bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the effect of therapy duration on survival in patients with metastatic castration-resistant prostate cancer receiving radium-223.
Authors: Williams Noelle L. , Nowak-Choi Kamila , Skowronski Jenna , Dan Tu , Eldredge Harriet Belding , Hoffman-Censits Jean H. , Lin Jianqing , Kelly William Kevin , Gomella Leonard G. , Lallas Costas D. , Trabulsi Edouard John , Hurwitz Mark , Dicker Adam , Leiby Benjamin E. , Dabbish Nooreen , Den Robert B. 
Published: March 2017

e593 Background: The use of radium-223 in patients with metastatic castration-resistant prostate cancer (mCRPC) improves overall survival (OS) and quality of life. Combination of radium-223 with second-generation anti-androgens has further improved OS; however, the optimal length of radium-223 treatment for maximal effect remains unknown. Methods: We reviewed 35 consecutive patients with mCRPC who received radium-223 from December 2012 to August 2015 at Thomas Jefferson University. Patients were divided into two groups: those who received full treatment of 6 injections (n = 18) versus those who received less than 6 injections (n = 17). Kaplan-Meier analysis of OS were tested for difference by treatment group using Log Rank test. Univariable association with survival outcomes was calculated with univariable Cox regression and Log Rank tests. Results: Mean age was 73 ± 10 years and Karnofsky performance status (KPS) ranged from 50-90 (median, 80). Median follow-up was 13.9 months. Eighteen patients were receiving concurrent second generation anti-androgens at the start of treatment. Median OS was 12 months for patients who received 6 injections and 6.48 months for patients who received less than 6 injections (p = 0.0045). The results of univariate Cox regression analysis revealed full treatment was associated with increased OS (p = 0.0013). On multivariate analysis accounting for KPS, full treatment was significantly associated with improved OS (p = 0.0028). Conclusions: In this retrospective, single-institution analysis, we demonstrated that full course completion of radium-223 was associated with improved OS in patients with mCRPC. These patients should be optimally supported during treatment to allow for therapy completion.
The impact of multifocal perineural invasion on biochemical recurrence and timing of adjuvant androgen-deprivation therapy in high-risk prostate cancer following radical prostatectomy.
Authors: Shen Pengfei , Sun Guangxi , Zeng Hao , Zhang Xingming 
Published: March 2017

e595 Background: Perineural invasion (PNI) is a distinct pathologic entity and a recognized source of tumor spread. However, the role of PNI in high-risk prostate cancer (PCa) has not been explored. We investigated the impact of the severity of PNI on biochemical recurrence (BCR) and optimal timing of adjuvant androgen deprivation therapy (ADT) post radical prostatectomy (RP). Methods: Of 265 prostatectomies, median follow-up 45 months, were assessed for the presence of PNI and its intensity (unifocal PNI and multifocal PNI) in RP specimen. Kaplan-Merier curves were used to estimate BCR probabilities. Cox proportional hazard models were used to address predictors of BCR. Harrell’s C-index was conducted to further validate prognostic value of multi-PNI. Results: A total of 123 patients (46.4%) were PNI positive, among which, 91 (74%) and 32 (26%) had unifocal PNI (uni-PNI) and multifocal PNI (multi-PNI), respectively. Other than uni-PNI, the presence of multi-PNI was strongly associated with increasing incidence of BCR (HR = 3.87, 95% CI: 1.66-9.01, p = 0.002). Patients with uni-PNI seemed to have a similar BCR rate to those without PNI after adjuvant ADT. For men with multi-PNI, immediate ADT obviously appeared to be superior to delayed ADT in decreasing biochemical failure. Conclusions: Multi-PNI detected in high-risk RP specimens could be a prognosticator for early biochemical relapse post-surgery. Our findings suggest that patients with multi-PNI appear appropriate to choose adjuvant therapy as soon as possible after surgery.
Changes in hormonal therapy during the first 24 months of treatment: A longitudinal cohort study.
Authors: Lebret Thierry , Rossi Dominique , Zerbib Marc , Moreau Jean Luc , Ruffion Alain , Neuzillet Yann , Hennequin Christophe 
Published: March 2017

e599 Background: Data are limited showing changes in patients’ use of androgen deprivation therapy (ADT) in routine clinical practice. Methods: In this non-interventional, longitudinal cohort study, we assessed the number and type of modifications of ADT during the first 24 months of treatment in France. At baseline and every 6 months, we collected clinical, biological and therapeutic data and any changes of ADT modality. Results: Between July 2011 and January 2015, 891 pts were evaluable at 24 months. Mean age was 74.1±8.7 years. Indications for ADT were: biochemical relapse after local treatment (21.4%), adjuvant to radiotherapy (RT) (31.6%), metastases (24.2%) and locally advanced tumor without local treatment (20.6%). Gleason score was > 7, 7(4+3), 7 (3+4) and < 7 in 33.6%, 23.1%, 26% and 17.3%, respectively. At 24 months, modification of ADT was reported in 390 pts (43.8%). Modifications of ADT according to indications are summarized in table below. The main types of modification concerned the formulation (molecule or duration of action) (61.3%), duration of ADT (10.5%), switch to intermittent treatment (10.0%), addition of chemotherapy (5.6%) or second line hormonal manipulation (9.0%). Clear explanation for adaptations was given for only 110 patients: disease progression: 55.5% ; patient request: 26.4%, tolerance: 12.7% and failure of castration: 7.3%. Conclusions: Change of initial modality of ADT is frequent in the first 24 months of treatment (43.8%) and numerically more frequent in presence of metastases or biochemical relapse than when ADT is added to RT. Surprisingly, the main type of modification is formulation. The main reason for modification is disease progression. [Table: see text]
The prognostic role of IDC-P in mCRPC and its predictive value in those treated with docetaxel or abiraterone as first-line therapy.
Authors: Zhao Jinge , Zeng Hao , Shen Pengfei , Sun Guangxi , Liu Jiandong , Zhang Xingming , Chen Zhibin 
Published: March 2017

e603 Background: Intraductal carcinoma of prostate (IDC-P) is recognized as a newly pathological entity in 2016. Its role in metastatic castration-resistant prostate cancer (mCRPC) remains unknown. The aim of this study is to explore the association of IDC-P with clinical outcomes and to further identify its potential predictive role in making first-line treatment decision for mCRPC patients. Methods: We retrospectively analyzed data of 131 men with mCRPC. IDC-P was diagnosed by re-biopsy at the time of mCRPC. After mCRPC, 45 and 41 patients received abiraterone (Abi) or docetaxel (Doc) as first-line therapy, respectively. PSA response, PSA progression-free survival (PSA-PFS) and overall survival (OS) from mCRPC to death were analyzed. Kaplan-Meier curves, log-rank test, Cox regression models and Harrell’s C-index were conducted to analyze disease progression, treatment efficacy and outcomes. Results: The incidence of IDC-P in mCRPC reached to 47.3%. IDC-P was not only related to rapid PSA progression, but also associated with 20-month decrease of OS. Among IDC-P(-) patients, PSA response, PSA-PFS and OS were comparable in Abi-treated and Doc-treated groups. In contrast, among IDC-P(+) patients, PSA response rate is higher in Abi-treated vs. Doc-treated group (52.4% vs. 21.7%; p = 0.035), also, PSA-PFS and OS were much longer in Abi-treated group (PSA-PFS:13.5 vs.6.0 months, p = 0.012; OS:23.6 vs.14.7 months, p = 0.128). Cox regression indicated that, for IDC-P(+) patients, Abi was associated with prolonged time of PSA-PFS (HR = 0.33, 95%CI: 0.14-0.79, p = 0.013), and could significantly increase the predictive accuracy of standard model, with an obvious increase of the C-index from 0.719 to 0.778 (p = 0.009). Conclusions: The presence of IDC-P in mCRPC from re-biopsy was not only an independent prognosticator for clinical outcomes, but also strongly associated with poor response to Doc-based chemotherapy. We also found that IDC-P status could be considered as a novel predictive marker in helping physicians precluding Doc as first-line therapy in IDC-P(+) patients. Also, these findings require large-scale prospective validation.
Single-dose, four-way crossover, open-label, relative bioavailability (BA) studies of a novel formulation of abiraterone acetate (AA) versus the reference formulation under fasted conditions in healthy male subjects.
Authors: Goldwater Ronald , Hussaini Azra , Zhang Yuxin , Bosch Bill , Nemeth Paul 
Published: March 2017

e605 Background: AA is approved for treatment of metastatic castration-resistant prostate cancer. The originator AA (OAA) formulation is poorly absorbed and exhibits large pharmacokinetic variability in abiraterone exposure in healthy subjects. AA fine particle (AAFP) is a proprietary formulation (utilizing SoluMatrix Fine-Particle Technology) that was designed to provide improved BA versus the OAA formulation. Methods: In Study 1, 20 subjects were randomized in a crossover design to single doses of AAFP 100, 200, or 400 mg or OAA 1000 mg. To further expand the AAFP dose range, 36 subjects were randomized in a crossover design to AAFP 125, 500, or 625 mg or OAA 1000 mg in Study 2. Both studies included a 7-day washout period prior to crossover. Results: AAFP 500 mg BA relative to OAA 1000 mg measured by the ratio of test-to-reference geometric means was AUC0-t 93.4% (90% CI: 85.3–102.4%), AUC0-∞ 91.0% (90% CI: 83.3–99.4%), and Cmax99.8% (90% CI: 86.3–115.5%). Dose proportionality was seen across all AAFP dose levels (see table). Between-subject variability for AAFP 500 and 625 mg was similar to OAA 1000 mg. No significant AAFP-related adverse events (AEs), serious AEs, or deaths occurred. Treatment-emergent AEs were mostly Grade 1. Conclusions: AAFP demonstrated improved BA and AAFP 500 mg was bioequivalent to OAA 1000 mg in healthy male volunteers under single dose and fasted conditions. AAFP showed dose proportionality across all doses studied (100–625 mg). Clinical trial information: NCT02737332. [Table: see text]
Avian torpor or alternative thermoregulatory strategies for overwintering?
Authors: Douglas Tegan K. , Cooper Christine E. , Withers Philip C. 
Published: March 2017

ABSTRACTIt is unclear whether torpor really is uncommon amongst passerine birds. We therefore examined body temperature and thermoregulatory strategies of an Austral passerine, the white-browed babbler (Pomatostomus superciliosus), which has characteristics related to a high probability of torpor use; it is a sedentary, insectivorous, cooperative breeding species, which we studied during winter in a temperate habitat. Wild, free-living babblers maintained normothermy overnight, even at sub-zero ambient temperatures, with a mean minimum body temperature of 38.5±0.04°C that was independent of minimum black bulb temperature. Physiological variables measured in the laboratory revealed that babblers had a low basal metabolic rate and evaporative water loss, but their body temperature and thermal conductance were typical of those of other birds and they had a typical endothermic response to low ambient temperature. Huddling yielded significant energy savings at low temperatures and a roost nest created a microclimate that buffered against low temperatures. Low basal energy requirements, communal roosting and the insulation of a roost nest confer sufficient energetic benefits, allowing babblers to meet energy requirements without resorting to heterothermia, even in their depauperate, low-productivity landscape, suggesting that passerine birds use alternatives to torpor to balance their energy budgets when possible.
Liquidity Provision and the Cross Section of Hedge Fund Returns
Authors: Jame Russell 
Published: March 2017

I investigate whether hedge funds that supply liquidity earn superior returns. Using transaction data, I find that hedge funds following short-term contrarian strategies (i.e., liquidity suppliers) earn significantly higher returns on their equity trades and holdings. Similarly, using commercial databases, I find that hedge funds with greater exposure to a liquidity provision factor earn significantly higher excess returns and Sharpe ratios. The superior performance of liquidity-supplying hedge funds arises from strategies that are more complex than mechanical short-term reversal strategies. For example, among stocks with similar past returns, liquidity-supplying funds are more likely to trade against stocks heavily traded by constrained mutual funds and less likely to trade against stocks heavily traded by unconstrained mutual funds. The outperformance of liquidity-supplying funds is also concentrated in periods of low funding liquidity, suggesting that less-binding financial constraints contribute to their superior returns. The Internet appendix is available at https://doi.org/10.1287/mnsc.2016.2687 This paper was accepted by Lauren Cohen, finance.
Opinions of university students regarding pictorial warnings on cigarettes packs<p>Üniversite öğrencilerinin sigara paketleri üzerindeki resimli uyarılar hakkındaki görüşleri
Authors: Özpulat Funda , Bilir Nazmi 
Published: March 2017

This descriptive study was conducted on totally 460 students from the departments of nutrition and dietetic (n=143) and nursing (n=317) of a health college located in Akşehir County of Konya City in the period of December 1st-31st, 2015. Within the scope of the study, age, gender, department and grade characteristics of students, their individual and family member’s status in terms of consuming tobacco products, and their opinions regarding pictorial warnings to be printed on cigarettes packs, regulated by the European Union published on 17.12.2014.As a result of the study, it was determined that students’ opinions regarding efficiency of written and pictorial warnings on cigarettes packs were differing with respect to students’ gender and sigarettes usage status; and that illustrations on cigarettes packs were found more effective by female students and non-cigarettes user.Especially activities such as training programs, seminars/congress/conferences for male students and cigarettes users about tobacco products and their harms could contribute in raising awareness of university youth. Additionally, placing impressive or even scary images in larger sizes emphasizing serious health problems on cigarettespacks could be effective on significant decrease of usage of tobacco products. ÖzetKonya İli Akşehir İlçesinde yer alan bir sağlık yüksekokulunun beslenme diyetetik (n=143) ve hemşirelik bölümünden (n=317) toplam 460 öğrencinin katılımıyla gerçekleştirilen tanımlayıcı tipteki bu çalışma 1-31 Aralık 2015 tarihleri arasında uygulanmıştır. Çalışma kapsamında, öğrencilerin yaşı, cinsiyeti, bölümü, sınıfı, kendisinin ve aile bireylerinin tütün ürünlerini kullanma durumu gibi bazı özellikleri ile sigara paketleri üzerine basılmak üzere Avrupa Birliği tarafından 17.12.2014 tarihinde yayınlanan resimli uyarılar hakkındaki düşünceleri öğrenilmiştir.Yapılan çalışma sonucunda, sigara paketleri üzerindeki yazılı ve görsel uyarıları etkili bulma durumunun öğrencilerin cinsiyetine ve sigara kullanma durumuna göre değiştiği, kız öğrencilerin ve sigara kullanmayanların sigara paketleri üzerindeki ifadeleri daha etkili buldukları saptanmıştır.Özellikle erkek öğrencilere ve sigara kullananlara tütün ürünleri ve zararlarına yönelik düzenlenecek eğitim programları, seminer/kongre/konferans türü etkinlikler üniversite gençliğinin farkındalık düzeyinin arttırılmasına ve bilinçlendirilmelerine katkıda bulunacaktır. Ayrıca, sigara paketleri üzerine daha geniş alanı kapsayan, daha ciddi sağlık sorunlarına işaret eden çarpıcı hatta ürkütücü resimlerin basılması tütün ürünlerinin kullanılmasının önemli ölçüde azaltılmasında etkili olabilir.
Effects of GABAa receptor antagonists on motor behavior in pharmacological Parkinson's disease model in mice
Authors: Mograbi Karla De Michelis , de Castro Ana Carolini Ferreira , de Oliveira Jainny Aniely Rocha , Sales Patrick Jean Barbosa , Covolan Luciene , Del Bel Eliane Aparecida , de Souza Albert Schiaveto 
Published: March 2017

AbstractThe aim of this study was to evaluate the effects of two gamma‐amino butyric acid (GABA)a receptor antagonists on motor behavioral tasks in a pharmacological model of Parkinson disease (PD) in rodents. Ninety‐six Swiss mice received intraperitoneal injection of Haloperidol (1 mg/kg) to block dopaminergic receptors. GABAa receptors antagonists Bicuculline (1 and 5 mg/kg) and Flumazenil (3 and 6 mg/kg) were used for the assessment of the interaction among these neurotransmitters, in this PD model. The motor behavior of the animals was evaluated in the catalepsy test (30, 60, and 90 min after drugs application), through open field test (after 60 min) and trough functional gait assessment (after 60 min). Both Bicuculline and Flumazenil were able to partially reverse catalepsy induced by Haloperidol. In the open field test, Haloperidol reduced the number of horizontal and vertical exploration of the animals, which was not reversed trough application of GABAa antagonists. Furthermore, the functional gait assessment was not sensitive enough to detect motor changes in this animal model of PD. There is an interaction between dopamine and GABA in the basal ganglia and the blocking GABAa receptors may have therapeutic potential in the treatment of PD.
The quest for load‐independent left ventricular chamber properties: exploring the normalized pressure–volume loop
Authors: Kohli Keshav , Kovács Sándor J. 
Published: March 2017

AbstractLeft ventricular (LV) pressure–volume (P–V) loop analysis is the gold standard for chamber function assessment. To advance beyond traditional P–V and pressure phase plane (dP/dt‐P) analysis in the quest for novel load‐independent chamber properties, we introduce the normalized P–V loop. High‐fidelity LV pressure and volume data (161 P‐V loops) from 13 normal control subjects were analyzed. Normalized LV pressure (PN) was defined by 0 ≤ P(t) ≤ 1. Normalized LV volume (VN) was defined as VN=V(t)/Vdiastasis, since the LV volume at diastasis (Vdiastasis) is the in‐vivo equilibrium volume relative to which the LV volume oscillates. Plotting PN versus VN for each cardiac cycle generates normalized P‐V loops. LV volume at the peak LV ejection rate and at the peak LV filling rate (peak −dV/dt and peak +dV/dt, respectively) were determined for conventional and normalized loops. VN at peak +dV/dt was inscribed at 64 ± 5% of normalized equilibrium (diastatic) volume with an inter‐subject variation of 8%, and had a reduced intra‐subject (beat‐to‐beat) variation compared to conventional P‐V loops (9% vs. 13%, respectively; P < 0.005), thereby demonstrating load‐independent attributes. In contrast, VN at peak −dV/dt was inscribed at 81 ± 9% with an inter‐subject variation of 11%, and had no significant change in intra‐subject (beat‐to‐beat) variation compared to conventional P‐V loops (17% vs. 17%, respectively; P = 0.56), therefore failing to demonstrate load‐independent tendencies. Thus, the normalized P‐V loop advances the quest for load‐independent LV chamber properties. VN at the peak LV filling rate (≈sarcomere length at the peak sarcomere lengthening rate) manifests load‐independent properties. This novel method may help to elucidate and quantify new attributes of cardiac and cellular function. It merits further application in additional human and animal physiologic and pathophysiologic datasets.
Lindelöf P-spaces need not be Sokolov
Authors: Tkachuk Vladimir V. 
Published: March 2017

Abstract
We show that for every Lindelöf P-space a weaker version of the Sokolov property holds. Besides, if K is a scattered Eberlein compact space and X is obtained from K by declaring open all Gδ
-subsets of K, then X is monotonically Sokolov. The proof of this statement uses the fact that every Lindelöf subspace of a scattered Eberlein compact space must be σ-compact; this result seems to be interesting in itself. We also give an example of a Lindelöf P-space X such that Cp
(X) has uncountable extent. In particular, neither X nor Cp
(X) has the Sokolov property.
Crystal structure of 2,9-dibromo-1,10-phenanthroline, C12H6Br2N2
Authors: Zhang Yu , Wang Weizhou 
Published: March 2017

Abstract
C12H6Br2N2, orthorhombic, Pna21 (no. 33), a = 19.6816(9) Å, b = 4.6554(2) Å, c = 11.8795(6) Å, V = 1088.47(9) Å3, Z = 4, R
gt(F) = 0.043, wR
ref(F
2) = 0.107, T = 293 K.
Immutability, (Im)passibility and Suffering: Steps towards a “Psychological” Ontology of God
Authors: Pârvan Alexandra , McCormack Bruce L. 
Published: March 2017

SummaryWe call psychological ontology the attempt to think the being of God starting from his self-revelation in the individual life of Jesus Christ. We consider the ontological identity of Jesus Christ and the way the unity of his person is conceived crucial for understanding who this Christian God is, an understanding we take as the entry point into thinking what God is. We start from Augustine’s exegesis of the two names of God and Barth’s doctrine of election, and point out internal tensions in their respective views on divine immutability and (im)passibility, and how these connect with their concept of God and their understanding of the person of Christ. The unresolved problems in both thinkers lead us beyond their ontologies to argue that the divine-human relation that ontologically accounts for Jesus Christ’s unity is from eternity that which gives identity to the second person of the Trinity. Based on this claim we propose a reconceptualization of God’s immutability which is shown to be compatible with divine suffering and passibility.
On the Divine Preconscious Model of the Incarnation and concrete-nature Christology: A reply to James Arcadi
Authors: Ter Ern Loke Andrew 
Published: March 2017

SummaryIn a recent article published in NZSTh, James Arcadi offers an assessment of the Divine Preconscious Model of the Incarnation. Arcadi objects that, because I aver that this model runs on a concrete-nature account of natures, I am not able to maintain the full humanity of Christ. I argue that Arcadi’s objections are not compelling, and while I appreciate his intention to offer constructive feedback, I explain that his suggestions that I embrace a form of neo-Apollinarianism by adopting the abstract-nature perspective of natures are unmotivated and disadvantageous.
Vindicatio Mundi: The Concept of Mundane Life in Melanchthon’s Theological Endeavours seen from an Asian Perspective
Authors: Oseka Matthew 
Published: March 2017

SummaryThe present paper examines Melanchthon’s affirmative concept of mundane life which was distinct from a negative attitude to the world prevailing in the ancient and mediaeval Christian thought. Since Christianity emerged from Judaism, which adopted a positive outlook on mundane life reminiscent of the Reformation perspective, the Jewish affirmation of the world was discussed briefly in the present essay as well. The 16th-century Reformation vindicated the positive status of the world primarily through the idea of vocation and through the concept of education as the instrument for unfolding human nature and for equipping human beings for life in the community which was viewed by the Reformers as founded upon social bonds eventuating from a sense of the extended filial piety. In addition, the Reformation concept of mundane life was situated against the Asian tradition which in the present article was represented by Confucianism.