bluuebunny/crossref_metadata_2025_split huggingface dataset:
An isoflavone enriched diet increases skeletal muscle adaptation in response to physical activity in ovariectomized rats
Authors: Zheng Wenya , Hengevoß Jonas , Soukup Sebastian T. , Kulling Sabine E. , Xie Mingyong , Diel Patrick 
Published: May 2017

ScopeThis study was to investigate anabolic adaptation of skeletal muscle in response to an isoflavone (ISO) enriched diet, training and their combinations in ovariectomized (OVX) rats.Methods and resultsFemale Wistar rats were sedentary, performed treadmill uphill running, received ISOs, or a combination of ISOs and running after ovariectomy. Body weight was increased by OVX. Both ISO and training treatment antagonized this increase. The weights of soleus and gastrocnemius muscles were increased only when training and ISOs were combined. In soleus muscle insulin‐like growth factor (IGF)‐1R, MyoD and Myogenin expressions were only up‐regulated by training in Sham groups. However, a stimulation of IGF‐1R and MyoD expression could be observed when ISOs and training were combined. In gastrocnemius muscle MyoD and Myogenin expressions were stimulated by either training or ISOs. Additive effects were detected when combining the two interventions.ConclusionOur results indicate that the combination of ISOs and exercise is more efficient in increasing relative skeletal muscle mass and the expression of molecular markers related to anabolic adaptation in the skeletal muscle of female rats.
Accurate assessment of alpha‐gal syndrome using cetuximab and bovine thyroglobulin‐specific IgE
Authors: Sim Da Woon , Lee Jong Sun , Park Kyung Hee , Jeong Kyoung Yong , Ye Young‐Min , Lee Jae‐Hyun , Park Jung‐Won 
Published: May 2017

ScopeIgE against galactose‐α‐1,3‐galactose (α‐Gal) causes alpha‐gal syndrome. Bovine thyroglobulin (BTG) and cetuximab share this epitope. We aimed to determine the utility of specific IgE (sIgE) against cetuximab as compared to BTG for diagnosing alpha‐gal syndrome.Methods and resultsTwelve patients with alpha‐gal syndrome, 11 patients with immediate beef or pork allergy, 18 asymptomatic individuals with meat sensitization, and 10 non‐atopic subjects were enrolled. We checked the levels of sIgE against BTG and cetuximab using the streptavidin CAP assay. Additionally, IgE reactivity to BTG and cetuximab was assessed by immunoblotting. All alpha‐gal syndrome patients had a high concentration of sIgE against BTG, and cetuximab. In contrast to alpha‐gal syndrome, patients with immediate allergic reactions to meat consumption and those with asymptomatic sensitization had significantly lower concentration of BTG and cetuximab sIgE, and a high prevalence of sIgE against bovine or porcine serum albumin. Although the concentration of sIgE against alpha‐gal was lower in individuals with asymptomatic sensitization, IgE immunoblotting showed the presence of sIgE against α‐Gal in this group.ConclusionDifferentiation of alpha‐gal syndrome from patients with immediate allergy to meat consumption or asymptomatic sensitization requires quantification of cetuximab‐ or BTG‐induced sIgE via detection of IgE for α‐gal.
Harnessing polarisation transfer to indazole and imidazole through signal amplification by reversible exchange to improve their NMR detectability
Authors: Fekete Marianna , Rayner Peter J. , Green Gary G. R. , Duckett Simon B. 
Published: May 2017

The signal amplification by reversible exchange (SABRE) approach has been used to hyperpolarise the substrates indazole and imidazole in the presence of the co‐ligand acetonitrile through the action of the precataysts [IrCl(COD)(IMes)] and [IrCl(COD)(SIMes)]. 2H‐labelled forms of these catalysts were also examined. Our comparison of the two precatalysts [IrCl(COD)(IMes)] and [IrCl(COD)(SIMes)], coupled with 2H labelling of the N‐heterocyclic carbene and associated relaxation and polarisation field variation studies, demonstrates the critical and collective role these parameters play in controlling the efficiency of signal amplification by reversible exchange. Ultimately, with imidazole, a 700‐fold1H signal gain per proton is produced at 400 MHz, whilst for indazole, a 90‐fold increase per proton is achieved. The co‐ligand acetonitrile proved to optimally exhibit a 190‐fold signal gain per proton in these measurements, with the associated studies revealing the importance the substrate plays in controlling this value. Copyright © 2017 The Authors. Magnetic Resonance in Chemistry published by John Wiley & Sons Ltd.
Designing 3D selective adiabatic radiofrequency pulses with single and parallel transmission
Authors: Jang Albert , Wu Xiaoping , Auerbach Edward J. , Garwood Michael 
Published: May 2017

PurposeTo introduce a method of designing single and parallel transmit (pTx) 3D adiabatic π pulses for inverting and refocusing spins that are insensitive to transmit B1 (
) inhomogeneity.Theory and MethodsA 3D adiabatic pulse is created by replacing each piece‐wise constant element (or sub‐pulse) of an adiabatic full passage (AFP) by a 2D selective pulse. In this study, the parent AFP is an HS1 and each sub‐pulse is a 2D pulse derived from a jinc function designed using a spiral k‐trajectory. Spatial selectivity in the third direction is achieved by blipping the slab‐selective gradient between sub‐pulses, yielding a rectangular slab profile identical to that of the parent AFP. The slew‐rate limited sub‐pulse can be undersampled utilizing pTx, thus shortening the overall pulse width. Simulations and experiments demonstrate the quality of spatial selectivity and adiabaticity achievable.ResultsThe 3D adiabatic pulse inverts and refocus spins in a sharply demarcated cylindrical volume. When stepping RF amplitude, an adiabatic threshold is observed above which the flip angle remains π. Experimental results demonstrate that pTx is an effective means to significantly improve pulse performance.ConclusionA method of designing 3D adiabatic pulses insensitive to B1 inhomogeneity has been developed. pTx can shorten these pulses while retaining their adiabatic character. Magn Reson Med 79:701–710, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Accelerated whole‐heart MR angiography using a variable‐density poisson‐disc undersampling pattern and compressed sensing reconstruction
Authors: Moghari Mehdi H. , Uecker Martin , Roujol Sébastien , Sabbagh Majid , Geva Tal , Powell Andrew J. 
Published: May 2017

PurposeTo accelerate whole‐heart three‐dimension MR angiography (MRA) by using a variable‐density Poisson‐disc undersampling pattern and a compressed sensing (CS) reconstruction algorithm, and compare the results with sensitivity encoding (SENSE).MethodsFor whole‐heart MRA, a prospective variable‐density Poisson‐disc k‐space undersampling pattern was developed in which 1–2% of central part of k‐space was fully sampled, and sampling in the remainder decreased exponentially toward the periphery. The undersampled data were then estimated using CS reconstruction. In patients, images using this sequence with an undersampling rate of ≈6 were compared with those using a SENSE rate of 2 (n = 15) and a SENSE rate of 6 (n = 13).ResultsCompared with SENSE rate 2, CS rate 6 images had similar objective border sharpness, significantly lower subjective image quality scores at all four locations (all P < 0.01), and shorter scan times (P < 0.05). Compared with SENSE rate 6, CS rate 6 had similar objective border sharpness at all four locations, significantly better subjective image quality scores at three of four locations (all P < 0.01), and similar scan times (P = 0.24).ConclusionCompared with SENSE with a comparable acceleration rate, a variable‐density Poisson‐disc undersampling pattern and CS reconstruction achieved better subjective image quality and similar border sharpness. Magn Reson Med 79:761–769, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
5D whole‐heart sparse MRI
Authors: Feng Li , Coppo Simone , Piccini Davide , Yerly Jerome , Lim Ruth P. , Masci Pier Giorgio , Stuber Matthias , Sodickson Daniel K. , Otazo Ricardo 
Published: May 2017

PurposeA 5D whole‐heart sparse imaging framework is proposed for simultaneous assessment of myocardial function and high‐resolution cardiac and respiratory motion‐resolved whole‐heart anatomy in a single continuous noncontrast MR scan.MethodsA non–electrocardiograph (ECG)‐triggered 3D golden‐angle radial balanced steady‐state free precession sequence was used for data acquisition. The acquired 3D k‐space data were sorted into a 5D dataset containing separated cardiac and respiratory dimensions using a self‐extracted respiratory motion signal and a recorded ECG signal. Images were then reconstructed using XD‐GRASP, a multidimensional compressed sensing technique exploiting correlations/sparsity along cardiac and respiratory dimensions. 5D whole‐heart imaging was compared with respiratory motion‐corrected 3D and 4D whole‐heart imaging in nine volunteers for evaluation of the myocardium, great vessels, and coronary arteries. It was also compared with breath‐held, ECG‐gated 2D cardiac cine imaging for validation of cardiac function quantification.Results5D whole‐heart images received systematic higher quality scores in the myocardium, great vessels and coronary arteries. Quantitative coronary sharpness and length were always better for the 5D images. Good agreement was obtained for quantification of cardiac function compared with 2D cine imaging.Conclusion5D whole‐heart sparse imaging represents a robust and promising framework for simplified comprehensive cardiac MRI without the need for breath‐hold and motion correction. Magn Reson Med 79:826–838, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Dynamic resource allocation for big data streams based on data characteristics (5Vs)
Authors: Kaur Navroop , Sood Sandeep K. 
Published: May 2017

SummaryVarious Internet‐based applications such as social media, business transactions, mobile applications, cyber‐physical systems, and Internet of Things have led to the generation of big data streams in every field. The growing need to extract knowledge from big data streams has pioneered the challenge of selecting appropriate cloud resources. The current techniques allocate resources based on data characteristics. But because of the stochastic nature of data generation, the characteristics of data in big data streams are unknown. This poses difficulty in selecting and allocating appropriate resources to big data stream. Working towards this direction, this paper proposes a system that predicts the data characteristics in terms of volume, velocity, variety, variability, and veracity. The predicted values are expressed in a quadruple called Characteristics of Big data (CoBa). Thereafter, the proposed system uses self‐organizing maps to dynamically create clusters of cloud resources. One of these clusters is allocated to the big data stream based on its CoBa. The proposed system is dynamic in the sense that it changes the cloud cluster allocated to big data stream if its CoBa changes. Experimental results show that the proposed system has a performance edge over other streaming data processing tools such as Storm, Flume, and S4.
Design, preparation, and characterization of fast cure epoxy/amine‐functionalized graphene oxide nanocomposites
Authors: Nonahal Milad , Saeb Mohammad Reza , Hassan Jafari Seyed , Rastin Hadi , Khonakdar Hossein Ali , Najafi Farhood , Simon Frank 
Published: May 2017

Fast cure epoxy/amine‐functionalized graphene oxide (GO) nanocomposites were designed, prepared, and characterized in this work. The GO nanosheets were functionalized by aliphatic amines having the same structure but different chain length. XPS and FTIR analyses were used to probe chemical structure and elemental surface composition of nanosheets before and after functionalization. Cure kinetics analysis was performed by dynamic differential scanning calorimetry (DSC) on samples containing pristine and functionalized GO to achieve minimum possible hindered cure. Kinetic studies confirmed that addition of pristine GO brings a steric hindrance effect, as signaled by a fall in the onset temperature, exotherm temperature and the total heat of curing reaction. According to isoconversional model, activation energy of cure reaction fell from approximately 80 to slightly over 60 kJ mol−1 as a result of improved dispersion. SEM micrographs provided evidence for good dispersion of GO platelets bearing short‐arm amines; but activation energy in such system was surprisingly higher than that of the one filled with pristine GO. By contrast, network formation in nanocomposites with GO functionalized by long‐arm amine has been facilitated, signifying the dominance of aliphatic amine length over dispersion state. The accelerated/decelerated cure is inferred based on the reactivity of reaction moieties, dispersion state of GO in the epoxy matrix, and cure behavior/kinetics of nanocomposites. The developed fast cure epoxy/GO nanocomposites compete in crosslinking with blank epoxy system. POLYM. COMPOS., 39:E2016–E2027, 2018. © 2017 Society of Plastics Engineers
Untargeted Metabolomic Analysis of Capsicum spp. by GC–MS
Authors: Aranha Bianca Camargo , Hoffmann Jessica Fernanda , Barbieri Rosa Lia , Rombaldi Cesar Valmor , Chaves Fábio Clasen 
Published: May 2017

AbstractIntroductionIn order to conserve the biodiversity of Capsicum species and find genotypes with potential to be utilised commercially, Embrapa Clima Temperado maintains an active germplasm collection (AGC) that requires characterisation, enabling genotype selection and support for breeding programmes.ObjectiveThe objective of this study was to characterise pepper accessions from the Embrapa Clima Temperado AGC and differentiate species based on their metabolic profile using an untargeted metabolomics approach.Material and MethodsCold (˗20°C) methanol extraction residue of freeze‐dried fruit samples was partitioned into water/methanol (A) and chloroform (B) fractions. The polar fraction (A) was derivatised and both fractions (A and B) were analysed by gas chromatography coupled to mass spectrometry (GC–MS). Data from each fraction was analysed using a multivariate principal component analysis (PCA) with XCMS software.ResultsAmino acids, sugars, organic acids, capsaicinoids, and hydrocarbons were identified. Outlying accessions including P116 (C. chinense), P46, and P76 (C. annuum) were observed in a PCA plot mainly due to their high sucrose and fructose contents. PCA also indicated a separation of P221 (C. annuum) and P200 (C. chinense), because of their high dihydrocapsaicin content.ConclusionsAlthough the metabolic profiling did not allow for grouping by species, it permitted the simultaneous identification and quantification of several compounds complementing and expanding the metabolic database of the studied Capsicum spp. in the AGC. Copyright © 2017 John Wiley & Sons, Ltd.
Novel cationic rare earth metal alkyl catalysts for precise olefin polymerization
Authors: Yang Fanzhi , Li Xiaofang 
Published: May 2017

ABSTRACTThis mini‐review provides recent progress in the synthesis of rare earth metal dialkyl complexes and their application as highly efficient and regio‐/stereoselective catalysts in the coordination‐insertion (co)polymerization of olefins such as styrene, isoprene, 1,3‐cyclohexadiene, and ocimene. Through modifying the coordination atom, the ligand skeleton, and the substitutent on the skeleton of the chelating ligand, tuning the electron density and the steric environment around the rare earth metal center, the precise control of the activity and regio‐/stereoselectivity of the (co)polymerization as well as the comonomer incorporation and sequence distribution of the resulting copolymers are achieved. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 2271–2280
Can Extensional Flow Rupture Macromolecules in an Electrospinning Process?
Authors: Sun Chenggui , Ayranci Cagri , Chen Yu , Boluk Yaman 
Published: May 2017

ABSTRACTThe fracture of high molecular weight poly(ethylene oxide) (PEO) chains under extensional stretching during the electrospinning of aqueous solutions was investigated by measuring solution viscosities and monitoring the change of molecular weight. The degree of macromolecular chain fractures in 1.0% polymer solutions increased with the increase in molecular weight. The strain rates for stretching and fracturing of macromolecules are critical for the degradation of polymers along with experimental elongational strain rates. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2017, 55, 1051–1054
Negative psychological consequences of breast cancer among recently diagnosed ethnically diverse women
Authors: Tejeda Silvia , Stolley Melinda R. , Vijayasiri Ganga , Campbell Richard T. , Estwing Ferrans Carol , Warnecke Richard B. , Rauscher Garth H. 
Published: May 2017

AbstractObjectiveBreast cancer has psychological consequences that impact quality of life. We examined factors associated with negative psychological consequences of a breast cancer diagnosis, in a diverse sample of 910 recently diagnosed patients (378 African American, 372 white, and 160 Latina).MethodsPatients completed an in‐person interview as part of the Breast Cancer Care in Chicago study within an average of 4 months from diagnosis. The Cockburn negative psychological consequences of breast cancer screening scale was revised to focus on a breast cancer diagnosis. Path analysis assessed predictors of psychological consequences and potential mediators between race/ethnicity and psychological consequences.ResultsCompared to white counterparts, bivariate analysis showed African American (β = 1.4, P < .05) and Latina (β = 3.6, P < .001) women reported greater psychological consequences. Strongest predictors (P < .05 for all) included unmet social support (β = .38), and provider trust (β = .12), followed by stage at diagnosis (β = .10) and perceived neighborhood social disorder (β = .09).The strongest mediator between race/ethnicity and psychological consequences was unmet social support.ConclusionsAfrican American and Latina women reported greater psychological consequences related to their breast cancer diagnosis; this disparity was mediated by differences in unmet social support. Social support represents a promising point of intervention.
Charge‐transfer‐to‐solvent absorption spectra of I−(H2O)3–5 at a finite temperature via simulation
Authors: Chiou Mong‐Feng , Sheu Wen‐Shyan 
Published: May 2017

AbstractGround‐state equilibrium Born–Oppenheimer molecular dynamics on I−(H2O)3–5 clusters at ∼200 K are performed to sample configurations for calculating the charge‐transfer‐to‐solvent (CTTS) absorption spectra for these clusters. When there are more water molecules in clusters, the calculated CTTS spectra are found to become more intense with the absorption maxima shifting to higher energies, which is in agreement with experimental results. In addition, compared with the findings for optimized structures, the absorption energies of the iodide 5p orbitals are red‐shifted at ∼200 K because, on average, the distances between the iodide and the dangling hydrogen atoms are increased at finite temperatures which weakens the interactions between the iodide and water molecules in the clusters. Moreover, the number of ionic hydrogen bonds in the clusters are also reduced. However, it is found that all dangling hydrogen atoms must be considered to obtain a good correlation between the CTTS excitation energy and the average distance between the iodide and the dangling hydrogen atoms, which indicates the existence of the strong interactions of the CTTS electron with all of the dangling hydrogen atoms.
Quantum chemical design of rotary molecular motors
Authors: Oruganti Baswanth , Wang Jun , Durbeej Bo 
Published: May 2017

AbstractThis tutorial review describes how recent quantum chemical calculations and non‐adiabatic molecular dynamics simulations have provided valuable guidelines and insights for the design of more powerful synthetic rotary molecular motors. Following a brief overview of the various types of rotary motors synthesized to date, we present computationally identified steric and electronic approaches to significantly reduce the free‐energy barriers of the critical thermal isomerization steps of chiral overcrowded alkenes, a main class of motors whose potential for many different kinds of applications is well documented. Furthermore, we describe how computational research in this field has provided new motor designs that differ from overcrowded alkenes by either (1) completing a full 360° rotation through fewer steps, (2) exhibiting more efficient photochemical steps, or (3) requiring fewer chiral features for their function, including a design that even in the absence of a stereocenter achieves unidirectional rotary motion from two Z/E photoisomerizations alone.
Ion induced controlled modifications in structural and optical properties of indium oxide thin films – studies with 25‐keV Co− and N+ beam implantations
Authors: Sethi Riti , Kaushik Priya Darshni , Aziz Anver , Siddiqui Azher M. , Kumar Pravin 
Published: May 2017

Two sets of indium oxide thin films (~150 nm) grown on quartz substrates using thermal evaporation technique were processed separately with 25‐keV Co− and N+ ions with several fluences ranging from 1.0 × 1015 to 1.0 × 1016 ions/cm2. The pristine and the ion implanted films were characterized by Rutherford backscattering spectroscopy (RBS), X‐ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM) and UV–Vis spectrometry. The RBS spectra reveal signature of only cobalt and nitrogen in accordance to their fluences confirming absence of any contamination arising due to ion implantation. An increase in the average crystallite size (from 13.7 to 15.3 nm) of Co− ions implanted films was confirmed by XRD. On the other hand, the films implanted with N+ ions showed a decrease in the average crystallite size from 20.1 to 13.7 nm. The XRD results were further verified by SEM micrographs. As seen in AFM images, the RMS surface roughness of the samples processed by both ion beams was found to decrease a bit (29.4 to 22.2 nm in Co− implanted samples and 24.2 to 23.3 nm in N+ implanted samples) with increasing fluence. The Tauc's plot deduced from UV–visible spectroscopy showed that the band gap decreases from 3.54 to 3.27 eV in Co− implanted films and increases from 3.38 to 3.58 eV for films implanted with N+ ions. The experimental results suggest that the modifications in structural and optical properties of indium oxide films can be controlled by optimizing the implantation conditions. Copyright © 2017 John Wiley & Sons, Ltd.