bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing communication and decision-making about life-sustaining technology during serious illness: a qualitative study
Authors: Kryworuchko Jennifer , Strachan P H , Nouvet E , Downar J , You J J 
Published: May 2016

ObjectivesWe aimed to identify factors influencing communication and decision-making, and to learn how physicians and nurses view their roles in deciding about the use of life-sustaining technology for seriously ill hospitalised patients and their families.DesignThe qualitative study used Flanagan's critical incident technique to guide interpretive description of open-ended in-depth individual interviews.SettingParticipants were recruited from the medical wards at 3 Canadian hospitals.ParticipantsInterviews were completed with 30 healthcare professionals (9 staff physicians, 9 residents and 12 nurses; aged 25–63 years; 73% female) involved in decisions about the care of seriously ill hospitalised patients and their families.MeasuresParticipants described encounters with patients and families in which communication and decision-making about life-sustaining technology went particularly well and unwell (ie, critical incidents). We further explored their roles, context and challenges. Analysis proceeded using constant comparative methods to form themes independently and with the interprofessional research team.ResultsWe identified several key factors that influenced communication and decision-making about life-sustaining technology. The overarching factor was how those involved in such communication and decision-making (healthcare providers, patients and families) conceptualised the goals of medical practice. Additional key factors related to how preferences and decision-making were shaped through relationships, particularly how people worked toward ‘making sense of the situation’, how physicians and nurses approached the inherent and systemic tensions in achieving consensus with families, and how physicians and nurses conducted professional work within teams. Participants described incidents in which these key factors interacted in dynamic and unpredictable ways to influence decision-making for any particular patient and family.ConclusionsA focus on more meaningful and productive dialogue with patients and families by (and between) each member of the healthcare team may improve decisions about life-sustaining technology. Work is needed to acknowledge and support the non-curative role of healthcare and build capacity for the interprofessional team to engage in effective decision-making discussions.
STAT3/IRF1 Pathway Activation Sensitizes Cervical Cancer Cells to Chemotherapeutic Drugs
Authors: Walch-Rückheim Barbara , Pahne-Zeppenfeld Jennifer , Fischbach Jil , Wickenhauser Claudia , Horn Lars Christian , Tharun Lars , Büttner Reinhard , Mallmann Peter , Stern Peter , Kim Yoo-Jin , Bohle Rainer Maria , Rübe Christian , Ströder Russalina , Juhasz-Böss Ingolf , Solomayer Erich-Franz , Smola Sigrun 
Published: May 2016

Abstract
Neoadjuvant radio/chemotherapy regimens can markedly improve cervical cancer outcome in a subset of patients, while other patients show poor responses, but may encounter severe adverse effects. Thus, there is a strong need for predictive biomarkers to improve clinical management of cervical cancer patients. STAT3 is considered as a critical antiapoptotic factor in various malignancies. We therefore investigated STAT3 activation during cervical carcinogenesis and its impact on the response of cervical cancer cells to chemotherapeutic drugs. Tyr705-phosphorylated STAT3 increased from low-grade cervical intraepithelial neoplasia (CIN1) to precancerous CIN3 lesions. Notably, pTyr705-STAT3 activation significantly declined from CIN3 to invasive cancer, also when compared in the same clinical biopsy. pTyr705-STAT3 was also low or absent in cultured human cervical cancer cell lines, consistent with the in vivo expression data. Unexpectedly, IL6-type cytokine signaling inducing STAT3 activation rendered cervical cancer cells significantly more susceptible to chemotherapeutic drugs, that is, cisplatin or etoposide. This chemosensitization was STAT3-dependent and we identified IFN regulatory factor-1 (IRF1) as the STAT3-inducible mediator required for cell death enhancement. In line with these data, pTyr705-STAT3 significantly correlated with nuclear IRF1 expression in cervical cancer in vivo. Importantly, high IRF1 expression in pretreatment cervical cancer biopsy cells was associated with a significantly better response to neoadjuvant radio/chemotherapy of the patients. In summary, our study has identified a key role of the STAT3/IRF1 pathway for chemosensitization in cervical cancer. Our results suggest that pretherapeutic IRF1 expression should be evaluated as a novel predictive biomarker for neoadjuvant radio/chemotherapy responses. Cancer Res; 76(13); 3872–83. ©2016 AACR.
YAP Mediates Tumorigenesis in Neurofibromatosis Type 2 by Promoting Cell Survival and Proliferation through a COX-2–EGFR Signaling Axis
Authors: Guerrant William , Kota Smitha , Troutman Scott , Mandati Vinay , Fallahi Mohammad , Stemmer-Rachamimov Anat , Kissil Joseph L. 
Published: May 2016

Abstract
The Hippo–YAP pathway has emerged as a major driver of tumorigenesis in many human cancers. YAP is a transcriptional coactivator and while details of YAP regulation are quickly emerging, it remains unknown what downstream targets are critical for the oncogenic functions of YAP. To determine the mechanisms involved and to identify disease-relevant targets, we examined the role of YAP in neurofibromatosis type 2 (NF2) using cell and animal models. We found that YAP function is required for NF2-null Schwann cell survival, proliferation, and tumor growth in vivo. Moreover, YAP promotes transcription of several targets including PTGS2, which codes for COX-2, a key enzyme in prostaglandin biosynthesis, and AREG, which codes for the EGFR ligand, amphiregulin. Both AREG and prostaglandin E2 converge to activate signaling through EGFR. Importantly, treatment with the COX-2 inhibitor celecoxib significantly inhibited the growth of NF2-null Schwann cells and tumor growth in a mouse model of NF2. Cancer Res; 76(12); 3507–19. ©2016 AACR.
Circulating Omentin as a Novel Biomarker for Colorectal Cancer Risk: Data from the EPIC–Potsdam Cohort Study
Authors: Aleksandrova Krasimira , di Giuseppe Romina , Isermann Berend , Biemann Ronald , Schulze Matthias , Wittenbecher Clemens , Fritsche Andreas , Lehmann Rainer , Menzel Juliane , Weikert Cornelia , Pischon Tobias , Boeing Heiner 
Published: May 2016

Abstract
Omentin is a novel biomarker shown to exert metabolic, inflammatory, and immune-related properties and thereby could be implicated in the risk of colorectal cancer. So far, the association between omentin and colorectal cancer risk has not been evaluated in prospective cohort studies. We investigated the association between prediagnostic plasma omentin concentrations and risk of colorectal cancer in a case–cohort comprising 251 incident colorectal cancer cases diagnosed over a mean follow-up time of 10.4 years and 2,295 persons who remained free of cancer in the European Prospective Investigation into Cancer and Nutrition-Potsdam study. Hazard ratios as a measure of relative risk (RR) and 95% confidence intervals (CI) were computed using a Prentice-modified Cox regression. In a multivariable model adjusted for age, sex, education, dietary and lifestyle factors, body mass index (BMI), and waist circumference, higher omentin concentrations were associated with a higher colorectal cancer risk (RRcontinuously per doubling of omentin concentrations = 1.98; 95% CI, 1.45–2.73). Additional adjustment for metabolic biomarkers, including glycated hemoglobin, high-density lipoprotein cholesterol, and C-reactive protein, did not alter the results. In stratified analyses, the positive association between omentin and colorectal cancer risk was retained in participants with BMI &lt; 30 (RRcontinuously per doubling of omentin concentrations = 2.26; 95% CI, 1.57–3.27), whereas among participants with BMI ≥ 30 no association was revealed (RRcontinuously per doubling of omentin concentrations = 1.07; 95% CI, 0.63–1.83; Pinteraction = 0.005). These novel findings provide the first lines of evidence for an independent association between prediagnostic omentin concentrations and colorectal cancer risk and suggest a potential interaction with the adiposity state of the individual. Cancer Res; 76(13); 3862–71. ©2016 AACR.
JNK1 Inhibition Attenuates Hypoxia-Induced Autophagy and Sensitizes to Chemotherapy
Authors: Vasilevskaya Irina A. , Selvakumaran Muthu , Roberts David , O'Dwyer Peter J. 
Published: May 2016

Abstract
Inhibition of hypoxia-induced stress signaling through JNK potentiates the effects of oxaliplatin. The JNK pathway plays a role in both autophagy and apoptosis; therefore, it was determined how much of the effect of JNK inhibition on oxaliplatin sensitivity is dependent on its effect on autophagy. We studied the impact of JNK isoform downregulation in the HT29 colon adenocarcinoma cell line on hypoxia- and oxaliplatin-induced responses. Electron microscopic analyses demonstrated that both oxaliplatin- and hypoxia-induced formations of autophagosomes were reduced significantly in HT29 cells treated with the JNK inhibitor SP600125. The role of specific JNK isoforms was defined using HT29-derived cell lines stably expressing dominant-negative constructs for JNK1 and JNK2 (HTJ1.3 and HTJ2.2, respectively). These cell lines demonstrated that functional JNK1 is required for hypoxia-induced autophagy and that JNK2 does not substitute for it. Inhibition of autophagy in HTJ1.3 cells also coincided with enhancement of intrinsic apoptosis. Analysis of Bcl2-family proteins revealed hyperphosphorylation of Bcl-XL in the HTJ1.3 cell line, but this did not lead to the expected dissociation from Beclin 1. Consistent with this, knockdown of Bcl-XL in HT29 cells did not significantly affect the induction of autophagy, but abrogated hypoxic resistance to oxaliplatin due to the faster and more robust activation of apoptosis.
Implications: These data suggest that balance between autophagy and apoptosis is shifted toward apoptosis by downregulation of JNK1, contributing to oxaliplatin sensitization. These findings further support the investigation of JNK inhibition in colorectal cancer treatment. Mol Cancer Res; 14(8); 753–63. ©2016 AACR.
CITED2 Modulates Breast Cancer Metastatic Ability through Effects on IKKα
Authors: Jayaraman Swaathi , Doucet Michele , Lau Wen Min , Kominsky Scott L. 
Published: May 2016

AbstractPreviously, we identified the transcriptional coactivator CITED2 as a potential facilitator of bone metastasis using a murine mammary cancer model. Extending these studies to human breast cancer, it was observed that CITED2 mRNA expression was significantly elevated in patient specimens of metastatic breast cancer relative to primary tumors, with highest levels in metastasis to bone relative to non-bone sites. To further evaluate CITED2 functions in breast cancer metastasis, CITED2 expression was stably reduced in the human breast cancer cell lines MDA-MB-231 and MDA-MB-468, which are metastatic in animal models. While CITED2 knockdown had no effect on cell proliferation, cell migration and invasion were significantly reduced, as was the establishment of metastasis following intracardiac administration in athymic nude mice. To explore the mechanism behind these effects, gene expression following CITED2 knockdown in MDA-MB-231 cells by cDNA microarray was performed. As confirmed at the mRNA and protein levels in both MDA-MB-231 and MDA-MB-468 cells, expression of the NF-κB regulator IKKα was significantly reduced, along with several NF-κB targets with known roles in metastasis (OPN, MMP9, uPA, SPARC, IL11, and IL1β). Furthermore, ChIP assay revealed recruitment of CITED2 to the promoter of IKKα, indicating a direct role in regulating its expression. Consistent with reduced IKKα expression, CITED2 knockdown inhibited both canonical and noncanonical NF-κB signaling. Finally, restoration of IKKα expression following CITED2 knockdown in MDA-MB-231 and MDA-MB-468 cells rescued their invasive ability. Collectively, these data demonstrate that CITED2 modulates metastatic ability in human breast cancer cells, at least in part, through the regulation of IKKα.Implications: The current study highlights the role of CITED2 in facilitating breast cancer metastasis, partly via regulation of IKKα. Mol Cancer Res; 14(8); 730–9. ©2016 AACR.
Application of Metal Implant 16-Bit Imaging: New Technique in Radiotherapy
Authors: Xin-ye Ni , Liugang Gao , Mingming Fang , Tao Lin 
Published: May 2016

Objective: This study aimed to evaluate the computed tomography number and the variation of dose distribution based on 12-bit, 16-bit, and revised 16-bit images while the metal bars were inserted. Methods: The phantoms containing stainless steel, titanium alloy, and aluminum bar were scanned with computed tomography. These images were reconstructed with 12-bit and 16-bit imaging technologies. The “cupping artifacts” computed tomography value of the metal object revised by Matlab software was called the revised 16-bit image. The computed tomography values of these metal materials were analyzed. Two radiotherapy treatment plans were designed using the treatment plan system: (1) gantry was of 0° irradiation field and (2) gantry was of 90° and 270° for 2 opposed irradiation fields. The dose profile and dose–volume histogram of a structure of interest were analyzed in various images. The analysis was based on the radiotherapy plan differences between 3 different imaging techniques (12-bit imaging, 16-bit imaging, and revised 16-bit imaging technologies). Results: For low-density metal object (computed tomography value <3071 Hounsfield unit, HU), the radiotherapy plan results were consistent based on 3 different imaging techniques. For high-density metal object (computed tomography value >3071 HU), the difference in radiotherapy plan results was obvious. The dose of 12-bit was 15.9% higher than revised 16-bit on average for the downstream of titanium rod. For stainless steel, this number reached up to 42.7%. Conclusion: A 16-bit imaging technology of metal implants can distinguish the computed tomography value of different metal materials. Furthermore, the revised 16-bit imaging technology can improve the dose computational accuracy of radiotherapy plan with high-density metal implants.
�Book Supply� Service As a Tool for Simulation of Methodological Support of Educational Process
Authors: �������  , Baryshev R. 
Published: May 2016

The article describes the issues of educational process book supply according to the requirements of the Federal State Educational Standards. This paper
presents opportunities to solve these issues with the help of the �Book Supply� service. The paper has considered regulation of university structural divisions
interaction on the organization of the �Book Supply� database, defi nes the tasks and prospects for improving the quality of the educational process
methodological support.
Analisis Energi Osilator Harmonik Menggunakan Metode Path Integral Hypergeometry dan Operator
Authors: Sholihah Fuzi Marati , S Suparmi , Variani Viska Inda 
Published: May 2016

<span>Solution of the harmonic oscillator equation has a goal to get the energy levels of particles <span>moving harmonic. The energy spectrums of one dimensional harmonic oscillator are <span>analyzed by 3 methods: path integral, hypergeometry and operator. Analysis of the energy <span>spectrum by path integral method is examined with Schrodinger equation. Analysis of the <span>energy spectrum by operator method is examined by Hamiltonian in operator. Analysis of <span>harmonic oscillator energy by 3 methods: path integral, hypergeometry and operator are <span>getting same results 𝐸 = ℏ𝜔 (𝑛 + <span>1 2<span>)</span></span></span></span></span></span><br /></span></span></span>
Sensor Fiber Optik Dari Bahan Fiber Optik Polimer Untuk Pengukuran Refractive Index Larutan Gula
Authors: Sari Nila Wulan , Marzuki Ahmad , R Riyatun 
Published: May 2016

<span>This paper presents an experimental result on developing an optical fiber sensor for <span>measuring refractive index of sugar solution. Sensor was developed using polymer optical <span>fiber with diameter of 3 mm. This sensor is working based on intensity modulation due to <span>reflection. Light coming out from the transmitter optical fiber is reflected by a mirror to the <span>receiver optical fiber. Due to the variation of sugar concentration in solution surrounding <span>this sensor, the way of light entering the fiber receiver depends on the sugar concentration <span>(numerical aperture). It is clear from the experiment that light intensity detected by <span>photodetector (represented by electric voltage) is linearly dependent (R<span>2 <span>= 0.987) on the <span>variation of sugar solution refractive index.</span></span></span></span></span></span></span></span><br /></span></span></span>
Kinerja Inkubator Bayi dengan Pemanas Tanpa Listrik yang Dilengkapi Unit Pemantau Suhu dan Kelembaban Udara
Authors: W Wihantoro , Aziz Abdullah N , Effendi Mukhtar , Raharjo Sukmaji A 
Published: May 2016

<span>An infant incubator utilizing a non-electrical heater element and an add-on temperature and <span>relative humidity controlling unit has been produced. Copper pipe in planar spiral construction <span>which usually found as a radiator element in refrigerator was used as the heater element. Once <span>the hot water filled into the element, it will served as heat energy source for (40 x 58 x 40) cm<span>3<br /><span>volume of incubator’s baby compartment. Compartment’s performance (<span><em>P</em><span>) in providing the <span>heat energy was to be found as 0.4 J/s and the average constant temperature achievable was <span>34.2 <span>o<span>C. Two of LM35 ICs were operated as dry and wet sensor each and served as the input <span>for temperature and humidity quantities for baby’s compartment. These both sensors were set <span>by CV-AVR package program which then was loaded into the ATMega8535 chip. An LCD<br /><span>screen of 20x2 matrices was then used in displaying these both quantities. Dry and wet <span>temperature sensors which were used to acquire the value of air temperature and relative <span>humidity within baby’s compartment to be found have sensitivity value of 0.02 0.01 volt/<span>o<span>C <span>and 0.03 0.01 volt/<span>o<span>C, each.</span></span></span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span></span></span></span></span></span>
Sintesis Nanopartikel Cobalt Ferrite (CoFe2O4) dengan Metode Kopresipitasi dan Karakterisasi Sifat Kemagnetannya
Authors: Setiadi Eko Arief , Shabrina Nanda , Budi Utami Hesti Retno , Fahmi Nur Fadhilah , Kato Takeshi , Iwata Satoshi , Suharyadi Edi 
Published: May 2016

<span>Magnetic nanoparticles of cobalt ferrite (CoFe<span>2<span>O<span>4<span>) have been synthesized by co-precipitation <span>method with various synthesis temperature and concentration of NaOH. The structural <span>characteristics and particle size of CoFe<span>2<span>O<span>4 <span>were determined by X-ray diffraction (XRD) and <span>Transmission Electron Microscopy (TEM), its showed that nanoparticles well crystallized with <span>various grain size which depend on synthesis parameters. The grain sizes estimated using the <span>Scherrer formula were found that the grain size increased with increasing temperature <span>synthesis and decreasing concentration of NaOH. Magnetic characterization of CoFe<span>2<span>O<span>4 <span>nanoparticles was investigated by using a Vibrating Sample Magnetometer (VSM). Sample <span>with various concentration of NaOH showed that coercivity was decrease with the decrease of <span>particle size. In other hand, samples with various synthesis temperature found that sample with<br /><span>smallest grain size have high coersivity. The saturation magnetization increase when <span>crystallinity increase. Based on the results, it can be concluded that magnetic characterization <span>of CoFe<span>2<span>O<span>4 <span>was influenced by grain size and crystallinity.</span></span></span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span>
Pengaruh Substitusi Ion Mn dan Ion Co Serta Ion Ti pada Pembentukan Fasa dan Sifat Magnetik Barium Hexaferrite BaFe9(MnCo)1,5Ti1,5O19 Disintesis Melalui Rute Metallurgi Serbuk
Authors: P Priyono , Siradj Eddy , Manaf Azwar 
Published: May 2016

<span>Barium ferrite with hexagonal molecular BaFe<span>12<span>O<span>19 <span>is well-known for its high performance <span>permanent magnetic and good mechanical properties and attracted attention of researchers for <span>a long time. The hexaferrite powders were produced according to a conventional ceramic <span>process with powder metallurgy method. Moreover, the powders were analyzed by X-ray <span>diffraction, to detect the presence of secondary phases. The magnetic properties of the samples <span>were measured at room temperature using Permeagraph with a maximum applied field of 1.5 <span>T. The calculation of the lattice parameter on conventional magnets (BaFe<span>12<span>O<span>19<span>) results a = b = <span>5,894 Å and c = 23,210 Å, while the substituted phase has a range value of a = b between <span>5,893 Å to 5,899 Å, and c lattice parameter value is in the range of 23,328 ˚A to 23,346 Å. <span>With the partial substitution of Fe<span>+3 <span>ions by Mn<span>+2 <span>ions, ion Co<span>+2 <span>and Ti<span>+4 <span>ion magnetic<br /><span>properties decrease primarily on the magnetic coercivity from 125 kA / m (conventional) to ~ 5 <span>kA /m in the substituted materials.</span></span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span>
Perhitungan Energi Disosiasi Gugus Fungsi OH- dan PO43- Hidroksiapatit dengan Pemodelan Spektroskopi Inframerah Berbasis Particle Swarm Optimization (PSO)
Authors: Yakin Khusnul , Pramudito Sidikrubadi , Dahlan Kiagus 
Published: May 2016

<span>Hydroxyapatite Ca<span>10<span>(PO<span>4<span>)<span>6<span>(OH)<span>2 <span>is a calcium phosphate compound having biocompatibility <span>properties. FTIR (Fourier Transform Infrared Spectroscopy) was used to determine the <span>characteristics of the hydroxyapatite group. Modeling the functional groups of hydroxyapatite <span>can be used to obtain vibrational frequencies and spring constants. Analysis of energy release <span>function is performed by calculating the dissociation energy. In this paper will be shown the <span>results of theoretical modeling of hydroxyl and phosphate using spring models. Modeling the <span>functional groups OH<span>- <span>obtained spring constant 524,4559 N/m and the absorption wave number <span>3497,5677 cm<span>-1<span>. Modelling functional groups PO<span>43-<span>obtained spring constant 612,2704 N/m <span>and the wave number 1085,2559 cm<span>-1 <span>absorption. The constant and absorption wave numbers <span>obtained are used to calculate the dissociation energy. OH<span>- <span>dissociation energy obtained by <span>566,5637 kJ/mol and the dissociation energy of PO<span>43- <span>is 567,6248 kJ/mol. Absorption wave <span>numbers are obtained in accordance with experimental results on sometrik stretch modes, and <span>the dissociation energy derived functional group is also close to the value of literature.</span></span></span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span>