is accompanied by altered GABAergic transmission as observed by recordings of inhibitory postsynaptic currents on principal neurons in the basolateral nucleus, which may explain increased fear associated with hyperlocomotion and escape-like responses in aversive inescapable contexts. In contrast, lifelong 5-HT deficiency as observed in Tph2 heterozygous mice (Tph+/−) is able to be compensated through reduced GABAergic transmission in the basolateral nucleus of the amygdala based on Slc6a4 mRNA upregulation in subdivisions of dorsal raphe neurons. This results in increased activity of the basolateral nucleus of the amygdala due to associated foot shock. In conclusion, our results reflect characteristic syndromal dimensions of panic disorder and agoraphobia. Thus, constitutive lack of 5-HT synthesis influence the risk for anxiety- and stressor-related disorders including panic disorder and comorbid agoraphobia through the absence of GABAergic-dependent compensatory mechanisms in the basolateral nucleus of the amygdala.
Pressurized Wideband Absorbance Findings in Healthy Neonates: A Preliminary Study
Authors: Wali Hamzah A. , Mazlan Rafidah , Kei Joseph 
Published: October 2017

Purpose
The present study aimed to establish normative data for wideband absorbance (WBA) measured at tympanometric peak pressure (TPP) and 0 daPa and to assess the test–retest reliability of both measurements in healthy neonates.

Method

Participants of this cross-sectional study included 99 full-term neonates (165 ears) with mean chronological age of 46.7 hrs (
SD
= 26.3 hrs). Of the 99 neonates, 58 were Malay, 28 were Indian, and 13 were Chinese. The neonates who passed high-frequency (1 kHz) tympanometry, acoustic stapedial reflex, and distortion product otoacoustic emission screening tests were assessed using a pressurized WBA test (wideband tympanometry). To reduce the number of measurement points, the WBA responses were averaged to 16 one-third octave frequency bands from 0.25 to 8 kHz. A mixed-model analysis of variance was applied to the data to investigate the effects of frequency, ear, gender, and ethnicity on WBA. The analysis of variance was also used to compare between WBA measured at TPP and 0 daPa. An interclass correlation coefficient test was applied at each of the 16 frequency bands to measure the test–retest reliability of WBA at TPP and 0 daPa.

Results
Both WBA measurements at TPP and 0 daPa exhibited a multipeaked pattern with 2 maxima at 1.25–1.6 kHz and 6.3 kHz and 2 minima at 0.5 and 4 kHz. The mean WBA measured at TPP was significantly higher than that measured at 0 daPa at 0.25, 0.4, 0.5, 1.25, and 1.6 kHz only. A normative data set was developed for absorbance at TPP and at 0 daPa. There was no significant effect of ethnicity, gender, and ear on both measurements of WBA. The test–retest reliability of WBA at TPP and 0 daPa was high with the interclass correlation coefficient ranging from 0.77 to 0.97 across the frequencies.

Conclusions
Normative data of WBA measured at TPP and 0 daPa for neonates were provided in the present study. Although WBA at TPP was slightly higher than the WBA measured at 0 daPa at some frequencies below 2 kHz, the WBA patterns of the 2 measurements were nearly identical. Moreover, the test–retest reliability of both WBA measurements was high.