bluuebunny/crossref_metadata_2025_split huggingface dataset:
A questionnaire on the current situation of resignation intention of nurses in intensive care units in China – A descriptive quantitative study
Authors: He Feng , Zhang Chunyan , Zhao Di , Zhang Chao , Zeng Liangnan , Liu Wei , Li Laiyou , Gao Fei 
Published: September 2024

AbstractAimThis study analysed and summarized the correlation between various indicators of ICU nurses' personal lives, hospital work situation, social opinion, psychological assessment, and their intention to resign.DesignA descriptive quantitative study.MethodsThis study was a multicentre questionnaire on factors influencing intensive care unit (ICU) nurses' intention to resign. This study was completed through the Critical Care E Institute (CCEI) and China Calm Therapy Research Group Academic Organization (CNCSG) by contacting ICU nurses in three hospitals in 34 provinces in China. The questionnaire was in the form of a cell phone WeChat scan code. The survey included 22 indicators, including basic information about nurses (marital and child status, personal income, etc.), hospital work (weekly working hours, night shift, hospital environment, etc.), and psychological symptoms.ResultsA total of 1904 nurses were included in this study. Among them, 1060 (55.67%) had the intention to resign. In this study, among the 22 indicators involved, 16 factors, including hospital work hours, job title, satisfaction with current income, having children, and evaluation of the hospital, significantly impact nurses' intentions to resign (all p < 0.05). Logistic regression analysis showed that six indicators influenced nurses' choice of resignation intention (all p < 0.05), including hospital work time, professional title, income satisfaction, hospital work pride, satisfaction of nurses with the compassion and care given to them by their hospitals, and career vision score. The ROC curve showed that all six indicators were <0.70, but the model receiver operating characteristic (ROC) curve constructed for the indicators was 0.756.In China, increasing the income of ICU nurses, fostering pride in hospital work, reducing working hours, ensuring smooth promotion processes, and enhancing career prospects can all decrease their likelihood of choosing to resign. Absorbing practical nursing management and work experience from other countries will help decrease the intention to resign within this group.Patient or Public ContributionNo patient or public contribution.
Sharing Is Caring? International Society for Pharmacoepidemiology Review and Recommendations for Sharing Programming Code
Authors: Tazare John , Wang Shirley V. , Gini Rosa , Prieto‐Alhambra Daniel , Arlett Peter , Morales Leaver Daniel R. , Morton Caroline , Logie John , Popovic Jennifer , Donegan Katherine , Schneeweiss Sebastian , Douglas Ian , Schultze Anna 
Published: September 2024

ABSTRACTPurposeThere is increasing recognition of the importance of transparency and reproducibility in scientific research. This study aimed to quantify the extent to which programming code is publicly shared in pharmacoepidemiology, and to develop a set of recommendations on this topic.MethodsWe conducted a literature review identifying all studies published in Pharmacoepidemiology and Drug Safety (PDS) between 2017 and 2022. Data were extracted on the frequency and types of programming code shared, and other key open science practices (clinical codelist sharing, data sharing, study preregistration, and stated use of reporting guidelines and preprinting). We developed six recommendations for investigators who choose to share code and gathered feedback from members of the International Society for Pharmacoepidemiology (ISPE).ResultsProgramming code sharing by articles published in PDS ranged from 1.8% in 2017 to 9.5% in 2022. It was more prevalent among articles with a methodological focus, simulation studies, and papers which also shared record‐level data.ConclusionProgramming code sharing is rare but increasing in pharmacoepidemiology studies published in PDS. We recommend improved reporting of whether code is shared and how available code can be accessed. When sharing programming code, we recommend the use of permanent digital identifiers, appropriate licenses, and, where possible, adherence to good software practices around the provision of metadata and documentation, computational reproducibility, and data privacy.
N‐palmitoyl‐d‐glucosamine limits mucosal damage and VEGF‐mediated angiogenesis by PPARα‐dependent suppression of pAkt/mTOR/HIF1α pathway and increase in PEA levels in AOM/DSS colorectal carcinoma in mice
Authors: Palenca Irene , Basili Franzin Silvia , Zilli Aurora , Seguella Luisa , Troiani Anna , Pepi Federico , Vincenzi Martina , Giugliano Giuseppe , Catapano Viviana , Di Filippo Italia , Sarnelli Giovanni , Esposito Giuseppe 
Published: September 2024

AbstractChronic intestinal inflammation and neo‐angiogenesis are interconnected in colorectal carcinoma (CRC) pathogenesis. Molecules reducing inflammation and angiogenesis hold promise for CRC prevention and treatment. N‐Palmitoyl‐d‐glucosamine (PGA), a natural glycolipid analog with anti‐inflammatory properties, has shown efficacy against acute colitis. Micronized PGA (mPGA) formulations exhibit superior anti‐inflammatory activity. This study investigates the in vivo anti‐angiogenic and protective effects of mPGA in a mouse model of colitis‐associated CRC induced by azoxymethane/dextran sodium sulfate (AOM/DSS). CRC was induced in C57BL/6J mice using intraperitoneal azoxymethane followed by three cycles of 2.5% dextran sodium sulfate (DSS) in drinking water. Mice were treated with mPGA (30–150 mg/kg) with or without the PPARα inhibitor MK886 (10 mg/kg). At Day 70 post‐azoxymethane injection, mice underwent anesthetized endoscopic colon evaluation. Post‐mortem analysis of tumorigenesis and angiogenesis was performed using histological, immunohistochemical, and immunoblotting techniques. mPGA improved disease progression and survival rates in a dose‐ and PPARα‐dependent manner in AOM/DSS‐exposed mice. It reduced polyp formation, decreased pro‐angiogenic CD31, pro‐proliferative Ki67, and pro‐inflammatory TLR4 expression levels, and inhibited VEGF and MMP‐9 secretion by disrupting the pAkt/mTOR/HIF1α pathway. mPGA increased colon PEA levels, restoring anti‐tumoral PPARα and wtp53 protein expression. Given its lack of toxicity, mPGA shows potential as a nutritional intervention to counteract inflammation‐related angiogenesis in CRC.
Determination of Standard Enthalpies of Formation of Organic Peroxides Using Calibration Dependencies
Authors: Poskrebyshev Gregory A. 
Published: September 2024

AbstractIn the present work, the calibration dependencies for the M062X (i=1),B3LYP (i=2), wB97XD (i=3), M08HX (i=4), MN15 (i=5), G3B3 (i=6) and CBS‐QB3 (i=7) and several other modeling approaches are determined using the calculated values of ΔraHo of atomization and literature based values of ΔraHo(X,TAB) of 14 reference peroxides. These calibration dependencies are used for the determination of ΔraHo(X,CORRP)i and ΔfHo(X,CORRP)i of other peroxides. The coordination of values of ΔfHo(X,CORRP)i (i=1–7) by the intersection of their 3σPi intervals is used for the determination of the most consistent values of ΔfHo(X,MEANP). These values of ΔfHo(X,MEANP) are used for the determination of BDE of peroxides. It's demonstrated that the calculated and literature values of BDE are in agreement. Among the considered modeling approaches, the lowest uncertainties (σPi) are determined for the G3B3 (3.1 kJ/mol), CBS‐QB3 (4.1 kJ/mol), and M062X/6‐311++G(d,p) (6.1 kJ/mol) approaches.
Nanostructured NiO for Catalytic Oxidation of CO: Microstructural and Anionic Effects of the Precursors
Authors: Bose Pallab , Basak Somjyoti , Chowdhury Ipsita Hazra , Chakraborty Adwitiya , Naskar Milan Kanti 
Published: September 2024

AbstractTransition metal oxides are suitable catalysts, capable of converting toxic carbon monoxide to carbon dioxide. Morphological and textural behaviors of the catalyst influence the catalytic conversion efficiencies. The present work highlights the role of anions of the nickel‐based precursor salts in hydrothermally synthesized (180 °C/24 h) nickel oxide catalysts toward CO conversion concerning their surface area, pore dimensions, and microstructural characteristics. Precursors having different anions used in NiO synthesis have distinct effects in shaping the physicochemical features of the synthesized catalysts governing the catalytic conversion process which were investigated in this study. The nitrate and acetate‐based NiO with flower‐like morphology exhibit a comparatively low surface area (BET) and larger pore volume and diameter than the sulfate‐based precursor. Catalytic CO oxidation study reveals that T100 i.e., the temperature to reach 100 % volume conversion of CO to CO2 was 249, 209, and 274 °C for nitrate, acetate, and sulfate‐based precursors, respectively. It was evident that the higher pore volume is a critical parameter that facilitates and governs efficient catalytic CO oxidation at comparatively low temperatures. The evolution of the pore properties and their reciprocity with the catalytic activity has been expounded in this study.
Preparation and Characterization of Biodegradable Plastic from Red Seaweed (Gracilaria sp.) from Coastal Areas in Bangladesh
Authors: Khan Navid Mahmood , Chakma Pandob , Uddin Mohammad Seraj , Monirul Hasan Chowdhury Md. 
Published: September 2024

AbstractBioplastics are biobased or biodegradable plastic synthesized from natural resources with similar features to conventional plastic and environmental sustainability. Seaweed species abundant in the coastal regions of Bangladesh are yet to be explored for developing biodegradable plastic to solve the plastic pollution problem. Semi‐refined kappa carrageenan was extracted from Gracilaria sp. with Pressurized Hot Water Extraction (PHWE) and blended with sorbitol and polyethylene glycol 1540 in this study, respectively. The presence of carrageenan and other functional groups was confirmed with FTIR analysis. The bioplastic films showed over 90 % biodegradability after 16 days of soil burial test and 98 % water solubility after immersion for 16 days. Maximum 20 MPa tensile strength and 44 % elongation were observed from the bioplastic films. The polyethylene glycol 1540 blended films showed better physical and mechanical properties. SEM analysis was conducted to evaluate the influence of tensile strength and elongation on the surface integrity of the bioplastic films. The findings indicate that Gracilaria sp. found in the coastal regions of Bangladesh, can be a potential candidate for developing bioplastics for food packaging and many other applications.
Synthesis, Antifungal, Antibacterial and Antioxidant Activities of New Pyrazolo‐Triazaphophosphorin‐2‐Oxide Derivatives.
Authors: Louiz Sonia , Abderrahim Raoudha 
Published: September 2024

AbstractThe current work describes the synthesis, characterization and antimicrobial evaluation of a new series of pyrazolo‐triazaphosphorine derivatives. The synthesized compounds were confirmed by NMR (1H,13C,31P), IR spectroscopy, by elemental analysis and LCMS. The series of phosphorus products were screened for their antifungal activities and for their antibacterial activities. Finally, the antioxidant activity was tested for one of them (2a). The results were compared with biological activities of some drugs and demonstrate that the antibacterial and antifungal activities of 2 a–f, are influenced by the variation of the group R, R’ and the donor or attractor effects of the group R′. Likewise, the donor effect of the group in compound 2 e has a positive influence on the antifungal activity and 2 e reacts against Alternaria alternata with the lowest IC50=0.795 μg mL−1 than drug. The phosphorus products can be used as some antibacterial and antifungal agents and one of the compounds(2a) have an excellent antioxidant power.
Chrysophanol‐Loaded Composites with Xanthan Gum/Polycaprolactone for Drug Release Enhancement
Authors: Thu Vu Le Thi , Thuy Nguyen Chinh , Tra Duong My , Dinh Tran Thang , Huyen Pham Trang Thi , Thi Tran Mai , Ngoc Ly Lien Thi , Thai Hoang 
Published: September 2024

AbstractThis work focused on synthesizing novel chrysophanol‐loaded composites with varied ratios of polycaprolactone/xanthan gum to enhance the release of chrysophanol. The characteristics of the obtained composites were analyzed by infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, differential scanning calorimetry, rhermogravimetric analysis and dynamic light scattering methods. The xanthan gum/polycaprolactone/chrysophanol (XPC) composites were obtained in the powdery form with particle sizes ranging from 80–100 nm. The results of hydrophilic and hydrophobic tests of the composites were discussed. Chrysophanol, polycaprolactone and xanthan gum can interact and are compatible to each other. XPC composites exhibit high stability and don't cause the negative effect on cells. Additionally, the chrysophanol release and kinetic model of chrysophanol release from the XPC composites in different pH buffer solutions were investigated and evaluated. Using drug carriers such as xanthan gum and polycaprolactone can enhance the release of chrysophanol in both pH 2.0 and pH 7.4 buffer solutions. In the presence of biopolymers, the distribution ability of chrysophanol in aqueous solutions such as pH 2.0 buffer, pH 7.4 buffer solutions, and 0.9 % NaCl solution was enhanced significantly. This will be favorable for an increase in the absorption of chrysophanol in the human body.
Effect of Co‐Crystallization on Physicochemical and Pharmacokinetic Properties of Rifaximin
Authors: Sakhiya Dhruv C. , Borkhataria Chetan H. 
Published: September 2024

AbstractRifaximin, a semi‐synthetic derivative of rifamycin is a BCS class IV drug having poor physicochemical properties. These poor physicochemical properties pose a major challenge in dosage form production and limited bioavailability restricts the systemic use of rifaximin. This study focuses on the improvement of physicochemical properties and in‐vivo bioavailability of rifaximin by utilizing co‐crystallization approach. Co‐crystallization of rifaximin with l‐proline (amino acid) resulted in improvement of physicochemical properties like saturation solubility, dissolution rate, flow‐ability, and 1.5‐fold improvement in anti‐microbial activity as compared to pure rifaximin. Ex‐vivo permeation rate was improved approximately two‐fold and in an in‐vivo study utilizing Sprague Dawley rats, relative bioavailability was estimated to be 785.5967±55.8986. The data suggest exponential improvement of both, physicochemical properties and bioavailability in the co‐crystallized form of rifaximin. This study might be a first step for the use of rifaximin in systemic infections and may open a path for rifaximin as a drug of choice for various bacterial infections.
Electrochemical Sensing Platform for Ascorbic Acid Detection Based on Porous Carbon Derived from Kudzu Root Residues
Authors: Dai Jia , Huang Ju Hua , Xiong Yi Qi , Gao Lai Fu 
Published: September 2024

AbstractKudzu root residue is an excellent biomass carbon material that can be transformed into porous carbon through a simple two‐step process of “pre‐carbonization” followed by KOH activation. The structure of carbonized and activated kudzu root residue material was characterized through various techniques such as SEM, XRD, N2 adsorption‐desorption, XPS and Raman spectroscopy. Electrochemical measurement revealed that K‐CKR exhibited outstanding electrochemical performance, attributed to its large specific surface area, significant pore volume, and microporous‐mesoporous structure. When K‐CKR was used to modify a glassy carbon electrode (GCE) for constructing an electrochemical sensor to detect ascorbic acid (AA), it demonstrated remarkable electrochemical sensing capabilities. This included a wide linear detection range (50–1620 μM), higher sensitivity, a low detection limit (0.83 μM, S/N=3), excellent stability and interference resistance. These experimental results clearly indicate that K‐CKR is a highly promising electrode material for the development of novel electrochemical sensors.
Effect of Temperature and Initiator Concentration on the Curing Reaction of an Epoxy/Amine System
Authors: Martínez Pedro Antonio Espinoza , Valdés Saúl Sánchez , Vargas Eduardo Ramírez , Silva Luciano da 
Published: September 2024

AbstractEpoxy blends of diglycidyl ether of bisphenol A (DGEBA) and 2‐[2‐(dimethylamino) ethoxy] ethanol (DMAEE) were prepared. The effect of DMAEE concentration on the rheological properties of the epoxy blends were investigated through oscillatory rheometry under isothermal conditions. A novel technique was developed to study the rheological behavior of the epoxy blends by using a Rubber Process Analyzer (RPA). The rheological study enabled analyzing the variations in the storage modulus (G’), loss modulus (G’’) and torque during the progress of the curing reaction. Additionally, the theoretical cross‐linking density (νe) and the degree of conversión of the curing reaction (α). The gel time (tgel) was determined at different temperatures, and the activation energy (Ea) was calculated by using Arrhenius‐type equation based on the gel time results. The activation energy values found are 24.79 kJ/mol and 23.01 kJ/mol. The results obtained are consistent with the values described in the literature. It was demonstrated that the proposed methodology is valid and, the use of the tertiary amine DMAEE curing agent for epoxy resins was confirmed.
Bioinspired Nanostructures by Soft‐Template Electropolymerization from Di‐Substituted Triphenylamine
Authors: Diallo Diawo , Diouf Alioune , Dramé Abdoulaye , Sene Aboubacary , Guittard Frédéric , Darmanin Thierry 
Published: September 2024

AbstractWe report a bioinspired approach to tune surface nanostructures by soft‐template electropolymerization in micellar conditions. Monomers highly favoring π‐stacking interactions are particularly interesting for favoring the polymer deposition in one direction. Here, original triphenylamine‐based monomers di‐substituted by thiophene and carbazole are investigated. Conjugated building blocks monomers are tested to favor deposition vs polymerization, even if the monomers are not perfectly planar. The carbazole derivatives have a much higher electrodeposition capacity than the thiophene derivatives, which is unexpected if thiophene and carbazole are taken alone. Moreover, in all electrodeposited films, monomer seems to be present as shown by cyclic voltammetry experiments, confirming previous works. The amount of monomer vs oligomers is highly dependent on the investigated monomer. For the resulting surface structures, hollow spheres and nanoribbons are particularly formed with some investigated monomers by cyclic voltammetry while nanotubes are observed at constant potential. The formation of nanotubes indicates a polymer growth more favored in one direction. These surfaces are less hydrophobic (water contact angle up to 111.5°) compared to films with spherical nanoparticles but these results can be explained only by the presence of air inside the surface roughness.
BaFe12O19 Functional Porous Carbon Nanocomposite as an Electrocatalyst of the Oxygen Reduction Reaction
Authors: Wu Bei , Chen Fucong , Guo Xiqiong , Li Runqiu , Guo Xiaoxiao , Zheng Hui 
Published: September 2024

AbstractIt is crucial to develop a non‐precious metal catalyst with high efficiency, affordable cost, and minimal environmental impact for conducting research on the oxygen reduction reaction (ORR) in fuel cells. In this study, BaFe12O19 functional porous carbon (BaFe12O19/PC) nanocomposite was successfully prepared using Fe2O3, BaCO3 and glucose as precursors. Meanwhile, the BaFe12O19/PC catalyst‐modified glassy carbon electrode, carbon rod, and Hg/HgO electrode were used as the working electrode, counter electrode, and reference electrode, respectively, to investigate the electrochemical behavior. The uniform distribution of nano‐scale BaFe12O19 particles in a porous carbon framework was confirmed by field emission scanning electron microscopy characterization. In addition, a double‐layer interface (Fe/Fe3C) was formed between the porous carbon and the nano‐sized BaFe12O19 particles. Fe/Fe3C has a synergistic effect with C, facilitating the migration and transfer of electrons from BaFe12O19 to porous carbon. The BaFe12O19/PC nanocomposite exhibited a four‐electron pathway for electrocatalytic kinetics, showcasing a significantly elevated half‐wave potential of 0.77 V, an impressively reduced Tafel slope of 84.95 mV/dec, and exceptional tolerance towards methanol. It is important to highlight that the BaFe12O19/PC nanocomposite not only possess high catalytic activity for oxygen reduction reactions (ORR), but also demonstrate excellent stability. Consequently, this synthesized BaFe12O19/PC nanocomposite hold promising prospects as cost‐effective and efficient catalysts in fuel cell applications.
Effects of Nucleophilic Catalysts on the Self‐Assembly of Hydrazone‐Based Supramolecular Hydrogels
Authors: Cai Peiwen , Wang Hucheng , Gao Yuliang , Li Zhongqi , Guo Xuhong , Wang Yiming 
Published: September 2024

AbstractCatalytic control over molecular self‐assembly provides a powerful approach to regulate the structures as well as the functionalities of supramolecular materials. Revealing how the catalysts affect the molecular self‐assembly process is crucial for rational design and control of the supramolecular self‐assembly systems. Herein, relying on a hydrazone‐based dynamic supramolecular hydrogel system, the effects of various nucleophilic catalysts on the self‐assembly of the hydrogels are investigated, demonstrating that the catalyst influences the hydrogelators self‐assembly via facilitating both the reaction and hydrogelators nucleation processes. The catalyst with higher catalytic activity accelerates the formation thereon the self‐assembly of hydrazone‐based hydrogelators, leading to hydrogels with more branched networks and higher stiffness. Importantly, we also verify that the catalysts, depending on the molecular structure, can also accelerate the self‐assembly process by affecting the hydrogelators nucleation process. These findings not only add more details to the effects of nucleophilic catalysts on the hydrazone‐based hydrogelation system, but also suggest that both the catalysis activity and chemical structures should be considered for catalytically controlled molecular self‐assembly.