bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bimekizumab provided rapid improvements in patient-reported symptoms and health-related quality of life in patients with active psoriatic arthritis: pooled 16-week results from two phase 3 studies
Authors: Husni M Elaine , Mease Philip J , Merola Joseph F , Tillett William , Goldammer Nadine , Ink Barbara , Coarse Jason , Lambert Jérémy , Taieb Vanessa , Gladman Dafna D 
Published: September 2024

ObjectivesTo assess impact of bimekizumab treatment on patient-reported outcomes and health-related quality of life (HRQoL) in patients with active psoriatic arthritis (PsA), using 16-week data from two phase 3 studies.MethodsBE OPTIMAL (NCT03895203; biologic disease-modifying antirheumatic drug (bDMARD)-naïve) and BE COMPLETE (NCT03896581; tumour necrosis factor inhibitor inadequate response/intolerance (TNFi-IR)) are phase 3 studies of subcutaneous bimekizumab 160 mg Q4W; both were double-blind and placebo-controlled to 16 weeks. Patients were randomised 3:2:1 to bimekizumab, placebo or reference (subcutaneous adalimumab 40 mg Q2W) in BE OPTIMAL; 2:1 to bimekizumab or placebo in BE COMPLETE. Patient-reported outcomes for pain, fatigue, physical function and HRQoL are reported to week 16 using pooled and individual study data for bimekizumab and placebo patients.Results1073/1112 (96.5%) patients completed week 16 (bimekizumab:‍ 677/698 [97.0%]; placebo: 396/414 [95.7%]). Bimekizumab-treated patients achieved rapid improvements vs placebo in pain, fatigue, physical function and HRQoL by week 4, after a single dose. Improvements continued to week 16 for all patient-reported outcomes, including Pain Visual Analogue Scale (VAS; mean (95% CI) change from baseline: bimekizumab: –‍25.2 [–27.2, –23.1]; placebo:‍ –‍5.7 [–8.2, –3.3]) and FACIT-Fatigue (bimekizumab: 4.5 [3.9, 5.1]; placebo: 1.1 [0.3, 2.0]); both nominal p<0.001. Greater proportions of bimekizumab-treated patients achieved minimal clinically important differences for patient-reported symptoms vs placebo, including FACIT-Fatigue (bimekizumab: 53.1%; placebo: 36.3%) and HAQ-DI (bimekizumab:‍ 53.0%; placebo: 28.7%); both nominal p<0.001.ConclusionBimekizumab treatment demonstrated rapid and greater improvements in patient-reported pain, fatigue, physical function and HRQoL to week 16 vs placebo in bDMARD-naïve and TNFi-IR patients.Trial registration numberClinicalTrials.gov:NCT03895203;NCT03896581.
Long versus short-term opioid therapy for fibromyalgia syndrome and risk of depression, sleep disorders and suicidal ideation: a population-based, propensity-weighted cohort study
Authors: Hurtado Isabel , Robles Celia , Peiró Salvador , García-Sempere Aníbal , Llopis Fran , Sánchez Francisco , Rodríguez-Bernal Clara , Sanfélix Gabriel 
Published: September 2024

ObjectiveFibromyalgia syndrome (FMS) is characterised by widespread pain and is associated with mood disorders such as depression as well as poor sleep quality. These in turn have been linked to increased risk of suicidal ideation. Clinical guidelines generally do not recommended opioids in FMS, but they are routinely prescribed to a considerable proportion of FMS patients. We assessed the association of long-term opioid prescription for FMS with risk of depression, sleep disorders and suicidal ideation, when compared with short-term opioid use.MethodsRetrospective cohort study combing several population-wide databases covering a population of five million inhabitants, including all adults who received an initial opioid prescription from 2014 to 2018 specifically prescribed for FMS. We examined the occurrence of depression, sleep disorders or suicidal ideation outcomes in patients with an initial long-term opioid prescription (>90 days) versus those who received a short-term treatment (<29 days). We employed multivariable Cox regression modelling and inverse probability of treatment weighting based on propensity scores and we performed several sensitivity analyses.Results10 334 patients initiated short-term (8309, 80.40%) or long-term (2025, 19.60%) opioids for FMS. In main adjusted analyses, long-term opioid use was associated with an increased risk for depression (HR: 1.58, 95% CI 1.29 to 1.95) and sleep disorder (HR: 1.30, 95% CI 1.09 to 1.55) but not with suicidal ideation (HR: 1.59, 95% CI 0.96 to 2.62). In models assessing outcomes since day 90, an increased risk for suicidal ideation was observed (HR: 1.76, 95% CI 1.05 to 2.98).ConclusionThese findings suggest that continued opioid use for 90 days or more may aggravate depression and sleep problems in patients with FMS when compared with patterns of short-term treatment.
An investigation of subaqueous failures triggered by the 1935 CE Mw 6.1 Témiscaming earthquake, Quebec, Canada, as an analogue for a paleoseismic study
Authors: Brooks Gregory R. , Grenier Alain , Brewer Kevin 
Published: September 2024

Subaqueous mass transport deposits (MTDs) attributed to the Mw 6.1 1935 CE Témiscaming earthquake were mapped at 17 sub-bottom acoustic profile survey areas on 11 lakes near Témiscaming, Quebec. Distributed over about 1270 km2, MTDs are the product of shallow failures, up to several metres thick, that occurred along planar surfaces and involved primarily lacustrine sediments. Core samples of unfailed deposits indicate that the failure planes occurred within soft sediments at the top of a glaciolacustrine unit or at the base of overlying lacustrine deposits. Radioisotope dating of sediment samples from six coring sites on Tee and Kipawa lakes confirm that the MTDs are the product of failures triggered by the 1935 CE earthquake. To assess the application of such a mapping study to a paleoseismic investigation, the minimum magnitude of an earthquake that can generate an MTD distribution of 1270 km2 was extrapolated from a published empirical plot. The resulting magnitude of Mw/Ms 5.7–5.8 is less than the instrumental Mw 6.1 magnitude and deemed a reasonable estimation of minimum earthquake magnitude. The distribution of MTDs triggered by the 1935 CE earthquake forms the only such signature within the Témiscaming study area since roughly 8 ka cal B.P. The lack of an analogous, older signature(s) is consistent with the absence of equivalent shaking to the 1935 CE earthquake over this period, but the actual timespan may be shorter and begin when gyttja deposits on slopes became thick enough to be prone to failure from such an event.
Simulated warming reduced greenhouse gas emissions by lowering soil moisture in a Pinus tabulaeformis forest of the temperate zone
Authors: Yao Huifang , Feng Ru , Ma Xiuzhi , Li Xiaoyang , Feng Hui , Li Shunshun , Liang Lei , Han Xiaorong 
Published: September 2024

The forest soil carbon represents the largest carbon pool in the terrestrial ecosystem. To clarify the effect of climate warming on the soil carbon pool of a Pinus tabulaeformis plantation in the northern temperate zone, an open-top chamber was used to study the effects of warming on soil temperature and moisture, soil enzyme activity, soil active organic carbon, and greenhouse gas emissions in different soil layers. The results showed that (1) warming increased the temperature and decreased the moisture content of the atmosphere and soil. Atmospheric temperature increased by 0.9 °C on average, and atmospheric moisture decreased by 0.05%. The average annual temperatures of the surface soil (5 cm) and deep soil (40 cm) increased by 1.18 and 0.66 °C, respectively, and soil moisture decreased by 2.55% on average. (2) Warming had no significant effect on soil active organic carbon or enzyme activity, but had a significant effect on the active organic carbon content and enzyme activity in individual soil layers in individual months. For example, warming significantly altered the soil sucrase and catalase activities in the 10–20 cm soil layer in September, and also had a significant effect on readily organic carbon content in the 10–20 cm soil layer in July. (3) The seasonal variation of soil CO2 flux showed a unimodal pattern, peaking in July and, ranging from 116.75 to 420.45 mg·m−2·h−1. Warming reduced soil CO2 emissions from the control treatment, from 996.35 to 781.57 g·m−2. The soil of the P. tabulaeformis forest in Daqing Mountain is a sink of atmospheric CH4. The seasonal variation range is −32.34 to −76.43 µg·m−2·h−1, and the flux value is at its lowest in September. Warming promoted the absorption of soil CH4, and the seasonal absorption values of CH4 in the warming and control treatments were 172.03 and 136.90 mg·m−2, respectively. Therefore, after the short-term warming treatment, the soil moisture was reduced; greenhouse gas emissions were significantly reduced, and the warming formed a negative feedback with soil greenhouse gas flux.
Fission of $$^{180}$$Hg and $$^{264}$$Fm: a comparative study
Authors: Bernard Rémi N. , Simenel Cédric , Blanchon Guillaume , Lau Ngee-Wein T. , McGlynn Patrick 
Published: September 2024

Abstract$$^{180}$$

180

Hg is experimentally found to fission asymmetrically. This result was not expected as a naive fragment shell effects study would support the symmetric mode to be the most probable. In the present study we investigate both symmetric and asymmetric $$^{180}$$

180

Hg fission modes at the mean field level using various multipole moment constraints. Potential energy surfaces are analysed in terms of shell effects that shape their topographies and connections to fragment shell effects are made. The non-occurrence of low energy symmetric fission is interpreted in terms of $$^{90}$$

90

Zr fragment properties. Throughout this study a comparison with $$^{264}$$

264

Fm and its symmetric doubly magic $$^{132}$$

132

Sn fission fragments is done.
Influence of demagnetizing effects on the magnetization curves of finite-size rectangular slabs
Authors: Kiss L. F. , Varga L. K. , Gubicza J. , Péter L. , Bakonyi I. 
Published: September 2024

AbstractAccording to some recent studies, the magnetoresistance curves of ferromagnetic strip-shaped samples can significantly differ depending on whether the in-plane external applied magnetic field H is oriented in parallel to either the long or the short edge of the strip. To address this problem, in the present work magnetization curves M(H) were measured for similarly shaped samples with both magnetic field orientations used in the magnetoresistance measurements. It was found that the M(H) curves strongly depend on the saturation magnetization and shape of the samples as well as on the magnetic field orientations. For some samples with sufficiently large saturation magnetization, the effective demagnetizing factors could be deduced from the measured M(H) curves. By considering the investigated samples as a ferromagnetic slab, and approximating them with a general ellipsoid, the demagnetizing factors were calculated from known formulae and compared to the experimental values. A fairly good matching was observed, although the latter data were systematically slightly larger, certainly due to the not completely homogeneous magnetization within the rectangular slab as opposed to the case of a general ellipsoid. The differences in the M(H) curves for the two orientations of the magnetic field could be completely attributed to demagnetizing effects.
Effect of High-Temperature Operation on Voltage Cycling Induced PEMFC Degradation: From Automotive Customer Drive Cycles to an Accelerated Stress Test
Authors: Trogisch Niklas , Babik Danilo , Orfanidi Alin , Jegert Gunther , Albert Albert , Eichel Rüdiger-A. 
Published: September 2024

Degradation of the Pt catalyst during load cycling constitutes a major durability issue for proton exchange membrane fuel cells (PEMFCs) in automotive applications. In this study commercial 5 cm2 electrodes were exposed to 20 k voltage cycles between 0.6–0.9 VRHE at temperatures ranging from 75 to 120 °C. The electrochemical surface area (ECSA), the roughness factor (rf), and the oxygen transport resistance were investigated over the course of the test. The degradation was mainly governed by Pt agglomeration and was accelerated with increasing temperature. Interestingly, operation at high temperature (120 °C and 30% RH) caused the same ECSA loss as at standard conditions (90 °C and 90% RH), suggesting that when maintaining dry conditions high-temperature operation is not critical for the durability of the catalyst material. The experimental results were used to validate an existing 0D catalyst degradation model, which was then applied to an automotive customer drive cycle. The calculated degradation over the whole automotive lifetime (excluding startup shutdown and idle events) equals 20 k voltage cycles (0.6–0.9 V, 10 s hold time) at 90 °C and 30% RH, which provides a guideline for the assessment of the suitability of novel catalyst materials for automotive applications.
A Piano for Visuals: Affordances of Scan Processing Instruments
Authors: Holzer Derek 
Published: September 2024

Abstract
The analog technology of scan processing was developed and used during the 1970s as a means of electronic image animation. Because their real time modes of operation strongly resemble those of electronic music instruments, scan processors can be considered instruments for composing and playing moving images. Despite being replaced by cheaper digital tools in commercial studios during the 1980s, scan processing has a distinctive aesthetic that continues to inspire both visual artists and instrument designers. This article examines how the affordances of scan processing instruments arise from specific combinations of user, technology and situation by surveying a number of technical and artistic use cases involving two different instruments: the VP-8 Image Analyzer and the Rutt/Etra Video Synthesizer. The article also demonstrates how reenacting an instrument works through its historical affordances using current technological means to address contexts of the present day.
Passage of Water: Artistic Exploration of Earth’s Freshwater with Google and NASA
Authors: Kang Yiyun , Choi Jeanyoon 
Published: September 2024

Abstract
Passage of Water is Yiyun Kang’s artwork in collaboration with Google Arts & Culture and NASA to highlight the significance of freshwater. Kang uses the datasets and scientific expertise that NASA satellites and scientists provide and employs immersive storytelling and audiovisual techniques to address the climate crisis and its impact on freshwater. The Passage of Water web artwork was launched on the Google Arts & Culture platform on 30 November 2023. Author Kang then adapted the online experiment to an in-person exhibition at the 28th United Nations Climate Change Conference of the Parties (COP28) Dubai, UAE, from 30 November to 12 December 2023.
UrbanAI Art: Toward Artist-Driven AI Art
Authors: Lahtinen Jussi , Oksanen Atte 
Published: September 2024

Abstract
UrbanAI Art is based on the concept of artist-driven artificial intelligence (AI) art. Acknowledging the potential of AI, artists use their work as input, and they manage the overall concept and production of artist-oriented, concept-oriented, and unique artwork. Hence, each artist-driven AI art piece is distinctive and original. UrbanAI Art by Jussi Lahtinen is based on his Metropolis series (2015–) and is built from code that he developed together with game designers at Moido Games, especially Henri Sarasvirta. UrbanAI Art was released in spring 2023, and has since been screened at major events in Europe.
(Nip)ulations: The Nipulator Electronic Bra and the Embodiment of the Image Processing Tool
Authors: Panzarino Monica 
Published: September 2024

Abstract
The Nipulator electronic bra is a custom-built, wearable device that uses hardware potentiometers (or knobs), a hacked DJ Hero microcontroller, and Cycling ’74 Max/MSP/Jitter software patches to (nip)ulate the author’s voice and/or image in real-time. The bra functions both as an instrument for live video and sound processing as well as feminist art object, and has been featured in several single-channel videos, and performances for an audience. This essay discusses how the author’s work with rare and historically significant image and sound processing tools like the Sandin Image Processor, Jones Frame Buffer, and Paik/Abe Raster Manipulation Unit (aka “Wobbulator”), influenced the creation of The Nipulator, as well as her experimental media art practice more generally. Other artistic, feminist, and personal influences are also considered, and a thorough description of the bra’s design, technical evolution, and challenges with regards to durability is provided.
ℓ
1
-Regularized ICA: A Novel Method for Analysis of Task-Related fMRI Data
Authors: Endo Yusuke , Takeda Koujin 
Published: September 2024

Abstract
We propose a new method of independent component analysis (ICA) in order to extract appropriate features from high-dimensional data. In general, matrix factorization methods including ICA have a problem regarding the interpretability of extracted features. For the improvement of interpretability, sparse constraint on a factorized matrix is helpful. With this background, we construct a new ICA method with sparsity. In our method, the ℓ1-regularization term is added to the cost function of ICA, and minimization of the cost function is performed by a difference of convex functions algorithm. For the validity of our proposed method, we apply it to synthetic data and real functional magnetic resonance imaging data.
Orthogonal Gated Recurrent Unit With Neumann-Cayley Transformation
Authors: Zadorozhnyy Vasily , Mucllari Edison , Pospisil Cole , Nguyen Duc , Ye Qiang 
Published: September 2024

Abstract
In recent years, using orthogonal matrices has been shown to be a promising approach to improving recurrent neural networks (RNNs) with training, stability, and convergence, particularly to control gradients. While gated recurrent unit (GRU) and long short-term memory (LSTM) architectures address the vanishing gradient problem by using a variety of gates and memory cells, they are still prone to the exploding gradient problem. In this work, we analyze the gradients in GRU and propose the use of orthogonal matrices to prevent exploding gradient problems and enhance long-term memory. We study where to use orthogonal matrices and propose a Neumann series–based scaled Cayley transformation for training orthogonal matrices in GRU, which we call Neumann-Cayley orthogonal GRU (NC-GRU). We present detailed experiments of our model on several synthetic and real-world tasks, which show that NC-GRU significantly outperforms GRU and several other RNNs.
KLIF: An Optimized Spiking Neuron Unit for Tuning Surrogate Gradient Function
Authors: Jiang Chunming , Zhang Yilei 
Published: September 2024

Abstract
Spiking neural networks (SNNs) have garnered significant attention owing to their adeptness in processing temporal information, low power consumption, and enhanced biological plausibility. Despite these advantages, the development of efficient and high-performing learning algorithms for SNNs remains a formidable challenge. Techniques such as artificial neural network (ANN)-to-SNN conversion can convert ANNs to SNNs with minimal performance loss, but they necessitate prolonged simulations to approximate rate coding accurately. Conversely, the direct training of SNNs using spike-based backpropagation (BP), such as surrogate gradient approximation, is more flexible and widely adopted. Nevertheless, our research revealed that the shape of the surrogate gradient function profoundly influences the training and inference accuracy of SNNs. Importantly, we identified that the shape of the surrogate gradient function significantly affects the final training accuracy. The shape of the surrogate gradient function is typically manually selected before training and remains static throughout the training process. In this article, we introduce a novel k-based leaky integrate-and-fire (KLIF) spiking neural model. KLIF, featuring a learnable parameter, enables the dynamic adjustment of the height and width of the effective surrogate gradient near threshold during training. Our proposed model undergoes evaluation on static CIFAR-10 and CIFAR-100 data sets, as well as neuromorphic CIFAR10-DVS and DVS128-Gesture data sets. Experimental results demonstrate that KLIF outperforms the leaky Integrate-and-Fire (LIF) model across multiple data sets and network architectures. The superior performance of KLIF positions it as a viable replacement for the essential role of LIF in SNNs across diverse tasks.
New species and new records of Indonemoura (Plecoptera: Nemouridae) from Xizang of southwestern China
Authors: LIU DONGXIA , YANG DING , LI WEIHAI 
Published: September 2024

A new species of stonefly (Plecoptera: Nemouridae), Indonemoura sejila sp. n., is described from the Xizang Autonomous Region and the affinities towards a similar species, I. nigrihamita concava Li & Yao, 2017, is discussed. Indonemoura geminus Zwick, 1977 and I. indica (Kimmins, 1947) are recorded from China for the first time.
Process-Based Evaluation of Intraseasonal Oceanic Kelvin Waves in the Pacific Ocean in CMIP6 Models
Authors: Cui Jingxuan , DeMott Charlotte , Riley Dellaripa Emily , Maloney Eric 
Published: September 2024

Abstract
Oceanic intraseasonal Kelvin waves (KWs) help modulate upper-ocean thermal characteristics, providing feedbacks to important coupled air–sea phenomena in the tropics. The recent availability of daily thermocline depth fields from several phase 6 of the Coupled Model Intercomparison Project (CMIP6) models makes it possible to evaluate the performance of KWs and identify potential sources of bias. Most models fail to simulate a realistic spatial distribution of KW variability. Models simulate a large variability of KWs in the western or eastern Pacific rather than in the central Pacific as observed. The modeled KWs propagate slowly (about 1.5 m s−1) compared to observations (about 2.5 m s−1). This slow propagation is also identified in wavenumber–frequency spectra for KWs and meridional KW structures, which is more consistent with a second baroclinic mode structure in models compared to the first baroclinic mode structure in observations. An analysis of the relative contributions of the vertical wavenumber and background ocean stability to KW phase speeds indicates that the high vertical wavenumber bias in models contributes most to the slow propagation, in which the higher-than-observed vertical wavenumbers imply the biased incorporation of higher baroclinic modes in the model KW structure. This finding is further supported by the results of vertical mode decomposition that incorporates background density profiles. These results indicate that a realistic representation of the KW vertical structure is essential to produce realistic KW propagations in models.

Significance Statement
Oceanic intraseasonal Kelvin waves (KWs) play a significant role in regulating the heat content and temperature of the ocean, which provides feedbacks to coupled ocean–atmosphere phenomena in the tropics such as El Niño–Southern Oscillation (ENSO). Consequently, identifying the biases in KWs and the potential sources of those biases in state-of-the-art models is essential to improve simulations of ENSO and its diversity and advance forecasts of weather extremes around the globe induced by ENSO. We find that KWs in the models propagate slower than observations, mainly due to biases in their vertical structure, with secondary effects due to biases in model ocean stability. These issues may be potential sources for current imperfect ENSO model simulations and predictions.