bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Helix Angle on Hydrogen Diffusion of Spiral Weld
Pipe
Authors: Jiang Wenchun , Luo Yun , Zhang Xiaolei , Zhang Qian , Zhang W. Y. 
Published: July 2017

Abstract
This paper presents a study of hydrogen diffusion for a spiral weld pipe considering the effect of weld residual stress. The results show that the hydrogen mainly gathers at heat-affected zone (HAZ). HAZ is the weakest zone where hydrogen-induced cracking (HIC) occurs. The effect of helix angle on the hydrogen diffusion is also discussed. It shows that different helix angles generate different hydrogen concentrations. As the helix angle increases, both the hydrogen concentration and residual stresses decrease. As the helix angle increases from 40 deg to 50 deg, the equivalent pressure stresses reduce a little, resulting in the change of hydrogen concentration being small. The smaller the helix angle is, the larger the diffusion rate is. The most suitable helix angle should be optimized at 40–50 deg.
Complete Genome Sequence of
Bradyrhizobium
sp. ORS285, a Photosynthetic Strain Able To Establish Nod Factor-Dependent or Nod Factor-Independent Symbiosis with
Aeschynomene
Legumes
Authors: Gully Djamel , Teulet Albin , Busset Nicolas , Nouwen Nico , Fardoux Joël , Rouy Zoe , Vallenet David , Cruveiller Stéphane , Giraud Eric 
Published: July 2017

ABSTRACT

Here, we report the complete genome sequence of
Bradyrhizobium
sp. strain ORS285, which is able to nodulate
Aeschynomene
legumes using two distinct strategies that differ in the requirement of Nod factors. The genome sequence information of this strain will help understanding of the different mechanisms of interaction of rhizobia with legumes.
Identification of Dezidougou Virus in a DAK AR 41524 Zika Virus Stock
Authors: Shrivastava Susmita , Puri Vinita , Fedorova Nadia , Amedeo Paolo , Stockwell Timothy B. , Shabman Reed S. , Rashid Sujatha , Pickett Brett E. 
Published: July 2017

ABSTRACT
We report here the complete genome of a Dezidougou virus (DEZV) isolated from a passaged culture of the Zika virus strain DAK AR 41524. The consensus DEZV sequence we recovered shows 99% nucleotide similarity using BLASTN to a previously reported DEZV (accession no. JQ675604.1). The current sequence has additional repeat regions as well as a deleted repeat region, which we confirmed by Sanger sequencing, that were not present in the originally published sequence, JQ675604.1.
Complete Genome Sequence of Kluyveromyces lactis Strain GG799, a Common Yeast Host for Heterologous Protein Expression
Authors: Chuzel Léa , Ganatra Mehul B. , Schermerhorn Kelly M. , Gardner Andrew F. , Anton Brian P. , Taron Christopher H. 
Published: July 2017

ABSTRACT

We report the genome sequence of the dairy yeast
Kluyveromyces lactis
strain GG799 obtained using the Pacific Biosciences RS II platform.
K. lactis
strain GG799 is a common host for the expression of proteins at both laboratory and industrial scales.
Draft Genome Sequence of Terrimicrobium sacchariphilum NM-5
T
, a Facultative Anaerobic Soil Bacterium of the Class
Spartobacteria
Authors: Qiu Yan-Ling , Tourlousse Dieter M. , Matsuura Norihisa , Ohashi Akiko , Sekiguchi Yuji 
Published: July 2017

ABSTRACT

We report here a high-quality draft genome sequence of
Terrimicrobium sacchariphilum
strain NM-5
T
, a facultative anaerobic, mesophilic, fermentative bacterium belonging to the class
Spartobacteria
of the phylum
Verrucomicrobia
. The genome comprises 4,751,807 bp in three contigs and has a G+C content of 60.19%. Annotation predicted 4,175 protein-coding sequences and 54 RNAs.
Novel RNA Virus Genome Discovered in Ghost Ants (
Tapinoma melanocephalum
) from Hawaii
Authors: Brettell Laura E. , Mordecai Gideon J. , Pachori Purnima , Martin Stephen J. 
Published: July 2017

ABSTRACT

Here, we report the full-genome sequence of Milolii virus, a novel single-stranded (positive-sense) RNA virus discovered from
Tapinoma melanocephalum
ants in Hawaii. The genome is 10,475 nucleotides long, encoding a polyprotein of 3,304 amino acids.
Whole-Genome Shotgun Sequences of Salmonella enterica Serovar Typhimurium Lilleengen Type Strains LT1, LT18, LT19, LT20, LT21, and LT22
Authors: Kazmierczak Robert A. , Best Aaron A. , Nguyen Duy , Eisenstark Abraham 
Published: July 2017

ABSTRACT

The Lilleengen type (LT) collection of
Salmonella enterica
serovar Typhimurium strains has served the scientific community as a group of model organisms for basic genetic and biochemical pathway research. Here, we report the whole-genome shotgun sequences of
Salmonella enterica
serovar Typhimurium strains LT1, LT18, LT19, LT20, LT21, and LT22.
Draft Genome Sequences of
Saccharibacter
sp. Strains 3.A.1 and M18 Isolated from Honey and a Honey Bee (Apis mellifera) Stomach
Authors: Veress Alexandra , Wilk Tímea , Kiss János , Olasz Ferenc , Papp Péter P. 
Published: July 2017

ABSTRACT

The annotated draft genome sequences of two recent
Saccharibacter
sp. strains isolated from honey and a honey bee stomach in 2014 are reported here. Currently, two
Saccharibacter
whole-genome sequences are available in databases; thus, the sequences of our new isolates will contribute to a better understanding of
Saccharibacter
genomes.
Fungal Recognition and Host Defense Mechanisms
Authors: Dambuza I. M. , Levitz S. M. , Netea M. G. , Brown G. D. 
Published: July 2017

ABSTRACT
Fungi have emerged as premier opportunistic microbes of the 21st century, having a considerable impact on human morbidity and mortality. The huge increase in incidence of these diseases is largely due to the HIV pandemic and use of immunosuppressive therapies, underscoring the importance of the immune system in defense against fungi. This article will address how the mammalian immune system recognizes and mounts a defense against medically relevant fungal species.
Regulatory Issues Associated with Preharvest Food Safety: United States Perspective
Authors: Micallef Shirley A. , Buchanan Robert L. 
Published: July 2017

ABSTRACTThe preharvest and preslaughter steps of food production constitute a first stage at which food can become contaminated with foodborne and toxigenic pathogens. Contamination at this early stage of food production can lead to amplification as food travels through the production and supply chain, accentuating the crucial need to address hazards and establish science-based metrics that are feasible to implement. This article discusses the preharvest food safety regulatory landscape in the United States, with a specific emphasis on fresh produce crops. Best practices, certification, audit schemes and challenges due to market channels, economies of scales, and grower behavior are considered in relation to the Food Safety Modernization Act. An outlook on the needs to facilitate implementation of the new law, develop educational programs for growers and stakeholders, and continue to better align food safety with environmental goals are presented.
Associations of anthropometry since birth with sagittal posture at age 7 in a prospective birth cohort: the Generation XXI Study
Authors: Araújo Fábio A , Lucas Raquel , Simpkin Andrew J , Heron Jon , Alegrete Nuno , Tilling Kate , Howe Laura D , Barros Henrique 
Published: July 2017

ObjectivesAdult sagittal posture is established during childhood and adolescence. A flattened or hypercurved spine is associated with poorer musculoskeletal health in adulthood. Although anthropometry from birth onwards is expected to be a key influence on sagittal posture design, this has never been assessed during childhood. Our aim was to estimate the association between body size throughout childhood with sagittal postural patterns at age 7.DesignProspective cohort study.Setting and participantsA subsample of 1029 girls and 1101 boys taking part in the 7-year-old follow-up of the birth cohort Generation XXI (Porto, Portugal) was included. We assessed the associations between anthropometric measurements (weight, height and body mass index) at birth, 4 and 7 years of age and postural patterns at age 7. Postural patterns were defined using latent profile analysis, a probabilistic model-based technique which allows for simultaneously including anthropometrics as predictors of latent profiles by means of logistic regression.ResultsPostural patterns identified were sway, flat and "neutral to hyperlordotic"in girls, and "sway to neutral", flat and hyperlordotic in boys; with flat and hyperlordotic postures representing a straightened and a rounded spine, respectively. In both girls and boys, higher weight was associated with lower odds of a flat pattern compared with a sway/"sway to neutral"pattern, with stronger associations at older ages: for example, ORs were 0.68 (95% CI 0.53 to 0.88) per SD increase in birth weight and 0.36 (95% CI 0.19 to 0.68) per SD increase in weight at age 7 in girls, with similar findings in boys. Boys with higher ponderal index at birth were more frequently assigned to the hyperlordotic pattern (OR=1.44 per SD; p=0.043).ConclusionsOur findings support a prospective sculpting role of body size and therefore of load on musculoskeletal spinopelvic structures, with stronger associations as children get older.
Medication incidents in primary care medicine: a prospective study in the Swiss Sentinel Surveillance Network (Sentinella)
Authors: Gnädinger Markus , Conen Dieter , Herzig Lilli , Puhan Milo A , Staehelin Alfred , Zoller Marco , Ceschi Alessandro 
Published: July 2017

ObjectivesTo describe the type, frequency, seasonal and regional distribution of medication incidents in primary care in Switzerland and to elucidate possible risk factors for medication incidents.DesignProspective surveillance study.SettingSwiss primary healthcare, Swiss Sentinel Surveillance Network.ParticipantsPatients with drug treatment who experienced anyerroneousevent related to the medication process and interfering with normal treatment course, as judged by their physician. The 180 physicians in the study were general practitioners or paediatricians participating in the Swiss Federal Sentinel reporting system in 2015.OutcomesPrimary:medication incidents;secondary:potential risk factors like age, gender, polymedication, morbidity, care-dependency, previous hospitalisation.ResultsThe mean rates of detected medication incidents were 2.07 per general practitioner per year (46.5 per 1 00 000 contacts) and 0.15 per paediatrician per year (2.8 per 1 00 000 contacts), respectively. The following factors were associated with medication incidents (OR, 95% CI): higher age 1.004 per year (1.001; 1.006), care by community nurse 1.458 (1.025; 2.073) and care by an institution 1.802 (1.399; 2.323), chronic conditions 1.052 (1.029; 1.075) per condition, medications 1.052 (1.030; 1.074) per medication, as well as Thurgau Morbidity Index for stage 4: 1.292 (1.004; 1.662), stage 5: 1.420 (1.078; 1.868) and stage 6: 1.680 (1.178; 2.396), respectively. Most cases were linked to an incorrect dosage for a given patient, while prescription of an erroneous medication was the second most common error.ConclusionsMedication incidents are common in adult primary care, whereas they rarely occur in paediatrics. Older and multimorbid patients are at a particularly high risk for medication incidents. Reasons for medication incidents are diverse but often seem to be linked to communication problems.
Ability to join the workforce and work productivity among drug users under methadone maintenance treatment in a mountainous area of Northern Vietnam: a cross-sectional study
Authors: Nong Vuong Minh , Boggiano Victoria L , Nguyen Lan Huong Thi , Nguyen Cuong Tat , Nguyen Long Hoang , Xuan Bach Tran , Nguyen Hung Van , Hoang Canh Dinh , Latkin Carl A , Vu Minh Thuc Thi 
Published: July 2017

ObjectivesA major measure of treatment success for drug users undergoing rehabilitation is the ability to enter the workforce and generate income. This study examines the absenteeism and productivity among people who inject drugs (PWID) enrolled in methadone maintenance treatment (MMT) in Northern Vietnam.SettingWe conducted a cross-sectional study in two clinics in Tuyen Quang province.ParticipantsA total of 241 patients enrolled in MMT.Primary and secondary outcome measuresPatients’ work productivity was measured using the WPAI-GH instrument (Work Productivity and Activity Impairment Questionnaire: General Health V2.0). We also collected additional characteristics about participants’ employment history, such as proficient jobs, whether they actively found a new job and be accepted by employers.ResultsMost of the participants (>90%) were employed at the time of the study. Rates of absenteeism (missed work), presenteeism (impairment while working) and overall loss of productivity were 15.8%, 5.6% and 11.2%, respectively, as measured by the WPAI-GH questionnaire. The most proficient job was ‘freelancer’ (17.5%), followed by ‘blue-collar worker’ (10.6%) and ‘farmer’ (10.2%). Only 26.8% of patients reported that they actively sought jobs in the past. About half of them had been refused by employers because of their drug use history and/or HIV status. We found no statistically significant difference between patients enrolled in MMT for <1 year and those who had been enrolled >1 year. Factors associated with higher work productivity included not endorsing problems in mobility, self-care or pain; being HIV-negative and having greater MMT treatment adherence.ConclusionOur study highlights the high employment rate and work productivity among PWID in MMT programmes in remote areas of Northern Vietnam. The results can help to improve the quality and structure of MMT programmes across Vietnam and in other countries.
Recent advances in the treatment of erectile dysfunction
Authors: Mobley David F , Khera Mohit , Baum Neil 
Published: July 2017

ABSTRACTErectile dysfunction (ED) is one of the most common conditions affecting middle-aged and older men. Nearly every primary care physician, internist and geriatrician will be called upon to manage this condition or to make referrals to urologists, endocrinologists and cardiologists who will assist in the treatment of ED. This article will briefly discuss the diagnosis and management of ED. In addition, emerging concepts in ED management will be discussed, such as the use of testosterone to treat ED, the role of the endothelium in men with ED and treating the partner of the man with ED. Finally, future potential therapies for ED will be discussed.
Enhanced recovery after surgery for hip and knee arthroplasty: a systematic review and meta-analysis
Authors: Zhu Shibai , Qian Wenwei , Jiang Chao , Ye Canhua , Chen Xi 
Published: July 2017

ABSTRACTObjectivesTo collect data of randomised controlled trials (RCTs) and clinical controlled trials (CCTs) for evaluating the effects of enhanced recovery after surgery on postoperative recovery of patients who received total hip arthroplasty (THA) or total knee arthroplasty (TKA).MethodsRelevant, published studies were identified using the following key words: arthroplasty, joint replacement, enhanced recovery after surgery, fast track surgery, multi-mode analgesia, diet management, or steroid hormones. The following databases were used to identify the literature consisting of RCTs or CCTs with a date of search of 31 December 2016: PubMed, Cochrane, Web of knowledge, Ovid SpringerLink and EMBASE. All relevant data were collected from studies meeting the inclusion criteria. The outcome variables were postoperative length of stay (LOS), 30-day readmission rate, and total incidence of complications. RevMan5.2. software was adopted for the meta-analysis.ResultsA total of 10 published studies (9936 cases) met the inclusion criteria. The cumulative data included 4205 cases receiving enhanced recovery after surgery (ERAS), and 5731 cases receiving traditional recovery after surgery (non-ERAS). The meta-analysis showed that LOS was significantly lower in the ERAS group than in the control group (non-ERAS group) (p&lt;0.01), and there were fewer incidences of complications in the ERAS group than in the control group (p=0.03). However, no significant difference was found in the 30-day readmission rate (p=0.18).ConclusionsERAS significantly reduces LOS and incidence of complications in patients who have had THA or TKA. However, ERAS does not appear to significantly impact 30-day readmission rates.
New simple algorithms for computing the minimal polynomial of cos(2π/n)
Authors: Bouazizi Faïçal , Guetif Zaineb , Hidouri Sami 
Published: July 2017

The editor in chief was alerted to the fact that part of the paper was from M. F. Bouazizi's former PhD supervisor Annick Valibouze, as testified by the registration of the original paper on October 3, 2006 on the university platform: http://www.lsta.upmc.fr/prepublications R2006_5.pdf. This article was therefore, retracted from its publication in DMAA.
Recent Trends in Ovarian Cancer Incidence and Relative Survival in the United States by Race/Ethnicity and Histologic Subtypes
Authors: Park Hyo K. , Ruterbusch Julie J. , Cote Michele L. 
Published: July 2017

Abstract
Background: Incidence and survival rates of nonserous epithelial ovarian cancer in racial/ethnic minorities remain relatively unknown in the United States. We examined the trends in incidence and survival rates for epithelial ovarian cancer by histologic subtypes and race/ethnicity.
Methods: Ovarian cancer incidence and mortality data from 2000 to 2013 were obtained from the Surveillance, Epidemiology, and End Results database. Age-adjusted incidence rate, incidence rate ratio, and annual percentage changes (APC) were calculated by histology and race/ethnicity subgroups and stratified by age at diagnosis. Five-year relative survival rates were calculated by stage and race/ethnicity.
Results: A small but significant decrease in incidence rates was seen in non-Hispanic white (NHW), non-Hispanic black (NHB), and Hispanic women (APC −1.58, −0.84, and −1.31, respectively), while incidence rates remained relatively stable in Asian women (APC −0.37). With exception of significant increase in the incidence rate of clear cell carcinoma among Asian woman (APC 1.85), an overall trend toward decreasing incidence rates was seen across histologic subtypes and age-strata, although not all results were statistically significant. Compared with NHW women, NHB women experienced poorer 5-year survival at every stage across histologic subtypes, while Hispanic and Asian women had equivalent or better survival.
Conclusions: Over the last decade, incidence rates of epithelial ovarian cancer in the United States have decreased or remained stable across race/ethnic and histologic subgroups, except for clear cell carcinoma. Survival remains poorest among NHB women.
Impact: Comparative histologic subtype distribution and incidence trends do not explain the ovarian cancer survival disparity disproportionately affecting NHB women. Cancer Epidemiol Biomarkers Prev; 26(10); 1511–8. ©2017 AACR.
131I-labeled Anti-HER2 Camelid sdAb as a Theranostic Tool in Cancer Treatment
Authors: D'Huyvetter Matthias , De Vos Jens , Xavier Catarina , Pruszynski Marek , Sterckx Yann G.J. , Massa Sam , Raes Geert , Caveliers Vicky , Zalutsky Michael R. , Lahoutte Tony , Devoogdt Nick 
Published: July 2017

AbstractPurpose: Camelid single-domain antibody-fragments (sdAb) have beneficial pharmacokinetic properties, and those targeted to HER2 can be used for imaging of HER2-overexpressing cancer. Labeled with a therapeutic radionuclide, they may be used for HER2-targeted therapy. Here, we describe the generation of a 131I-labeled sdAb as a theranostic drug to treat HER2-overexpressing cancer.Experimental Design: Anti-HER2 sdAb 2Rs15d was labeled with 131I using [131I]SGMIB and evaluated in vitro. Biodistribution was evaluated in two HER2+ murine xenograft models by micro-SPECT/CT imaging and at necropsy, and under challenge with trastuzumab and pertuzumab. The therapeutic potential of [131I]SGMIB-2Rs15d was investigated in two HER2+ tumor mouse models. A single-dose toxicity study was performed in mice using unlabeled [127I]SGMIB-sdAb at 1.4 mg/kg. The structure of the 2Rs15d–HER2 complex was determined by X-ray crystallography.Results: [131I]SGMIB-2Rs15d bound specifically to HER2+ cells (Kd = 4.74 ± 0.39 nmol/L). High and specific tumor uptake was observed in both BT474/M1 and SKOV-3 tumor xenografted mice and surpassed kidney levels by 3 hours. Extremely low uptake values were observed in other normal tissues at all time points. The crystal structure revealed that 2Rs15d recognizes HER2 Domain 1, consistent with the lack of competition with trastuzumab and pertuzumab observed in vivo. [131I]SGMIB-2Rs15d alone, or in combination with trastuzumab, extended median survival significantly. No toxicity was observed after injecting [127I]SGMIB-2Rs15d.Conclusions: These findings demonstrate the theranostic potential of [131I]SGMIB-2Rs15d. An initial scan using low radioactive [*I]SGMIB-2Rs15d allows patient selection and dosimetry calculations for subsequent therapeutic [131I]SGMIB-2Rs15d and could thereby impact therapy outcome on HER2+ breast cancer patients. Clin Cancer Res; 23(21); 6616–28. ©2017 AACR.
Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER+ Breast Cancer
Authors: Formisano Luigi , Stauffer Kimberly M. , Young Christian D. , Bhola Neil E. , Guerrero-Zotano Angel L. , Jansen Valerie M. , Estrada Mónica M. , Hutchinson Katherine E. , Giltnane Jennifer M. , Schwarz Luis J. , Lu Yao , Balko Justin M. , Deas Olivier , Cairo Stefano , Judde Jean-Gabriel , Mayer Ingrid A. , Sanders Melinda , Dugger Teresa C. , Bianco Roberto , Stricker Thomas , Arteaga Carlos L. 
Published: July 2017

AbstractPurpose: FGFR1 amplification occurs in approximately 15% of estrogen receptor–positive (ER+) human breast cancers. We investigated mechanisms by which FGFR1 amplification confers antiestrogen resistance to ER+ breast cancer.Experimental Design: ER+ tumors from patients treated with letrozole before surgery were subjected to Ki67 IHC, FGFR1 FISH, and RNA sequencing (RNA-seq). ER+/FGFR1–amplified breast cancer cells, and patient-derived xenografts (PDX) were treated with FGFR1 siRNA or the FGFR tyrosine kinase inhibitor lucitanib. Endpoints were cell/xenograft growth, FGFR1/ERα association by coimmunoprecipitation and proximity ligation, ER genomic activity by ChIP sequencing, and gene expression by RT-PCR.Results: ER+/FGFR1–amplified tumors in patients treated with letrozole maintained cell proliferation (Ki67). Estrogen deprivation increased total and nuclear FGFR1 and FGF ligands expression in ER+/FGFR1–amplified primary tumors and breast cancer cells. In estrogen-free conditions, FGFR1 associated with ERα in tumor cell nuclei and regulated the transcription of ER-dependent genes. This association was inhibited by a kinase-dead FGFR1 mutant and by treatment with lucitanib. ChIP-seq analysis of estrogen-deprived ER+/FGFR1–amplified cells showed binding of FGFR1 and ERα to DNA. Treatment with fulvestrant and/or lucitanib reduced FGFR1 and ERα binding to DNA. RNA-seq data from FGFR1-amplified patients' tumors treated with letrozole showed enrichment of estrogen response and E2F target genes. Finally, growth of ER+/FGFR1–amplified cells and PDXs was more potently inhibited by fulvestrant and lucitanib combined than each drug alone.Conclusions: These data suggest the ERα pathway remains active in estrogen-deprived ER+/FGFR1–amplified breast cancers. Therefore, these tumors are endocrine resistant and should be candidates for treatment with combinations of ER and FGFR antagonists. Clin Cancer Res; 23(20); 6138–50. ©2017 AACR.