bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduction of blood eosinophil counts in eosinophilic chronic rhinosinusitis after surgery
Authors: Honma A , Takagi D , Nakamaru Y , Homma A , Suzuki M , Fukuda S 
Published: November 2016

AbstractObjective:This study aimed to predict eosinophilic chronic rhinosinusitis prognosis by investigating changes in the blood eosinophil count and other disease biomarkers after surgery.Methods:Blood eosinophil numbers and serum interleukin-5 levels were measured in 22 eosinophilic chronic rhinosinusitis patients before and after functional endoscopic sinus surgery, and compared with equivalent measures in non-eosinophilic chronic rhinosinusitis patients and chronic rhinosinusitis without polyps patients. Differences between well-controlled eosinophilic chronic rhinosinusitis patients and those who experienced recurrence were also assessed.Results:Blood eosinophil numbers and serum interleukin-5 level decreased after surgery in eosinophilic chronic rhinosinusitis patients. In this patient group, blood eosinophil counts before surgery were significantly higher in patients who experienced recurrence (825.7 ± 26.1 vs 443.9 ± 76.6 cells/μl, p < 0.05), and decreased significantly after surgery (825.7 ± 26.1 vs 76.7 ± 25.8 cells/μl, p < 0.05).Conclusion:Blood eosinophil numbers may reflect disease severity in eosinophilic chronic rhinosinusitis patients and their prognosis after surgery.
Fragment-based approaches to TB drugs
Authors: MARCHETTI CHIARA , CHAN DANIEL S. H. , COYNE ANTHONY G. , ABELL CHRIS 
Published: November 2016

SUMMARYTuberculosis is an infectious disease associated with significant mortality and morbidity worldwide, particularly in developing countries. The rise of antibiotic resistance in Mycobacterium tuberculosis (Mtb) urgently demands the development of new drug leads to tackle resistant strains. Fragment-based methods have recently emerged at the forefront of pharmaceutical development as a means to generate more effective lead structures, via the identification of fragment molecules that form weak but high quality interactions with the target biomolecule and subsequent fragment optimization. This review highlights a number of novel inhibitors of Mtb targets that have been developed through fragment-based approaches in recent years.
An Intellectual Entertainment: Thought and Thinking
Authors: Hacker P. M. S. 
Published: November 2016

AbstractThis dialogue is on the nature of thought and thinking. The five disputants are Socrates, an imaginary neuroscientist from California (whose opinions reflect those of contemporary cognitive neuroscientists), an Oxford don from the 1950s (who employs the linguistic analytic techniques of his times), a Scottish post-doctoral student, and John Locke (who speaks for himself). The discussion takes place in Elysium in the late afternoon. They examine the idea that thinking is an activity of the mind or the brain, whether the medium of thought consists of words or ideas, whether thoughtful speech is speech accompanied by thought, whether thinking, i.e. reasoning and inferring, is a process, and what is meant by the claim that ‘thinking is the last interpretation’. The dialogue ends when the protagonists go to dinner, but will be resumed after the meal.
An Intellectual Entertainment: Thought and Language
Authors: Hacker P. M. S. 
Published: November 2016

AbstractThis dialogue on thought and language is a sequel to my dialogue ‘Thought and Thinking’, but can be read independently of it. The five disputants are the same as in the previous dialogue, namely Socrates; an imaginary neuroscientist from California (whose opinions reflect those of contemporary cognitive neuroscientists); an Oxford don from the 1950s (who employs the linguistic analytic techniques of his times); a Scottish post-doctoral student; and John Locke (who speaks for himself). The discussion takes place in Elysium in the early evening after dinner. They discuss the relationship between what one thinks and what one says, examine the reasons for supposing that there must be a language of thought and show why there cannot be one, investigate the supposition that thought must have a medium – that one must think in something (words, ideas, pre-linguistic concepts) – and demonstrate that it cannot have one. They investigate whether there can be non-linguistic thinking and whether non language-using animals can be said to think, and determine the limits of thought and thinking.
Novel three-dimensional optimal path planning method for vehicles with constrained pitch and yaw
Authors: Wehbe B. , Bazzi S. , Shammas E. 
Published: November 2016

SUMMARYThis paper presents a novel method for generating three-dimensional optimal trajectories for a vehicle or body that moves forward at a constant speed and steers in both horizontal and vertical directions. The vehicle's dynamics limit the body-frame pitch and yaw rates; additionally, the climb and decent angles of the vehicle are also bounded. Given the above constraints, the path planning problem is solved geometrically by building upon the two-dimensional Dubins curves and then Pontryagin's Maximum Principle is used to validate that the proposed solution lies within the family of candidate time-optimal trajectories. Finally, given the severe boundedness constraints on the vertical motion of the system, the robustness of the proposed path planning method is validated by naturally extending it to remain applicable to high-altitude final configurations.
Community structure of fern-affiliated endophytes in three neotropical forests
Authors: Del Olmo-Ruiz Mariana , Arnold A. Elizabeth 
Published: November 2016

Abstract:From the saprotrophs that decay plant material to the pathogens and mutualists that shape plant demography at local and regional scales, fungi are major drivers of tropical forest dynamics. Although endophytic fungi are abundant and diverse in many biomes, they reach their greatest diversity in tropical forests, where they can influence plant physiology, performance and survival. The number of quantitative studies regarding endophytes has increased dramatically in the past two decades, but general rules have not yet emerged regarding the biogeography, host affiliations, local or regional distributions, or phylogenetic diversity of endophytes in most tropical settings. Here, endophytic fungal communities associated with 18 species of eupolypod fern were compared among forest reserves in Panama, Costa Rica and Mexico. Molecular sequence data for >2000 isolates were used to determine the relationships of host taxonomy, forest (site), and environmental dissimilarity to endophyte community composition. Communities in related ferns differed significantly among forests, reflecting the interplay of geographic distance and environmental dissimilarity. Although the same phyla and classes of fungi were prevalent at each site, they differed in relative abundance. All sites were dominated by the same order (Xylariales), but sites differed in the phylogenetic clusteringvs.evenness of their endophyte communities. By addressing the relationship of endophyte communities to host taxonomy, geographic distance and environmental factors, this study complements previous work on angiosperms and contributes to a growing perspective on the factors shaping communities of ecologically important fungi in tropical forests.
Getting to Peace: Roger Fisher's Scholarship in International Law and the Social Sciences
Authors: MAMO ANDREW 
Published: November 2016

AbstractThis article examines Roger Fisher's scholarship in international law in the decades prior to the publication ofGetting to Yes. Fisher engaged with the same major questions as other international law scholars during the Cold War, but his scholarship was distinguished by the degree to which he grappled with the cutting-edge social science of the mid-century. Even as Fisher collaborated with game theorists and nuclear strategists to understand the theory of conflict, he maintained a critical view of the basic assumptions of game theoretic analysis – defending certain normative elements of the methodology even as he denied its descriptive claims. Subsequent work sought to generate robust descriptions of the role of law in international decision-making during crises. Fisher's normative and descriptive studies of the role of law in such crises led directly toGetting to Yes, creating a body of ‘meta-game theory’ that situated formal studies of conflict within a lawyer's understanding of dispute resolution. Fisher's engagement with social scientists helps illuminate current methodological debates in international law by highlighting the stakes of these theoretical questions and the tensions between scholarship and practice in international law.
Archaeologies of risk and wonder
Authors: Alberti Benjamin 
Published: November 2016

AbstractIn this statement, I argue that one way for archaeology to realize the potential of its materials to tell us something different about the past is to confront the question of alterity, understood as the ontological difference that lies at the roots of much archaeological material. If we accept alterity as a starting point of analysis then we stand a chance of challenging the strictures of interpretive frameworks that foreclose the possibility of encountering something new. Methodologically and theoretically I argue for risk-taking, especially taking on conceptual resources from indigenous thinkers and adopting a stance of wonder in the face of our materials which can open up unsuspected archaeological realities.
Tangled between paradigms in the neo-baroque era
Authors: Criado-Boado Felipe 
Published: November 2016

AbstractThe underlying notion for this article is that archaeology requires an amalgamation of humanities and science, and of narrative and scientific knowledge. The need for this fusion has arisen in a context in which contemporary society is experiencing major changes in epistemics, aesthetics and fashion; an increase in virtual experiences; and an economic crisis. I refer to this situation as the neo-baroque, a condition that is elusive and partially ambiguous. This social context (perhaps the final crisis of modernity), and the breakdown of this integration in pragmatic terms, call for a repoliticization of science.
To hell with ethnoarchaeology!
Authors: Gosselain Olivier P. 
Published: November 2016

AbstractThis paper is a charge against ethnoarchaeology. Deliberately provocative, it aims at highlighting the flaws and ideological pitfalls of a sub-discipline whose actual contribution to archaeology remains hardly decipherable. Beside a methodological deficiency and the frequent narrow-mindedness of the research agenda, ethnoarchaeology suffers from two major problems. First, it carries implicitly an old evolutionary – and racist – ideology that divides the world between modern Western societies (inappropriate for ethnoarchaeological research) and premodern exotic societies (well fitted for ethnoarchaeological research). Second, the quest for universal models of interpretation leads ethnoarchaeologists to play down historical contingency and cultural specificities, which not only deprive them of a good understanding of the ethnographical contexts, but also contribute to restricting ethnoarchaeological applications to a mere quest for similarities (or dissimilarities) in the material record. The problems are too profound to justify an umpteenth salvage of the sub-discipline. Rather, the proposition is to get rid of ethnoarchaeology once and for all, and join forces with other, more serious, disciplines.
Applications in Stimulated Emission Depletion Microscopy: Localization of a Protein Toxin in the Endoplasmic Reticulum Following Retrograde Transport
Authors: Herrera Cristina , Mantis Nicholas J. , Cole Richard 
Published: November 2016

AbstractRetrograde transport is a process in which proteins are trafficked from the plasma membrane and endosomes to biosynthetic and secretory organelles, namely the Golgi apparatus and endoplasmic reticulum (ER). A number of plant and bacterial toxins, including cholera toxin and ricin toxin, exploit retrograde transport to gain entry into host cells, although the specifics of this process have remained difficult to probe by laser scanning confocal microscopy (LSCM). Here we demonstrate the use of super-resolution and live-cell imaging [stimulated emission depletion (STED)] to visualize exogenously applied ricin toxin within the ER. The improved resolution obtained by STED, as compared with LSCM (0.09 versus 0.19μm), provides a more accurate determination of the amount of ricin that had trafficked to the ER.
Study of unflattened photon beams shaped by multileaf collimator using BEAMnrc code
Authors: kajaria Ankit , Sharma Neeraj , Sharma Shiru , Pradhan Satyajit , Mandal Abhijit , Aggarwal Lalit M. 
Published: November 2016

AbstractPurposeIn our study basic dosimetric properties of a flattening filter free 6 MV photon beam shaped by multileaf collimators (MLC) is examined using the Monte Carlo (MC) method.Methods and MaterialsBEAMnrc code was used to make a MC simulation model for 6 MV photon beam based on Varian Clinic 600 unique performance linac, operated with and without a flattening filter in beam line. Dosimetric features including central axis depth dose, beam profiles, photon and electron spectra were calculated and compared for flattened and unflattened cases.ResultsDosimetric field size and penumbra were found to be smaller for unflattened beam, and the decrease in field size was less for MLC shaped in comparison with jaw-shaped unflattened beam. Increase in dose rate of >2·4 times was observed for unflattened beam indicating a shorter beam delivery time for treatment. MLC leakage was found to decrease significantly when the flattening filter was removed from the beam line. The total scatter factor showed slower deviation with field sizes for unflattened beam indicating a reduced head scatter.ConclusionsOur study demonstrated that improved accelerator characteristics can be achieved by removing flattening filter from beam line.
Support for using five attributes to describe spirituality among families with a parent in hospice
Authors: Stephenson Pam Shockey , Sheehan Denice , Shahrour Ghada 
Published: November 2016

ABSTRACTObjective:The importance of spirituality in the dying process is well documented. However, what spirituality means in these situations is hard to discern because few people (patients, families, researchers, or caregivers) will view spirituality in the same way. The present research supports the use of a spiritual framework consisting of five common attributes (meaning, beliefs, connections, self-transcendence, and value) as a mechanism for viewing spirituality for people nearing the end of life. Using qualitative interviews from two related studies, our study aims to describe the prevalence of spirituality and its nature according to these five spiritual attributes.Methods:Data from two previous studies were analyzed. The first employed the methods of grounded theory to understand the strategies adolescents used to manage the impending death of a parent. Some 61 participants from 26 families were interviewed, including ill parents/patients, well parents/caregivers, and adolescents. The second study consisted of 15 interviews with the surviving parent and adolescents from 6 of these families after the death of the parent.Results:The original research from which these data were drawn did not seek to describe spirituality. However, spiritual themes were prevalent in the stories of many participants and included each of the five spiritual attributes.Significance of Results:Our findings demonstrate the prevalence of spirituality in the everyday lives of these families and supports the use of the spiritual framework according to the five common attributes to describe spirituality.
Stakeholder engagement in prioritizing sustainability assessment themes for smallholder coffee production in Uganda
Authors: Ssebunya Brian Robert , Schmid Erwin , van Asten Piet , Schader Christian , Altenbuchner Christine , Stolze Matthias 
Published: November 2016

AbstractMany sustainability assessment frameworks have been developed in recent years, but translating them into practical tools to guide decision making remains challenging. By engaging coffee stakeholders in Uganda, we demonstrate a process of translating the widely-accepted framework for Sustainability Assessments of Food and Agriculture Systems (SAFA), developed by the Food and Agriculture Organisation of the United Nations (FAO), to smallholder production systems. Stakeholders prioritized the sustainability themes in terms of relevance and feasibility, and subsequently identified relevant sub-themes. We find that the structure and scope of some generally accepted themes need appropriate modifications in order to address the social and structural heterogeneity of smallholder production systems. Although importance and feasibility rankings significantly vary within and between stakeholder groups, governance and economic themes are commonly perceived as very important though equally the least feasible for smallholders. Thus, the inclusion of the ‘farmer-group’ structure as part of the sustainability assessment criteria is perceived as necessary especially toward achieving governance-related goals. These findings emphasize the need of engaging stakeholders in defining locally adapted sustainability assessment criteria.
Erupted frothy xenoliths may explain lack of country-rock fragments in plutons
Authors: Burchardt Steffi , Troll Valentin R. , Schmeling Harro , Koyi Hemin , Blythe Lara 
Published: November 2016

AbstractMagmatic stoping is discussed to be a main mechanism of magma emplacement. As a consequence of stoping, abundant country-rock fragments should occur within and at the bottom of, magma reservoirs as “xenolith graveyards”, or become assimilated. However, the common absence of sufficient amounts of both xenoliths and crustal contamination have led to intense controversy about the efficiency of stoping. Here, we present new evidence that may explain the absence of abundant country-rock fragments in plutons. We report on vesiculated crustal xenoliths in volcanic rocks that experienced devolatilisation during heating and partial melting when entrained in magma. We hypothesise that the consequential inflation and density decrease of the xenoliths allowed them to rise and become erupted instead of being preserved in the plutonic record. Our thermomechanical simulations of this process demonstrate that early-stage xenolith sinking can be followed by the rise of a heated, partially-molten xenolith towards the top of the reservoir. There, remnants may disintegrate and mix with resident magma or erupt. Shallow-crustal plutons emplaced into hydrous country rocks may therefore not necessarily contain evidence of the true amount of magmatic stoping during their emplacement. Further studies are needed to quantify the importance of frothy xenolith in removing stoped material.
An open-hardware platform for optogenetics and photobiology
Authors: Gerhardt Karl P. , Olson Evan J. , Castillo-Hair Sebastian M. , Hartsough Lucas A. , Landry Brian P. , Ekness Felix , Yokoo Rayka , Gomez Eric J. , Ramakrishnan Prabha , Suh Junghae , Savage David F. , Tabor Jeffrey J. 
Published: November 2016

AbstractIn optogenetics, researchers use light and genetically encoded photoreceptors to control biological processes with unmatched precision. However, outside of neuroscience, the impact of optogenetics has been limited by a lack of user-friendly, flexible, accessible hardware. Here, we engineer the Light Plate Apparatus (LPA), a device that can deliver two independent 310 to 1550 nm light signals to each well of a 24-well plate with intensity control over three orders of magnitude and millisecond resolution. Signals are programmed using an intuitive web tool named Iris. All components can be purchased for under $400 and the device can be assembled and calibrated by a non-expert in one day. We use the LPA to precisely control gene expression from blue, green, and red light responsive optogenetic tools in bacteria, yeast, and mammalian cells and simplify the entrainment of cyanobacterial circadian rhythm. The LPA dramatically reduces the entry barrier to optogenetics and photobiology experiments.
Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells
Authors: Ohta Ryo , Niwa Akira , Taniguchi Yukimasa , Suzuki Naoya M. , Toga Junko , Yagi Emiko , Saiki Norikazu , Nishinaka-Arai Yoko , Okada Chihiro , Watanabe Akira , Nakahata Tatsutoshi , Sekiguchi Kiyotoshi , Saito Megumu K. 
Published: November 2016

AbstractObtaining highly purified differentiated cells via directed differentiation from human pluripotent stem cells (hPSCs) is an essential step for their clinical application. Among the various conditions that should be optimized, the precise role and contribution of the extracellular matrix (ECM) during differentiation are relatively unclear. Here, using a short fragment of laminin 411 (LM411-E8), an ECM predominantly expressed in the vascular endothelial basement membrane, we demonstrate that the directed switching of defined ECMs robustly yields highly-purified (>95%) endothelial progenitor cells (PSC-EPCs) without cell sorting from hPSCs in an integrin-laminin axis-dependent manner. Single-cell RNA-seq analysis revealed that LM411-E8 resolved intercellular transcriptional heterogeneity and escorted the progenitor cells to the appropriate differentiation pathway. The PSC-EPCs gave rise to functional endothelial cells both in vivo and in vitro. We therefore propose that sequential switching of defined matrices is an important concept for guiding cells towards desired fate.
Neoadjuvant chemotherapy for Patients with advanced epithelial ovarian cancer: A Meta-Analysis
Authors: Zeng Long-Jia , Xiang Chun-Lin , Gong Yi-Zhen , Kuang Yan , Lu Fang-Fang , Yi Su-Yi , Zhang Yue , Liao Meng 
Published: November 2016

AbstractThe value of neoadjuvant chemotherapy (NAC) has not yet been fully defined. We aimed to systematically evaluate the influence of neoadjuvant chemotherapy (NAC) on survival and complete cytoreduction after debulking surgery in advanced epithelial ovarian cancer (AEOC) patients. We searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials for the randomized controlled trials (RCTs) comparing NAC and primary debulking surgery (PDS) in AEOC patients. The last search date is February 25, 2016. Cochrane systematic evaluation was used to evaluate bias risk of included studies. RevMan 5.3 software was used for statistical analysis. A total of 4 RCTs involving 1922 patients were included. Compared with PDS, NAC may contribute to the completeness of debulking removal [no residual disease (RR: 2.37; 95%CI: 1.94–2.91; P<0.00001), residual disease ≤1 cm (RR: 1.28; 95%CI: 1.04–1.57; P = 0.02), optimal cytoreduction rate (RR: 1.76; 95%CI: 1.57–1.98; P<0.00001)], but there were no significant differences in both groups with regard to overall survival (HR: 0.94; 95%Cl: 0.81–1.08; P = 0.38) and progression-free survival (HR: 0.89; 95%Cl: 0.77–1.03; P = 0.12). This meta-analysis indicates that the higher rate of optimal debulking made NAC more favorable as a treatment option for AEOC patients with non-inferior survival compared with PDS.