bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prophylactic stretching does not reduce cramp susceptibility
Authors: Miller Kevin C. , Harsen James D. , Long Blaine C. 
Published: August 2017

ABSTRACTIntroduction: Some clinicians advocate stretching to prevent muscle cramps. It is unknown whether static or proprioceptive neuromuscular facilitation (PNF) stretching increases cramp threshold frequency (TFc), a quantitative measure of cramp susceptibility. Methods: Fifteen individuals completed this randomized, counterbalanced, cross‐over study. We measured passive hallux range of motion (ROM) and then performed 3 minutes of either static stretching, PNF stretching (hold–relax—with agonist contraction), or no stretching. ROM was reassessed and TFc was measured. Results: PNF stretching increased hallux extension (pre‐PNF 81 ± 11°, post‐PNF 90 ± 10°; P < 0.05) but not hallux flexion (pre‐PNF 40 ± 7°, post‐PNF 40 ± 7°; P > 0.05). Static stretching increased hallux extension (pre‐static 80 ± 11°, post‐static 88 ± 9°; P < 0.05) but not hallux flexion (pre‐static 38 ± 9°, post‐static 39 ± 8°; P > 0.05). No ROM changes occurred with no stretching (P > 0.05). TFc was unaffected by stretching (no stretching 18 ± 7 Hz, PNF 16 ± 4 Hz, static 16 ± 5 Hz; P = 0.37). Discussion: Static and PNF stretching increased hallux extension, but neither increased TFc. Acute stretching may not prevent muscle cramping. Muscle Nerve 57: 473–477, 2018
The Nature, Development, and Effects of Elementary Students’ Reading Motivation Profiles
Authors: Schiefele Ulrich , Löweke Sebastian 
Published: August 2017

AbstractThe present study employed a longitudinal person‐centered approach to examine the profiles of reading motivation in a sample of 405 elementary school students who were tested in grades 3 and 4. Two dimensions of intrinsic reading motivation (involvement and curiosity) and two dimensions of extrinsic reading motivation (recognition and competition) were considered. Latent profile analyses revealed the same set of four profiles across third and fourth grades: high intrinsic (i.e., high on involvement and curiosity, low on recognition and competition), high involvement (i.e., high on involvement, low on the remaining dimensions), high quantity (high on all dimensions), and moderate quantity (low to moderate on all dimensions). Further results showed that 35% of the students changed their profile membership from third to fourth grade. We particularly observed an increased probability of students in the high‐quantity, moderate‐quantity, and high‐involvement profiles to move to the high‐intrinsic profile. Finally, the moderate‐quantity profile proved to be significantly lower in reading amount than the other groups that did not differ significantly. Pertaining to reading comprehension, however, the two intrinsic profiles outperformed both the high‐ and moderate‐quantity groups. The latter finding emphasizes the particular importance of intrinsic reading motivation.
Satellite remote sensing of ecosystem functions: opportunities, challenges and way forward
Authors: Pettorelli Nathalie , Schulte to Bühne Henrike , Tulloch Ayesha , Dubois Grégoire , Macinnis‐Ng Cate , Queirós Ana M. , Keith David A. , Wegmann Martin , Schrodt Franziska , Stellmes Marion , Sonnenschein Ruth , Geller Gary N. , Roy Shovonlal , Somers Ben , Murray Nicholas , Bland Lucie , Geijzendorffer Ilse , Kerr Jeremy T. , Broszeit Stefanie , Leitão Pedro J. , Duncan Clare , El Serafy Ghada , He Kate S. , Blanchard Julia L. , Lucas Richard , Mairota Paola , Webb Thomas J. , Nicholson Emily 
Published: August 2017

AbstractSocietal, economic and scientific interests in knowing where biodiversity is, how it is faring and what can be done to efficiently mitigate further biodiversity loss and the associated loss of ecosystem services are at an all‐time high. So far, however, biodiversity monitoring has primarily focused on structural and compositional features of ecosystems despite growing evidence that ecosystem functions are key to elucidating the mechanisms through which biological diversity generates services to humanity. This monitoring gap can be traced to the current lack of consensus on what exactly ecosystem functions are and how to track them at scales beyond the site level. This contribution aims to advance the development of a global biodiversity monitoring strategy by proposing the adoption of a set of definitions and a typology for ecosystem functions, and reviewing current opportunities and potential limitations for satellite remote sensing technology to support the monitoring of ecosystem functions worldwide. By clearly defining ecosystem processes, functions and services and their interrelationships, we provide a framework to improve communication between ecologists, land and marine managers, remote sensing specialists and policy makers, thereby addressing a major barrier in the field.
Numerical and experimental investigation of oblique shock wave reflection off a water wedge
Authors: Wan Q. , Jeon H. , Deiterding R. , Eliasson V. 
Published: August 2017

Shock wave interaction with solid wedges has been an area of much research in past decades, but so far very few results have been obtained for shock wave reflection off liquid wedges. In this study, numerical simulations are performed using the inviscid Euler equations and the stiffened gas equation of state to study the transition angles, reflection patterns and triple point trajectory angles of shock reflection off solid and water wedges. Experiments using an inclined shock tube are also performed and schlieren photography results are compared to simulations. Results show that the transition angles for the water wedge cases are within 5.3 % and 9.2 %, for simulations and experiments respectively, compared to results obtained with the theoretical detachment criterion for solid surfaces. Triple point trajectory angles are measured and compared with analytic solutions, agreement within $1.3^{\circ }$ is shown for the water wedge cases. The transmitted wave in the water observed in the simulation is quantitatively studied, and two different scenarios are found. For low incident shock Mach numbers, $M_{s}=1.2$ and 2, no shock wave is formed in the water but a precursor wave is induced ahead of the incident shock wave and passes the information from the water back into the air. For high incident shock Mach numbers, $M_{s}=3$ and 4, precursor waves no longer appear but instead a shock wave is formed in the water and attached to the Mach stem at every instant. The temperature field in the water is measured in the simulation. For strong incident shock waves, e.g. $M_{s}=4$, the temperature increment in the water is up to 7.3 K.
Spatial aggregation in small spring-fed tributaries leads to a potential metapopulation structure in a parasitic fish leech
Authors: KATAHIRA HIROTAKA , YAMAZAKI CHITOSE , FUKUI SHO , AYER CHRISTOPHER G. , KOIZUMI ITSURO 
Published: August 2017

SUMMARY
Large-bodied ectoparasites are often observed only in low numbers in the field. How such rarely found parasites persist and maintain viable populations has been an intriguing question inadequately addressed. The simplest hypothesis is the existence of distribution hot spots, and another, but not mutually exclusive, possibility is a form of metapopulation structure where local populations are effectively connected via dispersal. In this study, we conducted an intensive epidemiological survey of a piscicolid leech Taimenobdella amurensis to elucidate spatial population structure and potential dispersal of this rarely found parasite. Four years of potential-host screening (n = 20 664) from 28 tributaries and 10 main stem reaches in a mountain river system of Hokkaido, northern Japan, revealed that occurrences of T. amurensis (n = 1348) were confined to spring-fed tributaries. Since most spring-fed tributaries were small (&lt;1 km in length), it would seem to be unlikely for the ectoparasite to form a persistent local population in each tributary. The main host fish was Dolly Varden charr, which is known to disperse among neighbouring tributaries. These findings suggest that, along with the host, the ectoparasite displays a potential metapopulation structure, in which host-dependent dispersion may overcome local extinction by keeping the local populations connected.
A High-Resolution Foreground Model for the MWA EoR1 Field: Model and Implications for EoR Power Spectrum Analysis
Authors: Procopio P. , Wayth R. B. , Line J. , Trott C. M. , Intema H. T. , Mitchell D. A. , Pindor B. , Riding J. , Tingay S. J. , Bell M. E. , Callingham J. R. , Dwarakanath K. S. , For Bi-Qing , Gaensler B. M. , Hancock P. J. , Hindson L. , Hurley-Walker N. , Johnston-Hollitt M. , Kapińska A. D. , Lenc E. , McKinley B. , Morgan J. , Offringa A. , Staveley-Smith L. , Wu Chen , Zheng Q. 
Published: August 2017

AbstractThe current generation of experiments aiming to detect the neutral hydrogen signal from the Epoch of Reionisation (EoR) is likely to be limited by systematic effects associated with removing foreground sources from target fields. In this paper, we develop a model for the compact foreground sources in one of the target fields of the MWA’s EoR key science experiment: the ‘EoR1’ field. The model is based on both the MWA’s GLEAM survey and GMRT 150 MHz data from the TGSS survey, the latter providing higher angular resolution and better astrometric accuracy for compact sources than is available from the MWA alone. The model contains 5 049 sources, some of which have complicated morphology in MWA data, Fornax A being the most complex. The higher resolution data show that 13% of sources that appear point-like to the MWA have complicated morphology such as double and quad structure, with a typical separation of 33 arcsec. We derive an analytic expression for the error introduced into the EoR two-dimensional power spectrum due to peeling close double sources as single point sources and show that for the measured source properties, the error in the power spectrum is confined to highk⊥modes that do not affect the overall result for the large-scale cosmological signal of interest. The brightest 10 mis-modelled sources in the field contribute 90% of the power bias in the data, suggesting that it is most critical to improve the models of the brightest sources. With this hybrid model, we reprocess data from the EoR1 field and show a maximum of 8% improved calibration accuracy and a factor of two reduction in residual power ink-space from peeling these sources. Implications for future EoR experiments including the SKA are discussed in relation to the improvements obtained.
The ‘Perfect Person’ conception of God, versus the traditional conception: is the difference so great?
Authors: ROBINSON HOWARD 
Published: August 2017

AbstractVarious contemporary philosophers, with Richard Swinburne prominent amongst them, have abandoned the traditional philosophical conception of God, according to which He is absolutely simple and eternal (as opposed to sempiternal). These contemporary philosophers conceive of Him as a ‘perfect person’, immaterial, but with human-type virtues in a superhuman degree. I argue that, whilst this development is probably mistaken, nevertheless the traditionalist critics perhaps sometimes exaggerate the differences between these conceptions – except on the crucial issue of God's eternity.
Editorial: 29th International conference on logic programming special issue – ADDENDUM
Authors: LAMMA EVELINA , SWIFT TERRANCE 
Published: August 2017

The links to the online only Technical Communications in Lamma and Swift (2013) are unfortunately broken. All of the Technical Communications can be found here:https://www.cambridge.org/core/journals/theory-and-practice-of-logic-programming/article/editorial-29th-international-conference-on-logic-programming-special-issue/82FDD81073DC30A563ED242516CADAAE#fndtn-supplementary-materials
p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure
Authors: Huang Chih-Yang , Pai Pei-Ying , Kuo Chia-Hua , Ho Tsung-Jung , Lin Jing-Ying , Lin Ding-Yu , Tsai Fu-Jen , Padma V Vijaya , Kuo Wei-Wen , Huang Chih-Yang 
Published: August 2017

AbstractHypertension-induced cardiac hypertrophy and attenuated cardiac function are the major characteristics of early stage heart failure. Cardiomyocyte death in pathological cardiac conditions is the primary cause of heart failure and mortality. Our previous studies found that heat shock factor 1 (HSF1) protected cardiomyocytes from death by suppressing the IGF-IIR signaling pathway, which is critical for hypertensive angiotensin II-induced cardiomyocyte apoptosis. However, the role of heat shock factor 2 (HSF2) in hypertension-induced cardiac hypertrophy is unknown. We identified HSF2 as a miR-18 target for cardiac hypertrophy. p53 activation in angiotensin II (ANG II)-stimulated NRVMs is responsible for miR-18 downregulation both in vitro and in vivo, which triggers HSF2 expression and the activation of IGF-IIR-induced cardiomyocyte hypertrophy. Finally, we provide genetic evidence that miR-18 is required for cardiomyocyte functions in the heart based on the gene transfer of cardiac-specific miR-18 via adenovirus-associated virus 2 (AAV2). Transgenic overexpression of miR-18 in cardiomyocytes is sufficient to protect against dilated cardiomyopathy during hypertension-induced heart failure. Our results demonstrated that the p53-miR-18-HSF2-IGF-IIR axis was a critical regulatory pathway of cardiomyocyte hypertrophy in vitro and in vivo, suggesting that miR-18 could be a therapeutic target for the control of cardiac functions and the alleviation of cardiomyopathy during hypertension-induced heart failure.
LncRNA OIP5-AS1 loss-induced microRNA-410 accumulation regulates cell proliferation and apoptosis by targeting KLF10 via activating PTEN/PI3K/AKT pathway in multiple myeloma
Authors: Yang Nan , Chen Jinqiu , Zhang Hui , Wang Xiaman , Yao Huan , Peng Yue , Zhang Wanggang 
Published: August 2017

AbstractNumerous studies confirmed that aberrant miRNAs expression contributes to multiple myeloma (MM) development and progression. However, the roles of specific miRNAs in MM remain to be investigated. In present study, we demonstrated that miR-410 expression was increased in MM newly diagnosed and relapsed tissues and cell lines. Clinical analysis revealed that miR-410 was positively correlated with advanced ISS stage. Moreover, high miR-410 expression in MM patients showed an obvious shorter overall survival and progression-free survival. Gain- and loss-of function experiments indicated that miR-410 promoted cell proliferation, cell cycle progression and apoptosis inhibition both in vitro and in vivo. Moreover, KLF10 was identified as a direct downstream target of miR-410 in MM cells, and mediated the functional influence of miR-410 in MM, resulting in PTEN/AKT activation. In clinical samples of MM, miR-410 inversely correlated with KLF10. Alteration of KLF10 expression or AKT inhibitor at least partially abolished the biological effects of miR-410 on MM cells. Furthermore, downregulated expression of lncRNA OIP5-AS1 was inversely correlated with miR-410 expression in MM tissues. LncRNA OIP5-AS1 could modulate the miR-410 expression and regulate its target KLF10/PTEN/AKT-mediated cellular behaviors. Taken together, this research supports the first evidence that lncRNA OIP5-AS1 loss-induced miR-410 accumulation facilitates cell proliferation, cycle progression and apoptosis inhibition by targeting KLF10 via activating PTEN/PI3K/AKT pathway in MM.
Identification and characterization of a new source of adult human neural progenitors
Authors: Behnan Jinan , Stangeland Biljana , Langella Tiziana , Finocchiaro Gaetano , Tringali Giovanni , Meling Torstein R , Murrell Wayne 
Published: August 2017

AbstractAdult neural progenitor cells (aNPCs) are a potential source for cell based therapy for neurodegenerative diseases and traumatic brain injuries. These cells have been traditionally isolated from hippocampus, subventricular zone and white matter. However, there is still a need for an easily accessible source with better yield to counter the limitations of small surgical samples of previously characterized aNPCs. Here we show that ultrasonic aspirate (UA) samples currently considered as ‘biological waste after surgery,' offer a good source for aNPCs. Furthermore, we show that culture conditions dictated the phenotype of cells across patients. The neurosphere-enriched cells were more similar to freshly isolated brain cells, while cells expanded adherently in serum conditions were similar to mesenchymal stem cells. However, cells expanded in these adherent conditions expressed some NPC and glial markers in addition to active canonical Wnt signaling. This suggests a mesenchymal-neuroectodermal hybrid nature of these cells. Finally, we show that UA-NPCs are comparable to those from neurogenic regions. Our findings suggest that UA samples can be used as a source for fresh and in vitro propagated aNPCs that could have various clinical applications.
Rho inhibition by lovastatin affects apoptosis and DSB repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation
Authors: Ziegler Verena , Henninger Christian , Simiantonakis Ioannis , Buchholzer Marcel , Ahmadian Mohammad Reza , Budach Wilfried , Fritz Gerhard 
Published: August 2017

AbstractThoracic radiotherapy causes damage of normal lung tissue, which limits the cumulative radiation dose and, hence, confines the anticancer efficacy of radiotherapy and impacts the quality of life of tumor patients. Ras-homologous (Rho) small GTPases regulate multiple stress responses and cell death. Therefore, we investigated whether pharmacological targeting of Rho signaling by the HMG-CoA-reductase inhibitor lovastatin influences ionizing radiation (IR)-induced toxicity in primary human lung fibroblasts, lung epithelial and lung microvascular endothelial cells in vitro and subchronic mouse lung tissue damage following hypo-fractionated irradiation (4x4 Gy). The statin improved the repair of radiation-induced DNA double-strand breaks (DSBs) in all cell types and, moreover, protected lung endothelial cells from IR-induced caspase-dependent apoptosis, likely involving p53-regulated mechanisms. Under the in vivo situation, treatment with lovastatin or the Rac1-specific small molecule inhibitor EHT1864 attenuated the IR-induced increase in breathing frequency and reduced the percentage of γH2AX and 53BP1-positive cells. This indicates that inhibition of Rac1 signaling lowers IR-induced residual DNA damage by promoting DNA repair. Moreover, lovastatin and EHT1864 protected lung tissue from IR-triggered apoptosis and mitigated the IR-stimulated increase in regenerative proliferation. Our data document beneficial anti-apoptotic and genoprotective effects of pharmacological targeting of Rho signaling following hypo-fractionated irradiation of lung cells in vitro and in vivo. Rac1-targeting drugs might be particular useful for supportive care in radiation oncology and, moreover, applicable to improve the anticancer efficacy of radiotherapy by widening the therapeutic window of thoracic radiation exposure.
TNF signaling and macrophages govern fin regeneration in zebrafish larvae
Authors: Nguyen-Chi Mai , Laplace-Builhé Béryl , Travnickova Jana , Luz-Crawford Patricia , Tejedor Gautier , Lutfalla Georges , Kissa Karima , Jorgensen Christian , Djouad Farida 
Published: August 2017

AbstractMacrophages are essential for appendage regeneration after amputation in regenerative species. The molecular mechanisms through which macrophages orchestrate blastema formation and regeneration are still unclear. Here, we use the genetically tractable and transparent zebrafish larvae to study the functions of polarized macrophage subsets during caudal fin regeneration. After caudal fin amputation, we show an early and transient accumulation of pro-inflammatory macrophages concomitant with the accumulation of non-inflammatory macrophages which, in contrast to pro-inflammatory macrophages, remain associated to the fin until the end of the regeneration. Chemical and genetic depletion of macrophages suggested that early recruited macrophages that express TNFα are critical for blastema formation. Combining parabiosis and morpholino knockdown strategies, we show that TNFα/TNFR1 signaling pathway is required for the fin regeneration. Our study reveals that TNFR1 has a necessary and direct role in blastema cell activation suggesting that macrophage subset balance provides the accurate TNFα signal to prime regeneration in zebrafish.
Exogenous H2S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy
Authors: Wu Jichao , Tian Zhiliang , Sun Yu , Lu Cuicui , Liu Ning , Gao Zhaopeng , Zhang Linxue , Dong Shiyun , Yang Fan , Zhong Xin , Xu Changqing , Lu Fanghao , Zhang Weihua 
Published: August 2017

AbstractDiabetic cardiomyopathy (DCM) is a serious complication of diabetes. Hydrogen sulphide (H2S), a newly found gaseous signalling molecule, has an important role in many regulatory functions. The purpose of this study is to investigate the effects of exogenous H2S on autophagy and its possible mechanism in DCM induced by type II diabetes (T2DCM). In this study, we found that sodium hydrosulphide (NaHS) attenuated the augment in left ventricular (LV) mass and increased LV volume, decreased reactive oxygen species (ROS) production and ameliorated H2S production in the hearts of db/db mice. NaHS facilitated autophagosome content degradation, reduced the expression of P62 (a known substrate of autophagy) and increased the expression of microtubule-associated protein 1 light chain 3 II. It also increased the expression of autophagy-related protein 7 (ATG7) and Beclin1 in db/db mouse hearts. NaHS increased the expression of Kelch-like ECH-associated protein 1 (Keap-1) and reduced the ubiquitylation level in the hearts of db/db mice. 1,4-Dithiothreitol, an inhibitor of disulphide bonds, increased the ubiquitylation level of Keap-1, suppressed the expression of Keap-1 and abolished the effects of NaHS on ubiquitin aggregate clearance and ROS production in H9C2 cells treated with high glucose and palmitate. Overall, we concluded that exogenous H2S promoted ubiquitin aggregate clearance via autophagy, which might exert its antioxidative effect in db/db mouse myocardia. Moreover, exogenous H2S increased Keap-1 expression by suppressing its ubiquitylation, which might have an important role in ubiquitin aggregate clearance via autophagy. Our findings provide new insight into the mechanisms responsible for the antioxidative effects of H2S in the context of T2DCM.