bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the impact of missense mutations in hCES1 by in silico structure-based approaches
Authors: Nzabonimpa Grace Shema , Rasmussen Henrik Berg , Brunak Søren , Taboureau Olivier , for the INDICES Consortium  
Published: February 2016

Abstract
Genetic variations in drug-metabolizing enzymes have been reported to influence pharmacokinetics, drug dosage and other aspects that affect therapeutic outcomes. Most particularly, non-synonymous single-nucleotide polymorphisms (nsSNPs) resulting in amino acid changes disrupt potential functional sites responsible for protein activity, structure, or stability, which can account for individual susceptibility to disease and drug response. Investigating the impact of nsSNPs at a protein’s structural level is a key step in understanding the relationship between genetic variants and the resulting phenotypic changes. For this purpose, in silico structure-based approaches have proven their relevance in providing an atomic-level description of the underlying mechanisms. The present review focuses on nsSNPs in human carboxylesterase 1 (hCES1), an enzyme involved in drug metabolism. We highlight how prioritization of functional nsSNPs through computational prediction techniques in combination with structure-based approaches, namely molecular docking and molecular dynamics simulations, is a powerful tool in providing insight into the underlying molecular mechanisms of nsSNPs phenotypic effects at microscopic level. Examples of in silico studies of carboxylesterases (CESs) are discussed, ranging from exploring the effect of mutations on enzyme activity to predicting the metabolism of new hCES1 substrates as well as to guiding rational design of CES-selective inhibitors.
Compact Diplexer with High Isolation based on Novel Symmetric Double Spiral Resonators
Authors: Le Ru , Wensheng Chi , Yaqing Liu , Haidong Yang 
Published: February 2016

AbstractIn this paper, the electromagnetic characteristics of the reported miniaturized bandpass filter (BPF) in reference are investigated deeply, and then a planar compact diplexer centred at 1.86/2.16 GHz is designed by using a T-junction to connect the reported BPFs. For verification, the designed diplexer are fabricated and measured. The measured and simulated results of the diplexer are in good agreement with each other, showing that the measured 3-dB bandwidth for the two passbands are 6.45 % (1.79–1.91 GHz) at 1.86 GHz and 6.94 % (2.08–2.23 GHz) at 2.16 GHz with return losses better than 20 dB. Moreover, the insertion losses of the two passbands are less than 0.7 and 0.9 dB, and the isolations are higher than 48 and 36 dB, respectively. Besides, compared with the diplexers reported in recent references, this one has more superior performances.
Congenital hypothyroidism and thyroid dyshormonogenesis: a case report of siblings with a newly identified mutation in thyroperoxidase
Authors: Sparling David P. , Fabian Kendra , Harik Lara , Jobanputra Vaidehi , Anyane-Yeboa Kwame , Oberfield Sharon E. , Fennoy Ilene 
Published: February 2016

AbstractThyroid dyshormonogenesis continues to be a significant cause of congenital hypothyroidism. Over time, forms of thyroid dyshormonogenesis can result in goiter, which can lead to difficult management decisions as the pathologic changes can both mimic or lead to thyroid cancer.Herein we describe the cases of two brothers diagnosed with congenital hypothyroidism, with initial findings consistent with thyroid dyshormonogenesis. One brother eventually developed multinodular goiter with complex pathology on biopsy, resulting in thyroidectomy.Whole exome sequencing revealed the brothers carry a novel frameshift mutation in thyroperoxidase; the mutation, while not previously described, was likely both deleterious and pathogenic.These cases highlight the complex pathology that can occur within thyroid dyshormonogenesis, with similar appearance to possible thyroid cancer, leading to complex management decisions. They also highlight the role that a genetic diagnosis can play in interpreting the impact of dyshormonogenesis on nodular thyroid development, and the need for long-term follow-up in these patients.
Effects of slip on oscillating fractionalized Maxwell fluid
Authors: Jamil Muhammad 
Published: February 2016

AbstractThe flow of an incompressible fractionalized Maxwell fluid induced by an oscillating plate has been studied, where the no-slip assumption between the wall and the fluid is no longer valid. The solutions obtained for the velocity field and the associated shear stress, written in terms of H-functions, using discrete Laplace transform, satisfy all imposed initial and boundary conditions. The no-slip contributions, that appeared in the general solutions, as expected, tend to zero when slip parameter
Análisis de la posición de la amígdala cerebelosa, con resonancia nuclear magnética, antes y después de la corrección instrumentada por vía posterior en pacientes con escoliosis idiopática del adolescente. [Magnetic Resonance Imaging Evaluation of the Position of the Cerebellar Tonsil before and after Posterior Spinal Fusion in Adolescent Idiopathic Scoliosis.]
Authors: Bosio Santiago Tomas , Puigdevall Miguel , Hokama Jorge , Maenza Ruben 
Published: February 2016

<p><strong>Introducción: </strong>El objetivo de este estudio fue analizar las variaciones de posición de la Amígdala Cerebelosa, con resonancia nuclear magnética, antes y después de la corrección de la deformidad espinal mediante una artrodesis vertebral posterior instrumentada (AVP) en pacientes con escoliosis idiopática del adolescente (EIA) que no presentaban sintomatología neurológica.</p><p><strong>Materiales y métodos:</strong> Se evaluaron retrospectivamente 40 pacientes con EIA que no presentaban síntomas neurológicos y a los cuales se les realizó una AVP instrumentada para corregir la deformidad espinal. Se realizó RNM de la fosa cerebral posterior y de la columna cervical en todos los pacientes antes y después de la cirugía espinal. El nivel de la amígdala cerebelosa con respecto al foramen magnum se midió con el método descripto por <em>Aboulezz et al </em><sup>3</sup>.</p><p><strong>Resultados: </strong>La magnitud pre-operatoria promedio de la curva escoliótica fue de 53,15° (DS 10,46°) y de la cifosis torácica fue de 35,42º (DS 12,38°). En el post-operatorio inmediato la magnitud promedio fue de 7,45º (DS 7,33°) y de 27,87º (DS 9,03°), respectivamente. La corrección promedio lograda con la AVP fue de 86% en el plano coronal (p&lt;0.00001). El valor promedio de la longitud de la columna en el plano coronal fue de 44,5 cm (SD 5,25 cm) en el pre-operatorio y de 48,27 cm (DS 4,40 cm) en el post-operatorio (p&lt;0.00001). El valor promedio de la longitud de la columna vertebral en el plano sagital fue de 50,87 cm (DS 4,47 cm) en el pre-operatorio y de 55,13 cm (DS 3,27 cm) en el post-operatorio (p&lt;0.00001). No se observó una diferencia significativa respecto de la posición de la amígdala cerebelosa en las mediciones realizadas antes y después de corregida la deformidad espinal. (p=0,6042). En 10 de los 40 pacientes, se observó un desplazamiento caudal de la amígdala cerebelosa luego de realizada la AVP. En 21 pacientes no se observó ninguna variación en la posición de la amígdala cerebelosa, y en 2 se observó un desplazamiento cefálico de la misma.</p><p><strong>Conclusión: </strong>No observamos una variación significativa de la ubicación de la amígdala cerebelosa respecto del agujero occipital en pacientes con EIA que fueron sometidos una AVP instrumentada para corregir la deformidad espinal. No se encontró correlación entre la magnitud d</p>
Técnica de Bristow-Latarjet en la inestabilidad glenohumeral anterior. [Bristow-Latarjet Technique in the Treatment of Anterior Shoulder Instability.]
Authors: Jiménez Isidro , Marcos-García Alberto , Medina José , Caballero Jonathan , Muratore Moreno Gustavo 
Published: February 2016

<p><strong>Objetivo:</strong> Analizar los resultados obtenidos a medio plazo en los pacientes que hemos intervenido mediante la técnica de Bristow-Latarjet teniendo en cuenta el valor del ISIS preoperatorio.</p><p class="Sinespaciado"><strong>Material y métodos:</strong> Estudio retrospectivo de 33 pacientes intervenidos entre 2005 y 2012 con edad media de 33 (21-68) años y seguimiento medio de 6 (2-9) años. Se recogió el resultado con las escalas de Rowe y Constant, cuestionario DASH y una encuesta de valoración subjetiva del resultado por parte de cada paciente.</p><p class="Sinespaciado"><strong>Resultados<em>:</em></strong> No hubo recidivas. La puntuación media postoperatoria en la escala de Rowe fue de 74.6 (15-100) puntos y de 70 (32-98) puntos en la escala de Constant. En el cuestionario DASH el valor promedio fue 22.9 (0-73) puntos. El 79% de los pacientes se mostraron satisfechos con el resultado. Se produjo la migración del tornillo en un paciente encontrándose asintomático. No se identificaron otras complicaciones.</p><p class="Sinespaciado"><strong>Conclusiones<em>:</em></strong> Consideramos, como está reflejado en la literatura, que la técnica de Bristow–Latarjet en el tratamiento de la inestabilidad glenohumeral anterior es una técnica fiable y con una baja tasa de recidivas por lo que debe emplearse como cirugía de elección en determinados casos y, para ello, creemos que la valoración preoperatoria con la escala ISIS es una buena guía a la hora de indicar el tipo de cirugía.</p>
Placental Complications and Bronchopulmonary Dysplasia: EPIPAGE-2 Cohort Study
Authors: Torchin Héloïse , Ancel Pierre-Yves , Goffinet François , Hascoët Jean-Michel , Truffert Patrick , Tran Diep , Lebeaux Cécile , Jarreau Pierre-Henri 
Published: February 2016

OBJECTIVE:
To investigate the relationship between placenta-mediated pregnancy complications and bronchopulmonary dysplasia (BPD) in very preterm infants.

METHODS:
National prospective population-based cohort study including 2697 singletons born before 32 weeks’ gestation. The main outcome measure was moderate to severe BPD. Three groups of placenta-mediated pregnancy complications were compared with no placenta-mediated complications: maternal disorders only (gestational hypertension or preeclampsia), fetal disorders only (antenatal growth restriction), and both maternal and fetal disorders.

RESULTS:
Moderate to severe BPD rates were 8% in infants from pregnancies with maternal disorders, 15% from both maternal and fetal disorders, 23% from fetal disorders only, and 9% in the control group (P &lt; .001). When we adjusted for gestational age, the risk of moderate to severe BPD was greater in the groups with fetal disorders only (odds ratio [OR] = 6.6; 95% confidence interval [CI], 4.1–10.7), with maternal and fetal disorders (OR = 3.7; 95% CI, 2.5–5.5), and with maternal disorders only (OR = 1.7; 95% CI, 1.0–2.7) than in the control group. When we also controlled for birth weight, the relationship remained in groups with fetal disorders only (OR = 4.2; 95% CI, 2.1–8.6) and with maternal and fetal disorders (OR = 2.1; 95% CI, 1.1–3.9).

CONCLUSIONS:
Placenta-mediated pregnancy complications with fetal consequences are associated with moderate to severe BPD in very preterm infants independently of gestational age and birth weight, but isolated maternal hypertensive disorders are not. Fetal growth restriction, more than birth weight, could predispose to impaired lung development.
Benefits of Delayed Cord Clamping in Red Blood Cell Alloimmunization
Authors: Garabedian Charles , Rakza Thameur , Drumez Elodie , Poleszczuk Marion , Ghesquiere Louise , Wibaut Bénédicte , Depoortere Marie-Hélène , Vaast Pascal , Storme Laurent , Houfflin-Debarge Véronique 
Published: February 2016

BACKGROUND AND OBJECTIVE:
Several studies have shown the benefits of delayed cord clamping (DCC) in preterm and in healthy newborns at short and long term. Our objective was to evaluate the potentials benefits and risks of DCC in red cell alloimmunization.

METHODS:
This was a comparative before/after study of all living born neonates followed after fetal anemia requiring in utero transfusion. DCC was defined as cord clamping 30 seconds after birth.

RESULTS:
We included a continuous series of 72 neonates: 36 without DDC (group 1) and 36 with DDC (group 2). Hemoglobin at birth was lower in group 1 (10.2 vs 13.4 g/dL, P = .0003); 7 (25%) neonates in group 1 vs 24 (70.6%) in group 2 had no anemia at birth (P = .004). The rate of transfusion was similar between the 2 groups. Postnatal exchange transfusions were more likely performed in the group without DCC than in the group with DCC (47.2% vs 19.4%, P = .0124). Delay between birth and first transfusion was higher in group 2 (0 [0–13] vs 1 [0–21], P = .0274). The maximum level of bilirubin, the rate of intensive phototherapy, and the total duration of phototherapy were similar in the 2 groups.

CONCLUSIONS:
This study highlights a significant benefit of DCC in anemia secondary to red blood cell alloimmunization with a resulting decreased postnatal exchange transfusion needs, an improvement in the hemoglobin level at birth and longer delay between birth and first transfusion with no severe hyperbilirubinemia.
Effective Methods for Teaching Information Literacy Skills to Undergraduate Students: A Systematic Review and Meta-analysis
Authors: Koufogiannakis Denise , Wiebe Natasha 
Published: February 2016

Objective - The objective of this review was to assess which library instruction methods are most effective for improving the information skills of students at an introductory, undergraduate level, using cognitive outcomes (measuring changes in knowledge). The study sought to address the following questions:
1)	What is the overall state of research on this topic?
2)	Which teaching methods are more effective?

Methods - Systematic review methodology was used. Fifteen databases were searched for relevant articles retrieving 4356 potentially relevant citations. Titles and abstracts were reviewed for relevance. Of those, 257 full articles were considered in-depth using a predetermined inclusion/exclusion form. 122 unique studies met the inclusion criteria and underwent an extensive data extraction and critical appraisal process. 55 of these studies met author defined quality criteria to provide information on the effectiveness of different teaching methods. Of these, 16 studies provided sufficient information to enable meta-analyses using standardized mean difference to be undertaken.

Results - The overwhelming majority of studies were conducted in the United States (88%). 79 studies (65%) used experimental or quasi-experimental research methods. Teaching methods used in the studies varied, with the majority focused on traditional methods of teaching, followed by computer assisted instruction, and self-directed independent learning. Studies measured outcomes that correlated with Bloom’s lower levels of learning (Remember, Understand, Apply).

16 studies compared traditional instruction with no instruction, and 12 found a positive outcome. Meta-analysis of the data from 4 of these studies agreed with the positive conclusions favouring traditional instruction. 14 studies compared computer assisted instruction with traditional instruction. 9 of these showed a neutral result, and meta-analysis of 8 of these studies agreed with this neutral result. 6 studies compared self-directed independent learning with no instruction, and meta-analysis of 5 of these agreed that the result was positive in favour of self-directed independent learning.

Conclusions - Based on the results of this meta-analysis, there is sufficient evidence to suggest that computer assisted instruction is as effective as traditional instruction. Evidence also suggests that both traditional instruction and self-directed independent instruction are more effective than no instruction. Additional comparative research needs to be done across different teaching methods. Studies comparing active learning, computer assisted instruction, and self-directed independent learning would greatly enrich the research literature. Further studies utilizing appropriate methodologies and validated research tools would enrich our evidence base, and contribute to the growth of knowledge about effectiveness of particular teaching methods.
Las cooperativas: Una alternativa económica y social frente a la crisis
Authors: Divar Garteiz-Aurrecoa Javier 
Published: February 2016

<p>El Cooperativismo nació como alternativa económica y social, impulsado por la piedad religiosa y reglado bajo los principios democráticos. La solidaridad y la democracia económica hacen de las cooperativas sociedades especialmente resistentes frente a las dificultades económicas.</p><p><strong>Recibido</strong>: 29.05.2013<br /><strong>Aceptado</strong>: 26.06.2013</p>
Algunas consideraciones metodológicas a propósito de la nueva relación entre Estado, Derecho y Justicia Social en el constitucionalismo de mercado europeo
Authors: Lasa López Ainhoa 
Published: February 2016

<p>Las novedades registradas en las últimas décadas en el ordenamiento europeo han introducido un escenario de reflexión con respecto al constitucionalismo del Estado social. Concretamente, la contradicción entre un constitucionalismo gestado en el proceso de construcción del Estado social y la nueva realidad constitucional que plantea la integración europea. Este actual momento constitucional plantea la necesidad de buscar orientaciones metodológicas que ayuden a la comprensión de la confrontación descrita, y entre éstas destacan las que analizan la relación Unión Europea-Estados miembros desde la perspectiva de la crisis de la constitución material de las constituciones nacionales. De hecho, el progresivo desmantelamiento de las bases del Estado social ejemplificaría la confrontación Constitución del Estado social-realidad</p>
A importância da formação humanista para o jovem contemporâneo<br>The importance of humanistic education for the contemporary young
Authors: Stona Délis 
Published: February 2016

O objetivo deste trabalho é de estudar a importância da formação humanista para o jovem contemporâneo e, mais particularmente trazer essa discussão à luz dos conceitos que envolvem tal formação. A pesquisa de cunho bibliográfica expõe através da análise de conteúdo a real importância de ajudar a construir um jovem com a mentalidade humanista. Percepções sobre conceitos e fases da vida do jovem esclarecem o posicionamento e enriquecem as discussões deste trabalho. Para a consecução deste objetivo foi necessário um estudo mais aprofundado sobre como é o perfil do jovem na sociedade contemporânea verificando sua trajetória e qual o impacto esse novo conceito de formação representa para o mesmo. Os resultados permitem afirmar que ainda é necessário refletir sobre a formação da pessoa na idade que vai dos 14 aos 24 anos de idade, sobretudo a partir do resgate histórico que será aqui apresentado. A falta de conhecimento e de vontade ainda é um aspecto negativo para o jovem que busca seu desenvolvimento e crescimento futuro. O resultado dessa busca é a realização pessoal que cada um encontra ao se deparar com seu projeto de vida, fazendo sempre a escolha otimal usando os melhores recursos.
O inconsciente do corpo <br>The unconscious body
Authors: Nedel Filho José Alfredo 
Published: February 2016

A dinâmica inconsciente que depois determina o ser humano escapa da consciência humana, em função da maneira como este inconsciente se formou no corpo. Nós humanos começamos a ter consciência da realidade a partir dos 5 a 6 anos de idade. Não sabemos nada do que aconteceu antes desta idade ou muito pouco. No que ocorreu da concepção até a idade de 6 meses, onde fomos colônia do adulto-mãe, e nossas células guardaram e registraram estes eventos. Existe uma sintonia entre o inconsciente do adulto-mãe e o do filho, mas a direção é dada pelo adulto-mãe, que sem saber, pré orienta toda a vida do neonato através do seu inconsciente, normalmente utilizando o filho como um aliado e um modo compensatório de suas frustrações – quando estas existem.
Dutch Midwives’ Behavior and Determinants in Promoting Healthy Gestational Weight Gain, Phase 1: A Qualitative Approach
Authors: Merkx Astrid , Ausems Marlein , Budé Luc , de Vries Raymond , Nieuwenhuijze Marianne J. 
Published: February 2016

BACKGROUND: A significant contributor to the global threat of obesity is excessive gestational weight gain (GWG). The aim of this article is to explore Dutch primary care midwives’ behaviors in promoting healthy GWG.METHODS: We used the attitude–social influence–self-efficacy (ASE) model to guide interviews with a purposive sample of 6 midwives working in primary care.RESULTS: Midwives reported activities in 3 areas related to GWG: GWG monitoring (weighing and discussing GWG), diet education, and to a lesser degree physical activity education. The determinants from the ASE model were confirmed and other relevant determinants, including midwives’ perception of their role in health promotion, were added.PRACTICE IMPLICATIONS: The identified determinants can be used for quantitative research. Quantitative research is necessary to identify the magnitude of the determinants associated with midwives’ behavior in promoting healthy GWG.
Comparatives Evaluation of Antifertility Potential of Leaves of Bambusa arudinacea retz. and Ficus racemosa Bark Extracts in Female Albino Rats
Authors: Vishal Soni  , Arvind Kumar Jha  , Jaya Dwivedi  , Priyanka Soni  
Published: February 2016

Ethanol and hydroalcoholic (50%) extract of B. arundinacea leaves and 50 % ethanol extract of
F. racemosa barks have been evaluated for antifertility activity in proven fertile rats at a dose of 200 and 400 mg/kg body weight. Plant extracts were tested for their effect on the estrous cycle at two dose level 200 and 400 mg/kg, respectively. Among these three extracts, the hydroalcoholic extracts of F. racemosa was found to be most effective in causing significant antiovulatory activity. The extract did not show any significant changes in structure and function of uterus when given alone, but when given along with ethinyl estradiol, it exhibited significant antiestrognic activity in immature female rats (P<0.001). Preliminary phytochemical screening of these two drugs shows the presence of carbohydrates, tannins, steroids, glycosides, flavonoids, phenolic, terpenoids etc. Histopathological studies of the uterus were carried out to confirm the estrogenic activity.
Chemically Modified Carbon Sensors Mixed or Single for the Determination of Cardiovascular Drug Nafronyl Oxalate in Bulk, Praxilene and Human Fluids
Authors: Amal F. Khorshid  
Published: February 2016

Three novel modified carbon paste sensors (CMCPs) were proposed for the determination of nafronyl potentiometric in bulk, pharmaceutical dosage form; human plasma/urine. The sensors were based on an ion-pair associates of nafronyl silicotungstic acid (Nf-St) (sensor 1), nafronyl silicomolybdic acid (Nf-SM) (sensor 2), a mixture of [(Nf-St) + (Nf-SM)] (sensor 3). The modified sensors showed Nernstian slopes ranging from 58.5±0.5-60.7±0.5 mV over the concentration ranged from 1.0 x 10-7-1.0 x 10-2 M and pH 2.0-6.0 with a detection limit 0.1 nM. The sensors exhibited good selectivity for nafronyl with respect to inorganic /organic cations, sugars and amino acids. The calibration curve, standard addition and potentiometric titration methods were applied for the determination of nafronyl ion in its bulk powder, pharmaceutical dosage form, and human fluids plasma/urine taken from a healthy volunteer and for the monitoring Praxilene tablets in vitro dissolution rates. Sensor 3 was successfully used for the determination the solubility products of ion-pair associates. The results were excellent and satisfactory recovery comparable to those obtained with the British Pharmacopoeia.