bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cooperative grey games and an application on economic order quantity model
Authors: Olgun Mehmet Onur , Alparslan Gök Sırma Zeynep , Özdemir Gültekin 
Published: May 2016

Purpose
– The purpose of this paper is to extend the results of Meca et al. (2004) depending on the grey information revealed by the individual firms.

Design/methodology/approach
– The authors introduce cooperative grey games and focus on sharing ordering cost rule (SOC-rule) to distribute the joint cost.

Findings
– In this study, the authors introduce a model, where inventory costs are assumed as grey numbers instead of crisp or stochastic ones studied in literature. At first, grey numbers and classical cooperative inventory games are recalled. Then, cooperative grey games are introduced and related results are given. Finally, an application is performed for three shotgun companies in Turkey.

Originality/value
– It is an effective approach for theoretical analysis of systems with imprecise information and incomplete samples. Therefore, grey system theory, rather than the traditional probability theory and fuzzy set theory, is better suited to model the inventory problems by using cooperative game theory. To the best of the knowledge no study exists modeling inventory situations by using cooperative grey games. From this point of view this study is a pioneering work on a promising topic.
Ontology-based representation of meteorological disaster system and its application in emergency management
Authors: Zhang Fushen , Zhong Shaobo , Yao Simin , Wang Chaolin , Huang Quanyi 
Published: May 2016

Purpose
– The purpose of this paper is to make research on causing mechanism of meteorological disaster as well as the components of meteorological disaster system and their semantic relationships. It has important practical significance due to the urgent need of further providing support for pre-assessment of influences of disastrous weather/climate events and promoting the level of emergency management.

Design/methodology/approach
– This paper analyses the occurrence regulations and components of meteorological disasters and proposes the concept of meta-action. Ontology modelling method is adopted to describe the components and relationships among different parts comprising meteorological disaster system, and semantic web rule language is selected to identify the implicit relationships among the domain knowledge explicitly defined in ontology model. Besides, a case is studied to elaborate how to provide logic and semantic information support for comprehensive risk assessment of disastrous weather/climate events based on rule-based ontology reasoning method. It proves that ontology modelling and reasoning method is effective in providing decision makings.

Findings
– This paper provides deep analyses about causing mechanisms of meteorological disasters, and implements information fusion of the components of meteorological disaster system and acquisition of potential semantic relations among ontology components and their individuals.

Originality/value
– In this paper, on the basis of analysing the disaster-causing mechanisms, the meteorological disaster ontology (MDO) model is proposed by using the ontology modelling and reasoning method. MDO can be applied to provide decision makings for meteorological departments.
Organizational citizenship behaviors and employee depressed mood, burnout, and satisfaction with health and life
Authors: Baranik Lisa E. , Eby Lillian 
Published: May 2016

Purpose
– Using mood regulation theories and the broaden-and-build theory of positive emotions, the purpose of this paper is to hypothesize that the relationship between organizational citizenship behaviors aimed at individuals (OCB-Is) and depressed mood, burnout, and satisfaction with life and health would be mediated by positive affect.

Design/methodology/approach
– Lagged data were collected from employee-supervisor dyads.

Findings
– OCB-Is were related to positive affect, and positive affect was positively related to subsequent reports of life satisfaction and general health satisfaction, and negatively related to burnout and depressed mood. Positive affect mediated the relationship between OCB-Is and life satisfaction, general health satisfaction, and depressed mood but not burnout. An alternative reverse causality mediation model ruled out the possibility that OCB-Is mediated the relationship between positive affect and the employee outcomes.

Originality/value
– These findings lend support for OCBs being an antecedent of mood, rather than vice versa.
Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis
Authors: Hirsch M , Duffy JMN , Davis CJ , Nieves Plana M , Khan KS ,   on behalf of the International Collaboration to Harmonise Outcomes and Measures for Endometriosis
Published: May 2016

BackgroundThe development of a non‐invasive and accurate diagnostic biomarker for endometriosis is urgently needed.ObjectiveEvaluate the diagnostic accuracy of serum cancer antigen 125 (CA 125) for endometriosis.Search strategyWe searched EMBASE, MEDLINE, and Web of Science from inception to January 2016.Selection criteriaDiagnostic accuracy studies of serum CA 125 (index test) for histologically confirmed endometriosis (reference standard) were included.Data collection and analysisTwo authors independently selected trials, extracted study characteristics and data. Methodological quality was assessed using Quality Assessment of Comparative Diagnostic Accuracy Studies (QUADAS‐2) checklist.Main resultsTwenty‐two studies (16 cohort, six case‐control), 3626 participants, were identified. Bivariate hierarchical models were used to pool accuracy data of 14 studies (2920 participants) using CA 125 ≥ 30 units/ml. Pooled specificity was 93% (95% CI 89–95%) and sensitivity 52% (95% CI 38–66%). CA 125 was significantly more sensitive for the diagnosis of moderate or severe endometriosis compared with minimal disease (63%, 95% CI 47–77% versus 24%, 95%CI 19–32%, P‐value = 0.001).ConclusionsCA 125 performs well as a rule‐in test facilitating expedited diagnosis and ensuring investigation and treatment can be confidently tailored for the management of endometriosis. Unfortunately, a negative test, CA 125 < 30 units/ml, is unable to rule out endometriosis.Tweetable abstractBlood test CA 125: a rule‐in test for the diagnosis of women presenting with symptoms of endometriosis
Small activating ribonucleic acid reverses tyrosine kinase inhibitor resistance in epidermal growth factor receptor‐mutant lung cancer by increasing the expression of phosphatase and tensin homolog
Authors: Li Meng , Peng Zhongmin , Ren Wangang , Wang Zhou 
Published: May 2016

BackgroundEpidermal growth factor receptor‐tyrosine kinase inhibitors (TKI‐EGFRs) present a new prospect for the treatment of lung cancer. However, in clinical application, the majority of patients become TKI resistant within a year. More and more studies have shown that a loss of phosphatase and tensin homolog (PTEN) expression is associated with TKI resistance. An alternative method of upregulating PTEN expression may reverse TKI resistance.MethodsWe designed five candidate small activating ribonucleic acids (saRNAs) to target PTEN, and transfected them into H‐157 cells to screen out functional saRNA. We used reverse transcriptase‐polymerase chain reaction and Western blot to evaluate the effect of saRNA to PTEN expression. We then analyzed the growth and apoptosis of cells transfected with saRNA under the treatment of TKI to investigate whether saRNAs can reverse TKI resistance by upregulating PTEN expression.ResultsThe functional saRNA we designed could upregulate PTEN expression. The H‐157 cells transfected with saRNA grew slower in the presence of TKI drugs than the cells that were not transfected with saRNA. The apoptosis rate was also obviously higher.ConclusionsOur study proves that loss of PTEN expression is an important mechanism of TKI resistance. It is possible to control TKI resistance by upregulating PTEN expression using RNA activation technology.
Skin disease of penis and male genitalia is linked to atopy and circumcision: caseload in a male genital dermatology clinic
Authors: Elakis Joshua Angelo , Hall Anthony P. 
Published: May 2016

AbstractBackground/ObjectivesMale genital dermatoses are a common and underappreciated cause of morbidity. Its prevalence and the characteristics of patients presenting with these conditions are poorly understood. The aim of the study was to ascertain which dermatoses were referred to the Male Genital Dermatology Clinic in Melbourne, Australia and to determine whether circumcision and atopy are associated with male genital skin disease.MethodThis was a retrospective review of 331 new patients who attended the clinic from 2004 to 2012. Descriptive statistics were obtained to determine the frequency of diagnoses made in the clinic and to record the proportions of circumcised and atopic patients.ResultsThe most common primary diagnoses were irritant contact dermatitis (n = 67), dysaesthesia (n = 60), psoriasis (n = 31), lichen sclerosus (n = 28), unknown (n = 19), genital warts (n = 18), normal anatomic variant (n = 17), other infection (n = 17), eczema (n = 16) and lichen planus (n = 16). For the 10 most commonly observed conditions, more than 70% of patients were uncircumcised and more than 69% of these patients had a history of atopy.ConclusionsThe diagnoses made were described, including their associations with non‐circumcision and atopy. Several of these observations have not been recognised before in the literature. We discuss lessons learned in the management of male genital disease and its psychosocial impact.
Late presentation of generalised bullous pemphigoid‐like reaction in a patient treated with pembrolizumab for metastatic melanoma
Authors: Parakh Sagun , Nguyen Rebecca , Opie Jacinta M , Andrews Miles C 
Published: May 2016

AbstractDermatological toxicity is one of the most commonly reported immune‐related adverse events in patients receiving checkpoint inhibitor immunotherapy. We report the gradual development of a widespread bullous pemphigoid‐like reaction in a metastatic melanoma patient 8 months after commencing treatment with the programmed‐death‐1 (PD‐1) inhibitor pembrolizumab, requiring prolonged corticosteroid therapy. This case highlights the potential for insidious and late development of severe cutaneous toxicity following PD‐1 inhibitor therapy and suggests that even prolonged immunosuppression may not necessarily compromise the efficacy of PD‐1 inhibition in advanced melanoma.
Perspectives on avian stem cells for poultry breeding
Authors: Kagami Hiroshi 
Published: May 2016

AbstractStem cells have prulipotency to differentiate into many types of cell lineages. Recent progress of avian biotechnology enabled us to analyze the developmental fate of the stem cells: embryonic stem cells / primordial germ cells (PGCs). The stem cells were identified in the central area of the area pellucida of the stage X blastoderms. These cells could be applied for production of germline chimeras and organ regeneration. Generation of medical substrate in transgenic chickens has considerable interests in pharmaceuticals. Sex alteration of the offspring should be enormously beneficial to the poultry industry. Fertilization of the sex‐reversed sperm could lead to sexual alteration of the offspring. These strategies using stem cells / PGCs should be one of the most powerful tools for future poultry breeding.
Microtubule assembly crucial to bovine embryonic development in assisted reproductive technologies
Authors: Hochi Shinichi 
Published: May 2016

AbstractCentrosome integrity and microtubule network are crucial to the events around fertilization, including pronuclear development, migration and fusion, and the first mitotic division. The present review highlights the importance of bull spermatozoal centrosomes to function as a microtubule‐organizing center for successful fertilization and the subsequent embryonic development. Spermatozoal centrosomes need to be blended with ooplasmic pericentriolar materials accurately to nucleate and organize the sperm aster. Dysfunction of the spermatozoal centrosomes is associated with fertilization failure, which has been overcome with supplemental stimuli for oocyte activation following intracytoplasmic sperm injection in humans. Even though the spermatozoal centrosomes are functionally intact, abnormal sperm aster formation was frequently observed in vitrified‐warmed bovine oocytes, with delayed pronuclear development and migration. Treatment of the post‐warm oocytes with Rho‐associated coiled‐coil kinase inhibitor or α‐tocopherol inhibited the incidence of the abnormal aster formation, resulting in higher blastocyst yields following in vitro fertilization and culture. Thus, understanding of centrosomal function made it possible to improve the performance of advanced reproductive technologies.
Piroxicam and doxycycline treatment for an oral squamous cell carcinoma in an inshore bottlenose dolphin (Tursiops aduncus)
Authors: March DT , Blyde DJ , Bossart GD , Begg AP , Taylor DP , McClure V 
Published: May 2016

BackgroundThe virus family Papillomaviridae has been documented in a wide range of animal species and can cause benign and malignant proliferative lesions. The presence of concurrent lingual papillomas and squamous cell carcinomas (SCC) in cetaceans has also been documented in both wild and captive populations, suggesting malignant transformation of benign papilloma to SCC may occur in this species.Case reportIn 2008, a 38‐year‐old captive male inshore bottlenose dolphin (Tursiops aduncus) was diagnosed with papillomatous lesions on the intermandibular frenulum rostral to the tongue and an infiltrative SCC of the soft palate following biopsy and histological analysis. A treatment regimen of piroxicam and doxycycline was initiated with misoprostol as a gastroprotectant. The treatment resulted in a marked reduction in tumour size and reversible hepatotoxicosis. Subsequent biopsies revealed the presence of SCC in the oral cavity; however, the disease remains stable at the time of writing.ConclusionTo the best of our knowledge, this case is the first report of piroxicam and doxycycline used to treat SCC in a bottlenose dolphin. The treatment was successful in reducing the clinical presentation of the disease.
Redo buccal mucosa graft urethroplasty: success rate, oral morbidity and functional outcomes
Authors: Rosenbaum Clemens M. , Schmid Marianne , Ludwig Tim A. , Kluth Luis A. , Dahlem Roland , Fisch Margit , Ahyai Sascha 
Published: May 2016

ObjectivesTo determine the success rate, oral morbidity and functional outcomes of redo buccal mucosa graft urethroplasty (BMGU) for treatment of stricture recurrence after previous BMGU.Patients and MethodsWe included 50 patients who underwent redo BMGU between February 2009 and September 2014. Patients' charts and non‐validated questionnaires were reviewed. The primary endpoint was success rate, defined as stricture‐free survival. Stricture recurrence was defined as any postoperative claims of catheterization, dilatation, urethrotomy or repeat urethroplasty, or a maximum urinary flow rate <15 mL/s, and a stricture was consecutively verified in a combined cysto‐urethrogram or cystoscopy at annual follow‐up visit. The secondary endpoint was oral morbidity. Additional endpoints were erectile function, urinary continence and patients' satisfaction.ResultsRedo BMGU was performed for bulbar (71.4%) or penile (28.6%) recurrent strictures. The mean (median; range) follow‐up was 25.6 (15.5; 3–70) months. Stricture recurrence occurred in 18.0% of patients within a mean (median; range) of 13.8 (9.0; 3–36) months. Stricture‐free survival at 12, 24 and 36 months was 91.2, 86.2 and 80.8%, respectively. The majority of the patients (97.0%) reported no or only mildly changed salivation or problems in opening of the mouth. Severe or very severe oral numbness occurred in 13.5% of patients. Oral problems in daily life were a moderate or severe burden to 13.6 and 2.7% of the patients, respectively, while 75.0% of the patients reported improved quality of life compared with preoperative status.ConclusionsThe success rate and oral morbidity of redo BMGU are almost the same as outcomes of primary BMGU. Oral numbness was the most frequently reported oral disorder.
Deciphering the origin of cyclical gravel front and shoreline progradation and retrogradation in the stratigraphic record
Authors: Armitage John J. , Burgess Peter M. , Hampson Gary J. , Allen Philip A. 
Published: May 2016

AbstractNearly all successions of the near‐shore strata exhibit cyclical movements of the shoreline, which have commonly been attributed to cyclical oscillations in relative sea level (combining eustasy and subsidence) or, more rarely, to cyclical variations in sediment supply. It has become accepted that cyclical change in sediment delivery from source catchments may lead to cyclical movement of boundaries such as the gravel front, particularly in the proximal segments of sediment‐routing systems. In order to quantitatively assess how variations in sediment transport as a consequence of change in relative sea‐level and surface run‐off control stratigraphic architecture, we develop a simple numerical model of sediment transport and explore the sensitivity of moving boundaries within the sediment‐routing system to change in upstream (sediment flux, precipitation rate) and downstream (sea level) controls. We find that downstream controls impact the shoreline and sand front, while the upstream controls can impact the whole system depending on the amplitude of change in sediment flux and precipitation rate. The model implies that under certain conditions, the relative movement of the gravel front and shoreline is a diagnostic marker of whether the sediment‐routing system experienced oscillations in sea level or climatic conditions. The model is then used to assess the controls on stratigraphic architecture in a well‐documented palaeo‐sediment‐routing system in the Late Cretaceous Western Interior Seaway of North America. Model results suggest that significant movement of the gravel front is forced by pronounced (±50%) oscillations in precipitation rate. The absence of such movement in gravel front position in the studied strata implies that time‐equivalent movement of the shoreline was driven by relative sea‐level change. We suggest that tracking the relative trajectories of internal boundaries such as the gravel front and shoreline is a powerful tool in constraining the interpretation of stratigraphic sequences.
Detrital zircons as palaeodrainage indicators: insights into southeastern Gondwana from Permian basins in eastern Australia
Authors: Shaanan Uri , Rosenbaum Gideon 
Published: May 2016

AbstractRadioisotope geochronology of detrital grains coupled with quantitative classification of grain morphology can provide valuable insight into the history of sediment transportation and recycling. Here we present ca. 750 new concordant U‐Pb ages from detrital zircon grains from a relatively understudied Permian sedimentary succession in the New England Orogen (eastern Australia), coupled with values of abrasion that provides a proxy for the relative source‐to‐sink distance. We show that cumulative proportion curves for age groups that correspond to plausible source regions provide insights into the palaeodrainage, even if the basin stratigraphy is relatively poorly constrained. This approach is particularly suitable for investigating complex depositional systems that received inflow from different provenance, such as back‐arc and intra‐cratonic basins. Using the example from eastern Australia, our results show that during the Early Permian, a large regional fluvial system transported detritus from continental Gondwana across the landscape of the former active continental margin (New England Orogen) and the simultaneously developing East Australian Rift System. In addition, a local drainage system mobilised detritus within the New England Orogen. Our new constraints for the Early Permian palaeogeography support the idea that the Lower Permian successions of the southern New England Orogen were deposited in a back‐arc region that was likely linked to a retreating subduction zone.
Fostering student mental well‐being through supportive learning communities
Authors: Conradson David 
Published: May 2016

Key Messages

The proportion of contemporary university students experiencing mental distress appears to be increasing.
The development of supportive learning communities is a preventative and collectively oriented response to student mental distress, and complements the individually focused work of mental health professionals.
Three relatively common pedagogical practices within Geography—group work, residential fieldwork, and reflective assignments—can be used to develop supportive learning communities.
Two‐Year‐Olds Distinguish Pretending and Joking
Authors: Hoicka Elena , Martin Catriona 
Published: May 2016

Although children understand intentions to joke and pretend by 2 or 3 years, it is unclear whether they distinguish these intentional acts. Using a normativity paradigm, this study found (N = 72) 2‐year‐olds protest against jokes more than pretending, suggesting, for the first time, they distinguish these acts. Furthermore, toddlers protested more generally after pretend than literal or joke contexts but only if intentional cues were used. Additionally, children objected more to joking than pretending after pretend and literal contexts but not after joke contexts. Thus, toddlers distinguish the intentional nature of pretending and joking. Furthermore, a pretend intentional context establishes specific rules to be followed, whereas a joke intentional context allows an open space to perform various types of acts.
Protein Kinases Alter the Allosteric Modulation of the Serotonin Transporter In Vivo and In Vitro
Authors: Mnie‐Filali Ouissame , Lau Thorsten , Matthaeus Friederike , Abrial Erika , Delcourte Sarah , El Mansari Mostafa , Pershon Alan , Schloss Patrick , Sánchez Connie , Haddjeri Nasser 
Published: May 2016

SummaryAimStudies using S‐ and R‐enantiomers of the SSRI citalopram have shown that R‐citalopram exerts an antagonistic effect on the efficacy of the antidepressant S‐citalopram (escitalopram) through an interaction at an allosteric modulator site on the serotonin transporter (SERT). Here, we show that protein kinase signaling systems are involved in the allosteric modulation of the SERT in vivo and in vitro.MethodsWe assessed the effects of nonspecific protein kinase inhibitor staurosporine in the action of escitalopram and/or R‐citalopram using electrophysiological and behavioral assays in rats and cell surface SERT expression measures in serotoninergic cells.ResultsAcute administration of R‐citalopram counteracted the escitalopram‐induced suppression of the serotonin (5‐HT) neuronal firing activity and increase of the head twitches number following L‐5‐hydroxytryptophan injection. Importantly, these counteracting effects of R‐citalopram were abolished by prior systemic administration of staurosporine. Interestingly, the preventing effect of staurosporine on 5‐HT neuronal firing activity was abolished by direct activation of protein kinase C with phorbol 12‐myristate 13‐acetate. Finally, in vitro, quantification of the amount of cell surface‐expressed SERT molecules revealed that R‐citalopram prevented escitalopram‐induced SERT internalization that was completely altered by staurosporine.ConclusionTaken together, these results highlight for the first time an involvement of protein kinases in the allosteric modulation of SERT function.