bluuebunny/crossref_metadata_2025_split huggingface dataset:
A dynamic histone-based chromatin regulatory toolkit underpins genome and developmental evolution in an invertebrate clade
Authors: Martín-Zamora Francisco M. , Cole Joby , Donnellan Rory D. , Guynes Kero , Carrillo-Baltodano Allan M. , Dickman Mark J. , Hurd Paul J. , Martin-Duran Jose M 
Published: October 2024

Abstract

Eukaryotic histones protect and package nuclear DNA into nucleosomes. The dynamic addition and removal of posttranslational modifications on these proteins define regulatory regions that play a central role in genome and chromatin biology. However, our understanding of these regulatory mechanisms in animals is primarily based on a few model systems, preventing a general understanding of how histone-based regulation unfolds and promotes phenotypic variation during animal embryogenesis. Here, we apply a comprehensive multi-omics approach to dissect the histone-based regulatory complement in Annelida, one of the largest invertebrate phyla. Annelids exhibit a conserved histone repertoire organised in clusters of dynamically regulated, hyperaccessible chromatin. However, unlike other animals with reduced genomes, the worm Dimorphilus gyrociliatus shows a dramatically streamlined histone repertoire, revealing that genome compaction has lineage-specific effects on histone-based regulation. Notably, the annelid Owenia fusiformis has two H2A.X variants that co-occur in other animals, sometimes associate with fast cell divisions, and represent a unique case of widespread parallel evolution of a histone variant in Eukarya. Histone-modifying enzyme complements are largely conserved amongst annelids. Yet, temporal differences in the expression of a reduced set of histone modifiers correlate with distinct ontogenetic traits and variation in the adult landscapes of histone modifications, as revealed by quantitative mass spectrometry in O. fusiformis and Capitella teleta. Collectively, our unparalleled analysis of histone-based epigenetics within a non-model phylum informs the evolution of histone-based regulation, presenting a framework to explore how this fundamental genome regulatory layer contributes to developmental and morphological diversification in annelids and animals generally.
NT-pro BNP as a Prognostic Indicator for Chronic Heart Failure in Geriatric Population - A Pilot Study
Authors: Arachchi Eranda Ranasinghe , Agboyibor kouamivi , Gunavardhan  
Published: October 2024

Abstract

Background
As per the updated NICE guidelines, brain (B-type) natriuretic peptide (BNP) is used in the diagnostic criteria and management of heart failure. In this study, we aimed to evaluate the prognostic value of the inactive N-terminal fragment NT-proBNP in an elderly population with decompensated heart failure.
Materials & Methods
We conducted a retrospective observational cohort study of 88 elderly patients who were admitted with decompensated heart failure between September 2023 to April 2024, covering the South Eastern Trust in Northern Ireland. Suspected heart failure admissions were randomly selected to obtain snapshots of each month. Among these admissions, 88 heart failure cases were identified based on echocardiogram findings and NT-proBNP levels obtained at initial admission. The same cohort was followed up for 12 weeks to monitor two specific end points: re-admission with heart failure or death.
Heart failure follow-ups were also assessed post-discharge. All cases were categorized into two main cohorts: a heart failure with reduced ejection fraction (HFrEF/EF > 60%) cohort and a heart failure with preserved ejection fraction (HFpEF/EF > 40%) cohort. Prognostic values and all-cause mortality after discharge were assessed for each cohorts via multivariable adjusted Cox regression analysis. Each cohort was further divided into three sub-cohorts based on NT-proBNP value
Results
The data analysis showed that patients with NT-proBNP values of >2000 exhibited a mortality rate of 29.1% and a heart failure re-admission rate of 45.6%. Those with rising NT-proBNP values during heart failure follow-up exhibited a re-admission rate of 66.6%, which was much lower than that (33.3%) seen in those with declining NT-proBNP values.
Conclusions
Our results indicated that higher NT-proBNP levels on admission were predictive of higher mortality and re-admission rates among the elderly population. Furthermore, rising NT-proBNP levels during heart failure follow up were associated with higher mortality and morbidity rates. Therefore, NT-proBNP levels can be used as a prognostic biomarker for elderly patients with heart failure, irrespective of their ejection fraction status.
Transmissibility-based methods for damage identification on a railway bogie frame
Authors: Pagaimo João , Millan Pedro , Costa João Neves , Maia Nuno , Ambrósio Jorge 
Published: October 2024

Abstract

The bogie frame is a safety-critical component of modern railway vehicles. Consequently, railway companies periodically inspect the bogie frame to guarantee a timely damage detection. Current inspection strategies could benefit from condition monitoring during the operation using adequate sensor systems and algorithms. However, the application of methods for damage detection using the bogie frame response is still limited. This work aims to identify the sensitivity of two complementary methods based on the transmissibilities – an updated form of the Transmissibility Damage Indicator (TDI) method and the Maximum Occurrences (MO) method – to detect and locate structural damage. This analysis is supported by flexible multibody simulations that provide the nominal and abnormal response of a locomotive in realistic operational conditions. This work first assesses the effect of differences in track inputs on the sensitivity of the TDI method. Both the length of acceleration signals and the number and location of sensors are analysed, from the perspective of the damage detection capacity. The results show that the TDI method successfully detects cracks with a moderate to large dimension, while the MO method identifies the region where those cracks occur. The transmissibility-based methods are a reliable technique that may contribute to enhance the inspection of railway vehicles.
Probing intracellular yeast metabolism with deuterium magnetic resonance spectroscopy
Authors: Anum Fatima , Assaf Charbel , Mohamad Farhad Haj , Anikeeva Maria , Brahms Arne , Dey Jyotirmoy , Kaltenberger Simon , Beitz Eric , Welz Lina , Annis Victoria , Gemmeren Manuel van , Duckett Simon , Hövener Jan-Bernd , Pravdivtsev Andrey N. 
Published: October 2024

Abstract

Metabolomics provides insights into biochemical dynamics, with nuclear magnetic resonance (NMR) being one of the few noninvasive techniques. However, traditional 1H NMR often suffers from overlapping signals from proteins and numerous metabolites. To address this, we employed deuterium labeling, reducing background interference and streamlining metabolic analysis. Deuterium magnetic resonance spectroscopy (DMRS) enables rapid, noninvasive measurement of metabolic flux without specialized equipment. In our study, we first measured T1, T2, and chemical shifts for 25 deuterium-labeled compounds in phosphate-buffered saline: parameters functional for optimal DMRS settings. Among the 25 deuterated compounds tested with food-grade baker’s yeast (Saccharomyces cerevisiae) as a model solution, we observed and tracked the real-time consumption of pyruvate, glucose, fumarate, acetone, and nicotinamide. We redirected yeast metabolism by (i) varying concentrations of added pyruvate and (ii) osmotic pressure by changing buffer density. This study underscores DMRS’s potential as a robust, versatile tool for dissecting metabolic transformations exemplified here with the convenient yeast cell systems active for hundreds of minutes under typical NMR observation conditions.
HISTÓRIA E CULTURA AFROCENTRADA: REFLEXÕES IDENTITÁRIAS DOS ESTUDANTES DO ENSINO MÉDIO
Authors: Da Silva Santos Jonas , Nascimento dos Santos Carla Liane 
Published: October 2024

Este artigo é fruto do desdobramento de uma ação desenvolvida na sala de aula no Curso de Pós-Graduação Lato Sensu em Relações Étnico-Raciais e Cultura Afro-Brasileira na Educação, realizada junto a uma turma de história e cultura afro-brasileira e africana no processo de construção e afirmação identitária dos estudantes do Ensino Médio. O presente trabalho foi desenvolvido no turno vespertino, no período de 21 de setembro de 2022 a 29 de setembro de 2022, utilizando o método da pesquisa-ação, a partir do planejamento e vivência de uma sequência didática. A pesquisa revelou-se como uma estratégia pedagógica viável para potencializar os estudos sobre a História e Cultura Afro-Brasileira e Africana, capaz de transformar os sujeitos e suas realidades. Os referenciais teóricos utilizados estiveram amparados nas produções de Appiah (1992); Fanon (2008); Gomes (2017); Munanga (2005); Santos (2005); Silva (2007). Assim, este estudo contribuiu para o reconhecimento e afirmação identitária dos (as) estudantes, apontando possibilidades de ações concretas em direção à superação de uma educação monocultural e eurocêntrica.
MOVIVÊNCIAS
Authors: Campos de Paula Débora , Martielo Renata Giovana de Almeida 
Published: October 2024

O tema que trataremos neste artigo, para nós é um oásis no meio do caos, uma experiência de encontro com nossas intimidades de ser. Falar de movimento corporal afro referenciado e das experiências que vêm sendo desenvolvidas nas provocações do que chamamos de movivências, enquanto expressão e produção de saberes/filosofias do corpo, é tocar em discussões muito caras a nossa trajetória pessoal e acadêmica.
A experiência com o trabalho desenvolvido no Núcleo de Pesquisas em Filosofias do Corpo[1] nos proporciona entrar em contato com questões prementes do nosso entendimento sobre quem somos, o que estamos fazendo no mundo enquanto seres humanos e o que queremos para nossa existência coletiva. Nossos contatos se dão a partir do corpo em movimento, mas não qualquer movimento, são sim as expressões da capoeira e as possibilidades da dança afro-brasileira, vivenciadas sobre uma perspectiva libertadora, reflexiva e contra a colonialidade que aprisiona nossos corpos pensantes. Chamamos essa experiência sensório motora de Movivências.
LOUVAÇÃO AO BAOBÁ NA/DA CIDADE DE MOSSORÓ/RN
Authors: Marques Leite Lucas Sullivam , Aguiar Ana Lúcia Oliveira 
Published: October 2024

O artigo em tela tem como objetivo, apresentar uma síntese de uma recente pesquisa em nível de mestrado em Educação, intitulada, “Louvação ao Baobá na Cidade de Mossoró/RN: Memórias, Identidades Negras e Saberes Ancestrais”, desenvolvida na linha de pesquisa Práticas Educativas, Cultura, Diversidade e Inclusão do Programa de Pós-Graduação em Educação da Universidade do Estado do Rio Grande do Norte, com financiamento da CAPES. Resulta de uma pesquisa de abordagem qualitativa, bibliográfica e explicativa (quanto aos objetivos) fundamentada na interface entre a Metodologia da Pesquisa (Auto) Biográfica e Filosofias Afro-Brasileiras. Os resultados apontam que perspectivas epistêmico-metodológicas em construção, podem compreender e veicular histórias de vida, memórias, experiências e saberes ancestrais, com impactos diretos na cultura e educação afro-brasileira.
Medication Adherence, Blood Pressure Control, Knowledge, Self-care and Self-efficacy among Tunisian Hypertensive Patients
Authors: Turki Fatma , Turki Imen , Jedidi Jihen , Said Houyem 
Published: October 2024

Objectives
The aim of this study was to investigate the associated factors with adherence to antihypertensive therapy and to explore the association between medication adherence, blood pressure control, knowledge about hypertension (HTN), self-care, and self-efficacy in hypertensive patients.

Methods
A cross-sectional study was conducted among 750 hypertensive patients in Tunisia. The data collection tool was a 5-section questionnaire including an information sheet, the Girerd medication adherence scale, the HTN Knowledge Level Scale (HK-LS), the Self-care of HTN Inventory (SC-HI), and the Self-Efficacy for Managing Chronic Disease 6-Item Scale (SEM6S).

Results
A low and moderate level of medication adherence has been observed in 83.2% of the participants. Uncontrolled blood pressure was detected in 73.1% of cases. Only 11.5% have a good level of knowledge about HTN. Concerning Self-care practices, 48.8% of patients have inadequate practices of maintenance, 48.8% have inadequate practices of monitoring, and 83.9% have inadequate practices of management. The self-efficacy for managing HTN was weak in 42.1% of the participants.
In multivariate analysis, low medication adherence was associated with the number of antihypertensive pills/day (ORa=2.668; CI95%= (1.447- 4.918) if ≥ 4 pills/day), side effects (ORa=1.834; CI95%= (1.263- 2.665); p=0.001), uncontrolled hypertension (ORa=2.74; CI95%= (1.798- 4.18); p<0.0001), insufficient self-efficacy for managing HTN (ORa=1.773; CI95%=(1.252- 2.512); p<0.0001), and insufficient self-care maintenance (ORa=2.220; CI95%=(1.562- 3.1570); p<0.0001).

Conclusion
Low medication adherence was associated with uncontrolled blood pressure, more anti-hypertensive pills, side effects, lower self-efficacy, and lower self-care maintenance. Nursing interventions improving the management skills of hypertensive patients may be beneficial in controlling the disease and its subsequent consequences.
A Comprehensive Review on the Screening Models for the Pharmacological Assessment of Antipsychotic Drugs
Authors: Singh Yatendra , Rai Nitish , Wal Pranay 
Published: October 2024

Background:
Psychosis is a debilitating mental disorder characterized by a
profound disconnection from reality, manifesting in symptoms such as hallucinations,
delusions, and disorganized thinking. The pathophysiology of psychosis is multifaceted,
involving an interplay of neurobiological, genetic, and environmental factors.
Neurobiologically, dysregulation of neurotransmitter systems particularly dopaminergic,
serotonergic, and glutamatergic pathways-plays a central role, with excessive dopaminergic
activity linked to positive symptoms and glutamatergic dysfunction implicated
in cognitive impairments. Genetic predisposition, evidenced by significant
heritability and associations with specific genetic variants, intersects with environmental
factors such as stress, trauma, and substance use to influence the onset and
progression of psychosis. Cognitive disruptions, including deficits in attention,
memory, and executive function, exacerbate the disorder’s impact. This phenomenon
has led to short-term as well as long-term psychosocial and mental health implications
for all.

Objective:
To determine the antipsychotic activity of pharmaceuticals, numerous antipsychotic
screening models are available. Determining the optimal animal model for
measuring antipsychotic activity is the primary goal of this study.

Methods:
A search for literature was carried out using several keywords, including
"Antipsychotic," "In-vivo models," "In-vitro models," and "Behavior models," on the
databases Science Direct and PubMed. For the purpose of obtaining the most appropriate
articles to fulfil the goal of this review article, the search was customized by
using the necessary filters.

Results:
Research and review articles based on neuroleptic screening models are
available to determine the antipsychotic activity of novel pharmacological compounds.

Conclusion:
Following our research, we identified several helpful models for evaluating
the antipsychotic activity of pharmaceuticals and proposed that combining invitro
and in-vivo techniques with behavioral methodologies might yield the most appropriate
results for our field of study.
Jivamrit as a Sustainable Approach: A Review of Natural Farming and Future Agriculture
Authors: Warghane Ashish , Bhatt Vaibhav , Chopade B.A , Thakkar Jigisha , Sharma Ritu , Mondal Arijit , Sabhadiya Priyanka , Singh Ankit , Bhardwaj Gayatary 
Published: October 2024

Abstract:
Green Revolution aims to boost food production and feed millions of Indians, but it also has negative effects on agriculture and society's health. Natural manures like cow dung and cow urine can counteract the adverse effects of inorganic fertilizer on soil along with improving physicochemical qualities, maintaining the soil quality, and increasing crop output. Zero Budget Natural Farming (ZBNF) formulations like Jivamrit promote soil health and microbial activities and are an excellent source of macronutrients, other micronutrients needed for plant growth, plus adds beneficial microbes, nitrogen (N2), phosphorus (P), potassium (K), and natural carbon (C). Further, conventional agricultural methods, like monocropping and heavy tillage, can damage soil bacteria which contributes to sustainable agriculture through nitrogen fixation, siderophore synthesis and nutrient absorption. A sustainable agricultural system is resource-efficient, socially and commercially competitive, ecologically sound, and supportive of society. Jivamrit, a natural organic manure, is gaining interest due to concerns about the sustainability of input-intensive agriculture systems. It promotes crop growth, quality, and yield, enhances soil pH, population, and activity of beneficial microorganisms, and helps with nitrogen fixation, phosphate solubili-zation, and easy decomposition. Long-term use of Jivamrit, may disrupt soil microbial balance, may leading to overpopulation of certain species. The current review on the Jivamrit emphasizes on the biological and chemical characterization and its significance to the agriculture.
A Passenger Ship Emergency Evacuation Line Efficiency Evaluation Operator Considering Safety Capacity and its Application
Authors: Ni Huan , Zhang Fangwei , Li Junbo , Pan Yiying 
Published: October 2024

Introduction:
Aiming at evaluating the efficiency of passenger ship emergency
evacuation routes, this study proposes an evaluation operator for passenger ship emergency
evacuation routes, and then conducts simulation research on the passenger ship evacuation
process.

Methods:
The main innovations of this study are as follows. Firstly, this study proposes an
evaluation operator for passenger ship emergency evacuation lines based on consideration of the
passage capacity, ship heeling effect, traffic flow obstruction, personnel evacuation mood,
accident location, and other factors. Secondly, this study discretizes the emergency evacuation
path of passenger ships into a three-dimensional topological network structure and uses simulation
data to calculate the traffic capacity between nodes. By comparing the calculated value with the
simulated value, a risk assessment method for emergency evacuation is given. Thirdly, this study
takes the three-story ro-ro passenger ship in the European "SAFEGUARD" project as an example
and gives three passenger ship evacuation simulation processes under different passenger flow
densities.

Results:
The results of the calculation example show that the risk-prone areas are mainly
concentrated in the passenger ship stairs, and the risk value increases with the passenger flow.

Conclusion:
The calculation results verify the effectiveness of the emergency evacuation line efficiency
evaluation operator proposed in this study.
Pengaruh Luas Pengungkapan Corporate Social Responsibility Dan Profitabilitas Terhadap Nilai Perusahaan
Authors: Tianingrum Putri Andriany Agus , Roekhudin  
Published: October 2024

The rapid development of the business world requires companies to increase their value, which is the basis for investor and public perceptions in assessing and analyzing the company's financial performance. Also, investors now consider the company's economic, social, and environmental responsibilities in making investment decisions. This research examines the effect of Corporate Social Responsibility (CSR) disclosure and profitability on the firm value of food and beverage manufacturing companies listed on the Indonesia Stock Exchange in 2021-2022. This research includes 50 samples based on established criteria, selected through purposive sampling, and analyzed by multiple regression. The CSR disclosure is measured based on the 2016 Global Reporting Initiative Standards indicator items, profitability is represented by Return on Equity (ROE), and firm value is represented by Tobin’s Q. The results of this research exhibit that the CSR disclosure partially has no positive effect on firm value while profitability partially has a positive impact on firm value. Simultaneously, CSR disclosure and profitability have a positive effect on firm value.
Abstrak
Semakin pesatnya perkembangan dunia bisnis mengharuskan perusahaan mampu meningkatkan nilai perusahaan yang dijadikan dasar persepsi investor dan masyarakat dalam menilai serta menganalisis kinerja keuangan perusahaan. Seiring dengan hal itu, Kini investor juga mempertimbangkan tanggungjawab ekonomi, sosial, dan lingkungan perusahaan dalam mengambil keputusan investasi. Penelitian ini bertujuan untuk menguji pengaruh luas pengungkapan Corporate Social Responsibility dan profitabilitas terhadap nilai perusahaan manufaktur sub sektor industri makanan dan minuman yang terdaftar di Bursa Efek Indonesia tahun 2021-2022. Adapun metode yang digunakan dalam penelitian ini yaitu analisis regresi linier berganda dengan metode penentuan sampel purposive sampling dan kemudian diperoleh 50 buah sampel yang memenuhi kriteria. Variabel luas pengungkapan CSR diukur berdasarkan item indikator Global Reporting Initiative Standards 2016, variabel profitabilitas diproksikan dengan Return on Equity (ROE), sedangkan variabel nilai perusahaan diproksikan dengan Tobin’s Q. Hasil penelitian ini menunjukkan bahwa variabel luas pengungkapan CSR secara parsial tidak berpengaruh positif terhadap nilai perusahaan, sedangkan variabel profitabilitas secara parsial berpengaruh positif terhadap nilai perusahaan. Serta variabel luas pengungkapan CSR dan profitabilitas secara simultan berpengaruh positif terhadap nilai perusahaan.