bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recombinant human pentraxin-2 therapy in patients with idiopathic pulmonary fibrosis: safety, pharmacokinetics and exploratory efficacy
Authors: van den Blink Bernt , Dillingh Marlous R. , Ginns Leo C. , Morrison Lake D. , Moerland Matthijs , Wijsenbeek Marlies , Trehu Elizabeth G. , Bartholmai Brian J. , Burggraaf Jacobus 
Published: February 2016

Abnormal fibrogenic repair response upon alveolar injury is believed to play an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). PRM-151 (recombinant human pentraxin-2, also known as serum amyloid P), has been shown to reduce fibrosis in preclinical lung fibrosis models, and was well tolerated with a favourable pharmacokinetic profile in an earlier single-dose phase I study.A randomised, double-blind, placebo-controlled, multiple ascending dose trial was performed to assess the tolerability and pharmacokinetic and pharmacodynamic characteristics of multiple doses of PRM-151 in IPF patients. Subjects in three successive cohorts (1, 5, or 10 mg·kg−1versusplacebo) received intravenous study drug on days 1, 3, 5, 8 and 15, and were followed-up to day 57.PRM-151 was well tolerated at all dose levels, with no serious adverse reactions. Administration of PRM-151 resulted in two- to eight-fold dose-dependent increases in circulating pentraxin-2 levels. Forced vital capacity and 6-min walk test showed trends towards improvement in the combined PRM-151 dose groups. On high-resolution computed tomography scans, stable or improved lung volume unoccupied by interstitial lung abnormality was noted in some PRM-151 subjects compared to placebo subjects on day 57.The efficacy of PRM-151 in IPF remains to be investigated in dedicated future trials.
Fertility outcomes in asthma: a clinical study of 245 women with unexplained infertility
Authors: Gade Elisabeth Juul , Thomsen Simon Francis , Lindenberg Svend , Backer Vibeke 
Published: February 2016

Evidence is increasing of an association between asthma and aspects of female reproduction. However, current knowledge is limited and furthermore relies on questionnaire studies or small populations. In a prospective observational cohort study to investigate whether time to pregnancy, the number of fertility treatments, and the number of successful pregnancies differ significantly between women with unexplained infertility with and without asthma.245 women with unexplained infertility (aged 23–45 years) underwent questionnaires and asthma and allergy testing while undergoing fertility treatment. 96 women entering the study had either a former doctor's diagnosis of asthma or were diagnosed with asthma when included. After inclusion they were followed for a minimum of 12 months in fertility treatment, until they had a successful pregnancy, stopped treatment, or the observation ended.The likelihood of achieving pregnancy was lower in women with asthma compared with those without asthma: median total time to pregnancy was 32.3 months in non-asthmatic womenversus55.6 months in those with asthma, hazard ratio 0.50 (95% confidence interval 0.34–0.74) p<0.001.Women with asthma had fewer successful pregnancies during fertility treatment, 39.6versus60.4% (p=0.002). Increasing age was of negative importance for expected time to pregnancy, especially among asthmatic women (interaction between age and asthma on time to pregnancy, p=0.001). Female asthmatics had a longer time to pregnancy and less often became pregnant than non-asthmatic women. Increasing age reduced the chances of conceiving especially among asthmatic women. The causal relationship between asthma and subfertility remains unclear.
A new method to measure complexity in binary or weighted networks and applications to functional connectivity in the human brain
Authors: Hahn Klaus , Massopust Peter R. , Prigarin Sergei 
Published: February 2016

Abstract
Background
Networks or graphs play an important role in the biological sciences. Protein interaction networks and metabolic networks support the understanding of basic cellular mechanisms. In the human brain, networks of functional or structural connectivity model the information-flow between cortex regions. In this context, measures of network properties are needed. We propose a new measure, Ndim, estimating the complexity of arbitrary networks. This measure is based on a fractal dimension, which is similar to recently introduced box-covering dimensions. However, box-covering dimensions are only applicable to fractal networks. The construction of these network-dimensions relies on concepts proposed to measure fractality or complexity of irregular sets in $\mathbb {R}^{n}$

ℝ

n

.

Results
The network measure Ndim grows with the proliferation of increasing network connectivity and is essentially determined by the cardinality of a maximum k-clique, where k is the characteristic path length of the network. Numerical applications to lattice-graphs and to fractal and non-fractal graph models, together with formal proofs show, that Ndim estimates a dimension of complexity for arbitrary graphs. Box-covering dimensions for fractal graphs rely on a linear log−log plot of minimum numbers of covering subgraph boxes versus the box sizes. We demonstrate the affinity between Ndim and the fractal box-covering dimensions but also that Ndim extends the concept of a fractal dimension to networks with non-linear log−log plots. Comparisons of Ndim with topological measures of complexity (cost and efficiency) show that Ndim has larger informative power. Three different methods to apply Ndim to weighted networks are finally presented and exemplified by comparisons of functional brain connectivity of healthy and depressed subjects.

Conclusion
We introduce a new measure of complexity for networks. We show that Ndim has the properties of a dimension and overcomes several limitations of presently used topological and fractal complexity-measures. It allows the comparison of the complexity of networks of different type, e.g., between fractal graphs characterized by hub repulsion and small world graphs with strong hub attraction. The large informative power and a convenient computational CPU-time for moderately sized networks may make Ndim a valuable tool for the analysis of biological networks.
Bone marrow-derived mesenchymal stromal cells differ in their attachment to fibronectin-derived peptides from term placenta-derived mesenchymal stromal cells
Authors: Maerz Jan K. , Roncoroni Lorenzo P. , Goldeck David , Abruzzese Tanja , Kalbacher Hubert , Rolauffs Bernd , DeZwart Peter , Nieselt Kay , Hart Melanie L. , Klein Gerd , Aicher Wilhelm K. 
Published: February 2016

Abstract
Introduction
Human mesenchymal stromal cells (MSCs) can be isolated from different sources including bone marrow and term placenta. These two populations display distinct patterns of proliferation and differentiation in vitro. Since proliferation and differentiation of cells are modulated by cell–matrix interactions, we investigated the attachment of MSCs to a set of peptide-coated surfaces and explored their interactions with peptides in suspension.

Methods
Human MSCs were isolated from bone marrow and term placenta and expanded. Binding of MSCs to peptides was investigated by a cell-attachment spot assay, by blocking experiments and flow cytometry. The integrin expression pattern was explored by a transcript array and corroborated by quantitative reverse transcription polymerase chain reaction and flow cytometry.

Results
Expanded placenta-derived MSCs (pMSCs) attached well to surfaces coated with fibronectin-derived peptides P7, P15, and P17, whereas bone marrow-derived MSCs (bmMSCs) attached to P7, but barely to P15 and P17. The binding of bmMSCs and pMSCs to the peptides was mediated by β1 integrins. In suspension, expanded bmMSCs barely bind to P7, P13, P15, and less to P14 and P17. Ex vivo, bmMSCs failed to bind P7, but displayed a weak interaction with P13, P14, and P15. In suspension, expanded pMSCs displayed binding to many peptides, including P4, P7, P13, P14, P15, and P17. The differences observed in binding of bmMSCs and pMSCs to the peptides were associated with significant differences in expression of integrin α2-, α4-, and α6-chains.

Conclusions
Human bmMSCs and pMSCs show distinct patterns of attachment to defined peptides and maintain differences in expression of integrins in vitro. Interactions of ex vivo bmMSCs with a given peptide yield different staining patterns compared to expanded bmMSCs in suspension. Attachment of expanded MSCs to peptides on surfaces is different from interactions of expanded MSCs with peptides in suspension. Studies designed to investigate the interactions of human MSCs with peptide-augmented scaffolds or peptides in suspension must therefore regard these differences in cell–peptide interactions.
ReCAP: Perspectives of Patients, Caregivers, and Medical Staff on Greetings in Oncology Practice: A Prospective Survey
Authors: Limon Dror , Perry Shlomit , Granot Tal , Gordon Noa , Stemmer Naama , Stemmer Salomon M. , Limon Dror , Perry Shlomit , Granot Tal , Gordon Noa , Stemmer Naama , Stemmer Salomon M. 
Published: February 2016

QUESTION ASKED:What is the preferred greeting process (name calling, hand shaking) in oncology practice, by patients, caregivers and medical staff?SUMMARY ANSWER:Findings suggest that patients with cancer in Israel prefer a casual environment that includes calling them by their given name and shaking hands. Yet, they prefer that physicians introduce themselves in a more formal manner, with full name and title.METHODS:A total of 186 patients and 104 caregivers visiting the outpatient clinics at the Davidoff Cancer Institute completed a questionnaire about greeting-related preferences. Similar questionnaires were completed by 93 staff members (physicians, nurses, secretaries, and psychosocial team).BIAS, CONFOUNDING FACTOR(S), DRAWBACKS:First, our attempt to delineate the greeting process is artificial, because a human encounter is much more than just gestures. Also, this was a single-center study, and some of the subgroups were too small to analyze. Last, the answers provided by respondents were not verified by real observations of medical staff–patient meetings.REAL-LIFE IMPLICATIONS:This survey provides insights that may help oncology professionals in building relationships with their patients. Our findings of patients' preferences and ideas about the desired interactions between them and the medical staff may provide guidance on how to approach patients with cancer. Encounters between patients and medical staff are the foundation for building the patient–medical staff relationship, which is a keystone of cancer care. This survey may facilitate the initiation of such future interactions. [Table: see text]
ReCAP: Attitudes, Beliefs, and Awareness of Graduate Medical Education Trainees Regarding Palliative Care at a Comprehensive Cancer Center
Authors: Wong Angelique , Reddy Akhila , Williams Janet L. , Wu Jimin , Liu Diane , Bruera Eduardo , Wong Angelique , Reddy Akhila , Williams Janet L. , Wu Jimin , Liu Diane , Bruera Eduardo 
Published: February 2016

QUESTION ASKED: What are graduate medical education trainees’ attitudes and beliefs regarding palliative care, what is their awareness of the availability and role of palliative care services, and does previous exposure to a palliative care rotation facilitate a better awareness of palliative care? SUMMARY ANSWER: A vast majority of oncology trainees perceived palliative care services to be beneficial for patient care (92%) and were supportive of mandatory palliative care training (74%). Surgical oncology trainees and trainees with no previous palliative care exposure were significantly less likely to consult palliative care and had significantly less awareness of palliative care. METHODS: We conducted an institutional review board–approved online survey to determine awareness of palliative care among graduate medical trainees at MD Anderson. One hundred seventy oncology trainees who completed at least 9 months of training in medical, surgical, gynecologic, and radiation oncology fellowship and residency program during the 2013 academic year completed an online questionnaire. Descriptive, univariate, and multivariate analyses were performed. BIAS, CONFOUNDING FACTOR(S), DRAWBACKS: Although there was a substantial response rate (78%), the results may not be generalizable as the survey was conducted at a single institution. Also, the frequency of palliative care referrals is self-reported. REAL-LIFE IMPLICATIONS: Our findings suggest that exposure to palliative care training may lead to increased awareness of palliative care among oncologists, and thus, increased overall and early referrals to palliative care. Surgical oncology trainees may benefit from increased exposure to palliative care rotations. More research is needed to characterize the impact of training on referral patterns to palliative care. In the meantime, efforts should be made to include formal palliative care rotations in oncology training. [Table: see text]
Development of a Cancer Care Summary Through the Electronic Health Record
Authors: Carr Laurie L. , Zelarney Pearlanne , Meadows Sarah , Kern Jeffrey A. , Long M. Bronwyn , Kern Elizabeth 
Published: February 2016

Introduction: Our objective was to improve communication concerning lung cancer patients by developing and distributing a Cancer Care Summary that would provide clinically useful information about the patient’s diagnosis and care to providers in diverse settings. Methods: We designed structured, electronic forms for the electronic health record (EHR), detailing tumor staging, classification, and treatment. To ensure completeness and accuracy of the information, we implemented a data quality cycle, composed of reports that are reviewed by oncology clinicians. The data from the EHR forms are extracted into a structured query language database system on a daily basis, from which the Summaries are derived. We conducted focus groups regarding the utility, format, and content of the Summary. Cancer Care Summaries are automatically generated 4 months after a patient’s date of diagnosis, then every 6 months for those receiving treatment, and on an as-needed basis for urgent care or hospital admission. Results: The product of our improvement project is the Cancer Care Summary. To date, 102 individual patient Summaries have been generated. These documents are automatically entered into the National Jewish Health (NJH) EHR, attached to correspondence to primary care providers, available to patients as electronic documents on the NJH patient portal, and faxed to emergency departments and admitting physicians on patient evaluation. Conclusion: We developed a sustainable tool to improve cancer care communication. The Cancer Care Summary integrates information from the EHR in a timely manner and distributes the information through multiple avenues.
The CD44s splice isoform is a central mediator for invadopodia activity
Authors: Zhao Pu , Xu Yilin , Wei Yong , Qiu Qiong , Chew Teng-Leong , Kang Yibin , Cheng Chonghui 
Published: February 2016

ABSTRACT
The ability for tumor cells to spread and metastasize to distant organs requires proteolytic degradation of extracellular matrix (ECM). This activity is mediated by invadopodia, actin-rich membrane protrusions that are enriched for proteases. However, the mechanisms underlying invadopodia activity are not fully understood. Here, we report that a specific CD44 splice isoform, CD44s, is an integral component in invadopodia. We show that CD44s, but not another splice isoform CD44v, is localized in invadopodia. Small hairpin (sh)RNA-mediated depletion of CD44s abolishes invadopodia activity, prevents matrix degradation and decreases tumor cell invasiveness. Our results suggest that CD44s promotes cortactin phosphorylation and recruits MT1-MMP (also known as MMP14) to sites of matrix degradation, which are important activities for invadopodia function. Importantly, we show that depletion of CD44s inhibits breast cancer cell metastasis to the lung in animals. These findings suggest a crucial mechanism underlying the role of the CD44s splice isoform in breast cancer metastasis.
Εικόνες της Κρητικής Σχολής στην Καστοριά
Authors: ΤΣΙΓΑΡΙΔΑΣ Ε. Ν. 
Published: February 2016

<p><em>Στο άρθρο αυτό δημοσιεύονται δεκαπέντε εικόνες κρητικής σχολής, οι οποίες βρίσκονται στην Καστοριά. Οι εικόνες αυτές, οι οποίες χρονικά εκτείνονται από τα τέλη του 15ου έως τα τέλη του 17ου αιώνα, δεν είναι παραγωγή τοπικών εργαστηρίων, αλλά έχουν εισαχθεί στην πόλη, μαζί με άλλα αγαθά, από πλούσιους εμπόρους της Καστοριάς, είτε από τη Βενετία, μέσω των πόλεων της Αδριατικής, είτε μέσω των ενετοκρατούμενων νήσων του Ιονίου, κυρίως της Κέρκυρας. Από τις εικόνες αυτές δύο είναι ενυπόγραφα έργα του Ιωάννου Περμενιάτη και άλλες δύο του Θεοδώρου Πουλάκη.</em></p><p> </p>
Doctors’ rehabilitation from a position of psychosomatic medicine
Authors: Кулемзина  , Kulemzina T. 
Published: February 2016

This article deals with the doctors working in conditions of combat situation. Stressors, effecting
on civilian physician in ordinary everyday practical work within the profession are differ from those in combat.
Since civilian doctors are in the same combat conditions as other soldiers, they are also exposed to combat
stressors specific and non-specific to the combat situation. Civilian doctors in a combat situation, often neglected
the risk, assess it inappropriately, violate well-established discipline, as the task of providing emergency assistance
reaches. In this context, the purpose of this study was to demonstrate the complexity of the use of nonpharmacological
methods in psychosomatic disorders in civilian doctors performing their responsibilities in the
combat situations. Diagnostic, therapeutic and preventive measures were determined on the basis of a holistic
approach to patients. The authors used the methods of reflexology, homeotherapy and practical psychology (holodynamics).
Therapeutic process was planned in such a way as to reduce the risk of exacerbations, particularly
during combined use of methods, as it was the limited by time factor.
Strategies and techniques of providing crisis psychological assistance to adolescents depending on psychological state and personality characteristics
Authors: Банников  , Bannikov G. , Кошкин  , Koshkin K. , Павлова  , Pavlova T. 
Published: February 2016

The provision of effective assistance to minors in crisis situations is a complex task for specialists
of different specialties. To define the patterns of providing crisis psychological assistance to adolescents with
anti-vital experiences and self-injurious behavior depending on the stage of development of crisis states, 60 adolescents
(24 boys and 36 girls, the average age was 15.7±6 years ) were examined by a therapist in medical and
psychological services in Moscow. Analysis of the obtained data allowed to identify three groups of adolescents
differing in personal characteristics, the peculiarities of response in a traumatic situation and structure of manifestations
of suicidal markers, anti-vital and auto-aggressive trends: sensitive-schizoid/narcissistic (25%), emotionally
unstable/borderline (45%), depressive/obsessive-compulsive (30%). Tree stages of development of crisis
states are considered: acute, sub-acute and chronic. Depending on the actual stage of the crisis state the authors
described the strategies of psychological intervention. The proposed structure of providing psychological assistance
to minors in crisis situations allows to organize the structural and dynamic features of various stages of
rendering psychiatric assistance, but also increases the likelihood of a favorable prognosis due to the unified efforts
of different specialists
The influence of social environment on patient concept оn psychotherapeutic intervention efficacy
Authors: Безденежных  , Bezdenezhnykh B. , Агарков  , Agarkov V. , Бронфман  , Bronfman S. , Черненко  , Chernenko A. 
Published: February 2016

One of the most important factors, influencing the development on concept of confidence in
psychotherapy is social environment.
The analysis of expectations of Russian patients towards psychotherapy (this construct with a certain limitations
can be assimilated to concept of confidence in psychotherapy) requires taking into account social environment
factor, including social-demographic situation in the Russian Federation. According to the results of a
survey of the Public Opinion Foundation (POF) including 1500 individuals aged 18+ years (dated November 2014), the use of psychotherapeutic and psychological services decreased since 2006 by 20% (!) and today constitutes
less than 20%. According to participant’s opinion, the accessibility of psychotherapeutic service slightly
increased (by 5%). During the same time period the number of respondents who are certain that reference to psychologists
or psychotherapists is worthless increased by 8%. At the same time, according to national statistical
investigations, more than 30% of population has psychiatric conditions requiring medical help or consultation of
a psychiatrist, or, more often, a psychotherapist or clinical psychologist. Consequently, there is a decrease of
confidence in psychotherapy among potential service consumers in our country, which is to no small degree associated
with concern of disapproval of psychotherapeutic help by reference group (friends, colleagues, family
members etc.). In other words, psychotherapeutic or psychological help will be associated with shame and insecurity.
The reason for such an attitude of population to psychotherapeutic treatment are likely distorted perception,
associated with lack of information, apprehensive attitude towards psychiatric treatment (which is closely
related in the public consciousness to psychotherapy). The attitude of internists and health officials towards psychotherapy
may play an important role in the discrediting psychotherapy. One gets the impression that nowadays
at the present stage of development of psychotherapy in our country, educational function of psychotherapist
becomes of paramount significance. It should be aimed both at the development of knowledge on the efficacy of
psychotherapeutic methods and at the necessity of engagement of psychotherapists and psychologists in diagnostics
and treatment alongside with internal medicine doctors, and also at the promotion of credibility of psychotherapy
among the potential users of psychotherapeutic services.
Exercise stress - criteria fitness athlete
Authors: Белых  , Belykh E. , Еськов  , Eskov V. , Фудин  , Fudin N. , Троицкий  , Troitskiy A. 
Published: February 2016

The article described a common statistical processing of information from the human body, as
insufficiently correct, the necessity of evaluation functions organiz-ma, its adaptation reserves - with the help of
the system analysis. The aim of the study was the use-tion of new products on the basis of multivariate phase
space of states. Two CHECK dennyh research unit in 2 groups of students studied parameters of tremor using
bioizme-nary complex with no load and load, as well as the recorded heart rate cut-ny, calculated indicators of
activity of the sympathetic and parasympathetic divisions of the autonomic nervous system, the standard deviation
intervals, Baevsky stress index. We calculated the components of the spectral power in the low and ultralow-
frequency bands, as well as the value of vagosympathetic balance. After the standardized dynamic loading
(30 squats) registration continued for 5 minutes. Using innovative methods proved to be more sensitive to the
identification of the elements studied. The regularities in the dynamics of the behavior of the state vector of the
body of persons trained and untrained should be used to quantify the degree of detraining of the body, as well as
to assess the quality of the dose of physical activity (exercise) in athletes under relevant preparations (including
sports).