bluuebunny/crossref_metadata_2025_split huggingface dataset:
Special considerations for hidradenitis suppurativa in skin of colour: A review of literature
Authors: Prieto Kaley , Lovell Katie K. , Feldman Steven R. , Pichardo Rita O. 
Published: October 2024

AbstractHidradenitis suppurativa, a chronic inflammatory skin condition, disproportionately affects individuals with skin of colour (SOC), particularly African Americans. Despite the increased prevalence in SOC, racial minorities are underrepresented in HS clinical trials, limiting our understanding of treatment efficacy. The purpose of this narrative review is to discuss the current literature regarding the clinical presentation, comorbidities, and management of HS in SOC individuals. A PubMed search was conducted using the terms Hidradenitis suppurativa, comorbidities, skin of colour, African–American, Hispanic, and quality of life with relevant studies written in English and pertaining to the demographics and clinical trials were included. African American patients with HS tend to experience more severe disease manifestations, higher rates of comorbidities like inflammatory bowel disease and anaemia, increased healthcare utilisation, and a greater likelihood of surgical interventions. While the current literature provides extensive information about African Americans regarding comorbidities and disease prevalence, there is a lack of research on Hispanic and other ethnic groups. For future research, it is important to broaden our focus to include various ethnic groups. Addressing these disparities requires focused interventions, inclusive clinical research initiatives, and healthcare policies tailored to the specific needs of patients with skin of colour.
Singing Voice Handicap Index‐10 Minimal Clinically Important Difference: A Prospective Determination
Authors: Perrin Claire E. , Young VyVy N. , Ma Yue , Rosen Clark A. , Stockton Steven D. , Schneider Sarah L. 
Published: October 2024

Background/ObjectivesThe Singing Voice Handicap Index‐10 (SVHI‐10) is a validated patient‐reported outcome measure (PROM) that assesses patients' perception of handicap related to singing voice. A normative value has been established with a score ≥20 being abnormal. However, there is no defined minimal clinically important difference (MCID). This study prospectively determines the MCID of SVHI‐10 among a diverse group of singers.Methods103 adult singers with and without voice complaints completed SVHI‐10 twice, 30 days apart. MCID for the SVHI‐10 was determined using distribution‐based receiver‐operating characteristic (ROC) curve analysis.ResultsTwenty‐two men (1 transgender), 75 women (1 transgender), and 6 nonbinary individuals participated. The most frequently reported singing genres were classical (44.7%), musical theater (17.5%), and pop (10.7%). Mean initial SVHI‐10 score was 13.05 (standard deviation 7.397), and mean follow‐up SVHI‐10 was 13.13 (7.994). There was a significant positive correlation between initial and follow‐up SVHI‐10 scores (r = 0.879, p < 0.001). SVHI‐10 scores were significantly higher among participants who reported voice changes in the past year (p < 0.001) or sought voice treatment (p = 0.001) compared with participants who did not. SVHI‐10 scores varied significantly based on singing type. The area under the ROC curve for SVHI‐10 was 0.700 (p = 0.003). The SVHI‐10 MCID was determined to be 9.5.ConclusionsAn SVHI‐10 score change ≥10 should be considered clinically meaningful. This definition has been missing from the literature and will improve understanding of patients' responses to treatment, which will help advance clinical care and track research outcomes.Level of Evidence4 Laryngoscope, 135:752–757, 2025
An Exceptionally Salt Tolerant Copoly(Maleimide Sulfobetaine) – Structural Requirements for Ultra‐Salt Tolerance
Authors: Aitipamula Srinivasulu , Hadia Nanji J. , Vasantha Vivek A. , Parthiban Anbanandam 
Published: October 2024

AbstractZwitterionic polymers are an important class of polymers with far‐ranging applications. In the widely studied poly(meth)acrylate and poly(meth) acrylamide‐based zwitterions, properties can be tuned by changing the nature of substituents attached to ammonium ions. However, these changes influenced salt tolerance of zwitterionic polymers only to a limited extent. Upon adding salt these polymers expanded in solution initially. Further increase in salt concentration caused the polymer chains to shrink similar to the common water soluble, uncharged polymers thereby deteriorating the viscosity of aqueous solutions. In contrast to the conventional poly(meth)acrylate and poly(meth)acrylamide‐based zwitterions, zwitterionic copolymaleimides showed substituent dependent salt‐tolerant nature. In the absence of any substituent on the polymer backbone such as zwitterionic poly(ethylene‐alt‐maleimide) (ZI‐PEMA) the viscosity of salt solutions increased both with the increasing salt concentration as well as the concentration of polymer. This is likely due to the continuous expansion of polymer coil in salt solutions with increasing salt concentration caused primarily by the rigidity of the polymer backbone. ZI‐PEMA also enhanced the saturation limit of mono‐ and divalent salts like sodium chloride and hydrated calcium bromide in water. This property is useful for various applications like fish curing, for making high‐density fluids, refrigeration, etc. across various industrial sectors.
Use of FISH‐FLOW as a Method for the Identification and Quantification of Bacterial Populations
Authors: Vazquez Bucheli Jorge Enrique , Lee Yuri , Kim Bobae , Azevedo Nuno F. , Azevedo Andreia S. , Todorov Svetoslav Dimitrov , Ji Yosep , Kang Hyeji , Holzapfel Wilhelm H. 
Published: October 2024

AbstractThe gastrointestinal tract (GIT) harbors the largest group of microbiotas among the microbial communities of the human host. The resident organisms typical of a healthy gut are well adapted to the gastrointestinal environment while alteration of these populations can trigger disorders that may affect the health and well‐being of the host. Various investigations have applied different tools to study bacterial communities in the gut and their correlation with gastrointestinal disorders such as inflammatory bowel disease (IBD), obesity, and diabetes. This study proposes fluorescent in situ hybridization, combined with flow cytometry (FISH‐FLOW), as an alternative approach for phylum level identification of Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria and quantification of target bacteria from the GIT based on analysis of fecal samples, where results are validated by quantitative polymerase chain reaction (qPCR) and 16S ribosomal ribonucleic acid (16s rRNA) sequencing. The results obtained via FISH‐FLOW experimental approach show high specificity for the developed probes for hybridization with the target bacteria. The study, therefore, suggests the FISH‐FLOW as a reliable method for studying bacterial communities in the gut with results correlating well with those of metagenomic investigations of the same fecal samples.
Microscopic Thermo‐Mechanical Properties and Phase Transition of Bulk Ice‐Ih
Authors: Wei Pengchang , Niu Weiwei , Yao Chi , He Zhenyu , Zheng Yuan‐Yuan , Ma Wei 
Published: October 2024

ABSTRACTThe ice–water phase transition of bulk ice could develop with varying temperatures and external loads, significantly affecting its mechanical properties. The coupling effect of temperature and shear loads on the thermo‐mechanical properties of bulk ice and its phase transition evolution is poorly understood, especially at the nanoscale. In this study, molecular dynamics (MD) simulation method was employed to investigate the thermo‐mechanical behaviours of bulk ice‐Ih system at the microscale under various temperatures (73–270 K) and shear paths, where its phase transition, elastic properties, structure deformation mechanism and structural anisotropy were discussed. The simulation results show that (1) the shear modulus, shear strength and ultimate shear strain of bulk ice‐Ih system could linearly decrease with rising temperature, aligning with previous studies. (2) Two types of failure modes from bulk ice‐Ih system were founded, such as solid–liquid phase co‐existence at 73–225 K and liquid phase at 250–270 K. (3) Ice melting into water was attributed to the fracture of hydrogen bond during shear process. (4) Compared to vertical shearing (XZ () and YZ ()) directions, the mechanical response along the horizontal shearing (XY (0001)) direction was most sensitive to temperature effect.
A general label setting algorithm and tractability analysis for the multiobjective temporal shortest path problem
Authors: Bazgan Cristina , Kager Johannes , Thielen Clemens , Vanderpooten Daniel 
Published: October 2024

AbstractGiven a directed temporal graph, a start node , and objectives, the task in the single‐source multiobjective temporal shortest path problem (SSMTSPP) consists of computing the set of nondominated images of temporal ‐‐paths for each node as well as one corresponding efficient path for each of these images. This problem generalizes both the multiobjective shortest path problem in static graphs and the single‐objective temporal shortest path problem. In this article, we provide a general label setting algorithm for the SSMTSPP that can handle a large variety of different objectives. The only condition imposed on the objectives is a monotonicity property that generalizes the nonnegativity of the arc costs required for the well‐known label setting algorithm for solving the static single‐source shortest path problem in both the single objective and the multiobjective case. Our analysis of the presented algorithm shows that its worst‐case running time is polynomial in the sum of the input size of the problem instance and the number of nondominated images, which implies that it runs in polynomial time as long as the number of nondominated images is polynomial in the instance size (i.e., for all tractable versions of the problem). To complement this result, we provide a complete classification into tractable and intractable problems for all SSMTSPPs involving a large variety of objectives. In particular, using our general analysis, this provides a large range of specific SSMTSPPs for which our general label setting algorithm runs in polynomial time.
From the wetlands to the farmyard: Osteometric approach to the presence of domestic geese and ducks in Zuid Holland, 150–1700 AD
Authors: de Segovia de Kraker Noé , Llorente‐Rodríguez Laura 
Published: October 2024

AbstractThe history of domestic ducks (Anas platyrhynchos domesticus) and domestic greylag geese (Anser anser domesticus) remains poorly understood. This is mainly caused by the difficulty of identifying archaeological bones as domestic due to the existing overlap in sizes. A recently published osteometrical methodology is applied that successfully allows to identify domestic forms and distinguish between anatid species with more confidence. Four archaeological assemblages from the Zuid Holland province in the Netherlands are reanalyzed, ranging from the Roman period to the 17th century AD.It is determined that domestic geese were present in the Netherlands since at least 160–230 AD and domestic ducks since at least 585–725 AD. The latter might also be present in the Roman assemblage, but the evidence is inconclusive. Domestic species constitute only a small percentage of the total consumed anatids and do not surpass 15%–20% in any case, which is mainly caused by the weight of wildfowling in the Netherlands. Chickens (Gallus gallus domesticus) were therefore much more prevalent than domestic anatids in all assemblages. Taphonomical analysis did not show substantial differences between wild and domestic anatids. The sample size considered in this project is likely too small and biased to accurately detect any kind of evolution through time.
Aristolochic acid‐related renal cell carcinoma exhibits a distinct tumor‐immune microenvironment favoring response to immune checkpoint blockade
Authors: Lin Po‐Hung , Chan Jason Yongsheng , Guan Peiyong , Hong Jing Han , Lim Abner Herbert , Ng Cedric Chuan‐Young , Yeong Joe Poh Sheng , Lee Jing Yi , Liu Wei , Lim Jeffrey Chun Tatt , Pang See‐Tong , Teh Bin Tean 
Published: October 2024

AbstractImmune checkpoint blockade (ICB) is currently the standard of care for metastatic renal cell carcinoma (RCC), but treatment responses remain unpredictable. Aristolochic acid (AA), a prevalent supplement additive in Taiwan, has been associated with RCC and induces signature mutations, although its effect on the tumor‐immune microenvironment (TIME) is unclear. We aimed to investigate the immune profile of AA‐positive RCCs and explore its potential role as a susceptible candidate for ICB. Tissue samples from 22 patients with clear cell RCC (ccRCC) were collected for whole‐exome sequencing to determine the genetic features and AA mutational signature (the discovery cohort). The corresponding RNA was sent for NanoString PanCancer IO 360 gene expression analysis to explore the immunological features. The formalin‐fixed, parafilm‐embedded slides of ccRCCs were sent for multiplex immunohistochemistry/immunofluorescence stain using Vectra system to evaluate the TIME. Tissues from two patients with metastatic RCC demonstrating complete response to ICB were sent for studies to validate the findings (the index patients). The results showed that AA mutational signatures with high tumor mutational burden (TMB) were present in 31.81% of the tumors in the discovery cohort. Three distinct clusters were observed through NanoString analysis. Clusters 1 and 3 were composed mainly of AA‐positive RCCs. Cluster 3 RCCs exhibited higher tumor inflammation signature scores and higher immune cell type scores. Vectra analysis revealed a higher percentage of CD15+ and BATF3+ cells in cluster 1, whereas the percentage of CD8+ cells was potentially higher in cluster 3. Strong AA mutational signatures were found in the tumors of two index patients, and both were grouped to cluster 3. In conclusion, AA may induce higher TMB and alter the immune microenvironment in RCCs, which makes the tumors more susceptible to ICB. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Concomitant use of dextromethorphan and alcohol‐induced dissociation in a patient with alcohol dependence
Authors: Nagai Yasuhito , Tajima Yuko , Miyakawa Koichi 
Published: October 2024

AbstractBackgroundDextromethorphan (DXM) is an over‐the‐counter drug that is commonly abused by teenagers. Its main pharmacological property is a low‐affinity N‐methyl‐d‐aspartate (NMDA) receptor antagonist.Case PresentationWe report acute psychotic dissociation induced by DXM and alcohol in a patient with alcohol dependence, which made it difficult to distinguish alcohol withdrawal symptoms with limited information. The psychotic symptoms were ameliorated by haloperidol; however, in cases of DXM abuse, haloperidol treatment should be avoided.ConclusionIn the consultation of patients with addiction, the possibility of various addictive drugs must be kept in mind. The concomitant use of DXM and alcohol causes easy dissociation and high‐dose usage of DXM and alcohol withdrawal symptoms are difficult to distinguish.
Hear, act, connect, support: Youth recommendations for educators who administer school climate surveys
Authors: Duane Addison , Morris Kamryn S. , Nash Amia , Jones Tiffany M. , Shapiro Valerie B. 
Published: October 2024

AbstractSchool climate surveys are commonly used to solicit youth perspectives about their experiences in schools. However, to move climate surveys from solicitation towards a more youth‐centered, partnered practice for school improvement, guidance is needed from the youth themselves about how and in what ways they hope adults respond to their survey responses. In the present study, we analyzed data from four focus groups conducted with middle school and high school students. Findings reveal that, following the administration of climate surveys, youth want adults to: recognize their voices, take action based on their responses, cultivate opportunities for connection, and increase mental health supports. These student‐generated insights can help inform how adults in schools—from educational leaders to licensed mental health professionals—use student data to inform decision‐making.
Greenhouse Gas Production and Microbial Response During the Transition From Terrestrial Permafrost to a Marine Environment
Authors: Jenrich Maren , Angelopoulos Michael , Liebner Susanne , Treat Claire , Knoblauch Christian , Yang Sizhong , Grosse Guido , Giebeler Fiona , Jongejans Loeka L. , Grigoriev Mikhail , Strauss Jens 
Published: October 2024

ABSTRACTArctic permafrost coasts, affected by rising sea levels and increasing coastal erosion in a warming climate, undergo significant changes. Simulating how permafrost is impacted by inundation with fresh, brackish and marine water enhances our understanding of permafrost carbon stock responses to increasingly marine conditions. We investigated CO2 and CH4 production during key transitions in a coastal thermokarst landscape on the Bykovsky Peninsula, Siberia, assessing short‐ and long‐term microbial responses to varying salinities in anaerobic 1‐year incubation experiments. Initially, CO2 production from saltwater‐inundated permafrost was low due to the low abundance of salt‐tolerant microbial communities. Over the long term, after simulated lagoon formation and the growth of sulfate‐reducing bacteria, CO2 production surpassed that of the terrestrial sites by 8 times. CO2 and CH4 production was lowest under fully marine conditions, suggesting incomplete adaptation of microbes. Rapid ecosystem changes stress microbial communities, with greenhouse gas production highest under near‐natural conditions. With an increase in lake drainage events and rising sea levels, thermokarst lagoon distribution on Arctic coasts will escalate, resulting in a further increase of carbon mineralization and CO2 release. With this study, we provide first estimations on greenhouse gas production during the transition from terrestrial to submarine conditions in permafrost‐affected aquatic systems.
The bidirectional interplay of obstructive sleep apnea and viral respiratory infections in children: A novel opportunity for primary prevention
Authors: Nino Gustavo , Chorvinsky Elizabeth , Bhattacharya Surajit , Gutierrez Maria J. 
Published: October 2024

AbstractObstructive sleep apnea (OSA) and viral respiratory infections are highly prevalent conditions in children and a major cause of respiratory morbidity in this age group. Severe viral respiratory infections are a known risk factor for pediatric OSA, which is primarily caused by hypertrophy of upper airway lymphoid tissues (adenoids and tonsils). This review examines recent progress in understanding early‐life development of lymphoid tissues in the human upper airway, with a particular focus on how respiratory viruses may influence this process and contribute to OSA pathogenesis. It also explores the bidirectional relationship between OSA and severe viral infections, highlighting the need for ongoing monitoring and novel primary prevention strategies to address these interconnected conditions.
Identification and field verification of the aggregation pheromone components produced by male Holotrichia parallelaMotschulsky (Coleoptera: Scarabaeidae)
Authors: Qu Ya‐Fei , Li Xue , Dong Huan‐Huan , Wang Wen‐Jie , Li Xiao‐Feng , Feng Honglin , Zhang Shuai , Cao Yazhong , Yin Jiao , Li Kebin 
Published: October 2024

AbstractBACKGROUNDThe chafer beetle, Holotrichia parallela, causes damage to numerous economically significant crops worldwide. Adult beetles exhibit aggregation behavior likely mediated by a male‐produced pheromone. Advancements in biological research technology have facilitated the identification of insect aggregation pheromones and promoted their applications as bait for trapping and monitoring pests. Currently, only a few active components of aggregation pheromones from Holotrichia species have been identified. However, the specific components of aggregation pheromones produced by H. parallela remain unknown.RESULTIn this study, we initially observed from Y‐tube olfactometer assays that both male and female H. parallela were significantly attracted to volatiles emitted by males, but not to those from females. We then collected hindgut crude extracts of male adults and carried out gas chromatography–mass spectrometry analysis to identify potential aggregation pheromone components. Pentadecyl acetate, cis‐13‐docosenol, and behenic acid were identified as male‐specific compounds in comparison to female extracts, serving as components of the aggregation pheromone in H. parallela. We further evaluated their attractiveness to H. parallea in both laboratory and field experiments. In laboratory settings, pentadecyl acetate, cis‐13‐docosenol, and behenic acid evoked significant responses to both males and females at specific concentrations, as evidenced by both electroantennography tests and behavioral bioassays. Under field conditions, traps baited with these three compounds captured significantly more H. parallela adults compared to control traps.CONCLUSIONIn this study, we found that pentadecyl acetate, cis‐13‐docosenol, and behenic acid are specifically present in male H. parallela, serving as aggregation pheromones. Both laboratory and field‐trapping experiments suggest their potential as monitoring and controlling tools against H. parallela adults. © 2024 Society of Chemical Industry.
COPD associated pulmonary hypertension: A post hoc analysis of the PERFECT study
Authors: Nathan Steven D. , Lacasse Victoria , Bell Heidi , Sista Prakash , Di Marino Michael , Bull Todd , Tapson Victor , Waxman Aaron 
Published: October 2024

AbstractThe PERFECT study, a randomized, controlled, double‐blind study of inhaled treprostinil in patients with COPD and associated pulmonary hypertension (PH‐COPD) was a negative trial that was terminated early. The reason(s) for the negative outcome remains uncertain. A post hoc analysis of data from the PERFECT study was undertaken to identify adverse responders and possibly potential responders. The goal was also to provide insight into phenotypes for possible inclusion and exclusion in future PH‐COPD clinical trials. An adverse response on active treatment was seen in 36.4% (24/66) of the subjects compared to 27.6% (16/58) on placebo. There was no evidence to suggest that hyperinflation, bronchospasm, or occult heart failure played any role in the untoward outcomes of the study. The patients who died during the study all had baseline diffusing capacity for carbon monoxide ≤25% of predicted. Evidence of a potential response was seen in 10.6% (7/66) of the patients who received inhaled treprostinil. Patients who had evidence of a treatment response had a baseline mean pulmonary artery pressure of ≥40 mmHg and a forced expiratory volume in the first second of ≥40%. Change in N‐terminal prohormone of brain natriuretic peptide did not predict clinical response. This post hoc analysis provides information that may potentially enable improved selection of patients for future therapeutic trials in PH‐COPD. These analyses are post hoc, observational, and exploratory. The thresholds defining the spectrum of responders are preliminary and may require further refinement and validation in future studies.