bluuebunny/crossref_metadata_2025_split huggingface dataset:
Talking about tags
Authors: Clements Lucy , Liew Chern Li 
Published: March 2016

Purpose
– While examining subject headings and tags is a popular research topic, most studies focus on comparing user-assigned tags and professional subject heading. Studies that compare Library of Congress Subject Headings to user-assigned tags, for instance, dominate the literature. However, little research has involved an examination on how and to what extent these features are actually used by library staff. This study adds to the body of knowledge. This study aims to focus on how librarians perceive and use tags. By focusing on people’s perceptions rather than simply comparing social tags and formal subject headings, new insights can be collected.

Design/methodology/approach
– This research collects data through semi-structured interviews conducted with 12 library staff from various roles and locations throughout Auckland Libraries.

Findings
– The research findings show that while social tags have been adopted and used in their work by the majority of library staff interviewed, there remains resistance to using them. Some library staff preferred the traditional hierarchical subject headings found in the traditional catalogue. A general lack of awareness about tag functions and features is also evident among the staff interviewed.

Originality/value
– The research focus is unique because it examines this phenomenon in a public library setting rather than in academic libraries, an area that is rarely examined in the literature.
Brand community, loyalty and promise in myfootballclub.co.uk
Authors: Guimaraes Guilherme , Stride Chris , O'Reilly Daragh 
Published: March 2016

Purpose
– The purpose of this paper is to link the notions of brand community, loyalty and promise as a reminder to marketers of the importance to brands of keeping their commercial promises to brand community members.

Design/methodology/approach
– The paper reports on a questionnaire survey (n=500) of members of a sport brand community as part of an investigation into the relationship between brand community and brand loyalty.

Findings
– Brand loyalty was predicted by age, frequency of attendance, motivations for joining the brand community and the degree to which expectations built by the brand promise are met.

Research limitations/implications
– In common with many inquiries in the area of brand community, this is a single case study. It is primarily a cross-sectional study, with a minor longitudinal element.

Practical implications
– Branding practitioners and consultants with responsibility for brand community management issues need to balance the consumer-to-consumer dimensions of community with a careful understanding and operationalisation of the brand promise.

Originality/value
– This is the first paper to integrate the constructs of brand community and brand loyalty with that of brand promise.
Course of auditory vocal hallucinations in childhood: 11‐year follow‐up study
Authors: Bartels‐Velthuis A. A. , Wigman J. T. W. , Jenner J. A. , Bruggeman R. , van Os J. 
Published: March 2016

ObjectiveChildhood auditory vocal hallucinations (AVH) are mostly transient but may predict clinical outcomes. Little is known about their course over time and associations with risk factors, and how this may inform early intervention. Our objective was to assess the 11‐year course of AVH, associated psychopathology and risk factors.MethodA 5‐year (T1) and 11‐year (T2) follow‐up of a baseline case–control sample (n = 694, of whom 347 with AVH). At T2, online assessment of AVH, other psychotic experiences, psychopathology, trauma and cannabis use was completed by 293 adolescents aged 18–19 years.ResultsThe AVH 6‐year (T1–T2) persistence rate was 18.2%, and the AVH 11‐year (T0–T2) persistence rate was 6.2%. AVH at T2 were associated with higher levels of T2 other psychotic experiences, T2 psychopathology and T2 traumatic events, but not with T2 stress or T2 cannabis use. Persistence of AVH (i.e. AVH reported two or three times from T0) was associated with T2 traumatic events and higher risk for post‐traumatic stress disorder.ConclusionAuditory vocal hallucinations in early childhood are mostly transitory. AVH in adolescence, especially when persistent, are associated with affective symptoms and environmental risk, particularly traumatic events.
Interleukin‐22 serum levels are elevated in active scleritis
Authors: Sainz‐de‐la‐Maza Maite , Molins Blanca , Mesquida Marina , Llorenç Victor , Zarranz‐Ventura Javier , Sala‐Puigdollers Anna , Matas Jessica , Adan Alfredo , Foster C. Stephen 
Published: March 2016

AbstractPurposeTo evaluate serum cytokine profile from patients with active scleritis in a two‐centre prospective case–control study.MethodsThe serum of 20 active scleritis patients not treated with any local, periocular, or systemic immunomodulatory therapy (IMT) was analysed with multiplex assay to determine the levels of 11 cytokines interleukin (IL)‐1β, IL‐6, IL‐2, IFN‐γ, IL‐10, IL‐12p40, IL‐13, IL‐17A, IL‐5, TNF‐α, and TNF‐β, and with ELISA to determine the levels of TGF‐β1, IL‐22, and IL‐23. Twenty‐five age‐matched healthy volunteers were used as controls. In a subgroup of 13 patients with active disease, a second serum sample was obtained when the disease was inactive and levels of IL‐22 were determined. Serum IL‐22 levels from patients with active scleritis were correlated with type of scleritis (non‐necrotizing and necrotizing), degree of inflammation (0–4+ :≤2+ and >2+), and associated systemic disease.ResultsSerum levels of IL‐22 were elevated in active scleritis patients compared to controls (6.41 ± 1.52 pg/ml versus 1.93 ± 0.39 pg/ml, p = 0.012) and significantly decreased after scleritis remission with the use of IMT (p = 0.005). There was no statistical association with scleritis type, degree of inflammation, or associated systemic disease. The serum levels of other cytokines were not significantly different from controls.ConclusionIn our study cohort, IL‐22 serum levels were significantly elevated in active scleritis patients compared to controls and decreased significantly after remission. Our results suggest that IL‐22, a T helper (Th) 17‐ and Th22‐ derived cytokine, may play a critical role in the physiopathology of scleritis.
Bortezomib in the treatment of refractory thrombotic thrombocytopenic purpura
Authors: Patriquin Christopher J. , Thomas Mari R. , Dutt Tina , McGuckin Siobhan , Blombery Piers A. , Cranfield Tanya , Westwood John P. , Scully Marie 
Published: March 2016

SummaryAcquired thrombotic thrombocytopenic purpura (TTP) is a rare, life‐threatening condition caused by autoantibody‐mediated inhibition of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type‐1 motif, 13). Therapeutic plasma exchange (TPE) improves survival, but disease may be refractory despite therapy. Management and treatment response of refractory TTP is variable, with rituximab and other immunosuppression often being used. Case reports have suggested a benefit of the proteasome inhibitor, bortezomib, possibly due to elimination of the autoreactive plasma cells producing anti‐ADAMTS13 antibodies. We evaluated the effect of bortezomib in a series of primary refractory TTP patients unresponsive to intensive therapy. Bortezomib‐treated patients were identified from consecutive cases managed at two UK referral centres. Demographic and clinical data were extracted from hospital records. ADAMTS13 activity was measured using a fluorescence resonance energy transfer VWF73 assay, and anti‐ADAMTS13 IgG using enzyme‐linked immunosorbent asssay. We identified six bortezomib‐treated patients out of 51 consecutive cases of acute, acquired TTP. All patients received TPE, methylprednisolone and rituximab. Five of the six achieved complete remission with bortezomib, and one died of cardiac arrest due to underlying disease. No treatment‐related adverse events were observed. Mean follow‐up time after hospital discharge was 17 months (range: 3–33). Bortezomib appears effective in the treatment of a subgroup of cases with severe, refractory TTP. Prospective trials are required to further investigate this effect.
Évolution du contrôle et de la confiance dans un PPP international
Authors: Skander Dorra , Préfontaine Lise 
Published: March 2016

AbstractThis article reviews the evolution of control mechanisms and trust types that promote cooperation within the PPP strategies adopted at the international level. One case of international PPP is examined from the negotiated order perspective; the results show all the importance of partnership capacity to make such hybrid strategies both a tremendous financial success and a successful instance of the partnership process. Throughout the cycle of partnership in such international projects, we see the emergence of three types of trust (institutional, inter‐organizational and inter‐personal), and two types of control (formal and social) that co‐exist, are complementary and can be substituted in establishing the safeguards of partnership capacity among parties of the project.
Early childhood education and care reform in Canadian provinces: Understanding the role of experts and evidence in policy change
Authors: A. White Linda , Prentice Susan 
Published: March 2016

AbstractIn over half of Canada's provinces, a recent commission has recommended major reform of ECEC systems; in response, provincial governments in nearly all cases have chosen to implement full‐day kindergarten funded by the province and delivered through public schools. We analyze the commission processes that led to changes to investigate the relationship between experts, policy makers, and policy outcomes. Our analysis of processes in BC, Alberta, Ontario, Quebec, and PEI leads us to conclude that governments rarely fully implement the programs supported by the evidence base and recommended by their own experts. Instead, recent policy changes have been driven by a highly selective and path‐dependent approach to the complex issue of early childhood care and education.
Measuring parentage policy in the Canadian provinces: A comparative framework
Authors: Snow Dave 
Published: March 2016

AbstractThis paper develops a framework to measure parentage policy based on the legal barriers faced by intended parents, taking into account eligibility requirements, rules for genetic relationships, and surrogacy contract enforceability. It then applies this framework to the Canadian provinces. While parentage policy in Canada is undoubtedly a patchwork, policy change has moved in an increasingly permissive direction, often as a result of litigation. Moreover, this study provides an opportunity to develop broader research project for comparative scholars of parentage policy. Future studies of parentage policy, building from the framework developed here, should qualitatively examine the role of policy implementers other than legislatures and determine how policy learning and transfer affect parentage policy change. Because parentage policy can provide legal certainty for parents and prevent legal disputes, understanding the factors behind policy change is an endeavour with both theoretical and practical significance.
The avidity of PR3-ANCA in patients with granulomatosis with polyangiitis during follow-up
Authors: Kemna M J , Schlumberger W , van Paassen P , Dähnrich C , Damoiseaux J G M C , Cohen Tervaert J W 
Published: March 2016

SummaryThe objective of this study is to investigate whether the avidity of proteinase-3-anti-neutrophil cytoplasmic antibody (PR3-ANCA) changes during follow-up in different subgroups of patients with granulomatosis with polyangiitis (GPA). We selected 10 patients with renal relapsing GPA, 10 patients with renal non-relapsing GPA and 10 patients with non-renal relapsing GPA. In all patients, an ANCA rise occurred during remission. The avidity was measured using a chaotropic approach at the time of an ANCA rise and at the time of a relapse in relapsing patients or time-matched during remission in non-relapsing patients. No difference was observed in the avidity at the ANCA rise between renal relapsing patients [26·2% (15·5–47·5)], renal patients without a relapse [39·6% (21·2–63·4)] and non-renal relapsing patients [34·2% (21·6–59·5)]. In renal relapsing patients, the avidity increased significantly from the moment of the ANCA rise to the relapse [difference 6·4% (0·0–17·1), P = 0·0273]. The avidity did not increase after an ANCA rise in renal non-relapsing patients [difference 3·5 (−6·0 to 10·1), P = 0·6250] or in non-renal relapsing patients [difference −3·1% (−8·0 to 5·0), P = 0·5703]. The avidity of PR3-ANCA increases after an ANCA rise during follow-up in renal relapsing patients, but not after an ANCA rise in renal patients who remain in remission or in non-renal relapsing patients.
Review of the ophthalmic manifestations of gout and uric acid crystal deposition
Authors: Ao Jack , Goldblatt Fiona , Casson Robert J 
Published: March 2016

AbstractGout is a clinical disorder that is characterized by the deposition of monosodium urate crystals (MSU) in joints and tendons, usually in the presence of prolonged hyperuricaemia. Following an asymptomatic phase of hyperuricaemia, gout usually presents as acute monoarthritis followed by periods of remission and exacerbation. Conjunctival hyperaemia and subconjunctival haemorrhage exacerbated by purine intake are two of the more common manifestations that may go unrecognized. Other ocular and adnexal structures can be affected by urate crystal deposition and associated inflammation, with potentially vision‐threatening consequences; however, ocular manifestations of gout are rare and may have been over‐reported in the older literature, but our understanding of the clinic‐pathological features of ocular urate deposits remains limited.
Long‐termEEGin patients with the ring chromosome 20 epilepsy syndrome
Authors: Freire de Moura Maria , Flores‐Guevara Roberto , Gueguen Bernard , Biraben Arnaud , Renault Francis 
Published: March 2016

SummaryThe recognizable electroencephalography (EEG) pattern of ring chromosome 20 epilepsy syndrome can be missing in patients with r(20) chromosomal anomaly, and may be found in patients with frontal lobe epilepsy of other origin. This study aims to search for more specificEEGsigns by using long‐term recordings and measuring the duration of paroxysmal anomalies. The series included 12 adult patients with r(20) anomaly, and 12 controls without any chromosomal aberration. We measured the duration of every paroxysmal burst and calculated the sum of their durations for each long‐termEEGrecording. We compared patients to controls using the Mann‐WhitneyU‐test. Every patient showed long‐lasting paroxysmalEEGbursts, up to 60 min; controls did not show any bursts longer than 60 s (p < 0.0001). The total duration of paroxysmal anomalies was significantly longer in patients (31–692 min) compared to controls (0–48 min) (p < 0.0001). Thus, long‐term recordings enhance the contribution ofEEGmethods for characterizing the ring 20 chromosome epilepsy syndrome.
Random subspace method with class separability weighting
Authors: Mert Ahmet , Kılıç Niyazi , Bilgili Erdem 
Published: March 2016

AbstractThe random subspace method (RSM) is one of the ensemble learning algorithms widely used in pattern classification applications. RSM has the advantages of small error rate and improved noise insensitivity due to ensemble construction of the base‐learners. However, randomness may cause a reduction of the final ensemble decision performance because of contributions of classifiers trained by subsets with low class separability. In this study, we present a new and improved version of the RSM by introducing a weighting factor into the combination phase. One of the class separability criteria, J3, is used as a weighting factor to improve the classification performance and eliminate the drawbacks of the standard RSM algorithm. The randomly selected subsets are quantified by computing their J3 measure to determine voting weights in the model combination phase, assigning lower voting weight to classifiers trained by subsets with poor class separability. Two models are presented including J3‐weighted RSM and optimized J3 weighted RSM. In J3 weighted RSM, computed weighting values are directly multiplied by class assignment posteriors, whereas in optimized J3 weighted RSM, computed weighting values are optimized by a pattern search algorithm before multiplying by posteriors. Both models are shown to provide better error rates at lower subset dimensionality.
Crystal structure and interaction studies of the human FBxo3 ApaG domain
Authors: Krzysiak Troy C. , Chen Bill B. , Lear Travis , Mallampalli Rama K. , Gronenborn Angela M. 
Published: March 2016

Transcriptional activation of proinflammatory cytokines, mediated by tumor necrosis factor receptor‐associated factors (TRAFs), is in part triggered by the degradation of the F‐box protein, FBxl2, via an E3 ligase that contains another F‐box protein, FBxo3. The ApaG domain of FBxo3 is required for the interaction with and degradation of FBxl2 [Mallampalli RK et al., (2013) J Immunol 191, 5247–5255]. Here, we report the X‐ray structure of the human FBxo3 ApaG domain, residues 278–407, at 2.0 Å resolution. Like bacterial ApaG proteins, this domain is characterized by a classic Immunoglobin/Fibronectin III‐type fold, comprising a seven‐stranded β‐sheet core, surrounded by four extended loops. Although cation binding had been proposed for bacterial ApaG proteins, no interactions with Mg2+ or Co2+ were detected for the human ApaG domain. In addition, dinucleotide polyphosphates, which have been reported to be second messengers in the inflammation response and targets of the bacterial apaG‐containing operon, are not bound by the human ApaG domain. In the context of the full‐length protein, loop 1, comprising residues 294–303, is critical for the interaction with FBxl2. However, titration of the individual ApaG domain with a 15‐mer FBxl2 peptide that was phosphorylated on the crucial T404, as well as the inability of the ApaG domain to interact with full‐length FBxl2, assessed by coimmunoprecipitation, indicate that the ApaG domain alone is necessary, but not sufficient for binding and degradation of FBxl2.DatabasePDB ID (5HDW).
Dynamic responses of nitrous oxide emission and nitrogen use efficiency to nitrogen and biochar amendment in an intensified vegetable field in southeastern China
Authors: Li Bo , Bi Zhichao , Xiong Zhengqin 
Published: March 2016

AbstractIntensive vegetable production exhibits contrasting characteristics of high nitrous oxide (N2O) emissions and low nitrogen use efficiency (NUE). In an effort to mitigate N2O emissions and improve NUE, a field experiment with nine consecutive vegetable crops was designed to study the combined effects of nitrogen (N) and biochar amendment and their interaction on soil properties, N2O emission and NUE in an intensified vegetable field in southeastern China. We found that N application significantly increased N2O emissions, N2O–N emission factors and yield‐scaled N2O emissions by 51–159%, 9–125% and 14–131%, respectively. Moreover, high N input significantly decreased N partial factor productivity (PFPN) and even yield during the seventh to ninth vegetable crops along with obvious soil degradation and mineral N accumulation. To the contrary, biochar amendment resulted in significant decreases in cumulative N2O emissions, N2O–N emission factor and yield‐scaled N2O emissions by 5–39%, 16–67% and 14–53%, respectively. In addition, biochar significantly increased yield, PFPN and apparent recovery of N (ARN). Although without obvious influence during the first to fourth vegetable crops, biochar amendment mitigated N2O emissions during the fifth to ninth vegetable crops. The relative effects of biochar amendments were reduced with increasing N application rate. Hence, while high N input produced adverse consequences such as mineral N accumulation and soil degradation in the vegetable field, biochar amendment can be a beneficial agricultural strategy to mitigate N2O emissions and improve NUE and soil quality in vegetable field.
A subset of ectomesenchymal chondromyxoid tumours of the tongue show EWSR1 rearrangements and are genetically linked to soft tissue myoepithelial neoplasms: a study of 11 cases
Authors: Argyris Prokopios P , Bilodeau Elizabeth A , Yancoskie Aaron E , Trochesset Denise , Pambuccian Stefan E , Wetzel Stephanie L , Shah Sonal S , Edelman Morris , Freedman Paul , Dolan Michelle , Koutlas Ioannis G 
Published: March 2016

AimsEctomesenchymal chondromyxoid tumour (ECT) is a rare, benign intraoral neoplasm showing a predilection for the anterior dorsum of the tongue. The World Health Organization includes ECT in the pathological spectrum of soft tissue myoepithelioma. EWS RNA‐binding protein 1 gene (EWSR1) rearrangement is found in 45% of cutaneous, soft tissue and bone myoepithelial neoplasms, and pleomorphic adenoma gene 1 (PLAG1) aberrations are found in 37% of EWSR1‐negative soft tissue myoepitheliomas. The aim of this study was to evaluate the presence of EWSR1 and PLAG1 rearrangements in ECTs.Methods and resultsEleven formalin‐fixed, paraffin‐embedded ECTs were evaluated with fluorescence in‐situ hybridization probes for EWSR1 (22q12) and PLAG1 (8q12). Among the 11 ECTs tested, three (27.3%) showed EWSR1 rearrangement in >15% of tumour cells, whereas eight (72.7%) cases did not show EWSR1 rearrangement. Eight of nine (89%) ECTs showed gain of EWSR1, probably representing gain of all or part of chromosome 22, in a varying proportion of neoplastic cells ranging between 1.4% and 27.9%. PLAG1 rearrangement was not detected in the successfully hybridized tissue sections (7/11). No correlation was observed between the molecular and histopathological findings, such as morphology of the neoplastic cells, the presence of atypia, and matrical type.ConclusionsWe identified EWSR1 rearrangement in >25% of ECTs. These results suggest that some ECTs are at least genetically related to myoepithelioma of the soft parts. Finally, PLAG1 aberrations do not appear to be critical in the pathogenesis of ECT of the tongue.
The impact of intensive care in a private hospital on patients aged 80 and over: health‐related quality of life, functional status and burden versus benefit
Authors: Levinson M. , Mills A. , Oldroyd J. , Gellie A. , Barrett J. , Staples M. , Stephenson G. 
Published: March 2016

BackgroundGreater numbers of persons aged over 80 years are admitted to intensive care units (ICU) compared with 15 years ago. Outcomes other than death such as physical dependence and cognitive impairment and treatment burden are important to older people.AimsThe aims of this study were to determine the long‐term outcomes of functional impairment, health‐related quality of life (HRQoL) and the self‐reported burden of treatment in a sample of patients aged 80 years and above admitted to ICU. Half of the cohort were admitted for elective cardiac surgery, the rest for non‐cardiac surgery and medical conditions.MethodsIn this longitudinal cohort study, in a tertiary level ICU, we measured HRQoL using the SF‐36 and functional status using the modified Barthel Index at several time points over a 2‐year follow‐up period. We also assessed treatment burden by asking participants whether they thought the episode of care was worthwhile.ResultsA total of 348 patients was recruited into the study. One‐fifth of the cohort had died by the 2‐year follow‐up data collection point. There was an improvement in physical functioning in the cardiac surgery group at 6 months which was not sustained. There was no change in HRQoL at 2 years in either group. The majority valued the episode of care.ConclusionWe demonstrated that HRQoL and previous lifestyle is preserved in the majority following ICU admission, associated with a high level of patient valuation of the episode of care.