bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polycystic Ovary Syndrome Underdiagnosis Patterns by Individual-level and Spatial Social Vulnerability Measures
Authors: Silva Emily L , Lane Kevin J , Cheng Jay Jojo , Popp Zachary , van Loenen Breanna D , Coull Brent , Hart Jaime E , James-Todd Tamarra , Mahalingaiah Shruthi 
Published: October 2024

Abstract

Objective
To use electronic health records (EHR) data at Boston Medical Center (BMC) to identify individual-level and spatial predictors of missed diagnosis, among those who meet diagnostic criteria for polycystic ovary syndrome (PCOS).

Methods
The BMC Clinical Data Warehouse was used to source patients who presented between October 1, 2003, and September 30, 2015, for any of the following: androgen blood tests, hirsutism, evaluation of menstrual regularity, pelvic ultrasound for any reason, or PCOS. Algorithm PCOS cases were identified as those with International Classification of Diseases (ICD) codes for irregular menstruation and either an ICD code for hirsutism, elevated testosterone lab, or polycystic ovarian morphology as identified using natural language processing on pelvic ultrasounds. Logistic regression models were used to estimate odds ratios (ORs) of missed PCOS diagnosis by age, race/ethnicity, education, primary language, body mass index, insurance type, and social vulnerability index (SVI) score.

Results
In the 2003-2015 BMC-EHR PCOS at-risk cohort (n = 23 786), there were 1199 physician-diagnosed PCOS cases and 730 algorithm PCOS cases. In logistic regression models controlling for age, year, education, and SVI scores, Black/African American patients were more likely to have missed a PCOS diagnosis (OR = 1.69 [95% CI, 1.28, 2.24]) compared to non-Hispanic White patients, and relying on Medicaid or charity for insurance was associated with an increased odds of missed diagnosis when compared to private insurance (OR = 1.90 [95% CI, 1.47, 2.46], OR = 1.90 [95% CI, 1.41, 2.56], respectively). Higher SVI scores were associated with increased odds of missed diagnosis in univariate models.

Conclusion
We observed individual-level and spatial disparities within the PCOS diagnosis. Further research should explore drivers of disparities for earlier intervention.
Interobserver and intraobserver reliability of skull base angles measured on magnetic resonance images
Authors: Kizilgoz Volkan , Aydin Sonay , Aydemir Huseyin , Keles Papatya , Kantarci Mecit 
Published: October 2024

BACKGROUND
Determination of platybasia and basilar kyphosis are significant parts of routine cranial magnetic resonance (MR) interpretations. These situations may explain a patient’s symptoms or may be associated with other anomalies.
AIM
To indicate the interobserver and intraobserver reliability of the skull base angles (SBA) (Koenigsberg standard) and modified SBA (mSBA) measurement techniques.
METHODS
In total, 391 patients who had undergone cranial MR imaging were re-assessed regarding the SBA measurements. The SBA and mSBA techniques were used on MR images. Two reviewers independently measured the same angles twice within a 15-day interval, using different monitors. Intraclass correlation coefficient (ICC) was calculated to reveal the intraobserver and interobserver agreements.
RESULTS
There was an excellent agreement between reviewers regarding both angle measurements (ICC was 0.998 for SBA and mSBA). Excellent agreement levels were also observed for intraobserver measurements. ICC was 0.998 for SBA and 0.999 for mSBA for reviewer 1. ICC was 0.997 for SBA and 0.999 for mSBA according to the measurement results of reviewer 2. Higher SBA and mSBA values were observed for females compared to males. There was no correlation between SBA and age for SBA. However, a negative and low-level correlation was observed between mSBA values and age for both reviewers.
CONCLUSION
SBA and mSBA measurements indicated excellent agreement regarding interobserver and intraobserver differences. The study results showed that SBA angles were reliable measurement techniques to be used on MR images.
Traumatic isolated bilateral gluteus minimus injuries misdiagnosed as lumbar radiculopathy: A case report
Authors: Cho Hong-Man , Heo Haeryong , Jung Myung-Cheol 
Published: October 2024

BACKGROUND
The tear of the gluteus medius and minimus tendons can cause chronic buttock pain, especially in middle-aged individuals; these tears occur mostly in association with degenerative changes in the muscles and tendons. Chronic injuries are more common than acute injuries, and concurrent injuries to the gluteus medius and minimus tendons without chronic pain are rare, especially isolated injuries to both sides of the gluteus minimus; such a case has not yet been reported.
CASE SUMMARY
The authors present a case of bilateral acute traumatic injuries to the gluteus minimus during buttock strengthening exercises in a 75-year-old male patient. The patient completely returned to his pre-injury lifestyle after 8 weeks of injury, with no limitations, but the diagnosis was initially delayed due to misdiagnosis as lumbar radiculopathy, resulting in unnecessary socio-economic burden on the patient.
CONCLUSION
When treating patients who complain of hip pain, it is important to consider various causes to make a correct diagnosis.
Conversion surgery after gemcitabine and cisplatin plus durvalumab for advanced intrahepatic cholangiocarcinoma: A case report
Authors: Igata Yu , Kudo Masashi , Kojima Motohiro , Kami Shota , Aoki Keishiro , Satake Tomoyuki , Kobayashi Tatsushi , Sugimoto Motokazu , Kobayashi Shin , Konishi Masaru , Gotohda Naoto 
Published: October 2024

BACKGROUND
The combination of immune checkpoint inhibitors and chemotherapy has shown promising results for the treatment of advanced biliary tract cancer (BTC). Based on the results of the TOPAZ-1 trial, a gemcitabine and cisplatin plus durvalumab (GCD) regimen was recently approved as first-line therapy for patients with advanced BTC. However, post-GCD conversion surgery has not been previously studied. Herein, we describe a case of advanced intrahepatic cholangiocarcinoma (ICC) successfully treated with radical surgery after GCD.
CASE SUMMARY
A 65-year-old female diagnosed with advanced ICC with periductal infiltration into the hepatic hilum underwent eight cycles of GCD, followed by durvalumab maintenance treatment, with mild adverse events. Partial response was obtained. Subsequently, a conversion surgery with extended left hepatectomy and bile duct resection was performed. The resection margins were negative, and the pathological diagnosis was compatible with small duct type ICC. The patient remained disease-free for 8 months without adjuvant chemotherapy.
CONCLUSION
We describe the case of a patient who received successful conversion surgery after GCD treatment for advanced ICC.
Neuralgic amyotrophy with hourglass-like constrictions: A case report
Authors: Bang Mi-Hyeon , Song Ha-Lim , Hahn Seok , Kim Wanil , Do Hwan-Kwon 
Published: October 2024

BACKGROUND
Neuralgic amyotrophy (NA) is a rare disease with sudden upper limb pain followed by affected muscle weakness. The most commonly affected area in NA is the upper part of the brachial plexus, and the paraspinal muscles are rarely affected (1.5%), making these cases difficult to distinguish from cervical radiculopathy.
CASE SUMMARY
A 76-year-old male presented to the emergency department with left hip pain post-fall. After undergoing left femoral neck fracture surgery, he experienced sudden left shoulder pain for 10 days with subsequent left arm weakness. Cervical spine computed tomography revealed mild right asymmetric intervertebral disc bulging with a decreased C5-6disc space. Three weeks later, an electrodiagnostic study confirmed brachial plexopathy findings involving the cervical root. Magnetic resonance neurography was performed for a differential diagnosis. Contrast enhancement was identified at the upper trunk of the brachial plexus, including the C5 nerve root. A suprascapular nerve hourglass-like focal constriction (HLFC) was also identified, confirming NA. After being diagnosed with NA, the patient received 15 mg prednisolone, twice daily, for 3 weeks. Physical therapy was initiated, including left arm strengthening exercises and electrical stimulation therapy. Left shoulder muscle strength significantly improved one month after comprehensive rehabilitation.
CONCLUSION
NA's unique features like HLFC and paraspinal involvement are crucial for accurate diagnosis, avoiding confusion with cervical radiculopathy.
TAFSIR HIKAYATI AS A RESISTANCE HERMENEUTICS: Hikayat Prang Sabi’s Contribution to Holy War Literature and Quranic Studies
Authors: Fadhli Fadhli , Ichwan Moch Nur , Machasin M. 
Published: October 2024

This article will elaborate on the model of interpreting the Quran in Hikayat Prang Sabi. Guided by the text by Teungku Chiek Pante Kulu, the author analyses the data by Hans Georg Gadamer’s ideas about “Preunderstanding”, “Fusion of Horizons”, and “Historical Consciousness”. This research shows that Hikayat Prang Sabi has introduced a unique model of interpreting the Quran by adopting hikayat instruments in Acehnese culture. The author identifies this interpretation model in this research with Tafsir Hikayati. Tafsir Hikayati has contributed to constructing the Acehnese’s resistance to Dutch colonialism by bringing together two very influential spirits in Acehnese society: religion and culture. Through Tafsir Hikayati, Teungku Chiek Pante Kulu constructs a “Resistance Hermeneutics” by interpreting Islamic religious texts (the Quran) using the Acehnese cultural language (hikayat). Combining these two spirits has helped the Acehnese people accept and capture the message of resistance conveyed by Hikayat Prang Sabi so that it succeeded in awakening the spirit of ideological struggle against Dutch colonialism.[Artikel ini mengelaborasi model penafsiran Al-Quran dalam Hikayat Prang Sabi. Dengan berpedoman pada teks karya Teungku Chiek Pante Kulu, penulis menginterpretasi data dengan meminjam gagasan Hans Georg Gadamer tentang “Pra-Pemahaman”, “Perpaduan Horizon (cakrawala)”, dan “Kesadaran (keterpengaruhan) sejarah”. Penelitian ini menunjukkan bahwa Hikayat Prang Sabi telah memperkenalkan model penafsiran Al-Quran yang khas dengan mengadopsi intrumen hikayat dalam kebudayaan Aceh. Dalam penelitian ini, penulis mengidentifikasi model penafsiran tersebut dengan istilah Tafsir Hikayati. Tafsir Hikayati telah berkontribusi dalam mengkontruksi perlawanan orang Aceh terhadap kolonialisme Belanda dengan mempertemukan dua spirit yang sangat berpengaruh dalam masyarakat Aceh: agama dan budaya. Melalui Tafsir Hikayati, Teungku Chiek Pante Kulu mengonstruksi tafsir perlawanan (resistance hermeneutics) dengan melakukan interpretasi teks keagamaan Islam (Al-Quran) menggunakan bahasa kebudayaan (hikayat) yang berkembang di Aceh. Perpaduan dua spirit tersebut telah membantu orang Aceh dalam menerima dan menangkap pesan perlawanan yang disampaikan oleh Hikayat Prang Sabi sehingga berhasil membangkitkan semangat perjuangan ideologis dalam melawan penjajahan Belanda.]
Русские катойконимы глазами носителей языка: конкуренция символических ценностей
Authors: Ахметова Мария Вячеславовна 
Published: October 2024

Аннотация
В статье ставится вопрос, почему внутри локальных сообществ ведется полемика о вариантных названиях жителей (катойконимах) и в чем причины значимости той или иной аргументации участников дискуссий. Рассматриваемый материал лежит в поле языковых установок и идеологий; обыденных представлений носителей языка о языке и локальной идентичности. Выявляются принципы конструирования представлений о релевантных и нерелевантных катойконимах, актуализируемых в рамках дискурса нормативности, дискурса локальности и дискурса традиционности. Этим дискурсам соответствуют три престижных ресурса, или символических ценности (грамотность, локальная специфичность и привычность), которые для носителей языка определяют выбор того или иного варианта. Рассматриваются два кейса: дискуссии о релевантности/нерелевантности вариантных катойконимов в Старой Руссе и Тамбове; демонстрируется различное соотношение в этих дискуссиях указанных конкурирующих ценностей.
Universalizing the particulars: neoliberalizing English language teaching (ELT) through outcome-based education (OBE)
Authors: Memon Talha , Shah Waqar Ali 
Published: October 2024

Abstract
Universities, once regarded as places for producing organic intellectuals and critical thinkers, now are targets of neoliberalism, where managerialist discourses and lexis are dominant in various forms. Students and teachers are transformed into entrepreneurs, consumers and customers through such discourse and lexis. As a neoliberal variant used in education today, outcome-based education (OBE) – focus of the present study – can be viewed as one such discursive attempt on the part of the universities with an aim to perpetuate neoliberal market rationality. Through in-depth semi-structured interviews with teachers at engineering universities in Pakistan, this study examines OBE-driven ELT pedagogy using Gramsci’s hegemony as a theoretical framework. We aimed to understand how OBE-based ELT tends to transform teachers’ subjectivities into neoliberal ‘selves’, the way it impacts pedagogy and learning of the English language, and how these subjectivities are resisted. It appears that OBE-based ELT circulates market logics in the ELT pedagogy and learning by viewing English language as a skill/commodity. Student learning and teachers’ pedagogical performance indicators are based on achievement of specific outcomes. Some teachers, however, argue that OBE-led ELT deprives them of their pedagogical experiences, freedom, and conceptualizations appropriate for their pedagogical approach. We therefore advocate de-centering and deconstructing neoliberal logics in pedagogy and suggest pedagogy of becoming, critical/dialogic language pedagogy and translanguaging as possible alternatives.
A qualitative study on perceptions of adolescents’ sexual and reproductive health education in Yogyakarta, Indonesia
Authors: Sikoki Bondan , Larastiti Ciptaningrat , Suriastini Ni Wayan , Pujiastuti Setyo 
Published: October 2024

Abstract

Introduction
Sexual and reproductive health (SRH) education in Yogyakarta, Indonesia, is contentious due to societal and religious taboos in the Javanese Muslim community and being misunderstood as a potential catalyst for the premarital sex of unmarried adolescents. The existing practice of SRH education cannot guarantee reliable information about adolescent sexuality. The research aims to understand the intergenerational perception of SRH education conducted at high schools, which has not been comprehensively researched. This qualitative study was conducted in 2016 to explore the perspectives of adults and adolescents regarding school-based SRH education. Focus group discussions and individual interviews were used for data collection, while data analysis was conducted using a feminist perspective.

Content
The study identified gaps in the delivery of SRH education among Javanese Muslim, Indonesia. SRH education had not adequately addressed how adults and adolescents perceived sexuality as taboo due to moral panic about premarital sex and societal expectations placed on girls to maintain their virginity. Peer counsellors, responsible for imparting SRH information and facilitating communication with adolescents, reproduced adult moral values toward their peers, leading to a reluctance among adolescents to share their issues. Consequently, SRH education failed to reach those experiencing unwanted pregnancy or a toxic intimate relationship.

Summary and Outlook
The results of the study indicate the need to challenge intergenerational perceptions regarding sexuality and gender expectations to promote a positive gender perspective within SRH education in Indonesia.
Reproductive physiology of Indian pangolin (Manis crassicaudata) in Pothwar Plateau, Pakistan
Authors: Mahmood Tariq , Bibi Asma , Shamas Shazia , Andleeb Shaista , Akrim Faraz , Khan Bushra Nisar , Qureshi Irfan Zia , Nadeem Muhammad Sajid , Kayani Amjad Rashid , Mushtaq Muhammad , Irshad Nausheen , Noreen Shumaila 
Published: October 2024

Abstract
The Indian pangolin (Manis crassicaudata) is an “endangered” mammal species that is restricted to four range countries of Asia. The ecology and breeding behavior of Indian pangolins is poorly understood due to a lack of scientific data. Due to heavy poaching and illegal killing, the species population has declined drastically in the last decade. Considering the fact that Indian pangolin has low reproductive output, it needs special conservation measures and authentic information about its breeding ecology. We estimated concentrations of three reproductive hormones from scats using ELISA kits in male and female pangolins inhabiting the Pothwar Plateau, Pakistan, to confirm its breeding pattern in its range. Testosterone levels were found elevated from May (0.59 ng/ml) until October (1.28 ng/ml). Oestradiol levels were raised from May (0.59 pg/ml) until December (2.64 pg/ml). Progesterone concentrations were relatively low from January until March but increased from April (4.85 pg/ml) through December (14.0 pg/ml) with highest concentrations (20.13 pg/ml) in September and October. Mean hormone (testosterone, oestradiol and progesterone) concentrations were elevated in winter compared to summer (p < 0.001). The current study is the first one to quantify hormonal levels in this species, and our findings establish the breeding pattern of Indian pangolin.
Two approaches to the semantic decomposition of change of state verbs, how they differ, and why it matters
Authors: McNally Louise 
Published: October 2024

In this paper, I contrast two broad decompositional approaches to verb semantics. One, especially associated with David Dowty, involves translating verbs using a set of precisely interpreted primitive predicates such as CAUSE and BECOME, in order to facilitate semantic generalizations such as patterns of entailment between sentences. Another, with multiple origins in both temporal semantics and theories of the syntax/semantics interface (including, notably, work by Pustejovsky and Piñón), involves developing a theory of the internal part structure of the eventualities that verbs and other expressions describe; I refer to this approach, following Pianesi and Varzi, as mereotopological. These two approaches to decomposition are not, strictly speaking, incompatible, and they have sometimes been combined; however, perhaps surprisingly, comparison of them has been unsystematic. I address this gap by describing more systematically how the approaches differ from each other, illustrating with differences in the insights they offer into specific aspects of the semantics of simple change of state verbs and unselected object resultatives. I especially aim to promote interest in the development of more sophisticated, cross-linguistically applicable theories of so-calledevent structure through appeal to a wider range of notions from mereotopology.
Mitochondrial dysfunction in patients with respiratory diseases
Authors: Mishlanov V. Ju. , Chuchalin A. G. , Chereshnev V. A. 
Published: October 2024

The aim of this scientific literature review was to find new solutions to urgent problems of treating respiratory diseases and reducing the associated temporary loss of ability to work and disability. The article presents the results of the analysis of 62 scientific papers published over 23 years (2001 – 2023) on mitochondrial dysfunction (MD), new methods of its diagnosis, and ways of its correction in respiratory diseases. Disorder of the energy function of mitochondria has been identified as an urgent scientific problem of respiratory medicine. It is noted that new methods of pathogenetic therapy for common and currently difficult-to-treat diseases are being developed to solve this problem. The key section of the review is devoted to the results of studies of mitochondrial dysfunction in patients with asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and pulmonary hypertension.Conclusion. The article assesses MD diagnostic methods that are potentially applicable in real clinical practice. The results of studying the electric potential of the inner mitochondrial membrane, accumulation of active forms of oxygen, production of adenosine triphosphate in blood cells, alveocytes and epithelium of the respiratory tract, as well as bronchial smooth muscle cells, endothelium and vascular smooth muscle cells in the pulmonary artery system, determination of mitochondrial DNA in biological environments are compared. Proposed methods for the correction of MD syndrome in the clinical picture of respiratory diseases are briefly covered.
Efficacy and safety of inhaled molecular hydrogen therapy in patients with respiratory failure due to chronic obstructive pulmonary disease exacerbation in post-COVID period
Authors: Shogenova L. V. , Gufranov Kh. F. 
Published: October 2024

Molecular hydrogen (H2) is a powerful antioxidant and anti-apoptotic agent. H2 has been studied in a number of clinical studies in the recent years.The aim of this research was to investigate the efficacy and safety of H2 inhalation therapy in patients with hypoxemic and hypercapnic respiratory failure (RF) against exacerbation of chronic obstructive pulmonary disease (COPD) in the post-COVID (Corona Virus Disease 2019) period.Methods. The randomized prospective parallel comparative study included patients (n = 60: 40 men aged 71.2 ± 1.8 years, 20 women aged 70.9 ± 2.8 years) with a post-COVID-19 exacerbation of COPD complicated by hypoxemic/hypercapnic RF. The patients were divided into 2 groups: group 1 (main) (n = 30: 18 men, 12 women), group 2 (control) (n = 30: 18 men, 12 women). To maintain arterial blood saturation ≥ 90 %, patients in both groups received respiratory support (non-invasive ventilation) using the Prisma 25ST device (Lowenstein Medical, Germany) in the BiPAP S/T mode (BiLevel Positive Airway Pressure Spontaneous/Time spontaneous/forced mode 20–24/4–6 cm H2O and O2, respectively; the fractional oxygen concentration in the inhaled gas mixture was ≥ 24%). In addition to standard treatment, patients in the main group received additional H2 therapy (Suisonia device, Japan) through a nasal cannula for 90 minutes daily for 14 days.Results. In patients of the main group, a decrease in the stiffness index was detected from 14.6 ± 1.2 to 6.2 ± 0.6 m/s, and the arterial blood lactate level – from 2.84 ± 0.1 to 0.02 ± 0.1 mmol/l (p < 0.001), the calculated shunt fraction Qs/Qt (venous admixture) – from 27.21 ± 3.4 to 7.14 ± 1.23 (p < 0.01) and an increase in the following parameters: reflection index – from 42.2 ± 2.0 to 66.2 ± 4.9% (p < 0.05), virus-specific IgG level – from 134 ± 125 to 669 ± 164 (p < 0. 05), blood flow velocity in arterioles – from 473 ± 108 to 868 ± 64 μm/s (p < 0.05), blood flow velocity in venules – from 299 ± 56 to 862 ± 69 μm/s (p < 0.05), the 6-minute walk distance – from 57.1 ± 4.4 to 328.9 ± 33.7 m (p < 0.05).Conclusion. H2 inhalations were safe and increased the therapeutic effect when added to standard therapy for patients with hypoxemic and hypercapnic RF during exacerbation of COPD in the post-COVID period.