bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Foeniculum vulgare (fennel) on vaginal atrophy in postmenopausal women: A double-blind, randomized, placebo-controlled trial
Authors: Ghazanfarpour Masumeh , Shokrollahi Paymaneh , Khadivzadeh Talat , Baharian Sharghi Nosrat , Mirzaii Najmabadi Khadijeh , Babakhanian Masoudeh , Jafarian Amir Hossine 
Published: October 2017

Objectives This study was conducted to evaluate the effects of orally administered fennel on vaginal atrophy. Materials and methods In this double-blind, randomized, placebo-controlled trial, 60 postmenopausal women living in Mashhad, Iran, were randomly divided into an oral fennel group (n = 30) and a placebo group (n = 30). The Maturation Vaginal Index and maturation values were measured once at baseline and again upon a three-month follow-up. Results The paired t-test showed statistically significant changes in the Maturation Vaginal Index (i.e. a decline in the parabasal cells and an increase in the intermediate and superficial cells) and maturation values in both the fennel and placebo groups at the end of the trial compared to at baseline. Nonetheless, no significant differences were observed in the percentages of the parabasal (P = 0.191), intermediate (P = 0.219) and superficial (P = 0.82) cells, which was also the case for the maturation values (P = 0.64). Conclusion Fennel had no significant positive effects on vaginal atrophy in postmenopausal women. Nonetheless, more studies are recommended to be conducted using higher doses of fennel and larger sample sizes so as to verify the results of this study.
Randomized controlled trial of an e-learning designed behavioral intervention for increasing physical activity behavior in multiple sclerosis
Authors: Motl Robert W , Hubbard Elizabeth A , Bollaert Rachel E , Adamson Brynn C , Kinnett-Hopkins Dominique , Balto Julia M , Sommer Sarah K , Pilutti Lara A , McAuley Edward 
Published: October 2017

Background Internet-delivered, behavioral interventions represent a cost-effective, broadly disseminable approach for teaching persons with multiple sclerosis (MS) the theory-based skills, techniques, and strategies for changing physical activity. Objectives This pilot, randomized controlled trial examined the efficacy of a newly developed Internet website based on e-learning approaches that delivered a theory-based behavior intervention for increasing physical activity and improving symptoms, walking impairment, and neurological disability. Methods Participants with MS ( N = 47) were randomly assigned into behavioral intervention ( n = 23) or waitlist control ( n = 24) conditions delivered over a six-month period. Outcomes were administered before and after the six-month period using blinded assessors, and data were analyzed using analysis of covariance in SPSS. Results There was a significant, positive intervention effect on self-reported physical activity ( P = 0.05, [Formula: see text] = 0.10), and non-significant improvement in objectively measured physical activity ( P = 0.24, [Formula: see text] = 0.04). There were significant, positive effects of the intervention on overall ( P = 0.018, [Formula: see text] = 0.13) and physical impact of fatigue ( P = 0.003, [Formula: see text] = 0.20), self-reported walking impairment ( P = 0.047, [Formula: see text] = 0.10), and disability status ( P = 0.033, [Formula: see text] = 0.11). There were non-significant improvements in fatigue severity ( P = 0.10, [Formula: see text] = 0.06), depression ( P = 0.10, [Formula: see text] = 0.07) and anxiety ( P = 0.06, [Formula: see text] = 0.09) symptoms, and self-reported disability ( P = 0.10, [Formula: see text] = 0.07). Conclusions We provide evidence for the efficacy of an Internet-based behavioral intervention with content delivered through interactive video courses grounded in e-learning principles for increasing physical activity and possibly improving secondary outcomes of fatigue, depression, anxiety, and walking impairment/disability in persons with MS.
Having a bad attitude? The relationship between attitudes and sickness absence
Authors: Hauge Karen Evelyn , Ulvestad Marte Eline 
Published: October 2017

AbstractIs sickness absence related to attitudes? Several studies point to attitudes as an important factor for sickness absence. We study the relation between sickness absence and attitudes towards possible reasons for sick leave, towards cheating and towards work, by linking a survey among Norwegian healthcare workers, aimed at identifying attitudes, to detailed data on sickness absence from the employers. We find that there is an association between sickness absence and certain attitudes but mainly for self-certified sick leave. Employees with more lenient attitudes towards sick leave have more self-certified sick leave, but not more GP-certified sick leave. Furthermore, we find no evidence of attitudes being able to explain the persistently observed differences is absenteeism between different demographic groups.
Long-Term Outcomes in Patients With BRAF V600–Mutant Metastatic Melanoma Who Received Dabrafenib Combined With Trametinib
Authors: Long Georgina V. , Eroglu Zeynep , Infante Jeffrey , Patel Sapna , Daud Adil , Johnson Douglas B. , Gonzalez Rene , Kefford Richard , Hamid Omid , Schuchter Lynn , Cebon Jonathan , Sharfman William , McWilliams Robert , Sznol Mario , Redhu Suman , Gasal Eduard , Mookerjee Bijoyesh , Weber Jeffrey , Flaherty Keith T. 
Published: October 2017

Purpose To report 5-year landmark analysis efficacy and safety outcomes in patients with BRAF V600–mutant metastatic melanoma (MM) who received BRAF inhibitor dabrafenib (D) and MEK inhibitor trametinib (T) combination therapy versus D monotherapy in the randomized phase II BRF113220 study part C. Patients and Methods BRAF inhibitor–naive patients with BRAF V600–mutant MM were randomly assigned 1:1:1 to receive D 150 mg twice a day, D 150 mg twice a day plus T 1 mg once daily, or D 150 mg twice a day plus T 2 mg once daily (D + T 150/2). Patients who received D monotherapy could cross over to D + T 150/2 postprogression. Efficacy and safety were analyzed 4 and 5 years after initiation in patients with ≥ 5 years of follow-up. Results As of October 13, 2016, 18 patients who received D + T 150/2 remained in the study (13 [24%] of 54 enrolled at this dose plus five [11%] of 45 initially administered D who crossed over to D + T). With D + T 150/2, overall survival (OS; 4 years, 30%; 5 years, 28%) and progression-free survival (4 and 5 years, both 13%) appeared to stabilize with extended follow-up. Increased OS was observed in patients who received D + T with baseline normal lactate dehydrogenase (5 years, 45%) and normal lactate dehydrogenase with fewer than three organ sites with metastasis (5 years, 51%). With extended follow-up, one additional patient who received D + T 150/2 improved from a partial to a complete response. No new safety signals were observed. Conclusion This 5-year analysis represents the longest follow-up to date with BRAF + MEK inhibitor combination therapy in BRAF V600–mutant MM. Consistent with trends observed in landmark analyses with shorter follow-up, this therapy elicits durable plateaus of long-term OS and progression-free survival that last ≥ 5 years in some patients with MM.
MMP-14 overexpression correlates with the neurodegenerative process in familial amyloidotic polyneuropathy
Authors: Martins Diana , Moreira João , Gonçalves Nádia Pereira , Saraiva Maria João 
Published: October 2017

ABSTRACT
Levels of matrix metalloproteases (MMPs) can be differentially regulated in response to injury or neurological diseases. For instance, it is known that selective and short-term inhibition of MMP-14, a membrane-type 1 MMP, accelerates axon regeneration. Because axon growth and regeneration is impaired in familial amyloidotic polyneuropathy (FAP), a neurodegenerative disorder characterized by misfolding and deposition of mutant transthyretin (TTR) in the peripheral nervous system (PNS), we presently investigated the expression levels and the potential role for MMP-14 in this condition. By using cell culture studies, a mouse model of disease and human clinical samples, we observed that MMP-14: (i) is overexpressed in FAP nerves, correlating with TTR deposition; (ii) is upregulated in sciatic nerves from a preclinical transgenic mouse model, increasing with TTR deposition; (iii) levels in the PNS and plasma are rescued upon treatment of mice with anakinra or TTR siRNA, drugs acting over the IL-1 signaling pathway or TTR liver synthesis, respectively; (iv) increases in Schwann cells upon incubation with amyloid-like aggregates; and, finally, (v) is increased in plasma of FAP patients, correlating with disease progression. These results highlight the relevance of MMP-14 in the pathophysiology of FAP, suggesting not only a potential role for this molecule as a novel biomarker for therapy follow up, but also as a new potential therapeutic target.
Central and peripheral circadian clocks and their role in Alzheimer's disease
Authors: Chauhan Ruchi , Chen Ko-Fan , Kent Brianne A. , Crowther Damian C. 
Published: October 2017

ABSTRACT
Molecular and cellular oscillations constitute an internal clock that tracks the time of day and permits organisms to optimize their behaviour and metabolism to suit the daily demands they face. The workings of this internal clock become impaired with age. In this review, we discuss whether such age-related impairments in the circadian clock interact with age-related neurodegenerative disorders, such as Alzheimer's disease. Findings from mouse and fly models of Alzheimer's disease have accelerated our understanding of the interaction between neurodegeneration and circadian biology. These models show that neurodegeneration likely impairs circadian rhythms either by damaging the central clock or by blocking its communication with other brain areas and with peripheral tissues. The consequent sleep and metabolic deficits could enhance the susceptibility of the brain to further degenerative processes. Thus, circadian dysfunction might be both a cause and an effect of neurodegeneration. We also discuss the primary role of light in the entrainment of the central clock and describe important, alternative time signals, such as food, that play a role in entraining central and peripheral circadian clocks. Finally, we propose how these recent insights could inform efforts to develop novel therapeutic approaches to re-entrain arrhythmic individuals with neurodegenerative disease.
A comparison of spatial heterogeneity with local cluster detection methods for chronic respiratory diseases in Thailand
Authors: Laohasiriwong Wongsa , Puttanapong Nattapong , Luenam Amornrat 
Published: October 2017

Background: The Centers for Disease Control and Prevention reported that deaths from chronic respiratory diseases (CRDs) in Thailand increased by almost 13% in 2010, along with an increased burden related to the disease. Evaluating the geographical heterogeneity of CRDs is important for surveillance. Previous studies have indicated that socioeconomic status has an effect on disease, and that this can be measured with variables such as night-time lights (NTLs) and industrial density (ID). However, there is no understanding of how NTLs and ID correlate with CRDs. We compared spatial heterogeneity obtained by using local cluster detection methods for CRDs and by correlating NTLs and ID with CRDs. Methods: We applied the spatial scan statistic in SaTScan, as well as local indices of spatial association (LISA), Getis and Ord’s local Gi*(d) statistic, and Pearson correlation. In our analysis, data were collected on gender, age, household income, education, family size, occupation, region, residential area, housing construction materials, cooking fuels, smoking status and previously diagnosed CRDs by a physician from the National Socioeconomic Survey, which is a cross-sectional study conducted by the National Statistical Office of Thailand in 2010. Results: According to our findings, the spatial scan statistic, LISA, and the local Gi*(d) statistic revealed similar results for areas with the highest clustering of CRDs. However, the hotspots for the spatial scan statistic covered a wider area than LISA and the local Gi*(d) statistic. In addition, there were persistent hotspots in Bangkok and the perimeter provinces. NTLs and ID have a positive correlation with CRDs. Conclusions: This study demonstrates that all the statistical methods used could detect spatial heterogeneity of CRDs. NTLs and ID can serve as new parameters for determining disease hotspots by representing the population and industrial boom that typically contributes to epidemics.
PRINSIP-PRINSIP HUKUM/HAK-HAK KELUARGA DALAM FIKIH JA’FARI & SISTEM SYAR’I REPUBULIK ISLAM IRAN
Authors: Nejad Seyed Ahmad Habib 
Published: October 2017

Prinsip sentralitas keluarga dalam sistem hukum Iran dapat banyak membantu keseimbangan kepentingan dalam sistem hukumnya. Hal-hal yang berhubungan dengan ahwal syakhshiyyah, terutama pernikahan, dalam seluruh agama, memiliki relasi yang kuat dengan kayakinan keagamaan. Dari satu sisi, ketidakpedulian terhadap perubahan-perubahan sosial akan memunculkan undang-undang yang mati dan kaku dalam hubungan sosial. Dan dari sisi lain, mengabaikan nilai-nilai keagamaan dan terutama pada perilaku yang memiliki sensitifitas terhadap madzhab akan melahirkan dualitas dalam sistem-sistem yang mendominasi perilaku sosial. Ide sentralitas keluarga, dengan memanfaatkan hukum-hukum fikih dan memperhatikan al-ghayah asy-syar’iyyah dari hukum pernikahan dalam fikih Ja’fari melalui pembaharuannya, relatif dapat memberikan dominasi pandangan terhadap hak-hak keluarga di Iran dalam menghadapi perubahan-perubahan sosial dan mengarahkan kepada sistem tunggal dalam sistem keluarga di tengah masyarakat Iran sebagai negara religius. Prinsip-prinsip hasil istinbath dari referensi-referensi ijtihad menurut maktab fikih Ja’fari dalam bidang hukum/hak-hak keluarga dan dimasukkan dalam UUD Republik Islam Iran, melahirkan dominasi sistem hukum khusus terhadap keluarga. Pasal 10 UUD Republik Islam Iran menjadikan keluarga sebagai yang terpenting dan pemersatu masyarakat. Maka seluruh undang-undang, aturan dan perencanaan yang berhubungan dengan itu bertujuan memudahkan pembentukan keluarga dan menjaga kesucian dan kelanggengan hubungan kekeluargaan.
VISIBILITAS HUBUNGAN KEMITRAAN PADA POLA INTERAKSI SUAMI-ISTRI DALAM PANDANGAN AL-SYAFI’I
Authors: Qadafy Mu’ammar Zayn 
Published: October 2017

The Perspective of al-Syafi’I on Partnership in Marriage In husband and wife relationships, contemporary couples prefer a partnership pattern rather than one of leadership. Although the latter is not necessary better than the former, it is obviously more accommodative of modern ideas of justice, egalitarianism and gender equality. This article aims to explore the connections between household partnership patterns, as fundamental to contemporary Muslim’s, and the traditional Islamic jurisprudence (fikih) most dominant among the diverse adherents of Islam. More specifically, this research describes al-Syafi`í thought. To explore the partnership patterns of married couples, it elaborates on three points: (1) the meaning of qawwamuna, (2) the concept of bride price and household expenses, and (3) interactions between husband and wife. The primary resource use in this research is al-Umm. This article concludes that Syafi’i jurisprudence implicitly accommodates the idea of partnership between marriage partners, as evident in (1) the acknowledgement of a woman’s right to choose her husband; (2) the bride price, which has both legal, formal and moral implications; (3) the co-understanding of the marriage partners in matters of household expenses and the emphasizing of discussion in solving financial problems; and (4) the use of good reason in dealing with household and personal conflicts.
KEDUDUKAN PEREMPUAN DALAM ISLAM MENURUT MADZHAB JA’FARI
Authors: Sobhaninia Mohammad Taqi 
Published: October 2017

Islam telah menganugerahkan identitas yang tinggi dan bermartabat kepada perempuan dengan hukum-hukum taklif dan akhlak yang mulia, mengeluarkannya dari perbudakan, kehancuran dan hilangnya jati diri, dan memandangnya dengan kemuliaan dan penghormatan di tengah masyarakat ketika tidak seorangpun ingin melahirkan seorang anak perempuan. Artikel ini membahas perempuan dalam Islam, terutama menurut perspektif madzhab Ja’fari yang akan menjawab pertanyaan-pertanyaan dan problema-problema yang muncul terkait perempuan dan kedudukannya dalam Islam dengan bersandar kepada ayat-ayat al-Quran dan riwayatriwayat. Dengan demikian, Islam telah memberikan kehidupan kepada perempuan. Islam telah merubah tradisi-tradisi terdahulu dan menyebutkan perempuan sebagai penyebab turunnya rahmat Allah swt. Dari satu sisi, membesarkan dan mendidik perempuan dijadikan sebagai sumber kebahagiaan kedua orang tua dan dari sisi lain, Islam memberikan penghormatan kepada seorang ibu dengan ungkapan yang terkenal: “Surga di bawah telapak kaki ibu.”
URGENSI PENCATATAN SIPIL DALAM PEMENUHAN HAK ANAK TELAAH MENURUT IMAM SYAFI’I DAN HAM
Authors: Zamroni Mohammad 
Published: October 2017

The Urgency of Civil Registration in the Fulfilment of the Rights of the Child From birth Indonesian children have the basic right to be protected by the State and according to religion. One of the basic rights of the child is the right to obtain a birth certificate through the civil registration system. In this context, all children are seen to have the same basic human rights, and the same is true according to Islam. For example, there is no differentiation in relation to whether a child is born within marriage or illegitimately. From a human rights perspective, all children have an equal rights. Similarly, in Islamic jurisprudence according to the Imam Shafi’i School there are no limits to the care of a child. Civil registration of birth ensures human rights in relation to social status and individual benefits. The civil registration system gives individuals a unique identity, records the relationship with parents, and provides the foundation for citizenship. Birth certificates provide documentation of the birth of the child and usually one or both parents, which was fundamental to the determination of nationality, depending on the laws of each country. Civil registration is also important in recording death, marriage, divorce and so forth.
TAFSIR AYAT-AYAT GENDER ALA AMINA WADUD PERSPEKTIF HERMENEUTIKA GADAMER
Authors: Irsyadunnas Irsyadunnas 
Published: October 2017

In the interpretation of the verses of the Qur’an, gender has undergone considerable and dynamic developments. The classical commentators tend to interpret verses textually – normatively, while feminists tend to interpret the verses contextually – sociologically. Along with the developments in the methods or approaches to the contemporary interpretation of the Qur’an, one of the methods or approaches used by feminists is hermeneutics. Through this method or approach, Amina Wadud tries to interpret verses related to the creation of women, women’s leadership, and the problems of polygamy. The result is that the origin of human beings, both males and females, came from a single nafs which is part of the system pairs (nafs itself and its zawj). The leadership clause should be understood in the context of society as a whole through the concept of “functionalist”. On polygamy, there is no direct evidence from the Koran about the permissibility of polygamous marriage, especially in regard to the three validations often cited by proponents, namely financial reasons, reasons of infertility, and the reason the fulfillment of lust or sexual needs.
KEBIJAKSANAAN SYARI’AT ISLAM DALAM BERBUSANA ISLAMI SEBAGAI PEMENUHAN HAK-HAK ANAK PEREMPUAN
Authors: Akbar Eliyyil 
Published: October 2017

Dressing in unwelcome contemporary fashion to mistakenly conceal one’s identity in the name of beauty is one of the causal factors of moral degradation threatening our young generation. To establish their identity and charming personality, many young girls perform malfunction of what they should politely and proportionally wear for the sake of the latest mode and art although they have to break religious laws and teachings. To deal with this phenomenon, regions governed under Islamic law establish suitable fashion criteria and administer mild punishment to whoever violates the policy. Some opponents of the rule have voice protest against it, claiming that it violates women’s right to express their style through fashion. It is widely known that there are some ill-conceived policies stirring up violence against the human rights. However, some policies formulated by Islamic legal administers in Takengon, Central Aceh, have granted women the right to wear the fashion of their choice. Here, the author wants to impart the wisdom of Islamic law in setting down the rule on fashion and in giving young women their rights. The wisdom can act as guidance for lawmakers against the formulation of divisive policies violating human rights. The rule on Islamic fashion in this discussion is based on the Syafi’i teaching that women must cover up their entire body except for the face and the palms of the hands. The wisdom of the Islamic rule is that it reminds and urges young girls to confide in their parents to ensure that their existence as women is protected.
Zbrodnia inkorporowana. O konwencji „paranoicznego gotyku” w Zbrodni z premedytacją Witolda Gombrowicza
Authors: Warkocki Błażej 
Published: October 2017

The article presents the analysis and interpretation (in the form of a close reading) of Witold Gombrowicz’s short story The Premeditated Crime from his debut collection Memoirs from a Time of Immaturity , 1933 (later published under the title Bakakaj or Bacacay in the English translation). The main theoretical framework is the concept of „paranoid Gothic” by Eve Kosofsky Sedgwick, which is based on the reinterpretation of Sigmund Freud’s classic essay Psychoanalytical comments on autobiographically described paranoia . From that perspective Gombrowicz’s narrative is interpreted as a paranoid homosexual narrative, and paranoia itself as a form of love.
O sztuce „nieczystej”, różnie rozumianych obrazach i konkurencyjnych modelach ich interpretacji
Authors: Stankowska Agata 
Published: October 2017

The paper is devoted to the chosen aspects of varied models of defining the image and research practices created by the contemporary art studies – Visual Culture Studies, anthropologically oriented Bildwissenschaft and the French pictorial semiology. What they all have in common is interdisciplinarity that constitutes a response to the „impurity” of art, trespassing its own borders, being autocritical and exposing not only the artistic, but also political, religious, existential and biological status of the image.