bluuebunny/crossref_metadata_2025_split huggingface dataset:
Species associations of congeneric species in a tropical seasonal rain forest of China
Authors: Lan Guoyu , Zhang Yunbing , He Fangliang , Hu Yuehua , Zhu Hua , Cao Min 
Published: April 2016

Abstract:In tropical plant communities with diverse species, many congeners are found to coexist. Do environment or biotic interactions structure the coexistence of congeners in tropical forest communities? In this paper, we aimed to disentangle the effect of environment (first-order effects) and species interactions (second-order effects) on the spatial distributions of tree species. We used a classification scheme and torus-translation to test the first-order interaction of 48 species from 17 genera in a fully mapped 20-ha dipterocarp tropical seasonal rain-forest plot in Xishuangbanna, south-west China. Then we used heterogeneous Poisson null models to reveal significant uni- and bivariate second-order interactions. The results demonstrated that (1) 34 of the 48 studied species showed a significant relation with at least one topographic variable. This confirmed that topographical heterogeneity is important for distribution of these congeners. Spatial segregation (36.6%) and partial overlap (34.8%) were the most common bivariate association types in Xishuangbanna plot, which indicated first-order effects (environment) were strong. (2) For small-scale associations, 51% saplings (1 to ≤ 5 cm) (68.8% for large trees with dbh > 5 cm) of the species showed non-significant associations. For large-scale associations, 61.6% saplings (81.2% for large trees) of the species showed non-significant associations. Lack of significant species interactions provides evidence for the unified neutral theory. In conclusion, both environment and biotic interactions structure congeneric species' coexistence in tropical seasonal rain forest in this region.
A graph-theoretic implementation of the Rabo-de-Bacalhau transformation grammar
Authors: Strobbe Tiemen , Eloy Sara , Pauwels Pieter , Verstraeten Ruben , De Meyer Ronald , Van Campenhout Jan 
Published: April 2016

AbstractShape grammars are rule-based formalisms for the specification of shape languages. Most of the existing shape grammars are developed on paper and have not been implemented computationally thus far. Nevertheless, the computer implementation of shape grammar is an important research question, not only to automate design analysis and generation, but also to extend the impact of shape grammars toward design practice and computer-aided design tools. In this paper, we investigate the implementation of shape grammars on a computer system, using a graph-theoretic representation. In particular, we describe and evaluate the implementation of the existing Rabo-de-Bacalhau transformation grammar. A practical step-by-step approach is presented, together with a discussion of important findings noticed during the implementation and evaluation. The proposed approach is shown to be both feasible and valuable in several aspects: we show how the attempt to implement a grammar on a computer system leads to a deeper understanding of that grammar, and might result in the further development of the grammar; we show how the proposed approach is embedded within a commercial computer-aided design environment to make the shape grammar formalism more accessible to students and practitioners, thereby increasing the impact of grammars on design practice; and the proposed step-by-step implementation approach has shown to be feasible for the implementation of the Rabo-de-Bacalhau transformation grammar, but can also be generalized using different ontologies for the implementation.
Beyond analogy: A model of bioinspiration for creative design
Authors: Salgueiredo Camila Freitas , Hatchuel Armand 
Published: April 2016

AbstractIs biologically inspired design only an analogical transfer from biology to engineering? Actually, nature does not always bring “hands-on” solutions that can be analogically applied in classic engineering. Then, what are the different operations that are involved in the bioinspiration process and what are the conditions allowing this process to produce a bioinspired design? In this paper, we model the whole design process in which bioinspiration is only one element. To build this model, we use a general design theory, concept–knowledge theory, because it allows one to capture analogy as well as all other knowledge changes that lead to the design of a bioinspired solution. We ground this model on well-described examples of biologically inspired designs available in the scientific literature. These examples include Flectofin®, a hingeless flapping mechanism conceived for façade shading, and WhalePower technology, the introduction of bumps on the leading edge of airfoils to improve aerodynamic properties. Our modeling disentangles the analogical aspects of the biologically inspired design process, and highlights the expansions occurring in both knowledge bases, scientific (nonbiological) and biological, as well as the impact of these expansions in the generation of new concepts (concept partitioning). This model also shows that bioinspired design requires a special form of collaboration between engineers and biologists. Contrasting with the classic one-way transfer between biology and engineering that is assumed in the literature, the concept–knowledge framework shows that these collaborations must be “mutually inspirational” because both biological and engineering knowledge expansions are needed to reach a novel solution.
A study on the effects of example familiarity and modality on design fixation
Authors: Viswanathan Vimal , Tomko Megan , Linsey Julie 
Published: April 2016

AbstractDesign fixation is a factor that negatively influences the generation of novel design concepts (Jansson & Smith, 1991). When designers fixate, they tend to reproduce example features or features from their initial ideas. In order to mitigate design fixation, it is crucial to identify the factors that influence the extent of design fixation. This paper investigates two such factors: the modality of examples and the familiarity of designers with the example features. To investigate this, an experiment is conducted with mechanical engineering students who were asked to generate ideas to solve a peanut sheller design problem. The students generated ideas in five different experimental conditions: control, where no example was given; the first example given in a sketch form; the first example given as a nonfunctional prototype; a second example in sketch form; and the second example in a working prototype form. The first example was a nonfeasible solution, but it contained several features familiar to the participants. The second example was a feasible solution, but it contained less familiar features. In order to understand the extent of fixation triggered by the examples, three metrics were utilized to compare across the experimental conditions: the quantity of nonredundant ideas generated by the participants, the presence of example features in their solutions, and their fixation to the example's energy source. The results showed that in the case of the familiar example, the example modality did play an important role in the extent of design fixation. Across the examples, it was found that the first example containing several familiar features caused more fixation than the second one. Overall, this paper shows that the modality in which the example was communicated and the presence of familiar features in an example influenced the fixation caused by those examples.
Presence of Balamuthia mandrillaris in hot springs from Mazandaran province, northern Iran
Authors: LATIFI A. R. , NIYYATI M. , LORENZO-MORALES J. , HAGHIGHI A. , SEYYED TABAEI S. J. , LASJERDI Z. 
Published: April 2016

SUMMARYBalamuthia mandrillaris is an opportunistic free-living amoeba that has been reported to cause cutaneous lesions and Balamuthia amoebic encephalitis. The biology and environmental distribution of B. mandrillaris is still poorly understood and isolation of this pathogen from the environment is a rare event. Previous studies have reported that the presence of B. mandrillaris in the environment in Iran may be common. However, no clinical cases have been reported so far in this country. In the present study, a survey was conducted in order to evaluate the presence of B. mandrillaris in hot-spring samples of northern Iran. A total of 66 water samples were analysed using morphological and molecular tools. Positive samples by microscopy were confirmed by performing PCR amplification of the 16S rRNA gene of B. mandrillaris. Sequencing of the positive amplicons was also performed to confirm morphological data. Two of the 66 collected water samples were positive for B. mandrillaris after morphological and molecular identification. Interestingly, both positive hot springs had low pH values and temperatures ranging from 32 °C to 42 °C. Many locals and tourists use both hot springs due to their medicinal properties and thus contact with water bodies containing the organism increases the likelihood of infection. To the best of our knowledge, this is the first report on the isolation of B. mandrillaris from hot-spring sources related to human activity. Therefore, B. mandrillaris should be considered as a possible causative agent if cases of encephalitis are suspected following immersion in hot springs in addition to Acanthamoeba and Naegleria.
Cities, nations and divine service: identifying Spanish merchants in late medieval Bruges
Authors: BROWN ANDREW 
Published: April 2016

ABSTRACTThis article explores the relationship between ‘national identity’, the urban environment and its religious practices. As a gateway city, where locals met foreigners to an unusual degree, late medieval Bruges provides a useful case-study. The focus is on the processes that shaped expressions of identity. These often involved religious rhetoric and practices. Foreign merchants, such as the Biscayans and Castilians, were grouped into ‘nations’, and identified with their homelands, especially in their chapels; but why and how they did so was not the result simply of patriotism or a sense of otherness, but of urban and strategic agendas, their own and those of native citizens.
Giant aneurysm of the vertical vein in a case of supracardiac total anomalous pulmonary venous connection
Authors: Phadke Milind S. , Mate Swapnil D. , Kerkar Prafulla G. 
Published: April 2016

AbstractA 17-year-old female presented with mild cyanosis. Imaging showed supracardiac total anomalous pulmonary venous connections with a vertical vein travelling between the left pulmonary artery and the left bronchus with significant obstruction. There was a huge post-stenotic aneurysm of the vertical vein.
Diet quality in European pre-schoolers: evaluation based on diet quality indices and association with gender, socio-economic status and overweight, the ToyBox-study
Authors: Pinket An-Sofie , De Craemer Marieke , Huybrechts Inge , De Bourdeaudhuij Ilse , Deforche Benedicte , Cardon Greet , Androutsos Odysseas , Koletzko Berthold , Moreno Luis , Socha Piotr , Iotova Violeta , Manios Yannis , Van Lippevelde Wendy 
Published: April 2016

AbstractObjectiveTo study diet quality among pre-schoolers using the Diet Quality Index (DQI) and to investigate differences according to gender, socio-economic status (SES) and overweight/obesity status.DesignKindergarten-based cross-sectional survey within the ToyBox-study. A standardized protocol was used and parents/caregivers self-reported sociodemographic data and a semi-quantitative FFQ. A total DQI and its four subcomponents (diversity, quality, equilibrium and meal index) were calculated based on this FFQ. High total DQI scores indicate better diet quality than low scores. Results of the total DQI and the subcomponents were reported as percentages of maximum scores (100 %).SettingKindergartens in six European countries (Belgium, Bulgaria, Germany, Greece, Poland and Spain).SubjectsEuropean pre-schoolers (aged 3·5–5·5 years) and their parents/caregivers (n7063).ResultsThe mean total DQI score was 68·3 %. Mean scores of the subcomponents were 61·7 % for diversity, 56·5 % for quality, 65·4 % for equilibrium and 89·7 % for the meal index. Pre-schoolers of lower-SES backgrounds had lower scores on the total DQI and all its subcomponents. No clear differences were found by gender and overweight status. Results differed slightly according to country.ConclusionsPre-schoolers scored low on the total DQI and especially on dietary quality, as energy-dense, low-nutritious food items were more often consumed than highly nutritious food items. Furthermore, already in pre-schoolers lower-SES mothers were less likely to provide a good diet quality and this was consistent for all four subcomponents of the total DQI. Food intake in pre-schoolers should be enhanced, especially in pre-schoolers of lower-SES backgrounds.
Dietary associations of fathers and their children between the ages of 20 months and 5 years
Authors: Walsh Adam D , Cameron Adrian J , Crawford David , Hesketh Kylie D , Campbell Karen J 
Published: April 2016

AbstractObjectiveTo examine associations between dietary intakes of fathers and their children at child age 20 months, 3·5 years and 5 years, and to determine if fathers’ intake predicts change in children’s intake between 20 months and 3·5 and 5 years of age.DesignThe diets of fathers and their first-born children participating in the longitudinal Melbourne Infant Feeding Activity and Nutrition Trial (InFANT) Program were assessed using FFQ and three 24 h recalls, respectively.SettingSixty-two pre-existing first-time parent groups were selected from fourteen local government areas within a 60 km radius of Deakin University Burwood, Victoria, Australia.SubjectsFathers and their first-born children at 20 months (n317), 3·5 years (n214) and 5 years of age (n208).ResultsPositive associations were found between fathers’ and children’s intakes of fruit and sweet snacks at 20 months (P=0·001) and 5 years of age (P=0·012). Fathers’ intake at child age 20 months was associated with change in children’s intake for fruit, sweet snacks and sugar-sweetened beverages between child age 20 months and 3·5 years, and for sweet snacks and sugar-sweetened beverages between child age 20 months and 5 years (allP<0·05). After adjustment for maternal intake, fathers’ intake of sweet snacks remained a predictor of change in children’s sweet snack intake between 20 months and 3·5 years of age (P=0·03).ConclusionsAssociations between the dietary intakes of fathers and their children commence at a young age and continue through early childhood. Fathers should be included in future interventions aimed at improving children’s diets.
Pursuing “effective measures” relating to nuclear disarmament: Ways of making a legal obligation a reality
Authors: Dunworth Treasa 
Published: April 2016

AbstractThis paper argues that pursuing negotiations in good faith on effective measures for nuclear disarmament is a legal obligation, not a foreign policy option. Drawing on the New Agenda Coalition paper of April 2014, which identified some pathways by which nuclear disarmament might be pursued, this paper identifies and analyzes international legal issues raised by each of those pathways. The paper concludes by explaining why legal analysis and discussion are important even in the absence of a settled political commitment to nuclear disarmament.
Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death
Authors: Martin R , Desponds C , Eren R O , Quadroni M , Thome M , Fasel N 
Published: April 2016

AbstractThe mammalian target of rapamycin complex 1 (mTORC1) is a highly conserved protein complex regulating key pathways in cell growth. Hyperactivation of mTORC1 is implicated in numerous cancers, thus making it a potential broad-spectrum chemotherapeutic target. Here, we characterized how mTORC1 responds to cell death induced by various anticancer drugs such rapamycin, etoposide, cisplatin, curcumin, staurosporine and Fas ligand. All treatments induced cleavage in the mTORC1 component, raptor, resulting in decreased raptor–mTOR interaction and subsequent inhibition of the mTORC1-mediated phosphorylation of downstream substrates (S6K and 4E-BP1). The cleavage was primarily mediated by caspase-6 and occurred at two sites. Mutagenesis at one of these sites, conferred resistance to cell death, indicating that raptor cleavage is important in chemotherapeutic apoptosis.
Guided post-acceleration of laser-driven ions by a miniature modular structure
Authors: Kar Satyabrata , Ahmed Hamad , Prasad Rajendra , Cerchez Mirela , Brauckmann Stephanie , Aurand Bastian , Cantono Giada , Hadjisolomou Prokopis , Lewis Ciaran L. S. , Macchi Andrea , Nersisyan Gagik , Robinson Alexander P. L. , Schroer Anna M. , Swantusch Marco , Zepf Matt , Willi Oswald , Borghesi Marco 
Published: April 2016

AbstractAll-optical approaches to particle acceleration are currently attracting a significant research effort internationally. Although characterized by exceptional transverse and longitudinal emittance, laser-driven ion beams currently have limitations in terms of peak ion energy, bandwidth of the energy spectrum and beam divergence. Here we introduce the concept of a versatile, miniature linear accelerating module, which, by employing laser-excited electromagnetic pulses directed along a helical path surrounding the laser-accelerated ion beams, addresses these shortcomings simultaneously. In a proof-of-principle experiment on a university-scale system, we demonstrate post-acceleration of laser-driven protons from a flat foil at a rate of 0.5 GeV m−1, already beyond what can be sustained by conventional accelerator technologies, with dynamic beam collimation and energy selection. These results open up new opportunities for the development of extremely compact and cost-effective ion accelerators for both established and innovative applications.
Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution
Authors: Lee Wook-Bin , Kang Ji-Seon , Choi Won Young , Zhang Quanri , Kim Chul Han , Choi Un Yung , Kim-Ha Jeongsil , Kim Young-Joon 
Published: April 2016

AbstractIn response to persistent mycobacteria infection, the host induces a granuloma, which often fails to eradicate bacteria and results in tissue damage. Diverse host receptors are required to control the formation and resolution of granuloma, but little is known concerning their regulatory interactions. Here we show that Mincle, the inducible receptor for mycobacterial cord factor, is the key switch for the transition of macrophages from cytokine expression to high nitric oxide production. In addition to its stimulatory role on TLR-mediated transcription, Mincle enhanced the translation of key genes required for nitric oxide synthesis through p38 and eIF5A hypusination, leading to granuloma resolution. Thus, Mincle has dual functions in the promotion and subsequent resolution of inflammation during anti-mycobacterial defence using both transcriptional and translational controls.
TNF is a key cytokine mediating neutrophil cytotoxic activity in breast cancer patients
Authors: Comen Elizabeth , Wojnarowicz Paulina , Seshan Venkatraman E , Shah Riddhi , Coker Courtney , Norton Larry , Benezra Robert 
Published: April 2016

AbstractWe have previously shown a novel antimetastatic role for neutrophils in the premetastatic lung of mice in models of breast cancer. Here we expand on those findings in the context of human breast cancer. We assessed the cytotoxicity of neutrophils from 90 newly diagnosed breast cancer patients, 24 ductal carcinoma in situ patients, 56 metastatic breast cancer patients, and 64 women with no history of cancer. We report that neutrophils from metastatic and newly diagnosed breast cancer patients are significantly more cytotoxic than neutrophils from cancer-free individuals. We hypothesized that tumor-secreted factors ‘prime’ neutrophils to become cytotoxic. To identify these factors we assayed for cytokines in serum from 54 breast cancer patients and 35 cancer-free controls. Tumor necrosis factor (TNFα), MCP-1 (CCL2), and IL1RA significantly correlated with cytotoxicity and directly stimulated neutrophil cytotoxicity ex vivo. RNA-seq analyses found protein kinase C iota (PRKCI) to be over expressed in patient neutrophils relative to neutrophils from cancer-free individuals. PRKCI has been implicated in NADPH oxidase assembly, required for neutrophil-mediated cell cytotoxicity. Treatment of human neutrophils with TNF-induced PRKCI expression and cytotoxicity in samples that had low basal levels of PRKCI expression. To date, this work is the first to demonstrate the cytotoxic role of neutrophils in the peripheral blood of a large cohort of breast cancer patients, and that select cytokines appear to mediate the stimulation of neutrophil cytotoxicity. Further functional studies are necessary to identify clinically relevant means of stimulating neutrophil cytotoxicity as an effective barrier against disease progression and metastasis.
Downregulation of YAP-dependent Nupr1 promotes tumor-repopulating cell growth in soft matrices
Authors: Jia Q , Zhou W , Yao W , Yang F , Zhang S , Singh R , Chen J , Chen J J , Zhang Y , Wei F , Zhang Y , Jia H , Wang N 
Published: April 2016

AbstractDespite decades of significant progress in understanding the molecular mechanisms of malignant tumorigenic cells, it remains elusive what these tumorigenic cells are and what controls the growth of these malignant cells. Recently, we have mechanically selected and grown highly malignant and tumorigenic tumor-repopulating cells (TRCs), a small sub-population of cancer cells, by culturing single cancer cells in soft fibrin matrices. However, it is unclear what regulates TRC growth besides Sox2. Here we show that nuclear protein 1 (Nupr1), a protein independent of Sox2, is downregulated in TRCs of melanoma, ovarian cancer and breast cancer cultured in soft fibrin matrices. Nupr1 expression depends on nuclear translocation of YAP that is enriched at the Nupr1 promoter sites; YAP is controlled by Cdc42-mediated F-actin and Lats1 interactions. Nupr1 regulates tumor-suppressor p53 and negatively regulates Nestin and Tert that are independent of Sox2 and promote TRC growth. Silencing Nupr1 increases TRC growth and Nupr1 overexpression inhibits TRC growth in culture and in immune-competent mice. Our results suggest that Nupr1 is a suppressor of growth of highly tumorigenic TRCs and may have a critical role in cancer progression.