bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spiritual care by nurses in curative cancer care: Protocol for a national, multicentre, mixed method study
Authors: Groot Marieke , Ebenau Anne F. , Koning Helen , Visser Anja , Leget Carlo , van Laarhoven Hanneke W.M. , van Leeuwen René , Ruben Riet , Wulp Marijke , Garssen Bert 
Published: May 2017

AbstractAimTo gain insight into the quantity and quality of spiritual care provided by nurses in curative cancer care, from the perspectives of both patients and nurses.BackgroundCancer causes patients to suffer from diverse symptoms related to their illness. Nurses play an important role in the care for people with cancer. Next to paying attention to physical and psychosocial needs, caring for spiritual needs of patients also belongs to good nursing. Most of the research concerning spirituality and spiritual care in relation to cancer has focused on palliative care.DesignA mixed methods design will be used in two sub‐phases. First, we will conduct semi‐structured interviews with 72–90 patients coming from nine hospitals. Subsequently, approximately the same number of nurses working on oncology wards of these hospitals will be interviewed.MethodsWe meticulously composed both interview guides so that only near the end of the interview explicit terms like spirituality and spiritual care are explicitly mentioned. Until that point, we will use other words to define the concepts. Next to the interviews, demographics, answers to some statements and several questionnaires will be gathered. Content analysis supported by DEDOOSE will be used to answer the research questions.DiscussionThe insight we will gain in this study enables us to compare experiences from the perspective of both patients and nurses. This can also provide us with suggestions for the improvement of nursing care for people with cancer who are treated with curative intent, a topic until now hardly addressed.
Use of guideline‐recommended adjuvant therapies and survival outcomes for people with colorectal cancer at tertiary referral hospitals in South Australia
Authors: Adelson Pamela , Fusco Kellie , Karapetis Christos , Wattchow David , Joshi Rohit , Price Timothy , Sharplin Greg , Roder David 
Published: May 2017

AbstractRationale, aims and objectivesAdjuvant care for colorectal cancer (CRC) has increased over the past 3 decades in South Australia (SA) in accordance with national treatment guidelines. This study explores the (1) receipt of adjuvant therapy for CRC in SA as related to national guideline recommendations, with a focus on stage C colon and stage B and C rectal cancer; (2) timing of these adjuvant therapies in relation to surgery; and (3) comparative survival outcomes.MethodsData from the SA Clinical Cancer Registry from 4 tertiary referral hospitals for 2000 to 2010 were examined. Patterns of care were compared with treatment guidelines using multivariable logistic regression. Disease‐specific survivals were calculated by treatment pathway.ResultsFour hundred forty‐three (60%) patients with stage C colon cancer and 363 (46%) with stage B and C rectal cancer received guideline‐recommended care. While an overall increase in proportion receiving adjuvant care was not evident across the study period, the proportion having neoadjuvant care increased substantially. Older age was an independent predictor of not receiving adjuvant care. Patients with stage C colon cancer who received recommended adjuvant care had a higher 5‐year survival than those not receiving this care, ie, 71.2% vs 53.2%. Similarly adjuvant therapy was associated with better outcomes for stage C rectal cancers. The median time for receiving adjuvant care was 8 weeks.ConclusionsSurvival was better for stage C CRC treated according to guidelines. Adjuvant care should be provided except where clear contraindications present. Other possible contributors to guideline adherence warranting additional investigation include co‐morbidity status, multidisciplinary team involvement, and choice.
The Ciliary ProteinIFT57 in the Macronucleus ofParamecium
Authors: Shi Lei , Koll France , Arnaiz Olivier , Cohen Jean 
Published: May 2017

AbstractThe intraflagellar transportIFT57 protein is essential for ciliary growth and maintenance. Also known asHIPPI, humanIFT57 can be translocated to the nucleus via a molecular partner of the Huntingtin, Hip1, inducing gene expression changes. InParamecium tetraurelia, we identified fourIFT57 genes forming two subfamiliesIFT57A/B andIFT57C/D arising from whole genome duplications. The depletion of proteins of the two subfamilies induced ciliary defects andIFT57A andIFT57C localized in basal bodies and cilia. We observed thatIFT57A, but notIFT57C, is also present in the macronucleus and able to traffic toward the developing anlage during autogamy. Analysis of chimericIFT57A‐IFT57C‐GFP‐tagged proteins allowed us to identify a region ofIFT57A necessary for nuclear localization. We studied the localization of the uniqueIFT57 protein ofParamecium caudatum, a species, which diverged fromP. tetraureliabefore the whole genome duplications. TheP. caudatumIFT57C protein was excluded from the nucleus. We also analyzed whether the overexpression ofIFT57A inParameciumcould affect gene transcription as the human protein does in HeLa cells. The expression of some genes was indeed affected by overexpression ofIFT57A, but the set of affected genes poorly overlaps the set of genes affected in human cells.
Muscular thickness of lower esophageal sphincter and therapeutic outcomes in achalasia: A prospective study using high‐frequency endoscopic ultrasound
Authors: Li Shih‐Wei , Tseng Ping‐Huei , Chen Chien‐Chuan , Liao Wei‐Chih , Liu Kao‐Lang , Lee Jang‐Ming , Lee Yi‐Chia , Chuah Seng‐Kee , Wu Ming‐Shiang , Wang Hsiu‐Po 
Published: May 2017

AbstractBackground and AimPatients with achalasia typically have thicker lower esophageal sphincter muscles, which can affect the distensibility of the esophagogastric junction. We aimed to assess whether these muscular features, measured using high‐frequency endoscopic ultrasound, affect treatment outcomes.MethodsConsecutive adult patients with suspected achalasia were enrolled prospectively. They underwent a comprehensive diagnostic workup, including endoscopic ultrasound. The thickness of the lower esophageal sphincter, including the internal circular and outer longitudinal muscles, was measured using a 12‐MHz ultrasonic miniprobe. Follow‐up was performed at 1 month and then at 6‐month intervals, after treatment. Treatment response was defined as a reduction in Eckardt score to ≤3 or an improvement in the height of the timed barium esophagogram of ≥50%.ResultsOf the 29 patients who received pneumatic dilatation, all but one (96.6%) exhibited a good short‐term treatment response. At an average follow‐up time of 18.5 (12–55.5) months, patients who had a mid‐term recurrence after pneumatic dilatation had a significantly thicker outer longitudinal muscle (1.8 [1.5–1.8] vs 0.9 [0.8–1.7] mm, P = 0.036), but not internal circular muscle (2.0 [1.9–2.5] vs 2.1 [1.2–2.7] mm, P = 0.874) or total lower esophageal sphincter (3.7 [3.5–4.4] vs 3.6 [2.0–4.1] mm, P = 0.362). Patients with an outer longitudinal muscle ≥1.3 mm thick had a significantly lower mid‐term remission rate than others (36.3% vs 100%, P = 0.01).ConclusionThickening of the outer longitudinal muscle at the lower esophageal sphincter is associated with poor mid‐term treatment outcomes for achalasia patients treated with pneumatic dilatation.
Direct health‐care cost utilization in Hong Kong inflammatory bowel disease patients in the initial 2 years following diagnosis
Authors: Mak Lung‐Yi , Ng Siew C , Wong Irene O L , Li Michael K K , Lo F H , Wong Marc T L , Leung C M , Tsang Steven W C , Chan K H , Sze S F , Shan Edwin H S , Lam Belsy C Y , Hui Aric J , Hung Ivan F N , Leung Wai K 
Published: May 2017

AbstractBackground and AimThere are scanty data on the health‐care utilization from Asia where the incidence of inflammatory bowel disease (IBD) is rising rapidly. We aim to determine the direct health‐care costs in the first 2 years of diagnosis in an IBD cohort from Hong Kong and the factors associated with high cost outliers.MethodsThis is a retrospective cohort study that included patients newly diagnosed with IBD in a territory‐wide IBD registry. Patients' clinical information, hospitalization records, investigations, and IBD treatments were retrieved for up to 2 years following diagnosis of IBD.ResultsFour hundred and thirty‐five newly diagnosed IBD patients were included: 198 with Crohn's disease and 237 with ulcerative colitis. Total direct medical expenditure for this cohort 2 years after the IBD diagnosis was $7 072 710: hospitalizations (33%), 5‐aminosalicylic acid (23%), imaging and endoscopy (17%), outpatient visits (10%), surgery (8%), and biologics (6%). Mean direct medical costs per patient‐year were significantly higher for Crohn's disease ($9918) than ulcerative colitis ($6634; P, 0.001). The total direct health‐care cost decreased significantly after transition to the second year (P < 0.01). High cost (> 90th percentile) outliers were associated with surgery (OR 7.1, 95% CI 2.9–17.2) and low hemoglobin on presentation (OR 0.83, 95% CI 0.70–0.96).ConclusionsHospitalization and 5‐aminosalicylic acid usage accounted for 56% of total direct medical costs in the first 2 years of our newly diagnosed IBD patients. Direct health‐care costs were higher in the first year compared with the second year of diagnosis. Surgery and low hemoglobin on presentation were associated with high cost outliers.
A focus on reward in anorexia nervosa through the lens of the activity‐based anorexia rodent model
Authors: Foldi C. J. , Milton L. K. , Oldfield B. J. 
Published: May 2017

AbstractPatients suffering anorexia nervosa (AN) become anhedonic, unable or unwilling to derive normal pleasures and tend to avoid rewarding outcomes, most profoundly in food intake. The activity‐based anorexia model recapitulates many of the pathophysiological and behavioural hallmarks of the human condition, including a reduction in food intake, excessive exercise, dramatic weight loss, loss of reproductive cycles, hypothermia and anhedonia, and therefore it allows investigation into the underlying neurobiology of anorexia nervosa. The use of this model has directed attention to disruptions in central reward neurocircuitry, which may contribute to disease susceptibility. The purpose of this review is to demonstrate the utility of this unique model to provide insight into the mechanisms of reward relevant to feeding and weight loss, which may ultimately help to unravel the neurobiology of anorexia nervosa and, in a broader sense, the foundation of reward‐based feeding.
A willingness to go there: Nurses and spiritual care
Authors: Minton Mary E. , Isaacson Mary J. , Varilek Brandon Michael , Stadick Jessica L. , O'Connell‐Persaud Shannon 
Published: May 2017

Aims and objectivesTo describe rural and urban palliative/hospice care nurses’ communication strategies while providing spiritual care for patients and families at end of life.BackgroundNurses aim to provide holistic care consisting of physical, psychological and spiritual components. However, it is well documented that spiritual care is largely missing from nursing care. Internationally, spiritual care is a growing topic of interest, yet many nurses feel unprepared to deliver spiritual care.DesignThis qualitative study used Braun and Clarke's thematic analysis method.MethodsAs part of a larger multimethod study, this study shares the narrative descriptions from 10 experienced palliative/hospice care nurses. Individual, face‐to‐face interviews were conducted and lasted 45–60 minutes. Each interview started with the same lead‐in questions, was audio‐recorded and was transcribed verbatim. The research team used an inductive analysis approach and met several times reviewing and analysing the detected themes until reaching consensus.ResultsThe primary theme, sentience includes the capacity to act, a willingness to enter into the unknown and the ability to have deep meaningful conversations with patients regardless of the path it may yield. Subthemes include: (i) Willingness to Go There, (ii) Being in “A” Moment and (iii) Sagacious Insight.ConclusionNurses are integral in the provision of spiritual care for patients/families across the lifespan and at end of life. Nurses must feel confident and competent before they are willing to enter uncomfortable spaces with patients/families. Nursing curriculum must include purposeful engagement and focused debriefing in spiritual assessment and care.Relevance to clinical practiceThere is a dire need to prepare undergraduate and graduate students to assess and support a patient's spiritual needs. Addressing spiritual care content as a clinical and educational priority will promote a patient‐centred approach for spiritual care and can further shape nursing curricula, policies, guidelines and assessment tools.
Molecular identification of diverse ‘Candidatus Phytoplasma’ species associated with grapevine decline in Iran
Authors: Ghayeb Zamharir Maryam , Paltrinieri Samanta , Hajivand Shokrollah , Taheri Mahdi , Bertaccini Assunta 
Published: May 2017

AbstractGrapevine (Vitis vinifera) is one of the most important fruits in Iran where the provinces of Qazvin, Lorestan and Markazi are main producers. During 2013–2015, vineyards located in these provinces were surveyed to verify the presence of phytoplasma. The sample collection was based on symptomatology including decline, leaf yellowing and shortening of internodes. Total DNA was extracted from symptomatic and symptomless grapevine samples and used in nested‐polymerase chain reaction (PCR) assays with phytoplasma ribosomal primers (P1/Tint followed by R16F2n/R2, R16mF1/mR1, R16(I)F1/R1 or 6R758f/16R1232r). Nested‐PCR products were obtained only for symptomatic samples while samples from symptomless plants yielded no PCR products. Restriction fragment length polymorphism (RFLP) analyses with Tru1I, TaqI and Tsp509I and direct sequencing of amplicons followed by phylogenetic analyses indicated the presence of ‘Candidatus Phytoplasma fraxini’, ‘Ca. P. aurantifolia’, ‘Ca. P. solani’ and ‘Ca. P. phoenicium’‐related strains. In Marzaki province, there ‘Ca. P. aurantifolia’ strains were mainly detected, while in the other two provinces, all the four ‘Candidatus species’ were identified with the prevalence of ‘Ca. P. solani’‐related strains. In both provinces in one case, mixed phytoplasma infection was also detected by RFLP analyses. The presence of different phytoplasmas in positive samples indicates great phytosanitary significance due to grapevine economic importance for country. Grapevine phytoplasma infection represents a threat for other crops suggesting grapevine as alternative host species for the phytoplasmas already reported in Iran, while the ‘Ca. P. fraxini’ is for the first time identified in Iran.
Mental health literacy in korean older adults: A cross‐sectional survey
Authors: Kim Y. S. , Lee H. Y. , Lee M. H. , Simms T. , Park B. H. 
Published: May 2017

Accessible summaryWhat is known on the subject?

Mental health literacy is a fairly new concept, first introduced in 1997. It refers to what people know and believe about mental health disorders. People's knowledge and beliefs help them to recognize, manage and prevent mental disorders.

Generally, older adults have lower health literacy compared to young and middle‐aged adults.

What this study adds to existing knowledge?

This is the first study on the mental health literacy of Korean older adults.

This study looks beyond peoples’ ability to recognize mental health disorders and their opinions about them. It identifies factors that are associated with mental health literacy (level of education and social support, the number of people in one's social circles and how individuals rate their health).

What are the implications for practice?

Older adults might get more out of mental health literacy programmes in group or social settings.

Programmes that use older adult peer educators/supporters, such as the “older people's champions” of the Healthy Passport programme in England, might make the programmes more effective.

Mental health campaigns, such as Australia's beyondblue, might increase mental health literacy of older adults.

AbstractIntroductionKorea is experiencing rapid population ageing, spurring an increased need for mental health services for the elderly. Approximately one‐third of Korean older adults experience depressive symptoms, and Korea has the highest elder suicide rate among 34 developed nations. Mental health literacy is an important component of promoting mental health, yet studies on the concept have been conducted in few countries.AimThis study examines the level of mental health literacy among Korean older adults and identifies factors associated with their mental health literacy.MethodA cross‐sectional survey was conducted with 596 community‐dwelling Korean adults aged 65 and older. Andersen's Behavioral Model of Health Services Use framed the study.ResultsOverall, participants displayed low levels of mental health literacy. They had difficulty recognizing their mental health issues and had limited knowledge about self‐help strategies. Mental health literacy was positively associated with education, social support, social network and health status.Discussion and ImplicationsThis study highlights a need for efforts to increase mental health literacy among Korean older adults. Strategies that have the potential to empower this population to proactively attend to their mental health include community‐based education and national mental health campaigns.
Safety and efficacy of sofosbuvir‐based direct‐acting antiviral regimens for hepatitis C virus genotypes 1‐4 and 6 in Myanmar: Real‐world experience
Authors: Hlaing N. K. T. , Mitrani R. A. , Aung S. T. , Phyo W. W. , Serper M. , Kyaw A. M. M. , Bwa A. H. , Win K. M. , Reddy K. R. 
Published: May 2017

SummaryThis open‐label, clinical experience investigated the safety and efficacy of direct‐acting antiviral (DAA) hepatitis C virus (HCV) therapy in Myanmar; 344 patients completed treatment between June 2015 and May 2016. Patients with HCV genotypes 1‐4 and 6 received one of four treatments: (i) Peg‐interferon (PEG‐IFN)+sofosbuvir (SOF)+ribavirin (RBV) for 12 weeks, (ii) SOF+RBV for 24 weeks, (iii) ledipasvir (LDV)+SOF for 12 weeks or (iv) daclatasvir (DCV)+SOF+RBV for 12 or 24 weeks. Genotype 3 was most common (n=133, 38.7%), followed by genotype 6 (n=122, 35.5%) and genotype 1 (n=86, 25%). Overall, 91% of patients achieved sustained virologic response (SVR); 99% in group 1, (n=148/149), 90% in group 2 (n=95/106), 78% in group 3 (n=65/83) and 100% in group 4 (n=6/6). In group 3, SVR rates were 96.8% in genotype 1 (n=30/31) and 64.1% in genotype 6 (n=25/39). Multivariable regression analysis identified advanced fibrosis (F3‐4) (OR=.16 CI: 0.05‐0.57, P=.005), genotype 6 (OR=.35, CI: 0.16‐0.79, P=.012) and diabetes (OR=.29, CI: 0.12‐0.71, P=.007) as negative independent predictors of response. Adverse events were mild with all‐oral therapy. Conclusion: DAA therapy ±PEG‐IFN achieved high SVR rates. Genotype 6 patients had a low SVR to 12 weeks of LDV and SOF raising the need for other regimens, RBV or longer treatment duration in this population.
Transferability of Human Capital and Immigrant Assimilation: An Analysis for Germany
Authors: Basilio Leilanie , Bauer Thomas K. , Kramer Anica 
Published: May 2017

AbstractThis paper investigates the transferability of human capital from various countries to Germany and the contribution of imperfect human capital portability to the explanation of the immigrant‐native wage gap. Our results reveal that, overall, education and, in particular, labor market experience accumulated in the home countries of the immigrants receive significantly lower returns than human capital obtained in Germany. We further find evidence for heterogeneity in the returns to human capital of immigrants across countries. Finally, imperfect human capital transferability appears to be a major factor in explaining the wage differential between natives and immigrants.
Small‐cost asymptotics for long‐term growth rates in incomplete markets
Authors: Melnyk Yaroslav , Seifried Frank Thomas 
Published: May 2017

AbstractThis paper provides a rigorous asymptotic analysis of long‐term growth rates under both proportional and Morton–Pliska transaction costs. We consider a general incomplete financial market with an unspanned Markov factor process that includes the Heston stochastic volatility model and the Kim–Omberg stochastic excess return model as special cases. Using a dynamic programming approach, we determine the leading‐order expansions of long‐term growth rates and explicitly construct strategies that are optimal at the leading order. We further analyze the asymptotic performance of Morton–Pliska strategies in settings with proportional transaction costs. We find that the performance of the optimal Morton–Pliska strategy is the same as that of the optimal one with costs increased by a factor of . Finally, we demonstrate that our strategies are in fact pathwise optimal, in the sense that they maximize the long‐run growth rate path by path.
iConnect CKD – virtual medical consulting: A web‐based chronic kidney disease, hypertension and diabetes integrated care program
Authors: Katz Ivor J , Pirabhahar Saiyini , Williamson Paula , Raghunath Vishwas , Brennan Frank , O'Sullivan Anthony , Youssef George , Lane Cathie , Jacobson Gary , Feldman Peter , Kelly John 
Published: May 2017

AbstractAimsChronic kidney disease patients overwhelm specialist services and can potentially be managed in the primary care (PC). Opportunistic screening of high risk (HR) patients and follow‐up in PC is the most sustainable model of care. A ‘virtual consultation’ (VC) model instead of traditional face to face (F2F) consultations was used, aiming to assess efficacy and safety of the model.MethodsSeventy patients were recruited from PC sites and hospital clinics and followed for 1 year. The HR patients (eGFR < 30 mL/min/1.73m2 +/− albuminuria >30 mg/mmol/L) were randomized to either VC or F2F. Patients were monitored in 6 monthly follow‐up cycles by a Clinical Nurse Specialist. The specialist team provided virtual or clinical support and included a Nephrologist, Endocrinologist, Cardiologist and Renal ‘Palliative’ Supportive Care.ResultsSixty one (87%) patients were virtually tracked or consulted with 14 (23%) being HR. At 12 months, there was no difference in outcomes between VC and F2F patients. All patients were successfully monitored. General practitioners reported a high level of satisfaction and supported the model, but found software integration challenging. Patients found the system attractive and felt well managed. Specialist consults occurred within a week, and if a second specialist opinion was required, it took another 2 weeks.ConclusionsThe programme demonstrated safe, expedited and efficient follow up with a clinical and web based programme. Support from the general practitioners and patients was encouraging, despite logistical issues. Ongoing evaluation of VC services will continue and feasibility to larger networks and more chronic diseases remains the long term goal.