bluuebunny/crossref_metadata_2025_split huggingface dataset:
Levels of S100B protein drive the reparative process in acute muscle injury and muscular dystrophy
Authors: Riuzzi Francesca , Beccafico Sara , Sagheddu Roberta , Chiappalupi Sara , Giambanco Ileana , Bereshchenko Oxana , Riccardi Carlo , Sorci Guglielmo , Donato Rosario 
Published: September 2017

AbstractRegeneration of injured skeletal muscles relies on a tightly controlled chain of cellular and molecular events. We show that appropriate levels of S100B protein are required for timely muscle regeneration after acute injury. S100B released from damaged myofibers and infiltrating macrophages expands the myoblast population, attracts macrophages and promotes their polarization into M2 (pro-regenerative) phenotype, and modulates collagen deposition, by interacting with RAGE (receptor for advanced glycation end-products) or FGFR1 (fibroblast growth factor receptor 1) depending on the muscle repair phase and local conditions. However, persistence of high S100B levels compromises the regeneration process prolonging myoblast proliferation and macrophage infiltration, delaying M1/M2 macrophage transition, and promoting deposition of fibrotic tissue via RAGE engagement. Interestingly, S100B is released in high abundance from degenerating muscles ofmdxmice, an animal model of Duchenne muscular dystrophy (DMD), and blocking S100B ameliorates histopathology. Thus, levels of S100B differentially affect skeletal muscle repair upon acute injury and in the context of muscular dystrophy, and S100B might be regarded as a potential molecular target in DMD.
Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP)
Authors: Bainbridge Travis W. , Dunshee Diana Ronai , Kljavin Noelyn M. , Skelton Nicholas J. , Sonoda Junichiro , Ernst James A. 
Published: September 2017

AbstractFibroblast Activation Protein (FAP) is a membrane-bound serine protease whose expression is often elevated in activated fibroblasts associated with tissue remodeling in various common diseases such as cancer, arthritis and fibrosis. Like the closely related dipeptidyl peptidase DPPIV, the extracellular domain of FAP can be released into circulation as a functional enzyme, and limited studies suggest that the circulating level of FAP correlates with the degree of tissue fibrosis. Here we describe a novel homogeneous fluorescence intensity assay for circulating FAP activity based on a recently identified natural substrate, FGF21. This assay is unique in that it can effectively distinguish endopeptidase activity of FAP from that of other related enzymes such as prolyl endopeptidase (PREP) and was validated usingFap-deficient mice. Structural modeling was used to elucidate the mechanistic basis for the observed specificity in substrate recognition by FAP, but not by DPPIV or PREP. Finally, the assay was used to detect elevated FAP activity in human patients diagnosed with liver cirrhosis and to determine the effectiveness of a chemical inhibitor for FAP in mice. We propose that the assay presented here could thus be utilized for diagnosis of FAP-related pathologies and for the therapeutic development of FAP inhibitors.
A penalty on photosynthetic growth in fluctuating light
Authors: Graham Percival J. , Nguyen Brian , Burdyny Thomas , Sinton David 
Published: September 2017

AbstractFluctuating light is the norm for photosynthetic organisms, with a wide range of frequencies (0.00001 to 10 Hz) owing to diurnal cycles, cloud cover, canopy shifting and mixing; with broad implications for climate change, agriculture and bioproduct production. Photosynthetic growth in fluctuating light is generally considered to improve with increasing fluctuation frequency. Here we demonstrate that the regulation of photosynthesis imposes a penalty on growth in fluctuating light for frequencies in the range of 0.01 to 0.1 Hz (organisms studied:Synechococcus elongatusandChlamydomonas reinhardtii). We provide a comprehensive sweep of frequencies and duty cycles. In addition, we develop a 2ndorder model that identifies the source of the penalty to be the regulation of the Calvin cycle – present at all frequencies but compensated at high frequencies by slow kinetics of RuBisCO.
A moving story: Whole-body motor training selectively improves the appraisal of action meanings in naturalistic narratives
Authors: Trevisan Piergiorgio , Sedeño Lucas , Birba Agustina , Ibáñez Agustín , García Adolfo M. 
Published: September 2017

AbstractThis study examined whether systematic whole-body stimulation and increased attention to visuospatial motion patterns can enhance the appraisal of action meanings evoked by naturalistic texts. Participants listened to action and neutral (non-action) narratives before and after videogame-based bodily training, and responded to questions on information realized by verbs (denoting abstract and action processes) and circumstances (conveying locative or temporal details, for example). Strategically, we worked with dyslexic children, whose potential comprehension deficits could give room to post-training improvements. Results showed a selective boost in understanding of action information, even when controlling for baseline performance. Also, this effect proved uninfluenced by short-term memory skills, and it was absent when training relied on non-action videogames requiring minimal bodily engagement. Of note, the movements described in the texts did not match those performed by participants, suggesting that well-established effector- and direction-specific language embodiment effects may be accompanied by more coarse-grained sensorimotor resonance, driven by activation of motor and visuospatial sensory systems. In sum, the stimulation of movement-related mechanisms seems to selectively boost the appraisal of actions evoked by naturalistic texts. By demonstrating such links between two real-life activities, our study offers an empirical tie between embodied and situated accounts of cognition.
Reversible control of the magnetization of spinel ferrites based electrodes by lithium-ion migration
Authors: Wei Guodong , Wei Lin , Wang Dong , Chen Yanxue , Tian Yufeng , Yan Shishen , Mei Liangmo , Jiao Jun 
Published: September 2017

AbstractLithium-ion (Li-ion) batteries based on spinel transition-metal oxide electrodes have exhibited excellent electrochemical performance. The reversible intercalation/deintercalation of Li-ions in spinel materials enables not only energy storage but also nondestructive control of the electrodes’ physical properties. This feature will benefit the fabrication of novel Li-ion controlled electronic devices. In this work, reversible control of ferromagnetism was realized by the guided motion of Li-ions in MnFe2O4 and γ-Fe2O3 utilizing miniature lithium-battery devices. The in-situ characterization of magnetization during the Li-ion intercalation/deintercalation process was conducted, and a reversible variation of saturation magnetization over 10% was observed in both these materials. The experimental conditions and material parameters for the control of the ferromagnetism are investigated, and the mechanism related to the magnetic ions’ migration and the exchange coupling evolution during this process was proposed. The different valence states of tetrahedral metal ions were suggested to be responsible for the different performance of these two spinel materials.
Kerogen Swelling and Confinement: Its implication on Fluid Thermodynamic Properties in Shales
Authors: Pathak Manas , Kweon Hyukmin , Deo Milind , Huang Hai 
Published: September 2017

AbstractType I kerogen was isolated from Green River Shale and characterized using SEM, TGA, DSC, and nitrogen adsorption. The swelling behavior of this kerogen with decane was analyzed using traditional test-tube swelling experiment and Dynamic Light Scattering. The TGA and DSC were used to analyze the thermodynamic behavior of decane that was sorbed in the kerogen and show that kerogen suppresses the boiling point of decane due to the effect of confinement. However, the suppression is larger when oil (a multicomponent mixture) was used, possibly due to the combined effect of differential uptake of components by kerogen (kerogen prefers and sorbs polars and aromatics more than saturates, leading to splitting of oil into a sorbed and a free phase) and confinement in nano pores. Test-tube swelling, TGA, and DSC experiments were also performed on pyridine(polar-aromatic)-swelled kerogen. The combined and individual contributions from the two effects (the effect of confinement and differential uptake of hydrocarbon components) on properties of liquid in contact with kerogen, are studied in this work. Molecular Dynamics (MD) simulations revealed the variation in the swelling of type II kerogen in the presence of same amount of different liquids (differential swelling of kerogen).
Microscale Bioreactors for in situ characterization of GI epithelial cell physiology
Authors: Costello Cait M. , Phillipsen Mikkel B. , Hartmanis Leonard M. , Kwasnica Marek A. , Chen Victor , Hackam David , Chang Matthew W. , Bentley William E. , March John C. 
Published: September 2017

AbstractThe development of in vitro artificial small intestines that realistically mimic in vivo systems will enable vast improvement of our understanding of the human gut and its impact on human health. Synthetic in vitro models can control specific parameters, including (but not limited to) cell types, fluid flow, nutrient profiles and gaseous exchange. They are also “open” systems, enabling access to chemical and physiological information. In this work, we demonstrate the importance of gut surface topography and fluid flow dynamics which are shown to impact epithelial cell growth, proliferation and intestinal cell function. We have constructed a small intestinal bioreactor using 3-D printing and polymeric scaffolds that mimic the 3-D topography of the intestine and its fluid flow. Our results indicate that TEER measurements, which are typically high in static 2-D Transwell apparatuses, is lower in the presence of liquid sheer and 3-D topography compared to a flat scaffold and static conditions. There was also increased cell proliferation and discovered localized regions of elevated apoptosis, specifically at the tips of the villi, where there is highest sheer. Similarly, glucose was actively transported (as opposed to passive) and at higher rates under flow.
Recent Advances in Transition-Metal-Free Aryl C–B Bond Formation
Authors: Meng Ge , Li Pengfei , Chen Kai , Wang Linghua 
Published: September 2017

Arylboronic acids and their derivatives are widely used in organic synthesis. Conventional methods for their preparation require either reactive organometallic reagents or transition-metal-mediated processes. In recent years, transition-metal-free reactions for aryl C–B bond formation that obviate preformed organometallic reagents have gained interest and have developed rapidly. These new reactions have shown significant advantages for the preparation of functionalized molecules. In this review, an overview of the recent advances in transition-metal-free aromatic borylation reactions is provided.1	Introduction2	Transition-Metal-Free Transformations of CAr–N Bonds to CAr–B Bonds3	Transition-Metal-Free Transformations of CAr–X Bonds to CAr–B Bonds4	Transition-Metal-Free Transformations of CAr–H Bonds to CAr–B Bonds5	Conclusion
‘I Would Like to be a Healthy Egoist’: A Case of Ceratostigma willmottiana
Authors: Collins Deborah 
Published: September 2017

AbstractThis is the case of a woman suffering from depression and burnout, dating back to a childhood where she felt that she had to put all her own desires and ambitions aside due to the family situation: a drunken father and a mother who cared for him but had little time for her children. It was only with the help of the Plant theory that a suitable remedy was found.
Resolving the Rift between High Culture and Instinct: Bergenia ciliata
Authors: Begin Marty 
Published: September 2017

AbstractThe case of a 34-year-old mother and naturopath progresses in a deeper way after applying Jan Scholten's plant system to arrive at Bergenia ciliata. The patient is able to integrate and solve her conflict between her intuitive and rational sides, which for her parallels her struggle to be herself in high mainstream society.
Migraine and the Scope of Homeopathy
Authors: Wandile Pranali 
Published: September 2017

AbstractMigraine is usually a genetic disorder. In the United States, every 10 seconds someone with a migraine goes to the emergency room. Approximately 1.2 million annual visits to the emergency room occur due to acute migraine attacks. About 90% of migraine patients have a family history of this illness. More than 90% of sufferers are unable to work or function normally during their migraine episode, affecting their quality of life and medical expenditure. While the majority of patients experience attacks once or twice a month, more than four million people suffer due to a chronic migraine with at least 15 migraine days per month. Migraine is often undiagnosed and undertreated and remains a poorly understood disease. In spite of the high prevalence of migraine and its effects on patients, research into migraine is still underfunded. In this article, the author reviewed facts about migraine, the best possible suggested treatments and the scope of homeopathy for its treatment. More research and clinical trials with improved trial designs are warranted. Publications of large numbers of homeopathic case studies worldwide, long-term observational studies of treated migraine patients having no further migraine recurrences are needed to see the role of homeopathy for the complete cure.
Síndrome del túnel radial. Epicondilitis resistente
Authors: Pérez C. , Ferrero M. A. 
Published: September 2017

Desde 1996 a 2003, 25 pacientes (26 extremidades) fueron intervenidos de síndrome del túnel radial. Todos los procedimientos fueron realizados por el mismo cirujano y en el mismo hospital realizando un abordaje postero-externo del túnel radial.Se realizó un seguimiento de todos los pacientes en el tiempo después de la cirugía de 4 meses a 6 años y 4 meses (tiempo medio de 22 meses).Los resultados fueron evaluados según los criterios de Roles y Mausdley; 12 pacientes tuvieron resultados excelentes (45,15%), 9 pacientes buenos (34,61%) y 5 pacientes regulares (19,23%).11 pacientes fueron tratados previamente de epicondilitis lateral (entesitis).La mayoría de los pacientes están satisfechos con la cirugía refiriendo un alivio de la sintomatología y una mejora de la funcionalidad tras la cirugía.
Artroplastia estabilizadora y de interposición para artrodesis previa de la articulación trapecio-metacarpiana del pulgar
Authors: De Santolo R. , Ortiz Magalli , Briceño Leonardo , Cevedo R T. O. 
Published: September 2017

La articulación carpometacarpiana o trapecio-metacarpiana del pulgar es la más importante para las diferentes pinzas. Su artrodesis fue realizada en el pasado frecuentemente, pero ella deja como residuo una severa incapacidad funcional. Con los avances actuales de los modernos procedimientos quirúrgicos, la artrodesis de la trapecio-metacarpiana estaría inclinada sólo en casos excepcionales.Presentamos el resultado de 8 pacientes con artrodesis de la trapecio-metacarpiana realizadas en otras instituciones, nosotros las convertimos en artroplastias estabilizadoras y de interposición con excelentes o buenos resultados, 5 de ellos fueron artrodesados por secuelas de fracturas y 3 por Rizoartrosis. La edad de los pacientes osciló entre 37 y 59 años con promedio de 43, ninguno de los pacientes tenía un trabajo exigente o manual.El programa de Rehabilitación es muy importante para obtener excelentes o buenos resultados, en 3 obtuvimos excelentes resultados, 2 buenos y 1 regular, según la escala de EATON, sólo con 3 complicaciones.Son nuestras conclusiones que la conversión de una artrodesis en artroplastia en la base del pulgar es muy satisfactoria, el paciente lo agradece mucho porque le disminuye la incapacidad, le elimina el dolor y deja una trapecio-metacarpiana muy estable por la reconstrucción de su ligamento más importante, con unos de los tendones del Abductor largo del pulgar (digástrico), interponiendo alrededor de éste la cápsula articular.
Remodelación ósea tras el tratamiento quirúrgico del quiste óseo aneurismático de localización metacarpiana en el niño
Authors: Soldado-Carrera F. , de la Fuente J.P. , Arce A. , Canyadell M. 
Published: September 2017

El quiste óseo aneurismático localizado en la mano es poco frecuente.No se ha descrito su incidencia real en la infancia, ni la influencia que sobre la evolución del tumor puede tener la presencia de cartílagos de crecimiento abiertos.La remodelación ósea permite que el hueso cambie de forma (“reshaping”) o sea sustituido después de una lesión.Presentamos el caso de un QOA localizado en el cuarto metacarpiano de la mano derecha en una niña de 5 años de edad. Fue intervenida y a los nueve años de seguimiento se objetivó una remodelación tubular completa del metacarpiano. La eliminación del factor lesivo y la presencia de cartílagos de crecimiento abiertos ha permitido la retubulización.
„Nur“ palliativ? Therapie mit Kortison und Sulfur bei einer atopisch-psorischen Patientin
Authors: Gnaiger-Rathmanner Jutta 
Published: September 2017

ZusammenfassungEine Patientin mit schwerer Atopie unterzieht sich aus eigener Initiative teils gleichzeitig, teils phasenverschoben der Kortisontherapie sowie der Homöopathie, vor allem mit Sulfur. Es lassen sich dabei alle bekannten Phänomene einer chronischen Erkrankung unter den Aspekten von Psora, Suppression, Organwechsel, Palliativbehandlung und regulativen Therapieerfolgen auffinden. Es stellen sich daran viele Fragen zur modernen Therapiesituation in unseren Praxen.
Urinary Incontinence in Physically Active Young Women: Prevalence and Related Factors
Authors: Alves Jessica , Luz Soraia , Brandão Sofia , Da Luz Clarissa , Jorge Renato , Da Roza Thuane 
Published: September 2017

AbstractThis cross-sectional survey aims to (1) verify the prevalence of urinary incontinence and its impact on the quality of life among nulliparous fit women, and to (2) analyze whether urinary incontinence is influenced by the intensity of the sport (high- vs. low-impact) or by the volume of physical activity (minutes per week) performed. Two hundred forty-five nulliparous women (18–40 years) completed the International Consultation on Incontinence Questionnaire-Short Form, the Kings Health Questionnaire and a questionnaire regarding demographic and training variables. Overall 22.9% of the participants self-reported urinary incontinence, and among them, 60.7% had stress urinary incontinence. Incontinent women demonstrated worse quality of life than continent females (p=0.000). Women practicing high-impact sports presented higher frequency in loss of urine than those practicing low-impact sports (p=0.004). Regardless the intensity of the sport, the volume of exercise showed positive association with the frequency of loss of urine (p=0.005, r=0.475). In conclusion, almost one fourth of the women enrolled in this study reported symptoms of urinary incontinence and worse quality of life than those who were continent. Women who practice high-impact sports or who have higher volume of training should be aware of the symptoms associated with pelvic floor dysfunction, since they seem to predispose to urine leakage.
Die Palliation bei Schmerzen und postoperativen Folgezuständen
Authors: Friedrich Uwe 
Published: September 2017

ZusammenfassungDie homöopathische Schmerzbehandlung gelingt durch das Simile im Rahmen eines kurativen Ansatzes und mit homöopathischen Mitteln, die allein durch die Schmerzsymptomatik bestimmt werden und damit meist „nur“ palliativ wirken. Mittelfindung, Symptome und Dosierung unter besonderer Berücksichtigung von Krebsschmerzen werden dargestellt.Außerdem wird an 2 Fällen gezeigt, wie palliative homöopathische Mittel iatrogene anatomische Defekte mit ihren Folgebeschwerden günstig beeinflussen können.
Die Charakteristika von Allium cepa
Authors: Thoma Christian 
Published: September 2017

ZusammenfassungFür den Vergleich der charakteristischen Patientensymptome mit den charakteristischen Arzneisymptomen ist eine verlässliche primäre Materia medica erforderlich. Anhand der neu revidierten Allium-cepa-Monografie werden die Charakteristika der Arznei dargestellt. Weiters wird diskutiert, wie Charakteristika einer Arznei zu ermitteln sind.
Diagnostic Accuracy of an MRI Protocol of the Knee Accelerated Through Parallel Imaging in Correlation to Arthroscopy
Authors: Schnaiter Johannes , Roemer Frank , McKenna-Kuettner Axel , Patzak Hans-Joachim , May Matthias , Janka Rolf , Uder Michael , Wuest Wolfgang 
Published: September 2017

Purpose Parallel imaging allows for a considerable shortening of examination times. Limited data is available about the diagnostic accuracy of an accelerated knee MRI protocol based on parallel imaging evaluating all knee joint compartments in a large patient population compared to arthroscopy.
Materials and Methods 162 consecutive patients with a knee MRI (1.5 T, Siemens Aera) and arthroscopy were included. The total MRI scan time was less than 9 minutes. Meniscus and cartilage injuries, cruciate ligament lesions, loose joint bodies and medial patellar plicae were evaluated. Sensitivity (SE), specificity (SP), positive predictive value (PPV), and negative predictive value (NPV), as well as diagnostic accuracy were determined.
Results For the medial meniscus, the values were: SE 97 %, SP 88 %, PPV 94 %, and NPV 94 %. For the lateral meniscus the values were: SE 77 %, SP 99 %, PPV 98 %, and NPV 89 %. For cartilage injuries the values were: SE 72 %, SP 80 %, PPV 86 %, and NPV 61 %. For the anterior cruciate ligament the values were: SE 90 %, SP 94 %, PPV 77 %, and NPV 98 %, while all values were 100 % for the posterior cruciate ligament. For loose bodies the values were: SE 48 %, SP 96 %, PPV 62 %, and NPV 93 %, and for the medial patellar plicae the values were: SE 57 %, SP 88 %, PPV 18 %, and NPV 98 %.
Conclusion A knee MRI examination with parallel imaging and a scan time of less than 9 minutes delivers reliable results with high diagnostic accuracy.
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Addressing women in the Greek parliament
Authors: Georgalidou Marianthi 
Published: September 2017

AbstractIn accordance with numerous studies highlighting aspects of political and parliamentary discourse that concern the rhetoric of political combat, verbal attacks and offensive language choices are shown to be rather common in the context of a highly adversarial parliamentary system such as the Greek. In the present study, however, the analysis of excerpts of parliamentary discourse addressed to women reveals not just aspects of the organization of rival political encounters but, as far as female MPs are concerned, aggressive and derogatory forms of speech that directly attack the gender of the addressees. Drawing on data from video-recordings, the official proceedings of parliamentary sittings, and the media (2012–2015), the present study investigates aggressive/sexist discourse within this context. The theoretical issues addressed concern the impoliteness end of the politeness/politic speech/impoliteness continuum in the light of extreme cases of conflict in political/parliamentary discourse.