bluuebunny/crossref_metadata_2025_split huggingface dataset:
From seafloor spreading to obduction: Jurassic–Cretaceous evolution of the northern branch of the Neotethys in the Northeastern Anatolian and Lesser Caucasus regions
Authors: Hässig M. , Rolland Y. , Sosson M. 
Published: December 2015

Abstract
We present arguments for an innovative tectonic set-up just prior to the Northern Neotethys obduction event in the NE Anatolian and Lesser Caucasus area. Along the Northern Neotethyan suture (the Ankara–Erzincan–Amasia–Sevan–Akera suture zone), relicts of the northern branch of the Neotethys oceanic domain outcrop as preserved unmetamorphosed slivers obducted over the northern edge of the South Armenian Block (SAB) and Taurides–Anatolides Platform (TAP) margins. Recent studies have shown that the ophiolitic bodies are formed of similar lithologies of Middle Jurassic age, all bearing mid-ocean ridge basalt chemical compositions enriched in large ion lithophile elements. This extensive database supports a model in which these ophiolites are derived from a single obducted nappe. This model is supported by the metamorphic pressure–temperature–time paths of the sole lithologies under the outcrops of the suture zone ophiolites. Palaeontological dating of sediment deposits directly under or sealing the obduction contact also support this model by temporally linking the emplacement of distant ophiolite outcrops. General emplacement during early Late Cretaceous time has been determined. A south-dipping subduction under the SAB shortly predating obduction has recently been proposed from the metamorphic and magmatic evolution preserved in the SAB crystalline basement, founding a model featuring opposite-direction subduction from at least late Middle Jurassic to Early Cretaceous times. The emplacement of alkaline pillow basalts directly on the oceanic crust is dated as Early to mid-Cretaceous. These dates argue the existence of abnormal mantle heat flows which may be responsible for a decrease in the density of the 80 Ma-old oceanic lithosphere prior to its obduction onto the SAB–TAP. We present a detailed review of recent data to further constrain the structural and geodynamic evolution of this sector and to define the tectonic set-up just prior to the obduction event.
The Campanian quartz ‘claystone’ conundrum of the African Transform Margin
Authors: Brown Allen , Birkhead Scott , McLean David , Towle Philip , White Howard , Wu Yafei 
Published: December 2015

Abstract
An unusual deep-water lithofacies has been penetrated by numerous wells along the equatorial margin of West Africa by Anadarko Petroleum and other operators. An exploration well drilled in 2009 was initially thought to contain very thick, high-quality sands in the Lower Campanian section. Wireline log interpretations calculated the section to be a quartz-rich reservoir rock with 67–83% quartz based on X-ray diffraction analysis and effective porosity values as high as 25%. This petrophysical analysis appeared to differ from the well site geological description of 200 m of ‘claystone’. The conflict between field observations and the interpreted wireline data led to the re-evaluation of earlier wells and interest in gathering data from this unusual lithofacies from subsequent wells. Field observations (from wellsite geologists) derived from this Lower Campanian section have been consistent in describing this lithofacies as ‘claystone’. Sidewall cores from several of the deep-water wells that penetrated this lithofacies were also consistently described as claystones. These descriptions were from visual inspection and conclusions from laboratory analysis utilizing scanning electron microscopy, X-ray diffraction analysis, laser particle size analysis and thin section point counts as evaluation tools. The sidewall cores typically contain >90% silt- and clay-sized particles with extremely low measured permeability as a result of highly reduced pore throat diameters. With the presence of such small grain sizes, these samples have high measured seal capacities. It is important to recognize that this unusual lithofacies exists and can easily be mistaken for a high-quality, quartz-rich sand when, in fact, it is a very low permeability ‘claystone’ with a high percentage of quartz. Wireline data over this lithofacies alone can be very misleading and rock samples must be analysed to validate or invalidate the log interpretations. Misidentifying this lithofacies as an exploration target could have obvious financial ramifications. The challenge of this regional study was to formulate a model that could explain the presence of this deep-water lithofacies over an extensive area encompassing several basins with different sediment source provenances. Based on well sample analysis, palaeoclimatic research and the use of modern day analogue examples, the deposition of aeolian-derived clay-sized quartz particles is proposed as the most likely source of this lithofacies.
Predictors of Human Papillomavirus Vaccination in a Large Clinical Population of Males Aged 11 to 26 years in Maryland, 2012–2013
Authors: Clarke Megan A. , Coutinho Francesca , Phelan-Emrick Darcy F. , Wilbur MaryAnn , Chou Betty , Joshu Corinne E. 
Published: December 2015

Abstract
Background: Despite the recommendation for routine human papillomavirus (HPV) vaccination in males, coverage estimates remain low. We sought to identify predictors of receiving each HPV vaccine dose among a large clinical population of males.
Methods: We conducted a cross-sectional analysis of electronic medical records for 14,688 males ages 11 to 26 years attending 26 outpatient clinics (January 2012–April 2013) in Maryland to identify predictors of each HPV vaccine dose using multivariate logistic regression models with generalized estimating equations. All analyses were stratified in accordance with vaccine age recommendations: 11 to 12 years, 13 to 21 years, and 22 to 26 years. Analyses of predictors of receipt of subsequent HPV doses were also stratified by the number of clinic visits (≤3 and &gt;3).
Results: Approximately 15% of males initiated the HPV vaccine. Less than half of males eligible received the second and third doses, 49% and 47%, respectively. Non-Hispanic black males (vs. non-Hispanic white) ages 11 to 12 and 13 to 21 years and males with public insurance (vs. private) ages 13 to 21 years had significantly greater odds of vaccine initiation, but significantly decreased odds of receiving subsequent doses, respectively. Attendance to &gt;3 clinic visits attenuated the inverse association between public insurance and receipt of subsequent doses.
Conclusion: Overall, rates of HPV vaccine initiation and of subsequent doses were low. While non-Hispanic black and publicly insured males were more likely to initiate the HPV vaccine, they were less likely to receive subsequent doses.
Impact: Tailoring different intervention strategies for increasing HPV vaccine initiation versus increasing rates of subsequent doses among males may be warranted. Cancer Epidemiol Biomarkers Prev; 25(2); 351–8. ©2015 AACR.
The Stat3/5 Signaling Biosignature in Hematopoietic Stem/Progenitor Cells Predicts Response and Outcome in Myelodysplastic Syndrome Patients Treated with Azacitidine
Authors: Miltiades Paraskevi , Lamprianidou Eleftheria , Vassilakopoulos Theodoros P. , Papageorgiou Sotirios G. , Galanopoulos Athanasios G. , Kontos Christos K. , Adamopoulos Panagiotis G. , Nakou Evangelia , Vakalopoulou Sofia , Garypidou Vassilia , Papaioannou Maria , Hatjiharissi Evdoxia , Papadaki Helen A. , Spanoudakis Emmanuil , Pappa Vassiliki , Scorilas Andreas , Tsatalas Constantinos , Kotsianidis Ioannis 
Published: December 2015

Abstract
Purpose: Azacitidine is the mainstay of high-risk myelodysplastic syndromes (MDS) therapy, but molecular predictors of response and the mechanisms of resistance to azacitidine remain largely unidentified. Deregulation of signaling via Stat3 and Stat5 in acute myeloid leukemia (AML) is associated with aggressive disease. Numerous genes involved in cell signaling are aberrantly methylated in MDS, yet the alterations and the effect of azacitidine treatment on Stat3/5 signaling in high-risk MDS have not been explored.
Experimental Design: We assessed longitudinally constitutive and ligand-induced phospho-Stat3/5 signaling responses by multiparametric flow cytometry in 74 patients with MDS and low blast count AML undergoing azacitidine therapy. Pretreatment Stat3/5 signaling profiles in CD34+ cells were grouped by unsupervised clustering. The differentiation stage and the molecular properties of the CD34+ G-CSF–inducible Stat3/5 double-positive subpopulation were performed by flow cytometry and quantitative real-time PCR in isolated MDS progenitors.
Results: The pretreatment Stat3/5 signaling profiles in CD34+ cells correlated strongly with response and cytogenetics and independently predicted event-free survival. We further identified a CD34+ G-CSF–inducible Stat3/5 double-positive subpopulation (DP subset) whose pretreatment levels were inversely associated with treatment response and cytogenetics. The kinetics of the DP subset followed the response to azacitidine and the disease course, whereas its molecular characteristics and cellular hierarchy were consistent with a leukemia propagating cell phenotype.
Conclusions: Our findings provide a novel link among Stat3/5 signaling and MDS pathobiology and suggest that the Stat3/5 signaling biosignature may serve as both a response biomarker and treatment target. Clin Cancer Res; 22(8); 1958–68. ©2015 AACR.
Suppression of Proinflammatory and Prosurvival Biomarkers in Oral Cancer Patients Consuming a Black Raspberry Phytochemical-Rich Troche
Authors: Knobloch Thomas J. , Uhrig Lana K. , Pearl Dennis K. , Casto Bruce C. , Warner Blake M. , Clinton Steven K. , Sardo-Molmenti Christine L. , Ferguson Jeanette M. , Daly Brett T. , Riedl Kenneth , Schwartz Steven J. , Vodovotz Yael , Buchta Anthony J. , Schuller David E. , Ozer Enver , Agrawal Amit , Weghorst Christopher M. 
Published: December 2015

AbstractBlack raspberries (BRB) demonstrate potent inhibition of aerodigestive tract carcinogenesis in animal models. However, translational clinical trials evaluating the ability of BRB phytochemicals to impact molecular biomarkers in the oral mucosa remain limited. The present phase 0 study addresses a fundamental question for oral cancer food–based prevention: Do BRB phytochemicals successfully reach the targeted oral tissues and reduce proinflammatory and antiapoptotic gene expression profiles? Patients with biopsy-confirmed oral squamous cell carcinomas (OSCC) administered oral troches containing freeze-dried BRB powder from the time of enrollment to the date of curative intent surgery (13.9 ± 1.27 days). Transcriptional biomarkers were evaluated in patient-matched OSCCs and noninvolved high at-risk mucosa (HARM) for BRB-associated changes. Significant expression differences between baseline OSCC and HARM tissues were confirmed using a panel of genes commonly deregulated during oral carcinogenesis. Following BRB troche administration, the expression of prosurvival genes (AURKA, BIRC5, EGFR) and proinflammatory genes (NFKB1, PTGS2) were significantly reduced. There were no BRB-associated grade 3–4 toxicities or adverse events, and 79.2% (N = 30) of patients successfully completed the study with high levels of compliance (97.2%). The BRB phytochemicals cyanidin-3-rutinoside and cyanidin-3-xylosylrutinoside were detected in all OSCC tissues analyzed, demonstrating that bioactive components were successfully reaching targeted OSCC tissues. We confirmed that hallmark antiapoptotic and proinflammatory molecular biomarkers were overexpressed in OSCCs and that their gene expression was significantly reduced following BRB troche administration. As these molecular biomarkers are fundamental to oral carcinogenesis and are modifiable, they may represent emerging biomarkers of molecular efficacy for BRB-mediated oral cancer chemoprevention. Cancer Prev Res; 9(2); 159–71. ©2015 AACR.
Serum Antibodies to HPV16 Early Proteins Warrant Investigation as Potential Biomarkers for Risk Stratification and Recurrence of HPV-Associated Oropharyngeal Cancer
Authors: Fakhry Carole , Qualliotine Jesse R. , Zhang Zhe , Agrawal Nishant , Gaykalova Daria A. , Bishop Justin A. , Subramaniam Rathan M. , Koch Wayne M. , Chung Christine H. , Eisele David W. , Califano Joseph , Viscidi Raphael P. 
Published: December 2015

Abstract
Human papillomavirus (HPV) is responsible for increasing incidence of oropharyngeal cancer. At present, there are no biomarkers in the surveillance algorithm for HPV-positive oropharyngeal cancer (HPV-OPC). HPV16 E6 antibody precedes oropharyngeal cancer diagnosis. If HPV16 E6 indeed precedes primary diagnosis, it is similarly expected to precede disease recurrence and may have a potential role as a biomarker for surveillance of HPV-OPC. To determine whether HPV antibody titers have a potential role as early markers of disease recurrence or prognosis, a retrospective pilot study was designed to determine whether HPV16 early antibody titers E6, E7, E1, and E2 decrease after treatment of HPV16-positive OPC. Trends in pretreatment, early (≤6 months after treatment), and late posttreatment (&gt;6 months after treatment) HPV16 antibody titers were examined. There were 43, 34, and 52 subjects with serum samples available for pretreatment, early, and late posttreatment intervals. Mean pretreatment antibody levels were higher than posttreatment antibody levels. Average antibody levels decreased significantly over time for E6 (Ptrend = 0.001) and E7 (Ptrend &lt; 0.001). Six disease recurrences were observed during the follow-up period (median, 4.4 years). In univariate analysis, a log-unit increase in pretreatment E6 titer was significantly associated with increased risk of disease recurrence (HR, 5.42; 95% CI, 1.1–25.7; P = 0.03). Therefore, levels of antibodies to HPV16 early oncoproteins decline after therapy. Higher E6 titers at diagnosis are associated with significant increases in the risk of recurrence. These data support the prospective evaluation of HPV16 antibodies as markers of surveillance and for risk stratification at diagnosis. Cancer Prev Res; 9(2); 135–41. ©2015 AACR.
Psychosocial Factors and Risk of Incident Heart Failure
Authors: Ogilvie Rachel P. , Everson-Rose Susan A. , Longstreth W.T. , Rodriguez Carlos J. , Diez-Roux Ana V. , Lutsey Pamela L. 
Published: December 2015

Background—
Heart failure (HF) is a major source of morbidity and mortality in the United States. Psychosocial factors have frequently been studied as risk factors for coronary heart disease but not for HF.

Methods and Results—
We examined the relationship between psychological status and incident HF among 6782 individuals from the Multi-Ethnic Study of Atherosclerosis (MESA). Anger, anxiety, chronic stress, depressive symptoms, and hostility were measured using validated scales, and physician reviewers adjudicated incident HF events. Cox proportional hazards models were used to adjust for relevant demographic, behavioral, and physiological covariates. Interactions by age, race, sex, and self-reported health were examined in exploratory analyses. During a mean follow-up of 9.3 years, 242 participants developed incident HF. There was no association between psychosocial factors and HF hazard ratios (95% confidence interval) for the highest versus lowest quartile: anger=1.14 (0.81–1.60), anxiety=0.74 (0.51–1.07), chronic stress=1.25 (0.90–1.72), depressive symptoms=1.19 (0.76–1.85), and hostility=0.95 (0.62–1.42). In exploratory analysis, among the participants reporting fair/poor health at baseline, those reporting high versus low levels of anxiety, chronic stress, and depressive symptoms had 2-fold higher risk of incident HF, but there was no association for those with good/very good/excellent self-reported health.

Conclusions—
Overall, these psychosocial factors were not significantly associated with incident HF. However, for participants reporting poor health at baseline, there was evidence that anxiety, chronic stress, and depressive symptoms were associated with increased risk of HF. Future research with greater statistical power is necessary to replicate these findings and seek explanations.
Is Myocarditis an Independent Risk Factor for Post-Transplant Mortality in Pediatric Heart Transplant Recipients?
Authors: Garbern Jessica C. , Gauvreau Kimberlee , Blume Elizabeth D. , Singh Tajinder P. 
Published: December 2015

Background—
Previous studies suggest that children with myocarditis who receive heart transplantation (HT) may be at higher risk of post-transplant mortality compared with children who are transplanted for idiopathic dilated cardiomyopathy. We hypothesized that these differences are because of more severe heart failure at HT in children with myocarditis.

Methods and Results—
We identified 221 children with myocarditis and 1583 with idiopathic dilated cardiomyopathy who were <18 years old and listed for HT in the United States between July 2004 and December 2013 using the Organ Procurement and Transplant Network database. We compared baseline characteristics at listing and at HT and used Cox models to determine whether myocarditis is independently associated with wait-list mortality (or becoming too sick to transplant) or post-transplant graft loss (death/re-HT). Children with myocarditis were more likely to be listed while on assisted ventilation, mechanical circulatory support and with renal dysfunction. Overall, 137 children with myocarditis and 1249 with idiopathic dilated cardiomyopathy received HT. In unadjusted analysis, children with myocarditis were at higher risk of wait-list mortality (hazard ratio 2.1; 95% confidence interval 1.5–3.0) and showed a trend toward increased risk of post-transplant graft loss (hazard ratio 1.4; 95% confidence interval 1.0–2.2). However, in adjusted analysis, myocarditis was not associated with wait-list mortality (hazard ratio 1.3, 95% confidence interval 0.9–1.9) or post-transplant graft loss (hazard ratio 1.3, 95% confidence interval 0.9–2.0).

Conclusions—
Among children listed for HT, those with myocarditis have more severe heart failure than children with idiopathic dilated cardiomyopathy. After adjustment for severity of illness, myocarditis does not confer additional risk for wait-list or post-transplant mortality.
Influence of Titration of Neurohormonal Antagonists and Blood Pressure Reduction on Renal Function and Decongestion in Decompensated Heart Failure
Authors: Kula Alexander J. , Hanberg Jennifer S. , Wilson F. Perry , Brisco Meredith A. , Bellumkonda Lavanya , Jacoby Daniel , Coca Steven G. , Parikh Chirag R. , Tang W.H. Wilson , Testani Jeffrey M. 
Published: December 2015

Background—
Reduction in systolic blood pressure (SBP reduction) during the treatment of acute decompensated heart failure is strongly and independently associated with worsening renal function. Our objective was to determine whether SBP reduction or titration of oral neurohormonal antagonists during acute decompensated heart failure treatment negatively influences diuresis and decongestion.

Methods and Results—

SBP reduction was evaluated from admission to discharge in consecutive acute decompensated heart failure admissions (n=656). Diuresis and decongestion were examined across a range of parameters, such as diuretic efficiency, fluid output, hemoconcentration, and diuretic dose. The average reduction in SBP was 14.4±19.4 mm Hg, and 77.6% of the population had discharge SBP lower than admission. SBP reduction was strongly associated with worsening renal function (odds ratio, 1.9; 95% confidence interval, 1.2–2.9;
P
=0.004), a finding that persisted after adjusting for parameters of diuresis and decongestion (odds ratio, 2.0; 95% confidence interval, 1.3–3.2;
P
=0.002). However, SBP reduction did not negatively affect diuresis or decongestion (
P
≥0.25 for all parameters). Uptitration of neurohormonal antagonists occurred in >50% of admissions and was associated with a modest additional reduction in blood pressure (≤5.6 mm Hg). Notably, worsening renal function was not increased, and diuretic efficiency was significantly improved with the uptitration of neurohormonal antagonists.

Conclusions—
Despite a higher rate of worsening renal function, blood pressure reduction was not associated with worsening of diuresis or decongestion. Furthermore, titration of oral neurohormonal antagonists was actually associated with improved diuresis in this cohort. These results provide reassurance that the guideline-recommended titration of chronic oral medication during acute decompensated heart failure hospitalization may not be antagonistic to the short-term goal of decongestion.
Cardiovascular Health Status and Incidence of Heart Failure in the Framingham Offspring Study
Authors: Nayor Matthew , Enserro Danielle M. , Vasan Ramachandran S. , Xanthakis Vanessa 
Published: December 2015

Background—
The American Heart Association Cardiovascular Health (CVH) score is inversely associated with cardiovascular disease, but its relations to cardiac remodeling traits and heart failure (HF) incidence have not been examined.

Methods and Results—

A 14-point score was constructed for each participant based on the presence of poor, intermediate, or ideal status on each of the 7 CVH metrics (ideal score=14). We related the CVH score to echocardiographic traits cross-sectionally and to HF incidence prospectively in the Framingham Offspring Study. In age- and sex-adjusted models, a higher CVH score was associated with lower left ventricular (LV) mass, LV wall thickness, LV diastolic dimension, and left atrial dimension (
P
<0.01 for all; n=2392; mean age, 58 years; 56% women), and with a 12% to 15% lower odds of prevalent LV concentric remodeling and concentric hypertrophy, respectively (
P
<0.0001 for both). On follow-up (mean, 12.3 years), 188 incident HF events were observed in 3201 participants (mean age, 59 years; 53% women). In age- and sex-adjusted Cox proportional hazard models, the CVH score was inversely associated with HF incidence (hazard ratio per 1-point higher CVH score, 0.77; 95% confidence interval, 0.72–0.83). This association was partially attenuated upon adjustment for LV mass and interim myocardial infarction (hazard ratio, 0.84; 95% confidence interval, 0.76–0.93), and it was consistent for HF with preserved and reduced ejection fractions.

Conclusions—
In our community-based sample, comprised predominantly of middle-aged white individuals of European descent, better CVH was associated with lower HF incidence, in part due to a lower prevalence of adverse cardiac remodeling.