bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Reduction of Aryl Halides into Arenes with 2‐Propanol Promoted by a Substoichiometric Amount of a tert‐Butoxy Radical Source.
Authors: Ueno Ryota , Shimizu Takashi , Shirakawa Eiji 
Published: July 2016

AbstractThe reaction has a broad substrate scope, thus tolerating e.g. heteroarenes and chloro or alkyne functionalized arenes, and may be adjusted to the transformation of sensitive bromoarenes, including alkene‐, keto‐ and cyano‐group containing ones.
ChemInform Abstract: Enantioselective Decarboxylative Arylation of α‐Amino Acids via the Merger of Photoredox and Nickel Catalysis.
Authors: Zuo Zhiwei , Cong Huan , Li Wei , Choi Junwon , Fu Gregory C. , MacMillan David W. C. 
Published: July 2016

AbstractAn enantioselective, decarboxylative C(sp3)—C(sp3) cross‐coupling reaction of α‐amino acids with aryl halides by synergistic iridium‐photoredox and nickel catalysis is presented.
ChemInform Abstract: Facile Preparation of Functionalized 1‐Substituted Cycloalkenes via an Iodine Atom Transfer Radical Addition—Elimination Process.
Authors: Meyer Daniel , Vin Estelle , Wyler Benjamin , Lapointe Guillaume , Renaud Philippe 
Published: July 2016

AbstractA scalable conversion of methylenecycloalkenes into 1‐substituted cycloalkenes (endo product), which are isolated together with minor amounts of their cycloalkylidene isomers (exo product), is described.
ChemInform Abstract: Three‐Component Reaction Between N‐Methylimidazole and Activated Acetylenes in the Presence of Kojic Acid or 8‐Hydroxyquinoline as CH‐Acids
Authors: Pahlavan Pedram , Hassanabadi Alireza 
Published: July 2016

Abstractaffording 2,3‐dihydroimidazoles with good yields under neutral reaction conditions
ChemInform Abstract: α‐Amino Aldehydes as Readily Available Chiral Aldehydes for Rh‐Catalyzed Alkyne Hydroacylation.
Authors: Hooper Joel F. , Seo Sangwon , Truscott Fiona R. , Neuhaus James D. , Willis Michael C. 
Published: July 2016

Abstractα‐Amino aldehydes, incorporating a methylthiomethyl protecting group on nitrogen, are efficient substrates in Rh‐catalyzed alkyne hydroacylation reactions.
ChemInform Abstract: [1 + 1 + 1] Cyclotrimerization for the Synthesis of Cyclopropanes.
Authors: Manna Srimanta , Antonchick Andrey P. 
Published: July 2016

AbstractThe copper‐catalyzed [1+1+1] cyclotrimerization of acetophenone derivatives affording a wide range of highly substituted cyclopropanes under mild reaction condition is reported for the first time.
ChemInform Abstract: An Air‐Stable Half‐Sandwich RuII Complex as an Efficient Catalyst for [3 + 2] Annulation of 2‐Arylcyclo‐2‐enones with Alkynes.
Authors: Zhao Yinsong , He Zhen , Li Shiqing , Tang Junbin , Gao Ge , Lan Jingbo , You Jingsong 
Published: July 2016

AbstractA novel ruthenium complex HSRC is prepared and successfully applied for the synthesis of spiro carbocyclic indenes via a [3 + 2] annulation strategy.
ChemInform Abstract: Copper‐Catalyzed Intermolecular Hydroamination of Internal Alkynes with Anilines and Amines.
Authors: Ishikawa Tomoki , Sonehara Taro , Minakawa Maki , Kawatsura Motoi 
Published: July 2016

AbstractAlkynes bearing a terminal trifluoromethyl group are treated with aryl amines under conditions A), i.e.
ChemInform Abstract: Polystyrene Resin‐Supported CuI‐Cryptand 22 Complex: A Highly Efficient and Reusable Catalyst for the Formation of Aryl—Sulfur Bonds in Aqueous Media.
Authors: Rezaei Nasrin , Movassagh Barahman 
Published: July 2016

AbstractThe cross‐coupling reaction of aryl halides and thiols in aqueous media is efficiently catalyzed by the air and moisture stable title catalyst (PCU).
ChemInform Abstract: Metal‐Free Direct Nucleophilic Perfluoroalkylthiolation with Perfluoroalkanesulfenamides.
Authors: Glenadel Quentin , Bordy Mathieu , Alazet Sebastien , Tlili Anis , Billard Thierry 
Published: July 2016

AbstractAnions generated in situ from perfluoroalkanesulfenamides undergo direct metal‐free nucleophilic substitution reactions with a wide range of alkyl halides to form the corresponding products.
ChemInform Abstract: Novel and Potent Lewis Acid Catalyst: Br2‐Catalyzed Friedel—Crafts Reactions of Naphthols with Aldehydes.
Authors: Liang Deqiang , Li Jingjing , Li Yanni , Wang Baoling , Cheng Ping , Luo Sha 
Published: July 2016

AbstractIt is shown that Br2 can act as a catalyst in Friedel—Crafts reaction of naphthols.
ChemInform Abstract: An Efficient Approach to Bis‐benzoquinonylmethanes on Water under Catalysis of the Bio‐Derived O‐Carboxymethyl Chitosan.
Authors: Asghari‐Haji Fatereh , Rad‐Moghadam Kurosh , Mahmoodi Nosrat O. 
Published: July 2016

AbstractThe title compounds are efficiently prepared under mild and metal‐free conditions by reaction of the naphthalene‐dione derivative with various aromatic aldehydes using carboxymethyl chitosan as a green, available, cheap, and water‐soluble bio‐derived catalyst.
ChemInform Abstract: Chemoselective Cross‐Coupling Reaction of Sodium Sulfinates with Phenols under Aqueous Conditions.
Authors: Xiao Fuhong , Chen Shuqing , Tian Jinxin , Huang Huawen , Liu Yuejin , Deng Guo‐Jun 
Published: July 2016

AbstractStable and readily available sodium sulfinates are used as the sulfur source.
ChemInform Abstract: Intermolecular C—N Cross‐Coupling Reactions Catalyzed by Tetra‐n‐butylammonium Iodide: Synthesis of Allylic N‐Heterocycles.
Authors: Lv Yunhe , Sun Kai , Wang Tingting , Wu Yingtao , Li Gang , Pu Weiya , Mao Shukuan 
Published: July 2016

AbstractAn operationally simple method for the oxidative coupling of cyclohexene to a variety of N‐heterocycles is demonstrated.
ChemInform Abstract: Spirocyclic Sultam and Heterobiaryl Synthesis Through Rh‐Catalyzed Cross‐Dehydrogenative Coupling of N‐Sulfonyl Ketimines and Thiophenes or Furans.
Authors: Mei Shu‐Tao , Liang Hong‐Wen , Teng Bin , Wang Nan‐Jin , Shuai Li , Yuan Yi , Chen Ying‐Chun , Wei Ye 
Published: July 2016

AbstractDepending on the thiophene or furan derivative used the scalable method provides either spirocyclic sultams or heterobiaryls.
ChemInform Abstract: Amination of 3‐Substituted Benzofuran‐2(3H)‐ones Triggered by Single‐Electron Transfer.
Authors: Yang Chen , Liu Yang , Yang Jin‐Dong , Li Yi‐He , Li Xin , Cheng Jin‐Pei 
Published: July 2016

AbstractVarious 3‐arylbenzofuran‐2(3H)ones are oxidatively aminated with dinitrobenzenesulfonic carbamates in moderate to high yields.
ChemInform Abstract: Transition‐Metal Free Thiocyanooxygenation of Functionalized Alkenes: Facile Routes to SCN‐Containing Dihydrofurans and Lactones.
Authors: Guo Li‐Na , Gu Yu‐Rui , Yang Hua , Hu Jie 
Published: July 2016

AbstractA tandem cyclization of olefins with thiocyanate salts under mild conditions affords the title compounds.
ChemInform Abstract: Fast Functionalization of (7‐Aza)indoles Using Continuous Flow Processes.
Authors: D'Attoma Joseph , Cozien Gregoire , Brun Pierre Louis , Robin Yves , Bostyn Stephane , Buron Frederic , Routier Sylvain 
Published: July 2016

AbstractThe functionalization of the title compounds proceeds in three steps, namely iodination, nitrogen protection, and copper‐free Sonogashira cross‐coupling reaction by using a continuous flow set‐up.
ChemInform Abstract: Silver Catalyzed Domino Aza‐Annulation/Diels—Alder Cyclization of 2‐Ene‐Yne Anilines: A Facile One‐Pot Access to Carbazole, Dihydrocarbazole and Tetrahydrocarbazole Frameworks.
Authors: Krishna Namballa Hari , Saraswati A Prasanth , Sathish Manda , Shankaraiah Nagula , Kamal Ahmed 
Published: July 2016

AbstractThe domino aza‐annulation/Diels—Alder cyclization of 2‐ene‐yne anilines (I) with acetylenedicarboxylate leads to desired carbazoles (III).
ChemInform Abstract: Cyclization of Alkyne—Azide with Isonitrile/CO via Self‐Relay Rhodium Catalysis.
Authors: Zhang Zhen , Xiao Fan , Huang Baoliang , Hu Jincheng , Fu Bin , Zhang Zhenhua 
Published: July 2016

AbstractPyrrolo[2,3‐b]indoles are synthesized using the title reaction via a tandem nitrene transformation and aza‐Pauson—Khand cyclization.
ChemInform Abstract: Amine Directed Pd(II)‐Catalyzed C—H Activation‐Intramolecular Amination of N‐Het(aryl)/Acyl Enaminonitriles and Enaminones: An Approach Towards Multisubstituted Indoles and Heterofused Pyrroles.
Authors: Yugandar Somaraju , Konda Saidulu , Ila Hiriyakkanavar 
Published: July 2016

AbstractThe reaction is characterized by high regioselectivity and functional group diversity.
ChemInform Abstract: One‐Pot Synthesis of Oxazolidine Derivatives by [3 + 2]‐Annulation Reactions of 1‐Tosyl‐2‐phenyl/alkylaziridines with Aryl Epoxides.
Authors: Pandey Ashok Kumar , Banerjee Prabal 
Published: July 2016

AbstractA BF3·OEt2‐promoted reaction of aziridines and aldehydes generated in situ from epoxides is developed to furnish various functionalized oxazolidines.
ChemInform Abstract: A Base Promoted Multigram Synthesis of Aminoisoxazoles: Valuable Building Blocks for Drug Discovery and Peptidomimetics.
Authors: Chalyk Bohdan A. , Kandaurova Inna Y. , Hrebeniuk Kateryna V. , Manoilenko Olga V. , Kulik Irene B. , Iminov Rustam T. , Kubyshkin Vladimir , Tverdokhlebov Anton V. , Ablialimov Osman K. , Mykhailiuk Pavel K. 
Published: July 2016

AbstractThe reactions are carried out under metal‐free conditions.
ChemInform Abstract: A Tandem Prins Spirocyclization for the Stereoselective Synthesis of Tetrahydrospiro[chroman‐2,4′‐pyran] Derivatives.
Authors: Subba Reddy B. V. , Hanuman Reddy V. , Medaboina Durgaprasad , Sridhar B. , Rami Reddy Y. V. 
Published: July 2016

AbstractSingle diastereomers of title compounds are obtained by the title reaction with aryl or cinnamyl aldehydes.
ChemInform Abstract: Tandem Arylation/Friedel—Crafts Reaction of O‐Hydroxy Bisbenzylic Alcohols with Diaryliodonium Salts: One Pot Synthesis of Unsymmetrical 9‐Arylxanthenes.
Authors: Mao Song , Hua Zerui , Wu Xunshen , Yang Yang , Han Jianwei , Wang Limin 
Published: July 2016

AbstractAn efficient one‐pot method for the reaction of o‐hydroxy bisbenzylic alcohols and diaryliodonium salts is presented.
ChemInform Abstract: A Convenient Route to Symmetrically and Unsymmetrically Substituted 3,5‐Diaryl‐2,4,6‐trimethylpyridines via Suzuki—Miyaura Cross‐Coupling Reaction.
Authors: Blachut Dariusz , Szawkalo Joanna , Czarnocki Zbigniew 
Published: July 2016

AbstractUnder optimized conditions, a series of title compounds (III) and (VI) are synthesized via cross‐coupling reaction.
ChemInform Abstract: Palladium‐Catalyzed Divergent Arylation with Triazolopyridines: One‐Pot Synthesis of 6‐Aryl‐2‐α‐styrylpyridines.
Authors: Moon Youngtaek , Kwon Soonhyung , Kang Dahye , Im Honggu , Hong Sungwoo 
Published: July 2016

AbstractThe title pyridines are successfully prepared by two different catalytic arylations performed in one‐pot with a single Pd catalyst using two different bases.
ChemInform Abstract: Organocatalytic One‐Pot Asymmetric Synthesis of 2‐Aryl‐2,3‐dihydro‐4‐quinolones.
Authors: Pan Gao‐Fei , Su Li , Zhang Yan‐Lei , Guo Shi‐Huan , Wang Yong‐Qiang 
Published: July 2016

AbstractThe reaction is conducted under environmentally benign conditions and gives the corresponding quinolines with up to 99% enantioselective excess.
ChemInform Abstract: Chiral Triazoles in Anion‐Binding Catalysis: New Entry to Enantioselective Reissert‐Type Reactions.
Authors: Zurro Mercedes , Asmus Soeren , Bamberger Julia , Beckendorf Stephan , Garcia Mancheno Olga 
Published: July 2016

AbstractThe Reissert‐type dearomatization of isoquinoline derivatives proceeds in high yields and moderate enantioselectivities.
ChemInform Abstract: Acid‐Catalyzed Multicomponent Tandem Cyclizations: Access to Polyfunctional Dihydroindolizino[8,7‐b]indoles.
Authors: Cai Qun , Li Deng‐Kui , Zhou Rong‐Rong , Shu Wen‐Ming , Wu Yan‐Dong , Wu An‐Xin 
Published: July 2016

AbstractSimple, readily available starting materials are used for the preparation of the desired alkaloid scaffold under metal‐free conditions A) or B).
ChemInform Abstract: Synthesis of Enantiopure Piperazines via Asymmetric Lithiation—Trapping of N‐Boc Piperazines: Unexpected Role of the Electrophile and Distal N‐Substituent.
Authors: Firth James D. , O'Brien Peter , Ferris Leigh 
Published: July 2016

AbstractYield and stereoselectivity in these reactions are controlled by the electrophile and the distal N‐substituent of piperazine.
ChemInform Abstract: The Synthesis of Multifunctionalized 1,3‐Oxazin‐4‐ones from Donor—Acceptor Cyclopropanes.
Authors: Smith Robert J. , Mills Daniel A. , Nhu Duong , Tan Eng Wui , Lucas Nigel T. , Hawkins Bill C. 
Published: July 2016

AbstractA reliable but low‐yielding protocol for preparation of oxazinones from simple, readily available starting material is presented.
ChemInform Abstract: Oxidative Functionalization of Styrenes: Synthesis of 1,3,5‐Triazines from Styrenes via Tandem Cyclization with Amidines.
Authors: Tiwari Abhishek R. , Bhanage Bhalchandra M. 
Published: July 2016

AbstractAn efficient method is presented for a transition metal and solvent‐free reaction of easily available styrenes with amidines leading to various triazines.
ChemInform Abstract: Gold(I)‐Catalyzed Inter‐ and Intramolecular Additions of Carbonyl Compounds to Allenenes.
Authors: Jimenez Tania , Carreras Javier , Ceccon Julien , Echavarren Antonio M. 
Published: July 2016

AbstractA series of allenenes bearing an additional 11‐oxo function is subjected to either conditions A) or B) containing a gold catalyst.
ChemInform Abstract: A Fluorination/Aryl Migration/Cyclization Cascade for the Metal‐Free Synthesis of Fluoro‐Benzoxazepines.
Authors: Ulmer Anna , Brunner Christoph , Arnold Andreas M. , Poethig Alexander , Gulder Tanja 
Published: July 2016

AbstractThe efficient, regioselective method is based on an operationally simple fluorination of readily available, structurally diverse styrene derivatives with a hypervalent iodine(III) fluoro reagent.
ChemInform Abstract: One‐Pot Suzuki Coupling of Aromatic Amines via Visible Light Photocatalyzed Metal Free Borylation Using t‐BuONO at Room Temperature.
Authors: Ahammed Sabir , Nandi Shiny , Kundu Debasish , Ranu Brindaban C. 
Published: July 2016

AbstractThis metal free borylation shows good functional group tolerance and provides aryl boronates in high yields.
ChemInform Abstract: Copper‐Catalyzed trans‐Hydroboration of Terminal Aryl Alkynes: Stereodivergent Synthesis of Alkenylboron Compounds.
Authors: Jang Won Jun , Lee Woo Lim , Moon Jong Hun , Lee Jin Yong , Yun Jaesook 
Published: July 2016

AbstractUsing 2 different catalyst combinations, either (Z)‐ oder (E)‐configurated title compounds are available.
ChemInform Abstract: Gold vs Rhodium Catalysis: Tuning Reactivity Through Catalyst Control in the C—H Alkynylation of Isoquinolones.
Authors: Shaikh Aslam C. , Shinde Dinesh R. , Patil Nitin T. 
Published: July 2016

AbstractConditions for the gold or rhodium catalyzed alkynylation of isoquinolones are developed allowing for the site‐selective C‐4 or C‐8 functionalization, respectively.
ChemInform Abstract: Rhodium(I)‐Catalyzed Highly Enantioselective Insertion of Carbenoid into Si—H: Efficient Access to Functional Chiral Silanes.
Authors: Chen Diao , Zhu Dong‐Xing , Xu Ming‐Hua 
Published: July 2016

Abstractα‐Silyl esters and phosphonates are prepared under mild reaction conditions and with excellent enantioselectivities starting from α‐diazoester and phosphonates, resp.
ChemInform Abstract: Substituent‐Controlled Chemoselective Cleavage of C=C or C(sp2)—C(CO) Bond in α,β‐Unsaturated Carbonyl Compounds with H‐Phosphonates Leading to β‐Ketophosphonates.
Authors: Zhou Yao , Rao Changqing , Mai Shaoyu , Song Qiuling 
Published: July 2016

Abstractβ‐Ketophosphonates are obtained via retro‐HWE reaction from α,β‐unsaturated carbonyl compounds and H‐phosphonates.
ChemInform Abstract: A Rapid One‐Pot Five Component Sequential Access to Novel Imidazo[2,1‐b]thiazinyl‐α‐aminophosphonates.
Authors: Kaur Tanpreet , Saha Debasmita , Singh Neetu , Singh Udai P. , Sharma Anuj 
Published: July 2016

AbstractThe two‐step sequential Groebke—Blackburn—Bienayme and Kabachnik—Fields reaction gives access to novel bisheterocyclic scaffolds through a microwave‐assisted one‐pot method.
ChemInform Abstract: Iridium‐Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (‐)‐Aspidophylline A.
Authors: Jiang Shi‐Zhi , Zeng Xue‐Yi , Liang Xiao , Lei Ting , Wei Kun , Yang Yu‐Rong 
Published: July 2016

AbstractA highly enantioselective indole allylic alkylation iminium cyclization cascade is developed and successfully applied as a key step in the total synthesis of (‐)‐aspidophylline A (VII).
ChemInform Abstract: A New Monoacylglycerol from the Fruiting Bodies of Gymnopilus spectabilis.
Authors: Suh Won Se , Lee Seoung Rak , Kim Chung Sub , Moon Eunjung , Kim Sun Yeou , Choi Sang Un , Kang Ki Sung , Lee Kang Ro , Kim Ki Hyun 
Published: July 2016

AbstractThe new monoacylglycerol (I) is isolated along with five known compounds.
ChemInform Abstract: Magnetic Mechanisms of Pairing in Strongly Correlated Electron System of Copper Oxides
Authors: Ovchinnikov S. G. , Makarov I. A. , Shneyder E. I. , Togushova Yu. N. , Gavrichkov V. A. , Korshunov M. M. 
Published: July 2016

AbstractReview: 241 refs.
Out of the forest: past and present range expansion of a parthenogenetic weevil pest, or how to colonize the world successfully
Authors: Rodriguero Marcela S. , Lanteri Analía A. , Guzmán Noelia V. , Carús Guedes Jerson V. , Confalonieri Viviana A. 
Published: July 2016

AbstractPrevious research revealed complex diversification patterns in the parthenogenetic weevil Naupactus cervinus. To understand the origin of clonal diversity and successful spreading of this weevil, we investigated its geographic origin and possible dispersal routes and whether parthenogens can persist in habitats under unsuitable environmental conditions. This study is based on samples taken throughout a broad area of the species’ range. We used both mitochondrial and nuclear markers and applied phylogenetic and network analyses to infer possible relationships between haplotypes. Bayesian phylogeographic analyses and ecological niche modeling were used to investigate the processes that shaped genetic diversity and enabled the colonization of new geographic areas. Southeastern Brazil emerges as the original distribution area of N. cervinus. We detected two range expansions, one along natural corridors during the Pleistocene and the other in countries outside South America during recent times. Isolation due to climate shifts during the early Pleistocene led to diversification in two divergent clades, which probably survived in different refugia of the Paranaense Forest and the Paraná River delta. The origin of the clonal diversity was probably a complex process including mutational diversification, hybridization, and secondary colonization. The establishment of N. cervinus in areas outside its native range may indicate adaptation to drier and cooler conditions. Parthenogenesis would be advantageous for the colonization of new environments by preventing the breakup of successful gene combinations. As in other insect pests, the present distribution of N. cervinus results from both its evolutionary history and its recent history related to human activities.
Knocking back invasions: variable resistance and resilience to multiple cold spells in native vs. nonnative fishes
Authors: Rehage J. S. , Blanchard J. R. , Boucek R. E. , Lorenz J. J. , Robinson M. 
Published: July 2016

AbstractExtreme climate events can interact synergistically with invasions to dramatically alter ecosystem structure, function, and services. Yet, the effects of extreme climate events on species invasions remain unresolved. Extreme climate events may increase resources and decrease biotic resistance by causing physiological stress and/or mortality of native taxa, resulting in invasion opportunities for nonnative species. Alternatively, extreme climate events may regulate nonnative populations, preventing them from achieving dominance. We examined whether a sequence of three cold spells had a negative or positive effect on fish invasions in the coastal Everglades. We compared resistance (initial effects) and resilience (rate of recovery) to the cold spells between native fishes and the dominant nonnative invader, the Mayan cichlid, across eight populations expanding two mangroves drainages in the southern Everglades. We tracked native fish and nonnative Mayan cichlid populations for 10 yr including 3 yr pre‐ and 4 yr post‐cold spells. In both drainages, native fishes were more resistant to the cold spells than the nonnative species. While native fishes experienced declines at only one site, nonnative Mayan numbers were reduced by 90–100% across six sites where they were abundant pre‐disturbances. Four years after the last cold spell, we saw limited resilience in the affected nonnative populations. Only one of the six affected sites fully recovered, whereas the other five sites showed no recovery in Mayan cichlid numbers. The recovered site was closest to a canal, known to act as thermal refuges for nonnative fishes. In summary, cold spells can reduce nonnative abundances, but whether cold spells can effectively knock back invasions (and range expansions) by tropical/subtropical nonnative species will depend on how the frequency and severity of cold spells are affected by climate change. We propose that these mortality‐causing extreme events could provide rare management opportunities late in an invasion.
Uncertainty in the net hydrologic flux of calcium in a paired‐watershed harvesting study
Authors: Campbell John L. , Yanai Ruth D. , Green Mark B. , Likens Gene E. , See Craig R. , Bailey Amey S. , Buso Donald C. , Yang Daqing 
Published: July 2016

AbstractMonitoring solutes in precipitation inputs and stream water exports at small watersheds has greatly advanced our understanding of biogeochemical cycling. Surprisingly, although inputs to and outputs from ecosystems are instrumental to understanding sources and sinks of nutrients and other elements, uncertainty in these fluxes is rarely reported in ecosystem budgets. We illustrate error propagation in input–output budgets by comparing the net hydrologic flux of Ca in a harvested and reference watershed at the Hubbard Brook Experimental Forest, New Hampshire. We identify sources of uncertainty and use a Monte Carlo approach to combine many sources of uncertainty to produce an estimate of overall uncertainty. Sources of uncertainty in precipitation inputs included in this study were: rain gage efficiency (undercatch or overcatch), gaps in measurements of precipitation volume, selection of a model for interpolating among rain gages, unusable precipitation chemistry, and chemical analysis. Sources of uncertainty in stream water outputs were: stage height–discharge relationship, watershed area, gaps in the stream flow record, chemical analysis, and the selection of a method for flux calculation. The annual net hydrologic flux of Ca in the harvested and reference watersheds was calculated from 1973 through 2009. Relative to the reference watershed, the harvested watershed showed a marked increase in Ca flux after it was cut in 1983–1984, and slowly declined toward pretreatment levels thereafter. In 2009, the last year evaluated, the 95% confidence intervals for the annual estimates approach the 95% confidence intervals of the pretreatment regression line, suggesting that the increased net loss of Ca in the harvested watershed may soon be indistinguishable from the reference. Identifying the greatest sources of uncertainty can be used to guide improvements, for example in reducing instances of unusable precipitation chemistry and gaps in stream runoff. Our results highlight the value of estimating uncertainty in watershed studies, including those in which replication is impractical.