bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corneal Infections—Challenges in Diagnosis and Update on Management
Authors: Jeng Bennie H ,   Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland, US
Published: April 2017

Bennie H Jeng is Professor and Chair of the Department of Ophthalmology and Visual Sciences at the University of Maryland School of Medicine. He earned his bachelor’s degree summa cum laude from Washington University and his MD from the University of Pennsylvania School of Medicine. He then completed his ophthalmology residency and chief residency at the Cole Eye Institute of the Cleveland Clinic, which was followed by a fellowship in cornea and external diseases at the Francis I. Proctor Foundation/University of California San Francisco (UCSF) in 2003. He then returned back to the Cole Eye Institute to serve on faculty, during which time he was the recipient of a K-grant from the NIH and also earned his Master degree in Clinical Investigation. He subsequently returned to Proctor/UCSF as an Associate Professor and then Full Professor, where he served as co-director of the UCSF cornea service, Director of the Proctor/UCSF Cornea Fellowship program, and as Chief of Ophthalmology at the San Francisco General Hospital. He was an R01-funded researcher at UCSF, and he assumed his current position at the University of Maryland in August, 2013.
Dr Jeng is actively involved in the leadership of many of our ophthalmologic societies, including as a member of the Board of Directors of the Cornea Society, the Eye Bank Association of America, and the Contact Lens Association of Ophthalmologists. He also serves on several committees of the American Academy of Ophthalmology, including the Annual Meeting Program Committee, as well as The Council. He is also actively involved with the American Board of Ophthalmology. Dr Jeng is a past member of the editorial board of JAMA Ophthalmology, and he currently serves on the editorial boards of Ophthalmology, Eye, Cornea, Eye and Contact Lens (as an Associate Editor), and International Journal of Eye Banking.
Hispanic Residential Isolation, ADHD Diagnosis and Stimulant Treatment among Medicaid-insured Youth
Authors: Pennap Dinci , Burcu Mehmet , Safer Daniel J. , Zito Julie M. 
Published: April 2017

<p class="Pa8"><strong>Objective: </strong>This study aimed to evaluate a conceptual framework that assessed the effect of Hispanic residential isolation on Attention Deficit Hyperactivity Disorder (ADHD) health service utilization among 2.2 million publicly insured youth.</p><p class="Pa8"><strong>Design: </strong>Cross-sectional.</p><p class="Pa8"><strong>Setting: </strong>Medicaid administrative claims data for ambulatory care services from a US Pacific state linked with US census data.</p><p class="Pa8"><strong>Participants: </strong>Youth, aged 2-17 years, con­tinuously enrolled in 2009.</p><p class="Pa8"><strong>Main Outcome Measures: </strong>The percent annual prevalence and odds of ADHD diagnosis and stimulant use according to two measures of racial/ethnic residential isolation: 1) the county-level Hispanic isola­tion index (HI) defined as the population density of Hispanic residents in relation to other racial/ethnic groups in a county (&lt;.5; .5-.64; ≥.65); and 2) the proportion of Hispanic residents in a ZIP code tabulation area (&lt;25%; 25%-50%; &gt;50%).</p><p class="Default"><strong>Results: </strong>Among the 47,364 youth with a clinician-reported ADHD diagnosis, 60% re­ceived a stimulant treatment (N = 28,334). As the county level HI increased, Hispanic residents of ethnically isolated locales were significantly less likely to receive an ADHD diagnosis (adjusted odds ratio [AOR]=.92 [95% CI=.88-.96]) and stimulant use (AOR=.61 [95% CI=.59-.64]) compared with Hispanic youth in less isolated areas. At the ZIP code level, a similar pattern of reduced ADHD diagnosis (AOR=.81 [95% CI=.77-.86]) and reduced stimulant use (AOR=.65 [95% CI=.61-.69]) was observed as Hispanic residential isolation increased from the least isolated to the most isolated ZIP code areas.</p><p class="Default"><strong>Conclusions: </strong>These findings highlight the opportunity for Big Data to advance mental health research on strategies to reduce racial/ethnic health disparities, particularly for poor and vulnerable youth. Further exploration of racial/ethnic residential isola­tion in other large data sources is needed to guide future policy development and to target culturally sensitive interventions.</p><p class="Default"><em>Ethn Dis.</em>2017(2):85-94; doi:10.18865/ed.27.2.85.</p><br /><p> </p><p> </p>
STUDI KELAYAKAN WAKAF PRODUKTIF
Authors: Aji Gunawan 
Published: April 2017

<p><span>Abstract</span></p><p><span>Mosque as one of the objects of waqf can provide added value if managed productively. <span>Land of the mosque can be used for a variety productive activities according to the <span>principles of Islam. ! is study analyzes the aspects of marketing and " nancial aspects, <span>the feasibility study for the project productive endowments shopping block Masjid AlFairuz Pekalongan.<br /><span>The data used in the form of quantitative and qualitative data. Factors that will be <span>analyzed in the marketing aspects that shape the market, demand and supply, marketing <span>strategy (segmenting, targetting, and positioning), as well as the marketing mix strategy.<br /><span>Financial aspects of the Average Rate of Return, Payback Period, Net Present Value, <span>Internal Rate of Return , and Pro" tability Index. Th<span>e results of research projects developing productive waqf shopping block mosque <span>of Al-Fairuz Pekalongan is feasible. In the aspect of marketing, business managers have<br /><span>established a marketing strategy and marketing mix well. On the " nancial aspect, <span>the ARR value indicates the number of 59%, greater than the minimum accounting <span>rate of return of 7.30%. Payback Period calculation produces a value of 2 years, 6 <span>months, 29 days, less than the economic life of the project. Project NPV is positive <span>value of Rp 209,224,199.00. IRR of 20%, greater than the rate of return of deposits <span>mudaraba Islamic banks are used in the calculation (7.30%). PI calculation results <span>show 1.297193465 value greater than 1 (PI &gt; 1) .</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p><p><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><span><br /><span>Keywords:<em> Feasibility Study, Waqf Productive, marketing aspects, " nancial aspects</em></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><br /></span></span></p>
Health data on public trial: To what extent should patients control access to patient records?
Authors: Oswald Malcolm , Norris Ruth , Hassan Lamiece , Peek Niels , Tully Mary 
Published: April 2017

ABSTRACT
ObjectivesThe secondary use of health data for public and private good raises complex questions of privacy and governance. Such questions are ill-suited to opinion polling where citizens must choose quickly with little information between multiple choice answers. This project aims to extend our knowledge about what control informed citizens would seek over health records after participating in a deliberative process.
ApproachTwo citizens’ juries, of 17 citizens each, were convened; each jury was chosen to reflect national demographics, from a pool of almost 400 volunteers. Juries met separately over three days, to address the charge “To what extent should patients control access to patient records for secondary use?” Citizens heard from and questioned five expert witnesses (chosen either to inform the jury, or to air arguments for and against the secondary use of data), interspersed with opportunities to deliberate amongst themselves, using a range of tools including facilitated discussion and guided role-play. Jurors voted on a series of questions associated with the jury charge, giving their rationale. Individual views were polled at the beginning and end of the process against the jury charge.
ResultsThirty-three out of 34 jurors voted in support of the secondary use of data, with 24 wanting individuals to be able to opt-out and 6 favouring opt-in. Many jurors changed their opinion about who should get access to these records, with more people supporting wider information sharing by the end of day 3. When considering who should get access to data, the two juries had very similar rationales. Both thought that public benefit was a key justification for access. Jury 1 was more strongly supportive of sharing patient records for public benefit, whilst jury 2 was more cautious and sought to give patients more control. The questionnaire results suggest that over the course of three days a few people moved towards more patient control over patient records, but overall more people moved towards enabling greater sharing of health data for public benefit. Despite our endeavours to ensure otherwise, bias was reported by a few jurors, particularly regarding the impartiality of information from expert witnesses.
ConclusionThese findings illustrate that citizens often change their minds about complex policy questions when they become more informed about a public policy problem. It may also suggest that many, but not all, people become less sceptical about health data sharing as they become better informed of its benefits and risks.
Opportunities for post-market surveillance of high cost medicines in Australia: Observing trastuzumab-treated women from early through late stage HER2-positive breast cancer (HER2BC)
Authors: Daniels Benjamin , Pearson Sallie-Anne 
Published: April 2017

ABSTRACT
ObjectivesIn 2001 the Australian government circumvented traditional drug subsidy listing processes to create the Herceptin Program (HP) for HER2 metastatic breast cancer (MBC) patients; in 2006 trastuzumab was subsidised for early breast cancer (EBC) on the Pharmaceutical Benefits Scheme (PBS) creating opportunities for data linkage and observing patients across both treatment settings. Clinical trials established the efficacy of trastuzumab for MBC in trastuzumab-naïve patients but little is known about patients initiating trastuzumab in the adjuvant setting and subsequently receiving trastuzumab for MBC. We characterise patterns of treatment and outcomes for these patients in Australia. We estimate time from adjuvant trastuzumab initiation to metastatic trastuzumab initiation and overall survival (OS).
ApproachWe identified a cohort of patients with a trastuzumab claim in both PBS and HP records. We calculated duration of EBC treatment as date of first trastuzumab dispensing until 21 days after the last PBS dispensing for trastuzumab or observation of a trastuzumab dispensing record in HP claims, whichever came first. We used Kaplan-Meier methods to estimate time-to-MBC treatment and OS.
ResultsOf 11,477 EBC patients treated with trastuzumab between December 2006 and December 2012, 637 were also treated with trastuzumab for MBC. Median age at EBC treatment initiation was 53 (range 17 – 87). 94% of EBC patients received a taxane, anthracycline, cyclophosphamide and/or carboplatin as part of their treatment protocol. 61% of MBC patients received trastuzumab with a taxane, 18% as monotherapy and 7% with capecitabine. Median duration of trastuzumab therapy in EBC and MBC therapy was 11.3 (95% CI 10.7-11.6) and 9.3 (8.6-10.4) months, respectively. Median time-to-MBC therapy was 27.3 (25.5-28.2) months. Median OS from initiation of EBC and MBC treatment was 58.1 (52.9-65.7) and 23.2 (20.5-25.4) months, respectively.
ConclusionHER2BC patients initiating trastuzumab for EBC therapy and progressing to MBC treatment are little examined in the clinical trial and observational literature. Australia’s unique funding arrangements allowed us to clearly distinguish between treatment for EBC and MBC which is not always possible in dispensing claims alone. We demonstrated: most EBC patients are treated according to guideline recommendations; that this patient cohort receive approximately 20 months of trastuzumab therapy across both settings; and median OS from initiation of MBC trastuzumab is approximately 2 months shorter than in the pivotal clinical trial (25.1 months).
No Strings Attached: Evaluating an Unconditional Prenatal Income Supplement Using Linked Administrative Data
Authors: Brownell Marni , Chartier Mariette , Nickel Nathan , Chateau Dan , Sarkar Joykrishna , Burland Elaine , Jutte Doug , Taylor Carole , Santos Rob , Katz Alan 
Published: April 2017

ABSTRACT
ObjectivePerinatal outcomes have improved overall in developed countries over the last several decades but remain poor for disadvantaged populations. In Manitoba, Canada, the Healthy Baby Prenatal Benefit (HBPB), a cash transfer to low-income pregnant women, was introduced with the goal of improving perinatal outcomes. The objective of this study was to use linked administrative and program datasets to determine whether this unconditional income supplement was associated with improved birth outcomes for a low-income population.
ApproachThis study used data from the PATHS Data Resource, which contains population-level health and social service records as well as program data for approximately 600,000 children in Manitoba, Canada, over a 30-year period, linkable at the individual level. All mother-newborn pairs, from 2003-2010, who met the following criteria were included for analyses: i) the mother was on social assistance (i.e., low income); ii) the infant was born in hospital; and, iii) the pair had a newborn risk screen (n=14,591), documenting factors such as prenatal alcohol and tobacco exposure and maternal and family characteristics. Low-income women who received HBPB (exposed, 10,738) were compared with low-income women who did not receive HBPB (unexposed, 3,853) on several outcomes: low birth weight, preterm, small- and large-for-gestational age, 5-minutes Apgar scores, breastfeeding initiation, neonatal readmission, and newborn hospital length of stay (LOS). Covariates from the risk screens were used to develop propensity scores to construct Inverse Probability of Treatment Weights, to balance differences between exposed and unexposed groups in regression models. Gamma sensitivity analyses assessed sensitivity to unmeasured confounding. Population attributable and preventable fractions were calculated.
ResultsHBPB exposure was associated with reductions in low birth weight (adjusted risk ratio, aRR=0.71, 95% CI=0.63, 0.81), preterm (aRR=0.76 (0.69, 0.84)) and small-for-gestational age (aRR=0.90 (0.81, 0.99)) births and increases in breastfeeding (aRR=1.06 (1.03, 1.09)) and large-for-gestational age births (aRR=1.13 (1.05, 1.23)). For vaginal births, HBPB was associated with shortened LOS (mean=2.86, p<0.0001). Results for breastfeeding, low birth weight, preterm and LOS were robust to unmeasured confounding. Reductions of 21% (95% CI 13.6, 28.3) of low birth weight and 17.5% (11.2, 23.8) of preterm were associated with receipt of the HBPB.
ConclusionsA modest income supplement during pregnancy was associated with improved birth outcomes for infants born to low-income women. Placing conditions on income supplements to low income pregnant women may not be necessary to promote prenatal and perinatal health. Linked administrative data can be a valuable tool for program evaluation.
Displaying Linkage Success Statistics to Identify Systemic Errors
Authors: Simpson Mike , Yip Harold , Hills Brent 
Published: April 2017

ABSTRACT
ObjectiveThe primary objective is to create a method for displaying linkage statistics to researchers, data stewards, and linkage specialists in an informative and meaningful way. The method must visually display the linkage summary data and highlight drops in the linkage success rate.
ApproachWe created a web interface which shows linkage statistics by age and geography in calendar/service years. Each cell contains both the percentage of linked values along with the percentage of successfully linked data. The interface is filterable by gender, data-type, and whether to display the number of successful or unsuccessful linkages. Due to the high volume of data which will appear on the screen at one time, we use a heat map to highlight cells which have unusually high or low values. Totals are displayed with their own heat maps to compare easily years across ages group or age groups across years. We mask small cell sizes to preserve privacy.
ResultsThis approach allows people to easily spot drops in linkage success. If a particular year’s data or age group has a lower linkage rate than the rest of the dataset, the heat map can clearly highlight that discrepancy. Displaying the number of linkages along with the rate helps us determine if the sample size is playing a role in a low linkage success rate.
ConclusionData quality issues can silently cause linkage success rates to drop in certain years, geographies, age groups, or genders. Displaying linkage statistics on a single page with a heat map allows people to quickly spot inconsistencies in linkages.
Quantifying morbidity attributable to traumatic injury using a population-based matched cohort in Australia
Authors: Mitchell Rebecca , Cameron Cate , McClure Rod 
Published: April 2017

ABSTRACT
ObjectiveThis study aims to quantify 12-month morbidity attributable to traumatic injury using a population-based matched cohort in Australia.
ApproachA population-based matched cohort study of individuals ≥18 years using linked emergency department (ED) presentation, hospital separation and mortality records from three Australian states during 1 January 2008 to 31 December 2010. Injury admissions were identified using a principal diagnosis of injury (ICD-10-AM: S00-T75 or T79). The first injury-related hospital admission during 2009 was identified as the index injury admission and pre and post-index injury health service use was examined. The non-injured comparison cohort was randomly selected from the electoral roll and was matched 1:1 on age, gender, and postcode of residence at the date of the index injury admission of their matched counterpart. Comorbidities were identified using diagnosis classifications and a 1-year lookback period. Injury severity was estimated using the International Classification of Injury Severity Score (ICISS): minor (≥0.99), moderate (0.942-<0.99) and serious (<0.942).
Negative binomial and Poisson regression methods will be used to quantify associations between injury and counts of hospital admissions 12-month post-index injury health service use.
ResultsThere were 166,032 individuals injured in 2009 and admitted to hospital in New South Wales, South Australia or Queensland with a matched comparison. Males represented 57% of those injured, 30.1% were aged 18-34 years, 37.9% were aged 35-64 years, 32.1% were aged ≥65 years and 65.1% resided in an urban location. Comorbidities were more common in the injured cohort (χ² =9384.5, df (2), p<0.0001). The most common injuries were fall-related (38.4%) and as a result of road trauma (12.4%). The majority of injuries were minor (43.9%) or moderate (37.2%), with 18.9% serious injuries. Attributable risk and adjusted rate ratios for injured versus matched non-injured comparison will be presented for pre and post health service use controlling for key confounding characteristics.
ConclusionThrough the use of national data linkage, this study contributes to informing research efforts on better quantifying the attributable burden of injury-related disability in Australia.
Assessing mental health outcomes for residents of supported accommodation services
Authors: Sims Scott , Lima Fernando , Moltoni Michael , Harrison Amanda , Glauert Rebecca 
Published: April 2017

ABSTRACT
ObjectivesSupported accommodation services provide housing for people with a severe and persistent mental illness; people who are homeless, at risk of homelessness, in unsuitable accommodation, or residing for long periods in inpatient units. The aim of this research is to examine the extent to which supported accommodation impacts on levels and costs of hospitalisation, utilisation of community based clinical services and mental health outcomes of present and past residents.
ApproachThe research will make use of demographic data from supported accommodation services and Western Australian (WA) linked data from existing health data collections by the Data Linkage Branch WA Health. The data linkage methodology used involves the linking and analysis of data between 1997 and 2013 from a diverse number of datasets (Hospital Morbidity data, Mental Health Ambulatory data, Emergency data, Mortality data and Hospital Cost data). The impact of supported accommodation on individuals was measured by tracking any changes in their service utilisation levels and associated hospital costs savings. This allowed us to determine the efficacy of supported accommodation services through time series and control group comparative analysis.
ResultsPeople with severe or persistent mental illness who reside in supported accommodation services are more likely to maintain or improve their quality of life and mental health outcomes compared to those who have never entered supported accommodation. Individuals who utilised these services also experienced reduced hospitalizations after the service than before. Cost implications will also be discussed.
Conclusions No significant research into the effectiveness of supported accommodation on mental health outcomes for individuals has been conducted in WA to date. Supported accommodation provides people with severe and persistent mental illness, along with their families, carers and supporters, more security and control over their lives, and improved access to appropriate supports and clinical services. This research will support these strategic directions by providing evidence about the effectiveness of supported accommodation options in terms of improving mental health outcomes for individuals.