bluuebunny/crossref_metadata_2025_split huggingface dataset:
Worldwide organization and structures for kidney transplantation services
Authors: Viecelli Andrea K , Gately Ryan , Barday Zunaid , Shojai Soroush , Arruebo Silvia , Caskey Fergus J , Damster Sandrine , Donner Jo-Ann , Jha Vivekanand , Levin Adeera , Nangaku Masaomi , Saad Syed , Tonelli Marcello , Ye Feng , Okpechi Ikechi G , Bello Aminu K , Johnson David W 
Published: September 2024

ABSTRACT

Background
Kidney transplantation (KT) is the preferred modality of kidney replacement therapy with better patient outcomes and quality of life compared with dialytic therapies. This study aims to evaluate the epidemiology, accessibility and availability of KT services in countries and regions around the world.

Methods
This study relied on data from an international survey of relevant stakeholders (clinicians, policymakers and patient advocates) from countries affiliated with the International Society of Nephrology that was conducted from July to September 2022. Survey questions related to the availability, access, donor type and cost of KT.

Results
In total, 167 countries responded to the survey. KT services were available in 70% of all countries, including 86% of high-income countries, but only 21% of low-income countries. In 80% of countries, access to KT was greater in adults than in children. The median global prevalence of KT was 279.0 [interquartile range (IQR) 58.0–492.0] per million people (pmp) and the median global incidence was 12.2 (IQR 3.0–27.8) pmp. Pre-emptive KT remained exclusive to high- and upper-middle-income countries, and living donor KT was the only available modality for KT in low-income countries. The median cost of the first year of KT was $26 903 USD and varied 1000-fold between the most and least expensive countries.

Conclusion
The availability, access and affordability of KT services, especially in low-income countries, remain limited. There is an exigent need to identify strategies to ensure equitable access to KT services for people with kidney failure worldwide, especially in the low-income countries.
Integration of zinc anode and cement: unlocking scalable energy storage
Authors: Liu Zhaolong , Feng Pan , Liu Ruidan , Yuan Long , Meng Xiangyu , Tao Guanghui , Chen Jian , Ran Qianping , Hong Jinxiang , Liu Jiaping , Miao Changwen 
Published: September 2024

ABSTRACT
The significant volume of existing buildings and ongoing annual construction of infrastructure underscore the vast potential for integrating large-scale energy-storage solutions into these structures. Herein, we propose an innovative approach for developing structural and scalable energy-storage systems by integrating safe and cost-effective zinc-ion hybrid supercapacitors into cement mortar, which is the predominant material used for structural purposes. By performing air entrainment and leveraging the adverse reaction of the ZnSO4 electrolyte, we can engineer an aerated cement mortar with a multiscale pore structure that exhibits dual functionality: effective ion conductivity in the form of a cell separator and a robust load-bearing capacity that contributes to structural integrity. Consequently, a hybrid supercapacitor building block consisting of a tailored cement mortar, zinc metal anode and active carbon cathode demonstrates exceptional specific energy density (71.4 Wh kg−1 at 68.7 W kg−1), high areal energy density (2.0 Wh m−2 at 1.9 W m−2), favorable cycling stability (∼92% capacity retention after 1000 cycles) and exceptional safety (endurance in a 1-hour combustion test). By demonstrating the scalability of the structural energy-storage system coupled with solar energy generation, this new device exhibits great potential to revolutionize energy-storage systems.
Epidemiology of Campylobacter Species Infection in Kidney Transplant Recipients: A Retrospective Multicentric Case-Control Study in France
Authors: Bos Feline , Gueneau Romain , Crepin Thomas , Tinévez Claire , Taton Benjamin , Couzi Lionel , Moreau Karine , Schvartz Betoul , Perrin Peggy , Gatault Philippe , Scemla Anne , Chatelet-Pouliquen Valérie , Levi Charlène , Kamar Nassim , Lanternier Fanny , Lanotte Philippe , Neau Didier , Merville Pierre , Lehours Philippe , Puges Mathilde , Kaminski Hannah 
Published: September 2024

Abstract

Background
Campylobacteriosis in kidney transplant recipients (KTRs) is the most common identified bacterial cause of diarrhea. Risk factors in KTRs are unknown.

Methods
A 10-year multicentric, retrospective 1:1 case-control study was performed in France between 2010 and 2020. The main aim was to identify factors associated with Campylobacter-related infection in KTRs. The KTRs with a functional graft and campylobacteriosis (positive stool culture and/or blood culture and/or positive nucleic amplification test) and their controls matched on transplantation date within the same center were included.

Results
We identified 326 patients with campylobacteriosis. The estimated incidence rate of campylobacteriosis was 2.3/1000 patient-years. The infection occurred at a median of 2.4 years posttransplantation. The independent risk factors for campylobacteriosis were use of corticosteroids as maintenance regimen (75.8% vs 66%; P &lt; .001), acute rejection (8.9% vs 4%; P = .048), low lymphocyte count (0.96 vs 1.4 giga/liter (G/L); P &lt; .001), and low basal estimated glomerular filtration rate (eGFR) (44.2 vs 57.5 mL/minute/1.73 m2; P &lt; .001). A fluoroquinolone was initiated in 64 (21.4%) patients, with 51.1% of antimicrobial resistance, whereas almost all strains were erythromycin sensitive.

Conclusions
Campylobacteriosis has a higher incidence in the 2 first years of transplantation. The factors independently associated with campylobacteriosis are corticosteroids as maintenance immunosuppressive regimen, low lymphocyte counts, low eGFR, and a history of acute rejection. Due to high antimicrobial resistance with fluoroquinolone, the first line of treatment should be azithromycin.
The MdIAA29-MdARF4 complex plays an important role in balancing plant height with salt and drought stress responses
Authors: Lei Yingying , Chen Cui , Chen Wenjun , Dai Hongyan 
Published: September 2024

Abstract
Breeding dwarf apple (Malus domestica) varieties is a recent trend in agriculture because such varieties are easy to maintain and have high yields; however, dwarf apple trees generally have poor stress tolerance. Balancing apple plant height and stress response has been an important breeding goal. In this study, aux/indole-3-acetic acid 29 gene in apple (MdIAA29) overexpression lines (#1, #2, and #3) had reduced plant height by 39%, 31%, and 35%, respectively, suitable for close planting applications. Surprisingly, the dwarf MdIAA29-overexpressing lines also showed increased plant tolerance to salt and drought stresses. Further analysis showed that MdIAA29 inhibited the regulation of auxin response factor 4 (ARF4) on Gretchen Hagen 3.9 (GH3.9) gene and 9-cis-epoxycarotenoid dioxygenase 3 (NCED3) gene in apple and changed the contents of auxin and abscisic acid in different tissues, thus achieving a balance between plant height and stress tolerance. In addition, we also found that MdIAA7 enhanced the inhibitory effect of MdIAA29 on MdARF4. In brief, the MdIAA29-MdARF4 complex significantly impacts the height of apple plants and their ability to respond to salt and drought stress.
Frontloaded Home Health Physical Therapy Reduces Hospital Readmissions Among Medicare Fee-for-Service Beneficiaries
Authors: McLaughlin Kevin H , Levy Joseph F , Reiff Jenni S , Burgdorf Julia , Reider Lisa 
Published: September 2024

Abstract

Objective
The purpose of this paper is to determine a claims-based definition of frontloaded home health physical therapy (HHPT) and examine the effect of frontloaded HHPT visits on all-cause 30-day hospital readmissions.

Methods
This study used a retrospective analysis of Medicare fee-for-service claims from older adults (≥65 years) in the National Health and Aging Trends Study (2011–2017) with ≥1 HHPT visit within 30 days of a hospitalization (n = 1344 hospitalizations; weighted n = 7,727,384). An exploratory analysis of home health claim distribution was conducted to determine definitions of frontloaded HHPT. Generalized linear models were then used to examine the relationship between hospital readmission and each definition of frontloading.

Results
Four definitions of frontloaded HHPT were identified: ≥2 HHPT visits in the first week after discharge; ≥3 visits in the first week; ≥4 visits in the first 2 weeks; and ≥ 5 visits in the first 2 weeks. The adjusted risk of readmission was lower for older adults receiving frontloaded HHPT in the first week: (risk ratio [RR] for ≥2 vs &lt;2 visits = 0.57; 95% CI = 0.41–0.79; RR for ≥3 vs &lt;3 visits = 0.39; 95% CI = 0.22–0.72). The reduction in risk of readmission was even greater for older adults receiving ≥4 versus &lt;4 HHPT visits (RR = 0.32; 95% CI = 0.21–0.48) and ≥ 5 versus &lt;5 HHPT visits (RR = 0.27; 95% CI = 0.14–0.50) within the first 2 weeks. The effect of HHPT frontloading was greater for patients hospitalized with surgical versus medical diagnoses and for patients with diagnoses targeted by the Hospital Readmissions Reduction Program.

Conclusion
Frontloaded HHPT reduces 30-day hospital readmissions among Medicare beneficiaries. Additional research is needed to determine the optimal number of visits and those most likely to benefit from frontloaded HHPT.

Impact
Frontloaded HHPT can be an effective approach for reducing 30-day hospital readmissions among Medicare beneficiaries.

Lay Summary
This study found that providing home health physical therapist visits early and often after hospital discharge decreases the risk that patients will be readmitted over the next 30 days.
Sumsets in the set of squares
Authors: Elsholtz Christian , Wurzinger Lena 
Published: September 2024

Abstract
We study sumsets $\mathcal{A}+\mathcal{B}$ in the set of squares $\mathcal{S}$ (and, more generally, in the set of kth powers $\mathcal{S}_k$, where $k\geq 2$ is an integer). It is known by a result of Gyarmati that $\mathcal{A}+\mathcal{B}\subset \mathcal{S}_k \cap [1,N]$ implies that $\min(|\mathcal{A}|,|\mathcal{B}|)=O_k(\log N)$. Here, we study how the upper bound on $|\mathcal{B}|$ decreases, when the size of $|\mathcal{A}|$ increases (or vice versa). In particular, if $|\mathcal{A}|\geq C k^{\frac{1}{m}} m (\log N)^{\frac{1}{m}}$, then $|\mathcal{B}|=O_k(m^2 \log N)$, for sufficiently large N, a positive integer m and an explicit constant C &gt; 0. For example, with $m\sim \log \log N$ this gives: If $|\mathcal{A}|\geq C_k \log \log N$, then $|\mathcal{B}|=O_k(\log N (\log \log N)^2)$.
Real-world data on tolerability of COVID-19 vaccination in patients with rheumatoid arthritis based on patient-reported outcomes
Authors: Feuchtenberger Martin , Kovacs Magdolna Szilvia , Eder Anna , Nigg Axel , Almanzar Giovanni , Prelog Martina , Schäfer Arne 
Published: September 2024

Abstract

Objectives
To assess tolerability of COVID-19 vaccination in patients with RA and controls based on patient-reported outcomes (PROs).

Methods
In total, 266 study participants were included at 6 ± 1 weeks after their second vaccination (BioNTech/Pfizer (72.2%), AstraZeneca (18.8%) and Moderna (9.0%)). In a cross-sectional, observational study design, PRO data were recorded regarding both total and symptom-level tolerability.

Results
Overall tolerability was very high according to the patients’ self-assessment scores (1.71 for the first and 1.72 for the second vaccination, 6-point Likert scale [1 (very good) to 6 (very poor)]) and did not differ significantly between patients with RA (n = 204) and controls (n = 62). Self-rated overall tolerability regarding first vaccination was significantly better (P = 0.002) in patients receiving mRNA vaccines (n = 193, mean tolerability 1.59) as compared with vector-vaccinated patients (n = 73, mean tolerability 2.04). Homologous or heterologous vaccination regimens had no statistically significant effect on vaccine tolerability (P = 0.131). Reservations about the vaccination were rare (6.4% for the first and 6.0% for the second vaccination) but significantly associated with poorer overall tolerability (P &lt; 0.001) and significantly reduced willingness to recommend vaccination to others (P &lt; 0.001 for the first and P = 0.004 for the second vaccination).

Conclusion
Based on these real-world data, tolerability of COVID-19 vaccination was very good in both RA patients and controls. Reservations against COVID-19 vaccination were rare overall, but if present, associated with a significantly worse tolerability and a significantly lower degree of recommendation.
Machine Learning for Continuous-Time Finance
Authors: Duarte Victor , Duarte Diogo , Silva Dejanir H 
Published: September 2024

Abstract
We develop an algorithm for solving a large class of nonlinear high-dimensional continuous-time models in finance. We approximate value and policy functions using deep learning and show that a combination of automatic differentiation and Ito’s lemma allows for the computation of exact expectations, resulting in a negligible computational cost that is independent of the number of state variables. We illustrate the applicability of our method to problems in asset pricing, corporate finance, and portfolio choice and show that the ability to solve high-dimensional problems allows us to derive new economic insights.
Credit Cycles, Expectations, and Corporate Investment
Authors: Gulen Huseyin , Ion Mihai , Jens Candace E , Rossi Stefano 
Published: September 2024

Abstract
We provide a systematic empirical assessment of the Minsky hypothesis that business fluctuations stem from irrational swings in expectations. Using predictable firm-level forecast errors, we build an aggregate index of irrational expectations and use it to provide three sets of results. First, we show that our index predicts aggregate credit cycles. Next, we show that these predictable credit cycles drive cycles in firm-level debt issuance and investment and similar cycles between financially constrained and unconstrained firms, as Minsky predicts. Finally, we show more pronounced cycles in firm-level financing and investment for firms with ex ante more optimistic expectations. (JEL G31, G32, G40, E32, E44)
Horizon-Dependent Risk Aversion and the Timing and Pricing of Uncertainty
Authors: Andries Marianne , Eisenbach Thomas M , Schmalz Martin C 
Published: September 2024

Abstract
Inspired by experimental evidence, we amend the recursive utility model to let risk aversion decrease with the temporal horizon. Our pseudo-recursive preferences remain tractable and retain appealing features of the long-run risk framework, notably its success at explaining asset pricing moments. In addition, our model addresses two challenges to the standard model. Calibrating the agents’ preferences to explain the equity premium no longer implies an extreme preference for early resolutions of uncertainty. Horizon-dependent risk aversion helps resolve key puzzles in finance on the valuation of assets across maturities and captures the term structure of equity risk premiums and its dynamics.
Revisiting MSS v. Belgium and Greece and Interim Measures before the European Court of Human Rights
Authors: Isa Daniel Victoria Oluwatobi , Ní Ghráinne Brid 
Published: September 2024

ABSTRACT
This article examines the 2011 European Court of Human Rights judgment in MSS v. Belgium and Greece, which held that transferring an asylum applicant from Belgium to Greece violated the European Convention on Human Rights. Despite receiving praise for reaffirming state obligations, this article challenges the verdict. It argues that in MSS, the Court of Human Rights missed a crucial opportunity, leaving the applicant exposed to nearly two and a half years of hardship in Greece, rendering his final triumph before the Court insignificant. The article reimagines the case, envisioning the Court granting an interim measure to halt the transfer. The proposed alternative conclusion, which prioritises the applicant’s best interests, could result in substantial political and policy implications. The purpose of this article is to highlight the importance of interim measures in protecting migrants’ rights and to encourage the Court to employ them more frequently.
The global evolution and impact of systems biology and artificial intelligence in stem cell research and therapeutics development: a scoping review
Authors: Silva-Sousa Thayna , Usuda Júlia Nakanishi , Al-Arawe Nada , Frias Francisca , Hinterseher Irene , Catar Rusan , Luecht Christian , Riesner Katarina , Hackel Alexander , Schimke Lena F , Dias Haroldo Dutra , Filgueiras Igor Salerno , Nakaya Helder I , Camara Niels Olsen Saraiva , Fischer Stefan , Riemekasten Gabriela , Ringdén Olle , Penack Olaf , Winkler Tobias , Duda Georg , Fonseca Dennyson Leandro M , Cabral-Marques Otávio , Moll Guido 
Published: September 2024

Abstract
Advanced bioinformatics analysis, such as systems biology (SysBio) and artificial intelligence (AI) approaches, including machine learning (ML) and deep learning (DL), is increasingly present in stem cell (SC) research. An approximate timeline on these developments and their global impact is still lacking. We conducted a scoping review on the contribution of SysBio and AI analysis to SC research and therapy development based on literature published in PubMed between 2000 and 2024. We identified an 8 to 10-fold increase in research output related to all 3 search terms between 2000 and 2021, with a 10-fold increase in AI-related production since 2010. Use of SysBio and AI still predominates in preclinical basic research with increasing use in clinically oriented translational medicine since 2010. SysBio- and AI-related research was found all over the globe, with SysBio output led by the (US, n = 1487), (UK, n = 1094), Germany (n = 355), The Netherlands (n = 339), Russia (n = 215), and France (n = 149), while for AI-related research the US (n = 853) and UK (n = 258) take a strong lead, followed by Switzerland (n = 69), The Netherlands (n = 37), and Germany (n = 19). The US and UK are most active in SCs publications related to AI/ML and AI/DL. The prominent use of SysBio in ESC research was recently overtaken by prominent use of AI in iPSC and MSC research. This study reveals the global evolution and growing intersection among AI, SysBio, and SC research over the past 2 decades, with substantial growth in all 3 fields and exponential increases in AI-related research in the past decade.
Glycemic Control and Risk of Congenital Malformations in Women With Type 1 Diabetes
Authors: Thorius Ida Holte , Petersen Janne , Husemoen Lise Lotte N. , Alibegovic Amra C. , Gall Mari-Anne , Damm Peter , Mathiesen Elisabeth R. 
Published: September 2024

OBJECTIVE:
To investigate the association between maternal glycemic control and the risk of congenital malformations in offspring of women with type 1 diabetes and to examine whether there is a hemoglobin A1C (Hb A1C) threshold value at which the risk for malformations increases significantly.

METHODS:
Analyses were performed on data from a multinational, observational cohort of 1,908 liveborn offspring of women with type 1 diabetes recruited in early pregnancy from 17 countries between 2013 and 2018. Offspring with malformations were identified according to European Surveillance of Congenital Anomalies version 1.4 and categorized as having one or more major malformations or minor malformations exclusively. The association between first-trimester Hb A1C levels and the risk of congenital malformations was investigated with splines in crude and adjusted logistic regression models.

RESULTS:
In total, 11.9% of the offspring (n=227) of women with type 1 diabetes had congenital malformations, including 2.1% (n=40) with at least one severe malformation. Women giving birth to offspring with malformations had a higher prevalence of psychiatric disorders (13.2% vs 7.2%, P<.01), thyroid disorders (33.0% vs 26.7%, P<.05), and folic acid supplementation (87.1% vs 77.7%, P<.01). The Hb A1C levels in the first trimester were similar (median 6.8% [interquartile range 6.3–7.6%] vs 6.7% [6.2–7.6%], P=.13) compared with women giving birth to offspring without malformations. The spline analysis illustrated a curvilinear association between Hb A1C levels and the risk of malformations with no clear threshold values. Higher first-trimester Hb A1C levels were associated with an increased risk of malformations (crude odds ratio [OR] 1.13, 95% CI, 1.01–1.27, adjusted odds ratio [aOR] 1.29, 95% CI, 1.10–1.51) and major malformations (crude OR 1.49, 95% CI, 1.23–1.81, aOR 1.57, 95% CI, 1.15–2.09).

CONCLUSION:
An increased risk for congenital malformations was curvilinearly associated with higher Hb A1C levels in early pregnancy among women with type 1 diabetes without any threshold values identified.

CLINICAL TRIAL REGISTRATION:

ClinicalTrials.gov, NCT01892319.
Validation of Sagittal age-adjusted Score in Predicting Proximal Junctional Kyphosis/Failure and Clinical Outcomes Following Adult Spinal Deformity Surgery
Authors: Park Se-Jun , Park Jin-Sung , Kang Dong-Ho , Jung Kyung-Hun , Kang Min-Wook , Jung Choong-Won , Kim Hyun-Jun , Lee Chong-Suh 
Published: September 2024

Study Design.
Retrospective study

Objectives.
To validate the sagittal age-adjusted score (SAAS) in predicting proximal junctional kyphosis/failure (PJK/F) and good clinical outcomes following adult spinal deformity (ASD) surgery.

Summary of Background Data.
SAAS is a relatively new assessment system that incorporates age-adjusted sagittal parameters of pelvic incidence (PI) - lumbar lordosis (LL), pelvic tilt (PT), and T1 pelvic angle (TPA) to predict the PJK/F. External validation is required to verify its clinical usefulness.

Methods.
We included patients with ASD undergoing ≥5-level fusion including the sacrum or pelvis. SAAS was calculated based on the scores of the three components: PI-LL, PT, and TPA. PJK/F rates and clinical outcomes were compared among the correction categories (undercorrection, matched correction, and overcorrection) for the SAAS as well as for each of the three components. PJK/F rates were compared according to the correction groups of the sagittal components and total SAAS using the chi-square test. Receiver operating characteristic (ROC) analysis was performed to evaluate the predictive ability of overcorrection to develop PJK/F for the three sagittal parameters and SAAS. PROMs at final follow-up were compared among correction groups using ANOVA with Bonferroni post-hoc corrections.

Results.
A total 411 patients were included in the study (mean age: 69.3 y, mean body mass index: 25.9 kg/m2, total levels fused: 7.7 levels, and follow-up duration: 43.3 mo). Postoperative SAAS categories were as follow: undercorrection (13.4%), matched correction (30.2%), and overcorrection (56.4%). The PJK/F rates were significantly higher in the overcorrection group relative to PI-LL component (P=0.001) as well as SAAS (P=0.038) compared to undercorrection or matched correction groups. The clinical outcomes were best in patients who achieved matched correction relative to PI-LL component as well as SAAS compared to the other correction groups. However, the differentiating power of clinical outcomes across the correction categories was greater in the PI-LL component than in the SAAS.

Conclusion.
This study validated the efficacy of SAAS system to differentiate PJK/F development and good clinical outcomes. However, its differentiating power seems to be largely attributable to the function of the PI-LL component, as the PI-LL correction status better predicted PJK/F risk and clinical outcomes than SAAS.