bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers to women’s representation in academic excellence and positions of power
Authors: Yousaf Rizwana , Schmiede Rudi 
Published: January 2017

AbstractNearly for half a century women’s advancement in the workplace has been in a debate. Women’s under-represented in higher education institutions and universities across the globe, and especially in the most powerful or influential posts, is well established. Despite gender equality commitments and women’s educational attainment, still, they are underrepresented. Regions and countries may vary in term of culture, achievements and development, but barriers for women’s representation in academia are surprisingly similar in many regions. It is found that there are several barriers which women might be experiencing in academia ranging from personal, organizational to societal.
HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1
Authors: Latasiewicz Joanna , Artz Annette , Jing Ding , Blanco Mariana Pacheco , Currie Silke M , Avila Martha Velázquez , Schnoor Michael , Vestweber Dietmar 
Published: January 2017

Abstract
Neutrophil extravasation is a critical step of the innate immune system’s response to inflammation. This multistep process is tightly regulated by adhesion and signaling molecules in the endothelium and neutrophils. Activation of the β2 integrin LFA-1 is critical for adhesion of leukocytes to postcapillary venules. This step requires coordinated activation of signaling pathways in chemokine-stimulated neutrophils, including GTPase activation and cytoskeletal remodeling, leading to conformational changes in LFA-1. Hematopoietic cell-specific lyn substrate 1 (HS1) is a cortactin-related and leukocyte-specific actin-binding protein (ABP) that regulates several processes in various immune cells. It has been shown in vitro that HS1 is important for neutrophil chemotaxis and transendothelial migration of NK cells, but its role in neutrophil extravasation in vivo has not been investigated yet. Intravital microscopy of CXCL1-stimulated cremaster venules revealed an increased rolling velocity and reduced neutrophil adhesion and transmigration in HS1 knockout (KO) mice. CXCL1-induced rapid neutrophil arrest in vivo and adhesion under flow conditions in vitro were also reduced significantly. Whereas random motility of neutrophils was unaffected, chemotaxis toward a CXCL1 gradient was reduced in the absence of HS1. Further analysis of the underlying mechanisms demonstrated that HS1 controls CXCL1-induced activation of the small GTPases Ras-related C3 botulinum toxin substrate 1 (Rac1) and Ras-related protein 1 (Rap1), thus supporting LFA-1-mediated neutrophil adhesion. Importantly, with the use of Rac1 KO neutrophils, we could show that Rac1 acts upstream of Rap1. Our results establish HS1 as an important regulator of proper Rac1 and Rap1 activation and neutrophil extravasation.
IKKα regulates human keratinocyte migration through surveillance of the redox environment
Authors: Lisse Thomas S. , Rieger Sandra 
Published: January 2017

ABSTRACT
Although the functions of H2O2 in epidermal wound repair are conserved throughout evolution, the underlying signaling mechanisms are largely unknown. In this study we used human keratinocytes (HEK001) to investigate H2O2-dependent wound repair mechanisms. Scratch wounding led to H2O2 production in two or three cell layers at the wound margin within ∼30 min and subsequent cysteine modification of proteins via sulfenylation. Intriguingly, exogenous H2O2 treatment resulted in preferential sulfenylation of keratinocytes that adopted a migratory phenotype and detached from neighboring cells, suggesting that one of the primary functions of H2O2 is to stimulate signaling factors involved in cell migration. Based on previous findings that revealed epidermal growth factor receptor (EGFR) involvement in H2O2-dependent cell migration, we analyzed oxidation of a candidate upstream target, the inhibitor of κB kinase α (IKKα; encoded by CHUK), as a mechanism of action. We show that IKKα is sulfenylated at a conserved cysteine residue in the kinase domain, which correlates with de-repression of EGF promoter activity and increased EGF expression. Thus, this indicates that IKKα promotes migration through dynamic interactions with the EGF promoter depending on the redox state within cells.
Nucleoside-diphosphatase of cestode Bothriocephalus scorpii (Cestoda: Bothriocephalidae)
Authors: Буренина  , Burenina E. 
Published: January 2017

Objective of research: To study the activities and properties of nucleoside- diphosphatase (NDPase) in cestode Bothriocephalus scorpii.
Materials and methods: Cestodes were homogenized with 10 vol. of extraction medium. NDPase was detected in mitochondria and microsomes with substrates (IDP, GDP, UDP). Inorganic phosphorus was determined by the method of Kochetov (1980). The effects of 10 anthelmintic drugs on the activity of NDPase were studied.
Results and discussion: It was found that the mitochondrial and microsomal fractions of cestodes B. scorpii have nucleoside diphosphatase activity. The activity of nucleoside diphosphatase depends on substrates and Mg2+ ions. The impact of various effectors and ions (Ca2+, Mn2+, Zn2+) on enzyme activity was determined. Effects of 10 anthelmintic drugs on activity of nucleoside diphosphatase were studied. The anthelmintics Bitionol and Trichlorophen have been proved effective.
Induction of plant resistance to nematodes sedentary biogenic elicitors
Authors: Удалова  , Udalova Zh. , Зиновьева  , Zinoveva S. 
Published: January 2017

Objective of research: to study the mechanisms of induced tomato plant resistance to rootknot nematode Meloidogyne incognita and potato to cyst nematode Globodera rostochiensis.
Materials and methods: The biogenic elicitors — chitosan and signal molecules — SA, JA for the modulation of immune plant responses were used. In experiment 1, tubers of potato cultivars Istrinskii (PCN-susceptibility) and Krinitsa (PCN-resistant), were treated with aqueous solutions of the immunomodulators at the specified concentrations. A low molecular weight soluble chitosan and acetylation degree of 15% and signal molecule — SA was used as an elicitor. In experiment 2, system tomato M. incognia was studied. Water solutions of chitosan, signal molecules: SA, JA were used for treatment of tomato seeds for 2 h and then the seeds were planted in sterile soil. The control plants were treated with water. Cultivation of plants was carried out by the standard technique. Plants were maintained in a greenhouse long enough for the nematodes to complete their life cycle. Development of nematodes in the processed plants estimated on morphophysiological and population characteristics. Biochemical indicators of roots and leaves of tomatoes estimated for 14 days after infection of plants. Previously identified major biochemical indicators of the plants in the genome that contain genes that determine the resistance of plants.
The effects of biogenic elicitors on plant resistance were also evaluated by some metabolic changes related to natural plant resistance to tomato and potato to plant nematodes. These indicators were studied in clarifying mechanisms of induced resistance.
Results and discussion: Biogenic elicitors induce systemic resistance of plants to plant parasitic nematodes — Meloidogyne incognita and Globodera rostochiensis (decrease in the parasitic invasion of the roots; an inhibition of the vital activity of the parasite; a decrease in fertility and the amount of agents sources (larvae and eggs) capable of infecting the plants).
The addition of signal molecules (salicylic and jasmonic acid) to elicitors increased their activity as immunomodulators. In present investigation, the mechanisms of induced plant resistance nematode were studied. The data obtained suggest that the mechanisms natural and induced by biogenic elicitors tomato resistance to the nematode have the same origin. These features meet all requirements of the new generation of methods of plant protection and the use of biogenic elicitors to raise plant resistance to parasitic nematodes may be promising.
Hallux rigidus
Authors: Ho Bryant , Baumhauer Judith 
Published: January 2017

An estimated 40% of the US population have foot problems. Of all patients aged over 50 years, 2.5% report degenerative arthritis of the first metatarsophalangeal (MTP) joint, termed ‘hallux rigidus’. First MTP osteoarthritis is the most common arthritic condition in the foot. Progression of great toe arthritis is associated with pain and loss of motion. Non-surgical intervention begins with shoe modifications and orthotics designed to limit MTP motion. In patients with mild arthritis, operative procedures focus on removing excess osteophytes (cheilectomy) to prevent dorsal impingement with or without a concomitant osteotomy (Moberg) to improve or shift range of motion into a less painful arc. In patients with more advanced arthritis, operative management has centred on arthrodesis of the first MTP joint. A recent Level 1 study shows excellent function and pain relief with a small hydrogel hemi-implant into the metatarsal head Multiple joint-sparing procedures such as joint arthroplasty or resurfacing have been described with inconsistent results.Cite this article: EFORT Open Rev 2017;2:13–20. DOI: 10.1302/2058-5241.2.160031
Hubungan Hygiene Sanitasi dengan Kualitas Bakteriologis Depot Air Minum (DAM) di Kabupaten Balangan
Authors: Suriadi Suriadi , Husaini Husaini , Marlinae Lenie 
Published: January 2017

Drinking water depo (DAM) continues to increase in line with the dynamics of the community needs to drinking water. DAM water contamination can be caused by factor sanitation hygiene of the DAM. This research aims to determine of the relationshipbetweensanitary hygiene andbacteriological quality in the DAM. It is observational using cross sectional design. Thepopulation of this research was over all depo of drinking water in Balangan, while sample was takenby purposive sampling which has been determined based on inclusion and exclusion criteria. The research variables are location, building, production equipment, production process, sanitary facilities and bacteriological quality. The instrument used in this research was the observation sheets and laboratory tests. Data was analyzed by univariate, bivariate analysis using chi square test. The results showed from 41 DAM, there are 13 (31.7%) less sanitary conditions of hygiene, 17 (41.5%) is enough and 11 (26.8%) good, then quality of bakteriologis are 30 (73%) eligible and 11 (27%) not eligible. There is no relationship betwen locations (p = 0.698) and bacteriological quality, no relationship building (p=0.840) with the bacteriological quality, no relationship of production equipment (p=0.618) with the bacteriological quality, no relationship of production proces (p=0.986) with the bacteriological quality and there is no relationship of sanitation facilities (p=0.515) with bacteriological quality.The most of sanitation hygiene condition is notrelationshipto bacteriological quality of reffil drinking water depo.
Distribusi Kasus Leptospirosis di Kabupaten Demak Jawa Tengah
Authors: Kuswati Kuswati 
Published: January 2017

Title: Distribution of Leptospiosis Incidence in Demak District, Central JavaBackground: Leptospirosis is zoonotic disease caused by Leptospira bacteria and transmitted to human through contact with animal urine into contaminated environment. Demak District is one of the endemic area in Central - Java. The number of cases is fluctuative over the year 2011-2016 with the peak of 20 cases in 2011, and It decreased at low number in 2016. Many factors may contributed such as water puddle, rat, and behaviour. Nowdays,the information about the distribution and spreading of cases was lacking. The purpose of this study was to describe the leptospiroses incidence based on the epidemiological variable and spatially in Demak District.Method: It was an observational research using cross sectional design. The subjects were 89 cases over the year 2011-2016. The variables studied consisted of epidemiological variabels (man, place, and time), physical and biological environment factors, and behaviour aspects. Interviews and observation were conducted as the data collection techniques.The collected data would be analysed descriptively and spatially.Result: The results of this research showed that the lepstospirosis incidence was –suffered more by male (66%) compared to female. Most of them (67,4%) were farmers. The peak of leptospirosis incidence occured in 2011. The existence of water puddle around the house, and drainage functioning as the media where the rat died. There were rats in the house where the cases occured (98,7%). Most of the subjects (66,7%) stated that they did their activities everyday in bare foot. Spatial analysis showed that Mranggen and Karangawen sub district had high numbers of leptospirosis cases.Conclusion: Most of the leptispirosis cases were suffered more by male compared to female and the subjects worked as farmers. Mranggen and Karangnawen were two districts with high incidence of leptospirosis relatively. These areas held a history as flooding areas in previous time.
Coupled Versus Uncoupled Blow-Up Rates in Cooperative n-Species Logistic Systems
Authors: López-Gómez Julián , Maire Luis 
Published: January 2017

Abstract
This paper ascertains the exact boundary blow-up rates of the large positive solutions of a class of cooperative logistic systems involving n species in a general domain of

ℝ
N

{\mathbb{R}^{N}}

of class

𝒞

2
+
ν

{\mathcal{C}^{2+\nu}}

,

0
<
ν
<
1

{0<\nu<1}

. The problem models a population divided in groups whose individuals compete with those of the same group, while simultaneously they cooperate with the members of the remaining groups. Our main result provides with the exact blow-up rates along the edges of Ω from the values of the blow-up rates of the underlying uncoupled system. Rather astonishingly, these blow-up rates are independent of the strength of the cooperative effects, which play a secondary role in the analysis carried out in this paper. No previous result of this nature is available in the specialized literature for more than

n
=
2

{n=2}

species.
Determination of the Starting Point in Time Series for Trend Detection Based on Overlapping Trend
Authors: Xuedong Gao , Kan Gu 
Published: January 2017

Abstract
The traditional time series studies consider the time series as a whole while carrying on the trend detection; therefore not enough attention is paid to the stage characteristic. On the other hand, the piecewise linear fitting type methods for trend detection are lacking consideration of the possibility that the same node belongs to multiple trends. The above two methods are affected by the start position of the sequence. In this paper, the concept of overlapping trend is proposed, and the definition of milestone nodes is given on its base; these way not only the recognition of overlapping trend is realized, but also the negative influence of the starting point of sequence is effectively reduced. The experimental results show that the computational accuracy is not affected by the improved algorithm and the time cost is greatly reduced when dealing with the processing tasks on dynamic growing data sequence.
Low Cost Locating Method of Wireless Sensor Network in Precision Agriculture
Authors: Yu Cunjiang 
Published: January 2017

Abstract
The wireless sensor network covers more scale with more sensor nodes for larger scale agriculture. The article describes improvement of DV-Hop Algorithm to locate the nodes with quadrilateral range positioning method, so that the difficulty of dilatation method in agriculture actual application to be solved. The analog test for the algorithm is conducted and is mainly developed for the average locating error with illustration and discussion on the proportion relations of average error, average connectivity and anchor nodes. According to the analog results, the algorithm obtains better effect on the average locating error, which improves the accuracy of the algorithm.
Head Pose Estimation Based on Robust Convolutional Neural Network
Authors: Bao Jiao , Ye Mao 
Published: January 2017

Abstract
Head pose estimation plays an important role in face recognition. However, it faces vast challenges on account of the initialization, facial feature points’ location accuracy and so on. Inspired by the observation that head pose angles change smoothly and continuously, we present a method based on a robust convolutional neural network for head pose estimation. The proposed network architecture consists of three levels and each level has three convolutional neural networks. The first level is a global one; it predicts the head pose quickly as a preliminary estimation. The following two levels are local ones; they refine the estimation achieved from the previous level step by step. Higher and higher resolution image with different input regions are taken as input in our network. At last, a multi-level regression is employed to combine the estimations from each level. The whole process is conducted in a cascade way to improve the head pose estimation performance directly with three angles together. We perform large experiments on nine challenging benchmark datasets. The experimental results demonstrate that our method performs better than the compared methods.
Depth Data Reconstruction Based on Gaussian Mixture Model
Authors: Li Zhe , Ma Chen , Zhang Tian-Fan 
Published: January 2017

Abstract
Depth data is an effective tool to locate the intelligent agent in space because it accurately records the 3D geometry information on the surface of the scanned object, and is not affected by factors like shadow and light. However, if there are many planes in the work scene, it is difficult to identify objects and process the resulting huge amount of data. In view of this problem and targeted at object calibration, this paper puts forward a depth data calibration method based on Gauss mixture model. The method converts the depth data to point cloud, filters the noise and collects samples, which effectively reduces the computational load in the following steps. Besides, the authors cluster the point cloud vector with the Gaussian mixture model, and obtain the target and background planes by using the random sampling consensus algorithm to fit the planes. The combination of target Region Of Intelligent agent (ROI) and point cloud significantly reduces the computational load and improves the computing speed. The effect and accuracy of the algorithm is verified by the test of the actual object.
Application of Improved Recommendation System Based on Spark Platform in Big Data Analysis
Authors: Xie Li , Zhou Wenbo , Li Yaosen 
Published: January 2017

Abstract
In the era of big data, people have to face information filtration problem. For those cases when users do not or cannot express their demands clearly, recommender system can analyse user’s information more proactive and intelligent to filter out something users want. This property makes recommender system play a very important role in the field of e-commerce, social network and so on. The collaborative filtering recommendation algorithm based on Alternating Least Squares (ALS) is one of common algorithms using matrix factorization technique of recommendation system. In this paper, we design the parallel implementation process of the recommendation algorithm based on Spark platform and the related technology research of recommendation systems. Because of the shortcomings of the recommendation algorithm based on ALS model, a new loss function is designed. Before the model is trained, the similarity information of users and items is fused. The experimental results show that the performance of the proposed algorithm is better than that of algorithm based on ALS.
Destination Networks as a Tool for Minimizing the Risk and Improving the Performance of a Destination
Authors: Holešinská Andrea , Bobková Markéta 
Published: January 2017

Abstract
The management of a tourist destination in the form of networks is considered to be one of the possible approaches to destination governance structures. The concept of destination governance is based on the cooperation between actors from the public and private sectors. It is known that public–private relationships built on trust, joint risk taking and based on informal structures have a positive impact on the level of growth at a tourist destination. The aim of this paper is to quantify to what extent each of the determinants of the DMO success participate in the total destination performance, and thus point out the factors of a potential risk.
The main objective of this paper is the cooperation between the destination management organization (DMO), public sector and entrepreneurs providing tourism services. The data collection was achieved by conducting in-depth interviews and structured questionnaires. The analysed data identify the factors of successful mutual cooperation that are used as inputs for further modelling. The contribution of the paper lies in the application of the total quality management concept methodology to identify the share of each factor/determinant in the DMO performance.
Attitude of Local Dwellers towards Ecotourism in the Okomu National Park, Edo State Nigeria
Authors: Digun-Aweto Oghenetejiri , Fawole Ogbanero Pipy , Ayodele Ibukun Augustine 
Published: January 2017

Abstract
Ensuring local community support for national parks is viewed as a paramount ingredient for conservation and sustainability. This is advocated for the park to meet its conservation goals. The Okomu National Park (ONP), Edo State, Nigeria, is one of such protected areas of lush green rain forest requiring conservation.
This study examined the local inhabitants’ attitudes view on ecotourism towards the national park and its importance to natural resource conservation in ONP. The park is home to the endangered white throated monkey and the forest elephant.
Data were collected on the basis of questionnaires, distributed among eight communities, which have a direct relationship with the park. A total of 338 questionnaires were distributed in eight communities around the park. The results of the survey revealed positive attitudes towards ecotourism in the area of the conservation of wildlife (69%). In addition, 71% of respondents thought that ecotourism helped in saving their forests.
A positive relationship between benefits derived, educational level, religion, family size and being a native of the area and attitudes were established, suggesting that these significant factors play an important role in influencing local support for conservation. Among the major limitations the local inhabitants listed their exclusion as copartners in the management of the park and the prohibitive laws that deprive the locals of gathering non-timber forest products, which negatively affects their livelihood. ONP conservationists should work at improving their relationship with the host communities, and include them in management activities. Only then can development and conservation goals be achieved.