bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: PIPERAZINO‐FUNCTIONALIZED SILICA GEL AS A DEBLOCKING‐SCAVENGING AGENT FOR THE 9‐FLUORENYLMETHYLOXYCARBONYL AMINO‐PROTECTING GROUP
Authors: CARPINO L. A. , MANSOUR E. M. E. , KNAPCZYK J. 
Published: May 2016

Abstract3‐(′hlor‐propyl‐trimethoxysilan (I) reagiert mit Piperazin (III zu einem Substitutionsprodukt (III ), das an Kieselsäure zu (IV) fixiert werden kann.
ChemInform Abstract: A STEREOSELECTIVE SYNTHESIS OF 3‐ALKYL‐6‐METHOXY‐2,5‐PIPERAZINEDIONE DERIVATIVES
Authors: SHIN C.‐G. , YONEZAWA Y. , SATO Y. , NAKANO T. , YOSHIMURA J. 
Published: May 2016

AbstractDas durch Cyclisierung des Dipeptids (I) mit Chlorwasserstoff gebildete Piperazindion (II) wird nach Acetylierung mit den Aldehyden (IV) kondensiert.
ChemInform Abstract: Synthese von 11,20‐Dioxo‐4,7,l4,17‐tetrathia‐1,10‐bis(2‐carbomethoxyethy)‐1,10‐ diazacycloeicosan.
Authors: VORONKOV M. G. , KNUTOV V. I. , BUTIN M. K. 
Published: May 2016

AbstractDie Synthese der Titelverbindung (VII) wird beschrieben.
ChemInform Abstract: HYDROBORATION. 64. EFFECT OF STRUCTURE ON THE RELATIVE REACTIVITY OF REPRESENTATIVE ALKENES AND ALKYNES TOWARD HYDROBORATION BY DIBROMOBORANE‐METHYL SULFIDE
Authors: BROWN H. C. , CHANDRASEKHARAN J. 
Published: May 2016

AbstractDie Ergebnisse einer Reihenuntersuchung der relativen Reaktivitäten und Regioselektivitäten für die Hydroborierung von 22 Alkenen und 5 Alkinen mit (I) sind in einer ′l"abelle zusammengestellt.
ChemInform Abstract: FLUORIDE‐CATALYZED REACTION OF SILYLACETYLENES WITH CARBONYL COMPOUNDS
Authors: KUWAJIMA I. , NAKAMURA E. , HASHIMOTO K. 
Published: May 2016

AbstractDie Ketone (I) addieren Phenylethinyl‐trimethylsilan in Gegenwart von F′ unter Bildung der Silylether (II).
ChemInform Abstract: ORGANOFLUOROSILICATES IN ORGANIC SYNTHESIS. PART 17. OXIDATIVE CLEAVAGE OF SILICON‐CARBON BONDS IN ORGANOSILICON FLUORIDES TO ALCOHOLS
Authors: TAMAO K. , KAKUI T. , AKITA M. , IWAHARA T. , KANATANI R. , YOSHIDA J. , KUMADA M. 
Published: May 2016

Abstractm‐Chlor‐perbenzoesäure spaltet die Si‐C‐Bindungen von Alkylpentafluorosilicaten bzw. Organosiliciumfluoriden, 118 wie den Verbindungen (II), (IV), (VI) und (VIII), unter Bildung von Alkoholen, wobei die Reaktivität im Sinne (IV) (II) 2 (V I) (V IID abnimmt.
ChemInform Abstract: N‐PROPARGYLAMINOPHOSPHINES. A NEW REARRANGEMENT OF PROPARGYLHETEROATOM SUBSTITUTED TRIVALENT PHOSPHORUS COMPOUNDS
Authors: ANGELOV C. M. , DAHL O. 
Published: May 2016

AbstractAus den P‐(′hloriden (1) erhält man mit N‐Methyl‐propargylamin (II) in Gegenwart von Triethylamin die Kondensationsprodukte (111), die mit Schwefel zu den Sulfiden (IV) führen.
ChemInform Abstract: ADDITION OF AMINE NUCLEOPHILES TO DIPHOSPHORYLALKYNES. THE CHEMISTRY OF THE DERIVED ENAMINES
Authors: WHITESELL M. A. , KYBA E. P. 
Published: May 2016

AbstractAcetyIen‐I ,lbis‐phosphonsäureester (I) reagiert mit Aminen (II) zu Addukten (III) bzw. (IV) und (V).
ChemInform Abstract: 12H‐DIBENZO(D,G)(1,3,2)DIOXAPHOSPHOCINS: SYNTHESIS AND EVIDENCE FOR LONG‐RANGE COUPLING TO PHOSPHORUS
Authors: ODORISIO P. A. , PASTOR S. D. , SPIVACK J. D. , STEINHUEBEL L. , RODEBAUGH R. K. 
Published: May 2016

AbstractPCl3 cyclisiert die Hydroxydiphenylmethane (I) zu den Dibenzodioxaphosphocinen (II), die mit den Alkoholen (III) die Phosphite (IV) lie‐ "fern.
ChemInform Abstract: SYNTHESIS AND STRUCTURE OF AROMATIC AND HETEROCYCLIC TELLURIUM COMPOUNDS. XXII. NEW SYNTHESIS OF DIARYLTELLURIUM DICHLORIDES
Authors: SADEKOV I. D. , MAKSIMENKO A. A. , RIVKIN B. B. 
Published: May 2016

AbstractTeilweise in Anlehnung an Literaturverfahren, die weiterentwickelt werden,‐werden Synthesen der asymm. und der symm. Diaryltellurdihalogenide (III) sowie der asymm. Arylidenaryltellurdichloride (VI) angegeben, die auf der Umsetzung der Telluride (I) bzw. (V) mit den Aryldiazoniumverbindungen (II) in Gegenwart von Kupfersalzen beruhen.
ChemInform Abstract: SYNTHESIS, CHARACTERIZATION, AND CHEMISTRY OF PENTACARBONYLNITROSYLVANADIUM, V(CO)5NO, A REMARKABLY REACTIVE RELATIVE OF HEXACARBONYLCHROMIUM
Authors: FJARE K. L. , ELLIS J. E. 
Published: May 2016

AbstractDie Reaktion äquimolarer Mengen von (I) und (II) liefert (III), das flüchtig und thermisch instabil ist und bei ‐30 bis 0°C leicht mit einer Reihe von Lewis‐Basen unter Bildung der Komplexe (IV)‐(IX) reagiert.
ChemInform Abstract: Die Komplexbildung von Dehydro‐β‐ionon. Ein ungewöhnlicher Eisencarbonyl‐Komplex. Ein einfaches Verfahren zur Eliminierung der Liganden aus ihren Eisencarbonyl‐Komplexen.
Authors: FRANCK‐NEUMANN M. , HEITZ M. P. , MARTINA D. , DE CIAN A. 
Published: May 2016

Abstractβ‐Ionon (I) liefert die Eisen‐carbonyl‐Komplexe (II)‐(IV).
ChemInform Abstract: SYNTHESIS, MOLECULAR STRUCTURE AND CHEMISTRY OF P‐(COIII(TREN)(2‐(DIHYDROXYMETHYL)GLYCINATO))ZNCL4.2H2O
Authors: JACKSON W. G. , MCLAUGHLIN G. M. , SARGESON A. M. , WATSON A. D. 
Published: May 2016

AbstractDie Hydrolyse des früher aus dem entsprechenden Glycinato‐Komplex mit POCl3 /DMF erlangten Vilsmeier‐Adduktes (I) liefert den rac. Glycinaldehydkomplex, der im festen Zustand als (II) erhalten wird und in wäßriger Lösung als freier Aldehydkomplex (III) existiert.
ChemInform Abstract: METAL COMPLEXES WITH MACROCYCLIC LIGANDS. XVII. SYNTHESIS OF TWO KEY INTERMEDIATES FOR THE PREPARATION OF MONO‐N‐FUNCTIONALIZED TETRAAZAMACROCYCLES AND THEIR METAL COMPLEXES
Authors: HEDIGER M. , KADEN T. A. 
Published: May 2016

AbstractUnter Abwandlung einer bereits beschriebenen Cyclisierungsmethode wurden die Makrocyclen (IIIa) bzw. (VIa) dargestellt.
ChemInform Abstract: PHOTOCHEMISTRY OF MIXED‐METAL BIMETALLIC COMPLEXES CONTAINING PENTACYANOFERRATE(II) OR PENTAAMMINERUTHENIUM(II) METAL CENTERS. EVIDENCE FOR SOME INTRAMOLECULAR ENERGY‐TRANSFER REACTIONS
Authors: MOORE K. J. , LEE L. , FIGARD J. E. , GELROTH J. A. , STINSON A. J. , WOHLERS H. D. , PETERSEN J. D. 
Published: May 2016

AbstractBestrahlung der Komplexe (I), die hochgradig absorbierende Metall‐zu‐Ligandiadungsübertragungs‐Banden im sichtbaren Spektralbereich zeigen, führt im allgemeinen zur Spaltung der M′‐L‐ oder L‐Mz‐Bindung.
ChemInform Abstract: OPTICALLY ACTIVE C5‐SYNTHONS FOR THE SYNTHESIS OF NATURALLY OCCURRING TERPENES
Authors: DUMONT R. , PFANDER H. 
Published: May 2016

AbstractBeschrieben wird die Synthese des S‐konfigurierten tert. Alkohols (III) aus L‐Serin (I) und dessen weitere Überführung in die optisch aktiven Synthone (VIII)‐(Xl).
ChemInform Abstract: TOTAL SYNTHESIS OF (‐)‐α‐ACORADIENE AND (‐)‐α‐CEDRENE
Authors: SOLAS D. , WOLINSKY J. 
Published: May 2016

AbstractDas aus (I) erhaltene cis,cis,trans‐Puleganolid (II) wird nach Metallierung zu (IV) substituiert und dann über diskutierte Zwischenstufen in (‐)‐a‐Acoradien (VII) übergeführt.
ChemInform Abstract: PEPTIDE SYNTHESIS USING IMMOBILIZED ENZYMES. II. IMMOBILIZED TRYPSIN, THERMOLYSIN AND PAPAIN
Authors: KOENNECKE A. + , HAENSLER M. + , SCHELLENBERGER V. , JAKUBKE H.‐D. 
Published: May 2016

AbstractDurch Auftragen der Enzyme Trypsin, Thermolysin bzw. Papain auf die Trägermaterialien Kieselgel, Enzacryl AA bzw.‐ Enzacryl Al‐Iwerden die entsprechenden immobilisierten Enzymsysteme erhalten.
ChemInform Abstract: SYNTHESIS OF PROTECTED PEPTIDE SEGMENTS AND THEIR ASSEMBLY ON A POLYMER‐BOUND OXIME: APPLICATION TO THE SYNTHESIS OF A PEPTIDE MODEL FOR PLASMA APOLIPOPROTEIN A‐I
Authors: NAKAGAWA S. H. , KAISER E. T. 
Published: May 2016

AbstractPolymer fixierte Benzophenonderivate (I) werden in (′iegenwart von I)(′(.′ zu den Oligopeptiilen (III) bzw. (IV) kondensiert.
ChemInform Abstract: SYNTHESIS OF A TRIPROTECTED DL‐β‐CARBOXYASPARTIC ACID (ASA) DERIVATIVE SUITABLE FOR THE SYNTHESIS OF ASA‐CONTAINING PEPTIDES
Authors: RICH D. H. , DHAON M. K. 
Published: May 2016

AbstractDie Malonsäureester (Ia) und (Ib) reagieren über die entsprechenden Na‐Salze mit dem Chloraminosäurederivat (II) zu den Verbindungen (III); der tert.‐Butylester (IIIc) wird über das lmin (IV) hergestellt.
ChemInform Abstract: THE CRYSTAL STRUCTURE OF METHYL β‐ORCINOLCARBOXYLATE (METHYL 2,4‐DIHYDROXY‐3,6‐DIMETHYLBENZOATE)
Authors: BREHM L. , STOECKLI‐EVANS H. , TABACCHI R. , BUERGI H.‐B. + 
Published: May 2016

AbstractNach der Isolierung aus Evernia prunastic L. Ach.
ChemInform Abstract: SYNTHESIS OF STEREOISOMERIC PINANTHROMBOXANE DERIVATIVES AND EVALUATION OF THE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS
Authors: BOUNAMEAUX Y. , COFFEY J. W. , O'DONNELL M. , KLING K. , QUINN R. J. , SCHOENHOLZER P. + , SZENTE A. , TOBIAS L. D. , TSCHOPP T. , WELTON A. F. , FISCHLI A. 
Published: May 2016

AbstractAusgehend von (‐)‐Myrtenol (I) und dem Orthoester (II) werden über die Stufe des Esters (+)‐(III) die Carbonsäure (+)‐(IV) [ ‐+ Lacton (‐)‐(V)] bzw. das Lacton (‐)‐(VI) synthetisiert.
ChemInform Abstract: SYNTHESIS OF (Z,Z)‐11,13‐HEXADECADIENAL, A PRINCIPAL COMPONENT OF NAVEL ORANGEWORM (PAMYELOIS TRANSITELLA) PHEROMONE
Authors: BISHOP C. E. , MORROW G. W. 
Published: May 2016

AbstractEs wird ein kommerziell anwendbarer ′Syntheseweg für das (Z,Z)‐l l ,l 3‐Hexadecadienal (IX), das mit dem im Titel genannten Pheromon identisch ist, beschrieben.
Single‐Dose Pharmacokinetic Study of Tramadol Extended‐Release Tablets in Children and Adolescents
Authors: Vandenbossche Joris , Van Peer Achiel , Richards Henry 
Published: May 2016

AbstractCombined analyses from 2 open‐label, phase‐1 studies—the pharmacokinetic profile of tramadol and its metabolite (M1) following a single oral dose of tramadol extended release (ER) (25 to 100 mg) in children (7 to 11 years old; study 1: n = 37) and adolescents (12 to 17 years old; study 2: n = 38) with painful conditions—were historically compared with that of healthy adults following similar dosing. The dose‐normalized area under the curve (DN AUC0‐24h) and maximum concentration (DN Cmax) of tramadol and of M1 in children and in adolescents were lower than those in adults (children vs adults: tramadol, DN AUC0‐24h 82.19%; DN Cmax 80.38%, P = .0031; M1, DN AUC0‐24h 51.19%, DN Cmax 52.68%, P < .0001; adolescents vs adults: tramadol, DN AUC0‐24h 89.56%, DN Cmax 84.01%; M1, DN AUC0‐24h 85.28%, DN Cmax 83.03%, P = .0004). The arithmetic mean terminal elimination t1/2 of tramadol in children and adolescents was comparable to that in adults (children 8.4 hours; adolescents 8.5 hours; adults 7.9 hours). The most frequently reported (≥5% of participants) treatment‐emergent adverse events in children included headache, upper abdominal pain and constipation, and in adolescents were headache, nausea, dizziness, and stomach discomfort. Multiple factors may have contributed to these observations, including a higher proportion of children (56%) who may have a lower activity of CYP2D6, resulting in reduced clearance of tramadol.
Confirmation of Biosimilarity in a Pharmacokinetic/Pharmacodynamic Study in Healthy Volunteers for an Analytically Highly Similar Pegfilgrastim
Authors: Desai Kalpna , Catalano Tina , Rai Gurinder , Misra Priya , Shah Nirmesh 
Published: May 2016

AbstractA phase 1 pharmacokinetic (PK) and pharmacodynamic (PD) study was conducted to demonstrate similarity of a proposed pegfilgrastim biosimilar to its reference product. In a single‐dose, randomized, assessor‐blinded, 2‐way crossover, active‐controlled PK/PD study, 66 healthy adults received the proposed pegfilgrastim biosimilar and US‐licensed pegfilgrastim reference product. Primary end points were pegfilgrastim AUCt and Cmax (PK), and absolute neutrophil count AUECt and Emax (PD). Safety and immunogenicity were also measured. Fifty‐six subjects completed both arms of the study. Mean pegfilgrastim concentration–time profile for both products was similar, with the 90% confidence intervals (CI) of the relative mean ratio for the primary end points falling within the predefined acceptance criteria of 80%–125% (91.7%–116.1% and 86.7%–110.2% for AUCt and Cmax, respectively). PD similarity was also demonstrated by the 95%CI of the relative mean ratio of the primary end point parameters within the predefined acceptance margins of 80%–125% (96.0%–101.6% and 92.6%–100.1% for AUECt and Emax, respectively). No statistically meaningful PK/PD differences were observed. No clinically meaningful safety or immunological differences were observed with the proposed pegfilgrastim biosimilar that were not previously identified with the reference product. The proposed pegfilgrastim biosimilar product is highly similar to the reference product with regard to PK/PD.
Facile Uptake and Release of Ammonia by Nickel Halide Ammines
Authors: Breternitz Joachim , Vilk Yury E. , Giraud Elsa , Reardon Hazel , Hoang Tuan K. A. , Godula‐Jopek Agata , Gregory Duncan H. 
Published: May 2016

AbstractAlthough major difficulties are experienced for hydrogen‐ storage materials to meet performance requirements for mobile applications, alternative fuel cell feedstocks such as ammonia can be stored in the solid state safely at high capacity. We herein describe the NiX2‐NH3 (X=Cl, Br, I) systems and demonstrate their exceptional suitability for NH3 storage (up to 43 wt % NH3 with desorption that begins at 400 K). The structural effects that result from the uptake of NH3 were studied by powder X‐ray diffraction (PXD), FTIR spectroscopy and SEM. NH3 release at elevated temperatures was followed by in situ PXD. The cycling capabilities and air stability of the systems were also explored. NH3 is released from the hexaammines in a three‐step process to yield the diammine, monoammine and NiX2 dihalides respectively and (re)ammoniation occurs readily at room temperature. The hexaammines do not react with air after several hours of exposure.
Nonrandom filtering effect on birds: species and guilds response to urbanization
Authors: Silva Carmen Paz , Sepúlveda Roger D. , Barbosa Olga 
Published: May 2016

AbstractUsing bird survey data taken in three cities in Southern Chile, we evaluated the hypothesis that changes in community composition from periurban to urban areas are not random. Furthermore, the consistency of species and guild loss was assessed across cities. A consistent pattern of difference in community and guild structure between urban and periurban habitats was found. In addition, a nonrandom loss of species was found in urban areas compared to periurban areas, and non‐native species dominated urban communities in all cities. The average abundance of omnivores, granivores, and habitat generalists was higher in urban areas, while insectivores and open habitat species were more abundant in periurban areas. These results strongly suggest that urban habitats act as filters offering suitable conditions for only a fraction of the bird species present in a given area, and the lack of suitable conditions may be facilitating local biotic homogenization in the three studied cities. The results of this study not only fill a biogeographical knowledge gap, but the work presented here also aids the general understanding of factors that affect community structure in habitats with varied levels of local and global urbanization.
A study on fire behaviour of combustible components of two commonly used photovoltaic panels
Authors: Chow C. L. , Han S. S. , Ni X. M. 
Published: May 2016

SummaryPhotovoltaic (PV) modules are installed in some modern buildings for generating renewable energy. When a building catches fire, burning PV panels can contribute to an already very hazardous environment. Two common polycrystalline silicon PV samples A and B were selected with their chemical composition analysed by the Fourier transform infrared spectroscopy with justification by X‐ray photoelectron spectroscopy results. Sample A was confirmed to be a silicate product with polyurethane adhesive, and sample B has epoxy resin and is likely to have flame retardant as claimed. Thermal analysis by heating the samples was carried out using thermogravimetric analysis and thermogravimetric analysis coupled with infrared spectroscopy. The fire behaviour was then studied by a cone calorimeter under radiative heat fluxes from 10 to 70 kWm−2. Three key parameters representing flashover propensity, total heat release per unit area and smoke toxicity hazard were obtained from the cone calorimeter tests for ranking the thermal and smoke hazards. The thermal hazards of both PV samples are low, at least during the early stage of a fire without flame acting directly on the sample. However, vast quantities of smoke were emitted from burning PV panels under high heat fluxes. Copyright © 2016 John Wiley & Sons, Ltd.
A higher resolution edge‐based finite volume method for the simulation of the oil–water displacement in heterogeneous and anisotropic porous media using a modified IMPES method
Authors: da Silva Rogério Soares , Lyra Paulo Roberto Maciel , Willmersdorf Ramiro Brito , de Carvalho Darlan Karlo Elisiário 
Published: May 2016

SummaryIn this article, we present a higher‐order finite volume method with a ‘Modified Implicit Pressure Explicit Saturation’ (MIMPES) formulation to model the 2D incompressible and immiscible two‐phase flow of oil and water in heterogeneous and anisotropic porous media. We used a median‐dual vertex‐centered finite volume method with an edge‐based data structure to discretize both, the elliptic pressure and the hyperbolic saturation equations. In the classical IMPES approach, first, the pressure equation is solved implicitly from an initial saturation distribution; then, the velocity field is computed explicitly from the pressure field, and finally, the saturation equation is solved explicitly. This saturation field is then used to re‐compute the pressure field, and the process follows until the end of the simulation is reached. Because of the explicit solution of the saturation equation, severe time restrictions are imposed on the simulation. In order to circumvent this problem, an edge‐based implementation of the MIMPES method of Hurtado and co‐workers was developed. In the MIMPES approach, the pressure equation is solved, and the velocity field is computed less frequently than the saturation field, using the fact that, usually, the velocity field varies slowly throughout the simulation. The solution of the pressure equation is performed using a modification of Crumpton's two‐step approach, which was designed to handle material discontinuity properly. The saturation equation is solved explicitly using an edge‐based implementation of a modified second‐order monotonic upstream scheme for conservation laws type method. Some examples are presented in order to validate the proposed formulation. Our results match quite well with others found in literature. Copyright © 2016 John Wiley & Sons, Ltd.
In the Wake of the Great
Authors: Grube Nikolai , Delvendahl Kai 
Published: May 2016

AbstractWhen the Maya city of Uxul, a small kingdom in the rainforest, came under the rule of the powerful Kaan dynasty, it was the beginning of a blossoming that was later followed by their joint downfall. A team of German and Mexican archaeologists are excavating new evidence of this story of political power and the history of a city.
Discharge‐sediment processes of the Zhadang glacier on the Tibetan Plateau measured with a high frequency data acquisition system
Authors: Chen Fei , Cai Qiangguo , Sun Liying , Lei Tingwu 
Published: May 2016

AbstractIn high elevation cold regions of the Tibetan Plateau, suspended sediment transfer from glacier meltwater erosion is one of the important hydrological components. The Zhadang glacier is a typical valley‐type glacier in the Nyainqentanglha Mountains on the Tibetan Plateau. To make frequent and long period records of meltwater runoff and sediment processes in the very high elevation and isolated regions, an automatic system was installed near the glacier snout (5400 m a.s.l) in August 2013, to measure the transient discharge and sediment processes at 5‐min interval, which is shorter than the time span for the water flow to traverse the catchment from the farthest end to the watershed outlet. Diurnal variations of discharge, and suspended sediment concentration (SSC) were recorded at high frequency for the Zhadang glacier, before suspended sediment load (SSL) was computed. Hourly SSC varied from the range of 0.2 kg/m3to 0.5 kg/m3(at 8:00–9:00) to the range of 2.0 kg/m3to 4.0 kg/m3(at 17:00–18:00). The daily SSL was 32.24 t during the intense ablation period. Hourly SSC was linearly correlated with discharge (r = 0.885**,n = 18,p < 0.01). A digit‐eight hysteresis loop was observed for the sediment transport in the glacier area. Air temperature fluctuations influence discharge, and then result in the sediment variations. The results of this study provide insight into the responses of suspended sediment delivery processes with a high frequency data in the high elevation cold regions. Copyright © 2016 John Wiley & Sons, Ltd.
Nϵ‐Carboxymethyllysine Increases the Expression of miR‐103/143 and Enhances Lipid Accumulation in 3T3‐L1 Cells
Authors: Holik Ann‐Katrin , Lieder Barbara , Kretschy Nicole , Somoza Mark M. , Held Sandra , Somoza Veronika 
Published: May 2016

ABSTRACTAdvanced glycation endproducts, formed in vivo, but also by the Maillard reaction upon thermal treatment of foods, have been associated with the progression of pathological conditions such as diabetes mellitus. In addition to the accumulation with age, exogenous AGEs are introduced into the circulation from dietary sources. In this study, we investigated the effects of addition of free Nϵ‐carboxymethyllysine (CML), a well‐characterized product of the Maillard reaction, on adipogenesis in 3T3‐L1 preadipocytes. Treatment with 5, 50, or 500 μM CML resulted in increased lipid accumulation to similar extents, by 11.5 ± 12.6%, 12.9 ± 8.6%, and 12.8 ± 8.5%, respectively. Long‐term treatment with 500 μM CML during adipogenesis resulted in increases in miR‐103 and miR‐143 levels, two miRNAs described to be involved in impaired glucose homeostasis and increased lipid accumulation. Furthermore, the expression of genes associated with these miRNAs, consisting of Akt1, PI3k, and Cav1 was regulated by CML. Short‐term treatment of mature 3T3‐L1 adipocytes with CML resulted in decreased basal glucose uptake. These results, indicate that the addition of protein‐free CML to 3T3‐L1 cells influence parameters associated with adipogenesis and glucose homeostasis at transcriptional, and functional level; this indicates that free CML derived from exogenous sources, in addition to protein‐bound CML may be relevant in this context. J. Cell. Biochem. 117: 2413–2422, 2016. © 2016 The Authors. Journal of Cellular Biochemistry Published by Wiley Periodicals, Inc.