bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rolled‐Up Membranes from GaAs/AlOx Core‐Shell Nanowire Ensembles Through Natural Oxidation
Authors: Hashimoto Hidetoshi , Minehisa Keisuke , Nakama Kaito , Watanabe Kentaro , Nagashima Kazuki , Yanagida Takeshi , Ishikawa Fumitaro 
Published: October 2024

AbstractThe formation of rolled‐up cylindrical membranes stemming from the strain deformation‐induced delamination of a film‐like nanowires array composed of coalesced GaAs nanowires embedded in AlOx with a buried GaAs/AlAs core‐shell structure is reported. The delamination of the nanowires array film is driven by natural oxidation resulting from prolongated exposure to ambient atmosphere. Investigation of the structural characteristics of the nanowires in the array reveals an analytical description of the oxidation mechanism leading to the formation of the rolled‐up structures. The membrane can easily transfer by simply shaking off the surface membranes of the sample. The cylindrical membranes maintain the optical properties of the core GaAs nanowires surrounded by native oxide. The findings show the prospects for area‐saving and transferable semiconductor devices with advanced nanoscale optical functions.
Modified Biochar Materials From Eucalyptus globulus Wood as Efficient CO2 Adsorbents and Recyclable Catalysts
Authors: Zomorodbakhsh Shahab , Gonzalez Andreia C. S. , Cruz Inês G. , Piccirillo Giusi , Maria Teresa M. R. , Marques Inês S. , Peixoto Andreia F. , Gil João M. , Ferreira Fábio , Carrilho Rui M. B. 
Published: October 2024

AbstractHighly porous carbon materials derived from renewable resources constitute a promising and sustainable strategy regarding the enhancement of CO2 capture technologies. In this work, the valorization of Eucalyptus globulus wood, a forest invasive species present in European forests, is performed through its transformation in biochar. The deposition of nitrogen and different metals (aluminum, copper and chromium) onto biochar is performed, using the magnetron sputtering as a pioneering technique, to produce coated biochar nanoparticles with improved properties. The resultant modified biochar particles maintain a highly porous structure and present a remarkable CO2 adsorption capacity (up to 4.80 mmol g−1 for N@BC), which is attributed to the synergy of their large total surface area (527 m2 g−1) and microporosity (pore diameter = 21 Å), with a high content of nitrogen and oxygen heteroatom moieties (40.4% N, 11.4% O). Their application as heterogeneous bifunctional catalysts in CO2 cycloaddition to epichlorohydrin is performed, in the absence of any solvent or co‐catalyst, under moderate conditions (20 bar CO2, 120 °C), leading to good conversions (up to 58% conversion) and excellent selectivity for cyclic carbonates. Cu‐coated biochar is shown to be more stable than non‐modified material, being recycled and reused along 4 consecutive runs without loss of catalytic activity or selectivity.
All‐Ferroelectric Spiking Neural Networks via Morphotropic Phase Boundary Neurons
Authors: Kim Jangsaeng , Park Eun Chan , Shin Wonjun , Koo Ryun‐Han , Im Jiseong , Han Chang‐Hyeon , Lee Jong‐Ho , Kwon Daewoong 
Published: October 2024

AbstractArtificial neurons and synapses are crucial for efficiently implementing spiking neural networks (SNNs) in hardware. The distinct functional requirements of artificial neurons and synapses present significant challenges in the implementation of area‐ and energy‐efficient SNNs. This study reports an all‐ferroelectric SNN system through co‐optimization of material properties and device configurations using wafer‐scale atomic layer deposition. For the first time, a double‐gate (DG) morphotropic phase boundary‐based thin‐film transistor (MPBTFT) is utilized for a leaky integrate‐and‐fire (LIF) neuron. The DG MPBTFT‐based LIF neuron eliminates the need for capacitors and reset circuits, thereby enhancing area and energy efficiency. The DG configuration demonstrates various neuronal functions with high reliability. Co‐optimizing materials and devices significantly enhance the performance and functional versatility of artificial neurons and synapses. Meticulous material engineering facilitates the seamless co‐integration of DG MPBTFT‐based neurons, ferroelectric thin‐film transistor (TFT)–based synapses, and normal TFTs on a single wafer. All‐ferroelectric SNN systems achieved a high classification accuracy of 94.9%, thereby highlighting the potential of DG MPBTFT‐based LIF neurons for advanced neuromorphic computing.
A smart lab on a wearable microneedle patch with convolutional neural network‐enhanced colorimetry for early warning of syndrome of inappropriate antidiuretic hormone secretion
Authors: Xie Yuanting , Li Kaidi , Liu Jing , Zhou Ying , Zhang Chuangjie , Yu Yan , Wang Jianlong , Su Lei , Zhang Xueji 
Published: October 2024

AbstractFrequent nocturia‐induced nighttime visits aggravate falls in seniors, requiring synthetic antidiuretic drugs that risk the dangerous syndrome of inappropriate antidiuretic hormone secretion (SIADH), thus the detection of sodium ion and uric acid alterations during treatment is obligatory for drug‐safe management. Herein, we design a convolutional neural network (CNN)‐enhanced smart wearable microneedle array‐based colorimetric (WMNC) sensor to independently detect in vivo interstitial fluid (ISF) sodium ions and uric acid alterations. The WMNC sensor is composed of a vacuum tube‐driven microneedle array patch and a built‐in colorimetric sensing paper, enabling an efficient ISF extraction and rapid colorimetric assay. Furthermore, leveraging self‐designed CNNs, the WMNC sensor efficiently eliminates the influence of ambient light on colorimetric outcomes, facilitating a rapid and accurate colorimetric result classification. This study provides an ISF‐based rapid, intuitionistic, user‐friendly, wearable point‐of‐care technique for the elderly suffering from nocturia in monitoring their health status for early warnings of SIADH.
Divergent Sc(OTf)3‐Catalyzed Tandem Cyclization of o‐Hydroxyphenyl Enaminones with 1,3,5‐Triazinanes: Access to C3‐Aminomethyl Chromones and Tetrahydropyrimidines
Authors: Han Siyang , Fang Chengcheng , Li Sifeng , Mo Xiaoye , Xu Yingqian , An Baigang , Cheng Bin 
Published: October 2024

AbstractA Sc(OTf)3‐catalyzed tandem cyclization reaction of o‐hydroxyphenyl enaminones with 1,3,5‐triazinanes has been developed to generate two distinct annulated products in moderate to good yields, which is dominated by the electronic characteristics of the 1,3,5‐triazinanes. The 1,3,5‐triaryl‐1,3,5‐triazinane reacted as C−N synthon to produce C3‐aminomethyl chromone, while the 1,3,5‐trialkyl‐1,3,5‐triazinane acted as C−N−C−N synthons to deliver N,N‐dialkyl tetrahydropyrimidine with a free hydroxyl group.
NHC‐Catalyzed [3+3] Cycloaddition of 2‐(acetoxymethyl)buta‐2,3‐dienoates with 1 C,3O‐bisnucleophiles
Authors: Cao Wei , Zhang Kai , Yu Chenxia , Yao Changsheng 
Published: October 2024

AbstractDiverse transformations of allenoates catalyzed by Lewis bases have emerged as a powerful platform for generating new chemical entities in organic synthesis. Herein, an N‐heterocyclic carbene (NHC) catalyzed [3+3] cyclization of 2‐(acetoxymethyl)buta‐2,3‐dienoates with 1 C,3O‐bisnucleophiles has been developed. This approach provides a facile method to synthesize highly functionalized 4H‐pyran derivatives with a broad substrate scope (31 examples, up to 83 % yield).
Modifiable dementia risk factors associated with objective and subjective cognition
Authors: Rosická Anna Marie , Teckentrup Vanessa , Fittipaldi Sol , Ibanez Agustin , Pringle Andrew , Gallagher Eoghan , Hanlon Anna Kathleen , Claus Nathalie , McCrory Cathal , Lawlor Brian , Naci Lorina , Gillan Claire M. 
Published: October 2024

AbstractINTRODUCTIONEarly detection of both objective and subjective cognitive impairment is important. Subjective complaints in healthy individuals can precede objective deficits. However, the differential associations of objective and subjective cognition with modifiable dementia risk factors are unclear.METHODSWe gathered a large cross‐sectional sample (N = 3327, age 18 to 84) via a smartphone app and quantified the associations of 13 risk factors with subjective memory problems and three objective measures of executive function (visual working memory, cognitive flexibility, model‐based planning).RESULTSDepression, socioeconomic status, hearing handicap, loneliness, education, smoking, tinnitus, little exercise, small social network, stroke, diabetes, and hypertension were all associated with impairments in at least one cognitive measure. Subjective memory had the strongest link to most factors; these associations persisted after controlling for depression. Age mostly did not moderate these associations.DISCUSSIONSubjective cognition was more sensitive to self‐report risk factors than objective cognition. Smartphones could facilitate detecting the earliest cognitive impairments.Highlights
Smartphone assessments of cognition were sensitive to dementia risk factors.
Subjective cognition had stronger links to most factors than did objective cognition.
These associations were not fully explained by depression.
These associations were largely consistent across the lifespan.
Chemisch stabile Diazopeptide als selektive Sonden für Cysteinproteasen in lebenden Zellen
Authors: Wahl Juliane , Ahsanullah  , Zupan Hana , Gottschalk Franziska , Nerlich Andreas , Arkona Christoph , Hocke Andreas C. , Keller Bettina G. , Rademann Jörg 
Published: October 2024

AbstractVon Diazopeptiden wurden schon früher berichtet, sie haben aber aufgrund ihrer hohen Reaktivität bis heute kein breites Einsatzgebiet gefunden. Wir berichten hier von der Herstellung, den Eigenschaften und Anwendungen chemisch stabiler interner Diazopeptide. Peptidylphosphoranylidenester und ‐amide reagieren mit Triflylazid hauptsächlich zu neuartigen 4,5‐disubstituierten 1,2,3‐Triazolylpeptiden. Nonaflylazid hingegen liefert Diazopeptide, die als Amide bei pH 1–14 und als Ester bei pH 1–8 chemisch stabil sind. Somit sind durch Festphasenpeptidsynthese hergestellte Diazopeptide auch während der finalen Entschützung mit 95 % Trifluoressigsäure stabil. Diazopeptide mit der Erkennungssequenz von Caspase‐3 wurden als spezifische, kovalente und irreversible Inhibitoren dieses Enzyms bei niedrigen nanomolaren Konzentrationen identifiziert. Ein fluoreszierendes Diazopeptid drang in lebende Zellen ein und ermöglichte mikroskopische Visualisierung und Quantifizierung von Apoptose durch Durchflusszytometrie. Diazopeptide stellen somit eine neue Klasse aktivitätsbasierter Sonden und Enzyminhibitoren zum Einsatz in der chemischen Biologie und medizinischen Chemie dar.
Convenient synthesis of phthalonitrile‐containing mono‐benzoxazines with exceptional thermal stability and improved curing activity
Authors: Zhang Shuai , Wang Yike , Wang Huachun , Luo Yifei , Yang Ao , Ye Jiajia , Huang Yumin , Fu Ju 
Published: October 2024

AbstractSimple synthesis and high performance are eternal pursuit for polymers. To lower the curing temperature, lower the melt viscosity and improve the processability of high performance phthalonitrile resins, a solvent‐free method was applied to synthesize three from different phenols. Their chemical structure was confirmed by FTIR and NMR spectra, the curing behavior was investigated by DSC and rheology. It was found that the polymerization of phthalonitrile groups could be effectively promoted by benzoxazine moieties and the curing temperature of phthalonitrile groups dropped to around 240°C. Consequently, owing to the high curing reactivity, polymers obtained at relatively low curing temperature possessed high crosslinking density and extremely high thermal stability. P‐apn‐200, which was cured at 200°C, showed 5 wt% weightloss temperature (Td5) of 472°C and char yield (Yc) of 75.77% at 800°C. Moreover, the polymers obtained after curing at 280°C showed superior dimensional stability, CN‐apn‐280 showed extremely low linear expansion coefficient (CTE) of 10.7 ppm/°C. And mP‐apn‐280 showed HR capacity of 3.99 J/g‧K, peak HRR of 4.0 W/K and total HR of 0.8 kJ/g.
Dynamics of Reliance on Algorithmic Advice
Authors: Gill Andrej , Gillenkirch Robert M. , Ortner Julia , Velthuis Louis 
Published: October 2024

ABSTRACTThis study examines the dynamics of human reliance on algorithmic advice in a situation with strategic interaction. Participants played the strategic game of Rock–Paper–Scissors (RPS) under various conditions, receiving algorithmic decision support while facing human or algorithmic opponents. Results indicate that participants often underutilize algorithmic recommendations, particularly after early errors, but increasingly rely on the algorithm following successful early predictions. This behavior demonstrates a sensitivity to decision outcomes, with asymmetry: rejecting advice consistently reinforces rejecting advice again while accepting advice leads to varied reactions based on outcomes. We also investigate how personal characteristics, such as algorithm familiarity and domain experience, influence reliance on algorithmic advice. Both factors positively correlate with increased reliance, and algorithm familiarity significantly moderates the relationship between outcome feedback and reliance. Facing an algorithmic opponent increases advice rejection frequencies, and the determinants of trust and interaction dynamics differ from those with human opponents. Our findings enhance the understanding of algorithm aversion and reliance on AI, suggesting that increasing familiarity with algorithms can improve their integration into decision‐making processes.
Education and ideological polarisation: Cross‐country evidence and recommendations for higher education
Authors: Lee Ines , Tipoe Eileen 
Published: October 2024

AbstractIn many developed countries, disagreement on important policy issues between groups with different social identities (‘ideological polarisation’) is increasing. In professional settings, these disagreements undermine cooperation and trust between employees, which negatively affects work relationships and managerial decision‐making. We investigate whether people with more education tend to express attitudes that are more (or less) polarised. Using nationally representative data for 18 OECD countries from 2010 to 2018, we find that in most countries, ideological polarisation between liberals (political left) and conservatives (political right) on three key policy issues (income inequality, immigration and gay rights) increases with education. This ‘education–polarisation’ gradient varies across countries, is strongest in the United States and is linked to stronger alignment between political ideology and non‐political values, and greater internet use among more‐educated individuals. This finding can explain why polarisation can persist and even increase, despite the growing availability of information. We conclude with implications and recommendations for higher education.
Bone and periosteum protein analysis via tandem mass tag quantitative proteomics in pediatric patients with osteomyelitis
Authors: Wu Xinwu , Chen Peisheng , Huang Dianhua , Pan Yuchen , Chen Shunyou 
Published: October 2024

AbstractBone healing is crucial in managing osteomyelitis after fracture fixation. Understanding the mechanism of extensive callus formation in pediatric osteomyelitis is highly important. This study aims to analyze bone and periosteum samples from pediatric patients to elucidate the essential processes involved in callus formation during osteomyelitis. The study included eight patients from our hospital: four with positive microbial culture who underwent osteomyelitis debridement and four who had osteotomy surgery as contral. We used tandem mass tag quantitative proteomics to investigate proteomic changes in bone and periosteum tissues obtained from these patients. Differential expression proteins were analyzed for their pathways through Gene Ontology (GO) annotation, GO enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and protein–protein interaction networks. A total of 4737 proteins were successfully identified. About 2224 differentially expressed proteins were detected in the bone tissues group and periosteum tissues group. Among the differentially expressed proteins, 10 protein genes in the bone group were associated with inflammation and osteogenesis, while in the periosteum group were nine. Cytochrome b‐245, beta polypeptide (CYBB), nicotinamide phosphoribosyltransferase (NAMPT), tissue inhibitor of metalloproteinases 1 (TIMP‐1), Raf‐1 proto‐oncogene, serine/threonine kinase (RAF‐1), RELA proto‐oncogene, NF‐KB subunit (RELA), and sphingomyelin synthase 2 (SGMS2) may play an important role in callus formation in patients with osteomyelitis. This study provides novel clues for understanding callus formation in pediatric patients with osteomyelitis.
Navigating tensions of sustainable supply chains in times of multiple crises: A systematic literature review
Authors: Kareem Sunny , Fehrer Julia A. , Shalpegin Timofey , Stringer Christina 
Published: October 2024

AbstractThe challenges posed by multi‐crisis environments, such as pandemics and geopolitical uncertainties, create significant opportunities for supply chains (SC) to enhance their sustainability, resilience, and agility, thereby developing a strategic advantage. However, seizing these opportunities is not without its challenges; critical tensions inevitably arise. This paper, based on a systematic review of 287 SC studies, identifies and discusses five key tensions: (1) increased trade‐offs between sustainability and efficiency; (2) competing priorities between SC sustainability and resilience; (3) mismatched sustainability expectations causing stakeholder pressure; (4) conflicting demands between global and sustainable operations; and (5) unintended consequences of technological innovation, disadvantaging stakeholders with limited resources and capabilities. To mitigate these tensions while leveraging on the opportunities, the study proposes several strategic pathways, including adopting circular economy principles, optimizing inventory and distribution management, employing holistic measurement and forecasting, balancing risk‐hedging with proactive risk management, fostering inclusive stakeholder engagement, balancing globalization and regionalization, and integrating advanced digital technologies alongside with SC ecosystem wide change management. These strategies offer practical guidance for building sustainable and crises‐ready SCs and set the stage for an extensive research agenda to further explore SC sustainability in multi‐crisis environments.
A Spectroscopic Study on the Amyloid‐β Interaction with Clicked Peptide‐Porphyrin Conjugates: a Vision Toward the Detection of Aβ Peptides in Aqueous Solution
Authors: Tosto Rita , Zimbone Stefania , Sabatino Giuseppina , Di Natale Giuseppe , Laura Giuffrida Maria , Flora Tomasello Marianna , Lanzanò Luca , Campagna Tiziana , Covaceuszach Sonia , Vecchio Graziella , Pappalardo Giuseppe 
Published: October 2024

AbstractAlzheimer's disease (AD) is a multifactorial form of dementia mainly affecting people in the elderly, but no effective cure is available. According to the amyloid hypothesis the aggregation of Amyloid‐β (Aβ) into oligomeric toxic species is believed to concur with the onset and progression of the disease heavily. By using a click chemistry approach, we conjugated a suitable designed peptide sequence to a metalloporphyrin moiety to obtain three hybrid peptide systems to be studied for their interaction with Amyloid‐β peptides. The aim is to get new tools for the diagnosis and therapy in AD. The results described in this study, which were obtained through spectroscopic techniques (UV‐Vis, CD, bis‐Ans and intrinsic porphyrin Fluorescence), Microfluidics (GCI) and cell biology (MTT, Live cell imaging and flow cytometry), reveal interesting features about the structure‐activity relationships connecting these conjugates with the interaction with Aβ, as well as on their potential use as sensing systems. In our opinion the data reported in this paper make the porphyrin‐peptide conjugates highly compelling for further exploration as spectroscopic probes to detect Aβ biomarkers in biological fluids.
Mono‐Palmitoyl‐N‐Alkylurea Ligands as Specific Activators of Human Toll‐Like Receptor 2/6 Heterodimer
Authors: Isendoorn Marjolein M. E. , Castello Giulia , Koç Çağla , Meeuwenoord Nico , Codée Jeroen D. C. , Ossendorp Ferry , Filippov Dmitri V. 
Published: October 2024

AbstractLigands for Toll‐like‐receptor 2 (TLR2) have demonstrated significant potential as immune‐stimulating components in synthetic vaccines. Activation of TLR2 relies on the formation of dimeric complexes with either TLR1 or TLR6 and the nature of these dimers can impact therapeutic outcomes. The lipopeptide‐based TLR2 ligands Pam3CysSK4 and Pam2CysSK4 have been extensively studied, and their recognition by different TLR‐receptor heterodimers, TLR2/TLR1 and TLR2/TLR6, respectively, has been established. However, the high lipophilicity of these ligands, containing multiple palmitoyl residues, can result in solubility issues when used as vaccine adjuvants. To address this, we previously synthesized a less lipophilic ligand containing a single palmitoyl chain called mini‐UPam, which effectively stimulates human moDC maturation. We here probe the receptor‐dimer specificity of several mini‐Upam derivatives and reveal that these mini‐UPam are hTLR2/TLR6 selective ligands and that the introduction of longer urea alkyl chains does not shift the binding specificity to hTLR2/TLR1 heterodimers, in contrast to their Pam2CysSK4 and Pam3CysSK4 counterparts, pointing to a different binding mode of the UPam ligands.
Management of iatrogenic ascending aortic dissection after percutaneous intervention of chronic total occlusion
Authors: Safdar Ahmad , Young Laura , Khatri Jaikirshan 
Published: October 2024

AbstractBackgroundThis study highlights the prevalence and conservative management strategies of iatrogenic ascending aortic dissection after percutaneous intervention (PCI) of chronic total occlusion (CTO).MethodsRetrospective analysis on patients who underwent CTO PCI from one medical center from 2020 to 2022 was performed by two operators. Data was obtained from the Prospective Global Registry for the Study of CTO database.ResultsOut of 318 patients, there were six reported cases of iatrogenic ascending aortic dissection. The causes of dissection included guiding catheter trauma, antegrade injection, two retrograde injection, and two cases of balloon rupture after lithotripsy. IVUS‐guided stenting of the coronary back to the origin to seal the entry of the dissection flap occurred in two patients. All patients had a conservative management approach. No patient had to undergo urgent surgery.ConclusionWhile the incidence remains rare, complications, including aortic dissection, are more frequent in CTO PCI as compared to non‐CTO PCI. IVUS can be used to complete coronary intervention so long as the patient remains clinically and hemodynamically stable. Patients should have formal imaging with either transesophageal echocardiogram or computed tomography angiography. The outcomes of patients who experience iatrogenic aortic dissection during CTO PCI with stable coronary disease seem to be better than in patients with acute coronary syndrome.