bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 3429: Evidence chronic inflammation is a risk factor for histiocytic sarcoma in Bernese mountain dogs - implications for human histiocytic sarcoma
Authors: Ruple-Czerniak Audrey , Morley Paul S. 
Published: July 2016

Abstract
The purpose of this study was to evaluate exposure variables associated with development of histiocytic sarcoma (HS), a rare but aggressive malignancy, using the canine spontaneous tumor model. The domestic dog has been shown to be an excellent model to investigate risk of occurrence of complex diseases in humans, especially cancers. This is due in part to the limited genetic heterogeneity within specific dog breeds. HS, though rare in most breeds of dogs, is a common malignancy in Bernese mountain dogs (BMD) with up to 25% of the population of dogs being diagnosed with HS during their lifetime. The frequency of HS diagnosis in BMDs is thought to be due to a heritable mutation in a single gene region analogous to the human chromosome 9p21. For this study, owners of BMDs registered with a non-profit breed registry, the Berner-Garde Foundation, were recruited for participation in an internet-based cross-sectional survey. Data were collected for a total of 216 BMDs. Of the total population of BMDs enrolled in the study 118 dogs were sibling-sets representing a case and a non-case that originated from the same litter. Mixed effects logistic regression (MELR) and conditional logistic regression (CLR) were used in parallel to examine associations between potential risk factors and the occurrence of HS. When controlling for litter of origin (as a marker of relatedness), dogs diagnosed with orthopedic conditions were found to be more likely to develop HS (MELR, OR: 2.5, 95% CI: 1.5, 5.2; CLR, OR: 2.81, 95% CI: 1.1, 7.3), while dogs receiving prescription anti-inflammatory medications were found to be at a considerably lower risk of developing this disease (MELR, OR: 0.43, 95% CI: 0.2, 0.8; CLR, OR: 0.32, 95% CI: 0.1, 0.8). These data suggest inflammation may be a modifiable risk factor for the development of HS. Therefore, identification and treatment of conditions that promote inflammatory mechanisms may reduce future risk of developing HS in dogs and people. Results of logistic regression models examining risk factors associated with development of histiocyRisk factorCategoryOdds ratio (MELR), n = 21695% CIP-ValueOdds ratio (CLR), n = 11895% CIP-ValueOrthopedic conditionYes2.491.21, 5.140.0142.811.08, 7.260.034NoReferenceReferenceNon-prescription medication useYes2.101.05, 4.180.0362.881.04, 7.900.041NoReferenceReferenceLong-term prescription medication useYes0.430.22, 0.810.0100.320.12, 0.830.020NoReferenceReference
Citation Format: Audrey Ruple-Czerniak, Paul S. Morley. Evidence chronic inflammation is a risk factor for histiocytic sarcoma in Bernese mountain dogs - implications for human histiocytic sarcoma. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3429.
Abstract 3433: Association between serum concentrations of polychlorinated biphenyls (PCBs) and increased risk of breast cancer among US women
Authors: Morgan Marisa , Deoraj Alok , Roy Deodutta 
Published: July 2016

Abstract
The main objective of this study was to examine the cross-sectional relationship between exposure to PCBs or their congeners and breast cancer among US women. There is limited information on the association of specific PCB congener or their combination levels in blood serum with increased breast cancer risk. PCBs are weak estrogens which has been shown to act as endocrine disrupters by increasing or blocking estrogen like activities in animals and humans. We analyzed National Health and Nutrition Examination Survey (NHANES) data from 1999-2004 in the lipid adjusted blood samples of female participants (&gt;20 years of age). Exposure assessment was based on lipid adjusted serum levels of 6 individual PCB congeners (PCB 074, 099, 118, 138, 153, and 180), the sum of dioxin-like PCBs (074 and 118), and the sum of non-dioxin-like PCBs (099 + 138 + 153+187) in conjunction with data obtained from the medical and reproductive health questionnaires. We calculated geometric means to compare PCB concentrations in women's blood samples who also self-reported a breast cancer diagnosis and women who were never diagnosed with cancer. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI) for the association between PCB, their congener or their combinations and breast cancer. We evaluated age, race/ethnicity, age at menarche, body mass index (BMI; kg/m2), and lactation as potential confounders. Our results show a weighted geometric mean levels of 6 PCB congeners to be significantly higher in blood serum among women with breast cancer when compared to the rest of the study population. After adjusting for age, race, BMI, lactation, and age at menarche we found significant association of PCB 138 with breast cancer [odds ratios of 2.88; 95% confidence interval (CI): 1.14-7.30; 2.93, 95% CI: 1.04-8.26; and 3.43, 95% CI: 1.12-10.4] in women with higher body burdens of individual PCB congeners (&gt; 50th percentile, 50th-75th percentile, and ≥75th percentile), respectively. After adjusting for age and race, it was also found that the sum of non-dioxin-like PCBs (074 and 118) in blood serum is significantly associated with breast cancer [OR of 1.14; 95% CI: 1.00-1.29]. In summary, our results suggest a possible link between environmental exposures to PCBs and increased risk of breast cancer among U.S. women.
Citation Format: Marisa Morgan, Alok Deoraj, Deodutta Roy. Association between serum concentrations of polychlorinated biphenyls (PCBs) and increased risk of breast cancer among US women. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3433.
Abstract 3444: Analysis of human papillomavirus 16 variants and risk for cervical cancer in Chinese population
Authors: Hang Dong , Yin Yin , Han Jing , Jiang Jie , Ma Hongxia , Xie Shuanghua , Feng Xiaoshuang , Zhang Kai , Hu Zhibin , Hongbing Shen , Clifford Gary M. , Dai Min , Li Ni 
Published: July 2016

Abstract
HPV16 is the most carcinogenic HPV type, but only a minority of HPV16 infections progress to cancer. Intratype genetic variants of HPV16 have been suggested to confer differential carcinogenicity. To investigate risk implications of HPV16 variants among Chinese women, a case-control study was conducted with 298 cervical cancer patients and 85 controls (all HPV16-positive). HPV16 isolates were predominantly of the A variant lineage, and variants of A4 (previously named “Asian”) sublineage were common. A4/Asian variants were significantly associated with increased risk of cervical cancer compared to A1-3 (OR = 1.72, 95% CI = 1.04-2.85). Furthermore, a meta-analysis including 703 cases and 323 controls from East Asia confirmed the association (OR = 2.82, 95% CI = 1.44-5.52). In conclusion, A4 variants appear to predict higher risk of cervical cancer among HPV16-positive women, which may provide clues to the genetic basis of differences in the carcinogenicity of HPV16 variants.
Citation Format: Dong Hang, Yin Yin, Jing Han, Jie Jiang, Hongxia Ma, Shuanghua Xie, Xiaoshuang Feng, Kai Zhang, Zhibin Hu, Shen Hongbing, Gary M. Clifford, Min Dai, Ni Li. Analysis of human papillomavirus 16 variants and risk for cervical cancer in Chinese population. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3444.
Abstract 3449: Placental characteristics and risk of cryptorchidism among populations at high and low risk of testicular germ cell tumors
Authors: Ghazarian Armen A. , Trabert Britton , Graubard Barry , Longnecker Matthew , Klebanoff Mark , McGlynn Katherine 
Published: July 2016

Abstract
Background: Testicular germ cell tumors, which are significantly more common among white men than black men in the U.S., are thought to be part of a Testicular Dysgenesis Syndrome (TDS) that also includes impaired fertility, hypospadias and cryptorchidism. The etiology of the TDS conditions is not well understood, but the in-utero milieu is likely to be a significant factor. As the placenta is a critically important determinant of the in-utero milieu, placental characteristics may play a role in determining risk of the TDS conditions. Prior evidence suggests that placental weight, in particular, may be associated with cryptorchidism.
Methods: We examined placental characteristics (weight, thickness, placental weight/birth weight ratio, infarct size, disorders of membrane development, presence of macrophages in the amniotic fluid) and cryptorchidism in a nested case-control study within the Collaborative Perinatal Project (CPP). The CPP was a maternal-child cohort study conducted in 12 medical centers in the U.S. between 1959 and 1965. Diagnoses of cryptorchidism made during the first year of life were included in the case group. The analysis contrasted 413 (232 white, 181 black) boys with cryptorchidism to 23,799 (12,092 white, 11,707 black) boys without cryptorchidism. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression, stratified by race.
Results: Among white boys, cryptorchidism was significantly associated with circummarginate placenta (OR: 1.7, 95% CI: 1.1-2.7) or a combination of circummarginate/circumvallate (OR: 1.3, 95% CI: 1.0-1.8) placenta. Among black boys, cryptorchidism was significantly associated with having at least one placental infarct greater than 3 cm (OR: 2.3, 95% CI: 1.1-4.8) and with placental weight in the lower (OR: 1.7, 95% CI: 1.1-2.6) or higher (OR: 1.5, 95% CI: 1.0-2.3) tertile compared with the middle tertile. No significant associations were found between cryptorchidism and the other placental characteristics in either white or black boys.
Conclusion: These results suggest that there may be associations between cryptorchidism and certain placental characteristics which differ between white and black births. The race-specific findings suggest an area where future research may prove fruitful.
Citation Format: Armen A. Ghazarian, Britton Trabert, Barry Graubard, Matthew Longnecker, Mark Klebanoff, Katherine McGlynn. Placental characteristics and risk of cryptorchidism among populations at high and low risk of testicular germ cell tumors. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3449.
Abstract 345: Olive oil-based oleocanthal and bioisosteres as c-Met inhibitors for the control of triple negative breast cancer
Authors: Ebrahim Hassan Y. , Mohyeldin Mohamed M. , Siddique Abu Bakar , Akl Mohamed R. , Ibrahim Mostafa , El Sayed Khalid A. 
Published: July 2016

Abstract
Breast cancer is the most commonly diagnosed cancer in women, claiming the lives of hundreds of thousands of women each year. Dysregulation of c Met correlates with aggressive proliferation, invasive character, and pathological motility, especially in triple negative breast cancer (TNBC). The Mediterranean diet is known to reduce the incidence of breast and colon malignancies. Extra-virgin olive oil (EVOO) represents a main ingredient in this diet. The EVOO-derived (-)-oleocanthal was shown to target the RTK c-Met. Oleocanthal selectively inhibited the proliferation, migration and invasion of several c-Met dependent breast and prostate tumor cell lines. Oleocanthal exerted potent in-vivo efficacy in an orthotopic athymic nude mouse breast cancer xenograft model much greater than its modest in-vitro potency. Several oleocanthal bioisosteres have been semisynthized of which the analog HVS have shown significant activity improvement against breast cancer in vitro and in vivo models. Selectivity profiling against a TKs panel, structurally related to c-Met, suggested the HVS has high selectivity to both Met and ABL1 kinases. Overexpression of ABL1 kinase is implicated in the progression of several solid tumors concomitantly with c-Met activation, including breast, colon, lung and other cancers. ABL1 interconnects oncogenic Met and p53 pathways and hence dual blockage of c-Met and ABL1 activation adds significant advantages over currently approved c-Met inhibitors and may justify its potent in vitro and in vivo activities. Therefore, the dual c-Met/ABL1 inhibitor HVS could not only be effective in slowing TNBC progression but also could prevent drug resistance. Detailed molecular and cellular mechanistic studies of oleocanthal and its bioisosteres indicate their potential for future use to control TNBC and other c-Met-dependent malignancies. This study was supported by NIH/NCI project 1R15CA167475-01.
Citation Format: Hassan Y. Ebrahim, Mohamed M. Mohyeldin, Abu Bakar Siddique, Mohamed R. Akl, Mostafa Ibrahim, Khalid A. El Sayed. Olive oil-based oleocanthal and bioisosteres as c-Met inhibitors for the control of triple negative breast cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 345.
Abstract 3450: Epidemiological factors associated with breast cancer in young women
Authors: Toro Allyson L. , Hueman Matthew T. , Shriver Craig D. , Ellsworth Rachel E. 
Published: July 2016

Abstract
Background: Although breast cancer in young women (YW, &lt;40 years) only accounts for ∼7% of cases diagnosed annually, tumors in young patients have more aggressive characteristics and higher mortality rates. The cost of breast cancer increases significantly with more aggressive tumors in terms of treatment costs, physical and psychosocial effects on the patient and her family, and lost productivity. Improved understanding of factors associated with etiology of breast cancer in YW is critical to developing more effective prevention strategies and improved treatments, reducing the burden of breast cancer in this population.
Methods: The Clinical Breast Care Project database was queried to identify all YW with invasive breast cancer or benign breast conditions diagnosed after surgical evaluation between 2001 and 2014 that had questionnaire data available from the time of diagnosis. Epidemiological factors including reproductive and health history and lifestyle choices were using Student's t-tests and chi-square analysis with P&lt;0.05 defining significance.
Results: Neither ethnicity nor family history differed significantly between YW with and without breast cancer. Reproductive factors that differed significantly between groups include longer use of oral contraceptives (P&lt;0.001, 93 compared to 66 months), older age at first full-term pregnancy (FFTP, P = 0.002, 24.5 compared to 22.7 years), and longer duration of breastfeeding in parous YW (P = 0.024, 15.1 compared to 10.4 months) in YW with invasive breast cancer compared to those with benign conditions. YW with invasive breast cancer were also significantly more likely to be married (P = 0.043, 78% compared to 68%) and less likely to exercise (P = 0.003, 31% compared to 17%) compared to those with benign breasts.
Conclusions: Of the factors evaluated, including reproductive history, lifestyle choices, and co-morbidities, only five differed significantly between YW with and without invasive breast cancer. Paradoxically, breastfeeding, which has been associated with reduced the risk of breast cancer, was higher in YW who developed invasive breast cancer. In contrast, parity and use of oral contraceptives are associated with transient increases in breast cancer risk. The older age at FFTP of YW with invasive breast cancer combined with the significantly longer exposures to oral contraceptives may create an environment within the breast favorable to tumor initiation and progression.
Citation Format: Allyson L. Toro, Matthew T. Hueman, Craig D. Shriver, Rachel E. Ellsworth. Epidemiological factors associated with breast cancer in young women. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3450.
Abstract 3456: Polychlorinated biphenyls and relative telomere length in the Anniston Community Health Survey: A cross-sectional study
Authors: Callahan Catherine , Pavuk Marian , Ren Xuefeng , Olson James R. , Bonner Matthew R. 
Published: July 2016

Abstract
Background: Polychlorinated biphenyls (PCBs) exposure is associated with increased risk of melanoma and non-Hodgkin lymphoma in some, but not all, epidemiologic studies. Although the carcinogenic mechanisms of specific PCB congeners remain to be fully explained, PCBs have been demonstrated to induce oxidative stress and inflammation and therefore may have deleterious impacts on telomere length. We investigated the association between serum concentrations of PCBs and telomere length in a highly exposed population.
Methods: The Anniston Community Health Survey (ACHS) is a cross-sectional study of 766 residents of Anniston, Alabama conducted between 2005 and 2007. We measured relative telomere length (RTL) with telomere/single copy gene ratio, in DNA extracted from peripheral blood samples in a subset of 57 African-American and 46 white participants, using monochrome multiplex quantitative polymerase chain reaction. We used multiple linear regression to estimate the association between 27 individual PCB congeners, and sum PCBs, adjusting for age, plate, and total lipids. All analyses were stratified by race. PCBs and RTL were log-transformed.
Results: ACHS participants had high serum concentrations of PCBs (mean sum PCBs among African-Americans = 14,687.69 ppt whole weight, SD = 23,515.46; mean sum PCBs white participants 6,088.32 ppt whole weight, SD = 8,750.57). RTL did not differ by race (mean RTL African-Americans = 0.94 SD = 0.08; mean RTL whites = 0.94, SD = 0.09). Among African-American participants, sum serum PCBs was not associated with RTL (0.70% per 100 ppt; 95% confidence interval = -9.43, 19.70). However, PCB 167 was weakly associated with higher RTL (2.35%, 95%CI = -8.56, 14.55), while PCB 157 was associated with shorter RTL (-4.36%; 95%CI = -15.63, 8.40). Among white participants, a 100 ppt increase in sum serum PCBs was associated with a 10.20% increase in RTL (95% CI = -7.10, 30.72). PCB 138, in particular, was associated with increased RTL among white participants (16.29%; 95% CI = 1.34, 33.46). Conversely, PCB 189 was associated with shorter RTL among white participants (-10.48%; 95%CI = -29.82, 14.19).
Conclusions: We did not observe consistent associations between serum concentrations of PCBs and RTL, suggesting that the association may vary by race and be congener specific. Our results are necessarily preliminary and are limited by the small number of participants. Additional measurements of RTL among ACHS participants are on-going.
Citation Format: Catherine Callahan, Marian Pavuk, Xuefeng Ren, James R. Olson, Matthew R. Bonner. Polychlorinated biphenyls and relative telomere length in the Anniston Community Health Survey: A cross-sectional study. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3456.
Abstract 3464: Low concordance with CEA tumor marker monitoring in colorectal cancer survivors
Authors: Palos Guadalupe , Gilmore Katherine R. , Chapman Patricia , Lewis-Patterson Paula , Bi Weiqi , Rodriguez Maria Alma 
Published: July 2016

Abstract
Purpose: To assess providers’ concordance with surveillance and risk reduction recommendations for colorectal cancer (CRC) survivors after completion of their curative treatment.
Patients and Methods:
This was a longitudinal study of survivors who met the following eligibility criteria: diagnosed with a primary colon or rectal cancer before their first visit (V) to the CRC Survivorship Clinic, adult survivor ≥ 18 years old, no evidence of disease, alive at the time of data abstraction, and 1-3 clinic visits between 9/01/2011 and 8/31/2014. Data were collected at V1 scheduled between 9/1/2011 and 8/31/2012. V2 was scheduled 9-15 months after the first visit. V3 was also scheduled 9-15 months after V2. Data sources were survivorship care plans, electronic medical records, and CRC survivorship algorithms. For an annual visit, CRC algorithms recommended history/physical exams (H & PEs), carcinoembryonic antigen (CEA) testing when previously elevated, and colonoscopies for surveillance of cancer recurrence. Concordance rates (CR) were measured as the percent of yes/no responses to whether the providers followed minimum standards for the 3 procedures. Demographic and clinical characteristics were also collected. Descriptive statistics were used to summarize all data.
Results:
81 of 117 CRC survivors who met all eligibility criteria were included in this sub-analysis. The number of survivors visits varied across time, V1 = 81, V2 = 56, and V3 = 36. Most survivors were male (51.9%) and Caucasian (66.7%). 67.9% reported being 5-8 years post-treatment. 58% were diagnosed with colon cancer and of those 61.7% were Stage IIIA-IV compared to 55.8% of rectal cancer survivors with advanced disease. Table 1 summarizes the percentage of CR rates across the 3 visits.
Conclusion:
CRs for H & PEs and colonoscopies remained high across the 3 visits. CRs were lowest for CEA recommendations. These low rates suggest further work is needed to determine barriers in clinical practice that limit use of CEA tumor marker monitoring in CRC survivors. Percent of Providers ConcordanceAlgorithm RecommendationVisit 1Visit 2Visit 3H & PE100100100CEA53.338.322.2Colonoscopy97.598.2100
Citation Format: Guadalupe Palos, Katherine R. Gilmore, Patricia Chapman, Paula Lewis-Patterson, Weiqi Bi, Maria Alma Rodriguez. Low concordance with CEA tumor marker monitoring in colorectal cancer survivors. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3464.