bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRIVATE ISSUES IN PESAT IN LATE COLONIAL JAVA
Authors: Amini Mutiah 
Published: March 2016

<p>Pesat was a local newspaper in Semarang published in the 1940s during the late colonial era. The establishment of Pesat could not be separated from the couple of I.M. Sajoeti and S.K. Trimurti, the owners of the newspaper, who were best-known as activitists of Political Party and senior journalists in Semarang at that time. As a local newspaper, the content of this publication differed considerably from the other local newspaper which mostly focused on news and advertisements. Pesat continuously published some information that had not been addressed by the media anywhere before. Pesat published transparently on the problems of family life and household. In particular, Pesat pointed the problems of marriage which placed women in domestic area in which they were not permitted to speak about the problems they were facing to other people in the public domain. This meant that a matter concerning the life of household which was previously considered private space was now published as news available to newspaper readers.</p> <p>Keywords: Pesat, private, colonial, Semarang, Java.</p> <p>Â </p> <p>Pesat adalah sebuah koran lokal di Semarang yang diterbitkan pada 1940-an selama era kolonial akhir. Pembentukan Pesat tak lepas dari pasangan IM Sajoeti dan SK Trimurti, pemilik surat kabar, yang dikenal sebagai aktifis Partai Politik dan wartawan senior di Semarang pada waktu itu. Sebagai koran lokal, isi dari publikasi ini berbeda jauh dari koran lokal lainnya yang berfokus pada berita dan iklan. Pesat terus menerbitkan beberapa informasi yang belum ditangani oleh media manapun sebelumnya. Dalam publikasi mereka, Pesat dipublikasikan secara transparan pada kehidupan masalah keluarga dalam rumah tangga. Secara khusus, diangkat masalah seputar pernikahan yang menempatkan perempuan dalam ruang domestik dan perempuan tidak diperbolehkan untuk berbicara tentang masalah yang mereka hadapi kepada orang lain dalam domain publik. Ini berarti bahwa masalah yang berkenaan dengan kehidupan rumah tangga yang sebelumnya dianggap ruang pribadi yang ada di luar keluarga diizinkan untuk tahu tentang itu sekarang telah diterbitkan sebagai berita tersedia bagi pembaca surat kabar.</p> <p>Kata kunci: Pesat, pribadi, kolonial, Semarang, Jawa.</p> <p>Â </p>
Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3–36
Authors: Iepsen Eva W , Lundgren Julie , Holst Jens J , Madsbad Sten , Torekov Signe S 
Published: March 2016

ObjectiveThe hormones glucagon-like peptide 1 (GLP-1), peptide YY3-36(PYY3–36), ghrelin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon have all been implicated in the pathogenesis of obesity. However, it is unknown whether they exhibit adaptive changes with respect to postprandial secretion to a sustained weight loss.DesignThe study was designed as a longitudinal prospective intervention study with data obtained at baseline, after 8 weeks of weight loss and 1 year after weight loss.MethodsTwenty healthy obese individuals obtained a 13% weight loss by adhering to an 8-week very low-calorie diet (800kcal/day). After weight loss, participants entered a 52-week weight maintenance protocol. Plasma levels of GLP-1, PYY3–36, ghrelin, GIP and glucagon during a 600-kcal meal were measured before weight loss, after weight loss and after 1 year of weight maintenance. Area under the curve (AUC) was calculated as total AUC (tAUC) and incremental AUC (iAUC).ResultsWeight loss was successfully maintained for 52 weeks. iAUC for GLP-1 increased by 44% after weight loss (P<0.04) and increased to 72% at week 52 (P=0.0001). iAUC for PYY3–36increased by 74% after weight loss (P<0.0001) and by 36% at week 52 (P=0.02). tAUC for ghrelin increased by 23% after weight loss (P<0.0001), but at week 52, the increase was reduced to 16% compared with before weight loss (P=0.005). iAUC for GIP increased by 36% after weight loss (P=0.001), but returned to before weight loss levels at week 52. Glucagon levels were unaffected by weight loss.ConclusionsMeal responses of GLP-1 and PYY3–36remained increased 1 year after weight maintenance, whereas ghrelin and GIP reverted toward before-weight loss values. Thus, an increase in appetite inhibitory mechanisms and a partly decrease in appetite-stimulating mechanisms appear to contribute to successful long-term weight loss maintenance.
Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase
Authors: Wang Zhenghan , Tacchelly-Benites Ofelia , Yang Eungi , Thorne Curtis A , Nojima Hisashi , Lee Ethan , Ahmed Yashi 
Published: March 2016

Abstract
Wnt/β-catenin signal transduction directs metazoan development and is deregulated in numerous human congenital disorders and cancers. In the absence of Wnt stimulation, a multiprotein “destruction complex,” assembled by the scaffold protein Axin, targets the key transcriptional activator β-catenin for proteolysis. Axin is maintained at very low levels that limit destruction complex activity, a property that is currently being exploited in the development of novel therapeutics for Wnt-driven cancers. Here, we use an in vivo approach in Drosophila to determine how tightly basal Axin levels must be controlled for Wnt/Wingless pathway activation, and how Axin stability is regulated. We find that for nearly all Wingless-driven developmental processes, a three- to fourfold increase in Axin is insufficient to inhibit signaling, setting a lower-limit for the threshold level of Axin in the majority of in vivo contexts. Further, we find that both the tumor suppressor adenomatous polyposis coli (APC) and the ADP-ribose polymerase Tankyrase (Tnks) have evolutionarily conserved roles in maintaining basal Axin levels below this in vivo threshold, and we define separable domains in Axin that are important for APC- or Tnks-dependent destabilization. Together, these findings reveal that both APC and Tnks maintain basal Axin levels below a critical in vivo threshold to promote robust pathway activation following Wnt stimulation.
Where to Turn for Second-Line Cytoreduction After Hydroxyurea in Polycythemia Vera?
Authors: Nazha Aziz , Gerds Aaron T. 
Published: March 2016

Abstract
The goals of therapy in patients with polycythemia vera (PV) are to improve disease-related symptoms, prevent the incidence or recurrence of thrombosis, and possibly delay or prevent the transformation into myelofibrosis or acute myeloid leukemia (AML). Cytoreductive therapies have been used in older patients and those with a history of thrombosis to achieve these goals. Hydroxyurea (HU) remains the first-line cytoreductive choice; however, up to one in four patients treated with HU over time will develop resistance or intolerance to HU. More importantly, patients who fail HU have a 5.6-fold increase in mortality and a 6.8-fold increase risk of transformation to myelofibrosis or AML; therefore, alternative therapies are needed for these patients. Interferon-α has been used in PV and has shown significant activity in achieving hematologic responses and decreasing JAK2 V617F mutation allele burden. JAK inhibition has also been investigated and recently garnered regulatory approval for this indication. In this review, we will discuss the current treatment options that are available for patients after HU and the novel therapies that are currently under investigation.
Financial Burden of Cancer Clinical Trial Participation and the Impact of a Cancer Care Equity Program
Authors: Nipp Ryan D. , Lee Hang , Powell Elizabeth , Birrer Nicole E. , Poles Emily , Finkelstein Daniel , Winkfield Karen , Percac-Lima Sanja , Chabner Bruce , Moy Beverly 
Published: March 2016

Abstract

Introduction.
Cancer clinical trial (CT) participation rates are low and financial barriers likely play a role. We implemented a cancer care equity program (CCEP) to address financial burden associated with trial participation. We sought to examine the impact of the CCEP on CT enrollment and to assess barriers to participation.

Methods.
We used an interrupted time series design to determine trends in CT enrollment before and after CCEP implementation. Linear regression models compared trial enrollment before and after the CCEP. We also compared patient characteristics before and after the CCEP and between CCEP and non-CCEP participants. We surveyed CCEP and non-CCEP participants to compare pre-enrollment financial barriers.

Results.
After accounting for increased trial availability and the trends in accrual for prior years, we found that enrollment increased after CCEP implementation (18.97 participants per month greater than expected; p &lt; .001). A greater proportion of CCEP participants were younger, female, in phase I trials, lived farther away, had lower incomes, and had metastatic disease. Of 87 participants who completed the financial barriers survey, 49 CCEP and 38 matched, non-CCEP participants responded (63% response rate). CCEP participants were more likely to report concerns regarding finances (56% vs. 11%), medical costs (47% vs. 14%), travel (69% vs. 11%), lodging (60% vs. 9%), and insurance coverage (43% vs. 14%) related to trial participation (all p &lt; .01).

Conclusion.
CT participation increased following implementation of the CCEP and the program enrolled patients experiencing greater financial burden. These findings highlight the need to address the financial burden associated with CT participation.
Finisterra. Biografia de uma revista de geografia (1966-2015)
Authors: Alcoforado Maria João Alcoforado , Alegria Maria Fernanda , Queirós Margarida , Garcia Ricardo A. C. , Morgado Paulo , Vieira Rute 
Published: March 2016

<p>Com a publicação do número 100, celebram-se os 50 anos de Finisterra. Revista Portuguesa de Geografia (1966-2015). Neste texto biográfico, depois de um breve enquadramento, que situa o nascimento da revista, reconstitui-se o percurso das suas estruturas organizativas desde o primeiro número, analisam-se os tipos de textos publicados ao longo do tempo e faz-se uma análise minuciosa e ilustrada dos artigos durante os 50 anos de existência (autores, espaços e temas tratados, idiomas, ilustrações). As principais fases do percurso da revista replicam de algum modo aspectos evolutivos da Geografia. A fase de lançamento (1966-1975) da Finisterra, concebida desde início como uma publicação internacional, acompanhou o aumento do número de geógrafos, bem como o confronto de ideias e de correntes de pensamento contemporâneo. No período seguinte, de consolidação (1976-1994), iniciaram-se alterações nas estruturas organizativas e no aspecto gráfico, ao mesmo tempo que se divulgavam novos temas de investigação geográfica. No período de alterações estruturais (1995-1999) criaram-se outros órgãos consultivos externos, novas normas de publicação e diferentes formas de apresentação dos textos. Pode dizer-se que se lançaram as bases para a fase seguinte, estandardização de procedimentos, internacionalização e difusão em acesso aberto (2000-2015). Nestes anos mantiveram-se as preocupações com o controlo de qualidade dos textos e o aumento da difusão da revista, agora facilitada pela era digital. Em todas as fases, foi determinante o papel dos revisores científicos, cujo empenho silencioso, anónimo e gracioso nos apraz destacar nesta celebração dos 100 números da Finisterra. Parafraseando Ruben A. “o geógrafo não cansa, avança”: são estas as perspectivas para a nova fase, que se iniciará em 2016.</p>
O espaço global de que fazemos parte
Authors: Lago Teresa 
Published: March 2016

<p>Aqui, será o “espaço” físico, o objecto. Para ir direita ao assunto, proponho: numa noite límpida e sem luar deite-se na relva, num local não poluído pela iluminação; olhe bem para o “céu” profundo, esmagador, nos milhares de objectos cintilantes. Contemple a sua beleza. E lembre-se que ocupa uma “nave” que se desloca, nesse espaço, a cerca de 29,8 km/s, em torno de uma estrela (como tantas outras…), o Sol. Mas tenha em conta que, em simultâneo, também ele (e todo o sistema solar) rodam a cerca de 220 km/s em torno do centro da Via Láctea, que pode vislumbrar sobre si, deslumbrante.</p>
As costureiras, as Queens e os seus mantos. Desterritorialização, cultura material e construção do lugar
Authors: Silvano Filomena 
Published: March 2016

<p>Durante as décadas de 1980 e de 1990 a noção de lugar na literatura antropológica<br />foi sujeita a uma abordagem crítica que debateu as dimensões metodológicas e conceptuais envolvidas na sua construção. No seguimento desse debate, surgiram propostas de trabalho que, de maneiras muito diversas, conseguiram ultrapassar as limitações das concepções mais clássicas da figura do lugar. Essas propostas revelaram, no entanto, que, mesmo quando estamos face a uma lógica de desterritorialização, a figura do lugar pode reaparecer (embora obviamente transmutada, visto construir-se no interior de outras lógicas sociais, culturais e económicas). Partindo de um estudo etnográfico realizado na Ilha do Pico, o texto explora algumas das inovações, provenientes dos EUA no início do século XX, que foram introduzidas nas Festas do Espírito Santo. A principal inovação prende-se com a emergência de novos personagens: as rainhas (queens) coroadas durante o ritual, seguidas pelas costureiras indispensáveis à confecção dos seus vestidos e mantos. Centrado nos processos de feitura dos mantos, o texto pretende mostrar como a cultura material local se constrói e se transforma no interior de um movimento transcontinental constante de pessoas, rituais, coisas e técnicas. Num contexto transnacional, a mobilidade das pessoas pode “objectificar-se” em coisas que são feitas localmente, participando assim a desterritorialização na construção do lugar</p>
A balada do Mar Salgado. Viagem filmada por paisagens sem homens
Authors: Carmo Piçarra Maria do Carmo Piçarra 
Published: March 2016

<p>Neste artigo procuro analisar porque é que o filme I cruzeiro de férias às colónias ocidentais, encomendado ao prestigiado fotógrafo de arte San Payo para registar o “primeiro cruzeiro de soberania” organizado pela Agência Geral das Colónias, foi projectado uma única vez durante o Estado Novo. Filme de viagens, um subgénero do cinema colonial de propaganda, é uma das primeiras obras de propaganda oficial com a qual se pretende projectar a ideia de que “Portugal não é um país pequeno”: (re)construir o país através de um novo mapa do império, portanto. Filme-sintoma de uma “cultura de mobilidade”, identificada por Jean Brunhes, quer atestar o domínio do espaço imperial através das novas tecnologias da comunicação. Inconsciente desse fenómeno, da aceleração, terá sido vítima da desintegração do olhar sobre o quotidiano das colónias? Ter-lhe-á faltado, para cumprir o desígnio de projectar a grandeza da nação, um movimento, mais íntimo, da contemplação para a compaixão (Orlando Ribeiro)?</p>
El estado nutricional infantil en contextos de pobreza urbana: ¿indicador fidedigno de la salud familiar?
Authors: Huergo Juliana , Casabona Eugenia Lourdes 
Published: March 2016

Este trabajo pone en discusión la premisa de que el estado nutricional de un niño menor de seis años constituye un indicador fidedigno de la salud familiar. Para ello, se llevó adelante una estrategia de investigación basada en estudios de casos siguiendo un diseño cualitativo (observación participante y entrevistas semiestructuradas mediante un muestreo intencional) enmarcado en el paradigma interpretativista. Además, se valoraron antropométricamente 20 niños menores de seis años asistentes al Centro de Cuidado Infantil de Villa La Tela, Córdoba, Argentina. En ese marco, entendiendo al estado nutricional como un objeto que incluye procesos biológicos socialmente determinados, se lo postuló analíticamente como un cruce entre el dato estadístico y su determinación social. El estado nutricional infantil en tanto dato estadístico es meramente descriptivo y para que colabore con el entendimiento de su determinación social debe ponerse en relación dialéctica con los módulos de sociabilidad que se proponen para el análisis de la reproducción de los problemas de salud.
Cross organizational standardized business process integration and its application in Saudi Arabian banking system regulation: A case study of advanced IRB regulation
Authors: Saghier Hisham Al , Alrabiah Abdulrahman 
Published: March 2016

The idea for this paper came after the recent financial crisis, its global consequences and specifically how it affected the banking sector. Financial institutions and regulators are – from a technical point of view - not fully integrated and automated yet. The inaccuracy in banks’ data and the long set interval period, quarterly, to send the information to the regulators leads to delays interventions by local supervisory regulators. Most of the banks are using an Internal Ratings Based (IRB) approach that allows them to use their own methods to calculate the credit risks, which makes it difficult for the regulators to verify and validate the banks’ data without adopting fully automated connectivity for the regulatory reporting system through sophisticated tools. The importance of this issue, for the central banks as well as the global economy, encourages us to investigate and to find solutions for the problem at hand. This paper is focused on the Advanced Internal Ratings Based (A-IRB) approach to evaluate credit risk due to the importance and the sensitivity of this approach on the banking sector. The flexibility of the A-IRB approach allow banks to use their own method to calculate the credit risk without regulators having the right tools to validate the data is a major issue . The second issue with the A-IRB approach is that the report is only delivered quarterly to the regulator (SAMA). This period is too long as decisions can be taken based on data that is almost a quarter old. Therefore, evaluating the existing framework and solving the issues concurrently is essential to improve the regulatory reporting system. To examine the situation of the regulatory reporting system, first, we reviewed literature on the Basel II&III regulations and the financial crisis, including impacts and responses. The second, we reviewed factors impeding the implementation of Basel II&III, including solutions to increase coordination and integration and a holistic approach that can mitigate the outstanding issues for the Regulatory Reporting System for the local banks in Saudi Arabia. We also evaluated the current system and the proposed system in two workshops and found that the proposed system showed considerable improvements of more than 100% in some areas and hence should be implemented. Our result is a framework solution that integrates a private cloud computing network with automated and integrated features such as a Business Process Manager, a Knowledge Management Engine, a SLA Lifecycle Manager, a Business Rules Engine and a Data Quality Regulator and the Enterprise Service Bus for communication and integration between the banks and SAMA. Keywords: Business Process, Business Rules, Bank Management
Detecting similar opinion holders for massive sentiment analysis
Authors: Alparslan Erdem , Karahoca Adem 
Published: March 2016

Sentiment Analysis is the study of acquisition, extraction and interpretation of human opinions, sentiments, attitudes and emotions from both structured and unstructured data sources. Also called opinion mining, the field is becoming crucial for various application areas including market researches, politics, sociology and economics. Therefore, many outstanding research efforts are performed on the fields including both theoretical and practical aspects. This paper aims to develop a supportive framework for sentiment analysis, focusing on the similarity of opinion holders in a massive dataset. We used e-commerce review dataset of Amazon spanning May 1996 – July 2014. The whole review set includes more than 140 million entries. As a preprocessing task each review is structured and expressed on a quadruple form of 4 dimensions: Target entity, opinion holder, sentiment and time. The aim of this study is to find out similar opinion holders for a given customer on a certain product in real time. We have defined a new method spanning all the opinions of an individual. The idea behind this calculation of similarity is rating of the same product with the same sentiment factor by two different opinion holders. The real-time calculation is also performed on Hadoop clusters. Performance enhancements and accuracy rates are then discussed.Keywords: sentiment analysis, opinion mining, big data analytics, Map-Reduce
The effects of problem based learning on cognitive flexibility, self-regulation skills and students’ achievements
Authors: Yucel Özge , Karahoca Dilek , Karahoca Adem 
Published: March 2016

The purpose of this study is to specify the effects of cognitive flexibility and self-regulation skills on students’ achievements in web mediated problem based programming language learning towards gender and class groups. Self-regulation skills towards web based programming language education is discussed under three dimensions; learning skills, learning strategies and self-efficacy. Level of cognitive flexibility is reviewed by comparison of time and percentage of success. Causal-comparative research model is used in this study where five different class groups are compared in. Furthermore, a web based problem was given to this students and their success is calculates as the grades that they get from each step. As a result, this paper indicates that when the correlation between level of cognitive flexibility and students’ achievements is taken under consideration it is seen that there is a positive linear relationship between them. It can be said that students who have higher cognitive flexibility level also have advanced problem solving skills. Keywords: web-based learning; problem-based learning; cognitive intelligence, self-regulation
EVALUACIÓN DE LA PERCEPCIÓN DE UN PROGRAMA TUTORIAL DIRIGIDO A ESTUDIANTES DE PROVINCIA EN UNA UNIVERSIDAD DE LIMA
Authors: Marcelo Torres Nohemí Estefani 
Published: March 2016

El acompañamiento tutorial, en los últimos años, ha venido cobrando relevancia debido a la implicancia que tiene en el desempeño socioemocional y académico de los estudiantes, es por ello que muchas universidades diseñan planes institucionales que permiten a sus estudiantes fortalecer habilidades y capacidades. En ese sentido, el presente estudio pretende conocer cuáles son las percepciones que tiene un grupo de 30 estudiantes, entre 15 y 18 años, provenientes del interior del país, respecto a las actividades desarrolladas en el programa tutorial del semestre 2014-1. Se empleó un diseño cualitativo de tipo fenomenológico, y para la recolección de datos se emplearon grupos focales y técnicas proyectivas. Los resultados indican que el programa tutorial es concebido por los estudiantes como un espacio de apoyo, escucha que favorece al proceso de adaptación a la vida universitaria, aunque, también, señalan que éste debe ajustarse de acuerdo a las constantes necesidades del grupo.
EL LIBRO DE TEXTO UNIVERSITARIO. UN ENFOQUE METODOLÓGICO
Authors: Reynosa Navarro Enaidy 
Published: March 2016

En el presente trabajo, el lector encontrará pautas metodológicas para la realización de un libro de texto universitario; se sistematizan procedimientos para la conformación del equipo de trabajo encargado de la elaboración de los libros de texto; se explica cómo delimitar las temáticas que pueden ser abordadas; se exponen los procedimientos de gestión de la información, así como la detección de la literatura apropiada. Además, se enfatiza en las formas de indagación teórica, interpretación de teorías, conclusiones teóricas y las funciones didácticas del libro de texto. Por último, se exponen algunas pautas editoriales que van, desde la estructura del libro de texto, notas, referencias bibliográficas, tratamiento de imágenes o tablas, semblanza de los autores, etapa de corrección; hasta la revisión final y puesta en valor de la obra.