bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical profiling and quantification of XueBiJing injection, a systematic quality control strategy using UHPLC-Q Exactive hybrid quadrupole-orbitrap high-resolution mass spectrometry
Authors: Sun Zhi , Zuo Lihua , Sun Tongwen , Tang Jinfa , Ding Daling , Zhou Lin , Kang Jian , Zhang Xiaojian 
Published: November 2017

AbstractTo clarify and quantify the chemical profiling of XueBiJing injection (XBJ) rapidly, a feasible and accurate strategy was developed by applying ultra high performance liquid chromatography-Q Exactive hybrid quadrupole-orbitrap high resolution accurate mass spectrometry (UHPLC-Q-Orbitrap HRMS). A total of 162 components were characterized, including 19 phenanthrenequinones, 33 lactones, 28 flavonoids and 12 phenolic acids and 51 other compounds. Among them, 38 major compounds were unambiguously quantified by comparing with reference standards. Meanwhile, 38 representative compounds were simultaneously detected in XBJ samples by Q-Orbitrap HRMS. Satisfactory linearity and correlation coefficient were achieved with wide linear range. The precisions, repeatability, stability and recovery were meeting requirements. The validated method was successfully applied for simultaneous determination of 38 bioactive compounds in 10 batches XBJ samples. In addition, the similarity evaluation of fingerprintings was applied to assess the quality of XBJ. And the results were evaluated by multiple statistical strategies and five compounds might be the most important chemical markers for chemical quality control of XBJ. Finally, a rapid and simple UPLC-MS/MS method was developed for determination of five markers in XBJ sample. This research established a high sensitive and efficient strategy for integrating quality control, including identification and quantification of XBJ.
Monitoring trifluridine incorporation in the peripheral blood mononuclear cells of colorectal cancer patients under trifluridine/tipiracil medication
Authors: Nakanishi Ryota , Kitao Hiroyuki , Kiniwa Mamoru , Morodomi Yosuke , Iimori Makoto , Kurashige Junji , Sugiyama Masahiko , Nakashima Yuichiro , Saeki Hiroshi , Oki Eiji , Maehara Yoshihiko 
Published: November 2017

AbstractTrifluridine/tipiracil (TFTD, TAS-102) is an orally administrated anti-cancer drug with efficacy validated for patients with metastatic colorectal cancer (mCRC). Trifluridine (FTD) is an active cytotoxic component of TFTD and mediates the anticancer effect via its incorporation into DNA. However, it has not been examined whether FTD is incorporated into the tissues of patients who received TFTD medication. By detecting FTD incorporation into DNA by a specific antibody, we successfully detected FTD in the bone marrow and spleen cells isolated from FTD-challenged mice as well as human peripheral blood mononuclear cells (PBMCs) activated with phytohemagglutinin-P and exposed to FTD in vitro. FTD was also detected in PBMCs isolated from mCRC patients who had administrated TFTD medication. Intriguingly, weekly evaluation of PBMCs from mCRC patients revealed the percentage of FTD-positive PBMCs increased and decreased in parallel with the administration and cessation of TFTD medication, respectively. To our knowledge, this is the first report to detect an active cytotoxic component of a chemotherapeutic drug in clinical specimens using a specific antibody. This technique may enable us to predict the clinical benefits or the adverse effects of TFTD in mCRC patients.
Technical Note on Using the Movement Velocity to Estimate the Relative Load in Resistance Exercises – Letter to the Editor
Authors: Naclerio Fernando , Larumbe-Zabala Eneko 
Published: November 2017

AbstractThe studies by Sanchez-Medina et al. (Sports Medicine International Open, 1(02), E80-E88. 2017) and Gonzalez-Badillo and Sanchez-Medina (Int J Sports Med, 31, 347–52. 2010) attempted to provide a good estimation of relative load from movement velocity measured in bench press and full squat. However, both aforementioned studies contain methodological issues concerning the predicted equations used to address load-velocity relationship that coaches should be aware of.
Messen statt raten
Authors: Seifert Jana-Maren 
Published: November 2017

SummaryDie Elektroakupunktur nach Voll ist eine nicht-invasive Messmethode, um das energetische Profil des Patienten zu erfassen und die Konstitution seines gesamten Organsystems aufzudecken. Sie bedient sich der Meridianlehre und elektrophysikalischer Messungen an bestimmten Akupunkturpunkten, im Wesentlichen der Hände und Füße. Das Verfahren zeichnet sich durch große diagnostische Vielseitigkeit aus, beispielsweise zur Erkennung von Allergenen, Störherden oder zur Austestung von Naturheilmitteln.
Ancient fish weir technology for modern stewardship: lessons from community-based salmon monitoring
Authors: Atlas William I. , Housty William G. , Béliveau Audrey , DeRoy Bryant , Callegari Grant , Reid Mike , Moore Jonathan W. 
Published: November 2017

ABSTRACT

Introduction:
The UN Declaration on the Rights of Indigenous Peoples states that indigenous people have a fundamental right to contribute to the management of the resources that support their livelihoods. Salmon are vital to the economy and culture of First Nations in coastal British Columbia, Canada. In this region, traditional systems of management including weirs – fences built across rivers to selectively harvest salmon – supported sustainable fisheries for millennia. In the late-19th century traditional fishing practices were banned as colonial governments consolidated control over salmon.

Outcomes:
In collaboration with the Heiltsuk First Nation we revived the practice of weir building in the Koeye River. Over the first four years of the project we tagged 1,226 sockeye, and counted 8,036 fish during fall stream walks. We used a mark-recapture model which accounted for both pre-spawn mortality due to variation in temperature, and tag loss, to produce the first mark-resight estimates of sockeye abundance in the watershed (4,600 – 15,000 escapement).

Discussion:
High river temperatures are associated with increased en route morality in migrating adult sockeye. We estimated pre-spawn mortality ranged from 8 – 72% across the four years of study, highlighting the degree to which climate conditions may dictate future viability in sockeye salmon populations. These results demonstrate the power of fusing traditional knowledge and management systems with contemporary scientific approaches in developing local monitoring.
Architectural membranes on building’s functional refurbishment
Authors: Macieira M , Mendonça P , Guedes J Miranda 
Published: November 2017

Abstract
The aim of this study is to make an insight about architectural membrane applications for building’s functional refurbishment, analysing the characteristics that make architectural membranes suitable for this purpose. It is based on sixty interventions used as case studies that are classified chronologically and by countries and uses, pointing out also their applications. Several design strategies are identified and contrasted with the principles set for interventions in existing buildings. The results are illustrated with examples chosen from the case studies, highlighting how membrane building technologies can fulfil the most important principles of building refurbishment.
Density of orbits of dominant regular self-maps of semiabelian varieties
Authors: Ghioca Dragos , Satriano Matthew 
Published: November 2017

We prove a conjecture of Medvedev and Scanlon [Ann. of Math. (2), 179 (2014), no. 1, 81–177] in the case of regular morphisms of semiabelian varieties. That is, if

G
G

is a semiabelian variety defined over an algebraically closed field

K
K

of characteristic

0
0

, and

φ
:
G
→
G

\varphi \colon G\to G

is a dominant regular self-map of

G
G

which is not necessarily a group homomorphism, we prove that one of the following holds: either there exists a nonconstant rational fibration preserved by

φ
\varphi

or there exists a point

x
∈
G
(
K
)

x\in G(K)

whose

φ
\varphi

-orbit is Zariski dense in

G
G

.
2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea
Authors: Shane Andi L , Mody Rajal K , Crump John A , Tarr Phillip I , Steiner Theodore S , Kotloff Karen , Langley Joanne M , Wanke Christine , Warren Cirle Alcantara , Cheng Allen C , Cantey Joseph , Pickering Larry K 
Published: November 2017

Abstract
These guidelines are intended for use by healthcare professionals who care for children and adults with suspected or confirmed infectious diarrhea. They are not intended to replace physician judgement regarding specific patients or clinical or public health situations. This document does not provide detailed recommendations on infection prevention and control aspects related to infectious diarrhea.
LGBTQ Populations and Social Work
Authors: Rosenwald Mitchell , Rodriguez Mabel M. 
Published: November 2017

It is well-documented that individuals who are lesbian, gay, bisexual, transgender, and queer/ questioning (LGBTQ) navigate their lives in the presence of stigma and discrimination. Social workers play an essential role as mentors, brokers, therapists, and advocates with individuals who are LGBTQ as they travel their life paths. This annotated bibliography intends to provide knowledge and practice applications to social workers and other professionals that will help increase their competencies with the LGBTQ population. Drawing on classic Texts, social workers can understand some of the historical and fundamental knowledge necessary to work with individuals who are LGBTQ. Specific knowledge of each subpopulation—Lesbians, Gay Men, Bisexual Individuals, and Transgender / Gender Nonconforming Individuals—is critical for understanding their experiences, challenges, and resiliencies. Furthermore, sexual orientation and gender identity variables intersect with other variables, such as race or ethnicity or both, ability status, Religious Affiliations, and age. These intersections shift and expand the LGBTQ lens toward an appreciation of the complexity of the human experience with multiple identity facets involved. For individuals who identify as LGBTQ, both oppression and resilience interplay in a range of areas. The decision to “come out,” the experience of historical and potentially psychological Trauma, the degree of social supports, Health and Mental Health status, and the potential involvement of child welfare systems are some of the issues and barriers many LGBTQ individuals experience and overcome. Yet others face difficulties rooted in heterosexism, homophobia, biphobia, and transphobia. Interventions at the clinical level can heal past and present traumas while interventions at the macro level can prevent some of the very trauma and distress the population faces. Social workers can avail themselves of key journal articles, texts, and references for the latest knowledge and advocacy efforts. Additionally, Organizations provide digital and in-person education, support, and advocacy for the LGBTQ population. Social workers serve on the frontlines and behind the scenes with their work with the LGBTQ population. They have an ethical imperative to work to provide support, healing, and advocacy. It our hope that the following bibliography is useful to social workers in this endeavor.
Multicenter Evaluation of a New Electrochemiluminescence Immunoassay for Everolimus Concentrations in Whole Blood
Authors: Verstraete Alain G. , Rigo-Bonnin Raül , Wallemacq Pierre , Vogeser Michael , Schuetzenmeister Andre , Schmiedel Christian , Shipkova Maria 
Published: November 2017

Background:
The precise monitoring of everolimus, an immunosuppressant drug, is vital for transplant recipients due to its narrow therapeutic range. This study evaluated the analytical performance of a new electrochemiluminescence immunoassay (ECLIA) for everolimus concentrations in whole blood.

Methods:
Accuracy, imprecision, and sensitivity studies for the Roche Elecsys everolimus ECLIA were performed at 5 European laboratories. The ECLIA was compared with liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods, as well as the Quantitative Microsphere System everolimus assay.

Results:
Everolimus ECLIA accuracies were within the range 100% ± 9%. Coefficients of variation (CVs) across the target range were ≤4.8% for repeatability and ≤8.4% for intermediate imprecision, whereas multisite reproducibility at lower (2.71 mcg/L) and higher everolimus concentrations (3.0–30.0 mcg/L) resulted in CVs of ≤13.7% and ≤12.4%, respectively. The CV at the assay's lower limit of quantification without considering bias was excellent, estimated as ≤9.3% at 0.5 mcg/L. The weighted Deming regression analysis, used for comparison of the results obtained by everolimus ECLIA and by LC-MS/MS methods, yielded a slope of 1.21 [95% confidence interval (CI): 1.15–1.26], intercept of 0.478 mcg/L (95% CI: 0.241–0.716), and a Pearson correlation coefficient (r) of 0.91. A single-site comparison between the ECLIA and the Quantitative Microsphere System assay revealed a slope of 1.05 (95% CI: 0.917–1.17), intercept of 1.03 mcg/L (95% CI: 0.351–1.70), and r of 0.91.

Conclusions:
Based on these results, the Roche Elecsys everolimus ECLIA can be considered suitable for routine therapeutic drug monitoring. A positive bias was observed with respect to LC-MS/MS methods, suggesting that it may be necessary to rebaseline individual patients when switching from LC-MS/MS to the ECLIA; however, this must also be considered for any change of method for everolimus measurement.
Preserving the Shoulder Function of an Elite Paratriathlete
Authors: Diaz Robert , Stoll Allison H. , Rho Monica E. , Blauwet Cheri A. 
Published: November 2017

Abstract
Shoulder pain in wheelchair users that participate in competitive adaptive sports can be a troublesome condition. Shoulder pain not only affects athletic performance but also affects functional activities such as wheelchair propulsion and weight bearing during transfers. Managing pain in these athletes thus presents a unique challenge because of the difficulty in achieving relative rest and the need to modify athletic shoulder-focused rehabilitation strategies. In all athletes, it is vital to establish an early, accurate diagnosis and optimize conservative treatment before considering surgical interventions to avoid excessive shoulder-related morbidity, loss of function, and, worse, loss of independence.
Urine RNA Processing in a Clinical Setting: Comparison of 3 Protocols
Authors: Bradley Megan S. , Boudreau Marie-Helene , Grenier Carole , Huang Zhiqing , Murphy Susan K. , Siddiqui Nazema Y. 
Published: November 2017

Objective
The objective of this study was to compare quantitative and qualitative RNA extraction results from clinical voided urine samples between 3 commercially available extraction protocols.

Methods
For phase 1, fresh voided urine samples from 10 female subjects were collected and processed in clinic and transported to the laboratory with cold packs. RNA was purified with 1 of 3 RNA extraction protocols: (1) TRI Reagent Protocol; (2) Absolutely RNA Nanoprep Kit; and (3) ZR Urine RNA Isolation Kit. Real-time polymerase chain reactions (RT-PCR) were performed. As the ZR Urine RNA Isolation Kit provided the highest quality RNA in phase 1, for phase 2, RNA was extracted from 9 additional voided urine specimens using this kit to perform additional qualitative analyses.

Results
Median RNA yield was significantly higher with the TRI Reagent Protocol as compared with the other protocols (P = 0.007). However, there was a significantly lower median threshold cycle value from polymerase chain reaction (indicating improved downstream application performance) with the ZR Urine RNA Isolation Kit as compared with the other methods (P = 0.005). In phase 2, the median RNA integrity number of urine RNA was 2.5 (range, 1.6–5.9).

Conclusions
Although other methods may provide a higher quantity of RNA, when using clinical urine samples, the ZR Urine RNA Isolation Kit provided the highest quality of extracted RNA. This kit is especially attractive for the clinical setting because it does not require an initial centrifugation step. The urine RNA obtained with this kit may be useful for polymerase chain reaction but is not likely to be of high enough integrity for RNA sequencing.
Short-term dosage regimen for stimulation-induced long-lasting desynchronization
Authors: Manos Thanos , Zeitler Magteld , Tass Peter A. 
Published: November 2017

AbstractIn this paper, we computationally generate hypotheses for dose-finding studies in the context of desynchronizing neuromodulation techniques. Abnormally strong neuronal synchronization is a hallmark of several brain disorders. Coordinated Reset (CR) stimulation is a spatio-temporally patterned stimulation technique that specifically aims at disrupting abnormal neuronal synchrony. In networks with spike-timing-dependent plasticity CR stimulation may ultimately cause an anti-kindling, i.e. an unlearning of abnormal synaptic connectivity and neuronal synchrony. This long-lasting desynchronization was theoretically predicted and verified in several pre-clinical and clinical studies. We have shown that CR stimulation with rapidly varying sequences (RVS) robustly induces an anti-kindling at low intensities e.g. if the CR stimulation frequency (i.e. stimulus pattern repetition rate) is in the range of the frequency of the neuronal oscillation. In contrast, CR stimulation with slowly varying sequences (SVS) turned out to induce an anti-kindling more strongly, but less robustly with respect to variations of the CR stimulation frequency. Motivated by clinical constraints and inspired by the spacing principle of learning theory, in this computational study we propose a short-term dosage regimen that enables a robust anti-kindling effect of both RVS and SVS CR stimulation, also for those parameter values where RVS and SVS CR stimulation previously turned out to be ineffective. Intriguingly, for the vast majority of parameter values tested, spaced multishot CR stimulation with demand-controlled variation of stimulation frequency and intensity caused a robust and pronounced anti-kindling. In contrast, spaced CR stimulation with fixed stimulation parameters as well as singleshot CR stimulation of equal integral duration failed to improve the stimulation outcome. In the model network under consideration, our short-term dosage regimen enables to robustly induce long-term desynchronization at comparably short stimulation duration and low integral stimulation duration. Currently, clinical proof of concept is available for deep brain CR stimulation for Parkinson’s therapy and acoustic CR stimulation for tinnitus therapy. Promising first in human data is available for vibrotactile CR stimulation for Parkinson’s treatment. For the clinical development of these treatments it is mandatory to perform dose-finding studies to reveal optimal stimulation parameters and dosage regimens. Our findings can straightforwardly be tested in human dose-finding studies.
Diminishing returns of inoculum size on the rate of a plant RNA virus evolution
Authors: Navarro Rebeca , Ambrós Silvia , Martínez Fernando , Elena Santiago F. 
Published: November 2017

AbstractUnderstanding how genetic drift, mutation and selection interplay in determining the evolutionary fate of populations is one of the central questions of Evolutionary Biology. Theory predicts that by increasing the number of coexisting beneficial alleles in a population beyond some point does not necessarily translates into an acceleration in the rate of evolution. This diminishing-returns effect of beneficial genetic variability in microbial asexual populations is known as clonal interference. Clonal interference has been shown to operate in experimental populations of animal RNA viruses replicating in cell cultures. Here we carried out experiments to test whether a similar diminishing-returns of population size on the rate of adaptation exists for a plant RNA virus infecting real multicellular hosts. We have performed evolution experiments with tobacco etch potyvirus in two hosts, the natural and a novel one, at different inoculation sizes and estimated the rates of evolution for two phenotypic fitness-related traits. Firstly, we found that evolution proceeds faster in the novel than in the original host. Secondly, we found the predicted diminishing-returns effect of inoculum size on the rate of evolution for one of the fitness traits, but not for the other, which suggests that selection operates differently on each trait.
The locations of innovation described through thirty-nine tech-campuses
Authors: Curvelo Magdaniel Flavia Teresa de Jesus , Den Heijer Alexandra C. , De Jonge Hans 
Published: November 2017

PurposeThis paper aims to describe the different locations of campuses developed to stimulate innovation. The paper aims at supporting strategic decisions in the development of new and existing campuses and similar innovation-driven areas. Additionally, it aims to outline the key role of location for urban and regional competitiveness in the knowledge economy.Design/methodology/approachThis paper tests an existing planning tool that proposes location and connectivity as key aspects to stimulate innovation in campus development. This tool is used to analyse and compare 39 campuses with different locations characteristics worldwide.FindingsFindings describe five types of location characteristics in existing campuses developed to stimulate innovation. These characteristics are dynamic, and exhibit differences in connectivity aspects enabling more or less efficient access to amenities and knowledge networks.Research limitations/implicationsEmpirical findings were used to revise and improve the planning tool. Further research exploring the relation between connectivity aspects and innovation processes is recommended.Practical implicationsThis paper supports decision-makers of new and existing campuses struggling with location decisions, by outlining that campus’ connectivity is crucial regardless of whether the campus is in an inner-city or a peripheral setting. Improving campus connectivity may be an efficient way to spend the many public and private resources invested on campus development to stimulate innovation.Originality/valueThis paper provides a unique comparison of cases that can be useful to planners of existing campuses to benchmark their current locations in relation to their ambitions on innovation.
Modelling small cell deployments within a macrocell
Authors: Webb William 
Published: November 2017

Purpose
Small cells, or microcells, are often seen as a way to substantially enhance the capacity of cellular networks. Previous assumptions have been that by deploying a dense layer of small cells within a macrocell, capacity can be improved by an order of magnitude or more. However, there are complexities such as the need to share frequencies between macrocell and small cells, varying patterns of users, the balance between indoor and outdoor subscribers and the different options available within 4G for balancing loading. The purpose of this study is to understand the impact these real-world constraints have on the capacity enhancements that small cells can provide.

Design/methodology/approach
This paper describes a model that simulates the impact of small cell deployments in macrocells in a typical 4G network.

Findings
It shows that, in some cases, small cells can actually reduce capacity, while in the best case, maximum capacity gains are less than 100 per cent.

Originality/value
It shows that, in some cases, small cells can actually reduce capacity contrary to perceived wisdom.