bluuebunny/crossref_metadata_2025_split huggingface dataset:
An ultra scale‐down methodology to characterize aspects of the response of human cells to processing by membrane separation operations
Authors: Masri Maria Fernanda , Lawrence Kate , Wall Ivan , Hoare Michael 
Published: January 2017

ABSTRACTTools that allow cost‐effective screening of the susceptibility of cell lines to operating conditions which may apply during full scale processing are central to the rapid development of robust processes for cell‐based therapies. In this paper, an ultra scale‐down (USD) device has been developed for the characterization of the response of a human cell line to membrane‐based processing, using just a small quantity of cells that is often all that is available at the early discovery stage. The cell line used to develop the measurements was a clinically relevant human fibroblast cell line. The impact was evaluated by cell damage on completion of membrane processing as assessed by trypan blue exclusion and release of intracellular lactate dehydrogenase (LDH). Similar insight was gained from both methods and this allowed the extension of the use of the LDH measurements to examine cell damage as it occurs during processing by a combination of LDH appearance in the permeate and mass balancing of the overall operation. Transmission of LDH was investigated with time of operation and for the two disc speeds investigated (6,000 and 10,000 rpm or ϵmax ≈ 1.9 and 13.5 W mL−1, respectively). As expected, increased energy dissipation rate led to increased transmission as well as significant increases in rate and extent of cell damage. The method developed can be used to test the impact of varying operating conditions and cell lines on cell damage and morphological changes. Biotechnol. Bioeng. 2017;114: 1241–1251. © 2017 The Authors. Biotechnology and Bioengineering Published by Wiley Periodicals, Inc.
Long-term outcomes of radiofrequency ablation combined with hepatectomy compared with hepatectomy alone for colorectal liver metastases
Authors: Imai K , Allard M-A , Castro Benitez C , Vibert E , Sa Cunha A , Cherqui D , Castaing D , Baba H , Adam R 
Published: January 2017

Abstract

Background
Combining radiofrequency ablation (RFA) with hepatectomy may enable treatment with curative intent for patients with colorectal liver metastasis (CRLM). However, the oncological outcomes in comparison with resection alone remain to be clarified.

Methods
Patients who underwent a first hepatectomy between 2001 and 2012 for CRLM were enrolled. Short- and long-term outcomes of patients who underwent hepatectomy plus RFA were compared with those of patients who had hepatectomy alone using propensity score matching.

Results
Of a total of 553 patients, hepatectomy + RFA and hepatectomy alone were performed in 37 and 516 respectively. Before matching, patients in the hepatectomy + RFA group were characterized primarily by a larger tumour burden. After matching of 31 patients who underwent hepatectomy + RFA with 93 who had hepatectomy alone, background characteristics were well balanced. In the matched cohort, overall and disease-free survival in the hepatectomy + RFA group were no different from those among patients who had hepatectomy alone (5-year overall survival rate 57 versus 61 per cent, P = 0·649; 5-year disease-free survival rate 19 versus 17 per cent, P = 0·865). Local recurrence at the ablated site was observed in four of 31 patients (13 per cent). Although overall local recurrence (ablated site and/or cut surface) was more frequent in the hepatectomy + RFA group (9 of 31 (29 per cent) versus 11 of 93 (12 per cent); P = 0·032), there was no difference in intrahepatic disease-free survival between the two groups (P = 0·705).

Conclusion
Hepatectomy + RFA achieved outcomes comparable to hepatectomy alone. Combining RFA with hepatectomy should be considered as an option to achieve cure.
Efficacy and safety of a biodegradable polymer Cobalt‐Chromium sirolimus‐eluting stent (EXCEL2) in treating de novo coronary artery disease: A pooled analysis of the CREDIT II and CREDIT III trials
Authors: Wang Geng , Wang Heyang , Xu Bo , Yang Yuejin , Yang Zhiming , Li Hui , Zhang Zheng , Wang Haichang , Yang Lixia , Han Yaling 
Published: January 2017

Background: The safety and efficacy of the second‐generation biodegradable polymer Cobalt‐Chromium sirolimus‐eluting stent (EXCEL2) in daily clinical practice remains unknown. Additionally, to meet the China Food and Drug Administration requirements, we conducted an objective performance criterion study from the CREDIT II and CREDIT III trials.Methods: CREDIT II was a randomized trial comparing the EXCEL2 versus EXCEL stent in patients with up to 2 de novo coronary lesions. CREDIT III was a prospective, single‐arm study evaluating the efficacy and safety of EXCEL2 in broad types of de novo coronary artery lesions. This pooled analysis included patients in the CREDIT III and EXCEL2 arm of the CREDIT II trial. The primary outcome was 12‐month target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction (TV‐MI), and clinical indicated target lesion revascularization (CI‐TLR). The patient‐oriented composite endpoint (PoCE) of all‐cause death, all MI, or any revascularization was also analyzed.Results: A total of 833 patients were included, consisting of 625 in the CREDIT III trial and 208 in the EXCEL2 arm of the CREDIT II trial. Twelve‐month TLF occurred in 6.1% patients, cardiac death in 0.4%, TV‐MI in 5%, and CI‐TLR in 1.1%. Additionally, 64 (7.7%) PoCE and 3 probable late stent thromboses (0.4%) were recorded.Conclusion: EXCEL2 stent met the objective performance criterion on efficacy and safety with a low level of 12‐month TLF as well as stent thrombosis when treating patients with de novo coronary lesions. © 2017 Wiley Periodicals, Inc.
Predictors of long‐term outcomes after bypass grafting versus drug‐eluting stent implantation for left main or multivessel coronary artery disease
Authors: Chang Mineok , Lee Cheol Whan , Ahn Jung‐Min , Cavalcante Rafael , Sotomi Yohei , Onuma Yoshinobu , Han Minkyu , Park Seong‐Wook , Serruys Patrick W. , Park Seung‐Jung 
Published: January 2017

Background: We assessed predictors of long‐term outcomes after coronary artery bypass grafting (CABG) versus those after percutaneous coronary intervention (PCI) with drug‐eluting stents (DES) in 3,230 patients with left main or multivessel coronary artery disease (CAD).Methods and Results: Data were pooled from the BEST, PRECOMBAT, and SYNTAX trials. Age, chronic kidney disease, chronic obstructive lung disease, left ventricular dysfunction, and peripheral arterial disease (PAD) were common predictors of all‐cause mortality. Diabetes mellitus, previous myocardial infarction (MI), and SYNTAX score were independent predictors of all‐cause mortality in the PCI group, but not in the CABG group. In the CABG group, age was the only risk factor for MI; left ventricular dysfunction, hypertension, and PAD were risk factors for stroke. On the other hand, in the PCI group, incomplete revascularization and previous MI were risk factors for MI; age and previous stroke for stroke. In addition, chronic kidney disease significantly correlated with a composite outcome of death, MI, or stroke in the CABG group, and incomplete revascularization and previous MI in the PCI group.Conclusions: Simple clinical variables and SYNTAX score differentially predict long‐term outcomes after CABG versus those after PCI with DES for left main or multivessel CAD. Those predictors might help to guide the choice of revascularization strategy. © 2017 Wiley Periodicals, Inc.
Risk of contrast‐induced acute kidney injury in ST‐elevation myocardial infarction patients undergoing multi‐vessel intervention‐meta‐analysis of randomized trials and risk prediction modeling study using observational data
Authors: Chatterjee Saurav , Kundu Amartya , Mukherjee Debabrata , Sardar Partha , Mehran Roxana , Bashir Riyaz , Giri Jay , Abbott Jinnette D. 
Published: January 2017

ObjectivesAscertaining risk of contrast induced acute kidney injury (CI‐AKI) in ST‐segment elevation myocardial infarction (STEMI) patients undergoing multi‐vessel percutaneous coronary intervention (MV‐PCI).BackgroundComplete revascularization may improve outcomes in STEMI patients with multi‐vessel disease. However, a practice of MV‐PCI may be associated with a higher risk of CI‐AKI. We aimed to evaluate the risk of CI‐AKI in patients with STEMI and MV‐PCI and examine the accuracy of a validated risk score.MethodsWe searched PubMed, Cochrane Library, EMBASE, EBSCO, Web of Science, and CINAHL databases from inception through August 31, 2016 for randomized studies comparing CI‐AKI rates with MV‐PCI and infarct‐related artery (IRA) only PCI during index hospitalization. A random effects model was used to estimate the risk ratio (RR) and respective 95% confidence intervals (CI). We queried the Nationwide Inpatient Sample (NIS) to assess the ability of the Mehran risk score to accurately predict the incidence of CI‐AKI in patients undergoing MV‐PCI.ResultsFour randomized studies (N = 1,602) were included in the final analysis. The risk of CI‐AKI was low and no difference was observed with MV‐PCI (1.45%) compared with IRA‐only (1.94%) (RR 0.73, 95% CI 0.34‐1.57; P = 0.57). From 2009 to 2012, excluding shock, there were 11,454 MV‐PCI for STEMI patients in the NIS. The Mehran risk score accurately discriminated 78% of the patients who developed CI‐AKI in this cohort (c‐statistic of 0.78, P = 0.002).ConclusionsMV‐PCI in STEMI is not associated with a higher risk of CI‐AKI and the Mehran risk score can identify patients at higher risk for this complication. © 2017 Wiley Periodicals, Inc.
A novel stent inflation protocol improves long‐term outcomes compared with rapid inflation/deflation deployment method
Authors: Vallurupalli Srikanth , Kasula Srikanth , Kumar Agarwal Shiv , Pothineni Naga Venkata K. , Abualsuod Amjad , Hakeem Abdul , Ahmed Zubair , Uretsky Barry F. 
Published: January 2017

BackgroundHigh‐pressure inflation for coronary stent deployment is universally performed. However, the duration of inflation is variable and does not take into account differences in lesion compliance. We developed a standardized “pressure optimization protocol” (POP) using inflation pressure stability rather than an arbitrary inflation time or angiographic balloon appearance for stent deployment. Whether this approach improves long‐term outcomes is unknown.Methods and results792 patients who underwent PCI using either rapid inflation/deflation (n = 376) or POP (n = 416) between January 2009 and March 2014 were included. Exclusion criteria included PCI for acute myocardial infarction, in‐stent restenosis, chronic total occlusion, left main, and saphenous vein graft lesions. Primary endpoint was target vessel failure [TVF = combined end point of target vessel revascularization (TVR), myocardial infarction, and cardiac death]. Outcomes were analyzed in the entire cohort and in a propensity analysis.Stent implantation using POP with a median follow‐up of 1317 days was associated with lower TVF compared with rapid inflation/deflation (10.1 vs. 17.8%, P < 0.0001). This difference was driven by a decrease in TVR (7 vs. 10.6%, P = 0.0016) and cardiac death (2.9 vs. 5.8%, P = 0.017) while there was no difference in myocardial infarction (1 vs. 1.9%, P = 0.19). In the Cox regression model, deployment using POP was the only independent predictor of reduced TVF (HR 0.43; 0.29–0.64; P < 0.0001). In the propensity analysis (330 patients per group) TVF remained lower with POP vs. rapid inflation/deflation (10 vs. 18%, P < 0.0001).ConclusionsStent deployment using POP led to reduced TVF compared to rapid I/D. These results recommend this method to improve long‐term outcomes. © 2017 Wiley Periodicals, Inc.
Romiplostim therapy as a second‐line treatment before splenectomy for refractory immune thrombocytopenia in a cirrhotic patient with iatrogenic Cushing syndrome secondary to corticosteroids
Authors: Casanovas Taltavull Teresa , Peña‐Cala Maria Carmen 
Published: January 2017

Key Clinical MessageOur case report discusses the usefulness of administering romiplostim as a second‐line treatment before splenectomy in a cirrhotic patient with immune thrombocytopenia who developed corticosteroid‐induced Cushing's syndrome. Corticosteroids were tapered and consequently withdrawn. The patient made a full recovery postsplenectomy.
Well‐Defined Cesium Benzotriazolide as an Active Catalyst for Generating Disubstituted Ureas from Carbon Dioxide and Amines
Authors: Truong Cong Chien , Kim Jin , Lee Yunho , Kim Yong Jin 
Published: January 2017

AbstractThe front cover artwork for Issue 2/2017 is provided by a collaboration between Prof. Yong Jin Kim's group (KITECH), Prof. Yunho Lee's group (KAIST), and Korea University of Science and Technology (UST). The image shows that a robust and well‐defined Cesium Benzotriazolide can catalyze direct carboxylation of CO2 with various amines to produce corresponding disubstituted ureas in very high yield with highest TOF (344h−1) in the scope of carboxylation of amines. See the Communication itself at https://doi.org/10.1002/cctc.201601320.
Water‐Gas‐Shift over Metal‐Free Nanocrystalline Ceria: An Experimental and Theoretical Study
Authors: Guild Curtis J. , Vovchok Dimitriy , Kriz David A. , Bruix Albert , Hammer Bjørk , Llorca Jordi , Xu Wenqian , El‐Sawy Abdelhamid , Biswas Sourav , Rodriguez Jose A. , Senanayake Sanjaya D. , Suib Steven L. 
Published: January 2017

AbstractA tandem experimental and theoretical investigation of a mesoporous ceria catalyst reveals the properties of the metal oxide are conducive for activity typically ascribed to metals, suggesting reduced Ce3+ and oxygen vacancies are responsible for the inherent bi‐functionality of CO oxidation and dissociation of water required for facilitating the production of H2. The degree of reduction of the ceria, specifically the (1 0 0) face, is found to significantly influence the binding of reagents, suggesting reduced surfaces harbor the necessary reactive sites. The metal‐free catalysis of the reaction is significant for catalyst design considerations, and the suite of in situ analyses provides a comprehensive study of the dynamic nature of the high surface area catalyst system. This study postulates feasible improvements in catalytic activity may redirect the purpose of the water‐gas shift reaction from CO purification to primary hydrogen production.
Evaluation of Benzylamine Production via Reductive Amination of Benzaldehyde in a Slurry Reactor
Authors: Krupka Jiri , Dluhoš Libor , Mrózek Lech 
Published: January 2017

AbstractTechnological aspects of the reductive amination of benzaldehyde with ammonia in the absence of solvents are discussed. The reaction kinetics in a slurry reactor was experimentally studied in order to maximize the yield of benzylamine. Effects of reaction conditions and type of solid catalyst on the content of undesirable by‐products were investigated. In particular, benzyl alcohol and trimers of benzylimine, namely, hydrobenzamide and 2,4,5‐triphenyl‐4,5‐dihydro‐1H‐imidazole, were found as significant by‐products. The formation of poorly soluble high‐boiling trimers of benzylimine was minimized by semi‐batch arrangement of the process with continuous addition of benzaldehyde into the load of benzylamine, ammonia, and Raney‐Ni catalyst. Some important features of benzaldehyde amination, which make it less advantageous for benzylamine production compared to the benzonitrile hydrogenation, are described.
Multiphysics Model of a Fluorine Electrolysis Cell
Authors: Vukasin Julien , Crassous Isabelle , Morel Bertrand , Sanchez-Marcano José 
Published: January 2017

AbstractFluorine production results from the electrolysis of hydrogen fluoride‐based molten salts. This process involves several intimately related phenomena, including two‐phase flow, species transport, electrokinetics, and heat transfer. A multiphysics model was built in order to fully simulate this process and simulation results are compared to experimental data. The emphasis is placed on the process of solidification of the electrolyte on the cooling system and on mass transport close to the cathode. A complex link between bubble generation at the electrodes and species consumption has been highlighted.
Electrochemical Study of Selenocystine Reactivity and Reduction at Metallic Surfaces
Authors: Karnaukh Elizabeth A. , Walker Lindsey M. , Lynch Kelsey A. , Wiita Elizabeth G. , Buzzeo Marisa C. 
Published: January 2017

AbstractThe reduction of seleno‐L‐cystine is examined on gold and platinum electrodes in aqueous solution. The voltammetric behavior is indicative of a two‐step process, in which the metallic substrate is modified by the diselenide analyte prior to observation of diffusionally controlled, proton‐coupled electron transfer. X‐ray photoelectron spectroscopy confirms the presence of selenium on gold foil samples that have been reductively cycled in selenocystine solution. The selenium‐based surface modification, which is accessible through multiple preparation routes, can be removed by anodic stripping and fully restored through subsequent cycling. The described electrochemical approach allows for the analysis of redox‐active chalcogen‐containing species under physiologically relevant conditions.
Clathrate Structure Determination by Combining Crystal Structure Prediction with Computational and Experimental 129Xe NMR Spectroscopy
Authors: Selent Marcin , Nyman Jonas , Roukala Juho , Ilczyszyn Marek , Oilunkaniemi Raija , Bygrave Peter J. , Laitinen Risto , Jokisaari Jukka , Day Graeme M. , Lantto Perttu 
Published: January 2017

AbstractAn approach is presented for the structure determination of clathrates using NMR spectroscopy of enclathrated xenon to select from a set of predicted crystal structures. Crystal structure prediction methods have been used to generate an ensemble of putative structures of o‐ and m‐fluorophenol, whose previously unknown clathrate structures have been studied by 129Xe NMR spectroscopy. The high sensitivity of the 129Xe chemical shift tensor to the chemical environment and shape of the crystalline cavity makes it ideal as a probe for porous materials. The experimental powder NMR spectra can be used to directly confirm or reject hypothetical crystal structures generated by computational prediction, whose chemical shift tensors have been simulated using density functional theory. For each fluorophenol isomer one predicted crystal structure was found, whose measured and computed chemical shift tensors agree within experimental and computational error margins and these are thus proposed as the true fluorophenol xenon clathrate structures.
Directing the Self‐Assembly Behaviour of Porphyrin‐Based Supramolecular Systems
Authors: van der Weegen Rob , Teunissen Abraham J. P. , Meijer E. W. 
Published: January 2017

AbstractThe self‐assembly behaviour of a library of tetra‐amidated porphyrin molecules decorated with a variety of solubilizing wedges is investigated as dilute solutions in methylcyclohexane. Small changes in the solubilising wedge of the porphyrins resulted in different aggregated states, as evidenced by CD and UV/Vis absorption spectroscopy. The porphyrins form co‐facially stacked H‐aggregates, slip‐stacked J‐aggregates or a mixture of both. Detailed thermodynamic and kinetic analysis showed that in all cases the formation of J‐aggregates proceeds via an isodesmic mechanism whereas H‐aggregates are formed via a cooperative mechanism. It is shown that these aggregates assemble in a parallel pathway, in which both compete for the monomer, compared to a sequential pathway, in which one of the aggregates interconverts into the other. Interestingly, kinetic analysis of porphyrins that only form H‐aggregates in thermodynamic equilibrium revealed that the competing pathway towards J‐aggregates is operational in these systems as well. Our findings show that the balance between H‐ and J‐aggregates depends on remarkably small changes in the architecture of the solubilising wedges.
ON THE SPATIAL CORRELATION OF SEISMIC NOISE IN AN ATTENUATING MEDIUM
Authors: Kai‐Ming WANG , Lai‐Yu LU , Qing‐Hua LIU 
Published: January 2017

AbstractTraditionally, for the tomography based on the correlation of seismic noise, primarily the phase information of ambient noise correlation function (NCF) is used to extract the seismic velocity and anisotropy of the earth by travel time inversion. Researchers recently utilize the amplitude of NCF to extract the earth's attenuation. According to the theory, NCF is proportional to the first kind of zero‐order Bessel function in 2‐D elastic case, which is directly extended to dissipative medium by introducing an exponential attenuation coefficient. The attenuation of the structure is then obtained by comparing the observed data from NCF to the Bessel function multiplied by a decaying exponential term. The NCF, however, is affected by the azimuth averaging of ambient noise source distribution in attenuating media. This empirical and simple extension may not be used to extract reliable decay coefficient. In this paper, we study the theoretical expressions of NCF in frequency domain between two stations under different coordinate systems and accordingly different source distributions which are composed by superposition of plane waves. We show that the coherency expressions in dissipative media vary with coordinate systems. The expressions are different for different normalizing factors. The attenuation coefficient obtained by fitting the coherency J0(k0r)e−α(ω)r with the observed data is smaller than the real one.
THE ARGUMENTATION OF THE PROPERTIES OF BOREHOLE SYSTEM AT LINXIA STATION, CHINA
Authors: Xu‐Yan LIU , Jin‐Ling YANG , Chao‐Xian CHEN , Yu‐Mei GUAN , Guang CHEN , Wen‐Bo ZHAO , Ming‐Quan HONG 
Published: January 2017

Abstract2 years of four‐component borehole strain data and well water level data are preprocessed to remove trends and outliers at Linxia Station from 2013 to 2014. The sum of observation strain values of two orthogonal measurement lines is equivalent to surface strain of borehole, and two thirds of near‐ground surface strain is equal to volume strain. The volume strain can be obtained from four‐component borehole strain observation, and the properties of the borehole system can be demonstrated from time and frequencies domain based on the comparison between volume strain and underground well water level observation. Results show that the volume strain and well water level is highly negatively correlated in time domain. The sensitivity of borehole system is −0.1620 mm/10−9. Enlarging the proportion of two coordinates of volume strain and well water level observation curves of selected two months in the two year period, we found that the peak and valley of water level curve corresponds to the valley and peak of volume strain one by one, and the phase lag is very small. In the frequency domain, the monthly tidal factor and the phase lag of diurnal and semidiurnal wave groups of volume strain and well water level were obtained with the Venedikov tidal harmonic analysis method, and the sensitivity and phase lag of the borehole strain system were calculated out subsequently. Results show that the sensitivities of most wave groups are not only close to each other, but also close to the sensitivity of annually periodic change obtained from the time domain, while the errors of phase lag are large. Considering that the phase lag obtained by arctangent is easily influenced by calculation error, the phase lag close to zero from time domain should be better in reliability. The analysis in time and frequency domain showed that the response of well water level to volume strain is substantially linear time‐invariant. The borehole system of Linxia station basically meets the superposition, homogeneity and time invariance. Therefore, the borehole system at Linxia station is a linear time‐invariant system basically.