bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of First-Line Palliative Chemotherapy with Fluorouracil Plus Leucovorin, Oxaliplatin, and Docetaxel (FLOT) in HER2-Negative Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma: A Single-Institutional Real-World Experience from Eastern India
Authors: Chaudhuri Tamojit , Bankira Jaishree , Upadhyay Amitabh Kumar , Panda Rahul , Pandey Vanita , Mitra Sujata , Mukherjee Sopia 
Published: September 2024

Background Fluorouracil plus leucovorin, oxaliplatin, and docetaxel (FLOT) is one of the preferred perioperative chemotherapy regimens in locally advanced resectable gastric cancer (GC). Till date, there are very few published data from India, regarding the outcomes of this relatively well-tolerated biweekly triplet regimen as first-line palliative chemotherapy in metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma.
Materials and Methods In the present retrospective study, we evaluated the efficacy and safety of first-line FLOT regimen in Indian patients with HER2-negative metastatic adenocarcinoma of stomach or GEJ. The primary endpoint was overall survival (OS). Progression-free survival (PFS), overall response rate (ORR), and toxicity profile were taken as secondary endpoints.
Results Between January 2021 and June 2024, 88 patients were treated with FLOT. The median age was 52 years (range, 23–68); 69.3% were males and 37.5% of the patients had ≥ 3 metastatic disease sites involvement at baseline. Dose reductions due to toxicity were required in 25% of the patients. The ORR was 68.2%; median PFS and OS were 6.3 months (95% confidence interval [CI]: 5.3–7.4) and 12.5 months (95% CI: 11.3–14.2), respectively. The most frequent grade 3 to 4 adverse events were diarrhea (15.9%), fatigue (13.6%), and neutropenia (12.5%). Younger patients (aged < 55 years) had much less ≥ grade 3 diarrhea (7.5%, n = 4), compared with patients aged ≥ 55 years (28.6%, n = 10). There was one toxicity-related death.
Conclusion In the present study, biweekly FLOT regimen with primary prophylactic granulocyte colony-stimulating factor demonstrated encouraging efficacy with a favorable nongastrointestinal toxicity profile in Indian patients with HER2-negative metastatic gastric or GEJ adenocarcinoma. Clearly, this well-tolerated triplet regimen should be explored further through large prospective randomized trials in Asian patients.
An advanced double-phase stacking ensemble technique with active learning classifier: Toward reliable disruption prediction in Aditya tokamak
Authors: Muruganandham Priyanka , Jayaraman Sangeetha , Tahiliani Kumudni , Tanna Rakesh , Ghosh Joydeep , Pathak Surya K , Ramaiya Nilam 
Published: September 2024

Disruptions in tokamak nuclear reactors, where plasma confinement is suddenly lost, pose a serious threat to the reactor and its components. Classifying discharges as disruptive or non-disruptive is crucial for effective plasma operation and advanced prediction. Traditional disruption identification systems often struggle with noise, variability, and limited adaptability. To address these challenges, we propose an enhanced stacking generalization model called the “Double-Phase Stacking Technique” integrated with Pool-based Active Learning (DPST-PAL) for designing a robust classifier with minimal labor cost. This innovative approach improves classification accuracy and reliability using advanced data analysis techniques. We trained the DPST-PAL model on 162 diagnostic shots from the Aditya dataset, achieving a high accuracy of 98% and an F1-score of 0.99, surpassing conventional methods. Subsequently, the deep 1D convolutional predictor model is implemented and trained using the classified shots obtained from the DPST-PAL model to validate the reliability of the dataset, which is tested on 47 distinct shots. This model accurately predicts the disruptions 7–13 ms in advance with 93.6% accuracy and exhibited no premature alarms or misclassifications for our experimental shots.
Change of composition and surface plasmon resonance of Pd/Au core/shell nanoparticles triggered by CO adsorption
Authors: Ouvrard Aimeric , Alyabyeva Natalia , Zakaria Abdoul-Mouize , Yuan Keke , Dablemont Céline , Lazzari Rémi , Charra Fabrice , Bourguignon Bernard 
Published: September 2024

Controlling composition and plasmonic response of bimetallic nanoparticles (NPs) is of great relevance to tune their catalytic activity. Herein, we demonstrate reversible composition and plasmonic response transitions from a core/shell to a bimetallic alloyed palladium/gold NP triggered by CO adsorption and sample temperature. The use of self-organized growth on alumina template film allows scrutinizing the impact of core size and shell thickness onto NP geometry and plasmonic response. Topography, molecular adsorption, and plasmonic response are addressed by scanning tunneling microscopy, vibrational sum frequency generation (SFG) spectroscopy, and surface differential reflectance spectroscopy, respectively. Modeling CO dipolar interaction and optical reflectivity corroborate the experimental findings. We demonstrate that probing CO adsorption sites by SFG is a remarkably sensitive and relevant method to investigate shell composition and follow in real-time Pd atom migration between the core and the shell. Pd–Au alloying is limited to the first two monolayers of the shell and no plasmonic response is found, while for a thicker shell, a plasmonic response is observed, concomitant with a lower Pd concentration in the shell. Above 10−4 mbar, at room temperature, CO adsorption triggers the shell restructuration, forming a Pd–Au alloy that weakens the plasmonic response via Pd migration from the core to the shell. NP annealing at 550 K, after pumping CO, leads to the desorption of remaining CO and gives enough mobility for Pd to migrate back inside the core and recover a pure gold shell with its original plasmonic response. This work demonstrates that surface stoichiometry and plasmonic response can be tuned by using CO adsorption and NP annealing.
Ru/MgO-catalysed selective aerobic oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid
Authors: Lokhande Priya , Dhepe Paresh L. , Wilson Karen , Lee Adam F. 
Published: September 2024

Biomass valorisation through the selective oxidation of carbohydrate and lipid derivatives offers access to an array of platform chemicals through energy- and atom-efficient catalytic processes. Supported metal nanoparticles are promising catalysts for the aerobic selective oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA), but typically require strong liquid base to achieve high selectivity. Here, we explore the utility of MgO as a solid base support for the Ru-catalysed aerobic oxidation of HMF, obtaining 68% FDCA yield at 160°C and 1.5 MPa of O2 using <1 mol-% metal.
High chytrid prevalence and infection intensities in tadpoles of Mixophyes fleayi
Authors: Hollanders Matthijs , Grogan Laura F. , McCallum Hamish I. , Newell David A. 
Published: September 2024

Context The amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd) has caused catastrophic biodiversity loss globally, but species and life stages within species respond differently to the pathogen. Although tadpoles are often reported to be less vulnerable to disease, they can constitute important infection reservoirs in ecosystems. Aims We aimed to describe Bd infection patterns of a long-lived tadpole in a species where post-metamorphic animals appear to exhibit limited mortality as a result of chytridiomycosis. We further investigated how oral dekeratinisation can be used as an indicator of infection. Methods We conducted surveys of tadpoles of Mixophyes fleayi (Fleay’s barred frog) over 2 years, at two rainforest streams on the east coast of Australia, to assess patterns in Bd infection prevalence and intensity. We developed an integrated hierarchical model propagating pathogen-detection errors and incorporating how Bd infections affect oral dekeratinisation. Key results We found that Bd infection prevalence was strongly associated with lower temperatures and a larger body size, consistent with Bd optimal thermal range and a cumulative risk of exposure for tadpoles. The individual probability of a tadpole being infected with Bd was estimated to be 0.58 [95% HPDI: 0.432, 0.713], the odds of which were approximately eight times greater than for adults at the same sites. Tadpoles infected with Bd were 113 [29, 293] times more likely to have oral dekeratinisation than were uninfected tadpoles, where uninfected individuals were estimated to have a 0.05 [95% HPDI: 0.011, 0.11] probability of having mouthpart loss. Conclusions Our results showed that M. fleayi tadpoles are more likely to be infected with Bd than are adults, suggesting that tadpoles could contribute to Bd maintenance in streams. We further showed that sites can be rapidly assessed for Bd by visually checking for oral dekeratinisation. Implications Long-lived tadpoles, in general, may contribute to Bd maintenance in ecosystems. We suggest continued exploration of Bd immunocompetence across amphibian life stages to further understand the vastly different infection patterns.
Assessment of a system for gait parameter extraction and individual feature classification using artificial neural networks and a low-cost accelerometer
Authors: López-Tapia Andrea , Reyes-Barranca Mario Alfredo , Abarca-Jiménez Griselda Stephany , Sánchez-Márquez Luis , Flores-Nava Luis Martín 
Published: September 2024

Abstract
A system designed for monitoring the footsteps of a person is presented, aimed at determining characteristic and statistical parameters of the individual’s gait. This non-invasive approach utilizes a low-cost commercial capacitive accelerometer to sense the vibrations caused by each step as an individual walks on the floor. The system captures signals from the accelerometer, which are then processed to obtain different signal parameters (such as step duration, cadence, stride duration, kurtosis, skewness, etc), providing information about each subject under study. The collected information is stored in a database, and artificial neural networks are employed in this report to classify types or styles of walking, as well as to identify the person’s gender, age, and body mass index. With the implementation of classifiers, physical characteristics can be grouped, potentially focusing on diagnoses or identifications based on specific data. Finally, the results obtained from tests performed on 30 volunteers are presented, verifying the accelerometer’s performance and the algorithm’s effectiveness, with accuracy percentages up to 99.2% for classification. The results show a high level of coincidence and are promising for the future improvement of the system.
Effect of anisotropy and length dispersity on electrical and optical properties of nanowire network based transparent electrodes: a computational study
Authors: Bharti Yugam , Malik Vikas , Bhandari Preeti , Aggarwal Shruti 
Published: September 2024

Abstract
We have studied the impact of nanowire alignment and measurement direction at the percolation threshold on the effective resistance (R) of two-dimensional (2D) films. This helps us to analyze the effect of anisotropy on the conductivity and transmittance of the nanowire-based network characterized by the disorder parameter (s). These optoelectronic properties are determined for systems with monodisperse and bimodal length distribution (a combination of two fixed lengths of nanowires). The 2D systems simulated using our computational approach are assumed to be transparent and conductive in which percolative transport is the primary conduction mechanism. We obtain our results numerically using a computational and geometrical approach, i.e. a Discrete (grid) method that is advantageous in algorithm speed. For a particular disorder parameter s, the conductivity and transmittance increase as the length fraction (LF) increases for the bimodal distribution of the length of nanowires in networks. We have observed the maximum conductivity when the nanowires are highly aligned along the measurement direction of percolation, in contrast to the isotropic arrangement of nanowires. Significantly, alignment introduced in nanowires leads to a higher percolation threshold which leads to a decrease in the transmittance of the network. We show that the resistivity of the monodisperse network in the direction parallel (perpendicular) to the alignment decreases (increases) with the disorder parameter and scales as s (s
2). This scaling holds true for the bimodal distribution of nanowires as well. For a particular LF, the electrical anisotropy increases with s. The anisotropy is maximum for nearly aligned nanowires in a bimodal network with the highest proportion of the longest wire considered. For the maximally aligned wires and highest LF, we obtained an approximately 50

%

enhancement in the figure of merit, denoted by φ. Hence, incorporating longer-length wires and increasing the alignment in nanowire networks can increase the conductivity, anisotropy, and figure of merit which may benefit a vast range of applications.
Near-field terahertz electro-optical imaging based on a polarization image sensor
Authors: Guiramand L , Lafrenière-Greig J , Ropagnol X , Blanchard F 
Published: September 2024

Abstract
This paper presents a hyperspectral microscopy system that offers two-dimensional (2D) measurement of the spectral phase and amplitude information of terahertz (THz) radiation without the need for raster scanning. To achieve this, a new THz imaging method is introduced, wherein the distribution of the THz electric field is spatially measured using the electro-optic effect with a commercial polarization image sensor. This method enables the direct measurement of polarization components, eliminating the need for the polarization optics usually required in conventional electro-optical imaging. The performance of this imaging method is compared with a conventional 2D imaging system based on a standard visible camera. Finally, the sub-wavelength resolution capabilities of this new sensor are demonstrated by imaging a sample in the near field.
Reliable Adder Design: A Review
Authors: Akbar M A , Abubakar A , Bermak A 
Published: September 2024

Abstract
With the increasing complexity of system-on-chip designs, the probability of having soft-errors is increasing sharply. Since, adder is one of the essential elements present in almost every digital system, therefore, by making adder fault tolerant will create a potential impact on wide variety of digital applications. In this paper, a review has been presented to demonstrate the previously proposed solutions for fault tolerant adder design. In addition to the self-checking approaches, this paper also presented self-repairing techniques. A comparative analysis in terms of complexity, fault coverage and area-overhead has also been presented to conclude the performance of each covered approach.
Research on the Application of improved AMCL Algorithm in Robot Obstacle Avoidance in Logistics Sorting Scene
Authors: Shang Gongyu , Gong Gu , Hu Xiaoting , Liu Xintong , Zhu Hua 
Published: September 2024

Abstract
Compared with the normal scenes, the positions of obstacles, delivery boxes and sorting stations in the logistics sorting scene are relatively fixed, what’s more, the number of static obstacles in the logistics sorting scene is large. It requires higher navigation accuracy and pose adjustment of the robot. The author proposes an Adaptive Monte Carlo Localization (AMCL) algorithm that integrates the Dynamic Window Approach (DWA) algorithm to improve the accuracy and efficiency of robots in real-time positioning, navigation in static indoor environments, and obstacle avoidance efficiency. Using this method, the data collection of lidar sensor are optimized, reducing positioning calculation. By adjusting the parameters’ value, the adaptive positioning accuracy and real-time positioning rate of the logistics robot are improved. The experimental results show that the Adaptive Monte Carlo Localization integrated with Dynamic Window Approach algorithm is about 13.682 % higher than the normal Adaptive Monte Carlo Localization algorithm in the obstacle avoidance rate, which effectively makes the number of particles collected by lidar more standardized and rational.
Ghost imaging Lidar: principle, progress and prospect
Authors: Gong Wenlin , Han Shensheng 
Published: September 2024

Abstract
Ghost imaging (GI), as a computational imaging technology, can staringly obtain the target’s image by computing the second-order correlation function between the intensity of modulation field and the target’s echo signal recorded by a single-pixel detector. Since GI with classical light source was experimentally demonstrated, GI Lidar has been considered to be one of the best application prospects in GI direction and become a research hotspot. With in-depth study and development of GI Lidar in recent years, GI Lidar has achieved significant progress and is expected to be applied in the near future. In this paper, we try to sketch the basic principles and superiorities of two kinds of GI Lidar. Next, with respect to the application of long-range, high-resolution, and high-speed moving target detection and recognition, we introduce the development progress of narrow-pulsed GI Lidar and long-pulsed GI Lidar via heterodyne detection. Finally, the key problems and prospect of GI Lidar are also discussed.
Rejecting, Sifting, Reshaping, and Ordering, 1875–1876
Authors: Korstvedt Benjamin M 
Published: September 2024

Abstract
Bruckner began to revise the Fourth Symphony almost immediately after he completed the score in 1874. First, he added additional layers of imitative counterpoint to certain passages. Then, in anticipation of a possible performance in 1876, he made two additional sets of revisions. These have never before been brought to light. One was a series of revisions to phrase structures based on his systematic analysis of the work, which made use of his so-called metrical numbers. The other was a series of adjustments to orchestration and dynamic markings in passages that he came to feel he had “harmed” with an excess of contrapuntal imitation.
The Music of the Third Version
Authors: Korstvedt Benjamin M 
Published: September 2024

Abstract
The musical differences between the second version and the third version of the Fourth may be less fundamental than those between the first and the second versions; nevertheless they are significant and demand careful consideration. By and large, the fundamental musical content is not substantially altered, but throughout the score, changes exist in the orchestration, including dynamic balances, and in tempo and other performance markings. This chapter explores these attributes of the third version, as well as Bruckner’s role in their creation. The pertinence of these changes to successful performance of the work is emphasized. Finally, the chapter surveys differing opinions about the musical value of this version offered by scholars, critics, composers, and conductors.
The Fourth in Performance, a Historical Sketch
Authors: Korstvedt Benjamin M 
Published: September 2024

Abstract
In the early twentieth century, Bruckner’s Fourth Symphony gained a secure place in the orchestral repertoire. This chapter considers how it has been performed over the ensuing decades. It begins by discussing Bruckner’s statements about the performance of his symphonies. Tempos and tempo modifications emerge as a point of central concern for Bruckner—and for later generations of performers as well. Wagner’s ideas about the need for tempos that respond fluidly to the Melos of the music influenced the first generation of Bruckner conductors, starting with Ferdinand Löwe and Franz and Josef Schalk. In the 1920s and 1930s, reactions against this style arose. The chapter reviews how these changing approaches developed, in part by surveying how tempo is handled in recordings from the 1930s onward. Finally, the chapter examines how musical meaning may be colored by performance styles.
Systematic Review and Meta-Analysis of Diagnostic and Predictive Accuracy of the Clinical Frailty Scale in Older Adults in Emergency Department
Authors: Koay Wen Jie , Leahy Aoife , Barry Louise , Condon Jennifer , Egan Aisling , Prendiville Tadhg , O'Loughlin Monica , Gabr Ahmed , Mohamed Abdirahman Sheikh , Peters Catherine , Quinn Colin , Conroy Simon , O'Connor Margaret , Galvin Rose 
Published: September 2024

Abstract

Background
Older adults attending the Emergency Department (ED) should be assessed using a frailty screening tool as older adults living with frailty are more likely to experience adverse outcomes. The Clinical Frailty Scale (CFS) is commonly used for this. This systematic review and meta-analysis synthesise the literature studying predictive accuracy of the CFS for identifying older adults at risk of adverse outcomes following ED visit, and the diagnostic accuracy of the CFS for identifying older adults living with frailty attending the ED.

Methods
A systematic literature search was conducted to identify studies that attempted to validate the diagnostic and predictive accuracy of the CFS for older adults in the ED setting. The population included were older adults over 65 years of age who presented to the ED with undifferentiated medical complaints. All included studies assessed the diagnostic accuracy of the CFS in comparison to a reference standard: Frailty Index, Comprehensive Geriatric Assessment or Frailty Phenotype. The adverse outcomes included were mortality, falls, functional decline, ED re-attendance, hospital admission, length of stay and institutionalisation.

Results
Nineteen studies were included with sixteen individual cohorts. All studies investigated predictive accuracy and four studies assessed diagnostic accuracy for the CFS. The CFS showed predictive accuracy for the outcomes of mortality at all timepoints (RR 3.05 (CI 2.22, 4.21)), ED re-attendance at 30 days (RR 1.47 (CI 1.12, 1.94)), hospital admission at index visit (RR 1.72 (CI 1.26, 2.34) and institutionalisation (RR 3.63 (CI 1.41, 9.36). The studies included had an overall low risk of bias.

Conclusion
The CFS successfully identifies those at risk of adverse outcomes of death, ED revisit, hospitalisation and institutionalisation. However, there is a paucity of studies which assess its diagnostic accuracy. Overall, it is a useful screening tool to identify those who may benefit from comprehensive multidisciplinary assessment in the ED setting.