bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lung Injury Combined with Loss of Regulatory T Cells Leads to De Novo Lung-Restricted Autoimmunity
Authors: Chiu Stephen , Fernandez Ramiro , Subramanian Vijay , Sun Haiying , DeCamp Malcolm M. , Kreisel Daniel , Perlman Harris , Budinger G. R. Scott , Mohanakumar Thalachallour , Bharat Ankit 
Published: May 2016

Abstract
More than one third of patients with chronic lung disease undergoing lung transplantation have pre-existing Abs against lung-restricted self-Ags, collagen type V (ColV), and k-α1 tubulin (KAT). These Abs can also develop de novo after lung transplantation and mediate allograft rejection. However, the mechanisms leading to lung-restricted autoimmunity remain unknown. Because these self-Ags are normally sequestered, tissue injury is required to expose them to the immune system. We previously showed that respiratory viruses can induce apoptosis in CD4+CD25+Foxp3+ regulatory T cells (Tregs), the key mediators of self-tolerance. Therefore, we hypothesized that lung-tissue injury can lead to lung-restricted immunity if it occurs in a setting when Tregs are impaired. We found that human lung recipients who suffer respiratory viral infections experienced a decrease in peripheral Tregs. Pre-existing lung allograft injury from donor-directed Abs or gastroesophageal reflux led to new ColV and KAT Abs post respiratory viral infection. Similarly, murine parainfluenza (Sendai) respiratory viral infection caused a decrease in Tregs. Intratracheal instillation of anti-MHC class I Abs, but not isotype control, followed by murine Sendai virus infection led to development of Abs against ColV and KAT, but not collagen type II (ColII), a cartilaginous protein. This was associated with expansion of IFN-γ–producing CD4+ T cells specific to ColV and KAT, but not ColII. Intratracheal anti-MHC class I Abs or hydrochloric acid in Foxp3-DTR mice induced ColV and KAT, but not ColII, immunity, only if Tregs were depleted using diphtheria toxin. We conclude that tissue injury combined with loss of Tregs can lead to lung-tissue–restricted immunity.
The Relationship between Religious Coping Strategies and Happiness with Meaning in Life in Blind People
Authors: Abarghouei Mehdi , Sorbi Mohammad Hossein , Abarghouei Mohammad Reza , Bidaki Reza 
Published: May 2016

The aim of this study was studying the relationship between religious coping strategies and happiness with meaning in life in blind people in Iran in 2015. This research was a Correlation study with sample size of 103 blind people (17 to 55 years) of Yazd in Iran, selected by convenience sampling method. Data were gathered by Islamic Coping Strategies Scale (ICSS), Oxford Happiness Inventory (OHI) and Meaning in Life Questionnaire (MLQ). SPSS-16 was used for analyzing data. Correlation coefficient results showed a positive significant correlation between religious coping strategies (Cognitive, Behavioral and Emotional) and happiness with meaning in life, also there was a positive significant correlation between religious coping strategies and happiness (p < 0.01). T-test showed that there was no significant difference between religious coping strategies, happiness and meaning in life in male and female blind people (p > 0.05). Stepwise regression showed that happiness, emotional, cognitive and behavioral subscales were respectively the strongest predictors for meaning in life. It can be concluded that religious and spirituality among blind people help them faced life's challenges more logically. This factor has an important role on increasing the levels of happiness and meaning in life.
Becker’s theory on crime and punishment, a useful guide for law enforcement policy in The Netherlands?
Authors: van Velthoven Ben , van Wijck Peter 
Published: May 2016

Becker’s theory on crime and punishment, a useful guide for law enforcement policy in The Netherlands?
Becker’s theory on crime and punishment provides guidelines for designing an optimal law enforcement policy. In designing such a policy the costs of law enforcement should be traded-off against the benefits that originate in deterring criminal acts. We investigate whether law enforcement policy in the Netherlands is consistent with this guidelines. Since policy makers are not very precise on the goals of law enforcement policy and hardly anything is known about the effectiveness and efficiency of instruments, it turns out to be impossible to say whether law enforcement policy actually contributes to social welfare. This is not necessarily problematic if, in line with the efficient law hypothesis, law enforcement automatically converges to an efficient outcome. Furthermore, Becker’s theory appears to miss a crucial element by not taking account of existing preferences for retribution. If utility is derived from seeing that justice is done, this should be included in the welfare criterion. Assuming policy makers prefer welfare enhancing law enforcement, they would be well-advised to start systematically collecting information on the effectiveness and efficiency of instruments of law enforcement policy.
Room-temperature operation of GaInAsP lasers epitaxially grown on wafer-bonded InP/Si substrate
Authors: Matsumoto Keiichi , Kishikawa Junya , Nishiyama Tetsuo , Kanke Tomokazu , Onuki Yuya , Shimomura Kazuhiko 
Published: May 2016

Abstract
An epitaxially grown GaInAsP/InP double-hetero laser diode (LD) has been demonstrated on a wafer-bonded InP/Si substrate for the first time. The as-grown structure was optically active and exhibited a photoluminescence intensity comparable to that grown on an InP wafer as a reference. Electrodes were formed on both the p-side contact layer and the n-Si underside to fabricate Fabry–Perot LD chips. During these processes, the InP layer remained bonded to the underlying Si substrate. Electrically pumped lasing emission was observed at room temperature under a pulse regime. These results indicate the potential for the high-density integration of InP-based LDs as a light source for optical interconnections.
Angular dependence of current-driven chiral walls
Authors: Martinez Eduardo , Alejos Oscar , Hernandez Maria Auxiliadora , Raposo Victor , Sanchez-Tejerina Luis , Moretti Simone 
Published: May 2016

Abstract
The current-driven dynamics of chiral domain walls is theoretically studied by means of realistic micromagnetic simulations. Trains of current pulses flowing through the heavy metal underneath the ferromagnetic layer are injected with different directions with respect to the ferromagnetic strip axis. The wall displacement is highly sensitive to the wall configuration and to the angle between the current and the longitudinal axis of the strip. These simulations can account for the experimental behavior at large currents, but preliminary results at lower current density point towards incompatibilities between the model and the experiment that need further experimental and theoretical efforts.
Decomposition of cellulose by ultrasonic welding in water
Authors: Nomura Shinfuku , Miyagawa Seiya , Mukasa Shinobu , Toyota Hiromichi 
Published: May 2016

Abstract
The use of ultrasonic welding in water to decompose cellulose placed in water was examined experimentally. Filter paper was used as the decomposition material with a horn-type transducer 19.5 kHz adopted as the ultrasonic welding power source. The frictional heat at the point where the surface of the tip of the ultrasonic horn contacts the filter paper decomposes the cellulose in the filter paper into 5-hydroxymethylfurfural (5-HMF), furfural, and oligosaccharide through hydrolysis and thermolysis that occurs in the welding process.
Numerical analysis for the optimum condition of ultrasonic nebulizing
Authors: Kim Jungsoon , Kim Jihyang , Ha Kanglyeol , Kim Moojoon 
Published: May 2016

Abstract
To obtain the optimal driving conditions for ultrasonic nebulizing, the capillary wave caused by ultrasound on the water surface was analyzed theoretically. From the possible solutions of Mathieu’s equation, the condition for amplitude diverging with time changes was investigated. The possible ranges of the driving frequency and the vibration displacement for nebulizing were obtained numerically, and the droplet size distribution was obtained in these ranges. The results of this study could be applied to design the desirable ultrasonic nebulizer.
Antitumor effect of sonodynamically activated pyrrolidine tris-acid fullerene
Authors: Iwase Yumiko , Nishi Koji , Fujimori Junya , Fukai Toshio , Yumita Nagahiko , Ikeda Toshihiko , Chen Fu-shin , Momose Yasunori , Umemura Shin-ichiro 
Published: May 2016

AbstractIn this study, the sonodynamically induced antitumor effect of pyrrolidine tris-acid fullerene (PTF) was investigated. Sonodynamically induced antitumor effects of PTF by focused ultrasound were investigated using isolated sarcoma-180 cells and mice bearing ectopically-implanted colon 26 carcinoma. Cell damage induced by ultrasonic exposure was enhanced by 5-fold in the presence of 80 µM PTF. The combined treatment of ultrasound and PTF suppressed the growth of the implanted colon 26 carcinoma. Ultrasonically induced 2,2,6,6-tetramethyl-4-piperidone-1-oxyl (4oxoTEMPO) production in the presence and absence of PTF was assessed, and it was shown that 80 µM PTF enhanced 4oxoTEMPO production as measured by ESR spectroscopy. Histidine, a reactive oxygen scavenger, significantly reduced cell damage and 4oxoTEMPO generation caused by ultrasonic exposure in the presence of PTF. These results suggest that singlet oxygen is likely to be involved in the ultrasonically induced cell damage enhanced by PTF.
The impact of energy barrier height on border traps in the metal insulator semicondoctor gate stacks on III–V semiconductors
Authors: Yoshida Shinichi , Taniguchi Satoshi , Minari Hideki , Lin Dennis , Ivanov Tsvetan , Watanabe Heiji , Nakazawa Masashi , Collaert Nadine , Thean Aaron 
Published: May 2016

Abstract
We investigated the effect of a thin interfacial layer (IL) made of silicon or germanium between high-k dielectrics and III–V semiconductors on the frequency dispersion of the capacitance–voltage (C–V) curves in detail. We demonstrated experimentally that the frequency dispersion at accumulation voltage is strongly dependent on the energy barrier height (ΦB) between high-k dielectrics and semiconductors. It was revealed that the improvement of frequency dispersion for n-type III–V semiconductors with IL is attributed to the increase in ΦB realized by inserting Ge IL. Moreover, the border trap density did not necessarily decrease with IL through the assessment of border trap density using a distributed bulk-oxide trap model. Finally, we proved that it is important to increase ΦB to suppress the carrier exchange and improve high-k/III–V gate stack reliability.
Application to Photocatalytic H2 Production of a Whole‐Cell Reaction by Recombinant Escherichia coli Cells Expressing [FeFe]‐Hydrogenase and Maturases Genes
Authors: Honda Yuki , Hagiwara Hidehisa , Ida Shintaro , Ishihara Tatsumi 
Published: May 2016

AbstractA photocatalytic H2 production system using an inorganic–bio hybrid photocatalyst could contribute to the efficient utilization of solar energy, but would require the development of a new approach for preparing a H2‐forming biocatalyst. In the present study, we constructed a recombinant strain of Escherichia coli expressing the genes encoding the [FeFe]‐hydrogenase and relevant maturases from Clostridium acetobutylicum NBRC 13948 for use as a biocatalyst. We investigated the direct application of a whole‐cell of the recombinant E. coli. The combination of TiO2, methylviologen, and the recombinant E. coli formed H2 under light irradiation, demonstrating that whole cells of the recombinant E. coli could be employed for photocatalytic H2 production without any time‐consuming and costly manipulations (for example, enzyme purification). This is the first report of the direct application of a whole‐cell reaction of recombinant E. coli to photocatalytic H2 production.
First Step Towards a Devil's Staircase in Spin‐Crossover Materials
Authors: Trzop Elzbieta , Zhang Daopeng , Piñeiro‐Lopez Lucia , Valverde‐Muñoz Francisco J. , Carmen Muñoz M. , Palatinus Lukas , Guerin Laurent , Cailleau Hervé , Real Jose Antonio , Collet Eric 
Published: May 2016

AbstractThe unprecedented bimetallic 2D coordination polymer {Fe[(Hg(SCN)3)2](4,4′‐bipy)2}n exhibits a thermal high‐spin (HS)↔low‐spin (LS) staircase‐like conversion characterized by a multi‐step dependence of the HS molar fraction γHS. Between the fully HS (γHS=1) and LS (γHS=0) phases, two steps associated with different ordering appear in terms of spin‐state concentration waves (SSCW). On the γHS≈0.5 step, a periodic SSCW forms with a HS‐LS‐HS‐LS sequence. On the γHS≈0.34 step, the 4D superspace crystallography structural refinement reveals an aperiodic SSCW, with a HS‐LS sequence incommensurate with the molecular lattice. The formation of these different long‐range spatially ordered structures of LS and HS states during the multi‐step spin‐crossover is discussed within the framework of “Devil's staircase”‐type transitions. Spatially modulated phases are known in various types of materials but are uniquely related to molecular HS/LS bistability in this case.
The pharmacokinetics of dronedarone in normolipidemic and hyperlipidemic rats
Authors: Jardan Yousef A. Bin , Brocks Dion R. 
Published: May 2016

AbstractThe objectives of the current study were to characterize the pharmacokinetic profile of dronedarone in the rat, and to examine the effect of hyperlipidemia on its pharmacokinetics. Single doses of dronedarone were administered to rats intravenously (4 mg/kg), orally (55 mg/kg) and intraperitoneally (65 mg/kg). To induce hyperlipidemia, some of the rats were administered intraperitoneal doses of poloxamer 407 before giving an oral dose of dronedarone. After intravenous doses of 4 mg/kg dronedarone, plasma clearance and volume of distribution at steady‐state were 25.1 ± 8.09 mL/min/kg and 10.8 ± 4.77 L/kg, respectively. After oral doses the maximum plasma concentrations (Cmax) and their median time of attainment (tmax) were 1.87 ± 1.65 mg/mL and 3.5 h, respectively. Intraperitoneal administration of 65 mg/kg dronedarone base yielded plasma Cmax and median tmax of 0.816 ± 0.611 mg/mL and 3 h, respectively. Protein binding was high in NL and HL plasma. Dronedarone is extensively distributed with high volume of distribution in the rat. The drug showed poor bioavailability (<20%) after oral and intraperitoneal administration. The increased plasma concentrations after oral dosing to hyperlipidemic rats appears to be attributable to a direct effect on metabolizing enzymes or transport proteins. Copyright © 2016 John Wiley & Sons, Ltd.
Outcomes after resection and/or radiofrequency ablation for recurrence after treatment of colorectal liver metastases
Authors: Hof J , Wertenbroek M W J L A E , Peeters P M J G , Widder J , Sieders E , de Jong K P 
Published: May 2016

Abstract

Background
Repeat liver resection for colorectal liver metastases (CRLMs) is possible in a limited number of patients, with radiofrequency ablation (RFA) as an alternative for unresectable CRLMs. The aim of this study was to analyse survival rates with these interventions.

Methods
This was a database analysis of patients who underwent first and repeat interventions for synchronous and metachronous CRLMs between 2000 and 2013. Descriptive and survival statistics were calculated.

Results
Among 431 patients who underwent resection or RFA for CRLMs, 305 patients developed recurrences for which 160 repeat interventions (resection and/or RFA or ablative radiotherapy) were performed. In total, after 707 first or repeat interventions, 516 recurrences (73·0 per cent) developed, of which 276 were retreated curatively. At the time of first intervention, independent risk factors for death were lymph node-positive primary tumour (hazard ratio (HR) 1·40; P = 0·030), more than one CRLM (HR 1·53; P = 0·007), carcinoembryonic antigen level exceeding 200 ng/ml (HR 1·89; P = 0·020) and size of largest CRLM greater than 5 cm (HR 1·54; P = 0·014). The 5-year overall survival rates for liver resection and percutaneous RFA as first intervention were 51·9 and 53 per cent, with a median overall survival of 65·0 (95 per cent c.i. 47·3 to 82·6) and 62·1 (52·2 to 72·1) months, respectively.

Conclusion
RFA had good oncological outcomes in patients with unresectable CRLMs. Radiofrequency ablation is progressively more applied with each additional intervention.
Facile Preparation of Bright‐Fluorescent Soft Materials from Small Organic Molecules
Authors: Wang Hang‐Xing , Yang Ze , Liu Zhong‐Guo , Wan Jia‐Yun , Xiao Juan , Zhang Hao‐Li 
Published: May 2016

AbstractHighly fluorescent and biocompatible soft materials are desirable for many potential applications, but their synthetic processes are somehow complicated. Herein, we have explored the feasibility of synthesis of unconventional fluorescence soft materials from small organic molecules under mild conditions. A new blue‐fluorescent soft material with high quantum yield (89.6 %) and eutectic feature prepared by simple heat treatment of citric acid (CA) and cysteine (Cys) aqueous mixtures below 100 °C in air was reported. The as‐prepared fluorescent material has the features of facile preparation, low cost, scalable production and easy to process, making it suitable for applications like fluorescent labeling and light‐emitting devices. This new finding opens a new venue for the preparation of fluorescent soft materials.
Personalized blood flow computations: A hierarchical parameter estimation framework for tuning boundary conditions
Authors: Itu Lucian , Sharma Puneet , Suciu Constantin , Moldoveanu Florin , Comaniciu Dorin 
Published: May 2016

SummaryWe propose a hierarchical parameter estimation framework for performing patient‐specific hemodynamic computations in arterial models, which use structured tree boundary conditions. A calibration problem is formulated at each stage of the hierarchical framework, which seeks the fixed point solution of a nonlinear system of equations. Common hemodynamic properties, like resistance and compliance, are estimated at the first stage in order to match the objectives given by clinical measurements of pressure and/or flow rate. The second stage estimates the parameters of the structured trees so as to match the values of the hemodynamic properties determined at the first stage. A key feature of the proposed method is that to ensure a large range of variation, two different structured tree parameters are personalized for each hemodynamic property.First, the second stage of the parameter estimation framework is evaluated based on the properties of the outlet boundary conditions in a full body arterial model: the calibration method converges for all structured trees in less than 10 iterations. Next, the proposed framework is successfully evaluated on a patient‐specific aortic model with coarctation: only six iterations are required for the computational model to be in close agreement with the clinical measurements used as objectives, and overall, there is a good agreement between the measured and computed quantities. Copyright © 2016 John Wiley & Sons, Ltd.
Central Hypoventilation in Progressive Supranuclear Palsy
Authors: Herrick Kory S. , Woltjer Randy , Pham Thao , Chalupsky Megan , Hiller Amie L. 
Published: May 2016

AbstractCentral hypoventilation, also known as Ondine's curse, results from an impairment of the autonomic respiratory drive. It is characterized by an attenuated or absent respiratory response to hypoxemia and hypercapnia with preservation of volitional respiratory function. R.J. was a 75‐year‐old woman with a diagnosis of probably PSP who developed central hypoventilation approximately 4 years after her initial onset of symptoms. Brain MRI showed no evidence of medullary lesions, one of the more common causes of adult‐onset central hypoventilation. The respiratory centers in the medulla, especially the ventral respiratory group (VRG) containing Botzinger and pre‐Botzinger complex of neurons, appear critical for normal respiratory rhythm generation. R.J. was maintained on a portable ventilator after her diagnosis of central hypoventilation. Ten months after being placed on ventilation, she passed of unclear causes. R.J. showed pathological features consistent with a diagnosis of PSP, specifically loss of neurons, secondary demyelination, and tau‐positive inclusions in both astrocytes and neurons, chiefly in the globus pallidus, midbrain, and brainstem. R.J. showed significant tauopathy in the region of the VRG in particular. We also examined this region in 16 other cases of PSP and found similar tauopathy in all but 1 case, which had significantly less involvement of this area. We had limited clinical data on these cases, but 1 had two episodes of unexplained hypoxia shortly before being placed on hospice. Central hypoventilation associated with tauopathy involving the VRG may be more common than often appreciated.
Evaluation of the Role of Umbilical Cord Serum and Autologous Serum Therapy in Reepithelialization After Keratoplasty: A Randomized Controlled Clinical Trial
Authors: Kamble Neha , Sharma Namrata , Maharana Prafulla K. , Bandivadekar Pooja , Nagpal Ritu , Agarwal Tushar , Velpandian Thirumurthy , Mittal Suneeta , Vajpayee Rasik B. 
Published: May 2016

Purpose:
To evaluate the role of umbilical cord serum (UCS) and autologous serum (AS) therapy in reepithelialization of corneal graft after keratoplasty in a randomized controlled trial.

Methods:
A total of 105 eyes with epithelial defect (ED) after keratoplasty (penetrating keratoplasty—67 and anterior lamellar keratoplasty—38) on the first postoperative day were included in the study. The eyes were randomized into three groups: UCS (n=35), AS (n=35), and artificial tears (AT) (n=35). All patients received standard postoperative medical therapy. The primary outcome measure was time to epithelialization, and secondary outcome measures were best-corrected visual acuity and graft clarity.

Results:
The ED healed completely in 103 eyes. The mean time for complete reepithelialization was 2.5±2.1, 3.1±2.2, and 4.5±1.4 days in UCS, AS, and AT groups, respectively. The mean percentage decrease in the size of the ED was significantly better in the UCS and AS groups as compared with the AT group (P=0.001). The rate of reepithelialization was comparable between the AS and UCS groups (P=0.3). On bivariate analysis, significant correlation was found between the mean size of postoperative ED, grade of the donor cornea (P=0.001), and the presence of preoperative ED (P=0.001). No complications were associated with the use of serum therapy.

Conclusion:
Most of the cases of postkeratoplasty corneal ED can be managed with AT only. The serum therapy (AS/UCS) helps in the faster reepithelialization of postkeratoplasty ED as compared with AT and may be considered as a treatment option for early epithelial healing.