bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphatidic acid is involved in regulation of autophagy in neurons in vitro and in vivo
Authors: Schiller Maximilian , Wilson Gregory C. , Keitsch Simone , Soddemann Matthias , Wilker Barbara , Edwards Michael J. , Scherbaum Norbert , Gulbins Erich 
Published: October 2024

AbstractMajor depressive disorder (MDD) is a common and severe psychiatric disease, which does not only lead to variety of neuropsychiatric symptoms, but unfortunately in a relatively large proportion of cases also to suicide. The pathogenesis of MDD still requires definition. We have previously shown that ceramide is increased in the blood plasma of patients with MDD. In mouse models of MDD, which are induced by treatment with corticosterone or application of chronic unpredictable stress, increased blood plasma ceramide also increased and caused an inhibition of phospholipase D in endothelial cells of the hippocampus and reduced phosphatidic acid levels in the hippocampus. Here, we demonstrated that corticosterone treatment of PC12 cells resulted in reduced cellular autophagy, which is corrected by treatment with phosphatidic acid. In vivo, treatment of mice with corticosterone or chronic unpredictable stress also reduced autophagy in hippocampus neurons. Autophagy was normalized upon i.v. injection of phosphatidic acid in these mouse models of MDD. In an attempt to identify targets of phosphatidic acid in neurons, we demonstrated that corticosterone reduced levels of the ganglioside GM1 in PC-12 cells and the hippocampus of mice, which were normalized by treatment of cells or i.v. injection of mice with phosphatidic acid. GM1 application also normalized autophagy in cultured neurons. Phosphatidic acid and GM1 corrected stress-induced alterations in behavior, i.e., mainly anxiety and anhedonia, in experimental MDD in mice. Our data suggest that phosphatidic acid may regulate via GM1 autophagy in neurons.
Unified non-hourglass formulation for total Lagrangian SPH solid dynamics
Authors: Wu Dong , Tang Xiaojing , Zhang Shuaihao , Hu Xiangyu 
Published: October 2024

Abstract
The persistence of hourglass modes poses a significant numerical instability issue in total Lagrangian smoothed particle hydrodynamics (TLSPH) solid dynamics, especially when dealing with substantial deformations, regardless of material properties. However, existing hourglass control methods have shown effectiveness only within limited applications. Thus far, a comprehensive solution capable of addressing hourglass issues across a wide range of material models, including elasticity, plasticity, and anisotropy, remains elusive. In this study, we introduce a unified TLSPH formulation grounded in volumetric-deviatoric stress decomposition, aimed at fundamentally mitigating hourglass modes in general simulations. Different conceptually from previous approaches using stress points or extra viscous or hourglass-control stresses within the momentum equation, our formulation is based on the weighted average of a standard but hourglass-prone formulation and an essentially non-hourglass formulation for elastic materials, employing a single limiter to dynamically adjust the weighting between the two formulations. Crucially, the dimensionless characteristic of the formulation enables seamless handling of complex material models. To validate the effectiveness of our formulation, we conduct simulations across a range of benchmark cases involving elastic, plastic, and anisotropic materials. To illustrate its versatility, we apply the formulation to simulate a complex scenario involving viscous plastic Oobleck material, contacts, and very large deformation. Our work addresses a critical gap in TLSPH simulations by offering a unified approach to mitigate hourglass modes, enhancing the reliability and accuracy of simulations across diverse material models and complex scenarios.
Posttreatment health interventions for adult cancer survivors and their families: an integrated review
Authors: Coyne Elisabeth , Dieperink Karin B. , Voltelen Barbara , da Silva Barreto Mayckel , Garcia-Vivar Cristina 
Published: October 2024

Abstract
Purpose
This review aimed to synthesize the literature regarding health interventions delivered to adult cancer survivors and their families during posttreatment phase.

Methods
An integrative literature review was conducted that included quantitative and qualitative studies. The search was carried out in four databases using the same terms or MeSH terms and included data from January 2012 to February 2024. After quality assessment, data were extracted and synthesized. The protocol was registered in PROSPERO.

Results
Among the seven studies included, two studies were randomized controlled trials, three were observational, and two utilized a qualitative approach. The studies originated from France, Australia, Canada, the UK, and the USA. In total, 704 participants were included, 294 were cancer survivors, 40 were non-cancer patients, 271 were family and caregivers, and 99 were healthcare professionals. The studies assessed survival durations after cancer treatment, ranging from 18 months to 6 years. The sparse interventions found across the studies used a multifaceted approach tailored to address various aspects of cancer survivorship and caregiver support.

Conclusion
This review provides insights into the complex landscape of posttreatment support requirements for cancer survivors and their family caregivers. This finding underscores the critical necessity for additional intervention research involving comprehensive, accessible, and supportive services that address the multifaceted dimensions of survivorship for the patient and family as a unit.
„Zunächst wegen eines persönlichen Motivs“ – Über das psychoanalytische Arbeiten im Sitzen
Authors: Datz-Schwab Felicitas 
Published: October 2024

ZusammenfassungDie psychoanalytische Arbeit ist eng mit dem Liegen auf einer Behandlungscouch assoziiert. Dies zeigt sich nicht nur in Fachkreisen, sondern wird auch in medialen und popkulturellen Darstellungen der Psychoanalyse deutlich. Das eingereichte Manuskript stellt, ausgehend von Freuds Schrift zur Einleitung der Behandlung, die Frage, welche persönlichen Motive die Etablierung dieses Settings neben den besser bekannten und mehr beachteten technischen Überlegungen begleiten könnten. Dies erscheint lohnenswert, da die Arbeit im Liegen im Vergleich zur Arbeit im Sitzen als „psychoanalytischer“ betrachtet zu werden scheint. Diskutiert werden zu diesem Zweck teils unbewusste Vorstellungen eines Ich-Ideals, von dem psychoanalytische Therapeut:innen geleitet sein können. Ausgehend von Theorien zu Ich-Ideal und Beschämung nimmt das vorliegende Essay eine hemmende Angst auf Seiten der Behandler:in an, bei Nicht-Entsprechung dieses Ideals aus der eigenen Gruppe in das Nicht-Psychoanalytisch-Sein verstoßen zu werden. Dementsprechend ergibt sich die Auffassung, dass die therapeutische Arbeit im Sitzen die Analytiker:in vor spezifische Herausforderungen stellt, welche insbesondere den inneren Rahmen der Behandler:in fordern und die Notwendigkeit der selbstanalytischen Fertigkeiten unterstreichen.
Partizipative Arbeit in der Früherkennung
Authors: Berger Maximus E. , Hinterbuchinger Barbara , Mossaheb Nilufar 
Published: October 2024

ZusammenfassungDie partizipative Beteiligung von Menschen mit psychischen Erkrankungen gehört zu den wichtigsten Voraussetzungen für personenzentrierte und menschenrechtsorientierte Versorgung und Forschung in der Psychiatrie. Diese Entwicklung spiegelt ein breiteres Verständnis für die Notwendigkeit wider, Forschung nicht nur für, sondern mit betroffenen Personen durchzuführen. Während international eine deutliche Zunahme an der Entwicklung von partizipativen Ansätzen in Forschung und Patient:innenversorgung zu beobachten ist, ist eine flächendeckende Umsetzung bislang weit von der Realität entfernt.Dieser Artikel stellt einen Überblick über Modelle und Prinzipien partizipativer Forschung im Bereich der Früherkennung und Frühintervention von Psychosen vor. Vorteile von partizipativen Ansätzen und Barrieren werden diskutiert und die Umsetzung anhand zweier Fallbeispiele illustriert.
Probabilistic model for high-level intention estimation and trajectory prediction in urban environments
Authors: Bok Yunsoo , Suganuma Naoki , Yoneda Keisuke 
Published: October 2024

AbstractTo enable successful automated driving, precise behavior prediction of surrounding vehicles is indispensable in urban traffic scenarios. Furthermore, given that a vehicle’s behavior is influenced by the movements of other road users, it becomes crucial to estimate their intentions to anticipate precise future motion. However, the elevated complexity resulting from interdependencies among traffic participants and the uncertainty arising from the object recognition errors present additional challenges. Despite extensive research on inferring intentions, many studies have concentrated on estimating intentions from interactions, resulting in a lack of practicality in urban traffic environments due to low computational efficiency and low robustness against recognition failure of strongly interacting road users. In this paper, we introduce a practical stochastic model for intention estimation and trajectory prediction of surrounding vehicles in automated driving under urban traffic environments. The trajectory is forecasted based on hierarchically computed and probabilistically estimated intentions, which represent an interpretation of vehicle behavior, utilizing only the kinematic state of the focal vehicle and HD maps to ensure real-time performance and enhance robustness. The evaluated results demonstrate that the proposed model surpasses straightforward methods in terms of accuracy while maintaining computational efficiency and exhibits robustness against the recognition failure of traffic participants which strongly influence the focal vehicle.
Employment Effects of Skills Trainings in Sub-Saharan Africa: A Systematic Review of Recent Randomized Controlled Trials
Authors: Beber Bernd , Lakemann Tabea , Schnars Regina , Lay Jann 
Published: October 2024

Abstract
This study provides a comprehensive systematic review of recent randomized controlled trials (RCTs) to evaluate the employment effects of skills training programs in sub-Saharan Africa. The review focuses on studies conducted between 2019 and 2024, a period marked by a significant increase in the number of RCTs of training interventions in this region, and we thus fill a gap left by earlier reviews that did not reflect this recent surge in experimental studies. We employ the standard SPIDER approach for defining search terms and the PRISMA procedure for search and selection to systematically analyze the impact of these training programs on employment outcomes. The findings reveal a shift towards a more optimistic assessment compared to previous analyses, suggesting that many recent skills training programs do contribute to improving employment-related outcomes.
Ralstonia solanacearum (phylotype II) isolated from Rosa spp. in the Netherlands is closely related to phylotype II isolates from other sources in the Netherlands and is virulent on potato
Authors: Blom Nathalie I. , Gorkink-Smits Peggy P.M.A. , Landman N. Marco , van de Bilt Jeroen L.J. , Vogelaar Martijn A.W. , Raaymakers Tom M. , Visser Michael , Pel Michiel J.C. , Bergsma-Vlami Maria 
Published: October 2024

Abstract
In 2018, during an annual survey in the Netherlands, Ralstonia solanacearum phylotype II (phy II) was found in asymptomatic greenhouse rose plants at three geographic locations. These findings were remarkable, since previous findings of Ralstonia sp. in rose always concerned Ralstonia pseudosolanacearum phylotype I (phy I). Therefore, no information was available on the virulence of R. solanacearum phy II on rose. In this study, R. solanacearum phy II isolates PD 7421 and PD 7394, isolated in 2018 from asymptomatic ornamental rose (Rosa spp.), were assessed for their virulence in two rose cultivars (“Armando” and “Red Naomi”) at two temperatures. No typical symptoms were observed for PD 7421 and PD 7394 on the two rose cultivars, irrespective of the temperature. However, latent infections upon inoculation of these isolates on rose did occur. R. solanacearum phy II is known as a major potato pathogen, where it causes brown rot. Whole genome multilocus sequence typing analysis demonstrated that the isolates from rose were closely related to R. solanacearum phy II isolates previously found in seed potato and surface water in the Netherlands. Because of this close genetic relatedness, the virulence of PD 7421 and PD 7394 was also assessed in potato plants, where both isolates caused severe disease symptoms on the shoots as well as the daughter tubers. This implies that rose can act as a reservoir for R. solanacearum phy II and, in this way, can potentially be involved in spreading this bacterium.
Cracking the Code: Hidden Choices and Visible Impacts Pattern Recognition in Corporate Finance
Authors: Ali Amjad , Oad Rajput Suresh Kumar 
Published: October 2024

AbstractResearch in corporate finance suffers from bounded rationality due to static modeling. Adopting factor analysis, an unsupervised machine learning approach, and balance sheet information (accounts) over time, we find underlying dynamic latent corporate finance decisions. Our study identifies three latent corporate finance decisions adopted by executives in Pakistan, (1) long-term capital investment, (2) short-term debt credit, and (3) financial flexibility. The order of the decisions and the empirical tests highlight agency problems rooted in familial ownership concentration. We find that long-term capital investment and short-term debt credit decisions significantly reduce the firms’ present and future performance. Conversely, managers do not embrace financial flexibility, despite its ability to improve performance. The study highlights a contradiction, firms bounded by ownership concentration prefer control over performance and do not make decisions to optimize and protect minority shareholders’ wealth, depicting a moral hazard problem.
Preventing Overrides of Severe Drug Allergy Alerts Initiative: an Implemented System Upgrade
Authors: Abu Esba Laila Carolina , Al Moaiseib Samar , BinSabbar Norah Saud , Al Mardawi Ghada Hussain Salamah , Alkatheri Mufareh , Al Dekhail Saleh 
Published: October 2024

Abstract
Administering medications to patients with documented drug hypersensitivity reactions (DHR) poses a significant risk for adverse events, ranging from mild reactions to life-threatening incidents. Electronic healthcare systems have revolutionized the modern clinical decision-making process, with built in warnings. However, as these alerts become a routine part of healthcare provider’s workflow, alert fatigue becomes a challenge. This study was conducted within the Ministry of National Guard Health Affairs (MNGHA), a government healthcare system in Saudi Arabia. A taskforce of experts was formed to develop an electronic path that would prevent unintentional overrides of severe drug allergy alerts. The system underwent rigorous testing, and monitoring parameters were established. We outline the implementation of a system upgrade designed to trigger an alternative interruption in the computerized physician order entry (CPOE) process, distinct from the regular allergy pop-up alerts. The alternate path is activated upon a CPOE with a drug-to-drug match and a documented severe drug allergy symptom, necessitating co-signature form another prescriber before proceeding. The adopted upgrade is a proactive approach to enhance medication safety in electronic healthcare systems, ensuring that serious allergy-related warnings are not overridden, ultimately enhancing patient safety. Further monitoring will confirm the safety and effectiveness of this measure. This study provides a model for institutions seeking to prevent allergy-related harm within their patient population.
More digitalization does not always imply more technology transfer: an analysis within the horizon Europe strategy
Authors: Ferrer-Serrano Marta , Fuentelsaz Lucio , Gil-Lamata Mercedes 
Published: October 2024

AbstractDigitalization plays a pivotal role in today’s economies, facilitating global collaboration by overcoming geographical barriers and enabling technology exchange. Conventional wisdom holds that digitalization directly impacts technology transfer (TT). However, this relationship is not always straightforward. This research challenges this assumption by arguing that countries with higher levels of digitalization may be less effective in TT activities than countries with intermediate digital performance. Drawing on data from Horizon Europe and the Digital Economy and Society Index, the study conducts a two-stage analysis (first a network analysis, followed by a clustering and ANOVA) covering 411 collaborative projects in 31 countries, involving 2,890 participating organizations. Our findings confirm that countries with intermediate levels of digitalization emerge as leaders within the TT network. Furthermore, the study sheds light on specific digitalization indicators (connectivity, human capital, and the integration of digital technology) that can improve the position of European countries within the network.
Anomalous release of indoles from amorphous solid dispersion formed with a polymeric network
Authors: Bulátkó Anna , Domján Attila , Balterer Bence , Madarász János , László Krisztina 
Published: October 2024

Abstract
Amorphous solid dispersion (ASDs) is a technique used in the pharmaceutical industry to enhance the solubility, dissolution rate, and bioavailability of poorly soluble drugs. Polymeric materials, and recently polymer gels form and stabilize the amorphous structure by inhibiting the aggregation/precipitation of such drugs. In this work indole, 5-aminoindole and 5-hydroxyindole loaded poly (N-isopropylacrylamide) (PNIPA) hydrogels were studied. Swelling and uptake measurements, X-ray diffraction (XRD), liquid and solid phase nuclear magnetic spectroscopy (NMR) and high sensitivity differential scanning calorimetry (DSC) were applied to understand the drug – matrix interactions affecting the release. We confirmed that the hydrogel fostered the fine uniform distribution of the hydrophobic probe molecules and successfully prevented any crystalline or amorphous phase formation during water removal, leading to a glassy solution, a special form of ASD. Despite the limited difference between their chemical composition the probe molecules showed dissimilar drug release behavior from dried loaded gel disks. While Nuclear Overhauser Enhancement Spectroscopy (NOESY) measurements revealed a “bidental” interaction between 5-hydroxiindole and the polymer, no localized interactions were found for indole. The release of the bidentally linked derivatives is rapid and complete: they act as molecular spacers, promoting the rehydration of the chains. In contrast, part of the indole remains irreversibly trapped being confined between the chains without any orientation, shedding light on the role of the steric consequences of the interaction. Our findings also indicate that such drug delivery compositions should be treated as ternary systems (carrier + drug + liquid) already in the design stages of drug release systems.
Thermodynamic–kinetic calculations and dilatometric verification of the martensitic and bainitic transformations in 4% medium-Mn steel
Authors: Skowronek Adam , Kozłowska Aleksandra 
Published: October 2024

AbstractThe present study investigated the theoretical and experimental phase transitions phenomena during continuous cooling and isothermal holding above and below Ms temperature in 4 mass. % Mn medium-Mn steel. The thermodynamic–kinetic calculations were performed using JMatPro software, and phase transformations were recorded using a BÄHR high-resolution DIL805A/D dilatometer. The research covered continuous cooling rates from 60 to 0.05 °C s–1 and isothermal holding temperatures in a range between 420 °C and 230 °C. The issues related to both modelling and dilatometric methodology were discussed. The CCT and TTT diagrams were prepared on the basis of dilatometry and compared with the results of light microscopy and hardness tests. The alloy containing about 4 mass.% Mn and 0.22% Mo exhibited very high hardenability as only continuous cooling with rates lower than 1 °C s–1 allowed the bainitic transformation to be initiated. The bainitic transformation is accelerated after passing the Ms temperature. Both the incubation time and the time needed to complete the transformation were significantly reduced (the incubation time from 100 s to below 1 s and the completion time from over 4000 s to below 1000 s). The obtained microstructures were homogeneous and refined.
Socio-demographic disparities in the familiarity with coastal climate adaptation strategies: implications for coastal management and climate justice
Authors: Wang Haoluan 
Published: October 2024

Abstract
Public preferences for coastal climate adaptation strategies have been increasingly documented in the face of climate change and sea-level rise in coastal regions worldwide. However, empirical evidence of whether the public is familiar with these strategies remains unclear. In this study, we conducted an online survey among residents in three coastal counties in Southeast Florida, the United States to elicit households’ familiarity with different coastal climate adaptation strategies and examine the socio-demographic disparities. Using a multinomial logit model, we find that although most respondents are familiar with coastal climate adaptation strategies, socio-demographic disparities in the level of familiarity are evident. Specifically, Black respondents are significantly less likely to be familiar with coastal climate adaptation strategies when compared to their White counterparts. Moreover, having college degrees or more advanced degrees significantly increases the respondents’ probability of being very familiar with these strategies. Respondents’ risk perception and their awareness of current flood risk also significantly influence their familiarity with coastal climate adaptation strategies. Since adaptive planning often overlooks equitable access, and local support is essential for implementing climate adaptation strategies, our results can provide insightful policy implications for coastal management. A lack of familiarity with coastal climate adaptation strategies among marginalized and vulnerable populations can lead to insufficient support for these strategies aimed at mitigating climate risks, exacerbating the issue of climate justice.
Explaining Protest Participation in Semi-authoritarian Regimes: The Power of Social Networks
Authors: Kopacheva Elizaveta 
Published: October 2024

AbstractThis study uses the case of ecological protests in the Russian Federation and the social network of 903 263 VKontakte users to investigate the unique characteristics of protesters’ social networks and assess the effects of network topology on the likelihood of participation. By applying Bayesian structural equation modeling to the data, the study finds that social network topology plays a more nuanced and complex role in predicting protest participation beyond simple exposure to information. Notably, individuals situated as brokers in lower-density and higher-closure networks exhibit a higher likelihood of participation, while central nodes participate less. The results highlight the importance of strategic positioning as brokers for increasing the likelihood of participation. The paper discusses these and other findings, contributing to a deeper understanding of the interplay between social network structures and protest participation.