bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuropathic Pain Experiences of Spinal Cord Injury Patients
Authors: LI Chin-Ching , LIN Hung-Ru , TSAI Ming-Dar , TSAY Shiow-Luan 
Published: November 2017

ABSTRACT

Background:
Neuropathic pain (NP) is a common, severe problem that affects spinal cord injury (SCI) patients. Only SCI patients truly understand the impact and extent of this type of pain.

Purpose:
The aim of this study was to understand the NP experienced by SCI patients and the influence of this type of pain on their daily life.

Method:
A qualitative design was used. An interview guide including a semistructured questionnaire and in-depth interviews was conducted with SCI patients with NP in a neurorehabilitation department at a medical center in northern Taiwan. The data were collected using a purposive sampling method. Content analysis was performed on the interview data, which were obtained from 13 SCI patients with NP.

Results:
Three themes and eight subthemes were identified that described the NP experience of the participants and the influence of NP on their daily life. The three themes included elusive pain (changing and individual pain sensations, erratically haunting threat, and phantom limb sensations), complicated feelings about pain (converting depression into an active attitude toward life, having feelings of anticipation and anxiety about future pain relief, and facing and experiencing pain), and renewed hope (bravely fighting pain and seeking pain relief methods).

Conclusions:
This study revealed three important themes of NP experienced by SCI patients, including elusive pain, complicated feelings about pain, and renewed hope. Nurses should understand the nature of NP, provide a thorough pain assessment, and design a proper pain management plan to care effectively for patients with NP.
Avoiding Small Intestinal Biopsies for Diagnosis of Celiac Disease in Children
Authors: Araya Magdalena , Díaz Julia , Oyarzun Amaya , Lucero Yalda , Alarcon Teresa , González Mónica , Canales Paulina , Fierro Liliana , Pérez‐Bravo Francisco 
Published: November 2017

ABSTRACTBackground:Current reports applying ESPGHAN exception criteria (EEC) to diagnose celiac disease (CD) without duodenal biopsies indicate that a high percentage of patients with CD may be identified when applied correctly in specialized settings. Application of the EEC, however, in “daily life conditions” at the different levels of medical services is not clear.Methods:EEC was applied to 130 pediatric patients evaluated for CD at 5 public hospitals in Santiago, Chile, during 2010 to 2015. Clinical presentation, serum anti‐tissue transglutaminase 2 and anti‐endomysium antibodies (EMA), genotyping, and small intestinal histology were obtained from clinical charts.Results:A total of 78 of 130 patients reviewed had some of the data required for analysis, but EMA was determined in 54% and genotyping in 2.3% of patients, limiting the study. After offering free genotyping, only 12 of 78 (15%) had all data required for EEC application. In this small group, 10 of 12 (83.3%) patients could avoid duodenal biopsies and 2 (16.7%) with potential CD were misdiagnosed. Main reasons for not doing EMA and genotyping were that they are expensive, unavailable in the local health care center, and considered “not necessary” for diagnosis.Conclusion:Limited resources in clinical settings reduce availability of EMA and genotyping, making application of EEC criteria difficult and only possible only in 15% of our patients. Within this subgroup, biopsies could be avoided in 83.3%, and 16.7% of patients with potential CD were misdiagnosed. Insufficient studies and incorrect interpretation of EEC contributed to incomplete assessment in 52 of 130 (40%) patients. The Chilean public health system is likely representative of several others present in developing and developed countries.
Refractive Error in a Sample of Black High School Children in South Africa
Authors: Wajuihian Samuel Otabor , Hansraj Rekha 
Published: November 2017

SIGNIFICANCE
This study focused on a cohort that has not been studied and who currently have limited access to eye care services. The findings, while improving the understanding of the distribution of refractive errors, also enabled identification of children requiring intervention and provided a guide for future resource allocation.

PURPOSE
The aim of conducting the study was to determine the prevalence and distribution of refractive error and its association with gender, age, and school grade level.

METHODS
Using a multistage random cluster sampling, 1586 children, 632 males (40%) and 954 females (60%), were selected. Their ages ranged between 13 and 18 years with a mean of 15.81 ± 1.56 years. The visual functions evaluated included visual acuity using the logarithm of minimum angle of resolution chart and refractive error measured using the autorefractor and then refined subjectively. Axis astigmatism was presented in the vector method where positive values of J0 indicated with-the-rule astigmatism, negative values indicated against-the-rule astigmatism, whereas J45 represented oblique astigmatism.

RESULTS
Overall, patients were myopic with a mean spherical power for right eye of −0.02 ± 0.47; mean astigmatic cylinder power was −0.09 ± 0.27 with mainly with-the-rule astigmatism (J0 = 0.01 ± 0.11). The prevalence estimates were as follows: myopia (at least −0.50) 7% (95% confidence interval [CI], 6 to 9%), hyperopia (at least 0.5) 5% (95% CI, 4 to 6%), astigmatism (at least −0.75 cylinder) 3% (95% CI, 2 to 4%), and anisometropia 3% (95% CI, 2 to 4%). There was no significant association between refractive error and any of the categories (gender, age, and grade levels).

CONCLUSIONS
The prevalence of refractive error in the sample of high school children was relatively low. Myopia was the most prevalent, and findings on its association with age suggest that the prevalence of myopia may be stabilizing at late teenage years.
Case Report: Masquerading Large-vessel Giant Cell Arteritis
Authors: Jacquier Paul , Wuarin Raphael , Chizzolini Carlo , Thumann Gabriele , Steffen Heimo , Chronopoulos Argyrios 
Published: November 2017

SIGNIFICANCELarge-vessel giant cell arteritis (GCA) can be a diagnostic dilemma for the eye care provider because it may not involve the typical cranial arteries. When any of its potential ocular complications are diagnosed, it is important to consider this unusual form of GCA.PURPOSETo report an unusual ophthalmic presentation of large-vessel GCA with sequential bilateral anterior ischemic optic neuropathy and branch retinal artery occlusion.METHODSA 65-year-old previously healthy woman experienced sequential bilateral anterior ischemic optic neuropathy with branch retinal artery occlusion in the absence of other signs and symptoms suggestive of cranial GCA.RESULTSExtensive workup, including temporal artery biopsy, failed to demonstrate vascular inflammation suggestive of GCA or vascular abnormalities, such as atheromatous plaques, but coincidentally revealed a breast tumor, which was excised. Positron emission tomography scan was performed revealing distinct hypermetabolism of the thoracic and abdominal aorta consistent with large-vessel GCA, and corticosteroid therapy was initiated.CONCLUSIONSLarge-vessel GCA is an underdiagnosed and undertreated type of GCA that does not typically affect the cranial arteries but rather larger proximal aortic branches. When associated with ocular complications, it can be a puzzling diagnostic dilemma for the eye care provider.
Corneal Biomechanical Properties in High Myopia Measured by Dynamic Scheimpflug Imaging Technology
Authors: He Miao , Wang Wei , Ding Hui , Zhong Xingwu 
Published: November 2017

SIGNIFICANCEThe cornea is a viscoelastic tissue with viscous and elastic properties. The information of corneal biomechanical changes in high myopia has implications for understanding the pathogenesis of high myopia and primary open angle glaucoma. However, the knowledge of corneal biomechanics in high myopia is limited.PURPOSETo compare the corneal biomechanical properties in high-myopia subjects and emmetropia subjects.METHODSDynamic Scheimpflug imaging technology was used to measure intraocular pressure, central corneal thickness, and corneal biomechanical parameters, including time at the first applanation, velocity at the first applanation, length at the first applanation, deformation amplitude at the first applanation, time at the second applanation, A2V (velocity at the second applanation), length at the second applanation (A2L), deformation amplitude at the second applanation, time at the highest concavity, radius curvature at the highest concavity (HCR), maximal deformation amplitude (MDA), and peak distance.RESULTSThis study included 40 subjects with high myopia and 61 emmetropia subjects. The high-myopia demonstrated greater MDA compared with the emmetropia (1.07 ± 0.01 vs. 1.02 ± 0.01 mm;P< .001) after adjusting for age and intraocular pressure. Pooling analysis found that the high myopia exhibited a smaller HCR, greater MDA, faster A2V and shorter A2L, with a pooled mean difference of −0.21 mm (95% confidential interval [95% CI], −0.30 to −0.13;P< .001) for HCR, 0.05 mm (95% CI, 0.04 to 0.06;P< .001) for MDA, −0.03 m/s (95% CI, −0.06 to −0.002;P= .034) for A2V, and −0.05 mm (95% CI, −0.08 to −0.02;P= .001) for A2L.CONCLUSIONSEyes with high myopia showed a significantly smaller HCR, greater MDA, faster A2V, and shorter A2L than did those with emmetropia, which indicated that the cornea in an eye with high myopia becomes weaker and more deformable.
Contralateral Involvement of Congenital Muscular Torticollis and Clavicular Fracture
Authors: Yim Shin-Young , Chang Kihong , Ahn Ah-Reum , Park Eun Ji , Kim Jongwoo 
Published: November 2017

Abstract
Congenital muscular torticollis (CMT) is known to concur with some conditions such as developmental dysplasia of the hip or brachial plexus injury, which gives us some insights for pathogenesis of CMT. Although clavicular fracture is the most common fracture in newborns, little is known about concurrence of CMT and clavicular fracture. Our clinical experience led us to realize that concurrence of CMT and clavicular fracture tended to occur on the contralateral side for each other rather than the ipsilateral side. This study aimed to verify contralateral concurrence of CMT and clavicular fracture. This is a retrospective cohort study in a tertiary hospital, including 996 subjects with CMT. Concurrent clavicular fracture was found in 20 of 996 subjects with CMT, with the concurrence rate being 2.01%. Concurrent clavicular fracture and clavicular fracture occurred on the contralateral side for each other in 18 subjects (90%) rather than the ipsilateral side. This contralateral concurrence between side of CMT and clavicular fracture was significant (P = 0.001), with an odds ratio of 81 (P = 0.0032). Concurrent clavicular fracture and clavicular fracture seem to occur significantly more on the contralateral side for each other. Underlying mechanism for consistent contralateral concurrence needs to be verified in the near future.
Oral-Health-Related Quality of Life After Surgical Treatment of Osteonecrosis of the Jaws
Authors: Oteri Giacomo , De Ponte Francesco Saverio , Runci Michele , Peditto Matteo , Marcianò Antonia , Cicciù Marco 
Published: November 2017

Abstract
The aim of this study is to analyze the clinical outcome and the change in oral-health-related quality of life (QoL) of osteoporotic patients affected by medication-related osteonecrosis of the jaws (MRONJ). Forty-one patients, consecutively treated for a 10-year period, were retrospectively analyzed. All the patients underwent a marginal osseous resective jaw surgery. A clinical 12 months postoperative evaluation has been performed and the complete mucosal healing, the absence of swelling and suppuration, and no signs of disease recurrence were defined like success parameters. Quality-of-life surveys tests like EORTC QQ-C30 and QLQ-HN35 appendices in conjunction with a perceived oral health visual analog scale (VAS) were administered before (time of diagnosis of MRONJ) and after surgery (at least 6 months) in order to record the different oral health status of the treated patients. The majority of MRONJ-diagnosed patients complained symptoms like pain, eating discomfort, and sense problems, with occasional involvement of the social dimension. There was a prevalence of troubles with social eating and social contact.
The complete mucosal healing was achieved in 100% of the patients and the administered survey tests reported a significant improvement in all the investigated spheres. Similarly, an increased mean score of perceived oral health VAS was reported.
Marginal-resective surgery of the necrotic jaw bone can be an effective treatment of osteoporotic patients affected by localized MRONJ. Quality-of-life parameters are demonstrated to be useful for recording the patient-centered outcome of MRONJ treatment.
A Novel Secretome Biotherapeutic Influences Regeneration in Critical Size Bone Defects
Authors: Burdette Alexander J. , Guda Teja , Thompson Michelle E. , Banas Richard , Sheppard Forest 
Published: November 2017

Abstract
Severe traumatic injuries often result in critical size bone defects, which are unable to heal without treatment. Autologous grafting is the standard of care but requires additional surgeries for graft procurement. Amnion-derived multipotent progenitor cells release a secretome of biomolecules identified as integral to the process of bone regeneration and angiogenesis. This secretome is currently under development as a biotherapeutic. The efficacy of this secretome biotherapeutic was evaluated in vitro on the proliferation and migration of mesenchymal stem cells and osteoprogenitor cells as well as in vivo using a critical size rat calvarial defect model. The secretome biotherapeutic was loaded onto a collagen scaffold and placed into the defect, which was allowed to heal for 4 and 12 weeks. The secretome biotherapeutic enhanced the proliferation and migration of mesenchymal stem cells and proliferation of osteoprogenitor cells. Further, the secretome biotherapeutic improved new bone volume and connectivity by 12 weeks and significantly improved angiogenesis at 4 weeks and bone density at 4 and 12 weeks with no deleterious effects. The improvement in new bone volume, connectivity, and angiogenesis suggests that the secretome biotherapeutic has beneficial effects for bone healing and a higher dose of the secretome biotherapeutic may further improve regeneration.
Treatment of Maxillary Hypoplasia in Cleft Lip and Palate: Segmental Distraction Osteogenesis With Hyrax Device
Authors: Fariña Rodrigo , Diaz Alejandro , Pantoja Roberto , Bidart Carolina 
Published: November 2017

AbstractThe objective of this work is to describe a segmental maxillary distraction osteogenesis (SDO) with segmental Lefort I with an inexpensive device.Four patients who presented severe class III and maxillary hypoplasia due to cleft lip and palate sequel were treated. A SDO was performed using a dental-anchored Hyrax device, achieving enlargement of the upper jaw without altering speech, with adequate and stable occlusion. Dental implants in a new formed bone were installed.The authors can conclude that SDO is a good treatment alternative for patients with maxillary hypoplasia. It preserves velopharyngeal function and is a stable treatment, maintaining the overjet achieved with distraction osteogenesis, without changes in posterior occlusion. The open bite generated with tooth-borne devices can be solved with temporary anchorage devices and intermaxillary elastics during consolidation phase. Modified Hyrax device allows expanding and moving forward the maxillary arch, with a low cost.
Effect of Long-Term Use of Facemask With Miniplate on Maxillary Protraction in Patients With Cleft Lip and Palate
Authors: On Sung Woon , Baek Seung-Hak , Choi Jin-Young 
Published: November 2017

Abstract
The purpose of this retrospective study was to investigate the effect of a long-term use of facemask with miniplate (FM-MP) on maxillary protraction in cleft lip and palate (CLP) patients. The subjects were 21 CLP patients (16 unilateral CLP and 5 bilateral CLP patients), who were treated with identical lip and palate surgical method and FM-MP therapy performed by single surgeon and single orthodontist. Lateral cephalogram was taken before (T1; mean age, 11.1 years) and after maxillary protraction (T2; mean age, 16.9 years). The mean duration of FM-MP was 68.0 months. After 17 cephalometric variables were measured, statistical analysis was performed. During T1-T2, the maxilla showed significant forward movement (ΔA-vertical reference plane, 4.8 mm, P < 0.001; ΔSNA, 1.9 degree, P < 0.001; ΔA-N perp, 1.9 mm, P < 0.05), although the mandible exhibited a forward growth (ΔSNB, 1.2 degree, P < 0.05). Despite downward movement of the posterior maxilla with counterclockwise rotation (Δpalatal plane angle, −1.5 degree, P < 0.05), the mandible did not exhibit clockwise rotation but counterclockwise rotation (ΔSN to mandibular plane angle, −1.4 degree, ΔBjork sum, −1.4 degree, Δocclusal plane to SN plane angle, −1.5 degree, ΔFMA, −1.0 degree, all P < 0.05) and showed decrease in Gonial angle (−1.2 degree, P < 0.01). Although there was labioversion of the maxillary incisor (ΔU1 to SN, 4.1 degree, P < 0.05), the mandibular incisor did not exhibit significant linguoversion (ΔIMPA, −1.3 degree, P
> 0.05). Long-term use of FM-MP is effective on maxillary protraction in adolescent CLP patients without clockwise rotation of the mandible, the main drawback of conventional facemask with tooth-borne anchorage.
Neuro-Ophthalmology at a Tertiary Eye Care Centre in India
Authors: Dhiman Rebika , Singh Digvijay , Gantayala Shiva P. , Ganesan Vaitheeswaran L. , Sharma Pradeep , Saxena Rohit 
Published: November 2017

Background:
Neuro-ophthalmology as a specialty is underdeveloped in India. The aim of our study was to determine the spectrum and profile of patients presenting to a tertiary eye care center with neuro-ophthalmic disorders.

Methods:
A retrospective hospital-based study was conducted, and records of all patients seen at the neuro-ophthalmology clinic of Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, over a 1-year period were retrieved and evaluated.

Results:
Of a total of 30,111 patients referred to various specialty clinics in a span of 1 year, 1597 (5%) were referred for neuro-ophthalmology evaluation. The mean patient age was 30.8 ± 19.5 years, with a male dominance (M:F = 2.02:1). Among these patients, optic nerve disorders were noted in 63.8% (n = 1,020), cranial nerve palsy in 7% (n = 114), cortical visual impairment in 6.5% (n = 105), and others (eye/optic nerve hypophasia, blepharospasm, and optic disc drusen) in 6% (n = 95). Among the patients with optic nerve disorders, optic neuropathy without disc edema/(traumatic optic neuropathy, hereditary, tumor-related, retrobulbar neuritis, toxic, and idiopathic) was noted in 42.8% (n = 685) and optic neuropathy with disc edema (ischemic optic neuropathy, papilledema, post-papilledema optic atrophy, papillitis, neuroretinitis, and inflammatory optic neuropathy) in 20.9% (n = 335). Sixteen percent of patients (n = 263) were incorrect referrals.

Conclusion:
The neuro-ophthalmic clinic constitutes a significant referral unit in a tertiary eye care center in India. Traumatic and ischemic optic neuropathies are the most common diagnoses. Neuro-ophthalmology requires further development as a subspecialty in India to better serve the nation's population.
Quantitative chemical biosensing by bacterial chemotaxis in microfluidic chips
Authors: Roggo Clémence , Picioreanu Cristian , Richard Xavier , Mazza Christian , van Lintel Harald , van der Meer Jan Roelof 
Published: November 2017

SummaryWhole‐cell bacterial bioreporters are proposed as alternatives to chemical analysis of, for example, pollutants in environmental compartments. Commonly based on reporter gene induction, bioreporters produce a detectable signal within 30 min to a few hours after exposure to the chemical target, which is impractical for applications aiming at a fast response. In an attempt to attain faster readout but maintain flexibility of chemical targeting, we explored the concept for quantitative chemical sensing by bacterial chemotaxis. Chemotaxis was quantified from enrichment of cells across a 600 µm‐wide chemical gradient stabilized by parallel flow in a microfluidic chip, further supported by transport and chemotaxis steady state and kinetic modelling. As proof‐of‐concept, we quantified Escherichia coli chemotaxis towards serine, aspartate and methylaspartate as a function of attractant concentration and exposure time. E. coli chemotaxis enrichment increased sharply between 0 and 10 µM serine, before saturating at 100 µM. The chemotaxis accumulation rate was maximal at 10 µM serine, leading to observable cell enrichment within 5 min. The potential application for biosensing of environmental toxicants was investigated by quantifying chemotaxis of Cupriavidus pinatubonensis JMP134 towards the herbicide 2,4‐dichlorophenoxyacetate. Our results show that bacterial chemotaxis can be quantified on a scale of minutes and may be used for developing faster bioreporter assays.
Metaproteomics reveals major microbial players and their metabolic activities during the blooming period of a marine dinoflagellateProrocentrum donghaiense
Authors: Li Dong‐Xu , Zhang Hao , Chen Xiao‐Huang , Xie Zhang‐Xian , Zhang Yong , Zhang Shu‐Feng , Lin Lin , Chen Feng , Wang Da‐Zhi 
Published: November 2017

SummaryInteractions between bacteria and phytoplankton during bloom events are essential for both partners, which impacts their physiology, alters ambient chemistry and shapes ecosystem diversity. Here, we investigated the community structure and metabolic activities of free‐living bacterioplankton in different blooming phases of a dinoflagellateProrocentrum donghaienseusing a metaproteomic approach. TheFibrobacteres‐Chlorobi‐Bacteroidetesgroup,Rhodobacteraceae, SAR11 and SAR86 clades contributed largely to the bacterial community in the middle‐blooming phase while thePseudoalteromonadaceaeexclusively dominated in the late‐blooming phase. Transporters and membrane proteins, especially TonB‐dependent receptors were highly abundant in both blooming phases. Proteins involved in carbon metabolism, energy metabolism and stress response were frequently detected in the middle‐blooming phase while proteins participating in proteolysis and central carbon metabolism were abundant in the late‐blooming phase. Beta‐glucosidase with putative algicidal capability was identified from thePseudoalteromonadaceaeonly in the late‐blooming phase, suggesting an active role of this group in lysingP.donghaiensecells. Our results indicated that diverse substrate utilization strategies and different capabilities for environmental adaptation among bacteria shaped their distinct niches in different bloom phases, and certain bacterial species from thePseudoalteromonadaceaemight be crucial for the termination of a dinoflagellate bloom.