bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of WO3 Content in Phosphated Tungsten‐Zirconium Oxide Catalysts on the Catalytic Pathways of Glycerol Transformation
Authors: Vlasenko Nina V. , Kosmambetova Gulnara R. , Senchylo Eugenia V. , Kúš Peter , Veltruská Kateřina , Strizhak Peter E. 
Published: October 2024

AbstractThe catalytic performance of phosphate‐stabilized WOx‐ZrO2 compositions in gas‐phase glycerol dehydration has been investigated. Results show that varying WO3 concentrations direct the process towards either acrolein or allyl alcohol formation. Catalysts with low WOx content exhibit strong Lewis acid sites (Zr4+ and W6+), where these metal ions likely function as redox sites, facilitating glycerol hydrogenolysis to produce allyl alcohol. Higher WOx concentrations (exceeding 20 wt %) lead to the shielding of some W6+ and Zr4+ sites by polytungstate surface complexes, which are strong Brønsted acid sites. This alteration promotes glycerol dehydration through the removal of two water molecules, thereby shifting the selectivity towards acrolein formation.
CircRNome‐wide characterisation reveals the promoting role of circAATF in anti‐PD‐L1 immunotherapy of gallbladder carcinoma
Authors: Wang Yueqi , Li Shengli , Bo Xiaobo , Li Yuan , Wang Changcheng , Nan Lingxi , Zhang Dexiang , Liu Houbao , Zhang Jiwei 
Published: October 2024

AbstractCircular RNAs (circRNAs) have been shown to play important roles in tumour development and tumour immunology. However, genome‐wide characterisation of circRNAs and their roles in the immunology and immunotherapy of gallbladder carcinoma (GBC) has been lacking. We present a comprehensive characterisation of the circRNA landscape in GBC, revealing GBC‐specific circRNAs. Our analysis found that circRNAs are significantly enriched in cell proliferation and are involved in cancer‐related hallmarks. In particular, circAATF was upregulated in GBC, which was positively correlated with AATF mRNA expression, and promoted GBC cell growth. Through integrating computational and experimental approaches, we revealed that circAATF is positively associated with the CD4+ T cell abundance and PD‐L1 level, and enhances the clinical benefits of anti‐PD‐L1 immunotherapy for GBC. We further demonstrate that circAATF elevates the PD‐L1 level by activating phosphorylated AKT and acting as a sponge for miR‐142‐5p. CircAATF is positively associated with CD4+ T cells and PD‐L1 levels and shows potential to aid anti‐PD‐L1 immunotherapy for GBC. Our study provides insights into roles of circAATF in the tumour development and immunology of GBC and accelerates the development of therapeutic strategies for GBC immunotherapy.Highlights
We present a comprehensive characterisation of circRNA landscape in gallbladder carcinoma (GBC).
CircAATF is positively associated with CD4+ T cell abundance and PD‐L1 expression and is shown to promote PD‐L1 treatment in mouse model.
CircAATF can elevate PD‐L1 level through phosphorylated AKT and linear AATF, which upregulates PD‐L1 by acting as a sponge of miR‐142‐5p.
Social genomics, cognition, and well‐being during the COVID‐19 pandemic
Authors: Bateman James R. , Krishnamurthy Sudarshan , Quillen Ellen E. , Waugh Christian E. , Kershaw Kiarri N. , Lockhart Samuel N. , Hughes Timothy M. , Seeman Teresa E. , Cole Steve W. , Craft Suzanne 
Published: October 2024

AbstractINTRODUCTIONAdverse psychosocial exposure is associated with increased pro‐inflammatory gene expression and reduced type‐1 interferon gene expression known as the conserved transcriptional response to adversity (CTRA). CTRA is not well‐studied in cognitive impairment but may contribute to late‐life cognitive decline.METHODSWe examined perceived stress, loneliness, well‐being, and the impact of coronavirus disease 2019 (COVID‐19) and the relationship to the expression of genes associated with the CTRA. Mixed‐effect linear models were used to quantify associations between psychosocial variables and CTRA gene expression.RESULTSEudaimonic well‐being (EWB) was inversely associated with CTRA gene expression in participants with both normal cognition (NC) and mild cognitive impairment (MCI). Self‐reported coping strategies differed by cognitive status and variably impacted CTRA gene expression.DISCUSSIONEWB is an important correlate of stress, even in people with MCI. The prodromal cognitive decline appears to moderate the significance of coping strategies as a correlate of CTRA gene expression.Highlights
Conserved transcriptional response to adversity (CTRA) gene expression is higher with lower eudaimonic well‐being.
Eudaimonic well‐being was important in both participants with normal cognition and those with mild cognitive impairment.
Coping strategies and impact on CTRA gene expression differed by cognitive status.
Loneliness in a population with relatively low loneliness scores did not impact CTRA gene expression.
Gypsum Binder With Increased Water Resistance Derived From Membrane Water Desalination Waste
Authors: Romanovski Valentin , Moskovskikh Dmitry , Tan Hongbin , Kuskov Kirill , Volodko Sergey , Akinwande Abayomi Adewale , Periakaruppan Rajiv , Kong Fanyue , Ma Xiaoling , Yang Feihua , Kamarou Maksim 
Published: October 2024

ABSTRACTA method has been developed for separating a mixture of calcium, magnesium and sodium sulfates obtained through the interaction of sulfuric acid and waste from the water purification process generated by using membrane filters. The primary goal of this method is to extract gypsum and produce gypsum‐based binders. Patterns were identified regarding how various types, ratio and quantities of additives: blast furnace slag, granite screenings, portland cement, electric steel smelting slag affect the water‐gypsum ratio, strength properties, and water resistance of high‐strength gypsum binders. It was found that adding a single‐component additive specifically to enhance water resistance does not significantly impact these properties. Complex additives have been developed based on Portland cement, granulated blast furnace slag, electric furnace slag, expanded clay dust, and granite screenings of various fractions. These additives are designed to maximize the water resistance of high‐strength gypsum binder based on synthetic calcium sulfate dihydrate. As a result, the water resistance coefficient increased from 0.45 to 0.52. Additionally, a technological block diagram of the process has been proposed.
Synergistic role of prebiotics and probiotics in gut microbiome health: Mechanisms and clinical applications
Authors: Kumari Tapasya , Bag Kshirod Kumar , Das Amit Baran , Deka Sankar Chandra 
Published: October 2024

AbstractPrebiotic and probiotic usage has exploded, with most formulations promoting gastrointestinal and immunological benefits. Prebiotics modulate the gut microbiota, as a result, short‐chain fatty acids are released into the bloodstream. Prebiotics have immunomodulatory properties that reduce inflammation while enhancing immune responses and boosting gut health. The potential of probiotics has shown steady expansion in the digestive system, metabolic balance, and vaginal health. Probiotics offer therapeutic and preventative strategies for a range of human diseases. The in vitro studies suggested the delivery matrix might influence their effects through physicochemical interactions with molecular and cellular structures as well as modifications in cellular expression. Dietary fibers and polyphenols both contribute significantly to human health protection and can ferment in the gut microbiota to create butyrate. This comprehensive review aims to highlight the probiotics and prebiotics, and provide evidence to support their use in preventive and therapeutic medicine. It is anticipated that it will help the clinical and preclinical research to look into the effects of inclusion and processing on their activity in different food delivery formulations. There are potential opportunities needed to enhance immunological and digestive health by comprehending and using the interaction between the gut microbiota and the immune system in our diet.
Health risk assessment of heavy metals in black tea infusion by Monte Carlo simulation
Authors: Esfarjani Fatemeh , Rouzbahani Mohammad , Behbahan Seyed Ehsan Beladian , Shahbazpour Narges , Moslemi Masoumeh , Abedi Abdol‐Samad 
Published: October 2024

AbstractTea leaves and their infusion have been interested in the populations because of their therapeutic and relaxing effects. However, tea plant is prone to heavy metals' bioaccumulation. Regarding the high consumption of tea infusion, concentration of arsenic, cadmium, and lead in black tea infusion was determined by inductively coupled plasma mass spectrometry. Tea infusion was prepared by addition of 45 mL deionized water to 1 g tea leaves followed by heating at 90°C for 10 min. After analysis, carcinogenic and noncarcinogenic risks of heavy metals were investigated by Monte Carlo simulation in two age groups of children and adults younger and older than 15 years old, respectively. According to the results, Hazard Quotient (HQ) of three heavy metals in both children and adults was equal and lower than 0.01. Furthermore, incremental lifetime cancer risk (ILCR) of arsenic in Iranian black tea consumers (<1.5 × 10−6) and lead in all consumers (about 2.55 × 10−7) was within the acceptable range introduced by US EPA (≤10−6). ILCR of arsenic in children and adults consuming foreign tea infusion was within the range of 10−6–10−4. Our further investigation revealed that the highest area (75%–85%) of cumulative frequency distribution for arsenic ILCR in foreign tea consumers was related to ILCR ≤10−5 which is the acceptable range determined by the World Health Organization. Therefore, there was no serious concern about the intake of heavy metals by tea infusion in Iranian children and adults.
Identification of Whey Protein‐Derived Anti‐Obesity Peptides Through 3T3‐L1 Adipocyte Differentiation Assay
Authors: Hirose Yuma , Kurimoto Masaki , Yuda Naoki , Tanaka Miyuki 
Published: October 2024

ABSTRACTWhey proteins are a rich source of bioactive peptides. Whey protein hydrolysate (WPH) can effectively improve metabolic syndrome and reduce the risk of obesity. Bioactive peptides isolated from various food sources exhibit anti‐obesity effects. However, few reports are available on the identification of anti‐obesity peptides from whey protein. In this study, we aimed to identify anti‐obesity peptides from whey protein. Our findings revealed that WPH suppressed the accumulation of lipid droplets in 3T3‐L1 adipocytes. Anti‐obesity peptides in WPH were identified using amino acid sequencing and LC–MS analysis. Then, the inhibitory effects of the synthetic peptides on adipogenesis were assessed through Oil Red O staining. Two peptides were identified as anti‐adipogenic: LDQW and LKPTPEGDLEIL. Subsequently, real‐time PCR analysis found that several adipogenesis‐related genes, such as peroxisome proliferator‐activated receptor γ, were downregulated in the treatment with these peptides. Furthermore, LDQW and LKPTPEGDLEIL decreased the mRNA expression levels of stearoyl‐coenzyme A desaturase 1 and increased carnitine palmitoyl transferase 1α expression in 3T3‐L1 adipocytes. These findings indicate that LDQW and LKPTPEGDLEIL have anti‐obesity properties and may be beneficial for treating metabolic diseases. This study provides a reference basis for developing new techniques to prevent obesity and related diseases.
A Specific Collagen Hydrolysate Improves Postprandial Glucose Tolerance in Normoglycemic and Prediabetic Mice and in a First Proof of Concept Study in Healthy, Normoglycemic and Prediabetic Humans
Authors: Grasset Estelle , Briand François , Virgilio Nicolina , Schön Christiane , Wilhelm Manfred , Cudennec Benoit , Ravallec Rozenn , Aboubacar Hairati , Vleminckx Sara , Prawitt Janne , Sulpice Thierry , Gevaert Elien 
Published: October 2024

ABSTRACTIn response to nutrients, intestinal L‐ and K‐cells naturally secrete glucagon‐like peptide 1 (GLP‐1). GLP‐1 regulates postprandial blood glucose by increasing insulin secretion, slowing down gastric emptying and inducing satiety. A selection of specifically developed collagen hydrolysates was screened for their ability to enhance natural GLP‐1 production in vitro. The best performing hydrolysate, H80 (Nextida GC), was orally administered at different doses to lean, normoglycemic mice and overweight, prediabetic mice. Lean mice were acutely challenged 45 min before an oral glucose load. While daily supplemented for 6 weeks, prediabetic mice were acutely challenged at day 21 and 34. Oral glucose tolerance, plasma insulin and GLP‐1 levels were assessed, and a gastric emptying assay performed in prediabetic mice. H80 significantly lowered the blood glucose response in lean and prediabetic mice, at a 4 g/kg dose (−25% and −36%, respectively), compared to vehicle. In chronically supplemented, prediabetic mice, acute H80 administration slowed down gastric emptying (−60%) after 21 days and increased plasma insulin (+166%) after 35 days of supplementation. H80 increased plasma active GLP‐1 in lean (+217%) and prediabetic (+860%) mice. Overall, the data indicate that the specific collagen hydrolysate, H80, has significant GLP‐1‐mediated effects on oral glucose tolerance in lean and prediabetic mice. Furthermore, effects on postprandial glucose tolerance were evaluated in a small, human, proof of concept study. H80 reduced the postprandial glucose response at a 5 g dose in healthy, normoglycemic and prediabetic participants. Oral supplementation with H80 might thus be a promising strategy to maintain normal glucose tolerance.
Prevalence of urinary incontinence in postpartum women and physiotherapy interventions applied: An integrative review
Authors: Koomson Gifty , Mgolozeli Siyabulela Eric , Mshunqane Nombeko 
Published: October 2024

AbstractObjectiveThis integrative review identified studies that reported the prevalence of physiotherapeutic interventions for urinary incontinence among postpartum women.MethodsThis is an integrative literature review study. We used the integrative literature review framework proposed by Whittemore and Knafl to search for relevant literature.Search StrategyThe search strategy for electronic databases was developed from the research question and definitions of key concepts, assisted by the librarian. Databases that were searched include Google Scholar, Medline (PubMed), CINAHL, and the Joanna Briggs Institute databases. Both qualitative and quantitative studies that met the inclusion criteria were included. We used the CASP tool to assess the quality of selected papers.Data Collection and AnalysisThe included articles were thematically analyzed. Thirty‐six papers met the inclusion criteria for the review. Six themes emerged from the analysis: prevalence of postpartum UI; risk factors for postpartum UI; antenatal pelvic floor muscle training; conservative treatment and quality of life; experiences of postpartum women with UI; and possible coping strategies adopted by women. Most of the articles were quantitative studies (80.5%); 16.6% were qualitative and 2.7% adopted mixed methods.ConclusionsUrinary incontinence is common in postpartum women. Antenatal pelvic floor muscle training is protective against postpartum UI and should be the first‐line treatment option.
Does infection with COVID‐2019 during labor increase the risk for obstetric anal sphincter injuries?
Authors: Saban Alla , Leybovitz‐Haleluya Noa , Hershkovitz Reli , Geva Yael , Weintraub Adi Y. 
Published: October 2024

AbstractObjectiveTo investigate the association between coronavirus disease 2019 (COVID‐19) infection during the peripartum period and obstetric anal sphincter injuries (OASIS).MethodsA retrospective cohort study was conducted, including all singleton vaginal deliveries and cesarean deliveries due to failed vacuum extraction, between June 2020 and January 2022 at a large tertiary medical center. OASIS complication during childbirth was compared between women with and without peripartum diagnosis of COVID‐19, defined as a positive polymerase chain reaction test obtained within 1 week before delivery or up to 3 days after delivery. Universal screening for COVID‐19 was implemented. A logistic regression model was used to adjust for confounding variables.ResultsThe study included 22 911 women, among whom 468 (2.0%) tested positive for COVID‐19 and 22 443 women had no COVID‐19 diagnosis. After adjusting for confounding variables, peripartum infection with COVID‐19 was found to be independently associated with OASIS (adjusted odds ratio 4.38, 95% confidence interval 2.00–9.61; P < 0.001).ConclusionInfection with COVID‐19 during the peripartum period significantly increases the risk for OASIS by more than fourfold. These findings emphasize the importance of understanding the impact of COVID‐19 on birth complications, such as OASIS, to improve public health measures and enhance obstetric outcomes during pandemics.
Cystic Neutrophilic Granulomatous Mastitis Mimicking Breast Cancer: A Case Report
Authors: Shijian Xu , Zhe Hong 
Published: October 2024

ABSTRACTCystic neutrophilic granulomatous mastitis (CNGM) is a rare inflammatory breast disease, with a distinct histological pattern characterized. Although it shares clinical and radiological features with other types of granulomatous mastitis, it can sometimes be difficult to distinguish from breast cancer. We report a case of CNGM misdiagnosed as malignant.
The role of radial head morphology in proximal radioulnar joint congruency during forearm rotation
Authors: Zhang Hailong , Yang Guang , Lu Yi 
Published: October 2024

AbstractPurposeCongruency of the proximal radioulnar joint (PRUJ) is important in the rotation of the forearm while any compromise would significantly impair the elbow function. The purpose of this study is to determine the morphological features of the radial head and investigate its role in the congruency of the PRUJ during forearm rotation. The hypothesis is that the PRUJ is more congruent in the maximal pronation and supination positions than in the neutral position.MethodsThirty sets of computed tomography images of the elbow were acquired, and a three‐dimensional model of the proximal radius and ulna was generated. The radius of curvature of the radial head and the radial head at the maximal pronation, neutral positions and maximal supination were calculated and compared with a one‐way analysis of variance.ResultsThe point on the radial head contacting the middle point of radial head at the maximal pronation and supination was located at the ends of the semi‐major axis of the ellipse, while it was located at one end of the semi‐minor axis at neutral position. The radii of curvature of the pronation, neutral and supination points of the radial head were 14.72 ± 1.51, 9.74 ± 1.49 and 14.58 ± 1.70 mm, respectively. The value of the neutral point was significantly smaller than that of the pronation and supination points.ConclusionsThis study quantitatively evaluated the morphology of the radial head and suggested that the best congruency of the PRUJ was achieved at maximal pronation and supination, while the neutral position was associated with the least congruency.Level of EvidenceBasic Science Study.
Effect of Acetic Acid on Biofilm Formation in Paracidovorax citrulli, Causal Agent of Bacterial Fruit Blotch
Authors: Yang Jincheng , Mao Liang , Gulfam Yousaf , Zeeshan Muhammad , Wang Xiaodong , Fan Ting 
Published: October 2024

ABSTRACTThe unique tissue structure of pathogenic bacteria biofilm plays an important role in its pathogenicity and bactericide resistance. Inhibition or destruction of biofilm formation of pathogenic bacteria is of great significance for the control of plant bacterial diseases. In this study, Paracidovorax citrulli was inoculated into KB medium containing acetic acid, and after shaking at 28°C and 55 r/min for 48 h, it was found that the content of extracellular polysaccharide, extracellular protein and extracellular DNA (eDNA) decreased with the increase of acetic acid concentration, which resulted in the decrease of biofilm formation, it is not even possible to form biofilms on plastic slides. When the final concentration of acetic acid in the culture medium was greater than or equal to 0.5 mg/mL, there was no biofilm on the plastic slides. Therefore, the use of acetic acid as an inhibitor of P. citrulli has a good potential for control of bacterial fruit blotch.
Compound Hot and Dry Events in Argentina and Their Connection to El Niño‐Southern Oscillation
Authors: Lopez‐Ramirez Agustina , Barrucand Mariana , Collazo Soledad 
Published: October 2024

ABSTRACTThis work studies the simultaneous and sequential occurrence of hot and dry months in the summer season in Argentina, north of 40°S, based on three different databases: meteorological stations, a gridded observational dataset and a reanalysis product. The influence of the El Niño‐Southern Oscillation (ENSO) over the occurrence of these compound events is specially analysed using a logistic regression model. Monthly maximum temperature and precipitation data are used for the period 1979–2022 in four sub‐regions of Argentina: Northwestern Argentina (NOA), Northeastern Argentina (NEA), Cuyo (central‐western Argentina) and the Pampas (central‐eastern Argentina). Simultaneous hot and dry months and hot months preceded by dry months are the most frequent compound events. The highest frequencies are found in the centre part of the study region and NEA for simultaneous compound events, and in NOA and the Pampas region for sequential ones. In general terms, all datasets show a good representation of the spatio‐temporal variability of hot and dry months. The insights of the influence of ENSO on compound events revealed that La Niña enhances the occurrences of hot and dry months throughout the study region, with the exception of NOA, where El Niño conditions promote the occurrence of these events. Based on logistic regression models, we successfully quantify the relationship between ENSO and hot and dry months and demonstrate that ENSO plays a significant role as a driver of compound hot and dry events in the central region, Cuyo, NEA and a portion of the Pampas. This research contributes to the understanding of compound events in Argentina and how they are influenced by major drivers of climate variability providing useful information for the development of a predictive system for such events.