bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capillarisin blocks prostate‐specific antigen expression on activation of androgen receptor in prostate carcinoma cells
Authors: Tsui Ke‐Hung , Chang Ying‐Ling , Feng Tsui‐Hsia , Hou Chen‐Pang , Lin Yu‐Hsiang , Yang Pei‐Shan , Lee Bing‐Wei , Juang Horng‐Heng 
Published: November 2017

BackgroundCapillarisin (Cap), an active ingredient of Artemisia capillaris extracts, has known for its anti‐inflammatory, antioxidant, and anticancer properties. Functions of Cap in prostate cancer are not clear. We investigate effects of Cap on downregulation of prostate specific antigen (PSA) via modulation of androgen receptor (AR) in prostate carcinoma cells.MethodsCell proliferation was measured by water‐soluble tetrazolium‐1 (WST‐1) cell proliferation assays. The PSA and AR expressions were assessed by immunoblotting and RT‐qPCR assays. Effects of Cap on PSA expressions were determined by ELISA, immunoblotting, and reporter assays. Co‐immunoprecipitation and immunoblotting assays were used to define the effects of Cap on dissociation of AR‐heat shock protein 90 (Hsp90) interaction.ResultsCap inhibited LNCaP cell growth in a dose‐ and/or time‐dependent way without inducing poly ADP‐Ribose Polymerase (PARP) cleavage. Cap not only effectively suppressed AR and PSA protein expressions, but also attenuated activations of synthetic androgen (R1881) on PSA promoter activity dose‐ and time‐dependently. The Cap pretreatment abrogated effects of R1881 on AR activity by reducing AR translocation to the nucleus. Immunoblotting assays indicated that Cap promoted a degradation of AR proteins dose‐dependently in either cycloheximide pretreated‐LNCaP cells or AR‐ectopic expressed PC‐3 cells. Pretreatment of MG132, a proteasome inhibitor, attenuated effect of Cap on AR degradation. Cap lessened AR stability by dissociation of AR‐Hsp90 interaction.ConclusionsOur results indicated that Cap inhibited growth of LNCaP cells. Cap effectively suppressed androgen activation on AR‐mediated transactivation, which is AR‐dependent through AR degradation and dissociation of AR‐Hsp90 in prostate carcinoma cells.
A new adaptive tracking control scheme of wheeled mobile robot without longitudinal velocity measurement
Authors: Shu Panfeng , Oya Masahiro , Zhao Junjie 
Published: November 2017

SummaryThis paper proposes a new adaptive trajectory tracking control scheme of the wheeled mobile robot without longitudinal velocity measurement. First, based on a kinematic controller, we obtain a new tracking error equation, which is suitable to develop an adaptive controller. Then, we develop a new adaptive trajectory tracking controller, which does not need any accurate values of the wheeled mobile robot parameters, including the driving motor parameters. Moreover, as the longitudinal velocity measurement is still difficult, this controller is developed without longitudinal velocity measurement. In addition, this new adaptive controller introduces a method to improve the control performance. The stability of the closed‐loop system is presented using the direct Lyapunov method. Finally, numerous simulations verify the effectiveness of the new controller.
Facile In Situ Growth of Nanostructured Copper Sulfide Films Directly on FTO Coated Glass Substrates as Efficient Counter Electrodes for Quantum Dot Sensitized Solar Cells
Authors: Bhat Sarpangala Venkataprasad , Dhanasekar Moorthy , Rickey Kelly M. , Ruan Xiulin 
Published: November 2017

AbstractWe report a facile chemical solution deposition method for fabricating nanostructured copper sulfide film directly on fluorine doped tin oxide (FTO) coated glass substrates and demonstrate its use as efficient counter electrodes in quantum dot based solar cells. A typical quantum dot sensitized solar cell with CdS sensitized photo‐anode using this counter electrode shows ∼25% improvement in the power conversion efficiency when compared to the reference device assembled with conventional thermally evaporated gold/FTO counter electrode. The superior electrocatalytic activity of the copper sulfide electrode is also substantiated by potentiostatic I−V curves and electrochemical impedance spectroscopy.
Impact of Receiving Secondary Results from Genomic Research: A 12‐Month Longitudinal Study
Authors: Wynn Julia , Martinez Josue , Bulafka Jessica , Duong Jimmy , Zhang Yuan , Chiuzan Codruta , Preti Jain , Cremona Maria L. , Jobanputra Vaidehi , Fyer Abby J. , Klitzman Robert L. , Appelbaum Paul S. , Chung Wendy K. 
Published: November 2017

AbstractThe impact of returning secondary results from exome sequencing (ES) on patients/participants is important to understand as ES is increasingly utilized in clinical care and research. Participants were recruited from studies using ES and were separated into two arms: 107 who had ES and were offered the choice to learn secondary results (ES group) and 85 who had not yet had ES (No ES group). Questionnaires were administered at baseline and 1 and 12 months, following results disclosure (ES group) or enrollment (No ES group). While the majority (65%) elected to learn all results following pre‐test counseling, it was reduced from the 76% who indicated a desire for all results at baseline. Thirty‐seven percent received results associated with an increased personal disease risk. There were no differences in changes in any of the psychological and social measures from baseline to post‐results disclosure between the ES and No ES groups. Receiving a wide range of secondary findings appeared to have little measurable impact on most participants. The experience of learning secondary results may be related to participants’ previous experiences with genetics, as well as the genetic counseling provided. Future research with a more diverse, genetically naïve group, as well as scalable methods of delivery, is needed.
Immediate results from biofeedback and anorectal electrostimulation in the treatment of paradoxical puborectal muscle contraction in women with obstructed defecation
Authors: Magalhães Germana Mesquita , Vasconcelos Thiago Brasileiro de , Regadas Sthela Maria Murad , Bastos Vasco Pinheiro Diógenes , Almeida Paulo César de , Veras Lusmar Rodrigues 
Published: November 2017

AbstractObjective This study was conducted to evaluate the effects of “biofeedback” (BF), electrostimulation (ES), and of the high-fiber diet associated with behavioral therapy in women with obstructed evacuation and paradoxical puborectalis contraction and to compare the results among these three modalities.Method Thirty-one women were evaluated who fulfilled the Rome III Criteria, and with an electromanometric test positive for the presence of contraction in the evacuation maneuver. These patients were randomized into three groups: group I – conventional treatment of constipation, group II – conventional treatment of constipation associated with biofeedback and group III – conventional treatment of constipation associated with electrostimulation. At the beginning of this study and after six weeks, subjective and objective parameters of the anorectal function were evaluated using the Wexner constipation scoring system, the Bristol scale, an visual analogical scale, and anorectal electromanometry.Results All patients demonstrated improvement in bowel satisfaction, stool frequency, effort and feeling of incomplete evacuation, stool-type modifications, and improvement in the quality of life. On examination, there was increased mean pressure of voluntary contraction in group III (p = 0.043), decreased sensitivity threshold in group II (p = 0.025) and III (p = 0.012) and decreased maximum rectal capacity in group II (p = 0.005). Only 19.4% (n = 6) had their dynamic defecation normalized, and 80.6% (n = 25) expressed clinical, non-instrumental, improvement.Conclusion The conventional treatment of constipation, biofeedback and electrostimulation show a significant subjective improvement in symptoms of obstructed evacuation and in quality of life, regardless of the reversal of the paradoxical puborectalis contraction.
Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation
Authors: Drury Stacy S. , Howell Brittany R. , Jones Christopher , Esteves Kyle , Morin Elyse , Schlesinger Reid , Meyer Jerrold S. , Baker Kate , Sanchez Mar M. 
Published: November 2017

AbstractThe molecular, neurobiological, and physical health impacts of child maltreatment are well established, yet mechanistic pathways remain inadequately defined. Telomere length (TL) decline is an emerging molecular indicator of stress exposure with definitive links to negative health outcomes in maltreated individuals. The multiple confounders endemic to human maltreatment research impede the identification of causal pathways. This study leverages a unique randomized, cross-foster, study design in a naturalistic translational nonhuman primate model of infant maltreatment. At birth, newborn macaques were randomly assigned to either a maltreating or a competent control mother, balancing for sex, biological mother parenting history, and social rank. Offspring TL was measured longitudinally across the first 6 months of life (infancy) from peripheral blood. Hair cortisol accumulation was also determined at 6, 12, and 18 months of age. TL decline was greater in animals randomized to maltreatment, but also interacted with biological mother group. Shorter TL at 6 months was associated with higher mean cortisol levels through 18 months (juvenile period) when controlling for relevant covariates. These results suggest that even under the equivalent social, nutritional, and environmental conditions feasible in naturalistic translational nonhuman primate models, early adverse caregiving results in lasting molecular scars that foreshadow elevated health risk and physiologic dysregulation.
Using an adoption–biological family design to examine associations between maternal trauma, maternal depressive symptoms, and child internalizing and externalizing behaviors
Authors: Grabow Aleksandria Perez , Khurana Atika , Natsuaki Misaki N. , Neiderhiser Jenae M. , Harold Gordon T. , Shaw Daniel S. , Ganiban Jody M. , Reiss David , Leve Leslie D. 
Published: November 2017

AbstractMaternal trauma is a complex risk factor that has been linked to adverse child outcomes, yet the mechanisms underlying this association are not well understood. This study, which included adoptive and biological families, examined the heritable and environmental mechanisms by which maternal trauma and associated depressive symptoms are linked to child internalizing and externalizing behaviors. Path analyses were used to analyze data from 541 adoptive mother–adopted child (AM–AC) dyads and 126 biological mother–biological child (BM–BC) dyads; the two family types were linked through the same biological mother. Rearing mother's trauma was associated with child internalizing and externalizing behaviors in AM–AC and BM–BC dyads, and this association was mediated by rearing mothers’ depressive symptoms, with the exception of biological child externalizing behavior, for which biological mother trauma had a direct influence only. Significant associations between maternal trauma and child behavior in dyads that share only environment (i.e., AM–AC dyads) suggest an environmental mechanism of influence for maternal trauma. Significant associations were also observed between maternal depressive symptoms and child internalizing and externalizing behavior in dyads that were only genetically related, with no shared environment (i.e., BM–AC dyads), suggesting a heritable pathway of influence via maternal depressive symptoms.
Childhood maltreatment moderates the effect of combat exposure on cingulum structural integrity
Authors: Banihashemi Layla , Wallace Meredith L. , Sheu Lei K. , Lee Michael C. , Gianaros Peter J. , Mackenzie Robert P. , Insana Salvatore P. , Germain Anne , Herringa Ryan J. 
Published: November 2017

AbstractLimbic white matter pathways link emotion, cognition, and behavior and are potentially malleable to the influences of traumatic events throughout development. However, the impact of interactions between childhood and later life trauma on limbic white matter pathways has yet to be examined. Here, we examined whether childhood maltreatment moderated the effect of combat exposure on diffusion tensor imaging measures within a sample of military veterans (N = 28). We examined five limbic tracts of interest: two components of the cingulum (cingulum, cingulate gyrus, and cingulum hippocampus [CGH]), the uncinate fasciculus, the fornix/stria terminalis, and the anterior limb of the internal capsule. Using effect sizes, clinically meaningful moderator effects were found only within the CGH. Greater combat exposure was associated with decreased CGH fractional anisotropy (overall structural integrity) and increased CGH radial diffusivity (perpendicular water diffusivity) among individuals with more severe childhood maltreatment. Our findings provide preliminary evidence of the moderating effect of childhood maltreatment on the relationship between combat exposure and CGH structural integrity. These differences in CGH structural integrity could have maladaptive implications for emotion and memory, as well as provide a potential mechanism by which childhood maltreatment induces vulnerability to later life trauma exposure.
Effects of early institutionalization on emotion processing in 12-year-old youth
Authors: Bick Johanna , Luyster Rhiannon , Fox Nathan A. , Zeanah Charles H. , Nelson Charles A. 
Published: November 2017

AbstractWe examined facial emotion recognition in 12-year-olds in a longitudinally followed sample of children with and without exposure to early life psychosocial deprivation (institutional care). Half of the institutionally reared children were randomized into foster care homes during the first years of life. Facial emotion recognition was examined in a behavioral task using morphed images. This same task had been administered when children were 8 years old. Neutral facial expressions were morphed with happy, sad, angry, and fearful emotional facial expressions, and children were asked to identify the emotion of each face, which varied in intensity. Consistent with our previous report, we show that some areas of emotion processing, involving the recognition of happy and fearful faces, are affected by early deprivation, whereas other areas, involving the recognition of sad and angry faces, appear to be unaffected. We also show that early intervention can have a lasting positive impact, normalizing developmental trajectories of processing negative emotions (fear) into the late childhood/preadolescent period.
External-environmental and internal-health early life predictors of adolescent development
Authors: Hartman Sarah , Li Zhi , Nettle Daniel , Belsky Jay 
Published: November 2017

AbstractA wealth of evidence documents associations between various aspects of the rearing environment and later development. Two evolutionary-inspired models advance explanations for why and how such early experiences shape later functioning: (a) the external-prediction model, which highlights the role of the early environment (e.g., parenting) in regulating children's development, and (b) the internal-prediction model, which emphasizes internal state (i.e., health) as the critical regulator. Thus, by using data from the NICHD Study of Early Child Care and Youth Development, the current project draws from both models by investigating whether the effect of the early environment on later adolescent functioning is subject to an indirect effect by internal-health variables. Results showed a significant indirect effect of internal health on the relation between the early environment and adolescent behavior. Specifically, early environmental adversity during the first 5 years of life predicted lower quality health during childhood, which then led to problematic adolescent functioning and earlier age of menarche for girls. In addition, for girls, early adversity predicted lower quality health that forecasted earlier age of menarche leading to increased adolescent risk taking. The discussion highlights the importance of integrating both internal and external models to further understand the developmental processes that effect adolescent behavior.
Assessing the interplay between multigenic and environmental influences on adolescent to adult pathways of antisocial behaviors
Authors: Li James J. 
Published: November 2017

AbstractThe current investigation utilized a developmental psychopathology approach to test the hypothesis that multigenic (i.e., dopaminergic and serotonergic genes) and multienvironmental factors interactively contribute to developmental pathways of antisocial behavior (ASB). A sample of 8,834 Caucasian individuals from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were used to (a) examine the developmental pathways of ASB from age 13 to 32 using growth mixture modeling, (b) compute weighted multigenic risk scores (Add Health MRS) for ASB from six well-characterized polymorphisms in dopamine and serotonin genes, and (c) test the interaction between the Add Health MRS and a measures of support (incorporating indicators of both positive and negative support from parents and schools). Four pathways of adolescent to adult ASB emerged from the growth mixture models: low, adolescence-peaked, high decline, and persistent. Add Health MRS predicted the persistent ASB pathway, but not other ASB pathways. Males with high Add Health MRS, but not low MRS, had significantly greater odds of being in the adolescence-peaked pathway relative to the low pathway at low levels of school connectedness. Nonfamilial environmental influences during adolescence may have a cumulative impact on the development of ASB, particularly among males with greater underlying genetic risks.
Dysregulation of the miR-146a-Smad4 axis impairs osteogenesis of bone mesenchymal stem cells under inflammation
Authors: Kuang Wei , Zheng Liwei , Xu Xin , Lin Yao , Lin Jiong , Wu Jiahua , Tan Jiali 
Published: November 2017

AbstractOsteoporosis is a common disease that affects patient quality of life, especially among the elderly population. Although inflammation contributes significantly to osteoporosis, the underlying mechanism is unclear. In this study, we found that tumor necrosis factor (TNF)-α, an inflammatory environment mimic, inhibits osteogenesis of bone mesenchymal stem cells (BMSCs), induces miR-146a and decreases Smad4. Moreover, overexpression of miR-146a inhibited the osteogenic ability of BMSCs, whereas blocking miR-146a partially rescued the osteogenesis deficiency under TNF-α treatment. Molecularly, miR-146a decreased Smad4 expression at the protein level by binding to an element located in the Smad4 3′-untranslated region, and restoration of Smad4 reversed the inhibitory effects of miR-146a on osteogenesis. Together, our results showed that the inflammatory environment mimic TNF-α inhibits osteogenesis via upregulation of miR-146a and subsequent downregulation of Smad4, thus suggesting that therapeutic manipulation of miR-146a maybe a potential strategy to improve osteogenesis in the context of osteoporosis.
Meta-analysis of the interaction between serotonin transporter promoter variant, stress, and posttraumatic stress disorder
Authors: Zhao Mingzhe , Yang Jiarun , Wang Wenbo , Ma Jingsong , Zhang Jian , Zhao Xueyan , Qiu Xiaohui , Yang Xiuxian , Qiao Zhengxue , Song Xuejia , Wang Lin , Jiang Shixiang , Zhao Erying , Yang Yanjie 
Published: November 2017

AbstractExposure to stress predicts the occurrence of posttraumatic stress disorder (PTSD) in individuals harboring the serotonin transporter promoter variant 5-HTTLPR. We carried out a meta-analysis of studies investigating the interaction between 5-HTTLPR, stress, and PTSD to clarify the interrelatedness of these factors. We reviewed all relevant studies published in English before May 2016. The Lipták–Stouffer z-score method for meta-analysis was applied to combined data. The z score was separately calculated for the stressful life events, childhood adversity, bi- and triallelic loci, and cross-sectional and longitudinal studies subgroups. A total of 14 studies with 15,883 subjects met our inclusion criteria. We found strong evidence that the presence of 5-HTTLPR influenced the relationship between stress and PTSD (P = 0.00003), with the strongest effects observed in the cross-sectional and longitudinal groups (P = 0.01 and 2.0 × 10−6, respectively). Stressful life events and childhood adversity separately interacted with 5-HTTLPR in PTSD (P = 2.0 × 10−8 and 0.003, respectively). When the studies were stratified by locus classification, the evidence was stronger for the triallelic (P = 4.0 × 10−8) than for the biallelic (P = 0.054) locus subgroup. There was strong evidence that 5-HTTLPR influences the relationship between stress and PTSD.
A flexible plasma-treated silver-nanowire electrode for organic light-emitting devices
Authors: Li Jun , Tao Ye , Chen Shufen , Li Huiying , Chen Ping , Wei Meng-zhu , Wang Hu , Li Kun , Mazzeo Marco , Duan Yu 
Published: November 2017

AbstractSilver nanowires (AgNWs) are a promising candidate to replace indium tin oxide (ITO) as transparent electrode material. However, the loose contact at the junction of the AgNWs and residual surfactant polyvinylpyrrolidone (PVP) increase the sheet resistance of the AgNWs. In this paper, an argon (Ar) plasma treatment method is applied to pristine AgNWs to remove the PVP layer and enhance the contact between AgNWs. By adjusting the processing time, we obtained AgNWs with a sheet resistance of 7.2Ω/□ and a transmittance of 78% at 550 nm. To reduce the surface roughness of the AgNWs, a peel-off process was used to transfer the AgNWs to a flexible NOA63 substrate. Then, an OLED was fabricated with the plasma-treated AgNWs electrode as anode. The highest brightness (27000 cd/m2) and current efficiency (11.8 cd/A) was achieved with a 30 nm thick light emitting layer of tris-(8-hydroxyquinoline) aluminum doped with 1% 10-(2-benzothiazolyl)-2,3,6,7-tetrahydro-1,1,7,7-tetramethyl-1H,5 H,11H-(1)-benzopyropyrano(6,7-8-I,j)quinolizin-11-one. Compared to thermal annealing, the plasma-treated AgNW film has a lower sheet resistance, a shorter processing time, and a better hole-injection. Our results indicate that plasma treatment is an effective and efficient method to enhance the conductivity of AgNW films, and the plasma-treated AgNW electrode is suitable to manufacture flexible organic optoelectronic devices.
Pressure-induced magnetic moment abnormal increase in Mn2FeAl and non-continuing decrease in Fe2MnAl via first principles
Authors: Ze-Jin Yang , Qing-He Gao , Heng-Na Xiong , Ju-Xiang Shao , Xian-Wei Wang , Zhi-Jun Xu 
Published: November 2017

AbstractThe magnetism of Fe2MnAl and Mn2FeAl compounds are studied by first principles. Evolutions of magnetic moment of Fe2MnAl display distinct variation trends under pressure, showing three different slopes at different pressure intervals, 0~100 GPa, 100~250 GPa, 250–400 GPa, respectively, and the moment collapses finally at 450 GPa. The magnetic moment of Mn2FeAl shows an increasing tendency below 40 GPa and decreases subsequently with pressure, and collapses ultimately at about 175 GPa. Such non-continuing decrease of Fe2MnAl originates from the unusual charge transfer of Fe and Mn and bond populations rearrangement of Fe-Fe and Mn-Fe, whereas the distinct moment evolution of Mn2FeAl is attributed to the complicated distributions of bond populations. The half-metallicity of the compounds can be maintained at low pressure, below about 100 GPa in Fe2MnAl and 50 GPa in Mn2FeAl. The magnetic moment collapse process didn’t induce volume and bond length anomalies in the two compounds, the unique anomaly is the elastic softening behaviour in elastic constant c44 and shear (G) and Young’s (E) moduli of Fe2MnAl at 270 GPa, where the second moment collapse occurs.