bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of Epidermal Growth Factor, Tumor Necrosis Factor-alpha and Thioredoxin System in Rats Exposed to Cerebral Ischemia
Authors: Erol-Demirbilek Melike , Kilic Nedret , Komurcu Hatice Ferhan 
Published: October 2016

Abstract
Background: Thioredoxin reductase (TrxR), epidermal growth factor (EGF) and tumor necrosis factor-α (TNF-α) have neuroprotective/neurotoxic effects in cerebral ischemia. We aimed to investigate the TrxR activity, EGF and TNF-α levels in cerebral ischemic, sham-operated and non-ischemic rat brains.
Methods: Sprague-Dawley rats divided into three groups. Rats in control group were not subjected to any of treatments and their brains were removed under anesthesia. Middle cerebral arters were exposed but not occluded for the sham-operated rats. Animals were subjected to permanent middle cerebral arter occlusion (MCAO) in MCAO-operated group. The rats were decapitated at 16 hours (h), 48 h and 96 h after sham operation and focal cerebral ischemia. TrxR activities, EGF and TNF-α levels were measured in ischemic and non-ischemic hemispheres for all groups.
Results: In group MCAO, TrxR activities were significantly low at 48 h in ischemic hemisphere in comparison to control. After the 48 h, a remarkable increase was observed at 96 h. EGF and TNF-α levels were substantially high at 96 h in group MCAO of ischemic brain.
Conclusion: TrxR activity was reduced by oxidative stress which was formed by ischemia. EGF levels increased to exhibit neurotrophic and neuroprotective effects. After ischemia, TNF-α levels increased as a response to the tissue damage. Further studies with a higher number of experimental subjects and shorter or longer periods such as from first 30 minutes up to 3 months may be more informative to show the time-dependent variations in TrxR, EGF and TNF-α in cerebral ischemic injury.
Chronic myelomonocytic leukemia “myelodysplastic type’’ in transformation to acute myeloid leukemia – diagnostic and therapeutic options: case report and literature review / Leucemie mielomonocitară cronică forma mielodisplazică în transformare spre leucemie acută mieloidă – diagnostic și opțiuni terapeutice: prezentare de caz și revizuirea literaturii
Authors: Cîrstea Mihaela , Coliță Adriana , Ionescu Bogdan , Vasilache Didona , Dobrea Camelia , Jardan Cerasela , Dragomir Mihaela 
Published: October 2016

Abstract
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell disorder that is characterized by the presence of an absolute monocytosis (1 × 10^ 9/l) in the peripheral blood, the overlap of myelodisplastic aspects and myeloproliferative aspects in the bone marrow and tendency to transform into acute myeloid leukemia. CMML is considered to be the most aggressive chronic myeloid leukemia. We present the case of a 48 years old woman who was hospitalized in March 2013 in the Center of Hematology and Bone Marrow Transplantation for anemia related symptoms. Initial investigations showed anemia, relative monocytosis (10% monocytes of the WBC differential) with an increasing absolute number of monocytes (> 1,000/μl) in the following months. Initial exploration of the bone marrow (aspirate and bone marrow biopsy and immunohistochemistry IHC tests) revealed elements of trilinear dysplasia and an increased percentage of myeloblasts (11-14%). In the next four months myeloblasts percentage remained below 20% (8-14%) and it has been observed a gradually increasing of monocytoid elements (> 20%). Immunophenotyping in the bone marrow aspirate identified a monocytic proliferation with high percentage (8%) of immature cells. The karyotype reported the presence of clones with t (1;3). Initially diagnosed as RAEB-2 (WHO) the case was recomitted in CMML-type 2 with a progression to acute myeloid leukemia (AML). Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been performed after getting the best possible therapeutic response with AML chemotherapy type (complete remission). Allo-HSCT was performed using myeloablative conditioning, 12 months after diagnosis. The patient is now in complete remission, 24 months after allo-HSCT.
Structure life forms of the species of the family Plantaginaceae
Authors: Hrytsyna M. R. 
Published: October 2016

In the article is conducted an analysis of structure of life–form of types of species of the genus Veronica and shallow families of Callitrichaceae and Plantaginaceae is for determination of criteria of their associacion in new family of Plantaginaceae, distinguished in molecular–phylloginatec system APG ІІІ. Based on molecular–phylloginatec explorations the family of Scrophulariaceae collide on seven monophyletic clade. Veronicaceae clade is one of the biggest line orders Lamiales, now it is rised to the rang of the family and named Plantaginaceae. Molecular researches confirmed integrity of clade on a 98%. System APG operates only monophyletic units, that causes her considerable differences from evolutionary – morphological. Therefore, at the construction of the new system is necessary to take morphological, ecological features and principles of evolutionary systematization into account. We have learnt the most wide types of families of the life form structure, such as Veronicа, Callitrichace, Plantaginо. Veronica chamaedrys can be refered to types of sympodial creeping longrooted, herbal polycarpic aklonalnyj types life–form, with anizotropical, monopodial, non–rosette monocarpic shoots and by frondozed inflorescence. Veronica serpyllifolia that is creeping rooted of few (3 – 4) year life forms aklonalnyj types with non–rosette, anisotropy, monocarpial monopodial shoots, which gradually moving to tasssels. At the brought weed plant of Veronica persica during one year the life–form of rodrooted is formed clone form renascent with the anisotropic type of extended monocarpical of monopodial shoots. Similarity of structure of flower, in particular stamen vehicle, reduction of duration of life cycle from perennial to little old and annual plant to unite these species in one clade ad. However, development of life form depends anymore on the terms of environment, than genotype. While generative area of plant is more conservative.
The iodine content of the soil and cereals in the area of the Woodlands
Authors: Hunchak R. V. , Sedilo H. M. , Vovk S. O. 
Published: October 2016

Because of the natural laws of the chain «soil–plant–animal» trace element status of pigs in the conditions of industrial technology of cultivation depends on the quantity and value of various macro– and microelements in feed, which is the result of absorption from the soil. Among feed factors, one of the limiting micronutrient is iodine. We, in terms of Farm «Amila» Turiysk district, Volyn region, investigated levels of iodine in the grain group of plants (barley, triticale, oats, rye), which is used to feed pigs as fullcomponent feed, depending on the accumulation of trace elements in the soil. It was established that the average iodine content in sod–podzolic soils (36% of all arable land) farms located within 7.48 ± 0.46 mg/kg, clay and sand 5.6 ± 0.38 mg/kg and gley–sandy – 5.96 ± 0.67 mg/kg. Thus, the study of grain grown on these lands have shown that the level of iodine in them was low and ranged from 49 to 77 mg/kg. Given the data provided to us agrochemical analysis of soil (the humus, pH, exchange nitrogen, mobile forms of manganese, zinc, copper, iron, cobalt, boron and sulfur), it was found that the pH of the soil on the farm was, on average, at 6.1 – 7.5 humus content – 2% – 3%, nitrogen – 48 – 72 mg/kg. In the majority of areas in the studied soils found very high boron content (> 0.7 mg/kg) and very low concentration of copper (<0.11 mg/kg) and iron (<0.08 mg/kg). Amid moderate soil providing mobile forms of the investigated macro– and microelements (N, Mn, Zn, S) detected an imbalance in the concentration of B, Cu, Fe, is likely to affect the concentration of iodine in soil fixing its potential, which in turn depends on ability to maintain atomic iodine and facilitate its absorption. It is possible that the rate of absorption of iodine from the soil under these conditions is also insufficient. Taking into account the available information on the specific components of iodine in the diet to ensure the body metabolism pigs must decide on the further introduction of easily accessible iodine–containing drugs.
Reppoductive ability of ukrainian black and white dairy cows
Authors: Kuziv M. I. , Fedorovych E. I. 
Published: October 2016

The major components of economically useful traits in cattle dairy productivity, which conducted the selection is milk productivity and reproductive ability of cows. Studies conducted on animals Ukrainian black and white dairy cattle in the «Milk River» farm in the Sokal and Brody offices breeding reproducers «Breeder» Lviv region and plant breeding «Yamnytsya» Ivano–Frankivsk region. Ukrainian black and white dairy breed in the western region of Ukraine is characterized by good reproductive ability. Depending on the husbandry and lactation duration, service period lasted within 87.4 – 121.5 day, intercalving period – within 364 – 402.6 day, dry period within – 47.3 – 72.9 day, the fertility index was 46.3 – 48.0, coefficient of reproductive ability – within 0.92–0.99, output of calves per 100 cows – within 91.8 – 98.8. The duration of pregnancy in cows of different farms and lactations were in range 277 – 283.5 day and meet the requirements of the physiological norm. It has been shown that the milk yield of cows depends on the parameters of reproductive capacity. The correlation between duration of service–period and intercalving period, and milk yield, milk fat in most cases was positive. Correlation dry period duration and parameters of milk yield changed from negative to positive. Depending on the husbandry, lactation and index the impact share of service–period duration on milk yield was 7.0 – 29.7, for intercalving period – 8.8 – 31.8, for dry period – 9.2 – 23.8% respectively.
Effect of feeding sows PVMA Intermiks on digestibility and metabolism of pigs
Authors: Lyubasyuk N. V. 
Published: October 2016

Pork production in modern conditions associated with the use of feed and dietary supplements as part of diets, because without them to provide animals essential nutrients almost impossible. Especially for little Ingredient grain rations. Therefore have resorted to creating new PVMA. These concerns and PVMA Intermiks PS – 7.5% and Intermiks LS – 20% – according to gestation and lactating sows. So were conducting research on the influence of feeding PVMA Intermiks sows in different periods of the reproductive cycle of feed digestibility and metabolism of nitrogen, calcium and phosphorus in their piglets weaned at 28 days age. Research groups conducting two–analogues pigs of large white breed balance method, under which the pigs were kept in individual cages and accounted for eight days consumed feed, feces and urine color. The live weight per head was 9 kg. Sows experimental group during 85 days gestating 7.5% by weight was replaced grain mix PVMA Intermiks PS, and next to farrowing and weaning piglets at 28 days age, replaced 20% concentrated feed on PVMA Intermiks LS. Sows in the control group were kept in complete feed appropriate. After all born piglets up to 14 days eating a special supplement Intermiks SP «Bambino» – 25%, and from 14 to 28 days – Intermiks SP – 25%. Studies have shown that feeding sows PVMA Intermiks increases performance polycarpous 10.8% weight in the pig–breeding nests by 25.3% and 13.3% macrocarpa. The weight of a piglet at birth the control and the experimental groups was 1.05 and 1.19 kg and at weaning at 28 days of life – 8.52 and 9,1 kg. Piglets from sows receiving PVMA Intermiks had higher levels of digestibility of crude oil (3.3%) and fiber (to 5.37%). No significant difference was obtained for the digestibility of dry, organic matter and protein compared to piglets from sows with complete feed in the diet. In the experimental pigs tends to increase the number of nitrogen retained in the body (14.5 %) and from the accepted and digested (by 4.4 and 6.0%). Terms feeding lactating sows gestation and no likely impact on calcium and phosphorus in pigs weaned at 28 days age.
Ecological and Agrochemical Certification Farm and Forage Land of Agricultural Enterprises in Ternopil region, Berezhany District LLC «Zhyva Zemlia Potutory» and LLC «Krona»
Authors: Pavliv A. V. 
Published: October 2016

Ecological and agrochemical certification of farm land and forage landof such agriculturalenterprises as LLC «Zhyva Zemlia Potutory» in the village of Potutory, Berezhany district, Ternopil region and LLC «Krona» in the village of Zhukiv, Berezhany district, Ternopil region has been conducted. Soil has been characterized according to the content of humus, nitrogen (which is easily hydrolyzed), moving phosphorus, exchange potassium, moving type of sulphur as well as according to the soil acidity (pH and hydrolytic). The dynamics of weight indices of the main agrochemical characteristics of ashen–gray soil have been determined. It has been determined, that the indices have greater variability at the level of a separate field and it is less at the level of an enterprise. Having analyzed the indices of the agrochemical state of the soil of farm land and forage land of such agricultural enterprises as LLC «Zhyva Zemlia Potutory» in the village of Potutory, Berezhany district, Ternopil region and LLC “Krona”in the village of Zhukiv, Berezhany district, Ternopil region, is has been determined, that the soil have satisfactory agrochemical properties and are characterized by optimum conditions for growing crops and obtaining full value yields. The limiting factor is low content of nitrogen, which is easily hydrolyzed.
Modern aspects of operation liner teat cups
Authors: Paliy A. P. 
Published: October 2016

Major traumatic effect in milking cows has liner teat, a structural element of the milking cup. Tires that do not meet the requirements during milking animals may rub the nipple to corns and often causes bleeding, and is a peddler of disease, as are cracks rubber breeding sites of infection, which affects the quality of milk and often causes mastitis. An improved method of diagnosing performance properties liner teat milking cups is done as follows: using metering unit is working length rubber. Then make measurement extension product in tension under the weight of 6 kg, which occurs within 60 seconds, and exercise determine deformation sucker. The next phase is carried calculation of the duration of use liner in days (T), taking into account the number of milking machines in milking installation (к), frequency of milking herds per day (m) and the number of cows in the herd, which caters milking unit (n). After making these measurements and calculations, the results are interpreted as follows: liner teat milking cups usable only if its elongation under a load of 6 kg not exceeding 5 mm, deformation of the suction cup is in the range from 0 mm to 3 mm. If the life of the liner, as calculated by the formula is more than 185 days, it replaced no later than 6 months of operation. Scientific and economic experiments established that the introduction given by way of selection, condition monitoring and timely replacement liner teat milking cups enhances the intensity milk output 5.2 – 7.5%, decrease in the duration of the milking by 8.0 – 10.5%, disease of cows to mastitis to 8,5%. Implemented research and development will allow for broader studies that focus on technological process of machine milking cattle. Further findings will create prerequisites for optimum interaction liner teat milking cups from the udder of animals.
Features of growth of the living mass of different ukrainian black–spotted lines dairy cows breed during the period of their breeding
Authors: Poslavska Yu. , Fedorovych E. , Bodnar P. 
Published: October 2016

The article presents data concerning the dynamics of living mass growth of different Ukrainian Black–Spotted dairy cows breed during their growing in certain age periods (n = 2357): newborns, 6–, 12–, and 18 months. The studies were conducted in conditions of LLC «Molochni riky» Sokalj district, Lviv region. Living mass of the animals was determined on the basis of primary zootechnical accounting (within the past 30 years). It was established that cows from the investigated lines of Ukrainian Black–Spotted breed during their growing were distinguished by the indexes of living mass and average daily rates in certain age periods. The indicated figures in all investigated age periods were higher in animals lines: Starbuck 352790, Reflection Sovereign 198998, Eleveish 1491007, Annas Adem 30587 Athlete and 4098. In the live weight of newborns heifers these lines are within 32.3 – 34.2 at 6 months of age – within 177.5 – 182.4 kg, at 12–months – within 293.0 – 298, and 18 months – within 400.7 – 417.4. It should be noted that this indicator in all age periods of animals in specified lines was higher than the breed standard. The lowest rates of living mass in the search age periods were characterized animal lines of Astronauts 1458744, Siling Traijune Rokita 252803 and Butmaker 1450228. This indicator in them at the age of 18 months, ranged from 368.5 to 374.3 kg and was lower than the standard of Ukrainian Black–Spotted dairy breed on 5.7 – 11.5 kg. The dispersion analysis has shown, that the proportion of the influence of linear belonging of cows on the indicators of the living mass during growing ranged from 14.32 to 24.14%, whereby to the age of animals it is growing.
Evaluation of quality and safety of milk on admission to molokokopererobne company from different entities
Authors: Prilipko T. , Bukalova N. 
Published: October 2016

The work was performed under conditions of JSC «Gorodenkovskiy cheese» Ivano–Frankivsk region. Ob'yektom study was raw milk that came from different entities. Milk studied organoleptic and laboratory methods for conventional methods. Navedeni results of the study parameters of quality and safety of milk, which reported on molokokopererobne company from different entities, collective farms, private farms. The studies have shown that milk from entities in milk business reported first grade from private farms – the second, as evidenced by indicators titrated acidity – 17.5 ± 0.56 ºT and 19.3 ± 0.4 ºT respectively. Milk from individual farms to milk processing company reported non–refrigerated – 14.1 ± 0.5 ° C, cooled entities with an average temperature 8.3 ± 0.1 °C, which is likely to affect its quality. Density commodity raw milk obtained from farms of different ownership did not differ significantly (P < 0.05) fat 3.5 ± 0.25%, protein and 3.0 ± 0.07, than in samples obtained from entities that can be oznakoyuyoho alleged fraud, or increased stress on the metabolism. To guarantee the safety of milk producers should be used as raw material control system at all levels of the food chain, starting with control of mineral fertilizers and plant protection products in pastures, sources of water intake, health and welfare and finishing, storage and transportation milk processing enterprises
Reaction of stomach for feeding young pigs probiotics
Authors: Trachuk E. G. , Farionik T. V. 
Published: October 2016

The basis for the diets of pigs of different technologies of production and productivity in all areas and forage species are of plant origin, which is associated primarily with their availability. This group consists of feed grain cereals, grain legumes, green coarse, juicy, waste flour and other technical industries and others. Although omnivorous pig feed them digestion features displayed on the feasibility of forming foundations diet of concentrated feed. For industrial production of pork proportion of concentrated feed often 100%. However, partly in used feed feeding that are of poor quality, which in turn worsens their nutritional value and complicates digestion and nutrient absorption of food. Besides the low digestibility of grain mixtures in which a third of organic matter is not absorbed by the animals, lack of nutrients adversely affect the resistance and other reactions, reproductive function and performance. Studying the formative influence of the new feed factor on the structure of the digestive system of animals must pay attention to the morphological features of individual organs as the result of direct exposure to chemicals in the diet of the wall of the gastrointestinal tract. The effect of different doses of probiotic preparation Entero–active in growing young pigs on morphological indicators of cardiac, fundic and pyloric stomach areas and established its laws. The data indicate a probable thickening of the stomach wall for probiotic action by thickening muscle and mucous membranes in all investigated areas. The changes have no pathological character, and show an adaptive response to the action of gastric certain doses of the new feed factor.
The influence of alimentary factors on productivity hens
Authors: Kyryliv B. Ya. , Hunchak A. V. 
Published: October 2016

In the process of ontogenetic development chickens determined appropriate age periods characterized by inhibition of metabolism. These changes are most clearly observed changes during the primary feathers on second (main), and at the age preceding puberty and lead to lower projected laying hens. Therefore there is a need for correction of metabolic processes in the body of young birds by using biologically active substances.The results of studies on the efficiency in feeding of young chickens egg productive direction sulfate and polyenzyme drug «Natuzym». It is shown that in comparison with those of control group in poultry, the introduction into the diet of chickens egg productive direction cross «Hayseks brown» Sodium Sulphate with 10 days old and polyenzyme drug «Natuzym» of 20– to 40–day and 80–110 –days age led to an increase in average daily increments calves and body weight at the beginning of entry of birds. The positive effect of additives on the performance puberty of birds. The difference between age of first egg demolished bird control and experimental groups of four days. Later chickens experimental group also characterized higher ripening indicators such as age reaching 50% egg age and achieve peak performance. In particular, the difference of analog control group was 2 days. Was higher and egg chickens 18.53 pc. eggs per laying hen high. In this group of bird egg shell weight and his strength were higher compared with those in the control, respectively, 9.23% and 9.26% (P <0.05). However, biological and food quality was improving of eggs obtained by increasing the content of carotenoids, vitamins A and E (P <0.05) and soluble protein (P <0.001)
ПРОБЛЕМИ УПРАВЛІННЯ ЯКІСТЮ НА ПІДПРИЄМСТВАХ В УМОВАХ ВХОДЖЕННЯ УКРАЇНИ В ЄС
Authors: Vovk M. 
Published: October 2016

У статті висвітлено особливості управління якістю продукції у вітчизняних підприємствах в аспекті міжнародних і національних трансформаційних процесів. Розглянуто головні тенденції нових підходів до управління якістю та способів контролю якості. Досліджено розвиток систем управління якістю продукції, а також обґрунтовано принципи формування і функціонування систем якості та необхідність їх впровадження в практичну діяльність вітчизняних підприємств. Доведено, що одним із найважливіших стратегічних питань реформування економіки України та її адаптації до вимог Європейського Союзу, є визначення перспективних напрямів управління виробництвом, зокрема управління якістю продукції. Для цього проаналізованоосновні вимоги законодавства ЄС до безпеки та якості товарів. Першочергове завдання, яке стоїть перед керівництвом підприємства,єрозробка заходів щодо впровадження на практиці сертифікованої системи якості, що в свою чергу забезпечить високий рівень довіри у споживачів і партнерівстосовно якості продукції і виробничого процесу, а також підвищить ефективність діяльності підприємства загалом.
Запропонованонапрями покращення управління якістю виробництва продукції на підприємстві при виході на зовнішні ринки шляхом побудови інтегрованих систем управління якістю.